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test3

Id Subject Object Predicate Lexical cue
T13 5-12 Protein denotes Tnfaip3
T17 5-12 Protein denotes Tnfaip3
T18 14-24 Negative_regulation denotes Deficiency
T21218 25084-25088 Protein denotes IFNα
T21217 25075-25079 Protein denotes IL-6
T21216 25068-25073 Protein denotes MCP-1
T21215 25061-25066 Protein denotes MIP-2
T21214 25057-25059 Protein denotes KC
T21213 24656-24666 Negative_regulation denotes deficiency
T21212 25084-25088 Protein denotes IFNα
T21211 25075-25079 Protein denotes IL-6
T21210 25068-25073 Protein denotes MCP-1
T21209 25061-25066 Protein denotes MIP-2
T21208 25057-25059 Protein denotes KC
T20776 19427-19431 Protein denotes IL-6
T20775 19420-19425 Protein denotes MCP-1
T20774 19413-19418 Protein denotes MIP-2
T20773 19409-19411 Protein denotes KC
T20772 18971-18981 Negative_regulation denotes deficiency
T20771 19427-19431 Protein denotes IL-6
T20770 19420-19425 Protein denotes MCP-1
T20769 19413-19418 Protein denotes MIP-2
T20768 19409-19411 Protein denotes KC
T20278 16518-16522 Protein denotes IFNβ
T20277 16509-16513 Protein denotes IL-6
T20276 16423-16438 Transcription denotes mRNA expression
T20275 16418-16422 Protein denotes IFNβ
T20274 16409-16413 Protein denotes IL-6
T20273 16257-16261 Protein denotes IFNβ
T20272 16249-16252 Protein denotes TNF
T20271 16141-16156 Transcription denotes mRNA expression
T20270 16128-16132 Protein denotes IFNβ
T20269 16122-16126 Protein denotes IL-6
T20268 16518-16522 Protein denotes IFNβ
T20267 16509-16513 Protein denotes IL-6
T20266 16418-16422 Protein denotes IFNβ
T20265 16409-16413 Protein denotes IL-6
T20264 16257-16261 Protein denotes IFNβ
T20263 16249-16252 Protein denotes TNF
T20262 16128-16132 Protein denotes IFNβ
T20261 16122-16126 Protein denotes IL-6
T19325 11285-11295 Protein denotes luciferase
T19327 11372-11376 Protein denotes IRF7
T19326 11346-11356 Gene_expression denotes expressing
T19324 11270-11274 Protein denotes IRF7
T19323 11253-11257 Protein denotes IRF3
T19322 11180-11185 Protein denotes RIG-I
T19321 11149-11153 Protein denotes IRF3
T19320 12335-12339 Protein denotes IFNβ
T19319 12327-12330 Protein denotes TNF
T19318 12310-12314 Protein denotes IL-6
T19317 12229-12233 Protein denotes IFNβ
T19316 12221-12224 Protein denotes TNF
T19315 12215-12219 Protein denotes IL-6
T19314 12116-12120 Protein denotes IRF3
T19313 12108-12111 Protein denotes p65
T19312 11988-11992 Protein denotes IRF3
T19311 11979-11982 Protein denotes p65
T19310 11748-11752 Protein denotes IRF3
T19309 11706-11710 Protein denotes IκBα
T19308 11372-11376 Protein denotes IRF7
T19307 11285-11295 Protein denotes luciferase
T19306 11270-11274 Protein denotes IRF7
T19305 11253-11257 Protein denotes IRF3
T19304 11180-11185 Protein denotes RIG-I
T19303 11149-11153 Protein denotes IRF3
T19346 12335-12339 Protein denotes IFNβ
T19345 12327-12330 Protein denotes TNF
T19344 12310-12314 Protein denotes IL-6
T19343 12229-12233 Protein denotes IFNβ
T19342 12221-12224 Protein denotes TNF
T19341 12215-12219 Protein denotes IL-6
T19340 12145-12154 Gene_expression denotes expressed
T19339 12116-12120 Protein denotes IRF3
T19338 12108-12111 Protein denotes p65
T19337 11988-11992 Protein denotes IRF3
T19336 11979-11982 Protein denotes p65
T19335 11955-11968 Localization denotes translocation
T19334 11947-11954 Entity denotes Nuclear
T19333 11849-11859 Binding denotes recognized
T19332 11753-11768 Phosphorylation denotes phosphorylation
T19331 11748-11752 Protein denotes IRF3
T19330 11731-11742 Protein_catabolism denotes degradation
T19329 11711-11726 Phosphorylation denotes phosphorylation
T19328 11706-11710 Protein denotes IκBα
T18656 41332-41341 Gene_expression denotes expressed
T18655 41106-41111 Protein denotes IFNα4
T18654 41037-41042 Protein denotes CXCL1
T18653 40966-40970 Protein denotes CCL2
T18652 40900-40903 Protein denotes A20
T18651 40831-40835 Protein denotes IFNβ
T18650 40759-40763 Protein denotes IL-6
T18649 41106-41111 Protein denotes IFNα4
T18648 41037-41042 Protein denotes CXCL1
T18647 40966-40970 Protein denotes CCL2
T18646 40900-40903 Protein denotes A20
T18645 40831-40835 Protein denotes IFNβ
T18644 40759-40763 Protein denotes IL-6
T18265 40135-40139 Protein denotes IL-6
T18264 40125-40130 Protein denotes IL-1β
T18263 40120-40123 Protein denotes TNF
T18262 40116-40118 Protein denotes KC
T18261 40109-40114 Protein denotes MCP-1
T18260 39891-39895 Protein denotes IFNβ
T18259 39800-39803 Protein denotes TNF
T18258 39757-39760 Protein denotes TNF
T18257 40135-40139 Protein denotes IL-6
T18256 40125-40130 Protein denotes IL-1β
T18255 40120-40123 Protein denotes TNF
T18254 40116-40118 Protein denotes KC
T18253 40109-40114 Protein denotes MCP-1
T18252 39891-39895 Protein denotes IFNβ
T18251 39800-39803 Protein denotes TNF
T18250 39757-39760 Protein denotes TNF
T17823 39523-39527 Protein denotes CD16
T17822 39495-39499 Protein denotes IFNγ
T17821 39474-39478 Protein denotes CD8α
T17820 39436-39440 Protein denotes Ly6G
T17819 39366-39369 Protein denotes CD3
T17818 39321-39331 Protein denotes Granzyme B
T17817 39302-39307 Protein denotes CD62L
T17816 38886-38905 Protein denotes collagenase type IV
T17815 39523-39527 Protein denotes CD16
T17814 39495-39499 Protein denotes IFNγ
T17813 39474-39478 Protein denotes CD8α
T17812 39436-39440 Protein denotes Ly6G
T17811 39366-39369 Protein denotes CD3
T17810 39321-39331 Protein denotes Granzyme B
T17809 39302-39307 Protein denotes CD62L
T17808 38886-38905 Protein denotes collagenase type IV
T16539 36552-36556 Protein denotes IRF7
T16538 36546-36550 Protein denotes IRF3
T16537 36552-36556 Protein denotes IRF7
T16536 36546-36550 Protein denotes IRF3
T16106 35951-35961 Gene_expression denotes expression
T16105 35946-35949 Protein denotes CD8
T16104 35937-35940 Protein denotes CD3
T16103 35876-35879 Protein denotes CD8
T16102 35482-35485 Protein denotes CD8
T16101 35471-35481 Gene_expression denotes expressing
T16100 35457-35460 Protein denotes GrB
T16099 35445-35455 Protein denotes Granzyme B
T16098 35432-35435 Protein denotes CD8
T16097 35397-35400 Protein denotes GrB
T16096 35946-35949 Protein denotes CD8
T16095 35937-35940 Protein denotes CD3
T16094 35876-35879 Protein denotes CD8
T16093 35482-35485 Protein denotes CD8
T16092 35457-35460 Protein denotes GrB
T16091 35445-35455 Protein denotes Granzyme B
T16090 35432-35435 Protein denotes CD8
T16089 35397-35400 Protein denotes GrB
T11693 31917-31927 Negative_regulation denotes inhibitors
T11692 30564-30574 Negative_regulation denotes deficiency
T11691 30465-30470 Protein denotes RIG-I
T11690 30410-30420 Gene_expression denotes expression
T11689 30172-30177 Protein denotes IRF-3
T11688 30143-30148 Protein denotes RIG-I
T11687 30134-30142 Regulation denotes regulate
T11686 30055-30059 Protein denotes CYLD
T11685 29858-29868 Positive_regulation denotes activation
T11684 29853-29857 Protein denotes IRF3
T11683 29718-29728 Negative_regulation denotes deficiency
T11682 29643-29647 Protein denotes IKKε
T11681 29634-29638 Protein denotes TBK1
T11680 29616-29630 Binding denotes ubiquitination
T11679 29527-29532 Protein denotes RIG-I
T11678 29449-29453 Protein denotes IRF3
T11677 29413-29417 Protein denotes IKKε
T11676 29404-29408 Protein denotes TBK1
T11675 29368-29377 Regulation denotes affecting
T11674 29312-29319 Negative_regulation denotes disrupt
T11673 29300-29305 Protein denotes ABIN1
T11672 29271-29278 Binding denotes binding
T11671 29089-29093 Protein denotes IRF3
T11670 28841-28851 Positive_regulation denotes activation
T11669 28836-28840 Protein denotes IRF3
T11668 28795-28799 Protein denotes IFNβ
T11667 28784-28789 Protein denotes MIP-2
T11666 28780-28782 Protein denotes KC
T11665 28774-28778 Protein denotes IL-6
T11664 28769-28772 Protein denotes TNF
T11663 28647-28652 Protein denotes RIG-I
T11662 28448-28453 Protein denotes RIG-I
T11661 28392-28397 Protein denotes RIG-I
T11660 28366-28376 Positive_regulation denotes activation
T11659 28361-28365 Protein denotes IRF3
T11658 28342-28350 Positive_regulation denotes enhanced
T11657 28319-28328 Negative_regulation denotes deficient
T11656 28060-28070 Negative_regulation denotes deficiency
T11655 27380-27389 Negative_regulation denotes deficient
T11654 27337-27347 Gene_expression denotes production
T11653 27331-27336 Protein denotes MCP-1
T11652 27207-27214 Negative_regulation denotes absence
T11651 27191-27199 Regulation denotes affected
T11650 27169-27174 Protein denotes MCP-1
T11649 26750-26755 Protein denotes IL-1β
T11648 26742-26745 Protein denotes TNF
T11647 26736-26740 Protein denotes IL-6
T11646 26684-26689 Protein denotes MIP-2
T11645 26677-26679 Protein denotes KC
T11644 25474-25484 Gene_expression denotes expression
T11643 30465-30470 Protein denotes RIG-I
T11642 30172-30177 Protein denotes IRF-3
T11641 30143-30148 Protein denotes RIG-I
T11640 30055-30059 Protein denotes CYLD
T11639 29853-29857 Protein denotes IRF3
T11638 29643-29647 Protein denotes IKKε
T11637 29634-29638 Protein denotes TBK1
T11636 29527-29532 Protein denotes RIG-I
T11635 29449-29453 Protein denotes IRF3
T11634 29413-29417 Protein denotes IKKε
T11633 29404-29408 Protein denotes TBK1
T11632 29300-29305 Protein denotes ABIN1
T11631 29089-29093 Protein denotes IRF3
T11630 28836-28840 Protein denotes IRF3
T11629 28795-28799 Protein denotes IFNβ
T11628 28784-28789 Protein denotes MIP-2
T11627 28780-28782 Protein denotes KC
T11626 28774-28778 Protein denotes IL-6
T11625 28769-28772 Protein denotes TNF
T11624 28647-28652 Protein denotes RIG-I
T11623 28448-28453 Protein denotes RIG-I
T11622 28392-28397 Protein denotes RIG-I
T11621 28361-28365 Protein denotes IRF3
T11620 27331-27336 Protein denotes MCP-1
T11619 27169-27174 Protein denotes MCP-1
T11618 26750-26755 Protein denotes IL-1β
T11617 26742-26745 Protein denotes TNF
T11616 26736-26740 Protein denotes IL-6
T11615 26684-26689 Protein denotes MIP-2
T11614 26677-26679 Protein denotes KC
T8708 24478-24488 Negative_regulation denotes deficiency
T8707 24173-24182 Positive_regulation denotes increased
T8706 24154-24164 Gene_expression denotes production
T8705 24148-24153 Protein denotes MCP-1
T8704 24043-24052 Positive_regulation denotes increased
T8703 23987-23997 Binding denotes associated
T8702 23964-23969 Protein denotes IL-1β
T8701 23956-23959 Protein denotes TNF
T8700 23950-23954 Protein denotes IL-6
T8699 23689-23699 Gene_expression denotes production
T8698 23683-23688 Protein denotes MIP-2
T8697 23676-23678 Protein denotes KC
T8696 22553-22563 Gene_expression denotes expression
T8695 22537-22545 Regulation denotes affected
T8694 22234-22238 Negative_regulation denotes loss
T8693 22088-22095 Negative_regulation denotes absence
T8692 22073-22080 Regulation denotes altered
T8691 22033-22043 Gene_expression denotes expression
T8690 21991-21994 Protein denotes GrB
T8689 21689-21699 Gene_expression denotes expressing
T8688 21675-21678 Protein denotes GrB
T8687 21663-21673 Protein denotes Granzyme B
T8686 21559-21569 Gene_expression denotes expression
T8685 21291-21299 Positive_regulation denotes elevated
T8684 21267-21272 Protein denotes F4/80
T8683 21168-21173 Protein denotes MCP-1
T8682 21154-21164 Gene_expression denotes expression
T8681 20759-20764 Protein denotes F4/80
T8680 20680-20685 Protein denotes MIP-2
T8679 20673-20675 Protein denotes KC
T8678 20507-20512 Protein denotes MCP-1
T8677 20457-20462 Protein denotes MIP-2
T8676 20427-20431 Protein denotes IL-8
T8675 20396-20398 Protein denotes KC
T8674 20337-20347 Gene_expression denotes production
T8673 20323-20328 Protein denotes MCP-1
T8672 20311-20319 Positive_regulation denotes increase
T8671 20069-20073 Protein denotes IL-6
T8670 20040-20045 Protein denotes MIP-2
T8669 20033-20035 Protein denotes KC
T8668 19807-19817 Negative_regulation denotes deficiency
T8667 18785-18789 Negative_regulation denotes loss
T8666 17721-17731 Gene_expression denotes expression
T8665 17709-17713 Regulation denotes role
T8664 17628-17638 Negative_regulation denotes deficiency
T8663 24148-24153 Protein denotes MCP-1
T8662 23964-23969 Protein denotes IL-1β
T8661 23956-23959 Protein denotes TNF
T8660 23950-23954 Protein denotes IL-6
T8659 23683-23688 Protein denotes MIP-2
T8658 23676-23678 Protein denotes KC
T8657 21991-21994 Protein denotes GrB
T8656 21675-21678 Protein denotes GrB
T8655 21663-21673 Protein denotes Granzyme B
T8654 21267-21272 Protein denotes F4/80
T8653 21168-21173 Protein denotes MCP-1
T8652 20759-20764 Protein denotes F4/80
T8651 20680-20685 Protein denotes MIP-2
T8650 20673-20675 Protein denotes KC
T8649 20507-20512 Protein denotes MCP-1
T8648 20457-20462 Protein denotes MIP-2
T8647 20427-20431 Protein denotes IL-8
T8646 20396-20398 Protein denotes KC
T8645 20323-20328 Protein denotes MCP-1
T8644 20069-20073 Protein denotes IL-6
T8643 20040-20045 Protein denotes MIP-2
T8642 20033-20035 Protein denotes KC
T7695 17611-17621 Positive_regulation denotes activation
T7694 17606-17610 Protein denotes IRF3
T7693 17582-17587 Protein denotes RIG-I
T7692 17299-17306 Negative_regulation denotes lacking
T7691 17245-17250 Protein denotes cxcl1
T7690 17241-17243 Protein denotes KC
T7689 17231-17235 Protein denotes ccl2
T7688 17224-17229 Protein denotes MCP-1
T7687 17199-17204 Protein denotes IFNα4
T7686 17190-17194 Protein denotes IFNβ
T7685 17170-17173 Protein denotes TNF
T7684 17161-17165 Protein denotes IL-6
T7683 17118-17127 Gene_expression denotes secretion
T7682 17103-17113 Gene_expression denotes Expression
T7681 15814-15818 Protein denotes IFNβ
T7680 15806-15809 Protein denotes TNF
T7679 15627-15631 Protein denotes IFNβ
T7678 15618-15622 Protein denotes IL-6
T7677 15604-15614 Gene_expression denotes expression
T7676 15595-15603 Positive_regulation denotes enhanced
T7675 15511-15520 Negative_regulation denotes deficient
T7674 15391-15400 Negative_regulation denotes deficient
T7673 17606-17610 Protein denotes IRF3
T7672 17582-17587 Protein denotes RIG-I
T7671 17245-17250 Protein denotes cxcl1
T7670 17241-17243 Protein denotes KC
T7669 17231-17235 Protein denotes ccl2
T7668 17224-17229 Protein denotes MCP-1
T7667 17199-17204 Protein denotes IFNα4
T7666 17190-17194 Protein denotes IFNβ
T7665 17170-17173 Protein denotes TNF
T7664 17161-17165 Protein denotes IL-6
T7663 15814-15818 Protein denotes IFNβ
T7662 15806-15809 Protein denotes TNF
T7661 15627-15631 Protein denotes IFNβ
T7660 15618-15622 Protein denotes IL-6
T4722 15168-15172 Protein denotes IRF3
T4721 15144-15149 Protein denotes RIG-I
T4720 14950-14954 Protein denotes IFNβ
T4719 14942-14945 Protein denotes TNF
T4718 14936-14940 Protein denotes IL-6
T4717 14915-14924 Positive_regulation denotes increased
T4716 14865-14869 Protein denotes IRF3
T4715 14809-14813 Protein denotes IFNβ
T4714 14795-14805 Gene_expression denotes expression
T4713 14783-14790 Regulation denotes control
T4712 14778-14782 Protein denotes IRF3
T4711 14759-14762 Protein denotes TNF
T4710 14750-14754 Protein denotes IL-6
T4709 14736-14746 Gene_expression denotes expression
T4708 14723-14731 Regulation denotes controls
T4707 14661-14670 Negative_regulation denotes deficient
T4706 14595-14608 Localization denotes translocation
T4705 14587-14594 Entity denotes nuclear
T4704 14582-14586 Protein denotes IRF3
T4703 14577-14580 Protein denotes p65
T4702 14455-14470 Phosphorylation denotes phosphorylation
T4701 14450-14454 Protein denotes IRF3
T4700 14419-14433 Phosphorylation denotes phosphorylated
T4699 14350-14357 Entity denotes nucleus
T4698 14329-14342 Localization denotes translocation
T4697 14275-14279 Protein denotes IKKε
T4696 14266-14270 Protein denotes TBK1
T4695 14177-14192 Phosphorylation denotes phosphorylation
T4694 14162-14171 Positive_regulation denotes activated
T4693 14142-14146 Protein denotes IRF3
T4692 14008-14016 Positive_regulation denotes enhanced
T4691 13986-13989 Protein denotes p65
T4690 13965-13978 Localization denotes translocation
T4689 13957-13964 Entity denotes nuclear
T4688 13926-13930 Protein denotes IκBα
T4687 13911-13922 Protein_catabolism denotes degradation
T4686 13901-13910 Positive_regulation denotes sustained
T4685 13881-13896 Phosphorylation denotes phosphorylation
T4684 13871-13880 Positive_regulation denotes increased
T4683 13806-13815 Negative_regulation denotes deficient
T4682 13527-13537 Gene_expression denotes expression
T4681 13521-13526 Positive_regulation denotes rapid
T4680 13509-13516 Positive_regulation denotes induced
T4679 13416-13420 Protein denotes IRF3
T4678 13391-13395 Protein denotes TLR3
T4677 13306-13310 Protein denotes MDA5
T4676 13288-13293 Protein denotes RIG-I
T4675 13270-13274 Binding denotes bind
T4674 13100-13105 Protein denotes RIG-I
T4673 12931-12938 Regulation denotes control
T4672 12898-12908 Gene_expression denotes expressing
T4671 12611-12620 Negative_regulation denotes deficient
T4670 12505-12510 Protein denotes RIG-I
T4669 11070-11080 Positive_regulation denotes activation
T4668 11068-11069 Protein denotes 7
T4667 11063-11067 Protein denotes IRF3
T4666 11039-11044 Protein denotes RIG-I
T4665 10939-10943 Protein denotes IRF7
T4664 10925-10930 Protein denotes RIG-I
T4663 10894-10904 Positive_regulation denotes activation
T4662 10889-10893 Protein denotes IRF3
T4661 10837-10841 Protein denotes IRF7
T4660 10666-10679 Gene_expression denotes co-expression
T4659 10661-10665 Protein denotes IRF7
T4658 10632-10642 Gene_expression denotes expression
T4657 10587-10597 Protein denotes luciferase
T4656 10567-10571 Protein denotes IRF7
T4655 10490-10500 Gene_expression denotes expression
T4654 10485-10489 Protein denotes IRF7
T4653 10423-10427 Protein denotes IRF7
T4652 10406-10412 Regulation denotes effect
T4651 10366-10376 Positive_regulation denotes activation
T4650 10361-10365 Protein denotes IRF3
T4649 10353-10360 Positive_regulation denotes induced
T4648 10298-10302 Protein denotes IRF7
T4647 10261-10270 Gene_expression denotes expressed
T4646 10239-10243 Protein denotes IRF7
T4645 10233-10237 Protein denotes IRF3
T4644 10209-10213 Protein denotes IRF7
T4643 10104-10109 Protein denotes RIG-I
T4642 10035-10040 Protein denotes RIG-I
T4641 9997-10031 Protein denotes truncated constitutive active form
T4640 9968-9975 Positive_regulation denotes induced
T4639 9932-9942 Protein denotes luciferase
T4638 9922-9931 Regulation denotes dependent
T4637 9917-9921 Protein denotes IRF3
T4636 9865-9879 Positive_regulation denotes overexpression
T4635 9808-9813 Protein denotes RIG-I
T4634 9792-9802 Positive_regulation denotes activation
T4633 9787-9791 Protein denotes IRF3
T4632 9554-9558 Protein denotes IRF7
T4631 9545-9549 Protein denotes IRF3
T4630 9524-9534 Positive_regulation denotes activation
T4629 9512-9519 Positive_regulation denotes induces
T4628 9496-9501 Protein denotes RIG-I
T4627 9485-9495 Positive_regulation denotes activation
T4626 9480-9484 Protein denotes IRF3
T4625 9456-9461 Protein denotes RIG-I
T4624 15168-15172 Protein denotes IRF3
T4623 15144-15149 Protein denotes RIG-I
T4622 14950-14954 Protein denotes IFNβ
T4621 14942-14945 Protein denotes TNF
T4620 14936-14940 Protein denotes IL-6
T4619 14865-14869 Protein denotes IRF3
T4618 14809-14813 Protein denotes IFNβ
T4617 14778-14782 Protein denotes IRF3
T4616 14759-14762 Protein denotes TNF
T4615 14750-14754 Protein denotes IL-6
T4614 14582-14586 Protein denotes IRF3
T4613 14577-14580 Protein denotes p65
T4612 14450-14454 Protein denotes IRF3
T4611 14275-14279 Protein denotes IKKε
T4610 14266-14270 Protein denotes TBK1
T4609 14142-14146 Protein denotes IRF3
T4608 13986-13989 Protein denotes p65
T4607 13926-13930 Protein denotes IκBα
T4606 13416-13420 Protein denotes IRF3
T4605 13391-13395 Protein denotes TLR3
T4604 13306-13310 Protein denotes MDA5
T4603 13288-13293 Protein denotes RIG-I
T4602 13100-13105 Protein denotes RIG-I
T4601 12505-12510 Protein denotes RIG-I
T4600 11068-11069 Protein denotes 7
T4599 11063-11067 Protein denotes IRF3
T4598 11039-11044 Protein denotes RIG-I
T4597 10939-10943 Protein denotes IRF7
T4596 10925-10930 Protein denotes RIG-I
T4595 10889-10893 Protein denotes IRF3
T4594 10837-10841 Protein denotes IRF7
T4593 10661-10665 Protein denotes IRF7
T4592 10587-10597 Protein denotes luciferase
T4591 10567-10571 Protein denotes IRF7
T4590 10485-10489 Protein denotes IRF7
T4589 10423-10427 Protein denotes IRF7
T4588 10361-10365 Protein denotes IRF3
T4587 10298-10302 Protein denotes IRF7
T4586 10239-10243 Protein denotes IRF7
T4585 10233-10237 Protein denotes IRF3
T4584 10209-10213 Protein denotes IRF7
T4583 10104-10109 Protein denotes RIG-I
T4582 10035-10040 Protein denotes RIG-I
T4581 9997-10031 Protein denotes truncated constitutive active form
T4580 9932-9942 Protein denotes luciferase
T4579 9917-9921 Protein denotes IRF3
T4578 9808-9813 Protein denotes RIG-I
T4577 9787-9791 Protein denotes IRF3
T4576 9554-9558 Protein denotes IRF7
T4575 9545-9549 Protein denotes IRF3
T4574 9496-9501 Protein denotes RIG-I
T4573 9480-9484 Protein denotes IRF3
T4572 9456-9461 Protein denotes RIG-I
T908 8527-8532 Protein denotes IRF-3
T907 8496-8503 Positive_regulation denotes induced
T906 8491-8495 Protein denotes TLR3
T905 8480-8485 Protein denotes RIG-I
T904 8471-8479 Regulation denotes regulate
T903 7622-7631 Negative_regulation denotes deficient
T902 7531-7536 Protein denotes IL-1R
T901 7516-7520 Protein denotes TLR4
T900 7490-7504 Protein denotes TNF receptor I
T899 7062-7067 Protein denotes RBCK1
T898 7046-7052 Protein denotes TRIM21
T897 7035-7039 Protein denotes RAUL
T896 6993-6997 Protein denotes IRF7
T895 6984-6988 Protein denotes IRF3
T894 6852-6863 Protein_catabolism denotes degradation
T893 6822-6827 Protein denotes TRAF3
T892 6813-6817 Protein denotes MAVS
T891 6782-6789 Protein denotes TRIAD3A
T890 6768-6772 Protein denotes AIP4
T889 6602-6605 Protein denotes RLR
T888 6593-6601 Regulation denotes regulate
T887 6530-6534 Protein denotes CYLD
T886 6519-6523 Protein denotes DUBA
T885 6440-6445 Protein denotes RIG-I
T884 6424-6434 Positive_regulation denotes activation
T883 6419-6423 Protein denotes IRF3
T882 6377-6382 Protein denotes TRAF3
T881 6356-6361 Protein denotes TRAF6
T880 6280-6285 Protein denotes RIG-I
T879 6225-6231 Protein denotes Riplet
T878 6209-6215 Protein denotes TRIM25
T877 6122-6127 Protein denotes RIG-I
T876 6011-6015 Protein denotes MAVS
T875 5944-5975 Entity denotes C-terminal transmembrane domain
T874 5872-5884 Localization denotes translocates
T873 5828-5834 Protein denotes Cardif
T872 5822-5826 Protein denotes VISA
T871 5815-5820 Protein denotes IPS-1
T870 5797-5801 Protein denotes MAVS
T869 5759-5768 Binding denotes associate
T868 5753-5758 Protein denotes RIG-I
T867 5724-5731 Binding denotes binding
T866 5581-5586 Protein denotes RIG-I
T865 5335-5344 Negative_regulation denotes deficient
T864 5330-5334 Protein denotes TLR3
T863 5265-5274 Negative_regulation denotes deficient
T862 5259-5264 Protein denotes RIG-I
T861 5213-5218 Protein denotes RIG-I
T860 5003-5008 Protein denotes RIG-I
T859 4994-4998 Protein denotes TLR3
T858 4139-4148 Gene_expression denotes producing
T857 4054-4059 Protein denotes IFI16
T856 4031-4035 Protein denotes AIM2
T855 3982-3985 Protein denotes DAI
T854 3976-3980 Protein denotes TLR9
T853 3880-3884 Protein denotes MDA5
T852 3873-3878 Protein denotes RIG-I
T851 3867-3871 Protein denotes TLR3
T850 3837-3841 Protein denotes Nod2
T849 3831-3835 Protein denotes TLR8
T848 3825-3829 Protein denotes TLR7
T847 3461-3465 Protein denotes IRF7
T846 3452-3456 Protein denotes IRF3
T845 3329-3334 Protein denotes IFN-β
T844 3318-3323 Protein denotes IFN-α
T843 3304-3316 Protein denotes interferon-α
T842 3274-3278 Protein denotes IL-1
T841 3265-3269 Protein denotes IL-6
T840 3260-3263 Protein denotes TNF
T839 8527-8532 Protein denotes IRF-3
T838 8491-8495 Protein denotes TLR3
T837 8480-8485 Protein denotes RIG-I
T836 7531-7536 Protein denotes IL-1R
T835 7516-7520 Protein denotes TLR4
T834 7490-7504 Protein denotes TNF receptor I
T833 7062-7067 Protein denotes RBCK1
T832 7046-7052 Protein denotes TRIM21
T831 7035-7039 Protein denotes RAUL
T830 6993-6997 Protein denotes IRF7
T829 6984-6988 Protein denotes IRF3
T828 6822-6827 Protein denotes TRAF3
T827 6813-6817 Protein denotes MAVS
T826 6782-6789 Protein denotes TRIAD3A
T811 5822-5826 Protein denotes VISA
T810 5815-5820 Protein denotes IPS-1
T809 5797-5801 Protein denotes MAVS
T808 5753-5758 Protein denotes RIG-I
T807 5581-5586 Protein denotes RIG-I
T806 5330-5334 Protein denotes TLR3
T805 5259-5264 Protein denotes RIG-I
T804 5213-5218 Protein denotes RIG-I
T803 5003-5008 Protein denotes RIG-I
T802 4994-4998 Protein denotes TLR3
T801 4054-4059 Protein denotes IFI16
T800 4031-4035 Protein denotes AIM2
T799 3982-3985 Protein denotes DAI
T798 3976-3980 Protein denotes TLR9
T797 3880-3884 Protein denotes MDA5
T796 3873-3878 Protein denotes RIG-I
T795 3867-3871 Protein denotes TLR3
T794 3837-3841 Protein denotes Nod2
T793 3831-3835 Protein denotes TLR8
T792 3825-3829 Protein denotes TLR7
T791 3461-3465 Protein denotes IRF7
T790 3452-3456 Protein denotes IRF3
T789 3329-3334 Protein denotes IFN-β
T788 3318-3323 Protein denotes IFN-α
T787 3304-3316 Protein denotes interferon-α
T786 3274-3278 Protein denotes IL-1
T785 3265-3269 Protein denotes IL-6
T784 3260-3263 Protein denotes TNF
T825 6768-6772 Protein denotes AIP4
T824 6602-6605 Protein denotes RLR
T823 6530-6534 Protein denotes CYLD
T822 6519-6523 Protein denotes DUBA
T821 6440-6445 Protein denotes RIG-I
T820 6419-6423 Protein denotes IRF3
T819 6377-6382 Protein denotes TRAF3
T818 6356-6361 Protein denotes TRAF6
T817 6280-6285 Protein denotes RIG-I
T816 6225-6231 Protein denotes Riplet
T815 6209-6215 Protein denotes TRIM25
T814 6122-6127 Protein denotes RIG-I
T813 6011-6015 Protein denotes MAVS
T812 5828-5834 Protein denotes Cardif
T22 1512-1522 Negative_regulation denotes inhibition
T21 992-996 Protein denotes IRF3
T20 463-468 Protein denotes RIG-I
T19 433-462 Protein denotes pathogen recognition receptor
T16 992-996 Protein denotes IRF3
T15 463-468 Protein denotes RIG-I
T14 433-462 Protein denotes pathogen recognition receptor
R3172 T4633 T4634 themeOf IRF3,activation
R3173 T4635 T4634 causeOf RIG-I,activation
R3174 T4637 T4638 causeOf IRF3,dependent
R3175 T4638 T4641 themeOf dependent,truncated constitutive active form
R3176 T4639 T4641 themeOf luciferase,truncated constitutive active form
R3177 T4641 T4640 causeOf truncated constitutive active form,induced
R3178 T4642 T4640 causeOf RIG-I,induced
R3179 T4642 T4641 themeOf RIG-I,truncated constitutive active form
R3180 T4645 T4647 themeOf IRF3,expressed
R3181 T4646 T4647 themeOf IRF7,expressed
R3182 T4650 T4651 themeOf IRF3,activation
R3183 T4651 T4649 themeOf activation,induced
R3184 T4654 T4655 themeOf IRF7,expression
R3185 T4659 T4660 themeOf IRF7,co-expression
R3186 T4662 T4663 themeOf IRF3,activation
R3187 T4667 T4669 themeOf IRF3,activation
R3188 T4668 T4669 themeOf 7,activation
R3189 T4674 T4675 themeOf RIG-I,bind
R3190 T4676 T4675 themeOf RIG-I,bind
R3191 T4677 T4675 themeOf MDA5,bind
R3192 T4681 T4680 themeOf rapid,induced
R3193 T4682 T4680 themeOf expression,induced
R3194 T4682 T4681 themeOf expression,rapid
R3195 T4683 T4684 causeOf deficient,increased
R3196 T4683 T4686 causeOf deficient,sustained
R3197 T4685 T4684 themeOf phosphorylation,increased
R3198 T4685 T4686 causeOf phosphorylation,sustained
R3199 T4687 T4686 themeOf degradation,sustained
R3200 T4688 T4687 themeOf IκBα,degradation
R3201 T4688 T4685 themeOf IκBα,phosphorylation
R3202 T4689 T4690 locationOf nuclear,translocation
R3203 T4690 T4692 themeOf translocation,enhanced
R3204 T4691 T4690 themeOf p65,translocation
R3205 T4693 T4698 themeOf IRF3,translocation
R3206 T4693 T4694 themeOf IRF3,activated
R3207 T4697 T4698 themeOf IKKε,translocation
R3208 T4699 T4698 locationOf nucleus,translocation
R3209 T4701 T4702 themeOf IRF3,phosphorylation
R3210 T4703 T4706 themeOf p65,translocation
R3211 T4704 T4706 themeOf IRF3,translocation
R3212 T4705 T4706 locationOf nuclear,translocation
R3213 T4709 T4708 themeOf expression,controls
R3214 T4710 T4709 themeOf IL-6,expression
R3215 T4711 T4709 themeOf TNF,expression
R3216 T4712 T4713 causeOf IRF3,control
R3217 T4712 T4709 themeOf IRF3,expression
R3218 T4714 T4713 themeOf expression,control
R3219 T4715 T4714 themeOf IFNβ,expression
R3220 T4718 T4717 themeOf IL-6,increased
R3221 T4719 T4717 themeOf TNF,increased
R3222 T4720 T4717 themeOf IFNβ,increased
R5394 T7677 T7676 themeOf expression,enhanced
R5395 T7678 T7677 themeOf IL-6,expression
R5396 T7679 T7677 themeOf IFNβ,expression
R5397 T7684 T7683 themeOf IL-6,secretion
R5398 T7684 T7682 themeOf IL-6,Expression
R5399 T7685 T7682 themeOf TNF,Expression
R5400 T7685 T7683 themeOf TNF,secretion
R5401 T7686 T7682 themeOf IFNβ,Expression
R5402 T7686 T7683 themeOf IFNβ,secretion
R5403 T7687 T7682 themeOf IFNα4,Expression
R5404 T7687 T7683 themeOf IFNα4,secretion
R5405 T7688 T7683 themeOf MCP-1,secretion
R5406 T7688 T7682 themeOf MCP-1,Expression
R5407 T7689 T7688 equivalentTo ccl2,MCP-1
R5408 T7690 T7682 themeOf KC,Expression
R5409 T7690 T7683 themeOf KC,secretion
R5410 T7691 T7688 equivalentTo cxcl1,MCP-1
R5411 T7691 T7690 equivalentTo cxcl1,KC
R5412 T7694 T7695 themeOf IRF3,activation
R6102 T8666 T8665 themeOf expression,role
R6103 T8673 T8674 themeOf MCP-1,production
R6104 T8674 T8672 themeOf production,increase
R6105 T8683 T8682 themeOf MCP-1,expression
R6106 T8687 T8689 themeOf Granzyme B,expressing
R6107 T8688 T8687 equivalentTo GrB,Granzyme B
R6108 T8690 T8691 themeOf GrB,expression
R6109 T8691 T8692 themeOf expression,altered
R6110 T8693 T8692 causeOf absence,altered
R6111 T8697 T8699 themeOf KC,production
R6112 T8698 T8699 themeOf MIP-2,production
R6113 T8700 T8703 themeOf IL-6,associated
R6114 T8701 T8703 themeOf TNF,associated
R6115 T8702 T8703 themeOf IL-1β,associated
R6116 T8703 T8704 themeOf associated,increased
R6117 T8705 T8706 themeOf MCP-1,production
R6118 T8706 T8707 themeOf production,increased
R8470 T11650 T11651 themeOf MCP-1,affected
R8471 T11653 T11654 themeOf MCP-1,production
R8472 T11657 T11658 causeOf deficient,enhanced
R8473 T11659 T11660 themeOf IRF3,activation
R8474 T11660 T11658 themeOf activation,enhanced
R8475 T11669 T11670 themeOf IRF3,activation
R8476 T11673 T11672 themeOf ABIN1,binding
R8477 T11681 T11680 themeOf TBK1,ubiquitination
R8478 T11682 T11680 themeOf IKKε,ubiquitination
R8479 T11684 T11685 themeOf IRF3,activation
R8480 T11689 T11687 themeOf IRF-3,regulate
R14507 T19339 T19340 themeOf IRF3,expressed
R15139 T20269 T20271 themeOf IL-6,mRNA expression
R15140 T20270 T20271 themeOf IFNβ,mRNA expression
R15141 T20274 T20276 themeOf IL-6,mRNA expression
R15142 T20275 T20276 themeOf IFNβ,mRNA expression
R531 T844 T843 equivalentTo IFN-α,interferon-α
R532 T862 T863 themeOf RIG-I,deficient
R533 T864 T865 themeOf TLR3,deficient
R534 T868 T869 themeOf RIG-I,associate
R535 T870 T874 themeOf MAVS,translocates
R536 T871 T874 themeOf IPS-1,translocates
R537 T872 T874 themeOf VISA,translocates
R538 T873 T874 themeOf Cardif,translocates
R539 T875 T870 partOf C-terminal transmembrane domain,MAVS
R540 T875 T867 themeOf C-terminal transmembrane domain,binding
R541 T875 T874 themeOf C-terminal transmembrane domain,translocates
R542 T875 T868 partOf C-terminal transmembrane domain,RIG-I
R543 T875 T871 partOf C-terminal transmembrane domain,IPS-1
R544 T875 T873 partOf C-terminal transmembrane domain,Cardif
R545 T881 T884 themeOf TRAF6,activation
R546 T882 T884 themeOf TRAF3,activation
R547 T883 T884 themeOf IRF3,activation
R548 T885 T884 causeOf RIG-I,activation
R549 T905 T907 causeOf RIG-I,induced
R550 T906 T907 causeOf TLR3,induced
R551 T907 T904 themeOf induced,regulate
R3167 T4626 T4627 themeOf IRF3,activation
R3168 T4628 T4629 causeOf RIG-I,induces
R3169 T4630 T4629 themeOf activation,induces
R3170 T4631 T4630 themeOf IRF3,activation
R3171 T4632 T4630 themeOf IRF7,activation
R12121 T16099 T16101 themeOf Granzyme B,expressing
R12122 T16100 T16099 equivalentTo GrB,Granzyme B
R12123 T16104 T16106 themeOf CD3,expression
R12124 T16105 T16106 themeOf CD8,expression
R14499 T19325 T19326 themeOf luciferase,expressing
R14500 T19327 T19326 themeOf IRF7,expressing
R14501 T19328 T19330 themeOf IκBα,degradation
R14502 T19328 T19329 themeOf IκBα,phosphorylation
R14503 T19331 T19332 themeOf IRF3,phosphorylation
R14504 T19334 T19335 locationOf Nuclear,translocation
R14505 T19337 T19335 themeOf IRF3,translocation
R14506 T19338 T19340 themeOf p65,expressed

2_test

Id Subject Object Predicate Lexical cue
22396652-20404851-98461805 3467-3468 20404851 denotes 1
22396652-20303872-98461806 3472-3473 20303872 denotes 2
22396652-19120475-98461807 3652-3653 19120475 denotes 3
22396652-17618271-98461808 3987-3988 17618271 denotes 4
22396652-19158679-98461809 4037-4038 19158679 denotes 5
22396652-19158676-98461810 4042-4043 19158676 denotes 6
22396652-19158675-98461811 4047-4048 19158675 denotes 7
22396652-20890285-98461812 4061-4062 20890285 denotes 8
22396652-16039576-98461813 4362-4363 16039576 denotes 9
22396652-20144762-98461814 5059-5061 20144762 denotes 10
22396652-20805493-98461815 5064-5066 20805493 denotes 12
22396652-17942531-98461816 5239-5241 17942531 denotes 13
22396652-16625202-98461817 5311-5313 16625202 denotes 14
22396652-16714379-98461818 5317-5319 16714379 denotes 15
22396652-16789835-98461819 5396-5398 16789835 denotes 16
22396652-16153868-98461820 5977-5979 16153868 denotes 17
22396652-16127453-98461821 5982-5984 16127453 denotes 20
22396652-17392790-98461822 6217-6219 17392790 denotes 22
22396652-19484123-98461823 6233-6235 19484123 denotes 23
22396652-21147464-98461824 6239-6241 21147464 denotes 24
22396652-16306936-98461825 6363-6365 16306936 denotes 25
22396652-16306937-98461826 6369-6371 16306937 denotes 26
22396652-19479062-98461827 6384-6386 19479062 denotes 27
22396652-17991829-98461828 6525-6527 17991829 denotes 28
22396652-18467330-98461829 6536-6538 18467330 denotes 29
22396652-18636086-98461830 6542-6544 18636086 denotes 30
22396652-19996094-98461831 6559-6561 19996094 denotes 31
22396652-19881509-98461832 6774-6776 19881509 denotes 32
22396652-19893624-98461833 6791-6793 19893624 denotes 33
22396652-21167755-98461834 7041-7043 21167755 denotes 34
22396652-19635865-98461835 7054-7056 19635865 denotes 35
22396652-18711448-98461836 7069-7071 18711448 denotes 36
22396652-11009421-98461837 7506-7508 11009421 denotes 37
22396652-22099304-98461838 7511-7513 22099304 denotes 39
22396652-15334086-98461839 7522-7524 15334086 denotes 40
22396652-20185725-98461840 7538-7540 20185725 denotes 41
22396652-11009421-98461841 7712-7714 11009421 denotes 37
22396652-22019834-98461842 7848-7850 22019834 denotes 42
22396652-21841782-98461843 7853-7855 21841782 denotes 48
22396652-19643665-98461844 8160-8162 19643665 denotes 45
22396652-16765340-98461845 8534-8536 16765340 denotes 49
22396652-15661910-98461846 8539-8541 15661910 denotes 52
22396652-16306043-98461847 9827-9829 16306043 denotes 50
22396652-15661910-98461848 9832-9834 15661910 denotes 52
22396652-15208624-98461849 10042-10044 15208624 denotes 53
22396652-10893229-98461850 10378-10380 10893229 denotes 54
22396652-11070172-98461851 10384-10386 11070172 denotes 55
22396652-11009421-98461852 12735-12737 11009421 denotes 37
22396652-20530205-98461853 12852-12854 20530205 denotes 56
22396652-21841782-98461854 13078-13080 21841782 denotes 48
22396652-18591409-98461855 13312-13314 18591409 denotes 57
22396652-15210742-98461856 14281-14283 15210742 denotes 58
22396652-9566918-98461857 14359-14361 9566918 denotes 59
22396652-17277103-98461858 20641-20643 17277103 denotes 60
22396652-6206190-98461859 21522-21524 6206190 denotes 61
22396652-1552285-98461860 21528-21530 1552285 denotes 62
22396652-17579060-98461861 21534-21536 17579060 denotes 63
22396652-17213831-98461862 24033-24035 17213831 denotes 64
22396652-8426110-98461863 25791-25793 8426110 denotes 65
22396652-2526847-98461864 25797-25799 2526847 denotes 66
22396652-16282492-98461865 25967-25969 16282492 denotes 67
22396652-20504924-98461866 25973-25975 20504924 denotes 68
22396652-1753101-98461867 26135-26137 1753101 denotes 69
22396652-17723216-98461868 26191-26193 17723216 denotes 70
22396652-21423798-98461869 27158-27160 21423798 denotes 71
22396652-18671884-98461870 27164-27166 18671884 denotes 72
22396652-11748284-98461871 27370-27372 11748284 denotes 73
22396652-19064696-98461872 27558-27560 19064696 denotes 74
22396652-10854218-98461873 27563-27565 10854218 denotes 76
22396652-18250467-98461874 27679-27681 18250467 denotes 77
22396652-15240656-98461875 27753-27755 15240656 denotes 78
22396652-17213831-98461876 28012-28014 17213831 denotes 64
22396652-19864182-98461877 28018-28020 19864182 denotes 79
22396652-15240656-98461878 28297-28299 15240656 denotes 78
22396652-17942531-98461879 28537-28539 17942531 denotes 13
22396652-20599425-98461880 29188-29190 20599425 denotes 80
22396652-20304918-98461881 29455-29457 20304918 denotes 81
22396652-21885437-98461882 29461-29463 21885437 denotes 82
22396652-17991829-98461883 30050-30052 17991829 denotes 28
22396652-18467330-98461884 30061-30063 18467330 denotes 29
22396652-18636086-98461885 30067-30069 18636086 denotes 30
22396652-19996094-98461886 30081-30083 19996094 denotes 31
22396652-16765340-98461887 30095-30097 16765340 denotes 49
22396652-15661910-98461888 30100-30102 15661910 denotes 52
22396652-21431695-98461889 31694-31696 21431695 denotes 83
22396652-20530205-98461890 32721-32723 20530205 denotes 56
22396652-10621974-98461891 32773-32775 10621974 denotes 84
22396652-21841782-98461892 32936-32938 21841782 denotes 48
22396652-21187318-98461893 35601-35603 21187318 denotes 86

