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PMC:3291650 / 2858-9432 JSONTXT

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test3

Id Subject Object Predicate Lexical cue
T908 5669-5674 Protein denotes IRF-3
T907 5638-5645 Positive_regulation denotes induced
T906 5633-5637 Protein denotes TLR3
T905 5622-5627 Protein denotes RIG-I
T904 5613-5621 Regulation denotes regulate
T903 4764-4773 Negative_regulation denotes deficient
T902 4673-4678 Protein denotes IL-1R
T901 4658-4662 Protein denotes TLR4
T900 4632-4646 Protein denotes TNF receptor I
T899 4204-4209 Protein denotes RBCK1
T898 4188-4194 Protein denotes TRIM21
T897 4177-4181 Protein denotes RAUL
T896 4135-4139 Protein denotes IRF7
T895 4126-4130 Protein denotes IRF3
T894 3994-4005 Protein_catabolism denotes degradation
T893 3964-3969 Protein denotes TRAF3
T892 3955-3959 Protein denotes MAVS
T891 3924-3931 Protein denotes TRIAD3A
T890 3910-3914 Protein denotes AIP4
T889 3744-3747 Protein denotes RLR
T888 3735-3743 Regulation denotes regulate
T887 3672-3676 Protein denotes CYLD
T886 3661-3665 Protein denotes DUBA
T885 3582-3587 Protein denotes RIG-I
T884 3566-3576 Positive_regulation denotes activation
T883 3561-3565 Protein denotes IRF3
T882 3519-3524 Protein denotes TRAF3
T881 3498-3503 Protein denotes TRAF6
T880 3422-3427 Protein denotes RIG-I
T879 3367-3373 Protein denotes Riplet
T878 3351-3357 Protein denotes TRIM25
T877 3264-3269 Protein denotes RIG-I
T876 3153-3157 Protein denotes MAVS
T875 3086-3117 Entity denotes C-terminal transmembrane domain
T874 3014-3026 Localization denotes translocates
T873 2970-2976 Protein denotes Cardif
T872 2964-2968 Protein denotes VISA
T871 2957-2962 Protein denotes IPS-1
T870 2939-2943 Protein denotes MAVS
T869 2901-2910 Binding denotes associate
T868 2895-2900 Protein denotes RIG-I
T867 2866-2873 Binding denotes binding
T866 2723-2728 Protein denotes RIG-I
T865 2477-2486 Negative_regulation denotes deficient
T864 2472-2476 Protein denotes TLR3
T863 2407-2416 Negative_regulation denotes deficient
T862 2401-2406 Protein denotes RIG-I
T861 2355-2360 Protein denotes RIG-I
T860 2145-2150 Protein denotes RIG-I
T859 2136-2140 Protein denotes TLR3
T858 1281-1290 Gene_expression denotes producing
T857 1196-1201 Protein denotes IFI16
T856 1173-1177 Protein denotes AIM2
T855 1124-1127 Protein denotes DAI
T854 1118-1122 Protein denotes TLR9
T853 1022-1026 Protein denotes MDA5
T852 1015-1020 Protein denotes RIG-I
T851 1009-1013 Protein denotes TLR3
T850 979-983 Protein denotes Nod2
T849 973-977 Protein denotes TLR8
T848 967-971 Protein denotes TLR7
T847 603-607 Protein denotes IRF7
T846 594-598 Protein denotes IRF3
T845 471-476 Protein denotes IFN-β
T844 460-465 Protein denotes IFN-α
T843 446-458 Protein denotes interferon-α
T842 416-420 Protein denotes IL-1
T841 407-411 Protein denotes IL-6
T840 402-405 Protein denotes TNF
T839 5669-5674 Protein denotes IRF-3
T838 5633-5637 Protein denotes TLR3
T837 5622-5627 Protein denotes RIG-I
T836 4673-4678 Protein denotes IL-1R
T835 4658-4662 Protein denotes TLR4
T834 4632-4646 Protein denotes TNF receptor I
T833 4204-4209 Protein denotes RBCK1
T832 4188-4194 Protein denotes TRIM21
T831 4177-4181 Protein denotes RAUL
T830 4135-4139 Protein denotes IRF7
T829 4126-4130 Protein denotes IRF3
T828 3964-3969 Protein denotes TRAF3
T827 3955-3959 Protein denotes MAVS
T826 3924-3931 Protein denotes TRIAD3A
T811 2964-2968 Protein denotes VISA
T810 2957-2962 Protein denotes IPS-1
T809 2939-2943 Protein denotes MAVS
T808 2895-2900 Protein denotes RIG-I
T807 2723-2728 Protein denotes RIG-I
T806 2472-2476 Protein denotes TLR3
T805 2401-2406 Protein denotes RIG-I
T804 2355-2360 Protein denotes RIG-I
T803 2145-2150 Protein denotes RIG-I
T802 2136-2140 Protein denotes TLR3
T801 1196-1201 Protein denotes IFI16
T800 1173-1177 Protein denotes AIM2
T799 1124-1127 Protein denotes DAI
T798 1118-1122 Protein denotes TLR9
T797 1022-1026 Protein denotes MDA5
T796 1015-1020 Protein denotes RIG-I
T795 1009-1013 Protein denotes TLR3
T794 979-983 Protein denotes Nod2
T793 973-977 Protein denotes TLR8
T792 967-971 Protein denotes TLR7
T791 603-607 Protein denotes IRF7
T790 594-598 Protein denotes IRF3
T789 471-476 Protein denotes IFN-β
T788 460-465 Protein denotes IFN-α
T787 446-458 Protein denotes interferon-α
T786 416-420 Protein denotes IL-1
T785 407-411 Protein denotes IL-6
T784 402-405 Protein denotes TNF
T825 3910-3914 Protein denotes AIP4
T824 3744-3747 Protein denotes RLR
T823 3672-3676 Protein denotes CYLD
T822 3661-3665 Protein denotes DUBA
T821 3582-3587 Protein denotes RIG-I
T820 3561-3565 Protein denotes IRF3
T819 3519-3524 Protein denotes TRAF3
T818 3498-3503 Protein denotes TRAF6
T817 3422-3427 Protein denotes RIG-I
T816 3367-3373 Protein denotes Riplet
T815 3351-3357 Protein denotes TRIM25
T814 3264-3269 Protein denotes RIG-I
T813 3153-3157 Protein denotes MAVS
T812 2970-2976 Protein denotes Cardif
R531 T844 T843 equivalentTo IFN-α,interferon-α
R532 T862 T863 themeOf RIG-I,deficient
R533 T864 T865 themeOf TLR3,deficient
R534 T868 T869 themeOf RIG-I,associate
R535 T870 T874 themeOf MAVS,translocates
R536 T871 T874 themeOf IPS-1,translocates
R537 T872 T874 themeOf VISA,translocates
R538 T873 T874 themeOf Cardif,translocates
R539 T875 T870 partOf C-terminal transmembrane domain,MAVS
R540 T875 T867 themeOf C-terminal transmembrane domain,binding
R541 T875 T874 themeOf C-terminal transmembrane domain,translocates
R542 T875 T868 partOf C-terminal transmembrane domain,RIG-I
R543 T875 T871 partOf C-terminal transmembrane domain,IPS-1
R544 T875 T873 partOf C-terminal transmembrane domain,Cardif
R545 T881 T884 themeOf TRAF6,activation
R546 T882 T884 themeOf TRAF3,activation
R547 T883 T884 themeOf IRF3,activation
R548 T885 T884 causeOf RIG-I,activation
R549 T905 T907 causeOf RIG-I,induced
R550 T906 T907 causeOf TLR3,induced
R551 T907 T904 themeOf induced,regulate

2_test

Id Subject Object Predicate Lexical cue
22396652-20404851-98461805 609-610 20404851 denotes 1
22396652-20303872-98461806 614-615 20303872 denotes 2
22396652-19120475-98461807 794-795 19120475 denotes 3
22396652-17618271-98461808 1129-1130 17618271 denotes 4
22396652-19158679-98461809 1179-1180 19158679 denotes 5
22396652-19158676-98461810 1184-1185 19158676 denotes 6
22396652-19158675-98461811 1189-1190 19158675 denotes 7
22396652-20890285-98461812 1203-1204 20890285 denotes 8
22396652-16039576-98461813 1504-1505 16039576 denotes 9
22396652-20144762-98461814 2201-2203 20144762 denotes 10
22396652-20805493-98461815 2206-2208 20805493 denotes 12
22396652-17942531-98461816 2381-2383 17942531 denotes 13
22396652-16625202-98461817 2453-2455 16625202 denotes 14
22396652-16714379-98461818 2459-2461 16714379 denotes 15
22396652-16789835-98461819 2538-2540 16789835 denotes 16
22396652-16153868-98461820 3119-3121 16153868 denotes 17
22396652-16127453-98461821 3124-3126 16127453 denotes 20
22396652-17392790-98461822 3359-3361 17392790 denotes 22
22396652-19484123-98461823 3375-3377 19484123 denotes 23
22396652-21147464-98461824 3381-3383 21147464 denotes 24
22396652-16306936-98461825 3505-3507 16306936 denotes 25
22396652-16306937-98461826 3511-3513 16306937 denotes 26
22396652-19479062-98461827 3526-3528 19479062 denotes 27
22396652-17991829-98461828 3667-3669 17991829 denotes 28
22396652-18467330-98461829 3678-3680 18467330 denotes 29
22396652-18636086-98461830 3684-3686 18636086 denotes 30
22396652-19996094-98461831 3701-3703 19996094 denotes 31
22396652-19881509-98461832 3916-3918 19881509 denotes 32
22396652-19893624-98461833 3933-3935 19893624 denotes 33
22396652-21167755-98461834 4183-4185 21167755 denotes 34
22396652-19635865-98461835 4196-4198 19635865 denotes 35
22396652-18711448-98461836 4211-4213 18711448 denotes 36
22396652-11009421-98461837 4648-4650 11009421 denotes 37
22396652-22099304-98461838 4653-4655 22099304 denotes 39
22396652-15334086-98461839 4664-4666 15334086 denotes 40
22396652-20185725-98461840 4680-4682 20185725 denotes 41
22396652-11009421-98461841 4854-4856 11009421 denotes 37
22396652-22019834-98461842 4990-4992 22019834 denotes 42
22396652-21841782-98461843 4995-4997 21841782 denotes 48
22396652-19643665-98461844 5302-5304 19643665 denotes 45
22396652-16765340-98461845 5676-5678 16765340 denotes 49
22396652-15661910-98461846 5681-5683 15661910 denotes 52

