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PMC:3291650 / 12452-15207 JSONTXT

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test3

Id Subject Object Predicate Lexical cue
T4722 2716-2720 Protein denotes IRF3
T4721 2692-2697 Protein denotes RIG-I
T4720 2498-2502 Protein denotes IFNβ
T4719 2490-2493 Protein denotes TNF
T4718 2484-2488 Protein denotes IL-6
T4717 2463-2472 Positive_regulation denotes increased
T4716 2413-2417 Protein denotes IRF3
T4715 2357-2361 Protein denotes IFNβ
T4714 2343-2353 Gene_expression denotes expression
T4713 2331-2338 Regulation denotes control
T4712 2326-2330 Protein denotes IRF3
T4711 2307-2310 Protein denotes TNF
T4710 2298-2302 Protein denotes IL-6
T4709 2284-2294 Gene_expression denotes expression
T4708 2271-2279 Regulation denotes controls
T4707 2209-2218 Negative_regulation denotes deficient
T4706 2143-2156 Localization denotes translocation
T4705 2135-2142 Entity denotes nuclear
T4704 2130-2134 Protein denotes IRF3
T4703 2125-2128 Protein denotes p65
T4702 2003-2018 Phosphorylation denotes phosphorylation
T4701 1998-2002 Protein denotes IRF3
T4700 1967-1981 Phosphorylation denotes phosphorylated
T4699 1898-1905 Entity denotes nucleus
T4698 1877-1890 Localization denotes translocation
T4697 1823-1827 Protein denotes IKKε
T4696 1814-1818 Protein denotes TBK1
T4695 1725-1740 Phosphorylation denotes phosphorylation
T4694 1710-1719 Positive_regulation denotes activated
T4693 1690-1694 Protein denotes IRF3
T4692 1556-1564 Positive_regulation denotes enhanced
T4691 1534-1537 Protein denotes p65
T4690 1513-1526 Localization denotes translocation
T4689 1505-1512 Entity denotes nuclear
T4688 1474-1478 Protein denotes IκBα
T4687 1459-1470 Protein_catabolism denotes degradation
T4686 1449-1458 Positive_regulation denotes sustained
T4685 1429-1444 Phosphorylation denotes phosphorylation
T4684 1419-1428 Positive_regulation denotes increased
T4683 1354-1363 Negative_regulation denotes deficient
T4682 1075-1085 Gene_expression denotes expression
T4681 1069-1074 Positive_regulation denotes rapid
T4680 1057-1064 Positive_regulation denotes induced
T4679 964-968 Protein denotes IRF3
T4678 939-943 Protein denotes TLR3
T4677 854-858 Protein denotes MDA5
T4676 836-841 Protein denotes RIG-I
T4675 818-822 Binding denotes bind
T4674 648-653 Protein denotes RIG-I
T4673 479-486 Regulation denotes control
T4672 446-456 Gene_expression denotes expressing
T4671 159-168 Negative_regulation denotes deficient
T4670 53-58 Protein denotes RIG-I
T4624 2716-2720 Protein denotes IRF3
T4623 2692-2697 Protein denotes RIG-I
T4622 2498-2502 Protein denotes IFNβ
T4621 2490-2493 Protein denotes TNF
T4620 2484-2488 Protein denotes IL-6
T4619 2413-2417 Protein denotes IRF3
T4618 2357-2361 Protein denotes IFNβ
T4617 2326-2330 Protein denotes IRF3
T4616 2307-2310 Protein denotes TNF
T4615 2298-2302 Protein denotes IL-6
T4614 2130-2134 Protein denotes IRF3
T4613 2125-2128 Protein denotes p65
T4612 1998-2002 Protein denotes IRF3
T4611 1823-1827 Protein denotes IKKε
T4610 1814-1818 Protein denotes TBK1
T4609 1690-1694 Protein denotes IRF3
T4608 1534-1537 Protein denotes p65
T4607 1474-1478 Protein denotes IκBα
T4606 964-968 Protein denotes IRF3
T4605 939-943 Protein denotes TLR3
T4604 854-858 Protein denotes MDA5
T4603 836-841 Protein denotes RIG-I
T4602 648-653 Protein denotes RIG-I
T4601 53-58 Protein denotes RIG-I
R3189 T4674 T4675 themeOf RIG-I,bind
R3190 T4676 T4675 themeOf RIG-I,bind
R3191 T4677 T4675 themeOf MDA5,bind
R3192 T4681 T4680 themeOf rapid,induced
R3193 T4682 T4680 themeOf expression,induced
R3194 T4682 T4681 themeOf expression,rapid
R3195 T4683 T4684 causeOf deficient,increased
R3196 T4683 T4686 causeOf deficient,sustained
R3197 T4685 T4684 themeOf phosphorylation,increased
R3198 T4685 T4686 causeOf phosphorylation,sustained
R3199 T4687 T4686 themeOf degradation,sustained
R3200 T4688 T4687 themeOf IκBα,degradation
R3201 T4688 T4685 themeOf IκBα,phosphorylation
R3202 T4689 T4690 locationOf nuclear,translocation
R3203 T4690 T4692 themeOf translocation,enhanced
R3204 T4691 T4690 themeOf p65,translocation
R3205 T4693 T4698 themeOf IRF3,translocation
R3206 T4693 T4694 themeOf IRF3,activated
R3207 T4697 T4698 themeOf IKKε,translocation
R3208 T4699 T4698 locationOf nucleus,translocation
R3209 T4701 T4702 themeOf IRF3,phosphorylation
R3210 T4703 T4706 themeOf p65,translocation
R3211 T4704 T4706 themeOf IRF3,translocation
R3212 T4705 T4706 locationOf nuclear,translocation
R3213 T4709 T4708 themeOf expression,controls
R3214 T4710 T4709 themeOf IL-6,expression
R3215 T4711 T4709 themeOf TNF,expression
R3216 T4712 T4713 causeOf IRF3,control
R3217 T4712 T4709 themeOf IRF3,expression
R3218 T4714 T4713 themeOf expression,control
R3219 T4715 T4714 themeOf IFNβ,expression
R3220 T4718 T4717 themeOf IL-6,increased
R3221 T4719 T4717 themeOf TNF,increased
R3222 T4720 T4717 themeOf IFNβ,increased

2_test

Id Subject Object Predicate Lexical cue
22396652-11009421-98461852 283-285 11009421 denotes 37
22396652-20530205-98461853 400-402 20530205 denotes 56
22396652-21841782-98461854 626-628 21841782 denotes 48
22396652-18591409-98461855 860-862 18591409 denotes 57
22396652-15210742-98461856 1829-1831 15210742 denotes 58
22396652-9566918-98461857 1907-1909 9566918 denotes 59