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T69 0-3 NN denotes A20
T70 4-5 -LRB- denotes (
T71 5-12 NN denotes Tnfaip3
T72 12-13 -RRB- denotes )
T73 14-24 NN denotes Deficiency
T74 25-27 IN denotes in
T75 28-35 NNP denotes Myeloid
T76 36-41 NNP denotes Cells
T77 42-50 NNP denotes Protects
T78 51-58 IN denotes against
T79 59-68 NNP denotes Influenza
T80 69-70 NNP denotes A
T81 71-76 NNP denotes Virus
T82 77-86 NNP denotes Infection
T1999 6542-6544 CD denotes 30
T21355 25217-25221 NN denotes flow
T21386 25372-25373 -COLON- denotes ;
T21389 25378-25382 CD denotes 0.01
T21388 25377-25378 SYM denotes <
T21387 25374-25377 NN denotes **p
T21385 25368-25372 CD denotes 0.05
T21384 25367-25368 SYM denotes <
T21383 25365-25367 NN denotes *p
T21382 25352-25364 NN denotes experiments.
T21381 25340-25351 JJ denotes independent
T21380 25338-25339 CD denotes 2
T21379 25335-25337 IN denotes of
T21378 25320-25334 JJ denotes representative
T21377 25316-25319 VB denotes are
T21376 25311-25315 NN denotes Data
T21375 25304-25309 NN denotes group
T21374 25300-25303 IN denotes per
T21373 25295-25299 NN denotes mice
T21372 25293-25294 CD denotes 5
T21371 25287-25292 JJ denotes least
T21370 25284-25286 IN denotes at
T21369 25281-25283 IN denotes of
T21368 25277-25280 NN denotes SEM
T21367 25273-25276 CC denotes +/−
T21366 25264-25272 NN denotes averages
T21365 25260-25263 VB denotes are
T21364 25252-25259 NN denotes Numbers
T21363 25249-25250 -RRB- denotes )
T21362 25248-25249 NN denotes D
T21361 25247-25248 -LRB- denotes (
T21360 25242-25246 NN denotes p.i.
T21359 25237-25241 NN denotes days
T21358 25235-25236 CD denotes 6
T21357 25232-25234 IN denotes at
T21356 25222-25231 NN denotes cytometry
T21354 25214-25216 IN denotes by
T21353 25205-25213 VB denotes analyzed
T21352 25200-25204 VB denotes were
T21351 25196-25199 NN denotes BAL
T21350 25193-25195 IN denotes in
T21349 25183-25192 NN denotes monocytes
T21348 25179-25182 CC denotes and
T21347 25167-25178 NN denotes neutrophils
T21346 25165-25166 -COMMA- denotes ,
T21345 25154-25165 NN denotes macrophages
T21344 25145-25153 JJ denotes alveolar
T21343 25142-25144 IN denotes of
T21342 25134-25141 NN denotes numbers
T21341 25125-25133 JJ denotes Absolute
T21340 25122-25123 -RRB- denotes )
T21339 25121-25122 NN denotes C
T21338 25120-25121 -LRB- denotes (
T21337 25109-25119 VB denotes determined
T21336 25104-25108 VB denotes were
T21335 25097-25103 NN denotes levels
T21334 25089-25096 NN denotes protein
T21333 25084-25088 NN denotes IFNα
T21332 25080-25083 CC denotes and
T21331 25075-25079 NN denotes IL-6
T21330 25073-25074 -COMMA- denotes ,
T21329 25068-25073 NN denotes MCP-1
T21328 25066-25067 -COMMA- denotes ,
T21327 25061-25066 NN denotes MIP-2
T21326 25059-25060 -COMMA- denotes ,
T21325 25057-25059 NN denotes KC
T21324 25053-25056 CC denotes and
T21323 25049-25052 NN denotes IAV
T21322 25044-25048 NN denotes dose
T21321 25037-25043 JJ denotes lethal
T21320 25035-25036 DT denotes a
T21319 25030-25034 IN denotes with
T21318 25020-25029 NN denotes infection
T21317 25010-25019 VB denotes following
T21316 25005-25009 NN denotes days
T21315 25003-25004 CD denotes 6
T21314 24998-25002 NN denotes mice
T21313 24987-24997 NN denotes A20myel-KO
T21312 24983-24986 CC denotes and
T21311 24981-24982 -RRB- denotes )
T21310 24971-24981 NN denotes A20myel-WT
T21309 24970-24971 -LRB- denotes (
T21308 24965-24969 NN denotes type
T21307 24960-24964 JJ denotes wild
T21306 24955-24959 IN denotes from
T21305 24945-24954 VB denotes collected
T21304 24941-24944 VB denotes was
T21303 24935-24940 NN denotes fluid
T21302 24931-24934 NN denotes BAL
T21301 24926-24929 NN denotes p.i
T21300 24921-24925 NN denotes days
T21299 24918-24920 CD denotes 15
T21298 24914-24917 CC denotes and
T21297 24911-24913 CD denotes 21
T21296 24898-24910 RB denotes respectively
T21295 24894-24897 IN denotes for
T21294 24884-24893 VB denotes monitored
T21293 24880-24883 VB denotes was
T21292 24878-24879 -RRB- denotes )
T21291 24877-24878 NN denotes B
T21290 24876-24877 -LRB- denotes (
T21289 24872-24875 NN denotes SEM
T21288 24868-24871 CC denotes +/−
T21287 24863-24867 NN denotes loss
T21286 24856-24862 NN denotes weight
T21285 24852-24855 CC denotes and
T21284 24850-24851 -RRB- denotes )
T21283 24849-24850 NN denotes A
T21282 24848-24849 -LRB- denotes (
T21281 24846-24847 -RRB- denotes )
T21280 24841-24846 CD denotes 0.001
T21279 24840-24841 SYM denotes <
T21278 24839-24840 NN denotes p
T21277 24838-24839 -LRB- denotes (
T21276 24829-24837 NN denotes survival
T21275 24825-24828 CC denotes and
T21274 24821-24824 NN denotes IAV
T21273 24818-24820 IN denotes of
T21272 24813-24817 NN denotes dose
T21271 24806-24812 JJ denotes lethal
T21270 24804-24805 DT denotes a
T21269 24799-24803 IN denotes with
T21268 24790-24798 VB denotes infected
T21267 24777-24789 RB denotes intranasally
T21266 24772-24776 VB denotes were
T21265 24767-24771 NN denotes mice
T21264 24765-24766 -RRB- denotes )
T21263 24759-24765 NN denotes n = 11
T21262 24758-24759 -LRB- denotes (
T21261 24747-24757 NN denotes A20myel-KO
T21260 24743-24746 CC denotes and
T21259 24741-24742 -RRB- denotes )
T21258 24735-24741 NN denotes n = 11
T21257 24734-24735 -LRB- denotes (
T21256 24723-24733 NN denotes A20myel-WT
T21255 24712-24721 NN denotes infection
T21254 24708-24711 NN denotes IAV
T21253 24701-24707 JJ denotes lethal
T21252 24693-24700 IN denotes against
T21251 24684-24692 VB denotes protects
T21250 24678-24683 NN denotes cells
T21249 24670-24677 JJ denotes myeloid
T21248 24667-24669 IN denotes in
T21247 24656-24666 NN denotes deficiency
T21246 24652-24655 NN denotes A20
T21393 25389-25394 CD denotes 0.001
T21392 25388-25389 SYM denotes <
T21391 25384-25388 NN denotes ***p
T21390 25382-25383 -COMMA- denotes ,
T20964 19784-19788 CD denotes 0.01
T20963 19783-19784 SYM denotes <
T20962 19780-19783 NN denotes **p
T20961 19778-19779 -COLON- denotes ;
T20960 19774-19778 CD denotes 0.05
T20959 19773-19774 SYM denotes <
T20958 19771-19773 NN denotes *p
T20957 19758-19770 NN denotes experiments.
T20956 19746-19757 JJ denotes independent
T20955 19744-19745 CD denotes 2
T20954 19741-19743 IN denotes of
T20953 19726-19740 JJ denotes representative
T20952 19722-19725 VB denotes are
T20951 19718-19721 CC denotes and
T20948 19703-19707 NN denotes mice
T20947 19701-19702 CD denotes 5
T20946 19695-19700 JJ denotes least
T20945 19692-19694 IN denotes at
T20944 19689-19691 IN denotes of
T20943 19685-19688 NN denotes SEM
T20942 19681-19684 CC denotes +/−
T20941 19672-19680 NN denotes averages
T20940 19668-19671 VB denotes are
T20939 19660-19667 NN denotes Numbers
T20938 19657-19658 -RRB- denotes )
T20937 19656-19657 NN denotes D
T20936 19655-19656 -LRB- denotes (
T20935 19650-19654 NN denotes p.i.
T20934 19645-19649 NN denotes days
T20933 19642-19644 CD denotes 10
T20932 19638-19641 CC denotes and
T20931 19636-19637 CD denotes 7
T20930 19634-19635 -COMMA- denotes ,
T20929 19633-19634 CD denotes 4
T20928 19630-19632 IN denotes at
T20927 19620-19629 NN denotes cytometry
T20926 19615-19619 NN denotes flow
T20925 19612-19614 IN denotes by
T20924 19603-19611 VB denotes analyzed
T20923 19598-19602 VB denotes were
T20922 19594-19597 NN denotes BAL
T20921 19591-19593 IN denotes in
T20920 19581-19590 NN denotes monocytes
T20919 19577-19580 CC denotes and
T20918 19565-19576 NN denotes neutrophils
T20917 19563-19564 -COMMA- denotes ,
T20916 19552-19563 NN denotes macrophages
T20915 19543-19551 JJ denotes alveolar
T20914 19534-19542 JJ denotes resident
T20913 19531-19533 IN denotes of
T20912 19523-19530 NN denotes numbers
T20911 19514-19522 JJ denotes Absolute
T20910 19511-19512 -RRB- denotes )
T20909 19510-19511 NN denotes C
T20908 19509-19510 -LRB- denotes (
T20907 19496-19508 NN denotes technologies
T20906 19483-19495 JJ denotes multiplexing
T20905 19479-19482 CC denotes and
T20904 19473-19478 NN denotes ELISA
T20903 19470-19472 IN denotes by
T20902 19461-19469 VB denotes analyzed
T20901 19456-19460 VB denotes were
T20900 19449-19455 NN denotes levels
T20899 19441-19448 NN denotes protein
T20898 19436-19440 NN denotes IFNα
T20897 19432-19435 CC denotes and
T20896 19427-19431 NN denotes IL-6
T20895 19425-19426 -COMMA- denotes ,
T20894 19420-19425 NN denotes MCP-1
T20893 19418-19419 -COMMA- denotes ,
T20892 19413-19418 NN denotes MIP-2
T20891 19411-19412 -COMMA- denotes ,
T20890 19409-19411 NN denotes KC
T20889 19405-19408 CC denotes and
T20888 19400-19404 NN denotes p.i.
T20887 19395-19399 NN denotes days
T20886 19392-19394 CD denotes 10
T20885 19388-19391 CC denotes and
T20884 19386-19387 CD denotes 7
T20883 19384-19385 -COMMA- denotes ,
T20882 19383-19384 CD denotes 4
T20881 19380-19382 IN denotes at
T20880 19375-19379 NN denotes mice
T20879 19366-19374 JJ denotes infected
T20878 19362-19365 NN denotes IAV
T20877 19357-19361 IN denotes from
T20876 19348-19356 VB denotes isolated
T20875 19344-19347 VB denotes was
T20874 19340-19343 NN denotes BAL
T20873 19328-19338 JJ denotes detectable
T20872 19324-19327 RB denotes not
T20871 19322-19323 -COMMA- denotes ,
T20870 19320-19322 NN denotes ND
T20869 19313-19318 NN denotes limit
T20868 19303-19312 NN denotes detection
T20867 19299-19302 DT denotes the
T20866 19288-19298 VB denotes represents
T20865 19283-19287 NN denotes line
T20864 19276-19282 JJ denotes dashed
T20863 19272-19275 DT denotes The
T20862 19269-19270 -RRB- denotes )
T20861 19268-19269 NN denotes B
T20860 19267-19268 -LRB- denotes (
T20859 19260-19266 NN denotes TCID50
T20858 19255-19259 JJ denotes mean
T20857 19252-19254 IN denotes as
T20856 19242-19251 VB denotes expressed
T20855 19238-19241 CC denotes and
T20854 19229-19237 VB denotes measured
T20853 19224-19228 VB denotes were
T20852 19219-19223 NN denotes lung
T20851 19215-19218 DT denotes the
T20850 19212-19214 IN denotes in
T20849 19205-19211 NN denotes titers
T20848 19199-19204 JJ denotes viral
T20847 19197-19198 -RRB- denotes )
T20846 19193-19197 NN denotes p.i.
T20845 19192-19193 -LRB- denotes (
T20844 19182-19191 NN denotes infection
T20843 19177-19181 NN denotes post
T20842 19174-19176 CD denotes 10
T20841 19170-19173 CC denotes and
T20840 19168-19169 CD denotes 7
T20839 19166-19167 -COMMA- denotes ,
T20838 19165-19166 CD denotes 4
T20837 19161-19164 NN denotes day
T20836 19158-19160 IN denotes At
T20835 19155-19156 -RRB- denotes )
T20834 19154-19155 NN denotes A
T20833 19153-19154 -LRB- denotes (
T20832 19143-19152 VB denotes monitored
T20831 19139-19142 VB denotes was
T20830 19134-19138 NN denotes loss
T20829 19127-19133 NN denotes weight
T20828 19123-19126 CC denotes and
T20827 19119-19122 NN denotes IAV
T20826 19116-19118 IN denotes of
T20825 19111-19115 NN denotes dose
T20824 19101-19110 JJ denotes sublethal
T20823 19099-19100 DT denotes a
T20822 19094-19098 IN denotes with
T20821 19081-19093 RB denotes intranasally
T20820 19072-19080 VB denotes infected
T20819 19067-19071 VB denotes were
T20818 19062-19066 NN denotes mice
T20817 19051-19061 NN denotes A20myel-KO
T20816 19047-19050 CC denotes and
T20815 19036-19046 NN denotes A20myel-WT
T20814 19025-19034 NN denotes infection
T20813 19020-19024 NN denotes lung
T20812 19016-19019 NN denotes IAV
T20811 19008-19015 IN denotes against
T20810 18999-19007 VB denotes protects
T20809 18993-18998 NN denotes cells
T20808 18985-18992 JJ denotes myeloid
T20807 18982-18984 IN denotes in
T20806 18971-18981 NN denotes deficiency
T20805 18967-18970 NN denotes A20
T20474 16704-16709 CD denotes 0,001
T20473 16703-16704 SYM denotes <
T20472 16699-16703 NN denotes ***p
T20471 16686-16698 NN denotes experiments.
T20470 16674-16685 JJ denotes independent
T20469 16672-16673 CD denotes 2
T20468 16668-16671 IN denotes for
T20467 16653-16667 JJ denotes representative
T20466 16649-16652 VB denotes are
T20465 16641-16648 NN denotes Results
T20464 16632-16639 NN denotes samples
T20463 16628-16631 CD denotes 2–3
T20462 16625-16627 IN denotes of
T20461 16623-16624 -RRB- denotes )
T20460 16620-16623 NN denotes SEM
T20459 16616-16619 CC denotes +/−
T20458 16615-16616 -LRB- denotes (
T20457 16608-16614 NN denotes values
T20456 16603-16607 JJ denotes mean
T20455 16593-16602 VB denotes represent
T20454 16588-16592 NN denotes bars
T20453 16582-16587 NN denotes Error
T20452 16579-16580 -RRB- denotes )
T20451 16578-16579 NN denotes D
T20450 16577-16578 -LRB- denotes (
T20449 16564-16576 NN denotes technologies
T20448 16551-16563 JJ denotes multiplexing
T20447 16547-16550 CC denotes and
T20446 16541-16546 NN denotes ELISA
T20445 16538-16540 IN denotes by
T20444 16531-16537 NN denotes levels
T20443 16523-16530 NN denotes protein
T20442 16518-16522 NN denotes IFNβ
T20441 16514-16517 CC denotes and
T20440 16509-16513 NN denotes IL-6
T20439 16505-16508 IN denotes for
T20438 16496-16504 VB denotes analyzed
T20437 16492-16495 VB denotes was
T20436 16480-16491 NN denotes supernatant
T20435 16472-16479 NN denotes culture
T20434 16467-16471 NN denotes Cell
T20433 16464-16465 -RRB- denotes )
T20432 16463-16464 NN denotes C
T20431 16462-16463 -LRB- denotes (
T20430 16457-16461 NN denotes qPCR
T20429 16454-16456 IN denotes by
T20428 16443-16453 VB denotes determined
T20427 16439-16442 VB denotes was
T20426 16428-16438 NN denotes expression
T20425 16423-16427 NN denotes mRNA
T20424 16418-16422 NN denotes IFNβ
T20423 16414-16417 CC denotes and
T20422 16409-16413 NN denotes IL-6
T20421 16390-16395 NN denotes i 1)
T20420 16388-16390 CD denotes mo
T20419 16385-16388 IN denotes V (
T20418 16384-16385 -RRB- denotes A
T20417 16383-16384 CD denotes I
T20416 16379-16382 NN denotes ith
T20415 16378-16379 -LRB- denotes w
T20414 16374-16377 NN denotes ted
T20413 16370-16374 IN denotes nfec
T20412 16362-16370 VB denotes ted or i
T20411 16360-16362 CC denotes ea
T20410 16353-16360 VB denotes mock tr
T20409 16348-16352 JJ denotes were
T20408 16344-16348 VB denotes ges
T20407 16333-16344 NN denotes ar macropha
T20406 16325-16333 JJ denotes ) Alveol
T20405 16324-16325 -RRB- denotes D
T20404 16321-16324 NN denotes (C–
T20403 16319-16320 -LRB- denotes .
T20402 16318-16319 -RRB- denotes )
T20401 16317-16318 NN denotes B
T20400 16316-16317 -LRB- denotes (
T20399 16303-16315 NN denotes technologies
T20398 16290-16302 JJ denotes multiplexing
T20397 16286-16289 CC denotes and
T20396 16280-16285 NN denotes ELISA
T20395 16277-16279 IN denotes by
T20394 16270-16276 NN denotes levels
T20393 16262-16269 NN denotes protein
T20392 16257-16261 NN denotes IFNβ
T20391 16253-16256 CC denotes and
T20390 16249-16252 NN denotes TNF
T20389 16245-16248 IN denotes for
T20388 16236-16244 VB denotes analyzed
T20387 16232-16235 VB denotes was
T20386 16220-16231 NN denotes supernatant
T20385 16212-16219 NN denotes culture
T20384 16207-16211 NN denotes cell
T20383 16197-16206 NN denotes infection
T20382 16192-16196 VB denotes post
T20381 16186-16191 NN denotes hours
T20380 16183-16185 CD denotes 18
T20379 16180-16181 -RRB- denotes )
T20378 16179-16180 NN denotes A
T20377 16178-16179 -LRB- denotes (
T20376 16173-16177 NN denotes qPCR
T20375 16170-16172 IN denotes by
T20374 16161-16169 VB denotes analyzed
T20373 16157-16160 VB denotes was
T20372 16146-16156 NN denotes expression
T20371 16141-16145 NN denotes mRNA
T20370 16137-16140 NN denotes A20
T20369 16133-16136 CC denotes and
T20368 16128-16132 NN denotes IFNβ
T20367 16126-16127 -COMMA- denotes ,
T20366 16122-16126 NN denotes IL-6
T20365 16118-16121 CC denotes and
T20364 16112-16117 VB denotes lysed
T20363 16107-16111 VB denotes were
T20362 16101-16106 NN denotes cells
T20361 16099-16100 -RRB- denotes )
T20360 16095-16099 NN denotes p.i.
T20359 16089-16094 NN denotes hours
T20358 16088-16089 -LRB- denotes (
T20357 16078-16087 NN denotes infection
T20356 16073-16077 NN denotes post
T20355 16067-16072 NN denotes hours
T20354 16057-16066 JJ denotes different
T20353 16054-16056 IN denotes At
T20352 16051-16052 -RRB- denotes )
T20351 16050-16051 CD denotes 1
T20350 16046-16049 NN denotes moi
T20349 16045-16046 -LRB- denotes (
T20348 16041-16044 NN denotes IAV
T20347 16036-16040 IN denotes with
T20346 16027-16035 VB denotes infected
T20345 16022-16026 VB denotes were
T20344 16014-16021 NN denotes animals
T20343 16003-16013 NN denotes A20myel-KO
T20342 15999-16002 CC denotes and
T20341 15988-15998 NN denotes A20myel-WT
T20340 15983-15987 IN denotes from
T20339 15974-15982 VB denotes isolated
T20338 15969-15973 NN denotes BMDM
T20337 15967-15968 -RRB- denotes )
T20336 15964-15967 NN denotes A–B
T20335 15963-15964 -LRB- denotes (
T20334 15950-15961 NN denotes macrophages
T20333 15941-15949 JJ denotes alveolar
T20332 15937-15940 CC denotes and
T20331 15932-15936 NN denotes BMDM
T20330 15929-15931 IN denotes in
T20329 15918-15928 NN denotes expression
T20328 15913-15917 NN denotes gene
T20327 15901-15912 JJ denotes IAV-induced
T20326 15891-15900 VB denotes regulates
T20325 15880-15890 RB denotes negatively
T20324 15876-15879 NN denotes A20
T20950 19712-19717 NN denotes group
T20949 19708-19711 IN denotes per
T19711 12439-12450 NN denotes experiments
T19710 12427-12438 JJ denotes independent
T19709 12425-12426 CD denotes 2
T19708 12422-12424 IN denotes of
T19707 12407-12421 JJ denotes representative
T19706 12403-12406 VB denotes are
T19705 12398-12402 NN denotes Data
T19704 12395-12396 -RRB- denotes )
T19703 12394-12395 NN denotes D
T19669 12234-12240 NN denotes levels
T19668 12229-12233 NN denotes IFNβ
T19667 12225-12228 CC denotes and
T19666 12221-12224 NN denotes TNF
T19665 12219-12220 -COMMA- denotes ,
T19664 12215-12219 NN denotes IL-6
T19663 12212-12213 -RRB- denotes )
T19662 12211-12212 CD denotes 0
T19661 12203-12210 RB denotes  = time
T19660 12201-12202 -COLON- denotes ;
T19659 12197-12201 NN denotes lane
T19658 12191-12196 JJ denotes first
T19657 12187-12190 DT denotes the
T19656 12184-12186 TO denotes to
T19655 12175-12183 VB denotes compared
T19654 12167-12174 NN denotes density
T19653 12158-12166 JJ denotes relative
T19652 12155-12157 IN denotes as
T19651 12145-12154 VB denotes expressed
T19650 12144-12145 -LRB- denotes (
T19649 12137-12143 NN denotes graphs
T19648 12133-12136 NN denotes bar
T19647 12130-12132 IN denotes in
T19646 12124-12129 VB denotes shown
T19645 12121-12123 VB denotes is
T19644 12116-12120 NN denotes IRF3
T19643 12112-12115 CC denotes and
T19642 12108-12111 NN denotes p65
T19641 12100-12107 JJ denotes nuclear
T19640 12096-12099 IN denotes for
T19639 12088-12095 NN denotes density
T19638 12083-12087 NN denotes band
T19637 12080-12082 IN denotes of
T19636 12065-12079 NN denotes Quantification
T19635 12062-12063 -RRB- denotes )
T19634 12061-12062 NN denotes C
T19633 12060-12061 -LRB- denotes (
T19632 12050-12059 NN denotes fractions
T19631 12042-12049 JJ denotes nuclear
T19630 12039-12041 CC denotes or
T19629 12027-12038 JJ denotes cytoplasmic
T19628 12024-12026 IN denotes of
T19627 12009-12023 NN denotes immunoblotting
T19626 12006-12008 IN denotes by
T19625 11997-12005 VB denotes analyzed
T19624 11993-11996 VB denotes was
T19623 11988-11992 NN denotes IRF3
T19622 11984-11987 CC denotes and
T19621 11982-11983 -RRB- denotes )
T19620 11979-11982 NN denotes p65
T19619 11978-11979 -LRB- denotes (
T19618 11972-11977 NN denotes NF-κB
T19617 11969-11971 IN denotes of
T19616 11955-11968 NN denotes translocation
T19615 11947-11954 JJ denotes Nuclear
T19614 11938-11945 NN denotes control
T19613 11930-11937 NN denotes loading
T19612 11928-11929 DT denotes a
T19611 11925-11927 IN denotes as
T19610 11920-11924 VB denotes used
T19609 11917-11919 VB denotes be
T19608 11913-11916 MD denotes can
T19607 11911-11912 -RRB- denotes )
T19606 11903-11911 NN denotes asterisk
T19605 11900-11902 DT denotes an
T19604 11897-11899 IN denotes by
T19603 11887-11896 VB denotes indicated
T19602 11886-11887 -LRB- denotes (
T19601 11877-11885 NN denotes antibody
T19600 11867-11876 JJ denotes anti-IκBα
T19599 11863-11866 DT denotes the
T19598 11860-11862 IN denotes by
T19597 11849-11859 VB denotes recognized
T19596 11832-11848 RB denotes non-specifically
T19595 11829-11831 VB denotes is
T19594 11824-11828 WDT denotes that
T19593 11819-11823 NN denotes band
T19592 11815-11818 DT denotes The
T19591 11812-11813 -RRB- denotes )
T19590 11811-11812 NN denotes B
T19589 11810-11811 -LRB- denotes (
T19588 11801-11809 NN denotes extracts
T19587 11796-11800 NN denotes cell
T19586 11790-11795 JJ denotes total
T19585 11787-11789 IN denotes of
T19584 11772-11786 NN denotes immunoblotting
T19583 11769-11771 IN denotes by
T19582 11753-11768 NN denotes phosphorylation
T19581 11748-11752 NN denotes IRF3
T19580 11744-11747 CC denotes and
T19579 11742-11743 -COMMA- denotes ,
T19578 11731-11742 NN denotes degradation
T19577 11727-11730 CC denotes and
T19576 11711-11726 NN denotes phosphorylation
T19575 11706-11710 NN denotes IκBα
T19574 11702-11705 IN denotes for
T19573 11689-11701 NN denotes transfection
T19572 11686-11688 IN denotes of
T19571 11680-11685 NN denotes start
T19570 11676-11679 DT denotes the
T19569 11670-11675 IN denotes after
T19568 11668-11669 -RRB- denotes )
T19567 11661-11668 NN denotes minutes
T19566 11660-11661 -LRB- denotes (
T19565 11653-11659 NN denotes points
T19564 11648-11652 NN denotes time
T19563 11638-11647 JJ denotes different
T19562 11635-11637 IN denotes at
T19561 11626-11634 VB denotes analyzed
T19560 11622-11625 CC denotes and
T19559 11620-11621 -RRB- denotes )
T19558 11619-11620 NN denotes C
T19557 11618-11619 SYM denotes :
T19556 11617-11618 NN denotes I
T19555 11616-11617 -LRB- denotes (
T19554 11612-11616 NN denotes poly
T19553 11608-11611 NN denotes LMW
T19552 11603-11607 IN denotes with
T19551 11591-11602 VB denotes transfected
T19550 11586-11590 VB denotes were
T19549 11581-11585 NN denotes BMDM
T19548 11579-11580 -RRB- denotes )
T19547 11569-11579 NN denotes A20myel-WT
T19546 11568-11569 -LRB- denotes (
T19545 11563-11567 NN denotes type
T19544 11558-11562 JJ denotes wild
T19543 11554-11557 CC denotes and
T19542 11543-11553 NN denotes A20myel-KO
T19541 11541-11542 -RRB- denotes )
T19540 11538-11541 NN denotes B–D
T19539 11537-11538 -LRB- denotes (
T19538 11529-11536 NN denotes set-up.
T19537 11525-11528 IN denotes per
T19536 11517-11524 NN denotes samples
T19535 11515-11516 CD denotes 3
T19534 11512-11514 IN denotes of
T19533 11509-11511 NN denotes SD
T19532 11505-11508 CC denotes +/−
T19531 11496-11504 NN denotes averages
T19530 11492-11495 VB denotes are
T19529 11484-11491 NN denotes Numbers
T19528 11471-11482 NN denotes luminometer
T19527 11469-11470 DT denotes a
T19526 11466-11468 IN denotes in
T19525 11457-11465 VB denotes analyzed
T19524 11453-11456 VB denotes was
T19523 11444-11452 NN denotes extracts
T19522 11439-11443 NN denotes cell
T19521 11436-11438 IN denotes in
T19520 11427-11435 NN denotes activity
T19519 11416-11426 NN denotes Luciferase
T19518 11411-11414 NN denotes A20
T19517 11408-11410 IN denotes of
T19516 11400-11407 NN denotes amounts
T19515 11389-11399 VB denotes increasing
T19514 11385-11388 CC denotes and
T19513 11383-11384 -RRB- denotes )
T19512 11378-11383 JJ denotes right
T19511 11377-11378 -LRB- denotes (
T19510 11372-11376 NN denotes IRF7
T19509 11370-11371 -COMMA- denotes ,
T19508 11369-11370 -RRB- denotes )
T19507 11364-11369 NN denotes 2CARD
T19506 11363-11364 -LRB- denotes (
T19505 11357-11362 NN denotes RIG-I
T19504 11346-11356 VB denotes expressing
T19503 11337-11345 NN denotes plasmids
T19502 11332-11336 IN denotes with
T19501 11323-11331 RB denotes together
T19500 11321-11322 -COMMA- denotes ,
T19499 11313-11321 NN denotes plasmids
T19498 11311-11312 -RRB- denotes )
T19497 11306-11311 JJ denotes right
T19496 11305-11306 -LRB- denotes (
T19495 11296-11304 NN denotes reporter
T19494 11285-11295 NN denotes luciferase
T19493 11275-11284 JJ denotes dependent
T19492 11270-11274 NN denotes IRF7
T19491 11267-11269 CC denotes or
T19490 11265-11266 -RRB- denotes )
T19489 11259-11265 JJ denotes middle
T19488 11258-11259 -LRB- denotes (
T19487 11253-11257 NN denotes IRF3
T19486 11251-11252 -COMMA- denotes ,
T19485 11250-11251 -RRB- denotes )
T19484 11246-11250 JJ denotes left
T19483 11245-11246 -LRB- denotes (
T19482 11239-11244 NN denotes NF-κB
T19481 11234-11238 IN denotes with
T19480 11222-11233 VB denotes transfected
T19479 11217-11221 VB denotes were
T19478 11211-11216 NN denotes cells
T19477 11203-11210 NN denotes HEK293T
T19476 11201-11202 -RRB- denotes )
T19475 11200-11201 NN denotes A
T19474 11199-11200 -LRB- denotes (
T19473 11186-11197 NN denotes stimulation
T19472 11180-11185 NN denotes RIG-I
T19471 11177-11179 TO denotes to
T19470 11168-11176 NN denotes response
T19469 11165-11167 IN denotes in
T19468 11154-11164 NN denotes activation
T19467 11149-11153 NN denotes IRF3
T19466 11145-11148 CC denotes and
T19465 11139-11144 NN denotes NF-κB
T19464 11130-11138 VB denotes inhibits
T19463 11126-11129 NN denotes A20
T19177 41810-41811 -RRB- denotes )
T19176 41808-41810 NNP denotes CA
T19175 41806-41807 -COMMA- denotes ,
T19174 41801-41806 NNP denotes Diego
T19173 41797-41800 NNP denotes San
T19172 41795-41796 -COMMA- denotes ,
T19171 41787-41795 NNP denotes GraphPad
T19170 41785-41786 -COMMA- denotes ,
T19169 41784-41785 CD denotes 5
T19168 41776-41783 NN denotes version
T19167 41770-41775 NNP denotes Prism
T19166 41761-41769 NNP denotes GraphPad
T19165 41760-41761 -LRB- denotes (
T19164 41755-41759 NN denotes test
T19163 41746-41754 JJ denotes log-rank
T19162 41742-41745 DT denotes the
T19161 41736-41741 VB denotes using
T19160 41729-41735 NN denotes curves
T19159 41716-41728 NNP denotes Kaplan-Meier
T19158 41706-41715 VB denotes comparing
T19157 41703-41705 IN denotes by
T19156 41694-41702 VB denotes analyzed
T19155 41690-41693 VB denotes was
T19154 41684-41689 NN denotes rates
T19153 41675-41683 NN denotes survival
T19152 41667-41674 IN denotes between
T19151 41655-41666 NN denotes differences
T19150 41652-41654 IN denotes of
T19149 41639-41651 NN denotes significance
T19148 41627-41638 JJ denotes Statistical
T19147 41621-41625 NN denotes data
T19146 41612-41620 JJ denotes unpaired
T19145 41608-41611 IN denotes for
T19144 41601-41607 NNP denotes U-test
T19143 41588-41600 NNP denotes Mann-Whitney
T19142 41584-41587 DT denotes the
T19141 41578-41583 VB denotes using
T19140 41567-41577 VB denotes calculated
T19139 41562-41566 VB denotes were
T19138 41560-41561 -RRB- denotes )
T19702 12393-12394 -LRB- denotes (
T19701 12385-12392 NN denotes section
T19700 12376-12384 NN denotes methods’
T19699 12372-12375 CC denotes and
T19698 12361-12371 NN denotes ‘materials
T19697 12357-12360 DT denotes the
T19696 12354-12356 IN denotes in
T19695 12344-12353 VB denotes described
T19694 12341-12343 IN denotes as
T19693 12339-12340 -RRB- denotes )
T19692 12335-12339 NN denotes IFNβ
T19691 12331-12334 CC denotes and
T19690 12327-12330 NN denotes TNF
T19689 12326-12327 -LRB- denotes (
T19688 12320-12325 NN denotes ELISA
T19687 12316-12319 CC denotes and
T19686 12314-12315 -RRB- denotes )
T19685 12310-12314 NN denotes IL-6
T19684 12309-12310 -LRB- denotes (
T19683 12300-12308 NN denotes bioassay
T19682 12297-12299 IN denotes by
T19681 12286-12296 VB denotes determined
T19680 12281-12285 VB denotes were
T19679 12279-12280 -RRB- denotes )
T19678 12278-12279 NN denotes B
T19677 12277-12278 -LRB- denotes (
T19676 12274-12276 IN denotes in
T19675 12269-12273 VB denotes used
T19674 12263-12268 NN denotes cells
T19673 12260-12262 IN denotes of
T19672 12248-12259 NN denotes supernatant
T19671 12244-12247 DT denotes the
T19670 12241-12243 IN denotes in
T19137 41555-41560 NN denotes group
T19136 41551-41554 IN denotes per
T19135 41546-41550 NN denotes mice
T19134 41544-41545 CD denotes 5
T19133 41538-41543 JJ denotes least
T19132 41535-41537 IN denotes at
T19131 41534-41535 -LRB- denotes (
T19130 41522-41533 NN denotes experiments
T19129 41517-41521 FW denotes vivo
T19128 41514-41516 FW denotes in
T19127 41510-41513 IN denotes for
T19126 41498-41509 NN denotes differences
T19125 41494-41497 DT denotes The
T19124 41487-41492 NN denotes ANOVA
T19123 41479-41486 JJ denotes two-way
T19122 41473-41478 VB denotes using
T19121 41464-41472 VB denotes assessed
T19120 41460-41463 VB denotes was
T19119 41453-41459 NN denotes groups
T19118 41445-41452 IN denotes between
T19117 41432-41444 NN denotes significance
T19116 41420-41431 JJ denotes Statistical
T19115 41415-41418 NN denotes SEM
T19114 41413-41414 NN denotes ±
T19113 41408-41412 JJ denotes mean
T19112 41404-41407 DT denotes the
T19111 41401-41403 IN denotes as
T19110 41391-41400 VB denotes expressed
T19109 41387-41390 VB denotes are
T19108 41379-41386 NN denotes Results
T19107 41368-41378 NN denotes Statistics
T18412 40323-40328 NN denotes fluid
T18411 40319-40322 NN denotes BAL
T18410 40316-40318 IN denotes in
T18409 40310-40315 NN denotes MIP-2
T18408 40307-40309 IN denotes of
T18407 40297-40306 NN denotes detection
T18406 40293-40296 DT denotes the
T18405 40289-40292 IN denotes for
T18404 40284-40288 VB denotes used
T18403 40280-40283 VB denotes was
T18402 40278-40279 -RRB- denotes )
T18401 40269-40278 NN denotes Millipore
T18400 40268-40269 -LRB- denotes (
T18399 40257-40267 NN denotes technology
T18398 40247-40256 NNP denotes Milliplex
T18397 40233-40245 NN denotes instructions
T18396 40230-40232 POS denotes 's
T18395 40218-40230 NN denotes manufacturer
T18394 40214-40217 DT denotes the
T18393 40211-40213 TO denotes to
T18392 40201-40210 VB denotes according
T18391 40190-40200 NN denotes technology
T18390 40188-40189 -RRB- denotes )
T18389 40182-40188 NNP denotes BioRad
T18388 40181-40182 -LRB- denotes (
T18387 40173-40180 NNP denotes Bioplex
T18386 40167-40172 VB denotes using
T18385 40157-40166 VB denotes performed
T18384 40153-40156 VB denotes was
T18383 40147-40152 NN denotes fluid
T18382 40143-40146 NN denotes BAL
T18381 40140-40142 IN denotes in
T18380 40135-40139 NN denotes IL-6
T18379 40131-40134 CC denotes and
T18378 40125-40130 NN denotes IL-1β
T18377 40123-40124 -COMMA- denotes ,
T18376 40120-40123 NN denotes TNF
T18375 40118-40119 -COMMA- denotes ,
T18374 40116-40118 NN denotes KC
T18373 40114-40115 -COMMA- denotes ,
T18372 40109-40114 NN denotes MCP-1
T18371 40106-40108 IN denotes of
T18370 40096-40105 NN denotes Detection
T18369 40093-40094 -RRB- denotes )
T18368 40081-40093 NN denotes eBiosciences
T18367 40080-40081 -LRB- denotes (
T18366 40069-40079 NN denotes antibodies
T18365 40067-40068 -RRB- denotes )
T18364 40061-40067 NN denotes R4-6A2
T18363 40060-40061 -LRB- denotes (
T18362 40050-40059 NN denotes detection
T18361 40046-40049 CC denotes and
T18360 40044-40045 -RRB- denotes )
T18359 40038-40044 NN denotes XMG1.2
T18358 40037-40038 -LRB- denotes (
T18357 40029-40036 NN denotes coating
T18356 40024-40028 NN denotes IFNγ
T18355 40019-40023 IN denotes with
T18354 40012-40018 VB denotes coated
T18353 40007-40011 VB denotes were
T18352 40000-40006 NN denotes plates
T18351 39992-39999 JJ denotes 96-well
T18350 39990-39991 -COMMA- denotes ,
T18349 39985-39990 NNP denotes ELISA
T18348 39980-39984 NNP denotes IFNγ
T18347 39976-39979 IN denotes For
T18346 39973-39974 -RRB- denotes )
T18345 39961-39973 NNP denotes Laboratories
T18344 39950-39960 NNP denotes Biomedical
T18343 39946-39949 NN denotes PBL
T18342 39945-39946 -LRB- denotes (
T18341 39941-39944 NN denotes kit
T18340 39935-39940 NN denotes ELISA
T18339 39932-39934 DT denotes an
T18338 39927-39931 IN denotes with
T18337 39916-39926 VB denotes determined
T18336 39911-39915 VB denotes were
T18335 39904-39910 NN denotes levels
T18334 39896-39903 NN denotes protein
T18333 39891-39895 NN denotes IFNβ
T18332 39887-39890 CC denotes and
T18331 39882-39886 NN denotes IFNα
T18330 39870-39880 NN denotes antibodies
T18329 39868-39869 -RRB- denotes )
T18328 39857-39868 NN denotes eBioscience
T18327 39855-39856 -COMMA- denotes ,
T18326 39849-39855 NN denotes R4-6A2
T18325 39848-39849 -LRB- denotes (
T18324 39838-39847 NN denotes detection
T18323 39834-39837 CC denotes and
T18322 39832-39833 -RRB- denotes )
T18321 39821-39832 NN denotes eBioscience
T18320 39819-39820 -COMMA- denotes ,
T18319 39813-39819 NN denotes TN3-19
T18318 39812-39813 -LRB- denotes (
T18317 39804-39811 NN denotes coating
T18316 39800-39803 NN denotes TNF
T18315 39795-39799 IN denotes with
T18314 39788-39794 VB denotes coated
T18313 39783-39787 VB denotes were
T18312 39776-39782 NN denotes plates
T18311 39768-39775 JJ denotes 96-well
T18310 39766-39767 -COMMA- denotes ,
T18309 39761-39766 NN denotes ELISA
T18308 39757-39760 NN denotes TNF
T18307 39753-39756 IN denotes For
T18306 39738-39752 NN denotes quantification
T18305 39729-39737 NN denotes Cytokine
T18830 41359-41365 NN denotes values
T18829 41354-41358 NN denotes HPRT
T18828 41351-41353 TO denotes to
T18827 41342-41350 JJ denotes relative
T18826 41332-41341 VB denotes expressed
T18825 41328-41331 VB denotes are
T18824 41320-41327 NN denotes Results
T18823 41317-41318 -RRB- denotes )
T18822 41313-41317 NN denotes ΔΔCT
T18821 41312-41313 -LRB- denotes (
T18820 41305-41311 NN denotes method
T18819 41302-41304 NN denotes CT
T18818 41290-41301 JJ denotes comparative
T18817 41286-41289 DT denotes the
T18816 41280-41285 VB denotes using
T18815 41270-41279 VB denotes performed
T18814 41266-41269 VB denotes was
T18813 41251-41265 NN denotes Quantification
T18812 41248-41249 -RRB- denotes )
T18811 41220-41248 LS denotes //perlprimer.sourceforge.net
T18810 41219-41220 -COLON- denotes :
T18809 41215-41219 NN denotes http
T18808 41214-41215 -LRB- denotes (
T18807 41203-41213 NN denotes PerlPrimer
T18806 41198-41202 IN denotes with
T18805 41189-41197 VB denotes designed
T18804 41184-41188 VB denotes were
T18803 41176-41183 NN denotes Primers
T18802 41146-41174 NN denotes 5′-GATCTCTTAGCACAAGGATGGC-3′
T18801 41142-41145 CC denotes and
T18800 41113-41141 NN denotes 5′-TGATGAGCTACTACTGGTCAGC-3′
T18799 41111-41112 -COLON- denotes :
T18798 41106-41111 NN denotes IFNα4
T18797 41102-41105 CC denotes and
T18796 41075-41101 NN denotes 5′-TGAGTGTGGCTATGACTTCG-3′
T18795 41071-41074 CC denotes and
T18794 41044-41070 NN denotes 5′-GAGCCTCTAACCAGTTCCAG-3′
T18793 41042-41043 -COLON- denotes :
T18792 41037-41042 NN denotes CXCL1
T18791 41035-41036 -COLON- denotes ;
T18790 41006-41035 NN denotes 5′-GCATTAGCTTCAGATTTACGGGT-3′
T18789 41002-41005 CC denotes and
T18788 40972-41001 NN denotes 5′-TTAAAAACCTGGATCGGAACCAA-3′
T18787 40970-40971 -COLON- denotes :
T18786 40966-40970 NN denotes CCL2
T18785 40964-40965 -COLON- denotes ;
T18784 40938-40964 NN denotes 5′-GTTGTCCCATTCGTCATTCC-3′
T18783 40934-40937 CC denotes and
T18782 40905-40933 NN denotes 5′-AAACCAATGGTGATGGAAACTG-3′
T18781 40903-40904 -COLON- denotes :
T18780 40900-40903 NN denotes A20
T18779 40898-40899 -COLON- denotes ;
T18778 40868-40898 NN denotes 5′-GACCTTTCAAATGCAGTAGATTCA-3′
T18777 40864-40867 CC denotes and
T18776 40837-40863 NN denotes 5′-TCAGAATGAGTGGTGGTTGC-3′
T18775 40835-40836 -COLON- denotes :
T18774 40831-40835 NN denotes IFNβ
T18773 40829-40830 -COLON- denotes ;
T18772 40799-40829 NN denotes 5′-AAGTGCATCATCGTTGTTCATACA-3′
T18771 40795-40798 CC denotes and
T18770 40765-40794 NN denotes 5′-GAGGATACCACTCCCAACAGACC-3′
T18769 40763-40764 -COLON- denotes :
T18768 40759-40763 NN denotes IL-6
T18767 40757-40758 -COLON- denotes ;
T18766 40731-40757 NN denotes 5′CGTGATTCAAATCCCTGAAGT-3′
T18765 40727-40730 CC denotes and
T18764 40699-40726 NN denotes 5′-AGTGTTGGATACAGGCCAGAC-3′
T18763 40697-40698 -COLON- denotes :
T18762 40693-40697 NN denotes HPRT
T18761 40691-40692 -COLON- denotes :
T18760 40684-40691 NN denotes primers
T18759 40674-40683 VB denotes following
T18758 40670-40673 DT denotes the
T18757 40665-40669 IN denotes with
T18756 40663-40664 -RRB- denotes )
T18755 40658-40663 NN denotes Roche
T18754 40657-40658 -LRB- denotes (
T18753 40650-40656 NN denotes system
T18752 40640-40649 NN denotes detection
T18751 40636-40639 CD denotes 480
T18750 40624-40635 NNP denotes Lightcycler
T18749 40620-40623 DT denotes the
T18748 40617-40619 IN denotes in
T18747 40615-40616 -RRB- denotes )
T18746 40610-40615 NNP denotes Roche
T18745 40609-40610 -LRB- denotes (
T18744 40607-40608 CD denotes I
T18743 40603-40606 NN denotes mix
T18742 40596-40602 NN denotes master
T18741 40594-40595 NNP denotes I
T18740 40588-40593 NNP denotes Green
T18739 40583-40587 NNP denotes SYBR
T18738 40577-40582 VB denotes using
T18737 40574-40576 IN denotes by
T18736 40564-40573 VB denotes performed
T18735 40560-40563 VB denotes was
T18734 40555-40559 NN denotes qPCR
T18733 40541-40554 NN denotes instructions.
T18732 40538-40540 POS denotes 's
T18731 40526-40538 NN denotes manufacturer
T18730 40522-40525 DT denotes the
T18729 40519-40521 TO denotes to
T18728 40509-40518 VB denotes according
T18727 40507-40508 -RRB- denotes )
T18726 40501-40507 NN denotes BioRad
T18725 40500-40501 -LRB- denotes (
T18724 40496-40499 NN denotes kit
T18723 40486-40495 NN denotes synthesis
T18722 40481-40485 NN denotes cDNA
T18721 40473-40480 NN denotes iScript
T18720 40468-40472 IN denotes with
T18719 40463-40467 NN denotes cDNA
T18718 40458-40462 IN denotes into
T18717 40446-40457 VB denotes transcribed
T18716 40438-40445 NN denotes reverse
T18715 40434-40437 CC denotes and
T18714 40432-40433 -RRB- denotes )
T18713 40426-40432 NN denotes BioRad
T18712 40425-40426 -LRB- denotes (
T18711 40421-40424 NN denotes kit
T18710 40416-40420 NN denotes mini
T18709 40412-40415 NN denotes RNA
T18708 40406-40411 NNP denotes Total
T18707 40400-40405 NNP denotes Aurum
T18706 40394-40399 VB denotes using
T18705 40384-40393 VB denotes extracted
T18704 40380-40383 VB denotes was
T18703 40376-40379 NN denotes RNA
T18702 40370-40375 JJ denotes Total
T18701 40365-40369 NN denotes qPCR
T18700 40361-40364 CC denotes and
T18699 40351-40360 NN denotes synthesis
T18698 40346-40350 NN denotes cDNA
T18697 40344-40345 -COMMA- denotes ,
T18696 40335-40344 NN denotes isolation
T18695 40331-40334 NN denotes RNA
T17943 39707-39711 JJ denotes live
T17942 39699-39706 IN denotes between
T17941 39686-39698 VB denotes discriminate
T17940 39683-39685 TO denotes to
T17939 39678-39682 VB denotes used
T17938 39674-39677 VB denotes was
T17937 39667-39673 NN denotes iodide
T17936 39657-39666 NN denotes Propidium
T17935 39153-39157 NN denotes EDTA
T17934 39150-39152 NN denotes mM
T17933 39148-39149 CD denotes 1
T17932 39143-39147 IN denotes with
T17931 39138-39142 NN denotes HBSS
T17930 39133-39137 IN denotes with
T17929 39127-39132 NN denotes times
T17928 39125-39126 CD denotes 4
T17927 39117-39124 VB denotes flushed
T17926 39113-39116 VB denotes was
T17925 39107-39112 NN denotes lumen
T17924 39100-39106 NN denotes airway
T17923 39096-39099 CC denotes and
T17922 39086-39095 VB denotes canulated
T17921 39081-39085 VB denotes were
T17920 39073-39080 NN denotes trachea
T17919 39071-39072 -COMMA- denotes ,
T17918 39068-39071 NN denotes BAL
T17917 39065-39067 IN denotes of
T17916 39053-39064 NN denotes preparation
T17915 39049-39052 DT denotes the
T17914 39045-39048 IN denotes For
T17913 39039-39043 NN denotes mesh
T17912 39033-39038 NN denotes nylon
T17911 39030-39032 NN denotes µm
T17910 39027-39029 CD denotes 40
T17909 39023-39026 CC denotes and
T17908 39020-39022 NN denotes µm
T17907 39017-39019 CD denotes 70
T17906 39015-39016 DT denotes a
T17905 39007-39014 IN denotes through
T17904 38998-39006 VB denotes filtered
T17903 38993-38997 VB denotes were
T17902 38985-38992 NN denotes samples
T17901 38983-38984 -COMMA- denotes ,
T17900 38971-38983 RB denotes Subsequently
T17899 38966-38969 NN denotes min
T17898 38963-38965 CD denotes 30
T17897 38959-38962 IN denotes for
T17896 38954-38958 NN denotes 37°C
T17895 38951-38953 IN denotes at
T17894 38949-38950 -RRB- denotes )
T17893 38944-38949 NNP denotes Roche
T17892 38942-38943 -COLON- denotes ;
T17891 38938-38942 NN denotes U/ml
T17890 38934-38937 CD denotes 100
T17889 38933-38934 -LRB- denotes (
T17888 38927-38932 NN denotes DNAse
T17887 38923-38926 CC denotes and
T17886 38921-38922 -RRB- denotes )
T17885 38916-38921 NNP denotes Sigma
T17884 38914-38915 -COLON- denotes ;
T17883 38909-38914 NN denotes mg/ml
T17882 38907-38908 CD denotes 1
T17881 38906-38907 -LRB- denotes (
T17880 38903-38905 CD denotes IV
T17879 38898-38902 NN denotes type
T17878 38886-38897 NN denotes collagenase
T17877 38881-38885 IN denotes with
T17876 38871-38880 VB denotes incubated
T17875 38867-38870 CC denotes and
T17874 38857-38866 VB denotes dissected
T17873 38852-38856 VB denotes were
T17872 38846-38851 NN denotes Lungs
T17871 38836-38845 NN denotes cytometry
T17870 38831-38835 NN denotes Flow
T17946 39721-39726 NN denotes cells
T17945 39716-39720 JJ denotes dead
T17944 39712-39715 CC denotes and
T16818 37489-37500 NN denotes antibiotics
T16817 37485-37488 CC denotes and
T16816 37476-37484 NN denotes pyruvate
T16815 37469-37475 NN denotes sodium
T16814 37466-37468 NN denotes mM
T16813 37462-37465 CD denotes 0.4
T16812 37460-37461 -COMMA- denotes ,
T16811 37449-37460 NN denotes L-glutamine
T16810 37446-37448 NN denotes mM
T16809 37444-37445 CD denotes 2
T16808 37442-37443 -COMMA- denotes ,
T16807 37439-37442 NN denotes FCS
T16806 37437-37438 NN denotes %
T16805 37436-37437 CD denotes 1
T16804 37431-37435 IN denotes with
T16803 37418-37430 VB denotes supplemented
T16802 37416-37417 -RRB- denotes )
T16801 37411-37416 NNP denotes Gibco
T16800 37410-37411 -LRB- denotes (
T16799 37405-37409 CD denotes 1640
T16798 37400-37404 NN denotes RPMI
T16797 37397-37399 IN denotes in
T16796 37388-37396 VB denotes cultured
T16795 37383-37387 VB denotes were
T16794 37371-37382 NN denotes macrophages
T16793 37362-37370 JJ denotes Alveolar
T16792 37356-37360 NN denotes EDTA
T16791 37353-37355 NN denotes mM
T16790 37351-37352 CD denotes 1
T16789 37340-37350 VB denotes containing
T16788 37335-37339 NN denotes HBSS
T16787 37330-37334 IN denotes with
T16786 37324-37329 NN denotes times
T16785 37322-37323 CD denotes 4
T16784 37314-37321 VB denotes flushed
T16783 37310-37313 VB denotes was
T16782 37305-37309 NN denotes lung
T16781 37301-37304 DT denotes the
T16780 37297-37300 CC denotes and
T16779 37287-37296 VB denotes canulated
T16778 37283-37286 VB denotes was
T16777 37275-37282 NN denotes trachea
T16776 37271-37274 DT denotes the
T16775 37269-37270 -COMMA- denotes ,
T16774 37258-37269 NN denotes macrophages
T16773 37249-37257 JJ denotes alveolar
T16772 37246-37248 IN denotes of
T16771 37236-37245 NN denotes isolation
T16770 37232-37235 DT denotes the
T16769 37228-37231 IN denotes For
T16768 37216-37226 NN denotes antibodies
T16767 37207-37215 JJ denotes specific
T16766 37201-37206 NN denotes CD11b
T16765 37197-37200 CC denotes and
T16764 37191-37196 NN denotes F4/80
T16763 37185-37190 VB denotes using
T16762 37175-37184 NN denotes cytometry
T16761 37170-37174 NN denotes flow
T16760 37167-37169 IN denotes by
T16759 37158-37166 VB denotes measured
T16758 37155-37157 IN denotes as
T16757 37148-37154 NN denotes purity
T16756 37146-37147 NN denotes %
T16755 37143-37146 CD denotes ≥95
T16754 37140-37142 IN denotes of
T16753 37135-37139 VB denotes were
T16752 37130-37134 NN denotes BMDM
T16751 37123-37128 NN denotes M-CSF
T16750 37111-37122 JJ denotes recombinant
T16749 37105-37110 NN denotes ng/ml
T16748 37102-37104 CD denotes 40
T16747 37098-37101 CC denotes and
T16746 37086-37097 NN denotes antibiotics
T16745 37084-37085 -COMMA- denotes ,
T16744 37076-37084 NN denotes pyruvate
T16743 37069-37075 NN denotes sodium
T16742 37066-37068 NN denotes mM
T16741 37062-37065 CD denotes 0.4
T16740 37060-37061 -COMMA- denotes ,
T16739 37049-37060 NN denotes L-glutamine
T16738 37046-37048 NN denotes mM
T16737 37044-37045 CD denotes 2
T16736 37042-37043 -COMMA- denotes ,
T16735 37039-37042 NN denotes FCS
T16734 37037-37038 NN denotes %
T16733 37035-37037 CD denotes 10
T16732 37030-37034 IN denotes with
T16731 37017-37029 VB denotes supplemented
T16730 37015-37016 -RRB- denotes )
T16729 37010-37015 NNP denotes Gibco
T16728 37009-37010 -LRB- denotes (
T16727 37004-37008 CD denotes 1640
T16726 36999-37003 NN denotes RPMI
T16725 36996-36998 IN denotes in
T16724 36991-36995 NN denotes days
T16723 36989-36990 CD denotes 7
T16722 36980-36988 VB denotes cultured
T16721 36975-36979 VB denotes were
T16720 36969-36974 NN denotes cells
T16719 36962-36968 NN denotes marrow
T16718 36957-36961 NN denotes bone
T16717 36955-36956 -COMMA- denotes ,
T16716 36951-36955 NN denotes BMDM
T16715 36948-36950 IN denotes of
T16714 36937-36947 NN denotes generation
T16713 36933-36936 DT denotes the
T16712 36929-36932 IN denotes For
T16711 36901-36927 VB denotes //bccm.belspo.be/index.php
T16710 36900-36901 -COLON- denotes :
T16709 36896-36900 NN denotes http
T16708 36887-36895 NN denotes databank
T16707 36879-36886 NN denotes plasmid
T16706 36869-36878 NN denotes BCCM-LMBP
T16705 36865-36868 DT denotes the
T16704 36862-36864 IN denotes at
T16703 36857-36861 NN denotes maps
T16702 36848-36856 NN denotes sequence
T16701 36839-36847 JJ denotes detailed
T16700 36834-36838 IN denotes with
T16699 36828-36833 IN denotes along
T16698 36818-36827 VB denotes presented
T16697 36814-36817 VB denotes are
T16696 36805-36813 NN denotes plasmids
T16695 36802-36804 IN denotes of
T16694 36794-36801 NN denotes Details
T16693 36779-36792 NN denotes normalization
T16692 36768-36778 NN denotes efficiency
T16691 36755-36767 NN denotes transfection
T16690 36751-36754 IN denotes for
T16689 36749-36750 -RRB- denotes )
T16688 36741-36749 NN denotes LMBP4341
T16687 36740-36741 -LRB- denotes (
T16686 36728-36739 NN denotes pACTbetagal
T16685 36724-36727 CC denotes and
T16684 36722-36723 -COMMA- denotes ,
T16683 36721-36722 -RRB- denotes )
T16682 36715-36721 NNP denotes Canada
T16681 36713-36714 -COMMA- denotes ,
T16680 36707-36713 NNP denotes Quebec
T16679 36705-36706 -COMMA- denotes ,
T16678 36697-36705 NNP denotes Montreal
T16677 36695-36696 -COMMA- denotes ,
T16676 36685-36695 NNP denotes University
T16675 36678-36684 NNP denotes McGill
T16674 36676-36677 -COMMA- denotes ,
T16673 36669-36676 NNP denotes Hiscott
T16672 36666-36668 NNP denotes J.
T16671 36663-36665 IN denotes by
T16670 36654-36662 VB denotes provided
T16669 36647-36653 RB denotes kindly
T16668 36646-36647 -LRB- denotes (
T16667 36631-36645 NN denotes pGL3-IFNα4-luc
T16666 36629-36630 -COMMA- denotes ,
T16665 36628-36629 -RRB- denotes )
T16664 36620-36628 NN denotes LMBP4011
T16663 36619-36620 -LRB- denotes (
T16662 36609-36618 NN denotes pISRE-luc
T16661 36607-36608 -COMMA- denotes ,
T16660 36606-36607 -RRB- denotes )
T16659 36598-36606 NN denotes LMBP3248
T16658 36597-36598 -LRB- denotes (
T16657 36589-36596 NN denotes pConLuc
T16656 36576-36588 RB denotes respectively
T16655 36575-36576 -LRB- denotes (
T16654 36566-36574 NN denotes plasmids
T16653 36557-36565 NN denotes reporter
T16652 36552-36556 NN denotes IRF7
T16651 36550-36551 -COMMA- denotes ,
T16650 36546-36550 NN denotes IRF3
T16649 36544-36545 -COMMA- denotes ,
T16648 36539-36544 NN denotes NF-κB
T16647 36537-36538 -COMMA- denotes ,
T16646 36536-36537 -RRB- denotes )
T16645 36535-36536 -RRB- denotes )
T16644 36530-36535 NNP denotes Tokyo
T16643 36527-36529 IN denotes of
T16642 36516-36526 NNP denotes University
T16641 36514-36515 -COMMA- denotes ,
T16640 36506-36514 NNP denotes Medicine
T16639 36503-36505 IN denotes of
T16638 36495-36502 NNP denotes Faculty
T17441 38827-38828 -RRB- denotes )
T17440 38826-38827 CD denotes 0
T17439 38818-38825 RB denotes  = time
T17438 38817-38818 -LRB- denotes (
T17437 38812-38816 NN denotes lane
T17436 38806-38811 JJ denotes first
T17435 38802-38805 DT denotes the
T17434 38799-38801 TO denotes to
T17433 38790-38798 JJ denotes relative
T17432 38779-38789 VB denotes calculated
T17431 38774-38778 VB denotes were
T17430 38762-38773 NN denotes intensities
T17429 38758-38761 DT denotes All
T17428 38752-38756 NN denotes tool
T17427 38743-38751 NN denotes analyzer
T17426 38739-38742 NN denotes Gel
T17425 38737-38738 -RRB- denotes )
T17424 38718-38737 LS denotes //rsbweb.nih.gov/ij
T17423 38717-38718 -COLON- denotes :
T17422 38713-38717 NN denotes http
T17421 38712-38713 -LRB- denotes (
T17420 38705-38711 NN denotes ImageJ
T17419 38701-38704 DT denotes the
T17418 38696-38700 IN denotes with
T17417 38694-38695 -RRB- denotes )
T17416 38685-38694 NN denotes induction
T17415 38680-38684 JJ denotes fold
T17414 38679-38680 -LRB- denotes (
T17413 38668-38678 VB denotes quantified
T17412 38664-38667 VB denotes was
T17411 38658-38663 NN denotes bands
T17410 38654-38657 DT denotes the
T17409 38651-38653 IN denotes of
T17408 38643-38650 NN denotes density
T17407 38639-38642 DT denotes The
T17406 38636-38637 -RRB- denotes )
T17405 38625-38636 NN denotes Biomedicals
T17404 38622-38624 NN denotes MP
T17403 38621-38622 -LRB- denotes (
T17402 38610-38620 JJ denotes anti-actin
T17401 38606-38609 CC denotes and
T17400 38604-38605 -RRB- denotes )
T17399 38595-38604 NN denotes Signaling
T17398 38590-38594 NN denotes Cell
T17397 38589-38590 -LRB- denotes (
T17396 38571-38588 JJ denotes anti-phospho-IκBα
T17395 38567-38570 CC denotes and
T17394 38549-38566 JJ denotes anti-phospho-IRF3
T17393 38547-38548 -COMMA- denotes ,
T17392 38546-38547 -RRB- denotes )
T17391 38536-38546 NN denotes Invitrogen
T17390 38535-38536 -LRB- denotes (
T17331 38195-38198 CD denotes 0.5
T17330 38193-38194 -COMMA- denotes ,
T17329 38185-38193 NN denotes glycerol
T17328 38183-38184 NN denotes %
T17327 38181-38183 CD denotes 20
T17326 38179-38180 -COMMA- denotes ,
T17325 38174-38179 NN denotes MgCl2
T17324 38171-38173 NN denotes mM
T17323 38169-38170 CD denotes 1
T17322 38167-38168 -COMMA- denotes ,
T17321 38164-38167 NN denotes KCl
T17320 38161-38163 NN denotes mM
T17319 38158-38160 CD denotes 10
T17318 38156-38157 -COMMA- denotes ,
T17317 38152-38156 NN denotes NaCl
T17316 38149-38151 NN denotes mM
T17315 38145-38148 CD denotes 400
T17314 38143-38144 -COMMA- denotes ,
T17313 38138-38143 NN denotes NP-40
T17312 38136-38137 NN denotes %
T17311 38135-38136 CD denotes 1
T17310 38133-38134 -COMMA- denotes ,
T17309 38130-38133 CD denotes 7.5
T17308 38127-38129 NN denotes pH
T17307 38121-38126 NNP denotes Hepes
T17306 38118-38120 NN denotes mM
T17305 38115-38117 CD denotes 20
T17304 38114-38115 -LRB- denotes (
T17303 38111-38113 NN denotes B2
T17302 38108-38110 IN denotes in
T17301 38102-38107 VB denotes lyzed
T17300 38098-38101 VB denotes was
T17299 38091-38097 NN denotes pellet
T17298 38080-38090 VB denotes containing
T17297 38071-38079 NN denotes fraction
T17296 38063-38070 JJ denotes nuclear
T17295 38059-38062 DT denotes The
T17294 38054-38057 NN denotes min
T17293 38052-38053 CD denotes 5
T17292 38048-38051 IN denotes for
T17291 38046-38047 NN denotes g
T17290 38042-38045 CD denotes 500
T17289 38039-38041 IN denotes at
T17288 38027-38038 VB denotes centrifuged
T17287 38022-38026 VB denotes were
T17286 38016-38021 NN denotes cells
T17285 38012-38015 CC denotes and
T17284 38010-38011 NN denotes %
T17283 38006-38010 CD denotes 0.65
T17282 38003-38005 IN denotes of
T17281 37989-38002 NN denotes concentration
T17280 37983-37988 JJ denotes final
T17279 37981-37982 DT denotes a
T17278 37978-37980 TO denotes to
T17277 37972-37977 VB denotes added
T17276 37968-37971 VB denotes was
T17275 37958-37967 NN denotes detergent
T17274 37952-37957 NN denotes NP-40
T17273 37950-37951 -COMMA- denotes ,
T17272 37946-37950 NNP denotes Next
T17271 37941-37945 NNP denotes 4°C.
T17270 37938-37940 IN denotes at
T17269 37934-37937 NN denotes min
T17268 37931-37933 CD denotes 15
T17267 37927-37930 IN denotes for
T17266 37925-37926 -RRB- denotes )
T17265 37915-37925 NN denotes inhibitors
T17264 37903-37914 NN denotes phosphatase
T17263 37899-37902 CC denotes and
T17262 37890-37898 NN denotes protease
T17261 37885-37889 IN denotes with
T17260 37872-37884 VB denotes supplemented
T17259 37867-37871 NN denotes EGTA
T17258 37864-37866 NN denotes mM
T17257 37860-37863 CD denotes 0.1
T17256 37856-37859 CC denotes and
T17255 37851-37855 NN denotes EDTA
T17254 37848-37850 NN denotes mM
T17253 37844-37847 CD denotes 0.5
T17252 37842-37843 -COMMA- denotes ,
T17251 37834-37842 NN denotes glycerol
T17250 37832-37833 NN denotes %
T17249 37831-37832 CD denotes 5
T17248 37829-37830 -COMMA- denotes ,
T17247 37824-37829 NN denotes MgCl2
T17246 37821-37823 NN denotes mM
T17245 37819-37820 CD denotes 1
T17244 37817-37818 -COMMA- denotes ,
T17243 37814-37817 NN denotes KCl
T17242 37811-37813 NN denotes mM
T17241 37808-37810 CD denotes 10
T17240 37806-37807 -COMMA- denotes ,
T17239 37803-37806 CD denotes 7.5
T17238 37800-37802 NN denotes pH
T17237 37794-37799 NNP denotes Hepes
T17236 37791-37793 NN denotes mM
T17235 37788-37790 CD denotes 10
T17234 37787-37788 -LRB- denotes (
T17233 37784-37786 NN denotes B1
T17232 37781-37783 IN denotes in
T17231 37775-37780 NN denotes cells
T17230 37762-37774 VB denotes resuspending
T17229 37759-37761 IN denotes by
T17228 37750-37758 VB denotes prepared
T17227 37745-37749 VB denotes were
T17226 37737-37744 NN denotes lysates
T17225 37725-37736 JJ denotes cytoplasmic
T17224 37721-37724 CC denotes and
T17223 37713-37720 JJ denotes Nuclear
T17222 37701-37711 NN denotes inhibitors
T17221 37689-37700 NN denotes phosphatase
T17220 37685-37688 CC denotes and
T17219 37676-37684 NN denotes protease
T17218 37671-37675 IN denotes with
T17217 37658-37670 VB denotes supplemented
T17216 37656-37657 -RRB- denotes )
T17215 37653-37656 NN denotes DTT
T17214 37650-37652 NN denotes mM
T17213 37648-37649 CD denotes 2
T17212 37646-37647 -COMMA- denotes ,
T17211 37642-37646 NN denotes EDTA
T17210 37639-37641 NN denotes mM
T17209 37637-37638 CD denotes 5
T17208 37635-37636 -COMMA- denotes ,
T17207 37632-37635 CD denotes 7.5
T17206 37629-37631 NN denotes pH
T17205 37620-37628 NN denotes Tris-HCl
T17204 37617-37619 NN denotes mM
T17203 37614-37616 CD denotes 10
T17202 37612-37613 -COMMA- denotes ,
T17201 37607-37612 NN denotes NP-40
T17200 37605-37606 NN denotes %
T17199 37604-37605 CD denotes 1
T17198 37602-37603 -COMMA- denotes ,
T17197 37598-37602 NN denotes NaCl
T17196 37595-37597 NN denotes mM
T17195 37591-37594 CD denotes 200
T17194 37590-37591 -LRB- denotes (
T17193 37583-37589 NN denotes buffer
T17192 37577-37582 NN denotes lysis
T17191 37574-37576 IN denotes in
T17190 37570-37573 NN denotes min
T17189 37567-37569 CD denotes 15
T17188 37563-37566 IN denotes for
T17187 37559-37562 NN denotes 4°C
T17186 37556-37558 IN denotes at
T17185 37550-37555 VB denotes lysed
T17184 37545-37549 VB denotes were
T17183 37539-37544 NN denotes cells
T17182 37537-37538 -COMMA- denotes ,
T17181 37530-37537 NN denotes lysates
T17180 37524-37529 JJ denotes total
T17179 37520-37523 IN denotes For
T17178 37511-37519 NN denotes blotting
T17177 37503-37510 NN denotes Western
T16637 36491-36494 CC denotes and
T16636 36482-36490 NNP denotes Medicine
T16635 36479-36481 IN denotes of
T16634 36472-36478 NNP denotes School
T16633 36463-36471 NNP denotes Graduate
T16632 36461-36462 -COMMA- denotes ,
T16631 36452-36461 NNP denotes Taniguchi
T16630 36449-36451 NNP denotes T.
T16629 36446-36448 IN denotes by
T16628 36437-36445 VB denotes provided
T16627 36430-36436 RB denotes kindly
T16626 36429-36430 -LRB- denotes (
T16625 36416-36428 NN denotes pEF-HA-IRF-7
T16624 36414-36415 -COMMA- denotes ,
T16623 36413-36414 -RRB- denotes )
T16622 36409-36413 CD denotes 6517
T16621 36404-36408 NN denotes LMBP
T16620 36403-36404 -LRB- denotes (
T16619 36383-36402 NN denotes pCAGGS-E-RIG-I-CARD
T16618 36381-36382 -COMMA- denotes ,
T16617 36380-36381 -RRB- denotes )
T16616 36376-36380 CD denotes 3778
T16615 36371-36375 NN denotes LMBP
T16614 36370-36371 -LRB- denotes (
T16613 36356-36369 NN denotes pCAGGS-E-hA20
T16612 36355-36356 -LRB- denotes (
T16576 36130-36132 IN denotes in
T16575 36124-36129 VB denotes grown
T16574 36119-36123 VB denotes were
T16573 36113-36118 NN denotes cells
T16572 36108-36112 NN denotes MDCK
T16571 36104-36107 CC denotes and
T16570 36096-36103 NN denotes HEK293T
T16569 36083-36095 NN denotes transfection
T16568 36079-36082 CC denotes and
T16567 36073-36078 NN denotes Cells
T15022 32778-32786 VB denotes provided
T17389 38525-38534 NN denotes anti-IRF3
T17388 38523-38524 -COMMA- denotes ,
T17387 38522-38523 -RRB- denotes )
T17386 38518-38522 NNP denotes Cruz
T17385 38512-38517 NNP denotes Santa
T17384 38511-38512 -LRB- denotes (
T17383 38508-38510 NN denotes H1
T17382 38496-38507 JJ denotes anti-histon
T17381 38492-38495 CC denotes and
T17380 38490-38491 -COMMA- denotes ,
T17379 38482-38490 JJ denotes anti-p65
T17378 38480-38481 -COMMA- denotes ,
T17377 38471-38480 JJ denotes anti-IκBα
T17376 38469-38470 -COMMA- denotes ,
T17375 38461-38469 JJ denotes anti-A20
T17374 38456-38460 IN denotes with
T17373 38447-38455 VB denotes revealed
T17372 38442-38446 VB denotes were
T17371 38430-38441 NN denotes Immunoblots
T17370 38427-38428 -RRB- denotes )
T17369 38419-38427 NNP denotes Sciences
T17368 38414-38418 NNP denotes Life
T17367 38408-38413 NNP denotes Elmer
T17366 38401-38407 NNP denotes Perkin
T17365 38400-38401 -LRB- denotes (
T17364 38390-38399 NN denotes detection
T17363 38386-38389 NN denotes ECL
T17362 38382-38385 CC denotes and
T17361 38373-38381 NN denotes blotting
T17360 38365-38372 JJ denotes western
T17359 38362-38364 IN denotes by
T17358 38353-38361 VB denotes analyzed
T17357 38349-38352 CC denotes and
T17356 38340-38348 NN denotes SDS-PAGE
T17355 38337-38339 IN denotes by
T17354 38327-38336 VB denotes separated
T17353 38314-38326 RB denotes subsequently
T17352 38309-38313 VB denotes were
T17351 38301-38308 NN denotes lysates
T17350 38297-38300 DT denotes The
T17349 38292-38296 NNP denotes 4°C.
T17348 38289-38291 IN denotes at
T17347 38285-38288 NN denotes min
T17346 38282-38284 CD denotes 15
T17345 38278-38281 IN denotes for
T17344 38276-38277 -RRB- denotes )
T17343 38266-38276 NN denotes inhibitors
T17342 38254-38265 NN denotes phosphatase
T17341 38250-38253 CC denotes and
T17340 38241-38249 NN denotes protease
T17339 38236-38240 IN denotes with
T17338 38223-38235 VB denotes supplemented
T17337 38218-38222 NN denotes EGTA
T17336 38215-38217 NN denotes mM
T17335 38211-38214 CD denotes 0.1
T17334 38207-38210 CC denotes and
T17333 38202-38206 NN denotes EDTA
T17332 38199-38201 NN denotes mM
T16222 35771-35784 VB denotes permeabilized
T16221 35767-35770 CC denotes and
T16220 35761-35766 VB denotes fixed
T16219 35759-35760 -COMMA- denotes ,
T16218 35752-35759 VB denotes stained
T16217 35747-35751 VB denotes were
T16216 35741-35746 NNP denotes Cells
T16215 35738-35740 NN denotes A.
T16214 35728-35737 NNP denotes Brefeldin
T16213 35722-35727 NN denotes µg/ml
T16212 35720-35721 CD denotes 3
T16211 35717-35719 IN denotes of
T16210 35708-35716 NN denotes presence
T16209 35704-35707 DT denotes the
T16208 35701-35703 IN denotes in
T16207 35696-35700 NN denotes lung
T16206 35692-35695 DT denotes the
T16205 35687-35691 IN denotes from
T16204 35678-35686 VB denotes prepared
T16203 35673-35677 VB denotes were
T16202 35661-35672 NN denotes suspensions
T16201 35656-35660 NN denotes cell
T16200 35649-35655 JJ denotes single
T16199 35645-35648 CC denotes and
T16198 35636-35644 VB denotes isolated
T16197 35631-35635 VB denotes were
T16196 35625-35630 NN denotes lungs
T16195 35621-35624 CC denotes and
T16194 35617-35620 NN denotes BAL
T16193 35615-35616 -COMMA- denotes ,
T16192 35610-35615 RB denotes later
T16191 35608-35609 NN denotes h
T16190 35606-35607 CD denotes 6
T16189 35603-35604 -RRB- denotes ]
T16188 35601-35603 CD denotes 86
T16187 35600-35601 -LRB- denotes [
T16186 35590-35599 VB denotes described
T16185 35579-35589 RB denotes previously
T16184 35576-35578 IN denotes as
T16183 35574-35575 -RRB- denotes )
T16182 35569-35574 NN denotes Sigma
T16181 35568-35569 -LRB- denotes (
T16180 35566-35567 NN denotes A
T16179 35556-35565 NN denotes Brefeldin
T16178 35553-35555 NN denotes µg
T16177 35550-35552 CD denotes 50
T16176 35545-35549 IN denotes with
T16175 35532-35544 RB denotes intranasally
T16174 35527-35531 NN denotes mice
T16173 35523-35526 DT denotes the
T16172 35514-35522 VB denotes treating
T16171 35511-35513 IN denotes by
T16170 35500-35510 VB denotes determined
T16169 35495-35499 VB denotes were
T16168 35489-35494 NN denotes cells
T16167 35487-35488 NN denotes T
T16166 35482-35486 JJ denotes CD8+
T16165 35471-35481 VB denotes expressing
T16164 35466-35470 NN denotes IFNγ
T16163 35462-35465 CC denotes and
T16162 35460-35461 -RRB- denotes )
T16161 35457-35460 NN denotes GrB
T16160 35456-35457 -LRB- denotes (
T16159 35454-35455 NN denotes B
T16158 35445-35453 NN denotes Granzyme
T16157 35439-35444 NN denotes cells
T16156 35437-35438 NN denotes T
T16155 35432-35436 JJ denotes CD8+
T16154 35422-35431 VB denotes activated
T16153 35419-35421 IN denotes of
T16152 35410-35418 NN denotes staining
T16151 35405-35409 NN denotes IFNγ
T16150 35401-35404 CC denotes and
T16149 35397-35400 NN denotes GrB
T16148 35383-35396 JJ denotes intracellular
T16147 35378-35382 FW denotes vivo
T16146 35375-35377 FW denotes In
T16611 36347-36354 NN denotes vectors
T16610 36336-36346 NN denotes expression
T16609 36327-36335 JJ denotes specific
T16608 36322-36326 IN denotes with
T16607 36315-36321 NN denotes method
T16606 36302-36314 NN denotes transfection
T16605 36290-36301 VB denotes precipitate
T16604 36280-36289 NN denotes phosphate
T16603 36272-36279 NN denotes calcium
T16602 36268-36271 DT denotes the
T16601 36262-36267 VB denotes using
T16600 36250-36261 VB denotes transfected
T16599 36245-36249 VB denotes were
T16598 36239-36244 NN denotes cells
T16597 36231-36238 NN denotes HEK293T
T16596 36218-36229 NN denotes antibiotics
T16595 36214-36217 CC denotes and
T16594 36205-36213 NN denotes pyruvate
T16593 36198-36204 NN denotes sodium
T16592 36195-36197 NN denotes mM
T16591 36191-36194 CD denotes 0.4
T16590 36189-36190 -COMMA- denotes ,
T16589 36178-36189 NN denotes L-glutamine
T16588 36175-36177 NN denotes mM
T16587 36173-36174 CD denotes 2
T16586 36171-36172 -COMMA- denotes ,
T16585 36168-36171 NN denotes FCS
T16584 36166-36167 NN denotes %
T16583 36164-36166 CD denotes 10
T16582 36159-36163 IN denotes with
T16581 36146-36158 VB denotes supplemented
T16580 36144-36145 -RRB- denotes )
T16579 36139-36144 NN denotes Gibco
T16578 36138-36139 -LRB- denotes (
T16577 36133-36137 NN denotes DMEM
T15854 35368-35372 VB denotes used
T15853 35364-35367 VB denotes was
T15852 35359-35363 NN denotes X-47
T15851 35356-35358 IN denotes of
T15850 35351-35355 NN denotes dose
T15849 35341-35350 JJ denotes sublethal
T15848 35339-35340 DT denotes a
T15847 35334-35338 IN denotes with
T15846 35328-35333 RB denotes twice
T15845 35319-35327 VB denotes infected
T15844 35313-35318 NN denotes mouse
T15843 35311-35312 DT denotes a
T15842 35306-35310 IN denotes from
T15841 35300-35305 NN denotes serum
T15840 35298-35299 -COMMA- denotes ,
T15839 35291-35298 NN denotes control
T15838 35282-35290 JJ denotes positive
T15837 35279-35281 IN denotes as
T15836 35277-35278 -COLON- denotes ;
T15835 35276-35277 -RRB- denotes )
T15834 35272-35276 NN denotes sera
T15833 35269-35271 IN denotes of
T15832 35262-35268 NN denotes effect
T15831 35248-35261 NN denotes agglutination
T15830 35244-35247 IN denotes for
T15829 35236-35243 NN denotes control
T15828 35235-35236 -LRB- denotes (
T15827 35229-35234 NN denotes virus
T15826 35224-35228 NN denotes X-47
T15825 35221-35223 IN denotes of
T15824 35213-35220 RB denotes instead
T15823 35209-35212 NN denotes PR8
T15822 35206-35208 CC denotes or
T15821 35204-35205 -RRB- denotes )
T15820 35197-35204 NN denotes control
T15819 35183-35196 NN denotes agglutination
T15818 35182-35183 -LRB- denotes (
T15817 35176-35181 NN denotes serum
T15816 35169-35175 JJ denotes immune
T15815 35166-35168 IN denotes of
T15814 35158-35165 RB denotes instead
T15813 35154-35157 NNP denotes PBS
T15812 35145-35153 VB denotes included
T15811 35136-35144 NN denotes controls
T15810 35127-35135 JJ denotes Negative
T15809 35120-35125 RB denotes later
T15808 35116-35119 NN denotes min
T15807 35113-35115 CD denotes 30
T15806 35108-35112 VB denotes read
T15805 35103-35107 VB denotes were
T15804 35096-35102 NN denotes titers
T15803 35092-35095 CC denotes and
T15802 35086-35091 VB denotes added
T15801 35082-35085 VB denotes was
T15800 35078-35081 NN denotes RBC
T15799 35070-35077 NN denotes chicken
T15798 35068-35069 NN denotes %
T15797 35065-35068 CD denotes 0.5
T15796 35062-35064 IN denotes of
T15795 35055-35061 NN denotes volume
T15794 35049-35054 JJ denotes equal
T15793 35046-35048 DT denotes an
T15792 35044-35045 -COMMA- denotes ,
T15791 35037-35044 RB denotes Finally
T15790 35029-35035 NN denotes plates
T15789 35020-35028 NN denotes U-bottom
T15788 35012-35019 JJ denotes 96-well
T15787 35009-35011 IN denotes in
T15786 34997-35008 NN denotes temperature
T15785 34992-34996 NN denotes room
T15784 34989-34991 IN denotes at
T15783 34984-34988 NN denotes hour
T15782 34982-34983 CD denotes 1
T15781 34978-34981 IN denotes for
T15780 34972-34977 NN denotes virus
T15779 34967-34971 NN denotes X-47
T15778 34964-34966 IN denotes of
T15777 34958-34963 NN denotes units
T15776 34955-34957 NN denotes HA
T15775 34953-34954 CD denotes 4
T15774 34948-34952 IN denotes with
T15773 34943-34947 NN denotes sera
T15772 34940-34942 IN denotes of
T15771 34933-34939 NN denotes series
T15770 34924-34932 NN denotes dilution
T15769 34915-34923 JJ denotes two-fold
T16269 36065-36070 NN denotes cells
T16268 36060-36064 JJ denotes dead
T16267 36055-36059 IN denotes from
T16266 36050-36054 JJ denotes live
T16265 36037-36049 VB denotes discriminate
T16264 36034-36036 TO denotes to
T16263 36029-36033 VB denotes used
T16262 36025-36028 VB denotes was
T16261 36023-36024 -RRB- denotes )
T16260 36017-36023 NNP denotes Probes
T16259 36007-36016 NNP denotes Molecular
T16258 36006-36007 -LRB- denotes (
T16257 36002-36005 NN denotes kit
T16256 35996-36001 NN denotes stain
T16255 35991-35995 NN denotes cell
T16254 35986-35990 JJ denotes dead
T16253 35981-35985 NN denotes aqua
T16252 35973-35980 JJ denotes fixable
T16251 35963-35972 JJ denotes Live/Dead
T16250 35951-35961 NN denotes expression
T16249 35946-35950 JJ denotes CD8+
T16248 35942-35945 CC denotes and
T16247 35937-35941 JJ denotes CD3+
T16246 35930-35936 JJ denotes CD62lo
T16245 35927-35929 IN denotes on
T16244 35921-35926 VB denotes based
T16243 35911-35920 NN denotes cytometry
T16242 35906-35910 NN denotes flow
T16241 35903-35905 IN denotes by
T16240 35894-35902 VB denotes analyzed
T16239 35889-35893 VB denotes were
T16238 35883-35888 NN denotes cells
T16237 35881-35882 NN denotes T
T16236 35876-35880 JJ denotes CD8+
T16235 35866-35875 VB denotes Activated
T16234 35852-35864 NN denotes instructions
T16233 35849-35851 POS denotes 's
T16232 35837-35849 NN denotes manufacturer
T16231 35833-35836 DT denotes the
T16230 35830-35832 TO denotes to
T16229 35820-35829 VB denotes according
T16228 35818-35819 -RRB- denotes )
T16227 35807-35818 NNP denotes Biosciences
T16226 35804-35806 NNP denotes BD
T16225 35802-35803 -COMMA- denotes ,
T16224 35786-35802 NN denotes Cytofix/Cytoperm
T16223 35785-35786 -LRB- denotes (
T15768 34913-34914 DT denotes a
T15767 34902-34912 VB denotes incubating
T15766 34899-34901 IN denotes by
T15765 34894-34898 VB denotes done
T15764 34890-34893 VB denotes was
T15763 34880-34889 NN denotes Titration
T15762 34875-34878 NN denotes RBC
T15761 34867-34874 NN denotes chicken
T15760 34865-34866 NN denotes %
T15759 34863-34865 CD denotes 50
T15758 34856-34862 NN denotes volume
T15757 34851-34855 CD denotes 1/10
T15756 34846-34850 IN denotes with
T15755 34838-34845 VB denotes cleared
T15754 34833-34837 VB denotes were
T15753 34828-34832 NN denotes sera
T15752 34826-34827 -COMMA- denotes ,
T15751 34818-34826 NN denotes proteins
T15750 34810-34817 NN denotes binding
T15749 34805-34809 NN denotes acid
T15748 34798-34804 JJ denotes sialic
T15747 34791-34797 VB denotes remove
T15746 34788-34790 TO denotes To
T15745 34783-34786 NN denotes min
T15744 34780-34782 CD denotes 30
T15743 34776-34779 IN denotes for
T15462 34363-34364 -RRB- denotes ]
T15461 34361-34363 CD denotes 85
T15460 34360-34361 -LRB- denotes [
T15459 34353-34359 NNP denotes Muench
T15458 34349-34352 CC denotes and
T15457 34344-34348 NNP denotes Reed
T15456 34341-34343 IN denotes of
T15455 34334-34340 NN denotes method
T15454 34330-34333 DT denotes the
T15453 34327-34329 TO denotes to
T15452 34317-34326 VB denotes according
T15451 34306-34316 VB denotes calculated
T15450 34301-34305 RB denotes then
T15449 34296-34300 VB denotes were
T15448 34289-34295 NN denotes titers
T15447 34282-34288 NN denotes TCID50
T15446 34271-34280 VB denotes monitored
T15445 34267-34270 VB denotes was
T15444 34250-34266 NN denotes hemagglutination
T15443 34247-34249 IN denotes of
T15442 34238-34246 NN denotes dilution
T15441 34228-34237 JJ denotes end-point
T15440 34224-34227 CC denotes and
T15439 34218-34223 VB denotes added
T15438 34213-34217 VB denotes were
T15437 34211-34212 -RRB- denotes )
T15436 34208-34211 NN denotes RBC
T15435 34207-34208 -LRB- denotes (
T15434 34201-34206 NN denotes cells
T15433 34195-34200 NN denotes blood
T15432 34191-34194 JJ denotes red
T15431 34183-34190 NN denotes chicken
T15430 34181-34182 NN denotes %
T15429 34178-34181 CD denotes 0.5
T15428 34176-34177 -COMMA- denotes ,
T15427 34168-34176 NN denotes read-out
T15426 34164-34167 IN denotes For
T15425 34151-34162 NN denotes antibiotics
T15424 34147-34150 CC denotes and
T15423 34138-34146 NN denotes pyruvate
T15422 34131-34137 NN denotes sodium
T15421 34128-34130 NN denotes mM
T15420 34124-34127 CD denotes 0.4
T15419 34122-34123 -COMMA- denotes ,
T15418 34111-34122 NN denotes L-glutamine
T15417 34108-34110 NN denotes mM
T15416 34106-34107 CD denotes 2
T15415 34104-34105 -COMMA- denotes ,
T15414 34103-34104 -RRB- denotes )
T15413 34098-34103 NN denotes µg/ml
T15412 34096-34097 CD denotes 1
T15411 34095-34096 -LRB- denotes (
T15410 34087-34094 NN denotes trypsin
T15409 34082-34086 IN denotes with
T15408 34069-34081 VB denotes supplemented
T15407 34064-34068 NN denotes DMEM
T15406 34061-34063 IN denotes in
T15405 34056-34060 NN denotes days
T15404 34054-34055 CD denotes 5
T15403 34050-34053 IN denotes for
T15402 34044-34049 NN denotes cells
T15401 34039-34043 NN denotes MDCK
T15400 34036-34038 IN denotes on
T15399 34026-34035 VB denotes incubated
T15398 34021-34025 VB denotes were
T15397 34009-34020 NN denotes homogenates
T15396 34004-34008 NN denotes lung
T15395 34001-34003 IN denotes of
T15394 33991-34000 NN denotes dilutions
T15393 33984-33990 JJ denotes serial
T15392 33973-33983 JJ denotes Eight-fold
T15391 33968-33971 NNP denotes PBS
T15390 33965-33967 IN denotes in
T15389 33963-33964 -RRB- denotes )
T15388 33953-33963 NN denotes Kinematica
T15387 33952-33953 -LRB- denotes (
T15386 33940-33951 NN denotes homogenizer
T15385 33931-33939 NN denotes Polytron
T15384 33929-33930 DT denotes a
T15383 33924-33928 IN denotes with
T15382 33912-33923 VB denotes homogenized
T15381 33907-33911 VB denotes were
T15380 33901-33906 NN denotes lungs
T15379 33899-33900 -COLON- denotes :
T15378 33892-33899 VB denotes follows
T15377 33889-33891 IN denotes as
T15376 33880-33888 VB denotes measured
T15375 33876-33879 VB denotes was
T15374 33874-33875 -RRB- denotes )
T15373 33868-33874 NN denotes TCID50
T15372 33867-33868 -LRB- denotes (
T15371 33862-33866 NN denotes dose
T15370 33851-33861 JJ denotes infectious
T15369 33843-33850 NN denotes culture
T15368 33836-33842 NN denotes tissue
T15367 33829-33835 JJ denotes median
T15366 33827-33828 -COMMA- denotes ,
T15365 33821-33827 NN denotes titers
T15364 33815-33820 JJ denotes viral
T15363 33805-33814 JJ denotes pulmonary
T15362 33795-33804 VB denotes determine
T15361 33792-33794 TO denotes To
T15360 33786-33790 NN denotes X-47
T15330 33611-33616 NN denotes mg/kg
T15329 33608-33610 CD denotes 12
T15328 33607-33608 -LRB- denotes (
T15327 33598-33606 NN denotes ketamine
T15326 33593-33597 IN denotes with
T15325 33583-33592 NN denotes injection
T15324 33578-33582 JJ denotes i.p.
T15323 33575-33577 IN denotes by
T15322 33562-33574 VB denotes anesthetized
T15321 33557-33561 VB denotes were
T15320 33552-33556 NN denotes mice
T15319 33550-33551 -COMMA- denotes ,
T15318 33539-33550 NN denotes inoculation
T15317 33533-33538 JJ denotes viral
T15316 33529-33532 IN denotes For
T15315 33522-33527 NN denotes cells
T15314 33517-33521 NN denotes MDCK
T15313 33514-33516 IN denotes in
T15312 33503-33513 VB denotes propagated
T15311 33499-33502 VB denotes was
T15310 33497-33498 -RRB- denotes )
T15309 33478-33497 NN denotes PR8×A/Victoria/3/75
T15308 33476-33477 -COLON- denotes ;
T15307 33472-33476 NN denotes H3N2
T15306 33471-33472 -LRB- denotes (
T15305 33466-33470 NN denotes X-47
T15304 33462-33465 NN denotes IAV
T15303 33454-33461 VB denotes adapted
T15302 33448-33453 NN denotes Mouse
T15301 33441-33447 NN denotes titers
T15300 33435-33440 JJ denotes viral
T15299 33432-33434 IN denotes of
T15298 33418-33431 NN denotes determination
T15297 33414-33417 CC denotes and
T15296 33404-33413 NN denotes infection
T15295 33398-33403 JJ denotes Viral
T15742 34771-34775 NN denotes 56°C
T15741 34768-34770 TO denotes to
T15740 34760-34767 NN denotes heating
T15739 34756-34759 CC denotes and
T15738 34752-34755 NNP denotes PBS
T15737 34749-34751 IN denotes in
T15736 34741-34748 NN denotes citrate
T15735 34734-34740 NN denotes sodium
T15734 34732-34733 NN denotes %
T15733 34728-34732 CD denotes 0.75
T15732 34725-34727 IN denotes of
T15731 34716-34724 NN denotes addition
T15730 34713-34715 IN denotes by
T15729 34701-34712 VB denotes inactivated
T15728 34697-34700 VB denotes was
T15727 34693-34696 NN denotes RDE
T15726 34689-34692 DT denotes the
T15725 34687-34688 -COMMA- denotes ,
T15724 34683-34687 NN denotes 37°C
T15723 34680-34682 IN denotes at
T15722 34670-34679 RB denotes overnight
T15721 34659-34669 NN denotes incubation
T15720 34653-34658 IN denotes After
T15719 34638-34651 NN denotes agglutination
T15718 34635-34637 IN denotes of
T15717 34624-34634 NN denotes inhibition
T15716 34614-34623 JJ denotes aspecific
T15715 34611-34613 IN denotes of
T15714 34603-34610 JJ denotes capable
T15713 34594-34602 NN denotes proteins
T15712 34588-34593 NN denotes serum
T15711 34583-34587 IN denotes from
T15710 34577-34582 NN denotes acids
T15709 34570-34576 JJ denotes sialic
T15708 34563-34569 VB denotes remove
T15707 34560-34562 TO denotes to
T15706 34558-34559 -RRB- denotes )
T15705 34553-34558 NNP denotes Sigma
T15704 34551-34552 -COLON- denotes ;
T15703 34543-34551 NN denotes filtrate
T15702 34531-34542 NN denotes RDE/Cholera
T15701 34530-34531 -LRB- denotes (
T15700 34523-34529 NN denotes enzyme
T15699 34503-34522 JJ denotes receptor-destroying
T15698 34498-34502 IN denotes with
T15697 34490-34497 VB denotes treated
T15696 34485-34489 VB denotes were
T15695 34479-34484 DT denotes these
T15694 34476-34478 IN denotes of
T15693 34471-34475 NN denotes sera
T15692 34469-34470 -COMMA- denotes ,
T15691 34465-34469 NN denotes mice
T15690 34456-34464 JJ denotes infected
T15689 34453-34455 IN denotes in
T15688 34446-34452 NN denotes titers
T15687 34442-34445 NN denotes HAI
T15686 34438-34441 DT denotes the
T15685 34428-34437 VB denotes determine
T15684 34425-34427 TO denotes To
T15683 34418-34424 NN denotes titers
T15682 34416-34417 -RRB- denotes )
T15681 34406-34416 NN denotes inhibition
T15680 34389-34405 NN denotes hemagglutination
T15679 34388-34389 -LRB- denotes (
T15678 34384-34387 NN denotes HAI
T15677 34381-34383 IN denotes of
T15676 34367-34380 NN denotes Determination
T15116 33383-33395 RB denotes respectively
T15115 33381-33382 -RRB- denotes )
T15068 33058-33071 JJ denotes pathogen-free
T15067 33049-33057 JJ denotes specific
T15066 33046-33048 IN denotes in
T15065 33037-33045 NNP denotes Research
T15064 33026-33036 NNP denotes Biomedical
T15063 33016-33025 NNP denotes Molecular
T15062 33013-33015 IN denotes of
T15061 33002-33012 NNP denotes Department
T15060 32998-33001 NNP denotes VIB
T15059 32994-32997 DT denotes the
T15058 32991-32993 IN denotes at
T15057 32985-32990 NN denotes cages
T15056 32974-32984 VB denotes ventilated
T15055 32961-32973 RB denotes individually
T15054 32958-32960 IN denotes in
T15053 32951-32957 VB denotes housed
T15052 32946-32950 VB denotes were
T15051 32941-32945 NN denotes Mice
T15050 32938-32939 -RRB- denotes ]
T15049 32936-32938 CD denotes 48
T15048 32935-32936 -LRB- denotes [
T15047 32925-32934 RB denotes elsewhere
T15046 32918-32924 NN denotes detail
T15045 32915-32917 IN denotes in
T15044 32905-32914 VB denotes described
T15043 32901-32904 VB denotes are
T15042 32897-32900 CC denotes and
T15041 32886-32896 NN denotes transgenes
T15040 32878-32885 NN denotes LysMCre
T15039 32869-32877 NN denotes A20fl/fl
T15038 32860-32868 VB denotes generate
T15037 32857-32859 TO denotes to
T15036 32855-32856 -RRB- denotes )
T15035 32848-32855 NNP denotes Germany
T15034 32846-32847 -COMMA- denotes ,
T15033 32839-32846 NNP denotes Cologne
T15032 32836-32838 IN denotes of
T15031 32825-32835 NNP denotes University
T15030 32823-32824 -COMMA- denotes ,
T15029 32815-32823 NNP denotes Genetics
T15028 32812-32814 IN denotes of
T15027 32802-32811 NNP denotes Institute
T15026 32800-32801 -COMMA- denotes ,
T15025 32793-32800 NNP denotes Förster
T15024 32790-32792 NNP denotes I.
T15023 32787-32789 IN denotes by
T15021 32777-32778 -LRB- denotes (
T15020 32775-32776 -RRB- denotes ]
T15019 32773-32775 CD denotes 84
T15018 32772-32773 -LRB- denotes [
T15017 32767-32771 NN denotes mice
T15016 32758-32766 JJ denotes LysM-Cre
T15015 32753-32757 IN denotes with
T15014 32745-32752 VB denotes crossed
T15013 32740-32744 VB denotes were
T15012 32735-32739 NN denotes mice
T15011 32726-32734 NN denotes A20fl/fl
T15010 32723-32724 -RRB- denotes ]
T15009 32721-32723 CD denotes 56
T15008 32720-32721 -LRB- denotes [
T15007 32710-32719 VB denotes described
T15006 32699-32709 RB denotes previously
T15005 32696-32698 IN denotes as
T15004 32686-32695 VB denotes generated
T15003 32681-32685 VB denotes were
T15002 32676-32680 NN denotes mice
T15001 32667-32675 NN denotes A20fl/fl
T15000 32662-32666 NN denotes Mice
T14889 32658-32659 -RRB- denotes )
T14888 32653-32658 NN denotes mg/kg
T14887 32650-32652 CD denotes 60
T14886 32649-32650 -LRB- denotes (
T14885 32640-32648 NN denotes xylazine
T14884 32636-32639 CC denotes and
T14883 32634-32635 -RRB- denotes )
T14882 32629-32634 NN denotes mg/kg
T14881 32626-32628 CD denotes 12
T14880 32625-32626 -LRB- denotes (
T14879 32616-32624 NN denotes ketamine
T15359 33776-33785 CD denotes 0.05-LD50
T15358 33773-33775 CC denotes or
T15357 33766-33772 NN denotes 2-LD50
T15356 33753-33765 RB denotes respectively
T15355 33744-33752 VB denotes received
T15354 33739-33743 NN denotes mice
T15353 33737-33738 -COMMA- denotes ,
T15352 33728-33737 NN denotes infection
T15351 33718-33727 JJ denotes sublethal
T15350 33714-33717 CC denotes and
T15349 33707-33713 JJ denotes lethal
T15348 33703-33706 IN denotes For
T15347 33689-33701 RB denotes intranasally
T15346 33676-33688 VB denotes administered
T15345 33672-33675 VB denotes was
T15344 33668-33671 NNP denotes PBS
T15343 33665-33667 IN denotes in
T15342 33657-33664 VB denotes diluted
T15341 33652-33656 NN denotes X-47
T15340 33649-33651 NN denotes µl
T15339 33646-33648 CD denotes 50
T15338 33642-33645 CC denotes and
T15337 33640-33641 -RRB- denotes )
T15336 33635-33640 NN denotes mg/kg
T15335 33632-33634 CD denotes 60
T15334 33631-33632 -LRB- denotes (
T15333 33622-33630 NN denotes xylazine
T15332 33618-33621 CC denotes and
T15331 33616-33617 -RRB- denotes )
T14878 32613-32615 IN denotes of
T14877 32605-32612 NN denotes mixture
T14876 32603-32604 DT denotes a
T14875 32600-32602 IN denotes of
T14874 32590-32599 NN denotes injection
T14873 32588-32589 -RRB- denotes )
T14872 32584-32588 JJ denotes i.p.
T14871 32583-32584 -LRB- denotes (
T14870 32567-32582 JJ denotes intraperitoneal
T14869 32564-32566 IN denotes by
T14868 32551-32563 VB denotes anesthetized
T14867 32546-32550 VB denotes were
T14866 32541-32545 NN denotes Mice
T14865 32532-32539 NN denotes animals
T14864 32529-32531 IN denotes of
T14863 32519-32528 NN denotes suffering
T14862 32508-32518 VB denotes ameliorate
T14861 32505-32507 TO denotes to
T14860 32500-32504 VB denotes made
T14859 32495-32499 VB denotes were
T14858 32487-32494 NN denotes efforts
T14857 32483-32486 DT denotes All
T14856 32480-32481 -RRB- denotes )
T14855 32472-32480 CD denotes 2010/001
T14854 32469-32471 NN denotes ID
T14853 32460-32468 NN denotes approval
T14842 32393-32396 DT denotes the
T14841 32390-32392 IN denotes by
T14840 32381-32389 VB denotes approved
T14839 32376-32380 VB denotes were
T14838 32366-32375 NN denotes protocols
T14837 32359-32365 NN denotes Animal
T14836 32346-32357 NN denotes regulations
T14835 32339-32345 NN denotes animal
T14834 32337-32338 -RRB- denotes )
T14833 32327-32337 NN denotes 86/609/EEG
T14832 32325-32326 -COMMA- denotes ,
T14831 32315-32325 NN denotes 2010/63/EU
T14830 32304-32314 NN denotes Directives
T14829 32301-32303 NN denotes EU
T14828 32300-32301 -LRB- denotes (
T14827 32291-32299 JJ denotes European
T14826 32287-32290 CC denotes and
T14825 32285-32286 -RRB- denotes )
T14824 32275-32285 CD denotes 06/04/2010
T14823 32268-32274 NNP denotes Decree
T14822 32262-32267 NNP denotes Royal
T14821 32254-32261 NNP denotes Belgian
T14820 32252-32253 -COMMA- denotes ,
T14819 32242-32252 CD denotes 22/12/2003
T14818 32238-32241 CC denotes and
T14817 32227-32237 CD denotes 14/08/1986
T14816 32223-32226 NN denotes Law
T14815 32215-32222 JJ denotes Belgian
T14814 32214-32215 -LRB- denotes (
T14813 32205-32213 JJ denotes national
T14812 32201-32204 DT denotes the
T14811 32198-32200 TO denotes to
T14810 32188-32197 VB denotes according
T14809 32178-32187 VB denotes conducted
T14808 32173-32177 VB denotes were
T14807 32168-32172 NN denotes mice
T14806 32165-32167 IN denotes on
T14805 32153-32164 NN denotes experiments
T14804 32149-32152 DT denotes All
T14803 32139-32148 NN denotes statement
T14802 32132-32138 NN denotes Ethics
T15114 33371-33381 NN denotes A20myel-WT
T15113 33370-33371 -LRB- denotes (
T15112 33365-33369 NN denotes type
T15111 33360-33364 JJ denotes wild
T15110 33356-33359 CC denotes and
T15109 33345-33355 NN denotes A20myel-KO
T15108 33338-33344 VB denotes termed
T15107 33333-33337 VB denotes were
T15106 33323-33332 NN denotes transgene
T15105 33314-33322 NN denotes LysM-Cre
T15104 33310-33313 DT denotes the
T15103 33302-33309 VB denotes lacking
T15102 33299-33301 CC denotes or
T15101 33288-33298 VB denotes expressing
T15100 33283-33287 NN denotes mice
T15099 33274-33282 NN denotes A20fl/fl
T15098 33262-33272 NN denotes background
T15097 33254-33261 NN denotes C57Bl/6
T15096 33250-33253 DT denotes the
T15095 33247-33249 TO denotes to
T15094 33241-33246 NN denotes times
T15093 33235-33240 CD denotes three
T15092 33223-33234 VB denotes backcrossed
T15091 33218-33222 VB denotes were
T15090 33210-33217 NN denotes animals
T15089 33201-33209 NN denotes LysM-Cre
T15088 33192-33200 NN denotes A20fl/fl
T15087 33179-33190 NN denotes littermates
T15086 33167-33178 JJ denotes sex-matched
T15085 33163-33166 CC denotes and
T15084 33161-33162 -RRB- denotes )
T15083 33158-33161 JJ denotes old
T15082 33152-33157 NN denotes weeks
T15081 33150-33151 CD denotes 9
T15080 33146-33149 CC denotes and
T15079 33144-33145 CD denotes 7
T15078 33136-33143 IN denotes between
T15077 33135-33136 -LRB- denotes (
T15076 33130-33134 NN denotes age-
T15075 33127-33129 IN denotes on
T15074 33117-33126 VB denotes performed
T15073 33112-33116 VB denotes were
T15072 33101-33111 NN denotes infections
T15071 33091-33100 NNP denotes Influenza
T15070 33079-33089 NN denotes facilities
T15069 33072-33078 NN denotes animal
T14852 32458-32459 -COMMA- denotes ,
T14851 32449-32458 NN denotes LA1400091
T14850 32442-32448 NN denotes number
T14849 32435-32441 NN denotes permit
T14848 32434-32435 -LRB- denotes (
T14847 32423-32433 NNP denotes University
T14846 32417-32422 NNP denotes Ghent
T14845 32414-32416 IN denotes of
T14844 32404-32413 NN denotes committee
T14843 32397-32403 NN denotes ethics
T12945 31044-31047 DT denotes the
T12944 31040-31043 CC denotes and
T12943 31032-31039 JJ denotes elderly
T12942 31028-31031 DT denotes the
T12941 31026-31027 -COMMA- denotes ,
T12940 31019-31026 NN denotes infants
T12939 31016-31018 IN denotes in
T12938 31003-31015 RB denotes particularly
T12937 31001-31002 -COMMA- denotes ,
T12936 30992-31001 NN denotes mortality
T12935 30988-30991 CC denotes and
T12934 30978-30987 NN denotes morbidity
T12933 30973-30977 JJ denotes high
T12932 30970-30972 TO denotes to
T12931 30962-30969 VB denotes leading
T12930 30960-30961 -COMMA- denotes ,
T12929 30952-30960 RB denotes annually
T12928 30948-30951 NN denotes IAV
T12927 30945-30947 IN denotes by
T12926 30936-30944 VB denotes infected
T12925 30933-30935 VB denotes is
T12924 30922-30932 NN denotes population
T12923 30919-30921 POS denotes 's
T12922 30914-30919 NN denotes world
T12921 30911-30913 IN denotes of
T12920 30905-30910 NN denotes fifth
T12919 30903-30904 DT denotes a
T12918 30897-30902 IN denotes About
T12917 30886-30895 NN denotes therapies
T12916 30880-30885 JJ denotes novel
T12915 30873-30879 IN denotes toward
T12914 30868-30872 NN denotes step
T12913 30858-30867 JJ denotes important
T12912 30855-30857 DT denotes an
T12911 30852-30854 VB denotes is
T12910 30842-30851 NN denotes responses
T12909 30835-30841 JJ denotes immune
T12908 30825-30834 JJ denotes antiviral
T12907 30818-30824 JJ denotes innate
T12906 30815-30817 IN denotes of
T12905 30804-30814 NN denotes activation
T12904 30800-30803 DT denotes the
T12903 30788-30799 VB denotes controlling
T12902 30784-30787 CC denotes and
T12901 30770-30783 VB denotes Understanding
T12900 30756-30768 VB denotes investigated
T12899 30753-30755 VB denotes be
T12898 30750-30752 TO denotes to
T12897 30742-30749 VB denotes remains
T12896 30740-30741 -COMMA- denotes ,
T12895 30735-30740 NN denotes cells
T12894 30724-30734 JJ denotes epithelial
T12893 30719-30723 NN denotes lung
T12892 30716-30718 IN denotes as
T12891 30711-30715 JJ denotes such
T12890 30709-30710 -COMMA- denotes ,
T12889 30706-30709 NN denotes IAV
T12888 30703-30705 TO denotes to
T12887 30694-30702 NN denotes response
T12886 30690-30693 DT denotes the
T12885 30687-30689 IN denotes in
T12884 30676-30686 VB denotes implicated
T12883 30672-30675 VB denotes are
T12882 30667-30671 WDT denotes that
T12881 30661-30666 NN denotes types
T12880 30656-30660 NN denotes cell
T12879 30650-30655 JJ denotes other
T12878 30647-30649 IN denotes in
T12877 30642-30646 NN denotes role
T12876 30628-30641 JJ denotes non-redundant
T12875 30620-30627 JJ denotes similar
T12874 30618-30619 DT denotes a
T12873 30614-30617 VB denotes has
T12872 30610-30613 NN denotes A20
T12871 30607-30609 IN denotes If
T12870 30595-30605 NN denotes conditions
T12869 30581-30594 JJ denotes physiological
T12868 30575-30580 IN denotes under
T12867 30564-30574 NN denotes deficiency
T12866 30560-30563 NN denotes A20
T12865 30556-30559 IN denotes for
T12864 30545-30555 VB denotes substitute
T12863 30541-30544 RB denotes not
T12862 30538-30541 MD denotes can
T12861 30533-30537 NN denotes DUBs
T12860 30527-30532 JJ denotes other
T12859 30522-30526 IN denotes that
T12858 30518-30521 CC denotes and
T12857 30508-30517 NN denotes infection
T12856 30504-30507 NN denotes IAV
T12855 30501-30503 TO denotes to
T12854 30492-30500 NN denotes response
T12853 30489-30491 IN denotes in
T12852 30479-30488 NN denotes signaling
T12851 30471-30478 VB denotes induced
T12850 30465-30470 NN denotes RIG-I
T12849 30462-30464 IN denotes of
T12848 30451-30461 NN denotes gatekeeper
T12847 30443-30450 JJ denotes central
T12846 30441-30442 DT denotes a
T12845 30438-30440 VB denotes is
T12844 30432-30437 NN denotes cells
T12843 30424-30431 JJ denotes myeloid
T12842 30421-30423 IN denotes in
T12841 30410-30420 NN denotes expression
T12840 30406-30409 NN denotes A20
T12839 30401-30405 IN denotes that
T12838 30391-30400 VB denotes indicates
T12837 30382-30390 VB denotes describe
T12836 30377-30381 RB denotes here
T12835 30374-30376 PRP denotes we
T12834 30369-30373 IN denotes that
T12833 30364-30368 NN denotes mice
T12832 30353-30363 NN denotes A20myel-KO
T12831 30350-30352 IN denotes of
T12830 30340-30349 NN denotes phenotype
T12829 30329-30339 JJ denotes protective
T12828 30323-30328 JJ denotes clear
T12827 30319-30322 DT denotes The
T12826 30307-30317 NN denotes conditions
T12825 30289-30306 JJ denotes non-physiological
T12824 30283-30288 IN denotes under
T12823 30274-30282 VB denotes obtained
T12822 30270-30273 VB denotes was
T12821 30266-30269 CC denotes and
T12820 30261-30265 NN denotes data
T12819 30255-30260 FW denotes vitro
T12818 30252-30254 FW denotes in
T12817 30249-30251 TO denotes to
T12816 30241-30248 VB denotes limited
T12815 30237-30240 VB denotes was
T12814 30233-30236 RB denotes far
T12813 30230-30232 RB denotes so
T12812 30221-30229 NN denotes evidence
T12811 30219-30220 -COMMA- denotes ,
T12810 30212-30219 RB denotes However
T12809 30200-30210 NN denotes redundancy
T12808 30191-30199 JJ denotes possible
T12807 30179-30190 VB denotes implicating
T12806 30177-30178 -COMMA- denotes ,
T12805 30172-30177 NN denotes IRF-3
T12804 30168-30171 CC denotes and
T12803 30162-30167 NN denotes NF-κB
T12802 30159-30161 TO denotes to
T12801 30149-30158 NN denotes signaling
T12800 30143-30148 NN denotes RIG-I
T12799 30134-30142 VB denotes regulate
T12798 30123-30133 RB denotes negatively
T12797 30120-30122 TO denotes to
T12796 30114-30119 VB denotes shown
T12795 30109-30113 VB denotes been
T12794 30104-30108 VB denotes have
T12793 30102-30103 -RRB- denotes ]
T12792 30100-30102 CD denotes 52
T12791 30099-30100 -LRB- denotes [
T12790 30098-30099 CD denotes –
T12789 30097-30098 -RRB- denotes ]
T12788 30095-30097 CD denotes 49
T12787 30094-30095 -LRB- denotes [
T12786 30090-30093 NN denotes A20
T12785 30086-30089 CC denotes and
T12784 30084-30085 -COMMA- denotes ,
T12783 30083-30084 -RRB- denotes ]
T12782 30081-30083 CD denotes 31
T12781 30080-30081 -LRB- denotes [
T12780 30072-30079 CD denotes OTUB1/2
T12779 30070-30071 -COMMA- denotes ,
T12778 30069-30070 -RRB- denotes ]
T12777 30067-30069 CD denotes 30
T12776 30066-30067 -LRB- denotes [
T12775 30064-30065 -COMMA- denotes ,
T12774 30063-30064 -RRB- denotes ]
T12773 30061-30063 CD denotes 29
T12772 30060-30061 -LRB- denotes [
T12771 30055-30059 NN denotes CYLD
T12770 30053-30054 -COMMA- denotes ,
T12769 30052-30053 -RRB- denotes ]
T12768 30050-30052 CD denotes 28
T12767 30049-30050 -LRB- denotes [
T12766 30044-30048 NNP denotes DUBA
T12765 30041-30043 IN denotes as
T12764 30036-30040 JJ denotes such
T12763 30034-30035 -COMMA- denotes ,
T12762 30033-30034 -RRB- denotes )
T12761 30029-30033 NN denotes DUBs
T12760 30028-30029 -LRB- denotes (
T12759 30020-30027 NN denotes enzymes
T12758 30003-30019 VB denotes deubiquitinating
T12757 29997-30002 JJ denotes other
T12756 29988-29996 JJ denotes Multiple
T12755 29976-29986 NN denotes laboratory
T12754 29972-29975 PRP-DOLLAR- denotes our
T12753 29969-29971 IN denotes in
T12752 29954-29968 NN denotes investigations
T12751 29947-29953 JJ denotes future
T12750 29944-29946 IN denotes of
T12749 29938-29943 NN denotes topic
T12748 29934-29937 DT denotes the
T12747 29931-29933 VB denotes be
T12746 29926-29930 MD denotes will
T12745 29915-29925 NN denotes substrates
T12744 29909-29914 DT denotes these
T12743 29906-29908 IN denotes of
T12742 29891-29905 NN denotes identification
T12741 29887-29890 DT denotes The
T12740 29880-29885 NN denotes cells
T12739 29872-29879 JJ denotes myeloid
T12738 29869-29871 IN denotes in
T12737 29858-29868 NN denotes activation
T12736 29853-29857 NN denotes IRF3
T12735 29849-29852 CC denotes and
T12734 29843-29848 NN denotes NF-κB
T12733 29835-29842 VB denotes mediate
T12732 29830-29834 WDT denotes that
T12731 29819-29829 NN denotes substrates
T12730 29813-29818 JJ denotes other
T12629 29201-29208 NN denotes context
T12628 29196-29200 DT denotes this
T12627 29193-29195 IN denotes In
T12626 29190-29191 -RRB- denotes ]
T12625 29188-29190 CD denotes 80
T12624 29187-29188 -LRB- denotes [
T12623 29178-29186 NN denotes proteins
T12622 29168-29177 NN denotes signaling
T12621 29158-29167 JJ denotes different
T12620 29155-29157 IN denotes of
T12619 29148-29154 NN denotes status
T12618 29133-29147 NN denotes ubiquitination
T12617 29129-29132 DT denotes the
T12616 29118-29128 VB denotes modulating
T12615 29115-29117 IN denotes by
T12614 29105-29114 NN denotes functions
T12613 29094-29104 JJ denotes inhibitory
T12612 29089-29093 NN denotes IRF3
T12611 29085-29088 CC denotes and
T12610 29079-29084 NN denotes NF-κB
T12609 29075-29078 PRP-DOLLAR- denotes its
T12608 29069-29074 VB denotes exert
T12607 29066-29068 TO denotes to
T12606 29057-29065 VB denotes believed
T12605 29054-29056 VB denotes is
T12604 29050-29053 NN denotes A20
T12603 29038-29048 NN denotes expression
T12602 29033-29037 NN denotes gene
T12601 29017-29032 JJ denotes proinflammatory
T12600 29014-29016 TO denotes to
T12599 29003-29013 VB denotes contribute
T12598 28999-29002 MD denotes may
T12597 28994-28998 WDT denotes that
T12596 28985-28993 NN denotes pathways
T12595 28975-28984 NN denotes signaling
T12594 28969-28974 JJ denotes other
T12593 28966-28968 IN denotes on
T12592 28962-28965 NN denotes A20
T12591 28959-28961 IN denotes of
T12590 28952-28958 NN denotes effect
T12589 28941-28951 JJ denotes additional
T12588 28938-28940 DT denotes an
T12587 28930-28937 VB denotes exclude
T12586 28926-28929 RB denotes not
T12585 28921-28925 VB denotes does
T12584 28916-28920 DT denotes this
T12583 28914-28915 -COMMA- denotes ,
T12582 28907-28914 RB denotes However
T12581 28900-28905 NN denotes genes
T12580 28894-28899 DT denotes these
T12579 28882-28893 VB denotes controlling
T12578 28873-28881 NN denotes pathways
T12577 28867-28872 JJ denotes major
T12576 28863-28866 DT denotes the
T12575 28859-28862 VB denotes are
T12574 28853-28858 WDT denotes which
T12573 28851-28852 -COMMA- denotes ,
T12572 28841-28851 NN denotes activation
T12571 28836-28840 NN denotes IRF3
T12570 28832-28835 CC denotes and
T12569 28826-28831 NN denotes NF-κB
T12568 28815-28825 VB denotes regulating
T12567 28804-28814 RB denotes negatively
T12566 28801-28803 IN denotes by
T12565 28799-28800 -RRB- denotes )
T12564 28795-28799 NN denotes IFNβ
T12563 28791-28794 CC denotes and
T12562 28789-28790 -COMMA- denotes ,
T12561 28784-28789 NN denotes MIP-2
T12560 28782-28783 -COMMA- denotes ,
T12559 28780-28782 NN denotes KC
T12558 28778-28779 -COMMA- denotes ,
T12557 28774-28778 NN denotes IL-6
T12556 28772-28773 -COMMA- denotes ,
T12555 28769-28772 NN denotes TNF
T12554 28765-28768 IN denotes for
T12553 28754-28764 NN denotes manuscript
T12552 28750-28753 PRP-DOLLAR- denotes our
T12551 28747-28749 IN denotes in
T12550 28741-28746 VB denotes shown
T12549 28738-28740 IN denotes as
T12548 28737-28738 -LRB- denotes (
T12547 28726-28736 NN denotes expression
T12546 28721-28725 NN denotes gene
T12545 28705-28720 JJ denotes proinflammatory
T12544 28693-28704 JJ denotes IAV-induced
T12543 28684-28692 VB denotes inhibits
T12542 28680-28683 NN denotes A20
T12541 28675-28679 IN denotes that
T12540 28667-28674 VB denotes propose
T12539 28664-28666 PRP denotes We
T12538 28653-28662 NN denotes signaling
T12537 28647-28652 NN denotes RIG-I
T12536 28638-28646 VB denotes enhanced
T12535 28629-28637 VB denotes reflects
T12534 28619-28628 NN denotes infection
T12533 28614-28618 NN denotes lung
T12532 28610-28613 NN denotes IAV
T12531 28607-28609 TO denotes to
T12530 28602-28606 NN denotes mice
T12529 28591-28601 NN denotes A20myel-KO
T12528 28588-28590 IN denotes of
T12527 28579-28587 NN denotes response
T12526 28572-28578 JJ denotes immune
T12525 28562-28571 VB denotes increased
T12524 28558-28561 DT denotes the
T12523 28553-28557 IN denotes that
T12522 28542-28552 VB denotes suggesting
T12521 28540-28541 -COMMA- denotes ,
T12520 28539-28540 -RRB- denotes ]
T12519 28537-28539 CD denotes 13
T12518 28536-28537 -LRB- denotes [
T12517 28532-28535 NN denotes IAV
T12516 28529-28531 TO denotes to
T12515 28520-28528 NN denotes response
T12514 28513-28519 JJ denotes immune
T12513 28506-28512 JJ denotes innate
T12512 28502-28505 DT denotes the
T12511 28499-28501 IN denotes in
T12510 28494-28498 NN denotes role
T12509 28490-28493 JJ denotes key
T12508 28488-28489 DT denotes a
T12507 28483-28487 VB denotes play
T12506 28480-28482 TO denotes to
T12505 28474-28479 VB denotes shown
T12504 28469-28473 VB denotes been
T12503 28458-28468 RB denotes previously
T12502 28454-28457 VB denotes has
T12501 28448-28453 NN denotes RIG-I
T12500 28443-28446 NN denotes RNA
T12499 28434-28442 JJ denotes stranded
T12498 28427-28433 JJ denotes double
T12497 28423-28426 NN denotes LMW
T12496 28413-28422 JJ denotes synthetic
T12495 28410-28412 IN denotes by
T12494 28398-28409 NN denotes stimulation
T12493 28392-28397 NN denotes RIG-I
T12492 28389-28391 TO denotes to
T12491 28380-28388 NN denotes response
T12490 28377-28379 IN denotes in
T12489 28366-28376 NN denotes activation
T12488 28361-28365 NN denotes IRF3
T12487 28357-28360 CC denotes and
T12486 28351-28356 NN denotes NF-κB
T12485 28342-28350 VB denotes enhanced
T12484 28334-28341 NN denotes display
T12483 28329-28333 NN denotes BMDM
T12482 28319-28328 JJ denotes deficient
T12481 28315-28318 NN denotes A20
T12480 28310-28314 IN denotes that
T12479 28305-28309 VB denotes show
T12478 28302-28304 PRP denotes We
T12477 28299-28300 -RRB- denotes ]
T12476 28297-28299 CD denotes 78
T12475 28296-28297 -LRB- denotes [
T12474 28286-28295 NN denotes lethality
T12473 28282-28285 CC denotes and
T12472 28266-28281 NN denotes immunopathology
T12471 28251-28265 JJ denotes IAV-associated
T12470 28248-28250 TO denotes to
T12469 28235-28247 NN denotes contributors
T12468 28229-28234 JJ denotes major
T12467 28225-28228 VB denotes are
T12466 28213-28224 NN denotes neutrophils
T12465 28209-28212 RB denotes not
T12464 28205-28208 CC denotes and
T12463 28195-28204 NN denotes monocytes
T12462 28190-28194 IN denotes that
T12461 28185-28189 NN denotes idea
T12460 28181-28184 DT denotes the
T12459 28173-28180 VB denotes support
T12458 28165-28172 RB denotes further
T12457 28163-28164 -COMMA- denotes ,
T12456 28152-28163 NN denotes recruitment
T12455 28150-28151 -RRB- denotes )
T12454 28144-28150 NN denotes CD11b+
T12453 28138-28143 JJ denotes Ly6C+
T12452 28137-28138 -LRB- denotes (
T12451 28128-28136 NN denotes monocyte
T12450 28115-28127 JJ denotes inflammatory
T12449 28106-28114 VB denotes altering
T12448 28098-28105 IN denotes without
T12447 28096-28097 -COMMA- denotes ,
T12446 28085-28096 NN denotes recruitment
T12445 28074-28084 NN denotes neutrophil
T12444 28071-28073 IN denotes on
T12443 28060-28070 NN denotes deficiency
T12442 28056-28059 NN denotes A20
T12441 28053-28055 IN denotes of
T12440 28046-28052 NN denotes effect
T13110 32095-32106 NN denotes coronavirus
T13109 32090-32094 NN denotes SARS
T13108 32086-32089 CC denotes and
T13107 32082-32085 NN denotes RSV
T13106 32072-32081 VB denotes including
T13105 32061-32071 NN denotes infections
T13104 32055-32060 JJ denotes viral
T13103 32049-32054 JJ denotes other
T13102 32041-32048 IN denotes against
T13101 32034-32040 NN denotes battle
T13100 32030-32033 DT denotes the
T13099 32027-32029 IN denotes in
T13098 32018-32026 NN denotes interest
T13097 32015-32017 IN denotes of
T13096 32012-32014 VB denotes be
T13095 32006-32011 MD denotes might
T13094 32002-32005 NN denotes A20
T13093 31999-32001 IN denotes of
T13092 31989-31998 NN denotes targeting
T13091 31981-31988 JJ denotes similar
T13090 31979-31980 -COMMA- denotes ,
T13089 31972-31979 RB denotes Finally
T13088 31959-31970 NN denotes alternative
T13087 31947-31958 JJ denotes interesting
T13086 31944-31946 DT denotes an
T13085 31941-31943 VB denotes be
T13084 31935-31940 MD denotes might
T13083 31931-31934 NN denotes A20
T13082 31928-31930 IN denotes of
T13081 31917-31927 NN denotes inhibitors
T13080 31908-31916 NN denotes compound
T13079 31902-31907 JJ denotes small
T13078 31897-31901 RB denotes Also
T13077 31887-31895 NN denotes approach
T13076 31875-31886 JJ denotes therapeutic
T13075 31869-31874 JJ denotes valid
T13074 31867-31868 DT denotes a
T13073 31864-31866 VB denotes be
T13072 31858-31863 MD denotes might
T13071 31854-31857 NN denotes A20
T13070 31846-31853 IN denotes against
T13069 31840-31845 NN denotes siRNA
T13068 31837-31839 IN denotes of
T13067 31822-31836 NN denotes administration
T13066 31811-31821 JJ denotes intranasal
T13065 31808-31810 IN denotes by
T13064 31799-31807 NN denotes response
T13063 31792-31798 JJ denotes immune
T13062 31782-31791 JJ denotes antiviral
T13061 31778-31781 DT denotes the
T13060 31769-31777 VB denotes boosting
T13059 31765-31768 CC denotes but
T13058 31763-31764 -COMMA- denotes ,
T13057 31753-31763 NN denotes components
T13056 31749-31752 NN denotes IAV
T13055 31739-31748 VB denotes targeting
T13054 31733-31738 NN denotes siRNA
T13053 31728-31732 RB denotes only
T13052 31724-31727 RB denotes not
T13051 31719-31723 IN denotes that
T13050 31711-31718 VB denotes suggest
T13049 31703-31710 NN denotes results
T13048 31699-31702 PRP-DOLLAR- denotes Our
T13047 31696-31697 -RRB- denotes ]
T13046 31694-31696 CD denotes 83
T13045 31693-31694 -LRB- denotes [
T13044 31684-31692 NN denotes optimism
T13043 31680-31683 CC denotes and
T13042 31672-31679 NN denotes success
T13041 31660-31671 JJ denotes significant
T13040 31648-31659 VB denotes experienced
T13039 31644-31647 VB denotes has
T13038 31642-31643 -COMMA- denotes ,
T13037 31637-31642 NN denotes virus
T13036 31627-31636 NN denotes influenza
T13035 31624-31626 TO denotes to
T13034 31616-31623 VB denotes limited
T13033 31612-31615 RB denotes not
T13032 31608-31611 CC denotes but
T13031 31606-31607 -COMMA- denotes ,
T13030 31597-31606 VB denotes including
T13029 31589-31596 NN denotes viruses
T13028 31577-31588 JJ denotes respiratory
T13027 31569-31576 IN denotes against
T13026 31563-31568 NN denotes siRNA
T13025 31560-31562 IN denotes of
T13024 31548-31559 NN denotes application
T13023 31537-31547 JJ denotes intranasal
T13022 31535-31536 -COMMA- denotes ,
T13021 31528-31535 JJ denotes general
T13020 31525-31527 IN denotes in
T13019 31520-31524 NN denotes RNAi
T13018 31517-31519 IN denotes of
T13017 31504-31516 NN denotes applications
T13016 31495-31503 JJ denotes clinical
T13015 31491-31494 DT denotes the
T13014 31488-31490 IN denotes in
T13013 31476-31487 NN denotes bottlenecks
T13012 31470-31475 JJ denotes major
T13011 31463-31469 VB denotes remain
T13010 31454-31462 NN denotes delivery
T13009 31447-31453 NN denotes tissue
T13008 31443-31446 CC denotes and
T13007 31431-31442 NN denotes specificity
T13006 31422-31430 IN denotes Although
T13005 31409-31420 NN denotes replication
T13004 31403-31408 NN denotes virus
T13003 31393-31402 NN denotes influenza
T13002 31390-31392 IN denotes of
T13001 31379-31389 NN denotes inhibitors
T13000 31372-31378 JJ denotes potent
T12999 31369-31371 IN denotes as
T12998 31360-31368 VB denotes function
T12997 31357-31359 TO denotes to
T12996 31351-31356 VB denotes shown
T12995 31346-31350 VB denotes been
T12994 31341-31345 VB denotes have
T12993 31334-31340 NN denotes siRNAs
T12992 31325-31333 VB denotes designed
T12991 31316-31324 RB denotes Properly
T12990 31307-31314 NN denotes regimen
T12989 31297-31306 JJ denotes antiviral
T12988 31290-31296 JJ denotes potent
T12987 31288-31289 DT denotes a
T12986 31285-31287 IN denotes as
T12985 31277-31284 VB denotes evolved
T12984 31269-31276 RB denotes rapidly
T12983 31265-31268 VB denotes has
T12982 31263-31264 -COMMA- denotes ,
T12981 31262-31263 -RRB- denotes )
T12980 31257-31262 NN denotes siRNA
T12979 31256-31257 -LRB- denotes (
T12978 31252-31255 NN denotes RNA
T12977 31240-31251 VB denotes interfering
T12976 31234-31239 JJ denotes short
T12975 31224-31233 JJ denotes synthetic
T12974 31221-31223 IN denotes by
T12973 31211-31220 VB denotes triggered
T12972 31209-31210 -COMMA- denotes ,
T12971 31197-31209 NN denotes interference
T12970 31193-31196 NN denotes RNA
T12969 31191-31192 -COMMA- denotes ,
T12968 31186-31191 NN denotes years
T12967 31179-31185 JJ denotes recent
T12966 31176-31178 IN denotes In
T12965 31168-31174 NN denotes battle
T12964 31161-31167 VB denotes ending
T12963 31155-31160 RB denotes never
T12962 31153-31154 DT denotes a
T12961 31148-31152 IN denotes into
T12960 31141-31147 NN denotes design
T12959 31131-31140 JJ denotes antiviral
T12958 31127-31130 CC denotes and
T12957 31119-31126 NN denotes vaccine
T12956 31116-31118 IN denotes of
T12955 31107-31115 NN denotes attempts
T12954 31103-31106 DT denotes all
T12953 31097-31102 VB denotes turns
T12952 31093-31096 NN denotes IAV
T12951 31090-31092 IN denotes of
T12950 31085-31089 NN denotes rate
T12949 31076-31084 NN denotes mutation
T12948 31071-31075 JJ denotes high
T12947 31067-31070 DT denotes The
T12946 31048-31065 JJ denotes immunocompromised
T12439 28036-28045 JJ denotes selective
T12438 28032-28035 DT denotes the
T12437 28030-28031 -COMMA- denotes ,
T12436 28023-28030 RB denotes However
T12435 28020-28021 -RRB- denotes ]
T12434 28018-28020 CD denotes 79
T12433 28017-28018 -LRB- denotes [
T12432 28015-28016 -COMMA- denotes ,
T12431 28014-28015 -RRB- denotes ]
T12430 28012-28014 CD denotes 64
T12429 28011-28012 -LRB- denotes [
T12428 28001-28010 NN denotes lethality
T12427 27991-28000 VB denotes increased
T12426 27986-27990 IN denotes with
T12425 27975-27985 VB denotes associated
T12424 27972-27974 VB denotes be
T12423 27969-27971 TO denotes to
T12422 27960-27968 VB denotes believed
T12421 27950-27959 RB denotes generally
T12420 27947-27949 VB denotes is
T12419 27941-27946 NN denotes cells
T12418 27928-27940 JJ denotes inflammatory
T12417 27925-27927 IN denotes of
T12416 27918-27924 NN denotes influx
T12415 27908-27917 JJ denotes excessive
T12414 27905-27907 DT denotes an
T12327 27369-27370 -LRB- denotes [
T12326 27359-27368 NN denotes infection
T12325 27355-27358 NN denotes IAV
T12324 27348-27354 IN denotes during
T12323 27337-27347 NN denotes production
T12322 27331-27336 NN denotes MCP-1
T12321 27328-27330 IN denotes of
T12320 27321-27327 NN denotes source
T12319 27313-27320 JJ denotes primary
T12318 27309-27312 DT denotes the
T12317 27305-27308 VB denotes are
T12316 27299-27304 NN denotes cells
T12315 27288-27298 JJ denotes epithelial
T12314 27281-27287 NN denotes airway
T12313 27276-27280 IN denotes that
T12312 27269-27275 NN denotes notion
T12311 27265-27268 DT denotes the
T12310 27260-27264 IN denotes with
T12309 27249-27259 JJ denotes consistent
T12308 27246-27248 VB denotes is
T12307 27240-27245 WDT denotes which
T12306 27238-27239 -COMMA- denotes ,
T12305 27233-27238 NN denotes cells
T12304 27225-27232 JJ denotes myeloid
T12303 27222-27224 IN denotes in
T12302 27218-27221 NN denotes A20
T12301 27215-27217 IN denotes of
T12300 27207-27214 NN denotes absence
T12299 27203-27206 DT denotes the
T12298 27200-27202 IN denotes by
T12297 27191-27199 VB denotes affected
T12296 27187-27190 RB denotes not
T12295 27182-27186 VB denotes were
T12294 27175-27181 NN denotes levels
T12293 27169-27174 NN denotes MCP-1
T12292 27166-27167 -RRB- denotes ]
T12291 27164-27166 CD denotes 72
T12290 27163-27164 -LRB- denotes [
T12289 27161-27162 -COMMA- denotes ,
T12288 27160-27161 -RRB- denotes ]
T12287 27158-27160 CD denotes 71
T12286 27157-27158 -LRB- denotes [
T12285 27147-27156 NN denotes infection
T12284 27143-27146 NN denotes IAV
T12283 27136-27142 IN denotes during
T12282 27130-27135 NN denotes cells
T12281 27124-27129 DT denotes these
T12280 27121-27123 IN denotes of
T12279 27112-27120 NN denotes function
T12278 27101-27111 JJ denotes protective
T12277 27099-27100 DT denotes a
T12276 27090-27098 VB denotes supports
T12275 27081-27089 NN denotes evidence
T12274 27074-27080 JJ denotes recent
T12273 27072-27073 -COMMA- denotes ,
T12272 27066-27072 NN denotes debate
T12271 27060-27065 IN denotes under
T12270 27054-27059 RB denotes still
T12269 27051-27053 VB denotes is
T12268 27041-27050 NN denotes infection
T12267 27035-27040 JJ denotes viral
T12266 27028-27034 IN denotes during
T12265 27016-27027 NN denotes neutrophils
T12264 27013-27015 IN denotes of
T12263 27008-27012 NN denotes role
T12262 27004-27007 DT denotes the
T12261 26995-27003 IN denotes Although
T12260 26984-26993 NN denotes infection
T12259 26977-26983 IN denotes during
T12258 26974-26976 IN denotes on
T12257 26968-26973 RB denotes later
T12256 26958-26967 NN denotes clearance
T12255 26952-26957 JJ denotes viral
T12254 26943-26951 VB denotes improved
T12253 26940-26942 IN denotes in
T12252 26931-26939 VB denotes resulted
T12251 26927-26930 CC denotes and
T12250 26925-26926 -COMMA- denotes ,
T12249 26914-26925 NN denotes compartment
T12248 26898-26913 JJ denotes bronchoalveolar
T12247 26894-26897 DT denotes the
T12246 26891-26893 TO denotes to
T12245 26879-26890 NN denotes recruitment
T12244 26868-26878 NN denotes neutrophil
T12243 26865-26867 IN denotes of
T12242 26853-26864 NN denotes enhancement
T12241 26843-26852 JJ denotes selective
T12240 26841-26842 DT denotes a
T12239 26836-26840 IN denotes with
T12238 26825-26835 VB denotes associated
T12237 26821-26824 VB denotes was
T12236 26816-26820 DT denotes This
T12235 26810-26814 NN denotes mice
T12234 26805-26809 NN denotes type
T12233 26800-26804 JJ denotes wild
T12232 26797-26799 TO denotes to
T12231 26788-26796 VB denotes compared
T12230 26783-26787 NN denotes mice
T12229 26772-26782 NN denotes A20myel-KO
T12228 26769-26771 IN denotes of
T12227 26763-26768 NN denotes lungs
T12226 26759-26762 DT denotes the
T12225 26756-26758 IN denotes in
T12224 26750-26755 NN denotes IL-1β
T12223 26746-26749 CC denotes and
T12222 26742-26745 NN denotes TNF
T12221 26740-26741 -COMMA- denotes ,
T12220 26736-26740 NN denotes IL-6
T12219 26733-26735 IN denotes as
T12218 26728-26732 JJ denotes such
T12217 26718-26727 NN denotes cytokines
T12216 26702-26717 JJ denotes proinflammatory
T12215 26694-26701 JJ denotes several
T12214 26690-26693 CC denotes and
T12213 26684-26689 NN denotes MIP-2
T12212 26680-26683 CC denotes and
T12211 26677-26679 NN denotes KC
T12210 26674-26676 IN denotes as
T12209 26669-26673 JJ denotes such
T12208 26658-26668 NN denotes chemokines
T12207 26647-26657 VB denotes attracting
T12206 26636-26646 NN denotes neutrophil
T12205 26626-26635 RB denotes primarily
T12204 26623-26625 IN denotes of
T12203 26616-26622 NN denotes levels
T12202 26609-26615 JJ denotes higher
T12201 26606-26608 IN denotes in
T12200 26597-26605 VB denotes resulted
T12199 26593-26596 NN denotes IAV
T12198 26588-26592 IN denotes with
T12197 26578-26587 NN denotes infection
T12196 26573-26577 FW denotes vivo
T12195 26570-26572 FW denotes in
T12194 26568-26569 -COMMA- denotes ,
T12193 26559-26568 RB denotes Similarly
T12192 26548-26557 NN denotes infection
T12191 26542-26547 FW denotes vitro
T12190 26539-26541 FW denotes in
T12189 26536-26538 TO denotes to
T12188 26527-26535 NN denotes response
T12187 26524-26526 IN denotes in
T12186 26519-26523 NN denotes mice
T12185 26514-26518 NN denotes type
T12184 26509-26513 JJ denotes wild
T12183 26506-26508 TO denotes to
T12182 26497-26505 VB denotes compared
T12181 26492-26496 NN denotes IFNs
T12180 26490-26491 CD denotes I
T12179 26485-26489 NN denotes type
T12178 26481-26484 CC denotes and
T12177 26471-26480 NN denotes cytokines
T12176 26469-26470 -COMMA- denotes ,
T12175 26459-26469 NN denotes chemokines
T12174 26456-26458 IN denotes of
T12173 26448-26455 NN denotes amounts
T12172 26441-26447 JJ denotes higher
T12171 26433-26440 VB denotes express
T12170 26428-26432 NN denotes mice
T12169 26417-26427 NN denotes A20myel-KO
T12168 26412-26416 IN denotes from
T12167 26404-26411 VB denotes derived
T12166 26392-26403 NN denotes macrophages
T12165 26383-26391 JJ denotes alveolar
T12164 26380-26382 CC denotes or
T12163 26375-26379 NN denotes BMDM
T12162 26370-26374 IN denotes that
T12161 26365-26369 VB denotes show
T12160 26359-26364 MD denotes could
T12159 26356-26358 PRP denotes We
T12158 26345-26354 NN denotes clearance
T12157 26339-26344 JJ denotes viral
T12156 26336-26338 TO denotes to
T12155 26323-26335 VB denotes contributing
T12154 26315-26322 RB denotes further
T12153 26313-26314 -COMMA- denotes ,
T12152 26304-26313 NN denotes particles
T12151 26298-26303 JJ denotes viral
T12150 26291-26297 VB denotes coated
T12149 26282-26290 NN denotes antibody
T12148 26278-26281 CC denotes and
T12147 26272-26277 NN denotes cells
T12146 26262-26271 JJ denotes apoptotic
T12145 26253-26261 JJ denotes infected
T12144 26247-26252 NN denotes virus
T12143 26235-26246 VB denotes phagocytose
T12142 26232-26234 TO denotes to
T12141 26226-26231 VB denotes known
T12140 26221-26225 RB denotes also
T12139 26217-26220 VB denotes are
T12138 26205-26216 NN denotes macrophages
T12729 29805-29812 VB denotes targets
T12728 29800-29804 RB denotes also
T12727 29796-29799 NN denotes A20
T12726 29791-29795 IN denotes that
T12725 29783-29790 RB denotes however
T12724 29774-29782 VB denotes excluded
T12723 29771-29773 VB denotes be
T12722 29767-29770 RB denotes not
T12721 29764-29767 MD denotes can
T12720 29761-29763 PRP denotes It
T12719 29753-29759 NN denotes status
T12718 29738-29752 NN denotes ubiquitination
T12717 29732-29737 PRP-DOLLAR- denotes their
T12716 29729-29731 IN denotes on
T12715 29718-29728 NN denotes deficiency
T12714 29714-29717 NN denotes A20
T12713 29711-29713 IN denotes of
T12712 29704-29710 NN denotes effect
T12711 29700-29703 DT denotes the
T12710 29691-29699 VB denotes studying
T12709 29686-29690 IN denotes from
T12708 29683-29685 PRP denotes us
T12707 29672-29682 VB denotes preventing
T12706 29670-29671 -COMMA- denotes ,
T12705 29659-29670 NN denotes macrophages
T12704 29651-29658 JJ denotes primary
T12703 29648-29650 IN denotes in
T12702 29643-29647 NN denotes IKKε
T12701 29639-29642 CC denotes and
T12700 29634-29638 NN denotes TBK1
T12699 29631-29633 IN denotes of
T12698 29616-29630 NN denotes ubiquitination
T12697 29609-29615 VB denotes detect
T12696 29601-29608 RB denotes clearly
T12695 29598-29600 TO denotes to
T12694 29591-29597 JJ denotes unable
T12693 29586-29590 VB denotes were
T12692 29583-29585 PRP denotes we
T12691 29579-29582 RB denotes far
T12690 29576-29578 RB denotes So
T12689 29567-29574 JJ denotes unclear
T12688 29561-29566 RB denotes still
T12687 29558-29560 VB denotes is
T12686 29547-29557 NN denotes activation
T12685 29541-29546 NN denotes NF-κB
T12684 29533-29540 VB denotes induced
T12683 29527-29532 NN denotes RIG-I
T12682 29524-29526 IN denotes of
T12681 29513-29523 NN denotes regulation
T12680 29509-29512 DT denotes the
T12679 29506-29508 IN denotes in
T12678 29497-29505 VB denotes involved
T12677 29493-29496 VB denotes are
T12676 29482-29492 NN denotes mechanisms
T12675 29474-29481 JJ denotes similar
T12674 29466-29473 IN denotes Whether
T12673 29463-29464 -RRB- denotes ]
T12672 29461-29463 CD denotes 82
T12671 29460-29461 -LRB- denotes [
T12670 29458-29459 -COMMA- denotes ,
T12669 29457-29458 -RRB- denotes ]
T12668 29455-29457 CD denotes 81
T12667 29454-29455 -LRB- denotes [
T12666 29449-29453 NN denotes IRF3
T12665 29440-29448 NN denotes activity
T12664 29437-29439 TO denotes to
T12663 29429-29436 NN denotes ability
T12662 29423-29428 PRP-DOLLAR- denotes their
T12661 29419-29422 CC denotes and
T12660 29417-29418 -COMMA- denotes ,
T12659 29413-29417 NN denotes IKKε
T12658 29409-29412 CC denotes and
T12657 29404-29408 NN denotes TBK1
T12656 29401-29403 IN denotes of
T12655 29378-29400 NN denotes K63-polyubiquitination
T12654 29368-29377 VB denotes affecting
T12653 29357-29367 RB denotes negatively
T12652 29349-29356 RB denotes thereby
T12651 29347-29348 -COMMA- denotes ,
T12650 29340-29347 NN denotes complex
T12649 29324-29339 NN denotes TRAF3-TBK1-IKKε
T12648 29320-29323 DT denotes the
T12647 29312-29319 VB denotes disrupt
T12646 29309-29311 TO denotes to
T12645 29306-29308 TO denotes to
T12644 29300-29305 NN denotes ABIN1
T12643 29296-29299 CC denotes and
T12642 29288-29295 NN denotes TAX1BP1
T12641 29279-29287 NN denotes proteins
T12640 29261-29278 JJ denotes ubiquitin-binding
T12639 29257-29260 DT denotes the
T12638 29252-29256 IN denotes with
T12637 29241-29251 VB denotes cooperates
T12636 29237-29240 NN denotes A20
T12635 29232-29236 IN denotes that
T12634 29226-29231 VB denotes shown
T12633 29217-29225 RB denotes recently
T12632 29213-29216 VB denotes was
T12631 29210-29212 PRP denotes it
T12630 29208-29209 -COMMA- denotes ,
T12137 26196-26204 JJ denotes Alveolar
T12136 26193-26194 -RRB- denotes ]
T12135 26191-26193 CD denotes 70
T12134 26190-26191 -LRB- denotes [
T12133 26185-26189 NN denotes IFNs
T12132 26183-26184 CD denotes I
T12131 26178-26182 NN denotes type
T12130 26175-26177 IN denotes of
T12129 26165-26174 NN denotes producers
T12128 26157-26164 JJ denotes primary
T12127 26153-26156 DT denotes the
T12126 26149-26152 VB denotes are
T12125 26144-26148 PRP denotes they
T12124 26140-26143 CC denotes and
T12123 26138-26139 -COMMA- denotes ,
T12122 26137-26138 -RRB- denotes ]
T12121 26135-26137 CD denotes 69
T12120 26134-26135 -LRB- denotes [
T12119 26124-26133 NN denotes infection
T12118 26121-26123 IN denotes of
T12117 26115-26120 NN denotes phase
T12116 26107-26114 JJ denotes primary
T12115 26103-26106 DT denotes the
T12114 26096-26102 IN denotes during
T12113 26091-26095 NN denotes lung
T12112 26087-26090 DT denotes the
T12413 27901-27904 CC denotes and
T12412 27892-27900 NN denotes response
T12411 27883-27891 NN denotes cytokine
T12410 27867-27882 JJ denotes proinflammatory
T12409 27857-27866 JJ denotes excessive
T12408 27854-27856 DT denotes an
T12407 27848-27853 IN denotes since
T12406 27837-27847 JJ denotes surprising
T12405 27830-27836 RB denotes rather
T12404 27827-27829 VB denotes is
T12403 27821-27826 WDT denotes which
T12402 27819-27820 -COMMA- denotes ,
T12401 27810-27819 NN denotes infection
T12400 27806-27809 NN denotes IAV
T12399 27799-27805 JJ denotes lethal
T12398 27797-27798 DT denotes a
T12397 27789-27796 IN denotes against
T12396 27779-27788 VB denotes protected
T12395 27774-27778 VB denotes were
T12394 27769-27773 NN denotes mice
T12393 27758-27768 NN denotes A20myel-KO
T12392 27755-27756 -RRB- denotes ]
T12391 27753-27755 CD denotes 78
T12390 27752-27753 -LRB- denotes [
T12389 27736-27751 NN denotes immunopathology
T12388 27724-27735 JJ denotes IAV-induced
T12387 27721-27723 TO denotes to
T12386 27708-27720 NN denotes contributors
T12385 27702-27707 JJ denotes major
T12384 27691-27701 VB denotes considered
T12383 27687-27690 VB denotes are
T12382 27683-27686 CC denotes and
T12381 27681-27682 -RRB- denotes ]
T12380 27679-27681 CD denotes 77
T12379 27678-27679 -LRB- denotes [
T12378 27666-27677 NN denotes macrophages
T12377 27650-27665 JJ denotes proinflammatory
T12376 27647-27649 CC denotes or
T12375 27641-27646 NN denotes cells
T12374 27631-27640 JJ denotes dendritic
T12373 27618-27630 JJ denotes inflammatory
T12372 27613-27617 IN denotes into
T12371 27605-27612 VB denotes develop
T12370 27595-27604 NN denotes monocytes
T12369 27589-27594 DT denotes these
T12368 27579-27588 NN denotes infection
T12367 27575-27578 NN denotes IAV
T12366 27568-27574 IN denotes During
T12365 27565-27566 -RRB- denotes ]
T12364 27563-27565 CD denotes 76
T12363 27562-27563 -LRB- denotes [
T12362 27561-27562 CD denotes –
T12361 27560-27561 -RRB- denotes ]
T12360 27558-27560 CD denotes 74
T12359 27557-27558 -LRB- denotes [
T12358 27541-27556 NN denotes immunopathology
T12357 27538-27540 IN denotes of
T12356 27532-27537 NN denotes signs
T12355 27524-27531 VB denotes reduced
T12354 27516-27523 NN denotes display
T12353 27512-27515 CC denotes and
T12352 27502-27511 NN denotes infection
T12351 27498-27501 NN denotes IAV
T12350 27490-27497 IN denotes against
T12349 27480-27489 VB denotes protected
T12348 27476-27479 VB denotes are
T12347 27474-27475 -COMMA- denotes ,
T12346 27465-27474 NN denotes monocytes
T12345 27453-27464 VB denotes circulating
T12344 27450-27452 IN denotes of
T12343 27443-27449 NN denotes subset
T12342 27441-27442 DT denotes a
T12341 27438-27440 IN denotes on
T12340 27428-27437 VB denotes expressed
T12339 27425-27427 VB denotes is
T12338 27419-27424 WDT denotes which
T12337 27417-27418 -COMMA- denotes ,
T12336 27413-27417 NN denotes CCR2
T12335 27404-27412 NN denotes receptor
T12334 27398-27403 NN denotes MCP-1
T12333 27394-27397 DT denotes the
T12332 27390-27393 IN denotes for
T12331 27380-27389 JJ denotes deficient
T12330 27375-27379 NN denotes Mice
T12329 27372-27373 -RRB- denotes ]
T12328 27370-27372 CD denotes 73
T12111 26084-26086 TO denotes to
T12110 26078-26083 NN denotes cells
T12109 26071-26077 JJ denotes immune
T12108 26064-26070 JJ denotes innate
T12107 26056-26063 VB denotes attract
T12106 26051-26055 WDT denotes that
T12105 26040-26050 NN denotes chemokines
T12104 26036-26039 CC denotes and
T12103 26026-26035 NN denotes cytokines
T12102 26010-26025 JJ denotes proinflammatory
T12101 26007-26009 IN denotes of
T12100 26000-26006 NN denotes source
T12099 25990-25999 JJ denotes important
T12098 25987-25989 DT denotes an
T12097 25983-25986 VB denotes are
T12096 25978-25982 PRP denotes They
T12095 25975-25976 -RRB- denotes ]
T12094 25973-25975 CD denotes 68
T12093 25972-25973 -LRB- denotes [
T12092 25970-25971 -COMMA- denotes ,
T12091 25969-25970 -RRB- denotes ]
T12090 25967-25969 CD denotes 67
T12089 25966-25967 -LRB- denotes [
T12088 25956-25965 NN denotes particles
T12087 25952-25955 NN denotes IAV
T12086 25941-25951 JJ denotes infectious
T12085 25931-25940 VB denotes encounter
T12084 25926-25930 WDT denotes that
T12083 25920-25925 NN denotes cells
T12082 25914-25919 JJ denotes first
T12081 25910-25913 DT denotes the
T12080 25907-25909 IN denotes of
T12079 25903-25906 CD denotes one
T12078 25899-25902 VB denotes are
T12077 25894-25898 PRP denotes they
T12076 25891-25893 IN denotes as
T12075 25887-25890 NN denotes IAV
T12074 25879-25886 IN denotes against
T12073 25870-25878 NN denotes response
T12072 25863-25869 JJ denotes immune
T12071 25856-25862 JJ denotes innate
T12070 25852-25855 DT denotes the
T12069 25849-25851 IN denotes in
T12068 25841-25848 JJ denotes crucial
T12067 25836-25840 RB denotes also
T12066 25832-25835 VB denotes are
T12065 25820-25831 NN denotes macrophages
T12064 25811-25819 JJ denotes alveolar
T12063 25809-25810 -COMMA- denotes ,
T12062 25802-25809 RB denotes However
T12061 25799-25800 -RRB- denotes ]
T12060 25797-25799 CD denotes 66
T12059 25796-25797 -LRB- denotes [
T12058 25794-25795 -COMMA- denotes ,
T12057 25793-25794 -RRB- denotes ]
T12056 25791-25793 CD denotes 65
T12055 25790-25791 -LRB- denotes [
T12054 25780-25789 NN denotes functions
T12053 25763-25779 JJ denotes immunomodulatory
T12052 25753-25762 JJ denotes important
T12051 25747-25752 VB denotes exert
T12050 25735-25746 NN denotes macrophages
T12049 25726-25734 JJ denotes alveolar
T12048 25724-25725 -COMMA- denotes ,
T12047 25714-25724 NN denotes conditions
T9996 24597-24606 NN denotes infection
T9995 24593-24596 NN denotes IAV
T9994 24586-24592 JJ denotes lethal
T9993 24584-24585 DT denotes a
T9992 24576-24583 IN denotes against
T9991 24565-24575 NN denotes protection
T9990 24561-24564 CC denotes and
T9989 24552-24560 NN denotes response
T9988 24545-24551 JJ denotes immune
T9987 24538-24544 JJ denotes innate
T9986 24528-24537 VB denotes increased
T9985 24525-24527 DT denotes an
T9984 24520-24524 IN denotes with
T9983 24509-24519 VB denotes associated
T9982 24506-24508 VB denotes is
T9981 24500-24505 NN denotes cells
T9980 24492-24499 JJ denotes myeloid
T9979 24489-24491 IN denotes in
T9885 23960-23963 CC denotes and
T9884 23956-23959 NN denotes TNF
T9883 23954-23955 -COMMA- denotes ,
T9882 23950-23954 NN denotes IL-6
T9881 23940-23949 NN denotes cytokines
T9880 23924-23939 JJ denotes proinflammatory
T9879 23920-23923 DT denotes the
T9878 23917-23919 IN denotes of
T9877 23910-23916 NN denotes levels
T9876 23905-23909 RB denotes Also
T9875 23902-23903 -RRB- denotes )
T9874 23900-23902 NN denotes 4C
T9873 23893-23899 NN denotes figure
T9872 23892-23893 -LRB- denotes (
T9871 23887-23891 NN denotes mice
T9870 23881-23886 DT denotes these
T9869 23878-23880 IN denotes of
T9868 23872-23877 NN denotes lungs
T9867 23868-23871 DT denotes the
T9866 23865-23867 IN denotes in
T9865 23853-23864 NN denotes neutrophils
T9864 23850-23852 IN denotes of
T9863 23842-23849 NN denotes numbers
T9862 23832-23841 VB denotes increased
T9861 23828-23831 DT denotes the
T9860 23823-23827 IN denotes with
T9859 23812-23822 VB denotes correlates
T9858 23806-23811 WDT denotes which
T9857 23804-23805 -COMMA- denotes ,
T9856 23803-23804 -RRB- denotes )
T9855 23801-23803 NN denotes 4C
T9854 23794-23800 NN denotes figure
T9853 23793-23794 -LRB- denotes (
T9852 23783-23792 NN denotes infection
T9851 23779-23782 NN denotes IAV
T9850 23772-23778 JJ denotes lethal
T9849 23762-23771 VB denotes following
T9848 23757-23761 NN denotes mice
T9847 23752-23756 NN denotes type
T9846 23747-23751 JJ denotes wild
T9845 23744-23746 TO denotes to
T9844 23735-23743 VB denotes compared
T9843 23727-23734 NN denotes animals
T9842 23716-23726 NN denotes A20myel-KO
T9841 23713-23715 IN denotes in
T9840 23704-23712 JJ denotes stronger
T9839 23700-23703 VB denotes was
T9838 23689-23699 NN denotes production
T9837 23683-23688 NN denotes MIP-2
T9836 23679-23682 CC denotes and
T9835 23676-23678 NN denotes KC
T9834 23666-23675 JJ denotes pulmonary
T9833 23664-23665 -COMMA- denotes ,
T9832 23655-23664 NN denotes infection
T9831 23651-23654 NN denotes IAV
T9830 23641-23650 JJ denotes sublethal
T9829 23636-23640 IN denotes with
T9828 23623-23635 NN denotes observations
T9827 23619-23622 PRP-DOLLAR- denotes our
T9826 23616-23618 TO denotes to
T9825 23608-23615 JJ denotes Similar
T9824 23605-23606 -RRB- denotes )
T9823 23603-23605 NN denotes 4B
T9822 23596-23602 NN denotes figure
T9821 23595-23596 -LRB- denotes (
T9820 23585-23594 VB denotes succumbed
T9819 23580-23584 WDT denotes that
T9818 23575-23579 NN denotes mice
T9817 23570-23574 NN denotes type
T9816 23565-23569 JJ denotes wild
T9815 23562-23564 TO denotes to
T9814 23553-23561 NN denotes contrast
T9813 23550-23552 IN denotes in
T9812 23548-23549 -COMMA- denotes ,
T9811 23541-23548 VB denotes recover
T9810 23538-23540 TO denotes to
T9809 23533-23537 JJ denotes able
T9808 23528-23532 VB denotes were
T9807 23524-23527 CC denotes but
T9806 23514-23523 NN denotes infection
T9805 23511-23513 IN denotes of
T9804 23504-23510 NN denotes course
T9803 23500-23503 DT denotes the
T9802 23493-23499 IN denotes during
T9801 23491-23492 -RRB- denotes )
T9800 23486-23491 VB denotes shown
T9799 23482-23485 RB denotes not
T9798 23477-23481 NN denotes data
T9797 23475-23476 -COLON- denotes ;
T9796 23472-23475 NN denotes BAL
T9795 23468-23471 DT denotes the
T9794 23465-23467 IN denotes in
T9793 23451-23464 NN denotes concentration
T9792 23443-23450 NN denotes protein
T9791 23437-23442 JJ denotes total
T9790 23427-23436 VB denotes increased
T9789 23424-23426 IN denotes by
T9788 23414-23423 VB denotes reflected
T9787 23411-23413 IN denotes as
T9786 23410-23411 -LRB- denotes (
T9785 23403-23409 NN denotes damage
T9784 23398-23402 NN denotes lung
T9783 23394-23397 CC denotes and
T9782 23389-23393 NN denotes loss
T9781 23382-23388 NN denotes weight
T9780 23370-23381 JJ denotes significant
T9779 23363-23369 VB denotes showed
T9778 23357-23362 RB denotes still
T9777 23352-23356 NN denotes mice
T9776 23341-23351 NN denotes A20myel-KO
T9775 23338-23339 -RRB- denotes )
T9774 23336-23338 NN denotes 4A
T9773 23329-23335 NN denotes figure
T9772 23328-23329 -LRB- denotes (
T9771 23318-23327 NN denotes infection
T9770 23312-23317 IN denotes after
T9769 23307-23311 NN denotes days
T9768 23304-23306 CD denotes 16
T9767 23297-23303 IN denotes within
T9766 23295-23296 -RRB- denotes )
T9765 23291-23295 CD denotes 0/11
T9764 23290-23291 -LRB- denotes (
T9763 23280-23289 VB denotes succumbed
T9762 23275-23279 NN denotes mice
T9761 23267-23274 NN denotes control
T9760 23263-23266 DT denotes all
T9759 23257-23262 IN denotes while
T9758 23255-23256 -COMMA- denotes ,
T9757 23254-23255 -RRB- denotes )
T9756 23249-23254 CD denotes 10/11
T9755 23248-23249 -LRB- denotes (
T9754 23239-23247 VB denotes survived
T9753 23234-23238 NN denotes mice
T9752 23223-23233 NN denotes A20myel-KO
T9751 23219-23222 DT denotes all
T9750 23212-23218 RB denotes almost
T9749 23210-23211 -COMMA- denotes ,
T9748 23198-23210 RB denotes Surprisingly
T9747 23192-23196 NN denotes X-47
T9746 23188-23191 NN denotes IAV
T9745 23185-23187 IN denotes of
T9744 23180-23184 NN denotes dose
T9743 23173-23179 JJ denotes lethal
T9742 23171-23172 DT denotes a
T9741 23166-23170 IN denotes with
T9740 23156-23165 NN denotes infection
T9739 23145-23155 JJ denotes intranasal
T9738 23142-23144 IN denotes by
T9737 23134-23141 VB denotes induced
T9736 23124-23133 NN denotes mortality
T9735 23116-23123 VB denotes affects
T9734 23111-23115 NN denotes mice
T9733 23100-23110 NN denotes A20myel-KO
T9732 23097-23099 IN denotes in
T9731 23091-23096 NN denotes cells
T9730 23075-23090 JJ denotes proinflammatory
T9729 23072-23074 IN denotes of
T9728 23059-23071 NN denotes infiltration
T9727 23055-23058 CC denotes and
T9726 23044-23054 NN denotes production
T9725 23035-23043 NN denotes cytokine
T9724 23019-23034 JJ denotes proinflammatory
T9723 23009-23018 VB denotes increased
T9722 23005-23008 DT denotes the
T9721 22997-23004 IN denotes whether
T9720 22988-22996 VB denotes analyzed
T9719 22978-22987 RB denotes therefore
T9718 22975-22977 PRP denotes We
T9717 22969-22973 NN denotes lung
T9716 22965-22968 DT denotes the
T9715 22962-22964 IN denotes in
T9714 22953-22961 NN denotes response
T9713 22937-22952 JJ denotes proinflammatory
T9712 22927-22936 JJ denotes excessive
T9711 22924-22926 DT denotes an
T9710 22921-22923 TO denotes to
T9709 22917-22920 IN denotes due
T9708 22914-22916 VB denotes is
T9707 22904-22913 NN denotes mortality
T9706 22892-22903 JJ denotes IAV-induced
T9705 22887-22891 IN denotes that
T9704 22878-22886 VB denotes believed
T9703 22868-22877 RB denotes generally
T9702 22865-22867 VB denotes is
T9701 22862-22864 PRP denotes It
T9700 22856-22860 NN denotes mice
T9699 22845-22855 NN denotes A20myel-KO
T9698 22842-22844 IN denotes in
T9697 22832-22841 NN denotes clearance
T9696 22826-22831 JJ denotes viral
T9695 22819-22825 JJ denotes better
T9694 22815-22818 DT denotes the
T9693 22812-22814 TO denotes to
T9692 22801-22811 VB denotes contribute
T9691 22799-22800 -COMMA- denotes ,
T9690 22788-22799 NN denotes macrophages
T9689 22779-22787 JJ denotes alveolar
T9688 22776-22778 IN denotes of
T9687 22768-22775 NN denotes numbers
T9686 22758-22767 VB denotes increased
T9685 22754-22757 CC denotes and
T9684 22742-22753 NN denotes neutrophils
T9683 22739-22741 IN denotes of
T9682 22732-22738 NN denotes influx
T9681 22722-22731 VB denotes increased
T9680 22719-22721 DT denotes an
T9679 22716-22718 IN denotes by
T9678 22702-22715 VB denotes characterized
T9677 22700-22701 -COMMA- denotes ,
T9676 22692-22700 NN denotes response
T9675 22685-22691 JJ denotes immune
T9674 22678-22684 JJ denotes innate
T9673 22668-22677 VB denotes increased
T9672 22665-22667 DT denotes an
T9671 22662-22664 IN denotes as
T9670 22657-22661 JJ denotes such
T9580 22121-22127 NN denotes figure
T9579 22120-22121 -LRB- denotes (
T9578 22114-22119 NN denotes cells
T9577 22106-22113 JJ denotes myeloid
T9576 22103-22105 IN denotes in
T9575 22099-22102 NN denotes A20
T9574 22096-22098 IN denotes of
T9573 22088-22095 NN denotes absence
T9572 22084-22087 DT denotes the
T9571 22081-22083 IN denotes by
T9570 22073-22080 VB denotes altered
T9569 22069-22072 RB denotes not
T9568 22064-22068 VB denotes were
T9567 22058-22063 NN denotes lungs
T9566 22054-22057 DT denotes the
T9565 22051-22053 IN denotes in
T9564 22044-22050 NN denotes levels
T9563 22033-22043 NN denotes expression
T9562 22028-22032 NN denotes IFNγ
T9561 22025-22027 IN denotes as
T9560 22020-22024 RB denotes well
T9559 22017-22019 RB denotes as
T9558 22011-22016 NN denotes cells
T9557 22009-22010 NN denotes T
T9556 22004-22008 JJ denotes CD8+
T9555 21999-22003 NN denotes IFNγ
T9554 21995-21998 CC denotes and
T9553 21991-21994 NN denotes GrB
T9552 21988-21990 IN denotes of
T9551 21981-21987 NN denotes number
T9550 21977-21980 DT denotes the
T9549 21975-21976 -COMMA- denotes ,
T9548 21971-21975 RB denotes Also
T9547 21968-21969 -RRB- denotes )
T9546 21965-21968 NN denotes S2C
T9545 21958-21964 NN denotes figure
T9544 21954-21957 CC denotes and
T9543 21950-21953 NN denotes S2A
T9542 21943-21949 NN denotes figure
T9541 21942-21943 -LRB- denotes (
T9540 21937-21941 NN denotes mice
T9539 21932-21936 NN denotes type
T9538 21927-21931 JJ denotes wild
T9537 21923-21926 CC denotes and
T9536 21912-21922 NN denotes A20myel-KO
T9535 21904-21911 IN denotes between
T9534 21895-21903 VB denotes observed
T9533 21890-21894 VB denotes were
T9532 21878-21889 NN denotes differences
T9531 21875-21877 DT denotes no
T9530 21871-21874 CC denotes but
T9529 21869-21870 -COMMA- denotes ,
T9528 21860-21869 NN denotes infection
T9527 21855-21859 NN denotes post
T9526 21852-21854 CD denotes 10
T9525 21848-21851 CC denotes and
T9524 21846-21847 CD denotes 7
T9523 21842-21845 NN denotes day
T9522 21839-21841 IN denotes at
T9521 21830-21838 VB denotes detected
T9520 21827-21829 VB denotes be
T9519 21821-21826 MD denotes could
T9518 21815-21820 NN denotes cells
T9517 21813-21814 NN denotes T
T9516 21808-21812 JJ denotes CD8+
T9515 21805-21807 IN denotes in
T9514 21796-21804 NN denotes increase
T9513 21790-21795 JJ denotes clear
T9512 21788-21789 DT denotes A
T9511 21782-21786 NN denotes mice
T9510 21771-21781 NN denotes A20myel-KO
T9509 21767-21770 CC denotes and
T9508 21762-21766 NN denotes type
T9507 21757-21761 JJ denotes wild
T9506 21754-21756 IN denotes of
T9505 21743-21753 NN denotes parenchyma
T9504 21738-21742 NN denotes lung
T9503 21734-21737 CC denotes and
T9502 21730-21733 NN denotes BAL
T9501 21727-21729 IN denotes in
T9500 21718-21726 VB denotes measured
T9499 21713-21717 VB denotes were
T9498 21707-21712 NN denotes cells
T9497 21705-21706 NN denotes T
T9496 21700-21704 JJ denotes CD8+
T9495 21689-21699 VB denotes expressing
T9494 21684-21688 NN denotes IFNγ
T9493 21680-21683 CC denotes and
T9492 21678-21679 -RRB- denotes )
T9491 21675-21678 NN denotes GrB
T9490 21674-21675 -LRB- denotes (
T9489 21672-21673 NN denotes B
T9488 21663-21671 NN denotes Granzyme
T9487 21654-21662 JJ denotes specific
T9486 21648-21653 NN denotes virus
T9485 21644-21647 CC denotes and
T9484 21638-21643 NN denotes cells
T9483 21636-21637 NN denotes T
T9482 21631-21635 JJ denotes CD8+
T9481 21625-21630 JJ denotes total
T9480 21623-21624 -COMMA- denotes ,
T9479 21615-21623 NN denotes response
T9478 21611-21614 NN denotes CTL
T9477 21601-21610 JJ denotes antiviral
T9476 21597-21600 DT denotes the
T9475 21587-21596 VB denotes regulates
T9474 21581-21586 NN denotes cells
T9473 21573-21580 JJ denotes myeloid
T9472 21570-21572 IN denotes in
T9471 21559-21569 NN denotes expression
T9470 21555-21558 NN denotes A20
T9469 21547-21554 IN denotes whether
T9468 21542-21546 VB denotes test
T9467 21539-21541 TO denotes To
T9466 21536-21537 -RRB- denotes ]
T9465 21534-21536 CD denotes 63
T9464 21533-21534 -LRB- denotes [
T9463 21531-21532 -COMMA- denotes ,
T9462 21530-21531 -RRB- denotes ]
T9461 21528-21530 CD denotes 62
T9460 21527-21528 -LRB- denotes [
T9459 21525-21526 -COMMA- denotes ,
T9458 21524-21525 -RRB- denotes ]
T9457 21522-21524 CD denotes 61
T9456 21521-21522 -LRB- denotes [
T9455 21519-21520 -RRB- denotes )
T9454 21516-21519 NN denotes CTL
T9453 21515-21516 -LRB- denotes (
T9452 21509-21514 NN denotes cells
T9451 21507-21508 NN denotes T
T9450 21502-21506 JJ denotes CD8+
T9449 21492-21501 JJ denotes cytotoxic
T9448 21483-21491 JJ denotes specific
T9447 21477-21482 NN denotes virus
T9446 21474-21476 IN denotes of
T9445 21464-21473 NN denotes expansion
T9444 21457-21463 JJ denotes clonal
T9443 21453-21456 DT denotes the
T9442 21450-21452 IN denotes on
T9441 21442-21449 VB denotes depends
T9440 21436-21441 NN denotes cells
T9439 21427-21435 JJ denotes infected
T9438 21423-21426 NN denotes IAV
T9437 21420-21422 IN denotes of
T9436 21408-21419 NN denotes Elimination
T9435 21405-21406 -RRB- denotes )
T9434 21403-21405 NN denotes 3D
T9433 21396-21402 NN denotes figure
T9432 21395-21396 -LRB- denotes (
T9431 21390-21394 NN denotes mice
T9430 21381-21389 JJ denotes infected
T9429 21376-21380 JJ denotes mock
T9428 21373-21375 CC denotes or
T9427 21364-21372 JJ denotes infected
T9426 21360-21363 NN denotes IAV
T9425 21352-21359 IN denotes between
T9424 21338-21351 RB denotes significantly
T9423 21331-21337 VB denotes differ
T9422 21327-21330 RB denotes not
T9421 21323-21326 VB denotes did
T9420 21319-21322 CC denotes but
T9419 21314-21318 NN denotes mice
T9418 21303-21313 NN denotes A20myel-KO
T9417 21300-21302 IN denotes in
T9416 21291-21299 VB denotes elevated
T9415 21286-21290 RB denotes also
T9414 21282-21285 VB denotes was
T9413 21280-21281 -RRB- denotes )
T9412 21274-21280 NN denotes CD11b−
T9411 21267-21273 NN denotes F4/80+
T9410 21260-21266 JJ denotes CD11c+
T9409 21243-21259 JJ denotes autofluorescent+
T9408 21242-21243 -LRB- denotes (
T9407 21230-21241 NN denotes macrophages
T9406 21221-21229 JJ denotes alveolar
T9405 21212-21220 JJ denotes resident
T9404 21209-21211 IN denotes of
T9403 21202-21208 NN denotes number
T9402 21198-21201 DT denotes The
T9401 21192-21196 NN denotes mice
T9400 21189-21191 IN denotes of
T9399 21182-21188 NN denotes groups
T9398 21177-21181 DT denotes both
T9397 21174-21176 IN denotes in
T9396 21168-21173 NN denotes MCP-1
T9395 21165-21167 IN denotes of
T9394 21154-21164 NN denotes expression
T9393 21148-21153 JJ denotes equal
T9392 21144-21147 DT denotes the
T9391 21139-21143 IN denotes with
T9978 24478-24488 NN denotes deficiency
T9977 24474-24477 NN denotes A20
T9976 24469-24473 IN denotes that
T9975 24460-24468 VB denotes indicate
T9974 24455-24459 NN denotes data
T9973 24449-24454 DT denotes these
T9972 24436-24448 RB denotes Collectively
T9971 24433-24434 -RRB- denotes )
T9970 24428-24433 NN denotes S3B–F
T9969 24421-24427 NN denotes figure
T9968 24420-24421 -LRB- denotes (
T9967 24410-24419 NN denotes infection
T9966 24405-24409 NN denotes post
T9965 24403-24404 NN denotes h
T9964 24401-24402 CD denotes 6
T9963 24398-24400 IN denotes at
T9962 24389-24397 NN denotes immunity
T9961 24380-24388 JJ denotes adaptive
T9960 24370-24379 JJ denotes antiviral
T9959 24367-24369 CC denotes or
T9958 24357-24366 NN denotes clearance
T9957 24351-24356 JJ denotes viral
T9956 24348-24350 IN denotes in
T9955 24336-24347 NN denotes differences
T9954 24332-24335 DT denotes any
T9953 24325-24331 VB denotes detect
T9952 24321-24324 RB denotes not
T9951 24316-24320 RB denotes also
T9950 24310-24315 MD denotes could
T9949 24307-24309 PRP denotes We
T9948 24301-24305 NN denotes mice
T9947 24298-24300 IN denotes of
T9946 24291-24297 NN denotes groups
T9945 24286-24290 DT denotes both
T9944 24278-24285 IN denotes between
T9943 24268-24277 JJ denotes different
T9942 24264-24267 RB denotes not
T9941 24260-24263 VB denotes was
T9940 24248-24259 NN denotes recruitment
T9939 24239-24247 NN denotes monocyte
T9938 24234-24238 RB denotes also
T9937 24230-24233 CC denotes and
T9936 24228-24229 -COMMA- denotes ,
T9935 24227-24228 -RRB- denotes )
T9934 24225-24227 NN denotes 4C
T9933 24218-24224 NN denotes figure
T9932 24217-24218 -LRB- denotes (
T9931 24212-24216 NN denotes mice
T9930 24201-24211 NN denotes A20myel-KO
T9929 24198-24200 IN denotes in
T9928 24192-24197 JJ denotes lower
T9927 24187-24191 RB denotes even
T9926 24183-24186 CC denotes and
T9925 24173-24182 VB denotes increased
T9924 24169-24172 RB denotes not
T9923 24165-24168 VB denotes was
T9922 24154-24164 NN denotes production
T9921 24148-24153 NN denotes MCP-1
T9920 24146-24147 -COMMA- denotes ,
T9919 24141-24146 RB denotes Again
T9918 24138-24139 -RRB- denotes )
T9917 24135-24138 NN denotes S3A
T9916 24128-24134 NN denotes figure
T9915 24124-24127 CC denotes and
T9914 24121-24123 NN denotes 4C
T9913 24114-24120 NN denotes figure
T9912 24113-24114 -LRB- denotes (
T9911 24105-24112 NN denotes animals
T9910 24097-24104 NN denotes control
T9909 24094-24096 TO denotes to
T9908 24085-24093 VB denotes compared
T9907 24080-24084 NN denotes mice
T9906 24069-24079 NN denotes A20myel-KO
T9905 24066-24068 IN denotes of
T9904 24060-24065 NN denotes lungs
T9903 24056-24059 DT denotes the
T9902 24053-24055 IN denotes in
T9901 24043-24052 VB denotes increased
T9900 24038-24042 VB denotes were
T9899 24036-24037 -COMMA- denotes ,
T9898 24035-24036 -RRB- denotes ]
T9897 24033-24035 CD denotes 64
T9896 24032-24033 -LRB- denotes [
T9895 24025-24031 NN denotes humans
T9894 24022-24024 IN denotes in
T9893 24003-24021 NN denotes immunopathogenesis
T9892 23998-24002 IN denotes with
T9891 23987-23997 VB denotes associated
T9890 23981-23986 RB denotes often
T9889 23977-23980 VB denotes are
T9888 23971-23976 WDT denotes which
T9887 23969-23970 -COMMA- denotes ,
T9886 23964-23969 NN denotes IL-1β
T9390 21128-21138 JJ denotes consistent
T9389 21125-21127 VB denotes is
T9388 21119-21124 WDT denotes which
T9387 21117-21118 -COMMA- denotes ,
T9386 21116-21117 -RRB- denotes )
T9385 21114-21116 NN denotes 3D
T9384 21107-21113 NN denotes figure
T9383 21106-21107 -LRB- denotes (
T9382 21096-21105 NN denotes infection
T9381 21090-21095 IN denotes after
T9380 21083-21089 NN denotes points
T9379 21078-21082 NN denotes time
T9378 21072-21077 JJ denotes later
T9377 21069-21071 IN denotes at
T9376 21061-21068 JJ denotes evident
T9375 21057-21060 RB denotes not
T9374 21053-21056 VB denotes was
T9373 21048-21052 DT denotes this
T9372 21046-21047 -COMMA- denotes ,
T9371 21037-21046 NN denotes infection
T9370 21032-21036 NN denotes post
T9369 21030-21031 CD denotes 4
T9368 21026-21029 NN denotes day
T9367 21023-21025 IN denotes at
T9366 21011-21022 NN denotes recruitment
T9365 21009-21010 -RRB- denotes )
T9284 20516-20522 RB denotes mainly
T9283 20513-20515 VB denotes is
T9282 20507-20512 NN denotes MCP-1
T9281 20501-20506 IN denotes while
T9280 20499-20500 -COMMA- denotes ,
T9279 20488-20499 NN denotes neutrophils
T9278 20484-20487 IN denotes for
T9277 20468-20483 NN denotes chemoattractant
T9276 20466-20467 DT denotes a
T9275 20463-20465 IN denotes as
T9274 20457-20462 NN denotes MIP-2
T9273 20452-20456 IN denotes with
T9272 20443-20451 RB denotes together
T9271 20436-20442 VB denotes serves
T9270 20432-20435 CC denotes and
T9269 20427-20431 NN denotes IL-8
T9268 20424-20426 IN denotes of
T9267 20413-20423 NN denotes orthologue
T9266 20406-20412 JJ denotes murine
T9265 20402-20405 DT denotes the
T9264 20399-20401 VB denotes is
T9263 20396-20398 NN denotes KC
T9262 20393-20394 -RRB- denotes )
T9261 20391-20393 NN denotes 3C
T9260 20384-20390 NN denotes figure
T9259 20383-20384 -LRB- denotes (
T9258 20375-20382 NN denotes animals
T9257 20364-20374 NN denotes A20myel-KO
T9256 20361-20363 IN denotes of
T9255 20355-20360 NN denotes lungs
T9254 20351-20354 DT denotes the
T9253 20348-20350 IN denotes in
T9252 20337-20347 NN denotes production
T9251 20332-20336 NN denotes IFNα
T9250 20329-20331 CC denotes or
T9249 20323-20328 NN denotes MCP-1
T9248 20320-20322 IN denotes in
T9247 20311-20319 NN denotes increase
T9246 20299-20310 JJ denotes significant
T9245 20297-20298 DT denotes a
T9244 20290-20296 VB denotes detect
T9243 20286-20289 RB denotes not
T9242 20280-20285 MD denotes could
T9241 20277-20279 PRP denotes we
T9240 20265-20276 NN denotes macrophages
T9239 20257-20264 JJ denotes primary
T9238 20246-20256 VB denotes stimulated
T9237 20240-20245 FW denotes vitro
T9236 20237-20239 FW denotes in
T9235 20232-20236 IN denotes with
T9234 20219-20231 NN denotes observations
T9233 20215-20218 PRP-DOLLAR- denotes our
T9232 20208-20214 IN denotes Unlike
T9231 20205-20206 -RRB- denotes )
T9230 20203-20205 NN denotes 3C
T9229 20196-20202 NN denotes figure
T9228 20195-20196 -LRB- denotes (
T9227 20190-20194 NN denotes mice
T9226 20185-20189 NN denotes type
T9225 20180-20184 JJ denotes wild
T9224 20171-20179 JJ denotes infected
T9223 20167-20170 NN denotes IAV
T9222 20164-20166 TO denotes to
T9221 20155-20163 VB denotes compared
T9220 20150-20154 NN denotes mice
T9219 20139-20149 NN denotes A20myel-KO
T9218 20130-20138 JJ denotes infected
T9217 20126-20129 NN denotes IAV
T9216 20121-20125 IN denotes from
T9215 20117-20120 NN denotes BAL
T9214 20114-20116 IN denotes in
T9213 20109-20113 NN denotes p.i.
T9212 20107-20108 CD denotes 7
T9211 20103-20106 NN denotes day
T9210 20100-20102 IN denotes at
T9209 20093-20099 JJ denotes higher
T9208 20079-20092 RB denotes significantly
T9207 20074-20078 VB denotes were
T9206 20069-20073 NN denotes IL-6
T9205 20066-20068 IN denotes as
T9204 20061-20065 RB denotes well
T9203 20058-20060 RB denotes as
T9202 20056-20057 -COMMA- denotes ,
T9201 20046-20056 NN denotes chemokines
T9200 20040-20045 NN denotes MIP-2
T9199 20036-20039 CC denotes and
T9198 20033-20035 NN denotes KC
T9197 20030-20032 IN denotes of
T9196 20023-20029 NN denotes Levels
T9195 20012-20021 NN denotes infection
T9194 20002-20011 VB denotes following
T9193 19999-20001 CD denotes 10
T9192 19995-19998 NN denotes day
T9191 19991-19994 CC denotes and
T9190 19989-19990 CD denotes 7
T9189 19987-19988 -COMMA- denotes ,
T9188 19986-19987 CD denotes 4
T9187 19982-19985 NN denotes day
T9186 19979-19981 IN denotes at
T9185 19977-19978 -RRB- denotes )
T9184 19974-19977 NN denotes BAL
T9183 19973-19974 -LRB- denotes (
T9182 19966-19972 NN denotes lavage
T9181 19950-19965 JJ denotes bronchoalveolar
T9180 19946-19949 DT denotes the
T9179 19943-19945 IN denotes in
T9178 19933-19942 NN denotes cytokines
T9177 19929-19932 CC denotes and
T9176 19918-19928 NN denotes chemokines
T9175 19910-19917 JJ denotes several
T9174 19907-19909 IN denotes of
T9173 19900-19906 NN denotes levels
T9172 19896-19899 DT denotes the
T9171 19887-19895 VB denotes analyzed
T9170 19884-19886 PRP denotes we
T9169 19882-19883 -COMMA- denotes ,
T9168 19878-19882 NN denotes lung
T9167 19874-19877 DT denotes the
T9166 19871-19873 IN denotes in
T9165 19860-19870 NN denotes expression
T9164 19855-19859 NN denotes gene
T9163 19843-19854 JJ denotes IAV-induced
T9162 19835-19842 VB denotes affects
T9161 19829-19834 NN denotes cells
T9160 19821-19828 JJ denotes myeloid
T9159 19818-19820 IN denotes in
T9158 19807-19817 NN denotes deficiency
T9157 19803-19806 NN denotes A20
T9156 19800-19802 IN denotes if
T9155 19793-19799 VB denotes verify
T9154 19790-19792 TO denotes To
T9153 18912-18921 NN denotes infection
T9152 18905-18911 IN denotes during
T9151 18898-18904 NN denotes stages
T9150 18892-18897 JJ denotes later
T9149 18889-18891 IN denotes at
T9148 18879-18888 NN denotes clearance
T9147 18873-18878 JJ denotes viral
T9146 18870-18872 TO denotes to
T9145 18858-18869 VB denotes contributes
T9144 18854-18857 CC denotes but
T9143 18842-18853 NN denotes replication
T9142 18836-18841 JJ denotes viral
T9141 18830-18835 JJ denotes early
T9140 18823-18829 VB denotes affect
T9139 18819-18822 RB denotes not
T9138 18814-18818 VB denotes does
T9137 18808-18813 NN denotes cells
T9136 18800-18807 JJ denotes myeloid
T9135 18797-18799 IN denotes in
T9134 18793-18796 NN denotes A20
T9133 18790-18792 IN denotes of
T9132 18785-18789 NN denotes loss
T9131 18780-18784 IN denotes that
T9130 18770-18779 VB denotes indicates
T9129 18765-18769 DT denotes This
T9128 18762-18763 -RRB- denotes )
T9127 18760-18762 NN denotes 3B
T9126 18753-18759 NN denotes figure
T9125 18752-18753 -LRB- denotes (
T9124 18747-18751 NN denotes mice
T9123 18742-18746 NN denotes type
T9122 18737-18741 JJ denotes wild
T9121 18733-18736 DT denotes all
T9120 18730-18732 IN denotes of
T9119 18724-18729 NN denotes lungs
T9118 18719-18723 IN denotes from
T9117 18710-18718 VB denotes isolated
T9116 18707-18709 VB denotes be
T9115 18701-18706 RB denotes still
T9114 18695-18700 MD denotes could
T9113 18685-18694 NN denotes particles
T9112 18679-18684 JJ denotes viral
T9111 18668-18678 JJ denotes infectious
T9110 18659-18667 JJ denotes abundant
T9109 18653-18658 IN denotes while
T9108 18648-18652 NN denotes mice
T9107 18637-18647 NN denotes A20myel-KO
T9106 18634-18636 IN denotes of
T9105 18628-18633 NN denotes lungs
T9104 18624-18627 DT denotes the
T9103 18621-18623 IN denotes in
T9102 18612-18620 VB denotes detected
T9101 18609-18611 VB denotes be
T9100 18603-18608 MD denotes could
T9099 18597-18602 NN denotes virus
T9098 18594-18596 DT denotes no
T9097 18587-18593 RB denotes almost
T9096 18585-18586 -COMMA- denotes ,
T9095 18581-18585 NN denotes days
T9669 22655-22656 -COMMA- denotes ,
T9668 22647-22655 NN denotes immunity
T9667 22638-22646 JJ denotes adaptive
T9666 22633-22637 IN denotes than
T9665 22627-22632 JJ denotes other
T9664 22616-22626 NN denotes mechanisms
T9663 22611-22615 IN denotes that
T9662 22603-22610 VB denotes suggest
T9661 22598-22602 NN denotes data
T9660 22592-22597 DT denotes these
T9659 22590-22591 -COMMA- denotes ,
T9658 22582-22590 RB denotes Together
T9657 22575-22580 NN denotes cells
T9656 22567-22574 JJ denotes myeloid
T9655 22564-22566 IN denotes in
T9654 22553-22563 NN denotes expression
T9653 22549-22552 NN denotes A20
T9652 22546-22548 IN denotes by
T9651 22537-22545 VB denotes affected
T9650 22533-22536 RB denotes not
T9649 22530-22532 VB denotes is
T9648 22521-22529 NN denotes immunity
T9647 22513-22520 JJ denotes humoral
T9646 22508-22512 IN denotes that
T9645 22497-22507 VB denotes indicating
T9644 22495-22496 -COMMA- denotes ,
T9643 22494-22495 -RRB- denotes )
T9642 22491-22494 NN denotes S2D
T9641 22484-22490 NN denotes figure
T9640 22483-22484 -LRB- denotes (
T9639 22475-22482 NN denotes animals
T9638 22464-22474 NN denotes A20myel-KO
T9637 22460-22463 CC denotes and
T9636 22455-22459 NN denotes type
T9635 22450-22454 JJ denotes wild
T9634 22442-22449 IN denotes between
T9633 22433-22441 VB denotes detected
T9632 22430-22432 VB denotes be
T9631 22424-22429 MD denotes could
T9630 22412-22423 NN denotes differences
T9629 22409-22411 DT denotes no
T9628 22407-22408 -COMMA- denotes ,
T9627 22400-22407 RB denotes However
T9626 22387-22398 NN denotes littermates
T9625 22382-22386 NN denotes type
T9624 22377-22381 JJ denotes wild
T9623 22373-22376 CC denotes and
T9622 22362-22372 NN denotes A20myel-KO
T9621 22359-22361 IN denotes of
T9620 22353-22358 NN denotes serum
T9619 22349-22352 DT denotes the
T9618 22346-22348 IN denotes in
T9617 22339-22345 NN denotes titers
T9616 22330-22338 NN denotes antibody
T9615 22328-22329 -RRB- denotes )
T9614 22326-22328 NN denotes HA
T9613 22325-22326 -LRB- denotes (
T9612 22311-22324 NN denotes hemagglutinin
T9611 22300-22310 VB denotes determined
T9610 22297-22299 PRP denotes we
T9609 22295-22296 -COMMA- denotes ,
T9608 22287-22295 NN denotes immunity
T9607 22278-22286 VB denotes mediated
T9606 22273-22277 NN denotes cell
T9605 22271-22272 NN denotes B
T9604 22263-22270 VB denotes affects
T9603 22257-22262 NN denotes cells
T9602 22249-22256 JJ denotes myeloid
T9601 22246-22248 IN denotes in
T9600 22242-22245 NN denotes A20
T9599 22239-22241 IN denotes of
T9598 22234-22238 NN denotes loss
T9597 22226-22233 IN denotes whether
T9596 22221-22225 VB denotes test
T9595 22218-22220 TO denotes To
T9594 22208-22216 NN denotes response
T9593 22201-22207 JJ denotes immune
T9592 22193-22200 JJ denotes humoral
T9591 22189-22192 DT denotes the
T9590 22186-22188 IN denotes by
T9589 22177-22185 VB denotes provided
T9588 22172-22176 RB denotes also
T9587 22169-22171 VB denotes is
T9586 22159-22168 NN denotes infection
T9585 22155-22158 NN denotes IAV
T9584 22147-22154 IN denotes against
T9583 22136-22146 NN denotes Protection
T9582 22133-22134 -RRB- denotes )
T9581 22128-22133 NN denotes S2A–C
T9094 18578-18580 CD denotes 10
T9093 18572-18577 IN denotes after
T9092 18570-18571 -COMMA- denotes ,
T9091 18563-18570 RB denotes However
T9090 18552-18561 NN denotes infection
T9089 18547-18551 NN denotes post
T9088 18545-18546 CD denotes 7
T9087 18541-18544 CC denotes and
T9086 18539-18540 CD denotes 4
T9085 18535-18538 NN denotes day
T9084 18532-18534 IN denotes at
T9083 18527-18531 NN denotes mice
T9082 18522-18526 NN denotes type
T9081 18517-18521 JJ denotes wild
T9080 18510-18516 IN denotes versus
T9079 18505-18509 NN denotes mice
T9078 18494-18504 NN denotes A20myel-KO
T9077 18491-18493 IN denotes in
T9076 18482-18490 VB denotes observed
T9075 18477-18481 VB denotes were
T9074 18470-18476 NN denotes titers
T9073 18464-18469 JJ denotes viral
T9072 18461-18463 IN denotes in
T9071 18449-18460 NN denotes differences
T9070 18446-18448 DT denotes No
T9069 18435-18444 NN denotes infection
T9047 18335-18345 NN denotes A20myel-KO
T9046 18332-18334 IN denotes in
T9045 18326-18331 JJ denotes lower
T9044 18317-18325 RB denotes slightly
T9043 18313-18316 VB denotes was
T9042 18309-18312 CC denotes and
T9041 18307-18308 -COMMA- denotes ,
T9040 18303-18307 NN denotes mice
T9039 18292-18302 NN denotes A20myel-KO
T9038 18288-18291 CC denotes and
T9037 18283-18287 NN denotes type
T9036 18278-18282 JJ denotes wild
T9035 18273-18277 CC denotes both
T9034 18270-18272 IN denotes in
T9033 18260-18269 NN denotes infection
T9032 18255-18259 VB denotes post
T9031 18250-18254 NN denotes days
T9030 18247-18249 CD denotes 10
T9029 18243-18246 CC denotes and
T9028 18241-18242 CD denotes 7
T9027 18238-18240 IN denotes at
T9026 18224-18237 RB denotes significantly
T9025 18214-18223 VB denotes increased
T9024 18210-18213 VB denotes was
T9023 18208-18209 -COMMA- denotes ,
T9022 18201-18208 NN denotes leakage
T9021 18192-18200 JJ denotes vascular
T9020 18188-18191 CC denotes and
T9019 18181-18187 NN denotes damage
T9018 18176-18180 NN denotes lung
T9017 18167-18175 VB denotes reflects
T9016 18161-18166 WDT denotes which
T9015 18159-18160 -COMMA- denotes ,
T9014 18154-18159 NN denotes fluid
T9013 18150-18153 NN denotes BAL
T9012 18147-18149 IN denotes in
T9011 18133-18146 NN denotes concentration
T9010 18125-18132 NN denotes protein
T9009 18119-18124 JJ denotes total
T9008 18117-18118 -COMMA- denotes ,
T9007 18113-18117 RB denotes Also
T9006 18110-18111 -RRB- denotes )
T9005 18108-18110 NN denotes 3A
T9004 18101-18107 NN denotes figure
T9003 18100-18101 -LRB- denotes (
T9002 18090-18099 NN denotes challenge
T9001 18084-18089 JJ denotes viral
T9000 18080-18083 DT denotes the
T8999 18075-18079 IN denotes from
T8998 18068-18074 RB denotes faster
T8997 18058-18067 VB denotes recovered
T8996 18054-18057 CC denotes and
T8995 18042-18053 NN denotes littermates
T8994 18034-18041 NN denotes control
T8993 18029-18033 NN denotes type
T8992 18024-18028 JJ denotes wild
T8991 18021-18023 TO denotes to
T8990 18012-18020 VB denotes compared
T8989 18007-18011 NN denotes loss
T8988 18000-18006 NN denotes weight
T8987 17992-17999 VB denotes reduced
T8986 17985-17991 VB denotes showed
T8985 17980-17984 NN denotes mice
T8984 17969-17979 NN denotes A20myel-KO
T8983 17963-17967 NN denotes loss
T8982 17956-17962 NN denotes weight
T8981 17953-17955 IN denotes of
T8980 17947-17952 NN denotes terms
T8979 17944-17946 IN denotes in
T8978 17934-17943 NN denotes morbidity
T8977 17924-17933 VB denotes monitored
T8976 17920-17923 CC denotes and
T8975 17913-17919 NN denotes strain
T8974 17911-17912 -RRB- denotes )
T8973 17907-17911 NN denotes H3N2
T8972 17906-17907 -LRB- denotes (
T8971 17901-17905 NN denotes X-47
T8970 17897-17900 NN denotes IAV
T8969 17889-17896 VB denotes adapted
T8968 17883-17888 NN denotes mouse
T8967 17879-17882 DT denotes the
T8966 17876-17878 IN denotes of
T8965 17871-17875 NN denotes dose
T8964 17861-17870 JJ denotes sublethal
T8963 17859-17860 DT denotes a
T8962 17854-17858 IN denotes with
T8961 17842-17853 NN denotes littermates
T8960 17834-17841 NN denotes control
T8959 17830-17833 CC denotes and
T8958 17825-17829 NN denotes mice
T8957 17814-17824 NN denotes A20myel-KO
T8956 17809-17813 CC denotes both
T8955 17798-17808 VB denotes inoculated
T8954 17785-17797 RB denotes intranasally
T8953 17782-17784 PRP denotes we
T8952 17780-17781 -COMMA- denotes ,
T8951 17776-17780 FW denotes vivo
T8950 17773-17775 FW denotes in
T8949 17763-17772 NN denotes infection
T8948 17759-17762 NN denotes IAV
T8947 17756-17758 DT denotes an
T8946 17749-17755 IN denotes during
T8945 17743-17748 NN denotes cells
T8944 17735-17742 JJ denotes myeloid
T8943 17732-17734 IN denotes in
T8942 17721-17731 NN denotes expression
T8941 17717-17720 NN denotes A20
T8940 17714-17716 IN denotes of
T8939 17709-17713 NN denotes role
T8938 17705-17708 DT denotes the
T8937 17695-17704 VB denotes determine
T8936 17692-17694 TO denotes To
T8935 17682-17691 NN denotes infection
T8934 17677-17681 NN denotes lung
T8933 17673-17676 NN denotes IAV
T8932 17665-17672 IN denotes against
T8931 17656-17664 VB denotes protects
T8930 17650-17655 NN denotes cells
T8929 17642-17649 JJ denotes myeloid
T8928 17639-17641 IN denotes in
T8927 17628-17638 NN denotes deficiency
T9364 21004-21009 NN denotes Ly6C+
T9363 20997-21003 JJ denotes CD11b+
T9362 20996-20997 -LRB- denotes (
T9361 20987-20995 NN denotes monocyte
T9360 20984-20986 IN denotes in
T9359 20975-20983 NN denotes increase
T9358 20963-20974 JJ denotes significant
T9357 20961-20962 DT denotes a
T9356 20954-20960 VB denotes detect
T9355 20948-20953 MD denotes could
T9354 20945-20947 PRP denotes we
T9353 20936-20944 IN denotes Although
T9352 20933-20934 -RRB- denotes )
T9351 20931-20933 NN denotes 3D
T9350 20924-20930 NN denotes figure
T9349 20923-20924 -LRB- denotes (
T9348 20915-20922 NN denotes animals
T9347 20907-20914 NN denotes control
T9346 20904-20906 TO denotes to
T9345 20895-20903 VB denotes compared
T9344 20890-20894 NN denotes mice
T9343 20879-20889 NN denotes A20myel-KO
T9342 20876-20878 IN denotes in
T9341 20866-20875 NN denotes infection
T9340 20855-20865 IN denotes throughout
T9339 20848-20854 JJ denotes higher
T9338 20840-20847 RB denotes clearly
T9337 20836-20839 VB denotes was
T9336 20826-20835 NN denotes infection
T9335 20822-20825 NN denotes IAV
T9334 20817-20821 IN denotes upon
T9333 20810-20816 NN denotes spaces
T9332 20794-20809 JJ denotes bronchoalveolar
T9331 20790-20793 DT denotes the
T9330 20787-20789 IN denotes in
T9329 20777-20786 VB denotes recruited
T9328 20772-20776 VB denotes were
T9327 20767-20771 WDT denotes that
T9326 20765-20766 -RRB- denotes )
T9325 20759-20765 NN denotes F4/80−
T9324 20753-20758 JJ denotes Ly6G+
T9323 20747-20752 JJ denotes Ly6C+
T9322 20740-20746 JJ denotes CD11b+
T9321 20739-20740 -LRB- denotes (
T9320 20727-20738 NN denotes neutrophils
T9319 20724-20726 IN denotes of
T9318 20717-20723 NN denotes number
T9317 20713-20716 DT denotes the
T9316 20711-20712 -COMMA- denotes ,
T9315 20707-20711 NN denotes mice
T9314 20696-20706 NN denotes A20myel-KO
T9313 20693-20695 IN denotes in
T9312 20686-20692 NN denotes levels
T9311 20680-20685 NN denotes MIP-2
T9310 20676-20679 CC denotes and
T9309 20673-20675 NN denotes KC
T9308 20666-20672 JJ denotes higher
T9307 20662-20665 DT denotes the
T9306 20657-20661 IN denotes with
T9305 20646-20656 JJ denotes Consistent
T9304 20643-20644 -RRB- denotes ]
T9303 20641-20643 CD denotes 60
T9302 20640-20641 -LRB- denotes [
T9301 20634-20639 NN denotes lumen
T9300 20625-20633 JJ denotes alveolar
T9299 20621-20624 DT denotes the
T9298 20612-20620 VB denotes entering
T9297 20607-20611 IN denotes upon
T9296 20595-20606 NN denotes macrophages
T9295 20590-20594 IN denotes into
T9294 20582-20589 VB denotes develop
T9293 20571-20581 RB denotes eventually
T9292 20565-20570 WDT denotes which
T9291 20563-20564 -COMMA- denotes ,
T9290 20554-20563 NN denotes monocytes
T9289 20550-20553 IN denotes for
T9288 20534-20549 NN denotes chemoattractant
T9287 20532-20533 DT denotes a
T9286 20529-20531 IN denotes as
T9285 20523-20528 VB denotes known
T9068 18430-18434 JJ denotes post
T9067 18425-18429 NN denotes days
T9066 18422-18424 CD denotes 10
T9065 18418-18421 CC denotes and
T9064 18416-18417 CD denotes 7
T9063 18414-18415 -COMMA- denotes ,
T9062 18413-18414 CD denotes 4
T9061 18410-18412 IN denotes at
T9060 18403-18409 NN denotes titers
T9059 18397-18402 JJ denotes viral
T9058 18387-18396 JJ denotes pulmonary
T9057 18378-18386 VB denotes measured
T9056 18375-18377 PRP denotes we
T9055 18373-18374 -COMMA- denotes ,
T9054 18369-18373 RB denotes Next
T9053 18366-18367 -RRB- denotes )
T9052 18361-18366 VB denotes shown
T9051 18357-18360 RB denotes not
T9050 18352-18356 NN denotes data
T9049 18351-18352 -LRB- denotes (
T9048 18346-18350 NN denotes mice
T8064 17611-17621 NN denotes activation
T8063 17606-17610 NN denotes IRF3
T8062 17602-17605 CC denotes and
T8061 17596-17601 NN denotes NF-κB
T8060 17582-17595 JJ denotes RIG-I-induced
T8059 17579-17581 IN denotes on
T8058 17574-17578 VB denotes seen
T8057 17570-17573 NN denotes A20
T8056 17567-17569 IN denotes of
T8055 17560-17566 NN denotes effect
T8054 17549-17559 JJ denotes inhibitory
T8053 17545-17548 DT denotes the
T8052 17540-17544 IN denotes with
T8051 17529-17539 JJ denotes consistent
T8050 17527-17528 -COMMA- denotes ,
T8049 17516-17527 NN denotes macrophages
T8048 17507-17515 JJ denotes alveolar
T8047 17504-17506 IN denotes in
T8046 17493-17503 NN denotes expression
T8045 17488-17492 NN denotes gene
T8044 17478-17487 JJ denotes antiviral
T8043 17474-17477 CC denotes and
T8042 17458-17473 JJ denotes proinflammatory
T8041 17446-17457 JJ denotes IAV-induced
T8040 17436-17445 VB denotes regulates
T8039 17425-17435 RB denotes negatively
T8038 17421-17424 NN denotes A20
T8037 17416-17420 IN denotes that
T8036 17404-17415 VB denotes demonstrate
T8035 17396-17403 NN denotes results
T8034 17390-17395 DT denotes these
T8033 17381-17389 RB denotes together
T8032 17375-17380 VB denotes Taken
T8031 17372-17373 -RRB- denotes )
T8030 17370-17372 NN denotes S1
T8029 17363-17369 NN denotes figure
T8028 17359-17362 CC denotes and
T8027 17356-17358 NN denotes 2C
T8026 17349-17355 NN denotes figure
T8010 17252-17255 VB denotes was
T8009 17250-17251 -RRB- denotes )
T8008 17245-17250 NN denotes cxcl1
T8007 17244-17245 -LRB- denotes (
T8006 17241-17243 NN denotes KC
T8005 17237-17240 CC denotes and
T8004 17235-17236 -RRB- denotes )
T8003 17231-17235 NN denotes ccl2
T8002 17230-17231 -LRB- denotes (
T8001 17224-17229 NN denotes MCP-1
T8000 17213-17223 NN denotes chemokines
T7999 17209-17212 DT denotes the
T7998 17205-17208 CC denotes and
T7997 17199-17204 NN denotes IFNα4
T7996 17195-17198 CC denotes and
T7995 17190-17194 NN denotes IFNβ
T7994 17186-17189 NN denotes IFN
T7993 17179-17185 NN denotes type-I
T7992 17175-17178 DT denotes the
T7991 17173-17174 -COMMA- denotes ,
T7990 17170-17173 NN denotes TNF
T7989 17166-17169 CC denotes and
T7988 17161-17165 NN denotes IL-6
T7987 17151-17160 NN denotes cytokines
T7986 17135-17150 JJ denotes proinflammatory
T7985 17131-17134 DT denotes the
T7984 17128-17130 IN denotes of
T7983 17118-17127 NN denotes secretion
T7982 17114-17117 CC denotes and
T7981 17103-17113 NN denotes Expression
T7980 17097-17101 NN denotes X-47
T7979 17093-17096 NN denotes IAV
T7978 17088-17092 IN denotes with
T7977 17082-17087 FW denotes vitro
T7976 17079-17081 FW denotes in
T7975 17074-17078 PRP denotes them
T7974 17065-17073 VB denotes infected
T7973 17061-17064 CC denotes and
T7972 17049-17060 NN denotes littermates
T7971 17041-17048 NN denotes control
T7970 17037-17040 CC denotes and
T7969 17026-17036 NN denotes A20myel-KO
T7968 17023-17025 IN denotes of
T7967 17017-17022 NN denotes lungs
T7966 17012-17016 IN denotes from
T7965 17006-17011 NN denotes cells
T7964 17000-17005 DT denotes these
T7963 16991-16999 VB denotes isolated
T7962 16988-16990 PRP denotes we
T7961 16986-16987 -COMMA- denotes ,
T7960 16975-16986 NN denotes macrophages
T7959 16966-16974 JJ denotes alveolar
T7958 16963-16965 IN denotes in
T7957 16952-16962 NN denotes expression
T7956 16947-16951 NN denotes gene
T7955 16935-16946 JJ denotes IAV-induced
T7954 16926-16934 VB denotes controls
T7953 16917-16925 RB denotes directly
T7952 16913-16916 NN denotes A20
T7951 16905-16912 IN denotes whether
T7950 16900-16904 VB denotes test
T7949 16897-16899 TO denotes To
T7948 16886-16895 NN denotes infection
T7947 16883-16885 IN denotes of
T7946 16877-16882 NN denotes phase
T7945 16869-16876 JJ denotes primary
T7944 16865-16868 DT denotes the
T7943 16858-16864 IN denotes during
T7942 16853-16857 NN denotes lung
T7941 16849-16852 DT denotes the
T7940 16846-16848 TO denotes to
T7939 16840-16845 NN denotes cells
T7938 16833-16839 JJ denotes immune
T7937 16826-16832 JJ denotes innate
T7936 16815-16825 VB denotes attracting
T7935 16813-16814 -COMMA- denotes ,
T7934 16803-16813 NN denotes chemokines
T7933 16799-16802 CC denotes and
T7932 16789-16798 NN denotes cytokines
T7931 16786-16788 IN denotes of
T7930 16779-16785 NN denotes source
T7929 16769-16778 JJ denotes important
T7928 16766-16768 DT denotes an
T7927 16762-16765 VB denotes are
T7926 16750-16761 NN denotes macrophages
T7925 16741-16749 JJ denotes alveolar
T7924 16739-16740 -COMMA- denotes ,
T7923 16736-16739 NN denotes IAV
T7922 16731-16735 IN denotes with
T7921 16721-16730 NN denotes infection
T7920 16716-16720 NN denotes host
T7919 16711-16715 IN denotes Upon
T7918 15829-15830 -RRB- denotes )
T7917 15827-15829 NN denotes 2B
T7916 15820-15826 NN denotes figure
T7915 15819-15820 -LRB- denotes (
T7914 15814-15818 NN denotes IFNβ
T7913 15810-15813 CC denotes and
T7912 15806-15809 NN denotes TNF
T7911 15803-15805 IN denotes of
T7910 15796-15802 NN denotes levels
T7909 15789-15795 JJ denotes higher
T7908 15779-15788 VB denotes contained
T7907 15773-15778 NN denotes cells
T7906 15767-15772 DT denotes these
T7905 15762-15766 IN denotes from
T7904 15752-15761 VB denotes collected
T7903 15740-15751 NN denotes supernatant
T7902 15732-15739 NN denotes culture
T7901 15727-15731 NN denotes cell
T7900 15725-15726 -COMMA- denotes ,
T7899 15721-15725 NN denotes data
T7898 15715-15720 DT denotes these
T7897 15710-15714 IN denotes with
T7896 15699-15709 NN denotes accordance
T7895 15696-15698 IN denotes In
T7894 15693-15694 -RRB- denotes )
T7893 15691-15693 NN denotes 2A
T7892 15684-15690 NN denotes figure
T7891 15683-15684 -LRB- denotes (
T7890 15677-15682 NN denotes cells
T7889 15669-15676 NN denotes control
T7888 15666-15668 TO denotes to
T7887 15657-15665 VB denotes compared
T7886 15647-15656 NN denotes infection
T7885 15643-15646 NN denotes IAV
T7884 15637-15642 IN denotes after
T7883 15632-15636 NN denotes mRNA
T7882 15627-15631 NN denotes IFNβ
T7881 15623-15626 CC denotes and
T7880 15618-15622 NN denotes IL-6
T7879 15615-15617 IN denotes of
T7878 15604-15614 NN denotes expression
T7877 15595-15603 VB denotes enhanced
T7876 15590-15594 VB denotes show
T7875 15585-15589 NN denotes BMDM
T7874 15574-15584 NN denotes A20myel-KO
T7873 15572-15573 -COMMA- denotes ,
T7872 15561-15572 RB denotes Furthermore
T7871 15558-15559 -RRB- denotes )
T7870 15556-15558 NN denotes 2A
T7869 15549-15555 NN denotes figure
T7868 15548-15549 -LRB- denotes (
T7867 15538-15547 NN denotes infection
T7866 15532-15537 JJ denotes viral
T7865 15527-15531 IN denotes upon
T7864 15525-15526 -COMMA- denotes ,
T7863 15521-15525 NN denotes BMDM
T7862 15511-15520 JJ denotes deficient
T7861 15507-15510 NN denotes A20
T7860 15504-15506 IN denotes in
T7859 15500-15503 RB denotes not
T7858 15496-15499 CC denotes but
T7857 15494-15495 -COMMA- denotes ,
T7856 15490-15494 NN denotes BMDM
T7855 15485-15489 NN denotes type
T7854 15480-15484 JJ denotes wild
T7853 15477-15479 IN denotes in
T7852 15469-15476 VB denotes induced
T7851 15461-15468 RB denotes rapidly
T7850 15456-15460 VB denotes were
T7849 15449-15455 NN denotes levels
T7848 15444-15448 NN denotes mRNA
T7847 15440-15443 NN denotes A20
T7846 15437-15438 -RRB- denotes )
T7845 15433-15437 NN denotes H3N2
T7844 15432-15433 -LRB- denotes (
T7843 15427-15431 NN denotes X-47
T7842 15423-15426 NN denotes IAV
T7841 15418-15422 IN denotes with
T7840 15413-15417 NN denotes BMDM
T7839 15405-15412 NN denotes control
T7838 15401-15404 CC denotes and
T7837 15391-15400 JJ denotes deficient
T7836 15387-15390 NN denotes A20
T7835 15378-15386 VB denotes infected
T7834 15375-15377 PRP denotes we
T7833 15373-15374 -COMMA- denotes ,
T7832 15364-15373 NN denotes responses
T7831 15357-15363 JJ denotes immune
T7830 15350-15356 JJ denotes innate
T7829 15340-15349 JJ denotes antiviral
T7828 15336-15339 CC denotes and
T7827 15320-15335 JJ denotes proinflammatory
T7826 15308-15319 JJ denotes IAV-induced
T7825 15304-15307 DT denotes the
T7824 15301-15303 IN denotes in
T7823 15297-15300 NN denotes A20
T7822 15294-15296 IN denotes of
T7821 15289-15293 NN denotes role
T7820 15285-15288 DT denotes the
T7819 15273-15284 VB denotes investigate
T7818 15270-15272 TO denotes To
T7817 15265-15269 NN denotes BMDM
T7816 15262-15264 IN denotes in
T7815 15251-15261 NN denotes expression
T7814 15246-15250 NN denotes gene
T7813 15234-15245 JJ denotes IAV-induced
T7812 15224-15233 VB denotes regulates
T7811 15213-15223 RB denotes negatively
T7810 15209-15212 NN denotes A20
T8025 17348-17349 -LRB- denotes (
T8024 17342-17347 NN denotes cells
T8023 17337-17341 NN denotes type
T8022 17332-17336 JJ denotes wild
T8021 17323-17331 JJ denotes infected
T8020 17320-17322 TO denotes to
T8019 17311-17319 VB denotes compared
T8018 17307-17310 NN denotes A20
T8017 17299-17306 VB denotes lacking
T8016 17293-17298 NN denotes cells
T8015 17284-17292 JJ denotes infected
T8014 17280-17283 NN denotes IAV
T8013 17277-17279 IN denotes in
T8012 17270-17276 JJ denotes higher
T8011 17256-17269 RB denotes significantly
T5660 14118-14122 NN denotes type
T5659 14113-14117 JJ denotes wild
T5658 14110-14112 TO denotes to
T5657 14101-14109 VB denotes compared
T5656 14094-14100 NN denotes points
T5655 14089-14093 NN denotes time
T5654 14081-14088 JJ denotes earlier
T5653 14078-14080 IN denotes at
T5652 14070-14077 NN denotes maximum
T5651 14068-14069 DT denotes a
T5650 14059-14067 VB denotes reaching
T5649 14057-14058 -COMMA- denotes ,
T5648 14053-14057 NN denotes BMDM
T5647 14042-14052 NN denotes A20myel-KO
T5646 14030-14041 VB denotes transfected
T5645 14028-14029 -RRB- denotes )
T5644 14027-14028 NN denotes C
T5643 14026-14027 SYM denotes :
T5642 14025-14026 NN denotes I
T5641 14024-14025 -LRB- denotes (
T5640 14020-14024 NN denotes poly
T5639 14017-14019 IN denotes in
T5638 14008-14016 VB denotes enhanced
T5637 14004-14007 VB denotes was
T5636 13996-14003 NN denotes subunit
T5635 13990-13995 NN denotes NF-κB
T5634 13986-13989 NN denotes p65
T5633 13982-13985 DT denotes the
T5632 13979-13981 IN denotes of
T5631 13965-13978 NN denotes translocation
T5630 13957-13964 JJ denotes nuclear
T5629 13955-13956 -COMMA- denotes ,
T5628 13944-13955 RB denotes Furthermore
T5627 13941-13942 -RRB- denotes )
T5626 13939-13941 NN denotes 1B
T5625 13932-13938 NN denotes figure
T5624 13931-13932 -LRB- denotes (
T5623 13926-13930 NN denotes IκBα
T5622 13923-13925 IN denotes of
T5621 13911-13922 NN denotes degradation
T5620 13901-13910 JJ denotes sustained
T5619 13897-13900 CC denotes and
T5618 13881-13896 NN denotes phosphorylation
T5617 13871-13880 VB denotes increased
T5616 13868-13870 IN denotes by
T5615 13858-13867 VB denotes indicated
T5614 13855-13857 IN denotes as
T5613 13844-13854 NN denotes activation
T5612 13838-13843 NN denotes NF-κB
T5611 13829-13837 VB denotes enhanced
T5610 13822-13828 VB denotes showed
T5609 13816-13821 NN denotes cells
T5608 13806-13815 JJ denotes deficient
T5607 13802-13805 NN denotes A20
T5606 13800-13801 -COMMA- denotes ,
T5605 13796-13800 NN denotes BMBM
T5604 13791-13795 NN denotes type
T5603 13786-13790 JJ denotes wild
T5602 13783-13785 TO denotes to
T5601 13774-13782 VB denotes Compared
T5600 13760-13772 NN denotes transfection
T5599 13758-13759 -RRB- denotes )
T5598 13757-13758 NN denotes C
T5597 13756-13757 SYM denotes :
T5596 13755-13756 NN denotes I
T5595 13754-13755 -LRB- denotes (
T5594 13750-13754 NN denotes poly
T5593 13745-13749 IN denotes upon
T5592 13732-13744 NN denotes modification
T5591 13724-13731 JJ denotes unknown
T5590 13720-13723 RB denotes yet
T5589 13718-13719 DT denotes a
T5588 13708-13717 VB denotes undergoes
T5587 13704-13707 NN denotes A20
T5586 13699-13703 IN denotes that
T5585 13688-13698 VB denotes indicating
T5584 13686-13687 -COMMA- denotes ,
T5583 13678-13686 VB denotes observed
T5582 13673-13677 VB denotes were
T5581 13669-13672 NN denotes A20
T5580 13666-13668 IN denotes of
T5579 13660-13665 NN denotes forms
T5578 13650-13659 JJ denotes migrating
T5577 13643-13649 JJ denotes slower
T5576 13634-13642 RB denotes slightly
T5575 13632-13633 -COMMA- denotes ,
T5574 13626-13632 NN denotes points
T5573 13621-13625 NN denotes time
T5572 13615-13620 JJ denotes early
T5571 13612-13614 IN denotes At
T5570 13609-13610 -RRB- denotes )
T5569 13604-13609 NN denotes panel
T5568 13598-13603 JJ denotes upper
T5567 13596-13597 -COMMA- denotes ,
T5566 13594-13596 NN denotes 1B
T5565 13587-13593 NN denotes figure
T5564 13586-13587 -LRB- denotes (
T5563 13581-13585 NN denotes BMDM
T5562 13570-13580 NN denotes A20myel-KO
T5561 13567-13569 IN denotes in
T5560 13563-13566 RB denotes not
T5559 13559-13562 CC denotes but
T5558 13557-13558 -COMMA- denotes ,
T5557 13553-13557 NN denotes type
T5556 13548-13552 JJ denotes wild
T5555 13545-13547 IN denotes in
T5554 13541-13544 NN denotes A20
T5553 13538-13540 IN denotes of
T5552 13527-13537 NN denotes expression
T5551 13521-13526 JJ denotes rapid
T5550 13517-13520 DT denotes the
T5549 13509-13516 VB denotes induced
T5548 13496-13508 NN denotes transfection
T5547 13494-13495 -RRB- denotes )
T5546 13493-13494 NN denotes C
T5545 13492-13493 SYM denotes :
T5544 13491-13492 NN denotes I
T5543 13490-13491 -LRB- denotes (
T5542 13486-13490 NN denotes poly
T5541 13484-13485 -COMMA- denotes ,
T5540 13476-13484 VB denotes expected
T5539 13473-13475 IN denotes As
T5538 13470-13471 -RRB- denotes )
T5537 13465-13470 VB denotes shown
T5536 13461-13464 RB denotes not
T5535 13456-13460 NN denotes data
T5534 13455-13456 -LRB- denotes (
T5533 13444-13454 NN denotes production
T5532 13435-13443 NN denotes cytokine
T5531 13432-13434 CC denotes or
T5530 13421-13431 NN denotes activation
T5529 13416-13420 NN denotes IRF3
T5528 13412-13415 CC denotes and
T5527 13406-13411 NN denotes NF-κB
T5526 13396-13405 JJ denotes dependent
T5525 13391-13395 NN denotes TLR3
T5524 13379-13390 JJ denotes significant
T5523 13372-13378 VB denotes induce
T5522 13369-13371 TO denotes to
T5521 13362-13368 JJ denotes unable
T5520 13358-13361 VB denotes was
T5519 13356-13357 -RRB- denotes )
T5518 13355-13356 NN denotes C
T5517 13354-13355 SYM denotes :
T5516 13353-13354 NN denotes I
T5515 13352-13353 -LRB- denotes (
T5514 13348-13352 NN denotes poly
T5513 13345-13347 IN denotes of
T5512 13331-13344 NN denotes concentration
T5511 13326-13330 DT denotes this
T5510 13324-13325 -COMMA- denotes ,
T5509 13320-13324 NN denotes note
T5508 13317-13319 IN denotes Of
T5507 13314-13315 -RRB- denotes ]
T5506 13312-13314 CD denotes 57
T5505 13311-13312 -LRB- denotes [
T5504 13306-13310 NN denotes MDA5
T5503 13301-13305 IN denotes than
T5502 13294-13300 RB denotes rather
T5501 13288-13293 NN denotes RIG-I
T5500 13279-13287 VB denotes activate
T5499 13275-13278 CC denotes and
T5498 13270-13274 VB denotes bind
T5497 13255-13269 RB denotes preferentially
T5496 13252-13254 TO denotes to
T5495 13246-13251 VB denotes known
T5494 13243-13245 VB denotes is
T5493 13237-13242 WDT denotes which
T5492 13235-13236 -COMMA- denotes ,
T5491 13234-13235 -RRB- denotes )
T5490 13233-13234 NN denotes C
T5489 13232-13233 SYM denotes :
T5488 13231-13232 NN denotes I
T5487 13230-13231 -LRB- denotes (
T5486 13226-13230 NN denotes poly
T5485 13224-13225 -RRB- denotes )
T5484 13221-13224 NN denotes LMW
T5483 13220-13221 -LRB- denotes (
T5482 13213-13219 NN denotes weight
T5481 13203-13212 JJ denotes molecular
T5480 13199-13202 JJ denotes low
T5479 13196-13198 IN denotes of
T5478 13188-13195 NN denotes amounts
T5477 13180-13187 JJ denotes minimal
T5476 13175-13179 IN denotes with
T5475 13169-13174 NN denotes cells
T5474 13161-13168 NN denotes control
T5473 13156-13160 NN denotes type
T5472 13151-13155 JJ denotes wild
T5471 13147-13150 CC denotes and
T5470 13142-13146 NN denotes BMDM
T5469 13131-13141 NN denotes A20myel-KO
T5468 13119-13130 VB denotes transfected
T5467 13116-13118 PRP denotes we
T5466 13114-13115 -COMMA- denotes ,
T5465 13106-13114 NN denotes receptor
T5464 13100-13105 NN denotes RIG-I
T5463 13096-13099 DT denotes the
T5462 13086-13095 VB denotes stimulate
T5461 13083-13085 TO denotes To
T5460 13080-13081 -RRB- denotes ]
T5459 13078-13080 CD denotes 48
T5458 13077-13078 -LRB- denotes [
T5457 13072-13076 NN denotes mice
T5456 13063-13071 NN denotes knockout
T5455 13059-13062 NN denotes A20
T5454 13050-13058 JJ denotes specific
T5453 13045-13049 NN denotes cell
T5452 13037-13044 JJ denotes myeloid
T5451 13028-13036 VB denotes generate
T5450 13025-13027 TO denotes to
T5449 13022-13024 PRP denotes us
T5448 13014-13021 VB denotes allowed
T5447 13010-13013 CC denotes and
T5446 13004-13009 NN denotes cells
T5445 12996-13003 JJ denotes myeloid
T5279 10624-10625 -LRB- denotes (
T5278 10618-10623 NN denotes RIG-I
T5277 10607-10616 NN denotes construct
T5276 10598-10606 NN denotes reporter
T5275 10587-10597 NN denotes luciferase
T5274 10581-10586 NN denotes IFNα4
T5273 10567-10580 JJ denotes IRF7-specific
T5272 10564-10566 DT denotes an
T5271 10560-10563 CC denotes and
T5270 10556-10559 NN denotes A20
T5269 10554-10555 -COMMA- denotes ,
T5268 10553-10554 -RRB- denotes )
T5267 10548-10553 NN denotes 2CARD
T5266 10547-10548 -LRB- denotes (
T5265 10541-10546 NN denotes RIG-I
T5264 10532-10540 VB denotes encoding
T5263 10523-10531 NN denotes plasmids
T5262 10518-10522 IN denotes with
T5261 10509-10517 RB denotes together
T5260 10501-10508 NN denotes plasmid
T5259 10490-10500 NN denotes expression
T5258 10485-10489 NN denotes IRF7
T5257 10482-10484 DT denotes an
T5256 10479-10481 IN denotes of
T5255 10471-10478 NN denotes amounts
T5254 10465-10470 JJ denotes minor
T5253 10453-10464 VB denotes transfected
T5252 10443-10452 RB denotes therefore
T5251 10440-10442 PRP denotes we
T5250 10438-10439 -COMMA- denotes ,
T5249 10428-10438 NN denotes activation
T5248 10423-10427 NN denotes IRF7
T5247 10420-10422 IN denotes on
T5246 10416-10419 NN denotes A20
T5245 10413-10415 IN denotes of
T5244 10406-10412 NN denotes effect
T5243 10402-10405 DT denotes the
T5242 10392-10401 VB denotes determine
T5241 10389-10391 TO denotes To
T5240 10386-10387 -RRB- denotes ]
T5239 10384-10386 CD denotes 55
T5238 10383-10384 -LRB- denotes [
T5237 10381-10382 -COMMA- denotes ,
T5236 10380-10381 -RRB- denotes ]
T5235 10378-10380 CD denotes 54
T5234 10377-10378 -LRB- denotes [
T5233 10366-10376 NN denotes activation
T5232 10361-10365 NN denotes IRF3
T5231 10347-10360 JJ denotes virus-induced
T5230 10342-10346 IN denotes upon
T5229 10330-10341 VB denotes upregulated
T5228 10322-10329 RB denotes rapidly
T5227 10318-10321 VB denotes are
T5226 10311-10317 NN denotes levels
T5225 10303-10310 NN denotes protein
T5224 10298-10302 NN denotes IRF7
T5223 10294-10297 CC denotes and
T5222 10283-10293 NN denotes conditions
T5221 10277-10282 NN denotes naïve
T5220 10271-10276 IN denotes under
T5219 10261-10270 VB denotes expressed
T5218 10254-10260 RB denotes weakly
T5217 10251-10253 CC denotes or
T5216 10247-10250 RB denotes not
T5215 10244-10246 VB denotes is
T5214 10239-10243 NN denotes IRF7
T5213 10237-10238 -COMMA- denotes ,
T5212 10233-10237 NN denotes IRF3
T5211 10226-10232 IN denotes Unlike
T5210 10214-10224 NN denotes activation
T5209 10209-10213 NN denotes IRF7
T5208 10200-10208 VB denotes inhibits
T5207 10195-10199 RB denotes also
T5206 10191-10194 NN denotes A20
T5205 10183-10190 IN denotes whether
T5204 10170-10182 VB denotes investigated
T5203 10165-10169 RB denotes next
T5202 10162-10164 PRP denotes We
T5201 10159-10160 -RRB- denotes )
T5200 10154-10159 NN denotes graph
T5199 10147-10153 JJ denotes middle
T5198 10143-10146 CC denotes and
T5197 10138-10142 JJ denotes left
T5196 10136-10137 -COMMA- denotes ,
T5195 10134-10136 NN denotes 1A
T5194 10127-10133 NN denotes figure
T5193 10126-10127 -LRB- denotes (
T5192 10124-10125 -RRB- denotes ]
T5191 10123-10124 -RRB- denotes )
T5190 10118-10123 NN denotes 2CARD
T5189 10117-10118 -LRB- denotes (
T5188 10111-10116 NN denotes RIG-I
T5187 10110-10111 -LRB- denotes [
T5186 10104-10109 NN denotes RIG-I
T5185 10101-10103 IN denotes of
T5184 10093-10100 NN denotes domains
T5183 10088-10092 NN denotes CARD
T5182 10077-10087 JJ denotes N-terminal
T5181 10073-10076 CD denotes two
T5180 10069-10072 DT denotes the
T5179 10064-10068 RB denotes only
T5178 10061-10063 TO denotes to
T5177 10047-10060 VB denotes corresponding
T5176 10045-10046 -COMMA- denotes ,
T5175 10044-10045 -RRB- denotes ]
T5174 10042-10044 CD denotes 53
T5173 10041-10042 -LRB- denotes [
T5172 10035-10040 NN denotes RIG-I
T5171 10032-10034 IN denotes of
T5170 10027-10031 NN denotes form
T5169 10020-10026 JJ denotes active
T5168 10007-10019 JJ denotes constitutive
T5167 9997-10006 VB denotes truncated
T5166 9995-9996 DT denotes a
T5165 9992-9994 IN denotes of
T5164 9979-9991 NN denotes transfection
T5163 9976-9978 IN denotes by
T5162 9968-9975 VB denotes induced
T5161 9957-9967 NN denotes activation
T5160 9952-9956 NN denotes gene
T5159 9943-9951 NN denotes reporter
T5158 9932-9942 NN denotes luciferase
T5157 9917-9931 JJ denotes IRF3-dependent
T5156 9913-9916 CC denotes and
T5155 9906-9912 NN denotes NF-κB-
T5154 9897-9905 VB denotes prevents
T5153 9891-9896 NN denotes cells
T5152 9883-9890 NN denotes HEK293T
T5151 9880-9882 IN denotes in
T5150 9865-9879 NN denotes overexpression
T5149 9861-9864 NN denotes A20
T5148 9856-9860 IN denotes that
T5147 9851-9855 VB denotes show
T5146 9848-9850 PRP denotes we
T5145 9846-9847 -COMMA- denotes ,
T5144 9837-9846 RB denotes Similarly
T5143 9834-9835 -RRB- denotes ]
T5142 9832-9834 CD denotes 52
T5141 9831-9832 -LRB- denotes [
T5140 9830-9831 CD denotes –
T5139 9829-9830 -RRB- denotes ]
T5138 9827-9829 CD denotes 50
T5137 9826-9827 -LRB- denotes [
T5136 9814-9825 NN denotes stimulation
T5135 9808-9813 NN denotes RIG-I
T5134 9803-9807 IN denotes upon
T5133 9792-9802 NN denotes activation
T5132 9787-9791 NN denotes IRF3
T5131 9783-9786 CC denotes and
T5130 9777-9782 NN denotes NF-κB
T5129 9767-9776 VB denotes regulates
T5128 9756-9766 RB denotes negatively
T5127 9752-9755 NN denotes A20
T5126 9742-9751 VB denotes expressed
T5125 9730-9741 RB denotes ectopically
T5124 9725-9729 IN denotes that
T5123 9719-9724 VB denotes shown
T5122 9714-9718 VB denotes have
T5121 9706-9713 NN denotes studies
T5120 9697-9705 JJ denotes Previous
T5119 9684-9695 NN denotes propagation
T5118 9678-9683 JJ denotes viral
T5117 9670-9677 RB denotes further
T5116 9661-9669 VB denotes restrict
T5115 9656-9660 WDT denotes that
T5114 9651-9655 NN denotes IFNs
T5113 9649-9650 CD denotes I
T5112 9644-9648 NN denotes type
T5111 9640-9643 CC denotes and
T5110 9630-9639 NN denotes cytokines
T5109 9614-9629 JJ denotes proinflammatory
T5108 9611-9613 IN denotes of
T5107 9600-9610 NN denotes expression
T5106 9596-9599 DT denotes the
T5105 9588-9595 VB denotes promote
T5104 9582-9587 WDT denotes which
T5103 9580-9581 -COMMA- denotes ,
T5102 9573-9580 NN denotes factors
T5101 9559-9572 NN denotes transcription
T5100 9554-9558 NN denotes IRF7
T5099 9550-9553 CC denotes and
T5098 9545-9549 NN denotes IRF3
T5097 9543-9544 -COMMA- denotes ,
T5096 9538-9543 NN denotes NF-κB
T5095 9535-9537 IN denotes of
T5094 9524-9534 NN denotes activation
T5093 9520-9523 DT denotes the
T5092 9512-9519 VB denotes induces
T5091 9502-9511 NN denotes signaling
T5090 9496-9501 NN denotes RIG-I
T5847 15195-15206 NN denotes macrophages
T5846 15187-15194 JJ denotes primary
T5845 15184-15186 IN denotes in
T5844 15173-15183 NN denotes activation
T5843 15168-15172 NN denotes IRF3
T5842 15164-15167 CC denotes and
T5841 15158-15163 NN denotes NF-κB
T5840 15144-15157 JJ denotes RIG-I-induced
T5839 15141-15143 IN denotes of
T5838 15130-15140 NN denotes regulation
T5837 15121-15129 JJ denotes negative
T5836 15117-15120 DT denotes the
T5835 15114-15116 IN denotes in
T5834 15109-15113 NN denotes role
T5833 15099-15108 JJ denotes important
T5832 15096-15098 DT denotes an
T5831 15090-15095 VB denotes plays
T5830 15086-15089 NN denotes A20
T5829 15081-15085 IN denotes that
T5828 15069-15080 VB denotes demonstrate
T5827 15061-15068 NN denotes results
T5826 15055-15060 DT denotes these
T5825 15053-15054 -COMMA- denotes ,
T5824 15045-15053 RB denotes Together
T5823 15042-15043 -RRB- denotes )
T5822 15037-15042 VB denotes shown
T5821 15033-15036 RB denotes not
T5820 15028-15032 NN denotes data
T5819 15027-15028 -LRB- denotes (
T5818 15015-15026 NN denotes macrophages
T5817 15004-15014 JJ denotes peritoneal
T5816 14998-15003 VB denotes using
T5815 14989-14997 VB denotes obtained
T5814 14984-14988 VB denotes were
T5813 14976-14983 NN denotes results
T5812 14968-14975 JJ denotes Similar
T5811 14965-14966 -RRB- denotes )
T5810 14963-14965 NN denotes 1D
T5809 14956-14962 NN denotes figure
T5808 14955-14956 -LRB- denotes (
T5807 14950-14954 NN denotes IFNβ
T5806 14946-14949 CC denotes and
T5805 14942-14945 NN denotes TNF
T5804 14940-14941 -COMMA- denotes ,
T5803 14936-14940 NN denotes IL-6
T5802 14933-14935 IN denotes of
T5801 14925-14932 NN denotes amounts
T5800 14915-14924 VB denotes increased
T5799 14906-14914 VB denotes secreted
T5798 14901-14905 NN denotes BMDM
T5797 14890-14900 NN denotes A20myel-KO
T5796 14888-14889 -COMMA- denotes ,
T5795 14883-14888 IN denotes above
T5794 14873-14882 VB denotes described
T5793 14870-14872 IN denotes as
T5792 14865-14869 NN denotes IRF3
T5791 14861-14864 CC denotes and
T5790 14855-14860 NN denotes NF-κB
T5789 14852-14854 IN denotes of
T5788 14841-14851 NN denotes activation
T5787 14832-14840 VB denotes enhanced
T5786 14828-14831 DT denotes the
T5785 14823-14827 IN denotes with
T5784 14818-14822 NN denotes line
T5783 14815-14817 IN denotes In
T5782 14809-14813 NN denotes IFNβ
T5781 14806-14808 IN denotes of
T5780 14795-14805 NN denotes expression
T5779 14791-14794 DT denotes the
T5778 14783-14790 VB denotes control
T5777 14778-14782 NN denotes IRF3
T5776 14774-14777 CC denotes and
T5775 14768-14773 NN denotes NF-κB
T5774 14764-14767 CC denotes and
T5773 14762-14763 -COMMA- denotes ,
T5772 14759-14762 NN denotes TNF
T5771 14755-14758 CC denotes and
T5770 14750-14754 NN denotes IL-6
T5769 14747-14749 IN denotes of
T5768 14736-14746 NN denotes expression
T5767 14732-14735 DT denotes the
T5766 14723-14731 VB denotes controls
T5765 14717-14722 NN denotes NF-κB
T5764 14714-14715 -RRB- denotes )
T5763 14712-14714 NN denotes 1C
T5762 14705-14711 NN denotes figure
T5761 14704-14705 -LRB- denotes (
T5760 14698-14703 NN denotes cells
T5759 14693-14697 NN denotes type
T5758 14688-14692 JJ denotes wild
T5757 14685-14687 TO denotes to
T5756 14676-14684 VB denotes compared
T5755 14671-14675 NN denotes BMDM
T5754 14661-14670 JJ denotes deficient
T5753 14657-14660 NN denotes A20
T5752 14654-14656 IN denotes in
T5751 14648-14653 NN denotes point
T5750 14643-14647 NN denotes time
T5749 14635-14642 JJ denotes earlier
T5748 14632-14634 DT denotes an
T5747 14629-14631 IN denotes at
T5746 14621-14628 NN denotes maximum
T5745 14617-14620 PRP-DOLLAR- denotes its
T5744 14609-14616 VB denotes reached
T5743 14595-14608 NN denotes translocation
T5742 14587-14594 JJ denotes nuclear
T5741 14582-14586 NN denotes IRF3
T5740 14580-14581 -COMMA- denotes ,
T5739 14577-14580 NN denotes p65
T5738 14574-14576 TO denotes to
T5737 14566-14573 JJ denotes Similar
T5736 14563-14564 -RRB- denotes )
T5735 14561-14563 NN denotes 1B
T5734 14554-14560 NN denotes figure
T5733 14553-14554 -LRB- denotes (
T5732 14548-14552 NN denotes BMDM
T5731 14543-14547 NN denotes type
T5730 14538-14542 JJ denotes wild
T5729 14535-14537 TO denotes to
T5728 14526-14534 VB denotes compared
T5727 14521-14525 NN denotes BMDM
T5726 14510-14520 NN denotes A20myel-KO
T5725 14507-14509 IN denotes in
T5724 14500-14506 NN denotes points
T5723 14495-14499 NN denotes time
T5722 14487-14494 JJ denotes earlier
T5721 14484-14486 IN denotes at
T5720 14475-14483 VB denotes detected
T5719 14471-14474 VB denotes was
T5718 14455-14470 NN denotes phosphorylation
T5717 14450-14454 NN denotes IRF3
T5716 14442-14449 JJ denotes maximum
T5715 14440-14441 -COMMA- denotes ,
T5714 14434-14440 NN denotes Ser396
T5713 14419-14433 VB denotes phosphorylated
T5712 14411-14418 IN denotes against
T5711 14402-14410 VB denotes directed
T5710 14393-14401 NN denotes antibody
T5709 14390-14392 DT denotes an
T5708 14385-14389 IN denotes with
T5707 14370-14384 NN denotes immunoblotting
T5706 14364-14369 VB denotes Using
T5705 14361-14362 -RRB- denotes ]
T5704 14359-14361 CD denotes 59
T5703 14358-14359 -LRB- denotes [
T5702 14350-14357 NN denotes nucleus
T5701 14346-14349 DT denotes the
T5700 14343-14345 TO denotes to
T5699 14329-14342 NN denotes translocation
T5698 14318-14328 JJ denotes subsequent
T5697 14314-14317 CC denotes and
T5696 14301-14313 NN denotes dimerization
T5695 14297-14300 PRP-DOLLAR- denotes its
T5694 14294-14296 TO denotes to
T5693 14286-14293 VB denotes leading
T5692 14284-14285 -COMMA- denotes ,
T5691 14283-14284 -RRB- denotes ]
T5690 14281-14283 CD denotes 58
T5689 14280-14281 -LRB- denotes [
T5688 14275-14279 NN denotes IKKε
T5687 14271-14274 CC denotes and
T5686 14266-14270 NN denotes TBK1
T5685 14258-14265 NN denotes kinases
T5684 14249-14257 JJ denotes IKK-like
T5683 14245-14248 DT denotes the
T5682 14242-14244 IN denotes by
T5681 14233-14241 NN denotes residues
T5680 14226-14232 NN denotes serine
T5679 14217-14225 JJ denotes terminal
T5678 14208-14216 NN denotes carboxyl
T5677 14205-14207 IN denotes of
T5676 14198-14204 NN denotes series
T5675 14196-14197 DT denotes a
T5674 14193-14195 IN denotes of
T5673 14177-14192 NN denotes phosphorylation
T5672 14172-14176 IN denotes upon
T5671 14162-14171 VB denotes activated
T5670 14159-14161 VB denotes be
T5669 14156-14158 TO denotes to
T5668 14150-14155 VB denotes known
T5667 14147-14149 VB denotes is
T5666 14142-14146 NN denotes IRF3
T5665 14139-14140 -RRB- denotes )
T5664 14137-14139 NN denotes 1C
T5663 14130-14136 NN denotes figure
T5662 14129-14130 -LRB- denotes (
T5661 14123-14128 NN denotes cells
T5089 9485-9495 NN denotes activation
T5088 9480-9484 NN denotes IRF3
T5087 9476-9479 CC denotes and
T5086 9470-9475 NN denotes NF-κB
T5085 9456-9469 JJ denotes RIG-I-induced
T5084 9447-9455 VB denotes inhibits
T5083 9443-9446 NN denotes A20
T5444 12993-12995 IN denotes in
T5443 12984-12992 NN denotes deletion
T5442 12975-12983 JJ denotes specific
T5441 12972-12974 TO denotes to
T5440 12966-12971 VB denotes leads
T5439 12957-12965 NN denotes promoter
T5438 12955-12956 NN denotes M
T5437 12946-12954 NN denotes lysozyme
T5436 12942-12945 DT denotes the
T5435 12939-12941 IN denotes of
T5434 12931-12938 NN denotes control
T5433 12925-12930 IN denotes under
T5432 12913-12924 NN denotes recombinase
T5431 12909-12912 NNP denotes Cre
T5430 12898-12908 VB denotes expressing
T5429 12893-12897 NN denotes mice
T5428 12882-12892 JJ denotes transgenic
T5427 12877-12881 IN denotes with
T5426 12872-12876 NN denotes mice
T5425 12866-12871 DT denotes these
T5424 12857-12865 VB denotes Crossing
T5423 12854-12855 -RRB- denotes ]
T5422 12852-12854 CD denotes 56
T5421 12851-12852 -LRB- denotes [
T5420 12845-12850 NN denotes sites
T5419 12840-12844 NN denotes loxP
T5418 12836-12839 CD denotes two
T5417 12833-12835 IN denotes by
T5416 12825-12832 VB denotes flanked
T5415 12820-12824 VB denotes were
T5414 12818-12819 CD denotes V
T5413 12813-12817 NN denotes exon
T5412 12809-12812 CC denotes and
T5411 12806-12808 CD denotes IV
T5410 12801-12805 NN denotes exon
T5409 12795-12800 WDT denotes which
T5408 12792-12794 IN denotes in
T5407 12785-12791 NN denotes allele
T5406 12781-12784 NN denotes A20
T5405 12769-12780 JJ denotes conditional
T5404 12767-12768 DT denotes a
T5403 12758-12766 VB denotes carrying
T5402 12753-12757 NN denotes mice
T5401 12743-12752 VB denotes generated
T5400 12740-12742 PRP denotes we
T5399 12738-12739 -COMMA- denotes ,
T5398 12737-12738 -RRB- denotes ]
T5397 12735-12737 CD denotes 37
T5396 12734-12735 -LRB- denotes [
T5395 12721-12733 NN denotes inflammation
T5394 12709-12720 JJ denotes multi-organ
T5393 12702-12708 JJ denotes severe
T5392 12699-12701 IN denotes of
T5391 12692-12698 NN denotes result
T5390 12690-12691 DT denotes a
T5389 12687-12689 IN denotes as
T5388 12675-12686 RB denotes prematurely
T5387 12671-12674 VB denotes die
T5386 12666-12670 NN denotes mice
T5385 12657-12665 NN denotes knockout
T5384 12652-12656 JJ denotes full
T5383 12648-12651 NN denotes A20
T5382 12642-12647 IN denotes Since
T5381 12629-12640 NN denotes macrophages
T5380 12621-12628 JJ denotes primary
T5379 12611-12620 JJ denotes deficient
T5378 12607-12610 NN denotes A20
T5377 12604-12606 IN denotes in
T5376 12592-12603 NN denotes experiments
T5375 12584-12591 JJ denotes further
T5374 12574-12583 VB denotes performed
T5373 12571-12573 PRP denotes we
T5372 12569-12570 -COMMA- denotes ,
T5371 12562-12569 NN denotes context
T5370 12553-12561 JJ denotes relevant
T5369 12539-12552 JJ denotes immunological
T5368 12534-12538 RB denotes more
T5367 12532-12533 DT denotes a
T5366 12529-12531 IN denotes in
T5365 12519-12528 NN denotes signaling
T5364 12505-12518 JJ denotes RIG-I-induced
T5363 12502-12504 IN denotes on
T5362 12498-12501 NN denotes A20
T5361 12488-12497 VB denotes expressed
T5360 12475-12487 RB denotes endogenously
T5359 12472-12474 IN denotes of
T5358 12465-12471 NN denotes effect
T5357 12461-12464 DT denotes the
T5356 12455-12460 VB denotes study
T5355 12452-12454 TO denotes To
T5354 11070-11080 NN denotes activation
T5353 11063-11069 NN denotes IRF3/7
T5352 11059-11062 CC denotes and
T5351 11053-11058 NN denotes NF-κB
T5350 11039-11052 JJ denotes RIG-I-induced
T5349 11031-11038 VB denotes inhibit
T5348 11028-11030 TO denotes to
T5347 11024-11027 NN denotes A20
T5346 11021-11023 IN denotes of
T5345 11011-11020 NN denotes potential
T5344 11007-11010 DT denotes the
T5343 10995-11006 VB denotes demonstrate
T5342 10987-10994 NN denotes results
T5341 10981-10986 DT denotes These
T5340 10978-10979 -RRB- denotes )
T5339 10973-10978 NN denotes graph
T5338 10967-10972 JJ denotes right
T5337 10965-10966 -COMMA- denotes ,
T5336 10963-10965 NN denotes 1A
T5335 10956-10962 NN denotes figure
T5334 10955-10956 -LRB- denotes (
T5333 10944-10954 NN denotes activation
T5332 10939-10943 NN denotes IRF7
T5331 10925-10938 JJ denotes RIG-I-induced
T5330 10915-10924 VB denotes prevented
T5329 10910-10914 RB denotes also
T5328 10906-10909 NN denotes A20
T5327 10904-10905 -COMMA- denotes ,
T5326 10894-10904 NN denotes activation
T5325 10889-10893 NN denotes IRF3
T5324 10885-10888 CC denotes and
T5323 10879-10884 NN denotes NF-κB
T5322 10876-10878 IN denotes on
T5321 10869-10875 NN denotes effect
T5320 10858-10868 JJ denotes inhibitory
T5319 10854-10857 PRP-DOLLAR- denotes its
T5318 10851-10853 TO denotes to
T5317 10843-10850 JJ denotes Similar
T5316 10837-10841 NN denotes IRF7
T5315 10834-10836 IN denotes of
T5314 10825-10833 NN denotes presence
T5313 10821-10824 DT denotes the
T5312 10818-10820 IN denotes in
T5311 10809-10817 VB denotes observed
T5310 10805-10808 VB denotes was
T5309 10794-10804 NN denotes expression
T5308 10789-10793 NN denotes gene
T5307 10780-10788 NN denotes reporter
T5306 10768-10779 JJ denotes significant
T5305 10760-10767 IN denotes whereas
T5304 10758-10759 -COMMA- denotes ,
T5303 10757-10758 -RRB- denotes )
T5302 10752-10757 NN denotes graph
T5301 10746-10751 JJ denotes right
T5300 10744-10745 -COMMA- denotes ,
T5299 10742-10744 NN denotes 1A
T5298 10735-10741 NN denotes figure
T5297 10733-10734 -COMMA- denotes ,
T5296 10730-10733 NN denotes bar
T5295 10725-10729 JJ denotes grey
T5294 10724-10725 -LRB- denotes (
T5293 10713-10723 NN denotes activation
T5292 10704-10712 NN denotes promoter
T5291 10698-10703 NN denotes IFNα4
T5290 10687-10697 JJ denotes negligible
T5289 10680-10686 VB denotes showed
T5288 10666-10679 NN denotes co-expression
T5287 10661-10665 NN denotes IRF7
T5286 10658-10660 IN denotes of
T5285 10650-10657 NN denotes absence
T5284 10646-10649 DT denotes the
T5283 10643-10645 IN denotes in
T5282 10632-10642 NN denotes expression
T5281 10630-10631 -RRB- denotes )
T5280 10625-10630 NN denotes 2CARD
T2150 7503-7504 CD denotes I
T2149 7494-7502 NN denotes receptor
T2148 7490-7493 NN denotes TNF
T2147 7487-7489 IN denotes as
T2146 7482-7486 JJ denotes such
T2145 7472-7481 NN denotes receptors
T2144 7463-7471 JJ denotes multiple
T2143 7460-7462 TO denotes to
T2142 7451-7459 NN denotes response
T2141 7448-7450 IN denotes in
T2140 7444-7447 NN denotes A20
T2139 7441-7443 IN denotes by
T2138 7431-7440 NN denotes signaling
T2137 7415-7430 JJ denotes proinflammatory
T2136 7412-7414 IN denotes of
T2135 7401-7411 NN denotes regulation
T2134 7392-7400 JJ denotes negative
T2133 7388-7391 DT denotes the
T2132 7385-7387 IN denotes in
T2131 7376-7384 VB denotes involved
T2130 7373-7375 VB denotes be
T2129 7370-7372 TO denotes to
T2128 7364-7369 VB denotes shown
T2127 7353-7363 RB denotes previously
T2126 7348-7352 VB denotes were
T2125 7337-7347 NN denotes mechanisms
T2124 7324-7336 JJ denotes noncatalytic
T2123 7320-7323 CC denotes and
T2122 7310-7319 JJ denotes catalytic
T2121 7305-7309 CC denotes Both
T2120 7295-7303 NN denotes activity
T2119 7288-7294 NN denotes ligase
T2118 7278-7287 NN denotes ubiquitin
T2117 7275-7277 NN denotes E3
T2116 7262-7274 JJ denotes K48-specific
T2115 7252-7261 JJ denotes dependent
T2114 7245-7251 NN denotes finger
T2113 7240-7244 NN denotes zinc
T2112 7231-7239 JJ denotes atypical
T2111 7223-7230 VB denotes harbors
T2110 7218-7222 RB denotes also
T2109 7214-7217 NN denotes A20
T2108 7212-7213 -COMMA- denotes ,
T2107 7199-7212 RB denotes Interestingly
T2106 7193-7197 NN denotes DUBs
T2105 7190-7192 IN denotes of
T2104 7183-7189 NN denotes family
T2103 7172-7182 NN denotes OTU-domain
T2102 7168-7171 DT denotes the
T2101 7165-7167 TO denotes to
T2100 7155-7164 VB denotes belonging
T2099 7148-7154 NN denotes enzyme
T2098 7130-7147 JJ denotes ubiquitin-editing
T2097 7127-7129 DT denotes an
T2096 7124-7126 VB denotes is
T2095 7120-7123 NN denotes A20
T2094 7106-7118 NN denotes transduction
T2093 7099-7105 NN denotes signal
T2092 7089-7098 JJ denotes antiviral
T2091 7081-7088 VB denotes dampens
T2090 7073-7080 RB denotes further
T2089 7071-7072 -RRB- denotes ]
T2088 7069-7071 CD denotes 36
T2087 7068-7069 -LRB- denotes [
T2086 7062-7067 NN denotes RBCK1
T2085 7058-7061 CC denotes and
T2084 7056-7057 -RRB- denotes ]
T2083 7054-7056 CD denotes 35
T2082 7053-7054 -LRB- denotes [
T2081 7046-7052 NN denotes TRIM21
T2080 7044-7045 -COMMA- denotes ,
T2079 7043-7044 -RRB- denotes ]
T2078 7041-7043 CD denotes 34
T2077 7040-7041 -LRB- denotes [
T2076 7035-7039 NN denotes RAUL
T2075 7032-7034 IN denotes as
T2074 7027-7031 JJ denotes such
T2073 7023-7026 NN denotes E3s
T2072 7020-7022 IN denotes by
T2071 7012-7019 NN denotes factors
T2070 6998-7011 NN denotes transcription
T2069 6993-6997 NN denotes IRF7
T2068 6989-6992 CC denotes and
T2067 6984-6988 NN denotes IRF3
T2066 6980-6983 DT denotes the
T2065 6977-6979 TO denotes to
T2064 6970-6976 NN denotes chains
T2063 6956-6969 NN denotes polyubiquitin
T2062 6943-6955 JJ denotes K48-specific
T2061 6940-6942 IN denotes of
T2060 6929-6939 NN denotes attachment
T2059 6925-6928 DT denotes the
T2058 6923-6924 -COMMA- denotes ,
T2057 6911-6923 RB denotes Additionally
T2056 6900-6909 NN denotes signaling
T2055 6889-6899 JJ denotes downstream
T2054 6881-6888 JJ denotes further
T2053 6870-6880 VB denotes inhibiting
T2052 6865-6869 RB denotes thus
T2051 6863-6864 -COMMA- denotes ,
T2050 6852-6863 NN denotes degradation
T2049 6843-6851 VB denotes mediated
T2048 6832-6842 NN denotes proteasome
T2047 6828-6831 IN denotes for
T2046 6822-6827 NN denotes TRAF3
T2045 6818-6821 CC denotes and
T2044 6813-6817 NN denotes MAVS
T2043 6800-6812 RB denotes respectively
T2042 6795-6799 NN denotes mark
T2041 6793-6794 -RRB- denotes ]
T2040 6791-6793 CD denotes 33
T2039 6790-6791 -LRB- denotes [
T2038 6782-6789 NN denotes TRIAD3A
T2037 6778-6781 CC denotes and
T2036 6776-6777 -RRB- denotes ]
T2035 6774-6776 CD denotes 32
T2034 6773-6774 -LRB- denotes [
T2033 6768-6772 NN denotes AIP4
T2032 6765-6767 IN denotes as
T2031 6760-6764 JJ denotes such
T2030 6758-6759 -COMMA- denotes ,
T2029 6751-6758 NN denotes ligases
T2028 6741-6750 NN denotes ubiquitin
T2027 6728-6740 JJ denotes K48-specific
T2026 6720-6727 JJ denotes various
T2025 6718-6719 -COMMA- denotes ,
T2024 6707-6718 RB denotes Furthermore
T2023 6696-6705 NN denotes molecules
T2022 6686-6695 VB denotes signaling
T2021 6678-6685 JJ denotes several
T2020 6673-6677 IN denotes from
T2019 6666-6672 NN denotes chains
T2018 6652-6665 NN denotes polyubiquitin
T2017 6641-6651 JJ denotes K63-linked
T2016 6632-6640 VB denotes removing
T2015 6619-6631 RB denotes specifically
T2014 6616-6618 IN denotes by
T2013 6606-6615 NN denotes signaling
T2012 6602-6605 NN denotes RLR
T2011 6593-6601 VB denotes regulate
T2010 6582-6592 RB denotes negatively
T2009 6579-6581 TO denotes to
T2008 6573-6578 VB denotes shown
T2007 6568-6572 VB denotes been
T2006 6563-6567 VB denotes have
T2005 6561-6562 -RRB- denotes ]
T2004 6559-6561 CD denotes 31
T2003 6558-6559 -LRB- denotes [
T2002 6550-6557 NN denotes OTUB1/2
T2001 6546-6549 CC denotes and
T2000 6544-6545 -RRB- denotes ]
T1998 6541-6542 -LRB- denotes [
T1997 6539-6540 -COMMA- denotes ,
T1996 6538-6539 -RRB- denotes ]
T1995 6536-6538 CD denotes 29
T1994 6535-6536 -LRB- denotes [
T1993 6530-6534 NN denotes CYLD
T1992 6528-6529 -COMMA- denotes ,
T1991 6527-6528 -RRB- denotes ]
T1990 6525-6527 CD denotes 28
T1989 6524-6525 -LRB- denotes [
T1988 6519-6523 NNP denotes DUBA
T1987 6516-6518 IN denotes as
T1986 6511-6515 JJ denotes such
T1985 6509-6510 -COMMA- denotes ,
T1984 6508-6509 -RRB- denotes )
T1983 6504-6508 NN denotes DUBs
T1982 6503-6504 -LRB- denotes (
T1981 6495-6502 NN denotes enzymes
T1980 6478-6494 VB denotes deubiquitinating
T1979 6476-6477 -COMMA- denotes ,
T1978 6472-6476 NN denotes hand
T1977 6466-6471 JJ denotes other
T1976 6462-6465 DT denotes the
T1975 6459-6461 IN denotes On
T1974 6446-6457 NN denotes stimulation
T1973 6440-6445 NN denotes RIG-I
T1972 6435-6439 IN denotes upon
T1971 6424-6434 NN denotes activation
T1970 6419-6423 NN denotes IRF3
T1969 6415-6418 CC denotes and
T1968 6409-6414 NN denotes NF-κB
T1967 6396-6408 RB denotes respectively
T1966 6388-6395 VB denotes mediate
T1965 6386-6387 -RRB- denotes ]
T1964 6384-6386 CD denotes 27
T1963 6383-6384 -LRB- denotes [
T1962 6377-6382 NN denotes TRAF3
T1961 6373-6376 CC denotes and
T1960 6371-6372 -RRB- denotes ]
T1959 6369-6371 CD denotes 26
T1958 6368-6369 -LRB- denotes [
T1957 6366-6367 -COMMA- denotes ,
T1956 6365-6366 -RRB- denotes ]
T1955 6363-6365 CD denotes 25
T1954 6362-6363 -LRB- denotes [
T1953 6356-6361 NN denotes TRAF6
T1952 6353-6355 IN denotes as
T1951 6348-6352 JJ denotes such
T1950 6340-6347 NN denotes ligases
T1949 6330-6339 NN denotes ubiquitin
T1948 6316-6329 VB denotes characterized
T1947 6311-6315 RB denotes well
T1946 6309-6310 -COMMA- denotes ,
T1945 6301-6309 NN denotes addition
T1944 6298-6300 IN denotes In
T1943 6286-6296 NN denotes activation
T1942 6280-6285 NN denotes RIG-I
T1941 6272-6279 VB denotes promote
T1940 6263-6271 RB denotes directly
T1939 6260-6262 TO denotes to
T1938 6254-6259 VB denotes shown
T1937 6249-6253 VB denotes been
T1936 6244-6248 VB denotes have
T1935 6242-6243 -COMMA- denotes ,
T1920 6201-6205 JJ denotes such
T1919 6199-6200 -COMMA- denotes ,
T1918 6198-6199 -RRB- denotes )
T1917 6195-6198 NN denotes E3s
T1916 6194-6195 -LRB- denotes (
T1915 6186-6193 NN denotes ligases
T1914 6176-6185 NN denotes ubiquitin
T1913 6163-6175 JJ denotes K63-specific
T1912 6160-6161 -RRB- denotes ]
T1911 6158-6160 CD denotes 21
T1910 6157-6158 -LRB- denotes [
T1909 6144-6156 NN denotes transduction
T1908 6137-6143 NN denotes signal
T1907 6128-6136 JJ denotes mediated
T1906 6122-6127 NN denotes RIG-I
T1905 6113-6121 VB denotes regulate
T1904 6102-6112 RB denotes negatively
T1903 6098-6101 CC denotes and
T1902 6087-6097 RB denotes positively
T1901 6082-6086 CC denotes both
T1900 6076-6081 WDT denotes which
T1899 6074-6075 -COMMA- denotes ,
T1898 6067-6074 NN denotes enzymes
T1897 6057-6066 VB denotes modifying
T1896 6047-6056 NN denotes ubiquitin
T1895 6039-6046 JJ denotes various
T1894 6036-6038 IN denotes of
T1893 6029-6035 NN denotes action
T1892 6025-6028 DT denotes the
T1891 6016-6024 VB denotes requires
T1890 6011-6015 NN denotes MAVS
T1889 6008-6010 IN denotes of
T1888 5997-6007 RB denotes downstream
T1887 5987-5996 VB denotes Signaling
T1886 5984-5985 -RRB- denotes ]
T1885 5982-5984 CD denotes 20
T1884 5981-5982 -LRB- denotes [
T1883 5980-5981 CD denotes –
T1882 5979-5980 -RRB- denotes ]
T1881 5977-5979 CD denotes 17
T1880 5976-5977 -LRB- denotes [
T1879 5969-5975 NN denotes domain
T1878 5955-5968 NN denotes transmembrane
T1877 5944-5954 JJ denotes C-terminal
T1876 5940-5943 PRP-DOLLAR- denotes its
T1875 5936-5939 IN denotes via
T1874 5927-5935 NN denotes membrane
T1873 5913-5926 JJ denotes mitochondrial
T1872 5907-5912 JJ denotes outer
T1871 5903-5906 DT denotes the
T1870 5900-5902 IN denotes in
T1869 5892-5899 NN denotes inserts
T1868 5888-5891 CC denotes and
T1867 5885-5887 TO denotes to
T1866 5872-5884 VB denotes translocates
T1865 5859-5871 RB denotes subsequently
T1864 5853-5858 WDT denotes which
T1863 5851-5852 -COMMA- denotes ,
T1862 5844-5851 NN denotes protein
T1861 5836-5843 NN denotes adaptor
T1860 5834-5835 -RRB- denotes )
T1859 5828-5834 NNP denotes Cardif
T1858 5826-5827 -COMMA- denotes ,
T1857 5822-5826 NN denotes VISA
T1856 5820-5821 -COMMA- denotes ,
T1855 5815-5820 NN denotes IPS-1
T1854 5808-5814 VB denotes termed
T1853 5803-5807 RB denotes also
T1852 5802-5803 -LRB- denotes (
T1851 5797-5801 NN denotes MAVS
T1850 5793-5796 DT denotes the
T1849 5790-5792 IN denotes of
T1848 5783-5789 NN denotes domain
T1847 5778-5782 NN denotes CARD
T1846 5774-5777 DT denotes the
T1845 5769-5773 IN denotes with
T1844 5759-5768 VB denotes associate
T1843 5753-5758 NN denotes RIG-I
T1842 5750-5752 IN denotes of
T1841 5742-5749 NN denotes domains
T1840 5737-5741 NN denotes CARD
T1839 5733-5736 DT denotes the
T1838 5731-5732 -COMMA- denotes ,
T1837 5724-5731 NN denotes binding
T1836 5717-5723 NN denotes ligand
T1835 5712-5716 IN denotes Upon
T1834 5703-5710 NN denotes domains
T1833 5698-5702 NN denotes CARD
T1832 5687-5697 JJ denotes N-terminal
T1831 5683-5686 CD denotes two
T1830 5679-5682 CC denotes and
T1829 5677-5678 -COMMA- denotes ,
T1828 5666-5677 NN denotes recognition
T1827 5659-5665 NN denotes ligand
T1826 5655-5658 IN denotes for
T1825 5646-5654 VB denotes required
T1824 5643-5645 VB denotes is
T1823 5637-5642 WDT denotes which
T1822 5635-5636 -COMMA- denotes ,
T1821 5629-5635 NN denotes domain
T1820 5620-5628 NN denotes helicase
T1819 5616-5619 NN denotes box
T1818 5609-5615 NN denotes DExD/H
T1817 5598-5608 JJ denotes C-terminal
T1816 5596-5597 DT denotes a
T1815 5587-5595 VB denotes contains
T1814 5581-5586 NN denotes RIG-I
T1813 5570-5579 NN denotes influenza
T1812 5567-5569 IN denotes of
T1811 5554-5566 NN denotes pathogenesis
T1810 5550-5553 DT denotes the
T1809 5547-5549 TO denotes to
T1808 5536-5546 VB denotes contribute
T1807 5533-5535 TO denotes to
T1806 5526-5532 JJ denotes likely
T1805 5523-5525 VB denotes is
T1804 5517-5522 NN denotes cells
T1803 5510-5516 JJ denotes immune
T1802 5507-5509 IN denotes by
T1801 5498-5506 VB denotes released
T1800 5488-5497 NN denotes mediators
T1799 5485-5487 IN denotes of
T1798 5477-5484 NN denotes effects
T1797 5469-5476 JJ denotes harmful
T1796 5465-5468 CC denotes and
T1795 5454-5464 JJ denotes beneficial
T1794 5450-5453 DT denotes the
T1793 5442-5449 IN denotes between
T1792 5432-5441 NN denotes imbalance
T1791 5429-5431 DT denotes an
T1790 5424-5428 IN denotes that
T1789 5415-5423 VB denotes indicate
T1788 5407-5414 NN denotes results
T1787 5401-5406 DT denotes These
T1786 5398-5399 -RRB- denotes ]
T1785 5396-5398 CD denotes 16
T1784 5395-5396 -LRB- denotes [
T1783 5385-5394 NN denotes infection
T1782 5379-5384 JJ denotes acute
T1781 5376-5378 TO denotes to
T1780 5366-5375 NN denotes advantage
T1779 5357-5365 NN denotes survival
T1778 5355-5356 DT denotes a
T1777 5350-5354 VB denotes have
T1776 5345-5349 NN denotes mice
T1775 5335-5344 JJ denotes deficient
T1774 5330-5334 NN denotes TLR3
T1773 5322-5329 IN denotes whereas
T1772 5320-5321 -COMMA- denotes ,
T1771 5319-5320 -RRB- denotes ]
T1770 5317-5319 CD denotes 15
T1769 5316-5317 -LRB- denotes [
T1768 5314-5315 -COMMA- denotes ,
T1767 5313-5314 -RRB- denotes ]
T1766 5311-5313 CD denotes 14
T1765 5310-5311 -LRB- denotes [
T1764 5306-5309 NN denotes IAV
T1763 5303-5305 TO denotes to
T1762 5291-5302 JJ denotes susceptible
T1761 5284-5290 RB denotes highly
T1760 5280-5283 VB denotes are
T1759 5275-5279 NN denotes mice
T1758 5265-5274 JJ denotes deficient
T1757 5259-5264 NN denotes RIG-I
T1756 5257-5258 -COMMA- denotes ,
T1755 5244-5257 RB denotes Interestingly
T1754 5241-5242 -RRB- denotes ]
T1753 5239-5241 CD denotes 13
T1752 5238-5239 -LRB- denotes [
T1751 5228-5237 NN denotes signaling
T1750 5219-5227 VB denotes mediated
T1749 5213-5218 NN denotes RIG-I
T1748 5210-5212 IN denotes on
T1747 5202-5209 VB denotes depends
T1746 5194-5201 RB denotes largely
T1745 5185-5193 NN denotes response
T1744 5178-5184 JJ denotes immune
T1743 5168-5177 JJ denotes antiviral
T1742 5161-5167 JJ denotes innate
T1741 5157-5160 DT denotes the
T1740 5154-5156 IN denotes of
T1739 5143-5153 NN denotes initiation
T1738 5139-5142 DT denotes the
T1737 5135-5138 CC denotes but
T1736 5133-5134 -COMMA- denotes ,
T1735 5130-5133 NN denotes IAV
T1734 5127-5129 TO denotes to
T1733 5118-5126 NN denotes response
T1732 5102-5117 JJ denotes proinflammatory
T1731 5098-5101 DT denotes the
T2477 9422-9431 NN denotes potential
T2476 9410-9421 JJ denotes therapeutic
T2475 9405-9409 VB denotes have
T2474 9399-9404 MD denotes might
T2473 9393-9398 NN denotes cells
T2472 9385-9392 JJ denotes myeloid
T2471 9382-9384 IN denotes in
T2470 9373-9381 NN denotes activity
T2469 9369-9372 NN denotes A20
T2468 9359-9368 VB denotes targeting
T2467 9356-9358 IN denotes by
T2466 9352-9355 NN denotes IAV
T2465 9349-9351 TO denotes to
T2464 9340-9348 NN denotes response
T2463 9333-9339 JJ denotes immune
T2462 9326-9332 JJ denotes innate
T2461 9322-9325 DT denotes the
T2460 9313-9321 VB denotes boosting
T2459 9308-9312 IN denotes that
T2458 9300-9307 VB denotes suggest
T2457 9292-9299 NN denotes results
T2456 9286-9291 DT denotes These
T2455 9275-9284 NN denotes clearance
T2454 9269-9274 JJ denotes viral
T2453 9260-9268 VB denotes enhanced
T2452 9256-9259 CC denotes and
T2451 9254-9255 -COMMA- denotes ,
T2450 9243-9254 NN denotes macrophages
T2449 9234-9242 JJ denotes alveolar
T2448 9230-9233 CC denotes and
T2447 9219-9229 NN denotes neutophils
T2446 9216-9218 IN denotes as
T2445 9211-9215 JJ denotes such
T2444 9205-9210 NN denotes cells
T2443 9198-9204 JJ denotes immune
T2442 9191-9197 JJ denotes innate
T2441 9188-9190 IN denotes of
T2440 9176-9187 NN denotes recruitment
T2439 9166-9175 VB denotes augmented
T2438 9164-9165 -COMMA- denotes ,
T2437 9154-9164 NN denotes production
T2436 9144-9153 NN denotes chemokine
T2435 9140-9143 CC denotes and
T2434 9131-9139 NN denotes cytokine
T2433 9121-9130 VB denotes increased
T2432 9116-9120 IN denotes with
T2431 9105-9115 VB denotes associated
T2430 9102-9104 VB denotes is
T2429 9097-9101 NN denotes mice
T2428 9086-9096 NN denotes A20myel-KO
T2427 9083-9085 IN denotes in
T2426 9079-9082 NN denotes IAV
T2425 9071-9078 IN denotes against
T2424 9060-9070 NN denotes Protection
T2423 9054-9058 NN denotes mice
T2422 9049-9053 NN denotes type
T2421 9044-9048 JJ denotes wild
T2420 9041-9043 TO denotes to
T2419 9032-9040 VB denotes compared
T2418 9022-9031 NN denotes infection
T2417 9017-9021 NN denotes lung
T2416 9013-9016 NN denotes IAV
T2415 9010-9012 TO denotes to
T2414 9001-9009 NN denotes response
T2413 8998-9000 IN denotes in
T2412 8988-8997 NN denotes morbidity
T2411 8980-8987 VB denotes reduced
T2410 8976-8979 CC denotes and
T2409 8967-8975 NN denotes survival
T2408 8958-8966 VB denotes enhanced
T2407 8953-8957 VB denotes show
T2406 8948-8952 NN denotes mice
T2405 8937-8947 NN denotes A20myel-KO
T2404 8935-8936 -COMMA- denotes ,
T2403 8922-8935 RB denotes Interestingly
T2402 8909-8920 NN denotes macrophages
T2401 8906-8908 IN denotes in
T2400 8896-8905 NN denotes signaling
T2399 8886-8895 JJ denotes antiviral
T2398 8882-8885 CC denotes and
T2397 8866-8881 JJ denotes proinflammatory
T2396 8854-8865 JJ denotes IAV-induced
T2395 8851-8853 IN denotes of
T2394 8841-8850 NN denotes regulator
T2393 8832-8840 JJ denotes negative
T2340 8544-8551 RB denotes However
T2339 8541-8542 -RRB- denotes ]
T2338 8539-8541 CD denotes 52
T2337 8538-8539 -LRB- denotes [
T2336 8537-8538 CD denotes –
T2335 8536-8537 -RRB- denotes ]
T2334 8534-8536 CD denotes 49
T2333 8533-8534 -LRB- denotes [
T2332 8527-8532 NN denotes IRF-3
T2331 8523-8526 CC denotes and
T2330 8517-8522 NN denotes NF-κB
T2329 8514-8516 TO denotes to
T2328 8504-8513 NN denotes signaling
T2327 8491-8503 JJ denotes TLR3-induced
T2326 8487-8490 CC denotes and
T2325 8480-8486 NN denotes RIG-I-
T2324 8471-8479 VB denotes regulate
T2323 8467-8470 MD denotes may
T2322 8463-8466 NN denotes A20
T2321 8458-8462 IN denotes that
T2320 8447-8457 VB denotes indicating
T2319 8445-8446 -COMMA- denotes ,
T2318 8440-8445 NN denotes lines
T2317 8435-8439 NN denotes cell
T2316 8426-8434 JJ denotes specific
T2315 8423-8425 IN denotes in
T2314 8413-8422 NN denotes silencing
T2313 8410-8412 CC denotes or
T2312 8395-8409 NN denotes overexpression
T2311 8389-8394 VB denotes using
T2310 8381-8388 NN denotes studies
T2309 8375-8380 FW denotes vitro
T2308 8372-8374 FW denotes in
T2307 8369-8371 IN denotes of
T2306 8362-8368 NN denotes number
T2305 8360-8361 DT denotes a
T2304 8357-8359 TO denotes to
T2303 8349-8356 VB denotes limited
T2302 8345-8348 CC denotes and
T2301 8335-8344 VB denotes described
T2300 8330-8334 RB denotes well
T2299 8325-8329 RB denotes less
T2298 8322-8324 VB denotes is
T2297 8312-8321 NN denotes responses
T2296 8305-8311 JJ denotes immune
T2295 8295-8304 JJ denotes antiviral
T2294 8292-8294 IN denotes of
T2293 8281-8291 NN denotes regulation
T2292 8277-8280 DT denotes the
T2291 8274-8276 IN denotes in
T2290 8270-8273 NN denotes A20
T2289 8267-8269 IN denotes of
T2288 8262-8266 NN denotes role
T2287 8258-8261 DT denotes the
T2286 8256-8257 -COMMA- denotes ,
T2285 8247-8256 NN denotes responses
T2284 8231-8246 JJ denotes proinflammatory
T2283 8228-8230 IN denotes of
T2282 8217-8227 NN denotes regulation
T2281 8213-8216 DT denotes the
T2280 8210-8212 IN denotes in
T2279 8201-8209 NN denotes function
T2278 8189-8200 VB denotes established
T2277 8184-8188 RB denotes well
T2276 8180-8183 PRP-DOLLAR- denotes its
T2275 8177-8179 TO denotes to
T2274 8168-8176 NN denotes contrast
T2273 8165-8167 IN denotes In
T2272 8162-8163 -RRB- denotes ]
T2271 8160-8162 CD denotes 45
T2270 8159-8160 -LRB- denotes [
T2269 8146-8158 NN denotes inflammation
T2268 8138-8145 JJ denotes chronic
T2267 8134-8137 CC denotes and
T2266 8125-8133 NN denotes diseases
T2265 8114-8124 JJ denotes autoimmune
T2264 8106-8113 JJ denotes several
T2263 8101-8105 IN denotes with
T2262 8090-8100 VB denotes associated
T2261 8086-8089 VB denotes are
T2260 8081-8085 WDT denotes that
T2259 8075-8080 NN denotes locus
T2258 8071-8074 NN denotes A20
T2257 8067-8070 DT denotes the
T2256 8064-8066 IN denotes in
T2255 8050-8063 NN denotes polymorphisms
T2254 8047-8049 IN denotes of
T2253 8032-8046 NN denotes identification
T2252 8028-8031 DT denotes the
T2251 8020-8027 IN denotes through
T2250 8008-8019 VB denotes illustrated
T2249 8003-8007 VB denotes been
T2248 7994-8002 RB denotes recently
T2247 7990-7993 VB denotes has
T2246 7982-7989 NN denotes disease
T2245 7976-7981 JJ denotes human
T2244 7972-7975 IN denotes for
T2243 7963-7971 NN denotes findings
T2242 7957-7962 DT denotes these
T2241 7954-7956 IN denotes of
T2240 7944-7953 NN denotes relevance
T2239 7940-7943 DT denotes The
T2238 7930-7938 NN denotes response
T2237 7917-7929 JJ denotes inflammatory
T2236 7913-7916 DT denotes the
T2235 7910-7912 IN denotes on
T2234 7904-7909 NN denotes brake
T2233 7894-7903 JJ denotes important
T2232 7891-7893 DT denotes an
T2231 7888-7890 VB denotes is
T2230 7884-7887 NN denotes A20
T2229 7879-7883 IN denotes that
T2228 7866-7878 VB denotes illustrating
T2227 7858-7865 RB denotes further
T2226 7856-7857 -COMMA- denotes ,
T2225 7855-7856 -RRB- denotes ]
T2224 7853-7855 CD denotes 48
T2223 7852-7853 -LRB- denotes [
T2222 7851-7852 CD denotes –
T2221 7850-7851 -RRB- denotes ]
T2220 7848-7850 CD denotes 42
T2219 7847-7848 -LRB- denotes [
T2218 7834-7846 NN denotes inflammation
T2217 7826-7833 JJ denotes chronic
T2216 7822-7825 CC denotes and
T2215 7809-7821 NN denotes autoimmunity
T2214 7804-7808 IN denotes with
T2213 7793-7803 VB denotes associated
T2212 7790-7792 VB denotes be
T2211 7787-7789 TO denotes to
T2210 7781-7786 VB denotes shown
T2209 7777-7780 VB denotes was
T2208 7771-7776 NN denotes types
T2207 7766-7770 NN denotes cell
T2206 7757-7765 JJ denotes specific
T2205 7754-7756 IN denotes in
T2204 7750-7753 NN denotes A20
T2203 7747-7749 IN denotes of
T2202 7737-7746 NN denotes targeting
T2201 7732-7736 NN denotes gene
T2200 7730-7731 -COMMA- denotes ,
T2199 7722-7730 RB denotes recently
T2198 7717-7721 RB denotes More
T2197 7714-7715 -RRB- denotes ]
T2196 7712-7714 CD denotes 37
T2195 7711-7712 -LRB- denotes [
T2194 7702-7710 NN denotes cachexia
T2193 7698-7701 CC denotes and
T2192 7685-7697 NN denotes inflammation
T2191 7673-7684 JJ denotes multi-organ
T2190 7666-7672 JJ denotes severe
T2189 7663-7665 TO denotes to
T2188 7659-7662 JJ denotes due
T2187 7653-7658 NN denotes birth
T2186 7647-7652 IN denotes after
T2185 7641-7646 RB denotes early
T2184 7637-7640 VB denotes die
T2183 7632-7636 NN denotes mice
T2182 7622-7631 JJ denotes deficient
T2181 7618-7621 NN denotes A20
T2180 7613-7617 IN denotes that
T2179 7608-7612 NN denotes fact
T2178 7604-7607 DT denotes the
T2177 7601-7603 IN denotes by
T2176 7588-7600 VB denotes demonstrated
T2175 7580-7587 RB denotes clearly
T2174 7577-7579 VB denotes is
T2173 7573-7576 NN denotes A20
T2172 7570-7572 IN denotes of
T2171 7565-7569 NN denotes role
T2170 7547-7564 JJ denotes anti-inflammatory
T2169 7543-7546 DT denotes The
T2168 7540-7541 -RRB- denotes ]
T2167 7538-7540 CD denotes 41
T2166 7537-7538 -LRB- denotes [
T2165 7531-7536 NN denotes IL-1R
T2164 7527-7530 CC denotes and
T2163 7525-7526 -COMMA- denotes ,
T2162 7524-7525 -RRB- denotes ]
T2161 7522-7524 CD denotes 40
T2160 7521-7522 -LRB- denotes [
T2159 7516-7520 NN denotes TLR4
T2158 7514-7515 -COMMA- denotes ,
T2157 7513-7514 -RRB- denotes ]
T2156 7511-7513 CD denotes 39
T2155 7510-7511 -LRB- denotes [
T2154 7509-7510 CD denotes –
T2153 7508-7509 -RRB- denotes ]
T2152 7506-7508 CD denotes 37
T2151 7505-7506 -LRB- denotes [
T1730 5095-5097 TO denotes to
T1729 5084-5094 VB denotes contribute
T1728 5074-5083 NN denotes receptors
T1727 5069-5073 DT denotes Both
T1726 5066-5067 -RRB- denotes ]
T1725 5064-5066 CD denotes 12
T1724 5063-5064 -LRB- denotes [
T1723 5062-5063 CD denotes –
T1722 5061-5062 -RRB- denotes ]
T1721 5059-5061 CD denotes 10
T1720 5058-5059 -LRB- denotes [
T1719 5048-5057 NN denotes infection
T1718 5044-5047 NN denotes IAV
T1717 5041-5043 IN denotes of
T1716 5033-5040 NN denotes sensors
T1715 5030-5032 IN denotes as
T1714 5019-5029 VB denotes implicated
T1713 5014-5018 VB denotes been
T1712 5009-5013 VB denotes have
T1711 5003-5008 NN denotes RIG-I
T1710 4999-5002 CC denotes and
T1709 4994-4998 NN denotes TLR3
T1708 4981-4992 NN denotes replication
T1707 4975-4980 JJ denotes viral
T1706 4972-4974 IN denotes of
T1705 4959-4971 NN denotes intermediate
T1537 3987-3988 CD denotes 4
T1536 3986-3987 -LRB- denotes [
T1535 3982-3985 NNP denotes DAI
T1534 3980-3981 -COMMA- denotes ,
T1533 3976-3980 NN denotes TLR9
T1532 3968-3975 VB denotes include
T1531 3960-3967 NN denotes viruses
T1530 3956-3959 NN denotes DNA
T1529 3953-3955 TO denotes to
T1528 3943-3952 NN denotes responses
T1527 3936-3942 JJ denotes immune
T1526 3926-3935 JJ denotes antiviral
T1525 3918-3925 VB denotes mediate
T1524 3913-3917 WDT denotes that
T1523 3905-3912 NN denotes sensors
T1522 3901-3904 NN denotes DNA
T1521 3887-3900 JJ denotes Intracellular
T1520 3884-3885 -RRB- denotes )
T1519 3880-3884 NN denotes MDA5
T1518 3878-3879 -COMMA- denotes ,
T1517 3873-3878 NN denotes RIG-I
T1516 3871-3872 -COMMA- denotes ,
T1515 3867-3871 NN denotes TLR3
T1514 3866-3867 -LRB- denotes (
T1513 3862-3865 NN denotes RNA
T1512 3853-3861 JJ denotes stranded
T1511 3846-3852 JJ denotes double
T1510 3843-3845 CC denotes or
T1509 3841-3842 -RRB- denotes )
T1508 3837-3841 NN denotes Nod2
T1507 3835-3836 -COMMA- denotes ,
T1506 3831-3835 NN denotes TLR8
T1505 3829-3830 -COMMA- denotes ,
T1504 3825-3829 NN denotes TLR7
T1503 3824-3825 -LRB- denotes (
T1502 3815-3823 JJ denotes stranded
T1501 3808-3814 JJ denotes single
T1500 3802-3807 JJ denotes viral
T1499 3799-3801 IN denotes of
T1498 3790-3798 NN denotes presence
T1497 3786-3789 DT denotes the
T1496 3779-3785 VB denotes detect
T1495 3777-3778 -RRB- denotes )
T1494 3773-3777 NN denotes NLRs
T1493 3772-3773 -LRB- denotes (
T1492 3762-3771 NN denotes receptors
T1491 3753-3761 JJ denotes Nod-like
T1490 3750-3752 CC denotes or
T1489 3748-3749 -RRB- denotes )
T1488 3744-3748 NN denotes RLRs
T1487 3743-3744 -LRB- denotes (
T1486 3733-3742 NN denotes receptors
T1485 3722-3732 JJ denotes RIG-I-like
T1484 3713-3721 NN denotes helicase
T1483 3709-3712 NN denotes RNA
T1482 3697-3708 JJ denotes cytoplasmic
T1481 3693-3696 CC denotes and
T1480 3691-3692 -RRB- denotes )
T1479 3687-3691 NN denotes TLRs
T1478 3686-3687 -LRB- denotes (
T1477 3676-3685 NN denotes receptors
T1476 3666-3675 JJ denotes Toll-like
T1475 3656-3665 JJ denotes Endosomal
T1474 3653-3654 -RRB- denotes ]
T1473 3652-3653 CD denotes 3
T1472 3651-3652 -LRB- denotes [
T1471 3646-3650 NN denotes PRRs
T1470 3632-3645 JJ denotes intracellular
T1469 3623-3631 JJ denotes specific
T1468 3620-3622 IN denotes by
T1467 3613-3619 VB denotes sensed
T1466 3610-3612 VB denotes be
T1465 3606-3609 MD denotes can
T1464 3604-3605 -COMMA- denotes ,
T1463 3596-3604 NN denotes products
T1462 3582-3595 NN denotes transcription
T1461 3576-3581 JJ denotes viral
T1460 3572-3575 CC denotes and
T1459 3558-3571 NN denotes intermediates
T1458 3546-3557 NN denotes replication
T1457 3540-3545 JJ denotes viral
T1456 3538-3539 -COMMA- denotes ,
T1455 3535-3538 NN denotes DNA
T1454 3531-3534 CC denotes and
T1453 3527-3530 NN denotes RNA
T1452 3521-3526 JJ denotes viral
T1451 3518-3520 IN denotes as
T1450 3513-3517 JJ denotes such
T1449 3511-3512 -COMMA- denotes ,
T1448 3506-3511 NN denotes acids
T1447 3498-3505 JJ denotes nucleic
T1446 3492-3497 JJ denotes viral
T1445 3489-3491 IN denotes of
T1444 3480-3488 NN denotes presence
T1443 3476-3479 DT denotes The
T1442 3473-3474 -RRB- denotes ]
T1441 3472-3473 CD denotes 2
T1440 3471-3472 -LRB- denotes [
T1439 3469-3470 -COMMA- denotes ,
T1438 3468-3469 -RRB- denotes ]
T1437 3467-3468 CD denotes 1
T1436 3466-3467 -LRB- denotes [
T1435 3461-3465 NN denotes IRF7
T1434 3457-3460 CC denotes and
T1433 3452-3456 NN denotes IRF3
T1432 3450-3451 -COMMA- denotes ,
T1431 3446-3450 NN denotes AP-1
T1430 3444-3445 -COMMA- denotes ,
T1429 3439-3444 NN denotes NF-κB
T1428 3436-3438 IN denotes as
T1427 3431-3435 JJ denotes such
T1426 3423-3430 NN denotes factors
T1425 3409-3422 NN denotes transcription
T1424 3401-3408 JJ denotes various
T1423 3393-3400 VB denotes control
T1422 3388-3392 WDT denotes that
T1421 3379-3387 NN denotes pathways
T1420 3369-3378 NN denotes signaling
T1419 3358-3368 JJ denotes downstream
T1418 3355-3357 IN denotes of
T1417 3344-3354 NN denotes activation
T1416 3336-3343 IN denotes through
T1415 3334-3335 -RRB- denotes )
T1414 3329-3334 NN denotes IFN-β
T1413 3325-3328 CC denotes and
T1412 3323-3324 -RRB- denotes )
T1411 3318-3323 NN denotes IFN-α
T1410 3317-3318 -LRB- denotes (
T1409 3304-3316 NN denotes interferon-α
T1408 3303-3304 -LRB- denotes (
T1407 3291-3302 NN denotes interferons
T1406 3289-3290 CD denotes I
T1405 3284-3288 NN denotes type
T1404 3280-3283 CC denotes and
T1403 3278-3279 -RRB- denotes )
T1402 3274-3278 NN denotes IL-1
T1401 3270-3273 CC denotes and
T1400 3265-3269 NN denotes IL-6
T1399 3263-3264 -COMMA- denotes ,
T1398 3260-3263 NN denotes TNF
T1397 3255-3259 FW denotes e.g.
T1396 3254-3255 -LRB- denotes (
T1395 3244-3253 NN denotes cytokines
T1394 3228-3243 JJ denotes proinflammatory
T1393 3223-3227 NN denotes host
T1392 3220-3222 IN denotes of
T1391 3209-3219 NN denotes production
T1390 3205-3208 DT denotes the
T1389 3197-3204 VB denotes induces
T1388 3192-3196 NN denotes PRRs
T1387 3189-3191 IN denotes of
T1386 3178-3188 NN denotes Triggering
T1385 3168-3176 NN denotes pathogen
T1384 3159-3167 VB denotes invading
T1383 3155-3158 DT denotes the
T1382 3152-3154 IN denotes of
T1381 3141-3151 NN denotes structures
T1380 3131-3140 JJ denotes molecular
T1379 3121-3130 VB denotes conserved
T1378 3114-3120 VB denotes detect
T1377 3108-3113 WDT denotes which
T1376 3106-3107 -COMMA- denotes ,
T1375 3105-3106 -RRB- denotes )
T1374 3102-3105 NN denotes PRR
T1373 3101-3102 -LRB- denotes (
T1372 3091-3100 NN denotes receptors
T1371 3079-3090 NN denotes recognition
T1370 3071-3078 NN denotes pattern
T1369 3059-3070 VB denotes specialized
T1368 3056-3058 IN denotes of
T1367 3049-3055 NN denotes action
T1366 3045-3048 DT denotes the
T1365 3036-3044 VB denotes involves
T1364 3027-3035 NN denotes response
T1363 3020-3026 JJ denotes immune
T1362 3010-3019 JJ denotes antiviral
T1361 3003-3009 JJ denotes innate
T1360 2992-3002 JJ denotes protective
T1359 2990-2991 DT denotes a
T1358 2987-2989 IN denotes of
T1357 2976-2986 NN denotes initiation
T1356 2972-2975 DT denotes The
T1355 2959-2970 NN denotes replication
T1354 2953-2958 PRP-DOLLAR- denotes their
T1353 2949-2952 IN denotes for
T1352 2944-2948 NN denotes cell
T1351 2939-2943 NN denotes host
T1350 2935-2938 DT denotes the
T1349 2932-2934 IN denotes on
T1348 2925-2931 VB denotes depend
T2392 8824-8831 JJ denotes crucial
T2391 8822-8823 DT denotes a
T2390 8819-8821 VB denotes is
T2389 8815-8818 NN denotes A20
T2388 8810-8814 IN denotes that
T2387 8801-8809 NN denotes evidence
T2386 8793-8800 VB denotes provide
T2385 8788-8792 RB denotes here
T2384 8785-8787 PRP denotes we
T2383 8783-8784 -COMMA- denotes ,
T2382 8779-8783 NN denotes mice
T2381 8773-8778 DT denotes these
T2380 8770-8772 IN denotes of
T2379 8762-8769 VB denotes derived
T2378 8756-8761 NN denotes cells
T2377 8748-8755 JJ denotes primary
T2376 8744-8747 CC denotes and
T2375 8740-8743 NN denotes lab
T2374 8736-8739 PRP-DOLLAR- denotes our
T2373 8733-8735 IN denotes in
T2372 8723-8732 VB denotes generated
T2371 8714-8722 RB denotes recently
T2370 8709-8713 VB denotes were
T2369 8704-8708 WDT denotes that
T2368 8702-8703 -RRB- denotes )
T2367 8692-8702 NN denotes A20myel-KO
T2366 8691-8692 -LRB- denotes (
T2365 8686-8690 NN denotes mice
T2364 8677-8685 NN denotes knockout
T2363 8673-8676 NN denotes A20
T2362 8664-8672 JJ denotes specific
T2361 8659-8663 NN denotes cell
T2360 8651-8658 JJ denotes myeloid
T2359 8645-8650 VB denotes Using
T2358 8634-8643 VB denotes clarified
T2357 8631-8633 VB denotes be
T2356 8628-8630 TO denotes to
T2355 8620-8627 VB denotes remains
T2354 8610-8619 NN denotes infection
T2353 8604-8609 JJ denotes viral
T2352 8601-8603 TO denotes to
T2351 8592-8600 NN denotes response
T2350 8588-8591 DT denotes the
T2349 8585-8587 IN denotes in
T2348 8581-8584 NN denotes A20
T2347 8578-8580 IN denotes of
T2346 8573-8577 NN denotes role
T2345 8568-8572 FW denotes vivo
T2344 8565-8567 FW denotes in
T2343 8557-8564 JJ denotes precise
T2342 8553-8556 DT denotes the
T2341 8551-8552 -COMMA- denotes ,
T1934 6241-6242 -RRB- denotes ]
T1933 6239-6241 CD denotes 24
T1932 6238-6239 -LRB- denotes [
T1931 6236-6237 -COMMA- denotes ,
T1930 6235-6236 -RRB- denotes ]
T1929 6233-6235 CD denotes 23
T1928 6232-6233 -LRB- denotes [
T1927 6225-6231 NNP denotes Riplet
T1926 6221-6224 CC denotes and
T1925 6219-6220 -RRB- denotes ]
T1924 6217-6219 CD denotes 22
T1923 6216-6217 -LRB- denotes [
T1922 6209-6215 NN denotes TRIM25
T1921 6206-6208 IN denotes as
T1347 2919-2924 WDT denotes which
T1346 2909-2918 NN denotes pathogens
T1345 2901-2908 JJ denotes diverse
T1344 2894-2900 RB denotes highly
T1343 2891-2893 IN denotes of
T1342 2885-2890 NN denotes class
T1341 2883-2884 DT denotes a
T1340 2879-2882 VB denotes are
T1339 2871-2878 NN denotes Viruses
T1704 4956-4958 DT denotes an
T1703 4950-4955 VB denotes being
T1702 4943-4949 JJ denotes latter
T1701 4939-4942 DT denotes the
T1700 4937-4938 -COMMA- denotes ,
T1699 4934-4937 NN denotes RNA
T1698 4925-4933 JJ denotes stranded
T1697 4918-4924 JJ denotes double
T1696 4914-4917 CC denotes and
T1695 4910-4913 NN denotes RNA
T1694 4902-4909 JJ denotes genomic
T1693 4886-4901 JJ denotes single-stranded
T1692 4883-4885 IN denotes of
T1691 4878-4882 NN denotes cell
T1690 4873-4877 NN denotes host
T1689 4869-4872 DT denotes the
T1688 4866-4868 IN denotes in
T1687 4857-4865 NN denotes exposure
T1686 4853-4856 DT denotes the
T1685 4850-4852 TO denotes to
T1684 4844-4849 VB denotes leads
T1683 4834-4843 NN denotes infection
T1682 4830-4833 NN denotes IAV
T1681 4820-4828 JJ denotes critical
T1680 4817-4819 VB denotes is
T1679 4807-4816 NN denotes responses
T1678 4800-4806 JJ denotes immune
T1677 4788-4799 JJ denotes IAV-induced
T1676 4779-4787 VB denotes regulate
T1675 4774-4778 WDT denotes that
T1674 4763-4773 NN denotes mechanisms
T1673 4759-4762 DT denotes the
T1672 4756-4758 IN denotes of
T1671 4742-4755 NN denotes understanding
T1670 4740-4741 -COMMA- denotes ,
T1669 4733-4740 NN denotes context
T1668 4728-4732 DT denotes this
T1667 4725-4727 IN denotes In
T1666 4713-4723 NN denotes strategies
T1665 4703-4712 JJ denotes antiviral
T1664 4697-4702 JJ denotes novel
T1663 4686-4696 VB denotes developing
T1662 4683-4685 IN denotes of
T1661 4672-4682 NN denotes importance
T1660 4668-4671 DT denotes the
T1659 4656-4667 VB denotes underscores
T1658 4646-4655 NN denotes potential
T1657 4637-4645 JJ denotes pandemic
T1656 4632-4636 IN denotes with
T1655 4624-4631 NN denotes viruses
T1654 4614-4623 NN denotes influenza
T1653 4611-4613 IN denotes of
T1652 4603-4610 NN denotes strains
T1651 4588-4602 JJ denotes drug-resistant
T1650 4585-4587 IN denotes of
T1649 4575-4584 NN denotes Emergence
T1648 4565-4573 NN denotes response
T1647 4552-4564 JJ denotes inflammatory
T1646 4547-4551 NN denotes host
T1645 4537-4546 JJ denotes excessive
T1644 4534-4536 DT denotes an
T1643 4531-4533 TO denotes to
T1642 4527-4530 IN denotes due
T1641 4524-4526 VB denotes be
T1640 4521-4523 TO denotes to
T1639 4512-4520 VB denotes believed
T1638 4502-4511 RB denotes generally
T1637 4499-4501 VB denotes is
T1636 4493-4498 WDT denotes which
T1635 4491-4492 -COMMA- denotes ,
T1634 4482-4491 NN denotes mortality
T1633 4469-4481 JJ denotes considerable
T1632 4462-4468 VB denotes causes
T1631 4457-4461 WDT denotes that
T1630 4449-4456 NN denotes disease
T1629 4437-4448 JJ denotes respiratory
T1628 4431-4436 JJ denotes acute
T1627 4420-4430 JJ denotes contagious
T1626 4418-4419 DT denotes a
T1625 4415-4417 IN denotes of
T1624 4409-4414 NN denotes agent
T1623 4397-4408 JJ denotes etiological
T1622 4393-4396 DT denotes the
T1621 4390-4392 VB denotes is
T1620 4388-4389 -RRB- denotes )
T1619 4385-4388 NN denotes IAV
T1618 4384-4385 -LRB- denotes (
T1617 4378-4383 NN denotes virus
T1616 4376-4377 NN denotes A
T1615 4366-4375 NN denotes Influenza
T1614 4363-4364 -RRB- denotes ]
T1613 4362-4363 CD denotes 9
T1612 4361-4362 -LRB- denotes [
T1611 4352-4360 NN denotes proteins
T1610 4342-4351 JJ denotes antiviral
T1609 4339-4341 IN denotes of
T1608 4328-4338 NN denotes production
T1607 4324-4327 DT denotes the
T1606 4320-4323 IN denotes for
T1605 4312-4319 NN denotes sensors
T1604 4308-4311 NN denotes DNA
T1603 4304-4307 CC denotes and
T1602 4300-4303 NN denotes RNA
T1601 4290-4299 JJ denotes cytosolic
T1600 4286-4289 DT denotes the
T1599 4283-4285 IN denotes on
T1598 4276-4282 VB denotes depend
T1597 4274-4275 -COMMA- denotes ,
T1596 4263-4274 NN denotes fibroblasts
T1595 4259-4262 CC denotes and
T1594 4247-4258 NN denotes macrophages
T1593 4245-4246 -COMMA- denotes ,
T1592 4244-4245 -RRB- denotes )
T1591 4241-4244 NN denotes cDC
T1590 4240-4241 -LRB- denotes (
T1589 4237-4239 NN denotes DC
T1588 4224-4236 JJ denotes conventional
T1587 4214-4223 VB denotes including
T1586 4212-4213 -COMMA- denotes ,
T1585 4207-4212 NN denotes types
T1584 4202-4206 NN denotes cell
T1583 4196-4201 JJ denotes other
T1582 4191-4195 JJ denotes most
T1581 4185-4190 IN denotes while
T1580 4183-4184 -COMMA- denotes ,
T1579 4182-4183 -RRB- denotes )
T1578 4179-4182 NN denotes pDC
T1577 4178-4179 -LRB- denotes (
T1576 4172-4177 NN denotes cells
T1575 4162-4171 JJ denotes dendritic
T1574 4149-4161 JJ denotes plasmacytoid
T1573 4139-4148 VB denotes producing
T1572 4135-4138 NN denotes IFN
T1571 4133-4134 CD denotes I
T1570 4128-4132 NN denotes type
T1569 4116-4127 VB denotes specialized
T1568 4113-4115 TO denotes to
T1567 4102-4112 JJ denotes restricted
T1566 4098-4101 VB denotes are
T1565 4088-4097 NN denotes responses
T1564 4078-4087 JJ denotes antiviral
T1563 4069-4077 VB denotes mediated
T1562 4065-4068 NN denotes TLR
T1561 4062-4063 -RRB- denotes ]
T1560 4061-4062 CD denotes 8
T1559 4060-4061 -LRB- denotes [
T1558 4054-4059 NN denotes IFI16
T1557 4050-4053 CC denotes and
T1556 4048-4049 -RRB- denotes ]
T1555 4047-4048 CD denotes 7
T1554 4046-4047 -LRB- denotes [
T1553 4044-4045 -COMMA- denotes ,
T1552 4043-4044 -RRB- denotes ]
T1551 4042-4043 CD denotes 6
T1550 4041-4042 -LRB- denotes [
T1549 4039-4040 -COMMA- denotes ,
T1548 4038-4039 -RRB- denotes ]
T1547 4037-4038 CD denotes 5
T1546 4036-4037 -LRB- denotes [
T1545 4031-4035 NN denotes AIM2
T1544 4022-4030 NN denotes proteins
T1543 4011-4021 VB denotes containing
T1542 4004-4010 NN denotes domain
T1541 3998-4003 NN denotes PYHIN
T1540 3994-3997 DT denotes the
T1539 3990-3993 CC denotes and
T1538 3988-3989 -RRB- denotes ]
T181 818-821 DT denotes the
T180 815-817 IN denotes in
T179 811-814 NN denotes A20
T178 803-810 NN denotes protein
T177 785-802 JJ denotes ubiquitin-editing
T176 781-784 DT denotes the
T175 778-780 IN denotes of
T174 773-777 NN denotes role
T173 769-772 DT denotes the
T172 761-768 VB denotes examine
T171 758-760 TO denotes to
T170 753-757 NN denotes mice
T169 744-752 NN denotes knockout
T168 740-743 NN denotes A20
T167 731-739 JJ denotes specific
T166 726-730 NN denotes cell
T165 718-725 JJ denotes myeloid
T164 713-717 VB denotes used
T163 710-712 PRP denotes we
T162 705-709 RB denotes Here
T161 693-703 NN denotes strategies
T160 681-692 JJ denotes therapeutic
T159 675-680 JJ denotes novel
T158 667-674 VB denotes develop
T157 664-666 TO denotes to
T156 653-663 NN denotes importance
T155 649-652 JJ denotes key
T154 646-648 IN denotes of
T153 643-645 VB denotes is
T152 635-642 NN denotes viruses
T151 629-634 JJ denotes other
T150 625-628 CC denotes and
T149 621-624 NN denotes IAV
T148 618-620 TO denotes to
T147 608-617 NN denotes responses
T146 601-607 JJ denotes immune
T145 594-600 JJ denotes innate
T144 585-593 VB denotes regulate
T143 580-584 WDT denotes that
T142 569-579 NN denotes mechanisms
T141 565-568 DT denotes the
T140 551-564 VB denotes Understanding
T139 539-549 NN denotes interferon
T138 529-538 JJ denotes antiviral
T137 525-528 CC denotes and
T136 515-524 NN denotes cytokines
T135 499-514 JJ denotes proinflammatory
T134 496-498 IN denotes of
T133 485-495 NN denotes production
T132 481-484 DT denotes the
T131 473-480 VB denotes induces
T130 469-472 CC denotes and
T129 463-468 NN denotes RIG-I
T128 454-462 NN denotes receptor
T127 442-453 NN denotes recognition
T126 433-441 NN denotes pathogen
T125 419-432 JJ denotes intracellular
T124 415-418 DT denotes the
T123 405-414 VB denotes activates
T122 399-404 WDT denotes which
T121 397-398 -COMMA- denotes ,
T120 392-397 NN denotes cycle
T119 387-391 NN denotes life
T118 375-386 NN denotes replication
T117 371-374 DT denotes the
T116 364-370 IN denotes during
T115 351-363 NN denotes intermediate
T114 348-350 DT denotes an
T113 345-347 IN denotes as
T112 341-344 NN denotes RNA
T111 325-340 JJ denotes double-stranded
T110 316-324 VB denotes produces
T109 314-315 -RRB- denotes )
T108 311-314 NN denotes IAV
T107 310-311 -LRB- denotes (
T106 304-309 NN denotes virus
T105 302-303 NN denotes A
T104 292-301 NN denotes Influenza
T103 281-290 NN denotes molecules
T102 271-280 JJ denotes microbial
T101 262-270 JJ denotes specific
T100 259-261 TO denotes to
T99 248-258 VB denotes responding
T98 245-247 IN denotes by
T97 235-244 NN denotes pathogens
T96 229-234 JJ denotes other
T95 225-228 CC denotes and
T94 217-224 NN denotes viruses
T93 209-216 IN denotes against
T92 201-208 NN denotes defense
T91 198-200 IN denotes of
T90 193-197 NN denotes line
T89 187-192 JJ denotes first
T88 183-186 DT denotes the
T87 174-182 VB denotes provides
T86 165-173 NN denotes response
T85 158-164 JJ denotes immune
T84 151-157 JJ denotes innate
T83 147-150 DT denotes The
T221 1092-1096 NN denotes type
T220 1088-1091 CC denotes and
T219 1077-1087 NN denotes chemokines
T218 1075-1076 -COMMA- denotes ,
T217 1066-1075 NN denotes cytokines
T216 1050-1065 JJ denotes proinflammatory
T215 1047-1049 IN denotes of
T214 1036-1046 NN denotes production
T213 1026-1035 VB denotes increased
T212 1021-1025 IN denotes with
T211 1009-1020 JJ denotes concomitant
T210 1007-1008 -COMMA- denotes ,
T209 997-1007 NN denotes activation
T208 992-996 NN denotes IRF3
T207 988-991 CC denotes and
T206 982-987 NN denotes NF-κB
T205 973-981 VB denotes enhanced
T204 970-972 IN denotes by
T203 958-969 VB denotes illustrated
T202 955-957 IN denotes as
T201 953-954 -COMMA- denotes ,
T200 944-953 NN denotes infection
T199 940-943 NN denotes IAV
T198 936-939 CC denotes and
T197 932-935 NN denotes RNA
T196 923-931 JJ denotes stranded
T195 916-922 VB denotes double
T194 913-915 TO denotes to
T193 897-912 JJ denotes hyperresponsive
T192 892-896 VB denotes were
T191 880-891 NN denotes macrophages
T190 870-879 JJ denotes deficient
T189 866-869 NN denotes A20
T188 855-864 NN denotes infection
T187 851-854 NN denotes IAV
T186 848-850 TO denotes to
T185 842-847 NN denotes cells
T184 834-841 JJ denotes myeloid
T183 831-833 IN denotes of
T182 822-830 NN denotes response
T295 1576-1586 NN denotes infections
T294 1572-1575 NN denotes IAV
T293 1569-1571 IN denotes of
T292 1558-1568 NN denotes management
T291 1554-1557 DT denotes the
T290 1551-1553 IN denotes in
T289 1542-1550 NN denotes interest
T288 1539-1541 IN denotes of
T287 1536-1538 VB denotes be
T286 1530-1535 MD denotes might
T285 1526-1529 NN denotes A20
T284 1523-1525 IN denotes of
T283 1512-1522 NN denotes inhibition
T282 1501-1511 NN denotes conditions
T281 1493-1500 JJ denotes certain
T280 1487-1492 IN denotes under
T279 1482-1486 IN denotes that
T278 1474-1481 VB denotes suggest
T277 1470-1473 CC denotes and
T276 1468-1469 -COMMA- denotes ,
T275 1459-1468 NN denotes lethality
T274 1447-1458 JJ denotes IAV-induced
T273 1442-1446 IN denotes with
T272 1431-1441 VB denotes associated
T271 1428-1430 VB denotes is
T270 1419-1427 NN denotes response
T269 1403-1418 JJ denotes proinflammatory
T268 1398-1402 NN denotes host
T267 1388-1397 JJ denotes excessive
T266 1385-1387 DT denotes an
T265 1380-1384 IN denotes that
T264 1373-1379 NN denotes belief
T263 1365-1372 JJ denotes general
T262 1361-1364 DT denotes the
T261 1351-1360 VB denotes challenge
T260 1343-1350 NN denotes results
T259 1337-1342 DT denotes These
T258 1326-1335 NN denotes infection
T257 1322-1325 NN denotes IAV
T256 1315-1321 JJ denotes lethal
T255 1307-1314 IN denotes against
T254 1297-1306 VB denotes protected
T253 1293-1296 VB denotes are
T252 1288-1292 NN denotes mice
T251 1279-1287 NN denotes knockout
T250 1275-1278 NN denotes A20
T249 1266-1274 JJ denotes specific
T248 1261-1265 NN denotes cell
T247 1253-1260 JJ denotes myeloid
T246 1251-1252 -COMMA- denotes ,
T245 1239-1251 RB denotes Surprisingly
T244 1233-1237 NN denotes mice
T243 1224-1232 JJ denotes infected
T242 1220-1223 NN denotes IAV
T241 1217-1219 IN denotes of
T240 1211-1216 NN denotes lungs
T239 1207-1210 DT denotes the
T238 1204-1206 IN denotes in
T237 1192-1203 NN denotes neutrophils
T236 1188-1191 CC denotes and
T235 1176-1187 NN denotes macrophages
T234 1167-1175 JJ denotes alveolar
T233 1164-1166 IN denotes of
T232 1157-1163 NN denotes number
T231 1147-1156 VB denotes increased
T230 1144-1146 DT denotes an
T229 1139-1143 IN denotes with
T228 1128-1138 VB denotes associated
T227 1124-1127 VB denotes was
T226 1119-1123 DT denotes this
T225 1114-1118 FW denotes vivo
T224 1111-1113 FW denotes In
T223 1099-1109 NN denotes interferon
T222 1097-1098 CD denotes I
T12034 25631-25634 DT denotes the
T12033 25627-25630 CC denotes and
T12032 25616-25626 NN denotes parenchyma
T12031 25611-25615 NN denotes lung
T12030 25606-25610 CC denotes both
T12029 25597-25605 VB denotes populate
T12028 25585-25596 NN denotes macrophages
T12027 25583-25584 -COMMA- denotes ,
T12026 25572-25583 NN denotes environment
T12025 25562-25571 JJ denotes pulmonary
T12024 25558-25561 DT denotes the
T12023 25555-25557 IN denotes In
T12022 25544-25553 NN denotes infection
T12021 25539-25543 NN denotes lung
T12020 25535-25538 NN denotes IAV
T12019 25532-25534 TO denotes to
T12018 25523-25531 NN denotes response
T12017 25516-25522 JJ denotes immune
T12016 25509-25515 JJ denotes innate
T12015 25505-25508 DT denotes the
T12014 25502-25504 IN denotes in
T12013 25496-25501 NN denotes cells
T12012 25488-25495 JJ denotes myeloid
T12011 25485-25487 IN denotes in
T12010 25474-25484 NN denotes expression
T12009 25470-25473 NN denotes A20
T12008 25467-25469 IN denotes of
T12007 25454-25466 NN denotes contribution
T12006 25450-25453 DT denotes the
T12005 25437-25449 VB denotes investigated
T12004 25432-25436 VB denotes have
T12003 25429-25431 PRP denotes we
T12002 25423-25428 NN denotes study
T12001 25415-25422 JJ denotes present
T12000 25411-25414 DT denotes the
T11999 25408-25410 IN denotes In
T12046 25708-25713 NN denotes naïve
T12045 25702-25707 IN denotes Under
T12044 25689-25700 NN denotes macrophages
T12043 25680-25688 JJ denotes alveolar
T12042 25677-25679 IN denotes as
T12041 25674-25676 TO denotes to
T12040 25665-25673 VB denotes referred
T12039 25661-25664 VB denotes are
T12038 25656-25660 PRP denotes they
T12037 25650-25655 WRB denotes where
T12036 25644-25649 NN denotes lumen
T12035 25635-25643 JJ denotes alveolar
T8926 17624-17627 NN denotes A20
R1 T69 T70 arg1Of A20,(
R2 T71 T70 arg2Of Tnfaip3,(
R3 T72 T70 arg3Of ),(
R4 T73 T69 arg1Of Deficiency,A20
R5 T73 T74 arg1Of Deficiency,in
R6 T73 T78 arg1Of Deficiency,against
R7 T77 T74 arg2Of Protects,in
R8 T77 T75 arg1Of Protects,Myeloid
R9 T77 T76 arg1Of Protects,Cells
R10 T82 T78 arg2Of Infection,against
R11 T82 T79 arg1Of Infection,Influenza
R12 T82 T80 arg1Of Infection,A
R13 T82 T81 arg1Of Infection,Virus
R14 T86 T83 arg1Of response,The
R15 T86 T84 arg1Of response,innate
R16 T86 T85 arg1Of response,immune
R17 T86 T87 arg1Of response,provides
R18 T86 T99 arg1Of response,responding
R19 T87 T98 arg1Of provides,by
R20 T90 T87 arg2Of line,provides
R21 T90 T88 arg1Of line,the
R22 T90 T89 arg1Of line,first
R23 T90 T91 arg1Of line,of
R24 T90 T93 arg1Of line,against
R25 T92 T91 arg2Of defense,of
R26 T94 T95 arg1Of viruses,and
R27 T95 T93 arg2Of and,against
R28 T97 T95 arg2Of pathogens,and
R29 T97 T96 arg1Of pathogens,other
R30 T99 T98 arg2Of responding,by
R31 T99 T100 arg1Of responding,to
R32 T103 T100 arg2Of molecules,to
R33 T103 T101 arg1Of molecules,specific
R34 T103 T102 arg1Of molecules,microbial
R35 T106 T104 arg1Of virus,Influenza
R36 T106 T105 arg1Of virus,A
R37 T106 T107 arg1Of virus,(
R38 T106 T110 arg1Of virus,produces
R39 T108 T107 arg2Of IAV,(
R40 T109 T107 arg3Of ),(
R41 T110 T113 arg1Of produces,as
R42 T112 T110 arg2Of RNA,produces
R43 T112 T111 arg1Of RNA,double-stranded
R44 T115 T113 arg2Of intermediate,as
R45 T115 T114 arg1Of intermediate,an
R46 T115 T116 arg1Of intermediate,during
R47 T120 T116 arg2Of cycle,during
R48 T120 T117 arg1Of cycle,the
R49 T120 T118 arg1Of cycle,replication
R50 T120 T119 arg1Of cycle,life
R51 T120 T121 arg1Of cycle,","
R52 T120 T122 arg1Of cycle,which
R53 T120 T123 arg1Of cycle,activates
R54 T120 T131 arg1Of cycle,induces
R55 T123 T130 arg1Of activates,and
R56 T129 T123 arg2Of RIG-I,activates
R57 T129 T124 arg1Of RIG-I,the
R58 T129 T125 arg1Of RIG-I,intracellular
R59 T129 T126 arg1Of RIG-I,pathogen
R60 T129 T127 arg1Of RIG-I,recognition
R61 T129 T128 arg1Of RIG-I,receptor
R62 T131 T130 arg2Of induces,and
R63 T133 T131 arg2Of production,induces
R64 T133 T132 arg1Of production,the
R65 T133 T134 arg1Of production,of
R66 T136 T135 arg1Of cytokines,proinflammatory
R67 T136 T137 arg1Of cytokines,and
R68 T137 T134 arg2Of and,of
R69 T139 T137 arg2Of interferon,and
R70 T139 T138 arg1Of interferon,antiviral
R71 T140 T153 arg1Of Understanding,is
R72 T140 T154 arg1Of Understanding,of
R73 T142 T140 arg2Of mechanisms,Understanding
R74 T142 T141 arg1Of mechanisms,the
R75 T142 T143 arg1Of mechanisms,that
R76 T142 T144 arg1Of mechanisms,regulate
R77 T147 T144 arg2Of responses,regulate
R78 T147 T145 arg1Of responses,innate
R79 T147 T146 arg1Of responses,immune
R80 T147 T148 arg1Of responses,to
R81 T149 T150 arg1Of IAV,and
R82 T150 T148 arg2Of and,to
R83 T152 T150 arg2Of viruses,and
R84 T152 T151 arg1Of viruses,other
R85 T153 T157 modOf is,to
R86 T154 T153 arg2Of of,is
R87 T156 T154 arg2Of importance,of
R88 T156 T155 arg1Of importance,key
R89 T158 T157 arg1Of develop,to
R90 T161 T158 arg2Of strategies,develop
R91 T161 T159 arg1Of strategies,novel
R92 T161 T160 arg1Of strategies,therapeutic
R93 T163 T164 arg1Of we,used
R94 T163 T172 arg1Of we,examine
R95 T164 T162 arg1Of used,Here
R96 T164 T171 modOf used,to
R97 T170 T164 arg2Of mice,used
R98 T170 T165 arg1Of mice,myeloid
R99 T170 T166 arg1Of mice,cell
R100 T170 T167 arg1Of mice,specific
R101 T170 T168 arg1Of mice,A20
R102 T170 T169 arg1Of mice,knockout
R103 T172 T171 arg1Of examine,to
R104 T174 T172 arg2Of role,examine
R105 T174 T173 arg1Of role,the
R106 T174 T175 arg1Of role,of
R107 T174 T180 arg1Of role,in
R108 T179 T175 arg2Of A20,of
R109 T179 T176 arg1Of A20,the
R110 T179 T177 arg1Of A20,ubiquitin-editing
R111 T179 T178 arg1Of A20,protein
R112 T182 T180 arg2Of response,in
R113 T182 T181 arg1Of response,the
R114 T182 T183 arg1Of response,of
R115 T182 T186 arg1Of response,to
R116 T185 T183 arg2Of cells,of
R117 T185 T184 arg1Of cells,myeloid
R118 T188 T186 arg2Of infection,to
R119 T188 T187 arg1Of infection,IAV
R120 T191 T189 arg1Of macrophages,A20
R121 T191 T190 arg1Of macrophages,deficient
R122 T191 T192 arg1Of macrophages,were
R123 T191 T193 arg1Of macrophages,hyperresponsive
R124 T191 T195 arg1Of macrophages,double
R125 T192 T201 arg1Of were,","
R126 T192 T202 arg1Of were,as
R127 T193 T192 arg2Of hyperresponsive,were
R128 T195 T193 arg2Of double,hyperresponsive
R129 T195 T194 arg1Of double,to
R130 T197 T198 arg1Of RNA,and
R131 T199 T198 arg2Of IAV,and
R132 T200 T195 arg2Of infection,double
R133 T200 T196 arg1Of infection,stranded
R134 T200 T197 arg1Of infection,RNA
R135 T200 T199 arg1Of infection,IAV
R136 T203 T202 arg2Of illustrated,as
R137 T206 T205 arg2Of NF-κB,enhanced
R138 T206 T207 arg1Of NF-κB,and
R139 T207 T203 arg1Of and,illustrated
R140 T207 T204 arg2Of and,by
R141 T207 T210 arg1Of and,","
R142 T207 T211 arg1Of and,concomitant
R143 T209 T207 arg2Of activation,and
R144 T209 T208 arg1Of activation,IRF3
R145 T211 T212 arg1Of concomitant,with
R146 T214 T212 arg2Of production,with
R147 T214 T213 arg2Of production,increased
R148 T214 T215 arg1Of production,of
R149 T217 T216 arg1Of cytokines,proinflammatory
R150 T217 T218 arg1Of cytokines,","
R151 T218 T220 arg1Of ",",and
R152 T219 T218 arg2Of chemokines,","
R153 T220 T215 arg2Of and,of
R154 T223 T220 arg2Of interferon,and
R155 T223 T221 arg1Of interferon,type
R156 T223 T222 arg1Of interferon,I
R157 T225 T224 arg1Of vivo,In
R158 T226 T227 arg1Of this,was
R159 T226 T228 arg2Of this,associated
R160 T228 T225 arg1Of associated,vivo
R161 T228 T227 arg2Of associated,was
R162 T228 T229 arg1Of associated,with
R163 T232 T229 arg2Of number,with
R164 T232 T230 arg1Of number,an
R165 T232 T231 arg2Of number,increased
R166 T232 T233 arg1Of number,of
R167 T232 T238 arg1Of number,in
R168 T235 T234 arg1Of macrophages,alveolar
R169 T235 T236 arg1Of macrophages,and
R170 T236 T233 arg2Of and,of
R171 T237 T236 arg2Of neutrophils,and
R172 T240 T238 arg2Of lungs,in
R173 T240 T239 arg1Of lungs,the
R174 T240 T241 arg1Of lungs,of
R175 T244 T241 arg2Of mice,of
R176 T244 T242 arg1Of mice,IAV
R177 T244 T243 arg1Of mice,infected
R178 T252 T247 arg1Of mice,myeloid
R179 T252 T248 arg1Of mice,cell
R180 T252 T249 arg1Of mice,specific
R181 T252 T250 arg1Of mice,A20
R182 T252 T251 arg1Of mice,knockout
R183 T252 T253 arg1Of mice,are
R184 T252 T254 arg2Of mice,protected
R185 T254 T245 arg1Of protected,Surprisingly
R186 T254 T246 arg1Of protected,","
R187 T254 T253 arg2Of protected,are
R188 T254 T255 arg1Of protected,against
R189 T258 T255 arg2Of infection,against
R190 T258 T256 arg1Of infection,lethal
R191 T258 T257 arg1Of infection,IAV
R192 T260 T259 arg1Of results,These
R193 T260 T261 arg1Of results,challenge
R194 T264 T261 arg2Of belief,challenge
R195 T264 T262 arg1Of belief,the
R196 T264 T263 arg1Of belief,general
R197 T270 T266 arg1Of response,an
R198 T270 T267 arg1Of response,excessive
R199 T270 T268 arg1Of response,host
R200 T270 T269 arg1Of response,proinflammatory
R201 T270 T271 arg1Of response,is
R202 T270 T272 arg2Of response,associated
R203 T270 T278 arg1Of response,suggest
R204 T272 T271 arg2Of associated,is
R205 T272 T273 arg1Of associated,with
R206 T272 T277 arg1Of associated,and
R207 T275 T273 arg2Of lethality,with
R208 T275 T274 arg1Of lethality,IAV-induced
R209 T277 T264 arg2Of and,belief
R210 T277 T265 arg1Of and,that
R211 T277 T276 arg1Of and,","
R212 T278 T277 arg2Of suggest,and
R213 T282 T280 arg2Of conditions,under
R214 T282 T281 arg1Of conditions,certain
R215 T283 T284 arg1Of inhibition,of
R216 T283 T286 arg1Of inhibition,might
R217 T283 T287 arg1Of inhibition,be
R218 T283 T288 arg1Of inhibition,of
R219 T285 T284 arg2Of A20,of
R220 T287 T278 arg2Of be,suggest
R221 T287 T279 arg1Of be,that
R222 T287 T280 arg1Of be,under
R223 T287 T286 arg2Of be,might
R224 T288 T287 arg2Of of,be
R225 T289 T288 arg2Of interest,of
R226 T289 T290 arg1Of interest,in
R227 T292 T290 arg2Of management,in
R228 T292 T291 arg1Of management,the
R229 T292 T293 arg1Of management,of
R230 T295 T293 arg2Of infections,of
R231 T295 T294 arg1Of infections,IAV
R609 T1339 T1340 arg1Of Viruses,are
R610 T1342 T1340 arg2Of class,are
R611 T1342 T1341 arg1Of class,a
R612 T1342 T1343 arg1Of class,of
R613 T1345 T1344 arg1Of diverse,highly
R614 T1346 T1343 arg2Of pathogens,of
R615 T1346 T1345 arg1Of pathogens,diverse
R616 T1346 T1347 arg1Of pathogens,which
R617 T1346 T1348 arg1Of pathogens,depend
R618 T1348 T1349 arg1Of depend,on
R619 T1352 T1349 arg2Of cell,on
R620 T1352 T1350 arg1Of cell,the
R621 T1352 T1351 arg1Of cell,host
R622 T1352 T1353 arg1Of cell,for
R623 T1355 T1353 arg2Of replication,for
R624 T1355 T1354 arg1Of replication,their
R625 T1357 T1356 arg1Of initiation,The
R626 T1357 T1358 arg1Of initiation,of
R627 T1357 T1365 arg1Of initiation,involves
R628 T1364 T1358 arg2Of response,of
R629 T1364 T1359 arg1Of response,a
R630 T1364 T1360 arg1Of response,protective
R631 T1364 T1361 arg1Of response,innate
R632 T1364 T1362 arg1Of response,antiviral
R633 T1364 T1363 arg1Of response,immune
R634 T1367 T1365 arg2Of action,involves
R635 T1367 T1366 arg1Of action,the
R636 T1367 T1368 arg1Of action,of
R637 T1372 T1368 arg2Of receptors,of
R638 T1372 T1369 arg2Of receptors,specialized
R639 T1372 T1370 arg1Of receptors,pattern
R640 T1372 T1371 arg1Of receptors,recognition
R641 T1372 T1373 arg1Of receptors,(
R642 T1372 T1376 arg1Of receptors,","
R643 T1372 T1377 arg1Of receptors,which
R644 T1372 T1378 arg1Of receptors,detect
R645 T1374 T1373 arg2Of PRR,(
R646 T1375 T1373 arg3Of ),(
R647 T1381 T1378 arg2Of structures,detect
R648 T1381 T1379 arg2Of structures,conserved
R649 T1381 T1380 arg1Of structures,molecular
R650 T1381 T1382 arg1Of structures,of
R651 T1385 T1382 arg2Of pathogen,of
R652 T1385 T1383 arg1Of pathogen,the
R653 T1385 T1384 arg1Of pathogen,invading
R654 T1386 T1387 arg1Of Triggering,of
R655 T1386 T1389 arg1Of Triggering,induces
R656 T1388 T1387 arg2Of PRRs,of
R657 T1389 T1416 arg1Of induces,through
R658 T1391 T1389 arg2Of production,induces
R659 T1391 T1390 arg1Of production,the
R660 T1391 T1392 arg1Of production,of
R661 T1395 T1393 arg1Of cytokines,host
R662 T1395 T1394 arg1Of cytokines,proinflammatory
R663 T1395 T1396 arg1Of cytokines,(
R664 T1395 T1404 arg1Of cytokines,and
R665 T1398 T1399 arg1Of TNF,","
R666 T1399 T1401 arg1Of ",",and
R667 T1400 T1399 arg2Of IL-6,","
R668 T1401 T1396 arg2Of and,(
R669 T1401 T1397 arg1Of and,e.g.
R670 T1402 T1401 arg2Of IL-1,and
R671 T1403 T1396 arg3Of ),(
R672 T1404 T1392 arg2Of and,of
R673 T1407 T1404 arg2Of interferons,and
R674 T1407 T1405 arg1Of interferons,type
R675 T1407 T1406 arg1Of interferons,I
R676 T1407 T1408 arg1Of interferons,(
R677 T1409 T1410 arg1Of interferon-α,(
R678 T1409 T1413 arg1Of interferon-α,and
R679 T1411 T1410 arg2Of IFN-α,(
R680 T1412 T1410 arg3Of ),(
R681 T1413 T1408 arg2Of and,(
R682 T1414 T1413 arg2Of IFN-β,and
R683 T1415 T1408 arg3Of ),(
R684 T1417 T1416 arg2Of activation,through
R685 T1417 T1418 arg1Of activation,of
R686 T1421 T1418 arg2Of pathways,of
R687 T1421 T1419 arg1Of pathways,downstream
R688 T1421 T1420 arg1Of pathways,signaling
R689 T1421 T1422 arg1Of pathways,that
R690 T1421 T1423 arg1Of pathways,control
R691 T1423 T1439 arg1Of control,","
R692 T1423 T1440 arg1Of control,[
R693 T1426 T1423 arg2Of factors,control
R694 T1426 T1424 arg1Of factors,various
R695 T1426 T1425 arg1Of factors,transcription
R696 T1426 T1428 arg1Of factors,as
R697 T1428 T1427 arg1Of as,such
R698 T1429 T1430 arg1Of NF-κB,","
R699 T1430 T1432 arg1Of ",",","
R700 T1431 T1430 arg2Of AP-1,","
R701 T1432 T1434 arg1Of ",",and
R702 T1433 T1432 arg2Of IRF3,","
R703 T1434 T1428 arg2Of and,as
R704 T1435 T1434 arg2Of IRF7,and
R705 T1435 T1436 arg1Of IRF7,[
R706 T1437 T1436 arg2Of 1,[
R707 T1438 T1436 arg3Of ],[
R708 T1441 T1440 arg2Of 2,[
R709 T1442 T1440 arg3Of ],[
R710 T1444 T1443 arg1Of presence,The
R711 T1444 T1445 arg1Of presence,of
R712 T1444 T1465 arg1Of presence,can
R713 T1444 T1466 arg1Of presence,be
R714 T1444 T1467 arg2Of presence,sensed
R715 T1448 T1445 arg2Of acids,of
R716 T1448 T1446 arg1Of acids,viral
R717 T1448 T1447 arg1Of acids,nucleic
R718 T1448 T1449 arg1Of acids,","
R719 T1448 T1451 arg1Of acids,as
R720 T1451 T1450 arg1Of as,such
R721 T1453 T1452 arg1Of RNA,viral
R722 T1453 T1454 arg1Of RNA,and
R723 T1454 T1456 arg1Of and,","
R724 T1455 T1454 arg2Of DNA,and
R725 T1456 T1460 arg1Of ",",and
R726 T1459 T1456 arg2Of intermediates,","
R727 T1459 T1457 arg1Of intermediates,viral
R728 T1459 T1458 arg1Of intermediates,replication
R729 T1460 T1451 arg2Of and,as
R730 T1463 T1460 arg2Of products,and
R731 T1463 T1461 arg1Of products,viral
R732 T1463 T1462 arg1Of products,transcription
R733 T1467 T1464 arg1Of sensed,","
R734 T1467 T1465 arg2Of sensed,can
R735 T1467 T1466 arg2Of sensed,be
R736 T1467 T1472 arg1Of sensed,[
R737 T1471 T1467 arg1Of PRRs,sensed
R738 T1471 T1468 arg2Of PRRs,by
R739 T1471 T1469 arg1Of PRRs,specific
R740 T1471 T1470 arg1Of PRRs,intracellular
R741 T1473 T1472 arg2Of 3,[
R742 T1474 T1472 arg3Of ],[
R743 T1477 T1475 arg1Of receptors,Endosomal
R744 T1477 T1476 arg1Of receptors,Toll-like
R745 T1477 T1478 arg1Of receptors,(
R746 T1477 T1481 arg1Of receptors,and
R747 T1479 T1478 arg2Of TLRs,(
R748 T1480 T1478 arg3Of ),(
R749 T1481 T1490 arg1Of and,or
R750 T1486 T1481 arg2Of receptors,and
R751 T1486 T1482 arg1Of receptors,cytoplasmic
R752 T1486 T1483 arg1Of receptors,RNA
R753 T1486 T1484 arg1Of receptors,helicase
R754 T1486 T1485 arg1Of receptors,RIG-I-like
R755 T1486 T1487 arg1Of receptors,(
R756 T1488 T1487 arg2Of RLRs,(
R757 T1489 T1487 arg3Of ),(
R758 T1490 T1496 arg1Of or,detect
R759 T1492 T1490 arg2Of receptors,or
R760 T1492 T1491 arg1Of receptors,Nod-like
R761 T1492 T1493 arg1Of receptors,(
R762 T1494 T1493 arg2Of NLRs,(
R763 T1495 T1493 arg3Of ),(
R764 T1498 T1496 arg2Of presence,detect
R765 T1498 T1497 arg1Of presence,the
R766 T1498 T1499 arg1Of presence,of
R767 T1502 T1500 arg1Of stranded,viral
R768 T1502 T1501 arg1Of stranded,single
R769 T1504 T1502 arg1Of TLR7,stranded
R770 T1504 T1503 arg2Of TLR7,(
R771 T1504 T1505 arg1Of TLR7,","
R772 T1504 T1507 arg1Of TLR7,","
R773 T1504 T1510 arg1Of TLR7,or
R774 T1506 T1505 arg2Of TLR8,","
R775 T1508 T1507 arg2Of Nod2,","
R776 T1509 T1503 arg3Of ),(
R777 T1510 T1499 arg2Of or,of
R778 T1513 T1510 arg2Of RNA,or
R779 T1513 T1511 arg1Of RNA,double
R780 T1513 T1512 arg1Of RNA,stranded
R781 T1513 T1514 arg1Of RNA,(
R782 T1515 T1514 arg2Of TLR3,(
R783 T1515 T1516 arg1Of TLR3,","
R784 T1515 T1518 arg1Of TLR3,","
R785 T1517 T1516 arg2Of RIG-I,","
R786 T1519 T1518 arg2Of MDA5,","
R787 T1520 T1514 arg3Of ),(
R788 T1523 T1521 arg1Of sensors,Intracellular
R789 T1523 T1522 arg1Of sensors,DNA
R790 T1523 T1524 arg1Of sensors,that
R791 T1523 T1525 arg1Of sensors,mediate
R792 T1523 T1532 arg1Of sensors,include
R793 T1528 T1525 arg2Of responses,mediate
R794 T1528 T1526 arg1Of responses,antiviral
R795 T1528 T1527 arg1Of responses,immune
R796 T1528 T1529 arg1Of responses,to
R797 T1531 T1529 arg2Of viruses,to
R798 T1531 T1530 arg1Of viruses,DNA
R799 T1533 T1534 arg1Of TLR9,","
R800 T1533 T1539 arg1Of TLR9,and
R801 T1535 T1534 arg2Of DAI,","
R802 T1535 T1536 arg1Of DAI,[
R803 T1537 T1536 arg2Of 4,[
R804 T1538 T1536 arg3Of ],[
R805 T1539 T1532 arg2Of and,include
R806 T1542 T1541 arg1Of domain,PYHIN
R807 T1542 T1543 arg1Of domain,containing
R808 T1542 T1557 arg1Of domain,and
R809 T1543 T1554 arg1Of containing,[
R810 T1545 T1543 arg2Of AIM2,containing
R811 T1545 T1544 arg1Of AIM2,proteins
R812 T1545 T1546 arg1Of AIM2,[
R813 T1545 T1549 arg1Of AIM2,","
R814 T1545 T1550 arg1Of AIM2,[
R815 T1545 T1553 arg1Of AIM2,","
R816 T1547 T1546 arg2Of 5,[
R817 T1548 T1546 arg3Of ],[
R818 T1551 T1550 arg2Of 6,[
R819 T1552 T1550 arg3Of ],[
R820 T1555 T1554 arg2Of 7,[
R821 T1556 T1554 arg3Of ],[
R822 T1557 T1539 arg2Of and,and
R823 T1557 T1540 arg1Of and,the
R824 T1558 T1557 arg2Of IFI16,and
R825 T1558 T1559 arg1Of IFI16,[
R826 T1560 T1559 arg2Of 8,[
R827 T1561 T1559 arg3Of ],[
R828 T1565 T1563 arg2Of responses,mediated
R829 T1565 T1564 arg1Of responses,antiviral
R830 T1565 T1566 arg1Of responses,are
R831 T1565 T1567 arg1Of responses,restricted
R832 T1566 T1562 arg1Of are,TLR
R833 T1567 T1566 arg2Of restricted,are
R834 T1567 T1568 arg1Of restricted,to
R835 T1572 T1568 arg2Of IFN,to
R836 T1572 T1569 arg2Of IFN,specialized
R837 T1572 T1570 arg1Of IFN,type
R838 T1572 T1571 arg1Of IFN,I
R839 T1572 T1573 arg1Of IFN,producing
R840 T1573 T1580 arg1Of producing,","
R841 T1573 T1581 arg1Of producing,while
R842 T1576 T1573 arg2Of cells,producing
R843 T1576 T1574 arg1Of cells,plasmacytoid
R844 T1576 T1575 arg1Of cells,dendritic
R845 T1576 T1577 arg1Of cells,(
R846 T1578 T1577 arg2Of pDC,(
R847 T1579 T1577 arg3Of ),(
R848 T1585 T1582 arg1Of types,most
R849 T1585 T1583 arg1Of types,other
R850 T1585 T1584 arg1Of types,cell
R851 T1585 T1586 arg1Of types,","
R852 T1585 T1587 arg1Of types,including
R853 T1585 T1593 arg1Of types,","
R854 T1589 T1587 arg2Of DC,including
R855 T1589 T1588 arg1Of DC,conventional
R856 T1589 T1590 arg1Of DC,(
R857 T1591 T1590 arg2Of cDC,(
R858 T1592 T1590 arg3Of ),(
R859 T1593 T1598 arg1Of ",",depend
R860 T1594 T1595 arg1Of macrophages,and
R861 T1595 T1593 arg2Of and,","
R862 T1596 T1595 arg2Of fibroblasts,and
R863 T1598 T1581 arg2Of depend,while
R864 T1598 T1597 arg1Of depend,","
R865 T1598 T1599 arg1Of depend,on
R866 T1602 T1603 arg1Of RNA,and
R867 T1604 T1603 arg2Of DNA,and
R868 T1605 T1599 arg2Of sensors,on
R869 T1605 T1600 arg1Of sensors,the
R870 T1605 T1601 arg1Of sensors,cytosolic
R871 T1605 T1602 arg1Of sensors,RNA
R872 T1605 T1604 arg1Of sensors,DNA
R873 T1605 T1606 arg1Of sensors,for
R874 T1608 T1606 arg2Of production,for
R875 T1608 T1607 arg1Of production,the
R876 T1608 T1609 arg1Of production,of
R877 T1608 T1612 arg1Of production,[
R878 T1611 T1609 arg2Of proteins,of
R879 T1611 T1610 arg1Of proteins,antiviral
R880 T1613 T1612 arg2Of 9,[
R881 T1614 T1612 arg3Of ],[
R882 T1617 T1615 arg1Of virus,Influenza
R883 T1617 T1616 arg1Of virus,A
R884 T1617 T1618 arg1Of virus,(
R885 T1617 T1621 arg1Of virus,is
R886 T1619 T1618 arg2Of IAV,(
R887 T1620 T1618 arg3Of ),(
R888 T1624 T1621 arg2Of agent,is
R889 T1624 T1622 arg1Of agent,the
R890 T1624 T1623 arg1Of agent,etiological
R891 T1624 T1625 arg1Of agent,of
R892 T1630 T1625 arg2Of disease,of
R893 T1630 T1626 arg1Of disease,a
R894 T1630 T1627 arg1Of disease,contagious
R895 T1630 T1628 arg1Of disease,acute
R896 T1630 T1629 arg1Of disease,respiratory
R897 T1630 T1631 arg1Of disease,that
R898 T1630 T1632 arg1Of disease,causes
R899 T1634 T1632 arg2Of mortality,causes
R900 T1634 T1633 arg1Of mortality,considerable
R901 T1634 T1635 arg1Of mortality,","
R902 T1634 T1636 arg1Of mortality,which
R903 T1634 T1637 arg1Of mortality,is
R904 T1634 T1639 arg2Of mortality,believed
R905 T1634 T1641 arg1Of mortality,be
R906 T1634 T1643 arg1Of mortality,to
R907 T1639 T1637 arg2Of believed,is
R908 T1639 T1638 arg1Of believed,generally
R909 T1641 T1639 arg3Of be,believed
R910 T1641 T1640 arg1Of be,to
R911 T1643 T1641 arg2Of to,be
R912 T1643 T1642 arg1Of to,due
R913 T1648 T1643 arg2Of response,to
R914 T1648 T1644 arg1Of response,an
R915 T1648 T1645 arg1Of response,excessive
R916 T1648 T1646 arg1Of response,host
R917 T1648 T1647 arg1Of response,inflammatory
R918 T1649 T1650 arg1Of Emergence,of
R919 T1649 T1659 arg1Of Emergence,underscores
R920 T1652 T1650 arg2Of strains,of
R921 T1652 T1651 arg1Of strains,drug-resistant
R922 T1652 T1653 arg1Of strains,of
R923 T1655 T1653 arg2Of viruses,of
R924 T1655 T1654 arg1Of viruses,influenza
R925 T1655 T1656 arg1Of viruses,with
R926 T1658 T1656 arg2Of potential,with
R927 T1658 T1657 arg1Of potential,pandemic
R928 T1661 T1659 arg2Of importance,underscores
R929 T1661 T1660 arg1Of importance,the
R930 T1661 T1662 arg1Of importance,of
R931 T1666 T1662 arg2Of strategies,of
R932 T1666 T1663 arg1Of strategies,developing
R933 T1666 T1664 arg1Of strategies,novel
R934 T1666 T1665 arg1Of strategies,antiviral
R935 T1669 T1667 arg2Of context,In
R936 T1669 T1668 arg1Of context,this
R937 T1671 T1672 arg1Of understanding,of
R938 T1671 T1680 arg1Of understanding,is
R939 T1671 T1681 arg1Of understanding,critical
R940 T1674 T1672 arg2Of mechanisms,of
R941 T1674 T1673 arg1Of mechanisms,the
R942 T1674 T1675 arg1Of mechanisms,that
R943 T1674 T1676 arg1Of mechanisms,regulate
R944 T1679 T1676 arg2Of responses,regulate
R945 T1679 T1677 arg1Of responses,IAV-induced
R946 T1679 T1678 arg1Of responses,immune
R947 T1680 T1667 arg1Of is,In
R948 T1680 T1670 arg1Of is,","
R949 T1681 T1680 arg2Of critical,is
R950 T1683 T1682 arg1Of infection,IAV
R951 T1683 T1684 arg1Of infection,leads
R952 T1684 T1685 arg1Of leads,to
R953 T1687 T1685 arg2Of exposure,to
R954 T1687 T1686 arg1Of exposure,the
R955 T1687 T1688 arg1Of exposure,in
R956 T1687 T1700 arg1Of exposure,","
R957 T1691 T1688 arg2Of cell,in
R958 T1691 T1689 arg1Of cell,the
R959 T1691 T1690 arg1Of cell,host
R960 T1691 T1692 arg1Of cell,of
R961 T1695 T1693 arg1Of RNA,single-stranded
R962 T1695 T1694 arg1Of RNA,genomic
R963 T1695 T1696 arg1Of RNA,and
R964 T1696 T1692 arg2Of and,of
R965 T1699 T1696 arg2Of RNA,and
R966 T1699 T1697 arg1Of RNA,double
R967 T1699 T1698 arg1Of RNA,stranded
R968 T1702 T1700 arg2Of latter,","
R969 T1702 T1701 arg1Of latter,the
R970 T1703 T1684 arg2Of being,leads
R971 T1705 T1703 arg2Of intermediate,being
R972 T1705 T1704 arg1Of intermediate,an
R973 T1705 T1706 arg1Of intermediate,of
R974 T1708 T1706 arg2Of replication,of
R975 T1708 T1707 arg1Of replication,viral
R976 T1709 T1710 arg1Of TLR3,and
R977 T1710 T1712 arg1Of and,have
R978 T1710 T1713 arg1Of and,been
R979 T1710 T1714 arg2Of and,implicated
R980 T1711 T1710 arg2Of RIG-I,and
R981 T1714 T1712 arg2Of implicated,have
R982 T1714 T1713 arg2Of implicated,been
R983 T1714 T1715 arg1Of implicated,as
R984 T1714 T1720 arg1Of implicated,[
R985 T1716 T1715 arg2Of sensors,as
R986 T1716 T1717 arg1Of sensors,of
R987 T1719 T1717 arg2Of infection,of
R988 T1719 T1718 arg1Of infection,IAV
R989 T1721 T1720 arg2Of 10,[
R990 T1722 T1720 arg3Of ],[
R991 T1723 T1714 arg3Of –,implicated
R992 T1723 T1724 arg1Of –,[
R993 T1725 T1724 arg2Of 12,[
R994 T1726 T1724 arg3Of ],[
R995 T1728 T1727 arg1Of receptors,Both
R996 T1728 T1729 arg1Of receptors,contribute
R997 T1729 T1730 arg1Of contribute,to
R998 T1729 T1737 arg1Of contribute,but
R999 T1733 T1730 arg2Of response,to
R1000 T1733 T1731 arg1Of response,the
R1001 T1733 T1732 arg1Of response,proinflammatory
R1002 T1733 T1734 arg1Of response,to
R1003 T1735 T1734 arg2Of IAV,to
R1004 T1737 T1736 arg1Of but,","
R1005 T1739 T1738 arg1Of initiation,the
R1006 T1739 T1740 arg1Of initiation,of
R1007 T1739 T1747 arg1Of initiation,depends
R1008 T1745 T1740 arg2Of response,of
R1009 T1745 T1741 arg1Of response,the
R1010 T1745 T1742 arg1Of response,innate
R1011 T1745 T1743 arg1Of response,antiviral
R1012 T1745 T1744 arg1Of response,immune
R1013 T1747 T1737 arg2Of depends,but
R1014 T1747 T1746 arg1Of depends,largely
R1015 T1747 T1748 arg1Of depends,on
R1016 T1747 T1752 arg1Of depends,[
R1017 T1751 T1748 arg2Of signaling,on
R1018 T1751 T1749 arg1Of signaling,RIG-I
R1019 T1751 T1750 arg2Of signaling,mediated
R1020 T1753 T1752 arg2Of 13,[
R1021 T1754 T1752 arg3Of ],[
R1022 T1759 T1757 arg1Of mice,RIG-I
R1023 T1759 T1758 arg1Of mice,deficient
R1024 T1759 T1760 arg1Of mice,are
R1025 T1759 T1762 arg1Of mice,susceptible
R1026 T1760 T1755 arg1Of are,Interestingly
R1027 T1760 T1756 arg1Of are,","
R1028 T1760 T1768 arg1Of are,","
R1029 T1760 T1769 arg1Of are,[
R1030 T1760 T1772 arg1Of are,","
R1031 T1760 T1773 arg1Of are,whereas
R1032 T1762 T1760 arg2Of susceptible,are
R1033 T1762 T1761 arg1Of susceptible,highly
R1034 T1762 T1763 arg1Of susceptible,to
R1035 T1764 T1763 arg2Of IAV,to
R1036 T1764 T1765 arg1Of IAV,[
R1037 T1766 T1765 arg2Of 14,[
R1038 T1767 T1765 arg3Of ],[
R1039 T1770 T1769 arg2Of 15,[
R1040 T1771 T1769 arg3Of ],[
R1041 T1776 T1774 arg1Of mice,TLR3
R1042 T1776 T1775 arg1Of mice,deficient
R1043 T1776 T1777 arg1Of mice,have
R1044 T1777 T1773 arg2Of have,whereas
R1045 T1777 T1781 arg1Of have,to
R1046 T1780 T1777 arg2Of advantage,have
R1047 T1780 T1778 arg1Of advantage,a
R1048 T1780 T1779 arg1Of advantage,survival
R1049 T1783 T1781 arg2Of infection,to
R1050 T1783 T1782 arg1Of infection,acute
R1051 T1783 T1784 arg1Of infection,[
R1052 T1785 T1784 arg2Of 16,[
R1053 T1786 T1784 arg3Of ],[
R1054 T1788 T1787 arg1Of results,These
R1055 T1788 T1789 arg1Of results,indicate
R1056 T1792 T1791 arg1Of imbalance,an
R1057 T1792 T1793 arg1Of imbalance,between
R1058 T1792 T1805 arg1Of imbalance,is
R1059 T1792 T1806 arg1Of imbalance,likely
R1060 T1792 T1808 arg1Of imbalance,contribute
R1061 T1795 T1796 arg1Of beneficial,and
R1062 T1797 T1796 arg2Of harmful,and
R1063 T1798 T1793 arg2Of effects,between
R1064 T1798 T1794 arg1Of effects,the
R1065 T1798 T1795 arg1Of effects,beneficial
R1066 T1798 T1797 arg1Of effects,harmful
R1067 T1798 T1799 arg1Of effects,of
R1068 T1800 T1799 arg2Of mediators,of
R1069 T1800 T1801 arg2Of mediators,released
R1070 T1804 T1801 arg1Of cells,released
R1071 T1804 T1802 arg2Of cells,by
R1072 T1804 T1803 arg1Of cells,immune
R1073 T1805 T1789 arg2Of is,indicate
R1074 T1805 T1790 arg1Of is,that
R1075 T1806 T1805 arg2Of likely,is
R1076 T1808 T1806 arg2Of contribute,likely
R1077 T1808 T1807 arg1Of contribute,to
R1078 T1808 T1809 arg1Of contribute,to
R1079 T1811 T1809 arg2Of pathogenesis,to
R1080 T1811 T1810 arg1Of pathogenesis,the
R1081 T1811 T1812 arg1Of pathogenesis,of
R1082 T1813 T1812 arg2Of influenza,of
R1083 T1814 T1815 arg1Of RIG-I,contains
R1084 T1821 T1815 arg2Of domain,contains
R1085 T1821 T1816 arg1Of domain,a
R1086 T1821 T1817 arg1Of domain,C-terminal
R1087 T1821 T1818 arg1Of domain,DExD/H
R1088 T1821 T1819 arg1Of domain,box
R1089 T1821 T1820 arg1Of domain,helicase
R1090 T1821 T1822 arg1Of domain,","
R1091 T1821 T1823 arg1Of domain,which
R1092 T1821 T1824 arg1Of domain,is
R1093 T1821 T1825 arg2Of domain,required
R1094 T1825 T1824 arg2Of required,is
R1095 T1825 T1826 arg1Of required,for
R1096 T1828 T1827 arg1Of recognition,ligand
R1097 T1828 T1830 arg1Of recognition,and
R1098 T1830 T1826 arg2Of and,for
R1099 T1830 T1829 arg1Of and,","
R1100 T1834 T1830 arg2Of domains,and
R1101 T1834 T1831 arg1Of domains,two
R1102 T1834 T1832 arg1Of domains,N-terminal
R1103 T1834 T1833 arg1Of domains,CARD
R1104 T1837 T1835 arg2Of binding,Upon
R1105 T1837 T1836 arg1Of binding,ligand
R1106 T1841 T1839 arg1Of domains,the
R1107 T1841 T1840 arg1Of domains,CARD
R1108 T1841 T1842 arg1Of domains,of
R1109 T1841 T1844 arg1Of domains,associate
R1110 T1843 T1842 arg2Of RIG-I,of
R1111 T1844 T1835 arg1Of associate,Upon
R1112 T1844 T1838 arg1Of associate,","
R1113 T1844 T1845 arg1Of associate,with
R1114 T1848 T1845 arg2Of domain,with
R1115 T1848 T1846 arg1Of domain,the
R1116 T1848 T1847 arg1Of domain,CARD
R1117 T1848 T1849 arg1Of domain,of
R1118 T1851 T1852 arg1Of MAVS,(
R1119 T1854 T1852 arg2Of termed,(
R1120 T1854 T1853 arg1Of termed,also
R1121 T1855 T1854 arg3Of IPS-1,termed
R1122 T1855 T1856 arg1Of IPS-1,","
R1123 T1855 T1858 arg1Of IPS-1,","
R1124 T1855 T1859 arg1Of IPS-1,Cardif
R1125 T1857 T1856 arg2Of VISA,","
R1126 T1860 T1852 arg3Of ),(
R1127 T1862 T1849 arg2Of protein,of
R1128 T1862 T1850 arg1Of protein,the
R1129 T1862 T1851 arg1Of protein,MAVS
R1130 T1862 T1861 arg1Of protein,adaptor
R1131 T1862 T1863 arg1Of protein,","
R1132 T1862 T1864 arg1Of protein,which
R1133 T1862 T1866 arg1Of protein,translocates
R1134 T1866 T1865 arg1Of translocates,subsequently
R1135 T1866 T1867 arg1Of translocates,to
R1136 T1866 T1870 arg1Of translocates,in
R1137 T1866 T1875 arg1Of translocates,via
R1138 T1866 T1880 arg1Of translocates,[
R1139 T1866 T1884 arg1Of translocates,[
R1140 T1869 T1867 arg2Of inserts,to
R1141 T1869 T1868 arg1Of inserts,and
R1142 T1874 T1870 arg2Of membrane,in
R1143 T1874 T1871 arg1Of membrane,the
R1144 T1874 T1872 arg1Of membrane,outer
R1145 T1874 T1873 arg1Of membrane,mitochondrial
R1146 T1879 T1875 arg2Of domain,via
R1147 T1879 T1876 arg1Of domain,its
R1148 T1879 T1877 arg1Of domain,C-terminal
R1149 T1879 T1878 arg1Of domain,transmembrane
R1150 T1881 T1880 arg2Of 17,[
R1151 T1882 T1880 arg3Of ],[
R1152 T1883 T1866 arg2Of –,translocates
R1153 T1885 T1884 arg2Of 20,[
R1154 T1886 T1884 arg3Of ],[
R1155 T1887 T1888 arg1Of Signaling,downstream
R1156 T1887 T1891 arg1Of Signaling,requires
R1157 T1888 T1889 arg1Of downstream,of
R1158 T1890 T1889 arg2Of MAVS,of
R1159 T1893 T1891 arg2Of action,requires
R1160 T1893 T1892 arg1Of action,the
R1161 T1893 T1894 arg1Of action,of
R1162 T1893 T1897 arg1Of action,modifying
R1163 T1896 T1894 arg2Of ubiquitin,of
R1164 T1948 T1947 arg1Of characterized,well
R1165 T1896 T1895 arg1Of ubiquitin,various
R1166 T1898 T1897 arg2Of enzymes,modifying
R1167 T1950 T1948 arg1Of ligases,characterized
R1168 T1950 T1949 arg1Of ligases,ubiquitin
R1169 T1950 T1952 arg1Of ligases,as
R1170 T1950 T1961 arg1Of ligases,and
R1171 T1898 T1899 arg1Of enzymes,","
R1172 T1898 T1900 arg1Of enzymes,which
R1173 T1952 T1951 arg1Of as,such
R1174 T1953 T1952 arg2Of TRAF6,as
R1175 T1953 T1954 arg1Of TRAF6,[
R1176 T1953 T1957 arg1Of TRAF6,","
R1177 T1953 T1958 arg1Of TRAF6,[
R1178 T1955 T1954 arg2Of 25,[
R1179 T1898 T1905 arg1Of enzymes,regulate
R1180 T1956 T1954 arg3Of ],[
R1181 T1902 T1903 arg1Of positively,and
R1182 T1959 T1958 arg2Of 26,[
R1183 T1960 T1958 arg3Of ],[
R1184 T1961 T1966 arg1Of and,mediate
R1185 T1962 T1961 arg2Of TRAF3,and
R1186 T1962 T1963 arg1Of TRAF3,[
R1187 T1903 T1901 arg1Of and,both
R1188 T1964 T1963 arg2Of 27,[
R1189 T1965 T1963 arg3Of ],[
R1190 T1966 T1944 arg1Of mediate,In
R1191 T1966 T1946 arg1Of mediate,","
R1192 T1966 T1967 arg1Of mediate,respectively
R1193 T1966 T1972 arg1Of mediate,upon
R1194 T1904 T1903 arg2Of negatively,and
R1195 T1968 T1969 arg1Of NF-κB,and
R1196 T1969 T1966 arg2Of and,mediate
R1197 T1905 T1902 arg1Of regulate,positively
R1198 T1971 T1969 arg2Of activation,and
R1199 T1971 T1970 arg1Of activation,IRF3
R1200 T1905 T1904 arg1Of regulate,negatively
R1201 T1909 T1905 arg2Of transduction,regulate
R1202 T1974 T1972 arg2Of stimulation,upon
R1203 T1974 T1973 arg1Of stimulation,RIG-I
R1204 T1978 T1975 arg2Of hand,On
R1205 T1978 T1976 arg1Of hand,the
R1206 T1978 T1977 arg1Of hand,other
R1207 T1980 T1998 arg1Of deubiquitinating,[
R1208 T1980 T2001 arg1Of deubiquitinating,and
R1209 T1981 T1980 arg2Of enzymes,deubiquitinating
R1210 T1981 T1982 arg1Of enzymes,(
R1211 T1981 T1985 arg1Of enzymes,","
R1212 T1981 T1987 arg1Of enzymes,as
R1213 T1981 T1997 arg1Of enzymes,","
R1214 T1909 T1906 arg1Of transduction,RIG-I
R1215 T1983 T1982 arg2Of DUBs,(
R1216 T1909 T1907 arg1Of transduction,mediated
R1217 T1984 T1982 arg3Of ),(
R1218 T1909 T1908 arg1Of transduction,signal
R1219 T1909 T1910 arg1Of transduction,[
R1220 T1911 T1910 arg2Of 21,[
R1221 T1987 T1986 arg1Of as,such
R1222 T1988 T1989 arg1Of DUBA,[
R1223 T1988 T1992 arg1Of DUBA,","
R1224 T1990 T1989 arg2Of 28,[
R1225 T1991 T1989 arg3Of ],[
R1226 T1992 T1987 arg2Of ",",as
R1227 T1993 T1992 arg2Of CYLD,","
R1228 T1993 T1994 arg1Of CYLD,[
R1229 T1995 T1994 arg2Of 29,[
R1230 T1912 T1910 arg3Of ],[
R1231 T1996 T1994 arg3Of ],[
R1232 T1915 T1913 arg1Of ligases,K63-specific
R1233 T1999 T1998 arg2Of 30,[
R1234 T2000 T1998 arg3Of ],[
R1235 T2001 T2006 arg1Of and,have
R1236 T2001 T2007 arg1Of and,been
R1237 T2001 T2008 arg2Of and,shown
R1238 T2001 T2011 arg1Of and,regulate
R1239 T2002 T2001 arg2Of OTUB1/2,and
R1240 T2002 T2003 arg1Of OTUB1/2,[
R1241 T2004 T2003 arg2Of 31,[
R1242 T1915 T1914 arg1Of ligases,ubiquitin
R1243 T2005 T2003 arg3Of ],[
R1244 T1915 T1916 arg1Of ligases,(
R1245 T1915 T1919 arg1Of ligases,","
R1246 T1915 T1921 arg1Of ligases,as
R1247 T2008 T1975 arg1Of shown,On
R1248 T2008 T1979 arg1Of shown,","
R1249 T2008 T2006 arg2Of shown,have
R1250 T1915 T1931 arg1Of ligases,","
R1251 T2008 T2007 arg2Of shown,been
R1252 T1915 T1932 arg1Of ligases,[
R1253 T1915 T1936 arg1Of ligases,have
R1254 T2011 T2008 arg3Of regulate,shown
R1255 T2011 T2009 arg1Of regulate,to
R1256 T2011 T2010 arg1Of regulate,negatively
R1257 T2011 T2014 arg1Of regulate,by
R1258 T2013 T2011 arg2Of signaling,regulate
R1259 T2013 T2012 arg1Of signaling,RLR
R1260 T1915 T1937 arg1Of ligases,been
R1261 T1915 T1938 arg2Of ligases,shown
R1262 T1915 T1941 arg1Of ligases,promote
R1263 T2016 T2014 arg2Of removing,by
R1264 T2016 T2015 arg1Of removing,specifically
R1265 T2016 T2020 arg1Of removing,from
R1266 T1917 T1916 arg2Of E3s,(
R1267 T2019 T2016 arg2Of chains,removing
R1268 T2019 T2017 arg1Of chains,K63-linked
R1269 T2019 T2018 arg1Of chains,polyubiquitin
R1270 T1918 T1916 arg3Of ),(
R1271 T2023 T2020 arg2Of molecules,from
R1272 T2023 T2021 arg1Of molecules,several
R1273 T2023 T2022 arg1Of molecules,signaling
R1274 T1921 T1920 arg1Of as,such
R1275 T2029 T2026 arg1Of ligases,various
R1276 T2029 T2027 arg1Of ligases,K48-specific
R1277 T2029 T2028 arg1Of ligases,ubiquitin
R1278 T2029 T2030 arg1Of ligases,","
R1279 T2029 T2032 arg1Of ligases,as
R1280 T2029 T2051 arg1Of ligases,","
R1281 T2029 T2053 arg1Of ligases,inhibiting
R1282 T1922 T1923 arg1Of TRIM25,[
R1283 T2032 T2031 arg1Of as,such
R1284 T2033 T2034 arg1Of AIP4,[
R1285 T2033 T2037 arg1Of AIP4,and
R1286 T1922 T1926 arg1Of TRIM25,and
R1287 T1924 T1923 arg2Of 22,[
R1288 T2035 T2034 arg2Of 32,[
R1289 T2036 T2034 arg3Of ],[
R1290 T2037 T2032 arg2Of and,as
R1291 T1925 T1923 arg3Of ],[
R1292 T2040 T2039 arg2Of 33,[
R1293 T1926 T1921 arg2Of and,as
R1294 T2041 T2039 arg3Of ],[
R1295 T2042 T2038 arg1Of mark,TRIAD3A
R1296 T2042 T2039 arg1Of mark,[
R1297 T2042 T2043 arg1Of mark,respectively
R1298 T1927 T1926 arg2Of Riplet,and
R1299 T1927 T1928 arg1Of Riplet,[
R1300 T1929 T1928 arg2Of 23,[
R1301 T1930 T1928 arg3Of ],[
R1302 T2044 T2045 arg1Of MAVS,and
R1303 T2045 T2037 arg2Of and,and
R1304 T2045 T2042 arg1Of and,mark
R1305 T2045 T2047 arg1Of and,for
R1306 T1933 T1932 arg2Of 24,[
R1307 T2046 T2045 arg2Of TRAF3,and
R1308 T2050 T2047 arg2Of degradation,for
R1309 T2050 T2048 arg1Of degradation,proteasome
R1310 T2050 T2049 arg2Of degradation,mediated
R1311 T1934 T1932 arg3Of ],[
R1312 T2053 T2024 arg1Of inhibiting,Furthermore
R1313 T2053 T2025 arg1Of inhibiting,","
R1314 T2053 T2052 arg1Of inhibiting,thus
R1315 T1938 T1935 arg1Of shown,","
R1316 T2056 T2053 arg2Of signaling,inhibiting
R1317 T2056 T2054 arg1Of signaling,further
R1318 T2056 T2055 arg1Of signaling,downstream
R1319 T2060 T2059 arg1Of attachment,the
R1320 T2060 T2061 arg1Of attachment,of
R1321 T2060 T2065 arg1Of attachment,to
R1322 T2060 T2072 arg1Of attachment,by
R1323 T2060 T2091 arg1Of attachment,dampens
R1324 T1938 T1936 arg2Of shown,have
R1325 T2064 T2061 arg2Of chains,of
R1326 T2064 T2062 arg1Of chains,K48-specific
R1327 T2064 T2063 arg1Of chains,polyubiquitin
R1328 T1938 T1937 arg2Of shown,been
R1329 T2067 T2068 arg1Of IRF3,and
R1330 T1941 T1938 arg3Of promote,shown
R1331 T2069 T2068 arg2Of IRF7,and
R1332 T2071 T2065 arg2Of factors,to
R1333 T2071 T2066 arg1Of factors,the
R1334 T2071 T2067 arg1Of factors,IRF3
R1335 T2071 T2069 arg1Of factors,IRF7
R1336 T2071 T2070 arg1Of factors,transcription
R1337 T2073 T2072 arg2Of E3s,by
R1338 T2073 T2075 arg1Of E3s,as
R1339 T1941 T1939 arg1Of promote,to
R1340 T2075 T2074 arg1Of as,such
R1341 T1941 T1940 arg1Of promote,directly
R1342 T2076 T2077 arg1Of RAUL,[
R1343 T2076 T2080 arg1Of RAUL,","
R1344 T1943 T1941 arg2Of activation,promote
R1345 T2078 T2077 arg2Of 34,[
R1346 T2079 T2077 arg3Of ],[
R1347 T2080 T2085 arg1Of ",",and
R1348 T1943 T1942 arg1Of activation,RIG-I
R1349 T2081 T2080 arg2Of TRIM21,","
R1350 T2081 T2082 arg1Of TRIM21,[
R1351 T1945 T1944 arg2Of addition,In
R1352 T2083 T2082 arg2Of 35,[
R1353 T2084 T2082 arg3Of ],[
R1354 T2085 T2075 arg2Of and,as
R1355 T2142 T2141 arg2Of response,in
R1356 T2086 T2085 arg2Of RBCK1,and
R1357 T2086 T2087 arg1Of RBCK1,[
R1358 T2088 T2087 arg2Of 36,[
R1359 T2089 T2087 arg3Of ],[
R1360 T2091 T2057 arg1Of dampens,Additionally
R1361 T2091 T2058 arg1Of dampens,","
R1362 T2091 T2090 arg1Of dampens,further
R1363 T2142 T2143 arg1Of response,to
R1364 T2145 T2143 arg2Of receptors,to
R1365 T2094 T2091 arg2Of transduction,dampens
R1366 T2094 T2092 arg1Of transduction,antiviral
R1367 T2094 T2093 arg1Of transduction,signal
R1368 T2095 T2096 arg1Of A20,is
R1369 T2145 T2144 arg1Of receptors,multiple
R1370 T2099 T2096 arg2Of enzyme,is
R1371 T2099 T2097 arg1Of enzyme,an
R1372 T2099 T2098 arg1Of enzyme,ubiquitin-editing
R1373 T2099 T2100 arg1Of enzyme,belonging
R1374 T2100 T2101 arg1Of belonging,to
R1375 T2145 T2147 arg1Of receptors,as
R1376 T2104 T2101 arg2Of family,to
R1377 T2147 T2146 arg1Of as,such
R1378 T2104 T2102 arg1Of family,the
R1379 T2104 T2103 arg1Of family,OTU-domain
R1380 T2104 T2105 arg1Of family,of
R1381 T2106 T2105 arg2Of DUBs,of
R1382 T2149 T2148 arg1Of receptor,TNF
R1383 T2149 T2150 arg1Of receptor,I
R1384 T2152 T2151 arg2Of 37,[
R1385 T2109 T2111 arg1Of A20,harbors
R1386 T2111 T2107 arg1Of harbors,Interestingly
R1387 T2111 T2108 arg1Of harbors,","
R1388 T2111 T2110 arg1Of harbors,also
R1389 T2153 T2151 arg3Of ],[
R1390 T2154 T2149 arg1Of –,receptor
R1391 T2154 T2151 arg1Of –,[
R1392 T2154 T2155 arg1Of –,[
R1393 T2120 T2111 arg2Of activity,harbors
R1394 T2120 T2112 arg1Of activity,atypical
R1395 T2120 T2113 arg1Of activity,zinc
R1396 T2120 T2114 arg1Of activity,finger
R1397 T2120 T2115 arg1Of activity,dependent
R1398 T2120 T2116 arg1Of activity,K48-specific
R1399 T2120 T2117 arg1Of activity,E3
R1400 T2120 T2118 arg1Of activity,ubiquitin
R1401 T2120 T2119 arg1Of activity,ligase
R1402 T2154 T2158 arg1Of –,","
R1403 T2156 T2155 arg2Of 39,[
R1404 T2122 T2123 arg1Of catalytic,and
R1405 T2124 T2123 arg2Of noncatalytic,and
R1406 T2125 T2121 arg1Of mechanisms,Both
R1407 T2125 T2122 arg1Of mechanisms,catalytic
R1408 T2125 T2124 arg1Of mechanisms,noncatalytic
R1409 T2125 T2126 arg1Of mechanisms,were
R1410 T2125 T2128 arg2Of mechanisms,shown
R1411 T2125 T2130 arg1Of mechanisms,be
R1412 T2125 T2131 arg2Of mechanisms,involved
R1413 T2157 T2155 arg3Of ],[
R1414 T2128 T2126 arg2Of shown,were
R1415 T2128 T2127 arg1Of shown,previously
R1416 T2158 T2164 arg1Of ",",and
R1417 T2131 T2128 arg3Of involved,shown
R1418 T2131 T2129 arg1Of involved,to
R1419 T2131 T2130 arg2Of involved,be
R1420 T2131 T2132 arg1Of involved,in
R1421 T2131 T2141 arg1Of involved,in
R1422 T2159 T2158 arg2Of TLR4,","
R1423 T2135 T2132 arg2Of regulation,in
R1424 T2135 T2133 arg1Of regulation,the
R1425 T2135 T2134 arg1Of regulation,negative
R1426 T2135 T2136 arg1Of regulation,of
R1427 T2135 T2139 arg1Of regulation,by
R1428 T2138 T2136 arg2Of signaling,of
R1429 T2138 T2137 arg1Of signaling,proinflammatory
R1430 T2140 T2139 arg2Of A20,by
R1431 T2159 T2160 arg1Of TLR4,[
R1432 T2161 T2160 arg2Of 40,[
R1433 T2162 T2160 arg3Of ],[
R1434 T2164 T2147 arg2Of and,as
R1435 T2238 T2235 arg2Of response,on
R1436 T2238 T2236 arg1Of response,the
R1437 T2238 T2237 arg1Of response,inflammatory
R1438 T2164 T2163 arg1Of and,","
R1439 T2240 T2239 arg1Of relevance,The
R1440 T2240 T2241 arg1Of relevance,of
R1441 T2240 T2244 arg1Of relevance,for
R1442 T2240 T2247 arg1Of relevance,has
R1443 T2240 T2249 arg1Of relevance,been
R1444 T2240 T2250 arg2Of relevance,illustrated
R1445 T2165 T2164 arg2Of IL-1R,and
R1446 T2243 T2241 arg2Of findings,of
R1447 T2243 T2242 arg1Of findings,these
R1448 T2165 T2166 arg1Of IL-1R,[
R1449 T2246 T2244 arg2Of disease,for
R1450 T2246 T2245 arg1Of disease,human
R1451 T2167 T2166 arg2Of 41,[
R1452 T2168 T2166 arg3Of ],[
R1453 T2250 T2247 arg2Of illustrated,has
R1454 T2250 T2248 arg1Of illustrated,recently
R1455 T2250 T2249 arg2Of illustrated,been
R1456 T2250 T2251 arg1Of illustrated,through
R1457 T2171 T2169 arg1Of role,The
R1458 T2253 T2251 arg2Of identification,through
R1459 T2253 T2252 arg1Of identification,the
R1460 T2253 T2254 arg1Of identification,of
R1461 T2171 T2170 arg1Of role,anti-inflammatory
R1462 T2255 T2254 arg2Of polymorphisms,of
R1463 T2255 T2256 arg1Of polymorphisms,in
R1464 T2255 T2260 arg1Of polymorphisms,that
R1465 T2255 T2261 arg1Of polymorphisms,are
R1466 T2255 T2262 arg2Of polymorphisms,associated
R1467 T2171 T2172 arg1Of role,of
R1468 T2171 T2174 arg1Of role,is
R1469 T2171 T2176 arg2Of role,demonstrated
R1470 T2259 T2256 arg2Of locus,in
R1471 T2259 T2257 arg1Of locus,the
R1472 T2259 T2258 arg1Of locus,A20
R1473 T2173 T2172 arg2Of A20,of
R1474 T2262 T2261 arg2Of associated,are
R1475 T2262 T2263 arg1Of associated,with
R1476 T2266 T2264 arg1Of diseases,several
R1477 T2266 T2265 arg1Of diseases,autoimmune
R1478 T2266 T2267 arg1Of diseases,and
R1479 T2267 T2263 arg2Of and,with
R1480 T2176 T2174 arg2Of demonstrated,is
R1481 T2269 T2267 arg2Of inflammation,and
R1482 T2269 T2268 arg1Of inflammation,chronic
R1483 T2269 T2270 arg1Of inflammation,[
R1484 T2271 T2270 arg2Of 45,[
R1485 T2272 T2270 arg3Of ],[
R1486 T2273 T2275 arg1Of In,to
R1487 T2176 T2175 arg1Of demonstrated,clearly
R1488 T2274 T2273 arg2Of contrast,In
R1489 T2179 T2176 arg1Of fact,demonstrated
R1490 T2278 T2277 arg1Of established,well
R1491 T2179 T2177 arg2Of fact,by
R1492 T2279 T2273 arg3Of function,In
R1493 T2279 T2276 arg1Of function,its
R1494 T2279 T2278 arg1Of function,established
R1495 T2279 T2280 arg1Of function,in
R1496 T2179 T2178 arg1Of fact,the
R1497 T2282 T2280 arg2Of regulation,in
R1498 T2282 T2281 arg1Of regulation,the
R1499 T2282 T2283 arg1Of regulation,of
R1500 T2183 T2181 arg1Of mice,A20
R1501 T2285 T2283 arg2Of responses,of
R1502 T2285 T2284 arg1Of responses,proinflammatory
R1503 T2288 T2287 arg1Of role,the
R1504 T2288 T2289 arg1Of role,of
R1505 T2288 T2291 arg1Of role,in
R1506 T2288 T2298 arg1Of role,is
R1507 T2288 T2301 arg2Of role,described
R1508 T2288 T2303 arg2Of role,limited
R1509 T2290 T2289 arg2Of A20,of
R1510 T2183 T2182 arg1Of mice,deficient
R1511 T2183 T2184 arg1Of mice,die
R1512 T2184 T2179 arg2Of die,fact
R1513 T2293 T2291 arg2Of regulation,in
R1514 T2293 T2292 arg1Of regulation,the
R1515 T2293 T2294 arg1Of regulation,of
R1516 T2184 T2180 arg1Of die,that
R1517 T2297 T2294 arg2Of responses,of
R1518 T2297 T2295 arg1Of responses,antiviral
R1519 T2297 T2296 arg1Of responses,immune
R1520 T2184 T2185 arg1Of die,early
R1521 T2184 T2186 arg1Of die,after
R1522 T2300 T2299 arg1Of well,less
R1523 T2187 T2186 arg2Of birth,after
R1524 T2301 T2302 arg1Of described,and
R1525 T2302 T2273 arg1Of and,In
R1526 T2302 T2286 arg1Of and,","
R1527 T2302 T2298 arg2Of and,is
R1528 T2302 T2300 arg1Of and,well
R1529 T2303 T2302 arg2Of limited,and
R1530 T2303 T2304 arg1Of limited,to
R1531 T2306 T2304 arg2Of number,to
R1532 T2306 T2305 arg1Of number,a
R1533 T2306 T2307 arg1Of number,of
R1534 T2309 T2308 arg1Of vitro,in
R1535 T2310 T2307 arg2Of studies,of
R1536 T2310 T2309 arg1Of studies,vitro
R1537 T2310 T2311 arg1Of studies,using
R1538 T2311 T2319 arg1Of using,","
R1539 T2311 T2320 modOf using,indicating
R1540 T2187 T2188 arg1Of birth,due
R1541 T2312 T2313 arg1Of overexpression,or
R1542 T2313 T2311 arg2Of or,using
R1543 T2313 T2315 arg1Of or,in
R1544 T2188 T2189 arg1Of due,to
R1545 T2314 T2313 arg2Of silencing,or
R1546 T2192 T2190 arg1Of inflammation,severe
R1547 T2318 T2315 arg2Of lines,in
R1548 T2318 T2316 arg1Of lines,specific
R1549 T2318 T2317 arg1Of lines,cell
R1550 T2192 T2191 arg1Of inflammation,multi-organ
R1551 T2322 T2323 arg1Of A20,may
R1552 T2192 T2193 arg1Of inflammation,and
R1553 T2193 T2189 arg2Of and,to
R1554 T2322 T2324 arg1Of A20,regulate
R1555 T2194 T2193 arg2Of cachexia,and
R1556 T2324 T2320 arg2Of regulate,indicating
R1557 T2324 T2321 arg1Of regulate,that
R1558 T2324 T2323 arg2Of regulate,may
R1559 T2325 T2326 arg1Of RIG-I-,and
R1560 T2194 T2195 arg1Of cachexia,[
R1561 T2326 T2329 arg1Of and,to
R1562 T2326 T2331 arg1Of and,and
R1563 T2196 T2195 arg2Of 37,[
R1564 T2328 T2326 arg2Of signaling,and
R1565 T2328 T2327 arg1Of signaling,TLR3-induced
R1566 T2330 T2329 arg2Of NF-κB,to
R1567 T2331 T2324 arg2Of and,regulate
R1568 T2197 T2195 arg3Of ],[
R1569 T2199 T2198 arg1Of recently,More
R1570 T2334 T2333 arg2Of 49,[
R1571 T2202 T2201 arg1Of targeting,gene
R1572 T2335 T2333 arg3Of ],[
R1573 T2336 T2331 arg2Of –,and
R1574 T2336 T2332 arg1Of –,IRF-3
R1575 T2336 T2333 arg1Of –,[
R1576 T2336 T2337 arg1Of –,[
R1577 T2338 T2337 arg2Of 52,[
R1578 T2339 T2337 arg3Of ],[
R1579 T2202 T2203 arg1Of targeting,of
R1580 T2202 T2205 arg1Of targeting,in
R1581 T2202 T2209 arg1Of targeting,was
R1582 T2202 T2210 arg2Of targeting,shown
R1583 T2345 T2344 arg1Of vivo,in
R1584 T2202 T2212 arg1Of targeting,be
R1585 T2346 T2342 arg1Of role,the
R1586 T2346 T2343 arg1Of role,precise
R1587 T2346 T2345 arg1Of role,vivo
R1588 T2346 T2347 arg1Of role,of
R1589 T2346 T2349 arg1Of role,in
R1590 T2346 T2355 arg1Of role,remains
R1591 T2346 T2357 arg1Of role,be
R1592 T2346 T2358 arg2Of role,clarified
R1593 T2348 T2347 arg2Of A20,of
R1594 T2202 T2213 arg2Of targeting,associated
R1595 T2202 T2228 arg1Of targeting,illustrating
R1596 T2351 T2349 arg2Of response,in
R1597 T2351 T2350 arg1Of response,the
R1598 T2351 T2352 arg1Of response,to
R1599 T2204 T2203 arg2Of A20,of
R1600 T2354 T2352 arg2Of infection,to
R1601 T2354 T2353 arg1Of infection,viral
R1602 T2355 T2340 arg1Of remains,However
R1603 T2355 T2341 arg1Of remains,","
R1604 T2208 T2205 arg2Of types,in
R1605 T2358 T2355 arg2Of clarified,remains
R1606 T2358 T2356 arg1Of clarified,to
R1607 T2358 T2357 arg2Of clarified,be
R1608 T2208 T2206 arg1Of types,specific
R1609 T2208 T2207 arg1Of types,cell
R1610 T2210 T2199 arg1Of shown,recently
R1611 T2365 T2359 arg2Of mice,Using
R1612 T2365 T2360 arg1Of mice,myeloid
R1613 T2365 T2361 arg1Of mice,cell
R1614 T2365 T2362 arg1Of mice,specific
R1615 T2365 T2363 arg1Of mice,A20
R1616 T2365 T2364 arg1Of mice,knockout
R1617 T2365 T2366 arg1Of mice,(
R1618 T2365 T2369 arg1Of mice,that
R1619 T2365 T2370 arg1Of mice,were
R1620 T2365 T2372 arg2Of mice,generated
R1621 T2367 T2366 arg2Of A20myel-KO,(
R1622 T2368 T2366 arg3Of ),(
R1623 T2210 T2200 arg1Of shown,","
R1624 T2372 T2370 arg2Of generated,were
R1625 T2372 T2371 arg1Of generated,recently
R1626 T2372 T2373 arg1Of generated,in
R1627 T2375 T2376 arg1Of lab,and
R1628 T2210 T2209 arg2Of shown,was
R1629 T2210 T2226 arg1Of shown,","
R1630 T2377 T2376 arg2Of primary,and
R1631 T2210 T2228 modOf shown,illustrating
R1632 T2378 T2373 arg2Of cells,in
R1633 T2378 T2374 arg1Of cells,our
R1634 T2378 T2375 arg1Of cells,lab
R1635 T2378 T2377 arg1Of cells,primary
R1636 T2378 T2379 arg2Of cells,derived
R1637 T2379 T2380 arg1Of derived,of
R1638 T2213 T2210 arg3Of associated,shown
R1639 T2382 T2380 arg2Of mice,of
R1640 T2382 T2381 arg1Of mice,these
R1641 T2384 T2359 arg1Of we,Using
R1642 T2384 T2386 arg1Of we,provide
R1643 T2386 T2359 modOf provide,Using
R1644 T2386 T2383 arg1Of provide,","
R1645 T2386 T2385 arg1Of provide,here
R1646 T2387 T2386 arg2Of evidence,provide
R1647 T2213 T2211 arg1Of associated,to
R1648 T2213 T2212 arg2Of associated,be
R1649 T2213 T2214 arg1Of associated,with
R1650 T2389 T2390 arg1Of A20,is
R1651 T2390 T2387 arg2Of is,evidence
R1652 T2390 T2388 arg1Of is,that
R1653 T2215 T2216 arg1Of autoimmunity,and
R1654 T2394 T2390 arg2Of regulator,is
R1655 T2394 T2391 arg1Of regulator,a
R1656 T2394 T2392 arg1Of regulator,crucial
R1657 T2394 T2393 arg1Of regulator,negative
R1658 T2394 T2395 arg1Of regulator,of
R1659 T2216 T2214 arg2Of and,with
R1660 T2220 T2219 arg2Of 42,[
R1661 T2397 T2398 arg1Of proinflammatory,and
R1662 T2399 T2398 arg2Of antiviral,and
R1663 T2400 T2395 arg2Of signaling,of
R1664 T2400 T2396 arg1Of signaling,IAV-induced
R1665 T2400 T2397 arg1Of signaling,proinflammatory
R1666 T2400 T2399 arg1Of signaling,antiviral
R1667 T2400 T2401 arg1Of signaling,in
R1668 T2402 T2401 arg2Of macrophages,in
R1669 T2221 T2219 arg3Of ],[
R1670 T2222 T2216 arg2Of –,and
R1671 T2406 T2405 arg1Of mice,A20myel-KO
R1672 T2406 T2407 arg1Of mice,show
R1673 T2407 T2403 arg1Of show,Interestingly
R1674 T2407 T2404 arg1Of show,","
R1675 T2407 T2413 arg1Of show,in
R1676 T2407 T2419 arg1Of show,compared
R1677 T2409 T2408 arg2Of survival,enhanced
R1678 T2409 T2410 arg1Of survival,and
R1679 T2410 T2407 arg2Of and,show
R1680 T2222 T2217 arg1Of –,chronic
R1681 T2412 T2410 arg2Of morbidity,and
R1682 T2412 T2411 arg2Of morbidity,reduced
R1683 T2222 T2218 arg1Of –,inflammation
R1684 T2414 T2413 arg2Of response,in
R1685 T2414 T2415 arg1Of response,to
R1686 T2222 T2219 arg1Of –,[
R1687 T2222 T2223 arg1Of –,[
R1688 T2224 T2223 arg2Of 48,[
R1689 T2418 T2415 arg2Of infection,to
R1690 T2418 T2416 arg1Of infection,IAV
R1691 T2418 T2417 arg1Of infection,lung
R1692 T2420 T2419 arg2Of to,compared
R1693 T2225 T2223 arg3Of ],[
R1694 T2423 T2420 arg2Of mice,to
R1695 T2423 T2421 arg1Of mice,wild
R1696 T2423 T2422 arg1Of mice,type
R1697 T2424 T2425 arg1Of Protection,against
R1698 T2424 T2427 arg1Of Protection,in
R1699 T2424 T2430 arg1Of Protection,is
R1700 T2424 T2431 arg2Of Protection,associated
R1701 T2424 T2439 arg1Of Protection,augmented
R1702 T2424 T2453 arg1Of Protection,enhanced
R1703 T2426 T2425 arg2Of IAV,against
R1704 T2228 T2227 arg1Of illustrating,further
R1705 T2429 T2427 arg2Of mice,in
R1706 T2429 T2428 arg1Of mice,A20myel-KO
R1707 T2431 T2430 arg2Of associated,is
R1708 T2431 T2432 arg1Of associated,with
R1709 T2431 T2438 arg1Of associated,","
R1710 T2230 T2231 arg1Of A20,is
R1711 T2231 T2228 arg2Of is,illustrating
R1712 T2231 T2229 arg1Of is,that
R1713 T2234 T2231 arg2Of brake,is
R1714 T2434 T2433 arg2Of cytokine,increased
R1715 T2434 T2435 arg1Of cytokine,and
R1716 T2435 T2432 arg2Of and,with
R1717 T2234 T2232 arg1Of brake,an
R1718 T2437 T2435 arg2Of production,and
R1719 T2437 T2436 arg1Of production,chemokine
R1720 T2234 T2233 arg1Of brake,important
R1721 T2438 T2452 arg1Of ",",and
R1722 T2234 T2235 arg1Of brake,on
R1723 T2439 T2438 arg2Of augmented,","
R1725 T2440 T2439 arg2Of recruitment,augmented
R1726 T2440 T2441 arg1Of recruitment,of
R1727 T2444 T2441 arg2Of cells,of
R1728 T2444 T2442 arg1Of cells,innate
R1729 T2444 T2443 arg1Of cells,immune
R1730 T2444 T2446 arg1Of cells,as
R1731 T2446 T2445 arg1Of as,such
R1732 T2447 T2448 arg1Of neutophils,and
R1733 T2448 T2446 arg2Of and,as
R1734 T2450 T2448 arg2Of macrophages,and
R1735 T2450 T2449 arg1Of macrophages,alveolar
R1737 T2452 T2451 arg1Of and,","
R1738 T2453 T2452 arg2Of enhanced,and
R1740 T2455 T2453 arg2Of clearance,enhanced
R1742 T2455 T2454 arg1Of clearance,viral
R1745 T2457 T2456 arg1Of results,These
R1746 T2457 T2458 arg1Of results,suggest
R1748 T2460 T2467 arg1Of boosting,by
R1751 T2460 T2474 arg1Of boosting,might
R1752 T2460 T2475 arg1Of boosting,have
R1754 T2464 T2460 arg2Of response,boosting
R1755 T2464 T2461 arg1Of response,the
R1756 T2464 T2462 arg1Of response,innate
R1757 T2464 T2463 arg1Of response,immune
R1758 T2464 T2465 arg1Of response,to
R1759 T2466 T2465 arg2Of IAV,to
R1761 T2468 T2467 arg2Of targeting,by
R1763 T2470 T2468 arg2Of activity,targeting
R1764 T2470 T2469 arg1Of activity,A20
R1765 T2470 T2471 arg1Of activity,in
R1767 T2473 T2471 arg2Of cells,in
R1768 T2473 T2472 arg1Of cells,myeloid
R1769 T2475 T2458 arg2Of have,suggest
R1770 T2475 T2459 arg1Of have,that
R1771 T2475 T2474 arg2Of have,might
R1773 T2477 T2475 arg2Of potential,have
R1774 T2477 T2476 arg1Of potential,therapeutic
R3335 T5083 T5084 arg1Of A20,inhibits
R3336 T5086 T5085 arg1Of NF-κB,RIG-I-induced
R3337 T5086 T5087 arg1Of NF-κB,and
R3338 T5087 T5084 arg2Of and,inhibits
R3339 T5089 T5087 arg2Of activation,and
R3340 T5089 T5088 arg1Of activation,IRF3
R3341 T5091 T5090 arg1Of signaling,RIG-I
R3342 T5091 T5092 arg1Of signaling,induces
R3343 T5094 T5092 arg2Of activation,induces
R3344 T5094 T5093 arg1Of activation,the
R3345 T5094 T5095 arg1Of activation,of
R3346 T5096 T5097 arg1Of NF-κB,","
R3347 T5097 T5099 arg1Of ",",and
R3348 T5098 T5097 arg2Of IRF3,","
R3349 T5100 T5099 arg2Of IRF7,and
R3350 T5102 T5095 arg2Of factors,of
R3351 T5102 T5096 arg1Of factors,NF-κB
R3352 T5102 T5098 arg1Of factors,IRF3
R3353 T5102 T5100 arg1Of factors,IRF7
R3354 T5102 T5101 arg1Of factors,transcription
R3355 T5102 T5103 arg1Of factors,","
R3356 T5102 T5104 arg1Of factors,which
R3357 T5102 T5105 arg1Of factors,promote
R3358 T5107 T5105 arg2Of expression,promote
R3359 T5107 T5106 arg1Of expression,the
R3360 T5107 T5108 arg1Of expression,of
R3361 T5110 T5109 arg1Of cytokines,proinflammatory
R3362 T5110 T5111 arg1Of cytokines,and
R3363 T5111 T5108 arg2Of and,of
R3364 T5111 T5115 arg1Of and,that
R3365 T5111 T5116 arg1Of and,restrict
R3366 T5114 T5111 arg2Of IFNs,and
R3367 T5114 T5112 arg1Of IFNs,type
R3368 T5114 T5113 arg1Of IFNs,I
R3369 T5119 T5116 arg2Of propagation,restrict
R3370 T5119 T5117 arg1Of propagation,further
R3371 T5119 T5118 arg1Of propagation,viral
R3372 T5121 T5120 arg1Of studies,Previous
R3373 T5121 T5122 arg1Of studies,have
R3374 T5121 T5123 arg1Of studies,shown
R3375 T5123 T5122 arg2Of shown,have
R3376 T5126 T5125 arg1Of expressed,ectopically
R3377 T5127 T5126 arg1Of A20,expressed
R3378 T5127 T5129 arg1Of A20,regulates
R3379 T5129 T5123 arg2Of regulates,shown
R3380 T5129 T5124 arg1Of regulates,that
R3381 T5129 T5128 arg1Of regulates,negatively
R3382 T5129 T5134 arg1Of regulates,upon
R3383 T5129 T5137 arg1Of regulates,[
R3384 T5129 T5140 arg1Of regulates,–
R3385 T5129 T5141 arg1Of regulates,[
R3386 T5130 T5131 arg1Of NF-κB,and
R3387 T5132 T5131 arg2Of IRF3,and
R3388 T5133 T5129 arg2Of activation,regulates
R3389 T5133 T5130 arg1Of activation,NF-κB
R3390 T5133 T5132 arg1Of activation,IRF3
R3391 T5136 T5134 arg2Of stimulation,upon
R3392 T5136 T5135 arg1Of stimulation,RIG-I
R3393 T5138 T5137 arg2Of 50,[
R3394 T5139 T5137 arg3Of ],[
R3395 T5142 T5141 arg2Of 52,[
R3396 T5143 T5141 arg3Of ],[
R3397 T5146 T5147 arg1Of we,show
R3398 T5147 T5144 arg1Of show,Similarly
R3399 T5147 T5145 arg1Of show,","
R3405 T5154 T5147 arg2Of prevents,show
R3406 T5154 T5148 arg1Of prevents,that
R3441 T5186 T5185 arg2Of RIG-I,of
R3443 T5188 T5187 arg2Of RIG-I,[
R3462 T5210 T5208 arg2Of activation,inhibits
R3463 T5210 T5209 arg1Of activation,IRF7
R3464 T5212 T5211 arg2Of IRF3,Unlike
R3465 T5214 T5215 arg1Of IRF7,is
R3466 T5214 T5219 arg2Of IRF7,expressed
R3467 T5216 T5217 arg1Of not,or
R3468 T5218 T5217 arg2Of weakly,or
R3469 T5219 T5215 arg2Of expressed,is
R3470 T5219 T5216 arg1Of expressed,not
R3471 T5219 T5218 arg1Of expressed,weakly
R3472 T5219 T5220 arg1Of expressed,under
R3473 T5219 T5223 arg1Of expressed,and
R3474 T5222 T5220 arg2Of conditions,under
R3475 T5222 T5221 arg1Of conditions,naïve
R3476 T5223 T5211 arg1Of and,Unlike
R3477 T5223 T5213 arg1Of and,","
R3478 T5226 T5224 arg1Of levels,IRF7
R3479 T5226 T5225 arg1Of levels,protein
R3480 T5226 T5227 arg1Of levels,are
R3481 T5226 T5229 arg2Of levels,upregulated
R3482 T5229 T5223 arg2Of upregulated,and
R3483 T5229 T5227 arg2Of upregulated,are
R3484 T5229 T5228 arg1Of upregulated,rapidly
R3485 T5229 T5230 arg1Of upregulated,upon
R3486 T5229 T5237 arg1Of upregulated,","
R3487 T5229 T5238 arg1Of upregulated,[
R3488 T5233 T5230 arg2Of activation,upon
R3489 T5233 T5231 arg1Of activation,virus-induced
R3490 T5233 T5232 arg1Of activation,IRF3
R3491 T5233 T5234 arg1Of activation,[
R3492 T5235 T5234 arg2Of 54,[
R3493 T5236 T5234 arg3Of ],[
R3494 T5239 T5238 arg2Of 55,[
R3495 T5240 T5238 arg3Of ],[
R3496 T5242 T5241 arg1Of determine,To
R3497 T5244 T5242 arg2Of effect,determine
R3498 T5244 T5243 arg1Of effect,the
R3499 T5244 T5245 arg1Of effect,of
R3500 T5244 T5247 arg1Of effect,on
R3501 T5246 T5245 arg2Of A20,of
R3502 T5249 T5247 arg2Of activation,on
R3503 T5249 T5248 arg1Of activation,IRF7
R3504 T5251 T5253 arg1Of we,transfected
R3505 T5253 T5241 modOf transfected,To
R3506 T5253 T5250 arg1Of transfected,","
R3507 T5253 T5252 arg1Of transfected,therefore
R3508 T5253 T5261 arg1Of transfected,together
R3509 T5255 T5253 arg2Of amounts,transfected
R3510 T5255 T5254 arg1Of amounts,minor
R3511 T5255 T5256 arg1Of amounts,of
R3512 T5260 T5256 arg2Of plasmid,of
R3513 T5260 T5257 arg1Of plasmid,an
R3514 T5260 T5258 arg1Of plasmid,IRF7
R3515 T5260 T5259 arg1Of plasmid,expression
R3516 T5261 T5262 arg1Of together,with
R3517 T5263 T5262 arg2Of plasmids,with
R3518 T5263 T5264 arg1Of plasmids,encoding
R3519 T5265 T5266 arg1Of RIG-I,(
R3520 T5265 T5269 arg1Of RIG-I,","
R3521 T5267 T5266 arg2Of 2CARD,(
R3522 T5268 T5266 arg3Of ),(
R3523 T5269 T5271 arg1Of ",",and
R3524 T5270 T5269 arg2Of A20,","
R3525 T5271 T5264 arg2Of and,encoding
R3526 T5277 T5271 arg2Of construct,and
R3527 T5277 T5272 arg1Of construct,an
R3528 T5277 T5273 arg1Of construct,IRF7-specific
R3529 T5277 T5274 arg1Of construct,IFNα4
R3530 T5277 T5275 arg1Of construct,luciferase
R3531 T5277 T5276 arg1Of construct,reporter
R3532 T5278 T5279 arg1Of RIG-I,(
R3533 T5280 T5279 arg2Of 2CARD,(
R3534 T5281 T5279 arg3Of ),(
R3535 T5282 T5278 arg1Of expression,RIG-I
R3536 T5282 T5283 arg1Of expression,in
R3537 T5282 T5289 arg1Of expression,showed
R3538 T5285 T5283 arg2Of absence,in
R3539 T5285 T5284 arg1Of absence,the
R3540 T5285 T5286 arg1Of absence,of
R3541 T5288 T5286 arg2Of co-expression,of
R3542 T5288 T5287 arg1Of co-expression,IRF7
R3543 T5289 T5304 arg1Of showed,","
R3544 T5289 T5305 arg1Of showed,whereas
R3545 T5293 T5289 arg2Of activation,showed
R3546 T5293 T5290 arg1Of activation,negligible
R3547 T5293 T5291 arg1Of activation,IFNα4
R3548 T5293 T5292 arg1Of activation,promoter
R3549 T5293 T5294 arg1Of activation,(
R3550 T5296 T5294 arg2Of bar,(
R3551 T5296 T5295 arg1Of bar,grey
R3552 T5296 T5297 arg1Of bar,","
R3553 T5296 T5300 arg1Of bar,","
R3554 T5299 T5297 arg2Of 1A,","
R3555 T5299 T5298 arg1Of 1A,figure
R3556 T5302 T5300 arg2Of graph,","
R3557 T5302 T5301 arg1Of graph,right
R3558 T5303 T5294 arg3Of ),(
R3559 T5309 T5306 arg1Of expression,significant
R3560 T5309 T5307 arg1Of expression,reporter
R3561 T5309 T5308 arg1Of expression,gene
R3562 T5309 T5310 arg1Of expression,was
R3563 T5309 T5311 arg2Of expression,observed
R3564 T5311 T5305 arg2Of observed,whereas
R3565 T5311 T5310 arg2Of observed,was
R3566 T5311 T5312 arg1Of observed,in
R3567 T5314 T5312 arg2Of presence,in
R3568 T5314 T5313 arg1Of presence,the
R3569 T5314 T5315 arg1Of presence,of
R3570 T5316 T5315 arg2Of IRF7,of
R3571 T5317 T5318 arg1Of Similar,to
R3572 T5321 T5318 arg2Of effect,to
R3573 T5321 T5319 arg1Of effect,its
R3574 T5321 T5320 arg1Of effect,inhibitory
R3575 T5321 T5322 arg1Of effect,on
R3576 T5323 T5324 arg1Of NF-κB,and
R3577 T5325 T5324 arg2Of IRF3,and
R3578 T5326 T5322 arg2Of activation,on
R3579 T5326 T5323 arg1Of activation,NF-κB
R3580 T5326 T5325 arg1Of activation,IRF3
R3581 T5328 T5330 arg1Of A20,prevented
R3582 T5330 T5317 arg1Of prevented,Similar
R3583 T5330 T5327 arg1Of prevented,","
R3584 T5330 T5329 arg1Of prevented,also
R3585 T5333 T5330 arg2Of activation,prevented
R3586 T5333 T5331 arg1Of activation,RIG-I-induced
R3587 T5333 T5332 arg1Of activation,IRF7
R3588 T5333 T5334 arg1Of activation,(
R3589 T5336 T5334 arg2Of 1A,(
R3590 T5336 T5335 arg1Of 1A,figure
R3591 T5336 T5337 arg1Of 1A,","
R3592 T5339 T5337 arg2Of graph,","
R3593 T5339 T5338 arg1Of graph,right
R3594 T5340 T5334 arg3Of ),(
R3595 T5342 T5341 arg1Of results,These
R3596 T5342 T5343 arg1Of results,demonstrate
R3597 T5345 T5343 arg2Of potential,demonstrate
R3598 T5345 T5344 arg1Of potential,the
R3599 T5345 T5346 arg1Of potential,of
R3600 T5345 T5348 modOf potential,to
R3601 T5347 T5346 arg2Of A20,of
R3602 T5349 T5348 arg1Of inhibit,to
R3603 T5351 T5350 arg1Of NF-κB,RIG-I-induced
R3604 T5351 T5352 arg1Of NF-κB,and
R3605 T5352 T5349 arg2Of and,inhibit
R3606 T5354 T5352 arg2Of activation,and
R3607 T5354 T5353 arg1Of activation,IRF3/7
R3608 T5356 T5355 arg1Of study,To
R3609 T5358 T5356 arg2Of effect,study
R3610 T5358 T5357 arg1Of effect,the
R3611 T5358 T5359 arg1Of effect,of
R3612 T5358 T5363 arg1Of effect,on
R3613 T5358 T5366 arg1Of effect,in
R3614 T5361 T5360 arg1Of expressed,endogenously
R3615 T5362 T5359 arg2Of A20,of
R3616 T5362 T5361 arg1Of A20,expressed
R3617 T5365 T5363 arg2Of signaling,on
R3618 T5365 T5364 arg1Of signaling,RIG-I-induced
R3619 T5369 T5368 arg1Of immunological,more
R3620 T5371 T5366 arg2Of context,in
R3621 T5371 T5367 arg1Of context,a
R3622 T5371 T5369 arg1Of context,immunological
R3623 T5371 T5370 arg1Of context,relevant
R3624 T5373 T5356 arg1Of we,study
R3625 T5373 T5374 arg1Of we,performed
R3626 T5374 T5355 modOf performed,To
R3627 T5374 T5372 arg1Of performed,","
R3628 T5376 T5374 arg2Of experiments,performed
R3629 T5376 T5375 arg1Of experiments,further
R3630 T5376 T5377 arg1Of experiments,in
R3631 T5381 T5377 arg2Of macrophages,in
R3632 T5381 T5378 arg1Of macrophages,A20
R3633 T5381 T5379 arg1Of macrophages,deficient
R3634 T5381 T5380 arg1Of macrophages,primary
R3635 T5386 T5383 arg1Of mice,A20
R3636 T5386 T5384 arg1Of mice,full
R3637 T5386 T5385 arg1Of mice,knockout
R3638 T5386 T5387 arg1Of mice,die
R3639 T5387 T5382 arg2Of die,Since
R3640 T5387 T5388 arg1Of die,prematurely
R3641 T5387 T5389 arg1Of die,as
R3642 T5391 T5389 arg2Of result,as
R3643 T5391 T5390 arg1Of result,a
R3644 T5391 T5392 arg1Of result,of
R3645 T5395 T5392 arg2Of inflammation,of
R3646 T5395 T5393 arg1Of inflammation,severe
R3647 T5395 T5394 arg1Of inflammation,multi-organ
R3648 T5395 T5396 arg1Of inflammation,[
R3649 T5397 T5396 arg2Of 37,[
R3650 T5398 T5396 arg3Of ],[
R3651 T5400 T5401 arg1Of we,generated
R3652 T5401 T5382 arg1Of generated,Since
R3653 T5401 T5399 arg1Of generated,","
R3654 T5402 T5401 arg2Of mice,generated
R3655 T5402 T5403 arg1Of mice,carrying
R3656 T5407 T5403 arg2Of allele,carrying
R3657 T5407 T5404 arg1Of allele,a
R3658 T5407 T5405 arg1Of allele,conditional
R3659 T5407 T5406 arg1Of allele,A20
R3660 T5407 T5408 arg2Of allele,in
R3661 T5407 T5409 arg1Of allele,which
R3662 T5410 T5411 arg1Of exon,IV
R3663 T5410 T5412 arg1Of exon,and
R3664 T5412 T5415 arg1Of and,were
R3665 T5412 T5416 arg2Of and,flanked
R3666 T5413 T5412 arg2Of exon,and
R3667 T5413 T5414 arg1Of exon,V
R3668 T5416 T5408 arg1Of flanked,in
R3669 T5416 T5415 arg2Of flanked,were
R3670 T5416 T5417 arg1Of flanked,by
R3671 T5420 T5417 arg2Of sites,by
R3672 T5420 T5418 arg1Of sites,two
R3673 T5420 T5419 arg1Of sites,loxP
R3674 T5420 T5421 arg1Of sites,[
R3675 T5422 T5421 arg2Of 56,[
R3676 T5423 T5421 arg3Of ],[
R3678 T5424 T5448 arg1Of Crossing,allowed
R3679 T5426 T5424 arg2Of mice,Crossing
R3680 T5426 T5425 arg1Of mice,these
R3681 T5426 T5427 arg1Of mice,with
R3682 T5429 T5427 arg2Of mice,with
R3683 T5429 T5428 arg1Of mice,transgenic
R3684 T5429 T5430 arg1Of mice,expressing
R3685 T5430 T5433 arg1Of expressing,under
R3686 T5432 T5430 arg2Of recombinase,expressing
R3687 T5432 T5431 arg1Of recombinase,Cre
R3688 T5434 T5433 arg2Of control,under
R3689 T5434 T5435 arg1Of control,of
R3690 T5439 T5435 arg2Of promoter,of
R3691 T5439 T5436 arg1Of promoter,the
R3692 T5439 T5437 arg1Of promoter,lysozyme
R3693 T5439 T5438 arg1Of promoter,M
R3694 T5440 T5441 arg1Of leads,to
R3695 T5440 T5444 arg1Of leads,in
R3696 T5440 T5447 arg1Of leads,and
R3697 T5443 T5441 arg2Of deletion,to
R3698 T5443 T5442 arg1Of deletion,specific
R3699 T5446 T5444 arg2Of cells,in
R3700 T5446 T5445 arg1Of cells,myeloid
R3701 T5448 T5447 arg2Of allowed,and
R3702 T5449 T5448 arg2Of us,allowed
R3703 T5449 T5451 arg1Of us,generate
R3704 T5451 T5448 arg3Of generate,allowed
R3705 T5451 T5450 arg1Of generate,to
R3706 T5457 T5451 arg2Of mice,generate
R3707 T5457 T5452 arg1Of mice,myeloid
R3708 T5457 T5453 arg1Of mice,cell
R3709 T5457 T5454 arg1Of mice,specific
R3710 T5457 T5455 arg1Of mice,A20
R3711 T5457 T5456 arg1Of mice,knockout
R3712 T5457 T5458 arg1Of mice,[
R3713 T5459 T5458 arg2Of 48,[
R3714 T5460 T5458 arg3Of ],[
R3715 T5462 T5461 arg1Of stimulate,To
R3716 T5465 T5462 arg2Of receptor,stimulate
R3717 T5465 T5463 arg1Of receptor,the
R3718 T5465 T5464 arg1Of receptor,RIG-I
R3719 T5467 T5462 arg1Of we,stimulate
R3720 T5467 T5468 arg1Of we,transfected
R3721 T5468 T5461 modOf transfected,To
R3722 T5468 T5466 arg1Of transfected,","
R3723 T5470 T5469 arg1Of BMDM,A20myel-KO
R3724 T5470 T5471 arg1Of BMDM,and
R3725 T5471 T5468 arg2Of and,transfected
R3726 T5471 T5476 arg1Of and,with
R3727 T5475 T5471 arg2Of cells,and
R3728 T5475 T5472 arg1Of cells,wild
R3729 T5475 T5473 arg1Of cells,type
R3730 T5475 T5474 arg1Of cells,control
R3731 T5478 T5476 arg2Of amounts,with
R3732 T5478 T5477 arg1Of amounts,minimal
R3733 T5478 T5479 arg1Of amounts,of
R3734 T5484 T5483 arg2Of LMW,(
R3735 T5485 T5483 arg3Of ),(
R3736 T5486 T5479 arg2Of poly,of
R3737 T5486 T5480 arg1Of poly,low
R3738 T5486 T5481 arg1Of poly,molecular
R3739 T5486 T5482 arg1Of poly,weight
R3740 T5486 T5483 arg1Of poly,(
R3741 T5486 T5487 arg1Of poly,(
R3742 T5486 T5492 arg1Of poly,","
R3743 T5486 T5493 arg1Of poly,which
R3744 T5486 T5494 arg1Of poly,is
R3745 T5486 T5495 arg2Of poly,known
R3746 T5486 T5498 arg1Of poly,bind
R3747 T5486 T5500 arg1Of poly,activate
R3748 T5488 T5487 arg2Of I,(
R3749 T5488 T5489 arg1Of I,:
R3750 T5488 T5490 arg1Of I,C
R3751 T5491 T5487 arg3Of ),(
R3752 T5495 T5494 arg2Of known,is
R3753 T5498 T5499 arg1Of bind,and
R3754 T5499 T5495 arg3Of and,known
R3755 T5499 T5496 arg1Of and,to
R3756 T5499 T5497 arg1Of and,preferentially
R3757 T5499 T5505 arg1Of and,[
R3758 T5500 T5499 arg2Of activate,and
R3759 T5501 T5503 arg1Of RIG-I,than
R3760 T5503 T5498 arg2Of than,bind
R3761 T5503 T5500 arg2Of than,activate
R3762 T5503 T5502 arg1Of than,rather
R3763 T5504 T5503 arg2Of MDA5,than
R3764 T5506 T5505 arg2Of 57,[
R3765 T5507 T5505 arg3Of ],[
R3766 T5509 T5508 arg2Of note,Of
R3767 T5512 T5511 arg1Of concentration,this
R3768 T5512 T5513 arg1Of concentration,of
R3769 T5512 T5520 arg1Of concentration,was
R3770 T5512 T5521 arg1Of concentration,unable
R3771 T5512 T5523 arg1Of concentration,induce
R3772 T5514 T5513 arg2Of poly,of
R3773 T5514 T5515 arg1Of poly,(
R3774 T5516 T5515 arg2Of I,(
R3775 T5516 T5517 arg1Of I,:
R3776 T5516 T5518 arg1Of I,C
R3777 T5519 T5515 arg3Of ),(
R3778 T5520 T5508 arg1Of was,Of
R3779 T5520 T5510 arg1Of was,","
R3780 T5521 T5520 arg2Of unable,was
R3781 T5523 T5521 arg2Of induce,unable
R3782 T5523 T5522 arg1Of induce,to
R3783 T5526 T5524 arg1Of dependent,significant
R3784 T5526 T5525 arg1Of dependent,TLR3
R3785 T5527 T5528 arg1Of NF-κB,and
R3786 T5529 T5528 arg2Of IRF3,and
R3787 T5530 T5526 arg1Of activation,dependent
R3788 T5530 T5527 arg1Of activation,NF-κB
R3789 T5530 T5529 arg1Of activation,IRF3
R3790 T5530 T5531 arg1Of activation,or
R3791 T5531 T5523 arg2Of or,induce
R3792 T5533 T5531 arg2Of production,or
R3793 T5533 T5532 arg1Of production,cytokine
R3794 T5533 T5534 arg1Of production,(
R3795 T5535 T5534 arg2Of data,(
R3796 T5535 T5537 arg2Of data,shown
R3797 T5537 T5536 arg1Of shown,not
R3798 T5538 T5534 arg3Of ),(
R3799 T5540 T5539 arg2Of expected,As
R3800 T5544 T5543 arg2Of I,(
R3801 T5544 T5545 arg1Of I,:
R3802 T5544 T5546 arg1Of I,C
R3803 T5547 T5543 arg3Of ),(
R3804 T5548 T5542 arg1Of transfection,poly
R3805 T5548 T5543 arg1Of transfection,(
R3806 T5548 T5549 arg1Of transfection,induced
R3807 T5549 T5539 arg1Of induced,As
R3808 T5549 T5541 arg1Of induced,","
R3809 T5552 T5549 arg2Of expression,induced
R3810 T5552 T5550 arg1Of expression,the
R3811 T5552 T5551 arg1Of expression,rapid
R3812 T5552 T5553 arg1Of expression,of
R3813 T5554 T5553 arg2Of A20,of
R3814 T5554 T5555 arg1Of A20,in
R3815 T5554 T5561 arg1Of A20,in
R3816 T5555 T5559 arg1Of in,but
R3817 T5557 T5555 arg2Of type,in
R3818 T5557 T5556 arg1Of type,wild
R3819 T5559 T5558 arg1Of but,","
R3820 T5561 T5559 arg2Of in,but
R3821 T5561 T5560 arg1Of in,not
R3822 T5563 T5561 arg2Of BMDM,in
R3823 T5563 T5562 arg1Of BMDM,A20myel-KO
R3824 T5563 T5564 arg1Of BMDM,(
R3825 T5566 T5564 arg2Of 1B,(
R3826 T5566 T5565 arg1Of 1B,figure
R3827 T5566 T5567 arg1Of 1B,","
R3828 T5569 T5567 arg2Of panel,","
R3829 T5569 T5568 arg1Of panel,upper
R3830 T5570 T5564 arg3Of ),(
R3831 T5574 T5571 arg2Of points,At
R3832 T5574 T5572 arg1Of points,early
R3833 T5574 T5573 arg1Of points,time
R3834 T5579 T5576 arg1Of forms,slightly
R3835 T5579 T5577 arg1Of forms,slower
R3836 T5579 T5578 arg1Of forms,migrating
R3837 T5579 T5580 arg1Of forms,of
R3838 T5579 T5582 arg1Of forms,were
R3839 T5579 T5583 arg2Of forms,observed
R3840 T5581 T5580 arg2Of A20,of
R3841 T5583 T5571 arg1Of observed,At
R3842 T5583 T5575 arg1Of observed,","
R3843 T5583 T5582 arg2Of observed,were
R3844 T5583 T5584 arg1Of observed,","
R3845 T5583 T5585 modOf observed,indicating
R3846 T5587 T5588 arg1Of A20,undergoes
R3847 T5588 T5585 arg2Of undergoes,indicating
R3848 T5588 T5586 arg1Of undergoes,that
R3849 T5588 T5593 arg1Of undergoes,upon
R3850 T5591 T5590 arg1Of unknown,yet
R3851 T5592 T5588 arg2Of modification,undergoes
R3852 T5592 T5589 arg1Of modification,a
R3853 T5592 T5591 arg1Of modification,unknown
R3854 T5594 T5595 arg1Of poly,(
R3855 T5596 T5595 arg2Of I,(
R3856 T5596 T5597 arg1Of I,:
R3857 T5596 T5598 arg1Of I,C
R3858 T5599 T5595 arg3Of ),(
R3859 T5600 T5593 arg2Of transfection,upon
R3860 T5600 T5594 arg1Of transfection,poly
R3861 T5602 T5601 arg2Of to,Compared
R3862 T5605 T5602 arg2Of BMBM,to
R3863 T5605 T5603 arg1Of BMBM,wild
R3864 T5605 T5604 arg1Of BMBM,type
R3865 T5609 T5607 arg1Of cells,A20
R3866 T5609 T5608 arg1Of cells,deficient
R3867 T5609 T5610 arg1Of cells,showed
R3868 T5610 T5601 arg1Of showed,Compared
R3869 T5610 T5606 arg1Of showed,","
R3870 T5610 T5614 arg1Of showed,as
R3871 T5613 T5610 arg2Of activation,showed
R3872 T5613 T5611 arg2Of activation,enhanced
R3873 T5613 T5612 arg1Of activation,NF-κB
R3874 T5615 T5614 arg2Of indicated,as
R3875 T5618 T5617 arg2Of phosphorylation,increased
R3876 T5618 T5619 arg1Of phosphorylation,and
R3877 T5619 T5615 arg1Of and,indicated
R3878 T5619 T5616 arg2Of and,by
R3879 T5619 T5622 arg1Of and,of
R3880 T5621 T5619 arg2Of degradation,and
R3881 T5621 T5620 arg1Of degradation,sustained
R3882 T5623 T5622 arg2Of IκBα,of
R3883 T5623 T5624 arg1Of IκBα,(
R3884 T5626 T5624 arg2Of 1B,(
R3885 T5626 T5625 arg1Of 1B,figure
R3886 T5627 T5624 arg3Of ),(
R3887 T5631 T5630 arg1Of translocation,nuclear
R3888 T5631 T5632 arg1Of translocation,of
R3889 T5631 T5637 arg1Of translocation,was
R3890 T5631 T5638 arg2Of translocation,enhanced
R3891 T5636 T5632 arg2Of subunit,of
R3892 T5636 T5633 arg1Of subunit,the
R3893 T5636 T5634 arg1Of subunit,p65
R3894 T5636 T5635 arg1Of subunit,NF-κB
R3895 T5638 T5628 arg1Of enhanced,Furthermore
R3896 T5638 T5629 arg1Of enhanced,","
R3897 T5638 T5637 arg2Of enhanced,was
R3898 T5638 T5639 arg1Of enhanced,in
R3899 T5638 T5649 arg1Of enhanced,","
R3900 T5640 T5641 arg1Of poly,(
R3901 T5642 T5641 arg2Of I,(
R3902 T5642 T5643 arg1Of I,:
R3903 T5642 T5644 arg1Of I,C
R3904 T5645 T5641 arg3Of ),(
R3905 T5648 T5639 arg2Of BMDM,in
R3906 T5648 T5640 arg1Of BMDM,poly
R3907 T5648 T5646 arg2Of BMDM,transfected
R3908 T5648 T5647 arg1Of BMDM,A20myel-KO
R3909 T5650 T5638 arg3Of reaching,enhanced
R3910 T5650 T5653 arg1Of reaching,at
R3911 T5652 T5650 arg2Of maximum,reaching
R3912 T5652 T5651 arg1Of maximum,a
R3913 T5656 T5653 arg2Of points,at
R3914 T5656 T5654 arg1Of points,earlier
R3915 T5656 T5655 arg1Of points,time
R3916 T5656 T5657 arg2Of points,compared
R3917 T5657 T5658 arg1Of compared,to
R3918 T5661 T5658 arg2Of cells,to
R3919 T5661 T5659 arg1Of cells,wild
R3920 T5661 T5660 arg1Of cells,type
R3921 T5661 T5662 arg1Of cells,(
R3922 T5664 T5662 arg2Of 1C,(
R3923 T5664 T5663 arg1Of 1C,figure
R3924 T5665 T5662 arg3Of ),(
R3925 T5666 T5667 arg1Of IRF3,is
R3926 T5666 T5668 arg2Of IRF3,known
R3927 T5666 T5670 arg1Of IRF3,be
R3928 T5666 T5671 arg2Of IRF3,activated
R3929 T5668 T5667 arg2Of known,is
R3930 T5671 T5668 arg3Of activated,known
R3931 T5671 T5669 arg1Of activated,to
R3932 T5671 T5670 arg2Of activated,be
R3933 T5671 T5672 arg1Of activated,upon
R3934 T5671 T5692 arg1Of activated,","
R3935 T5671 T5693 modOf activated,leading
R3936 T5671 T5703 arg1Of activated,[
R3937 T5673 T5672 arg2Of phosphorylation,upon
R3938 T5673 T5674 arg1Of phosphorylation,of
R3939 T5676 T5674 arg2Of series,of
R3940 T5676 T5675 arg1Of series,a
R3941 T5676 T5677 arg1Of series,of
R3942 T5676 T5682 arg1Of series,by
R3943 T5681 T5677 arg2Of residues,of
R3944 T5681 T5678 arg1Of residues,carboxyl
R3945 T5681 T5679 arg1Of residues,terminal
R3946 T5681 T5680 arg1Of residues,serine
R3947 T5685 T5683 arg1Of kinases,the
R3948 T5685 T5684 arg1Of kinases,IKK-like
R3949 T5686 T5685 arg1Of TBK1,kinases
R3950 T5686 T5687 arg1Of TBK1,and
R3951 T5687 T5682 arg2Of and,by
R3952 T5688 T5687 arg2Of IKKε,and
R3953 T5688 T5689 arg1Of IKKε,[
R3954 T5690 T5689 arg2Of 58,[
R3955 T5691 T5689 arg3Of ],[
R3956 T5693 T5694 arg1Of leading,to
R3957 T5696 T5697 arg1Of dimerization,and
R3958 T5697 T5694 arg2Of and,to
R3959 T5697 T5695 arg1Of and,its
R3960 T5697 T5700 arg1Of and,to
R3961 T5699 T5697 arg2Of translocation,and
R3962 T5699 T5698 arg1Of translocation,subsequent
R3963 T5702 T5700 arg2Of nucleus,to
R3964 T5702 T5701 arg1Of nucleus,the
R3965 T5704 T5703 arg2Of 59,[
R3966 T5705 T5703 arg3Of ],[
R3967 T5707 T5706 arg2Of immunoblotting,Using
R3968 T5707 T5708 arg1Of immunoblotting,with
R3969 T5710 T5708 arg2Of antibody,with
R3970 T5710 T5709 arg1Of antibody,an
R3971 T5710 T5711 arg2Of antibody,directed
R3972 T5711 T5712 arg1Of directed,against
R3973 T5714 T5712 arg2Of Ser396,against
R3974 T5714 T5713 arg2Of Ser396,phosphorylated
R3975 T5718 T5706 arg1Of phosphorylation,Using
R3976 T5718 T5716 arg1Of phosphorylation,maximum
R3977 T5718 T5717 arg1Of phosphorylation,IRF3
R3978 T5718 T5719 arg1Of phosphorylation,was
R3979 T5718 T5720 arg2Of phosphorylation,detected
R3980 T5720 T5706 modOf detected,Using
R3981 T5720 T5715 arg1Of detected,","
R3982 T5720 T5719 arg2Of detected,was
R3983 T5720 T5721 arg1Of detected,at
R3984 T5720 T5728 arg1Of detected,compared
R3985 T5724 T5721 arg2Of points,at
R3986 T5724 T5722 arg1Of points,earlier
R3987 T5724 T5723 arg1Of points,time
R3988 T5724 T5725 arg1Of points,in
R3989 T5727 T5725 arg2Of BMDM,in
R3990 T5727 T5726 arg1Of BMDM,A20myel-KO
R3991 T5729 T5728 arg2Of to,compared
R3992 T5732 T5729 arg2Of BMDM,to
R3993 T5732 T5730 arg1Of BMDM,wild
R3994 T5732 T5731 arg1Of BMDM,type
R3995 T5732 T5733 arg1Of BMDM,(
R3996 T5735 T5733 arg2Of 1B,(
R3997 T5735 T5734 arg1Of 1B,figure
R3998 T5736 T5733 arg3Of ),(
R3999 T5737 T5738 arg1Of Similar,to
R4000 T5739 T5738 arg2Of p65,to
R4001 T5743 T5741 arg1Of translocation,IRF3
R4002 T5743 T5742 arg1Of translocation,nuclear
R4003 T5743 T5744 arg1Of translocation,reached
R4004 T5744 T5737 arg1Of reached,Similar
R4005 T5744 T5740 arg1Of reached,","
R4006 T5744 T5747 arg1Of reached,at
R4007 T5744 T5756 arg1Of reached,compared
R4008 T5746 T5744 arg2Of maximum,reached
R4009 T5746 T5745 arg1Of maximum,its
R4010 T5749 T5750 arg1Of earlier,time
R4011 T5751 T5747 arg2Of point,at
R4012 T5751 T5748 arg1Of point,an
R4013 T5751 T5749 arg1Of point,earlier
R4014 T5751 T5752 arg1Of point,in
R4015 T5755 T5752 arg2Of BMDM,in
R4016 T5755 T5753 arg1Of BMDM,A20
R4017 T5755 T5754 arg1Of BMDM,deficient
R4018 T5757 T5756 arg2Of to,compared
R4019 T5760 T5757 arg2Of cells,to
R4020 T5760 T5758 arg1Of cells,wild
R4021 T5760 T5759 arg1Of cells,type
R4022 T5760 T5761 arg1Of cells,(
R4023 T5763 T5761 arg2Of 1C,(
R4024 T5763 T5762 arg1Of 1C,figure
R4025 T5764 T5761 arg3Of ),(
R4026 T5765 T5766 arg1Of NF-κB,controls
R4027 T5766 T5774 arg1Of controls,and
R4028 T5768 T5766 arg2Of expression,controls
R4029 T5768 T5767 arg1Of expression,the
R4030 T5768 T5769 arg1Of expression,of
R4031 T5770 T5771 arg1Of IL-6,and
R4032 T5771 T5769 arg2Of and,of
R4033 T5772 T5771 arg2Of TNF,and
R4034 T5774 T5773 arg1Of and,","
R4035 T5775 T5776 arg1Of NF-κB,and
R4036 T5776 T5778 arg1Of and,control
R4037 T5777 T5776 arg2Of IRF3,and
R4038 T5778 T5774 arg2Of control,and
R4039 T5780 T5778 arg2Of expression,control
R4040 T5780 T5779 arg1Of expression,the
R4041 T5780 T5781 arg1Of expression,of
R4042 T5782 T5781 arg2Of IFNβ,of
R4043 T5784 T5783 arg2Of line,In
R4044 T5784 T5785 arg1Of line,with
R4045 T5788 T5785 arg2Of activation,with
R4046 T5788 T5786 arg1Of activation,the
R4047 T5788 T5787 arg2Of activation,enhanced
R4048 T5788 T5789 arg1Of activation,of
R4049 T5788 T5793 arg1Of activation,as
R4050 T5790 T5791 arg1Of NF-κB,and
R4051 T5791 T5789 arg2Of and,of
R4052 T5792 T5791 arg2Of IRF3,and
R4053 T5794 T5793 arg2Of described,as
R4054 T5794 T5795 arg1Of described,above
R4055 T5798 T5797 arg1Of BMDM,A20myel-KO
R4056 T5798 T5799 arg1Of BMDM,secreted
R4057 T5799 T5783 arg1Of secreted,In
R4058 T5799 T5796 arg1Of secreted,","
R4059 T5801 T5799 arg2Of amounts,secreted
R4060 T5801 T5800 arg2Of amounts,increased
R4061 T5801 T5802 arg1Of amounts,of
R4062 T5803 T5804 arg1Of IL-6,","
R4063 T5804 T5806 arg1Of ",",and
R4064 T5805 T5804 arg2Of TNF,","
R4065 T5806 T5802 arg2Of and,of
R4066 T5807 T5806 arg2Of IFNβ,and
R4067 T5807 T5808 arg1Of IFNβ,(
R4068 T5810 T5808 arg2Of 1D,(
R4069 T5810 T5809 arg1Of 1D,figure
R4070 T5811 T5808 arg3Of ),(
R4071 T5813 T5812 arg1Of results,Similar
R4072 T5813 T5814 arg1Of results,were
R4073 T5813 T5815 arg2Of results,obtained
R4074 T5815 T5814 arg2Of obtained,were
R4075 T5815 T5816 modOf obtained,using
R4076 T5818 T5816 arg2Of macrophages,using
R4077 T5818 T5817 arg1Of macrophages,peritoneal
R4078 T5818 T5819 arg1Of macrophages,(
R4079 T5820 T5819 arg2Of data,(
R4080 T5820 T5822 arg2Of data,shown
R4081 T5822 T5821 arg1Of shown,not
R4082 T5823 T5819 arg3Of ),(
R4083 T5827 T5826 arg1Of results,these
R4084 T5827 T5828 arg1Of results,demonstrate
R4085 T5828 T5824 arg1Of demonstrate,Together
R4086 T5828 T5825 arg1Of demonstrate,","
R4087 T5830 T5831 arg1Of A20,plays
R4088 T5831 T5828 arg2Of plays,demonstrate
R4089 T5831 T5829 arg1Of plays,that
R4090 T5831 T5835 arg1Of plays,in
R4091 T5834 T5831 arg2Of role,plays
R4092 T5834 T5832 arg1Of role,an
R4093 T5834 T5833 arg1Of role,important
R4094 T5838 T5835 arg2Of regulation,in
R4095 T5838 T5836 arg1Of regulation,the
R4096 T5838 T5837 arg1Of regulation,negative
R4097 T5838 T5839 arg1Of regulation,of
R4098 T5841 T5842 arg1Of NF-κB,and
R4099 T5843 T5842 arg2Of IRF3,and
R4100 T5844 T5839 arg2Of activation,of
R4101 T5844 T5840 arg1Of activation,RIG-I-induced
R4102 T5844 T5841 arg1Of activation,NF-κB
R4103 T5844 T5843 arg1Of activation,IRF3
R4104 T5844 T5845 arg1Of activation,in
R4105 T5847 T5845 arg2Of macrophages,in
R4106 T5847 T5846 arg1Of macrophages,primary
R5449 T7810 T7812 arg1Of A20,regulates
R5450 T7812 T7811 arg1Of regulates,negatively
R5451 T7815 T7812 arg2Of expression,regulates
R5452 T7815 T7813 arg1Of expression,IAV-induced
R5453 T7815 T7814 arg1Of expression,gene
R5454 T7815 T7816 arg1Of expression,in
R5455 T7817 T7816 arg2Of BMDM,in
R5456 T7819 T7818 arg1Of investigate,To
R5457 T7821 T7819 arg2Of role,investigate
R5458 T7821 T7820 arg1Of role,the
R5459 T7821 T7822 arg1Of role,of
R5460 T7821 T7824 arg1Of role,in
R5461 T7823 T7822 arg2Of A20,of
R5462 T7827 T7826 arg1Of proinflammatory,IAV-induced
R5463 T7827 T7828 arg1Of proinflammatory,and
R5464 T7831 T7828 arg2Of immune,and
R5465 T7831 T7829 arg1Of immune,antiviral
R5466 T7831 T7830 arg1Of immune,innate
R5467 T7832 T7824 arg2Of responses,in
R5468 T7832 T7825 arg1Of responses,the
R5469 T7832 T7827 arg1Of responses,proinflammatory
R5470 T7832 T7831 arg1Of responses,immune
R5471 T7834 T7819 arg1Of we,investigate
R5472 T7834 T7835 arg1Of we,infected
R5473 T7835 T7818 modOf infected,To
R5474 T7835 T7833 arg1Of infected,","
R5475 T7836 T7837 arg1Of A20,deficient
R5476 T7836 T7838 arg1Of A20,and
R5477 T7838 T7835 arg2Of and,infected
R5478 T7838 T7841 arg1Of and,with
R5479 T7840 T7838 arg2Of BMDM,and
R5480 T7840 T7839 arg1Of BMDM,control
R5481 T7843 T7841 arg2Of X-47,with
R5482 T7843 T7842 arg1Of X-47,IAV
R5483 T7843 T7844 arg1Of X-47,(
R5484 T7845 T7844 arg2Of H3N2,(
R5485 T7846 T7844 arg3Of ),(
R5486 T7849 T7847 arg1Of levels,A20
R5487 T7849 T7848 arg1Of levels,mRNA
R5488 T7849 T7850 arg1Of levels,were
R5489 T7849 T7852 arg2Of levels,induced
R5490 T7852 T7850 arg2Of induced,were
R5491 T7852 T7851 arg1Of induced,rapidly
R5492 T7852 T7853 arg1Of induced,in
R5493 T7852 T7860 arg1Of induced,in
R5494 T7852 T7864 arg1Of induced,","
R5495 T7852 T7865 arg1Of induced,upon
R5496 T7853 T7858 arg1Of in,but
R5497 T7856 T7853 arg2Of BMDM,in
R5498 T7856 T7854 arg1Of BMDM,wild
R5499 T7856 T7855 arg1Of BMDM,type
R5500 T7858 T7857 arg1Of but,","
R5501 T7860 T7858 arg2Of in,but
R5502 T7860 T7859 arg1Of in,not
R5503 T7863 T7860 arg2Of BMDM,in
R5504 T7863 T7861 arg1Of BMDM,A20
R5505 T7863 T7862 arg1Of BMDM,deficient
R5506 T7867 T7865 arg2Of infection,upon
R5507 T7867 T7866 arg1Of infection,viral
R5508 T7867 T7868 arg1Of infection,(
R5509 T7870 T7868 arg2Of 2A,(
R5510 T7870 T7869 arg1Of 2A,figure
R5511 T7871 T7868 arg3Of ),(
R5512 T7875 T7874 arg1Of BMDM,A20myel-KO
R5513 T7875 T7876 arg1Of BMDM,show
R5514 T7876 T7872 arg1Of show,Furthermore
R5515 T7876 T7873 arg1Of show,","
R5516 T7876 T7887 arg1Of show,compared
R5517 T7878 T7876 arg2Of expression,show
R5518 T7878 T7877 arg2Of expression,enhanced
R5519 T7878 T7879 arg1Of expression,of
R5520 T7878 T7884 arg1Of expression,after
R5521 T7880 T7881 arg1Of IL-6,and
R5522 T7882 T7881 arg2Of IFNβ,and
R5523 T7883 T7879 arg2Of mRNA,of
R5524 T7883 T7880 arg1Of mRNA,IL-6
R5525 T7883 T7882 arg1Of mRNA,IFNβ
R5526 T7886 T7884 arg2Of infection,after
R5527 T7886 T7885 arg1Of infection,IAV
R5528 T7888 T7887 arg2Of to,compared
R5529 T7890 T7888 arg2Of cells,to
R5530 T7890 T7889 arg1Of cells,control
R5531 T7890 T7891 arg1Of cells,(
R5532 T7893 T7891 arg2Of 2A,(
R5533 T7893 T7892 arg1Of 2A,figure
R5534 T7894 T7891 arg3Of ),(
R5535 T7896 T7895 arg2Of accordance,In
R5536 T7896 T7897 arg1Of accordance,with
R5537 T7899 T7897 arg2Of data,with
R5538 T7899 T7898 arg1Of data,these
R5539 T7903 T7901 arg1Of supernatant,cell
R5540 T7903 T7902 arg1Of supernatant,culture
R5541 T7903 T7904 arg2Of supernatant,collected
R5542 T7903 T7908 arg1Of supernatant,contained
R5543 T7904 T7905 arg1Of collected,from
R5544 T7907 T7905 arg2Of cells,from
R5545 T7907 T7906 arg1Of cells,these
R5546 T7908 T7895 arg1Of contained,In
R5547 T7908 T7900 arg1Of contained,","
R5548 T7910 T7908 arg2Of levels,contained
R5549 T7910 T7909 arg1Of levels,higher
R5550 T7910 T7911 arg1Of levels,of
R5551 T7912 T7913 arg1Of TNF,and
R5552 T7913 T7911 arg2Of and,of
R5553 T7913 T7915 arg1Of and,(
R5554 T7914 T7913 arg2Of IFNβ,and
R5555 T7917 T7915 arg2Of 2B,(
R5556 T7917 T7916 arg1Of 2B,figure
R5557 T7918 T7915 arg3Of ),(
R5558 T7921 T7919 arg2Of infection,Upon
R5559 T7921 T7920 arg1Of infection,host
R5560 T7921 T7922 arg1Of infection,with
R5561 T7923 T7922 arg2Of IAV,with
R5562 T7926 T7925 arg1Of macrophages,alveolar
R5563 T7926 T7927 arg1Of macrophages,are
R5564 T7926 T7936 arg1Of macrophages,attracting
R5565 T7927 T7919 arg1Of are,Upon
R5566 T7927 T7924 arg1Of are,","
R5567 T7927 T7935 arg1Of are,","
R5568 T7927 T7936 modOf are,attracting
R5569 T7930 T7927 arg2Of source,are
R5570 T7930 T7928 arg1Of source,an
R5571 T7930 T7929 arg1Of source,important
R5572 T7930 T7931 arg1Of source,of
R5573 T7932 T7933 arg1Of cytokines,and
R5574 T7933 T7931 arg2Of and,of
R5575 T7934 T7933 arg2Of chemokines,and
R5576 T7936 T7940 arg1Of attracting,to
R5577 T7936 T7943 arg1Of attracting,during
R5578 T7939 T7936 arg2Of cells,attracting
R5579 T7939 T7937 arg1Of cells,innate
R5580 T7939 T7938 arg1Of cells,immune
R5581 T7942 T7940 arg2Of lung,to
R5582 T7942 T7941 arg1Of lung,the
R5583 T7946 T7943 arg2Of phase,during
R5584 T7946 T7944 arg1Of phase,the
R5585 T7946 T7945 arg1Of phase,primary
R5586 T7946 T7947 arg1Of phase,of
R5587 T7948 T7947 arg2Of infection,of
R5588 T7950 T7949 arg1Of test,To
R5589 T7952 T7954 arg1Of A20,controls
R5590 T7954 T7950 arg2Of controls,test
R5591 T7954 T7951 arg1Of controls,whether
R5592 T7954 T7953 arg1Of controls,directly
R5593 T7957 T7954 arg2Of expression,controls
R5594 T7957 T7955 arg1Of expression,IAV-induced
R5595 T7957 T7956 arg1Of expression,gene
R5596 T7957 T7958 arg1Of expression,in
R5597 T7960 T7958 arg2Of macrophages,in
R5598 T7960 T7959 arg1Of macrophages,alveolar
R5599 T7962 T7950 arg1Of we,test
R5600 T7962 T7963 arg1Of we,isolated
R5601 T7962 T7974 arg1Of we,infected
R5602 T7963 T7973 arg1Of isolated,and
R5603 T7965 T7963 arg2Of cells,isolated
R5604 T7965 T7964 arg1Of cells,these
R5605 T7965 T7966 arg1Of cells,from
R5606 T7967 T7966 arg2Of lungs,from
R5607 T7967 T7968 arg1Of lungs,of
R5608 T7969 T7970 arg1Of A20myel-KO,and
R5609 T7971 T7970 arg2Of control,and
R5610 T7972 T7968 arg2Of littermates,of
R5611 T7972 T7969 arg1Of littermates,A20myel-KO
R5612 T7972 T7971 arg1Of littermates,control
R5613 T7973 T7949 modOf and,To
R5614 T7973 T7961 arg1Of and,","
R5615 T7974 T7973 arg2Of infected,and
R5616 T7974 T7977 arg1Of infected,vitro
R5617 T7974 T7978 arg1Of infected,with
R5618 T7975 T7974 arg2Of them,infected
R5619 T7977 T7976 arg1Of vitro,in
R5620 T7980 T7978 arg2Of X-47,with
R5621 T7980 T7979 arg1Of X-47,IAV
R5622 T7981 T7982 arg1Of Expression,and
R5623 T7982 T7984 arg1Of and,of
R5624 T7982 T8005 arg1Of and,and
R5625 T7983 T7982 arg2Of secretion,and
R5626 T7987 T7985 arg1Of cytokines,the
R5627 T7987 T7986 arg1Of cytokines,proinflammatory
R5628 T7988 T7989 arg1Of IL-6,and
R5629 T7989 T7984 arg2Of and,of
R5630 T7989 T7987 arg1Of and,cytokines
R5631 T7989 T7991 arg1Of and,","
R5632 T7990 T7989 arg2Of TNF,and
R5633 T7995 T7996 arg1Of IFNβ,and
R5634 T7996 T7992 arg1Of and,the
R5635 T7996 T7993 arg1Of and,type-I
R5636 T7996 T7994 arg1Of and,IFN
R5637 T7996 T7998 arg1Of and,and
R5638 T7997 T7996 arg2Of IFNα4,and
R5639 T7998 T7991 arg2Of and,","
R5640 T8001 T7998 arg2Of MCP-1,and
R5641 T8001 T7999 arg1Of MCP-1,the
R5642 T8001 T8000 arg1Of MCP-1,chemokines
R5643 T8001 T8002 arg1Of MCP-1,(
R5644 T8003 T8002 arg2Of ccl2,(
R5645 T8004 T8002 arg3Of ),(
R5646 T8005 T8010 arg1Of and,was
R5647 T8005 T8012 arg1Of and,higher
R5648 T8006 T8005 arg2Of KC,and
R5649 T8006 T8007 arg1Of KC,(
R5650 T8008 T8007 arg2Of cxcl1,(
R5651 T8009 T8007 arg3Of ),(
R5652 T8012 T8010 arg2Of higher,was
R5653 T8012 T8011 arg1Of higher,significantly
R5654 T8012 T8013 arg1Of higher,in
R5655 T8016 T8013 arg2Of cells,in
R5656 T8016 T8014 arg1Of cells,IAV
R5657 T8016 T8015 arg1Of cells,infected
R5658 T8016 T8017 arg1Of cells,lacking
R5659 T8017 T8019 arg1Of lacking,compared
R5660 T8018 T8017 arg2Of A20,lacking
R5661 T8020 T8019 arg2Of to,compared
R5662 T8024 T8020 arg2Of cells,to
R5663 T8024 T8021 arg1Of cells,infected
R5664 T8024 T8022 arg1Of cells,wild
R5665 T8024 T8023 arg1Of cells,type
R5666 T8024 T8025 arg1Of cells,(
R5667 T8027 T8026 arg1Of 2C,figure
R5668 T8027 T8028 arg1Of 2C,and
R5669 T8028 T8025 arg2Of and,(
R5670 T8030 T8028 arg2Of S1,and
R5671 T8030 T8029 arg1Of S1,figure
R5672 T8031 T8025 arg3Of ),(
R5673 T8032 T8033 arg1Of Taken,together
R5674 T8035 T8034 arg1Of results,these
R5675 T8035 T8036 arg1Of results,demonstrate
R5676 T8036 T8032 modOf demonstrate,Taken
R5677 T8038 T8040 arg1Of A20,regulates
R5678 T8040 T8036 arg2Of regulates,demonstrate
R5679 T8040 T8037 arg1Of regulates,that
R5680 T8040 T8039 arg1Of regulates,negatively
R5681 T8040 T8050 arg1Of regulates,","
R5682 T8040 T8051 arg1Of regulates,consistent
R5683 T8042 T8043 arg1Of proinflammatory,and
R5684 T8044 T8043 arg2Of antiviral,and
R5685 T8046 T8040 arg2Of expression,regulates
R5686 T8046 T8041 arg1Of expression,IAV-induced
R5687 T8046 T8042 arg1Of expression,proinflammatory
R5688 T8046 T8044 arg1Of expression,antiviral
R5689 T8046 T8045 arg1Of expression,gene
R5690 T8046 T8047 arg1Of expression,in
R5691 T8049 T8047 arg2Of macrophages,in
R5692 T8049 T8048 arg1Of macrophages,alveolar
R5693 T8051 T8052 arg1Of consistent,with
R5694 T8055 T8052 arg2Of effect,with
R5695 T8055 T8053 arg1Of effect,the
R5696 T8055 T8054 arg1Of effect,inhibitory
R5697 T8055 T8056 arg1Of effect,of
R5698 T8057 T8056 arg2Of A20,of
R5699 T8057 T8058 arg2Of A20,seen
R5700 T8058 T8059 arg1Of seen,on
R5701 T8061 T8060 arg1Of NF-κB,RIG-I-induced
R5702 T8061 T8062 arg1Of NF-κB,and
R5703 T8062 T8059 arg2Of and,on
R5704 T8064 T8062 arg2Of activation,and
R5705 T8064 T8063 arg1Of activation,IRF3
R6139 T8927 T8926 arg1Of deficiency,A20
R6140 T8927 T8928 arg1Of deficiency,in
R6141 T8927 T8931 arg1Of deficiency,protects
R6142 T8930 T8928 arg2Of cells,in
R6143 T8930 T8929 arg1Of cells,myeloid
R6144 T8931 T8932 arg1Of protects,against
R6145 T8935 T8932 arg2Of infection,against
R6146 T8935 T8933 arg1Of infection,IAV
R6147 T8935 T8934 arg1Of infection,lung
R6148 T8937 T8936 arg1Of determine,To
R6149 T8937 T8946 arg1Of determine,during
R6150 T8937 T8951 arg1Of determine,vivo
R6151 T8939 T8937 arg2Of role,determine
R6152 T8939 T8938 arg1Of role,the
R6153 T8939 T8940 arg1Of role,of
R6154 T8939 T8943 arg1Of role,in
R6155 T8942 T8940 arg2Of expression,of
R6156 T8942 T8941 arg1Of expression,A20
R6157 T8945 T8943 arg2Of cells,in
R6158 T8945 T8944 arg1Of cells,myeloid
R6159 T8949 T8946 arg2Of infection,during
R6160 T8949 T8947 arg1Of infection,an
R6161 T8949 T8948 arg1Of infection,IAV
R6162 T8951 T8950 arg1Of vivo,in
R6163 T8953 T8937 arg1Of we,determine
R6164 T8953 T8955 arg1Of we,inoculated
R6165 T8955 T8936 modOf inoculated,To
R6166 T8955 T8952 arg1Of inoculated,","
R6167 T8955 T8954 arg1Of inoculated,intranasally
R6168 T8955 T8979 arg1Of inoculated,in
R6169 T8958 T8957 arg1Of mice,A20myel-KO
R6170 T8958 T8959 arg1Of mice,and
R6171 T8959 T8955 arg2Of and,inoculated
R6172 T8959 T8956 arg1Of and,both
R6173 T8959 T8962 arg1Of and,with
R6174 T8959 T8969 arg2Of and,adapted
R6175 T8961 T8959 arg2Of littermates,and
R6176 T8961 T8960 arg1Of littermates,control
R6177 T8965 T8962 arg2Of dose,with
R6178 T8965 T8963 arg1Of dose,a
R6179 T8965 T8964 arg1Of dose,sublethal
R6180 T8965 T8966 arg1Of dose,of
R6181 T8968 T8966 arg2Of mouse,of
R6182 T8968 T8967 arg1Of mouse,the
R6183 T8973 T8972 arg2Of H3N2,(
R6184 T8974 T8972 arg3Of ),(
R6185 T8975 T8970 arg1Of strain,IAV
R6186 T8975 T8971 arg1Of strain,X-47
R6187 T8975 T8972 arg1Of strain,(
R6188 T8975 T8976 arg1Of strain,and
R6189 T8976 T8969 arg3Of and,adapted
R6190 T8978 T8976 arg2Of morbidity,and
R6191 T8978 T8977 arg2Of morbidity,monitored
R6192 T8980 T8979 arg2Of terms,in
R6193 T8980 T8981 arg1Of terms,of
R6194 T8983 T8981 arg2Of loss,of
R6195 T8983 T8982 arg1Of loss,weight
R6196 T8985 T8984 arg1Of mice,A20myel-KO
R6197 T8985 T8986 arg1Of mice,showed
R6198 T8985 T8997 arg1Of mice,recovered
R6199 T8986 T8990 arg1Of showed,compared
R6200 T8986 T8996 arg1Of showed,and
R6201 T8989 T8986 arg2Of loss,showed
R6202 T8989 T8987 arg2Of loss,reduced
R6203 T8989 T8988 arg1Of loss,weight
R6204 T8991 T8990 arg2Of to,compared
R6205 T8995 T8991 arg2Of littermates,to
R6206 T8995 T8992 arg1Of littermates,wild
R6207 T8995 T8993 arg1Of littermates,type
R6208 T8995 T8994 arg1Of littermates,control
R6209 T8997 T8996 arg2Of recovered,and
R6210 T8997 T8998 arg1Of recovered,faster
R6211 T8997 T8999 arg1Of recovered,from
R6212 T9002 T8999 arg2Of challenge,from
R6213 T9002 T9000 arg1Of challenge,the
R6214 T9002 T9001 arg1Of challenge,viral
R6215 T9002 T9003 arg1Of challenge,(
R6216 T9005 T9003 arg2Of 3A,(
R6217 T9005 T9004 arg1Of 3A,figure
R6218 T9006 T9003 arg3Of ),(
R6219 T9011 T9009 arg1Of concentration,total
R6220 T9011 T9010 arg1Of concentration,protein
R6221 T9011 T9012 arg1Of concentration,in
R6222 T9011 T9015 arg1Of concentration,","
R6223 T9011 T9016 arg1Of concentration,which
R6224 T9011 T9017 arg1Of concentration,reflects
R6225 T9011 T9024 arg1Of concentration,was
R6226 T9011 T9025 arg2Of concentration,increased
R6227 T9011 T9032 arg1Of concentration,post
R6228 T9011 T9043 arg1Of concentration,was
R6229 T9011 T9045 arg1Of concentration,lower
R6230 T9014 T9012 arg2Of fluid,in
R6231 T9014 T9013 arg1Of fluid,BAL
R6232 T9017 T9023 arg1Of reflects,","
R6233 T9019 T9018 arg1Of damage,lung
R6234 T9019 T9020 arg1Of damage,and
R6235 T9020 T9017 arg2Of and,reflects
R6236 T9022 T9020 arg2Of leakage,and
R6237 T9022 T9021 arg1Of leakage,vascular
R6238 T9025 T9023 arg2Of increased,","
R6239 T9025 T9024 arg2Of increased,was
R6240 T9025 T9026 arg1Of increased,significantly
R6241 T9025 T9027 arg1Of increased,at
R6242 T9028 T9029 arg1Of 7,and
R6243 T9030 T9029 arg2Of 10,and
R6244 T9031 T9027 arg2Of days,at
R6245 T9031 T9028 arg1Of days,7
R6246 T9031 T9030 arg1Of days,10
R6247 T9032 T9034 arg1Of post,in
R6248 T9032 T9042 arg1Of post,and
R6249 T9033 T9032 arg2Of infection,post
R6250 T9037 T9038 arg1Of type,and
R6251 T9039 T9038 arg2Of A20myel-KO,and
R6252 T9040 T9034 arg2Of mice,in
R6253 T9040 T9035 arg1Of mice,both
R6254 T9040 T9036 arg1Of mice,wild
R6255 T9040 T9037 arg1Of mice,type
R6256 T9040 T9039 arg1Of mice,A20myel-KO
R6257 T9042 T9007 arg1Of and,Also
R6258 T9042 T9008 arg1Of and,","
R6259 T9042 T9041 arg1Of and,","
R6260 T9043 T9042 arg2Of was,and
R6261 T9045 T9043 arg2Of lower,was
R6262 T9045 T9044 arg1Of lower,slightly
R6263 T9045 T9046 arg1Of lower,in
R6264 T9048 T9046 arg2Of mice,in
R6265 T9048 T9047 arg1Of mice,A20myel-KO
R6266 T9048 T9049 arg1Of mice,(
R6267 T9050 T9049 arg2Of data,(
R6268 T9050 T9052 arg2Of data,shown
R6269 T9052 T9051 arg1Of shown,not
R6270 T9053 T9049 arg3Of ),(
R6271 T9056 T9057 arg1Of we,measured
R6272 T9057 T9054 arg1Of measured,Next
R6273 T9057 T9055 arg1Of measured,","
R6274 T9057 T9061 arg1Of measured,at
R6275 T9060 T9057 arg2Of titers,measured
R6276 T9060 T9058 arg1Of titers,pulmonary
R6277 T9060 T9059 arg1Of titers,viral
R6278 T9062 T9063 arg1Of 4,","
R6279 T9063 T9065 arg1Of ",",and
R6280 T9064 T9063 arg2Of 7,","
R6281 T9066 T9065 arg2Of 10,and
R6282 T9069 T9061 arg2Of infection,at
R6283 T9069 T9062 arg1Of infection,4
R6284 T9069 T9064 arg1Of infection,7
R6285 T9069 T9066 arg1Of infection,10
R6286 T9069 T9067 arg1Of infection,days
R6287 T9069 T9068 arg1Of infection,post
R6288 T9071 T9070 arg1Of differences,No
R6289 T9071 T9072 arg1Of differences,in
R6290 T9071 T9075 arg1Of differences,were
R6291 T9071 T9076 arg2Of differences,observed
R6292 T9074 T9072 arg2Of titers,in
R6293 T9074 T9073 arg1Of titers,viral
R6294 T9076 T9075 arg2Of observed,were
R6295 T9076 T9077 arg1Of observed,in
R6296 T9076 T9080 arg1Of observed,versus
R6297 T9076 T9084 arg1Of observed,at
R6298 T9079 T9077 arg2Of mice,in
R6299 T9079 T9078 arg1Of mice,A20myel-KO
R6300 T9083 T9080 arg2Of mice,versus
R6301 T9083 T9081 arg1Of mice,wild
R6302 T9083 T9082 arg1Of mice,type
R6303 T9086 T9087 arg1Of 4,and
R6304 T9088 T9087 arg2Of 7,and
R6305 T9090 T9084 arg2Of infection,at
R6306 T9090 T9085 arg1Of infection,day
R6307 T9090 T9086 arg1Of infection,4
R6308 T9090 T9088 arg1Of infection,7
R6309 T9090 T9089 arg1Of infection,post
R6310 T9095 T9093 arg2Of days,after
R6311 T9095 T9094 arg1Of days,10
R6312 T9099 T9097 arg1Of virus,almost
R6313 T9099 T9098 arg1Of virus,no
R6314 T9099 T9100 arg1Of virus,could
R6315 T9099 T9101 arg1Of virus,be
R6316 T9099 T9102 arg2Of virus,detected
R6317 T9102 T9091 arg1Of detected,However
R6318 T9102 T9092 arg1Of detected,","
R6319 T9102 T9093 arg1Of detected,after
R6320 T9102 T9096 arg1Of detected,","
R6321 T9102 T9100 arg2Of detected,could
R6322 T9102 T9101 arg2Of detected,be
R6323 T9102 T9103 arg1Of detected,in
R6324 T9102 T9109 arg1Of detected,while
R6325 T9105 T9103 arg2Of lungs,in
R6326 T9105 T9104 arg1Of lungs,the
R6327 T9105 T9106 arg1Of lungs,of
R6328 T9108 T9106 arg2Of mice,of
R6329 T9108 T9107 arg1Of mice,A20myel-KO
R6330 T9113 T9110 arg1Of particles,abundant
R6331 T9113 T9111 arg1Of particles,infectious
R6332 T9113 T9112 arg1Of particles,viral
R6333 T9113 T9114 arg1Of particles,could
R6334 T9113 T9116 arg1Of particles,be
R6335 T9113 T9117 arg2Of particles,isolated
R6336 T9117 T9109 arg2Of isolated,while
R6337 T9117 T9114 arg2Of isolated,could
R6338 T9117 T9115 arg1Of isolated,still
R6339 T9117 T9116 arg2Of isolated,be
R6340 T9117 T9118 arg1Of isolated,from
R6341 T9119 T9118 arg2Of lungs,from
R6342 T9119 T9120 arg1Of lungs,of
R6343 T9124 T9120 arg2Of mice,of
R6344 T9124 T9121 arg1Of mice,all
R6345 T9124 T9122 arg1Of mice,wild
R6346 T9124 T9123 arg1Of mice,type
R6347 T9124 T9125 arg1Of mice,(
R6348 T9127 T9125 arg2Of 3B,(
R6349 T9127 T9126 arg1Of 3B,figure
R6350 T9128 T9125 arg3Of ),(
R6351 T9129 T9130 arg1Of This,indicates
R6352 T9132 T9133 arg1Of loss,of
R6353 T9132 T9135 arg1Of loss,in
R6354 T9132 T9138 arg1Of loss,does
R6355 T9132 T9140 arg1Of loss,affect
R6356 T9132 T9145 arg1Of loss,contributes
R6357 T9134 T9133 arg2Of A20,of
R6358 T9137 T9135 arg2Of cells,in
R6359 T9137 T9136 arg1Of cells,myeloid
R6360 T9140 T9138 arg2Of affect,does
R6361 T9140 T9139 arg1Of affect,not
R6362 T9140 T9144 arg1Of affect,but
R6363 T9143 T9140 arg2Of replication,affect
R6364 T9143 T9141 arg1Of replication,early
R6365 T9143 T9142 arg1Of replication,viral
R6366 T9144 T9130 arg2Of but,indicates
R6367 T9144 T9131 arg1Of but,that
R6368 T9145 T9144 arg2Of contributes,but
R6369 T9145 T9146 arg1Of contributes,to
R6370 T9145 T9149 arg1Of contributes,at
R6371 T9145 T9152 arg1Of contributes,during
R6372 T9148 T9146 arg2Of clearance,to
R6373 T9148 T9147 arg1Of clearance,viral
R6374 T9151 T9149 arg2Of stages,at
R6375 T9151 T9150 arg1Of stages,later
R6376 T9153 T9152 arg2Of infection,during
R6377 T9155 T9154 arg1Of verify,To
R6378 T9155 T9156 arg1Of verify,if
R6379 T9158 T9157 arg1Of deficiency,A20
R6380 T9158 T9159 arg1Of deficiency,in
R6381 T9158 T9162 arg1Of deficiency,affects
R6382 T9161 T9159 arg2Of cells,in
R6383 T9161 T9160 arg1Of cells,myeloid
R6384 T9162 T9156 arg2Of affects,if
R6385 T9165 T9162 arg2Of expression,affects
R6386 T9165 T9163 arg1Of expression,IAV-induced
R6387 T9165 T9164 arg1Of expression,gene
R6388 T9165 T9166 arg1Of expression,in
R6389 T9168 T9166 arg2Of lung,in
R6390 T9168 T9167 arg1Of lung,the
R6391 T9170 T9155 arg1Of we,verify
R6392 T9170 T9171 arg1Of we,analyzed
R6393 T9171 T9154 modOf analyzed,To
R6394 T9171 T9169 arg1Of analyzed,","
R6395 T9171 T9179 arg1Of analyzed,in
R6396 T9173 T9171 arg2Of levels,analyzed
R6397 T9173 T9172 arg1Of levels,the
R6398 T9173 T9174 arg1Of levels,of
R6399 T9176 T9175 arg1Of chemokines,several
R6400 T9176 T9177 arg1Of chemokines,and
R6401 T9177 T9174 arg2Of and,of
R6402 T9178 T9177 arg2Of cytokines,and
R6403 T9182 T9179 arg2Of lavage,in
R6404 T9182 T9180 arg1Of lavage,the
R6405 T9182 T9181 arg1Of lavage,bronchoalveolar
R6406 T9182 T9183 arg1Of lavage,(
R6407 T9182 T9186 arg1Of lavage,at
R6408 T9184 T9183 arg2Of BAL,(
R6409 T9185 T9183 arg3Of ),(
R6410 T9188 T9189 arg1Of 4,","
R6411 T9189 T9191 arg1Of ",",and
R6412 T9190 T9189 arg2Of 7,","
R6413 T9192 T9191 arg2Of day,and
R6414 T9192 T9193 arg1Of day,10
R6415 T9195 T9186 arg2Of infection,at
R6416 T9195 T9187 arg1Of infection,day
R6417 T9195 T9188 arg1Of infection,4
R6418 T9195 T9190 arg1Of infection,7
R6419 T9195 T9192 arg1Of infection,day
R6420 T9195 T9194 arg1Of infection,following
R6421 T9196 T9197 arg1Of Levels,of
R6422 T9196 T9207 arg1Of Levels,were
R6423 T9196 T9209 arg1Of Levels,higher
R6424 T9198 T9199 arg1Of KC,and
R6425 T9199 T9205 arg1Of and,as
R6426 T9201 T9199 arg2Of chemokines,and
R6427 T9201 T9200 arg1Of chemokines,MIP-2
R6428 T9205 T9197 arg2Of as,of
R6429 T9205 T9202 arg1Of as,","
R6430 T9205 T9203 arg1Of as,as
R6431 T9205 T9204 arg1Of as,well
R6432 T9206 T9205 arg2Of IL-6,as
R6433 T9207 T9210 arg1Of were,at
R6434 T9207 T9214 arg1Of were,in
R6435 T9207 T9221 arg1Of were,compared
R6436 T9209 T9207 arg2Of higher,were
R6437 T9209 T9208 arg1Of higher,significantly
R6438 T9213 T9210 arg2Of p.i.,at
R6439 T9213 T9211 arg1Of p.i.,day
R6440 T9213 T9212 arg1Of p.i.,7
R6441 T9215 T9214 arg2Of BAL,in
R6442 T9215 T9216 arg1Of BAL,from
R6443 T9220 T9216 arg2Of mice,from
R6444 T9220 T9217 arg1Of mice,IAV
R6445 T9220 T9218 arg1Of mice,infected
R6446 T9220 T9219 arg1Of mice,A20myel-KO
R6447 T9222 T9221 arg2Of to,compared
R6448 T9227 T9222 arg2Of mice,to
R6449 T9227 T9223 arg1Of mice,IAV
R6450 T9227 T9224 arg1Of mice,infected
R6451 T9227 T9225 arg1Of mice,wild
R6452 T9227 T9226 arg1Of mice,type
R6453 T9227 T9228 arg1Of mice,(
R6454 T9230 T9228 arg2Of 3C,(
R6455 T9230 T9229 arg1Of 3C,figure
R6456 T9231 T9228 arg3Of ),(
R6457 T9234 T9232 arg2Of observations,Unlike
R6458 T9234 T9233 arg1Of observations,our
R6459 T9234 T9235 arg1Of observations,with
R6460 T9240 T9235 arg2Of macrophages,with
R6461 T9240 T9236 arg1Of macrophages,in
R6462 T9240 T9237 arg1Of macrophages,vitro
R6463 T9240 T9238 arg2Of macrophages,stimulated
R6464 T9240 T9239 arg1Of macrophages,primary
R6465 T9241 T9242 arg1Of we,could
R6466 T9241 T9244 arg1Of we,detect
R6467 T9244 T9232 arg1Of detect,Unlike
R6468 T9244 T9242 arg2Of detect,could
R6469 T9244 T9243 arg1Of detect,not
R6470 T9247 T9244 arg2Of increase,detect
R6471 T9247 T9245 arg1Of increase,a
R6472 T9247 T9246 arg1Of increase,significant
R6473 T9247 T9248 arg1Of increase,in
R6474 T9247 T9253 arg1Of increase,in
R6475 T9249 T9250 arg1Of MCP-1,or
R6476 T9251 T9250 arg2Of IFNα,or
R6477 T9252 T9248 arg2Of production,in
R6478 T9252 T9249 arg1Of production,MCP-1
R6479 T9252 T9251 arg1Of production,IFNα
R6480 T9255 T9253 arg2Of lungs,in
R6481 T9255 T9254 arg1Of lungs,the
R6482 T9255 T9256 arg1Of lungs,of
R6483 T9258 T9256 arg2Of animals,of
R6484 T9258 T9257 arg1Of animals,A20myel-KO
R6485 T9258 T9259 arg1Of animals,(
R6486 T9261 T9259 arg2Of 3C,(
R6487 T9261 T9260 arg1Of 3C,figure
R6488 T9262 T9259 arg3Of ),(
R6489 T9263 T9264 arg1Of KC,is
R6490 T9263 T9271 arg1Of KC,serves
R6491 T9264 T9270 arg1Of is,and
R6492 T9267 T9264 arg2Of orthologue,is
R6493 T9267 T9265 arg1Of orthologue,the
R6494 T9267 T9266 arg1Of orthologue,murine
R6495 T9267 T9268 arg1Of orthologue,of
R6496 T9269 T9268 arg2Of IL-8,of
R6497 T9270 T9280 arg1Of and,","
R6498 T9270 T9281 arg1Of and,while
R6499 T9271 T9270 arg2Of serves,and
R6500 T9271 T9272 arg1Of serves,together
R6501 T9271 T9273 arg1Of serves,with
R6502 T9271 T9275 arg1Of serves,as
R6503 T9274 T9273 arg2Of MIP-2,with
R6504 T9277 T9275 arg2Of chemoattractant,as
R6505 T9277 T9276 arg1Of chemoattractant,a
R6506 T9277 T9278 arg1Of chemoattractant,for
R6507 T9279 T9278 arg2Of neutrophils,for
R6508 T9282 T9283 arg1Of MCP-1,is
R6509 T9282 T9285 arg2Of MCP-1,known
R6510 T9285 T9281 arg2Of known,while
R6511 T9285 T9283 arg2Of known,is
R6512 T9285 T9284 arg1Of known,mainly
R6513 T9285 T9286 arg1Of known,as
R6514 T9288 T9286 arg2Of chemoattractant,as
R6515 T9288 T9287 arg1Of chemoattractant,a
R6516 T9288 T9289 arg1Of chemoattractant,for
R6517 T9290 T9289 arg2Of monocytes,for
R6518 T9290 T9291 arg1Of monocytes,","
R6519 T9290 T9292 arg1Of monocytes,which
R6520 T9290 T9294 arg1Of monocytes,develop
R6521 T9290 T9298 arg1Of monocytes,entering
R6522 T9294 T9293 arg1Of develop,eventually
R6523 T9294 T9295 arg1Of develop,into
R6524 T9294 T9297 arg1Of develop,upon
R6525 T9296 T9295 arg2Of macrophages,into
R6526 T9298 T9297 arg2Of entering,upon
R6527 T9298 T9302 arg1Of entering,[
R6528 T9301 T9298 arg2Of lumen,entering
R6529 T9301 T9299 arg1Of lumen,the
R6530 T9301 T9300 arg1Of lumen,alveolar
R6531 T9303 T9302 arg2Of 60,[
R6532 T9304 T9302 arg3Of ],[
R6533 T9305 T9306 arg1Of Consistent,with
R6534 T9309 T9310 arg1Of KC,and
R6535 T9311 T9310 arg2Of MIP-2,and
R6536 T9312 T9306 arg2Of levels,with
R6537 T9312 T9307 arg1Of levels,the
R6538 T9312 T9308 arg1Of levels,higher
R6539 T9312 T9309 arg1Of levels,KC
R6540 T9312 T9311 arg1Of levels,MIP-2
R6541 T9312 T9313 arg1Of levels,in
R6542 T9315 T9313 arg2Of mice,in
R6543 T9315 T9314 arg1Of mice,A20myel-KO
R6544 T9318 T9317 arg1Of number,the
R6545 T9318 T9319 arg1Of number,of
R6546 T9318 T9337 arg1Of number,was
R6547 T9318 T9339 arg1Of number,higher
R6548 T9320 T9319 arg2Of neutrophils,of
R6549 T9320 T9321 arg1Of neutrophils,(
R6550 T9320 T9327 arg1Of neutrophils,that
R6551 T9320 T9328 arg1Of neutrophils,were
R6552 T9320 T9329 arg2Of neutrophils,recruited
R6553 T9325 T9321 arg2Of F4/80−,(
R6554 T9325 T9322 arg1Of F4/80−,CD11b+
R6555 T9325 T9323 arg1Of F4/80−,Ly6C+
R6556 T9325 T9324 arg1Of F4/80−,Ly6G+
R6557 T9326 T9321 arg3Of ),(
R6558 T9329 T9328 arg2Of recruited,were
R6559 T9329 T9330 arg1Of recruited,in
R6560 T9333 T9330 arg2Of spaces,in
R6561 T9333 T9331 arg1Of spaces,the
R6562 T9333 T9332 arg1Of spaces,bronchoalveolar
R6563 T9333 T9334 arg1Of spaces,upon
R6564 T9336 T9334 arg2Of infection,upon
R6565 T9336 T9335 arg1Of infection,IAV
R6566 T9337 T9305 arg1Of was,Consistent
R6567 T9337 T9316 arg1Of was,","
R6568 T9337 T9340 arg1Of was,throughout
R6569 T9337 T9342 arg1Of was,in
R6570 T9337 T9345 arg1Of was,compared
R6571 T9339 T9337 arg2Of higher,was
R6572 T9339 T9338 arg1Of higher,clearly
R6573 T9341 T9340 arg2Of infection,throughout
R6574 T9344 T9342 arg2Of mice,in
R6575 T9344 T9343 arg1Of mice,A20myel-KO
R6576 T9346 T9345 arg2Of to,compared
R6577 T9348 T9346 arg2Of animals,to
R6578 T9348 T9347 arg1Of animals,control
R6579 T9348 T9349 arg1Of animals,(
R6580 T9351 T9349 arg2Of 3D,(
R6581 T9351 T9350 arg1Of 3D,figure
R6582 T9352 T9349 arg3Of ),(
R6583 T9354 T9355 arg1Of we,could
R6584 T9354 T9356 arg1Of we,detect
R6585 T9356 T9353 arg2Of detect,Although
R6586 T9356 T9355 arg2Of detect,could
R6587 T9359 T9356 arg2Of increase,detect
R6588 T9359 T9357 arg1Of increase,a
R6589 T9359 T9358 arg1Of increase,significant
R6590 T9359 T9360 arg1Of increase,in
R6591 T9361 T9362 arg1Of monocyte,(
R6592 T9364 T9362 arg2Of Ly6C+,(
R6593 T9364 T9363 arg1Of Ly6C+,CD11b+
R6594 T9365 T9362 arg3Of ),(
R6595 T9366 T9360 arg2Of recruitment,in
R6596 T9366 T9361 arg1Of recruitment,monocyte
R6597 T9366 T9367 arg1Of recruitment,at
R6598 T9371 T9367 arg2Of infection,at
R6599 T9371 T9368 arg1Of infection,day
R6600 T9371 T9369 arg1Of infection,4
R6601 T9371 T9370 arg1Of infection,post
R6602 T9373 T9374 arg1Of this,was
R6603 T9373 T9376 arg1Of this,evident
R6604 T9374 T9353 arg1Of was,Although
R6605 T9374 T9372 arg1Of was,","
R6606 T9374 T9375 arg1Of was,not
R6607 T9374 T9377 arg1Of was,at
R6608 T9374 T9381 arg1Of was,after
R6609 T9376 T9374 arg2Of evident,was
R6610 T9380 T9377 arg2Of points,at
R6611 T9380 T9378 arg1Of points,later
R6612 T9380 T9379 arg1Of points,time
R6613 T9382 T9381 arg2Of infection,after
R6614 T9382 T9383 arg1Of infection,(
R6615 T9382 T9387 arg1Of infection,","
R6616 T9382 T9388 arg1Of infection,which
R6617 T9382 T9389 arg1Of infection,is
R6618 T9382 T9390 arg1Of infection,consistent
R6619 T9385 T9383 arg2Of 3D,(
R6620 T9385 T9384 arg1Of 3D,figure
R6621 T9386 T9383 arg3Of ),(
R6622 T9390 T9389 arg2Of consistent,is
R6623 T9390 T9391 arg1Of consistent,with
R6624 T9390 T9397 arg1Of consistent,in
R6625 T9394 T9391 arg2Of expression,with
R6626 T9394 T9392 arg1Of expression,the
R6627 T9394 T9393 arg1Of expression,equal
R6628 T9394 T9395 arg1Of expression,of
R6629 T9396 T9395 arg2Of MCP-1,of
R6630 T9399 T9397 arg2Of groups,in
R6631 T9399 T9398 arg1Of groups,both
R6632 T9399 T9400 arg1Of groups,of
R6633 T9401 T9400 arg2Of mice,of
R6634 T9403 T9402 arg1Of number,The
R6635 T9403 T9404 arg1Of number,of
R6636 T9403 T9414 arg1Of number,was
R6637 T9403 T9416 arg2Of number,elevated
R6638 T9403 T9421 arg1Of number,did
R6639 T9403 T9423 arg1Of number,differ
R6640 T9407 T9404 arg2Of macrophages,of
R6641 T9407 T9405 arg1Of macrophages,resident
R6642 T9407 T9406 arg1Of macrophages,alveolar
R6643 T9407 T9408 arg1Of macrophages,(
R6644 T9412 T9408 arg2Of CD11b−,(
R6645 T9412 T9409 arg1Of CD11b−,autofluorescent+
R6646 T9412 T9410 arg1Of CD11b−,CD11c+
R6647 T9412 T9411 arg1Of CD11b−,F4/80+
R6648 T9413 T9408 arg3Of ),(
R6649 T9416 T9414 arg2Of elevated,was
R6650 T9416 T9415 arg1Of elevated,also
R6651 T9416 T9417 arg1Of elevated,in
R6652 T9416 T9420 arg1Of elevated,but
R6653 T9419 T9417 arg2Of mice,in
R6654 T9419 T9418 arg1Of mice,A20myel-KO
R6655 T9423 T9420 arg2Of differ,but
R6656 T9423 T9421 arg2Of differ,did
R6657 T9423 T9422 arg1Of differ,not
R6658 T9423 T9424 arg1Of differ,significantly
R6659 T9423 T9425 arg1Of differ,between
R6660 T9427 T9428 arg1Of infected,or
R6661 T9429 T9428 arg2Of mock,or
R6662 T9431 T9425 arg2Of mice,between
R6663 T9431 T9426 arg1Of mice,IAV
R6664 T9431 T9427 arg1Of mice,infected
R6665 T9431 T9429 arg1Of mice,mock
R6666 T9431 T9430 arg1Of mice,infected
R6667 T9431 T9432 arg1Of mice,(
R6668 T9434 T9432 arg2Of 3D,(
R6669 T9434 T9433 arg1Of 3D,figure
R6670 T9435 T9432 arg3Of ),(
R6671 T9436 T9437 arg1Of Elimination,of
R6672 T9436 T9441 arg1Of Elimination,depends
R6673 T9440 T9437 arg2Of cells,of
R6674 T9440 T9438 arg1Of cells,IAV
R6675 T9440 T9439 arg1Of cells,infected
R6676 T9441 T9442 arg1Of depends,on
R6677 T9445 T9442 arg2Of expansion,on
R6678 T9445 T9443 arg1Of expansion,the
R6679 T9445 T9444 arg1Of expansion,clonal
R6680 T9445 T9446 arg1Of expansion,of
R6681 T9452 T9446 arg2Of cells,of
R6682 T9452 T9447 arg1Of cells,virus
R6683 T9452 T9448 arg1Of cells,specific
R6684 T9452 T9449 arg1Of cells,cytotoxic
R6685 T9452 T9450 arg1Of cells,CD8+
R6686 T9452 T9451 arg1Of cells,T
R6687 T9452 T9453 arg1Of cells,(
R6688 T9452 T9456 arg1Of cells,[
R6689 T9452 T9459 arg1Of cells,","
R6690 T9452 T9460 arg1Of cells,[
R6691 T9452 T9463 arg1Of cells,","
R6692 T9452 T9464 arg1Of cells,[
R6693 T9454 T9453 arg2Of CTL,(
R6694 T9455 T9453 arg3Of ),(
R6695 T9457 T9456 arg2Of 61,[
R6696 T9458 T9456 arg3Of ],[
R6697 T9461 T9460 arg2Of 62,[
R6698 T9462 T9460 arg3Of ],[
R6699 T9465 T9464 arg2Of 63,[
R6700 T9466 T9464 arg3Of ],[
R6701 T9468 T9467 arg1Of test,To
R6702 T9471 T9470 arg1Of expression,A20
R6703 T9471 T9472 arg1Of expression,in
R6704 T9471 T9475 arg1Of expression,regulates
R6705 T9474 T9472 arg2Of cells,in
R6706 T9474 T9473 arg1Of cells,myeloid
R6707 T9475 T9468 arg2Of regulates,test
R6708 T9475 T9469 arg1Of regulates,whether
R6709 T9479 T9475 arg2Of response,regulates
R6710 T9479 T9476 arg1Of response,the
R6711 T9479 T9477 arg1Of response,antiviral
R6712 T9479 T9478 arg1Of response,CTL
R6713 T9484 T9481 arg1Of cells,total
R6714 T9484 T9482 arg1Of cells,CD8+
R6715 T9484 T9483 arg1Of cells,T
R6716 T9484 T9485 arg1Of cells,and
R6717 T9485 T9468 arg1Of and,test
R6718 T9485 T9499 arg1Of and,were
R6719 T9485 T9500 arg2Of and,measured
R6720 T9489 T9486 arg1Of B,virus
R6721 T9489 T9487 arg1Of B,specific
R6722 T9489 T9488 arg1Of B,Granzyme
R6723 T9489 T9490 arg1Of B,(
R6724 T9489 T9493 arg1Of B,and
R6725 T9491 T9490 arg2Of GrB,(
R6726 T9492 T9490 arg3Of ),(
R6727 T9493 T9485 arg2Of and,and
R6728 T9494 T9493 arg2Of IFNγ,and
R6729 T9494 T9495 arg1Of IFNγ,expressing
R6730 T9498 T9495 arg2Of cells,expressing
R6731 T9498 T9496 arg1Of cells,CD8+
R6732 T9498 T9497 arg1Of cells,T
R6733 T9500 T9467 modOf measured,To
R6734 T9500 T9480 arg1Of measured,","
R6735 T9500 T9499 arg2Of measured,were
R6736 T9500 T9501 arg1Of measured,in
R6737 T9502 T9503 arg1Of BAL,and
R6738 T9504 T9503 arg2Of lung,and
R6739 T9505 T9501 arg2Of parenchyma,in
R6740 T9505 T9502 arg1Of parenchyma,BAL
R6741 T9505 T9504 arg1Of parenchyma,lung
R6742 T9505 T9506 arg1Of parenchyma,of
R6743 T9508 T9509 arg1Of type,and
R6744 T9510 T9509 arg2Of A20myel-KO,and
R6745 T9511 T9506 arg2Of mice,of
R6746 T9511 T9507 arg1Of mice,wild
R6747 T9511 T9508 arg1Of mice,type
R6748 T9511 T9510 arg1Of mice,A20myel-KO
R6749 T9514 T9512 arg1Of increase,A
R6750 T9514 T9513 arg1Of increase,clear
R6751 T9514 T9515 arg1Of increase,in
R6752 T9514 T9519 arg1Of increase,could
R6753 T9514 T9520 arg1Of increase,be
R6754 T9514 T9521 arg2Of increase,detected
R6755 T9518 T9515 arg2Of cells,in
R6756 T9518 T9516 arg1Of cells,CD8+
R6757 T9518 T9517 arg1Of cells,T
R6758 T9521 T9519 arg2Of detected,could
R6759 T9521 T9520 arg2Of detected,be
R6760 T9521 T9522 arg1Of detected,at
R6761 T9521 T9530 arg1Of detected,but
R6762 T9524 T9525 arg1Of 7,and
R6763 T9526 T9525 arg2Of 10,and
R6764 T9528 T9522 arg2Of infection,at
R6765 T9528 T9523 arg1Of infection,day
R6766 T9528 T9524 arg1Of infection,7
R6767 T9528 T9526 arg1Of infection,10
R6768 T9528 T9527 arg1Of infection,post
R6769 T9530 T9529 arg1Of but,","
R6770 T9532 T9531 arg1Of differences,no
R6771 T9532 T9533 arg1Of differences,were
R6772 T9532 T9534 arg2Of differences,observed
R6773 T9534 T9530 arg2Of observed,but
R6774 T9534 T9533 arg2Of observed,were
R6775 T9534 T9535 arg1Of observed,between
R6776 T9536 T9537 arg1Of A20myel-KO,and
R6777 T9537 T9535 arg2Of and,between
R6778 T9540 T9537 arg2Of mice,and
R6779 T9540 T9538 arg1Of mice,wild
R6780 T9540 T9539 arg1Of mice,type
R6781 T9540 T9541 arg1Of mice,(
R6782 T9543 T9542 arg1Of S2A,figure
R6783 T9543 T9544 arg1Of S2A,and
R6784 T9544 T9541 arg2Of and,(
R6785 T9546 T9544 arg2Of S2C,and
R6786 T9546 T9545 arg1Of S2C,figure
R6787 T9547 T9541 arg3Of ),(
R6788 T9551 T9550 arg1Of number,the
R6789 T9551 T9552 arg1Of number,of
R6790 T9551 T9568 arg1Of number,were
R6791 T9551 T9570 arg2Of number,altered
R6792 T9553 T9554 arg1Of GrB,and
R6793 T9555 T9554 arg2Of IFNγ,and
R6794 T9558 T9553 arg1Of cells,GrB
R6795 T9558 T9555 arg1Of cells,IFNγ
R6796 T9558 T9556 arg1Of cells,CD8+
R6797 T9558 T9557 arg1Of cells,T
R6798 T9558 T9561 arg1Of cells,as
R6799 T9561 T9552 arg2Of as,of
R6800 T9561 T9559 arg1Of as,as
R6801 T9561 T9560 arg1Of as,well
R6802 T9564 T9561 arg2Of levels,as
R6803 T9564 T9562 arg1Of levels,IFNγ
R6804 T9564 T9563 arg1Of levels,expression
R6805 T9564 T9565 arg1Of levels,in
R6806 T9567 T9565 arg2Of lungs,in
R6807 T9567 T9566 arg1Of lungs,the
R6808 T9570 T9548 arg1Of altered,Also
R6809 T9570 T9549 arg1Of altered,","
R6810 T9570 T9568 arg2Of altered,were
R6811 T9570 T9569 arg1Of altered,not
R6812 T9573 T9570 arg1Of absence,altered
R6813 T9573 T9571 arg2Of absence,by
R6814 T9573 T9572 arg1Of absence,the
R6815 T9573 T9574 arg1Of absence,of
R6816 T9573 T9576 arg1Of absence,in
R6817 T9575 T9574 arg2Of A20,of
R6818 T9578 T9576 arg2Of cells,in
R6819 T9578 T9577 arg1Of cells,myeloid
R6820 T9578 T9579 arg1Of cells,(
R6821 T9581 T9579 arg2Of S2A–C,(
R6822 T9581 T9580 arg1Of S2A–C,figure
R6823 T9582 T9579 arg3Of ),(
R6824 T9583 T9584 arg1Of Protection,against
R6825 T9583 T9587 arg1Of Protection,is
R6826 T9583 T9589 arg2Of Protection,provided
R6827 T9586 T9584 arg2Of infection,against
R6828 T9586 T9585 arg1Of infection,IAV
R6829 T9589 T9587 arg2Of provided,is
R6830 T9589 T9588 arg1Of provided,also
R6831 T9594 T9589 arg1Of response,provided
R6832 T9594 T9590 arg2Of response,by
R6833 T9594 T9591 arg1Of response,the
R6834 T9594 T9592 arg1Of response,humoral
R6835 T9594 T9593 arg1Of response,immune
R6836 T9596 T9595 arg1Of test,To
R6837 T9598 T9599 arg1Of loss,of
R6838 T9598 T9601 arg1Of loss,in
R6839 T9598 T9604 arg1Of loss,affects
R6840 T9600 T9599 arg2Of A20,of
R6841 T9603 T9601 arg2Of cells,in
R6842 T9603 T9602 arg1Of cells,myeloid
R6843 T9604 T9596 arg2Of affects,test
R6844 T9604 T9597 arg1Of affects,whether
R6845 T9608 T9604 arg2Of immunity,affects
R6846 T9608 T9605 arg1Of immunity,B
R6847 T9608 T9606 arg1Of immunity,cell
R6848 T9608 T9607 arg2Of immunity,mediated
R6849 T9610 T9596 arg1Of we,test
R6850 T9610 T9611 arg1Of we,determined
R6851 T9611 T9595 modOf determined,To
R6852 T9611 T9609 arg1Of determined,","
R6853 T9611 T9618 arg1Of determined,in
R6854 T9614 T9613 arg2Of HA,(
R6855 T9615 T9613 arg3Of ),(
R6856 T9617 T9611 arg2Of titers,determined
R6857 T9617 T9612 arg1Of titers,hemagglutinin
R6858 T9617 T9613 arg1Of titers,(
R6859 T9617 T9616 arg1Of titers,antibody
R6860 T9620 T9618 arg2Of serum,in
R6861 T9620 T9619 arg1Of serum,the
R6862 T9620 T9621 arg1Of serum,of
R6863 T9622 T9623 arg1Of A20myel-KO,and
R6864 T9624 T9623 arg2Of wild,and
R6865 T9626 T9621 arg2Of littermates,of
R6866 T9626 T9622 arg1Of littermates,A20myel-KO
R6867 T9626 T9624 arg1Of littermates,wild
R6868 T9626 T9625 arg1Of littermates,type
R6869 T9630 T9629 arg1Of differences,no
R6870 T9630 T9631 arg1Of differences,could
R6871 T9630 T9632 arg1Of differences,be
R6872 T9630 T9633 arg2Of differences,detected
R6873 T9633 T9627 arg1Of detected,However
R6874 T9633 T9628 arg1Of detected,","
R6875 T9633 T9631 arg2Of detected,could
R6876 T9633 T9632 arg2Of detected,be
R6877 T9633 T9634 arg1Of detected,between
R6878 T9633 T9644 arg1Of detected,","
R6879 T9633 T9645 modOf detected,indicating
R6880 T9636 T9635 arg1Of type,wild
R6881 T9636 T9637 arg1Of type,and
R6882 T9637 T9634 arg2Of and,between
R6883 T9639 T9637 arg2Of animals,and
R6884 T9639 T9638 arg1Of animals,A20myel-KO
R6885 T9639 T9640 arg1Of animals,(
R6886 T9642 T9640 arg2Of S2D,(
R6887 T9642 T9641 arg1Of S2D,figure
R6888 T9643 T9640 arg3Of ),(
R6889 T9648 T9647 arg1Of immunity,humoral
R6890 T9648 T9649 arg1Of immunity,is
R6891 T9648 T9651 arg2Of immunity,affected
R6892 T9651 T9645 arg2Of affected,indicating
R6893 T9651 T9646 arg1Of affected,that
R6894 T9651 T9649 arg2Of affected,is
R6895 T9651 T9650 arg1Of affected,not
R6896 T9654 T9651 arg1Of expression,affected
R6897 T9654 T9652 arg2Of expression,by
R6898 T9654 T9653 arg1Of expression,A20
R6899 T9654 T9655 arg1Of expression,in
R6900 T9657 T9655 arg2Of cells,in
R6901 T9657 T9656 arg1Of cells,myeloid
R6902 T9661 T9660 arg1Of data,these
R6903 T9661 T9662 arg1Of data,suggest
R6904 T9662 T9658 arg1Of suggest,Together
R6905 T9662 T9659 arg1Of suggest,","
R6906 T9664 T9665 arg1Of mechanisms,other
R6907 T9664 T9669 arg1Of mechanisms,","
R6908 T9664 T9671 arg1Of mechanisms,as
R6909 T9664 T9692 arg1Of mechanisms,contribute
R6910 T9665 T9666 arg1Of other,than
R6911 T9668 T9666 arg2Of immunity,than
R6912 T9668 T9667 arg1Of immunity,adaptive
R6913 T9671 T9670 arg1Of as,such
R6914 T9676 T9671 arg2Of response,as
R6915 T9676 T9672 arg1Of response,an
R6916 T9676 T9673 arg2Of response,increased
R6917 T9676 T9674 arg1Of response,innate
R6918 T9676 T9675 arg1Of response,immune
R6919 T9676 T9677 arg1Of response,","
R6920 T9676 T9678 arg2Of response,characterized
R6921 T9682 T9678 arg1Of influx,characterized
R6922 T9682 T9679 arg2Of influx,by
R6923 T9682 T9680 arg1Of influx,an
R6924 T9682 T9681 arg2Of influx,increased
R6925 T9682 T9683 arg1Of influx,of
R6926 T9682 T9688 arg1Of influx,of
R6927 T9684 T9685 arg1Of neutrophils,and
R6928 T9685 T9683 arg2Of and,of
R6929 T9687 T9685 arg2Of numbers,and
R6930 T9687 T9686 arg2Of numbers,increased
R6931 T9690 T9688 arg2Of macrophages,of
R6932 T9690 T9689 arg1Of macrophages,alveolar
R6933 T9692 T9662 arg2Of contribute,suggest
R6934 T9692 T9663 arg1Of contribute,that
R6935 T9692 T9691 arg1Of contribute,","
R6936 T9692 T9693 arg1Of contribute,to
R6937 T9697 T9693 arg2Of clearance,to
R6938 T9697 T9694 arg1Of clearance,the
R6939 T9697 T9695 arg1Of clearance,better
R6940 T9697 T9696 arg1Of clearance,viral
R6941 T9697 T9698 arg1Of clearance,in
R6942 T9700 T9698 arg2Of mice,in
R6943 T9700 T9699 arg1Of mice,A20myel-KO
R6944 T9701 T9702 arg1Of It,is
R6945 T9701 T9704 arg2Of It,believed
R6946 T9704 T9702 arg2Of believed,is
R6947 T9704 T9703 arg1Of believed,generally
R6948 T9707 T9706 arg1Of mortality,IAV-induced
R6949 T9707 T9708 arg1Of mortality,is
R6950 T9707 T9710 arg1Of mortality,to
R6951 T9708 T9704 arg3Of is,believed
R6952 T9708 T9705 arg1Of is,that
R6953 T9710 T9708 arg2Of to,is
R6954 T9710 T9709 arg1Of to,due
R6955 T9714 T9710 arg2Of response,to
R6956 T9714 T9711 arg1Of response,an
R6957 T9714 T9712 arg1Of response,excessive
R6958 T9714 T9713 arg1Of response,proinflammatory
R6959 T9714 T9715 arg1Of response,in
R6960 T9717 T9715 arg2Of lung,in
R6961 T9717 T9716 arg1Of lung,the
R6962 T9718 T9720 arg1Of We,analyzed
R6963 T9720 T9719 arg1Of analyzed,therefore
R6964 T9726 T9723 arg2Of production,increased
R6965 T9726 T9724 arg1Of production,proinflammatory
R6966 T9726 T9725 arg1Of production,cytokine
R6967 T9726 T9727 arg1Of production,and
R6968 T9727 T9722 arg1Of and,the
R6969 T9727 T9732 arg1Of and,in
R6970 T9727 T9735 arg1Of and,affects
R6971 T9728 T9727 arg2Of infiltration,and
R6972 T9728 T9729 arg1Of infiltration,of
R6973 T9731 T9729 arg2Of cells,of
R6974 T9731 T9730 arg1Of cells,proinflammatory
R6975 T9734 T9732 arg2Of mice,in
R6976 T9734 T9733 arg1Of mice,A20myel-KO
R6977 T9735 T9720 arg2Of affects,analyzed
R6978 T9735 T9721 arg1Of affects,whether
R6979 T9736 T9735 arg2Of mortality,affects
R6980 T9736 T9737 arg2Of mortality,induced
R6981 T9740 T9737 arg1Of infection,induced
R6982 T9740 T9738 arg2Of infection,by
R6983 T9740 T9739 arg1Of infection,intranasal
R6984 T9740 T9741 arg1Of infection,with
R6985 T9744 T9741 arg2Of dose,with
R6986 T9744 T9742 arg1Of dose,a
R6987 T9744 T9743 arg1Of dose,lethal
R6988 T9744 T9745 arg1Of dose,of
R6989 T9747 T9745 arg2Of X-47,of
R6990 T9747 T9746 arg1Of X-47,IAV
R6991 T9753 T9750 arg1Of mice,almost
R6992 T9753 T9751 arg1Of mice,all
R6993 T9753 T9752 arg1Of mice,A20myel-KO
R6994 T9753 T9754 arg1Of mice,survived
R6995 T9754 T9748 arg1Of survived,Surprisingly
R6996 T9754 T9749 arg1Of survived,","
R6997 T9754 T9755 arg1Of survived,(
R6998 T9754 T9758 arg1Of survived,","
R6999 T9754 T9759 arg1Of survived,while
R7000 T9756 T9755 arg2Of 10/11,(
R7001 T9757 T9755 arg3Of ),(
R7002 T9762 T9760 arg1Of mice,all
R7003 T9762 T9761 arg1Of mice,control
R7004 T9762 T9763 arg1Of mice,succumbed
R7005 T9763 T9759 arg2Of succumbed,while
R7006 T9763 T9764 arg1Of succumbed,(
R7007 T9763 T9767 arg1Of succumbed,within
R7008 T9763 T9770 arg1Of succumbed,after
R7009 T9765 T9764 arg2Of 0/11,(
R7010 T9766 T9764 arg3Of ),(
R7011 T9769 T9767 arg2Of days,within
R7012 T9769 T9768 arg1Of days,16
R7013 T9771 T9770 arg2Of infection,after
R7014 T9771 T9772 arg1Of infection,(
R7015 T9774 T9772 arg2Of 4A,(
R7016 T9774 T9773 arg1Of 4A,figure
R7017 T9775 T9772 arg3Of ),(
R7018 T9777 T9776 arg1Of mice,A20myel-KO
R7019 T9777 T9779 arg1Of mice,showed
R7020 T9777 T9808 arg1Of mice,were
R7021 T9777 T9809 arg1Of mice,able
R7022 T9777 T9811 arg1Of mice,recover
R7023 T9779 T9786 arg1Of showed,(
R7024 T9779 T9802 arg1Of showed,during
R7025 T9779 T9807 arg1Of showed,but
R7026 T9782 T9780 arg1Of loss,significant
R7027 T9782 T9781 arg1Of loss,weight
R7028 T9782 T9783 arg1Of loss,and
R7029 T9783 T9779 arg2Of and,showed
R7030 T9785 T9783 arg2Of damage,and
R7031 T9785 T9784 arg1Of damage,lung
R7032 T9787 T9786 arg2Of as,(
R7033 T9788 T9787 arg2Of reflected,as
R7034 T9793 T9788 arg1Of concentration,reflected
R7035 T9793 T9789 arg2Of concentration,by
R7036 T9793 T9790 arg2Of concentration,increased
R7037 T9793 T9791 arg1Of concentration,total
R7038 T9793 T9792 arg1Of concentration,protein
R7039 T9793 T9794 arg1Of concentration,in
R7040 T9796 T9797 arg1Of BAL,;
R7041 T9797 T9794 arg2Of ;,in
R7042 T9797 T9795 arg1Of ;,the
R7043 T9798 T9797 arg2Of data,;
R7044 T9798 T9800 arg2Of data,shown
R7045 T9800 T9799 arg1Of shown,not
R7046 T9801 T9786 arg3Of ),(
R7047 T9804 T9802 arg2Of course,during
R7048 T9804 T9803 arg1Of course,the
R7049 T9804 T9805 arg1Of course,of
R7050 T9806 T9805 arg2Of infection,of
R7051 T9807 T9778 arg1Of but,still
R7052 T9808 T9807 arg2Of were,but
R7053 T9808 T9812 arg1Of were,","
R7054 T9808 T9813 arg1Of were,in
R7055 T9809 T9808 arg2Of able,were
R7056 T9811 T9809 arg2Of recover,able
R7057 T9811 T9810 arg1Of recover,to
R7058 T9814 T9813 arg2Of contrast,in
R7059 T9814 T9815 arg1Of contrast,to
R7060 T9818 T9815 arg2Of mice,to
R7061 T9818 T9816 arg1Of mice,wild
R7062 T9818 T9817 arg1Of mice,type
R7063 T9818 T9819 arg1Of mice,that
R7064 T9818 T9820 arg1Of mice,succumbed
R7065 T9823 T9820 arg2Of 4B,succumbed
R7066 T9823 T9821 arg2Of 4B,(
R7067 T9823 T9822 arg1Of 4B,figure
R7068 T9824 T9821 arg3Of ),(
R7069 T9825 T9826 arg1Of Similar,to
R7070 T9828 T9826 arg2Of observations,to
R7071 T9828 T9827 arg1Of observations,our
R7072 T9828 T9829 arg1Of observations,with
R7073 T9832 T9829 arg2Of infection,with
R7074 T9832 T9830 arg1Of infection,sublethal
R7075 T9832 T9831 arg1Of infection,IAV
R7076 T9835 T9836 arg1Of KC,and
R7077 T9837 T9836 arg2Of MIP-2,and
R7078 T9838 T9834 arg1Of production,pulmonary
R7079 T9838 T9835 arg1Of production,KC
R7080 T9838 T9837 arg1Of production,MIP-2
R7081 T9838 T9839 arg1Of production,was
R7082 T9838 T9840 arg1Of production,stronger
R7083 T9839 T9825 arg1Of was,Similar
R7084 T9839 T9833 arg1Of was,","
R7085 T9839 T9849 arg1Of was,following
R7086 T9840 T9839 arg2Of stronger,was
R7087 T9840 T9841 arg1Of stronger,in
R7088 T9843 T9841 arg2Of animals,in
R7089 T9843 T9842 arg1Of animals,A20myel-KO
R7090 T9843 T9844 arg2Of animals,compared
R7091 T9844 T9845 arg1Of compared,to
R7092 T9848 T9845 arg2Of mice,to
R7093 T9848 T9846 arg1Of mice,wild
R7094 T9848 T9847 arg1Of mice,type
R7095 T9852 T9849 arg2Of infection,following
R7096 T9852 T9850 arg1Of infection,lethal
R7097 T9852 T9851 arg1Of infection,IAV
R7098 T9852 T9853 arg1Of infection,(
R7099 T9852 T9857 arg1Of infection,","
R7100 T9852 T9858 arg1Of infection,which
R7101 T9852 T9859 arg1Of infection,correlates
R7102 T9855 T9853 arg2Of 4C,(
R7103 T9855 T9854 arg1Of 4C,figure
R7104 T9856 T9853 arg3Of ),(
R7105 T9859 T9860 arg1Of correlates,with
R7106 T9863 T9860 arg2Of numbers,with
R7107 T9863 T9861 arg1Of numbers,the
R7108 T9863 T9862 arg2Of numbers,increased
R7109 T9863 T9864 arg1Of numbers,of
R7110 T9863 T9866 arg1Of numbers,in
R7111 T9865 T9864 arg2Of neutrophils,of
R7112 T9868 T9866 arg2Of lungs,in
R7113 T9868 T9867 arg1Of lungs,the
R7114 T9868 T9869 arg1Of lungs,of
R7115 T9871 T9869 arg2Of mice,of
R7116 T9871 T9870 arg1Of mice,these
R7117 T9871 T9872 arg1Of mice,(
R7118 T9874 T9872 arg2Of 4C,(
R7119 T9874 T9873 arg1Of 4C,figure
R7120 T9875 T9872 arg3Of ),(
R7121 T9877 T9878 arg1Of levels,of
R7122 T9877 T9887 arg1Of levels,","
R7123 T9877 T9888 arg1Of levels,which
R7124 T9877 T9889 arg1Of levels,are
R7125 T9877 T9891 arg2Of levels,associated
R7126 T9877 T9900 arg1Of levels,were
R7127 T9877 T9901 arg2Of levels,increased
R7128 T9881 T9879 arg1Of cytokines,the
R7129 T9881 T9880 arg1Of cytokines,proinflammatory
R7130 T9882 T9883 arg1Of IL-6,","
R7131 T9883 T9885 arg1Of ",",and
R7132 T9884 T9883 arg2Of TNF,","
R7133 T9885 T9878 arg2Of and,of
R7134 T9885 T9881 arg1Of and,cytokines
R7135 T9886 T9885 arg2Of IL-1β,and
R7136 T9891 T9889 arg2Of associated,are
R7137 T9891 T9890 arg1Of associated,often
R7138 T9891 T9892 arg1Of associated,with
R7139 T9893 T9892 arg2Of immunopathogenesis,with
R7140 T9893 T9894 arg1Of immunopathogenesis,in
R7141 T9895 T9894 arg2Of humans,in
R7142 T9895 T9896 arg1Of humans,[
R7143 T9897 T9896 arg2Of 64,[
R7144 T9898 T9896 arg3Of ],[
R7145 T9901 T9876 arg1Of increased,Also
R7146 T9901 T9899 arg1Of increased,","
R7147 T9901 T9900 arg2Of increased,were
R7148 T9901 T9902 arg1Of increased,in
R7149 T9901 T9908 arg1Of increased,compared
R7150 T9904 T9902 arg2Of lungs,in
R7151 T9904 T9903 arg1Of lungs,the
R7152 T9904 T9905 arg1Of lungs,of
R7153 T9907 T9905 arg2Of mice,of
R7154 T9907 T9906 arg1Of mice,A20myel-KO
R7155 T9909 T9908 arg2Of to,compared
R7156 T9911 T9909 arg2Of animals,to
R7157 T9911 T9910 arg1Of animals,control
R7158 T9911 T9912 arg1Of animals,(
R7159 T9914 T9913 arg1Of 4C,figure
R7160 T9914 T9915 arg1Of 4C,and
R7161 T9915 T9912 arg2Of and,(
R7162 T9917 T9915 arg2Of S3A,and
R7163 T9917 T9916 arg1Of S3A,figure
R7164 T9918 T9912 arg3Of ),(
R7165 T9922 T9921 arg1Of production,MCP-1
R7166 T9922 T9923 arg1Of production,was
R7167 T9922 T9925 arg2Of production,increased
R7168 T9922 T9928 arg1Of production,lower
R7169 T9925 T9919 arg1Of increased,Again
R7170 T9925 T9920 arg1Of increased,","
R7171 T9925 T9923 arg2Of increased,was
R7172 T9925 T9924 arg1Of increased,not
R7173 T9925 T9926 arg1Of increased,and
R7174 T9925 T9928 modOf increased,lower
R7175 T9925 T9937 arg1Of increased,and
R7176 T9928 T9927 arg1Of lower,even
R7177 T9928 T9929 arg1Of lower,in
R7178 T9931 T9929 arg2Of mice,in
R7179 T9931 T9930 arg1Of mice,A20myel-KO
R7180 T9931 T9932 arg1Of mice,(
R7181 T9934 T9932 arg2Of 4C,(
R7182 T9934 T9933 arg1Of 4C,figure
R7183 T9935 T9932 arg3Of ),(
R7184 T9937 T9936 arg1Of and,","
R7185 T9940 T9938 arg1Of recruitment,also
R7186 T9940 T9939 arg1Of recruitment,monocyte
R7187 T9940 T9941 arg1Of recruitment,was
R7188 T9940 T9943 arg1Of recruitment,different
R7189 T9941 T9937 arg2Of was,and
R7190 T9941 T9942 arg1Of was,not
R7191 T9943 T9941 arg2Of different,was
R7192 T9943 T9944 arg1Of different,between
R7193 T9946 T9944 arg2Of groups,between
R7194 T9946 T9945 arg1Of groups,both
R7195 T9946 T9947 arg1Of groups,of
R7196 T9948 T9947 arg2Of mice,of
R7197 T9949 T9950 arg1Of We,could
R7198 T9949 T9953 arg1Of We,detect
R7199 T9953 T9950 arg2Of detect,could
R7200 T9953 T9951 arg1Of detect,also
R7201 T9953 T9952 arg1Of detect,not
R7202 T9953 T9956 arg1Of detect,in
R7203 T9955 T9953 arg2Of differences,detect
R7204 T9955 T9954 arg1Of differences,any
R7205 T9958 T9957 arg1Of clearance,viral
R7206 T9958 T9959 arg1Of clearance,or
R7207 T9959 T9956 arg2Of or,in
R7208 T9959 T9963 arg1Of or,at
R7209 T9962 T9959 arg2Of immunity,or
R7210 T9962 T9960 arg1Of immunity,antiviral
R7211 T9962 T9961 arg1Of immunity,adaptive
R7212 T9967 T9963 arg2Of infection,at
R7213 T9967 T9964 arg1Of infection,6
R7214 T9967 T9965 arg1Of infection,h
R7215 T9967 T9966 arg1Of infection,post
R7216 T9967 T9968 arg1Of infection,(
R7217 T9970 T9968 arg2Of S3B–F,(
R7218 T9970 T9969 arg1Of S3B–F,figure
R7219 T9971 T9968 arg3Of ),(
R7220 T9974 T9973 arg1Of data,these
R7221 T9974 T9975 arg1Of data,indicate
R7222 T9975 T9972 arg1Of indicate,Collectively
R7223 T9978 T9977 arg1Of deficiency,A20
R7224 T9978 T9979 arg1Of deficiency,in
R7225 T9978 T9982 arg1Of deficiency,is
R7226 T9978 T9983 arg2Of deficiency,associated
R7227 T9981 T9979 arg2Of cells,in
R7228 T9981 T9980 arg1Of cells,myeloid
R7229 T9983 T9975 arg2Of associated,indicate
R7230 T9983 T9976 arg1Of associated,that
R7231 T9983 T9982 arg2Of associated,is
R7232 T9983 T9984 arg1Of associated,with
R7233 T9989 T9986 arg2Of response,increased
R7234 T9989 T9987 arg1Of response,innate
R7235 T9989 T9988 arg1Of response,immune
R7236 T9989 T9990 arg1Of response,and
R7237 T9990 T9984 arg2Of and,with
R7238 T9990 T9985 arg1Of and,an
R7239 T9990 T9992 arg1Of and,against
R7240 T9991 T9990 arg2Of protection,and
R7241 T9996 T9992 arg2Of infection,against
R7242 T9996 T9993 arg1Of infection,a
R7243 T9996 T9994 arg1Of infection,lethal
R7244 T9996 T9995 arg1Of infection,IAV
R8534 T12002 T12001 arg1Of study,present
R8535 T12003 T12004 arg1Of we,have
R8536 T12003 T12005 arg1Of we,investigated
R8538 T12005 T12004 arg2Of investigated,have
R8539 T12005 T12014 arg1Of investigated,in
R8540 T12007 T12005 arg2Of contribution,investigated
R8541 T12007 T12006 arg1Of contribution,the
R8542 T12007 T12008 arg1Of contribution,of
R8543 T12010 T12008 arg2Of expression,of
R8544 T12010 T12009 arg1Of expression,A20
R8545 T12010 T12011 arg1Of expression,in
R8546 T12013 T12011 arg2Of cells,in
R8547 T12013 T12012 arg1Of cells,myeloid
R8548 T12018 T12014 arg2Of response,in
R8549 T12018 T12015 arg1Of response,the
R8550 T12018 T12016 arg1Of response,innate
R8551 T12018 T12017 arg1Of response,immune
R8552 T12018 T12019 arg1Of response,to
R8553 T12022 T12019 arg2Of infection,to
R8554 T12022 T12020 arg1Of infection,IAV
R8555 T12022 T12021 arg1Of infection,lung
R8556 T12026 T12023 arg2Of environment,In
R8557 T12026 T12024 arg1Of environment,the
R8558 T12026 T12025 arg1Of environment,pulmonary
R8559 T12028 T12029 arg1Of macrophages,populate
R8560 T12029 T12023 arg1Of populate,In
R8561 T12029 T12027 arg1Of populate,","
R8562 T12032 T12030 arg1Of parenchyma,both
R8563 T12032 T12031 arg1Of parenchyma,lung
R8564 T12032 T12033 arg1Of parenchyma,and
R8565 T12033 T12029 arg2Of and,populate
R8566 T12036 T12033 arg2Of lumen,and
R8567 T12036 T12034 arg1Of lumen,the
R8568 T12036 T12035 arg1Of lumen,alveolar
R8569 T12036 T12037 arg1Of lumen,where
R8570 T12038 T12039 arg1Of they,are
R8571 T12038 T12040 arg2Of they,referred
R8572 T12040 T12037 arg2Of referred,where
R8573 T12040 T12039 arg2Of referred,are
R8574 T12040 T12041 arg1Of referred,to
R8575 T12040 T12042 arg1Of referred,as
R8576 T12044 T12042 arg2Of macrophages,as
R8577 T12044 T12043 arg1Of macrophages,alveolar
R8578 T12047 T12045 arg2Of conditions,Under
R8579 T12047 T12046 arg1Of conditions,naïve
R8580 T12050 T12049 arg1Of macrophages,alveolar
R8581 T12050 T12051 arg1Of macrophages,exert
R8582 T12051 T12045 arg1Of exert,Under
R8583 T12051 T12048 arg1Of exert,","
R8584 T12051 T12058 arg1Of exert,","
R8585 T12051 T12059 arg1Of exert,[
R8586 T12054 T12051 arg2Of functions,exert
R8587 T12054 T12052 arg1Of functions,important
R8588 T12054 T12053 arg1Of functions,immunomodulatory
R8589 T12054 T12055 arg1Of functions,[
R8590 T12056 T12055 arg2Of 65,[
R8591 T12057 T12055 arg3Of ],[
R8592 T12060 T12059 arg2Of 66,[
R8593 T12061 T12059 arg3Of ],[
R8594 T12065 T12064 arg1Of macrophages,alveolar
R8595 T12065 T12066 arg1Of macrophages,are
R8596 T12065 T12068 arg1Of macrophages,crucial
R8597 T12066 T12062 arg1Of are,However
R8598 T12066 T12063 arg1Of are,","
R8599 T12066 T12067 arg1Of are,also
R8600 T12066 T12069 arg1Of are,in
R8601 T12066 T12076 arg1Of are,as
R8602 T12068 T12066 arg2Of crucial,are
R8603 T12073 T12069 arg2Of response,in
R8604 T12073 T12070 arg1Of response,the
R8605 T12073 T12071 arg1Of response,innate
R8606 T12073 T12072 arg1Of response,immune
R8607 T12073 T12074 arg1Of response,against
R8608 T12075 T12074 arg2Of IAV,against
R8609 T12077 T12078 arg1Of they,are
R8610 T12078 T12076 arg2Of are,as
R8611 T12079 T12078 arg2Of one,are
R8612 T12079 T12080 arg1Of one,of
R8613 T12083 T12080 arg2Of cells,of
R8614 T12083 T12081 arg1Of cells,the
R8615 T12083 T12082 arg1Of cells,first
R8616 T12083 T12084 arg1Of cells,that
R8617 T12083 T12085 arg1Of cells,encounter
R8618 T12085 T12092 arg1Of encounter,","
R8619 T12085 T12093 arg1Of encounter,[
R8620 T12088 T12085 arg2Of particles,encounter
R8621 T12088 T12086 arg1Of particles,infectious
R8622 T12088 T12087 arg1Of particles,IAV
R8623 T12088 T12089 arg1Of particles,[
R8624 T12090 T12089 arg2Of 67,[
R8625 T12091 T12089 arg3Of ],[
R8626 T12094 T12093 arg2Of 68,[
R8627 T12095 T12093 arg3Of ],[
R8628 T12096 T12097 arg1Of They,are
R8629 T12097 T12124 arg1Of are,and
R8630 T12100 T12097 arg2Of source,are
R8631 T12100 T12098 arg1Of source,an
R8632 T12100 T12099 arg1Of source,important
R8633 T12100 T12101 arg1Of source,of
R8634 T12103 T12104 arg1Of cytokines,and
R8635 T12104 T12101 arg2Of and,of
R8636 T12104 T12102 arg1Of and,proinflammatory
R8637 T12104 T12106 arg1Of and,that
R8638 T12104 T12107 arg1Of and,attract
R8639 T12105 T12104 arg2Of chemokines,and
R8640 T12107 T12114 arg1Of attract,during
R8641 T12110 T12107 arg2Of cells,attract
R8642 T12110 T12108 arg1Of cells,innate
R8643 T12110 T12109 arg1Of cells,immune
R8644 T12110 T12111 arg1Of cells,to
R8645 T12113 T12111 arg2Of lung,to
R8646 T12113 T12112 arg1Of lung,the
R8647 T12117 T12114 arg2Of phase,during
R8648 T12117 T12115 arg1Of phase,the
R8649 T12117 T12116 arg1Of phase,primary
R8650 T12117 T12118 arg1Of phase,of
R8651 T12119 T12118 arg2Of infection,of
R8652 T12119 T12120 arg1Of infection,[
R8653 T12121 T12120 arg2Of 69,[
R8654 T12122 T12120 arg3Of ],[
R8655 T12124 T12123 arg1Of and,","
R8656 T12125 T12126 arg1Of they,are
R8657 T12126 T12124 arg2Of are,and
R8658 T12129 T12126 arg2Of producers,are
R8659 T12129 T12127 arg1Of producers,the
R8660 T12129 T12128 arg1Of producers,primary
R8661 T12129 T12130 arg1Of producers,of
R8662 T12133 T12130 arg2Of IFNs,of
R8663 T12133 T12131 arg1Of IFNs,type
R8664 T12133 T12132 arg1Of IFNs,I
R8665 T12133 T12134 arg1Of IFNs,[
R8666 T12135 T12134 arg2Of 70,[
R8667 T12136 T12134 arg3Of ],[
R8668 T12138 T12137 arg1Of macrophages,Alveolar
R8669 T12138 T12139 arg1Of macrophages,are
R8670 T12138 T12141 arg2Of macrophages,known
R8671 T12138 T12143 arg1Of macrophages,phagocytose
R8672 T12141 T12139 arg2Of known,are
R8673 T12141 T12140 arg1Of known,also
R8674 T12141 T12148 arg1Of known,and
R8675 T12143 T12141 arg3Of phagocytose,known
R8676 T12143 T12142 arg1Of phagocytose,to
R8677 T12147 T12143 arg2Of cells,phagocytose
R8678 T12147 T12144 arg1Of cells,virus
R8679 T12147 T12145 arg1Of cells,infected
R8680 T12147 T12146 arg1Of cells,apoptotic
R8681 T12149 T12150 arg1Of antibody,coated
R8682 T12149 T12155 arg1Of antibody,contributing
R8683 T12150 T12148 arg2Of coated,and
R8684 T12150 T12153 arg1Of coated,","
R8685 T12150 T12155 modOf coated,contributing
R8686 T12152 T12150 arg2Of particles,coated
R8687 T12152 T12151 arg1Of particles,viral
R8688 T12155 T12154 arg1Of contributing,further
R8689 T12155 T12156 arg1Of contributing,to
R8690 T12158 T12156 arg2Of clearance,to
R8691 T12158 T12157 arg1Of clearance,viral
R8692 T12159 T12160 arg1Of We,could
R8693 T12159 T12161 arg1Of We,show
R8694 T12161 T12160 arg2Of show,could
R8695 T12163 T12164 arg1Of BMDM,or
R8696 T12165 T12164 arg2Of alveolar,or
R8697 T12166 T12163 arg1Of macrophages,BMDM
R8698 T12166 T12165 arg1Of macrophages,alveolar
R8699 T12166 T12167 arg2Of macrophages,derived
R8700 T12166 T12171 arg1Of macrophages,express
R8701 T12167 T12168 arg1Of derived,from
R8702 T12170 T12168 arg2Of mice,from
R8703 T12170 T12169 arg1Of mice,A20myel-KO
R8704 T12171 T12161 arg2Of express,show
R8705 T12171 T12162 arg1Of express,that
R8706 T12171 T12182 arg1Of express,compared
R8707 T12171 T12187 arg1Of express,in
R8708 T12173 T12171 arg2Of amounts,express
R8709 T12173 T12172 arg1Of amounts,higher
R8710 T12173 T12174 arg1Of amounts,of
R8711 T12175 T12176 arg1Of chemokines,","
R8712 T12176 T12178 arg1Of ",",and
R8713 T12177 T12176 arg2Of cytokines,","
R8714 T12178 T12174 arg2Of and,of
R8715 T12181 T12178 arg2Of IFNs,and
R8716 T12181 T12179 arg1Of IFNs,type
R8717 T12181 T12180 arg1Of IFNs,I
R8718 T12183 T12182 arg2Of to,compared
R8719 T12186 T12183 arg2Of mice,to
R8720 T12186 T12184 arg1Of mice,wild
R8721 T12186 T12185 arg1Of mice,type
R8722 T12188 T12187 arg2Of response,in
R8723 T12188 T12189 arg1Of response,to
R8724 T12191 T12190 arg1Of vitro,in
R8725 T12192 T12189 arg2Of infection,to
R8726 T12192 T12191 arg1Of infection,vitro
R8727 T12196 T12195 arg1Of vivo,in
R8728 T12197 T12196 arg1Of infection,vivo
R8729 T12197 T12198 arg1Of infection,with
R8730 T12197 T12200 arg1Of infection,resulted
R8731 T12199 T12198 arg2Of IAV,with
R8732 T12200 T12193 arg1Of resulted,Similarly
R8733 T12200 T12194 arg1Of resulted,","
R8734 T12200 T12201 arg1Of resulted,in
R8735 T12203 T12201 arg2Of levels,in
R8736 T12203 T12202 arg1Of levels,higher
R8737 T12203 T12204 arg1Of levels,of
R8738 T12206 T12204 arg2Of neutrophil,of
R8739 T12206 T12205 arg1Of neutrophil,primarily
R8740 T12206 T12207 arg1Of neutrophil,attracting
R8741 T12208 T12207 arg2Of chemokines,attracting
R8742 T12208 T12210 arg1Of chemokines,as
R8743 T12208 T12225 arg1Of chemokines,in
R8744 T12210 T12209 arg1Of as,such
R8745 T12211 T12212 arg1Of KC,and
R8746 T12212 T12214 arg1Of and,and
R8747 T12213 T12212 arg2Of MIP-2,and
R8748 T12214 T12210 arg2Of and,as
R8749 T12217 T12214 arg2Of cytokines,and
R8750 T12217 T12215 arg1Of cytokines,several
R8751 T12217 T12216 arg1Of cytokines,proinflammatory
R8752 T12217 T12219 arg1Of cytokines,as
R8753 T12219 T12218 arg1Of as,such
R8754 T12220 T12221 arg1Of IL-6,","
R8755 T12221 T12223 arg1Of ",",and
R8756 T12222 T12221 arg2Of TNF,","
R8757 T12223 T12219 arg2Of and,as
R8758 T12224 T12223 arg2Of IL-1β,and
R8759 T12227 T12225 arg2Of lungs,in
R8760 T12227 T12226 arg1Of lungs,the
R8761 T12227 T12228 arg1Of lungs,of
R8762 T12230 T12228 arg2Of mice,of
R8763 T12230 T12229 arg1Of mice,A20myel-KO
R8764 T12230 T12231 arg2Of mice,compared
R8765 T12231 T12232 arg1Of compared,to
R8766 T12235 T12232 arg2Of mice,to
R8767 T12235 T12233 arg1Of mice,wild
R8768 T12235 T12234 arg1Of mice,type
R8769 T12236 T12237 arg1Of This,was
R8770 T12236 T12238 arg2Of This,associated
R8771 T12236 T12252 arg1Of This,resulted
R8772 T12238 T12237 arg2Of associated,was
R8773 T12238 T12239 arg1Of associated,with
R8774 T12238 T12251 arg1Of associated,and
R8775 T12242 T12239 arg2Of enhancement,with
R8776 T12242 T12240 arg1Of enhancement,a
R8777 T12242 T12241 arg1Of enhancement,selective
R8778 T12242 T12243 arg1Of enhancement,of
R8779 T12245 T12243 arg2Of recruitment,of
R8780 T12245 T12244 arg1Of recruitment,neutrophil
R8781 T12245 T12246 arg1Of recruitment,to
R8782 T12249 T12246 arg2Of compartment,to
R8783 T12249 T12247 arg1Of compartment,the
R8784 T12249 T12248 arg1Of compartment,bronchoalveolar
R8785 T12251 T12250 arg1Of and,","
R8786 T12252 T12251 arg2Of resulted,and
R8787 T12252 T12253 arg1Of resulted,in
R8788 T12252 T12257 arg1Of resulted,later
R8789 T12252 T12259 arg1Of resulted,during
R8790 T12256 T12253 arg2Of clearance,in
R8791 T12256 T12254 arg2Of clearance,improved
R8792 T12256 T12255 arg1Of clearance,viral
R8793 T12257 T12258 arg1Of later,on
R8794 T12260 T12259 arg2Of infection,during
R8795 T12263 T12262 arg1Of role,the
R8796 T12263 T12264 arg1Of role,of
R8797 T12263 T12266 arg1Of role,during
R8798 T12263 T12269 arg1Of role,is
R8799 T12263 T12271 arg1Of role,under
R8800 T12265 T12264 arg2Of neutrophils,of
R8801 T12268 T12266 arg2Of infection,during
R8802 T12268 T12267 arg1Of infection,viral
R8803 T12269 T12261 arg2Of is,Although
R8804 T12269 T12270 arg1Of is,still
R8805 T12271 T12269 arg2Of under,is
R8806 T12272 T12271 arg2Of debate,under
R8807 T12275 T12274 arg1Of evidence,recent
R8808 T12275 T12276 arg1Of evidence,supports
R8809 T12276 T12261 arg1Of supports,Although
R8810 T12276 T12273 arg1Of supports,","
R8811 T12276 T12283 arg1Of supports,during
R8812 T12276 T12289 arg1Of supports,","
R8813 T12276 T12290 arg1Of supports,[
R8814 T12279 T12276 arg2Of function,supports
R8815 T12279 T12277 arg1Of function,a
R8816 T12279 T12278 arg1Of function,protective
R8817 T12279 T12280 arg1Of function,of
R8818 T12282 T12280 arg2Of cells,of
R8819 T12282 T12281 arg1Of cells,these
R8820 T12285 T12283 arg2Of infection,during
R8821 T12285 T12284 arg1Of infection,IAV
R8822 T12285 T12286 arg1Of infection,[
R8823 T12287 T12286 arg2Of 71,[
R8824 T12288 T12286 arg3Of ],[
R8825 T12291 T12290 arg2Of 72,[
R8826 T12292 T12290 arg3Of ],[
R8827 T12294 T12293 arg1Of levels,MCP-1
R8828 T12294 T12295 arg1Of levels,were
R8829 T12294 T12297 arg2Of levels,affected
R8830 T12297 T12295 arg2Of affected,were
R8831 T12297 T12296 arg1Of affected,not
R8832 T12300 T12297 arg1Of absence,affected
R8833 T12300 T12298 arg2Of absence,by
R8834 T12300 T12299 arg1Of absence,the
R8835 T12300 T12301 arg1Of absence,of
R8836 T12300 T12303 arg1Of absence,in
R8837 T12300 T12306 arg1Of absence,","
R8838 T12300 T12307 arg1Of absence,which
R8839 T12300 T12308 arg1Of absence,is
R8840 T12300 T12309 arg1Of absence,consistent
R8841 T12302 T12301 arg2Of A20,of
R8842 T12305 T12303 arg2Of cells,in
R8843 T12305 T12304 arg1Of cells,myeloid
R8844 T12309 T12308 arg2Of consistent,is
R8845 T12309 T12310 arg1Of consistent,with
R8846 T12312 T12310 arg2Of notion,with
R8847 T12312 T12311 arg1Of notion,the
R8848 T12316 T12314 arg1Of cells,airway
R8849 T12316 T12315 arg1Of cells,epithelial
R8850 T12316 T12317 arg1Of cells,are
R8851 T12317 T12312 arg2Of are,notion
R8852 T12317 T12313 arg1Of are,that
R8853 T12317 T12327 arg1Of are,[
R8854 T12320 T12317 arg2Of source,are
R8855 T12320 T12318 arg1Of source,the
R8856 T12320 T12319 arg1Of source,primary
R8857 T12320 T12321 arg1Of source,of
R8858 T12320 T12324 arg1Of source,during
R8859 T12323 T12321 arg2Of production,of
R8860 T12323 T12322 arg1Of production,MCP-1
R8861 T12326 T12324 arg2Of infection,during
R8862 T12326 T12325 arg1Of infection,IAV
R8863 T12328 T12327 arg2Of 73,[
R8864 T12329 T12327 arg3Of ],[
R8865 T12330 T12331 arg1Of Mice,deficient
R8866 T12330 T12348 arg1Of Mice,are
R8867 T12330 T12349 arg2Of Mice,protected
R8868 T12331 T12332 arg1Of deficient,for
R8869 T12336 T12332 arg2Of CCR2,for
R8870 T12336 T12333 arg1Of CCR2,the
R8871 T12336 T12334 arg1Of CCR2,MCP-1
R8872 T12336 T12335 arg1Of CCR2,receptor
R8873 T12336 T12337 arg1Of CCR2,","
R8874 T12336 T12338 arg1Of CCR2,which
R8875 T12336 T12339 arg1Of CCR2,is
R8876 T12336 T12340 arg2Of CCR2,expressed
R8877 T12340 T12339 arg2Of expressed,is
R8878 T12340 T12341 arg1Of expressed,on
R8879 T12343 T12341 arg2Of subset,on
R8880 T12343 T12342 arg1Of subset,a
R8881 T12343 T12344 arg1Of subset,of
R8882 T12346 T12344 arg2Of monocytes,of
R8883 T12346 T12345 arg1Of monocytes,circulating
R8884 T12349 T12347 arg1Of protected,","
R8885 T12349 T12348 arg2Of protected,are
R8886 T12349 T12350 arg1Of protected,against
R8887 T12352 T12351 arg1Of infection,IAV
R8888 T12352 T12353 arg1Of infection,and
R8889 T12353 T12350 arg2Of and,against
R8890 T12356 T12353 arg2Of signs,and
R8891 T12356 T12354 arg1Of signs,display
R8892 T12356 T12355 arg2Of signs,reduced
R8893 T12356 T12357 arg1Of signs,of
R8894 T12360 T12359 arg2Of 74,[
R8895 T12361 T12359 arg3Of ],[
R8896 T12362 T12357 arg2Of –,of
R8897 T12362 T12358 arg1Of –,immunopathology
R8898 T12362 T12359 arg1Of –,[
R8899 T12362 T12363 arg1Of –,[
R8900 T12364 T12363 arg2Of 76,[
R8901 T12365 T12363 arg3Of ],[
R8902 T12368 T12366 arg2Of infection,During
R8903 T12368 T12367 arg1Of infection,IAV
R8904 T12370 T12369 arg1Of monocytes,these
R8905 T12370 T12371 arg1Of monocytes,develop
R8906 T12370 T12383 arg1Of monocytes,are
R8907 T12370 T12384 arg2Of monocytes,considered
R8908 T12371 T12372 arg1Of develop,into
R8909 T12371 T12382 arg1Of develop,and
R8910 T12375 T12373 arg1Of cells,inflammatory
R8911 T12375 T12374 arg1Of cells,dendritic
R8912 T12375 T12376 arg1Of cells,or
R8913 T12376 T12372 arg2Of or,into
R8914 T12378 T12376 arg2Of macrophages,or
R8915 T12378 T12377 arg1Of macrophages,proinflammatory
R8916 T12378 T12379 arg1Of macrophages,[
R8917 T12380 T12379 arg2Of 77,[
R8918 T12381 T12379 arg3Of ],[
R8919 T12382 T12366 arg1Of and,During
R8920 T12384 T12382 arg2Of considered,and
R8921 T12384 T12383 arg2Of considered,are
R8922 T12386 T12384 arg3Of contributors,considered
R8923 T12386 T12385 arg1Of contributors,major
R8924 T12386 T12387 arg1Of contributors,to
R8925 T12389 T12387 arg2Of immunopathology,to
R8926 T12389 T12388 arg1Of immunopathology,IAV-induced
R8927 T12389 T12390 arg1Of immunopathology,[
R8928 T12391 T12390 arg2Of 78,[
R8929 T12392 T12390 arg3Of ],[
R8930 T12394 T12393 arg1Of mice,A20myel-KO
R8931 T12394 T12395 arg1Of mice,were
R8932 T12394 T12396 arg2Of mice,protected
R8933 T12396 T12395 arg2Of protected,were
R8934 T12396 T12397 arg1Of protected,against
R8935 T12401 T12397 arg2Of infection,against
R8936 T12401 T12398 arg1Of infection,a
R8937 T12401 T12399 arg1Of infection,lethal
R8938 T12401 T12400 arg1Of infection,IAV
R8939 T12401 T12402 arg1Of infection,","
R8940 T12401 T12403 arg1Of infection,which
R8941 T12401 T12404 arg1Of infection,is
R8942 T12401 T12406 arg1Of infection,surprising
R8943 T12404 T12407 arg1Of is,since
R8944 T12406 T12404 arg2Of surprising,is
R8945 T12406 T12405 arg1Of surprising,rather
R8946 T12412 T12408 arg1Of response,an
R8947 T12412 T12409 arg1Of response,excessive
R8948 T12412 T12410 arg1Of response,proinflammatory
R8949 T12412 T12411 arg1Of response,cytokine
R8950 T12412 T12413 arg1Of response,and
R8951 T12413 T12420 arg1Of and,is
R8952 T12413 T12422 arg2Of and,believed
R8953 T12413 T12424 arg1Of and,be
R8954 T12413 T12425 arg2Of and,associated
R8955 T12416 T12413 arg2Of influx,and
R8956 T12416 T12414 arg1Of influx,an
R8957 T12416 T12415 arg1Of influx,excessive
R8958 T12416 T12417 arg1Of influx,of
R8959 T12419 T12417 arg2Of cells,of
R8960 T12419 T12418 arg1Of cells,inflammatory
R8961 T12422 T12407 arg2Of believed,since
R8962 T12422 T12420 arg2Of believed,is
R8963 T12422 T12421 arg1Of believed,generally
R8964 T12422 T12432 arg1Of believed,","
R8965 T12422 T12433 arg1Of believed,[
R8966 T12425 T12422 arg3Of associated,believed
R8967 T12425 T12423 arg1Of associated,to
R8968 T12425 T12424 arg2Of associated,be
R8969 T12425 T12426 arg1Of associated,with
R8970 T12428 T12426 arg2Of lethality,with
R8971 T12428 T12427 arg2Of lethality,increased
R8972 T12428 T12429 arg1Of lethality,[
R8973 T12430 T12429 arg2Of 64,[
R8974 T12431 T12429 arg3Of ],[
R8975 T12434 T12433 arg2Of 79,[
R8976 T12435 T12433 arg3Of ],[
R8977 T12440 T12438 arg1Of effect,the
R8978 T12440 T12439 arg1Of effect,selective
R8979 T12440 T12441 arg1Of effect,of
R8980 T12440 T12444 arg1Of effect,on
R8981 T12440 T12449 arg1Of effect,altering
R8982 T12440 T12459 arg1Of effect,support
R8983 T12443 T12441 arg2Of deficiency,of
R8984 T12443 T12442 arg1Of deficiency,A20
R8985 T12446 T12444 arg2Of recruitment,on
R8986 T12446 T12445 arg1Of recruitment,neutrophil
R8987 T12449 T12448 arg2Of altering,without
R8988 T12451 T12450 arg1Of monocyte,inflammatory
R8989 T12451 T12452 arg1Of monocyte,(
R8990 T12454 T12452 arg2Of CD11b+,(
R8991 T12454 T12453 arg1Of CD11b+,Ly6C+
R8992 T12455 T12452 arg3Of ),(
R8993 T12456 T12449 arg2Of recruitment,altering
R8994 T12456 T12451 arg1Of recruitment,monocyte
R8995 T12459 T12436 arg1Of support,However
R8996 T12459 T12437 arg1Of support,","
R8997 T12459 T12447 arg1Of support,","
R8998 T12459 T12448 arg1Of support,without
R8999 T12459 T12457 arg1Of support,","
R9000 T12459 T12458 arg1Of support,further
R9001 T12461 T12459 arg2Of idea,support
R9002 T12461 T12460 arg1Of idea,the
R9003 T12463 T12464 arg1Of monocytes,and
R9004 T12464 T12467 arg1Of and,are
R9005 T12466 T12464 arg2Of neutrophils,and
R9006 T12466 T12465 arg1Of neutrophils,not
R9007 T12467 T12461 arg2Of are,idea
R9008 T12467 T12462 arg1Of are,that
R9009 T12469 T12467 arg2Of contributors,are
R9010 T12469 T12468 arg1Of contributors,major
R9011 T12469 T12470 arg1Of contributors,to
R9012 T12472 T12471 arg1Of immunopathology,IAV-associated
R9013 T12472 T12473 arg1Of immunopathology,and
R9014 T12473 T12470 arg2Of and,to
R9015 T12474 T12473 arg2Of lethality,and
R9016 T12474 T12475 arg1Of lethality,[
R9017 T12476 T12475 arg2Of 78,[
R9018 T12477 T12475 arg3Of ],[
R9019 T12478 T12479 arg1Of We,show
R9020 T12484 T12481 arg1Of display,A20
R9021 T12484 T12482 arg1Of display,deficient
R9022 T12484 T12483 arg1Of display,BMDM
R9023 T12484 T12485 arg1Of display,enhanced
R9024 T12485 T12479 arg2Of enhanced,show
R9025 T12485 T12480 arg1Of enhanced,that
R9026 T12486 T12487 arg1Of NF-κB,and
R9027 T12488 T12487 arg2Of IRF3,and
R9028 T12489 T12485 arg2Of activation,enhanced
R9029 T12489 T12486 arg1Of activation,NF-κB
R9030 T12489 T12488 arg1Of activation,IRF3
R9031 T12489 T12490 arg1Of activation,in
R9032 T12489 T12495 arg1Of activation,by
R9033 T12490 T12492 arg1Of in,to
R9034 T12491 T12490 arg2Of response,in
R9035 T12494 T12490 arg3Of stimulation,in
R9036 T12494 T12493 arg1Of stimulation,RIG-I
R9037 T12498 T12496 arg1Of double,synthetic
R9038 T12498 T12497 arg1Of double,LMW
R9039 T12500 T12495 arg2Of RNA,by
R9040 T12500 T12498 arg1Of RNA,double
R9041 T12500 T12499 arg1Of RNA,stranded
R9042 T12501 T12502 arg1Of RIG-I,has
R9043 T12501 T12504 arg1Of RIG-I,been
R9044 T12501 T12505 arg2Of RIG-I,shown
R9045 T12501 T12507 arg1Of RIG-I,play
R9046 T12505 T12502 arg2Of shown,has
R9047 T12505 T12503 arg1Of shown,previously
R9048 T12505 T12504 arg2Of shown,been
R9049 T12507 T12505 arg3Of play,shown
R9050 T12507 T12506 arg1Of play,to
R9051 T12507 T12511 arg1Of play,in
R9052 T12507 T12521 arg1Of play,","
R9053 T12507 T12522 modOf play,suggesting
R9054 T12510 T12507 arg2Of role,play
R9055 T12510 T12508 arg1Of role,a
R9056 T12510 T12509 arg1Of role,key
R9057 T12515 T12511 arg2Of response,in
R9058 T12515 T12512 arg1Of response,the
R9059 T12515 T12513 arg1Of response,innate
R9060 T12515 T12514 arg1Of response,immune
R9061 T12515 T12516 arg1Of response,to
R9062 T12517 T12516 arg2Of IAV,to
R9063 T12517 T12518 arg1Of IAV,[
R9064 T12519 T12518 arg2Of 13,[
R9065 T12520 T12518 arg3Of ],[
R9066 T12527 T12524 arg1Of response,the
R9067 T12527 T12525 arg2Of response,increased
R9068 T12527 T12526 arg1Of response,immune
R9069 T12527 T12528 arg1Of response,of
R9070 T12527 T12531 arg1Of response,to
R9071 T12527 T12535 arg1Of response,reflects
R9072 T12530 T12528 arg2Of mice,of
R9073 T12530 T12529 arg1Of mice,A20myel-KO
R9074 T12534 T12531 arg2Of infection,to
R9075 T12534 T12532 arg1Of infection,IAV
R9076 T12534 T12533 arg1Of infection,lung
R9077 T12535 T12522 arg2Of reflects,suggesting
R9078 T12535 T12523 arg1Of reflects,that
R9079 T12538 T12535 arg2Of signaling,reflects
R9080 T12538 T12536 arg2Of signaling,enhanced
R9081 T12538 T12537 arg1Of signaling,RIG-I
R9082 T12539 T12540 arg1Of We,propose
R9083 T12542 T12543 arg1Of A20,inhibits
R9084 T12543 T12540 arg2Of inhibits,propose
R9085 T12543 T12541 arg1Of inhibits,that
R9086 T12543 T12548 arg1Of inhibits,(
R9087 T12543 T12566 arg1Of inhibits,by
R9088 T12547 T12543 arg2Of expression,inhibits
R9089 T12547 T12544 arg1Of expression,IAV-induced
R9090 T12547 T12545 arg1Of expression,proinflammatory
R9091 T12547 T12546 arg1Of expression,gene
R9092 T12549 T12548 arg2Of as,(
R9093 T12550 T12549 arg2Of shown,as
R9094 T12550 T12551 arg1Of shown,in
R9095 T12553 T12551 arg2Of manuscript,in
R9096 T12553 T12552 arg1Of manuscript,our
R9097 T12553 T12554 arg1Of manuscript,for
R9098 T12555 T12556 arg1Of TNF,","
R9099 T12556 T12558 arg1Of ",",","
R9100 T12557 T12556 arg2Of IL-6,","
R9101 T12558 T12560 arg1Of ",",","
R9102 T12559 T12558 arg2Of KC,","
R9103 T12560 T12563 arg1Of ",",and
R9104 T12561 T12560 arg2Of MIP-2,","
R9105 T12563 T12554 arg2Of and,for
R9106 T12563 T12562 arg1Of and,","
R9107 T12564 T12563 arg2Of IFNβ,and
R9108 T12565 T12548 arg3Of ),(
R9109 T12568 T12566 arg2Of regulating,by
R9110 T12568 T12567 arg1Of regulating,negatively
R9111 T12569 T12570 arg1Of NF-κB,and
R9112 T12571 T12570 arg2Of IRF3,and
R9113 T12572 T12568 arg2Of activation,regulating
R9114 T12572 T12569 arg1Of activation,NF-κB
R9115 T12572 T12571 arg1Of activation,IRF3
R9116 T12572 T12573 arg1Of activation,","
R9117 T12572 T12574 arg1Of activation,which
R9118 T12572 T12575 arg1Of activation,are
R9119 T12578 T12575 arg2Of pathways,are
R9120 T12578 T12576 arg1Of pathways,the
R9121 T12578 T12577 arg1Of pathways,major
R9122 T12578 T12579 arg1Of pathways,controlling
R9123 T12581 T12579 arg2Of genes,controlling
R9124 T12581 T12580 arg1Of genes,these
R9125 T12584 T12585 arg1Of this,does
R9126 T12584 T12587 arg1Of this,exclude
R9127 T12587 T12582 arg1Of exclude,However
R9128 T12587 T12583 arg1Of exclude,","
R9129 T12587 T12585 arg2Of exclude,does
R9130 T12587 T12586 arg1Of exclude,not
R9131 T12590 T12587 arg2Of effect,exclude
R9132 T12590 T12588 arg1Of effect,an
R9133 T12590 T12589 arg1Of effect,additional
R9134 T12590 T12591 arg1Of effect,of
R9135 T12590 T12593 arg1Of effect,on
R9136 T12592 T12591 arg2Of A20,of
R9137 T12596 T12593 arg2Of pathways,on
R9138 T12596 T12594 arg1Of pathways,other
R9139 T12596 T12595 arg1Of pathways,signaling
R9140 T12596 T12597 arg1Of pathways,that
R9141 T12596 T12598 arg1Of pathways,may
R9142 T12596 T12599 arg1Of pathways,contribute
R9143 T12599 T12598 arg2Of contribute,may
R9144 T12599 T12600 arg1Of contribute,to
R9145 T12603 T12600 arg2Of expression,to
R9146 T12603 T12601 arg1Of expression,proinflammatory
R9147 T12603 T12602 arg1Of expression,gene
R9148 T12604 T12605 arg1Of A20,is
R9149 T12604 T12606 arg2Of A20,believed
R9150 T12604 T12608 arg1Of A20,exert
R9151 T12604 T12616 arg1Of A20,modulating
R9152 T12606 T12605 arg2Of believed,is
R9153 T12608 T12606 arg3Of exert,believed
R9154 T12608 T12607 arg1Of exert,to
R9155 T12608 T12615 arg1Of exert,by
R9156 T12608 T12624 arg1Of exert,[
R9157 T12610 T12611 arg1Of NF-κB,and
R9158 T12612 T12611 arg2Of IRF3,and
R9159 T12614 T12608 arg2Of functions,exert
R9160 T12614 T12609 arg1Of functions,its
R9161 T12614 T12610 arg1Of functions,NF-κB
R9162 T12614 T12612 arg1Of functions,IRF3
R9163 T12614 T12613 arg1Of functions,inhibitory
R9164 T12616 T12615 arg2Of modulating,by
R9165 T12619 T12616 arg2Of status,modulating
R9166 T12619 T12617 arg1Of status,the
R9167 T12619 T12618 arg1Of status,ubiquitination
R9168 T12619 T12620 arg1Of status,of
R9169 T12623 T12620 arg2Of proteins,of
R9170 T12623 T12621 arg1Of proteins,different
R9171 T12623 T12622 arg1Of proteins,signaling
R9172 T12625 T12624 arg2Of 80,[
R9173 T12626 T12624 arg3Of ],[
R9174 T12629 T12627 arg2Of context,In
R9175 T12629 T12628 arg1Of context,this
R9176 T12631 T12632 arg1Of it,was
R9177 T12631 T12634 arg2Of it,shown
R9178 T12634 T12627 arg1Of shown,In
R9179 T12634 T12630 arg1Of shown,","
R9180 T12634 T12632 arg2Of shown,was
R9181 T12634 T12633 arg1Of shown,recently
R9182 T12636 T12637 arg1Of A20,cooperates
R9183 T12637 T12634 arg3Of cooperates,shown
R9184 T12637 T12635 arg1Of cooperates,that
R9185 T12637 T12638 arg1Of cooperates,with
R9186 T12637 T12645 arg1Of cooperates,to
R9187 T12637 T12651 arg1Of cooperates,","
R9188 T12637 T12654 modOf cooperates,affecting
R9189 T12641 T12639 arg1Of proteins,the
R9190 T12641 T12640 arg1Of proteins,ubiquitin-binding
R9191 T12642 T12643 arg1Of TAX1BP1,and
R9192 T12643 T12638 arg2Of and,with
R9193 T12643 T12641 arg1Of and,proteins
R9194 T12644 T12643 arg2Of ABIN1,and
R9195 T12647 T12637 arg2Of disrupt,cooperates
R9196 T12647 T12646 arg1Of disrupt,to
R9197 T12650 T12647 arg2Of complex,disrupt
R9198 T12650 T12648 arg1Of complex,the
R9199 T12650 T12649 arg1Of complex,TRAF3-TBK1-IKKε
R9200 T12654 T12652 arg1Of affecting,thereby
R9201 T12654 T12653 arg1Of affecting,negatively
R9202 T12654 T12670 arg1Of affecting,","
R9203 T12654 T12671 arg1Of affecting,[
R9204 T12655 T12654 arg2Of K63-polyubiquitination,affecting
R9205 T12655 T12656 arg1Of K63-polyubiquitination,of
R9206 T12657 T12658 arg1Of TBK1,and
R9207 T12658 T12661 arg1Of and,and
R9208 T12659 T12658 arg2Of IKKε,and
R9209 T12661 T12656 arg2Of and,of
R9210 T12661 T12660 arg1Of and,","
R9211 T12663 T12661 arg2Of ability,and
R9212 T12663 T12662 arg1Of ability,their
R9213 T12663 T12664 arg1Of ability,to
R9214 T12666 T12664 arg2Of IRF3,to
R9215 T12666 T12665 arg1Of IRF3,activity
R9216 T12666 T12667 arg1Of IRF3,[
R9217 T12668 T12667 arg2Of 81,[
R9218 T12669 T12667 arg3Of ],[
R9219 T12672 T12671 arg2Of 82,[
R9220 T12673 T12671 arg3Of ],[
R9221 T12676 T12675 arg1Of mechanisms,similar
R9222 T12676 T12677 arg1Of mechanisms,are
R9223 T12676 T12678 arg2Of mechanisms,involved
R9224 T12678 T12674 arg1Of involved,Whether
R9225 T12678 T12677 arg2Of involved,are
R9226 T12678 T12679 arg1Of involved,in
R9227 T12678 T12687 arg1Of involved,is
R9228 T12678 T12689 arg1Of involved,unclear
R9229 T12681 T12679 arg2Of regulation,in
R9230 T12681 T12680 arg1Of regulation,the
R9231 T12681 T12682 arg1Of regulation,of
R9232 T12683 T12682 arg2Of RIG-I,of
R9233 T12686 T12679 arg3Of activation,in
R9234 T12686 T12684 arg2Of activation,induced
R9235 T12686 T12685 arg1Of activation,NF-κB
R9236 T12687 T12688 arg1Of is,still
R9237 T12689 T12687 arg2Of unclear,is
R9238 T12691 T12690 arg1Of far,So
R9239 T12692 T12693 arg1Of we,were
R9240 T12692 T12694 arg1Of we,unable
R9241 T12692 T12697 arg1Of we,detect
R9242 T12692 T12707 arg1Of we,preventing
R9243 T12693 T12691 arg1Of were,far
R9244 T12694 T12693 arg2Of unable,were
R9245 T12697 T12694 arg2Of detect,unable
R9246 T12697 T12695 arg1Of detect,to
R9247 T12697 T12696 arg1Of detect,clearly
R9248 T12697 T12706 arg1Of detect,","
R9249 T12697 T12707 modOf detect,preventing
R9250 T12698 T12697 arg2Of ubiquitination,detect
R9251 T12698 T12699 arg1Of ubiquitination,of
R9252 T12698 T12703 arg1Of ubiquitination,in
R9253 T12700 T12701 arg1Of TBK1,and
R9254 T12701 T12699 arg2Of and,of
R9255 T12702 T12701 arg2Of IKKε,and
R9256 T12705 T12703 arg2Of macrophages,in
R9257 T12705 T12704 arg1Of macrophages,primary
R9258 T12707 T12709 arg1Of preventing,from
R9259 T12708 T12707 arg2Of us,preventing
R9260 T12710 T12709 arg2Of studying,from
R9261 T12712 T12710 arg2Of effect,studying
R9262 T12712 T12711 arg1Of effect,the
R9263 T12712 T12713 arg1Of effect,of
R9264 T12712 T12716 arg1Of effect,on
R9265 T12715 T12713 arg2Of deficiency,of
R9266 T12715 T12714 arg1Of deficiency,A20
R9267 T12719 T12716 arg2Of status,on
R9268 T12719 T12717 arg1Of status,their
R9269 T12719 T12718 arg1Of status,ubiquitination
R9270 T12720 T12721 arg1Of It,can
R9271 T12720 T12723 arg1Of It,be
R9272 T12720 T12724 arg2Of It,excluded
R9273 T12724 T12721 arg2Of excluded,can
R9274 T12724 T12722 arg1Of excluded,not
R9275 T12724 T12723 arg2Of excluded,be
R9276 T12724 T12725 arg1Of excluded,however
R9277 T12727 T12726 arg1Of A20,that
R9278 T12727 T12729 arg1Of A20,targets
R9279 T12729 T12725 arg2Of targets,however
R9280 T12729 T12728 arg1Of targets,also
R9281 T12731 T12729 arg2Of substrates,targets
R9282 T12731 T12730 arg1Of substrates,other
R9283 T12731 T12732 arg1Of substrates,that
R9284 T12731 T12733 arg1Of substrates,mediate
R9285 T12733 T12738 arg1Of mediate,in
R9286 T12734 T12735 arg1Of NF-κB,and
R9287 T12735 T12733 arg2Of and,mediate
R9288 T12737 T12735 arg2Of activation,and
R9289 T12737 T12736 arg1Of activation,IRF3
R9290 T12740 T12738 arg2Of cells,in
R9291 T12740 T12739 arg1Of cells,myeloid
R9292 T12742 T12741 arg1Of identification,The
R9293 T12742 T12743 arg1Of identification,of
R9294 T12742 T12746 arg1Of identification,will
R9295 T12742 T12747 arg1Of identification,be
R9296 T12745 T12743 arg2Of substrates,of
R9297 T12745 T12744 arg1Of substrates,these
R9298 T12747 T12746 arg2Of be,will
R9299 T12747 T12753 arg1Of be,in
R9300 T12749 T12747 arg2Of topic,be
R9301 T12749 T12748 arg1Of topic,the
R9302 T12749 T12750 arg1Of topic,of
R9303 T12752 T12750 arg2Of investigations,of
R9304 T12752 T12751 arg1Of investigations,future
R9305 T12755 T12753 arg2Of laboratory,in
R9306 T12755 T12754 arg1Of laboratory,our
R9307 T12759 T12756 arg1Of enzymes,Multiple
R9308 T12759 T12757 arg1Of enzymes,other
R9309 T12759 T12758 arg1Of enzymes,deubiquitinating
R9310 T12759 T12760 arg1Of enzymes,(
R9311 T12759 T12763 arg1Of enzymes,","
R9312 T12759 T12765 arg1Of enzymes,as
R9313 T12761 T12760 arg2Of DUBs,(
R9314 T12762 T12760 arg3Of ),(
R9315 T12765 T12764 arg1Of as,such
R9316 T12766 T12767 arg1Of DUBA,[
R9317 T12766 T12770 arg1Of DUBA,","
R9318 T12768 T12767 arg2Of 28,[
R9319 T12769 T12767 arg3Of ],[
R9320 T12770 T12775 arg1Of ",",","
R9321 T12770 T12776 arg1Of ",",[
R9322 T12770 T12779 arg1Of ",",","
R9323 T12770 T12785 arg1Of ",",and
R9324 T12771 T12770 arg2Of CYLD,","
R9325 T12771 T12772 arg1Of CYLD,[
R9326 T12773 T12772 arg2Of 29,[
R9327 T12774 T12772 arg3Of ],[
R9328 T12777 T12776 arg2Of 30,[
R9329 T12778 T12776 arg3Of ],[
R9330 T12780 T12779 arg2Of OTUB1/2,","
R9331 T12780 T12781 arg1Of OTUB1/2,[
R9332 T12782 T12781 arg2Of 31,[
R9333 T12783 T12781 arg3Of ],[
R9334 T12785 T12765 arg2Of and,as
R9335 T12785 T12784 arg1Of and,","
R9336 T12786 T12785 arg2Of A20,and
R9337 T12786 T12787 arg1Of A20,[
R9338 T12786 T12794 modOf A20,have
R9339 T12788 T12787 arg2Of 49,[
R9340 T12789 T12787 arg3Of ],[
R9341 T12790 T12791 arg1Of –,[
R9342 T12790 T12794 arg1Of –,have
R9343 T12790 T12795 arg1Of –,been
R9344 T12790 T12796 arg2Of –,shown
R9345 T12790 T12799 arg1Of –,regulate
R9346 T12792 T12791 arg2Of 52,[
R9347 T12793 T12791 arg3Of ],[
R9348 T12796 T12794 arg2Of shown,have
R9349 T12796 T12795 arg2Of shown,been
R9350 T12796 T12806 arg1Of shown,","
R9351 T12796 T12807 modOf shown,implicating
R9352 T12799 T12796 arg3Of regulate,shown
R9353 T12799 T12797 arg1Of regulate,to
R9354 T12799 T12798 arg1Of regulate,negatively
R9355 T12801 T12799 arg2Of signaling,regulate
R9356 T12801 T12800 arg1Of signaling,RIG-I
R9357 T12801 T12802 arg1Of signaling,to
R9358 T12803 T12804 arg1Of NF-κB,and
R9359 T12804 T12802 arg2Of and,to
R9360 T12805 T12804 arg2Of IRF-3,and
R9361 T12809 T12807 arg2Of redundancy,implicating
R9362 T12809 T12808 arg1Of redundancy,possible
R9363 T12812 T12815 arg1Of evidence,was
R9364 T12812 T12816 arg2Of evidence,limited
R9365 T12812 T12822 arg1Of evidence,was
R9366 T12812 T12823 arg2Of evidence,obtained
R9367 T12814 T12813 arg1Of far,so
R9368 T12816 T12815 arg2Of limited,was
R9369 T12816 T12817 arg1Of limited,to
R9370 T12816 T12821 arg1Of limited,and
R9371 T12819 T12818 arg1Of vitro,in
R9372 T12820 T12817 arg2Of data,to
R9373 T12820 T12819 arg1Of data,vitro
R9374 T12821 T12810 arg1Of and,However
R9375 T12821 T12811 arg1Of and,","
R9376 T12821 T12814 arg1Of and,far
R9377 T12823 T12821 arg2Of obtained,and
R9378 T12823 T12822 arg2Of obtained,was
R9379 T12823 T12824 arg1Of obtained,under
R9380 T12826 T12824 arg2Of conditions,under
R9381 T12826 T12825 arg1Of conditions,non-physiological
R9382 T12830 T12827 arg1Of phenotype,The
R9383 T12830 T12828 arg1Of phenotype,clear
R9384 T12830 T12829 arg1Of phenotype,protective
R9385 T12830 T12831 arg1Of phenotype,of
R9386 T12830 T12834 arg1Of phenotype,that
R9387 T12830 T12837 arg2Of phenotype,describe
R9388 T12830 T12838 arg1Of phenotype,indicates
R9389 T12833 T12831 arg2Of mice,of
R9390 T12833 T12832 arg1Of mice,A20myel-KO
R9391 T12835 T12837 arg1Of we,describe
R9392 T12837 T12836 arg1Of describe,here
R9393 T12841 T12840 arg1Of expression,A20
R9394 T12841 T12842 arg1Of expression,in
R9395 T12841 T12845 arg1Of expression,is
R9396 T12844 T12842 arg2Of cells,in
R9397 T12844 T12843 arg1Of cells,myeloid
R9398 T12845 T12839 arg1Of is,that
R9399 T12845 T12853 arg1Of is,in
R9400 T12845 T12858 arg1Of is,and
R9401 T12848 T12845 arg2Of gatekeeper,is
R9402 T12848 T12846 arg1Of gatekeeper,a
R9403 T12848 T12847 arg1Of gatekeeper,central
R9404 T12848 T12849 arg1Of gatekeeper,of
R9405 T12852 T12849 arg2Of signaling,of
R9406 T12852 T12850 arg1Of signaling,RIG-I
R9407 T12852 T12851 arg2Of signaling,induced
R9408 T12853 T12855 arg1Of in,to
R9409 T12854 T12853 arg2Of response,in
R9410 T12857 T12853 arg3Of infection,in
R9411 T12857 T12856 arg1Of infection,IAV
R9412 T12858 T12838 arg2Of and,indicates
R9413 T12859 T12858 arg2Of that,and
R9414 T12861 T12860 arg1Of DUBs,other
R9415 T12861 T12862 arg1Of DUBs,can
R9416 T12861 T12864 arg1Of DUBs,substitute
R9417 T12864 T12859 arg2Of substitute,that
R9418 T12864 T12862 arg2Of substitute,can
R9419 T12864 T12863 arg1Of substitute,not
R9420 T12864 T12865 arg1Of substitute,for
R9421 T12864 T12868 arg1Of substitute,under
R9422 T12867 T12865 arg2Of deficiency,for
R9423 T12867 T12866 arg1Of deficiency,A20
R9424 T12870 T12868 arg2Of conditions,under
R9425 T12870 T12869 arg1Of conditions,physiological
R9426 T12872 T12873 arg1Of A20,has
R9427 T12873 T12871 arg1Of has,If
R9428 T12873 T12897 arg1Of has,remains
R9429 T12873 T12899 arg1Of has,be
R9430 T12873 T12900 arg2Of has,investigated
R9431 T12877 T12873 arg2Of role,has
R9432 T12877 T12874 arg1Of role,a
R9433 T12877 T12875 arg1Of role,similar
R9434 T12877 T12876 arg1Of role,non-redundant
R9435 T12877 T12878 arg1Of role,in
R9436 T12877 T12890 arg1Of role,","
R9437 T12877 T12892 arg1Of role,as
R9438 T12881 T12878 arg2Of types,in
R9439 T12881 T12879 arg1Of types,other
R9440 T12881 T12880 arg1Of types,cell
R9441 T12881 T12882 arg1Of types,that
R9442 T12881 T12883 arg1Of types,are
R9443 T12881 T12884 arg2Of types,implicated
R9444 T12884 T12883 arg2Of implicated,are
R9445 T12884 T12885 arg1Of implicated,in
R9446 T12887 T12885 arg2Of response,in
R9447 T12887 T12886 arg1Of response,the
R9448 T12887 T12888 arg1Of response,to
R9449 T12889 T12888 arg2Of IAV,to
R9450 T12892 T12891 arg1Of as,such
R9451 T12895 T12892 arg2Of cells,as
R9452 T12895 T12893 arg1Of cells,lung
R9453 T12895 T12894 arg1Of cells,epithelial
R9454 T12897 T12896 arg1Of remains,","
R9455 T12900 T12897 arg2Of investigated,remains
R9456 T12900 T12898 arg1Of investigated,to
R9457 T12900 T12899 arg2Of investigated,be
R9458 T12901 T12902 arg1Of Understanding,and
R9459 T12902 T12911 arg2Of and,is
R9460 T12903 T12902 arg2Of controlling,and
R9461 T12905 T12901 arg2Of activation,Understanding
R9462 T12905 T12903 arg2Of activation,controlling
R9463 T12905 T12904 arg1Of activation,the
R9464 T12905 T12906 arg1Of activation,of
R9465 T12910 T12906 arg2Of responses,of
R9466 T12910 T12907 arg1Of responses,innate
R9467 T12910 T12908 arg1Of responses,antiviral
R9468 T12910 T12909 arg1Of responses,immune
R9469 T12914 T12901 arg1Of step,Understanding
R9470 T12914 T12903 arg1Of step,controlling
R9471 T12914 T12911 arg1Of step,is
R9472 T12914 T12912 arg1Of step,an
R9473 T12914 T12913 arg1Of step,important
R9474 T12914 T12915 arg1Of step,toward
R9475 T12917 T12915 arg2Of therapies,toward
R9476 T12917 T12916 arg1Of therapies,novel
R9477 T12920 T12918 arg1Of fifth,About
R9478 T12920 T12919 arg1Of fifth,a
R9479 T12920 T12921 arg1Of fifth,of
R9480 T12920 T12925 arg1Of fifth,is
R9481 T12920 T12926 arg2Of fifth,infected
R9482 T12922 T12923 arg2Of world,'s
R9483 T12924 T12921 arg2Of population,of
R9484 T12924 T12923 arg1Of population,'s
R9485 T12926 T12925 arg2Of infected,is
R9486 T12926 T12929 arg1Of infected,annually
R9487 T12926 T12930 arg1Of infected,","
R9488 T12926 T12931 modOf infected,leading
R9489 T12926 T12937 arg1Of infected,","
R9490 T12926 T12939 arg1Of infected,in
R9491 T12928 T12926 arg1Of IAV,infected
R9492 T12928 T12927 arg2Of IAV,by
R9493 T12931 T12932 arg1Of leading,to
R9494 T12934 T12935 arg1Of morbidity,and
R9495 T12935 T12932 arg2Of and,to
R9496 T12935 T12933 arg1Of and,high
R9497 T12936 T12935 arg2Of mortality,and
R9498 T12939 T12938 arg1Of in,particularly
R9499 T12940 T12939 arg2Of infants,in
R9500 T12940 T12941 arg1Of infants,","
R9501 T12943 T12942 arg1Of elderly,the
R9502 T12943 T12944 arg1Of elderly,and
R9503 T12944 T12941 arg2Of and,","
R9504 T12946 T12944 arg2Of immunocompromised,and
R9505 T12946 T12945 arg1Of immunocompromised,the
R9506 T12950 T12947 arg1Of rate,The
R9507 T12950 T12948 arg1Of rate,high
R9508 T12950 T12949 arg1Of rate,mutation
R9509 T12950 T12951 arg1Of rate,of
R9510 T12950 T12953 arg1Of rate,turns
R9511 T12952 T12951 arg2Of IAV,of
R9512 T12955 T12953 arg2Of attempts,turns
R9513 T12955 T12954 arg1Of attempts,all
R9514 T12955 T12956 arg1Of attempts,of
R9515 T12955 T12961 arg1Of attempts,into
R9516 T12957 T12958 arg1Of vaccine,and
R9517 T12958 T12956 arg2Of and,of
R9518 T12960 T12958 arg2Of design,and
R9519 T12960 T12959 arg1Of design,antiviral
R9520 T12962 T12964 arg1Of a,ending
R9521 T12964 T12961 arg2Of ending,into
R9522 T12964 T12962 arg1Of ending,a
R9523 T12964 T12963 arg1Of ending,never
R9524 T12965 T12964 arg2Of battle,ending
R9525 T12968 T12966 arg2Of years,In
R9526 T12968 T12967 arg1Of years,recent
R9527 T12971 T12970 arg1Of interference,RNA
R9528 T12971 T12972 arg1Of interference,","
R9529 T12971 T12973 arg2Of interference,triggered
R9530 T12971 T12983 arg1Of interference,has
R9531 T12971 T12985 arg1Of interference,evolved
R9532 T12978 T12973 arg1Of RNA,triggered
R9533 T12978 T12974 arg2Of RNA,by
R9534 T12978 T12975 arg1Of RNA,synthetic
R9535 T12978 T12976 arg1Of RNA,short
R9536 T12978 T12977 arg1Of RNA,interfering
R9537 T12978 T12979 arg1Of RNA,(
R9538 T12980 T12979 arg2Of siRNA,(
R9539 T12981 T12979 arg3Of ),(
R9540 T12985 T12966 arg1Of evolved,In
R9541 T12985 T12969 arg1Of evolved,","
R9542 T12985 T12982 arg1Of evolved,","
R9543 T12985 T12983 arg2Of evolved,has
R9544 T12985 T12984 arg1Of evolved,rapidly
R9545 T12985 T12986 arg1Of evolved,as
R9546 T12990 T12986 arg2Of regimen,as
R9547 T12990 T12987 arg1Of regimen,a
R9548 T12990 T12988 arg1Of regimen,potent
R9549 T12990 T12989 arg1Of regimen,antiviral
R9550 T12992 T12991 arg1Of designed,Properly
R9551 T12993 T12992 arg1Of siRNAs,designed
R9552 T12993 T12994 arg1Of siRNAs,have
R9553 T12993 T12995 arg1Of siRNAs,been
R9554 T12993 T12996 arg2Of siRNAs,shown
R9555 T12993 T12998 arg1Of siRNAs,function
R9556 T12996 T12994 arg2Of shown,have
R9557 T12996 T12995 arg2Of shown,been
R9558 T12998 T12996 arg3Of function,shown
R9559 T12998 T12997 arg1Of function,to
R9560 T12998 T12999 arg1Of function,as
R9561 T13001 T12999 arg2Of inhibitors,as
R9562 T13001 T13000 arg1Of inhibitors,potent
R9563 T13001 T13002 arg1Of inhibitors,of
R9564 T13005 T13002 arg2Of replication,of
R9565 T13005 T13003 arg1Of replication,influenza
R9566 T13005 T13004 arg1Of replication,virus
R9567 T13007 T13008 arg1Of specificity,and
R9568 T13008 T13011 arg1Of and,remain
R9569 T13010 T13008 arg2Of delivery,and
R9570 T13010 T13009 arg1Of delivery,tissue
R9571 T13011 T13006 arg2Of remain,Although
R9572 T13011 T13014 arg1Of remain,in
R9573 T13011 T13020 arg1Of remain,in
R9574 T13013 T13011 arg2Of bottlenecks,remain
R9575 T13013 T13012 arg1Of bottlenecks,major
R9576 T13017 T13014 arg2Of applications,in
R9577 T13017 T13015 arg1Of applications,the
R9578 T13017 T13016 arg1Of applications,clinical
R9579 T13017 T13018 arg1Of applications,of
R9580 T13019 T13018 arg2Of RNAi,of
R9581 T13021 T13020 arg2Of general,in
R9582 T13024 T13023 arg1Of application,intranasal
R9583 T13024 T13025 arg1Of application,of
R9584 T13024 T13027 arg1Of application,against
R9585 T13024 T13034 arg2Of application,limited
R9586 T13024 T13039 arg1Of application,has
R9587 T13024 T13040 arg1Of application,experienced
R9588 T13026 T13025 arg2Of siRNA,of
R9589 T13029 T13027 arg2Of viruses,against
R9590 T13029 T13028 arg1Of viruses,respiratory
R9591 T13029 T13030 arg1Of viruses,including
R9592 T13030 T13032 arg1Of including,but
R9593 T13032 T13031 arg1Of but,","
R9594 T13032 T13033 arg1Of but,not
R9595 T13034 T13035 arg1Of limited,to
R9596 T13037 T13035 arg2Of virus,to
R9597 T13037 T13036 arg1Of virus,influenza
R9598 T13040 T13006 arg1Of experienced,Although
R9599 T13040 T13022 arg1Of experienced,","
R9600 T13040 T13038 arg1Of experienced,","
R9601 T13040 T13039 arg2Of experienced,has
R9602 T13042 T13041 arg1Of success,significant
R9603 T13042 T13043 arg1Of success,and
R9604 T13043 T13040 arg2Of and,experienced
R9605 T13044 T13043 arg2Of optimism,and
R9606 T13044 T13045 arg1Of optimism,[
R9607 T13046 T13045 arg2Of 83,[
R9608 T13047 T13045 arg3Of ],[
R9609 T13049 T13048 arg1Of results,Our
R9610 T13049 T13050 arg1Of results,suggest
R9611 T13053 T13052 arg1Of only,not
R9612 T13054 T13053 arg1Of siRNA,only
R9613 T13054 T13055 arg1Of siRNA,targeting
R9614 T13054 T13060 arg1Of siRNA,boosting
R9615 T13054 T13072 arg1Of siRNA,might
R9616 T13054 T13073 arg1Of siRNA,be
R9617 T13055 T13059 arg1Of targeting,but
R9618 T13057 T13055 arg2Of components,targeting
R9619 T13057 T13056 arg1Of components,IAV
R9620 T13059 T13058 arg1Of but,","
R9621 T13060 T13059 arg2Of boosting,but
R9622 T13064 T13060 arg2Of response,boosting
R9623 T13064 T13061 arg1Of response,the
R9624 T13064 T13062 arg1Of response,antiviral
R9625 T13064 T13063 arg1Of response,immune
R9626 T13064 T13065 arg1Of response,by
R9627 T13067 T13065 arg2Of administration,by
R9628 T13067 T13066 arg1Of administration,intranasal
R9629 T13067 T13068 arg1Of administration,of
R9630 T13067 T13070 arg1Of administration,against
R9631 T13069 T13068 arg2Of siRNA,of
R9632 T13071 T13070 arg2Of A20,against
R9633 T13073 T13050 arg2Of be,suggest
R9634 T13073 T13051 arg1Of be,that
R9635 T13073 T13072 arg2Of be,might
R9636 T13076 T13075 arg1Of therapeutic,valid
R9637 T13077 T13073 arg2Of approach,be
R9638 T13077 T13074 arg1Of approach,a
R9639 T13077 T13076 arg1Of approach,therapeutic
R9640 T13079 T13078 arg1Of small,Also
R9641 T13081 T13079 arg1Of inhibitors,small
R9642 T13081 T13080 arg1Of inhibitors,compound
R9643 T13081 T13082 arg1Of inhibitors,of
R9644 T13081 T13084 arg1Of inhibitors,might
R9645 T13081 T13085 arg1Of inhibitors,be
R9646 T13083 T13082 arg2Of A20,of
R9647 T13085 T13084 arg2Of be,might
R9648 T13088 T13085 arg2Of alternative,be
R9649 T13088 T13086 arg1Of alternative,an
R9650 T13088 T13087 arg1Of alternative,interesting
R9651 T13092 T13091 arg1Of targeting,similar
R9652 T13092 T13093 arg1Of targeting,of
R9653 T13092 T13095 arg1Of targeting,might
R9654 T13092 T13096 arg1Of targeting,be
R9655 T13092 T13097 arg1Of targeting,of
R9656 T13094 T13093 arg2Of A20,of
R9657 T13096 T13089 arg1Of be,Finally
R9658 T13096 T13090 arg1Of be,","
R9659 T13096 T13095 arg2Of be,might
R9660 T13097 T13096 arg2Of of,be
R9661 T13098 T13097 arg2Of interest,of
R9662 T13098 T13099 arg1Of interest,in
R9663 T13101 T13099 arg2Of battle,in
R9664 T13101 T13100 arg1Of battle,the
R9665 T13101 T13102 arg1Of battle,against
R9666 T13105 T13102 arg2Of infections,against
R9667 T13105 T13103 arg1Of infections,other
R9668 T13105 T13104 arg1Of infections,viral
R9669 T13105 T13106 arg1Of infections,including
R9670 T13107 T13108 arg1Of RSV,and
R9671 T13108 T13106 arg2Of and,including
R9672 T13110 T13108 arg2Of coronavirus,and
R9673 T13110 T13109 arg1Of coronavirus,SARS
R10962 T14803 T14802 arg1Of statement,Ethics
R10963 T14805 T14804 arg1Of experiments,All
R10964 T14805 T14806 arg1Of experiments,on
R10965 T14805 T14808 arg1Of experiments,were
R10966 T14805 T14809 arg2Of experiments,conducted
R10967 T14807 T14806 arg2Of mice,on
R10968 T14809 T14808 arg2Of conducted,were
R10969 T14809 T14810 arg1Of conducted,according
R10970 T14811 T14810 arg2Of to,according
R10971 T14813 T14814 arg1Of national,(
R10972 T14813 T14826 arg1Of national,and
R10973 T14816 T14815 arg1Of Law,Belgian
R10974 T14816 T14817 arg1Of Law,14/08/1986
R10975 T14816 T14818 arg1Of Law,and
R10976 T14818 T14814 arg2Of and,(
R10977 T14819 T14818 arg2Of 22/12/2003,and
R10978 T14819 T14820 arg1Of 22/12/2003,","
R10979 T14823 T14820 arg2Of Decree,","
R10980 T14823 T14821 arg1Of Decree,Belgian
R10981 T14823 T14822 arg1Of Decree,Royal
R10982 T14823 T14824 arg1Of Decree,06/04/2010
R10983 T14825 T14814 arg3Of ),(
R10984 T14826 T14811 arg2Of and,to
R10985 T14826 T14812 arg1Of and,the
R10986 T14827 T14828 arg1Of European,(
R10987 T14831 T14828 arg2Of 2010/63/EU,(
R10988 T14831 T14829 arg1Of 2010/63/EU,EU
R10989 T14831 T14830 arg1Of 2010/63/EU,Directives
R10990 T14831 T14832 arg1Of 2010/63/EU,","
R10991 T14833 T14832 arg2Of 86/609/EEG,","
R10992 T14834 T14828 arg3Of ),(
R10993 T14836 T14826 arg2Of regulations,and
R10994 T14836 T14827 arg1Of regulations,European
R10995 T14836 T14835 arg1Of regulations,animal
R10996 T14838 T14837 arg1Of protocols,Animal
R10997 T14838 T14839 arg1Of protocols,were
R10998 T14838 T14840 arg2Of protocols,approved
R10999 T14840 T14839 arg2Of approved,were
R11000 T14844 T14840 arg1Of committee,approved
R11001 T14844 T14841 arg2Of committee,by
R11002 T14844 T14842 arg1Of committee,the
R11003 T14844 T14843 arg1Of committee,ethics
R11004 T14844 T14845 arg1Of committee,of
R11005 T14847 T14845 arg2Of University,of
R11006 T14847 T14846 arg1Of University,Ghent
R11007 T14847 T14848 arg1Of University,(
R11008 T14851 T14848 arg2Of LA1400091,(
R11009 T14851 T14849 arg1Of LA1400091,permit
R11010 T14851 T14850 arg1Of LA1400091,number
R11011 T14851 T14852 arg1Of LA1400091,","
R11012 T14854 T14852 arg2Of ID,","
R11013 T14854 T14853 arg1Of ID,approval
R11014 T14854 T14855 arg1Of ID,2010/001
R11015 T14856 T14848 arg3Of ),(
R11016 T14858 T14857 arg1Of efforts,All
R11017 T14858 T14859 arg1Of efforts,were
R11018 T14858 T14860 arg2Of efforts,made
R11019 T14860 T14859 arg2Of made,were
R11020 T14860 T14861 modOf made,to
R11021 T14862 T14861 arg1Of ameliorate,to
R11022 T14863 T14862 arg2Of suffering,ameliorate
R11023 T14863 T14864 arg1Of suffering,of
R11024 T14865 T14864 arg2Of animals,of
R11025 T14866 T14867 arg1Of Mice,were
R11026 T14866 T14868 arg2Of Mice,anesthetized
R11027 T14868 T14867 arg2Of anesthetized,were
R11028 T14870 T14871 arg1Of intraperitoneal,(
R11029 T14872 T14871 arg2Of i.p.,(
R11030 T14873 T14871 arg3Of ),(
R11031 T14874 T14868 arg1Of injection,anesthetized
R11032 T14874 T14869 arg2Of injection,by
R11033 T14874 T14870 arg1Of injection,intraperitoneal
R11034 T14874 T14875 arg1Of injection,of
R11035 T14877 T14875 arg2Of mixture,of
R11036 T14877 T14876 arg1Of mixture,a
R11037 T14877 T14878 arg1Of mixture,of
R11038 T14879 T14880 arg1Of ketamine,(
R11039 T14879 T14884 arg1Of ketamine,and
R11040 T14882 T14880 arg2Of mg/kg,(
R11041 T14882 T14881 arg1Of mg/kg,12
R11042 T14883 T14880 arg3Of ),(
R11043 T14884 T14878 arg2Of and,of
R11044 T14885 T14884 arg2Of xylazine,and
R11045 T14885 T14886 arg1Of xylazine,(
R11046 T14888 T14886 arg2Of mg/kg,(
R11047 T14888 T14887 arg1Of mg/kg,60
R11048 T14889 T14886 arg3Of ),(
R11141 T15002 T15001 arg1Of mice,A20fl/fl
R11142 T15002 T15003 arg1Of mice,were
R11143 T15002 T15004 arg2Of mice,generated
R11144 T15004 T15003 arg2Of generated,were
R11145 T15004 T15005 arg1Of generated,as
R11146 T15007 T15006 arg1Of described,previously
R11147 T15009 T15005 arg2Of 56,as
R11148 T15009 T15007 arg1Of 56,described
R11149 T15009 T15008 arg2Of 56,[
R11150 T15010 T15008 arg3Of ],[
R11151 T15012 T15011 arg1Of mice,A20fl/fl
R11152 T15012 T15013 arg1Of mice,were
R11153 T15012 T15014 arg2Of mice,crossed
R11154 T15012 T15043 arg1Of mice,are
R11155 T15012 T15044 arg2Of mice,described
R11156 T15014 T15013 arg2Of crossed,were
R11157 T15014 T15015 arg1Of crossed,with
R11158 T15014 T15037 modOf crossed,to
R11159 T15014 T15042 arg1Of crossed,and
R11160 T15017 T15015 arg2Of mice,with
R11161 T15017 T15016 arg1Of mice,LysM-Cre
R11162 T15017 T15018 arg1Of mice,[
R11163 T15017 T15021 arg1Of mice,(
R11164 T15019 T15018 arg2Of 84,[
R11165 T15020 T15018 arg3Of ],[
R11166 T15022 T15021 arg2Of provided,(
R11167 T15025 T15024 arg1Of Förster,I.
R11168 T15025 T15026 arg1Of Förster,","
R11169 T15026 T15030 arg1Of ",",","
R11170 T15027 T15026 arg2Of Institute,","
R11171 T15027 T15028 arg1Of Institute,of
R11172 T15029 T15028 arg2Of Genetics,of
R11173 T15030 T15022 arg1Of ",",provided
R11174 T15030 T15023 arg2Of ",",by
R11175 T15030 T15034 arg1Of ",",","
R11176 T15031 T15030 arg2Of University,","
R11177 T15031 T15032 arg1Of University,of
R11178 T15033 T15032 arg2Of Cologne,of
R11179 T15035 T15034 arg2Of Germany,","
R11180 T15036 T15021 arg3Of ),(
R11181 T15038 T15037 arg1Of generate,to
R11182 T15041 T15038 arg2Of transgenes,generate
R11183 T15041 T15039 arg1Of transgenes,A20fl/fl
R11184 T15041 T15040 arg1Of transgenes,LysMCre
R11185 T15044 T15042 arg2Of described,and
R11186 T15044 T15043 arg2Of described,are
R11187 T15044 T15045 arg1Of described,in
R11188 T15044 T15048 arg1Of described,[
R11189 T15046 T15045 arg2Of detail,in
R11190 T15046 T15047 arg1Of detail,elsewhere
R11191 T15049 T15048 arg2Of 48,[
R11192 T15050 T15048 arg3Of ],[
R11193 T15051 T15052 arg1Of Mice,were
R11194 T15051 T15053 arg2Of Mice,housed
R11195 T15053 T15052 arg2Of housed,were
R11196 T15053 T15054 arg1Of housed,in
R11197 T15053 T15066 arg1Of housed,in
R11198 T15056 T15055 arg1Of ventilated,individually
R11199 T15057 T15054 arg2Of cages,in
R11200 T15057 T15056 arg1Of cages,ventilated
R11201 T15057 T15058 arg1Of cages,at
R11202 T15061 T15058 arg2Of Department,at
R11203 T15061 T15059 arg1Of Department,the
R11204 T15061 T15060 arg1Of Department,VIB
R11205 T15061 T15062 arg1Of Department,of
R11206 T15065 T15062 arg2Of Research,of
R11207 T15065 T15063 arg1Of Research,Molecular
R11208 T15065 T15064 arg1Of Research,Biomedical
R11209 T15070 T15066 arg2Of facilities,in
R11210 T15070 T15067 arg1Of facilities,specific
R11211 T15070 T15068 arg1Of facilities,pathogen-free
R11212 T15070 T15069 arg1Of facilities,animal
R11213 T15072 T15071 arg1Of infections,Influenza
R11214 T15072 T15073 arg1Of infections,were
R11215 T15072 T15074 arg2Of infections,performed
R11216 T15074 T15073 arg2Of performed,were
R11217 T15074 T15075 arg1Of performed,on
R11218 T15076 T15077 arg1Of age-,(
R11219 T15076 T15085 arg1Of age-,and
R11220 T15079 T15080 arg1Of 7,and
R11221 T15080 T15078 arg1Of and,between
R11222 T15081 T15080 arg2Of 9,and
R11223 T15082 T15077 arg2Of weeks,(
R11224 T15082 T15079 arg1Of weeks,7
R11225 T15082 T15081 arg1Of weeks,9
R11226 T15082 T15083 arg1Of weeks,old
R11227 T15084 T15077 arg3Of ),(
R11228 T15085 T15075 arg2Of and,on
R11229 T15087 T15085 arg2Of littermates,and
R11230 T15087 T15086 arg1Of littermates,sex-matched
R11231 T15090 T15088 arg1Of animals,A20fl/fl
R11232 T15090 T15089 arg1Of animals,LysM-Cre
R11233 T15090 T15091 arg1Of animals,were
R11234 T15090 T15092 arg2Of animals,backcrossed
R11235 T15092 T15091 arg2Of backcrossed,were
R11236 T15092 T15094 arg1Of backcrossed,times
R11237 T15092 T15095 arg1Of backcrossed,to
R11238 T15094 T15093 arg1Of times,three
R11239 T15098 T15095 arg2Of background,to
R11240 T15098 T15096 arg1Of background,the
R11241 T15098 T15097 arg1Of background,C57Bl/6
R11242 T15100 T15099 arg1Of mice,A20fl/fl
R11243 T15100 T15101 arg1Of mice,expressing
R11244 T15100 T15103 arg1Of mice,lacking
R11245 T15100 T15107 arg1Of mice,were
R11246 T15100 T15108 arg2Of mice,termed
R11247 T15101 T15102 arg1Of expressing,or
R11248 T15103 T15102 arg2Of lacking,or
R11249 T15106 T15101 arg2Of transgene,expressing
R11250 T15106 T15103 arg2Of transgene,lacking
R11251 T15106 T15104 arg1Of transgene,the
R11252 T15106 T15105 arg1Of transgene,LysM-Cre
R11253 T15108 T15107 arg2Of termed,were
R11254 T15108 T15116 arg1Of termed,respectively
R11255 T15109 T15110 arg1Of A20myel-KO,and
R11256 T15110 T15108 arg3Of and,termed
R11257 T15112 T15110 arg2Of type,and
R11258 T15112 T15111 arg1Of type,wild
R11259 T15112 T15113 arg1Of type,(
R11260 T15114 T15113 arg2Of A20myel-WT,(
R11261 T15115 T15113 arg3Of ),(
R11393 T15296 T15295 arg1Of infection,Viral
R11394 T15296 T15297 arg1Of infection,and
R11395 T15297 T15299 arg1Of and,of
R11396 T15298 T15297 arg2Of determination,and
R11397 T15301 T15299 arg2Of titers,of
R11398 T15301 T15300 arg1Of titers,viral
R11399 T15302 T15303 arg1Of Mouse,adapted
R11400 T15305 T15304 arg1Of X-47,IAV
R11401 T15305 T15306 arg1Of X-47,(
R11402 T15305 T15311 arg1Of X-47,was
R11403 T15305 T15312 arg2Of X-47,propagated
R11404 T15307 T15306 arg2Of H3N2,(
R11405 T15307 T15308 arg1Of H3N2,;
R11406 T15309 T15308 arg2Of PR8×A/Victoria/3/75,;
R11407 T15310 T15306 arg3Of ),(
R11408 T15312 T15303 arg2Of propagated,adapted
R11409 T15312 T15311 arg2Of propagated,was
R11410 T15312 T15313 arg1Of propagated,in
R11411 T15315 T15313 arg2Of cells,in
R11412 T15315 T15314 arg1Of cells,MDCK
R11413 T15318 T15316 arg2Of inoculation,For
R11414 T15318 T15317 arg1Of inoculation,viral
R11415 T15320 T15321 arg1Of mice,were
R11416 T15320 T15322 arg2Of mice,anesthetized
R11417 T15322 T15316 arg1Of anesthetized,For
R11418 T15322 T15319 arg1Of anesthetized,","
R11419 T15322 T15321 arg2Of anesthetized,were
R11420 T15325 T15322 arg1Of injection,anesthetized
R11421 T15325 T15323 arg2Of injection,by
R11422 T15325 T15324 arg1Of injection,i.p.
R11423 T15325 T15326 arg1Of injection,with
R11424 T15327 T15328 arg1Of ketamine,(
R11425 T15327 T15332 arg1Of ketamine,and
R11426 T15330 T15328 arg2Of mg/kg,(
R11427 T15330 T15329 arg1Of mg/kg,12
R11428 T15331 T15328 arg3Of ),(
R11429 T15332 T15338 arg1Of and,and
R11430 T15333 T15332 arg2Of xylazine,and
R11431 T15333 T15334 arg1Of xylazine,(
R11432 T15336 T15334 arg2Of mg/kg,(
R11433 T15336 T15335 arg1Of mg/kg,60
R11434 T15337 T15334 arg3Of ),(
R11435 T15338 T15326 arg2Of and,with
R11436 T15341 T15338 arg2Of X-47,and
R11437 T15341 T15339 arg1Of X-47,50
R11438 T15341 T15340 arg1Of X-47,µl
R11439 T15341 T15342 arg2Of X-47,diluted
R11440 T15342 T15343 arg1Of diluted,in
R11441 T15344 T15345 arg1Of PBS,was
R11442 T15344 T15346 arg2Of PBS,administered
R11443 T15346 T15343 arg2Of administered,in
R11444 T15346 T15345 arg2Of administered,was
R11445 T15346 T15347 arg1Of administered,intranasally
R11446 T15349 T15350 arg1Of lethal,and
R11447 T15351 T15350 arg2Of sublethal,and
R11448 T15352 T15348 arg2Of infection,For
R11449 T15352 T15349 arg1Of infection,lethal
R11450 T15352 T15351 arg1Of infection,sublethal
R11451 T15354 T15355 arg1Of mice,received
R11452 T15355 T15348 arg1Of received,For
R11453 T15355 T15353 arg1Of received,","
R11454 T15355 T15356 arg1Of received,respectively
R11455 T15357 T15358 arg1Of 2-LD50,or
R11456 T15358 T15355 arg2Of or,received
R11457 T15360 T15358 arg2Of X-47,or
R11458 T15360 T15359 arg1Of X-47,0.05-LD50
R11459 T15362 T15361 arg1Of determine,To
R11460 T15365 T15362 arg2Of titers,determine
R11461 T15365 T15363 arg1Of titers,pulmonary
R11462 T15365 T15364 arg1Of titers,viral
R11463 T15371 T15362 arg1Of dose,determine
R11464 T15371 T15367 arg1Of dose,median
R11465 T15371 T15368 arg1Of dose,tissue
R11466 T15371 T15369 arg1Of dose,culture
R11467 T15371 T15370 arg1Of dose,infectious
R11468 T15371 T15372 arg1Of dose,(
R11469 T15371 T15375 arg1Of dose,was
R11470 T15371 T15376 arg2Of dose,measured
R11471 T15371 T15378 arg1Of dose,follows
R11472 T15373 T15372 arg2Of TCID50,(
R11473 T15374 T15372 arg3Of ),(
R11474 T15376 T15375 arg2Of measured,was
R11475 T15376 T15377 arg1Of measured,as
R11476 T15377 T15361 modOf as,To
R11477 T15377 T15366 arg1Of as,","
R11478 T15378 T15377 arg2Of follows,as
R11479 T15378 T15379 arg1Of follows,:
R11480 T15380 T15381 arg1Of lungs,were
R11481 T15380 T15382 arg2Of lungs,homogenized
R11482 T15382 T15379 arg2Of homogenized,:
R11483 T15382 T15381 arg2Of homogenized,were
R11484 T15382 T15383 arg1Of homogenized,with
R11485 T15386 T15383 arg2Of homogenizer,with
R11486 T15386 T15384 arg1Of homogenizer,a
R11487 T15386 T15385 arg1Of homogenizer,Polytron
R11488 T15386 T15387 arg1Of homogenizer,(
R11489 T15386 T15390 arg1Of homogenizer,in
R11490 T15388 T15387 arg2Of Kinematica,(
R11491 T15389 T15387 arg3Of ),(
R11492 T15391 T15390 arg2Of PBS,in
R11493 T15394 T15392 arg1Of dilutions,Eight-fold
R11494 T15394 T15393 arg1Of dilutions,serial
R11495 T15394 T15395 arg1Of dilutions,of
R11496 T15394 T15398 arg1Of dilutions,were
R11497 T15394 T15399 arg2Of dilutions,incubated
R11498 T15397 T15395 arg2Of homogenates,of
R11499 T15397 T15396 arg1Of homogenates,lung
R11500 T15399 T15398 arg2Of incubated,were
R11501 T15399 T15400 arg1Of incubated,on
R11502 T15402 T15400 arg2Of cells,on
R11503 T15402 T15401 arg1Of cells,MDCK
R11504 T15402 T15403 arg1Of cells,for
R11505 T15405 T15403 arg2Of days,for
R11506 T15405 T15404 arg1Of days,5
R11507 T15405 T15406 arg1Of days,in
R11508 T15405 T15408 arg2Of days,supplemented
R11509 T15407 T15406 arg2Of DMEM,in
R11510 T15408 T15409 arg1Of supplemented,with
R11511 T15410 T15411 arg1Of trypsin,(
R11512 T15410 T15415 arg1Of trypsin,","
R11513 T15413 T15411 arg2Of µg/ml,(
R11514 T15413 T15412 arg1Of µg/ml,1
R11515 T15414 T15411 arg3Of ),(
R11516 T15415 T15419 arg1Of ",",","
R11517 T15416 T15417 arg1Of 2,mM
R11518 T15418 T15415 arg2Of L-glutamine,","
R11519 T15418 T15416 arg1Of L-glutamine,2
R11520 T15419 T15424 arg1Of ",",and
R11521 T15420 T15421 arg1Of 0.4,mM
R11522 T15423 T15419 arg2Of pyruvate,","
R11523 T15423 T15420 arg1Of pyruvate,0.4
R11524 T15423 T15422 arg1Of pyruvate,sodium
R11525 T15424 T15409 arg2Of and,with
R11526 T15425 T15424 arg2Of antibiotics,and
R11527 T15427 T15426 arg2Of read-out,For
R11528 T15429 T15430 arg1Of 0.5,%
R11529 T15434 T15429 arg1Of cells,0.5
R11530 T15434 T15431 arg1Of cells,chicken
R11531 T15434 T15432 arg1Of cells,red
R11532 T15434 T15433 arg1Of cells,blood
R11533 T15434 T15435 arg1Of cells,(
R11534 T15434 T15438 arg1Of cells,were
R11535 T15434 T15439 arg2Of cells,added
R11536 T15436 T15435 arg2Of RBC,(
R11537 T15437 T15435 arg3Of ),(
R11538 T15439 T15438 arg2Of added,were
R11539 T15439 T15440 arg1Of added,and
R11540 T15440 T15426 arg1Of and,For
R11541 T15440 T15428 arg1Of and,","
R11542 T15442 T15441 arg1Of dilution,end-point
R11543 T15442 T15443 arg1Of dilution,of
R11544 T15442 T15445 arg1Of dilution,was
R11545 T15442 T15446 arg2Of dilution,monitored
R11546 T15444 T15443 arg2Of hemagglutination,of
R11547 T15446 T15440 arg2Of monitored,and
R11548 T15446 T15445 arg2Of monitored,was
R11549 T15448 T15447 arg1Of titers,TCID50
R11550 T15448 T15449 arg1Of titers,were
R11551 T15448 T15451 arg2Of titers,calculated
R11552 T15451 T15449 arg2Of calculated,were
R11553 T15451 T15450 arg1Of calculated,then
R11554 T15451 T15452 arg1Of calculated,according
R11555 T15453 T15452 arg2Of to,according
R11556 T15455 T15453 arg2Of method,to
R11557 T15455 T15454 arg1Of method,the
R11558 T15455 T15456 arg1Of method,of
R11559 T15457 T15458 arg1Of Reed,and
R11560 T15458 T15456 arg2Of and,of
R11561 T15459 T15458 arg2Of Muench,and
R11562 T15459 T15460 arg1Of Muench,[
R11563 T15461 T15460 arg2Of 85,[
R11564 T15462 T15460 arg3Of ],[
R11746 T15676 T15677 arg1Of Determination,of
R11747 T15676 T15679 arg1Of Determination,(
R11748 T15678 T15677 arg2Of HAI,of
R11749 T15681 T15679 arg2Of inhibition,(
R11750 T15681 T15680 arg1Of inhibition,hemagglutination
R11751 T15682 T15679 arg3Of ),(
R11752 T15683 T15676 arg1Of titers,Determination
R11753 T15685 T15684 arg1Of determine,To
R11754 T15688 T15685 arg2Of titers,determine
R11755 T15688 T15686 arg1Of titers,the
R11756 T15688 T15687 arg1Of titers,HAI
R11757 T15688 T15689 arg1Of titers,in
R11758 T15691 T15689 arg2Of mice,in
R11759 T15691 T15690 arg1Of mice,infected
R11760 T15693 T15694 arg1Of sera,of
R11761 T15693 T15696 arg1Of sera,were
R11762 T15693 T15697 arg2Of sera,treated
R11763 T15693 T15708 arg1Of sera,remove
R11764 T15695 T15694 arg2Of these,of
R11765 T15697 T15684 modOf treated,To
R11766 T15697 T15692 arg1Of treated,","
R11767 T15697 T15696 arg2Of treated,were
R11768 T15697 T15698 arg1Of treated,with
R11769 T15697 T15707 modOf treated,to
R11770 T15700 T15698 arg2Of enzyme,with
R11771 T15700 T15699 arg1Of enzyme,receptor-destroying
R11772 T15700 T15701 arg1Of enzyme,(
R11773 T15703 T15701 arg2Of filtrate,(
R11774 T15703 T15702 arg1Of filtrate,RDE/Cholera
R11775 T15703 T15704 arg1Of filtrate,;
R11776 T15705 T15704 arg2Of Sigma,;
R11777 T15706 T15701 arg3Of ),(
R11778 T15708 T15707 arg1Of remove,to
R11779 T15710 T15708 arg2Of acids,remove
R11780 T15710 T15709 arg1Of acids,sialic
R11781 T15710 T15711 arg1Of acids,from
R11782 T15713 T15711 arg2Of proteins,from
R11783 T15713 T15712 arg1Of proteins,serum
R11784 T15713 T15714 arg1Of proteins,capable
R11785 T15714 T15715 arg1Of capable,of
R11786 T15717 T15715 arg2Of inhibition,of
R11787 T15717 T15716 arg1Of inhibition,aspecific
R11788 T15717 T15718 arg1Of inhibition,of
R11789 T15719 T15718 arg2Of agglutination,of
R11790 T15721 T15720 arg2Of incubation,After
R11791 T15721 T15723 arg1Of incubation,at
R11792 T15723 T15722 arg1Of at,overnight
R11793 T15724 T15723 arg2Of 37°C,at
R11794 T15727 T15726 arg1Of RDE,the
R11795 T15727 T15728 arg1Of RDE,was
R11796 T15727 T15729 arg2Of RDE,inactivated
R11797 T15729 T15720 arg1Of inactivated,After
R11798 T15729 T15725 arg1Of inactivated,","
R11799 T15729 T15728 arg2Of inactivated,was
R11800 T15731 T15729 arg1Of addition,inactivated
R11801 T15731 T15730 arg2Of addition,by
R11802 T15731 T15732 arg1Of addition,of
R11803 T15736 T15733 arg1Of citrate,0.75
R11804 T15736 T15734 arg1Of citrate,%
R11805 T15736 T15735 arg1Of citrate,sodium
R11806 T15736 T15737 arg1Of citrate,in
R11807 T15736 T15739 arg1Of citrate,and
R11808 T15738 T15737 arg2Of PBS,in
R11809 T15739 T15732 arg2Of and,of
R11810 T15740 T15739 arg2Of heating,and
R11811 T15740 T15741 arg1Of heating,to
R11812 T15742 T15741 arg2Of 56°C,to
R11813 T15742 T15743 arg1Of 56°C,for
R11814 T15745 T15743 arg2Of min,for
R11815 T15745 T15744 arg1Of min,30
R11816 T15747 T15746 arg1Of remove,To
R11817 T15751 T15747 arg2Of proteins,remove
R11818 T15751 T15748 arg1Of proteins,sialic
R11819 T15751 T15749 arg1Of proteins,acid
R11820 T15751 T15750 arg1Of proteins,binding
R11821 T15753 T15747 arg1Of sera,remove
R11822 T15753 T15754 arg1Of sera,were
R11823 T15753 T15755 arg2Of sera,cleared
R11824 T15755 T15746 modOf cleared,To
R11825 T15755 T15752 arg1Of cleared,","
R11826 T15755 T15754 arg2Of cleared,were
R11827 T15755 T15756 arg1Of cleared,with
R11828 T15759 T15760 arg1Of 50,%
R11829 T15762 T15756 arg2Of RBC,with
R11830 T15762 T15757 arg1Of RBC,1/10
R11831 T15762 T15758 arg1Of RBC,volume
R11832 T15762 T15759 arg1Of RBC,50
R11833 T15762 T15761 arg1Of RBC,chicken
R11834 T15763 T15764 arg1Of Titration,was
R11835 T15763 T15765 arg2Of Titration,done
R11836 T15765 T15764 arg2Of done,was
R11837 T15765 T15766 arg1Of done,by
R11838 T15767 T15766 arg2Of incubating,by
R11839 T15767 T15781 arg1Of incubating,for
R11840 T15771 T15767 arg2Of series,incubating
R11841 T15771 T15768 arg1Of series,a
R11842 T15771 T15769 arg1Of series,two-fold
R11843 T15771 T15770 arg1Of series,dilution
R11844 T15771 T15772 arg1Of series,of
R11845 T15771 T15774 arg1Of series,with
R11846 T15773 T15772 arg2Of sera,of
R11847 T15777 T15774 arg2Of units,with
R11848 T15777 T15775 arg1Of units,4
R11849 T15777 T15776 arg1Of units,HA
R11850 T15777 T15778 arg1Of units,of
R11851 T15780 T15778 arg2Of virus,of
R11852 T15780 T15779 arg1Of virus,X-47
R11853 T15783 T15781 arg2Of hour,for
R11854 T15783 T15782 arg1Of hour,1
R11855 T15783 T15784 arg1Of hour,at
R11856 T15786 T15784 arg2Of temperature,at
R11857 T15786 T15785 arg1Of temperature,room
R11858 T15786 T15787 arg1Of temperature,in
R11859 T15790 T15787 arg2Of plates,in
R11860 T15790 T15788 arg1Of plates,96-well
R11861 T15790 T15789 arg1Of plates,U-bottom
R11862 T15795 T15793 arg1Of volume,an
R11863 T15795 T15794 arg1Of volume,equal
R11864 T15795 T15796 arg1Of volume,of
R11865 T15795 T15801 arg1Of volume,was
R11866 T15795 T15802 arg2Of volume,added
R11867 T15797 T15798 arg1Of 0.5,%
R11868 T15800 T15796 arg2Of RBC,of
R11869 T15800 T15797 arg1Of RBC,0.5
R11870 T15800 T15799 arg1Of RBC,chicken
R11871 T15802 T15801 arg2Of added,was
R11872 T15802 T15803 arg1Of added,and
R11873 T15803 T15791 arg1Of and,Finally
R11874 T15803 T15792 arg1Of and,","
R11875 T15804 T15805 arg1Of titers,were
R11876 T15804 T15806 arg2Of titers,read
R11877 T15806 T15803 arg2Of read,and
R11878 T15806 T15805 arg2Of read,were
R11879 T15806 T15809 arg1Of read,later
R11880 T15808 T15806 arg3Of min,read
R11881 T15808 T15807 arg1Of min,30
R11882 T15811 T15810 arg1Of controls,Negative
R11883 T15811 T15812 arg1Of controls,included
R11884 T15812 T15836 arg1Of included,;
R11885 T15813 T15815 arg1Of PBS,of
R11886 T15815 T15812 arg2Of of,included
R11887 T15815 T15814 arg1Of of,instead
R11888 T15815 T15828 arg1Of of,(
R11889 T15817 T15816 arg1Of serum,immune
R11890 T15817 T15818 arg1Of serum,(
R11891 T15817 T15822 arg1Of serum,or
R11892 T15820 T15818 arg2Of control,(
R11893 T15820 T15819 arg1Of control,agglutination
R11894 T15821 T15818 arg3Of ),(
R11895 T15822 T15815 arg2Of or,of
R11896 T15823 T15825 arg1Of PR8,of
R11897 T15825 T15822 arg2Of of,or
R11898 T15825 T15824 arg1Of of,instead
R11899 T15827 T15825 arg2Of virus,of
R11900 T15827 T15826 arg1Of virus,X-47
R11901 T15829 T15828 arg2Of control,(
R11902 T15829 T15830 arg1Of control,for
R11903 T15832 T15830 arg2Of effect,for
R11904 T15832 T15831 arg1Of effect,agglutination
R11905 T15832 T15833 arg1Of effect,of
R11906 T15834 T15833 arg2Of sera,of
R11907 T15835 T15828 arg3Of ),(
R11908 T15839 T15837 arg2Of control,as
R11909 T15839 T15838 arg1Of control,positive
R11910 T15841 T15842 arg1Of serum,from
R11911 T15841 T15853 arg1Of serum,was
R11912 T15841 T15854 arg2Of serum,used
R11913 T15844 T15842 arg2Of mouse,from
R11914 T15844 T15843 arg1Of mouse,a
R11915 T15844 T15845 arg2Of mouse,infected
R11916 T15845 T15846 arg1Of infected,twice
R11917 T15845 T15847 arg1Of infected,with
R11918 T15850 T15847 arg2Of dose,with
R11919 T15850 T15848 arg1Of dose,a
R11920 T15850 T15849 arg1Of dose,sublethal
R11921 T15850 T15851 arg1Of dose,of
R11922 T15852 T15851 arg2Of X-47,of
R11923 T15854 T15836 arg2Of used,;
R11924 T15854 T15837 arg1Of used,as
R11925 T15854 T15840 arg1Of used,","
R11926 T15854 T15853 arg2Of used,was
R12129 T16147 T16146 arg1Of vivo,In
R12130 T16149 T16150 arg1Of GrB,and
R12131 T16151 T16150 arg2Of IFNγ,and
R12132 T16152 T16147 arg1Of staining,vivo
R12133 T16152 T16148 arg1Of staining,intracellular
R12134 T16152 T16149 arg1Of staining,GrB
R12135 T16152 T16151 arg1Of staining,IFNγ
R12136 T16152 T16153 arg1Of staining,of
R12137 T16157 T16153 arg2Of cells,of
R12138 T16157 T16154 arg2Of cells,activated
R12139 T16157 T16155 arg1Of cells,CD8+
R12140 T16157 T16156 arg1Of cells,T
R12141 T16159 T16158 arg1Of B,Granzyme
R12142 T16159 T16160 arg1Of B,(
R12143 T16159 T16163 arg1Of B,and
R12144 T16161 T16160 arg2Of GrB,(
R12145 T16162 T16160 arg3Of ),(
R12146 T16163 T16169 arg1Of and,were
R12147 T16163 T16170 arg2Of and,determined
R12148 T16164 T16163 arg2Of IFNγ,and
R12149 T16164 T16165 arg1Of IFNγ,expressing
R12150 T16168 T16165 arg2Of cells,expressing
R12151 T16168 T16166 arg1Of cells,CD8+
R12152 T16168 T16167 arg1Of cells,T
R12153 T16170 T16169 arg2Of determined,were
R12154 T16170 T16171 arg1Of determined,by
R12155 T16172 T16171 arg2Of treating,by
R12156 T16172 T16175 arg1Of treating,intranasally
R12157 T16172 T16176 arg1Of treating,with
R12158 T16174 T16172 arg2Of mice,treating
R12159 T16174 T16173 arg1Of mice,the
R12160 T16180 T16176 arg2Of A,with
R12161 T16180 T16177 arg1Of A,50
R12162 T16180 T16178 arg1Of A,µg
R12163 T16180 T16179 arg1Of A,Brefeldin
R12164 T16180 T16181 arg1Of A,(
R12165 T16180 T16184 arg1Of A,as
R12166 T16182 T16181 arg2Of Sigma,(
R12167 T16183 T16181 arg3Of ),(
R12168 T16186 T16185 arg1Of described,previously
R12169 T16188 T16184 arg2Of 86,as
R12170 T16188 T16186 arg1Of 86,described
R12171 T16188 T16187 arg2Of 86,[
R12172 T16189 T16187 arg3Of ],[
R12173 T16191 T16190 arg1Of h,6
R12174 T16194 T16195 arg1Of BAL,and
R12175 T16195 T16197 arg1Of and,were
R12176 T16195 T16198 arg2Of and,isolated
R12177 T16195 T16217 arg1Of and,were
R12178 T16195 T16218 arg2Of and,stained
R12179 T16195 T16220 arg2Of and,fixed
R12180 T16195 T16222 arg2Of and,permeabilized
R12181 T16196 T16195 arg2Of lungs,and
R12182 T16198 T16197 arg2Of isolated,were
R12183 T16198 T16199 arg1Of isolated,and
R12184 T16199 T16191 arg1Of and,h
R12185 T16199 T16192 arg1Of and,later
R12186 T16199 T16193 arg1Of and,","
R12187 T16202 T16200 arg1Of suspensions,single
R12188 T16202 T16201 arg1Of suspensions,cell
R12189 T16202 T16203 arg1Of suspensions,were
R12190 T16202 T16204 arg2Of suspensions,prepared
R12191 T16204 T16203 arg2Of prepared,were
R12192 T16204 T16205 arg1Of prepared,from
R12193 T16204 T16208 arg1Of prepared,in
R12194 T16207 T16205 arg2Of lung,from
R12195 T16207 T16206 arg1Of lung,the
R12196 T16210 T16208 arg2Of presence,in
R12197 T16210 T16209 arg1Of presence,the
R12198 T16210 T16211 arg1Of presence,of
R12199 T16216 T16211 arg2Of Cells,of
R12200 T16216 T16212 arg1Of Cells,3
R12201 T16216 T16213 arg1Of Cells,µg/ml
R12202 T16216 T16214 arg1Of Cells,Brefeldin
R12203 T16216 T16215 arg1Of Cells,A.
R12204 T16218 T16219 arg1Of stained,","
R12205 T16219 T16221 arg1Of ",",and
R12206 T16220 T16219 arg2Of fixed,","
R12207 T16221 T16199 arg2Of and,and
R12208 T16221 T16203 modOf and,were
R12209 T16221 T16217 arg2Of and,were
R12210 T16221 T16223 arg1Of and,(
R12211 T16221 T16229 arg1Of and,according
R12212 T16222 T16221 arg2Of permeabilized,and
R12213 T16224 T16223 arg2Of Cytofix/Cytoperm,(
R12214 T16224 T16225 arg1Of Cytofix/Cytoperm,","
R12215 T16227 T16225 arg2Of Biosciences,","
R12216 T16227 T16226 arg1Of Biosciences,BD
R12217 T16228 T16223 arg3Of ),(
R12218 T16230 T16229 arg2Of to,according
R12219 T16232 T16231 arg1Of manufacturer,the
R12220 T16232 T16233 arg2Of manufacturer,'s
R12221 T16234 T16230 arg2Of instructions,to
R12222 T16234 T16233 arg1Of instructions,'s
R12223 T16238 T16235 arg2Of cells,Activated
R12224 T16238 T16236 arg1Of cells,CD8+
R12225 T16238 T16237 arg1Of cells,T
R12226 T16238 T16239 arg1Of cells,were
R12227 T16238 T16240 arg2Of cells,analyzed
R12228 T16240 T16239 arg2Of analyzed,were
R12229 T16243 T16240 arg1Of cytometry,analyzed
R12230 T16243 T16241 arg2Of cytometry,by
R12231 T16243 T16242 arg1Of cytometry,flow
R12232 T16243 T16244 arg2Of cytometry,based
R12233 T16244 T16245 arg1Of based,on
R12234 T16247 T16248 arg1Of CD3+,and
R12235 T16249 T16248 arg2Of CD8+,and
R12236 T16250 T16245 arg2Of expression,on
R12237 T16250 T16246 arg1Of expression,CD62lo
R12238 T16250 T16247 arg1Of expression,CD3+
R12239 T16250 T16249 arg1Of expression,CD8+
R12240 T16257 T16251 arg1Of kit,Live/Dead
R12241 T16257 T16252 arg1Of kit,fixable
R12242 T16257 T16253 arg1Of kit,aqua
R12243 T16257 T16254 arg1Of kit,dead
R12244 T16257 T16255 arg1Of kit,cell
R12245 T16257 T16256 arg1Of kit,stain
R12246 T16257 T16258 arg1Of kit,(
R12247 T16257 T16262 arg1Of kit,was
R12248 T16257 T16263 arg2Of kit,used
R12249 T16257 T16265 arg1Of kit,discriminate
R12250 T16257 T16266 arg1Of kit,live
R12251 T16260 T16258 arg2Of Probes,(
R12252 T16260 T16259 arg1Of Probes,Molecular
R12253 T16261 T16258 arg3Of ),(
R12254 T16263 T16262 arg2Of used,was
R12255 T16265 T16263 arg3Of discriminate,used
R12256 T16265 T16264 arg1Of discriminate,to
R12257 T16266 T16265 arg2Of live,discriminate
R12258 T16266 T16267 arg1Of live,from
R12259 T16269 T16267 arg2Of cells,from
R12260 T16269 T16268 arg1Of cells,dead
R12424 T16567 T16568 arg1Of Cells,and
R12425 T16569 T16568 arg2Of transfection,and
R12426 T16570 T16571 arg1Of HEK293T,and
R12427 T16572 T16571 arg2Of MDCK,and
R12428 T16573 T16570 arg1Of cells,HEK293T
R12429 T16573 T16572 arg1Of cells,MDCK
R12430 T16573 T16574 arg1Of cells,were
R12431 T16573 T16575 arg2Of cells,grown
R12432 T16575 T16574 arg2Of grown,were
R12433 T16575 T16576 arg1Of grown,in
R12434 T16577 T16576 arg2Of DMEM,in
R12435 T16577 T16578 arg1Of DMEM,(
R12436 T16577 T16581 arg2Of DMEM,supplemented
R12437 T16579 T16578 arg2Of Gibco,(
R12438 T16580 T16578 arg3Of ),(
R12439 T16581 T16582 arg1Of supplemented,with
R12440 T16583 T16584 arg1Of 10,%
R12441 T16585 T16583 arg1Of FCS,10
R12442 T16585 T16586 arg1Of FCS,","
R12443 T16586 T16590 arg1Of ",",","
R12444 T16587 T16588 arg1Of 2,mM
R12445 T16589 T16586 arg2Of L-glutamine,","
R12446 T16589 T16587 arg1Of L-glutamine,2
R12447 T16590 T16595 arg1Of ",",and
R12448 T16591 T16592 arg1Of 0.4,mM
R12449 T16594 T16590 arg2Of pyruvate,","
R12450 T16594 T16591 arg1Of pyruvate,0.4
R12451 T16594 T16593 arg1Of pyruvate,sodium
R12452 T16595 T16582 arg2Of and,with
R12453 T16596 T16595 arg2Of antibiotics,and
R12454 T16598 T16597 arg1Of cells,HEK293T
R12455 T16598 T16599 arg1Of cells,were
R12456 T16598 T16600 arg2Of cells,transfected
R12457 T16600 T16599 arg2Of transfected,were
R12458 T16600 T16601 modOf transfected,using
R12459 T16604 T16601 arg2Of phosphate,using
R12460 T16604 T16602 arg1Of phosphate,the
R12461 T16604 T16603 arg1Of phosphate,calcium
R12462 T16607 T16605 arg2Of method,precipitate
R12463 T16607 T16606 arg1Of method,transfection
R12464 T16607 T16608 arg1Of method,with
R12465 T16611 T16608 arg2Of vectors,with
R12466 T16611 T16609 arg1Of vectors,specific
R12467 T16611 T16610 arg1Of vectors,expression
R12468 T16613 T16614 arg1Of pCAGGS-E-hA20,(
R12469 T16613 T16618 arg1Of pCAGGS-E-hA20,","
R12470 T16615 T16614 arg2Of LMBP,(
R12471 T16615 T16616 arg1Of LMBP,3778
R12472 T16617 T16614 arg3Of ),(
R12473 T16618 T16624 arg1Of ",",","
R12474 T16619 T16618 arg2Of pCAGGS-E-RIG-I-CARD,","
R12475 T16619 T16620 arg1Of pCAGGS-E-RIG-I-CARD,(
R12476 T16621 T16620 arg2Of LMBP,(
R12477 T16621 T16622 arg1Of LMBP,6517
R12478 T16623 T16620 arg3Of ),(
R12479 T16624 T16612 arg2Of ",",(
R12480 T16625 T16624 arg2Of pEF-HA-IRF-7,","
R12481 T16628 T16627 arg1Of provided,kindly
R12482 T16631 T16630 arg1Of Taniguchi,T.
R12483 T16631 T16632 arg1Of Taniguchi,","
R12484 T16632 T16637 arg1Of ",",and
R12485 T16634 T16632 arg2Of School,","
R12486 T16634 T16633 arg1Of School,Graduate
R12487 T16634 T16635 arg1Of School,of
R12488 T16636 T16635 arg2Of Medicine,of
R12489 T16637 T16628 arg1Of and,provided
R12490 T16637 T16629 arg2Of and,by
R12491 T16638 T16637 arg2Of Faculty,and
R12492 T16638 T16639 arg1Of Faculty,of
R12493 T16640 T16639 arg2Of Medicine,of
R12494 T16642 T16641 arg2Of University,","
R12495 T16642 T16643 arg1Of University,of
R12496 T16644 T16643 arg2Of Tokyo,of
R12497 T16648 T16649 arg1Of NF-κB,","
R12498 T16649 T16651 arg1Of ",",","
R12499 T16650 T16649 arg2Of IRF3,","
R12500 T16654 T16651 arg2Of plasmids,","
R12501 T16654 T16652 arg1Of plasmids,IRF7
R12502 T16654 T16653 arg1Of plasmids,reporter
R12503 T16657 T16658 arg1Of pConLuc,(
R12504 T16657 T16661 arg1Of pConLuc,","
R12505 T16659 T16658 arg2Of LMBP3248,(
R12506 T16660 T16658 arg3Of ),(
R12507 T16661 T16655 arg2Of ",",(
R12508 T16661 T16656 arg1Of ",",respectively
R12509 T16661 T16666 arg1Of ",",","
R12510 T16662 T16661 arg2Of pISRE-luc,","
R12511 T16662 T16663 arg1Of pISRE-luc,(
R12512 T16664 T16663 arg2Of LMBP4011,(
R12513 T16665 T16663 arg3Of ),(
R12514 T16667 T16668 arg1Of pGL3-IFNα4-luc,(
R12515 T16667 T16685 arg1Of pGL3-IFNα4-luc,and
R12516 T16670 T16668 arg2Of provided,(
R12517 T16670 T16669 arg1Of provided,kindly
R12518 T16673 T16672 arg1Of Hiscott,J.
R12519 T16673 T16674 arg1Of Hiscott,","
R12520 T16674 T16677 arg1Of ",",","
R12521 T16676 T16674 arg2Of University,","
R12522 T16676 T16675 arg1Of University,McGill
R12523 T16677 T16679 arg1Of ",",","
R12524 T16678 T16677 arg2Of Montreal,","
R12525 T16679 T16670 arg1Of ",",provided
R12526 T16679 T16671 arg2Of ",",by
R12527 T16679 T16681 arg1Of ",",","
R12528 T16680 T16679 arg2Of Quebec,","
R12529 T16682 T16681 arg2Of Canada,","
R12530 T16683 T16668 arg3Of ),(
R12531 T16685 T16666 arg2Of and,","
R12532 T16685 T16684 arg1Of and,","
R12533 T16686 T16685 arg2Of pACTbetagal,and
R12534 T16686 T16687 arg1Of pACTbetagal,(
R12535 T16688 T16687 arg2Of LMBP4341,(
R12536 T16689 T16687 arg3Of ),(
R12537 T16693 T16690 arg2Of normalization,for
R12538 T16693 T16691 arg1Of normalization,transfection
R12539 T16693 T16692 arg1Of normalization,efficiency
R12540 T16694 T16695 arg1Of Details,of
R12541 T16694 T16697 arg1Of Details,are
R12542 T16694 T16698 arg2Of Details,presented
R12543 T16696 T16695 arg2Of plasmids,of
R12544 T16698 T16697 arg2Of presented,are
R12545 T16698 T16699 arg1Of presented,along
R12546 T16698 T16704 arg1Of presented,at
R12547 T16698 T16710 arg1Of presented,:
R12548 T16698 T16711 arg1Of presented,//bccm.belspo.be/index.php
R12549 T16699 T16700 arg1Of along,with
R12550 T16703 T16700 arg2Of maps,with
R12551 T16703 T16701 arg1Of maps,detailed
R12552 T16703 T16702 arg1Of maps,sequence
R12553 T16709 T16704 arg2Of http,at
R12554 T16709 T16705 arg1Of http,the
R12555 T16709 T16706 arg1Of http,BCCM-LMBP
R12556 T16709 T16707 arg1Of http,plasmid
R12557 T16709 T16708 arg1Of http,databank
R12558 T16714 T16712 arg2Of generation,For
R12559 T16714 T16713 arg1Of generation,the
R12560 T16714 T16715 arg1Of generation,of
R12561 T16716 T16715 arg2Of BMDM,of
R12562 T16720 T16718 arg1Of cells,bone
R12563 T16720 T16719 arg1Of cells,marrow
R12564 T16720 T16721 arg1Of cells,were
R12565 T16720 T16722 arg2Of cells,cultured
R12566 T16722 T16712 arg1Of cultured,For
R12567 T16722 T16717 arg1Of cultured,","
R12568 T16722 T16721 arg2Of cultured,were
R12569 T16722 T16724 arg1Of cultured,days
R12570 T16724 T16723 arg1Of days,7
R12571 T16724 T16725 arg1Of days,in
R12572 T16724 T16731 arg2Of days,supplemented
R12573 T16726 T16725 arg2Of RPMI,in
R12574 T16726 T16727 arg1Of RPMI,1640
R12575 T16726 T16728 arg1Of RPMI,(
R12576 T16729 T16728 arg2Of Gibco,(
R12577 T16730 T16728 arg3Of ),(
R12578 T16731 T16732 arg1Of supplemented,with
R12579 T16733 T16734 arg1Of 10,%
R12580 T16735 T16733 arg1Of FCS,10
R12581 T16735 T16736 arg1Of FCS,","
R12582 T16736 T16740 arg1Of ",",","
R12583 T16737 T16738 arg1Of 2,mM
R12584 T16739 T16736 arg2Of L-glutamine,","
R12585 T16739 T16737 arg1Of L-glutamine,2
R12586 T16740 T16745 arg1Of ",",","
R12587 T16741 T16742 arg1Of 0.4,mM
R12588 T16744 T16740 arg2Of pyruvate,","
R12589 T16744 T16741 arg1Of pyruvate,0.4
R12590 T16744 T16743 arg1Of pyruvate,sodium
R12591 T16745 T16747 arg1Of ",",and
R12592 T16746 T16745 arg2Of antibiotics,","
R12593 T16747 T16732 arg2Of and,with
R12594 T16751 T16747 arg2Of M-CSF,and
R12595 T16751 T16748 arg1Of M-CSF,40
R12596 T16751 T16749 arg1Of M-CSF,ng/ml
R12597 T16751 T16750 arg1Of M-CSF,recombinant
R12598 T16752 T16753 arg1Of BMDM,were
R12599 T16752 T16754 arg1Of BMDM,of
R12600 T16753 T16758 arg1Of were,as
R12601 T16754 T16753 arg2Of of,were
R12602 T16755 T16756 arg1Of ≥95,%
R12603 T16757 T16754 arg2Of purity,of
R12604 T16757 T16755 arg1Of purity,≥95
R12605 T16759 T16758 arg2Of measured,as
R12606 T16762 T16759 arg1Of cytometry,measured
R12607 T16762 T16760 arg2Of cytometry,by
R12608 T16762 T16761 arg1Of cytometry,flow
R12609 T16762 T16763 arg1Of cytometry,using
R12610 T16764 T16765 arg1Of F4/80,and
R12611 T16766 T16765 arg2Of CD11b,and
R12612 T16768 T16763 arg2Of antibodies,using
R12613 T16768 T16764 arg1Of antibodies,F4/80
R12614 T16768 T16766 arg1Of antibodies,CD11b
R12615 T16768 T16767 arg1Of antibodies,specific
R12616 T16771 T16769 arg2Of isolation,For
R12617 T16771 T16770 arg1Of isolation,the
R12618 T16771 T16772 arg1Of isolation,of
R12619 T16774 T16772 arg2Of macrophages,of
R12620 T16774 T16773 arg1Of macrophages,alveolar
R12621 T16777 T16776 arg1Of trachea,the
R12622 T16777 T16778 arg1Of trachea,was
R12623 T16777 T16779 arg2Of trachea,canulated
R12624 T16779 T16778 arg2Of canulated,was
R12625 T16779 T16780 arg1Of canulated,and
R12626 T16780 T16769 arg1Of and,For
R12627 T16780 T16775 arg1Of and,","
R12628 T16782 T16781 arg1Of lung,the
R12629 T16782 T16783 arg1Of lung,was
R12630 T16782 T16784 arg2Of lung,flushed
R12631 T16784 T16780 arg2Of flushed,and
R12632 T16784 T16783 arg2Of flushed,was
R12633 T16784 T16786 arg1Of flushed,times
R12634 T16786 T16785 arg1Of times,4
R12635 T16786 T16787 arg1Of times,with
R12636 T16786 T16789 arg1Of times,containing
R12637 T16788 T16787 arg2Of HBSS,with
R12638 T16790 T16791 arg1Of 1,mM
R12639 T16792 T16789 arg2Of EDTA,containing
R12640 T16792 T16790 arg1Of EDTA,1
R12641 T16794 T16793 arg1Of macrophages,Alveolar
R12642 T16794 T16795 arg1Of macrophages,were
R12643 T16794 T16796 arg2Of macrophages,cultured
R12644 T16796 T16795 arg2Of cultured,were
R12645 T16796 T16797 arg1Of cultured,in
R12646 T16798 T16797 arg2Of RPMI,in
R12647 T16798 T16799 arg1Of RPMI,1640
R12648 T16798 T16800 arg1Of RPMI,(
R12649 T16798 T16803 arg2Of RPMI,supplemented
R12650 T16801 T16800 arg2Of Gibco,(
R12651 T16802 T16800 arg3Of ),(
R12652 T16803 T16804 arg1Of supplemented,with
R12653 T16805 T16806 arg1Of 1,%
R12654 T16807 T16805 arg1Of FCS,1
R12655 T16807 T16808 arg1Of FCS,","
R12656 T16808 T16812 arg1Of ",",","
R12657 T16809 T16810 arg1Of 2,mM
R12658 T16811 T16808 arg2Of L-glutamine,","
R12659 T16811 T16809 arg1Of L-glutamine,2
R12660 T16812 T16817 arg1Of ",",and
R12661 T16813 T16814 arg1Of 0.4,mM
R12662 T16816 T16812 arg2Of pyruvate,","
R12663 T16816 T16813 arg1Of pyruvate,0.4
R12664 T16816 T16815 arg1Of pyruvate,sodium
R12665 T16817 T16804 arg2Of and,with
R12666 T16818 T16817 arg2Of antibiotics,and
R12948 T17178 T17177 arg1Of blotting,Western
R12949 T17181 T17179 arg2Of lysates,For
R12950 T17181 T17180 arg1Of lysates,total
R12951 T17183 T17184 arg1Of cells,were
R12952 T17183 T17185 arg2Of cells,lysed
R12953 T17185 T17179 arg1Of lysed,For
R12954 T17185 T17182 arg1Of lysed,","
R12955 T17185 T17184 arg2Of lysed,were
R12956 T17185 T17186 arg1Of lysed,at
R12957 T17185 T17188 arg1Of lysed,for
R12958 T17187 T17186 arg2Of 4°C,at
R12959 T17190 T17188 arg2Of min,for
R12960 T17190 T17189 arg1Of min,15
R12961 T17190 T17191 arg1Of min,in
R12962 T17190 T17194 arg1Of min,(
R12963 T17190 T17217 arg2Of min,supplemented
R12964 T17193 T17191 arg2Of buffer,in
R12965 T17193 T17192 arg1Of buffer,lysis
R12966 T17197 T17195 arg1Of NaCl,200
R12967 T17197 T17196 arg1Of NaCl,mM
R12968 T17197 T17198 arg1Of NaCl,","
R12969 T17198 T17202 arg1Of ",",","
R12970 T17199 T17200 arg1Of 1,%
R12971 T17201 T17198 arg2Of NP-40,","
R12972 T17201 T17199 arg1Of NP-40,1
R12973 T17202 T17208 arg1Of ",",","
R12974 T17203 T17204 arg1Of 10,mM
R12975 T17206 T17202 arg2Of pH,","
R12976 T17206 T17203 arg1Of pH,10
R12977 T17206 T17205 arg1Of pH,Tris-HCl
R12978 T17206 T17207 arg1Of pH,7.5
R12979 T17208 T17212 arg1Of ",",","
R12980 T17209 T17210 arg1Of 5,mM
R12981 T17211 T17208 arg2Of EDTA,","
R12982 T17211 T17209 arg1Of EDTA,5
R12983 T17212 T17194 arg2Of ",",(
R12984 T17213 T17214 arg1Of 2,mM
R12985 T17215 T17212 arg2Of DTT,","
R12986 T17215 T17213 arg1Of DTT,2
R12987 T17216 T17194 arg3Of ),(
R12988 T17217 T17218 arg1Of supplemented,with
R12989 T17219 T17220 arg1Of protease,and
R12990 T17221 T17220 arg2Of phosphatase,and
R12991 T17222 T17218 arg2Of inhibitors,with
R12992 T17222 T17219 arg1Of inhibitors,protease
R12993 T17222 T17221 arg1Of inhibitors,phosphatase
R12994 T17223 T17224 arg1Of Nuclear,and
R12995 T17225 T17224 arg2Of cytoplasmic,and
R12996 T17226 T17223 arg1Of lysates,Nuclear
R12997 T17226 T17225 arg1Of lysates,cytoplasmic
R12998 T17226 T17227 arg1Of lysates,were
R12999 T17226 T17228 arg2Of lysates,prepared
R13000 T17228 T17227 arg2Of prepared,were
R13001 T17228 T17229 arg1Of prepared,by
R13002 T17228 T17273 arg1Of prepared,","
R13003 T17230 T17229 arg2Of resuspending,by
R13004 T17230 T17232 arg1Of resuspending,in
R13005 T17230 T17267 arg1Of resuspending,for
R13006 T17231 T17230 arg2Of cells,resuspending
R13007 T17233 T17232 arg2Of B1,in
R13008 T17233 T17234 arg1Of B1,(
R13009 T17237 T17235 arg1Of Hepes,10
R13010 T17237 T17236 arg1Of Hepes,mM
R13011 T17238 T17239 arg1Of pH,7.5
R13012 T17238 T17240 arg1Of pH,","
R13013 T17240 T17244 arg1Of ",",","
R13014 T17241 T17242 arg1Of 10,mM
R13015 T17243 T17240 arg2Of KCl,","
R13016 T17243 T17241 arg1Of KCl,10
R13017 T17244 T17248 arg1Of ",",","
R13018 T17245 T17246 arg1Of 1,mM
R13019 T17247 T17244 arg2Of MgCl2,","
R13020 T17247 T17245 arg1Of MgCl2,1
R13021 T17248 T17237 arg1Of ",",Hepes
R13022 T17248 T17252 arg1Of ",",","
R13023 T17249 T17250 arg1Of 5,%
R13024 T17251 T17248 arg2Of glycerol,","
R13025 T17251 T17249 arg1Of glycerol,5
R13026 T17252 T17256 arg1Of ",",and
R13027 T17253 T17254 arg1Of 0.5,mM
R13028 T17255 T17252 arg2Of EDTA,","
R13029 T17255 T17253 arg1Of EDTA,0.5
R13030 T17256 T17234 arg2Of and,(
R13031 T17256 T17260 arg2Of and,supplemented
R13032 T17257 T17258 arg1Of 0.1,mM
R13033 T17259 T17256 arg2Of EGTA,and
R13034 T17259 T17257 arg1Of EGTA,0.1
R13035 T17260 T17261 arg1Of supplemented,with
R13036 T17262 T17263 arg1Of protease,and
R13037 T17264 T17263 arg2Of phosphatase,and
R13038 T17265 T17261 arg2Of inhibitors,with
R13039 T17265 T17262 arg1Of inhibitors,protease
R13040 T17265 T17264 arg1Of inhibitors,phosphatase
R13041 T17266 T17234 arg3Of ),(
R13042 T17269 T17267 arg2Of min,for
R13043 T17269 T17268 arg1Of min,15
R13044 T17269 T17270 arg1Of min,at
R13045 T17272 T17270 arg2Of Next,at
R13046 T17272 T17271 arg1Of Next,4°C.
R13047 T17275 T17274 arg1Of detergent,NP-40
R13048 T17275 T17276 arg1Of detergent,was
R13049 T17275 T17277 arg2Of detergent,added
R13050 T17277 T17276 arg2Of added,was
R13051 T17277 T17278 arg1Of added,to
R13052 T17277 T17285 arg1Of added,and
R13053 T17281 T17278 arg2Of concentration,to
R13054 T17281 T17279 arg1Of concentration,a
R13055 T17281 T17280 arg1Of concentration,final
R13056 T17281 T17282 arg1Of concentration,of
R13057 T17284 T17282 arg2Of %,of
R13058 T17284 T17283 arg1Of %,0.65
R13059 T17285 T17273 arg2Of and,","
R13060 T17286 T17287 arg1Of cells,were
R13061 T17286 T17288 arg2Of cells,centrifuged
R13062 T17288 T17285 arg2Of centrifuged,and
R13063 T17288 T17287 arg2Of centrifuged,were
R13064 T17288 T17289 arg1Of centrifuged,at
R13065 T17288 T17292 arg1Of centrifuged,for
R13066 T17291 T17289 arg2Of g,at
R13067 T17291 T17290 arg1Of g,500
R13068 T17294 T17292 arg2Of min,for
R13069 T17294 T17293 arg1Of min,5
R13070 T17297 T17295 arg1Of fraction,The
R13071 T17297 T17296 arg1Of fraction,nuclear
R13072 T17297 T17298 arg1Of fraction,containing
R13073 T17297 T17300 arg1Of fraction,was
R13074 T17297 T17301 arg2Of fraction,lyzed
R13075 T17299 T17298 arg2Of pellet,containing
R13076 T17301 T17300 arg2Of lyzed,was
R13077 T17301 T17302 arg1Of lyzed,in
R13078 T17301 T17304 arg1Of lyzed,(
R13079 T17301 T17345 arg1Of lyzed,for
R13080 T17303 T17302 arg2Of B2,in
R13081 T17307 T17305 arg1Of Hepes,20
R13082 T17307 T17306 arg1Of Hepes,mM
R13083 T17309 T17310 arg1Of 7.5,","
R13084 T17310 T17308 arg1Of ",",pH
R13085 T17312 T17310 arg2Of %,","
R13086 T17312 T17311 arg1Of %,1
R13087 T17313 T17309 arg1Of NP-40,7.5
R13088 T17313 T17312 arg1Of NP-40,%
R13089 T17313 T17314 arg1Of NP-40,","
R13090 T17314 T17318 arg1Of ",",","
R13091 T17315 T17316 arg1Of 400,mM
R13092 T17317 T17314 arg2Of NaCl,","
R13093 T17317 T17315 arg1Of NaCl,400
R13094 T17318 T17307 arg1Of ",",Hepes
R13095 T17318 T17322 arg1Of ",",","
R13096 T17319 T17320 arg1Of 10,mM
R13097 T17321 T17318 arg2Of KCl,","
R13098 T17321 T17319 arg1Of KCl,10
R13099 T17322 T17326 arg1Of ",",","
R13100 T17323 T17324 arg1Of 1,mM
R13101 T17325 T17322 arg2Of MgCl2,","
R13102 T17325 T17323 arg1Of MgCl2,1
R13103 T17326 T17330 arg1Of ",",","
R13104 T17327 T17328 arg1Of 20,%
R13105 T17329 T17326 arg2Of glycerol,","
R13106 T17329 T17327 arg1Of glycerol,20
R13107 T17330 T17334 arg1Of ",",and
R13108 T17331 T17332 arg1Of 0.5,mM
R13109 T17333 T17330 arg2Of EDTA,","
R13110 T17333 T17331 arg1Of EDTA,0.5
R13111 T17334 T17304 arg2Of and,(
R13112 T17334 T17338 arg2Of and,supplemented
R13113 T17335 T17336 arg1Of 0.1,mM
R13114 T17337 T17334 arg2Of EGTA,and
R13115 T17337 T17335 arg1Of EGTA,0.1
R13116 T17338 T17339 arg1Of supplemented,with
R13117 T17340 T17341 arg1Of protease,and
R13118 T17342 T17341 arg2Of phosphatase,and
R13119 T17343 T17339 arg2Of inhibitors,with
R13120 T17343 T17340 arg1Of inhibitors,protease
R13121 T17343 T17342 arg1Of inhibitors,phosphatase
R13122 T17344 T17304 arg3Of ),(
R13123 T17347 T17345 arg2Of min,for
R13124 T17347 T17346 arg1Of min,15
R13125 T17347 T17348 arg1Of min,at
R13126 T17349 T17348 arg2Of 4°C.,at
R13127 T17351 T17350 arg1Of lysates,The
R13128 T17351 T17352 arg1Of lysates,were
R13129 T17351 T17354 arg2Of lysates,separated
R13130 T17351 T17358 arg2Of lysates,analyzed
R13131 T17354 T17357 arg1Of separated,and
R13132 T17356 T17354 arg1Of SDS-PAGE,separated
R13133 T17356 T17355 arg2Of SDS-PAGE,by
R13134 T17357 T17300 modOf and,was
R13135 T17357 T17352 arg2Of and,were
R13136 T17357 T17353 arg1Of and,subsequently
R13137 T17358 T17357 arg2Of analyzed,and
R13138 T17361 T17362 arg1Of blotting,and
R13139 T17363 T17362 arg2Of ECL,and
R13140 T17364 T17358 arg1Of detection,analyzed
R13141 T17364 T17359 arg2Of detection,by
R13142 T17364 T17360 arg1Of detection,western
R13143 T17364 T17361 arg1Of detection,blotting
R13144 T17364 T17363 arg1Of detection,ECL
R13145 T17364 T17365 arg1Of detection,(
R13146 T17369 T17365 arg2Of Sciences,(
R13147 T17369 T17366 arg1Of Sciences,Perkin
R13148 T17369 T17367 arg1Of Sciences,Elmer
R13149 T17369 T17368 arg1Of Sciences,Life
R13150 T17370 T17365 arg3Of ),(
R13151 T17371 T17372 arg1Of Immunoblots,were
R13152 T17371 T17373 arg2Of Immunoblots,revealed
R13153 T17373 T17372 arg2Of revealed,were
R13154 T17373 T17374 arg1Of revealed,with
R13155 T17375 T17376 arg1Of anti-A20,","
R13156 T17376 T17378 arg1Of ",",","
R13157 T17377 T17376 arg2Of anti-IκBα,","
R13158 T17378 T17381 arg1Of ",",and
R13159 T17379 T17378 arg2Of anti-p65,","
R13160 T17381 T17380 arg1Of and,","
R13161 T17382 T17381 arg2Of anti-histon,and
R13162 T17383 T17375 arg1Of H1,anti-A20
R13163 T17383 T17377 arg1Of H1,anti-IκBα
R13164 T17383 T17379 arg1Of H1,anti-p65
R13165 T17383 T17382 arg1Of H1,anti-histon
R13166 T17383 T17384 arg1Of H1,(
R13167 T17383 T17388 arg1Of H1,","
R13168 T17386 T17384 arg2Of Cruz,(
R13169 T17386 T17385 arg1Of Cruz,Santa
R13170 T17387 T17384 arg3Of ),(
R13171 T17388 T17393 arg1Of ",",","
R13172 T17389 T17388 arg2Of anti-IRF3,","
R13173 T17389 T17390 arg1Of anti-IRF3,(
R13174 T17391 T17390 arg2Of Invitrogen,(
R13175 T17392 T17390 arg3Of ),(
R13176 T17393 T17374 arg2Of ",",with
R13177 T17394 T17395 arg1Of anti-phospho-IRF3,and
R13178 T17396 T17395 arg2Of anti-phospho-IκBα,and
R13179 T17399 T17394 arg1Of Signaling,anti-phospho-IRF3
R13180 T17399 T17396 arg1Of Signaling,anti-phospho-IκBα
R13181 T17399 T17397 arg2Of Signaling,(
R13182 T17399 T17398 arg1Of Signaling,Cell
R13183 T17399 T17401 arg1Of Signaling,and
R13184 T17400 T17397 arg3Of ),(
R13185 T17401 T17393 arg2Of and,","
R13186 T17405 T17401 arg2Of Biomedicals,and
R13187 T17405 T17402 arg1Of Biomedicals,anti-actin
R13188 T17405 T17403 arg2Of Biomedicals,(
R13189 T17405 T17404 arg1Of Biomedicals,MP
R13190 T17406 T17403 arg3Of ),(
R13191 T17408 T17407 arg1Of density,The
R13192 T17408 T17409 arg1Of density,of
R13193 T17408 T17412 arg1Of density,was
R13194 T17408 T17413 arg2Of density,quantified
R13195 T17411 T17409 arg2Of bands,of
R13196 T17411 T17410 arg1Of bands,the
R13197 T17413 T17412 arg2Of quantified,was
R13198 T17413 T17414 arg1Of quantified,(
R13199 T17413 T17418 arg1Of quantified,with
R13200 T17416 T17414 arg2Of induction,(
R13201 T17416 T17415 arg1Of induction,fold
R13202 T17417 T17414 arg3Of ),(
R13203 T17420 T17421 arg1Of ImageJ,(
R13204 T17422 T17421 arg2Of http,(
R13205 T17423 T17421 arg3Of :,(
R13206 T17424 T17420 arg1Of //rsbweb.nih.gov/ij,ImageJ
R13207 T17424 T17425 arg1Of //rsbweb.nih.gov/ij,)
R13208 T17428 T17418 arg2Of tool,with
R13209 T17428 T17419 arg1Of tool,the
R13210 T17428 T17424 arg1Of tool,//rsbweb.nih.gov/ij
R13211 T17428 T17426 arg1Of tool,Gel
R13212 T17428 T17427 arg1Of tool,analyzer
R13213 T17430 T17429 arg1Of intensities,All
R13214 T17430 T17431 arg1Of intensities,were
R13215 T17430 T17432 arg2Of intensities,calculated
R13216 T17432 T17431 arg2Of calculated,were
R13217 T17432 T17434 arg1Of calculated,to
R13218 T17434 T17433 arg1Of to,relative
R13219 T17437 T17434 arg2Of lane,to
R13220 T17437 T17435 arg1Of lane,the
R13221 T17437 T17436 arg1Of lane,first
R13222 T17437 T17438 arg1Of lane,(
R13223 T17440 T17438 arg2Of 0,(
R13224 T17440 T17439 arg1Of 0, = time
R13225 T17441 T17438 arg3Of ),(
R13508 T17871 T17870 arg1Of cytometry,Flow
R13509 T17872 T17873 arg1Of Lungs,were
R13510 T17872 T17874 arg2Of Lungs,dissected
R13511 T17872 T17876 arg2Of Lungs,incubated
R13512 T17874 T17875 arg1Of dissected,and
R13513 T17875 T17873 arg2Of and,were
R13514 T17876 T17875 arg2Of incubated,and
R13515 T17876 T17877 arg1Of incubated,with
R13516 T17876 T17897 arg1Of incubated,for
R13517 T17879 T17878 arg1Of type,collagenase
R13518 T17879 T17880 arg1Of type,IV
R13519 T17879 T17881 arg1Of type,(
R13520 T17879 T17887 arg1Of type,and
R13521 T17883 T17881 arg2Of mg/ml,(
R13522 T17883 T17882 arg1Of mg/ml,1
R13523 T17883 T17884 arg1Of mg/ml,;
R13524 T17885 T17884 arg2Of Sigma,;
R13525 T17886 T17881 arg3Of ),(
R13526 T17887 T17877 arg2Of and,with
R13527 T17888 T17887 arg2Of DNAse,and
R13528 T17888 T17889 arg1Of DNAse,(
R13529 T17888 T17895 arg1Of DNAse,at
R13530 T17891 T17889 arg2Of U/ml,(
R13531 T17891 T17890 arg1Of U/ml,100
R13532 T17891 T17892 arg1Of U/ml,;
R13533 T17893 T17892 arg2Of Roche,;
R13534 T17894 T17889 arg3Of ),(
R13535 T17896 T17895 arg2Of 37°C,at
R13536 T17899 T17897 arg2Of min,for
R13537 T17899 T17898 arg1Of min,30
R13538 T17902 T17903 arg1Of samples,were
R13539 T17902 T17904 arg2Of samples,filtered
R13540 T17904 T17900 arg1Of filtered,Subsequently
R13541 T17904 T17901 arg1Of filtered,","
R13542 T17904 T17903 arg2Of filtered,were
R13543 T17904 T17905 arg1Of filtered,through
R13544 T17908 T17909 arg1Of µm,and
R13545 T17909 T17907 arg1Of and,70
R13546 T17910 T17909 arg2Of 40,and
R13547 T17913 T17905 arg2Of mesh,through
R13548 T17913 T17906 arg1Of mesh,a
R13549 T17913 T17908 arg1Of mesh,µm
R13550 T17913 T17910 arg1Of mesh,40
R13551 T17913 T17911 arg1Of mesh,µm
R13552 T17913 T17912 arg1Of mesh,nylon
R13553 T17916 T17914 arg2Of preparation,For
R13554 T17916 T17915 arg1Of preparation,the
R13555 T17916 T17917 arg1Of preparation,of
R13556 T17918 T17917 arg2Of BAL,of
R13557 T17920 T17921 arg1Of trachea,were
R13558 T17920 T17922 arg2Of trachea,canulated
R13559 T17922 T17921 arg2Of canulated,were
R13560 T17922 T17923 arg1Of canulated,and
R13561 T17923 T17914 arg1Of and,For
R13562 T17923 T17919 arg1Of and,","
R13563 T17925 T17924 arg1Of lumen,airway
R13564 T17925 T17926 arg1Of lumen,was
R13565 T17925 T17927 arg2Of lumen,flushed
R13566 T17927 T17923 arg2Of flushed,and
R13567 T17927 T17926 arg2Of flushed,was
R13568 T17927 T17929 arg1Of flushed,times
R13569 T17927 T17930 arg1Of flushed,with
R13570 T17929 T17928 arg1Of times,4
R13571 T17931 T17930 arg2Of HBSS,with
R13572 T17931 T17932 arg1Of HBSS,with
R13573 T17933 T17934 arg1Of 1,mM
R13574 T17935 T17932 arg2Of EDTA,with
R13575 T17935 T17933 arg1Of EDTA,1
R13576 T17937 T17936 arg1Of iodide,Propidium
R13577 T17937 T17938 arg1Of iodide,was
R13578 T17937 T17939 arg2Of iodide,used
R13579 T17939 T17938 arg2Of used,was
R13580 T17941 T17939 arg3Of discriminate,used
R13581 T17941 T17940 arg1Of discriminate,to
R13582 T17941 T17942 arg1Of discriminate,between
R13583 T17943 T17944 arg1Of live,and
R13584 T17945 T17944 arg2Of dead,and
R13585 T17946 T17942 arg2Of cells,between
R13586 T17946 T17943 arg1Of cells,live
R13587 T17946 T17945 arg1Of cells,dead
R13786 T18306 T18305 arg1Of quantification,Cytokine
R13787 T18309 T18307 arg2Of ELISA,For
R13788 T18309 T18308 arg1Of ELISA,TNF
R13789 T18312 T18311 arg1Of plates,96-well
R13790 T18312 T18313 arg1Of plates,were
R13791 T18312 T18314 arg2Of plates,coated
R13792 T18314 T18307 arg1Of coated,For
R13793 T18314 T18310 arg1Of coated,","
R13794 T18314 T18313 arg2Of coated,were
R13795 T18314 T18315 arg1Of coated,with
R13796 T18317 T18316 arg1Of coating,TNF
R13797 T18317 T18318 arg1Of coating,(
R13798 T18317 T18323 arg1Of coating,and
R13799 T18319 T18318 arg2Of TN3-19,(
R13800 T18319 T18320 arg1Of TN3-19,","
R13801 T18321 T18320 arg2Of eBioscience,","
R13802 T18322 T18318 arg3Of ),(
R13803 T18323 T18315 arg2Of and,with
R13804 T18324 T18325 arg1Of detection,(
R13805 T18326 T18325 arg2Of R4-6A2,(
R13806 T18326 T18327 arg1Of R4-6A2,","
R13807 T18328 T18327 arg2Of eBioscience,","
R13808 T18329 T18325 arg3Of ),(
R13809 T18330 T18323 arg2Of antibodies,and
R13810 T18330 T18324 arg1Of antibodies,detection
R13811 T18331 T18332 arg1Of IFNα,and
R13812 T18333 T18332 arg2Of IFNβ,and
R13813 T18335 T18331 arg1Of levels,IFNα
R13814 T18335 T18333 arg1Of levels,IFNβ
R13815 T18335 T18334 arg1Of levels,protein
R13816 T18335 T18336 arg1Of levels,were
R13817 T18335 T18337 arg2Of levels,determined
R13818 T18337 T18336 arg2Of determined,were
R13819 T18337 T18338 arg1Of determined,with
R13820 T18341 T18338 arg2Of kit,with
R13821 T18341 T18339 arg1Of kit,an
R13822 T18341 T18340 arg1Of kit,ELISA
R13823 T18341 T18342 arg1Of kit,(
R13824 T18345 T18342 arg2Of Laboratories,(
R13825 T18345 T18343 arg1Of Laboratories,PBL
R13826 T18345 T18344 arg1Of Laboratories,Biomedical
R13827 T18346 T18342 arg3Of ),(
R13828 T18349 T18347 arg2Of ELISA,For
R13829 T18349 T18348 arg1Of ELISA,IFNγ
R13830 T18352 T18351 arg1Of plates,96-well
R13831 T18352 T18353 arg1Of plates,were
R13832 T18352 T18354 arg2Of plates,coated
R13833 T18354 T18347 arg1Of coated,For
R13834 T18354 T18350 arg1Of coated,","
R13835 T18354 T18353 arg2Of coated,were
R13836 T18354 T18355 arg1Of coated,with
R13837 T18357 T18356 arg1Of coating,IFNγ
R13838 T18357 T18358 arg1Of coating,(
R13839 T18357 T18361 arg1Of coating,and
R13840 T18359 T18358 arg2Of XMG1.2,(
R13841 T18360 T18358 arg3Of ),(
R13842 T18361 T18355 arg2Of and,with
R13843 T18364 T18363 arg2Of R4-6A2,(
R13844 T18365 T18363 arg3Of ),(
R13845 T18366 T18361 arg2Of antibodies,and
R13846 T18366 T18362 arg1Of antibodies,detection
R13847 T18366 T18363 arg1Of antibodies,(
R13848 T18366 T18367 arg1Of antibodies,(
R13849 T18368 T18367 arg2Of eBiosciences,(
R13850 T18369 T18367 arg3Of ),(
R13851 T18370 T18371 arg1Of Detection,of
R13852 T18370 T18384 arg1Of Detection,was
R13853 T18370 T18385 arg2Of Detection,performed
R13854 T18372 T18373 arg1Of MCP-1,","
R13855 T18373 T18375 arg1Of ",",","
R13856 T18374 T18373 arg2Of KC,","
R13857 T18375 T18377 arg1Of ",",","
R13858 T18376 T18375 arg2Of TNF,","
R13859 T18377 T18379 arg1Of ",",and
R13860 T18378 T18377 arg2Of IL-1β,","
R13861 T18379 T18371 arg2Of and,of
R13862 T18379 T18381 arg1Of and,in
R13863 T18380 T18379 arg2Of IL-6,and
R13864 T18383 T18381 arg2Of fluid,in
R13865 T18383 T18382 arg1Of fluid,BAL
R13866 T18385 T18384 arg2Of performed,was
R13867 T18386 T18385 arg3Of using,performed
R13868 T18386 T18392 arg1Of using,according
R13869 T18389 T18388 arg2Of BioRad,(
R13870 T18390 T18388 arg3Of ),(
R13871 T18391 T18386 arg2Of technology,using
R13872 T18391 T18387 arg1Of technology,Bioplex
R13873 T18391 T18388 arg1Of technology,(
R13874 T18393 T18392 arg2Of to,according
R13875 T18395 T18394 arg1Of manufacturer,the
R13876 T18395 T18396 arg2Of manufacturer,'s
R13877 T18397 T18393 arg2Of instructions,to
R13878 T18397 T18396 arg1Of instructions,'s
R13879 T18399 T18398 arg1Of technology,Milliplex
R13880 T18399 T18400 arg1Of technology,(
R13881 T18399 T18403 arg1Of technology,was
R13882 T18399 T18404 arg2Of technology,used
R13883 T18401 T18400 arg2Of Millipore,(
R13884 T18402 T18400 arg3Of ),(
R13885 T18404 T18403 arg2Of used,was
R13886 T18404 T18405 arg1Of used,for
R13887 T18407 T18405 arg2Of detection,for
R13888 T18407 T18406 arg1Of detection,the
R13889 T18407 T18408 arg1Of detection,of
R13890 T18407 T18410 arg1Of detection,in
R13891 T18409 T18408 arg2Of MIP-2,of
R13892 T18412 T18410 arg2Of fluid,in
R13893 T18412 T18411 arg1Of fluid,BAL
R14018 T18696 T18695 arg1Of isolation,RNA
R14019 T18696 T18697 arg1Of isolation,","
R14020 T18697 T18700 arg1Of ",",and
R14021 T18699 T18697 arg2Of synthesis,","
R14022 T18699 T18698 arg1Of synthesis,cDNA
R14023 T18701 T18700 arg2Of qPCR,and
R14024 T18703 T18702 arg1Of RNA,Total
R14025 T18703 T18704 arg1Of RNA,was
R14026 T18703 T18705 arg2Of RNA,extracted
R14027 T18705 T18704 arg2Of extracted,was
R14028 T18705 T18706 modOf extracted,using
R14029 T18705 T18715 arg1Of extracted,and
R14030 T18708 T18707 arg1Of Total,Aurum
R14031 T18711 T18706 arg2Of kit,using
R14032 T18711 T18708 arg1Of kit,Total
R14033 T18711 T18709 arg1Of kit,RNA
R14034 T18711 T18710 arg1Of kit,mini
R14035 T18711 T18712 arg1Of kit,(
R14036 T18713 T18712 arg2Of BioRad,(
R14037 T18714 T18712 arg3Of ),(
R14038 T18716 T18717 arg2Of reverse,transcribed
R14039 T18716 T18735 arg1Of reverse,was
R14040 T18716 T18736 arg2Of reverse,performed
R14041 T18717 T18718 arg1Of transcribed,into
R14042 T18717 T18720 arg1Of transcribed,with
R14043 T18717 T18728 arg1Of transcribed,according
R14044 T18719 T18718 arg2Of cDNA,into
R14045 T18724 T18720 arg2Of kit,with
R14046 T18724 T18721 arg1Of kit,iScript
R14047 T18724 T18722 arg1Of kit,cDNA
R14048 T18724 T18723 arg1Of kit,synthesis
R14049 T18724 T18725 arg1Of kit,(
R14050 T18726 T18725 arg2Of BioRad,(
R14051 T18727 T18725 arg3Of ),(
R14052 T18729 T18728 arg2Of to,according
R14053 T18731 T18730 arg1Of manufacturer,the
R14054 T18731 T18732 arg2Of manufacturer,'s
R14055 T18734 T18729 arg2Of qPCR,to
R14056 T18734 T18732 arg1Of qPCR,'s
R14057 T18734 T18733 arg1Of qPCR,instructions.
R14058 T18736 T18715 arg2Of performed,and
R14059 T18736 T18735 arg2Of performed,was
R14060 T18736 T18737 arg1Of performed,by
R14061 T18736 T18763 arg1Of performed,:
R14062 T18738 T18737 arg2Of using,by
R14063 T18741 T18739 arg1Of I,SYBR
R14064 T18741 T18740 arg1Of I,Green
R14065 T18743 T18738 arg2Of mix,using
R14066 T18743 T18741 arg1Of mix,I
R14067 T18743 T18742 arg1Of mix,master
R14068 T18743 T18744 arg1Of mix,I
R14069 T18743 T18745 arg1Of mix,(
R14070 T18743 T18748 arg1Of mix,in
R14071 T18743 T18761 arg1Of mix,:
R14072 T18746 T18745 arg2Of Roche,(
R14073 T18747 T18745 arg3Of ),(
R14074 T18750 T18751 arg1Of Lightcycler,480
R14075 T18753 T18748 arg2Of system,in
R14076 T18753 T18749 arg1Of system,the
R14077 T18753 T18750 arg1Of system,Lightcycler
R14078 T18753 T18752 arg1Of system,detection
R14079 T18753 T18754 arg1Of system,(
R14080 T18753 T18757 arg1Of system,with
R14081 T18755 T18754 arg2Of Roche,(
R14082 T18756 T18754 arg3Of ),(
R14083 T18760 T18757 arg2Of primers,with
R14084 T18760 T18758 arg1Of primers,the
R14085 T18760 T18759 arg1Of primers,following
R14086 T18762 T18761 arg2Of HPRT,:
R14087 T18764 T18765 arg1Of 5′-AGTGTTGGATACAGGCCAGAC-3′,and
R14088 T18765 T18767 arg1Of and,;
R14089 T18766 T18765 arg2Of 5′CGTGATTCAAATCCCTGAAGT-3′,and
R14090 T18768 T18767 arg2Of IL-6,;
R14091 T18768 T18769 arg1Of IL-6,:
R14092 T18770 T18771 arg1Of 5′-GAGGATACCACTCCCAACAGACC-3′,and
R14093 T18771 T18773 arg1Of and,;
R14094 T18772 T18771 arg2Of 5′-AAGTGCATCATCGTTGTTCATACA-3′,and
R14095 T18774 T18773 arg2Of IFNβ,;
R14096 T18774 T18775 arg1Of IFNβ,:
R14097 T18776 T18777 arg1Of 5′-TCAGAATGAGTGGTGGTTGC-3′,and
R14098 T18777 T18779 arg1Of and,;
R14099 T18778 T18777 arg2Of 5′-GACCTTTCAAATGCAGTAGATTCA-3′,and
R14100 T18780 T18779 arg2Of A20,;
R14101 T18780 T18781 arg1Of A20,:
R14102 T18782 T18783 arg1Of 5′-AAACCAATGGTGATGGAAACTG-3′,and
R14103 T18783 T18785 arg1Of and,;
R14104 T18784 T18783 arg2Of 5′-GTTGTCCCATTCGTCATTCC-3′,and
R14105 T18786 T18785 arg2Of CCL2,;
R14106 T18786 T18787 arg1Of CCL2,:
R14107 T18788 T18789 arg1Of 5′-TTAAAAACCTGGATCGGAACCAA-3′,and
R14108 T18789 T18791 arg1Of and,;
R14109 T18790 T18789 arg2Of 5′-GCATTAGCTTCAGATTTACGGGT-3′,and
R14110 T18792 T18791 arg2Of CXCL1,;
R14111 T18792 T18793 arg1Of CXCL1,:
R14112 T18794 T18795 arg1Of 5′-GAGCCTCTAACCAGTTCCAG-3′,and
R14113 T18795 T18799 arg1Of and,:
R14114 T18796 T18797 arg1Of 5′-TGAGTGTGGCTATGACTTCG-3′,and
R14115 T18797 T18795 arg2Of and,and
R14116 T18798 T18797 arg2Of IFNα4,and
R14117 T18800 T18801 arg1Of 5′-TGATGAGCTACTACTGGTCAGC-3′,and
R14118 T18802 T18801 arg2Of 5′-GATCTCTTAGCACAAGGATGGC-3′,and
R14119 T18803 T18804 arg1Of Primers,were
R14120 T18803 T18805 arg2Of Primers,designed
R14121 T18805 T18804 arg2Of designed,were
R14122 T18805 T18806 arg1Of designed,with
R14123 T18807 T18806 arg2Of PerlPrimer,with
R14124 T18807 T18809 arg1Of PerlPrimer,http
R14125 T18807 T18811 arg1Of PerlPrimer,//perlprimer.sourceforge.net
R14126 T18807 T18812 arg1Of PerlPrimer,)
R14127 T18809 T18810 arg1Of http,:
R14128 T18810 T18808 arg1Of :,(
R14129 T18811 T18810 arg2Of //perlprimer.sourceforge.net,:
R14130 T18813 T18814 arg1Of Quantification,was
R14131 T18813 T18815 arg2Of Quantification,performed
R14132 T18815 T18814 arg2Of performed,was
R14133 T18816 T18815 arg3Of using,performed
R14134 T18820 T18816 arg2Of method,using
R14135 T18820 T18817 arg1Of method,the
R14136 T18820 T18818 arg1Of method,comparative
R14137 T18820 T18819 arg1Of method,CT
R14138 T18820 T18821 arg1Of method,(
R14139 T18822 T18821 arg2Of ΔΔCT,(
R14140 T18823 T18821 arg3Of ),(
R14141 T18824 T18825 arg1Of Results,are
R14142 T18824 T18826 arg2Of Results,expressed
R14143 T18826 T18825 arg2Of expressed,are
R14144 T18826 T18828 arg1Of expressed,to
R14145 T18828 T18827 arg1Of to,relative
R14146 T18830 T18828 arg2Of values,to
R14147 T18830 T18829 arg1Of values,HPRT
R14349 T19108 T19109 arg1Of Results,are
R14350 T19108 T19110 arg2Of Results,expressed
R14351 T19110 T19109 arg2Of expressed,are
R14352 T19110 T19111 arg1Of expressed,as
R14353 T19115 T19111 arg2Of SEM,as
R14354 T19115 T19112 arg1Of SEM,the
R14355 T19115 T19113 arg1Of SEM,mean
R14356 T19115 T19114 arg1Of SEM,±
R14357 T19117 T19116 arg1Of significance,Statistical
R14358 T19117 T19118 arg1Of significance,between
R14359 T19117 T19120 arg1Of significance,was
R14360 T19117 T19121 arg2Of significance,assessed
R14361 T19119 T19118 arg2Of groups,between
R14362 T19121 T19120 arg2Of assessed,was
R14363 T19122 T19121 arg3Of using,assessed
R14364 T19124 T19122 arg2Of ANOVA,using
R14365 T19124 T19123 arg1Of ANOVA,two-way
R14366 T19126 T19125 arg1Of differences,The
R14367 T19126 T19127 arg1Of differences,for
R14368 T19126 T19139 arg1Of differences,were
R14369 T19126 T19140 arg2Of differences,calculated
R14370 T19129 T19128 arg1Of vivo,in
R14371 T19130 T19127 arg2Of experiments,for
R14372 T19130 T19129 arg1Of experiments,vivo
R14373 T19130 T19131 arg1Of experiments,(
R14374 T19134 T19132 arg1Of 5,at
R14375 T19134 T19133 arg1Of 5,least
R14376 T19135 T19131 arg2Of mice,(
R14377 T19135 T19134 arg1Of mice,5
R14378 T19135 T19136 arg1Of mice,per
R14379 T19137 T19136 arg2Of group,per
R14380 T19138 T19131 arg3Of ),(
R14381 T19140 T19139 arg2Of calculated,were
R14382 T19140 T19141 modOf calculated,using
R14383 T19141 T19145 arg1Of using,for
R14384 T19144 T19141 arg2Of U-test,using
R14385 T19144 T19142 arg1Of U-test,the
R14386 T19144 T19143 arg1Of U-test,Mann-Whitney
R14387 T19147 T19145 arg2Of data,for
R14388 T19147 T19146 arg1Of data,unpaired
R14389 T19149 T19148 arg1Of significance,Statistical
R14390 T19149 T19150 arg1Of significance,of
R14391 T19149 T19152 arg1Of significance,between
R14392 T19149 T19155 arg1Of significance,was
R14393 T19149 T19156 arg2Of significance,analyzed
R14394 T19151 T19150 arg2Of differences,of
R14395 T19154 T19152 arg2Of rates,between
R14396 T19154 T19153 arg1Of rates,survival
R14397 T19156 T19155 arg2Of analyzed,was
R14398 T19156 T19157 arg1Of analyzed,by
R14399 T19158 T19157 arg2Of comparing,by
R14400 T19160 T19158 arg2Of curves,comparing
R14401 T19160 T19159 arg1Of curves,Kaplan-Meier
R14402 T19160 T19161 arg1Of curves,using
R14403 T19164 T19161 arg2Of test,using
R14404 T19164 T19162 arg1Of test,the
R14405 T19164 T19163 arg1Of test,log-rank
R14406 T19164 T19165 arg1Of test,(
R14407 T19167 T19166 arg1Of Prism,GraphPad
R14408 T19168 T19165 arg2Of version,(
R14409 T19168 T19167 arg1Of version,Prism
R14410 T19168 T19169 arg1Of version,5
R14411 T19168 T19170 arg1Of version,","
R14412 T19171 T19170 arg2Of GraphPad,","
R14413 T19171 T19172 arg1Of GraphPad,","
R14414 T19174 T19172 arg2Of Diego,","
R14415 T19174 T19173 arg1Of Diego,San
R14416 T19174 T19175 arg1Of Diego,","
R14417 T19176 T19175 arg2Of CA,","
R14418 T19177 T19165 arg3Of ),(
R14529 T19463 T19464 arg1Of A20,inhibits
R14530 T19465 T19466 arg1Of NF-κB,and
R14531 T19467 T19466 arg2Of IRF3,and
R14532 T19468 T19464 arg2Of activation,inhibits
R14533 T19468 T19465 arg1Of activation,NF-κB
R14534 T19468 T19467 arg1Of activation,IRF3
R14535 T19468 T19469 arg1Of activation,in
R14536 T19469 T19471 arg1Of in,to
R14537 T19470 T19469 arg2Of response,in
R14538 T19473 T19469 arg3Of stimulation,in
R14539 T19473 T19472 arg1Of stimulation,RIG-I
R14540 T19475 T19474 arg2Of A,(
R14541 T19476 T19474 arg3Of ),(
R14542 T19478 T19474 arg1Of cells,(
R14543 T19478 T19477 arg1Of cells,HEK293T
R14544 T19478 T19479 arg1Of cells,were
R14545 T19478 T19480 arg2Of cells,transfected
R14546 T19480 T19479 arg2Of transfected,were
R14547 T19480 T19481 arg1Of transfected,with
R14548 T19482 T19483 arg1Of NF-κB,(
R14549 T19482 T19486 arg1Of NF-κB,","
R14550 T19484 T19483 arg2Of left,(
R14551 T19485 T19483 arg3Of ),(
R14552 T19486 T19491 arg1Of ",",or
R14553 T19487 T19486 arg2Of IRF3,","
R14554 T19487 T19488 arg1Of IRF3,(
R14555 T19489 T19488 arg2Of middle,(
R14556 T19490 T19488 arg3Of ),(
R14557 T19491 T19509 arg1Of or,","
R14558 T19495 T19492 arg1Of reporter,IRF7
R14559 T19495 T19493 arg1Of reporter,dependent
R14560 T19495 T19494 arg1Of reporter,luciferase
R14561 T19495 T19496 arg1Of reporter,(
R14562 T19497 T19496 arg2Of right,(
R14563 T19498 T19496 arg3Of ),(
R14564 T19499 T19491 arg2Of plasmids,or
R14565 T19499 T19495 arg1Of plasmids,reporter
R14566 T19499 T19500 arg1Of plasmids,","
R14567 T19499 T19502 arg1Of plasmids,with
R14568 T19502 T19501 arg1Of with,together
R14569 T19503 T19502 arg2Of plasmids,with
R14570 T19503 T19504 arg1Of plasmids,expressing
R14571 T19505 T19504 arg2Of RIG-I,expressing
R14572 T19505 T19506 arg1Of RIG-I,(
R14573 T19507 T19506 arg2Of 2CARD,(
R14574 T19508 T19506 arg3Of ),(
R14575 T19509 T19514 arg1Of ",",and
R14576 T19510 T19509 arg2Of IRF7,","
R14577 T19510 T19511 arg1Of IRF7,(
R14578 T19512 T19511 arg2Of right,(
R14579 T19513 T19511 arg3Of ),(
R14580 T19514 T19481 arg2Of and,with
R14581 T19516 T19514 arg2Of amounts,and
R14582 T19516 T19515 arg1Of amounts,increasing
R14583 T19516 T19517 arg1Of amounts,of
R14584 T19518 T19517 arg2Of A20,of
R14585 T19520 T19519 arg1Of activity,Luciferase
R14586 T19520 T19521 arg1Of activity,in
R14587 T19520 T19524 arg1Of activity,was
R14588 T19520 T19525 arg2Of activity,analyzed
R14589 T19523 T19521 arg2Of extracts,in
R14590 T19523 T19522 arg1Of extracts,cell
R14591 T19525 T19524 arg2Of analyzed,was
R14592 T19525 T19526 arg1Of analyzed,in
R14593 T19528 T19526 arg2Of luminometer,in
R14594 T19528 T19527 arg1Of luminometer,a
R14595 T19529 T19530 arg1Of Numbers,are
R14596 T19531 T19532 arg1Of averages,+/−
R14597 T19532 T19530 arg2Of +/−,are
R14598 T19533 T19532 arg2Of SD,+/−
R14599 T19533 T19534 arg1Of SD,of
R14600 T19533 T19550 modOf SD,were
R14601 T19536 T19534 arg2Of samples,of
R14602 T19536 T19535 arg1Of samples,3
R14603 T19536 T19537 arg1Of samples,per
R14604 T19538 T19537 arg2Of set-up.,per
R14605 T19540 T19539 arg2Of B–D,(
R14606 T19541 T19539 arg3Of ),(
R14607 T19542 T19543 arg1Of A20myel-KO,and
R14608 T19544 T19543 arg2Of wild,and
R14609 T19547 T19546 arg2Of A20myel-WT,(
R14610 T19548 T19546 arg3Of ),(
R14611 T19549 T19539 arg1Of BMDM,(
R14612 T19549 T19542 arg1Of BMDM,A20myel-KO
R14613 T19549 T19544 arg1Of BMDM,wild
R14614 T19549 T19545 arg1Of BMDM,type
R14615 T19549 T19546 arg1Of BMDM,(
R14616 T19549 T19550 arg1Of BMDM,were
R14617 T19549 T19551 arg2Of BMDM,transfected
R14618 T19549 T19561 arg2Of BMDM,analyzed
R14619 T19551 T19552 arg1Of transfected,with
R14620 T19551 T19560 arg1Of transfected,and
R14621 T19554 T19552 arg2Of poly,with
R14622 T19554 T19553 arg1Of poly,LMW
R14623 T19554 T19555 arg1Of poly,(
R14624 T19558 T19555 arg2Of C,(
R14625 T19558 T19556 arg1Of C,I
R14626 T19558 T19557 arg1Of C,:
R14627 T19559 T19555 arg3Of ),(
R14628 T19560 T19550 arg2Of and,were
R14629 T19561 T19560 arg2Of analyzed,and
R14630 T19561 T19562 arg1Of analyzed,at
R14631 T19561 T19569 arg1Of analyzed,after
R14632 T19565 T19562 arg2Of points,at
R14633 T19565 T19563 arg1Of points,different
R14634 T19565 T19564 arg1Of points,time
R14635 T19565 T19566 arg1Of points,(
R14636 T19567 T19566 arg2Of minutes,(
R14637 T19568 T19566 arg3Of ),(
R14638 T19571 T19569 arg2Of start,after
R14639 T19571 T19570 arg1Of start,the
R14640 T19571 T19572 arg1Of start,of
R14641 T19573 T19574 arg1Of transfection,for
R14642 T19573 T19580 arg1Of transfection,and
R14643 T19576 T19577 arg1Of phosphorylation,and
R14644 T19577 T19574 arg2Of and,for
R14645 T19577 T19575 arg1Of and,IκBα
R14646 T19578 T19577 arg2Of degradation,and
R14647 T19580 T19572 arg2Of and,of
R14648 T19580 T19579 arg1Of and,","
R14649 T19580 T19583 arg1Of and,by
R14650 T19582 T19580 arg2Of phosphorylation,and
R14651 T19582 T19581 arg1Of phosphorylation,IRF3
R14652 T19584 T19583 arg2Of immunoblotting,by
R14653 T19584 T19585 arg1Of immunoblotting,of
R14654 T19588 T19585 arg2Of extracts,of
R14655 T19588 T19586 arg1Of extracts,total
R14656 T19588 T19587 arg1Of extracts,cell
R14657 T19588 T19589 arg1Of extracts,(
R14658 T19590 T19589 arg2Of B,(
R14659 T19591 T19589 arg3Of ),(
R14660 T19593 T19592 arg1Of band,The
R14661 T19593 T19594 arg1Of band,that
R14662 T19593 T19595 arg1Of band,is
R14663 T19593 T19597 arg2Of band,recognized
R14664 T19593 T19608 arg1Of band,can
R14665 T19593 T19609 arg1Of band,be
R14666 T19593 T19610 arg2Of band,used
R14667 T19597 T19595 arg2Of recognized,is
R14668 T19597 T19596 arg1Of recognized,non-specifically
R14669 T19601 T19597 arg1Of antibody,recognized
R14670 T19601 T19598 arg2Of antibody,by
R14671 T19601 T19599 arg1Of antibody,the
R14672 T19601 T19600 arg1Of antibody,anti-IκBα
R14673 T19601 T19602 arg1Of antibody,(
R14674 T19603 T19602 arg2Of indicated,(
R14675 T19606 T19603 arg1Of asterisk,indicated
R14676 T19606 T19604 arg2Of asterisk,by
R14677 T19606 T19605 arg1Of asterisk,an
R14678 T19607 T19602 arg3Of ),(
R14679 T19610 T19608 arg2Of used,can
R14680 T19610 T19609 arg2Of used,be
R14681 T19610 T19611 arg1Of used,as
R14682 T19614 T19611 arg2Of control,as
R14683 T19614 T19612 arg1Of control,a
R14684 T19614 T19613 arg1Of control,loading
R14685 T19616 T19615 arg1Of translocation,Nuclear
R14686 T19616 T19617 arg1Of translocation,of
R14687 T19616 T19624 arg1Of translocation,was
R14688 T19616 T19625 arg2Of translocation,analyzed
R14689 T19618 T19619 arg1Of NF-κB,(
R14690 T19618 T19622 arg1Of NF-κB,and
R14691 T19620 T19619 arg2Of p65,(
R14692 T19621 T19619 arg3Of ),(
R14693 T19622 T19617 arg2Of and,of
R14694 T19623 T19622 arg2Of IRF3,and
R14695 T19625 T19624 arg2Of analyzed,was
R14696 T19627 T19625 arg1Of immunoblotting,analyzed
R14697 T19627 T19626 arg2Of immunoblotting,by
R14698 T19627 T19628 arg1Of immunoblotting,of
R14699 T19629 T19630 arg1Of cytoplasmic,or
R14700 T19631 T19630 arg2Of nuclear,or
R14701 T19632 T19628 arg2Of fractions,of
R14702 T19632 T19629 arg1Of fractions,cytoplasmic
R14703 T19632 T19631 arg1Of fractions,nuclear
R14704 T19632 T19633 arg1Of fractions,(
R14705 T19634 T19633 arg2Of C,(
R14706 T19635 T19633 arg3Of ),(
R14707 T19636 T19637 arg1Of Quantification,of
R14708 T19636 T19640 arg1Of Quantification,for
R14709 T19636 T19645 arg1Of Quantification,is
R14710 T19636 T19646 arg2Of Quantification,shown
R14711 T19639 T19637 arg2Of density,of
R14712 T19639 T19638 arg1Of density,band
R14713 T19642 T19643 arg1Of p65,and
R14714 T19643 T19640 arg2Of and,for
R14715 T19643 T19641 arg1Of and,nuclear
R14716 T19644 T19643 arg2Of IRF3,and
R14717 T19646 T19645 arg2Of shown,is
R14718 T19646 T19647 arg1Of shown,in
R14719 T19649 T19647 arg2Of graphs,in
R14720 T19649 T19648 arg1Of graphs,bar
R14721 T19649 T19650 arg1Of graphs,(
R14722 T19651 T19650 arg2Of expressed,(
R14723 T19651 T19652 arg1Of expressed,as
R14724 T19651 T19660 arg1Of expressed,;
R14725 T19651 T19662 arg1Of expressed,0
R14726 T19654 T19652 arg2Of density,as
R14727 T19654 T19653 arg1Of density,relative
R14728 T19654 T19655 arg1Of density,compared
R14729 T19656 T19655 arg2Of to,compared
R14730 T19659 T19656 arg2Of lane,to
R14731 T19659 T19657 arg1Of lane,the
R14732 T19659 T19658 arg1Of lane,first
R14733 T19662 T19661 arg1Of 0, = time
R14734 T19663 T19650 arg3Of ),(
R14735 T19664 T19665 arg1Of IL-6,","
R14736 T19665 T19667 arg1Of ",",and
R14737 T19666 T19665 arg2Of TNF,","
R14738 T19668 T19667 arg2Of IFNβ,and
R14739 T19669 T19664 arg1Of levels,IL-6
R14740 T19669 T19666 arg1Of levels,TNF
R14741 T19669 T19668 arg1Of levels,IFNβ
R14742 T19669 T19670 arg1Of levels,in
R14743 T19669 T19680 arg1Of levels,were
R14744 T19669 T19681 arg2Of levels,determined
R14745 T19672 T19670 arg2Of supernatant,in
R14746 T19672 T19671 arg1Of supernatant,the
R14747 T19672 T19673 arg1Of supernatant,of
R14748 T19674 T19673 arg2Of cells,of
R14749 T19674 T19675 arg2Of cells,used
R14750 T19675 T19676 arg1Of used,in
R14751 T19678 T19676 arg2Of B,in
R14752 T19678 T19677 arg2Of B,(
R14753 T19679 T19677 arg3Of ),(
R14754 T19681 T19680 arg2Of determined,were
R14755 T19683 T19684 arg1Of bioassay,(
R14756 T19683 T19687 arg1Of bioassay,and
R14757 T19685 T19684 arg2Of IL-6,(
R14758 T19686 T19684 arg3Of ),(
R14759 T19687 T19694 arg1Of and,as
R14760 T19687 T19699 arg1Of and,and
R14761 T19688 T19687 arg2Of ELISA,and
R14762 T19688 T19689 arg1Of ELISA,(
R14763 T19690 T19691 arg1Of TNF,and
R14764 T19691 T19689 arg2Of and,(
R14765 T19692 T19691 arg2Of IFNβ,and
R14766 T19693 T19689 arg3Of ),(
R14767 T19695 T19694 arg2Of described,as
R14768 T19695 T19696 arg1Of described,in
R14769 T19698 T19696 arg2Of ‘materials,in
R14770 T19698 T19697 arg1Of ‘materials,the
R14771 T19699 T19681 arg1Of and,determined
R14772 T19699 T19682 arg2Of and,by
R14773 T19701 T19699 arg2Of section,and
R14774 T19701 T19700 arg1Of section,methods’
R14775 T19701 T19702 arg1Of section,(
R14776 T19703 T19702 arg2Of D,(
R14777 T19704 T19702 arg3Of ),(
R14778 T19705 T19706 arg1Of Data,are
R14779 T19705 T19707 arg1Of Data,representative
R14780 T19707 T19706 arg2Of representative,are
R14781 T19707 T19708 arg1Of representative,of
R14782 T19711 T19708 arg2Of experiments,of
R14783 T19711 T19709 arg1Of experiments,2
R14784 T19711 T19710 arg1Of experiments,independent
R15147 T20324 T20326 arg1Of A20,regulates
R15148 T20326 T20325 arg1Of regulates,negatively
R15149 T20329 T20326 arg2Of expression,regulates
R15150 T20329 T20327 arg1Of expression,IAV-induced
R15151 T20329 T20328 arg1Of expression,gene
R15152 T20329 T20330 arg1Of expression,in
R15153 T20331 T20332 arg1Of BMDM,and
R15154 T20332 T20330 arg2Of and,in
R15155 T20334 T20332 arg2Of macrophages,and
R15156 T20334 T20333 arg1Of macrophages,alveolar
R15157 T20336 T20335 arg2Of A–B,(
R15158 T20337 T20335 arg3Of ),(
R15159 T20338 T20335 arg1Of BMDM,(
R15160 T20338 T20339 arg2Of BMDM,isolated
R15161 T20338 T20345 arg1Of BMDM,were
R15162 T20338 T20346 arg2Of BMDM,infected
R15163 T20339 T20340 arg1Of isolated,from
R15164 T20341 T20342 arg1Of A20myel-WT,and
R15165 T20343 T20342 arg2Of A20myel-KO,and
R15166 T20344 T20340 arg2Of animals,from
R15167 T20344 T20341 arg1Of animals,A20myel-WT
R15168 T20344 T20343 arg1Of animals,A20myel-KO
R15169 T20346 T20345 arg2Of infected,were
R15170 T20346 T20347 arg1Of infected,with
R15171 T20348 T20347 arg2Of IAV,with
R15172 T20348 T20349 arg1Of IAV,(
R15173 T20350 T20349 arg2Of moi,(
R15174 T20350 T20351 arg1Of moi,1
R15175 T20352 T20349 arg3Of ),(
R15176 T20357 T20353 arg2Of infection,At
R15177 T20357 T20354 arg1Of infection,different
R15178 T20357 T20355 arg1Of infection,hours
R15179 T20357 T20356 arg1Of infection,post
R15180 T20360 T20358 arg2Of p.i.,(
R15181 T20360 T20359 arg1Of p.i.,hours
R15182 T20361 T20358 arg3Of ),(
R15183 T20362 T20358 arg1Of cells,(
R15184 T20362 T20363 arg1Of cells,were
R15185 T20362 T20364 arg2Of cells,lysed
R15186 T20364 T20363 arg2Of lysed,were
R15187 T20364 T20365 arg1Of lysed,and
R15188 T20365 T20353 arg1Of and,At
R15189 T20366 T20367 arg1Of IL-6,","
R15190 T20367 T20369 arg1Of ",",and
R15191 T20368 T20367 arg2Of IFNβ,","
R15192 T20370 T20369 arg2Of A20,and
R15193 T20372 T20366 arg1Of expression,IL-6
R15194 T20372 T20368 arg1Of expression,IFNβ
R15195 T20372 T20370 arg1Of expression,A20
R15196 T20372 T20371 arg1Of expression,mRNA
R15197 T20372 T20373 arg1Of expression,was
R15198 T20372 T20374 arg2Of expression,analyzed
R15199 T20374 T20365 arg2Of analyzed,and
R15200 T20374 T20373 arg2Of analyzed,was
R15201 T20376 T20374 arg1Of qPCR,analyzed
R15202 T20376 T20375 arg2Of qPCR,by
R15203 T20376 T20377 arg1Of qPCR,(
R15204 T20378 T20377 arg2Of A,(
R15205 T20379 T20377 arg3Of ),(
R15206 T20381 T20380 arg1Of hours,18
R15207 T20381 T20382 arg2Of hours,post
R15208 T20381 T20387 arg1Of hours,was
R15209 T20381 T20388 arg2Of hours,analyzed
R15210 T20386 T20382 arg1Of supernatant,post
R15211 T20386 T20383 arg1Of supernatant,infection
R15212 T20386 T20384 arg1Of supernatant,cell
R15213 T20386 T20385 arg1Of supernatant,culture
R15214 T20388 T20387 arg2Of analyzed,was
R15215 T20388 T20389 arg1Of analyzed,for
R15216 T20390 T20391 arg1Of TNF,and
R15217 T20392 T20391 arg2Of IFNβ,and
R15218 T20394 T20389 arg2Of levels,for
R15219 T20394 T20390 arg1Of levels,TNF
R15220 T20394 T20392 arg1Of levels,IFNβ
R15221 T20394 T20393 arg1Of levels,protein
R15222 T20396 T20397 arg1Of ELISA,and
R15223 T20398 T20397 arg2Of multiplexing,and
R15224 T20399 T20388 arg1Of technologies,analyzed
R15225 T20399 T20395 arg2Of technologies,by
R15226 T20399 T20396 arg1Of technologies,ELISA
R15227 T20399 T20398 arg1Of technologies,multiplexing
R15228 T20399 T20400 arg1Of technologies,(
R15229 T20399 T20408 modOf technologies,ges
R15230 T20401 T20400 arg2Of B,(
R15231 T20402 T20400 arg3Of ),(
R15232 T20404 T20403 arg2Of (C–,.
R15233 T20405 T20403 arg3Of D,.
R15234 T20407 T20403 arg1Of ar macropha,.
R15235 T20407 T20406 arg1Of ar macropha,) Alveol
R15236 T20407 T20408 arg1Of ar macropha,ges
R15237 T20407 T20410 arg2Of ar macropha,mock tr
R15238 T20407 T20412 arg2Of ar macropha,ted or i
R15239 T20410 T20411 arg1Of mock tr,ea
R15240 T20411 T20408 arg2Of ea,ges
R15241 T20411 T20409 arg1Of ea,were
R15242 T20412 T20411 arg2Of ted or i,ea
R15243 T20412 T20413 arg1Of ted or i,nfec
R15244 T20412 T20419 arg1Of ted or i,V (
R15245 T20414 T20413 arg2Of ted,nfec
R15246 T20414 T20415 arg1Of ted,w
R15247 T20416 T20415 arg2Of ith,w
R15248 T20416 T20417 arg1Of ith,I
R15249 T20418 T20415 arg3Of A,w
R15250 T20421 T20419 arg2Of i 1) ,V (
R15251 T20421 T20420 arg1Of i 1) ,mo
R15252 T20422 T20423 arg1Of IL-6,and
R15253 T20423 T20427 arg1Of and,was
R15254 T20423 T20428 arg2Of and,determined
R15255 T20426 T20423 arg2Of expression,and
R15256 T20426 T20424 arg1Of expression,IFNβ
R15257 T20426 T20425 arg1Of expression,mRNA
R15258 T20428 T20427 arg2Of determined,was
R15259 T20430 T20428 arg1Of qPCR,determined
R15260 T20430 T20429 arg2Of qPCR,by
R15261 T20430 T20431 arg1Of qPCR,(
R15262 T20432 T20431 arg2Of C,(
R15263 T20433 T20431 arg3Of ),(
R15264 T20436 T20434 arg1Of supernatant,Cell
R15265 T20436 T20435 arg1Of supernatant,culture
R15266 T20436 T20437 arg1Of supernatant,was
R15267 T20436 T20438 arg2Of supernatant,analyzed
R15268 T20438 T20437 arg2Of analyzed,was
R15269 T20438 T20439 arg1Of analyzed,for
R15270 T20440 T20441 arg1Of IL-6,and
R15271 T20441 T20439 arg2Of and,for
R15272 T20444 T20441 arg2Of levels,and
R15273 T20444 T20442 arg1Of levels,IFNβ
R15274 T20444 T20443 arg1Of levels,protein
R15275 T20446 T20447 arg1Of ELISA,and
R15276 T20447 T20438 arg1Of and,analyzed
R15277 T20447 T20445 arg2Of and,by
R15278 T20449 T20447 arg2Of technologies,and
R15279 T20449 T20448 arg1Of technologies,multiplexing
R15280 T20449 T20450 arg1Of technologies,(
R15281 T20451 T20450 arg2Of D,(
R15282 T20452 T20450 arg3Of ),(
R15283 T20454 T20453 arg1Of bars,Error
R15284 T20454 T20455 arg1Of bars,represent
R15285 T20457 T20455 arg2Of values,represent
R15286 T20457 T20456 arg1Of values,mean
R15287 T20457 T20458 arg1Of values,(
R15288 T20457 T20462 arg1Of values,of
R15289 T20459 T20458 arg2Of +/−,(
R15290 T20460 T20459 arg2Of SEM,+/−
R15291 T20461 T20458 arg3Of ),(
R15292 T20464 T20462 arg2Of samples,of
R15293 T20464 T20463 arg1Of samples,2–3
R15294 T20465 T20466 arg1Of Results,are
R15295 T20465 T20467 arg1Of Results,representative
R15296 T20467 T20466 arg2Of representative,are
R15297 T20467 T20468 arg1Of representative,for
R15298 T20472 T20468 arg2Of ***p,for
R15299 T20472 T20469 arg1Of ***p,2
R15300 T20472 T20470 arg1Of ***p,independent
R15301 T20472 T20471 arg1Of ***p,experiments.
R15302 T20472 T20473 arg1Of ***p,<
R15303 T20473 T20474 arg1Of <,"0,001"
R15498 T20806 T20805 arg1Of deficiency,A20
R15499 T20806 T20807 arg1Of deficiency,in
R15500 T20806 T20810 arg1Of deficiency,protects
R15501 T20809 T20807 arg2Of cells,in
R15502 T20809 T20808 arg1Of cells,myeloid
R15503 T20810 T20811 arg1Of protects,against
R15504 T20814 T20811 arg2Of infection,against
R15505 T20814 T20812 arg1Of infection,IAV
R15506 T20814 T20813 arg1Of infection,lung
R15507 T20815 T20816 arg1Of A20myel-WT,and
R15508 T20817 T20816 arg2Of A20myel-KO,and
R15509 T20818 T20815 arg1Of mice,A20myel-WT
R15510 T20818 T20817 arg1Of mice,A20myel-KO
R15511 T20818 T20819 arg1Of mice,were
R15512 T20818 T20820 arg2Of mice,infected
R15513 T20820 T20819 arg2Of infected,were
R15514 T20820 T20821 arg1Of infected,intranasally
R15515 T20820 T20822 arg1Of infected,with
R15516 T20820 T20828 arg1Of infected,and
R15517 T20825 T20822 arg2Of dose,with
R15518 T20825 T20823 arg1Of dose,a
R15519 T20825 T20824 arg1Of dose,sublethal
R15520 T20825 T20826 arg1Of dose,of
R15521 T20827 T20826 arg2Of IAV,of
R15522 T20830 T20829 arg1Of loss,weight
R15523 T20830 T20831 arg1Of loss,was
R15524 T20830 T20832 arg2Of loss,monitored
R15525 T20832 T20828 arg2Of monitored,and
R15526 T20832 T20831 arg2Of monitored,was
R15527 T20832 T20833 arg1Of monitored,(
R15528 T20834 T20833 arg2Of A,(
R15529 T20835 T20833 arg3Of ),(
R15530 T20838 T20839 arg1Of 4,","
R15531 T20839 T20841 arg1Of ",",and
R15532 T20840 T20839 arg2Of 7,","
R15533 T20842 T20841 arg2Of 10,and
R15534 T20844 T20836 arg2Of infection,At
R15535 T20844 T20837 arg1Of infection,day
R15536 T20844 T20838 arg1Of infection,4
R15537 T20844 T20840 arg1Of infection,7
R15538 T20844 T20842 arg1Of infection,10
R15539 T20844 T20843 arg1Of infection,post
R15540 T20846 T20845 arg2Of p.i.,(
R15541 T20847 T20845 arg3Of ),(
R15542 T20849 T20845 arg1Of titers,(
R15543 T20849 T20848 arg1Of titers,viral
R15544 T20849 T20850 arg1Of titers,in
R15545 T20849 T20853 arg1Of titers,were
R15546 T20849 T20854 arg2Of titers,measured
R15547 T20849 T20856 arg2Of titers,expressed
R15548 T20852 T20850 arg2Of lung,in
R15549 T20852 T20851 arg1Of lung,the
R15550 T20854 T20855 arg1Of measured,and
R15551 T20855 T20836 arg1Of and,At
R15552 T20855 T20853 arg2Of and,were
R15553 T20856 T20855 arg2Of expressed,and
R15554 T20856 T20857 arg1Of expressed,as
R15555 T20859 T20857 arg2Of TCID50,as
R15556 T20859 T20858 arg1Of TCID50,mean
R15557 T20859 T20860 arg1Of TCID50,(
R15558 T20861 T20860 arg2Of B,(
R15559 T20862 T20860 arg3Of ),(
R15560 T20865 T20863 arg1Of line,The
R15561 T20865 T20864 arg1Of line,dashed
R15562 T20865 T20866 arg1Of line,represents
R15563 T20869 T20866 arg2Of limit,represents
R15564 T20869 T20867 arg1Of limit,the
R15565 T20869 T20868 arg1Of limit,detection
R15566 T20870 T20871 arg1Of ND,","
R15567 T20870 T20873 arg1Of ND,detectable
R15568 T20873 T20872 arg1Of detectable,not
R15569 T20874 T20875 arg1Of BAL,was
R15570 T20874 T20876 arg2Of BAL,isolated
R15571 T20876 T20875 arg2Of isolated,was
R15572 T20876 T20877 arg1Of isolated,from
R15573 T20876 T20881 arg1Of isolated,at
R15574 T20876 T20883 arg1Of isolated,","
R15575 T20880 T20877 arg2Of mice,from
R15576 T20880 T20878 arg1Of mice,IAV
R15577 T20880 T20879 arg1Of mice,infected
R15578 T20882 T20881 arg2Of 4,at
R15579 T20884 T20885 arg1Of 7,and
R15580 T20886 T20885 arg2Of 10,and
R15581 T20888 T20884 arg1Of p.i.,7
R15582 T20888 T20886 arg1Of p.i.,10
R15583 T20888 T20887 arg1Of p.i.,days
R15584 T20888 T20889 arg1Of p.i.,and
R15585 T20889 T20901 arg1Of and,were
R15586 T20889 T20902 arg2Of and,analyzed
R15587 T20890 T20891 arg1Of KC,","
R15588 T20891 T20893 arg1Of ",",","
R15589 T20892 T20891 arg2Of MIP-2,","
R15590 T20893 T20895 arg1Of ",",","
R15591 T20894 T20893 arg2Of MCP-1,","
R15592 T20895 T20897 arg1Of ",",and
R15593 T20896 T20895 arg2Of IL-6,","
R15594 T20897 T20889 arg2Of and,and
R15595 T20900 T20897 arg2Of levels,and
R15596 T20900 T20898 arg1Of levels,IFNα
R15597 T20900 T20899 arg1Of levels,protein
R15598 T20902 T20883 arg2Of analyzed,","
R15599 T20902 T20901 arg2Of analyzed,were
R15600 T20904 T20905 arg1Of ELISA,and
R15601 T20906 T20905 arg2Of multiplexing,and
R15602 T20907 T20902 arg1Of technologies,analyzed
R15603 T20907 T20903 arg2Of technologies,by
R15604 T20907 T20904 arg1Of technologies,ELISA
R15605 T20907 T20906 arg1Of technologies,multiplexing
R15606 T20907 T20908 arg1Of technologies,(
R15607 T20909 T20908 arg2Of C,(
R15608 T20910 T20908 arg3Of ),(
R15609 T20912 T20911 arg1Of numbers,Absolute
R15610 T20912 T20913 arg1Of numbers,of
R15611 T20912 T20923 arg1Of numbers,were
R15612 T20912 T20924 arg2Of numbers,analyzed
R15613 T20916 T20917 arg1Of macrophages,","
R15614 T20917 T20919 arg1Of ",",and
R15615 T20918 T20917 arg2Of neutrophils,","
R15616 T20919 T20913 arg2Of and,of
R15617 T20919 T20914 arg1Of and,resident
R15618 T20919 T20915 arg1Of and,alveolar
R15619 T20919 T20921 arg1Of and,in
R15620 T20920 T20919 arg2Of monocytes,and
R15621 T20922 T20921 arg2Of BAL,in
R15622 T20924 T20923 arg2Of analyzed,were
R15623 T20924 T20928 arg1Of analyzed,at
R15624 T20927 T20924 arg1Of cytometry,analyzed
R15625 T20927 T20925 arg2Of cytometry,by
R15626 T20927 T20926 arg1Of cytometry,flow
R15627 T20929 T20930 arg1Of 4,","
R15628 T20930 T20932 arg1Of ",",and
R15629 T20931 T20930 arg2Of 7,","
R15630 T20933 T20932 arg2Of 10,and
R15631 T20935 T20928 arg2Of p.i.,at
R15632 T20935 T20929 arg1Of p.i.,4
R15633 T20935 T20931 arg1Of p.i.,7
R15634 T20935 T20933 arg1Of p.i.,10
R15635 T20935 T20934 arg1Of p.i.,days
R15636 T20935 T20936 arg1Of p.i.,(
R15637 T20937 T20936 arg2Of D,(
R15638 T20938 T20936 arg3Of ),(
R15639 T20939 T20940 arg1Of Numbers,are
R15640 T20939 T20952 arg1Of Numbers,are
R15641 T20939 T20953 arg1Of Numbers,representative
R15642 T20940 T20951 arg1Of are,and
R15643 T20941 T20942 arg1Of averages,+/−
R15644 T20942 T20940 arg2Of +/−,are
R15645 T20942 T20944 arg1Of +/−,of
R15646 T20943 T20942 arg2Of SEM,+/−
R15647 T20947 T20945 arg1Of 5,at
R15648 T20947 T20946 arg1Of 5,least
R15649 T20948 T20944 arg2Of mice,of
R15650 T20948 T20947 arg1Of mice,5
R15651 T20948 T20949 arg1Of mice,per
R15652 T20950 T20949 arg2Of group,per
R15653 T20952 T20951 arg2Of are,and
R15654 T20953 T20952 arg2Of representative,are
R15655 T20953 T20954 arg1Of representative,of
R15656 T20960 T20954 arg2Of 0.05,of
R15657 T20960 T20955 arg1Of 0.05,2
R15658 T20960 T20956 arg1Of 0.05,independent
R15659 T20960 T20957 arg1Of 0.05,experiments.
R15660 T20960 T20958 arg1Of 0.05,*p
R15661 T20960 T20959 arg1Of 0.05,<
R15662 T20960 T20961 arg1Of 0.05,;
R15663 T20964 T20961 arg2Of 0.01,;
R15664 T20964 T20962 arg1Of 0.01,**p
R15665 T20964 T20963 arg1Of 0.01,<
R15845 T21247 T21246 arg1Of deficiency,A20
R15846 T21247 T21248 arg1Of deficiency,in
R15847 T21247 T21251 arg1Of deficiency,protects
R15848 T21250 T21248 arg2Of cells,in
R15849 T21250 T21249 arg1Of cells,myeloid
R15850 T21251 T21252 arg1Of protects,against
R15851 T21255 T21252 arg2Of infection,against
R15852 T21255 T21253 arg1Of infection,lethal
R15853 T21255 T21254 arg1Of infection,IAV
R15854 T21256 T21257 arg1Of A20myel-WT,(
R15855 T21256 T21260 arg1Of A20myel-WT,and
R15856 T21258 T21257 arg2Of n = 11,(
R15857 T21259 T21257 arg3Of ),(
R15858 T21260 T21266 modOf and,were
R15859 T21260 T21285 arg1Of and,and
R15860 T21261 T21260 arg2Of A20myel-KO,and
R15861 T21261 T21262 arg1Of A20myel-KO,(
R15862 T21263 T21262 arg2Of n = 11,(
R15863 T21264 T21262 arg3Of ),(
R15864 T21265 T21266 arg1Of mice,were
R15865 T21265 T21268 arg2Of mice,infected
R15866 T21268 T21266 arg2Of infected,were
R15867 T21268 T21267 arg1Of infected,intranasally
R15868 T21268 T21269 arg1Of infected,with
R15869 T21272 T21269 arg2Of dose,with
R15870 T21272 T21270 arg1Of dose,a
R15871 T21272 T21271 arg1Of dose,lethal
R15872 T21272 T21273 arg1Of dose,of
R15873 T21272 T21277 arg1Of dose,(
R15874 T21272 T21282 arg1Of dose,(
R15875 T21274 T21275 arg1Of IAV,and
R15876 T21275 T21273 arg2Of and,of
R15877 T21276 T21275 arg2Of survival,and
R15878 T21278 T21277 arg2Of p,(
R15879 T21278 T21279 arg1Of p,<
R15880 T21278 T21280 arg1Of p,0.001
R15881 T21281 T21277 arg3Of ),(
R15882 T21283 T21282 arg2Of A,(
R15883 T21284 T21282 arg3Of ),(
R15884 T21285 T21293 arg1Of and,was
R15885 T21285 T21294 arg2Of and,monitored
R15886 T21287 T21286 arg1Of loss,weight
R15887 T21287 T21288 arg1Of loss,+/−
R15888 T21288 T21285 arg2Of +/−,and
R15889 T21289 T21288 arg2Of SEM,+/−
R15890 T21289 T21290 arg1Of SEM,(
R15891 T21291 T21290 arg2Of B,(
R15892 T21292 T21290 arg3Of ),(
R15893 T21294 T21293 arg2Of monitored,was
R15894 T21294 T21295 arg1Of monitored,for
R15895 T21297 T21298 arg1Of 21,and
R15896 T21299 T21298 arg2Of 15,and
R15897 T21301 T21295 arg2Of p.i,for
R15898 T21301 T21296 arg1Of p.i,respectively
R15899 T21301 T21297 arg1Of p.i,21
R15900 T21301 T21299 arg1Of p.i,15
R15901 T21301 T21300 arg1Of p.i,days
R15902 T21303 T21302 arg1Of fluid,BAL
R15903 T21303 T21304 arg1Of fluid,was
R15904 T21303 T21305 arg2Of fluid,collected
R15905 T21305 T21304 arg2Of collected,was
R15906 T21305 T21306 arg1Of collected,from
R15907 T21308 T21309 arg1Of type,(
R15908 T21308 T21312 arg1Of type,and
R15909 T21310 T21309 arg2Of A20myel-WT,(
R15910 T21311 T21309 arg3Of ),(
R15911 T21313 T21312 arg2Of A20myel-KO,and
R15912 T21314 T21306 arg2Of mice,from
R15913 T21314 T21307 arg1Of mice,wild
R15914 T21314 T21308 arg1Of mice,type
R15915 T21314 T21313 arg1Of mice,A20myel-KO
R15916 T21316 T21315 arg1Of days,6
R15917 T21316 T21317 arg1Of days,following
R15918 T21316 T21336 arg1Of days,were
R15919 T21316 T21337 arg2Of days,determined
R15920 T21318 T21319 arg1Of infection,with
R15921 T21318 T21324 arg1Of infection,and
R15922 T21323 T21319 arg2Of IAV,with
R15923 T21323 T21320 arg1Of IAV,a
R15924 T21323 T21321 arg1Of IAV,lethal
R15925 T21323 T21322 arg1Of IAV,dose
R15926 T21324 T21317 arg2Of and,following
R15927 T21325 T21326 arg1Of KC,","
R15928 T21326 T21328 arg1Of ",",","
R15929 T21327 T21326 arg2Of MIP-2,","
R15930 T21328 T21330 arg1Of ",",","
R15931 T21329 T21328 arg2Of MCP-1,","
R15932 T21330 T21332 arg1Of ",",and
R15933 T21331 T21330 arg2Of IL-6,","
R15934 T21332 T21324 arg2Of and,and
R15935 T21335 T21332 arg2Of levels,and
R15936 T21335 T21333 arg1Of levels,IFNα
R15937 T21335 T21334 arg1Of levels,protein
R15938 T21337 T21304 modOf determined,was
R15939 T21337 T21336 arg2Of determined,were
R15940 T21337 T21338 arg1Of determined,(
R15941 T21339 T21338 arg2Of C,(
R15942 T21340 T21338 arg3Of ),(
R15943 T21342 T21341 arg1Of numbers,Absolute
R15944 T21342 T21343 arg1Of numbers,of
R15945 T21342 T21352 arg1Of numbers,were
R15946 T21342 T21353 arg2Of numbers,analyzed
R15947 T21345 T21346 arg1Of macrophages,","
R15948 T21346 T21348 arg1Of ",",and
R15949 T21347 T21346 arg2Of neutrophils,","
R15950 T21348 T21343 arg2Of and,of
R15951 T21348 T21344 arg1Of and,alveolar
R15952 T21348 T21350 arg1Of and,in
R15953 T21349 T21348 arg2Of monocytes,and
R15954 T21351 T21350 arg2Of BAL,in
R15955 T21353 T21352 arg2Of analyzed,were
R15956 T21356 T21353 arg1Of cytometry,analyzed
R15957 T21356 T21354 arg2Of cytometry,by
R15958 T21356 T21355 arg1Of cytometry,flow
R15959 T21356 T21357 arg1Of cytometry,at
R15960 T21360 T21357 arg2Of p.i.,at
R15961 T21360 T21358 arg1Of p.i.,6
R15962 T21360 T21359 arg1Of p.i.,days
R15963 T21360 T21361 arg1Of p.i.,(
R15964 T21362 T21361 arg2Of D,(
R15965 T21363 T21361 arg3Of ),(
R15966 T21364 T21365 arg1Of Numbers,are
R15967 T21366 T21367 arg1Of averages,+/−
R15968 T21367 T21365 arg2Of +/−,are
R15969 T21367 T21369 arg1Of +/−,of
R15970 T21368 T21367 arg2Of SEM,+/−
R15971 T21372 T21370 arg1Of 5,at
R15972 T21372 T21371 arg1Of 5,least
R15973 T21373 T21369 arg2Of mice,of
R15974 T21373 T21372 arg1Of mice,5
R15975 T21373 T21374 arg1Of mice,per
R15976 T21375 T21374 arg2Of group,per
R15977 T21376 T21377 arg1Of Data,are
R15978 T21376 T21378 arg1Of Data,representative
R15979 T21378 T21377 arg2Of representative,are
R15980 T21378 T21379 arg1Of representative,of
R15981 T21382 T21380 arg1Of experiments.,2
R15982 T21382 T21381 arg1Of experiments.,independent
R15983 T21382 T21383 arg1Of experiments.,*p
R15984 T21382 T21386 arg1Of experiments.,;
R15985 T21385 T21383 arg2Of 0.05,*p
R15986 T21385 T21384 arg1Of 0.05,<
R15987 T21389 T21386 arg2Of 0.01,;
R15988 T21389 T21387 arg1Of 0.01,**p
R15989 T21389 T21388 arg1Of 0.01,<
R15990 T21389 T21390 arg1Of 0.01,","
R15991 T21391 T21390 arg2Of ***p,","
R15992 T21391 T21392 arg1Of ***p,<
R15993 T21393 T21379 arg2Of 0.001,of
R15994 T21393 T21382 arg1Of 0.001,experiments.
R3407 T5161 T5193 arg1Of activation,(
R3442 T5188 T5189 arg1Of RIG-I,(
R3444 T5190 T5189 arg2Of 2CARD,(
R3445 T5191 T5189 arg3Of ),(
R3446 T5192 T5187 arg3Of ],[
R3447 T5195 T5194 arg1Of 1A,figure
R3448 T5195 T5196 arg1Of 1A,","
R3449 T5196 T5193 arg2Of ",",(
R3450 T5197 T5198 arg1Of left,and
R3451 T5199 T5198 arg2Of middle,and
R3452 T5200 T5196 arg2Of graph,","
R3453 T5200 T5197 arg1Of graph,left
R3454 T5200 T5199 arg1Of graph,middle
R3455 T5201 T5193 arg3Of ),(
R3456 T5202 T5204 arg1Of We,investigated
R3457 T5204 T5203 arg1Of investigated,next
R3458 T5206 T5208 arg1Of A20,inhibits
R3459 T5208 T5204 arg2Of inhibits,investigated
R3460 T5208 T5205 arg1Of inhibits,whether
R3461 T5208 T5207 arg1Of inhibits,also
R3677 T5424 T5440 arg1Of Crossing,leads
R8532 T12002 T11999 arg2Of study,In
R8533 T12002 T12000 arg1Of study,the
R8537 T12005 T11999 arg1Of investigated,In
R3400 T5150 T5149 arg1Of overexpression,A20
R3401 T5150 T5151 arg1Of overexpression,in
R3402 T5150 T5154 arg1Of overexpression,prevents
R3403 T5153 T5151 arg2Of cells,in
R3404 T5153 T5152 arg1Of cells,HEK293T
R3408 T5161 T5154 arg2Of activation,prevents
R3409 T5161 T5155 arg1Of activation,NF-κB-
R3410 T5161 T5156 arg1Of activation,and
R3411 T5161 T5157 arg1Of activation,IRF3-dependent
R3412 T5161 T5158 arg1Of activation,luciferase
R3413 T5161 T5159 arg1Of activation,reporter
R3414 T5161 T5160 arg1Of activation,gene
R3415 T5161 T5162 arg2Of activation,induced
R3416 T5161 T5177 arg1Of activation,corresponding
R3417 T5162 T5176 arg1Of induced,","
R3418 T5162 T5177 modOf induced,corresponding
R3419 T5164 T5162 arg1Of transfection,induced
R3420 T5164 T5163 arg2Of transfection,by
R3421 T5164 T5165 arg1Of transfection,of
R3422 T5169 T5168 arg1Of active,constitutive
R3423 T5170 T5165 arg2Of form,of
R3424 T5170 T5166 arg1Of form,a
R3425 T5170 T5167 arg2Of form,truncated
R3426 T5170 T5169 arg1Of form,active
R3427 T5170 T5171 arg1Of form,of
R3428 T5172 T5171 arg2Of RIG-I,of
R3429 T5172 T5173 arg1Of RIG-I,[
R3430 T5174 T5173 arg2Of 53,[
R3431 T5175 T5173 arg3Of ],[
R3432 T5177 T5178 arg1Of corresponding,to
R3433 T5184 T5178 arg2Of domains,to
R3434 T5184 T5179 arg1Of domains,only
R3435 T5184 T5180 arg1Of domains,the
R3436 T5184 T5181 arg1Of domains,two
R3437 T5184 T5182 arg1Of domains,N-terminal
R3438 T5184 T5183 arg1Of domains,CARD
R3439 T5184 T5185 arg1Of domains,of
R3440 T5184 T5187 arg1Of domains,[

