PMC:3312845 / 918-1530 JSONTXT

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SE, most activated microglia showed strong TNF-α immunoreactivity. In addition, TNF p75 receptor expression was detected in endothelial cells as well as astrocytes. In addition, only p65-Thr435 phosphorylation was increased in endothelial cells accompanied by SMI-71 expression (an endothelial barrier antigen). Neutralization of TNF-α by soluble TNF p55 receptor (sTNFp55R) infusion attenuated SE-induced vasogenic edema and neuronal damages via inhibition of p65-Thr435 phosphorylation in endothelial cells. Furthermore, sTNFp55R infusion reduced SE-induced neutrophil infiltration in the PC."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T151","span":{"begin":61,"end":66},"obj":"Protein"},{"id":"T152","span":{"begin":98,"end":114},"obj":"Protein"},{"id":"T153","span":{"begin":201,"end":204},"obj":"Protein"},{"id":"T154","span":{"begin":348,"end":353},"obj":"Protein"},{"id":"T155","span":{"begin":365,"end":381},"obj":"Protein"},{"id":"T156","span":{"begin":384,"end":391},"obj":"Protein"},{"id":"T157","span":{"begin":479,"end":482},"obj":"Protein"},{"id":"T158","span":{"begin":542,"end":549},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Results\nFollowing SE, most activated microglia showed strong TNF-α immunoreactivity. In addition, TNF p75 receptor expression was detected in endothelial cells as well as astrocytes. In addition, only p65-Thr435 phosphorylation was increased in endothelial cells accompanied by SMI-71 expression (an endothelial barrier antigen). Neutralization of TNF-α by soluble TNF p55 receptor (sTNFp55R) infusion attenuated SE-induced vasogenic edema and neuronal damages via inhibition of p65-Thr435 phosphorylation in endothelial cells. Furthermore, sTNFp55R infusion reduced SE-induced neutrophil infiltration in the PC."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T479","span":{"begin":369,"end":372},"obj":"http://www.uniprot.org/uniprot/P01589"},{"id":"T476","span":{"begin":348,"end":353},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T459","span":{"begin":201,"end":204},"obj":"http://www.uniprot.org/uniprot/Q04206"},{"id":"T460","span":{"begin":479,"end":482},"obj":"http://www.uniprot.org/uniprot/Q04206"},{"id":"T463","span":{"begin":201,"end":204},"obj":"http://www.uniprot.org/uniprot/P21579"},{"id":"T464","span":{"begin":479,"end":482},"obj":"http://www.uniprot.org/uniprot/P21579"},{"id":"T469","span":{"begin":61,"end":64},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T470","span":{"begin":98,"end":101},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T471","span":{"begin":348,"end":351},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T472","span":{"begin":365,"end":368},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T475","span":{"begin":61,"end":66},"obj":"http://www.uniprot.org/uniprot/P01375"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Results\nFollowing SE, most activated microglia showed strong TNF-α immunoreactivity. In addition, TNF p75 receptor expression was detected in endothelial cells as well as astrocytes. In addition, only p65-Thr435 phosphorylation was increased in endothelial cells accompanied by SMI-71 expression (an endothelial barrier antigen). Neutralization of TNF-α by soluble TNF p55 receptor (sTNFp55R) infusion attenuated SE-induced vasogenic edema and neuronal damages via inhibition of p65-Thr435 phosphorylation in endothelial cells. Furthermore, sTNFp55R infusion reduced SE-induced neutrophil infiltration in the PC."}

{"project":"GO-BP","denotations":[{"id":"T171","span":{"begin":490,"end":505},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T170","span":{"begin":212,"end":227},"obj":"http://purl.obolibrary.org/obo/GO_0016310"}],"text":"Results\nFollowing SE, most activated microglia showed strong TNF-α immunoreactivity. In addition, TNF p75 receptor expression was detected in endothelial cells as well as astrocytes. In addition, only p65-Thr435 phosphorylation was increased in endothelial cells accompanied by SMI-71 expression (an endothelial barrier antigen). Neutralization of TNF-α by soluble TNF p55 receptor (sTNFp55R) infusion attenuated SE-induced vasogenic edema and neuronal damages via inhibition of p65-Thr435 phosphorylation in endothelial cells. Furthermore, sTNFp55R infusion reduced SE-induced neutrophil infiltration in the PC."}