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T5660 1666-1670 NN denotes type
T5659 1661-1665 JJ denotes wild
T5658 1658-1660 TO denotes to
T5657 1649-1657 VB denotes compared
T5656 1642-1648 NN denotes points
T5655 1637-1641 NN denotes time
T5654 1629-1636 JJ denotes earlier
T5653 1626-1628 IN denotes at
T5652 1618-1625 NN denotes maximum
T5651 1616-1617 DT denotes a
T5650 1607-1615 VB denotes reaching
T5649 1605-1606 -COMMA- denotes ,
T5648 1601-1605 NN denotes BMDM
T5647 1590-1600 NN denotes A20myel-KO
T5646 1578-1589 VB denotes transfected
T5645 1576-1577 -RRB- denotes )
T5644 1575-1576 NN denotes C
T5643 1574-1575 SYM denotes :
T5642 1573-1574 NN denotes I
T5641 1572-1573 -LRB- denotes (
T5640 1568-1572 NN denotes poly
T5639 1565-1567 IN denotes in
T5638 1556-1564 VB denotes enhanced
T5637 1552-1555 VB denotes was
T5636 1544-1551 NN denotes subunit
T5635 1538-1543 NN denotes NF-κB
T5634 1534-1537 NN denotes p65
T5633 1530-1533 DT denotes the
T5632 1527-1529 IN denotes of
T5631 1513-1526 NN denotes translocation
T5630 1505-1512 JJ denotes nuclear
T5629 1503-1504 -COMMA- denotes ,
T5628 1492-1503 RB denotes Furthermore
T5627 1489-1490 -RRB- denotes )
T5626 1487-1489 NN denotes 1B
T5625 1480-1486 NN denotes figure
T5624 1479-1480 -LRB- denotes (
T5623 1474-1478 NN denotes IκBα
T5622 1471-1473 IN denotes of
T5621 1459-1470 NN denotes degradation
T5620 1449-1458 JJ denotes sustained
T5619 1445-1448 CC denotes and
T5618 1429-1444 NN denotes phosphorylation
T5617 1419-1428 VB denotes increased
T5616 1416-1418 IN denotes by
T5615 1406-1415 VB denotes indicated
T5614 1403-1405 IN denotes as
T5613 1392-1402 NN denotes activation
T5612 1386-1391 NN denotes NF-κB
T5611 1377-1385 VB denotes enhanced
T5610 1370-1376 VB denotes showed
T5609 1364-1369 NN denotes cells
T5608 1354-1363 JJ denotes deficient
T5607 1350-1353 NN denotes A20
T5606 1348-1349 -COMMA- denotes ,
T5605 1344-1348 NN denotes BMBM
T5604 1339-1343 NN denotes type
T5603 1334-1338 JJ denotes wild
T5602 1331-1333 TO denotes to
T5601 1322-1330 VB denotes Compared
T5600 1308-1320 NN denotes transfection
T5599 1306-1307 -RRB- denotes )
T5598 1305-1306 NN denotes C
T5597 1304-1305 SYM denotes :
T5596 1303-1304 NN denotes I
T5595 1302-1303 -LRB- denotes (
T5594 1298-1302 NN denotes poly
T5593 1293-1297 IN denotes upon
T5592 1280-1292 NN denotes modification
T5591 1272-1279 JJ denotes unknown
T5590 1268-1271 RB denotes yet
T5589 1266-1267 DT denotes a
T5588 1256-1265 VB denotes undergoes
T5587 1252-1255 NN denotes A20
T5586 1247-1251 IN denotes that
T5585 1236-1246 VB denotes indicating
T5584 1234-1235 -COMMA- denotes ,
T5583 1226-1234 VB denotes observed
T5582 1221-1225 VB denotes were
T5581 1217-1220 NN denotes A20
T5580 1214-1216 IN denotes of
T5579 1208-1213 NN denotes forms
T5578 1198-1207 JJ denotes migrating
T5577 1191-1197 JJ denotes slower
T5576 1182-1190 RB denotes slightly
T5575 1180-1181 -COMMA- denotes ,
T5574 1174-1180 NN denotes points
T5573 1169-1173 NN denotes time
T5572 1163-1168 JJ denotes early
T5571 1160-1162 IN denotes At
T5570 1157-1158 -RRB- denotes )
T5569 1152-1157 NN denotes panel
T5568 1146-1151 JJ denotes upper
T5567 1144-1145 -COMMA- denotes ,
T5566 1142-1144 NN denotes 1B
T5565 1135-1141 NN denotes figure
T5564 1134-1135 -LRB- denotes (
T5563 1129-1133 NN denotes BMDM
T5562 1118-1128 NN denotes A20myel-KO
T5561 1115-1117 IN denotes in
T5560 1111-1114 RB denotes not
T5559 1107-1110 CC denotes but
T5558 1105-1106 -COMMA- denotes ,
T5557 1101-1105 NN denotes type
T5556 1096-1100 JJ denotes wild
T5555 1093-1095 IN denotes in
T5554 1089-1092 NN denotes A20
T5553 1086-1088 IN denotes of
T5552 1075-1085 NN denotes expression
T5551 1069-1074 JJ denotes rapid
T5550 1065-1068 DT denotes the
T5549 1057-1064 VB denotes induced
T5548 1044-1056 NN denotes transfection
T5547 1042-1043 -RRB- denotes )
T5546 1041-1042 NN denotes C
T5545 1040-1041 SYM denotes :
T5544 1039-1040 NN denotes I
T5543 1038-1039 -LRB- denotes (
T5542 1034-1038 NN denotes poly
T5541 1032-1033 -COMMA- denotes ,
T5540 1024-1032 VB denotes expected
T5539 1021-1023 IN denotes As
T5538 1018-1019 -RRB- denotes )
T5537 1013-1018 VB denotes shown
T5536 1009-1012 RB denotes not
T5535 1004-1008 NN denotes data
T5534 1003-1004 -LRB- denotes (
T5533 992-1002 NN denotes production
T5532 983-991 NN denotes cytokine
T5531 980-982 CC denotes or
T5530 969-979 NN denotes activation
T5529 964-968 NN denotes IRF3
T5528 960-963 CC denotes and
T5527 954-959 NN denotes NF-κB
T5526 944-953 JJ denotes dependent
T5525 939-943 NN denotes TLR3
T5524 927-938 JJ denotes significant
T5523 920-926 VB denotes induce
T5522 917-919 TO denotes to
T5521 910-916 JJ denotes unable
T5520 906-909 VB denotes was
T5519 904-905 -RRB- denotes )
T5518 903-904 NN denotes C
T5517 902-903 SYM denotes :
T5516 901-902 NN denotes I
T5515 900-901 -LRB- denotes (
T5514 896-900 NN denotes poly
T5513 893-895 IN denotes of
T5512 879-892 NN denotes concentration
T5511 874-878 DT denotes this
T5510 872-873 -COMMA- denotes ,
T5509 868-872 NN denotes note
T5508 865-867 IN denotes Of
T5507 862-863 -RRB- denotes ]
T5506 860-862 CD denotes 57
T5505 859-860 -LRB- denotes [
T5504 854-858 NN denotes MDA5
T5503 849-853 IN denotes than
T5502 842-848 RB denotes rather
T5501 836-841 NN denotes RIG-I
T5500 827-835 VB denotes activate
T5499 823-826 CC denotes and
T5498 818-822 VB denotes bind
T5497 803-817 RB denotes preferentially
T5496 800-802 TO denotes to
T5495 794-799 VB denotes known
T5494 791-793 VB denotes is
T5493 785-790 WDT denotes which
T5492 783-784 -COMMA- denotes ,
T5491 782-783 -RRB- denotes )
T5490 781-782 NN denotes C
T5489 780-781 SYM denotes :
T5488 779-780 NN denotes I
T5487 778-779 -LRB- denotes (
T5486 774-778 NN denotes poly
T5485 772-773 -RRB- denotes )
T5484 769-772 NN denotes LMW
T5483 768-769 -LRB- denotes (
T5482 761-767 NN denotes weight
T5481 751-760 JJ denotes molecular
T5480 747-750 JJ denotes low
T5479 744-746 IN denotes of
T5478 736-743 NN denotes amounts
T5477 728-735 JJ denotes minimal
T5476 723-727 IN denotes with
T5475 717-722 NN denotes cells
T5474 709-716 NN denotes control
T5473 704-708 NN denotes type
T5472 699-703 JJ denotes wild
T5471 695-698 CC denotes and
T5470 690-694 NN denotes BMDM
T5469 679-689 NN denotes A20myel-KO
T5468 667-678 VB denotes transfected
T5467 664-666 PRP denotes we
T5466 662-663 -COMMA- denotes ,
T5465 654-662 NN denotes receptor
T5464 648-653 NN denotes RIG-I
T5463 644-647 DT denotes the
T5462 634-643 VB denotes stimulate
T5461 631-633 TO denotes To
T5460 628-629 -RRB- denotes ]
T5459 626-628 CD denotes 48
T5458 625-626 -LRB- denotes [
T5457 620-624 NN denotes mice
T5456 611-619 NN denotes knockout
T5455 607-610 NN denotes A20
T5454 598-606 JJ denotes specific
T5453 593-597 NN denotes cell
T5452 585-592 JJ denotes myeloid
T5451 576-584 VB denotes generate
T5450 573-575 TO denotes to
T5449 570-572 PRP denotes us
T5448 562-569 VB denotes allowed
T5447 558-561 CC denotes and
T5446 552-557 NN denotes cells
T5445 544-551 JJ denotes myeloid
T5847 2743-2754 NN denotes macrophages
T5846 2735-2742 JJ denotes primary
T5845 2732-2734 IN denotes in
T5844 2721-2731 NN denotes activation
T5843 2716-2720 NN denotes IRF3
T5842 2712-2715 CC denotes and
T5841 2706-2711 NN denotes NF-κB
T5840 2692-2705 JJ denotes RIG-I-induced
T5839 2689-2691 IN denotes of
T5838 2678-2688 NN denotes regulation
T5837 2669-2677 JJ denotes negative
T5836 2665-2668 DT denotes the
T5835 2662-2664 IN denotes in
T5834 2657-2661 NN denotes role
T5833 2647-2656 JJ denotes important
T5832 2644-2646 DT denotes an
T5831 2638-2643 VB denotes plays
T5830 2634-2637 NN denotes A20
T5829 2629-2633 IN denotes that
T5828 2617-2628 VB denotes demonstrate
T5827 2609-2616 NN denotes results
T5826 2603-2608 DT denotes these
T5825 2601-2602 -COMMA- denotes ,
T5824 2593-2601 RB denotes Together
T5823 2590-2591 -RRB- denotes )
T5822 2585-2590 VB denotes shown
T5821 2581-2584 RB denotes not
T5820 2576-2580 NN denotes data
T5819 2575-2576 -LRB- denotes (
T5818 2563-2574 NN denotes macrophages
T5817 2552-2562 JJ denotes peritoneal
T5816 2546-2551 VB denotes using
T5815 2537-2545 VB denotes obtained
T5814 2532-2536 VB denotes were
T5813 2524-2531 NN denotes results
T5812 2516-2523 JJ denotes Similar
T5811 2513-2514 -RRB- denotes )
T5810 2511-2513 NN denotes 1D
T5809 2504-2510 NN denotes figure
T5808 2503-2504 -LRB- denotes (
T5807 2498-2502 NN denotes IFNβ
T5806 2494-2497 CC denotes and
T5805 2490-2493 NN denotes TNF
T5804 2488-2489 -COMMA- denotes ,
T5803 2484-2488 NN denotes IL-6
T5802 2481-2483 IN denotes of
T5801 2473-2480 NN denotes amounts
T5800 2463-2472 VB denotes increased
T5799 2454-2462 VB denotes secreted
T5798 2449-2453 NN denotes BMDM
T5797 2438-2448 NN denotes A20myel-KO
T5796 2436-2437 -COMMA- denotes ,
T5795 2431-2436 IN denotes above
T5794 2421-2430 VB denotes described
T5793 2418-2420 IN denotes as
T5792 2413-2417 NN denotes IRF3
T5791 2409-2412 CC denotes and
T5790 2403-2408 NN denotes NF-κB
T5789 2400-2402 IN denotes of
T5788 2389-2399 NN denotes activation
T5787 2380-2388 VB denotes enhanced
T5786 2376-2379 DT denotes the
T5785 2371-2375 IN denotes with
T5784 2366-2370 NN denotes line
T5783 2363-2365 IN denotes In
T5782 2357-2361 NN denotes IFNβ
T5781 2354-2356 IN denotes of
T5780 2343-2353 NN denotes expression
T5779 2339-2342 DT denotes the
T5778 2331-2338 VB denotes control
T5777 2326-2330 NN denotes IRF3
T5776 2322-2325 CC denotes and
T5775 2316-2321 NN denotes NF-κB
T5774 2312-2315 CC denotes and
T5773 2310-2311 -COMMA- denotes ,
T5772 2307-2310 NN denotes TNF
T5771 2303-2306 CC denotes and
T5770 2298-2302 NN denotes IL-6
T5769 2295-2297 IN denotes of
T5768 2284-2294 NN denotes expression
T5767 2280-2283 DT denotes the
T5766 2271-2279 VB denotes controls
T5765 2265-2270 NN denotes NF-κB
T5764 2262-2263 -RRB- denotes )
T5763 2260-2262 NN denotes 1C
T5762 2253-2259 NN denotes figure
T5761 2252-2253 -LRB- denotes (
T5760 2246-2251 NN denotes cells
T5759 2241-2245 NN denotes type
T5758 2236-2240 JJ denotes wild
T5757 2233-2235 TO denotes to
T5756 2224-2232 VB denotes compared
T5755 2219-2223 NN denotes BMDM
T5754 2209-2218 JJ denotes deficient
T5753 2205-2208 NN denotes A20
T5752 2202-2204 IN denotes in
T5751 2196-2201 NN denotes point
T5750 2191-2195 NN denotes time
T5749 2183-2190 JJ denotes earlier
T5748 2180-2182 DT denotes an
T5747 2177-2179 IN denotes at
T5746 2169-2176 NN denotes maximum
T5745 2165-2168 PRP-DOLLAR- denotes its
T5744 2157-2164 VB denotes reached
T5743 2143-2156 NN denotes translocation
T5742 2135-2142 JJ denotes nuclear
T5741 2130-2134 NN denotes IRF3
T5740 2128-2129 -COMMA- denotes ,
T5739 2125-2128 NN denotes p65
T5738 2122-2124 TO denotes to
T5737 2114-2121 JJ denotes Similar
T5736 2111-2112 -RRB- denotes )
T5735 2109-2111 NN denotes 1B
T5734 2102-2108 NN denotes figure
T5733 2101-2102 -LRB- denotes (
T5732 2096-2100 NN denotes BMDM
T5731 2091-2095 NN denotes type
T5730 2086-2090 JJ denotes wild
T5729 2083-2085 TO denotes to
T5728 2074-2082 VB denotes compared
T5727 2069-2073 NN denotes BMDM
T5726 2058-2068 NN denotes A20myel-KO
T5725 2055-2057 IN denotes in
T5724 2048-2054 NN denotes points
T5723 2043-2047 NN denotes time
T5722 2035-2042 JJ denotes earlier
T5721 2032-2034 IN denotes at
T5720 2023-2031 VB denotes detected
T5719 2019-2022 VB denotes was
T5718 2003-2018 NN denotes phosphorylation
T5717 1998-2002 NN denotes IRF3
T5716 1990-1997 JJ denotes maximum
T5715 1988-1989 -COMMA- denotes ,
T5714 1982-1988 NN denotes Ser396
T5713 1967-1981 VB denotes phosphorylated
T5712 1959-1966 IN denotes against
T5711 1950-1958 VB denotes directed
T5710 1941-1949 NN denotes antibody
T5709 1938-1940 DT denotes an
T5708 1933-1937 IN denotes with
T5707 1918-1932 NN denotes immunoblotting
T5706 1912-1917 VB denotes Using
T5705 1909-1910 -RRB- denotes ]
T5704 1907-1909 CD denotes 59
T5703 1906-1907 -LRB- denotes [
T5702 1898-1905 NN denotes nucleus
T5701 1894-1897 DT denotes the
T5700 1891-1893 TO denotes to
T5699 1877-1890 NN denotes translocation
T5698 1866-1876 JJ denotes subsequent
T5697 1862-1865 CC denotes and
T5696 1849-1861 NN denotes dimerization
T5695 1845-1848 PRP-DOLLAR- denotes its
T5694 1842-1844 TO denotes to
T5693 1834-1841 VB denotes leading
T5692 1832-1833 -COMMA- denotes ,
T5691 1831-1832 -RRB- denotes ]
T5690 1829-1831 CD denotes 58
T5689 1828-1829 -LRB- denotes [
T5688 1823-1827 NN denotes IKKε
T5687 1819-1822 CC denotes and
T5686 1814-1818 NN denotes TBK1
T5685 1806-1813 NN denotes kinases
T5684 1797-1805 JJ denotes IKK-like
T5683 1793-1796 DT denotes the
T5682 1790-1792 IN denotes by
T5681 1781-1789 NN denotes residues
T5680 1774-1780 NN denotes serine
T5679 1765-1773 JJ denotes terminal
T5678 1756-1764 NN denotes carboxyl
T5677 1753-1755 IN denotes of
T5676 1746-1752 NN denotes series
T5675 1744-1745 DT denotes a
T5674 1741-1743 IN denotes of
T5673 1725-1740 NN denotes phosphorylation
T5672 1720-1724 IN denotes upon
T5671 1710-1719 VB denotes activated
T5670 1707-1709 VB denotes be
T5669 1704-1706 TO denotes to
T5668 1698-1703 VB denotes known
T5667 1695-1697 VB denotes is
T5666 1690-1694 NN denotes IRF3
T5665 1687-1688 -RRB- denotes )
T5664 1685-1687 NN denotes 1C
T5663 1678-1684 NN denotes figure
T5662 1677-1678 -LRB- denotes (
T5661 1671-1676 NN denotes cells
T5444 541-543 IN denotes in
T5443 532-540 NN denotes deletion
T5442 523-531 JJ denotes specific
T5441 520-522 TO denotes to
T5440 514-519 VB denotes leads
T5439 505-513 NN denotes promoter
T5438 503-504 NN denotes M
T5437 494-502 NN denotes lysozyme
T5436 490-493 DT denotes the
T5435 487-489 IN denotes of
T5434 479-486 NN denotes control
T5433 473-478 IN denotes under
T5432 461-472 NN denotes recombinase
T5431 457-460 NNP denotes Cre
T5430 446-456 VB denotes expressing
T5429 441-445 NN denotes mice
T5428 430-440 JJ denotes transgenic
T5427 425-429 IN denotes with
T5426 420-424 NN denotes mice
T5425 414-419 DT denotes these
T5424 405-413 VB denotes Crossing
T5423 402-403 -RRB- denotes ]
T5422 400-402 CD denotes 56
T5421 399-400 -LRB- denotes [
T5420 393-398 NN denotes sites
T5419 388-392 NN denotes loxP
T5418 384-387 CD denotes two
T5417 381-383 IN denotes by
T5416 373-380 VB denotes flanked
T5415 368-372 VB denotes were
T5414 366-367 CD denotes V
T5413 361-365 NN denotes exon
T5412 357-360 CC denotes and
T5411 354-356 CD denotes IV
T5410 349-353 NN denotes exon
T5409 343-348 WDT denotes which
T5408 340-342 IN denotes in
T5407 333-339 NN denotes allele
T5406 329-332 NN denotes A20
T5405 317-328 JJ denotes conditional
T5404 315-316 DT denotes a
T5403 306-314 VB denotes carrying
T5402 301-305 NN denotes mice
T5401 291-300 VB denotes generated
T5400 288-290 PRP denotes we
T5399 286-287 -COMMA- denotes ,
T5398 285-286 -RRB- denotes ]
T5397 283-285 CD denotes 37
T5396 282-283 -LRB- denotes [
T5395 269-281 NN denotes inflammation
T5394 257-268 JJ denotes multi-organ
T5393 250-256 JJ denotes severe
T5392 247-249 IN denotes of
T5391 240-246 NN denotes result
T5390 238-239 DT denotes a
T5389 235-237 IN denotes as
T5388 223-234 RB denotes prematurely
T5387 219-222 VB denotes die
T5386 214-218 NN denotes mice
T5385 205-213 NN denotes knockout
T5384 200-204 JJ denotes full
T5383 196-199 NN denotes A20
T5382 190-195 IN denotes Since
T5381 177-188 NN denotes macrophages
T5380 169-176 JJ denotes primary
T5379 159-168 JJ denotes deficient
T5378 155-158 NN denotes A20
T5377 152-154 IN denotes in
T5376 140-151 NN denotes experiments
T5375 132-139 JJ denotes further
T5374 122-131 VB denotes performed
T5373 119-121 PRP denotes we
T5372 117-118 -COMMA- denotes ,
T5371 110-117 NN denotes context
T5370 101-109 JJ denotes relevant
T5369 87-100 JJ denotes immunological
T5368 82-86 RB denotes more
T5367 80-81 DT denotes a
T5366 77-79 IN denotes in
T5365 67-76 NN denotes signaling
T5364 53-66 JJ denotes RIG-I-induced
T5363 50-52 IN denotes on
T5362 46-49 NN denotes A20
T5361 36-45 VB denotes expressed
T5360 23-35 RB denotes endogenously
T5359 20-22 IN denotes of
T5358 13-19 NN denotes effect
T5357 9-12 DT denotes the
T5356 3-8 VB denotes study
T5355 0-2 TO denotes To
R3608 T5356 T5355 arg1Of study,To
R3609 T5358 T5356 arg2Of effect,study
R3610 T5358 T5357 arg1Of effect,the
R3611 T5358 T5359 arg1Of effect,of
R3612 T5358 T5363 arg1Of effect,on
R3613 T5358 T5366 arg1Of effect,in
R3614 T5361 T5360 arg1Of expressed,endogenously
R3615 T5362 T5359 arg2Of A20,of
R3616 T5362 T5361 arg1Of A20,expressed
R3617 T5365 T5363 arg2Of signaling,on
R3618 T5365 T5364 arg1Of signaling,RIG-I-induced
R3619 T5369 T5368 arg1Of immunological,more
R3620 T5371 T5366 arg2Of context,in
R3621 T5371 T5367 arg1Of context,a
R3622 T5371 T5369 arg1Of context,immunological
R3623 T5371 T5370 arg1Of context,relevant
R3624 T5373 T5356 arg1Of we,study
R3625 T5373 T5374 arg1Of we,performed
R3626 T5374 T5355 modOf performed,To
R3627 T5374 T5372 arg1Of performed,","
R3628 T5376 T5374 arg2Of experiments,performed
R3629 T5376 T5375 arg1Of experiments,further
R3630 T5376 T5377 arg1Of experiments,in
R3631 T5381 T5377 arg2Of macrophages,in
R3632 T5381 T5378 arg1Of macrophages,A20
R3633 T5381 T5379 arg1Of macrophages,deficient
R3634 T5381 T5380 arg1Of macrophages,primary
R3635 T5386 T5383 arg1Of mice,A20
R3636 T5386 T5384 arg1Of mice,full
R3637 T5386 T5385 arg1Of mice,knockout
R3638 T5386 T5387 arg1Of mice,die
R3639 T5387 T5382 arg2Of die,Since