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T4891 14142-14146 Antecedent denotes IRF3
T4890 14297-14300 Anaphor denotes its
T4889 10587-10597 Antecedent denotes luciferase
T4888 10780-10793 Anaphor denotes reporter gene
T11814 29643-29647 Antecedent denotes IKKε
T11813 29634-29638 Antecedent denotes TBK1
T11812 29732-29737 Anaphor denotes their
T11811 29413-29417 Antecedent denotes IKKε
T11810 29404-29408 Antecedent denotes TBK1
T11809 29423-29428 Anaphor denotes their
T1029 5797-5801 Antecedent denotes MAVS
T1028 5853-5858 Anaphor denotes which
R8525 T11809 T11810 boundBy their,TBK1
R8526 T11809 T11811 boundBy their,IKKε
R8527 T11812 T11813 boundBy their,TBK1
R8528 T11812 T11814 boundBy their,IKKε
R3328 T4888 T4889 boundBy reporter gene,luciferase
R3329 T4890 T4891 boundBy its,IRF3
R593 T1028 T1029 boundBy which,MAVS

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T20794 19427-19431 Protein denotes IL-6
T20793 19420-19425 Protein denotes MCP-1
T20792 19413-19418 Protein denotes MIP-2
T20791 19409-19411 Protein denotes KC
T19404 12335-12339 Protein denotes IFNβ
T19403 12327-12330 Protein denotes TNF
T19402 12310-12314 Protein denotes IL-6
T19401 12229-12233 Protein denotes IFNβ
T19400 12221-12224 Protein denotes TNF
T19399 12215-12219 Protein denotes IL-6
T19398 12116-12120 Protein denotes IRF3
T18287 40135-40139 Protein denotes IL-6
T18286 40125-40130 Protein denotes IL-1β
T18285 40120-40123 Protein denotes TNF
T18284 40116-40118 Protein denotes KC
T18283 40109-40114 Protein denotes MCP-1
T18282 39891-39895 Protein denotes IFNβ
T18281 39800-39803 Protein denotes TNF
T18280 39757-39760 Protein denotes TNF
T16554 36552-36556 Protein denotes IRF7
T16553 36546-36550 Protein denotes IRF3
T16132 35946-35949 Protein denotes CD8
T16131 35937-35940 Protein denotes CD3
T16130 35876-35879 Protein denotes CD8
T16129 35482-35485 Protein denotes CD8
T7760 17190-17194 Protein denotes IFNβ
T7759 17170-17173 Protein denotes TNF
T7758 17161-17165 Protein denotes IL-6
T7757 15814-15818 Protein denotes IFNβ
T7756 15806-15809 Protein denotes TNF
T7755 15627-15631 Protein denotes IFNβ
T7754 15618-15622 Protein denotes IL-6
T7767 17606-17610 Protein denotes IRF3
T7766 17582-17587 Protein denotes RIG-I
T7765 17245-17250 Protein denotes cxcl1
T7764 17241-17243 Protein denotes KC
T7763 17231-17235 Protein denotes ccl2
T7762 17224-17229 Protein denotes MCP-1
T7761 17199-17204 Protein denotes IFNα4
T4944 15168-15172 Protein denotes IRF3
T4943 15144-15149 Protein denotes RIG-I
T4942 14950-14954 Protein denotes IFNβ
T4941 14942-14945 Protein denotes TNF
T4940 14936-14940 Protein denotes IL-6
T4939 14865-14869 Protein denotes IRF3
T4938 14809-14813 Protein denotes IFNβ
T4937 14778-14782 Protein denotes IRF3
T4936 14759-14762 Protein denotes TNF
T4935 14750-14754 Protein denotes IL-6
T4934 14582-14586 Protein denotes IRF3
T4933 14577-14580 Protein denotes p65
T4932 14450-14454 Protein denotes IRF3
T4931 14275-14279 Protein denotes IKKε
T4930 14266-14270 Protein denotes TBK1
T4929 14142-14146 Protein denotes IRF3
T4928 13986-13989 Protein denotes p65
T4927 13926-13930 Protein denotes IκBα
T4926 13416-13420 Protein denotes IRF3
T4925 13391-13395 Protein denotes TLR3
T4924 13306-13310 Protein denotes MDA5
T4923 13288-13293 Protein denotes RIG-I
T4922 13100-13105 Protein denotes RIG-I
T4921 12505-12510 Protein denotes RIG-I
T4920 11068-11069 Protein denotes 7
T4919 11063-11067 Protein denotes IRF3
T4918 11039-11044 Protein denotes RIG-I
T4917 10939-10943 Protein denotes IRF7
T4916 10925-10930 Protein denotes RIG-I
T4915 10889-10893 Protein denotes IRF3
T4914 10837-10841 Protein denotes IRF7
T4913 10661-10665 Protein denotes IRF7
T4912 10587-10597 Protein denotes luciferase
T4911 10567-10571 Protein denotes IRF7
T4910 10485-10489 Protein denotes IRF7
T4909 10423-10427 Protein denotes IRF7
T4908 10361-10365 Protein denotes IRF3
T4907 10298-10302 Protein denotes IRF7
T4906 10239-10243 Protein denotes IRF7
T4905 10233-10237 Protein denotes IRF3
T4904 10209-10213 Protein denotes IRF7
T4903 10104-10109 Protein denotes RIG-I
T4902 10035-10040 Protein denotes RIG-I
T4901 9997-10031 Protein denotes truncated constitutive active form
T4900 9932-9942 Protein denotes luciferase
T4899 9917-9921 Protein denotes IRF3
T4898 9808-9813 Protein denotes RIG-I
T4897 9787-9791 Protein denotes IRF3
T4896 9554-9558 Protein denotes IRF7
T4895 9545-9549 Protein denotes IRF3
T4894 9496-9501 Protein denotes RIG-I
T4893 9480-9484 Protein denotes IRF3
T4892 9456-9461 Protein denotes RIG-I
T1085 8527-8532 Protein denotes IRF-3
T1084 8491-8495 Protein denotes TLR3
T1083 8480-8485 Protein denotes RIG-I
T1082 7531-7536 Protein denotes IL-1R
T1081 7516-7520 Protein denotes TLR4
T1080 7490-7504 Protein denotes TNF receptor I
T1079 7062-7067 Protein denotes RBCK1
T1078 7046-7052 Protein denotes TRIM21
T1077 7035-7039 Protein denotes RAUL
T1076 6993-6997 Protein denotes IRF7
T1075 6984-6988 Protein denotes IRF3
T1074 6822-6827 Protein denotes TRAF3
T1073 6813-6817 Protein denotes MAVS
T1072 6782-6789 Protein denotes TRIAD3A
T1071 6768-6772 Protein denotes AIP4
T1070 6602-6605 Protein denotes RLR
T1069 6530-6534 Protein denotes CYLD
T1068 6519-6523 Protein denotes DUBA
T1067 6440-6445 Protein denotes RIG-I
T1066 6419-6423 Protein denotes IRF3
T1065 6377-6382 Protein denotes TRAF3
T1064 6356-6361 Protein denotes TRAF6
T1063 6280-6285 Protein denotes RIG-I
T1062 6225-6231 Protein denotes Riplet
T1061 6209-6215 Protein denotes TRIM25
T1060 6122-6127 Protein denotes RIG-I
T1059 6011-6015 Protein denotes MAVS
T1058 5828-5834 Protein denotes Cardif
T1057 5822-5826 Protein denotes VISA
T1056 5815-5820 Protein denotes IPS-1
T1055 5797-5801 Protein denotes MAVS
T1054 5753-5758 Protein denotes RIG-I
T1053 5581-5586 Protein denotes RIG-I
T1052 5330-5334 Protein denotes TLR3
T1051 5259-5264 Protein denotes RIG-I
T1050 5213-5218 Protein denotes RIG-I
T1049 5003-5008 Protein denotes RIG-I
T1048 4994-4998 Protein denotes TLR3
T40 5-12 Protein denotes Tnfaip3
T19397 12108-12111 Protein denotes p65
T19396 11988-11992 Protein denotes IRF3
T19395 11979-11982 Protein denotes p65
T19394 11748-11752 Protein denotes IRF3
T19393 11706-11710 Protein denotes IκBα
T19392 11372-11376 Protein denotes IRF7
T19391 11285-11295 Protein denotes luciferase
T19390 11270-11274 Protein denotes IRF7
T19389 11253-11257 Protein denotes IRF3
T19388 11180-11185 Protein denotes RIG-I
T19387 11149-11153 Protein denotes IRF3
T18680 41106-41111 Protein denotes IFNα4
T18679 41037-41042 Protein denotes CXCL1
T18678 40966-40970 Protein denotes CCL2
T18677 40900-40903 Protein denotes A20
T18676 40831-40835 Protein denotes IFNβ
T18675 40759-40763 Protein denotes IL-6
T17847 39523-39527 Protein denotes CD16
T17846 39495-39499 Protein denotes IFNγ
T17845 39474-39478 Protein denotes CD8α
T17844 39436-39440 Protein denotes Ly6G
T17843 39366-39369 Protein denotes CD3
T17842 39321-39331 Protein denotes Granzyme B
T17841 39302-39307 Protein denotes CD62L
T17840 38886-38905 Protein denotes collagenase type IV
T8813 24148-24153 Protein denotes MCP-1
T8812 23964-23969 Protein denotes IL-1β
T8811 23956-23959 Protein denotes TNF
T8810 23950-23954 Protein denotes IL-6
T8809 23683-23688 Protein denotes MIP-2
T8808 23676-23678 Protein denotes KC
T8807 21991-21994 Protein denotes GrB
T8806 21675-21678 Protein denotes GrB
T8805 21663-21673 Protein denotes Granzyme B
T8804 21267-21272 Protein denotes F4/80
T8803 21168-21173 Protein denotes MCP-1
T8802 20759-20764 Protein denotes F4/80
T8801 20680-20685 Protein denotes MIP-2
T8800 20673-20675 Protein denotes KC
T8799 20507-20512 Protein denotes MCP-1
T8798 20457-20462 Protein denotes MIP-2
T8797 20427-20431 Protein denotes IL-8
T8796 20396-20398 Protein denotes KC
T8795 20323-20328 Protein denotes MCP-1
T8794 20069-20073 Protein denotes IL-6
T8793 20040-20045 Protein denotes MIP-2
T8792 20033-20035 Protein denotes KC
T21234 25084-25088 Protein denotes IFNα
T21233 25075-25079 Protein denotes IL-6
T21232 25068-25073 Protein denotes MCP-1
T21231 25061-25066 Protein denotes MIP-2
T21230 25057-25059 Protein denotes KC
T1033 3304-3316 Protein denotes interferon-α
T1032 3274-3278 Protein denotes IL-1
T1031 3265-3269 Protein denotes IL-6
T1030 3260-3263 Protein denotes TNF
T16128 35457-35460 Protein denotes GrB
T16127 35445-35455 Protein denotes Granzyme B
T16126 35432-35435 Protein denotes CD8
T16125 35397-35400 Protein denotes GrB
T11844 30465-30470 Protein denotes RIG-I
T11843 30172-30177 Protein denotes IRF-3
T11842 30143-30148 Protein denotes RIG-I
T11841 30055-30059 Protein denotes CYLD
T11840 29853-29857 Protein denotes IRF3
T11839 29643-29647 Protein denotes IKKε
T11838 29634-29638 Protein denotes TBK1
T11837 29527-29532 Protein denotes RIG-I
T11836 29449-29453 Protein denotes IRF3
T11835 29413-29417 Protein denotes IKKε
T11834 29404-29408 Protein denotes TBK1
T11833 29300-29305 Protein denotes ABIN1
T11832 29089-29093 Protein denotes IRF3
T11831 28836-28840 Protein denotes IRF3
T11830 28795-28799 Protein denotes IFNβ
T11829 28784-28789 Protein denotes MIP-2
T11828 28780-28782 Protein denotes KC
T11827 28774-28778 Protein denotes IL-6
T11826 28769-28772 Protein denotes TNF
T11825 28647-28652 Protein denotes RIG-I
T11824 28448-28453 Protein denotes RIG-I
T11823 28392-28397 Protein denotes RIG-I
T11822 28361-28365 Protein denotes IRF3
T11821 27331-27336 Protein denotes MCP-1
T11820 27169-27174 Protein denotes MCP-1
T11819 26750-26755 Protein denotes IL-1β
T11818 26742-26745 Protein denotes TNF
T11817 26736-26740 Protein denotes IL-6
T11816 26684-26689 Protein denotes MIP-2
T11815 26677-26679 Protein denotes KC
T20306 16518-16522 Protein denotes IFNβ
T20305 16509-16513 Protein denotes IL-6
T20304 16418-16422 Protein denotes IFNβ
T20303 16409-16413 Protein denotes IL-6
T20302 16257-16261 Protein denotes IFNβ
T20301 16249-16252 Protein denotes TNF
T20300 16128-16132 Protein denotes IFNβ
T20299 16122-16126 Protein denotes IL-6
T41 433-462 Protein denotes pathogen recognition receptor
T42 463-468 Protein denotes RIG-I
T43 992-996 Protein denotes IRF3
T1041 3867-3871 Protein denotes TLR3
T1040 3837-3841 Protein denotes Nod2
T1039 3831-3835 Protein denotes TLR8
T1038 3825-3829 Protein denotes TLR7
T1037 3461-3465 Protein denotes IRF7
T1036 3452-3456 Protein denotes IRF3
T1035 3329-3334 Protein denotes IFN-β
T1034 3318-3323 Protein denotes IFN-α
T1047 4054-4059 Protein denotes IFI16
T1046 4031-4035 Protein denotes AIM2
T1045 3982-3985 Protein denotes DAI
T1044 3976-3980 Protein denotes TLR9
T1043 3880-3884 Protein denotes MDA5
T1042 3873-3878 Protein denotes RIG-I

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T535 0-3 http://www.uniprot.org/uniprot/P21580 denotes A20
T21144 19427-19431 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T21143 19413-19418 http://www.uniprot.org/uniprot/P10889 denotes MIP-2
T21142 18967-18970 http://www.uniprot.org/uniprot/P21580 denotes A20
T21566 25075-25079 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T21565 25061-25066 http://www.uniprot.org/uniprot/P10889 denotes MIP-2
T21564 24652-24655 http://www.uniprot.org/uniprot/P21580 denotes A20
T20647 16249-16252 http://www.uniprot.org/uniprot/P01375 denotes TNF
T20646 16509-16513 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T20645 16409-16413 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T20644 16122-16126 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T20643 16137-16140 http://www.uniprot.org/uniprot/P21580 denotes A20
T20642 15876-15879 http://www.uniprot.org/uniprot/P21580 denotes A20
T19995 12327-12330 http://www.uniprot.org/uniprot/P01375 denotes TNF
T19994 12221-12224 http://www.uniprot.org/uniprot/P01375 denotes TNF
T19993 12310-12314 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T19992 12215-12219 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T19991 12108-12111 http://www.uniprot.org/uniprot/P21579 denotes p65
T19990 11979-11982 http://www.uniprot.org/uniprot/P21579 denotes p65
T19989 12108-12111 http://www.uniprot.org/uniprot/Q04206 denotes p65
T19988 11979-11982 http://www.uniprot.org/uniprot/Q04206 denotes p65
T19987 11872-11876 http://www.uniprot.org/uniprot/P25963 denotes IκBα
T19986 11706-11710 http://www.uniprot.org/uniprot/P25963 denotes IκBα
T19985 11416-11426 http://www.uniprot.org/uniprot/P08659 denotes Luciferase
T19984 11285-11295 http://www.uniprot.org/uniprot/P08659 denotes luciferase
T19983 11372-11376 http://www.uniprot.org/uniprot/Q92985 denotes IRF7
T19982 11270-11274 http://www.uniprot.org/uniprot/Q92985 denotes IRF7
T19981 12116-12120 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T19980 11988-11992 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T19979 11748-11752 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T19978 11253-11257 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T19977 11149-11153 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T19976 11411-11414 http://www.uniprot.org/uniprot/P21580 denotes A20
T19975 11126-11129 http://www.uniprot.org/uniprot/P21580 denotes A20
T19026 40900-40903 http://www.uniprot.org/uniprot/P21580 denotes A20
T19025 40759-40763 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T18532 40310-40315 http://www.uniprot.org/uniprot/P10889 denotes MIP-2
T18531 40135-40139 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T18530 40125-40130 http://www.uniprot.org/uniprot/P01584 denotes IL-1β
T18529 40120-40123 http://www.uniprot.org/uniprot/P01375 denotes TNF
T18528 39800-39803 http://www.uniprot.org/uniprot/P01375 denotes TNF
T18527 39757-39760 http://www.uniprot.org/uniprot/P01375 denotes TNF
T18149 39366-39369 http://www.uniprot.org/uniprot/P09693 denotes CD3
T18148 39366-39369 http://www.uniprot.org/uniprot/P07766 denotes CD3
T18147 39366-39369 http://www.uniprot.org/uniprot/P04234 denotes CD3
T18146 39366-39369 http://www.uniprot.org/uniprot/P20963 denotes CD3
T18145 39302-39307 http://www.uniprot.org/uniprot/P14151 denotes CD62L
T17081 37125-37128 http://www.uniprot.org/uniprot/P04141 denotes CSF
T17080 37123-37128 http://www.uniprot.org/uniprot/P09603 denotes M-CSF
T17079 36546-36550 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T17078 36552-36556 http://www.uniprot.org/uniprot/Q92985 denotes IRF7
T17077 36423-36428 http://www.uniprot.org/uniprot/Q92985 denotes IRF-7
T17723 38562-38566 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T17722 38530-38534 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T17721 38487-38490 http://www.uniprot.org/uniprot/P21579 denotes p65
T17720 38487-38490 http://www.uniprot.org/uniprot/Q04206 denotes p65
T16416 35937-35940 http://www.uniprot.org/uniprot/P09693 denotes CD3
T16415 35937-35940 http://www.uniprot.org/uniprot/P07766 denotes CD3
T16414 35937-35940 http://www.uniprot.org/uniprot/P04234 denotes CD3
T16413 35937-35940 http://www.uniprot.org/uniprot/P20963 denotes CD3
T16412 35946-35949 http://www.uniprot.org/uniprot/P10966 denotes CD8
T16411 35876-35879 http://www.uniprot.org/uniprot/P10966 denotes CD8
T16410 35482-35485 http://www.uniprot.org/uniprot/P10966 denotes CD8
T16409 35432-35435 http://www.uniprot.org/uniprot/P10966 denotes CD8
T16408 35946-35949 http://www.uniprot.org/uniprot/P01732 denotes CD8
T16407 35876-35879 http://www.uniprot.org/uniprot/P01732 denotes CD8
T16406 35482-35485 http://www.uniprot.org/uniprot/P01732 denotes CD8
T16405 35432-35435 http://www.uniprot.org/uniprot/P01732 denotes CD8
T14982 32469-32471 http://www.uniprot.org/uniprot/P41134 denotes ID
T14295 29634-29638 http://www.uniprot.org/uniprot/Q9UHD2 denotes TBK1
T14294 29404-29408 http://www.uniprot.org/uniprot/Q9UHD2 denotes TBK1
T14293 29330-29334 http://www.uniprot.org/uniprot/Q9UHD2 denotes TBK1
T14292 29324-29329 http://www.uniprot.org/uniprot/Q13114 denotes TRAF3
T14291 29288-29295 http://www.uniprot.org/uniprot/Q86VP1 denotes TAX1BP1
T14290 30172-30177 http://www.uniprot.org/uniprot/Q14653 denotes IRF-3
T14289 29853-29857 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T14288 29449-29453 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T14287 29089-29093 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T14286 28836-28840 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T14285 28361-28365 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T14284 26750-26755 http://www.uniprot.org/uniprot/P01584 denotes IL-1β
T14283 28769-28772 http://www.uniprot.org/uniprot/P01375 denotes TNF
T14282 26742-26745 http://www.uniprot.org/uniprot/P01375 denotes TNF
T14281 28774-28778 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T14280 26736-26740 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T14279 28784-28789 http://www.uniprot.org/uniprot/P10889 denotes MIP-2
T14278 26684-26689 http://www.uniprot.org/uniprot/P10889 denotes MIP-2
T14277 32002-32005 http://www.uniprot.org/uniprot/P21580 denotes A20
T14276 31931-31934 http://www.uniprot.org/uniprot/P21580 denotes A20
T14275 31854-31857 http://www.uniprot.org/uniprot/P21580 denotes A20
T14274 30610-30613 http://www.uniprot.org/uniprot/P21580 denotes A20
T14273 30560-30563 http://www.uniprot.org/uniprot/P21580 denotes A20
T14272 30406-30409 http://www.uniprot.org/uniprot/P21580 denotes A20
T14271 30090-30093 http://www.uniprot.org/uniprot/P21580 denotes A20
T14270 29796-29799 http://www.uniprot.org/uniprot/P21580 denotes A20
T14269 29714-29717 http://www.uniprot.org/uniprot/P21580 denotes A20
T14268 29237-29240 http://www.uniprot.org/uniprot/P21580 denotes A20
T14267 29050-29053 http://www.uniprot.org/uniprot/P21580 denotes A20
T14266 28962-28965 http://www.uniprot.org/uniprot/P21580 denotes A20
T14265 28680-28683 http://www.uniprot.org/uniprot/P21580 denotes A20
T14264 28315-28318 http://www.uniprot.org/uniprot/P21580 denotes A20
T14263 28056-28059 http://www.uniprot.org/uniprot/P21580 denotes A20
T14262 27218-27221 http://www.uniprot.org/uniprot/P21580 denotes A20
T14261 25470-25473 http://www.uniprot.org/uniprot/P21580 denotes A20
T11143 23964-23969 http://www.uniprot.org/uniprot/P01584 denotes IL-1β
T11142 23956-23959 http://www.uniprot.org/uniprot/P01375 denotes TNF
T11141 22004-22007 http://www.uniprot.org/uniprot/P10966 denotes CD8
T11140 21808-21811 http://www.uniprot.org/uniprot/P10966 denotes CD8
T11139 21700-21703 http://www.uniprot.org/uniprot/P10966 denotes CD8
T11138 21631-21634 http://www.uniprot.org/uniprot/P10966 denotes CD8
T11137 21502-21505 http://www.uniprot.org/uniprot/P10966 denotes CD8
T11136 22004-22007 http://www.uniprot.org/uniprot/P01732 denotes CD8
T11135 21808-21811 http://www.uniprot.org/uniprot/P01732 denotes CD8
T11134 21700-21703 http://www.uniprot.org/uniprot/P01732 denotes CD8
T11133 21631-21634 http://www.uniprot.org/uniprot/P01732 denotes CD8
T11132 21502-21505 http://www.uniprot.org/uniprot/P01732 denotes CD8
T11131 20427-20431 http://www.uniprot.org/uniprot/P10145 denotes IL-8
T11130 23950-23954 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T11129 20069-20073 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T11128 23683-23688 http://www.uniprot.org/uniprot/P10889 denotes MIP-2
T11127 20680-20685 http://www.uniprot.org/uniprot/P10889 denotes MIP-2
T11126 20457-20462 http://www.uniprot.org/uniprot/P10889 denotes MIP-2
T11125 20040-20045 http://www.uniprot.org/uniprot/P10889 denotes MIP-2
T11124 24474-24477 http://www.uniprot.org/uniprot/P21580 denotes A20
T11123 22549-22552 http://www.uniprot.org/uniprot/P21580 denotes A20
T11122 22242-22245 http://www.uniprot.org/uniprot/P21580 denotes A20
T11121 22099-22102 http://www.uniprot.org/uniprot/P21580 denotes A20
T11120 21555-21558 http://www.uniprot.org/uniprot/P21580 denotes A20
T11119 19803-19806 http://www.uniprot.org/uniprot/P21580 denotes A20
T11118 18793-18796 http://www.uniprot.org/uniprot/P21580 denotes A20
T11117 17717-17720 http://www.uniprot.org/uniprot/P21580 denotes A20
T11116 17624-17627 http://www.uniprot.org/uniprot/P21580 denotes A20
T8355 17606-17610 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T8354 17170-17173 http://www.uniprot.org/uniprot/P01375 denotes TNF
T8353 15806-15809 http://www.uniprot.org/uniprot/P01375 denotes TNF
T8352 17161-17165 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T8351 15618-15622 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T8350 17570-17573 http://www.uniprot.org/uniprot/P21580 denotes A20
T8349 17421-17424 http://www.uniprot.org/uniprot/P21580 denotes A20
T8348 17307-17310 http://www.uniprot.org/uniprot/P21580 denotes A20
T8347 16913-16916 http://www.uniprot.org/uniprot/P21580 denotes A20
T8346 15507-15510 http://www.uniprot.org/uniprot/P21580 denotes A20
T8345 15440-15443 http://www.uniprot.org/uniprot/P21580 denotes A20
T8344 15387-15390 http://www.uniprot.org/uniprot/P21580 denotes A20
T8343 15297-15300 http://www.uniprot.org/uniprot/P21580 denotes A20
T8342 15209-15212 http://www.uniprot.org/uniprot/P21580 denotes A20
T6695 14942-14945 http://www.uniprot.org/uniprot/P01375 denotes TNF
T6694 14759-14762 http://www.uniprot.org/uniprot/P01375 denotes TNF
T6693 14936-14940 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T6692 14750-14754 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T6691 14266-14270 http://www.uniprot.org/uniprot/Q9UHD2 denotes TBK1
T6690 14577-14580 http://www.uniprot.org/uniprot/P21579 denotes p65
T6689 13986-13989 http://www.uniprot.org/uniprot/P21579 denotes p65
T6688 14577-14580 http://www.uniprot.org/uniprot/Q04206 denotes p65
T6687 13986-13989 http://www.uniprot.org/uniprot/Q04206 denotes p65
T6686 13926-13930 http://www.uniprot.org/uniprot/P25963 denotes IκBα
T6685 13391-13395 http://www.uniprot.org/uniprot/O15455 denotes TLR3
T6684 12909-12912 http://www.uniprot.org/uniprot/P06956 denotes Cre
T6683 10587-10597 http://www.uniprot.org/uniprot/P08659 denotes luciferase
T6682 9932-9942 http://www.uniprot.org/uniprot/P08659 denotes luciferase
T6681 10939-10943 http://www.uniprot.org/uniprot/Q92985 denotes IRF7
T6680 10837-10841 http://www.uniprot.org/uniprot/Q92985 denotes IRF7
T6679 10661-10665 http://www.uniprot.org/uniprot/Q92985 denotes IRF7
T6678 10567-10571 http://www.uniprot.org/uniprot/Q92985 denotes IRF7
T6677 10485-10489 http://www.uniprot.org/uniprot/Q92985 denotes IRF7
T6676 10423-10427 http://www.uniprot.org/uniprot/Q92985 denotes IRF7
T6675 10298-10302 http://www.uniprot.org/uniprot/Q92985 denotes IRF7
T6674 10239-10243 http://www.uniprot.org/uniprot/Q92985 denotes IRF7
T6673 10209-10213 http://www.uniprot.org/uniprot/Q92985 denotes IRF7
T6672 9554-9558 http://www.uniprot.org/uniprot/Q92985 denotes IRF7
T6671 15168-15172 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6670 14865-14869 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6669 14778-14782 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6668 14582-14586 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6667 14450-14454 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6666 14142-14146 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6665 13416-13420 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6664 11063-11067 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6663 10889-10893 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6662 10361-10365 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6661 10233-10237 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6660 9917-9921 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6659 9787-9791 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6658 9545-9549 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6657 9480-9484 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T6656 15086-15089 http://www.uniprot.org/uniprot/P21580 denotes A20
T6655 14657-14660 http://www.uniprot.org/uniprot/P21580 denotes A20
T6654 13802-13805 http://www.uniprot.org/uniprot/P21580 denotes A20
T6653 13704-13707 http://www.uniprot.org/uniprot/P21580 denotes A20
T6652 13669-13672 http://www.uniprot.org/uniprot/P21580 denotes A20
T6651 13541-13544 http://www.uniprot.org/uniprot/P21580 denotes A20
T6650 13059-13062 http://www.uniprot.org/uniprot/P21580 denotes A20
T6649 12781-12784 http://www.uniprot.org/uniprot/P21580 denotes A20
T6648 12648-12651 http://www.uniprot.org/uniprot/P21580 denotes A20
T6647 12607-12610 http://www.uniprot.org/uniprot/P21580 denotes A20
T6646 12498-12501 http://www.uniprot.org/uniprot/P21580 denotes A20
T6645 11024-11027 http://www.uniprot.org/uniprot/P21580 denotes A20
T6644 10906-10909 http://www.uniprot.org/uniprot/P21580 denotes A20
T6643 10556-10559 http://www.uniprot.org/uniprot/P21580 denotes A20
T6642 10416-10419 http://www.uniprot.org/uniprot/P21580 denotes A20
T6641 10191-10194 http://www.uniprot.org/uniprot/P21580 denotes A20
T6640 9861-9864 http://www.uniprot.org/uniprot/P21580 denotes A20
T6639 9752-9755 http://www.uniprot.org/uniprot/P21580 denotes A20
T6638 9443-9446 http://www.uniprot.org/uniprot/P21580 denotes A20
T3682 7516-7520 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T3681 9369-9372 http://www.uniprot.org/uniprot/P21580 denotes A20
T3680 8815-8818 http://www.uniprot.org/uniprot/P21580 denotes A20
T3679 8673-8676 http://www.uniprot.org/uniprot/P21580 denotes A20
T3678 8581-8584 http://www.uniprot.org/uniprot/P21580 denotes A20
T3677 8463-8466 http://www.uniprot.org/uniprot/P21580 denotes A20
T3676 8270-8273 http://www.uniprot.org/uniprot/P21580 denotes A20
T3675 8071-8074 http://www.uniprot.org/uniprot/P21580 denotes A20
T3674 7884-7887 http://www.uniprot.org/uniprot/P21580 denotes A20
T3673 7750-7753 http://www.uniprot.org/uniprot/P21580 denotes A20
T3672 7618-7621 http://www.uniprot.org/uniprot/P21580 denotes A20
T3671 7573-7576 http://www.uniprot.org/uniprot/P21580 denotes A20
T3670 7444-7447 http://www.uniprot.org/uniprot/P21580 denotes A20
T3669 7214-7217 http://www.uniprot.org/uniprot/P21580 denotes A20
T3668 7120-7123 http://www.uniprot.org/uniprot/P21580 denotes A20
T3667 7062-7067 http://www.uniprot.org/uniprot/Q9BYM8 denotes RBCK1
T3666 6822-6827 http://www.uniprot.org/uniprot/Q13114 denotes TRAF3
T3665 6377-6382 http://www.uniprot.org/uniprot/Q13114 denotes TRAF3
T3664 6356-6361 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TRAF6
T3663 8491-8495 http://www.uniprot.org/uniprot/O15455 denotes TLR3
T3662 5330-5334 http://www.uniprot.org/uniprot/O15455 denotes TLR3
T3661 4994-4998 http://www.uniprot.org/uniprot/O15455 denotes TLR3
T3660 3867-3871 http://www.uniprot.org/uniprot/O15455 denotes TLR3
T3659 6993-6997 http://www.uniprot.org/uniprot/Q92985 denotes IRF7
T3658 3461-3465 http://www.uniprot.org/uniprot/Q92985 denotes IRF7
T3657 8527-8532 http://www.uniprot.org/uniprot/Q14653 denotes IRF-3
T3656 6984-6988 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T3655 6419-6423 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T3654 3452-3456 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T3653 3446-3450 http://www.uniprot.org/uniprot/P05412 denotes AP-1
T3652 3322-3332 http://www.uniprot.org/uniprot/P01562 denotes α) and IFN
T3651 3315-3321 http://www.uniprot.org/uniprot/P01562 denotes α (IFN
T3650 3265-3269 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T3649 7490-7493 http://www.uniprot.org/uniprot/P01375 denotes TNF
T3648 3260-3263 http://www.uniprot.org/uniprot/P01375 denotes TNF
T541 992-996 http://www.uniprot.org/uniprot/Q14653 denotes IRF3
T540 1526-1529 http://www.uniprot.org/uniprot/P21580 denotes A20
T539 1275-1278 http://www.uniprot.org/uniprot/P21580 denotes A20
T538 866-869 http://www.uniprot.org/uniprot/P21580 denotes A20
T537 811-814 http://www.uniprot.org/uniprot/P21580 denotes A20
T536 740-743 http://www.uniprot.org/uniprot/P21580 denotes A20
T17719 38466-38469 http://www.uniprot.org/uniprot/P21580 denotes A20

UBERON-AE

Id Subject Object Predicate Lexical cue
T20778 19219-19223 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T20777 19020-19024 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T17825 39073-39080 http://purl.obolibrary.org/obo/UBERON_0003126 denotes trachea
T17824 38846-38851 http://purl.obolibrary.org/obo/UBERON_0002048 denotes Lungs
T16542 37305-37309 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T16541 37275-37282 http://purl.obolibrary.org/obo/UBERON_0003126 denotes trachea
T16540 36957-36968 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
T16108 35696-35700 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T16107 35625-35630 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lungs
T15281 34195-34200 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T15280 34004-34008 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T15279 33901-33906 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lungs
T15278 33836-33842 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T15659 35300-35305 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T15658 35176-35181 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T15657 34588-34593 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T11702 31447-31453 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T11701 30443-30450 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
T11700 25616-25626 http://purl.obolibrary.org/obo/UBERON_0000353 denotes parenchyma
T11699 25611-25626 http://purl.obolibrary.org/obo/UBERON_0008946 denotes lung parenchyma
T11698 30719-30723 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T11697 28614-28618 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T11696 26091-26095 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T11695 25611-25615 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T11694 25539-25543 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T8719 22353-22358 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T8718 21743-21753 http://purl.obolibrary.org/obo/UBERON_0000353 denotes parenchyma
T8717 21738-21753 http://purl.obolibrary.org/obo/UBERON_0008946 denotes lung parenchyma
T8716 24060-24065 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lungs
T8715 23872-23877 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lungs
T8714 23398-23402 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T8713 22969-22973 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T8712 21738-21742 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T8711 19878-19882 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T8710 18176-18180 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T8709 17677-17681 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T7697 17017-17022 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lungs
T7696 16853-16857 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T4723 12715-12720 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organ
T910 9017-9021 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T909 7679-7684 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organ
T23 1211-1216 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lungs

GO-BP

Id Subject Object Predicate Lexical cue
T21236 25145-25153 http://purl.obolibrary.org/obo/GO_0048286 denotes alveolar
T21235 25068-25071 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T20796 19543-19551 http://purl.obolibrary.org/obo/GO_0048286 denotes alveolar
T20795 19420-19423 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T20309 16327-16335 http://purl.obolibrary.org/obo/GO_0048286 denotes Alveolar
T20308 15941-15949 http://purl.obolibrary.org/obo/GO_0048286 denotes alveolar
T20307 15913-15928 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T19414 11731-11742 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T19413 11753-11768 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T19412 11711-11726 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T19411 11416-11435 http://purl.obolibrary.org/obo/GO_0050397 denotes Luciferase activity
T19410 11416-11435 http://purl.obolibrary.org/obo/GO_0050248 denotes Luciferase activity
T19409 11416-11435 http://purl.obolibrary.org/obo/GO_0047712 denotes Luciferase activity
T19408 11416-11435 http://purl.obolibrary.org/obo/GO_0047077 denotes Luciferase activity
T19407 11416-11435 http://purl.obolibrary.org/obo/GO_0045289 denotes Luciferase activity
T19406 11130-11144 http://purl.obolibrary.org/obo/GO_0007252 denotes inhibits NF-κB
T19405 11130-11144 http://purl.obolibrary.org/obo/GO_0032088 denotes inhibits NF-κB
T18684 41354-41358 http://purl.obolibrary.org/obo/GO_0004422 denotes HPRT
T18683 40693-40697 http://purl.obolibrary.org/obo/GO_0004422 denotes HPRT
T18682 40486-40495 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T18681 40351-40360 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T19105 41808-41810 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T18288 40109-40112 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T17170 38254-38265 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T17169 37903-37914 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T17168 37689-37700 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T17167 37577-37582 http://purl.obolibrary.org/obo/GO_0019835 denotes lysis
T16558 37362-37370 http://purl.obolibrary.org/obo/GO_0048286 denotes Alveolar
T16557 37249-37257 http://purl.obolibrary.org/obo/GO_0048286 denotes alveolar
T16556 36957-36974 http://purl.obolibrary.org/obo/GO_0071838 denotes bone marrow cells
T16555 36957-36974 http://purl.obolibrary.org/obo/GO_0071839 denotes bone marrow cells
T15290 33398-33413 http://purl.obolibrary.org/obo/GO_0016032 denotes Viral infection
T15672 35248-35261 http://purl.obolibrary.org/obo/GO_0007157 denotes agglutination
T15671 35183-35196 http://purl.obolibrary.org/obo/GO_0007157 denotes agglutination
T15670 34638-34651 http://purl.obolibrary.org/obo/GO_0007157 denotes agglutination
T15669 35248-35261 http://purl.obolibrary.org/obo/GO_0000752 denotes agglutination
T15668 35183-35196 http://purl.obolibrary.org/obo/GO_0000752 denotes agglutination
T15667 34638-34651 http://purl.obolibrary.org/obo/GO_0000752 denotes agglutination
T14999 33130-33133 http://purl.obolibrary.org/obo/GO_0007568 denotes age
T14801 32346-32357 http://purl.obolibrary.org/obo/GO_0065007 denotes regulations
T11904 31520-31524 http://purl.obolibrary.org/obo/GO_0016246 denotes RNAi
T11903 31193-31209 http://purl.obolibrary.org/obo/GO_0016246 denotes RNA interference
T11902 30003-30027 http://purl.obolibrary.org/obo/GO_0004843 denotes deubiquitinating enzymes
T11901 29858-29885 http://purl.obolibrary.org/obo/GO_0001773 denotes activation in myeloid cells
T11900 29858-29885 http://purl.obolibrary.org/obo/GO_0045639 denotes activation in myeloid cells
T11899 29858-29885 http://purl.obolibrary.org/obo/GO_0033034 denotes activation in myeloid cells
T11898 29541-29557 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T11897 29513-29523 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T11896 29634-29638 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T11895 29404-29408 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T11894 29330-29334 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T11893 28975-28993 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T11892 29033-29048 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T11891 28721-28736 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T11890 30479-30488 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T11889 30149-30158 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T11888 29168-29177 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T11887 28975-28984 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T11886 28653-28662 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T11885 30143-30158 http://purl.obolibrary.org/obo/GO_0039529 denotes RIG-I signaling
T11884 28647-28662 http://purl.obolibrary.org/obo/GO_0039529 denotes RIG-I signaling
T11883 27883-27900 http://purl.obolibrary.org/obo/GO_0034097 denotes cytokine response
T11882 27331-27347 http://purl.obolibrary.org/obo/GO_0071605 denotes MCP-1 production
T11881 27331-27347 http://purl.obolibrary.org/obo/GO_0071637 denotes MCP-1 production
T11880 27398-27401 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T11879 27331-27334 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T11878 27169-27172 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T11877 32055-32071 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T11876 27035-27050 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T11875 26383-26391 http://purl.obolibrary.org/obo/GO_0048286 denotes alveolar
T11874 25811-25819 http://purl.obolibrary.org/obo/GO_0048286 denotes alveolar
T11873 25726-25734 http://purl.obolibrary.org/obo/GO_0048286 denotes alveolar
T11872 25680-25688 http://purl.obolibrary.org/obo/GO_0048286 denotes alveolar
T11871 25635-25643 http://purl.obolibrary.org/obo/GO_0048286 denotes alveolar
T11870 31792-31807 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T11869 28572-28587 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T11868 28513-28528 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T11867 25863-25878 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T11866 25516-25531 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T11865 28506-28528 http://purl.obolibrary.org/obo/GO_0045824 denotes innate immune response
T11864 25856-25878 http://purl.obolibrary.org/obo/GO_0045824 denotes innate immune response
T11863 25509-25531 http://purl.obolibrary.org/obo/GO_0045824 denotes innate immune response
T11862 28506-28528 http://purl.obolibrary.org/obo/GO_0045089 denotes innate immune response
T11861 25856-25878 http://purl.obolibrary.org/obo/GO_0045089 denotes innate immune response
T11860 25509-25531 http://purl.obolibrary.org/obo/GO_0045089 denotes innate immune response
T11859 28506-28528 http://purl.obolibrary.org/obo/GO_0002218 denotes innate immune response
T11858 25856-25878 http://purl.obolibrary.org/obo/GO_0002218 denotes innate immune response
T11857 25509-25531 http://purl.obolibrary.org/obo/GO_0002218 denotes innate immune response
T11856 28506-28528 http://purl.obolibrary.org/obo/GO_0045088 denotes innate immune response
T11855 25856-25878 http://purl.obolibrary.org/obo/GO_0045088 denotes innate immune response
T11854 25509-25531 http://purl.obolibrary.org/obo/GO_0045088 denotes innate immune response
T11853 28506-28528 http://purl.obolibrary.org/obo/GO_0002227 denotes innate immune response
T11852 25856-25878 http://purl.obolibrary.org/obo/GO_0002227 denotes innate immune response
T11851 25509-25531 http://purl.obolibrary.org/obo/GO_0002227 denotes innate immune response
T11850 28506-28528 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T11849 25856-25878 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T11848 25509-25531 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T11847 26064-26077 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T11846 25856-25869 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T11845 25509-25522 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T8854 24148-24164 http://purl.obolibrary.org/obo/GO_0071605 denotes MCP-1 production
T8853 24148-24164 http://purl.obolibrary.org/obo/GO_0071637 denotes MCP-1 production
T8852 23683-23699 http://purl.obolibrary.org/obo/GO_2000341 denotes MIP-2 production
T8851 23683-23699 http://purl.obolibrary.org/obo/GO_0072567 denotes MIP-2 production
T8850 23035-23054 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T8849 24538-24560 http://purl.obolibrary.org/obo/GO_0045824 denotes innate immune response
T8848 22678-22700 http://purl.obolibrary.org/obo/GO_0045824 denotes innate immune response
T8847 24538-24560 http://purl.obolibrary.org/obo/GO_0045089 denotes innate immune response
T8846 22678-22700 http://purl.obolibrary.org/obo/GO_0045089 denotes innate immune response
T8845 24538-24560 http://purl.obolibrary.org/obo/GO_0002218 denotes innate immune response
T8844 22678-22700 http://purl.obolibrary.org/obo/GO_0002218 denotes innate immune response
T8843 24538-24560 http://purl.obolibrary.org/obo/GO_0045088 denotes innate immune response
T8842 22678-22700 http://purl.obolibrary.org/obo/GO_0045088 denotes innate immune response
T8841 24538-24560 http://purl.obolibrary.org/obo/GO_0002227 denotes innate immune response
T8840 22678-22700 http://purl.obolibrary.org/obo/GO_0002227 denotes innate immune response
T8839 24538-24560 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T8838 22678-22700 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T8837 22678-22691 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T8836 22273-22295 http://purl.obolibrary.org/obo/GO_0001909 denotes cell mediated immunity
T8835 22273-22295 http://purl.obolibrary.org/obo/GO_0002443 denotes cell mediated immunity
T8834 22273-22295 http://purl.obolibrary.org/obo/GO_0002228 denotes cell mediated immunity
T8833 22273-22295 http://purl.obolibrary.org/obo/GO_0019724 denotes cell mediated immunity
T8832 22273-22295 http://purl.obolibrary.org/obo/GO_0002456 denotes cell mediated immunity
T8831 22273-22295 http://purl.obolibrary.org/obo/GO_0002449 denotes cell mediated immunity
T8830 24545-24560 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T8829 22685-22700 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T8828 22201-22216 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T8827 22193-22216 http://purl.obolibrary.org/obo/GO_0002921 denotes humoral immune response
T8826 22193-22216 http://purl.obolibrary.org/obo/GO_0002920 denotes humoral immune response
T8825 22193-22216 http://purl.obolibrary.org/obo/GO_0006959 denotes humoral immune response
T8824 22193-22216 http://purl.obolibrary.org/obo/GO_0002922 denotes humoral immune response
T8823 22779-22787 http://purl.obolibrary.org/obo/GO_0048286 denotes alveolar
T8822 21221-21229 http://purl.obolibrary.org/obo/GO_0048286 denotes alveolar
T8821 20625-20633 http://purl.obolibrary.org/obo/GO_0048286 denotes alveolar
T8820 24148-24151 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T8819 21168-21171 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T8818 20507-20510 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T8817 20323-20326 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T8816 19855-19870 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T8815 18836-18853 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T8814 18836-18853 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T7784 17224-17227 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T7783 17118-17127 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T7782 17507-17515 http://purl.obolibrary.org/obo/GO_0048286 denotes alveolar
T7781 16966-16974 http://purl.obolibrary.org/obo/GO_0048286 denotes alveolar
T7780 16741-16749 http://purl.obolibrary.org/obo/GO_0048286 denotes alveolar
T7779 15532-15547 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T7778 15357-15373 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T7777 15350-15373 http://purl.obolibrary.org/obo/GO_0045824 denotes innate immune responses
T7776 15350-15373 http://purl.obolibrary.org/obo/GO_0045089 denotes innate immune responses
T7775 15350-15373 http://purl.obolibrary.org/obo/GO_0002218 denotes innate immune responses
T7774 15350-15373 http://purl.obolibrary.org/obo/GO_0045088 denotes innate immune responses
T7773 15350-15373 http://purl.obolibrary.org/obo/GO_0002227 denotes innate immune responses
T7772 15350-15373 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune responses
T7771 15350-15363 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T7770 17488-17503 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T7769 16947-16962 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T7768 15246-15261 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T4949 14841-14860 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T4948 9524-9543 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T4947 12519-12528 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T4946 9502-9511 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T4945 9496-9511 http://purl.obolibrary.org/obo/GO_0039529 denotes RIG-I signaling
T4962 15130-15140 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T4961 14266-14270 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T4960 14249-14252 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T4959 13911-13922 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T4958 14455-14470 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T4957 14177-14192 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T4956 13881-13896 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T4955 13435-13454 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T4954 13421-13454 http://purl.obolibrary.org/obo/GO_0001819 denotes activation or cytokine production
T4953 13421-13454 http://purl.obolibrary.org/obo/GO_1903557 denotes activation or cytokine production
T4952 12721-12733 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T4951 10789-10804 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T4950 9559-9572 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T1164 9326-9348 http://purl.obolibrary.org/obo/GO_0045824 denotes innate immune response
T1163 9326-9348 http://purl.obolibrary.org/obo/GO_0045089 denotes innate immune response
T1162 9326-9348 http://purl.obolibrary.org/obo/GO_0002218 denotes innate immune response
T1161 9326-9348 http://purl.obolibrary.org/obo/GO_0045088 denotes innate immune response
T1160 9326-9348 http://purl.obolibrary.org/obo/GO_0002227 denotes innate immune response
T1159 9234-9242 http://purl.obolibrary.org/obo/GO_0048286 denotes alveolar
T1158 9326-9348 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T1157 9191-9204 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T1156 9144-9164 http://purl.obolibrary.org/obo/GO_0032602 denotes chemokine production
T1155 8604-8619 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T1154 7531-7536 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1R
T1153 8281-8291 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T1152 8217-8227 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T1151 7401-7411 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T1150 7288-7303 http://purl.obolibrary.org/obo/GO_0016874 denotes ligase activity
T1149 7278-7303 http://purl.obolibrary.org/obo/GO_0034450 denotes ubiquitin ligase activity
T1148 7278-7303 http://purl.obolibrary.org/obo/GO_1904667 denotes ubiquitin ligase activity
T1147 7278-7303 http://purl.obolibrary.org/obo/GO_1904668 denotes ubiquitin ligase activity
T1146 7278-7303 http://purl.obolibrary.org/obo/GO_1990757 denotes ubiquitin ligase activity
T1145 7278-7303 http://purl.obolibrary.org/obo/GO_1904666 denotes ubiquitin ligase activity
T1144 7278-7303 http://purl.obolibrary.org/obo/GO_0050372 denotes ubiquitin ligase activity
T1143 7275-7277 http://purl.obolibrary.org/obo/GO_0061667 denotes E3
T1142 7275-7277 http://purl.obolibrary.org/obo/GO_0061666 denotes E3
T1141 7275-7277 http://purl.obolibrary.org/obo/GO_0061665 denotes E3
T1140 7275-7277 http://purl.obolibrary.org/obo/GO_0061664 denotes E3
T1139 7275-7277 http://purl.obolibrary.org/obo/GO_0061663 denotes E3
T1138 7275-7277 http://purl.obolibrary.org/obo/GO_0061662 denotes E3
T1137 7275-7277 http://purl.obolibrary.org/obo/GO_0061661 denotes E3
T1136 7275-7277 http://purl.obolibrary.org/obo/GO_0061660 denotes E3
T1135 7275-7277 http://purl.obolibrary.org/obo/GO_0061659 denotes E3
T1134 7278-7303 http://purl.obolibrary.org/obo/GO_0061630 denotes ubiquitin ligase activity
T1133 7275-7277 http://purl.obolibrary.org/obo/GO_0061630 denotes E3
T1132 7275-7277 http://purl.obolibrary.org/obo/GO_0019787 denotes E3
T1131 7278-7303 http://purl.obolibrary.org/obo/GO_0004842 denotes ubiquitin ligase activity
T1130 7275-7277 http://purl.obolibrary.org/obo/GO_0004842 denotes E3
T1129 6852-6863 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T1128 6956-6969 http://purl.obolibrary.org/obo/GO_0000209 denotes polyubiquitin
T1127 6652-6665 http://purl.obolibrary.org/obo/GO_0000209 denotes polyubiquitin
T1126 6478-6502 http://purl.obolibrary.org/obo/GO_0004843 denotes deubiquitinating enzymes
T1125 7106-7118 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T1124 6144-6156 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T1123 6128-6156 http://purl.obolibrary.org/obo/GO_0090520 denotes mediated signal transduction
T1122 6128-6156 http://purl.obolibrary.org/obo/GO_0038008 denotes mediated signal transduction
T1121 6128-6156 http://purl.obolibrary.org/obo/GO_0007266 denotes mediated signal transduction
T1120 6128-6156 http://purl.obolibrary.org/obo/GO_0048015 denotes mediated signal transduction
T1119 6128-6156 http://purl.obolibrary.org/obo/GO_0019933 denotes mediated signal transduction
T1118 6128-6156 http://purl.obolibrary.org/obo/GO_0007265 denotes mediated signal transduction
T1117 6128-6156 http://purl.obolibrary.org/obo/GO_0007263 denotes mediated signal transduction
T1116 6128-6156 http://purl.obolibrary.org/obo/GO_0016601 denotes mediated signal transduction
T1115 5554-5566 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T1114 8146-8158 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T1113 7834-7846 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T1112 7685-7697 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T1111 4552-4573 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T1110 4078-4097 http://purl.obolibrary.org/obo/GO_0051607 denotes antiviral responses
T1109 3576-3595 http://purl.obolibrary.org/obo/GO_0019083 denotes viral transcription
T1108 4975-4992 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T1107 3540-3557 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T1106 4975-4992 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T1105 3540-3557 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T1104 3535-3557 http://purl.obolibrary.org/obo/GO_0039693 denotes DNA, viral replication
T1103 3527-3557 http://purl.obolibrary.org/obo/GO_0039688 denotes RNA and DNA, viral replication
T1102 6998-7011 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T1101 3582-3595 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T1100 3409-3422 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T1099 7099-7118 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T1098 6137-6156 http://purl.obolibrary.org/obo/GO_0007165 denotes signal transduction
T1097 3369-3387 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T1096 8896-8905 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T1095 8504-8513 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T1094 7431-7440 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T1093 6900-6909 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T1092 6686-6695 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T1091 6606-6615 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T1090 5228-5237 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T1089 3369-3378 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T1088 9333-9348 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T1087 5178-5193 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T1086 3020-3035 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T59 1167-1175 http://purl.obolibrary.org/obo/GO_0048286 denotes alveolar
T58 601-617 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T57 158-173 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T44 151-164 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T45 151-173 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T46 594-617 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune responses
T47 151-173 http://purl.obolibrary.org/obo/GO_0002227 denotes innate immune response
T48 594-617 http://purl.obolibrary.org/obo/GO_0002227 denotes innate immune responses
T49 151-173 http://purl.obolibrary.org/obo/GO_0045088 denotes innate immune response
T50 594-617 http://purl.obolibrary.org/obo/GO_0045088 denotes innate immune responses
T51 151-173 http://purl.obolibrary.org/obo/GO_0002218 denotes innate immune response
T52 594-617 http://purl.obolibrary.org/obo/GO_0002218 denotes innate immune responses
T53 151-173 http://purl.obolibrary.org/obo/GO_0045089 denotes innate immune response
T54 594-617 http://purl.obolibrary.org/obo/GO_0045089 denotes innate immune responses
T55 151-173 http://purl.obolibrary.org/obo/GO_0045824 denotes innate immune response
T56 594-617 http://purl.obolibrary.org/obo/GO_0045824 denotes innate immune responses

GO-MF

Id Subject Object Predicate Lexical cue
T21239 25075-25079 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T21238 25072-25077 http://purl.obolibrary.org/obo/GO_0005149 denotes 1, IL
T20798 19424-19429 http://purl.obolibrary.org/obo/GO_0005149 denotes 1, IL
T20797 19420-19423 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T19422 12310-12314 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T19421 12215-12219 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T19420 11877-11885 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T19419 11416-11435 http://purl.obolibrary.org/obo/GO_0050397 denotes Luciferase activity
T19418 11416-11435 http://purl.obolibrary.org/obo/GO_0050248 denotes Luciferase activity
T19417 11416-11435 http://purl.obolibrary.org/obo/GO_0047712 denotes Luciferase activity
T19416 11416-11435 http://purl.obolibrary.org/obo/GO_0047077 denotes Luciferase activity
T19415 11416-11435 http://purl.obolibrary.org/obo/GO_0045289 denotes Luciferase activity
T17173 38254-38265 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T17172 37903-37914 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T17171 37689-37700 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T15675 34810-34817 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T15674 34810-34826 http://purl.obolibrary.org/obo/GO_0005515 denotes binding proteins
T15673 34798-34817 http://purl.obolibrary.org/obo/GO_0033691 denotes sialic acid binding
T7788 17224-17227 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T7787 17161-17165 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T7786 15618-15622 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T1200 7531-7536 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1R
T1199 7288-7303 http://purl.obolibrary.org/obo/GO_0016874 denotes ligase activity
T1198 7278-7303 http://purl.obolibrary.org/obo/GO_0034450 denotes ubiquitin ligase activity
T1197 7278-7303 http://purl.obolibrary.org/obo/GO_1990757 denotes ubiquitin ligase activity
T1196 7278-7303 http://purl.obolibrary.org/obo/GO_0050372 denotes ubiquitin ligase activity
T1195 7275-7277 http://purl.obolibrary.org/obo/GO_0061667 denotes E3
T1194 7275-7277 http://purl.obolibrary.org/obo/GO_0061666 denotes E3
T1193 7275-7277 http://purl.obolibrary.org/obo/GO_0061665 denotes E3
T1192 7275-7277 http://purl.obolibrary.org/obo/GO_0061664 denotes E3
T1191 7275-7277 http://purl.obolibrary.org/obo/GO_0061663 denotes E3
T1190 7275-7277 http://purl.obolibrary.org/obo/GO_0061662 denotes E3
T1189 7275-7277 http://purl.obolibrary.org/obo/GO_0061661 denotes E3
T1188 7275-7277 http://purl.obolibrary.org/obo/GO_0061660 denotes E3
T1187 7275-7277 http://purl.obolibrary.org/obo/GO_0061659 denotes E3
T1186 7278-7303 http://purl.obolibrary.org/obo/GO_0061630 denotes ubiquitin ligase activity
T1185 7275-7277 http://purl.obolibrary.org/obo/GO_0061630 denotes E3
T1184 7275-7277 http://purl.obolibrary.org/obo/GO_0019787 denotes E3
T1183 7278-7303 http://purl.obolibrary.org/obo/GO_0004842 denotes ubiquitin ligase activity
T1182 7275-7277 http://purl.obolibrary.org/obo/GO_0004842 denotes E3
T11924 30003-30027 http://purl.obolibrary.org/obo/GO_0004843 denotes deubiquitinating enzymes
T11923 29634-29638 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T11922 29404-29408 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T11921 29330-29334 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T11920 29271-29287 http://purl.obolibrary.org/obo/GO_0005515 denotes binding proteins
T11919 29271-29278 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T11918 29261-29287 http://purl.obolibrary.org/obo/GO_0032182 denotes ubiquitin-binding proteins
T11917 29261-29287 http://purl.obolibrary.org/obo/GO_0031625 denotes ubiquitin-binding proteins
T11916 29261-29278 http://purl.obolibrary.org/obo/GO_0043130 denotes ubiquitin-binding
T11915 29261-29270 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T11914 27398-27401 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T11913 27331-27334 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T11912 27169-27172 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T11911 28774-28778 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T11910 26736-26740 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T11909 26282-26290 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T1181 6478-6502 http://purl.obolibrary.org/obo/GO_0004843 denotes deubiquitinating enzymes
T1180 7278-7287 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T1179 7130-7139 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T1178 6741-6750 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T1177 6330-6339 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T1176 6176-6185 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T1175 6047-6056 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T1174 5724-5731 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T1173 5717-5723 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T1172 5659-5665 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T1171 3274-3288 http://purl.obolibrary.org/obo/GO_0005151 denotes IL-1) and type
T1170 3274-3288 http://purl.obolibrary.org/obo/GO_0005150 denotes IL-1) and type
T1169 3274-3278 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T1168 3265-3269 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T1167 3071-3100 http://purl.obolibrary.org/obo/GO_0038187 denotes pattern recognition receptors
T60 785-794 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T20799 19427-19431 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T20312 16509-16513 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T20311 16409-16413 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T20310 16122-16126 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T18688 40759-40763 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T18687 40755-40761 http://purl.obolibrary.org/obo/GO_0005135 denotes 3′; IL
T18686 41354-41358 http://purl.obolibrary.org/obo/GO_0004422 denotes HPRT
T18685 40693-40697 http://purl.obolibrary.org/obo/GO_0004422 denotes HPRT
T17848 39194-39204 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T16559 37216-37226 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T4967 14936-14940 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T4966 14750-14754 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T4965 14393-14401 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T4964 14266-14270 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T4963 14249-14252 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T21237 25068-25071 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T19106 41808-41810 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T18292 40135-40139 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T18291 40109-40112 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T18290 40069-40079 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T18289 39870-39880 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T8862 22330-22338 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T8861 20427-20431 http://purl.obolibrary.org/obo/GO_0005153 denotes IL-8
T8860 24148-24151 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T8859 21168-21171 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T8858 20507-20510 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T8857 20323-20326 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T8856 23950-23954 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T8855 20069-20073 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6

GO-CC

Id Subject Object Predicate Lexical cue
T21240 24678-24683 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T20800 18993-18998 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T20315 16467-16471 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T20314 16207-16211 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T20313 16101-16106 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19426 11877-11885 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T19425 11877-11885 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T19424 12263-12268 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19423 11211-11216 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18296 40069-40079 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T18295 39870-39880 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T18294 40069-40079 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T18293 39870-39880 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T17853 39721-39726 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17852 39457-39460 http://purl.obolibrary.org/obo/GO_0005680 denotes APC
T17851 39291-39294 http://purl.obolibrary.org/obo/GO_0005680 denotes APC
T17850 39194-39204 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T17849 39194-39204 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T17176 38016-38021 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17175 37775-37780 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17174 37539-37544 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16564 37216-37226 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T16563 37216-37226 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T16562 36969-36974 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16561 36239-36244 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16560 36113-36118 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16137 36065-36070 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16136 35883-35888 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16135 35489-35494 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16134 35439-35444 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16133 35383-35396 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T15294 34201-34206 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15293 34044-34049 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15292 33522-33527 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11938 26282-26290 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T11937 26282-26290 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T11936 30735-30740 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11935 30432-30437 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11934 29880-29885 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11933 27941-27946 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11932 27641-27646 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11931 27299-27304 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11930 27233-27238 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11929 27130-27135 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11928 26272-26277 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11927 26078-26083 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11926 25920-25925 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11925 25496-25501 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8881 24500-24519 http://purl.obolibrary.org/obo/GO_0009986 denotes cells is associated
T8880 22330-22338 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T8879 22330-22338 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T8878 24500-24505 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8877 23091-23096 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8876 22575-22580 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8875 22257-22262 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8874 22114-22119 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8873 22011-22016 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8872 21815-21820 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8871 21707-21712 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8870 21638-21643 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8869 21581-21586 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8868 21509-21514 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8867 21436-21441 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8866 19829-19834 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8865 18808-18813 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8864 17743-17748 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8863 17650-17655 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7795 16716-16720 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T7794 17342-17347 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7793 17293-17298 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7792 17006-17011 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7791 16840-16845 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7790 15773-15778 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7789 15677-15682 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4976 14393-14401 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T4975 14393-14401 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T4974 14350-14357 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T4973 14698-14703 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4972 14123-14128 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4971 13816-13821 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4970 13169-13174 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4969 13004-13009 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4968 9891-9896 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T1226 6832-6842 http://purl.obolibrary.org/obo/GO_0000502 denotes proteasome
T1225 5955-5968 http://purl.obolibrary.org/obo/GO_0044214 denotes transmembrane
T1224 5955-5968 http://purl.obolibrary.org/obo/GO_0016021 denotes transmembrane
T1223 5927-5935 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T1222 5913-5935 http://purl.obolibrary.org/obo/GO_0031966 denotes mitochondrial membrane
T1221 5907-5935 http://purl.obolibrary.org/obo/GO_0031315 denotes outer mitochondrial membrane
T1220 5907-5935 http://purl.obolibrary.org/obo/GO_0031307 denotes outer mitochondrial membrane
T1219 5907-5935 http://purl.obolibrary.org/obo/GO_0031306 denotes outer mitochondrial membrane
T1218 5907-5935 http://purl.obolibrary.org/obo/GO_0005741 denotes outer mitochondrial membrane
T1217 3887-3900 http://purl.obolibrary.org/obo/GO_0005622 denotes Intracellular
T1216 3632-3645 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T1215 9393-9398 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T1214 9205-9210 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T1213 8756-8761 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T1212 8659-8663 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1211 8435-8439 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1210 7766-7770 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1209 4878-4882 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1208 4202-4206 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1207 2944-2948 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T1206 4873-4882 http://purl.obolibrary.org/obo/GO_0043657 denotes host cell
T1205 2939-2948 http://purl.obolibrary.org/obo/GO_0043657 denotes host cell
T1204 4873-4877 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T1203 4547-4551 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T1202 3223-3227 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T1201 2939-2943 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T61 419-432 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T62 726-730 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T63 1261-1265 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T64 1398-1402 http://purl.obolibrary.org/obo/GO_0018995 denotes host

sentences

Id Subject Object Predicate Lexical cue
T24 0-86 Sentence denotes A20 (Tnfaip3) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection
T21224 25311-25395 Sentence denotes Data are representative of 2 independent experiments. *p<0.05; **p<0.01, ***p<0.001.
T21223 25252-25310 Sentence denotes Numbers are averages +/− SEM of at least 5 mice per group.
T21222 25125-25251 Sentence denotes Absolute numbers of alveolar macrophages, neutrophils and monocytes in BAL were analyzed by flow cytometry at 6 days p.i. (D).
T21221 24931-25124 Sentence denotes BAL fluid was collected from wild type (A20myel-WT) and A20myel-KO mice 6 days following infection with a lethal dose IAV and KC, MIP-2, MCP-1, IL-6 and IFNα protein levels were determined (C).
T21220 24723-24930 Sentence denotes A20myel-WT (n = 11) and A20myel-KO (n = 11) mice were intranasally infected with a lethal dose of IAV and survival (p<0.001) (A) and weight loss +/− SEM (B) was monitored for respectively 21 and 15 days p.i.
T21219 24652-24722 Sentence denotes A20 deficiency in myeloid cells protects against lethal IAV infection.
T20786 19660-19789 Sentence denotes Numbers are averages +/− SEM of at least 5 mice per group and are representative of 2 independent experiments. *p<0.05; **p<0.01.
T20785 19514-19659 Sentence denotes Absolute numbers of resident alveolar macrophages, neutrophils and monocytes in BAL were analyzed by flow cytometry at 4, 7 and 10 days p.i. (D).
T20784 19340-19513 Sentence denotes BAL was isolated from IAV infected mice at 4, 7 and 10 days p.i. and KC, MIP-2, MCP-1, IL-6 and IFNα protein levels were analyzed by ELISA and multiplexing technologies (C).
T20783 19320-19339 Sentence denotes ND, not detectable.
T20782 19272-19319 Sentence denotes The dashed line represents the detection limit.
T20781 19158-19271 Sentence denotes At day 4, 7 and 10 post infection (p.i.) viral titers in the lung were measured and expressed as mean TCID50 (B).
T20780 19036-19157 Sentence denotes A20myel-WT and A20myel-KO mice were infected intranasally with a sublethal dose of IAV and weight loss was monitored (A).
T20779 18967-19035 Sentence denotes A20 deficiency in myeloid cells protects against IAV lung infection.
T20286 16641-16710 Sentence denotes Results are representative for 2 independent experiments. ***p<0,001.
T20285 16582-16640 Sentence denotes Error bars represent mean values (+/− SEM) of 2–3 samples.
T20284 16467-16581 Sentence denotes Cell culture supernatant was analyzed for IL-6 and IFNβ protein levels by ELISA and multiplexing technologies (D).
T20283 16409-16466 Sentence denotes IL-6 and IFNβ mRNA expression was determined by qPCR (C).
T20282 16183-16408 Sentence denotes 18 hours post infection cell culture supernatant was analyzed for TNF and IFNβ protein levels by ELISA and multiplexing technologies (B). (C–D) Alveolar macrophages were mock treated or infected with IAV (moi 1) for 18 hours.
T20281 16054-16182 Sentence denotes At different hours post infection (hours p.i.) cells were lysed and IL-6, IFNβ and A20 mRNA expression was analyzed by qPCR (A).
T20280 15963-16053 Sentence denotes (A–B) BMDM isolated from A20myel-WT and A20myel-KO animals were infected with IAV (moi 1).
T20279 15876-15962 Sentence denotes A20 negatively regulates IAV-induced gene expression in BMDM and alveolar macrophages.
T19355 12398-12451 Sentence denotes Data are representative of 2 independent experiments.
T19354 12215-12397 Sentence denotes IL-6, TNF and IFNβ levels in the supernatant of cells used in (B) were determined by bioassay (IL-6) and ELISA (TNF and IFNβ) as described in the ‘materials and methods’ section (D).
T19353 12065-12214 Sentence denotes Quantification of band density for nuclear p65 and IRF3 is shown in bar graphs (expressed as relative density compared to the first lane;  = time 0).
T19352 11947-12064 Sentence denotes Nuclear translocation of NF-κB (p65) and IRF3 was analyzed by immunoblotting of cytoplasmic or nuclear fractions (C).
T19351 11815-11946 Sentence denotes The band that is non-specifically recognized by the anti-IκBα antibody (indicated by an asterisk) can be used as a loading control.
T19350 11484-11814 Sentence denotes Numbers are averages +/− SD of 3 samples per set-up. (B–D) A20myel-KO and wild type (A20myel-WT) BMDM were transfected with LMW poly(I:C) and analyzed at different time points (minutes) after the start of transfection for IκBα phosphorylation and degradation, and IRF3 phosphorylation by immunoblotting of total cell extracts (B).
T19349 11416-11483 Sentence denotes Luciferase activity in cell extracts was analyzed in a luminometer.
T19348 11199-11415 Sentence denotes (A) HEK293T cells were transfected with NF-κB (left), IRF3 (middle) or IRF7 dependent luciferase reporter (right) plasmids, together with plasmids expressing RIG-I (2CARD), IRF7 (right) and increasing amounts of A20.
T19347 11126-11198 Sentence denotes A20 inhibits NF-κB and IRF3 activation in response to RIG-I stimulation.
T18668 41320-41366 Sentence denotes Results are expressed relative to HPRT values.
T18667 41251-41319 Sentence denotes Quantification was performed using the comparative CT method (ΔΔCT).
T18666 41176-41250 Sentence denotes Primers were designed with PerlPrimer (http://perlprimer.sourceforge.net).
T18665 41113-41175 Sentence denotes 5′-TGATGAGCTACTACTGGTCAGC-3′ and 5′-GATCTCTTAGCACAAGGATGGC-3′.
T18664 41044-41112 Sentence denotes 5′-GAGCCTCTAACCAGTTCCAG-3′ and 5′-TGAGTGTGGCTATGACTTCG-3′ and IFNα4:
T18663 40972-41043 Sentence denotes 5′-TTAAAAACCTGGATCGGAACCAA-3′ and 5′-GCATTAGCTTCAGATTTACGGGT-3′; CXCL1:
T18662 40905-40971 Sentence denotes 5′-AAACCAATGGTGATGGAAACTG-3′ and 5′-GTTGTCCCATTCGTCATTCC-3′; CCL2:
T18661 40837-40904 Sentence denotes 5′-TCAGAATGAGTGGTGGTTGC-3′ and 5′-GACCTTTCAAATGCAGTAGATTCA-3′; A20:
T18660 40765-40836 Sentence denotes 5′-GAGGATACCACTCCCAACAGACC-3′ and 5′-AAGTGCATCATCGTTGTTCATACA-3′; IFNβ:
T18659 40699-40764 Sentence denotes 5′-AGTGTTGGATACAGGCCAGAC-3′ and 5′CGTGATTCAAATCCCTGAAGT-3′; IL-6:
T18658 40370-40698 Sentence denotes Total RNA was extracted using Aurum Total RNA mini kit (BioRad) and reverse transcribed into cDNA with iScript cDNA synthesis kit (BioRad) according to the manufacturer's instructions. qPCR was performed by using SYBR Green I master mix I (Roche) in the Lightcycler 480 detection system (Roche) with the following primers: HPRT:
T18657 40331-40369 Sentence denotes RNA isolation, cDNA synthesis and qPCR
T19104 41627-41812 Sentence denotes Statistical significance of differences between survival rates was analyzed by comparing Kaplan-Meier curves using the log-rank test (GraphPad Prism version 5, GraphPad, San Diego, CA).
T19103 41494-41626 Sentence denotes The differences for in vivo experiments (at least 5 mice per group) were calculated using the Mann-Whitney U-test for unpaired data.
T19102 41420-41493 Sentence denotes Statistical significance between groups was assessed using two-way ANOVA.
T19101 41379-41419 Sentence denotes Results are expressed as the mean ± SEM.
T19100 41368-41378 Sentence denotes Statistics
T18271 40247-40329 Sentence denotes Milliplex technology (Millipore) was used for the detection of MIP-2 in BAL fluid.
T18270 40096-40246 Sentence denotes Detection of MCP-1, KC, TNF, IL-1β and IL-6 in BAL fluid was performed using Bioplex (BioRad) technology according to the manufacturer's instructions.
T18269 39976-40095 Sentence denotes For IFNγ ELISA, 96-well plates were coated with IFNγ coating (XMG1.2) and detection (R4-6A2) antibodies (eBiosciences).
T18268 39882-39975 Sentence denotes IFNα and IFNβ protein levels were determined with an ELISA kit (PBL Biomedical Laboratories).
T18267 39753-39881 Sentence denotes For TNF ELISA, 96-well plates were coated with TNF coating (TN3-19, eBioscience) and detection (R4-6A2, eBioscience) antibodies.
T18266 39729-39752 Sentence denotes Cytokine quantification
T17831 39657-39727 Sentence denotes Propidium iodide was used to discriminate between live and dead cells.
T17830 39159-39656 Sentence denotes Cells were stained with monoclonal antibodies directed against MHC-II (I-A/I-E) FITC (M5/114.15.2), CD11c PerCP-Cy5.5 (N418), F4/80 APC (BM8), CD62L PE (MEL-14), Granzyme B FITC (NGZB) from eBiosciences and CD3 Molecular Complex Horizon v450 (17A2), Ly6C Horizon v450 (AL-21), Ly6G PE (1A8), CD11b APC-Cy7 (M1/70), CD8α PerCP (53-6.7), IFNγ Alexa 647 (XMG1.2) and CD16/32 (2.4G2) from BD Pharmingen. Samples were acquired on a LSRII Cytometer and analyzed using FACSDiva software (BD Biosciences).
T17829 39045-39158 Sentence denotes For the preparation of BAL, trachea were canulated and airway lumen was flushed 4 times with HBSS with 1 mM EDTA.
T17828 38971-39044 Sentence denotes Subsequently, samples were filtered through a 70 µm and 40 µm nylon mesh.
T17827 38846-38970 Sentence denotes Lungs were dissected and incubated with collagenase type IV (1 mg/ml; Sigma) and DNAse (100 U/ml; Roche) at 37°C for 30 min.
T17826 38831-38845 Sentence denotes Flow cytometry
T17166 38758-38829 Sentence denotes All intensities were calculated relative to the first lane ( = time 0).
T17165 38639-38757 Sentence denotes The density of the bands was quantified (fold induction) with the ImageJ (http://rsbweb.nih.gov/ij) Gel analyzer tool.
T17164 38430-38638 Sentence denotes Immunoblots were revealed with anti-A20, anti-IκBα, anti-p65, and anti-histon H1 (Santa Cruz), anti-IRF3 (Invitrogen), anti-phospho-IRF3 and anti-phospho-IκBα (Cell Signaling) and anti-actin (MP Biomedicals).
T17163 38059-38429 Sentence denotes The nuclear fraction containing pellet was lyzed in B2 (20 mM Hepes pH 7.5, 1% NP-40, 400 mM NaCl, 10 mM KCl, 1 mM MgCl2, 20% glycerol, 0.5 mM EDTA and 0.1 mM EGTA supplemented with protease and phosphatase inhibitors) for 15 min at 4°C. The lysates were subsequently separated by SDS-PAGE and analyzed by western blotting and ECL detection (Perkin Elmer Life Sciences).
T17162 37713-38058 Sentence denotes Nuclear and cytoplasmic lysates were prepared by resuspending cells in B1 (10 mM Hepes pH 7.5, 10 mM KCl, 1 mM MgCl2, 5% glycerol, 0.5 mM EDTA and 0.1 mM EGTA supplemented with protease and phosphatase inhibitors) for 15 min at 4°C. Next, NP-40 detergent was added to a final concentration of 0.65% and cells were centrifuged at 500 g for 5 min.
T17161 37520-37712 Sentence denotes For total lysates, cells were lysed at 4°C for 15 min in lysis buffer (200 mM NaCl, 1% NP-40, 10 mM Tris-HCl pH 7.5, 5 mM EDTA, 2 mM DTT) supplemented with protease and phosphatase inhibitors.
T17160 37503-37519 Sentence denotes Western blotting
T16550 37362-37501 Sentence denotes Alveolar macrophages were cultured in RPMI 1640 (Gibco) supplemented with 1% FCS, 2 mM L-glutamine, 0.4 mM sodium pyruvate and antibiotics.
T16549 37228-37361 Sentence denotes For the isolation of alveolar macrophages, the trachea was canulated and the lung was flushed 4 times with HBSS containing 1 mM EDTA.
T16548 37130-37227 Sentence denotes BMDM were of ≥95% purity as measured by flow cytometry using F4/80 and CD11b specific antibodies.
T16547 36929-37129 Sentence denotes For the generation of BMDM, bone marrow cells were cultured 7 days in RPMI 1640 (Gibco) supplemented with 10% FCS, 2 mM L-glutamine, 0.4 mM sodium pyruvate, antibiotics and 40 ng/ml recombinant M-CSF.
T16546 36794-36928 Sentence denotes Details of plasmids are presented along with detailed sequence maps at the BCCM-LMBP plasmid databank http://bccm.belspo.be/index.php.
T16545 36231-36793 Sentence denotes HEK293T cells were transfected using the calcium phosphate precipitate transfection method with specific expression vectors (pCAGGS-E-hA20 (LMBP 3778), pCAGGS-E-RIG-I-CARD (LMBP 6517), pEF-HA-IRF-7 (kindly provided by T. Taniguchi, Graduate School of Medicine and Faculty of Medicine, University of Tokyo)), NF-κB, IRF3, IRF7 reporter plasmids (respectively pConLuc (LMBP3248), pISRE-luc (LMBP4011), pGL3-IFNα4-luc (kindly provided by J. Hiscott, McGill University, Montreal, Quebec, Canada), and pACTbetagal (LMBP4341) for transfection efficiency normalization.
T16544 36096-36230 Sentence denotes HEK293T and MDCK cells were grown in DMEM (Gibco) supplemented with 10% FCS, 2 mM L-glutamine, 0.4 mM sodium pyruvate and antibiotics.
T16543 36073-36095 Sentence denotes Cells and transfection
T16113 35963-36071 Sentence denotes Live/Dead fixable aqua dead cell stain kit (Molecular Probes) was used to discriminate live from dead cells.
T16112 35866-35962 Sentence denotes Activated CD8+ T cells were analyzed by flow cytometry based on CD62lo CD3+ and CD8+ expression.
T16111 35606-35865 Sentence denotes 6 h later, BAL and lungs were isolated and single cell suspensions were prepared from the lung in the presence of 3 µg/ml Brefeldin A. Cells were stained, fixed and permeabilized (Cytofix/Cytoperm, BD Biosciences) according to the manufacturer's instructions.
T16110 35445-35605 Sentence denotes Granzyme B (GrB) and IFNγ expressing CD8+ T cells were determined by treating the mice intranasally with 50 µg Brefeldin A (Sigma) as previously described [86].
T16109 35375-35444 Sentence denotes In vivo intracellular GrB and IFNγ staining of activated CD8+ T cells
T15289 34282-34365 Sentence denotes TCID50 titers were then calculated according to the method of Reed and Muench [85].
T15288 34164-34281 Sentence denotes For read-out, 0.5% chicken red blood cells (RBC) were added and end-point dilution of hemagglutination was monitored.
T15287 33973-34163 Sentence denotes Eight-fold serial dilutions of lung homogenates were incubated on MDCK cells for 5 days in DMEM supplemented with trypsin (1 µg/ml), 2 mM L-glutamine, 0.4 mM sodium pyruvate and antibiotics.
T15286 33792-33972 Sentence denotes To determine pulmonary viral titers, median tissue culture infectious dose (TCID50) was measured as follows: lungs were homogenized with a Polytron homogenizer (Kinematica) in PBS.
T15285 33703-33791 Sentence denotes For lethal and sublethal infection, mice received respectively 2-LD50 or 0.05-LD50 X-47.
T15284 33529-33702 Sentence denotes For viral inoculation, mice were anesthetized by i.p. injection with ketamine (12 mg/kg) and xylazine (60 mg/kg) and 50 µl X-47 diluted in PBS was administered intranasally.
T15283 33448-33528 Sentence denotes Mouse adapted IAV X-47 (H3N2; PR8×A/Victoria/3/75) was propagated in MDCK cells.
T15282 33398-33447 Sentence denotes Viral infection and determination of viral titers
T15666 35127-35373 Sentence denotes Negative controls included PBS instead of immune serum (agglutination control) or PR8 instead of X-47 virus (control for agglutination effect of sera); as positive control, serum from a mouse infected twice with a sublethal dose of X-47 was used.
T15665 35037-35126 Sentence denotes Finally, an equal volume of 0.5% chicken RBC was added and titers were read 30 min later.
T15664 34880-35036 Sentence denotes Titration was done by incubating a two-fold dilution series of sera with 4 HA units of X-47 virus for 1 hour at room temperature in 96-well U-bottom plates.
T15663 34788-34879 Sentence denotes To remove sialic acid binding proteins, sera were cleared with 1/10 volume 50% chicken RBC.
T15662 34653-34787 Sentence denotes After incubation overnight at 37°C, the RDE was inactivated by addition of 0.75% sodium citrate in PBS and heating to 56°C for 30 min.
T15661 34425-34652 Sentence denotes To determine the HAI titers in infected mice, sera of these were treated with receptor-destroying enzyme (RDE/Cholera filtrate; Sigma) to remove sialic acids from serum proteins capable of aspecific inhibition of agglutination.
T15660 34367-34424 Sentence denotes Determination of HAI (hemagglutination inhibition) titers
T14998 33274-33396 Sentence denotes A20fl/fl mice expressing or lacking the LysM-Cre transgene were termed A20myel-KO and wild type (A20myel-WT) respectively.
T14997 33192-33273 Sentence denotes A20fl/fl LysM-Cre animals were backcrossed three times to the C57Bl/6 background.
T14996 33091-33191 Sentence denotes Influenza infections were performed on age- (between 7 and 9 weeks old) and sex-matched littermates.
T14995 32941-33090 Sentence denotes Mice were housed in individually ventilated cages at the VIB Department of Molecular Biomedical Research in specific pathogen-free animal facilities.
T14994 32726-32940 Sentence denotes A20fl/fl mice were crossed with LysM-Cre mice [84] (provided by I. Förster, Institute of Genetics, University of Cologne, Germany) to generate A20fl/fl LysMCre transgenes and are described in detail elsewhere [48].
T14993 32667-32725 Sentence denotes A20fl/fl mice were generated as previously described [56].
T14992 32662-32666 Sentence denotes Mice
T14800 32541-32660 Sentence denotes Mice were anesthetized by intraperitoneal (i.p.) injection of a mixture of ketamine (12 mg/kg) and xylazine (60 mg/kg).
T14799 32483-32540 Sentence denotes All efforts were made to ameliorate suffering of animals.
T14798 32359-32482 Sentence denotes Animal protocols were approved by the ethics committee of Ghent University (permit number LA1400091, approval ID 2010/001).
T14797 32149-32358 Sentence denotes All experiments on mice were conducted according to the national (Belgian Law 14/08/1986 and 22/12/2003, Belgian Royal Decree 06/04/2010) and European (EU Directives 2010/63/EU, 86/609/EEG) animal regulations.
T14796 32132-32148 Sentence denotes Ethics statement
T11740 31972-32107 Sentence denotes Finally, similar targeting of A20 might be of interest in the battle against other viral infections including RSV and SARS coronavirus.
T11739 31897-31971 Sentence denotes Also small compound inhibitors of A20 might be an interesting alternative.
T11738 31699-31896 Sentence denotes Our results suggest that not only siRNA targeting IAV components, but boosting the antiviral immune response by intranasal administration of siRNA against A20 might be a valid therapeutic approach.
T11737 31422-31698 Sentence denotes Although specificity and tissue delivery remain major bottlenecks in the clinical applications of RNAi in general, intranasal application of siRNA against respiratory viruses including, but not limited to influenza virus, has experienced significant success and optimism [83].
T11736 31316-31421 Sentence denotes Properly designed siRNAs have been shown to function as potent inhibitors of influenza virus replication.
T11735 31176-31315 Sentence denotes In recent years, RNA interference, triggered by synthetic short interfering RNA (siRNA), has rapidly evolved as a potent antiviral regimen.
T11734 31067-31175 Sentence denotes The high mutation rate of IAV turns all attempts of vaccine and antiviral design into a never ending battle.
T11733 30897-31066 Sentence denotes About a fifth of world's population is infected by IAV annually, leading to high morbidity and mortality, particularly in infants, the elderly and the immunocompromised.
T11732 30770-30896 Sentence denotes Understanding and controlling the activation of innate antiviral immune responses is an important step toward novel therapies.
T11731 30607-30769 Sentence denotes If A20 has a similar non-redundant role in other cell types that are implicated in the response to IAV, such as lung epithelial cells, remains to be investigated.
T11730 30319-30606 Sentence denotes The clear protective phenotype of A20myel-KO mice that we here describe indicates that A20 expression in myeloid cells is a central gatekeeper of RIG-I induced signaling in response to IAV infection and that other DUBs cannot substitute for A20 deficiency under physiological conditions.
T11729 30212-30318 Sentence denotes However, evidence so far was limited to in vitro data and was obtained under non-physiological conditions.
T11728 29988-30211 Sentence denotes Multiple other deubiquitinating enzymes (DUBs), such as DUBA [28], CYLD [29], [30], OTUB1/2 [31], and A20 [49]–[52] have been shown to negatively regulate RIG-I signaling to NF-κB and IRF-3, implicating possible redundancy.
T11727 29887-29987 Sentence denotes The identification of these substrates will be the topic of future investigations in our laboratory.
T11726 29761-29886 Sentence denotes It cannot be excluded however that A20 also targets other substrates that mediate NF-κB and IRF3 activation in myeloid cells.
T11725 29576-29760 Sentence denotes So far we were unable to clearly detect ubiquitination of TBK1 and IKKε in primary macrophages, preventing us from studying the effect of A20 deficiency on their ubiquitination status.
T11724 29466-29575 Sentence denotes Whether similar mechanisms are involved in the regulation of RIG-I induced NF-κB activation is still unclear.
T11723 29193-29465 Sentence denotes In this context, it was recently shown that A20 cooperates with the ubiquitin-binding proteins TAX1BP1 and ABIN1 to to disrupt the TRAF3-TBK1-IKKε complex, thereby negatively affecting K63-polyubiquitination of TBK1 and IKKε, and their ability to activity IRF3 [81], [82].
T11722 29050-29192 Sentence denotes A20 is believed to exert its NF-κB and IRF3 inhibitory functions by modulating the ubiquitination status of different signaling proteins [80].
T11721 28907-29049 Sentence denotes However, this does not exclude an additional effect of A20 on other signaling pathways that may contribute to proinflammatory gene expression.
T11720 28664-28906 Sentence denotes We propose that A20 inhibits IAV-induced proinflammatory gene expression (as shown in our manuscript for TNF, IL-6, KC, MIP-2, and IFNβ) by negatively regulating NF-κB and IRF3 activation, which are the major pathways controlling these genes.
T11719 28448-28663 Sentence denotes RIG-I has previously been shown to play a key role in the innate immune response to IAV [13], suggesting that the increased immune response of A20myel-KO mice to IAV lung infection reflects enhanced RIG-I signaling.
T11718 28302-28447 Sentence denotes We show that A20 deficient BMDM display enhanced NF-κB and IRF3 activation in response to RIG-I stimulation by synthetic LMW double stranded RNA.
T11717 28023-28301 Sentence denotes However, the selective effect of A20 deficiency on neutrophil recruitment, without altering inflammatory monocyte (Ly6C+ CD11b+) recruitment, further support the idea that monocytes and not neutrophils are major contributors to IAV-associated immunopathology and lethality [78].
T11716 27758-28022 Sentence denotes A20myel-KO mice were protected against a lethal IAV infection, which is rather surprising since an excessive proinflammatory cytokine response and an excessive influx of inflammatory cells is generally believed to be associated with increased lethality [64], [79].
T11715 27568-27757 Sentence denotes During IAV infection these monocytes develop into inflammatory dendritic cells or proinflammatory macrophages [77] and are considered major contributors to IAV-induced immunopathology [78].
T11714 27375-27567 Sentence denotes Mice deficient for the MCP-1 receptor CCR2, which is expressed on a subset of circulating monocytes, are protected against IAV infection and display reduced signs of immunopathology [74]–[76].
T11713 27169-27374 Sentence denotes MCP-1 levels were not affected by the absence of A20 in myeloid cells, which is consistent with the notion that airway epithelial cells are the primary source of MCP-1 production during IAV infection [73].
T11712 26995-27168 Sentence denotes Although the role of neutrophils during viral infection is still under debate, recent evidence supports a protective function of these cells during IAV infection [71], [72].
T11711 26816-26994 Sentence denotes This was associated with a selective enhancement of neutrophil recruitment to the bronchoalveolar compartment, and resulted in improved viral clearance later on during infection.
T11710 26559-26815 Sentence denotes Similarly, in vivo infection with IAV resulted in higher levels of primarily neutrophil attracting chemokines such as KC and MIP-2 and several proinflammatory cytokines such as IL-6, TNF and IL-1β in the lungs of A20myel-KO mice compared to wild type mice.
T11709 26356-26558 Sentence denotes We could show that BMDM or alveolar macrophages derived from A20myel-KO mice express higher amounts of chemokines, cytokines and type I IFNs compared to wild type mice in response to in vitro infection.
T11708 26196-26355 Sentence denotes Alveolar macrophages are also known to phagocytose virus infected apoptotic cells and antibody coated viral particles, further contributing to viral clearance.
T11707 25978-26195 Sentence denotes They are an important source of proinflammatory cytokines and chemokines that attract innate immune cells to the lung during the primary phase of infection [69], and they are the primary producers of type I IFNs [70].
T11706 25802-25977 Sentence denotes However, alveolar macrophages are also crucial in the innate immune response against IAV as they are one of the first cells that encounter infectious IAV particles [67], [68].
T11705 25702-25801 Sentence denotes Under naïve conditions, alveolar macrophages exert important immunomodulatory functions [65], [66].
T11704 25555-25701 Sentence denotes In the pulmonary environment, macrophages populate both lung parenchyma and the alveolar lumen where they are referred to as alveolar macrophages.
T11703 25408-25554 Sentence denotes In the present study we have investigated the contribution of A20 expression in myeloid cells in the innate immune response to IAV lung infection.
T8751 24436-24607 Sentence denotes Collectively these data indicate that A20 deficiency in myeloid cells is associated with an increased innate immune response and protection against a lethal IAV infection.
T8750 24307-24435 Sentence denotes We could also not detect any differences in viral clearance or antiviral adaptive immunity at 6 h post infection (figure S3B–F).
T8749 24141-24306 Sentence denotes Again, MCP-1 production was not increased and even lower in A20myel-KO mice (figure 4C), and also monocyte recruitment was not different between both groups of mice.
T8748 23905-24140 Sentence denotes Also levels of the proinflammatory cytokines IL-6, TNF and IL-1β, which are often associated with immunopathogenesis in humans [64], were increased in the lungs of A20myel-KO mice compared to control animals (figure 4C and figure S3A).
T8747 23608-23904 Sentence denotes Similar to our observations with sublethal IAV infection, pulmonary KC and MIP-2 production was stronger in A20myel-KO animals compared to wild type mice following lethal IAV infection (figure 4C), which correlates with the increased numbers of neutrophils in the lungs of these mice (figure 4C).
T8746 23341-23607 Sentence denotes A20myel-KO mice still showed significant weight loss and lung damage (as reflected by increased total protein concentration in the BAL; data not shown) during the course of infection but were able to recover, in contrast to wild type mice that succumbed (figure 4B).
T8745 23198-23340 Sentence denotes Surprisingly, almost all A20myel-KO mice survived (10/11), while all control mice succumbed (0/11) within 16 days after infection (figure 4A).
T8744 22975-23197 Sentence denotes We therefore analyzed whether the increased proinflammatory cytokine production and infiltration of proinflammatory cells in A20myel-KO mice affects mortality induced by intranasal infection with a lethal dose of IAV X-47.
T8743 22862-22974 Sentence denotes It is generally believed that IAV-induced mortality is due to an excessive proinflammatory response in the lung.
T8742 22582-22861 Sentence denotes Together, these data suggest that mechanisms other than adaptive immunity, such as an increased innate immune response, characterized by an increased influx of neutrophils and increased numbers of alveolar macrophages, contribute to the better viral clearance in A20myel-KO mice.
T8741 22400-22581 Sentence denotes However, no differences could be detected between wild type and A20myel-KO animals (figure S2D), indicating that humoral immunity is not affected by A20 expression in myeloid cells.
T8740 22218-22399 Sentence denotes To test whether loss of A20 in myeloid cells affects B cell mediated immunity, we determined hemagglutinin (HA) antibody titers in the serum of A20myel-KO and wild type littermates.
T8739 22136-22217 Sentence denotes Protection against IAV infection is also provided by the humoral immune response.
T8738 21971-22135 Sentence denotes Also, the number of GrB and IFNγ CD8+ T cells as well as IFNγ expression levels in the lungs were not altered by the absence of A20 in myeloid cells (figure S2A–C).
T8737 21788-21970 Sentence denotes A clear increase in CD8+ T cells could be detected at day 7 and 10 post infection, but no differences were observed between A20myel-KO and wild type mice (figure S2A and figure S2C).
T8736 21539-21787 Sentence denotes To test whether A20 expression in myeloid cells regulates the antiviral CTL response, total CD8+ T cells and virus specific Granzyme B (GrB) and IFNγ expressing CD8+ T cells were measured in BAL and lung parenchyma of wild type and A20myel-KO mice.
T8735 21408-21538 Sentence denotes Elimination of IAV infected cells depends on the clonal expansion of virus specific cytotoxic CD8+ T cells (CTL) [61], [62], [63].
T8734 21198-21407 Sentence denotes The number of resident alveolar macrophages (autofluorescent+ CD11c+ F4/80+ CD11b−) was also elevated in A20myel-KO mice but did not differ significantly between IAV infected or mock infected mice (figure 3D).
T8733 20936-21197 Sentence denotes Although we could detect a significant increase in monocyte (CD11b+ Ly6C+) recruitment at day 4 post infection, this was not evident at later time points after infection (figure 3D), which is consistent with the equal expression of MCP-1 in both groups of mice.
T8732 20646-20935 Sentence denotes Consistent with the higher KC and MIP-2 levels in A20myel-KO mice, the number of neutrophils (CD11b+ Ly6C+ Ly6G+ F4/80−) that were recruited in the bronchoalveolar spaces upon IAV infection was clearly higher throughout infection in A20myel-KO mice compared to control animals (figure 3D).
T8731 20396-20645 Sentence denotes KC is the murine orthologue of IL-8 and serves together with MIP-2 as a chemoattractant for neutrophils, while MCP-1 is mainly known as a chemoattractant for monocytes, which eventually develop into macrophages upon entering the alveolar lumen [60].
T8730 20208-20395 Sentence denotes Unlike our observations with in vitro stimulated primary macrophages we could not detect a significant increase in MCP-1 or IFNα production in the lungs of A20myel-KO animals (figure 3C).
T8729 20023-20207 Sentence denotes Levels of KC and MIP-2 chemokines, as well as IL-6 were significantly higher at day 7 p.i. in BAL from IAV infected A20myel-KO mice compared to IAV infected wild type mice (figure 3C).
T8728 19790-20022 Sentence denotes To verify if A20 deficiency in myeloid cells affects IAV-induced gene expression in the lung, we analyzed the levels of several chemokines and cytokines in the bronchoalveolar lavage (BAL) at day 4, 7 and day 10 following infection.
T8727 18765-18922 Sentence denotes This indicates that loss of A20 in myeloid cells does not affect early viral replication but contributes to viral clearance at later stages during infection.
T8726 18563-18764 Sentence denotes However, after 10 days, almost no virus could be detected in the lungs of A20myel-KO mice while abundant infectious viral particles could still be isolated from lungs of all wild type mice (figure 3B).
T8725 18446-18562 Sentence denotes No differences in viral titers were observed in A20myel-KO mice versus wild type mice at day 4 and 7 post infection.
T8724 18369-18445 Sentence denotes Next, we measured pulmonary viral titers at 4, 7 and 10 days post infection.
T8723 18113-18368 Sentence denotes Also, total protein concentration in BAL fluid, which reflects lung damage and vascular leakage, was increased significantly at 7 and 10 days post infection in both wild type and A20myel-KO mice, and was slightly lower in A20myel-KO mice (data not shown).
T8722 17969-18112 Sentence denotes A20myel-KO mice showed reduced weight loss compared to wild type control littermates and recovered faster from the viral challenge (figure 3A).
T8721 17692-17968 Sentence denotes To determine the role of A20 expression in myeloid cells during an IAV infection in vivo, we intranasally inoculated both A20myel-KO mice and control littermates with a sublethal dose of the mouse adapted IAV X-47 (H3N2) strain and monitored morbidity in terms of weight loss.
T8720 17624-17691 Sentence denotes A20 deficiency in myeloid cells protects against IAV lung infection
T7706 17375-17622 Sentence denotes Taken together these results demonstrate that A20 negatively regulates IAV-induced proinflammatory and antiviral gene expression in alveolar macrophages, consistent with the inhibitory effect of A20 seen on RIG-I-induced NF-κB and IRF3 activation.
T7705 17103-17374 Sentence denotes Expression and secretion of the proinflammatory cytokines IL-6 and TNF, the type-I IFN IFNβ and IFNα4 and the chemokines MCP-1 (ccl2) and KC (cxcl1) was significantly higher in IAV infected cells lacking A20 compared to infected wild type cells (figure 2C and figure S1).
T7704 16897-17102 Sentence denotes To test whether A20 directly controls IAV-induced gene expression in alveolar macrophages, we isolated these cells from lungs of A20myel-KO and control littermates and infected them in vitro with IAV X-47.
T7703 16711-16896 Sentence denotes Upon host infection with IAV, alveolar macrophages are an important source of cytokines and chemokines, attracting innate immune cells to the lung during the primary phase of infection.
T7702 15696-15831 Sentence denotes In accordance with these data, cell culture supernatant collected from these cells contained higher levels of TNF and IFNβ (figure 2B).
T7701 15561-15695 Sentence denotes Furthermore, A20myel-KO BMDM show enhanced expression of IL-6 and IFNβ mRNA after IAV infection compared to control cells (figure 2A).
T7700 15440-15560 Sentence denotes A20 mRNA levels were rapidly induced in wild type BMDM, but not in A20 deficient BMDM, upon viral infection (figure 2A).
T7699 15270-15439 Sentence denotes To investigate the role of A20 in the IAV-induced proinflammatory and antiviral innate immune responses, we infected A20 deficient and control BMDM with IAV X-47 (H3N2).
T7698 15209-15269 Sentence denotes A20 negatively regulates IAV-induced gene expression in BMDM
T4749 15045-15207 Sentence denotes Together, these results demonstrate that A20 plays an important role in the negative regulation of RIG-I-induced NF-κB and IRF3 activation in primary macrophages.
T4748 14968-15044 Sentence denotes Similar results were obtained using peritoneal macrophages (data not shown).
T4747 14815-14967 Sentence denotes In line with the enhanced activation of NF-κB and IRF3 as described above, A20myel-KO BMDM secreted increased amounts of IL-6, TNF and IFNβ (figure 1D).
T4746 14717-14814 Sentence denotes NF-κB controls the expression of IL-6 and TNF, and NF-κB and IRF3 control the expression of IFNβ.
T4745 14566-14716 Sentence denotes Similar to p65, IRF3 nuclear translocation reached its maximum at an earlier time point in A20 deficient BMDM compared to wild type cells (figure 1C).
T4744 14364-14565 Sentence denotes Using immunoblotting with an antibody directed against phosphorylated Ser396, maximum IRF3 phosphorylation was detected at earlier time points in A20myel-KO BMDM compared to wild type BMDM (figure 1B).
T4743 14142-14363 Sentence denotes IRF3 is known to be activated upon phosphorylation of a series of carboxyl terminal serine residues by the IKK-like kinases TBK1 and IKKε [58], leading to its dimerization and subsequent translocation to the nucleus [59].
T4742 13944-14141 Sentence denotes Furthermore, nuclear translocation of the p65 NF-κB subunit was enhanced in poly(I:C) transfected A20myel-KO BMDM, reaching a maximum at earlier time points compared to wild type cells (figure 1C).
T4741 13774-13943 Sentence denotes Compared to wild type BMBM, A20 deficient cells showed enhanced NF-κB activation as indicated by increased phosphorylation and sustained degradation of IκBα (figure 1B).
T4740 13612-13773 Sentence denotes At early time points, slightly slower migrating forms of A20 were observed, indicating that A20 undergoes a yet unknown modification upon poly(I:C) transfection.
T4739 13473-13611 Sentence denotes As expected, poly(I:C) transfection induced the rapid expression of A20 in wild type, but not in A20myel-KO BMDM (figure 1B, upper panel).
T4738 13317-13472 Sentence denotes Of note, this concentration of poly(I:C) was unable to induce significant TLR3 dependent NF-κB and IRF3 activation or cytokine production (data not shown).
T4737 13083-13316 Sentence denotes To stimulate the RIG-I receptor, we transfected A20myel-KO BMDM and wild type control cells with minimal amounts of low molecular weight (LMW) poly(I:C), which is known to preferentially bind and activate RIG-I rather than MDA5 [57].
T4736 12857-13082 Sentence denotes Crossing these mice with transgenic mice expressing Cre recombinase under control of the lysozyme M promoter leads to specific deletion in myeloid cells and allowed us to generate myeloid cell specific A20 knockout mice [48].
T4735 12642-12856 Sentence denotes Since A20 full knockout mice die prematurely as a result of severe multi-organ inflammation [37], we generated mice carrying a conditional A20 allele in which exon IV and exon V were flanked by two loxP sites [56].
T4734 12452-12641 Sentence denotes To study the effect of endogenously expressed A20 on RIG-I-induced signaling in a more immunological relevant context, we performed further experiments in A20 deficient primary macrophages.
T4733 10981-11081 Sentence denotes These results demonstrate the potential of A20 to inhibit RIG-I-induced NF-κB and IRF3/7 activation.
T4732 10843-10980 Sentence denotes Similar to its inhibitory effect on NF-κB and IRF3 activation, A20 also prevented RIG-I-induced IRF7 activation (figure 1A, right graph).
T4731 10618-10842 Sentence denotes RIG-I (2CARD) expression in the absence of IRF7 co-expression showed negligible IFNα4 promoter activation (grey bar, figure 1A, right graph), whereas significant reporter gene expression was observed in the presence of IRF7.
T4730 10389-10617 Sentence denotes To determine the effect of A20 on IRF7 activation, we therefore transfected minor amounts of an IRF7 expression plasmid together with plasmids encoding RIG-I (2CARD), A20 and an IRF7-specific IFNα4 luciferase reporter construct.
T4729 10226-10388 Sentence denotes Unlike IRF3, IRF7 is not or weakly expressed under naïve conditions and IRF7 protein levels are rapidly upregulated upon virus-induced IRF3 activation [54], [55].
T4728 10162-10225 Sentence denotes We next investigated whether A20 also inhibits IRF7 activation.
T4727 9837-10161 Sentence denotes Similarly, we show that A20 overexpression in HEK293T cells prevents NF-κB- and IRF3-dependent luciferase reporter gene activation induced by transfection of a truncated constitutive active form of RIG-I [53], corresponding to only the two N-terminal CARD domains of RIG-I [RIG-I (2CARD)] (figure 1A, left and middle graph).
T4726 9697-9836 Sentence denotes Previous studies have shown that ectopically expressed A20 negatively regulates NF-κB and IRF3 activation upon RIG-I stimulation [50]–[52].
T4725 9496-9696 Sentence denotes RIG-I signaling induces the activation of NF-κB, IRF3 and IRF7 transcription factors, which promote the expression of proinflammatory cytokines and type I IFNs that restrict further viral propagation.
T4724 9443-9495 Sentence denotes A20 inhibits RIG-I-induced NF-κB and IRF3 activation
T945 9286-9432 Sentence denotes These results suggest that boosting the innate immune response to IAV by targeting A20 activity in myeloid cells might have therapeutic potential.
T944 9060-9285 Sentence denotes Protection against IAV in A20myel-KO mice is associated with increased cytokine and chemokine production, augmented recruitment of innate immune cells such as neutophils and alveolar macrophages, and enhanced viral clearance.
T943 8922-9059 Sentence denotes Interestingly, A20myel-KO mice show enhanced survival and reduced morbidity in response to IAV lung infection compared to wild type mice.
T942 8645-8921 Sentence denotes Using myeloid cell specific A20 knockout mice (A20myel-KO) that were recently generated in our lab and primary cells derived of these mice, we here provide evidence that A20 is a crucial negative regulator of IAV-induced proinflammatory and antiviral signaling in macrophages.
T941 8544-8644 Sentence denotes However, the precise in vivo role of A20 in the response to viral infection remains to be clarified.
T940 8165-8543 Sentence denotes In contrast to its well established function in the regulation of proinflammatory responses, the role of A20 in the regulation of antiviral immune responses is less well described and limited to a number of in vitro studies using overexpression or silencing in specific cell lines, indicating that A20 may regulate RIG-I- and TLR3-induced signaling to NF-κB and IRF-3 [49]–[52].
T939 7940-8164 Sentence denotes The relevance of these findings for human disease has recently been illustrated through the identification of polymorphisms in the A20 locus that are associated with several autoimmune diseases and chronic inflammation [45].
T938 7717-7939 Sentence denotes More recently, gene targeting of A20 in specific cell types was shown to be associated with autoimmunity and chronic inflammation [42]–[48], further illustrating that A20 is an important brake on the inflammatory response.
T937 7543-7716 Sentence denotes The anti-inflammatory role of A20 is clearly demonstrated by the fact that A20 deficient mice die early after birth due to severe multi-organ inflammation and cachexia [37].
T936 7305-7542 Sentence denotes Both catalytic and noncatalytic mechanisms were previously shown to be involved in the negative regulation of proinflammatory signaling by A20 in response to multiple receptors such as TNF receptor I [37]–[39], TLR4 [40], and IL-1R [41].
T32 1337-1587 Sentence denotes These results challenge the general belief that an excessive host proinflammatory response is associated with IAV-induced lethality, and suggest that under certain conditions inhibition of A20 might be of interest in the management of IAV infections.
T31 1239-1336 Sentence denotes Surprisingly, myeloid cell specific A20 knockout mice are protected against lethal IAV infection.
T30 1111-1238 Sentence denotes In vivo this was associated with an increased number of alveolar macrophages and neutrophils in the lungs of IAV infected mice.
T29 866-1110 Sentence denotes A20 deficient macrophages were hyperresponsive to double stranded RNA and IAV infection, as illustrated by enhanced NF-κB and IRF3 activation, concomitant with increased production of proinflammatory cytokines, chemokines and type I interferon.
T28 705-865 Sentence denotes Here we used myeloid cell specific A20 knockout mice to examine the role of the ubiquitin-editing protein A20 in the response of myeloid cells to IAV infection.
T27 551-704 Sentence denotes Understanding the mechanisms that regulate innate immune responses to IAV and other viruses is of key importance to develop novel therapeutic strategies.
T26 292-550 Sentence denotes Influenza A virus (IAV) produces double-stranded RNA as an intermediate during the replication life cycle, which activates the intracellular pathogen recognition receptor RIG-I and induces the production of proinflammatory cytokines and antiviral interferon.
T25 147-291 Sentence denotes The innate immune response provides the first line of defense against viruses and other pathogens by responding to specific microbial molecules.
T935 7199-7304 Sentence denotes Interestingly, A20 also harbors atypical zinc finger dependent K48-specific E3 ubiquitin ligase activity.
T934 7120-7198 Sentence denotes A20 is an ubiquitin-editing enzyme belonging to the OTU-domain family of DUBs.
T933 6911-7119 Sentence denotes Additionally, the attachment of K48-specific polyubiquitin chains to the IRF3 and IRF7 transcription factors by E3s such as RAUL [34], TRIM21 [35] and RBCK1 [36] further dampens antiviral signal transduction.
T932 6707-6910 Sentence denotes Furthermore, various K48-specific ubiquitin ligases, such as AIP4 [32] and TRIAD3A [33] mark respectively MAVS and TRAF3 for proteasome mediated degradation, thus inhibiting further downstream signaling.
T931 6459-6706 Sentence denotes On the other hand, deubiquitinating enzymes (DUBs), such as DUBA [28], CYLD [29], [30] and OTUB1/2 [31] have been shown to negatively regulate RLR signaling by specifically removing K63-linked polyubiquitin chains from several signaling molecules.
T930 6298-6458 Sentence denotes In addition, well characterized ubiquitin ligases such as TRAF6 [25], [26] and TRAF3 [27] mediate respectively NF-κB and IRF3 activation upon RIG-I stimulation.
T929 6163-6297 Sentence denotes K63-specific ubiquitin ligases (E3s), such as TRIM25 [22] and Riplet [23], [24], have been shown to directly promote RIG-I activation.
T928 5987-6162 Sentence denotes Signaling downstream of MAVS requires the action of various ubiquitin modifying enzymes, which both positively and negatively regulate RIG-I mediated signal transduction [21].
T927 5712-5986 Sentence denotes Upon ligand binding, the CARD domains of RIG-I associate with the CARD domain of the MAVS (also termed IPS-1, VISA, Cardif) adaptor protein, which subsequently translocates to and inserts in the outer mitochondrial membrane via its C-terminal transmembrane domain [17]–[20].
T926 5581-5711 Sentence denotes RIG-I contains a C-terminal DExD/H box helicase domain, which is required for ligand recognition, and two N-terminal CARD domains.
T925 5401-5580 Sentence denotes These results indicate that an imbalance between the beneficial and harmful effects of mediators released by immune cells is likely to contribute to the pathogenesis of influenza.
T924 5244-5400 Sentence denotes Interestingly, RIG-I deficient mice are highly susceptible to IAV [14], [15], whereas TLR3 deficient mice have a survival advantage to acute infection [16].
T923 5069-5243 Sentence denotes Both receptors contribute to the proinflammatory response to IAV, but the initiation of the innate antiviral immune response largely depends on RIG-I mediated signaling [13].
T922 4994-5068 Sentence denotes TLR3 and RIG-I have been implicated as sensors of IAV infection [10]–[12].
T921 4830-4993 Sentence denotes IAV infection leads to the exposure in the host cell of single-stranded genomic RNA and double stranded RNA, the latter being an intermediate of viral replication.
T920 4725-4829 Sentence denotes In this context, understanding of the mechanisms that regulate IAV-induced immune responses is critical.
T919 4575-4724 Sentence denotes Emergence of drug-resistant strains of influenza viruses with pandemic potential underscores the importance of developing novel antiviral strategies.
T918 4366-4574 Sentence denotes Influenza A virus (IAV) is the etiological agent of a contagious acute respiratory disease that causes considerable mortality, which is generally believed to be due to an excessive host inflammatory response.
T917 4065-4365 Sentence denotes TLR mediated antiviral responses are restricted to specialized type I IFN producing plasmacytoid dendritic cells (pDC), while most other cell types, including conventional DC (cDC), macrophages and fibroblasts, depend on the cytosolic RNA and DNA sensors for the production of antiviral proteins [9].
T916 3887-4064 Sentence denotes Intracellular DNA sensors that mediate antiviral immune responses to DNA viruses include TLR9, DAI [4] and the PYHIN domain containing proteins AIM2 [5], [6], [7] and IFI16 [8].
T915 3656-3886 Sentence denotes Endosomal Toll-like receptors (TLRs) and cytoplasmic RNA helicase RIG-I-like receptors (RLRs) or Nod-like receptors (NLRs) detect the presence of viral single stranded (TLR7, TLR8, Nod2) or double stranded RNA (TLR3, RIG-I, MDA5).
T914 3476-3655 Sentence denotes The presence of viral nucleic acids, such as viral RNA and DNA, viral replication intermediates and viral transcription products, can be sensed by specific intracellular PRRs [3].
T913 3178-3475 Sentence denotes Triggering of PRRs induces the production of host proinflammatory cytokines (e.g. TNF, IL-6 and IL-1) and type I interferons (interferon-α (IFN-α) and IFN-β) through activation of downstream signaling pathways that control various transcription factors such as NF-κB, AP-1, IRF3 and IRF7 [1], [2].
T912 2972-3177 Sentence denotes The initiation of a protective innate antiviral immune response involves the action of specialized pattern recognition receptors (PRR), which detect conserved molecular structures of the invading pathogen.
T911 2871-2971 Sentence denotes Viruses are a class of highly diverse pathogens which depend on the host cell for their replication.
T1 0-86 Sentence denotes A20 (Tnfaip3) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection
T2 87-136 Sentence denotes Loss of A20 in Myeloid Cells Protects against IAV
T3 138-146 Sentence denotes Abstract
T4 147-291 Sentence denotes The innate immune response provides the first line of defense against viruses and other pathogens by responding to specific microbial molecules.
T5 292-550 Sentence denotes Influenza A virus (IAV) produces double-stranded RNA as an intermediate during the replication life cycle, which activates the intracellular pathogen recognition receptor RIG-I and induces the production of proinflammatory cytokines and antiviral interferon.
T6 551-704 Sentence denotes Understanding the mechanisms that regulate innate immune responses to IAV and other viruses is of key importance to develop novel therapeutic strategies.
T7 705-865 Sentence denotes Here we used myeloid cell specific A20 knockout mice to examine the role of the ubiquitin-editing protein A20 in the response of myeloid cells to IAV infection.
T8 866-1110 Sentence denotes A20 deficient macrophages were hyperresponsive to double stranded RNA and IAV infection, as illustrated by enhanced NF-κB and IRF3 activation, concomitant with increased production of proinflammatory cytokines, chemokines and type I interferon.
T9 1111-1238 Sentence denotes In vivo this was associated with an increased number of alveolar macrophages and neutrophils in the lungs of IAV infected mice.
T10 1239-1336 Sentence denotes Surprisingly, myeloid cell specific A20 knockout mice are protected against lethal IAV infection.
T11 1337-1587 Sentence denotes These results challenge the general belief that an excessive host proinflammatory response is associated with IAV-induced lethality, and suggest that under certain conditions inhibition of A20 might be of interest in the management of IAV infections.
T12 1589-1603 Sentence denotes Author Summary
T13 1604-1806 Sentence denotes Influenza virus or flu epidemics represent a recurrent threat to the public health, especially for individuals which are part of a high-risk group such as children, elderly or immune-compromised people.
T14 1807-1930 Sentence denotes Sporadic pandemic flu outbreaks, such as the Spanish flu of 1918, may cause high grades of mortality among healthy persons.
T15 1931-2027 Sentence denotes A better understanding of how the immune system deals with these pathogens is of key importance.
T16 2028-2124 Sentence denotes The protein A20 is an important negative regulator of both innate and adaptive immune responses.
T17 2125-2292 Sentence denotes We show that the specific deletion of A20 in myeloid cells, such as macrophages and neutrophils, improves the resistance against otherwise lethal influenza infections.
T18 2293-2419 Sentence denotes This protective effect is mediated by an enhanced innate immune response following respiratory challenge with influenza virus.
T19 2420-2725 Sentence denotes Although exaggerated pulmonary immune responses are believed to be the primary cause of often life threatening influenza virus induced pneumonia, we demonstrate that boosting the innate immune response by selectively targeting the functionality of A20 in myeloid cells is beneficial for the host survival.
T20 2726-2856 Sentence denotes This finding provides us with a novel valuable approach for treating influenza and potentially other respiratory viral infections.
T21 2858-2870 Sentence denotes Introduction
T22 2871-2971 Sentence denotes Viruses are a class of highly diverse pathogens which depend on the host cell for their replication.
T23 2972-3177 Sentence denotes The initiation of a protective innate antiviral immune response involves the action of specialized pattern recognition receptors (PRR), which detect conserved molecular structures of the invading pathogen.
T24 3178-3475 Sentence denotes Triggering of PRRs induces the production of host proinflammatory cytokines (e.g. TNF, IL-6 and IL-1) and type I interferons (interferon-α (IFN-α) and IFN-β) through activation of downstream signaling pathways that control various transcription factors such as NF-κB, AP-1, IRF3 and IRF7 [1], [2].
T25 3476-3655 Sentence denotes The presence of viral nucleic acids, such as viral RNA and DNA, viral replication intermediates and viral transcription products, can be sensed by specific intracellular PRRs [3].
T26 3656-3886 Sentence denotes Endosomal Toll-like receptors (TLRs) and cytoplasmic RNA helicase RIG-I-like receptors (RLRs) or Nod-like receptors (NLRs) detect the presence of viral single stranded (TLR7, TLR8, Nod2) or double stranded RNA (TLR3, RIG-I, MDA5).
T27 3887-4064 Sentence denotes Intracellular DNA sensors that mediate antiviral immune responses to DNA viruses include TLR9, DAI [4] and the PYHIN domain containing proteins AIM2 [5], [6], [7] and IFI16 [8].
T28 4065-4365 Sentence denotes TLR mediated antiviral responses are restricted to specialized type I IFN producing plasmacytoid dendritic cells (pDC), while most other cell types, including conventional DC (cDC), macrophages and fibroblasts, depend on the cytosolic RNA and DNA sensors for the production of antiviral proteins [9].
T29 4366-4574 Sentence denotes Influenza A virus (IAV) is the etiological agent of a contagious acute respiratory disease that causes considerable mortality, which is generally believed to be due to an excessive host inflammatory response.
T30 4575-4724 Sentence denotes Emergence of drug-resistant strains of influenza viruses with pandemic potential underscores the importance of developing novel antiviral strategies.
T31 4725-4829 Sentence denotes In this context, understanding of the mechanisms that regulate IAV-induced immune responses is critical.
T32 4830-4993 Sentence denotes IAV infection leads to the exposure in the host cell of single-stranded genomic RNA and double stranded RNA, the latter being an intermediate of viral replication.
T33 4994-5068 Sentence denotes TLR3 and RIG-I have been implicated as sensors of IAV infection [10]–[12].
T34 5069-5243 Sentence denotes Both receptors contribute to the proinflammatory response to IAV, but the initiation of the innate antiviral immune response largely depends on RIG-I mediated signaling [13].
T35 5244-5400 Sentence denotes Interestingly, RIG-I deficient mice are highly susceptible to IAV [14], [15], whereas TLR3 deficient mice have a survival advantage to acute infection [16].
T36 5401-5580 Sentence denotes These results indicate that an imbalance between the beneficial and harmful effects of mediators released by immune cells is likely to contribute to the pathogenesis of influenza.
T37 5581-5711 Sentence denotes RIG-I contains a C-terminal DExD/H box helicase domain, which is required for ligand recognition, and two N-terminal CARD domains.
T38 5712-5986 Sentence denotes Upon ligand binding, the CARD domains of RIG-I associate with the CARD domain of the MAVS (also termed IPS-1, VISA, Cardif) adaptor protein, which subsequently translocates to and inserts in the outer mitochondrial membrane via its C-terminal transmembrane domain [17]–[20].
T39 5987-6162 Sentence denotes Signaling downstream of MAVS requires the action of various ubiquitin modifying enzymes, which both positively and negatively regulate RIG-I mediated signal transduction [21].
T40 6163-6297 Sentence denotes K63-specific ubiquitin ligases (E3s), such as TRIM25 [22] and Riplet [23], [24], have been shown to directly promote RIG-I activation.
T41 6298-6458 Sentence denotes In addition, well characterized ubiquitin ligases such as TRAF6 [25], [26] and TRAF3 [27] mediate respectively NF-κB and IRF3 activation upon RIG-I stimulation.
T42 6459-6706 Sentence denotes On the other hand, deubiquitinating enzymes (DUBs), such as DUBA [28], CYLD [29], [30] and OTUB1/2 [31] have been shown to negatively regulate RLR signaling by specifically removing K63-linked polyubiquitin chains from several signaling molecules.
T43 6707-6910 Sentence denotes Furthermore, various K48-specific ubiquitin ligases, such as AIP4 [32] and TRIAD3A [33] mark respectively MAVS and TRAF3 for proteasome mediated degradation, thus inhibiting further downstream signaling.
T44 6911-7119 Sentence denotes Additionally, the attachment of K48-specific polyubiquitin chains to the IRF3 and IRF7 transcription factors by E3s such as RAUL [34], TRIM21 [35] and RBCK1 [36] further dampens antiviral signal transduction.
T45 7120-7198 Sentence denotes A20 is an ubiquitin-editing enzyme belonging to the OTU-domain family of DUBs.
T46 7199-7304 Sentence denotes Interestingly, A20 also harbors atypical zinc finger dependent K48-specific E3 ubiquitin ligase activity.
T47 7305-7542 Sentence denotes Both catalytic and noncatalytic mechanisms were previously shown to be involved in the negative regulation of proinflammatory signaling by A20 in response to multiple receptors such as TNF receptor I [37]–[39], TLR4 [40], and IL-1R [41].
T48 7543-7716 Sentence denotes The anti-inflammatory role of A20 is clearly demonstrated by the fact that A20 deficient mice die early after birth due to severe multi-organ inflammation and cachexia [37].
T49 7717-7939 Sentence denotes More recently, gene targeting of A20 in specific cell types was shown to be associated with autoimmunity and chronic inflammation [42]–[48], further illustrating that A20 is an important brake on the inflammatory response.
T50 7940-8164 Sentence denotes The relevance of these findings for human disease has recently been illustrated through the identification of polymorphisms in the A20 locus that are associated with several autoimmune diseases and chronic inflammation [45].
T51 8165-8543 Sentence denotes In contrast to its well established function in the regulation of proinflammatory responses, the role of A20 in the regulation of antiviral immune responses is less well described and limited to a number of in vitro studies using overexpression or silencing in specific cell lines, indicating that A20 may regulate RIG-I- and TLR3-induced signaling to NF-κB and IRF-3 [49]–[52].
T52 8544-8644 Sentence denotes However, the precise in vivo role of A20 in the response to viral infection remains to be clarified.
T53 8645-8921 Sentence denotes Using myeloid cell specific A20 knockout mice (A20myel-KO) that were recently generated in our lab and primary cells derived of these mice, we here provide evidence that A20 is a crucial negative regulator of IAV-induced proinflammatory and antiviral signaling in macrophages.
T54 8922-9059 Sentence denotes Interestingly, A20myel-KO mice show enhanced survival and reduced morbidity in response to IAV lung infection compared to wild type mice.
T55 9060-9285 Sentence denotes Protection against IAV in A20myel-KO mice is associated with increased cytokine and chemokine production, augmented recruitment of innate immune cells such as neutophils and alveolar macrophages, and enhanced viral clearance.
T56 9286-9432 Sentence denotes These results suggest that boosting the innate immune response to IAV by targeting A20 activity in myeloid cells might have therapeutic potential.
T57 9434-9441 Sentence denotes Results
T58 9443-9495 Sentence denotes A20 inhibits RIG-I-induced NF-κB and IRF3 activation
T59 9496-9696 Sentence denotes RIG-I signaling induces the activation of NF-κB, IRF3 and IRF7 transcription factors, which promote the expression of proinflammatory cytokines and type I IFNs that restrict further viral propagation.
T60 9697-9836 Sentence denotes Previous studies have shown that ectopically expressed A20 negatively regulates NF-κB and IRF3 activation upon RIG-I stimulation [50]–[52].
T61 9837-10161 Sentence denotes Similarly, we show that A20 overexpression in HEK293T cells prevents NF-κB- and IRF3-dependent luciferase reporter gene activation induced by transfection of a truncated constitutive active form of RIG-I [53], corresponding to only the two N-terminal CARD domains of RIG-I [RIG-I (2CARD)] (figure 1A, left and middle graph).
T62 10162-10225 Sentence denotes We next investigated whether A20 also inhibits IRF7 activation.
T63 10226-10388 Sentence denotes Unlike IRF3, IRF7 is not or weakly expressed under naïve conditions and IRF7 protein levels are rapidly upregulated upon virus-induced IRF3 activation [54], [55].
T64 10389-10617 Sentence denotes To determine the effect of A20 on IRF7 activation, we therefore transfected minor amounts of an IRF7 expression plasmid together with plasmids encoding RIG-I (2CARD), A20 and an IRF7-specific IFNα4 luciferase reporter construct.
T65 10618-10842 Sentence denotes RIG-I (2CARD) expression in the absence of IRF7 co-expression showed negligible IFNα4 promoter activation (grey bar, figure 1A, right graph), whereas significant reporter gene expression was observed in the presence of IRF7.
T66 10843-10980 Sentence denotes Similar to its inhibitory effect on NF-κB and IRF3 activation, A20 also prevented RIG-I-induced IRF7 activation (figure 1A, right graph).
T67 10981-11081 Sentence denotes These results demonstrate the potential of A20 to inhibit RIG-I-induced NF-κB and IRF3/7 activation.
T68 11082-11198 Sentence denotes 10.1371/journal.ppat.1002570.g001 Figure 1 A20 inhibits NF-κB and IRF3 activation in response to RIG-I stimulation.
T69 11199-11415 Sentence denotes (A) HEK293T cells were transfected with NF-κB (left), IRF3 (middle) or IRF7 dependent luciferase reporter (right) plasmids, together with plasmids expressing RIG-I (2CARD), IRF7 (right) and increasing amounts of A20.
T70 11416-11483 Sentence denotes Luciferase activity in cell extracts was analyzed in a luminometer.
T71 11484-11814 Sentence denotes Numbers are averages +/− SD of 3 samples per set-up. (B–D) A20myel-KO and wild type (A20myel-WT) BMDM were transfected with LMW poly(I:C) and analyzed at different time points (minutes) after the start of transfection for IκBα phosphorylation and degradation, and IRF3 phosphorylation by immunoblotting of total cell extracts (B).
T72 11815-11946 Sentence denotes The band that is non-specifically recognized by the anti-IκBα antibody (indicated by an asterisk) can be used as a loading control.
T73 11947-12064 Sentence denotes Nuclear translocation of NF-κB (p65) and IRF3 was analyzed by immunoblotting of cytoplasmic or nuclear fractions (C).
T74 12065-12214 Sentence denotes Quantification of band density for nuclear p65 and IRF3 is shown in bar graphs (expressed as relative density compared to the first lane;  = time 0).
T75 12215-12397 Sentence denotes IL-6, TNF and IFNβ levels in the supernatant of cells used in (B) were determined by bioassay (IL-6) and ELISA (TNF and IFNβ) as described in the ‘materials and methods’ section (D).
T76 12398-12451 Sentence denotes Data are representative of 2 independent experiments.
T77 12452-12641 Sentence denotes To study the effect of endogenously expressed A20 on RIG-I-induced signaling in a more immunological relevant context, we performed further experiments in A20 deficient primary macrophages.
T78 12642-12856 Sentence denotes Since A20 full knockout mice die prematurely as a result of severe multi-organ inflammation [37], we generated mice carrying a conditional A20 allele in which exon IV and exon V were flanked by two loxP sites [56].
T79 12857-13082 Sentence denotes Crossing these mice with transgenic mice expressing Cre recombinase under control of the lysozyme M promoter leads to specific deletion in myeloid cells and allowed us to generate myeloid cell specific A20 knockout mice [48].
T80 13083-13316 Sentence denotes To stimulate the RIG-I receptor, we transfected A20myel-KO BMDM and wild type control cells with minimal amounts of low molecular weight (LMW) poly(I:C), which is known to preferentially bind and activate RIG-I rather than MDA5 [57].
T81 13317-13472 Sentence denotes Of note, this concentration of poly(I:C) was unable to induce significant TLR3 dependent NF-κB and IRF3 activation or cytokine production (data not shown).
T82 13473-13611 Sentence denotes As expected, poly(I:C) transfection induced the rapid expression of A20 in wild type, but not in A20myel-KO BMDM (figure 1B, upper panel).
T83 13612-13773 Sentence denotes At early time points, slightly slower migrating forms of A20 were observed, indicating that A20 undergoes a yet unknown modification upon poly(I:C) transfection.
T84 13774-13943 Sentence denotes Compared to wild type BMBM, A20 deficient cells showed enhanced NF-κB activation as indicated by increased phosphorylation and sustained degradation of IκBα (figure 1B).
T85 13944-14141 Sentence denotes Furthermore, nuclear translocation of the p65 NF-κB subunit was enhanced in poly(I:C) transfected A20myel-KO BMDM, reaching a maximum at earlier time points compared to wild type cells (figure 1C).
T86 14142-14363 Sentence denotes IRF3 is known to be activated upon phosphorylation of a series of carboxyl terminal serine residues by the IKK-like kinases TBK1 and IKKε [58], leading to its dimerization and subsequent translocation to the nucleus [59].
T87 14364-14565 Sentence denotes Using immunoblotting with an antibody directed against phosphorylated Ser396, maximum IRF3 phosphorylation was detected at earlier time points in A20myel-KO BMDM compared to wild type BMDM (figure 1B).
T88 14566-14716 Sentence denotes Similar to p65, IRF3 nuclear translocation reached its maximum at an earlier time point in A20 deficient BMDM compared to wild type cells (figure 1C).
T89 14717-14814 Sentence denotes NF-κB controls the expression of IL-6 and TNF, and NF-κB and IRF3 control the expression of IFNβ.
T90 14815-14967 Sentence denotes In line with the enhanced activation of NF-κB and IRF3 as described above, A20myel-KO BMDM secreted increased amounts of IL-6, TNF and IFNβ (figure 1D).
T91 14968-15044 Sentence denotes Similar results were obtained using peritoneal macrophages (data not shown).
T92 15045-15207 Sentence denotes Together, these results demonstrate that A20 plays an important role in the negative regulation of RIG-I-induced NF-κB and IRF3 activation in primary macrophages.
T93 15209-15269 Sentence denotes A20 negatively regulates IAV-induced gene expression in BMDM
T94 15270-15439 Sentence denotes To investigate the role of A20 in the IAV-induced proinflammatory and antiviral innate immune responses, we infected A20 deficient and control BMDM with IAV X-47 (H3N2).
T95 15440-15560 Sentence denotes A20 mRNA levels were rapidly induced in wild type BMDM, but not in A20 deficient BMDM, upon viral infection (figure 2A).
T96 15561-15695 Sentence denotes Furthermore, A20myel-KO BMDM show enhanced expression of IL-6 and IFNβ mRNA after IAV infection compared to control cells (figure 2A).
T97 15696-15831 Sentence denotes In accordance with these data, cell culture supernatant collected from these cells contained higher levels of TNF and IFNβ (figure 2B).
T98 15832-15962 Sentence denotes 10.1371/journal.ppat.1002570.g002 Figure 2 A20 negatively regulates IAV-induced gene expression in BMDM and alveolar macrophages.
T99 15963-16053 Sentence denotes (A–B) BMDM isolated from A20myel-WT and A20myel-KO animals were infected with IAV (moi 1).
T100 16054-16182 Sentence denotes At different hours post infection (hours p.i.) cells were lysed and IL-6, IFNβ and A20 mRNA expression was analyzed by qPCR (A).
T101 16183-16408 Sentence denotes 18 hours post infection cell culture supernatant was analyzed for TNF and IFNβ protein levels by ELISA and multiplexing technologies (B). (C–D) Alveolar macrophages were mock treated or infected with IAV (moi 1) for 18 hours.
T102 16409-16466 Sentence denotes IL-6 and IFNβ mRNA expression was determined by qPCR (C).
T103 16467-16581 Sentence denotes Cell culture supernatant was analyzed for IL-6 and IFNβ protein levels by ELISA and multiplexing technologies (D).
T104 16582-16640 Sentence denotes Error bars represent mean values (+/− SEM) of 2–3 samples.
T105 16641-16710 Sentence denotes Results are representative for 2 independent experiments. ***p<0,001.
T106 16711-16896 Sentence denotes Upon host infection with IAV, alveolar macrophages are an important source of cytokines and chemokines, attracting innate immune cells to the lung during the primary phase of infection.
T107 16897-17102 Sentence denotes To test whether A20 directly controls IAV-induced gene expression in alveolar macrophages, we isolated these cells from lungs of A20myel-KO and control littermates and infected them in vitro with IAV X-47.
T108 17103-17374 Sentence denotes Expression and secretion of the proinflammatory cytokines IL-6 and TNF, the type-I IFN IFNβ and IFNα4 and the chemokines MCP-1 (ccl2) and KC (cxcl1) was significantly higher in IAV infected cells lacking A20 compared to infected wild type cells (figure 2C and figure S1).
T109 17375-17622 Sentence denotes Taken together these results demonstrate that A20 negatively regulates IAV-induced proinflammatory and antiviral gene expression in alveolar macrophages, consistent with the inhibitory effect of A20 seen on RIG-I-induced NF-κB and IRF3 activation.
T110 17624-17691 Sentence denotes A20 deficiency in myeloid cells protects against IAV lung infection
T111 17692-17968 Sentence denotes To determine the role of A20 expression in myeloid cells during an IAV infection in vivo, we intranasally inoculated both A20myel-KO mice and control littermates with a sublethal dose of the mouse adapted IAV X-47 (H3N2) strain and monitored morbidity in terms of weight loss.
T112 17969-18112 Sentence denotes A20myel-KO mice showed reduced weight loss compared to wild type control littermates and recovered faster from the viral challenge (figure 3A).
T113 18113-18368 Sentence denotes Also, total protein concentration in BAL fluid, which reflects lung damage and vascular leakage, was increased significantly at 7 and 10 days post infection in both wild type and A20myel-KO mice, and was slightly lower in A20myel-KO mice (data not shown).
T114 18369-18445 Sentence denotes Next, we measured pulmonary viral titers at 4, 7 and 10 days post infection.
T115 18446-18562 Sentence denotes No differences in viral titers were observed in A20myel-KO mice versus wild type mice at day 4 and 7 post infection.
T116 18563-18764 Sentence denotes However, after 10 days, almost no virus could be detected in the lungs of A20myel-KO mice while abundant infectious viral particles could still be isolated from lungs of all wild type mice (figure 3B).
T117 18765-18922 Sentence denotes This indicates that loss of A20 in myeloid cells does not affect early viral replication but contributes to viral clearance at later stages during infection.
T118 18923-19035 Sentence denotes 10.1371/journal.ppat.1002570.g003 Figure 3 A20 deficiency in myeloid cells protects against IAV lung infection.
T119 19036-19157 Sentence denotes A20myel-WT and A20myel-KO mice were infected intranasally with a sublethal dose of IAV and weight loss was monitored (A).
T120 19158-19271 Sentence denotes At day 4, 7 and 10 post infection (p.i.) viral titers in the lung were measured and expressed as mean TCID50 (B).
T121 19272-19319 Sentence denotes The dashed line represents the detection limit.
T122 19320-19339 Sentence denotes ND, not detectable.
T123 19340-19513 Sentence denotes BAL was isolated from IAV infected mice at 4, 7 and 10 days p.i. and KC, MIP-2, MCP-1, IL-6 and IFNα protein levels were analyzed by ELISA and multiplexing technologies (C).
T124 19514-19659 Sentence denotes Absolute numbers of resident alveolar macrophages, neutrophils and monocytes in BAL were analyzed by flow cytometry at 4, 7 and 10 days p.i. (D).
T125 19660-19789 Sentence denotes Numbers are averages +/− SEM of at least 5 mice per group and are representative of 2 independent experiments. *p<0.05; **p<0.01.
T126 19790-20022 Sentence denotes To verify if A20 deficiency in myeloid cells affects IAV-induced gene expression in the lung, we analyzed the levels of several chemokines and cytokines in the bronchoalveolar lavage (BAL) at day 4, 7 and day 10 following infection.
T127 20023-20207 Sentence denotes Levels of KC and MIP-2 chemokines, as well as IL-6 were significantly higher at day 7 p.i. in BAL from IAV infected A20myel-KO mice compared to IAV infected wild type mice (figure 3C).
T128 20208-20395 Sentence denotes Unlike our observations with in vitro stimulated primary macrophages we could not detect a significant increase in MCP-1 or IFNα production in the lungs of A20myel-KO animals (figure 3C).
T129 20396-20645 Sentence denotes KC is the murine orthologue of IL-8 and serves together with MIP-2 as a chemoattractant for neutrophils, while MCP-1 is mainly known as a chemoattractant for monocytes, which eventually develop into macrophages upon entering the alveolar lumen [60].
T130 20646-20935 Sentence denotes Consistent with the higher KC and MIP-2 levels in A20myel-KO mice, the number of neutrophils (CD11b+ Ly6C+ Ly6G+ F4/80−) that were recruited in the bronchoalveolar spaces upon IAV infection was clearly higher throughout infection in A20myel-KO mice compared to control animals (figure 3D).
T131 20936-21197 Sentence denotes Although we could detect a significant increase in monocyte (CD11b+ Ly6C+) recruitment at day 4 post infection, this was not evident at later time points after infection (figure 3D), which is consistent with the equal expression of MCP-1 in both groups of mice.
T132 21198-21407 Sentence denotes The number of resident alveolar macrophages (autofluorescent+ CD11c+ F4/80+ CD11b−) was also elevated in A20myel-KO mice but did not differ significantly between IAV infected or mock infected mice (figure 3D).
T133 21408-21538 Sentence denotes Elimination of IAV infected cells depends on the clonal expansion of virus specific cytotoxic CD8+ T cells (CTL) [61], [62], [63].
T134 21539-21787 Sentence denotes To test whether A20 expression in myeloid cells regulates the antiviral CTL response, total CD8+ T cells and virus specific Granzyme B (GrB) and IFNγ expressing CD8+ T cells were measured in BAL and lung parenchyma of wild type and A20myel-KO mice.
T135 21788-21970 Sentence denotes A clear increase in CD8+ T cells could be detected at day 7 and 10 post infection, but no differences were observed between A20myel-KO and wild type mice (figure S2A and figure S2C).
T136 21971-22135 Sentence denotes Also, the number of GrB and IFNγ CD8+ T cells as well as IFNγ expression levels in the lungs were not altered by the absence of A20 in myeloid cells (figure S2A–C).
T137 22136-22217 Sentence denotes Protection against IAV infection is also provided by the humoral immune response.
T138 22218-22399 Sentence denotes To test whether loss of A20 in myeloid cells affects B cell mediated immunity, we determined hemagglutinin (HA) antibody titers in the serum of A20myel-KO and wild type littermates.
T139 22400-22581 Sentence denotes However, no differences could be detected between wild type and A20myel-KO animals (figure S2D), indicating that humoral immunity is not affected by A20 expression in myeloid cells.
T140 22582-22861 Sentence denotes Together, these data suggest that mechanisms other than adaptive immunity, such as an increased innate immune response, characterized by an increased influx of neutrophils and increased numbers of alveolar macrophages, contribute to the better viral clearance in A20myel-KO mice.
T141 22862-22974 Sentence denotes It is generally believed that IAV-induced mortality is due to an excessive proinflammatory response in the lung.
T142 22975-23197 Sentence denotes We therefore analyzed whether the increased proinflammatory cytokine production and infiltration of proinflammatory cells in A20myel-KO mice affects mortality induced by intranasal infection with a lethal dose of IAV X-47.
T143 23198-23340 Sentence denotes Surprisingly, almost all A20myel-KO mice survived (10/11), while all control mice succumbed (0/11) within 16 days after infection (figure 4A).
T144 23341-23607 Sentence denotes A20myel-KO mice still showed significant weight loss and lung damage (as reflected by increased total protein concentration in the BAL; data not shown) during the course of infection but were able to recover, in contrast to wild type mice that succumbed (figure 4B).
T145 23608-23904 Sentence denotes Similar to our observations with sublethal IAV infection, pulmonary KC and MIP-2 production was stronger in A20myel-KO animals compared to wild type mice following lethal IAV infection (figure 4C), which correlates with the increased numbers of neutrophils in the lungs of these mice (figure 4C).
T146 23905-24140 Sentence denotes Also levels of the proinflammatory cytokines IL-6, TNF and IL-1β, which are often associated with immunopathogenesis in humans [64], were increased in the lungs of A20myel-KO mice compared to control animals (figure 4C and figure S3A).
T147 24141-24306 Sentence denotes Again, MCP-1 production was not increased and even lower in A20myel-KO mice (figure 4C), and also monocyte recruitment was not different between both groups of mice.
T148 24307-24435 Sentence denotes We could also not detect any differences in viral clearance or antiviral adaptive immunity at 6 h post infection (figure S3B–F).
T149 24436-24607 Sentence denotes Collectively these data indicate that A20 deficiency in myeloid cells is associated with an increased innate immune response and protection against a lethal IAV infection.
T150 24608-24722 Sentence denotes 10.1371/journal.ppat.1002570.g004 Figure 4 A20 deficiency in myeloid cells protects against lethal IAV infection.
T151 24723-24930 Sentence denotes A20myel-WT (n = 11) and A20myel-KO (n = 11) mice were intranasally infected with a lethal dose of IAV and survival (p<0.001) (A) and weight loss +/− SEM (B) was monitored for respectively 21 and 15 days p.i.
T152 24931-25124 Sentence denotes BAL fluid was collected from wild type (A20myel-WT) and A20myel-KO mice 6 days following infection with a lethal dose IAV and KC, MIP-2, MCP-1, IL-6 and IFNα protein levels were determined (C).
T153 25125-25251 Sentence denotes Absolute numbers of alveolar macrophages, neutrophils and monocytes in BAL were analyzed by flow cytometry at 6 days p.i. (D).
T154 25252-25310 Sentence denotes Numbers are averages +/− SEM of at least 5 mice per group.
T155 25311-25395 Sentence denotes Data are representative of 2 independent experiments. *p<0.05; **p<0.01, ***p<0.001.
T156 25397-25407 Sentence denotes Discussion
T157 25408-25554 Sentence denotes In the present study we have investigated the contribution of A20 expression in myeloid cells in the innate immune response to IAV lung infection.
T158 25555-25701 Sentence denotes In the pulmonary environment, macrophages populate both lung parenchyma and the alveolar lumen where they are referred to as alveolar macrophages.
T159 25702-25801 Sentence denotes Under naïve conditions, alveolar macrophages exert important immunomodulatory functions [65], [66].
T160 25802-25977 Sentence denotes However, alveolar macrophages are also crucial in the innate immune response against IAV as they are one of the first cells that encounter infectious IAV particles [67], [68].
T161 25978-26195 Sentence denotes They are an important source of proinflammatory cytokines and chemokines that attract innate immune cells to the lung during the primary phase of infection [69], and they are the primary producers of type I IFNs [70].
T162 26196-26355 Sentence denotes Alveolar macrophages are also known to phagocytose virus infected apoptotic cells and antibody coated viral particles, further contributing to viral clearance.
T163 26356-26558 Sentence denotes We could show that BMDM or alveolar macrophages derived from A20myel-KO mice express higher amounts of chemokines, cytokines and type I IFNs compared to wild type mice in response to in vitro infection.
T164 26559-26815 Sentence denotes Similarly, in vivo infection with IAV resulted in higher levels of primarily neutrophil attracting chemokines such as KC and MIP-2 and several proinflammatory cytokines such as IL-6, TNF and IL-1β in the lungs of A20myel-KO mice compared to wild type mice.
T165 26816-26994 Sentence denotes This was associated with a selective enhancement of neutrophil recruitment to the bronchoalveolar compartment, and resulted in improved viral clearance later on during infection.
T166 26995-27168 Sentence denotes Although the role of neutrophils during viral infection is still under debate, recent evidence supports a protective function of these cells during IAV infection [71], [72].
T167 27169-27374 Sentence denotes MCP-1 levels were not affected by the absence of A20 in myeloid cells, which is consistent with the notion that airway epithelial cells are the primary source of MCP-1 production during IAV infection [73].
T168 27375-27567 Sentence denotes Mice deficient for the MCP-1 receptor CCR2, which is expressed on a subset of circulating monocytes, are protected against IAV infection and display reduced signs of immunopathology [74]–[76].
T169 27568-27757 Sentence denotes During IAV infection these monocytes develop into inflammatory dendritic cells or proinflammatory macrophages [77] and are considered major contributors to IAV-induced immunopathology [78].
T170 27758-28022 Sentence denotes A20myel-KO mice were protected against a lethal IAV infection, which is rather surprising since an excessive proinflammatory cytokine response and an excessive influx of inflammatory cells is generally believed to be associated with increased lethality [64], [79].
T171 28023-28301 Sentence denotes However, the selective effect of A20 deficiency on neutrophil recruitment, without altering inflammatory monocyte (Ly6C+ CD11b+) recruitment, further support the idea that monocytes and not neutrophils are major contributors to IAV-associated immunopathology and lethality [78].
T172 28302-28447 Sentence denotes We show that A20 deficient BMDM display enhanced NF-κB and IRF3 activation in response to RIG-I stimulation by synthetic LMW double stranded RNA.
T173 28448-28663 Sentence denotes RIG-I has previously been shown to play a key role in the innate immune response to IAV [13], suggesting that the increased immune response of A20myel-KO mice to IAV lung infection reflects enhanced RIG-I signaling.
T174 28664-28906 Sentence denotes We propose that A20 inhibits IAV-induced proinflammatory gene expression (as shown in our manuscript for TNF, IL-6, KC, MIP-2, and IFNβ) by negatively regulating NF-κB and IRF3 activation, which are the major pathways controlling these genes.
T175 28907-29049 Sentence denotes However, this does not exclude an additional effect of A20 on other signaling pathways that may contribute to proinflammatory gene expression.
T176 29050-29192 Sentence denotes A20 is believed to exert its NF-κB and IRF3 inhibitory functions by modulating the ubiquitination status of different signaling proteins [80].
T177 29193-29465 Sentence denotes In this context, it was recently shown that A20 cooperates with the ubiquitin-binding proteins TAX1BP1 and ABIN1 to to disrupt the TRAF3-TBK1-IKKε complex, thereby negatively affecting K63-polyubiquitination of TBK1 and IKKε, and their ability to activity IRF3 [81], [82].
T178 29466-29575 Sentence denotes Whether similar mechanisms are involved in the regulation of RIG-I induced NF-κB activation is still unclear.
T179 29576-29760 Sentence denotes So far we were unable to clearly detect ubiquitination of TBK1 and IKKε in primary macrophages, preventing us from studying the effect of A20 deficiency on their ubiquitination status.
T180 29761-29886 Sentence denotes It cannot be excluded however that A20 also targets other substrates that mediate NF-κB and IRF3 activation in myeloid cells.
T181 29887-29987 Sentence denotes The identification of these substrates will be the topic of future investigations in our laboratory.
T182 29988-30211 Sentence denotes Multiple other deubiquitinating enzymes (DUBs), such as DUBA [28], CYLD [29], [30], OTUB1/2 [31], and A20 [49]–[52] have been shown to negatively regulate RIG-I signaling to NF-κB and IRF-3, implicating possible redundancy.
T183 30212-30318 Sentence denotes However, evidence so far was limited to in vitro data and was obtained under non-physiological conditions.
T184 30319-30606 Sentence denotes The clear protective phenotype of A20myel-KO mice that we here describe indicates that A20 expression in myeloid cells is a central gatekeeper of RIG-I induced signaling in response to IAV infection and that other DUBs cannot substitute for A20 deficiency under physiological conditions.
T185 30607-30769 Sentence denotes If A20 has a similar non-redundant role in other cell types that are implicated in the response to IAV, such as lung epithelial cells, remains to be investigated.
T186 30770-30896 Sentence denotes Understanding and controlling the activation of innate antiviral immune responses is an important step toward novel therapies.
T187 30897-31066 Sentence denotes About a fifth of world's population is infected by IAV annually, leading to high morbidity and mortality, particularly in infants, the elderly and the immunocompromised.
T188 31067-31175 Sentence denotes The high mutation rate of IAV turns all attempts of vaccine and antiviral design into a never ending battle.
T189 31176-31315 Sentence denotes In recent years, RNA interference, triggered by synthetic short interfering RNA (siRNA), has rapidly evolved as a potent antiviral regimen.
T190 31316-31421 Sentence denotes Properly designed siRNAs have been shown to function as potent inhibitors of influenza virus replication.
T191 31422-31698 Sentence denotes Although specificity and tissue delivery remain major bottlenecks in the clinical applications of RNAi in general, intranasal application of siRNA against respiratory viruses including, but not limited to influenza virus, has experienced significant success and optimism [83].
T192 31699-31896 Sentence denotes Our results suggest that not only siRNA targeting IAV components, but boosting the antiviral immune response by intranasal administration of siRNA against A20 might be a valid therapeutic approach.
T193 31897-31971 Sentence denotes Also small compound inhibitors of A20 might be an interesting alternative.
T194 31972-32107 Sentence denotes Finally, similar targeting of A20 might be of interest in the battle against other viral infections including RSV and SARS coronavirus.
T195 32109-32130 Sentence denotes Materials and Methods
T196 32132-32148 Sentence denotes Ethics statement
T197 32149-32358 Sentence denotes All experiments on mice were conducted according to the national (Belgian Law 14/08/1986 and 22/12/2003, Belgian Royal Decree 06/04/2010) and European (EU Directives 2010/63/EU, 86/609/EEG) animal regulations.
T198 32359-32482 Sentence denotes Animal protocols were approved by the ethics committee of Ghent University (permit number LA1400091, approval ID 2010/001).
T199 32483-32540 Sentence denotes All efforts were made to ameliorate suffering of animals.
T200 32541-32660 Sentence denotes Mice were anesthetized by intraperitoneal (i.p.) injection of a mixture of ketamine (12 mg/kg) and xylazine (60 mg/kg).
T201 32662-32666 Sentence denotes Mice
T202 32667-32725 Sentence denotes A20fl/fl mice were generated as previously described [56].
T203 32726-32792 Sentence denotes A20fl/fl mice were crossed with LysM-Cre mice [84] (provided by I.
T204 32793-32940 Sentence denotes Förster, Institute of Genetics, University of Cologne, Germany) to generate A20fl/fl LysMCre transgenes and are described in detail elsewhere [48].
T205 32941-33090 Sentence denotes Mice were housed in individually ventilated cages at the VIB Department of Molecular Biomedical Research in specific pathogen-free animal facilities.
T206 33091-33191 Sentence denotes Influenza infections were performed on age- (between 7 and 9 weeks old) and sex-matched littermates.
T207 33192-33273 Sentence denotes A20fl/fl LysM-Cre animals were backcrossed three times to the C57Bl/6 background.
T208 33274-33396 Sentence denotes A20fl/fl mice expressing or lacking the LysM-Cre transgene were termed A20myel-KO and wild type (A20myel-WT) respectively.
T209 33398-33447 Sentence denotes Viral infection and determination of viral titers
T210 33448-33528 Sentence denotes Mouse adapted IAV X-47 (H3N2; PR8×A/Victoria/3/75) was propagated in MDCK cells.
T211 33529-33702 Sentence denotes For viral inoculation, mice were anesthetized by i.p. injection with ketamine (12 mg/kg) and xylazine (60 mg/kg) and 50 µl X-47 diluted in PBS was administered intranasally.
T212 33703-33791 Sentence denotes For lethal and sublethal infection, mice received respectively 2-LD50 or 0.05-LD50 X-47.
T213 33792-33972 Sentence denotes To determine pulmonary viral titers, median tissue culture infectious dose (TCID50) was measured as follows: lungs were homogenized with a Polytron homogenizer (Kinematica) in PBS.
T214 33973-34163 Sentence denotes Eight-fold serial dilutions of lung homogenates were incubated on MDCK cells for 5 days in DMEM supplemented with trypsin (1 µg/ml), 2 mM L-glutamine, 0.4 mM sodium pyruvate and antibiotics.
T215 34164-34281 Sentence denotes For read-out, 0.5% chicken red blood cells (RBC) were added and end-point dilution of hemagglutination was monitored.
T216 34282-34365 Sentence denotes TCID50 titers were then calculated according to the method of Reed and Muench [85].
T217 34367-34424 Sentence denotes Determination of HAI (hemagglutination inhibition) titers
T218 34425-34652 Sentence denotes To determine the HAI titers in infected mice, sera of these were treated with receptor-destroying enzyme (RDE/Cholera filtrate; Sigma) to remove sialic acids from serum proteins capable of aspecific inhibition of agglutination.
T219 34653-34787 Sentence denotes After incubation overnight at 37°C, the RDE was inactivated by addition of 0.75% sodium citrate in PBS and heating to 56°C for 30 min.
T220 34788-34879 Sentence denotes To remove sialic acid binding proteins, sera were cleared with 1/10 volume 50% chicken RBC.
T221 34880-35036 Sentence denotes Titration was done by incubating a two-fold dilution series of sera with 4 HA units of X-47 virus for 1 hour at room temperature in 96-well U-bottom plates.
T222 35037-35126 Sentence denotes Finally, an equal volume of 0.5% chicken RBC was added and titers were read 30 min later.
T223 35127-35373 Sentence denotes Negative controls included PBS instead of immune serum (agglutination control) or PR8 instead of X-47 virus (control for agglutination effect of sera); as positive control, serum from a mouse infected twice with a sublethal dose of X-47 was used.
T224 35375-35444 Sentence denotes In vivo intracellular GrB and IFNγ staining of activated CD8+ T cells
T225 35445-35605 Sentence denotes Granzyme B (GrB) and IFNγ expressing CD8+ T cells were determined by treating the mice intranasally with 50 µg Brefeldin A (Sigma) as previously described [86].
T226 35606-35740 Sentence denotes 6 h later, BAL and lungs were isolated and single cell suspensions were prepared from the lung in the presence of 3 µg/ml Brefeldin A.
T227 35741-35865 Sentence denotes Cells were stained, fixed and permeabilized (Cytofix/Cytoperm, BD Biosciences) according to the manufacturer's instructions.
T228 35866-35962 Sentence denotes Activated CD8+ T cells were analyzed by flow cytometry based on CD62lo CD3+ and CD8+ expression.
T229 35963-36071 Sentence denotes Live/Dead fixable aqua dead cell stain kit (Molecular Probes) was used to discriminate live from dead cells.
T230 36073-36095 Sentence denotes Cells and transfection
T231 36096-36230 Sentence denotes HEK293T and MDCK cells were grown in DMEM (Gibco) supplemented with 10% FCS, 2 mM L-glutamine, 0.4 mM sodium pyruvate and antibiotics.
T232 36231-36451 Sentence denotes HEK293T cells were transfected using the calcium phosphate precipitate transfection method with specific expression vectors (pCAGGS-E-hA20 (LMBP 3778), pCAGGS-E-RIG-I-CARD (LMBP 6517), pEF-HA-IRF-7 (kindly provided by T.
T233 36452-36668 Sentence denotes Taniguchi, Graduate School of Medicine and Faculty of Medicine, University of Tokyo)), NF-κB, IRF3, IRF7 reporter plasmids (respectively pConLuc (LMBP3248), pISRE-luc (LMBP4011), pGL3-IFNα4-luc (kindly provided by J.
T234 36669-36793 Sentence denotes Hiscott, McGill University, Montreal, Quebec, Canada), and pACTbetagal (LMBP4341) for transfection efficiency normalization.
T235 36794-36928 Sentence denotes Details of plasmids are presented along with detailed sequence maps at the BCCM-LMBP plasmid databank http://bccm.belspo.be/index.php.
T236 36929-37129 Sentence denotes For the generation of BMDM, bone marrow cells were cultured 7 days in RPMI 1640 (Gibco) supplemented with 10% FCS, 2 mM L-glutamine, 0.4 mM sodium pyruvate, antibiotics and 40 ng/ml recombinant M-CSF.
T237 37130-37227 Sentence denotes BMDM were of ≥95% purity as measured by flow cytometry using F4/80 and CD11b specific antibodies.
T238 37228-37361 Sentence denotes For the isolation of alveolar macrophages, the trachea was canulated and the lung was flushed 4 times with HBSS containing 1 mM EDTA.
T239 37362-37501 Sentence denotes Alveolar macrophages were cultured in RPMI 1640 (Gibco) supplemented with 1% FCS, 2 mM L-glutamine, 0.4 mM sodium pyruvate and antibiotics.
T240 37503-37519 Sentence denotes Western blotting
T241 37520-37712 Sentence denotes For total lysates, cells were lysed at 4°C for 15 min in lysis buffer (200 mM NaCl, 1% NP-40, 10 mM Tris-HCl pH 7.5, 5 mM EDTA, 2 mM DTT) supplemented with protease and phosphatase inhibitors.
T242 37713-37945 Sentence denotes Nuclear and cytoplasmic lysates were prepared by resuspending cells in B1 (10 mM Hepes pH 7.5, 10 mM KCl, 1 mM MgCl2, 5% glycerol, 0.5 mM EDTA and 0.1 mM EGTA supplemented with protease and phosphatase inhibitors) for 15 min at 4°C.
T243 37946-38058 Sentence denotes Next, NP-40 detergent was added to a final concentration of 0.65% and cells were centrifuged at 500 g for 5 min.
T244 38059-38296 Sentence denotes The nuclear fraction containing pellet was lyzed in B2 (20 mM Hepes pH 7.5, 1% NP-40, 400 mM NaCl, 10 mM KCl, 1 mM MgCl2, 20% glycerol, 0.5 mM EDTA and 0.1 mM EGTA supplemented with protease and phosphatase inhibitors) for 15 min at 4°C.
T245 38297-38429 Sentence denotes The lysates were subsequently separated by SDS-PAGE and analyzed by western blotting and ECL detection (Perkin Elmer Life Sciences).
T246 38430-38638 Sentence denotes Immunoblots were revealed with anti-A20, anti-IκBα, anti-p65, and anti-histon H1 (Santa Cruz), anti-IRF3 (Invitrogen), anti-phospho-IRF3 and anti-phospho-IκBα (Cell Signaling) and anti-actin (MP Biomedicals).
T247 38639-38757 Sentence denotes The density of the bands was quantified (fold induction) with the ImageJ (http://rsbweb.nih.gov/ij) Gel analyzer tool.
T248 38758-38829 Sentence denotes All intensities were calculated relative to the first lane ( = time 0).
T249 38831-38845 Sentence denotes Flow cytometry
T250 38846-38970 Sentence denotes Lungs were dissected and incubated with collagenase type IV (1 mg/ml; Sigma) and DNAse (100 U/ml; Roche) at 37°C for 30 min.
T251 38971-39044 Sentence denotes Subsequently, samples were filtered through a 70 µm and 40 µm nylon mesh.
T252 39045-39158 Sentence denotes For the preparation of BAL, trachea were canulated and airway lumen was flushed 4 times with HBSS with 1 mM EDTA.
T253 39159-39558 Sentence denotes Cells were stained with monoclonal antibodies directed against MHC-II (I-A/I-E) FITC (M5/114.15.2), CD11c PerCP-Cy5.5 (N418), F4/80 APC (BM8), CD62L PE (MEL-14), Granzyme B FITC (NGZB) from eBiosciences and CD3 Molecular Complex Horizon v450 (17A2), Ly6C Horizon v450 (AL-21), Ly6G PE (1A8), CD11b APC-Cy7 (M1/70), CD8α PerCP (53-6.7), IFNγ Alexa 647 (XMG1.2) and CD16/32 (2.4G2) from BD Pharmingen.
T254 39559-39656 Sentence denotes Samples were acquired on a LSRII Cytometer and analyzed using FACSDiva software (BD Biosciences).
T255 39657-39727 Sentence denotes Propidium iodide was used to discriminate between live and dead cells.
T256 39729-39752 Sentence denotes Cytokine quantification
T257 39753-39881 Sentence denotes For TNF ELISA, 96-well plates were coated with TNF coating (TN3-19, eBioscience) and detection (R4-6A2, eBioscience) antibodies.
T258 39882-39975 Sentence denotes IFNα and IFNβ protein levels were determined with an ELISA kit (PBL Biomedical Laboratories).
T259 39976-40095 Sentence denotes For IFNγ ELISA, 96-well plates were coated with IFNγ coating (XMG1.2) and detection (R4-6A2) antibodies (eBiosciences).
T260 40096-40246 Sentence denotes Detection of MCP-1, KC, TNF, IL-1β and IL-6 in BAL fluid was performed using Bioplex (BioRad) technology according to the manufacturer's instructions.
T261 40247-40329 Sentence denotes Milliplex technology (Millipore) was used for the detection of MIP-2 in BAL fluid.
T262 40331-40369 Sentence denotes RNA isolation, cDNA synthesis and qPCR
T263 40370-40698 Sentence denotes Total RNA was extracted using Aurum Total RNA mini kit (BioRad) and reverse transcribed into cDNA with iScript cDNA synthesis kit (BioRad) according to the manufacturer's instructions. qPCR was performed by using SYBR Green I master mix I (Roche) in the Lightcycler 480 detection system (Roche) with the following primers: HPRT:
T264 40699-40764 Sentence denotes 5′-AGTGTTGGATACAGGCCAGAC-3′ and 5′CGTGATTCAAATCCCTGAAGT-3′; IL-6:
T265 40765-40836 Sentence denotes 5′-GAGGATACCACTCCCAACAGACC-3′ and 5′-AAGTGCATCATCGTTGTTCATACA-3′; IFNβ:
T266 40837-40904 Sentence denotes 5′-TCAGAATGAGTGGTGGTTGC-3′ and 5′-GACCTTTCAAATGCAGTAGATTCA-3′; A20:
T267 40905-40971 Sentence denotes 5′-AAACCAATGGTGATGGAAACTG-3′ and 5′-GTTGTCCCATTCGTCATTCC-3′; CCL2:
T268 40972-41043 Sentence denotes 5′-TTAAAAACCTGGATCGGAACCAA-3′ and 5′-GCATTAGCTTCAGATTTACGGGT-3′; CXCL1:
T269 41044-41112 Sentence denotes 5′-GAGCCTCTAACCAGTTCCAG-3′ and 5′-TGAGTGTGGCTATGACTTCG-3′ and IFNα4:
T270 41113-41175 Sentence denotes 5′-TGATGAGCTACTACTGGTCAGC-3′ and 5′-GATCTCTTAGCACAAGGATGGC-3′.
T271 41176-41250 Sentence denotes Primers were designed with PerlPrimer (http://perlprimer.sourceforge.net).
T272 41251-41319 Sentence denotes Quantification was performed using the comparative CT method (ΔΔCT).
T273 41320-41366 Sentence denotes Results are expressed relative to HPRT values.
T274 41368-41378 Sentence denotes Statistics
T275 41379-41419 Sentence denotes Results are expressed as the mean ± SEM.
T276 41420-41493 Sentence denotes Statistical significance between groups was assessed using two-way ANOVA.
T277 41494-41626 Sentence denotes The differences for in vivo experiments (at least 5 mice per group) were calculated using the Mann-Whitney U-test for unpaired data.
T278 41627-41812 Sentence denotes Statistical significance of differences between survival rates was analyzed by comparing Kaplan-Meier curves using the log-rank test (GraphPad Prism version 5, GraphPad, San Diego, CA).
T279 41814-41836 Sentence denotes Supporting Information
T280 41837-41920 Sentence denotes Figure S1 A20 deficient alveolar macrophages are hyperresponsive to IAV infection.
T281 41921-42059 Sentence denotes Alveolar macrophages isolated from A20myel-KO and wild type (A20myel-WT) mice were mock treated or infected with IAV (moi 1) for 18 hours.
T282 42060-42143 Sentence denotes TNF, MCP-1 (ccl2), KC (cxcl1) and IFNα4 mRNA expression was determined by qPCR (A).
T283 42144-42262 Sentence denotes Cell culture supernatant was analyzed for TNF, MCP-1 and KC protein levels by ELISA and multiplexing technologies (B).
T284 42263-42321 Sentence denotes Error bars represent mean values (+/− SEM) of 2–3 samples.
T285 42322-42410 Sentence denotes Results are representative for 2 independent experiments. *p<0.05; **p<0.01; ***p<0.001.
T286 42411-42416 Sentence denotes (TIF)
T287 42417-42453 Sentence denotes Click here for additional data file.
T288 42454-42571 Sentence denotes Figure S2 Adaptive immunity is not altered by the absence of A20 in myeloid cells following sublethal IAV infection.
T289 42572-42671 Sentence denotes Wild type (A20myel-WT) and A20myel-KO mice were infected intranasally with a sublethal dose of IAV.
T290 42672-42856 Sentence denotes BAL was isolated from IAV infected mice at 4, 7 and 10 days p.i. and analyzed for total CD8+ T cells, Granzyme B (GrB) and IFNγ expressing CD8+ T cells (A) and IFNγ protein levels (B).
T291 42857-42980 Sentence denotes Total CD8+ T cells, GrB and IFNγ expressing CD8+ T cells in the lung parenchyma were also determined by flow cytometry (C).
T292 42981-43108 Sentence denotes Virus specific antibody titers in serum at 4, 7 and 10 days p.i. were determined via a hemagglutination inhibition (HAI) assay.
T293 43109-43170 Sentence denotes The dashed line depicts the detection limit of the assay (D).
T294 43171-43281 Sentence denotes Numbers are averages +/− SEM of at least 5 mice per group and are representative of 2 independent experiments.
T295 43282-43287 Sentence denotes (TIF)
T296 43288-43324 Sentence denotes Click here for additional data file.
T297 43325-43439 Sentence denotes Figure S3 Adaptive immunity is not altered by the absence of A20 in myeloid cells following lethal IAV infection.
T298 43440-43536 Sentence denotes Wild type (A20myel-WT) and A20myel-KO mice were infected intranasally with a lethal dose of IAV.
T299 43537-43756 Sentence denotes 6 days p.i. mice were sacrificed and analyzed. (A) TNF and IL-1β protein levels in BAL fluid were measured by ELISA and multiplexing technologies. (B) Viral titers in the lung were measured and expressed as mean TCID50.
T300 43757-44172 Sentence denotes The dashed line represents the detection limit. (C) Total CD8+, GrB and IFNγ expressing T cells in BAL fluid were measured using flow cytometry. (D) IFNγ protein levels in BAL fluid were measured by ELISA. (E) Total CD8+, GrB and IFNγ expressing T cells in lung parenchyma were measured using flow cytometry. (F) Virus specific antibody titers in serum were determined via a hemagglutination inhibition (HAI) assay.
T301 44173-44217 Sentence denotes The dashed line depicts the detection limit.
T302 44218-44295 Sentence denotes Numbers are averages +/− SEM of at least 5 mice per group. *p<0.05; **p<0.01.
T303 44296-44301 Sentence denotes (TIF)
T304 44302-44338 Sentence denotes Click here for additional data file.