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T1999 3684-3686 CD denotes 30
T2150 4645-4646 CD denotes I
T2149 4636-4644 NN denotes receptor
T2148 4632-4635 NN denotes TNF
T2147 4629-4631 IN denotes as
T2146 4624-4628 JJ denotes such
T2145 4614-4623 NN denotes receptors
T2144 4605-4613 JJ denotes multiple
T2143 4602-4604 TO denotes to
T2142 4593-4601 NN denotes response
T2141 4590-4592 IN denotes in
T2140 4586-4589 NN denotes A20
T2139 4583-4585 IN denotes by
T2138 4573-4582 NN denotes signaling
T2137 4557-4572 JJ denotes proinflammatory
T2136 4554-4556 IN denotes of
T2135 4543-4553 NN denotes regulation
T2134 4534-4542 JJ denotes negative
T2133 4530-4533 DT denotes the
T2132 4527-4529 IN denotes in
T2131 4518-4526 VB denotes involved
T2130 4515-4517 VB denotes be
T2129 4512-4514 TO denotes to
T2128 4506-4511 VB denotes shown
T2127 4495-4505 RB denotes previously
T2126 4490-4494 VB denotes were
T2125 4479-4489 NN denotes mechanisms
T2124 4466-4478 JJ denotes noncatalytic
T2123 4462-4465 CC denotes and
T2122 4452-4461 JJ denotes catalytic
T2121 4447-4451 CC denotes Both
T2120 4437-4445 NN denotes activity
T2119 4430-4436 NN denotes ligase
T2118 4420-4429 NN denotes ubiquitin
T2117 4417-4419 NN denotes E3
T2116 4404-4416 JJ denotes K48-specific
T2115 4394-4403 JJ denotes dependent
T2114 4387-4393 NN denotes finger
T2113 4382-4386 NN denotes zinc
T2112 4373-4381 JJ denotes atypical
T2111 4365-4372 VB denotes harbors
T2110 4360-4364 RB denotes also
T2109 4356-4359 NN denotes A20
T2108 4354-4355 -COMMA- denotes ,
T2107 4341-4354 RB denotes Interestingly
T2106 4335-4339 NN denotes DUBs
T2105 4332-4334 IN denotes of
T2104 4325-4331 NN denotes family
T2103 4314-4324 NN denotes OTU-domain
T2102 4310-4313 DT denotes the
T2101 4307-4309 TO denotes to
T2100 4297-4306 VB denotes belonging
T2099 4290-4296 NN denotes enzyme
T2098 4272-4289 JJ denotes ubiquitin-editing
T2097 4269-4271 DT denotes an
T2096 4266-4268 VB denotes is
T2095 4262-4265 NN denotes A20
T2094 4248-4260 NN denotes transduction
T2093 4241-4247 NN denotes signal
T2092 4231-4240 JJ denotes antiviral
T2091 4223-4230 VB denotes dampens
T2090 4215-4222 RB denotes further
T2089 4213-4214 -RRB- denotes ]
T2088 4211-4213 CD denotes 36
T2087 4210-4211 -LRB- denotes [
T2086 4204-4209 NN denotes RBCK1
T2085 4200-4203 CC denotes and
T2084 4198-4199 -RRB- denotes ]
T2083 4196-4198 CD denotes 35
T2082 4195-4196 -LRB- denotes [
T2081 4188-4194 NN denotes TRIM21
T2080 4186-4187 -COMMA- denotes ,
T2079 4185-4186 -RRB- denotes ]
T2078 4183-4185 CD denotes 34
T2077 4182-4183 -LRB- denotes [
T2076 4177-4181 NN denotes RAUL
T2075 4174-4176 IN denotes as
T2074 4169-4173 JJ denotes such
T2073 4165-4168 NN denotes E3s
T2072 4162-4164 IN denotes by
T2071 4154-4161 NN denotes factors
T2070 4140-4153 NN denotes transcription
T2069 4135-4139 NN denotes IRF7
T2068 4131-4134 CC denotes and
T2067 4126-4130 NN denotes IRF3
T2066 4122-4125 DT denotes the
T2065 4119-4121 TO denotes to
T2064 4112-4118 NN denotes chains
T2063 4098-4111 NN denotes polyubiquitin
T2062 4085-4097 JJ denotes K48-specific
T2061 4082-4084 IN denotes of
T2060 4071-4081 NN denotes attachment
T2059 4067-4070 DT denotes the
T2058 4065-4066 -COMMA- denotes ,
T2057 4053-4065 RB denotes Additionally
T2056 4042-4051 NN denotes signaling
T2055 4031-4041 JJ denotes downstream
T2054 4023-4030 JJ denotes further
T2053 4012-4022 VB denotes inhibiting
T2052 4007-4011 RB denotes thus
T2051 4005-4006 -COMMA- denotes ,
T2050 3994-4005 NN denotes degradation
T2049 3985-3993 VB denotes mediated
T2048 3974-3984 NN denotes proteasome
T2047 3970-3973 IN denotes for
T2046 3964-3969 NN denotes TRAF3
T2045 3960-3963 CC denotes and
T2044 3955-3959 NN denotes MAVS
T2043 3942-3954 RB denotes respectively
T2042 3937-3941 NN denotes mark
T2041 3935-3936 -RRB- denotes ]
T2040 3933-3935 CD denotes 33
T2039 3932-3933 -LRB- denotes [
T2038 3924-3931 NN denotes TRIAD3A
T2037 3920-3923 CC denotes and
T2036 3918-3919 -RRB- denotes ]
T2035 3916-3918 CD denotes 32
T2034 3915-3916 -LRB- denotes [
T2033 3910-3914 NN denotes AIP4
T2032 3907-3909 IN denotes as
T2031 3902-3906 JJ denotes such
T2030 3900-3901 -COMMA- denotes ,
T2029 3893-3900 NN denotes ligases
T2028 3883-3892 NN denotes ubiquitin
T2027 3870-3882 JJ denotes K48-specific
T2026 3862-3869 JJ denotes various
T2025 3860-3861 -COMMA- denotes ,
T2024 3849-3860 RB denotes Furthermore
T2023 3838-3847 NN denotes molecules
T2022 3828-3837 VB denotes signaling
T2021 3820-3827 JJ denotes several
T2020 3815-3819 IN denotes from
T2019 3808-3814 NN denotes chains
T2018 3794-3807 NN denotes polyubiquitin
T2017 3783-3793 JJ denotes K63-linked
T2016 3774-3782 VB denotes removing
T2015 3761-3773 RB denotes specifically
T2014 3758-3760 IN denotes by
T2013 3748-3757 NN denotes signaling
T2012 3744-3747 NN denotes RLR
T2011 3735-3743 VB denotes regulate
T2010 3724-3734 RB denotes negatively
T2009 3721-3723 TO denotes to
T2008 3715-3720 VB denotes shown
T2007 3710-3714 VB denotes been
T2006 3705-3709 VB denotes have
T2005 3703-3704 -RRB- denotes ]
T2004 3701-3703 CD denotes 31
T2003 3700-3701 -LRB- denotes [
T2002 3692-3699 NN denotes OTUB1/2
T2001 3688-3691 CC denotes and
T2000 3686-3687 -RRB- denotes ]
T1998 3683-3684 -LRB- denotes [
T1997 3681-3682 -COMMA- denotes ,
T1996 3680-3681 -RRB- denotes ]
T1995 3678-3680 CD denotes 29
T1994 3677-3678 -LRB- denotes [
T1993 3672-3676 NN denotes CYLD
T1992 3670-3671 -COMMA- denotes ,
T1991 3669-3670 -RRB- denotes ]
T1990 3667-3669 CD denotes 28
T1989 3666-3667 -LRB- denotes [
T1988 3661-3665 NNP denotes DUBA
T1987 3658-3660 IN denotes as
T1986 3653-3657 JJ denotes such
T1985 3651-3652 -COMMA- denotes ,
T1984 3650-3651 -RRB- denotes )
T1983 3646-3650 NN denotes DUBs
T1982 3645-3646 -LRB- denotes (
T1981 3637-3644 NN denotes enzymes
T1980 3620-3636 VB denotes deubiquitinating
T1979 3618-3619 -COMMA- denotes ,
T1978 3614-3618 NN denotes hand
T1977 3608-3613 JJ denotes other
T1976 3604-3607 DT denotes the
T1975 3601-3603 IN denotes On
T1974 3588-3599 NN denotes stimulation
T1973 3582-3587 NN denotes RIG-I
T1972 3577-3581 IN denotes upon
T1971 3566-3576 NN denotes activation
T1970 3561-3565 NN denotes IRF3
T1969 3557-3560 CC denotes and
T1968 3551-3556 NN denotes NF-κB
T1967 3538-3550 RB denotes respectively
T1966 3530-3537 VB denotes mediate
T1965 3528-3529 -RRB- denotes ]
T1964 3526-3528 CD denotes 27
T1963 3525-3526 -LRB- denotes [
T1962 3519-3524 NN denotes TRAF3
T1961 3515-3518 CC denotes and
T1960 3513-3514 -RRB- denotes ]
T1959 3511-3513 CD denotes 26
T1958 3510-3511 -LRB- denotes [
T1957 3508-3509 -COMMA- denotes ,
T1956 3507-3508 -RRB- denotes ]
T1955 3505-3507 CD denotes 25
T1954 3504-3505 -LRB- denotes [
T1953 3498-3503 NN denotes TRAF6
T1952 3495-3497 IN denotes as
T1951 3490-3494 JJ denotes such
T1950 3482-3489 NN denotes ligases
T1949 3472-3481 NN denotes ubiquitin
T1948 3458-3471 VB denotes characterized
T1947 3453-3457 RB denotes well
T1946 3451-3452 -COMMA- denotes ,
T1945 3443-3451 NN denotes addition
T1944 3440-3442 IN denotes In
T1943 3428-3438 NN denotes activation
T1942 3422-3427 NN denotes RIG-I
T1941 3414-3421 VB denotes promote
T1940 3405-3413 RB denotes directly
T1939 3402-3404 TO denotes to
T1938 3396-3401 VB denotes shown
T1937 3391-3395 VB denotes been
T1936 3386-3390 VB denotes have
T1935 3384-3385 -COMMA- denotes ,
T1920 3343-3347 JJ denotes such
T1919 3341-3342 -COMMA- denotes ,
T1918 3340-3341 -RRB- denotes )
T1917 3337-3340 NN denotes E3s
T1916 3336-3337 -LRB- denotes (
T1915 3328-3335 NN denotes ligases
T1914 3318-3327 NN denotes ubiquitin
T1913 3305-3317 JJ denotes K63-specific
T1912 3302-3303 -RRB- denotes ]
T1911 3300-3302 CD denotes 21
T1910 3299-3300 -LRB- denotes [
T1909 3286-3298 NN denotes transduction
T1908 3279-3285 NN denotes signal
T1907 3270-3278 JJ denotes mediated
T1906 3264-3269 NN denotes RIG-I
T1905 3255-3263 VB denotes regulate
T1904 3244-3254 RB denotes negatively
T1903 3240-3243 CC denotes and
T1902 3229-3239 RB denotes positively
T1901 3224-3228 CC denotes both
T1900 3218-3223 WDT denotes which
T1899 3216-3217 -COMMA- denotes ,
T1898 3209-3216 NN denotes enzymes
T1897 3199-3208 VB denotes modifying
T1896 3189-3198 NN denotes ubiquitin
T1895 3181-3188 JJ denotes various
T1894 3178-3180 IN denotes of
T1893 3171-3177 NN denotes action
T1892 3167-3170 DT denotes the
T1891 3158-3166 VB denotes requires
T1890 3153-3157 NN denotes MAVS
T1889 3150-3152 IN denotes of
T1888 3139-3149 RB denotes downstream
T1887 3129-3138 VB denotes Signaling
T1886 3126-3127 -RRB- denotes ]
T1885 3124-3126 CD denotes 20
T1884 3123-3124 -LRB- denotes [
T1883 3122-3123 CD denotes –
T1882 3121-3122 -RRB- denotes ]
T1881 3119-3121 CD denotes 17
T1880 3118-3119 -LRB- denotes [
T1879 3111-3117 NN denotes domain
T1878 3097-3110 NN denotes transmembrane
T1877 3086-3096 JJ denotes C-terminal
T1876 3082-3085 PRP-DOLLAR- denotes its
T1875 3078-3081 IN denotes via
T1874 3069-3077 NN denotes membrane
T1873 3055-3068 JJ denotes mitochondrial
T1872 3049-3054 JJ denotes outer
T1871 3045-3048 DT denotes the
T1870 3042-3044 IN denotes in
T1869 3034-3041 NN denotes inserts
T1868 3030-3033 CC denotes and
T1867 3027-3029 TO denotes to
T1866 3014-3026 VB denotes translocates
T1865 3001-3013 RB denotes subsequently
T1864 2995-3000 WDT denotes which
T1863 2993-2994 -COMMA- denotes ,
T1862 2986-2993 NN denotes protein
T1861 2978-2985 NN denotes adaptor
T1860 2976-2977 -RRB- denotes )
T1859 2970-2976 NNP denotes Cardif
T1858 2968-2969 -COMMA- denotes ,
T1857 2964-2968 NN denotes VISA
T1856 2962-2963 -COMMA- denotes ,
T1855 2957-2962 NN denotes IPS-1
T1854 2950-2956 VB denotes termed
T1853 2945-2949 RB denotes also
T1852 2944-2945 -LRB- denotes (
T1851 2939-2943 NN denotes MAVS
T1850 2935-2938 DT denotes the
T1849 2932-2934 IN denotes of
T1848 2925-2931 NN denotes domain
T1847 2920-2924 NN denotes CARD
T1846 2916-2919 DT denotes the
T1845 2911-2915 IN denotes with
T1844 2901-2910 VB denotes associate
T1843 2895-2900 NN denotes RIG-I
T1842 2892-2894 IN denotes of
T1841 2884-2891 NN denotes domains
T1840 2879-2883 NN denotes CARD
T1839 2875-2878 DT denotes the
T1838 2873-2874 -COMMA- denotes ,
T1837 2866-2873 NN denotes binding
T1836 2859-2865 NN denotes ligand
T1835 2854-2858 IN denotes Upon
T1834 2845-2852 NN denotes domains
T1833 2840-2844 NN denotes CARD
T1832 2829-2839 JJ denotes N-terminal
T1831 2825-2828 CD denotes two
T1830 2821-2824 CC denotes and
T1829 2819-2820 -COMMA- denotes ,
T1828 2808-2819 NN denotes recognition
T1827 2801-2807 NN denotes ligand
T1826 2797-2800 IN denotes for
T1825 2788-2796 VB denotes required
T1824 2785-2787 VB denotes is
T1823 2779-2784 WDT denotes which
T1822 2777-2778 -COMMA- denotes ,
T1821 2771-2777 NN denotes domain
T1820 2762-2770 NN denotes helicase
T1819 2758-2761 NN denotes box
T1818 2751-2757 NN denotes DExD/H
T1817 2740-2750 JJ denotes C-terminal
T1816 2738-2739 DT denotes a
T1815 2729-2737 VB denotes contains
T1814 2723-2728 NN denotes RIG-I
T1813 2712-2721 NN denotes influenza
T1812 2709-2711 IN denotes of
T1811 2696-2708 NN denotes pathogenesis
T1810 2692-2695 DT denotes the
T1809 2689-2691 TO denotes to
T1808 2678-2688 VB denotes contribute
T1807 2675-2677 TO denotes to
T1806 2668-2674 JJ denotes likely
T1805 2665-2667 VB denotes is
T1804 2659-2664 NN denotes cells
T1803 2652-2658 JJ denotes immune
T1802 2649-2651 IN denotes by
T1801 2640-2648 VB denotes released
T1800 2630-2639 NN denotes mediators
T1799 2627-2629 IN denotes of
T1798 2619-2626 NN denotes effects
T1797 2611-2618 JJ denotes harmful
T1796 2607-2610 CC denotes and
T1795 2596-2606 JJ denotes beneficial
T1794 2592-2595 DT denotes the
T1793 2584-2591 IN denotes between
T1792 2574-2583 NN denotes imbalance
T1791 2571-2573 DT denotes an
T1790 2566-2570 IN denotes that
T1789 2557-2565 VB denotes indicate
T1788 2549-2556 NN denotes results
T1787 2543-2548 DT denotes These
T1786 2540-2541 -RRB- denotes ]
T1785 2538-2540 CD denotes 16
T1784 2537-2538 -LRB- denotes [
T1783 2527-2536 NN denotes infection
T1782 2521-2526 JJ denotes acute
T1781 2518-2520 TO denotes to
T1780 2508-2517 NN denotes advantage
T1779 2499-2507 NN denotes survival
T1778 2497-2498 DT denotes a
T1777 2492-2496 VB denotes have
T1776 2487-2491 NN denotes mice
T1775 2477-2486 JJ denotes deficient
T1774 2472-2476 NN denotes TLR3
T1773 2464-2471 IN denotes whereas
T1772 2462-2463 -COMMA- denotes ,
T1771 2461-2462 -RRB- denotes ]
T1770 2459-2461 CD denotes 15
T1769 2458-2459 -LRB- denotes [
T1768 2456-2457 -COMMA- denotes ,
T1767 2455-2456 -RRB- denotes ]
T1766 2453-2455 CD denotes 14
T1765 2452-2453 -LRB- denotes [
T1764 2448-2451 NN denotes IAV
T1763 2445-2447 TO denotes to
T1762 2433-2444 JJ denotes susceptible
T1761 2426-2432 RB denotes highly
T1760 2422-2425 VB denotes are
T1759 2417-2421 NN denotes mice
T1758 2407-2416 JJ denotes deficient
T1757 2401-2406 NN denotes RIG-I
T1756 2399-2400 -COMMA- denotes ,
T1755 2386-2399 RB denotes Interestingly
T1754 2383-2384 -RRB- denotes ]
T1753 2381-2383 CD denotes 13
T1752 2380-2381 -LRB- denotes [
T1751 2370-2379 NN denotes signaling
T1750 2361-2369 VB denotes mediated
T1749 2355-2360 NN denotes RIG-I
T1748 2352-2354 IN denotes on
T1747 2344-2351 VB denotes depends
T1746 2336-2343 RB denotes largely
T1745 2327-2335 NN denotes response
T1744 2320-2326 JJ denotes immune
T1743 2310-2319 JJ denotes antiviral
T1742 2303-2309 JJ denotes innate
T1741 2299-2302 DT denotes the
T1740 2296-2298 IN denotes of
T1739 2285-2295 NN denotes initiation
T1738 2281-2284 DT denotes the
T1737 2277-2280 CC denotes but
T1736 2275-2276 -COMMA- denotes ,
T1735 2272-2275 NN denotes IAV
T1734 2269-2271 TO denotes to
T1733 2260-2268 NN denotes response
T1732 2244-2259 JJ denotes proinflammatory
T1731 2240-2243 DT denotes the
T2477 6564-6573 NN denotes potential
T2476 6552-6563 JJ denotes therapeutic
T2475 6547-6551 VB denotes have
T2474 6541-6546 MD denotes might
T2473 6535-6540 NN denotes cells
T2472 6527-6534 JJ denotes myeloid
T2471 6524-6526 IN denotes in
T2470 6515-6523 NN denotes activity
T2469 6511-6514 NN denotes A20
T2468 6501-6510 VB denotes targeting
T2467 6498-6500 IN denotes by
T2466 6494-6497 NN denotes IAV
T2465 6491-6493 TO denotes to
T2464 6482-6490 NN denotes response
T2463 6475-6481 JJ denotes immune
T2462 6468-6474 JJ denotes innate
T2461 6464-6467 DT denotes the
T2460 6455-6463 VB denotes boosting
T2459 6450-6454 IN denotes that
T2458 6442-6449 VB denotes suggest
T2457 6434-6441 NN denotes results
T2456 6428-6433 DT denotes These
T2455 6417-6426 NN denotes clearance
T2454 6411-6416 JJ denotes viral
T2453 6402-6410 VB denotes enhanced
T2452 6398-6401 CC denotes and
T2451 6396-6397 -COMMA- denotes ,
T2450 6385-6396 NN denotes macrophages
T2449 6376-6384 JJ denotes alveolar
T2448 6372-6375 CC denotes and
T2447 6361-6371 NN denotes neutophils
T2446 6358-6360 IN denotes as
T2445 6353-6357 JJ denotes such
T2444 6347-6352 NN denotes cells
T2443 6340-6346 JJ denotes immune
T2442 6333-6339 JJ denotes innate
T2441 6330-6332 IN denotes of
T2440 6318-6329 NN denotes recruitment
T2439 6308-6317 VB denotes augmented
T2438 6306-6307 -COMMA- denotes ,
T2437 6296-6306 NN denotes production
T2436 6286-6295 NN denotes chemokine
T2435 6282-6285 CC denotes and
T2434 6273-6281 NN denotes cytokine
T2433 6263-6272 VB denotes increased
T2432 6258-6262 IN denotes with
T2431 6247-6257 VB denotes associated
T2430 6244-6246 VB denotes is
T2429 6239-6243 NN denotes mice
T2428 6228-6238 NN denotes A20myel-KO
T2427 6225-6227 IN denotes in
T2426 6221-6224 NN denotes IAV
T2425 6213-6220 IN denotes against
T2424 6202-6212 NN denotes Protection
T2423 6196-6200 NN denotes mice
T2422 6191-6195 NN denotes type
T2421 6186-6190 JJ denotes wild
T2420 6183-6185 TO denotes to
T2419 6174-6182 VB denotes compared
T2418 6164-6173 NN denotes infection
T2417 6159-6163 NN denotes lung
T2416 6155-6158 NN denotes IAV
T2415 6152-6154 TO denotes to
T2414 6143-6151 NN denotes response
T2413 6140-6142 IN denotes in
T2412 6130-6139 NN denotes morbidity
T2411 6122-6129 VB denotes reduced
T2410 6118-6121 CC denotes and
T2409 6109-6117 NN denotes survival
T2408 6100-6108 VB denotes enhanced
T2407 6095-6099 VB denotes show
T2406 6090-6094 NN denotes mice
T2405 6079-6089 NN denotes A20myel-KO
T2404 6077-6078 -COMMA- denotes ,
T2403 6064-6077 RB denotes Interestingly
T2402 6051-6062 NN denotes macrophages
T2401 6048-6050 IN denotes in
T2400 6038-6047 NN denotes signaling
T2399 6028-6037 JJ denotes antiviral
T2398 6024-6027 CC denotes and
T2397 6008-6023 JJ denotes proinflammatory
T2396 5996-6007 JJ denotes IAV-induced
T2395 5993-5995 IN denotes of
T2394 5983-5992 NN denotes regulator
T2393 5974-5982 JJ denotes negative
T2340 5686-5693 RB denotes However
T2339 5683-5684 -RRB- denotes ]
T2338 5681-5683 CD denotes 52
T2337 5680-5681 -LRB- denotes [
T2336 5679-5680 CD denotes –
T2335 5678-5679 -RRB- denotes ]
T2334 5676-5678 CD denotes 49
T2333 5675-5676 -LRB- denotes [
T2332 5669-5674 NN denotes IRF-3
T2331 5665-5668 CC denotes and
T2330 5659-5664 NN denotes NF-κB
T2329 5656-5658 TO denotes to
T2328 5646-5655 NN denotes signaling
T2327 5633-5645 JJ denotes TLR3-induced
T2326 5629-5632 CC denotes and
T2325 5622-5628 NN denotes RIG-I-
T2324 5613-5621 VB denotes regulate
T2323 5609-5612 MD denotes may
T2322 5605-5608 NN denotes A20
T2321 5600-5604 IN denotes that
T2320 5589-5599 VB denotes indicating
T2319 5587-5588 -COMMA- denotes ,
T2318 5582-5587 NN denotes lines
T2317 5577-5581 NN denotes cell
T2316 5568-5576 JJ denotes specific
T2315 5565-5567 IN denotes in
T2314 5555-5564 NN denotes silencing
T2313 5552-5554 CC denotes or
T2312 5537-5551 NN denotes overexpression
T2311 5531-5536 VB denotes using
T2310 5523-5530 NN denotes studies
T2309 5517-5522 FW denotes vitro
T2308 5514-5516 FW denotes in
T2307 5511-5513 IN denotes of
T2306 5504-5510 NN denotes number
T2305 5502-5503 DT denotes a
T2304 5499-5501 TO denotes to
T2303 5491-5498 VB denotes limited
T2302 5487-5490 CC denotes and
T2301 5477-5486 VB denotes described
T2300 5472-5476 RB denotes well
T2299 5467-5471 RB denotes less
T2298 5464-5466 VB denotes is
T2297 5454-5463 NN denotes responses
T2296 5447-5453 JJ denotes immune
T2295 5437-5446 JJ denotes antiviral
T2294 5434-5436 IN denotes of
T2293 5423-5433 NN denotes regulation
T2292 5419-5422 DT denotes the
T2291 5416-5418 IN denotes in
T2290 5412-5415 NN denotes A20
T2289 5409-5411 IN denotes of
T2288 5404-5408 NN denotes role
T2287 5400-5403 DT denotes the
T2286 5398-5399 -COMMA- denotes ,
T2285 5389-5398 NN denotes responses
T2284 5373-5388 JJ denotes proinflammatory
T2283 5370-5372 IN denotes of
T2282 5359-5369 NN denotes regulation
T2281 5355-5358 DT denotes the
T2280 5352-5354 IN denotes in
T2279 5343-5351 NN denotes function
T2278 5331-5342 VB denotes established
T2277 5326-5330 RB denotes well
T2276 5322-5325 PRP-DOLLAR- denotes its
T2275 5319-5321 TO denotes to
T2274 5310-5318 NN denotes contrast
T2273 5307-5309 IN denotes In
T2272 5304-5305 -RRB- denotes ]
T2271 5302-5304 CD denotes 45
T2270 5301-5302 -LRB- denotes [
T2269 5288-5300 NN denotes inflammation
T2268 5280-5287 JJ denotes chronic
T2267 5276-5279 CC denotes and
T2266 5267-5275 NN denotes diseases
T2265 5256-5266 JJ denotes autoimmune
T2264 5248-5255 JJ denotes several
T2263 5243-5247 IN denotes with
T2262 5232-5242 VB denotes associated
T2261 5228-5231 VB denotes are
T2260 5223-5227 WDT denotes that
T2259 5217-5222 NN denotes locus
T2258 5213-5216 NN denotes A20
T2257 5209-5212 DT denotes the
T2256 5206-5208 IN denotes in
T2255 5192-5205 NN denotes polymorphisms
T2254 5189-5191 IN denotes of
T2253 5174-5188 NN denotes identification
T2252 5170-5173 DT denotes the
T2251 5162-5169 IN denotes through
T2250 5150-5161 VB denotes illustrated
T2249 5145-5149 VB denotes been
T2248 5136-5144 RB denotes recently
T2247 5132-5135 VB denotes has
T2246 5124-5131 NN denotes disease
T2245 5118-5123 JJ denotes human
T2244 5114-5117 IN denotes for
T2243 5105-5113 NN denotes findings
T2242 5099-5104 DT denotes these
T2241 5096-5098 IN denotes of
T2240 5086-5095 NN denotes relevance
T2239 5082-5085 DT denotes The
T2238 5072-5080 NN denotes response
T2237 5059-5071 JJ denotes inflammatory
T2236 5055-5058 DT denotes the
T2235 5052-5054 IN denotes on
T2234 5046-5051 NN denotes brake
T2233 5036-5045 JJ denotes important
T2232 5033-5035 DT denotes an
T2231 5030-5032 VB denotes is
T2230 5026-5029 NN denotes A20
T2229 5021-5025 IN denotes that
T2228 5008-5020 VB denotes illustrating
T2227 5000-5007 RB denotes further
T2226 4998-4999 -COMMA- denotes ,
T2225 4997-4998 -RRB- denotes ]
T2224 4995-4997 CD denotes 48
T2223 4994-4995 -LRB- denotes [
T2222 4993-4994 CD denotes –
T2221 4992-4993 -RRB- denotes ]
T2220 4990-4992 CD denotes 42
T2219 4989-4990 -LRB- denotes [
T2218 4976-4988 NN denotes inflammation
T2217 4968-4975 JJ denotes chronic
T2216 4964-4967 CC denotes and
T2215 4951-4963 NN denotes autoimmunity
T2214 4946-4950 IN denotes with
T2213 4935-4945 VB denotes associated
T2212 4932-4934 VB denotes be
T2211 4929-4931 TO denotes to
T2210 4923-4928 VB denotes shown
T2209 4919-4922 VB denotes was
T2208 4913-4918 NN denotes types
T2207 4908-4912 NN denotes cell
T2206 4899-4907 JJ denotes specific
T2205 4896-4898 IN denotes in
T2204 4892-4895 NN denotes A20
T2203 4889-4891 IN denotes of
T2202 4879-4888 NN denotes targeting
T2201 4874-4878 NN denotes gene
T2200 4872-4873 -COMMA- denotes ,
T2199 4864-4872 RB denotes recently
T2198 4859-4863 RB denotes More
T2197 4856-4857 -RRB- denotes ]
T2196 4854-4856 CD denotes 37
T2195 4853-4854 -LRB- denotes [
T2194 4844-4852 NN denotes cachexia
T2193 4840-4843 CC denotes and
T2192 4827-4839 NN denotes inflammation
T2191 4815-4826 JJ denotes multi-organ
T2190 4808-4814 JJ denotes severe
T2189 4805-4807 TO denotes to
T2188 4801-4804 JJ denotes due
T2187 4795-4800 NN denotes birth
T2186 4789-4794 IN denotes after
T2185 4783-4788 RB denotes early
T2184 4779-4782 VB denotes die
T2183 4774-4778 NN denotes mice
T2182 4764-4773 JJ denotes deficient
T2181 4760-4763 NN denotes A20
T2180 4755-4759 IN denotes that
T2179 4750-4754 NN denotes fact
T2178 4746-4749 DT denotes the
T2177 4743-4745 IN denotes by
T2176 4730-4742 VB denotes demonstrated
T2175 4722-4729 RB denotes clearly
T2174 4719-4721 VB denotes is
T2173 4715-4718 NN denotes A20
T2172 4712-4714 IN denotes of
T2171 4707-4711 NN denotes role
T2170 4689-4706 JJ denotes anti-inflammatory
T2169 4685-4688 DT denotes The
T2168 4682-4683 -RRB- denotes ]
T2167 4680-4682 CD denotes 41
T2166 4679-4680 -LRB- denotes [
T2165 4673-4678 NN denotes IL-1R
T2164 4669-4672 CC denotes and
T2163 4667-4668 -COMMA- denotes ,
T2162 4666-4667 -RRB- denotes ]
T2161 4664-4666 CD denotes 40
T2160 4663-4664 -LRB- denotes [
T2159 4658-4662 NN denotes TLR4
T2158 4656-4657 -COMMA- denotes ,
T2157 4655-4656 -RRB- denotes ]
T2156 4653-4655 CD denotes 39
T2155 4652-4653 -LRB- denotes [
T2154 4651-4652 CD denotes –
T2153 4650-4651 -RRB- denotes ]
T2152 4648-4650 CD denotes 37
T2151 4647-4648 -LRB- denotes [
T1730 2237-2239 TO denotes to
T1729 2226-2236 VB denotes contribute
T1728 2216-2225 NN denotes receptors
T1727 2211-2215 DT denotes Both
T1726 2208-2209 -RRB- denotes ]
T1725 2206-2208 CD denotes 12
T1724 2205-2206 -LRB- denotes [
T1723 2204-2205 CD denotes –
T1722 2203-2204 -RRB- denotes ]
T1721 2201-2203 CD denotes 10
T1720 2200-2201 -LRB- denotes [
T1719 2190-2199 NN denotes infection
T1718 2186-2189 NN denotes IAV
T1717 2183-2185 IN denotes of
T1716 2175-2182 NN denotes sensors
T1715 2172-2174 IN denotes as
T1714 2161-2171 VB denotes implicated
T1713 2156-2160 VB denotes been
T1712 2151-2155 VB denotes have
T1711 2145-2150 NN denotes RIG-I
T1710 2141-2144 CC denotes and
T1709 2136-2140 NN denotes TLR3
T1708 2123-2134 NN denotes replication
T1707 2117-2122 JJ denotes viral
T1706 2114-2116 IN denotes of
T1705 2101-2113 NN denotes intermediate
T1537 1129-1130 CD denotes 4
T1536 1128-1129 -LRB- denotes [
T1535 1124-1127 NNP denotes DAI
T1534 1122-1123 -COMMA- denotes ,
T1533 1118-1122 NN denotes TLR9
T1532 1110-1117 VB denotes include
T1531 1102-1109 NN denotes viruses
T1530 1098-1101 NN denotes DNA
T1529 1095-1097 TO denotes to
T1528 1085-1094 NN denotes responses
T1527 1078-1084 JJ denotes immune
T1526 1068-1077 JJ denotes antiviral
T1525 1060-1067 VB denotes mediate
T1524 1055-1059 WDT denotes that
T1523 1047-1054 NN denotes sensors
T1522 1043-1046 NN denotes DNA
T1521 1029-1042 JJ denotes Intracellular
T1520 1026-1027 -RRB- denotes )
T1519 1022-1026 NN denotes MDA5
T1518 1020-1021 -COMMA- denotes ,
T1517 1015-1020 NN denotes RIG-I
T1516 1013-1014 -COMMA- denotes ,
T1515 1009-1013 NN denotes TLR3
T1514 1008-1009 -LRB- denotes (
T1513 1004-1007 NN denotes RNA
T1512 995-1003 JJ denotes stranded
T1511 988-994 JJ denotes double
T1510 985-987 CC denotes or
T1509 983-984 -RRB- denotes )
T1508 979-983 NN denotes Nod2
T1507 977-978 -COMMA- denotes ,
T1506 973-977 NN denotes TLR8
T1505 971-972 -COMMA- denotes ,
T1504 967-971 NN denotes TLR7
T1503 966-967 -LRB- denotes (
T1502 957-965 JJ denotes stranded
T1501 950-956 JJ denotes single
T1500 944-949 JJ denotes viral
T1499 941-943 IN denotes of
T1498 932-940 NN denotes presence
T1497 928-931 DT denotes the
T1496 921-927 VB denotes detect
T1495 919-920 -RRB- denotes )
T1494 915-919 NN denotes NLRs
T1493 914-915 -LRB- denotes (
T1492 904-913 NN denotes receptors
T1491 895-903 JJ denotes Nod-like
T1490 892-894 CC denotes or
T1489 890-891 -RRB- denotes )
T1488 886-890 NN denotes RLRs
T1487 885-886 -LRB- denotes (
T1486 875-884 NN denotes receptors
T1485 864-874 JJ denotes RIG-I-like
T1484 855-863 NN denotes helicase
T1483 851-854 NN denotes RNA
T1482 839-850 JJ denotes cytoplasmic
T1481 835-838 CC denotes and
T1480 833-834 -RRB- denotes )
T1479 829-833 NN denotes TLRs
T1478 828-829 -LRB- denotes (
T1477 818-827 NN denotes receptors
T1476 808-817 JJ denotes Toll-like
T1475 798-807 JJ denotes Endosomal
T1474 795-796 -RRB- denotes ]
T1473 794-795 CD denotes 3
T1472 793-794 -LRB- denotes [
T1471 788-792 NN denotes PRRs
T1470 774-787 JJ denotes intracellular
T1469 765-773 JJ denotes specific
T1468 762-764 IN denotes by
T1467 755-761 VB denotes sensed
T1466 752-754 VB denotes be
T1465 748-751 MD denotes can
T1464 746-747 -COMMA- denotes ,
T1463 738-746 NN denotes products
T1462 724-737 NN denotes transcription
T1461 718-723 JJ denotes viral
T1460 714-717 CC denotes and
T1459 700-713 NN denotes intermediates
T1458 688-699 NN denotes replication
T1457 682-687 JJ denotes viral
T1456 680-681 -COMMA- denotes ,
T1455 677-680 NN denotes DNA
T1454 673-676 CC denotes and
T1453 669-672 NN denotes RNA
T1452 663-668 JJ denotes viral
T1451 660-662 IN denotes as
T1450 655-659 JJ denotes such
T1449 653-654 -COMMA- denotes ,
T1448 648-653 NN denotes acids
T1447 640-647 JJ denotes nucleic
T1446 634-639 JJ denotes viral
T1445 631-633 IN denotes of
T1444 622-630 NN denotes presence
T1443 618-621 DT denotes The
T1442 615-616 -RRB- denotes ]
T1441 614-615 CD denotes 2
T1440 613-614 -LRB- denotes [
T1439 611-612 -COMMA- denotes ,
T1438 610-611 -RRB- denotes ]
T1437 609-610 CD denotes 1
T1436 608-609 -LRB- denotes [
T1435 603-607 NN denotes IRF7
T1434 599-602 CC denotes and
T1433 594-598 NN denotes IRF3
T1432 592-593 -COMMA- denotes ,
T1431 588-592 NN denotes AP-1
T1430 586-587 -COMMA- denotes ,
T1429 581-586 NN denotes NF-κB
T1428 578-580 IN denotes as
T1427 573-577 JJ denotes such
T1426 565-572 NN denotes factors
T1425 551-564 NN denotes transcription
T1424 543-550 JJ denotes various
T1423 535-542 VB denotes control
T1422 530-534 WDT denotes that
T1421 521-529 NN denotes pathways
T1420 511-520 NN denotes signaling
T1419 500-510 JJ denotes downstream
T1418 497-499 IN denotes of
T1417 486-496 NN denotes activation
T1416 478-485 IN denotes through
T1415 476-477 -RRB- denotes )
T1414 471-476 NN denotes IFN-β
T1413 467-470 CC denotes and
T1412 465-466 -RRB- denotes )
T1411 460-465 NN denotes IFN-α
T1410 459-460 -LRB- denotes (
T1409 446-458 NN denotes interferon-α
T1408 445-446 -LRB- denotes (
T1407 433-444 NN denotes interferons
T1406 431-432 CD denotes I
T1405 426-430 NN denotes type
T1404 422-425 CC denotes and
T1403 420-421 -RRB- denotes )
T1402 416-420 NN denotes IL-1
T1401 412-415 CC denotes and
T1400 407-411 NN denotes IL-6
T1399 405-406 -COMMA- denotes ,
T1398 402-405 NN denotes TNF
T1397 397-401 FW denotes e.g.
T1396 396-397 -LRB- denotes (
T1395 386-395 NN denotes cytokines
T1394 370-385 JJ denotes proinflammatory
T1393 365-369 NN denotes host
T1392 362-364 IN denotes of
T1391 351-361 NN denotes production
T1390 347-350 DT denotes the
T1389 339-346 VB denotes induces
T1388 334-338 NN denotes PRRs
T1387 331-333 IN denotes of
T1386 320-330 NN denotes Triggering
T1385 310-318 NN denotes pathogen
T1384 301-309 VB denotes invading
T1383 297-300 DT denotes the
T1382 294-296 IN denotes of
T1381 283-293 NN denotes structures
T1380 273-282 JJ denotes molecular
T1379 263-272 VB denotes conserved
T1378 256-262 VB denotes detect
T1377 250-255 WDT denotes which
T1376 248-249 -COMMA- denotes ,
T1375 247-248 -RRB- denotes )
T1374 244-247 NN denotes PRR
T1373 243-244 -LRB- denotes (
T1372 233-242 NN denotes receptors
T1371 221-232 NN denotes recognition
T1370 213-220 NN denotes pattern
T1369 201-212 VB denotes specialized
T1368 198-200 IN denotes of
T1367 191-197 NN denotes action
T1366 187-190 DT denotes the
T1365 178-186 VB denotes involves
T1364 169-177 NN denotes response
T1363 162-168 JJ denotes immune
T1362 152-161 JJ denotes antiviral
T1361 145-151 JJ denotes innate
T1360 134-144 JJ denotes protective
T1359 132-133 DT denotes a
T1358 129-131 IN denotes of
T1357 118-128 NN denotes initiation
T1356 114-117 DT denotes The
T1355 101-112 NN denotes replication
T1354 95-100 PRP-DOLLAR- denotes their
T1353 91-94 IN denotes for
T1352 86-90 NN denotes cell
T1351 81-85 NN denotes host
T1350 77-80 DT denotes the
T1349 74-76 IN denotes on
T1348 67-73 VB denotes depend
T2392 5966-5973 JJ denotes crucial
T2391 5964-5965 DT denotes a
T2390 5961-5963 VB denotes is
T2389 5957-5960 NN denotes A20
T2388 5952-5956 IN denotes that
T2387 5943-5951 NN denotes evidence
T2386 5935-5942 VB denotes provide
T2385 5930-5934 RB denotes here
T2384 5927-5929 PRP denotes we
T2383 5925-5926 -COMMA- denotes ,
T2382 5921-5925 NN denotes mice
T2381 5915-5920 DT denotes these
T2380 5912-5914 IN denotes of
T2379 5904-5911 VB denotes derived
T2378 5898-5903 NN denotes cells
T2377 5890-5897 JJ denotes primary
T2376 5886-5889 CC denotes and
T2375 5882-5885 NN denotes lab
T2374 5878-5881 PRP-DOLLAR- denotes our
T2373 5875-5877 IN denotes in
T2372 5865-5874 VB denotes generated
T2371 5856-5864 RB denotes recently
T2370 5851-5855 VB denotes were
T2369 5846-5850 WDT denotes that
T2368 5844-5845 -RRB- denotes )
T2367 5834-5844 NN denotes A20myel-KO
T2366 5833-5834 -LRB- denotes (
T2365 5828-5832 NN denotes mice
T2364 5819-5827 NN denotes knockout
T2363 5815-5818 NN denotes A20
T2362 5806-5814 JJ denotes specific
T2361 5801-5805 NN denotes cell
T2360 5793-5800 JJ denotes myeloid
T2359 5787-5792 VB denotes Using
T2358 5776-5785 VB denotes clarified
T2357 5773-5775 VB denotes be
T2356 5770-5772 TO denotes to
T2355 5762-5769 VB denotes remains
T2354 5752-5761 NN denotes infection
T2353 5746-5751 JJ denotes viral
T2352 5743-5745 TO denotes to
T2351 5734-5742 NN denotes response
T2350 5730-5733 DT denotes the
T2349 5727-5729 IN denotes in
T2348 5723-5726 NN denotes A20
T2347 5720-5722 IN denotes of
T2346 5715-5719 NN denotes role
T2345 5710-5714 FW denotes vivo
T2344 5707-5709 FW denotes in
T2343 5699-5706 JJ denotes precise
T2342 5695-5698 DT denotes the
T2341 5693-5694 -COMMA- denotes ,
T1934 3383-3384 -RRB- denotes ]
T1933 3381-3383 CD denotes 24
T1932 3380-3381 -LRB- denotes [
T1931 3378-3379 -COMMA- denotes ,
T1930 3377-3378 -RRB- denotes ]
T1929 3375-3377 CD denotes 23
T1928 3374-3375 -LRB- denotes [
T1927 3367-3373 NNP denotes Riplet
T1926 3363-3366 CC denotes and
T1925 3361-3362 -RRB- denotes ]
T1924 3359-3361 CD denotes 22
T1923 3358-3359 -LRB- denotes [
T1922 3351-3357 NN denotes TRIM25
T1921 3348-3350 IN denotes as
T1347 61-66 WDT denotes which
T1346 51-60 NN denotes pathogens
T1345 43-50 JJ denotes diverse
T1344 36-42 RB denotes highly
T1343 33-35 IN denotes of
T1342 27-32 NN denotes class
T1341 25-26 DT denotes a
T1340 21-24 VB denotes are
T1339 13-20 NN denotes Viruses
T1704 2098-2100 DT denotes an
T1703 2092-2097 VB denotes being
T1702 2085-2091 JJ denotes latter
T1701 2081-2084 DT denotes the
T1700 2079-2080 -COMMA- denotes ,
T1699 2076-2079 NN denotes RNA
T1698 2067-2075 JJ denotes stranded
T1697 2060-2066 JJ denotes double
T1696 2056-2059 CC denotes and
T1695 2052-2055 NN denotes RNA
T1694 2044-2051 JJ denotes genomic
T1693 2028-2043 JJ denotes single-stranded
T1692 2025-2027 IN denotes of
T1691 2020-2024 NN denotes cell
T1690 2015-2019 NN denotes host
T1689 2011-2014 DT denotes the
T1688 2008-2010 IN denotes in
T1687 1999-2007 NN denotes exposure
T1686 1995-1998 DT denotes the
T1685 1992-1994 TO denotes to
T1684 1986-1991 VB denotes leads
T1683 1976-1985 NN denotes infection
T1682 1972-1975 NN denotes IAV
T1681 1962-1970 JJ denotes critical
T1680 1959-1961 VB denotes is
T1679 1949-1958 NN denotes responses
T1678 1942-1948 JJ denotes immune
T1677 1930-1941 JJ denotes IAV-induced
T1676 1921-1929 VB denotes regulate
T1675 1916-1920 WDT denotes that
T1674 1905-1915 NN denotes mechanisms
T1673 1901-1904 DT denotes the
T1672 1898-1900 IN denotes of
T1671 1884-1897 NN denotes understanding
T1670 1882-1883 -COMMA- denotes ,
T1669 1875-1882 NN denotes context
T1668 1870-1874 DT denotes this
T1667 1867-1869 IN denotes In
T1666 1855-1865 NN denotes strategies
T1665 1845-1854 JJ denotes antiviral
T1664 1839-1844 JJ denotes novel
T1663 1828-1838 VB denotes developing
T1662 1825-1827 IN denotes of
T1661 1814-1824 NN denotes importance
T1660 1810-1813 DT denotes the
T1659 1798-1809 VB denotes underscores
T1658 1788-1797 NN denotes potential
T1657 1779-1787 JJ denotes pandemic
T1656 1774-1778 IN denotes with
T1655 1766-1773 NN denotes viruses
T1654 1756-1765 NN denotes influenza
T1653 1753-1755 IN denotes of
T1652 1745-1752 NN denotes strains
T1651 1730-1744 JJ denotes drug-resistant
T1650 1727-1729 IN denotes of
T1649 1717-1726 NN denotes Emergence
T1648 1707-1715 NN denotes response
T1647 1694-1706 JJ denotes inflammatory
T1646 1689-1693 NN denotes host
T1645 1679-1688 JJ denotes excessive
T1644 1676-1678 DT denotes an
T1643 1673-1675 TO denotes to
T1642 1669-1672 IN denotes due
T1641 1666-1668 VB denotes be
T1640 1663-1665 TO denotes to
T1639 1654-1662 VB denotes believed
T1638 1644-1653 RB denotes generally
T1637 1641-1643 VB denotes is
T1636 1635-1640 WDT denotes which
T1635 1633-1634 -COMMA- denotes ,
T1634 1624-1633 NN denotes mortality
T1633 1611-1623 JJ denotes considerable
T1632 1604-1610 VB denotes causes
T1631 1599-1603 WDT denotes that
T1630 1591-1598 NN denotes disease
T1629 1579-1590 JJ denotes respiratory
T1628 1573-1578 JJ denotes acute
T1627 1562-1572 JJ denotes contagious
T1626 1560-1561 DT denotes a
T1625 1557-1559 IN denotes of
T1624 1551-1556 NN denotes agent
T1623 1539-1550 JJ denotes etiological
T1622 1535-1538 DT denotes the
T1621 1532-1534 VB denotes is
T1620 1530-1531 -RRB- denotes )
T1619 1527-1530 NN denotes IAV
T1618 1526-1527 -LRB- denotes (
T1617 1520-1525 NN denotes virus
T1616 1518-1519 NN denotes A
T1615 1508-1517 NN denotes Influenza
T1614 1505-1506 -RRB- denotes ]
T1613 1504-1505 CD denotes 9
T1612 1503-1504 -LRB- denotes [
T1611 1494-1502 NN denotes proteins
T1610 1484-1493 JJ denotes antiviral
T1609 1481-1483 IN denotes of
T1608 1470-1480 NN denotes production
T1607 1466-1469 DT denotes the
T1606 1462-1465 IN denotes for
T1605 1454-1461 NN denotes sensors
T1604 1450-1453 NN denotes DNA
T1603 1446-1449 CC denotes and
T1602 1442-1445 NN denotes RNA
T1601 1432-1441 JJ denotes cytosolic
T1600 1428-1431 DT denotes the
T1599 1425-1427 IN denotes on
T1598 1418-1424 VB denotes depend
T1597 1416-1417 -COMMA- denotes ,
T1596 1405-1416 NN denotes fibroblasts
T1595 1401-1404 CC denotes and
T1594 1389-1400 NN denotes macrophages
T1593 1387-1388 -COMMA- denotes ,
T1592 1386-1387 -RRB- denotes )
T1591 1383-1386 NN denotes cDC
T1590 1382-1383 -LRB- denotes (
T1589 1379-1381 NN denotes DC
T1588 1366-1378 JJ denotes conventional
T1587 1356-1365 VB denotes including
T1586 1354-1355 -COMMA- denotes ,
T1585 1349-1354 NN denotes types
T1584 1344-1348 NN denotes cell
T1583 1338-1343 JJ denotes other
T1582 1333-1337 JJ denotes most
T1581 1327-1332 IN denotes while
T1580 1325-1326 -COMMA- denotes ,
T1579 1324-1325 -RRB- denotes )
T1578 1321-1324 NN denotes pDC
T1577 1320-1321 -LRB- denotes (
T1576 1314-1319 NN denotes cells
T1575 1304-1313 JJ denotes dendritic
T1574 1291-1303 JJ denotes plasmacytoid
T1573 1281-1290 VB denotes producing
T1572 1277-1280 NN denotes IFN
T1571 1275-1276 CD denotes I
T1570 1270-1274 NN denotes type
T1569 1258-1269 VB denotes specialized
T1568 1255-1257 TO denotes to
T1567 1244-1254 JJ denotes restricted
T1566 1240-1243 VB denotes are
T1565 1230-1239 NN denotes responses
T1564 1220-1229 JJ denotes antiviral
T1563 1211-1219 VB denotes mediated
T1562 1207-1210 NN denotes TLR
T1561 1204-1205 -RRB- denotes ]
T1560 1203-1204 CD denotes 8
T1559 1202-1203 -LRB- denotes [
T1558 1196-1201 NN denotes IFI16
T1557 1192-1195 CC denotes and
T1556 1190-1191 -RRB- denotes ]
T1555 1189-1190 CD denotes 7
T1554 1188-1189 -LRB- denotes [
T1553 1186-1187 -COMMA- denotes ,
T1552 1185-1186 -RRB- denotes ]
T1551 1184-1185 CD denotes 6
T1550 1183-1184 -LRB- denotes [
T1549 1181-1182 -COMMA- denotes ,
T1548 1180-1181 -RRB- denotes ]
T1547 1179-1180 CD denotes 5
T1546 1178-1179 -LRB- denotes [
T1545 1173-1177 NN denotes AIM2
T1544 1164-1172 NN denotes proteins
T1543 1153-1163 VB denotes containing
T1542 1146-1152 NN denotes domain
T1541 1140-1145 NN denotes PYHIN
T1540 1136-1139 DT denotes the
T1539 1132-1135 CC denotes and
T1538 1130-1131 -RRB- denotes ]
R609 T1339 T1340 arg1Of Viruses,are
R610 T1342 T1340 arg2Of class,are
R611 T1342 T1341 arg1Of class,a
R612 T1342 T1343 arg1Of class,of
R613 T1345 T1344 arg1Of diverse,highly
R614 T1346 T1343 arg2Of pathogens,of
R615 T1346 T1345 arg1Of pathogens,diverse
R616 T1346 T1347 arg1Of pathogens,which
R617 T1346 T1348 arg1Of pathogens,depend
R618 T1348 T1349 arg1Of depend,on
R619 T1352 T1349 arg2Of cell,on
R620 T1352 T1350 arg1Of cell,the
R621 T1352 T1351 arg1Of cell,host
R622 T1352 T1353 arg1Of cell,for
R623 T1355 T1353 arg2Of replication,for
R624 T1355 T1354 arg1Of replication,their
R625 T1357 T1356 arg1Of initiation,The
R626 T1357 T1358 arg1Of initiation,of
R627 T1357 T1365 arg1Of initiation,involves
R628 T1364 T1358 arg2Of response,of
R629 T1364 T1359 arg1Of response,a
R630 T1364 T1360 arg1Of response,protective
R631 T1364 T1361 arg1Of response,innate
R632 T1364 T1362 arg1Of response,antiviral
R633 T1364 T1363 arg1Of response,immune
R634 T1367 T1365 arg2Of action,involves
R635 T1367 T1366 arg1Of action,the
R636 T1367 T1368 arg1Of action,of
R637 T1372 T1368 arg2Of receptors,of
R638 T1372 T1369 arg2Of receptors,specialized
R639 T1372 T1370 arg1Of receptors,pattern
R640 T1372 T1371 arg1Of receptors,recognition
R641 T1372 T1373 arg1Of receptors,(
R642 T1372 T1376 arg1Of receptors,","
R643 T1372 T1377 arg1Of receptors,which
R644 T1372 T1378 arg1Of receptors,detect
R645 T1374 T1373 arg2Of PRR,(
R646 T1375 T1373 arg3Of ),(
R647 T1381 T1378 arg2Of structures,detect
R648 T1381 T1379 arg2Of structures,conserved
R649 T1381 T1380 arg1Of structures,molecular
R650 T1381 T1382 arg1Of structures,of
R651 T1385 T1382 arg2Of pathogen,of
R652 T1385 T1383 arg1Of pathogen,the
R653 T1385 T1384 arg1Of pathogen,invading
R654 T1386 T1387 arg1Of Triggering,of
R655 T1386 T1389 arg1Of Triggering,induces
R656 T1388 T1387 arg2Of PRRs,of
R657 T1389 T1416 arg1Of induces,through
R658 T1391 T1389 arg2Of production,induces
R659 T1391 T1390 arg1Of production,the
R660 T1391 T1392 arg1Of production,of
R661 T1395 T1393 arg1Of cytokines,host
R662 T1395 T1394 arg1Of cytokines,proinflammatory
R663 T1395 T1396 arg1Of cytokines,(
R664 T1395 T1404 arg1Of cytokines,and
R665 T1398 T1399 arg1Of TNF,","
R666 T1399 T1401 arg1Of ",",and
R667 T1400 T1399 arg2Of IL-6,","
R668 T1401 T1396 arg2Of and,(
R669 T1401 T1397 arg1Of and,e.g.
R670 T1402 T1401 arg2Of IL-1,and
R671 T1403 T1396 arg3Of ),(
R672 T1404 T1392 arg2Of and,of
R673 T1407 T1404 arg2Of interferons,and
R674 T1407 T1405 arg1Of interferons,type
