PMC:3312845 / 18180-19409 JSONTXT

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and TNF receptor expression\nIn non-SE induced animals of the saline-infused groups, TNF-α immunoreactivity was weakly detected in PC neurons (data not shown). In 12 hr-post SE animals of the saline-infused group, most of the activated microglia showed strong TNF-α immunoreactivity (Figure 1A). This expression pattern was maintained up to 1 week after SE. In non-SE-induced animals of the saline-infused groups, TNFp55R and TNFp75R immunoreactivities were also weakly observed in astrocytes (data not shown). In 12 hr-post SE animals of the saline-infused group, TNFp55R immunoreactivity was observed in astrocytes (Figure 1B). Unlike TNFp55R, TNFp75R immunoreactivity was detected in endothelial cells as well as astrocytes (Figures 1C-E). One day to 1 week after SE, both TNFp55R and TNFp75R immunoreactivities were significantly reduced in astrocytes, not in endothelial cells, due to massive astroglial loss (data not shown) [5,7,8,20].\nFigure 1 Expression of TNF-α and TNF receptor in the PC 12 hr-post SE. (A) TNF-α immunoreactivity in Ox-42-positive microglia (arrows). (B) TNFp55R expression in astrocytes (arrows). (C-D) TNFp75R expression in astrocytes as well as endothelial cells (arrows). Bar = 25 (A-D) μm."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T14499","span":{"begin":1139,"end":1146},"obj":"Protein"},{"id":"T14498","span":{"begin":1090,"end":1097},"obj":"Protein"},{"id":"T14497","span":{"begin":1025,"end":1030},"obj":"Protein"},{"id":"T14496","span":{"begin":973,"end":978},"obj":"Protein"},{"id":"T7853","span":{"begin":794,"end":801},"obj":"Protein"},{"id":"T7852","span":{"begin":782,"end":789},"obj":"Protein"},{"id":"T7851","span":{"begin":652,"end":659},"obj":"Protein"},{"id":"T7850","span":{"begin":643,"end":650},"obj":"Protein"},{"id":"T7849","span":{"begin":571,"end":578},"obj":"Protein"},{"id":"T7848","span":{"begin":432,"end":439},"obj":"Protein"},{"id":"T7847","span":{"begin":420,"end":427},"obj":"Protein"},{"id":"T7846","span":{"begin":266,"end":271},"obj":"Protein"},{"id":"T7845","span":{"begin":91,"end":96},"obj":"Protein"},{"id":"T7844","span":{"begin":0,"end":5},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"TNF-α, and TNF receptor expression\nIn non-SE induced animals of the saline-infused groups, TNF-α immunoreactivity was weakly detected in PC neurons (data not shown). In 12 hr-post SE animals of the saline-infused group, most of the activated microglia showed strong TNF-α immunoreactivity (Figure 1A). This expression pattern was maintained up to 1 week after SE. In non-SE-induced animals of the saline-infused groups, TNFp55R and TNFp75R immunoreactivities were also weakly observed in astrocytes (data not shown). In 12 hr-post SE animals of the saline-infused group, TNFp55R immunoreactivity was observed in astrocytes (Figure 1B). Unlike TNFp55R, TNFp75R immunoreactivity was detected in endothelial cells as well as astrocytes (Figures 1C-E). One day to 1 week after SE, both TNFp55R and TNFp75R immunoreactivities were significantly reduced in astrocytes, not in endothelial cells, due to massive astroglial loss (data not shown) [5,7,8,20].\nFigure 1 Expression of TNF-α and TNF receptor in the PC 12 hr-post SE. (A) TNF-α immunoreactivity in Ox-42-positive microglia (arrows). (B) TNFp55R expression in astrocytes (arrows). (C-D) TNFp75R expression in astrocytes as well as endothelial cells (arrows). Bar = 25 (A-D) μm."