ICD10

Id Subject Object Predicate Lexical cue
T15291 33398-33413 http://purl.bioontology.org/ontology/ICD10/B34.9 denotes Viral infection
T11908 32049-32071 http://purl.bioontology.org/ontology/ICD10/B34.8 denotes other viral infections
T11907 31454-31462 http://purl.bioontology.org/ontology/ICD10/O80-O84.9 denotes delivery
T11906 32055-32071 http://purl.bioontology.org/ontology/ICD10/B34.9 denotes viral infections
T11905 27035-27050 http://purl.bioontology.org/ontology/ICD10/B34.9 denotes viral infection
T7785 15532-15547 http://purl.bioontology.org/ontology/ICD10/B34.9 denotes viral infection
T1166 8604-8619 http://purl.bioontology.org/ontology/ICD10/B34.9 denotes viral infection
T1165 7702-7710 http://purl.bioontology.org/ontology/ICD10/R64 denotes cachexia

simple1

Id Subject Object Predicate Lexical cue
T65 5-12 Protein denotes Tnfaip3
T20323 16518-16522 Protein denotes IFNβ
T20322 16509-16513 Protein denotes IL-6
T20321 16418-16422 Protein denotes IFNβ
T20320 16409-16413 Protein denotes IL-6
T20319 16257-16261 Protein denotes IFNβ
T20318 16249-16252 Protein denotes TNF
T20317 16128-16132 Protein denotes IFNβ
T20316 16122-16126 Protein denotes IL-6
T19462 12335-12339 Protein denotes IFNβ
T19461 12327-12330 Protein denotes TNF
T19460 12310-12314 Protein denotes IL-6
T19459 12229-12233 Protein denotes IFNβ
T19458 12221-12224 Protein denotes TNF
T19457 12215-12219 Protein denotes IL-6
T19456 12116-12120 Protein denotes IRF3
T19455 12108-12111 Protein denotes p65
T19454 11988-11992 Protein denotes IRF3
T19453 11979-11982 Protein denotes p65
T19452 11748-11752 Protein denotes IRF3
T19451 11706-11710 Protein denotes IκBα
T19450 11372-11376 Protein denotes IRF7
T19449 11285-11295 Protein denotes luciferase
T19448 11270-11274 Protein denotes IRF7
T19447 11253-11257 Protein denotes IRF3
T19446 11180-11185 Protein denotes RIG-I
T19445 11149-11153 Protein denotes IRF3
T16566 36552-36556 Protein denotes IRF7
T16565 36546-36550 Protein denotes IRF3
T11998 30465-30470 Protein denotes RIG-I
T11997 30172-30177 Protein denotes IRF-3
T11996 30143-30148 Protein denotes RIG-I
T11995 30055-30059 Protein denotes CYLD
T11994 29853-29857 Protein denotes IRF3
T11993 29643-29647 Protein denotes IKKε
T11992 29634-29638 Protein denotes TBK1
T11991 29527-29532 Protein denotes RIG-I
T11990 29449-29453 Protein denotes IRF3
T11989 29413-29417 Protein denotes IKKε
T11988 29404-29408 Protein denotes TBK1
T11987 29300-29305 Protein denotes ABIN1
T11986 29089-29093 Protein denotes IRF3
T11985 28836-28840 Protein denotes IRF3
T11984 28795-28799 Protein denotes IFNβ
T11983 28784-28789 Protein denotes MIP-2
T11982 28780-28782 Protein denotes KC
T11981 28774-28778 Protein denotes IL-6
T11980 28769-28772 Protein denotes TNF
T11979 28647-28652 Protein denotes RIG-I
T11978 28448-28453 Protein denotes RIG-I
T11977 28392-28397 Protein denotes RIG-I
T11976 28361-28365 Protein denotes IRF3
T11975 27331-27336 Protein denotes MCP-1
T11974 27169-27174 Protein denotes MCP-1
T11973 26750-26755 Protein denotes IL-1β
T11972 26742-26745 Protein denotes TNF
T11971 26736-26740 Protein denotes IL-6
T11970 26684-26689 Protein denotes MIP-2
T11969 26677-26679 Protein denotes KC
T8925 24148-24153 Protein denotes MCP-1
T8924 23964-23969 Protein denotes IL-1β
T8923 23956-23959 Protein denotes TNF
T8922 23950-23954 Protein denotes IL-6
T8921 23683-23688 Protein denotes MIP-2
T8920 23676-23678 Protein denotes KC
T8919 21991-21994 Protein denotes GrB
T8918 21675-21678 Protein denotes GrB
T8917 21663-21673 Protein denotes Granzyme B
T8916 21267-21272 Protein denotes F4/80
T8915 21168-21173 Protein denotes MCP-1
T8914 20759-20764 Protein denotes F4/80
T8913 20680-20685 Protein denotes MIP-2
T8912 20673-20675 Protein denotes KC
T8911 20507-20512 Protein denotes MCP-1
T8910 20457-20462 Protein denotes MIP-2
T8909 20427-20431 Protein denotes IL-8
T8908 20396-20398 Protein denotes KC
T8907 20323-20328 Protein denotes MCP-1
T8906 20069-20073 Protein denotes IL-6
T8905 20040-20045 Protein denotes MIP-2
T8904 20033-20035 Protein denotes KC
T7809 17606-17610 Protein denotes IRF3
T7808 17582-17587 Protein denotes RIG-I
T7807 17245-17250 Protein denotes cxcl1
T7806 17241-17243 Protein denotes KC
T7805 17231-17235 Protein denotes ccl2
T7804 17224-17229 Protein denotes MCP-1
T7803 17199-17204 Protein denotes IFNα4
T7802 17190-17194 Protein denotes IFNβ
T7801 17170-17173 Protein denotes TNF
T7800 17161-17165 Protein denotes IL-6
T7799 15814-15818 Protein denotes IFNβ
T7798 15806-15809 Protein denotes TNF
T7797 15627-15631 Protein denotes IFNβ
T7796 15618-15622 Protein denotes IL-6
T5082 15168-15172 Protein denotes IRF3
T5081 15144-15149 Protein denotes RIG-I
T5080 14950-14954 Protein denotes IFNβ
T5079 14942-14945 Protein denotes TNF
T5078 14936-14940 Protein denotes IL-6
T5077 14865-14869 Protein denotes IRF3
T5076 14809-14813 Protein denotes IFNβ
T5075 14778-14782 Protein denotes IRF3
T5074 14759-14762 Protein denotes TNF
T5073 14750-14754 Protein denotes IL-6
T5072 14582-14586 Protein denotes IRF3
T5071 14577-14580 Protein denotes p65
T5070 14450-14454 Protein denotes IRF3
T5069 14275-14279 Protein denotes IKKε
T5068 14266-14270 Protein denotes TBK1
T5067 14142-14146 Protein denotes IRF3
T5066 13986-13989 Protein denotes p65
T5065 13926-13930 Protein denotes IκBα
T5064 13416-13420 Protein denotes IRF3
T5063 13391-13395 Protein denotes TLR3
T5062 13306-13310 Protein denotes MDA5
T5061 13288-13293 Protein denotes RIG-I
T5060 13100-13105 Protein denotes RIG-I
T5059 12505-12510 Protein denotes RIG-I
T5058 11068-11069 Protein denotes 7
T5057 11063-11067 Protein denotes IRF3
T5056 11039-11044 Protein denotes RIG-I
T5055 10939-10943 Protein denotes IRF7
T5054 10925-10930 Protein denotes RIG-I
T5053 10889-10893 Protein denotes IRF3
T5052 10837-10841 Protein denotes IRF7
T5051 10661-10665 Protein denotes IRF7
T5050 10587-10597 Protein denotes luciferase
T5049 10567-10571 Protein denotes IRF7
T5048 10485-10489 Protein denotes IRF7
T5047 10423-10427 Protein denotes IRF7
T5046 10361-10365 Protein denotes IRF3
T5045 10298-10302 Protein denotes IRF7
T5044 10239-10243 Protein denotes IRF7
T5043 10233-10237 Protein denotes IRF3
T5042 10209-10213 Protein denotes IRF7
T5041 10104-10109 Protein denotes RIG-I
T5040 10035-10040 Protein denotes RIG-I
T5039 9997-10031 Protein denotes truncated constitutive active form
T5038 9932-9942 Protein denotes luciferase
T5037 9917-9921 Protein denotes IRF3
T5036 9808-9813 Protein denotes RIG-I
T5035 9787-9791 Protein denotes IRF3
T5034 9554-9558 Protein denotes IRF7
T5033 9545-9549 Protein denotes IRF3
T5032 9496-9501 Protein denotes RIG-I
T5031 9480-9484 Protein denotes IRF3
T5030 9456-9461 Protein denotes RIG-I
T1338 8527-8532 Protein denotes IRF-3
T1337 8491-8495 Protein denotes TLR3
T1336 8480-8485 Protein denotes RIG-I
T1335 7531-7536 Protein denotes IL-1R
T1334 7516-7520 Protein denotes TLR4
T1333 7490-7504 Protein denotes TNF receptor I
T1332 7062-7067 Protein denotes RBCK1
T1331 7046-7052 Protein denotes TRIM21
T1330 7035-7039 Protein denotes RAUL
T1329 6993-6997 Protein denotes IRF7
T1328 6984-6988 Protein denotes IRF3
T1327 6822-6827 Protein denotes TRAF3
T1326 6813-6817 Protein denotes MAVS
T1325 6782-6789 Protein denotes TRIAD3A
T1324 6768-6772 Protein denotes AIP4
T1323 6602-6605 Protein denotes RLR
T1322 6530-6534 Protein denotes CYLD
T1321 6519-6523 Protein denotes DUBA
T1320 6440-6445 Protein denotes RIG-I
T1319 6419-6423 Protein denotes IRF3
T1318 6377-6382 Protein denotes TRAF3
T1317 6356-6361 Protein denotes TRAF6
T1316 6280-6285 Protein denotes RIG-I
T1315 6225-6231 Protein denotes Riplet
T1314 6209-6215 Protein denotes TRIM25
T1313 6122-6127 Protein denotes RIG-I
T1312 6011-6015 Protein denotes MAVS
T1311 5828-5834 Protein denotes Cardif
T1310 5822-5826 Protein denotes VISA
T1309 5815-5820 Protein denotes IPS-1
T1308 5797-5801 Protein denotes MAVS
T1307 5753-5758 Protein denotes RIG-I
T1306 5581-5586 Protein denotes RIG-I
T1305 5330-5334 Protein denotes TLR3
T1304 5259-5264 Protein denotes RIG-I
T1303 5213-5218 Protein denotes RIG-I
T1302 5003-5008 Protein denotes RIG-I
T1301 4994-4998 Protein denotes TLR3
T1300 4054-4059 Protein denotes IFI16
T1299 4031-4035 Protein denotes AIM2
T1298 3982-3985 Protein denotes DAI
T1297 3976-3980 Protein denotes TLR9
T1296 3880-3884 Protein denotes MDA5
T1295 3873-3878 Protein denotes RIG-I
T1294 3867-3871 Protein denotes TLR3
T1293 3837-3841 Protein denotes Nod2
T1292 3831-3835 Protein denotes TLR8
T1291 3825-3829 Protein denotes TLR7
T1290 3461-3465 Protein denotes IRF7
T1289 3452-3456 Protein denotes IRF3
T1288 3329-3334 Protein denotes IFN-β
T1287 3318-3323 Protein denotes IFN-α
T1286 3304-3316 Protein denotes interferon-α
T1285 3274-3278 Protein denotes IL-1
T1284 3265-3269 Protein denotes IL-6
T1283 3260-3263 Protein denotes TNF
T68 992-996 Protein denotes IRF3
T67 463-468 Protein denotes RIG-I
T66 433-462 Protein denotes pathogen recognition receptor
T21245 25084-25088 Protein denotes IFNα
T21244 25075-25079 Protein denotes IL-6
T21243 25068-25073 Protein denotes MCP-1
T21242 25061-25066 Protein denotes MIP-2
T21241 25057-25059 Protein denotes KC
T20804 19427-19431 Protein denotes IL-6
T20803 19420-19425 Protein denotes MCP-1
T20802 19413-19418 Protein denotes MIP-2
T20801 19409-19411 Protein denotes KC
T18304 40135-40139 Protein denotes IL-6
T18303 40125-40130 Protein denotes IL-1β
T18302 40120-40123 Protein denotes TNF
T18301 40116-40118 Protein denotes KC
T18300 40109-40114 Protein denotes MCP-1
T18299 39891-39895 Protein denotes IFNβ
T18298 39800-39803 Protein denotes TNF
T18297 39757-39760 Protein denotes TNF
T18694 41106-41111 Protein denotes IFNα4
T18693 41037-41042 Protein denotes CXCL1
T18692 40966-40970 Protein denotes CCL2
T18691 40900-40903 Protein denotes A20
T18690 40831-40835 Protein denotes IFNβ
T18689 40759-40763 Protein denotes IL-6
T17869 39523-39527 Protein denotes CD16
T17868 39495-39499 Protein denotes IFNγ
T17867 39474-39478 Protein denotes CD8α
T17866 39436-39440 Protein denotes Ly6G
T17865 39366-39369 Protein denotes CD3
T17864 39321-39331 Protein denotes Granzyme B
T17863 39302-39307 Protein denotes CD62L
T17862 38886-38905 Protein denotes collagenase type IV
T16145 35946-35949 Protein denotes CD8
T16144 35937-35940 Protein denotes CD3
T16143 35876-35879 Protein denotes CD8
T16142 35482-35485 Protein denotes CD8
T16141 35457-35460 Protein denotes GrB
T16140 35445-35455 Protein denotes Granzyme B
T16139 35432-35435 Protein denotes CD8
T16138 35397-35400 Protein denotes GrB

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T21174 19427-19431 Protein denotes IL-6
T21600 25084-25088 Protein denotes IFNα
T21599 25075-25079 Protein denotes IL-6
T21598 25068-25073 Protein denotes MCP-1
T21597 25061-25066 Protein denotes MIP-2
T21596 25057-25059 Protein denotes KC
T21173 19420-19425 Protein denotes MCP-1
T21172 19413-19418 Protein denotes MIP-2
T21171 19409-19411 Protein denotes KC
T20185 11955-11968 Localization denotes translocation
T20184 11753-11768 Phosphorylation denotes phosphorylation
T20183 11731-11742 Protein_catabolism denotes degradation
T20182 11711-11726 Phosphorylation denotes phosphorylation
T20181 11346-11356 Gene_expression denotes expressing
T20180 11154-11164 Positive_regulation denotes activation
T20179 11130-11138 Negative_regulation denotes inhibits
T20178 12335-12339 Protein denotes IFNβ
T20177 12327-12330 Protein denotes TNF
T20176 12310-12314 Protein denotes IL-6
T20175 12229-12233 Protein denotes IFNβ
T20174 12221-12224 Protein denotes TNF
T20173 12215-12219 Protein denotes IL-6
T20172 12116-12120 Protein denotes IRF3
T20171 12108-12111 Protein denotes p65
T20170 11979-11982 Protein denotes p65
T20169 11988-11992 Protein denotes IRF3
T20168 11748-11752 Protein denotes IRF3
T20167 11706-11710 Protein denotes IκBα
T20166 11372-11376 Protein denotes IRF7
T20165 11285-11295 Protein denotes luciferase
T20164 11270-11274 Protein denotes IRF7
T20163 11253-11257 Protein denotes IRF3
T20162 11180-11185 Protein denotes RIG-I
T20161 11149-11153 Protein denotes IRF3
T20725 16428-16438 Transcription denotes expression
T20724 16146-16156 Transcription denotes expression
T20723 16518-16522 Protein denotes IFNβ
T20722 16509-16513 Protein denotes IL-6
T20721 16418-16422 Protein denotes IFNβ
T20720 16409-16413 Protein denotes IL-6
T20719 16257-16261 Protein denotes IFNβ
T20718 16249-16252 Protein denotes TNF
T20717 16128-16132 Protein denotes IFNβ
T20716 16122-16126 Protein denotes IL-6
T18602 40135-40139 Protein denotes IL-6
T18601 40125-40130 Protein denotes IL-1β
T18600 40120-40123 Protein denotes TNF
T18599 40116-40118 Protein denotes KC
T18598 40109-40114 Protein denotes MCP-1
T18597 39891-39895 Protein denotes IFNβ
T18596 39800-39803 Protein denotes TNF
T18595 39757-39760 Protein denotes TNF
T19074 41106-41111 Protein denotes IFNα4
T19073 41037-41042 Protein denotes CXCL1
T19072 40966-40970 Protein denotes CCL2
T19071 40900-40903 Protein denotes A20
T19070 40831-40835 Protein denotes IFNβ
T19069 40759-40763 Protein denotes IL-6
T18199 39523-39527 Protein denotes CD16
T18198 39495-39499 Protein denotes IFNγ
T18197 39474-39478 Protein denotes CD8α
T18196 39436-39440 Protein denotes Ly6G
T18195 39366-39369 Protein denotes CD3
T18194 39321-39331 Protein denotes Granzyme B
T18193 39302-39307 Protein denotes CD62L
T18192 38886-38905 Protein denotes collagenase type IV
T17134 36336-36346 Gene_expression denotes expression
T17133 36552-36556 Protein denotes IRF7
T17132 36546-36550 Protein denotes IRF3
T16502 35951-35961 Gene_expression denotes expression
T16501 35471-35481 Gene_expression denotes expressing
T16500 35946-35949 Protein denotes CD8
T16499 35937-35940 Protein denotes CD3
T16498 35876-35879 Protein denotes CD8
T16497 35482-35485 Protein denotes CD8
T16496 35457-35460 Protein denotes GrB
T16495 35445-35455 Protein denotes Granzyme B
T16494 35432-35435 Protein denotes CD8
T16493 35397-35400 Protein denotes GrB
T14596 29835-29842 Positive_regulation denotes mediate
T14595 29858-29868 Positive_regulation denotes activation
T14594 29616-29630 Binding denotes ubiquitination
T14593 29513-29523 Regulation denotes regulation
T14592 28841-28851 Positive_regulation denotes activation
T14591 28366-28376 Positive_regulation denotes activation
T14590 28342-28350 Positive_regulation denotes enhanced
T14589 27337-27347 Gene_expression denotes production
T14588 27191-27199 Regulation denotes affected
T14587 26597-26605 Positive_regulation denotes resulted
T14586 26616-26622 Positive_regulation denotes levels
T14585 30465-30470 Protein denotes RIG-I
T14584 30172-30177 Protein denotes IRF-3
T14583 30143-30148 Protein denotes RIG-I
T14582 30055-30059 Protein denotes CYLD
T14581 29853-29857 Protein denotes IRF3
T14580 29643-29647 Protein denotes IKKε
T14579 29634-29638 Protein denotes TBK1
T14578 29527-29532 Protein denotes RIG-I
T14577 29449-29453 Protein denotes IRF3
T14576 29413-29417 Protein denotes IKKε
T14575 29404-29408 Protein denotes TBK1
T14574 29300-29305 Protein denotes ABIN1
T14573 29089-29093 Protein denotes IRF3
T14572 28836-28840 Protein denotes IRF3
T14571 28795-28799 Protein denotes IFNβ
T14570 28784-28789 Protein denotes MIP-2
T14569 28780-28782 Protein denotes KC
T14568 28774-28778 Protein denotes IL-6
T14567 28769-28772 Protein denotes TNF
T14566 28647-28652 Protein denotes RIG-I
T14565 28448-28453 Protein denotes RIG-I
T14564 28392-28397 Protein denotes RIG-I
T14563 28361-28365 Protein denotes IRF3
T14562 27331-27336 Protein denotes MCP-1
T14561 27169-27174 Protein denotes MCP-1
T14560 26750-26755 Protein denotes IL-1β
T14559 26742-26745 Protein denotes TNF
T14558 26736-26740 Protein denotes IL-6
T14557 26684-26689 Protein denotes MIP-2
T14556 26677-26679 Protein denotes KC
T11388 24173-24182 Positive_regulation denotes increased
T11387 24154-24164 Gene_expression denotes production
T11386 24043-24052 Positive_regulation denotes increased
T11385 23689-23699 Gene_expression denotes production
T11384 21154-21164 Gene_expression denotes expression
T11383 20777-20786 Binding denotes recruited
T11382 20337-20347 Gene_expression denotes production
T11381 20311-20319 Positive_regulation denotes increase
T11380 20023-20029 Gene_expression denotes Levels
T11379 24148-24153 Protein denotes MCP-1
T11378 23964-23969 Protein denotes IL-1β
T11377 23956-23959 Protein denotes TNF
T11376 23950-23954 Protein denotes IL-6
T11375 23683-23688 Protein denotes MIP-2
T11374 23676-23678 Protein denotes KC
T11373 21991-21994 Protein denotes GrB
T11372 21675-21678 Protein denotes GrB
T11371 21663-21673 Protein denotes Granzyme B
T11370 21267-21272 Protein denotes F4/80
T11369 21168-21173 Protein denotes MCP-1
T11368 20673-20675 Protein denotes KC
T11367 20759-20764 Protein denotes F4/80
T11366 20680-20685 Protein denotes MIP-2
T11365 20507-20512 Protein denotes MCP-1
T11364 20457-20462 Protein denotes MIP-2
T11363 20427-20431 Protein denotes IL-8
T11362 20396-20398 Protein denotes KC
T11361 20323-20328 Protein denotes MCP-1
T11360 20069-20073 Protein denotes IL-6
T11359 20040-20045 Protein denotes MIP-2
T11358 20033-20035 Protein denotes KC
T8509 17588-17595 Positive_regulation denotes induced
T8508 17611-17621 Positive_regulation denotes activation
T8507 17103-17113 Gene_expression denotes Expression
T8506 17118-17127 Localization denotes secretion
T8505 15796-15802 Positive_regulation denotes levels
T8504 15595-15603 Positive_regulation denotes enhanced
T8503 15604-15614 Gene_expression denotes expression
T8502 17606-17610 Protein denotes IRF3
T8501 17582-17587 Protein denotes RIG-I
T8500 17224-17229 Protein denotes MCP-1
T8499 17199-17204 Protein denotes IFNα4
T8498 17190-17194 Protein denotes IFNβ
T8497 17170-17173 Protein denotes TNF
T8496 17161-17165 Protein denotes IL-6
T8495 17245-17250 Protein denotes cxcl1
T8494 17241-17243 Protein denotes KC
T8493 17231-17235 Protein denotes ccl2
T8492 15814-15818 Protein denotes IFNβ
T8491 15806-15809 Protein denotes TNF
T8490 15627-15631 Protein denotes IFNβ
T8489 15618-15622 Protein denotes IL-6
T7390 15130-15140 Regulation denotes regulation
T7389 15150-15157 Positive_regulation denotes induced
T7388 15109-15113 Regulation denotes role
T7387 15173-15183 Positive_regulation denotes activation
T7386 14841-14851 Positive_regulation denotes activation
T7385 14832-14840 Positive_regulation denotes enhanced
T7384 14906-14914 Localization denotes secreted
T7383 14795-14805 Gene_expression denotes expression
T7382 14723-14731 Regulation denotes controls
T7381 14736-14746 Gene_expression denotes expression
T7380 14783-14790 Regulation denotes control
T7379 14595-14608 Localization denotes translocation
T7378 14455-14470 Phosphorylation denotes phosphorylation
T7377 14162-14171 Positive_regulation denotes activated
T7376 14008-14016 Positive_regulation denotes enhanced
T7375 13965-13978 Localization denotes translocation
T7374 13911-13922 Protein_catabolism denotes degradation
T7373 13881-13896 Phosphorylation denotes phosphorylation
T7372 13871-13880 Positive_regulation denotes increased
T7371 13372-13378 Positive_regulation denotes induce
T7370 13421-13431 Positive_regulation denotes activation
T7369 13279-13287 Positive_regulation denotes activate
T7368 13270-13274 Binding denotes bind
T7367 11070-11080 Positive_regulation denotes activation
T7366 11045-11052 Positive_regulation denotes induced
T7365 11031-11038 Negative_regulation denotes inhibit
T7364 10915-10924 Negative_regulation denotes prevented
T7363 10944-10954 Positive_regulation denotes activation
T7362 10869-10875 Regulation denotes effect
T7361 10931-10938 Positive_regulation denotes induced
T7360 10894-10904 Positive_regulation denotes activation
T7359 10666-10679 Gene_expression denotes co-expression
T7358 10650-10657 Negative_regulation denotes absence
T7357 10490-10500 Gene_expression denotes expression
T7356 10428-10438 Positive_regulation denotes activation
T7355 10366-10376 Positive_regulation denotes activation
T7354 10330-10341 Positive_regulation denotes upregulated
T7353 10261-10270 Gene_expression denotes expressed
T7352 10200-10208 Negative_regulation denotes inhibits
T7351 10214-10224 Positive_regulation denotes activation
T7350 9957-9967 Positive_regulation denotes activation
T7349 9979-9991 Gene_expression denotes transfection
T7348 9897-9905 Negative_regulation denotes prevents
T7347 9792-9802 Positive_regulation denotes activation
T7346 9767-9776 Regulation denotes regulates
T7345 9524-9534 Positive_regulation denotes activation
T7344 9485-9495 Positive_regulation denotes activation
T7343 9462-9469 Positive_regulation denotes induced
T7342 9447-9455 Negative_regulation denotes inhibits
T7341 15168-15172 Protein denotes IRF3
T7340 15144-15149 Protein denotes RIG-I
T7339 14950-14954 Protein denotes IFNβ
T7338 14942-14945 Protein denotes TNF
T7337 14936-14940 Protein denotes IL-6
T7336 14865-14869 Protein denotes IRF3
T7335 14809-14813 Protein denotes IFNβ
T7334 14778-14782 Protein denotes IRF3
T7333 14759-14762 Protein denotes TNF
T7332 14750-14754 Protein denotes IL-6
T7331 14582-14586 Protein denotes IRF3
T7330 14577-14580 Protein denotes p65
T7329 14450-14454 Protein denotes IRF3
T7328 14275-14279 Protein denotes IKKε
T7327 14266-14270 Protein denotes TBK1
T7326 14142-14146 Protein denotes IRF3
T7325 13986-13989 Protein denotes p65
T7324 13926-13930 Protein denotes IκBα
T7323 13416-13420 Protein denotes IRF3
T7322 13391-13395 Protein denotes TLR3
T7321 13306-13310 Protein denotes MDA5
T7320 13288-13293 Protein denotes RIG-I
T7319 13100-13105 Protein denotes RIG-I
T7318 12505-12510 Protein denotes RIG-I
T7317 11068-11069 Protein denotes 7
T7316 11063-11067 Protein denotes IRF3
T7315 11039-11044 Protein denotes RIG-I
T7314 10939-10943 Protein denotes IRF7
T7313 10925-10930 Protein denotes RIG-I
T7312 10889-10893 Protein denotes IRF3
T7311 10837-10841 Protein denotes IRF7
T7310 10661-10665 Protein denotes IRF7
T7309 10587-10597 Protein denotes luciferase
T7308 10567-10571 Protein denotes IRF7
T7307 10485-10489 Protein denotes IRF7
T7306 10423-10427 Protein denotes IRF7
T7305 10361-10365 Protein denotes IRF3
T7304 10298-10302 Protein denotes IRF7
T7303 10239-10243 Protein denotes IRF7
T7302 10233-10237 Protein denotes IRF3
T7301 10209-10213 Protein denotes IRF7
T7300 9932-9942 Protein denotes luciferase
T7299 9917-9921 Protein denotes IRF3
T7298 10104-10109 Protein denotes RIG-I
T7297 10035-10040 Protein denotes RIG-I
T7296 9997-10031 Protein denotes truncated constitutive active form
T7295 9808-9813 Protein denotes RIG-I
T7294 9787-9791 Protein denotes IRF3
T7293 9554-9558 Protein denotes IRF7
T7292 9545-9549 Protein denotes IRF3
T7291 9496-9501 Protein denotes RIG-I
T7290 9480-9484 Protein denotes IRF3
T7289 9456-9461 Protein denotes RIG-I
T4160 6929-6939 Binding denotes attachment
T4159 6852-6863 Protein_catabolism denotes degradation
T4158 6424-6434 Positive_regulation denotes activation
T4157 6286-6296 Positive_regulation denotes activation
T4156 6272-6279 Positive_regulation denotes promote
T4155 5872-5884 Localization denotes translocates
T4154 5759-5768 Binding denotes associate
T4153 5265-5274 Negative_regulation denotes deficient
T4152 5335-5344 Negative_regulation denotes deficient
T4151 3197-3204 Positive_regulation denotes induces
T4150 3209-3219 Gene_expression denotes production
T4149 8527-8532 Protein denotes IRF-3
T4148 8491-8495 Protein denotes TLR3
T4147 8480-8485 Protein denotes RIG-I
T4146 7531-7536 Protein denotes IL-1R
T4145 7516-7520 Protein denotes TLR4
T4144 7490-7504 Protein denotes TNF receptor I
T4143 7062-7067 Protein denotes RBCK1
T4142 7046-7052 Protein denotes TRIM21
T4141 7035-7039 Protein denotes RAUL
T4140 6993-6997 Protein denotes IRF7
T4139 6984-6988 Protein denotes IRF3
T4138 6822-6827 Protein denotes TRAF3
T4137 6813-6817 Protein denotes MAVS
T4136 6782-6789 Protein denotes TRIAD3A
T4135 6768-6772 Protein denotes AIP4
T4134 6602-6605 Protein denotes RLR
T4133 6530-6534 Protein denotes CYLD
T4132 6519-6523 Protein denotes DUBA
T4131 6440-6445 Protein denotes RIG-I
T4130 6419-6423 Protein denotes IRF3
T4129 6377-6382 Protein denotes TRAF3
T4128 6356-6361 Protein denotes TRAF6
T4127 6280-6285 Protein denotes RIG-I
T4126 6225-6231 Protein denotes Riplet
T4125 6209-6215 Protein denotes TRIM25
T4124 6122-6127 Protein denotes RIG-I
T4123 6011-6015 Protein denotes MAVS
T4122 5828-5834 Protein denotes Cardif
T4121 5822-5826 Protein denotes VISA
T4120 5815-5820 Protein denotes IPS-1
T4119 5797-5801 Protein denotes MAVS
T4118 5753-5758 Protein denotes RIG-I
T4117 5581-5586 Protein denotes RIG-I
T4116 5330-5334 Protein denotes TLR3
T4115 5259-5264 Protein denotes RIG-I
T4114 5213-5218 Protein denotes RIG-I
T4113 5003-5008 Protein denotes RIG-I
T4112 4994-4998 Protein denotes TLR3
T4111 4054-4059 Protein denotes IFI16
T607 5-12 Protein denotes Tnfaip3
T611 14-24 Negative_regulation denotes Deficiency
T4110 4031-4035 Protein denotes AIM2
T4109 3982-3985 Protein denotes DAI
T4108 3976-3980 Protein denotes TLR9
T4107 3825-3829 Protein denotes TLR7
T4106 3880-3884 Protein denotes MDA5
T4105 3873-3878 Protein denotes RIG-I
T4104 3867-3871 Protein denotes TLR3
T4103 3837-3841 Protein denotes Nod2
T4102 3831-3835 Protein denotes TLR8
T4101 3461-3465 Protein denotes IRF7
T4100 3452-3456 Protein denotes IRF3
T4099 3329-3334 Protein denotes IFN-β
T4098 3318-3323 Protein denotes IFN-α
T4097 3304-3316 Protein denotes interferon-α
T4096 3274-3278 Protein denotes IL-1
T4095 3265-3269 Protein denotes IL-6
T4094 3260-3263 Protein denotes TNF
T608 433-462 Protein denotes pathogen recognition receptor
T609 463-468 Protein denotes RIG-I
T610 992-996 Protein denotes IRF3
T612 405-414 Positive_regulation denotes activates
T613 997-1007 Positive_regulation denotes activation
T614 973-981 Positive_regulation denotes enhanced
R5284 T7337 T7384 themeOf IL-6,secreted
R5285 T7338 T7384 themeOf TNF,secreted
R5288 T7344 T7342 themeOf activation,inhibits
R5289 T7344 T7343 themeOf activation,induced
R5292 T7347 T7346 themeOf activation,regulates
R5310 T7370 T7371 themeOf activation,induce
R5312 T7373 T7372 themeOf phosphorylation,increased
R5315 T7375 T7376 themeOf translocation,enhanced
R5317 T7390 T7388 themeOf regulation,role
R5318 T7381 T7382 themeOf expression,controls
R5319 T7381 T7382 themeOf expression,controls
R5320 T7383 T7380 themeOf expression,control
R5321 T7386 T7385 themeOf activation,enhanced
R5322 T7387 T7390 themeOf activation,regulation
R5323 T7387 T7389 themeOf activation,induced
R505 T607 T611 themeOf Tnfaip3,Deficiency
R506 T608 T612 themeOf pathogen recognition receptor,activates
R507 T609 T612 themeOf RIG-I,activates
R508 T610 T613 themeOf IRF3,activation
R509 T613 T614 themeOf activation,enhanced
R3057 T4115 T4153 themeOf RIG-I,deficient
R3062 T4116 T4152 themeOf TLR3,deficient
R3063 T4118 T4154 themeOf RIG-I,associate
R3070 T4119 T4154 themeOf MAVS,associate
R3072 T4122 T4155 themeOf Cardif,translocates
R3075 T4127 T4157 themeOf RIG-I,activation
R3082 T4130 T4158 themeOf IRF3,activation
R3090 T4150 T4151 themeOf production,induces
R3091 T4150 T4151 themeOf production,induces
R3093 T4150 T4151 themeOf production,induces
R3097 T4157 T4156 themeOf activation,promote
R3039 T4094 T4150 themeOf TNF,production
R3049 T4095 T4150 themeOf IL-6,production
R3053 T4096 T4150 themeOf IL-1,production
R3054 T4097 T4150 themeOf interferon-α,production
R3055 T4098 T4150 themeOf IFN-α,production
R3056 T4099 T4150 themeOf IFN-β,production
R3085 T4137 T4159 themeOf MAVS,degradation
R3086 T4139 T4160 themeOf IRF3,attachment
R3087 T4140 T4160 themeOf IRF7,attachment
R3088 T4142 T4160 themeOf TRIM21,attachment
R3089 T4143 T4160 themeOf RBCK1,attachment
R3094 T4150 T4151 themeOf production,induces
R3095 T4150 T4151 themeOf production,induces
R3096 T4150 T4151 themeOf production,induces
R5237 T7290 T7344 themeOf IRF3,activation
R5239 T7292 T7345 themeOf IRF3,activation
R5240 T7293 T7345 themeOf IRF7,activation
R5241 T7294 T7347 themeOf IRF3,activation
R5264 T7320 T7368 themeOf RIG-I,bind
R5265 T7320 T7369 themeOf RIG-I,activate
R5266 T7321 T7369 themeOf MDA5,activate
R5268 T7323 T7370 themeOf IRF3,activation
R5269 T7324 T7372 themeOf IκBα,increased
R5270 T7324 T7373 themeOf IκBα,phosphorylation
R5271 T7324 T7374 themeOf IκBα,degradation
R5272 T7325 T7375 themeOf p65,translocation
R5274 T7326 T7377 themeOf IRF3,activated
R5276 T7329 T7378 themeOf IRF3,phosphorylation
R5277 T7331 T7379 themeOf IRF3,translocation
R5279 T7332 T7381 themeOf IL-6,expression
R5280 T7333 T7381 themeOf TNF,expression
R5281 T7335 T7383 themeOf IFNβ,expression
R5282 T7336 T7386 themeOf IRF3,activation
R5244 T7296 T7349 themeOf truncated constitutive active form,transfection
R5246 T7300 T7350 themeOf luciferase,activation
R5248 T7301 T7351 themeOf IRF7,activation
R5249 T7302 T7353 themeOf IRF3,expressed
R5250 T7303 T7353 themeOf IRF7,expressed
R5251 T7304 T7354 themeOf IRF7,upregulated
R5252 T7305 T7355 themeOf IRF3,activation
R5254 T7306 T7356 themeOf IRF7,activation
R5255 T7307 T7357 themeOf IRF7,expression
R5256 T7310 T7359 themeOf IRF7,co-expression
R5258 T7312 T7360 themeOf IRF3,activation
R5260 T7314 T7363 themeOf IRF7,activation
R5261 T7316 T7367 themeOf IRF3,activation
R5287 T7341 T7387 themeOf IRF3,activation
R5294 T7350 T7348 themeOf activation,prevents
R5295 T7351 T7352 themeOf activation,inhibits
R5296 T7355 T7354 themeOf activation,upregulated
R5299 T7359 T7358 themeOf co-expression,absence
R5300 T7360 T7362 themeOf activation,effect
R5303 T7363 T7364 themeOf activation,prevented
R5304 T7363 T7361 themeOf activation,induced
R5307 T7367 T7365 themeOf activation,inhibit
R5308 T7367 T7366 themeOf activation,induced
R6052 T8489 T8503 themeOf IL-6,expression
R6053 T8490 T8503 themeOf IFNβ,expression
R6054 T8491 T8505 themeOf TNF,levels
R6057 T8494 T8506 themeOf KC,secretion
R6059 T8495 T8506 themeOf cxcl1,secretion
R6061 T8496 T8506 themeOf IL-6,secretion
R6063 T8497 T8506 themeOf TNF,secretion
R6069 T8500 T8506 themeOf MCP-1,secretion
R6073 T8503 T8504 themeOf expression,enhanced
R6074 T8503 T8504 themeOf expression,enhanced
R6055 T8493 T8506 themeOf ccl2,secretion
R6056 T8493 T8507 themeOf ccl2,Expression
R6058 T8494 T8507 themeOf KC,Expression
R6060 T8495 T8507 themeOf cxcl1,Expression
R6062 T8496 T8507 themeOf IL-6,Expression
R6064 T8497 T8507 themeOf TNF,Expression
R6065 T8498 T8506 themeOf IFNβ,secretion
R6066 T8498 T8507 themeOf IFNβ,Expression
R6067 T8499 T8506 themeOf IFNα4,secretion
R6068 T8499 T8507 themeOf IFNα4,Expression
R6070 T8500 T8507 themeOf MCP-1,Expression
R6071 T8501 T8509 themeOf RIG-I,induced
R6072 T8502 T8508 themeOf IRF3,activation
R8436 T11358 T11380 themeOf KC,Levels
R8438 T11360 T11380 themeOf IL-6,Levels
R8439 T11361 T11381 themeOf MCP-1,increase
R8440 T11361 T11382 themeOf MCP-1,production
R8443 T11367 T11383 themeOf F4/80,recruited
R8444 T11369 T11384 themeOf MCP-1,expression
R8447 T11374 T11385 themeOf KC,production
R8449 T11375 T11385 themeOf MIP-2,production
R8450 T11376 T11386 themeOf IL-6,increased
R8452 T11379 T11387 themeOf MCP-1,production
R8454 T11387 T11388 themeOf production,increased
R10911 T14556 T14587 themeOf KC,resulted
R10913 T14556 T14586 themeOf KC,levels
R10914 T14557 T14586 themeOf MIP-2,levels
R10916 T14561 T14588 themeOf MCP-1,affected
R10917 T14562 T14589 themeOf MCP-1,production
R10918 T14563 T14591 themeOf IRF3,activation
R10919 T14572 T14592 themeOf IRF3,activation
R10920 T14578 T14593 themeOf RIG-I,regulation
R10923 T14579 T14594 themeOf TBK1,ubiquitination
R10925 T14580 T14594 themeOf IKKε,ubiquitination
R10926 T14581 T14595 themeOf IRF3,activation
R10927 T14591 T14590 themeOf activation,enhanced
R10931 T14595 T14596 themeOf activation,mediate
R12418 T16495 T16501 themeOf Granzyme B,expressing
R12419 T16496 T16501 themeOf GrB,expressing
R12420 T16497 T16501 themeOf CD8,expressing
R12421 T16499 T16502 themeOf CD3,expression
R12422 T16500 T16502 themeOf CD8,expression
R12947 T17132 T17134 themeOf IRF3,expression
R15123 T20161 T20180 themeOf IRF3,activation
R15124 T20166 T20181 themeOf IRF7,expressing
R15125 T20167 T20182 themeOf IκBα,phosphorylation
R15126 T20167 T20183 themeOf IκBα,degradation
R15127 T20168 T20184 themeOf IRF3,phosphorylation
R15128 T20169 T20185 themeOf IRF3,translocation
R15129 T20170 T20185 themeOf p65,translocation
R15130 T20180 T20179 themeOf activation,inhibits
R15489 T20716 T20724 themeOf IL-6,expression
R15490 T20717 T20724 themeOf IFNβ,expression
R15491 T20720 T20725 themeOf IL-6,expression
R15492 T20721 T20725 themeOf IFNβ,expression

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T21148 19427-19431 Protein denotes IL-6
T21147 19420-19425 Protein denotes MCP-1
T21146 19413-19418 Protein denotes MIP-2
T21145 19409-19411 Protein denotes KC
T21571 25084-25088 Protein denotes IFNα
T21570 25075-25079 Protein denotes IL-6
T21569 25068-25073 Protein denotes MCP-1
T21568 25061-25066 Protein denotes MIP-2
T21567 25057-25059 Protein denotes KC
T20657 16428-16438 Transcription denotes expression
T20656 16146-16156 Transcription denotes expression
T20655 16518-16522 Protein denotes IFNβ
T20654 16509-16513 Protein denotes IL-6
T20653 16418-16422 Protein denotes IFNβ
T20652 16409-16413 Protein denotes IL-6
T20651 16257-16261 Protein denotes IFNβ
T20650 16249-16252 Protein denotes TNF
T20649 16128-16132 Protein denotes IFNβ
T20648 16122-16126 Protein denotes IL-6
T20021 11955-11968 Localization denotes translocation
T20020 11711-11726 Phosphorylation denotes phosphorylation
T20019 11753-11768 Phosphorylation denotes phosphorylation
T20018 11346-11356 Gene_expression denotes expressing
T20017 11275-11284 Regulation denotes dependent
T20016 11130-11138 Negative_regulation denotes inhibits
T20015 11154-11164 Positive_regulation denotes activation
T20014 11168-11176 Positive_regulation denotes response
T20013 12335-12339 Protein denotes IFNβ
T20012 12327-12330 Protein denotes TNF
T20011 12310-12314 Protein denotes IL-6
T20010 12229-12233 Protein denotes IFNβ
T20009 12221-12224 Protein denotes TNF
T20008 12215-12219 Protein denotes IL-6
T20007 12116-12120 Protein denotes IRF3
T20006 12108-12111 Protein denotes p65
T20005 11979-11982 Protein denotes p65
T20004 11988-11992 Protein denotes IRF3
T20003 11748-11752 Protein denotes IRF3
T20002 11706-11710 Protein denotes IκBα
T20001 11372-11376 Protein denotes IRF7
T20000 11285-11295 Protein denotes luciferase
T19999 11270-11274 Protein denotes IRF7
T19998 11253-11257 Protein denotes IRF3
T19997 11180-11185 Protein denotes RIG-I
T19996 11149-11153 Protein denotes IRF3
T19038 41106-41111 Protein denotes IFNα4
T19037 41037-41042 Protein denotes CXCL1
T19036 40966-40970 Protein denotes CCL2
T19035 40900-40903 Protein denotes A20
T19034 40831-40835 Protein denotes IFNβ
T19033 40759-40763 Protein denotes IL-6
T18548 40135-40139 Protein denotes IL-6
T18547 40125-40130 Protein denotes IL-1β
T18546 40120-40123 Protein denotes TNF
T18545 40116-40118 Protein denotes KC
T18544 40109-40114 Protein denotes MCP-1
T18543 39891-39895 Protein denotes IFNβ
T18542 39800-39803 Protein denotes TNF
T18541 39757-39760 Protein denotes TNF
T18157 39523-39527 Protein denotes CD16
T18156 39495-39499 Protein denotes IFNγ
T18155 39474-39478 Protein denotes CD8α
T18154 39436-39440 Protein denotes Ly6G
T18153 39366-39369 Protein denotes CD3
T18152 39321-39331 Protein denotes Granzyme B
T18151 39302-39307 Protein denotes CD62L
T18150 38886-38905 Protein denotes collagenase type IV
T17083 36552-36556 Protein denotes IRF7
T17082 36546-36550 Protein denotes IRF3
T16434 35951-35961 Gene_expression denotes expression
T16433 35471-35481 Gene_expression denotes expressing
T16432 35946-35949 Protein denotes CD8
T16431 35937-35940 Protein denotes CD3
T16430 35876-35879 Protein denotes CD8
T16429 35482-35485 Protein denotes CD8
T16428 35457-35460 Protein denotes GrB
T16427 35445-35455 Protein denotes Granzyme B
T16426 35432-35435 Protein denotes CD8
T16425 35397-35400 Protein denotes GrB
T14336 29858-29868 Positive_regulation denotes activation
T14335 29835-29842 Positive_regulation denotes mediate
T14334 29616-29630 Binding denotes ubiquitination
T14333 29533-29540 Positive_regulation denotes induced
T14332 29547-29557 Positive_regulation denotes activation
T14331 29513-29523 Regulation denotes regulation
T14330 28342-28350 Positive_regulation denotes enhanced
T14329 28366-28376 Positive_regulation denotes activation
T14328 27191-27199 Regulation denotes affected
T14327 27337-27347 Gene_expression denotes production
T14326 26597-26605 Positive_regulation denotes resulted
T14325 30465-30470 Protein denotes RIG-I
T14323 30143-30148 Protein denotes RIG-I
T14322 30055-30059 Protein denotes CYLD
T14321 29853-29857 Protein denotes IRF3
T14320 29643-29647 Protein denotes IKKε
T14319 29634-29638 Protein denotes TBK1
T14318 29527-29532 Protein denotes RIG-I
T14317 29449-29453 Protein denotes IRF3
T14316 29413-29417 Protein denotes IKKε
T14315 29404-29408 Protein denotes TBK1
T14314 29300-29305 Protein denotes ABIN1
T14313 29089-29093 Protein denotes IRF3
T14312 28836-28840 Protein denotes IRF3
T14311 28795-28799 Protein denotes IFNβ
T14310 28784-28789 Protein denotes MIP-2
T14309 28780-28782 Protein denotes KC
T14308 28774-28778 Protein denotes IL-6
T14307 28769-28772 Protein denotes TNF
T14306 28647-28652 Protein denotes RIG-I
T14305 28448-28453 Protein denotes RIG-I
T14304 28392-28397 Protein denotes RIG-I
T14303 28361-28365 Protein denotes IRF3
T14302 27331-27336 Protein denotes MCP-1
T14301 27169-27174 Protein denotes MCP-1
T14300 26750-26755 Protein denotes IL-1β
T14299 26742-26745 Protein denotes TNF
T14298 26736-26740 Protein denotes IL-6
T14297 26684-26689 Protein denotes MIP-2
T14296 26677-26679 Protein denotes KC
T11173 24154-24164 Gene_expression denotes production
T11172 24173-24182 Positive_regulation denotes increased
T11171 24192-24197 Positive_regulation denotes lower
T11170 24043-24052 Positive_regulation denotes increased
T11169 23689-23699 Gene_expression denotes production
T11168 21154-21164 Gene_expression denotes expression
T11167 20666-20672 Positive_regulation denotes higher
T11166 20311-20319 Positive_regulation denotes increase
T11165 24148-24153 Protein denotes MCP-1
T11164 23964-23969 Protein denotes IL-1β
T11163 23956-23959 Protein denotes TNF
T11162 23950-23954 Protein denotes IL-6
T11161 23683-23688 Protein denotes MIP-2
T11160 23676-23678 Protein denotes KC
T11159 21991-21994 Protein denotes GrB
T11158 21675-21678 Protein denotes GrB
T11157 21663-21673 Protein denotes Granzyme B
T11156 21267-21272 Protein denotes F4/80
T11155 21168-21173 Protein denotes MCP-1
T11154 20673-20675 Protein denotes KC
T11153 20759-20764 Protein denotes F4/80
T11152 20680-20685 Protein denotes MIP-2
T11151 20507-20512 Protein denotes MCP-1
T11150 20457-20462 Protein denotes MIP-2
T11149 20427-20431 Protein denotes IL-8
T11148 20396-20398 Protein denotes KC
T11147 20323-20328 Protein denotes MCP-1
T11146 20069-20073 Protein denotes IL-6
T11145 20040-20045 Protein denotes MIP-2
T11144 20033-20035 Protein denotes KC
T8374 17611-17621 Positive_regulation denotes activation
T8373 17103-17113 Gene_expression denotes Expression
T8372 17118-17127 Gene_expression denotes secretion
T8371 15595-15603 Positive_regulation denotes enhanced
T8370 15604-15614 Gene_expression denotes expression
T8369 17606-17610 Protein denotes IRF3
T8368 17582-17587 Protein denotes RIG-I
T8367 17224-17229 Protein denotes MCP-1
T8366 17199-17204 Protein denotes IFNα4
T8365 17190-17194 Protein denotes IFNβ
T8364 17170-17173 Protein denotes TNF
T8363 17161-17165 Protein denotes IL-6
T8362 17245-17250 Protein denotes cxcl1
T8361 17241-17243 Protein denotes KC
T8360 17231-17235 Protein denotes ccl2
T8359 15814-15818 Protein denotes IFNβ
T8358 15806-15809 Protein denotes TNF
T8357 15627-15631 Protein denotes IFNβ
T8356 15618-15622 Protein denotes IL-6
T6749 9447-9455 Negative_regulation denotes inhibits
T6748 15168-15172 Protein denotes IRF3
T6747 15144-15149 Protein denotes RIG-I
T6707 9932-9942 Protein denotes luciferase
T6706 9917-9921 Protein denotes IRF3
T6705 10104-10109 Protein denotes RIG-I
T6704 10035-10040 Protein denotes RIG-I
T6703 9997-10031 Protein denotes truncated constitutive active form
T6702 9808-9813 Protein denotes RIG-I
T6701 9787-9791 Protein denotes IRF3
T6700 9554-9558 Protein denotes IRF7
T6699 9545-9549 Protein denotes IRF3
T6698 9496-9501 Protein denotes RIG-I
T6697 9480-9484 Protein denotes IRF3
T6696 9456-9461 Protein denotes RIG-I
T6797 15150-15157 Positive_regulation denotes induced
T6796 15130-15140 Regulation denotes regulation
T6795 15173-15183 Positive_regulation denotes activation
T6794 14841-14851 Positive_regulation denotes activation
T6793 14832-14840 Positive_regulation denotes enhanced
T6792 14906-14914 Localization denotes secreted
T6791 14915-14924 Positive_regulation denotes increased
T6790 14795-14805 Gene_expression denotes expression
T6789 14723-14731 Regulation denotes controls
T6788 14736-14746 Gene_expression denotes expression
T3750 6929-6939 Binding denotes attachment
T3749 6852-6863 Protein_catabolism denotes degradation
T3748 6843-6851 Positive_regulation denotes mediated
T3747 6424-6434 Positive_regulation denotes activation
T3746 6272-6279 Positive_regulation denotes promote
T3745 6286-6296 Positive_regulation denotes activation
T3744 5872-5884 Localization denotes translocates
T3743 5759-5768 Binding denotes associate
T3742 5335-5344 Negative_regulation denotes deficient
T3741 5265-5274 Negative_regulation denotes deficient
T3740 3197-3204 Positive_regulation denotes induces
T3739 3209-3219 Gene_expression denotes production
T3738 8527-8532 Protein denotes IRF-3
T3737 8491-8495 Protein denotes TLR3
T3736 8480-8485 Protein denotes RIG-I
T3735 7531-7536 Protein denotes IL-1R
T3734 7516-7520 Protein denotes TLR4
T3733 7490-7504 Protein denotes TNF receptor I
T3732 7062-7067 Protein denotes RBCK1
T3731 7046-7052 Protein denotes TRIM21
T3730 7035-7039 Protein denotes RAUL
T3729 6993-6997 Protein denotes IRF7
T3728 6984-6988 Protein denotes IRF3
T3727 6822-6827 Protein denotes TRAF3
T3726 6813-6817 Protein denotes MAVS
T3725 6782-6789 Protein denotes TRIAD3A
T3724 6768-6772 Protein denotes AIP4
T3723 6602-6605 Protein denotes RLR
T3722 6530-6534 Protein denotes CYLD
T3721 6519-6523 Protein denotes DUBA
T3720 6440-6445 Protein denotes RIG-I
T3719 6419-6423 Protein denotes IRF3
T3718 6377-6382 Protein denotes TRAF3
T3717 6356-6361 Protein denotes TRAF6
T3716 6280-6285 Protein denotes RIG-I
T3715 6225-6231 Protein denotes Riplet
T3714 6209-6215 Protein denotes TRIM25
T3713 6122-6127 Protein denotes RIG-I
T3712 6011-6015 Protein denotes MAVS
T3711 5828-5834 Protein denotes Cardif
T3710 5822-5826 Protein denotes VISA
T3709 5815-5820 Protein denotes IPS-1
T3708 5797-5801 Protein denotes MAVS
T3707 5753-5758 Protein denotes RIG-I
T3706 5581-5586 Protein denotes RIG-I
T3705 5330-5334 Protein denotes TLR3
T3704 5259-5264 Protein denotes RIG-I
T3703 5213-5218 Protein denotes RIG-I
T3702 5003-5008 Protein denotes RIG-I
T3701 4994-4998 Protein denotes TLR3
T3700 4054-4059 Protein denotes IFI16
T3699 4031-4035 Protein denotes AIM2
T3684 3265-3269 Protein denotes IL-6
T548 997-1007 Positive_regulation denotes activation
T542 5-12 Protein denotes Tnfaip3
T3683 3260-3263 Protein denotes TNF
T543 433-462 Protein denotes pathogen recognition receptor
T544 463-468 Protein denotes RIG-I
T545 992-996 Protein denotes IRF3
T547 405-414 Positive_regulation denotes activates
T546 14-24 Negative_regulation denotes Deficiency
T3698 3982-3985 Protein denotes DAI
T3697 3976-3980 Protein denotes TLR9
T3696 3825-3829 Protein denotes TLR7
T3695 3880-3884 Protein denotes MDA5
T3694 3873-3878 Protein denotes RIG-I
T3693 3867-3871 Protein denotes TLR3
T3692 3837-3841 Protein denotes Nod2
T3691 3831-3835 Protein denotes TLR8
T3690 3461-3465 Protein denotes IRF7
T3689 3452-3456 Protein denotes IRF3
T3688 3329-3334 Protein denotes IFN-β
T3687 3318-3323 Protein denotes IFN-α
T3686 3304-3316 Protein denotes interferon-α
T3685 3274-3278 Protein denotes IL-1
T6746 14950-14954 Protein denotes IFNβ
T6745 14942-14945 Protein denotes TNF
T6744 14936-14940 Protein denotes IL-6
T6743 14865-14869 Protein denotes IRF3
T6742 14809-14813 Protein denotes IFNβ
T6741 14778-14782 Protein denotes IRF3
T6740 14759-14762 Protein denotes TNF
T6739 14750-14754 Protein denotes IL-6
T6738 14582-14586 Protein denotes IRF3
T6737 14577-14580 Protein denotes p65
T6736 14450-14454 Protein denotes IRF3
T6735 14275-14279 Protein denotes IKKε
T6734 14266-14270 Protein denotes TBK1
T6733 14142-14146 Protein denotes IRF3
T6732 13986-13989 Protein denotes p65
T6731 13926-13930 Protein denotes IκBα
T6730 13416-13420 Protein denotes IRF3
T6729 13391-13395 Protein denotes TLR3
T6728 13306-13310 Protein denotes MDA5
T6727 13288-13293 Protein denotes RIG-I
T6726 13100-13105 Protein denotes RIG-I
T6725 12505-12510 Protein denotes RIG-I
T6724 11068-11069 Protein denotes 7
T6723 11063-11067 Protein denotes IRF3
T6722 11039-11044 Protein denotes RIG-I
T6721 10939-10943 Protein denotes IRF7
T6720 10925-10930 Protein denotes RIG-I
T6719 10889-10893 Protein denotes IRF3
T6718 10837-10841 Protein denotes IRF7
T6717 10661-10665 Protein denotes IRF7
T6716 10587-10597 Protein denotes luciferase
T6715 10567-10571 Protein denotes IRF7
T6714 10485-10489 Protein denotes IRF7
T6713 10423-10427 Protein denotes IRF7
T6712 10361-10365 Protein denotes IRF3
T6711 10298-10302 Protein denotes IRF7
T6710 10239-10243 Protein denotes IRF7
T6709 10233-10237 Protein denotes IRF3
T6708 10209-10213 Protein denotes IRF7
T6758 9922-9931 Positive_regulation denotes dependent
T6757 9957-9967 Positive_regulation denotes activation
T6756 9968-9975 Positive_regulation denotes induced
T6755 9979-9991 Gene_expression denotes transfection
T6754 9767-9776 Regulation denotes regulates
T6753 9792-9802 Positive_regulation denotes activation
T6752 9524-9534 Positive_regulation denotes activation
T6751 9485-9495 Positive_regulation denotes activation
T6750 9462-9469 Positive_regulation denotes induced
T6768 10650-10657 Negative_regulation denotes absence
T6767 10666-10679 Gene_expression denotes co-expression
T6766 10490-10500 Gene_expression denotes expression
T6765 10406-10412 Regulation denotes effect
T6764 10428-10438 Positive_regulation denotes activation
T6763 10261-10270 Gene_expression denotes expressed
T6762 10366-10376 Positive_regulation denotes activation
T6761 10330-10341 Positive_regulation denotes upregulated
T6760 10214-10224 Positive_regulation denotes activation
T6759 10200-10208 Negative_regulation denotes inhibits
T6787 14595-14608 Localization denotes translocation
T6786 14455-14470 Phosphorylation denotes phosphorylation
T6785 13965-13978 Localization denotes translocation
T6784 14008-14016 Positive_regulation denotes enhanced
T6783 13881-13896 Phosphorylation denotes phosphorylation
T6782 13871-13880 Positive_regulation denotes increased
T6781 13911-13922 Protein_catabolism denotes degradation
T6780 13372-13378 Positive_regulation denotes induce
T6779 13421-13431 Positive_regulation denotes activation
T6778 13270-13274 Binding denotes bind
T6777 13279-13287 Positive_regulation denotes activate
T6776 11031-11038 Negative_regulation denotes inhibit
T6775 11070-11080 Positive_regulation denotes activation
T6774 11045-11052 Positive_regulation denotes induced
T6773 10894-10904 Positive_regulation denotes activation
T6772 10944-10954 Positive_regulation denotes activation
T6771 10915-10924 Negative_regulation denotes prevented
T6770 10869-10875 Regulation denotes effect
T6769 10931-10938 Positive_regulation denotes induced
T14324 30172-30177 Protein denotes IRF-3
R8372 T11173 T11171 themeOf production,lower
R2932 T3683 T3739 themeOf TNF,production
R2933 T3684 T3739 themeOf IL-6,production
R2935 T3687 T3739 themeOf IFN-α,production
R2936 T3688 T3739 themeOf IFN-β,production
R2961 T3726 T3749 themeOf MAVS,degradation
R2966 T3728 T3750 themeOf IRF3,attachment
R2967 T3729 T3750 themeOf IRF7,attachment
R2968 T3730 T3750 themeOf RAUL,attachment
R2969 T3731 T3750 themeOf TRIM21,attachment
R2971 T3732 T3750 themeOf RBCK1,attachment
R2991 T3749 T3748 themeOf degradation,mediated
R4897 T6696 T6750 causeOf RIG-I,induced
R4898 T6697 T6751 themeOf IRF3,activation
R4899 T6699 T6752 themeOf IRF3,activation
R4900 T6700 T6752 themeOf IRF7,activation
R4901 T6701 T6753 themeOf IRF3,activation
R4902 T6703 T6755 themeOf truncated constitutive active form,transfection
R4903 T6751 T6749 themeOf activation,inhibits
R4904 T6706 T6758 causeOf IRF3,dependent
R4905 T6707 T6757 themeOf luciferase,activation
R4906 T6751 T6750 themeOf activation,induced
R4907 T6708 T6760 themeOf IRF7,activation
R4908 T6709 T6763 themeOf IRF3,expressed
R4909 T6753 T6754 themeOf activation,regulates
R4910 T6710 T6763 themeOf IRF7,expressed
R4911 T6711 T6761 themeOf IRF7,upregulated
R4912 T6712 T6762 themeOf IRF3,activation
R4913 T6713 T6764 themeOf IRF7,activation
R4914 T6755 T6756 causeOf transfection,induced
R4915 T6714 T6766 themeOf IRF7,expression
R4916 T6757 T6758 themeOf activation,dependent
R4917 T6717 T6767 themeOf IRF7,co-expression
R4918 T6719 T6773 themeOf IRF3,activation
R4919 T6720 T6769 causeOf RIG-I,induced
R4920 T6721 T6772 themeOf IRF7,activation
R4921 T6757 T6756 themeOf activation,induced
R4922 T6722 T6774 causeOf RIG-I,induced
R4923 T6723 T6775 themeOf IRF3,activation
R4924 T6760 T6759 themeOf activation,inhibits
R4925 T6764 T6765 themeOf activation,effect
R4926 T6727 T6778 themeOf RIG-I,bind
R4927 T6727 T6777 themeOf RIG-I,activate
R4928 T6767 T6768 themeOf co-expression,absence
R4929 T6772 T6771 themeOf activation,prevented
R4930 T6730 T6779 themeOf IRF3,activation
R4931 T6731 T6783 themeOf IκBα,phosphorylation
R4932 T6731 T6781 themeOf IκBα,degradation
R4933 T6732 T6785 themeOf p65,translocation
R4934 T6736 T6786 themeOf IRF3,phosphorylation
R4935 T6772 T6769 themeOf activation,induced
R4936 T6773 T6770 themeOf activation,effect
R4937 T6738 T6787 themeOf IRF3,translocation
R4938 T6739 T6788 themeOf IL-6,expression
R4939 T6740 T6788 themeOf TNF,expression
R4940 T6742 T6790 themeOf IFNβ,expression
R4941 T6775 T6776 themeOf activation,inhibit
R4942 T6743 T6794 themeOf IRF3,activation
R4943 T6744 T6792 themeOf IL-6,secreted
R4944 T6745 T6792 themeOf TNF,secreted
R4945 T6746 T6792 themeOf IFNβ,secreted
R4946 T6747 T6797 causeOf RIG-I,induced
R4947 T6775 T6774 themeOf activation,induced
R4948 T6748 T6795 themeOf IRF3,activation
R4949 T6779 T6780 themeOf activation,induce
R4950 T6783 T6782 themeOf phosphorylation,increased
R4951 T6785 T6784 themeOf translocation,enhanced
R4952 T6788 T6789 themeOf expression,controls
R4953 T6788 T6789 themeOf expression,controls
R4954 T6792 T6791 themeOf secreted,increased
R4955 T6792 T6791 themeOf secreted,increased
R4956 T6792 T6791 themeOf secreted,increased
R4957 T6794 T6793 themeOf activation,enhanced
R4958 T6795 T6796 themeOf activation,regulation
R4959 T6795 T6797 themeOf activation,induced
R5969 T8356 T8370 themeOf IL-6,expression
R5970 T8357 T8370 themeOf IFNβ,expression
R5971 T8360 T8372 themeOf ccl2,secretion
R5972 T8360 T8373 themeOf ccl2,Expression
R5973 T8361 T8372 themeOf KC,secretion
R5974 T8361 T8373 themeOf KC,Expression
R5975 T8362 T8372 themeOf cxcl1,secretion
R5976 T8362 T8373 themeOf cxcl1,Expression
R5977 T8363 T8372 themeOf IL-6,secretion
R5978 T8363 T8373 themeOf IL-6,Expression
R5979 T8364 T8373 themeOf TNF,Expression
R5980 T8366 T8372 themeOf IFNα4,secretion
R5981 T8367 T8372 themeOf MCP-1,secretion
R5982 T8367 T8373 themeOf MCP-1,Expression
R5983 T8369 T8374 themeOf IRF3,activation
R5984 T8370 T8371 themeOf expression,enhanced
R5985 T8370 T8371 themeOf expression,enhanced
R8357 T11147 T11166 themeOf MCP-1,increase
R8360 T11154 T11167 themeOf KC,higher
R8362 T11155 T11168 themeOf MCP-1,expression
R8364 T11160 T11169 themeOf KC,production
R8366 T11161 T11169 themeOf MIP-2,production
R8368 T11164 T11170 themeOf IL-1β,increased
R8369 T11165 T11173 themeOf MCP-1,production
R8371 T11173 T11172 themeOf production,increased
R10786 T14296 T14326 themeOf KC,resulted
R10822 T14301 T14328 themeOf MCP-1,affected
R10826 T14302 T14327 themeOf MCP-1,production
R10827 T14303 T14329 themeOf IRF3,activation
R10828 T14318 T14332 themeOf RIG-I,activation
R10829 T14319 T14334 themeOf TBK1,ubiquitination
R10830 T14329 T14330 themeOf activation,enhanced
R10831 T14320 T14334 themeOf IKKε,ubiquitination
R10832 T14321 T14336 themeOf IRF3,activation
R10833 T14332 T14333 themeOf activation,induced
R10834 T14332 T14331 themeOf activation,regulation
R10835 T14336 T14335 themeOf activation,mediate
R12396 T16427 T16433 themeOf Granzyme B,expressing
R12397 T16428 T16433 themeOf GrB,expressing
R12398 T16431 T16434 themeOf CD3,expression
R15048 T19996 T20015 themeOf IRF3,activation
R15049 T20000 T20017 themeOf luciferase,dependent
R15050 T20001 T20018 themeOf IRF7,expressing
R15051 T20002 T20020 themeOf IκBα,phosphorylation
R15052 T20003 T20019 themeOf IRF3,phosphorylation
R15053 T20004 T20021 themeOf IRF3,translocation
R15054 T20015 T20016 themeOf activation,inhibits
R15055 T20015 T20014 themeOf activation,response
R15471 T20648 T20656 themeOf IL-6,expression
R15472 T20652 T20657 themeOf IL-6,expression
R15473 T20653 T20657 themeOf IFNβ,expression
R497 T542 T546 themeOf Tnfaip3,Deficiency
R498 T544 T547 themeOf RIG-I,activates
R499 T545 T548 themeOf IRF3,activation
R2931 T3685 T3739 themeOf IL-1,production
R2934 T3686 T3739 themeOf interferon-α,production
R2937 T3704 T3741 themeOf RIG-I,deficient
R2944 T3705 T3742 themeOf TLR3,deficient
R2945 T3707 T3743 themeOf RIG-I,associate
R2947 T3711 T3744 themeOf Cardif,translocates
R2952 T3716 T3745 themeOf RIG-I,activation
R2956 T3719 T3747 themeOf IRF3,activation
R2979 T3739 T3740 themeOf production,induces
R2983 T3739 T3740 themeOf production,induces
R2984 T3739 T3740 themeOf production,induces
R2987 T3739 T3740 themeOf production,induces
R2988 T3739 T3740 themeOf production,induces
R2989 T3739 T3740 themeOf production,induces
R2990 T3745 T3746 themeOf activation,promote

DLUT931

Id Subject Object Predicate Lexical cue
T11195 24148-24153 Protein denotes MCP-1
T21152 19427-19431 Protein denotes IL-6
T21151 19420-19425 Protein denotes MCP-1
T21150 19413-19418 Protein denotes MIP-2
T21149 19409-19411 Protein denotes KC
T21576 25084-25088 Protein denotes IFNα
T21575 25075-25079 Protein denotes IL-6
T21574 25068-25073 Protein denotes MCP-1
T21573 25061-25066 Protein denotes MIP-2
T21572 25057-25059 Protein denotes KC
T20070 12145-12154 Gene_expression denotes expressed
T20069 11955-11968 Localization denotes translocation
T20068 11753-11768 Phosphorylation denotes phosphorylation
T20067 11711-11726 Phosphorylation denotes phosphorylation
T20066 11346-11356 Gene_expression denotes expressing
T20065 11275-11284 Regulation denotes dependent
T20064 11130-11138 Negative_regulation denotes inhibits
T20063 11168-11176 Positive_regulation denotes response
T20062 11154-11164 Positive_regulation denotes activation
T20061 12335-12339 Protein denotes IFNβ
T20060 12327-12330 Protein denotes TNF
T20059 12310-12314 Protein denotes IL-6
T20058 12229-12233 Protein denotes IFNβ
T20057 12221-12224 Protein denotes TNF
T20056 12215-12219 Protein denotes IL-6
T20055 12116-12120 Protein denotes IRF3
T20054 12108-12111 Protein denotes p65
T20053 11979-11982 Protein denotes p65
T20052 11988-11992 Protein denotes IRF3
T20051 11748-11752 Protein denotes IRF3
T20050 11706-11710 Protein denotes IκBα
T20677 16428-16438 Transcription denotes expression
T20676 16146-16156 Transcription denotes expression
T20675 16518-16522 Protein denotes IFNβ
T20674 16509-16513 Protein denotes IL-6
T20673 16418-16422 Protein denotes IFNβ
T20672 16409-16413 Protein denotes IL-6
T20671 16257-16261 Protein denotes IFNβ
T20670 16249-16252 Protein denotes TNF
T20669 16128-16132 Protein denotes IFNβ
T20668 16122-16126 Protein denotes IL-6
T20049 11372-11376 Protein denotes IRF7
T20048 11285-11295 Protein denotes luciferase
T20047 11270-11274 Protein denotes IRF7
T20046 11253-11257 Protein denotes IRF3
T20045 11180-11185 Protein denotes RIG-I
T20044 11149-11153 Protein denotes IRF3
T19044 41106-41111 Protein denotes IFNα4
T19043 41037-41042 Protein denotes CXCL1
T19042 40966-40970 Protein denotes CCL2
T19041 40900-40903 Protein denotes A20
T19040 40831-40835 Protein denotes IFNβ
T19039 40759-40763 Protein denotes IL-6
T18556 40135-40139 Protein denotes IL-6
T18555 40125-40130 Protein denotes IL-1β
T18554 40120-40123 Protein denotes TNF
T18553 40116-40118 Protein denotes KC
T18552 40109-40114 Protein denotes MCP-1
T18551 39891-39895 Protein denotes IFNβ
T18550 39800-39803 Protein denotes TNF
T18549 39757-39760 Protein denotes TNF
T18162 39436-39440 Protein denotes Ly6G
T18161 39366-39369 Protein denotes CD3
T18160 39321-39331 Protein denotes Granzyme B
T18159 39302-39307 Protein denotes CD62L
T18158 38886-38905 Protein denotes collagenase type IV
T18165 39523-39527 Protein denotes CD16
T18164 39495-39499 Protein denotes IFNγ
T18163 39474-39478 Protein denotes CD8α
T17088 36336-36346 Gene_expression denotes expression
T17087 36552-36556 Protein denotes IRF7
T17086 36546-36550 Protein denotes IRF3
T16444 35951-35961 Gene_expression denotes expression
T16443 35471-35481 Gene_expression denotes expressing
T16442 35946-35949 Protein denotes CD8
T16441 35937-35940 Protein denotes CD3
T16440 35876-35879 Protein denotes CD8
T16439 35482-35485 Protein denotes CD8
T16438 35457-35460 Protein denotes GrB
T16437 35445-35455 Protein denotes Granzyme B
T16436 35432-35435 Protein denotes CD8
T16435 35397-35400 Protein denotes GrB
T14386 30451-30461 Regulation denotes gatekeeper
T14385 30471-30478 Positive_regulation denotes induced
T14384 29835-29842 Positive_regulation denotes mediate
T14383 29858-29868 Positive_regulation denotes activation
T14382 29616-29630 Ubiquitination denotes ubiquitination
T14381 29497-29505 Regulation denotes involved
T14380 29533-29540 Positive_regulation denotes induced
T14379 29513-29523 Regulation denotes regulation
T14378 29547-29557 Positive_regulation denotes activation
T14377 29368-29377 Positive_regulation denotes affecting
T14376 29378-29400 Positive_regulation denotes K63-polyubiquitination
T14375 29261-29278 Binding denotes ubiquitin-binding
T14374 28815-28825 Regulation denotes regulating
T14373 28638-28646 Positive_regulation denotes enhanced
T14372 28380-28388 Positive_regulation denotes response
T14371 28342-28350 Positive_regulation denotes enhanced
T14370 28398-28409 Positive_regulation denotes stimulation
T14369 28366-28376 Positive_regulation denotes activation
T14368 27337-27347 Gene_expression denotes production
T14367 27191-27199 Regulation denotes affected
T14366 30465-30470 Protein denotes RIG-I
T14365 30172-30177 Protein denotes IRF-3
T14364 30143-30148 Protein denotes RIG-I
T14363 30055-30059 Protein denotes CYLD
T14362 29853-29857 Protein denotes IRF3
T14361 29643-29647 Protein denotes IKKε
T14360 29634-29638 Protein denotes TBK1
T14359 29527-29532 Protein denotes RIG-I
T14358 29449-29453 Protein denotes IRF3
T14357 29413-29417 Protein denotes IKKε
T14356 29404-29408 Protein denotes TBK1
T14355 29300-29305 Protein denotes ABIN1
T14354 29089-29093 Protein denotes IRF3
T14353 28836-28840 Protein denotes IRF3
T14352 28795-28799 Protein denotes IFNβ
T14351 28784-28789 Protein denotes MIP-2
T14350 28780-28782 Protein denotes KC
T14349 28774-28778 Protein denotes IL-6
T14348 28769-28772 Protein denotes TNF
T14347 28647-28652 Protein denotes RIG-I
T14346 28448-28453 Protein denotes RIG-I
T14345 28392-28397 Protein denotes RIG-I
T14344 28361-28365 Protein denotes IRF3
T14343 27331-27336 Protein denotes MCP-1
T14342 27169-27174 Protein denotes MCP-1
T14341 26750-26755 Protein denotes IL-1β
T14340 26742-26745 Protein denotes TNF
T14339 26736-26740 Protein denotes IL-6
T14338 26684-26689 Protein denotes MIP-2
T14337 26677-26679 Protein denotes KC
T11202 24192-24197 Positive_regulation denotes lower
T11201 24173-24182 Positive_regulation denotes increased
T11200 24154-24164 Gene_expression denotes production
T11199 24043-24052 Positive_regulation denotes increased
T11198 23689-23699 Gene_expression denotes production
T11197 21154-21164 Gene_expression denotes expression
T11196 20666-20672 Positive_regulation denotes higher
T11194 23964-23969 Protein denotes IL-1β
T11193 23956-23959 Protein denotes TNF
T11192 23950-23954 Protein denotes IL-6
T11191 23683-23688 Protein denotes MIP-2
T11190 23676-23678 Protein denotes KC
T11189 21991-21994 Protein denotes GrB
T11188 21675-21678 Protein denotes GrB
T11187 21663-21673 Protein denotes Granzyme B
T11186 21267-21272 Protein denotes F4/80
T11185 21168-21173 Protein denotes MCP-1
T11184 20673-20675 Protein denotes KC
T11183 20759-20764 Protein denotes F4/80
T11182 20680-20685 Protein denotes MIP-2
T11181 20507-20512 Protein denotes MCP-1
T11180 20457-20462 Protein denotes MIP-2
T11179 20427-20431 Protein denotes IL-8
T11178 20396-20398 Protein denotes KC
T11177 20323-20328 Protein denotes MCP-1
T11176 20069-20073 Protein denotes IL-6
T11175 20040-20045 Protein denotes MIP-2
T11174 20033-20035 Protein denotes KC
T8394 17611-17621 Positive_regulation denotes activation
T8393 17118-17127 Localization denotes secretion
T8392 17103-17113 Gene_expression denotes Expression
T8391 15789-15795 Positive_regulation denotes higher
T8390 15595-15603 Positive_regulation denotes enhanced
T8389 15604-15614 Gene_expression denotes expression
T8388 17606-17610 Protein denotes IRF3
T8387 17582-17587 Protein denotes RIG-I
T8386 17224-17229 Protein denotes MCP-1
T8385 17199-17204 Protein denotes IFNα4
T8384 17190-17194 Protein denotes IFNβ
T8383 17170-17173 Protein denotes TNF
T8382 17161-17165 Protein denotes IL-6
T8381 17245-17250 Protein denotes cxcl1
T8380 17241-17243 Protein denotes KC
T8379 17231-17235 Protein denotes ccl2
T8378 15814-15818 Protein denotes IFNβ
T8377 15806-15809 Protein denotes TNF
T8376 15627-15631 Protein denotes IFNβ
T8375 15618-15622 Protein denotes IL-6
T6976 15150-15157 Positive_regulation denotes induced
T6975 15130-15140 Regulation denotes regulation
T6974 15173-15183 Positive_regulation denotes activation
T6973 14832-14840 Positive_regulation denotes enhanced
T6972 14915-14924 Positive_regulation denotes increased
T6971 14906-14914 Localization denotes secreted
T6970 14841-14851 Positive_regulation denotes activation
T6969 14723-14731 Regulation denotes controls
T6968 14795-14805 Gene_expression denotes expression
T6967 14736-14746 Gene_expression denotes expression
T6966 14609-14616 Positive_regulation denotes reached
T6965 14595-14608 Localization denotes translocation
T6964 14455-14470 Phosphorylation denotes phosphorylation
T6963 14162-14171 Positive_regulation denotes activated
T6962 14008-14016 Positive_regulation denotes enhanced
T6961 13965-13978 Localization denotes translocation
T6960 13871-13880 Positive_regulation denotes increased
T6959 13911-13922 Protein_catabolism denotes degradation
T6958 13881-13896 Phosphorylation denotes phosphorylation
T6957 13372-13378 Positive_regulation denotes induce
T6956 13421-13431 Positive_regulation denotes activation
T6948 10915-10924 Negative_regulation denotes prevented
T6947 10869-10875 Regulation denotes effect
T6946 10944-10954 Positive_regulation denotes activation
T6945 10894-10904 Positive_regulation denotes activation
T6944 10650-10657 Negative_regulation denotes absence
T6943 10666-10679 Gene_expression denotes co-expression
T6942 10406-10412 Regulation denotes effect
T6941 10490-10500 Gene_expression denotes expression
T6940 10453-10464 Gene_expression denotes transfected
T6939 10428-10438 Positive_regulation denotes activation
T6938 10347-10360 Positive_regulation denotes virus-induced
T6937 10366-10376 Positive_regulation denotes activation
T6936 10330-10341 Positive_regulation denotes upregulated
T6935 10261-10270 Gene_expression denotes expressed
T6934 10200-10208 Negative_regulation denotes inhibits
T6933 10214-10224 Positive_regulation denotes activation
T6932 9968-9975 Positive_regulation denotes induced
T6931 9922-9931 Positive_regulation denotes dependent
T6930 9979-9991 Gene_expression denotes transfection
T6929 9957-9967 Positive_regulation denotes activation
T6928 9792-9802 Positive_regulation denotes activation
T6927 9512-9519 Positive_regulation denotes induces
T6926 9524-9534 Positive_regulation denotes activation
T6925 9462-9469 Positive_regulation denotes induced
T6924 9447-9455 Negative_regulation denotes inhibits
T6923 9485-9495 Positive_regulation denotes activation
T6922 15168-15172 Protein denotes IRF3
T6921 15144-15149 Protein denotes RIG-I
T6920 14950-14954 Protein denotes IFNβ
T6919 14942-14945 Protein denotes TNF
T6918 14936-14940 Protein denotes IL-6
T6917 14865-14869 Protein denotes IRF3
T6916 14809-14813 Protein denotes IFNβ
T6915 14778-14782 Protein denotes IRF3
T6914 14759-14762 Protein denotes TNF
T6913 14750-14754 Protein denotes IL-6
T6912 14582-14586 Protein denotes IRF3
T6911 14577-14580 Protein denotes p65
T6910 14450-14454 Protein denotes IRF3
T6909 14275-14279 Protein denotes IKKε
T6908 14266-14270 Protein denotes TBK1
T6907 14142-14146 Protein denotes IRF3
T6906 13986-13989 Protein denotes p65
T6905 13926-13930 Protein denotes IκBα
T6904 13416-13420 Protein denotes IRF3
T6903 13391-13395 Protein denotes TLR3
T6902 13306-13310 Protein denotes MDA5
T6901 13288-13293 Protein denotes RIG-I
T6900 13100-13105 Protein denotes RIG-I
T6899 12505-12510 Protein denotes RIG-I
T6898 11068-11069 Protein denotes 7
T6897 11063-11067 Protein denotes IRF3
T6896 11039-11044 Protein denotes RIG-I
T6895 10939-10943 Protein denotes IRF7
T6894 10925-10930 Protein denotes RIG-I
T6893 10889-10893 Protein denotes IRF3
T6892 10837-10841 Protein denotes IRF7
T6891 10661-10665 Protein denotes IRF7
T6890 10587-10597 Protein denotes luciferase
T6889 10567-10571 Protein denotes IRF7
T6888 10485-10489 Protein denotes IRF7
T6887 10423-10427 Protein denotes IRF7
T6886 10361-10365 Protein denotes IRF3
T6885 10298-10302 Protein denotes IRF7
T6884 10239-10243 Protein denotes IRF7
T6883 10233-10237 Protein denotes IRF3
T6882 10209-10213 Protein denotes IRF7
T6881 9932-9942 Protein denotes luciferase
T6880 9917-9921 Protein denotes IRF3
T6879 10104-10109 Protein denotes RIG-I
T6878 10035-10040 Protein denotes RIG-I
T6877 9997-10031 Protein denotes truncated constitutive active form
T6876 9808-9813 Protein denotes RIG-I
T6875 9787-9791 Protein denotes IRF3
T6874 9554-9558 Protein denotes IRF7
T6873 9545-9549 Protein denotes IRF3
T6872 9496-9501 Protein denotes RIG-I
T6871 9480-9484 Protein denotes IRF3
T6870 9456-9461 Protein denotes RIG-I
T6955 13279-13287 Positive_regulation denotes activate
T6954 13270-13274 Binding denotes bind
T6953 13086-13095 Positive_regulation denotes stimulate
T6952 11045-11052 Positive_regulation denotes induced
T6951 11031-11038 Negative_regulation denotes inhibit
T6950 11070-11080 Positive_regulation denotes activation
T6949 10931-10938 Positive_regulation denotes induced
T3821 8471-8479 Regulation denotes regulate
T3820 6843-6851 Positive_regulation denotes mediated
T3819 6852-6863 Protein_catabolism denotes degradation
T3818 6593-6601 Negative_regulation denotes regulate
T3817 6388-6395 Positive_regulation denotes mediate
T3816 6424-6434 Positive_regulation denotes activation
T3815 6286-6296 Positive_regulation denotes activation
T3814 6113-6121 Regulation denotes regulate
T3813 6128-6136 Positive_regulation denotes mediated
T3812 5872-5884 Localization denotes translocates
T3811 5759-5768 Binding denotes associate
T3810 5265-5274 Negative_regulation denotes deficient
T3809 5219-5227 Positive_regulation denotes mediated
T3808 3197-3204 Positive_regulation denotes induces
T3807 3209-3219 Gene_expression denotes production
T3806 8527-8532 Protein denotes IRF-3
T3805 8491-8495 Protein denotes TLR3
T3804 8480-8485 Protein denotes RIG-I
T3803 7531-7536 Protein denotes IL-1R
T3802 7516-7520 Protein denotes TLR4
T3801 7490-7504 Protein denotes TNF receptor I
T3800 7062-7067 Protein denotes RBCK1
T3799 7046-7052 Protein denotes TRIM21
T3798 7035-7039 Protein denotes RAUL
T3797 6993-6997 Protein denotes IRF7
T3796 6984-6988 Protein denotes IRF3
T3795 6822-6827 Protein denotes TRAF3
T3794 6813-6817 Protein denotes MAVS
T3793 6782-6789 Protein denotes TRIAD3A
T3792 6768-6772 Protein denotes AIP4
T3791 6602-6605 Protein denotes RLR
T3790 6530-6534 Protein denotes CYLD
T3789 6519-6523 Protein denotes DUBA
T3758 3461-3465 Protein denotes IRF7
T3757 3452-3456 Protein denotes IRF3
T549 5-12 Protein denotes Tnfaip3
T553 14-24 Negative_regulation denotes Deficiency
T3756 3329-3334 Protein denotes IFN-β
T3755 3318-3323 Protein denotes IFN-α
T3754 3304-3316 Protein denotes interferon-α
T3753 3274-3278 Protein denotes IL-1
T3752 3265-3269 Protein denotes IL-6
T3751 3260-3263 Protein denotes TNF
T3788 6440-6445 Protein denotes RIG-I
T3787 6419-6423 Protein denotes IRF3
T3786 6377-6382 Protein denotes TRAF3
T3785 6356-6361 Protein denotes TRAF6
T3784 6280-6285 Protein denotes RIG-I
T3783 6225-6231 Protein denotes Riplet
T3782 6209-6215 Protein denotes TRIM25
T3781 6122-6127 Protein denotes RIG-I
T3780 6011-6015 Protein denotes MAVS
T3779 5828-5834 Protein denotes Cardif
T3778 5822-5826 Protein denotes VISA
T3777 5815-5820 Protein denotes IPS-1
T3776 5797-5801 Protein denotes MAVS
T3775 5753-5758 Protein denotes RIG-I
T3774 5581-5586 Protein denotes RIG-I
T3773 5330-5334 Protein denotes TLR3
T3772 5259-5264 Protein denotes RIG-I
T3771 5213-5218 Protein denotes RIG-I
T3770 5003-5008 Protein denotes RIG-I
T3769 4994-4998 Protein denotes TLR3
T3768 4054-4059 Protein denotes IFI16
T3767 4031-4035 Protein denotes AIM2
T3766 3982-3985 Protein denotes DAI
T3765 3976-3980 Protein denotes TLR9
T3764 3825-3829 Protein denotes TLR7
T3763 3880-3884 Protein denotes MDA5
T3762 3873-3878 Protein denotes RIG-I
T3761 3867-3871 Protein denotes TLR3
T3760 3837-3841 Protein denotes Nod2
T3759 3831-3835 Protein denotes TLR8
T550 433-462 Protein denotes pathogen recognition receptor
T551 463-468 Protein denotes RIG-I
T552 992-996 Protein denotes IRF3
T554 405-414 Positive_regulation denotes activates
T555 997-1007 Positive_regulation denotes activation
T556 973-981 Positive_regulation denotes enhanced
R8376 T11184 T11196 themeOf KC,higher
R8378 T11185 T11197 themeOf MCP-1,expression
R2965 T3795 T3819 themeOf TRAF3,degradation
R2970 T3804 T3821 themeOf RIG-I,regulate
R2972 T3806 T3821 causeOf IRF-3,regulate
R2974 T3807 T3808 themeOf production,induces
R2975 T3807 T3808 themeOf production,induces
R2976 T3807 T3808 themeOf production,induces
R2977 T3807 T3808 themeOf production,induces
R4986 T6887 T6939 themeOf IRF7,activation
R5084 T6937 T6938 themeOf activation,virus-induced
R2978 T3807 T3808 themeOf production,induces
R2980 T3813 T3814 themeOf mediated,regulate
R2981 T3816 T3817 themeOf activation,mediate
R2982 T3816 T3817 themeOf activation,mediate
R2985 T3819 T3820 themeOf degradation,mediated
R2986 T3819 T3820 themeOf degradation,mediated
R4960 T6870 T6925 causeOf RIG-I,induced
R4961 T6871 T6923 themeOf IRF3,activation
R4962 T6873 T6926 themeOf IRF3,activation
R4967 T6874 T6926 themeOf IRF7,activation
R4968 T6875 T6928 themeOf IRF3,activation
R4969 T6877 T6930 themeOf truncated constitutive active form,transfection
R4972 T6878 T6930 themeOf RIG-I,transfection
R4975 T6880 T6931 causeOf IRF3,dependent
R4976 T6881 T6929 themeOf luciferase,activation
R4977 T6882 T6933 themeOf IRF7,activation
R4979 T6883 T6935 themeOf IRF3,expressed
R4980 T6884 T6935 themeOf IRF7,expressed
R4982 T6885 T6936 themeOf IRF7,upregulated
R4984 T6886 T6937 themeOf IRF3,activation
R4989 T6888 T6940 themeOf IRF7,transfected
R4993 T6888 T6941 themeOf IRF7,expression
R4994 T6890 T6940 themeOf luciferase,transfected
R4997 T6891 T6943 themeOf IRF7,co-expression
R5000 T6893 T6945 themeOf IRF3,activation
R5001 T6894 T6949 causeOf RIG-I,induced
R5002 T6895 T6946 themeOf IRF7,activation
R5003 T6896 T6952 causeOf RIG-I,induced
R5004 T6897 T6950 themeOf IRF3,activation
R5005 T6900 T6953 themeOf RIG-I,stimulate
R5006 T6946 T6948 themeOf activation,prevented
R5007 T6946 T6949 themeOf activation,induced
R5008 T6901 T6954 themeOf RIG-I,bind
R5009 T6901 T6955 themeOf RIG-I,activate
R5010 T6902 T6954 themeOf MDA5,bind
R5011 T6949 T6946 themeOf induced,activation
R5012 T6902 T6955 themeOf MDA5,activate
R5013 T6950 T6951 themeOf activation,inhibit
R5014 T6950 T6952 themeOf activation,induced
R5015 T6904 T6956 themeOf IRF3,activation
R5016 T6952 T6950 themeOf induced,activation
R5017 T6905 T6958 themeOf IκBα,phosphorylation
R5018 T6956 T6957 themeOf activation,induce
R5019 T6905 T6959 themeOf IκBα,degradation
R5020 T6958 T6960 themeOf phosphorylation,increased
R5021 T6906 T6961 themeOf p65,translocation
R5022 T6961 T6962 themeOf translocation,enhanced
R5023 T6907 T6963 themeOf IRF3,activated
R5024 T6910 T6964 themeOf IRF3,phosphorylation
R5025 T6965 T6966 themeOf translocation,reached
R5026 T6967 T6969 themeOf expression,controls
R5027 T6967 T6969 themeOf expression,controls
R5028 T6912 T6965 themeOf IRF3,translocation
R5029 T6968 T6969 themeOf expression,controls
R5030 T6970 T6973 themeOf activation,enhanced
R5031 T6913 T6967 themeOf IL-6,expression
R5032 T6971 T6972 themeOf secreted,increased
R5033 T6971 T6972 themeOf secreted,increased
R5034 T6971 T6972 themeOf secreted,increased
R5035 T6974 T6975 themeOf activation,regulation
R5036 T6974 T6976 themeOf activation,induced
R5037 T6914 T6967 themeOf TNF,expression
R5038 T6976 T6974 themeOf induced,activation
R5039 T6916 T6968 themeOf IFNβ,expression
R5040 T6917 T6970 themeOf IRF3,activation
R5041 T6918 T6971 themeOf IL-6,secreted
R5043 T6918 T6972 themeOf IL-6,increased
R5044 T6919 T6971 themeOf TNF,secreted
R5048 T6919 T6972 themeOf TNF,increased
R5049 T6920 T6971 themeOf IFNβ,secreted
R5051 T6920 T6972 themeOf IFNβ,increased
R5054 T6921 T6976 causeOf RIG-I,induced
R5057 T6922 T6974 themeOf IRF3,activation
R5063 T6923 T6924 themeOf activation,inhibits
R5064 T6923 T6925 themeOf activation,induced
R5066 T6925 T6923 themeOf induced,activation
R5071 T6925 T6924 themeOf induced,inhibits
R5073 T6926 T6927 themeOf activation,induces
R5074 T6926 T6927 themeOf activation,induces
R5075 T6929 T6931 themeOf activation,dependent
R5076 T6930 T6932 themeOf transfection,induced
R5079 T6930 T6932 themeOf transfection,induced
R5080 T6933 T6934 themeOf activation,inhibits
R5087 T6937 T6936 themeOf activation,upregulated
R5090 T6938 T6937 themeOf virus-induced,activation
R5093 T6939 T6942 themeOf activation,effect
R5097 T6943 T6944 themeOf co-expression,absence
R5100 T6945 T6947 themeOf activation,effect
R5986 T8375 T8389 themeOf IL-6,expression
R5987 T8376 T8389 themeOf IFNβ,expression
R5988 T8377 T8391 themeOf TNF,higher
R5989 T8378 T8391 themeOf IFNβ,higher
R5990 T8379 T8392 themeOf ccl2,Expression
R5991 T8379 T8393 themeOf ccl2,secretion
R5992 T8380 T8392 themeOf KC,Expression
R5993 T8380 T8393 themeOf KC,secretion
R5994 T8381 T8392 themeOf cxcl1,Expression
R5995 T8381 T8393 themeOf cxcl1,secretion
R5996 T8382 T8392 themeOf IL-6,Expression
R5997 T8382 T8393 themeOf IL-6,secretion
R5998 T8383 T8392 themeOf TNF,Expression
R5999 T8383 T8393 themeOf TNF,secretion
R6000 T8384 T8392 themeOf IFNβ,Expression
R6001 T8385 T8392 themeOf IFNα4,Expression
R6002 T8386 T8392 themeOf MCP-1,Expression
R6003 T8386 T8393 themeOf MCP-1,secretion
R6004 T8388 T8394 themeOf IRF3,activation
R6005 T8389 T8390 themeOf expression,enhanced
R6006 T8389 T8390 themeOf expression,enhanced
R8380 T11190 T11198 themeOf KC,production
R8382 T11191 T11198 themeOf MIP-2,production
R8384 T11192 T11199 themeOf IL-6,increased
R8385 T11193 T11199 themeOf TNF,increased
R8386 T11194 T11199 themeOf IL-1β,increased
R8387 T11195 T11200 themeOf MCP-1,production
R8389 T11200 T11201 themeOf production,increased
R8390 T11200 T11202 themeOf production,lower
R10836 T14353 T14374 themeOf IRF3,regulating
R10837 T14355 T14375 themeOf ABIN1,ubiquitin-binding
R10838 T14356 T14376 themeOf TBK1,K63-polyubiquitination
R10839 T14357 T14376 themeOf IKKε,K63-polyubiquitination
R10840 T14359 T14378 themeOf RIG-I,activation
R10841 T14360 T14382 themeOf TBK1,ubiquitination
R10842 T14361 T14382 themeOf IKKε,ubiquitination
R10843 T14362 T14383 themeOf IRF3,activation
R10844 T14366 T14385 themeOf RIG-I,induced
R10845 T14342 T14367 themeOf MCP-1,affected
R10846 T14343 T14368 themeOf MCP-1,production
R10847 T14344 T14369 themeOf IRF3,activation
R10848 T14369 T14371 themeOf activation,enhanced
R10849 T14345 T14370 themeOf RIG-I,stimulation
R10850 T14347 T14373 themeOf RIG-I,enhanced
R10851 T14370 T14372 themeOf stimulation,response
R10852 T14372 T14370 themeOf response,stimulation
R10853 T14372 T14371 themeOf response,enhanced
R10854 T14376 T14377 themeOf K63-polyubiquitination,affecting
R10855 T14376 T14377 themeOf K63-polyubiquitination,affecting
R10856 T14378 T14379 themeOf activation,regulation
R10857 T14378 T14380 themeOf activation,induced
R10858 T14379 T14381 themeOf regulation,involved
R10859 T14379 T14378 themeOf regulation,activation
R10860 T14380 T14378 themeOf induced,activation
R10862 T14383 T14384 themeOf activation,mediate
R10866 T14385 T14386 themeOf induced,gatekeeper
R12399 T16437 T16443 themeOf Granzyme B,expressing
R12400 T16438 T16443 themeOf GrB,expressing
R12401 T16441 T16444 themeOf CD3,expression
R12402 T16442 T16444 themeOf CD8,expression
R12925 T17086 T17088 themeOf IRF3,expression
R12926 T17087 T17088 themeOf IRF7,expression
R15060 T20044 T20062 themeOf IRF3,activation
R15061 T20045 T20063 themeOf RIG-I,response
R15062 T20048 T20065 themeOf luciferase,dependent
R15063 T20049 T20066 themeOf IRF7,expressing
R15064 T20050 T20067 themeOf IκBα,phosphorylation
R15065 T20051 T20068 themeOf IRF3,phosphorylation
R15066 T20052 T20069 themeOf IRF3,translocation
R15067 T20053 T20069 themeOf p65,translocation
R15068 T20055 T20070 themeOf IRF3,expressed
R15069 T20062 T20064 themeOf activation,inhibits
R15070 T20062 T20063 themeOf activation,response
R15071 T20063 T20062 themeOf response,activation
R15072 T20063 T20062 themeOf response,activation
R15475 T20668 T20676 themeOf IL-6,expression
R15476 T20669 T20676 themeOf IFNβ,expression
R15477 T20672 T20677 themeOf IL-6,expression
R15478 T20673 T20677 themeOf IFNβ,expression
R500 T549 T553 themeOf Tnfaip3,Deficiency
R501 T550 T554 themeOf pathogen recognition receptor,activates
R502 T551 T554 themeOf RIG-I,activates
R503 T552 T555 themeOf IRF3,activation
R504 T555 T556 themeOf activation,enhanced
R2938 T3751 T3807 themeOf TNF,production
R2946 T3771 T3809 themeOf RIG-I,mediated
R2948 T3772 T3810 themeOf RIG-I,deficient
R2949 T3775 T3811 themeOf RIG-I,associate
R2950 T3776 T3811 themeOf MAVS,associate
R2951 T3777 T3812 themeOf IPS-1,translocates
R2973 T3807 T3808 themeOf production,induces
R2939 T3752 T3807 themeOf IL-6,production
R2940 T3753 T3807 themeOf IL-1,production
R2941 T3754 T3807 themeOf interferon-α,production
R2942 T3755 T3807 themeOf IFN-α,production
R2943 T3756 T3807 themeOf IFN-β,production
R2953 T3778 T3812 themeOf VISA,translocates
R2954 T3779 T3812 themeOf Cardif,translocates
R2955 T3781 T3813 themeOf RIG-I,mediated
R2957 T3784 T3815 themeOf RIG-I,activation
R2958 T3785 T3817 causeOf TRAF6,mediate
R2959 T3786 T3817 causeOf TRAF3,mediate
R2960 T3787 T3816 themeOf IRF3,activation
R2962 T3789 T3818 causeOf DUBA,regulate
R2963 T3791 T3818 themeOf RLR,regulate
R2964 T3794 T3819 themeOf MAVS,degradation

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue Negation
T644 5-12 Protein denotes Tnfaip3
T645 28-41 Entity denotes Myeloid Cells
T21616 25061-25066 Protein denotes MIP-2
T21615 25075-25079 Protein denotes IL-6
T21614 24767-24771 Protein denotes mice
T21613 25295-25299 Protein denotes mice
T21612 25145-25165 Entity denotes alveolar macrophages
T21611 24931-24934 Protein denotes BAL
T21610 25068-25073 Protein denotes MCP-1
T21609 25057-25059 Protein denotes KC
T21608 25084-25088 Protein denotes IFNα
T21607 25167-25178 Entity denotes neutrophils
T21606 25183-25199 Entity denotes monocytes in BAL
T21191 19357-19379 Regulation denotes from IAV infected mice
T21190 19565-19576 Entity denotes neutrophils
T21189 19594-19597 Protein denotes BAL
T21188 19409-19411 Protein denotes KC
T21187 19420-19425 Protein denotes MCP-1
T21186 19051-19066 Protein denotes A20myel-KO mice
T21185 19409-19455 Protein denotes KC, MIP-2, MCP-1, IL-6 and IFNα protein levels
T21184 18985-18998 Entity denotes myeloid cells
T21183 19413-19418 Protein denotes MIP-2
T21182 19703-19707 Protein denotes mice
T21181 19534-19563 Entity denotes resident alveolar macrophages
T21180 19427-19431 Protein denotes IL-6
T21179 19581-19597 Entity denotes monocytes in BAL
T21178 19436-19440 Protein denotes IFNα
T21177 19357-19379 Protein denotes from IAV infected mice
T21176 18967-18970 Protein denotes A20
T21175 19340-19343 Protein denotes BAL
T21605 24987-25019 Protein denotes A20myel-KO mice 6 days following
T21604 24931-24940 Entity denotes BAL fluid
T21603 25196-25199 Protein denotes BAL
T21602 24670-24683 Entity denotes myeloid cells
T21601 24652-24655 Protein denotes A20
T20750 15876-15961 Regulation denotes A20 negatively regulates IAV-induced gene expression in BMDM and alveolar macrophages
T20749 16122-16177 Gene_expression denotes IL-6, IFNβ and A20 mRNA expression was analyzed by qPCR
T20748 16122-16177 Transcription denotes IL-6, IFNβ and A20 mRNA expression was analyzed by qPCR
T20747 16409-16465 Transcription denotes IL-6 and IFNβ mRNA expression was determined by qPCR (C)
T20746 16409-16465 Gene_expression denotes IL-6 and IFNβ mRNA expression was determined by qPCR (C)
T20745 16137-16140 Protein denotes A20
T20744 16122-16145 Protein denotes IL-6, IFNβ and A20 mRNA
T20743 15876-15879 Protein denotes A20
T20742 16509-16513 Protein denotes IL-6
T20741 16409-16427 Protein denotes IL-6 and IFNβ mRNA
T20740 16128-16132 Protein denotes IFNβ
T20739 16101-16106 Entity denotes cells
T20738 16409-16413 Protein denotes IL-6
T20737 16418-16422 Protein denotes IFNβ
T20736 16327-16347 Entity denotes Alveolar macrophages
T20735 16257-16276 Protein denotes IFNβ protein levels
T20734 16518-16522 Protein denotes IFNβ
T20733 16257-16261 Protein denotes IFNβ
T20224 11928-11945 Regulation denotes a loading control
T20223 11180-11197 Positive_regulation denotes RIG-I stimulation
T20222 11706-11726 Phosphorylation denotes IκBα phosphorylation
T20221 11748-11786 Phosphorylation denotes IRF3 phosphorylation by immunoblotting
T20220 11149-11164 Positive_regulation denotes IRF3 activation
T20219 11234-11251 Protein denotes with NF-κB (left)
T20218 11972-11983 Protein denotes NF-κB (p65)
T20217 11801-11813 Entity denotes extracts (B)
T20216 11253-11266 Protein denotes IRF3 (middle)
T20215 11408-11414 Protein denotes of A20
T20214 11372-11384 Protein denotes IRF7 (right)
T20213 11787-11800 Entity denotes of total cell
T20212 11748-11752 Protein denotes IRF3
T20211 12263-12268 Entity denotes cells
T20210 12100-12111 Protein denotes nuclear p65
T20209 12327-12330 Protein denotes TNF
T20208 11180-11185 Protein denotes RIG-I
T20207 11416-11426 Protein denotes Luciferase
T20206 12221-12224 Protein denotes TNF
T20205 12335-12339 Protein denotes IFNβ
T20204 11149-11153 Protein denotes IRF3
T20203 11270-11274 Protein denotes IRF7
T20202 11439-11452 Entity denotes cell extracts
T20201 12116-12120 Protein denotes IRF3
T20200 11988-11992 Protein denotes IRF3
T20199 12310-12314 Protein denotes IL-6
T20198 11439-11452 Entity denotes cell extracts
T20197 11139-11144 Protein denotes NF-κB
T20196 11979-11982 Protein denotes p65
T20195 12244-12273 Entity denotes the supernatant of cells used
T20194 11706-11710 Protein denotes IκBα
T20193 11612-11621 Entity denotes poly(I:C)
T20192 11509-11516 Entity denotes SD of 3
T20191 11126-11129 Protein denotes A20
T20190 12215-12219 Protein denotes IL-6
T20189 11357-11362 Protein denotes RIG-I
T20188 11285-11295 Protein denotes luciferase
T20187 12229-12233 Protein denotes IFNβ
T20186 11860-11885 Entity denotes by the anti-IκBα antibody
T20732 16122-16126 Protein denotes IL-6
T20731 16518-16537 Protein denotes IFNβ protein levels
T20730 16112-16117 Protein denotes lysed
T20729 16249-16252 Protein denotes TNF
T20728 15941-15961 Entity denotes alveolar macrophages
T20727 16467-16491 Entity denotes Cell culture supernatant
T20726 16183-16231 Entity denotes 18 hours post infection cell culture supernatant
T19259 41479-41492 Protein denotes two-way ANOVA
T19258 41766-41783 Protein denotes Pad Prism version
T19257 41584-41602 Entity denotes the Mann-Whitney U
T19256 41538-41550 Protein denotes least 5 mice
T19255 41797-41800 Protein denotes San
T19254 41612-41620 Protein denotes unpaired
T19253 41792-41807 Protein denotes Pad, San Diego,
T18622 40319-40328 Entity denotes BAL fluid
T18621 40125-40130 Protein denotes IL-1β
T18620 39882-39886 Protein denotes IFNα
T18619 39757-39760 Protein denotes TNF
T18618 40319-40322 Protein denotes BAL
T18617 39800-39803 Protein denotes TNF
T18616 39870-39880 Entity denotes antibodies
T18615 40143-40146 Protein denotes BAL
T18614 40024-40028 Protein denotes IFNγ
T18613 39891-39895 Protein denotes IFNβ
T18612 40109-40114 Protein denotes MCP-1
T18611 40135-40139 Protein denotes IL-6
T18610 39729-39737 Protein denotes Cytokine
T18609 39980-39984 Protein denotes IFNγ
T18608 40307-40315 Protein denotes of MIP-2
T18607 40120-40123 Protein denotes TNF
T18606 40069-40094 Entity denotes antibodies (eBiosciences)
T18605 39891-39910 Protein denotes IFNβ protein levels
T18604 40116-40118 Protein denotes KC
T18603 40143-40152 Entity denotes BAL fluid
T19092 40370-40433 Negative_regulation denotes Total RNA was extracted using Aurum Total RNA mini kit (BioRad)
T19091 40346-40360 Entity denotes cDNA synthesis
T19090 40759-40763 Protein denotes IL-6
T19089 40670-40697 Protein denotes the following primers: HPRT
T19088 41354-41358 Protein denotes HPRT
T19087 40331-40334 Protein denotes RNA
T19086 40831-40835 Protein denotes IFNβ
T19085 41037-41042 Protein denotes CXCL1
T19084 41106-41111 Protein denotes IFNα4
T19083 40400-40405 Entity denotes Aurum
T19082 41302-41304 Protein denotes CT
T19081 40370-40379 Protein denotes Total RNA
T19080 40900-40903 Protein denotes A20
T19079 40966-40970 Protein denotes CCL2
T19078 40365-40369 Protein denotes qPCR
T19077 40473-40485 Entity denotes iScript cDNA
T19076 40412-40415 Protein denotes RNA
T19075 40583-40595 Entity denotes SYBR Green I
T17791 38164-38167 Entity denotes KCl
T17790 38254-38276 Entity denotes phosphatase inhibitors
T17789 37676-37684 Protein denotes protease
T17788 37831-37842 Entity denotes 5% glycerol
T17787 37648-37656 Entity denotes 2 mM DTT
T17786 37550-37555 Protein denotes lysed
T17785 38241-38249 Protein denotes protease
T17784 38115-38129 Entity denotes 20 mM Hepes pH
T17783 38590-38594 Entity denotes Cell
T17782 38554-38566 Protein denotes phospho-IRF3
T17781 37539-37544 Entity denotes cells
T17780 38211-38222 Entity denotes 0.1 mM EGTA
T17779 38254-38265 Protein denotes phosphatase
T17778 37890-37898 Protein denotes protease
T17777 38145-38156 Entity denotes 400 mM NaCl
T17776 37844-37855 Entity denotes 0.5 mM EDTA
T17775 38016-38021 Entity denotes cells
T17774 37591-37602 Entity denotes 200 mM NaCl
T17773 37614-37631 Entity denotes 10 mM Tris-HCl pH
T17772 37903-37914 Protein denotes phosphatase
T17771 37788-37802 Entity denotes 10 mM Hepes pH
T17770 38496-38523 Entity denotes anti-histon H1 (Santa Cruz)
T17769 37689-37700 Protein denotes phosphatase
T17768 37958-37967 Entity denotes detergent
T17767 37689-37711 Entity denotes phosphatase inhibitors
T17766 38121-38126 Entity denotes Hepes
T17765 37903-37925 Entity denotes phosphatase inhibitors
T17764 37759-37780 Entity denotes by resuspending cells
T17763 38111-38113 Entity denotes B2
T17762 37620-37628 Entity denotes Tris-HCl
T17761 37814-37817 Entity denotes KCl
T17760 38386-38389 Protein denotes ECL
T17759 37784-37786 Entity denotes B1
T17758 38181-38193 Entity denotes 20% glycerol
T17757 38739-38756 Entity denotes Gel analyzer tool
T17756 37794-37799 Entity denotes Hepes
T17755 37625-37628 Entity denotes HCl
T17754 37860-37871 Entity denotes 0.1 mM EGTA
T18225 39285-39294 Protein denotes F4/80 APC
T18224 38907-38921 Protein denotes 1 mg/ml; Sigma
T18223 39657-39673 Entity denotes Propidium iodide
T18222 39222-39274 Protein denotes MHC-II (I-A/I-E) FITC (M5/114.15.2), CD11c PerCP-Cy5
T18221 39523-39538 Protein denotes CD16/32 (2.4G2)
T18220 39159-39164 Entity denotes Cells
T18219 38886-38922 Protein denotes collagenase type IV (1 mg/ml; Sigma)
T18218 39239-39258 Entity denotes FITC (M5/114.15.2),
T18217 39436-39450 Protein denotes Ly6G PE (1A8),
T18216 39068-39080 Protein denotes BAL, trachea
T18215 39321-39343 Entity denotes Granzyme B FITC (NGZB)
T18214 39183-39204 Protein denotes monoclonal antibodies
T18213 39436-39440 Protein denotes Ly6G
T18212 38927-38932 Protein denotes DNAse
T18211 39321-39329 Protein denotes Granzyme
T18210 39148-39157 Entity denotes 1 mM EDTA
T18209 39230-39233 Entity denotes I-A
T18208 39302-39320 Protein denotes CD62L PE (MEL-14),
T18207 39495-39499 Protein denotes IFNγ
T18206 39015-39038 Entity denotes a 70 µm and 40 µm nylon
T18205 38886-38897 Protein denotes collagenase
T18204 39474-39478 Protein denotes CD8α
T18203 39707-39726 Entity denotes live and dead cells
T18202 39366-39369 Protein denotes CD3
T18201 39657-39666 Entity denotes Propidium
T18200 39302-39307 Protein denotes CD62L
T17753 38195-38206 Entity denotes 0.5 mM EDTA
T17752 37620-37628 Entity denotes Tris-HCl
T17751 38466-38481 Protein denotes A20, anti-IκBα,
T17750 38525-38548 Protein denotes anti-IRF3 (Invitrogen),
T17749 38622-38624 Protein denotes MP
T17748 37637-37657 Entity denotes 5 mM EDTA, 2 mM DTT)
T17747 38461-38524 Protein denotes anti-A20, anti-IκBα, anti-p65, and anti-histon H1 (Santa Cruz),
T17746 38610-38637 Protein denotes anti-actin (MP Biomedicals)
T17141 36073-36078 Entity denotes Cells
T17140 36482-36490 Entity denotes Medicine
T17139 37201-37226 Entity denotes CD11b specific antibodies
T17138 36173-36189 Entity denotes 2 mM L-glutamine
T17137 37035-37084 Entity denotes 10% FCS, 2 mM L-glutamine, 0.4 mM sodium pyruvate
T17136 36552-36556 Protein denotes IRF7
T17135 37246-37269 Entity denotes of alveolar macrophages
T17157 37271-37296 Binding denotes the trachea was canulated
T17156 37105-37128 Protein denotes ng/ml recombinant M-CSF
T17155 37044-37060 Entity denotes 2 mM L-glutamine
T17154 37444-37460 Entity denotes 2 mM L-glutamine
T17153 36728-36750 Protein denotes pACTbetagal (LMBP4341)
T17152 37351-37360 Entity denotes 1 mM EDTA
T17151 36539-36551 Protein denotes NF-κB, IRF3,
T17150 37362-37382 Entity denotes Alveolar macrophages
T17149 36729-36732 Protein denotes ACT
T17148 36268-36289 Entity denotes the calcium phosphate
T17147 36164-36213 Entity denotes 10% FCS, 2 mM L-glutamine, 0.4 mM sodium pyruvate
T17146 36506-36514 Entity denotes Medicine
T17145 37462-37484 Entity denotes 0.4 mM sodium pyruvate
T17144 36546-36550 Protein denotes IRF3
T17143 36957-36974 Entity denotes bone marrow cells
T17142 37489-37500 Entity denotes antibiotics
T16523 35514-35544 Regulation denotes treating the mice intranasally
T16522 35720-35739 Entity denotes 3 µg/ml Brefeldin A
T16521 35981-35985 Entity denotes aqua
T16520 36060-36070 Entity denotes dead cells
T16519 35963-35995 Entity denotes Live/Dead fixable aqua dead cell
T16518 35375-35444 Entity denotes In vivo intracellular GrB and IFNγ staining of activated CD8+ T cells
T16517 35741-35746 Entity denotes Cells
T16516 35523-35531 Protein denotes the mice
T16515 35617-35620 Protein denotes BAL
T16514 35397-35400 Protein denotes GrB
T16513 35569-35574 Protein denotes Sigma
T16512 35876-35888 Entity denotes CD8+ T cells
T16511 35606-35609 Entity denotes 6 h
T16510 35405-35409 Protein denotes IFNγ
T16509 35457-35460 Protein denotes GrB
T16508 35466-35470 Protein denotes IFNγ
T16507 35466-35494 Entity denotes IFNγ expressing CD8+ T cells
T16506 35649-35672 Entity denotes single cell suspensions
T16505 35422-35444 Entity denotes activated CD8+ T cells
T16504 35550-35575 Entity denotes 50 µg Brefeldin A (Sigma)
T16503 35445-35453 Protein denotes Granzyme
T16070 34788-34826 Binding denotes To remove sialic acid binding proteins
T16069 35269-35276 Protein denotes of sera
T16068 34384-34417 Entity denotes HAI (hemagglutination inhibition)
T16067 34913-34932 Entity denotes a two-fold dilution
T16066 34442-34445 Protein denotes HAI
T16065 34531-34558 Entity denotes RDE/Cholera filtrate; Sigma
T16064 34465-34469 Protein denotes mice
T16063 34531-34558 Protein denotes RDE/Cholera filtrate; Sigma
T16062 34940-34947 Protein denotes of sera
T16061 34570-34582 Entity denotes sialic acids
T16060 34828-34832 Protein denotes sera
T16059 34875-34878 Protein denotes RBC
T16058 34955-34957 Entity denotes HA
T16057 34798-34809 Entity denotes sialic acid
T16056 34471-34484 Protein denotes sera of these
T16055 34818-34826 Protein denotes proteins
T16054 35078-35081 Protein denotes RBC
T16053 34583-34651 Protein denotes from serum proteins capable of aspecific inhibition of agglutination
T16052 34725-34755 Entity denotes of 0.75% sodium citrate in PBS
T15277 32961-32990 Regulation denotes individually ventilated cages
T15276 33274-33332 Gene_expression denotes A20fl/fl mice expressing or lacking the LysM-Cre transgene
T15275 32857-32896 Gene_expression denotes to generate A20fl/fl LysMCre transgenes
T15274 32767-32776 Protein denotes mice [84]
T15273 33314-33322 Entity denotes LysM-Cre
T15272 33201-33209 Entity denotes LysM-Cre
T15271 32941-32945 Protein denotes Mice
T15270 32667-32680 Protein denotes A20fl/fl mice
T15269 32961-32990 Protein denotes individually ventilated cages
T15268 33274-33332 Protein denotes A20fl/fl mice expressing or lacking the LysM-Cre transgene
T15267 32662-32666 Protein denotes Mice
T15266 33314-33322 Entity denotes LysM-Cre
T15265 32726-32739 Protein denotes A20fl/fl mice
T15264 33206-33209 Protein denotes Cre
T15263 33310-33332 Protein denotes the LysM-Cre transgene
T15262 32758-32801 Protein denotes LysM-Cre mice [84] (provided by I. Förster,
T15261 33319-33322 Protein denotes Cre
T15260 33201-33209 Entity denotes LysM-Cre
T15259 32758-32801 Entity denotes LysM-Cre mice [84] (provided by I. Förster,
T15258 32869-32896 Protein denotes A20fl/fl LysMCre transgenes
T15257 32994-33001 Entity denotes the VIB
T15656 34039-34094 Entity denotes MDCK cells for 5 days in DMEM supplemented with trypsin
T15655 34106-34122 Entity denotes 2 mM L-glutamine
T15654 34124-34146 Entity denotes 0.4 mM sodium pyruvate
T15653 34178-34212 Entity denotes 0.5% chicken red blood cells (RBC)
T15652 34208-34211 Entity denotes RBC
T15651 33552-33556 Protein denotes mice
T15650 34087-34094 Entity denotes trypsin
T15649 33739-33743 Protein denotes mice
T15648 33598-33617 Entity denotes ketamine (12 mg/kg)
T14989 32541-32545 Protein denotes Mice
T14988 32334-32337 Entity denotes EEG
T14987 32301-32337 Entity denotes EU Directives 2010/63/EU, 86/609/EEG
T14986 32616-32635 Entity denotes ketamine (12 mg/kg)
T14985 32603-32659 Entity denotes a mixture of ketamine (12 mg/kg) and xylazine (60 mg/kg)
T14984 32469-32471 Protein denotes ID
T14983 32168-32172 Protein denotes mice
T14765 28071-28096 Binding denotes on neutrophil recruitment
T14764 26056-26139 Binding denotes attract innate immune cells to the lung during the primary phase of infection [69],
T14763 26636-26689 Binding denotes neutrophil attracting chemokines such as KC and MIP-2
T14762 26636-26689 Binding denotes neutrophil attracting chemokines such as KC and MIP-2
T14761 27328-27347 Gene_expression denotes of MCP-1 production
T14760 30406-30437 Gene_expression denotes A20 expression in myeloid cells
T14759 29506-29540 Regulation denotes in the regulation of RIG-I induced
T14758 26750-26814 Localization denotes IL-1β in the lungs of A20myel-KO mice compared to wild type mice
T14757 29271-29287 Binding denotes binding proteins
T14756 29598-29717 Ubiquitination denotes to clearly detect ubiquitination of TBK1 and IKKε in primary macrophages, preventing us from studying the effect of A20
T14755 29598-29717 Ubiquitination denotes to clearly detect ubiquitination of TBK1 and IKKε in primary macrophages, preventing us from studying the effect of A20
T14754 29349-29417 Regulation denotes thereby negatively affecting K63-polyubiquitination of TBK1 and IKKε
T14753 29349-29417 Regulation denotes thereby negatively affecting K63-polyubiquitination of TBK1 and IKKε
T14752 30465-30478 Gene_expression denotes RIG-I induced
T14751 30465-30478 Positive_regulation denotes RIG-I induced
T14750 29378-29417 Ubiquitination denotes K63-polyubiquitination of TBK1 and IKKε
T14749 29378-29417 Ubiquitination denotes K63-polyubiquitination of TBK1 and IKKε
T14748 29312-29339 Negative_regulation denotes disrupt the TRAF3-TBK1-IKKε
T14747 29312-29339 Negative_regulation denotes disrupt the TRAF3-TBK1-IKKε
T14746 29312-29339 Negative_regulation denotes disrupt the TRAF3-TBK1-IKKε
T14745 29155-29191 Positive_regulation denotes of different signaling proteins [80]
T14744 28916-29048 Regulation denotes this does not exclude an additional effect of A20 on other signaling pathways that may contribute to proinflammatory gene expression true
T14743 25470-25484 Gene_expression denotes A20 expression
T14742 30143-30158 Positive_regulation denotes RIG-I signaling
T14741 28361-28376 Positive_regulation denotes IRF3 activation
T14740 28675-28736 Negative_regulation denotes that A20 inhibits IAV-induced proinflammatory gene expression
T14739 29300-29347 Binding denotes ABIN1 to to disrupt the TRAF3-TBK1-IKKε complex
T14738 30465-30488 Positive_regulation denotes RIG-I induced signaling
T14737 26868-26926 Binding denotes neutrophil recruitment to the bronchoalveolar compartment,
T14736 28638-28662 Positive_regulation denotes enhanced RIG-I signaling
T14735 28638-28662 Positive_regulation denotes enhanced RIG-I signaling
T14734 28836-28852 Positive_regulation denotes IRF3 activation,
T14733 28392-28409 Positive_regulation denotes RIG-I stimulation
T14732 28863-28905 Regulation denotes the major pathways controlling these genes
T14731 29541-29557 Positive_regulation denotes NF-κB activation
T14730 29853-29868 Positive_regulation denotes IRF3 activation
T14729 26196-26216 Entity denotes Alveolar macrophages
T14728 28053-28070 Protein denotes of A20 deficiency
T14727 27867-27891 Protein denotes proinflammatory cytokine
T14726 28074-28084 Entity denotes neutrophil
T14725 29324-29329 Protein denotes TRAF3
T14724 26040-26050 Protein denotes chemokines
T14723 30650-30709 Entity denotes other cell types that are implicated in the response to IAV
T14722 26064-26083 Entity denotes innate immune cells
T14721 28351-28356 Protein denotes NF-κB
T14720 27225-27238 Entity denotes myeloid cells
T14719 29634-29638 Protein denotes TBK1
T14718 30406-30409 Protein denotes A20
T14717 30090-30098 Protein denotes A20 [49]
T14716 29261-29287 Protein denotes ubiquitin-binding proteins
T14715 28784-28789 Protein denotes MIP-2
T14714 27375-27417 Protein denotes Mice deficient for the MCP-1 receptor CCR2
T14713 29711-29717 Protein denotes of A20
T14712 26282-26290 Protein denotes antibody
T14711 29257-29295 Protein denotes the ubiquitin-binding proteins TAX1BP1
T14710 29237-29240 Protein denotes A20
T14709 30029-30033 Protein denotes DUBs
T14708 29261-29287 Protein denotes ubiquitin-binding proteins
T14707 28836-28840 Protein denotes IRF3
T14706 28774-28778 Protein denotes IL-6
T14705 30465-30478 Protein denotes RIG-I induced
T14704 25488-25501 Entity denotes myeloid cells
T14703 27013-27027 Entity denotes of neutrophils
T14702 29330-29334 Protein denotes TBK1
T14701 29378-29381 Entity denotes K63
T14700 27169-27174 Protein denotes MCP-1
T14699 28894-28905 Protein denotes these genes
T14698 25907-25976 Entity denotes of the first cells that encounter infectious IAV particles [67], [68]
T14697 28392-28397 Protein denotes RIG-I
T14696 28647-28652 Protein denotes RIG-I
T14695 29524-29532 Protein denotes of RIG-I
T14694 29643-29647 Protein denotes IKKε
T14693 27281-27304 Entity denotes airway epithelial cells
T14692 25585-25596 Entity denotes macrophages
T14691 28213-28224 Entity denotes neutrophils
T14690 30020-30035 Protein denotes enzymes (DUBs),
T14689 27215-27221 Protein denotes of A20
T14688 30364-30368 Protein denotes mice
T14687 31297-31306 Entity denotes antiviral
T14686 29079-29084 Protein denotes NF-κB
T14685 31119-31126 Entity denotes vaccine
T14684 27394-27417 Protein denotes the MCP-1 receptor CCR2
T14683 29988-30002 Entity denotes Multiple other
T14682 29271-29287 Protein denotes binding proteins
T14681 26417-26432 Protein denotes A20myel-KO mice
T14680 30162-30167 Protein denotes NF-κB
T14679 25811-25831 Entity denotes alveolar macrophages
T14678 26750-26814 Protein denotes IL-1β in the lungs of A20myel-KO mice compared to wild type mice
T14677 27928-27946 Entity denotes inflammatory cells
T14676 28959-28965 Protein denotes of A20
T14675 28795-28799 Protein denotes IFNβ
T14674 31252-31264 Protein denotes RNA (siRNA),
T14673 29300-29347 Protein denotes ABIN1 to to disrupt the TRAF3-TBK1-IKKε complex
T14672 31999-32005 Protein denotes of A20
T14671 27121-27135 Entity denotes of these cells
T14670 28310-28318 Protein denotes that A20
T14669 30556-30574 Protein denotes for A20 deficiency
T14668 29813-29885 Entity denotes other substrates that mediate NF-κB and IRF3 activation in myeloid cells
T14667 27758-27773 Protein denotes A20myel-KO mice
T14666 29324-29339 Protein denotes TRAF3-TBK1-IKKε
T14665 27589-27604 Entity denotes these monocytes
T14664 31778-31791 Entity denotes the antiviral
T14663 26471-26480 Protein denotes cytokines
T14662 28680-28683 Protein denotes A20
T14661 26658-26679 Protein denotes chemokines such as KC
T14660 28769-28772 Protein denotes TNF
T14659 29089-29093 Protein denotes IRF3
T14658 29449-29458 Protein denotes IRF3 [81]
T14657 31902-31934 Entity denotes small compound inhibitors of A20
T14656 26694-26740 Protein denotes several proinflammatory cytokines such as IL-6
T14655 29541-29546 Protein denotes NF-κB
T14654 26694-26735 Protein denotes several proinflammatory cytokines such as
T14653 29906-29925 Entity denotes of these substrates
T14652 29050-29053 Protein denotes A20
T14651 26007-26035 Protein denotes of proinflammatory cytokines
T14650 27394-27417 Protein denotes the MCP-1 receptor CCR2
T14649 26658-26676 Protein denotes chemokines such as
T14648 26797-26814 Protein denotes to wild type mice
T14647 30044-30054 Protein denotes DUBA [28],
T14646 31131-31140 Entity denotes antiviral
T14645 29413-29417 Protein denotes IKKε
T14644 26636-26689 Entity denotes neutrophil attracting chemokines such as KC and MIP-2
T14643 25903-25976 Entity denotes one of the first cells that encounter infectious IAV particles [67], [68]
T14642 25941-25976 Entity denotes infectious IAV particles [67], [68]
T14641 30815-30851 Entity denotes of innate antiviral immune responses
T14640 30143-30148 Protein denotes RIG-I
T14639 29651-29671 Entity denotes primary macrophages,
T14638 30424-30437 Entity denotes myeloid cells
T14637 29872-29885 Entity denotes myeloid cells
T14636 26506-26523 Protein denotes to wild type mice
T14635 31931-31934 Protein denotes A20
T14634 31854-31857 Protein denotes A20
T14633 26868-26878 Entity denotes neutrophil
T14632 26490-26496 Protein denotes I IFNs
T14631 30172-30177 Protein denotes IRF-3
T14630 26459-26469 Protein denotes chemokines
T14629 29155-29191 Protein denotes of different signaling proteins [80]
T14628 29843-29848 Protein denotes NF-κB
T14627 25726-25746 Entity denotes alveolar macrophages
T14626 27650-27682 Entity denotes proinflammatory macrophages [77]
T14625 32090-32094 Protein denotes SARS
T14624 28195-28224 Entity denotes monocytes and not neutrophils
T14623 28448-28453 Protein denotes RIG-I
T14622 30527-30537 Protein denotes other DUBs
T14621 28361-28365 Protein denotes IRF3
T14620 29791-29799 Protein denotes that A20
T14619 30610-30613 Protein denotes A20
T14618 27618-27646 Entity denotes inflammatory dendritic cells
T14617 26769-26787 Protein denotes of A20myel-KO mice
T14616 30044-30070 Protein denotes DUBA [28], CYLD [29], [30]
T14615 28780-28782 Protein denotes KC
T14614 25470-25473 Protein denotes A20
T14613 26383-26403 Entity denotes alveolar macrophages
T14612 29853-29857 Protein denotes IRF3
T14611 31372-31420 Entity denotes potent inhibitors of influenza virus replication
T14610 26742-26745 Protein denotes TNF
T14609 30072-30084 Protein denotes OTUB1/2 [31]
T14608 30719-30741 Entity denotes lung epithelial cells,
T14607 27465-27474 Entity denotes monocytes
T14606 26298-26314 Entity denotes viral particles,
T14605 25680-25700 Entity denotes alveolar macrophages
T14604 27331-27336 Protein denotes MCP-1
T14603 27398-27403 Protein denotes MCP-1
T14602 26178-26194 Protein denotes type I IFNs [70]
T14601 28826-28831 Protein denotes NF-κB
T14600 26684-26689 Protein denotes MIP-2
T14599 28115-28136 Entity denotes inflammatory monocyte
T14598 29404-29408 Protein denotes TBK1
T14597 28602-28606 Protein denotes mice
T11438 21611-21614 Protein denotes CTL
T11437 20501-20512 Protein denotes while MCP-1
T11436 22249-22262 Entity denotes myeloid cells
T11435 20427-20431 Protein denotes IL-8
T11434 23223-23238 Protein denotes A20myel-KO mice
T11433 22311-22329 Protein denotes hemagglutinin (HA)
T11432 24239-24247 Entity denotes monocyte
T11431 19910-19928 Protein denotes several chemokines
T11430 24201-24229 Protein denotes A20myel-KO mice (figure 4C),
T11429 20033-20057 Protein denotes KC and MIP-2 chemokines,
T11428 21999-22007 Protein denotes IFNγ CD8
T11427 20117-20120 Protein denotes BAL
T11426 21492-21501 Entity denotes cytotoxic
T11425 21376-21406 Protein denotes mock infected mice (figure 3D)
T11424 22567-22580 Entity denotes myeloid cells
T11423 24148-24153 Protein denotes MCP-1
T11422 17717-17720 Protein denotes A20
T11421 22742-22753 Entity denotes neutrophils
T11420 23850-23864 Entity denotes of neutrophils
T11419 20033-20035 Protein denotes KC
T11418 20673-20675 Protein denotes KC
T11417 21927-21969 Protein denotes wild type mice (figure S2A and figure S2C)
T11416 17642-17655 Entity denotes myeloid cells
T11415 21684-21688 Protein denotes IFNγ
T11414 20466-20500 Protein denotes a chemoattractant for neutrophils,
T11413 23744-23761 Protein denotes to wild type mice
T11412 24301-24305 Protein denotes mice
T11411 20680-20685 Protein denotes MIP-2
T11410 23950-23954 Protein denotes IL-6
T11409 22845-22860 Protein denotes A20myel-KO mice
T11408 17814-17829 Protein denotes A20myel-KO mice
T11407 22028-22032 Protein denotes IFNγ
T11406 20257-20276 Entity denotes primary macrophages
T11405 21805-21820 Entity denotes in CD8+ T cells
T11404 22326-22328 Entity denotes HA
T11403 23666-23678 Protein denotes pulmonary KC
T11402 18150-18160 Entity denotes BAL fluid,
T11401 24128-24138 Protein denotes figure S3A
T11400 20323-20328 Protein denotes MCP-1
T11399 21303-21318 Protein denotes A20myel-KO mice
T11398 20457-20462 Protein denotes MIP-2
T11397 20987-21010 Entity denotes monocyte (CD11b+ Ly6C+)
T11396 23072-23096 Entity denotes of proinflammatory cells
T11395 21730-21733 Protein denotes BAL
T11394 21555-21558 Protein denotes A20
T11393 20890-20894 Protein denotes mice
T11392 24492-24505 Entity denotes myeloid cells
T11391 17624-17627 Protein denotes A20
T11390 21165-21173 Protein denotes of MCP-1
T11389 21636-21643 Entity denotes T cells
T11514 21376-21406 Regulation denotes mock infected mice (figure 3D)
T11513 20945-21047 Positive_regulation denotes we could detect a significant increase in monocyte (CD11b+ Ly6C+) recruitment at day 4 post infection,
T11512 24148-24182 Positive_regulation denotes MCP-1 production was not increased
T11511 24239-24259 Binding denotes monocyte recruitment
T11510 21139-21196 Gene_expression denotes with the equal expression of MCP-1 in both groups of mice
T11509 24148-24164 Gene_expression denotes MCP-1 production
T11508 22546-22580 Gene_expression denotes by A20 expression in myeloid cells
T11507 20984-21047 Binding denotes in monocyte (CD11b+ Ly6C+) recruitment at day 4 post infection,
T11506 20164-20206 Regulation denotes to IAV infected wild type mice (figure 3C)
T11505 23971-24037 Binding denotes which are often associated with immunopathogenesis in humans [64],
T11504 20332-20347 Gene_expression denotes IFNα production
T11503 22028-22063 Gene_expression denotes IFNγ expression levels in the lungs
T11502 23683-23699 Gene_expression denotes MIP-2 production
T11501 17714-17731 Gene_expression denotes of A20 expression
T11500 24370-24379 Entity denotes antiviral
T11499 21999-22003 Protein denotes IFNγ
T11498 18527-18531 Protein denotes mice
T11497 20595-20606 Entity denotes macrophages
T11496 23427-23450 Protein denotes increased total protein
T11495 20696-20711 Protein denotes A20myel-KO mice
T11494 18150-18153 Protein denotes BAL
T11493 21597-21624 Entity denotes the antiviral CTL response,
T11492 18790-18796 Protein denotes of A20
T11491 18800-18813 Entity denotes myeloid cells
T11490 20488-20499 Entity denotes neutrophils
T11489 24474-24505 Protein denotes A20 deficiency in myeloid cells
T11488 22776-22799 Entity denotes of alveolar macrophages
T11487 21625-21703 Protein denotes total CD8+ T cells and virus specific Granzyme B (GrB) and IFNγ expressing CD8
T11486 23964-23970 Protein denotes IL-1β,
T11485 20554-20563 Entity denotes monocytes
T11484 18730-18763 Protein denotes of all wild type mice (figure 3B)
T11483 20164-20206 Protein denotes to IAV infected wild type mice (figure 3C)
T11482 18494-18509 Protein denotes A20myel-KO mice
T11481 22096-22102 Protein denotes of A20
T11480 21663-21679 Protein denotes Granzyme B (GrB)
T11479 24080-24084 Protein denotes mice
T11478 18335-18367 Protein denotes A20myel-KO mice (data not shown)
T11477 21198-21241 Entity denotes The number of resident alveolar macrophages
T11476 22549-22552 Protein denotes A20
T11475 18125-18160 Protein denotes protein concentration in BAL fluid,
T11474 22311-22398 Protein denotes hemagglutinin (HA) antibody titers in the serum of A20myel-KO and wild type littermates
T11473 21782-21786 Protein denotes mice
T11472 23341-23356 Protein denotes A20myel-KO mice
T11471 23100-23115 Protein denotes A20myel-KO mice
T11470 23257-23279 Protein denotes while all control mice
T11469 18648-18652 Protein denotes mice
T11468 17907-17911 Entity denotes H3N2
T11467 22009-22016 Entity denotes T cells
T11466 20532-20564 Protein denotes a chemoattractant for monocytes,
T11465 20724-20766 Entity denotes of neutrophils (CD11b+ Ly6C+ Ly6G+ F4/80−)
T11464 20150-20154 Protein denotes mice
T11463 21474-21520 Entity denotes of virus specific cytotoxic CD8+ T cells (CTL)
T11462 21675-21678 Protein denotes GrB
T11461 22106-22119 Entity denotes myeloid cells
T11460 20040-20045 Protein denotes MIP-2
T11459 21705-21712 Entity denotes T cells
T11458 20069-20073 Protein denotes IL-6
T11457 18292-18307 Protein denotes A20myel-KO mice
T11456 23956-23959 Protein denotes TNF
T11455 19821-19834 Entity denotes myeloid cells
T11454 21192-21196 Protein denotes mice
T11453 20759-20764 Protein denotes F4/80
T11452 21573-21586 Entity denotes myeloid cells
T11451 21516-21519 Protein denotes CTL
T11450 19803-19834 Protein denotes A20 deficiency in myeloid cells
T11449 17735-17748 Entity denotes myeloid cells
T11448 24401-24404 Entity denotes 6 h
T11447 23683-23688 Protein denotes MIP-2
T11446 20332-20336 Protein denotes IFNα
T11445 21991-21994 Protein denotes GrB
T11444 22239-22245 Protein denotes of A20
T11443 17980-17984 Protein denotes mice
T11442 19974-19977 Protein denotes BAL
T11441 23472-23475 Protein denotes BAL
T11440 19933-19942 Protein denotes cytokines
T11439 20396-20398 Protein denotes KC
T8528 17186-17194 Protein denotes IFN IFNβ
T8527 15340-15374 Entity denotes antiviral innate immune responses,
T8526 17567-17573 Protein denotes of A20
T8525 17363-17372 Entity denotes figure S1
T8524 17000-17011 Entity denotes these cells
T8523 16741-16761 Entity denotes alveolar macrophages
T8522 17170-17174 Protein denotes TNF,
T8521 15209-15212 Protein denotes A20
T8520 15507-15520 Protein denotes A20 deficient
T8519 15666-15694 Entity denotes to control cells (figure 2A)
T8518 17186-17189 Protein denotes IFN
T8517 17307-17310 Protein denotes A20
T8516 15387-15400 Protein denotes A20 deficient
T8515 17151-17160 Protein denotes cytokines
T8514 17579-17601 Protein denotes on RIG-I-induced NF-κB
T8513 16803-16813 Protein denotes chemokines
T8512 17209-17229 Protein denotes the chemokines MCP-1
T8511 15246-15250 Protein denotes gene
T8510 15806-15809 Protein denotes TNF
T8558 17606-17621 Positive_regulation denotes IRF3 activation
T8557 15604-15636 Gene_expression denotes expression of IL-6 and IFNβ mRNA
T8556 15604-15636 Gene_expression denotes expression of IL-6 and IFNβ mRNA
T8555 17579-17601 Gene_expression denotes on RIG-I-induced NF-κB
T8554 17579-17601 Positive_regulation denotes on RIG-I-induced NF-κB
T8553 17540-17601 Regulation denotes with the inhibitory effect of A20 seen on RIG-I-induced NF-κB
T8552 16913-16986 Regulation denotes A20 directly controls IAV-induced gene expression in alveolar macrophages
T8551 17606-17610 Protein denotes IRF3
T8550 15627-15631 Protein denotes IFNβ
T8549 17231-17235 Protein denotes ccl2
T8548 17421-17424 Protein denotes A20
T8547 17245-17250 Protein denotes cxcl1
T8546 17478-17487 Entity denotes antiviral
T8545 15440-15443 Protein denotes A20
T8544 16966-16986 Entity denotes alveolar macrophages
T8543 15814-15830 Protein denotes IFNβ (figure 2B)
T8542 17209-17229 Protein denotes the chemokines MCP-1
T8541 17507-17527 Entity denotes alveolar macrophages
T8540 17199-17204 Protein denotes IFNα4
T8539 15294-15319 Protein denotes of A20 in the IAV-induced
T8538 15767-15778 Entity denotes these cells
T8537 17161-17165 Protein denotes IL-6
T8536 15627-15636 Protein denotes IFNβ mRNA
T8535 17241-17251 Protein denotes KC (cxcl1)
T8534 17320-17373 Entity denotes to infected wild type cells (figure 2C and figure S1)
T8533 17582-17595 Protein denotes RIG-I-induced
T8532 15618-15622 Protein denotes IL-6
T8531 16913-16916 Protein denotes A20
T8530 15433-15437 Entity denotes H3N2
T8529 16789-16798 Protein denotes cytokines
T7570 14828-14869 Positive_regulation denotes the enhanced activation of NF-κB and IRF3
T7569 14828-14869 Positive_regulation denotes the enhanced activation of NF-κB and IRF3
T7568 12872-12965 Gene_expression denotes mice with transgenic mice expressing Cre recombinase under control of the lysozyme M promoter
T7567 9596-9695 Gene_expression denotes the expression of proinflammatory cytokines and type I IFNs that restrict further viral propagation
T7566 9596-9695 Gene_expression denotes the expression of proinflammatory cytokines and type I IFNs that restrict further viral propagation
T7565 9496-9511 Positive_regulation denotes RIG-I signaling
T7564 14828-14869 Positive_regulation denotes the enhanced activation of NF-κB and IRF3
T7563 14828-14869 Positive_regulation denotes the enhanced activation of NF-κB and IRF3
T7562 13416-13431 Positive_regulation denotes IRF3 activation
T7561 11063-11080 Positive_regulation denotes IRF3/7 activation
T7560 11063-11080 Positive_regulation denotes IRF3/7 activation
T7559 15130-15149 Regulation denotes regulation of RIG-I
T7558 10889-10905 Positive_regulation denotes IRF3 activation,
T7557 9582-9695 Positive_regulation denotes which promote the expression of proinflammatory cytokines and type I IFNs that restrict further viral propagation
T7556 9582-9695 Positive_regulation denotes which promote the expression of proinflammatory cytokines and type I IFNs that restrict further viral propagation
T7555 9861-9879 Gene_expression denotes A20 overexpression
T7554 9861-9879 Positive_regulation denotes A20 overexpression
T7553 13901-13942 Protein_catabolism denotes sustained degradation of IκBα (figure 1B)
T7552 9848-9912 Negative_regulation denotes we show that A20 overexpression in HEK293T cells prevents NF-κB-
T7551 9848-9912 Negative_regulation denotes we show that A20 overexpression in HEK293T cells prevents NF-κB-
T7550 13083-13115 Positive_regulation denotes To stimulate the RIG-I receptor,
T7549 10389-10439 Regulation denotes To determine the effect of A20 on IRF7 activation,
T7548 14442-14470 Phosphorylation denotes maximum IRF3 phosphorylation
T7547 14732-14762 Gene_expression denotes the expression of IL-6 and TNF
T7546 14732-14762 Gene_expression denotes the expression of IL-6 and TNF
T7545 9787-9802 Positive_regulation denotes IRF3 activation
T7527 13871-13896 Positive_regulation denotes increased phosphorylation
T7526 10658-10679 Gene_expression denotes of IRF7 co-expression
T7525 10420-10438 Positive_regulation denotes on IRF7 activation
T7524 9480-9495 Positive_regulation denotes IRF3 activation
T7523 13829-13854 Positive_regulation denotes enhanced NF-κB activation
T7522 13226-13235 Entity denotes poly(I:C)
T7521 9808-9813 Protein denotes RIG-I
T7520 14205-14241 Entity denotes of carboxyl terminal serine residues
T7519 14685-14715 Entity denotes to wild type cells (figure 1C)
T7518 14450-14454 Protein denotes IRF3
T7517 10925-10938 Protein denotes RIG-I-induced
T7516 9906-9912 Protein denotes NF-κB-
T7515 14778-14782 Protein denotes IRF3
T7514 10485-10489 Protein denotes IRF7
T7513 9952-9956 Protein denotes gene
T7512 14865-14869 Protein denotes IRF3
T7511 9787-9791 Protein denotes IRF3
T7510 13416-13420 Protein denotes IRF3
T7509 10556-10559 Protein denotes A20
T7508 10618-10631 Protein denotes RIG-I (2CARD)
T7507 13802-13821 Entity denotes A20 deficient cells
T7506 10906-10909 Protein denotes A20
T7505 14657-14660 Protein denotes A20
T7504 10191-10194 Protein denotes A20
T7503 12781-12784 Protein denotes A20
T7502 9456-9475 Protein denotes RIG-I-induced NF-κB
T7501 10837-10841 Protein denotes IRF7
T7500 13379-13411 Protein denotes significant TLR3 dependent NF-κB
T7499 9545-9549 Protein denotes IRF3
T7498 10423-10427 Protein denotes IRF7
T7497 13829-13854 Protein denotes enhanced NF-κB activation
T7496 14393-14401 Protein denotes antibody
T7495 12882-12897 Protein denotes transgenic mice
T7494 12840-12843 Protein denotes lox
T7493 12767-12855 Protein denotes a conditional A20 allele in which exon IV and exon V were flanked by two loxP sites [56]
T7492 10035-10046 Protein denotes RIG-I [53],
T7491 15004-15043 Entity denotes peritoneal macrophages (data not shown)
T7490 9456-9469 Protein denotes RIG-I-induced
T7489 10698-10703 Protein denotes IFNα4
T7488 14768-14773 Protein denotes NF-κB
T7487 10111-10116 Protein denotes RIG-I
T7486 10209-10213 Protein denotes IRF7
T7485 10088-10100 Entity denotes CARD domains
T7484 12607-12640 Entity denotes A20 deficient primary macrophages
T7483 14759-14762 Protein denotes TNF
T7482 13750-13759 Entity denotes poly(I:C)
T7481 12813-12819 Entity denotes exon V
T7480 10239-10243 Protein denotes IRF7
T7479 14582-14586 Protein denotes IRF3
T7478 12946-12954 Protein denotes lysozyme
T7477 12607-12610 Protein denotes A20
T7476 9997-10060 Protein denotes truncated constitutive active form of RIG-I [53], corresponding
T7475 10698-10712 Entity denotes IFNα4 promoter
T7474 14226-14232 Entity denotes serine
T7473 10233-10238 Protein denotes IRF3,
T7472 14245-14270 Protein denotes the IKK-like kinases TBK1
T7471 14942-14945 Protein denotes TNF
T7470 10581-10586 Protein denotes IFNα4
T7469 14346-14357 Entity denotes the nucleus
T7468 10298-10317 Protein denotes IRF7 protein levels
T7467 15158-15163 Protein denotes NF-κB
T7466 14142-14146 Protein denotes IRF3
T7465 9742-9755 Protein denotes expressed A20
T7464 15187-15206 Entity denotes primary macrophages
T7463 11039-11058 Protein denotes RIG-I-induced NF-κB
T7462 13306-13315 Protein denotes MDA5 [57]
T7461 13923-13942 Protein denotes of IκBα (figure 1B)
T7460 9917-9931 Protein denotes IRF3-dependent
T7459 14419-14440 Entity denotes phosphorylated Ser396
T7458 12872-12965 Protein denotes mice with transgenic mice expressing Cre recombinase under control of the lysozyme M promoter
T7457 12996-13009 Entity denotes myeloid cells
T7456 14950-14966 Protein denotes IFNβ (figure 1D)
T7455 13288-13293 Protein denotes RIG-I
T7454 14275-14284 Protein denotes IKKε [58]
T7453 12502-12510 Protein denotes on RIG-I
T7452 9861-9864 Protein denotes A20
T7451 10073-10087 Entity denotes two N-terminal
T7450 10661-10665 Protein denotes IRF7
T7449 13391-13395 Protein denotes TLR3
T7448 12909-12912 Protein denotes Cre
T7447 13802-13805 Protein denotes A20
T7446 14020-14052 Entity denotes poly(I:C) transfected A20myel-KO
T7445 9614-9639 Protein denotes proinflammatory cytokines
T7444 10889-10893 Protein denotes IRF3
T7443 13669-13672 Protein denotes A20
T7442 14577-14581 Protein denotes p65,
T7441 10413-10419 Protein denotes of A20
T7440 13986-13989 Protein denotes p65
T7439 9644-9695 Protein denotes type I IFNs that restrict further viral propagation
T7438 15086-15089 Protein denotes A20
T7437 10361-10365 Protein denotes IRF3
T7436 9443-9446 Protein denotes A20
T7435 10939-10943 Protein denotes IRF7
T7434 9538-9543 Protein denotes NF-κB
T7433 14750-14754 Protein denotes IL-6
T7432 9554-9558 Protein denotes IRF7
T7431 9480-9484 Protein denotes IRF3
T7430 14110-14140 Entity denotes to wild type cells (figure 1C)
T7429 14245-14270 Protein denotes the IKK-like kinases TBK1
T7428 10104-10109 Protein denotes RIG-I
T7427 10541-10554 Protein denotes RIG-I (2CARD)
T7426 14806-14813 Protein denotes of IFNβ
T7425 11068-11069 Protein denotes 7
T7424 12909-12924 Protein denotes Cre recombinase
T7423 13037-13081 Protein denotes myeloid cell specific A20 knockout mice [48]
T7422 14297-14313 Entity denotes its dimerization
T7421 13345-13357 Entity denotes of poly(I:C)
T7420 10298-10302 Protein denotes IRF7
T7419 13059-13062 Protein denotes A20
T7418 15141-15149 Protein denotes of RIG-I
T7417 13538-13544 Protein denotes of A20
T7416 14855-14860 Protein denotes NF-κB
T7415 13704-13707 Protein denotes A20
T7414 15168-15172 Protein denotes IRF3
T7413 13100-13105 Protein denotes RIG-I
T7412 11063-11069 Protein denotes IRF3/7
T7411 12939-12965 Entity denotes of the lysozyme M promoter
T7410 11039-11052 Protein denotes RIG-I-induced
T7409 10876-10884 Protein denotes on NF-κB
T7408 12648-12670 Protein denotes A20 full knockout mice
T7407 13096-13115 Protein denotes the RIG-I receptor,
T7406 13037-13058 Entity denotes myeloid cell specific
T7405 11021-11027 Protein denotes of A20
T7404 9932-9942 Protein denotes luciferase
T7403 12806-12808 Protein denotes IV
T7402 9777-9782 Protein denotes NF-κB
T7401 14717-14722 Protein denotes NF-κB
T7400 12648-12651 Protein denotes A20
T7399 13979-14003 Protein denotes of the p65 NF-κB subunit
T7398 13486-13495 Entity denotes poly(I:C)
T7397 12753-12855 Protein denotes mice carrying a conditional A20 allele in which exon IV and exon V were flanked by two loxP sites [56]
T7396 10564-10606 Protein denotes an IRF7-specific IFNα4 luciferase reporter
T7395 14936-14940 Protein denotes IL-6
T7394 10567-10580 Protein denotes IRF7-specific
T7393 9496-9501 Protein denotes RIG-I
T7392 12472-12501 Protein denotes of endogenously expressed A20
T7391 12833-12855 Entity denotes by two loxP sites [56]
T7544 12452-12510 Regulation denotes To study the effect of endogenously expressed A20 on RIG-I
T7543 14717-14762 Regulation denotes NF-κB controls the expression of IL-6 and TNF
T7542 14717-14762 Regulation denotes NF-κB controls the expression of IL-6 and TNF
T7541 10347-10387 Positive_regulation denotes virus-induced IRF3 activation [54], [55]
T7540 10209-10224 Positive_regulation denotes IRF7 activation
T7539 13252-13315 Positive_regulation denotes to preferentially bind and activate RIG-I rather than MDA5 [57]
T7538 12472-12501 Gene_expression denotes of endogenously expressed A20
T7537 10479-10508 Gene_expression denotes of an IRF7 expression plasmid
T7536 15168-15183 Positive_regulation denotes IRF3 activation
T7535 14791-14813 Gene_expression denotes the expression of IFNβ
T7534 10191-10224 Negative_regulation denotes A20 also inhibits IRF7 activation
T7533 9808-9830 Positive_regulation denotes RIG-I stimulation [50]
T7532 10925-10979 Positive_regulation denotes RIG-I-induced IRF7 activation (figure 1A, right graph)
T7531 10906-10979 Negative_regulation denotes A20 also prevented RIG-I-induced IRF7 activation (figure 1A, right graph)
T7530 14768-14813 Regulation denotes NF-κB and IRF3 control the expression of IFNβ
T7529 14768-14813 Regulation denotes NF-κB and IRF3 control the expression of IFNβ
T7528 13517-13544 Gene_expression denotes the rapid expression of A20
T4360 5717-5732 Binding denotes ligand binding,
T4359 3620-3654 Localization denotes by specific intracellular PRRs [3]
T4358 6602-6615 Positive_regulation denotes RLR signaling
T4357 6519-6677 Regulation denotes DUBA [28], CYLD [29], [30] and OTUB1/2 [31] have been shown to negatively regulate RLR signaling by specifically removing K63-linked polyubiquitin chains from
T4356 9144-9165 Gene_expression denotes chemokine production,
T4355 6419-6434 Positive_regulation denotes IRF3 activation
T4354 6865-6909 Negative_regulation denotes thus inhibiting further downstream signaling
T4353 4324-4364 Gene_expression denotes the production of antiviral proteins [9]
T4352 9097-9139 Binding denotes mice is associated with increased cytokine
T4351 6800-6864 Regulation denotes respectively MAVS and TRAF3 for proteasome mediated degradation,
T4350 6800-6864 Regulation denotes respectively MAVS and TRAF3 for proteasome mediated degradation,
T4349 3178-3196 Positive_regulation denotes Triggering of PRRs
T4348 5213-5227 Regulation denotes RIG-I mediated
T4347 6440-6457 Positive_regulation denotes RIG-I stimulation
T4346 6280-6296 Positive_regulation denotes RIG-I activation
T4345 5210-5242 Positive_regulation denotes on RIG-I mediated signaling [13]
T4344 7732-7776 Localization denotes gene targeting of A20 in specific cell types
T4343 3620-3654 Protein denotes by specific intracellular PRRs [3]
T4342 3994-4035 Entity denotes the PYHIN domain containing proteins AIM2
T4341 6330-6339 Entity denotes ubiquitin
T4340 6530-6545 Protein denotes CYLD [29], [30]
T4339 7062-7067 Protein denotes RBCK1
T4338 3461-3474 Protein denotes IRF7 [1], [2]
T4337 6741-6767 Protein denotes ubiquitin ligases, such as
T4336 6977-7025 Protein denotes to the IRF3 and IRF7 transcription factors by E3
T4335 3010-3019 Entity denotes antiviral
T4334 3452-3456 Protein denotes IRF3
T4333 7120-7123 Protein denotes A20
T4332 6519-6528 Protein denotes DUBA [28]
T4331 6822-6842 Protein denotes TRAF3 for proteasome
T4330 5596-5635 Entity denotes a C-terminal DExD/H box helicase domain
T4329 3656-3685 Protein denotes Endosomal Toll-like receptors
T4328 6377-6387 Protein denotes TRAF3 [27]
T4327 5940-5954 Entity denotes its C-terminal
T4326 6782-6794 Protein denotes TRIAD3A [33]
T4325 5683-5697 Entity denotes two N-terminal
T4324 9234-9255 Entity denotes alveolar macrophages,
T4323 9198-9218 Entity denotes immune cells such as
T4322 6311-6372 Protein denotes well characterized ubiquitin ligases such as TRAF6 [25], [26]
T4321 3837-3841 Protein denotes Nod2
T4320 3728-3742 Protein denotes like receptors
T4319 8948-8952 Protein denotes mice
T4318 6832-6842 Entity denotes proteasome
T4317 6440-6445 Protein denotes RIG-I
T4316 7747-7753 Protein denotes of A20
T4315 3446-3450 Protein denotes AP-1
T4314 5822-5826 Protein denotes VISA
T4313 6696-6705 Entity denotes molecules
T4312 4308-4311 Entity denotes DNA
T4311 4149-4183 Entity denotes plasmacytoid dendritic cells (pDC)
T4310 3982-3989 Protein denotes DAI [4]
T4309 7214-7217 Protein denotes A20
T4308 7193-7197 Protein denotes DUBs
T4307 8651-8672 Entity denotes myeloid cell specific
T4306 3102-3105 Protein denotes PRR
T4305 4300-4303 Protein denotes RNA
T4304 7262-7274 Entity denotes K48-specific
T4303 5069-5083 Protein denotes Both receptors
T4302 8909-8920 Entity denotes macrophages
T4301 8463-8466 Protein denotes A20
T4300 5793-5851 Protein denotes the MAVS (also termed IPS-1, VISA, Cardif) adaptor protein
T4299 6504-6508 Protein denotes DUBs
T4298 3753-3778 Protein denotes Nod-like receptors (NLRs)
T4297 6122-6127 Protein denotes RIG-I
T4296 5259-5264 Protein denotes RIG-I
T4295 7288-7294 Protein denotes ligase
T4294 8886-8895 Entity denotes antiviral
T4293 3521-3530 Protein denotes viral RNA
T4292 6943-6955 Entity denotes K48-specific
T4291 3862-3885 Protein denotes RNA (TLR3, RIG-I, MDA5)
T4290 8480-8486 Protein denotes RIG-I-
T4289 9041-9058 Protein denotes to wild type mice
T4288 6047-6056 Protein denotes ubiquitin
T4287 6163-6175 Entity denotes K63-specific
T4286 7516-7526 Protein denotes TLR4 [40],
T4285 6641-6651 Entity denotes K63-linked
T4284 9369-9372 Protein denotes A20
T4283 6652-6665 Protein denotes polyubiquitin
T4282 7570-7576 Protein denotes of A20
T4281 4054-4063 Protein denotes IFI16 [8]
T4280 5903-5935 Entity denotes the outer mitochondrial membrane
T4279 5620-5628 Protein denotes helicase
T4278 3825-3830 Protein denotes TLR7,
T4277 4247-4258 Entity denotes macrophages
T4276 3994-4035 Protein denotes the PYHIN domain containing proteins AIM2
T4275 9097-9101 Protein denotes mice
T4274 9116-9139 Protein denotes with increased cytokine
T4273 3304-3324 Protein denotes interferon-α (IFN-α)
T4272 3265-3269 Protein denotes IL-6
T4271 7168-7175 Protein denotes the OTU
T4270 7035-7044 Protein denotes RAUL [34]
T4269 8527-8532 Protein denotes IRF-3
T4268 4956-4992 Entity denotes an intermediate of viral replication
T4267 3926-3952 Entity denotes antiviral immune responses
T4266 7089-7098 Entity denotes antiviral
T4265 8651-8690 Protein denotes myeloid cell specific A20 knockout mice
T4264 6340-6355 Protein denotes ligases such as
T4263 6602-6605 Protein denotes RLR
T4262 7240-7244 Entity denotes zinc
T4261 3189-3196 Protein denotes of PRRs
T4260 5683-5710 Entity denotes two N-terminal CARD domains
T4259 5717-5723 Entity denotes ligand
T4258 5742-5758 Entity denotes domains of RIG-I
T4257 7732-7736 Protein denotes gene
T4256 8267-8273 Protein denotes of A20
T4255 4224-4245 Protein denotes conventional DC (cDC)
T4254 3045-3107 Protein denotes the action of specialized pattern recognition receptors (PRR),
T4253 3632-3645 Entity denotes intracellular
T4252 3535-3605 Entity denotes DNA, viral replication intermediates and viral transcription products,
T4251 4886-4913 Protein denotes single-stranded genomic RNA
T4250 4869-4938 Entity denotes the host cell of single-stranded genomic RNA and double stranded RNA,
T4249 4703-4712 Entity denotes antiviral
T4248 3773-3777 Protein denotes NLRs
T4247 8292-8321 Entity denotes of antiviral immune responses
T4246 5659-5665 Entity denotes ligand
T4245 3722-3749 Protein denotes RIG-I-like receptors (RLRs)
T4244 8673-8676 Protein denotes A20
T4243 6280-6285 Protein denotes RIG-I
T4242 4179-4182 Protein denotes pDC
T4241 5213-5227 Protein denotes RIG-I mediated
T4240 3274-3278 Protein denotes IL-1
T4239 4133-4184 Protein denotes I IFN producing plasmacytoid dendritic cells (pDC),
T4238 5815-5827 Protein denotes IPS-1, VISA,
T4237 7463-7509 Protein denotes multiple receptors such as TNF receptor I [37]
T4236 6209-6220 Protein denotes TRIM25 [22]
T4235 7463-7489 Protein denotes multiple receptors such as
T4234 9385-9398 Entity denotes myeloid cells
T4233 7884-7887 Protein denotes A20
T4232 5596-5635 Entity denotes a C-terminal DExD/H box helicase domain
T4231 3753-3778 Protein denotes Nod-like receptors (NLRs)
T4230 6176-6185 Protein denotes ubiquitin
T4229 3976-3980 Protein denotes TLR9
T4228 5815-5834 Protein denotes IPS-1, VISA, Cardif
T4227 5330-5334 Protein denotes TLR3
T4226 5581-5586 Protein denotes RIG-I
T4225 7127-7182 Entity denotes an ubiquitin-editing enzyme belonging to the OTU-domain
T4224 9144-9153 Protein denotes chemokine
T4223 3722-3749 Protein denotes RIG-I-like receptors (RLRs)
T4222 8491-8503 Protein denotes TLR3-induced
T4221 4342-4351 Entity denotes antiviral
T4220 2932-2948 Entity denotes on the host cell
T4219 3439-3444 Protein denotes NF-κB
T4218 5753-5758 Protein denotes RIG-I
T4217 3260-3263 Protein denotes TNF
T4216 4185-4206 Entity denotes while most other cell
T4215 4263-4274 Entity denotes fibroblasts
T4214 3956-3959 Entity denotes DNA
T4213 6813-6817 Protein denotes MAVS
T4212 3867-3884 Protein denotes TLR3, RIG-I, MDA5
T4211 5330-5349 Protein denotes TLR3 deficient mice
T4210 4994-4998 Protein denotes TLR3
T4209 5596-5635 Entity denotes a C-terminal DExD/H box helicase domain
T4208 7531-7536 Protein denotes IL-1R
T4207 3244-3279 Protein denotes cytokines (e.g. TNF, IL-6 and IL-1)
T4206 3867-3879 Protein denotes TLR3, RIG-I,
T4205 6550-6562 Protein denotes OTUB1/2 [31]
T4204 7543-7576 Entity denotes The anti-inflammatory role of A20
T4171 6011-6015 Protein denotes MAVS
T4170 7231-7287 Protein denotes atypical zinc finger dependent K48-specific E3 ubiquitin
T4169 3329-3334 Protein denotes IFN-β
T4168 3825-3842 Protein denotes TLR7, TLR8, Nod2)
T4167 8071-8074 Protein denotes A20
T4166 5003-5008 Protein denotes RIG-I
T4165 3901-3904 Entity denotes DNA
T4164 7618-7636 Protein denotes A20 deficient mice
T4163 7757-7776 Entity denotes specific cell types
T4162 6163-6193 Protein denotes K63-specific ubiquitin ligases
T4161 6984-6988 Protein denotes IRF3
T4203 6419-6423 Protein denotes IRF3
T4202 8517-8522 Protein denotes NF-κB
T4201 7148-7154 Protein denotes enzyme
T4200 7444-7447 Protein denotes A20
T4199 3744-3748 Protein denotes RLRs
T4198 4241-4244 Entity denotes cDC
T4197 3887-3967 Entity denotes Intracellular DNA sensors that mediate antiviral immune responses to DNA viruses
T4196 6728-6740 Entity denotes K48-specific
T4195 5154-5193 Entity denotes of the innate antiviral immune response
T4194 4339-4360 Protein denotes of antiviral proteins
T4193 6993-6997 Protein denotes IRF7
T4192 3757-3771 Protein denotes like receptors
T4191 6036-6075 Protein denotes of various ubiquitin modifying enzymes,
T4190 3873-3878 Protein denotes RIG-I
T4189 6741-6750 Protein denotes ubiquitin
T4188 3994-4035 Protein denotes the PYHIN domain containing proteins AIM2
T4187 6225-6231 Protein denotes Riplet
T4186 5507-5522 Entity denotes by immune cells
T4185 3291-3335 Protein denotes interferons (interferon-α (IFN-α) and IFN-β)
T4184 3697-3801 Protein denotes cytoplasmic RNA helicase RIG-I-like receptors (RLRs) or Nod-like receptors (NLRs) detect the presence of
T4183 6768-6777 Protein denotes AIP4 [32]
T4182 3318-3323 Protein denotes IFN-α
T4181 8815-8818 Protein denotes A20
T4180 5259-5279 Protein denotes RIG-I deficient mice
T4179 6409-6414 Protein denotes NF-κB
T4178 7046-7057 Protein denotes TRIM21 [35]
T4177 3489-3512 Entity denotes of viral nucleic acids,
T4176 6956-6969 Protein denotes polyubiquitin
T4175 5769-5789 Entity denotes with the CARD domain
T4174 5797-5835 Protein denotes MAVS (also termed IPS-1, VISA, Cardif)
T4173 8578-8584 Protein denotes of A20
T4172 7618-7621 Protein denotes A20
T655 1512-1529 Negative_regulation denotes inhibition of A20
T654 992-1109 Positive_regulation denotes IRF3 activation, concomitant with increased production of proinflammatory cytokines, chemokines and type I interferon
T653 795-864 Gene_expression denotes editing protein A20 in the response of myeloid cells to IAV infection
T652 973-987 Positive_regulation denotes enhanced NF-κB
T651 481-549 Gene_expression denotes the production of proinflammatory cytokines and antiviral interferon
T650 481-549 Gene_expression denotes the production of proinflammatory cytokines and antiviral interferon
T649 415-469 Localization denotes the intracellular pathogen recognition receptor RIG-I
T648 1026-1109 Positive_regulation denotes increased production of proinflammatory cytokines, chemokines and type I interferon
T647 1217-1237 Regulation denotes of IAV infected mice
T646 992-996 Protein denotes IRF3
T643 718-757 Protein denotes myeloid cell specific A20 knockout mice
T642 415-468 Protein denotes the intracellular pathogen recognition receptor RIG-I
T641 1275-1278 Protein denotes A20
T640 348-363 Entity denotes an intermediate
T630 1077-1087 Protein denotes chemokines
T631 325-344 Protein denotes double-stranded RNA
T632 1217-1237 Protein denotes of IAV infected mice
T621 0-13 Protein denotes A20 (Tnfaip3)
T615 499-524 Protein denotes proinflammatory cytokines
T616 1167-1187 Entity denotes alveolar macrophages
T617 803-814 Protein denotes protein A20
T618 834-847 Entity denotes myeloid cells
T619 973-987 Protein denotes enhanced NF-κB
T620 778-794 Protein denotes of the ubiquitin
T622 1253-1292 Protein denotes myeloid cell specific A20 knockout mice
T623 529-538 Entity denotes antiviral
T624 740-743 Protein denotes A20
T625 866-869 Protein denotes A20
T626 718-739 Entity denotes myeloid cell specific
T627 803-814 Protein denotes protein A20
T628 529-549 Protein denotes antiviral interferon
T629 259-290 Entity denotes to specific microbial molecules
T633 1253-1274 Entity denotes myeloid cell specific
T634 415-468 Protein denotes the intracellular pathogen recognition receptor RIG-I
T635 1192-1203 Entity denotes neutrophils
T636 1050-1075 Protein denotes proinflammatory cytokines
T637 419-432 Entity denotes intracellular
T638 1523-1529 Protein denotes of A20
T639 866-891 Entity denotes A20 deficient macrophages
R3108 T4253 T4359 locationOf intracellular,by specific intracellular PRRs [3]
R3109 T4343 T4359 themeOf by specific intracellular PRRs [3],by specific intracellular PRRs [3]
R3111 T4263 T4358 causeOf RLR,RLR signaling
R3112 T4358 T4357 themeOf RLR signaling,"DUBA [28], CYLD [29], [30] and OTUB1/2 [31] have been shown to negatively regulate RLR signaling by specifically removing K63-linked polyubiquitin chains from"
R5324 T7401 T7542 causeOf NF-κB,NF-κB controls the expression of IL-6 and TNF
R5325 T7401 T7543 causeOf NF-κB,NF-κB controls the expression of IL-6 and TNF
R5326 T7407 T7550 themeOf "the RIG-I receptor,","To stimulate the RIG-I receptor,"
R5327 T7412 T7561 themeOf IRF3/7,IRF3/7 activation
R5328 T7392 T7538 themeOf of endogenously expressed A20,of endogenously expressed A20
R5329 T7392 T7544 causeOf of endogenously expressed A20,To study the effect of endogenously expressed A20 on RIG-I
R5330 T7393 T7565 causeOf RIG-I,RIG-I signaling
R5331 T7414 T7536 themeOf IRF3,IRF3 activation
R5332 T7416 T7564 themeOf NF-κB,the enhanced activation of NF-κB and IRF3
R5333 T7504 T7534 causeOf A20,A20 also inhibits IRF7 activation
R5334 T7417 T7528 themeOf of A20,the rapid expression of A20
R5335 T7506 T7531 causeOf A20,"A20 also prevented RIG-I-induced IRF7 activation (figure 1A, right graph)"
R5336 T7418 T7559 themeOf of RIG-I,regulation of RIG-I
R5337 T7510 T7562 themeOf IRF3,IRF3 activation
R5338 T7424 T7568 themeOf Cre recombinase,mice with transgenic mice expressing Cre recombinase under control of the lysozyme M promoter
R5339 T7511 T7545 themeOf IRF3,IRF3 activation
R5340 T7512 T7563 themeOf IRF3,the enhanced activation of NF-κB and IRF3
R5341 T7514 T7537 themeOf IRF7,of an IRF7 expression plasmid
R5342 T7515 T7529 causeOf IRF3,NF-κB and IRF3 control the expression of IFNβ
R5343 T7516 T7551 themeOf NF-κB-,we show that A20 overexpression in HEK293T cells prevents NF-κB-
R5344 T7516 T7552 themeOf NF-κB-,we show that A20 overexpression in HEK293T cells prevents NF-κB-
R5345 T7518 T7548 themeOf IRF3,maximum IRF3 phosphorylation
R5346 T7521 T7533 themeOf RIG-I,RIG-I stimulation [50]
R5347 T7425 T7560 themeOf 7,IRF3/7 activation
R5348 T7525 T7549 themeOf on IRF7 activation,"To determine the effect of A20 on IRF7 activation,"
R5349 T7426 T7535 themeOf of IFNβ,the expression of IFNβ
R5350 T7431 T7524 themeOf IRF3,IRF3 activation
R5351 T7532 T7531 themeOf "RIG-I-induced IRF7 activation (figure 1A, right graph)","A20 also prevented RIG-I-induced IRF7 activation (figure 1A, right graph)"
R5352 T7535 T7529 themeOf the expression of IFNβ,NF-κB and IRF3 control the expression of IFNβ
R5353 T7535 T7530 themeOf the expression of IFNβ,NF-κB and IRF3 control the expression of IFNβ
R5354 T7433 T7546 themeOf IL-6,the expression of IL-6 and TNF
R5355 T7435 T7532 themeOf IRF7,"RIG-I-induced IRF7 activation (figure 1A, right graph)"
R5356 T7540 T7534 themeOf IRF7 activation,A20 also inhibits IRF7 activation
R5357 T7437 T7541 themeOf IRF3,"virus-induced IRF3 activation [54], [55]"
R5358 T7546 T7542 themeOf the expression of IL-6 and TNF,NF-κB controls the expression of IL-6 and TNF
R5359 T7547 T7543 themeOf the expression of IL-6 and TNF,NF-κB controls the expression of IL-6 and TNF
R5360 T7439 T7566 themeOf type I IFNs that restrict further viral propagation,the expression of proinflammatory cytokines and type I IFNs that restrict further viral propagation
R5361 T7441 T7549 causeOf of A20,"To determine the effect of A20 on IRF7 activation,"
R5362 T7554 T7551 causeOf A20 overexpression,we show that A20 overexpression in HEK293T cells prevents NF-κB-
R5363 T7444 T7558 themeOf IRF3,"IRF3 activation,"
R5364 T7555 T7552 causeOf A20 overexpression,we show that A20 overexpression in HEK293T cells prevents NF-κB-
R5365 T7445 T7567 themeOf proinflammatory cytokines,the expression of proinflammatory cytokines and type I IFNs that restrict further viral propagation
R5366 T7450 T7526 themeOf IRF7,of IRF7 co-expression
R5367 T7563 T7570 themeOf the enhanced activation of NF-κB and IRF3,the enhanced activation of NF-κB and IRF3
R5368 T7564 T7569 themeOf the enhanced activation of NF-κB and IRF3,the enhanced activation of NF-κB and IRF3
R5369 T7566 T7557 themeOf the expression of proinflammatory cytokines and type I IFNs that restrict further viral propagation,which promote the expression of proinflammatory cytokines and type I IFNs that restrict further viral propagation
R5370 T7567 T7556 themeOf the expression of proinflammatory cytokines and type I IFNs that restrict further viral propagation,which promote the expression of proinflammatory cytokines and type I IFNs that restrict further viral propagation
R5371 T7452 T7554 themeOf A20,A20 overexpression
R5372 T7452 T7555 themeOf A20,A20 overexpression
R5373 T7453 T7544 themeOf on RIG-I,To study the effect of endogenously expressed A20 on RIG-I
R5374 T7455 T7539 themeOf RIG-I,to preferentially bind and activate RIG-I rather than MDA5 [57]
R5375 T7461 T7553 themeOf of IκBα (figure 1B),sustained degradation of IκBα (figure 1B)
R5376 T7483 T7547 themeOf TNF,the expression of IL-6 and TNF
R5377 T7486 T7540 themeOf IRF7,IRF7 activation
R5378 T7488 T7530 causeOf NF-κB,NF-κB and IRF3 control the expression of IFNβ
R5379 T7497 T7523 themeOf enhanced NF-κB activation,enhanced NF-κB activation
R5380 T7498 T7525 themeOf IRF7,on IRF7 activation
R6075 T8514 T8553 themeOf on RIG-I-induced NF-κB,with the inhibitory effect of A20 seen on RIG-I-induced NF-κB
R6076 T8514 T8554 themeOf on RIG-I-induced NF-κB,on RIG-I-induced NF-κB
R6077 T8514 T8555 themeOf on RIG-I-induced NF-κB,on RIG-I-induced NF-κB
R6078 T8526 T8553 causeOf of A20,with the inhibitory effect of A20 seen on RIG-I-induced NF-κB
R6079 T8531 T8552 causeOf A20,A20 directly controls IAV-induced gene expression in alveolar macrophages
R6080 T8532 T8557 themeOf IL-6,expression of IL-6 and IFNβ mRNA
R6081 T8533 T8554 causeOf RIG-I-induced,on RIG-I-induced NF-κB
R6082 T8536 T8556 themeOf IFNβ mRNA,expression of IL-6 and IFNβ mRNA
R8464 T11447 T11502 themeOf MIP-2,MIP-2 production
R10921 T14598 T14750 themeOf TBK1,K63-polyubiquitination of TBK1 and IKKε
R10922 T14600 T14763 themeOf MIP-2,neutrophil attracting chemokines such as KC and MIP-2
R10924 T14604 T14761 themeOf MCP-1,of MCP-1 production
R10928 T14612 T14730 themeOf IRF3,IRF3 activation
R10929 T14614 T14743 themeOf A20,A20 expression
R10930 T14621 T14741 themeOf IRF3,IRF3 activation
R10932 T14655 T14731 themeOf NF-κB,NF-κB activation
R10933 T14629 T14745 causeOf of different signaling proteins [80],of different signaling proteins [80]
R10934 T14640 T14742 causeOf RIG-I,RIG-I signaling
R10935 T14661 T14762 themeOf chemokines such as KC,neutrophil attracting chemokines such as KC and MIP-2
R10936 T14645 T14749 themeOf IKKε,K63-polyubiquitination of TBK1 and IKKε
R10937 T14662 T14740 causeOf A20,that A20 inhibits IAV-induced proinflammatory gene expression
R10938 T14666 T14748 themeOf TRAF3-TBK1-IKKε,disrupt the TRAF3-TBK1-IKKε
R10939 T14673 T14739 themeOf ABIN1 to to disrupt the TRAF3-TBK1-IKKε complex,ABIN1 to to disrupt the TRAF3-TBK1-IKKε complex
R10940 T14749 T14753 themeOf K63-polyubiquitination of TBK1 and IKKε,thereby negatively affecting K63-polyubiquitination of TBK1 and IKKε
R10941 T14750 T14754 themeOf K63-polyubiquitination of TBK1 and IKKε,thereby negatively affecting K63-polyubiquitination of TBK1 and IKKε
R10942 T14678 T14758 themeOf IL-1β in the lungs of A20myel-KO mice compared to wild type mice,IL-1β in the lungs of A20myel-KO mice compared to wild type mice
R10943 T14682 T14757 themeOf binding proteins,binding proteins
R10944 T14694 T14756 themeOf IKKε,"to clearly detect ubiquitination of TBK1 and IKKε in primary macrophages, preventing us from studying the effect of A20"
R10945 T14695 T14759 themeOf of RIG-I,in the regulation of RIG-I induced
R10946 T14696 T14736 causeOf RIG-I,enhanced RIG-I signaling
R10947 T14697 T14733 themeOf RIG-I,RIG-I stimulation
R10948 T14699 T14732 themeOf these genes,the major pathways controlling these genes
R10949 T14701 T14598 partOf K63,TBK1
R10950 T14701 T14645 partOf K63,IKKε
R10951 T14701 T14749 siteOf K63,K63-polyubiquitination of TBK1 and IKKε
R10952 T14701 T14750 siteOf K63,K63-polyubiquitination of TBK1 and IKKε
R10953 T14702 T14746 themeOf TBK1,disrupt the TRAF3-TBK1-IKKε
R10954 T14705 T14738 causeOf RIG-I induced,RIG-I induced signaling
R10955 T14705 T14751 themeOf RIG-I induced,RIG-I induced
R10956 T14705 T14752 themeOf RIG-I induced,RIG-I induced
R10957 T14707 T14734 themeOf IRF3,"IRF3 activation,"
R10958 T14718 T14760 themeOf A20,A20 expression in myeloid cells
R10959 T14719 T14755 themeOf TBK1,"to clearly detect ubiquitination of TBK1 and IKKε in primary macrophages, preventing us from studying the effect of A20"
R10960 T14725 T14747 themeOf TRAF3,disrupt the TRAF3-TBK1-IKKε
R10961 T14736 T14735 themeOf enhanced RIG-I signaling,enhanced RIG-I signaling
R11390 T15258 T15275 themeOf A20fl/fl LysMCre transgenes,to generate A20fl/fl LysMCre transgenes
R11391 T15268 T15276 themeOf A20fl/fl mice expressing or lacking the LysM-Cre transgene,A20fl/fl mice expressing or lacking the LysM-Cre transgene
R11392 T15269 T15277 themeOf individually ventilated cages,individually ventilated cages
R12116 T16055 T16070 themeOf proteins,To remove sialic acid binding proteins
R12423 T16516 T16523 themeOf the mice,treating the mice intranasally
R14348 T19081 T19092 themeOf Total RNA,Total RNA was extracted using Aurum Total RNA mini kit (BioRad)
R15131 T20194 T20222 themeOf IκBα,IκBα phosphorylation
R15132 T20204 T20220 themeOf IRF3,IRF3 activation
R15133 T20208 T20223 themeOf RIG-I,RIG-I stimulation
R15134 T20212 T20221 themeOf IRF3,IRF3 phosphorylation by immunoblotting
R15493 T20741 T20746 themeOf IL-6 and IFNβ mRNA,IL-6 and IFNβ mRNA expression was determined by qPCR (C)
R15494 T20741 T20747 themeOf IL-6 and IFNβ mRNA,IL-6 and IFNβ mRNA expression was determined by qPCR (C)
R15495 T20743 T20750 causeOf A20,A20 negatively regulates IAV-induced gene expression in BMDM and alveolar macrophages
R15496 T20744 T20748 themeOf "IL-6, IFNβ and A20 mRNA","IL-6, IFNβ and A20 mRNA expression was analyzed by qPCR"
R15497 T20744 T20749 themeOf "IL-6, IFNβ and A20 mRNA","IL-6, IFNβ and A20 mRNA expression was analyzed by qPCR"
R15841 T21177 T21191 themeOf from IAV infected mice,from IAV infected mice
R510 T615 T651 themeOf proinflammatory cytokines,the production of proinflammatory cytokines and antiviral interferon
R511 T617 T653 themeOf protein A20,editing protein A20 in the response of myeloid cells to IAV infection
R512 T619 T652 themeOf enhanced NF-κB,enhanced NF-κB
R513 T628 T650 themeOf antiviral interferon,the production of proinflammatory cytokines and antiviral interferon
R514 T632 T647 themeOf of IAV infected mice,of IAV infected mice
R515 T634 T649 themeOf the intracellular pathogen recognition receptor RIG-I,the intracellular pathogen recognition receptor RIG-I
R481 T646 T654 themeOf IRF3,"IRF3 activation, concomitant with increased production of proinflammatory cytokines, chemokines and type I interferon"
R516 T637 T649 locationOf intracellular,the intracellular pathogen recognition receptor RIG-I
R517 T638 T655 themeOf of A20,inhibition of A20
R3092 T4163 T4344 locationOf specific cell types,gene targeting of A20 in specific cell types
R3098 T4203 T4355 themeOf IRF3,IRF3 activation
R3099 T4213 T4350 causeOf MAVS,"respectively MAVS and TRAF3 for proteasome mediated degradation,"
R3100 T4194 T4353 themeOf of antiviral proteins,the production of antiviral proteins [9]
R3101 T4224 T4356 themeOf chemokine,"chemokine production,"
R3102 T4241 T4345 causeOf RIG-I mediated,on RIG-I mediated signaling [13]
R3103 T4316 T4344 themeOf of A20,gene targeting of A20 in specific cell types
R3104 T4317 T4347 themeOf RIG-I,RIG-I stimulation
R3105 T4331 T4351 causeOf TRAF3 for proteasome,"respectively MAVS and TRAF3 for proteasome mediated degradation,"
R3106 T4241 T4348 themeOf RIG-I mediated,RIG-I mediated
R3107 T4243 T4346 themeOf RIG-I,RIG-I activation
R3110 T4261 T4349 themeOf of PRRs,Triggering of PRRs
R3113 T4274 T4352 themeOf with increased cytokine,mice is associated with increased cytokine
R3114 T4275 T4352 themeOf mice,mice is associated with increased cytokine
R6083 T8551 T8558 themeOf IRF3,IRF3 activation
R8453 T11476 T11508 themeOf A20,by A20 expression in myeloid cells
R8455 T11390 T11510 themeOf of MCP-1,with the equal expression of MCP-1 in both groups of mice
R8456 T11483 T11506 themeOf to IAV infected wild type mice (figure 3C),to IAV infected wild type mice (figure 3C)
R8457 T11507 T11513 themeOf "in monocyte (CD11b+ Ly6C+) recruitment at day 4 post infection,","we could detect a significant increase in monocyte (CD11b+ Ly6C+) recruitment at day 4 post infection,"
R8458 T11407 T11503 themeOf IFNγ,IFNγ expression levels in the lungs
R8459 T11422 T11501 themeOf A20,of A20 expression
R8460 T11423 T11509 themeOf MCP-1,MCP-1 production
R8461 T11425 T11514 themeOf mock infected mice (figure 3D),mock infected mice (figure 3D)
R8462 T11509 T11512 themeOf MCP-1 production,MCP-1 production was not increased
R8463 T11446 T11504 themeOf IFNα,IFNα production