R675 T1407 T1406 arg1Of interferons,I
R676 T1407 T1408 arg1Of interferons,(
R677 T1409 T1410 arg1Of interferon-α,(
R678 T1409 T1413 arg1Of interferon-α,and
R679 T1411 T1410 arg2Of IFN-α,(
R680 T1412 T1410 arg3Of ),(
R681 T1413 T1408 arg2Of and,(
R682 T1414 T1413 arg2Of IFN-β,and
R683 T1415 T1408 arg3Of ),(
R684 T1417 T1416 arg2Of activation,through
R685 T1417 T1418 arg1Of activation,of
R686 T1421 T1418 arg2Of pathways,of
R687 T1421 T1419 arg1Of pathways,downstream
R688 T1421 T1420 arg1Of pathways,signaling
R689 T1421 T1422 arg1Of pathways,that
R690 T1421 T1423 arg1Of pathways,control
R691 T1423 T1439 arg1Of control,","
R692 T1423 T1440 arg1Of control,[
R693 T1426 T1423 arg2Of factors,control
R694 T1426 T1424 arg1Of factors,various
R695 T1426 T1425 arg1Of factors,transcription
R696 T1426 T1428 arg1Of factors,as
R697 T1428 T1427 arg1Of as,such
R698 T1429 T1430 arg1Of NF-κB,","
R699 T1430 T1432 arg1Of ",",","
R700 T1431 T1430 arg2Of AP-1,","
R701 T1432 T1434 arg1Of ",",and
R702 T1433 T1432 arg2Of IRF3,","
R703 T1434 T1428 arg2Of and,as
R704 T1435 T1434 arg2Of IRF7,and
R705 T1435 T1436 arg1Of IRF7,[
R706 T1437 T1436 arg2Of 1,[
R707 T1438 T1436 arg3Of ],[
R708 T1441 T1440 arg2Of 2,[
R709 T1442 T1440 arg3Of ],[
R710 T1444 T1443 arg1Of presence,The
R711 T1444 T1445 arg1Of presence,of
R712 T1444 T1465 arg1Of presence,can
R713 T1444 T1466 arg1Of presence,be
R714 T1444 T1467 arg2Of presence,sensed
R715 T1448 T1445 arg2Of acids,of
R716 T1448 T1446 arg1Of acids,viral
R717 T1448 T1447 arg1Of acids,nucleic
R718 T1448 T1449 arg1Of acids,","
R719 T1448 T1451 arg1Of acids,as
R720 T1451 T1450 arg1Of as,such
R721 T1453 T1452 arg1Of RNA,viral
R722 T1453 T1454 arg1Of RNA,and
R723 T1454 T1456 arg1Of and,","
R724 T1455 T1454 arg2Of DNA,and
R725 T1456 T1460 arg1Of ",",and
R726 T1459 T1456 arg2Of intermediates,","
R727 T1459 T1457 arg1Of intermediates,viral
R728 T1459 T1458 arg1Of intermediates,replication
R729 T1460 T1451 arg2Of and,as
R730 T1463 T1460 arg2Of products,and
R731 T1463 T1461 arg1Of products,viral
R732 T1463 T1462 arg1Of products,transcription
R733 T1467 T1464 arg1Of sensed,","
R734 T1467 T1465 arg2Of sensed,can
R735 T1467 T1466 arg2Of sensed,be
R736 T1467 T1472 arg1Of sensed,[
R737 T1471 T1467 arg1Of PRRs,sensed
R738 T1471 T1468 arg2Of PRRs,by
R739 T1471 T1469 arg1Of PRRs,specific
R740 T1471 T1470 arg1Of PRRs,intracellular
R741 T1473 T1472 arg2Of 3,[
R742 T1474 T1472 arg3Of ],[
R743 T1477 T1475 arg1Of receptors,Endosomal
R744 T1477 T1476 arg1Of receptors,Toll-like
R745 T1477 T1478 arg1Of receptors,(
R746 T1477 T1481 arg1Of receptors,and
R747 T1479 T1478 arg2Of TLRs,(
R748 T1480 T1478 arg3Of ),(
R749 T1481 T1490 arg1Of and,or
R750 T1486 T1481 arg2Of receptors,and
R751 T1486 T1482 arg1Of receptors,cytoplasmic
R752 T1486 T1483 arg1Of receptors,RNA
R753 T1486 T1484 arg1Of receptors,helicase
R754 T1486 T1485 arg1Of receptors,RIG-I-like
R755 T1486 T1487 arg1Of receptors,(
R756 T1488 T1487 arg2Of RLRs,(
R757 T1489 T1487 arg3Of ),(
R758 T1490 T1496 arg1Of or,detect
R759 T1492 T1490 arg2Of receptors,or
R760 T1492 T1491 arg1Of receptors,Nod-like
R761 T1492 T1493 arg1Of receptors,(
R762 T1494 T1493 arg2Of NLRs,(
R763 T1495 T1493 arg3Of ),(
R764 T1498 T1496 arg2Of presence,detect
R765 T1498 T1497 arg1Of presence,the
R766 T1498 T1499 arg1Of presence,of
R767 T1502 T1500 arg1Of stranded,viral
R768 T1502 T1501 arg1Of stranded,single
R769 T1504 T1502 arg1Of TLR7,stranded
R770 T1504 T1503 arg2Of TLR7,(
R771 T1504 T1505 arg1Of TLR7,","
R772 T1504 T1507 arg1Of TLR7,","
R773 T1504 T1510 arg1Of TLR7,or
R774 T1506 T1505 arg2Of TLR8,","
R775 T1508 T1507 arg2Of Nod2,","
R776 T1509 T1503 arg3Of ),(
R777 T1510 T1499 arg2Of or,of
R778 T1513 T1510 arg2Of RNA,or
R779 T1513 T1511 arg1Of RNA,double
R780 T1513 T1512 arg1Of RNA,stranded
R781 T1513 T1514 arg1Of RNA,(
R782 T1515 T1514 arg2Of TLR3,(
R783 T1515 T1516 arg1Of TLR3,","
R784 T1515 T1518 arg1Of TLR3,","
R785 T1517 T1516 arg2Of RIG-I,","
R786 T1519 T1518 arg2Of MDA5,","
R787 T1520 T1514 arg3Of ),(
R788 T1523 T1521 arg1Of sensors,Intracellular
R789 T1523 T1522 arg1Of sensors,DNA
R790 T1523 T1524 arg1Of sensors,that
R791 T1523 T1525 arg1Of sensors,mediate
R792 T1523 T1532 arg1Of sensors,include
R793 T1528 T1525 arg2Of responses,mediate
R794 T1528 T1526 arg1Of responses,antiviral
R795 T1528 T1527 arg1Of responses,immune
R796 T1528 T1529 arg1Of responses,to
R797 T1531 T1529 arg2Of viruses,to
R798 T1531 T1530 arg1Of viruses,DNA
R799 T1533 T1534 arg1Of TLR9,","
R800 T1533 T1539 arg1Of TLR9,and
R801 T1535 T1534 arg2Of DAI,","
R802 T1535 T1536 arg1Of DAI,[
R803 T1537 T1536 arg2Of 4,[
R804 T1538 T1536 arg3Of ],[
R805 T1539 T1532 arg2Of and,include
R806 T1542 T1541 arg1Of domain,PYHIN
R807 T1542 T1543 arg1Of domain,containing
R808 T1542 T1557 arg1Of domain,and
R809 T1543 T1554 arg1Of containing,[
R810 T1545 T1543 arg2Of AIM2,containing
R811 T1545 T1544 arg1Of AIM2,proteins
R812 T1545 T1546 arg1Of AIM2,[
R813 T1545 T1549 arg1Of AIM2,","
R814 T1545 T1550 arg1Of AIM2,[
R815 T1545 T1553 arg1Of AIM2,","
R816 T1547 T1546 arg2Of 5,[
R817 T1548 T1546 arg3Of ],[
R818 T1551 T1550 arg2Of 6,[
R819 T1552 T1550 arg3Of ],[
R820 T1555 T1554 arg2Of 7,[
R821 T1556 T1554 arg3Of ],[
R822 T1557 T1539 arg2Of and,and
R823 T1557 T1540 arg1Of and,the
R824 T1558 T1557 arg2Of IFI16,and
R825 T1558 T1559 arg1Of IFI16,[
R826 T1560 T1559 arg2Of 8,[
R827 T1561 T1559 arg3Of ],[
R828 T1565 T1563 arg2Of responses,mediated
R829 T1565 T1564 arg1Of responses,antiviral
R830 T1565 T1566 arg1Of responses,are
R831 T1565 T1567 arg1Of responses,restricted
R832 T1566 T1562 arg1Of are,TLR
R833 T1567 T1566 arg2Of restricted,are
R834 T1567 T1568 arg1Of restricted,to
R835 T1572 T1568 arg2Of IFN,to
R836 T1572 T1569 arg2Of IFN,specialized
R837 T1572 T1570 arg1Of IFN,type
R838 T1572 T1571 arg1Of IFN,I
R839 T1572 T1573 arg1Of IFN,producing
R840 T1573 T1580 arg1Of producing,","
R841 T1573 T1581 arg1Of producing,while
R842 T1576 T1573 arg2Of cells,producing
R843 T1576 T1574 arg1Of cells,plasmacytoid
R844 T1576 T1575 arg1Of cells,dendritic
R845 T1576 T1577 arg1Of cells,(
R846 T1578 T1577 arg2Of pDC,(
R847 T1579 T1577 arg3Of ),(
R848 T1585 T1582 arg1Of types,most
R849 T1585 T1583 arg1Of types,other
R850 T1585 T1584 arg1Of types,cell
R851 T1585 T1586 arg1Of types,","
R852 T1585 T1587 arg1Of types,including
R853 T1585 T1593 arg1Of types,","
R854 T1589 T1587 arg2Of DC,including
R855 T1589 T1588 arg1Of DC,conventional
R856 T1589 T1590 arg1Of DC,(
R857 T1591 T1590 arg2Of cDC,(
R858 T1592 T1590 arg3Of ),(
R859 T1593 T1598 arg1Of ",",depend
R860 T1594 T1595 arg1Of macrophages,and
R861 T1595 T1593 arg2Of and,","
R862 T1596 T1595 arg2Of fibroblasts,and
R863 T1598 T1581 arg2Of depend,while
R864 T1598 T1597 arg1Of depend,","
R865 T1598 T1599 arg1Of depend,on
R866 T1602 T1603 arg1Of RNA,and
R867 T1604 T1603 arg2Of DNA,and
R868 T1605 T1599 arg2Of sensors,on
R869 T1605 T1600 arg1Of sensors,the
R870 T1605 T1601 arg1Of sensors,cytosolic
R871 T1605 T1602 arg1Of sensors,RNA
R872 T1605 T1604 arg1Of sensors,DNA
R873 T1605 T1606 arg1Of sensors,for
R874 T1608 T1606 arg2Of production,for
R875 T1608 T1607 arg1Of production,the
R876 T1608 T1609 arg1Of production,of
R877 T1608 T1612 arg1Of production,[
R878 T1611 T1609 arg2Of proteins,of
R879 T1611 T1610 arg1Of proteins,antiviral
R880 T1613 T1612 arg2Of 9,[
R881 T1614 T1612 arg3Of ],[
R882 T1617 T1615 arg1Of virus,Influenza
R883 T1617 T1616 arg1Of virus,A
R884 T1617 T1618 arg1Of virus,(
R885 T1617 T1621 arg1Of virus,is
R886 T1619 T1618 arg2Of IAV,(
R887 T1620 T1618 arg3Of ),(
R888 T1624 T1621 arg2Of agent,is
R889 T1624 T1622 arg1Of agent,the
R890 T1624 T1623 arg1Of agent,etiological
R891 T1624 T1625 arg1Of agent,of
R892 T1630 T1625 arg2Of disease,of
R893 T1630 T1626 arg1Of disease,a
R894 T1630 T1627 arg1Of disease,contagious
R895 T1630 T1628 arg1Of disease,acute
R896 T1630 T1629 arg1Of disease,respiratory
R897 T1630 T1631 arg1Of disease,that
R898 T1630 T1632 arg1Of disease,causes
R899 T1634 T1632 arg2Of mortality,causes
R900 T1634 T1633 arg1Of mortality,considerable
R901 T1634 T1635 arg1Of mortality,","
R902 T1634 T1636 arg1Of mortality,which
R903 T1634 T1637 arg1Of mortality,is
R904 T1634 T1639 arg2Of mortality,believed
R905 T1634 T1641 arg1Of mortality,be
R906 T1634 T1643 arg1Of mortality,to
R907 T1639 T1637 arg2Of believed,is
R908 T1639 T1638 arg1Of believed,generally
R909 T1641 T1639 arg3Of be,believed
R910 T1641 T1640 arg1Of be,to
R911 T1643 T1641 arg2Of to,be
R912 T1643 T1642 arg1Of to,due
R913 T1648 T1643 arg2Of response,to
R914 T1648 T1644 arg1Of response,an
R915 T1648 T1645 arg1Of response,excessive
R916 T1648 T1646 arg1Of response,host
R917 T1648 T1647 arg1Of response,inflammatory
R918 T1649 T1650 arg1Of Emergence,of
R919 T1649 T1659 arg1Of Emergence,underscores
R920 T1652 T1650 arg2Of strains,of
R921 T1652 T1651 arg1Of strains,drug-resistant
R922 T1652 T1653 arg1Of strains,of
R923 T1655 T1653 arg2Of viruses,of
R924 T1655 T1654 arg1Of viruses,influenza
R925 T1655 T1656 arg1Of viruses,with
R926 T1658 T1656 arg2Of potential,with
R927 T1658 T1657 arg1Of potential,pandemic
R928 T1661 T1659 arg2Of importance,underscores
R929 T1661 T1660 arg1Of importance,the
R930 T1661 T1662 arg1Of importance,of
R931 T1666 T1662 arg2Of strategies,of
R932 T1666 T1663 arg1Of strategies,developing
R933 T1666 T1664 arg1Of strategies,novel
R934 T1666 T1665 arg1Of strategies,antiviral
R935 T1669 T1667 arg2Of context,In
R936 T1669 T1668 arg1Of context,this
R937 T1671 T1672 arg1Of understanding,of
R938 T1671 T1680 arg1Of understanding,is
R939 T1671 T1681 arg1Of understanding,critical
R940 T1674 T1672 arg2Of mechanisms,of
R941 T1674 T1673 arg1Of mechanisms,the
R942 T1674 T1675 arg1Of mechanisms,that
R943 T1674 T1676 arg1Of mechanisms,regulate
R944 T1679 T1676 arg2Of responses,regulate
R945 T1679 T1677 arg1Of responses,IAV-induced
R946 T1679 T1678 arg1Of responses,immune
R947 T1680 T1667 arg1Of is,In
R948 T1680 T1670 arg1Of is,","
R949 T1681 T1680 arg2Of critical,is
R950 T1683 T1682 arg1Of infection,IAV
R951 T1683 T1684 arg1Of infection,leads
R952 T1684 T1685 arg1Of leads,to
R953 T1687 T1685 arg2Of exposure,to
R954 T1687 T1686 arg1Of exposure,the
R955 T1687 T1688 arg1Of exposure,in
R956 T1687 T1700 arg1Of exposure,","
R957 T1691 T1688 arg2Of cell,in
R958 T1691 T1689 arg1Of cell,the
R959 T1691 T1690 arg1Of cell,host
R960 T1691 T1692 arg1Of cell,of
R961 T1695 T1693 arg1Of RNA,single-stranded
R962 T1695 T1694 arg1Of RNA,genomic
R963 T1695 T1696 arg1Of RNA,and
R964 T1696 T1692 arg2Of and,of
R965 T1699 T1696 arg2Of RNA,and
R966 T1699 T1697 arg1Of RNA,double
R967 T1699 T1698 arg1Of RNA,stranded
R968 T1702 T1700 arg2Of latter,","
R969 T1702 T1701 arg1Of latter,the
R970 T1703 T1684 arg2Of being,leads
R971 T1705 T1703 arg2Of intermediate,being
R972 T1705 T1704 arg1Of intermediate,an
R973 T1705 T1706 arg1Of intermediate,of
R974 T1708 T1706 arg2Of replication,of
R975 T1708 T1707 arg1Of replication,viral
R976 T1709 T1710 arg1Of TLR3,and
R977 T1710 T1712 arg1Of and,have
R978 T1710 T1713 arg1Of and,been
R979 T1710 T1714 arg2Of and,implicated
R980 T1711 T1710 arg2Of RIG-I,and
R981 T1714 T1712 arg2Of implicated,have
R982 T1714 T1713 arg2Of implicated,been
R983 T1714 T1715 arg1Of implicated,as
R984 T1714 T1720 arg1Of implicated,[
R985 T1716 T1715 arg2Of sensors,as
R986 T1716 T1717 arg1Of sensors,of
R987 T1719 T1717 arg2Of infection,of
R988 T1719 T1718 arg1Of infection,IAV
R989 T1721 T1720 arg2Of 10,[
R990 T1722 T1720 arg3Of ],[
R991 T1723 T1714 arg3Of –,implicated
R992 T1723 T1724 arg1Of –,[
R993 T1725 T1724 arg2Of 12,[
R994 T1726 T1724 arg3Of ],[
R995 T1728 T1727 arg1Of receptors,Both
R996 T1728 T1729 arg1Of receptors,contribute
R997 T1729 T1730 arg1Of contribute,to
R998 T1729 T1737 arg1Of contribute,but
R999 T1733 T1730 arg2Of response,to
R1000 T1733 T1731 arg1Of response,the
R1001 T1733 T1732 arg1Of response,proinflammatory
R1002 T1733 T1734 arg1Of response,to
R1003 T1735 T1734 arg2Of IAV,to
R1004 T1737 T1736 arg1Of but,","
R1005 T1739 T1738 arg1Of initiation,the
R1006 T1739 T1740 arg1Of initiation,of
R1007 T1739 T1747 arg1Of initiation,depends
R1008 T1745 T1740 arg2Of response,of
R1009 T1745 T1741 arg1Of response,the
R1010 T1745 T1742 arg1Of response,innate
R1011 T1745 T1743 arg1Of response,antiviral
R1012 T1745 T1744 arg1Of response,immune
R1013 T1747 T1737 arg2Of depends,but
R1014 T1747 T1746 arg1Of depends,largely
R1015 T1747 T1748 arg1Of depends,on
R1016 T1747 T1752 arg1Of depends,[
R1017 T1751 T1748 arg2Of signaling,on
R1018 T1751 T1749 arg1Of signaling,RIG-I
R1019 T1751 T1750 arg2Of signaling,mediated
R1020 T1753 T1752 arg2Of 13,[
R1021 T1754 T1752 arg3Of ],[
R1022 T1759 T1757 arg1Of mice,RIG-I
R1023 T1759 T1758 arg1Of mice,deficient
R1024 T1759 T1760 arg1Of mice,are
R1025 T1759 T1762 arg1Of mice,susceptible
R1026 T1760 T1755 arg1Of are,Interestingly
R1027 T1760 T1756 arg1Of are,","
R1028 T1760 T1768 arg1Of are,","
R1029 T1760 T1769 arg1Of are,[
R1030 T1760 T1772 arg1Of are,","
R1031 T1760 T1773 arg1Of are,whereas
R1032 T1762 T1760 arg2Of susceptible,are
R1033 T1762 T1761 arg1Of susceptible,highly
R1034 T1762 T1763 arg1Of susceptible,to
R1035 T1764 T1763 arg2Of IAV,to
R1036 T1764 T1765 arg1Of IAV,[
R1037 T1766 T1765 arg2Of 14,[
R1038 T1767 T1765 arg3Of ],[
R1039 T1770 T1769 arg2Of 15,[
R1040 T1771 T1769 arg3Of ],[
R1041 T1776 T1774 arg1Of mice,TLR3
R1042 T1776 T1775 arg1Of mice,deficient
R1043 T1776 T1777 arg1Of mice,have
R1044 T1777 T1773 arg2Of have,whereas
R1045 T1777 T1781 arg1Of have,to
R1046 T1780 T1777 arg2Of advantage,have
R1047 T1780 T1778 arg1Of advantage,a
R1048 T1780 T1779 arg1Of advantage,survival
R1049 T1783 T1781 arg2Of infection,to
R1050 T1783 T1782 arg1Of infection,acute
R1051 T1783 T1784 arg1Of infection,[
R1052 T1785 T1784 arg2Of 16,[
R1053 T1786 T1784 arg3Of ],[
R1054 T1788 T1787 arg1Of results,These
R1055 T1788 T1789 arg1Of results,indicate
R1056 T1792 T1791 arg1Of imbalance,an
R1057 T1792 T1793 arg1Of imbalance,between
R1058 T1792 T1805 arg1Of imbalance,is
R1059 T1792 T1806 arg1Of imbalance,likely
R1060 T1792 T1808 arg1Of imbalance,contribute
R1061 T1795 T1796 arg1Of beneficial,and
R1062 T1797 T1796 arg2Of harmful,and
R1063 T1798 T1793 arg2Of effects,between
R1064 T1798 T1794 arg1Of effects,the
R1065 T1798 T1795 arg1Of effects,beneficial
R1066 T1798 T1797 arg1Of effects,harmful
R1067 T1798 T1799 arg1Of effects,of
R1068 T1800 T1799 arg2Of mediators,of
R1069 T1800 T1801 arg2Of mediators,released
R1070 T1804 T1801 arg1Of cells,released
R1071 T1804 T1802 arg2Of cells,by
R1072 T1804 T1803 arg1Of cells,immune
R1073 T1805 T1789 arg2Of is,indicate
R1074 T1805 T1790 arg1Of is,that
R1075 T1806 T1805 arg2Of likely,is
R1076 T1808 T1806 arg2Of contribute,likely
R1077 T1808 T1807 arg1Of contribute,to
R1078 T1808 T1809 arg1Of contribute,to
R1079 T1811 T1809 arg2Of pathogenesis,to
R1080 T1811 T1810 arg1Of pathogenesis,the
R1081 T1811 T1812 arg1Of pathogenesis,of
R1082 T1813 T1812 arg2Of influenza,of
R1083 T1814 T1815 arg1Of RIG-I,contains
R1084 T1821 T1815 arg2Of domain,contains
R1085 T1821 T1816 arg1Of domain,a
R1086 T1821 T1817 arg1Of domain,C-terminal
R1087 T1821 T1818 arg1Of domain,DExD/H
R1088 T1821 T1819 arg1Of domain,box
R1089 T1821 T1820 arg1Of domain,helicase
R1090 T1821 T1822 arg1Of domain,","
R1091 T1821 T1823 arg1Of domain,which
R1092 T1821 T1824 arg1Of domain,is
R1093 T1821 T1825 arg2Of domain,required
R1094 T1825 T1824 arg2Of required,is
R1095 T1825 T1826 arg1Of required,for
R1096 T1828 T1827 arg1Of recognition,ligand
R1097 T1828 T1830 arg1Of recognition,and
R1098 T1830 T1826 arg2Of and,for
R1099 T1830 T1829 arg1Of and,","
R1100 T1834 T1830 arg2Of domains,and
R1101 T1834 T1831 arg1Of domains,two
R1102 T1834 T1832 arg1Of domains,N-terminal
R1103 T1834 T1833 arg1Of domains,CARD
R1104 T1837 T1835 arg2Of binding,Upon
R1105 T1837 T1836 arg1Of binding,ligand
R1106 T1841 T1839 arg1Of domains,the
R1107 T1841 T1840 arg1Of domains,CARD
R1108 T1841 T1842 arg1Of domains,of
R1109 T1841 T1844 arg1Of domains,associate
R1110 T1843 T1842 arg2Of RIG-I,of
R1111 T1844 T1835 arg1Of associate,Upon
R1112 T1844 T1838 arg1Of associate,","
R1113 T1844 T1845 arg1Of associate,with
R1114 T1848 T1845 arg2Of domain,with
R1115 T1848 T1846 arg1Of domain,the
R1116 T1848 T1847 arg1Of domain,CARD
R1117 T1848 T1849 arg1Of domain,of
R1118 T1851 T1852 arg1Of MAVS,(
R1119 T1854 T1852 arg2Of termed,(
R1120 T1854 T1853 arg1Of termed,also
R1121 T1855 T1854 arg3Of IPS-1,termed
R1122 T1855 T1856 arg1Of IPS-1,","
R1123 T1855 T1858 arg1Of IPS-1,","
R1124 T1855 T1859 arg1Of IPS-1,Cardif
R1125 T1857 T1856 arg2Of VISA,","
R1126 T1860 T1852 arg3Of ),(
R1127 T1862 T1849 arg2Of protein,of
R1128 T1862 T1850 arg1Of protein,the
R1129 T1862 T1851 arg1Of protein,MAVS
R1130 T1862 T1861 arg1Of protein,adaptor
R1131 T1862 T1863 arg1Of protein,","
R1132 T1862 T1864 arg1Of protein,which
R1133 T1862 T1866 arg1Of protein,translocates
R1134 T1866 T1865 arg1Of translocates,subsequently
R1135 T1866 T1867 arg1Of translocates,to
R1136 T1866 T1870 arg1Of translocates,in
R1137 T1866 T1875 arg1Of translocates,via
R1138 T1866 T1880 arg1Of translocates,[
R1139 T1866 T1884 arg1Of translocates,[
R1140 T1869 T1867 arg2Of inserts,to
R1141 T1869 T1868 arg1Of inserts,and
R1142 T1874 T1870 arg2Of membrane,in
R1143 T1874 T1871 arg1Of membrane,the
R1144 T1874 T1872 arg1Of membrane,outer
R1145 T1874 T1873 arg1Of membrane,mitochondrial
R1146 T1879 T1875 arg2Of domain,via
R1147 T1879 T1876 arg1Of domain,its
R1148 T1879 T1877 arg1Of domain,C-terminal
R1149 T1879 T1878 arg1Of domain,transmembrane
R1150 T1881 T1880 arg2Of 17,[
R1151 T1882 T1880 arg3Of ],[
R1152 T1883 T1866 arg2Of –,translocates
R1153 T1885 T1884 arg2Of 20,[
R1154 T1886 T1884 arg3Of ],[
R1155 T1887 T1888 arg1Of Signaling,downstream
R1156 T1887 T1891 arg1Of Signaling,requires
R1157 T1888 T1889 arg1Of downstream,of
R1158 T1890 T1889 arg2Of MAVS,of
R1159 T1893 T1891 arg2Of action,requires
R1160 T1893 T1892 arg1Of action,the
R1161 T1893 T1894 arg1Of action,of
R1162 T1893 T1897 arg1Of action,modifying
R1163 T1896 T1894 arg2Of ubiquitin,of
R1164 T1948 T1947 arg1Of characterized,well
R1165 T1896 T1895 arg1Of ubiquitin,various
R1166 T1898 T1897 arg2Of enzymes,modifying
R1167 T1950 T1948 arg1Of ligases,characterized
R1168 T1950 T1949 arg1Of ligases,ubiquitin
R1169 T1950 T1952 arg1Of ligases,as
R1170 T1950 T1961 arg1Of ligases,and
R1171 T1898 T1899 arg1Of enzymes,","
R1172 T1898 T1900 arg1Of enzymes,which
R1173 T1952 T1951 arg1Of as,such
R1174 T1953 T1952 arg2Of TRAF6,as
R1175 T1953 T1954 arg1Of TRAF6,[
R1176 T1953 T1957 arg1Of TRAF6,","
R1177 T1953 T1958 arg1Of TRAF6,[
R1178 T1955 T1954 arg2Of 25,[
R1179 T1898 T1905 arg1Of enzymes,regulate
R1180 T1956 T1954 arg3Of ],[
R1181 T1902 T1903 arg1Of positively,and
R1182 T1959 T1958 arg2Of 26,[
R1183 T1960 T1958 arg3Of ],[
R1184 T1961 T1966 arg1Of and,mediate
R1185 T1962 T1961 arg2Of TRAF3,and
R1186 T1962 T1963 arg1Of TRAF3,[
R1187 T1903 T1901 arg1Of and,both
R1188 T1964 T1963 arg2Of 27,[
R1189 T1965 T1963 arg3Of ],[
R1190 T1966 T1944 arg1Of mediate,In
R1191 T1966 T1946 arg1Of mediate,","
R1192 T1966 T1967 arg1Of mediate,respectively
R1193 T1966 T1972 arg1Of mediate,upon
R1194 T1904 T1903 arg2Of negatively,and
R1195 T1968 T1969 arg1Of NF-κB,and
R1196 T1969 T1966 arg2Of and,mediate
R1197 T1905 T1902 arg1Of regulate,positively
R1198 T1971 T1969 arg2Of activation,and
R1199 T1971 T1970 arg1Of activation,IRF3
R1200 T1905 T1904 arg1Of regulate,negatively
R1201 T1909 T1905 arg2Of transduction,regulate
R1202 T1974 T1972 arg2Of stimulation,upon
R1203 T1974 T1973 arg1Of stimulation,RIG-I
R1204 T1978 T1975 arg2Of hand,On
R1205 T1978 T1976 arg1Of hand,the
R1206 T1978 T1977 arg1Of hand,other
R1207 T1980 T1998 arg1Of deubiquitinating,[
R1208 T1980 T2001 arg1Of deubiquitinating,and
R1209 T1981 T1980 arg2Of enzymes,deubiquitinating
R1210 T1981 T1982 arg1Of enzymes,(
R1211 T1981 T1985 arg1Of enzymes,","
R1212 T1981 T1987 arg1Of enzymes,as
R1213 T1981 T1997 arg1Of enzymes,","
R1214 T1909 T1906 arg1Of transduction,RIG-I
R1215 T1983 T1982 arg2Of DUBs,(
R1216 T1909 T1907 arg1Of transduction,mediated
R1217 T1984 T1982 arg3Of ),(
R1218 T1909 T1908 arg1Of transduction,signal
R1219 T1909 T1910 arg1Of transduction,[
R1220 T1911 T1910 arg2Of 21,[
R1221 T1987 T1986 arg1Of as,such
R1222 T1988 T1989 arg1Of DUBA,[
R1223 T1988 T1992 arg1Of DUBA,","
R1224 T1990 T1989 arg2Of 28,[
R1225 T1991 T1989 arg3Of ],[
R1226 T1992 T1987 arg2Of ",",as
R1227 T1993 T1992 arg2Of CYLD,","
R1228 T1993 T1994 arg1Of CYLD,[
R1229 T1995 T1994 arg2Of 29,[
R1230 T1912 T1910 arg3Of ],[
R1231 T1996 T1994 arg3Of ],[
R1232 T1915 T1913 arg1Of ligases,K63-specific
R1233 T1999 T1998 arg2Of 30,[
R1234 T2000 T1998 arg3Of ],[
R1235 T2001 T2006 arg1Of and,have
R1236 T2001 T2007 arg1Of and,been
R1237 T2001 T2008 arg2Of and,shown
R1238 T2001 T2011 arg1Of and,regulate
R1239 T2002 T2001 arg2Of OTUB1/2,and
R1240 T2002 T2003 arg1Of OTUB1/2,[
R1241 T2004 T2003 arg2Of 31,[
R1242 T1915 T1914 arg1Of ligases,ubiquitin
R1243 T2005 T2003 arg3Of ],[
R1244 T1915 T1916 arg1Of ligases,(
R1245 T1915 T1919 arg1Of ligases,","
R1246 T1915 T1921 arg1Of ligases,as
R1247 T2008 T1975 arg1Of shown,On
R1248 T2008 T1979 arg1Of shown,","
R1249 T2008 T2006 arg2Of shown,have
R1250 T1915 T1931 arg1Of ligases,","
R1251 T2008 T2007 arg2Of shown,been
R1252 T1915 T1932 arg1Of ligases,[
R1253 T1915 T1936 arg1Of ligases,have
R1254 T2011 T2008 arg3Of regulate,shown
R1255 T2011 T2009 arg1Of regulate,to
R1256 T2011 T2010 arg1Of regulate,negatively
R1257 T2011 T2014 arg1Of regulate,by
R1258 T2013 T2011 arg2Of signaling,regulate
R1259 T2013 T2012 arg1Of signaling,RLR
R1260 T1915 T1937 arg1Of ligases,been
R1261 T1915 T1938 arg2Of ligases,shown
R1262 T1915 T1941 arg1Of ligases,promote
R1263 T2016 T2014 arg2Of removing,by
R1264 T2016 T2015 arg1Of removing,specifically
R1265 T2016 T2020 arg1Of removing,from
R1266 T1917 T1916 arg2Of E3s,(
R1267 T2019 T2016 arg2Of chains,removing
R1268 T2019 T2017 arg1Of chains,K63-linked
R1269 T2019 T2018 arg1Of chains,polyubiquitin
R1270 T1918 T1916 arg3Of ),(
R1271 T2023 T2020 arg2Of molecules,from
R1272 T2023 T2021 arg1Of molecules,several
R1273 T2023 T2022 arg1Of molecules,signaling
R1274 T1921 T1920 arg1Of as,such
R1275 T2029 T2026 arg1Of ligases,various
R1276 T2029 T2027 arg1Of ligases,K48-specific
R1277 T2029 T2028 arg1Of ligases,ubiquitin
R1278 T2029 T2030 arg1Of ligases,","
R1279 T2029 T2032 arg1Of ligases,as
R1280 T2029 T2051 arg1Of ligases,","
R1281 T2029 T2053 arg1Of ligases,inhibiting
R1282 T1922 T1923 arg1Of TRIM25,[
R1283 T2032 T2031 arg1Of as,such
R1284 T2033 T2034 arg1Of AIP4,[
R1285 T2033 T2037 arg1Of AIP4,and
R1286 T1922 T1926 arg1Of TRIM25,and
R1287 T1924 T1923 arg2Of 22,[
R1288 T2035 T2034 arg2Of 32,[
R1289 T2036 T2034 arg3Of ],[
R1290 T2037 T2032 arg2Of and,as
R1291 T1925 T1923 arg3Of ],[
R1292 T2040 T2039 arg2Of 33,[
R1293 T1926 T1921 arg2Of and,as
R1294 T2041 T2039 arg3Of ],[
R1295 T2042 T2038 arg1Of mark,TRIAD3A
R1296 T2042 T2039 arg1Of mark,[
R1297 T2042 T2043 arg1Of mark,respectively
R1298 T1927 T1926 arg2Of Riplet,and
R1299 T1927 T1928 arg1Of Riplet,[
R1300 T1929 T1928 arg2Of 23,[
R1301 T1930 T1928 arg3Of ],[
R1302 T2044 T2045 arg1Of MAVS,and
R1303 T2045 T2037 arg2Of and,and
R1304 T2045 T2042 arg1Of and,mark
R1305 T2045 T2047 arg1Of and,for
R1306 T1933 T1932 arg2Of 24,[
R1307 T2046 T2045 arg2Of TRAF3,and
R1308 T2050 T2047 arg2Of degradation,for
R1309 T2050 T2048 arg1Of degradation,proteasome
R1310 T2050 T2049 arg2Of degradation,mediated
R1311 T1934 T1932 arg3Of ],[
R1312 T2053 T2024 arg1Of inhibiting,Furthermore
R1313 T2053 T2025 arg1Of inhibiting,","
R1314 T2053 T2052 arg1Of inhibiting,thus
R1315 T1938 T1935 arg1Of shown,","
R1316 T2056 T2053 arg2Of signaling,inhibiting
R1317 T2056 T2054 arg1Of signaling,further
R1318 T2056 T2055 arg1Of signaling,downstream
R1319 T2060 T2059 arg1Of attachment,the
R1320 T2060 T2061 arg1Of attachment,of
R1321 T2060 T2065 arg1Of attachment,to
R1322 T2060 T2072 arg1Of attachment,by
R1323 T2060 T2091 arg1Of attachment,dampens
R1324 T1938 T1936 arg2Of shown,have
R1325 T2064 T2061 arg2Of chains,of
R1326 T2064 T2062 arg1Of chains,K48-specific
R1327 T2064 T2063 arg1Of chains,polyubiquitin
R1328 T1938 T1937 arg2Of shown,been
R1329 T2067 T2068 arg1Of IRF3,and
R1330 T1941 T1938 arg3Of promote,shown
R1331 T2069 T2068 arg2Of IRF7,and
R1332 T2071 T2065 arg2Of factors,to
R1333 T2071 T2066 arg1Of factors,the
R1334 T2071 T2067 arg1Of factors,IRF3
R1335 T2071 T2069 arg1Of factors,IRF7
R1336 T2071 T2070 arg1Of factors,transcription
R1337 T2073 T2072 arg2Of E3s,by
R1338 T2073 T2075 arg1Of E3s,as
R1339 T1941 T1939 arg1Of promote,to
R1340 T2075 T2074 arg1Of as,such
R1341 T1941 T1940 arg1Of promote,directly
R1342 T2076 T2077 arg1Of RAUL,[
R1343 T2076 T2080 arg1Of RAUL,","
R1344 T1943 T1941 arg2Of activation,promote
R1345 T2078 T2077 arg2Of 34,[
R1346 T2079 T2077 arg3Of ],[
R1347 T2080 T2085 arg1Of ",",and
R1348 T1943 T1942 arg1Of activation,RIG-I
R1349 T2081 T2080 arg2Of TRIM21,","
R1350 T2081 T2082 arg1Of TRIM21,[
R1351 T1945 T1944 arg2Of addition,In
R1352 T2083 T2082 arg2Of 35,[
R1353 T2084 T2082 arg3Of ],[
R1354 T2085 T2075 arg2Of and,as
R1355 T2142 T2141 arg2Of response,in
R1356 T2086 T2085 arg2Of RBCK1,and
R1357 T2086 T2087 arg1Of RBCK1,[
R1358 T2088 T2087 arg2Of 36,[
R1359 T2089 T2087 arg3Of ],[
R1360 T2091 T2057 arg1Of dampens,Additionally
R1361 T2091 T2058 arg1Of dampens,","
R1362 T2091 T2090 arg1Of dampens,further
R1363 T2142 T2143 arg1Of response,to
R1364 T2145 T2143 arg2Of receptors,to
R1365 T2094 T2091 arg2Of transduction,dampens
R1366 T2094 T2092 arg1Of transduction,antiviral
R1367 T2094 T2093 arg1Of transduction,signal
R1368 T2095 T2096 arg1Of A20,is
R1369 T2145 T2144 arg1Of receptors,multiple
R1370 T2099 T2096 arg2Of enzyme,is
R1371 T2099 T2097 arg1Of enzyme,an
R1372 T2099 T2098 arg1Of enzyme,ubiquitin-editing
R1373 T2099 T2100 arg1Of enzyme,belonging
R1374 T2100 T2101 arg1Of belonging,to
R1375 T2145 T2147 arg1Of receptors,as
R1376 T2104 T2101 arg2Of family,to
R1377 T2147 T2146 arg1Of as,such
R1378 T2104 T2102 arg1Of family,the
R1379 T2104 T2103 arg1Of family,OTU-domain
R1380 T2104 T2105 arg1Of family,of
R1381 T2106 T2105 arg2Of DUBs,of
R1382 T2149 T2148 arg1Of receptor,TNF
R1383 T2149 T2150 arg1Of receptor,I
R1384 T2152 T2151 arg2Of 37,[
R1385 T2109 T2111 arg1Of A20,harbors
R1386 T2111 T2107 arg1Of harbors,Interestingly
R1387 T2111 T2108 arg1Of harbors,","
R1388 T2111 T2110 arg1Of harbors,also
R1389 T2153 T2151 arg3Of ],[
R1390 T2154 T2149 arg1Of –,receptor
R1391 T2154 T2151 arg1Of –,[
R1392 T2154 T2155 arg1Of –,[
R1393 T2120 T2111 arg2Of activity,harbors
R1394 T2120 T2112 arg1Of activity,atypical
R1395 T2120 T2113 arg1Of activity,zinc
R1396 T2120 T2114 arg1Of activity,finger
R1397 T2120 T2115 arg1Of activity,dependent
R1398 T2120 T2116 arg1Of activity,K48-specific
R1399 T2120 T2117 arg1Of activity,E3
R1400 T2120 T2118 arg1Of activity,ubiquitin
R1401 T2120 T2119 arg1Of activity,ligase
R1402 T2154 T2158 arg1Of –,","
R1403 T2156 T2155 arg2Of 39,[
R1404 T2122 T2123 arg1Of catalytic,and
R1405 T2124 T2123 arg2Of noncatalytic,and
R1406 T2125 T2121 arg1Of mechanisms,Both
R1407 T2125 T2122 arg1Of mechanisms,catalytic
R1408 T2125 T2124 arg1Of mechanisms,noncatalytic
R1409 T2125 T2126 arg1Of mechanisms,were
R1410 T2125 T2128 arg2Of mechanisms,shown
R1411 T2125 T2130 arg1Of mechanisms,be
R1412 T2125 T2131 arg2Of mechanisms,involved
R1413 T2157 T2155 arg3Of ],[
R1414 T2128 T2126 arg2Of shown,were
R1415 T2128 T2127 arg1Of shown,previously
R1416 T2158 T2164 arg1Of ",",and
R1417 T2131 T2128 arg3Of involved,shown
R1418 T2131 T2129 arg1Of involved,to
R1419 T2131 T2130 arg2Of involved,be
R1420 T2131 T2132 arg1Of involved,in
R1421 T2131 T2141 arg1Of involved,in
R1422 T2159 T2158 arg2Of TLR4,","
R1423 T2135 T2132 arg2Of regulation,in
R1424 T2135 T2133 arg1Of regulation,the
R1425 T2135 T2134 arg1Of regulation,negative
R1426 T2135 T2136 arg1Of regulation,of
R1427 T2135 T2139 arg1Of regulation,by
R1428 T2138 T2136 arg2Of signaling,of
R1429 T2138 T2137 arg1Of signaling,proinflammatory
R1430 T2140 T2139 arg2Of A20,by
R1431 T2159 T2160 arg1Of TLR4,[
R1432 T2161 T2160 arg2Of 40,[
R1433 T2162 T2160 arg3Of ],[
R1434 T2164 T2147 arg2Of and,as
R1435 T2238 T2235 arg2Of response,on
R1436 T2238 T2236 arg1Of response,the
R1437 T2238 T2237 arg1Of response,inflammatory
R1438 T2164 T2163 arg1Of and,","
R1439 T2240 T2239 arg1Of relevance,The
R1440 T2240 T2241 arg1Of relevance,of
R1441 T2240 T2244 arg1Of relevance,for
R1442 T2240 T2247 arg1Of relevance,has
R1443 T2240 T2249 arg1Of relevance,been
R1444 T2240 T2250 arg2Of relevance,illustrated
R1445 T2165 T2164 arg2Of IL-1R,and
R1446 T2243 T2241 arg2Of findings,of
R1447 T2243 T2242 arg1Of findings,these
R1448 T2165 T2166 arg1Of IL-1R,[
R1449 T2246 T2244 arg2Of disease,for
R1450 T2246 T2245 arg1Of disease,human
R1451 T2167 T2166 arg2Of 41,[
R1452 T2168 T2166 arg3Of ],[
R1453 T2250 T2247 arg2Of illustrated,has
R1454 T2250 T2248 arg1Of illustrated,recently
R1455 T2250 T2249 arg2Of illustrated,been
R1456 T2250 T2251 arg1Of illustrated,through
R1457 T2171 T2169 arg1Of role,The
R1458 T2253 T2251 arg2Of identification,through
R1459 T2253 T2252 arg1Of identification,the
R1460 T2253 T2254 arg1Of identification,of
R1461 T2171 T2170 arg1Of role,anti-inflammatory
R1462 T2255 T2254 arg2Of polymorphisms,of
R1463 T2255 T2256 arg1Of polymorphisms,in
R1464 T2255 T2260 arg1Of polymorphisms,that
R1465 T2255 T2261 arg1Of polymorphisms,are
R1466 T2255 T2262 arg2Of polymorphisms,associated
R1467 T2171 T2172 arg1Of role,of
R1468 T2171 T2174 arg1Of role,is
R1469 T2171 T2176 arg2Of role,demonstrated
R1470 T2259 T2256 arg2Of locus,in
R1471 T2259 T2257 arg1Of locus,the
R1472 T2259 T2258 arg1Of locus,A20
R1473 T2173 T2172 arg2Of A20,of
R1474 T2262 T2261 arg2Of associated,are
R1475 T2262 T2263 arg1Of associated,with
R1476 T2266 T2264 arg1Of diseases,several
R1477 T2266 T2265 arg1Of diseases,autoimmune
R1478 T2266 T2267 arg1Of diseases,and
R1479 T2267 T2263 arg2Of and,with
R1480 T2176 T2174 arg2Of demonstrated,is
R1481 T2269 T2267 arg2Of inflammation,and
R1482 T2269 T2268 arg1Of inflammation,chronic
R1483 T2269 T2270 arg1Of inflammation,[
R1484 T2271 T2270 arg2Of 45,[
R1485 T2272 T2270 arg3Of ],[
R1486 T2273 T2275 arg1Of In,to
R1487 T2176 T2175 arg1Of demonstrated,clearly
R1488 T2274 T2273 arg2Of contrast,In
R1489 T2179 T2176 arg1Of fact,demonstrated
R1490 T2278 T2277 arg1Of established,well
R1491 T2179 T2177 arg2Of fact,by
R1492 T2279 T2273 arg3Of function,In
R1493 T2279 T2276 arg1Of function,its
R1494 T2279 T2278 arg1Of function,established
R1495 T2279 T2280 arg1Of function,in
R1496 T2179 T2178 arg1Of fact,the
R1497 T2282 T2280 arg2Of regulation,in
R1498 T2282 T2281 arg1Of regulation,the
R1499 T2282 T2283 arg1Of regulation,of
R1500 T2183 T2181 arg1Of mice,A20
R1501 T2285 T2283 arg2Of responses,of
R1502 T2285 T2284 arg1Of responses,proinflammatory
R1503 T2288 T2287 arg1Of role,the
R1504 T2288 T2289 arg1Of role,of
R1505 T2288 T2291 arg1Of role,in
R1506 T2288 T2298 arg1Of role,is
R1507 T2288 T2301 arg2Of role,described
R1508 T2288 T2303 arg2Of role,limited
R1509 T2290 T2289 arg2Of A20,of
R1510 T2183 T2182 arg1Of mice,deficient
R1511 T2183 T2184 arg1Of mice,die
R1512 T2184 T2179 arg2Of die,fact
R1513 T2293 T2291 arg2Of regulation,in
R1514 T2293 T2292 arg1Of regulation,the
R1515 T2293 T2294 arg1Of regulation,of
R1516 T2184 T2180 arg1Of die,that
R1517 T2297 T2294 arg2Of responses,of
R1518 T2297 T2295 arg1Of responses,antiviral
R1519 T2297 T2296 arg1Of responses,immune
R1520 T2184 T2185 arg1Of die,early
R1521 T2184 T2186 arg1Of die,after
R1522 T2300 T2299 arg1Of well,less
R1523 T2187 T2186 arg2Of birth,after
R1524 T2301 T2302 arg1Of described,and
R1525 T2302 T2273 arg1Of and,In
R1526 T2302 T2286 arg1Of and,","
R1527 T2302 T2298 arg2Of and,is
R1528 T2302 T2300 arg1Of and,well
R1529 T2303 T2302 arg2Of limited,and
R1530 T2303 T2304 arg1Of limited,to
R1531 T2306 T2304 arg2Of number,to
R1532 T2306 T2305 arg1Of number,a
R1533 T2306 T2307 arg1Of number,of
R1534 T2309 T2308 arg1Of vitro,in
R1535 T2310 T2307 arg2Of studies,of
R1536 T2310 T2309 arg1Of studies,vitro
R1537 T2310 T2311 arg1Of studies,using
R1538 T2311 T2319 arg1Of using,","
R1539 T2311 T2320 modOf using,indicating
R1540 T2187 T2188 arg1Of birth,due
R1541 T2312 T2313 arg1Of overexpression,or
R1542 T2313 T2311 arg2Of or,using
R1543 T2313 T2315 arg1Of or,in
R1544 T2188 T2189 arg1Of due,to
R1545 T2314 T2313 arg2Of silencing,or
R1546 T2192 T2190 arg1Of inflammation,severe
R1547 T2318 T2315 arg2Of lines,in
R1548 T2318 T2316 arg1Of lines,specific
R1549 T2318 T2317 arg1Of lines,cell
R1550 T2192 T2191 arg1Of inflammation,multi-organ
R1551 T2322 T2323 arg1Of A20,may
R1552 T2192 T2193 arg1Of inflammation,and
R1553 T2193 T2189 arg2Of and,to
R1554 T2322 T2324 arg1Of A20,regulate
R1555 T2194 T2193 arg2Of cachexia,and
R1556 T2324 T2320 arg2Of regulate,indicating
R1557 T2324 T2321 arg1Of regulate,that
R1558 T2324 T2323 arg2Of regulate,may
R1559 T2325 T2326 arg1Of RIG-I-,and
R1560 T2194 T2195 arg1Of cachexia,[
R1561 T2326 T2329 arg1Of and,to
R1562 T2326 T2331 arg1Of and,and
R1563 T2196 T2195 arg2Of 37,[
R1564 T2328 T2326 arg2Of signaling,and
R1565 T2328 T2327 arg1Of signaling,TLR3-induced
R1566 T2330 T2329 arg2Of NF-κB,to
R1567 T2331 T2324 arg2Of and,regulate
R1568 T2197 T2195 arg3Of ],[
R1569 T2199 T2198 arg1Of recently,More
R1570 T2334 T2333 arg2Of 49,[
R1571 T2202 T2201 arg1Of targeting,gene
R1572 T2335 T2333 arg3Of ],[
R1573 T2336 T2331 arg2Of –,and
R1574 T2336 T2332 arg1Of –,IRF-3
R1575 T2336 T2333 arg1Of –,[
R1576 T2336 T2337 arg1Of –,[
R1577 T2338 T2337 arg2Of 52,[
R1578 T2339 T2337 arg3Of ],[
R1579 T2202 T2203 arg1Of targeting,of
R1580 T2202 T2205 arg1Of targeting,in
R1581 T2202 T2209 arg1Of targeting,was
R1582 T2202 T2210 arg2Of targeting,shown
R1583 T2345 T2344 arg1Of vivo,in
R1584 T2202 T2212 arg1Of targeting,be
R1585 T2346 T2342 arg1Of role,the
R1586 T2346 T2343 arg1Of role,precise
R1587 T2346 T2345 arg1Of role,vivo
R1588 T2346 T2347 arg1Of role,of
R1589 T2346 T2349 arg1Of role,in
R1590 T2346 T2355 arg1Of role,remains
R1591 T2346 T2357 arg1Of role,be
R1592 T2346 T2358 arg2Of role,clarified
R1593 T2348 T2347 arg2Of A20,of
R1594 T2202 T2213 arg2Of targeting,associated
R1595 T2202 T2228 arg1Of targeting,illustrating
R1596 T2351 T2349 arg2Of response,in
R1597 T2351 T2350 arg1Of response,the
R1598 T2351 T2352 arg1Of response,to
R1599 T2204 T2203 arg2Of A20,of
R1600 T2354 T2352 arg2Of infection,to
R1601 T2354 T2353 arg1Of infection,viral
R1602 T2355 T2340 arg1Of remains,However
R1603 T2355 T2341 arg1Of remains,","
R1604 T2208 T2205 arg2Of types,in
R1605 T2358 T2355 arg2Of clarified,remains
R1606 T2358 T2356 arg1Of clarified,to
R1607 T2358 T2357 arg2Of clarified,be
R1608 T2208 T2206 arg1Of types,specific
R1609 T2208 T2207 arg1Of types,cell
R1610 T2210 T2199 arg1Of shown,recently
R1611 T2365 T2359 arg2Of mice,Using
R1612 T2365 T2360 arg1Of mice,myeloid
R1613 T2365 T2361 arg1Of mice,cell
R1614 T2365 T2362 arg1Of mice,specific
R1615 T2365 T2363 arg1Of mice,A20
R1616 T2365 T2364 arg1Of mice,knockout
R1617 T2365 T2366 arg1Of mice,(
R1618 T2365 T2369 arg1Of mice,that
R1619 T2365 T2370 arg1Of mice,were
R1620 T2365 T2372 arg2Of mice,generated
R1621 T2367 T2366 arg2Of A20myel-KO,(
R1622 T2368 T2366 arg3Of ),(
R1623 T2210 T2200 arg1Of shown,","
R1624 T2372 T2370 arg2Of generated,were
R1625 T2372 T2371 arg1Of generated,recently
R1626 T2372 T2373 arg1Of generated,in
R1627 T2375 T2376 arg1Of lab,and
R1628 T2210 T2209 arg2Of shown,was
R1629 T2210 T2226 arg1Of shown,","
R1630 T2377 T2376 arg2Of primary,and
R1631 T2210 T2228 modOf shown,illustrating
R1632 T2378 T2373 arg2Of cells,in
R1633 T2378 T2374 arg1Of cells,our
R1634 T2378 T2375 arg1Of cells,lab
R1635 T2378 T2377 arg1Of cells,primary
R1636 T2378 T2379 arg2Of cells,derived
R1637 T2379 T2380 arg1Of derived,of
R1638 T2213 T2210 arg3Of associated,shown
R1639 T2382 T2380 arg2Of mice,of
R1640 T2382 T2381 arg1Of mice,these
R1641 T2384 T2359 arg1Of we,Using
R1642 T2384 T2386 arg1Of we,provide
R1643 T2386 T2359 modOf provide,Using
R1644 T2386 T2383 arg1Of provide,","
R1645 T2386 T2385 arg1Of provide,here
R1646 T2387 T2386 arg2Of evidence,provide
R1647 T2213 T2211 arg1Of associated,to
R1648 T2213 T2212 arg2Of associated,be
R1649 T2213 T2214 arg1Of associated,with
R1650 T2389 T2390 arg1Of A20,is
R1651 T2390 T2387 arg2Of is,evidence
R1652 T2390 T2388 arg1Of is,that
R1653 T2215 T2216 arg1Of autoimmunity,and
R1654 T2394 T2390 arg2Of regulator,is
R1655 T2394 T2391 arg1Of regulator,a
R1656 T2394 T2392 arg1Of regulator,crucial
R1657 T2394 T2393 arg1Of regulator,negative
R1658 T2394 T2395 arg1Of regulator,of
R1659 T2216 T2214 arg2Of and,with
R1660 T2220 T2219 arg2Of 42,[
R1661 T2397 T2398 arg1Of proinflammatory,and
R1662 T2399 T2398 arg2Of antiviral,and
R1663 T2400 T2395 arg2Of signaling,of
R1664 T2400 T2396 arg1Of signaling,IAV-induced
R1665 T2400 T2397 arg1Of signaling,proinflammatory
R1666 T2400 T2399 arg1Of signaling,antiviral
R1667 T2400 T2401 arg1Of signaling,in
R1668 T2402 T2401 arg2Of macrophages,in
R1669 T2221 T2219 arg3Of ],[
R1670 T2222 T2216 arg2Of –,and
R1671 T2406 T2405 arg1Of mice,A20myel-KO
R1672 T2406 T2407 arg1Of mice,show
R1673 T2407 T2403 arg1Of show,Interestingly
R1674 T2407 T2404 arg1Of show,","
R1675 T2407 T2413 arg1Of show,in
R1676 T2407 T2419 arg1Of show,compared
R1677 T2409 T2408 arg2Of survival,enhanced
R1678 T2409 T2410 arg1Of survival,and
R1679 T2410 T2407 arg2Of and,show
R1680 T2222 T2217 arg1Of –,chronic
R1681 T2412 T2410 arg2Of morbidity,and
R1682 T2412 T2411 arg2Of morbidity,reduced
R1683 T2222 T2218 arg1Of –,inflammation
R1684 T2414 T2413 arg2Of response,in
R1685 T2414 T2415 arg1Of response,to
R1686 T2222 T2219 arg1Of –,[
R1687 T2222 T2223 arg1Of –,[
R1688 T2224 T2223 arg2Of 48,[
R1689 T2418 T2415 arg2Of infection,to
R1690 T2418 T2416 arg1Of infection,IAV
R1691 T2418 T2417 arg1Of infection,lung
R1692 T2420 T2419 arg2Of to,compared
R1693 T2225 T2223 arg3Of ],[
R1694 T2423 T2420 arg2Of mice,to
R1695 T2423 T2421 arg1Of mice,wild
R1696 T2423 T2422 arg1Of mice,type
R1697 T2424 T2425 arg1Of Protection,against
R1698 T2424 T2427 arg1Of Protection,in
R1699 T2424 T2430 arg1Of Protection,is
R1700 T2424 T2431 arg2Of Protection,associated
R1701 T2424 T2439 arg1Of Protection,augmented
R1702 T2424 T2453 arg1Of Protection,enhanced
R1703 T2426 T2425 arg2Of IAV,against
R1704 T2228 T2227 arg1Of illustrating,further
R1705 T2429 T2427 arg2Of mice,in
R1706 T2429 T2428 arg1Of mice,A20myel-KO
R1707 T2431 T2430 arg2Of associated,is
R1708 T2431 T2432 arg1Of associated,with
R1709 T2431 T2438 arg1Of associated,","
R1710 T2230 T2231 arg1Of A20,is
R1711 T2231 T2228 arg2Of is,illustrating
R1712 T2231 T2229 arg1Of is,that
R1713 T2234 T2231 arg2Of brake,is
R1714 T2434 T2433 arg2Of cytokine,increased
R1715 T2434 T2435 arg1Of cytokine,and
R1716 T2435 T2432 arg2Of and,with
R1717 T2234 T2232 arg1Of brake,an
R1718 T2437 T2435 arg2Of production,and
R1719 T2437 T2436 arg1Of production,chemokine
R1720 T2234 T2233 arg1Of brake,important
R1721 T2438 T2452 arg1Of ",",and
R1722 T2234 T2235 arg1Of brake,on
R1723 T2439 T2438 arg2Of augmented,","
R1725 T2440 T2439 arg2Of recruitment,augmented
R1726 T2440 T2441 arg1Of recruitment,of
R1727 T2444 T2441 arg2Of cells,of
R1728 T2444 T2442 arg1Of cells,innate
R1729 T2444 T2443 arg1Of cells,immune
R1730 T2444 T2446 arg1Of cells,as
R1731 T2446 T2445 arg1Of as,such
R1732 T2447 T2448 arg1Of neutophils,and
R1733 T2448 T2446 arg2Of and,as
R1734 T2450 T2448 arg2Of macrophages,and
R1735 T2450 T2449 arg1Of macrophages,alveolar
R1737 T2452 T2451 arg1Of and,","
R1738 T2453 T2452 arg2Of enhanced,and
R1740 T2455 T2453 arg2Of clearance,enhanced
R1742 T2455 T2454 arg1Of clearance,viral
R1745 T2457 T2456 arg1Of results,These
R1746 T2457 T2458 arg1Of results,suggest
R1748 T2460 T2467 arg1Of boosting,by
R1751 T2460 T2474 arg1Of boosting,might
R1752 T2460 T2475 arg1Of boosting,have
R1754 T2464 T2460 arg2Of response,boosting
R1755 T2464 T2461 arg1Of response,the
R1756 T2464 T2462 arg1Of response,innate
R1757 T2464 T2463 arg1Of response,immune
R1758 T2464 T2465 arg1Of response,to
R1759 T2466 T2465 arg2Of IAV,to
R1761 T2468 T2467 arg2Of targeting,by
R1763 T2470 T2468 arg2Of activity,targeting
R1764 T2470 T2469 arg1Of activity,A20
R1765 T2470 T2471 arg1Of activity,in
R1767 T2473 T2471 arg2Of cells,in
R1768 T2473 T2472 arg1Of cells,myeloid
R1769 T2475 T2458 arg2Of have,suggest
R1770 T2475 T2459 arg1Of have,that
R1771 T2475 T2474 arg2Of have,might
R1773 T2477 T2475 arg2Of potential,have
R1774 T2477 T2476 arg1Of potential,therapeutic