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T14572","span":{"begin":1025,"end":1030},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T14571","span":{"begin":973,"end":978},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T14570","span":{"begin":983,"end":986},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T14569","span":{"begin":973,"end":976},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T8031","span":{"begin":266,"end":271},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T8030","span":{"begin":91,"end":96},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T8029","span":{"begin":0,"end":5},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T8028","span":{"begin":91,"end":94},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T8027","span":{"begin":11,"end":14},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T8026","span":{"begin":0,"end":3},"obj":"http://www.uniprot.org/uniprot/P01375"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"TNF-α, and TNF receptor expression\nIn non-SE induced animals of the saline-infused groups, TNF-α immunoreactivity was weakly detected in PC neurons (data not shown). In 12 hr-post SE animals of the saline-infused group, most of the activated microglia showed strong TNF-α immunoreactivity (Figure 1A). This expression pattern was maintained up to 1 week after SE. In non-SE-induced animals of the saline-infused groups, TNFp55R and TNFp75R immunoreactivities were also weakly observed in astrocytes (data not shown). In 12 hr-post SE animals of the saline-infused group, TNFp55R immunoreactivity was observed in astrocytes (Figure 1B). Unlike TNFp55R, TNFp75R immunoreactivity was detected in endothelial cells as well as astrocytes (Figures 1C-E). One day to 1 week after SE, both TNFp55R and TNFp75R immunoreactivities were significantly reduced in astrocytes, not in endothelial cells, due to massive astroglial loss (data not shown) [5,7,8,20].\nFigure 1 Expression of TNF-α and TNF receptor in the PC 12 hr-post SE. (A) TNF-α immunoreactivity in Ox-42-positive microglia (arrows). (B) TNFp55R expression in astrocytes (arrows). (C-D) TNFp75R expression in astrocytes as well as endothelial cells (arrows). Bar = 25 (A-D) μm."}

{"project":"GO-CC","denotations":[{"id":"T14500","span":{"begin":1195,"end":1200},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T7855","span":{"begin":882,"end":887},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T7854","span":{"begin":705,"end":710},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"TNF-α, and TNF receptor expression\nIn non-SE induced animals of the saline-infused groups, TNF-α immunoreactivity was weakly detected in PC neurons (data not shown). In 12 hr-post SE animals of the saline-infused group, most of the activated microglia showed strong TNF-α immunoreactivity (Figure 1A). This expression pattern was maintained up to 1 week after SE. In non-SE-induced animals of the saline-infused groups, TNFp55R and TNFp75R immunoreactivities were also weakly observed in astrocytes (data not shown). In 12 hr-post SE animals of the saline-infused group, TNFp55R immunoreactivity was observed in astrocytes (Figure 1B). Unlike TNFp55R, TNFp75R immunoreactivity was detected in endothelial cells as well as astrocytes (Figures 1C-E). One day to 1 week after SE, both TNFp55R and TNFp75R immunoreactivities were significantly reduced in astrocytes, not in endothelial cells, due to massive astroglial loss (data not shown) [5,7,8,20].\nFigure 1 Expression of TNF-α and TNF receptor in the PC 12 hr-post SE. (A) TNF-α immunoreactivity in Ox-42-positive microglia (arrows). (B) TNFp55R expression in astrocytes (arrows). (C-D) TNFp75R expression in astrocytes as well as endothelial cells (arrows). Bar = 25 (A-D) μm."}