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T312 71-76 NNP denotes Virus
T313 77-86 NNP denotes Infection
T14245 32012-32014 VB denotes be
T21141 19788-19789 . denotes .
T21140 19784-19788 CD denotes 0.01
T21139 19783-19784 FW denotes <
T21138 19782-19783 FW denotes p
T21137 19780-19782 SYM denotes **
T21136 19778-19779 : denotes ;
T21135 19774-19778 CD denotes 0.05
T21134 19773-19774 NN denotes <
T21133 19772-19773 NN denotes p
T21132 19771-19772 SYM denotes *
T21131 19769-19770 . denotes .
T21130 19758-19769 NNS denotes experiments
T21129 19746-19757 JJ denotes independent
T21128 19744-19745 CD denotes 2
T21127 19741-19743 IN denotes of
T21126 19726-19740 NN denotes representative
T21125 19722-19725 VBP denotes are
T21124 19718-19721 CC denotes and
T21123 19712-19717 NN denotes group
T21122 19708-19711 IN denotes per
T21121 19703-19707 NNS denotes mice
T21120 19701-19702 CD denotes 5
T21119 19695-19700 JJS denotes least
T21118 19692-19694 IN denotes at
T21117 19689-19691 IN denotes of
T21116 19685-19688 NNP denotes SEM
T21115 19683-19684 CD denotes −
T21114 19682-19683 CD denotes /
T21113 19681-19682 VBP denotes +
T21112 19672-19680 NNS denotes averages
T21111 19668-19671 VBP denotes are
T21110 19660-19667 NNS denotes Numbers
T21109 19658-19659 . denotes .
T21108 19657-19658 -RRB- denotes )
T21107 19656-19657 NNP denotes D
T21106 19655-19656 -LRB- denotes (
T21105 19650-19654 VBP denotes p.i.
T21104 19645-19649 NNS denotes days
T21103 19642-19644 CD denotes 10
T21102 19638-19641 CC denotes and
T21101 19636-19637 CD denotes 7
T21100 19634-19635 , denotes ,
T21099 19633-19634 CD denotes 4
T21098 19630-19632 IN denotes at
T21097 19620-19629 NN denotes cytometry
T21096 19615-19619 NN denotes flow
T21095 19612-19614 IN denotes by
T21094 19603-19611 VBN denotes analyzed
T21093 19598-19602 VBD denotes were
T21092 19594-19597 NNP denotes BAL
T21091 19591-19593 IN denotes in
T21090 19581-19590 NNS denotes monocytes
T21089 19577-19580 CC denotes and
T21088 19565-19576 NNS denotes neutrophils
T21087 19563-19564 , denotes ,
T21086 19552-19563 NNS denotes macrophages
T21085 19543-19551 NN denotes alveolar
T21084 19534-19542 NN denotes resident
T21083 19531-19533 IN denotes of
T21082 19523-19530 NNS denotes numbers
T21081 19514-19522 JJ denotes Absolute
T21080 19512-19513 . denotes .
T21047 19362-19365 NNP denotes IAV
T21046 19357-19361 IN denotes from
T21045 19348-19356 VBN denotes isolated
T21044 19344-19347 VBD denotes was
T21043 19340-19343 NNP denotes BAL
T21042 19338-19339 . denotes .
T21041 19328-19338 JJ denotes detectable
T21040 19324-19327 RB denotes not
T21039 19322-19323 , denotes ,
T21038 19320-19322 NNP denotes ND
T21037 19318-19319 . denotes .
T21036 19313-19318 NN denotes limit
T20992 19119-19122 NNP denotes IAV
T20991 19116-19118 IN denotes of
T20990 19111-19115 NN denotes dose
T20989 19101-19110 JJ denotes sublethal
T20988 19099-19100 DT denotes a
T20987 19094-19098 IN denotes with
T20986 19081-19093 RB denotes intranasally
T20985 19072-19080 JJ denotes infected
T20984 19067-19071 VBD denotes were
T20983 19062-19066 NNS denotes mice
T20982 19051-19061 JJ denotes A20myel-KO
T20981 19047-19050 CC denotes and
T20980 19036-19046 NN denotes A20myel-WT
T20979 19034-19035 . denotes .
T20978 19025-19034 NN denotes infection
T20977 19020-19024 NN denotes lung
T21558 25394-25395 . denotes .
T21557 25389-25394 CD denotes 0.001
T21556 25388-25389 FW denotes <
T21555 25387-25388 FW denotes p
T21554 25384-25387 FW denotes ***
T21553 25382-25383 , denotes ,
T21552 25378-25382 CD denotes 0.01
T21551 25377-25378 FW denotes <
T21550 25376-25377 FW denotes p
T21549 25374-25376 SYM denotes **
T21548 25372-25373 : denotes ;
T21547 25368-25372 CD denotes 0.05
T21546 25367-25368 NN denotes <
T21545 25366-25367 NN denotes p
T21544 25365-25366 SYM denotes *
T21543 25363-25364 . denotes .
T21542 25352-25363 NNS denotes experiments
T21541 25340-25351 JJ denotes independent
T21540 25338-25339 CD denotes 2
T21539 25335-25337 IN denotes of
T21538 25320-25334 NN denotes representative
T21537 25316-25319 VBP denotes are
T21536 25311-25315 NNS denotes Data
T21535 25309-25310 . denotes .
T21534 25304-25309 NN denotes group
T21533 25300-25303 IN denotes per
T21532 25295-25299 NNS denotes mice
T21531 25293-25294 CD denotes 5
T21530 25287-25292 JJS denotes least
T21529 25284-25286 IN denotes at
T21528 25281-25283 IN denotes of
T21527 25277-25280 NNP denotes SEM
T21526 25275-25276 CD denotes −
T21525 25274-25275 CD denotes /
T21524 25273-25274 VBP denotes +
T21523 25264-25272 NNS denotes averages
T21522 25260-25263 VBP denotes are
T21521 25252-25259 NNS denotes Numbers
T21520 25250-25251 . denotes .
T21519 25249-25250 -RRB- denotes )
T21518 25248-25249 NNP denotes D
T21517 25247-25248 -LRB- denotes (
T21516 25242-25246 VBP denotes p.i.
T21515 25237-25241 NNS denotes days
T21514 25235-25236 CD denotes 6
T21513 25232-25234 IN denotes at
T21512 25222-25231 NN denotes cytometry
T21511 25217-25221 NN denotes flow
T21510 25214-25216 IN denotes by
T21509 25205-25213 VBN denotes analyzed
T21508 25200-25204 VBD denotes were
T21507 25196-25199 NNP denotes BAL
T21506 25193-25195 IN denotes in
T21505 25183-25192 NNS denotes monocytes
T21504 25179-25182 CC denotes and
T21503 25167-25178 NNS denotes neutrophils
T21502 25165-25166 , denotes ,
T21501 25154-25165 NNS denotes macrophages
T21500 25145-25153 JJ denotes alveolar
T21499 25142-25144 IN denotes of
T21498 25134-25141 NNS denotes numbers
T21497 25125-25133 JJ denotes Absolute
T21496 25123-25124 . denotes .
T21495 25122-25123 -RRB- denotes )
T21494 25121-25122 NNP denotes C
T21493 25120-25121 -LRB- denotes (
T21492 25109-25119 VBN denotes determined
T21491 25104-25108 VBD denotes were
T21490 25097-25103 NNS denotes levels
T21489 25089-25096 NN denotes protein
T21488 25084-25088 NNP denotes IFNα
T21487 25080-25083 CC denotes and
T21486 25075-25079 NNP denotes IL-6
T21485 25073-25074 , denotes ,
T21484 25068-25073 NNP denotes MCP-1
T21483 25066-25067 , denotes ,
T21482 25061-25066 NNP denotes MIP-2
T21481 25059-25060 , denotes ,
T21480 25057-25059 NNP denotes KC
T21479 25053-25056 CC denotes and
T21478 25049-25052 NNP denotes IAV
T21477 25044-25048 NN denotes dose
T21476 25037-25043 JJ denotes lethal
T21475 25035-25036 DT denotes a
T21474 25030-25034 IN denotes with
T21473 25020-25029 NN denotes infection
T21472 25010-25019 VBG denotes following
T21471 25005-25009 NNS denotes days
T21470 25003-25004 CD denotes 6
T21469 24998-25002 NNS denotes mice
T21468 24987-24997 JJ denotes A20myel-KO
T21467 24983-24986 CC denotes and
T21466 24981-24982 -RRB- denotes )
T21465 24971-24981 NN denotes A20myel-WT
T21464 24970-24971 -LRB- denotes (
T21463 24965-24969 NN denotes type
T21462 24960-24964 JJ denotes wild
T21461 24955-24959 IN denotes from
T21460 24945-24954 VBN denotes collected
T21459 24941-24944 VBD denotes was
T21458 24935-24940 NN denotes fluid
T21457 24931-24934 NNP denotes BAL
T21456 24926-24930 VBP denotes p.i.
T21455 24921-24925 NNS denotes days
T21454 24918-24920 CD denotes 15
T21453 24914-24917 CC denotes and
T21452 24911-24913 CD denotes 21
T21451 24898-24910 RB denotes respectively
T21450 24894-24897 IN denotes for
T21449 24884-24893 VBN denotes monitored
T21448 24880-24883 VBD denotes was
T21447 24878-24879 -RRB- denotes )
T21446 24877-24878 NNP denotes B
T21445 24876-24877 -LRB- denotes (
T21444 24872-24875 NNP denotes SEM
T21443 24870-24871 CD denotes −
T21442 24869-24870 CD denotes /
T21441 24868-24869 VBD denotes +
T21440 24863-24867 NN denotes loss
T21439 24856-24862 NN denotes weight
T21438 24852-24855 CC denotes and
T21437 24850-24851 -RRB- denotes )
T21436 24849-24850 NNP denotes A
T21435 24848-24849 -LRB- denotes (
T21434 24846-24847 -RRB- denotes )
T21433 24841-24846 CD denotes 0.001
T21432 24840-24841 FW denotes <
T21431 24839-24840 FW denotes p
T21430 24838-24839 -LRB- denotes (
T21429 24829-24837 NN denotes survival
T21428 24825-24828 CC denotes and
T21427 24821-24824 NNP denotes IAV
T21426 24818-24820 IN denotes of
T21425 24813-24817 NN denotes dose
T21424 24806-24812 JJ denotes lethal
T21423 24804-24805 DT denotes a
T21422 24799-24803 IN denotes with
T21421 24790-24798 VBN denotes infected
T21420 24777-24789 RB denotes intranasally
T21419 24772-24776 VBD denotes were
T21418 24767-24771 NNS denotes mice
T21417 24765-24766 -RRB- denotes )
T21416 24763-24765 CD denotes 11
T21415 24761-24762 SYM denotes =
T21414 24759-24760 JJ denotes n
T21413 24758-24759 -LRB- denotes (
T21412 24747-24757 JJ denotes A20myel-KO
T21411 24743-24746 CC denotes and
T21410 24741-24742 -RRB- denotes )
T21409 24739-24741 CD denotes 11
T21408 24737-24738 SYM denotes =
T21407 24735-24736 FW denotes n
T21406 24734-24735 -LRB- denotes (
T21405 24723-24733 NN denotes A20myel-WT
T21404 24721-24722 . denotes .
T21403 24712-24721 NN denotes infection
T21402 24708-24711 NNP denotes IAV
T21401 24701-24707 JJ denotes lethal
T21400 24693-24700 IN denotes against
T21399 24684-24692 VBZ denotes protects
T21398 24678-24683 NNS denotes cells
T21397 24670-24677 JJ denotes myeloid
T21396 24667-24669 IN denotes in
T21395 24656-24666 NN denotes deficiency
T21394 24652-24655 CD denotes A20
T20976 19016-19019 NNP denotes IAV
T20975 19008-19015 IN denotes against
T20974 18999-19007 VBZ denotes protects
T20973 18993-18998 NNS denotes cells
T20972 18985-18992 JJ denotes myeloid
T20971 18982-18984 IN denotes in
T20970 18971-18981 NN denotes deficiency
T20969 18967-18970 CD denotes A20
T20490 15967-15968 -RRB- denotes )
T20489 15966-15967 NNP denotes B
T20488 15964-15965 DT denotes A
T20487 15963-15964 -LRB- denotes (
T20486 15961-15962 . denotes .
T20485 15950-15961 NNS denotes macrophages
T20484 15941-15949 JJ denotes alveolar
T20483 15937-15940 CC denotes and
T20482 15932-15936 NNP denotes BMDM
T20481 15929-15931 IN denotes in
T20480 15918-15928 NN denotes expression
T20479 15913-15917 NN denotes gene
T20478 15901-15912 JJ denotes IAV-induced
T20477 15891-15900 VBZ denotes regulates
T20476 15880-15890 RB denotes negatively
T20475 15876-15879 CD denotes A20
T20641 16709-16710 . denotes .
T20640 16704-16709 CD denotes 0,001
T20639 16703-16704 FW denotes <
T20638 16702-16703 FW denotes p
T20637 16699-16702 FW denotes ***
T20636 16697-16698 . denotes .
T20635 16686-16697 NNS denotes experiments
T20634 16674-16685 JJ denotes independent
T20633 16672-16673 CD denotes 2
T20632 16668-16671 IN denotes for
T20631 16653-16667 JJ denotes representative
T20630 16649-16652 VBP denotes are
T20629 16641-16648 NNS denotes Results
T20628 16639-16640 . denotes .
T20627 16632-16639 NNS denotes samples
T20626 16630-16631 CD denotes 3
T20625 16628-16629 CD denotes 2
T20624 16625-16627 IN denotes of
T20623 16623-16624 -RRB- denotes )
T20622 16620-16623 NNP denotes SEM
T20621 16618-16619 FW denotes −
T20620 16617-16618 FW denotes /
T20619 16616-16617 FW denotes +
T20618 16615-16616 -LRB- denotes (
T20617 16608-16614 NNS denotes values
T20616 16603-16607 JJ denotes mean
T20615 16593-16602 VBP denotes represent
T20614 16588-16592 NNS denotes bars
T20613 16582-16587 NN denotes Error
T20612 16580-16581 . denotes .
T20611 16579-16580 -RRB- denotes )
T20610 16578-16579 NNP denotes D
T20609 16577-16578 -LRB- denotes (
T20608 16564-16576 NNS denotes technologies
T20607 16551-16563 VBG denotes multiplexing
T20606 16547-16550 CC denotes and
T20605 16541-16546 NNP denotes ELISA
T20604 16538-16540 IN denotes by
T20603 16531-16537 NNS denotes levels
T20602 16523-16530 NN denotes protein
T20601 16518-16522 NNP denotes IFNβ
T20600 16514-16517 CC denotes and
T20599 16509-16513 NNP denotes IL-6
T20598 16505-16508 IN denotes for
T20597 16496-16504 VBN denotes analyzed
T20596 16492-16495 VBD denotes was
T20595 16480-16491 NN denotes supernatant
T20594 16472-16479 NN denotes culture
T20593 16467-16471 NNP denotes Cell
T20592 16465-16466 . denotes .
T20591 16464-16465 -RRB- denotes )
T20590 16463-16464 NNP denotes C
T20589 16462-16463 -LRB- denotes (
T20588 16457-16461 NNP denotes qPCR
T20587 16454-16456 IN denotes by
T20586 16443-16453 VBN denotes determined
T20585 16439-16442 VBD denotes was
T20584 16428-16438 NN denotes expression
T20583 16423-16427 NNP denotes mRNA
T20582 16418-16422 NNP denotes IFNβ
T20581 16414-16417 CC denotes and
T20580 16409-16413 NN denotes IL-6
T20579 16407-16408 . denotes .
T20578 16402-16407 NNS denotes hours
T20577 16399-16401 CD denotes 18
T20576 16395-16398 IN denotes for
T20575 16393-16394 -RRB- denotes )
T20574 16392-16393 LS denotes 1
T20573 16388-16391 FW denotes moi
T20572 16387-16388 -LRB- denotes (
T20571 16383-16386 NNP denotes IAV
T20570 16378-16382 IN denotes with
T20569 16369-16377 VBN denotes infected
T20568 16366-16368 CC denotes or
T20567 16358-16365 VBN denotes treated
T20566 16353-16357 JJ denotes mock
T20565 16348-16352 VBD denotes were
T20564 16336-16347 NNS denotes macrophages
T20563 16327-16335 NNP denotes Alveolar
T20562 16325-16326 -RRB- denotes )
T20561 16324-16325 NNP denotes D
T20560 16322-16323 $ denotes C
T20559 16321-16322 -LRB- denotes (
T20558 16319-16320 . denotes .
T20557 16318-16319 -RRB- denotes )
T20556 16317-16318 NNP denotes B
T20555 16316-16317 -LRB- denotes (
T20554 16303-16315 NNS denotes technologies
T20553 16290-16302 VBG denotes multiplexing
T20552 16286-16289 CC denotes and
T20551 16280-16285 NNP denotes ELISA
T20550 16277-16279 IN denotes by
T20549 16270-16276 NNS denotes levels
T20548 16262-16269 NN denotes protein
T20547 16257-16261 NNP denotes IFNβ
T20546 16253-16256 CC denotes and
T20545 16249-16252 NNP denotes TNF
T20544 16245-16248 IN denotes for
T20543 16236-16244 VBN denotes analyzed
T20542 16232-16235 VBD denotes was
T20541 16220-16231 NN denotes supernatant
T20540 16212-16219 NN denotes culture
T20539 16207-16211 NN denotes cell
T20538 16197-16206 NN denotes infection
T20537 16192-16196 NN denotes post
T20536 16186-16191 NNS denotes hours
T20535 16183-16185 CD denotes 18
T20534 16181-16182 . denotes .
T20533 16180-16181 -RRB- denotes )
T20532 16179-16180 NNP denotes A
T20531 16178-16179 -LRB- denotes (
T20530 16173-16177 NNP denotes qPCR
T20529 16170-16172 IN denotes by
T20528 16161-16169 VBN denotes analyzed
T20527 16157-16160 VBD denotes was
T20526 16146-16156 NN denotes expression
T20525 16141-16145 NNP denotes mRNA
T20524 16137-16140 NNP denotes A20
T20523 16133-16136 CC denotes and
T20522 16128-16132 NNP denotes IFNβ
T20521 16126-16127 , denotes ,
T20520 16122-16126 NNP denotes IL-6
T20519 16118-16121 CC denotes and
T20518 16112-16117 VBN denotes lysed
T20517 16107-16111 VBD denotes were
T20516 16101-16106 NNS denotes cells
T20515 16099-16100 -RRB- denotes )
T20514 16095-16099 VBP denotes p.i.
T20513 16089-16094 NNS denotes hours
T20512 16088-16089 -LRB- denotes (
T20511 16078-16087 NN denotes infection
T20510 16073-16077 NN denotes post
T20509 16067-16072 NNS denotes hours
T20508 16057-16066 JJ denotes different
T20507 16054-16056 IN denotes At
T20506 16052-16053 . denotes .
T20505 16051-16052 -RRB- denotes )
T20504 16050-16051 LS denotes 1
T20503 16046-16049 FW denotes moi
T20502 16045-16046 -LRB- denotes (
T20501 16041-16044 NNP denotes IAV
T20500 16036-16040 IN denotes with
T20499 16027-16035 VBN denotes infected
T20498 16022-16026 VBD denotes were
T20497 16014-16021 NNS denotes animals
T20496 16003-16013 JJ denotes A20myel-KO
T20495 15999-16002 CC denotes and
T20494 15988-15998 JJ denotes A20myel-WT
T20493 15983-15987 IN denotes from
T20492 15974-15982 VBD denotes isolated
T20491 15969-15973 NNP denotes BMDM
T19918 12197-12201 NN denotes lane
T19917 12191-12196 JJ denotes first
T19916 12187-12190 DT denotes the
T19915 12184-12186 TO denotes to
T19914 12175-12183 VBN denotes compared
T19913 12167-12174 NN denotes density
T19912 12158-12166 JJ denotes relative
T19911 12155-12157 IN denotes as
T19910 12145-12154 VBN denotes expressed
T19909 12144-12145 -LRB- denotes (
T19908 12137-12143 NNS denotes graphs
T19907 12133-12136 NN denotes bar
T19906 12130-12132 IN denotes in
T19905 12124-12129 VBN denotes shown
T19904 12121-12123 VBZ denotes is
T19903 12116-12120 CD denotes IRF3
T19902 12112-12115 CC denotes and
T19901 12108-12111 NNS denotes p65
T19900 12100-12107 JJ denotes nuclear
T19899 12096-12099 IN denotes for
T19898 12088-12095 NN denotes density
T19897 12083-12087 NN denotes band
T19896 12080-12082 IN denotes of
T19895 12065-12079 NN denotes Quantification
T19894 12063-12064 . denotes .
T19893 12062-12063 -RRB- denotes )
T19892 12061-12062 NNP denotes C
T19891 12060-12061 -LRB- denotes (
T19890 12050-12059 NNS denotes fractions
T19889 12042-12049 JJ denotes nuclear
T19888 12039-12041 CC denotes or
T19887 12027-12038 JJ denotes cytoplasmic
T19886 12024-12026 IN denotes of
T19885 12009-12023 VBG denotes immunoblotting
T19884 12006-12008 IN denotes by
T19883 11997-12005 VBN denotes analyzed
T19882 11993-11996 VBD denotes was
T19881 11988-11992 NNP denotes IRF3
T19880 11984-11987 CC denotes and
T19879 11982-11983 -RRB- denotes )
T19878 11979-11982 NNS denotes p65
T19877 11978-11979 -LRB- denotes (
T19876 11972-11977 NNP denotes NF-κB
T19875 11969-11971 IN denotes of
T19874 11955-11968 NN denotes translocation
T19873 11947-11954 NNP denotes Nuclear
T19872 11945-11946 . denotes .
T19871 11938-11945 NN denotes control
T19870 11930-11937 VBG denotes loading
T19869 11928-11929 DT denotes a
T19868 11925-11927 IN denotes as
T19867 11920-11924 VBN denotes used
T19866 11917-11919 VB denotes be
T19865 11913-11916 MD denotes can
T19864 11911-11912 -RRB- denotes )
T19863 11903-11911 NN denotes asterisk
T19862 11900-11902 DT denotes an
T19861 11897-11899 IN denotes by
T19860 11887-11896 VBN denotes indicated
T19859 11886-11887 -LRB- denotes (
T19858 11877-11885 NN denotes antibody
T19857 11867-11876 JJ denotes anti-IκBα
T19856 11863-11866 DT denotes the
T19855 11860-11862 IN denotes by
T19854 11849-11859 VBN denotes recognized
T19853 11832-11848 RB denotes non-specifically
T19852 11829-11831 VBZ denotes is
T19851 11824-11828 WDT denotes that
T19850 11819-11823 NN denotes band
T19849 11815-11818 DT denotes The
T19848 11813-11814 . denotes .
T19847 11812-11813 -RRB- denotes )
T19846 11811-11812 NNP denotes B
T19845 11810-11811 -LRB- denotes (
T19844 11801-11809 NNS denotes extracts
T19843 11796-11800 NN denotes cell
T19842 11790-11795 JJ denotes total
T19841 11787-11789 IN denotes of
T19840 11772-11786 VBG denotes immunoblotting
T19839 11769-11771 IN denotes by
T19838 11753-11768 NN denotes phosphorylation
T19837 11748-11752 NNP denotes IRF3
T19836 11744-11747 CC denotes and
T19835 11742-11743 , denotes ,
T19834 11731-11742 NN denotes degradation
T19833 11727-11730 CC denotes and
T19832 11711-11726 NN denotes phosphorylation
T19831 11706-11710 NNP denotes IκBα
T19830 11702-11705 IN denotes for
T19829 11689-11701 NN denotes transfection
T19828 11686-11688 IN denotes of
T19827 11680-11685 NN denotes start
T19826 11676-11679 DT denotes the
T19825 11670-11675 IN denotes after
T19824 11668-11669 -RRB- denotes )
T19823 11661-11668 NNS denotes minutes
T19822 11660-11661 -LRB- denotes (
T19821 11653-11659 NNS denotes points
T19820 11648-11652 NN denotes time
T19819 11638-11647 JJ denotes different
T19818 11635-11637 IN denotes at
T19817 11626-11634 VBD denotes analyzed
T19816 11622-11625 CC denotes and
T19815 11620-11621 -RRB- denotes )
T19814 11619-11620 NNP denotes C
T19813 11618-11619 : denotes :
T19812 11617-11618 PRP denotes I
T19811 11616-11617 -LRB- denotes (
T19810 11612-11616 NN denotes poly
T19809 11608-11611 NNP denotes LMW
T19808 11603-11607 IN denotes with
T19807 11591-11602 VBN denotes transfected
T19806 11586-11590 VBD denotes were
T19805 11581-11585 NNP denotes BMDM
T19804 11579-11580 -RRB- denotes )
T19803 11569-11579 JJ denotes A20myel-WT
T19802 11568-11569 -LRB- denotes (
T19801 11563-11567 NN denotes type
T19800 11558-11562 JJ denotes wild
T19799 11554-11557 CC denotes and
T19798 11543-11553 JJ denotes A20myel-KO
T19797 11541-11542 -RRB- denotes )
T19796 11540-11541 NNP denotes D
T19795 11538-11539 NNP denotes B
T19794 11537-11538 -LRB- denotes (
T19793 11535-11536 . denotes .
T19792 11529-11535 NN denotes set-up
T19791 11525-11528 IN denotes per
T19790 11517-11524 NNS denotes samples
T19789 11515-11516 CD denotes 3
T19788 11512-11514 IN denotes of
T19787 11509-11511 NNP denotes SD
T19786 11507-11508 CD denotes −
T19785 11506-11507 CD denotes /
T19784 11505-11506 VBP denotes +
T19783 11496-11504 NNS denotes averages
T19782 11492-11495 VBP denotes are
T19781 11484-11491 NNS denotes Numbers
T19780 11482-11483 . denotes .
T19779 11471-11482 NN denotes luminometer
T19778 11469-11470 DT denotes a
T19777 11466-11468 IN denotes in
T19776 11457-11465 VBN denotes analyzed
T19775 11453-11456 VBD denotes was
T19774 11444-11452 NNS denotes extracts
T19773 11439-11443 NN denotes cell
T19772 11436-11438 IN denotes in
T19771 11427-11435 NN denotes activity
T19770 11416-11426 JJ denotes Luciferase
T19769 11414-11415 . denotes .
T19768 11411-11414 NNP denotes A20
T19767 11408-11410 IN denotes of
T19766 11400-11407 NNS denotes amounts
T19765 11389-11399 VBG denotes increasing
T19764 11385-11388 CC denotes and
T19763 11383-11384 -RRB- denotes )
T19762 11378-11383 NN denotes right
T19761 11377-11378 -LRB- denotes (
T19760 11372-11376 NNP denotes IRF7
T19759 11370-11371 , denotes ,
T19758 11369-11370 -RRB- denotes )
T19757 11364-11369 NNP denotes 2CARD
T19756 11363-11364 -LRB- denotes (
T19755 11357-11362 NNP denotes RIG-I
T19754 11346-11356 VBG denotes expressing
T19753 11337-11345 NNS denotes plasmids
T19752 11332-11336 IN denotes with
T19751 11323-11331 RB denotes together
T19750 11321-11322 , denotes ,
T19749 11313-11321 NNS denotes plasmids
T19748 11311-11312 -RRB- denotes )
T19747 11306-11311 NN denotes right
T19746 11305-11306 -LRB- denotes (
T19745 11296-11304 NN denotes reporter
T19744 11285-11295 NN denotes luciferase
T19743 11275-11284 JJ denotes dependent
T19742 11270-11274 NNP denotes IRF7
T19741 11267-11269 CC denotes or
T19740 11265-11266 -RRB- denotes )
T19739 11259-11265 JJ denotes middle
T19738 11258-11259 -LRB- denotes (
T19737 11253-11257 NNP denotes IRF3
T19736 11251-11252 , denotes ,
T19735 11250-11251 -RRB- denotes )
T19734 11246-11250 VBN denotes left
T19733 11245-11246 -LRB- denotes (
T19732 11239-11244 NNP denotes NF-κB
T19731 11234-11238 IN denotes with
T19730 11222-11233 VBN denotes transfected
T19729 11217-11221 VBD denotes were
T19728 11211-11216 NNS denotes cells
T19727 11203-11210 CD denotes HEK293T
T19726 11201-11202 -RRB- denotes )
T19725 11200-11201 NNP denotes A
T19724 11199-11200 -LRB- denotes (
T19723 11197-11198 . denotes .
T19722 11186-11197 NN denotes stimulation
T19721 11180-11185 NNP denotes RIG-I
T19720 11177-11179 TO denotes to
T19719 11168-11176 NN denotes response
T19718 11165-11167 IN denotes in
T19717 11154-11164 NN denotes activation
T19716 11149-11153 JJ denotes IRF3
T19715 11145-11148 CC denotes and
T19714 11139-11144 JJ denotes NF-κB
T19713 11130-11138 NNS denotes inhibits
T19712 11126-11129 CD denotes A20
T19974 12450-12451 . denotes .
T19973 12439-12450 NNS denotes experiments
T19972 12427-12438 JJ denotes independent
T19971 12425-12426 CD denotes 2
T19970 12422-12424 IN denotes of
T19969 12407-12421 NN denotes representative
T19968 12403-12406 VBP denotes are
T19967 12398-12402 NNS denotes Data
T19966 12396-12397 . denotes .
T19965 12395-12396 -RRB- denotes )
T19964 12394-12395 NNP denotes D
T19963 12393-12394 -LRB- denotes (
T19962 12385-12392 NN denotes section
T19961 12376-12383 NNS denotes methods
T19960 12372-12375 CC denotes and
T19959 12362-12371 NNS denotes materials
T19958 12357-12360 DT denotes the
T19957 12354-12356 IN denotes in
T19956 12344-12353 VBN denotes described
T19955 12341-12343 IN denotes as
T19954 12339-12340 -RRB- denotes )
T19953 12335-12339 NNP denotes IFNβ
T19952 12331-12334 CC denotes and
T19951 12327-12330 NNP denotes TNF
T19950 12326-12327 -LRB- denotes (
T19949 12320-12325 NNP denotes ELISA
T19948 12316-12319 CC denotes and
T19947 12314-12315 -RRB- denotes )
T19946 12310-12314 NN denotes IL-6
T19945 12309-12310 -LRB- denotes (
T19944 12300-12308 NN denotes bioassay
T19943 12297-12299 IN denotes by
T19942 12286-12296 VBN denotes determined
T19941 12281-12285 VBD denotes were
T19940 12279-12280 -RRB- denotes )
T19939 12278-12279 NNP denotes B
T19938 12277-12278 -LRB- denotes (
T19937 12274-12276 IN denotes in
T19936 12269-12273 VBN denotes used
T19935 12263-12268 NNS denotes cells
T19934 12260-12262 IN denotes of
T19933 12248-12259 NN denotes supernatant
T19932 12244-12247 DT denotes the
T19931 12241-12243 IN denotes in
T19930 12234-12240 NNS denotes levels
T19929 12229-12233 NNP denotes IFNβ
T19928 12225-12228 CC denotes and
T19927 12221-12224 NNP denotes TNF
T19926 12219-12220 , denotes ,
T19925 12215-12219 NN denotes IL-6
T19924 12213-12214 . denotes .
T19923 12212-12213 -RRB- denotes )
T19922 12211-12212 CD denotes 0
T19921 12206-12210 NN denotes time
T19920 12204-12205 SYM denotes =
T19919 12201-12202 : denotes ;
T19252 41811-41812 . denotes .
T19251 41810-41811 -RRB- denotes )
T19250 41808-41810 NNP denotes CA
T19249 41806-41807 , denotes ,
T19248 41801-41806 NNP denotes Diego
T19247 41797-41800 NNP denotes San
T19246 41795-41796 , denotes ,
T19245 41787-41795 NNP denotes GraphPad
T19244 41785-41786 , denotes ,
T19243 41784-41785 CD denotes 5
T19242 41776-41783 NN denotes version
T19241 41770-41775 NNP denotes Prism
T19240 41761-41769 NNP denotes GraphPad
T19239 41760-41761 -LRB- denotes (
T19238 41755-41759 NN denotes test
T19237 41746-41754 JJ denotes log-rank
T19236 41742-41745 DT denotes the
T19235 41736-41741 VBG denotes using
T19234 41729-41735 VBZ denotes curves
T19233 41716-41728 NNP denotes Kaplan-Meier
T19232 41706-41715 VBG denotes comparing
T19231 41703-41705 IN denotes by
T19230 41694-41702 VBN denotes analyzed
T19229 41690-41693 VBD denotes was
T19228 41684-41689 NNS denotes rates
T19227 41675-41683 NN denotes survival
T19226 41667-41674 IN denotes between
T19225 41655-41666 NNS denotes differences
T19224 41652-41654 IN denotes of
T19223 41639-41651 NN denotes significance
T19222 41627-41638 NNP denotes Statistical
T19221 41625-41626 . denotes .
T19220 41621-41625 NNS denotes data
T19219 41612-41620 JJ denotes unpaired
T19218 41608-41611 IN denotes for
T19217 41601-41607 NNP denotes U-test
T19216 41588-41600 NNP denotes Mann-Whitney
T19215 41584-41587 DT denotes the
T19214 41578-41583 VBG denotes using
T19213 41567-41577 VBN denotes calculated
T19212 41562-41566 VBD denotes were
T19211 41560-41561 -RRB- denotes )
T19210 41555-41560 NN denotes group
T19209 41551-41554 IN denotes per
T19208 41546-41550 NNS denotes mice
T19207 41544-41545 CD denotes 5
T19206 41538-41543 JJS denotes least
T19205 41535-41537 IN denotes at
T19204 41534-41535 -LRB- denotes (
T19203 41522-41533 NNS denotes experiments
T19202 41517-41521 NN denotes vivo
T19201 41514-41516 IN denotes in
T19200 41510-41513 IN denotes for
T19199 41498-41509 NNS denotes differences
T19198 41494-41497 DT denotes The
T19197 41492-41493 . denotes .
T19196 41487-41492 NNP denotes ANOVA
T19195 41479-41486 JJ denotes two-way
T19194 41473-41478 VBG denotes using
T19193 41464-41472 VBN denotes assessed
T19192 41460-41463 VBD denotes was
T19191 41453-41459 NNS denotes groups
T19190 41445-41452 IN denotes between
T19189 41432-41444 NN denotes significance
T19188 41420-41431 NNP denotes Statistical
T19187 41418-41419 . denotes .
T19186 41415-41418 NNP denotes SEM
T19185 41413-41414 NN denotes ±
T19184 41408-41412 JJ denotes mean
T19183 41404-41407 DT denotes the
T19182 41401-41403 IN denotes as
T19181 41391-41400 VBN denotes expressed
T19180 41387-41390 VBP denotes are
T19179 41379-41386 NNS denotes Results
T19178 41368-41378 NNPS denotes Statistics
T19024 41365-41366 . denotes .
T19023 41359-41365 NNS denotes values
T19022 41354-41358 NNP denotes HPRT
T19021 41351-41353 TO denotes to
T19020 41342-41350 JJ denotes relative
T19019 41332-41341 VBN denotes expressed
T19018 41328-41331 VBP denotes are
T19017 41320-41327 NNS denotes Results
T19016 41318-41319 . denotes .
T19015 41317-41318 -RRB- denotes )
T19014 41313-41317 NNP denotes ΔΔCT
T19013 41312-41313 -LRB- denotes (
T19012 41305-41311 NN denotes method
T19011 41302-41304 NNP denotes CT
T19010 41290-41301 JJ denotes comparative
T19009 41286-41289 DT denotes the
T19008 41280-41285 VBG denotes using
T19007 41270-41279 VBN denotes performed
T19006 41266-41269 VBD denotes was
T19005 41251-41265 NN denotes Quantification
T19004 41249-41250 . denotes .
T19003 41248-41249 -RRB- denotes )
T19002 41215-41248 NN denotes http://perlprimer.sourceforge.net
T19001 41214-41215 -LRB- denotes (
T19000 41203-41213 NNP denotes PerlPrimer
T18999 41198-41202 IN denotes with
T18998 41189-41197 VBN denotes designed
T18997 41184-41188 VBD denotes were
T18996 41176-41183 NNS denotes Primers
T18995 41174-41175 . denotes .
T18994 41173-41174 NN denotes ′
T18993 41149-41173 NN denotes GATCTCTTAGCACAAGGATGGC-3
T18992 41148-41149 : denotes -
T18991 41147-41148 SYM denotes ′
T18990 41146-41147 CD denotes 5
T18989 41142-41145 CC denotes and
T18988 41140-41141 NN denotes ′
T18987 41116-41140 NN denotes TGATGAGCTACTACTGGTCAGC-3
T18986 41115-41116 : denotes -
T18985 41114-41115 SYM denotes ′
T18984 41113-41114 CD denotes 5
T18983 41111-41112 : denotes :
T18982 41106-41111 NNP denotes IFNα4
T18981 41102-41105 CC denotes and
T18980 41100-41101 NN denotes ′
T18979 41078-41100 NN denotes TGAGTGTGGCTATGACTTCG-3
T18978 41077-41078 : denotes -
T18977 41076-41077 SYM denotes ′
T18976 41075-41076 CD denotes 5
T18975 41071-41074 CC denotes and
T18974 41069-41070 NN denotes ′
T18973 41047-41069 NN denotes GAGCCTCTAACCAGTTCCAG-3
T18972 41046-41047 : denotes -
T18971 41045-41046 SYM denotes ′
T18970 41044-41045 CD denotes 5
T18969 41042-41043 : denotes :
T18968 41037-41042 NNP denotes CXCL1
T18967 41035-41036 : denotes ;
T18966 41034-41035 NN denotes ′
T18965 41009-41034 NN denotes GCATTAGCTTCAGATTTACGGGT-3
T18964 41008-41009 : denotes -
T18963 41007-41008 SYM denotes ′
T18962 41006-41007 CD denotes 5
T18961 41002-41005 CC denotes and
T18960 41000-41001 NN denotes ′
T18959 40975-41000 NN denotes TTAAAAACCTGGATCGGAACCAA-3
T18958 40974-40975 : denotes -
T18957 40973-40974 SYM denotes ′
T18956 40972-40973 CD denotes 5
T18955 40970-40971 : denotes :
T18954 40966-40970 NNP denotes CCL2
T18953 40964-40965 : denotes ;
T18952 40963-40964 NN denotes ′
T18951 40941-40963 NN denotes GTTGTCCCATTCGTCATTCC-3
T18950 40940-40941 : denotes -
T18949 40939-40940 SYM denotes ′
T18948 40938-40939 CD denotes 5
T18947 40934-40937 CC denotes and
T18946 40932-40933 NN denotes ′
T18945 40908-40932 NN denotes AAACCAATGGTGATGGAAACTG-3
T18944 40907-40908 : denotes -
T18943 40906-40907 SYM denotes ′
T18942 40905-40906 CD denotes 5
T18941 40903-40904 : denotes :
T18940 40900-40903 NNP denotes A20
T18939 40898-40899 : denotes ;
T18938 40897-40898 NN denotes ′
T18937 40871-40897 NN denotes GACCTTTCAAATGCAGTAGATTCA-3
T18936 40870-40871 : denotes -
T18935 40869-40870 SYM denotes ′
T18934 40868-40869 CD denotes 5
T18933 40864-40867 CC denotes and
T18932 40862-40863 NN denotes ′
T18931 40840-40862 NN denotes TCAGAATGAGTGGTGGTTGC-3
T18930 40839-40840 : denotes -
T18929 40838-40839 SYM denotes ′
T18928 40837-40838 CD denotes 5
T18927 40835-40836 : denotes :
T18926 40831-40835 NNP denotes IFNβ
T18925 40829-40830 : denotes ;
T18924 40828-40829 NN denotes ′
T18923 40802-40828 NN denotes AAGTGCATCATCGTTGTTCATACA-3
T18922 40801-40802 : denotes -
T18921 40800-40801 SYM denotes ′
T18920 40799-40800 CD denotes 5
T18919 40795-40798 CC denotes and
T18918 40793-40794 NN denotes ′
T18917 40768-40793 NN denotes GAGGATACCACTCCCAACAGACC-3
T18916 40767-40768 : denotes -
T18915 40766-40767 SYM denotes ′
T18914 40765-40766 CD denotes 5
T18913 40763-40764 : denotes :
T18912 40759-40763 NNP denotes IL-6
T18911 40757-40758 : denotes ;
T18910 40756-40757 NN denotes ′
T18909 40733-40756 JJ denotes CGTGATTCAAATCCCTGAAGT-3
T18908 40732-40733 CD denotes ′
T18907 40731-40732 CD denotes 5
T18906 40727-40730 CC denotes and
T18905 40725-40726 NN denotes ′
T18904 40702-40725 NN denotes AGTGTTGGATACAGGCCAGAC-3
T18903 40701-40702 : denotes -
T18902 40700-40701 SYM denotes ′
T18901 40699-40700 CD denotes 5
T18900 40697-40698 : denotes :
T18899 40693-40697 NNP denotes HPRT
T18898 40691-40692 : denotes :
T18897 40684-40691 NNS denotes primers
T18896 40674-40683 VBG denotes following
T18895 40670-40673 DT denotes the
T18894 40665-40669 IN denotes with
T18893 40663-40664 -RRB- denotes )
T18892 40658-40663 NNP denotes Roche
T18891 40657-40658 -LRB- denotes (
T18890 40650-40656 NN denotes system
T18889 40640-40649 NN denotes detection
T18888 40636-40639 CD denotes 480
T18887 40624-40635 NNP denotes Lightcycler
T18886 40620-40623 DT denotes the
T18885 40617-40619 IN denotes in
T18884 40615-40616 -RRB- denotes )
T18883 40610-40615 NNP denotes Roche
T18882 40609-40610 -LRB- denotes (
T18881 40607-40608 PRP denotes I
T18880 40603-40606 NN denotes mix
T18879 40596-40602 VBP denotes master
T18878 40594-40595 PRP denotes I
T18877 40588-40593 NNP denotes Green
T18876 40583-40587 NNP denotes SYBR
T18875 40577-40582 VBG denotes using
T18874 40574-40576 IN denotes by
T18873 40564-40573 VBN denotes performed
T18872 40560-40563 VBD denotes was
T18871 40555-40559 NNP denotes qPCR
T18870 40553-40554 . denotes .
T18869 40541-40553 NNS denotes instructions
T18868 40538-40540 POS denotes 's
T18867 40526-40538 NN denotes manufacturer
T18866 40522-40525 DT denotes the
T18865 40519-40521 TO denotes to
T18864 40509-40518 VBG denotes according
T18863 40507-40508 -RRB- denotes )
T18862 40501-40507 NNP denotes BioRad
T18861 40500-40501 -LRB- denotes (
T18860 40496-40499 NN denotes kit
T18859 40486-40495 NN denotes synthesis
T18858 40481-40485 NNP denotes cDNA
T18857 40473-40480 NNP denotes iScript
T18856 40468-40472 IN denotes with
T18855 40463-40467 NNP denotes cDNA
T18854 40458-40462 IN denotes into
T18853 40446-40457 VBN denotes transcribed
T18852 40438-40445 VB denotes reverse
T18851 40434-40437 CC denotes and
T18850 40432-40433 -RRB- denotes )
T18849 40426-40432 NNP denotes BioRad
T18848 40425-40426 -LRB- denotes (
T18847 40421-40424 NN denotes kit
T18846 40416-40420 NNS denotes mini
T18845 40412-40415 NNP denotes RNA
T18844 40406-40411 NNP denotes Total
T18843 40400-40405 NNP denotes Aurum
T18842 40394-40399 VBG denotes using
T18841 40384-40393 VBN denotes extracted
T18840 40380-40383 VBD denotes was
T18839 40376-40379 NNP denotes RNA
T18838 40370-40375 NNP denotes Total
T18837 40365-40369 NNP denotes qPCR
T18836 40361-40364 CC denotes and
T18835 40351-40360 NN denotes synthesis
T18526 40328-40329 . denotes .
T18525 40323-40328 NN denotes fluid
T18524 40319-40322 NNP denotes BAL
T18523 40316-40318 IN denotes in
T18522 40310-40315 NN denotes MIP-2
T18521 40307-40309 IN denotes of
T18520 40297-40306 NN denotes detection
T18519 40293-40296 DT denotes the
T18518 40289-40292 IN denotes for
T18517 40284-40288 VBN denotes used
T18516 40280-40283 VBD denotes was
T18515 40278-40279 -RRB- denotes )
T18514 40269-40278 NNP denotes Millipore
T18513 40268-40269 -LRB- denotes (
T18512 40257-40267 NN denotes technology
T18511 40247-40256 NNP denotes Milliplex
T18510 40245-40246 . denotes .
T18509 40233-40245 NNS denotes instructions
T18508 40230-40232 POS denotes 's
T18507 40218-40230 NN denotes manufacturer
T18506 40214-40217 DT denotes the
T18505 40211-40213 TO denotes to
T18504 40201-40210 VBG denotes according
T18503 40190-40200 NN denotes technology
T18502 40188-40189 -RRB- denotes )
T18501 40182-40188 NNP denotes BioRad
T18500 40181-40182 -LRB- denotes (
T18499 40173-40180 NNP denotes Bioplex
T18498 40167-40172 VBG denotes using
T18497 40157-40166 VBN denotes performed
T18496 40153-40156 VBD denotes was
T18495 40147-40152 NN denotes fluid
T18494 40143-40146 NNP denotes BAL
T18493 40140-40142 IN denotes in
T18492 40135-40139 NNP denotes IL-6
T18491 40131-40134 CC denotes and
T18490 40125-40130 NNP denotes IL-1β
T18489 40123-40124 , denotes ,
T18488 40120-40123 NNP denotes TNF
T18487 40118-40119 , denotes ,
T18486 40116-40118 NNP denotes KC
T18485 40114-40115 , denotes ,
T18484 40109-40114 NNP denotes MCP-1
T18483 40106-40108 IN denotes of
T18482 40096-40105 NNP denotes Detection
T18481 40094-40095 . denotes .
T18480 40093-40094 -RRB- denotes )
T18479 40081-40093 NNS denotes eBiosciences
T18478 40080-40081 -LRB- denotes (
T18477 40069-40079 NNS denotes antibodies
T18476 40067-40068 -RRB- denotes )
T18475 40061-40067 NN denotes R4-6A2
T18474 40060-40061 -LRB- denotes (
T18473 40050-40059 NN denotes detection
T18472 40046-40049 CC denotes and
T18471 40044-40045 -RRB- denotes )
T18470 40042-40044 CD denotes .2
T18469 40038-40042 NNP denotes XMG1
T18448 39932-39934 DT denotes an
T18447 39927-39931 IN denotes with
T18446 39916-39926 VBN denotes determined
T18445 39911-39915 VBD denotes were
T18444 39904-39910 NNS denotes levels
T18443 39896-39903 NN denotes protein
T18442 39891-39895 NNP denotes IFNβ
T18441 39887-39890 CC denotes and
T18440 39882-39886 NNP denotes IFNα
T18439 39880-39881 . denotes .
T18438 39870-39880 NNS denotes antibodies
T18437 39868-39869 -RRB- denotes )
T18436 39857-39868 NNP denotes eBioscience
T18435 39855-39856 , denotes ,
T18434 39849-39855 NN denotes R4-6A2
T18433 39848-39849 -LRB- denotes (
T18432 39838-39847 NN denotes detection
T18431 39834-39837 CC denotes and
T18430 39832-39833 -RRB- denotes )
T18429 39821-39832 NNP denotes eBioscience
T18428 39819-39820 , denotes ,
T18427 39813-39819 CD denotes TN3-19
T18426 39812-39813 -LRB- denotes (
T18425 39804-39811 NN denotes coating
T18424 39800-39803 NNP denotes TNF
T18423 39795-39799 IN denotes with
T18422 39788-39794 VBN denotes coated
T18421 39783-39787 VBD denotes were
T18420 39776-39782 NNS denotes plates
T18419 39768-39775 JJ denotes 96-well
T18418 39766-39767 , denotes ,
T18417 39761-39766 NNP denotes ELISA
T18416 39757-39760 NNP denotes TNF
T18415 39753-39756 IN denotes For
T18414 39738-39752 NN denotes quantification
T18413 39729-39737 NNP denotes Cytokine
T18834 40346-40350 NNP denotes cDNA
T18833 40344-40345 , denotes ,
T18832 40335-40344 NN denotes isolation
T18831 40331-40334 NNP denotes RNA
T18144 39726-39727 . denotes .
T18143 39721-39726 NNS denotes cells
T18142 39716-39720 JJ denotes dead
T18141 39712-39715 CC denotes and
T18140 39707-39711 JJ denotes live
T18139 39699-39706 IN denotes between
T18138 39686-39698 JJ denotes discriminate
T18137 39683-39685 TO denotes to
T18136 39678-39682 VBN denotes used
T18135 39674-39677 VBD denotes was
T18134 39667-39673 NN denotes iodide
T18133 39657-39666 NNP denotes Propidium
T18132 39655-39656 . denotes .
T18131 39654-39655 -RRB- denotes )
T18130 39643-39654 NNPS denotes Biosciences
T18129 39640-39642 NNP denotes BD
T18128 39639-39640 -LRB- denotes (
T18127 39630-39638 NN denotes software
T18126 39621-39629 NNP denotes FACSDiva
T18125 39615-39620 VBG denotes using
T18124 39606-39614 VBD denotes analyzed
T18123 39602-39605 CC denotes and
T18122 39592-39601 NNP denotes Cytometer
T18121 39586-39591 NNP denotes LSRII
T18120 39584-39585 DT denotes a
T18119 39581-39583 IN denotes on
T18118 39572-39580 VBN denotes acquired
T18117 39567-39571 VBD denotes were
T18116 39559-39566 NNS denotes Samples
T18115 39557-39558 . denotes .
T18114 39547-39557 NNP denotes Pharmingen
T18113 39544-39546 NNP denotes BD
T18112 39539-39543 IN denotes from
T18111 39537-39538 -RRB- denotes )
T18110 39535-39537 NNP denotes G2
T18109 39532-39535 CD denotes 2.4
T18108 39531-39532 -LRB- denotes (
T18107 39523-39530 NNP denotes CD16/32
T18106 39519-39522 CC denotes and
T18105 39517-39518 -RRB- denotes )
T18104 39515-39517 CD denotes .2
T18103 39511-39515 NNP denotes XMG1
T18102 39510-39511 -LRB- denotes (
T18101 39506-39509 CD denotes 647
T18100 39500-39505 NNP denotes Alexa
T18099 39495-39499 NNP denotes IFNγ
T18098 39493-39494 , denotes ,
T18097 39492-39493 -RRB- denotes )
T18096 39490-39492 CD denotes .7
T18095 39486-39490 CD denotes 53-6
T18094 39485-39486 -LRB- denotes (
T18093 39479-39484 NNP denotes PerCP
T18092 39474-39478 NNP denotes CD8α
T18091 39472-39473 , denotes ,
T18090 39471-39472 -RRB- denotes )
T18089 39466-39471 NNP denotes M1/70
T18088 39465-39466 -LRB- denotes (
T18087 39457-39464 NNP denotes APC-Cy7
T18086 39451-39456 NNP denotes CD11b
T18085 39449-39450 , denotes ,
T18084 39448-39449 -RRB- denotes )
T18083 39445-39448 NNP denotes 1A8
T18082 39444-39445 -LRB- denotes (
T18081 39441-39443 NNP denotes PE
T18080 39436-39440 NNP denotes Ly6G
T18079 39434-39435 , denotes ,
T18078 39433-39434 -RRB- denotes )
T18077 39428-39433 NN denotes AL-21
T18076 39427-39428 -LRB- denotes (
T18075 39422-39426 CD denotes v450
T18074 39414-39421 NNP denotes Horizon
T18073 39409-39413 NNP denotes Ly6C
T18072 39407-39408 , denotes ,
T18071 39406-39407 -RRB- denotes )
T18070 39402-39406 NNP denotes 17A2
T18069 39401-39402 -LRB- denotes (
T18068 39396-39400 NN denotes v450
T18067 39388-39395 NNP denotes Horizon
T18066 39380-39387 JJ denotes Complex
T18065 39370-39379 NNP denotes Molecular
T18064 39366-39369 NNP denotes CD3
T18063 39362-39365 CC denotes and
T18062 39349-39361 NNPS denotes eBiosciences
T18061 39344-39348 IN denotes from
T18060 39342-39343 -RRB- denotes )
T18059 39338-39342 NNP denotes NGZB
T18058 39337-39338 -LRB- denotes (
T18057 39332-39336 NNP denotes FITC
T18056 39330-39331 NNP denotes B
T18055 39321-39329 NNP denotes Granzyme
T18054 39319-39320 , denotes ,
T18053 39318-39319 -RRB- denotes )
T18052 39312-39318 NNP denotes MEL-14
T18051 39311-39312 -LRB- denotes (
T18050 39308-39310 NNP denotes PE
T18049 39302-39307 NNP denotes CD62L
T18048 39300-39301 , denotes ,
T18047 39299-39300 -RRB- denotes )
T18046 39296-39299 NNP denotes BM8
T18045 39295-39296 -LRB- denotes (
T18044 39291-39294 NNP denotes APC
T18043 39285-39290 NNP denotes F4/80
T18042 39283-39284 , denotes ,
T18041 39282-39283 -RRB- denotes )
T18040 39278-39282 NN denotes N418
T18039 39277-39278 -LRB- denotes (
T18038 39274-39276 CD denotes .5
T18037 39265-39274 NNP denotes PerCP-Cy5
T18036 39259-39264 NNP denotes CD11c
T18035 39257-39258 , denotes ,
T18034 39256-39257 -RRB- denotes )
T18033 39251-39256 CD denotes .15.2
T18032 39245-39251 NNP denotes M5/114
T18031 39244-39245 -LRB- denotes (
T18030 39239-39243 NNP denotes FITC
T18029 39237-39238 -RRB- denotes )
T18028 39230-39237 NNP denotes I-A/I-E
T18027 39229-39230 -LRB- denotes (
T17996 39049-39052 DT denotes the
T17995 39045-39048 IN denotes For
T17994 39043-39044 . denotes .
T17993 39039-39043 NN denotes mesh
T17992 39033-39038 NN denotes nylon
T17991 39030-39032 NN denotes µm
T17990 39027-39029 CD denotes 40
T17989 39023-39026 CC denotes and
T17988 39020-39022 NN denotes µm
T17987 39017-39019 CD denotes 70
T17986 39015-39016 DT denotes a
T17985 39007-39014 IN denotes through
T17984 38998-39006 VBN denotes filtered
T17983 38993-38997 VBD denotes were
T17982 38985-38992 NNS denotes samples
T17981 38983-38984 , denotes ,
T17980 38971-38983 RB denotes Subsequently
T17979 38969-38970 . denotes .
T17978 38966-38969 NN denotes min
T17977 38963-38965 CD denotes 30
T17976 38959-38962 IN denotes for
T17975 38957-38958 NNP denotes C
T17974 38956-38957 CD denotes °
T17973 38954-38956 CD denotes 37
T18468 40037-40038 -LRB- denotes (
T18467 40029-40036 NN denotes coating
T18466 40024-40028 NNP denotes IFNγ
T18465 40019-40023 IN denotes with
T18464 40012-40018 VBN denotes coated
T18463 40007-40011 VBD denotes were
T18462 40000-40006 NNS denotes plates
T18461 39992-39999 JJ denotes 96-well
T18460 39990-39991 , denotes ,
T18459 39985-39990 NNP denotes ELISA
T18458 39980-39984 NNP denotes IFNγ
T18457 39976-39979 IN denotes For
T18456 39974-39975 . denotes .
T18455 39973-39974 -RRB- denotes )
T18454 39961-39973 NNPS denotes Laboratories
T18453 39950-39960 NNP denotes Biomedical
T18452 39946-39949 NNP denotes PBL
T18451 39945-39946 -LRB- denotes (
T18450 39941-39944 NN denotes kit
T18449 39935-39940 NNP denotes ELISA
T17972 38951-38953 IN denotes at
T17971 38949-38950 -RRB- denotes )
T17970 38944-38949 NNP denotes Roche
T17969 38942-38943 : denotes ;
T17968 38938-38942 NNP denotes U/ml
T17967 38934-38937 CD denotes 100
T17966 38933-38934 -LRB- denotes (
T17965 38927-38932 NNP denotes DNAse
T17964 38923-38926 CC denotes and
T17963 38921-38922 -RRB- denotes )
T17962 38916-38921 NNP denotes Sigma
T17961 38914-38915 : denotes ;
T17960 38909-38914 NN denotes mg/ml
T17959 38907-38908 CD denotes 1
T17958 38906-38907 -LRB- denotes (
T17957 38903-38905 NNP denotes IV
T17956 38898-38902 NN denotes type
T17955 38886-38897 NN denotes collagenase
T17954 38881-38885 IN denotes with
T17953 38871-38880 VBN denotes incubated
T17952 38867-38870 CC denotes and
T17951 38857-38866 VBN denotes dissected
T17950 38852-38856 VBD denotes were
T17076 37500-37501 . denotes .
T17075 37489-37500 NNS denotes antibiotics
T17074 37485-37488 CC denotes and
T17073 37476-37484 NN denotes pyruvate
T17072 37469-37475 NN denotes sodium
T17071 37466-37468 NNP denotes mM
T17070 37462-37465 CD denotes 0.4
T17069 37460-37461 , denotes ,
T17068 37449-37460 NNP denotes L-glutamine
T17067 37446-37448 NNP denotes mM
T17066 37444-37445 CD denotes 2
T17065 37442-37443 , denotes ,
T17064 37439-37442 NNP denotes FCS
T17063 37437-37438 NN denotes %
T17062 37436-37437 CD denotes 1
T17061 37431-37435 IN denotes with
T17060 37418-37430 VBN denotes supplemented
T17059 37416-37417 -RRB- denotes )
T17058 37411-37416 NNP denotes Gibco
T17057 37410-37411 -LRB- denotes (
T17056 37405-37409 CD denotes 1640
T17055 37400-37404 NNP denotes RPMI
T17054 37397-37399 IN denotes in
T17053 37388-37396 VBN denotes cultured
T17052 37383-37387 VBD denotes were
T17051 37371-37382 NNS denotes macrophages
T17050 37362-37370 NNP denotes Alveolar
T17049 37360-37361 . denotes .
T17048 37356-37360 NNP denotes EDTA
T17047 37353-37355 NNP denotes mM
T17046 37351-37352 CD denotes 1
T17045 37340-37350 VBG denotes containing
T17044 37335-37339 NNP denotes HBSS
T17043 37330-37334 IN denotes with
T17042 37324-37329 NNS denotes times
T17041 37322-37323 CD denotes 4
T17040 37314-37321 VBN denotes flushed
T17039 37310-37313 VBD denotes was
T17038 37305-37309 NN denotes lung
T17037 37301-37304 DT denotes the
T17036 37297-37300 CC denotes and
T17035 37287-37296 VBN denotes canulated
T17034 37283-37286 VBD denotes was
T17033 37275-37282 NN denotes trachea
T17032 37271-37274 DT denotes the
T17031 37269-37270 , denotes ,
T17030 37258-37269 NNS denotes macrophages
T17029 37249-37257 JJ denotes alveolar
T17028 37246-37248 IN denotes of
T17027 37236-37245 NN denotes isolation
T17026 37232-37235 DT denotes the
T17025 37228-37231 IN denotes For
T17024 37226-37227 . denotes .
T17023 37216-37226 NNS denotes antibodies
T17022 37207-37215 JJ denotes specific
T17021 37201-37206 NNP denotes CD11b
T17020 37197-37200 CC denotes and
T17019 37191-37196 NNP denotes F4/80
T17018 37185-37190 VBG denotes using
T17017 37175-37184 NN denotes cytometry
T17016 37170-37174 NN denotes flow
T17015 37167-37169 IN denotes by
T17014 37158-37166 VBN denotes measured
T17013 37155-37157 IN denotes as
T17012 37148-37154 NN denotes purity
T17011 37146-37147 NN denotes %
T17010 37144-37146 CD denotes 95
T17009 37143-37144 CD denotes ≥
T17008 37140-37142 IN denotes of
T17007 37135-37139 VBD denotes were
T17006 37130-37134 NNP denotes BMDM
T17005 37128-37129 . denotes .
T17004 37123-37128 NNP denotes M-CSF
T17003 37111-37122 JJ denotes recombinant
T17002 37105-37110 JJ denotes ng/ml
T17001 37102-37104 CD denotes 40
T17000 37098-37101 CC denotes and
T16999 37086-37097 NNS denotes antibiotics
T16998 37084-37085 , denotes ,
T16997 37076-37084 NN denotes pyruvate
T16996 37069-37075 NN denotes sodium
T16995 37066-37068 NNP denotes mM
T16994 37062-37065 CD denotes 0.4
T16993 37060-37061 , denotes ,
T16992 37049-37060 NNP denotes L-glutamine
T16991 37046-37048 NNP denotes mM
T16990 37044-37045 CD denotes 2
T16989 37042-37043 , denotes ,
T16988 37039-37042 NNP denotes FCS
T16987 37037-37038 NN denotes %
T16986 37035-37037 CD denotes 10
T16985 37030-37034 IN denotes with
T16984 37017-37029 VBN denotes supplemented
T16983 37015-37016 -RRB- denotes )
T16982 37010-37015 NNP denotes Gibco
T16981 37009-37010 -LRB- denotes (
T16980 37004-37008 CD denotes 1640
T16979 36999-37003 NNP denotes RPMI
T16978 36996-36998 IN denotes in
T16977 36991-36995 NNS denotes days
T16976 36989-36990 CD denotes 7
T16975 36980-36988 VBN denotes cultured
T16974 36975-36979 VBD denotes were
T16973 36969-36974 NNS denotes cells
T16972 36962-36968 NN denotes marrow
T16971 36957-36961 NN denotes bone
T16970 36955-36956 , denotes ,
T16969 36951-36955 NNP denotes BMDM
T16968 36948-36950 IN denotes of
T16967 36937-36947 NN denotes generation
T16966 36933-36936 DT denotes the
T16965 36929-36932 IN denotes For
T16964 36927-36928 . denotes .
T16963 36896-36927 NN denotes http://bccm.belspo.be/index.php
T16962 36887-36895 NN denotes databank
T16961 36879-36886 NN denotes plasmid
T16960 36869-36878 NNP denotes BCCM-LMBP
T16959 36865-36868 DT denotes the
T16958 36862-36864 IN denotes at
T16957 36857-36861 NNS denotes maps
T16956 36848-36856 NN denotes sequence
T16955 36839-36847 JJ denotes detailed
T16954 36834-36838 IN denotes with
T16953 36828-36833 RP denotes along
T16952 36818-36827 VBN denotes presented
T16951 36814-36817 VBP denotes are
T16950 36805-36813 NNS denotes plasmids
T16949 36802-36804 IN denotes of
T16948 36794-36801 NNS denotes Details
T16947 36792-36793 . denotes .
T16946 36779-36792 NN denotes normalization
T16945 36768-36778 NN denotes efficiency
T16944 36755-36767 NN denotes transfection
T16943 36751-36754 IN denotes for
T16942 36749-36750 -RRB- denotes )
T16941 36741-36749 NNP denotes LMBP4341
T16940 36740-36741 -LRB- denotes (
T16939 36728-36739 NNP denotes pACTbetagal
T16938 36724-36727 CC denotes and
T16937 36722-36723 , denotes ,
T16936 36721-36722 -RRB- denotes )
T16935 36715-36721 NNP denotes Canada
T16934 36713-36714 , denotes ,
T16933 36707-36713 NNP denotes Quebec
T16932 36705-36706 , denotes ,
T16931 36697-36705 NNP denotes Montreal
T16930 36695-36696 , denotes ,
T16929 36685-36695 NNP denotes University
T16928 36678-36684 NNP denotes McGill
T16927 36676-36677 , denotes ,
T16926 36669-36676 NNP denotes Hiscott
T16827 36124-36129 VBN denotes grown
T16826 36119-36123 VBD denotes were
T16825 36113-36118 NNS denotes cells
T16824 36108-36112 NNP denotes MDCK
T16823 36104-36107 CC denotes and
T16822 36096-36103 CD denotes HEK293T
T16821 36083-36095 NN denotes transfection
T16820 36079-36082 CC denotes and
T16819 36073-36078 NNS denotes Cells
T17718 38828-38829 . denotes .
T17717 38827-38828 -RRB- denotes )
T17716 38826-38827 CD denotes 0
T17715 38821-38825 NN denotes time
T17714 38819-38820 SYM denotes =
T17713 38817-38818 -LRB- denotes (
T17712 38812-38816 NN denotes lane
T17711 38806-38811 JJ denotes first
T17710 38802-38805 DT denotes the
T17709 38799-38801 TO denotes to
T17605 38207-38210 CC denotes and
T17604 38202-38206 NNP denotes EDTA
T17603 38199-38201 NNP denotes mM
T17602 38195-38198 CD denotes 0.5
T17601 38193-38194 , denotes ,
T17600 38185-38193 NN denotes glycerol
T17599 38183-38184 NN denotes %
T17598 38181-38183 CD denotes 20
T17597 38179-38180 , denotes ,
T17596 38174-38179 NNP denotes MgCl2
T17595 38171-38173 NNP denotes mM
T17594 38169-38170 CD denotes 1
T17593 38167-38168 , denotes ,
T17592 38164-38167 NNP denotes KCl
T17591 38161-38163 NNP denotes mM
T17590 38158-38160 CD denotes 10
T17589 38156-38157 , denotes ,
T17588 38152-38156 NNP denotes NaCl
T17587 38149-38151 NNP denotes mM
T17586 38145-38148 CD denotes 400
T17585 38143-38144 , denotes ,
T17584 38138-38143 NN denotes NP-40
T17583 38136-38137 NN denotes %
T17582 38135-38136 CD denotes 1
T17581 38133-38134 , denotes ,
T17580 38130-38133 CD denotes 7.5
T17579 38127-38129 NNP denotes pH
T17578 38121-38126 NNP denotes Hepes
T17577 38118-38120 NNP denotes mM
T17576 38115-38117 CD denotes 20
T17575 38114-38115 -LRB- denotes (
T17574 38111-38113 NN denotes B2
T17573 38108-38110 IN denotes in
T17572 38102-38107 VBN denotes lyzed
T17571 38098-38101 VBD denotes was
T17570 38091-38097 NN denotes pellet
T17569 38080-38090 VBG denotes containing
T17568 38071-38079 NN denotes fraction
T17567 38063-38070 JJ denotes nuclear
T17566 38059-38062 DT denotes The
T17565 38057-38058 . denotes .
T17564 38054-38057 NN denotes min
T17563 38052-38053 CD denotes 5
T17562 38048-38051 IN denotes for
T17561 38046-38047 NN denotes g
T17560 38042-38045 CD denotes 500
T17559 38039-38041 IN denotes at
T17558 38027-38038 VBN denotes centrifuged
T17557 38022-38026 VBD denotes were
T17556 38016-38021 NNS denotes cells
T17555 38012-38015 CC denotes and
T17554 38010-38011 NN denotes %
T17553 38006-38010 CD denotes 0.65
T17552 38003-38005 IN denotes of
T17551 37989-38002 NN denotes concentration
T17550 37983-37988 JJ denotes final
T17549 37981-37982 DT denotes a
T17548 37978-37980 TO denotes to
T17547 37972-37977 VBN denotes added
T17546 37968-37971 VBD denotes was
T17545 37958-37967 NN denotes detergent
T17544 37952-37957 NNP denotes NP-40
T17543 37950-37951 , denotes ,
T17542 37946-37950 NNP denotes Next
T17541 37943-37945 NNP denotes C.
T17540 37942-37943 CD denotes °
T17539 37941-37942 CD denotes 4
T17538 37938-37940 IN denotes at
T17537 37934-37937 NN denotes min
T17536 37931-37933 CD denotes 15
T17535 37927-37930 IN denotes for
T17534 37925-37926 -RRB- denotes )
T17533 37915-37925 NNS denotes inhibitors
T17532 37903-37914 NN denotes phosphatase
T17531 37899-37902 CC denotes and
T17530 37890-37898 NN denotes protease
T17529 37885-37889 IN denotes with
T17528 37872-37884 VBD denotes supplemented
T17527 37867-37871 NNP denotes EGTA
T17526 37864-37866 NNP denotes mM
T17525 37860-37863 CD denotes 0.1
T17524 37856-37859 CC denotes and
T17523 37851-37855 NNP denotes EDTA
T17522 37848-37850 NNP denotes mM
T17521 37844-37847 CD denotes 0.5
T17520 37842-37843 , denotes ,
T17519 37834-37842 NN denotes glycerol
T17518 37832-37833 NN denotes %
T17517 37831-37832 CD denotes 5
T17516 37829-37830 , denotes ,
T17515 37824-37829 NNP denotes MgCl2
T17514 37821-37823 NNP denotes mM
T17513 37819-37820 CD denotes 1
T17512 37817-37818 , denotes ,
T17511 37814-37817 NNP denotes KCl
T17510 37811-37813 NNP denotes mM
T17509 37808-37810 CD denotes 10
T17508 37806-37807 , denotes ,
T17507 37803-37806 CD denotes 7.5
T17506 37800-37802 NNP denotes pH
T17505 37794-37799 NNP denotes Hepes
T17504 37791-37793 NNP denotes mM
T17503 37788-37790 CD denotes 10
T17502 37787-37788 -LRB- denotes (
T17501 37784-37786 NNP denotes B1
T17500 37781-37783 IN denotes in
T17499 37775-37780 NNS denotes cells
T17498 37762-37774 VBG denotes resuspending
T17497 37759-37761 IN denotes by
T17496 37750-37758 VBN denotes prepared
T17495 37745-37749 VBD denotes were
T17494 37737-37744 NNS denotes lysates
T17493 37725-37736 JJ denotes cytoplasmic
T17492 37721-37724 CC denotes and
T17491 37713-37720 NNP denotes Nuclear
T17490 37711-37712 . denotes .
T17489 37701-37711 NNS denotes inhibitors
T17488 37689-37700 NN denotes phosphatase
T17487 37685-37688 CC denotes and
T17486 37676-37684 NN denotes protease
T17485 37671-37675 IN denotes with
T17484 37658-37670 VBN denotes supplemented
T17483 37656-37657 -RRB- denotes )
T17482 37653-37656 NNP denotes DTT
T17481 37650-37652 NNP denotes mM
T17480 37648-37649 CD denotes 2
T17479 37646-37647 , denotes ,
T17478 37642-37646 NNP denotes EDTA
T17477 37639-37641 NNP denotes mM
T17476 37637-37638 CD denotes 5
T17475 37635-37636 , denotes ,
T17474 37632-37635 CD denotes 7.5
T17473 37629-37631 NNP denotes pH
T17472 37620-37628 NNP denotes Tris-HCl
T17471 37617-37619 NNP denotes mM
T17470 37614-37616 CD denotes 10
T17469 37612-37613 , denotes ,
T17468 37607-37612 NN denotes NP-40
T17467 37605-37606 NN denotes %
T17466 37604-37605 CD denotes 1
T17465 37602-37603 , denotes ,
T17464 37598-37602 NNP denotes NaCl
T17463 37595-37597 NNP denotes mM
T17462 37591-37594 CD denotes 200
T17461 37590-37591 -LRB- denotes (
T17460 37583-37589 NN denotes buffer
T17459 37577-37582 NN denotes lysis
T17458 37574-37576 IN denotes in
T17457 37570-37573 NN denotes min
T17456 37567-37569 CD denotes 15
T17455 37563-37566 IN denotes for
T17454 37561-37562 NNP denotes C
T17453 37560-37561 CD denotes °
T17452 37559-37560 CD denotes 4
T17451 37556-37558 IN denotes at
T17450 37550-37555 VBN denotes lysed
T17449 37545-37549 VBD denotes were
T17448 37539-37544 NNS denotes cells
T17447 37537-37538 , denotes ,
T17446 37530-37537 NNS denotes lysates
T17445 37524-37529 JJ denotes total
T17444 37520-37523 IN denotes For
T17443 37511-37519 VBG denotes blotting
T17442 37503-37510 JJ denotes Western
T17708 38790-38798 JJ denotes relative
T17707 38779-38789 VBN denotes calculated
T17706 38774-38778 VBD denotes were
T17705 38762-38773 NNS denotes intensities
T17704 38758-38761 DT denotes All
T17703 38756-38757 . denotes .
T17702 38752-38756 NN denotes tool
T17701 38743-38751 NN denotes analyzer
T17700 38739-38742 NNP denotes Gel
T17699 38737-38738 -RRB- denotes )
T17698 38713-38737 NNP denotes http://rsbweb.nih.gov/ij
T17697 38712-38713 -LRB- denotes (
T17696 38705-38711 NNP denotes ImageJ
T17695 38701-38704 DT denotes the
T17694 38696-38700 IN denotes with
T17693 38694-38695 -RRB- denotes )
T17692 38685-38694 NN denotes induction
T17691 38680-38684 VB denotes fold
T17690 38679-38680 -LRB- denotes (
T17689 38668-38678 VBN denotes quantified
T17688 38664-38667 VBD denotes was
T17687 38658-38663 NNS denotes bands
T17686 38654-38657 DT denotes the
T17685 38651-38653 IN denotes of
T17684 38643-38650 NN denotes density
T17683 38639-38642 DT denotes The
T17682 38637-38638 . denotes .
T17681 38636-38637 -RRB- denotes )
T17680 38625-38636 NNPS denotes Biomedicals
T17679 38622-38624 NNP denotes MP
T17678 38621-38622 -LRB- denotes (
T17677 38610-38620 JJ denotes anti-actin
T17676 38606-38609 CC denotes and
T17675 38604-38605 -RRB- denotes )
T17674 38595-38604 NNP denotes Signaling
T17673 38590-38594 NNP denotes Cell
T17672 38589-38590 -LRB- denotes (
T17671 38571-38588 JJ denotes anti-phospho-IκBα
T17670 38567-38570 CC denotes and
T17669 38549-38566 JJ denotes anti-phospho-IRF3
T17668 38547-38548 , denotes ,
T17667 38546-38547 -RRB- denotes )
T17666 38536-38546 NNP denotes Invitrogen
T17665 38535-38536 -LRB- denotes (
T17664 38525-38534 JJ denotes anti-IRF3
T17663 38523-38524 , denotes ,
T17662 38522-38523 -RRB- denotes )
T17661 38518-38522 NNP denotes Cruz
T17660 38512-38517 NNP denotes Santa
T17659 38511-38512 -LRB- denotes (
T17658 38508-38510 NNP denotes H1
T17657 38496-38507 JJ denotes anti-histon
T17656 38492-38495 CC denotes and
T17655 38490-38491 , denotes ,
T17654 38482-38490 JJ denotes anti-p65
T17653 38480-38481 , denotes ,
T17652 38471-38480 JJ denotes anti-IκBα
T17651 38469-38470 , denotes ,
T17650 38461-38469 JJ denotes anti-A20
T17649 38456-38460 IN denotes with
T17648 38447-38455 VBN denotes revealed
T17647 38442-38446 VBD denotes were
T17646 38430-38441 NNS denotes Immunoblots
T17645 38428-38429 . denotes .
T17644 38427-38428 -RRB- denotes )
T17643 38419-38427 NNPS denotes Sciences
T17642 38414-38418 NNP denotes Life
T17641 38408-38413 NNP denotes Elmer
T17640 38401-38407 NNP denotes Perkin
T17639 38400-38401 -LRB- denotes (
T17638 38390-38399 NN denotes detection
T17637 38386-38389 NNP denotes ECL
T17636 38382-38385 CC denotes and
T17635 38373-38381 VBG denotes blotting
T17634 38365-38372 JJ denotes western
T17633 38362-38364 IN denotes by
T17632 38353-38361 VBN denotes analyzed
T17631 38349-38352 CC denotes and
T17630 38340-38348 NNP denotes SDS-PAGE
T17629 38337-38339 IN denotes by
T17628 38327-38336 VBN denotes separated
T17627 38314-38326 RB denotes subsequently
T17626 38309-38313 VBD denotes were
T17625 38301-38308 NNS denotes lysates
T17624 38297-38300 DT denotes The
T17623 38295-38296 . denotes .
T17622 38294-38295 NNP denotes C
T17621 38293-38294 CD denotes °
T17620 38292-38293 CD denotes 4
T17619 38289-38291 IN denotes at
T17618 38285-38288 NN denotes min
T17617 38282-38284 CD denotes 15
T17616 38278-38281 IN denotes for
T17615 38276-38277 -RRB- denotes )
T17614 38266-38276 NNS denotes inhibitors
T17613 38254-38265 NN denotes phosphatase
T17612 38250-38253 CC denotes and
T17611 38241-38249 NN denotes protease
T17610 38236-38240 IN denotes with
T17609 38223-38235 VBD denotes supplemented
T17608 38218-38222 NNP denotes EGTA
T17607 38215-38217 NNP denotes mM
T17606 38211-38214 CD denotes 0.1
T16404 36070-36071 . denotes .
T16403 36065-36070 NNS denotes cells
T16402 36060-36064 JJ denotes dead
T16401 36055-36059 IN denotes from
T16400 36050-36054 JJ denotes live
T16399 36037-36049 JJ denotes discriminate
T16398 36034-36036 TO denotes to
T16397 36029-36033 VBN denotes used
T16396 36025-36028 VBD denotes was
T16395 36023-36024 -RRB- denotes )
T16394 36017-36023 NNS denotes Probes
T16393 36007-36016 JJ denotes Molecular
T16392 36006-36007 -LRB- denotes (
T16391 36002-36005 NN denotes kit
T16390 35996-36001 VB denotes stain
T16389 35991-35995 NN denotes cell
T16388 35986-35990 JJ denotes dead
T16387 35981-35985 NN denotes aqua
T16925 36666-36668 NNP denotes J.
T16924 36663-36665 IN denotes by
T16923 36654-36662 VBN denotes provided
T16922 36647-36653 RB denotes kindly
T16921 36646-36647 -LRB- denotes (
T16920 36631-36645 JJ denotes pGL3-IFNα4-luc
T16919 36629-36630 , denotes ,
T16918 36628-36629 -RRB- denotes )
T16917 36620-36628 NNP denotes LMBP4011
T16916 36619-36620 -LRB- denotes (
T16915 36609-36618 NNP denotes pISRE-luc
T16914 36607-36608 , denotes ,
T16913 36606-36607 -RRB- denotes )
T16912 36598-36606 NNP denotes LMBP3248
T16911 36597-36598 -LRB- denotes (
T16910 36589-36596 NNP denotes pConLuc
T16909 36576-36588 RB denotes respectively
T16908 36575-36576 -LRB- denotes (
T16907 36566-36574 NNS denotes plasmids
T16906 36557-36565 NN denotes reporter
T16905 36552-36556 NNP denotes IRF7
T16904 36550-36551 , denotes ,
T16903 36546-36550 NNP denotes IRF3
T16902 36544-36545 , denotes ,
T16901 36539-36544 NNP denotes NF-κB
T16900 36537-36538 , denotes ,
T16899 36536-36537 -RRB- denotes )
T16898 36535-36536 -RRB- denotes )
T16897 36530-36535 NNP denotes Tokyo
T16896 36527-36529 IN denotes of
T16895 36516-36526 NNP denotes University
T16894 36514-36515 , denotes ,
T16893 36506-36514 NNP denotes Medicine
T16892 36503-36505 IN denotes of
T16891 36495-36502 NNP denotes Faculty
T16890 36491-36494 CC denotes and
T16889 36482-36490 NNP denotes Medicine
T16888 36479-36481 IN denotes of
T16887 36472-36478 NNP denotes School
T16886 36463-36471 NNP denotes Graduate
T16885 36461-36462 , denotes ,
T16884 36452-36461 NNP denotes Taniguchi
T16883 36449-36451 NNP denotes T.
T16882 36446-36448 IN denotes by
T16881 36437-36445 VBN denotes provided
T16880 36430-36436 RB denotes kindly
T16879 36429-36430 -LRB- denotes (
T16878 36416-36428 NNP denotes pEF-HA-IRF-7
T16877 36414-36415 , denotes ,
T16876 36413-36414 -RRB- denotes )
T16875 36409-36413 CD denotes 6517
T16874 36404-36408 NNP denotes LMBP
T16873 36403-36404 -LRB- denotes (
T16872 36383-36402 NNP denotes pCAGGS-E-RIG-I-CARD
T16871 36381-36382 , denotes ,
T16870 36380-36381 -RRB- denotes )
T16869 36376-36380 CD denotes 3778
T16868 36371-36375 NNP denotes LMBP
T16867 36370-36371 -LRB- denotes (
T16866 36356-36369 NN denotes pCAGGS-E-hA20
T16865 36355-36356 -LRB- denotes (
T16864 36347-36354 NNS denotes vectors
T16863 36336-36346 NN denotes expression
T16862 36327-36335 JJ denotes specific
T16861 36322-36326 IN denotes with
T16860 36315-36321 NN denotes method
T16859 36302-36314 NN denotes transfection
T16858 36290-36301 NN denotes precipitate
T16857 36280-36289 NN denotes phosphate
T16856 36272-36279 NN denotes calcium
T16855 36268-36271 DT denotes the
T16854 36262-36267 VBG denotes using
T16853 36250-36261 VBN denotes transfected
T16852 36245-36249 VBD denotes were
T16851 36239-36244 NNS denotes cells
T16850 36231-36238 CD denotes HEK293T
T16849 36229-36230 . denotes .
T16848 36218-36229 NNS denotes antibiotics
T16847 36214-36217 CC denotes and
T16846 36205-36213 NN denotes pyruvate
T16845 36198-36204 NN denotes sodium
T16844 36195-36197 NNP denotes mM
T16843 36191-36194 CD denotes 0.4
T16842 36189-36190 , denotes ,
T16841 36178-36189 NNP denotes L-glutamine
T16840 36175-36177 NNP denotes mM
T16839 36173-36174 CD denotes 2
T16838 36171-36172 , denotes ,
T16837 36168-36171 NNP denotes FCS
T16836 36166-36167 NN denotes %
T16835 36164-36166 CD denotes 10
T16834 36159-36163 IN denotes with
T16833 36146-36158 VBN denotes supplemented
T16832 36144-36145 -RRB- denotes )
T16831 36139-36144 NNP denotes Gibco
T16830 36138-36139 -LRB- denotes (
T16829 36133-36137 NNP denotes DMEM
T16828 36130-36132 IN denotes in
T16386 35973-35980 JJ denotes fixable
T16385 35963-35972 JJ denotes Live/Dead
T16384 35961-35962 . denotes .
T16383 35951-35961 NN denotes expression
T16382 35949-35950 VBP denotes +
T16381 35946-35949 NNP denotes CD8
T16380 35942-35945 CC denotes and
T16379 35940-35941 NNP denotes +
T16378 35937-35940 NNP denotes CD3
T16377 35930-35936 NNP denotes CD62lo
T16376 35927-35929 IN denotes on
T16375 35921-35926 VBN denotes based
T16374 35911-35920 NN denotes cytometry
T16373 35906-35910 NN denotes flow
T16372 35903-35905 IN denotes by
T16371 35894-35902 VBN denotes analyzed
T16370 35889-35893 VBD denotes were
T16369 35883-35888 NNS denotes cells
T16368 35881-35882 NNP denotes T
T16367 35879-35880 CD denotes +
T16366 35876-35879 CD denotes CD8
T16365 35866-35875 VBN denotes Activated
T16364 35864-35865 . denotes .
T16363 35852-35864 NNS denotes instructions
T16362 35849-35851 POS denotes 's
T16361 35837-35849 NN denotes manufacturer
T16013 35221-35223 IN denotes of
T16012 35213-35220 RB denotes instead
T16011 35209-35212 CD denotes PR8
T16010 35206-35208 CC denotes or
T16009 35204-35205 -RRB- denotes )
T16008 35197-35204 NN denotes control
T16007 35183-35196 NN denotes agglutination
T15958 34940-34942 IN denotes of
T15957 34933-34939 NN denotes series
T15956 34924-34932 NN denotes dilution
T15955 34915-34923 JJ denotes two-fold
T15954 34913-34914 DT denotes a
T15953 34902-34912 VBG denotes incubating
T15952 34899-34901 IN denotes by
T15951 34894-34898 VBN denotes done
T15950 34890-34893 VBD denotes was
T15949 34880-34889 NNP denotes Titration
T15948 34878-34879 . denotes .
T15947 34875-34878 NNP denotes RBC
T15946 34867-34874 NN denotes chicken
T15945 34865-34866 NN denotes %
T15944 34863-34865 CD denotes 50
T15943 34856-34862 NN denotes volume
T15942 34851-34855 CD denotes 1/10
T15941 34846-34850 IN denotes with
T15940 34838-34845 VBN denotes cleared
T15939 34833-34837 VBD denotes were
T15938 34828-34832 NN denotes sera
T15937 34826-34827 , denotes ,
T15936 34818-34826 NNS denotes proteins
T15935 34810-34817 JJ denotes binding
T15934 34805-34809 NN denotes acid
T15933 34798-34804 JJ denotes sialic
T15932 34791-34797 VB denotes remove
T15931 34788-34790 TO denotes To
T15930 34786-34787 . denotes .
T15929 34783-34786 NN denotes min
T15928 34780-34782 CD denotes 30
T15927 34776-34779 IN denotes for
T15926 34774-34775 NNP denotes C
T15925 34773-34774 CD denotes °
T15924 34771-34773 CD denotes 56
T15923 34768-34770 TO denotes to
T15922 34760-34767 NN denotes heating
T15921 34756-34759 CC denotes and
T15920 34752-34755 NNP denotes PBS
T15919 34749-34751 IN denotes in
T15918 34741-34748 NN denotes citrate
T15917 34734-34740 NN denotes sodium
T15916 34732-34733 NN denotes %
T15915 34728-34732 CD denotes 0.75
T15914 34725-34727 IN denotes of
T15913 34716-34724 NN denotes addition
T15912 34713-34715 IN denotes by
T15911 34701-34712 VBN denotes inactivated
T15910 34697-34700 VBD denotes was
T15909 34693-34696 NNP denotes RDE
T15908 34689-34692 DT denotes the
T15907 34687-34688 , denotes ,
T15906 34686-34687 NNP denotes C
T15905 34685-34686 CD denotes °
T15904 34683-34685 CD denotes 37
T15903 34680-34682 IN denotes at
T15902 34670-34679 JJ denotes overnight
T15901 34659-34669 NN denotes incubation
T15900 34653-34658 IN denotes After
T15899 34651-34652 . denotes .
T15898 34638-34651 NN denotes agglutination
T15897 34635-34637 IN denotes of
T15896 34624-34634 NN denotes inhibition
T15895 34614-34623 JJ denotes aspecific
T15894 34611-34613 IN denotes of
T15893 34603-34610 JJ denotes capable
T16360 35833-35836 DT denotes the
T16359 35830-35832 TO denotes to
T16358 35820-35829 VBG denotes according
T16357 35818-35819 -RRB- denotes )
T16356 35807-35818 NNP denotes Biosciences
T16355 35804-35806 NNP denotes BD
T16354 35802-35803 , denotes ,
T16353 35786-35802 NNP denotes Cytofix/Cytoperm
T16352 35785-35786 -LRB- denotes (
T16351 35771-35784 VBN denotes permeabilized
T16350 35767-35770 CC denotes and
T16349 35761-35766 VBN denotes fixed
T16348 35759-35760 , denotes ,
T16347 35752-35759 VBN denotes stained
T16346 35747-35751 VBD denotes were
T16345 35741-35746 NNP denotes Cells
T16344 35738-35740 NNP denotes A.
T16343 35728-35737 NNP denotes Brefeldin
T16342 35725-35727 NN denotes ml
T16341 35724-35725 NN denotes /
T16340 35722-35724 NN denotes µg
T16339 35720-35721 CD denotes 3
T16338 35717-35719 IN denotes of
T16337 35708-35716 NN denotes presence
T16336 35704-35707 DT denotes the
T16335 35701-35703 IN denotes in
T16334 35696-35700 NN denotes lung
T16333 35692-35695 DT denotes the
T16332 35687-35691 IN denotes from
T16331 35678-35686 VBN denotes prepared
T16330 35673-35677 VBD denotes were
T16329 35661-35672 NNS denotes suspensions
T16328 35656-35660 NN denotes cell
T16327 35649-35655 JJ denotes single
T16326 35645-35648 CC denotes and
T16325 35636-35644 VBN denotes isolated
T16324 35631-35635 VBD denotes were
T16323 35625-35630 NNS denotes lungs
T16322 35621-35624 CC denotes and
T16321 35617-35620 NNP denotes BAL
T16320 35615-35616 , denotes ,
T16319 35610-35615 RB denotes later
T16318 35608-35609 NN denotes h
T16317 35606-35607 CD denotes 6
T16316 35604-35605 . denotes .
T16315 35603-35604 NNP denotes ]
T16314 35601-35603 CD denotes 86
T16313 35600-35601 NNP denotes [
T16312 35590-35599 VBN denotes described
T16311 35579-35589 RB denotes previously
T16310 35576-35578 IN denotes as
T16309 35574-35575 -RRB- denotes )
T16308 35569-35574 NNP denotes Sigma
T15575 34026-34035 VBN denotes incubated
T15574 34021-34025 VBD denotes were
T15573 34009-34020 NNS denotes homogenates
T15572 34004-34008 NN denotes lung
T15571 34001-34003 IN denotes of
T15570 33991-34000 NNS denotes dilutions
T15569 33984-33990 JJ denotes serial
T15568 33973-33983 JJ denotes Eight-fold
T15567 33971-33972 . denotes .
T15566 33968-33971 NNP denotes PBS
T15565 33965-33967 IN denotes in
T15564 33963-33964 -RRB- denotes )
T15563 33953-33963 NNP denotes Kinematica
T15562 33952-33953 -LRB- denotes (
T15561 33940-33951 NN denotes homogenizer
T15560 33931-33939 NNP denotes Polytron
T15559 33929-33930 DT denotes a
T15558 33924-33928 IN denotes with
T15557 33912-33923 VBN denotes homogenized
T15556 33907-33911 VBD denotes were
T15555 33901-33906 NNS denotes lungs
T15554 33899-33900 : denotes :
T15553 33892-33899 VBZ denotes follows
T15552 33889-33891 IN denotes as
T15551 33880-33888 VBN denotes measured
T15550 33876-33879 VBD denotes was
T15549 33874-33875 -RRB- denotes )
T15548 33868-33874 CD denotes TCID50
T15547 33867-33868 -LRB- denotes (
T15546 33862-33866 NN denotes dose
T15545 33851-33861 JJ denotes infectious
T15544 33843-33850 NN denotes culture
T15543 33836-33842 NN denotes tissue
T15542 33829-33835 JJ denotes median
T15504 33616-33617 -RRB- denotes )
T15503 33611-33616 NN denotes mg/kg
T15502 33608-33610 CD denotes 12
T15501 33607-33608 -LRB- denotes (
T15500 33598-33606 NN denotes ketamine
T15499 33593-33597 IN denotes with
T15498 33583-33592 NN denotes injection
T15497 33578-33582 JJ denotes i.p.
T15496 33575-33577 IN denotes by
T15495 33562-33574 JJ denotes anesthetized
T15494 33557-33561 VBD denotes were
T15493 33552-33556 NNS denotes mice
T15492 33550-33551 , denotes ,
T15491 33539-33550 NN denotes inoculation
T15490 33533-33538 JJ denotes viral
T15489 33529-33532 IN denotes For
T15488 33527-33528 . denotes .
T15487 33522-33527 NNS denotes cells
T15486 33517-33521 NNP denotes MDCK
T15485 33514-33516 IN denotes in
T16006 35182-35183 -LRB- denotes (
T16005 35176-35181 NN denotes serum
T16004 35169-35175 JJ denotes immune
T16003 35166-35168 IN denotes of
T16002 35158-35165 RB denotes instead
T16001 35154-35157 NNP denotes PBS
T16000 35145-35153 VBD denotes included
T15999 35136-35144 NNS denotes controls
T15998 35127-35135 JJ denotes Negative
T15997 35125-35126 . denotes .
T15996 35120-35125 RB denotes later
T15995 35116-35119 NN denotes min
T15994 35113-35115 CD denotes 30
T15993 35108-35112 VBN denotes read
T15992 35103-35107 VBD denotes were
T15991 35096-35102 NNS denotes titers
T15990 35092-35095 CC denotes and
T15989 35086-35091 VBN denotes added
T15988 35082-35085 VBD denotes was
T15987 35078-35081 NNP denotes RBC
T15986 35070-35077 NN denotes chicken
T15985 35068-35069 NN denotes %
T15984 35065-35068 CD denotes 0.5
T15983 35062-35064 IN denotes of
T15982 35055-35061 NN denotes volume
T15981 35049-35054 JJ denotes equal
T15980 35046-35048 DT denotes an
T15979 35044-35045 , denotes ,
T15978 35037-35044 RB denotes Finally
T15977 35035-35036 . denotes .
T15976 35029-35035 NNS denotes plates
T15975 35020-35028 NN denotes U-bottom
T15974 35012-35019 JJ denotes 96-well
T15973 35009-35011 IN denotes in
T15972 34997-35008 NN denotes temperature
T15971 34992-34996 NN denotes room
T15970 34989-34991 IN denotes at
T15969 34984-34988 NN denotes hour
T15968 34982-34983 CD denotes 1
T15967 34978-34981 IN denotes for
T15966 34972-34977 NN denotes virus
T15965 34967-34971 NNP denotes X-47
T15964 34964-34966 IN denotes of
T15963 34958-34963 NNS denotes units
T15962 34955-34957 NNP denotes HA
T15961 34953-34954 CD denotes 4
T15960 34948-34952 IN denotes with
T15959 34943-34947 NN denotes sera
T15240 33395-33396 . denotes .
T15239 33383-33395 RB denotes respectively
T15238 33381-33382 -RRB- denotes )
T15237 33371-33381 NN denotes A20myel-WT
T15236 33370-33371 -LRB- denotes (
T15235 33365-33369 NN denotes type
T15234 33360-33364 JJ denotes wild
T15233 33356-33359 CC denotes and
T15232 33345-33355 JJ denotes A20myel-KO
T15231 33338-33344 VBN denotes termed
T15230 33333-33337 VBD denotes were
T15229 33323-33332 NN denotes transgene
T15228 33314-33322 NNP denotes LysM-Cre
T15227 33310-33313 DT denotes the
T15226 33302-33309 VBG denotes lacking
T15225 33299-33301 CC denotes or
T15224 33288-33298 VBG denotes expressing
T15223 33283-33287 NNS denotes mice
T15222 33274-33282 JJ denotes A20fl/fl
T15221 33272-33273 . denotes .
T15220 33262-33272 NN denotes background
T15219 33254-33261 NNP denotes C57Bl/6
T15218 33250-33253 DT denotes the
T15217 33247-33249 TO denotes to
T15216 33241-33246 NNS denotes times
T15215 33235-33240 CD denotes three
T15214 33223-33234 VBN denotes backcrossed
T15213 33218-33222 VBD denotes were
T15212 33210-33217 NNS denotes animals
T15211 33201-33209 NNP denotes LysM-Cre
T15210 33192-33200 NNP denotes A20fl/fl
T15209 33190-33191 . denotes .
T15208 33179-33190 NNS denotes littermates
T15207 33167-33178 JJ denotes sex-matched
T15206 33163-33166 CC denotes and
T15205 33161-33162 -RRB- denotes )
T15204 33158-33161 JJ denotes old
T15203 33152-33157 NNS denotes weeks
T15202 33150-33151 CD denotes 9
T15201 33146-33149 CC denotes and
T15200 33144-33145 CD denotes 7
T15199 33136-33143 IN denotes between
T15198 33135-33136 -LRB- denotes (
T15197 33133-33134 : denotes -
T15196 33130-33133 NN denotes age
T15195 33127-33129 IN denotes on
T15194 33117-33126 VBN denotes performed
T15193 33112-33116 VBD denotes were
T15192 33101-33111 NNS denotes infections
T15191 33091-33100 NNP denotes Influenza
T15190 33089-33090 . denotes .
T15189 33079-33089 NNS denotes facilities
T15188 33072-33078 NN denotes animal
T15187 33058-33071 JJ denotes pathogen-free
T15186 33049-33057 JJ denotes specific
T15185 33046-33048 IN denotes in
T15184 33037-33045 NNP denotes Research
T15183 33026-33036 NNP denotes Biomedical
T15182 33016-33025 NNP denotes Molecular
T15181 33013-33015 IN denotes of
T15180 33002-33012 NNP denotes Department
T15179 32998-33001 NNP denotes VIB
T15178 32994-32997 DT denotes the
T15177 32991-32993 IN denotes at
T15176 32985-32990 NNS denotes cages
T15175 32974-32984 VBN denotes ventilated
T15174 32961-32973 RB denotes individually
T15173 32958-32960 IN denotes in
T15172 32951-32957 VBN denotes housed
T15171 32946-32950 VBD denotes were
T15170 32941-32945 NNS denotes Mice
T15169 32939-32940 . denotes .
T15168 32938-32939 NNP denotes ]
T15167 32936-32938 CD denotes 48
T15166 32935-32936 NNP denotes [
T15165 32925-32934 RB denotes elsewhere
T15164 32918-32924 NN denotes detail
T15163 32915-32917 IN denotes in
T15162 32905-32914 VBN denotes described
T15161 32901-32904 VBP denotes are
T15160 32897-32900 CC denotes and
T15159 32886-32896 NNS denotes transgenes
T15158 32878-32885 NNP denotes LysMCre
T15157 32869-32877 NNP denotes A20fl/fl
T15156 32860-32868 VB denotes generate
T15155 32857-32859 TO denotes to
T15154 32855-32856 -RRB- denotes )
T15153 32848-32855 NNP denotes Germany
T15152 32846-32847 , denotes ,
T15151 32839-32846 NNP denotes Cologne
T15150 32836-32838 IN denotes of
T15149 32825-32835 NNP denotes University
T15148 32823-32824 , denotes ,
T15147 32815-32823 NNP denotes Genetics
T15146 32812-32814 IN denotes of
T15145 32802-32811 NNP denotes Institute
T15144 32800-32801 , denotes ,
T15143 32793-32800 NNP denotes Förster
T15142 32790-32792 NN denotes I.
T15141 32787-32789 IN denotes by
T15643 34364-34365 . denotes .
T15642 34363-34364 NNP denotes ]
T15641 34361-34363 CD denotes 85
T15640 34360-34361 NNP denotes [
T15639 34353-34359 NNP denotes Muench
T15638 34349-34352 CC denotes and
T15637 34344-34348 NNP denotes Reed
T15636 34341-34343 IN denotes of
T15635 34334-34340 NN denotes method
T15634 34330-34333 DT denotes the
T15633 34327-34329 TO denotes to
T15632 34317-34326 VBG denotes according
T15631 34306-34316 VBN denotes calculated
T15630 34301-34305 RB denotes then
T15629 34296-34300 VBD denotes were
T15628 34289-34295 NNS denotes titers
T15627 34282-34288 CD denotes TCID50
T15626 34280-34281 . denotes .
T15625 34271-34280 VBN denotes monitored
T15624 34267-34270 VBD denotes was
T15623 34250-34266 NN denotes hemagglutination
T15622 34247-34249 IN denotes of
T15621 34238-34246 NN denotes dilution
T15620 34228-34237 JJ denotes end-point
T15619 34224-34227 CC denotes and
T15618 34218-34223 VBN denotes added
T15617 34213-34217 VBD denotes were
T15616 34211-34212 -RRB- denotes )
T15615 34208-34211 NNP denotes RBC
T15614 34207-34208 -LRB- denotes (
T15613 34201-34206 NNS denotes cells
T15612 34195-34200 NN denotes blood
T15611 34191-34194 JJ denotes red
T15610 34183-34190 NN denotes chicken
T15609 34181-34182 NN denotes %
T15608 34178-34181 CD denotes 0.5
T15607 34176-34177 , denotes ,
T15606 34168-34176 JJ denotes read-out
T15605 34164-34167 IN denotes For
T15604 34162-34163 . denotes .
T15603 34151-34162 NNS denotes antibiotics
T15602 34147-34150 CC denotes and
T15601 34138-34146 NN denotes pyruvate
T15600 34131-34137 NN denotes sodium
T15599 34128-34130 NNP denotes mM
T15598 34124-34127 CD denotes 0.4
T15597 34122-34123 , denotes ,
T15596 34111-34122 NNP denotes L-glutamine
T15595 34108-34110 NNP denotes mM
T15594 34106-34107 CD denotes 2
T15593 34104-34105 , denotes ,
T15592 34103-34104 -RRB- denotes )
T15591 34101-34103 NN denotes ml
T15590 34100-34101 NN denotes /
T15589 34098-34100 NN denotes µg
T15588 34096-34097 CD denotes 1
T15587 34095-34096 -LRB- denotes (
T15586 34087-34094 NN denotes trypsin
T15585 34082-34086 IN denotes with
T15584 34069-34081 VBN denotes supplemented
T15583 34064-34068 NNP denotes DMEM
T15582 34061-34063 IN denotes in
T15581 34056-34060 NNS denotes days
T15580 34054-34055 CD denotes 5
T15579 34050-34053 IN denotes for
T15578 34044-34049 NNS denotes cells
T15577 34039-34043 NNP denotes MDCK
T15576 34036-34038 IN denotes on
T15140 32778-32786 VBN denotes provided
T15139 32777-32778 -LRB- denotes (
T15138 32775-32776 NNP denotes ]
T15137 32773-32775 CD denotes 84
T15136 32772-32773 NNP denotes [
T15135 32767-32771 NNS denotes mice
T15134 32758-32766 NNP denotes LysM-Cre
T15133 32753-32757 IN denotes with
T15132 32745-32752 VBN denotes crossed
T15131 32740-32744 VBD denotes were
T15130 32735-32739 NNS denotes mice
T15129 32726-32734 JJ denotes A20fl/fl
T15128 32724-32725 . denotes .
T15127 32723-32724 NNP denotes ]
T15126 32721-32723 CD denotes 56
T15125 32720-32721 NNP denotes [
T15124 32710-32719 VBN denotes described
T15123 32699-32709 RB denotes previously
T15122 32696-32698 IN denotes as
T15121 32686-32695 VBN denotes generated
T15120 32681-32685 VBD denotes were
T15119 32676-32680 NNS denotes mice
T15118 32667-32675 NNP denotes A20fl/fl
T15117 32662-32666 NNP denotes Mice
T14981 32659-32660 . denotes .
T14980 32658-32659 -RRB- denotes )
T14979 32653-32658 NN denotes mg/kg
T14978 32650-32652 CD denotes 60
T14977 32649-32650 -LRB- denotes (
T14976 32640-32648 NN denotes xylazine
T14975 32636-32639 CC denotes and
T14974 32634-32635 -RRB- denotes )
T14973 32629-32634 NN denotes mg/kg
T14972 32626-32628 CD denotes 12
T14971 32625-32626 -LRB- denotes (
T14970 32616-32624 NN denotes ketamine
T14969 32613-32615 IN denotes of
T14968 32605-32612 NN denotes mixture
T14967 32603-32604 DT denotes a
T14966 32600-32602 IN denotes of
T14965 32590-32599 NN denotes injection
T14964 32588-32589 -RRB- denotes )
T14963 32584-32588 FW denotes i.p.
T14962 32583-32584 -LRB- denotes (
T14961 32567-32582 JJ denotes intraperitoneal
T14960 32564-32566 IN denotes by
T14959 32551-32563 JJ denotes anesthetized
T14958 32546-32550 VBD denotes were
T14957 32541-32545 NNS denotes Mice
T14956 32539-32540 . denotes .
T14955 32532-32539 NNS denotes animals
T14954 32529-32531 IN denotes of
T14953 32519-32528 NN denotes suffering
T14952 32508-32518 VB denotes ameliorate
T14951 32505-32507 TO denotes to
T14950 32500-32504 VBN denotes made
T14949 32495-32499 VBD denotes were
T14948 32487-32494 NNS denotes efforts
T14947 32483-32486 DT denotes All
T14946 32481-32482 . denotes .
T14945 32480-32481 -RRB- denotes )
T14944 32472-32480 CD denotes 2010/001
T14943 32469-32471 NNP denotes ID
T14942 32460-32468 NN denotes approval
T14941 32458-32459 , denotes ,
T14940 32449-32458 NNP denotes LA1400091
T14939 32442-32448 NN denotes number
T14938 32435-32441 VBP denotes permit
T14937 32434-32435 -LRB- denotes (
T14936 32423-32433 NNP denotes University
T14935 32417-32422 NNP denotes Ghent
T14934 32414-32416 IN denotes of
T14933 32404-32413 NN denotes committee
T14932 32397-32403 NNS denotes ethics
T14931 32393-32396 DT denotes the
T14930 32390-32392 IN denotes by
T14929 32381-32389 VBN denotes approved
T14928 32376-32380 VBD denotes were
T14927 32366-32375 NNS denotes protocols
T14926 32359-32365 NNP denotes Animal
T14925 32357-32358 . denotes .
T14924 32346-32357 NNS denotes regulations
T14923 32339-32345 NN denotes animal
T14922 32337-32338 -RRB- denotes )
T14921 32327-32337 NNP denotes 86/609/EEG
T14920 32325-32326 , denotes ,
T14919 32315-32325 NNP denotes 2010/63/EU
T14918 32304-32314 NNPS denotes Directives
T14917 32301-32303 NNP denotes EU
T14916 32300-32301 -LRB- denotes (
T14915 32291-32299 JJ denotes European
T14914 32287-32290 CC denotes and
T14913 32285-32286 -RRB- denotes )
T14912 32275-32285 CD denotes 06/04/2010
T14911 32268-32274 NNP denotes Decree
T14910 32262-32267 NNP denotes Royal
T14909 32254-32261 JJ denotes Belgian
T14908 32252-32253 , denotes ,
T14907 32242-32252 CD denotes 22/12/2003
T14906 32238-32241 CC denotes and
T14905 32227-32237 CD denotes 14/08/1986
T14904 32223-32226 NN denotes Law
T14903 32215-32222 JJ denotes Belgian
T14902 32214-32215 -LRB- denotes (
T14901 32205-32213 JJ denotes national
T14900 32201-32204 DT denotes the
T14899 32198-32200 TO denotes to
T14898 32188-32197 VBG denotes according
T14897 32178-32187 VBN denotes conducted
T14896 32173-32177 VBD denotes were
T14895 32168-32172 NNS denotes mice
T14894 32165-32167 IN denotes on
T14893 32153-32164 NNS denotes experiments
T14892 32149-32152 DT denotes All
T14891 32139-32148 NN denotes statement
T14890 32132-32138 NNS denotes Ethics
T14244 32006-32011 MD denotes might
T14243 32002-32005 NNP denotes A20
T14242 31999-32001 IN denotes of
T14241 31989-31998 VBG denotes targeting
T14240 31981-31988 JJ denotes similar
T14239 31979-31980 , denotes ,
T14238 31972-31979 RB denotes Finally
T14237 31970-31971 . denotes .
T14236 31959-31970 NN denotes alternative
T14235 31947-31958 JJ denotes interesting
T14234 31944-31946 DT denotes an
T14233 31941-31943 VB denotes be
T14232 31935-31940 MD denotes might
T14231 31931-31934 NNP denotes A20
T14230 31928-31930 IN denotes of
T14229 31917-31927 NNS denotes inhibitors
T14228 31908-31916 NN denotes compound
T14227 31902-31907 JJ denotes small
T14226 31897-31901 RB denotes Also
T14225 31895-31896 . denotes .
T14224 31887-31895 NN denotes approach
T14223 31875-31886 JJ denotes therapeutic
T14222 31869-31874 JJ denotes valid
T14221 31867-31868 DT denotes a
T14220 31864-31866 VB denotes be
T14219 31858-31863 MD denotes might
T14218 31854-31857 NNP denotes A20
T14217 31846-31853 IN denotes against
T14216 31840-31845 NN denotes siRNA
T14215 31837-31839 IN denotes of
T14214 31822-31836 NN denotes administration
T14213 31811-31821 JJ denotes intranasal
T14212 31808-31810 IN denotes by
T14211 31799-31807 NN denotes response
T14210 31792-31798 JJ denotes immune
T14209 31782-31791 JJ denotes antiviral
T14208 31778-31781 DT denotes the
T14207 31769-31777 VBG denotes boosting
T14206 31765-31768 CC denotes but
T14205 31763-31764 , denotes ,
T14204 31753-31763 NNS denotes components
T14203 31749-31752 NNP denotes IAV
T14202 31739-31748 VBG denotes targeting
T14201 31733-31738 JJ denotes siRNA
T14200 31728-31732 RB denotes only
T14199 31724-31727 RB denotes not
T14198 31719-31723 IN denotes that
T14197 31711-31718 VBP denotes suggest
T14196 31703-31710 NNS denotes results
T14195 31699-31702 PRP$ denotes Our
T14194 31697-31698 . denotes .
T14193 31696-31697 NNP denotes ]
T14192 31694-31696 CD denotes 83
T14191 31693-31694 NNP denotes [
T14190 31684-31692 NN denotes optimism
T14189 31680-31683 CC denotes and
T14188 31672-31679 NN denotes success
T14187 31660-31671 JJ denotes significant
T14186 31648-31659 VBN denotes experienced
T14185 31644-31647 VBZ denotes has
T14184 31642-31643 , denotes ,
T14183 31637-31642 NN denotes virus
T14182 31627-31636 VB denotes influenza
T14181 31624-31626 TO denotes to
T14180 31616-31623 VBN denotes limited
T14179 31612-31615 RB denotes not
T14178 31608-31611 CC denotes but
T14177 31606-31607 , denotes ,
T14176 31597-31606 VBG denotes including
T14175 31589-31596 NNS denotes viruses
T14174 31577-31588 JJ denotes respiratory
T14173 31569-31576 IN denotes against
T14172 31563-31568 NN denotes siRNA
T14171 31560-31562 IN denotes of
T14170 31548-31559 NN denotes application
T14169 31537-31547 JJ denotes intranasal
T14168 31535-31536 , denotes ,
T14167 31528-31535 JJ denotes general
T14166 31525-31527 IN denotes in
T14165 31520-31524 NNS denotes RNAi
T14164 31517-31519 IN denotes of
T14163 31504-31516 NNS denotes applications
T14162 31495-31503 JJ denotes clinical
T14161 31491-31494 DT denotes the
T14160 31488-31490 IN denotes in
T14159 31476-31487 NNS denotes bottlenecks
T14158 31470-31475 JJ denotes major
T14157 31463-31469 VBP denotes remain
T14156 31454-31462 NN denotes delivery
T14155 31447-31453 NN denotes tissue
T14154 31443-31446 CC denotes and
T14153 31431-31442 NN denotes specificity
T14152 31422-31430 IN denotes Although
T14151 31420-31421 . denotes .
T14150 31409-31420 NN denotes replication
T14149 31403-31408 NN denotes virus
T14148 31393-31402 NN denotes influenza
T14147 31390-31392 IN denotes of
T14146 31379-31389 NNS denotes inhibitors
T14145 31372-31378 JJ denotes potent
T14144 31369-31371 IN denotes as
T14143 31360-31368 VB denotes function
T14142 31357-31359 TO denotes to
T14141 31351-31356 VBN denotes shown
T14140 31346-31350 VBN denotes been
T14139 31341-31345 VBP denotes have
T14138 31334-31340 NNS denotes siRNAs
T14137 31325-31333 VBN denotes designed
T14136 31316-31324 RB denotes Properly
T14135 31314-31315 . denotes .
T14134 31307-31314 NN denotes regimen
T14133 31297-31306 JJ denotes antiviral
T14132 31290-31296 JJ denotes potent
T14131 31288-31289 DT denotes a
T14130 31285-31287 IN denotes as
T14129 31277-31284 VBN denotes evolved
T14128 31269-31276 RB denotes rapidly
T14127 31265-31268 VBZ denotes has
T14126 31263-31264 , denotes ,
T14125 31262-31263 -RRB- denotes )
T14124 31257-31262 NNP denotes siRNA
T14123 31256-31257 -LRB- denotes (
T14122 31252-31255 NNP denotes RNA
T14121 31240-31251 VBG denotes interfering
T14120 31234-31239 JJ denotes short
T14119 31224-31233 JJ denotes synthetic
T14118 31221-31223 IN denotes by
T14117 31211-31220 VBN denotes triggered
T14116 31209-31210 , denotes ,
T14115 31197-31209 NN denotes interference
T14114 31193-31196 NNP denotes RNA
T14113 31191-31192 , denotes ,
T14112 31186-31191 NNS denotes years
T14111 31179-31185 JJ denotes recent
T14110 31176-31178 IN denotes In
T14109 31174-31175 . denotes .
T14108 31168-31174 NN denotes battle
T14107 31161-31167 VBG denotes ending
T14106 31155-31160 RB denotes never
T14105 31153-31154 DT denotes a
T14104 31148-31152 IN denotes into
T14103 31141-31147 NN denotes design
T14102 31131-31140 JJ denotes antiviral
T14101 31127-31130 CC denotes and
T14100 31119-31126 NN denotes vaccine
T14099 31116-31118 IN denotes of
T14098 31107-31115 NNS denotes attempts
T14097 31103-31106 DT denotes all
T14096 31097-31102 VBZ denotes turns
T14095 31093-31096 NNP denotes IAV
T14094 31090-31092 IN denotes of
T14093 31085-31089 NN denotes rate
T14092 31076-31084 NN denotes mutation
T14091 31071-31075 JJ denotes high
T14090 31067-31070 DT denotes The
T14089 31065-31066 . denotes .
T14088 31048-31065 JJ denotes immunocompromised
T14087 31044-31047 DT denotes the
T14086 31040-31043 CC denotes and
T14085 31032-31039 JJ denotes elderly
T14084 31028-31031 DT denotes the
T14083 31026-31027 , denotes ,
T14082 31019-31026 NNS denotes infants
T14081 31016-31018 IN denotes in
T14080 31003-31015 RB denotes particularly
T14079 31001-31002 , denotes ,
T14078 30992-31001 NN denotes mortality
T14077 30988-30991 CC denotes and
T14076 30978-30987 NN denotes morbidity
T14075 30973-30977 JJ denotes high
T14074 30970-30972 TO denotes to
T14073 30962-30969 VBG denotes leading
T14072 30960-30961 , denotes ,
T14071 30952-30960 RB denotes annually
T14070 30948-30951 NNP denotes IAV
T14069 30945-30947 IN denotes by
T14068 30936-30944 VBN denotes infected
T14067 30933-30935 VBZ denotes is
T14066 30922-30932 NN denotes population
T14065 30919-30921 POS denotes 's
T14064 30914-30919 NN denotes world
T14063 30911-30913 IN denotes of
T14062 30905-30910 NN denotes fifth
T14061 30903-30904 DT denotes a
T14060 30897-30902 IN denotes About
T14059 30895-30896 . denotes .
T14058 30886-30895 NNS denotes therapies
T14057 30880-30885 NN denotes novel
T14056 30873-30879 IN denotes toward
T14055 30868-30872 NN denotes step
T14054 30858-30867 JJ denotes important
T14053 30855-30857 DT denotes an
T14052 30852-30854 VBZ denotes is
T14051 30842-30851 NNS denotes responses
T14050 30835-30841 JJ denotes immune
T14049 30825-30834 JJ denotes antiviral
T14048 30818-30824 NN denotes innate
T14047 30815-30817 IN denotes of
T14046 30804-30814 NN denotes activation
T14045 30800-30803 DT denotes the
T14044 30788-30799 VBG denotes controlling
T14043 30784-30787 CC denotes and
T14042 30770-30783 NN denotes Understanding
T14041 30768-30769 . denotes .
T14040 30756-30768 VBN denotes investigated
T14039 30753-30755 VB denotes be
T14038 30750-30752 TO denotes to
T14037 30742-30749 VBZ denotes remains
T14036 30740-30741 , denotes ,
T14035 30735-30740 NNS denotes cells
T14034 30724-30734 JJ denotes epithelial
T14033 30719-30723 NN denotes lung
T14032 30716-30718 IN denotes as
T14031 30711-30715 JJ denotes such
T14030 30709-30710 , denotes ,
T13843 29683-29685 PRP denotes us
T13842 29672-29682 VBG denotes preventing
T13841 29670-29671 , denotes ,
T13840 29659-29670 NNS denotes macrophages
T13839 29651-29658 JJ denotes primary
T13838 29648-29650 IN denotes in
T13837 29643-29647 NNP denotes IKKε
T13836 29639-29642 CC denotes and
T13835 29634-29638 CD denotes TBK1
T13834 29631-29633 IN denotes of
T13833 29616-29630 NN denotes ubiquitination
T13832 29609-29615 VB denotes detect
T13831 29601-29608 RB denotes clearly
T13830 29598-29600 TO denotes to
T13829 29591-29597 JJ denotes unable
T13828 29586-29590 VBD denotes were
T13827 29583-29585 PRP denotes we
T13826 29579-29582 RB denotes far
T13825 29576-29578 RB denotes So
T13824 29574-29575 . denotes .
T13823 29567-29574 JJ denotes unclear
T13822 29561-29566 RB denotes still
T13821 29558-29560 VBZ denotes is
T13820 29547-29557 NN denotes activation
T13819 29541-29546 NNP denotes NF-κB
T13818 29533-29540 VBD denotes induced
T13817 29527-29532 NNP denotes RIG-I
T13816 29524-29526 IN denotes of
T13815 29513-29523 NN denotes regulation
T13814 29509-29512 DT denotes the
T13813 29506-29508 IN denotes in
T13812 29497-29505 VBN denotes involved
T13811 29493-29496 VBP denotes are
T13810 29482-29492 NNS denotes mechanisms
T13809 29474-29481 JJ denotes similar
T13808 29466-29473 IN denotes Whether
T13807 29464-29465 . denotes .
T13806 29463-29464 NNP denotes ]
T13805 29461-29463 CD denotes 82
T13804 29460-29461 NNP denotes [
T13803 29458-29459 , denotes ,
T13802 29457-29458 NNP denotes ]
T13801 29455-29457 CD denotes 81
T13800 29454-29455 NNP denotes [
T13799 29449-29453 CD denotes IRF3
T13798 29440-29448 NN denotes activity
T13797 29437-29439 TO denotes to
T13796 29429-29436 NN denotes ability
T13795 29423-29428 PRP$ denotes their
T13794 29419-29422 CC denotes and
T13793 29417-29418 , denotes ,
T13792 29413-29417 NNP denotes IKKε
T13791 29409-29412 CC denotes and
T13790 29404-29408 CD denotes TBK1
T13789 29401-29403 IN denotes of
T13788 29378-29400 NN denotes K63-polyubiquitination
T13787 29368-29377 VBG denotes affecting
T13786 29357-29367 RB denotes negatively
T13785 29349-29356 RB denotes thereby
T13784 29347-29348 , denotes ,
T13783 29340-29347 NN denotes complex
T13782 29324-29339 NN denotes TRAF3-TBK1-IKKε
T13781 29320-29323 DT denotes the
T13780 29312-29319 VB denotes disrupt
T13779 29309-29311 TO denotes to
T13778 29306-29308 TO denotes to
T13777 29300-29305 CD denotes ABIN1
T13776 29296-29299 CC denotes and
T13775 29288-29295 CD denotes TAX1BP1
T13774 29279-29287 NNS denotes proteins
T13773 29261-29278 JJ denotes ubiquitin-binding
T13772 29257-29260 DT denotes the
T13771 29252-29256 IN denotes with
T13770 29241-29251 NNS denotes cooperates
T13769 29237-29240 CD denotes A20
T13768 29232-29236 IN denotes that
T13767 29226-29231 VBN denotes shown
T13766 29217-29225 RB denotes recently
T13765 29213-29216 VBD denotes was
T13764 29210-29212 PRP denotes it
T13763 29208-29209 , denotes ,
T13762 29201-29208 NN denotes context
T13761 29196-29200 DT denotes this
T13760 29193-29195 IN denotes In
T13759 29191-29192 . denotes .
T13758 29190-29191 NNP denotes ]
T13757 29188-29190 CD denotes 80
T13756 29187-29188 NNP denotes [
T13755 29178-29186 NNS denotes proteins
T13754 29168-29177 VBG denotes signaling
T13753 29158-29167 JJ denotes different
T13752 29155-29157 IN denotes of
T13751 29148-29154 NN denotes status
T13750 29133-29147 NN denotes ubiquitination
T13749 29129-29132 DT denotes the
T13748 29118-29128 VBG denotes modulating
T13747 29115-29117 IN denotes by
T13746 29105-29114 NNS denotes functions
T13745 29094-29104 JJ denotes inhibitory
T13744 29089-29093 NNP denotes IRF3
T13743 29085-29088 CC denotes and
T13742 29079-29084 NNP denotes NF-κB
T13741 29075-29078 PRP$ denotes its
T13740 29069-29074 VB denotes exert
T13739 29066-29068 TO denotes to
T13738 29057-29065 VBN denotes believed
T13737 29054-29056 VBZ denotes is
T13736 29050-29053 CD denotes A20
T13735 29048-29049 . denotes .
T13734 29038-29048 NN denotes expression
T13733 29033-29037 NN denotes gene
T13732 29017-29032 JJ denotes proinflammatory
T13731 29014-29016 TO denotes to
T13730 29003-29013 VB denotes contribute
T13729 28999-29002 MD denotes may
T13728 28994-28998 WDT denotes that
T13727 28985-28993 NNS denotes pathways
T13726 28975-28984 VBG denotes signaling
T13725 28969-28974 JJ denotes other
T13724 28966-28968 IN denotes on
T13723 28962-28965 NNP denotes A20
T13722 28959-28961 IN denotes of
T13721 28952-28958 NN denotes effect
T13720 28941-28951 JJ denotes additional
T13719 28938-28940 DT denotes an
T13718 28930-28937 VB denotes exclude
T13717 28926-28929 RB denotes not
T13716 28921-28925 VBZ denotes does
T13715 28916-28920 DT denotes this
T13714 28914-28915 , denotes ,
T13713 28907-28914 RB denotes However
T13712 28905-28906 . denotes .
T13711 28900-28905 NNS denotes genes
T13710 28894-28899 DT denotes these
T13709 28882-28893 VBG denotes controlling
T13708 28873-28881 NNS denotes pathways
T13707 28867-28872 JJ denotes major
T13706 28863-28866 DT denotes the
T13705 28859-28862 VBP denotes are
T13704 28853-28858 WDT denotes which
T13703 28851-28852 , denotes ,
T13702 28841-28851 NN denotes activation
T13701 28836-28840 NNP denotes IRF3
T13700 28832-28835 CC denotes and
T13699 28826-28831 NNP denotes NF-κB
T13698 28815-28825 VBG denotes regulating
T13697 28804-28814 RB denotes negatively
T13696 28801-28803 IN denotes by
T13695 28799-28800 -RRB- denotes )
T13694 28795-28799 NNP denotes IFNβ
T13693 28791-28794 CC denotes and
T13692 28789-28790 , denotes ,
T13691 28784-28789 NNP denotes MIP-2
T13690 28782-28783 , denotes ,
T13689 28780-28782 NNP denotes KC
T13688 28778-28779 , denotes ,
T13687 28774-28778 NNP denotes IL-6
T13686 28772-28773 , denotes ,
T13685 28769-28772 NNP denotes TNF
T13684 28765-28768 IN denotes for
T13683 28754-28764 NN denotes manuscript
T13682 28750-28753 PRP$ denotes our
T13681 28747-28749 IN denotes in
T13680 28741-28746 VBN denotes shown
T13679 28738-28740 IN denotes as
T13678 28737-28738 -LRB- denotes (
T13677 28726-28736 NN denotes expression
T13676 28721-28725 NN denotes gene
T13675 28705-28720 JJ denotes proinflammatory
T13674 28693-28704 JJ denotes IAV-induced
T13673 28684-28692 NNS denotes inhibits
T13672 28680-28683 CD denotes A20
T13671 28675-28679 IN denotes that
T13670 28667-28674 VBP denotes propose
T13669 28664-28666 PRP denotes We
T13668 28662-28663 . denotes .
T13667 28653-28662 VBG denotes signaling
T13666 28647-28652 NNP denotes RIG-I
T13665 28638-28646 JJ denotes enhanced
T13664 28629-28637 VBZ denotes reflects
T13663 28619-28628 NN denotes infection
T13662 28614-28618 NN denotes lung
T13661 28610-28613 NNP denotes IAV
T13660 28607-28609 TO denotes to
T13659 28602-28606 NNS denotes mice
T13658 28591-28601 JJ denotes A20myel-KO
T13657 28588-28590 IN denotes of
T13656 28579-28587 NN denotes response
T13655 28572-28578 JJ denotes immune
T13654 28562-28571 VBN denotes increased
T13545 27950-27959 RB denotes generally
T14260 32106-32107 . denotes .
T14259 32095-32106 NN denotes coronavirus
T14258 32090-32094 NNP denotes SARS
T14257 32086-32089 CC denotes and
T14256 32082-32085 NNP denotes RSV
T14255 32072-32081 VBG denotes including
T14254 32061-32071 NNS denotes infections
T14253 32055-32060 JJ denotes viral
T14252 32049-32054 JJ denotes other
T14251 32041-32048 IN denotes against
T14250 32034-32040 NN denotes battle
T14249 32030-32033 DT denotes the
T14248 32027-32029 IN denotes in
T14247 32018-32026 NN denotes interest
T14246 32015-32017 IN denotes of
T13653 28558-28561 DT denotes the
T13652 28553-28557 IN denotes that
T13651 28542-28552 VBG denotes suggesting
T13650 28540-28541 , denotes ,
T13649 28539-28540 NNP denotes ]
T13648 28537-28539 CD denotes 13
T13647 28536-28537 NNP denotes [
T13646 28532-28535 NNP denotes IAV
T13645 28529-28531 TO denotes to
T13644 28520-28528 NN denotes response
T13643 28513-28519 JJ denotes immune
T13642 28506-28512 NN denotes innate
T13641 28502-28505 DT denotes the
T13640 28499-28501 IN denotes in
T13639 28494-28498 NN denotes role
T13638 28490-28493 JJ denotes key
T13637 28488-28489 DT denotes a
T13636 28483-28487 VB denotes play
T13635 28480-28482 TO denotes to
T13634 28474-28479 VBN denotes shown
T13633 28469-28473 VBN denotes been
T13632 28458-28468 RB denotes previously
T13631 28454-28457 VBZ denotes has
T13630 28448-28453 NNP denotes RIG-I
T13629 28446-28447 . denotes .
T13628 28443-28446 NNP denotes RNA
T13581 28149-28150 NNP denotes +
T13580 28144-28149 NNP denotes CD11b
T13579 28142-28143 NN denotes +
T13578 28138-28142 JJ denotes Ly6C
T13577 28137-28138 -LRB- denotes (
T13576 28128-28136 NN denotes monocyte
T13575 28115-28127 JJ denotes inflammatory
T13574 28106-28114 VBG denotes altering
T13573 28098-28105 IN denotes without
T13572 28096-28097 , denotes ,
T13571 28085-28096 NN denotes recruitment
T13570 28074-28084 NN denotes neutrophil
T13569 28071-28073 IN denotes on
T13568 28060-28070 NN denotes deficiency
T13567 28056-28059 NNP denotes A20
T13566 28053-28055 IN denotes of
T13565 28046-28052 NN denotes effect
T13564 28036-28045 JJ denotes selective
T13563 28032-28035 DT denotes the
T13562 28030-28031 , denotes ,
T13561 28023-28030 RB denotes However
T13560 28021-28022 . denotes .
T13559 28020-28021 NNP denotes ]
T13558 28018-28020 CD denotes 79
T13557 28017-28018 NNP denotes [
T13556 28015-28016 , denotes ,
T13555 28014-28015 NNP denotes ]
T13554 28012-28014 CD denotes 64
T13553 28011-28012 NNP denotes [
T13552 28001-28010 NN denotes lethality
T13551 27991-28000 VBN denotes increased
T13550 27986-27990 IN denotes with
T13549 27975-27985 VBN denotes associated
T13548 27972-27974 VB denotes be
T13547 27969-27971 TO denotes to
T13546 27960-27968 VBN denotes believed
T13544 27947-27949 VBZ denotes is
T13543 27941-27946 NNS denotes cells
T13542 27928-27940 JJ denotes inflammatory
T13541 27925-27927 IN denotes of
T13540 27918-27924 NN denotes influx
T13539 27908-27917 JJ denotes excessive
T13538 27905-27907 DT denotes an
T13537 27901-27904 CC denotes and
T13536 27892-27900 NN denotes response
T13535 27883-27891 NN denotes cytokine
T13534 27867-27882 JJ denotes proinflammatory
T13533 27857-27866 JJ denotes excessive
T13532 27854-27856 DT denotes an
T13531 27848-27853 IN denotes since
T13530 27837-27847 JJ denotes surprising
T13529 27830-27836 RB denotes rather
T13528 27827-27829 VBZ denotes is
T13527 27821-27826 WDT denotes which
T13526 27819-27820 , denotes ,
T13525 27810-27819 NN denotes infection
T13524 27806-27809 NNP denotes IAV
T13523 27799-27805 JJ denotes lethal
T13522 27797-27798 DT denotes a
T13521 27789-27796 IN denotes against
T13520 27779-27788 VBN denotes protected
T13519 27774-27778 VBD denotes were
T13518 27769-27773 NNS denotes mice
T13517 27758-27768 JJ denotes A20myel-KO
T13516 27756-27757 . denotes .
T13515 27755-27756 NNP denotes ]
T13514 27753-27755 CD denotes 78
T13513 27752-27753 NNP denotes [
T13512 27736-27751 NN denotes immunopathology
T13511 27724-27735 JJ denotes IAV-induced
T13510 27721-27723 TO denotes to
T13509 27708-27720 NNS denotes contributors
T13508 27702-27707 JJ denotes major
T13507 27691-27701 VBN denotes considered
T13506 27687-27690 VBP denotes are
T13505 27683-27686 CC denotes and
T13504 27681-27682 NNP denotes ]
T13503 27679-27681 CD denotes 77
T13502 27678-27679 NNP denotes [
T13501 27666-27677 NNS denotes macrophages
T13500 27650-27665 JJ denotes proinflammatory
T13499 27647-27649 CC denotes or
T13498 27641-27646 NNS denotes cells
T13497 27631-27640 JJ denotes dendritic
T13496 27618-27630 JJ denotes inflammatory
T13495 27613-27617 IN denotes into
T13494 27605-27612 VBP denotes develop
T13493 27595-27604 NNS denotes monocytes
T13492 27589-27594 DT denotes these
T13491 27579-27588 NN denotes infection
T13490 27575-27578 NNP denotes IAV
T13489 27568-27574 IN denotes During
T13488 27566-27567 . denotes .
T13487 27565-27566 NNP denotes ]
T13486 27563-27565 CD denotes 76
T13485 27562-27563 NNP denotes [
T13484 27560-27561 NNP denotes ]
T13483 27558-27560 CD denotes 74
T13482 27557-27558 NNP denotes [
T13481 27541-27556 NN denotes immunopathology
T13480 27538-27540 IN denotes of
T13479 27532-27537 NNS denotes signs
T13478 27524-27531 VBN denotes reduced
T13477 27516-27523 NN denotes display
T13476 27512-27515 CC denotes and
T13475 27502-27511 NN denotes infection
T13474 27498-27501 NNP denotes IAV
T13473 27490-27497 IN denotes against
T13472 27480-27489 VBN denotes protected
T13471 27476-27479 VBP denotes are
T13470 27474-27475 , denotes ,
T13469 27465-27474 NNS denotes monocytes
T13468 27453-27464 VBG denotes circulating
T13467 27450-27452 IN denotes of
T13466 27443-27449 NN denotes subset
T13465 27441-27442 DT denotes a
T13464 27438-27440 IN denotes on
T13463 27428-27437 VBN denotes expressed
T13462 27425-27427 VBZ denotes is
T13461 27419-27424 WDT denotes which
T13460 27417-27418 , denotes ,
T13459 27413-27417 NNP denotes CCR2
T13458 27404-27412 NN denotes receptor
T13457 27398-27403 NN denotes MCP-1
T13456 27394-27397 DT denotes the
T13455 27390-27393 IN denotes for
T13454 27380-27389 NN denotes deficient
T13453 27375-27379 NNP denotes Mice
T13452 27373-27374 . denotes .
T13451 27372-27373 NNP denotes ]
T13450 27370-27372 CD denotes 73
T13449 27369-27370 NNP denotes [
T13448 27359-27368 NN denotes infection
T13447 27355-27358 NNP denotes IAV
T13446 27348-27354 IN denotes during
T13445 27337-27347 NN denotes production
T13444 27331-27336 JJ denotes MCP-1
T13443 27328-27330 IN denotes of
T13442 27321-27327 NN denotes source
T13441 27313-27320 JJ denotes primary
T13440 27309-27312 DT denotes the
T13439 27305-27308 VBP denotes are
T13438 27299-27304 NNS denotes cells
T13437 27288-27298 JJ denotes epithelial
T13436 27281-27287 NN denotes airway
T13435 27276-27280 IN denotes that
T13434 27269-27275 NN denotes notion
T13433 27265-27268 DT denotes the
T13432 27260-27264 IN denotes with
T13431 27249-27259 JJ denotes consistent
T13430 27246-27248 VBZ denotes is
T13429 27240-27245 WDT denotes which
T13428 27238-27239 , denotes ,
T13427 27233-27238 NNS denotes cells
T13426 27225-27232 JJ denotes myeloid
T13425 27222-27224 IN denotes in
T13424 27218-27221 NNP denotes A20
T13423 27215-27217 IN denotes of
T13422 27207-27214 NN denotes absence
T13421 27203-27206 DT denotes the
T13420 27200-27202 IN denotes by
T13419 27191-27199 VBN denotes affected
T13418 27187-27190 RB denotes not
T13417 27182-27186 VBD denotes were
T13416 27175-27181 NNS denotes levels
T13415 27169-27174 NN denotes MCP-1
T13414 27167-27168 . denotes .
T13413 27166-27167 NNP denotes ]
T13412 27164-27166 CD denotes 72
T13411 27163-27164 NNP denotes [
T13410 27161-27162 , denotes ,
T13409 27160-27161 NNP denotes ]
T13408 27158-27160 CD denotes 71
T13407 27157-27158 NNP denotes [
T13406 27147-27156 NN denotes infection
T13405 27143-27146 NNP denotes IAV
T13404 27136-27142 IN denotes during
T13403 27130-27135 NNS denotes cells
T13402 27124-27129 DT denotes these
T13401 27121-27123 IN denotes of
T13400 27112-27120 NN denotes function
T13399 27101-27111 JJ denotes protective
T13398 27099-27100 DT denotes a
T13397 27090-27098 VBZ denotes supports
T13396 27081-27089 NN denotes evidence
T13395 27074-27080 JJ denotes recent
T13394 27072-27073 , denotes ,
T13393 27066-27072 NN denotes debate
T13392 27060-27065 IN denotes under
T14029 30706-30709 NNP denotes IAV
T14028 30703-30705 TO denotes to
T14027 30694-30702 NN denotes response
T14026 30690-30693 DT denotes the
T14025 30687-30689 IN denotes in
T14024 30676-30686 VBN denotes implicated
T14023 30672-30675 VBP denotes are
T14022 30667-30671 WDT denotes that
T14021 30661-30666 NNS denotes types
T14020 30656-30660 NN denotes cell
T14019 30650-30655 JJ denotes other
T14018 30647-30649 IN denotes in
T14017 30642-30646 NN denotes role
T14016 30628-30641 JJ denotes non-redundant
T14015 30620-30627 JJ denotes similar
T14014 30618-30619 DT denotes a
T14013 30614-30617 VBZ denotes has
T14012 30610-30613 NNP denotes A20
T14011 30607-30609 IN denotes If
T14010 30605-30606 . denotes .
T14009 30595-30605 NNS denotes conditions
T14008 30581-30594 JJ denotes physiological
T14007 30575-30580 IN denotes under
T14006 30564-30574 NN denotes deficiency
T14005 30560-30563 NNP denotes A20
T14004 30556-30559 IN denotes for
T14003 30545-30555 VB denotes substitute
T14002 30541-30544 RB denotes not
T14001 30538-30541 MD denotes can
T14000 30533-30537 NNS denotes DUBs
T13999 30527-30532 JJ denotes other
T13998 30522-30526 IN denotes that
T13997 30518-30521 CC denotes and
T13996 30508-30517 NN denotes infection
T13995 30504-30507 NNP denotes IAV
T13994 30501-30503 TO denotes to
T13993 30492-30500 NN denotes response
T13992 30489-30491 IN denotes in
T13991 30479-30488 VBG denotes signaling
T13990 30471-30478 VBD denotes induced
T13989 30465-30470 NNP denotes RIG-I
T13988 30462-30464 IN denotes of
T13987 30451-30461 NN denotes gatekeeper
T13986 30443-30450 JJ denotes central
T13985 30441-30442 DT denotes a
T13984 30438-30440 VBZ denotes is
T13983 30432-30437 NNS denotes cells
T13982 30424-30431 JJ denotes myeloid
T13981 30421-30423 IN denotes in
T13980 30410-30420 NN denotes expression
T13979 30406-30409 NNP denotes A20
T13978 30401-30405 IN denotes that
T13977 30391-30400 VBZ denotes indicates
T13976 30382-30390 VBP denotes describe
T13975 30377-30381 RB denotes here
T13974 30374-30376 PRP denotes we
T13973 30369-30373 IN denotes that
T13972 30364-30368 NNS denotes mice
T13971 30353-30363 JJ denotes A20myel-KO
T13970 30350-30352 IN denotes of
T13969 30340-30349 NN denotes phenotype
T13968 30329-30339 JJ denotes protective
T13967 30323-30328 JJ denotes clear
T13966 30319-30322 DT denotes The
T13965 30317-30318 . denotes .
T13964 30307-30317 NNS denotes conditions
T13963 30289-30306 JJ denotes non-physiological
T13962 30283-30288 IN denotes under
T13961 30274-30282 VBN denotes obtained
T13960 30270-30273 VBD denotes was
T13959 30266-30269 CC denotes and
T13958 30261-30265 NNS denotes data
T13957 30255-30260 NN denotes vitro
T13956 30252-30254 IN denotes in
T13955 30249-30251 TO denotes to
T13954 30241-30248 VBN denotes limited
T13953 30237-30240 VBD denotes was
T13952 30233-30236 RB denotes far
T13951 30230-30232 RB denotes so
T13950 30221-30229 NN denotes evidence
T13949 30219-30220 , denotes ,
T13948 30212-30219 RB denotes However
T13947 30210-30211 . denotes .
T13946 30200-30210 NN denotes redundancy
T13945 30191-30199 JJ denotes possible
T13944 30179-30190 VBG denotes implicating
T13943 30177-30178 , denotes ,
T13942 30172-30177 NNP denotes IRF-3
T13941 30168-30171 CC denotes and
T13940 30162-30167 NNP denotes NF-κB
T13939 30159-30161 TO denotes to
T13938 30149-30158 VBG denotes signaling
T13937 30143-30148 NNP denotes RIG-I
T13936 30134-30142 VB denotes regulate
T13935 30123-30133 RB denotes negatively
T13934 30120-30122 TO denotes to
T13933 30114-30119 VBN denotes shown
T13932 30109-30113 VBN denotes been
T13931 30104-30108 VBP denotes have
T13930 30102-30103 NNP denotes ]
T13929 30100-30102 CD denotes 52
T13928 30099-30100 NNP denotes [
T13927 30097-30098 NNP denotes ]
T13926 30095-30097 CD denotes 49
T13925 30094-30095 NNP denotes [
T13924 30090-30093 NNP denotes A20
T13923 30086-30089 CC denotes and
T13922 30084-30085 , denotes ,
T13921 30083-30084 NNP denotes ]
T13920 30081-30083 CD denotes 31
T13919 30080-30081 NNP denotes [
T13918 30072-30079 NNP denotes OTUB1/2
T13917 30070-30071 , denotes ,
T13916 30069-30070 NNP denotes ]
T13915 30067-30069 CD denotes 30
T13914 30066-30067 NNP denotes [
T13913 30064-30065 , denotes ,
T13912 30063-30064 NNP denotes ]
T13911 30061-30063 CD denotes 29
T13910 30060-30061 NNP denotes [
T13909 30055-30059 NNP denotes CYLD
T13908 30053-30054 , denotes ,
T13907 30052-30053 NNP denotes ]
T13906 30050-30052 CD denotes 28
T13905 30049-30050 NNP denotes [
T13904 30044-30048 NNP denotes DUBA
T13903 30041-30043 IN denotes as
T13902 30036-30040 JJ denotes such
T13901 30034-30035 , denotes ,
T13900 30033-30034 -RRB- denotes )
T13899 30029-30033 NNS denotes DUBs
T13898 30028-30029 -LRB- denotes (
T13897 30020-30027 NNS denotes enzymes
T13896 30003-30019 VBG denotes deubiquitinating
T13895 29997-30002 JJ denotes other
T13894 29988-29996 JJ denotes Multiple
T13893 29986-29987 . denotes .
T13892 29976-29986 NN denotes laboratory
T13891 29972-29975 PRP$ denotes our
T13890 29969-29971 IN denotes in
T13889 29954-29968 NNS denotes investigations
T13888 29947-29953 JJ denotes future
T13887 29944-29946 IN denotes of
T13886 29938-29943 NN denotes topic
T13885 29934-29937 DT denotes the
T13884 29931-29933 VB denotes be
T13883 29926-29930 MD denotes will
T13882 29915-29925 NNS denotes substrates
T13881 29909-29914 DT denotes these
T13880 29906-29908 IN denotes of
T13879 29891-29905 NN denotes identification
T13878 29887-29890 DT denotes The
T13877 29885-29886 . denotes .
T13876 29880-29885 NNS denotes cells
T13875 29872-29879 JJ denotes myeloid
T13874 29869-29871 IN denotes in
T13873 29858-29868 NN denotes activation
T13872 29853-29857 NNP denotes IRF3
T13871 29849-29852 CC denotes and
T13870 29843-29848 NNP denotes NF-κB
T13869 29835-29842 VBP denotes mediate
T13868 29830-29834 WDT denotes that
T13867 29819-29829 NNS denotes substrates
T13866 29813-29818 JJ denotes other
T13865 29805-29812 VBZ denotes targets
T13864 29800-29804 RB denotes also
T13863 29796-29799 NNP denotes A20
T13862 29791-29795 IN denotes that
T13861 29783-29790 RB denotes however
T13860 29774-29782 VBN denotes excluded
T13859 29771-29773 VB denotes be
T13858 29767-29770 RB denotes not
T13857 29764-29767 MD denotes can
T13856 29761-29763 PRP denotes It
T13855 29759-29760 . denotes .
T13854 29753-29759 NN denotes status
T13853 29738-29752 NN denotes ubiquitination
T13852 29732-29737 PRP$ denotes their
T13851 29729-29731 IN denotes on
T13850 29718-29728 NN denotes deficiency
T13849 29714-29717 NNP denotes A20
T13848 29711-29713 IN denotes of
T13847 29704-29710 NN denotes effect
T13846 29700-29703 DT denotes the
T13845 29691-29699 VBG denotes studying
T13844 29686-29690 IN denotes from
T13391 27054-27059 RB denotes still
T13390 27051-27053 VBZ denotes is
T13389 27041-27050 NN denotes infection
T13388 27035-27040 JJ denotes viral
T13387 27028-27034 IN denotes during
T13386 27016-27027 NNS denotes neutrophils
T13385 27013-27015 IN denotes of
T13384 27008-27012 NN denotes role
T13383 27004-27007 DT denotes the
T13382 26995-27003 IN denotes Although
T13381 26993-26994 . denotes .
T13380 26984-26993 NN denotes infection
T13379 26977-26983 IN denotes during
T13378 26974-26976 IN denotes on
T13377 26968-26973 RB denotes later
T13376 26958-26967 NN denotes clearance
T13375 26952-26957 JJ denotes viral
T13374 26943-26951 VBN denotes improved
T13373 26940-26942 IN denotes in
T13372 26931-26939 VBD denotes resulted
T13371 26927-26930 CC denotes and
T13370 26925-26926 , denotes ,
T13369 26914-26925 NN denotes compartment
T13368 26898-26913 NN denotes bronchoalveolar
T13367 26894-26897 DT denotes the
T13366 26891-26893 TO denotes to
T13361 26843-26852 JJ denotes selective
T13360 26841-26842 DT denotes a
T13359 26836-26840 IN denotes with
T13358 26825-26835 VBN denotes associated
T13357 26821-26824 VBD denotes was
T13356 26816-26820 DT denotes This
T13355 26814-26815 . denotes .
T13354 26810-26814 NNS denotes mice
T13353 26805-26809 NN denotes type
T13352 26800-26804 JJ denotes wild
T13351 26797-26799 TO denotes to
T13350 26788-26796 VBN denotes compared
T13349 26783-26787 NNS denotes mice
T13348 26772-26782 JJ denotes A20myel-KO
T13347 26769-26771 IN denotes of
T13346 26763-26768 NNS denotes lungs
T13345 26759-26762 DT denotes the
T13344 26756-26758 IN denotes in
T13343 26750-26755 NNP denotes IL-1β
T13342 26746-26749 CC denotes and
T13341 26742-26745 NNP denotes TNF
T13340 26740-26741 , denotes ,
T13339 26736-26740 NNP denotes IL-6
T13338 26733-26735 IN denotes as
T13337 26728-26732 JJ denotes such
T13336 26718-26727 NNS denotes cytokines
T13335 26702-26717 JJ denotes proinflammatory
T13334 26694-26701 JJ denotes several
T13333 26690-26693 CC denotes and
T13332 26684-26689 NNP denotes MIP-2
T13331 26680-26683 CC denotes and
T13330 26677-26679 NNP denotes KC
T13329 26674-26676 IN denotes as
T13328 26669-26673 JJ denotes such
T13327 26658-26668 NNS denotes chemokines
T13326 26647-26657 VBG denotes attracting
T13325 26636-26646 NN denotes neutrophil
T13324 26626-26635 RB denotes primarily
T13323 26623-26625 IN denotes of
T13322 26616-26622 NNS denotes levels
T13321 26609-26615 JJR denotes higher
T13320 26606-26608 IN denotes in
T13319 26597-26605 VBD denotes resulted
T13318 26593-26596 NNP denotes IAV
T13317 26588-26592 IN denotes with
T13316 26578-26587 NN denotes infection
T13315 26573-26577 NN denotes vivo
T13314 26570-26572 IN denotes in
T13313 26568-26569 , denotes ,
T13312 26559-26568 RB denotes Similarly
T13311 26557-26558 . denotes .
T13310 26548-26557 NN denotes infection
T13309 26542-26547 NN denotes vitro
T13308 26539-26541 IN denotes in
T13307 26536-26538 TO denotes to
T13306 26527-26535 NN denotes response
T13305 26524-26526 IN denotes in
T13304 26519-26523 NNS denotes mice
T13303 26514-26518 NN denotes type
T13302 26509-26513 JJ denotes wild
T13301 26506-26508 TO denotes to
T13300 26497-26505 VBN denotes compared
T13299 26492-26496 VBP denotes IFNs
T13298 26490-26491 PRP denotes I
T13297 26485-26489 NN denotes type
T13296 26481-26484 CC denotes and
T13295 26471-26480 NNS denotes cytokines
T13294 26469-26470 , denotes ,
T13293 26459-26469 NNS denotes chemokines
T13292 26456-26458 IN denotes of
T13291 26448-26455 NNS denotes amounts
T13290 26441-26447 JJR denotes higher
T13289 26433-26440 VBP denotes express
T13288 26428-26432 NNS denotes mice
T13287 26417-26427 JJ denotes A20myel-KO
T13286 26412-26416 IN denotes from
T13285 26404-26411 VBN denotes derived
T13284 26392-26403 NNS denotes macrophages
T13283 26383-26391 JJ denotes alveolar
T13282 26380-26382 CC denotes or
T13281 26375-26379 NNP denotes BMDM
T13280 26370-26374 IN denotes that
T13279 26365-26369 VB denotes show
T13278 26359-26364 MD denotes could
T13277 26356-26358 PRP denotes We
T13276 26354-26355 . denotes .
T13275 26345-26354 NN denotes clearance
T13274 26339-26344 JJ denotes viral
T13272 26323-26335 VBG denotes contributing
T13271 26315-26322 JJ denotes further
T13270 26313-26314 , denotes ,
T13269 26304-26313 NNS denotes particles
T13268 26298-26303 JJ denotes viral
T13267 26291-26297 JJ denotes coated
T13266 26282-26290 NN denotes antibody
T13265 26278-26281 CC denotes and
T13264 26272-26277 NNS denotes cells
T13263 26262-26271 JJ denotes apoptotic
T13262 26253-26261 JJ denotes infected
T13261 26247-26252 NN denotes virus
T13260 26235-26246 VB denotes phagocytose
T13259 26232-26234 TO denotes to
T13258 26226-26231 VBN denotes known
T13257 26221-26225 RB denotes also
T13256 26217-26220 VBP denotes are
T13255 26205-26216 NNS denotes macrophages
T13254 26196-26204 NNP denotes Alveolar
T13253 26194-26195 . denotes .
T13252 26193-26194 NNP denotes ]
T13251 26191-26193 CD denotes 70
T13250 26190-26191 NNP denotes [
T13249 26185-26189 NNPS denotes IFNs
T13248 26183-26184 PRP denotes I
T13247 26178-26182 NN denotes type
T13246 26175-26177 IN denotes of
T13245 26165-26174 NNS denotes producers
T13244 26157-26164 JJ denotes primary
T13243 26153-26156 DT denotes the
T13242 26149-26152 VBP denotes are
T13241 26144-26148 PRP denotes they
T13240 26140-26143 CC denotes and
T13239 26138-26139 , denotes ,
T13238 26137-26138 NNP denotes ]
T13237 26135-26137 CD denotes 69
T13236 26134-26135 NNP denotes [
T13235 26124-26133 NN denotes infection
T13234 26121-26123 IN denotes of
T13233 26115-26120 NN denotes phase
T13232 26107-26114 JJ denotes primary
T13231 26103-26106 DT denotes the
T13203 25956-25965 NNS denotes particles
T13202 25952-25955 NNP denotes IAV
T13201 25941-25951 JJ denotes infectious
T13200 25931-25940 VBP denotes encounter
T13199 25926-25930 WDT denotes that
T13198 25920-25925 NNS denotes cells
T13197 25914-25919 JJ denotes first
T13196 25910-25913 DT denotes the
T13195 25907-25909 IN denotes of
T13194 25903-25906 CD denotes one
T13193 25899-25902 VBP denotes are
T13192 25894-25898 PRP denotes they
T13191 25891-25893 IN denotes as
T13190 25887-25890 NNP denotes IAV
T13189 25879-25886 IN denotes against
T13188 25870-25878 NN denotes response
T13187 25863-25869 JJ denotes immune
T13186 25856-25862 NN denotes innate
T13185 25852-25855 DT denotes the
T13184 25849-25851 IN denotes in
T13183 25841-25848 JJ denotes crucial
T13182 25836-25840 RB denotes also
T13181 25832-25835 VBP denotes are
T13180 25820-25831 NNS denotes macrophages
T13179 25811-25819 JJ denotes alveolar
T13178 25809-25810 , denotes ,
T13177 25802-25809 RB denotes However
T13176 25800-25801 . denotes .
T13175 25799-25800 NNP denotes ]
T13174 25797-25799 CD denotes 66
T13173 25796-25797 NNP denotes [
T13172 25794-25795 , denotes ,
T13627 28434-28442 VBD denotes stranded
T13626 28427-28433 JJ denotes double
T13625 28423-28426 NNP denotes LMW
T13624 28413-28422 JJ denotes synthetic
T13623 28410-28412 IN denotes by
T13622 28398-28409 NN denotes stimulation
T13621 28392-28397 NNP denotes RIG-I
T13620 28389-28391 TO denotes to
T13619 28380-28388 NN denotes response
T13618 28377-28379 IN denotes in
T13617 28366-28376 NN denotes activation
T13616 28361-28365 NNP denotes IRF3
T13615 28357-28360 CC denotes and
T13614 28351-28356 NNP denotes NF-κB
T13613 28342-28350 VBN denotes enhanced
T13612 28334-28341 NN denotes display
T13611 28329-28333 NNP denotes BMDM
T13610 28319-28328 JJ denotes deficient
T13609 28315-28318 CD denotes A20
T13608 28310-28314 IN denotes that
T13607 28305-28309 VBP denotes show
T13606 28302-28304 PRP denotes We
T13605 28300-28301 . denotes .
T13604 28299-28300 NNP denotes ]
T13603 28297-28299 CD denotes 78
T13602 28296-28297 NNP denotes [
T13601 28286-28295 NN denotes lethality
T13600 28282-28285 CC denotes and
T13599 28266-28281 NN denotes immunopathology
T13598 28251-28265 JJ denotes IAV-associated
T13597 28248-28250 TO denotes to
T13596 28235-28247 NNS denotes contributors
T13595 28229-28234 JJ denotes major
T13594 28225-28228 VBP denotes are
T13593 28213-28224 NNS denotes neutrophils
T13592 28209-28212 RB denotes not
T13591 28205-28208 CC denotes and
T13590 28195-28204 VBZ denotes monocytes
T13589 28190-28194 WDT denotes that
T13588 28185-28189 NN denotes idea
T13587 28181-28184 DT denotes the
T13586 28173-28180 NN denotes support
T13585 28165-28172 JJ denotes further
T13584 28163-28164 , denotes ,
T13583 28152-28163 NN denotes recruitment
T13582 28150-28151 -RRB- denotes )
T13171 25793-25794 NNP denotes ]
T13170 25791-25793 CD denotes 65
T13169 25790-25791 NNP denotes [
T13168 25780-25789 NNS denotes functions
T13167 25763-25779 JJ denotes immunomodulatory
T13166 25753-25762 JJ denotes important
T13165 25747-25752 VBP denotes exert
T13164 25735-25746 NNS denotes macrophages
T13163 25726-25734 JJ denotes alveolar
T13162 25724-25725 , denotes ,
T13161 25714-25724 NNS denotes conditions
T13160 25708-25713 NN denotes naïve
T13159 25702-25707 IN denotes Under
T13158 25700-25701 . denotes .
T13157 25689-25700 NNS denotes macrophages
T13156 25680-25688 JJ denotes alveolar
T13155 25677-25679 IN denotes as
T13154 25674-25676 TO denotes to
T13153 25665-25673 VBN denotes referred
T13152 25661-25664 VBP denotes are
T13151 25656-25660 PRP denotes they
T13150 25650-25655 WRB denotes where
T13149 25644-25649 NNS denotes lumen
T13148 25635-25643 JJ denotes alveolar
T13147 25631-25634 DT denotes the
T13146 25627-25630 CC denotes and
T13365 26879-26890 NN denotes recruitment
T13364 26868-26878 NN denotes neutrophil
T13363 26865-26867 IN denotes of
T13362 26853-26864 NN denotes enhancement
T13135 25553-25554 . denotes .
T13134 25544-25553 NN denotes infection
T13133 25539-25543 NN denotes lung
T13132 25535-25538 NNP denotes IAV
T13131 25532-25534 TO denotes to
T13130 25523-25531 NN denotes response
T13129 25516-25522 JJ denotes immune
T13128 25509-25515 NN denotes innate
T13127 25505-25508 DT denotes the
T13126 25502-25504 IN denotes in
T13125 25496-25501 NNS denotes cells
T13124 25488-25495 JJ denotes myeloid
T13123 25485-25487 IN denotes in
T13122 25474-25484 NN denotes expression
T13121 25470-25473 NNP denotes A20
T13120 25467-25469 IN denotes of
T13119 25454-25466 NN denotes contribution
T13118 25450-25453 DT denotes the
T13117 25437-25449 VBN denotes investigated
T13116 25432-25436 VBP denotes have
T13115 25429-25431 PRP denotes we
T13145 25616-25626 NN denotes parenchyma
T13144 25611-25615 NN denotes lung
T13143 25606-25610 DT denotes both
T13142 25597-25605 VBP denotes populate
T13141 25585-25596 NNS denotes macrophages
T13140 25583-25584 , denotes ,
T13139 25572-25583 NN denotes environment
T13138 25562-25571 JJ denotes pulmonary
T13137 25558-25561 DT denotes the
T13136 25555-25557 IN denotes In
T11115 24606-24607 . denotes .
T11114 24597-24606 NN denotes infection
T11113 24593-24596 NNP denotes IAV
T11112 24586-24592 JJ denotes lethal
T11111 24584-24585 DT denotes a
T11110 24576-24583 IN denotes against
T11109 24565-24575 NN denotes protection
T11108 24561-24564 CC denotes and
T11107 24552-24560 NN denotes response
T11106 24545-24551 JJ denotes immune
T11105 24538-24544 NN denotes innate
T11104 24528-24537 VBN denotes increased
T11103 24525-24527 DT denotes an
T11102 24520-24524 IN denotes with
T11101 24509-24519 VBN denotes associated
T11100 24506-24508 VBZ denotes is
T11099 24500-24505 NNS denotes cells
T11098 24492-24499 JJ denotes myeloid
T11097 24489-24491 IN denotes in
T11096 24478-24488 NN denotes deficiency
T11095 24474-24477 CD denotes A20
T11094 24469-24473 IN denotes that
T11093 24460-24468 VBP denotes indicate
T11092 24455-24459 NNS denotes data
T11091 24449-24454 DT denotes these
T11090 24436-24448 RB denotes Collectively
T11089 24434-24435 . denotes .
T11088 24433-24434 -RRB- denotes )
T11087 24432-24433 NN denotes F
T11086 24428-24431 CD denotes S3B
T11052 24230-24233 CC denotes and
T11051 24228-24229 , denotes ,
T11050 24227-24228 -RRB- denotes )
T11049 24225-24227 NN denotes 4C
T11048 24218-24224 NN denotes figure
T11047 24217-24218 -LRB- denotes (
T11046 24212-24216 NNS denotes mice
T11045 24201-24211 JJ denotes A20myel-KO
T11044 24198-24200 IN denotes in
T11041 24183-24186 CC denotes and
T11040 24173-24182 VBN denotes increased
T11039 24169-24172 RB denotes not
T11038 24165-24168 VBD denotes was
T11037 24154-24164 NN denotes production
T11036 24148-24153 JJ denotes MCP-1
T11035 24146-24147 , denotes ,
T11034 24141-24146 RB denotes Again
T11033 24139-24140 . denotes .
T11032 24138-24139 -RRB- denotes )
T11031 24135-24138 NNP denotes S3A
T11030 24128-24134 NN denotes figure
T11029 24124-24127 CC denotes and
T11028 24121-24123 NN denotes 4C
T11027 24114-24120 NN denotes figure
T11026 24113-24114 -LRB- denotes (
T11025 24105-24112 NNS denotes animals
T11024 24097-24104 VB denotes control
T11023 24094-24096 TO denotes to
T11022 24085-24093 VBN denotes compared
T11021 24080-24084 NNS denotes mice
T11020 24069-24079 JJ denotes A20myel-KO
T11019 24066-24068 IN denotes of
T11018 24060-24065 NNS denotes lungs
T11017 24056-24059 DT denotes the
T11016 24053-24055 IN denotes in
T11015 24043-24052 VBN denotes increased
T11014 24038-24042 VBD denotes were
T11013 24036-24037 , denotes ,
T11012 24035-24036 NNP denotes ]
T11011 24033-24035 CD denotes 64
T11010 24032-24033 NNP denotes [
T11009 24025-24031 NNS denotes humans
T11008 24022-24024 IN denotes in
T11007 24003-24021 NN denotes immunopathogenesis
T11006 23998-24002 IN denotes with
T11005 23987-23997 VBN denotes associated
T11004 23981-23986 RB denotes often
T11003 23977-23980 VBP denotes are
T11002 23971-23976 WDT denotes which
T10985 23892-23893 -LRB- denotes (
T10984 23887-23891 NNS denotes mice
T10983 23881-23886 DT denotes these
T10982 23878-23880 IN denotes of
T10981 23872-23877 NNS denotes lungs
T10980 23868-23871 DT denotes the
T10979 23865-23867 IN denotes in
T10978 23853-23864 NNS denotes neutrophils
T10977 23850-23852 IN denotes of
T10976 23842-23849 NNS denotes numbers
T10975 23832-23841 VBN denotes increased
T10974 23828-23831 DT denotes the
T10973 23823-23827 IN denotes with
T10972 23812-23822 VBZ denotes correlates
T10971 23806-23811 WDT denotes which
T10970 23804-23805 , denotes ,
T10969 23803-23804 -RRB- denotes )
T10968 23801-23803 NN denotes 4C
T10967 23794-23800 NN denotes figure
T10966 23793-23794 -LRB- denotes (
T10965 23783-23792 NN denotes infection
T10964 23779-23782 NNP denotes IAV
T10963 23772-23778 JJ denotes lethal
T10962 23762-23771 VBG denotes following
T10961 23757-23761 NNS denotes mice
T10960 23752-23756 NN denotes type
T10959 23747-23751 JJ denotes wild
T10958 23744-23746 TO denotes to
T10957 23735-23743 VBN denotes compared
T10956 23727-23734 NNS denotes animals
T10955 23716-23726 JJ denotes A20myel-KO
T10954 23713-23715 IN denotes in
T10953 23704-23712 JJR denotes stronger
T10952 23700-23703 VBD denotes was
T10951 23689-23699 NN denotes production
T10947 23666-23675 JJ denotes pulmonary
T10946 23664-23665 , denotes ,
T10945 23655-23664 NN denotes infection
T10944 23651-23654 NNP denotes IAV
T10943 23641-23650 JJ denotes sublethal
T10942 23636-23640 IN denotes with
T10941 23623-23635 NNS denotes observations
T10940 23619-23622 PRP$ denotes our
T10939 23616-23618 TO denotes to
T10938 23608-23615 JJ denotes Similar
T10937 23606-23607 . denotes .
T10936 23605-23606 -RRB- denotes )
T10935 23603-23605 NN denotes 4B
T10934 23596-23602 NN denotes figure
T10933 23595-23596 -LRB- denotes (
T10932 23585-23594 VBD denotes succumbed
T10931 23580-23584 WDT denotes that
T10930 23575-23579 NNS denotes mice
T10929 23570-23574 NN denotes type
T10928 23565-23569 JJ denotes wild
T10927 23562-23564 TO denotes to
T10926 23553-23561 NN denotes contrast
T10925 23550-23552 IN denotes in
T10924 23548-23549 , denotes ,
T10923 23541-23548 VB denotes recover
T10922 23538-23540 TO denotes to
T10921 23533-23537 JJ denotes able
T10920 23528-23532 VBD denotes were
T10919 23524-23527 CC denotes but
T10918 23514-23523 NN denotes infection
T10917 23511-23513 IN denotes of
T10916 23504-23510 NN denotes course
T10915 23500-23503 DT denotes the
T10914 23493-23499 IN denotes during
T10913 23491-23492 -RRB- denotes )
T10912 23486-23491 VBN denotes shown
T10911 23482-23485 RB denotes not
T10910 23477-23481 NNS denotes data
T10909 23475-23476 : denotes ;
T10908 23472-23475 NNP denotes BAL
T10907 23468-23471 DT denotes the
T10906 23465-23467 IN denotes in
T10905 23451-23464 NN denotes concentration
T10904 23443-23450 NN denotes protein
T10903 23437-23442 JJ denotes total
T10902 23427-23436 VBN denotes increased
T10901 23424-23426 IN denotes by
T10900 23414-23423 VBN denotes reflected
T10899 23411-23413 IN denotes as
T10898 23410-23411 -LRB- denotes (
T10897 23403-23409 NN denotes damage
T10896 23398-23402 NN denotes lung
T10895 23394-23397 CC denotes and
T10894 23389-23393 NN denotes loss
T10893 23382-23388 NN denotes weight
T10892 23370-23381 JJ denotes significant
T10891 23363-23369 VBD denotes showed
T10890 23357-23362 RB denotes still
T10889 23352-23356 NNS denotes mice
T10888 23341-23351 JJ denotes A20myel-KO
T10887 23339-23340 . denotes .
T10886 23338-23339 -RRB- denotes )
T10885 23336-23338 NN denotes 4A
T10884 23329-23335 NN denotes figure
T10883 23328-23329 -LRB- denotes (
T10882 23318-23327 NN denotes infection
T10881 23312-23317 IN denotes after
T10880 23307-23311 NNS denotes days
T10879 23304-23306 CD denotes 16
T10878 23297-23303 IN denotes within
T10877 23295-23296 -RRB- denotes )
T10876 23291-23295 CD denotes 0/11
T10875 23290-23291 -LRB- denotes (
T10874 23280-23289 VBN denotes succumbed
T10873 23275-23279 NNS denotes mice
T10872 23267-23274 NN denotes control
T10871 23263-23266 DT denotes all
T10870 23257-23262 IN denotes while
T10869 23255-23256 , denotes ,
T10868 23254-23255 -RRB- denotes )
T10867 23249-23254 CD denotes 10/11
T10866 23248-23249 -LRB- denotes (
T10865 23239-23247 VBD denotes survived
T10864 23234-23238 NNS denotes mice
T10863 23223-23233 JJ denotes A20myel-KO
T10862 23219-23222 DT denotes all
T10861 23212-23218 RB denotes almost
T10860 23210-23211 , denotes ,
T10859 23198-23210 RB denotes Surprisingly
T10858 23196-23197 . denotes .
T10857 23192-23196 NNP denotes X-47
T10856 23188-23191 NNP denotes IAV
T10855 23185-23187 IN denotes of
T10854 23180-23184 NN denotes dose
T10853 23173-23179 JJ denotes lethal
T10852 23171-23172 DT denotes a
T10851 23166-23170 IN denotes with
T10850 23156-23165 NN denotes infection
T10849 23145-23155 JJ denotes intranasal
T10848 23142-23144 IN denotes by
T10847 23134-23141 VBN denotes induced
T10846 23124-23133 NN denotes mortality
T10845 23116-23123 VBZ denotes affects
T10844 23111-23115 NNS denotes mice
T10843 23100-23110 JJ denotes A20myel-KO
T10842 23097-23099 IN denotes in
T10841 23091-23096 NNS denotes cells
T10840 23075-23090 JJ denotes proinflammatory
T10839 23072-23074 IN denotes of
T10838 23059-23071 NN denotes infiltration
T10837 23055-23058 CC denotes and
T10836 23044-23054 NN denotes production
T10835 23035-23043 NN denotes cytokine
T10834 23019-23034 JJ denotes proinflammatory
T10833 23009-23018 VBN denotes increased
T10832 23005-23008 DT denotes the
T10831 22997-23004 IN denotes whether
T10830 22988-22996 VBD denotes analyzed
T10829 22978-22987 RB denotes therefore
T10828 22975-22977 PRP denotes We
T10827 22973-22974 . denotes .
T10826 22969-22973 NN denotes lung
T10825 22965-22968 DT denotes the
T10824 22962-22964 IN denotes in
T10823 22953-22961 NN denotes response
T10822 22937-22952 JJ denotes proinflammatory
T10821 22927-22936 JJ denotes excessive
T10820 22924-22926 DT denotes an
T10819 22921-22923 TO denotes to
T10818 22917-22920 JJ denotes due
T10817 22914-22916 VBZ denotes is
T10816 22904-22913 NN denotes mortality
T10815 22892-22903 JJ denotes IAV-induced
T10814 22887-22891 IN denotes that
T10813 22878-22886 VBN denotes believed
T10812 22868-22877 RB denotes generally
T10811 22865-22867 VBZ denotes is
T10810 22862-22864 PRP denotes It
T10809 22860-22861 . denotes .
T10808 22856-22860 NNS denotes mice
T10807 22845-22855 JJ denotes A20myel-KO
T10806 22842-22844 IN denotes in
T10805 22832-22841 NN denotes clearance
T10804 22826-22831 JJ denotes viral
T10803 22819-22825 JJR denotes better
T10802 22815-22818 DT denotes the
T10801 22812-22814 TO denotes to
T10800 22801-22811 VBP denotes contribute
T10799 22799-22800 , denotes ,
T10798 22788-22799 NNS denotes macrophages
T10797 22779-22787 JJ denotes alveolar
T10796 22776-22778 IN denotes of
T10795 22768-22775 NNS denotes numbers
T10794 22758-22767 VBD denotes increased
T10793 22754-22757 CC denotes and
T10792 22742-22753 NNS denotes neutrophils
T10791 22739-22741 IN denotes of
T10790 22732-22738 NN denotes influx
T10789 22722-22731 VBN denotes increased
T10788 22719-22721 DT denotes an
T10787 22716-22718 IN denotes by
T10786 22702-22715 VBN denotes characterized
T10785 22700-22701 , denotes ,
T10784 22692-22700 NN denotes response
T10783 22685-22691 JJ denotes immune
T10782 22678-22684 NN denotes innate
T10781 22668-22677 VBN denotes increased
T10780 22665-22667 DT denotes an
T10779 22662-22664 IN denotes as
T10778 22657-22661 JJ denotes such
T10777 22655-22656 , denotes ,
T10776 22647-22655 NN denotes immunity
T10775 22638-22646 JJ denotes adaptive
T10774 22633-22637 IN denotes than
T10773 22627-22632 JJ denotes other
T10772 22616-22626 NNS denotes mechanisms
T10771 22611-22615 IN denotes that
T10770 22603-22610 VBP denotes suggest
T10732 22387-22398 NNS denotes littermates
T10731 22382-22386 NN denotes type
T10730 22377-22381 JJ denotes wild
T10729 22373-22376 CC denotes and
T10728 22362-22372 JJ denotes A20myel-KO
T10727 22359-22361 IN denotes of
T10726 22353-22358 NN denotes serum
T10725 22349-22352 DT denotes the
T10724 22346-22348 IN denotes in
T10723 22339-22345 NNS denotes titers
T10722 22330-22338 NN denotes antibody
T10721 22328-22329 -RRB- denotes )
T10720 22326-22328 NNP denotes HA
T10719 22325-22326 -LRB- denotes (
T10718 22311-22324 NN denotes hemagglutinin
T10717 22300-22310 VBD denotes determined
T10716 22297-22299 PRP denotes we
T10715 22295-22296 , denotes ,
T10714 22287-22295 NN denotes immunity
T10713 22278-22286 VBD denotes mediated
T10712 22273-22277 NN denotes cell
T10711 22271-22272 NNP denotes B
T10710 22263-22270 VBZ denotes affects
T10709 22257-22262 NNS denotes cells
T10708 22249-22256 JJ denotes myeloid
T10707 22246-22248 IN denotes in
T10706 22242-22245 NNP denotes A20
T10705 22239-22241 IN denotes of
T10704 22234-22238 NN denotes loss
T10703 22226-22233 IN denotes whether
T10702 22221-22225 VB denotes test
T10701 22218-22220 TO denotes To
T10700 22216-22217 . denotes .
T10699 22208-22216 NN denotes response
T10698 22201-22207 JJ denotes immune
T10697 22193-22200 JJ denotes humoral
T10696 22189-22192 DT denotes the
T10695 22186-22188 IN denotes by
T10694 22177-22185 VBN denotes provided
T10693 22172-22176 RB denotes also
T10692 22169-22171 VBZ denotes is
T10691 22159-22168 NN denotes infection
T10690 22155-22158 NNP denotes IAV
T10689 22147-22154 IN denotes against
T10688 22136-22146 NN denotes Protection
T10687 22134-22135 . denotes .
T10686 22133-22134 -RRB- denotes )
T10685 22132-22133 NNP denotes C
T10684 22128-22131 NNP denotes S2A
T10683 22121-22127 NN denotes figure
T10682 22120-22121 -LRB- denotes (
T10681 22114-22119 NNS denotes cells
T10680 22106-22113 JJ denotes myeloid
T10679 22103-22105 IN denotes in
T10678 22099-22102 NNP denotes A20
T10677 22096-22098 IN denotes of
T10676 22088-22095 NN denotes absence
T10675 22084-22087 DT denotes the
T10674 22081-22083 IN denotes by
T10673 22073-22080 VBN denotes altered
T10672 22069-22072 RB denotes not
T10671 22064-22068 VBD denotes were
T10670 22058-22063 NNS denotes lungs
T10669 22054-22057 DT denotes the
T10668 22051-22053 IN denotes in
T10667 22044-22050 NNS denotes levels
T10666 22033-22043 NN denotes expression
T10665 22028-22032 NNP denotes IFNγ
T10664 22025-22027 IN denotes as
T10663 22020-22024 RB denotes well
T10662 22017-22019 RB denotes as
T10661 22011-22016 NNS denotes cells
T10660 22009-22010 NNP denotes T
T10659 22007-22008 VBD denotes +
T10658 22004-22007 NNP denotes CD8
T10657 21999-22003 NNP denotes IFNγ
T10656 21995-21998 CC denotes and
T10655 21991-21994 NNP denotes GrB
T10654 21988-21990 IN denotes of
T10653 21981-21987 NN denotes number
T10652 21977-21980 DT denotes the
T10651 21975-21976 , denotes ,
T10650 21971-21975 RB denotes Also
T10649 21969-21970 . denotes .
T10648 21968-21969 -RRB- denotes )
T10647 21965-21968 NNP denotes S2C
T10646 21958-21964 NN denotes figure
T10645 21954-21957 CC denotes and
T10644 21950-21953 NNP denotes S2A
T10643 21943-21949 NN denotes figure
T10642 21942-21943 -LRB- denotes (
T10641 21937-21941 NNS denotes mice
T10640 21932-21936 NN denotes type
T10639 21927-21931 JJ denotes wild
T10638 21923-21926 CC denotes and
T10637 21912-21922 JJ denotes A20myel-KO
T10636 21904-21911 IN denotes between
T10635 21895-21903 VBN denotes observed
T10634 21890-21894 VBD denotes were
T10633 21878-21889 NNS denotes differences
T10632 21875-21877 DT denotes no
T10631 21871-21874 CC denotes but
T10630 21869-21870 , denotes ,
T10629 21860-21869 NN denotes infection
T10628 21855-21859 NN denotes post
T10627 21852-21854 CD denotes 10
T10626 21848-21851 CC denotes and
T10625 21846-21847 CD denotes 7
T10624 21842-21845 NN denotes day
T10623 21839-21841 IN denotes at
T10622 21830-21838 VBN denotes detected
T10621 21827-21829 VB denotes be
T10620 21821-21826 MD denotes could
T10619 21815-21820 NNS denotes cells
T10618 21813-21814 NNP denotes T
T10617 21811-21812 CD denotes +
T10616 21808-21811 CD denotes CD8
T10615 21805-21807 IN denotes in
T10614 21796-21804 NN denotes increase
T10613 21790-21795 JJ denotes clear
T10612 21788-21789 DT denotes A
T10611 21786-21787 . denotes .
T10610 21782-21786 NNS denotes mice
T10609 21771-21781 JJ denotes A20myel-KO
T10608 21767-21770 CC denotes and
T10607 21762-21766 NN denotes type
T10606 21757-21761 JJ denotes wild
T10605 21754-21756 IN denotes of
T10604 21743-21753 NN denotes parenchyma
T10603 21738-21742 NN denotes lung
T10602 21734-21737 CC denotes and
T10601 21730-21733 NNP denotes BAL
T10600 21727-21729 IN denotes in
T10599 21718-21726 VBN denotes measured
T10598 21713-21717 VBD denotes were
T10597 21707-21712 NNS denotes cells
T10596 21705-21706 NNP denotes T
T10595 21703-21704 CD denotes +
T10594 21700-21703 CD denotes CD8
T10593 21689-21699 VBG denotes expressing
T10592 21684-21688 NNP denotes IFNγ
T10591 21680-21683 CC denotes and
T10590 21678-21679 -RRB- denotes )
T10589 21675-21678 NNP denotes GrB
T10588 21674-21675 -LRB- denotes (
T10587 21672-21673 NNP denotes B
T10586 21663-21671 NNP denotes Granzyme
T10585 21654-21662 JJ denotes specific
T10584 21648-21653 NN denotes virus
T10583 21644-21647 CC denotes and
T10582 21638-21643 NNS denotes cells
T10581 21636-21637 NNP denotes T
T10580 21634-21635 CD denotes +
T10579 21631-21634 NNP denotes CD8
T10578 21625-21630 JJ denotes total
T10577 21623-21624 , denotes ,
T10576 21615-21623 NN denotes response
T10575 21611-21614 NNP denotes CTL
T10574 21601-21610 JJ denotes antiviral
T10573 21597-21600 DT denotes the
T10572 21587-21596 VBZ denotes regulates
T10571 21581-21586 NNS denotes cells
T10570 21573-21580 JJ denotes myeloid
T10569 21570-21572 IN denotes in
T10568 21559-21569 NN denotes expression
T10567 21555-21558 NNP denotes A20
T10566 21547-21554 IN denotes whether
T10565 21542-21546 VB denotes test
T10564 21539-21541 TO denotes To
T10563 21537-21538 . denotes .
T10562 21536-21537 NNP denotes ]
T10561 21534-21536 CD denotes 63
T10560 21533-21534 NNP denotes [
T10559 21531-21532 , denotes ,
T10558 21530-21531 NNP denotes ]
T10557 21528-21530 CD denotes 62
T10556 21527-21528 NNP denotes [
T10555 21525-21526 , denotes ,
T10554 21524-21525 NNP denotes ]
T10553 21522-21524 CD denotes 61
T10552 21521-21522 NNP denotes [
T10551 21519-21520 -RRB- denotes )
T10550 21516-21519 NNP denotes CTL
T10549 21515-21516 -LRB- denotes (
T10548 21509-21514 NNS denotes cells
T10547 21507-21508 NNP denotes T
T10546 21505-21506 CD denotes +
T10545 21502-21505 NNP denotes CD8
T10544 21492-21501 JJ denotes cytotoxic
T10543 21483-21491 JJ denotes specific
T11001 23969-23970 , denotes ,
T11000 23964-23969 NNP denotes IL-1β
T10999 23960-23963 CC denotes and
T10998 23956-23959 NNP denotes TNF
T10997 23954-23955 , denotes ,
T10996 23950-23954 NNP denotes IL-6
T10995 23940-23949 NNS denotes cytokines
T10994 23924-23939 JJ denotes proinflammatory
T10993 23920-23923 DT denotes the
T10992 23917-23919 IN denotes of
T10991 23910-23916 NNS denotes levels
T10990 23905-23909 RB denotes Also
T10989 23903-23904 . denotes .
T10988 23902-23903 -RRB- denotes )
T10987 23900-23902 NN denotes 4C
T10986 23893-23899 NN denotes figure
T10542 21477-21482 NN denotes virus
T10541 21474-21476 IN denotes of
T10540 21464-21473 NN denotes expansion
T10539 21457-21463 JJ denotes clonal
T10538 21453-21456 DT denotes the
T10537 21450-21452 IN denotes on
T10536 21442-21449 VBZ denotes depends
T10535 21436-21441 NNS denotes cells
T10534 21427-21435 JJ denotes infected
T10533 21423-21426 NNP denotes IAV
T10532 21420-21422 IN denotes of
T10531 21408-21419 NN denotes Elimination
T10530 21406-21407 . denotes .
T10529 21405-21406 -RRB- denotes )
T10528 21403-21405 NNP denotes 3D
T10527 21396-21402 NN denotes figure
T10526 21395-21396 -LRB- denotes (
T10525 21390-21394 NNS denotes mice
T10524 21381-21389 JJ denotes infected
T10523 21376-21380 JJ denotes mock
T10522 21373-21375 CC denotes or
T10521 21364-21372 JJ denotes infected
T10520 21360-21363 NNP denotes IAV
T10519 21352-21359 IN denotes between
T10518 21338-21351 RB denotes significantly
T10517 21331-21337 VB denotes differ
T10450 20997-21002 JJ denotes CD11b
T10449 20996-20997 -LRB- denotes (
T10448 20987-20995 NN denotes monocyte
T10447 20984-20986 IN denotes in
T10446 20975-20983 NN denotes increase
T10445 20963-20974 JJ denotes significant
T10444 20961-20962 DT denotes a
T10443 20954-20960 VB denotes detect
T10442 20948-20953 MD denotes could
T10441 20945-20947 PRP denotes we
T10440 20936-20944 IN denotes Although
T10439 20934-20935 . denotes .
T10438 20933-20934 -RRB- denotes )
T10437 20931-20933 NNP denotes 3D
T10436 20924-20930 NN denotes figure
T10435 20923-20924 -LRB- denotes (
T10434 20915-20922 NNS denotes animals
T10433 20907-20914 VB denotes control
T10432 20904-20906 TO denotes to
T10431 20895-20903 VBN denotes compared
T10430 20890-20894 NNS denotes mice
T10429 20879-20889 JJ denotes A20myel-KO
T10428 20876-20878 IN denotes in
T10427 20866-20875 NN denotes infection
T10426 20855-20865 IN denotes throughout
T10425 20848-20854 JJR denotes higher
T10424 20840-20847 RB denotes clearly
T10423 20836-20839 VBD denotes was
T10422 20826-20835 NN denotes infection
T10421 20822-20825 NNP denotes IAV
T10420 20817-20821 IN denotes upon
T10419 20810-20816 NNS denotes spaces
T10418 20794-20809 NN denotes bronchoalveolar
T10417 20790-20793 DT denotes the
T10416 20787-20789 IN denotes in
T10415 20777-20786 VBN denotes recruited
T10414 20772-20776 VBD denotes were
T10413 20767-20771 WDT denotes that
T10412 20765-20766 -RRB- denotes )
T10411 20764-20765 NNP denotes −
T10410 20759-20764 NNP denotes F4/80
T10409 20757-20758 NNP denotes +
T10408 20753-20757 NNP denotes Ly6G
T10407 20751-20752 NNP denotes +
T10406 20747-20751 NNP denotes Ly6C
T10405 20745-20746 NN denotes +
T10404 20740-20745 JJ denotes CD11b
T10403 20739-20740 -LRB- denotes (
T10402 20727-20738 NNS denotes neutrophils
T10401 20724-20726 IN denotes of
T10400 20717-20723 NN denotes number
T10399 20713-20716 DT denotes the
T10398 20711-20712 , denotes ,
T10397 20707-20711 NNS denotes mice
T10396 20696-20706 JJ denotes A20myel-KO
T10395 20693-20695 IN denotes in
T10394 20686-20692 NNS denotes levels
T10393 20680-20685 NNP denotes MIP-2
T10392 20676-20679 CC denotes and
T10391 20673-20675 NNP denotes KC
T10390 20666-20672 JJR denotes higher
T10389 20662-20665 DT denotes the
T10388 20657-20661 IN denotes with
T10387 20646-20656 JJ denotes Consistent
T10386 20644-20645 . denotes .
T10385 20643-20644 NNP denotes ]
T10384 20641-20643 CD denotes 60
T10383 20640-20641 NNP denotes [
T10382 20634-20639 NNS denotes lumen
T10381 20625-20633 JJ denotes alveolar
T10380 20621-20624 DT denotes the
T10379 20612-20620 VBG denotes entering
T10378 20607-20611 IN denotes upon
T10377 20595-20606 NNS denotes macrophages
T10376 20590-20594 IN denotes into
T10375 20582-20589 VBP denotes develop
T10374 20571-20581 RB denotes eventually
T10373 20565-20570 WDT denotes which
T10372 20563-20564 , denotes ,
T10371 20554-20563 NNS denotes monocytes
T10370 20550-20553 IN denotes for
T10369 20534-20549 NN denotes chemoattractant
T10368 20532-20533 DT denotes a
T10367 20529-20531 IN denotes as
T10366 20523-20528 VBN denotes known
T10365 20516-20522 RB denotes mainly
T10364 20513-20515 VBZ denotes is
T10363 20507-20512 NNP denotes MCP-1
T10362 20501-20506 IN denotes while
T10361 20499-20500 , denotes ,
T10360 20488-20499 NNS denotes neutrophils
T10359 20484-20487 IN denotes for
T10358 20468-20483 NN denotes chemoattractant
T10357 20466-20467 DT denotes a
T10356 20463-20465 IN denotes as
T10355 20457-20462 NN denotes MIP-2
T10354 20452-20456 IN denotes with
T10353 20443-20451 RB denotes together
T10352 20436-20442 VBZ denotes serves
T10351 20432-20435 CC denotes and
T10350 20427-20431 NN denotes IL-8
T10349 20424-20426 IN denotes of
T10348 20413-20423 NN denotes orthologue
T10347 20406-20412 NN denotes murine
T10346 20402-20405 DT denotes the
T10345 20399-20401 VBZ denotes is
T10344 20396-20398 NNP denotes KC
T10343 20394-20395 . denotes .
T10342 20393-20394 -RRB- denotes )
T10341 20391-20393 NNP denotes 3C
T10340 20384-20390 NN denotes figure
T10339 20383-20384 -LRB- denotes (
T10338 20375-20382 NNS denotes animals
T10337 20364-20374 JJ denotes A20myel-KO
T10336 20361-20363 IN denotes of
T10335 20355-20360 NNS denotes lungs
T10334 20351-20354 DT denotes the
T10333 20348-20350 IN denotes in
T10332 20337-20347 NN denotes production
T10331 20332-20336 NNP denotes IFNα
T10330 20329-20331 CC denotes or
T10329 20323-20328 NNP denotes MCP-1
T10328 20320-20322 IN denotes in
T10327 20311-20319 NN denotes increase
T10326 20299-20310 JJ denotes significant
T10325 20297-20298 DT denotes a
T10324 20290-20296 VB denotes detect
T10323 20286-20289 RB denotes not
T10322 20280-20285 MD denotes could
T10321 20277-20279 PRP denotes we
T10320 20265-20276 NNS denotes macrophages
T10319 20257-20264 JJ denotes primary
T10318 20246-20256 VBD denotes stimulated
T10317 20240-20245 NN denotes vitro
T10316 20237-20239 IN denotes in
T10315 20232-20236 IN denotes with
T10314 20219-20231 NNS denotes observations
T10313 20215-20218 PRP$ denotes our
T10312 20208-20214 IN denotes Unlike
T10311 20206-20207 . denotes .
T10310 20205-20206 -RRB- denotes )
T10309 20203-20205 NNP denotes 3C
T10308 20196-20202 NN denotes figure
T10307 20195-20196 -LRB- denotes (
T10306 20190-20194 NNS denotes mice
T10305 20185-20189 NN denotes type
T10304 20180-20184 JJ denotes wild
T10303 20171-20179 JJ denotes infected
T10302 20167-20170 NNP denotes IAV
T10301 20164-20166 TO denotes to
T10300 20155-20163 VBN denotes compared
T10299 20150-20154 NNS denotes mice
T10298 20139-20149 JJ denotes A20myel-KO
T10297 20130-20138 VBD denotes infected
T10296 20126-20129 NNP denotes IAV
T10295 20121-20125 IN denotes from
T10294 20117-20120 NNP denotes BAL
T10293 20114-20116 IN denotes in
T10292 20109-20113 NN denotes p.i.
T10291 20107-20108 CD denotes 7
T10290 20103-20106 NN denotes day
T10289 20100-20102 IN denotes at
T10288 20093-20099 JJR denotes higher
T10287 20079-20092 RB denotes significantly
T10286 20074-20078 VBD denotes were
T10285 20069-20073 NN denotes IL-6
T10284 20066-20068 IN denotes as
T10283 20061-20065 RB denotes well
T10282 20058-20060 RB denotes as
T10281 20056-20057 , denotes ,
T10280 20046-20056 NNS denotes chemokines
T10279 20040-20045 NNP denotes MIP-2
T10278 20036-20039 CC denotes and
T10277 20033-20035 NNP denotes KC
T10276 20030-20032 IN denotes of
T10275 20023-20029 NNS denotes Levels
T10274 20021-20022 . denotes .
T10273 20012-20021 NN denotes infection
T10272 20002-20011 VBG denotes following
T10271 19999-20001 CD denotes 10
T10270 19995-19998 NN denotes day
T10269 19991-19994 CC denotes and
T10268 19989-19990 CD denotes 7
T10267 19987-19988 , denotes ,
T10266 19986-19987 CD denotes 4
T10265 19982-19985 NN denotes day
T10264 19979-19981 IN denotes at
T10263 19977-19978 -RRB- denotes )
T10262 19974-19977 NNP denotes BAL
T10261 19973-19974 -LRB- denotes (
T10769 22598-22602 NNS denotes data
T10768 22592-22597 DT denotes these
T10767 22590-22591 , denotes ,
T10766 22582-22590 RB denotes Together
T10765 22580-22581 . denotes .
T10764 22575-22580 NNS denotes cells
T10763 22567-22574 JJ denotes myeloid
T10762 22564-22566 IN denotes in
T10761 22553-22563 NN denotes expression
T10760 22549-22552 NNP denotes A20
T10759 22546-22548 IN denotes by
T10758 22537-22545 VBN denotes affected
T10757 22533-22536 RB denotes not
T10756 22530-22532 VBZ denotes is
T10755 22521-22529 NN denotes immunity
T10754 22513-22520 JJ denotes humoral
T10753 22508-22512 IN denotes that
T10752 22497-22507 VBG denotes indicating
T10751 22495-22496 , denotes ,
T10750 22494-22495 -RRB- denotes )
T10749 22491-22494 NNP denotes S2D
T10748 22484-22490 NN denotes figure
T10747 22483-22484 -LRB- denotes (
T10746 22475-22482 NNS denotes animals
T10745 22464-22474 JJ denotes A20myel-KO
T10744 22460-22463 CC denotes and
T10743 22455-22459 NN denotes type
T10742 22450-22454 JJ denotes wild
T10741 22442-22449 IN denotes between
T10740 22433-22441 VBN denotes detected
T10739 22430-22432 VB denotes be
T10738 22424-22429 MD denotes could
T10737 22412-22423 NNS denotes differences
T10736 22409-22411 DT denotes no
T10735 22407-22408 , denotes ,
T10734 22400-22407 RB denotes However
T10733 22398-22399 . denotes .
T10260 19966-19972 NN denotes lavage
T10259 19950-19965 NN denotes bronchoalveolar
T10258 19946-19949 DT denotes the
T10257 19943-19945 IN denotes in
T10256 19933-19942 NNS denotes cytokines
T10255 19929-19932 CC denotes and
T10254 19918-19928 NNS denotes chemokines
T10253 19910-19917 JJ denotes several
T10252 19907-19909 IN denotes of
T10251 19900-19906 NNS denotes levels
T10250 19896-19899 DT denotes the
T10249 19887-19895 VBD denotes analyzed
T10248 19884-19886 PRP denotes we
T10247 19882-19883 , denotes ,
T10246 19878-19882 NN denotes lung
T10245 19874-19877 DT denotes the
T10244 19871-19873 IN denotes in
T10243 19860-19870 NN denotes expression
T10242 19855-19859 NN denotes gene
T10241 19843-19854 JJ denotes IAV-induced
T10240 19835-19842 VBZ denotes affects
T10239 19829-19834 NNS denotes cells
T10238 19821-19828 JJ denotes myeloid
T10237 19818-19820 IN denotes in
T10236 19807-19817 NN denotes deficiency
T10235 19803-19806 NNP denotes A20
T10194 18719-18723 IN denotes from
T10193 18710-18718 VBN denotes isolated
T10192 18707-18709 VB denotes be
T10191 18701-18706 RB denotes still
T10190 18695-18700 MD denotes could
T10189 18685-18694 NNS denotes particles
T10188 18679-18684 JJ denotes viral
T10187 18668-18678 JJ denotes infectious
T10186 18659-18667 JJ denotes abundant
T10185 18653-18658 IN denotes while
T10184 18648-18652 NNS denotes mice
T10183 18637-18647 JJ denotes A20myel-KO
T10182 18634-18636 IN denotes of
T10181 18628-18633 NNS denotes lungs
T10180 18624-18627 DT denotes the
T10179 18621-18623 IN denotes in
T10178 18612-18620 VBN denotes detected
T10177 18609-18611 VB denotes be
T10176 18603-18608 MD denotes could
T10175 18597-18602 NN denotes virus
T10174 18594-18596 DT denotes no
T10173 18587-18593 RB denotes almost
T10172 18585-18586 , denotes ,
T10171 18581-18585 NNS denotes days
T10170 18578-18580 CD denotes 10
T10169 18572-18577 IN denotes after
T10168 18570-18571 , denotes ,
T10167 18563-18570 RB denotes However
T10166 18561-18562 . denotes .
T10165 18552-18561 NN denotes infection
T10164 18547-18551 NN denotes post
T10163 18545-18546 CD denotes 7
T10162 18541-18544 CC denotes and
T10161 18539-18540 CD denotes 4
T10160 18535-18538 NN denotes day
T10159 18532-18534 IN denotes at
T10158 18527-18531 NNS denotes mice
T10157 18522-18526 NN denotes type
T10156 18517-18521 JJ denotes wild
T10155 18510-18516 CC denotes versus
T10154 18505-18509 NNS denotes mice
T10153 18494-18504 JJ denotes A20myel-KO
T10152 18491-18493 IN denotes in
T10151 18482-18490 VBN denotes observed
T10150 18477-18481 VBD denotes were
T10149 18470-18476 NNS denotes titers
T10148 18464-18469 JJ denotes viral
T10147 18461-18463 IN denotes in
T10146 18449-18460 NNS denotes differences
T10145 18446-18448 DT denotes No
T10144 18444-18445 . denotes .
T10143 18435-18444 NN denotes infection
T10142 18430-18434 NN denotes post
T10141 18425-18429 NNS denotes days
T10140 18422-18424 CD denotes 10
T10139 18418-18421 CC denotes and
T10138 18416-18417 CD denotes 7
T10137 18414-18415 , denotes ,
T10136 18413-18414 CD denotes 4
T10135 18410-18412 IN denotes at
T10134 18403-18409 NNS denotes titers
T10133 18397-18402 JJ denotes viral
T10132 18387-18396 JJ denotes pulmonary
T10131 18378-18386 VBD denotes measured
T10130 18375-18377 PRP denotes we
T10129 18373-18374 , denotes ,
T10128 18369-18373 JJ denotes Next
T10127 18367-18368 . denotes .
T10126 18366-18367 -RRB- denotes )
T10125 18361-18366 VBN denotes shown
T10124 18357-18360 RB denotes not
T10123 18352-18356 NNS denotes data
T10122 18351-18352 -LRB- denotes (
T10121 18346-18350 NNS denotes mice
T10120 18335-18345 JJ denotes A20myel-KO
T10119 18332-18334 IN denotes in
T10118 18326-18331 JJR denotes lower
T10117 18317-18325 RB denotes slightly
T10116 18313-18316 VBD denotes was
T10115 18309-18312 CC denotes and
T10114 18307-18308 , denotes ,
T10113 18303-18307 NNS denotes mice
T10112 18292-18302 JJ denotes A20myel-KO
T10111 18288-18291 CC denotes and
T10110 18283-18287 NN denotes type
T10109 18278-18282 JJ denotes wild
T10108 18273-18277 DT denotes both
T10107 18270-18272 IN denotes in
T10106 18260-18269 NN denotes infection
T10105 18255-18259 NN denotes post
T10104 18250-18254 NNS denotes days
T10103 18247-18249 CD denotes 10
T10102 18243-18246 CC denotes and
T10101 18241-18242 CD denotes 7
T10100 18238-18240 IN denotes at
T10099 18224-18237 RB denotes significantly
T10098 18214-18223 VBN denotes increased
T10097 18210-18213 VBD denotes was
T10096 18208-18209 , denotes ,
T10095 18201-18208 NN denotes leakage
T10094 18192-18200 JJ denotes vascular
T10093 18188-18191 CC denotes and
T10092 18181-18187 NN denotes damage
T10091 18176-18180 NN denotes lung
T10090 18167-18175 VBZ denotes reflects
T10089 18161-18166 WDT denotes which
T10088 18159-18160 , denotes ,
T10087 18154-18159 NN denotes fluid
T10086 18150-18153 NNP denotes BAL
T10085 18147-18149 IN denotes in
T10084 18133-18146 NN denotes concentration
T10083 18125-18132 NN denotes protein
T10082 18119-18124 JJ denotes total
T10081 18117-18118 , denotes ,
T10080 18113-18117 RB denotes Also
T10079 18111-18112 . denotes .
T10078 18110-18111 -RRB- denotes )
T10077 18108-18110 NNP denotes 3A
T10076 18101-18107 NN denotes figure
T10075 18100-18101 -LRB- denotes (
T10067 18042-18053 NNS denotes littermates
T10066 18034-18041 NN denotes control
T10065 18029-18033 NN denotes type
T10064 18024-18028 JJ denotes wild
T10063 18021-18023 TO denotes to
T10062 18012-18020 VBN denotes compared
T10061 18007-18011 NN denotes loss
T10060 18000-18006 NN denotes weight
T10059 17992-17999 VBN denotes reduced
T10058 17985-17991 VBD denotes showed
T10057 17980-17984 NNS denotes mice
T10056 17969-17979 JJ denotes A20myel-KO
T10055 17967-17968 . denotes .
T10054 17963-17967 NN denotes loss
T10053 17956-17962 NN denotes weight
T10052 17953-17955 IN denotes of
T10051 17947-17952 NNS denotes terms
T10050 17944-17946 IN denotes in
T10049 17934-17943 NN denotes morbidity
T10048 17924-17933 VBD denotes monitored
T10047 17920-17923 CC denotes and
T10046 17913-17919 NN denotes strain
T10045 17911-17912 -RRB- denotes )
T10044 17907-17911 NNP denotes H3N2
T10043 17906-17907 -LRB- denotes (
T10042 17901-17905 NNP denotes X-47
T10041 17897-17900 NNP denotes IAV
T10040 17889-17896 VBD denotes adapted
T10039 17883-17888 NN denotes mouse
T10038 17879-17882 DT denotes the
T10037 17876-17878 IN denotes of
T10036 17871-17875 NN denotes dose
T10035 17861-17870 JJ denotes sublethal
T10034 17859-17860 DT denotes a
T10033 17854-17858 IN denotes with
T10032 17842-17853 NNS denotes littermates
T10031 17834-17841 NN denotes control
T10030 17830-17833 CC denotes and
T10029 17825-17829 NNS denotes mice
T10028 17814-17824 JJ denotes A20myel-KO
T10027 17809-17813 DT denotes both
T10026 17798-17808 VBD denotes inoculated
T10025 17785-17797 RB denotes intranasally
T10024 17782-17784 PRP denotes we
T10023 17780-17781 , denotes ,
T10022 17776-17780 NN denotes vivo
T10021 17773-17775 IN denotes in
T10020 17763-17772 NN denotes infection
T10019 17759-17762 NNP denotes IAV
T10018 17756-17758 DT denotes an
T10017 17749-17755 IN denotes during
T10016 17743-17748 NNS denotes cells
T10015 17735-17742 JJ denotes myeloid
T10014 17732-17734 IN denotes in
T10013 17721-17731 NN denotes expression
T10012 17717-17720 NNP denotes A20
T10011 17714-17716 IN denotes of
T10010 17709-17713 NN denotes role
T10009 17705-17708 DT denotes the
T10008 17695-17704 VB denotes determine
T10007 17692-17694 TO denotes To
T10006 17682-17691 NN denotes infection
T10005 17677-17681 NN denotes lung
T10516 21327-21330 RB denotes not
T10515 21323-21326 VBD denotes did
T10514 21319-21322 CC denotes but
T10513 21314-21318 NNS denotes mice
T10512 21303-21313 JJ denotes A20myel-KO
T10511 21300-21302 IN denotes in
T10510 21291-21299 VBN denotes elevated
T10509 21286-21290 RB denotes also
T10508 21282-21285 VBD denotes was
T10507 21280-21281 -RRB- denotes )
T10506 21279-21280 NNP denotes −
T10505 21274-21279 NNP denotes CD11b
T10504 21272-21273 NNP denotes +
T10503 21267-21272 NNP denotes F4/80
T10502 21265-21266 NNP denotes +
T10501 21260-21265 NNP denotes CD11c
T10500 21258-21259 NN denotes +
T10499 21243-21258 JJ denotes autofluorescent
T10498 21242-21243 -LRB- denotes (
T10497 21230-21241 NNS denotes macrophages
T10496 21221-21229 NN denotes alveolar
T10495 21212-21220 NN denotes resident
T10494 21209-21211 IN denotes of
T10493 21202-21208 NN denotes number
T10492 21198-21201 DT denotes The
T10491 21196-21197 . denotes .
T10490 21192-21196 NNS denotes mice
T10489 21189-21191 IN denotes of
T10488 21182-21188 NNS denotes groups
T10487 21177-21181 DT denotes both
T10486 21174-21176 IN denotes in
T10485 21168-21173 NN denotes MCP-1
T10484 21165-21167 IN denotes of
T10483 21154-21164 NN denotes expression
T10482 21148-21153 JJ denotes equal
T10481 21144-21147 DT denotes the
T10480 21139-21143 IN denotes with
T10479 21128-21138 JJ denotes consistent
T10478 21125-21127 VBZ denotes is
T10477 21119-21124 WDT denotes which
T10476 21117-21118 , denotes ,
T10475 21116-21117 -RRB- denotes )
T10474 21114-21116 NNP denotes 3D
T10473 21107-21113 NN denotes figure
T10472 21106-21107 -LRB- denotes (
T10471 21096-21105 NN denotes infection
T10470 21090-21095 IN denotes after
T10469 21083-21089 NNS denotes points
T10468 21078-21082 NN denotes time
T10467 21072-21077 JJ denotes later
T10466 21069-21071 IN denotes at
T10465 21061-21068 JJ denotes evident
T10464 21057-21060 RB denotes not
T10463 21053-21056 VBD denotes was
T10462 21048-21052 DT denotes this
T10461 21046-21047 , denotes ,
T10460 21037-21046 NN denotes infection
T10459 21032-21036 NN denotes post
T10458 21030-21031 CD denotes 4
T10457 21026-21029 NN denotes day
T10456 21023-21025 IN denotes at
T10455 21011-21022 NN denotes recruitment
T10454 21009-21010 -RRB- denotes )
T10453 21008-21009 NNP denotes +
T10452 21004-21008 NNP denotes Ly6C
T10451 21002-21003 NN denotes +
T10004 17673-17676 NNP denotes IAV
T10003 17665-17672 IN denotes against
T10234 19800-19802 IN denotes if
T10233 19793-19799 VB denotes verify
T10232 19790-19792 TO denotes To
T10231 18921-18922 . denotes .
T10230 18912-18921 NN denotes infection
T10229 18905-18911 IN denotes during
T10228 18898-18904 NNS denotes stages
T10227 18892-18897 JJ denotes later
T10226 18889-18891 IN denotes at
T10225 18879-18888 NN denotes clearance
T10224 18873-18878 JJ denotes viral
T10223 18870-18872 TO denotes to
T10222 18858-18869 VBZ denotes contributes
T10221 18854-18857 CC denotes but
T10220 18842-18853 NN denotes replication
T10219 18836-18841 JJ denotes viral
T10218 18830-18835 JJ denotes early
T10217 18823-18829 VB denotes affect
T10216 18819-18822 RB denotes not
T10215 18814-18818 VBZ denotes does
T10214 18808-18813 NNS denotes cells
T10213 18800-18807 JJ denotes myeloid
T10212 18797-18799 IN denotes in
T10211 18793-18796 NNP denotes A20
T10210 18790-18792 IN denotes of
T10209 18785-18789 NN denotes loss
T10208 18780-18784 IN denotes that
T10207 18770-18779 VBZ denotes indicates
T10206 18765-18769 DT denotes This
T10205 18763-18764 . denotes .
T10204 18762-18763 -RRB- denotes )
T10203 18760-18762 NN denotes 3B
T10202 18753-18759 NN denotes figure
T10201 18752-18753 -LRB- denotes (
T10200 18747-18751 NNS denotes mice
T10199 18742-18746 NN denotes type
T10198 18737-18741 JJ denotes wild
T10197 18733-18736 DT denotes all
T10196 18730-18732 IN denotes of
T10195 18724-18729 NNS denotes lungs
T8341 17621-17622 . denotes .
T8340 17611-17621 NN denotes activation
T8339 17606-17610 JJ denotes IRF3
T8338 17602-17605 CC denotes and
T8337 17596-17601 NN denotes NF-κB
T8336 17582-17595 JJ denotes RIG-I-induced
T8335 17579-17581 IN denotes on
T8334 17574-17578 VBN denotes seen
T8333 17570-17573 NNP denotes A20
T8332 17567-17569 IN denotes of
T8331 17560-17566 NN denotes effect
T8330 17549-17559 JJ denotes inhibitory
T8329 17545-17548 DT denotes the
T8328 17540-17544 IN denotes with
T8327 17529-17539 JJ denotes consistent
T8326 17527-17528 , denotes ,
T8325 17516-17527 NNS denotes macrophages
T8324 17507-17515 JJ denotes alveolar
T8323 17504-17506 IN denotes in
T8322 17493-17503 NN denotes expression
T8321 17488-17492 NN denotes gene
T8320 17478-17487 JJ denotes antiviral
T8319 17474-17477 CC denotes and
T8318 17458-17473 JJ denotes proinflammatory
T8317 17446-17457 JJ denotes IAV-induced
T8316 17436-17445 VBZ denotes regulates
T8315 17425-17435 RB denotes negatively
T8314 17421-17424 CD denotes A20
T8313 17416-17420 IN denotes that
T8241 17017-17022 NNS denotes lungs
T8240 17012-17016 IN denotes from
T8239 17006-17011 NNS denotes cells
T8238 17000-17005 DT denotes these
T8237 16991-16999 VBD denotes isolated
T8236 16988-16990 PRP denotes we
T8235 16986-16987 , denotes ,
T8234 16975-16986 NNS denotes macrophages
T8233 16966-16974 JJ denotes alveolar
T8232 16963-16965 IN denotes in
T8231 16952-16962 NN denotes expression
T8230 16947-16951 NN denotes gene
T8229 16935-16946 JJ denotes IAV-induced
T8228 16926-16934 VBZ denotes controls
T8227 16917-16925 RB denotes directly
T8226 16913-16916 NNP denotes A20
T8225 16905-16912 IN denotes whether
T8224 16900-16904 VB denotes test
T8223 16897-16899 TO denotes To
T8222 16895-16896 . denotes .
T8221 16886-16895 NN denotes infection
T8220 16883-16885 IN denotes of
T8219 16877-16882 NN denotes phase
T8218 16869-16876 JJ denotes primary
T8217 16865-16868 DT denotes the
T8216 16858-16864 IN denotes during
T8215 16853-16857 NN denotes lung
T8214 16849-16852 DT denotes the
T8213 16846-16848 TO denotes to
T8212 16840-16845 NNS denotes cells
T8211 16833-16839 JJ denotes immune
T8210 16826-16832 JJ denotes innate
T8209 16815-16825 VBG denotes attracting
T8208 16813-16814 , denotes ,
T8207 16803-16813 NNS denotes chemokines
T8206 16799-16802 CC denotes and
T8205 16789-16798 NNS denotes cytokines
T8204 16786-16788 IN denotes of
T8203 16779-16785 NN denotes source
T8202 16769-16778 JJ denotes important
T8201 16766-16768 DT denotes an
T8200 16762-16765 VBP denotes are
T8199 16750-16761 NNS denotes macrophages
T8198 16741-16749 JJ denotes alveolar
T8197 16739-16740 , denotes ,
T8196 16736-16739 NNP denotes IAV
T8195 16731-16735 IN denotes with
T8194 16721-16730 NN denotes infection
T8193 16716-16720 NN denotes host
T8192 16711-16715 IN denotes Upon
T8191 15830-15831 . denotes .
T8190 15829-15830 -RRB- denotes )
T8189 15827-15829 NN denotes 2B
T8188 15820-15826 NN denotes figure
T8187 15819-15820 -LRB- denotes (
T8186 15814-15818 NNP denotes IFNβ
T8185 15810-15813 CC denotes and
T8184 15806-15809 NNP denotes TNF
T8183 15803-15805 IN denotes of
T8182 15796-15802 NNS denotes levels
T8181 15789-15795 JJR denotes higher
T8180 15779-15788 VBD denotes contained
T8179 15773-15778 NNS denotes cells
T8178 15767-15772 DT denotes these
T8177 15762-15766 IN denotes from
T8176 15752-15761 VBN denotes collected
T8175 15740-15751 JJ denotes supernatant
T8174 15732-15739 NN denotes culture
T8173 15727-15731 NN denotes cell
T8172 15725-15726 , denotes ,
T8171 15721-15725 NNS denotes data
T8170 15715-15720 DT denotes these
T8169 15710-15714 IN denotes with
T8168 15699-15709 NN denotes accordance
T8167 15696-15698 IN denotes In
T8166 15694-15695 . denotes .
T8165 15693-15694 -RRB- denotes )
T8164 15691-15693 NN denotes 2A
T8163 15684-15690 NN denotes figure
T8162 15683-15684 -LRB- denotes (
T8161 15677-15682 NNS denotes cells
T8160 15669-15676 VB denotes control
T8159 15666-15668 TO denotes to
T8158 15657-15665 VBN denotes compared
T8157 15647-15656 NN denotes infection
T8156 15643-15646 NNP denotes IAV
T8155 15637-15642 IN denotes after
T8154 15632-15636 NNP denotes mRNA
T8153 15627-15631 NNP denotes IFNβ
T8152 15623-15626 CC denotes and
T8151 15618-15622 NNP denotes IL-6
T8150 15615-15617 IN denotes of
T8149 15604-15614 NN denotes expression
T8148 15595-15603 JJ denotes enhanced
T8147 15590-15594 NN denotes show
T8146 15585-15589 NNP denotes BMDM
T8145 15574-15584 JJ denotes A20myel-KO
T8144 15572-15573 , denotes ,
T8143 15561-15572 RB denotes Furthermore
T8142 15559-15560 . denotes .
T8141 15558-15559 -RRB- denotes )
T8140 15556-15558 NN denotes 2A
T8139 15549-15555 NN denotes figure
T8138 15548-15549 -LRB- denotes (
T8137 15538-15547 NN denotes infection
T8136 15532-15537 JJ denotes viral
T8135 15527-15531 IN denotes upon
T8134 15525-15526 , denotes ,
T8133 15521-15525 NNP denotes BMDM
T8132 15511-15520 JJ denotes deficient
T8131 15507-15510 CD denotes A20
T8130 15504-15506 IN denotes in
T8129 15500-15503 RB denotes not
T8128 15496-15499 CC denotes but
T8127 15494-15495 , denotes ,
T8126 15490-15494 NNP denotes BMDM
T8125 15485-15489 NN denotes type
T8124 15480-15484 JJ denotes wild
T8123 15477-15479 IN denotes in
T8122 15469-15476 VBN denotes induced
T8121 15461-15468 RB denotes rapidly
T8120 15456-15460 VBD denotes were
T8119 15449-15455 NNS denotes levels
T8118 15444-15448 NNP denotes mRNA
T8117 15440-15443 CD denotes A20
T8116 15438-15439 . denotes .
T8115 15437-15438 -RRB- denotes )
T8114 15433-15437 NNP denotes H3N2
T8113 15432-15433 -LRB- denotes (
T8112 15427-15431 NNP denotes X-47
T8111 15423-15426 NNP denotes IAV
T8110 15418-15422 IN denotes with
T8109 15413-15417 NNP denotes BMDM
T8108 15405-15412 NN denotes control
T8107 15401-15404 CC denotes and
T8106 15391-15400 NN denotes deficient
T8105 15387-15390 NNP denotes A20
T8104 15378-15386 VBD denotes infected
T8103 15375-15377 PRP denotes we
T8102 15373-15374 , denotes ,
T8101 15364-15373 NNS denotes responses
T8100 15357-15363 JJ denotes immune
T8099 15350-15356 NN denotes innate
T8098 15340-15349 JJ denotes antiviral
T8097 15336-15339 CC denotes and
T8096 15320-15335 JJ denotes proinflammatory
T8095 15308-15319 JJ denotes IAV-induced
T8094 15304-15307 DT denotes the
T8093 15301-15303 IN denotes in
T8092 15297-15300 NNP denotes A20
T8091 15294-15296 IN denotes of
T8090 15289-15293 NN denotes role
T8089 15285-15288 DT denotes the
T8088 15273-15284 VB denotes investigate
T8087 15270-15272 TO denotes To
T8086 15265-15269 NNP denotes BMDM
T8085 15262-15264 IN denotes in
T8084 15251-15261 NN denotes expression
T8083 15246-15250 NN denotes gene
T8082 15234-15245 JJ denotes IAV-induced
T8081 15224-15233 VBZ denotes regulates
T8080 15213-15223 RB denotes negatively
T8079 15209-15212 CD denotes A20
T8312 17404-17415 VBP denotes demonstrate
T8311 17396-17403 NNS denotes results
T8310 17390-17395 DT denotes these
T8309 17381-17389 RB denotes together
T8308 17375-17380 VBN denotes Taken
T8307 17373-17374 . denotes .
T8306 17372-17373 -RRB- denotes )
T8305 17370-17372 CD denotes S1
T8304 17363-17369 NN denotes figure
T8303 17359-17362 CC denotes and
T8302 17356-17358 NN denotes 2C
T8301 17349-17355 NN denotes figure
T8300 17348-17349 -LRB- denotes (
T8299 17342-17347 NNS denotes cells
T8298 17337-17341 NN denotes type
T8297 17332-17336 JJ denotes wild
T8296 17323-17331 JJ denotes infected
T8295 17320-17322 TO denotes to
T8294 17311-17319 VBN denotes compared
T8293 17307-17310 NNP denotes A20
T8292 17299-17306 VBG denotes lacking
T8291 17293-17298 NNS denotes cells
T8290 17284-17292 JJ denotes infected
T8289 17280-17283 NNP denotes IAV
T8288 17277-17279 IN denotes in
T8287 17270-17276 JJR denotes higher
T8286 17256-17269 RB denotes significantly
T8285 17252-17255 VBD denotes was
T8284 17250-17251 -RRB- denotes )
T8283 17245-17250 CD denotes cxcl1
T8282 17244-17245 -LRB- denotes (
T8281 17241-17243 NNP denotes KC
T8280 17237-17240 CC denotes and
T8279 17235-17236 -RRB- denotes )
T8278 17231-17235 CD denotes ccl2
T8277 17230-17231 -LRB- denotes (
T8276 17224-17229 NNP denotes MCP-1
T8275 17213-17223 NNS denotes chemokines
T8274 17209-17212 DT denotes the
T8273 17205-17208 CC denotes and
T8272 17199-17204 NNP denotes IFNα4
T8271 17195-17198 CC denotes and
T8270 17190-17194 NNP denotes IFNβ
T8269 17186-17189 NNP denotes IFN
T8268 17179-17185 NNP denotes type-I
T8267 17175-17178 DT denotes the
T8266 17173-17174 , denotes ,
T8265 17170-17173 NNP denotes TNF
T8264 17166-17169 CC denotes and
T8263 17161-17165 NNP denotes IL-6
T8262 17151-17160 NNS denotes cytokines
T8261 17135-17150 JJ denotes proinflammatory
T8260 17131-17134 DT denotes the
T8259 17128-17130 IN denotes of
T8258 17118-17127 NN denotes secretion
T8257 17114-17117 CC denotes and
T8256 17103-17113 NN denotes Expression
T8255 17101-17102 . denotes .
T8254 17097-17101 NNP denotes X-47
T8253 17093-17096 NNP denotes IAV
T8252 17088-17092 IN denotes with
T8251 17082-17087 NN denotes vitro
T8250 17079-17081 IN denotes in
T8249 17074-17078 PRP denotes them
T8248 17065-17073 VBD denotes infected
T8247 17061-17064 CC denotes and
T8246 17049-17060 NNS denotes littermates
T8245 17041-17048 NN denotes control
T8244 17037-17040 CC denotes and
T8243 17026-17036 JJ denotes A20myel-KO
T8242 17023-17025 IN denotes of
T6602 14984-14988 VBD denotes were
T6601 14976-14983 NNS denotes results
T6600 14968-14975 JJ denotes Similar
T6599 14966-14967 . denotes .
T6598 14965-14966 -RRB- denotes )
T6597 14963-14965 VBN denotes 1D
T6596 14956-14962 NN denotes figure
T6595 14955-14956 -LRB- denotes (
T6594 14950-14954 NNP denotes IFNβ
T6593 14946-14949 CC denotes and
T6592 14942-14945 NNP denotes TNF
T6591 14940-14941 , denotes ,
T6590 14936-14940 NNP denotes IL-6
T6589 14933-14935 IN denotes of
T6588 14925-14932 NNS denotes amounts
T6587 14915-14924 VBN denotes increased
T6586 14906-14914 VBD denotes secreted
T6585 14901-14905 NNP denotes BMDM
T6584 14890-14900 JJ denotes A20myel-KO
T6583 14888-14889 , denotes ,
T6582 14883-14888 IN denotes above
T6581 14873-14882 VBN denotes described
T6580 14870-14872 IN denotes as
T6579 14865-14869 NNP denotes IRF3
T6578 14861-14864 CC denotes and
T6577 14855-14860 NNP denotes NF-κB
T6576 14852-14854 IN denotes of
T6575 14841-14851 NN denotes activation
T6574 14832-14840 JJ denotes enhanced
T6573 14828-14831 DT denotes the
T6572 14823-14827 IN denotes with
T6571 14818-14822 NN denotes line
T6570 14815-14817 IN denotes In
T6569 14813-14814 . denotes .
T6568 14809-14813 NNP denotes IFNβ
T6567 14806-14808 IN denotes of
T6566 14795-14805 NN denotes expression
T6565 14791-14794 DT denotes the
T6564 14783-14790 VBP denotes control
T6563 14778-14782 NNP denotes IRF3
T6562 14774-14777 CC denotes and
T6561 14768-14773 NNP denotes NF-κB
T6560 14764-14767 CC denotes and
T6559 14762-14763 , denotes ,
T6558 14759-14762 NNP denotes TNF
T6557 14755-14758 CC denotes and
T6556 14750-14754 NNP denotes IL-6
T6555 14747-14749 IN denotes of
T6554 14736-14746 NN denotes expression
T6553 14732-14735 DT denotes the
T6552 14723-14731 VBZ denotes controls
T6551 14717-14722 NN denotes NF-κB
T6550 14715-14716 . denotes .
T6549 14714-14715 -RRB- denotes )
T6369 13718-13719 DT denotes a
T6368 13708-13717 VBZ denotes undergoes
T6367 13704-13707 NNP denotes A20
T6366 13699-13703 IN denotes that
T6365 13688-13698 VBG denotes indicating
T6364 13686-13687 , denotes ,
T6363 13678-13686 VBN denotes observed
T6362 13673-13677 VBD denotes were
T6361 13669-13672 CD denotes A20
T6360 13666-13668 IN denotes of
T6359 13660-13665 NNS denotes forms
T6358 13650-13659 NN denotes migrating
T6357 13643-13649 JJR denotes slower
T6356 13634-13642 RB denotes slightly
T6355 13632-13633 , denotes ,
T6354 13626-13632 NNS denotes points
T6353 13621-13625 NN denotes time
T6352 13615-13620 JJ denotes early
T6351 13612-13614 IN denotes At
T6350 13610-13611 . denotes .
T6349 13609-13610 -RRB- denotes )
T6348 13604-13609 NN denotes panel
T6347 13598-13603 JJ denotes upper
T6346 13596-13597 , denotes ,
T6345 13594-13596 NN denotes 1B
T6344 13587-13593 NN denotes figure
T6343 13586-13587 -LRB- denotes (
T6342 13581-13585 NNP denotes BMDM
T6341 13570-13580 JJ denotes A20myel-KO
T6340 13567-13569 IN denotes in
T6339 13563-13566 RB denotes not
T6338 13559-13562 CC denotes but
T6337 13557-13558 , denotes ,
T6336 13553-13557 NN denotes type
T6335 13548-13552 JJ denotes wild
T6334 13545-13547 IN denotes in
T6333 13541-13544 NNP denotes A20
T6332 13538-13540 IN denotes of
T6331 13527-13537 NN denotes expression
T6330 13521-13526 JJ denotes rapid
T6329 13517-13520 DT denotes the
T6328 13509-13516 VBD denotes induced
T6327 13496-13508 NN denotes transfection
T6326 13494-13495 -RRB- denotes )
T6325 13493-13494 NNP denotes C
T6324 13492-13493 : denotes :
T6323 13491-13492 PRP denotes I
T6322 13490-13491 -LRB- denotes (
T6321 13486-13490 NN denotes poly
T6320 13484-13485 , denotes ,
T6319 13476-13484 VBN denotes expected
T6318 13473-13475 IN denotes As
T6317 13471-13472 . denotes .
T6316 13470-13471 -RRB- denotes )
T6315 13465-13470 VBN denotes shown
T6314 13461-13464 RB denotes not
T6313 13456-13460 NNS denotes data
T6312 13455-13456 -LRB- denotes (
T6311 13444-13454 NN denotes production
T6310 13435-13443 NN denotes cytokine
T6309 13432-13434 CC denotes or
T6308 13421-13431 NN denotes activation
T6307 13416-13420 JJ denotes IRF3
T6306 13412-13415 CC denotes and
T6305 13406-13411 NN denotes NF-κB
T6304 13396-13405 JJ denotes dependent
T6303 13391-13395 CD denotes TLR3
T6302 13379-13390 JJ denotes significant
T6301 13372-13378 VB denotes induce
T6300 13369-13371 TO denotes to
T6299 13362-13368 JJ denotes unable
T6298 13358-13361 VBD denotes was
T6297 13356-13357 -RRB- denotes )
T6296 13355-13356 NNP denotes C
T6295 13354-13355 : denotes :
T6294 13353-13354 PRP denotes I
T6293 13352-13353 -LRB- denotes (
T6292 13348-13352 NN denotes poly
T6291 13345-13347 IN denotes of
T6290 13331-13344 NN denotes concentration
T6289 13326-13330 DT denotes this
T6288 13324-13325 , denotes ,
T6287 13320-13324 NN denotes note
T6286 13317-13319 IN denotes Of
T6285 13315-13316 . denotes .
T6284 13314-13315 NNP denotes ]
T6283 13312-13314 CD denotes 57
T6282 13311-13312 NNP denotes [
T6281 13306-13310 CD denotes MDA5
T6280 13301-13305 IN denotes than
T6279 13294-13300 RB denotes rather
T6278 13288-13293 NNP denotes RIG-I
T6277 13279-13287 VB denotes activate
T6276 13275-13278 CC denotes and
T6275 13270-13274 NN denotes bind
T6274 13255-13269 RB denotes preferentially
T6273 13252-13254 TO denotes to
T6272 13246-13251 VBN denotes known
T6271 13243-13245 VBZ denotes is
T6270 13237-13242 WDT denotes which
T6269 13235-13236 , denotes ,
T6268 13234-13235 -RRB- denotes )
T6267 13233-13234 NNP denotes C
T6266 13232-13233 : denotes :
T6265 13231-13232 PRP denotes I
T6264 13230-13231 -LRB- denotes (
T6263 13226-13230 NN denotes poly
T6262 13224-13225 -RRB- denotes )
T6261 13221-13224 NNP denotes LMW
T6260 13220-13221 -LRB- denotes (
T6259 13213-13219 NN denotes weight
T6258 13203-13212 JJ denotes molecular
T6257 13199-13202 JJ denotes low
T6256 13196-13198 IN denotes of
T6255 13188-13195 NNS denotes amounts
T6254 13180-13187 JJ denotes minimal
T6253 13175-13179 IN denotes with
T6252 13169-13174 NNS denotes cells
T6251 13161-13168 NN denotes control
T6250 13156-13160 NN denotes type
T6249 13151-13155 JJ denotes wild
T6248 13147-13150 CC denotes and
T6247 13142-13146 NNP denotes BMDM
T6246 13131-13141 JJ denotes A20myel-KO
T6245 13119-13130 VBD denotes transfected
T6244 13116-13118 PRP denotes we
T6243 13114-13115 , denotes ,
T6242 13106-13114 NN denotes receptor
T6241 13100-13105 NN denotes RIG-I
T6240 13096-13099 DT denotes the
T6239 13086-13095 VB denotes stimulate
T6238 13083-13085 TO denotes To
T6237 13081-13082 . denotes .
T6236 13080-13081 NNP denotes ]
T6235 13078-13080 CD denotes 48
T6234 13077-13078 VBP denotes [
T6233 13072-13076 NNS denotes mice
T6232 13063-13071 NN denotes knockout
T6231 13059-13062 NNP denotes A20
T6230 13050-13058 JJ denotes specific
T6229 13045-13049 NN denotes cell
T6228 13037-13044 JJ denotes myeloid
T6227 13028-13036 VB denotes generate
T6226 13025-13027 TO denotes to
T6225 13022-13024 PRP denotes us
T6224 13014-13021 VBD denotes allowed
T6223 13010-13013 CC denotes and
T6222 13004-13009 NNS denotes cells
T6221 12996-13003 JJ denotes myeloid
T6220 12993-12995 IN denotes in
T6219 12984-12992 NN denotes deletion
T6218 12975-12983 JJ denotes specific
T6217 12972-12974 TO denotes to
T6216 12966-12971 VBZ denotes leads
T6215 12957-12965 NN denotes promoter
T6214 12955-12956 NNP denotes M
T6213 12946-12954 NN denotes lysozyme
T6212 12942-12945 DT denotes the
T6211 12939-12941 IN denotes of
T6210 12931-12938 NN denotes control
T6209 12925-12930 IN denotes under
T6208 12913-12924 NN denotes recombinase
T6207 12909-12912 NNP denotes Cre
T6206 12898-12908 VBG denotes expressing
T6205 12893-12897 NNS denotes mice
T6204 12882-12892 JJ denotes transgenic
T6203 12877-12881 IN denotes with
T6202 12872-12876 NNS denotes mice
T6201 12866-12871 DT denotes these
T6200 12857-12865 VBG denotes Crossing
T6199 12855-12856 . denotes .
T6198 12854-12855 NNP denotes ]
T6197 12852-12854 CD denotes 56
T6196 12851-12852 NNP denotes [
T6195 12845-12850 NNS denotes sites
T6194 12840-12844 NNP denotes loxP
T6193 12836-12839 CD denotes two
T6192 12833-12835 IN denotes by
T6191 12825-12832 VBN denotes flanked
T6190 12820-12824 VBD denotes were
T6189 12818-12819 NNP denotes V
T6188 12813-12817 VB denotes exon
T6187 12809-12812 CC denotes and
T6186 12806-12808 NNP denotes IV
T6185 12801-12805 NN denotes exon
T6184 12795-12800 WDT denotes which
T6183 12792-12794 IN denotes in
T6182 12785-12791 NN denotes allele
T6181 12781-12784 NNP denotes A20
T6180 12769-12780 JJ denotes conditional
T6179 12767-12768 DT denotes a
T6178 12758-12766 VBG denotes carrying
T6177 12753-12757 NNS denotes mice
T6176 12743-12752 VBD denotes generated
T6175 12740-12742 PRP denotes we
T6174 12738-12739 , denotes ,
T6173 12737-12738 NNP denotes ]
T6172 12735-12737 CD denotes 37
T6171 12734-12735 NNP denotes [
T6170 12721-12733 NN denotes inflammation
T6169 12709-12720 JJ denotes multi-organ
T6168 12702-12708 JJ denotes severe
T6167 12699-12701 IN denotes of
T6166 12692-12698 NN denotes result
T6165 12690-12691 DT denotes a
T6164 12687-12689 IN denotes as
T6163 12675-12686 RB denotes prematurely
T6162 12671-12674 VBP denotes die
T6161 12666-12670 NNS denotes mice
T6160 12657-12665 NN denotes knockout
T6159 12652-12656 JJ denotes full
T6158 12648-12651 NNP denotes A20
T6157 12642-12647 IN denotes Since
T6156 12640-12641 . denotes .
T6155 12629-12640 NNS denotes macrophages
T6154 12621-12628 JJ denotes primary
T6526 14582-14586 JJ denotes IRF3
T6525 14580-14581 , denotes ,
T6524 14577-14580 VB denotes p65
T6523 14574-14576 TO denotes to
T6522 14566-14573 JJ denotes Similar
T6521 14564-14565 . denotes .
T6520 14563-14564 -RRB- denotes )
T6519 14561-14563 NN denotes 1B
T6518 14554-14560 NN denotes figure
T6517 14553-14554 -LRB- denotes (
T6516 14548-14552 NNP denotes BMDM
T6515 14543-14547 NN denotes type
T6514 14538-14542 JJ denotes wild
T6513 14535-14537 TO denotes to
T6512 14526-14534 VBN denotes compared
T6511 14521-14525 NNP denotes BMDM
T6510 14510-14520 JJ denotes A20myel-KO
T6509 14507-14509 IN denotes in
T6508 14500-14506 NNS denotes points
T6507 14495-14499 NN denotes time
T6506 14487-14494 JJR denotes earlier
T6505 14484-14486 IN denotes at
T6504 14475-14483 VBN denotes detected
T6503 14471-14474 VBD denotes was
T6502 14455-14470 NN denotes phosphorylation
T6501 14450-14454 CD denotes IRF3
T6500 14442-14449 NN denotes maximum
T6499 14440-14441 , denotes ,
T6498 14434-14440 NNP denotes Ser396
T6497 14419-14433 VBN denotes phosphorylated
T6496 14411-14418 IN denotes against
T6495 14402-14410 VBN denotes directed
T6494 14393-14401 NN denotes antibody
T6493 14390-14392 DT denotes an
T6492 14385-14389 IN denotes with
T6491 14370-14384 VBG denotes immunoblotting
T6490 14364-14369 VBG denotes Using
T6489 14362-14363 . denotes .
T6488 14361-14362 NNP denotes ]
T6487 14359-14361 CD denotes 59
T6486 14358-14359 NNP denotes [
T6485 14350-14357 NN denotes nucleus
T6484 14346-14349 DT denotes the
T6483 14343-14345 TO denotes to
T6482 14329-14342 NN denotes translocation
T6481 14318-14328 JJ denotes subsequent
T6480 14314-14317 CC denotes and
T6479 14301-14313 NN denotes dimerization
T6478 14297-14300 PRP$ denotes its
T6477 14294-14296 TO denotes to
T6476 14286-14293 VBG denotes leading
T6475 14284-14285 , denotes ,
T6474 14283-14284 NNP denotes ]
T6473 14281-14283 CD denotes 58
T6472 14280-14281 NNP denotes [
T6471 14275-14279 NNP denotes IKKε
T6470 14271-14274 CC denotes and
T6469 14266-14270 CD denotes TBK1
T6468 14258-14265 NNS denotes kinases
T6467 14249-14257 JJ denotes IKK-like
T6466 14245-14248 DT denotes the
T6465 14242-14244 IN denotes by
T6464 14233-14241 NNS denotes residues
T6463 14226-14232 NN denotes serine
T6462 14217-14225 NN denotes terminal
T6461 14208-14216 NN denotes carboxyl
T6460 14205-14207 IN denotes of
T6459 14198-14204 NN denotes series
T6458 14196-14197 DT denotes a
T6457 14193-14195 IN denotes of
T6456 14177-14192 NN denotes phosphorylation
T6455 14172-14176 IN denotes upon
T6454 14162-14171 VBN denotes activated
T6453 14159-14161 VB denotes be
T6452 14156-14158 TO denotes to
T6451 14150-14155 VBN denotes known
T6450 14147-14149 VBZ denotes is
T6449 14142-14146 CD denotes IRF3
T6448 14140-14141 . denotes .
T6447 14139-14140 -RRB- denotes )
T6446 14137-14139 NNP denotes 1C
T6445 14130-14136 NN denotes figure
T6444 14129-14130 -LRB- denotes (
T6443 14123-14128 NNS denotes cells
T6442 14118-14122 NN denotes type
T6441 14113-14117 JJ denotes wild
T6440 14110-14112 TO denotes to
T6439 14101-14109 VBN denotes compared
T6438 14094-14100 NNS denotes points
T6437 14089-14093 NN denotes time
T6436 14081-14088 JJR denotes earlier
T6435 14078-14080 IN denotes at
T6434 14070-14077 NN denotes maximum
T6433 14068-14069 DT denotes a
T6432 14059-14067 VBG denotes reaching
T6431 14057-14058 , denotes ,
T6430 14053-14057 NNP denotes BMDM
T6429 14042-14052 JJ denotes A20myel-KO
T6428 14030-14041 VBN denotes transfected
T6427 14028-14029 -RRB- denotes )
T6426 14027-14028 NNP denotes C
T6425 14026-14027 : denotes :
T6424 14025-14026 PRP denotes I
T6423 14024-14025 -LRB- denotes (
T6422 14020-14024 NN denotes poly
T6421 14017-14019 IN denotes in
T6420 14008-14016 VBN denotes enhanced
T6419 14004-14007 VBD denotes was
T6418 13996-14003 NN denotes subunit
T6417 13990-13995 NN denotes NF-κB
T6416 13986-13989 CD denotes p65
T6415 13982-13985 DT denotes the
T6414 13979-13981 IN denotes of
T6413 13965-13978 NN denotes translocation
T6412 13957-13964 JJ denotes nuclear
T6411 13955-13956 , denotes ,
T6410 13944-13955 RB denotes Furthermore
T6409 13942-13943 . denotes .
T6408 13941-13942 -RRB- denotes )
T6407 13939-13941 NN denotes 1B
T6406 13932-13938 NN denotes figure
T6405 13931-13932 -LRB- denotes (
T6404 13926-13930 NNP denotes IκBα
T6403 13923-13925 IN denotes of
T6402 13911-13922 NN denotes degradation
T6401 13901-13910 VBD denotes sustained
T6400 13897-13900 CC denotes and
T6399 13881-13896 NN denotes phosphorylation
T6398 13871-13880 VBN denotes increased
T6397 13868-13870 IN denotes by
T6396 13858-13867 VBN denotes indicated
T6395 13855-13857 IN denotes as
T6394 13844-13854 NN denotes activation
T6393 13838-13843 NN denotes NF-κB
T6392 13829-13837 JJ denotes enhanced
T6391 13822-13828 VBD denotes showed
T6390 13816-13821 NNS denotes cells
T6389 13806-13815 JJ denotes deficient
T6388 13802-13805 NNP denotes A20
T6387 13800-13801 , denotes ,
T6386 13796-13800 NNP denotes BMBM
T6385 13791-13795 NN denotes type
T6384 13786-13790 JJ denotes wild
T6383 13783-13785 TO denotes to
T6382 13774-13782 VBN denotes Compared
T6381 13772-13773 . denotes .
T6380 13760-13772 NN denotes transfection
T6379 13758-13759 -RRB- denotes )
T6378 13757-13758 NNP denotes C
T6377 13756-13757 : denotes :
T6376 13755-13756 PRP denotes I
T6375 13754-13755 -LRB- denotes (
T6374 13750-13754 NN denotes poly
T6373 13745-13749 IN denotes upon
T6372 13732-13744 NN denotes modification
T6371 13724-13731 JJ denotes unknown
T6370 13720-13723 RB denotes yet
T6152 12607-12610 NNP denotes A20
T6151 12604-12606 IN denotes in
T6150 12592-12603 NNS denotes experiments
T6149 12584-12591 JJ denotes further
T6148 12574-12583 VBD denotes performed
T6147 12571-12573 PRP denotes we
T6146 12569-12570 , denotes ,
T6145 12562-12569 NN denotes context
T6144 12553-12561 JJ denotes relevant
T6143 12539-12552 JJ denotes immunological
T6142 12534-12538 RBR denotes more
T6141 12532-12533 DT denotes a
T6140 12529-12531 IN denotes in
T6139 12519-12528 VBG denotes signaling
T6138 12505-12518 JJ denotes RIG-I-induced
T6137 12502-12504 IN denotes on
T6136 12498-12501 NNP denotes A20
T6135 12488-12497 VBN denotes expressed
T6134 12475-12487 RB denotes endogenously
T6133 12472-12474 IN denotes of
T6132 12465-12471 NN denotes effect
T6131 12461-12464 DT denotes the
T6130 12455-12460 VB denotes study
T6129 12452-12454 TO denotes To
T6128 11080-11081 . denotes .
T6127 11070-11080 NN denotes activation
T6126 11063-11069 NNP denotes IRF3/7
T6125 11059-11062 CC denotes and
T6124 11053-11058 NN denotes NF-κB
T6123 11039-11052 JJ denotes RIG-I-induced
T6122 11031-11038 VB denotes inhibit
T6121 11028-11030 TO denotes to
T6120 11024-11027 CD denotes A20
T6119 11021-11023 IN denotes of
T6118 11011-11020 NN denotes potential
T6117 11007-11010 DT denotes the
T6116 10995-11006 VBP denotes demonstrate
T6115 10987-10994 NNS denotes results
T6114 10981-10986 DT denotes These
T6113 10979-10980 . denotes .
T6112 10978-10979 -RRB- denotes )
T6111 10973-10978 NN denotes graph
T6110 10967-10972 JJ denotes right
T6109 10965-10966 , denotes ,
T6108 10963-10965 NNP denotes 1A
T6107 10956-10962 NN denotes figure
T6106 10955-10956 -LRB- denotes (
T6105 10944-10954 NN denotes activation
T6104 10939-10943 NNP denotes IRF7
T6103 10925-10938 JJ denotes RIG-I-induced
T6102 10915-10924 VBD denotes prevented
T6101 10910-10914 RB denotes also
T6100 10906-10909 NNP denotes A20
T6099 10904-10905 , denotes ,
T6098 10894-10904 NN denotes activation
T6097 10889-10893 NNP denotes IRF3
T6096 10885-10888 CC denotes and
T6095 10879-10884 NNP denotes NF-κB
T6094 10876-10878 IN denotes on
T6093 10869-10875 NN denotes effect
T6092 10858-10868 JJ denotes inhibitory
T6091 10854-10857 PRP$ denotes its
T6090 10851-10853 TO denotes to
T6089 10843-10850 JJ denotes Similar
T6088 10841-10842 . denotes .
T6087 10837-10841 NNP denotes IRF7
T6086 10834-10836 IN denotes of
T6085 10825-10833 NN denotes presence
T6084 10821-10824 DT denotes the
T6083 10818-10820 IN denotes in
T6082 10809-10817 VBN denotes observed
T6081 10805-10808 VBD denotes was
T6080 10794-10804 NN denotes expression
T6079 10789-10793 NN denotes gene
T6078 10780-10788 NN denotes reporter
T6077 10768-10779 JJ denotes significant
T6076 10760-10767 IN denotes whereas
T6075 10758-10759 , denotes ,
T6074 10757-10758 -RRB- denotes )
T6073 10752-10757 NN denotes graph
T6072 10746-10751 JJ denotes right
T6071 10744-10745 , denotes ,
T6070 10742-10744 NNP denotes 1A
T6069 10735-10741 NN denotes figure
T6068 10733-10734 , denotes ,
T6067 10730-10733 NN denotes bar
T6066 10725-10729 JJ denotes grey
T6065 10724-10725 -LRB- denotes (
T6064 10713-10723 NN denotes activation
T6063 10704-10712 NN denotes promoter
T6062 10698-10703 JJ denotes IFNα4
T6061 10687-10697 JJ denotes negligible
T6060 10680-10686 VBD denotes showed
T6059 10666-10679 NN denotes co-expression
T6058 10661-10665 NNP denotes IRF7
T6057 10658-10660 IN denotes of
T6056 10650-10657 NN denotes absence
T6055 10646-10649 DT denotes the
T6054 10643-10645 IN denotes in
T6053 10632-10642 NN denotes expression
T6052 10630-10631 -RRB- denotes )
T6051 10625-10630 NNP denotes 2CARD
T6050 10624-10625 -LRB- denotes (
T6049 10618-10623 NNP denotes RIG-I
T6048 10616-10617 . denotes .
T6047 10607-10616 VBP denotes construct
T6046 10598-10606 NN denotes reporter
T6045 10587-10597 NN denotes luciferase
T6044 10581-10586 JJ denotes IFNα4
T6043 10567-10580 JJ denotes IRF7-specific
T6042 10564-10566 DT denotes an
T6041 10560-10563 CC denotes and
T6040 10556-10559 NNP denotes A20
T6039 10554-10555 , denotes ,
T6038 10553-10554 -RRB- denotes )
T6037 10548-10553 NNP denotes 2CARD
T6036 10547-10548 -LRB- denotes (
T6035 10541-10546 NNP denotes RIG-I
T6034 10532-10540 VBG denotes encoding
T6033 10523-10531 NNS denotes plasmids
T6032 10518-10522 IN denotes with
T6031 10509-10517 RB denotes together
T6030 10501-10508 NN denotes plasmid
T6029 10490-10500 NN denotes expression
T6028 10485-10489 NNP denotes IRF7
T6027 10482-10484 DT denotes an
T6026 10479-10481 IN denotes of
T6025 10471-10478 NNS denotes amounts
T6024 10465-10470 JJ denotes minor
T6023 10453-10464 VBD denotes transfected
T6022 10443-10452 RB denotes therefore
T6021 10440-10442 PRP denotes we
T6020 10438-10439 , denotes ,
T6019 10428-10438 NN denotes activation
T6018 10423-10427 NNP denotes IRF7
T6017 10420-10422 IN denotes on
T6016 10416-10419 NNP denotes A20
T6015 10413-10415 IN denotes of
T6014 10406-10412 NN denotes effect
T6013 10402-10405 DT denotes the
T6012 10392-10401 VB denotes determine
T6011 10389-10391 TO denotes To
T6010 10387-10388 . denotes .
T6009 10386-10387 NNP denotes ]
T6008 10384-10386 CD denotes 55
T6007 10383-10384 NNP denotes [
T6006 10381-10382 , denotes ,
T6005 10380-10381 NNP denotes ]
T6004 10378-10380 CD denotes 54
T6003 10377-10378 NNP denotes [
T6002 10366-10376 NN denotes activation
T6001 10361-10365 JJ denotes IRF3
T6000 10347-10360 JJ denotes virus-induced
T5999 10342-10346 IN denotes upon
T5998 10330-10341 VBN denotes upregulated
T5997 10322-10329 RB denotes rapidly
T5996 10318-10321 VBP denotes are
T5995 10311-10317 NNS denotes levels
T5994 10303-10310 NN denotes protein
T5993 10298-10302 NNP denotes IRF7
T5992 10294-10297 CC denotes and
T5991 10283-10293 NNS denotes conditions
T5990 10277-10282 NN denotes naïve
T5989 10271-10276 IN denotes under
T5988 10261-10270 VBN denotes expressed
T5987 10254-10260 RB denotes weakly
T5986 10251-10253 CC denotes or
T5985 10247-10250 RB denotes not
T5984 10244-10246 VBZ denotes is
T5983 10239-10243 NNP denotes IRF7
T5982 10237-10238 , denotes ,
T5981 10233-10237 NNP denotes IRF3
T5980 10226-10232 IN denotes Unlike
T5979 10224-10225 . denotes .
T5978 10214-10224 NN denotes activation
T5977 10209-10213 NNP denotes IRF7
T5976 10200-10208 VBZ denotes inhibits
T5975 10195-10199 RB denotes also
T5974 10191-10194 NNP denotes A20
T5973 10183-10190 IN denotes whether
T5972 10170-10182 VBD denotes investigated
T5971 10165-10169 JJ denotes next
T5970 10162-10164 PRP denotes We
T5969 10160-10161 . denotes .
T5968 10159-10160 -RRB- denotes )
T5967 10154-10159 NN denotes graph
T5966 10147-10153 JJ denotes middle
T5965 10143-10146 CC denotes and
T5964 10138-10142 VBD denotes left
T5963 10136-10137 , denotes ,
T5962 10134-10136 NNP denotes 1A
T5961 10127-10133 NN denotes figure
T5960 10126-10127 -LRB- denotes (
T5959 10124-10125 NNP denotes ]
T5958 10123-10124 -RRB- denotes )
T5957 10118-10123 NNP denotes 2CARD
T5956 10117-10118 -LRB- denotes (
T5955 10111-10116 NNP denotes RIG-I
T5954 10110-10111 NNP denotes [
T5953 10104-10109 NNP denotes RIG-I
T5952 10101-10103 IN denotes of
T5951 10093-10100 NNS denotes domains
T5950 10088-10092 NNP denotes CARD
T5949 10077-10087 JJ denotes N-terminal
T5948 10073-10076 CD denotes two
T5947 10069-10072 DT denotes the
T5946 10064-10068 RB denotes only
T5945 10061-10063 TO denotes to
T5944 10047-10060 JJ denotes corresponding
T5943 10045-10046 , denotes ,
T5942 10044-10045 NNP denotes ]
T5941 10042-10044 CD denotes 53
T5940 10041-10042 NNP denotes [
T5939 10035-10040 NNP denotes RIG-I
T5938 10032-10034 IN denotes of
T5937 10027-10031 NN denotes form
T5850 9456-9469 JJ denotes RIG-I-induced
T5849 9447-9455 NNS denotes inhibits
T5848 9443-9446 CD denotes A20
T6153 12611-12620 JJ denotes deficient
T5936 10020-10026 JJ denotes active
T5935 10007-10019 JJ denotes constitutive
T5934 9997-10006 VBN denotes truncated
T5933 9995-9996 DT denotes a
T5932 9992-9994 IN denotes of
T5931 9979-9991 NN denotes transfection
T5930 9976-9978 IN denotes by
T5929 9968-9975 VBN denotes induced
T5928 9957-9967 NN denotes activation
T5927 9952-9956 NN denotes gene
T5926 9943-9951 NN denotes reporter
T5925 9932-9942 NN denotes luciferase
T5924 9917-9931 JJ denotes IRF3-dependent
T5923 9913-9916 CC denotes and
T5922 9911-9912 : denotes -
T5921 9906-9911 NNP denotes NF-κB
T5920 9897-9905 VBZ denotes prevents
T5919 9891-9896 NNS denotes cells
T5918 9883-9890 CD denotes HEK293T
T5917 9880-9882 IN denotes in
T5916 9865-9879 NN denotes overexpression
T5915 9861-9864 CD denotes A20
T5914 9856-9860 IN denotes that
T5913 9851-9855 VBP denotes show
T5912 9848-9850 PRP denotes we
T5911 9846-9847 , denotes ,
T5910 9837-9846 RB denotes Similarly
T5909 9835-9836 . denotes .
T5908 9834-9835 NNP denotes ]
T5907 9832-9834 CD denotes 52
T5906 9831-9832 NNP denotes [
T5905 9829-9830 NNP denotes ]
T5904 9827-9829 CD denotes 50
T5903 9826-9827 NNP denotes [
T5902 9814-9825 NN denotes stimulation
T5901 9808-9813 NNP denotes RIG-I
T5900 9803-9807 IN denotes upon
T5899 9792-9802 NN denotes activation
T5898 9787-9791 NNP denotes IRF3
T5897 9783-9786 CC denotes and
T5896 9777-9782 NNP denotes NF-κB
T5895 9767-9776 VBZ denotes regulates
T5894 9756-9766 RB denotes negatively
T5875 9630-9639 NNS denotes cytokines
T5874 9614-9629 JJ denotes proinflammatory
T5873 9611-9613 IN denotes of
T5872 9600-9610 NN denotes expression
T5871 9596-9599 DT denotes the
T5870 9588-9595 VBP denotes promote
T5869 9582-9587 WDT denotes which
T5868 9580-9581 , denotes ,
T5867 9573-9580 NNS denotes factors
T5866 9559-9572 NN denotes transcription
T5865 9554-9558 NNP denotes IRF7
T5864 9550-9553 CC denotes and
T5863 9545-9549 NNP denotes IRF3
T5862 9543-9544 , denotes ,
T5861 9538-9543 NNP denotes NF-κB
T5860 9535-9537 IN denotes of
T5859 9524-9534 NN denotes activation
T5858 9520-9523 DT denotes the
T5857 9512-9519 VBZ denotes induces
T5856 9502-9511 VBG denotes signaling
T5855 9496-9501 NNP denotes RIG-I
T5854 9485-9495 NN denotes activation
T5853 9480-9484 JJ denotes IRF3
T5852 9476-9479 CC denotes and
T5851 9470-9475 NN denotes NF-κB
T5893 9752-9755 NNP denotes A20
T5892 9742-9751 VBN denotes expressed
T5891 9730-9741 RB denotes ectopically
T5890 9725-9729 IN denotes that
T5889 9719-9724 VBN denotes shown
T5888 9714-9718 VBP denotes have
T5887 9706-9713 NNS denotes studies
T5886 9697-9705 JJ denotes Previous
T5885 9695-9696 . denotes .
T5884 9684-9695 NN denotes propagation
T5883 9678-9683 JJ denotes viral
T5882 9670-9677 JJ denotes further
T5881 9661-9669 VB denotes restrict
T5880 9656-9660 IN denotes that
T5879 9651-9655 VBZ denotes IFNs
T5878 9649-9650 PRP denotes I
T5877 9644-9648 NN denotes type
T5876 9640-9643 CC denotes and
T3612 9205-9210 NNS denotes cells
T3611 9198-9204 JJ denotes immune
T3610 9191-9197 NN denotes innate
T3609 9188-9190 IN denotes of
T3608 9176-9187 NN denotes recruitment
T3607 9166-9175 JJ denotes augmented
T3606 9164-9165 , denotes ,
T3605 9154-9164 NN denotes production
T3604 9144-9153 NN denotes chemokine
T3603 9140-9143 CC denotes and
T3602 9131-9139 NN denotes cytokine
T3601 9121-9130 VBN denotes increased
T3600 9116-9120 IN denotes with
T3599 9105-9115 VBN denotes associated
T3598 9102-9104 VBZ denotes is
T3597 9097-9101 NNS denotes mice
T3596 9086-9096 NNP denotes A20myel-KO
T3595 9083-9085 IN denotes in
T3594 9079-9082 NNP denotes IAV
T3593 9071-9078 IN denotes against
T3592 9060-9070 NN denotes Protection
T3591 9058-9059 . denotes .
T3590 9054-9058 NNS denotes mice
T3589 9049-9053 NN denotes type
T3588 9044-9048 JJ denotes wild
T3587 9041-9043 TO denotes to
T3586 9032-9040 VBN denotes compared
T3585 9022-9031 NN denotes infection
T3584 9017-9021 NN denotes lung
T3583 9013-9016 NNP denotes IAV
T3582 9010-9012 TO denotes to
T3581 9001-9009 NN denotes response
T3580 8998-9000 IN denotes in
T3579 8988-8997 NN denotes morbidity
T3578 8980-8987 VBD denotes reduced
T3577 8976-8979 CC denotes and
T3576 8967-8975 NN denotes survival
T3575 8958-8966 JJ denotes enhanced
T3574 8953-8957 VBP denotes show
T3573 8948-8952 NNS denotes mice
T3572 8937-8947 JJ denotes A20myel-KO
T3571 8935-8936 , denotes ,
T3570 8922-8935 RB denotes Interestingly
T3569 8920-8921 . denotes .
T3568 8909-8920 NNS denotes macrophages
T3567 8906-8908 IN denotes in
T3566 8896-8905 VBG denotes signaling
T3565 8886-8895 JJ denotes antiviral
T3564 8882-8885 CC denotes and
T3563 8866-8881 JJ denotes proinflammatory
T3562 8854-8865 JJ denotes IAV-induced
T3561 8851-8853 IN denotes of
T3560 8841-8850 NN denotes regulator
T3559 8832-8840 JJ denotes negative
T3558 8824-8831 JJ denotes crucial
T3557 8822-8823 DT denotes a
T3556 8819-8821 VBZ denotes is
T3555 8815-8818 NNP denotes A20
T3554 8810-8814 IN denotes that
T3553 8801-8809 NN denotes evidence
T3552 8793-8800 VBP denotes provide
T3551 8788-8792 RB denotes here
T3550 8785-8787 PRP denotes we
T3549 8783-8784 , denotes ,
T3548 8779-8783 NNS denotes mice
T3547 8773-8778 DT denotes these
T3546 8770-8772 IN denotes of
T3545 8762-8769 VBN denotes derived
T3544 8756-8761 NNS denotes cells
T3543 8748-8755 JJ denotes primary
T3542 8744-8747 CC denotes and
T3541 8740-8743 NN denotes lab
T3490 8485-8486 : denotes -
T3489 8480-8485 NNP denotes RIG-I
T3488 8471-8479 VB denotes regulate
T3487 8467-8470 MD denotes may
T3486 8463-8466 NNP denotes A20
T3485 8458-8462 IN denotes that
T3484 8447-8457 VBG denotes indicating
T3483 8445-8446 , denotes ,
T3482 8440-8445 NNS denotes lines
T3481 8435-8439 NN denotes cell
T3480 8426-8434 JJ denotes specific
T3479 8423-8425 IN denotes in
T3478 8413-8422 VBG denotes silencing
T3477 8410-8412 CC denotes or
T3476 8395-8409 NN denotes overexpression
T3475 8389-8394 VBG denotes using
T3474 8381-8388 NNS denotes studies
T3473 8375-8380 NN denotes vitro
T3472 8372-8374 IN denotes in
T3471 8369-8371 IN denotes of
T3470 8362-8368 NN denotes number
T3469 8360-8361 DT denotes a
T3468 8357-8359 TO denotes to
T3467 8349-8356 VBN denotes limited
T3466 8345-8348 CC denotes and
T3465 8335-8344 VBN denotes described
T3464 8330-8334 RB denotes well
T3463 8325-8329 RBR denotes less
T3462 8322-8324 VBZ denotes is
T3461 8312-8321 NNS denotes responses
T3460 8305-8311 JJ denotes immune
T3459 8295-8304 JJ denotes antiviral
T3458 8292-8294 IN denotes of
T3457 8281-8291 NN denotes regulation
T3456 8277-8280 DT denotes the
T3455 8274-8276 IN denotes in
T3454 8270-8273 NNP denotes A20
T3453 8267-8269 IN denotes of
T3452 8262-8266 NN denotes role
T3451 8258-8261 DT denotes the
T3450 8256-8257 , denotes ,
T3449 8247-8256 NNS denotes responses
T3448 8231-8246 JJ denotes proinflammatory
T3447 8228-8230 IN denotes of
T3446 8217-8227 NN denotes regulation
T3445 8213-8216 DT denotes the
T3444 8210-8212 IN denotes in
T3443 8201-8209 NN denotes function
T3442 8189-8200 VBN denotes established
T3441 8184-8188 RB denotes well
T3440 8180-8183 PRP$ denotes its
T3439 8177-8179 TO denotes to
T3438 8168-8176 NN denotes contrast
T3437 8165-8167 IN denotes In
T3436 8163-8164 . denotes .
T3435 8162-8163 NNP denotes ]
T3434 8160-8162 CD denotes 45
T3433 8159-8160 NNP denotes [
T3432 8146-8158 NN denotes inflammation
T3431 8138-8145 JJ denotes chronic
T3430 8134-8137 CC denotes and
T3429 8125-8133 NNS denotes diseases
T3428 8114-8124 JJ denotes autoimmune
T3427 8106-8113 JJ denotes several
T3426 8101-8105 IN denotes with
T3425 8090-8100 VBN denotes associated
T3424 8086-8089 VBP denotes are
T3423 8081-8085 WDT denotes that
T3422 8075-8080 NN denotes locus
T3421 8071-8074 NNP denotes A20
T3420 8067-8070 DT denotes the
T3419 8064-8066 IN denotes in
T3418 8050-8063 NNS denotes polymorphisms
T3417 8047-8049 IN denotes of
T3416 8032-8046 NN denotes identification
T3415 8028-8031 DT denotes the
T3414 8020-8027 IN denotes through
T3413 8008-8019 VBN denotes illustrated
T3412 8003-8007 VBN denotes been
T3411 7994-8002 RB denotes recently
T3410 7990-7993 VBZ denotes has
T3409 7982-7989 NN denotes disease
T3408 7976-7981 JJ denotes human
T3407 7972-7975 IN denotes for
T3406 7963-7971 NNS denotes findings
T3405 7957-7962 DT denotes these
T3404 7954-7956 IN denotes of
T3403 7944-7953 NN denotes relevance
T3402 7940-7943 DT denotes The
T3401 7938-7939 . denotes .
T3400 7930-7938 NN denotes response
T3399 7917-7929 JJ denotes inflammatory
T3398 7913-7916 DT denotes the
T3397 7910-7912 IN denotes on
T3396 7904-7909 NN denotes brake
T3395 7894-7903 JJ denotes important
T3394 7891-7893 DT denotes an
T3393 7888-7890 VBZ denotes is
T3392 7884-7887 NNP denotes A20
T3391 7879-7883 IN denotes that
T3390 7866-7878 VBG denotes illustrating
T3389 7858-7865 JJ denotes further
T3388 7856-7857 , denotes ,
T3387 7855-7856 NNP denotes ]
T3386 7853-7855 CD denotes 48
T3385 7852-7853 NNP denotes [
T3384 7850-7851 NNP denotes ]
T3383 7848-7850 CD denotes 42
T3382 7847-7848 NNP denotes [
T3381 7834-7846 NN denotes inflammation
T3380 7826-7833 JJ denotes chronic
T3379 7822-7825 CC denotes and
T3378 7809-7821 NN denotes autoimmunity
T3377 7804-7808 IN denotes with
T3376 7793-7803 VBN denotes associated
T3375 7790-7792 VB denotes be
T3374 7787-7789 TO denotes to
T3373 7781-7786 VBN denotes shown
T3372 7777-7780 VBD denotes was
T3371 7771-7776 NNS denotes types
T3370 7766-7770 NN denotes cell
T3369 7757-7765 JJ denotes specific
T3368 7754-7756 IN denotes in
T3367 7750-7753 NNP denotes A20
T3366 7747-7749 IN denotes of
T3365 7737-7746 VBG denotes targeting
T3364 7732-7736 NN denotes gene
T3363 7730-7731 , denotes ,
T3362 7722-7730 RB denotes recently
T3361 7717-7721 RBR denotes More
T3360 7715-7716 . denotes .
T3359 7714-7715 NNP denotes ]
T3358 7712-7714 CD denotes 37
T3357 7711-7712 NNP denotes [
T3356 7702-7710 NN denotes cachexia
T3355 7698-7701 CC denotes and
T3354 7685-7697 NN denotes inflammation
T3353 7673-7684 JJ denotes multi-organ
T3352 7666-7672 JJ denotes severe
T3351 7663-7665 TO denotes to
T3350 7659-7662 JJ denotes due
T3349 7653-7658 NN denotes birth
T3348 7647-7652 IN denotes after
T3347 7641-7646 RB denotes early
T3346 7637-7640 VBP denotes die
T3345 7632-7636 NNS denotes mice
T3344 7622-7631 JJ denotes deficient
T3343 7618-7621 CD denotes A20
T3342 7613-7617 IN denotes that
T3341 7608-7612 NN denotes fact
T3340 7604-7607 DT denotes the
T3339 7601-7603 IN denotes by
T3338 7588-7600 VBN denotes demonstrated
T3337 7580-7587 RB denotes clearly
T3336 7577-7579 VBZ denotes is
T3335 7573-7576 NNP denotes A20
T3334 7570-7572 IN denotes of
T3333 7565-7569 NN denotes role
T3332 7547-7564 JJ denotes anti-inflammatory
T3331 7543-7546 DT denotes The
T3330 7541-7542 . denotes .
T3329 7540-7541 NNP denotes ]
T3328 7538-7540 CD denotes 41
T3327 7537-7538 NNP denotes [
T3326 7531-7536 NNP denotes IL-1R
T3325 7527-7530 CC denotes and
T3324 7525-7526 , denotes ,
T3323 7524-7525 NNP denotes ]
T3322 7522-7524 CD denotes 40
T3321 7521-7522 NNP denotes [
T3320 7516-7520 CD denotes TLR4
T3319 7514-7515 , denotes ,
T3318 7513-7514 NNP denotes ]
T3317 7511-7513 CD denotes 39
T3316 7510-7511 NNP denotes [
T3315 7508-7509 NNP denotes ]
T3314 7506-7508 CD denotes 37
T3313 7505-7506 VBP denotes [
T3312 7503-7504 PRP denotes I
T3311 7494-7502 NN denotes receptor
T3310 7490-7493 NNP denotes TNF
T3309 7487-7489 IN denotes as
T3308 7482-7486 JJ denotes such
T3307 7472-7481 NNS denotes receptors
T3306 7463-7471 JJ denotes multiple
T3305 7460-7462 TO denotes to
T3304 7451-7459 NN denotes response
T3303 7448-7450 IN denotes in
T3302 7444-7447 NNP denotes A20
T3301 7441-7443 IN denotes by
T3300 7431-7440 VBG denotes signaling
T3299 7415-7430 JJ denotes proinflammatory
T3298 7412-7414 IN denotes of
T3297 7401-7411 NN denotes regulation
T3296 7392-7400 JJ denotes negative
T3295 7388-7391 DT denotes the
T3294 7385-7387 IN denotes in
T3293 7376-7384 VBN denotes involved
T3292 7373-7375 VB denotes be
T3291 7370-7372 TO denotes to
T3290 7364-7369 VBN denotes shown
T3289 7353-7363 RB denotes previously
T3288 7348-7352 VBD denotes were
T3287 7337-7347 NNS denotes mechanisms
T3286 7324-7336 JJ denotes noncatalytic
T3285 7320-7323 CC denotes and
T3284 7310-7319 JJ denotes catalytic
T3283 7305-7309 DT denotes Both
T3282 7303-7304 . denotes .
T3281 7295-7303 NN denotes activity
T3280 7288-7294 NN denotes ligase
T3279 7278-7287 NN denotes ubiquitin
T3278 7275-7277 NN denotes E3
T3277 7262-7274 JJ denotes K48-specific
T3276 7252-7261 JJ denotes dependent
T3275 7245-7251 NN denotes finger
T3063 6144-6156 NN denotes transduction
T3062 6137-6143 NN denotes signal
T3061 6128-6136 VBD denotes mediated
T3060 6122-6127 NNP denotes RIG-I
T3059 6113-6121 VB denotes regulate
T3058 6102-6112 RB denotes negatively
T3057 6098-6101 CC denotes and
T3056 6087-6097 RB denotes positively
T3055 6082-6086 DT denotes both
T3054 6076-6081 WDT denotes which
T3053 6074-6075 , denotes ,
T3052 6067-6074 NNS denotes enzymes
T3051 6057-6066 VBG denotes modifying
T3050 6047-6056 NN denotes ubiquitin
T3049 6039-6046 JJ denotes various
T3048 6036-6038 IN denotes of
T3047 6029-6035 NN denotes action
T3046 6025-6028 DT denotes the
T3045 6016-6024 VBZ denotes requires
T3044 6011-6015 NNP denotes MAVS
T3043 6008-6010 IN denotes of
T3042 5997-6007 JJ denotes downstream
T3041 5987-5996 VBG denotes Signaling
T3040 5985-5986 . denotes .
T3039 5984-5985 NNP denotes ]
T3038 5982-5984 CD denotes 20
T3037 5981-5982 NNP denotes [
T3036 5979-5980 NNP denotes ]
T3035 5977-5979 CD denotes 17
T3034 5976-5977 NNP denotes [
T3033 5969-5975 NN denotes domain
T3032 5955-5968 NN denotes transmembrane
T3031 5944-5954 JJ denotes C-terminal
T3030 5940-5943 PRP$ denotes its
T3029 5936-5939 IN denotes via
T3028 5927-5935 NN denotes membrane
T3027 5913-5926 JJ denotes mitochondrial
T3026 5907-5912 JJ denotes outer
T3025 5903-5906 DT denotes the
T3024 5900-5902 IN denotes in
T3023 5892-5899 NNS denotes inserts
T3022 5888-5891 CC denotes and
T3021 5885-5887 TO denotes to
T3020 5872-5884 VBZ denotes translocates
T3019 5859-5871 RB denotes subsequently
T3018 5853-5858 WDT denotes which
T3017 5851-5852 , denotes ,
T3016 5844-5851 NN denotes protein
T3015 5836-5843 NN denotes adaptor
T3014 5834-5835 -RRB- denotes )
T3013 5828-5834 NNP denotes Cardif
T3012 5826-5827 , denotes ,
T3011 5822-5826 NNP denotes VISA
T3010 5820-5821 , denotes ,
T3009 5815-5820 NNP denotes IPS-1
T3008 5808-5814 VBN denotes termed
T3007 5803-5807 RB denotes also
T3006 5802-5803 -LRB- denotes (
T3005 5797-5801 NNP denotes MAVS
T3004 5793-5796 DT denotes the
T3003 5790-5792 IN denotes of
T3002 5783-5789 NN denotes domain
T3001 5778-5782 NNP denotes CARD
T3000 5774-5777 DT denotes the
T2999 5769-5773 IN denotes with
T2998 5759-5768 NN denotes associate
T2997 5753-5758 NNP denotes RIG-I
T2996 5750-5752 IN denotes of
T2995 5742-5749 NNS denotes domains
T2994 5737-5741 NNP denotes CARD
T2993 5733-5736 DT denotes the
T2992 5731-5732 , denotes ,
T2991 5724-5731 JJ denotes binding
T2990 5717-5723 JJ denotes ligand
T2989 5712-5716 IN denotes Upon
T2988 5710-5711 . denotes .
T2987 5703-5710 NNS denotes domains
T2986 5698-5702 NNP denotes CARD
T2985 5687-5697 JJ denotes N-terminal
T2984 5683-5686 CD denotes two
T2983 5679-5682 CC denotes and
T2982 5677-5678 , denotes ,
T2981 5666-5677 NN denotes recognition
T2980 5659-5665 NN denotes ligand
T2979 5655-5658 IN denotes for
T2978 5646-5654 VBN denotes required
T2977 5643-5645 VBZ denotes is
T2976 5637-5642 WDT denotes which
T2975 5635-5636 , denotes ,
T2974 5629-5635 NN denotes domain
T2973 5620-5628 NN denotes helicase
T2972 5616-5619 NN denotes box
T2971 5609-5615 NNP denotes DExD/H
T2970 5598-5608 JJ denotes C-terminal
T2969 5596-5597 DT denotes a
T2968 5587-5595 VBZ denotes contains
T2967 5581-5586 NNP denotes RIG-I
T2966 5579-5580 . denotes .
T2965 5570-5579 NN denotes influenza
T2964 5567-5569 IN denotes of
T2963 5554-5566 NN denotes pathogenesis
T2962 5550-5553 DT denotes the
T2961 5547-5549 TO denotes to
T2960 5536-5546 VB denotes contribute
T2959 5533-5535 TO denotes to
T2958 5526-5532 JJ denotes likely
T2957 5523-5525 VBZ denotes is
T2956 5517-5522 NNS denotes cells
T2955 5510-5516 JJ denotes immune
T2954 5507-5509 IN denotes by
T2953 5498-5506 VBN denotes released
T2952 5488-5497 NNS denotes mediators
T2951 5485-5487 IN denotes of
T2950 5477-5484 NNS denotes effects
T2949 5469-5476 JJ denotes harmful
T2948 5465-5468 CC denotes and
T2947 5454-5464 JJ denotes beneficial
T2946 5450-5453 DT denotes the
T2945 5442-5449 IN denotes between
T2944 5432-5441 NN denotes imbalance
T2943 5429-5431 DT denotes an
T2942 5424-5428 IN denotes that
T2941 5415-5423 VBP denotes indicate
T2940 5407-5414 NNS denotes results
T2939 5401-5406 DT denotes These
T2938 5399-5400 . denotes .
T2937 5398-5399 NNP denotes ]
T2936 5396-5398 CD denotes 16
T2935 5395-5396 NNP denotes [
T2934 5385-5394 NN denotes infection
T2933 5379-5384 JJ denotes acute
T2932 5376-5378 TO denotes to
T2931 5366-5375 NN denotes advantage
T2930 5357-5365 NN denotes survival
T2929 5355-5356 DT denotes a
T2928 5350-5354 VBP denotes have
T2927 5345-5349 NNS denotes mice
T2926 5335-5344 JJ denotes deficient
T2925 5330-5334 CD denotes TLR3
T2924 5322-5329 IN denotes whereas
T2923 5320-5321 , denotes ,
T2922 5319-5320 NNP denotes ]
T2921 5317-5319 CD denotes 15
T2920 5316-5317 NNP denotes [
T2919 5314-5315 , denotes ,
T2918 5313-5314 NNP denotes ]
T2917 5311-5313 CD denotes 14
T2916 5310-5311 NNP denotes [
T2915 5306-5309 NNP denotes IAV
T2914 5303-5305 TO denotes to
T2913 5291-5302 JJ denotes susceptible
T2912 5284-5290 RB denotes highly
T2911 5280-5283 VBP denotes are
T2910 5275-5279 NNS denotes mice
T2909 5265-5274 NN denotes deficient
T2908 5259-5264 NNP denotes RIG-I
T2907 5257-5258 , denotes ,
T2906 5244-5257 RB denotes Interestingly
T2905 5242-5243 . denotes .
T2904 5241-5242 NNP denotes ]
T2903 5239-5241 CD denotes 13
T2902 5238-5239 NNP denotes [
T2901 5228-5237 VBG denotes signaling
T2900 5219-5227 VBD denotes mediated
T2899 5213-5218 NNP denotes RIG-I
T2898 5210-5212 IN denotes on
T2897 5202-5209 VBZ denotes depends
T2896 5194-5201 RB denotes largely
T2895 5185-5193 NN denotes response
T2894 5178-5184 JJ denotes immune
T2893 5168-5177 JJ denotes antiviral
T2892 5161-5167 NN denotes innate
T2891 5157-5160 DT denotes the
T2890 5154-5156 IN denotes of
T2889 5143-5153 NN denotes initiation
T2888 5139-5142 DT denotes the
T2887 5135-5138 CC denotes but
T2886 5133-5134 , denotes ,
T2885 5130-5133 NNP denotes IAV
T2884 5127-5129 TO denotes to
T2883 5118-5126 NN denotes response
T2882 5102-5117 JJ denotes proinflammatory
T2881 5098-5101 DT denotes the
T2880 5095-5097 TO denotes to
T2879 5084-5094 VBP denotes contribute
T2878 5074-5083 NNS denotes receptors
T2877 5069-5073 DT denotes Both
T2876 5067-5068 . denotes .
T2875 5066-5067 NNP denotes ]
T2874 5064-5066 CD denotes 12
T3540 8736-8739 PRP$ denotes our
T3539 8733-8735 IN denotes in
T3538 8723-8732 VBN denotes generated
T3537 8714-8722 RB denotes recently
T3536 8709-8713 VBD denotes were
T3535 8704-8708 WDT denotes that
T3534 8702-8703 -RRB- denotes )
T3533 8692-8702 JJ denotes A20myel-KO
T3532 8691-8692 -LRB- denotes (
T3531 8686-8690 NNS denotes mice
T3530 8677-8685 NN denotes knockout
T3529 8673-8676 NNP denotes A20
T3528 8664-8672 JJ denotes specific
T3527 8659-8663 NN denotes cell
T3526 8651-8658 JJ denotes myeloid
T3525 8645-8650 VBG denotes Using
T3524 8643-8644 . denotes .
T3523 8634-8643 VBN denotes clarified
T3522 8631-8633 VB denotes be
T3521 8628-8630 TO denotes to
T3520 8620-8627 VBZ denotes remains
T3519 8610-8619 NN denotes infection
T3518 8604-8609 JJ denotes viral
T3517 8601-8603 TO denotes to
T3516 8592-8600 NN denotes response
T3515 8588-8591 DT denotes the
T3514 8585-8587 IN denotes in
T3513 8581-8584 NNP denotes A20
T3512 8578-8580 IN denotes of
T3511 8573-8577 NN denotes role
T3510 8568-8572 NN denotes vivo
T3509 8565-8567 IN denotes in
T3508 8557-8564 JJ denotes precise
T3507 8553-8556 DT denotes the
T3506 8551-8552 , denotes ,
T3505 8544-8551 RB denotes However
T3504 8542-8543 . denotes .
T3503 8541-8542 NNP denotes ]
T3502 8539-8541 CD denotes 52
T3501 8538-8539 NNP denotes [
T3500 8536-8537 NNP denotes ]
T3499 8534-8536 CD denotes 49
T3498 8533-8534 NNP denotes [
T3497 8527-8532 NNP denotes IRF-3
T3496 8523-8526 CC denotes and
T3495 8517-8522 NNP denotes NF-κB
T3494 8514-8516 TO denotes to
T3493 8504-8513 VBG denotes signaling
T3492 8491-8503 JJ denotes TLR3-induced
T3491 8487-8490 CC denotes and
T2873 5063-5064 NNP denotes [
T2872 5061-5062 NNP denotes ]
T2871 5059-5061 CD denotes 10
T2870 5058-5059 NNP denotes [
T2869 5048-5057 NN denotes infection
T2868 5044-5047 NNP denotes IAV
T2867 5041-5043 IN denotes of
T2866 5033-5040 NNS denotes sensors
T2865 5030-5032 IN denotes as
T2864 5019-5029 VBN denotes implicated
T2863 5014-5018 VBN denotes been
T2862 5009-5013 VBP denotes have
T2861 5003-5008 NNP denotes RIG-I
T2860 4999-5002 CC denotes and
T2859 4994-4998 CD denotes TLR3
T2858 4992-4993 . denotes .
T2857 4981-4992 NN denotes replication
T2856 4975-4980 JJ denotes viral
T2855 4972-4974 IN denotes of
T2854 4959-4971 JJ denotes intermediate
T2853 4956-4958 DT denotes an
T2852 4950-4955 VBG denotes being
T2851 4943-4949 JJ denotes latter
T2850 4939-4942 DT denotes the
T2849 4937-4938 , denotes ,
T2848 4934-4937 NNP denotes RNA
T2720 4162-4171 JJ denotes dendritic
T2719 4149-4161 JJ denotes plasmacytoid
T2718 4139-4148 VBG denotes producing
T2717 4135-4138 VBP denotes IFN
T2716 4133-4134 PRP denotes I
T2715 4128-4132 NN denotes type
T2714 4116-4127 VBN denotes specialized
T2713 4113-4115 TO denotes to
T2712 4102-4112 VBN denotes restricted
T2711 4098-4101 VBP denotes are
T2710 4088-4097 NNS denotes responses
T2709 4078-4087 JJ denotes antiviral
T2708 4069-4077 VBD denotes mediated
T2707 4065-4068 NNP denotes TLR
T2706 4063-4064 . denotes .
T2705 4062-4063 NNP denotes ]
T2704 4061-4062 CD denotes 8
T2703 4060-4061 NNP denotes [
T2702 4054-4059 NNP denotes IFI16
T2701 4050-4053 CC denotes and
T2700 4048-4049 NNP denotes ]
T2699 4047-4048 CD denotes 7
T2698 4046-4047 NNP denotes [
T2697 4044-4045 , denotes ,
T2696 4043-4044 NNP denotes ]
T2695 4042-4043 CD denotes 6
T2694 4041-4042 NNP denotes [
T2693 4039-4040 , denotes ,
T2692 4038-4039 NNP denotes ]
T2691 4037-4038 CD denotes 5
T2690 4036-4037 NNP denotes [
T2689 4031-4035 NNP denotes AIM2
T2688 4022-4030 NNS denotes proteins
T2687 4011-4021 VBG denotes containing
T2686 4004-4010 NN denotes domain
T2685 3998-4003 NNP denotes PYHIN
T2684 3994-3997 DT denotes the
T2683 3990-3993 CC denotes and
T2682 3988-3989 NNP denotes ]
T2681 3987-3988 CD denotes 4
T2680 3986-3987 NNP denotes [
T2679 3982-3985 NNP denotes DAI
T2678 3980-3981 , denotes ,
T2677 3976-3980 CD denotes TLR9
T2676 3968-3975 VBP denotes include
T2675 3960-3967 NNS denotes viruses
T2674 3956-3959 NNP denotes DNA
T2673 3953-3955 TO denotes to
T2672 3943-3952 NNS denotes responses
T2671 3936-3942 JJ denotes immune
T2670 3926-3935 JJ denotes antiviral
T2669 3918-3925 VBP denotes mediate
T2668 3913-3917 WDT denotes that
T2667 3905-3912 NNS denotes sensors
T2666 3901-3904 NNP denotes DNA
T2665 3887-3900 NNP denotes Intracellular
T2664 3885-3886 . denotes .
T2663 3884-3885 -RRB- denotes )
T2662 3880-3884 NNP denotes MDA5
T2661 3878-3879 , denotes ,
T2660 3873-3878 NNP denotes RIG-I
T2659 3871-3872 , denotes ,
T2658 3867-3871 CD denotes TLR3
T2657 3866-3867 -LRB- denotes (
T2656 3862-3865 NNP denotes RNA
T2655 3853-3861 VBD denotes stranded
T2654 3846-3852 JJ denotes double
T2653 3843-3845 CC denotes or
T2652 3841-3842 -RRB- denotes )
T2651 3837-3841 NNP denotes Nod2
T2650 3835-3836 , denotes ,
T2649 3831-3835 CD denotes TLR8
T2648 3829-3830 , denotes ,
T2647 3825-3829 CD denotes TLR7
T2646 3824-3825 -LRB- denotes (
T2645 3815-3823 VBN denotes stranded
T2644 3808-3814 JJ denotes single
T2643 3802-3807 JJ denotes viral
T2642 3799-3801 IN denotes of
T2641 3790-3798 NN denotes presence
T2640 3786-3789 DT denotes the
T2639 3779-3785 VBP denotes detect
T2638 3777-3778 -RRB- denotes )
T2637 3773-3777 NNS denotes NLRs
T2636 3772-3773 -LRB- denotes (
T2635 3762-3771 NNS denotes receptors
T2634 3753-3761 JJ denotes Nod-like
T2633 3750-3752 CC denotes or
T2632 3748-3749 -RRB- denotes )
T2631 3744-3748 NNS denotes RLRs
T2630 3743-3744 -LRB- denotes (
T2629 3733-3742 NNS denotes receptors
T2628 3722-3732 JJ denotes RIG-I-like
T2627 3713-3721 NN denotes helicase
T2626 3709-3712 NNP denotes RNA
T2625 3697-3708 JJ denotes cytoplasmic
T2624 3693-3696 CC denotes and
T2623 3691-3692 -RRB- denotes )
T2622 3687-3691 NNS denotes TLRs
T2621 3686-3687 -LRB- denotes (
T2620 3676-3685 NNS denotes receptors
T2619 3666-3675 JJ denotes Toll-like
T2618 3656-3665 NNP denotes Endosomal
T2617 3654-3655 . denotes .
T2616 3653-3654 NNP denotes ]
T2615 3652-3653 CD denotes 3
T2614 3651-3652 VBP denotes [
T2613 3646-3650 NNS denotes PRRs
T2612 3632-3645 JJ denotes intracellular
T2611 3623-3631 JJ denotes specific
T2610 3620-3622 IN denotes by
T2609 3613-3619 VBN denotes sensed
T2608 3610-3612 VB denotes be
T2607 3606-3609 MD denotes can
T2606 3604-3605 , denotes ,
T2605 3596-3604 NNS denotes products
T2604 3582-3595 NN denotes transcription
T2603 3576-3581 JJ denotes viral
T2602 3572-3575 CC denotes and
T2601 3558-3571 NNS denotes intermediates
T2600 3546-3557 NN denotes replication
T2599 3540-3545 JJ denotes viral
T2598 3538-3539 , denotes ,
T2597 3535-3538 NNP denotes DNA
T2596 3531-3534 CC denotes and
T2595 3527-3530 NNP denotes RNA
T2594 3521-3526 JJ denotes viral
T2593 3518-3520 IN denotes as
T2592 3513-3517 JJ denotes such
T2591 3511-3512 , denotes ,
T2590 3506-3511 NNS denotes acids
T2589 3498-3505 JJ denotes nucleic
T2588 3492-3497 JJ denotes viral
T2587 3489-3491 IN denotes of
T2586 3480-3488 NN denotes presence
T2585 3476-3479 DT denotes The
T2584 3474-3475 . denotes .
T2583 3473-3474 NNP denotes ]
T2582 3472-3473 CD denotes 2
T2581 3471-3472 NNP denotes [
T2580 3469-3470 , denotes ,
T2579 3468-3469 NNP denotes ]
T2578 3467-3468 CD denotes 1
T2577 3466-3467 NNP denotes [
T2576 3461-3465 NNP denotes IRF7
T2575 3457-3460 CC denotes and
T2574 3452-3456 NNP denotes IRF3
T2573 3450-3451 , denotes ,
T2572 3446-3450 NNP denotes AP-1
T2571 3444-3445 , denotes ,
T2570 3439-3444 NNP denotes NF-κB
T2569 3436-3438 IN denotes as
T2568 3431-3435 JJ denotes such
T2567 3423-3430 NNS denotes factors
T2566 3409-3422 NN denotes transcription
T2565 3401-3408 JJ denotes various
T2564 3393-3400 VBP denotes control
T2563 3388-3392 WDT denotes that
T2562 3379-3387 NNS denotes pathways
T2561 3369-3378 VBG denotes signaling
T2560 3358-3368 JJ denotes downstream
T2559 3355-3357 IN denotes of
T2558 3344-3354 NN denotes activation
T2557 3336-3343 IN denotes through
T2556 3334-3335 -RRB- denotes )
T2555 3329-3334 NNP denotes IFN-β
T2554 3325-3328 CC denotes and
T2553 3323-3324 -RRB- denotes )
T2552 3318-3323 JJ denotes IFN-α
T2551 3317-3318 -LRB- denotes (
T2550 3304-3316 JJ denotes interferon-α
T2549 3303-3304 -LRB- denotes (
T2548 3291-3302 VBZ denotes interferons
T2547 3289-3290 PRP denotes I
T2546 3284-3288 NN denotes type
T2545 3280-3283 CC denotes and
T2544 3278-3279 -RRB- denotes )
T2543 3274-3278 NNP denotes IL-1
T2542 3270-3273 CC denotes and
T2541 3265-3269 NNP denotes IL-6
T2540 3263-3264 , denotes ,
T2539 3260-3263 NNP denotes TNF
T2538 3255-3259 FW denotes e.g.
T2537 3254-3255 -LRB- denotes (
T2536 3244-3253 NNS denotes cytokines
T2535 3228-3243 JJ denotes proinflammatory
T2534 3223-3227 NN denotes host
T2533 3220-3222 IN denotes of
T2532 3209-3219 NN denotes production
T2531 3205-3208 DT denotes the
T3274 7240-7244 NN denotes zinc
T3273 7231-7239 JJ denotes atypical
T3272 7223-7230 VBZ denotes harbors
T3271 7218-7222 RB denotes also
T3270 7214-7217 NNP denotes A20
T3269 7212-7213 , denotes ,
T3268 7199-7212 RB denotes Interestingly
T3267 7197-7198 . denotes .
T3253 7106-7118 NN denotes transduction
T3252 7099-7105 NN denotes signal
T3251 7089-7098 JJ denotes antiviral
T3250 7081-7088 NNS denotes dampens
T3249 7073-7080 JJ denotes further
T3248 7071-7072 NNP denotes ]
T3247 7069-7071 CD denotes 36
T3246 7068-7069 NNP denotes [
T3245 7062-7067 NNP denotes RBCK1
T3244 7058-7061 CC denotes and
T3243 7056-7057 NNP denotes ]
T3242 7054-7056 CD denotes 35
T3241 7053-7054 NNP denotes [
T3240 7046-7052 CD denotes TRIM21
T3239 7044-7045 , denotes ,
T3238 7043-7044 NNP denotes ]
T3237 7041-7043 CD denotes 34
T3236 7040-7041 NNP denotes [
T3235 7035-7039 NNP denotes RAUL
T3234 7032-7034 IN denotes as
T3233 7027-7031 JJ denotes such
T3232 7023-7026 NNS denotes E3s
T3231 7020-7022 IN denotes by
T3230 7012-7019 NNS denotes factors
T3229 6998-7011 NN denotes transcription
T3228 6993-6997 NNP denotes IRF7
T3227 6989-6992 CC denotes and
T3226 6984-6988 NNP denotes IRF3
T3225 6980-6983 DT denotes the
T3224 6977-6979 TO denotes to
T3223 6970-6976 NNS denotes chains
T3222 6956-6969 NN denotes polyubiquitin
T3221 6943-6955 JJ denotes K48-specific
T3220 6940-6942 IN denotes of
T3219 6929-6939 NN denotes attachment
T3218 6925-6928 DT denotes the
T3217 6923-6924 , denotes ,
T3216 6911-6923 RB denotes Additionally
T3215 6909-6910 . denotes .
T3214 6900-6909 VBG denotes signaling
T3213 6889-6899 JJ denotes downstream
T3212 6881-6888 JJ denotes further
T3211 6870-6880 VBG denotes inhibiting
T3210 6865-6869 RB denotes thus
T3209 6863-6864 , denotes ,
T3208 6852-6863 NN denotes degradation
T3207 6843-6851 JJ denotes mediated
T3206 6832-6842 JJ denotes proteasome
T3205 6828-6831 IN denotes for
T3204 6822-6827 NNP denotes TRAF3
T3203 6818-6821 CC denotes and
T3202 6813-6817 NNP denotes MAVS
T3201 6800-6812 RB denotes respectively
T3200 6795-6799 NN denotes mark
T3199 6793-6794 NNP denotes ]
T3198 6791-6793 CD denotes 33
T3197 6790-6791 NNP denotes [
T3196 6782-6789 NNP denotes TRIAD3A
T3195 6778-6781 CC denotes and
T3194 6776-6777 NNP denotes ]
T3193 6774-6776 CD denotes 32
T3192 6773-6774 NNP denotes [
T3191 6768-6772 NNP denotes AIP4
T3190 6765-6767 IN denotes as
T3189 6760-6764 JJ denotes such
T3188 6758-6759 , denotes ,
T3187 6751-6758 NNS denotes ligases
T3186 6741-6750 NN denotes ubiquitin
T3185 6728-6740 JJ denotes K48-specific
T3184 6720-6727 JJ denotes various
T3183 6718-6719 , denotes ,
T3182 6707-6718 RB denotes Furthermore
T3181 6705-6706 . denotes .
T3180 6696-6705 NNS denotes molecules
T3179 6686-6695 VBG denotes signaling
T3178 6678-6685 JJ denotes several
T3177 6673-6677 IN denotes from
T3176 6666-6672 NNS denotes chains
T3175 6652-6665 NN denotes polyubiquitin
T3174 6641-6651 JJ denotes K63-linked
T3173 6632-6640 VBG denotes removing
T3172 6619-6631 RB denotes specifically
T3171 6616-6618 IN denotes by
T3170 6606-6615 VBG denotes signaling
T3169 6602-6605 NNP denotes RLR
T3168 6593-6601 VB denotes regulate
T3167 6582-6592 RB denotes negatively
T3166 6579-6581 TO denotes to
T3165 6573-6578 VBN denotes shown
T3164 6568-6572 VBN denotes been
T3163 6563-6567 VBP denotes have
T3162 6561-6562 NNP denotes ]
T3161 6559-6561 CD denotes 31
T3160 6558-6559 NNP denotes [
T3159 6550-6557 NNP denotes OTUB1/2
T3158 6546-6549 CC denotes and
T3157 6544-6545 NNP denotes ]
T3156 6542-6544 CD denotes 30
T3155 6541-6542 NNP denotes [
T3154 6539-6540 , denotes ,
T3153 6538-6539 NNP denotes ]
T3152 6536-6538 CD denotes 29
T3151 6535-6536 NNP denotes [
T3150 6530-6534 NNP denotes CYLD
T3149 6528-6529 , denotes ,
T3148 6527-6528 NNP denotes ]
T3147 6525-6527 CD denotes 28
T3146 6524-6525 NNP denotes [
T3145 6519-6523 NNP denotes DUBA
T3144 6516-6518 IN denotes as
T3143 6511-6515 JJ denotes such
T3142 6509-6510 , denotes ,
T3141 6508-6509 -RRB- denotes )
T3140 6504-6508 NNS denotes DUBs
T3139 6503-6504 -LRB- denotes (
T3138 6495-6502 NNS denotes enzymes
T3137 6478-6494 VBG denotes deubiquitinating
T3136 6476-6477 , denotes ,
T3135 6472-6476 NN denotes hand
T3134 6466-6471 JJ denotes other
T3133 6462-6465 DT denotes the
T3132 6459-6461 IN denotes On
T3131 6457-6458 . denotes .
T3130 6446-6457 NN denotes stimulation
T3129 6440-6445 NNP denotes RIG-I
T3128 6435-6439 IN denotes upon
T3127 6424-6434 NN denotes activation
T3126 6419-6423 JJ denotes IRF3
T3125 6415-6418 CC denotes and
T3124 6409-6414 JJ denotes NF-κB
T3123 6396-6408 RB denotes respectively
T3122 6388-6395 VB denotes mediate
T3121 6386-6387 NNP denotes ]
T3120 6384-6386 CD denotes 27
T3119 6383-6384 NNP denotes [
T3118 6377-6382 NNP denotes TRAF3
T3117 6373-6376 CC denotes and
T3116 6371-6372 NNP denotes ]
T3115 6369-6371 CD denotes 26
T3114 6368-6369 NNP denotes [
T3113 6366-6367 , denotes ,
T3112 6365-6366 NNP denotes ]
T3111 6363-6365 CD denotes 25
T3110 6362-6363 NNP denotes [
T3109 6356-6361 CD denotes TRAF6
T3108 6353-6355 IN denotes as
T3107 6348-6352 JJ denotes such
T3106 6340-6347 NNS denotes ligases
T3105 6330-6339 NN denotes ubiquitin
T3104 6316-6329 VBD denotes characterized
T3103 6311-6315 RB denotes well
T3102 6309-6310 , denotes ,
T3101 6301-6309 NN denotes addition
T3100 6298-6300 IN denotes In
T3099 6296-6297 . denotes .
T3098 6286-6296 NN denotes activation
T3097 6280-6285 NNP denotes RIG-I
T3096 6272-6279 VB denotes promote
T3095 6263-6271 RB denotes directly
T3094 6260-6262 TO denotes to
T3093 6254-6259 VBN denotes shown
T3092 6249-6253 VBN denotes been
T3091 6244-6248 VBP denotes have
T3090 6242-6243 , denotes ,
T3089 6241-6242 NNP denotes ]
T3088 6239-6241 CD denotes 24
T3087 6238-6239 NNP denotes [
T3086 6236-6237 , denotes ,
T3085 6235-6236 NNP denotes ]
T3084 6233-6235 CD denotes 23
T3083 6232-6233 NNP denotes [
T3082 6225-6231 NNP denotes Riplet
T3081 6221-6224 CC denotes and
T3080 6219-6220 NNP denotes ]
T3079 6217-6219 CD denotes 22
T3078 6216-6217 NNP denotes [
T3077 6209-6215 CD denotes TRIM25
T3076 6206-6208 IN denotes as
T3075 6201-6205 JJ denotes such
T3074 6199-6200 , denotes ,
T3073 6198-6199 -RRB- denotes )
T3072 6195-6198 NNS denotes E3s
T3071 6194-6195 -LRB- denotes (
T3070 6186-6193 NNS denotes ligases
T3069 6176-6185 NN denotes ubiquitin
T3068 6163-6175 JJ denotes K63-specific
T3067 6161-6162 . denotes .
T3066 6160-6161 NNP denotes ]
T3065 6158-6160 CD denotes 21
T3064 6157-6158 NNP denotes [
T2530 3197-3204 VBZ denotes induces
T2529 3192-3196 NNS denotes PRRs
T2528 3189-3191 IN denotes of
T2527 3178-3188 VBG denotes Triggering
T2526 3176-3177 . denotes .
T2525 3168-3176 NN denotes pathogen
T2524 3159-3167 VBG denotes invading
T2523 3155-3158 DT denotes the
T2522 3152-3154 IN denotes of
T2521 3141-3151 NNS denotes structures
T2520 3131-3140 JJ denotes molecular
T2519 3121-3130 JJ denotes conserved
T2518 3114-3120 VBP denotes detect
T2517 3108-3113 WDT denotes which
T2516 3106-3107 , denotes ,
T2515 3105-3106 -RRB- denotes )
T2514 3102-3105 NNP denotes PRR
T2513 3101-3102 -LRB- denotes (
T2512 3091-3100 NNS denotes receptors
T2511 3079-3090 NN denotes recognition
T2510 3071-3078 NN denotes pattern
T2509 3059-3070 VBN denotes specialized
T2508 3056-3058 IN denotes of
T2507 3049-3055 NN denotes action
T2506 3045-3048 DT denotes the
T2505 3036-3044 VBZ denotes involves
T3266 7193-7197 NNS denotes DUBs
T3265 7190-7192 IN denotes of
T3264 7183-7189 NN denotes family
T3263 7172-7182 NNP denotes OTU-domain
T3262 7168-7171 DT denotes the
T3261 7165-7167 TO denotes to
T3260 7155-7164 VBG denotes belonging
T3259 7148-7154 NN denotes enzyme
T3258 7130-7147 JJ denotes ubiquitin-editing
T3257 7127-7129 DT denotes an
T3256 7124-7126 VBZ denotes is
T3255 7120-7123 CD denotes A20
T3254 7118-7119 . denotes .
T2847 4925-4933 VBD denotes stranded
T2846 4918-4924 JJ denotes double
T2845 4914-4917 CC denotes and
T2844 4910-4913 NNP denotes RNA
T2843 4902-4909 JJ denotes genomic
T2842 4886-4901 JJ denotes single-stranded
T2841 4883-4885 IN denotes of
T2840 4878-4882 NN denotes cell
T2839 4873-4877 NN denotes host
T2838 4869-4872 DT denotes the
T2837 4866-4868 IN denotes in
T2836 4857-4865 NN denotes exposure
T2835 4853-4856 DT denotes the
T2834 4850-4852 TO denotes to
T2833 4844-4849 VBZ denotes leads
T2832 4834-4843 NN denotes infection
T2831 4830-4833 NNP denotes IAV
T2830 4828-4829 . denotes .
T2829 4820-4828 JJ denotes critical
T2828 4817-4819 VBZ denotes is
T2827 4807-4816 NNS denotes responses
T2826 4800-4806 JJ denotes immune
T2825 4788-4799 JJ denotes IAV-induced
T2824 4779-4787 VBP denotes regulate
T2823 4774-4778 WDT denotes that
T2822 4763-4773 NNS denotes mechanisms
T2821 4759-4762 DT denotes the
T2820 4756-4758 IN denotes of
T2819 4742-4755 NN denotes understanding
T2818 4740-4741 , denotes ,
T2817 4733-4740 NN denotes context
T2816 4728-4732 DT denotes this
T2815 4725-4727 IN denotes In
T2814 4723-4724 . denotes .
T2813 4713-4723 NNS denotes strategies
T2812 4703-4712 JJ denotes antiviral
T2811 4697-4702 NN denotes novel
T2810 4686-4696 VBG denotes developing
T2809 4683-4685 IN denotes of
T2808 4672-4682 NN denotes importance
T2807 4668-4671 DT denotes the
T2806 4656-4667 VBZ denotes underscores
T2805 4646-4655 JJ denotes potential
T2804 4637-4645 JJ denotes pandemic
T2803 4632-4636 IN denotes with
T2802 4624-4631 NNS denotes viruses
T2801 4614-4623 NN denotes influenza
T2800 4611-4613 IN denotes of
T2799 4603-4610 NNS denotes strains
T2798 4588-4602 JJ denotes drug-resistant
T2797 4585-4587 IN denotes of
T2796 4575-4584 NN denotes Emergence
T2795 4573-4574 . denotes .
T2794 4565-4573 NN denotes response
T2793 4552-4564 JJ denotes inflammatory
T2792 4547-4551 NN denotes host
T2791 4537-4546 JJ denotes excessive
T2790 4534-4536 DT denotes an
T2789 4531-4533 TO denotes to
T2788 4527-4530 JJ denotes due
T2787 4524-4526 VB denotes be
T2786 4521-4523 TO denotes to
T2785 4512-4520 VBN denotes believed
T2784 4502-4511 RB denotes generally
T2783 4499-4501 VBZ denotes is
T2782 4493-4498 WDT denotes which
T2781 4491-4492 , denotes ,
T2780 4482-4491 NN denotes mortality
T2779 4469-4481 JJ denotes considerable
T2778 4462-4468 VBZ denotes causes
T2777 4457-4461 WDT denotes that
T2776 4449-4456 NN denotes disease
T2775 4437-4448 JJ denotes respiratory
T2774 4431-4436 JJ denotes acute
T2773 4420-4430 JJ denotes contagious
T2772 4418-4419 DT denotes a
T2771 4415-4417 IN denotes of
T2770 4409-4414 NN denotes agent
T2769 4397-4408 JJ denotes etiological
T2768 4393-4396 DT denotes the
T2767 4390-4392 VBZ denotes is
T2766 4388-4389 -RRB- denotes )
T2765 4385-4388 NNP denotes IAV
T2764 4384-4385 -LRB- denotes (
T2763 4378-4383 NN denotes virus
T2762 4376-4377 NNP denotes A
T2761 4366-4375 NNP denotes Influenza
T2760 4364-4365 . denotes .
T2759 4363-4364 NNP denotes ]
T2758 4362-4363 CD denotes 9
T2757 4361-4362 VBP denotes [
T2756 4352-4360 NNS denotes proteins
T2755 4342-4351 JJ denotes antiviral
T2754 4339-4341 IN denotes of
T2753 4328-4338 NN denotes production
T2752 4324-4327 DT denotes the
T2751 4320-4323 IN denotes for
T2750 4312-4319 NNS denotes sensors
T2749 4308-4311 NNP denotes DNA
T2748 4304-4307 CC denotes and
T2747 4300-4303 NNP denotes RNA
T2746 4290-4299 JJ denotes cytosolic
T2745 4286-4289 DT denotes the
T2744 4283-4285 IN denotes on
T2743 4276-4282 VBP denotes depend
T2742 4274-4275 , denotes ,
T2741 4263-4274 NNS denotes fibroblasts
T2740 4259-4262 CC denotes and
T2739 4247-4258 NNS denotes macrophages
T2738 4245-4246 , denotes ,
T2737 4244-4245 -RRB- denotes )
T2736 4241-4244 NNP denotes cDC
T2735 4240-4241 -LRB- denotes (
T2734 4237-4239 NNP denotes DC
T2733 4224-4236 JJ denotes conventional
T2732 4214-4223 VBG denotes including
T2731 4212-4213 , denotes ,
T2730 4207-4212 NNS denotes types
T2729 4202-4206 NN denotes cell
T2728 4196-4201 JJ denotes other
T2727 4191-4195 RBS denotes most
T2726 4185-4190 IN denotes while
T2725 4183-4184 , denotes ,
T2724 4182-4183 -RRB- denotes )
T2723 4179-4182 NNP denotes pDC
T2722 4178-4179 -LRB- denotes (
T2721 4172-4177 NNS denotes cells
T2504 3027-3035 NN denotes response
T2503 3020-3026 JJ denotes immune
T2502 3010-3019 JJ denotes antiviral
T2501 3003-3009 NN denotes innate
T2500 2992-3002 JJ denotes protective
T2499 2990-2991 DT denotes a
T2498 2987-2989 IN denotes of
T2497 2976-2986 NN denotes initiation
T2496 2972-2975 DT denotes The
T2495 2970-2971 . denotes .
T2494 2959-2970 NN denotes replication
T2493 2953-2958 PRP$ denotes their
T2492 2949-2952 IN denotes for
T2491 2944-2948 NN denotes cell
T2490 2939-2943 NN denotes host
T2489 2935-2938 DT denotes the
T2488 2932-2934 IN denotes on
T2487 2925-2931 VBP denotes depend
T2486 2919-2924 WDT denotes which
T2485 2909-2918 NNS denotes pathogens
T2484 2901-2908 JJ denotes diverse
T2483 2894-2900 RB denotes highly
T2482 2891-2893 IN denotes of
T2481 2885-2890 NN denotes class
T2480 2883-2884 DT denotes a
T2479 2879-2882 VBP denotes are
T2478 2871-2878 NNS denotes Viruses
T534 1586-1587 . denotes .
T533 1576-1586 NNS denotes infections
T532 1572-1575 NNP denotes IAV
T531 1569-1571 IN denotes of
T530 1558-1568 NN denotes management
T529 1554-1557 DT denotes the
T528 1551-1553 IN denotes in
T527 1542-1550 NN denotes interest
T526 1539-1541 IN denotes of
T525 1536-1538 VB denotes be
T524 1530-1535 MD denotes might
T523 1526-1529 NNP denotes A20
T522 1523-1525 IN denotes of
T521 1512-1522 NN denotes inhibition
T520 1501-1511 NNS denotes conditions
T519 1493-1500 JJ denotes certain
T518 1487-1492 IN denotes under
T517 1482-1486 IN denotes that
T516 1474-1481 VBP denotes suggest
T515 1470-1473 CC denotes and
T514 1468-1469 , denotes ,
T513 1459-1468 NN denotes lethality
T512 1447-1458 JJ denotes IAV-induced
T511 1442-1446 IN denotes with
T510 1431-1441 VBN denotes associated
T509 1428-1430 VBZ denotes is
T508 1419-1427 NN denotes response
T507 1403-1418 JJ denotes proinflammatory
T506 1398-1402 NN denotes host
T505 1388-1397 JJ denotes excessive
T504 1385-1387 DT denotes an
T503 1380-1384 IN denotes that
T502 1373-1379 NN denotes belief
T501 1365-1372 JJ denotes general
T500 1361-1364 DT denotes the
T499 1351-1360 VBP denotes challenge
T498 1343-1350 NNS denotes results
T497 1337-1342 DT denotes These
T496 1335-1336 . denotes .
T495 1326-1335 NN denotes infection
T494 1322-1325 NNP denotes IAV
T493 1315-1321 JJ denotes lethal
T492 1307-1314 IN denotes against
T491 1297-1306 VBN denotes protected
T490 1293-1296 VBP denotes are
T489 1288-1292 NNS denotes mice
T488 1279-1287 NN denotes knockout
T487 1275-1278 NNP denotes A20
T486 1266-1274 JJ denotes specific
T485 1261-1265 NN denotes cell
T484 1253-1260 JJ denotes myeloid
T483 1251-1252 , denotes ,
T482 1239-1251 RB denotes Surprisingly
T481 1237-1238 . denotes .
T480 1233-1237 NNS denotes mice
T479 1224-1232 JJ denotes infected
T478 1220-1223 NNP denotes IAV
T477 1217-1219 IN denotes of
T476 1211-1216 NNS denotes lungs
T475 1207-1210 DT denotes the
T474 1204-1206 IN denotes in
T473 1192-1203 NNS denotes neutrophils
T472 1188-1191 CC denotes and
T471 1176-1187 NNS denotes macrophages
T470 1167-1175 JJ denotes alveolar
T469 1164-1166 IN denotes of
T468 1157-1163 NN denotes number
T467 1147-1156 VBN denotes increased
T466 1144-1146 DT denotes an
T465 1139-1143 IN denotes with
T464 1128-1138 VBN denotes associated
T463 1124-1127 VBD denotes was
T462 1119-1123 DT denotes this
T461 1114-1118 NN denotes vivo
T460 1111-1113 IN denotes In
T459 1109-1110 . denotes .
T458 1099-1109 VBP denotes interferon
T457 1097-1098 PRP denotes I
T456 1092-1096 NN denotes type
T455 1088-1091 CC denotes and
T454 1077-1087 NNS denotes chemokines
T453 1075-1076 , denotes ,
T452 1066-1075 NNS denotes cytokines
T451 1050-1065 JJ denotes proinflammatory
T450 1047-1049 IN denotes of
T449 1036-1046 NN denotes production
T448 1026-1035 JJ denotes increased
T447 1021-1025 IN denotes with
T446 1009-1020 NN denotes concomitant
T445 1007-1008 , denotes ,
T444 997-1007 NN denotes activation
T443 992-996 JJ denotes IRF3
T442 988-991 CC denotes and
T441 982-987 NN denotes NF-κB
T440 973-981 JJ denotes enhanced
T439 970-972 IN denotes by
T438 958-969 VBN denotes illustrated
T437 955-957 IN denotes as
T436 953-954 , denotes ,
T435 944-953 NN denotes infection
T434 940-943 NNP denotes IAV
T433 936-939 CC denotes and
T432 932-935 NNP denotes RNA
T431 923-931 VBN denotes stranded
T430 916-922 VB denotes double
T429 913-915 TO denotes to
T428 897-912 JJ denotes hyperresponsive
T427 892-896 VBD denotes were
T426 880-891 NNS denotes macrophages
T425 870-879 JJ denotes deficient
T424 866-869 CD denotes A20
T423 864-865 . denotes .
T422 855-864 NN denotes infection
T421 851-854 NNP denotes IAV
T420 848-850 TO denotes to
T419 842-847 NNS denotes cells
T418 834-841 JJ denotes myeloid
T417 831-833 IN denotes of
T416 822-830 NN denotes response
T415 818-821 DT denotes the
T414 815-817 IN denotes in
T413 811-814 NNP denotes A20
T412 803-810 NN denotes protein
T411 785-802 JJ denotes ubiquitin-editing
T410 781-784 DT denotes the
T409 778-780 IN denotes of
T408 773-777 NN denotes role
T407 769-772 DT denotes the
T406 761-768 VB denotes examine
T405 758-760 TO denotes to
T404 753-757 NNS denotes mice
T403 744-752 NN denotes knockout
T402 740-743 NNP denotes A20
T401 731-739 JJ denotes specific
T400 726-730 NN denotes cell
T399 718-725 JJ denotes myeloid
T398 713-717 VBD denotes used
T397 710-712 PRP denotes we
T396 705-709 RB denotes Here
T395 703-704 . denotes .
T394 693-703 NNS denotes strategies
T393 681-692 JJ denotes therapeutic
T392 675-680 JJ denotes novel
T391 667-674 VB denotes develop
T390 664-666 TO denotes to
T389 653-663 NN denotes importance
T388 649-652 JJ denotes key
T387 646-648 IN denotes of
T386 643-645 VBZ denotes is
T385 635-642 NNS denotes viruses
T384 629-634 JJ denotes other
T383 625-628 CC denotes and
T382 621-624 NNP denotes IAV
T381 618-620 TO denotes to
T380 608-617 NNS denotes responses
T379 601-607 JJ denotes immune
T378 594-600 JJ denotes innate
T377 585-593 VBP denotes regulate
T376 580-584 WDT denotes that
T375 569-579 NNS denotes mechanisms
T374 565-568 DT denotes the
T373 551-564 VBG denotes Understanding
T372 549-550 . denotes .
T371 539-549 NN denotes interferon
T370 529-538 JJ denotes antiviral
T369 525-528 CC denotes and
T368 515-524 NNS denotes cytokines
T367 499-514 JJ denotes proinflammatory
T366 496-498 IN denotes of
T365 485-495 NN denotes production
T364 481-484 DT denotes the
T363 473-480 VBZ denotes induces
T362 469-472 CC denotes and
T361 463-468 NNP denotes RIG-I
T360 454-462 NN denotes receptor
T359 442-453 NN denotes recognition
T358 433-441 NN denotes pathogen
T357 419-432 JJ denotes intracellular
T356 415-418 DT denotes the
T355 405-414 VBZ denotes activates
T354 399-404 WDT denotes which
T353 397-398 , denotes ,
T352 392-397 NN denotes cycle
T351 387-391 NN denotes life
T350 375-386 NN denotes replication
T349 371-374 DT denotes the
T348 364-370 IN denotes during
T347 351-363 JJ denotes intermediate
T346 348-350 DT denotes an
T345 345-347 IN denotes as
T344 341-344 NNP denotes RNA
T343 325-340 JJ denotes double-stranded
T342 316-324 VBZ denotes produces
T341 314-315 -RRB- denotes )
T340 311-314 NNP denotes IAV
T339 310-311 -LRB- denotes (
T338 304-309 NN denotes virus
T337 302-303 NNP denotes A
T336 292-301 NNP denotes Influenza
T335 290-291 . denotes .
T334 281-290 NNS denotes molecules
T333 271-280 JJ denotes microbial
T332 262-270 JJ denotes specific
T331 259-261 TO denotes to
T330 248-258 VBG denotes responding
T329 245-247 IN denotes by
T328 235-244 NNS denotes pathogens
T327 229-234 JJ denotes other
T326 225-228 CC denotes and
T325 217-224 NNS denotes viruses
T324 209-216 IN denotes against
T323 201-208 NN denotes defense
T322 198-200 IN denotes of
T321 193-197 NN denotes line
T320 187-192 JJ denotes first
T319 183-186 DT denotes the
T318 174-182 VBZ denotes provides
T317 165-173 NN denotes response
T316 158-164 JJ denotes immune
T315 151-157 NN denotes innate
T314 147-150 NNP denotes The
T15885 34558-34559 -RRB- denotes )
T15884 34553-34558 NNP denotes Sigma
T15883 34551-34552 : denotes ;
T15882 34543-34551 NN denotes filtrate
T15881 34531-34542 NNP denotes RDE/Cholera
T15880 34530-34531 -LRB- denotes (
T15892 34594-34602 NNS denotes proteins
T15891 34588-34593 NN denotes serum
T15890 34583-34587 IN denotes from
T15889 34577-34582 NNS denotes acids
T15888 34570-34576 JJ denotes sialic
T15887 34563-34569 VB denotes remove
T15886 34560-34562 TO denotes to
T15879 34523-34529 NN denotes enzyme
T15878 34503-34522 JJ denotes receptor-destroying
T15877 34498-34502 IN denotes with
T15876 34490-34497 VBN denotes treated
T15875 34485-34489 VBD denotes were
T15874 34479-34484 DT denotes these
T15873 34476-34478 IN denotes of
T15872 34471-34475 NN denotes sera
T15871 34469-34470 , denotes ,
T15870 34465-34469 NNS denotes mice
T15869 34456-34464 JJ denotes infected
T15868 34453-34455 IN denotes in
T15867 34446-34452 NNS denotes titers
T15866 34442-34445 NNP denotes HAI
T15865 34438-34441 DT denotes the
T15864 34428-34437 VB denotes determine
T15863 34425-34427 TO denotes To
T15862 34418-34424 NNS denotes titers
T15861 34416-34417 -RRB- denotes )
T15860 34406-34416 NN denotes inhibition
T15859 34389-34405 NN denotes hemagglutination
T15858 34388-34389 -LRB- denotes (
T15857 34384-34387 NNP denotes HAI
T15856 34381-34383 IN denotes of
T15855 34367-34380 NN denotes Determination
T16043 35372-35373 . denotes .
T16042 35368-35372 VBN denotes used
T16041 35364-35367 VBD denotes was
T16040 35359-35363 NNP denotes X-47
T16039 35356-35358 IN denotes of
T16038 35351-35355 NN denotes dose
T16037 35341-35350 JJ denotes sublethal
T16036 35339-35340 DT denotes a
T16035 35334-35338 IN denotes with
T16034 35328-35333 RB denotes twice
T16033 35319-35327 JJ denotes infected
T16032 35313-35318 NN denotes mouse
T16031 35311-35312 DT denotes a
T16030 35306-35310 IN denotes from
T16029 35300-35305 NN denotes serum
T16028 35298-35299 , denotes ,
T16027 35291-35298 NN denotes control
T16026 35282-35290 JJ denotes positive
T16025 35279-35281 IN denotes as
T16024 35277-35278 : denotes ;
T16023 35276-35277 -RRB- denotes )
T16022 35272-35276 NN denotes sera
T16021 35269-35271 IN denotes of
T16020 35262-35268 NN denotes effect
T16019 35248-35261 NN denotes agglutination
T16018 35244-35247 IN denotes for
T16017 35236-35243 NN denotes control
T16016 35235-35236 -LRB- denotes (
T16015 35229-35234 NN denotes virus
T16014 35224-35228 NNP denotes X-47
T13114 25423-25428 NN denotes study
T13113 25415-25422 JJ denotes present
T13112 25411-25414 DT denotes the
T13111 25408-25410 IN denotes In
T10069 18058-18067 VBD denotes recovered
T13230 26096-26102 IN denotes during
T13229 26091-26095 NN denotes lung
T13228 26087-26090 DT denotes the
T13227 26084-26086 TO denotes to
T13226 26078-26083 NNS denotes cells
T13225 26071-26077 JJ denotes immune
T13224 26064-26070 JJ denotes innate
T13223 26056-26063 VBP denotes attract
T13222 26051-26055 WDT denotes that
T13221 26040-26050 NNS denotes chemokines
T13220 26036-26039 CC denotes and
T13219 26026-26035 NNS denotes cytokines
T13218 26010-26025 JJ denotes proinflammatory
T13217 26007-26009 IN denotes of
T13216 26000-26006 NN denotes source
T13215 25990-25999 JJ denotes important
T13214 25987-25989 DT denotes an
T13213 25983-25986 VBP denotes are
T13212 25978-25982 PRP denotes They
T13211 25976-25977 . denotes .
T13210 25975-25976 NNP denotes ]
T13209 25973-25975 CD denotes 68
T13208 25972-25973 NNP denotes [
T13207 25970-25971 , denotes ,
T13206 25969-25970 NNP denotes ]
T13205 25967-25969 CD denotes 67
T13204 25966-25967 NNP denotes [
T13273 26336-26338 TO denotes to
T10068 18054-18057 CC denotes and
T10002 17656-17664 VBZ denotes protects
T10001 17650-17655 NNS denotes cells
T10000 17642-17649 JJ denotes myeloid
T9999 17639-17641 IN denotes in
T9998 17628-17638 NN denotes deficiency
T9997 17624-17627 CD denotes A20
T10074 18090-18099 NN denotes challenge
T10073 18084-18089 JJ denotes viral
T10072 18080-18083 DT denotes the
T10071 18075-18079 IN denotes from
T10070 18068-18074 RBR denotes faster
T10950 23683-23688 NNP denotes MIP-2
T10949 23679-23682 CC denotes and
T10948 23676-23678 NNP denotes KC
T11043 24192-24197 JJR denotes lower
T11042 24187-24191 RB denotes even
T11076 24370-24379 JJ denotes antiviral
T11075 24367-24369 CC denotes or
T11074 24357-24366 NN denotes clearance
T11073 24351-24356 JJ denotes viral
T11072 24348-24350 IN denotes in
T11071 24336-24347 NNS denotes differences
T11070 24332-24335 DT denotes any
T11069 24325-24331 VB denotes detect
T11068 24321-24324 RB denotes not
T11067 24316-24320 RB denotes also
T11066 24310-24315 MD denotes could
T11065 24307-24309 PRP denotes We
T11064 24305-24306 . denotes .
T11063 24301-24305 NNS denotes mice
T11062 24298-24300 IN denotes of
T11061 24291-24297 NNS denotes groups
T11060 24286-24290 DT denotes both
T11059 24278-24285 IN denotes between
T11058 24268-24277 JJ denotes different
T11057 24264-24267 RB denotes not
T11056 24260-24263 VBD denotes was
T11055 24248-24259 NN denotes recruitment
T11054 24239-24247 JJ denotes monocyte
T11053 24234-24238 RB denotes also
T18024 39205-39213 VBN denotes directed
T18023 39194-39204 NNS denotes antibodies
T18022 39183-39193 JJ denotes monoclonal
T18021 39178-39182 IN denotes with
T11083 24410-24419 NN denotes infection
T11082 24405-24409 NN denotes post
T11081 24403-24404 NN denotes h
T11080 24401-24402 CD denotes 6
T11079 24398-24400 IN denotes at
T11078 24389-24397 NN denotes immunity
T11077 24380-24388 JJ denotes adaptive
T18020 39170-39177 VBN denotes stained
T11085 24421-24427 NN denotes figure
T11084 24420-24421 -LRB- denotes (
T18019 39165-39169 VBD denotes were
T17949 38846-38851 NNS denotes Lungs
T17948 38836-38845 NN denotes cytometry
T17947 38831-38835 NN denotes Flow
T18026 39222-39228 NNP denotes MHC-II
T18025 39214-39221 IN denotes against
T18018 39159-39164 NNS denotes Cells
T18017 39157-39158 . denotes .
T18016 39153-39157 NNP denotes EDTA
T18015 39150-39152 NNP denotes mM
T18014 39148-39149 CD denotes 1
T18013 39143-39147 IN denotes with
T18012 39138-39142 NNP denotes HBSS
T18011 39133-39137 IN denotes with
T18010 39127-39132 NNS denotes times
T18009 39125-39126 CD denotes 4
T18008 39117-39124 VBN denotes flushed
T18007 39113-39116 VBD denotes was
T18006 39107-39112 NNS denotes lumen
T18005 39100-39106 NN denotes airway
T18004 39096-39099 CC denotes and
T18003 39086-39095 VBN denotes canulated
T18002 39081-39085 VBD denotes were
T18001 39073-39080 NN denotes trachea
T18000 39071-39072 , denotes ,
T17999 39068-39071 NNP denotes BAL
T17998 39065-39067 IN denotes of
T17997 39053-39064 NN denotes preparation
T15522 33703-33706 IN denotes For
T15521 33701-33702 . denotes .
T15520 33689-33701 RB denotes intranasally
T15519 33676-33688 VBN denotes administered
T15518 33672-33675 VBD denotes was
T15484 33503-33513 VBN denotes propagated
T15483 33499-33502 VBD denotes was
T15482 33497-33498 -RRB- denotes )
T15481 33495-33497 CD denotes 75
T15480 33494-33495 VBD denotes /
T15479 33482-33494 NNP denotes A/Victoria/3
T15478 33481-33482 NNP denotes ×
T15477 33478-33481 NNP denotes PR8
T15476 33476-33477 : denotes ;
T15475 33472-33476 NNP denotes H3N2
T15474 33471-33472 -LRB- denotes (
T15473 33466-33470 NNP denotes X-47
T15472 33462-33465 NNP denotes IAV
T15471 33454-33461 VBD denotes adapted
T15470 33448-33453 NNP denotes Mouse
T15469 33441-33447 NNS denotes titers
T15468 33435-33440 JJ denotes viral
T15467 33432-33434 IN denotes of
T15466 33418-33431 NN denotes determination
T15465 33414-33417 CC denotes and
T15464 33404-33413 NN denotes infection
T15463 33398-33403 JJ denotes Viral
T15541 33827-33828 , denotes ,
T15540 33821-33827 NNS denotes titers
T15539 33815-33820 JJ denotes viral
T15538 33805-33814 JJ denotes pulmonary
T15537 33795-33804 VB denotes determine
T15536 33792-33794 TO denotes To
T15535 33790-33791 . denotes .
T15534 33786-33790 NNP denotes X-47
T15533 33776-33785 JJ denotes 0.05-LD50
T15532 33773-33775 CC denotes or
T15531 33766-33772 JJ denotes 2-LD50
T15530 33753-33765 RB denotes respectively
T15529 33744-33752 VBD denotes received
T15528 33739-33743 NNS denotes mice
T15527 33737-33738 , denotes ,
T15526 33728-33737 NN denotes infection
T15525 33718-33727 JJ denotes sublethal
T15524 33714-33717 CC denotes and
T15523 33707-33713 JJ denotes lethal
T15517 33668-33671 NNP denotes PBS
T15516 33665-33667 IN denotes in
T15515 33657-33664 VBN denotes diluted
T15514 33652-33656 NNP denotes X-47
T15513 33649-33651 NN denotes µl
T15512 33646-33648 CD denotes 50
T15511 33642-33645 CC denotes and
T15510 33640-33641 -RRB- denotes )
T15509 33635-33640 NN denotes mg/kg
T15508 33632-33634 CD denotes 60
T15507 33631-33632 -LRB- denotes (
T15506 33622-33630 NN denotes xylazine
T15505 33618-33621 CC denotes and
T6605 15004-15014 JJ denotes peritoneal
T6604 14998-15003 VBG denotes using
T6603 14989-14997 VBN denotes obtained
T6548 14712-14714 NNP denotes 1C
T6547 14705-14711 NN denotes figure
T6546 14704-14705 -LRB- denotes (
T6545 14698-14703 NNS denotes cells
T6544 14693-14697 NN denotes type
T6543 14688-14692 JJ denotes wild
T6542 14685-14687 TO denotes to
T6541 14676-14684 VBN denotes compared
T6540 14671-14675 NNP denotes BMDM
T6539 14661-14670 JJ denotes deficient
T6538 14657-14660 CD denotes A20
T6537 14654-14656 IN denotes in
T6536 14648-14653 NN denotes point
T6535 14643-14647 NN denotes time
T6534 14635-14642 JJR denotes earlier
T6533 14632-14634 DT denotes an
T6532 14629-14631 IN denotes at
T6531 14621-14628 NN denotes maximum
T6530 14617-14620 PRP$ denotes its
T6529 14609-14616 VBD denotes reached
T6528 14595-14608 NN denotes translocation
T6527 14587-14594 JJ denotes nuclear
T6637 15206-15207 . denotes .
T300 0-3 CD denotes A20
T301 4-5 -LRB- denotes (
T302 5-12 NN denotes Tnfaip3
T303 12-13 -RRB- denotes )
T304 14-24 NN denotes Deficiency
T305 25-27 IN denotes in
T306 28-35 NNP denotes Myeloid
T307 36-41 NNP denotes Cells
T308 42-50 VBZ denotes Protects
T309 51-58 IN denotes against
T310 59-68 NNP denotes Influenza
T311 69-70 NNP denotes A
T6636 15195-15206 NNS denotes macrophages
T6635 15187-15194 JJ denotes primary
T6634 15184-15186 IN denotes in
T6633 15173-15183 NN denotes activation
T6632 15168-15172 JJ denotes IRF3
T6631 15164-15167 CC denotes and
T6630 15158-15163 NN denotes NF-κB
T6629 15144-15157 JJ denotes RIG-I-induced
T6628 15141-15143 IN denotes of
T6627 15130-15140 NN denotes regulation
T6626 15121-15129 JJ denotes negative
T6625 15117-15120 DT denotes the
T6624 15114-15116 IN denotes in
T6623 15109-15113 NN denotes role
T6622 15099-15108 JJ denotes important
T6621 15096-15098 DT denotes an
T6620 15090-15095 VBZ denotes plays
T6619 15086-15089 NNP denotes A20
T6618 15081-15085 IN denotes that
T6617 15069-15080 VBP denotes demonstrate
T6616 15061-15068 NNS denotes results
T6615 15055-15060 DT denotes these
T6614 15053-15054 , denotes ,
T6613 15045-15053 RB denotes Together
T6612 15043-15044 . denotes .
T6611 15042-15043 -RRB- denotes )
T6610 15037-15042 VBN denotes shown
T6609 15033-15036 RB denotes not
T6608 15028-15032 NNS denotes data
T6607 15027-15028 -LRB- denotes (
T6606 15015-15026 NNS denotes macrophages
T3647 9431-9432 . denotes .
T3646 9422-9431 NN denotes potential
T3645 9410-9421 JJ denotes therapeutic
T3644 9405-9409 VB denotes have
T3643 9399-9404 MD denotes might
T3642 9393-9398 NNS denotes cells
T3641 9385-9392 JJ denotes myeloid
T3640 9382-9384 IN denotes in
T3639 9373-9381 NN denotes activity
T3638 9369-9372 JJ denotes A20
T3637 9359-9368 VBG denotes targeting
T3636 9356-9358 IN denotes by
T3635 9352-9355 NNP denotes IAV
T3634 9349-9351 TO denotes to
T3633 9340-9348 NN denotes response
T3632 9333-9339 JJ denotes immune
T3631 9326-9332 NN denotes innate
T3630 9322-9325 DT denotes the
T3629 9313-9321 VBG denotes boosting
T3628 9308-9312 IN denotes that
T3627 9300-9307 VBP denotes suggest
T3626 9292-9299 NNS denotes results
T3625 9286-9291 DT denotes These
T3624 9284-9285 . denotes .
T3623 9275-9284 NN denotes clearance
T3622 9269-9274 JJ denotes viral
T3621 9260-9268 JJ denotes enhanced
T3620 9256-9259 CC denotes and
T3619 9254-9255 , denotes ,
T3618 9243-9254 NNS denotes macrophages
T3617 9234-9242 JJ denotes alveolar
T3616 9230-9233 CC denotes and
T3615 9219-9229 NNS denotes neutophils
T3614 9216-9218 IN denotes as
T3613 9211-9215 JJ denotes such
T16307 35568-35569 -LRB- denotes (
T16306 35566-35567 NNP denotes A
T16305 35556-35565 NNP denotes Brefeldin
T16304 35553-35555 NN denotes µg
T16303 35550-35552 CD denotes 50
T16302 35545-35549 IN denotes with
T16301 35532-35544 RB denotes intranasally
T16300 35527-35531 NNS denotes mice
T16299 35523-35526 DT denotes the
T16298 35514-35522 VBG denotes treating
T16297 35511-35513 IN denotes by
T16296 35500-35510 VBN denotes determined
T16295 35495-35499 VBD denotes were
T16294 35489-35494 NNS denotes cells
T16293 35487-35488 NNP denotes T
T16292 35485-35486 CD denotes +
T16291 35482-35485 CD denotes CD8
T16290 35471-35481 VBG denotes expressing
T16289 35466-35470 NNP denotes IFNγ
T16288 35462-35465 CC denotes and
T16287 35460-35461 -RRB- denotes )
T16286 35457-35460 NNP denotes GrB
T16285 35456-35457 -LRB- denotes (
T16284 35454-35455 NNP denotes B
T16283 35445-35453 NNP denotes Granzyme
T16282 35439-35444 NNS denotes cells
T16281 35437-35438 NNP denotes T
T16280 35435-35436 CD denotes +
T16279 35432-35435 NNP denotes CD8
T16278 35422-35431 VBN denotes activated
T16277 35419-35421 IN denotes of
T16276 35410-35418 NN denotes staining
T16275 35405-35409 NNP denotes IFNγ
T16274 35401-35404 CC denotes and
T16273 35397-35400 NNP denotes GrB
T16272 35383-35396 JJ denotes intracellular
T16271 35378-35382 NN denotes vivo
T16270 35375-35377 IN denotes In
T21035 19303-19312 NN denotes detection
T21034 19299-19302 DT denotes the
T21033 19288-19298 VBZ denotes represents
T21032 19283-19287 NN denotes line
T21031 19276-19282 VBN denotes dashed
T21030 19272-19275 DT denotes The
T21029 19270-19271 . denotes .
T21028 19269-19270 -RRB- denotes )
T21027 19268-19269 NN denotes B
T21026 19267-19268 -LRB- denotes (
T21025 19260-19266 CD denotes TCID50
T21024 19255-19259 JJ denotes mean
T21023 19252-19254 IN denotes as
T21022 19242-19251 VBN denotes expressed
T21021 19238-19241 CC denotes and
T21020 19229-19237 VBN denotes measured
T21019 19224-19228 VBD denotes were
T21018 19219-19223 NN denotes lung
T21017 19215-19218 DT denotes the
T21016 19212-19214 IN denotes in
T21015 19205-19211 NNS denotes titers
T21014 19199-19204 JJ denotes viral
T21013 19197-19198 -RRB- denotes )
T21012 19193-19197 FW denotes p.i.
T21011 19192-19193 -LRB- denotes (
T21010 19182-19191 NN denotes infection
T21009 19177-19181 NN denotes post
T21008 19174-19176 CD denotes 10
T21007 19170-19173 CC denotes and
T21006 19168-19169 CD denotes 7
T21005 19166-19167 , denotes ,
T21004 19165-19166 CD denotes 4
T21003 19161-19164 NN denotes day
T21002 19158-19160 IN denotes At
T21001 19156-19157 . denotes .
T21000 19155-19156 -RRB- denotes )
T20999 19154-19155 NNP denotes A
T20998 19153-19154 -LRB- denotes (
T20997 19143-19152 VBN denotes monitored
T20996 19139-19142 VBD denotes was
T20995 19134-19138 NN denotes loss
T20994 19127-19133 NN denotes weight
T20993 19123-19126 CC denotes and
T21079 19511-19512 -RRB- denotes )
T21078 19510-19511 NNP denotes C
T21077 19509-19510 -LRB- denotes (
T21076 19496-19508 NNS denotes technologies
T21075 19483-19495 VBG denotes multiplexing
T21074 19479-19482 CC denotes and
T21073 19473-19478 NNP denotes ELISA
T21072 19470-19472 IN denotes by
T21071 19461-19469 VBN denotes analyzed
T21070 19456-19460 VBD denotes were
T21069 19449-19455 NNS denotes levels
T21068 19441-19448 NN denotes protein
T21067 19436-19440 NNP denotes IFNα
T21066 19432-19435 CC denotes and
T21065 19427-19431 NNP denotes IL-6
T21064 19425-19426 , denotes ,
T21063 19420-19425 NNP denotes MCP-1
T21062 19418-19419 , denotes ,
T21061 19413-19418 NNP denotes MIP-2
T21060 19411-19412 , denotes ,
T21059 19409-19411 NNP denotes KC
T21058 19405-19408 CC denotes and
T21057 19400-19404 JJ denotes p.i.
T21056 19395-19399 NNS denotes days
T21055 19392-19394 CD denotes 10
T21054 19388-19391 CC denotes and
T21053 19386-19387 CD denotes 7
T21052 19384-19385 , denotes ,
T21051 19383-19384 CD denotes 4
T21050 19380-19382 IN denotes at
T21049 19375-19379 NNS denotes mice
T21048 19366-19374 JJ denotes infected
R232 T312 T313 compound Virus,Infection
R233 T313 T311 meta Infection,A
R234 T314 T317 det The,response
R235 T315 T317 amod innate,response
R236 T316 T317 amod immune,response
R237 T317 T318 nsubj response,provides
R238 T318 T308 conj provides,Protects
R239 T319 T321 det the,line
R240 T320 T321 amod first,line
R241 T321 T318 dobj line,provides
R242 T322 T321 prep of,line
R243 T323 T322 pobj defense,of
R244 T324 T321 prep against,line
R245 T325 T324 pobj viruses,against
R246 T326 T325 cc and,viruses
R247 T327 T328 amod other,pathogens
R248 T328 T325 conj pathogens,viruses
R249 T329 T318 prep by,provides
R250 T330 T329 pcomp responding,by
R251 T331 T330 prep to,responding
R252 T332 T334 amod specific,molecules
R253 T333 T334 amod microbial,molecules
R254 T334 T331 pobj molecules,to
R255 T335 T318 punct .,provides
R256 T336 T342 nsubj Influenza,produces
R257 T337 T338 det A,virus
R258 T338 T336 appos virus,Influenza
R259 T339 T340 punct (,IAV
R260 T340 T338 appos IAV,virus
R261 T341 T338 punct ),virus
R262 T342 T342 ROOT produces,produces
R263 T343 T344 amod double-stranded,RNA
R264 T344 T342 dobj RNA,produces
R265 T345 T342 prep as,produces
R266 T346 T347 det an,intermediate
R267 T347 T345 pobj intermediate,as
R268 T348 T342 prep during,produces
R269 T349 T352 det the,cycle
R270 T350 T352 compound replication,cycle
R271 T351 T352 compound life,cycle
R272 T352 T348 pobj cycle,during
R273 T353 T352 punct ",",cycle
R274 T354 T355 nsubj which,activates
R275 T355 T352 relcl activates,cycle
R276 T356 T359 det the,recognition
R277 T357 T359 amod intracellular,recognition
R278 T358 T359 compound pathogen,recognition
R279 T359 T355 dobj recognition,activates
R280 T360 T361 compound receptor,RIG-I
R281 T361 T359 appos RIG-I,recognition
R282 T362 T355 cc and,activates
R283 T363 T355 conj induces,activates
R284 T364 T365 det the,production
R285 T365 T363 dobj production,induces
R286 T366 T365 prep of,production
R287 T367 T368 amod proinflammatory,cytokines
R288 T368 T366 pobj cytokines,of
R289 T369 T368 cc and,cytokines
R290 T370 T371 amod antiviral,interferon
R291 T371 T368 conj interferon,cytokines
R292 T372 T342 punct .,produces
R293 T373 T386 csubj Understanding,is
R294 T374 T375 det the,mechanisms
R295 T375 T373 dobj mechanisms,Understanding
R296 T376 T377 nsubj that,regulate
R297 T377 T375 relcl regulate,mechanisms
R298 T378 T380 amod innate,responses
R299 T379 T380 amod immune,responses
R300 T380 T377 dobj responses,regulate
R301 T381 T380 prep to,responses
R302 T382 T381 pobj IAV,to
R303 T383 T382 cc and,IAV
R304 T384 T385 amod other,viruses
R305 T385 T382 conj viruses,IAV
R306 T386 T386 ROOT is,is
R307 T387 T386 prep of,is
R308 T388 T389 amod key,importance
R309 T389 T387 pobj importance,of
R310 T390 T391 aux to,develop
R311 T391 T386 advcl develop,is
R312 T392 T394 amod novel,strategies
R313 T393 T394 amod therapeutic,strategies
R314 T394 T391 dobj strategies,develop
R315 T395 T386 punct .,is
R316 T396 T398 advmod Here,used
R317 T397 T398 nsubj we,used
R318 T398 T398 ROOT used,used
R319 T399 T400 compound myeloid,cell
R320 T400 T398 dobj cell,used
R321 T401 T404 amod specific,mice
R322 T402 T404 compound A20,mice
R323 T403 T404 compound knockout,mice
R324 T404 T400 dobj mice,cell
R325 T405 T406 aux to,examine
R326 T406 T400 advcl examine,cell
R327 T407 T408 det the,role
R328 T408 T406 dobj role,examine
R329 T409 T408 prep of,role
R330 T410 T412 det the,protein
R331 T411 T412 compound ubiquitin-editing,protein
R332 T412 T409 pobj protein,of
R333 T413 T412 appos A20,protein
R334 T414 T408 prep in,role
R335 T415 T416 det the,response
R336 T416 T414 pobj response,in
R337 T417 T416 prep of,response
R338 T418 T419 amod myeloid,cells
R339 T419 T417 pobj cells,of
R340 T420 T416 prep to,response
R341 T421 T422 compound IAV,infection
R342 T422 T420 pobj infection,to
R343 T423 T398 punct .,used
R344 T424 T426 nummod A20,macrophages
R345 T425 T426 amod deficient,macrophages
R346 T426 T427 nsubj macrophages,were
R347 T427 T427 ROOT were,were
R348 T428 T427 acomp hyperresponsive,were
R349 T429 T430 aux to,double
R350 T430 T428 xcomp double,hyperresponsive
R351 T431 T432 amod stranded,RNA
R352 T432 T430 dobj RNA,double
R353 T433 T432 cc and,RNA
R354 T434 T435 compound IAV,infection
R355 T435 T432 conj infection,RNA
R356 T436 T427 punct ",",were
R357 T437 T438 mark as,illustrated
R358 T438 T427 advcl illustrated,were
R359 T439 T438 agent by,illustrated
R360 T440 T441 amod enhanced,NF-κB
R361 T441 T439 pobj NF-κB,by
R362 T442 T441 cc and,NF-κB
R363 T443 T444 amod IRF3,activation
R364 T444 T441 conj activation,NF-κB
R365 T445 T444 punct ",",activation
R366 T446 T444 conj concomitant,activation
R367 T447 T441 prep with,NF-κB
R368 T448 T449 amod increased,production
R369 T449 T447 pobj production,with
R370 T450 T449 prep of,production
R371 T451 T452 amod proinflammatory,cytokines
R372 T452 T450 pobj cytokines,of
R373 T453 T452 punct ",",cytokines
R374 T454 T452 conj chemokines,cytokines
R375 T455 T454 cc and,chemokines
R376 T456 T454 conj type,chemokines
R377 T457 T458 nsubj I,interferon
R378 T458 T452 relcl interferon,cytokines
R379 T459 T427 punct .,were
R380 T460 T464 prep In,associated
R381 T461 T460 pobj vivo,In
R382 T462 T464 nsubjpass this,associated
R383 T463 T464 auxpass was,associated
R384 T464 T464 ROOT associated,associated
R385 T465 T464 prep with,associated
R386 T466 T468 det an,number
R387 T467 T468 amod increased,number
R388 T468 T465 pobj number,with
R389 T469 T468 prep of,number
R390 T470 T471 amod alveolar,macrophages
R391 T471 T469 pobj macrophages,of
R392 T472 T471 cc and,macrophages
R393 T473 T471 conj neutrophils,macrophages
R394 T474 T468 prep in,number
R395 T475 T476 det the,lungs
R396 T476 T474 pobj lungs,in
R397 T477 T476 prep of,lungs
R398 T478 T480 nmod IAV,mice
R399 T479 T480 amod infected,mice
R400 T480 T477 pobj mice,of
R401 T481 T464 punct .,associated
R402 T482 T491 advmod Surprisingly,protected
R403 T483 T491 punct ",",protected
R404 T484 T485 amod myeloid,cell
R405 T485 T489 amod cell,mice
R406 T486 T489 amod specific,mice
R407 T487 T489 compound A20,mice
R408 T488 T489 compound knockout,mice
R409 T489 T491 nsubjpass mice,protected
R410 T490 T491 auxpass are,protected
R411 T491 T491 ROOT protected,protected
R412 T492 T491 prep against,protected
R413 T493 T495 amod lethal,infection
R414 T494 T495 compound IAV,infection
R415 T495 T492 pobj infection,against
R416 T496 T491 punct .,protected
R417 T497 T498 det These,results
R418 T498 T499 nsubj results,challenge
R419 T499 T499 ROOT challenge,challenge
R420 T500 T502 det the,belief
R421 T501 T502 amod general,belief
R422 T502 T499 dobj belief,challenge
R423 T503 T510 mark that,associated
R424 T504 T508 det an,response
R425 T505 T506 amod excessive,host
R426 T506 T508 amod host,response
R427 T507 T508 amod proinflammatory,response
R428 T508 T510 nsubjpass response,associated
R429 T509 T510 auxpass is,associated
R430 T510 T502 acl associated,belief
R431 T511 T510 prep with,associated
R432 T512 T513 amod IAV-induced,lethality
R433 T513 T511 pobj lethality,with
R434 T514 T510 punct ",",associated
R435 T515 T510 cc and,associated
R436 T516 T499 conj suggest,challenge
R437 T517 T525 mark that,be
R438 T518 T525 prep under,be
R439 T519 T520 amod certain,conditions
R440 T520 T518 pobj conditions,under
R441 T521 T525 nsubj inhibition,be
R442 T522 T521 prep of,inhibition
R443 T523 T522 pobj A20,of
R444 T524 T525 aux might,be
R445 T525 T516 ccomp be,suggest
R446 T526 T525 prep of,be
R447 T527 T526 pobj interest,of
R448 T528 T527 prep in,interest
R449 T529 T530 det the,management
R450 T530 T528 pobj management,in
R451 T531 T530 prep of,management
R452 T532 T533 compound IAV,infections
R453 T533 T531 pobj infections,of
R454 T534 T499 punct .,challenge
R485 T300 T302 nummod A20,Tnfaip3
R486 T301 T302 punct (,Tnfaip3
R487 T302 T304 nmod Tnfaip3,Deficiency
R488 T303 T302 punct ),Tnfaip3
R489 T304 T308 nsubj Deficiency,Protects
R490 T305 T304 prep in,Deficiency
R491 T306 T307 compound Myeloid,Cells
R492 T307 T305 pobj Cells,in
R493 T308 T308 ROOT Protects,Protects
R494 T309 T308 prep against,Protects
R495 T310 T311 compound Influenza,A
R496 T311 T318 dative A,provides
R1724 T2478 T2479 nsubj Viruses,are
R1736 T2479 T2479 ROOT are,are
R1739 T2480 T2481 det a,class
R1741 T2481 T2479 attr class,are
R1743 T2482 T2481 prep of,class
R1744 T2483 T2484 advmod highly,diverse
R1747 T2484 T2485 amod diverse,pathogens
R1749 T2485 T2482 pobj pathogens,of
R1750 T2486 T2487 nsubj which,depend
R1753 T2487 T2485 relcl depend,pathogens
R1760 T2488 T2487 prep on,depend
R1762 T2489 T2491 det the,cell
R1766 T2490 T2491 compound host,cell
R1772 T2491 T2488 pobj cell,on
R1775 T2492 T2491 prep for,cell
R1776 T2493 T2494 poss their,replication
R1777 T2494 T2492 pobj replication,for
R1778 T2495 T2479 punct .,are
R1779 T2496 T2497 det The,initiation
R1780 T2497 T2505 nsubj initiation,involves
R1781 T2546 T2539 conj type,TNF
R1782 T2498 T2497 prep of,initiation
R1783 T2547 T2548 nsubj I,interferons
R1784 T2548 T2536 parataxis interferons,cytokines
R1785 T2499 T2504 det a,response
R1786 T2549 T2552 punct (,IFN-α
R1787 T2550 T2552 amod interferon-α,IFN-α
R1788 T2500 T2501 amod protective,innate
R1789 T2551 T2552 punct (,IFN-α
R1790 T2501 T2504 amod innate,response
R1791 T2552 T2548 appos IFN-α,interferons
R1792 T2553 T2552 punct ),IFN-α
R1793 T2502 T2504 amod antiviral,response
R1794 T2554 T2548 cc and,interferons
R1795 T2555 T2548 conj IFN-β,interferons
R1796 T2556 T2548 punct ),interferons
R1797 T2503 T2504 amod immune,response
R1798 T2557 T2530 prep through,induces
R1799 T2558 T2557 pobj activation,through
R1800 T2504 T2498 pobj response,of
R1801 T2559 T2558 prep of,activation
R1802 T2560 T2562 amod downstream,pathways
R1803 T2561 T2562 compound signaling,pathways
R1804 T2505 T2505 ROOT involves,involves
R1805 T2562 T2559 pobj pathways,of
R1806 T2563 T2564 nsubj that,control
R1807 T2506 T2507 det the,action
R1808 T2564 T2562 relcl control,pathways
R1809 T2565 T2567 amod various,factors
R1810 T2507 T2505 dobj action,involves
R1811 T2566 T2567 compound transcription,factors
R1812 T2567 T2564 dobj factors,control
R1813 T2568 T2569 amod such,as
R1814 T2508 T2507 prep of,action
R1815 T2569 T2567 prep as,factors
R1816 T2570 T2569 pobj NF-κB,as
R1817 T2571 T2570 punct ",",NF-κB
R1818 T2572 T2570 conj AP-1,NF-κB
R1819 T2509 T2512 amod specialized,receptors
R1820 T2573 T2572 punct ",",AP-1
R1821 T2574 T2572 conj IRF3,AP-1
R1822 T2510 T2511 compound pattern,recognition
R1823 T2575 T2574 cc and,IRF3
R1824 T2576 T2577 compound IRF7,[
R1825 T2577 T2574 conj [,IRF3
R1826 T2578 T2579 nummod 1,]
R1827 T2511 T2512 compound recognition,receptors
R1828 T2579 T2577 conj ],[
R1829 T2580 T2579 punct ",",]
R1830 T2581 T2583 nmod [,]
R1831 T2582 T2583 nummod 2,]
R1832 T2583 T2579 conj ],]
R1833 T2584 T2530 punct .,induces
R1834 T2512 T2508 pobj receptors,of
R1835 T2585 T2586 det The,presence
R1836 T2586 T2609 nsubjpass presence,sensed
R1837 T2587 T2586 prep of,presence
R1838 T2513 T2512 punct (,receptors
R1839 T2588 T2590 amod viral,acids
R1840 T2589 T2590 amod nucleic,acids
R1841 T2590 T2587 pobj acids,of
R1842 T2514 T2512 appos PRR,receptors
R1843 T2591 T2590 punct ",",acids
R1844 T2592 T2593 amod such,as
R1845 T2593 T2590 prep as,acids
R1846 T2515 T2514 punct ),PRR
R1847 T2594 T2595 amod viral,RNA
R1848 T2595 T2593 pobj RNA,as
R1849 T2596 T2595 cc and,RNA
R1850 T2516 T2512 punct ",",receptors
R1851 T2597 T2595 conj DNA,RNA
R1852 T2598 T2597 punct ",",DNA