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T1029 2939-2943 Antecedent denotes MAVS
T1028 2995-3000 Anaphor denotes which
R593 T1028 T1029 boundBy which,MAVS

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T1085 5669-5674 Protein denotes IRF-3
T1084 5633-5637 Protein denotes TLR3
T1083 5622-5627 Protein denotes RIG-I
T1082 4673-4678 Protein denotes IL-1R
T1081 4658-4662 Protein denotes TLR4
T1080 4632-4646 Protein denotes TNF receptor I
T1079 4204-4209 Protein denotes RBCK1
T1078 4188-4194 Protein denotes TRIM21
T1077 4177-4181 Protein denotes RAUL
T1076 4135-4139 Protein denotes IRF7
T1075 4126-4130 Protein denotes IRF3
T1074 3964-3969 Protein denotes TRAF3
T1073 3955-3959 Protein denotes MAVS
T1072 3924-3931 Protein denotes TRIAD3A
T1071 3910-3914 Protein denotes AIP4
T1070 3744-3747 Protein denotes RLR
T1069 3672-3676 Protein denotes CYLD
T1068 3661-3665 Protein denotes DUBA
T1067 3582-3587 Protein denotes RIG-I
T1066 3561-3565 Protein denotes IRF3
T1065 3519-3524 Protein denotes TRAF3
T1064 3498-3503 Protein denotes TRAF6
T1063 3422-3427 Protein denotes RIG-I
T1062 3367-3373 Protein denotes Riplet
T1061 3351-3357 Protein denotes TRIM25
T1060 3264-3269 Protein denotes RIG-I
T1059 3153-3157 Protein denotes MAVS
T1058 2970-2976 Protein denotes Cardif
T1057 2964-2968 Protein denotes VISA
T1056 2957-2962 Protein denotes IPS-1
T1055 2939-2943 Protein denotes MAVS
T1054 2895-2900 Protein denotes RIG-I
T1053 2723-2728 Protein denotes RIG-I
T1052 2472-2476 Protein denotes TLR3
T1051 2401-2406 Protein denotes RIG-I
T1050 2355-2360 Protein denotes RIG-I
T1049 2145-2150 Protein denotes RIG-I
T1048 2136-2140 Protein denotes TLR3
T1033 446-458 Protein denotes interferon-α
T1032 416-420 Protein denotes IL-1
T1031 407-411 Protein denotes IL-6
T1030 402-405 Protein denotes TNF
T1041 1009-1013 Protein denotes TLR3
T1040 979-983 Protein denotes Nod2
T1039 973-977 Protein denotes TLR8
T1038 967-971 Protein denotes TLR7
T1037 603-607 Protein denotes IRF7
T1036 594-598 Protein denotes IRF3
T1035 471-476 Protein denotes IFN-β
T1034 460-465 Protein denotes IFN-α
T1047 1196-1201 Protein denotes IFI16
T1046 1173-1177 Protein denotes AIM2
T1045 1124-1127 Protein denotes DAI
T1044 1118-1122 Protein denotes TLR9
T1043 1022-1026 Protein denotes MDA5
T1042 1015-1020 Protein denotes RIG-I

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T3682 4658-4662 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T3681 6511-6514 http://www.uniprot.org/uniprot/P21580 denotes A20
T3680 5957-5960 http://www.uniprot.org/uniprot/P21580 denotes A20
T3679 5815-5818 http://www.uniprot.org/uniprot/P21580 denotes A20
T3678 5723-5726 http://www.uniprot.org/uniprot/P21580 denotes A20
T3677 5605-5608 http://www.uniprot.org/uniprot/P21580 denotes A20
T3676 5412-5415 http://www.uniprot.org/uniprot/P21580 denotes A20
T3675 5213-5216 http://www.uniprot.org/uniprot/P21580 denotes A20
T3674 5026-5029 http://www.uniprot.org/uniprot/P21580 denotes A20
T3673 4892-4895 http://www.uniprot.org/uniprot/P21580 denotes A20
T3672 4760-4763 http://www.uniprot.org/uniprot/P21580 denotes A20
T3671 4715-4718 http://www.uniprot.org/uniprot/P21580 denotes A20
T3670 4586-4589 http://www.uniprot.org/uniprot/P21580 denotes A20
T3669 4356-4359 http://www.uniprot.org/uniprot/P21580 denotes A20
T3668 4262-4265 http://www.uniprot.org/uniprot/P21580 denotes A20
T3667 4204-4209 http://www.uniprot.org/uniprot/Q9BYM8 denotes RBCK1
T3666 3964-3969 http://www.uniprot.org/uniprot/Q13114 denotes TRAF3
T3665 3519-3524 http://www.uniprot.org/uniprot/Q13114 denotes TRAF3
T3664 3498-3503 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TRAF6
T3663 5633-5637 http://www.uniprot.org/uniprot/O15455 denotes TLR3
T3662 2472-2476 http://www.uniprot.org/uniprot/O15455 denotes TLR3
T3661 2136-2140 http://www.uniprot.org/uniprot/O15455 denotes TLR3
T3660 1009-1013 http://www.uniprot.org/uniprot/O15455 denotes TLR3
T3659 4135-4139 http://www.uniprot.org/uniprot/Q92985 denotes IRF7
T3658 603-607 http://www.uniprot.org/uniprot/Q92985 denotes IRF7
T3657 5669-5674 http://www.uniprot.org/uniprot/Q14653 denotes IRF-3
T3656 4126-4130 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T3655 3561-3565 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T3654 594-598 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T3653 588-592 http://www.uniprot.org/uniprot/P05412 denotes AP-1
T3652 464-474 http://www.uniprot.org/uniprot/P01562 denotes α) and IFN
T3651 457-463 http://www.uniprot.org/uniprot/P01562 denotes α (IFN
T3650 407-411 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T3649 4632-4635 http://www.uniprot.org/uniprot/P01375 denotes TNF
T3648 402-405 http://www.uniprot.org/uniprot/P01375 denotes TNF

UBERON-AE

Id Subject Object Predicate Lexical cue
T910 6159-6163 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T909 4821-4826 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organ

GO-BP

Id Subject Object Predicate Lexical cue
T1164 6468-6490 http://purl.obolibrary.org/obo/GO_0045824 denotes innate immune response
T1163 6468-6490 http://purl.obolibrary.org/obo/GO_0045089 denotes innate immune response
T1162 6468-6490 http://purl.obolibrary.org/obo/GO_0002218 denotes innate immune response
T1161 6468-6490 http://purl.obolibrary.org/obo/GO_0045088 denotes innate immune response
T1160 6468-6490 http://purl.obolibrary.org/obo/GO_0002227 denotes innate immune response
T1159 6376-6384 http://purl.obolibrary.org/obo/GO_0048286 denotes alveolar
T1158 6468-6490 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T1157 6333-6346 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T1156 6286-6306 http://purl.obolibrary.org/obo/GO_0032602 denotes chemokine production
T1155 5746-5761 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T1154 4673-4678 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1R
T1153 5423-5433 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T1152 5359-5369 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T1151 4543-4553 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T1150 4430-4445 http://purl.obolibrary.org/obo/GO_0016874 denotes ligase activity
T1149 4420-4445 http://purl.obolibrary.org/obo/GO_0034450 denotes ubiquitin ligase activity
T1148 4420-4445 http://purl.obolibrary.org/obo/GO_1904667 denotes ubiquitin ligase activity
T1147 4420-4445 http://purl.obolibrary.org/obo/GO_1904668 denotes ubiquitin ligase activity
T1146 4420-4445 http://purl.obolibrary.org/obo/GO_1990757 denotes ubiquitin ligase activity
T1145 4420-4445 http://purl.obolibrary.org/obo/GO_1904666 denotes ubiquitin ligase activity
T1144 4420-4445 http://purl.obolibrary.org/obo/GO_0050372 denotes ubiquitin ligase activity
T1143 4417-4419 http://purl.obolibrary.org/obo/GO_0061667 denotes E3
T1142 4417-4419 http://purl.obolibrary.org/obo/GO_0061666 denotes E3
T1141 4417-4419 http://purl.obolibrary.org/obo/GO_0061665 denotes E3
T1140 4417-4419 http://purl.obolibrary.org/obo/GO_0061664 denotes E3
T1139 4417-4419 http://purl.obolibrary.org/obo/GO_0061663 denotes E3
T1138 4417-4419 http://purl.obolibrary.org/obo/GO_0061662 denotes E3
T1137 4417-4419 http://purl.obolibrary.org/obo/GO_0061661 denotes E3
T1136 4417-4419 http://purl.obolibrary.org/obo/GO_0061660 denotes E3
T1135 4417-4419 http://purl.obolibrary.org/obo/GO_0061659 denotes E3
T1134 4420-4445 http://purl.obolibrary.org/obo/GO_0061630 denotes ubiquitin ligase activity
T1133 4417-4419 http://purl.obolibrary.org/obo/GO_0061630 denotes E3
T1132 4417-4419 http://purl.obolibrary.org/obo/GO_0019787 denotes E3
T1131 4420-4445 http://purl.obolibrary.org/obo/GO_0004842 denotes ubiquitin ligase activity
T1130 4417-4419 http://purl.obolibrary.org/obo/GO_0004842 denotes E3
T1129 3994-4005 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T1128 4098-4111 http://purl.obolibrary.org/obo/GO_0000209 denotes polyubiquitin
T1127 3794-3807 http://purl.obolibrary.org/obo/GO_0000209 denotes polyubiquitin
T1126 3620-3644 http://purl.obolibrary.org/obo/GO_0004843 denotes deubiquitinating enzymes
T1125 4248-4260 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T1124 3286-3298 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T1123 3270-3298 http://purl.obolibrary.org/obo/GO_0090520 denotes mediated signal transduction
T1122 3270-3298 http://purl.obolibrary.org/obo/GO_0038008 denotes mediated signal transduction
T1121 3270-3298 http://purl.obolibrary.org/obo/GO_0007266 denotes mediated signal transduction
T1120 3270-3298 http://purl.obolibrary.org/obo/GO_0048015 denotes mediated signal transduction
T1119 3270-3298 http://purl.obolibrary.org/obo/GO_0019933 denotes mediated signal transduction
T1118 3270-3298 http://purl.obolibrary.org/obo/GO_0007265 denotes mediated signal transduction
T1117 3270-3298 http://purl.obolibrary.org/obo/GO_0007263 denotes mediated signal transduction
T1116 3270-3298 http://purl.obolibrary.org/obo/GO_0016601 denotes mediated signal transduction
T1115 2696-2708 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T1114 5288-5300 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T1113 4976-4988 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T1112 4827-4839 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T1111 1694-1715 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T1110 1220-1239 http://purl.obolibrary.org/obo/GO_0051607 denotes antiviral responses
T1109 718-737 http://purl.obolibrary.org/obo/GO_0019083 denotes viral transcription
T1108 2117-2134 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T1107 682-699 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T1106 2117-2134 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T1105 682-699 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T1104 677-699 http://purl.obolibrary.org/obo/GO_0039693 denotes DNA, viral replication
T1103 669-699 http://purl.obolibrary.org/obo/GO_0039688 denotes RNA and DNA, viral replication
T1102 4140-4153 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T1101 724-737 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T1100 551-564 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T1099 4241-4260 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T1098 3279-3298 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T1097 511-529 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T1096 6038-6047 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T1095 5646-5655 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T1094 4573-4582 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T1093 4042-4051 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T1092 3828-3837 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T1091 3748-3757 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T1090 2370-2379 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T1089 511-520 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T1088 6475-6490 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T1087 2320-2335 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T1086 162-177 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response

GO-MF

Id Subject Object Predicate Lexical cue
T1200 4673-4678 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1R
T1199 4430-4445 http://purl.obolibrary.org/obo/GO_0016874 denotes ligase activity
T1198 4420-4445 http://purl.obolibrary.org/obo/GO_0034450 denotes ubiquitin ligase activity
T1197 4420-4445 http://purl.obolibrary.org/obo/GO_1990757 denotes ubiquitin ligase activity
T1196 4420-4445 http://purl.obolibrary.org/obo/GO_0050372 denotes ubiquitin ligase activity
T1195 4417-4419 http://purl.obolibrary.org/obo/GO_0061667 denotes E3
T1194 4417-4419 http://purl.obolibrary.org/obo/GO_0061666 denotes E3
T1193 4417-4419 http://purl.obolibrary.org/obo/GO_0061665 denotes E3
T1192 4417-4419 http://purl.obolibrary.org/obo/GO_0061664 denotes E3
T1191 4417-4419 http://purl.obolibrary.org/obo/GO_0061663 denotes E3
T1190 4417-4419 http://purl.obolibrary.org/obo/GO_0061662 denotes E3
T1189 4417-4419 http://purl.obolibrary.org/obo/GO_0061661 denotes E3
T1188 4417-4419 http://purl.obolibrary.org/obo/GO_0061660 denotes E3
T1187 4417-4419 http://purl.obolibrary.org/obo/GO_0061659 denotes E3
T1186 4420-4445 http://purl.obolibrary.org/obo/GO_0061630 denotes ubiquitin ligase activity
T1185 4417-4419 http://purl.obolibrary.org/obo/GO_0061630 denotes E3
T1184 4417-4419 http://purl.obolibrary.org/obo/GO_0019787 denotes E3
T1183 4420-4445 http://purl.obolibrary.org/obo/GO_0004842 denotes ubiquitin ligase activity
T1182 4417-4419 http://purl.obolibrary.org/obo/GO_0004842 denotes E3
T1181 3620-3644 http://purl.obolibrary.org/obo/GO_0004843 denotes deubiquitinating enzymes
T1180 4420-4429 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T1179 4272-4281 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T1178 3883-3892 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T1177 3472-3481 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T1176 3318-3327 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T1175 3189-3198 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T1174 2866-2873 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T1173 2859-2865 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T1172 2801-2807 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T1171 416-430 http://purl.obolibrary.org/obo/GO_0005151 denotes IL-1) and type
T1170 416-430 http://purl.obolibrary.org/obo/GO_0005150 denotes IL-1) and type
T1169 416-420 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T1168 407-411 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T1167 213-242 http://purl.obolibrary.org/obo/GO_0038187 denotes pattern recognition receptors

GO-CC

Id Subject Object Predicate Lexical cue
T1226 3974-3984 http://purl.obolibrary.org/obo/GO_0000502 denotes proteasome
T1225 3097-3110 http://purl.obolibrary.org/obo/GO_0044214 denotes transmembrane
T1224 3097-3110 http://purl.obolibrary.org/obo/GO_0016021 denotes transmembrane
T1223 3069-3077 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T1222 3055-3077 http://purl.obolibrary.org/obo/GO_0031966 denotes mitochondrial membrane
T1221 3049-3077 http://purl.obolibrary.org/obo/GO_0031315 denotes outer mitochondrial membrane
T1220 3049-3077 http://purl.obolibrary.org/obo/GO_0031307 denotes outer mitochondrial membrane
T1219 3049-3077 http://purl.obolibrary.org/obo/GO_0031306 denotes outer mitochondrial membrane
T1218 3049-3077 http://purl.obolibrary.org/obo/GO_0005741 denotes outer mitochondrial membrane
T1217 1029-1042 http://purl.obolibrary.org/obo/GO_0005622 denotes Intracellular
T1216 774-787 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T1215 6535-6540 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T1214 6347-6352 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T1213 5898-5903 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T1212 5801-5805 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1211 5577-5581 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1210 4908-4912 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1209 2020-2024 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1208 1344-1348 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1207 86-90 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1206 2015-2024 http://purl.obolibrary.org/obo/GO_0043657 denotes host cell
T1205 81-90 http://purl.obolibrary.org/obo/GO_0043657 denotes host cell
T1204 2015-2019 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T1203 1689-1693 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T1202 365-369 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T1201 81-85 http://purl.obolibrary.org/obo/GO_0018995 denotes host

sentences

Id Subject Object Predicate Lexical cue
T945 6428-6574 Sentence denotes These results suggest that boosting the innate immune response to IAV by targeting A20 activity in myeloid cells might have therapeutic potential.
T944 6202-6427 Sentence denotes Protection against IAV in A20myel-KO mice is associated with increased cytokine and chemokine production, augmented recruitment of innate immune cells such as neutophils and alveolar macrophages, and enhanced viral clearance.
T943 6064-6201 Sentence denotes Interestingly, A20myel-KO mice show enhanced survival and reduced morbidity in response to IAV lung infection compared to wild type mice.
T942 5787-6063 Sentence denotes Using myeloid cell specific A20 knockout mice (A20myel-KO) that were recently generated in our lab and primary cells derived of these mice, we here provide evidence that A20 is a crucial negative regulator of IAV-induced proinflammatory and antiviral signaling in macrophages.
T941 5686-5786 Sentence denotes However, the precise in vivo role of A20 in the response to viral infection remains to be clarified.
T940 5307-5685 Sentence denotes In contrast to its well established function in the regulation of proinflammatory responses, the role of A20 in the regulation of antiviral immune responses is less well described and limited to a number of in vitro studies using overexpression or silencing in specific cell lines, indicating that A20 may regulate RIG-I- and TLR3-induced signaling to NF-κB and IRF-3 [49]–[52].
T939 5082-5306 Sentence denotes The relevance of these findings for human disease has recently been illustrated through the identification of polymorphisms in the A20 locus that are associated with several autoimmune diseases and chronic inflammation [45].
T938 4859-5081 Sentence denotes More recently, gene targeting of A20 in specific cell types was shown to be associated with autoimmunity and chronic inflammation [42]–[48], further illustrating that A20 is an important brake on the inflammatory response.
T937 4685-4858 Sentence denotes The anti-inflammatory role of A20 is clearly demonstrated by the fact that A20 deficient mice die early after birth due to severe multi-organ inflammation and cachexia [37].
T936 4447-4684 Sentence denotes Both catalytic and noncatalytic mechanisms were previously shown to be involved in the negative regulation of proinflammatory signaling by A20 in response to multiple receptors such as TNF receptor I [37]–[39], TLR4 [40], and IL-1R [41].
T935 4341-4446 Sentence denotes Interestingly, A20 also harbors atypical zinc finger dependent K48-specific E3 ubiquitin ligase activity.
T934 4262-4340 Sentence denotes A20 is an ubiquitin-editing enzyme belonging to the OTU-domain family of DUBs.
T933 4053-4261 Sentence denotes Additionally, the attachment of K48-specific polyubiquitin chains to the IRF3 and IRF7 transcription factors by E3s such as RAUL [34], TRIM21 [35] and RBCK1 [36] further dampens antiviral signal transduction.
T932 3849-4052 Sentence denotes Furthermore, various K48-specific ubiquitin ligases, such as AIP4 [32] and TRIAD3A [33] mark respectively MAVS and TRAF3 for proteasome mediated degradation, thus inhibiting further downstream signaling.
T931 3601-3848 Sentence denotes On the other hand, deubiquitinating enzymes (DUBs), such as DUBA [28], CYLD [29], [30] and OTUB1/2 [31] have been shown to negatively regulate RLR signaling by specifically removing K63-linked polyubiquitin chains from several signaling molecules.
T930 3440-3600 Sentence denotes In addition, well characterized ubiquitin ligases such as TRAF6 [25], [26] and TRAF3 [27] mediate respectively NF-κB and IRF3 activation upon RIG-I stimulation.
T929 3305-3439 Sentence denotes K63-specific ubiquitin ligases (E3s), such as TRIM25 [22] and Riplet [23], [24], have been shown to directly promote RIG-I activation.
T928 3129-3304 Sentence denotes Signaling downstream of MAVS requires the action of various ubiquitin modifying enzymes, which both positively and negatively regulate RIG-I mediated signal transduction [21].
T927 2854-3128 Sentence denotes Upon ligand binding, the CARD domains of RIG-I associate with the CARD domain of the MAVS (also termed IPS-1, VISA, Cardif) adaptor protein, which subsequently translocates to and inserts in the outer mitochondrial membrane via its C-terminal transmembrane domain [17]–[20].
T926 2723-2853 Sentence denotes RIG-I contains a C-terminal DExD/H box helicase domain, which is required for ligand recognition, and two N-terminal CARD domains.
T925 2543-2722 Sentence denotes These results indicate that an imbalance between the beneficial and harmful effects of mediators released by immune cells is likely to contribute to the pathogenesis of influenza.
T924 2386-2542 Sentence denotes Interestingly, RIG-I deficient mice are highly susceptible to IAV [14], [15], whereas TLR3 deficient mice have a survival advantage to acute infection [16].
T923 2211-2385 Sentence denotes Both receptors contribute to the proinflammatory response to IAV, but the initiation of the innate antiviral immune response largely depends on RIG-I mediated signaling [13].
T922 2136-2210 Sentence denotes TLR3 and RIG-I have been implicated as sensors of IAV infection [10]–[12].
T921 1972-2135 Sentence denotes IAV infection leads to the exposure in the host cell of single-stranded genomic RNA and double stranded RNA, the latter being an intermediate of viral replication.
T920 1867-1971 Sentence denotes In this context, understanding of the mechanisms that regulate IAV-induced immune responses is critical.
T919 1717-1866 Sentence denotes Emergence of drug-resistant strains of influenza viruses with pandemic potential underscores the importance of developing novel antiviral strategies.
T918 1508-1716 Sentence denotes Influenza A virus (IAV) is the etiological agent of a contagious acute respiratory disease that causes considerable mortality, which is generally believed to be due to an excessive host inflammatory response.
T917 1207-1507 Sentence denotes TLR mediated antiviral responses are restricted to specialized type I IFN producing plasmacytoid dendritic cells (pDC), while most other cell types, including conventional DC (cDC), macrophages and fibroblasts, depend on the cytosolic RNA and DNA sensors for the production of antiviral proteins [9].
T916 1029-1206 Sentence denotes Intracellular DNA sensors that mediate antiviral immune responses to DNA viruses include TLR9, DAI [4] and the PYHIN domain containing proteins AIM2 [5], [6], [7] and IFI16 [8].
T915 798-1028 Sentence denotes Endosomal Toll-like receptors (TLRs) and cytoplasmic RNA helicase RIG-I-like receptors (RLRs) or Nod-like receptors (NLRs) detect the presence of viral single stranded (TLR7, TLR8, Nod2) or double stranded RNA (TLR3, RIG-I, MDA5).
T914 618-797 Sentence denotes The presence of viral nucleic acids, such as viral RNA and DNA, viral replication intermediates and viral transcription products, can be sensed by specific intracellular PRRs [3].
T913 320-617 Sentence denotes Triggering of PRRs induces the production of host proinflammatory cytokines (e.g. TNF, IL-6 and IL-1) and type I interferons (interferon-α (IFN-α) and IFN-β) through activation of downstream signaling pathways that control various transcription factors such as NF-κB, AP-1, IRF3 and IRF7 [1], [2].
T912 114-319 Sentence denotes The initiation of a protective innate antiviral immune response involves the action of specialized pattern recognition receptors (PRR), which detect conserved molecular structures of the invading pathogen.
T911 13-113 Sentence denotes Viruses are a class of highly diverse pathogens which depend on the host cell for their replication.
T21 0-12 Sentence denotes Introduction
T22 13-113 Sentence denotes Viruses are a class of highly diverse pathogens which depend on the host cell for their replication.
T23 114-319 Sentence denotes The initiation of a protective innate antiviral immune response involves the action of specialized pattern recognition receptors (PRR), which detect conserved molecular structures of the invading pathogen.
T24 320-617 Sentence denotes Triggering of PRRs induces the production of host proinflammatory cytokines (e.g. TNF, IL-6 and IL-1) and type I interferons (interferon-α (IFN-α) and IFN-β) through activation of downstream signaling pathways that control various transcription factors such as NF-κB, AP-1, IRF3 and IRF7 [1], [2].
T25 618-797 Sentence denotes The presence of viral nucleic acids, such as viral RNA and DNA, viral replication intermediates and viral transcription products, can be sensed by specific intracellular PRRs [3].
T26 798-1028 Sentence denotes Endosomal Toll-like receptors (TLRs) and cytoplasmic RNA helicase RIG-I-like receptors (RLRs) or Nod-like receptors (NLRs) detect the presence of viral single stranded (TLR7, TLR8, Nod2) or double stranded RNA (TLR3, RIG-I, MDA5).
T27 1029-1206 Sentence denotes Intracellular DNA sensors that mediate antiviral immune responses to DNA viruses include TLR9, DAI [4] and the PYHIN domain containing proteins AIM2 [5], [6], [7] and IFI16 [8].
T28 1207-1507 Sentence denotes TLR mediated antiviral responses are restricted to specialized type I IFN producing plasmacytoid dendritic cells (pDC), while most other cell types, including conventional DC (cDC), macrophages and fibroblasts, depend on the cytosolic RNA and DNA sensors for the production of antiviral proteins [9].
T29 1508-1716 Sentence denotes Influenza A virus (IAV) is the etiological agent of a contagious acute respiratory disease that causes considerable mortality, which is generally believed to be due to an excessive host inflammatory response.
T30 1717-1866 Sentence denotes Emergence of drug-resistant strains of influenza viruses with pandemic potential underscores the importance of developing novel antiviral strategies.
T31 1867-1971 Sentence denotes In this context, understanding of the mechanisms that regulate IAV-induced immune responses is critical.
T32 1972-2135 Sentence denotes IAV infection leads to the exposure in the host cell of single-stranded genomic RNA and double stranded RNA, the latter being an intermediate of viral replication.
T33 2136-2210 Sentence denotes TLR3 and RIG-I have been implicated as sensors of IAV infection [10]–[12].
T34 2211-2385 Sentence denotes Both receptors contribute to the proinflammatory response to IAV, but the initiation of the innate antiviral immune response largely depends on RIG-I mediated signaling [13].
T35 2386-2542 Sentence denotes Interestingly, RIG-I deficient mice are highly susceptible to IAV [14], [15], whereas TLR3 deficient mice have a survival advantage to acute infection [16].
T36 2543-2722 Sentence denotes These results indicate that an imbalance between the beneficial and harmful effects of mediators released by immune cells is likely to contribute to the pathogenesis of influenza.
T37 2723-2853 Sentence denotes RIG-I contains a C-terminal DExD/H box helicase domain, which is required for ligand recognition, and two N-terminal CARD domains.
T38 2854-3128 Sentence denotes Upon ligand binding, the CARD domains of RIG-I associate with the CARD domain of the MAVS (also termed IPS-1, VISA, Cardif) adaptor protein, which subsequently translocates to and inserts in the outer mitochondrial membrane via its C-terminal transmembrane domain [17]–[20].
T39 3129-3304 Sentence denotes Signaling downstream of MAVS requires the action of various ubiquitin modifying enzymes, which both positively and negatively regulate RIG-I mediated signal transduction [21].
T40 3305-3439 Sentence denotes K63-specific ubiquitin ligases (E3s), such as TRIM25 [22] and Riplet [23], [24], have been shown to directly promote RIG-I activation.
T41 3440-3600 Sentence denotes In addition, well characterized ubiquitin ligases such as TRAF6 [25], [26] and TRAF3 [27] mediate respectively NF-κB and IRF3 activation upon RIG-I stimulation.
T42 3601-3848 Sentence denotes On the other hand, deubiquitinating enzymes (DUBs), such as DUBA [28], CYLD [29], [30] and OTUB1/2 [31] have been shown to negatively regulate RLR signaling by specifically removing K63-linked polyubiquitin chains from several signaling molecules.
T43 3849-4052 Sentence denotes Furthermore, various K48-specific ubiquitin ligases, such as AIP4 [32] and TRIAD3A [33] mark respectively MAVS and TRAF3 for proteasome mediated degradation, thus inhibiting further downstream signaling.
T44 4053-4261 Sentence denotes Additionally, the attachment of K48-specific polyubiquitin chains to the IRF3 and IRF7 transcription factors by E3s such as RAUL [34], TRIM21 [35] and RBCK1 [36] further dampens antiviral signal transduction.
T45 4262-4340 Sentence denotes A20 is an ubiquitin-editing enzyme belonging to the OTU-domain family of DUBs.
T46 4341-4446 Sentence denotes Interestingly, A20 also harbors atypical zinc finger dependent K48-specific E3 ubiquitin ligase activity.
T47 4447-4684 Sentence denotes Both catalytic and noncatalytic mechanisms were previously shown to be involved in the negative regulation of proinflammatory signaling by A20 in response to multiple receptors such as TNF receptor I [37]–[39], TLR4 [40], and IL-1R [41].
T48 4685-4858 Sentence denotes The anti-inflammatory role of A20 is clearly demonstrated by the fact that A20 deficient mice die early after birth due to severe multi-organ inflammation and cachexia [37].
T49 4859-5081 Sentence denotes More recently, gene targeting of A20 in specific cell types was shown to be associated with autoimmunity and chronic inflammation [42]–[48], further illustrating that A20 is an important brake on the inflammatory response.
T50 5082-5306 Sentence denotes The relevance of these findings for human disease has recently been illustrated through the identification of polymorphisms in the A20 locus that are associated with several autoimmune diseases and chronic inflammation [45].
T51 5307-5685 Sentence denotes In contrast to its well established function in the regulation of proinflammatory responses, the role of A20 in the regulation of antiviral immune responses is less well described and limited to a number of in vitro studies using overexpression or silencing in specific cell lines, indicating that A20 may regulate RIG-I- and TLR3-induced signaling to NF-κB and IRF-3 [49]–[52].
T52 5686-5786 Sentence denotes However, the precise in vivo role of A20 in the response to viral infection remains to be clarified.
T53 5787-6063 Sentence denotes Using myeloid cell specific A20 knockout mice (A20myel-KO) that were recently generated in our lab and primary cells derived of these mice, we here provide evidence that A20 is a crucial negative regulator of IAV-induced proinflammatory and antiviral signaling in macrophages.
T54 6064-6201 Sentence denotes Interestingly, A20myel-KO mice show enhanced survival and reduced morbidity in response to IAV lung infection compared to wild type mice.
T55 6202-6427 Sentence denotes Protection against IAV in A20myel-KO mice is associated with increased cytokine and chemokine production, augmented recruitment of innate immune cells such as neutophils and alveolar macrophages, and enhanced viral clearance.
T56 6428-6574 Sentence denotes These results suggest that boosting the innate immune response to IAV by targeting A20 activity in myeloid cells might have therapeutic potential.