{"project":"sentences","denotations":[{"id":"T14489","span":{"begin":1211,"end":1229},"obj":"Sentence"},{"id":"T14488","span":{"begin":959,"end":1210},"obj":"Sentence"},{"id":"T7830","span":{"begin":749,"end":948},"obj":"Sentence"},{"id":"T7829","span":{"begin":636,"end":748},"obj":"Sentence"},{"id":"T7828","span":{"begin":517,"end":635},"obj":"Sentence"},{"id":"T7827","span":{"begin":364,"end":516},"obj":"Sentence"},{"id":"T7826","span":{"begin":302,"end":363},"obj":"Sentence"},{"id":"T7825","span":{"begin":166,"end":301},"obj":"Sentence"},{"id":"T7824","span":{"begin":35,"end":165},"obj":"Sentence"},{"id":"T7823","span":{"begin":0,"end":34},"obj":"Sentence"},{"id":"T143","span":{"begin":0,"end":34},"obj":"Sentence"},{"id":"T144","span":{"begin":35,"end":165},"obj":"Sentence"},{"id":"T145","span":{"begin":166,"end":301},"obj":"Sentence"},{"id":"T146","span":{"begin":302,"end":363},"obj":"Sentence"},{"id":"T147","span":{"begin":364,"end":516},"obj":"Sentence"},{"id":"T148","span":{"begin":517,"end":635},"obj":"Sentence"},{"id":"T149","span":{"begin":636,"end":748},"obj":"Sentence"},{"id":"T150","span":{"begin":749,"end":948},"obj":"Sentence"},{"id":"T151","span":{"begin":949,"end":1210},"obj":"Sentence"},{"id":"T152","span":{"begin":1211,"end":1229},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"TNF-α, and TNF receptor expression\nIn non-SE induced animals of the saline-infused groups, TNF-α immunoreactivity was weakly detected in PC neurons (data not shown). In 12 hr-post SE animals of the saline-infused group, most of the activated microglia showed strong TNF-α immunoreactivity (Figure 1A). This expression pattern was maintained up to 1 week after SE. In non-SE-induced animals of the saline-infused groups, TNFp55R and TNFp75R immunoreactivities were also weakly observed in astrocytes (data not shown). In 12 hr-post SE animals of the saline-infused group, TNFp55R immunoreactivity was observed in astrocytes (Figure 1B). Unlike TNFp55R, TNFp75R immunoreactivity was detected in endothelial cells as well as astrocytes (Figures 1C-E). One day to 1 week after SE, both TNFp55R and TNFp75R immunoreactivities were significantly reduced in astrocytes, not in endothelial cells, due to massive astroglial loss (data not shown) [5,7,8,20].\nFigure 1 Expression of TNF-α and TNF receptor in the PC 12 hr-post SE. (A) TNF-α immunoreactivity in Ox-42-positive microglia (arrows). (B) TNFp55R expression in astrocytes (arrows). (C-D) TNFp75R expression in astrocytes as well as endothelial cells (arrows). Bar = 25 (A-D) μm."}

{"project":"simple1","denotations":[{"id":"T14504","span":{"begin":1139,"end":1146},"obj":"Protein"},{"id":"T14503","span":{"begin":1090,"end":1097},"obj":"Protein"},{"id":"T14502","span":{"begin":1025,"end":1030},"obj":"Protein"},{"id":"T14501","span":{"begin":973,"end":978},"obj":"Protein"},{"id":"T7865","span":{"begin":794,"end":801},"obj":"Protein"},{"id":"T7864","span":{"begin":782,"end":789},"obj":"Protein"},{"id":"T7863","span":{"begin":652,"end":659},"obj":"Protein"},{"id":"T7862","span":{"begin":643,"end":650},"obj":"Protein"},{"id":"T7861","span":{"begin":571,"end":578},"obj":"Protein"},{"id":"T7860","span":{"begin":432,"end":439},"obj":"Protein"},{"id":"T7859","span":{"begin":420,"end":427},"obj":"Protein"},{"id":"T7858","span":{"begin":266,"end":271},"obj":"Protein"},{"id":"T7857","span":{"begin":91,"end":96},"obj":"Protein"},{"id":"T7856","span":{"begin":0,"end":5},"obj":"Protein"}],"text":"TNF-α, and TNF receptor expression\nIn