R1853 T2599 T2601 amod viral,intermediates
R1854 T2517 T2518 nsubj which,detect
R1855 T2600 T2601 compound replication,intermediates
R1856 T2601 T2597 conj intermediates,DNA
R1857 T2602 T2601 cc and,intermediates
R1858 T2518 T2512 relcl detect,receptors
R1859 T2603 T2604 amod viral,transcription
R1860 T2604 T2605 compound transcription,products
R1861 T2519 T2521 amod conserved,structures
R1862 T2605 T2601 conj products,intermediates
R1863 T2606 T2609 punct ",",sensed
R1864 T2607 T2609 aux can,sensed
R1865 T2520 T2521 amod molecular,structures
R1866 T2608 T2609 auxpass be,sensed
R1867 T2521 T2518 dobj structures,detect
R1868 T2522 T2521 prep of,structures
R1869 T2609 T2609 ROOT sensed,sensed
R1870 T2610 T2609 agent by,sensed
R1871 T2523 T2525 det the,pathogen
R1872 T2611 T2613 amod specific,PRRs
R1873 T2612 T2613 amod intracellular,PRRs
R1874 T2613 T2610 pobj PRRs,by
R1875 T2524 T2525 amod invading,pathogen
R1876 T2614 T2616 nmod [,]
R1877 T2615 T2616 nummod 3,]
R1878 T2616 T2609 npadvmod ],sensed
R1879 T2617 T2609 punct .,sensed
R1880 T2618 T2620 nmod Endosomal,receptors
R1881 T2619 T2620 amod Toll-like,receptors
R1882 T2525 T2522 pobj pathogen,of
R1883 T2620 T2639 nsubj receptors,detect
R1884 T2621 T2622 punct (,TLRs
R1885 T2622 T2620 appos TLRs,receptors
R1886 T2526 T2505 punct .,involves
R1887 T2623 T2622 punct ),TLRs
R1888 T2624 T2622 cc and,TLRs
R1889 T2625 T2629 nmod cytoplasmic,receptors
R1890 T2527 T2530 csubj Triggering,induces
R1891 T2626 T2627 compound RNA,helicase
R1892 T2627 T2629 nmod helicase,receptors
R1893 T2628 T2629 compound RIG-I-like,receptors
R1894 T2528 T2527 prep of,Triggering
R1895 T2629 T2622 conj receptors,TLRs
R1896 T2529 T2528 pobj PRRs,of
R1897 T2530 T2530 ROOT induces,induces
R1898 T2630 T2629 punct (,receptors
R1899 T2631 T2629 conj RLRs,receptors
R1900 T2632 T2629 punct ),receptors
R1901 T2531 T2532 det the,production
R1902 T2633 T2629 cc or,receptors
R1903 T2634 T2635 amod Nod-like,receptors
R1904 T2635 T2629 conj receptors,receptors
R1905 T2532 T2530 dobj production,induces
R1906 T2636 T2637 punct (,NLRs
R1907 T2637 T2635 appos NLRs,receptors
R1908 T2533 T2532 prep of,production
R1909 T2638 T2635 punct ),receptors
R1910 T2639 T2639 ROOT detect,detect
R1911 T2640 T2641 det the,presence
R1912 T2534 T2536 nmod host,cytokines
R1913 T2641 T2639 dobj presence,detect
R1914 T2642 T2641 prep of,presence
R1915 T2535 T2536 compound proinflammatory,cytokines
R1916 T2536 T2533 pobj cytokines,of
R1917 T2537 T2548 punct (,interferons
R1918 T2538 T2539 compound e.g.,TNF
R1919 T2643 T2645 amod viral,stranded
R1920 T2644 T2645 amod single,stranded
R1921 T2645 T2639 advcl stranded,detect
R1922 T2539 T2548 nmod TNF,interferons
R1923 T2646 T2645 punct (,stranded
R1924 T2647 T2645 appos TLR7,stranded
R1925 T2540 T2539 punct ",",TNF
R1926 T2648 T2647 punct ",",TLR7
R1927 T2649 T2647 appos TLR8,TLR7
R1928 T2650 T2645 punct ",",stranded
R1929 T2651 T2645 npadvmod Nod2,stranded
R1930 T2652 T2645 punct ),stranded
R1931 T2653 T2645 cc or,stranded
R1932 T2541 T2539 conj IL-6,TNF
R1933 T2654 T2655 advmod double,stranded
R1934 T2655 T2645 conj stranded,stranded
R1935 T2656 T2655 dobj RNA,stranded
R1936 T2542 T2541 cc and,IL-6
R1937 T2657 T2656 punct (,RNA
R1938 T2658 T2656 appos TLR3,RNA
R1939 T2659 T2656 punct ",",RNA
R1940 T2543 T2541 conj IL-1,IL-6
R1941 T2660 T2656 conj RIG-I,RNA
R1942 T2661 T2660 punct ",",RIG-I
R1943 T2544 T2543 punct ),IL-1
R1944 T2662 T2660 conj MDA5,RIG-I
R1945 T2663 T2655 punct ),stranded
R1946 T2664 T2645 punct .,stranded
R1947 T2545 T2539 cc and,TNF
R1948 T2665 T2666 compound Intracellular,DNA
R1949 T2666 T2667 compound DNA,sensors
R1950 T2740 T2739 cc and,macrophages
R1951 T2667 T2676 nsubj sensors,include
R1952 T2668 T2669 nsubj that,mediate
R1953 T2669 T2667 relcl mediate,sensors
R1954 T2670 T2672 amod antiviral,responses
R1955 T2671 T2672 amod immune,responses
R1956 T2741 T2739 conj fibroblasts,macrophages
R1957 T2672 T2669 dobj responses,mediate
R1958 T2673 T2672 prep to,responses
R1959 T2742 T2743 punct ",",depend
R1960 T2674 T2675 compound DNA,viruses
R1961 T2675 T2673 pobj viruses,to
R1962 T2676 T2676 ROOT include,include
R1963 T2743 T2712 advcl depend,restricted
R1964 T2677 T2676 dobj TLR9,include
R1965 T2678 T2677 punct ",",TLR9
R1966 T2744 T2743 prep on,depend
R1967 T2679 T2680 compound DAI,[
R1968 T2680 T2677 appos [,TLR9
R1969 T2681 T2682 nummod 4,]
R1970 T2745 T2747 det the,RNA
R1971 T2682 T2680 dobj ],[
R1972 T2683 T2682 cc and,]
R1973 T2684 T2686 det the,domain
R1974 T2746 T2747 compound cytosolic,RNA
R1975 T2685 T2686 compound PYHIN,domain
R1976 T2686 T2682 conj domain,]
R1977 T2687 T2686 acl containing,domain
R1978 T2747 T2744 pobj RNA,on
R1979 T2688 T2687 dobj proteins,containing
R1980 T2689 T2690 compound AIM2,[
R1981 T2690 T2692 nmod [,]
R1982 T2691 T2692 nummod 5,]
R1983 T2692 T2688 appos ],proteins
R1984 T2748 T2747 cc and,RNA
R1985 T2693 T2692 punct ",",]
R1986 T2694 T2696 compound [,]
R1987 T2695 T2696 compound 6,]
R1988 T2696 T2692 conj ],]
R1989 T2749 T2747 conj DNA,RNA
R1990 T2697 T2696 punct ",",]
R1991 T2698 T2696 conj [,]
R1992 T2750 T2743 dobj sensors,depend
R1993 T2699 T2700 nummod 7,]
R1994 T2700 T2698 dobj ],[
R1995 T2701 T2700 cc and,]
R1996 T2702 T2703 compound IFI16,[
R1997 T2751 T2743 prep for,depend
R1998 T2703 T2700 conj [,]
R1999 T2704 T2705 nummod 8,]
R2000 T2705 T2700 conj ],]
R2001 T2752 T2753 det the,production
R2002 T2706 T2676 punct .,include
R2003 T2707 T2708 nsubj TLR,mediated
R2004 T2753 T2751 pobj production,for
R2005 T2708 T2708 ROOT mediated,mediated
R2006 T2754 T2753 prep of,production
R2007 T2709 T2710 amod antiviral,responses
R2008 T2710 T2712 nsubjpass responses,restricted
R2009 T2755 T2756 amod antiviral,proteins
R2010 T2711 T2712 auxpass are,restricted
R2011 T2712 T2708 ccomp restricted,mediated
R2012 T2713 T2712 prep to,restricted
R2013 T2714 T2715 amod specialized,type
R2014 T2756 T2754 pobj proteins,of
R2015 T2715 T2713 pobj type,to
R2016 T2716 T2718 nsubj I,producing
R2017 T2757 T2743 conj [,depend
R2018 T2717 T2718 aux IFN,producing
R2019 T2718 T2715 relcl producing,type
R2020 T2758 T2759 nummod 9,]
R2021 T2719 T2721 amod plasmacytoid,cells
R2022 T2720 T2721 amod dendritic,cells
R2023 T2721 T2718 dobj cells,producing
R2024 T2759 T2757 dobj ],[
R2025 T2722 T2721 punct (,cells
R2026 T2723 T2721 appos pDC,cells
R2027 T2760 T2708 punct .,mediated
R2028 T2724 T2721 punct ),cells
R2029 T2725 T2718 punct ",",producing
R2030 T2726 T2743 mark while,depend
R2031 T2727 T2730 amod most,types
R2032 T2728 T2730 amod other,types
R2033 T2729 T2730 compound cell,types
R2034 T2730 T2743 nsubj types,depend
R2035 T2761 T2767 nsubj Influenza,is
R2036 T2731 T2730 punct ",",types
R2037 T2732 T2730 prep including,types
R2038 T2733 T2734 amod conventional,DC
R2039 T2762 T2763 det A,virus
R2040 T2734 T2732 pobj DC,including
R2041 T2735 T2736 punct (,cDC
R2042 T2736 T2730 appos cDC,types
R2043 T2763 T2761 appos virus,Influenza
R2044 T2737 T2736 punct ),cDC
R2045 T2738 T2736 punct ",",cDC
R2046 T2739 T2736 conj macrophages,cDC
R2047 T2764 T2765 punct (,IAV
R2048 T2765 T2763 appos IAV,virus
R2049 T2766 T2763 punct ),virus
R2050 T2767 T2767 ROOT is,is
R2051 T2768 T2770 det the,agent
R2052 T2837 T2836 prep in,exposure
R2053 T2769 T2770 amod etiological,agent
R2054 T2838 T2840 det the,cell
R2055 T2839 T2840 compound host,cell
R2056 T2770 T2767 attr agent,is
R2057 T2840 T2837 pobj cell,in
R2058 T2841 T2840 prep of,cell
R2059 T2842 T2844 amod single-stranded,RNA
R2060 T2771 T2770 prep of,agent
R2061 T2843 T2844 compound genomic,RNA
R2062 T2844 T2841 pobj RNA,of
R2063 T2772 T2776 det a,disease
R2064 T2845 T2836 cc and,exposure
R2065 T2773 T2776 amod contagious,disease
R2066 T2846 T2847 nsubj double,stranded
R2067 T2774 T2776 amod acute,disease
R2068 T2847 T2833 ccomp stranded,leads
R2069 T2848 T2847 dobj RNA,stranded
R2070 T2775 T2776 amod respiratory,disease
R2071 T2849 T2848 punct ",",RNA
R2072 T2850 T2851 det the,latter
R2073 T2851 T2852 nsubj latter,being
R2074 T2776 T2771 pobj disease,of
R2075 T2852 T2847 advcl being,stranded
R2076 T2853 T2854 det an,intermediate
R2077 T2777 T2778 nsubj that,causes
R2078 T2854 T2852 attr intermediate,being
R2079 T2855 T2854 prep of,intermediate
R2080 T2856 T2857 amod viral,replication
R2081 T2857 T2855 pobj replication,of
R2082 T2858 T2833 punct .,leads
R2083 T2778 T2776 relcl causes,disease
R2084 T2859 T2864 nsubjpass TLR3,implicated
R2085 T2860 T2859 cc and,TLR3
R2086 T2861 T2859 conj RIG-I,TLR3
R2087 T2779 T2780 amod considerable,mortality
R2088 T2862 T2864 aux have,implicated
R2089 T2863 T2864 auxpass been,implicated
R2090 T2864 T2864 ROOT implicated,implicated
R2091 T2780 T2778 dobj mortality,causes
R2092 T2865 T2864 prep as,implicated
R2093 T2866 T2865 pobj sensors,as
R2094 T2781 T2780 punct ",",mortality
R2095 T2782 T2785 nsubjpass which,believed
R2096 T2867 T2866 prep of,sensors
R2097 T2783 T2785 auxpass is,believed
R2098 T2784 T2785 advmod generally,believed
R2099 T2868 T2869 compound IAV,infection
R2100 T2869 T2867 pobj infection,of
R2101 T2870 T2872 nmod [,]
R2102 T2785 T2780 relcl believed,mortality
R2103 T2871 T2872 nummod 10,]
R2104 T2872 T2866 appos ],sensors
R2105 T2873 T2875 nmod [,]
R2106 T2786 T2787 aux to,be
R2107 T2874 T2875 nummod 12,]
R2108 T2875 T2872 appos ],]
R2109 T2787 T2785 xcomp be,believed
R2110 T2876 T2864 punct .,implicated
R2111 T2877 T2878 det Both,receptors
R2112 T2878 T2879 nsubj receptors,contribute
R2113 T2788 T2787 acomp due,be
R2114 T2879 T2879 ROOT contribute,contribute
R2115 T2880 T2879 prep to,contribute
R2116 T2881 T2883 det the,response
R2117 T2789 T2788 prep to,due
R2118 T2882 T2883 amod proinflammatory,response
R2119 T2883 T2880 pobj response,to
R2120 T2790 T2794 det an,response
R2121 T2884 T2883 prep to,response
R2122 T2885 T2884 pobj IAV,to
R2123 T2886 T2879 punct ",",contribute
R2124 T2791 T2794 amod excessive,response
R2125 T2887 T2879 cc but,contribute
R2126 T2888 T2889 det the,initiation
R2127 T2792 T2794 nmod host,response
R2128 T2889 T2897 nsubj initiation,depends
R2129 T2890 T2889 prep of,initiation
R2130 T2891 T2895 det the,response
R2131 T2892 T2895 amod innate,response
R2132 T2893 T2895 amod antiviral,response
R2133 T2894 T2895 amod immune,response
R2134 T2793 T2794 amod inflammatory,response
R2135 T2895 T2890 pobj response,of
R2136 T2896 T2897 advmod largely,depends
R2137 T2897 T2879 conj depends,contribute
R2138 T2794 T2789 pobj response,to
R2139 T2898 T2897 prep on,depends
R2140 T2899 T2900 nsubj RIG-I,mediated
R2141 T2900 T2879 conj mediated,contribute
R2142 T2795 T2767 punct .,is
R2143 T2901 T2900 xcomp signaling,mediated
R2144 T2902 T2904 nmod [,]
R2145 T2903 T2904 nummod 13,]
R2146 T2904 T2901 dobj ],signaling
R2147 T2796 T2806 nsubj Emergence,underscores
R2148 T2905 T2900 punct .,mediated
R2149 T2906 T2911 advmod Interestingly,are
R2150 T2907 T2911 punct ",",are
R2151 T2797 T2796 prep of,Emergence
R2152 T2908 T2910 nmod RIG-I,mice
R2153 T2909 T2910 amod deficient,mice
R2154 T2910 T2911 nsubj mice,are
R2155 T2798 T2799 amod drug-resistant,strains
R2156 T2911 T2911 ROOT are,are
R2157 T2912 T2913 advmod highly,susceptible
R2158 T2799 T2797 pobj strains,of
R2159 T2913 T2911 acomp susceptible,are
R2160 T2914 T2913 prep to,susceptible
R2161 T2915 T2916 compound IAV,[
R2162 T2916 T2914 pobj [,to
R2163 T2800 T2799 prep of,strains
R2164 T2917 T2918 nummod 14,]
R2165 T2918 T2916 appos ],[
R2166 T2801 T2802 compound influenza,viruses
R2167 T2919 T2918 punct ",",]
R2168 T2920 T2922 nmod [,]
R2169 T2921 T2922 nummod 15,]
R2170 T2922 T2916 conj ],[
R2171 T2802 T2800 pobj viruses,of
R2172 T2923 T2911 punct ",",are
R2173 T2924 T2928 mark whereas,have
R2174 T2803 T2799 prep with,strains
R2175 T2925 T2927 nummod TLR3,mice
R2176 T2926 T2927 amod deficient,mice
R2177 T2927 T2928 nsubj mice,have
R2178 T2928 T2911 advcl have,are
R2179 T2804 T2805 amod pandemic,potential
R2180 T2929 T2931 det a,advantage
R2181 T2930 T2931 compound survival,advantage
R2182 T2931 T2928 dobj advantage,have
R2183 T2932 T2931 prep to,advantage
R2184 T2933 T2934 amod acute,infection
R2185 T2805 T2803 pobj potential,with
R2186 T2806 T2806 ROOT underscores,underscores
R2187 T2807 T2808 det the,importance
R2188 T2934 T2932 pobj infection,to
R2189 T2935 T2932 pobj [,to
R2190 T2808 T2806 dobj importance,underscores
R2191 T2936 T2937 nummod 16,]
R2192 T2937 T2935 dobj ],[
R2193 T2938 T2911 punct .,are
R2194 T2809 T2808 prep of,importance
R2195 T2939 T2940 det These,results
R2196 T2940 T2941 nsubj results,indicate
R2197 T2941 T2941 ROOT indicate,indicate
R2198 T2810 T2809 pcomp developing,of
R2199 T2942 T2957 mark that,is
R2200 T2943 T2944 det an,imbalance
R2201 T2944 T2957 nsubj imbalance,is
R2202 T2811 T2813 amod novel,strategies
R2203 T2945 T2944 prep between,imbalance
R2204 T2946 T2950 det the,effects
R2205 T2812 T2813 amod antiviral,strategies
R2206 T2947 T2950 amod beneficial,effects
R2207 T2813 T2810 dobj strategies,developing
R2208 T2814 T2806 punct .,underscores
R2209 T2948 T2947 cc and,beneficial
R2210 T2815 T2828 prep In,is
R2211 T2949 T2947 conj harmful,beneficial
R2212 T2950 T2945 pobj effects,between
R2213 T2816 T2817 det this,context
R2214 T2951 T2950 prep of,effects
R2215 T2952 T2951 pobj mediators,of
R2216 T2953 T2950 acl released,effects
R2217 T2817 T2815 pobj context,In
R2218 T2954 T2953 agent by,released
R2219 T2955 T2956 amod immune,cells
R2220 T2956 T2954 pobj cells,by
R2221 T2818 T2828 punct ",",is
R2222 T2957 T2941 ccomp is,indicate
R2223 T2958 T2957 acomp likely,is
R2224 T2819 T2828 nsubj understanding,is
R2225 T2959 T2960 aux to,contribute
R2226 T2960 T2958 xcomp contribute,likely
R2227 T2961 T2960 prep to,contribute
R2228 T2820 T2819 prep of,understanding
R2229 T2962 T2963 det the,pathogenesis
R2230 T2963 T2961 pobj pathogenesis,to
R2231 T2964 T2963 prep of,pathogenesis
R2232 T2965 T2964 pobj influenza,of
R2233 T2966 T2941 punct .,indicate
R2234 T2967 T2968 nsubj RIG-I,contains
R2235 T2821 T2822 det the,mechanisms
R2236 T2968 T2968 ROOT contains,contains
R2237 T2969 T2974 det a,domain
R2238 T2970 T2972 amod C-terminal,box
R2239 T2822 T2820 pobj mechanisms,of
R2240 T2971 T2972 compound DExD/H,box
R2241 T2972 T2974 compound box,domain
R2242 T2973 T2974 compound helicase,domain
R2243 T2974 T2968 dobj domain,contains
R2244 T2823 T2824 nsubj that,regulate
R2245 T2824 T2822 relcl regulate,mechanisms
R2246 T2975 T2974 punct ",",domain
R2247 T2825 T2827 amod IAV-induced,responses
R2248 T2976 T2978 nsubjpass which,required
R2249 T2977 T2978 auxpass is,required
R2250 T2978 T2974 relcl required,domain
R2251 T2826 T2827 amod immune,responses
R2252 T2979 T2978 prep for,required
R2253 T2980 T2981 compound ligand,recognition
R2254 T2981 T2979 pobj recognition,for
R2255 T2827 T2824 dobj responses,regulate
R2256 T2982 T2974 punct ",",domain
R2257 T2983 T2974 cc and,domain
R2258 T2984 T2987 nummod two,domains
R2259 T2828 T2828 ROOT is,is
R2260 T2985 T2986 compound N-terminal,CARD
R2261 T2986 T2987 compound CARD,domains
R2262 T2987 T2974 conj domains,domain
R2263 T2988 T2968 punct .,contains
R2264 T2829 T2828 acomp critical,is
R2265 T2989 T2989 ROOT Upon,Upon
R2266 T2990 T2991 compound ligand,binding
R2267 T2991 T2989 pobj binding,Upon
R2268 T2830 T2828 punct .,is
R2269 T2992 T2995 punct ",",domains
R2270 T2993 T2995 det the,domains
R2271 T2994 T2995 compound CARD,domains
R2272 T2831 T2832 compound IAV,infection
R2273 T2995 T2991 conj domains,binding
R2274 T2996 T2995 prep of,domains
R2275 T2997 T2998 compound RIG-I,associate
R2276 T2832 T2833 nsubj infection,leads
R2277 T2998 T2996 pobj associate,of
R2278 T2999 T2998 prep with,associate
R2279 T3000 T3002 det the,domain
R2280 T2833 T2833 ROOT leads,leads
R2281 T3001 T3002 compound CARD,domain
R2282 T3002 T2999 pobj domain,with
R2283 T3003 T3002 prep of,domain
R2284 T3004 T3005 det the,MAVS
R2285 T3005 T3003 pobj MAVS,of
R2286 T3006 T3008 punct (,termed
R2287 T2834 T2833 prep to,leads
R2288 T3007 T3008 advmod also,termed
R2289 T3008 T3005 parataxis termed,MAVS
R2290 T3009 T3008 oprd IPS-1,termed
R2291 T2835 T2836 det the,exposure
R2292 T3010 T3009 punct ",",IPS-1
R2293 T3011 T3016 nmod VISA,protein
R2294 T3012 T3011 punct ",",VISA
R2295 T2836 T2834 pobj exposure,to
R2296 T3013 T3011 appos Cardif,VISA
R2297 T3014 T3016 punct ),protein
R2298 T3015 T3016 compound adaptor,protein
R2299 T3031 T3033 amod C-terminal,domain
R2300 T3016 T3009 appos protein,IPS-1
R2301 T3017 T3016 punct ",",protein
R2302 T3018 T3020 nsubj which,translocates
R2303 T3019 T3020 advmod subsequently,translocates
R2304 T3020 T3016 relcl translocates,protein
R2305 T3021 T3020 prep to,translocates
R2306 T3032 T3033 compound transmembrane,domain
R2307 T3022 T3020 cc and,translocates
R2308 T3023 T3020 conj inserts,translocates
R2309 T3024 T3023 prep in,inserts
R2310 T3033 T3029 pobj domain,via
R2311 T3025 T3028 det the,membrane
R2312 T3034 T3036 nmod [,]
R2313 T3026 T3028 amod outer,membrane
R2314 T3035 T3036 nummod 17,]
R2315 T3027 T3028 amod mitochondrial,membrane
R2316 T3028 T3024 pobj membrane,in
R2317 T3029 T3023 prep via,inserts
R2318 T3036 T3023 conj ],inserts
R2319 T3030 T3033 poss its,domain
R2320 T3037 T3036 appos [,]
R2321 T3038 T3039 nummod 20,]
R2322 T3039 T3036 conj ],]
R2323 T3128 T3122 prep upon,mediate
R2324 T3040 T2989 punct .,Upon
R2325 T3129 T3130 compound RIG-I,stimulation
R2326 T3130 T3128 pobj stimulation,upon
R2327 T3131 T3104 punct .,characterized
R2328 T3041 T3045 csubj Signaling,requires
R2329 T3132 T3165 prep On,shown
R2330 T3133 T3135 det the,hand
R2331 T3042 T3041 advmod downstream,Signaling
R2332 T3134 T3135 amod other,hand
R2333 T3135 T3132 pobj hand,On
R2334 T3136 T3165 punct ",",shown
R2335 T3137 T3165 advcl deubiquitinating,shown
R2336 T3138 T3137 dobj enzymes,deubiquitinating
R2337 T3139 T3138 punct (,enzymes
R2338 T3043 T3042 prep of,downstream
R2339 T3140 T3138 appos DUBs,enzymes
R2340 T3141 T3138 punct ),enzymes
R2341 T3142 T3138 punct ",",enzymes
R2342 T3044 T3043 pobj MAVS,of
R2343 T3143 T3144 amod such,as
R2344 T3144 T3138 prep as,enzymes
R2345 T3145 T3146 compound DUBA,[
R2346 T3045 T3045 ROOT requires,requires
R2347 T3146 T3144 pobj [,as
R2348 T3147 T3148 nummod 28,]
R2349 T3046 T3047 det the,action
R2350 T3148 T3146 conj ],[
R2351 T3149 T3148 punct ",",]
R2352 T3150 T3151 compound CYLD,[
R2353 T3047 T3045 dobj action,requires
R2354 T3151 T3148 conj [,]
R2355 T3152 T3153 compound 29,]
R2356 T3153 T3151 conj ],[
R2357 T3048 T3047 prep of,action
R2358 T3154 T3153 punct ",",]
R2359 T3155 T3153 conj [,]
R2360 T3156 T3157 nummod 30,]
R2361 T3049 T3052 amod various,enzymes
R2362 T3157 T3153 conj ],]
R2363 T3158 T3157 cc and,]
R2364 T3159 T3160 compound OTUB1/2,[
R2365 T3050 T3051 compound ubiquitin,modifying
R2366 T3160 T3157 conj [,]
R2367 T3161 T3162 nummod 31,]
R2368 T3162 T3157 conj ],]
R2369 T3051 T3052 amod modifying,enzymes
R2370 T3163 T3165 aux have,shown
R2371 T3164 T3165 auxpass been,shown
R2372 T3165 T3165 ROOT shown,shown
R2373 T3052 T3048 pobj enzymes,of
R2374 T3166 T3168 aux to,regulate
R2375 T3167 T3168 advmod negatively,regulate
R2376 T3053 T3052 punct ",",enzymes
R2377 T3168 T3165 xcomp regulate,shown
R2378 T3169 T3168 dobj RLR,regulate
R2379 T3170 T3165 advcl signaling,shown
R2380 T3054 T3059 nsubj which,regulate
R2381 T3171 T3170 prep by,signaling
R2382 T3172 T3173 advmod specifically,removing
R2383 T3173 T3171 pcomp removing,by
R2384 T3174 T3176 amod K63-linked,chains
R2385 T3175 T3176 compound polyubiquitin,chains
R2386 T3176 T3173 dobj chains,removing
R2387 T3055 T3056 preconj both,positively
R2388 T3177 T3173 prep from,removing
R2389 T3178 T3180 amod several,molecules
R2390 T3179 T3180 amod signaling,molecules
R2391 T3056 T3059 advmod positively,regulate
R2392 T3180 T3177 pobj molecules,from
R2393 T3181 T3165 punct .,shown
R2394 T3057 T3056 cc and,positively
R2395 T3058 T3056 conj negatively,positively
R2396 T3182 T3211 advmod Furthermore,inhibiting
R2397 T3059 T3052 relcl regulate,enzymes
R2398 T3183 T3211 punct ",",inhibiting
R2399 T3184 T3187 amod various,ligases
R2400 T3185 T3187 amod K48-specific,ligases
R2401 T3186 T3187 compound ubiquitin,ligases
R2402 T3060 T3059 dobj RIG-I,regulate
R2403 T3187 T3211 nsubj ligases,inhibiting
R2404 T3188 T3187 punct ",",ligases
R2405 T3189 T3190 amod such,as
R2406 T3061 T3063 amod mediated,transduction
R2407 T3190 T3187 prep as,ligases
R2408 T3191 T3192 compound AIP4,[
R2409 T3062 T3063 compound signal,transduction
R2410 T3192 T3190 pobj [,as
R2411 T3193 T3194 nummod 32,]
R2412 T3194 T3192 conj ],[
R2413 T3063 T3064 compound transduction,[
R2414 T3195 T3194 cc and,]
R2415 T3196 T3197 compound TRIAD3A,[
R2416 T3197 T3194 conj [,]
R2417 T3064 T3045 dobj [,requires
R2418 T3198 T3199 nummod 33,]
R2419 T3199 T3200 compound ],mark
R2420 T3200 T3192 conj mark,[
R2421 T3065 T3066 nummod 21,]
R2422 T3201 T3202 advmod respectively,MAVS
R2423 T3202 T3200 dobj MAVS,mark
R2424 T3203 T3202 cc and,MAVS
R2425 T3066 T3064 appos ],[
R2426 T3204 T3202 conj TRAF3,MAVS
R2427 T3205 T3200 prep for,mark
R2428 T3067 T3045 punct .,requires
R2429 T3206 T3208 amod proteasome,degradation
R2430 T3207 T3208 amod mediated,degradation
R2431 T3208 T3205 pobj degradation,for
R2432 T3209 T3187 punct ",",ligases
R2433 T3210 T3211 advmod thus,inhibiting
R2434 T3211 T3211 ROOT inhibiting,inhibiting
R2435 T3068 T3070 nmod K63-specific,ligases
R2436 T3212 T3213 advmod further,downstream
R2437 T3213 T3214 amod downstream,signaling
R2438 T3214 T3211 dobj signaling,inhibiting
R2439 T3215 T3211 punct .,inhibiting
R2440 T3069 T3070 compound ubiquitin,ligases
R2441 T3216 T3219 advmod Additionally,attachment
R2442 T3217 T3219 punct ",",attachment
R2443 T3218 T3219 det the,attachment
R2444 T3070 T3093 nsubjpass ligases,shown
R2445 T3219 T3219 ROOT attachment,attachment
R2446 T3220 T3219 prep of,attachment
R2447 T3221 T3223 amod K48-specific,chains
R2448 T3071 T3072 punct (,E3s
R2449 T3222 T3223 compound polyubiquitin,chains
R2450 T3223 T3220 pobj chains,of
R2451 T3224 T3219 prep to,attachment
R2452 T3072 T3070 appos E3s,ligases
R2453 T3073 T3070 punct ),ligases
R2454 T3074 T3070 punct ",",ligases
R2455 T3225 T3226 det the,IRF3
R2456 T3075 T3076 amod such,as
R2457 T3226 T3224 pobj IRF3,to
R2458 T3227 T3226 cc and,IRF3
R2459 T3076 T3070 prep as,ligases
R2460 T3228 T3226 conj IRF7,IRF3
R2461 T3229 T3230 compound transcription,factors
R2462 T3230 T3219 conj factors,attachment
R2463 T3077 T3080 nummod TRIM25,]
R2464 T3231 T3219 prep by,attachment
R2465 T3232 T3231 pobj E3s,by
R2466 T3233 T3234 amod such,as
R2467 T3078 T3080 nmod [,]
R2468 T3234 T3232 prep as,E3s
R2469 T3235 T3236 compound RAUL,[
R2470 T3079 T3080 nummod 22,]
R2471 T3236 T3234 pobj [,as
R2472 T3237 T3238 nummod 34,]
R2473 T3238 T3236 conj ],[
R2474 T3080 T3076 pobj ],as
R2475 T3239 T3238 punct ",",]
R2476 T3240 T3243 nummod TRIM21,]
R2477 T3081 T3080 cc and,]
R2478 T3241 T3243 nmod [,]
R2479 T3242 T3243 nummod 35,]
R2480 T3243 T3238 conj ],]
R2481 T3082 T3083 compound Riplet,[
R2482 T3244 T3243 cc and,]
R2483 T3245 T3246 compound RBCK1,[
R2484 T3246 T3243 conj [,]
R2485 T3247 T3248 nummod 36,]
R2486 T3248 T3253 nmod ],transduction
R2487 T3249 T3253 amod further,transduction
R2488 T3083 T3080 conj [,]
R2489 T3250 T3253 amod dampens,transduction
R2490 T3251 T3253 amod antiviral,transduction
R2491 T3252 T3253 compound signal,transduction
R2492 T3084 T3085 nummod 23,]
R2493 T3253 T3236 appos transduction,[
R2494 T3254 T3219 punct .,attachment
R2495 T3085 T3083 conj ],[
R2496 T3255 T3256 nsubj A20,is
R2497 T3256 T3256 ROOT is,is
R2498 T3257 T3259 det an,enzyme
R2499 T3258 T3259 amod ubiquitin-editing,enzyme
R2500 T3086 T3085 punct ",",]
R2501 T3259 T3256 attr enzyme,is
R2502 T3260 T3259 acl belonging,enzyme
R2503 T3087 T3089 nmod [,]
R2504 T3088 T3089 nummod 24,]
R2505 T3261 T3260 prep to,belonging
R2506 T3262 T3264 det the,family
R2507 T3089 T3085 conj ],]
R2508 T3263 T3264 compound OTU-domain,family
R2509 T3264 T3261 pobj family,to
R2510 T3265 T3264 prep of,family
R2511 T3090 T3093 punct ",",shown
R2512 T3266 T3265 pobj DUBs,of
R2513 T3267 T3256 punct .,is
R2514 T3268 T3272 advmod Interestingly,harbors
R2515 T3091 T3093 aux have,shown
R2516 T3269 T3272 punct ",",harbors
R2517 T3092 T3093 auxpass been,shown
R2518 T3270 T3272 nsubj A20,harbors
R2519 T3271 T3272 advmod also,harbors
R2520 T3272 T3272 ROOT harbors,harbors
R2521 T3093 T3093 ROOT shown,shown
R2522 T3273 T3275 amod atypical,finger
R2523 T3274 T3275 compound zinc,finger
R2524 T3275 T3281 nmod finger,activity
R2525 T3094 T3096 aux to,promote
R2526 T3276 T3281 amod dependent,activity
R2527 T3277 T3281 amod K48-specific,activity
R2528 T3278 T3281 nmod E3,activity
R2529 T3095 T3096 advmod directly,promote
R2530 T3279 T3281 compound ubiquitin,activity
R2531 T3280 T3281 compound ligase,activity
R2532 T3281 T3272 dobj activity,harbors
R2533 T3096 T3093 xcomp promote,shown
R2534 T3282 T3272 punct .,harbors
R2535 T3283 T3287 det Both,mechanisms
R2536 T3284 T3287 amod catalytic,mechanisms
R2537 T3285 T3284 cc and,catalytic
R2538 T3286 T3284 conj noncatalytic,catalytic
R2539 T3287 T3290 nsubjpass mechanisms,shown
R2540 T3097 T3098 compound RIG-I,activation
R2541 T3288 T3290 auxpass were,shown
R2542 T3289 T3290 advmod previously,shown
R2543 T3290 T3290 ROOT shown,shown
R2544 T3098 T3096 dobj activation,promote
R2545 T3291 T3293 aux to,involved
R2546 T3292 T3293 auxpass be,involved
R2547 T3099 T3093 punct .,shown
R2548 T3293 T3290 xcomp involved,shown
R2549 T3294 T3293 prep in,involved
R2550 T3295 T3297 det the,regulation
R2551 T3296 T3297 amod negative,regulation
R2552 T3100 T3104 prep In,characterized
R2553 T3297 T3294 pobj regulation,in
R2554 T3298 T3297 prep of,regulation
R2555 T3101 T3100 pobj addition,In
R2556 T3299 T3298 pobj proinflammatory,of
R2557 T3300 T3297 acl signaling,regulation
R2558 T3301 T3300 prep by,signaling
R2559 T3102 T3104 punct ",",characterized
R2560 T3302 T3301 pobj A20,by
R2561 T3303 T3300 prep in,signaling
R2562 T3304 T3303 pobj response,in
R2563 T3103 T3104 advmod well,characterized
R2564 T3305 T3304 prep to,response
R2565 T3306 T3307 amod multiple,receptors
R2566 T3307 T3305 pobj receptors,to
R2567 T3104 T3104 ROOT characterized,characterized
R2568 T3308 T3309 amod such,as
R2569 T3309 T3307 prep as,receptors
R2570 T3310 T3311 compound TNF,receptor
R2571 T3105 T3106 compound ubiquitin,ligases
R2572 T3311 T3309 pobj receptor,as
R2573 T3312 T3313 nsubj I,[
R2574 T3313 T3315 nmod [,]
R2575 T3106 T3104 dobj ligases,characterized
R2576 T3314 T3315 nummod 37,]
R2577 T3315 T3315 ROOT ],]
R2578 T3107 T3108 amod such,as
R2579 T3316 T3315 appos [,]
R2580 T3317 T3318 nummod 39,]
R2581 T3108 T3104 prep as,characterized
R2583 T3109 T3108 pobj TRAF6,as
R2587 T3110 T3112 nmod [,]
R2588 T3111 T3112 nummod 25,]
R2591 T3112 T3122 nsubj ],mediate
R2594 T3113 T3112 punct ",",]
R2598 T3114 T3112 conj [,]
R2602 T3115 T3116 nummod 26,]
R2605 T3116 T3112 conj ],]
R2610 T3117 T3116 cc and,]
R2613 T3118 T3119 compound TRAF3,[
R2614 T3119 T3116 conj [,]
R2616 T3120 T3121 nummod 27,]
R2617 T3121 T3122 npadvmod ],mediate
R2618 T3122 T3104 advcl mediate,characterized
R2621 T3123 T3124 advmod respectively,NF-κB
R2624 T3124 T3127 amod NF-κB,activation
R2628 T3125 T3124 cc and,NF-κB
R2632 T3126 T3124 conj IRF3,NF-κB
R2638 T3127 T3122 dobj activation,mediate
R2649 T3364 T3365 compound gene,targeting
R2650 T3365 T3365 ROOT targeting,targeting
R2651 T3366 T3365 prep of,targeting
R2652 T3367 T3366 pobj A20,of
R2653 T3421 T3422 compound A20,locus
R2654 T3368 T3365 prep in,targeting
R2655 T3369 T3371 amod specific,types
R2656 T3370 T3371 compound cell,types
R2657 T3422 T3419 pobj locus,in
R2658 T3371 T3368 pobj types,in
R2659 T3372 T3373 auxpass was,shown
R2660 T3373 T3365 conj shown,targeting
R2661 T3423 T3425 nsubjpass that,associated
R2662 T3374 T3376 aux to,associated
R2663 T3375 T3376 auxpass be,associated
R2664 T3424 T3425 auxpass are,associated
R2665 T3376 T3373 xcomp associated,shown
R2666 T3377 T3376 prep with,associated
R2667 T3378 T3384 nmod autoimmunity,]
R2668 T3425 T3416 relcl associated,identification
R2669 T3379 T3378 cc and,autoimmunity
R2670 T3380 T3381 amod chronic,inflammation
R2671 T3381 T3378 conj inflammation,autoimmunity
R2672 T3426 T3425 prep with,associated
R2673 T3382 T3378 conj [,autoimmunity
R2674 T3383 T3384 nummod 42,]
R2675 T3384 T3377 pobj ],with
R2676 T3427 T3429 amod several,diseases
R2677 T3385 T3384 appos [,]
R2678 T3386 T3387 nummod 48,]
R2679 T3387 T3384 conj ],]
R2680 T3428 T3429 amod autoimmune,diseases
R2681 T3388 T3373 punct ",",shown
R2682 T3389 T3390 advmod further,illustrating
R2683 T3390 T3373 advcl illustrating,shown
R2684 T3429 T3426 pobj diseases,with
R2685 T3391 T3393 mark that,is
R2686 T3392 T3393 nsubj A20,is
R2687 T3393 T3390 ccomp is,illustrating
R2688 T3394 T3396 det an,brake
R2689 T3395 T3396 amod important,brake
R2690 T3396 T3393 attr brake,is
R2691 T3430 T3429 cc and,diseases
R2692 T3431 T3432 amod chronic,inflammation
R2694 T3432 T3429 conj inflammation,diseases
R2698 T3433 T3435 nmod [,]
R2702 T3434 T3435 nummod 45,]
R2705 T3435 T3432 appos ],inflammation
R2709 T3436 T3413 punct .,illustrated
R2713 T3437 T3462 prep In,is
R2717 T3438 T3437 pobj contrast,In
R2721 T3439 T3438 prep to,contrast
R2723 T3440 T3443 poss its,function
R2724 T3441 T3442 advmod well,established
R2725 T3442 T3443 amod established,function
R2726 T3516 T3514 pobj response,in
R2727 T3443 T3439 pobj function,to
R2728 T3517 T3516 prep to,response
R2729 T3518 T3519 amod viral,infection
R2730 T3519 T3517 pobj infection,to
R2731 T3444 T3443 prep in,function
R2732 T3520 T3520 ROOT remains,remains
R2733 T3521 T3523 aux to,clarified
R2734 T3445 T3446 det the,regulation
R2735 T3522 T3523 auxpass be,clarified
R2736 T3523 T3520 xcomp clarified,remains
R2737 T3524 T3520 punct .,remains
R2738 T3525 T3552 advcl Using,provide
R2739 T3526 T3527 amod myeloid,cell
R2740 T3446 T3444 pobj regulation,in
R2741 T3527 T3531 nmod cell,mice
R2742 T3528 T3531 amod specific,mice
R2743 T3529 T3531 compound A20,mice
R2744 T3530 T3531 compound knockout,mice
R2745 T3447 T3446 prep of,regulation
R2746 T3531 T3525 dobj mice,Using
R2747 T3532 T3531 punct (,mice
R2748 T3533 T3531 appos A20myel-KO,mice
R2749 T3448 T3449 amod proinflammatory,responses
R2750 T3534 T3531 punct ),mice
R2751 T3535 T3538 nsubjpass that,generated
R2752 T3449 T3447 pobj responses,of
R2753 T3536 T3538 auxpass were,generated
R2754 T3537 T3538 advmod recently,generated
R2755 T3538 T3525 relcl generated,Using
R2756 T3450 T3443 punct ",",function
R2757 T3539 T3538 prep in,generated
R2758 T3540 T3541 poss our,lab
R2759 T3541 T3539 pobj lab,in
R2760 T3451 T3452 det the,role
R2761 T3542 T3541 cc and,lab
R2762 T3543 T3544 amod primary,cells
R2763 T3544 T3541 conj cells,lab
R2764 T3545 T3544 acl derived,cells
R2765 T3452 T3462 nsubj role,is
R2766 T3546 T3545 prep of,derived
R2767 T3547 T3548 det these,mice
R2768 T3548 T3546 pobj mice,of
R2769 T3453 T3452 prep of,role
R2770 T3549 T3552 punct ",",provide
R2771 T3550 T3552 nsubj we,provide
R2772 T3454 T3453 pobj A20,of
R2773 T3551 T3552 advmod here,provide
R2774 T3552 T3552 ROOT provide,provide
R2775 T3553 T3552 dobj evidence,provide
R2776 T3455 T3452 prep in,role
R2777 T3554 T3556 mark that,is
R2778 T3555 T3556 nsubj A20,is
R2779 T3556 T3553 acl is,evidence
R2780 T3557 T3560 det a,regulator
R2781 T3456 T3457 det the,regulation
R2782 T3558 T3560 amod crucial,regulator
R2783 T3559 T3560 amod negative,regulator
R2784 T3560 T3556 attr regulator,is
R2785 T3457 T3455 pobj regulation,in
R2786 T3561 T3560 prep of,regulator
R2787 T3562 T3566 amod IAV-induced,signaling
R2788 T3563 T3566 amod proinflammatory,signaling
R2789 T3564 T3563 cc and,proinflammatory
R2790 T3565 T3563 conj antiviral,proinflammatory
R2791 T3566 T3561 pobj signaling,of
R2792 T3458 T3457 prep of,regulation
R2793 T3567 T3566 prep in,signaling
R2794 T3568 T3567 pobj macrophages,in
R2795 T3569 T3552 punct .,provide
R2796 T3570 T3574 advmod Interestingly,show
R2797 T3459 T3461 amod antiviral,responses
R2798 T3571 T3574 punct ",",show
R2799 T3572 T3573 amod A20myel-KO,mice
R2800 T3460 T3461 amod immune,responses
R2801 T3573 T3574 nsubj mice,show
R2802 T3574 T3574 ROOT show,show
R2803 T3575 T3576 amod enhanced,survival
R2804 T3461 T3458 pobj responses,of
R2805 T3576 T3574 dobj survival,show
R2806 T3577 T3574 cc and,show
R2807 T3578 T3574 conj reduced,show
R2808 T3462 T3462 ROOT is,is
R2809 T3463 T3465 advmod less,described
R2810 T3579 T3578 dobj morbidity,reduced
R2811 T3580 T3578 prep in,reduced
R2812 T3464 T3465 advmod well,described
R2813 T3581 T3580 pobj response,in
R2814 T3582 T3581 prep to,response
R2815 T3583 T3585 compound IAV,infection
R2816 T3465 T3462 acomp described,is
R2817 T3584 T3585 compound lung,infection
R2818 T3585 T3582 pobj infection,to
R2819 T3586 T3578 prep compared,reduced
R2820 T3466 T3465 cc and,described
R2821 T3587 T3586 prep to,compared
R2822 T3588 T3590 amod wild,mice
R2823 T3467 T3465 conj limited,described
R2824 T3589 T3590 compound type,mice
R2825 T3590 T3587 pobj mice,to
R2826 T3591 T3574 punct .,show
R2827 T3468 T3467 prep to,limited
R2828 T3592 T3599 nsubjpass Protection,associated
R2829 T3593 T3592 prep against,Protection
R2830 T3469 T3470 det a,number
R2831 T3594 T3593 pobj IAV,against
R2832 T3595 T3594 prep in,IAV
R2833 T3596 T3597 compound A20myel-KO,mice
R2834 T3597 T3595 pobj mice,in
R2835 T3470 T3468 pobj number,to
R2836 T3598 T3599 auxpass is,associated
R2837 T3599 T3599 ROOT associated,associated
R2838 T3600 T3599 prep with,associated
R2839 T3601 T3602 amod increased,cytokine
R2840 T3602 T3600 pobj cytokine,with
R2841 T3603 T3602 cc and,cytokine
R2842 T3471 T3470 prep of,number
R2843 T3604 T3605 compound chemokine,production
R2844 T3605 T3602 conj production,cytokine
R2845 T3606 T3605 punct ",",production
R2846 T3472 T3470 prep in,number
R2847 T3607 T3608 amod augmented,recruitment
R2848 T3608 T3602 conj recruitment,cytokine
R2849 T3609 T3608 prep of,recruitment
R2850 T3473 T3474 amod vitro,studies
R2851 T3610 T3612 amod innate,cells
R2852 T3611 T3612 amod immune,cells
R2853 T3474 T3472 pobj studies,in
R2854 T3612 T3609 pobj cells,of
R2855 T3475 T3467 advcl using,limited
R2856 T3476 T3475 dobj overexpression,using
R2857 T3613 T3614 amod such,as
R2858 T3614 T3612 prep as,cells
R2859 T3477 T3475 cc or,using
R2860 T3615 T3614 pobj neutophils,as
R2861 T3616 T3615 cc and,neutophils
R2862 T3617 T3618 amod alveolar,macrophages
R2863 T3478 T3475 conj silencing,using
R2864 T3618 T3615 conj macrophages,neutophils
R2865 T3619 T3618 punct ",",macrophages
R2866 T3620 T3618 cc and,macrophages
R2867 T3479 T3478 prep in,silencing
R2868 T3621 T3623 amod enhanced,clearance
R2869 T3622 T3623 amod viral,clearance
R2870 T3623 T3618 conj clearance,macrophages
R2871 T3480 T3482 amod specific,lines
R2872 T3624 T3599 punct .,associated
R2873 T3625 T3626 det These,results
R2874 T3481 T3482 compound cell,lines
R2875 T3626 T3627 nsubj results,suggest
R2876 T3627 T3627 ROOT suggest,suggest
R2877 T3628 T3644 mark that,have
R2878 T3482 T3479 pobj lines,in
R2879 T3629 T3644 csubj boosting,have
R2880 T3630 T3633 det the,response
R2881 T3483 T3462 punct ",",is
R2882 T3631 T3633 amod innate,response
R2883 T3632 T3633 amod immune,response
R2884 T3633 T3629 dobj response,boosting
R2885 T3484 T3462 advcl indicating,is
R2886 T3634 T3633 prep to,response
R2887 T3635 T3634 pobj IAV,to
R2888 T3636 T3629 prep by,boosting
R2889 T3637 T3636 pcomp targeting,by
R2890 T3638 T3639 amod A20,activity
R2891 T3639 T3637 dobj activity,targeting
R2892 T3485 T3488 mark that,regulate
R2893 T3640 T3637 prep in,targeting
R2894 T3641 T3642 amod myeloid,cells
R2895 T3642 T3640 pobj cells,in
R2896 T3486 T3488 nsubj A20,regulate
R2897 T3643 T3644 aux might,have
R2898 T3644 T3627 ccomp have,suggest
R2899 T3487 T3488 aux may,regulate
R2900 T3645 T3646 amod therapeutic,potential
R2901 T3646 T3644 dobj potential,have
R2902 T3647 T3627 punct .,suggest
R2903 T3488 T3484 ccomp regulate,indicating
R2904 T3489 T3488 dobj RIG-I,regulate
R2905 T3490 T3489 punct -,RIG-I
R2906 T3491 T3489 cc and,RIG-I
R2907 T3492 T3493 amod TLR3-induced,signaling
R2908 T3493 T3488 dobj signaling,regulate
R2909 T3494 T3501 prep to,[
R2910 T3495 T3494 pobj NF-κB,to
R2911 T3496 T3495 cc and,NF-κB
R2912 T3497 T3498 compound IRF-3,[
R2913 T3498 T3495 conj [,NF-κB
R2914 T3499 T3500 nummod 49,]
R2915 T3500 T3501 nmod ],[
R2916 T3501 T3488 xcomp [,regulate
R2917 T3502 T3503 nummod 52,]
R2918 T3503 T3501 dobj ],[
R2919 T3504 T3462 punct .,is
R2920 T3505 T3520 advmod However,remains
R2921 T3506 T3520 punct ",",remains
R2922 T3507 T3508 det the,precise
R2923 T3508 T3520 nsubj precise,remains
R2924 T3509 T3508 prep in,precise
R2925 T3510 T3511 compound vivo,role
R2926 T3511 T3509 pobj role,in
R2927 T3512 T3511 prep of,role
R2928 T3513 T3512 pobj A20,of
R2929 T3514 T3511 prep in,role
R2930 T3515 T3516 det the,response
R4107 T5848 T5849 nummod A20,inhibits
R4108 T5849 T5849 ROOT inhibits,inhibits
R4109 T5850 T5851 compound RIG-I-induced,NF-κB
R4110 T5851 T5849 dobj NF-κB,inhibits
R4111 T5852 T5851 cc and,NF-κB
R4112 T5853 T5854 amod IRF3,activation
R4113 T5854 T5851 conj activation,NF-κB
R4114 T5855 T5856 compound RIG-I,signaling
R4115 T5856 T5857 nsubj signaling,induces
R4116 T5857 T5857 ROOT induces,induces
R4117 T5858 T5859 det the,activation
R4118 T5859 T5857 dobj activation,induces
R4119 T5860 T5859 prep of,activation
R4120 T5861 T5860 pobj NF-κB,of
R4121 T5862 T5861 punct ",",NF-κB
R4122 T5863 T5861 conj IRF3,NF-κB
R4123 T5864 T5863 cc and,IRF3
R4124 T5865 T5863 conj IRF7,IRF3
R4125 T5866 T5867 compound transcription,factors
R4142 T5883 T5884 amod viral,propagation
R4143 T5884 T5881 dobj propagation,restrict
R4144 T5885 T5879 punct .,IFNs
R4145 T5886 T5887 amod Previous,studies
R4146 T5887 T5889 nsubj studies,shown
R4147 T5888 T5889 aux have,shown
R4148 T5889 T5889 ROOT shown,shown
R4149 T5890 T5892 mark that,expressed
R4150 T5891 T5892 nsubj ectopically,expressed
R4151 T5892 T5889 ccomp expressed,shown
R4152 T5893 T5892 dobj A20,expressed
R4153 T5894 T5895 advmod negatively,regulates
R4154 T5895 T5889 conj regulates,shown
R4155 T5896 T5895 dobj NF-κB,regulates
R4156 T5897 T5896 cc and,NF-κB
R4157 T5898 T5896 conj IRF3,NF-κB
R4158 T5899 T5896 conj activation,NF-κB
R4159 T5900 T5895 prep upon,regulates
R4160 T5901 T5902 compound RIG-I,stimulation
R4161 T5902 T5903 compound stimulation,[
R4162 T5903 T5906 ccomp [,[
R4163 T5904 T5905 nummod 50,]
R4164 T5905 T5906 nmod ],[
R4165 T5906 T5908 nmod [,]
R4166 T5907 T5908 nummod 52,]
R4167 T5908 T5895 dobj ],regulates
R4168 T5909 T5889 punct .,shown
R4169 T5910 T5913 advmod Similarly,show
R4170 T5911 T5913 punct ",",show
R4171 T5912 T5913 nsubj we,show
R4172 T5913 T5913 ROOT show,show
R4173 T5914 T5920 mark that,prevents
R4174 T5915 T5916 nummod A20,overexpression
R4175 T5916 T5920 nsubj overexpression,prevents
R4176 T5917 T5916 prep in,overexpression
R4177 T5918 T5919 nummod HEK293T,cells
R4178 T5919 T5917 pobj cells,in
R4179 T5920 T5913 ccomp prevents,show
R4180 T5921 T5920 dobj NF-κB,prevents
R4181 T5922 T5920 punct -,prevents
R4182 T5923 T5920 cc and,prevents
R4183 T5924 T5928 amod IRF3-dependent,activation
R4184 T5925 T5928 nmod luciferase,activation
R4185 T5926 T5928 compound reporter,activation
R4186 T5927 T5928 compound gene,activation
R4187 T5928 T5920 conj activation,prevents
R4188 T5929 T5928 acl induced,activation
R4211 T5960 T5962 punct (,1A
R4212 T5961 T5962 compound figure,1A
R4213 T5962 T5955 appos 1A,RIG-I
R4215 T5963 T5955 punct ",",RIG-I
R4216 T5964 T5967 amod left,graph
R4217 T5965 T5964 cc and,left
R4219 T5966 T5967 compound middle,graph
R4220 T5967 T5928 appos graph,activation
R4221 T5968 T5928 punct ),activation
R4223 T5969 T5913 punct .,show
R4224 T5970 T5972 nsubj We,investigated
R4225 T5971 T5972 advmod next,investigated
R4226 T5972 T5972 ROOT investigated,investigated
R4228 T5973 T5976 mark whether,inhibits
R4229 T5974 T5976 nsubj A20,inhibits
R4230 T5975 T5976 advmod also,inhibits
R4231 T5976 T5972 ccomp inhibits,investigated
R4232 T5977 T5978 compound IRF7,activation
R4233 T5978 T5976 dobj activation,inhibits
R4235 T5979 T5972 punct .,investigated
R4236 T5980 T5984 prep Unlike,is
R4237 T5981 T5980 pobj IRF3,Unlike
R4238 T5982 T5984 punct ",",is
R4240 T5983 T5984 nsubj IRF7,is
R4241 T5984 T5988 auxpass is,expressed
R4242 T5985 T5984 neg not,is
R4244 T5986 T5985 cc or,not
R4245 T5987 T5985 conj weakly,not
R4246 T5988 T5988 ROOT expressed,expressed
R4248 T5989 T5988 prep under,expressed
R4249 T5990 T5991 compound naïve,conditions
R4250 T5991 T5989 pobj conditions,under
R4251 T6042 T6046 det an,reporter
R4252 T5992 T5991 cc and,conditions
R4253 T6043 T6046 amod IRF7-specific,reporter
R4254 T5993 T5995 compound IRF7,levels
R4255 T5994 T5995 compound protein,levels
R4256 T5995 T5991 conj levels,conditions
R4257 T5996 T5998 auxpass are,upregulated
R4258 T6044 T6046 amod IFNα4,reporter
R4259 T5997 T5998 advmod rapidly,upregulated
R4260 T5998 T5988 advcl upregulated,expressed
R4261 T6045 T6046 compound luciferase,reporter
R4262 T5999 T5998 prep upon,upregulated
R4263 T6000 T6002 amod virus-induced,activation
R4264 T6001 T6002 amod IRF3,activation
R4265 T6002 T5999 pobj activation,upon
R4266 T6046 T6040 conj reporter,A20
R4267 T6003 T6005 nmod [,]
R4268 T6004 T6005 nummod 54,]
R4269 T6005 T6002 appos ],activation
R4270 T6047 T6023 advcl construct,transfected
R4271 T6006 T6005 punct ",",]
R4272 T6007 T6009 nmod [,]
R4273 T6048 T6023 punct .,transfected
R4274 T6049 T6053 compound RIG-I,expression
R4278 T6050 T6051 punct (,2CARD
R4284 T6051 T6049 appos 2CARD,RIG-I
R4288 T6052 T6051 punct ),2CARD
R4291 T6053 T6060 nsubj expression,showed
R4295 T6054 T6053 prep in,expression
R4299 T6055 T6056 det the,absence
R4303 T6056 T6054 pobj absence,in
R4307 T6057 T6056 prep of,absence
R4311 T6058 T6059 compound IRF7,co-expression
R4312 T6059 T6057 pobj co-expression,of
R4313 T6036 T6037 punct (,2CARD
R4314 T6037 T6035 appos 2CARD,RIG-I
R4315 T6038 T6037 punct ),2CARD
R4316 T6060 T6060 ROOT showed,showed
R4317 T6039 T6037 punct ",",2CARD
R4318 T6040 T6037 conj A20,2CARD
R4319 T6041 T6040 cc and,A20
R4320 T6061 T6064 amod negligible,activation
R4321 T6062 T6064 amod IFNα4,activation
R4322 T6063 T6064 compound promoter,activation
R4323 T6064 T6060 dobj activation,showed
R4326 T6065 T6067 punct (,bar
R4332 T6066 T6067 amod grey,bar
R4337 T6067 T6064 appos bar,activation
R4341 T6068 T6067 punct ",",bar
R4344 T6155 T6150 conj macrophages,experiments
R4345 T6156 T6148 punct .,performed
R4346 T6069 T6070 compound figure,1A
R4347 T6157 T6162 mark Since,die
R4348 T6158 T6161 nmod A20,mice
R4349 T6159 T6161 amod full,mice
R4350 T6070 T6064 appos 1A,activation
R4351 T6160 T6161 compound knockout,mice
R4352 T6161 T6162 nsubj mice,die
R4353 T6162 T6176 advcl die,generated
R4354 T6071 T6073 punct ",",graph
R4355 T6163 T6162 advmod prematurely,die
R4356 T6164 T6162 prep as,die
R4357 T6072 T6073 amod right,graph
R4358 T6165 T6166 det a,result
R4359 T6166 T6164 pobj result,as
R4360 T6167 T6166 prep of,result
R4361 T6168 T6170 amod severe,inflammation
R4362 T6073 T6064 appos graph,activation
R4363 T6169 T6170 amod multi-organ,inflammation
R4364 T6170 T6167 pobj inflammation,of
R4365 T6171 T6173 nmod [,]
R4366 T6074 T6064 punct ),activation
R4367 T6172 T6173 nummod 37,]
R4368 T6173 T6170 appos ],inflammation
R4369 T6075 T6060 punct ",",showed
R4370 T6174 T6176 punct ",",generated
R4371 T6175 T6176 nsubj we,generated
R4372 T6176 T6176 ROOT generated,generated
R4373 T6076 T6082 mark whereas,observed
R4374 T6177 T6176 dobj mice,generated
R4375 T6077 T6080 amod significant,expression
R4376 T6078 T6079 compound reporter,gene
R4379 T6079 T6080 compound gene,expression
R4385 T6080 T6082 nsubjpass expression,observed
R4389 T6081 T6082 auxpass was,observed
R4393 T6082 T6060 advcl observed,showed
R4397 T6083 T6082 prep in,observed
R4398 T6084 T6085 det the,presence
R4400 T6085 T6083 pobj presence,in
R4404 T6086 T6085 prep of,presence
R4408 T6087 T6086 pobj IRF7,of
R4411 T6088 T6060 punct .,showed
R4415 T6089 T6102 advmod Similar,prevented
R4420 T6090 T6089 prep to,Similar
R4421 T6210 T6209 pobj control,under
R4422 T6211 T6210 prep of,control
R4423 T6212 T6215 det the,promoter
R4424 T6091 T6093 poss its,effect
R4425 T6213 T6214 compound lysozyme,M
R4426 T6214 T6215 compound M,promoter
R4427 T6215 T6211 pobj promoter,of
R4428 T6092 T6093 amod inhibitory,effect
R4429 T6216 T6216 ROOT leads,leads
R4430 T6217 T6216 prep to,leads
R4431 T6218 T6219 amod specific,deletion
R4432 T6219 T6217 pobj deletion,to
R4433 T6220 T6219 prep in,deletion
R4434 T6221 T6222 amod myeloid,cells
R4435 T6222 T6220 pobj cells,in
R4436 T6093 T6090 pobj effect,to
R4437 T6223 T6216 cc and,leads
R4438 T6224 T6216 conj allowed,leads
R4439 T6225 T6227 nsubj us,generate
R4440 T6094 T6093 prep on,effect
R4441 T6226 T6227 aux to,generate
R4442 T6227 T6224 ccomp generate,allowed
R4443 T6228 T6229 compound myeloid,cell
R4444 T6229 T6233 amod cell,mice
R4445 T6095 T6094 pobj NF-κB,on
R4446 T6230 T6233 amod specific,mice
R4447 T6231 T6233 compound A20,mice
R4448 T6232 T6233 compound knockout,mice
R4449 T6096 T6095 cc and,NF-κB
R4450 T6233 T6227 dobj mice,generate
R4451 T6234 T6227 conj [,generate
R4452 T6235 T6236 nummod 48,]
R4453 T6097 T6095 conj IRF3,NF-κB
R4454 T6098 T6093 conj activation,effect
R4455 T6099 T6102 punct ",",prevented
R4456 T6236 T6234 dobj ],[
R4457 T6237 T6216 punct .,leads
R4458 T6100 T6102 nsubj A20,prevented
R4459 T6238 T6239 aux To,stimulate
R4460 T6239 T6245 advcl stimulate,transfected
R4461 T6240 T6242 det the,receptor
R4462 T6101 T6102 advmod also,prevented
R4463 T6241 T6242 compound RIG-I,receptor
R4464 T6242 T6239 dobj receptor,stimulate
R4465 T6243 T6245 punct ",",transfected
R4466 T6102 T6102 ROOT prevented,prevented
R4467 T6244 T6245 nsubj we,transfected
R4468 T6245 T6245 ROOT transfected,transfected
R4469 T6246 T6247 compound A20myel-KO,BMDM
R4470 T6103 T6105 amod RIG-I-induced,activation
R4471 T6247 T6245 dobj BMDM,transfected
R4472 T6248 T6247 cc and,BMDM
R4473 T6249 T6250 amod wild,type
R4474 T6104 T6105 compound IRF7,activation
R4475 T6250 T6247 conj type,BMDM
R4476 T6251 T6252 compound control,cells
R4477 T6252 T6250 dobj cells,type
R4478 T6105 T6102 dobj activation,prevented
R4479 T6253 T6252 prep with,cells
R4480 T6254 T6255 amod minimal,amounts
R4481 T6255 T6253 pobj amounts,with
R4482 T6256 T6255 prep of,amounts
R4483 T6106 T6108 punct (,1A
R4486 T6107 T6108 compound figure,1A
R4489 T6108 T6105 appos 1A,activation
R4493 T6109 T6111 punct ",",graph
R4497 T6110 T6111 amod right,graph
R4502 T6111 T6105 conj graph,activation
R4504 T6112 T6105 punct ),activation
R4505 T6113 T6102 punct .,prevented
R4511 T6115 T6116 nsubj results,demonstrate
R4515 T6116 T6116 ROOT demonstrate,demonstrate
R4517 T6280 T6275 cc than,bind
R4518 T6281 T6284 nummod MDA5,]
R4519 T6117 T6118 det the,potential
R4520 T6282 T6284 nmod [,]
R4521 T6283 T6284 nummod 57,]
R4522 T6284 T6275 conj ],bind
R4523 T6285 T6245 punct .,transfected
R4524 T6118 T6116 dobj potential,demonstrate
R4525 T6286 T6298 prep Of,was
R4526 T6287 T6286 pobj note,Of
R4527 T6288 T6298 punct ",",was
R4528 T6119 T6118 prep of,potential
R4529 T6289 T6290 det this,concentration
R4530 T6290 T6298 nsubj concentration,was
R4531 T6291 T6290 prep of,concentration
R4532 T6292 T6291 pobj poly,of
R4533 T6293 T6296 punct (,C
R4534 T6294 T6296 nsubj I,C
R4535 T6295 T6296 punct :,C
R4536 T6120 T6119 pobj A20,of
R4537 T6296 T6290 appos C,concentration
R4538 T6297 T6296 punct ),C
R4539 T6298 T6298 ROOT was,was
R4540 T6121 T6122 aux to,inhibit
R4541 T6299 T6298 acomp unable,was
R4542 T6300 T6301 aux to,induce
R4543 T6122 T6116 advcl inhibit,demonstrate
R4544 T6301 T6299 xcomp induce,unable
R4545 T6302 T6305 amod significant,NF-κB
R4546 T6303 T6305 nummod TLR3,NF-κB
R4547 T6304 T6305 amod dependent,NF-κB
R4548 T6123 T6124 amod RIG-I-induced,NF-κB
R4549 T6305 T6301 dobj NF-κB,induce
R4550 T6306 T6305 cc and,NF-κB
R4551 T6307 T6308 amod IRF3,activation
R4552 T6124 T6122 dobj NF-κB,inhibit
R4553 T6308 T6305 conj activation,NF-κB
R4554 T6309 T6308 cc or,activation
R4555 T6310 T6308 conj cytokine,activation
R4556 T6125 T6124 cc and,NF-κB
R4557 T6311 T6308 conj production,activation
R4558 T6312 T6315 punct (,shown
R4559 T6126 T6127 compound IRF3/7,activation
R4560 T6127 T6124 conj activation,NF-κB
R4561 T6313 T6315 nsubjpass data,shown
R4562 T6314 T6315 neg not,shown
R4563 T6128 T6116 punct .,demonstrate
R4564 T6315 T6298 conj shown,was
R4565 T6316 T6315 punct ),shown
R4566 T6317 T6298 punct .,was
R4567 T6129 T6130 aux To,study
R4568 T6318 T6319 mark As,expected
R4569 T6319 T6328 advcl expected,induced
R4570 T6320 T6328 punct ",",induced
R4571 T6130 T6148 advcl study,performed
R4572 T6321 T6327 nmod poly,transfection
R4573 T6322 T6327 punct (,transfection
R4574 T6323 T6327 nmod I,transfection
R4575 T6131 T6132 det the,effect
R4576 T6324 T6325 punct :,C
R4577 T6325 T6323 appos C,I
R4578 T6326 T6327 punct ),transfection
R4579 T6132 T6130 dobj effect,study
R4580 T6327 T6328 nsubj transfection,induced
R4581 T6328 T6328 ROOT induced,induced
R4582 T6329 T6331 det the,expression
R4583 T6330 T6331 amod rapid,expression
R4584 T6331 T6328 dobj expression,induced
R4585 T6332 T6331 prep of,expression
R4586 T6133 T6132 prep of,effect
R4587 T6134 T6135 advmod endogenously,expressed
R4588 T6135 T6136 amod expressed,A20
R4589 T6136 T6133 pobj A20,of
R4590 T6333 T6332 pobj A20,of
R4591 T6334 T6328 prep in,induced
R4592 T6335 T6336 amod wild,type
R4593 T6336 T6334 pobj type,in
R4594 T6137 T6132 prep on,effect
R4595 T6337 T6328 punct ",",induced
R4596 T6338 T6328 cc but,induced
R4597 T6138 T6139 amod RIG-I-induced,signaling
R4598 T6339 T6340 neg not,in
R4599 T6340 T6340 ROOT in,in
R4600 T6341 T6342 compound A20myel-KO,BMDM
R4601 T6342 T6340 pobj BMDM,in
R4602 T6430 T6426 appos BMDM,C
R4603 T6343 T6345 punct (,1B
R4604 T6344 T6345 compound figure,1B
R4605 T6345 T6328 conj 1B,induced
R4606 T6346 T6348 punct ",",panel
R4607 T6431 T6426 punct ",",C
R4608 T6347 T6348 amod upper,panel
R4609 T6348 T6345 appos panel,1B
R4610 T6349 T6345 punct ),1B
R4611 T6432 T6420 advcl reaching,enhanced
R4612 T6350 T6328 punct .,induced
R4613 T6351 T6363 prep At,observed
R4614 T6352 T6353 amod early,time
R4615 T6353 T6351 pobj time,At
R4616 T6433 T6434 det a,maximum
R4617 T6354 T6363 nsubjpass points,observed
R4618 T6355 T6359 punct ",",forms
R4619 T6356 T6357 advmod slightly,slower
R4620 T6434 T6432 dobj maximum,reaching
R4621 T6357 T6359 amod slower,forms
R4622 T6358 T6359 amod migrating,forms
R4623 T6359 T6363 nsubjpass forms,observed
R4624 T6435 T6432 prep at,reaching
R4625 T6360 T6359 prep of,forms
R4626 T6361 T6360 pobj A20,of
R4627 T6362 T6363 auxpass were,observed
R4628 T6436 T6437 amod earlier,time
R4629 T6363 T6363 ROOT observed,observed
R4630 T6364 T6363 punct ",",observed
R4631 T6365 T6363 advcl indicating,observed
R4632 T6366 T6368 mark that,undergoes
R4633 T6367 T6368 nsubj A20,undergoes
R4634 T6368 T6365 ccomp undergoes,indicating
R4635 T6369 T6372 det a,modification
R4636 T6437 T6438 compound time,points
R4637 T6370 T6371 advmod yet,unknown
R4638 T6371 T6372 amod unknown,modification
R4639 T6372 T6368 dobj modification,undergoes
R4640 T6373 T6372 prep upon,modification
R4641 T6438 T6435 pobj points,at
R4642 T6374 T6373 pobj poly,upon
R4643 T6375 T6372 punct (,modification
R4644 T6376 T6378 nsubj I,C
R4645 T6439 T6420 prep compared,enhanced
R4646 T6377 T6378 punct :,C
R4647 T6378 T6372 appos C,modification
R4648 T6379 T6378 punct ),C
R4649 T6440 T6439 prep to,compared
R4650 T6380 T6372 appos transfection,modification
R4651 T6381 T6363 punct .,observed
R4652 T6382 T6391 prep Compared,showed
R4653 T6441 T6443 amod wild,cells
R4654 T6383 T6382 prep to,Compared
R4655 T6384 T6385 amod wild,type
R4656 T6385 T6386 compound type,BMBM
R4657 T6442 T6443 compound type,cells
R4658 T6386 T6383 pobj BMBM,to
R4659 T6387 T6386 punct ",",BMBM
R4660 T6388 T6390 amod A20,cells
R4661 T6443 T6440 pobj cells,to
R4662 T6389 T6390 amod deficient,cells
R4663 T6444 T6446 punct (,1C
R4664 T6390 T6391 nsubj cells,showed
R4665 T6445 T6446 compound figure,1C
R4666 T6391 T6391 ROOT showed,showed
R4667 T6392 T6394 amod enhanced,activation
R4668 T6393 T6394 compound NF-κB,activation
R4669 T6446 T6443 appos 1C,cells
R4670 T6394 T6391 dobj activation,showed
R4671 T6395 T6396 mark as,indicated
R4672 T6396 T6391 advcl indicated,showed
R4673 T6447 T6420 punct ),enhanced
R4674 T6397 T6396 agent by,indicated
R4675 T6398 T6399 amod increased,phosphorylation
R4676 T6448 T6420 punct .,enhanced
R4677 T6399 T6397 pobj phosphorylation,by
R4678 T6400 T6399 cc and,phosphorylation
R4679 T6401 T6402 amod sustained,degradation
R4680 T6449 T6451 nsubjpass IRF3,known
R4681 T6402 T6399 conj degradation,phosphorylation
R4682 T6403 T6402 prep of,degradation
R4683 T6404 T6403 pobj IκBα,of
R4684 T6405 T6407 punct (,1B
R4685 T6406 T6407 compound figure,1B
R4686 T6407 T6404 appos 1B,IκBα
R4687 T6450 T6451 auxpass is,known
R4688 T6408 T6407 punct ),1B
R4689 T6409 T6391 punct .,showed
R4690 T6410 T6420 advmod Furthermore,enhanced
R4691 T6411 T6420 punct ",",enhanced
R4692 T6451 T6451 ROOT known,known
R4693 T6412 T6413 amod nuclear,translocation
R4694 T6413 T6420 nsubjpass translocation,enhanced
R4695 T6452 T6454 aux to,activated
R4696 T6414 T6413 prep of,translocation
R4697 T6415 T6418 det the,subunit
R4698 T6416 T6418 nummod p65,subunit
R4699 T6417 T6418 compound NF-κB,subunit
R4700 T6453 T6454 auxpass be,activated
R4701 T6418 T6414 pobj subunit,of
R4702 T6419 T6420 auxpass was,enhanced
R4703 T6420 T6420 ROOT enhanced,enhanced
R4704 T6454 T6451 xcomp activated,known
R4705 T6421 T6420 prep in,enhanced
R4706 T6422 T6421 pobj poly,in
R4707 T6423 T6426 punct (,C
R4708 T6455 T6454 prep upon,activated
R4709 T6424 T6426 nsubj I,C
R4710 T6425 T6426 punct :,C
R4711 T6426 T6420 parataxis C,enhanced
R4712 T6427 T6426 punct ),C
R4713 T6456 T6455 pobj phosphorylation,upon
R4714 T6428 T6430 amod transfected,BMDM
R4715 T6429 T6430 compound A20myel-KO,BMDM
R4716 T6457 T6456 prep of,phosphorylation
R4717 T6458 T6459 det a,series
R4718 T6459 T6457 pobj series,of
R4719 T6527 T6528 amod nuclear,translocation
R4720 T6528 T6529 nsubj translocation,reached
R4721 T6460 T6459 prep of,series
R4722 T6529 T6529 ROOT reached,reached
R4723 T6530 T6531 poss its,maximum
R4724 T6531 T6529 dobj maximum,reached
R4725 T6461 T6462 compound carboxyl,terminal
R4726 T6532 T6529 prep at,reached
R4727 T6533 T6536 det an,point
R4728 T6534 T6535 amod earlier,time
R4729 T6462 T6464 compound terminal,residues
R4730 T6535 T6536 compound time,point
R4731 T6536 T6532 pobj point,at
R4732 T6463 T6464 compound serine,residues
R4733 T6537 T6529 prep in,reached
R4734 T6538 T6540 nummod A20,BMDM
R4735 T6539 T6540 amod deficient,BMDM
R4736 T6540 T6537 pobj BMDM,in
R4737 T6541 T6529 prep compared,reached
R4738 T6542 T6541 prep to,compared
R4739 T6464 T6460 pobj residues,of
R4740 T6543 T6545 amod wild,cells
R4741 T6544 T6545 compound type,cells
R4742 T6545 T6542 pobj cells,to
R4743 T6546 T6548 punct (,1C
R4744 T6465 T6459 prep by,series
R4745 T6547 T6548 compound figure,1C
R4746 T6466 T6468 det the,kinases
R4747 T6467 T6468 amod IKK-like,kinases
R4751 T6468 T6465 pobj kinases,by
R4755 T6469 T6468 appos TBK1,kinases
R4759 T6470 T6469 cc and,TBK1
R4763 T6471 T6472 compound IKKε,[
R4766 T6472 T6469 conj [,TBK1
R4770 T6473 T6474 nummod 58,]
R4771 T6565 T6566 det the,expression
R4772 T6566 T6564 dobj expression,control
R4773 T6567 T6566 prep of,expression
R4774 T6568 T6567 pobj IFNβ,of
R4775 T6474 T6474 ROOT ],]
R4776 T6569 T6564 punct .,control
R4777 T6570 T6586 prep In,secreted
R4778 T6571 T6570 pobj line,In
R4779 T6475 T6474 punct ",",]
R4780 T6572 T6571 prep with,line
R4781 T6573 T6575 det the,activation
R4782 T6476 T6474 acl leading,]
R4783 T6574 T6575 amod enhanced,activation
R4784 T6575 T6572 pobj activation,with
R4785 T6576 T6575 prep of,activation
R4786 T6577 T6576 pobj NF-κB,of
R4787 T6578 T6577 cc and,NF-κB
R4788 T6579 T6577 conj IRF3,NF-κB
R4789 T6580 T6581 mark as,described
R4790 T6477 T6476 prep to,leading
R4791 T6581 T6586 advcl described,secreted
R4792 T6582 T6581 prep above,described
R4793 T6583 T6586 punct ",",secreted
R4794 T6584 T6585 compound A20myel-KO,BMDM
R4795 T6478 T6479 poss its,dimerization
R4796 T6585 T6586 nsubj BMDM,secreted
R4797 T6586 T6586 ROOT secreted,secreted
R4798 T6479 T6477 pobj dimerization,to
R4799 T6587 T6588 amod increased,amounts
R4800 T6588 T6586 dobj amounts,secreted
R4801 T6589 T6588 prep of,amounts
R4802 T6480 T6479 cc and,dimerization
R4803 T6590 T6589 pobj IL-6,of
R4804 T6591 T6590 punct ",",IL-6
R4805 T6592 T6590 conj TNF,IL-6
R4806 T6481 T6482 amod subsequent,translocation
R4807 T6593 T6592 cc and,TNF
R4808 T6594 T6592 conj IFNβ,TNF
R4809 T6595 T6596 punct (,figure
R4810 T6482 T6479 conj translocation,dimerization
R4811 T6596 T6597 nsubj figure,1D
R4812 T6597 T6588 acl 1D,amounts
R4813 T6598 T6588 punct ),amounts
R4814 T6483 T6477 prep to,to
R4815 T6599 T6586 punct .,secreted
R4816 T6600 T6601 amod Similar,results
R4817 T6601 T6603 nsubjpass results,obtained
R4818 T6602 T6603 auxpass were,obtained
R4819 T6484 T6485 det the,nucleus
R4820 T6485 T6483 pobj nucleus,to
R4821 T6486 T6477 pobj [,to
R4822 T6603 T6603 ROOT obtained,obtained
R4823 T6487 T6488 nummod 59,]
R4824 T6604 T6603 advcl using,obtained
R4825 T6605 T6606 amod peritoneal,macrophages
R4826 T6488 T6486 dobj ],[
R4827 T6606 T6604 dobj macrophages,using
R4828 T6607 T6606 punct (,macrophages
R4829 T6608 T6606 appos data,macrophages
R4830 T6609 T6610 neg not,shown
R4831 T6489 T6451 punct .,known
R4832 T6610 T6608 acl shown,data
R4833 T6490 T6504 advcl Using,detected
R4837 T6491 T6490 dobj immunoblotting,Using
R4841 T6492 T6491 prep with,immunoblotting
R4845 T6493 T6494 det an,antibody
R4848 T6494 T6492 pobj antibody,with
R4852 T6495 T6494 acl directed,antibody
R4855 T6496 T6495 prep against,directed
R4856 T6497 T6498 compound phosphorylated,Ser396
R4857 T6498 T6496 pobj Ser396,against
R4858 T6627 T6624 pobj regulation,in
R4859 T6628 T6627 prep of,regulation
R4860 T6499 T6498 punct ",",Ser396
R4861 T6629 T6630 amod RIG-I-induced,NF-κB
R4862 T6630 T6628 pobj NF-κB,of
R4863 T6631 T6630 cc and,NF-κB
R4864 T6500 T6502 amod maximum,phosphorylation
R4865 T6632 T6633 amod IRF3,activation
R4866 T6633 T6630 conj activation,NF-κB
R4867 T6634 T6633 prep in,activation
R4868 T6501 T6502 nummod IRF3,phosphorylation
R4869 T6635 T6636 amod primary,macrophages
R4870 T6636 T6634 pobj macrophages,in
R4871 T6502 T6498 appos phosphorylation,Ser396
R4872 T6637 T6617 punct .,demonstrate
R4873 T6503 T6504 auxpass was,detected
R4874 T6504 T6504 ROOT detected,detected
R4875 T6505 T6504 prep at,detected
R4876 T6506 T6507 amod earlier,time
R4877 T6507 T6505 pobj time,at
R4878 T6508 T6512 nsubj points,compared
R4879 T6509 T6508 prep in,points
R4880 T6510 T6511 compound A20myel-KO,BMDM
R4881 T6511 T6509 pobj BMDM,in
R4882 T6512 T6504 prep compared,detected
R4883 T6513 T6512 prep to,compared
R4884 T6514 T6515 amod wild,type
R4885 T6515 T6516 compound type,BMDM
R4886 T6516 T6513 pobj BMDM,to
R4887 T6517 T6519 punct (,1B
R4888 T6518 T6519 compound figure,1B
R4889 T6519 T6516 appos 1B,BMDM
R4890 T6520 T6519 punct ),1B
R4891 T6521 T6504 punct .,detected
R4892 T6522 T6529 advcl Similar,reached
R4893 T6523 T6524 aux to,p65
R4894 T6524 T6522 xcomp p65,Similar
R4895 T6525 T6524 punct ",",p65
R4896 T6526 T6524 dep IRF3,p65
R5706 T8079 T8081 nsubj A20,regulates
R5707 T8080 T8081 advmod negatively,regulates
R5708 T8081 T8104 ccomp regulates,infected
R5709 T8082 T8084 amod IAV-induced,expression
R5710 T8083 T8084 compound gene,expression
R5711 T8084 T8081 dobj expression,regulates
R5712 T8085 T8084 prep in,expression
R5713 T8086 T8085 pobj BMDM,in
R5714 T8087 T8088 aux To,investigate
R5715 T8088 T8081 advcl investigate,regulates
R5716 T8089 T8090 det the,role
R5717 T8090 T8088 dobj role,investigate
R5718 T8091 T8090 prep of,role
R5719 T8092 T8091 pobj A20,of
R5720 T8093 T8090 prep in,role
R5721 T8094 T8101 det the,responses
R5722 T8095 T8101 amod IAV-induced,responses
R5723 T8096 T8095 conj proinflammatory,IAV-induced
R5724 T8097 T8096 cc and,proinflammatory
R5725 T8098 T8096 conj antiviral,proinflammatory
R5726 T8099 T8101 amod innate,responses
R5727 T8100 T8101 amod immune,responses
R5728 T8101 T8093 pobj responses,in
R5729 T8102 T8104 punct ",",infected
R5730 T8103 T8104 nsubj we,infected
R5731 T8104 T8104 ROOT infected,infected
R5732 T8105 T8106 compound A20,deficient
R5733 T8106 T8109 nmod deficient,BMDM
R5734 T8107 T8106 cc and,deficient
R5735 T8108 T8106 conj control,deficient
R5736 T8109 T8104 dobj BMDM,infected
R5737 T8110 T8104 prep with,infected
R5738 T8111 T8112 compound IAV,X-47
R5739 T8112 T8110 pobj X-47,with
R5740 T8113 T8112 punct (,X-47
R5741 T8114 T8112 appos H3N2,X-47
R5742 T8115 T8112 punct ),X-47
R5743 T8116 T8104 punct .,infected
R5744 T8117 T8119 nummod A20,levels
R5745 T8118 T8119 compound mRNA,levels
R5746 T8119 T8122 nsubjpass levels,induced
R5747 T8120 T8122 auxpass were,induced
R5748 T8121 T8122 advmod rapidly,induced
R5749 T8122 T8122 ROOT induced,induced
R5750 T8123 T8122 prep in,induced
R5751 T8124 T8125 amod wild,type
R5752 T8125 T8126 compound type,BMDM
R5753 T8126 T8123 pobj BMDM,in
R5754 T8127 T8122 punct ",",induced
R5755 T8128 T8122 cc but,induced
R5756 T8129 T8130 neg not,in
R5757 T8130 T8122 conj in,induced
R5758 T8131 T8130 pobj A20,in
R5759 T8132 T8133 amod deficient,BMDM
R5760 T8133 T8130 conj BMDM,in
R5761 T8134 T8135 punct ",",upon
R5762 T8135 T8133 prep upon,BMDM
R5763 T8136 T8137 amod viral,infection
R5764 T8137 T8135 pobj infection,upon
R5765 T8138 T8140 punct (,2A
R5766 T8139 T8140 compound figure,2A
R5767 T8140 T8137 appos 2A,infection
R5768 T8141 T8140 punct ),2A
R5769 T8142 T8122 punct .,induced
R5770 T8143 T8147 advmod Furthermore,show
R5771 T8144 T8147 punct ",",show
R5772 T8145 T8147 compound A20myel-KO,show
R5773 T8146 T8147 compound BMDM,show
R5774 T8147 T8147 ROOT show,show
R5775 T8148 T8149 amod enhanced,expression
R5776 T8149 T8147 dobj expression,show
R5777 T8150 T8149 prep of,expression
R5778 T8151 T8150 pobj IL-6,of
R5779 T8152 T8151 cc and,IL-6
R5780 T8153 T8154 compound IFNβ,mRNA
R5781 T8154 T8147 appos mRNA,show
R5782 T8155 T8158 mark after,compared
R5783 T8156 T8157 compound IAV,infection
R5784 T8157 T8158 nsubj infection,compared
R5785 T8158 T8147 advcl compared,show
R5786 T8159 T8160 aux to,control
R5787 T8160 T8158 xcomp control,compared
R5788 T8161 T8160 dobj cells,control
R5789 T8162 T8161 punct (,cells
R5790 T8163 T8164 compound figure,2A
R5791 T8164 T8161 appos 2A,cells
R5792 T8165 T8161 punct ),cells
R5793 T8166 T8147 punct .,show
R5794 T8167 T8180 prep In,contained
R5795 T8168 T8167 pobj accordance,In
R5796 T8169 T8168 prep with,accordance
R5797 T8170 T8171 det these,data
R5798 T8171 T8169 pobj data,with
R5799 T8172 T8180 punct ",",contained
R5800 T8173 T8174 compound cell,culture
R5801 T8174 T8175 compound culture,supernatant
R5802 T8175 T8180 nsubj supernatant,contained
R5803 T8176 T8175 acl collected,supernatant
R5804 T8177 T8176 prep from,collected
R5805 T8178 T8179 det these,cells
R5806 T8179 T8177 pobj cells,from
R5807 T8180 T8180 ROOT contained,contained
R5808 T8181 T8182 amod higher,levels
R5809 T8182 T8180 dobj levels,contained
R5810 T8183 T8182 prep of,levels
R5811 T8184 T8183 pobj TNF,of
R5812 T8185 T8184 cc and,TNF
R5813 T8186 T8184 conj IFNβ,TNF
R5814 T8187 T8189 punct (,2B
R5815 T8188 T8189 compound figure,2B
R5816 T8189 T8186 appos 2B,IFNβ
R5817 T8190 T8186 punct ),IFNβ
R5827 T8200 T8200 ROOT are,are
R5828 T8201 T8203 det an,source
R5829 T8202 T8203 amod important,source
R5830 T8203 T8200 attr source,are
R5831 T8204 T8203 prep of,source
R5832 T8205 T8204 pobj cytokines,of
R5833 T8206 T8205 cc and,cytokines
R5834 T8207 T8205 conj chemokines,cytokines
R5835 T8208 T8200 punct ",",are
R5836 T8209 T8200 advcl attracting,are
R5837 T8210 T8212 amod innate,cells
R5838 T8211 T8212 amod immune,cells
R5839 T8212 T8209 dobj cells,attracting
R5840 T8213 T8209 prep to,attracting
R5841 T8214 T8215 det the,lung
R5842 T8215 T8213 pobj lung,to
R5843 T8216 T8209 prep during,attracting
R5844 T8217 T8219 det the,phase
R5845 T8218 T8219 amod primary,phase
R5846 T8219 T8216 pobj phase,during
R5847 T8220 T8219 prep of,phase
R5848 T8221 T8220 pobj infection,of
R5849 T8222 T8200 punct .,are
R5850 T8223 T8224 aux To,test
R5851 T8224 T8237 advcl test,isolated
R5852 T8225 T8228 mark whether,controls
R5853 T8226 T8228 nsubj A20,controls
R5854 T8227 T8228 advmod directly,controls
R5855 T8228 T8237 advcl controls,isolated
R5856 T8229 T8231 amod IAV-induced,expression
R5857 T8230 T8231 compound gene,expression
R5858 T8231 T8228 dobj expression,controls
R5859 T8232 T8231 prep in,expression
R5860 T8233 T8234 amod alveolar,macrophages
R5861 T8234 T8232 pobj macrophages,in
R5862 T8235 T8237 punct ",",isolated
R5863 T8236 T8237 nsubj we,isolated
R5864 T8237 T8237 ROOT isolated,isolated
R5865 T8238 T8239 det these,cells
R5866 T8239 T8237 dobj cells,isolated
R5867 T8240 T8237 prep from,isolated
R5868 T8241 T8240 pobj lungs,from
R5869 T8242 T8241 prep of,lungs
R5870 T8243 T8242 pobj A20myel-KO,of
R5871 T8244 T8243 cc and,A20myel-KO
R5872 T8245 T8243 conj control,A20myel-KO
R5873 T8246 T8243 conj littermates,A20myel-KO
R5874 T8247 T8237 cc and,isolated
R5875 T8248 T8237 conj infected,isolated
R5876 T8249 T8248 dobj them,infected
R5877 T8250 T8248 prep in,infected
R5878 T8251 T8250 pobj vitro,in
R5879 T8252 T8248 prep with,infected
R5880 T8253 T8254 compound IAV,X-47
R5881 T8254 T8252 pobj X-47,with
R5882 T8255 T8237 punct .,isolated
R5883 T8256 T8285 nsubj Expression,was
R5884 T8257 T8256 cc and,Expression
R5885 T8258 T8256 conj secretion,Expression
R5886 T8259 T8258 prep of,secretion
R5887 T8260 T8262 det the,cytokines
R5888 T8261 T8262 amod proinflammatory,cytokines
R5889 T8262 T8263 compound cytokines,IL-6
R5890 T8263 T8259 pobj IL-6,of
R5891 T8264 T8263 cc and,IL-6
R5892 T8265 T8263 conj TNF,IL-6
R5893 T8266 T8265 punct ",",TNF
R5894 T8267 T8270 det the,IFNβ
R5895 T8268 T8270 compound type-I,IFNβ
R5896 T8269 T8270 compound IFN,IFNβ
R5897 T8270 T8265 conj IFNβ,TNF
R5898 T8271 T8270 cc and,IFNβ
R5899 T8272 T8270 conj IFNα4,IFNβ
R5900 T8273 T8272 cc and,IFNα4
R5901 T8274 T8275 det the,chemokines
R5902 T8275 T8272 conj chemokines,IFNα4
R5903 T8276 T8285 nsubj MCP-1,was
R5904 T8277 T8278 punct (,ccl2
R5905 T8278 T8276 parataxis ccl2,MCP-1
R5906 T8279 T8278 punct ),ccl2
R5907 T8280 T8276 cc and,MCP-1
R5908 T8281 T8276 conj KC,MCP-1
R5909 T8282 T8283 punct (,cxcl1
R5910 T8283 T8276 appos cxcl1,MCP-1
R5911 T8284 T8276 punct ),MCP-1
R5912 T8285 T8285 ROOT was,was
R5913 T8286 T8287 advmod significantly,higher
R5914 T8287 T8285 acomp higher,was
R5915 T8288 T8285 prep in,was
R5916 T8289 T8291 nmod IAV,cells
R5917 T8290 T8291 amod infected,cells
R5918 T8291 T8288 pobj cells,in
R5919 T8292 T8291 acl lacking,cells
R5920 T8293 T8292 dobj A20,lacking
R5921 T8294 T8285 prep compared,was
R5922 T8295 T8294 prep to,compared
R5923 T8296 T8299 amod infected,cells
R5924 T8297 T8299 amod wild,cells
R5925 T8298 T8299 compound type,cells
R5926 T8299 T8295 pobj cells,to
R5927 T8300 T8301 punct (,figure
R5928 T8301 T8299 parataxis figure,cells
R5929 T8302 T8301 npadvmod 2C,figure
R5930 T8303 T8302 cc and,2C
R5931 T8304 T8302 conj figure,2C
R5932 T8305 T8304 nummod S1,figure
R5933 T8306 T8301 punct ),figure
R5934 T8307 T8285 punct .,was
R5935 T8308 T8312 prep Taken,demonstrate
R5936 T8309 T8308 advmod together,Taken
R5937 T8310 T8311 det these,results
R5938 T8311 T8312 nsubj results,demonstrate
R5939 T8312 T8312 ROOT demonstrate,demonstrate
R5940 T8313 T8316 mark that,regulates
R5941 T8314 T8316 nsubj A20,regulates
R5942 T8315 T8316 advmod negatively,regulates
R5943 T8316 T8312 ccomp regulates,demonstrate
R5944 T8317 T8322 amod IAV-induced,expression
R5945 T8318 T8322 amod proinflammatory,expression
R5946 T8319 T8318 cc and,proinflammatory
R5947 T8320 T8318 conj antiviral,proinflammatory
R5948 T8321 T8322 compound gene,expression
R5949 T8322 T8316 dobj expression,regulates
R5950 T8323 T8322 prep in,expression
R5951 T8324 T8325 amod alveolar,macrophages
R5952 T8325 T8323 pobj macrophages,in
R5953 T8326 T8322 punct ",",expression
R5954 T8327 T8322 amod consistent,expression
R5955 T8328 T8327 prep with,consistent
R5956 T8329 T8331 det the,effect
R5957 T8330 T8331 amod inhibitory,effect
R5958 T8331 T8328 pobj effect,with
R5959 T8332 T8331 prep of,effect
R5960 T8333 T8332 pobj A20,of
R5961 T8334 T8331 acl seen,effect
R5962 T8335 T8334 prep on,seen
R5963 T8336 T8337 amod RIG-I-induced,NF-κB
R5964 T8337 T8335 pobj NF-κB,on
R5965 T8338 T8337 cc and,NF-κB
R5966 T8339 T8340 amod IRF3,activation
R5967 T8340 T8337 conj activation,NF-κB
R5968 T8341 T8312 punct .,demonstrate
R7245 T9997 T9998 nummod A20,deficiency
R7246 T9998 T10002 nsubj deficiency,protects
R7247 T9999 T9998 prep in,deficiency
R7248 T10000 T10001 amod myeloid,cells
R7249 T10001 T9999 pobj cells,in
R7250 T10002 T10026 ccomp protects,inoculated
R7251 T10003 T10002 prep against,protects
R7252 T10004 T10006 compound IAV,infection
R7253 T10005 T10006 compound lung,infection
R7254 T10006 T10003 pobj infection,against
R7255 T10007 T10008 aux To,determine
R7256 T10008 T10002 advcl determine,protects
R7257 T10009 T10010 det the,role
R7258 T10010 T10008 dobj role,determine
R7259 T10011 T10010 prep of,role
R7260 T10012 T10013 compound A20,expression
R7261 T10013 T10011 pobj expression,of
R7262 T10014 T10013 prep in,expression
R7263 T10015 T10016 amod myeloid,cells
R7264 T10016 T10014 pobj cells,in
R7265 T10017 T10010 prep during,role
R7266 T10018 T10020 det an,infection
R7267 T10019 T10020 compound IAV,infection
R7268 T10020 T10017 pobj infection,during
R7269 T10021 T10020 prep in,infection
R7270 T10022 T10021 pobj vivo,in
R7271 T10023 T10026 punct ",",inoculated
R7272 T10024 T10026 nsubj we,inoculated
R7273 T10025 T10026 advmod intranasally,inoculated
R7274 T10026 T10026 ROOT inoculated,inoculated
R7275 T10027 T10029 det both,mice
R7276 T10028 T10029 amod A20myel-KO,mice
R7277 T10029 T10026 dobj mice,inoculated
R7278 T10030 T10029 cc and,mice
R7279 T10031 T10032 compound control,littermates
R7280 T10032 T10029 conj littermates,mice
R7281 T10033 T10026 prep with,inoculated
R7282 T10034 T10036 det a,dose
R7283 T10035 T10036 amod sublethal,dose
R7284 T10036 T10033 pobj dose,with
R7285 T10037 T10036 prep of,dose
R7286 T10038 T10039 det the,mouse
R7287 T10039 T10037 pobj mouse,of
R7288 T10040 T10026 conj adapted,inoculated
R7289 T10041 T10042 compound IAV,X-47
R7290 T10042 T10040 dobj X-47,adapted
R7291 T10043 T10044 punct (,H3N2
R7292 T10044 T10042 appos H3N2,X-47
R7293 T10045 T10042 punct ),X-47
R7294 T10046 T10040 dobj strain,adapted
R7295 T10047 T10040 cc and,adapted
R7296 T10048 T10040 conj monitored,adapted
R7297 T10049 T10048 dobj morbidity,monitored
R7298 T10050 T10048 prep in,monitored
R7299 T10051 T10050 pobj terms,in
R7300 T10052 T10051 prep of,terms
R7301 T10053 T10054 compound weight,loss
R7302 T10054 T10052 pobj loss,of
R7303 T10055 T10026 punct .,inoculated
R7304 T10056 T10057 amod A20myel-KO,mice
R7305 T10057 T10058 nsubj mice,showed
R7306 T10058 T10058 ROOT showed,showed
R7307 T10059 T10061 amod reduced,loss
R7308 T10060 T10061 compound weight,loss
R7309 T10061 T10058 dobj loss,showed
R7310 T10062 T10058 prep compared,showed
R7311 T10063 T10062 prep to,compared
R7312 T10064 T10066 amod wild,control
R7313 T10065 T10066 compound type,control
R7314 T10066 T10067 compound control,littermates
R7315 T10067 T10063 pobj littermates,to
R7316 T10068 T10062 cc and,compared
R7317 T10069 T10062 conj recovered,compared
R7318 T10070 T10069 advmod faster,recovered
R7319 T10071 T10070 prep from,faster
R7320 T10072 T10074 det the,challenge
R7321 T10073 T10074 amod viral,challenge
R7322 T10074 T10071 pobj challenge,from
R7323 T10075 T10076 punct (,figure
R7324 T10076 T10077 compound figure,3A
R7325 T10077 T10070 appos 3A,faster
R7326 T10078 T10070 punct ),faster
R7327 T10079 T10058 punct .,showed
R7328 T10080 T10098 advmod Also,increased
R7329 T10081 T10098 punct ",",increased
R7330 T10082 T10084 amod total,concentration
R7331 T10083 T10084 compound protein,concentration
R7332 T10084 T10098 nsubjpass concentration,increased
R7333 T10085 T10084 prep in,concentration
R7334 T10086 T10087 compound BAL,fluid
R7335 T10087 T10085 pobj fluid,in
R7336 T10088 T10087 punct ",",fluid
R7337 T10089 T10090 nsubj which,reflects
R7338 T10090 T10087 relcl reflects,fluid
R7339 T10091 T10092 compound lung,damage
R7340 T10092 T10090 dobj damage,reflects
R7341 T10093 T10092 cc and,damage
R7342 T10094 T10095 amod vascular,leakage
R7343 T10095 T10092 conj leakage,damage
R7344 T10096 T10098 punct ",",increased
R7345 T10097 T10098 auxpass was,increased
R7346 T10098 T10098 ROOT increased,increased
R7347 T10099 T10098 advmod significantly,increased
R7348 T10100 T10098 prep at,increased
R7349 T10101 T10104 nummod 7,days
R7350 T10102 T10101 cc and,7
R7351 T10103 T10101 conj 10,7
R7352 T10104 T10105 compound days,post
R7353 T10105 T10106 compound post,infection
R7354 T10106 T10100 pobj infection,at
R7355 T10107 T10098 prep in,increased
R7356 T10108 T10110 det both,type
R7357 T10109 T10110 amod wild,type
R7358 T10110 T10107 pobj type,in
R7359 T10111 T10110 cc and,type
R7360 T10112 T10113 amod A20myel-KO,mice
R7361 T10113 T10110 conj mice,type
R7362 T10114 T10098 punct ",",increased
R7363 T10115 T10098 cc and,increased
R7364 T10116 T10098 conj was,increased
R7365 T10117 T10118 advmod slightly,lower
R7366 T10118 T10116 acomp lower,was
R7367 T10119 T10116 prep in,was
R7368 T10120 T10121 amod A20myel-KO,mice
R7369 T10121 T10119 pobj mice,in
R7370 T10122 T10123 punct (,data
R7371 T10123 T10121 appos data,mice
R7372 T10124 T10125 neg not,shown
R7373 T10125 T10123 acl shown,data
R7374 T10126 T10123 punct ),data
R7375 T10127 T10098 punct .,increased
R7376 T10128 T10131 advmod Next,measured
R7377 T10129 T10131 punct ",",measured
R7378 T10130 T10131 nsubj we,measured
R7379 T10131 T10131 ROOT measured,measured
R7380 T10132 T10134 amod pulmonary,titers
R7381 T10133 T10134 amod viral,titers
R7382 T10134 T10131 dobj titers,measured
R7383 T10135 T10131 prep at,measured
R7384 T10136 T10135 pobj 4,at
R7385 T10137 T10131 punct ",",measured
R7386 T10138 T10141 nummod 7,days
R7387 T10139 T10138 cc and,7
R7388 T10140 T10138 conj 10,7
R7389 T10141 T10143 npadvmod days,infection
R7390 T10142 T10143 compound post,infection
R7391 T10143 T10131 advmod infection,measured
R7392 T10144 T10131 punct .,measured
R7393 T10145 T10146 det No,differences
R7394 T10146 T10151 nsubjpass differences,observed
R7395 T10147 T10146 prep in,differences
R7396 T10148 T10149 amod viral,titers
R7397 T10149 T10147 pobj titers,in
R7398 T10150 T10151 auxpass were,observed
R7399 T10151 T10151 ROOT observed,observed
R7400 T10152 T10151 prep in,observed
R7401 T10153 T10154 amod A20myel-KO,mice
R7402 T10154 T10152 pobj mice,in
R7403 T10155 T10154 cc versus,mice
R7404 T10156 T10158 amod wild,mice
R7405 T10157 T10158 compound type,mice
R7406 T10158 T10154 conj mice,mice
R7407 T10159 T10151 prep at,observed
R7408 T10160 T10159 pobj day,at
R7409 T10161 T10160 nummod 4,day
R7410 T10162 T10151 cc and,observed
R7411 T10163 T10165 nummod 7,infection
R7412 T10164 T10165 compound post,infection
R7413 T10165 T10151 conj infection,observed
R7414 T10166 T10151 punct .,observed
R7415 T10167 T10178 advmod However,detected
R7416 T10168 T10178 punct ",",detected
R7417 T10169 T10178 prep after,detected
R7418 T10170 T10171 nummod 10,days
R7419 T10171 T10169 pobj days,after
R7420 T10172 T10178 punct ",",detected
R7421 T10173 T10174 advmod almost,no
R7422 T10174 T10175 nummod no,virus
R7423 T10175 T10178 nsubjpass virus,detected
R7424 T10176 T10178 aux could,detected
R7425 T10177 T10178 auxpass be,detected
R7426 T10178 T10178 ROOT detected,detected
R7427 T10179 T10178 prep in,detected
R7428 T10180 T10181 det the,lungs
R7429 T10181 T10179 pobj lungs,in
R7430 T10182 T10181 prep of,lungs
R7431 T10183 T10184 amod A20myel-KO,mice
R7441 T10193 T10178 advcl isolated,detected
R7442 T10194 T10193 prep from,isolated
R7443 T10195 T10194 pobj lungs,from
R7444 T10196 T10195 prep of,lungs
R7445 T10197 T10200 det all,mice
R7446 T10198 T10200 amod wild,mice
R7447 T10199 T10200 compound type,mice
R7448 T10200 T10196 pobj mice,of
R7449 T10201 T10203 punct (,3B
R7450 T10202 T10203 compound figure,3B
R7451 T10203 T10200 appos 3B,mice
R7452 T10204 T10200 punct ),mice
R7453 T10205 T10178 punct .,detected
R7454 T10206 T10207 nsubj This,indicates
R7455 T10207 T10207 ROOT indicates,indicates
R7456 T10208 T10217 mark that,affect
R7457 T10209 T10217 nsubj loss,affect
R7458 T10210 T10209 prep of,loss
R7459 T10211 T10210 pobj A20,of
R7460 T10212 T10209 prep in,loss
R7461 T10213 T10214 amod myeloid,cells
R7462 T10214 T10212 pobj cells,in
R7463 T10215 T10217 aux does,affect
R7464 T10216 T10217 neg not,affect
R7465 T10217 T10207 ccomp affect,indicates
R7466 T10218 T10220 amod early,replication
R7467 T10219 T10220 amod viral,replication
R7468 T10220 T10217 dobj replication,affect
R7469 T10221 T10217 cc but,affect
R7470 T10222 T10207 conj contributes,indicates
R7471 T10223 T10222 prep to,contributes
R7472 T10224 T10225 amod viral,clearance
R7473 T10225 T10223 pobj clearance,to
R7474 T10226 T10222 prep at,contributes
R7475 T10227 T10228 amod later,stages
R7476 T10228 T10226 pobj stages,at
R7477 T10229 T10222 prep during,contributes
R7478 T10230 T10229 pobj infection,during
R7479 T10231 T10207 punct .,indicates
R7480 T10232 T10233 aux To,verify
R7481 T10233 T10249 advcl verify,analyzed
R7482 T10234 T10240 mark if,affects
R7483 T10235 T10236 compound A20,deficiency
R7484 T10236 T10240 nsubj deficiency,affects
R7485 T10237 T10236 prep in,deficiency
R7486 T10238 T10239 amod myeloid,cells
R7487 T10239 T10237 pobj cells,in
R7488 T10240 T10249 advcl affects,analyzed
R7489 T10241 T10243 amod IAV-induced,expression
R7490 T10242 T10243 compound gene,expression
R7491 T10243 T10240 dobj expression,affects
R7492 T10244 T10243 prep in,expression
R7493 T10245 T10246 det the,lung
R7494 T10246 T10244 pobj lung,in
R7495 T10247 T10249 punct ",",analyzed
R7496 T10248 T10249 nsubj we,analyzed
R7497 T10249 T10249 ROOT analyzed,analyzed
R7498 T10250 T10251 det the,levels
R7499 T10251 T10249 dobj levels,analyzed
R7500 T10252 T10251 prep of,levels
R7501 T10253 T10254 amod several,chemokines
R7504 T10256 T10254 conj cytokines,chemokines
R7505 T10257 T10251 prep in,levels
R7506 T10258 T10260 det the,lavage
R7507 T10259 T10260 compound bronchoalveolar,lavage
R7508 T10260 T10257 pobj lavage,in
R7509 T10261 T10260 punct (,lavage
R7510 T10262 T10260 appos BAL,lavage
R7511 T10263 T10260 punct ),lavage
R7512 T10264 T10249 prep at,analyzed
R7513 T10265 T10264 pobj day,at
R7514 T10266 T10265 nummod 4,day
R7515 T10267 T10249 punct ",",analyzed
R7516 T10268 T10270 nummod 7,day
R7517 T10269 T10268 cc and,7
R7518 T10270 T10272 npadvmod day,following
R7519 T10271 T10272 nummod 10,following
R7520 T10272 T10249 advcl following,analyzed
R7521 T10273 T10272 dobj infection,following
R7522 T10274 T10249 punct .,analyzed
R7523 T10275 T10286 nsubj Levels,were
R7524 T10276 T10275 prep of,Levels
R7525 T10277 T10280 nmod KC,chemokines
R7526 T10278 T10277 cc and,KC
R7527 T10279 T10277 conj MIP-2,KC
R7528 T10280 T10276 pobj chemokines,of
R7529 T10281 T10275 punct ",",Levels
R7530 T10282 T10284 advmod as,as
R7531 T10283 T10284 advmod well,as
R7532 T10284 T10275 cc as,Levels
R7533 T10285 T10275 conj IL-6,Levels
R7534 T10286 T10286 ROOT were,were
R7535 T10287 T10288 advmod significantly,higher
R7536 T10288 T10286 acomp higher,were
R7537 T10289 T10286 prep at,were
R7538 T10290 T10289 pobj day,at
R7539 T10291 T10292 nummod 7,p.i.
R7540 T10292 T10286 npadvmod p.i.,were
R7541 T10293 T10292 prep in,p.i.
R7542 T10294 T10293 pobj BAL,in
R7543 T10295 T10292 prep from,p.i.
R7544 T10296 T10295 pobj IAV,from
R7545 T10297 T10286 conj infected,were
R7546 T10298 T10299 amod A20myel-KO,mice
R7547 T10299 T10297 dobj mice,infected
R7548 T10300 T10299 acl compared,mice
R7549 T10301 T10300 prep to,compared
R7550 T10302 T10301 pobj IAV,to
R7551 T10303 T10306 amod infected,mice
R7552 T10304 T10306 amod wild,mice
R7553 T10305 T10306 compound type,mice
R7554 T10306 T10302 dobj mice,IAV
R7555 T10307 T10308 punct (,figure
R7556 T10308 T10306 parataxis figure,mice
R7557 T10309 T10308 dobj 3C,figure
R7558 T10310 T10308 punct ),figure
R7559 T10311 T10286 punct .,were
R7560 T10312 T10318 prep Unlike,stimulated
R7561 T10313 T10314 poss our,observations
R7562 T10314 T10312 pobj observations,Unlike
R7563 T10315 T10314 prep with,observations
R7564 T10316 T10317 nmod in,vitro
R7565 T10317 T10318 nsubj vitro,stimulated
R7566 T10318 T10318 ROOT stimulated,stimulated
R7567 T10319 T10320 amod primary,macrophages
R7568 T10320 T10318 dobj macrophages,stimulated
R7569 T10321 T10324 nsubj we,detect
R7570 T10322 T10324 aux could,detect
R7571 T10323 T10324 neg not,detect
R7572 T10324 T10318 ccomp detect,stimulated
R7573 T10325 T10327 det a,increase
R7574 T10326 T10327 amod significant,increase
R7575 T10327 T10324 dobj increase,detect
R7576 T10328 T10327 prep in,increase
R7577 T10329 T10328 pobj MCP-1,in
R7578 T10330 T10329 cc or,MCP-1
R7579 T10331 T10329 conj IFNα,MCP-1
R7580 T10332 T10327 conj production,increase
R7581 T10333 T10327 prep in,increase
R7582 T10334 T10335 det the,lungs
R7583 T10335 T10333 pobj lungs,in
R7584 T10336 T10335 prep of,lungs
R7585 T10337 T10338 amod A20myel-KO,animals
R7586 T10338 T10336 pobj animals,of
R7587 T10339 T10341 punct (,3C
R7588 T10340 T10341 compound figure,3C
R7589 T10341 T10327 appos 3C,increase
R7590 T10342 T10341 punct ),3C
R7591 T10343 T10318 punct .,stimulated
R7592 T10344 T10345 nsubj KC,is
R7593 T10345 T10345 ROOT is,is
R7594 T10346 T10348 det the,orthologue
R7595 T10347 T10348 compound murine,orthologue
R7596 T10348 T10345 attr orthologue,is
R7597 T10349 T10348 prep of,orthologue
R7598 T10350 T10349 pobj IL-8,of
R7599 T10351 T10345 cc and,is
R7600 T10352 T10345 conj serves,is
R7601 T10353 T10354 advmod together,with
R7602 T10354 T10352 prep with,serves
R7603 T10355 T10354 pobj MIP-2,with
R7604 T10356 T10352 prep as,serves
R7605 T10357 T10358 det a,chemoattractant
R7606 T10358 T10356 pobj chemoattractant,as
R7607 T10359 T10358 prep for,chemoattractant
R7608 T10360 T10359 pobj neutrophils,for
R7609 T10361 T10352 punct ",",serves
R7610 T10362 T10366 mark while,known
R7611 T10363 T10366 nsubjpass MCP-1,known
R7612 T10364 T10366 auxpass is,known
R7613 T10365 T10366 advmod mainly,known
R7614 T10366 T10352 advcl known,serves
R7615 T10367 T10366 prep as,known
R7616 T10368 T10369 det a,chemoattractant
R7617 T10369 T10367 pobj chemoattractant,as
R7618 T10370 T10369 prep for,chemoattractant
R7619 T10371 T10370 pobj monocytes,for
R7620 T10372 T10371 punct ",",monocytes
R7621 T10373 T10375 nsubj which,develop
R7622 T10374 T10375 advmod eventually,develop
R7623 T10375 T10371 relcl develop,monocytes
R7624 T10376 T10375 prep into,develop
R7625 T10377 T10376 pobj macrophages,into
R7626 T10378 T10375 prep upon,develop
R7627 T10379 T10378 pcomp entering,upon
R7628 T10380 T10382 det the,lumen
R7629 T10381 T10382 amod alveolar,lumen
R7630 T10382 T10379 dobj lumen,entering
R7631 T10383 T10385 nmod [,]
R7632 T10384 T10385 nummod 60,]
R7633 T10385 T10379 dobj ],entering
R7634 T10386 T10345 punct .,is
R7635 T10387 T10394 amod Consistent,levels
R7636 T10388 T10387 prep with,Consistent
R7637 T10389 T10391 det the,KC
R7638 T10390 T10391 amod higher,KC
R7639 T10391 T10388 pobj KC,with
R7640 T10392 T10391 cc and,KC
R7641 T10393 T10394 compound MIP-2,levels
R7642 T10394 T10423 nsubj levels,was
R7643 T10395 T10394 prep in,levels
R7644 T10396 T10397 amod A20myel-KO,mice
R7645 T10397 T10395 pobj mice,in
R7646 T10398 T10423 punct ",",was
R7647 T10399 T10400 det the,number
R7648 T10400 T10423 nsubj number,was
R7649 T10401 T10400 prep of,number
R7650 T10402 T10401 pobj neutrophils,of
R7651 T10403 T10402 punct (,neutrophils
R7652 T10404 T10405 amod CD11b,+
R7653 T10405 T10411 compound +,−
R7654 T10406 T10411 compound Ly6C,−
R7655 T10463 T10463 ROOT was,was
R7656 T10407 T10411 compound +,−
R7657 T10464 T10463 neg not,was
R7658 T10465 T10463 acomp evident,was
R7659 T10466 T10463 prep at,was
R7660 T10408 T10411 compound Ly6G,−
R7661 T10467 T10468 advmod later,time
R7662 T10468 T10469 compound time,points
R7663 T10469 T10466 pobj points,at
R7664 T10409 T10411 compound +,−
R7665 T10470 T10463 prep after,was
R7666 T10471 T10470 pobj infection,after
R7667 T10472 T10473 punct (,figure
R7668 T10410 T10411 compound F4/80,−
R7669 T10473 T10463 advcl figure,was
R7670 T10474 T10473 npadvmod 3D,figure
R7671 T10475 T10474 punct ),3D
R7672 T10411 T10402 appos −,neutrophils
R7673 T10476 T10473 punct ",",figure
R7674 T10477 T10478 nsubj which,is
R7675 T10478 T10473 relcl is,figure
R7676 T10412 T10402 punct ),neutrophils
R7677 T10479 T10478 acomp consistent,is
R7678 T10480 T10479 prep with,consistent
R7679 T10481 T10483 det the,expression
R7680 T10482 T10483 amod equal,expression
R7681 T10413 T10415 nsubjpass that,recruited
R7682 T10483 T10480 pobj expression,with
R7683 T10484 T10483 prep of,expression
R7684 T10485 T10484 pobj MCP-1,of
R7685 T10414 T10415 auxpass were,recruited
R7686 T10486 T10478 prep in,is
R7687 T10487 T10488 det both,groups
R7688 T10488 T10486 pobj groups,in
R7689 T10415 T10400 relcl recruited,number
R7690 T10489 T10488 prep of,groups
R7691 T10490 T10489 pobj mice,of
R7692 T10416 T10415 prep in,recruited
R7693 T10417 T10419 det the,spaces
R7694 T10491 T10463 punct .,was
R7695 T10418 T10419 compound bronchoalveolar,spaces
R7696 T10492 T10493 det The,number
R7697 T10493 T10510 nsubjpass number,elevated
R7698 T10494 T10493 prep of,number
R7699 T10495 T10497 nmod resident,macrophages
R7700 T10496 T10497 compound alveolar,macrophages
R7701 T10497 T10494 pobj macrophages,of
R7702 T10498 T10497 punct (,macrophages
R7703 T10499 T10500 amod autofluorescent,+
R7704 T10419 T10416 pobj spaces,in
R7705 T10500 T10506 compound +,−
R7706 T10501 T10506 compound CD11c,−
R7707 T10420 T10415 prep upon,recruited
R7708 T10502 T10506 compound +,−
R7709 T10421 T10422 compound IAV,infection
R7710 T10503 T10506 compound F4/80,−
R7711 T10504 T10506 compound +,−
R7712 T10505 T10506 compound CD11b,−
R7713 T10422 T10420 pobj infection,upon
R7714 T10506 T10497 appos −,macrophages
R7715 T10507 T10497 punct ),macrophages
R7716 T10508 T10510 auxpass was,elevated
R7717 T10423 T10423 ROOT was,was
R7718 T10509 T10510 advmod also,elevated
R7719 T10510 T10510 ROOT elevated,elevated
R7720 T10511 T10510 prep in,elevated
R7721 T10424 T10423 advmod clearly,was
R7722 T10512 T10513 amod A20myel-KO,mice
R7723 T10513 T10511 pobj mice,in
R7724 T10514 T10510 cc but,elevated
R7725 T10425 T10423 acomp higher,was
R7726 T10515 T10517 aux did,differ
R7727 T10516 T10517 neg not,differ
R7728 T10517 T10510 conj differ,elevated
R7729 T10518 T10517 advmod significantly,differ
R7730 T10426 T10423 prep throughout,was
R7731 T10519 T10517 prep between,differ
R7732 T10520 T10521 compound IAV,infected
R7733 T10521 T10525 amod infected,mice
R7734 T10427 T10426 pobj infection,throughout
R7735 T10522 T10521 cc or,infected
R7736 T10523 T10521 conj mock,infected
R7737 T10524 T10525 amod infected,mice
R7738 T10428 T10427 prep in,infection
R7739 T10525 T10519 pobj mice,between
R7740 T10526 T10528 punct (,3D
R7741 T10527 T10528 compound figure,3D
R7742 T10429 T10430 amod A20myel-KO,mice
R7743 T10528 T10525 appos 3D,mice
R7744 T10529 T10525 punct ),mice
R7745 T10430 T10428 pobj mice,in
R7746 T10530 T10517 punct .,differ
R7747 T10531 T10536 nsubj Elimination,depends
R7748 T10532 T10531 prep of,Elimination
R7749 T10533 T10532 pobj IAV,of
R7750 T10534 T10535 amod infected,cells
R7751 T10535 T10531 conj cells,Elimination
R7752 T10536 T10536 ROOT depends,depends
R7753 T10431 T10423 prep compared,was
R7754 T10537 T10536 prep on,depends
R7755 T10538 T10540 det the,expansion
R7756 T10539 T10540 amod clonal,expansion
R7757 T10540 T10537 pobj expansion,on
R7758 T10432 T10433 aux to,control
R7759 T10541 T10540 prep of,expansion
R7760 T10433 T10431 xcomp control,compared
R7761 T10434 T10433 dobj animals,control
R7762 T10542 T10541 pobj virus,of
R7763 T10435 T10434 punct (,animals
R7764 T10543 T10548 amod specific,cells
R7765 T10544 T10548 amod cytotoxic,cells
R7766 T10545 T10548 nmod CD8,cells
R7767 T10436 T10437 compound figure,3D
R7768 T10546 T10548 nummod +,cells
R7769 T10547 T10548 compound T,cells
R7770 T10548 T10540 conj cells,expansion
R7771 T10549 T10540 punct (,expansion
R7772 T10437 T10434 appos 3D,animals
R7773 T10550 T10540 appos CTL,expansion
R7774 T10551 T10540 punct ),expansion
R7775 T10552 T10554 nmod [,]
R7776 T10438 T10434 punct ),animals
R7777 T10553 T10554 nummod 61,]
R7778 T10554 T10540 appos ],expansion
R7779 T10555 T10554 punct ",",]
R7780 T10439 T10423 punct .,was
R7781 T10556 T10558 nmod [,]
R7782 T10557 T10558 nummod 62,]
R7783 T10558 T10554 conj ],]
R7784 T10559 T10558 punct ",",]
R7785 T10440 T10443 mark Although,detect
R7786 T10441 T10443 nsubj we,detect
R7787 T10442 T10443 aux could,detect
R7788 T10443 T10463 advcl detect,was
R7789 T10444 T10446 det a,increase
R7790 T10560 T10558 conj [,]
R7791 T10561 T10562 nummod 63,]
R7792 T10562 T10558 conj ],]
R7793 T10445 T10446 amod significant,increase
R7794 T10563 T10536 punct .,depends
R7795 T10564 T10565 aux To,test
R7796 T10446 T10443 dobj increase,detect
R7797 T10565 T10572 csubj test,regulates
R7798 T10566 T10572 mark whether,regulates
R7799 T10567 T10568 compound A20,expression
R7800 T10568 T10572 nsubj expression,regulates
R7801 T10569 T10568 prep in,expression
R7802 T10570 T10571 amod myeloid,cells
R7803 T10447 T10446 prep in,increase
R7804 T10571 T10569 pobj cells,in
R7805 T10572 T10572 ROOT regulates,regulates
R7806 T10573 T10576 det the,response
R7807 T10574 T10576 amod antiviral,response
R7808 T10448 T10447 pobj monocyte,in
R7809 T10575 T10576 compound CTL,response
R7810 T10576 T10572 dobj response,regulates
R7811 T10577 T10572 punct ",",regulates
R7812 T10578 T10582 amod total,cells
R7813 T10449 T10455 punct (,recruitment
R7814 T10579 T10582 compound CD8,cells
R7815 T10450 T10451 amod CD11b,+
R7816 T10580 T10582 nummod +,cells
R7817 T10581 T10582 compound T,cells
R7818 T10451 T10455 nmod +,recruitment
R7819 T10582 T10572 conj cells,regulates
R7820 T10583 T10582 cc and,cells
R7821 T10584 T10582 conj virus,cells
R7822 T10452 T10453 compound Ly6C,+
R7823 T10585 T10593 amod specific,expressing
R7824 T10586 T10587 compound Granzyme,B
R7825 T10587 T10593 nsubj B,expressing
R7826 T10453 T10451 appos +,+
R7827 T10588 T10587 punct (,B
R7828 T10589 T10587 appos GrB,B
R7829 T10454 T10451 punct ),+
R7830 T10590 T10589 punct ),GrB
R7831 T10591 T10587 cc and,B
R7832 T10592 T10587 conj IFNγ,B
R7833 T10455 T10446 appos recruitment,increase
R7834 T10593 T10572 advcl expressing,regulates
R7835 T10594 T10597 nummod CD8,cells
R7836 T10595 T10597 nummod +,cells
R7837 T10456 T10455 prep at,recruitment
R7838 T10596 T10597 compound T,cells
R7839 T10597 T10599 nsubjpass cells,measured
R7840 T10598 T10599 auxpass were,measured
R7841 T10457 T10460 nmod day,infection
R7842 T10599 T10593 ccomp measured,expressing
R7843 T10600 T10599 prep in,measured
R7844 T10601 T10600 pobj BAL,in
R7845 T10458 T10457 nummod 4,day
R7846 T10602 T10601 cc and,BAL
R7847 T10603 T10604 compound lung,parenchyma
R7848 T10604 T10599 dobj parenchyma,measured
R7849 T10605 T10604 prep of,parenchyma
R7850 T10606 T10607 amod wild,type
R7851 T10607 T10605 pobj type,of
R7852 T10608 T10607 cc and,type
R7853 T10459 T10460 compound post,infection
R7854 T10609 T10610 amod A20myel-KO,mice
R7855 T10610 T10607 conj mice,type
R7856 T10611 T10572 punct .,regulates
R7857 T10612 T10614 det A,increase
R7858 T10460 T10456 pobj infection,at
R7859 T10613 T10614 amod clear,increase
R7860 T10614 T10622 nsubjpass increase,detected
R7861 T10615 T10614 prep in,increase
R7862 T10616 T10619 nummod CD8,cells
R7863 T10461 T10463 punct ",",was
R7864 T10617 T10619 nummod +,cells
R7865 T10618 T10619 compound T,cells
R7866 T10619 T10615 pobj cells,in
R7867 T10462 T10463 nsubj this,was
R7868 T10620 T10622 aux could,detected
R7869 T10621 T10622 auxpass be,detected
R7870 T10622 T10622 ROOT detected,detected
R7871 T10623 T10622 prep at,detected
R7872 T10657 T10658 compound IFNγ,CD8
R7873 T10624 T10623 pobj day,at
R7874 T10625 T10624 nummod 7,day
R7875 T10658 T10655 conj CD8,GrB
R7876 T10626 T10622 cc and,detected
R7877 T10627 T10629 nummod 10,infection
R7878 T10628 T10629 compound post,infection
R7879 T10629 T10622 conj infection,detected
R7880 T10630 T10622 punct ",",detected
R7881 T10631 T10622 cc but,detected
R7882 T10632 T10633 det no,differences
R7883 T10659 T10673 ccomp +,altered
R7884 T10633 T10635 nsubjpass differences,observed
R7885 T10634 T10635 auxpass were,observed
R7886 T10635 T10622 conj observed,detected
R7887 T10660 T10661 compound T,cells
R7888 T10636 T10635 prep between,observed
R7889 T10637 T10641 amod A20myel-KO,mice
R7890 T10638 T10637 cc and,A20myel-KO
R7891 T10639 T10637 conj wild,A20myel-KO
R7892 T10661 T10659 dobj cells,+
R7893 T10640 T10641 compound type,mice
R7894 T10641 T10636 pobj mice,between
R7895 T10642 T10641 punct (,mice
R7896 T10662 T10664 advmod as,as
R7897 T10643 T10648 dobj figure,)
R7898 T10644 T10648 nmod S2A,)
R7899 T10645 T10644 cc and,S2A
R7900 T10646 T10647 compound figure,S2C
R7901 T10647 T10644 conj S2C,S2A
R7902 T10648 T10641 punct ),mice
R7903 T10649 T10635 punct .,observed
R7904 T10663 T10664 advmod well,as
R7905 T10650 T10673 advmod Also,altered
R7906 T10651 T10673 punct ",",altered
R7907 T10652 T10653 det the,number
R7908 T10653 T10659 nsubj number,+
R7909 T10664 T10661 cc as,cells
R7910 T10654 T10653 prep of,number
R7911 T10655 T10654 pobj GrB,of
R7912 T10656 T10655 cc and,GrB
R7913 T10665 T10667 compound IFNγ,levels
R7914 T10666 T10667 compound expression,levels
R7915 T10667 T10661 conj levels,cells
R7916 T10668 T10667 prep in,levels
R7917 T10754 T10755 amod humoral,immunity
R7918 T10755 T10758 nsubjpass immunity,affected
R7919 T10756 T10758 auxpass is,affected
R7920 T10669 T10670 det the,lungs
R7921 T10757 T10758 neg not,affected
R7922 T10758 T10752 ccomp affected,indicating
R7923 T10759 T10758 agent by,affected
R7924 T10670 T10668 pobj lungs,in
R7925 T10760 T10761 compound A20,expression
R7926 T10761 T10759 pobj expression,by
R7927 T10762 T10761 prep in,expression
R7928 T10671 T10673 auxpass were,altered
R7929 T10763 T10764 amod myeloid,cells
R7930 T10764 T10762 pobj cells,in
R7931 T10765 T10740 punct .,detected
R7932 T10672 T10673 neg not,altered
R7933 T10766 T10770 advmod Together,suggest
R7934 T10767 T10770 punct ",",suggest
R7935 T10768 T10769 det these,data
R7936 T10673 T10673 ROOT altered,altered
R7937 T10769 T10770 nsubj data,suggest
R7938 T10770 T10770 ROOT suggest,suggest
R7939 T10771 T10800 mark that,contribute
R7940 T10772 T10800 nsubj mechanisms,contribute
R7941 T10674 T10673 agent by,altered
R7942 T10773 T10772 amod other,mechanisms
R7943 T10774 T10773 prep than,other
R7944 T10775 T10776 amod adaptive,immunity
R7945 T10675 T10676 det the,absence
R7946 T10776 T10774 pobj immunity,than
R7947 T10777 T10772 punct ",",mechanisms
R7948 T10778 T10779 amod such,as
R7949 T10779 T10772 prep as,mechanisms
R7950 T10780 T10784 det an,response
R7951 T10781 T10784 amod increased,response
R7952 T10676 T10674 pobj absence,by
R7953 T10782 T10784 amod innate,response
R7954 T10783 T10784 amod immune,response
R7955 T10784 T10779 pobj response,as
R7956 T10785 T10784 punct ",",response
R7957 T10677 T10676 prep of,absence
R7958 T10786 T10784 acl characterized,response
R7959 T10787 T10786 agent by,characterized
R7960 T10788 T10790 det an,influx
R7961 T10678 T10677 pobj A20,of
R7962 T10789 T10790 amod increased,influx
R7963 T10790 T10787 pobj influx,by
R7964 T10791 T10790 prep of,influx
R7965 T10679 T10676 prep in,absence
R7966 T10792 T10791 pobj neutrophils,of
R7967 T10793 T10790 cc and,influx
R7968 T10794 T10795 amod increased,numbers
R7969 T10680 T10681 amod myeloid,cells
R7970 T10795 T10790 conj numbers,influx
R7971 T10796 T10795 prep of,numbers
R7972 T10797 T10798 amod alveolar,macrophages
R7973 T10798 T10796 pobj macrophages,of
R7974 T10681 T10679 pobj cells,in
R7975 T10799 T10800 punct ",",contribute
R7976 T10800 T10770 ccomp contribute,suggest
R7977 T10801 T10800 prep to,contribute
R7978 T10682 T10685 punct (,C
R7979 T10802 T10805 det the,clearance
R7980 T10803 T10805 amod better,clearance
R7981 T10804 T10805 amod viral,clearance
R7982 T10683 T10685 nsubj figure,C
R7983 T10805 T10801 pobj clearance,to
R7984 T10806 T10805 prep in,clearance
R7985 T10807 T10808 amod A20myel-KO,mice
R7986 T10808 T10806 pobj mice,in
R7987 T10684 T10685 dep S2A,C
R7988 T10809 T10770 punct .,suggest
R7989 T10810 T10813 nsubjpass It,believed
R7990 T10811 T10813 auxpass is,believed
R7991 T10685 T10673 npadvmod C,altered
R7992 T10812 T10813 advmod generally,believed
R7993 T10813 T10813 ROOT believed,believed
R7994 T10814 T10817 mark that,is
R7995 T10686 T10685 punct ),C
R7996 T10687 T10673 punct .,altered
R7997 T10815 T10816 amod IAV-induced,mortality
R7998 T10688 T10694 nsubjpass Protection,provided
R7999 T10816 T10817 nsubj mortality,is
R8000 T10817 T10813 ccomp is,believed
R8001 T10818 T10817 acomp due,is
R8002 T10819 T10818 prep to,due
R8003 T10820 T10823 det an,response
R8004 T10689 T10688 prep against,Protection
R8005 T10821 T10823 amod excessive,response
R8006 T10822 T10823 amod proinflammatory,response
R8007 T10823 T10819 pobj response,to
R8008 T10690 T10691 compound IAV,infection
R8009 T10824 T10823 prep in,response
R8010 T10825 T10826 det the,lung
R8011 T10826 T10824 pobj lung,in
R8012 T10691 T10689 pobj infection,against
R8013 T10827 T10813 punct .,believed
R8014 T10828 T10830 nsubj We,analyzed
R8015 T10829 T10830 advmod therefore,analyzed
R8016 T10830 T10830 ROOT analyzed,analyzed
R8017 T10692 T10694 auxpass is,provided
R8018 T10831 T10845 mark whether,affects
R8019 T10832 T10836 det the,production
R8020 T10833 T10836 amod increased,production
R8021 T10693 T10694 advmod also,provided
R8022 T10834 T10836 amod proinflammatory,production
R8023 T10835 T10836 compound cytokine,production
R8024 T10836 T10845 nsubj production,affects
R8025 T10694 T10694 ROOT provided,provided
R8026 T10837 T10836 cc and,production
R8027 T10838 T10836 conj infiltration,production
R8028 T10839 T10838 prep of,infiltration
R8029 T10840 T10841 amod proinflammatory,cells
R8030 T10695 T10694 agent by,provided
R8031 T10841 T10839 pobj cells,of
R8032 T10842 T10836 prep in,production
R8033 T10696 T10699 det the,response
R8034 T10843 T10844 amod A20myel-KO,mice
R8035 T10844 T10842 pobj mice,in
R8036 T10845 T10830 ccomp affects,analyzed
R8037 T10697 T10699 amod humoral,response
R8038 T10846 T10845 dobj mortality,affects
R8039 T10847 T10846 acl induced,mortality
R8040 T10848 T10847 agent by,induced
R8041 T10849 T10850 amod intranasal,infection
R8042 T10698 T10699 amod immune,response
R8043 T10850 T10848 pobj infection,by
R8044 T10699 T10695 pobj response,by
R8045 T10700 T10694 punct .,provided
R8046 T10701 T10702 aux To,test
R8047 T10851 T10847 prep with,induced
R8048 T10702 T10717 advcl test,determined
R8049 T10852 T10854 det a,dose
R8050 T10853 T10854 amod lethal,dose
R8051 T10854 T10851 pobj dose,with
R8052 T10855 T10854 prep of,dose
R8053 T10856 T10857 compound IAV,X-47
R8054 T10703 T10710 mark whether,affects
R8055 T10857 T10855 pobj X-47,of
R8056 T10858 T10830 punct .,analyzed
R8057 T10859 T10865 advmod Surprisingly,survived
R8058 T10860 T10865 punct ",",survived
R8059 T10704 T10710 nsubj loss,affects
R8060 T10861 T10862 advmod almost,all
R8061 T10862 T10864 nummod all,mice
R8062 T10863 T10864 amod A20myel-KO,mice
R8063 T10864 T10865 nsubj mice,survived
R8064 T10705 T10704 prep of,loss
R8065 T10865 T10865 ROOT survived,survived
R8066 T10866 T10867 punct (,10/11
R8067 T10867 T10865 parataxis 10/11,survived
R8068 T10706 T10705 pobj A20,of
R8069 T10868 T10867 punct ),10/11
R8070 T10869 T10865 punct ",",survived
R8071 T10870 T10874 mark while,succumbed
R8072 T10871 T10873 det all,mice
R8073 T10707 T10704 prep in,loss
R8074 T10872 T10873 compound control,mice
R8075 T10873 T10874 nsubj mice,succumbed
R8076 T10874 T10865 advcl succumbed,survived
R8077 T10708 T10709 amod myeloid,cells
R8078 T10875 T10874 punct (,succumbed
R8079 T10876 T10874 npadvmod 0/11,succumbed
R8080 T10877 T10874 punct ),succumbed
R8081 T10878 T10874 prep within,succumbed
R8082 T10709 T10707 pobj cells,in
R8083 T10879 T10880 nummod 16,days
R8084 T10880 T10878 pobj days,within
R8085 T10881 T10874 prep after,succumbed
R8086 T10710 T10717 advcl affects,determined
R8087 T10882 T10885 compound infection,4A
R8088 T10883 T10884 punct (,figure
R8089 T10884 T10885 compound figure,4A
R8090 T10885 T10881 pobj 4A,after
R8091 T10711 T10712 compound B,cell
R8092 T10886 T10874 punct ),succumbed
R8093 T10887 T10865 punct .,survived
R8094 T10888 T10889 amod A20myel-KO,mice
R8095 T10712 T10713 nsubj cell,mediated
R8096 T10889 T10891 nsubj mice,showed
R8097 T10890 T10891 advmod still,showed
R8098 T10891 T10920 ccomp showed,were
R8099 T10713 T10714 amod mediated,immunity
R8100 T10892 T10894 amod significant,loss
R8101 T10893 T10894 compound weight,loss
R8102 T10714 T10710 dobj immunity,affects
R8103 T10894 T10891 dobj loss,showed
R8104 T10895 T10894 cc and,loss
R8105 T10896 T10897 compound lung,damage
R8106 T10715 T10717 punct ",",determined
R8107 T10897 T10894 conj damage,loss
R8108 T10898 T10900 punct (,reflected
R8109 T10899 T10900 mark as,reflected
R8110 T10716 T10717 nsubj we,determined
R8111 T10900 T10920 advcl reflected,were
R8112 T10717 T10717 ROOT determined,determined
R8113 T10901 T10900 agent by,reflected
R8114 T10902 T10905 amod increased,concentration
R8115 T10718 T10717 dobj hemagglutinin,determined
R8116 T10903 T10905 amod total,concentration
R8117 T10904 T10905 compound protein,concentration
R8118 T10905 T10901 pobj concentration,by
R8119 T10719 T10723 punct (,titers
R8120 T10906 T10905 prep in,concentration
R8121 T10907 T10908 det the,BAL
R8122 T10720 T10723 compound HA,titers
R8123 T10721 T10722 punct ),antibody
R8124 T10908 T10906 pobj BAL,in
R8125 T10722 T10723 compound antibody,titers
R8126 T10909 T10920 punct ;,were
R8127 T10910 T10920 nsubj data,were
R8128 T10911 T10912 neg not,shown
R8129 T10723 T10718 appos titers,hemagglutinin
R8130 T10912 T10910 acl shown,data
R8131 T10913 T10912 punct ),shown
R8132 T10914 T10910 prep during,data
R8133 T10724 T10723 prep in,titers
R8134 T10915 T10916 det the,course
R8135 T10916 T10914 pobj course,during
R8136 T10917 T10916 prep of,course
R8137 T10725 T10726 det the,serum
R8138 T10918 T10917 pobj infection,of
R8139 T10919 T10910 cc but,data
R8140 T10920 T10920 ROOT were,were
R8141 T10726 T10724 pobj serum,in
R8142 T10921 T10920 acomp able,were
R8143 T10922 T10923 aux to,recover
R8144 T10923 T10921 xcomp recover,able
R8145 T10924 T10920 punct ",",were
R8146 T10727 T10726 prep of,serum
R8147 T10925 T10920 prep in,were
R8148 T10926 T10925 pobj contrast,in
R8149 T10927 T10926 prep to,contrast
R8150 T10728 T10731 amod A20myel-KO,type
R8151 T10928 T10930 amod wild,mice
R8152 T10929 T10930 compound type,mice
R8153 T10930 T10927 pobj mice,to
R8154 T10931 T10932 nsubj that,succumbed
R8155 T10932 T10930 relcl succumbed,mice
R8156 T10729 T10728 cc and,A20myel-KO
R8157 T10933 T10935 punct (,4B
R8158 T10934 T10935 compound figure,4B
R8159 T10935 T10932 dobj 4B,succumbed
R8160 T10936 T10935 punct ),4B
R8161 T10937 T10920 punct .,were
R8162 T10730 T10728 conj wild,A20myel-KO
R8163 T10938 T10952 nsubj Similar,was
R8164 T10939 T10938 prep to,Similar
R8165 T10940 T10941 poss our,observations
R8166 T10731 T10732 compound type,littermates
R8167 T10941 T10939 pobj observations,to
R8168 T10942 T10938 prep with,Similar
R8169 T10943 T10945 amod sublethal,infection
R8170 T10944 T10945 compound IAV,infection
R8171 T10732 T10727 pobj littermates,of
R8172 T10945 T10942 pobj infection,with
R8173 T10946 T10945 punct ",",infection
R8174 T10947 T10948 amod pulmonary,KC
R8175 T10733 T10717 punct .,determined
R8176 T10734 T10740 advmod However,detected
R8177 T10735 T10740 punct ",",detected
R8178 T10948 T10952 nsubj KC,was
R8179 T10949 T10948 cc and,KC
R8180 T10736 T10737 det no,differences
R8181 T10950 T10951 compound MIP-2,production
R8182 T10951 T10948 conj production,KC
R8183 T10952 T10952 ROOT was,was
R8184 T10953 T10952 acomp stronger,was
R8185 T10737 T10740 nsubjpass differences,detected
R8186 T10954 T10953 prep in,stronger
R8187 T10955 T10956 amod A20myel-KO,animals
R8188 T10956 T10954 pobj animals,in
R8189 T10738 T10740 aux could,detected
R8190 T10957 T10952 prep compared,was
R8191 T10958 T10957 prep to,compared
R8192 T10959 T10961 amod wild,mice
R8193 T10739 T10740 auxpass be,detected
R8194 T10960 T10961 compound type,mice
R8195 T10961 T10958 pobj mice,to
R8196 T10962 T10961 acl following,mice
R8197 T10740 T10740 ROOT detected,detected
R8198 T10963 T10965 amod lethal,infection
R8199 T10964 T10965 compound IAV,infection
R8200 T10965 T10962 dobj infection,following
R8201 T10966 T10968 punct (,4C
R8202 T10967 T10968 compound figure,4C
R8203 T10968 T10965 appos 4C,infection
R8204 T10741 T10740 prep between,detected
R8205 T10969 T10968 punct ),4C
R8206 T10970 T10968 punct ",",4C
R8207 T10742 T10743 amod wild,type
R8208 T10971 T10972 nsubj which,correlates
R8209 T10743 T10741 pobj type,between
R8210 T10972 T10968 relcl correlates,4C
R8211 T10973 T10972 prep with,correlates
R8212 T10974 T10976 det the,numbers
R8213 T10975 T10976 amod increased,numbers
R8214 T10744 T10743 cc and,type
R8215 T10976 T10973 pobj numbers,with
R8216 T10977 T10976 prep of,numbers
R8217 T10978 T10977 pobj neutrophils,of
R8218 T10745 T10746 amod A20myel-KO,animals
R8219 T10979 T10978 prep in,neutrophils
R8220 T10980 T10981 det the,lungs
R8221 T10746 T10743 conj animals,type
R8222 T10981 T10979 pobj lungs,in
R8223 T10982 T10981 prep of,lungs
R8224 T10983 T10984 det these,mice
R8225 T10984 T10982 pobj mice,of
R8226 T10747 T10749 punct (,S2D
R8227 T10985 T10987 punct (,4C
R8228 T10986 T10987 compound figure,4C
R8229 T10748 T10749 compound figure,S2D
R8230 T10987 T10976 appos 4C,numbers
R8231 T10988 T10987 punct ),4C
R8232 T10989 T10952 punct .,was
R8233 T10990 T11015 advmod Also,increased
R8234 T10749 T10746 appos S2D,animals
R8235 T10991 T11015 nsubjpass levels,increased
R8236 T10992 T10991 prep of,levels
R8237 T10993 T10995 det the,cytokines
R8238 T10750 T10746 punct ),animals
R8239 T10994 T10995 amod proinflammatory,cytokines
R8240 T10995 T10992 pobj cytokines,of
R8241 T10996 T11015 nsubjpass IL-6,increased
R8242 T10751 T10740 punct ",",detected
R8243 T10997 T10996 punct ",",IL-6
R8244 T10998 T10996 conj TNF,IL-6
R8245 T10999 T10998 cc and,TNF
R8246 T10752 T10740 advcl indicating,detected
R8247 T11000 T10998 conj IL-1β,TNF
R8248 T11001 T11000 punct ",",IL-1β
R8249 T11002 T11005 nsubjpass which,associated
R8250 T10753 T10758 mark that,affected
R8251 T11003 T11005 auxpass are,associated
R8252 T11004 T11005 advmod often,associated
R8253 T11005 T10996 relcl associated,IL-6
R8254 T11006 T11005 prep with,associated
R8255 T11007 T11006 pobj immunopathogenesis,with
R8256 T11008 T11007 prep in,immunopathogenesis
R8257 T11042 T11043 advmod even,lower
R8258 T11009 T11008 pobj humans,in
R8259 T11010 T11012 nmod [,]
R8260 T11011 T11012 nummod 64,]
R8261 T11012 T11007 appos ],immunopathogenesis
R8262 T11013 T11015 punct ",",increased
R8263 T11014 T11015 auxpass were,increased
R8264 T11043 T11040 conj lower,increased
R8265 T11015 T11015 ROOT increased,increased
R8266 T11016 T11015 prep in,increased
R8267 T11017 T11018 det the,lungs
R8268 T11044 T11043 prep in,lower
R8269 T11018 T11016 pobj lungs,in
R8270 T11019 T11018 prep of,lungs
R8271 T11020 T11021 amod A20myel-KO,mice
R8272 T11045 T11046 amod A20myel-KO,mice
R8273 T11021 T11019 pobj mice,of
R8274 T11022 T11015 prep compared,increased
R8275 T11023 T11024 aux to,control
R8276 T11024 T11022 xcomp control,compared
R8277 T11046 T11044 pobj mice,in
R8278 T11025 T11024 dobj animals,control
R8279 T11026 T11025 punct (,animals
R8280 T11027 T11028 compound figure,4C
R8281 T11047 T11049 punct (,4C
R8282 T11028 T11025 appos 4C,animals
R8283 T11029 T11028 cc and,4C
R8284 T11030 T11031 compound figure,S3A
R8285 T11031 T11028 conj S3A,4C
R8286 T11048 T11049 compound figure,4C
R8287 T11032 T11031 punct ),S3A
R8288 T11033 T11015 punct .,increased
R8289 T11034 T11040 advmod Again,increased
R8290 T11035 T11040 punct ",",increased
R8291 T11049 T11046 appos 4C,mice
R8292 T11036 T11037 compound MCP-1,production
R8293 T11037 T11040 nsubjpass production,increased
R8294 T11038 T11040 auxpass was,increased
R8295 T11050 T11049 punct ),4C
R8296 T11039 T11040 neg not,increased
R8297 T11040 T11040 ROOT increased,increased
R8298 T11041 T11040 cc and,increased
R8299 T11051 T11043 punct ",",lower
R8300 T11052 T11043 cc and,lower
R8301 T11077 T11078 amod adaptive,immunity
R8302 T11053 T11056 advmod also,was
R8303 T11054 T11055 amod monocyte,recruitment
R8304 T11078 T11074 conj immunity,clearance
R8305 T11055 T11056 nsubj recruitment,was
R8306 T11056 T11040 conj was,increased
R8307 T11079 T11078 prep at,immunity
R8308 T11057 T11056 neg not,was
R8309 T11058 T11056 acomp different,was
R8310 T11059 T11058 prep between,different
R8311 T11080 T11083 nummod 6,infection
R8312 T11060 T11061 det both,groups
R8313 T11061 T11059 pobj groups,between
R8314 T11062 T11061 prep of,groups
R8315 T11063 T11062 pobj mice,of
R8316 T11081 T11082 compound h,post
R8317 T11064 T11056 punct .,was
R8318 T11065 T11069 nsubj We,detect
R8319 T11066 T11069 aux could,detect
R8320 T11082 T11083 compound post,infection
R8321 T11067 T11069 advmod also,detect
R8322 T11068 T11069 neg not,detect
R8323 T11069 T11069 ROOT detect,detect
R8324 T11083 T11079 pobj infection,at
R8325 T11070 T11071 det any,differences
R8326 T11071 T11069 dobj differences,detect
R8327 T11072 T11071 prep in,differences
R8328 T11084 T11085 punct (,figure
R8329 T11073 T11074 amod viral,clearance
R8330 T11085 T11069 parataxis figure,detect
R8331 T11074 T11072 pobj clearance,in
R8332 T11075 T11074 cc or,clearance
R8333 T11076 T11078 amod antiviral,immunity
R8334 T11086 T11085 nummod S3B,figure
R8335 T11087 T11085 appos F,figure
R8336 T11088 T11085 punct ),figure
R8337 T11089 T11069 punct .,detect
R8338 T11090 T11093 advmod Collectively,indicate
R8339 T11091 T11092 det these,data
R8340 T11092 T11093 nsubj data,indicate
R8341 T11093 T11093 ROOT indicate,indicate
R8342 T11094 T11101 mark that,associated
R8343 T11095 T11096 nummod A20,deficiency
R8344 T11096 T11101 nsubjpass deficiency,associated
R8345 T11097 T11096 prep in,deficiency
R8346 T11098 T11099 amod myeloid,cells
R8347 T11099 T11097 pobj cells,in
R8348 T11100 T11101 auxpass is,associated
R8349 T11101 T11093 ccomp associated,indicate
R8350 T11102 T11101 prep with,associated
R8351 T11103 T11107 det an,response
R8352 T11104 T11107 amod increased,response
R8353 T11105 T11107 amod innate,response
R8354 T11106 T11107 amod immune,response
R8355 T11107 T11102 pobj response,with
R8356 T11108 T11107 cc and,response
R8358 T11109 T11107 conj protection,response
R8359 T11110 T11107 prep against,response
R8361 T11111 T11114 det a,infection
R8363 T11112 T11114 amod lethal,infection
R8365 T11113 T11114 compound IAV,infection
R8367 T11114 T11110 pobj infection,against
R8370 T11115 T11093 punct .,indicate
R9674 T13111 T13117 prep In,investigated
R9675 T13112 T13114 det the,study
R9676 T13113 T13114 amod present,study
R9677 T13114 T13111 pobj study,In
R9678 T13115 T13117 nsubj we,investigated
R9679 T13116 T13117 aux have,investigated
R9680 T13117 T13117 ROOT investigated,investigated
R9681 T13118 T13119 det the,contribution
R9682 T13119 T13117 dobj contribution,investigated
R9683 T13120 T13119 prep of,contribution
R9684 T13121 T13122 compound A20,expression
R9685 T13122 T13120 pobj expression,of
R9686 T13123 T13122 prep in,expression
R9687 T13124 T13125 amod myeloid,cells
R9688 T13125 T13123 pobj cells,in
R9689 T13126 T13119 prep in,contribution
R9690 T13127 T13130 det the,response
R9691 T13128 T13130 amod innate,response
R9692 T13129 T13130 amod immune,response
R9693 T13130 T13126 pobj response,in
R9694 T13131 T13130 prep to,response
R9695 T13132 T13134 compound IAV,infection
R9696 T13133 T13134 compound lung,infection
R9697 T13134 T13131 pobj infection,to
R9698 T13135 T13117 punct .,investigated
R9699 T13136 T13142 prep In,populate
R9700 T13137 T13139 det the,environment
R9701 T13138 T13139 amod pulmonary,environment
R9702 T13139 T13136 pobj environment,In
R9703 T13140 T13142 punct ",",populate
R9704 T13141 T13142 nsubj macrophages,populate
R9705 T13142 T13142 ROOT populate,populate
R9706 T13143 T13145 det both,parenchyma
R9707 T13144 T13145 compound lung,parenchyma
R9708 T13145 T13142 dobj parenchyma,populate
R9709 T13146 T13145 cc and,parenchyma
R9710 T13147 T13149 det the,lumen
R9711 T13148 T13149 amod alveolar,lumen
R9712 T13149 T13145 conj lumen,parenchyma
R9713 T13150 T13153 advmod where,referred
R9714 T13151 T13153 nsubjpass they,referred
R9715 T13152 T13153 auxpass are,referred
R9716 T13153 T13149 relcl referred,lumen
R9717 T13154 T13153 prep to,referred
R9718 T13155 T13153 prep as,referred
R9719 T13156 T13157 amod alveolar,macrophages
R9720 T13157 T13155 pobj macrophages,as
R9721 T13158 T13142 punct .,populate
R9722 T13159 T13165 prep Under,exert
R9723 T13160 T13161 compound naïve,conditions
R9724 T13161 T13159 pobj conditions,Under
R9725 T13162 T13165 punct ",",exert
R9726 T13163 T13164 amod alveolar,macrophages
R9727 T13164 T13165 nsubj macrophages,exert
R9728 T13165 T13165 ROOT exert,exert
R9729 T13166 T13168 amod important,functions
R9730 T13167 T13168 amod immunomodulatory,functions
R9731 T13168 T13165 dobj functions,exert
R9732 T13169 T13171 nmod [,]
R9733 T13170 T13171 nummod 65,]
R9734 T13171 T13165 dep ],exert
R9735 T13172 T13171 punct ",",]
R9736 T13173 T13171 appos [,]
R9737 T13174 T13175 nummod 66,]
R9738 T13175 T13171 conj ],]
R9739 T13176 T13165 punct .,exert
R9740 T13177 T13181 advmod However,are
R9741 T13178 T13181 punct ",",are
R9742 T13179 T13180 amod alveolar,macrophages
R9743 T13180 T13181 nsubj macrophages,are
R9744 T13181 T13181 ROOT are,are
R9745 T13182 T13181 advmod also,are
R9746 T13183 T13181 acomp crucial,are
R9747 T13184 T13181 prep in,are
R9748 T13185 T13188 det the,response
R9749 T13186 T13188 amod innate,response
R9750 T13187 T13188 amod immune,response
R9751 T13188 T13184 pobj response,in
R9752 T13189 T13188 prep against,response
R9753 T13190 T13189 pobj IAV,against
R9754 T13191 T13193 mark as,are
R9755 T13192 T13193 nsubj they,are
R9756 T13193 T13181 advcl are,are
R9757 T13194 T13193 attr one,are
R9758 T13195 T13194 prep of,one
R9759 T13196 T13198 det the,cells
R9760 T13197 T13198 amod first,cells
R9761 T13198 T13195 pobj cells,of
R9762 T13199 T13200 nsubj that,encounter
R9763 T13200 T13198 relcl encounter,cells
R9764 T13201 T13203 amod infectious,particles
R9765 T13202 T13203 compound IAV,particles
R9766 T13203 T13200 dobj particles,encounter
R9767 T13204 T13206 nmod [,]
R9768 T13205 T13206 nummod 67,]
R9769 T13206 T13194 appos ],one
R9770 T13207 T13206 punct ",",]
R9771 T13208 T13206 conj [,]
R9772 T13209 T13210 nummod 68,]
R9773 T13210 T13206 conj ],]
R9774 T13211 T13181 punct .,are
R9775 T13212 T13213 nsubj They,are
R9776 T13213 T13213 ROOT are,are
R9777 T13214 T13216 det an,source
R9778 T13215 T13216 amod important,source
R9779 T13216 T13213 attr source,are
R9780 T13217 T13216 prep of,source
R9781 T13218 T13219 amod proinflammatory,cytokines
R9782 T13219 T13217 pobj cytokines,of
R9783 T13220 T13219 cc and,cytokines
R9784 T13221 T13219 conj chemokines,cytokines
R9785 T13222 T13223 nsubj that,attract
R9786 T13223 T13219 relcl attract,cytokines
R9787 T13224 T13226 amod innate,cells
R9788 T13225 T13226 amod immune,cells
R9789 T13226 T13223 dobj cells,attract
R9790 T13227 T13223 prep to,attract
R9791 T13228 T13229 det the,lung
R9792 T13229 T13227 pobj lung,to
R9793 T13230 T13223 prep during,attract
R9794 T13231 T13233 det the,phase
R9795 T13232 T13233 amod primary,phase
R9796 T13233 T13230 pobj phase,during
R9797 T13234 T13233 prep of,phase
R9798 T13235 T13234 pobj infection,of
R9799 T13236 T13238 nmod [,]
R9800 T13237 T13238 nummod 69,]
R9801 T13238 T13233 appos ],phase
R9802 T13239 T13213 punct ",",are
R9803 T13240 T13213 cc and,are
R9804 T13241 T13242 nsubj they,are
R9805 T13242 T13213 conj are,are
R9806 T13243 T13245 det the,producers
R9807 T13244 T13245 amod primary,producers
R9808 T13245 T13242 attr producers,are
R9809 T13246 T13245 prep of,producers
R9810 T13247 T13246 pobj type,of
R9811 T13248 T13249 nsubj I,IFNs
R9812 T13249 T13242 ccomp IFNs,are
R9813 T13250 T13252 nmod [,]
R9814 T13251 T13252 nummod 70,]
R9815 T13252 T13252 ROOT ],]
R9816 T13253 T13242 punct .,are
R9817 T13254 T13255 compound Alveolar,macrophages
R9818 T13255 T13258 nsubjpass macrophages,known
R9819 T13256 T13258 auxpass are,known
R9820 T13257 T13258 advmod also,known
R9821 T13258 T13258 ROOT known,known
R9822 T13259 T13260 aux to,phagocytose
R9823 T13260 T13258 xcomp phagocytose,known
R9824 T13261 T13264 nmod virus,cells
R9825 T13262 T13264 amod infected,cells
R9826 T13263 T13264 amod apoptotic,cells
R9827 T13264 T13260 dobj cells,phagocytose
R9828 T13265 T13264 cc and,cells
R9829 T13266 T13269 nmod antibody,particles
R9830 T13267 T13269 amod coated,particles
R9831 T13268 T13269 amod viral,particles
R9832 T13269 T13264 conj particles,cells
R9833 T13270 T13269 punct ",",particles
R9834 T13271 T13272 advmod further,contributing
R9835 T13272 T13264 acl contributing,cells
R9836 T13273 T13272 prep to,contributing
R9837 T13274 T13275 amod viral,clearance
R9838 T13275 T13273 pobj clearance,to
R9839 T13276 T13258 punct .,known
R9840 T13277 T13279 nsubj We,show
R9841 T13278 T13279 aux could,show
R9842 T13279 T13279 ROOT show,show
R9843 T13280 T13285 mark that,derived
R9844 T13281 T13285 nsubj BMDM,derived
R9845 T13282 T13281 cc or,BMDM
R9846 T13283 T13281 conj alveolar,BMDM
R9847 T13284 T13281 conj macrophages,BMDM
R9848 T13285 T13279 ccomp derived,show
R9849 T13286 T13285 prep from,derived
R9850 T13287 T13288 amod A20myel-KO,mice
R9851 T13288 T13286 pobj mice,from
R9852 T13289 T13285 conj express,derived
R9853 T13290 T13291 amod higher,amounts
R9854 T13291 T13289 dobj amounts,express
R9855 T13292 T13291 prep of,amounts
R9856 T13293 T13292 pobj chemokines,of
R9857 T13294 T13293 punct ",",chemokines
R9858 T13295 T13293 conj cytokines,chemokines
R9859 T13296 T13295 cc and,cytokines
R9860 T13297 T13295 conj type,cytokines
R9861 T13298 T13299 nsubj I,IFNs
R9862 T13299 T13279 conj IFNs,show
R9863 T13300 T13279 prep compared,show
R9864 T13301 T13300 prep to,compared
R9865 T13302 T13304 amod wild,mice
R9866 T13303 T13304 compound type,mice
R9867 T13304 T13301 pobj mice,to
R9868 T13305 T13304 prep in,mice
R9869 T13306 T13305 pobj response,in
R9870 T13307 T13306 prep to,response
R9871 T13308 T13306 prep in,response
R9872 T13309 T13310 amod vitro,infection
R9873 T13310 T13308 pobj infection,in
R9874 T13311 T13279 punct .,show
R9875 T13312 T13319 advmod Similarly,resulted
R9876 T13313 T13319 punct ",",resulted
R9877 T13314 T13319 prep in,resulted
R9878 T13315 T13316 compound vivo,infection
R9879 T13316 T13319 nsubj infection,resulted
R9880 T13317 T13316 prep with,infection
R9881 T13318 T13317 pobj IAV,with
R9882 T13319 T13319 ROOT resulted,resulted
R9883 T13320 T13319 prep in,resulted
R9884 T13321 T13322 amod higher,levels
R9885 T13322 T13320 pobj levels,in
R9886 T13323 T13322 prep of,levels
R9887 T13324 T13325 advmod primarily,neutrophil
R9888 T13325 T13323 pobj neutrophil,of
R9889 T13326 T13322 acl attracting,levels
R9890 T13327 T13326 dobj chemokines,attracting
R9891 T13328 T13329 amod such,as
R9892 T13329 T13327 prep as,chemokines
R9893 T13330 T13329 pobj KC,as
R9894 T13331 T13330 cc and,KC
R9895 T13332 T13330 conj MIP-2,KC
R9896 T13333 T13332 cc and,MIP-2
R9897 T13334 T13336 amod several,cytokines
R9898 T13335 T13336 amod proinflammatory,cytokines
R9899 T13336 T13332 conj cytokines,MIP-2
R9900 T13337 T13338 amod such,as
R9901 T13338 T13336 prep as,cytokines
R9902 T13339 T13338 pobj IL-6,as
R9903 T13340 T13339 punct ",",IL-6
R9904 T13341 T13339 conj TNF,IL-6
R9905 T13342 T13341 cc and,TNF
R9906 T13343 T13341 conj IL-1β,TNF
R9907 T13344 T13336 prep in,cytokines
R9908 T13345 T13346 det the,lungs
R9909 T13346 T13344 pobj lungs,in
R9910 T13347 T13346 prep of,lungs
R9911 T13348 T13349 amod A20myel-KO,mice
R9912 T13349 T13347 pobj mice,of
R9913 T13350 T13319 prep compared,resulted
R9914 T13351 T13350 prep to,compared
R9915 T13352 T13354 amod wild,mice
R9916 T13353 T13354 compound type,mice
R9917 T13354 T13351 pobj mice,to
R9918 T13355 T13319 punct .,resulted
R9919 T13356 T13358 nsubjpass This,associated
R9920 T13357 T13358 auxpass was,associated
R9921 T13358 T13358 ROOT associated,associated
R9922 T13359 T13358 prep with,associated
R9923 T13360 T13362 det a,enhancement
R9924 T13361 T13362 amod selective,enhancement
R9925 T13362 T13359 pobj enhancement,with
R9926 T13363 T13362 prep of,enhancement
R9927 T13364 T13365 compound neutrophil,recruitment
R9928 T13365 T13363 pobj recruitment,of
R9929 T13366 T13362 prep to,enhancement
R9930 T13367 T13369 det the,compartment
R9931 T13368 T13369 compound bronchoalveolar,compartment
R9932 T13369 T13366 pobj compartment,to
R9933 T13370 T13358 punct ",",associated
R9934 T13371 T13358 cc and,associated
R9935 T13372 T13358 conj resulted,associated
R9936 T13373 T13372 prep in,resulted
R9937 T13374 T13376 amod improved,clearance
R9938 T13375 T13376 amod viral,clearance
R9939 T13376 T13373 pobj clearance,in
R9940 T13377 T13378 advmod later,on
R9941 T13378 T13372 prep on,resulted
R9942 T13379 T13378 prep during,on
R9943 T13380 T13379 pobj infection,during
R9944 T13381 T13358 punct .,associated
R9945 T13382 T13390 mark Although,is
R9946 T13383 T13384 det the,role
R9947 T13384 T13390 nsubj role,is
R9948 T13385 T13384 prep of,role
R9949 T13386 T13385 pobj neutrophils,of
R9950 T13387 T13384 prep during,role
R9951 T13388 T13389 amod viral,infection
R9952 T13389 T13387 pobj infection,during
R9953 T13390 T13397 advcl is,supports
R9954 T13391 T13390 advmod still,is
R9955 T13392 T13390 prep under,is
R9956 T13393 T13392 pobj debate,under
R9957 T13394 T13397 punct ",",supports
R9958 T13395 T13396 amod recent,evidence
R9959 T13396 T13397 nsubj evidence,supports
R9960 T13397 T13397 ROOT supports,supports
R9961 T13398 T13400 det a,function
R9962 T13399 T13400 amod protective,function
R9963 T13400 T13397 dobj function,supports
R9964 T13401 T13400 prep of,function
R9965 T13402 T13403 det these,cells
R9966 T13403 T13401 pobj cells,of
R9967 T13404 T13400 prep during,function
R9968 T13405 T13406 compound IAV,infection
R9969 T13406 T13404 pobj infection,during
R9970 T13407 T13409 nmod [,]
R9971 T13408 T13409 nummod 71,]
R9972 T13409 T13400 appos ],function
R9973 T13410 T13409 punct ",",]
R9974 T13411 T13409 conj [,]
R9975 T13412 T13413 nummod 72,]
R9976 T13413 T13409 appos ],]
R9983 T13420 T13419 agent by,affected
R9984 T13421 T13422 det the,absence
R9985 T13422 T13420 pobj absence,by
R9986 T13423 T13422 prep of,absence
R9987 T13424 T13423 pobj A20,of
R9988 T13425 T13422 prep in,absence
R9989 T13426 T13427 amod myeloid,cells
R9990 T13427 T13425 pobj cells,in
R9991 T13428 T13422 punct ",",absence
R9992 T13429 T13430 nsubj which,is
R9993 T13430 T13422 relcl is,absence
R9994 T13431 T13430 acomp consistent,is
R9995 T13432 T13431 prep with,consistent
R9996 T13433 T13434 det the,notion
R9997 T13434 T13432 pobj notion,with
R9998 T13435 T13439 mark that,are
R9999 T13436 T13438 amod airway,cells
R10000 T13437 T13438 amod epithelial,cells
R10001 T13438 T13439 nsubj cells,are
R10002 T13439 T13434 acl are,notion
R10003 T13440 T13442 det the,source
R10004 T13441 T13442 amod primary,source
R10005 T13442 T13439 attr source,are
R10006 T13443 T13442 prep of,source
R10007 T13444 T13445 amod MCP-1,production
R10008 T13445 T13443 pobj production,of
R10009 T13446 T13442 prep during,source
R10010 T13447 T13448 compound IAV,infection
R10011 T13448 T13446 pobj infection,during
R10012 T13449 T13451 nmod [,]
R10013 T13450 T13451 nummod 73,]
R10014 T13451 T13448 npadvmod ],infection
R10015 T13452 T13419 punct .,affected
R10016 T13453 T13454 compound Mice,deficient
R10017 T13454 T13472 nsubjpass deficient,protected
R10018 T13455 T13454 prep for,deficient
R10019 T13456 T13459 det the,CCR2
R10020 T13457 T13458 compound MCP-1,receptor
R10021 T13458 T13459 compound receptor,CCR2
R10022 T13459 T13455 pobj CCR2,for
R10023 T13460 T13459 punct ",",CCR2
R10024 T13461 T13463 nsubjpass which,expressed
R10025 T13462 T13463 auxpass is,expressed
R10026 T13463 T13459 relcl expressed,CCR2
R10027 T13464 T13463 prep on,expressed
R10028 T13465 T13466 det a,subset
R10029 T13466 T13464 pobj subset,on
R10030 T13467 T13466 prep of,subset
R10031 T13468 T13469 amod circulating,monocytes
R10032 T13469 T13467 pobj monocytes,of
R10033 T13470 T13472 punct ",",protected
R10034 T13471 T13472 auxpass are,protected
R10035 T13472 T13472 ROOT protected,protected
R10036 T13473 T13472 prep against,protected
R10037 T13474 T13475 compound IAV,infection
R10038 T13475 T13473 pobj infection,against
R10039 T13476 T13475 cc and,infection
R10040 T13477 T13475 conj display,infection
R10041 T13478 T13472 conj reduced,protected
R10042 T13479 T13478 dobj signs,reduced
R10043 T13480 T13479 prep of,signs
R10044 T13481 T13482 compound immunopathology,[
R10045 T13482 T13484 nmod [,]
R10046 T13483 T13484 nummod 74,]
R10047 T13484 T13480 pobj ],of
R10048 T13485 T13487 nmod [,]
R10049 T13486 T13487 nummod 76,]
R10050 T13487 T13479 conj ],signs
R10051 T13488 T13472 punct .,protected
R10052 T13489 T13494 prep During,develop
R10053 T13490 T13491 compound IAV,infection
R10054 T13491 T13489 pobj infection,During
R10055 T13492 T13493 det these,monocytes
R10056 T13493 T13494 nsubj monocytes,develop
R10057 T13494 T13494 ROOT develop,develop
R10058 T13495 T13494 prep into,develop
R10059 T13496 T13498 amod inflammatory,cells
R10060 T13497 T13498 amod dendritic,cells
R10061 T13498 T13495 pobj cells,into
R10062 T13499 T13498 cc or,cells
R10064 T13501 T13498 conj macrophages,cells
R10065 T13502 T13504 nmod [,]
R10066 T13503 T13504 nummod 77,]
R10067 T13504 T13494 dobj ],develop
R10068 T13505 T13494 cc and,develop
R10069 T13506 T13507 auxpass are,considered
R10070 T13507 T13494 conj considered,develop
R10071 T13508 T13509 amod major,contributors
R10072 T13509 T13507 oprd contributors,considered
R10073 T13510 T13511 aux to,IAV-induced
R10074 T13511 T13507 xcomp IAV-induced,considered
R10075 T13512 T13513 compound immunopathology,[
R10076 T13513 T13511 dobj [,IAV-induced
R10077 T13514 T13515 nummod 78,]
R10078 T13515 T13513 appos ],[
R10079 T13516 T13494 punct .,develop
R10080 T13517 T13518 amod A20myel-KO,mice
R10081 T13518 T13520 nsubjpass mice,protected
R10082 T13519 T13520 auxpass were,protected
R10083 T13520 T13520 ROOT protected,protected
R10084 T13521 T13520 prep against,protected
R10085 T13522 T13525 det a,infection
R10086 T13523 T13525 amod lethal,infection
R10087 T13524 T13525 compound IAV,infection
R10088 T13525 T13521 pobj infection,against
R10089 T13526 T13525 punct ",",infection
R10090 T13527 T13528 nsubj which,is
R10091 T13528 T13525 relcl is,infection
R10092 T13529 T13530 advmod rather,surprising
R10093 T13530 T13528 acomp surprising,is
R10094 T13531 T13546 mark since,believed
R10095 T13532 T13536 det an,response
R10096 T13533 T13536 amod excessive,response
R10097 T13534 T13536 amod proinflammatory,response
R10098 T13535 T13536 compound cytokine,response
R10099 T13536 T13546 nsubjpass response,believed
R10100 T13537 T13536 cc and,response
R10101 T13538 T13540 det an,influx
R10102 T13539 T13540 amod excessive,influx
R10103 T13540 T13536 conj influx,response
R10104 T13541 T13540 prep of,influx
R10105 T13542 T13543 amod inflammatory,cells
R10106 T13543 T13541 pobj cells,of
R10107 T13544 T13546 auxpass is,believed
R10108 T13545 T13546 advmod generally,believed
R10109 T13546 T13528 advcl believed,is
R10110 T13547 T13549 aux to,associated
R10111 T13548 T13549 auxpass be,associated
R10112 T13549 T13546 xcomp associated,believed
R10113 T13550 T13549 prep with,associated
R10114 T13551 T13552 amod increased,lethality
R10115 T13552 T13553 compound lethality,[
R10116 T13553 T13550 pobj [,with
R10117 T13554 T13555 nummod 64,]
R10118 T13555 T13553 conj ],[
R10119 T13556 T13555 punct ",",]
R10120 T13557 T13555 conj [,]
R10121 T13558 T13559 nummod 79,]
R10122 T13559 T13555 conj ],]
R10123 T13560 T13520 punct .,protected
R10124 T13561 T13594 advmod However,are
R10125 T13562 T13594 punct ",",are
R10126 T13563 T13565 det the,effect
R10127 T13564 T13565 amod selective,effect
R10128 T13565 T13594 nsubj effect,are
R10129 T13566 T13565 prep of,effect
R10130 T13567 T13568 compound A20,deficiency
R10131 T13568 T13566 pobj deficiency,of
R10132 T13569 T13568 prep on,deficiency
R10133 T13570 T13571 compound neutrophil,recruitment
R10134 T13571 T13569 pobj recruitment,on
R10135 T13572 T13565 punct ",",effect
R10136 T13573 T13565 prep without,effect
R10137 T13574 T13573 pcomp altering,without
R10138 T13575 T13576 amod inflammatory,monocyte
R10139 T13576 T13574 dobj monocyte,altering
R10140 T13577 T13576 punct (,monocyte
R10141 T13578 T13579 compound Ly6C,+
R10142 T13579 T13581 npadvmod +,+
R10143 T13580 T13581 compound CD11b,+
R10144 T13581 T13574 advmod +,altering
R10145 T13582 T13581 punct ),+
R10146 T13583 T13594 nsubj recruitment,are
R10147 T13584 T13583 punct ",",recruitment
R10148 T13585 T13586 amod further,support
R10149 T13586 T13583 appos support,recruitment
R10150 T13587 T13588 det the,idea
R10151 T13588 T13583 conj idea,recruitment
R10152 T13589 T13590 nsubj that,monocytes
R10153 T13590 T13588 relcl monocytes,idea
R10154 T13591 T13590 cc and,monocytes
R10155 T13592 T13593 neg not,neutrophils
R10156 T13593 T13594 nsubj neutrophils,are
R10157 T13594 T13594 ROOT are,are
R10158 T13595 T13596 amod major,contributors
R10159 T13596 T13594 attr contributors,are
R10160 T13597 T13599 aux to,immunopathology
R10161 T13598 T13599 advmod IAV-associated,immunopathology
R10162 T13599 T13594 advcl immunopathology,are
R10163 T13600 T13599 cc and,immunopathology
R10164 T13601 T13602 compound lethality,[
R10165 T13602 T13599 conj [,immunopathology
R10166 T13603 T13604 nummod 78,]
R10167 T13604 T13602 appos ],[
R10168 T13605 T13594 punct .,are
R10169 T13606 T13607 nsubj We,show
R10170 T13607 T13607 ROOT show,show
R10171 T13608 T13613 mark that,enhanced
R10172 T13609 T13612 nummod A20,display
R10173 T13610 T13612 amod deficient,display
R10174 T13611 T13612 compound BMDM,display
R10175 T13612 T13613 nsubj display,enhanced
R10176 T13613 T13607 ccomp enhanced,show
R10177 T13614 T13613 dobj NF-κB,enhanced
R10178 T13615 T13614 cc and,NF-κB
R10179 T13616 T13614 conj IRF3,NF-κB
R10180 T13617 T13627 nsubj activation,stranded
R10181 T13618 T13617 prep in,activation
R10182 T13619 T13618 pobj response,in
R10183 T13620 T13619 prep to,response
R10184 T13621 T13622 compound RIG-I,stimulation
R10185 T13622 T13620 pobj stimulation,to
R10186 T13623 T13622 prep by,stimulation
R10187 T13624 T13626 amod synthetic,double
R10188 T13625 T13626 compound LMW,double
R10189 T13626 T13623 pobj double,by
R10190 T13627 T13613 conj stranded,enhanced
R10191 T13628 T13627 dobj RNA,stranded
R10192 T13629 T13607 punct .,show
R10193 T13630 T13634 nsubj RIG-I,shown
R10194 T13631 T13634 aux has,shown
R10195 T13632 T13634 advmod previously,shown
R10196 T13633 T13634 auxpass been,shown
R10197 T13634 T13634 ROOT shown,shown
R10198 T13635 T13636 aux to,play
R10199 T13636 T13634 xcomp play,shown
R10200 T13637 T13639 det a,role
R10201 T13638 T13639 amod key,role
R10202 T13639 T13636 dobj role,play
R10203 T13640 T13636 prep in,play
R10204 T13641 T13644 det the,response
R10205 T13642 T13644 amod innate,response
R10206 T13643 T13644 amod immune,response
R10207 T13644 T13640 pobj response,in
R10208 T13645 T13644 prep to,response
R10209 T13646 T13647 compound IAV,[
R10210 T13647 T13645 pobj [,to
R10211 T13648 T13649 nummod 13,]
R10212 T13649 T13649 ROOT ],]
R10213 T13650 T13634 punct ",",shown
R10214 T13651 T13634 advcl suggesting,shown
R10215 T13652 T13664 mark that,reflects
R10216 T13653 T13656 det the,response
R10217 T13654 T13656 amod increased,response
R10219 T13656 T13664 nsubj response,reflects
R10220 T13657 T13656 prep of,response
R10221 T13658 T13659 amod A20myel-KO,mice
R10222 T13659 T13657 pobj mice,of
R10223 T13660 T13656 prep to,response
R10224 T13661 T13663 compound IAV,infection
R10225 T13662 T13663 compound lung,infection
R10226 T13663 T13660 pobj infection,to
R10227 T13664 T13651 ccomp reflects,suggesting
R10228 T13665 T13667 amod enhanced,signaling
R10229 T13666 T13667 compound RIG-I,signaling
R10230 T13667 T13664 dobj signaling,reflects
R10231 T13668 T13634 punct .,shown
R10232 T13669 T13670 nsubj We,propose
R10233 T13670 T13670 ROOT propose,propose
R10234 T13671 T13673 mark that,inhibits
R10235 T13672 T13673 nummod A20,inhibits
R10236 T13673 T13670 ccomp inhibits,propose
R10237 T13674 T13677 nmod IAV-induced,expression
R10238 T13675 T13677 amod proinflammatory,expression
R10239 T13676 T13677 compound gene,expression
R10240 T13677 T13673 dobj expression,inhibits
R10241 T13678 T13680 punct (,shown
R10242 T13679 T13680 mark as,shown
R10243 T13680 T13677 advcl shown,expression
R10244 T13681 T13680 prep in,shown
R10245 T13682 T13683 poss our,manuscript
R10246 T13683 T13681 pobj manuscript,in
R10247 T13684 T13683 prep for,manuscript
R10248 T13685 T13684 pobj TNF,for
R10249 T13686 T13685 punct ",",TNF
R10250 T13687 T13685 conj IL-6,TNF
R10251 T13688 T13687 punct ",",IL-6
R10252 T13689 T13687 conj KC,IL-6
R10253 T13690 T13689 punct ",",KC
R10254 T13691 T13689 conj MIP-2,KC
R10255 T13692 T13691 punct ",",MIP-2
R10256 T13693 T13691 cc and,MIP-2
R10257 T13694 T13691 conj IFNβ,MIP-2
R10258 T13695 T13680 punct ),shown
R10259 T13696 T13673 prep by,inhibits
R10260 T13697 T13698 advmod negatively,regulating
R10261 T13698 T13696 pcomp regulating,by
R10262 T13699 T13698 dobj NF-κB,regulating
R10263 T13700 T13699 cc and,NF-κB
R10264 T13701 T13702 compound IRF3,activation
R10265 T13702 T13699 conj activation,NF-κB
R10266 T13703 T13698 punct ",",regulating
R10267 T13704 T13705 nsubj which,are
R10268 T13705 T13673 relcl are,inhibits
R10269 T13706 T13708 det the,pathways
R10270 T13707 T13708 amod major,pathways
R10271 T13708 T13705 attr pathways,are
R10272 T13709 T13708 acl controlling,pathways
R10273 T13710 T13711 det these,genes
R10274 T13711 T13709 dobj genes,controlling
R10275 T13712 T13670 punct .,propose
R10276 T13713 T13718 advmod However,exclude
R10277 T13714 T13718 punct ",",exclude
R10278 T13715 T13718 nsubj this,exclude
R10279 T13716 T13718 aux does,exclude
R10280 T13717 T13718 neg not,exclude
R10281 T13718 T13718 ROOT exclude,exclude
R10282 T13719 T13721 det an,effect
R10283 T13720 T13721 amod additional,effect
R10284 T13721 T13718 dobj effect,exclude
R10285 T13722 T13721 prep of,effect
R10286 T13723 T13722 pobj A20,of
R10287 T13724 T13721 prep on,effect
R10288 T13725 T13727 amod other,pathways
R10289 T13726 T13727 amod signaling,pathways
R10290 T13727 T13724 pobj pathways,on
R10291 T13728 T13730 nsubj that,contribute
R10296 T13733 T13734 compound gene,expression
R10297 T13734 T13731 pobj expression,to
R10298 T13735 T13718 punct .,exclude
R10299 T13736 T13738 nsubjpass A20,believed
R10300 T13737 T13738 auxpass is,believed
R10301 T13738 T13738 ROOT believed,believed
R10302 T13739 T13740 aux to,exert
R10303 T13740 T13738 xcomp exert,believed
R10304 T13741 T13746 poss its,functions
R10305 T13742 T13746 nmod NF-κB,functions
R10306 T13743 T13742 cc and,NF-κB
R10307 T13744 T13742 conj IRF3,NF-κB
R10308 T13745 T13746 amod inhibitory,functions
R10309 T13746 T13740 dobj functions,exert
R10310 T13747 T13740 prep by,exert
R10311 T13748 T13747 pcomp modulating,by
R10312 T13749 T13751 det the,status
R10313 T13750 T13751 amod ubiquitination,status
R10314 T13751 T13748 dobj status,modulating
R10315 T13752 T13751 prep of,status
R10316 T13753 T13755 amod different,proteins
R10317 T13754 T13755 compound signaling,proteins
R10318 T13755 T13752 pobj proteins,of
R10319 T13756 T13758 nmod [,]
R10320 T13757 T13758 nummod 80,]
R10321 T13758 T13751 appos ],status
R10322 T13759 T13738 punct .,believed
R10323 T13760 T13767 prep In,shown
R10324 T13761 T13762 det this,context
R10325 T13762 T13760 pobj context,In
R10326 T13763 T13767 punct ",",shown
R10327 T13764 T13767 nsubjpass it,shown
R10328 T13765 T13767 auxpass was,shown
R10329 T13766 T13767 advmod recently,shown
R10330 T13767 T13767 ROOT shown,shown
R10331 T13768 T13767 dobj that,shown
R10332 T13769 T13770 nummod A20,cooperates
R10333 T13770 T13768 advmod cooperates,that
R10334 T13771 T13770 prep with,cooperates
R10335 T13772 T13774 det the,proteins
R10336 T13773 T13774 amod ubiquitin-binding,proteins
R10337 T13774 T13771 pobj proteins,with
R10338 T13775 T13774 appos TAX1BP1,proteins
R10339 T13776 T13775 cc and,TAX1BP1
R10340 T13777 T13775 conj ABIN1,TAX1BP1
R10341 T13778 T13780 aux to,disrupt
R10342 T13779 T13780 aux to,disrupt
R10343 T13780 T13770 xcomp disrupt,cooperates
R10344 T13781 T13783 det the,complex
R10345 T13782 T13783 compound TRAF3-TBK1-IKKε,complex
R10346 T13783 T13780 dobj complex,disrupt
R10347 T13784 T13770 punct ",",cooperates
R10348 T13785 T13787 advmod thereby,affecting
R10349 T13786 T13787 advmod negatively,affecting
R10350 T13787 T13770 conj affecting,cooperates
R10351 T13788 T13787 dobj K63-polyubiquitination,affecting
R10352 T13789 T13788 prep of,K63-polyubiquitination
R10353 T13790 T13789 pobj TBK1,of
R10354 T13791 T13790 cc and,TBK1
R10355 T13792 T13790 conj IKKε,TBK1
R10356 T13793 T13792 punct ",",IKKε
R10357 T13794 T13792 cc and,IKKε
R10358 T13795 T13796 poss their,ability
R10359 T13796 T13787 dobj ability,affecting
R10360 T13797 T13798 aux to,activity
R10361 T13798 T13787 advcl activity,affecting
R10362 T13799 T13802 nummod IRF3,]
R10363 T13800 T13802 nmod [,]
R10364 T13801 T13802 nummod 81,]
R10365 T13802 T13798 dobj ],activity
R10366 T13803 T13802 punct ",",]
R10367 T13804 T13802 conj [,]
R10368 T13805 T13806 nummod 82,]
R10369 T13806 T13802 conj ],]
R10370 T13807 T13767 punct .,shown
R10371 T13808 T13812 mark Whether,involved
R10372 T13809 T13810 amod similar,mechanisms
R10373 T13810 T13812 nsubjpass mechanisms,involved
R10374 T13811 T13812 auxpass are,involved
R10375 T13812 T13821 advcl involved,is
R10376 T13813 T13812 prep in,involved
R10377 T13814 T13815 det the,regulation
R10378 T13815 T13813 pobj regulation,in
R10379 T13816 T13815 prep of,regulation
R10380 T13817 T13816 pobj RIG-I,of
R10381 T13818 T13820 amod induced,activation
R10382 T13819 T13820 compound NF-κB,activation
R10383 T13820 T13821 nsubj activation,is
R10384 T13821 T13821 ROOT is,is
R10385 T13822 T13821 advmod still,is
R10386 T13823 T13821 acomp unclear,is
R10387 T13824 T13821 punct .,is
R10388 T13825 T13826 advmod So,far
R10389 T13826 T13828 advmod far,were
R10390 T13827 T13828 nsubj we,were
R10391 T13828 T13828 ROOT were,were
R10392 T13829 T13828 acomp unable,were
R10393 T13830 T13832 aux to,detect
R10394 T13831 T13832 advmod clearly,detect
R10395 T13832 T13829 xcomp detect,unable
R10396 T13833 T13832 dobj ubiquitination,detect
R10397 T13834 T13833 prep of,ubiquitination
R10398 T13835 T13834 pobj TBK1,of
R10399 T13836 T13835 cc and,TBK1
R10400 T13837 T13833 conj IKKε,ubiquitination
R10401 T13838 T13837 prep in,IKKε
R10402 T13839 T13840 amod primary,macrophages
R10403 T13840 T13838 pobj macrophages,in
R10404 T13841 T13828 punct ",",were
R10405 T13842 T13828 advcl preventing,were
R10406 T13843 T13842 dobj us,preventing
R10407 T13844 T13842 prep from,preventing
R10408 T13845 T13844 pcomp studying,from
R10409 T13846 T13847 det the,effect
R10410 T13847 T13845 dobj effect,studying
R10411 T13848 T13847 prep of,effect
R10412 T13849 T13850 compound A20,deficiency
R10413 T13850 T13848 pobj deficiency,of
R10414 T13851 T13845 prep on,studying
R10415 T13852 T13854 poss their,status
R10416 T13853 T13854 compound ubiquitination,status
R10417 T13951 T13952 advmod so,far
R10418 T13952 T13954 advmod far,limited
R10419 T13953 T13954 auxpass was,limited
R10420 T13954 T13954 ROOT limited,limited
R10421 T13955 T13954 prep to,limited
R10422 T13956 T13954 prep in,limited
R10423 T13957 T13958 amod vitro,data
R10424 T13958 T13956 pobj data,in
R10425 T13959 T13954 cc and,limited
R10426 T13960 T13961 auxpass was,obtained
R10427 T13961 T13954 conj obtained,limited
R10428 T13962 T13961 prep under,obtained
R10429 T13963 T13964 amod non-physiological,conditions
R10430 T13964 T13962 pobj conditions,under
R10431 T13854 T13851 pobj status,on
R10432 T13965 T13954 punct .,limited
R10433 T13855 T13828 punct .,were
R10434 T13856 T13860 nsubjpass It,excluded
R10435 T13857 T13860 aux can,excluded
R10436 T13966 T13969 det The,phenotype
R10437 T13858 T13860 neg not,excluded
R10438 T13859 T13860 auxpass be,excluded
R10439 T13967 T13969 amod clear,phenotype
R10440 T13860 T13860 ROOT excluded,excluded
R10441 T13861 T13860 advmod however,excluded
R10442 T13862 T13865 mark that,targets
R10443 T13968 T13969 amod protective,phenotype
R10444 T13863 T13865 nsubj A20,targets
R10445 T13864 T13865 advmod also,targets
R10446 T13969 T13977 nsubj phenotype,indicates
R10447 T13865 T13860 ccomp targets,excluded
R10448 T13866 T13867 amod other,substrates
R10449 T13867 T13865 dobj substrates,targets
R10450 T13970 T13969 prep of,phenotype
R10451 T13868 T13869 nsubj that,mediate
R10452 T13869 T13867 relcl mediate,substrates
R10453 T13971 T13972 amod A20myel-KO,mice
R10454 T13870 T13869 dobj NF-κB,mediate
R10455 T13871 T13870 cc and,NF-κB
R10456 T13872 T13870 conj IRF3,NF-κB
R10457 T13873 T13869 dobj activation,mediate
R10458 T13972 T13970 pobj mice,of
R10459 T13874 T13873 prep in,activation
R10460 T13875 T13876 amod myeloid,cells
R10461 T13876 T13874 pobj cells,in
R10462 T13973 T13976 dobj that,describe
R10463 T13877 T13860 punct .,excluded
R10464 T13878 T13879 det The,identification
R10465 T13879 T13884 nsubj identification,be
R10466 T13974 T13976 nsubj we,describe
R10467 T13880 T13879 prep of,identification
R10468 T13881 T13882 det these,substrates
R10469 T13975 T13976 advmod here,describe
R10470 T13882 T13880 pobj substrates,of
R10471 T13883 T13884 aux will,be
R10472 T13884 T13884 ROOT be,be
R10473 T13885 T13886 det the,topic
R10474 T13976 T13972 relcl describe,mice
R10475 T13886 T13884 attr topic,be
R10476 T13977 T13977 ROOT indicates,indicates
R10477 T13978 T13984 mark that,is
R10480 T13979 T13980 compound A20,expression
R10486 T13980 T13984 nsubj expression,is
R10487 T13981 T13980 prep in,expression
R10488 T13894 T13897 amod Multiple,enzymes
R10489 T13895 T13897 amod other,enzymes
R10490 T13982 T13983 amod myeloid,cells
R10491 T13896 T13897 amod deubiquitinating,enzymes
R10492 T13897 T13933 nsubjpass enzymes,shown
R10493 T13898 T13899 punct (,DUBs
R10494 T13983 T13981 pobj cells,in
R10495 T13899 T13897 appos DUBs,enzymes
R10496 T13900 T13897 punct ),enzymes
R10497 T13901 T13897 punct ",",enzymes
R10498 T13984 T13977 ccomp is,indicates
R10499 T13902 T13903 amod such,as
R10500 T13903 T13897 prep as,enzymes
R10501 T13985 T13987 det a,gatekeeper
R10502 T13904 T13905 compound DUBA,[
R10503 T13905 T13903 pobj [,as
R10504 T13986 T13987 amod central,gatekeeper
R10505 T13906 T13907 compound 28,]
R10506 T13907 T13905 conj ],[
R10507 T13908 T13907 punct ",",]
R10508 T13987 T13984 attr gatekeeper,is
R10509 T13909 T13910 compound CYLD,[
R10510 T13910 T13907 conj [,]
R10511 T13911 T13912 compound 29,]
R10512 T13912 T13907 conj ],]
R10513 T13988 T13987 prep of,gatekeeper
R10514 T13913 T13912 punct ",",]
R10515 T13914 T13912 conj [,]
R10516 T13915 T13916 nummod 30,]
R10517 T13989 T13988 pobj RIG-I,of
R10518 T13916 T13912 conj ],]
R10519 T13917 T13916 punct ",",]
R10520 T13918 T13919 compound OTUB1/2,[
R10521 T13990 T13987 acl induced,gatekeeper
R10522 T13919 T13916 conj [,]
R10523 T13920 T13921 nummod 31,]
R10524 T13991 T13990 xcomp signaling,induced
R10525 T13921 T13928 nmod ],[
R10526 T13922 T13921 punct ",",]
R10527 T13923 T13921 cc and,]
R10528 T13992 T13991 prep in,signaling
R10529 T13924 T13925 compound A20,[
R10530 T13925 T13921 conj [,]
R10531 T13993 T13992 pobj response,in
R10532 T13926 T13927 nummod 49,]
R10533 T13927 T13928 nmod ],[
R10534 T13928 T13930 det [,]
R10535 T13929 T13930 nummod 52,]
R10536 T13930 T13916 conj ],]
R10537 T13931 T13933 aux have,shown
R10538 T13994 T13993 prep to,response
R10539 T13932 T13933 auxpass been,shown
R10540 T13933 T13933 ROOT shown,shown
R10541 T13934 T13936 aux to,regulate
R10542 T13995 T13996 compound IAV,infection
R10543 T13935 T13936 advmod negatively,regulate
R10544 T13936 T13933 xcomp regulate,shown
R10545 T13937 T13938 nsubj RIG-I,signaling
R10546 T13996 T13994 pobj infection,to
R10547 T13938 T13936 ccomp signaling,regulate
R10548 T13939 T13938 prep to,signaling
R10549 T13940 T13939 pobj NF-κB,to
R10550 T13997 T13990 cc and,induced
R10551 T13941 T13940 cc and,NF-κB
R10552 T13942 T13940 conj IRF-3,NF-κB
R10553 T13943 T13938 punct ",",signaling
R10554 T13998 T14003 mark that,substitute
R10555 T13944 T13933 advcl implicating,shown
R10556 T13945 T13946 amod possible,redundancy
R10557 T13999 T14000 amod other,DUBs
R10558 T13946 T13944 dobj redundancy,implicating
R10559 T13947 T13933 punct .,shown
R10560 T13948 T13954 advmod However,limited
R10561 T14000 T14003 nsubj DUBs,substitute
R10562 T13949 T13954 punct ",",limited
R10563 T13950 T13954 nsubjpass evidence,limited
R10564 T14001 T14003 aux can,substitute
R10565 T14002 T14003 neg not,substitute
R10566 T14003 T13990 conj substitute,induced
R10567 T14004 T14003 prep for,substitute
R10568 T14005 T14006 compound A20,deficiency
R10569 T14048 T14051 amod innate,responses
R10570 T14049 T14051 amod antiviral,responses
R10571 T14006 T14004 pobj deficiency,for
R10572 T14050 T14051 amod immune,responses
R10573 T14007 T14003 prep under,substitute
R10574 T14008 T14009 amod physiological,conditions
R10577 T14009 T14007 pobj conditions,under
R10580 T14010 T13977 punct .,indicates
R10584 T14058 T14056 pobj therapies,toward
R10585 T14059 T14052 punct .,is
R10586 T14011 T14013 mark If,has
R10587 T14060 T14062 advmod About,fifth
R10588 T14061 T14062 det a,fifth
R10589 T14062 T14068 nsubjpass fifth,infected
R10590 T14012 T14013 nsubj A20,has
R10591 T14063 T14062 prep of,fifth
R10592 T14064 T14066 poss world,population
R10593 T14013 T14037 advcl has,remains
R10594 T14065 T14064 case 's,world
R10595 T14066 T14063 pobj population,of
R10596 T14067 T14068 auxpass is,infected
R10597 T14068 T14068 ROOT infected,infected
R10598 T14014 T14017 det a,role
R10599 T14069 T14068 agent by,infected
R10600 T14070 T14069 pobj IAV,by
R10601 T14015 T14017 amod similar,role
R10602 T14071 T14068 advmod annually,infected
R10603 T14072 T14068 punct ",",infected
R10604 T14073 T14068 advcl leading,infected
R10605 T14016 T14017 amod non-redundant,role
R10606 T14017 T14013 dobj role,has
R10607 T14018 T14017 prep in,role
R10608 T14074 T14073 prep to,leading
R10609 T14019 T14021 amod other,types
R10610 T14075 T14076 amod high,morbidity
R10611 T14020 T14021 compound cell,types
R10612 T14076 T14074 pobj morbidity,to
R10613 T14077 T14076 cc and,morbidity
R10614 T14078 T14076 conj mortality,morbidity
R10615 T14021 T14018 pobj types,in
R10616 T14079 T14068 punct ",",infected
R10617 T14080 T14081 advmod particularly,in
R10618 T14081 T14068 prep in,infected
R10619 T14022 T14024 nsubjpass that,implicated
R10620 T14082 T14081 pobj infants,in
R10621 T14083 T14068 punct ",",infected
R10622 T14084 T14085 det the,elderly
R10623 T14023 T14024 auxpass are,implicated
R10624 T14085 T14068 conj elderly,infected
R10625 T14086 T14085 cc and,elderly
R10626 T14087 T14088 det the,immunocompromised
R10627 T14024 T14021 relcl implicated,types
R10628 T14088 T14085 conj immunocompromised,elderly
R10629 T14089 T14068 punct .,infected
R10630 T14090 T14093 det The,rate
R10631 T14025 T14024 prep in,implicated
R10632 T14091 T14093 amod high,rate
R10633 T14092 T14093 compound mutation,rate
R10634 T14093 T14096 nsubj rate,turns
R10635 T14094 T14093 prep of,rate
R10636 T14095 T14094 pobj IAV,of
R10637 T14026 T14027 det the,response
R10638 T14096 T14096 ROOT turns,turns
R10639 T14097 T14098 det all,attempts
R10640 T14098 T14096 dobj attempts,turns
R10641 T14027 T14025 pobj response,in
R10642 T14099 T14098 prep of,attempts
R10643 T14100 T14099 pobj vaccine,of
R10644 T14101 T14100 cc and,vaccine
R10645 T14028 T14027 prep to,response
R10646 T14102 T14103 amod antiviral,design
R10647 T14103 T14100 conj design,vaccine
R10648 T14104 T14096 prep into,turns
R10649 T14029 T14028 pobj IAV,to
R10650 T14105 T14108 det a,battle
R10651 T14106 T14107 neg never,ending
R10652 T14107 T14108 amod ending,battle
R10653 T14030 T14027 punct ",",response
R10654 T14108 T14104 pobj battle,into
R10655 T14109 T14096 punct .,turns
R10656 T14110 T14129 prep In,evolved
R10657 T14031 T14032 amod such,as
R10658 T14111 T14112 amod recent,years
R10659 T14112 T14110 pobj years,In
R10660 T14113 T14129 punct ",",evolved
R10661 T14114 T14115 compound RNA,interference
R10662 T14032 T14027 prep as,response
R10663 T14115 T14129 nsubj interference,evolved
R10664 T14116 T14117 punct ",",triggered
R10665 T14117 T14115 acl triggered,interference
R10666 T14033 T14035 nmod lung,cells
R10667 T14118 T14117 agent by,triggered
R10668 T14119 T14122 amod synthetic,RNA
R10669 T14120 T14121 amod short,interfering
R10670 T14034 T14035 amod epithelial,cells
R10671 T14121 T14122 amod interfering,RNA
R10672 T14122 T14118 pobj RNA,by
R10673 T14035 T14032 pobj cells,as
R10674 T14036 T14037 punct ",",remains
R10677 T14037 T14037 ROOT remains,remains
R10681 T14038 T14040 aux to,investigated
R10683 T14039 T14040 auxpass be,investigated
R10688 T14040 T14037 xcomp investigated,remains
R10691 T14135 T14129 punct .,evolved
R10692 T14136 T14137 advmod Properly,designed
R10693 T14041 T14037 punct .,remains
R10694 T14137 T14138 amod designed,siRNAs
R10695 T14138 T14141 nsubjpass siRNAs,shown
R10696 T14042 T14052 nsubj Understanding,is
R10697 T14139 T14141 aux have,shown
R10698 T14140 T14141 auxpass been,shown
R10699 T14141 T14141 ROOT shown,shown
R10700 T14043 T14042 cc and,Understanding
R10701 T14142 T14143 aux to,function
R10702 T14143 T14141 xcomp function,shown
R10703 T14144 T14143 prep as,function
R10704 T14044 T14042 conj controlling,Understanding
R10705 T14045 T14046 det the,activation
R10706 T14046 T14044 dobj activation,controlling
R10707 T14047 T14046 prep of,activation
R10708 T14145 T14146 amod potent,inhibitors
R10709 T14146 T14144 pobj inhibitors,as
R10710 T14147 T14146 prep of,inhibitors
R10711 T14242 T14241 prep of,targeting
R10712 T14148 T14149 compound influenza,virus
R10713 T14243 T14242 pobj A20,of
R10714 T14149 T14150 compound virus,replication
R10715 T14150 T14147 pobj replication,of
R10716 T14151 T14141 punct .,shown
R10717 T14244 T14245 aux might,be
R10718 T14152 T14157 mark Although,remain
R10719 T14153 T14157 nsubj specificity,remain
R10720 T14154 T14153 cc and,specificity
R10721 T14245 T14245 ROOT be,be
R10722 T14155 T14156 compound tissue,delivery
R10723 T14156 T14153 conj delivery,specificity
R10724 T14157 T14186 advcl remain,experienced
R10725 T14246 T14245 prep of,be
R10726 T14158 T14159 amod major,bottlenecks
R10727 T14159 T14157 dobj bottlenecks,remain
R10728 T14160 T14157 prep in,remain
R10729 T14247 T14246 pobj interest,of
R10730 T14161 T14163 det the,applications
R10731 T14162 T14163 amod clinical,applications
R10732 T14248 T14247 prep in,interest
R10733 T14163 T14160 pobj applications,in
R10734 T14164 T14163 prep of,applications
R10735 T14165 T14164 pobj RNAi,of
R10736 T14166 T14165 prep in,RNAi
R10737 T14167 T14166 amod general,in
R10738 T14168 T14165 punct ",",RNAi
R10739 T14169 T14170 amod intranasal,application
R10740 T14249 T14250 det the,battle
R10741 T14170 T14157 npadvmod application,remain
R10742 T14171 T14170 prep of,application
R10743 T14250 T14248 pobj battle,in
R10744 T14172 T14171 pobj siRNA,of
R10745 T14251 T14250 prep against,battle
R10746 T14173 T14172 prep against,siRNA
R10747 T14174 T14175 amod respiratory,viruses
R10748 T14175 T14173 pobj viruses,against
R10749 T14176 T14175 prep including,viruses
R10750 T14252 T14254 amod other,infections
R10751 T14177 T14170 punct ",",application
R10752 T14178 T14170 cc but,application
R10753 T14179 T14180 neg not,limited
R10754 T14253 T14254 amod viral,infections
R10755 T14180 T14183 amod limited,virus
R10756 T14181 T14182 aux to,influenza
R10757 T14182 T14183 compound influenza,virus
R10758 T14254 T14251 pobj infections,against
R10759 T14183 T14170 conj virus,application
R10760 T14184 T14186 punct ",",experienced
R10761 T14185 T14186 aux has,experienced
R10762 T14255 T14254 prep including,infections
R10763 T14186 T14186 ROOT experienced,experienced
R10764 T14187 T14188 amod significant,success
R10765 T14188 T14186 dobj success,experienced
R10766 T14189 T14188 cc and,success
R10767 T14256 T14255 pobj RSV,including
R10768 T14190 T14188 conj optimism,success
R10769 T14191 T14193 nmod [,]
R10770 T14192 T14193 nummod 83,]
R10771 T14257 T14256 cc and,RSV
R10772 T14193 T14190 appos ],optimism
R10773 T14194 T14186 punct .,experienced
R10774 T14195 T14196 poss Our,results
R10775 T14258 T14259 compound SARS,coronavirus
R10776 T14196 T14197 nsubj results,suggest
R10777 T14197 T14197 ROOT suggest,suggest
R10778 T14198 T14220 mark that,be
R10779 T14259 T14256 conj coronavirus,RSV
R10780 T14199 T14220 preconj not,be
R10781 T14200 T14199 advmod only,not
R10782 T14201 T14220 nsubj siRNA,be
R10783 T14260 T14245 punct .,be
R10794 T14211 T14207 dobj response,boosting
R10795 T14212 T14211 prep by,response
R10796 T14213 T14214 amod intranasal,administration
R10797 T14214 T14212 pobj administration,by
R10798 T14215 T14214 prep of,administration
R10799 T14216 T14215 pobj siRNA,of
R10800 T14217 T14216 prep against,siRNA
R10801 T14218 T14217 pobj A20,against
R10802 T14219 T14220 aux might,be
R10803 T14220 T14197 ccomp be,suggest
R10804 T14221 T14224 det a,approach
R10805 T14222 T14224 amod valid,approach
R10806 T14223 T14224 amod therapeutic,approach
R10807 T14224 T14220 attr approach,be
R10808 T14225 T14197 punct .,suggest
R10809 T14226 T14233 advmod Also,be
R10810 T14227 T14229 amod small,inhibitors
R10811 T14228 T14229 compound compound,inhibitors
R10812 T14229 T14233 nsubj inhibitors,be
R10813 T14230 T14229 prep of,inhibitors
R10814 T14231 T14230 pobj A20,of
R10815 T14232 T14233 aux might,be
R10816 T14233 T14233 ROOT be,be
R10817 T14234 T14236 det an,alternative
R10818 T14235 T14236 amod interesting,alternative
R10819 T14236 T14233 attr alternative,be
R10820 T14237 T14233 punct .,be
R10821 T14238 T14241 advmod Finally,targeting
R10823 T14239 T14241 punct ",",targeting
R10824 T14240 T14241 amod similar,targeting
R10825 T14241 T14245 nsubj targeting,be
R11049 T14890 T14891 compound Ethics,statement
R11050 T14891 T14891 ROOT statement,statement
R11051 T14892 T14893 det All,experiments
R11052 T14893 T14897 nsubjpass experiments,conducted
R11053 T14894 T14893 prep on,experiments
R11054 T14895 T14894 pobj mice,on
R11055 T14896 T14897 auxpass were,conducted
R11056 T14897 T14891 acl conducted,statement
R11057 T14898 T14897 prep according,conducted
R11058 T14899 T14898 prep to,according
R11059 T14900 T14924 det the,regulations
R11060 T14901 T14904 amod national,Law
R11061 T14902 T14904 punct (,Law
R11062 T14903 T14904 compound Belgian,Law
R11063 T14904 T14911 nmod Law,Decree
R11064 T14905 T14904 nummod 14/08/1986,Law
R11065 T14906 T14904 cc and,Law
R11066 T14907 T14904 conj 22/12/2003,Law
R11067 T14908 T14907 punct ",",22/12/2003
R11068 T14909 T14911 compound Belgian,Decree
R11069 T14910 T14911 compound Royal,Decree
R11070 T14911 T14924 nmod Decree,regulations
R11071 T14912 T14911 nummod 06/04/2010,Decree
R11072 T14913 T14911 punct ),Decree
R11073 T14914 T14911 cc and,Decree
R11074 T14915 T14911 conj European,Decree
R11075 T14916 T14919 punct (,2010/63/EU
R11076 T14917 T14919 compound EU,2010/63/EU
R11077 T14918 T14919 compound Directives,2010/63/EU
R11078 T14919 T14911 appos 2010/63/EU,Decree
R11079 T14920 T14919 punct ",",2010/63/EU
R11080 T14921 T14919 appos 86/609/EEG,2010/63/EU
R11081 T14922 T14919 punct ),2010/63/EU
R11082 T14923 T14924 compound animal,regulations
R11083 T14924 T14899 pobj regulations,to
R11084 T14925 T14897 punct .,conducted
R11085 T14926 T14927 compound Animal,protocols
R11086 T14927 T14929 nsubjpass protocols,approved
R11087 T14928 T14929 auxpass were,approved
R11088 T14929 T14929 ROOT approved,approved
R11089 T14930 T14929 agent by,approved
R11090 T14931 T14933 det the,committee
R11091 T14932 T14933 compound ethics,committee
R11092 T14933 T14930 pobj committee,by
R11093 T14934 T14933 prep of,committee
R11094 T14935 T14936 compound Ghent,University
R11095 T14936 T14934 pobj University,of
R11096 T14937 T14938 punct (,permit
R11097 T14938 T14929 parataxis permit,approved
R11098 T14939 T14938 dobj number,permit
R11099 T14940 T14939 nummod LA1400091,number
R11100 T14941 T14940 punct ",",LA1400091
R11101 T14942 T14938 dobj approval,permit
R11102 T14943 T14942 dobj ID,approval
R11103 T14944 T14943 nummod 2010/001,ID
R11104 T14945 T14942 punct ),approval
R11105 T14946 T14938 punct .,permit
R11106 T14947 T14948 det All,efforts
R11107 T14948 T14950 nsubjpass efforts,made
R11108 T14949 T14950 auxpass were,made
R11109 T14950 T14950 ROOT made,made
R11110 T14951 T14952 aux to,ameliorate
R11111 T14952 T14950 advcl ameliorate,made
R11112 T14953 T14952 dobj suffering,ameliorate
R11113 T14954 T14953 prep of,suffering
R11114 T14955 T14954 pobj animals,of
R11115 T14956 T14950 punct .,made
R11116 T14957 T14958 nsubj Mice,were
R11117 T14958 T14958 ROOT were,were
R11118 T14959 T14958 acomp anesthetized,were
R11119 T14960 T14959 agent by,anesthetized
R11120 T14961 T14963 nmod intraperitoneal,i.p.
R11121 T14962 T14963 punct (,i.p.
R11122 T14963 T14965 amod i.p.,injection
R11123 T14964 T14963 punct ),i.p.
R11124 T14965 T14960 pobj injection,by
R11125 T14966 T14965 prep of,injection
R11126 T14967 T14968 det a,mixture
R11127 T14968 T14966 pobj mixture,of
R11128 T14969 T14968 prep of,mixture
R11129 T14970 T14969 pobj ketamine,of
R11130 T14971 T14970 punct (,ketamine
R11131 T14972 T14973 nummod 12,mg/kg
R11132 T14973 T14970 appos mg/kg,ketamine
R11133 T14974 T14970 punct ),ketamine
R11134 T14975 T14970 cc and,ketamine
R11135 T14976 T14970 conj xylazine,ketamine
R11136 T14977 T14979 punct (,mg/kg
R11137 T14978 T14979 nummod 60,mg/kg
R11138 T14979 T14976 appos mg/kg,xylazine
R11139 T14980 T14979 punct ),mg/kg
R11140 T14981 T14958 punct .,were
R11262 T15117 T15119 nmod Mice,mice
R11263 T15118 T15119 compound A20fl/fl,mice
R11264 T15119 T15121 nsubjpass mice,generated
R11265 T15120 T15121 auxpass were,generated
R11266 T15121 T15121 ROOT generated,generated
R11267 T15122 T15124 mark as,described
R11268 T15123 T15124 advmod previously,described
R11269 T15124 T15121 advcl described,generated
R11270 T15125 T15127 nmod [,]
R11271 T15126 T15127 nummod 56,]
R11272 T15127 T15124 dobj ],described
R11273 T15128 T15121 punct .,generated
R11274 T15129 T15130 amod A20fl/fl,mice
R11275 T15130 T15132 nsubjpass mice,crossed
R11276 T15131 T15132 auxpass were,crossed
R11277 T15132 T15132 ROOT crossed,crossed
R11278 T15133 T15132 prep with,crossed
R11279 T15134 T15135 compound LysM-Cre,mice
R11280 T15135 T15133 pobj mice,with
R11281 T15136 T15138 nmod [,]
R11282 T15137 T15138 nummod 84,]
R11283 T15138 T15135 appos ],mice
R11284 T15139 T15140 punct (,provided
R11285 T15140 T15138 parataxis provided,]
R11286 T15141 T15140 agent by,provided
R11287 T15142 T15143 compound I.,Förster
R11288 T15143 T15141 pobj Förster,by
R11289 T15144 T15143 punct ",",Förster
R11290 T15145 T15143 conj Institute,Förster
R11291 T15146 T15145 prep of,Institute
R11292 T15147 T15146 pobj Genetics,of
R11293 T15148 T15145 punct ",",Institute
R11294 T15149 T15145 conj University,Institute
R11295 T15150 T15149 prep of,University
R11296 T15151 T15150 pobj Cologne,of
R11297 T15152 T15151 punct ",",Cologne
R11298 T15153 T15151 appos Germany,Cologne
R11299 T15154 T15149 punct ),University
R11300 T15155 T15156 aux to,generate
R11301 T15156 T15140 xcomp generate,provided
R11302 T15157 T15159 compound A20fl/fl,transgenes
R11303 T15158 T15159 compound LysMCre,transgenes
R11304 T15159 T15156 dobj transgenes,generate
R11305 T15160 T15132 cc and,crossed
R11306 T15161 T15162 auxpass are,described
R11307 T15162 T15132 conj described,crossed
R11308 T15163 T15162 prep in,described
R11309 T15164 T15163 pobj detail,in
R11310 T15165 T15162 advmod elsewhere,described
R11311 T15166 T15168 nmod [,]
R11312 T15167 T15168 nummod 48,]
R11313 T15168 T15162 conj ],described
R11314 T15169 T15132 punct .,crossed
R11315 T15170 T15172 nsubjpass Mice,housed
R11316 T15171 T15172 auxpass were,housed
R11317 T15172 T15172 ROOT housed,housed
R11318 T15173 T15172 prep in,housed
R11319 T15174 T15175 advmod individually,ventilated
R11320 T15175 T15176 amod ventilated,cages
R11321 T15176 T15173 pobj cages,in
R11322 T15177 T15172 prep at,housed
R11323 T15178 T15180 det the,Department
R11324 T15179 T15180 compound VIB,Department
R11325 T15180 T15177 pobj Department,at
R11326 T15181 T15180 prep of,Department
R11327 T15182 T15184 compound Molecular,Research
R11328 T15183 T15184 compound Biomedical,Research
R11329 T15184 T15181 pobj Research,of
R11330 T15185 T15180 prep in,Department
R11331 T15186 T15189 amod specific,facilities
R11332 T15187 T15189 amod pathogen-free,facilities
R11333 T15188 T15189 compound animal,facilities
R11334 T15189 T15185 pobj facilities,in
R11335 T15190 T15172 punct .,housed
R11336 T15191 T15192 compound Influenza,infections
R11337 T15192 T15194 nsubjpass infections,performed
R11338 T15193 T15194 auxpass were,performed
R11339 T15194 T15194 ROOT performed,performed
R11340 T15195 T15194 prep on,performed
R11341 T15196 T15195 pobj age,on
R11342 T15197 T15194 punct -,performed
R11343 T15198 T15194 punct (,performed
R11344 T15199 T15200 quantmod between,7
R11345 T15200 T15203 nummod 7,weeks
R11346 T15201 T15200 cc and,7
R11347 T15202 T15200 conj 9,7
R11348 T15203 T15204 npadvmod weeks,old
R11349 T15204 T15194 parataxis old,performed
R11350 T15205 T15194 punct ),performed
R11351 T15206 T15194 cc and,performed
R11352 T15207 T15208 amod sex-matched,littermates
R11353 T15208 T15194 conj littermates,performed
R11354 T15209 T15194 punct .,performed
R11355 T15210 T15211 compound A20fl/fl,LysM-Cre
R11356 T15211 T15212 compound LysM-Cre,animals
R11357 T15212 T15214 nsubjpass animals,backcrossed
R11358 T15213 T15214 auxpass were,backcrossed
R11359 T15214 T15214 ROOT backcrossed,backcrossed
R11360 T15215 T15216 nummod three,times
R11361 T15216 T15214 npadvmod times,backcrossed
R11362 T15217 T15214 prep to,backcrossed
R11363 T15218 T15220 det the,background
R11364 T15219 T15220 compound C57Bl/6,background
R11365 T15220 T15217 pobj background,to
R11366 T15221 T15214 punct .,backcrossed
R11367 T15222 T15223 amod A20fl/fl,mice
R11368 T15223 T15231 nsubjpass mice,termed
R11369 T15224 T15223 acl expressing,mice
R11370 T15225 T15224 cc or,expressing
R11371 T15226 T15224 conj lacking,expressing
R11372 T15227 T15229 det the,transgene
R11373 T15228 T15229 compound LysM-Cre,transgene
R11374 T15229 T15231 nsubjpass transgene,termed
R11375 T15230 T15231 auxpass were,termed
R11376 T15231 T15231 ROOT termed,termed
R11377 T15232 T15235 amod A20myel-KO,type
R11378 T15233 T15232 cc and,A20myel-KO
R11379 T15234 T15232 conj wild,A20myel-KO
R11380 T15235 T15231 dobj type,termed
R11381 T15236 T15237 punct (,A20myel-WT
R11382 T15237 T15235 appos A20myel-WT,type
R11383 T15238 T15237 punct ),A20myel-WT
R11384 T15239 T15231 advmod respectively,termed
R11385 T15240 T15231 punct .,termed
R11578 T15476 T15473 punct ;,X-47
R11579 T15477 T15479 compound PR8,A/Victoria/3
R11580 T15478 T15479 compound ×,A/Victoria/3
R11581 T15479 T15480 nsubj A/Victoria/3,/
R11582 T15480 T15471 parataxis /,adapted
R11583 T15481 T15480 npadvmod 75,/
R11584 T15482 T15480 punct ),/
R11585 T15483 T15484 auxpass was,propagated
R11586 T15484 T15471 conj propagated,adapted
R11587 T15485 T15484 prep in,propagated
R11588 T15486 T15487 compound MDCK,cells
R11589 T15487 T15485 pobj cells,in
R11590 T15488 T15471 punct .,adapted
R11591 T15489 T15495 prep For,anesthetized
R11592 T15490 T15491 amod viral,inoculation
R11593 T15491 T15489 pobj inoculation,For
R11594 T15492 T15495 punct ",",anesthetized
R11595 T15493 T15495 nsubjpass mice,anesthetized
R11596 T15494 T15495 auxpass were,anesthetized
R11597 T15495 T15495 ROOT anesthetized,anesthetized
R11598 T15496 T15495 agent by,anesthetized
R11599 T15497 T15498 amod i.p.,injection
R11600 T15498 T15514 nmod injection,X-47
R11601 T15499 T15498 prep with,injection
R11602 T15500 T15499 pobj ketamine,with
R11603 T15501 T15503 punct (,mg/kg
R11604 T15502 T15503 nummod 12,mg/kg
R11605 T15503 T15514 nmod mg/kg,X-47
R11606 T15504 T15503 punct ),mg/kg
R11607 T15505 T15503 cc and,mg/kg
R11608 T15506 T15503 conj xylazine,mg/kg
R11609 T15507 T15506 punct (,xylazine
R11610 T15508 T15509 nummod 60,mg/kg
R11611 T15509 T15506 appos mg/kg,xylazine
R11612 T15510 T15509 punct ),mg/kg
R11613 T15511 T15506 cc and,xylazine
R11614 T15512 T15513 nummod 50,µl
R11615 T15513 T15514 compound µl,X-47
R11616 T15514 T15496 pobj X-47,by
R11617 T15515 T15514 amod diluted,X-47
R11618 T15516 T15515 prep in,diluted
R11619 T15517 T15516 pobj PBS,in
R11620 T15518 T15519 auxpass was,administered
R11621 T15519 T15495 conj administered,anesthetized
R11622 T15520 T15519 advmod intranasally,administered
R11623 T15521 T15519 punct .,administered
R11624 T15522 T15529 prep For,received
R11625 T15523 T15526 amod lethal,infection
R11652 T15550 T15551 auxpass was,measured
R11653 T15551 T15557 ccomp measured,homogenized
R11654 T15552 T15553 mark as,follows
R11655 T15553 T15551 advcl follows,measured
R11656 T15554 T15557 punct :,homogenized
R11657 T15555 T15556 nsubj lungs,were
R11658 T15556 T15557 auxpass were,homogenized
R11659 T15557 T15557 ROOT homogenized,homogenized
R11660 T15558 T15557 prep with,homogenized
R11661 T15559 T15561 det a,homogenizer
R11662 T15560 T15561 compound Polytron,homogenizer
R11663 T15561 T15558 pobj homogenizer,with
R11664 T15562 T15561 punct (,homogenizer
R11665 T15563 T15561 appos Kinematica,homogenizer
R11666 T15564 T15561 punct ),homogenizer
R11667 T15565 T15557 prep in,homogenized
R11668 T15566 T15565 pobj PBS,in
R11669 T15567 T15557 punct .,homogenized
R11670 T15568 T15570 amod Eight-fold,dilutions
R11671 T15569 T15570 amod serial,dilutions
R11672 T15570 T15575 nsubjpass dilutions,incubated
R11673 T15571 T15570 prep of,dilutions
R11674 T15572 T15573 compound lung,homogenates
R11675 T15573 T15571 pobj homogenates,of
R11676 T15574 T15575 auxpass were,incubated
R11677 T15575 T15575 ROOT incubated,incubated
R11678 T15576 T15575 prep on,incubated
R11679 T15577 T15578 compound MDCK,cells
R11680 T15578 T15576 pobj cells,on
R11681 T15579 T15575 prep for,incubated
R11682 T15580 T15581 nummod 5,days
R11683 T15581 T15579 pobj days,for
R11684 T15582 T15581 prep in,days
R11685 T15583 T15582 pobj DMEM,in
R11686 T15584 T15575 conj supplemented,incubated
R11687 T15585 T15584 prep with,supplemented
R11688 T15586 T15585 pobj trypsin,with
R11689 T15587 T15591 punct (,ml
R11690 T15588 T15589 nummod 1,µg
R11691 T15589 T15591 nmod µg,ml
R11692 T15590 T15591 compound /,ml
R11693 T15591 T15586 appos ml,trypsin
R11694 T15592 T15591 punct ),ml
R11695 T15593 T15586 punct ",",trypsin
R11696 T15594 T15596 nummod 2,L-glutamine
R11697 T15595 T15596 compound mM,L-glutamine
R11698 T15596 T15586 appos L-glutamine,trypsin
R11699 T15597 T15596 punct ",",L-glutamine
R11700 T15598 T15601 nummod 0.4,pyruvate
R11701 T15599 T15601 compound mM,pyruvate
R11702 T15600 T15601 compound sodium,pyruvate
R11703 T15601 T15596 appos pyruvate,L-glutamine
R11704 T15602 T15601 cc and,pyruvate
R11705 T15603 T15601 conj antibiotics,pyruvate
R11706 T15604 T15575 punct .,incubated
R11707 T15605 T15618 prep For,added
R11708 T15606 T15605 pobj read-out,For
R11709 T15607 T15618 punct ",",added
R11710 T15608 T15609 nummod 0.5,%
R11711 T15609 T15618 nsubjpass %,added
R11712 T15610 T15613 amod chicken,cells
R11713 T15611 T15613 amod red,cells
R11714 T15612 T15613 compound blood,cells
R11715 T15613 T15609 appos cells,%
R11716 T15614 T15615 punct (,RBC
R11717 T15615 T15613 appos RBC,cells
R11718 T15616 T15613 punct ),cells
R11719 T15617 T15618 auxpass were,added
R11720 T15618 T15618 ROOT added,added
R11721 T15619 T15618 cc and,added
R11722 T15620 T15618 conj end-point,added
R11723 T15621 T15625 nsubjpass dilution,monitored
R11724 T15622 T15621 prep of,dilution
R11725 T15623 T15622 pobj hemagglutination,of
R11726 T15624 T15625 auxpass was,monitored
R11727 T15625 T15618 conj monitored,added
R11728 T15626 T15625 punct .,monitored
R11729 T15627 T15628 nummod TCID50,titers
R11730 T15628 T15631 nsubjpass titers,calculated
R11731 T15629 T15631 auxpass were,calculated
R11732 T15630 T15631 advmod then,calculated
R11733 T15631 T15631 ROOT calculated,calculated
R11734 T15632 T15631 prep according,calculated
R11735 T15633 T15632 prep to,according
R11736 T15634 T15635 det the,method
R11737 T15635 T15633 pobj method,to
R11738 T15636 T15635 prep of,method
R11739 T15637 T15636 pobj Reed,of
R11740 T15638 T15637 cc and,Reed
R11741 T15639 T15640 compound Muench,[
R11742 T15640 T15637 conj [,Reed
R11743 T15641 T15642 nummod 85,]
R11744 T15642 T15635 appos ],method
R11745 T15643 T15631 punct .,calculated
R11947 T15875 T15876 auxpass were,treated
R11948 T15876 T15887 ccomp treated,remove
R11949 T15877 T15876 prep with,treated
R11950 T15878 T15879 amod receptor-destroying,enzyme
R11951 T15879 T15877 pobj enzyme,with
R11952 T15880 T15879 punct (,enzyme
R11953 T15881 T15882 compound RDE/Cholera,filtrate
R11954 T15882 T15879 appos filtrate,enzyme
R11955 T15883 T15887 punct ;,remove
R11956 T15884 T15887 nsubj Sigma,remove
R11957 T15885 T15884 punct ),Sigma
R11958 T15886 T15887 aux to,remove
R11959 T15887 T15887 ROOT remove,remove
R11960 T15888 T15889 amod sialic,acids
R11961 T15889 T15887 dobj acids,remove
R11962 T15890 T15887 prep from,remove
R11963 T15891 T15892 compound serum,proteins
R11964 T15892 T15890 pobj proteins,from
R11965 T15893 T15892 amod capable,proteins
R11966 T15894 T15893 prep of,capable
R11967 T15895 T15896 amod aspecific,inhibition
R11968 T15896 T15894 pobj inhibition,of
R11969 T15897 T15896 prep of,inhibition
R11970 T15898 T15897 pobj agglutination,of
R11971 T15899 T15887 punct .,remove
R11972 T15900 T15911 prep After,inactivated
R11973 T15901 T15902 compound incubation,overnight
R11974 T15902 T15900 pobj overnight,After
R11975 T15903 T15902 prep at,overnight
R11976 T15904 T15905 nummod 37,°
R11977 T15905 T15906 nummod °,C
R11978 T15906 T15903 pobj C,at
R11979 T15907 T15911 punct ",",inactivated
R11980 T15908 T15909 det the,RDE
R11981 T15909 T15911 nsubjpass RDE,inactivated
R11982 T15910 T15911 auxpass was,inactivated
R11983 T15911 T15911 ROOT inactivated,inactivated
R11984 T15912 T15911 agent by,inactivated
R11985 T15913 T15912 pobj addition,by
R11986 T15914 T15913 prep of,addition
R11987 T15915 T15916 nummod 0.75,%
R11988 T15916 T15918 compound %,citrate
R11989 T15917 T15918 compound sodium,citrate
R11990 T15918 T15914 pobj citrate,of
R11991 T15919 T15918 prep in,citrate
R11992 T15920 T15919 pobj PBS,in
R11993 T15921 T15918 cc and,citrate
R11994 T15922 T15918 conj heating,citrate
R11995 T15923 T15911 prep to,inactivated
R11996 T15924 T15925 compound 56,°
R11997 T15925 T15926 nummod °,C
R11998 T15926 T15923 pobj C,to
R11999 T15927 T15911 prep for,inactivated
R12000 T15928 T15929 nummod 30,min
R12001 T15929 T15927 pobj min,for
R12002 T15930 T15911 punct .,inactivated
R12003 T15931 T15932 aux To,remove
R12004 T15932 T15940 advcl remove,cleared
R12005 T15933 T15934 amod sialic,acid
R12006 T15934 T15936 amod acid,proteins
R12007 T15935 T15936 amod binding,proteins
R12008 T15936 T15932 dobj proteins,remove
R12009 T15937 T15940 punct ",",cleared
R12010 T15938 T15940 nsubjpass sera,cleared
R12011 T15939 T15940 auxpass were,cleared
R12012 T15940 T15940 ROOT cleared,cleared
R12013 T15941 T15940 prep with,cleared
R12014 T15942 T15943 amod 1/10,volume
R12015 T15943 T15941 pobj volume,with
R12016 T15944 T15945 nummod 50,%
R12017 T15945 T15947 compound %,RBC
R12018 T15946 T15947 compound chicken,RBC
R12019 T15947 T15943 appos RBC,volume
R12020 T15948 T15940 punct .,cleared
R12021 T15949 T15951 nsubjpass Titration,done
R12022 T15950 T15951 auxpass was,done
R12023 T15951 T15951 ROOT done,done
R12024 T15952 T15951 prep by,done
R12025 T15953 T15952 pcomp incubating,by
R12026 T15954 T15957 det a,series
R12027 T15955 T15957 amod two-fold,series
R12028 T15956 T15957 compound dilution,series
R12029 T15957 T15953 dobj series,incubating
R12030 T15958 T15957 prep of,series
R12031 T15959 T15958 pobj sera,of
R12032 T15960 T15957 prep with,series
R12033 T15961 T15963 nummod 4,units
R12034 T15962 T15963 compound HA,units
R12035 T15963 T15960 pobj units,with
R12036 T15964 T15963 prep of,units
R12037 T15965 T15966 compound X-47,virus
R12038 T15966 T15964 pobj virus,of
R12039 T15967 T15953 prep for,incubating
R12040 T15968 T15969 nummod 1,hour
R12041 T15969 T15967 pobj hour,for
R12042 T15970 T15953 prep at,incubating
R12043 T15971 T15972 compound room,temperature
R12044 T15972 T15970 pobj temperature,at
R12045 T15973 T15972 prep in,temperature
R12046 T15974 T15976 amod 96-well,plates
R12047 T15975 T15976 compound U-bottom,plates
R12048 T15976 T15973 pobj plates,in
R12049 T15977 T15951 punct .,done
R12050 T15978 T15989 advmod Finally,added
R12051 T15979 T15989 punct ",",added
R12052 T15980 T15982 det an,volume
R12053 T15981 T15982 amod equal,volume
R12054 T15982 T15989 nsubjpass volume,added
R12055 T15983 T15982 prep of,volume
R12056 T15984 T15985 nummod 0.5,%
R12057 T15985 T15987 compound %,RBC
R12058 T15986 T15987 compound chicken,RBC
R12059 T15987 T15983 pobj RBC,of
R12060 T15988 T15989 auxpass was,added
R12061 T15989 T15989 ROOT added,added
R12062 T15990 T15989 cc and,added
R12063 T15991 T15993 nsubjpass titers,read
R12064 T15992 T15993 auxpass were,read
R12065 T15993 T15989 conj read,added
R12066 T15994 T15995 nummod 30,min
R12067 T15995 T15996 npadvmod min,later
R12068 T15996 T15993 advmod later,read
R12069 T15997 T15993 punct .,read
R12070 T15998 T15999 amod Negative,controls
R12071 T15999 T16000 nsubj controls,included
R12072 T16000 T16000 ROOT included,included
R12073 T16001 T16000 dobj PBS,included
R12074 T16002 T16003 advmod instead,of
R12075 T16003 T16001 cc of,PBS
R12076 T16004 T16005 amod immune,serum
R12077 T16005 T16003 pobj serum,of
R12078 T16006 T16008 punct (,control
R12079 T16007 T16008 compound agglutination,control
R12080 T16008 T16005 appos control,serum
R12081 T16009 T16008 punct ),control
R12082 T16010 T16005 cc or,serum
R12083 T16011 T16005 conj PR8,serum
R12084 T16012 T16013 advmod instead,of
R12085 T16013 T16005 prep of,serum
R12086 T16014 T16015 compound X-47,virus
R12087 T16015 T16013 pobj virus,of
R12088 T16016 T16017 punct (,control
R12089 T16017 T16001 conj control,PBS
R12090 T16018 T16017 prep for,control
R12091 T16019 T16020 compound agglutination,effect
R12092 T16020 T16018 pobj effect,for
R12093 T16021 T16020 prep of,effect
R12094 T16022 T16021 pobj sera,of
R12095 T16023 T16001 punct ),PBS
R12096 T16024 T16033 punct ;,infected
R12097 T16025 T16033 prep as,infected
R12098 T16026 T16027 amod positive,control
R12099 T16027 T16025 pobj control,as
R12100 T16028 T16033 punct ",",infected
R12101 T16029 T16033 nsubj serum,infected
R12102 T16030 T16029 prep from,serum
R12103 T16031 T16032 det a,mouse
R12104 T16032 T16030 pobj mouse,from
R12105 T16033 T16042 nsubjpass infected,used
R12106 T16034 T16033 advmod twice,infected
R12107 T16035 T16033 prep with,infected
R12108 T16036 T16038 det a,dose
R12109 T16037 T16038 amod sublethal,dose
R12110 T16038 T16035 pobj dose,with
R12111 T16039 T16038 prep of,dose
R12112 T16040 T16039 pobj X-47,of
R12113 T16041 T16042 auxpass was,used
R12114 T16042 T16000 conj used,included
R12115 T16043 T16042 punct .,used
R12261 T16270 T16290 prep In,expressing
R12262 T16271 T16273 compound vivo,GrB
R12263 T16272 T16273 compound intracellular,GrB
R12264 T16273 T16270 pobj GrB,In
R12265 T16274 T16273 cc and,GrB
R12266 T16275 T16276 compound IFNγ,staining
R12267 T16276 T16290 nsubj staining,expressing
R12268 T16277 T16276 prep of,staining
R12269 T16278 T16282 amod activated,cells
R12270 T16279 T16282 quantmod CD8,cells
R12271 T16280 T16282 nummod +,cells
R12272 T16281 T16282 compound T,cells
R12273 T16282 T16277 pobj cells,of
R12274 T16283 T16284 compound Granzyme,B
R12275 T16284 T16290 nsubj B,expressing
R12276 T16285 T16284 punct (,B
R12277 T16286 T16284 appos GrB,B
R12278 T16287 T16284 punct ),B
R12279 T16288 T16284 cc and,B
R12280 T16289 T16284 conj IFNγ,B
R12281 T16290 T16296 csubjpass expressing,determined
R12282 T16291 T16294 nummod CD8,cells
R12283 T16292 T16294 nummod +,cells
R12284 T16293 T16294 compound T,cells
R12285 T16294 T16290 dobj cells,expressing
R12286 T16295 T16296 auxpass were,determined
R12287 T16296 T16296 ROOT determined,determined
R12288 T16297 T16296 prep by,determined
R12289 T16298 T16297 pcomp treating,by
R12290 T16299 T16300 det the,mice
R12291 T16300 T16298 dobj mice,treating
R12292 T16301 T16298 advmod intranasally,treating
R12293 T16302 T16298 prep with,treating
R12294 T16303 T16304 nummod 50,µg
R12295 T16304 T16306 compound µg,A
R12296 T16305 T16306 compound Brefeldin,A
R12297 T16306 T16302 pobj A,with
R12298 T16307 T16306 punct (,A
R12299 T16308 T16306 appos Sigma,A
R12300 T16309 T16306 punct ),A
R12301 T16310 T16312 mark as,described
R12302 T16311 T16312 advmod previously,described
R12303 T16312 T16298 advcl described,treating
R12304 T16313 T16315 nmod [,]
R12305 T16314 T16315 nummod 86,]
R12306 T16315 T16312 dobj ],described
R12307 T16316 T16296 punct .,determined
R12308 T16317 T16318 nummod 6,h
R12309 T16318 T16319 npadvmod h,later
R12310 T16319 T16324 advmod later,were
R12311 T16320 T16324 punct ",",were
R12312 T16321 T16324 nsubj BAL,were
R12313 T16322 T16321 cc and,BAL
R12314 T16323 T16321 conj lungs,BAL
R12315 T16324 T16324 ROOT were,were
R12316 T16325 T16324 acomp isolated,were
R12317 T16326 T16325 cc and,isolated
R12318 T16327 T16329 amod single,suspensions
R12319 T16328 T16329 compound cell,suspensions
R12320 T16329 T16331 nsubjpass suspensions,prepared
R12321 T16330 T16331 auxpass were,prepared
R12322 T16331 T16325 conj prepared,isolated
R12323 T16332 T16331 prep from,prepared
R12324 T16333 T16334 det the,lung
R12325 T16334 T16332 pobj lung,from
R12326 T16335 T16334 prep in,lung
R12327 T16336 T16337 det the,presence
R12328 T16337 T16335 pobj presence,in
R12329 T16338 T16337 prep of,presence
R12330 T16339 T16340 nummod 3,µg
R12331 T16340 T16342 compound µg,ml
R12332 T16341 T16342 compound /,ml
R12333 T16342 T16345 compound ml,Cells
R12334 T16343 T16345 compound Brefeldin,Cells
R12335 T16344 T16345 compound A.,Cells
R12336 T16345 T16338 pobj Cells,of
R12337 T16346 T16347 auxpass were,stained
R12338 T16347 T16331 conj stained,prepared
R12339 T16348 T16347 punct ",",stained
R12340 T16349 T16347 conj fixed,stained
R12341 T16350 T16349 cc and,fixed
R12342 T16351 T16349 conj permeabilized,fixed
R12343 T16352 T16358 punct (,according
R12344 T16353 T16358 dep Cytofix/Cytoperm,according
R12345 T16354 T16353 punct ",",Cytofix/Cytoperm
R12346 T16355 T16356 compound BD,Biosciences
R12347 T16356 T16353 appos Biosciences,Cytofix/Cytoperm
R12348 T16357 T16358 punct ),according
R12349 T16358 T16324 prep according,were
R12350 T16359 T16358 prep to,according
R12351 T16360 T16361 det the,manufacturer
R12352 T16361 T16363 poss manufacturer,instructions
R12353 T16362 T16361 case 's,manufacturer
R12354 T16363 T16359 pobj instructions,to
R12355 T16364 T16324 punct .,were
R12356 T16365 T16369 amod Activated,cells
R12357 T16366 T16369 nummod CD8,cells
R12358 T16367 T16369 nummod +,cells
R12359 T16368 T16369 compound T,cells
R12360 T16369 T16371 nsubjpass cells,analyzed
R12361 T16370 T16371 auxpass were,analyzed
R12362 T16371 T16371 ROOT analyzed,analyzed
R12363 T16372 T16371 agent by,analyzed
R12364 T16373 T16374 compound flow,cytometry
R12365 T16374 T16372 pobj cytometry,by
R12366 T16375 T16371 prep based,analyzed
R12367 T16376 T16375 prep on,based
R12368 T16377 T16379 compound CD62lo,+
R12369 T16378 T16379 compound CD3,+
R12370 T16379 T16376 pobj +,on
R12371 T16380 T16379 cc and,+
R12372 T16381 T16379 conj CD8,+
R12373 T16382 T16383 compound +,expression
R12374 T16383 T16383 ROOT expression,expression
R12375 T16384 T16371 punct .,analyzed
R12376 T16385 T16391 amod Live/Dead,kit
R12377 T16386 T16391 amod fixable,kit
R12378 T16387 T16390 compound aqua,stain
R12379 T16388 T16389 amod dead,cell
R12380 T16389 T16390 compound cell,stain
R12381 T16390 T16391 compound stain,kit
R12382 T16391 T16397 nsubjpass kit,used
R12383 T16392 T16394 punct (,Probes
R12384 T16393 T16394 compound Molecular,Probes
R12385 T16394 T16391 appos Probes,kit
R12386 T16395 T16394 punct ),Probes
R12387 T16396 T16397 auxpass was,used
R12388 T16397 T16397 ROOT used,used
R12389 T16398 T16399 aux to,discriminate
R12390 T16399 T16397 xcomp discriminate,used
R12391 T16400 T16399 advmod live,discriminate
R12392 T16401 T16400 prep from,live
R12393 T16402 T16403 amod dead,cells
R12394 T16403 T16401 pobj cells,from
R12395 T16404 T16397 punct .,used
R12667 T16819 T16827 nsubjpass Cells,grown
R12668 T16820 T16819 cc and,Cells
R12669 T16821 T16819 conj transfection,Cells
R12670 T16822 T16821 dobj HEK293T,transfection
R12671 T16823 T16821 cc and,transfection
R12672 T16824 T16821 conj MDCK,transfection
R12673 T16825 T16819 conj cells,Cells
R12674 T16826 T16827 auxpass were,grown
R12675 T16827 T16827 ROOT grown,grown
R12676 T16828 T16827 prep in,grown
R12677 T16829 T16828 pobj DMEM,in
R12678 T16830 T16829 punct (,DMEM
R12679 T16831 T16829 appos Gibco,DMEM
R12680 T16832 T16829 punct ),DMEM
R12681 T16833 T16827 conj supplemented,grown
R12682 T16834 T16833 prep with,supplemented
R12683 T16835 T16836 nummod 10,%
R12684 T16836 T16837 compound %,FCS
R12685 T16837 T16834 pobj FCS,with
R12686 T16838 T16837 punct ",",FCS
R12687 T16839 T16841 nummod 2,L-glutamine
R12688 T16840 T16841 compound mM,L-glutamine
R12689 T16841 T16837 conj L-glutamine,FCS
R12690 T16842 T16841 punct ",",L-glutamine
R12691 T16843 T16846 nummod 0.4,pyruvate
R12692 T16844 T16846 compound mM,pyruvate
R12693 T16845 T16846 compound sodium,pyruvate
R12694 T16846 T16841 appos pyruvate,L-glutamine
R12695 T16847 T16846 cc and,pyruvate
R12696 T16848 T16846 conj antibiotics,pyruvate
R12697 T16849 T16827 punct .,grown
R12698 T16850 T16851 nummod HEK293T,cells
R12699 T16851 T16853 nsubjpass cells,transfected
R12700 T16852 T16853 auxpass were,transfected
R12701 T16853 T16853 ROOT transfected,transfected
R12702 T16854 T16853 advcl using,transfected
R12703 T16855 T16860 det the,method
R12704 T16856 T16858 nsubj calcium,precipitate
R12705 T16857 T16858 compound phosphate,precipitate
R12706 T16858 T16860 compound precipitate,method
R12707 T16859 T16860 compound transfection,method
R12708 T16860 T16854 dobj method,using
R12709 T16861 T16854 prep with,using
R12710 T16862 T16864 amod specific,vectors
R12711 T16863 T16864 compound expression,vectors
R12712 T16864 T16861 pobj vectors,with
R12713 T16865 T16866 punct (,pCAGGS-E-hA20
R12714 T16866 T16864 appos pCAGGS-E-hA20,vectors
R12715 T16867 T16868 punct (,LMBP
R12716 T16868 T16866 dep LMBP,pCAGGS-E-hA20
R12717 T16869 T16868 nummod 3778,LMBP
R12718 T16870 T16868 punct ),LMBP
R12719 T16871 T16868 punct ",",LMBP
R12720 T16872 T16868 conj pCAGGS-E-RIG-I-CARD,LMBP
R12721 T16873 T16872 punct (,pCAGGS-E-RIG-I-CARD
R12722 T16874 T16872 appos LMBP,pCAGGS-E-RIG-I-CARD
R12723 T16875 T16874 nummod 6517,LMBP
R12724 T16876 T16872 punct ),pCAGGS-E-RIG-I-CARD
R12725 T16877 T16872 punct ",",pCAGGS-E-RIG-I-CARD
R12726 T16878 T16872 conj pEF-HA-IRF-7,pCAGGS-E-RIG-I-CARD
R12727 T16879 T16881 punct (,provided
R12728 T16880 T16881 advmod kindly,provided
R12729 T16881 T16868 parataxis provided,LMBP
R12730 T16882 T16881 agent by,provided
R12731 T16883 T16884 compound T.,Taniguchi
R12732 T16884 T16887 poss Taniguchi,School
R12733 T16885 T16884 punct ",",Taniguchi
R12734 T16886 T16887 compound Graduate,School
R12735 T16887 T16882 pobj School,by
R12736 T16888 T16887 prep of,School
R12737 T16889 T16888 pobj Medicine,of
R12738 T16890 T16889 cc and,Medicine
R12739 T16891 T16889 conj Faculty,Medicine
R12740 T16892 T16891 prep of,Faculty
R12741 T16893 T16892 pobj Medicine,of
R12742 T16894 T16891 punct ",",Faculty
R12743 T16895 T16887 conj University,School
R12744 T16896 T16895 prep of,University
R12745 T16897 T16896 pobj Tokyo,of
R12746 T16898 T16895 punct ),University
R12747 T16899 T16887 punct ),School
R12748 T16900 T16887 punct ",",School
R12749 T16901 T16887 conj NF-κB,School
R12750 T16902 T16901 punct ",",NF-κB
R12751 T16903 T16901 conj IRF3,NF-κB
R12752 T16904 T16903 punct ",",IRF3
R12753 T16905 T16906 compound IRF7,reporter
R12754 T16906 T16907 compound reporter,plasmids
R12755 T16907 T16903 conj plasmids,IRF3
R12756 T16908 T16907 punct (,plasmids
R12757 T16909 T16910 advmod respectively,pConLuc
R12758 T16910 T16907 appos pConLuc,plasmids
R12759 T16911 T16912 punct (,LMBP3248
R12760 T16912 T16910 appos LMBP3248,pConLuc
R12761 T16913 T16910 punct ),pConLuc
R12762 T16914 T16910 punct ",",pConLuc
R12763 T16915 T16910 conj pISRE-luc,pConLuc
R12764 T16916 T16917 punct (,LMBP4011
R12765 T16917 T16915 appos LMBP4011,pISRE-luc
R12766 T16918 T16915 punct ),pISRE-luc
R12767 T16919 T16915 punct ",",pISRE-luc
R12768 T16920 T16915 conj pGL3-IFNα4-luc,pISRE-luc
R12769 T16921 T16923 punct (,provided
R12770 T16922 T16923 advmod kindly,provided
R12771 T16923 T16907 parataxis provided,plasmids
R12772 T16924 T16923 agent by,provided
R12773 T16925 T16926 compound J.,Hiscott
R12774 T16926 T16924 pobj Hiscott,by
R12775 T16927 T16926 punct ",",Hiscott
R12776 T16928 T16929 compound McGill,University
R12777 T16929 T16926 conj University,Hiscott
R12778 T16930 T16929 punct ",",University
R12779 T16931 T16929 conj Montreal,University
R12780 T16932 T16931 punct ",",Montreal
R12781 T16933 T16931 conj Quebec,Montreal
R12782 T16934 T16933 punct ",",Quebec
R12783 T16935 T16933 conj Canada,Quebec
R12784 T16936 T16933 punct ),Quebec
R12785 T16937 T16931 punct ",",Montreal
R12786 T16938 T16931 cc and,Montreal
R12787 T16939 T16931 conj pACTbetagal,Montreal
R12788 T16940 T16941 punct (,LMBP4341
R12789 T16941 T16939 appos LMBP4341,pACTbetagal
R12790 T16942 T16939 punct ),pACTbetagal
R12791 T16943 T16923 prep for,provided
R12792 T16944 T16946 compound transfection,normalization
R12793 T16945 T16946 compound efficiency,normalization
R12794 T16946 T16943 pobj normalization,for
R12795 T16947 T16853 punct .,transfected
R12796 T16948 T16952 nsubjpass Details,presented
R12797 T16949 T16948 prep of,Details
R12798 T16950 T16949 pobj plasmids,of
R12799 T16951 T16952 auxpass are,presented
R12800 T16952 T16952 ROOT presented,presented
R12801 T16953 T16952 prep along,presented
R12802 T16954 T16952 prep with,presented
R12803 T16955 T16957 amod detailed,maps
R12804 T16956 T16957 compound sequence,maps
R12805 T16957 T16954 pobj maps,with
R12806 T16958 T16957 prep at,maps
R12807 T16959 T16963 det the,http://bccm.belspo.be/index.php
R12808 T16960 T16963 compound BCCM-LMBP,http://bccm.belspo.be/index.php
R12809 T16961 T16962 compound plasmid,databank
R12810 T16962 T16963 compound databank,http://bccm.belspo.be/index.php
R12811 T16963 T16958 pobj http://bccm.belspo.be/index.php,at
R12812 T16964 T16952 punct .,presented
R12813 T16965 T16975 prep For,cultured
R12814 T16966 T16967 det the,generation
R12815 T16967 T16965 pobj generation,For
R12816 T16968 T16967 prep of,generation
R12817 T16969 T16968 pobj BMDM,of
R12818 T16970 T16969 punct ",",BMDM
R12819 T16971 T16972 compound bone,marrow
R12820 T16972 T16973 compound marrow,cells
R12821 T16973 T16975 nsubjpass cells,cultured
R12822 T16974 T16975 auxpass were,cultured
R12823 T16975 T16975 ROOT cultured,cultured
R12824 T16976 T16977 nummod 7,days
R12825 T16977 T16975 npadvmod days,cultured
R12826 T16978 T16975 prep in,cultured
R12827 T16979 T16984 nsubj RPMI,supplemented
R12828 T16980 T16979 nummod 1640,RPMI
R12829 T16981 T16982 punct (,Gibco
R12830 T16982 T16979 appos Gibco,RPMI
R12831 T16983 T16979 punct ),RPMI
R12832 T16984 T16975 conj supplemented,cultured
R12833 T16985 T16984 prep with,supplemented
R12834 T16986 T16987 nummod 10,%
R12835 T16987 T16988 compound %,FCS
R12836 T16988 T16985 pobj FCS,with
R12837 T16989 T16988 punct ",",FCS
R12838 T16990 T16992 nummod 2,L-glutamine
R12839 T16991 T16992 compound mM,L-glutamine
R12840 T16992 T16988 conj L-glutamine,FCS
R12841 T16993 T16992 punct ",",L-glutamine
R12842 T16994 T16997 nummod 0.4,pyruvate
R12843 T16995 T16997 compound mM,pyruvate
R12844 T16996 T16997 compound sodium,pyruvate
R12845 T16997 T16992 appos pyruvate,L-glutamine
R12846 T16998 T16997 punct ",",pyruvate
R12847 T16999 T16997 conj antibiotics,pyruvate
R12848 T17000 T16999 cc and,antibiotics
R12849 T17001 T17004 nummod 40,M-CSF
R12850 T17002 T17003 advmod ng/ml,recombinant
R12851 T17003 T17004 amod recombinant,M-CSF
R12852 T17004 T16999 conj M-CSF,antibiotics
R12853 T17005 T16984 punct .,supplemented
R12854 T17006 T17007 nsubj BMDM,were
R12855 T17007 T17007 ROOT were,were
R12856 T17008 T17007 prep of,were
R12857 T17009 T17012 nummod ≥,purity
R12858 T17010 T17011 nummod 95,%
R12859 T17011 T17012 compound %,purity
R12860 T17012 T17008 pobj purity,of
R12861 T17013 T17014 mark as,measured
R12862 T17014 T17007 advcl measured,were
R12863 T17015 T17014 agent by,measured
R12864 T17016 T17017 compound flow,cytometry
R12865 T17017 T17015 pobj cytometry,by
R12866 T17018 T17014 advcl using,measured
R12867 T17019 T17023 nmod F4/80,antibodies
R12868 T17020 T17019 cc and,F4/80
R12869 T17021 T17019 conj CD11b,F4/80
R12870 T17022 T17023 amod specific,antibodies
R12871 T17023 T17018 dobj antibodies,using
R12872 T17024 T17007 punct .,were
R12873 T17025 T17034 prep For,was
R12874 T17026 T17027 det the,isolation
R12875 T17027 T17025 pobj isolation,For
R12876 T17028 T17027 prep of,isolation
R12877 T17029 T17030 amod alveolar,macrophages
R12878 T17030 T17028 pobj macrophages,of
R12879 T17031 T17034 punct ",",was
R12880 T17032 T17033 det the,trachea
R12881 T17033 T17034 nsubj trachea,was
R12882 T17034 T17034 ROOT was,was
R12883 T17035 T17034 attr canulated,was
R12884 T17036 T17035 cc and,canulated
R12885 T17037 T17038 det the,lung
R12886 T17038 T17040 nsubjpass lung,flushed
R12887 T17039 T17040 auxpass was,flushed
R12888 T17040 T17035 conj flushed,canulated
R12889 T17041 T17042 nummod 4,times
R12890 T17042 T17040 npadvmod times,flushed
R12891 T17043 T17040 prep with,flushed
R12892 T17044 T17043 pobj HBSS,with
R12893 T17045 T17040 advcl containing,flushed
R12894 T17046 T17048 nummod 1,EDTA
R12895 T17047 T17048 compound mM,EDTA
R12896 T17048 T17045 dobj EDTA,containing
R12897 T17049 T17034 punct .,was
R12898 T17050 T17051 compound Alveolar,macrophages
R12899 T17051 T17060 nsubjpass macrophages,supplemented
R12900 T17052 T17060 ccomp were,supplemented
R12901 T17053 T17052 acomp cultured,were
R12902 T17054 T17053 prep in,cultured
R12903 T17055 T17060 nsubj RPMI,supplemented
R12904 T17056 T17055 nummod 1640,RPMI
R12905 T17057 T17058 punct (,Gibco
R12906 T17058 T17055 appos Gibco,RPMI
R12907 T17059 T17060 punct ),supplemented
R12908 T17060 T17060 ROOT supplemented,supplemented
R12909 T17061 T17060 prep with,supplemented
R12910 T17062 T17063 nummod 1,%
R12911 T17063 T17064 compound %,FCS
R12914 T17066 T17068 nummod 2,L-glutamine
R12915 T17067 T17068 compound mM,L-glutamine
R12916 T17068 T17064 conj L-glutamine,FCS
R12917 T17069 T17068 punct ",",L-glutamine
R12918 T17070 T17073 nummod 0.4,pyruvate
R12919 T17071 T17073 compound mM,pyruvate
R12920 T17072 T17073 compound sodium,pyruvate
R12921 T17073 T17068 appos pyruvate,L-glutamine
R12922 T17074 T17073 cc and,pyruvate
R12923 T17075 T17073 conj antibiotics,pyruvate
R12924 T17076 T17060 punct .,supplemented
R13226 T17442 T17443 amod Western,blotting
R13227 T17443 T17443 ROOT blotting,blotting
R13228 T17444 T17443 prep For,blotting
R13229 T17445 T17446 amod total,lysates
R13230 T17446 T17444 pobj lysates,For
R13231 T17447 T17450 punct ",",lysed
R13232 T17448 T17450 nsubjpass cells,lysed
R13233 T17449 T17450 auxpass were,lysed
R13234 T17450 T17450 ROOT lysed,lysed
R13235 T17451 T17450 prep at,lysed
R13236 T17452 T17453 nummod 4,°
R13237 T17453 T17451 pobj °,at
R13238 T17454 T17450 dobj C,lysed
R13239 T17455 T17450 prep for,lysed
R13240 T17456 T17457 nummod 15,min
R13241 T17457 T17455 pobj min,for
R13242 T17458 T17457 prep in,min
R13243 T17459 T17460 compound lysis,buffer
R13244 T17460 T17458 pobj buffer,in
R13245 T17461 T17457 punct (,min
R13246 T17462 T17464 nummod 200,NaCl
R13247 T17463 T17464 compound mM,NaCl
R13248 T17464 T17457 appos NaCl,min
R13249 T17465 T17464 punct ",",NaCl
R13250 T17466 T17467 nummod 1,%
R13251 T17467 T17468 compound %,NP-40
R13252 T17468 T17464 appos NP-40,NaCl
R13253 T17469 T17464 punct ",",NaCl
R13254 T17470 T17473 nummod 10,pH
R13255 T17471 T17473 compound mM,pH
R13256 T17472 T17473 compound Tris-HCl,pH
R13257 T17473 T17484 dep pH,supplemented
R13258 T17474 T17473 nummod 7.5,pH
R13259 T17475 T17473 punct ",",pH
R13260 T17476 T17478 nummod 5,EDTA
R13261 T17477 T17478 compound mM,EDTA
R13262 T17478 T17473 appos EDTA,pH
R13263 T17479 T17478 punct ",",EDTA
R13264 T17480 T17482 nummod 2,DTT
R13265 T17481 T17482 compound mM,DTT
R13266 T17482 T17478 appos DTT,EDTA
R13267 T17483 T17484 punct ),supplemented
R13268 T17484 T17484 ROOT supplemented,supplemented
R13269 T17485 T17484 prep with,supplemented
R13270 T17486 T17489 nmod protease,inhibitors
R13271 T17487 T17486 cc and,protease
R13272 T17488 T17486 conj phosphatase,protease
R13273 T17489 T17485 pobj inhibitors,with
R13274 T17490 T17484 punct .,supplemented
R13275 T17491 T17494 amod Nuclear,lysates
R13276 T17492 T17491 cc and,Nuclear
R13277 T17493 T17491 conj cytoplasmic,Nuclear
R13278 T17494 T17496 nsubjpass lysates,prepared
R13279 T17495 T17496 auxpass were,prepared
R13280 T17496 T17496 ROOT prepared,prepared
R13281 T17497 T17496 agent by,prepared
R13282 T17498 T17497 pcomp resuspending,by
R13283 T17499 T17498 dobj cells,resuspending
R13284 T17500 T17498 prep in,resuspending
R13285 T17501 T17500 pobj B1,in
R13286 T17502 T17501 punct (,B1
R13287 T17503 T17506 nummod 10,pH
R13288 T17504 T17506 compound mM,pH
R13289 T17505 T17506 compound Hepes,pH
R13290 T17506 T17501 appos pH,B1
R13291 T17507 T17511 nummod 7.5,KCl
R13292 T17508 T17511 punct ",",KCl
R13293 T17509 T17511 nummod 10,KCl
R13294 T17510 T17511 compound mM,KCl
R13295 T17511 T17501 appos KCl,B1
R13296 T17512 T17511 punct ",",KCl
R13297 T17513 T17515 nummod 1,MgCl2
R13298 T17514 T17515 compound mM,MgCl2
R13299 T17515 T17511 conj MgCl2,KCl
R13300 T17516 T17515 punct ",",MgCl2
R13301 T17517 T17518 nummod 5,%
R13302 T17518 T17519 compound %,glycerol
R13303 T17519 T17515 conj glycerol,MgCl2
R13304 T17520 T17519 punct ",",glycerol
R13305 T17521 T17523 nummod 0.5,EDTA
R13306 T17522 T17523 compound mM,EDTA
R13307 T17523 T17519 appos EDTA,glycerol
R13308 T17524 T17519 cc and,glycerol
R13309 T17525 T17527 nummod 0.1,EGTA
R13310 T17526 T17527 compound mM,EGTA
R13311 T17527 T17528 nsubj EGTA,supplemented
R13312 T17528 T17496 advcl supplemented,prepared
R13313 T17529 T17528 prep with,supplemented
R13314 T17530 T17529 pobj protease,with
R13315 T17531 T17530 cc and,protease
R13316 T17532 T17533 compound phosphatase,inhibitors
R13317 T17533 T17530 conj inhibitors,protease
R13318 T17534 T17528 punct ),supplemented
R13319 T17535 T17528 prep for,supplemented
R13320 T17536 T17537 nummod 15,min
R13321 T17537 T17535 pobj min,for
R13322 T17538 T17528 prep at,supplemented
R13323 T17539 T17540 nummod 4,°
R13324 T17540 T17542 nummod °,Next
R13325 T17541 T17542 compound C.,Next
R13326 T17542 T17538 pobj Next,at
R13327 T17543 T17547 punct ",",added
R13328 T17544 T17545 compound NP-40,detergent
R13329 T17545 T17547 nsubjpass detergent,added
R13330 T17546 T17547 auxpass was,added
R13331 T17547 T17496 conj added,prepared
R13332 T17548 T17547 prep to,added
R13333 T17549 T17551 det a,concentration
R13334 T17550 T17551 amod final,concentration
R13335 T17551 T17548 pobj concentration,to
R13336 T17552 T17551 prep of,concentration
R13337 T17553 T17554 nummod 0.65,%
R13338 T17554 T17552 pobj %,of
R13339 T17555 T17551 cc and,concentration
R13340 T17556 T17551 conj cells,concentration
R13341 T17557 T17558 auxpass were,centrifuged
R13342 T17558 T17547 conj centrifuged,added
R13343 T17559 T17558 prep at,centrifuged
R13344 T17560 T17561 nummod 500,g
R13345 T17561 T17559 pobj g,at
R13346 T17562 T17558 prep for,centrifuged
R13347 T17563 T17564 nummod 5,min
R13348 T17564 T17562 pobj min,for
R13349 T17565 T17547 punct .,added
R13350 T17566 T17568 det The,fraction
R13351 T17567 T17568 amod nuclear,fraction
R13352 T17568 T17571 nsubj fraction,was
R13353 T17569 T17568 acl containing,fraction
R13354 T17570 T17569 dobj pellet,containing
R13355 T17571 T17572 auxpass was,lyzed
R13356 T17572 T17572 ROOT lyzed,lyzed
R13357 T17573 T17572 prep in,lyzed
R13358 T17574 T17573 pobj B2,in
R13359 T17575 T17572 punct (,lyzed
R13360 T17576 T17579 nummod 20,pH
R13361 T17577 T17579 compound mM,pH
R13362 T17578 T17579 compound Hepes,pH
R13363 T17579 T17572 appos pH,lyzed
R13364 T17580 T17579 nummod 7.5,pH
R13365 T17581 T17579 punct ",",pH
R13366 T17582 T17583 nummod 1,%
R13367 T17583 T17584 compound %,NP-40
R13368 T17584 T17579 appos NP-40,pH
R13369 T17585 T17584 punct ",",NP-40
R13370 T17586 T17588 nummod 400,NaCl
R13371 T17587 T17588 compound mM,NaCl
R13372 T17588 T17609 nsubj NaCl,supplemented
R13373 T17589 T17588 punct ",",NaCl
R13374 T17590 T17592 nummod 10,KCl
R13375 T17591 T17592 compound mM,KCl
R13376 T17592 T17588 appos KCl,NaCl
R13377 T17593 T17592 punct ",",KCl
R13378 T17594 T17596 nummod 1,MgCl2
R13379 T17595 T17596 compound mM,MgCl2
R13380 T17596 T17588 appos MgCl2,NaCl
R13381 T17597 T17596 punct ",",MgCl2
R13382 T17598 T17599 nummod 20,%
R13383 T17599 T17600 compound %,glycerol
R13384 T17600 T17596 appos glycerol,MgCl2
R13385 T17601 T17596 punct ",",MgCl2
R13386 T17602 T17604 nummod 0.5,EDTA
R13387 T17603 T17604 compound mM,EDTA
R13388 T17604 T17596 conj EDTA,MgCl2
R13389 T17605 T17604 cc and,EDTA
R13390 T17606 T17608 nummod 0.1,EGTA
R13391 T17607 T17608 compound mM,EGTA
R13392 T17608 T17604 conj EGTA,EDTA
R13393 T17609 T17609 ROOT supplemented,supplemented
R13394 T17610 T17609 prep with,supplemented
R13395 T17611 T17614 nmod protease,inhibitors
R13396 T17612 T17611 cc and,protease
R13397 T17613 T17611 conj phosphatase,protease
R13398 T17614 T17610 pobj inhibitors,with
R13399 T17615 T17609 punct ),supplemented
R13400 T17616 T17609 prep for,supplemented
R13401 T17617 T17618 nummod 15,min
R13402 T17618 T17616 pobj min,for
R13403 T17619 T17609 prep at,supplemented
R13404 T17620 T17621 nummod 4,°
R13405 T17621 T17619 pobj °,at
R13406 T17622 T17609 conj C,supplemented
R13407 T17623 T17609 punct .,supplemented
R13408 T17624 T17625 det The,lysates
R13409 T17625 T17628 nsubjpass lysates,separated
R13410 T17626 T17628 auxpass were,separated
R13411 T17627 T17628 advmod subsequently,separated
R13412 T17628 T17628 ROOT separated,separated
R13413 T17629 T17628 agent by,separated
R13414 T17630 T17629 pobj SDS-PAGE,by
R13415 T17631 T17628 cc and,separated
R13416 T17632 T17628 conj analyzed,separated
R13417 T17633 T17632 agent by,analyzed
R13418 T17634 T17635 amod western,blotting
R13419 T17635 T17633 pobj blotting,by
R13420 T17636 T17635 cc and,blotting
R13421 T17637 T17638 compound ECL,detection
R13422 T17638 T17635 conj detection,blotting
R13423 T17639 T17643 punct (,Sciences
R13424 T17640 T17643 compound Perkin,Sciences
R13425 T17641 T17643 compound Elmer,Sciences
R13426 T17642 T17643 compound Life,Sciences
R13427 T17643 T17638 appos Sciences,detection
R13428 T17644 T17638 punct ),detection
R13429 T17645 T17628 punct .,separated
R13430 T17646 T17648 nsubjpass Immunoblots,revealed
R13431 T17647 T17648 auxpass were,revealed
R13432 T17648 T17648 ROOT revealed,revealed
R13433 T17649 T17648 prep with,revealed
R13434 T17650 T17652 amod anti-A20,anti-IκBα
R13435 T17651 T17650 punct ",",anti-A20
R13436 T17652 T17649 pobj anti-IκBα,with
R13437 T17653 T17652 punct ",",anti-IκBα
R13438 T17654 T17652 conj anti-p65,anti-IκBα
R13439 T17655 T17654 punct ",",anti-p65
R13440 T17656 T17654 cc and,anti-p65
R13441 T17657 T17658 compound anti-histon,H1
R13442 T17658 T17654 conj H1,anti-p65
R13443 T17659 T17658 punct (,H1
R13444 T17660 T17661 compound Santa,Cruz
R13445 T17661 T17658 appos Cruz,H1
R13446 T17662 T17658 punct ),H1
R13447 T17663 T17658 punct ",",H1
R13448 T17664 T17658 conj anti-IRF3,H1
R13449 T17665 T17664 punct (,anti-IRF3
R13450 T17666 T17664 appos Invitrogen,anti-IRF3
R13451 T17667 T17664 punct ),anti-IRF3
R13452 T17668 T17664 punct ",",anti-IRF3
R13453 T17669 T17664 conj anti-phospho-IRF3,anti-IRF3
R13454 T17670 T17669 cc and,anti-phospho-IRF3
R13455 T17671 T17669 conj anti-phospho-IκBα,anti-phospho-IRF3
R13456 T17672 T17674 punct (,Signaling
R13457 T17673 T17674 compound Cell,Signaling
R13458 T17674 T17671 parataxis Signaling,anti-phospho-IκBα
R13459 T17675 T17674 punct ),Signaling
R13460 T17676 T17671 cc and,anti-phospho-IκBα
R13461 T17677 T17671 conj anti-actin,anti-phospho-IκBα
R13462 T17678 T17680 punct (,Biomedicals
R13463 T17679 T17680 compound MP,Biomedicals
R13464 T17680 T17677 appos Biomedicals,anti-actin
R13465 T17681 T17680 punct ),Biomedicals
R13466 T17682 T17648 punct .,revealed
R13467 T17683 T17684 det The,density
R13468 T17684 T17689 nsubjpass density,quantified
R13469 T17685 T17684 prep of,density
R13470 T17686 T17687 det the,bands
R13471 T17687 T17685 pobj bands,of
R13472 T17688 T17689 auxpass was,quantified
R13473 T17689 T17689 ROOT quantified,quantified
R13474 T17690 T17691 punct (,fold
R13475 T17691 T17689 parataxis fold,quantified
R13476 T17692 T17691 dobj induction,fold
R13477 T17693 T17691 punct ),fold
R13478 T17694 T17689 prep with,quantified
R13479 T17695 T17696 det the,ImageJ
R13480 T17696 T17700 nmod ImageJ,Gel
R13481 T17697 T17696 punct (,ImageJ
R13482 T17698 T17696 appos http://rsbweb.nih.gov/ij,ImageJ
R13483 T17699 T17700 punct ),Gel
R13484 T17700 T17702 compound Gel,tool
R13485 T17701 T17702 compound analyzer,tool
R13486 T17702 T17694 pobj tool,with
R13487 T17703 T17689 punct .,quantified
R13488 T17704 T17705 det All,intensities
R13489 T17705 T17707 nsubjpass intensities,calculated
R13490 T17706 T17707 auxpass were,calculated
R13491 T17707 T17707 ROOT calculated,calculated
R13492 T17708 T17707 oprd relative,calculated
R13493 T17709 T17708 prep to,relative
R13494 T17710 T17712 det the,lane
R13495 T17711 T17712 amod first,lane
R13496 T17712 T17709 pobj lane,to
R13497 T17713 T17715 punct (,time
R13498 T17714 T17715 punct =,time
R13499 T17715 T17708 appos time,relative
R13500 T17716 T17715 nummod 0,time
R13501 T17717 T17715 punct ),time
R13502 T17718 T17707 punct .,calculated
R13588 T17947 T17949 compound Flow,Lungs
R13589 T17948 T17949 compound cytometry,Lungs
R13590 T17949 T17951 nsubjpass Lungs,dissected
R13591 T17950 T17951 auxpass were,dissected
R13592 T17951 T17951 ROOT dissected,dissected
R13593 T17952 T17951 cc and,dissected
R13594 T17953 T17951 conj incubated,dissected
R13595 T17954 T17953 prep with,incubated
R13596 T17955 T17956 compound collagenase,type
R13597 T17956 T17957 compound type,IV
R13598 T17957 T17954 pobj IV,with
R13599 T17958 T17960 punct (,mg/ml
R13600 T17959 T17960 nummod 1,mg/ml
R13601 T17960 T17957 appos mg/ml,IV
R13602 T17961 T17962 punct ;,Sigma
R13603 T17962 T17962 ROOT Sigma,Sigma
R13604 T17963 T17962 punct ),Sigma
R13605 T17964 T17962 cc and,Sigma
R13606 T17965 T17962 conj DNAse,Sigma
R13607 T17966 T17968 punct (,U/ml
R13608 T17967 T17968 nummod 100,U/ml
R13609 T17968 T17962 conj U/ml,Sigma
R13610 T17969 T17968 punct ;,U/ml
R13611 T17970 T17968 conj Roche,U/ml
R13612 T17971 T17968 punct ),U/ml
R13613 T17972 T17962 prep at,Sigma
R13614 T17973 T17974 nummod 37,°
R13615 T17974 T17972 pobj °,at
R13616 T17975 T17962 conj C,Sigma
R13617 T17976 T17962 prep for,Sigma
R13618 T17977 T17978 nummod 30,min
R13619 T17978 T17976 pobj min,for
R13620 T17979 T17951 punct .,dissected
R13621 T17980 T17984 advmod Subsequently,filtered
R13622 T17981 T17984 punct ",",filtered
R13623 T17982 T17984 nsubjpass samples,filtered
R13624 T17983 T17984 auxpass were,filtered
R13625 T17984 T17984 ROOT filtered,filtered
R13626 T17985 T17984 prep through,filtered
R13627 T17986 T17988 det a,µm
R13628 T17987 T17988 nummod 70,µm
R13629 T17988 T17985 pobj µm,through
R13630 T17989 T17988 cc and,µm
R13631 T17990 T17991 nummod 40,µm
R13632 T17991 T17993 compound µm,mesh
R13633 T17992 T17993 compound nylon,mesh
R13634 T17993 T17988 conj mesh,µm
R13635 T17994 T17984 punct .,filtered
R13636 T17995 T18003 prep For,canulated
R13637 T17996 T17997 det the,preparation
R13638 T17997 T17995 pobj preparation,For
R13639 T17998 T17997 prep of,preparation
R13640 T17999 T17998 pobj BAL,of
R13641 T18000 T18003 punct ",",canulated
R13642 T18001 T18003 nsubjpass trachea,canulated
R13643 T18002 T18003 auxpass were,canulated
R13644 T18003 T18003 ROOT canulated,canulated
R13645 T18004 T18003 cc and,canulated
R13646 T18005 T18006 compound airway,lumen
R13647 T18006 T18008 nsubjpass lumen,flushed
R13648 T18007 T18008 auxpass was,flushed
R13649 T18008 T18003 conj flushed,canulated
R13650 T18009 T18010 nummod 4,times
R13651 T18010 T18008 npadvmod times,flushed
R13652 T18011 T18008 prep with,flushed
R13653 T18012 T18011 pobj HBSS,with
R13654 T18013 T18008 prep with,flushed
R13655 T18014 T18016 nummod 1,EDTA
R13656 T18015 T18016 compound mM,EDTA
R13657 T18016 T18013 pobj EDTA,with
R13658 T18017 T18008 punct .,flushed
R13659 T18018 T18020 nsubjpass Cells,stained
R13660 T18019 T18020 auxpass were,stained
R13661 T18020 T18020 ROOT stained,stained
R13662 T18021 T18020 prep with,stained
R13663 T18022 T18023 amod monoclonal,antibodies
R13664 T18023 T18021 pobj antibodies,with
R13665 T18024 T18020 conj directed,stained
R13666 T18025 T18024 prep against,directed
R13667 T18026 T18025 pobj MHC-II,against
R13668 T18027 T18026 punct (,MHC-II
R13669 T18028 T18026 appos I-A/I-E,MHC-II
R13670 T18029 T18026 punct ),MHC-II
R13671 T18030 T18026 conj FITC,MHC-II
R13672 T18031 T18030 punct (,FITC
R13673 T18032 T18030 appos M5/114,FITC
R13674 T18033 T18032 nummod .15.2,M5/114
R13675 T18034 T18030 punct ),FITC
R13676 T18035 T18024 punct ",",directed
R13677 T18036 T18037 compound CD11c,PerCP-Cy5
R13678 T18037 T18038 compound PerCP-Cy5,.5
R13679 T18038 T18040 nummod .5,N418
R13680 T18039 T18040 punct (,N418
R13681 T18040 T18020 npadvmod N418,stained
R13682 T18041 T18040 punct ),N418
R13683 T18042 T18040 punct ",",N418
R13684 T18043 T18044 compound F4/80,APC
R13685 T18044 T18040 appos APC,N418
R13686 T18045 T18046 punct (,BM8
R13687 T18046 T18044 appos BM8,APC
R13688 T18047 T18046 punct ),BM8
R13689 T18048 T18044 punct ",",APC
R13690 T18049 T18050 compound CD62L,PE
R13691 T18050 T18044 appos PE,APC
R13692 T18051 T18052 punct (,MEL-14
R13693 T18052 T18050 appos MEL-14,PE
R13694 T18053 T18050 punct ),PE
R13695 T18054 T18044 punct ",",APC
R13696 T18055 T18057 compound Granzyme,FITC
R13697 T18056 T18057 compound B,FITC
R13698 T18057 T18044 appos FITC,APC
R13699 T18058 T18059 punct (,NGZB
R13700 T18059 T18057 appos NGZB,FITC
R13701 T18060 T18057 punct ),FITC
R13702 T18061 T18057 prep from,FITC
R13703 T18062 T18061 pobj eBiosciences,from
R13704 T18063 T18062 cc and,eBiosciences
R13705 T18064 T18065 compound CD3,Molecular
R13706 T18065 T18062 conj Molecular,eBiosciences
R13707 T18066 T18068 amod Complex,v450
R13708 T18067 T18068 compound Horizon,v450
R13709 T18068 T18065 appos v450,Molecular
R13710 T18069 T18070 punct (,17A2
R13711 T18070 T18068 appos 17A2,v450
R13712 T18071 T18070 punct ),17A2
R13713 T18072 T18065 punct ",",Molecular
R13714 T18073 T18074 compound Ly6C,Horizon
R13715 T18074 T18065 appos Horizon,Molecular
R13716 T18075 T18074 nummod v450,Horizon
R13717 T18076 T18077 punct (,AL-21
R13718 T18077 T18074 appos AL-21,Horizon
R13719 T18078 T18077 punct ),AL-21
R13720 T18079 T18074 punct ",",Horizon
R13721 T18080 T18081 compound Ly6G,PE
R13722 T18081 T18065 appos PE,Molecular
R13723 T18082 T18083 punct (,1A8
R13724 T18083 T18081 appos 1A8,PE
R13725 T18084 T18081 punct ),PE
R13726 T18085 T18065 punct ",",Molecular
R13727 T18086 T18087 compound CD11b,APC-Cy7
R13728 T18087 T18065 appos APC-Cy7,Molecular
R13729 T18088 T18089 punct (,M1/70
R13730 T18089 T18087 appos M1/70,APC-Cy7
R13731 T18090 T18087 punct ),APC-Cy7
R13732 T18091 T18065 punct ",",Molecular
R13733 T18092 T18093 compound CD8α,PerCP
R13734 T18093 T18065 appos PerCP,Molecular
R13735 T18094 T18095 punct (,53-6
R13736 T18095 T18096 nummod 53-6,.7
R13737 T18096 T18093 appos .7,PerCP
R13738 T18097 T18093 punct ),PerCP
R13739 T18098 T18065 punct ",",Molecular
R13740 T18099 T18100 compound IFNγ,Alexa
R13741 T18100 T18065 appos Alexa,Molecular
R13742 T18101 T18100 nummod 647,Alexa
R13743 T18102 T18103 punct (,XMG1
R13744 T18103 T18100 appos XMG1,Alexa
R13745 T18104 T18103 nummod .2,XMG1
R13746 T18105 T18103 punct ),XMG1
R13747 T18106 T18100 cc and,Alexa
R13748 T18107 T18100 conj CD16/32,Alexa
R13749 T18108 T18110 punct (,G2
R13750 T18109 T18110 nummod 2.4,G2
R13751 T18110 T18107 appos G2,CD16/32
R13752 T18111 T18110 punct ),G2
R13753 T18112 T18110 prep from,G2
R13754 T18113 T18114 compound BD,Pharmingen
R13755 T18114 T18112 pobj Pharmingen,from
R13756 T18115 T18040 punct .,N418
R13757 T18116 T18118 nsubjpass Samples,acquired
R13758 T18117 T18118 auxpass were,acquired
R13759 T18118 T18118 ROOT acquired,acquired
R13760 T18119 T18118 prep on,acquired
R13761 T18120 T18122 det a,Cytometer
R13762 T18121 T18122 compound LSRII,Cytometer
R13763 T18122 T18119 pobj Cytometer,on
R13764 T18123 T18118 cc and,acquired
R13765 T18124 T18118 conj analyzed,acquired
R13766 T18125 T18124 xcomp using,analyzed
R13767 T18126 T18127 compound FACSDiva,software
R13768 T18127 T18125 dobj software,using
R13769 T18128 T18127 punct (,software
R13770 T18129 T18130 compound BD,Biosciences
R13771 T18130 T18127 appos Biosciences,software
R13772 T18131 T18127 punct ),software
R13773 T18132 T18118 punct .,acquired
R13774 T18133 T18134 compound Propidium,iodide
R13775 T18134 T18136 nsubjpass iodide,used
R13776 T18135 T18136 auxpass was,used
R13777 T18136 T18136 ROOT used,used
R13778 T18137 T18138 aux to,discriminate
R13779 T18138 T18136 xcomp discriminate,used
R13780 T18139 T18138 prep between,discriminate
R13781 T18140 T18143 amod live,cells
R13782 T18141 T18140 cc and,live
R13783 T18142 T18140 conj dead,live
R13784 T18143 T18139 pobj cells,between
R13785 T18144 T18136 punct .,used
R13894 T18413 T18414 compound Cytokine,quantification
R13895 T18414 T18422 advcl quantification,coated
R13896 T18415 T18414 prep For,quantification
R13897 T18416 T18417 compound TNF,ELISA
R13898 T18417 T18415 pobj ELISA,For
R13899 T18418 T18422 punct ",",coated
R13900 T18419 T18420 amod 96-well,plates
R13901 T18420 T18422 nsubjpass plates,coated
R13902 T18421 T18422 auxpass were,coated
R13903 T18422 T18422 ROOT coated,coated
R13904 T18423 T18422 prep with,coated
R13905 T18424 T18425 compound TNF,coating
R13906 T18425 T18423 pobj coating,with
R13907 T18426 T18425 punct (,coating
R13908 T18427 T18425 appos TN3-19,coating
R13909 T18428 T18425 punct ",",coating
R13910 T18429 T18425 appos eBioscience,coating
R13911 T18430 T18422 punct ),coated
R13912 T18431 T18422 cc and,coated
R13913 T18432 T18422 conj detection,coated
R13914 T18433 T18434 punct (,R4-6A2
R13915 T18434 T18432 appos R4-6A2,detection
R13916 T18435 T18434 punct ",",R4-6A2
R13917 T18436 T18434 appos eBioscience,R4-6A2
R13918 T18437 T18434 punct ),R4-6A2
R13919 T18438 T18432 conj antibodies,detection
R13920 T18439 T18422 punct .,coated
R13921 T18440 T18444 nmod IFNα,levels
R13922 T18441 T18440 cc and,IFNα
R13923 T18442 T18440 conj IFNβ,IFNα
R13924 T18443 T18444 compound protein,levels
R13925 T18444 T18446 nsubjpass levels,determined
R13926 T18445 T18446 auxpass were,determined
R13927 T18446 T18446 ROOT determined,determined
R13928 T18447 T18446 prep with,determined
R13929 T18448 T18450 det an,kit
R13930 T18449 T18450 compound ELISA,kit
R13931 T18450 T18447 pobj kit,with
R13932 T18451 T18450 punct (,kit
R13933 T18452 T18454 compound PBL,Laboratories
R13934 T18453 T18454 compound Biomedical,Laboratories
R13935 T18454 T18450 appos Laboratories,kit
R13936 T18455 T18450 punct ),kit
R13937 T18456 T18446 punct .,determined
R13938 T18457 T18464 prep For,coated
R13939 T18458 T18459 compound IFNγ,ELISA
R13940 T18459 T18457 pobj ELISA,For
R13941 T18460 T18464 punct ",",coated
R13942 T18461 T18462 amod 96-well,plates
R13943 T18462 T18464 nsubjpass plates,coated
R13944 T18463 T18464 auxpass were,coated
R13945 T18464 T18464 ROOT coated,coated
R13946 T18465 T18464 prep with,coated
R13947 T18466 T18467 compound IFNγ,coating
R13948 T18467 T18465 pobj coating,with
R13949 T18468 T18467 punct (,coating
R13950 T18469 T18467 appos XMG1,coating
R13951 T18470 T18469 nummod .2,XMG1
R13952 T18471 T18467 punct ),coating
R13953 T18472 T18467 cc and,coating
R13954 T18473 T18467 conj detection,coating
R13955 T18474 T18473 punct (,detection
R13956 T18475 T18473 appos R4-6A2,detection
R13957 T18476 T18473 punct ),detection
R13958 T18477 T18467 conj antibodies,coating
R13959 T18478 T18477 punct (,antibodies
R13960 T18479 T18477 appos eBiosciences,antibodies
R13961 T18480 T18477 punct ),antibodies
R13962 T18481 T18464 punct .,coated
R13963 T18482 T18497 nsubjpass Detection,performed
R13964 T18483 T18482 prep of,Detection
R13965 T18484 T18483 pobj MCP-1,of
R13966 T18485 T18484 punct ",",MCP-1
R13967 T18486 T18484 conj KC,MCP-1
R13968 T18487 T18486 punct ",",KC
R13969 T18488 T18486 conj TNF,KC
R13970 T18489 T18488 punct ",",TNF
R13971 T18490 T18488 conj IL-1β,TNF
R13972 T18491 T18490 cc and,IL-1β
R13973 T18492 T18490 conj IL-6,IL-1β
R13974 T18493 T18492 prep in,IL-6
R13975 T18494 T18495 compound BAL,fluid
R13976 T18495 T18493 pobj fluid,in
R13977 T18496 T18497 auxpass was,performed
R13978 T18497 T18497 ROOT performed,performed
R13979 T18498 T18497 advcl using,performed
R13980 T18499 T18498 dobj Bioplex,using
R13981 T18500 T18499 punct (,Bioplex
R13982 T18501 T18499 appos BioRad,Bioplex
R13983 T18502 T18499 punct ),Bioplex
R13984 T18503 T18498 conj technology,using
R13985 T18504 T18497 prep according,performed
R13986 T18505 T18504 prep to,according
R13987 T18506 T18507 det the,manufacturer
R13988 T18507 T18509 poss manufacturer,instructions
R13989 T18508 T18507 case 's,manufacturer
R13990 T18509 T18505 pobj instructions,to
R13991 T18510 T18497 punct .,performed
R13992 T18511 T18512 compound Milliplex,technology
R13993 T18512 T18517 nsubjpass technology,used
R13994 T18513 T18514 punct (,Millipore
R13995 T18514 T18512 appos Millipore,technology
R13996 T18515 T18512 punct ),technology
R13997 T18516 T18517 auxpass was,used
R13998 T18517 T18517 ROOT used,used
R13999 T18518 T18517 prep for,used
R14000 T18519 T18520 det the,detection
R14001 T18520 T18518 pobj detection,for
R14002 T18521 T18520 prep of,detection
R14003 T18522 T18521 pobj MIP-2,of
R14004 T18523 T18520 prep in,detection
R14005 T18524 T18525 compound BAL,fluid
R14006 T18525 T18523 pobj fluid,in
R14007 T18526 T18517 punct .,used
R14148 T18831 T18832 compound RNA,isolation
R14149 T18832 T18841 nsubjpass isolation,extracted
R14150 T18833 T18832 punct ",",isolation
R14151 T18834 T18835 compound cDNA,synthesis
R14152 T18835 T18832 conj synthesis,isolation
R14153 T18836 T18835 cc and,synthesis
R14154 T18837 T18839 compound qPCR,RNA
R14155 T18838 T18839 compound Total,RNA
R14156 T18839 T18832 appos RNA,isolation
R14157 T18840 T18841 auxpass was,extracted
R14158 T18841 T18841 ROOT extracted,extracted
R14159 T18842 T18841 advcl using,extracted
R14160 T18843 T18847 compound Aurum,kit
R14161 T18844 T18845 compound Total,RNA
R14162 T18845 T18846 compound RNA,mini
R14163 T18846 T18847 compound mini,kit
R14164 T18847 T18842 dobj kit,using
R14165 T18848 T18847 punct (,kit
R14166 T18849 T18847 appos BioRad,kit
R14167 T18850 T18849 punct ),BioRad
R14168 T18851 T18841 cc and,extracted
R14169 T18852 T18853 nsubj reverse,transcribed
R14170 T18853 T18841 conj transcribed,extracted
R14171 T18854 T18853 prep into,transcribed
R14172 T18855 T18854 pobj cDNA,into
R14173 T18856 T18853 prep with,transcribed
R14174 T18857 T18858 compound iScript,cDNA
R14175 T18858 T18860 compound cDNA,kit
R14176 T18859 T18860 compound synthesis,kit
R14177 T18860 T18856 pobj kit,with
R14178 T18861 T18860 punct (,kit
R14179 T18862 T18860 appos BioRad,kit
R14180 T18863 T18860 punct ),kit
R14181 T18864 T18853 prep according,transcribed
R14182 T18865 T18864 prep to,according
R14183 T18866 T18867 det the,manufacturer
R14184 T18867 T18869 poss manufacturer,instructions
R14185 T18868 T18867 case 's,manufacturer
R14186 T18869 T18865 pobj instructions,to
R14187 T18870 T18853 punct .,transcribed
R14188 T18871 T18873 nsubjpass qPCR,performed
R14189 T18872 T18873 auxpass was,performed
R14190 T18873 T18873 ROOT performed,performed
R14191 T18874 T18873 prep by,performed
R14192 T18875 T18874 pcomp using,by
R14193 T18876 T18877 compound SYBR,Green
R14194 T18877 T18875 dobj Green,using
R14195 T18878 T18879 nsubj I,master
R14196 T18879 T18880 compound master,mix
R14197 T18880 T18873 npadvmod mix,performed
R14198 T18881 T18880 nummod I,mix
R14199 T18882 T18881 punct (,I
R14200 T18883 T18881 appos Roche,I
R14201 T18884 T18881 punct ),I
R14202 T18885 T18881 prep in,I
R14203 T18886 T18890 det the,system
R14204 T18887 T18890 nmod Lightcycler,system
R14205 T18888 T18890 nummod 480,system
R14206 T18889 T18890 compound detection,system
R14207 T18890 T18885 pobj system,in
R14208 T18891 T18890 punct (,system
R14209 T18892 T18890 appos Roche,system
R14210 T18893 T18890 punct ),system
R14211 T18894 T18873 prep with,performed
R14212 T18895 T18897 det the,primers
R14213 T18896 T18897 amod following,primers
R14214 T18897 T18894 pobj primers,with
R14215 T18898 T18873 punct :,performed
R14216 T18899 T18899 ROOT HPRT,HPRT
R14217 T18900 T18899 punct :,HPRT
R14218 T18901 T18905 nummod 5,′
R14219 T18902 T18904 punct ′,AGTGTTGGATACAGGCCAGAC-3
R14220 T18903 T18904 punct -,AGTGTTGGATACAGGCCAGAC-3
R14221 T18904 T18905 compound AGTGTTGGATACAGGCCAGAC-3,′
R14222 T18905 T18899 appos ′,HPRT
R14223 T18906 T18905 cc and,′
R14224 T18907 T18908 nummod 5,′
R14225 T18908 T18910 nummod ′,′
R14226 T18909 T18910 amod CGTGATTCAAATCCCTGAAGT-3,′
R14227 T18910 T18905 conj ′,′
R14228 T18911 T18899 punct ;,HPRT
R14229 T18912 T18899 conj IL-6,HPRT
R14230 T18913 T18912 punct :,IL-6
R14231 T18914 T18918 nummod 5,′
R14232 T18915 T18917 punct ′,GAGGATACCACTCCCAACAGACC-3
R14233 T18916 T18917 punct -,GAGGATACCACTCCCAACAGACC-3
R14234 T18917 T18918 compound GAGGATACCACTCCCAACAGACC-3,′
R14235 T18918 T18912 appos ′,IL-6
R14236 T18919 T18918 cc and,′
R14237 T18920 T18923 nummod 5,AAGTGCATCATCGTTGTTCATACA-3
R14238 T18921 T18923 punct ′,AAGTGCATCATCGTTGTTCATACA-3
R14239 T18922 T18923 punct -,AAGTGCATCATCGTTGTTCATACA-3
R14240 T18923 T18924 compound AAGTGCATCATCGTTGTTCATACA-3,′
R14241 T18924 T18918 conj ′,′
R14242 T18925 T18926 punct ;,IFNβ
R14243 T18926 T18912 conj IFNβ,IL-6
R14244 T18927 T18926 punct :,IFNβ
R14245 T18928 T18932 nummod 5,′
R14246 T18929 T18931 punct ′,TCAGAATGAGTGGTGGTTGC-3
R14247 T18930 T18931 punct -,TCAGAATGAGTGGTGGTTGC-3
R14248 T18931 T18932 compound TCAGAATGAGTGGTGGTTGC-3,′
R14249 T18932 T18926 appos ′,IFNβ
R14250 T18933 T18932 cc and,′
R14251 T18934 T18937 nummod 5,GACCTTTCAAATGCAGTAGATTCA-3
R14252 T18935 T18937 punct ′,GACCTTTCAAATGCAGTAGATTCA-3
R14253 T18936 T18937 punct -,GACCTTTCAAATGCAGTAGATTCA-3
R14254 T18937 T18938 compound GACCTTTCAAATGCAGTAGATTCA-3,′
R14255 T18938 T18932 conj ′,′
R14256 T18939 T18926 punct ;,IFNβ
R14257 T18940 T18926 conj A20,IFNβ
R14258 T18941 T18940 punct :,A20
R14259 T18942 T18946 nummod 5,′
R14260 T18943 T18945 punct ′,AAACCAATGGTGATGGAAACTG-3
R14261 T18944 T18945 punct -,AAACCAATGGTGATGGAAACTG-3
R14262 T18945 T18946 compound AAACCAATGGTGATGGAAACTG-3,′
R14263 T18946 T18940 appos ′,A20
R14264 T18947 T18946 cc and,′
R14265 T18948 T18951 nummod 5,GTTGTCCCATTCGTCATTCC-3
R14266 T18949 T18951 punct ′,GTTGTCCCATTCGTCATTCC-3
R14267 T18950 T18951 punct -,GTTGTCCCATTCGTCATTCC-3
R14268 T18951 T18952 compound GTTGTCCCATTCGTCATTCC-3,′
R14269 T18952 T18946 conj ′,′
R14270 T18953 T18954 punct ;,CCL2
R14271 T18954 T18940 conj CCL2,A20
R14272 T18955 T18954 punct :,CCL2
R14273 T18956 T18960 nummod 5,′
R14274 T18957 T18959 punct ′,TTAAAAACCTGGATCGGAACCAA-3
R14275 T18958 T18959 punct -,TTAAAAACCTGGATCGGAACCAA-3
R14276 T18959 T18960 compound TTAAAAACCTGGATCGGAACCAA-3,′
R14277 T18960 T18954 appos ′,CCL2
R14278 T18961 T18960 cc and,′
R14279 T18962 T18965 nummod 5,GCATTAGCTTCAGATTTACGGGT-3
R14280 T18963 T18965 punct ′,GCATTAGCTTCAGATTTACGGGT-3
R14281 T18964 T18965 punct -,GCATTAGCTTCAGATTTACGGGT-3
R14282 T18965 T18966 compound GCATTAGCTTCAGATTTACGGGT-3,′
R14283 T18966 T18960 conj ′,′
R14284 T18967 T18954 punct ;,CCL2
R14285 T18968 T18954 conj CXCL1,CCL2
R14286 T18969 T18968 punct :,CXCL1
R14287 T18970 T18974 nummod 5,′
R14288 T18971 T18973 punct ′,GAGCCTCTAACCAGTTCCAG-3
R14289 T18972 T18973 punct -,GAGCCTCTAACCAGTTCCAG-3
R14290 T18973 T18974 compound GAGCCTCTAACCAGTTCCAG-3,′
R14291 T18974 T18968 appos ′,CXCL1
R14292 T18975 T18974 cc and,′
R14293 T18976 T18979 nummod 5,TGAGTGTGGCTATGACTTCG-3
R14294 T18977 T18979 punct ′,TGAGTGTGGCTATGACTTCG-3
R14295 T18978 T18979 punct -,TGAGTGTGGCTATGACTTCG-3
R14296 T18979 T18980 compound TGAGTGTGGCTATGACTTCG-3,′
R14297 T18980 T18974 conj ′,′
R14298 T18981 T18980 cc and,′
R14299 T18982 T18980 conj IFNα4,′
R14300 T18983 T18982 punct :,IFNα4
R14301 T18984 T18988 nummod 5,′
R14302 T18985 T18987 punct ′,TGATGAGCTACTACTGGTCAGC-3
R14303 T18986 T18987 punct -,TGATGAGCTACTACTGGTCAGC-3
R14304 T18987 T18988 compound TGATGAGCTACTACTGGTCAGC-3,′
R14305 T18988 T18982 appos ′,IFNα4
R14306 T18989 T18988 cc and,′
R14307 T18990 T18993 nummod 5,GATCTCTTAGCACAAGGATGGC-3
R14308 T18991 T18993 punct ′,GATCTCTTAGCACAAGGATGGC-3
R14309 T18992 T18993 punct -,GATCTCTTAGCACAAGGATGGC-3
R14310 T18993 T18994 compound GATCTCTTAGCACAAGGATGGC-3,′
R14311 T18994 T18988 conj ′,′
R14312 T18995 T18899 punct .,HPRT
R14313 T18996 T18998 nsubjpass Primers,designed
R14314 T18997 T18998 auxpass were,designed
R14315 T18998 T18998 ROOT designed,designed
R14316 T18999 T18998 prep with,designed
R14317 T19000 T18999 pobj PerlPrimer,with
R14318 T19001 T19000 punct (,PerlPrimer
R14319 T19002 T19000 appos http://perlprimer.sourceforge.net,PerlPrimer
R14320 T19003 T19000 punct ),PerlPrimer
R14321 T19004 T18998 punct .,designed
R14322 T19005 T19007 nsubjpass Quantification,performed
R14323 T19006 T19007 auxpass was,performed
R14324 T19007 T19007 ROOT performed,performed
R14325 T19008 T19007 advcl using,performed
R14326 T19009 T19012 det the,method
R14327 T19010 T19012 amod comparative,method
R14328 T19011 T19012 compound CT,method
R14329 T19012 T19008 dobj method,using
R14330 T19013 T19014 punct (,ΔΔCT
R14331 T19014 T19012 appos ΔΔCT,method
R14332 T19015 T19014 punct ),ΔΔCT
R14333 T19016 T19007 punct .,performed
R14334 T19017 T19019 nsubjpass Results,expressed
R14335 T19018 T19019 auxpass are,expressed
R14336 T19019 T19019 ROOT expressed,expressed
R14337 T19020 T19019 oprd relative,expressed
R14338 T19021 T19020 prep to,relative
R14339 T19022 T19023 compound HPRT,values
R14340 T19023 T19021 pobj values,to
R14341 T19024 T19019 punct .,expressed
R14419 T19178 T19179 compound Statistics,Results
R14420 T19179 T19181 nsubjpass Results,expressed
R14421 T19180 T19181 auxpass are,expressed
R14422 T19181 T19181 ROOT expressed,expressed
R14423 T19182 T19181 prep as,expressed
R14424 T19183 T19186 det the,SEM
R14425 T19184 T19186 amod mean,SEM
R14426 T19185 T19186 compound ±,SEM
R14427 T19186 T19182 pobj SEM,as
R14428 T19187 T19181 punct .,expressed
R14429 T19188 T19189 compound Statistical,significance
R14430 T19189 T19193 nsubjpass significance,assessed
R14431 T19190 T19189 prep between,significance
R14432 T19191 T19190 pobj groups,between
R14433 T19192 T19193 auxpass was,assessed
R14434 T19193 T19193 ROOT assessed,assessed
R14435 T19194 T19193 advcl using,assessed
R14436 T19195 T19196 amod two-way,ANOVA
R14437 T19196 T19194 dobj ANOVA,using
R14438 T19197 T19193 punct .,assessed
R14439 T19198 T19199 det The,differences
R14440 T19199 T19213 nsubjpass differences,calculated
R14441 T19200 T19199 prep for,differences
R14442 T19201 T19203 nmod in,experiments
R14443 T19202 T19203 compound vivo,experiments
R14444 T19203 T19200 pobj experiments,for
R14445 T19204 T19203 punct (,experiments
R14446 T19205 T19206 advmod at,least
R14447 T19206 T19207 advmod least,5
R14448 T19207 T19208 nummod 5,mice
R14449 T19208 T19203 appos mice,experiments
R14450 T19209 T19208 prep per,mice
R14451 T19210 T19209 pobj group,per
R14452 T19211 T19203 punct ),experiments
R14453 T19212 T19213 auxpass were,calculated
R14454 T19213 T19213 ROOT calculated,calculated
R14455 T19214 T19213 advcl using,calculated
R14456 T19215 T19217 det the,U-test
R14457 T19216 T19217 compound Mann-Whitney,U-test
R14458 T19217 T19214 dobj U-test,using
R14459 T19218 T19214 prep for,using
R14460 T19219 T19220 amod unpaired,data
R14461 T19220 T19218 pobj data,for
R14462 T19221 T19213 punct .,calculated
R14463 T19222 T19223 compound Statistical,significance
R14464 T19223 T19230 nsubjpass significance,analyzed
R14465 T19224 T19223 prep of,significance
R14466 T19225 T19224 pobj differences,of
R14467 T19226 T19225 prep between,differences
R14468 T19227 T19228 compound survival,rates
R14469 T19228 T19226 pobj rates,between
R14470 T19229 T19230 auxpass was,analyzed
R14471 T19230 T19230 ROOT analyzed,analyzed
R14472 T19231 T19230 prep by,analyzed
R14473 T19232 T19231 pcomp comparing,by
R14474 T19233 T19234 compound Kaplan-Meier,curves
R14475 T19234 T19232 dobj curves,comparing
R14476 T19235 T19234 acl using,curves
R14477 T19236 T19238 det the,test
R14478 T19237 T19238 compound log-rank,test
R14479 T19238 T19235 dobj test,using
R14480 T19239 T19238 punct (,test
R14481 T19240 T19242 compound GraphPad,version
R14482 T19241 T19242 compound Prism,version
R14483 T19242 T19238 appos version,test
R14484 T19243 T19242 nummod 5,version
R14485 T19244 T19242 punct ",",version
R14486 T19245 T19242 appos GraphPad,version
R14487 T19246 T19245 punct ",",GraphPad
R14488 T19247 T19248 compound San,Diego
R14489 T19248 T19245 conj Diego,GraphPad
R14490 T19249 T19248 punct ",",Diego
R14491 T19250 T19248 conj CA,Diego
R14492 T19251 T19238 punct ),test
R14493 T19252 T19230 punct .,analyzed
R14785 T19712 T19713 nummod A20,inhibits
R14786 T19713 T19714 nsubj inhibits,NF-κB
R14787 T19714 T19717 amod NF-κB,activation
R14788 T19715 T19714 cc and,NF-κB
R14789 T19716 T19714 conj IRF3,NF-κB
R14790 T19717 T19717 ROOT activation,activation
R14791 T19718 T19717 prep in,activation
R14792 T19719 T19718 pobj response,in
R14793 T19720 T19719 prep to,response
R14794 T19721 T19722 compound RIG-I,stimulation
R14795 T19722 T19720 pobj stimulation,to
R14796 T19723 T19717 punct .,activation
R14797 T19724 T19725 punct (,A
R14798 T19725 T19725 ROOT A,A
R14799 T19726 T19725 punct ),A
R14800 T19727 T19728 nummod HEK293T,cells
R14801 T19728 T19730 nsubjpass cells,transfected
R14802 T19729 T19730 auxpass were,transfected
R14803 T19730 T19730 ROOT transfected,transfected
R14804 T19731 T19730 prep with,transfected
R14805 T19732 T19731 pobj NF-κB,with
R14806 T19733 T19734 punct (,left
R14807 T19734 T19732 parataxis left,NF-κB
R14808 T19735 T19734 punct ),left
R14809 T19736 T19732 punct ",",NF-κB
R14810 T19737 T19732 conj IRF3,NF-κB
R14811 T19738 T19739 punct (,middle
R14812 T19739 T19737 parataxis middle,IRF3
R14813 T19740 T19739 punct ),middle
R14814 T19741 T19737 cc or,IRF3
R14815 T19742 T19737 conj IRF7,IRF3
R14816 T19743 T19745 amod dependent,reporter
R14817 T19744 T19745 compound luciferase,reporter
R14818 T19745 T19732 appos reporter,NF-κB
R14819 T19746 T19747 punct (,right
R14820 T19747 T19732 appos right,NF-κB
R14821 T19748 T19732 punct ),NF-κB
R14822 T19749 T19731 pobj plasmids,with
R14823 T19750 T19730 punct ",",transfected
R14824 T19751 T19752 advmod together,with
R14825 T19752 T19730 prep with,transfected
R14826 T19753 T19752 pobj plasmids,with
R14827 T19754 T19753 acl expressing,plasmids
R14828 T19755 T19754 dobj RIG-I,expressing
R14829 T19756 T19755 punct (,RIG-I
R14830 T19757 T19755 appos 2CARD,RIG-I
R14831 T19758 T19755 punct ),RIG-I
R14832 T19759 T19755 punct ",",RIG-I
R14833 T19760 T19755 conj IRF7,RIG-I
R14834 T19761 T19762 punct (,right
R14835 T19762 T19760 parataxis right,IRF7
R14836 T19763 T19762 punct ),right
R14837 T19764 T19754 cc and,expressing
R14838 T19765 T19754 conj increasing,expressing
R14839 T19766 T19765 dobj amounts,increasing
R14840 T19767 T19766 prep of,amounts
R14841 T19768 T19767 pobj A20,of
R14842 T19769 T19730 punct .,transfected
R14843 T19770 T19771 amod Luciferase,activity
R14844 T19771 T19776 nsubjpass activity,analyzed
R14845 T19772 T19771 prep in,activity
R14846 T19773 T19774 compound cell,extracts
R14847 T19774 T19772 pobj extracts,in
R14848 T19775 T19776 auxpass was,analyzed
R14849 T19776 T19776 ROOT analyzed,analyzed
R14850 T19777 T19776 prep in,analyzed
R14851 T19778 T19779 det a,luminometer
R14852 T19779 T19777 pobj luminometer,in
R14853 T19780 T19776 punct .,analyzed
R14854 T19781 T19782 nsubj Numbers,are
R14855 T19782 T19782 ROOT are,are
R14856 T19783 T19782 attr averages,are
R14857 T19784 T19782 conj +,are
R14858 T19785 T19787 nummod /,SD
R14859 T19786 T19787 compound −,SD
R14860 T19787 T19782 npadvmod SD,are
R14861 T19788 T19787 prep of,SD
R14862 T19789 T19790 nummod 3,samples
R14863 T19790 T19788 pobj samples,of
R14864 T19791 T19790 prep per,samples
R14865 T19792 T19791 pobj set-up,per
R14866 T19793 T19782 punct .,are
R14867 T19794 T19805 punct (,BMDM
R14868 T19795 T19805 nmod B,BMDM
R14869 T19796 T19795 appos D,B
R14870 T19797 T19795 punct ),B
R14871 T19798 T19795 conj A20myel-KO,B
R14872 T19799 T19798 cc and,A20myel-KO
R14873 T19800 T19801 amod wild,type
R14874 T19801 T19798 conj type,A20myel-KO
R14875 T19802 T19803 punct (,A20myel-WT
R14876 T19803 T19801 appos A20myel-WT,type
R14877 T19804 T19805 punct ),BMDM
R14878 T19805 T19807 nsubjpass BMDM,transfected
R14879 T19806 T19807 auxpass were,transfected
R14880 T19807 T19807 ROOT transfected,transfected
R14881 T19808 T19807 prep with,transfected
R14882 T19809 T19810 compound LMW,poly
R14883 T19810 T19808 pobj poly,with
R14884 T19811 T19814 punct (,C
R14885 T19812 T19814 nsubj I,C
R14886 T19813 T19814 punct :,C
R14887 T19814 T19807 parataxis C,transfected
R14888 T19815 T19814 punct ),C
R14889 T19816 T19807 cc and,transfected
R14890 T19817 T19807 conj analyzed,transfected
R14891 T19818 T19817 prep at,analyzed
R14892 T19819 T19821 amod different,points
R14893 T19820 T19821 compound time,points
R14894 T19821 T19818 pobj points,at
R14895 T19822 T19823 punct (,minutes
R14896 T19823 T19821 appos minutes,points
R14897 T19824 T19817 punct ),analyzed
R14898 T19825 T19817 prep after,analyzed
R14899 T19826 T19827 det the,start
R14900 T19827 T19825 pobj start,after
R14901 T19828 T19827 prep of,start
R14902 T19829 T19828 pobj transfection,of
R14903 T19830 T19827 prep for,start
R14904 T19831 T19832 compound IκBα,phosphorylation
R14905 T19832 T19830 pobj phosphorylation,for
R14906 T19833 T19832 cc and,phosphorylation
R14907 T19834 T19832 conj degradation,phosphorylation
R14908 T19835 T19834 punct ",",degradation
R14909 T19836 T19832 cc and,phosphorylation
R14910 T19837 T19838 compound IRF3,phosphorylation
R14911 T19838 T19838 ROOT phosphorylation,phosphorylation
R14912 T19839 T19838 prep by,phosphorylation
R14913 T19840 T19839 pcomp immunoblotting,by
R14914 T19841 T19840 prep of,immunoblotting
R14915 T19842 T19844 amod total,extracts
R14916 T19843 T19844 compound cell,extracts
R14917 T19844 T19841 pobj extracts,of
R14918 T19845 T19846 punct (,B
R14919 T19846 T19844 appos B,extracts
R14920 T19847 T19844 punct ),extracts
R14921 T19848 T19807 punct .,transfected
R14922 T19849 T19850 det The,band
R14923 T19850 T19867 nsubjpass band,used
R14924 T19851 T19854 nsubjpass that,recognized
R14925 T19852 T19854 auxpass is,recognized
R14926 T19853 T19854 advmod non-specifically,recognized
R14927 T19854 T19850 relcl recognized,band
R14928 T19855 T19854 agent by,recognized
R14929 T19856 T19858 det the,antibody
R14930 T19857 T19858 amod anti-IκBα,antibody
R14931 T19858 T19855 pobj antibody,by
R14932 T19859 T19860 punct (,indicated
R14933 T19860 T19858 acl indicated,antibody
R14934 T19861 T19860 agent by,indicated
R14935 T19862 T19863 det an,asterisk
R14936 T19863 T19861 pobj asterisk,by
R14937 T19864 T19850 punct ),band
R14938 T19865 T19867 aux can,used
R14939 T19866 T19867 auxpass be,used
R14940 T19867 T19867 ROOT used,used
R14941 T19868 T19867 prep as,used
R14942 T19869 T19871 det a,control
R14943 T19870 T19871 compound loading,control
R14944 T19871 T19868 pobj control,as
R14945 T19872 T19867 punct .,used
R14946 T19873 T19874 compound Nuclear,translocation
R14947 T19874 T19883 nsubjpass translocation,analyzed
R14948 T19875 T19874 prep of,translocation
R14949 T19876 T19875 pobj NF-κB,of
R14950 T19877 T19878 punct (,p65
R14951 T19878 T19876 appos p65,NF-κB
R14952 T19879 T19878 punct ),p65
R14953 T19880 T19876 cc and,NF-κB
R14954 T19881 T19876 conj IRF3,NF-κB
R14955 T19882 T19883 auxpass was,analyzed
R14956 T19883 T19883 ROOT analyzed,analyzed
R14957 T19884 T19883 agent by,analyzed
R14958 T19885 T19884 pobj immunoblotting,by
R14959 T19886 T19885 prep of,immunoblotting
R14960 T19887 T19890 amod cytoplasmic,fractions
R14961 T19888 T19887 cc or,cytoplasmic
R14962 T19889 T19887 conj nuclear,cytoplasmic
R14963 T19890 T19886 pobj fractions,of
R14964 T19891 T19892 punct (,C
R14965 T19892 T19890 appos C,fractions
R14966 T19893 T19883 punct ),analyzed
R14967 T19894 T19883 punct .,analyzed
R14968 T19895 T19905 nsubjpass Quantification,shown
R14969 T19896 T19895 prep of,Quantification
R14970 T19897 T19898 compound band,density
R14971 T19898 T19896 pobj density,of
R14972 T19899 T19895 prep for,Quantification
R14973 T19900 T19901 amod nuclear,p65
R14974 T19901 T19899 pobj p65,for
R14975 T19902 T19901 cc and,p65
R14976 T19903 T19905 nsubjpass IRF3,shown
R14977 T19904 T19905 auxpass is,shown
R14978 T19905 T19921 ccomp shown,time
R14979 T19906 T19905 prep in,shown
R14980 T19907 T19908 compound bar,graphs
R14981 T19908 T19906 pobj graphs,in
R14982 T19909 T19905 punct (,shown
R14983 T19910 T19910 ROOT expressed,expressed
R14984 T19911 T19910 prep as,expressed
R14985 T19912 T19913 amod relative,density
R14986 T19913 T19911 pobj density,as
R14987 T19914 T19905 prep compared,shown
R14988 T19915 T19914 prep to,compared
R14989 T19916 T19918 det the,lane
R14990 T19917 T19918 amod first,lane
R14991 T19918 T19915 pobj lane,to
R14992 T19919 T19921 punct ;,time
R14993 T19920 T19921 punct =,time
R14994 T19921 T19921 ROOT time,time
R14995 T19922 T19921 nummod 0,time
R14996 T19923 T19921 punct ),time
R14997 T19924 T19921 punct .,time
R14998 T19925 T19930 nmod IL-6,levels
R14999 T19926 T19925 punct ",",IL-6
R15000 T19927 T19925 conj TNF,IL-6
R15001 T19928 T19927 cc and,TNF
R15002 T19929 T19927 conj IFNβ,TNF
R15003 T19930 T19942 nsubjpass levels,determined
R15004 T19931 T19930 prep in,levels
R15005 T19932 T19933 det the,supernatant
R15006 T19933 T19931 pobj supernatant,in
R15007 T19934 T19933 prep of,supernatant
R15008 T19935 T19934 pobj cells,of
R15009 T19936 T19935 acl used,cells
R15010 T19937 T19936 prep in,used
R15011 T19938 T19939 punct (,B
R15012 T19939 T19937 pobj B,in
R15013 T19940 T19930 punct ),levels
R15014 T19941 T19942 auxpass were,determined
R15015 T19942 T19942 ROOT determined,determined
R15016 T19943 T19942 agent by,determined
R15017 T19944 T19943 pobj bioassay,by
R15018 T19945 T19946 punct (,IL-6
R15019 T19946 T19944 appos IL-6,bioassay
R15020 T19947 T19946 punct ),IL-6
R15021 T19948 T19944 cc and,bioassay
R15022 T19949 T19944 conj ELISA,bioassay
R15023 T19950 T19951 punct (,TNF
R15024 T19951 T19949 appos TNF,ELISA
R15025 T19952 T19951 cc and,TNF
R15026 T19953 T19951 conj IFNβ,TNF
R15027 T19954 T19949 punct ),ELISA
R15028 T19955 T19956 mark as,described
R15029 T19956 T19942 advcl described,determined
R15030 T19957 T19956 prep in,described
R15031 T19958 T19959 det the,materials
R15032 T19959 T19957 pobj materials,in
R15033 T19960 T19959 cc and,materials
R15034 T19961 T19959 conj methods,materials
R15035 T19962 T19956 npadvmod section,described
R15036 T19963 T19964 punct (,D
R15037 T19964 T19962 appos D,section
R15038 T19965 T19962 punct ),section
R15039 T19966 T19942 punct .,determined
R15040 T19967 T19968 nsubj Data,are
R15041 T19968 T19968 ROOT are,are
R15042 T19969 T19968 attr representative,are
R15043 T19970 T19969 prep of,representative
R15044 T19971 T19973 nummod 2,experiments
R15045 T19972 T19973 amod independent,experiments
R15046 T19973 T19970 pobj experiments,of
R15047 T19974 T19968 punct .,are
R15304 T20475 T20477 nsubj A20,regulates
R15305 T20476 T20477 advmod negatively,regulates
R15306 T20477 T20477 ROOT regulates,regulates
R15307 T20478 T20480 amod IAV-induced,expression
R15308 T20479 T20480 compound gene,expression
R15309 T20480 T20477 dobj expression,regulates
R15310 T20481 T20480 prep in,expression
R15311 T20482 T20481 pobj BMDM,in
R15312 T20483 T20482 cc and,BMDM
R15313 T20484 T20485 amod alveolar,macrophages
R15314 T20485 T20482 conj macrophages,BMDM
R15315 T20486 T20477 punct .,regulates
R15316 T20487 T20492 punct (,isolated
R15317 T20488 T20492 dobj A,isolated
R15318 T20489 T20491 compound B,BMDM
R15319 T20490 T20491 punct ),BMDM
R15320 T20491 T20492 nsubj BMDM,isolated
R15321 T20492 T20492 ROOT isolated,isolated
R15322 T20493 T20492 prep from,isolated
R15323 T20494 T20497 amod A20myel-WT,animals
R15324 T20495 T20494 cc and,A20myel-WT
R15325 T20496 T20494 conj A20myel-KO,A20myel-WT
R15326 T20497 T20493 pobj animals,from
R15327 T20498 T20499 auxpass were,infected
R15328 T20499 T20492 dep infected,isolated
R15329 T20500 T20499 prep with,infected
R15330 T20501 T20500 pobj IAV,with
R15331 T20502 T20501 punct (,IAV
R15332 T20503 T20501 nmod moi,IAV
R15333 T20504 T20503 nummod 1,moi
R15334 T20505 T20504 punct ),1
R15335 T20506 T20492 punct .,isolated
R15336 T20507 T20518 prep At,lysed
R15337 T20508 T20509 amod different,hours
R15338 T20509 T20510 compound hours,post
R15339 T20510 T20511 compound post,infection
R15340 T20511 T20507 pobj infection,At
R15341 T20512 T20514 punct (,p.i.
R15342 T20513 T20514 compound hours,p.i.
R15343 T20514 T20511 appos p.i.,infection
R15344 T20515 T20514 punct ),p.i.
R15345 T20516 T20518 nsubjpass cells,lysed
R15346 T20517 T20518 auxpass were,lysed
R15347 T20518 T20518 ROOT lysed,lysed
R15348 T20519 T20518 cc and,lysed
R15349 T20520 T20518 conj IL-6,lysed
R15350 T20521 T20520 punct ",",IL-6
R15351 T20522 T20520 conj IFNβ,IL-6
R15352 T20523 T20522 cc and,IFNβ
R15353 T20524 T20525 compound A20,mRNA
R15354 T20525 T20526 compound mRNA,expression
R15355 T20526 T20522 conj expression,IFNβ
R15356 T20527 T20528 auxpass was,analyzed
R15357 T20528 T20518 conj analyzed,lysed
R15358 T20529 T20528 agent by,analyzed
R15359 T20530 T20529 pobj qPCR,by
R15360 T20531 T20532 punct (,A
R15361 T20532 T20530 appos A,qPCR
R15362 T20533 T20530 punct ),qPCR
R15363 T20534 T20518 punct .,lysed
R15364 T20535 T20536 nummod 18,hours
R15365 T20536 T20537 nsubj hours,post
R15366 T20537 T20537 ROOT post,post
R15367 T20538 T20540 compound infection,culture
R15368 T20539 T20540 compound cell,culture
R15369 T20540 T20537 dobj culture,post
R15370 T20541 T20543 nsubjpass supernatant,analyzed
R15371 T20542 T20543 auxpass was,analyzed
R15372 T20543 T20537 relcl analyzed,post
R15373 T20544 T20543 prep for,analyzed
R15374 T20545 T20549 nmod TNF,levels
R15375 T20546 T20545 cc and,TNF
R15376 T20547 T20545 conj IFNβ,TNF
R15377 T20548 T20549 compound protein,levels
R15378 T20549 T20544 pobj levels,for
R15379 T20550 T20543 agent by,analyzed
R15380 T20551 T20550 pobj ELISA,by
R15381 T20552 T20543 cc and,analyzed
R15382 T20553 T20554 compound multiplexing,technologies
R15383 T20554 T20537 advcl technologies,post
R15384 T20555 T20556 punct (,B
R15385 T20556 T20554 appos B,technologies
R15386 T20557 T20554 punct ),technologies
R15387 T20558 T20537 punct .,post
R15388 T20559 T20561 punct (,D
R15389 T20560 T20561 meta C,D
R15390 T20561 T20561 ROOT D,D
R15391 T20562 T20561 punct ),D
R15392 T20563 T20564 compound Alveolar,macrophages
R15393 T20564 T20565 nsubj macrophages,were
R15394 T20565 T20567 auxpass were,treated
R15395 T20566 T20567 amod mock,treated
R15412 T20583 T20584 compound mRNA,expression
R15413 T20584 T20580 conj expression,IL-6
R15414 T20585 T20586 auxpass was,determined
R15415 T20586 T20586 ROOT determined,determined
R15416 T20587 T20586 agent by,determined
R15417 T20588 T20587 pobj qPCR,by
R15418 T20589 T20588 punct (,qPCR
R15419 T20590 T20588 appos C,qPCR
R15420 T20591 T20588 punct ),qPCR
R15421 T20592 T20586 punct .,determined
R15422 T20593 T20594 compound Cell,culture
R15423 T20594 T20595 compound culture,supernatant
R15424 T20595 T20597 nsubjpass supernatant,analyzed
R15425 T20596 T20597 auxpass was,analyzed
R15426 T20597 T20597 ROOT analyzed,analyzed
R15427 T20598 T20597 prep for,analyzed
R15428 T20599 T20603 nmod IL-6,levels
R15429 T20600 T20599 cc and,IL-6
R15430 T20601 T20599 conj IFNβ,IL-6
R15431 T20602 T20603 compound protein,levels
R15432 T20603 T20598 pobj levels,for
R15433 T20604 T20597 agent by,analyzed
R15434 T20605 T20604 pobj ELISA,by
R15435 T20606 T20597 cc and,analyzed
R15436 T20607 T20608 compound multiplexing,technologies
R15437 T20608 T20597 conj technologies,analyzed
R15438 T20609 T20610 punct (,D
R15439 T20610 T20608 appos D,technologies
R15440 T20611 T20608 punct ),technologies
R15441 T20612 T20597 punct .,analyzed
R15442 T20613 T20614 compound Error,bars
R15443 T20614 T20615 nsubj bars,represent
R15444 T20615 T20615 ROOT represent,represent
R15445 T20616 T20617 amod mean,values
R15446 T20617 T20615 dobj values,represent
R15447 T20618 T20617 punct (,values
R15448 T20619 T20622 advmod +,SEM
R15449 T20620 T20622 compound /,SEM
R15450 T20621 T20622 compound −,SEM
R15451 T20622 T20617 appos SEM,values
R15452 T20623 T20617 punct ),values
R15453 T20624 T20617 prep of,values
R15454 T20625 T20624 pobj 2,of
R15455 T20626 T20627 nummod 3,samples
R15456 T20627 T20617 appos samples,values
R15457 T20628 T20615 punct .,represent
R15458 T20629 T20630 nsubj Results,are
R15459 T20630 T20630 ROOT are,are
R15460 T20631 T20630 acomp representative,are
R15461 T20632 T20631 prep for,representative
R15462 T20633 T20635 nummod 2,experiments
R15463 T20634 T20635 amod independent,experiments
R15464 T20635 T20632 pobj experiments,for
R15465 T20636 T20630 punct .,are
R15466 T20637 T20639 dep ***,<
R15467 T20638 T20639 dep p,<
R15468 T20639 T20640 intj <,"0,001"
R15469 T20640 T20640 ROOT "0,001","0,001"
R15470 T20641 T20640 punct .,"0,001"
R15666 T20969 T20970 nummod A20,deficiency
R15667 T20970 T20974 nsubj deficiency,protects
R15668 T20971 T20970 prep in,deficiency
R15669 T20972 T20973 amod myeloid,cells
R15670 T20973 T20971 pobj cells,in
R15671 T20974 T20974 ROOT protects,protects
R15672 T20975 T20974 prep against,protects
R15673 T20976 T20978 compound IAV,infection
R15674 T20977 T20978 compound lung,infection
R15675 T20978 T20975 pobj infection,against
R15676 T20979 T20974 punct .,protects
R15677 T20980 T20984 nsubj A20myel-WT,were
R15678 T20981 T20980 cc and,A20myel-WT
R15679 T20982 T20983 amod A20myel-KO,mice
R15680 T20983 T20980 conj mice,A20myel-WT
R15681 T20984 T20984 ROOT were,were
R15682 T20985 T20984 acomp infected,were
R15683 T20986 T20985 advmod intranasally,infected
R15684 T20987 T20985 prep with,infected
R15685 T20988 T20990 det a,dose
R15686 T20989 T20990 amod sublethal,dose
R15687 T20990 T20987 pobj dose,with
R15688 T20991 T20990 prep of,dose
R15689 T20992 T20991 pobj IAV,of
R15690 T20993 T20990 cc and,dose
R15691 T20994 T20995 compound weight,loss
R15692 T20995 T20990 conj loss,dose
R15693 T20996 T20997 auxpass was,monitored
R15694 T20997 T20984 conj monitored,were
R15695 T20998 T20999 punct (,A
R15696 T20999 T20997 oprd A,monitored
R15697 T21000 T20999 punct ),A
R15698 T21001 T20984 punct .,were
R15699 T21002 T21020 prep At,measured
R15700 T21003 T21002 pobj day,At
R15701 T21004 T21003 nummod 4,day
R15702 T21005 T21020 punct ",",measured
R15703 T21006 T21010 nummod 7,infection
R15704 T21007 T21006 cc and,7
R15705 T21008 T21006 conj 10,7
R15706 T21009 T21010 compound post,infection
R15707 T21010 T21015 nmod infection,titers
R15708 T21011 T21012 punct (,p.i.
R15709 T21012 T21010 appos p.i.,infection
R15710 T21013 T21010 punct ),infection
R15711 T21014 T21015 amod viral,titers
R15712 T21015 T21020 nsubjpass titers,measured
R15713 T21016 T21015 prep in,titers
R15714 T21017 T21018 det the,lung
R15715 T21018 T21016 pobj lung,in
R15716 T21019 T21020 auxpass were,measured
R15717 T21020 T21020 ROOT measured,measured
R15718 T21021 T21020 cc and,measured
R15719 T21022 T21020 conj expressed,measured
R15720 T21023 T21022 prep as,expressed
R15721 T21024 T21023 amod mean,as
R15722 T21025 T21024 nummod TCID50,mean
R15723 T21026 T21027 punct (,B
R15724 T21027 T21023 pobj B,as
R15725 T21028 T21022 punct ),expressed
R15726 T21029 T21020 punct .,measured
R15727 T21030 T21032 det The,line
R15728 T21031 T21032 amod dashed,line
R15729 T21032 T21033 nsubj line,represents
R15730 T21033 T21033 ROOT represents,represents
R15731 T21034 T21036 det the,limit
R15732 T21035 T21036 compound detection,limit
R15733 T21036 T21033 dobj limit,represents
R15734 T21037 T21033 punct .,represents
R15735 T21038 T21038 ROOT ND,ND
R15736 T21039 T21038 punct ",",ND
R15737 T21040 T21041 neg not,detectable
R15738 T21041 T21038 amod detectable,ND
R15739 T21042 T21038 punct .,ND
R15740 T21043 T21044 nsubj BAL,was
R15741 T21044 T21044 ROOT was,was
R15742 T21045 T21044 acomp isolated,was
R15743 T21046 T21045 prep from,isolated
R15744 T21047 T21049 amod IAV,mice
R15745 T21048 T21049 amod infected,mice
R15746 T21049 T21046 pobj mice,from
R15747 T21050 T21045 prep at,isolated
R15748 T21051 T21056 nummod 4,days
R15749 T21052 T21051 punct ",",4
R15750 T21053 T21051 conj 7,4
R15751 T21054 T21053 cc and,7
R15752 T21055 T21053 conj 10,7
R15753 T21056 T21057 npadvmod days,p.i.
R15754 T21057 T21069 nmod p.i.,levels
R15755 T21058 T21057 cc and,p.i.
R15756 T21059 T21057 conj KC,p.i.
R15757 T21060 T21059 punct ",",KC
R15758 T21061 T21059 conj MIP-2,KC
R15759 T21062 T21061 punct ",",MIP-2
R15760 T21063 T21061 conj MCP-1,MIP-2
R15761 T21064 T21063 punct ",",MCP-1
R15762 T21065 T21063 conj IL-6,MCP-1
R15763 T21066 T21065 cc and,IL-6
R15764 T21067 T21065 conj IFNα,IL-6
R15765 T21068 T21069 compound protein,levels
R15766 T21069 T21050 pobj levels,at
R15767 T21070 T21071 auxpass were,analyzed
R15768 T21071 T21044 conj analyzed,was
R15769 T21072 T21071 agent by,analyzed
R15770 T21073 T21072 pobj ELISA,by
R15771 T21074 T21071 cc and,analyzed
R15772 T21075 T21076 amod multiplexing,technologies
R15773 T21076 T21071 conj technologies,analyzed
R15774 T21077 T21078 punct (,C
R15775 T21078 T21076 appos C,technologies
R15776 T21079 T21076 punct ),technologies
R15777 T21080 T21044 punct .,was
R15778 T21081 T21082 amod Absolute,numbers
R15779 T21082 T21094 nsubjpass numbers,analyzed
R15780 T21083 T21082 prep of,numbers
R15781 T21084 T21086 compound resident,macrophages
R15782 T21085 T21086 compound alveolar,macrophages
R15783 T21086 T21083 pobj macrophages,of
R15784 T21087 T21086 punct ",",macrophages
R15785 T21088 T21086 conj neutrophils,macrophages
R15786 T21089 T21088 cc and,neutrophils
R15787 T21090 T21088 conj monocytes,neutrophils
R15788 T21091 T21086 prep in,macrophages
R15789 T21092 T21091 pobj BAL,in
R15790 T21093 T21094 auxpass were,analyzed
R15791 T21094 T21094 ROOT analyzed,analyzed
R15792 T21095 T21094 agent by,analyzed
R15793 T21096 T21095 pobj flow,by
R15794 T21097 T21094 npadvmod cytometry,analyzed
R15795 T21098 T21094 prep at,analyzed
R15796 T21099 T21104 nummod 4,days
R15797 T21100 T21099 punct ",",4
R15798 T21101 T21099 conj 7,4
R15799 T21102 T21101 cc and,7
R15800 T21103 T21101 conj 10,7
R15801 T21104 T21098 pobj days,at
R15802 T21105 T21094 conj p.i.,analyzed
R15803 T21106 T21107 punct (,D
R15804 T21107 T21105 appos D,p.i.
R15805 T21108 T21105 punct ),p.i.
R15806 T21109 T21094 punct .,analyzed
R15807 T21110 T21111 nsubj Numbers,are
R15808 T21111 T21111 ROOT are,are
R15809 T21112 T21111 attr averages,are
R15810 T21113 T21111 conj +,are
R15811 T21114 T21116 nummod /,SEM
R15812 T21115 T21116 nummod −,SEM
R15813 T21116 T21111 attr SEM,are
R15814 T21117 T21116 prep of,SEM
R15815 T21118 T21119 advmod at,least
R15816 T21119 T21120 advmod least,5
R15817 T21120 T21121 nummod 5,mice
R15818 T21121 T21117 pobj mice,of
R15819 T21122 T21121 prep per,mice
R15820 T21123 T21122 pobj group,per
R15821 T21124 T21111 cc and,are
R15822 T21125 T21111 conj are,are
R15823 T21126 T21125 attr representative,are
R15824 T21127 T21126 prep of,representative
R15825 T21128 T21130 nummod 2,experiments
R15826 T21129 T21130 amod independent,experiments
R15827 T21130 T21127 pobj experiments,of
R15828 T21131 T21125 punct .,are
R15829 T21132 T21138 punct *,p
R15830 T21133 T21138 ccomp p,p
R15831 T21134 T21135 compound <,0.05
R15832 T21135 T21133 nummod 0.05,p
R15833 T21136 T21138 punct ;,p
R15834 T21137 T21138 punct **,p
R15835 T21138 T21138 ROOT p,p
R15836 T21139 T21140 compound <,0.01
R15837 T21140 T21138 npadvmod 0.01,p
R15838 T21141 T21138 punct .,p
R15995 T21394 T21395 nummod A20,deficiency
R15996 T21395 T21399 nsubj deficiency,protects
R15997 T21396 T21395 prep in,deficiency
R15998 T21397 T21398 amod myeloid,cells
R15999 T21398 T21396 pobj cells,in
R16000 T21399 T21399 ROOT protects,protects
R16001 T21400 T21399 prep against,protects
R16002 T21401 T21403 amod lethal,infection
R16003 T21402 T21403 compound IAV,infection
R16004 T21403 T21400 pobj infection,against
R16005 T21404 T21399 punct .,protects
R16006 T21405 T21421 nsubjpass A20myel-WT,infected
R16007 T21406 T21409 punct (,11
R16008 T21407 T21409 advmod n,11
R16009 T21408 T21409 punct =,11
R16010 T21409 T21418 nmod 11,mice
R16011 T21410 T21409 punct ),11
R16012 T21411 T21409 cc and,11
R16013 T21412 T21409 conj A20myel-KO,11
R16014 T21413 T21416 punct (,11
R16015 T21414 T21416 advmod n,11
R16016 T21415 T21416 punct =,11
R16017 T21416 T21418 nummod 11,mice
R16018 T21417 T21418 nmod ),mice
R16019 T21418 T21421 nsubjpass mice,infected
R16020 T21419 T21421 auxpass were,infected
R16021 T21420 T21421 advmod intranasally,infected
R16022 T21421 T21421 ROOT infected,infected
R16023 T21422 T21421 prep with,infected
R16024 T21423 T21425 det a,dose
R16025 T21424 T21425 amod lethal,dose
R16026 T21425 T21422 pobj dose,with
R16027 T21426 T21425 prep of,dose
R16028 T21427 T21426 pobj IAV,of
R16029 T21428 T21425 cc and,dose
R16030 T21429 T21425 conj survival,dose
R16031 T21430 T21429 punct (,survival
R16032 T21431 T21432 nmod p,<
R16033 T21432 T21433 nmod <,0.001
R16034 T21433 T21429 appos 0.001,survival
R16035 T21434 T21429 punct ),survival
R16036 T21435 T21425 punct (,dose
R16037 T21436 T21425 appos A,dose
R16038 T21437 T21425 punct ),dose
R16039 T21438 T21425 cc and,dose
R16040 T21439 T21440 compound weight,loss
R16041 T21440 T21425 conj loss,dose
R16042 T21441 T21449 advmod +,monitored
R16043 T21442 T21444 nummod /,SEM
R16044 T21443 T21444 nummod −,SEM
R16045 T21444 T21449 nsubjpass SEM,monitored
R16046 T21445 T21446 punct (,B
R16047 T21446 T21444 appos B,SEM
R16048 T21447 T21446 punct ),B
R16049 T21448 T21449 auxpass was,monitored
R16050 T21449 T21421 conj monitored,infected
R16051 T21450 T21449 prep for,monitored
R16052 T21451 T21452 advmod respectively,21
R16053 T21452 T21455 nummod 21,days
R16054 T21453 T21452 cc and,21
R16055 T21454 T21452 conj 15,21
R16056 T21455 T21450 pobj days,for
R16057 T21456 T21457 compound p.i.,BAL
R16058 T21457 T21458 compound BAL,fluid
R16059 T21458 T21460 nsubjpass fluid,collected
R16060 T21459 T21460 auxpass was,collected
R16061 T21460 T21421 conj collected,infected
R16062 T21461 T21460 prep from,collected
R16063 T21462 T21463 amod wild,type
R16064 T21463 T21461 pobj type,from
R16065 T21464 T21463 punct (,type
R16066 T21465 T21463 appos A20myel-WT,type
R16067 T21466 T21463 punct ),type
R16068 T21467 T21461 cc and,from
R16069 T21468 T21469 amod A20myel-KO,mice
R16070 T21469 T21492 nsubjpass mice,determined
R16071 T21470 T21471 nummod 6,days
R16072 T21471 T21472 npadvmod days,following
R16073 T21472 T21469 acl following,mice
R16074 T21473 T21472 dobj infection,following
R16075 T21474 T21473 prep with,infection
R16076 T21475 T21477 det a,dose
R16077 T21476 T21477 amod lethal,dose
R16078 T21477 T21474 pobj dose,with
R16079 T21478 T21490 nmod IAV,levels
R16080 T21479 T21478 cc and,IAV
R16081 T21480 T21478 conj KC,IAV
R16082 T21481 T21480 punct ",",KC
R16083 T21482 T21480 conj MIP-2,KC
R16084 T21483 T21482 punct ",",MIP-2
R16085 T21484 T21482 conj MCP-1,MIP-2
R16086 T21485 T21484 punct ",",MCP-1
R16087 T21486 T21484 conj IL-6,MCP-1
R16088 T21487 T21486 cc and,IL-6
R16089 T21488 T21486 conj IFNα,IL-6
R16090 T21489 T21490 compound protein,levels
R16091 T21490 T21492 nsubjpass levels,determined
R16092 T21491 T21492 auxpass were,determined
R16093 T21492 T21492 ROOT determined,determined
R16094 T21493 T21492 punct (,determined
R16095 T21494 T21492 npadvmod C,determined
R16096 T21495 T21492 punct ),determined
R16097 T21496 T21492 punct .,determined
R16098 T21497 T21498 amod Absolute,numbers
R16099 T21498 T21509 nsubjpass numbers,analyzed
R16100 T21499 T21498 prep of,numbers
R16101 T21500 T21501 compound alveolar,macrophages
R16102 T21501 T21499 pobj macrophages,of
R16103 T21502 T21501 punct ",",macrophages
R16104 T21503 T21501 conj neutrophils,macrophages
R16105 T21504 T21503 cc and,neutrophils
R16106 T21505 T21503 conj monocytes,neutrophils
R16107 T21506 T21498 prep in,numbers
R16108 T21507 T21506 pobj BAL,in
R16109 T21508 T21509 auxpass were,analyzed
R16110 T21509 T21509 ROOT analyzed,analyzed
R16111 T21510 T21509 agent by,analyzed
R16112 T21511 T21512 compound flow,cytometry
R16113 T21512 T21510 pobj cytometry,by
R16114 T21513 T21509 prep at,analyzed
R16115 T21514 T21515 nummod 6,days
R16116 T21515 T21516 compound days,p.i.
R16117 T21516 T21513 pobj p.i.,at
R16118 T21517 T21516 punct (,p.i.
R16119 T21518 T21516 appos D,p.i.
R16120 T21519 T21516 punct ),p.i.
R16121 T21520 T21509 punct .,analyzed
R16122 T21521 T21522 nsubj Numbers,are
R16123 T21522 T21522 ROOT are,are
R16124 T21523 T21522 attr averages,are
R16125 T21524 T21522 conj +,are
R16126 T21525 T21527 nummod /,SEM
R16127 T21526 T21527 nummod −,SEM
R16128 T21527 T21522 npadvmod SEM,are
R16129 T21528 T21527 prep of,SEM
R16130 T21529 T21530 advmod at,least
R16131 T21530 T21531 advmod least,5
R16132 T21531 T21532 nummod 5,mice
R16133 T21532 T21528 pobj mice,of
R16134 T21533 T21532 prep per,mice
R16135 T21534 T21533 pobj group,per
R16136 T21535 T21522 punct .,are
R16137 T21536 T21537 nsubj Data,are
R16138 T21537 T21537 ROOT are,are
R16139 T21538 T21537 attr representative,are
R16140 T21539 T21538 prep of,representative
R16141 T21540 T21542 nummod 2,experiments
R16142 T21541 T21542 amod independent,experiments
R16143 T21542 T21539 pobj experiments,of
R16144 T21543 T21537 punct .,are
R16145 T21544 T21546 punct *,<
R16146 T21545 T21546 compound p,<
R16147 T21546 T21546 ROOT <,<
R16148 T21547 T21546 nummod 0.05,<
R16149 T21548 T21546 punct ;,<
R16150 T21549 T21552 punct **,0.01
R16151 T21550 T21552 amod p,0.01
R16152 T21551 T21552 compound <,0.01
R16153 T21552 T21556 dep 0.01,<
R16154 T21553 T21552 punct ",",0.01
R16155 T21554 T21556 dep ***,<
R16156 T21555 T21556 dep p,<
R16157 T21556 T21557 dep <,0.001
R16158 T21557 T21546 appos 0.001,<
R16159 T21558 T21546 punct .,<
R11927 T15855 T15862 nsubj Determination,titers
R11928 T15856 T15855 prep of,Determination
R11929 T15857 T15856 pobj HAI,of
R11930 T15858 T15860 punct (,inhibition
R11931 T15859 T15860 compound hemagglutination,inhibition
R11932 T15860 T15857 appos inhibition,HAI
R11933 T15861 T15857 punct ),HAI
R11934 T15862 T15876 nsubjpass titers,treated
R11935 T15863 T15864 aux To,determine
R11936 T15864 T15862 advcl determine,titers
R11937 T15865 T15867 det the,titers
R11938 T15866 T15867 compound HAI,titers
R11939 T15867 T15864 dobj titers,determine
R11940 T15868 T15867 prep in,titers
R11941 T15869 T15870 amod infected,mice
R11942 T15870 T15868 pobj mice,in
R11943 T15871 T15867 punct ",",titers
R11944 T15872 T15867 appos sera,titers
R11945 T15873 T15872 prep of,sera
R11946 T15874 T15873 pobj these,of
R9977 T13414 T13397 punct .,supports
R9978 T13415 T13416 compound MCP-1,levels
R9979 T13416 T13419 nsubjpass levels,affected
R9980 T13417 T13419 auxpass were,affected
R9981 T13418 T13419 neg not,affected
R9982 T13419 T13419 ROOT affected,affected
R10063 T13500 T13501 compound proinflammatory,macrophages
R10218 T13655 T13656 amod immune,response
R10292 T13729 T13730 aux may,contribute
R10293 T13730 T13727 relcl contribute,pathways
R10294 T13731 T13730 prep to,contribute
R10295 T13732 T13734 amod proinflammatory,expression
R10478 T13887 T13886 prep of,topic
R10479 T13888 T13889 amod future,investigations
R10481 T13889 T13887 pobj investigations,of
R10482 T13890 T13889 prep in,investigations
R10483 T13891 T13892 poss our,laboratory
R10484 T13892 T13890 pobj laboratory,in
R10485 T13893 T13884 punct .,be
R10575 T14051 T14047 pobj responses,of
R10576 T14052 T14052 ROOT is,is
R10578 T14053 T14055 det an,step
R10579 T14054 T14055 amod important,step
R10581 T14055 T14052 attr step,is
R10582 T14056 T14055 prep toward,step
R10583 T14057 T14058 compound novel,therapies
R10675 T14123 T14122 punct (,RNA
R10676 T14124 T14122 appos siRNA,RNA
R10678 T14125 T14122 punct ),RNA
R10679 T14126 T14129 punct ",",evolved
R10680 T14127 T14129 aux has,evolved
R10682 T14128 T14129 advmod rapidly,evolved
R10684 T14129 T14129 ROOT evolved,evolved
R10685 T14130 T14129 prep as,evolved
R10686 T14131 T14134 det a,regimen
R10687 T14132 T14134 amod potent,regimen
R10689 T14133 T14134 amod antiviral,regimen
R10690 T14134 T14130 pobj regimen,as
R10793 T14210 T14211 amod immune,response
R10784 T14202 T14201 acl targeting,siRNA
R10785 T14203 T14204 compound IAV,components
R10787 T14204 T14202 dobj components,targeting
R10788 T14205 T14202 punct ",",targeting
R10789 T14206 T14202 cc but,targeting
R10790 T14207 T14202 conj boosting,targeting
R10791 T14208 T14211 det the,response
R10792 T14209 T14211 amod antiviral,response
R7432 T10184 T10182 pobj mice,of
R7433 T10185 T10193 mark while,isolated
R7434 T10186 T10189 amod abundant,particles
R7435 T10187 T10189 amod infectious,particles
R7436 T10188 T10189 amod viral,particles
R7437 T10189 T10193 nsubjpass particles,isolated
R7438 T10190 T10193 aux could,isolated
R7439 T10191 T10193 advmod still,isolated
R7440 T10192 T10193 auxpass be,isolated
R7502 T10254 T10252 pobj chemokines,of
R7503 T10255 T10254 cc and,chemokines
R12912 T17064 T17061 pobj FCS,with
R12913 T17065 T17064 punct ",",FCS
R5818 T8191 T8180 punct .,contained
R5819 T8192 T8200 prep Upon,are
R5820 T8193 T8194 compound host,infection
R5821 T8194 T8192 pobj infection,Upon
R5822 T8195 T8194 prep with,infection
R5823 T8196 T8195 pobj IAV,with
R5824 T8197 T8200 punct ",",are
R5825 T8198 T8199 amod alveolar,macrophages
R5826 T8199 T8200 nsubj macrophages,are
R11565 T15463 T15464 amod Viral,infection
R11566 T15464 T15471 nsubj infection,adapted
R11567 T15465 T15464 cc and,infection
R11568 T15466 T15464 conj determination,infection
R11569 T15467 T15466 prep of,determination
R11570 T15468 T15469 amod viral,titers
R11571 T15469 T15467 pobj titers,of
R11572 T15470 T15471 nsubj Mouse,adapted
R11573 T15471 T15471 ROOT adapted,adapted
R11574 T15472 T15473 compound IAV,X-47
R11575 T15473 T15471 dobj X-47,adapted
R11576 T15474 T15475 punct (,H3N2
R11577 T15475 T15473 appos H3N2,X-47
R11626 T15524 T15523 cc and,lethal
R11627 T15525 T15523 conj sublethal,lethal
R11628 T15526 T15522 pobj infection,For
R11629 T15527 T15529 punct ",",received
R11630 T15528 T15529 nsubj mice,received
R11631 T15529 T15529 ROOT received,received
R11632 T15530 T15531 advmod respectively,2-LD50
R11633 T15531 T15534 amod 2-LD50,X-47
R11634 T15532 T15531 cc or,2-LD50
R11635 T15533 T15531 conj 0.05-LD50,2-LD50
R11636 T15534 T15529 dobj X-47,received
R11637 T15535 T15529 punct .,received
R11638 T15536 T15537 aux To,determine
R11639 T15537 T15551 advcl determine,measured
R11640 T15538 T15540 amod pulmonary,titers
R11641 T15539 T15540 amod viral,titers
R11642 T15540 T15537 dobj titers,determine
R11643 T15541 T15540 punct ",",titers
R11644 T15542 T15544 amod median,culture
R11645 T15543 T15544 compound tissue,culture
R11646 T15544 T15540 appos culture,titers
R11647 T15545 T15546 amod infectious,dose
R11648 T15546 T15540 appos dose,titers
R11649 T15547 T15546 punct (,dose
R11650 T15548 T15546 appos TCID50,dose
R11651 T15549 T15546 punct ),dose
R15396 T20567 T20567 ROOT treated,treated
R15397 T20568 T20567 cc or,treated
R15398 T20569 T20567 conj infected,treated
R15399 T20570 T20569 prep with,infected
R15400 T20571 T20570 pobj IAV,with
R15401 T20572 T20571 punct (,IAV
R15402 T20573 T20574 nmod moi,1
R15403 T20574 T20576 meta 1,for
R15404 T20575 T20574 punct ),1
R15405 T20576 T20569 prep for,infected
R15406 T20577 T20578 nummod 18,hours
R15407 T20578 T20576 pobj hours,for
R15408 T20579 T20567 punct .,treated
R15409 T20580 T20586 nsubjpass IL-6,determined
R15410 T20581 T20580 cc and,IL-6
R15411 T20582 T20583 compound IFNβ,mRNA
R4126 T5867 T5859 appos factors,activation
R4127 T5868 T5859 punct ",",activation
R4128 T5869 T5870 nsubj which,promote
R4129 T5870 T5859 relcl promote,activation
R4130 T5871 T5872 det the,expression
R4131 T5872 T5870 dobj expression,promote
R4132 T5873 T5872 prep of,expression
R4133 T5874 T5875 amod proinflammatory,cytokines
R4134 T5875 T5873 pobj cytokines,of
R4135 T5876 T5875 cc and,cytokines
R4136 T5877 T5875 conj type,cytokines
R4137 T5878 T5879 nsubj I,IFNs
R4138 T5879 T5879 ROOT IFNs,IFNs
R4139 T5880 T5881 mark that,restrict
R4140 T5881 T5879 ccomp restrict,IFNs
R4141 T5882 T5884 amod further,propagation
R4190 T5930 T5929 agent by,induced
R4193 T5931 T5930 pobj transfection,by
R4197 T5932 T5931 prep of,transfection
R4200 T5933 T5937 det a,form
R4203 T5934 T5937 amod truncated,form
R4207 T5935 T5937 amod constitutive,form
R4210 T5936 T5937 amod active,form
R4214 T5937 T5932 pobj form,of
R4218 T5938 T5937 prep of,form
R4222 T5939 T5940 compound RIG-I,[
R4227 T5940 T5938 pobj [,of
R4234 T5941 T5942 nummod 53,]
R4239 T5942 T5937 appos ],form
R4243 T5943 T5928 punct ",",activation
R4247 T5944 T5964 amod corresponding,left
R4507 T6114 T6115 det These,results
R4189 T5945 T5964 advmod to,left
R4191 T5946 T5951 advmod only,domains
R4192 T5947 T5951 det the,domains
R4194 T5948 T5951 nummod two,domains
R4195 T5949 T5950 compound N-terminal,CARD
R4196 T5950 T5951 compound CARD,domains
R4198 T5951 T5964 nsubj domains,left
R4199 T5952 T5951 prep of,domains
R4201 T5953 T5955 compound RIG-I,RIG-I
R4202 T5954 T5955 compound [,RIG-I
R4204 T5955 T5952 pobj RIG-I,of
R4205 T5956 T5955 punct (,RIG-I
R4206 T5957 T5955 appos 2CARD,RIG-I
R4208 T5958 T5955 punct ),RIG-I
R4209 T5959 T5955 conj ],RIG-I
R4275 T6008 T6009 nummod 55,]
R4276 T6009 T6005 appos ],]
R4277 T6010 T5988 punct .,expressed
R4279 T6011 T6012 aux To,determine
R4280 T6012 T6023 advcl determine,transfected
R4281 T6013 T6014 det the,effect
R4282 T6014 T6012 dobj effect,determine
R4283 T6015 T6014 prep of,effect
R4285 T6016 T6015 pobj A20,of
R4286 T6017 T6014 prep on,effect
R4287 T6018 T6019 compound IRF7,activation
R4289 T6019 T6017 pobj activation,on
R4290 T6020 T6023 punct ",",transfected
R4292 T6021 T6023 nsubj we,transfected
R4293 T6022 T6023 advmod therefore,transfected
R4294 T6023 T6023 ROOT transfected,transfected
R4296 T6024 T6025 amod minor,amounts
R4297 T6025 T6023 dobj amounts,transfected
R4298 T6026 T6025 prep of,amounts
R4300 T6027 T6030 det an,plasmid
R4301 T6028 T6029 compound IRF7,expression
R4302 T6029 T6030 compound expression,plasmid
R4304 T6030 T6026 pobj plasmid,of
R4305 T6031 T6032 advmod together,with
R4306 T6032 T6023 prep with,transfected
R4308 T6033 T6034 nsubj plasmids,encoding
R4309 T6034 T6047 advcl encoding,construct
R4310 T6035 T6047 nsubj RIG-I,construct
R4324 T6139 T6137 pobj signaling,on
R4325 T6140 T6130 prep in,study
R4327 T6141 T6145 det a,context
R4328 T6142 T6143 advmod more,immunological
R4329 T6143 T6145 amod immunological,context
R4330 T6144 T6145 amod relevant,context
R4331 T6145 T6140 pobj context,in
R4333 T6146 T6148 punct ",",performed
R4334 T6147 T6148 nsubj we,performed
R4335 T6148 T6148 ROOT performed,performed
R4336 T6149 T6150 amod further,experiments
R4338 T6150 T6148 dobj experiments,performed
R4339 T6151 T6150 prep in,experiments
R4340 T6152 T6151 pobj A20,in
R4342 T6153 T6155 amod deficient,macrophages
R4343 T6154 T6155 amod primary,macrophages
R4377 T6178 T6177 acl carrying,mice
R4378 T6179 T6182 det a,allele
R4380 T6180 T6182 amod conditional,allele
R4381 T6181 T6182 compound A20,allele
R4382 T6182 T6178 dobj allele,carrying
R4383 T6183 T6191 prep in,flanked
R4384 T6184 T6183 pobj which,in
R4386 T6185 T6186 compound exon,IV
R4387 T6186 T6191 nsubjpass IV,flanked
R4388 T6187 T6186 cc and,IV
R4390 T6188 T6189 compound exon,V
R4391 T6189 T6186 conj V,IV
R4392 T6190 T6191 auxpass were,flanked
R4394 T6191 T6182 relcl flanked,allele
R4395 T6192 T6191 agent by,flanked
R4396 T6193 T6195 nummod two,sites
R4399 T6194 T6195 compound loxP,sites
R4401 T6195 T6192 pobj sites,by
R4402 T6196 T6195 appos [,sites
R4403 T6197 T6198 nummod 56,]
R4405 T6198 T6196 appos ],[
R4406 T6199 T6176 punct .,generated
R4407 T6200 T6216 csubj Crossing,leads
R4409 T6201 T6202 det these,mice
R4410 T6202 T6200 dobj mice,Crossing
R4412 T6203 T6200 prep with,Crossing
R4413 T6204 T6205 amod transgenic,mice
R4414 T6205 T6203 pobj mice,with
R4416 T6206 T6205 acl expressing,mice
R4417 T6207 T6208 compound Cre,recombinase
R4418 T6208 T6206 dobj recombinase,expressing
R4419 T6209 T6206 prep under,expressing
R4484 T6257 T6259 amod low,weight
R4485 T6258 T6259 amod molecular,weight
R4487 T6259 T6256 pobj weight,of
R4488 T6260 T6259 punct (,weight
R4490 T6261 T6259 appos LMW,weight
R4491 T6262 T6263 punct ),poly
R4492 T6263 T6259 appos poly,weight
R4494 T6264 T6267 punct (,C
R4495 T6265 T6267 nsubj I,C
R4496 T6266 T6267 punct :,C
R4498 T6267 T6263 parataxis C,poly
R4499 T6268 T6267 punct ),C
R4500 T6269 T6267 punct ",",C
R4501 T6270 T6272 nsubjpass which,known
R4503 T6271 T6272 auxpass is,known
R4506 T6272 T6267 relcl known,C
R4508 T6273 T6275 aux to,bind
R4509 T6274 T6275 advmod preferentially,bind
R4510 T6275 T6272 xcomp bind,known
R4512 T6276 T6275 cc and,bind
R4513 T6277 T6275 conj activate,bind
R4514 T6278 T6277 dobj RIG-I,activate
R4516 T6279 T6280 advmod rather,than
R4748 T6548 T6545 appos 1C,cells
R4749 T6549 T6545 punct ),cells
R4750 T6550 T6529 punct .,reached
R4752 T6551 T6552 nsubj NF-κB,controls
R4753 T6552 T6552 ROOT controls,controls
R4754 T6553 T6554 det the,expression
R4756 T6554 T6552 dobj expression,controls
R4757 T6555 T6554 prep of,expression
R4758 T6556 T6555 pobj IL-6,of
R4760 T6557 T6556 cc and,IL-6
R4761 T6558 T6556 conj TNF,IL-6
R4762 T6559 T6552 punct ",",controls
R4764 T6560 T6552 cc and,controls
R4765 T6561 T6564 nsubj NF-κB,control
R4767 T6562 T6561 cc and,NF-κB
R4768 T6563 T6561 conj IRF3,NF-κB
R4769 T6564 T6552 conj control,controls
R4834 T6611 T6606 punct ),macrophages
R4835 T6612 T6603 punct .,obtained
R4836 T6613 T6617 advmod Together,demonstrate
R4838 T6614 T6617 punct ",",demonstrate
R4839 T6615 T6616 det these,results
R4840 T6616 T6617 nsubj results,demonstrate
R4842 T6617 T6617 ROOT demonstrate,demonstrate
R4843 T6618 T6620 mark that,plays
R4844 T6619 T6620 nsubj A20,plays
R4846 T6620 T6617 ccomp plays,demonstrate
R4847 T6621 T6623 det an,role
R4849 T6622 T6623 amod important,role
R4850 T6623 T6620 dobj role,plays
R4851 T6624 T6623 prep in,role
R4853 T6625 T6627 det the,regulation
R4854 T6626 T6627 amod negative,regulation
R2599 T3329 T3323 conj ],]
R2600 T3330 T3290 punct .,shown
R2601 T3331 T3333 det The,role
R2603 T3332 T3333 amod anti-inflammatory,role
R2615 T3340 T3341 det the,fact
R2582 T3318 T3315 conj ],]
R2584 T3319 T3318 punct ",",]
R2585 T3320 T3323 nummod TLR4,]
R2586 T3321 T3323 nmod [,]
R2589 T3322 T3323 nummod 40,]
R2590 T3323 T3318 conj ],]
R2592 T3324 T3323 punct ",",]
R2593 T3325 T3323 cc and,]
R2595 T3326 T3327 compound IL-1R,[
R2596 T3327 T3323 conj [,]
R2597 T3328 T3329 nummod 41,]
R2604 T3333 T3338 nsubjpass role,demonstrated
R2606 T3334 T3333 prep of,role
R2607 T3335 T3334 pobj A20,of
R2608 T3336 T3338 auxpass is,demonstrated
R2609 T3337 T3338 advmod clearly,demonstrated
R2611 T3338 T3338 ROOT demonstrated,demonstrated
R2612 T3339 T3338 agent by,demonstrated
R2619 T3341 T3339 pobj fact,by
R2620 T3342 T3346 mark that,die
R2622 T3343 T3345 nummod A20,mice
R2623 T3344 T3345 amod deficient,mice
R2625 T3345 T3346 nsubj mice,die
R2626 T3346 T3341 acl die,fact
R2627 T3347 T3348 advmod early,after
R2629 T3348 T3346 prep after,die
R2630 T3349 T3348 pobj birth,after
R2631 T3350 T3341 amod due,fact
R2633 T3351 T3350 prep to,due
R2634 T3352 T3354 amod severe,inflammation
R2635 T3353 T3354 amod multi-organ,inflammation
R2636 T3354 T3351 pobj inflammation,to
R2637 T3355 T3354 cc and,inflammation
R2639 T3356 T3354 conj cachexia,inflammation
R2640 T3357 T3359 nmod [,]
R2641 T3358 T3359 nummod 37,]
R2643 T3359 T3356 appos ],cachexia
R2644 T3360 T3338 punct .,demonstrated
R2645 T3361 T3362 advmod More,recently
R2646 T3362 T3365 advmod recently,targeting
R2647 T3363 T3365 punct ",",targeting
R2642 T3419 T3418 prep in,polymorphisms
R2648 T3420 T3422 det the,locus
R2693 T3397 T3396 prep on,brake
R2695 T3398 T3400 det the,response
R2696 T3399 T3400 amod inflammatory,response
R2697 T3400 T3397 pobj response,on
R2699 T3401 T3373 punct .,shown
R2700 T3402 T3403 det The,relevance
R2701 T3403 T3413 nsubjpass relevance,illustrated
R2703 T3404 T3403 prep of,relevance
R2704 T3405 T3406 det these,findings
R2706 T3406 T3404 pobj findings,of
R2707 T3407 T3403 prep for,relevance
R2708 T3408 T3409 amod human,disease
R2710 T3409 T3407 pobj disease,for
R2711 T3410 T3413 aux has,illustrated
R2712 T3411 T3413 advmod recently,illustrated
R2714 T3412 T3413 auxpass been,illustrated
R2715 T3413 T3413 ROOT illustrated,illustrated
R2716 T3414 T3413 prep through,illustrated
R2718 T3415 T3416 det the,identification
R2719 T3416 T3414 pobj identification,through
R2720 T3417 T3416 prep of,identification
R2722 T3418 T3417 pobj polymorphisms,of