{"project":"GO-CC","denotations":[{"id":"T181","span":{"begin":154,"end":159},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T182","span":{"begin":257,"end":262},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T183","span":{"begin":521,"end":526},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Results\nFollowing SE, most activated microglia showed strong TNF-α immunoreactivity. In addition, TNF p75 receptor expression was detected in endothelial cells as well as astrocytes. In addition, only p65-Thr435 phosphorylation was increased in endothelial cells accompanied by SMI-71 expression (an endothelial barrier antigen). Neutralization of TNF-α by soluble TNF p55 receptor (sTNFp55R) infusion attenuated SE-induced vasogenic edema and neuronal damages via inhibition of p65-Thr435 phosphorylation in endothelial cells. Furthermore, sTNFp55R infusion reduced SE-induced neutrophil infiltration in the PC."}

{"project":"sentences","denotations":[{"id":"T114","span":{"begin":528,"end":612},"obj":"Sentence"},{"id":"T113","span":{"begin":330,"end":527},"obj":"Sentence"},{"id":"T112","span":{"begin":183,"end":329},"obj":"Sentence"},{"id":"T111","span":{"begin":85,"end":182},"obj":"Sentence"},{"id":"T110","span":{"begin":8,"end":84},"obj":"Sentence"},{"id":"T109","span":{"begin":0,"end":7},"obj":"Sentence"},{"id":"T9","span":{"begin":0,"end":7},"obj":"Sentence"},{"id":"T10","span":{"begin":8,"end":84},"obj":"Sentence"},{"id":"T11","span":{"begin":85,"end":182},"obj":"Sentence"},{"id":"T12","span":{"begin":183,"end":329},"obj":"Sentence"},{"id":"T13","span":{"begin":330,"end":527},"obj":"Sentence"},{"id":"T14","span":{"begin":528,"end":612},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Results\nFollowing SE, most activated microglia showed strong TNF-α immunoreactivity. In addition, TNF p75 receptor expression was detected in endothelial cells as well as astrocytes. In addition, only p65-Thr435 phosphorylation was increased in endothelial cells accompanied by SMI-71 expression (an endothelial barrier antigen). Neutralization of TNF-α by soluble TNF p55 receptor (sTNFp55R) infusion attenuated SE-induced vasogenic edema and neuronal damages via inhibition of p65-Thr435 phosphorylation in endothelial cells. Furthermore, sTNFp55R infusion reduced SE-induced neutrophil infiltration in the PC."}

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{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T870","span":{"begin":541,"end":549},"obj":"Protein"},{"id":"T869","span":{"begin":465,"end":475},"obj":"Negative_regulation"},{"id":"T868","span":{"begin":465,"end":475},"obj":"Negative_regulation"},{"id":"T867","span":{"begin":490,"end":505},"obj":"Phosphorylation"},{"id":"T866","span":{"begin":490,"end":505},"obj":"Phosphorylation"},{"id":"T865","span":{"begin":330,"end":344},"obj":"Negative_regulation"},{"id":"T864","span":{"begin":483,"end":489},"obj":"Protein"},{"id":"T863","span":{"begin":479,"end":482},"obj":"Protein"},{"id":"T862","span":{"begin":383,"end":391},"obj":"Protein"},{"id":"T861","span":{"begin":365,"end":381},"obj":"Protein"},{"id":"T860","span":{"begin":348,"end":353},"obj":"Protein"},{"id":"T859","span":{"begin":232,"end":241},"obj":"Positive_regulation"},{"id":"T858","span":{"begin":232,"end":241},"obj":"Positive_regulation"},{"id":"T857","span":{"begin":212,"end":227},"obj":"Phosphorylation"},{"id":"T856","span":{"begin":212,"end":227},"obj":"Phosphorylation"},{"id":"T855","span":{"begin":205,"end":211},"obj":"Protein"},{"id":"T854","span":{"begin":201,"end":204},"obj":"Protein"},{"id":"T853","span":{"begin":115,"end":125},"obj":"Gene_expression"},{"id":"T852","span":{"begin":98,"end":114},"obj":"Protein"},{"id":"T851","span":{"begin":61,"end":66},"obj":"Protein"}],"relations":[{"id":"R576","pred":"themeOf","subj":"T866","obj":"T868"},{"id":"R577","pred":"themeOf","subj":"T867","obj":"T869"},{"id":"R578","pred":"Cause","subj":"T868","obj":"T865"},{"id":"R579","pred":"Cause","subj":"T869","obj":"T865"},{"id":"R568","pred":"themeOf","subj":"T852","obj":"T853"},{"id":"R569","pred":"themeOf","subj":"T854","obj":"T856"},{"id":"R570","pred":"themeOf","subj":"T855","obj":"T857"},{"id":"R571","pred":"themeOf","subj":"T856","obj":"T858"},{"id":"R572","pred":"themeOf","subj":"T857","obj":"T859"},{"id":"R573","pred":"themeOf","subj":"T860","obj":"T865"},{"id":"R574","pred":"themeOf","subj":"T863","obj":"T866"},{"id":"R575","pred":"themeOf","subj":"T864","obj":"T867"}],"text":"Results\nFollowing SE, most activated microglia showed strong TNF-α immunoreactivity. In addition, TNF p75 receptor expression was detected in endothelial cells as well as astrocytes. In addition, only p65-Thr435 phosphorylation was increased in endothelial cells accompanied by SMI-71 expression (an endothelial barrier antigen). Neutralization of TNF-α by soluble TNF p55 receptor (sTNFp55R) infusion attenuated SE-induced vasogenic edema and neuronal damages via inhibition of p65-Thr435 phosphorylation in endothelial cells. Furthermore, sTNFp55R infusion reduced SE-induced neutrophil infiltration in the PC."}