non-SE induced animals of the saline-infused groups, TNF-α immunoreactivity was weakly detected in PC neurons (data not shown). In 12 hr-post SE animals of the saline-infused group, most of the activated microglia showed strong TNF-α immunoreactivity (Figure 1A). This expression pattern was maintained up to 1 week after SE. In non-SE-induced animals of the saline-infused groups, TNFp55R and TNFp75R immunoreactivities were also weakly observed in astrocytes (data not shown). In 12 hr-post SE animals of the saline-infused group, TNFp55R immunoreactivity was observed in astrocytes (Figure 1B). Unlike TNFp55R, TNFp75R immunoreactivity was detected in endothelial cells as well as astrocytes (Figures 1C-E). One day to 1 week after SE, both TNFp55R and TNFp75R immunoreactivities were significantly reduced in astrocytes, not in endothelial cells, due to massive astroglial loss (data not shown) [5,7,8,20].\nFigure 1 Expression of TNF-α and TNF receptor in the PC 12 hr-post SE. (A) TNF-α immunoreactivity in Ox-42-positive microglia (arrows). (B) TNFp55R expression in astrocytes (arrows). (C-D) TNFp75R expression in astrocytes as well as endothelial cells (arrows). Bar = 25 (A-D) μm."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T14669","span":{"begin":1147,"end":1157},"obj":"Gene_expression"},{"id":"T14668","span":{"begin":1098,"end":1108},"obj":"Gene_expression"},{"id":"T14667","span":{"begin":959,"end":969},"obj":"Gene_expression"},{"id":"T14666","span":{"begin":1139,"end":1146},"obj":"Protein"},{"id":"T14665","span":{"begin":1090,"end":1097},"obj":"Protein"},{"id":"T14664","span":{"begin":1025,"end":1030},"obj":"Protein"},{"id":"T14663","span":{"begin":973,"end":978},"obj":"Protein"},{"id":"T8276","span":{"begin":840,"end":847},"obj":"Negative_regulation"},{"id":"T8275","span":{"begin":24,"end":34},"obj":"Gene_expression"},{"id":"T8274","span":{"begin":782,"end":789},"obj":"Protein"},{"id":"T8273","span":{"begin":794,"end":801},"obj":"Protein"},{"id":"T8272","span":{"begin":652,"end":659},"obj":"Protein"},{"id":"T8271","span":{"begin":643,"end":650},"obj":"Protein"},{"id":"T8270","span":{"begin":571,"end":578},"obj":"Protein"},{"id":"T8269","span":{"begin":432,"end":439},"obj":"Protein"},{"id":"T8268","span":{"begin":420,"end":427},"obj":"Protein"},{"id":"T8267","span":{"begin":266,"end":271},"obj":"Protein"},{"id":"T8266","span":{"begin":91,"end":96},"obj":"Protein"},{"id":"T8265","span":{"begin":0,"end":5},"obj":"Protein"}],"relations":[{"id":"R6895","pred":"themeOf","subj":"T8265","obj":"T8275"},{"id":"R6896","pred":"themeOf","subj":"T8273","obj":"T8276"},{"id":"R6897","pred":"themeOf","subj":"T8274","obj":"T8276"},{"id":"R11357","pred":"themeOf","subj":"T14663","obj":"T14667"},{"id":"R11358","pred":"themeOf","subj":"T14665","obj":"T14668"},{"id":"R11359","pred":"themeOf","subj":"T14666","obj":"T14669"}],"text":"TNF-α, and TNF receptor expression\nIn non-SE induced animals of the saline-infused groups, TNF-α immunoreactivity was weakly detected in PC neurons (data not shown). In 12 hr-post SE animals of the saline-infused group, most of the activated microglia showed strong TNF-α immunoreactivity (Figure 1A). This expression pattern was maintained up to 1 week after SE. In non-SE-induced animals of the saline-infused groups, TNFp55R and TNFp75R immunoreactivities were also weakly observed in astrocytes (data not shown). In 12 hr-post SE animals of the saline-infused group, TNFp55R immunoreactivity was observed in astrocytes (Figure 1B). Unlike TNFp55R, TNFp75R immunoreactivity was detected in endothelial cells as well as astrocytes (Figures 1C-E). One day to 1 week after SE, both TNFp55R and TNFp75R immunoreactivities were significantly reduced in astrocytes, not in endothelial cells, due to massive astroglial loss (data not shown) [5,7,8,20].