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T561 0-3 Protein denotes A20
T562 5-12 Protein denotes Tnfaip3
T563 14-24 Negative_regulation denotes Deficiency
T564 14-24 Negative_regulation denotes Deficiency
T21159 19436-19448 Protein denotes IFNα protein
T21158 19427-19431 Protein denotes IL-6
T21157 19420-19425 Protein denotes MCP-1
T21156 19413-19418 Protein denotes MIP-2
T21155 19409-19411 Protein denotes KC
T21154 18971-18981 Negative_regulation denotes deficiency
T21153 18967-18970 Protein denotes A20
T21588 25084-25096 Protein denotes IFNα protein
T21587 25075-25079 Protein denotes IL-6
T21586 25068-25073 Protein denotes MCP-1
T21585 25061-25066 Protein denotes MIP-2
T21584 25057-25059 Protein denotes KC
T21583 24656-24666 Negative_regulation denotes deficiency
T21582 24652-24655 Protein denotes A20
T20115 12234-12240 Gene_expression denotes levels
T20114 12234-12240 Gene_expression denotes levels
T20113 12234-12240 Gene_expression denotes levels
T20112 12335-12339 Protein denotes IFNβ
T20111 12327-12330 Protein denotes TNF
T20110 12320-12325 Protein denotes ELISA
T20109 12229-12233 Protein denotes IFNβ
T20108 12221-12224 Protein denotes TNF
T20107 12215-12219 Protein denotes IL-6
T20106 12145-12154 Gene_expression denotes expressed
T20105 12145-12154 Gene_expression denotes expressed
T20104 12116-12120 Protein denotes IRF3
T20103 12108-12111 Protein denotes p65
T20102 11955-11968 Localization denotes translocation
T20101 11955-11968 Localization denotes translocation
T20100 11955-11968 Localization denotes translocation
T20099 11947-11954 Entity denotes Nuclear
T20098 11988-11992 Protein denotes IRF3
T20097 11979-11982 Protein denotes p65
T20096 11972-11977 Protein denotes NF-κB
T20095 11849-11859 Binding denotes recognized
T20094 11867-11885 Protein denotes anti-IκBα antibody
T20093 11753-11768 Phosphorylation denotes phosphorylation
T20092 11731-11742 Protein_catabolism denotes degradation
T20091 11711-11726 Phosphorylation denotes phosphorylation
T20090 11748-11752 Protein denotes IRF3
T20089 11706-11710 Protein denotes IκBα
T20088 11416-11426 Protein denotes Luciferase
T20087 11346-11356 Gene_expression denotes expressing
T20086 11346-11356 Gene_expression denotes expressing
T20085 11222-11233 Gene_expression denotes transfected
T20084 11222-11233 Gene_expression denotes transfected
T20083 11411-11414 Protein denotes A20
T20082 11372-11376 Protein denotes IRF7
T20081 11270-11304 Protein denotes IRF7 dependent luciferase reporter
T20080 11253-11257 Protein denotes IRF3
T20079 11239-11244 Protein denotes NF-κB
T20078 11130-11138 Negative_regulation denotes inhibits
T20077 11130-11138 Negative_regulation denotes inhibits
T20076 11154-11164 Positive_regulation denotes activation
T20075 11154-11164 Positive_regulation denotes activation
T20074 11180-11185 Protein denotes RIG-I
T20073 11149-11153 Protein denotes IRF3
T20072 11139-11144 Protein denotes NF-κB
T20071 11126-11129 Protein denotes A20
T20680 16128-16132 Protein denotes IFNβ
T20679 16122-16126 Protein denotes IL-6
T20678 15876-15879 Protein denotes A20
T20692 16518-16530 Protein denotes IFNβ protein
T20691 16509-16513 Protein denotes IL-6
T20690 16428-16438 Gene_expression denotes expression
T20689 16428-16438 Gene_expression denotes expression
T20688 16418-16427 Protein denotes IFNβ mRNA
T20687 16409-16413 Protein denotes IL-6
T20686 16257-16269 Protein denotes IFNβ protein
T20685 16249-16252 Protein denotes TNF
T20684 16146-16156 Gene_expression denotes expression
T20683 16146-16156 Gene_expression denotes expression
T20682 16146-16156 Gene_expression denotes expression
T20681 16137-16145 Protein denotes A20 mRNA
T19050 41106-41111 Protein denotes IFNα4
T19049 41037-41042 Protein denotes CXCL1
T19048 40831-40835 Protein denotes IFNβ
T19047 40588-40608 Protein denotes Green I master mix I
T19046 40486-40495 Gene_expression denotes synthesis
T19045 40473-40485 Protein denotes iScript cDNA
T18571 40310-40315 Protein denotes MIP-2
T18570 40096-40105 Gene_expression denotes Detection
T18569 40096-40105 Gene_expression denotes Detection
T18568 40096-40105 Gene_expression denotes Detection
T18567 40096-40105 Gene_expression denotes Detection
T18566 40096-40105 Gene_expression denotes Detection
T18565 40135-40139 Protein denotes IL-6
T18564 40125-40130 Protein denotes IL-1β
T18563 40120-40123 Protein denotes TNF
T18562 40116-40118 Protein denotes KC
T18561 40109-40114 Protein denotes MCP-1
T18560 39980-39990 Protein denotes IFNγ ELISA
T18559 39882-39903 Protein denotes IFNα and IFNβ protein
T18558 39800-39803 Protein denotes TNF
T18557 39757-39766 Protein denotes TNF ELISA
T19053 41332-41341 Gene_expression denotes expressed
T19052 41354-41358 Protein denotes HPRT
T19051 40577-40582 Gene_expression denotes using
T18182 39544-39557 Protein denotes BD Pharmingen
T18181 39474-39509 Protein denotes CD8α PerCP (53-6.7), IFNγ Alexa 647
T18180 39451-39456 Protein denotes CD11b
T18179 39445-39448 Protein denotes 1A8
T18178 39436-39443 Protein denotes Ly6G PE
T18177 39409-39426 Protein denotes Ly6C Horizon v450
T18176 39302-39307 Protein denotes CD62L
T18175 39259-39264 Protein denotes CD11c
T18174 38886-38897 Protein denotes collagenase
T17734 38610-38620 Protein denotes anti-actin
T17111 37201-37206 Protein denotes CD11b
T17110 36336-36346 Gene_expression denotes expression
T17109 36336-36346 Gene_expression denotes expression
T17108 36336-36346 Gene_expression denotes expression
T17107 36336-36346 Gene_expression denotes expression
T17106 36336-36346 Gene_expression denotes expression
T17105 36336-36346 Gene_expression denotes expression
T17104 36336-36346 Gene_expression denotes expression
T17103 36336-36346 Gene_expression denotes expression
T17102 36336-36346 Gene_expression denotes expression
T17101 36741-36749 Protein denotes LMBP4341
T17100 36728-36739 Protein denotes pACTbetagal
T17099 36631-36645 Protein denotes pGL3-IFNα4-luc
T17098 36620-36628 Protein denotes LMBP4011
T17097 36609-36618 Protein denotes pISRE-luc
T17096 36552-36556 Protein denotes IRF7
T17095 36546-36550 Protein denotes IRF3
T17094 36539-36544 Protein denotes NF-κB
T17093 36416-36428 Protein denotes pEF-HA-IRF-7
T17092 36108-36112 Protein denotes MDCK
T16464 35951-35961 Gene_expression denotes expression
T16463 35951-35961 Gene_expression denotes expression
T16462 35946-35950 Protein denotes CD8+
T16461 35930-35940 Protein denotes CD62lo CD3
T16460 35876-35880 Protein denotes CD8+
T16459 35728-35739 Protein denotes Brefeldin A
T16458 35471-35481 Gene_expression denotes expressing
T16457 35471-35481 Gene_expression denotes expressing
T16456 35471-35481 Gene_expression denotes expressing
T16455 35569-35574 Protein denotes Sigma
T16454 35556-35567 Protein denotes Brefeldin A
T16453 35482-35486 Protein denotes CD8+
T16452 35466-35470 Protein denotes IFNγ
T16451 35457-35460 Protein denotes GrB
T16450 35445-35455 Protein denotes Granzyme B
T16449 35410-35418 Gene_expression denotes staining
T16448 35410-35418 Gene_expression denotes staining
T16447 35432-35436 Protein denotes CD8+
T16446 35405-35409 Protein denotes IFNγ
T16445 35397-35400 Protein denotes GrB
T16047 35209-35212 Protein denotes PR8
T16046 35154-35165 Protein denotes PBS instead
T16045 35078-35081 Protein denotes RBC
T16044 34442-34445 Protein denotes HAI
T15645 34087-34094 Protein denotes trypsin
T14490 31989-31998 Localization denotes targeting
T14489 32090-32106 Protein denotes SARS coronavirus
T14488 32002-32005 Protein denotes A20
T14487 31854-31857 Protein denotes A20
T14486 30610-30613 Protein denotes A20
T14485 30410-30420 Gene_expression denotes expression
T14484 30465-30470 Protein denotes RIG-I
T14483 30406-30409 Protein denotes A20
T14482 30172-30177 Protein denotes IRF-3
T14481 30162-30167 Protein denotes NF-κB
T14480 30143-30148 Protein denotes RIG-I
T14479 29835-29842 Positive_regulation denotes mediate
T14478 29835-29842 Positive_regulation denotes mediate
T14477 29858-29868 Positive_regulation denotes activation
T14476 29858-29868 Positive_regulation denotes activation
T14475 29853-29857 Protein denotes IRF3
T14474 29843-29848 Protein denotes NF-κB
T14473 29796-29799 Protein denotes A20
T14472 29718-29728 Negative_regulation denotes deficiency
T14471 29714-29717 Protein denotes A20
T14470 29634-29647 Protein denotes TBK1 and IKKε
T14469 29541-29546 Protein denotes NF-κB
T14468 29527-29532 Protein denotes RIG-I
T14467 29271-29278 Binding denotes binding
T14466 29404-29408 Protein denotes TBK1
T14465 29330-29334 Protein denotes TBK1
T14464 29324-29329 Protein denotes TRAF3
T14463 29300-29305 Protein denotes ABIN1
T14462 29288-29295 Protein denotes TAX1BP1
T14461 29261-29270 Protein denotes ubiquitin
T14460 29089-29093 Protein denotes IRF3
T14459 29079-29084 Protein denotes NF-κB
T14458 29050-29053 Protein denotes A20
T14457 28684-28692 Negative_regulation denotes inhibits
T14456 28684-28692 Negative_regulation denotes inhibits
T14455 28841-28851 Positive_regulation denotes activation
T14454 28841-28851 Positive_regulation denotes activation
T14453 28836-28840 Protein denotes IRF3
T14452 28826-28831 Protein denotes NF-κB
T14451 28795-28799 Protein denotes IFNβ
T14450 28784-28789 Protein denotes MIP-2
T14449 28780-28782 Protein denotes KC
T14448 28774-28778 Protein denotes IL-6
T14447 28769-28772 Protein denotes TNF
T14446 28647-28652 Protein denotes RIG-I
T14445 28342-28350 Positive_regulation denotes enhanced
T14444 28342-28350 Positive_regulation denotes enhanced
T14443 28366-28376 Positive_regulation denotes activation
T14442 28366-28376 Positive_regulation denotes activation
T14441 28392-28397 Protein denotes RIG-I
T14440 28361-28365 Protein denotes IRF3
T14439 28351-28356 Protein denotes NF-κB
T14438 28144-28149 Protein denotes CD11b
T14437 28138-28142 Protein denotes Ly6C
T14436 26750-26755 Protein denotes IL-1β
T14435 26742-26745 Protein denotes TNF
T14434 26736-26740 Protein denotes IL-6
T14433 26684-26689 Protein denotes MIP-2
T14432 26677-26679 Protein denotes KC
T14431 26433-26440 Gene_expression denotes express
T14430 26485-26496 Protein denotes type I IFNs
T14429 26165-26174 Gene_expression denotes producers
T14428 26178-26189 Protein denotes type I IFNs
T14427 25474-25484 Gene_expression denotes expression
T14426 25470-25473 Protein denotes A20
T11296 24478-24488 Negative_regulation denotes deficiency
T11295 24474-24477 Protein denotes A20
T11294 24043-24052 Positive_regulation denotes increased
T11293 24043-24052 Positive_regulation denotes increased
T11292 24043-24052 Positive_regulation denotes increased
T11291 23910-23916 Gene_expression denotes levels
T11290 23910-23916 Gene_expression denotes levels
T11289 23910-23916 Gene_expression denotes levels
T11288 23964-23969 Protein denotes IL-1β
T11287 23956-23959 Protein denotes TNF
T11286 23940-23954 Protein denotes cytokines IL-6
T11285 23689-23699 Gene_expression denotes production
T11284 23689-23699 Gene_expression denotes production
T11283 23683-23688 Protein denotes MIP-2
T11282 23676-23678 Protein denotes KC
T11281 22326-22328 Protein denotes HA
T11280 22311-22324 Protein denotes hemagglutinin
T11279 22073-22080 Regulation denotes altered
T11278 22033-22043 Gene_expression denotes expression
T11277 22028-22032 Protein denotes IFNγ
T11276 21999-22007 Protein denotes IFNγ CD8
T11275 21991-21994 Protein denotes GrB
T11274 21808-21812 Protein denotes CD8+
T11273 21689-21699 Gene_expression denotes expressing
T11272 21689-21699 Gene_expression denotes expressing
T11271 21689-21699 Gene_expression denotes expressing
T11270 21559-21569 Gene_expression denotes expression
T11269 21700-21704 Protein denotes CD8+
T11268 21684-21688 Protein denotes IFNγ
T11267 21675-21678 Protein denotes GrB
T11266 21648-21673 Protein denotes virus specific Granzyme B
T11265 21631-21634 Protein denotes CD8
T11264 21555-21558 Protein denotes A20
T11263 21502-21506 Protein denotes CD8+
T11262 21274-21279 Protein denotes CD11b
T11261 21267-21269 Protein denotes F4
T11260 21260-21265 Protein denotes CD11c
T11259 20975-20983 Positive_regulation denotes increase
T11258 20975-20983 Positive_regulation denotes increase
T11257 21011-21022 Positive_regulation denotes recruitment
T8451 17611-17621 Positive_regulation denotes activation
T8450 17611-17621 Positive_regulation denotes activation
T8449 17606-17610 Protein denotes IRF3
T8448 17596-17601 Protein denotes NF-κB
T8447 17421-17424 Protein denotes A20
T8446 17118-17127 Localization denotes secretion
T8445 17118-17127 Localization denotes secretion
T8444 17118-17127 Localization denotes secretion
T8443 17103-17113 Gene_expression denotes Expression
T8442 17103-17113 Gene_expression denotes Expression
T8441 17103-17113 Gene_expression denotes Expression
T8440 17103-17113 Gene_expression denotes Expression
T8439 17103-17113 Gene_expression denotes Expression
T8438 17103-17113 Gene_expression denotes Expression
T8437 17103-17113 Gene_expression denotes Expression
T8436 17103-17113 Gene_expression denotes Expression
T8435 17245-17250 Protein denotes cxcl1
T8434 17241-17243 Protein denotes KC
T8433 17231-17235 Protein denotes ccl2
T8432 17213-17229 Protein denotes chemokines MCP-1
T8431 17199-17204 Protein denotes IFNα4
T8430 17179-17194 Protein denotes type-I IFN IFNβ
T8429 17170-17173 Protein denotes TNF
T8428 17151-17165 Protein denotes cytokines IL-6
T8427 15814-15818 Protein denotes IFNβ
T8426 15806-15809 Protein denotes TNF
T8425 15595-15603 Positive_regulation denotes enhanced
T8424 15595-15603 Positive_regulation denotes enhanced
T8423 15604-15614 Gene_expression denotes expression
T8422 15604-15614 Gene_expression denotes expression
T8421 15627-15631 Protein denotes IFNβ
T8420 15618-15622 Protein denotes IL-6
T8419 15469-15476 Positive_regulation denotes induced
T8418 15440-15448 Protein denotes A20 mRNA
T8417 15297-15300 Protein denotes A20
T8416 15251-15261 Gene_expression denotes expression
T8415 15209-15212 Protein denotes A20
T7132 15173-15183 Positive_regulation denotes activation
T7131 15173-15183 Positive_regulation denotes activation
T7130 15168-15172 Protein denotes IRF3
T7129 15158-15163 Protein denotes NF-κB
T7128 14832-14840 Positive_regulation denotes enhanced
T7127 14832-14840 Positive_regulation denotes enhanced
T7126 14915-14924 Positive_regulation denotes increased
T7125 14915-14924 Positive_regulation denotes increased
T7124 14915-14924 Positive_regulation denotes increased
T7123 14906-14914 Localization denotes secreted
T7122 14906-14914 Localization denotes secreted
T7121 14906-14914 Localization denotes secreted
T7120 14841-14851 Positive_regulation denotes activation
T7119 14841-14851 Positive_regulation denotes activation
T7118 14950-14954 Protein denotes IFNβ
T7117 14942-14945 Protein denotes TNF
T7116 14936-14940 Protein denotes IL-6
T7115 14865-14869 Protein denotes IRF3
T7114 14855-14860 Protein denotes NF-κB
T7113 14783-14790 Regulation denotes control
T7112 14783-14790 Regulation denotes control
T7111 14723-14731 Regulation denotes controls
T7110 14723-14731 Regulation denotes controls
T7109 14795-14805 Gene_expression denotes expression
T7108 14736-14746 Gene_expression denotes expression
T7107 14736-14746 Gene_expression denotes expression
T7106 14809-14813 Protein denotes IFNβ
T7105 14778-14782 Protein denotes IRF3
T7104 14768-14773 Protein denotes NF-κB
T7103 14759-14762 Protein denotes TNF
T7102 14750-14754 Protein denotes IL-6
T7101 14717-14722 Protein denotes NF-κB
T7100 14595-14608 Localization denotes translocation
T7099 14587-14594 Entity denotes nuclear
T7098 14582-14586 Protein denotes IRF3
T7097 14577-14580 Protein denotes p65
T7096 14455-14470 Phosphorylation denotes phosphorylation
T7095 14450-14454 Protein denotes IRF3
T7094 14350-14357 Entity denotes nucleus
T7093 14162-14171 Positive_regulation denotes activated
T7092 14266-14270 Protein denotes TBK1
T7091 14249-14265 Protein denotes IKK-like kinases
T7090 14142-14146 Protein denotes IRF3
T7089 14008-14016 Positive_regulation denotes enhanced
T7088 14008-14016 Positive_regulation denotes enhanced
T7085 13957-13964 Entity denotes nuclear
T7084 13993-13995 Protein denotes κB
T7083 13986-13992 Protein denotes p65 NF
T7082 13871-13880 Positive_regulation denotes increased
T7081 13871-13880 Positive_regulation denotes increased
T7080 13844-13854 Positive_regulation denotes activation
T7079 13829-13837 Positive_regulation denotes enhanced
T7078 13911-13922 Protein_catabolism denotes degradation
T7077 13881-13896 Phosphorylation denotes phosphorylation
T7076 13844-13854 Positive_regulation denotes activation
T7075 13926-13930 Protein denotes IκBα
T7074 13838-13843 Protein denotes NF-κB
T7073 13509-13516 Positive_regulation denotes induced
T7072 13527-13537 Gene_expression denotes expression
T7071 13541-13544 Protein denotes A20
T7070 13372-13378 Positive_regulation denotes induce
T7069 13372-13378 Positive_regulation denotes induce
T7068 13421-13431 Positive_regulation denotes activation
T7067 13421-13431 Positive_regulation denotes activation
T7066 13416-13420 Protein denotes IRF3
T7065 13391-13411 Protein denotes TLR3 dependent NF-κB
T7064 13279-13287 Positive_regulation denotes activate
T7063 13086-13095 Positive_regulation denotes stimulate
T7062 13288-13293 Protein denotes RIG-I
T7061 13100-13114 Protein denotes RIG-I receptor
T7060 12931-12938 Regulation denotes control
T7059 12898-12908 Gene_expression denotes expressing
T7058 12946-12965 Protein denotes lysozyme M promoter
T7057 12909-12924 Protein denotes Cre recombinase
T7056 12781-12791 Protein denotes A20 allele
T7055 11031-11038 Negative_regulation denotes inhibit
T7054 11031-11038 Negative_regulation denotes inhibit
T7053 11070-11080 Positive_regulation denotes activation
T7052 11070-11080 Positive_regulation denotes activation
T7051 11063-11069 Protein denotes IRF3/7
T7050 11053-11058 Protein denotes NF-κB
T7049 10915-10924 Negative_regulation denotes prevented
T7048 10869-10875 Regulation denotes effect
T7047 10869-10875 Regulation denotes effect
T7046 10944-10954 Positive_regulation denotes activation
T7045 10894-10904 Positive_regulation denotes activation
T7044 10894-10904 Positive_regulation denotes activation
T7043 10939-10943 Protein denotes IRF7
T7042 10906-10909 Protein denotes A20
T7041 10889-10893 Protein denotes IRF3
T7040 10879-10884 Protein denotes NF-κB
T7039 10713-10723 Positive_regulation denotes activation
T7038 10666-10679 Gene_expression denotes co-expression
T7037 10837-10841 Protein denotes IRF7
T7036 10698-10712 Protein denotes IFNα4 promoter
T7035 10661-10665 Protein denotes IRF7
T7034 10490-10500 Gene_expression denotes expression
T7033 10453-10464 Positive_regulation denotes transfected
T7032 10453-10464 Positive_regulation denotes transfected
T7031 10453-10464 Gene_expression denotes transfected
T7030 10453-10464 Gene_expression denotes transfected
T7029 10581-10606 Protein denotes IFNα4 luciferase reporter
T7028 10567-10571 Protein denotes IRF7
T7027 10556-10559 Protein denotes A20
T7026 10485-10489 Protein denotes IRF7
T7025 10423-10427 Protein denotes IRF7
T7024 10330-10341 Positive_regulation denotes upregulated
T7023 10366-10376 Positive_regulation denotes activation
T7022 10261-10270 Gene_expression denotes expressed
T7021 10261-10270 Gene_expression denotes expressed
T7020 10361-10365 Protein denotes IRF3
T7019 10298-10310 Protein denotes IRF7 protein
T7018 10239-10243 Protein denotes IRF7
T7017 10233-10237 Protein denotes IRF3
T7016 10200-10208 Negative_regulation denotes inhibits
T7015 10214-10224 Positive_regulation denotes activation
T7014 10209-10213 Protein denotes IRF7
T7013 9968-9975 Positive_regulation denotes induced
T7012 9865-9879 Positive_regulation denotes overexpression
T7011 9865-9879 Gene_expression denotes overexpression
T7010 9932-9942 Protein denotes luciferase
T7009 9917-9921 Protein denotes IRF3
T7008 9906-9911 Protein denotes NF-κB
T7007 9861-9864 Protein denotes A20
T7006 9767-9776 Regulation denotes regulates
T7005 9767-9776 Regulation denotes regulates
T7004 9792-9802 Positive_regulation denotes activation
T7003 9792-9802 Positive_regulation denotes activation
T7002 9742-9751 Gene_expression denotes expressed
T7001 9808-9813 Protein denotes RIG-I
T7000 9787-9791 Protein denotes IRF3
T6999 9777-9782 Protein denotes NF-κB
T6998 9752-9755 Protein denotes A20
T6997 9588-9595 Positive_regulation denotes promote
T6996 9588-9595 Positive_regulation denotes promote
T6995 9588-9595 Positive_regulation denotes promote
T6994 9512-9519 Positive_regulation denotes induces
T6993 9512-9519 Positive_regulation denotes induces
T6992 9512-9519 Positive_regulation denotes induces
T6991 9600-9610 Gene_expression denotes expression
T6990 9524-9534 Positive_regulation denotes activation
T6989 9524-9534 Positive_regulation denotes activation
T6988 9524-9534 Positive_regulation denotes activation
T6987 9644-9655 Protein denotes type I IFNs
T6986 9554-9580 Protein denotes IRF7 transcription factors
T6985 9545-9549 Protein denotes IRF3
T6984 9538-9543 Protein denotes NF-κB
T6983 9496-9501 Protein denotes RIG-I
T6982 9485-9495 Positive_regulation denotes activation
T6981 9456-9469 Positive_regulation denotes RIG-I-induced
T6980 9447-9455 Negative_regulation denotes inhibits
T6979 9485-9495 Positive_regulation denotes activation
T6978 9480-9484 Protein denotes IRF3
T6977 9470-9475 Protein denotes NF-κB
T3988 9369-9372 Protein denotes A20
T3987 8815-8818 Protein denotes A20
T3986 8581-8584 Protein denotes A20
T3985 8527-8532 Protein denotes IRF-3
T3984 8517-8522 Protein denotes NF-κB
T3983 8491-8495 Protein denotes TLR3
T3982 8463-8466 Protein denotes A20
T3981 8270-8273 Protein denotes A20
T3980 8071-8080 Protein denotes A20 locus
T3979 7884-7887 Protein denotes A20
T3978 7750-7753 Protein denotes A20
T3977 7573-7576 Protein denotes A20
T3976 7490-7504 Protein denotes TNF receptor I
T3975 7444-7447 Protein denotes A20
T3974 7278-7294 Protein denotes ubiquitin ligase
T3973 7275-7277 Protein denotes E3
T3972 7214-7217 Protein denotes A20
T3971 7172-7189 Protein denotes OTU-domain family
T3970 7130-7139 Protein denotes ubiquitin
T3969 7120-7123 Protein denotes A20
T3968 7062-7067 Protein denotes RBCK1
T3967 6993-7019 Protein denotes IRF7 transcription factors
T3966 6984-6988 Protein denotes IRF3
T3965 6943-6976 Protein denotes K48-specific polyubiquitin chains
T3964 6852-6863 Protein_catabolism denotes degradation
T3963 6852-6863 Protein_catabolism denotes degradation
T3962 6822-6827 Protein denotes TRAF3
T3961 6728-6758 Protein denotes K48-specific ubiquitin ligases
T3960 6652-6665 Protein denotes polyubiquitin
T3959 6388-6395 Positive_regulation denotes mediate
T3958 6388-6395 Positive_regulation denotes mediate
T3957 6424-6434 Positive_regulation denotes activation
T3956 6424-6434 Positive_regulation denotes activation
T3946 6163-6193 Protein denotes K63-specific ubiquitin ligases
T3945 6122-6127 Protein denotes RIG-I
T3944 6047-6056 Protein denotes ubiquitin
T3943 6011-6015 Protein denotes MAVS
T3942 5759-5768 Binding denotes associate
T3941 5724-5731 Binding denotes binding
T3940 5724-5731 Binding denotes binding
T3939 5724-5731 Binding denotes binding
T3938 5778-5789 Protein denotes CARD domain
T3937 5753-5758 Protein denotes RIG-I
T3936 5737-5749 Protein denotes CARD domains
T3935 5609-5628 Protein denotes DExD/H box helicase
T3934 5335-5344 Negative_regulation denotes deficient
T3933 5330-5334 Protein denotes TLR3
T3932 5213-5218 Protein denotes RIG-I
T3931 5003-5008 Protein denotes RIG-I
T3930 4994-4998 Protein denotes TLR3
T3929 4139-4148 Gene_expression denotes producing
T3928 4128-4138 Protein denotes type I IFN
T3927 4011-4021 Gene_expression denotes containing
T3926 4011-4021 Gene_expression denotes containing
T3925 4054-4059 Protein denotes IFI16
T3924 3998-4010 Protein denotes PYHIN domain
T3923 3976-3980 Protein denotes TLR9
T3922 3744-3748 Protein denotes RLRs
T3921 3773-3777 Protein denotes NLRs
T3920 3880-3884 Protein denotes MDA5
T3919 3873-3878 Protein denotes RIG-I
T3918 3867-3871 Protein denotes TLR3
T3917 3837-3841 Protein denotes Nod2
T3916 3831-3835 Protein denotes TLR8
T3915 3825-3829 Protein denotes TLR7
T3914 3753-3771 Protein denotes Nod-like receptors
T3913 3722-3742 Protein denotes RIG-I-like receptors
T3912 3687-3691 Protein denotes TLRs
T3911 3656-3685 Protein denotes Endosomal Toll-like receptors
T3910 3197-3204 Positive_regulation denotes induces
T3909 3197-3204 Positive_regulation denotes induces
T3908 3197-3204 Positive_regulation denotes induces
T3907 3197-3204 Positive_regulation denotes induces
T3906 3197-3204 Positive_regulation denotes induces
T3905 3197-3204 Positive_regulation denotes induces
T3904 3197-3204 Positive_regulation denotes induces
T3903 3209-3219 Gene_expression denotes production
T3902 3209-3219 Gene_expression denotes production
T3901 3209-3219 Gene_expression denotes production
T3900 3209-3219 Gene_expression denotes production
T3899 3209-3219 Gene_expression denotes production
T3898 3209-3219 Gene_expression denotes production
T3897 3209-3219 Gene_expression denotes production
T3896 3461-3469 Protein denotes IRF7 [1]
T3895 3452-3456 Protein denotes IRF3
T3894 3446-3450 Protein denotes AP-1
T3893 3439-3444 Protein denotes NF-κB
T3892 3329-3334 Protein denotes IFN-β
T3891 3318-3323 Protein denotes IFN-α
T3890 3304-3316 Protein denotes interferon-α
T3889 3284-3302 Protein denotes type I interferons
T3888 3274-3278 Protein denotes IL-1
T3887 3265-3269 Protein denotes IL-6
T3886 3260-3263 Protein denotes TNF
T3885 3102-3105 Protein denotes PRR
T3955 6440-6445 Protein denotes RIG-I
T3954 6419-6423 Protein denotes IRF3
T3953 6409-6414 Protein denotes NF-κB
T3952 6330-6347 Protein denotes ubiquitin ligases
T3951 6286-6296 Positive_regulation denotes activation
T3950 6272-6279 Gene_expression denotes promote
T3949 6272-6279 Gene_expression denotes promote
T3948 6280-6285 Protein denotes RIG-I
T3947 6195-6198 Protein denotes E3s
T583 1512-1522 Negative_regulation denotes inhibition
T582 1526-1529 Protein denotes A20
T581 1026-1035 Positive_regulation denotes increased
T580 973-981 Positive_regulation denotes enhanced
T579 973-981 Positive_regulation denotes enhanced
T578 1036-1046 Gene_expression denotes production
T577 997-1007 Positive_regulation denotes activation
T576 997-1007 Positive_regulation denotes activation
T575 1092-1109 Protein denotes type I interferon
T574 992-996 Protein denotes IRF3
T573 982-987 Protein denotes NF-κB
T572 773-777 Gene_expression denotes role
T571 773-777 Gene_expression denotes role
T570 811-814 Protein denotes A20
T569 785-810 Protein denotes ubiquitin-editing protein
T568 473-480 Positive_regulation denotes induces
T567 485-495 Gene_expression denotes production
T566 539-549 Protein denotes interferon
T565 463-468 Protein denotes RIG-I
T17733 38571-38605 Protein denotes anti-phospho-IκBα (Cell Signaling)
T17732 38549-38566 Protein denotes anti-phospho-IRF3
T17731 38496-38510 Protein denotes anti-histon H1
T17730 38482-38490 Protein denotes anti-p65
T17729 38471-38480 Protein denotes anti-IκBα
T17728 38461-38469 Protein denotes anti-A20
T17727 38215-38265 Protein denotes mM EGTA supplemented with protease and phosphatase
T17726 37864-37914 Protein denotes mM EGTA supplemented with protease and phosphatase
T17725 37701-37711 Negative_regulation denotes inhibitors
T17724 37676-37700 Protein denotes protease and phosphatase
T15248 33302-33309 Negative_regulation denotes lacking
T15247 33288-33298 Gene_expression denotes expressing
T15246 33314-33332 Protein denotes LysM-Cre transgene
T15245 33254-33261 Protein denotes C57Bl/6
T15244 33206-33209 Protein denotes Cre
T15243 33201-33205 Protein denotes LysM
T15242 32763-32766 Protein denotes Cre
T15241 32758-32762 Protein denotes LysM
T11256 21011-21022 Positive_regulation denotes recruitment
T11255 21004-21008 Protein denotes Ly6C
T11254 20997-21002 Protein denotes CD11b
T11253 20747-20752 Protein denotes Ly6C+
T11252 20740-20745 Protein denotes CD11b
T11251 20680-20685 Protein denotes MIP-2
T11250 20673-20675 Protein denotes KC
T11249 20427-20431 Protein denotes IL-8
T11248 20396-20398 Protein denotes KC
T11247 20311-20319 Positive_regulation denotes increase
T11246 20337-20347 Gene_expression denotes production
T11245 20332-20336 Protein denotes IFNα
T11244 20323-20328 Protein denotes MCP-1
T11243 20069-20073 Protein denotes IL-6
T11242 19807-19817 Negative_regulation denotes deficiency
T11241 19803-19806 Protein denotes A20
T11240 17709-17713 Regulation denotes role
T11239 17721-17731 Gene_expression denotes expression
T11238 17717-17720 Protein denotes A20
T11237 17628-17638 Negative_regulation denotes deficiency
T11236 17624-17627 Protein denotes A20
T3884 3071-3100 Protein denotes pattern recognition receptors
T7087 13965-13978 Localization denotes translocation
T7086 13965-13978 Localization denotes translocation
T15644 33517-33521 Protein denotes MDCK
R460 T570 T572 themeOf A20,role
R461 T573 T576 themeOf NF-κB,activation
R462 T574 T577 themeOf IRF3,activation
R463 T575 T578 themeOf type I interferon,production
R464 T576 T579 themeOf activation,enhanced
R465 T577 T580 themeOf activation,enhanced
R466 T578 T581 themeOf production,increased
R467 T582 T583 themeOf A20,inhibition
R3002 T3886 T3897 themeOf TNF,production
R3003 T3887 T3898 themeOf IL-6,production
R3004 T3888 T3899 themeOf IL-1,production
R3005 T3889 T3900 themeOf type I interferons,production
R3006 T3890 T3901 themeOf interferon-α,production
R3007 T3891 T3902 themeOf IFN-α,production
R3008 T3892 T3903 themeOf IFN-β,production
R3009 T3928 T3929 themeOf type I IFN,producing
R3010 T3897 T3904 themeOf production,induces
R3011 T3933 T3934 themeOf TLR3,deficient
R3012 T3898 T3905 themeOf production,induces
R3013 T3936 T3939 themeOf CARD domains,binding
R3014 T3936 T3941 themeOf CARD domains,binding
R3015 T3937 T3940 themeOf RIG-I,binding
R3016 T3937 T3941 themeOf RIG-I,binding
R3017 T3937 T3942 themeOf RIG-I,associate
R3018 T3938 T3942 themeOf CARD domain,associate
R3019 T3899 T3906 themeOf production,induces
R3020 T3900 T3907 themeOf production,induces
R3021 T3901 T3908 themeOf production,induces
R3022 T3946 T3949 themeOf K63-specific ubiquitin ligases,promote
R3023 T3947 T3950 themeOf E3s,promote
R3024 T3902 T3909 themeOf production,induces
R3025 T3948 T3951 themeOf RIG-I,activation
R3026 T3903 T3910 themeOf production,induces
R3027 T3924 T3926 themeOf PYHIN domain,containing
R3028 T3953 T3956 themeOf NF-κB,activation
R3029 T3954 T3957 themeOf IRF3,activation
R3030 T3956 T3958 themeOf activation,mediate
R3031 T3957 T3959 themeOf activation,mediate
R3032 T3958 T3952 Cause mediate,ubiquitin ligases
R3033 T3959 T3952 Cause mediate,ubiquitin ligases
R3034 T3961 T3963 themeOf K48-specific ubiquitin ligases,degradation
R3035 T3962 T3964 themeOf TRAF3,degradation
R3036 T3925 T3927 themeOf IFI16,containing
R5042 T6977 T6979 themeOf NF-κB,activation
R5045 T6979 T6980 themeOf activation,inhibits
R5046 T6979 T6981 themeOf activation,RIG-I-induced
R5047 T6981 T6982 themeOf RIG-I-induced,activation
R5050 T6984 T6988 themeOf NF-κB,activation
R5052 T6985 T6989 themeOf IRF3,activation
R5053 T6986 T6990 themeOf IRF7 transcription factors,activation
R5055 T6987 T6991 themeOf type I IFNs,expression
R5056 T6988 T6992 themeOf activation,induces
R5058 T6989 T6993 themeOf activation,induces
R5059 T6990 T6994 themeOf activation,induces
R5060 T6991 T6995 themeOf expression,promote
R5061 T6991 T6996 themeOf expression,promote
R5062 T6991 T6997 themeOf expression,promote
R5065 T6995 T6984 Cause promote,NF-κB
R5067 T6996 T6985 Cause promote,IRF3
R5068 T6997 T6986 Cause promote,IRF7 transcription factors
R5069 T6998 T7002 themeOf A20,expressed
R5070 T6999 T7003 themeOf NF-κB,activation
R5072 T7000 T7004 themeOf IRF3,activation
R5077 T7003 T7005 themeOf activation,regulates
R5078 T7004 T7006 themeOf activation,regulates
R5081 T7007 T7011 themeOf A20,overexpression
R5082 T7010 T7013 themeOf luciferase,induced
R5083 T7011 T7012 themeOf overexpression,overexpression
R5085 T7014 T7015 themeOf IRF7,activation
R5086 T7015 T7016 themeOf activation,inhibits
R5088 T7017 T7021 themeOf IRF3,expressed
R5089 T7018 T7022 themeOf IRF7,expressed
R5091 T7020 T7023 themeOf IRF3,activation
R5092 T7023 T7024 themeOf activation,upregulated
R5094 T7026 T7030 themeOf IRF7,transfected
R5095 T7026 T7034 themeOf IRF7,expression
R5096 T7027 T7031 themeOf A20,transfected
R5098 T7030 T7032 themeOf transfected,transfected
R5099 T7031 T7033 themeOf transfected,transfected
R5101 T7035 T7038 themeOf IRF7,co-expression
R5102 T7036 T7039 themeOf IFNα4 promoter,activation
R5103 T7040 T7044 themeOf NF-κB,activation
R5104 T7086 T7085 ToLoc translocation,nuclear
R5105 T7041 T7045 themeOf IRF3,activation
R5106 T7043 T7046 themeOf IRF7,activation
R5107 T7086 T7088 themeOf translocation,enhanced
R5108 T7044 T7047 themeOf activation,effect
R5109 T7045 T7048 themeOf activation,effect
R5110 T7087 T7085 ToLoc translocation,nuclear
R5111 T7087 T7089 themeOf translocation,enhanced
R5112 T7046 T7049 themeOf activation,prevented
R5113 T7090 T7093 themeOf IRF3,activated
R5114 T7049 T7042 Cause prevented,A20
R5115 T7050 T7052 themeOf NF-κB,activation
R5116 T7051 T7053 themeOf IRF3/7,activation
R5117 T7093 T7092 Cause activated,TBK1
R5118 T7052 T7054 themeOf activation,inhibit
R5119 T7053 T7055 themeOf activation,inhibit
R5120 T7095 T7096 themeOf IRF3,phosphorylation
R5121 T7057 T7059 themeOf Cre recombinase,expressing
R5122 T7059 T7060 themeOf expressing,control
R5123 T7098 T7100 themeOf IRF3,translocation
R5124 T7060 T7058 Cause control,lysozyme M promoter
R5125 T7061 T7063 themeOf RIG-I receptor,stimulate
R5126 T7062 T7064 themeOf RIG-I,activate
R5127 T7100 T7099 ToLoc translocation,nuclear
R5128 T7065 T7067 themeOf TLR3 dependent NF-κB,activation
R5129 T7066 T7068 themeOf IRF3,activation
R5130 T7067 T7069 themeOf activation,induce
R5131 T7102 T7107 themeOf IL-6,expression
R5132 T7068 T7070 themeOf activation,induce
R5133 T7071 T7072 themeOf A20,expression
R5134 T7103 T7108 themeOf TNF,expression
R5135 T7072 T7073 themeOf expression,induced
R5136 T7074 T7076 themeOf NF-κB,activation
R5137 T7106 T7109 themeOf IFNβ,expression
R5138 T7075 T7077 themeOf IκBα,phosphorylation
R5139 T7075 T7078 themeOf IκBα,degradation
R5140 T7076 T7079 themeOf activation,enhanced
R5141 T7077 T7081 themeOf phosphorylation,increased
R5142 T7078 T7082 themeOf degradation,increased
R5143 T7079 T7080 themeOf enhanced,activation
R5144 T7083 T7086 themeOf p65 NF,translocation
R5145 T7107 T7110 themeOf expression,controls
R5146 T7084 T7087 themeOf κB,translocation
R5147 T7108 T7111 themeOf expression,controls
R5148 T7109 T7112 themeOf expression,control
R5149 T7109 T7113 themeOf expression,control
R5150 T7110 T7101 Cause controls,NF-κB
R5151 T7111 T7101 Cause controls,NF-κB
R5152 T7112 T7104 Cause control,NF-κB
R5155 T7113 T7105 Cause control,IRF3
R5158 T7114 T7119 themeOf NF-κB,activation
R5159 T7115 T7120 themeOf IRF3,activation
R5160 T7116 T7121 themeOf IL-6,secreted
R5163 T7116 T7124 themeOf IL-6,increased
R5165 T7117 T7122 themeOf TNF,secreted
R5169 T7117 T7125 themeOf TNF,increased
R5171 T7118 T7123 themeOf IFNβ,secreted
R5178 T7118 T7126 themeOf IFNβ,increased
R5179 T7119 T7127 themeOf activation,enhanced
R5181 T7120 T7128 themeOf activation,enhanced
R5184 T7129 T7131 themeOf NF-κB,activation
R5194 T7130 T7132 themeOf IRF3,activation
R6014 T8415 T8416 themeOf A20,expression
R6015 T8418 T8419 themeOf A20 mRNA,induced
R6016 T8420 T8422 themeOf IL-6,expression
R6017 T8421 T8423 themeOf IFNβ,expression
R6018 T8422 T8424 themeOf expression,enhanced
R6019 T8423 T8425 themeOf expression,enhanced
R6020 T8428 T8436 themeOf cytokines IL-6,Expression
R6021 T8429 T8437 themeOf TNF,Expression
R6022 T8429 T8444 themeOf TNF,secretion
R6023 T8430 T8438 themeOf type-I IFN IFNβ,Expression
R6024 T8431 T8439 themeOf IFNα4,Expression
R6025 T8432 T8440 themeOf chemokines MCP-1,Expression
R6026 T8432 T8445 themeOf chemokines MCP-1,secretion
R6027 T8433 T8441 themeOf ccl2,Expression
R6028 T8434 T8442 themeOf KC,Expression
R6029 T8434 T8446 themeOf KC,secretion
R6030 T8435 T8443 themeOf cxcl1,Expression
R6031 T8448 T8450 themeOf NF-κB,activation
R6032 T8449 T8451 themeOf IRF3,activation
R10868 T14426 T14427 themeOf A20,expression
R10871 T14428 T14429 themeOf type I IFNs,producers
R10874 T14430 T14431 themeOf type I IFNs,express
R10876 T14439 T14442 themeOf NF-κB,activation
R10877 T14440 T14443 themeOf IRF3,activation
R10878 T14442 T14444 themeOf activation,enhanced
R10879 T14443 T14445 themeOf activation,enhanced
R10880 T14452 T14454 themeOf NF-κB,activation
R10883 T14453 T14455 themeOf IRF3,activation
R10885 T14454 T14456 themeOf activation,inhibits
R10886 T14455 T14457 themeOf activation,inhibits
R10887 T14461 T14467 themeOf ubiquitin,binding
R10888 T14463 T14467 themeOf ABIN1,binding
R10891 T14471 T14472 themeOf A20,deficiency
R10894 T14474 T14476 themeOf NF-κB,activation
R10899 T14475 T14477 themeOf IRF3,activation
R10900 T14476 T14478 themeOf activation,mediate
R10902 T14477 T14479 themeOf activation,mediate
R10904 T14483 T14485 themeOf A20,expression
R10906 T14488 T14490 themeOf A20,targeting
R12403 T16445 T16448 themeOf GrB,staining
R12404 T16446 T16449 themeOf IFNγ,staining
R12405 T16450 T16456 themeOf Granzyme B,expressing
R12406 T16451 T16457 themeOf GrB,expressing
R12407 T16452 T16458 themeOf IFNγ,expressing
R12408 T16461 T16463 themeOf CD62lo CD3,expression
R12409 T16462 T16464 themeOf CD8+,expression
R12929 T17093 T17102 themeOf pEF-HA-IRF-7,expression
R12930 T17094 T17103 themeOf NF-κB,expression
R12931 T17095 T17104 themeOf IRF3,expression
R12932 T17096 T17105 themeOf IRF7,expression
R12933 T17097 T17106 themeOf pISRE-luc,expression
R12934 T17098 T17107 themeOf LMBP4011,expression
R12935 T17099 T17108 themeOf pGL3-IFNα4-luc,expression
R12936 T17100 T17109 themeOf pACTbetagal,expression
R12937 T17101 T17110 themeOf LMBP4341,expression
R14342 T19045 T19046 themeOf iScript cDNA,synthesis
R14343 T19047 T19051 themeOf Green I master mix I,using
R14344 T19052 T19053 themeOf HPRT,expressed
R15073 T20072 T20075 themeOf NF-κB,activation
R15074 T20073 T20076 themeOf IRF3,activation
R15075 T20075 T20077 themeOf activation,inhibits
R15076 T20076 T20078 themeOf activation,inhibits
R15077 T20077 T20071 Cause inhibits,A20
R15078 T20078 T20071 Cause inhibits,A20
R15079 T20079 T20084 themeOf NF-κB,transfected
R15080 T20080 T20085 themeOf IRF3,transfected
R15081 T20082 T20086 themeOf IRF7,expressing
R15082 T20083 T20087 themeOf A20,expressing
R15083 T20089 T20091 themeOf IκBα,phosphorylation
R15084 T20089 T20092 themeOf IκBα,degradation
R15085 T20090 T20093 themeOf IRF3,phosphorylation
R15086 T20094 T20095 themeOf anti-IκBα antibody,recognized
R15087 T20096 T20100 themeOf NF-κB,translocation
R15088 T20097 T20101 themeOf p65,translocation
R15089 T20098 T20102 themeOf IRF3,translocation
R15090 T20100 T20099 ToLoc translocation,Nuclear
R15091 T20101 T20099 ToLoc translocation,Nuclear
R15092 T20102 T20099 ToLoc translocation,Nuclear
R15093 T20103 T20105 themeOf p65,expressed
R15094 T20104 T20106 themeOf IRF3,expressed
R15095 T20107 T20113 themeOf IL-6,levels
R15096 T20108 T20114 themeOf TNF,levels
R15097 T20109 T20115 themeOf IFNβ,levels
R15479 T20679 T20682 themeOf IL-6,expression
R15480 T20680 T20683 themeOf IFNβ,expression
R15481 T20681 T20684 themeOf A20 mRNA,expression
R15482 T20687 T20689 themeOf IL-6,expression
R15483 T20688 T20690 themeOf IFNβ mRNA,expression
R15839 T21153 T21154 themeOf A20,deficiency
R16160 T21582 T21583 themeOf A20,deficiency
R456 T562 T564 themeOf Tnfaip3,Deficiency
R457 T566 T567 themeOf interferon,production
R458 T567 T568 themeOf production,induces
R459 T569 T571 themeOf ubiquitin-editing protein,role
R8396 T11236 T11237 themeOf A20,deficiency
R8398 T11238 T11239 themeOf A20,expression
R8399 T11239 T11240 themeOf expression,role
R8401 T11241 T11242 themeOf A20,deficiency
R8402 T11245 T11246 themeOf IFNα,production
R8403 T11246 T11247 themeOf production,increase
R455 T561 T563 themeOf A20,Deficiency
R8406 T11254 T11256 themeOf CD11b,recruitment
R8407 T11255 T11257 themeOf Ly6C,recruitment
R8408 T11256 T11258 themeOf recruitment,increase
R8409 T11257 T11259 themeOf recruitment,increase
R8410 T11264 T11270 themeOf A20,expression
R8412 T11266 T11271 themeOf virus specific Granzyme B,expressing
R8413 T11268 T11272 themeOf IFNγ,expressing
R8415 T11269 T11273 themeOf CD8+,expressing
R8418 T11277 T11278 themeOf IFNγ,expression
R8419 T11278 T11279 themeOf expression,altered
R8421 T11282 T11284 themeOf KC,production
R8422 T11283 T11285 themeOf MIP-2,production
R8423 T11286 T11289 themeOf cytokines IL-6,levels
R8424 T11287 T11290 themeOf TNF,levels
R8426 T11288 T11291 themeOf IL-1β,levels
R8427 T11289 T11292 themeOf levels,increased
R8429 T11290 T11293 themeOf levels,increased
R8430 T11291 T11294 themeOf levels,increased
R8431 T11295 T11296 themeOf A20,deficiency
R11386 T15246 T15247 themeOf LysM-Cre transgene,expressing
R11387 T15246 T15248 themeOf LysM-Cre transgene,lacking
R13503 T17724 T17725 themeOf protease and phosphatase,inhibitors
R14008 T18561 T18566 themeOf MCP-1,Detection
R14009 T18562 T18567 themeOf KC,Detection
R14010 T18563 T18568 themeOf TNF,Detection
R14011 T18564 T18569 themeOf IL-1β,Detection
R14012 T18565 T18570 themeOf IL-6,Detection