ICD10

Id Subject Object Predicate Lexical cue
T1166 5746-5761 http://purl.bioontology.org/ontology/ICD10/B34.9 denotes viral infection
T1165 4844-4852 http://purl.bioontology.org/ontology/ICD10/R64 denotes cachexia

simple1

Id Subject Object Predicate Lexical cue
T1338 5669-5674 Protein denotes IRF-3
T1337 5633-5637 Protein denotes TLR3
T1336 5622-5627 Protein denotes RIG-I
T1335 4673-4678 Protein denotes IL-1R
T1334 4658-4662 Protein denotes TLR4
T1333 4632-4646 Protein denotes TNF receptor I
T1332 4204-4209 Protein denotes RBCK1
T1331 4188-4194 Protein denotes TRIM21
T1330 4177-4181 Protein denotes RAUL
T1329 4135-4139 Protein denotes IRF7
T1328 4126-4130 Protein denotes IRF3
T1327 3964-3969 Protein denotes TRAF3
T1326 3955-3959 Protein denotes MAVS
T1325 3924-3931 Protein denotes TRIAD3A
T1324 3910-3914 Protein denotes AIP4
T1323 3744-3747 Protein denotes RLR
T1322 3672-3676 Protein denotes CYLD
T1321 3661-3665 Protein denotes DUBA
T1320 3582-3587 Protein denotes RIG-I
T1319 3561-3565 Protein denotes IRF3
T1318 3519-3524 Protein denotes TRAF3
T1317 3498-3503 Protein denotes TRAF6
T1316 3422-3427 Protein denotes RIG-I
T1315 3367-3373 Protein denotes Riplet
T1314 3351-3357 Protein denotes TRIM25
T1313 3264-3269 Protein denotes RIG-I
T1312 3153-3157 Protein denotes MAVS
T1311 2970-2976 Protein denotes Cardif
T1310 2964-2968 Protein denotes VISA
T1309 2957-2962 Protein denotes IPS-1
T1308 2939-2943 Protein denotes MAVS
T1307 2895-2900 Protein denotes RIG-I
T1306 2723-2728 Protein denotes RIG-I
T1305 2472-2476 Protein denotes TLR3
T1304 2401-2406 Protein denotes RIG-I
T1303 2355-2360 Protein denotes RIG-I
T1302 2145-2150 Protein denotes RIG-I
T1301 2136-2140 Protein denotes TLR3
T1300 1196-1201 Protein denotes IFI16
T1299 1173-1177 Protein denotes AIM2
T1298 1124-1127 Protein denotes DAI
T1297 1118-1122 Protein denotes TLR9
T1296 1022-1026 Protein denotes MDA5
T1295 1015-1020 Protein denotes RIG-I
T1294 1009-1013 Protein denotes TLR3
T1293 979-983 Protein denotes Nod2
T1292 973-977 Protein denotes TLR8
T1291 967-971 Protein denotes TLR7
T1290 603-607 Protein denotes IRF7
T1289 594-598 Protein denotes IRF3
T1288 471-476 Protein denotes IFN-β
T1287 460-465 Protein denotes IFN-α
T1286 446-458 Protein denotes interferon-α
T1285 416-420 Protein denotes IL-1
T1284 407-411 Protein denotes IL-6
T1283 402-405 Protein denotes TNF

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T4160 4071-4081 Binding denotes attachment
T4159 3994-4005 Protein_catabolism denotes degradation
T4158 3566-3576 Positive_regulation denotes activation
T4157 3428-3438 Positive_regulation denotes activation
T4156 3414-3421 Positive_regulation denotes promote
T4155 3014-3026 Localization denotes translocates
T4154 2901-2910 Binding denotes associate
T4153 2407-2416 Negative_regulation denotes deficient
T4152 2477-2486 Negative_regulation denotes deficient
T4151 339-346 Positive_regulation denotes induces
T4150 351-361 Gene_expression denotes production
T4149 5669-5674 Protein denotes IRF-3
T4148 5633-5637 Protein denotes TLR3
T4147 5622-5627 Protein denotes RIG-I
T4146 4673-4678 Protein denotes IL-1R
T4145 4658-4662 Protein denotes TLR4
T4144 4632-4646 Protein denotes TNF receptor I
T4143 4204-4209 Protein denotes RBCK1
T4142 4188-4194 Protein denotes TRIM21
T4141 4177-4181 Protein denotes RAUL
T4140 4135-4139 Protein denotes IRF7
T4139 4126-4130 Protein denotes IRF3
T4138 3964-3969 Protein denotes TRAF3
T4137 3955-3959 Protein denotes MAVS
T4136 3924-3931 Protein denotes TRIAD3A
T4135 3910-3914 Protein denotes AIP4
T4134 3744-3747 Protein denotes RLR
T4133 3672-3676 Protein denotes CYLD
T4132 3661-3665 Protein denotes DUBA
T4131 3582-3587 Protein denotes RIG-I
T4130 3561-3565 Protein denotes IRF3
T4129 3519-3524 Protein denotes TRAF3
T4128 3498-3503 Protein denotes TRAF6
T4127 3422-3427 Protein denotes RIG-I
T4126 3367-3373 Protein denotes Riplet
T4125 3351-3357 Protein denotes TRIM25
T4124 3264-3269 Protein denotes RIG-I
T4123 3153-3157 Protein denotes MAVS
T4122 2970-2976 Protein denotes Cardif
T4121 2964-2968 Protein denotes VISA
T4120 2957-2962 Protein denotes IPS-1
T4119 2939-2943 Protein denotes MAVS
T4118 2895-2900 Protein denotes RIG-I
T4117 2723-2728 Protein denotes RIG-I
T4116 2472-2476 Protein denotes TLR3
T4115 2401-2406 Protein denotes RIG-I
T4114 2355-2360 Protein denotes RIG-I
T4113 2145-2150 Protein denotes RIG-I
T4112 2136-2140 Protein denotes TLR3
T4111 1196-1201 Protein denotes IFI16
T4110 1173-1177 Protein denotes AIM2
T4109 1124-1127 Protein denotes DAI
T4108 1118-1122 Protein denotes TLR9
T4107 967-971 Protein denotes TLR7
T4106 1022-1026 Protein denotes MDA5
T4105 1015-1020 Protein denotes RIG-I
T4104 1009-1013 Protein denotes TLR3
T4103 979-983 Protein denotes Nod2
T4102 973-977 Protein denotes TLR8
T4101 603-607 Protein denotes IRF7
T4100 594-598 Protein denotes IRF3
T4099 471-476 Protein denotes IFN-β
T4098 460-465 Protein denotes IFN-α
T4097 446-458 Protein denotes interferon-α
T4096 416-420 Protein denotes IL-1
T4095 407-411 Protein denotes IL-6
T4094 402-405 Protein denotes TNF
R3057 T4115 T4153 themeOf RIG-I,deficient
R3062 T4116 T4152 themeOf TLR3,deficient
R3063 T4118 T4154 themeOf RIG-I,associate
R3070 T4119 T4154 themeOf MAVS,associate
R3072 T4122 T4155 themeOf Cardif,translocates
R3075 T4127 T4157 themeOf RIG-I,activation
R3082 T4130 T4158 themeOf IRF3,activation
R3090 T4150 T4151 themeOf production,induces
R3091 T4150 T4151 themeOf production,induces
R3093 T4150 T4151 themeOf production,induces
R3097 T4157 T4156 themeOf activation,promote
R3039 T4094 T4150 themeOf TNF,production
R3049 T4095 T4150 themeOf IL-6,production
R3053 T4096 T4150 themeOf IL-1,production
R3054 T4097 T4150 themeOf interferon-α,production
R3055 T4098 T4150 themeOf IFN-α,production
R3056 T4099 T4150 themeOf IFN-β,production
R3085 T4137 T4159 themeOf MAVS,degradation
R3086 T4139 T4160 themeOf IRF3,attachment
R3087 T4140 T4160 themeOf IRF7,attachment
R3088 T4142 T4160 themeOf TRIM21,attachment
R3089 T4143 T4160 themeOf RBCK1,attachment
R3094 T4150 T4151 themeOf production,induces
R3095 T4150 T4151 themeOf production,induces
R3096 T4150 T4151 themeOf production,induces

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T3750 4071-4081 Binding denotes attachment
T3749 3994-4005 Protein_catabolism denotes degradation
T3748 3985-3993 Positive_regulation denotes mediated
T3747 3566-3576 Positive_regulation denotes activation
T3746 3414-3421 Positive_regulation denotes promote
T3745 3428-3438 Positive_regulation denotes activation
T3744 3014-3026 Localization denotes translocates
T3743 2901-2910 Binding denotes associate
T3742 2477-2486 Negative_regulation denotes deficient
T3741 2407-2416 Negative_regulation denotes deficient
T3740 339-346 Positive_regulation denotes induces
T3739 351-361 Gene_expression denotes production
T3738 5669-5674 Protein denotes IRF-3
T3737 5633-5637 Protein denotes TLR3
T3736 5622-5627 Protein denotes RIG-I
T3735 4673-4678 Protein denotes IL-1R
T3734 4658-4662 Protein denotes TLR4
T3733 4632-4646 Protein denotes TNF receptor I
T3732 4204-4209 Protein denotes RBCK1
T3731 4188-4194 Protein denotes TRIM21
T3730 4177-4181 Protein denotes RAUL
T3729 4135-4139 Protein denotes IRF7
T3728 4126-4130 Protein denotes IRF3
T3727 3964-3969 Protein denotes TRAF3
T3726 3955-3959 Protein denotes MAVS
T3725 3924-3931 Protein denotes TRIAD3A
T3724 3910-3914 Protein denotes AIP4
T3723 3744-3747 Protein denotes RLR
T3722 3672-3676 Protein denotes CYLD
T3721 3661-3665 Protein denotes DUBA
T3720 3582-3587 Protein denotes RIG-I
T3719 3561-3565 Protein denotes IRF3
T3718 3519-3524 Protein denotes TRAF3
T3717 3498-3503 Protein denotes TRAF6
T3716 3422-3427 Protein denotes RIG-I
T3715 3367-3373 Protein denotes Riplet
T3714 3351-3357 Protein denotes TRIM25
T3713 3264-3269 Protein denotes RIG-I
T3712 3153-3157 Protein denotes MAVS
T3711 2970-2976 Protein denotes Cardif
T3710 2964-2968 Protein denotes VISA
T3709 2957-2962 Protein denotes IPS-1
T3708 2939-2943 Protein denotes MAVS
T3707 2895-2900 Protein denotes RIG-I
T3706 2723-2728 Protein denotes RIG-I
T3705 2472-2476 Protein denotes TLR3
T3704 2401-2406 Protein denotes RIG-I
T3703 2355-2360 Protein denotes RIG-I
T3702 2145-2150 Protein denotes RIG-I
T3701 2136-2140 Protein denotes TLR3
T3700 1196-1201 Protein denotes IFI16
T3699 1173-1177 Protein denotes AIM2
T3684 407-411 Protein denotes IL-6
T3683 402-405 Protein denotes TNF
T3698 1124-1127 Protein denotes DAI
T3697 1118-1122 Protein denotes TLR9
T3696 967-971 Protein denotes TLR7
T3695 1022-1026 Protein denotes MDA5
T3694 1015-1020 Protein denotes RIG-I
T3693 1009-1013 Protein denotes TLR3
T3692 979-983 Protein denotes Nod2
T3691 973-977 Protein denotes TLR8
T3690 603-607 Protein denotes IRF7
T3689 594-598 Protein denotes IRF3
T3688 471-476 Protein denotes IFN-β
T3687 460-465 Protein denotes IFN-α
T3686 446-458 Protein denotes interferon-α
T3685 416-420 Protein denotes IL-1
R2932 T3683 T3739 themeOf TNF,production
R2933 T3684 T3739 themeOf IL-6,production
R2935 T3687 T3739 themeOf IFN-α,production
R2936 T3688 T3739 themeOf IFN-β,production
R2961 T3726 T3749 themeOf MAVS,degradation
R2966 T3728 T3750 themeOf IRF3,attachment
R2967 T3729 T3750 themeOf IRF7,attachment
R2968 T3730 T3750 themeOf RAUL,attachment
R2969 T3731 T3750 themeOf TRIM21,attachment
R2971 T3732 T3750 themeOf RBCK1,attachment
R2991 T3749 T3748 themeOf degradation,mediated
R2931 T3685 T3739 themeOf IL-1,production
R2934 T3686 T3739 themeOf interferon-α,production
R2937 T3704 T3741 themeOf RIG-I,deficient
R2944 T3705 T3742 themeOf TLR3,deficient
R2945 T3707 T3743 themeOf RIG-I,associate
R2947 T3711 T3744 themeOf Cardif,translocates
R2952 T3716 T3745 themeOf RIG-I,activation
R2956 T3719 T3747 themeOf IRF3,activation
R2979 T3739 T3740 themeOf production,induces
R2983 T3739 T3740 themeOf production,induces
R2984 T3739 T3740 themeOf production,induces
R2987 T3739 T3740 themeOf production,induces
R2988 T3739 T3740 themeOf production,induces
R2989 T3739 T3740 themeOf production,induces
R2990 T3745 T3746 themeOf activation,promote

DLUT931

Id Subject Object Predicate Lexical cue
T3821 5613-5621 Regulation denotes regulate
T3820 3985-3993 Positive_regulation denotes mediated
T3819 3994-4005 Protein_catabolism denotes degradation
T3818 3735-3743 Negative_regulation denotes regulate
T3817 3530-3537 Positive_regulation denotes mediate
T3816 3566-3576 Positive_regulation denotes activation
T3815 3428-3438 Positive_regulation denotes activation
T3814 3255-3263 Regulation denotes regulate
T3813 3270-3278 Positive_regulation denotes mediated
T3812 3014-3026 Localization denotes translocates
T3811 2901-2910 Binding denotes associate
T3810 2407-2416 Negative_regulation denotes deficient
T3809 2361-2369 Positive_regulation denotes mediated
T3808 339-346 Positive_regulation denotes induces
T3807 351-361 Gene_expression denotes production
T3806 5669-5674 Protein denotes IRF-3
T3805 5633-5637 Protein denotes TLR3
T3804 5622-5627 Protein denotes RIG-I
T3803 4673-4678 Protein denotes IL-1R
T3802 4658-4662 Protein denotes TLR4
T3801 4632-4646 Protein denotes TNF receptor I
T3800 4204-4209 Protein denotes RBCK1
T3799 4188-4194 Protein denotes TRIM21
T3798 4177-4181 Protein denotes RAUL
T3797 4135-4139 Protein denotes IRF7
T3796 4126-4130 Protein denotes IRF3
T3795 3964-3969 Protein denotes TRAF3
T3794 3955-3959 Protein denotes MAVS
T3793 3924-3931 Protein denotes TRIAD3A
T3792 3910-3914 Protein denotes AIP4
T3791 3744-3747 Protein denotes RLR
T3790 3672-3676 Protein denotes CYLD
T3789 3661-3665 Protein denotes DUBA
T3758 603-607 Protein denotes IRF7
T3757 594-598 Protein denotes IRF3
T3756 471-476 Protein denotes IFN-β
T3755 460-465 Protein denotes IFN-α
T3754 446-458 Protein denotes interferon-α
T3753 416-420 Protein denotes IL-1
T3752 407-411 Protein denotes IL-6
T3751 402-405 Protein denotes TNF
T3788 3582-3587 Protein denotes RIG-I
T3787 3561-3565 Protein denotes IRF3
T3786 3519-3524 Protein denotes TRAF3
T3785 3498-3503 Protein denotes TRAF6
T3784 3422-3427 Protein denotes RIG-I
T3783 3367-3373 Protein denotes Riplet
T3782 3351-3357 Protein denotes TRIM25
T3781 3264-3269 Protein denotes RIG-I
T3780 3153-3157 Protein denotes MAVS
T3779 2970-2976 Protein denotes Cardif
T3778 2964-2968 Protein denotes VISA
T3777 2957-2962 Protein denotes IPS-1
T3776 2939-2943 Protein denotes MAVS
T3775 2895-2900 Protein denotes RIG-I
T3774 2723-2728 Protein denotes RIG-I
T3773 2472-2476 Protein denotes TLR3
T3772 2401-2406 Protein denotes RIG-I
T3771 2355-2360 Protein denotes RIG-I
T3770 2145-2150 Protein denotes RIG-I
T3769 2136-2140 Protein denotes TLR3
T3768 1196-1201 Protein denotes IFI16
T3767 1173-1177 Protein denotes AIM2
T3766 1124-1127 Protein denotes DAI
T3765 1118-1122 Protein denotes TLR9
T3764 967-971 Protein denotes TLR7
T3763 1022-1026 Protein denotes MDA5
T3762 1015-1020 Protein denotes RIG-I
T3761 1009-1013 Protein denotes TLR3
T3760 979-983 Protein denotes Nod2
T3759 973-977 Protein denotes TLR8
R2965 T3795 T3819 themeOf TRAF3,degradation
R2970 T3804 T3821 themeOf RIG-I,regulate
R2972 T3806 T3821 causeOf IRF-3,regulate
R2974 T3807 T3808 themeOf production,induces
R2975 T3807 T3808 themeOf production,induces
R2976 T3807 T3808 themeOf production,induces
R2977 T3807 T3808 themeOf production,induces
R2978 T3807 T3808 themeOf production,induces
R2980 T3813 T3814 themeOf mediated,regulate
R2981 T3816 T3817 themeOf activation,mediate
R2982 T3816 T3817 themeOf activation,mediate
R2985 T3819 T3820 themeOf degradation,mediated
R2986 T3819 T3820 themeOf degradation,mediated
R2938 T3751 T3807 themeOf TNF,production
R2946 T3771 T3809 themeOf RIG-I,mediated
R2948 T3772 T3810 themeOf RIG-I,deficient
R2949 T3775 T3811 themeOf RIG-I,associate
R2950 T3776 T3811 themeOf MAVS,associate
R2951 T3777 T3812 themeOf IPS-1,translocates
R2973 T3807 T3808 themeOf production,induces
R2939 T3752 T3807 themeOf IL-6,production
R2940 T3753 T3807 themeOf IL-1,production
R2941 T3754 T3807 themeOf interferon-α,production
R2942 T3755 T3807 themeOf IFN-α,production
R2943 T3756 T3807 themeOf IFN-β,production
R2953 T3778 T3812 themeOf VISA,translocates
R2954 T3779 T3812 themeOf Cardif,translocates
R2955 T3781 T3813 themeOf RIG-I,mediated
R2957 T3784 T3815 themeOf RIG-I,activation
R2958 T3785 T3817 causeOf TRAF6,mediate
R2959 T3786 T3817 causeOf TRAF3,mediate
R2960 T3787 T3816 themeOf IRF3,activation
R2962 T3789 T3818 causeOf DUBA,regulate
R2963 T3791 T3818 themeOf RLR,regulate
R2964 T3794 T3819 themeOf MAVS,degradation

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue
T4360 2859-2874 Binding denotes ligand binding,
T4359 762-796 Localization denotes by specific intracellular PRRs [3]
T4358 3744-3757 Positive_regulation denotes RLR signaling
T4357 3661-3819 Regulation denotes DUBA [28], CYLD [29], [30] and OTUB1/2 [31] have been shown to negatively regulate RLR signaling by specifically removing K63-linked polyubiquitin chains from
T4356 6286-6307 Gene_expression denotes chemokine production,
T4355 3561-3576 Positive_regulation denotes IRF3 activation
T4354 4007-4051 Negative_regulation denotes thus inhibiting further downstream signaling
T4353 1466-1506 Gene_expression denotes the production of antiviral proteins [9]
T4352 6239-6281 Binding denotes mice is associated with increased cytokine
T4351 3942-4006 Regulation denotes respectively MAVS and TRAF3 for proteasome mediated degradation,
T4350 3942-4006 Regulation denotes respectively MAVS and TRAF3 for proteasome mediated degradation,
T4349 320-338 Positive_regulation denotes Triggering of PRRs
T4348 2355-2369 Regulation denotes RIG-I mediated
T4347 3582-3599 Positive_regulation denotes RIG-I stimulation
T4346 3422-3438 Positive_regulation denotes RIG-I activation
T4345 2352-2384 Positive_regulation denotes on RIG-I mediated signaling [13]
T4344 4874-4918 Localization denotes gene targeting of A20 in specific cell types
T4343 762-796 Protein denotes by specific intracellular PRRs [3]
T4342 1136-1177 Entity denotes the PYHIN domain containing proteins AIM2
T4341 3472-3481 Entity denotes ubiquitin
T4340 3672-3687 Protein denotes CYLD [29], [30]
T4339 4204-4209 Protein denotes RBCK1
T4338 603-616 Protein denotes IRF7 [1], [2]
T4337 3883-3909 Protein denotes ubiquitin ligases, such as
T4336 4119-4167 Protein denotes to the IRF3 and IRF7 transcription factors by E3
T4335 152-161 Entity denotes antiviral
T4334 594-598 Protein denotes IRF3
T4333 4262-4265 Protein denotes A20
T4332 3661-3670 Protein denotes DUBA [28]
T4331 3964-3984 Protein denotes TRAF3 for proteasome
T4330 2738-2777 Entity denotes a C-terminal DExD/H box helicase domain
T4329 798-827 Protein denotes Endosomal Toll-like receptors
T4328 3519-3529 Protein denotes TRAF3 [27]
T4327 3082-3096 Entity denotes its C-terminal
T4326 3924-3936 Protein denotes TRIAD3A [33]
T4325 2825-2839 Entity denotes two N-terminal
T4324 6376-6397 Entity denotes alveolar macrophages,
T4323 6340-6360 Entity denotes immune cells such as
T4322 3453-3514 Protein denotes well characterized ubiquitin ligases such as TRAF6 [25], [26]
T4321 979-983 Protein denotes Nod2
T4320 870-884 Protein denotes like receptors
T4319 6090-6094 Protein denotes mice
T4318 3974-3984 Entity denotes proteasome
T4317 3582-3587 Protein denotes RIG-I
T4316 4889-4895 Protein denotes of A20
T4315 588-592 Protein denotes AP-1
T4314 2964-2968 Protein denotes VISA
T4313 3838-3847 Entity denotes molecules
T4312 1450-1453 Entity denotes DNA
T4311 1291-1325 Entity denotes plasmacytoid dendritic cells (pDC)
T4310 1124-1131 Protein denotes DAI [4]
T4309 4356-4359 Protein denotes A20
T4308 4335-4339 Protein denotes DUBs
T4307 5793-5814 Entity denotes myeloid cell specific
T4306 244-247 Protein denotes PRR
T4305 1442-1445 Protein denotes RNA
T4304 4404-4416 Entity denotes K48-specific
T4303 2211-2225 Protein denotes Both receptors
T4302 6051-6062 Entity denotes macrophages
T4301 5605-5608 Protein denotes A20
T4300 2935-2993 Protein denotes the MAVS (also termed IPS-1, VISA, Cardif) adaptor protein
T4299 3646-3650 Protein denotes DUBs
T4298 895-920 Protein denotes Nod-like receptors (NLRs)
T4297 3264-3269 Protein denotes RIG-I
T4296 2401-2406 Protein denotes RIG-I
T4295 4430-4436 Protein denotes ligase
T4294 6028-6037 Entity denotes antiviral
T4293 663-672 Protein denotes viral RNA
T4292 4085-4097 Entity denotes K48-specific
T4291 1004-1027 Protein denotes RNA (TLR3, RIG-I, MDA5)
T4290 5622-5628 Protein denotes RIG-I-
T4289 6183-6200 Protein denotes to wild type mice
T4288 3189-3198 Protein denotes ubiquitin
T4287 3305-3317 Entity denotes K63-specific
T4286 4658-4668 Protein denotes TLR4 [40],
T4285 3783-3793 Entity denotes K63-linked
T4284 6511-6514 Protein denotes A20
T4283 3794-3807 Protein denotes polyubiquitin
T4282 4712-4718 Protein denotes of A20
T4281 1196-1205 Protein denotes IFI16 [8]
T4280 3045-3077 Entity denotes the outer mitochondrial membrane
T4279 2762-2770 Protein denotes helicase
T4278 967-972 Protein denotes TLR7,
T4277 1389-1400 Entity denotes macrophages
T4276 1136-1177 Protein denotes the PYHIN domain containing proteins AIM2
T4275 6239-6243 Protein denotes mice
T4274 6258-6281 Protein denotes with increased cytokine
T4273 446-466 Protein denotes interferon-α (IFN-α)
T4272 407-411 Protein denotes IL-6
T4271 4310-4317 Protein denotes the OTU
T4270 4177-4186 Protein denotes RAUL [34]
T4269 5669-5674 Protein denotes IRF-3
T4268 2098-2134 Entity denotes an intermediate of viral replication
T4267 1068-1094 Entity denotes antiviral immune responses
T4266 4231-4240 Entity denotes antiviral
T4265 5793-5832 Protein denotes myeloid cell specific A20 knockout mice
T4264 3482-3497 Protein denotes ligases such as
T4263 3744-3747 Protein denotes RLR
T4262 4382-4386 Entity denotes zinc
T4261 331-338 Protein denotes of PRRs
T4260 2825-2852 Entity denotes two N-terminal CARD domains
T4259 2859-2865 Entity denotes ligand
T4258 2884-2900 Entity denotes domains of RIG-I
T4257 4874-4878 Protein denotes gene
T4256 5409-5415 Protein denotes of A20
T4255 1366-1387 Protein denotes conventional DC (cDC)
T4254 187-249 Protein denotes the action of specialized pattern recognition receptors (PRR),
T4253 774-787 Entity denotes intracellular
T4252 677-747 Entity denotes DNA, viral replication intermediates and viral transcription products,
T4251 2028-2055 Protein denotes single-stranded genomic RNA
T4250 2011-2080 Entity denotes the host cell of single-stranded genomic RNA and double stranded RNA,
T4249 1845-1854 Entity denotes antiviral
T4248 915-919 Protein denotes NLRs
T4247 5434-5463 Entity denotes of antiviral immune responses
T4246 2801-2807 Entity denotes ligand
T4245 864-891 Protein denotes RIG-I-like receptors (RLRs)
T4244 5815-5818 Protein denotes A20
T4243 3422-3427 Protein denotes RIG-I
T4242 1321-1324 Protein denotes pDC
T4241 2355-2369 Protein denotes RIG-I mediated
T4240 416-420 Protein denotes IL-1
T4239 1275-1326 Protein denotes I IFN producing plasmacytoid dendritic cells (pDC),
T4238 2957-2969 Protein denotes IPS-1, VISA,
T4237 4605-4651 Protein denotes multiple receptors such as TNF receptor I [37]
T4236 3351-3362 Protein denotes TRIM25 [22]
T4235 4605-4631 Protein denotes multiple receptors such as
T4234 6527-6540 Entity denotes myeloid cells
T4233 5026-5029 Protein denotes A20
T4232 2738-2777 Entity denotes a C-terminal DExD/H box helicase domain
T4231 895-920 Protein denotes Nod-like receptors (NLRs)
T4230 3318-3327 Protein denotes ubiquitin
T4229 1118-1122 Protein denotes TLR9
T4228 2957-2976 Protein denotes IPS-1, VISA, Cardif
T4227 2472-2476 Protein denotes TLR3
T4226 2723-2728 Protein denotes RIG-I
T4225 4269-4324 Entity denotes an ubiquitin-editing enzyme belonging to the OTU-domain
T4224 6286-6295 Protein denotes chemokine
T4223 864-891 Protein denotes RIG-I-like receptors (RLRs)
T4222 5633-5645 Protein denotes TLR3-induced
T4221 1484-1493 Entity denotes antiviral
T4220 74-90 Entity denotes on the host cell
T4219 581-586 Protein denotes NF-κB
T4218 2895-2900 Protein denotes RIG-I
T4217 402-405 Protein denotes TNF
T4216 1327-1348 Entity denotes while most other cell
T4215 1405-1416 Entity denotes fibroblasts
T4214 1098-1101 Entity denotes DNA
T4213 3955-3959 Protein denotes MAVS
T4212 1009-1026 Protein denotes TLR3, RIG-I, MDA5
T4211 2472-2491 Protein denotes TLR3 deficient mice
T4210 2136-2140 Protein denotes TLR3
T4209 2738-2777 Entity denotes a C-terminal DExD/H box helicase domain
T4208 4673-4678 Protein denotes IL-1R
T4207 386-421 Protein denotes cytokines (e.g. TNF, IL-6 and IL-1)
T4206 1009-1021 Protein denotes TLR3, RIG-I,
T4205 3692-3704 Protein denotes OTUB1/2 [31]
T4204 4685-4718 Entity denotes The anti-inflammatory role of A20
T4171 3153-3157 Protein denotes MAVS
T4170 4373-4429 Protein denotes atypical zinc finger dependent K48-specific E3 ubiquitin
T4169 471-476 Protein denotes IFN-β
T4168 967-984 Protein denotes TLR7, TLR8, Nod2)
T4167 5213-5216 Protein denotes A20
T4166 2145-2150 Protein denotes RIG-I
T4165 1043-1046 Entity denotes DNA
T4164 4760-4778 Protein denotes A20 deficient mice
T4163 4899-4918 Entity denotes specific cell types
T4162 3305-3335 Protein denotes K63-specific ubiquitin ligases
T4161 4126-4130 Protein denotes IRF3
T4203 3561-3565 Protein denotes IRF3
T4202 5659-5664 Protein denotes NF-κB
T4201 4290-4296 Protein denotes enzyme
T4200 4586-4589 Protein denotes A20
T4199 886-890 Protein denotes RLRs
T4198 1383-1386 Entity denotes cDC
T4197 1029-1109 Entity denotes Intracellular DNA sensors that mediate antiviral immune responses to DNA viruses
T4196 3870-3882 Entity denotes K48-specific
T4195 2296-2335 Entity denotes of the innate antiviral immune response
T4194 1481-1502 Protein denotes of antiviral proteins
T4193 4135-4139 Protein denotes IRF7
T4192 899-913 Protein denotes like receptors
T4191 3178-3217 Protein denotes of various ubiquitin modifying enzymes,
T4190 1015-1020 Protein denotes RIG-I
T4189 3883-3892 Protein denotes ubiquitin
T4188 1136-1177 Protein denotes the PYHIN domain containing proteins AIM2
T4187 3367-3373 Protein denotes Riplet
T4186 2649-2664 Entity denotes by immune cells
T4185 433-477 Protein denotes interferons (interferon-α (IFN-α) and IFN-β)
T4184 839-943 Protein denotes cytoplasmic RNA helicase RIG-I-like receptors (RLRs) or Nod-like receptors (NLRs) detect the presence of
T4183 3910-3919 Protein denotes AIP4 [32]
T4182 460-465 Protein denotes IFN-α
T4181 5957-5960 Protein denotes A20
T4180 2401-2421 Protein denotes RIG-I deficient mice
T4179 3551-3556 Protein denotes NF-κB
T4178 4188-4199 Protein denotes TRIM21 [35]
T4177 631-654 Entity denotes of viral nucleic acids,
T4176 4098-4111 Protein denotes polyubiquitin
T4175 2911-2931 Entity denotes with the CARD domain
T4174 2939-2977 Protein denotes MAVS (also termed IPS-1, VISA, Cardif)
T4173 5720-5726 Protein denotes of A20
T4172 4760-4763 Protein denotes A20
R3108 T4253 T4359 locationOf intracellular,by specific intracellular PRRs [3]
R3109 T4343 T4359 themeOf by specific intracellular PRRs [3],by specific intracellular PRRs [3]
R3111 T4263 T4358 causeOf RLR,RLR signaling
R3112 T4358 T4357 themeOf RLR signaling,"DUBA [28], CYLD [29], [30] and OTUB1/2 [31] have been shown to negatively regulate RLR signaling by specifically removing K63-linked polyubiquitin chains from"
R3092 T4163 T4344 locationOf specific cell types,gene targeting of A20 in specific cell types
R3098 T4203 T4355 themeOf IRF3,IRF3 activation
R3099 T4213 T4350 causeOf MAVS,"respectively MAVS and TRAF3 for proteasome mediated degradation,"
R3100 T4194 T4353 themeOf of antiviral proteins,the production of antiviral proteins [9]
R3101 T4224 T4356 themeOf chemokine,"chemokine production,"
R3102 T4241 T4345 causeOf RIG-I mediated,on RIG-I mediated signaling [13]
R3103 T4316 T4344 themeOf of A20,gene targeting of A20 in specific cell types
R3104 T4317 T4347 themeOf RIG-I,RIG-I stimulation
R3105 T4331 T4351 causeOf TRAF3 for proteasome,"respectively MAVS and TRAF3 for proteasome mediated degradation,"
R3106 T4241 T4348 themeOf RIG-I mediated,RIG-I mediated
R3107 T4243 T4346 themeOf RIG-I,RIG-I activation
R3110 T4261 T4349 themeOf of PRRs,Triggering of PRRs
R3113 T4274 T4352 themeOf with increased cytokine,mice is associated with increased cytokine
R3114 T4275 T4352 themeOf mice,mice is associated with increased cytokine