\nFigure 1 Expression of TNF-α and TNF receptor in the PC 12 hr-post SE. (A) TNF-α immunoreactivity in Ox-42-positive microglia (arrows). (B) TNFp55R expression in astrocytes (arrows). (C-D) TNFp75R expression in astrocytes as well as endothelial cells (arrows). Bar = 25 (A-D) μm."}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T14627","span":{"begin":1139,"end":1146},"obj":"Protein"},{"id":"T14626","span":{"begin":1090,"end":1097},"obj":"Protein"},{"id":"T14625","span":{"begin":1025,"end":1030},"obj":"Protein"},{"id":"T14624","span":{"begin":973,"end":978},"obj":"Protein"},{"id":"T8206","span":{"begin":652,"end":659},"obj":"Protein"},{"id":"T8205","span":{"begin":643,"end":650},"obj":"Protein"},{"id":"T8204","span":{"begin":571,"end":578},"obj":"Protein"},{"id":"T8203","span":{"begin":432,"end":439},"obj":"Protein"},{"id":"T8202","span":{"begin":420,"end":427},"obj":"Protein"},{"id":"T8201","span":{"begin":266,"end":271},"obj":"Protein"},{"id":"T8200","span":{"begin":91,"end":96},"obj":"Protein"},{"id":"T8199","span":{"begin":0,"end":5},"obj":"Protein"},{"id":"T8210","span":{"begin":840,"end":847},"obj":"Negative_regulation"},{"id":"T8209","span":{"begin":24,"end":34},"obj":"Gene_expression"},{"id":"T8208","span":{"begin":782,"end":789},"obj":"Protein"},{"id":"T8207","span":{"begin":794,"end":801},"obj":"Protein"},{"id":"T14630","span":{"begin":1147,"end":1157},"obj":"Gene_expression"},{"id":"T14629","span":{"begin":1098,"end":1108},"obj":"Gene_expression"},{"id":"T14628","span":{"begin":959,"end":969},"obj":"Gene_expression"}],"relations":[{"id":"R6879","pred":"themeOf","subj":"T8199","obj":"T8209"},{"id":"R6880","pred":"themeOf","subj":"T8208","obj":"T8210"},{"id":"R11340","pred":"themeOf","subj":"T14624","obj":"T14628"},{"id":"R11341","pred":"themeOf","subj":"T14626","obj":"T14629"},{"id":"R11342","pred":"themeOf","subj":"T14627","obj":"T14630"}],"text":"TNF-α, and TNF receptor expression\nIn non-SE induced animals of the saline-infused groups, TNF-α immunoreactivity was weakly detected in PC neurons (data not shown). In 12 hr-post SE animals of the saline-infused group, most of the activated microglia showed strong TNF-α immunoreactivity (Figure 1A). This expression pattern was maintained up to 1 week after SE. In non-SE-induced animals of the saline-infused groups, TNFp55R and TNFp75R immunoreactivities were also weakly observed in astrocytes (data not shown). In 12 hr-post SE animals of the saline-infused group, TNFp55R immunoreactivity was observed in astrocytes (Figure 1B). Unlike TNFp55R, TNFp75R immunoreactivity was detected in endothelial cells as well as astrocytes (Figures 1C-E). One day to 1 week after SE, both TNFp55R and TNFp75R immunoreactivities were significantly reduced in astrocytes, not in endothelial cells, due to massive astroglial loss (data not shown) [5,7,8,20].\nFigure 1 Expression of TNF-α and TNF receptor in the PC 12 hr-post SE. (A) TNF-α immunoreactivity in Ox-42-positive microglia (arrows). (B) TNFp55R expression in astrocytes (arrows). (C-D) TNFp75R expression in astrocytes as well as endothelial cells (arrows). Bar = 25 (A-D) μm."}