R3640 T5387 T5388 arg1Of die,prematurely
R3641 T5387 T5389 arg1Of die,as
R3642 T5391 T5389 arg2Of result,as
R3643 T5391 T5390 arg1Of result,a
R3644 T5391 T5392 arg1Of result,of
R3645 T5395 T5392 arg2Of inflammation,of
R3646 T5395 T5393 arg1Of inflammation,severe
R3647 T5395 T5394 arg1Of inflammation,multi-organ
R3648 T5395 T5396 arg1Of inflammation,[
R3649 T5397 T5396 arg2Of 37,[
R3650 T5398 T5396 arg3Of ],[
R3651 T5400 T5401 arg1Of we,generated
R3652 T5401 T5382 arg1Of generated,Since
R3653 T5401 T5399 arg1Of generated,","
R3654 T5402 T5401 arg2Of mice,generated
R3655 T5402 T5403 arg1Of mice,carrying
R3656 T5407 T5403 arg2Of allele,carrying
R3657 T5407 T5404 arg1Of allele,a
R3658 T5407 T5405 arg1Of allele,conditional
R3659 T5407 T5406 arg1Of allele,A20
R3660 T5407 T5408 arg2Of allele,in
R3661 T5407 T5409 arg1Of allele,which
R3662 T5410 T5411 arg1Of exon,IV
R3663 T5410 T5412 arg1Of exon,and
R3664 T5412 T5415 arg1Of and,were
R3665 T5412 T5416 arg2Of and,flanked
R3666 T5413 T5412 arg2Of exon,and
R3667 T5413 T5414 arg1Of exon,V
R3668 T5416 T5408 arg1Of flanked,in
R3669 T5416 T5415 arg2Of flanked,were
R3670 T5416 T5417 arg1Of flanked,by
R3671 T5420 T5417 arg2Of sites,by
R3672 T5420 T5418 arg1Of sites,two
R3673 T5420 T5419 arg1Of sites,loxP
R3674 T5420 T5421 arg1Of sites,[
R3675 T5422 T5421 arg2Of 56,[
R3676 T5423 T5421 arg3Of ],[
R3678 T5424 T5448 arg1Of Crossing,allowed
R3679 T5426 T5424 arg2Of mice,Crossing
R3680 T5426 T5425 arg1Of mice,these
R3681 T5426 T5427 arg1Of mice,with
R3682 T5429 T5427 arg2Of mice,with
R3683 T5429 T5428 arg1Of mice,transgenic
R3684 T5429 T5430 arg1Of mice,expressing
R3685 T5430 T5433 arg1Of expressing,under
R3686 T5432 T5430 arg2Of recombinase,expressing
R3687 T5432 T5431 arg1Of recombinase,Cre
R3688 T5434 T5433 arg2Of control,under
R3689 T5434 T5435 arg1Of control,of
R3690 T5439 T5435 arg2Of promoter,of
R3691 T5439 T5436 arg1Of promoter,the
R3692 T5439 T5437 arg1Of promoter,lysozyme
R3693 T5439 T5438 arg1Of promoter,M
R3694 T5440 T5441 arg1Of leads,to
R3695 T5440 T5444 arg1Of leads,in
R3696 T5440 T5447 arg1Of leads,and
R3697 T5443 T5441 arg2Of deletion,to
R3698 T5443 T5442 arg1Of deletion,specific
R3699 T5446 T5444 arg2Of cells,in
R3700 T5446 T5445 arg1Of cells,myeloid
R3701 T5448 T5447 arg2Of allowed,and
R3702 T5449 T5448 arg2Of us,allowed
R3703 T5449 T5451 arg1Of us,generate
R3704 T5451 T5448 arg3Of generate,allowed
R3705 T5451 T5450 arg1Of generate,to
R3706 T5457 T5451 arg2Of mice,generate
R3707 T5457 T5452 arg1Of mice,myeloid
R3708 T5457 T5453 arg1Of mice,cell
R3709 T5457 T5454 arg1Of mice,specific
R3710 T5457 T5455 arg1Of mice,A20
R3711 T5457 T5456 arg1Of mice,knockout
R3712 T5457 T5458 arg1Of mice,[
R3713 T5459 T5458 arg2Of 48,[
R3714 T5460 T5458 arg3Of ],[
R3715 T5462 T5461 arg1Of stimulate,To
R3716 T5465 T5462 arg2Of receptor,stimulate
R3717 T5465 T5463 arg1Of receptor,the
R3718 T5465 T5464 arg1Of receptor,RIG-I
R3719 T5467 T5462 arg1Of we,stimulate
R3720 T5467 T5468 arg1Of we,transfected
R3721 T5468 T5461 modOf transfected,To
R3722 T5468 T5466 arg1Of transfected,","
R3723 T5470 T5469 arg1Of BMDM,A20myel-KO
R3724 T5470 T5471 arg1Of BMDM,and
R3725 T5471 T5468 arg2Of and,transfected
R3726 T5471 T5476 arg1Of and,with
R3727 T5475 T5471 arg2Of cells,and
R3728 T5475 T5472 arg1Of cells,wild
R3729 T5475 T5473 arg1Of cells,type
R3730 T5475 T5474 arg1Of cells,control
R3731 T5478 T5476 arg2Of amounts,with
R3732 T5478 T5477 arg1Of amounts,minimal
R3733 T5478 T5479 arg1Of amounts,of
R3734 T5484 T5483 arg2Of LMW,(
R3735 T5485 T5483 arg3Of ),(
R3736 T5486 T5479 arg2Of poly,of
R3737 T5486 T5480 arg1Of poly,low
R3738 T5486 T5481 arg1Of poly,molecular
R3739 T5486 T5482 arg1Of poly,weight
R3740 T5486 T5483 arg1Of poly,(
R3741 T5486 T5487 arg1Of poly,(
R3742 T5486 T5492 arg1Of poly,","
R3743 T5486 T5493 arg1Of poly,which
R3744 T5486 T5494 arg1Of poly,is
R3745 T5486 T5495 arg2Of poly,known
R3746 T5486 T5498 arg1Of poly,bind
R3747 T5486 T5500 arg1Of poly,activate
R3748 T5488 T5487 arg2Of I,(
R3749 T5488 T5489 arg1Of I,:
R3750 T5488 T5490 arg1Of I,C
R3751 T5491 T5487 arg3Of ),(
R3752 T5495 T5494 arg2Of known,is
R3753 T5498 T5499 arg1Of bind,and
R3754 T5499 T5495 arg3Of and,known
R3755 T5499 T5496 arg1Of and,to
R3756 T5499 T5497 arg1Of and,preferentially
R3757 T5499 T5505 arg1Of and,[
R3758 T5500 T5499 arg2Of activate,and
R3759 T5501 T5503 arg1Of RIG-I,than
R3760 T5503 T5498 arg2Of than,bind
R3761 T5503 T5500 arg2Of than,activate
R3762 T5503 T5502 arg1Of than,rather
R3763 T5504 T5503 arg2Of MDA5,than
R3764 T5506 T5505 arg2Of 57,[
R3765 T5507 T5505 arg3Of ],[
R3766 T5509 T5508 arg2Of note,Of
R3767 T5512 T5511 arg1Of concentration,this
R3768 T5512 T5513 arg1Of concentration,of
R3769 T5512 T5520 arg1Of concentration,was
R3770 T5512 T5521 arg1Of concentration,unable
R3771 T5512 T5523 arg1Of concentration,induce
R3772 T5514 T5513 arg2Of poly,of
R3773 T5514 T5515 arg1Of poly,(
R3774 T5516 T5515 arg2Of I,(
R3775 T5516 T5517 arg1Of I,:
R3776 T5516 T5518 arg1Of I,C
R3777 T5519 T5515 arg3Of ),(
R3778 T5520 T5508 arg1Of was,Of
R3779 T5520 T5510 arg1Of was,","
R3780 T5521 T5520 arg2Of unable,was
R3781 T5523 T5521 arg2Of induce,unable
R3782 T5523 T5522 arg1Of induce,to
R3783 T5526 T5524 arg1Of dependent,significant
R3784 T5526 T5525 arg1Of dependent,TLR3
R3785 T5527 T5528 arg1Of NF-κB,and
R3786 T5529 T5528 arg2Of IRF3,and
R3787 T5530 T5526 arg1Of activation,dependent
R3788 T5530 T5527 arg1Of activation,NF-κB
R3789 T5530 T5529 arg1Of activation,IRF3
R3790 T5530 T5531 arg1Of activation,or
R3791 T5531 T5523 arg2Of or,induce
R3792 T5533 T5531 arg2Of production,or
R3793 T5533 T5532 arg1Of production,cytokine
R3794 T5533 T5534 arg1Of production,(
R3795 T5535 T5534 arg2Of data,(
R3796 T5535 T5537 arg2Of data,shown
R3797 T5537 T5536 arg1Of shown,not
R3798 T5538 T5534 arg3Of ),(
R3799 T5540 T5539 arg2Of expected,As
R3800 T5544 T5543 arg2Of I,(
R3801 T5544 T5545 arg1Of I,:
R3802 T5544 T5546 arg1Of I,C
R3803 T5547 T5543 arg3Of ),(
R3804 T5548 T5542 arg1Of transfection,poly
R3805 T5548 T5543 arg1Of transfection,(
R3806 T5548 T5549 arg1Of transfection,induced
R3807 T5549 T5539 arg1Of induced,As
R3808 T5549 T5541 arg1Of induced,","
R3809 T5552 T5549 arg2Of expression,induced
R3810 T5552 T5550 arg1Of expression,the
R3811 T5552 T5551 arg1Of expression,rapid
R3812 T5552 T5553 arg1Of expression,of
R3813 T5554 T5553 arg2Of A20,of
R3814 T5554 T5555 arg1Of A20,in
R3815 T5554 T5561 arg1Of A20,in
R3816 T5555 T5559 arg1Of in,but
R3817 T5557 T5555 arg2Of type,in
R3818 T5557 T5556 arg1Of type,wild
R3819 T5559 T5558 arg1Of but,","
R3820 T5561 T5559 arg2Of in,but
R3821 T5561 T5560 arg1Of in,not
R3822 T5563 T5561 arg2Of BMDM,in
R3823 T5563 T5562 arg1Of BMDM,A20myel-KO
R3824 T5563 T5564 arg1Of BMDM,(
R3825 T5566 T5564 arg2Of 1B,(
R3826 T5566 T5565 arg1Of 1B,figure
R3827 T5566 T5567 arg1Of 1B,","
R3828 T5569 T5567 arg2Of panel,","
R3829 T5569 T5568 arg1Of panel,upper
R3830 T5570 T5564 arg3Of ),(
R3831 T5574 T5571 arg2Of points,At
R3832 T5574 T5572 arg1Of points,early
R3833 T5574 T5573 arg1Of points,time
R3834 T5579 T5576 arg1Of forms,slightly
R3835 T5579 T5577 arg1Of forms,slower
R3836 T5579 T5578 arg1Of forms,migrating
R3837 T5579 T5580 arg1Of forms,of
R3838 T5579 T5582 arg1Of forms,were
R3839 T5579 T5583 arg2Of forms,observed
R3840 T5581 T5580 arg2Of A20,of
R3841 T5583 T5571 arg1Of observed,At
R3842 T5583 T5575 arg1Of observed,","
R3843 T5583 T5582 arg2Of observed,were
R3844 T5583 T5584 arg1Of observed,","
R3845 T5583 T5585 modOf observed,indicating
R3846 T5587 T5588 arg1Of A20,undergoes
R3847 T5588 T5585 arg2Of undergoes,indicating
R3848 T5588 T5586 arg1Of undergoes,that
R3849 T5588 T5593 arg1Of undergoes,upon
R3850 T5591 T5590 arg1Of unknown,yet
R3851 T5592 T5588 arg2Of modification,undergoes
R3852 T5592 T5589 arg1Of modification,a
R3853 T5592 T5591 arg1Of modification,unknown
R3854 T5594 T5595 arg1Of poly,(
R3855 T5596 T5595 arg2Of I,(
R3856 T5596 T5597 arg1Of I,:
R3857 T5596 T5598 arg1Of I,C
R3858 T5599 T5595 arg3Of ),(
R3859 T5600 T5593 arg2Of transfection,upon
R3860 T5600 T5594 arg1Of transfection,poly
R3861 T5602 T5601 arg2Of to,Compared
R3862 T5605 T5602 arg2Of BMBM,to
R3863 T5605 T5603 arg1Of BMBM,wild
R3864 T5605 T5604 arg1Of BMBM,type
R3865 T5609 T5607 arg1Of cells,A20
R3866 T5609 T5608 arg1Of cells,deficient
R3867 T5609 T5610 arg1Of cells,showed
R3868 T5610 T5601 arg1Of showed,Compared
R3869 T5610 T5606 arg1Of showed,","
R3870 T5610 T5614 arg1Of showed,as
R3871 T5613 T5610 arg2Of activation,showed
R3872 T5613 T5611 arg2Of activation,enhanced
R3873 T5613 T5612 arg1Of activation,NF-κB
R3874 T5615 T5614 arg2Of indicated,as
R3875 T5618 T5617 arg2Of phosphorylation,increased
R3876 T5618 T5619 arg1Of phosphorylation,and
R3877 T5619 T5615 arg1Of and,indicated
R3878 T5619 T5616 arg2Of and,by
R3879 T5619 T5622 arg1Of and,of
R3880 T5621 T5619 arg2Of degradation,and
R3881 T5621 T5620 arg1Of degradation,sustained
R3882 T5623 T5622 arg2Of IκBα,of
R3883 T5623 T5624 arg1Of IκBα,(
R3884 T5626 T5624 arg2Of 1B,(
R3885 T5626 T5625 arg1Of 1B,figure
R3886 T5627 T5624 arg3Of ),(
R3887 T5631 T5630 arg1Of translocation,nuclear
R3888 T5631 T5632 arg1Of translocation,of
R3889 T5631 T5637 arg1Of translocation,was
R3890 T5631 T5638 arg2Of translocation,enhanced
R3891 T5636 T5632 arg2Of subunit,of
R3892 T5636 T5633 arg1Of subunit,the
R3893 T5636 T5634 arg1Of subunit,p65
R3894 T5636 T5635 arg1Of subunit,NF-κB
R3895 T5638 T5628 arg1Of enhanced,Furthermore
R3896 T5638 T5629 arg1Of enhanced,","
R3897 T5638 T5637 arg2Of enhanced,was
R3898 T5638 T5639 arg1Of enhanced,in
R3899 T5638 T5649 arg1Of enhanced,","
R3900 T5640 T5641 arg1Of poly,(
R3901 T5642 T5641 arg2Of I,(
R3902 T5642 T5643 arg1Of I,:
R3903 T5642 T5644 arg1Of I,C
R3904 T5645 T5641 arg3Of ),(
R3905 T5648 T5639 arg2Of BMDM,in
R3906 T5648 T5640 arg1Of BMDM,poly
R3907 T5648 T5646 arg2Of BMDM,transfected
R3908 T5648 T5647 arg1Of BMDM,A20myel-KO
R3909 T5650 T5638 arg3Of reaching,enhanced
R3910 T5650 T5653 arg1Of reaching,at
R3911 T5652 T5650 arg2Of maximum,reaching
R3912 T5652 T5651 arg1Of maximum,a
R3913 T5656 T5653 arg2Of points,at
R3914 T5656 T5654 arg1Of points,earlier
R3915 T5656 T5655 arg1Of points,time
R3916 T5656 T5657 arg2Of points,compared
R3917 T5657 T5658 arg1Of compared,to
R3918 T5661 T5658 arg2Of cells,to
R3919 T5661 T5659 arg1Of cells,wild
R3920 T5661 T5660 arg1Of cells,type
R3921 T5661 T5662 arg1Of cells,(
R3922 T5664 T5662 arg2Of 1C,(
R3923 T5664 T5663 arg1Of 1C,figure
R3924 T5665 T5662 arg3Of ),(
R3925 T5666 T5667 arg1Of IRF3,is
R3926 T5666 T5668 arg2Of IRF3,known
R3927 T5666 T5670 arg1Of IRF3,be
R3928 T5666 T5671 arg2Of IRF3,activated
R3929 T5668 T5667 arg2Of known,is
R3930 T5671 T5668 arg3Of activated,known
R3931 T5671 T5669 arg1Of activated,to
R3932 T5671 T5670 arg2Of activated,be
R3933 T5671 T5672 arg1Of activated,upon
R3934 T5671 T5692 arg1Of activated,","
R3935 T5671 T5693 modOf activated,leading
R3936 T5671 T5703 arg1Of activated,[
R3937 T5673 T5672 arg2Of phosphorylation,upon
R3938 T5673 T5674 arg1Of phosphorylation,of
R3939 T5676 T5674 arg2Of series,of
R3940 T5676 T5675 arg1Of series,a
R3941 T5676 T5677 arg1Of series,of
R3942 T5676 T5682 arg1Of series,by
R3943 T5681 T5677 arg2Of residues,of
R3944 T5681 T5678 arg1Of residues,carboxyl
R3945 T5681 T5679 arg1Of residues,terminal
R3946 T5681 T5680 arg1Of residues,serine
R3947 T5685 T5683 arg1Of kinases,the
R3948 T5685 T5684 arg1Of kinases,IKK-like
R3949 T5686 T5685 arg1Of TBK1,kinases
R3950 T5686 T5687 arg1Of TBK1,and
R3951 T5687 T5682 arg2Of and,by
R3952 T5688 T5687 arg2Of IKKε,and
R3953 T5688 T5689 arg1Of IKKε,[
R3954 T5690 T5689 arg2Of 58,[
R3955 T5691 T5689 arg3Of ],[
R3956 T5693 T5694 arg1Of leading,to
R3957 T5696 T5697 arg1Of dimerization,and
R3958 T5697 T5694 arg2Of and,to
R3959 T5697 T5695 arg1Of and,its
R3960 T5697 T5700 arg1Of and,to
R3961 T5699 T5697 arg2Of translocation,and
R3962 T5699 T5698 arg1Of translocation,subsequent
R3963 T5702 T5700 arg2Of nucleus,to
R3964 T5702 T5701 arg1Of nucleus,the
R3965 T5704 T5703 arg2Of 59,[
R3966 T5705 T5703 arg3Of ],[
R3967 T5707 T5706 arg2Of immunoblotting,Using
R3968 T5707 T5708 arg1Of immunoblotting,with
R3969 T5710 T5708 arg2Of antibody,with
R3970 T5710 T5709 arg1Of antibody,an
R3971 T5710 T5711 arg2Of antibody,directed
R3972 T5711 T5712 arg1Of directed,against
R3973 T5714 T5712 arg2Of Ser396,against
R3974 T5714 T5713 arg2Of Ser396,phosphorylated
R3975 T5718 T5706 arg1Of phosphorylation,Using
R3976 T5718 T5716 arg1Of phosphorylation,maximum
R3977 T5718 T5717 arg1Of phosphorylation,IRF3
R3978 T5718 T5719 arg1Of phosphorylation,was
R3979 T5718 T5720 arg2Of phosphorylation,detected
R3980 T5720 T5706 modOf detected,Using
R3981 T5720 T5715 arg1Of detected,","
R3982 T5720 T5719 arg2Of detected,was
R3983 T5720 T5721 arg1Of detected,at
R3984 T5720 T5728 arg1Of detected,compared
R3985 T5724 T5721 arg2Of points,at
R3986 T5724 T5722 arg1Of points,earlier
R3987 T5724 T5723 arg1Of points,time
R3988 T5724 T5725 arg1Of points,in
R3989 T5727 T5725 arg2Of BMDM,in
R3990 T5727 T5726 arg1Of BMDM,A20myel-KO
R3991 T5729 T5728 arg2Of to,compared
R3992 T5732 T5729 arg2Of BMDM,to
R3993 T5732 T5730 arg1Of BMDM,wild
R3994 T5732 T5731 arg1Of BMDM,type
R3995 T5732 T5733 arg1Of BMDM,(
R3996 T5735 T5733 arg2Of 1B,(
R3997 T5735 T5734 arg1Of 1B,figure
R3998 T5736 T5733 arg3Of ),(
R3999 T5737 T5738 arg1Of Similar,to
R4000 T5739 T5738 arg2Of p65,to
R4001 T5743 T5741 arg1Of translocation,IRF3
R4002 T5743 T5742 arg1Of translocation,nuclear
R4003 T5743 T5744 arg1Of translocation,reached
R4004 T5744 T5737 arg1Of reached,Similar
R4005 T5744 T5740 arg1Of reached,","
R4006 T5744 T5747 arg1Of reached,at
R4007 T5744 T5756 arg1Of reached,compared
R4008 T5746 T5744 arg2Of maximum,reached
R4009 T5746 T5745 arg1Of maximum,its
R4010 T5749 T5750 arg1Of earlier,time
R4011 T5751 T5747 arg2Of point,at
R4012 T5751 T5748 arg1Of point,an
R4013 T5751 T5749 arg1Of point,earlier
R4014 T5751 T5752 arg1Of point,in
R4015 T5755 T5752 arg2Of BMDM,in
R4016 T5755 T5753 arg1Of BMDM,A20
R4017 T5755 T5754 arg1Of BMDM,deficient
R4018 T5757 T5756 arg2Of to,compared
R4019 T5760 T5757 arg2Of cells,to
R4020 T5760 T5758 arg1Of cells,wild
R4021 T5760 T5759 arg1Of cells,type
R4022 T5760 T5761 arg1Of cells,(
R4023 T5763 T5761 arg2Of 1C,(
R4024 T5763 T5762 arg1Of 1C,figure
R4025 T5764 T5761 arg3Of ),(
R4026 T5765 T5766 arg1Of NF-κB,controls
R4027 T5766 T5774 arg1Of controls,and
R4028 T5768 T5766 arg2Of expression,controls
R4029 T5768 T5767 arg1Of expression,the
R4030 T5768 T5769 arg1Of expression,of
R4031 T5770 T5771 arg1Of IL-6,and
R4032 T5771 T5769 arg2Of and,of
R4033 T5772 T5771 arg2Of TNF,and
R4034 T5774 T5773 arg1Of and,","
R4035 T5775 T5776 arg1Of NF-κB,and
R4036 T5776 T5778 arg1Of and,control
R4037 T5777 T5776 arg2Of IRF3,and
R4038 T5778 T5774 arg2Of control,and
R4039 T5780 T5778 arg2Of expression,control
R4040 T5780 T5779 arg1Of expression,the
R4041 T5780 T5781 arg1Of expression,of
R4042 T5782 T5781 arg2Of IFNβ,of
R4043 T5784 T5783 arg2Of line,In
R4044 T5784 T5785 arg1Of line,with
R4045 T5788 T5785 arg2Of activation,with
R4046 T5788 T5786 arg1Of activation,the
R4047 T5788 T5787 arg2Of activation,enhanced
R4048 T5788 T5789 arg1Of activation,of
R4049 T5788 T5793 arg1Of activation,as
R4050 T5790 T5791 arg1Of NF-κB,and
R4051 T5791 T5789 arg2Of and,of
R4052 T5792 T5791 arg2Of IRF3,and
R4053 T5794 T5793 arg2Of described,as
R4054 T5794 T5795 arg1Of described,above
R4055 T5798 T5797 arg1Of BMDM,A20myel-KO
R4056 T5798 T5799 arg1Of BMDM,secreted
R4057 T5799 T5783 arg1Of secreted,In
R4058 T5799 T5796 arg1Of secreted,","
R4059 T5801 T5799 arg2Of amounts,secreted
R4060 T5801 T5800 arg2Of amounts,increased
R4061 T5801 T5802 arg1Of amounts,of
R4062 T5803 T5804 arg1Of IL-6,","
R4063 T5804 T5806 arg1Of ",",and
R4064 T5805 T5804 arg2Of TNF,","
R4065 T5806 T5802 arg2Of and,of
R4066 T5807 T5806 arg2Of IFNβ,and
R4067 T5807 T5808 arg1Of IFNβ,(
R4068 T5810 T5808 arg2Of 1D,(
R4069 T5810 T5809 arg1Of 1D,figure
R4070 T5811 T5808 arg3Of ),(
R4071 T5813 T5812 arg1Of results,Similar
R4072 T5813 T5814 arg1Of results,were
R4073 T5813 T5815 arg2Of results,obtained
R4074 T5815 T5814 arg2Of obtained,were
R4075 T5815 T5816 modOf obtained,using
R4076 T5818 T5816 arg2Of macrophages,using
R4077 T5818 T5817 arg1Of macrophages,peritoneal
R4078 T5818 T5819 arg1Of macrophages,(
R4079 T5820 T5819 arg2Of data,(
R4080 T5820 T5822 arg2Of data,shown
R4081 T5822 T5821 arg1Of shown,not
R4082 T5823 T5819 arg3Of ),(
R4083 T5827 T5826 arg1Of results,these
R4084 T5827 T5828 arg1Of results,demonstrate
R4085 T5828 T5824 arg1Of demonstrate,Together
R4086 T5828 T5825 arg1Of demonstrate,","
R4087 T5830 T5831 arg1Of A20,plays
R4088 T5831 T5828 arg2Of plays,demonstrate
R4089 T5831 T5829 arg1Of plays,that
R4090 T5831 T5835 arg1Of plays,in
R4091 T5834 T5831 arg2Of role,plays
R4092 T5834 T5832 arg1Of role,an
R4093 T5834 T5833 arg1Of role,important
R4094 T5838 T5835 arg2Of regulation,in
R4095 T5838 T5836 arg1Of regulation,the
R4096 T5838 T5837 arg1Of regulation,negative
R4097 T5838 T5839 arg1Of regulation,of
R4098 T5841 T5842 arg1Of NF-κB,and
R4099 T5843 T5842 arg2Of IRF3,and
R4100 T5844 T5839 arg2Of activation,of
R4101 T5844 T5840 arg1Of activation,RIG-I-induced
R4102 T5844 T5841 arg1Of activation,NF-κB
R4103 T5844 T5843 arg1Of activation,IRF3
R4104 T5844 T5845 arg1Of activation,in
R4105 T5847 T5845 arg2Of macrophages,in
R4106 T5847 T5846 arg1Of macrophages,primary
R3677 T5424 T5440 arg1Of Crossing,leads