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T3612 6347-6352 NNS denotes cells
T3611 6340-6346 JJ denotes immune
T3610 6333-6339 NN denotes innate
T3609 6330-6332 IN denotes of
T3608 6318-6329 NN denotes recruitment
T3607 6308-6317 JJ denotes augmented
T3606 6306-6307 , denotes ,
T3605 6296-6306 NN denotes production
T3604 6286-6295 NN denotes chemokine
T3603 6282-6285 CC denotes and
T3602 6273-6281 NN denotes cytokine
T3601 6263-6272 VBN denotes increased
T3600 6258-6262 IN denotes with
T3599 6247-6257 VBN denotes associated
T3598 6244-6246 VBZ denotes is
T3597 6239-6243 NNS denotes mice
T3596 6228-6238 NNP denotes A20myel-KO
T3595 6225-6227 IN denotes in
T3594 6221-6224 NNP denotes IAV
T3593 6213-6220 IN denotes against
T3592 6202-6212 NN denotes Protection
T3591 6200-6201 . denotes .
T3590 6196-6200 NNS denotes mice
T3589 6191-6195 NN denotes type
T3588 6186-6190 JJ denotes wild
T3587 6183-6185 TO denotes to
T3586 6174-6182 VBN denotes compared
T3585 6164-6173 NN denotes infection
T3584 6159-6163 NN denotes lung
T3583 6155-6158 NNP denotes IAV
T3582 6152-6154 TO denotes to
T3581 6143-6151 NN denotes response
T3580 6140-6142 IN denotes in
T3579 6130-6139 NN denotes morbidity
T3578 6122-6129 VBD denotes reduced
T3577 6118-6121 CC denotes and
T3576 6109-6117 NN denotes survival
T3575 6100-6108 JJ denotes enhanced
T3574 6095-6099 VBP denotes show
T3573 6090-6094 NNS denotes mice
T3572 6079-6089 JJ denotes A20myel-KO
T3571 6077-6078 , denotes ,
T3570 6064-6077 RB denotes Interestingly
T3569 6062-6063 . denotes .
T3568 6051-6062 NNS denotes macrophages
T3567 6048-6050 IN denotes in
T3566 6038-6047 VBG denotes signaling
T3565 6028-6037 JJ denotes antiviral
T3564 6024-6027 CC denotes and
T3563 6008-6023 JJ denotes proinflammatory
T3562 5996-6007 JJ denotes IAV-induced
T3561 5993-5995 IN denotes of
T3560 5983-5992 NN denotes regulator
T3559 5974-5982 JJ denotes negative
T3558 5966-5973 JJ denotes crucial
T3557 5964-5965 DT denotes a
T3556 5961-5963 VBZ denotes is
T3555 5957-5960 NNP denotes A20
T3554 5952-5956 IN denotes that
T3553 5943-5951 NN denotes evidence
T3552 5935-5942 VBP denotes provide
T3551 5930-5934 RB denotes here
T3550 5927-5929 PRP denotes we
T3549 5925-5926 , denotes ,
T3548 5921-5925 NNS denotes mice
T3547 5915-5920 DT denotes these
T3546 5912-5914 IN denotes of
T3545 5904-5911 VBN denotes derived
T3544 5898-5903 NNS denotes cells
T3543 5890-5897 JJ denotes primary
T3542 5886-5889 CC denotes and
T3541 5882-5885 NN denotes lab
T3490 5627-5628 : denotes -
T3489 5622-5627 NNP denotes RIG-I
T3488 5613-5621 VB denotes regulate
T3487 5609-5612 MD denotes may
T3486 5605-5608 NNP denotes A20
T3485 5600-5604 IN denotes that
T3484 5589-5599 VBG denotes indicating
T3483 5587-5588 , denotes ,
T3482 5582-5587 NNS denotes lines
T3481 5577-5581 NN denotes cell
T3480 5568-5576 JJ denotes specific
T3479 5565-5567 IN denotes in
T3478 5555-5564 VBG denotes silencing
T3477 5552-5554 CC denotes or
T3476 5537-5551 NN denotes overexpression
T3475 5531-5536 VBG denotes using
T3474 5523-5530 NNS denotes studies
T3473 5517-5522 NN denotes vitro
T3472 5514-5516 IN denotes in
T3471 5511-5513 IN denotes of
T3470 5504-5510 NN denotes number
T3469 5502-5503 DT denotes a
T3468 5499-5501 TO denotes to
T3467 5491-5498 VBN denotes limited
T3466 5487-5490 CC denotes and
T3465 5477-5486 VBN denotes described
T3464 5472-5476 RB denotes well
T3463 5467-5471 RBR denotes less
T3462 5464-5466 VBZ denotes is
T3461 5454-5463 NNS denotes responses
T3460 5447-5453 JJ denotes immune
T3459 5437-5446 JJ denotes antiviral
T3458 5434-5436 IN denotes of
T3457 5423-5433 NN denotes regulation
T3456 5419-5422 DT denotes the
T3455 5416-5418 IN denotes in
T3454 5412-5415 NNP denotes A20
T3453 5409-5411 IN denotes of
T3452 5404-5408 NN denotes role
T3451 5400-5403 DT denotes the
T3450 5398-5399 , denotes ,
T3449 5389-5398 NNS denotes responses
T3448 5373-5388 JJ denotes proinflammatory
T3447 5370-5372 IN denotes of
T3446 5359-5369 NN denotes regulation
T3445 5355-5358 DT denotes the
T3444 5352-5354 IN denotes in
T3443 5343-5351 NN denotes function
T3442 5331-5342 VBN denotes established
T3441 5326-5330 RB denotes well
T3440 5322-5325 PRP$ denotes its
T3439 5319-5321 TO denotes to
T3438 5310-5318 NN denotes contrast
T3437 5307-5309 IN denotes In
T3436 5305-5306 . denotes .
T3435 5304-5305 NNP denotes ]
T3434 5302-5304 CD denotes 45
T3433 5301-5302 NNP denotes [
T3432 5288-5300 NN denotes inflammation
T3431 5280-5287 JJ denotes chronic
T3430 5276-5279 CC denotes and
T3429 5267-5275 NNS denotes diseases
T3428 5256-5266 JJ denotes autoimmune
T3427 5248-5255 JJ denotes several
T3426 5243-5247 IN denotes with
T3425 5232-5242 VBN denotes associated
T3424 5228-5231 VBP denotes are
T3423 5223-5227 WDT denotes that
T3422 5217-5222 NN denotes locus
T3421 5213-5216 NNP denotes A20
T3420 5209-5212 DT denotes the
T3419 5206-5208 IN denotes in
T3418 5192-5205 NNS denotes polymorphisms
T3417 5189-5191 IN denotes of
T3416 5174-5188 NN denotes identification
T3415 5170-5173 DT denotes the
T3414 5162-5169 IN denotes through
T3413 5150-5161 VBN denotes illustrated
T3412 5145-5149 VBN denotes been
T3411 5136-5144 RB denotes recently
T3410 5132-5135 VBZ denotes has
T3409 5124-5131 NN denotes disease
T3408 5118-5123 JJ denotes human
T3407 5114-5117 IN denotes for
T3406 5105-5113 NNS denotes findings
T3405 5099-5104 DT denotes these
T3404 5096-5098 IN denotes of
T3403 5086-5095 NN denotes relevance
T3402 5082-5085 DT denotes The
T3401 5080-5081 . denotes .
T3400 5072-5080 NN denotes response
T3399 5059-5071 JJ denotes inflammatory
T3398 5055-5058 DT denotes the
T3397 5052-5054 IN denotes on
T3396 5046-5051 NN denotes brake
T3395 5036-5045 JJ denotes important
T3394 5033-5035 DT denotes an
T3393 5030-5032 VBZ denotes is
T3392 5026-5029 NNP denotes A20
T3391 5021-5025 IN denotes that
T3390 5008-5020 VBG denotes illustrating
T3389 5000-5007 JJ denotes further
T3388 4998-4999 , denotes ,
T3387 4997-4998 NNP denotes ]
T3386 4995-4997 CD denotes 48
T3385 4994-4995 NNP denotes [
T3384 4992-4993 NNP denotes ]
T3383 4990-4992 CD denotes 42
T3382 4989-4990 NNP denotes [
T3381 4976-4988 NN denotes inflammation
T3380 4968-4975 JJ denotes chronic
T3379 4964-4967 CC denotes and
T3378 4951-4963 NN denotes autoimmunity
T3377 4946-4950 IN denotes with
T3376 4935-4945 VBN denotes associated
T3375 4932-4934 VB denotes be
T3374 4929-4931 TO denotes to
T3373 4923-4928 VBN denotes shown
T3372 4919-4922 VBD denotes was
T3371 4913-4918 NNS denotes types
T3370 4908-4912 NN denotes cell
T3369 4899-4907 JJ denotes specific
T3368 4896-4898 IN denotes in
T3367 4892-4895 NNP denotes A20
T3366 4889-4891 IN denotes of
T3365 4879-4888 VBG denotes targeting
T3364 4874-4878 NN denotes gene
T3363 4872-4873 , denotes ,
T3362 4864-4872 RB denotes recently
T3361 4859-4863 RBR denotes More
T3360 4857-4858 . denotes .
T3359 4856-4857 NNP denotes ]
T3358 4854-4856 CD denotes 37
T3357 4853-4854 NNP denotes [
T3356 4844-4852 NN denotes cachexia
T3355 4840-4843 CC denotes and
T3354 4827-4839 NN denotes inflammation
T3353 4815-4826 JJ denotes multi-organ
T3352 4808-4814 JJ denotes severe
T3351 4805-4807 TO denotes to
T3350 4801-4804 JJ denotes due
T3349 4795-4800 NN denotes birth
T3348 4789-4794 IN denotes after
T3347 4783-4788 RB denotes early
T3346 4779-4782 VBP denotes die
T3345 4774-4778 NNS denotes mice
T3344 4764-4773 JJ denotes deficient
T3343 4760-4763 CD denotes A20
T3342 4755-4759 IN denotes that
T3341 4750-4754 NN denotes fact
T3340 4746-4749 DT denotes the
T3339 4743-4745 IN denotes by
T3338 4730-4742 VBN denotes demonstrated
T3337 4722-4729 RB denotes clearly
T3336 4719-4721 VBZ denotes is
T3335 4715-4718 NNP denotes A20
T3334 4712-4714 IN denotes of
T3333 4707-4711 NN denotes role
T3332 4689-4706 JJ denotes anti-inflammatory
T3331 4685-4688 DT denotes The
T3330 4683-4684 . denotes .
T3329 4682-4683 NNP denotes ]
T3328 4680-4682 CD denotes 41
T3327 4679-4680 NNP denotes [
T3326 4673-4678 NNP denotes IL-1R
T3325 4669-4672 CC denotes and
T3324 4667-4668 , denotes ,
T3323 4666-4667 NNP denotes ]
T3322 4664-4666 CD denotes 40
T3321 4663-4664 NNP denotes [
T3320 4658-4662 CD denotes TLR4
T3319 4656-4657 , denotes ,
T3318 4655-4656 NNP denotes ]
T3317 4653-4655 CD denotes 39
T3316 4652-4653 NNP denotes [
T3315 4650-4651 NNP denotes ]
T3314 4648-4650 CD denotes 37
T3313 4647-4648 VBP denotes [
T3312 4645-4646 PRP denotes I
T3311 4636-4644 NN denotes receptor
T3310 4632-4635 NNP denotes TNF
T3309 4629-4631 IN denotes as
T3308 4624-4628 JJ denotes such
T3307 4614-4623 NNS denotes receptors
T3306 4605-4613 JJ denotes multiple
T3305 4602-4604 TO denotes to
T3304 4593-4601 NN denotes response
T3303 4590-4592 IN denotes in
T3302 4586-4589 NNP denotes A20
T3301 4583-4585 IN denotes by
T3300 4573-4582 VBG denotes signaling
T3299 4557-4572 JJ denotes proinflammatory
T3298 4554-4556 IN denotes of
T3297 4543-4553 NN denotes regulation
T3296 4534-4542 JJ denotes negative
T3295 4530-4533 DT denotes the
T3294 4527-4529 IN denotes in
T3293 4518-4526 VBN denotes involved
T3292 4515-4517 VB denotes be
T3291 4512-4514 TO denotes to
T3290 4506-4511 VBN denotes shown
T3289 4495-4505 RB denotes previously
T3288 4490-4494 VBD denotes were
T3287 4479-4489 NNS denotes mechanisms
T3286 4466-4478 JJ denotes noncatalytic
T3285 4462-4465 CC denotes and
T3284 4452-4461 JJ denotes catalytic
T3283 4447-4451 DT denotes Both
T3282 4445-4446 . denotes .
T3281 4437-4445 NN denotes activity
T3280 4430-4436 NN denotes ligase
T3279 4420-4429 NN denotes ubiquitin
T3278 4417-4419 NN denotes E3
T3277 4404-4416 JJ denotes K48-specific
T3276 4394-4403 JJ denotes dependent
T3275 4387-4393 NN denotes finger
T3063 3286-3298 NN denotes transduction
T3062 3279-3285 NN denotes signal
T3061 3270-3278 VBD denotes mediated
T3060 3264-3269 NNP denotes RIG-I
T3059 3255-3263 VB denotes regulate
T3058 3244-3254 RB denotes negatively
T3057 3240-3243 CC denotes and
T3056 3229-3239 RB denotes positively
T3055 3224-3228 DT denotes both
T3054 3218-3223 WDT denotes which
T3053 3216-3217 , denotes ,
T3052 3209-3216 NNS denotes enzymes
T3051 3199-3208 VBG denotes modifying
T3050 3189-3198 NN denotes ubiquitin
T3049 3181-3188 JJ denotes various
T3048 3178-3180 IN denotes of
T3047 3171-3177 NN denotes action
T3046 3167-3170 DT denotes the
T3045 3158-3166 VBZ denotes requires
T3044 3153-3157 NNP denotes MAVS
T3043 3150-3152 IN denotes of
T3042 3139-3149 JJ denotes downstream
T3041 3129-3138 VBG denotes Signaling
T3040 3127-3128 . denotes .
T3039 3126-3127 NNP denotes ]
T3038 3124-3126 CD denotes 20
T3037 3123-3124 NNP denotes [
T3036 3121-3122 NNP denotes ]
T3035 3119-3121 CD denotes 17
T3034 3118-3119 NNP denotes [
T3033 3111-3117 NN denotes domain
T3032 3097-3110 NN denotes transmembrane
T3031 3086-3096 JJ denotes C-terminal
T3030 3082-3085 PRP$ denotes its
T3029 3078-3081 IN denotes via
T3028 3069-3077 NN denotes membrane
T3027 3055-3068 JJ denotes mitochondrial
T3026 3049-3054 JJ denotes outer
T3025 3045-3048 DT denotes the
T3024 3042-3044 IN denotes in
T3023 3034-3041 NNS denotes inserts
T3022 3030-3033 CC denotes and
T3021 3027-3029 TO denotes to
T3020 3014-3026 VBZ denotes translocates
T3019 3001-3013 RB denotes subsequently
T3018 2995-3000 WDT denotes which
T3017 2993-2994 , denotes ,
T3016 2986-2993 NN denotes protein
T3015 2978-2985 NN denotes adaptor
T3014 2976-2977 -RRB- denotes )
T3013 2970-2976 NNP denotes Cardif
T3012 2968-2969 , denotes ,
T3011 2964-2968 NNP denotes VISA
T3010 2962-2963 , denotes ,
T3009 2957-2962 NNP denotes IPS-1
T3008 2950-2956 VBN denotes termed
T3007 2945-2949 RB denotes also
T3006 2944-2945 -LRB- denotes (
T3005 2939-2943 NNP denotes MAVS
T3004 2935-2938 DT denotes the
T3003 2932-2934 IN denotes of
T3002 2925-2931 NN denotes domain
T3001 2920-2924 NNP denotes CARD
T3000 2916-2919 DT denotes the
T2999 2911-2915 IN denotes with
T2998 2901-2910 NN denotes associate
T2997 2895-2900 NNP denotes RIG-I
T2996 2892-2894 IN denotes of
T2995 2884-2891 NNS denotes domains
T2994 2879-2883 NNP denotes CARD
T2993 2875-2878 DT denotes the
T2992 2873-2874 , denotes ,
T2991 2866-2873 JJ denotes binding
T2990 2859-2865 JJ denotes ligand
T2989 2854-2858 IN denotes Upon
T2988 2852-2853 . denotes .
T2987 2845-2852 NNS denotes domains
T2986 2840-2844 NNP denotes CARD
T2985 2829-2839 JJ denotes N-terminal
T2984 2825-2828 CD denotes two
T2983 2821-2824 CC denotes and
T2982 2819-2820 , denotes ,
T2981 2808-2819 NN denotes recognition
T2980 2801-2807 NN denotes ligand
T2979 2797-2800 IN denotes for
T2978 2788-2796 VBN denotes required
T2977 2785-2787 VBZ denotes is
T2976 2779-2784 WDT denotes which
T2975 2777-2778 , denotes ,
T2974 2771-2777 NN denotes domain
T2973 2762-2770 NN denotes helicase
T2972 2758-2761 NN denotes box
T2971 2751-2757 NNP denotes DExD/H
T2970 2740-2750 JJ denotes C-terminal
T2969 2738-2739 DT denotes a
T2968 2729-2737 VBZ denotes contains
T2967 2723-2728 NNP denotes RIG-I
T2966 2721-2722 . denotes .
T2965 2712-2721 NN denotes influenza
T2964 2709-2711 IN denotes of
T2963 2696-2708 NN denotes pathogenesis
T2962 2692-2695 DT denotes the
T2961 2689-2691 TO denotes to
T2960 2678-2688 VB denotes contribute
T2959 2675-2677 TO denotes to
T2958 2668-2674 JJ denotes likely
T2957 2665-2667 VBZ denotes is
T2956 2659-2664 NNS denotes cells
T2955 2652-2658 JJ denotes immune
T2954 2649-2651 IN denotes by
T2953 2640-2648 VBN denotes released
T2952 2630-2639 NNS denotes mediators
T2951 2627-2629 IN denotes of
T2950 2619-2626 NNS denotes effects
T2949 2611-2618 JJ denotes harmful
T2948 2607-2610 CC denotes and
T2947 2596-2606 JJ denotes beneficial
T2946 2592-2595 DT denotes the
T2945 2584-2591 IN denotes between
T2944 2574-2583 NN denotes imbalance
T2943 2571-2573 DT denotes an
T2942 2566-2570 IN denotes that
T2941 2557-2565 VBP denotes indicate
T2940 2549-2556 NNS denotes results
T2939 2543-2548 DT denotes These
T2938 2541-2542 . denotes .
T2937 2540-2541 NNP denotes ]
T2936 2538-2540 CD denotes 16
T2935 2537-2538 NNP denotes [
T2934 2527-2536 NN denotes infection
T2933 2521-2526 JJ denotes acute
T2932 2518-2520 TO denotes to
T2931 2508-2517 NN denotes advantage
T2930 2499-2507 NN denotes survival
T2929 2497-2498 DT denotes a
T2928 2492-2496 VBP denotes have
T2927 2487-2491 NNS denotes mice
T2926 2477-2486 JJ denotes deficient
T2925 2472-2476 CD denotes TLR3
T2924 2464-2471 IN denotes whereas
T2923 2462-2463 , denotes ,
T2922 2461-2462 NNP denotes ]
T2921 2459-2461 CD denotes 15
T2920 2458-2459 NNP denotes [
T2919 2456-2457 , denotes ,
T2918 2455-2456 NNP denotes ]
T2917 2453-2455 CD denotes 14
T2916 2452-2453 NNP denotes [
T2915 2448-2451 NNP denotes IAV
T2914 2445-2447 TO denotes to
T2913 2433-2444 JJ denotes susceptible
T2912 2426-2432 RB denotes highly
T2911 2422-2425 VBP denotes are
T2910 2417-2421 NNS denotes mice
T2909 2407-2416 NN denotes deficient
T2908 2401-2406 NNP denotes RIG-I
T2907 2399-2400 , denotes ,
T2906 2386-2399 RB denotes Interestingly
T2905 2384-2385 . denotes .
T2904 2383-2384 NNP denotes ]
T2903 2381-2383 CD denotes 13
T2902 2380-2381 NNP denotes [
T2901 2370-2379 VBG denotes signaling
T2900 2361-2369 VBD denotes mediated
T2899 2355-2360 NNP denotes RIG-I
T2898 2352-2354 IN denotes on
T2897 2344-2351 VBZ denotes depends
T2896 2336-2343 RB denotes largely
T2895 2327-2335 NN denotes response
T2894 2320-2326 JJ denotes immune
T2893 2310-2319 JJ denotes antiviral
T2892 2303-2309 NN denotes innate
T2891 2299-2302 DT denotes the
T2890 2296-2298 IN denotes of
T2889 2285-2295 NN denotes initiation
T2888 2281-2284 DT denotes the
T2887 2277-2280 CC denotes but
T2886 2275-2276 , denotes ,
T2885 2272-2275 NNP denotes IAV
T2884 2269-2271 TO denotes to
T2883 2260-2268 NN denotes response
T2882 2244-2259 JJ denotes proinflammatory
T2881 2240-2243 DT denotes the
T2880 2237-2239 TO denotes to
T2879 2226-2236 VBP denotes contribute
T2878 2216-2225 NNS denotes receptors
T2877 2211-2215 DT denotes Both
T2876 2209-2210 . denotes .
T2875 2208-2209 NNP denotes ]
T2874 2206-2208 CD denotes 12
T3540 5878-5881 PRP$ denotes our
T3539 5875-5877 IN denotes in
T3538 5865-5874 VBN denotes generated
T3537 5856-5864 RB denotes recently
T3536 5851-5855 VBD denotes were
T3535 5846-5850 WDT denotes that
T3534 5844-5845 -RRB- denotes )
T3533 5834-5844 JJ denotes A20myel-KO
T3532 5833-5834 -LRB- denotes (
T3531 5828-5832 NNS denotes mice
T3530 5819-5827 NN denotes knockout
T3529 5815-5818 NNP denotes A20
T3528 5806-5814 JJ denotes specific
T3527 5801-5805 NN denotes cell
T3526 5793-5800 JJ denotes myeloid
T3525 5787-5792 VBG denotes Using
T3524 5785-5786 . denotes .
T3523 5776-5785 VBN denotes clarified
T3522 5773-5775 VB denotes be
T3521 5770-5772 TO denotes to
T3520 5762-5769 VBZ denotes remains
T3519 5752-5761 NN denotes infection
T3518 5746-5751 JJ denotes viral
T3517 5743-5745 TO denotes to
T3516 5734-5742 NN denotes response
T3515 5730-5733 DT denotes the
T3514 5727-5729 IN denotes in
T3513 5723-5726 NNP denotes A20
T3512 5720-5722 IN denotes of
T3511 5715-5719 NN denotes role
T3510 5710-5714 NN denotes vivo
T3509 5707-5709 IN denotes in
T3508 5699-5706 JJ denotes precise
T3507 5695-5698 DT denotes the
T3506 5693-5694 , denotes ,
T3505 5686-5693 RB denotes However
T3504 5684-5685 . denotes .
T3503 5683-5684 NNP denotes ]
T3502 5681-5683 CD denotes 52
T3501 5680-5681 NNP denotes [
T3500 5678-5679 NNP denotes ]
T3499 5676-5678 CD denotes 49
T3498 5675-5676 NNP denotes [
T3497 5669-5674 NNP denotes IRF-3
T3496 5665-5668 CC denotes and
T3495 5659-5664 NNP denotes NF-κB
T3494 5656-5658 TO denotes to
T3493 5646-5655 VBG denotes signaling
T3492 5633-5645 JJ denotes TLR3-induced
T3491 5629-5632 CC denotes and
T2873 2205-2206 NNP denotes [
T2872 2203-2204 NNP denotes ]
T2871 2201-2203 CD denotes 10
T2870 2200-2201 NNP denotes [
T2869 2190-2199 NN denotes infection
T2868 2186-2189 NNP denotes IAV
T2867 2183-2185 IN denotes of
T2866 2175-2182 NNS denotes sensors
T2865 2172-2174 IN denotes as
T2864 2161-2171 VBN denotes implicated
T2863 2156-2160 VBN denotes been
T2862 2151-2155 VBP denotes have
T2861 2145-2150 NNP denotes RIG-I
T2860 2141-2144 CC denotes and
T2859 2136-2140 CD denotes TLR3
T2858 2134-2135 . denotes .
T2857 2123-2134 NN denotes replication
T2856 2117-2122 JJ denotes viral
T2855 2114-2116 IN denotes of
T2854 2101-2113 JJ denotes intermediate
T2853 2098-2100 DT denotes an
T2852 2092-2097 VBG denotes being
T2851 2085-2091 JJ denotes latter
T2850 2081-2084 DT denotes the
T2849 2079-2080 , denotes ,
T2848 2076-2079 NNP denotes RNA
T2720 1304-1313 JJ denotes dendritic
T2719 1291-1303 JJ denotes plasmacytoid
T2718 1281-1290 VBG denotes producing
T2717 1277-1280 VBP denotes IFN
T2716 1275-1276 PRP denotes I
T2715 1270-1274 NN denotes type
T2714 1258-1269 VBN denotes specialized
T2713 1255-1257 TO denotes to
T2712 1244-1254 VBN denotes restricted
T2711 1240-1243 VBP denotes are
T2710 1230-1239 NNS denotes responses
T2709 1220-1229 JJ denotes antiviral
T2708 1211-1219 VBD denotes mediated
T2707 1207-1210 NNP denotes TLR
T2706 1205-1206 . denotes .
T2705 1204-1205 NNP denotes ]
T2704 1203-1204 CD denotes 8
T2703 1202-1203 NNP denotes [
T2702 1196-1201 NNP denotes IFI16
T2701 1192-1195 CC denotes and
T2700 1190-1191 NNP denotes ]
T2699 1189-1190 CD denotes 7
T2698 1188-1189 NNP denotes [
T2697 1186-1187 , denotes ,
T2696 1185-1186 NNP denotes ]
T2695 1184-1185 CD denotes 6
T2694 1183-1184 NNP denotes [
T2693 1181-1182 , denotes ,
T2692 1180-1181 NNP denotes ]
T2691 1179-1180 CD denotes 5
T2690 1178-1179 NNP denotes [
T2689 1173-1177 NNP denotes AIM2
T2688 1164-1172 NNS denotes proteins
T2687 1153-1163 VBG denotes containing
T2686 1146-1152 NN denotes domain
T2685 1140-1145 NNP denotes PYHIN
T2684 1136-1139 DT denotes the
T2683 1132-1135 CC denotes and
T2682 1130-1131 NNP denotes ]
T2681 1129-1130 CD denotes 4
T2680 1128-1129 NNP denotes [
T2679 1124-1127 NNP denotes DAI
T2678 1122-1123 , denotes ,
T2677 1118-1122 CD denotes TLR9
T2676 1110-1117 VBP denotes include
T2675 1102-1109 NNS denotes viruses
T2674 1098-1101 NNP denotes DNA
T2673 1095-1097 TO denotes to
T2672 1085-1094 NNS denotes responses
T2671 1078-1084 JJ denotes immune
T2670 1068-1077 JJ denotes antiviral
T2669 1060-1067 VBP denotes mediate
T2668 1055-1059 WDT denotes that
T2667 1047-1054 NNS denotes sensors
T2666 1043-1046 NNP denotes DNA
T2665 1029-1042 NNP denotes Intracellular
T2664 1027-1028 . denotes .
T2663 1026-1027 -RRB- denotes )
T2662 1022-1026 NNP denotes MDA5
T2661 1020-1021 , denotes ,
T2660 1015-1020 NNP denotes RIG-I
T2659 1013-1014 , denotes ,
T2658 1009-1013 CD denotes TLR3
T2657 1008-1009 -LRB- denotes (
T2656 1004-1007 NNP denotes RNA
T2655 995-1003 VBD denotes stranded
T2654 988-994 JJ denotes double
T2653 985-987 CC denotes or
T2652 983-984 -RRB- denotes )
T2651 979-983 NNP denotes Nod2
T2650 977-978 , denotes ,
T2649 973-977 CD denotes TLR8
T2648 971-972 , denotes ,
T2647 967-971 CD denotes TLR7
T2646 966-967 -LRB- denotes (
T2645 957-965 VBN denotes stranded
T2644 950-956 JJ denotes single
T2643 944-949 JJ denotes viral
T2642 941-943 IN denotes of
T2641 932-940 NN denotes presence
T2640 928-931 DT denotes the
T2639 921-927 VBP denotes detect
T2638 919-920 -RRB- denotes )
T2637 915-919 NNS denotes NLRs
T2636 914-915 -LRB- denotes (
T2635 904-913 NNS denotes receptors
T2634 895-903 JJ denotes Nod-like
T2633 892-894 CC denotes or
T2632 890-891 -RRB- denotes )
T2631 886-890 NNS denotes RLRs
T2630 885-886 -LRB- denotes (
T2629 875-884 NNS denotes receptors
T2628 864-874 JJ denotes RIG-I-like
T2627 855-863 NN denotes helicase
T2626 851-854 NNP denotes RNA
T2625 839-850 JJ denotes cytoplasmic
T2624 835-838 CC denotes and
T2623 833-834 -RRB- denotes )
T2622 829-833 NNS denotes TLRs
T2621 828-829 -LRB- denotes (
T2620 818-827 NNS denotes receptors
T2619 808-817 JJ denotes Toll-like
T2618 798-807 NNP denotes Endosomal
T2617 796-797 . denotes .
T2616 795-796 NNP denotes ]
T2615 794-795 CD denotes 3
T2614 793-794 VBP denotes [
T2613 788-792 NNS denotes PRRs
T2612 774-787 JJ denotes intracellular
T2611 765-773 JJ denotes specific
T2610 762-764 IN denotes by
T2609 755-761 VBN denotes sensed
T2608 752-754 VB denotes be
T2607 748-751 MD denotes can
T2606 746-747 , denotes ,
T2605 738-746 NNS denotes products
T2604 724-737 NN denotes transcription
T2603 718-723 JJ denotes viral
T2602 714-717 CC denotes and
T2601 700-713 NNS denotes intermediates
T2600 688-699 NN denotes replication
T2599 682-687 JJ denotes viral
T2598 680-681 , denotes ,
T2597 677-680 NNP denotes DNA
T2596 673-676 CC denotes and
T2595 669-672 NNP denotes RNA
T2594 663-668 JJ denotes viral
T2593 660-662 IN denotes as
T2592 655-659 JJ denotes such
T2591 653-654 , denotes ,
T2590 648-653 NNS denotes acids
T2589 640-647 JJ denotes nucleic
T2588 634-639 JJ denotes viral
T2587 631-633 IN denotes of
T2586 622-630 NN denotes presence
T2585 618-621 DT denotes The
T2584 616-617 . denotes .
T2583 615-616 NNP denotes ]
T2582 614-615 CD denotes 2
T2581 613-614 NNP denotes [
T2580 611-612 , denotes ,
T2579 610-611 NNP denotes ]
T2578 609-610 CD denotes 1
T2577 608-609 NNP denotes [
T2576 603-607 NNP denotes IRF7
T2575 599-602 CC denotes and
T2574 594-598 NNP denotes IRF3
T2573 592-593 , denotes ,
T2572 588-592 NNP denotes AP-1
T2571 586-587 , denotes ,
T2570 581-586 NNP denotes NF-κB
T2569 578-580 IN denotes as
T2568 573-577 JJ denotes such
T2567 565-572 NNS denotes factors
T2566 551-564 NN denotes transcription
T2565 543-550 JJ denotes various
T2564 535-542 VBP denotes control
T2563 530-534 WDT denotes that
T2562 521-529 NNS denotes pathways
T2561 511-520 VBG denotes signaling
T2560 500-510 JJ denotes downstream
T2559 497-499 IN denotes of
T2558 486-496 NN denotes activation
T2557 478-485 IN denotes through
T2556 476-477 -RRB- denotes )
T2555 471-476 NNP denotes IFN-β
T2554 467-470 CC denotes and
T2553 465-466 -RRB- denotes )
T2552 460-465 JJ denotes IFN-α
T2551 459-460 -LRB- denotes (
T2550 446-458 JJ denotes interferon-α
T2549 445-446 -LRB- denotes (
T2548 433-444 VBZ denotes interferons
T2547 431-432 PRP denotes I
T2546 426-430 NN denotes type
T2545 422-425 CC denotes and
T2544 420-421 -RRB- denotes )
T2543 416-420 NNP denotes IL-1
T2542 412-415 CC denotes and
T2541 407-411 NNP denotes IL-6
T2540 405-406 , denotes ,
T2539 402-405 NNP denotes TNF
T2538 397-401 FW denotes e.g.
T2537 396-397 -LRB- denotes (
T2536 386-395 NNS denotes cytokines
T2535 370-385 JJ denotes proinflammatory
T2534 365-369 NN denotes host
T2533 362-364 IN denotes of
T2532 351-361 NN denotes production
T2531 347-350 DT denotes the
T3274 4382-4386 NN denotes zinc
T3273 4373-4381 JJ denotes atypical
T3272 4365-4372 VBZ denotes harbors
T3271 4360-4364 RB denotes also
T3270 4356-4359 NNP denotes A20
T3269 4354-4355 , denotes ,
T3268 4341-4354 RB denotes Interestingly
T3267 4339-4340 . denotes .
T3253 4248-4260 NN denotes transduction
T3252 4241-4247 NN denotes signal
T3251 4231-4240 JJ denotes antiviral
T3250 4223-4230 NNS denotes dampens
T3249 4215-4222 JJ denotes further
T3248 4213-4214 NNP denotes ]
T3247 4211-4213 CD denotes 36
T3246 4210-4211 NNP denotes [
T3245 4204-4209 NNP denotes RBCK1
T3244 4200-4203 CC denotes and
T3243 4198-4199 NNP denotes ]
T3242 4196-4198 CD denotes 35
T3241 4195-4196 NNP denotes [
T3240 4188-4194 CD denotes TRIM21
T3239 4186-4187 , denotes ,
T3238 4185-4186 NNP denotes ]
T3237 4183-4185 CD denotes 34
T3236 4182-4183 NNP denotes [
T3235 4177-4181 NNP denotes RAUL
T3234 4174-4176 IN denotes as
T3233 4169-4173 JJ denotes such
T3232 4165-4168 NNS denotes E3s
T3231 4162-4164 IN denotes by
T3230 4154-4161 NNS denotes factors
T3229 4140-4153 NN denotes transcription
T3228 4135-4139 NNP denotes IRF7
T3227 4131-4134 CC denotes and
T3226 4126-4130 NNP denotes IRF3
T3225 4122-4125 DT denotes the
T3224 4119-4121 TO denotes to
T3223 4112-4118 NNS denotes chains
T3222 4098-4111 NN denotes polyubiquitin
T3221 4085-4097 JJ denotes K48-specific
T3220 4082-4084 IN denotes of
T3219 4071-4081 NN denotes attachment
T3218 4067-4070 DT denotes the
T3217 4065-4066 , denotes ,
T3216 4053-4065 RB denotes Additionally
T3215 4051-4052 . denotes .
T3214 4042-4051 VBG denotes signaling
T3213 4031-4041 JJ denotes downstream
T3212 4023-4030 JJ denotes further
T3211 4012-4022 VBG denotes inhibiting
T3210 4007-4011 RB denotes thus
T3209 4005-4006 , denotes ,
T3208 3994-4005 NN denotes degradation
T3207 3985-3993 JJ denotes mediated
T3206 3974-3984 JJ denotes proteasome
T3205 3970-3973 IN denotes for
T3204 3964-3969 NNP denotes TRAF3
T3203 3960-3963 CC denotes and
T3202 3955-3959 NNP denotes MAVS
T3201 3942-3954 RB denotes respectively
T3200 3937-3941 NN denotes mark
T3199 3935-3936 NNP denotes ]
T3198 3933-3935 CD denotes 33
T3197 3932-3933 NNP denotes [
T3196 3924-3931 NNP denotes TRIAD3A
T3195 3920-3923 CC denotes and
T3194 3918-3919 NNP denotes ]
T3193 3916-3918 CD denotes 32
T3192 3915-3916 NNP denotes [
T3191 3910-3914 NNP denotes AIP4
T3190 3907-3909 IN denotes as
T3189 3902-3906 JJ denotes such
T3188 3900-3901 , denotes ,
T3187 3893-3900 NNS denotes ligases
T3186 3883-3892 NN denotes ubiquitin
T3185 3870-3882 JJ denotes K48-specific
T3184 3862-3869 JJ denotes various
T3183 3860-3861 , denotes ,
T3182 3849-3860 RB denotes Furthermore
T3181 3847-3848 . denotes .
T3180 3838-3847 NNS denotes molecules
T3179 3828-3837 VBG denotes signaling
T3178 3820-3827 JJ denotes several
T3177 3815-3819 IN denotes from
T3176 3808-3814 NNS denotes chains
T3175 3794-3807 NN denotes polyubiquitin
T3174 3783-3793 JJ denotes K63-linked
T3173 3774-3782 VBG denotes removing
T3172 3761-3773 RB denotes specifically
T3171 3758-3760 IN denotes by
T3170 3748-3757 VBG denotes signaling
T3169 3744-3747 NNP denotes RLR
T3168 3735-3743 VB denotes regulate
T3167 3724-3734 RB denotes negatively
T3166 3721-3723 TO denotes to
T3165 3715-3720 VBN denotes shown
T3164 3710-3714 VBN denotes been
T3163 3705-3709 VBP denotes have
T3162 3703-3704 NNP denotes ]
T3161 3701-3703 CD denotes 31
T3160 3700-3701 NNP denotes [
T3159 3692-3699 NNP denotes OTUB1/2
T3158 3688-3691 CC denotes and
T3157 3686-3687 NNP denotes ]
T3156 3684-3686 CD denotes 30
T3155 3683-3684 NNP denotes [
T3154 3681-3682 , denotes ,
T3153 3680-3681 NNP denotes ]
T3152 3678-3680 CD denotes 29
T3151 3677-3678 NNP denotes [
T3150 3672-3676 NNP denotes CYLD
T3149 3670-3671 , denotes ,
T3148 3669-3670 NNP denotes ]
T3147 3667-3669 CD denotes 28
T3146 3666-3667 NNP denotes [
T3145 3661-3665 NNP denotes DUBA
T3144 3658-3660 IN denotes as
T3143 3653-3657 JJ denotes such
T3142 3651-3652 , denotes ,
T3141 3650-3651 -RRB- denotes )
T3140 3646-3650 NNS denotes DUBs
T3139 3645-3646 -LRB- denotes (
T3138 3637-3644 NNS denotes enzymes
T3137 3620-3636 VBG denotes deubiquitinating
T3136 3618-3619 , denotes ,
T3135 3614-3618 NN denotes hand
T3134 3608-3613 JJ denotes other
T3133 3604-3607 DT denotes the
T3132 3601-3603 IN denotes On
T3131 3599-3600 . denotes .
T3130 3588-3599 NN denotes stimulation
T3129 3582-3587 NNP denotes RIG-I
T3128 3577-3581 IN denotes upon
T3127 3566-3576 NN denotes activation
T3126 3561-3565 JJ denotes IRF3
T3125 3557-3560 CC denotes and
T3124 3551-3556 JJ denotes NF-κB
T3123 3538-3550 RB denotes respectively
T3122 3530-3537 VB denotes mediate
T3121 3528-3529 NNP denotes ]
T3120 3526-3528 CD denotes 27
T3119 3525-3526 NNP denotes [
T3118 3519-3524 NNP denotes TRAF3
T3117 3515-3518 CC denotes and
T3116 3513-3514 NNP denotes ]
T3115 3511-3513 CD denotes 26
T3114 3510-3511 NNP denotes [
T3113 3508-3509 , denotes ,
T3112 3507-3508 NNP denotes ]
T3111 3505-3507 CD denotes 25
T3110 3504-3505 NNP denotes [
T3109 3498-3503 CD denotes TRAF6
T3108 3495-3497 IN denotes as
T3107 3490-3494 JJ denotes such
T3106 3482-3489 NNS denotes ligases
T3105 3472-3481 NN denotes ubiquitin
T3104 3458-3471 VBD denotes characterized
T3103 3453-3457 RB denotes well
T3102 3451-3452 , denotes ,
T3101 3443-3451 NN denotes addition
T3100 3440-3442 IN denotes In
T3099 3438-3439 . denotes .
T3098 3428-3438 NN denotes activation
T3097 3422-3427 NNP denotes RIG-I
T3096 3414-3421 VB denotes promote
T3095 3405-3413 RB denotes directly
T3094 3402-3404 TO denotes to
T3093 3396-3401 VBN denotes shown
T3092 3391-3395 VBN denotes been
T3091 3386-3390 VBP denotes have
T3090 3384-3385 , denotes ,
T3089 3383-3384 NNP denotes ]
T3088 3381-3383 CD denotes 24
T3087 3380-3381 NNP denotes [
T3086 3378-3379 , denotes ,
T3085 3377-3378 NNP denotes ]
T3084 3375-3377 CD denotes 23
T3083 3374-3375 NNP denotes [
T3082 3367-3373 NNP denotes Riplet
T3081 3363-3366 CC denotes and
T3080 3361-3362 NNP denotes ]
T3079 3359-3361 CD denotes 22
T3078 3358-3359 NNP denotes [
T3077 3351-3357 CD denotes TRIM25
T3076 3348-3350 IN denotes as
T3075 3343-3347 JJ denotes such
T3074 3341-3342 , denotes ,
T3073 3340-3341 -RRB- denotes )
T3072 3337-3340 NNS denotes E3s
T3071 3336-3337 -LRB- denotes (
T3070 3328-3335 NNS denotes ligases
T3069 3318-3327 NN denotes ubiquitin
T3068 3305-3317 JJ denotes K63-specific
T3067 3303-3304 . denotes .
T3066 3302-3303 NNP denotes ]
T3065 3300-3302 CD denotes 21
T3064 3299-3300 NNP denotes [
T2530 339-346 VBZ denotes induces
T2529 334-338 NNS denotes PRRs
T2528 331-333 IN denotes of
T2527 320-330 VBG denotes Triggering
T2526 318-319 . denotes .
T2525 310-318 NN denotes pathogen
T2524 301-309 VBG denotes invading
T2523 297-300 DT denotes the
T2522 294-296 IN denotes of
T2521 283-293 NNS denotes structures
T2520 273-282 JJ denotes molecular
T2519 263-272 JJ denotes conserved
T2518 256-262 VBP denotes detect
T2517 250-255 WDT denotes which
T2516 248-249 , denotes ,
T2515 247-248 -RRB- denotes )
T2514 244-247 NNP denotes PRR
T2513 243-244 -LRB- denotes (
T2512 233-242 NNS denotes receptors
T2511 221-232 NN denotes recognition
T2510 213-220 NN denotes pattern
T2509 201-212 VBN denotes specialized
T2508 198-200 IN denotes of
T2507 191-197 NN denotes action
T2506 187-190 DT denotes the
T2505 178-186 VBZ denotes involves
T3266 4335-4339 NNS denotes DUBs
T3265 4332-4334 IN denotes of
T3264 4325-4331 NN denotes family
T3263 4314-4324 NNP denotes OTU-domain
T3262 4310-4313 DT denotes the
T3261 4307-4309 TO denotes to
T3260 4297-4306 VBG denotes belonging
T3259 4290-4296 NN denotes enzyme
T3258 4272-4289 JJ denotes ubiquitin-editing
T3257 4269-4271 DT denotes an
T3256 4266-4268 VBZ denotes is
T3255 4262-4265 CD denotes A20
T3254 4260-4261 . denotes .
T2847 2067-2075 VBD denotes stranded
T2846 2060-2066 JJ denotes double
T2845 2056-2059 CC denotes and
T2844 2052-2055 NNP denotes RNA
T2843 2044-2051 JJ denotes genomic
T2842 2028-2043 JJ denotes single-stranded
T2841 2025-2027 IN denotes of
T2840 2020-2024 NN denotes cell
T2839 2015-2019 NN denotes host
T2838 2011-2014 DT denotes the
T2837 2008-2010 IN denotes in
T2836 1999-2007 NN denotes exposure
T2835 1995-1998 DT denotes the
T2834 1992-1994 TO denotes to
T2833 1986-1991 VBZ denotes leads
T2832 1976-1985 NN denotes infection
T2831 1972-1975 NNP denotes IAV
T2830 1970-1971 . denotes .
T2829 1962-1970 JJ denotes critical
T2828 1959-1961 VBZ denotes is
T2827 1949-1958 NNS denotes responses
T2826 1942-1948 JJ denotes immune
T2825 1930-1941 JJ denotes IAV-induced
T2824 1921-1929 VBP denotes regulate
T2823 1916-1920 WDT denotes that
T2822 1905-1915 NNS denotes mechanisms
T2821 1901-1904 DT denotes the
T2820 1898-1900 IN denotes of
T2819 1884-1897 NN denotes understanding
T2818 1882-1883 , denotes ,
T2817 1875-1882 NN denotes context
T2816 1870-1874 DT denotes this
T2815 1867-1869 IN denotes In
T2814 1865-1866 . denotes .
T2813 1855-1865 NNS denotes strategies
T2812 1845-1854 JJ denotes antiviral
T2811 1839-1844 NN denotes novel
T2810 1828-1838 VBG denotes developing
T2809 1825-1827 IN denotes of
T2808 1814-1824 NN denotes importance
T2807 1810-1813 DT denotes the
T2806 1798-1809 VBZ denotes underscores
T2805 1788-1797 JJ denotes potential
T2804 1779-1787 JJ denotes pandemic
T2803 1774-1778 IN denotes with
T2802 1766-1773 NNS denotes viruses
T2801 1756-1765 NN denotes influenza
T2800 1753-1755 IN denotes of
T2799 1745-1752 NNS denotes strains
T2798 1730-1744 JJ denotes drug-resistant
T2797 1727-1729 IN denotes of
T2796 1717-1726 NN denotes Emergence
T2795 1715-1716 . denotes .
T2794 1707-1715 NN denotes response
T2793 1694-1706 JJ denotes inflammatory
T2792 1689-1693 NN denotes host
T2791 1679-1688 JJ denotes excessive
T2790 1676-1678 DT denotes an
T2789 1673-1675 TO denotes to
T2788 1669-1672 JJ denotes due
T2787 1666-1668 VB denotes be
T2786 1663-1665 TO denotes to
T2785 1654-1662 VBN denotes believed
T2784 1644-1653 RB denotes generally
T2783 1641-1643 VBZ denotes is
T2782 1635-1640 WDT denotes which
T2781 1633-1634 , denotes ,
T2780 1624-1633 NN denotes mortality
T2779 1611-1623 JJ denotes considerable
T2778 1604-1610 VBZ denotes causes
T2777 1599-1603 WDT denotes that
T2776 1591-1598 NN denotes disease
T2775 1579-1590 JJ denotes respiratory
T2774 1573-1578 JJ denotes acute
T2773 1562-1572 JJ denotes contagious
T2772 1560-1561 DT denotes a
T2771 1557-1559 IN denotes of
T2770 1551-1556 NN denotes agent
T2769 1539-1550 JJ denotes etiological
T2768 1535-1538 DT denotes the
T2767 1532-1534 VBZ denotes is
T2766 1530-1531 -RRB- denotes )
T2765 1527-1530 NNP denotes IAV
T2764 1526-1527 -LRB- denotes (
T2763 1520-1525 NN denotes virus
T2762 1518-1519 NNP denotes A
T2761 1508-1517 NNP denotes Influenza
T2760 1506-1507 . denotes .
T2759 1505-1506 NNP denotes ]
T2758 1504-1505 CD denotes 9
T2757 1503-1504 VBP denotes [
T2756 1494-1502 NNS denotes proteins
T2755 1484-1493 JJ denotes antiviral
T2754 1481-1483 IN denotes of
T2753 1470-1480 NN denotes production
T2752 1466-1469 DT denotes the
T2751 1462-1465 IN denotes for
T2750 1454-1461 NNS denotes sensors
T2749 1450-1453 NNP denotes DNA
T2748 1446-1449 CC denotes and
T2747 1442-1445 NNP denotes RNA
T2746 1432-1441 JJ denotes cytosolic
T2745 1428-1431 DT denotes the
T2744 1425-1427 IN denotes on
T2743 1418-1424 VBP denotes depend
T2742 1416-1417 , denotes ,
T2741 1405-1416 NNS denotes fibroblasts
T2740 1401-1404 CC denotes and
T2739 1389-1400 NNS denotes macrophages
T2738 1387-1388 , denotes ,
T2737 1386-1387 -RRB- denotes )
T2736 1383-1386 NNP denotes cDC
T2735 1382-1383 -LRB- denotes (
T2734 1379-1381 NNP denotes DC
T2733 1366-1378 JJ denotes conventional
T2732 1356-1365 VBG denotes including
T2731 1354-1355 , denotes ,
T2730 1349-1354 NNS denotes types
T2729 1344-1348 NN denotes cell
T2728 1338-1343 JJ denotes other
T2727 1333-1337 RBS denotes most
T2726 1327-1332 IN denotes while
T2725 1325-1326 , denotes ,
T2724 1324-1325 -RRB- denotes )
T2723 1321-1324 NNP denotes pDC
T2722 1320-1321 -LRB- denotes (
T2721 1314-1319 NNS denotes cells
T2504 169-177 NN denotes response
T2503 162-168 JJ denotes immune
T2502 152-161 JJ denotes antiviral
T2501 145-151 NN denotes innate
T2500 134-144 JJ denotes protective
T2499 132-133 DT denotes a
T2498 129-131 IN denotes of
T2497 118-128 NN denotes initiation
T2496 114-117 DT denotes The
T2495 112-113 . denotes .
T2494 101-112 NN denotes replication
T2493 95-100 PRP$ denotes their
T2492 91-94 IN denotes for
T2491 86-90 NN denotes cell
T2490 81-85 NN denotes host
T2489 77-80 DT denotes the
T2488 74-76 IN denotes on
T2487 67-73 VBP denotes depend
T2486 61-66 WDT denotes which
T2485 51-60 NNS denotes pathogens
T2484 43-50 JJ denotes diverse
T2483 36-42 RB denotes highly
T2482 33-35 IN denotes of
T2481 27-32 NN denotes class
T2480 25-26 DT denotes a
T2479 21-24 VBP denotes are
T2478 13-20 NNS denotes Viruses
T3647 6573-6574 . denotes .
T3646 6564-6573 NN denotes potential
T3645 6552-6563 JJ denotes therapeutic
T3644 6547-6551 VB denotes have
T3643 6541-6546 MD denotes might
T3642 6535-6540 NNS denotes cells
T3641 6527-6534 JJ denotes myeloid
T3640 6524-6526 IN denotes in
T3639 6515-6523 NN denotes activity
T3638 6511-6514 JJ denotes A20
T3637 6501-6510 VBG denotes targeting
T3636 6498-6500 IN denotes by
T3635 6494-6497 NNP denotes IAV
T3634 6491-6493 TO denotes to
T3633 6482-6490 NN denotes response
T3632 6475-6481 JJ denotes immune
T3631 6468-6474 NN denotes innate
T3630 6464-6467 DT denotes the
T3629 6455-6463 VBG denotes boosting
T3628 6450-6454 IN denotes that
T3627 6442-6449 VBP denotes suggest
T3626 6434-6441 NNS denotes results
T3625 6428-6433 DT denotes These
T3624 6426-6427 . denotes .
T3623 6417-6426 NN denotes clearance
T3622 6411-6416 JJ denotes viral
T3621 6402-6410 JJ denotes enhanced
T3620 6398-6401 CC denotes and
T3619 6396-6397 , denotes ,
T3618 6385-6396 NNS denotes macrophages
T3617 6376-6384 JJ denotes alveolar
T3616 6372-6375 CC denotes and
T3615 6361-6371 NNS denotes neutophils
T3614 6358-6360 IN denotes as
T3613 6353-6357 JJ denotes such
R1724 T2478 T2479 nsubj Viruses,are
R1736 T2479 T2479 ROOT are,are
R1739 T2480 T2481 det a,class
R1741 T2481 T2479 attr class,are
R1743 T2482 T2481 prep of,class
R1744 T2483 T2484 advmod highly,diverse
R1747 T2484 T2485 amod diverse,pathogens
R1749 T2485 T2482 pobj pathogens,of
R1750 T2486 T2487 nsubj which,depend
R1753 T2487 T2485 relcl depend,pathogens
R1760 T2488 T2487 prep on,depend
R1762 T2489 T2491 det the,cell
R1766 T2490 T2491 compound host,cell
R1772 T2491 T2488 pobj cell,on
R1775 T2492 T2491 prep for,cell
R1776 T2493 T2494 poss their,replication
R1777 T2494 T2492 pobj replication,for
R1778 T2495 T2479 punct .,are
R1779 T2496 T2497 det The,initiation
R1780 T2497 T2505 nsubj initiation,involves
R1781 T2546 T2539 conj type,TNF
R1782 T2498 T2497 prep of,initiation
R1783 T2547 T2548 nsubj I,interferons
R1784 T2548 T2536 parataxis interferons,cytokines
R1785 T2499 T2504 det a,response
R1786 T2549 T2552 punct (,IFN-α
R1787 T2550 T2552 amod interferon-α,IFN-α
R1788 T2500 T2501 amod protective,innate
R1789 T2551 T2552 punct (,IFN-α
R1790 T2501 T2504 amod innate,response
R1791 T2552 T2548 appos IFN-α,interferons
R1792 T2553 T2552 punct ),IFN-α
R1793 T2502 T2504 amod antiviral,response
R1794 T2554 T2548 cc and,interferons
R1795 T2555 T2548 conj IFN-β,interferons
R1796 T2556 T2548 punct ),interferons
R1797 T2503 T2504 amod immune,response
R1798 T2557 T2530 prep through,induces
R1799 T2558 T2557 pobj activation,through
R1800 T2504 T2498 pobj response,of
R1801 T2559 T2558 prep of,activation
R1802 T2560 T2562 amod downstream,pathways
R1803 T2561 T2562 compound signaling,pathways
R1804 T2505 T2505 ROOT involves,involves
R1805 T2562 T2559 pobj pathways,of
R1806 T2563 T2564 nsubj that,control
R1807 T2506 T2507 det the,action
R1808 T2564 T2562 relcl control,pathways
R1809 T2565 T2567 amod various,factors
R1810 T2507 T2505 dobj action,involves
R1811 T2566 T2567 compound transcription,factors
R1812 T2567 T2564 dobj factors,control
R1813 T2568 T2569 amod such,as
R1814 T2508 T2507 prep of,action
R1815 T2569 T2567 prep as,factors
R1816 T2570 T2569 pobj NF-κB,as
R1817 T2571 T2570 punct ",",NF-κB
R1818 T2572 T2570 conj AP-1,NF-κB
R1819 T2509 T2512 amod specialized,receptors
R1820 T2573 T2572 punct ",",AP-1
R1821 T2574 T2572 conj IRF3,AP-1
R1822 T2510 T2511 compound pattern,recognition
R1823 T2575 T2574 cc and,IRF3
R1824 T2576 T2577 compound IRF7,[
R1825 T2577 T2574 conj [,IRF3
R1826 T2578 T2579 nummod 1,]
R1827 T2511 T2512 compound recognition,receptors
R1828 T2579 T2577 conj ],[
R1829 T2580 T2579 punct ",",]
R1830 T2581 T2583 nmod [,]
R1831 T2582 T2583 nummod 2,]
R1832 T2583 T2579 conj ],]
R1833 T2584 T2530 punct .,induces
R1834 T2512 T2508 pobj receptors,of
R1835 T2585 T2586 det The,presence
R1836 T2586 T2609 nsubjpass presence,sensed
R1837 T2587 T2586 prep of,presence
R1838 T2513 T2512 punct (,receptors
R1839 T2588 T2590 amod viral,acids
R1840 T2589 T2590 amod nucleic,acids
R1841 T2590 T2587 pobj acids,of
R1842 T2514 T2512 appos PRR,receptors
R1843 T2591 T2590 punct ",",acids
R1844 T2592 T2593 amod such,as
R1845 T2593 T2590 prep as,acids
R1846 T2515 T2514 punct ),PRR
R1847 T2594 T2595 amod viral,RNA
R1848 T2595 T2593 pobj RNA,as
R1849 T2596 T2595 cc and,RNA
R1850 T2516 T2512 punct ",",receptors
R1851 T2597 T2595 conj DNA,RNA
R1852 T2598 T2597 punct ",",DNA
R1853 T2599 T2601 amod viral,intermediates
R1854 T2517 T2518 nsubj which,detect
R1855 T2600 T2601 compound replication,intermediates
R1856 T2601 T2597 conj intermediates,DNA
R1857 T2602 T2601 cc and,intermediates
R1858 T2518 T2512 relcl detect,receptors
R1859 T2603 T2604 amod viral,transcription
R1860 T2604 T2605 compound transcription,products
R1861 T2519 T2521 amod conserved,structures
R1862 T2605 T2601 conj products,intermediates
R1863 T2606 T2609 punct ",",sensed
R1864 T2607 T2609 aux can,sensed
R1865 T2520 T2521 amod molecular,structures
R1866 T2608 T2609 auxpass be,sensed
R1867 T2521 T2518 dobj structures,detect
R1868 T2522 T2521 prep of,structures
R1869 T2609 T2609 ROOT sensed,sensed
R1870 T2610 T2609 agent by,sensed
R1871 T2523 T2525 det the,pathogen
R1872 T2611 T2613 amod specific,PRRs
R1873 T2612 T2613 amod intracellular,PRRs
R1874 T2613 T2610 pobj PRRs,by
R1875 T2524 T2525 amod invading,pathogen
R1876 T2614 T2616 nmod [,]
R1877 T2615 T2616 nummod 3,]
R1878 T2616 T2609 npadvmod ],sensed
R1879 T2617 T2609 punct .,sensed
R1880 T2618 T2620 nmod Endosomal,receptors
R1881 T2619 T2620 amod Toll-like,receptors
R1882 T2525 T2522 pobj pathogen,of
R1883 T2620 T2639 nsubj receptors,detect
R1884 T2621 T2622 punct (,TLRs
R1885 T2622 T2620 appos TLRs,receptors
R1886 T2526 T2505 punct .,involves
R1887 T2623 T2622 punct ),TLRs
R1888 T2624 T2622 cc and,TLRs
R1889 T2625 T2629 nmod cytoplasmic,receptors
R1890 T2527 T2530 csubj Triggering,induces
R1891 T2626 T2627 compound RNA,helicase
R1892 T2627 T2629 nmod helicase,receptors
R1893 T2628 T2629 compound RIG-I-like,receptors
R1894 T2528 T2527 prep of,Triggering
R1895 T2629 T2622 conj receptors,TLRs
R1896 T2529 T2528 pobj PRRs,of
R1897 T2530 T2530 ROOT induces,induces
R1898 T2630 T2629 punct (,receptors
R1899 T2631 T2629 conj RLRs,receptors
R1900 T2632 T2629 punct ),receptors
R1901 T2531 T2532 det the,production
R1902 T2633 T2629 cc or,receptors
R1903 T2634 T2635 amod Nod-like,receptors
R1904 T2635 T2629 conj receptors,receptors
R1905 T2532 T2530 dobj production,induces
R1906 T2636 T2637 punct (,NLRs
R1907 T2637 T2635 appos NLRs,receptors
R1908 T2533 T2532 prep of,production
R1909 T2638 T2635 punct ),receptors
R1910 T2639 T2639 ROOT detect,detect
R1911 T2640 T2641 det the,presence
R1912 T2534 T2536 nmod host,cytokines
R1913 T2641 T2639 dobj presence,detect
R1914 T2642 T2641 prep of,presence
R1915 T2535 T2536 compound proinflammatory,cytokines
R1916 T2536 T2533 pobj cytokines,of
R1917 T2537 T2548 punct (,interferons
R1918 T2538 T2539 compound e.g.,TNF
R1919 T2643 T2645 amod viral,stranded
R1920 T2644 T2645 amod single,stranded
R1921 T2645 T2639 advcl stranded,detect
R1922 T2539 T2548 nmod TNF,interferons
R1923 T2646 T2645 punct (,stranded
R1924 T2647 T2645 appos TLR7,stranded
R1925 T2540 T2539 punct ",",TNF
R1926 T2648 T2647 punct ",",TLR7
R1927 T2649 T2647 appos TLR8,TLR7
R1928 T2650 T2645 punct ",",stranded
R1929 T2651 T2645 npadvmod Nod2,stranded
R1930 T2652 T2645 punct ),stranded
R1931 T2653 T2645 cc or,stranded
R1932 T2541 T2539 conj IL-6,TNF
R1933 T2654 T2655 advmod double,stranded
R1934 T2655 T2645 conj stranded,stranded
R1935 T2656 T2655 dobj RNA,stranded
R1936 T2542 T2541 cc and,IL-6
R1937 T2657 T2656 punct (,RNA
R1938 T2658 T2656 appos TLR3,RNA
R1939 T2659 T2656 punct ",",RNA
R1940 T2543 T2541 conj IL-1,IL-6
R1941 T2660 T2656 conj RIG-I,RNA
R1942 T2661 T2660 punct ",",RIG-I
R1943 T2544 T2543 punct ),IL-1
R1944 T2662 T2660 conj MDA5,RIG-I
R1945 T2663 T2655 punct ),stranded
R1946 T2664 T2645 punct .,stranded
R1947 T2545 T2539 cc and,TNF
R1948 T2665 T2666 compound Intracellular,DNA
R1949 T2666 T2667 compound DNA,sensors
R1950 T2740 T2739 cc and,macrophages
R1951 T2667 T2676 nsubj sensors,include
R1952 T2668 T2669 nsubj that,mediate
R1953 T2669 T2667 relcl mediate,sensors
R1954 T2670 T2672 amod antiviral,responses
R1955 T2671 T2672 amod immune,responses
R1956 T2741 T2739 conj fibroblasts,macrophages
R1957 T2672 T2669 dobj responses,mediate
R1958 T2673 T2672 prep to,responses
R1959 T2742 T2743 punct ",",depend
R1960 T2674 T2675 compound DNA,viruses
R1961 T2675 T2673 pobj viruses,to
R1962 T2676 T2676 ROOT include,include
R1963 T2743 T2712 advcl depend,restricted
R1964 T2677 T2676 dobj TLR9,include
R1965 T2678 T2677 punct ",",TLR9
R1966 T2744 T2743 prep on,depend
R1967 T2679 T2680 compound DAI,[
R1968 T2680 T2677 appos [,TLR9
R1969 T2681 T2682 nummod 4,]
R1970 T2745 T2747 det the,RNA
R1971 T2682 T2680 dobj ],[
R1972 T2683 T2682 cc and,]
R1973 T2684 T2686 det the,domain
R1974 T2746 T2747 compound cytosolic,RNA
R1975 T2685 T2686 compound PYHIN,domain
R1976 T2686 T2682 conj domain,]
R1977 T2687 T2686 acl containing,domain
R1978 T2747 T2744 pobj RNA,on
R1979 T2688 T2687 dobj proteins,containing
R1980 T2689 T2690 compound AIM2,[
R1981 T2690 T2692 nmod [,]
R1982 T2691 T2692 nummod 5,]
R1983 T2692 T2688 appos ],proteins
R1984 T2748 T2747 cc and,RNA
R1985 T2693 T2692 punct ",",]
R1986 T2694 T2696 compound [,]
R1987 T2695 T2696 compound 6,]
R1988 T2696 T2692 conj ],]
R1989 T2749 T2747 conj DNA,RNA
R1990 T2697 T2696 punct ",",]
R1991 T2698 T2696 conj [,]
R1992 T2750 T2743 dobj sensors,depend
R1993 T2699 T2700 nummod 7,]
R1994 T2700 T2698 dobj ],[
R1995 T2701 T2700 cc and,]
R1996 T2702 T2703 compound IFI16,[
R1997 T2751 T2743 prep for,depend
R1998 T2703 T2700 conj [,]
R1999 T2704 T2705 nummod 8,]
R2000 T2705 T2700 conj ],]
R2001 T2752 T2753 det the,production
R2002 T2706 T2676 punct .,include
R2003 T2707 T2708 nsubj TLR,mediated
R2004 T2753 T2751 pobj production,for
R2005 T2708 T2708 ROOT mediated,mediated
R2006 T2754 T2753 prep of,production
R2007 T2709 T2710 amod antiviral,responses
R2008 T2710 T2712 nsubjpass responses,restricted
R2009 T2755 T2756 amod antiviral,proteins
R2010 T2711 T2712 auxpass are,restricted
R2011 T2712 T2708 ccomp restricted,mediated
R2012 T2713 T2712 prep to,restricted
R2013 T2714 T2715 amod specialized,type
R2014 T2756 T2754 pobj proteins,of
R2015 T2715 T2713 pobj type,to
R2016 T2716 T2718 nsubj I,producing
R2017 T2757 T2743 conj [,depend
R2018 T2717 T2718 aux IFN,producing
R2019 T2718 T2715 relcl producing,type
R2020 T2758 T2759 nummod 9,]
R2021 T2719 T2721 amod plasmacytoid,cells
R2022 T2720 T2721 amod dendritic,cells
R2023 T2721 T2718 dobj cells,producing
R2024 T2759 T2757 dobj ],[
R2025 T2722 T2721 punct (,cells
R2026 T2723 T2721 appos pDC,cells
R2027 T2760 T2708 punct .,mediated
R2028 T2724 T2721 punct ),cells
R2029 T2725 T2718 punct ",",producing
R2030 T2726 T2743 mark while,depend
R2031 T2727 T2730 amod most,types
R2032 T2728 T2730 amod other,types
R2033 T2729 T2730 compound cell,types
R2034 T2730 T2743 nsubj types,depend
R2035 T2761 T2767 nsubj Influenza,is
R2036 T2731 T2730 punct ",",types
R2037 T2732 T2730 prep including,types
R2038 T2733 T2734 amod conventional,DC
R2039 T2762 T2763 det A,virus
R2040 T2734 T2732 pobj DC,including
R2041 T2735 T2736 punct (,cDC
R2042 T2736 T2730 appos cDC,types
R2043 T2763 T2761 appos virus,Influenza
R2044 T2737 T2736 punct ),cDC
R2045 T2738 T2736 punct ",",cDC
R2046 T2739 T2736 conj macrophages,cDC
R2047 T2764 T2765 punct (,IAV
R2048 T2765 T2763 appos IAV,virus
R2049 T2766 T2763 punct ),virus
R2050 T2767 T2767 ROOT is,is
R2051 T2768 T2770 det the,agent
R2052 T2837 T2836 prep in,exposure
R2053 T2769 T2770 amod etiological,agent
R2054 T2838 T2840 det the,cell
R2055 T2839 T2840 compound host,cell
R2056 T2770 T2767 attr agent,is
R2057 T2840 T2837 pobj cell,in
R2058 T2841 T2840 prep of,cell
R2059 T2842 T2844 amod single-stranded,RNA
R2060 T2771 T2770 prep of,agent
R2061 T2843 T2844 compound genomic,RNA
R2062 T2844 T2841 pobj RNA,of
R2063 T2772 T2776 det a,disease
R2064 T2845 T2836 cc and,exposure
R2065 T2773 T2776 amod contagious,disease
R2066 T2846 T2847 nsubj double,stranded
R2067 T2774 T2776 amod acute,disease
R2068 T2847 T2833 ccomp stranded,leads
R2069 T2848 T2847 dobj RNA,stranded
R2070 T2775 T2776 amod respiratory,disease
R2071 T2849 T2848 punct ",",RNA
R2072 T2850 T2851 det the,latter
R2073 T2851 T2852 nsubj latter,being
R2074 T2776 T2771 pobj disease,of
R2075 T2852 T2847 advcl being,stranded
R2076 T2853 T2854 det an,intermediate
R2077 T2777 T2778 nsubj that,causes
R2078 T2854 T2852 attr intermediate,being
R2079 T2855 T2854 prep of,intermediate
R2080 T2856 T2857 amod viral,replication
R2081 T2857 T2855 pobj replication,of
R2082 T2858 T2833 punct .,leads
R2083 T2778 T2776 relcl causes,disease
R2084 T2859 T2864 nsubjpass TLR3,implicated
R2085 T2860 T2859 cc and,TLR3
R2086 T2861 T2859 conj RIG-I,TLR3
R2087 T2779 T2780 amod considerable,mortality
R2088 T2862 T2864 aux have,implicated
R2089 T2863 T2864 auxpass been,implicated
R2090 T2864 T2864 ROOT implicated,implicated
R2091 T2780 T2778 dobj mortality,causes
R2092 T2865 T2864 prep as,implicated
R2093 T2866 T2865 pobj sensors,as
R2094 T2781 T2780 punct ",",mortality
R2095 T2782 T2785 nsubjpass which,believed
R2096 T2867 T2866 prep of,sensors
R2097 T2783 T2785 auxpass is,believed
R2098 T2784 T2785 advmod generally,believed
R2099 T2868 T2869 compound IAV,infection
R2100 T2869 T2867 pobj infection,of
R2101 T2870 T2872 nmod [,]
R2102 T2785 T2780 relcl believed,mortality
R2103 T2871 T2872 nummod 10,]
R2104 T2872 T2866 appos ],sensors
R2105 T2873 T2875 nmod [,]
R2106 T2786 T2787 aux to,be
R2107 T2874 T2875 nummod 12,]
R2108 T2875 T2872 appos ],]
R2109 T2787 T2785 xcomp be,believed
R2110 T2876 T2864 punct .,implicated
R2111 T2877 T2878 det Both,receptors
R2112 T2878 T2879 nsubj receptors,contribute
R2113 T2788 T2787 acomp due,be
R2114 T2879 T2879 ROOT contribute,contribute
R2115 T2880 T2879 prep to,contribute
R2116 T2881 T2883 det the,response
R2117 T2789 T2788 prep to,due
R2118 T2882 T2883 amod proinflammatory,response
R2119 T2883 T2880 pobj response,to
R2120 T2790 T2794 det an,response
R2121 T2884 T2883 prep to,response
R2122 T2885 T2884 pobj IAV,to
R2123 T2886 T2879 punct ",",contribute
R2124 T2791 T2794 amod excessive,response
R2125 T2887 T2879 cc but,contribute
R2126 T2888 T2889 det the,initiation
R2127 T2792 T2794 nmod host,response
R2128 T2889 T2897 nsubj initiation,depends
R2129 T2890 T2889 prep of,initiation
R2130 T2891 T2895 det the,response
R2131 T2892 T2895 amod innate,response
R2132 T2893 T2895 amod antiviral,response
R2133 T2894 T2895 amod immune,response
R2134 T2793 T2794 amod inflammatory,response
R2135 T2895 T2890 pobj response,of
R2136 T2896 T2897 advmod largely,depends
R2137 T2897 T2879 conj depends,contribute
R2138 T2794 T2789 pobj response,to
R2139 T2898 T2897 prep on,depends
R2140 T2899 T2900 nsubj RIG-I,mediated
R2141 T2900 T2879 conj mediated,contribute
R2142 T2795 T2767 punct .,is
R2143 T2901 T2900 xcomp signaling,mediated
R2144 T2902 T2904 nmod [,]
R2145 T2903 T2904 nummod 13,]
R2146 T2904 T2901 dobj ],signaling
R2147 T2796 T2806 nsubj Emergence,underscores
R2148 T2905 T2900 punct .,mediated
R2149 T2906 T2911 advmod Interestingly,are
R2150 T2907 T2911 punct ",",are
R2151 T2797 T2796 prep of,Emergence
R2152 T2908 T2910 nmod RIG-I,mice
R2153 T2909 T2910 amod deficient,mice
R2154 T2910 T2911 nsubj mice,are
R2155 T2798 T2799 amod drug-resistant,strains
R2156 T2911 T2911 ROOT are,are
R2157 T2912 T2913 advmod highly,susceptible
R2158 T2799 T2797 pobj strains,of
R2159 T2913 T2911 acomp susceptible,are
R2160 T2914 T2913 prep to,susceptible
R2161 T2915 T2916 compound IAV,[
R2162 T2916 T2914 pobj [,to
R2163 T2800 T2799 prep of,strains
R2164 T2917 T2918 nummod 14,]
R2165 T2918 T2916 appos ],[
R2166 T2801 T2802 compound influenza,viruses
R2167 T2919 T2918 punct ",",]
R2168 T2920 T2922 nmod [,]
R2169 T2921 T2922 nummod 15,]
R2170 T2922 T2916 conj ],[
R2171 T2802 T2800 pobj viruses,of
R2172 T2923 T2911 punct ",",are
R2173 T2924 T2928 mark whereas,have
R2174 T2803 T2799 prep with,strains
R2175 T2925 T2927 nummod TLR3,mice
R2176 T2926 T2927 amod deficient,mice
R2177 T2927 T2928 nsubj mice,have
R2178 T2928 T2911 advcl have,are
R2179 T2804 T2805 amod pandemic,potential
R2180 T2929 T2931 det a,advantage
R2181 T2930 T2931 compound survival,advantage
R2182 T2931 T2928 dobj advantage,have
R2183 T2932 T2931 prep to,advantage
R2184 T2933 T2934 amod acute,infection
R2185 T2805 T2803 pobj potential,with
R2186 T2806 T2806 ROOT underscores,underscores
R2187 T2807 T2808 det the,importance
R2188 T2934 T2932 pobj infection,to
R2189 T2935 T2932 pobj [,to
R2190 T2808 T2806 dobj importance,underscores
R2191 T2936 T2937 nummod 16,]
R2192 T2937 T2935 dobj ],[
R2193 T2938 T2911 punct .,are
R2194 T2809 T2808 prep of,importance
R2195 T2939 T2940 det These,results
R2196 T2940 T2941 nsubj results,indicate
R2197 T2941 T2941 ROOT indicate,indicate
R2198 T2810 T2809 pcomp developing,of
R2199 T2942 T2957 mark that,is
R2200 T2943 T2944 det an,imbalance
R2201 T2944 T2957 nsubj imbalance,is
R2202 T2811 T2813 amod novel,strategies
R2203 T2945 T2944 prep between,imbalance
R2204 T2946 T2950 det the,effects
R2205 T2812 T2813 amod antiviral,strategies
R2206 T2947 T2950 amod beneficial,effects
R2207 T2813 T2810 dobj strategies,developing
R2208 T2814 T2806 punct .,underscores
R2209 T2948 T2947 cc and,beneficial
R2210 T2815 T2828 prep In,is
R2211 T2949 T2947 conj harmful,beneficial
R2212 T2950 T2945 pobj effects,between
R2213 T2816 T2817 det this,context
R2214 T2951 T2950 prep of,effects
R2215 T2952 T2951 pobj mediators,of
R2216 T2953 T2950 acl released,effects
R2217 T2817 T2815 pobj context,In
R2218 T2954 T2953 agent by,released
R2219 T2955 T2956 amod immune,cells
R2220 T2956 T2954 pobj cells,by
R2221 T2818 T2828 punct ",",is
R2222 T2957 T2941 ccomp is,indicate
R2223 T2958 T2957 acomp likely,is
R2224 T2819 T2828 nsubj understanding,is
R2225 T2959 T2960 aux to,contribute
R2226 T2960 T2958 xcomp contribute,likely
R2227 T2961 T2960 prep to,contribute
R2228 T2820 T2819 prep of,understanding
R2229 T2962 T2963 det the,pathogenesis
R2230 T2963 T2961 pobj pathogenesis,to
R2231 T2964 T2963 prep of,pathogenesis
R2232 T2965 T2964 pobj influenza,of
R2233 T2966 T2941 punct .,indicate
R2234 T2967 T2968 nsubj RIG-I,contains
R2235 T2821 T2822 det the,mechanisms
R2236 T2968 T2968 ROOT contains,contains
R2237 T2969 T2974 det a,domain
R2238 T2970 T2972 amod C-terminal,box
R2239 T2822 T2820 pobj mechanisms,of
R2240 T2971 T2972 compound DExD/H,box
R2241 T2972 T2974 compound box,domain
R2242 T2973 T2974 compound helicase,domain
R2243 T2974 T2968 dobj domain,contains
R2244 T2823 T2824 nsubj that,regulate
R2245 T2824 T2822 relcl regulate,mechanisms
R2246 T2975 T2974 punct ",",domain
R2247 T2825 T2827 amod IAV-induced,responses
R2248 T2976 T2978 nsubjpass which,required
R2249 T2977 T2978 auxpass is,required
R2250 T2978 T2974 relcl required,domain
R2251 T2826 T2827 amod immune,responses
R2252 T2979 T2978 prep for,required
R2253 T2980 T2981 compound ligand,recognition
R2254 T2981 T2979 pobj recognition,for
R2255 T2827 T2824 dobj responses,regulate
R2256 T2982 T2974 punct ",",domain
R2257 T2983 T2974 cc and,domain
R2258 T2984 T2987 nummod two,domains
R2259 T2828 T2828 ROOT is,is
R2260 T2985 T2986 compound N-terminal,CARD
R2261 T2986 T2987 compound CARD,domains
R2262 T2987 T2974 conj domains,domain
R2263 T2988 T2968 punct .,contains
R2264 T2829 T2828 acomp critical,is
R2265 T2989 T2989 ROOT Upon,Upon
R2266 T2990 T2991 compound ligand,binding
R2267 T2991 T2989 pobj binding,Upon
R2268 T2830 T2828 punct .,is
R2269 T2992 T2995 punct ",",domains
R2270 T2993 T2995 det the,domains
R2271 T2994 T2995 compound CARD,domains
R2272 T2831 T2832 compound IAV,infection
R2273 T2995 T2991 conj domains,binding
R2274 T2996 T2995 prep of,domains
R2275 T2997 T2998 compound RIG-I,associate
R2276 T2832 T2833 nsubj infection,leads
R2277 T2998 T2996 pobj associate,of
R2278 T2999 T2998 prep with,associate
R2279 T3000 T3002 det the,domain
R2280 T2833 T2833 ROOT leads,leads
R2281 T3001 T3002 compound CARD,domain
R2282 T3002 T2999 pobj domain,with
R2283 T3003 T3002 prep of,domain
R2284 T3004 T3005 det the,MAVS
R2285 T3005 T3003 pobj MAVS,of
R2286 T3006 T3008 punct (,termed
R2287 T2834 T2833 prep to,leads
R2288 T3007 T3008 advmod also,termed
R2289 T3008 T3005 parataxis termed,MAVS
R2290 T3009 T3008 oprd IPS-1,termed
R2291 T2835 T2836 det the,exposure
R2292 T3010 T3009 punct ",",IPS-1
R2293 T3011 T3016 nmod VISA,protein
R2294 T3012 T3011 punct ",",VISA
R2295 T2836 T2834 pobj exposure,to
R2296 T3013 T3011 appos Cardif,VISA
R2297 T3014 T3016 punct ),protein
R2298 T3015 T3016 compound adaptor,protein
R2299 T3031 T3033 amod C-terminal,domain
R2300 T3016 T3009 appos protein,IPS-1
R2301 T3017 T3016 punct ",",protein
R2302 T3018 T3020 nsubj which,translocates
R2303 T3019 T3020 advmod subsequently,translocates
R2304 T3020 T3016 relcl translocates,protein
R2305 T3021 T3020 prep to,translocates
R2306 T3032 T3033 compound transmembrane,domain
R2307 T3022 T3020 cc and,translocates
R2308 T3023 T3020 conj inserts,translocates
R2309 T3024 T3023 prep in,inserts
R2310 T3033 T3029 pobj domain,via
R2311 T3025 T3028 det the,membrane
R2312 T3034 T3036 nmod [,]
R2313 T3026 T3028 amod outer,membrane
R2314 T3035 T3036 nummod 17,]
R2315 T3027 T3028 amod mitochondrial,membrane
R2316 T3028 T3024 pobj membrane,in
R2317 T3029 T3023 prep via,inserts
R2318 T3036 T3023 conj ],inserts
R2319 T3030 T3033 poss its,domain
R2320 T3037 T3036 appos [,]
R2321 T3038 T3039 nummod 20,]
R2322 T3039 T3036 conj ],]
R2323 T3128 T3122 prep upon,mediate
R2324 T3040 T2989 punct .,Upon
R2325 T3129 T3130 compound RIG-I,stimulation
R2326 T3130 T3128 pobj stimulation,upon
R2327 T3131 T3104 punct .,characterized
R2328 T3041 T3045 csubj Signaling,requires
R2329 T3132 T3165 prep On,shown
R2330 T3133 T3135 det the,hand
R2331 T3042 T3041 advmod downstream,Signaling
R2332 T3134 T3135 amod other,hand
R2333 T3135 T3132 pobj hand,On
R2334 T3136 T3165 punct ",",shown
R2335 T3137 T3165 advcl deubiquitinating,shown
R2336 T3138 T3137 dobj enzymes,deubiquitinating
R2337 T3139 T3138 punct (,enzymes
R2338 T3043 T3042 prep of,downstream
R2339 T3140 T3138 appos DUBs,enzymes
R2340 T3141 T3138 punct ),enzymes
R2341 T3142 T3138 punct ",",enzymes
R2342 T3044 T3043 pobj MAVS,of
R2343 T3143 T3144 amod such,as
R2344 T3144 T3138 prep as,enzymes
R2345 T3145 T3146 compound DUBA,[
R2346 T3045 T3045 ROOT requires,requires
R2347 T3146 T3144 pobj [,as
R2348 T3147 T3148 nummod 28,]
R2349 T3046 T3047 det the,action
R2350 T3148 T3146 conj ],[
R2351 T3149 T3148 punct ",",]
R2352 T3150 T3151 compound CYLD,[
R2353 T3047 T3045 dobj action,requires
R2354 T3151 T3148 conj [,]
R2355 T3152 T3153 compound 29,]
R2356 T3153 T3151 conj ],[
R2357 T3048 T3047 prep of,action
R2358 T3154 T3153 punct ",",]
R2359 T3155 T3153 conj [,]
R2360 T3156 T3157 nummod 30,]
R2361 T3049 T3052 amod various,enzymes
R2362 T3157 T3153 conj ],]
R2363 T3158 T3157 cc and,]
R2364 T3159 T3160 compound OTUB1/2,[
R2365 T3050 T3051 compound ubiquitin,modifying
R2366 T3160 T3157 conj [,]
R2367 T3161 T3162 nummod 31,]
R2368 T3162 T3157 conj ],]
R2369 T3051 T3052 amod modifying,enzymes
R2370 T3163 T3165 aux have,shown
R2371 T3164 T3165 auxpass been,shown
R2372 T3165 T3165 ROOT shown,shown
R2373 T3052 T3048 pobj enzymes,of
R2374 T3166 T3168 aux to,regulate
R2375 T3167 T3168 advmod negatively,regulate
R2376 T3053 T3052 punct ",",enzymes
R2377 T3168 T3165 xcomp regulate,shown
R2378 T3169 T3168 dobj RLR,regulate
R2379 T3170 T3165 advcl signaling,shown
R2380 T3054 T3059 nsubj which,regulate
R2381 T3171 T3170 prep by,signaling
R2382 T3172 T3173 advmod specifically,removing
R2383 T3173 T3171 pcomp removing,by
R2384 T3174 T3176 amod K63-linked,chains
R2385 T3175 T3176 compound polyubiquitin,chains
R2386 T3176 T3173 dobj chains,removing
R2387 T3055 T3056 preconj both,positively
R2388 T3177 T3173 prep from,removing
R2389 T3178 T3180 amod several,molecules
R2390 T3179 T3180 amod signaling,molecules
R2391 T3056 T3059 advmod positively,regulate
R2392 T3180 T3177 pobj molecules,from
R2393 T3181 T3165 punct .,shown
R2394 T3057 T3056 cc and,positively
R2395 T3058 T3056 conj negatively,positively
R2396 T3182 T3211 advmod Furthermore,inhibiting
R2397 T3059 T3052 relcl regulate,enzymes
R2398 T3183 T3211 punct ",",inhibiting
R2399 T3184 T3187 amod various,ligases
R2400 T3185 T3187 amod K48-specific,ligases
R2401 T3186 T3187 compound ubiquitin,ligases
R2402 T3060 T3059 dobj RIG-I,regulate
R2403 T3187 T3211 nsubj ligases,inhibiting
R2404 T3188 T3187 punct ",",ligases
R2405 T3189 T3190 amod such,as
R2406 T3061 T3063 amod mediated,transduction
R2407 T3190 T3187 prep as,ligases
R2408 T3191 T3192 compound AIP4,[
R2409 T3062 T3063 compound signal,transduction
R2410 T3192 T3190 pobj [,as
R2411 T3193 T3194 nummod 32,]
R2412 T3194 T3192 conj ],[
R2413 T3063 T3064 compound transduction,[
R2414 T3195 T3194 cc and,]
R2415 T3196 T3197 compound TRIAD3A,[
R2416 T3197 T3194 conj [,]
R2417 T3064 T3045 dobj [,requires
R2418 T3198 T3199 nummod 33,]
R2419 T3199 T3200 compound ],mark
R2420 T3200 T3192 conj mark,[
R2421 T3065 T3066 nummod 21,]
R2422 T3201 T3202 advmod respectively,MAVS
R2423 T3202 T3200 dobj MAVS,mark
R2424 T3203 T3202 cc and,MAVS
R2425 T3066 T3064 appos ],[
R2426 T3204 T3202 conj TRAF3,MAVS
R2427 T3205 T3200 prep for,mark
R2428 T3067 T3045 punct .,requires
R2429 T3206 T3208 amod proteasome,degradation
R2430 T3207 T3208 amod mediated,degradation
R2431 T3208 T3205 pobj degradation,for
R2432 T3209 T3187 punct ",",ligases
R2433 T3210 T3211 advmod thus,inhibiting
R2434 T3211 T3211 ROOT inhibiting,inhibiting
R2435 T3068 T3070 nmod K63-specific,ligases
R2436 T3212 T3213 advmod further,downstream
R2437 T3213 T3214 amod downstream,signaling
R2438 T3214 T3211 dobj signaling,inhibiting
R2439 T3215 T3211 punct .,inhibiting
R2440 T3069 T3070 compound ubiquitin,ligases
R2441 T3216 T3219 advmod Additionally,attachment
R2442 T3217 T3219 punct ",",attachment
R2443 T3218 T3219 det the,attachment
R2444 T3070 T3093 nsubjpass ligases,shown
R2445 T3219 T3219 ROOT attachment,attachment
R2446 T3220 T3219 prep of,attachment
R2447 T3221 T3223 amod K48-specific,chains
R2448 T3071 T3072 punct (,E3s
R2449 T3222 T3223 compound polyubiquitin,chains
R2450 T3223 T3220 pobj chains,of
R2451 T3224 T3219 prep to,attachment
R2452 T3072 T3070 appos E3s,ligases
R2453 T3073 T3070 punct ),ligases
R2454 T3074 T3070 punct ",",ligases
R2455 T3225 T3226 det the,IRF3
R2456 T3075 T3076 amod such,as
R2457 T3226 T3224 pobj IRF3,to
R2458 T3227 T3226 cc and,IRF3
R2459 T3076 T3070 prep as,ligases
R2460 T3228 T3226 conj IRF7,IRF3
R2461 T3229 T3230 compound transcription,factors
R2462 T3230 T3219 conj factors,attachment
R2463 T3077 T3080 nummod TRIM25,]
R2464 T3231 T3219 prep by,attachment
R2465 T3232 T3231 pobj E3s,by
R2466 T3233 T3234 amod such,as
R2467 T3078 T3080 nmod [,]
R2468 T3234 T3232 prep as,E3s
R2469 T3235 T3236 compound RAUL,[
R2470 T3079 T3080 nummod 22,]
R2471 T3236 T3234 pobj [,as
R2472 T3237 T3238 nummod 34,]
R2473 T3238 T3236 conj ],[
R2474 T3080 T3076 pobj ],as
R2475 T3239 T3238 punct ",",]
R2476 T3240 T3243 nummod TRIM21,]
R2477 T3081 T3080 cc and,]
R2478 T3241 T3243 nmod [,]
R2479 T3242 T3243 nummod 35,]
R2480 T3243 T3238 conj ],]
R2481 T3082 T3083 compound Riplet,[
R2482 T3244 T3243 cc and,]
R2483 T3245 T3246 compound RBCK1,[
R2484 T3246 T3243 conj [,]
R2485 T3247 T3248 nummod 36,]
R2486 T3248 T3253 nmod ],transduction
R2487 T3249 T3253 amod further,transduction
R2488 T3083 T3080 conj [,]
R2489 T3250 T3253 amod dampens,transduction
R2490 T3251 T3253 amod antiviral,transduction
R2491 T3252 T3253 compound signal,transduction
R2492 T3084 T3085 nummod 23,]
R2493 T3253 T3236 appos transduction,[
R2494 T3254 T3219 punct .,attachment
R2495 T3085 T3083 conj ],[
R2496 T3255 T3256 nsubj A20,is
R2497 T3256 T3256 ROOT is,is
R2498 T3257 T3259 det an,enzyme
R2499 T3258 T3259 amod ubiquitin-editing,enzyme
R2500 T3086 T3085 punct ",",]
R2501 T3259 T3256 attr enzyme,is
R2502 T3260 T3259 acl belonging,enzyme
R2503 T3087 T3089 nmod [,]
R2504 T3088 T3089 nummod 24,]
R2505 T3261 T3260 prep to,belonging
R2506 T3262 T3264 det the,family
R2507 T3089 T3085 conj ],]
R2508 T3263 T3264 compound OTU-domain,family
R2509 T3264 T3261 pobj family,to
R2510 T3265 T3264 prep of,family
R2511 T3090 T3093 punct ",",shown
R2512 T3266 T3265 pobj DUBs,of
R2513 T3267 T3256 punct .,is
R2514 T3268 T3272 advmod Interestingly,harbors
R2515 T3091 T3093 aux have,shown
R2516 T3269 T3272 punct ",",harbors
R2517 T3092 T3093 auxpass been,shown
R2518 T3270 T3272 nsubj A20,harbors
R2519 T3271 T3272 advmod also,harbors
R2520 T3272 T3272 ROOT harbors,harbors
R2521 T3093 T3093 ROOT shown,shown
R2522 T3273 T3275 amod atypical,finger
R2523 T3274 T3275 compound zinc,finger
R2524 T3275 T3281 nmod finger,activity
R2525 T3094 T3096 aux to,promote
R2526 T3276 T3281 amod dependent,activity
R2527 T3277 T3281 amod K48-specific,activity
R2528 T3278 T3281 nmod E3,activity
R2529 T3095 T3096 advmod directly,promote
R2530 T3279 T3281 compound ubiquitin,activity
R2531 T3280 T3281 compound ligase,activity
R2532 T3281 T3272 dobj activity,harbors
R2533 T3096 T3093 xcomp promote,shown
R2534 T3282 T3272 punct .,harbors
R2535 T3283 T3287 det Both,mechanisms
R2536 T3284 T3287 amod catalytic,mechanisms
R2537 T3285 T3284 cc and,catalytic
R2538 T3286 T3284 conj noncatalytic,catalytic
R2539 T3287 T3290 nsubjpass mechanisms,shown
R2540 T3097 T3098 compound RIG-I,activation
R2541 T3288 T3290 auxpass were,shown
R2542 T3289 T3290 advmod previously,shown
R2543 T3290 T3290 ROOT shown,shown
R2544 T3098 T3096 dobj activation,promote
R2545 T3291 T3293 aux to,involved
R2546 T3292 T3293 auxpass be,involved
R2547 T3099 T3093 punct .,shown
R2548 T3293 T3290 xcomp involved,shown
R2549 T3294 T3293 prep in,involved
R2550 T3295 T3297 det the,regulation
R2551 T3296 T3297 amod negative,regulation
R2552 T3100 T3104 prep In,characterized
R2553 T3297 T3294 pobj regulation,in
R2554 T3298 T3297 prep of,regulation
R2555 T3101 T3100 pobj addition,In
R2556 T3299 T3298 pobj proinflammatory,of
R2557 T3300 T3297 acl signaling,regulation
R2558 T3301 T3300 prep by,signaling
R2559 T3102 T3104 punct ",",characterized
R2560 T3302 T3301 pobj A20,by
R2561 T3303 T3300 prep in,signaling
R2562 T3304 T3303 pobj response,in
R2563 T3103 T3104 advmod well,characterized
R2564 T3305 T3304 prep to,response
R2565 T3306 T3307 amod multiple,receptors
R2566 T3307 T3305 pobj receptors,to
R2567 T3104 T3104 ROOT characterized,characterized
R2568 T3308 T3309 amod such,as
R2569 T3309 T3307 prep as,receptors
R2570 T3310 T3311 compound TNF,receptor
R2571 T3105 T3106 compound ubiquitin,ligases
R2572 T3311 T3309 pobj receptor,as
R2573 T3312 T3313 nsubj I,[
R2574 T3313 T3315 nmod [,]
R2575 T3106 T3104 dobj ligases,characterized
R2576 T3314 T3315 nummod 37,]
R2577 T3315 T3315 ROOT ],]
R2578 T3107 T3108 amod such,as
R2579 T3316 T3315 appos [,]
R2580 T3317 T3318 nummod 39,]
R2581 T3108 T3104 prep as,characterized
R2583 T3109 T3108 pobj TRAF6,as
R2587 T3110 T3112 nmod [,]
R2588 T3111 T3112 nummod 25,]
R2591 T3112 T3122 nsubj ],mediate
R2594 T3113 T3112 punct ",",]
R2598 T3114 T3112 conj [,]
R2602 T3115 T3116 nummod 26,]
R2605 T3116 T3112 conj ],]
R2610 T3117 T3116 cc and,]
R2613 T3118 T3119 compound TRAF3,[
R2614 T3119 T3116 conj [,]
R2616 T3120 T3121 nummod 27,]
R2617 T3121 T3122 npadvmod ],mediate
R2618 T3122 T3104 advcl mediate,characterized
R2621 T3123 T3124 advmod respectively,NF-κB
R2624 T3124 T3127 amod NF-κB,activation
R2628 T3125 T3124 cc and,NF-κB
R2632 T3126 T3124 conj IRF3,NF-κB
R2638 T3127 T3122 dobj activation,mediate
R2649 T3364 T3365 compound gene,targeting
R2650 T3365 T3365 ROOT targeting,targeting
R2651 T3366 T3365 prep of,targeting
R2652 T3367 T3366 pobj A20,of
R2653 T3421 T3422 compound A20,locus
R2654 T3368 T3365 prep in,targeting
R2655 T3369 T3371 amod specific,types
R2656 T3370 T3371 compound cell,types
R2657 T3422 T3419 pobj locus,in
R2658 T3371 T3368 pobj types,in
R2659 T3372 T3373 auxpass was,shown
R2660 T3373 T3365 conj shown,targeting
R2661 T3423 T3425 nsubjpass that,associated
R2662 T3374 T3376 aux to,associated
R2663 T3375 T3376 auxpass be,associated
R2664 T3424 T3425 auxpass are,associated
R2665 T3376 T3373 xcomp associated,shown
R2666 T3377 T3376 prep with,associated
R2667 T3378 T3384 nmod autoimmunity,]
R2668 T3425 T3416 relcl associated,identification
R2669 T3379 T3378 cc and,autoimmunity
R2670 T3380 T3381 amod chronic,inflammation
R2671 T3381 T3378 conj inflammation,autoimmunity
R2672 T3426 T3425 prep with,associated
R2673 T3382 T3378 conj [,autoimmunity
R2674 T3383 T3384 nummod 42,]
R2675 T3384 T3377 pobj ],with
R2676 T3427 T3429 amod several,diseases
R2677 T3385 T3384 appos [,]
R2678 T3386 T3387 nummod 48,]
R2679 T3387 T3384 conj ],]
R2680 T3428 T3429 amod autoimmune,diseases
R2681 T3388 T3373 punct ",",shown
R2682 T3389 T3390 advmod further,illustrating
R2683 T3390 T3373 advcl illustrating,shown
R2684 T3429 T3426 pobj diseases,with
R2685 T3391 T3393 mark that,is
R2686 T3392 T3393 nsubj A20,is
R2687 T3393 T3390 ccomp is,illustrating
R2688 T3394 T3396 det an,brake
R2689 T3395 T3396 amod important,brake
R2690 T3396 T3393 attr brake,is
R2691 T3430 T3429 cc and,diseases
R2692 T3431 T3432 amod chronic,inflammation
R2694 T3432 T3429 conj inflammation,diseases
R2698 T3433 T3435 nmod [,]
R2702 T3434 T3435 nummod 45,]
R2705 T3435 T3432 appos ],inflammation
R2709 T3436 T3413 punct .,illustrated
R2713 T3437 T3462 prep In,is
R2717 T3438 T3437 pobj contrast,In
R2721 T3439 T3438 prep to,contrast
R2723 T3440 T3443 poss its,function
R2724 T3441 T3442 advmod well,established
R2725 T3442 T3443 amod established,function
R2726 T3516 T3514 pobj response,in
R2727 T3443 T3439 pobj function,to
R2728 T3517 T3516 prep to,response
R2729 T3518 T3519 amod viral,infection
R2730 T3519 T3517 pobj infection,to
R2731 T3444 T3443 prep in,function
R2732 T3520 T3520 ROOT remains,remains
R2733 T3521 T3523 aux to,clarified
R2734 T3445 T3446 det the,regulation
R2735 T3522 T3523 auxpass be,clarified
R2736 T3523 T3520 xcomp clarified,remains
R2737 T3524 T3520 punct .,remains
R2738 T3525 T3552 advcl Using,provide
R2739 T3526 T3527 amod myeloid,cell
R2740 T3446 T3444 pobj regulation,in
R2741 T3527 T3531 nmod cell,mice
R2742 T3528 T3531 amod specific,mice
R2743 T3529 T3531 compound A20,mice
R2744 T3530 T3531 compound knockout,mice
R2745 T3447 T3446 prep of,regulation
R2746 T3531 T3525 dobj mice,Using
R2747 T3532 T3531 punct (,mice
R2748 T3533 T3531 appos A20myel-KO,mice
R2749 T3448 T3449 amod proinflammatory,responses
R2750 T3534 T3531 punct ),mice
R2751 T3535 T3538 nsubjpass that,generated
R2752 T3449 T3447 pobj responses,of
R2753 T3536 T3538 auxpass were,generated
R2754 T3537 T3538 advmod recently,generated
R2755 T3538 T3525 relcl generated,Using
R2756 T3450 T3443 punct ",",function
R2757 T3539 T3538 prep in,generated
R2758 T3540 T3541 poss our,lab
R2759 T3541 T3539 pobj lab,in
R2760 T3451 T3452 det the,role
R2761 T3542 T3541 cc and,lab
R2762 T3543 T3544 amod primary,cells
R2763 T3544 T3541 conj cells,lab
R2764 T3545 T3544 acl derived,cells
R2765 T3452 T3462 nsubj role,is
R2766 T3546 T3545 prep of,derived
R2767 T3547 T3548 det these,mice
R2768 T3548 T3546 pobj mice,of
R2769 T3453 T3452 prep of,role
R2770 T3549 T3552 punct ",",provide
R2771 T3550 T3552 nsubj we,provide
R2772 T3454 T3453 pobj A20,of
R2773 T3551 T3552 advmod here,provide
R2774 T3552 T3552 ROOT provide,provide
R2775 T3553 T3552 dobj evidence,provide
R2776 T3455 T3452 prep in,role
R2777 T3554 T3556 mark that,is
R2778 T3555 T3556 nsubj A20,is
R2779 T3556 T3553 acl is,evidence
R2780 T3557 T3560 det a,regulator
R2781 T3456 T3457 det the,regulation
R2782 T3558 T3560 amod crucial,regulator
R2783 T3559 T3560 amod negative,regulator
R2784 T3560 T3556 attr regulator,is
R2785 T3457 T3455 pobj regulation,in
R2786 T3561 T3560 prep of,regulator
R2787 T3562 T3566 amod IAV-induced,signaling
R2788 T3563 T3566 amod proinflammatory,signaling
R2789 T3564 T3563 cc and,proinflammatory
R2790 T3565 T3563 conj antiviral,proinflammatory
R2791 T3566 T3561 pobj signaling,of
R2792 T3458 T3457 prep of,regulation
R2793 T3567 T3566 prep in,signaling
R2794 T3568 T3567 pobj macrophages,in
R2795 T3569 T3552 punct .,provide
R2796 T3570 T3574 advmod Interestingly,show
R2797 T3459 T3461 amod antiviral,responses
R2798 T3571 T3574 punct ",",show
R2799 T3572 T3573 amod A20myel-KO,mice
R2800 T3460 T3461 amod immune,responses
R2801 T3573 T3574 nsubj mice,show
R2802 T3574 T3574 ROOT show,show
R2803 T3575 T3576 amod enhanced,survival
R2804 T3461 T3458 pobj responses,of
R2805 T3576 T3574 dobj survival,show
R2806 T3577 T3574 cc and,show
R2807 T3578 T3574 conj reduced,show
R2808 T3462 T3462 ROOT is,is
R2809 T3463 T3465 advmod less,described
R2810 T3579 T3578 dobj morbidity,reduced
R2811 T3580 T3578 prep in,reduced
R2812 T3464 T3465 advmod well,described
R2813 T3581 T3580 pobj response,in
R2814 T3582 T3581 prep to,response
R2815 T3583 T3585 compound IAV,infection
R2816 T3465 T3462 acomp described,is
R2817 T3584 T3585 compound lung,infection
R2818 T3585 T3582 pobj infection,to
R2819 T3586 T3578 prep compared,reduced
R2820 T3466 T3465 cc and,described
R2821 T3587 T3586 prep to,compared
R2822 T3588 T3590 amod wild,mice
R2823 T3467 T3465 conj limited,described
R2824 T3589 T3590 compound type,mice
R2825 T3590 T3587 pobj mice,to
R2826 T3591 T3574 punct .,show
R2827 T3468 T3467 prep to,limited
R2828 T3592 T3599 nsubjpass Protection,associated
R2829 T3593 T3592 prep against,Protection
R2830 T3469 T3470 det a,number
R2831 T3594 T3593 pobj IAV,against
R2832 T3595 T3594 prep in,IAV
R2833 T3596 T3597 compound A20myel-KO,mice
R2834 T3597 T3595 pobj mice,in
R2835 T3470 T3468 pobj number,to
R2836 T3598 T3599 auxpass is,associated
R2837 T3599 T3599 ROOT associated,associated
R2838 T3600 T3599 prep with,associated
R2839 T3601 T3602 amod increased,cytokine
R2840 T3602 T3600 pobj cytokine,with
R2841 T3603 T3602 cc and,cytokine
R2842 T3471 T3470 prep of,number
R2843 T3604 T3605 compound chemokine,production
R2844 T3605 T3602 conj production,cytokine
R2845 T3606 T3605 punct ",",production
R2846 T3472 T3470 prep in,number
R2847 T3607 T3608 amod augmented,recruitment
R2848 T3608 T3602 conj recruitment,cytokine
R2849 T3609 T3608 prep of,recruitment
R2850 T3473 T3474 amod vitro,studies
R2851 T3610 T3612 amod innate,cells
R2852 T3611 T3612 amod immune,cells
R2853 T3474 T3472 pobj studies,in
R2854 T3612 T3609 pobj cells,of
R2855 T3475 T3467 advcl using,limited
R2856 T3476 T3475 dobj overexpression,using
R2857 T3613 T3614 amod such,as
R2858 T3614 T3612 prep as,cells
R2859 T3477 T3475 cc or,using
R2860 T3615 T3614 pobj neutophils,as
R2861 T3616 T3615 cc and,neutophils
R2862 T3617 T3618 amod alveolar,macrophages
R2863 T3478 T3475 conj silencing,using
R2864 T3618 T3615 conj macrophages,neutophils
R2865 T3619 T3618 punct ",",macrophages
R2866 T3620 T3618 cc and,macrophages
R2867 T3479 T3478 prep in,silencing
R2868 T3621 T3623 amod enhanced,clearance
R2869 T3622 T3623 amod viral,clearance
R2870 T3623 T3618 conj clearance,macrophages
R2871 T3480 T3482 amod specific,lines
R2872 T3624 T3599 punct .,associated
R2873 T3625 T3626 det These,results
R2874 T3481 T3482 compound cell,lines
R2875 T3626 T3627 nsubj results,suggest
R2876 T3627 T3627 ROOT suggest,suggest
R2877 T3628 T3644 mark that,have
R2878 T3482 T3479 pobj lines,in
R2879 T3629 T3644 csubj boosting,have
R2880 T3630 T3633 det the,response
R2881 T3483 T3462 punct ",",is
R2882 T3631 T3633 amod innate,response
R2883 T3632 T3633 amod immune,response
R2884 T3633 T3629 dobj response,boosting
R2885 T3484 T3462 advcl indicating,is
R2886 T3634 T3633 prep to,response
R2887 T3635 T3634 pobj IAV,to
R2888 T3636 T3629 prep by,boosting
R2889 T3637 T3636 pcomp targeting,by
R2890 T3638 T3639 amod A20,activity
R2891 T3639 T3637 dobj activity,targeting
R2892 T3485 T3488 mark that,regulate
R2893 T3640 T3637 prep in,targeting
R2894 T3641 T3642 amod myeloid,cells
R2895 T3642 T3640 pobj cells,in
R2896 T3486 T3488 nsubj A20,regulate
R2897 T3643 T3644 aux might,have
R2898 T3644 T3627 ccomp have,suggest
R2899 T3487 T3488 aux may,regulate
R2900 T3645 T3646 amod therapeutic,potential
R2901 T3646 T3644 dobj potential,have
R2902 T3647 T3627 punct .,suggest
R2903 T3488 T3484 ccomp regulate,indicating
R2904 T3489 T3488 dobj RIG-I,regulate
R2905 T3490 T3489 punct -,RIG-I
R2906 T3491 T3489 cc and,RIG-I
R2907 T3492 T3493 amod TLR3-induced,signaling
R2908 T3493 T3488 dobj signaling,regulate
R2909 T3494 T3501 prep to,[
R2910 T3495 T3494 pobj NF-κB,to
R2911 T3496 T3495 cc and,NF-κB
R2912 T3497 T3498 compound IRF-3,[
R2913 T3498 T3495 conj [,NF-κB
R2914 T3499 T3500 nummod 49,]
R2915 T3500 T3501 nmod ],[
R2916 T3501 T3488 xcomp [,regulate
R2917 T3502 T3503 nummod 52,]
R2918 T3503 T3501 dobj ],[
R2919 T3504 T3462 punct .,is
R2920 T3505 T3520 advmod However,remains
R2921 T3506 T3520 punct ",",remains
R2922 T3507 T3508 det the,precise
R2923 T3508 T3520 nsubj precise,remains
R2924 T3509 T3508 prep in,precise
R2925 T3510 T3511 compound vivo,role
R2926 T3511 T3509 pobj role,in
R2927 T3512 T3511 prep of,role
R2928 T3513 T3512 pobj A20,of
R2929 T3514 T3511 prep in,role
R2930 T3515 T3516 det the,response
R2599 T3329 T3323 conj ],]
R2600 T3330 T3290 punct .,shown
R2601 T3331 T3333 det The,role
R2603 T3332 T3333 amod anti-inflammatory,role
R2615 T3340 T3341 det the,fact
R2582 T3318 T3315 conj ],]
R2584 T3319 T3318 punct ",",]
R2585 T3320 T3323 nummod TLR4,]
R2586 T3321 T3323 nmod [,]
R2589 T3322 T3323 nummod 40,]
R2590 T3323 T3318 conj ],]
R2592 T3324 T3323 punct ",",]
R2593 T3325 T3323 cc and,]
R2595 T3326 T3327 compound IL-1R,[
R2596 T3327 T3323 conj [,]
R2597 T3328 T3329 nummod 41,]
R2604 T3333 T3338 nsubjpass role,demonstrated
R2606 T3334 T3333 prep of,role
R2607 T3335 T3334 pobj A20,of
R2608 T3336 T3338 auxpass is,demonstrated
R2609 T3337 T3338 advmod clearly,demonstrated
R2611 T3338 T3338 ROOT demonstrated,demonstrated
R2612 T3339 T3338 agent by,demonstrated
R2619 T3341 T3339 pobj fact,by
R2620 T3342 T3346 mark that,die
R2622 T3343 T3345 nummod A20,mice
R2623 T3344 T3345 amod deficient,mice
R2625 T3345 T3346 nsubj mice,die
R2626 T3346 T3341 acl die,fact
R2627 T3347 T3348 advmod early,after
R2629 T3348 T3346 prep after,die
R2630 T3349 T3348 pobj birth,after
R2631 T3350 T3341 amod due,fact
R2633 T3351 T3350 prep to,due
R2634 T3352 T3354 amod severe,inflammation
R2635 T3353 T3354 amod multi-organ,inflammation
R2636 T3354 T3351 pobj inflammation,to
R2637 T3355 T3354 cc and,inflammation
R2639 T3356 T3354 conj cachexia,inflammation
R2640 T3357 T3359 nmod [,]
R2641 T3358 T3359 nummod 37,]
R2643 T3359 T3356 appos ],cachexia
R2644 T3360 T3338 punct .,demonstrated
R2645 T3361 T3362 advmod More,recently
R2646 T3362 T3365 advmod recently,targeting
R2647 T3363 T3365 punct ",",targeting
R2642 T3419 T3418 prep in,polymorphisms
R2648 T3420 T3422 det the,locus
R2693 T3397 T3396 prep on,brake
R2695 T3398 T3400 det the,response
R2696 T3399 T3400 amod inflammatory,response
R2697 T3400 T3397 pobj response,on
R2699 T3401 T3373 punct .,shown
R2700 T3402 T3403 det The,relevance
R2701 T3403 T3413 nsubjpass relevance,illustrated
R2703 T3404 T3403 prep of,relevance
R2704 T3405 T3406 det these,findings
R2706 T3406 T3404 pobj findings,of
R2707 T3407 T3403 prep for,relevance
R2708 T3408 T3409 amod human,disease
R2710 T3409 T3407 pobj disease,for
R2711 T3410 T3413 aux has,illustrated
R2712 T3411 T3413 advmod recently,illustrated
R2714 T3412 T3413 auxpass been,illustrated
R2715 T3413 T3413 ROOT illustrated,illustrated
R2716 T3414 T3413 prep through,illustrated
R2718 T3415 T3416 det the,identification
R2719 T3416 T3414 pobj identification,through
R2720 T3417 T3416 prep of,identification
R2722 T3418 T3417 pobj polymorphisms,of