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and TNF receptor expression\nIn non-SE induced animals of the saline-infused groups, TNF-α immunoreactivity was weakly detected in PC neurons (data not shown). In 12 hr-post SE animals of the saline-infused group, most of the activated microglia showed strong TNF-α immunoreactivity (Figure 1A). This expression pattern was maintained up to 1 week after SE. In non-SE-induced animals of the saline-infused groups, TNFp55R and TNFp75R immunoreactivities were also weakly observed in astrocytes (data not shown). In 12 hr-post SE animals of the saline-infused group, TNFp55R immunoreactivity was observed in astrocytes (Figure 1B). Unlike TNFp55R, TNFp75R immunoreactivity was detected in endothelial cells as well as astrocytes (Figures 1C-E). One day to 1 week after SE, both TNFp55R and TNFp75R immunoreactivities were significantly reduced in astrocytes, not in endothelial cells, due to massive astroglial loss (data not shown) [5,7,8,20].\nFigure 1 Expression of TNF-α and TNF receptor in the PC 12 hr-post SE. (A) TNF-α immunoreactivity in Ox-42-positive microglia (arrows). (B) TNFp55R expression in astrocytes (arrows). (C-D) TNFp75R expression in astrocytes as well as endothelial cells (arrows). Bar = 25 (A-D) μm."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T14650","span":{"begin":1090,"end":1097},"obj":"Protein"},{"id":"T14649","span":{"begin":1025,"end":1030},"obj":"Protein"},{"id":"T14648","span":{"begin":959,"end":969},"obj":"Gene_expression"},{"id":"T14647","span":{"begin":959,"end":969},"obj":"Gene_expression"},{"id":"T14646","span":{"begin":983,"end":995},"obj":"Protein"},{"id":"T14645","span":{"begin":973,"end":978},"obj":"Protein"},{"id":"T14653","span":{"begin":1147,"end":1157},"obj":"Gene_expression"},{"id":"T14652","span":{"begin":1139,"end":1146},"obj":"Protein"},{"id":"T14651","span":{"begin":1098,"end":1108},"obj":"Gene_expression"},{"id":"T8249","span":{"begin":840,"end":847},"obj":"Negative_regulation"},{"id":"T8248","span":{"begin":840,"end":847},"obj":"Negative_regulation"},{"id":"T8247","span":{"begin":794,"end":801},"obj":"Protein"},{"id":"T8246","span":{"begin":782,"end":789},"obj":"Protein"},{"id":"T8245","span":{"begin":652,"end":659},"obj":"Protein"},{"id":"T8244","span":{"begin":643,"end":650},"obj":"Protein"},{"id":"T8243","span":{"begin":571,"end":578},"obj":"Protein"},{"id":"T8242","span":{"begin":432,"end":439},"obj":"Protein"},{"id":"T8241","span":{"begin":420,"end":427},"obj":"Protein"},{"id":"T8240","span":{"begin":266,"end":271},"obj":"Protein"},{"id":"T8239","span":{"begin":91,"end":96},"obj":"Protein"},{"id":"T8238","span":{"begin":24,"end":34},"obj":"Gene_expression"},{"id":"T8237","span":{"begin":24,"end":34},"obj":"Gene_expression"},{"id":"T8236","span":{"begin":11,"end":23},"obj":"Protein"},{"id":"T8235","span":{"begin":0,"end":5},"obj":"Protein"}],"relations":[{"id":"R6887","pred":"themeOf","subj":"T8235","obj":"T8237"},{"id":"R6888","pred":"themeOf","subj":"T8236","obj":"T8238"},{"id":"R6889","pred":"themeOf","subj":"T8246","obj":"T8248"},{"id":"R6890","pred":"themeOf","subj":"T8247","obj":"T8249"},{"id":"R11349","pred":"themeOf","subj":"T14645","obj":"T14647"},{"id":"R11350","pred":"themeOf","subj":"T14646","obj":"T14648"},{"id":"R11351","pred":"themeOf","subj":"T14650","obj":"T14651"},{"id":"R11352","pred":"themeOf","subj":"T14652","obj":"T14653"}],"text":"TNF-α, and TNF receptor expression\nIn non-SE induced animals of the saline-infused groups, TNF-α immunoreactivity was weakly detected in PC neurons (data not shown). In 12 hr-post SE animals of the saline-infused group, most of the activated microglia showed strong TNF-α immunoreactivity (Figure 1A). This expression pattern was maintained up to 1 week after SE. In non-SE-induced animals of the saline-infused groups, TNFp55R and TNFp75R immunoreactivities were also weakly observed in astrocytes (data not shown). In 12 hr-post SE animals of the saline-infused group, TNFp55R immunoreactivity was observed in astrocytes (Figure 1B). Unlike TNFp55R, TNFp75R immunoreactivity was detected in endothelial cells as well as astrocytes (Figures 1C-E). One day to 1 week after SE, both TNFp55R and TNFp75R immunoreactivities were significantly reduced in astrocytes, not in endothelial cells, due to massive astroglial loss (data not shown) [5,7,8,20].