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{"project":"test3","denotations":[{"id":"T89","span":{"begin":541,"end":549},"obj":"Protein"},{"id":"T88","span":{"begin":490,"end":505},"obj":"Phosphorylation"},{"id":"T87","span":{"begin":479,"end":482},"obj":"Protein"},{"id":"T86","span":{"begin":465,"end":475},"obj":"Negative_regulation"},{"id":"T85","span":{"begin":383,"end":391},"obj":"Protein"},{"id":"T84","span":{"begin":365,"end":381},"obj":"Protein"},{"id":"T83","span":{"begin":348,"end":353},"obj":"Protein"},{"id":"T82","span":{"begin":330,"end":344},"obj":"Negative_regulation"},{"id":"T81","span":{"begin":285,"end":295},"obj":"Gene_expression"},{"id":"T80","span":{"begin":232,"end":241},"obj":"Positive_regulation"},{"id":"T79","span":{"begin":212,"end":227},"obj":"Phosphorylation"},{"id":"T78","span":{"begin":201,"end":204},"obj":"Protein"},{"id":"T77","span":{"begin":115,"end":125},"obj":"Gene_expression"},{"id":"T76","span":{"begin":98,"end":114},"obj":"Protein"},{"id":"T75","span":{"begin":61,"end":66},"obj":"Protein"},{"id":"T55","span":{"begin":61,"end":66},"obj":"Protein"},{"id":"T56","span":{"begin":98,"end":114},"obj":"Protein"},{"id":"T57","span":{"begin":201,"end":204},"obj":"Protein"},{"id":"T58","span":{"begin":348,"end":353},"obj":"Protein"},{"id":"T59","span":{"begin":365,"end":381},"obj":"Protein"},{"id":"T60","span":{"begin":384,"end":391},"obj":"Protein"},{"id":"T61","span":{"begin":479,"end":482},"obj":"Protein"},{"id":"T62","span":{"begin":542,"end":549},"obj":"Protein"}],"relations":[{"id":"R27","pred":"causeOf","subj":"T84","obj":"T82"},{"id":"R28","pred":"equivalentTo","subj":"T85","obj":"T84"},{"id":"R29","pred":"themeOf","subj":"T87","obj":"T88"},{"id":"R30","pred":"themeOf","subj":"T88","obj":"T86"},{"id":"R22","pred":"themeOf","subj":"T76","obj":"T77"},{"id":"R23","pred":"themeOf","subj":"T78","obj":"T79"},{"id":"R24","pred":"themeOf","subj":"T79","obj":"T80"},{"id":"R25","pred":"causeOf","subj":"T81","obj":"T80"},{"id":"R26","pred":"themeOf","subj":"T83","obj":"T82"}],"text":"Results\nFollowing SE, most activated microglia showed strong TNF-α immunoreactivity. In addition, TNF p75 receptor expression was detected in endothelial cells as well as astrocytes. In addition, only p65-Thr435 phosphorylation was increased in endothelial cells accompanied by SMI-71 expression (an endothelial barrier antigen). Neutralization of TNF-α by soluble TNF p55 receptor (sTNFp55R) infusion attenuated SE-induced vasogenic edema and neuronal damages via inhibition of p65-Thr435 phosphorylation in endothelial cells. Furthermore, sTNFp55R infusion reduced SE-induced neutrophil infiltration in the PC."}