PMC:3312845 / 1077-1611 JSONTXT

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as well as astrocytes. In addition, only p65-Thr435 phosphorylation was increased in endothelial cells accompanied by SMI-71 expression (an endothelial barrier antigen). Neutralization of TNF-α by soluble TNF p55 receptor (sTNFp55R) infusion attenuated SE-induced vasogenic edema and neuronal damages via inhibition of p65-Thr435 phosphorylation in endothelial cells. Furthermore, sTNFp55R infusion reduced SE-induced neutrophil infiltration in the PC.\n\nConclusion\nThese findings suggest that impairments of endothelial cell function"}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T153","span":{"begin":42,"end":45},"obj":"Protein"},{"id":"T154","span":{"begin":189,"end":194},"obj":"Protein"},{"id":"T155","span":{"begin":206,"end":222},"obj":"Protein"},{"id":"T156","span":{"begin":225,"end":232},"obj":"Protein"},{"id":"T157","span":{"begin":320,"end":323},"obj":"Protein"},{"id":"T158","span":{"begin":383,"end":390},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":" as well as astrocytes. In addition, only p65-Thr435 phosphorylation was increased in endothelial cells accompanied by SMI-71 expression (an endothelial barrier antigen). Neutralization of TNF-α by soluble TNF p55 receptor (sTNFp55R) infusion attenuated SE-induced vasogenic edema and neuronal damages via inhibition of p65-Thr435 phosphorylation in endothelial cells. Furthermore, sTNFp55R infusion reduced SE-induced neutrophil infiltration in the PC.\n\nConclusion\nThese findings suggest that impairments of endothelial cell function"}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T479","span":{"begin":210,"end":213},"obj":"http://www.uniprot.org/uniprot/P01589"},{"id":"T476","span":{"begin":189,"end":194},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T459","span":{"begin":42,"end":45},"obj":"http://www.uniprot.org/uniprot/Q04206"},{"id":"T460","span":{"begin":320,"end":323},"obj":"http://www.uniprot.org/uniprot/Q04206"},{"id":"T463","span":{"begin":42,"end":45},"obj":"http://www.uniprot.org/uniprot/P21579"},{"id":"T464","span":{"begin":320,"end":323},"obj":"http://www.uniprot.org/uniprot/P21579"},{"id":"T471","span":{"begin":189,"end":192},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T472","span":{"begin":206,"end":209},"obj":"http://www.uniprot.org/uniprot/P01375"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":" as well as astrocytes. In addition, only p65-Thr435 phosphorylation was increased in endothelial cells accompanied by SMI-71 expression (an endothelial barrier antigen). Neutralization of TNF-α by soluble TNF p55 receptor (sTNFp55R) infusion attenuated SE-induced vasogenic edema and neuronal damages via inhibition of p65-Thr435 phosphorylation in endothelial cells. Furthermore, sTNFp55R infusion reduced SE-induced neutrophil infiltration in the PC.\n\nConclusion\nThese findings suggest that impairments of endothelial cell function"}

{"project":"GO-BP","denotations":[{"id":"T171","span":{"begin":331,"end":346},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T170","span":{"begin":53,"end":68},"obj":"http://purl.obolibrary.org/obo/GO_0016310"}],"text":" as well as astrocytes. In addition, only p65-Thr435 phosphorylation was increased in endothelial cells accompanied by SMI-71 expression (an endothelial barrier antigen). Neutralization of TNF-α by soluble TNF p55 receptor (sTNFp55R) infusion attenuated SE-induced vasogenic edema and neuronal damages via inhibition of p65-Thr435 phosphorylation in endothelial cells. Furthermore, sTNFp55R infusion reduced SE-induced neutrophil infiltration in the PC.\n\nConclusion\nThese findings suggest that impairments of endothelial cell function"}

{"project":"GO-CC","denotations":[{"id":"T182","span":{"begin":98,"end":103},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T183","span":{"begin":362,"end":367},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T184","span":{"begin":521,"end":525},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":" as well as astrocytes. In addition, only p65-Thr435 phosphorylation was increased in endothelial cells accompanied by SMI-71 expression (an endothelial barrier antigen). Neutralization of TNF-α by soluble TNF p55 receptor (sTNFp55R) infusion attenuated SE-induced vasogenic edema and neuronal damages via inhibition of p65-Thr435 phosphorylation in endothelial cells. Furthermore, sTNFp55R infusion reduced SE-induced neutrophil infiltration in the PC.\n\nConclusion\nThese findings suggest that impairments of endothelial cell function"}

{"project":"sentences","denotations":[{"id":"T115","span":{"begin":455,"end":465},"obj":"Sentence"},{"id":"T114","span":{"begin":369,"end":453},"obj":"Sentence"},{"id":"T113","span":{"begin":171,"end":368},"obj":"Sentence"},{"id":"T112","span":{"begin":24,"end":170},"obj":"Sentence"},{"id":"T12","span":{"begin":24,"end":170},"obj":"Sentence"},{"id":"T13","span":{"begin":171,"end":368},"obj":"Sentence"},{"id":"T14","span":{"begin":369,"end":453},"obj":"Sentence"},{"id":"T15","span":{"begin":455,"end":465},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":" as well as astrocytes. In addition, only p65-Thr435 phosphorylation was increased in endothelial cells accompanied by SMI-71 expression (an endothelial barrier antigen). Neutralization of TNF-α by soluble TNF p55 receptor (sTNFp55R) infusion attenuated SE-induced vasogenic edema and neuronal damages via inhibition of p65-Thr435 phosphorylation in endothelial cells. Furthermore, sTNFp55R infusion reduced SE-induced neutrophil infiltration in the PC.\n\nConclusion\nThese findings suggest that impairments of endothelial cell function"}