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T4891 1690-1694 Antecedent denotes IRF3
T4890 1845-1848 Anaphor denotes its
R3329 T4890 T4891 boundBy its,IRF3

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T4944 2716-2720 Protein denotes IRF3
T4943 2692-2697 Protein denotes RIG-I
T4942 2498-2502 Protein denotes IFNβ
T4941 2490-2493 Protein denotes TNF
T4940 2484-2488 Protein denotes IL-6
T4939 2413-2417 Protein denotes IRF3
T4938 2357-2361 Protein denotes IFNβ
T4937 2326-2330 Protein denotes IRF3
T4936 2307-2310 Protein denotes TNF
T4935 2298-2302 Protein denotes IL-6
T4934 2130-2134 Protein denotes IRF3
T4933 2125-2128 Protein denotes p65
T4932 1998-2002 Protein denotes IRF3
T4931 1823-1827 Protein denotes IKKε
T4930 1814-1818 Protein denotes TBK1
T4929 1690-1694 Protein denotes IRF3
T4928 1534-1537 Protein denotes p65
T4927 1474-1478 Protein denotes IκBα
T4926 964-968 Protein denotes IRF3
T4925 939-943 Protein denotes TLR3
T4924 854-858 Protein denotes MDA5
T4923 836-841 Protein denotes RIG-I
T4922 648-653 Protein denotes RIG-I
T4921 53-58 Protein denotes RIG-I

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T6695 2490-2493 http://www.uniprot.org/uniprot/P01375 denotes TNF
T6694 2307-2310 http://www.uniprot.org/uniprot/P01375 denotes TNF
T6693 2484-2488 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T6692 2298-2302 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T6691 1814-1818 http://www.uniprot.org/uniprot/Q9UHD2 denotes TBK1
T6690 2125-2128 http://www.uniprot.org/uniprot/P21579 denotes p65
T6689 1534-1537 http://www.uniprot.org/uniprot/P21579 denotes p65
T6688 2125-2128 http://www.uniprot.org/uniprot/Q04206 denotes p65
T6687 1534-1537 http://www.uniprot.org/uniprot/Q04206 denotes p65
T6686 1474-1478 http://www.uniprot.org/uniprot/P25963 denotes IκBα
T6685 939-943 http://www.uniprot.org/uniprot/O15455 denotes TLR3
T6684 457-460 http://www.uniprot.org/uniprot/P06956 denotes Cre
T6671 2716-2720 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6670 2413-2417 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6669 2326-2330 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6668 2130-2134 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6667 1998-2002 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6666 1690-1694 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6665 964-968 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6656 2634-2637 http://www.uniprot.org/uniprot/P21580 denotes A20
T6655 2205-2208 http://www.uniprot.org/uniprot/P21580 denotes A20
T6654 1350-1353 http://www.uniprot.org/uniprot/P21580 denotes A20
T6653 1252-1255 http://www.uniprot.org/uniprot/P21580 denotes A20
T6652 1217-1220 http://www.uniprot.org/uniprot/P21580 denotes A20
T6651 1089-1092 http://www.uniprot.org/uniprot/P21580 denotes A20
T6650 607-610 http://www.uniprot.org/uniprot/P21580 denotes A20
T6649 329-332 http://www.uniprot.org/uniprot/P21580 denotes A20
T6648 196-199 http://www.uniprot.org/uniprot/P21580 denotes A20
T6647 155-158 http://www.uniprot.org/uniprot/P21580 denotes A20
T6646 46-49 http://www.uniprot.org/uniprot/P21580 denotes A20

UBERON-AE

Id Subject Object Predicate Lexical cue
T4723 263-268 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organ

GO-BP

Id Subject Object Predicate Lexical cue
T4949 2389-2408 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T4947 67-76 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T4962 2678-2688 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T4961 1814-1818 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T4960 1797-1800 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T4959 1459-1470 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T4958 2003-2018 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T4957 1725-1740 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T4956 1429-1444 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T4955 983-1002 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T4954 969-1002 http://purl.obolibrary.org/obo/GO_0001819 denotes activation or cytokine production
T4953 969-1002 http://purl.obolibrary.org/obo/GO_1903557 denotes activation or cytokine production
T4952 269-281 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

GO-MF

Id Subject Object Predicate Lexical cue
T4967 2484-2488 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T4966 2298-2302 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T4965 1941-1949 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T4964 1814-1818 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T4963 1797-1800 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK

GO-CC

Id Subject Object Predicate Lexical cue
T4976 1941-1949 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T4975 1941-1949 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T4974 1898-1905 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T4973 2246-2251 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4972 1671-1676 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4971 1364-1369 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4970 717-722 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4969 552-557 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T4749 2593-2755 Sentence denotes Together, these results demonstrate that A20 plays an important role in the negative regulation of RIG-I-induced NF-κB and IRF3 activation in primary macrophages.
T4748 2516-2592 Sentence denotes Similar results were obtained using peritoneal macrophages (data not shown).
T4747 2363-2515 Sentence denotes In line with the enhanced activation of NF-κB and IRF3 as described above, A20myel-KO BMDM secreted increased amounts of IL-6, TNF and IFNβ (figure 1D).
T4746 2265-2362 Sentence denotes NF-κB controls the expression of IL-6 and TNF, and NF-κB and IRF3 control the expression of IFNβ.
T4745 2114-2264 Sentence denotes Similar to p65, IRF3 nuclear translocation reached its maximum at an earlier time point in A20 deficient BMDM compared to wild type cells (figure 1C).
T4744 1912-2113 Sentence denotes Using immunoblotting with an antibody directed against phosphorylated Ser396, maximum IRF3 phosphorylation was detected at earlier time points in A20myel-KO BMDM compared to wild type BMDM (figure 1B).
T4743 1690-1911 Sentence denotes IRF3 is known to be activated upon phosphorylation of a series of carboxyl terminal serine residues by the IKK-like kinases TBK1 and IKKε [58], leading to its dimerization and subsequent translocation to the nucleus [59].
T4742 1492-1689 Sentence denotes Furthermore, nuclear translocation of the p65 NF-κB subunit was enhanced in poly(I:C) transfected A20myel-KO BMDM, reaching a maximum at earlier time points compared to wild type cells (figure 1C).
T4741 1322-1491 Sentence denotes Compared to wild type BMBM, A20 deficient cells showed enhanced NF-κB activation as indicated by increased phosphorylation and sustained degradation of IκBα (figure 1B).
T4740 1160-1321 Sentence denotes At early time points, slightly slower migrating forms of A20 were observed, indicating that A20 undergoes a yet unknown modification upon poly(I:C) transfection.
T4739 1021-1159 Sentence denotes As expected, poly(I:C) transfection induced the rapid expression of A20 in wild type, but not in A20myel-KO BMDM (figure 1B, upper panel).
T4738 865-1020 Sentence denotes Of note, this concentration of poly(I:C) was unable to induce significant TLR3 dependent NF-κB and IRF3 activation or cytokine production (data not shown).
T4737 631-864 Sentence denotes To stimulate the RIG-I receptor, we transfected A20myel-KO BMDM and wild type control cells with minimal amounts of low molecular weight (LMW) poly(I:C), which is known to preferentially bind and activate RIG-I rather than MDA5 [57].
T4736 405-630 Sentence denotes Crossing these mice with transgenic mice expressing Cre recombinase under control of the lysozyme M promoter leads to specific deletion in myeloid cells and allowed us to generate myeloid cell specific A20 knockout mice [48].
T4735 190-404 Sentence denotes Since A20 full knockout mice die prematurely as a result of severe multi-organ inflammation [37], we generated mice carrying a conditional A20 allele in which exon IV and exon V were flanked by two loxP sites [56].
T4734 0-189 Sentence denotes To study the effect of endogenously expressed A20 on RIG-I-induced signaling in a more immunological relevant context, we performed further experiments in A20 deficient primary macrophages.
T77 0-189 Sentence denotes To study the effect of endogenously expressed A20 on RIG-I-induced signaling in a more immunological relevant context, we performed further experiments in A20 deficient primary macrophages.
T78 190-404 Sentence denotes Since A20 full knockout mice die prematurely as a result of severe multi-organ inflammation [37], we generated mice carrying a conditional A20 allele in which exon IV and exon V were flanked by two loxP sites [56].
T79 405-630 Sentence denotes Crossing these mice with transgenic mice expressing Cre recombinase under control of the lysozyme M promoter leads to specific deletion in myeloid cells and allowed us to generate myeloid cell specific A20 knockout mice [48].
T80 631-864 Sentence denotes To stimulate the RIG-I receptor, we transfected A20myel-KO BMDM and wild type control cells with minimal amounts of low molecular weight (LMW) poly(I:C), which is known to preferentially bind and activate RIG-I rather than MDA5 [57].
T81 865-1020 Sentence denotes Of note, this concentration of poly(I:C) was unable to induce significant TLR3 dependent NF-κB and IRF3 activation or cytokine production (data not shown).
T82 1021-1159 Sentence denotes As expected, poly(I:C) transfection induced the rapid expression of A20 in wild type, but not in A20myel-KO BMDM (figure 1B, upper panel).
T83 1160-1321 Sentence denotes At early time points, slightly slower migrating forms of A20 were observed, indicating that A20 undergoes a yet unknown modification upon poly(I:C) transfection.
T84 1322-1491 Sentence denotes Compared to wild type BMBM, A20 deficient cells showed enhanced NF-κB activation as indicated by increased phosphorylation and sustained degradation of IκBα (figure 1B).
T85 1492-1689 Sentence denotes Furthermore, nuclear translocation of the p65 NF-κB subunit was enhanced in poly(I:C) transfected A20myel-KO BMDM, reaching a maximum at earlier time points compared to wild type cells (figure 1C).
T86 1690-1911 Sentence denotes IRF3 is known to be activated upon phosphorylation of a series of carboxyl terminal serine residues by the IKK-like kinases TBK1 and IKKε [58], leading to its dimerization and subsequent translocation to the nucleus [59].
T87 1912-2113 Sentence denotes Using immunoblotting with an antibody directed against phosphorylated Ser396, maximum IRF3 phosphorylation was detected at earlier time points in A20myel-KO BMDM compared to wild type BMDM (figure 1B).
T88 2114-2264 Sentence denotes Similar to p65, IRF3 nuclear translocation reached its maximum at an earlier time point in A20 deficient BMDM compared to wild type cells (figure 1C).
T89 2265-2362 Sentence denotes NF-κB controls the expression of IL-6 and TNF, and NF-κB and IRF3 control the expression of IFNβ.
T90 2363-2515 Sentence denotes In line with the enhanced activation of NF-κB and IRF3 as described above, A20myel-KO BMDM secreted increased amounts of IL-6, TNF and IFNβ (figure 1D).
T91 2516-2592 Sentence denotes Similar results were obtained using peritoneal macrophages (data not shown).
T92 2593-2755 Sentence denotes Together, these results demonstrate that A20 plays an important role in the negative regulation of RIG-I-induced NF-κB and IRF3 activation in primary macrophages.

simple1

Id Subject Object Predicate Lexical cue
T5082 2716-2720 Protein denotes IRF3
T5081 2692-2697 Protein denotes RIG-I
T5080 2498-2502 Protein denotes IFNβ
T5079 2490-2493 Protein denotes TNF
T5078 2484-2488 Protein denotes IL-6
T5077 2413-2417 Protein denotes IRF3
T5076 2357-2361 Protein denotes IFNβ
T5075 2326-2330 Protein denotes IRF3
T5074 2307-2310 Protein denotes TNF
T5073 2298-2302 Protein denotes IL-6
T5072 2130-2134 Protein denotes IRF3
T5071 2125-2128 Protein denotes p65
T5070 1998-2002 Protein denotes IRF3
T5069 1823-1827 Protein denotes IKKε
T5068 1814-1818 Protein denotes TBK1
T5067 1690-1694 Protein denotes IRF3
T5066 1534-1537 Protein denotes p65
T5065 1474-1478 Protein denotes IκBα
T5064 964-968 Protein denotes IRF3
T5063 939-943 Protein denotes TLR3
T5062 854-858 Protein denotes MDA5
T5061 836-841 Protein denotes RIG-I
T5060 648-653 Protein denotes RIG-I
T5059 53-58 Protein denotes RIG-I

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T7390 2678-2688 Regulation denotes regulation
T7389 2698-2705 Positive_regulation denotes induced
T7388 2657-2661 Regulation denotes role
T7387 2721-2731 Positive_regulation denotes activation
T7386 2389-2399 Positive_regulation denotes activation
T7385 2380-2388 Positive_regulation denotes enhanced
T7384 2454-2462 Localization denotes secreted
T7383 2343-2353 Gene_expression denotes expression
T7382 2271-2279 Regulation denotes controls
T7381 2284-2294 Gene_expression denotes expression
T7380 2331-2338 Regulation denotes control
T7379 2143-2156 Localization denotes translocation
T7378 2003-2018 Phosphorylation denotes phosphorylation
T7377 1710-1719 Positive_regulation denotes activated
T7376 1556-1564 Positive_regulation denotes enhanced
T7375 1513-1526 Localization denotes translocation
T7374 1459-1470 Protein_catabolism denotes degradation
T7373 1429-1444 Phosphorylation denotes phosphorylation
T7372 1419-1428 Positive_regulation denotes increased
T7371 920-926 Positive_regulation denotes induce
T7370 969-979 Positive_regulation denotes activation
T7369 827-835 Positive_regulation denotes activate
T7368 818-822 Binding denotes bind
T7341 2716-2720 Protein denotes IRF3
T7340 2692-2697 Protein denotes RIG-I
T7339 2498-2502 Protein denotes IFNβ
T7338 2490-2493 Protein denotes TNF
T7337 2484-2488 Protein denotes IL-6
T7336 2413-2417 Protein denotes IRF3
T7335 2357-2361 Protein denotes IFNβ
T7334 2326-2330 Protein denotes IRF3
T7333 2307-2310 Protein denotes TNF
T7332 2298-2302 Protein denotes IL-6
T7331 2130-2134 Protein denotes IRF3
T7330 2125-2128 Protein denotes p65
T7329 1998-2002 Protein denotes IRF3
T7328 1823-1827 Protein denotes IKKε
T7327 1814-1818 Protein denotes TBK1
T7326 1690-1694 Protein denotes IRF3
T7325 1534-1537 Protein denotes p65
T7324 1474-1478 Protein denotes IκBα
T7323 964-968 Protein denotes IRF3
T7322 939-943 Protein denotes TLR3
T7321 854-858 Protein denotes MDA5
T7320 836-841 Protein denotes RIG-I
T7319 648-653 Protein denotes RIG-I
T7318 53-58 Protein denotes RIG-I
R5284 T7337 T7384 themeOf IL-6,secreted
R5285 T7338 T7384 themeOf TNF,secreted
R5310 T7370 T7371 themeOf activation,induce
R5312 T7373 T7372 themeOf phosphorylation,increased
R5315 T7375 T7376 themeOf translocation,enhanced
R5317 T7390 T7388 themeOf regulation,role
R5318 T7381 T7382 themeOf expression,controls
R5319 T7381 T7382 themeOf expression,controls
R5320 T7383 T7380 themeOf expression,control
R5321 T7386 T7385 themeOf activation,enhanced
R5322 T7387 T7390 themeOf activation,regulation
R5323 T7387 T7389 themeOf activation,induced
R5264 T7320 T7368 themeOf RIG-I,bind
R5265 T7320 T7369 themeOf RIG-I,activate
R5266 T7321 T7369 themeOf MDA5,activate
R5268 T7323 T7370 themeOf IRF3,activation
R5269 T7324 T7372 themeOf IκBα,increased
R5270 T7324 T7373 themeOf IκBα,phosphorylation
R5271 T7324 T7374 themeOf IκBα,degradation
R5272 T7325 T7375 themeOf p65,translocation
R5274 T7326 T7377 themeOf IRF3,activated
R5276 T7329 T7378 themeOf IRF3,phosphorylation
R5277 T7331 T7379 themeOf IRF3,translocation
R5279 T7332 T7381 themeOf IL-6,expression
R5280 T7333 T7381 themeOf TNF,expression
R5281 T7335 T7383 themeOf IFNβ,expression
R5282 T7336 T7386 themeOf IRF3,activation
R5287 T7341 T7387 themeOf IRF3,activation

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T6748 2716-2720 Protein denotes IRF3
T6747 2692-2697 Protein denotes RIG-I
T6797 2698-2705 Positive_regulation denotes induced
T6796 2678-2688 Regulation denotes regulation
T6795 2721-2731 Positive_regulation denotes activation
T6794 2389-2399 Positive_regulation denotes activation
T6793 2380-2388 Positive_regulation denotes enhanced
T6792 2454-2462 Localization denotes secreted
T6791 2463-2472 Positive_regulation denotes increased
T6790 2343-2353 Gene_expression denotes expression
T6789 2271-2279 Regulation denotes controls
T6788 2284-2294 Gene_expression denotes expression
T6746 2498-2502 Protein denotes IFNβ
T6745 2490-2493 Protein denotes TNF
T6744 2484-2488 Protein denotes IL-6
T6743 2413-2417 Protein denotes IRF3
T6742 2357-2361 Protein denotes IFNβ
T6741 2326-2330 Protein denotes IRF3
T6740 2307-2310 Protein denotes TNF
T6739 2298-2302 Protein denotes IL-6
T6738 2130-2134 Protein denotes IRF3
T6737 2125-2128 Protein denotes p65
T6736 1998-2002 Protein denotes IRF3
T6735 1823-1827 Protein denotes IKKε
T6734 1814-1818 Protein denotes TBK1
T6733 1690-1694 Protein denotes IRF3
T6732 1534-1537 Protein denotes p65
T6731 1474-1478 Protein denotes IκBα
T6730 964-968 Protein denotes IRF3
T6729 939-943 Protein denotes TLR3
T6728 854-858 Protein denotes MDA5
T6727 836-841 Protein denotes RIG-I
T6726 648-653 Protein denotes RIG-I
T6725 53-58 Protein denotes RIG-I
T6787 2143-2156 Localization denotes translocation
T6786 2003-2018 Phosphorylation denotes phosphorylation
T6785 1513-1526 Localization denotes translocation
T6784 1556-1564 Positive_regulation denotes enhanced
T6783 1429-1444 Phosphorylation denotes phosphorylation
T6782 1419-1428 Positive_regulation denotes increased
T6781 1459-1470 Protein_catabolism denotes degradation
T6780 920-926 Positive_regulation denotes induce
T6779 969-979 Positive_regulation denotes activation
T6778 818-822 Binding denotes bind
T6777 827-835 Positive_regulation denotes activate
R4926 T6727 T6778 themeOf RIG-I,bind
R4927 T6727 T6777 themeOf RIG-I,activate
R4930 T6730 T6779 themeOf IRF3,activation
R4931 T6731 T6783 themeOf IκBα,phosphorylation
R4932 T6731 T6781 themeOf IκBα,degradation
R4933 T6732 T6785 themeOf p65,translocation
R4934 T6736 T6786 themeOf IRF3,phosphorylation
R4937 T6738 T6787 themeOf IRF3,translocation
R4938 T6739 T6788 themeOf IL-6,expression
R4939 T6740 T6788 themeOf TNF,expression
R4940 T6742 T6790 themeOf IFNβ,expression
R4942 T6743 T6794 themeOf IRF3,activation
R4943 T6744 T6792 themeOf IL-6,secreted
R4944 T6745 T6792 themeOf TNF,secreted
R4945 T6746 T6792 themeOf IFNβ,secreted
R4946 T6747 T6797 causeOf RIG-I,induced
R4948 T6748 T6795 themeOf IRF3,activation
R4949 T6779 T6780 themeOf activation,induce
R4950 T6783 T6782 themeOf phosphorylation,increased
R4951 T6785 T6784 themeOf translocation,enhanced
R4952 T6788 T6789 themeOf expression,controls
R4953 T6788 T6789 themeOf expression,controls
R4954 T6792 T6791 themeOf secreted,increased
R4955 T6792 T6791 themeOf secreted,increased
R4956 T6792 T6791 themeOf secreted,increased
R4957 T6794 T6793 themeOf activation,enhanced
R4958 T6795 T6796 themeOf activation,regulation
R4959 T6795 T6797 themeOf activation,induced