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T3988 6511-6514 Protein denotes A20
T3987 5957-5960 Protein denotes A20
T3986 5723-5726 Protein denotes A20
T3985 5669-5674 Protein denotes IRF-3
T3984 5659-5664 Protein denotes NF-κB
T3983 5633-5637 Protein denotes TLR3
T3982 5605-5608 Protein denotes A20
T3981 5412-5415 Protein denotes A20
T3980 5213-5222 Protein denotes A20 locus
T3979 5026-5029 Protein denotes A20
T3978 4892-4895 Protein denotes A20
T3977 4715-4718 Protein denotes A20
T3976 4632-4646 Protein denotes TNF receptor I
T3975 4586-4589 Protein denotes A20
T3974 4420-4436 Protein denotes ubiquitin ligase
T3973 4417-4419 Protein denotes E3
T3972 4356-4359 Protein denotes A20
T3971 4314-4331 Protein denotes OTU-domain family
T3970 4272-4281 Protein denotes ubiquitin
T3969 4262-4265 Protein denotes A20
T3968 4204-4209 Protein denotes RBCK1
T3967 4135-4161 Protein denotes IRF7 transcription factors
T3966 4126-4130 Protein denotes IRF3
T3965 4085-4118 Protein denotes K48-specific polyubiquitin chains
T3964 3994-4005 Protein_catabolism denotes degradation
T3963 3994-4005 Protein_catabolism denotes degradation
T3962 3964-3969 Protein denotes TRAF3
T3961 3870-3900 Protein denotes K48-specific ubiquitin ligases
T3960 3794-3807 Protein denotes polyubiquitin
T3959 3530-3537 Positive_regulation denotes mediate
T3958 3530-3537 Positive_regulation denotes mediate
T3957 3566-3576 Positive_regulation denotes activation
T3956 3566-3576 Positive_regulation denotes activation
T3946 3305-3335 Protein denotes K63-specific ubiquitin ligases
T3945 3264-3269 Protein denotes RIG-I
T3944 3189-3198 Protein denotes ubiquitin
T3943 3153-3157 Protein denotes MAVS
T3942 2901-2910 Binding denotes associate
T3941 2866-2873 Binding denotes binding
T3940 2866-2873 Binding denotes binding
T3939 2866-2873 Binding denotes binding
T3938 2920-2931 Protein denotes CARD domain
T3937 2895-2900 Protein denotes RIG-I
T3936 2879-2891 Protein denotes CARD domains
T3935 2751-2770 Protein denotes DExD/H box helicase
T3934 2477-2486 Negative_regulation denotes deficient
T3933 2472-2476 Protein denotes TLR3
T3932 2355-2360 Protein denotes RIG-I
T3931 2145-2150 Protein denotes RIG-I
T3930 2136-2140 Protein denotes TLR3
T3929 1281-1290 Gene_expression denotes producing
T3928 1270-1280 Protein denotes type I IFN
T3927 1153-1163 Gene_expression denotes containing
T3926 1153-1163 Gene_expression denotes containing
T3925 1196-1201 Protein denotes IFI16
T3924 1140-1152 Protein denotes PYHIN domain
T3923 1118-1122 Protein denotes TLR9
T3922 886-890 Protein denotes RLRs
T3921 915-919 Protein denotes NLRs
T3920 1022-1026 Protein denotes MDA5
T3919 1015-1020 Protein denotes RIG-I
T3918 1009-1013 Protein denotes TLR3
T3917 979-983 Protein denotes Nod2
T3916 973-977 Protein denotes TLR8
T3915 967-971 Protein denotes TLR7
T3914 895-913 Protein denotes Nod-like receptors
T3913 864-884 Protein denotes RIG-I-like receptors
T3912 829-833 Protein denotes TLRs
T3911 798-827 Protein denotes Endosomal Toll-like receptors
T3910 339-346 Positive_regulation denotes induces
T3909 339-346 Positive_regulation denotes induces
T3908 339-346 Positive_regulation denotes induces
T3907 339-346 Positive_regulation denotes induces
T3906 339-346 Positive_regulation denotes induces
T3905 339-346 Positive_regulation denotes induces
T3904 339-346 Positive_regulation denotes induces
T3903 351-361 Gene_expression denotes production
T3902 351-361 Gene_expression denotes production
T3901 351-361 Gene_expression denotes production
T3900 351-361 Gene_expression denotes production
T3899 351-361 Gene_expression denotes production
T3898 351-361 Gene_expression denotes production
T3897 351-361 Gene_expression denotes production
T3896 603-611 Protein denotes IRF7 [1]
T3895 594-598 Protein denotes IRF3
T3894 588-592 Protein denotes AP-1
T3893 581-586 Protein denotes NF-κB
T3892 471-476 Protein denotes IFN-β
T3891 460-465 Protein denotes IFN-α
T3890 446-458 Protein denotes interferon-α
T3889 426-444 Protein denotes type I interferons
T3888 416-420 Protein denotes IL-1
T3887 407-411 Protein denotes IL-6
T3886 402-405 Protein denotes TNF
T3885 244-247 Protein denotes PRR
T3955 3582-3587 Protein denotes RIG-I
T3954 3561-3565 Protein denotes IRF3
T3953 3551-3556 Protein denotes NF-κB
T3952 3472-3489 Protein denotes ubiquitin ligases
T3951 3428-3438 Positive_regulation denotes activation
T3950 3414-3421 Gene_expression denotes promote
T3949 3414-3421 Gene_expression denotes promote
T3948 3422-3427 Protein denotes RIG-I
T3947 3337-3340 Protein denotes E3s
T3884 213-242 Protein denotes pattern recognition receptors
R3002 T3886 T3897 themeOf TNF,production
R3003 T3887 T3898 themeOf IL-6,production
R3004 T3888 T3899 themeOf IL-1,production
R3005 T3889 T3900 themeOf type I interferons,production
R3006 T3890 T3901 themeOf interferon-α,production
R3007 T3891 T3902 themeOf IFN-α,production
R3008 T3892 T3903 themeOf IFN-β,production
R3009 T3928 T3929 themeOf type I IFN,producing
R3010 T3897 T3904 themeOf production,induces
R3011 T3933 T3934 themeOf TLR3,deficient
R3012 T3898 T3905 themeOf production,induces
R3013 T3936 T3939 themeOf CARD domains,binding
R3014 T3936 T3941 themeOf CARD domains,binding
R3015 T3937 T3940 themeOf RIG-I,binding
R3016 T3937 T3941 themeOf RIG-I,binding
R3017 T3937 T3942 themeOf RIG-I,associate
R3018 T3938 T3942 themeOf CARD domain,associate
R3019 T3899 T3906 themeOf production,induces
R3020 T3900 T3907 themeOf production,induces
R3021 T3901 T3908 themeOf production,induces
R3022 T3946 T3949 themeOf K63-specific ubiquitin ligases,promote
R3023 T3947 T3950 themeOf E3s,promote
R3024 T3902 T3909 themeOf production,induces
R3025 T3948 T3951 themeOf RIG-I,activation
R3026 T3903 T3910 themeOf production,induces
R3027 T3924 T3926 themeOf PYHIN domain,containing
R3028 T3953 T3956 themeOf NF-κB,activation
R3029 T3954 T3957 themeOf IRF3,activation
R3030 T3956 T3958 themeOf activation,mediate
R3031 T3957 T3959 themeOf activation,mediate
R3032 T3958 T3952 Cause mediate,ubiquitin ligases
R3033 T3959 T3952 Cause mediate,ubiquitin ligases
R3034 T3961 T3963 themeOf K48-specific ubiquitin ligases,degradation
R3035 T3962 T3964 themeOf TRAF3,degradation
R3036 T3925 T3927 themeOf IFI16,containing