{"project":"simple1","denotations":[{"id":"T198","span":{"begin":383,"end":390},"obj":"Protein"},{"id":"T197","span":{"begin":320,"end":323},"obj":"Protein"},{"id":"T196","span":{"begin":225,"end":232},"obj":"Protein"},{"id":"T195","span":{"begin":206,"end":222},"obj":"Protein"},{"id":"T194","span":{"begin":189,"end":194},"obj":"Protein"},{"id":"T193","span":{"begin":42,"end":45},"obj":"Protein"}],"text":" as well as astrocytes. In addition, only p65-Thr435 phosphorylation was increased in endothelial cells accompanied by SMI-71 expression (an endothelial barrier antigen). Neutralization of TNF-α by soluble TNF p55 receptor (sTNFp55R) infusion attenuated SE-induced vasogenic edema and neuronal damages via inhibition of p65-Thr435 phosphorylation in endothelial cells. Furthermore, sTNFp55R infusion reduced SE-induced neutrophil infiltration in the PC.\n\nConclusion\nThese findings suggest that impairments of endothelial cell function"}

{"project":"BioNLP16_DUT","denotations":[{"id":"T917","span":{"begin":42,"end":45},"obj":"Protein"},{"id":"T918","span":{"begin":189,"end":194},"obj":"Protein"},{"id":"T919","span":{"begin":206,"end":222},"obj":"Protein"},{"id":"T920","span":{"begin":225,"end":232},"obj":"Protein"},{"id":"T921","span":{"begin":320,"end":323},"obj":"Protein"},{"id":"T922","span":{"begin":383,"end":390},"obj":"Protein"},{"id":"T927","span":{"begin":73,"end":82},"obj":"Positive_regulation"},{"id":"T928","span":{"begin":53,"end":68},"obj":"Phosphorylation"},{"id":"T929","span":{"begin":331,"end":346},"obj":"Phosphorylation"},{"id":"T930","span":{"begin":306,"end":316},"obj":"Negative_regulation"},{"id":"T931","span":{"begin":171,"end":185},"obj":"Negative_regulation"}],"relations":[{"id":"R648","pred":"themeOf","subj":"T917","obj":"T928"},{"id":"R649","pred":"themeOf","subj":"T918","obj":"T931"},{"id":"R650","pred":"themeOf","subj":"T921","obj":"T929"},{"id":"R651","pred":"themeOf","subj":"T928","obj":"T927"},{"id":"R652","pred":"themeOf","subj":"T929","obj":"T930"}],"text":" as well as astrocytes. In addition, only p65-Thr435 phosphorylation was increased in endothelial cells accompanied by SMI-71 expression (an endothelial barrier antigen). Neutralization of TNF-α by soluble TNF p55 receptor (sTNFp55R) infusion attenuated SE-induced vasogenic edema and neuronal damages via inhibition of p65-Thr435 phosphorylation in endothelial cells. Furthermore, sTNFp55R infusion reduced SE-induced neutrophil infiltration in the PC.\n\nConclusion\nThese findings suggest that impairments of endothelial cell function"}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T763","span":{"begin":383,"end":390},"obj":"Protein"},{"id":"T762","span":{"begin":320,"end":323},"obj":"Protein"},{"id":"T761","span":{"begin":225,"end":232},"obj":"Protein"},{"id":"T760","span":{"begin":206,"end":222},"obj":"Protein"},{"id":"T759","span":{"begin":189,"end":194},"obj":"Protein"},{"id":"T758","span":{"begin":42,"end":45},"obj":"Protein"},{"id":"T773","span":{"begin":306,"end":316},"obj":"Negative_regulation"},{"id":"T772","span":{"begin":331,"end":346},"obj":"Phosphorylation"},{"id":"T771","span":{"begin":171,"end":185},"obj":"Negative_regulation"},{"id":"T770","span":{"begin":73,"end":82},"obj":"Positive_regulation"},{"id":"T769","span":{"begin":53,"end":68},"obj":"Phosphorylation"}],"relations":[{"id":"R557","pred":"themeOf","subj":"T758","obj":"T769"},{"id":"R558","pred":"themeOf","subj":"T759","obj":"T771"},{"id":"R559","pred":"themeOf","subj":"T762","obj":"T772"},{"id":"R564","pred":"themeOf","subj":"T769","obj":"T770"},{"id":"R565","pred":"themeOf","subj":"T772","obj":"T773"}],"text":" as well as astrocytes. In addition, only p65-Thr435 phosphorylation was increased in endothelial cells accompanied by SMI-71 expression (an endothelial barrier antigen). Neutralization of TNF-α by soluble TNF p55 receptor (sTNFp55R) infusion attenuated SE-induced vasogenic edema and neuronal damages via inhibition of p65-Thr435 phosphorylation in endothelial cells. Furthermore, sTNFp55R infusion reduced SE-induced neutrophil infiltration in the PC.\n\nConclusion\nThese findings suggest that impairments of endothelial cell function"}

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