DLUT931

Id Subject Object Predicate Lexical cue
T6976 2698-2705 Positive_regulation denotes induced
T6975 2678-2688 Regulation denotes regulation
T6974 2721-2731 Positive_regulation denotes activation
T6973 2380-2388 Positive_regulation denotes enhanced
T6972 2463-2472 Positive_regulation denotes increased
T6971 2454-2462 Localization denotes secreted
T6970 2389-2399 Positive_regulation denotes activation
T6969 2271-2279 Regulation denotes controls
T6968 2343-2353 Gene_expression denotes expression
T6967 2284-2294 Gene_expression denotes expression
T6966 2157-2164 Positive_regulation denotes reached
T6965 2143-2156 Localization denotes translocation
T6964 2003-2018 Phosphorylation denotes phosphorylation
T6963 1710-1719 Positive_regulation denotes activated
T6962 1556-1564 Positive_regulation denotes enhanced
T6961 1513-1526 Localization denotes translocation
T6960 1419-1428 Positive_regulation denotes increased
T6959 1459-1470 Protein_catabolism denotes degradation
T6958 1429-1444 Phosphorylation denotes phosphorylation
T6957 920-926 Positive_regulation denotes induce
T6956 969-979 Positive_regulation denotes activation
T6922 2716-2720 Protein denotes IRF3
T6921 2692-2697 Protein denotes RIG-I
T6920 2498-2502 Protein denotes IFNβ
T6919 2490-2493 Protein denotes TNF
T6918 2484-2488 Protein denotes IL-6
T6917 2413-2417 Protein denotes IRF3
T6916 2357-2361 Protein denotes IFNβ
T6915 2326-2330 Protein denotes IRF3
T6914 2307-2310 Protein denotes TNF
T6913 2298-2302 Protein denotes IL-6
T6912 2130-2134 Protein denotes IRF3
T6911 2125-2128 Protein denotes p65
T6910 1998-2002 Protein denotes IRF3
T6909 1823-1827 Protein denotes IKKε
T6908 1814-1818 Protein denotes TBK1
T6907 1690-1694 Protein denotes IRF3
T6906 1534-1537 Protein denotes p65
T6905 1474-1478 Protein denotes IκBα
T6904 964-968 Protein denotes IRF3
T6903 939-943 Protein denotes TLR3
T6902 854-858 Protein denotes MDA5
T6901 836-841 Protein denotes RIG-I
T6900 648-653 Protein denotes RIG-I
T6899 53-58 Protein denotes RIG-I
T6955 827-835 Positive_regulation denotes activate
T6954 818-822 Binding denotes bind
T6953 634-643 Positive_regulation denotes stimulate
R5005 T6900 T6953 themeOf RIG-I,stimulate
R5008 T6901 T6954 themeOf RIG-I,bind
R5009 T6901 T6955 themeOf RIG-I,activate
R5010 T6902 T6954 themeOf MDA5,bind
R5012 T6902 T6955 themeOf MDA5,activate
R5015 T6904 T6956 themeOf IRF3,activation
R5017 T6905 T6958 themeOf IκBα,phosphorylation
R5018 T6956 T6957 themeOf activation,induce
R5019 T6905 T6959 themeOf IκBα,degradation
R5020 T6958 T6960 themeOf phosphorylation,increased
R5021 T6906 T6961 themeOf p65,translocation
R5022 T6961 T6962 themeOf translocation,enhanced
R5023 T6907 T6963 themeOf IRF3,activated
R5024 T6910 T6964 themeOf IRF3,phosphorylation
R5025 T6965 T6966 themeOf translocation,reached
R5026 T6967 T6969 themeOf expression,controls
R5027 T6967 T6969 themeOf expression,controls
R5028 T6912 T6965 themeOf IRF3,translocation
R5029 T6968 T6969 themeOf expression,controls
R5030 T6970 T6973 themeOf activation,enhanced
R5031 T6913 T6967 themeOf IL-6,expression
R5032 T6971 T6972 themeOf secreted,increased
R5033 T6971 T6972 themeOf secreted,increased
R5034 T6971 T6972 themeOf secreted,increased
R5035 T6974 T6975 themeOf activation,regulation
R5036 T6974 T6976 themeOf activation,induced
R5037 T6914 T6967 themeOf TNF,expression
R5038 T6976 T6974 themeOf induced,activation
R5039 T6916 T6968 themeOf IFNβ,expression
R5040 T6917 T6970 themeOf IRF3,activation
R5041 T6918 T6971 themeOf IL-6,secreted
R5043 T6918 T6972 themeOf IL-6,increased
R5044 T6919 T6971 themeOf TNF,secreted
R5048 T6919 T6972 themeOf TNF,increased
R5049 T6920 T6971 themeOf IFNβ,secreted
R5051 T6920 T6972 themeOf IFNβ,increased
R5054 T6921 T6976 causeOf RIG-I,induced
R5057 T6922 T6974 themeOf IRF3,activation

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue
T7570 2376-2417 Positive_regulation denotes the enhanced activation of NF-κB and IRF3
T7569 2376-2417 Positive_regulation denotes the enhanced activation of NF-κB and IRF3
T7568 420-513 Gene_expression denotes mice with transgenic mice expressing Cre recombinase under control of the lysozyme M promoter
T7564 2376-2417 Positive_regulation denotes the enhanced activation of NF-κB and IRF3
T7563 2376-2417 Positive_regulation denotes the enhanced activation of NF-κB and IRF3
T7562 964-979 Positive_regulation denotes IRF3 activation
T7559 2678-2697 Regulation denotes regulation of RIG-I
T7553 1449-1490 Protein_catabolism denotes sustained degradation of IκBα (figure 1B)
T7550 631-663 Positive_regulation denotes To stimulate the RIG-I receptor,
T7548 1990-2018 Phosphorylation denotes maximum IRF3 phosphorylation
T7547 2280-2310 Gene_expression denotes the expression of IL-6 and TNF
T7546 2280-2310 Gene_expression denotes the expression of IL-6 and TNF
T7527 1419-1444 Positive_regulation denotes increased phosphorylation
T7523 1377-1402 Positive_regulation denotes enhanced NF-κB activation
T7522 774-783 Entity denotes poly(I:C)
T7520 1753-1789 Entity denotes of carboxyl terminal serine residues
T7519 2233-2263 Entity denotes to wild type cells (figure 1C)
T7518 1998-2002 Protein denotes IRF3
T7515 2326-2330 Protein denotes IRF3
T7512 2413-2417 Protein denotes IRF3
T7510 964-968 Protein denotes IRF3
T7507 1350-1369 Entity denotes A20 deficient cells
T7505 2205-2208 Protein denotes A20
T7503 329-332 Protein denotes A20
T7500 927-959 Protein denotes significant TLR3 dependent NF-κB
T7497 1377-1402 Protein denotes enhanced NF-κB activation
T7496 1941-1949 Protein denotes antibody
T7495 430-445 Protein denotes transgenic mice
T7494 388-391 Protein denotes lox
T7493 315-403 Protein denotes a conditional A20 allele in which exon IV and exon V were flanked by two loxP sites [56]
T7491 2552-2591 Entity denotes peritoneal macrophages (data not shown)
T7488 2316-2321 Protein denotes NF-κB
T7484 155-188 Entity denotes A20 deficient primary macrophages
T7483 2307-2310 Protein denotes TNF
T7482 1298-1307 Entity denotes poly(I:C)
T7481 361-367 Entity denotes exon V
T7479 2130-2134 Protein denotes IRF3
T7478 494-502 Protein denotes lysozyme
T7477 155-158 Protein denotes A20
T7474 1774-1780 Entity denotes serine
T7472 1793-1818 Protein denotes the IKK-like kinases TBK1
T7471 2490-2493 Protein denotes TNF
T7469 1894-1905 Entity denotes the nucleus
T7467 2706-2711 Protein denotes NF-κB
T7466 1690-1694 Protein denotes IRF3
T7464 2735-2754 Entity denotes primary macrophages
T7462 854-863 Protein denotes MDA5 [57]
T7461 1471-1490 Protein denotes of IκBα (figure 1B)
T7459 1967-1988 Entity denotes phosphorylated Ser396
T7458 420-513 Protein denotes mice with transgenic mice expressing Cre recombinase under control of the lysozyme M promoter
T7457 544-557 Entity denotes myeloid cells
T7456 2498-2514 Protein denotes IFNβ (figure 1D)
T7455 836-841 Protein denotes RIG-I
T7454 1823-1832 Protein denotes IKKε [58]
T7453 50-58 Protein denotes on RIG-I
T7449 939-943 Protein denotes TLR3
T7448 457-460 Protein denotes Cre
T7447 1350-1353 Protein denotes A20
T7446 1568-1600 Entity denotes poly(I:C) transfected A20myel-KO
T7443 1217-1220 Protein denotes A20
T7442 2125-2129 Protein denotes p65,
T7440 1534-1537 Protein denotes p65
T7438 2634-2637 Protein denotes A20
T7433 2298-2302 Protein denotes IL-6
T7430 1658-1688 Entity denotes to wild type cells (figure 1C)
T7429 1793-1818 Protein denotes the IKK-like kinases TBK1
T7426 2354-2361 Protein denotes of IFNβ
T7424 457-472 Protein denotes Cre recombinase
T7423 585-629 Protein denotes myeloid cell specific A20 knockout mice [48]
T7422 1845-1861 Entity denotes its dimerization
T7421 893-905 Entity denotes of poly(I:C)
T7419 607-610 Protein denotes A20
T7418 2689-2697 Protein denotes of RIG-I
T7417 1086-1092 Protein denotes of A20
T7416 2403-2408 Protein denotes NF-κB
T7415 1252-1255 Protein denotes A20
T7414 2716-2720 Protein denotes IRF3
T7413 648-653 Protein denotes RIG-I
T7411 487-513 Entity denotes of the lysozyme M promoter
T7408 196-218 Protein denotes A20 full knockout mice
T7407 644-663 Protein denotes the RIG-I receptor,
T7406 585-606 Entity denotes myeloid cell specific
T7403 354-356 Protein denotes IV
T7401 2265-2270 Protein denotes NF-κB
T7400 196-199 Protein denotes A20
T7399 1527-1551 Protein denotes of the p65 NF-κB subunit
T7398 1034-1043 Entity denotes poly(I:C)
T7397 301-403 Protein denotes mice carrying a conditional A20 allele in which exon IV and exon V were flanked by two loxP sites [56]
T7395 2484-2488 Protein denotes IL-6
T7392 20-49 Protein denotes of endogenously expressed A20
T7391 381-403 Entity denotes by two loxP sites [56]
T7544 0-58 Regulation denotes To study the effect of endogenously expressed A20 on RIG-I
T7543 2265-2310 Regulation denotes NF-κB controls the expression of IL-6 and TNF
T7542 2265-2310 Regulation denotes NF-κB controls the expression of IL-6 and TNF
T7539 800-863 Positive_regulation denotes to preferentially bind and activate RIG-I rather than MDA5 [57]
T7538 20-49 Gene_expression denotes of endogenously expressed A20
T7536 2716-2731 Positive_regulation denotes IRF3 activation
T7535 2339-2361 Gene_expression denotes the expression of IFNβ
T7530 2316-2361 Regulation denotes NF-κB and IRF3 control the expression of IFNβ
T7529 2316-2361 Regulation denotes NF-κB and IRF3 control the expression of IFNβ
T7528 1065-1092 Gene_expression denotes the rapid expression of A20
R5324 T7401 T7542 causeOf NF-κB,NF-κB controls the expression of IL-6 and TNF
R5325 T7401 T7543 causeOf NF-κB,NF-κB controls the expression of IL-6 and TNF
R5326 T7407 T7550 themeOf "the RIG-I receptor,","To stimulate the RIG-I receptor,"
R5328 T7392 T7538 themeOf of endogenously expressed A20,of endogenously expressed A20
R5329 T7392 T7544 causeOf of endogenously expressed A20,To study the effect of endogenously expressed A20 on RIG-I
R5331 T7414 T7536 themeOf IRF3,IRF3 activation
R5332 T7416 T7564 themeOf NF-κB,the enhanced activation of NF-κB and IRF3
R5334 T7417 T7528 themeOf of A20,the rapid expression of A20
R5336 T7418 T7559 themeOf of RIG-I,regulation of RIG-I
R5337 T7510 T7562 themeOf IRF3,IRF3 activation
R5338 T7424 T7568 themeOf Cre recombinase,mice with transgenic mice expressing Cre recombinase under control of the lysozyme M promoter
R5340 T7512 T7563 themeOf IRF3,the enhanced activation of NF-κB and IRF3
R5342 T7515 T7529 causeOf IRF3,NF-κB and IRF3 control the expression of IFNβ
R5345 T7518 T7548 themeOf IRF3,maximum IRF3 phosphorylation
R5349 T7426 T7535 themeOf of IFNβ,the expression of IFNβ
R5352 T7535 T7529 themeOf the expression of IFNβ,NF-κB and IRF3 control the expression of IFNβ
R5353 T7535 T7530 themeOf the expression of IFNβ,NF-κB and IRF3 control the expression of IFNβ
R5354 T7433 T7546 themeOf IL-6,the expression of IL-6 and TNF
R5358 T7546 T7542 themeOf the expression of IL-6 and TNF,NF-κB controls the expression of IL-6 and TNF
R5359 T7547 T7543 themeOf the expression of IL-6 and TNF,NF-κB controls the expression of IL-6 and TNF
R5367 T7563 T7570 themeOf the enhanced activation of NF-κB and IRF3,the enhanced activation of NF-κB and IRF3
R5368 T7564 T7569 themeOf the enhanced activation of NF-κB and IRF3,the enhanced activation of NF-κB and IRF3
R5373 T7453 T7544 themeOf on RIG-I,To study the effect of endogenously expressed A20 on RIG-I
R5374 T7455 T7539 themeOf RIG-I,to preferentially bind and activate RIG-I rather than MDA5 [57]
R5375 T7461 T7553 themeOf of IκBα (figure 1B),sustained degradation of IκBα (figure 1B)
R5376 T7483 T7547 themeOf TNF,the expression of IL-6 and TNF
R5378 T7488 T7530 causeOf NF-κB,NF-κB and IRF3 control the expression of IFNβ
R5379 T7497 T7523 themeOf enhanced NF-κB activation,enhanced NF-κB activation