\nFigure 1 Expression of TNF-α and TNF receptor in the PC 12 hr-post SE. (A) TNF-α immunoreactivity in Ox-42-positive microglia (arrows). (B) TNFp55R expression in astrocytes (arrows). (C-D) TNFp75R expression in astrocytes as well as endothelial cells (arrows). Bar = 25 (A-D) μm."}

{"project":"testone","denotations":[{"id":"T14477","span":{"begin":1147,"end":1157},"obj":"Gene_expression"},{"id":"T14476","span":{"begin":1057,"end":1065},"obj":"Gene_expression"},{"id":"T14475","span":{"begin":959,"end":969},"obj":"Gene_expression"},{"id":"T14474","span":{"begin":1139,"end":1146},"obj":"Protein"},{"id":"T14473","span":{"begin":1090,"end":1097},"obj":"Protein"},{"id":"T14472","span":{"begin":1025,"end":1030},"obj":"Protein"},{"id":"T14471","span":{"begin":973,"end":978},"obj":"Protein"},{"id":"T7800","span":{"begin":840,"end":847},"obj":"Negative_regulation"},{"id":"T7799","span":{"begin":24,"end":34},"obj":"Gene_expression"},{"id":"T7798","span":{"begin":794,"end":801},"obj":"Protein"},{"id":"T7797","span":{"begin":782,"end":789},"obj":"Protein"},{"id":"T7796","span":{"begin":652,"end":659},"obj":"Protein"},{"id":"T7795","span":{"begin":643,"end":650},"obj":"Protein"},{"id":"T7794","span":{"begin":571,"end":578},"obj":"Protein"},{"id":"T7793","span":{"begin":432,"end":439},"obj":"Protein"},{"id":"T7792","span":{"begin":420,"end":427},"obj":"Protein"},{"id":"T7791","span":{"begin":266,"end":271},"obj":"Protein"},{"id":"T7790","span":{"begin":91,"end":96},"obj":"Protein"},{"id":"T7789","span":{"begin":0,"end":5},"obj":"Protein"}],"relations":[{"id":"R6541","pred":"themeOf","subj":"T7789","obj":"T7799"},{"id":"R6542","pred":"themeOf","subj":"T7797","obj":"T7800"},{"id":"R6543","pred":"themeOf","subj":"T7798","obj":"T7800"},{"id":"R11221","pred":"themeOf","subj":"T14471","obj":"T14475"},{"id":"R11222","pred":"themeOf","subj":"T14474","obj":"T14477"}],"text":"TNF-α, and TNF receptor expression\nIn non-SE induced animals of the saline-infused groups, TNF-α immunoreactivity was weakly detected in PC neurons (data not shown). In 12 hr-post SE animals of the saline-infused group, most of the activated microglia showed strong TNF-α immunoreactivity (Figure 1A). This expression pattern was maintained up to 1 week after SE. In non-SE-induced animals of the saline-infused groups, TNFp55R and TNFp75R immunoreactivities were also weakly observed in astrocytes (data not shown). In 12 hr-post SE animals of the saline-infused group, TNFp55R immunoreactivity was observed in astrocytes (Figure 1B). Unlike TNFp55R, TNFp75R immunoreactivity was detected in endothelial cells as well as astrocytes (Figures 1C-E). One day to 1 week after SE, both TNFp55R and TNFp75R immunoreactivities were significantly reduced in astrocytes, not in endothelial cells, due to massive astroglial loss (data not shown) [5,7,8,20].\nFigure 1 Expression of TNF-α and TNF receptor in the PC 12 hr-post SE. (A) TNF-α immunoreactivity in Ox-42-positive microglia (arrows). (B) TNFp55R expression in astrocytes (arrows). (C-D) TNFp75R expression in astrocytes as well as endothelial cells (arrows). Bar = 25 (A-D) μm."}