testone

Id Subject Object Predicate Lexical cue
T783 4764-4773 Negative_regulation denotes deficient
T782 3994-4005 Protein_catabolism denotes degradation
T781 3566-3576 Positive_regulation denotes activation
T780 3111-3117 Entity denotes domain
T779 3014-3026 Localization denotes translocates
T778 2925-2931 Entity denotes domain
T777 2901-2910 Binding denotes associate
T776 2884-2891 Entity denotes domains
T775 2866-2873 Binding denotes binding
T774 2477-2486 Negative_regulation denotes deficient
T773 2407-2416 Negative_regulation denotes deficient
T772 1281-1290 Gene_expression denotes producing
T771 5669-5674 Protein denotes IRF-3
T770 5633-5637 Protein denotes TLR3
T769 5622-5627 Protein denotes RIG-I
T768 4673-4678 Protein denotes IL-1R
T767 4658-4662 Protein denotes TLR4
T766 4632-4646 Protein denotes TNF receptor I
T765 4204-4209 Protein denotes RBCK1
T764 4188-4194 Protein denotes TRIM21
T763 4177-4181 Protein denotes RAUL
T762 4135-4139 Protein denotes IRF7
T761 4126-4130 Protein denotes IRF3
T760 3964-3969 Protein denotes TRAF3
T759 3955-3959 Protein denotes MAVS
T758 3924-3931 Protein denotes TRIAD3A
T757 3910-3914 Protein denotes AIP4
T756 3744-3747 Protein denotes RLR
T755 3672-3676 Protein denotes CYLD
T754 3661-3665 Protein denotes DUBA
T753 3582-3587 Protein denotes RIG-I
T752 3561-3565 Protein denotes IRF3
T751 3519-3524 Protein denotes TRAF3
T750 3498-3503 Protein denotes TRAF6
T749 3422-3427 Protein denotes RIG-I
T748 3367-3373 Protein denotes Riplet
T747 3351-3357 Protein denotes TRIM25
T746 3264-3269 Protein denotes RIG-I
T745 3153-3157 Protein denotes MAVS
T744 2970-2976 Protein denotes Cardif
T743 2964-2968 Protein denotes VISA
T742 2957-2962 Protein denotes IPS-1
T741 2939-2943 Protein denotes MAVS
T740 2895-2900 Protein denotes RIG-I
T739 2723-2728 Protein denotes RIG-I
T738 2472-2476 Protein denotes TLR3
T737 2401-2406 Protein denotes RIG-I
T736 2355-2360 Protein denotes RIG-I
T735 2145-2150 Protein denotes RIG-I
T734 2136-2140 Protein denotes TLR3
T733 1196-1201 Protein denotes IFI16
T732 1173-1177 Protein denotes AIM2
T731 1124-1127 Protein denotes DAI
T730 1118-1122 Protein denotes TLR9
T729 1022-1026 Protein denotes MDA5
T728 1015-1020 Protein denotes RIG-I
T727 1009-1013 Protein denotes TLR3
T726 979-983 Protein denotes Nod2
T725 973-977 Protein denotes TLR8
T724 967-971 Protein denotes TLR7
T723 603-607 Protein denotes IRF7
T722 594-598 Protein denotes IRF3
T721 471-476 Protein denotes IFN-β
T720 460-465 Protein denotes IFN-α
T719 446-458 Protein denotes interferon-α
T718 416-420 Protein denotes IL-1
T717 407-411 Protein denotes IL-6
T716 402-405 Protein denotes TNF
R526 T752 T781 themeOf IRF3,activation
R518 T720 T718 equivalentTo IFN-α,IL-1
R519 T720 T717 equivalentTo IFN-α,IL-6
R520 T720 T716 equivalentTo IFN-α,TNF
R521 T737 T773 themeOf RIG-I,deficient
R522 T738 T774 themeOf TLR3,deficient
R523 T742 T779 themeOf IPS-1,translocates
R524 T743 T779 themeOf VISA,translocates
R525 T744 T779 themeOf Cardif,translocates
R527 T753 T781 causeOf RIG-I,activation
R528 T757 T782 themeOf AIP4,degradation
R529 T758 T782 themeOf TRIAD3A,degradation
R530 T759 T782 themeOf MAVS,degradation