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T6602 2532-2536 VBD denotes were
T6601 2524-2531 NNS denotes results
T6600 2516-2523 JJ denotes Similar
T6599 2514-2515 . denotes .
T6598 2513-2514 -RRB- denotes )
T6597 2511-2513 VBN denotes 1D
T6596 2504-2510 NN denotes figure
T6595 2503-2504 -LRB- denotes (
T6594 2498-2502 NNP denotes IFNβ
T6593 2494-2497 CC denotes and
T6592 2490-2493 NNP denotes TNF
T6591 2488-2489 , denotes ,
T6590 2484-2488 NNP denotes IL-6
T6589 2481-2483 IN denotes of
T6588 2473-2480 NNS denotes amounts
T6587 2463-2472 VBN denotes increased
T6586 2454-2462 VBD denotes secreted
T6585 2449-2453 NNP denotes BMDM
T6584 2438-2448 JJ denotes A20myel-KO
T6583 2436-2437 , denotes ,
T6582 2431-2436 IN denotes above
T6581 2421-2430 VBN denotes described
T6580 2418-2420 IN denotes as
T6579 2413-2417 NNP denotes IRF3
T6578 2409-2412 CC denotes and
T6577 2403-2408 NNP denotes NF-κB
T6576 2400-2402 IN denotes of
T6575 2389-2399 NN denotes activation
T6574 2380-2388 JJ denotes enhanced
T6573 2376-2379 DT denotes the
T6572 2371-2375 IN denotes with
T6571 2366-2370 NN denotes line
T6570 2363-2365 IN denotes In
T6569 2361-2362 . denotes .
T6568 2357-2361 NNP denotes IFNβ
T6567 2354-2356 IN denotes of
T6566 2343-2353 NN denotes expression
T6565 2339-2342 DT denotes the
T6564 2331-2338 VBP denotes control
T6563 2326-2330 NNP denotes IRF3
T6562 2322-2325 CC denotes and
T6561 2316-2321 NNP denotes NF-κB
T6560 2312-2315 CC denotes and
T6559 2310-2311 , denotes ,
T6558 2307-2310 NNP denotes TNF
T6557 2303-2306 CC denotes and
T6556 2298-2302 NNP denotes IL-6
T6555 2295-2297 IN denotes of
T6554 2284-2294 NN denotes expression
T6553 2280-2283 DT denotes the
T6552 2271-2279 VBZ denotes controls
T6551 2265-2270 NN denotes NF-κB
T6550 2263-2264 . denotes .
T6549 2262-2263 -RRB- denotes )
T6369 1266-1267 DT denotes a
T6368 1256-1265 VBZ denotes undergoes
T6367 1252-1255 NNP denotes A20
T6366 1247-1251 IN denotes that
T6365 1236-1246 VBG denotes indicating
T6364 1234-1235 , denotes ,
T6363 1226-1234 VBN denotes observed
T6362 1221-1225 VBD denotes were
T6361 1217-1220 CD denotes A20
T6360 1214-1216 IN denotes of
T6359 1208-1213 NNS denotes forms
T6358 1198-1207 NN denotes migrating
T6357 1191-1197 JJR denotes slower
T6356 1182-1190 RB denotes slightly
T6355 1180-1181 , denotes ,
T6354 1174-1180 NNS denotes points
T6353 1169-1173 NN denotes time
T6352 1163-1168 JJ denotes early
T6351 1160-1162 IN denotes At
T6350 1158-1159 . denotes .
T6349 1157-1158 -RRB- denotes )
T6348 1152-1157 NN denotes panel
T6347 1146-1151 JJ denotes upper
T6346 1144-1145 , denotes ,
T6345 1142-1144 NN denotes 1B
T6344 1135-1141 NN denotes figure
T6343 1134-1135 -LRB- denotes (
T6342 1129-1133 NNP denotes BMDM
T6341 1118-1128 JJ denotes A20myel-KO
T6340 1115-1117 IN denotes in
T6339 1111-1114 RB denotes not
T6338 1107-1110 CC denotes but
T6337 1105-1106 , denotes ,
T6336 1101-1105 NN denotes type
T6335 1096-1100 JJ denotes wild
T6334 1093-1095 IN denotes in
T6333 1089-1092 NNP denotes A20
T6332 1086-1088 IN denotes of
T6331 1075-1085 NN denotes expression
T6330 1069-1074 JJ denotes rapid
T6329 1065-1068 DT denotes the
T6328 1057-1064 VBD denotes induced
T6327 1044-1056 NN denotes transfection
T6326 1042-1043 -RRB- denotes )
T6325 1041-1042 NNP denotes C
T6324 1040-1041 : denotes :
T6323 1039-1040 PRP denotes I
T6322 1038-1039 -LRB- denotes (
T6321 1034-1038 NN denotes poly
T6320 1032-1033 , denotes ,
T6319 1024-1032 VBN denotes expected
T6318 1021-1023 IN denotes As
T6317 1019-1020 . denotes .
T6316 1018-1019 -RRB- denotes )
T6315 1013-1018 VBN denotes shown
T6314 1009-1012 RB denotes not
T6313 1004-1008 NNS denotes data
T6312 1003-1004 -LRB- denotes (
T6311 992-1002 NN denotes production
T6310 983-991 NN denotes cytokine
T6309 980-982 CC denotes or
T6308 969-979 NN denotes activation
T6307 964-968 JJ denotes IRF3
T6306 960-963 CC denotes and
T6305 954-959 NN denotes NF-κB
T6304 944-953 JJ denotes dependent
T6303 939-943 CD denotes TLR3
T6302 927-938 JJ denotes significant
T6301 920-926 VB denotes induce
T6300 917-919 TO denotes to
T6299 910-916 JJ denotes unable
T6298 906-909 VBD denotes was
T6297 904-905 -RRB- denotes )
T6296 903-904 NNP denotes C
T6295 902-903 : denotes :
T6294 901-902 PRP denotes I
T6293 900-901 -LRB- denotes (
T6292 896-900 NN denotes poly
T6291 893-895 IN denotes of
T6290 879-892 NN denotes concentration
T6289 874-878 DT denotes this
T6288 872-873 , denotes ,
T6287 868-872 NN denotes note
T6286 865-867 IN denotes Of
T6285 863-864 . denotes .
T6284 862-863 NNP denotes ]
T6283 860-862 CD denotes 57
T6282 859-860 NNP denotes [
T6281 854-858 CD denotes MDA5
T6280 849-853 IN denotes than
T6279 842-848 RB denotes rather
T6278 836-841 NNP denotes RIG-I
T6277 827-835 VB denotes activate
T6276 823-826 CC denotes and
T6275 818-822 NN denotes bind
T6274 803-817 RB denotes preferentially
T6273 800-802 TO denotes to
T6272 794-799 VBN denotes known
T6271 791-793 VBZ denotes is
T6270 785-790 WDT denotes which
T6269 783-784 , denotes ,
T6268 782-783 -RRB- denotes )
T6267 781-782 NNP denotes C
T6266 780-781 : denotes :
T6265 779-780 PRP denotes I
T6264 778-779 -LRB- denotes (
T6263 774-778 NN denotes poly
T6262 772-773 -RRB- denotes )
T6261 769-772 NNP denotes LMW
T6260 768-769 -LRB- denotes (
T6259 761-767 NN denotes weight
T6258 751-760 JJ denotes molecular
T6257 747-750 JJ denotes low
T6256 744-746 IN denotes of
T6255 736-743 NNS denotes amounts
T6254 728-735 JJ denotes minimal
T6253 723-727 IN denotes with
T6252 717-722 NNS denotes cells
T6251 709-716 NN denotes control
T6250 704-708 NN denotes type
T6249 699-703 JJ denotes wild
T6248 695-698 CC denotes and
T6247 690-694 NNP denotes BMDM
T6246 679-689 JJ denotes A20myel-KO
T6245 667-678 VBD denotes transfected
T6244 664-666 PRP denotes we
T6243 662-663 , denotes ,
T6242 654-662 NN denotes receptor
T6241 648-653 NN denotes RIG-I
T6240 644-647 DT denotes the
T6239 634-643 VB denotes stimulate
T6238 631-633 TO denotes To
T6237 629-630 . denotes .
T6236 628-629 NNP denotes ]
T6235 626-628 CD denotes 48
T6234 625-626 VBP denotes [
T6233 620-624 NNS denotes mice
T6232 611-619 NN denotes knockout
T6231 607-610 NNP denotes A20
T6230 598-606 JJ denotes specific
T6229 593-597 NN denotes cell
T6228 585-592 JJ denotes myeloid
T6227 576-584 VB denotes generate
T6226 573-575 TO denotes to
T6225 570-572 PRP denotes us
T6224 562-569 VBD denotes allowed
T6223 558-561 CC denotes and
T6222 552-557 NNS denotes cells
T6221 544-551 JJ denotes myeloid
T6220 541-543 IN denotes in
T6219 532-540 NN denotes deletion
T6218 523-531 JJ denotes specific
T6217 520-522 TO denotes to
T6216 514-519 VBZ denotes leads
T6215 505-513 NN denotes promoter
T6214 503-504 NNP denotes M
T6213 494-502 NN denotes lysozyme
T6212 490-493 DT denotes the
T6211 487-489 IN denotes of
T6210 479-486 NN denotes control
T6209 473-478 IN denotes under
T6208 461-472 NN denotes recombinase
T6207 457-460 NNP denotes Cre
T6206 446-456 VBG denotes expressing
T6205 441-445 NNS denotes mice
T6204 430-440 JJ denotes transgenic
T6203 425-429 IN denotes with
T6202 420-424 NNS denotes mice
T6201 414-419 DT denotes these
T6200 405-413 VBG denotes Crossing
T6199 403-404 . denotes .
T6198 402-403 NNP denotes ]
T6197 400-402 CD denotes 56
T6196 399-400 NNP denotes [
T6195 393-398 NNS denotes sites
T6194 388-392 NNP denotes loxP
T6193 384-387 CD denotes two
T6192 381-383 IN denotes by
T6191 373-380 VBN denotes flanked
T6190 368-372 VBD denotes were
T6189 366-367 NNP denotes V
T6188 361-365 VB denotes exon
T6187 357-360 CC denotes and
T6186 354-356 NNP denotes IV
T6185 349-353 NN denotes exon
T6184 343-348 WDT denotes which
T6183 340-342 IN denotes in
T6182 333-339 NN denotes allele
T6181 329-332 NNP denotes A20
T6180 317-328 JJ denotes conditional
T6179 315-316 DT denotes a
T6178 306-314 VBG denotes carrying
T6177 301-305 NNS denotes mice
T6176 291-300 VBD denotes generated
T6175 288-290 PRP denotes we
T6174 286-287 , denotes ,
T6173 285-286 NNP denotes ]
T6172 283-285 CD denotes 37
T6171 282-283 NNP denotes [
T6170 269-281 NN denotes inflammation
T6169 257-268 JJ denotes multi-organ
T6168 250-256 JJ denotes severe
T6167 247-249 IN denotes of
T6166 240-246 NN denotes result
T6165 238-239 DT denotes a
T6164 235-237 IN denotes as
T6163 223-234 RB denotes prematurely
T6162 219-222 VBP denotes die
T6161 214-218 NNS denotes mice
T6160 205-213 NN denotes knockout
T6159 200-204 JJ denotes full
T6158 196-199 NNP denotes A20
T6157 190-195 IN denotes Since
T6156 188-189 . denotes .
T6155 177-188 NNS denotes macrophages
T6154 169-176 JJ denotes primary
T6526 2130-2134 JJ denotes IRF3
T6525 2128-2129 , denotes ,
T6524 2125-2128 VB denotes p65
T6523 2122-2124 TO denotes to
T6522 2114-2121 JJ denotes Similar
T6521 2112-2113 . denotes .
T6520 2111-2112 -RRB- denotes )
T6519 2109-2111 NN denotes 1B
T6518 2102-2108 NN denotes figure
T6517 2101-2102 -LRB- denotes (
T6516 2096-2100 NNP denotes BMDM
T6515 2091-2095 NN denotes type
T6514 2086-2090 JJ denotes wild
T6513 2083-2085 TO denotes to
T6512 2074-2082 VBN denotes compared
T6511 2069-2073 NNP denotes BMDM
T6510 2058-2068 JJ denotes A20myel-KO
T6509 2055-2057 IN denotes in
T6508 2048-2054 NNS denotes points
T6507 2043-2047 NN denotes time
T6506 2035-2042 JJR denotes earlier
T6505 2032-2034 IN denotes at
T6504 2023-2031 VBN denotes detected
T6503 2019-2022 VBD denotes was
T6502 2003-2018 NN denotes phosphorylation
T6501 1998-2002 CD denotes IRF3
T6500 1990-1997 NN denotes maximum
T6499 1988-1989 , denotes ,
T6498 1982-1988 NNP denotes Ser396
T6497 1967-1981 VBN denotes phosphorylated
T6496 1959-1966 IN denotes against
T6495 1950-1958 VBN denotes directed
T6494 1941-1949 NN denotes antibody
T6493 1938-1940 DT denotes an
T6492 1933-1937 IN denotes with
T6491 1918-1932 VBG denotes immunoblotting
T6490 1912-1917 VBG denotes Using
T6489 1910-1911 . denotes .
T6488 1909-1910 NNP denotes ]
T6487 1907-1909 CD denotes 59
T6486 1906-1907 NNP denotes [
T6485 1898-1905 NN denotes nucleus
T6484 1894-1897 DT denotes the
T6483 1891-1893 TO denotes to
T6482 1877-1890 NN denotes translocation
T6481 1866-1876 JJ denotes subsequent
T6480 1862-1865 CC denotes and
T6479 1849-1861 NN denotes dimerization
T6478 1845-1848 PRP$ denotes its
T6477 1842-1844 TO denotes to
T6476 1834-1841 VBG denotes leading
T6475 1832-1833 , denotes ,
T6474 1831-1832 NNP denotes ]
T6473 1829-1831 CD denotes 58
T6472 1828-1829 NNP denotes [
T6471 1823-1827 NNP denotes IKKε
T6470 1819-1822 CC denotes and
T6469 1814-1818 CD denotes TBK1
T6468 1806-1813 NNS denotes kinases
T6467 1797-1805 JJ denotes IKK-like
T6466 1793-1796 DT denotes the
T6465 1790-1792 IN denotes by
T6464 1781-1789 NNS denotes residues
T6463 1774-1780 NN denotes serine
T6462 1765-1773 NN denotes terminal
T6461 1756-1764 NN denotes carboxyl
T6460 1753-1755 IN denotes of
T6459 1746-1752 NN denotes series
T6458 1744-1745 DT denotes a
T6457 1741-1743 IN denotes of
T6456 1725-1740 NN denotes phosphorylation
T6455 1720-1724 IN denotes upon
T6454 1710-1719 VBN denotes activated
T6453 1707-1709 VB denotes be
T6452 1704-1706 TO denotes to
T6451 1698-1703 VBN denotes known
T6450 1695-1697 VBZ denotes is
T6449 1690-1694 CD denotes IRF3
T6448 1688-1689 . denotes .
T6447 1687-1688 -RRB- denotes )
T6446 1685-1687 NNP denotes 1C
T6445 1678-1684 NN denotes figure
T6444 1677-1678 -LRB- denotes (
T6443 1671-1676 NNS denotes cells
T6442 1666-1670 NN denotes type
T6441 1661-1665 JJ denotes wild
T6440 1658-1660 TO denotes to
T6439 1649-1657 VBN denotes compared
T6438 1642-1648 NNS denotes points
T6437 1637-1641 NN denotes time
T6436 1629-1636 JJR denotes earlier
T6435 1626-1628 IN denotes at
T6434 1618-1625 NN denotes maximum
T6433 1616-1617 DT denotes a
T6432 1607-1615 VBG denotes reaching
T6431 1605-1606 , denotes ,
T6430 1601-1605 NNP denotes BMDM
T6429 1590-1600 JJ denotes A20myel-KO
T6428 1578-1589 VBN denotes transfected
T6427 1576-1577 -RRB- denotes )
T6426 1575-1576 NNP denotes C
T6425 1574-1575 : denotes :
T6424 1573-1574 PRP denotes I
T6423 1572-1573 -LRB- denotes (
T6422 1568-1572 NN denotes poly
T6421 1565-1567 IN denotes in
T6420 1556-1564 VBN denotes enhanced
T6419 1552-1555 VBD denotes was
T6418 1544-1551 NN denotes subunit
T6417 1538-1543 NN denotes NF-κB
T6416 1534-1537 CD denotes p65
T6415 1530-1533 DT denotes the
T6414 1527-1529 IN denotes of
T6413 1513-1526 NN denotes translocation
T6412 1505-1512 JJ denotes nuclear
T6411 1503-1504 , denotes ,
T6410 1492-1503 RB denotes Furthermore
T6409 1490-1491 . denotes .
T6408 1489-1490 -RRB- denotes )
T6407 1487-1489 NN denotes 1B
T6406 1480-1486 NN denotes figure
T6405 1479-1480 -LRB- denotes (
T6404 1474-1478 NNP denotes IκBα
T6403 1471-1473 IN denotes of
T6402 1459-1470 NN denotes degradation
T6401 1449-1458 VBD denotes sustained
T6400 1445-1448 CC denotes and
T6399 1429-1444 NN denotes phosphorylation
T6398 1419-1428 VBN denotes increased
T6397 1416-1418 IN denotes by
T6396 1406-1415 VBN denotes indicated
T6395 1403-1405 IN denotes as
T6394 1392-1402 NN denotes activation
T6393 1386-1391 NN denotes NF-κB
T6392 1377-1385 JJ denotes enhanced
T6391 1370-1376 VBD denotes showed
T6390 1364-1369 NNS denotes cells
T6389 1354-1363 JJ denotes deficient
T6388 1350-1353 NNP denotes A20
T6387 1348-1349 , denotes ,
T6386 1344-1348 NNP denotes BMBM
T6385 1339-1343 NN denotes type
T6384 1334-1338 JJ denotes wild
T6383 1331-1333 TO denotes to
T6382 1322-1330 VBN denotes Compared
T6381 1320-1321 . denotes .
T6380 1308-1320 NN denotes transfection
T6379 1306-1307 -RRB- denotes )
T6378 1305-1306 NNP denotes C
T6377 1304-1305 : denotes :
T6376 1303-1304 PRP denotes I
T6375 1302-1303 -LRB- denotes (
T6374 1298-1302 NN denotes poly
T6373 1293-1297 IN denotes upon
T6372 1280-1292 NN denotes modification
T6371 1272-1279 JJ denotes unknown
T6370 1268-1271 RB denotes yet
T6152 155-158 NNP denotes A20
T6151 152-154 IN denotes in
T6150 140-151 NNS denotes experiments
T6149 132-139 JJ denotes further
T6148 122-131 VBD denotes performed
T6147 119-121 PRP denotes we
T6146 117-118 , denotes ,
T6145 110-117 NN denotes context
T6144 101-109 JJ denotes relevant
T6143 87-100 JJ denotes immunological
T6142 82-86 RBR denotes more
T6141 80-81 DT denotes a
T6140 77-79 IN denotes in
T6139 67-76 VBG denotes signaling
T6138 53-66 JJ denotes RIG-I-induced
T6137 50-52 IN denotes on
T6136 46-49 NNP denotes A20
T6135 36-45 VBN denotes expressed
T6134 23-35 RB denotes endogenously
T6133 20-22 IN denotes of
T6132 13-19 NN denotes effect
T6131 9-12 DT denotes the
T6130 3-8 VB denotes study
T6129 0-2 TO denotes To
T6153 159-168 JJ denotes deficient
T6605 2552-2562 JJ denotes peritoneal
T6604 2546-2551 VBG denotes using
T6603 2537-2545 VBN denotes obtained
T6548 2260-2262 NNP denotes 1C
T6547 2253-2259 NN denotes figure
T6546 2252-2253 -LRB- denotes (
T6545 2246-2251 NNS denotes cells
T6544 2241-2245 NN denotes type
T6543 2236-2240 JJ denotes wild
T6542 2233-2235 TO denotes to
T6541 2224-2232 VBN denotes compared
T6540 2219-2223 NNP denotes BMDM
T6539 2209-2218 JJ denotes deficient
T6538 2205-2208 CD denotes A20
T6537 2202-2204 IN denotes in
T6536 2196-2201 NN denotes point
T6535 2191-2195 NN denotes time
T6534 2183-2190 JJR denotes earlier
T6533 2180-2182 DT denotes an
T6532 2177-2179 IN denotes at
T6531 2169-2176 NN denotes maximum
T6530 2165-2168 PRP$ denotes its
T6529 2157-2164 VBD denotes reached
T6528 2143-2156 NN denotes translocation
T6527 2135-2142 JJ denotes nuclear
T6637 2754-2755 . denotes .
T6636 2743-2754 NNS denotes macrophages
T6635 2735-2742 JJ denotes primary
T6634 2732-2734 IN denotes in
T6633 2721-2731 NN denotes activation
T6632 2716-2720 JJ denotes IRF3
T6631 2712-2715 CC denotes and
T6630 2706-2711 NN denotes NF-κB
T6629 2692-2705 JJ denotes RIG-I-induced
T6628 2689-2691 IN denotes of
T6627 2678-2688 NN denotes regulation
T6626 2669-2677 JJ denotes negative
T6625 2665-2668 DT denotes the
T6624 2662-2664 IN denotes in
T6623 2657-2661 NN denotes role
T6622 2647-2656 JJ denotes important
T6621 2644-2646 DT denotes an
T6620 2638-2643 VBZ denotes plays
T6619 2634-2637 NNP denotes A20
T6618 2629-2633 IN denotes that
T6617 2617-2628 VBP denotes demonstrate
T6616 2609-2616 NNS denotes results
T6615 2603-2608 DT denotes these
T6614 2601-2602 , denotes ,
T6613 2593-2601 RB denotes Together
T6612 2591-2592 . denotes .
T6611 2590-2591 -RRB- denotes )
T6610 2585-2590 VBN denotes shown
T6609 2581-2584 RB denotes not
T6608 2576-2580 NNS denotes data
T6607 2575-2576 -LRB- denotes (
T6606 2563-2574 NNS denotes macrophages
R4344 T6155 T6150 conj macrophages,experiments
R4345 T6156 T6148 punct .,performed
R4347 T6157 T6162 mark Since,die
R4348 T6158 T6161 nmod A20,mice
R4349 T6159 T6161 amod full,mice
R4351 T6160 T6161 compound knockout,mice
R4352 T6161 T6162 nsubj mice,die
R4353 T6162 T6176 advcl die,generated
R4355 T6163 T6162 advmod prematurely,die
R4356 T6164 T6162 prep as,die
R4358 T6165 T6166 det a,result
R4359 T6166 T6164 pobj result,as
R4360 T6167 T6166 prep of,result
R4361 T6168 T6170 amod severe,inflammation
R4363 T6169 T6170 amod multi-organ,inflammation
R4364 T6170 T6167 pobj inflammation,of
R4365 T6171 T6173 nmod [,]
R4367 T6172 T6173 nummod 37,]
R4368 T6173 T6170 appos ],inflammation
R4370 T6174 T6176 punct ",",generated
R4371 T6175 T6176 nsubj we,generated
R4372 T6176 T6176 ROOT generated,generated
R4374 T6177 T6176 dobj mice,generated
R4421 T6210 T6209 pobj control,under
R4422 T6211 T6210 prep of,control
R4423 T6212 T6215 det the,promoter
R4425 T6213 T6214 compound lysozyme,M
R4426 T6214 T6215 compound M,promoter
R4427 T6215 T6211 pobj promoter,of
R4429 T6216 T6216 ROOT leads,leads
R4430 T6217 T6216 prep to,leads
R4431 T6218 T6219 amod specific,deletion
R4432 T6219 T6217 pobj deletion,to
R4433 T6220 T6219 prep in,deletion
R4434 T6221 T6222 amod myeloid,cells
R4435 T6222 T6220 pobj cells,in
R4437 T6223 T6216 cc and,leads
R4438 T6224 T6216 conj allowed,leads
R4439 T6225 T6227 nsubj us,generate
R4441 T6226 T6227 aux to,generate
R4442 T6227 T6224 ccomp generate,allowed
R4443 T6228 T6229 compound myeloid,cell
R4444 T6229 T6233 amod cell,mice
R4446 T6230 T6233 amod specific,mice
R4447 T6231 T6233 compound A20,mice
R4448 T6232 T6233 compound knockout,mice
R4450 T6233 T6227 dobj mice,generate
R4451 T6234 T6227 conj [,generate
R4452 T6235 T6236 nummod 48,]
R4456 T6236 T6234 dobj ],[
R4457 T6237 T6216 punct .,leads
R4459 T6238 T6239 aux To,stimulate
R4460 T6239 T6245 advcl stimulate,transfected
R4461 T6240 T6242 det the,receptor
R4463 T6241 T6242 compound RIG-I,receptor
R4464 T6242 T6239 dobj receptor,stimulate
R4465 T6243 T6245 punct ",",transfected
R4467 T6244 T6245 nsubj we,transfected
R4468 T6245 T6245 ROOT transfected,transfected
R4469 T6246 T6247 compound A20myel-KO,BMDM
R4471 T6247 T6245 dobj BMDM,transfected
R4472 T6248 T6247 cc and,BMDM
R4473 T6249 T6250 amod wild,type
R4475 T6250 T6247 conj type,BMDM
R4476 T6251 T6252 compound control,cells
R4477 T6252 T6250 dobj cells,type
R4479 T6253 T6252 prep with,cells
R4480 T6254 T6255 amod minimal,amounts
R4481 T6255 T6253 pobj amounts,with
R4482 T6256 T6255 prep of,amounts
R4517 T6280 T6275 cc than,bind
R4518 T6281 T6284 nummod MDA5,]
R4520 T6282 T6284 nmod [,]
R4521 T6283 T6284 nummod 57,]
R4522 T6284 T6275 conj ],bind
R4523 T6285 T6245 punct .,transfected
R4525 T6286 T6298 prep Of,was
R4526 T6287 T6286 pobj note,Of
R4527 T6288 T6298 punct ",",was
R4529 T6289 T6290 det this,concentration
R4530 T6290 T6298 nsubj concentration,was
R4531 T6291 T6290 prep of,concentration
R4532 T6292 T6291 pobj poly,of
R4533 T6293 T6296 punct (,C
R4534 T6294 T6296 nsubj I,C
R4535 T6295 T6296 punct :,C
R4537 T6296 T6290 appos C,concentration
R4538 T6297 T6296 punct ),C
R4539 T6298 T6298 ROOT was,was
R4541 T6299 T6298 acomp unable,was
R4542 T6300 T6301 aux to,induce
R4544 T6301 T6299 xcomp induce,unable
R4545 T6302 T6305 amod significant,NF-κB
R4546 T6303 T6305 nummod TLR3,NF-κB
R4547 T6304 T6305 amod dependent,NF-κB
R4549 T6305 T6301 dobj NF-κB,induce
R4550 T6306 T6305 cc and,NF-κB
R4551 T6307 T6308 amod IRF3,activation
R4553 T6308 T6305 conj activation,NF-κB
R4554 T6309 T6308 cc or,activation
R4555 T6310 T6308 conj cytokine,activation
R4557 T6311 T6308 conj production,activation
R4558 T6312 T6315 punct (,shown
R4561 T6313 T6315 nsubjpass data,shown
R4562 T6314 T6315 neg not,shown
R4564 T6315 T6298 conj shown,was
R4565 T6316 T6315 punct ),shown
R4566 T6317 T6298 punct .,was
R4567 T6129 T6130 aux To,study
R4568 T6318 T6319 mark As,expected
R4569 T6319 T6328 advcl expected,induced
R4570 T6320 T6328 punct ",",induced
R4571 T6130 T6148 advcl study,performed
R4572 T6321 T6327 nmod poly,transfection
R4573 T6322 T6327 punct (,transfection
R4574 T6323 T6327 nmod I,transfection
R4575 T6131 T6132 det the,effect
R4576 T6324 T6325 punct :,C
R4577 T6325 T6323 appos C,I
R4578 T6326 T6327 punct ),transfection
R4579 T6132 T6130 dobj effect,study
R4580 T6327 T6328 nsubj transfection,induced
R4581 T6328 T6328 ROOT induced,induced
R4582 T6329 T6331 det the,expression
R4583 T6330 T6331 amod rapid,expression
R4584 T6331 T6328 dobj expression,induced
R4585 T6332 T6331 prep of,expression
R4586 T6133 T6132 prep of,effect
R4587 T6134 T6135 advmod endogenously,expressed
R4588 T6135 T6136 amod expressed,A20
R4589 T6136 T6133 pobj A20,of
R4590 T6333 T6332 pobj A20,of
R4591 T6334 T6328 prep in,induced
R4592 T6335 T6336 amod wild,type
R4593 T6336 T6334 pobj type,in
R4594 T6137 T6132 prep on,effect
R4595 T6337 T6328 punct ",",induced
R4596 T6338 T6328 cc but,induced
R4597 T6138 T6139 amod RIG-I-induced,signaling
R4598 T6339 T6340 neg not,in
R4599 T6340 T6340 ROOT in,in
R4600 T6341 T6342 compound A20myel-KO,BMDM
R4601 T6342 T6340 pobj BMDM,in
R4602 T6430 T6426 appos BMDM,C
R4603 T6343 T6345 punct (,1B
R4604 T6344 T6345 compound figure,1B
R4605 T6345 T6328 conj 1B,induced
R4606 T6346 T6348 punct ",",panel
R4607 T6431 T6426 punct ",",C
R4608 T6347 T6348 amod upper,panel
R4609 T6348 T6345 appos panel,1B
R4610 T6349 T6345 punct ),1B
R4611 T6432 T6420 advcl reaching,enhanced
R4612 T6350 T6328 punct .,induced
R4613 T6351 T6363 prep At,observed
R4614 T6352 T6353 amod early,time
R4615 T6353 T6351 pobj time,At
R4616 T6433 T6434 det a,maximum
R4617 T6354 T6363 nsubjpass points,observed
R4618 T6355 T6359 punct ",",forms
R4619 T6356 T6357 advmod slightly,slower
R4620 T6434 T6432 dobj maximum,reaching
R4621 T6357 T6359 amod slower,forms
R4622 T6358 T6359 amod migrating,forms
R4623 T6359 T6363 nsubjpass forms,observed
R4624 T6435 T6432 prep at,reaching
R4625 T6360 T6359 prep of,forms
R4626 T6361 T6360 pobj A20,of
R4627 T6362 T6363 auxpass were,observed
R4628 T6436 T6437 amod earlier,time
R4629 T6363 T6363 ROOT observed,observed
R4630 T6364 T6363 punct ",",observed
R4631 T6365 T6363 advcl indicating,observed
R4632 T6366 T6368 mark that,undergoes
R4633 T6367 T6368 nsubj A20,undergoes
R4634 T6368 T6365 ccomp undergoes,indicating
R4635 T6369 T6372 det a,modification
R4636 T6437 T6438 compound time,points
R4637 T6370 T6371 advmod yet,unknown
R4638 T6371 T6372 amod unknown,modification
R4639 T6372 T6368 dobj modification,undergoes
R4640 T6373 T6372 prep upon,modification
R4641 T6438 T6435 pobj points,at
R4642 T6374 T6373 pobj poly,upon
R4643 T6375 T6372 punct (,modification
R4644 T6376 T6378 nsubj I,C
R4645 T6439 T6420 prep compared,enhanced
R4646 T6377 T6378 punct :,C
R4647 T6378 T6372 appos C,modification
R4648 T6379 T6378 punct ),C
R4649 T6440 T6439 prep to,compared
R4650 T6380 T6372 appos transfection,modification
R4651 T6381 T6363 punct .,observed
R4652 T6382 T6391 prep Compared,showed
R4653 T6441 T6443 amod wild,cells
R4654 T6383 T6382 prep to,Compared
R4655 T6384 T6385 amod wild,type
R4656 T6385 T6386 compound type,BMBM
R4657 T6442 T6443 compound type,cells
R4658 T6386 T6383 pobj BMBM,to
R4659 T6387 T6386 punct ",",BMBM
R4660 T6388 T6390 amod A20,cells
R4661 T6443 T6440 pobj cells,to
R4662 T6389 T6390 amod deficient,cells
R4663 T6444 T6446 punct (,1C
R4664 T6390 T6391 nsubj cells,showed
R4665 T6445 T6446 compound figure,1C
R4666 T6391 T6391 ROOT showed,showed
R4667 T6392 T6394 amod enhanced,activation
R4668 T6393 T6394 compound NF-κB,activation
R4669 T6446 T6443 appos 1C,cells
R4670 T6394 T6391 dobj activation,showed
R4671 T6395 T6396 mark as,indicated
R4672 T6396 T6391 advcl indicated,showed
R4673 T6447 T6420 punct ),enhanced
R4674 T6397 T6396 agent by,indicated
R4675 T6398 T6399 amod increased,phosphorylation
R4676 T6448 T6420 punct .,enhanced
R4677 T6399 T6397 pobj phosphorylation,by
R4678 T6400 T6399 cc and,phosphorylation
R4679 T6401 T6402 amod sustained,degradation
R4680 T6449 T6451 nsubjpass IRF3,known
R4681 T6402 T6399 conj degradation,phosphorylation
R4682 T6403 T6402 prep of,degradation
R4683 T6404 T6403 pobj IκBα,of
R4684 T6405 T6407 punct (,1B
R4685 T6406 T6407 compound figure,1B
R4686 T6407 T6404 appos 1B,IκBα
R4687 T6450 T6451 auxpass is,known
R4688 T6408 T6407 punct ),1B
R4689 T6409 T6391 punct .,showed
R4690 T6410 T6420 advmod Furthermore,enhanced
R4691 T6411 T6420 punct ",",enhanced
R4692 T6451 T6451 ROOT known,known
R4693 T6412 T6413 amod nuclear,translocation
R4694 T6413 T6420 nsubjpass translocation,enhanced
R4695 T6452 T6454 aux to,activated
R4696 T6414 T6413 prep of,translocation
R4697 T6415 T6418 det the,subunit
R4698 T6416 T6418 nummod p65,subunit
R4699 T6417 T6418 compound NF-κB,subunit
R4700 T6453 T6454 auxpass be,activated
R4701 T6418 T6414 pobj subunit,of
R4702 T6419 T6420 auxpass was,enhanced
R4703 T6420 T6420 ROOT enhanced,enhanced
R4704 T6454 T6451 xcomp activated,known
R4705 T6421 T6420 prep in,enhanced
R4706 T6422 T6421 pobj poly,in
R4707 T6423 T6426 punct (,C
R4708 T6455 T6454 prep upon,activated
R4709 T6424 T6426 nsubj I,C
R4710 T6425 T6426 punct :,C
R4711 T6426 T6420 parataxis C,enhanced
R4712 T6427 T6426 punct ),C
R4713 T6456 T6455 pobj phosphorylation,upon
R4714 T6428 T6430 amod transfected,BMDM
R4715 T6429 T6430 compound A20myel-KO,BMDM
R4716 T6457 T6456 prep of,phosphorylation
R4717 T6458 T6459 det a,series
R4718 T6459 T6457 pobj series,of
R4719 T6527 T6528 amod nuclear,translocation
R4720 T6528 T6529 nsubj translocation,reached
R4721 T6460 T6459 prep of,series
R4722 T6529 T6529 ROOT reached,reached
R4723 T6530 T6531 poss its,maximum
R4724 T6531 T6529 dobj maximum,reached
R4725 T6461 T6462 compound carboxyl,terminal
R4726 T6532 T6529 prep at,reached
R4727 T6533 T6536 det an,point
R4728 T6534 T6535 amod earlier,time
R4729 T6462 T6464 compound terminal,residues
R4730 T6535 T6536 compound time,point
R4731 T6536 T6532 pobj point,at
R4732 T6463 T6464 compound serine,residues
R4733 T6537 T6529 prep in,reached
R4734 T6538 T6540 nummod A20,BMDM
R4735 T6539 T6540 amod deficient,BMDM
R4736 T6540 T6537 pobj BMDM,in
R4737 T6541 T6529 prep compared,reached
R4738 T6542 T6541 prep to,compared
R4739 T6464 T6460 pobj residues,of
R4740 T6543 T6545 amod wild,cells
R4741 T6544 T6545 compound type,cells
R4742 T6545 T6542 pobj cells,to
R4743 T6546 T6548 punct (,1C
R4744 T6465 T6459 prep by,series
R4745 T6547 T6548 compound figure,1C
R4746 T6466 T6468 det the,kinases
R4747 T6467 T6468 amod IKK-like,kinases
R4751 T6468 T6465 pobj kinases,by
R4755 T6469 T6468 appos TBK1,kinases
R4759 T6470 T6469 cc and,TBK1
R4763 T6471 T6472 compound IKKε,[
R4766 T6472 T6469 conj [,TBK1
R4770 T6473 T6474 nummod 58,]
R4771 T6565 T6566 det the,expression
R4772 T6566 T6564 dobj expression,control
R4773 T6567 T6566 prep of,expression
R4774 T6568 T6567 pobj IFNβ,of
R4775 T6474 T6474 ROOT ],]
R4776 T6569 T6564 punct .,control
R4777 T6570 T6586 prep In,secreted
R4778 T6571 T6570 pobj line,In
R4779 T6475 T6474 punct ",",]
R4780 T6572 T6571 prep with,line
R4781 T6573 T6575 det the,activation
R4782 T6476 T6474 acl leading,]
R4783 T6574 T6575 amod enhanced,activation
R4784 T6575 T6572 pobj activation,with
R4785 T6576 T6575 prep of,activation
R4786 T6577 T6576 pobj NF-κB,of
R4787 T6578 T6577 cc and,NF-κB
R4788 T6579 T6577 conj IRF3,NF-κB
R4789 T6580 T6581 mark as,described
R4790 T6477 T6476 prep to,leading
R4791 T6581 T6586 advcl described,secreted
R4792 T6582 T6581 prep above,described
R4793 T6583 T6586 punct ",",secreted
R4794 T6584 T6585 compound A20myel-KO,BMDM
R4795 T6478 T6479 poss its,dimerization
R4796 T6585 T6586 nsubj BMDM,secreted
R4797 T6586 T6586 ROOT secreted,secreted
R4798 T6479 T6477 pobj dimerization,to
R4799 T6587 T6588 amod increased,amounts
R4800 T6588 T6586 dobj amounts,secreted
R4801 T6589 T6588 prep of,amounts
R4802 T6480 T6479 cc and,dimerization
R4803 T6590 T6589 pobj IL-6,of
R4804 T6591 T6590 punct ",",IL-6
R4805 T6592 T6590 conj TNF,IL-6
R4806 T6481 T6482 amod subsequent,translocation
R4807 T6593 T6592 cc and,TNF
R4808 T6594 T6592 conj IFNβ,TNF
R4809 T6595 T6596 punct (,figure
R4810 T6482 T6479 conj translocation,dimerization
R4811 T6596 T6597 nsubj figure,1D
R4812 T6597 T6588 acl 1D,amounts
R4813 T6598 T6588 punct ),amounts
R4814 T6483 T6477 prep to,to
R4815 T6599 T6586 punct .,secreted
R4816 T6600 T6601 amod Similar,results
R4817 T6601 T6603 nsubjpass results,obtained
R4818 T6602 T6603 auxpass were,obtained
R4819 T6484 T6485 det the,nucleus
R4820 T6485 T6483 pobj nucleus,to
R4821 T6486 T6477 pobj [,to
R4822 T6603 T6603 ROOT obtained,obtained
R4823 T6487 T6488 nummod 59,]
R4824 T6604 T6603 advcl using,obtained
R4825 T6605 T6606 amod peritoneal,macrophages
R4826 T6488 T6486 dobj ],[
R4827 T6606 T6604 dobj macrophages,using
R4828 T6607 T6606 punct (,macrophages
R4829 T6608 T6606 appos data,macrophages
R4830 T6609 T6610 neg not,shown
R4831 T6489 T6451 punct .,known
R4832 T6610 T6608 acl shown,data
R4833 T6490 T6504 advcl Using,detected
R4837 T6491 T6490 dobj immunoblotting,Using
R4841 T6492 T6491 prep with,immunoblotting
R4845 T6493 T6494 det an,antibody
R4848 T6494 T6492 pobj antibody,with
R4852 T6495 T6494 acl directed,antibody
R4855 T6496 T6495 prep against,directed
R4856 T6497 T6498 compound phosphorylated,Ser396
R4857 T6498 T6496 pobj Ser396,against
R4858 T6627 T6624 pobj regulation,in
R4859 T6628 T6627 prep of,regulation
R4860 T6499 T6498 punct ",",Ser396
R4861 T6629 T6630 amod RIG-I-induced,NF-κB
R4862 T6630 T6628 pobj NF-κB,of
R4863 T6631 T6630 cc and,NF-κB
R4864 T6500 T6502 amod maximum,phosphorylation
R4865 T6632 T6633 amod IRF3,activation
R4866 T6633 T6630 conj activation,NF-κB
R4867 T6634 T6633 prep in,activation
R4868 T6501 T6502 nummod IRF3,phosphorylation
R4869 T6635 T6636 amod primary,macrophages
R4870 T6636 T6634 pobj macrophages,in
R4871 T6502 T6498 appos phosphorylation,Ser396
R4872 T6637 T6617 punct .,demonstrate
R4873 T6503 T6504 auxpass was,detected
R4874 T6504 T6504 ROOT detected,detected
R4875 T6505 T6504 prep at,detected
R4876 T6506 T6507 amod earlier,time
R4877 T6507 T6505 pobj time,at
R4878 T6508 T6512 nsubj points,compared
R4879 T6509 T6508 prep in,points
R4880 T6510 T6511 compound A20myel-KO,BMDM
R4881 T6511 T6509 pobj BMDM,in
R4882 T6512 T6504 prep compared,detected
R4883 T6513 T6512 prep to,compared
R4884 T6514 T6515 amod wild,type
R4885 T6515 T6516 compound type,BMDM
R4886 T6516 T6513 pobj BMDM,to
R4887 T6517 T6519 punct (,1B
R4888 T6518 T6519 compound figure,1B
R4889 T6519 T6516 appos 1B,BMDM
R4890 T6520 T6519 punct ),1B
R4891 T6521 T6504 punct .,detected
R4892 T6522 T6529 advcl Similar,reached
R4893 T6523 T6524 aux to,p65
R4894 T6524 T6522 xcomp p65,Similar
R4895 T6525 T6524 punct ",",p65
R4896 T6526 T6524 dep IRF3,p65
R4324 T6139 T6137 pobj signaling,on
R4325 T6140 T6130 prep in,study
R4327 T6141 T6145 det a,context
R4328 T6142 T6143 advmod more,immunological
R4329 T6143 T6145 amod immunological,context
R4330 T6144 T6145 amod relevant,context
R4331 T6145 T6140 pobj context,in
R4333 T6146 T6148 punct ",",performed
R4334 T6147 T6148 nsubj we,performed
R4335 T6148 T6148 ROOT performed,performed
R4336 T6149 T6150 amod further,experiments
R4338 T6150 T6148 dobj experiments,performed
R4339 T6151 T6150 prep in,experiments
R4340 T6152 T6151 pobj A20,in
R4342 T6153 T6155 amod deficient,macrophages
R4343 T6154 T6155 amod primary,macrophages
R4377 T6178 T6177 acl carrying,mice
R4378 T6179 T6182 det a,allele
R4380 T6180 T6182 amod conditional,allele
R4381 T6181 T6182 compound A20,allele
R4382 T6182 T6178 dobj allele,carrying
R4383 T6183 T6191 prep in,flanked
R4384 T6184 T6183 pobj which,in
R4386 T6185 T6186 compound exon,IV
R4387 T6186 T6191 nsubjpass IV,flanked
R4388 T6187 T6186 cc and,IV
R4390 T6188 T6189 compound exon,V
R4391 T6189 T6186 conj V,IV
R4392 T6190 T6191 auxpass were,flanked
R4394 T6191 T6182 relcl flanked,allele
R4395 T6192 T6191 agent by,flanked
R4396 T6193 T6195 nummod two,sites
R4399 T6194 T6195 compound loxP,sites
R4401 T6195 T6192 pobj sites,by
R4402 T6196 T6195 appos [,sites
R4403 T6197 T6198 nummod 56,]
R4405 T6198 T6196 appos ],[
R4406 T6199 T6176 punct .,generated
R4407 T6200 T6216 csubj Crossing,leads
R4409 T6201 T6202 det these,mice
R4410 T6202 T6200 dobj mice,Crossing
R4412 T6203 T6200 prep with,Crossing
R4413 T6204 T6205 amod transgenic,mice
R4414 T6205 T6203 pobj mice,with
R4416 T6206 T6205 acl expressing,mice
R4417 T6207 T6208 compound Cre,recombinase
R4418 T6208 T6206 dobj recombinase,expressing
R4419 T6209 T6206 prep under,expressing
R4484 T6257 T6259 amod low,weight
R4485 T6258 T6259 amod molecular,weight
R4487 T6259 T6256 pobj weight,of
R4488 T6260 T6259 punct (,weight
R4490 T6261 T6259 appos LMW,weight
R4491 T6262 T6263 punct ),poly
R4492 T6263 T6259 appos poly,weight
R4494 T6264 T6267 punct (,C
R4495 T6265 T6267 nsubj I,C
R4496 T6266 T6267 punct :,C
R4498 T6267 T6263 parataxis C,poly
R4499 T6268 T6267 punct ),C
R4500 T6269 T6267 punct ",",C
R4501 T6270 T6272 nsubjpass which,known
R4503 T6271 T6272 auxpass is,known
R4506 T6272 T6267 relcl known,C
R4508 T6273 T6275 aux to,bind
R4509 T6274 T6275 advmod preferentially,bind
R4510 T6275 T6272 xcomp bind,known
R4512 T6276 T6275 cc and,bind
R4513 T6277 T6275 conj activate,bind
R4514 T6278 T6277 dobj RIG-I,activate
R4516 T6279 T6280 advmod rather,than
R4748 T6548 T6545 appos 1C,cells
R4749 T6549 T6545 punct ),cells
R4750 T6550 T6529 punct .,reached
R4752 T6551 T6552 nsubj NF-κB,controls
R4753 T6552 T6552 ROOT controls,controls
R4754 T6553 T6554 det the,expression
R4756 T6554 T6552 dobj expression,controls
R4757 T6555 T6554 prep of,expression
R4758 T6556 T6555 pobj IL-6,of
R4760 T6557 T6556 cc and,IL-6
R4761 T6558 T6556 conj TNF,IL-6
R4762 T6559 T6552 punct ",",controls
R4764 T6560 T6552 cc and,controls
R4765 T6561 T6564 nsubj NF-κB,control
R4767 T6562 T6561 cc and,NF-κB
R4768 T6563 T6561 conj IRF3,NF-κB
R4769 T6564 T6552 conj control,controls
R4834 T6611 T6606 punct ),macrophages
R4835 T6612 T6603 punct .,obtained
R4836 T6613 T6617 advmod Together,demonstrate
R4838 T6614 T6617 punct ",",demonstrate
R4839 T6615 T6616 det these,results
R4840 T6616 T6617 nsubj results,demonstrate
R4842 T6617 T6617 ROOT demonstrate,demonstrate
R4843 T6618 T6620 mark that,plays
R4844 T6619 T6620 nsubj A20,plays
R4846 T6620 T6617 ccomp plays,demonstrate
R4847 T6621 T6623 det an,role
R4849 T6622 T6623 amod important,role
R4850 T6623 T6620 dobj role,plays
R4851 T6624 T6623 prep in,role
R4853 T6625 T6627 det the,regulation
R4854 T6626 T6627 amod negative,regulation