{"project":"test3","denotations":[{"id":"T14487","span":{"begin":1139,"end":1146},"obj":"Protein"},{"id":"T14486","span":{"begin":1090,"end":1097},"obj":"Protein"},{"id":"T14485","span":{"begin":1057,"end":1065},"obj":"Gene_expression"},{"id":"T14484","span":{"begin":1025,"end":1030},"obj":"Protein"},{"id":"T14483","span":{"begin":973,"end":978},"obj":"Protein"},{"id":"T14482","span":{"begin":959,"end":969},"obj":"Gene_expression"},{"id":"T14481","span":{"begin":1139,"end":1146},"obj":"Protein"},{"id":"T14480","span":{"begin":1090,"end":1097},"obj":"Protein"},{"id":"T14479","span":{"begin":1025,"end":1030},"obj":"Protein"},{"id":"T14478","span":{"begin":973,"end":978},"obj":"Protein"},{"id":"T7822","span":{"begin":840,"end":847},"obj":"Negative_regulation"},{"id":"T7821","span":{"begin":794,"end":801},"obj":"Protein"},{"id":"T7820","span":{"begin":782,"end":789},"obj":"Protein"},{"id":"T7819","span":{"begin":652,"end":659},"obj":"Protein"},{"id":"T7818","span":{"begin":643,"end":650},"obj":"Protein"},{"id":"T7817","span":{"begin":571,"end":578},"obj":"Protein"},{"id":"T7816","span":{"begin":432,"end":439},"obj":"Protein"},{"id":"T7815","span":{"begin":420,"end":427},"obj":"Protein"},{"id":"T7814","span":{"begin":266,"end":271},"obj":"Protein"},{"id":"T7813","span":{"begin":91,"end":96},"obj":"Protein"},{"id":"T7812","span":{"begin":24,"end":34},"obj":"Gene_expression"},{"id":"T7811","span":{"begin":0,"end":5},"obj":"Protein"},{"id":"T7810","span":{"begin":794,"end":801},"obj":"Protein"},{"id":"T7809","span":{"begin":782,"end":789},"obj":"Protein"},{"id":"T7808","span":{"begin":652,"end":659},"obj":"Protein"},{"id":"T7807","span":{"begin":643,"end":650},"obj":"Protein"},{"id":"T7806","span":{"begin":571,"end":578},"obj":"Protein"},{"id":"T7805","span":{"begin":432,"end":439},"obj":"Protein"},{"id":"T7804","span":{"begin":420,"end":427},"obj":"Protein"},{"id":"T7803","span":{"begin":266,"end":271},"obj":"Protein"},{"id":"T7802","span":{"begin":91,"end":96},"obj":"Protein"},{"id":"T7801","span":{"begin":0,"end":5},"obj":"Protein"}],"relations":[{"id":"R6544","pred":"themeOf","subj":"T7811","obj":"T7812"},{"id":"R6545","pred":"themeOf","subj":"T7820","obj":"T7822"},{"id":"R6546","pred":"themeOf","subj":"T7821","obj":"T7822"},{"id":"R11223","pred":"themeOf","subj":"T14483","obj":"T14482"}],"text":"TNF-α, and TNF receptor expression\nIn non-SE induced animals of the saline-infused groups, TNF-α immunoreactivity was weakly detected in PC neurons (data not shown). In 12 hr-post SE animals of the saline-infused group, most of the activated microglia showed strong TNF-α immunoreactivity (Figure 1A). This expression pattern was maintained up to 1 week after SE. In non-SE-induced animals of the saline-infused groups, TNFp55R and TNFp75R immunoreactivities were also weakly observed in astrocytes (data not shown). In 12 hr-post SE animals of the saline-infused group, TNFp55R immunoreactivity was observed in astrocytes (Figure 1B). Unlike TNFp55R, TNFp75R immunoreactivity was detected in endothelial cells as well as astrocytes (Figures 1C-E). One day to 1 week after SE, both TNFp55R and TNFp75R immunoreactivities were significantly reduced in astrocytes, not in endothelial cells, due to massive astroglial loss (data not shown) [5,7,8,20].\nFigure 1 Expression of TNF-α and TNF receptor in the PC 12 hr-post SE. (A) TNF-α immunoreactivity in Ox-42-positive microglia (arrows). (B) TNFp55R expression in astrocytes (arrows). (C-D) TNFp75R expression in astrocytes as well as endothelial cells (arrows). Bar = 25 (A-D) μm."}