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T7132 2721-2731 Positive_regulation denotes activation
T7131 2721-2731 Positive_regulation denotes activation
T7130 2716-2720 Protein denotes IRF3
T7129 2706-2711 Protein denotes NF-κB
T7128 2380-2388 Positive_regulation denotes enhanced
T7127 2380-2388 Positive_regulation denotes enhanced
T7126 2463-2472 Positive_regulation denotes increased
T7125 2463-2472 Positive_regulation denotes increased
T7124 2463-2472 Positive_regulation denotes increased
T7123 2454-2462 Localization denotes secreted
T7122 2454-2462 Localization denotes secreted
T7121 2454-2462 Localization denotes secreted
T7120 2389-2399 Positive_regulation denotes activation
T7119 2389-2399 Positive_regulation denotes activation
T7118 2498-2502 Protein denotes IFNβ
T7117 2490-2493 Protein denotes TNF
T7116 2484-2488 Protein denotes IL-6
T7115 2413-2417 Protein denotes IRF3
T7114 2403-2408 Protein denotes NF-κB
T7113 2331-2338 Regulation denotes control
T7112 2331-2338 Regulation denotes control
T7111 2271-2279 Regulation denotes controls
T7110 2271-2279 Regulation denotes controls
T7109 2343-2353 Gene_expression denotes expression
T7108 2284-2294 Gene_expression denotes expression
T7107 2284-2294 Gene_expression denotes expression
T7106 2357-2361 Protein denotes IFNβ
T7105 2326-2330 Protein denotes IRF3
T7104 2316-2321 Protein denotes NF-κB
T7103 2307-2310 Protein denotes TNF
T7102 2298-2302 Protein denotes IL-6
T7101 2265-2270 Protein denotes NF-κB
T7100 2143-2156 Localization denotes translocation
T7099 2135-2142 Entity denotes nuclear
T7098 2130-2134 Protein denotes IRF3
T7097 2125-2128 Protein denotes p65
T7096 2003-2018 Phosphorylation denotes phosphorylation
T7095 1998-2002 Protein denotes IRF3
T7094 1898-1905 Entity denotes nucleus
T7093 1710-1719 Positive_regulation denotes activated
T7092 1814-1818 Protein denotes TBK1
T7091 1797-1813 Protein denotes IKK-like kinases
T7090 1690-1694 Protein denotes IRF3
T7089 1556-1564 Positive_regulation denotes enhanced
T7088 1556-1564 Positive_regulation denotes enhanced
T7085 1505-1512 Entity denotes nuclear
T7084 1541-1543 Protein denotes κB
T7083 1534-1540 Protein denotes p65 NF
T7082 1419-1428 Positive_regulation denotes increased
T7081 1419-1428 Positive_regulation denotes increased
T7080 1392-1402 Positive_regulation denotes activation
T7079 1377-1385 Positive_regulation denotes enhanced
T7078 1459-1470 Protein_catabolism denotes degradation
T7077 1429-1444 Phosphorylation denotes phosphorylation
T7076 1392-1402 Positive_regulation denotes activation
T7075 1474-1478 Protein denotes IκBα
T7074 1386-1391 Protein denotes NF-κB
T7073 1057-1064 Positive_regulation denotes induced
T7072 1075-1085 Gene_expression denotes expression
T7071 1089-1092 Protein denotes A20
T7070 920-926 Positive_regulation denotes induce
T7069 920-926 Positive_regulation denotes induce
T7068 969-979 Positive_regulation denotes activation
T7067 969-979 Positive_regulation denotes activation
T7066 964-968 Protein denotes IRF3
T7065 939-959 Protein denotes TLR3 dependent NF-κB
T7064 827-835 Positive_regulation denotes activate
T7063 634-643 Positive_regulation denotes stimulate
T7062 836-841 Protein denotes RIG-I
T7061 648-662 Protein denotes RIG-I receptor
T7060 479-486 Regulation denotes control
T7059 446-456 Gene_expression denotes expressing
T7058 494-513 Protein denotes lysozyme M promoter
T7057 457-472 Protein denotes Cre recombinase
T7056 329-339 Protein denotes A20 allele
T7087 1513-1526 Localization denotes translocation
T7086 1513-1526 Localization denotes translocation
R5104 T7086 T7085 ToLoc translocation,nuclear
R5107 T7086 T7088 themeOf translocation,enhanced
R5110 T7087 T7085 ToLoc translocation,nuclear
R5111 T7087 T7089 themeOf translocation,enhanced
R5113 T7090 T7093 themeOf IRF3,activated
R5117 T7093 T7092 Cause activated,TBK1
R5120 T7095 T7096 themeOf IRF3,phosphorylation
R5121 T7057 T7059 themeOf Cre recombinase,expressing
R5122 T7059 T7060 themeOf expressing,control
R5123 T7098 T7100 themeOf IRF3,translocation
R5124 T7060 T7058 Cause control,lysozyme M promoter
R5125 T7061 T7063 themeOf RIG-I receptor,stimulate
R5126 T7062 T7064 themeOf RIG-I,activate
R5127 T7100 T7099 ToLoc translocation,nuclear
R5128 T7065 T7067 themeOf TLR3 dependent NF-κB,activation
R5129 T7066 T7068 themeOf IRF3,activation
R5130 T7067 T7069 themeOf activation,induce
R5131 T7102 T7107 themeOf IL-6,expression
R5132 T7068 T7070 themeOf activation,induce
R5133 T7071 T7072 themeOf A20,expression
R5134 T7103 T7108 themeOf TNF,expression
R5135 T7072 T7073 themeOf expression,induced
R5136 T7074 T7076 themeOf NF-κB,activation
R5137 T7106 T7109 themeOf IFNβ,expression
R5138 T7075 T7077 themeOf IκBα,phosphorylation
R5139 T7075 T7078 themeOf IκBα,degradation
R5140 T7076 T7079 themeOf activation,enhanced
R5141 T7077 T7081 themeOf phosphorylation,increased
R5142 T7078 T7082 themeOf degradation,increased
R5143 T7079 T7080 themeOf enhanced,activation
R5144 T7083 T7086 themeOf p65 NF,translocation
R5145 T7107 T7110 themeOf expression,controls
R5146 T7084 T7087 themeOf κB,translocation
R5147 T7108 T7111 themeOf expression,controls
R5148 T7109 T7112 themeOf expression,control
R5149 T7109 T7113 themeOf expression,control
R5150 T7110 T7101 Cause controls,NF-κB
R5151 T7111 T7101 Cause controls,NF-κB
R5152 T7112 T7104 Cause control,NF-κB
R5155 T7113 T7105 Cause control,IRF3
R5158 T7114 T7119 themeOf NF-κB,activation
R5159 T7115 T7120 themeOf IRF3,activation
R5160 T7116 T7121 themeOf IL-6,secreted
R5163 T7116 T7124 themeOf IL-6,increased
R5165 T7117 T7122 themeOf TNF,secreted
R5169 T7117 T7125 themeOf TNF,increased
R5171 T7118 T7123 themeOf IFNβ,secreted
R5178 T7118 T7126 themeOf IFNβ,increased
R5179 T7119 T7127 themeOf activation,enhanced
R5181 T7120 T7128 themeOf activation,enhanced
R5184 T7129 T7131 themeOf NF-κB,activation
R5194 T7130 T7132 themeOf IRF3,activation

testone

Id Subject Object Predicate Lexical cue
T4571 2463-2472 Positive_regulation denotes increased
T4570 2454-2462 Localization denotes secreted
T4569 2343-2353 Gene_expression denotes expression
T4568 2331-2338 Regulation denotes control
T4567 2284-2294 Gene_expression denotes expression
T4566 2271-2279 Regulation denotes controls
T4565 2209-2218 Negative_regulation denotes deficient
T4564 2143-2156 Localization denotes translocation
T4563 2135-2142 Entity denotes nuclear
T4562 2003-2018 Phosphorylation denotes phosphorylation
T4561 1967-1981 Phosphorylation denotes phosphorylated
T4560 1898-1905 Entity denotes nucleus
T4559 1849-1861 Binding denotes dimerization
T4558 1774-1789 Entity denotes serine residues
T4557 1725-1740 Phosphorylation denotes phosphorylation
T4556 1578-1589 Gene_expression denotes transfected
T4555 1556-1564 Positive_regulation denotes enhanced
T4554 1513-1526 Localization denotes translocation
T4553 1505-1512 Entity denotes nuclear
T4552 1459-1470 Protein_catabolism denotes degradation
T4551 1429-1444 Phosphorylation denotes phosphorylation
T4550 1419-1428 Positive_regulation denotes increased
T4549 1354-1363 Negative_regulation denotes deficient
T4548 1075-1085 Gene_expression denotes expression
T4547 1057-1064 Positive_regulation denotes induced
T4546 920-926 Positive_regulation denotes induce
T4545 818-822 Binding denotes bind
T4544 446-456 Gene_expression denotes expressing
T4543 159-168 Negative_regulation denotes deficient
T4542 36-45 Gene_expression denotes expressed
T4522 2716-2720 Protein denotes IRF3
T4521 2692-2697 Protein denotes RIG-I
T4520 2498-2502 Protein denotes IFNβ
T4519 2490-2493 Protein denotes TNF
T4518 2484-2488 Protein denotes IL-6
T4517 2413-2417 Protein denotes IRF3
T4516 2357-2361 Protein denotes IFNβ
T4515 2326-2330 Protein denotes IRF3
T4514 2307-2310 Protein denotes TNF
T4513 2298-2302 Protein denotes IL-6
T4512 2130-2134 Protein denotes IRF3
T4511 2125-2128 Protein denotes p65
T4510 1998-2002 Protein denotes IRF3
T4509 1823-1827 Protein denotes IKKε
T4508 1814-1818 Protein denotes TBK1
T4507 1690-1694 Protein denotes IRF3
T4506 1534-1537 Protein denotes p65
T4505 1474-1478 Protein denotes IκBα
T4504 964-968 Protein denotes IRF3
T4503 939-943 Protein denotes TLR3
T4502 854-858 Protein denotes MDA5
T4501 836-841 Protein denotes RIG-I
T4500 648-653 Protein denotes RIG-I
T4499 53-58 Protein denotes RIG-I
R3132 T4501 T4545 themeOf RIG-I,bind
R3133 T4503 T4546 themeOf TLR3,induce
R3134 T4505 T4552 themeOf IκBα,degradation
R3135 T4505 T4551 themeOf IκBα,phosphorylation
R3136 T4506 T4554 themeOf p65,translocation
R3137 T4507 T4559 themeOf IRF3,dimerization
R3138 T4508 T4559 themeOf TBK1,dimerization
R3139 T4510 T4562 themeOf IRF3,phosphorylation
R3140 T4511 T4564 themeOf p65,translocation
R3141 T4512 T4564 themeOf IRF3,translocation
R3142 T4513 T4567 themeOf IL-6,expression
R3143 T4514 T4567 themeOf TNF,expression
R3144 T4515 T4567 themeOf IRF3,expression
R3145 T4516 T4569 themeOf IFNβ,expression
R3146 T4518 T4570 themeOf IL-6,secreted
R3147 T4520 T4570 themeOf IFNβ,secreted
R3155 T4548 T4547 themeOf expression,induced
R3156 T4549 T4550 causeOf deficient,increased
R3157 T4551 T4550 themeOf phosphorylation,increased
R3158 T4552 T4550 themeOf degradation,increased
R3159 T4553 T4554 locationOf nuclear,translocation
R3160 T4554 T4555 themeOf translocation,enhanced
R3161 T4558 T4557 themeOf serine residues,phosphorylation
R3162 T4558 T4507 partOf serine residues,IRF3
R3163 T4563 T4564 locationOf nuclear,translocation
R3164 T4567 T4566 themeOf expression,controls
R3165 T4569 T4568 themeOf expression,control
R3166 T4570 T4571 themeOf secreted,increased