testone

Id Subject Object Predicate Lexical cue
T5 5-12 Protein denotes Tnfaip3
T9 14-24 Negative_regulation denotes Deficiency
T11608 29368-29377 Regulation denotes affecting
T21207 25010-25019 Positive_regulation denotes following
T21206 24656-24666 Negative_regulation denotes deficiency
T21205 25084-25088 Protein denotes IFNα
T21204 25075-25079 Protein denotes IL-6
T21203 25068-25073 Protein denotes MCP-1
T21202 25061-25066 Protein denotes MIP-2
T21201 25057-25059 Protein denotes KC
T20767 18971-18981 Negative_regulation denotes deficiency
T20766 19427-19431 Protein denotes IL-6
T20765 19420-19425 Protein denotes MCP-1
T20764 19413-19418 Protein denotes MIP-2
T20763 19409-19411 Protein denotes KC
T20260 16423-16438 Transcription denotes mRNA expression
T20259 16141-16156 Transcription denotes mRNA expression
T20258 16518-16522 Protein denotes IFNβ
T20257 16509-16513 Protein denotes IL-6
T20256 16418-16422 Protein denotes IFNβ
T20255 16409-16413 Protein denotes IL-6
T20254 16257-16261 Protein denotes IFNβ
T20253 16249-16252 Protein denotes TNF
T20252 16128-16132 Protein denotes IFNβ
T20251 16122-16126 Protein denotes IL-6
T19302 11955-11968 Localization denotes translocation
T19301 11947-11954 Entity denotes Nuclear
T19300 11849-11859 Binding denotes recognized
T19299 11753-11768 Phosphorylation denotes phosphorylation
T19298 11731-11742 Protein_catabolism denotes degradation
T19297 11711-11726 Phosphorylation denotes phosphorylation
T19296 11591-11602 Gene_expression denotes transfected
T19295 12335-12339 Protein denotes IFNβ
T19294 12327-12330 Protein denotes TNF
T19293 12310-12314 Protein denotes IL-6
T19292 12229-12233 Protein denotes IFNβ
T19291 12221-12224 Protein denotes TNF
T19290 12215-12219 Protein denotes IL-6
T19289 12116-12120 Protein denotes IRF3
T19288 12108-12111 Protein denotes p65
T19287 11988-11992 Protein denotes IRF3
T19286 11979-11982 Protein denotes p65
T19285 11748-11752 Protein denotes IRF3
T19284 11706-11710 Protein denotes IκBα
T19283 11372-11376 Protein denotes IRF7
T19282 11285-11295 Protein denotes luciferase
T19281 11270-11274 Protein denotes IRF7
T19280 11253-11257 Protein denotes IRF3
T19279 11180-11185 Protein denotes RIG-I
T19278 11149-11153 Protein denotes IRF3
T18643 41332-41341 Gene_expression denotes expressed
T18642 41106-41111 Protein denotes IFNα4
T18641 41037-41042 Protein denotes CXCL1
T18640 40966-40970 Protein denotes CCL2
T18639 40900-40903 Protein denotes A20
T18638 40831-40835 Protein denotes IFNβ
T18637 40759-40763 Protein denotes IL-6
T19099 41391-41400 Gene_expression denotes expressed
T18249 40135-40139 Protein denotes IL-6
T18248 40125-40130 Protein denotes IL-1β
T18247 40120-40123 Protein denotes TNF
T18246 40116-40118 Protein denotes KC
T18245 40109-40114 Protein denotes MCP-1
T18244 39891-39895 Protein denotes IFNβ
T18243 39800-39803 Protein denotes TNF
T18242 39757-39760 Protein denotes TNF
T17807 39523-39527 Protein denotes CD16
T17806 39495-39499 Protein denotes IFNγ
T17805 39474-39478 Protein denotes CD8α
T17804 39436-39440 Protein denotes Ly6G
T17803 39366-39369 Protein denotes CD3
T17802 39321-39331 Protein denotes Granzyme B
T17801 39302-39307 Protein denotes CD62L
T17800 38886-38905 Protein denotes collagenase type IV
T16535 36552-36556 Protein denotes IRF7
T16534 36546-36550 Protein denotes IRF3
T16088 35951-35961 Gene_expression denotes expression
T16087 35471-35481 Gene_expression denotes expressing
T16086 35946-35949 Protein denotes CD8
T16085 35937-35940 Protein denotes CD3
T16084 35876-35879 Protein denotes CD8
T16083 35482-35485 Protein denotes CD8
T16082 35457-35460 Protein denotes GrB
T16081 35445-35455 Protein denotes Granzyme B
T16080 35432-35435 Protein denotes CD8
T16079 35397-35400 Protein denotes GrB
T14991 33302-33309 Negative_regulation denotes lacking
T14990 33288-33298 Gene_expression denotes expressing
T11613 31917-31927 Negative_regulation denotes inhibitors
T11612 30564-30574 Negative_regulation denotes deficiency
T11611 30410-30420 Gene_expression denotes expression
T11610 29718-29728 Negative_regulation denotes deficiency
T11609 29616-29630 Negative_regulation denotes ubiquitination
T11607 29357-29367 Negative_regulation denotes negatively
T11606 29312-29319 Negative_regulation denotes disrupt
T11605 28841-28851 Positive_regulation denotes activation
T11604 28684-28692 Negative_regulation denotes inhibits
T11603 28319-28328 Negative_regulation denotes deficient
T11602 28060-28070 Negative_regulation denotes deficiency
T11601 27428-27437 Gene_expression denotes expressed
T11600 27380-27389 Negative_regulation denotes deficient
T11599 27337-27347 Gene_expression denotes production
T11598 27207-27214 Negative_regulation denotes absence
T11597 25474-25484 Gene_expression denotes expression
T11596 30465-30470 Protein denotes RIG-I
T11595 30172-30177 Protein denotes IRF-3
T11594 30143-30148 Protein denotes RIG-I
T11593 30055-30059 Protein denotes CYLD
T11592 29853-29857 Protein denotes IRF3
T11591 29643-29647 Protein denotes IKKε
T11590 29634-29638 Protein denotes TBK1
T11589 29527-29532 Protein denotes RIG-I
T11588 29449-29453 Protein denotes IRF3
T11587 29413-29417 Protein denotes IKKε
T11586 29404-29408 Protein denotes TBK1
T11585 29300-29305 Protein denotes ABIN1
T11584 29089-29093 Protein denotes IRF3
T11583 28836-28840 Protein denotes IRF3
T11582 28795-28799 Protein denotes IFNβ
T11581 28784-28789 Protein denotes MIP-2
T11580 28780-28782 Protein denotes KC
T11579 28774-28778 Protein denotes IL-6
T11578 28769-28772 Protein denotes TNF
T11577 28647-28652 Protein denotes RIG-I
T11576 28448-28453 Protein denotes RIG-I
T11575 28392-28397 Protein denotes RIG-I
T11574 28361-28365 Protein denotes IRF3
T11573 27331-27336 Protein denotes MCP-1
T11572 27169-27174 Protein denotes MCP-1
T11571 26750-26755 Protein denotes IL-1β
T11570 26742-26745 Protein denotes TNF
T11569 26736-26740 Protein denotes IL-6
T11568 26684-26689 Protein denotes MIP-2
T11567 26677-26679 Protein denotes KC
T8641 24478-24488 Negative_regulation denotes deficiency
T8640 24173-24182 Positive_regulation denotes increased
T8639 24154-24164 Gene_expression denotes production
T8638 24043-24052 Positive_regulation denotes increased
T8637 23704-23712 Positive_regulation denotes stronger
T8636 23689-23699 Gene_expression denotes production
T8635 22553-22563 Gene_expression denotes expression
T8634 22537-22545 Regulation denotes affected
T8633 22234-22238 Negative_regulation denotes loss
T8632 22088-22095 Negative_regulation denotes absence
T8631 22073-22080 Regulation denotes altered
T8630 22033-22043 Gene_expression denotes expression
T8629 21689-21699 Gene_expression denotes expressing
T8628 21559-21569 Gene_expression denotes expression
T8627 21154-21164 Gene_expression denotes expression
T8626 20666-20672 Positive_regulation denotes higher
T8625 20337-20347 Gene_expression denotes production
T8624 20311-20319 Positive_regulation denotes increase
T8623 20093-20099 Positive_regulation denotes higher
T8622 19807-19817 Negative_regulation denotes deficiency
T8621 18785-18789 Negative_regulation denotes loss
T8620 18007-18011 Negative_regulation denotes loss
T8619 17721-17731 Gene_expression denotes expression
T8618 17709-17713 Regulation denotes role
T8617 17628-17638 Negative_regulation denotes deficiency
T8616 24148-24153 Protein denotes MCP-1
T8615 23964-23969 Protein denotes IL-1β
T8614 23956-23959 Protein denotes TNF
T8613 23950-23954 Protein denotes IL-6
T8612 23683-23688 Protein denotes MIP-2
T8611 23676-23678 Protein denotes KC
T8610 21991-21994 Protein denotes GrB
T8609 21675-21678 Protein denotes GrB
T8608 21663-21673 Protein denotes Granzyme B
T8607 21267-21272 Protein denotes F4/80
T8606 21168-21173 Protein denotes MCP-1
T8605 20759-20764 Protein denotes F4/80
T8604 20680-20685 Protein denotes MIP-2
T8603 20673-20675 Protein denotes KC
T8602 20507-20512 Protein denotes MCP-1
T8601 20457-20462 Protein denotes MIP-2
T8600 20427-20431 Protein denotes IL-8
T8599 20396-20398 Protein denotes KC
T8598 20323-20328 Protein denotes MCP-1
T8597 20069-20073 Protein denotes IL-6
T8596 20040-20045 Protein denotes MIP-2
T8595 20033-20035 Protein denotes KC
T7659 17299-17306 Negative_regulation denotes lacking
T7658 17118-17127 Localization denotes secretion
T7657 17103-17113 Gene_expression denotes Expression
T7656 15604-15614 Gene_expression denotes expression
T7655 15595-15603 Positive_regulation denotes enhanced
T7654 15511-15520 Negative_regulation denotes deficient
T7653 15469-15476 Positive_regulation denotes induced
T7652 15391-15400 Negative_regulation denotes deficient
T7651 17606-17610 Protein denotes IRF3
T7650 17582-17587 Protein denotes RIG-I
T7649 17245-17250 Protein denotes cxcl1
T7648 17241-17243 Protein denotes KC
T7647 17231-17235 Protein denotes ccl2
T7646 17224-17229 Protein denotes MCP-1
T7645 17199-17204 Protein denotes IFNα4
T7644 17190-17194 Protein denotes IFNβ
T7643 17170-17173 Protein denotes TNF
T7642 17161-17165 Protein denotes IL-6
T7641 15814-15818 Protein denotes IFNβ
T7640 15806-15809 Protein denotes TNF
T7639 15627-15631 Protein denotes IFNβ
T7638 15618-15622 Protein denotes IL-6
T4571 14915-14924 Positive_regulation denotes increased
T4570 14906-14914 Localization denotes secreted
T4569 14795-14805 Gene_expression denotes expression
T4568 14783-14790 Regulation denotes control
T4567 14736-14746 Gene_expression denotes expression
T4566 14723-14731 Regulation denotes controls
T4565 14661-14670 Negative_regulation denotes deficient
T4564 14595-14608 Localization denotes translocation
T4563 14587-14594 Entity denotes nuclear
T4562 14455-14470 Phosphorylation denotes phosphorylation
T4561 14419-14433 Phosphorylation denotes phosphorylated
T4560 14350-14357 Entity denotes nucleus
T4559 14301-14313 Binding denotes dimerization
T4558 14226-14241 Entity denotes serine residues
T4557 14177-14192 Phosphorylation denotes phosphorylation
T4556 14030-14041 Gene_expression denotes transfected
T4555 14008-14016 Positive_regulation denotes enhanced
T4554 13965-13978 Localization denotes translocation
T4553 13957-13964 Entity denotes nuclear
T4552 13911-13922 Protein_catabolism denotes degradation
T4551 13881-13896 Phosphorylation denotes phosphorylation
T4550 13871-13880 Positive_regulation denotes increased
T4549 13806-13815 Negative_regulation denotes deficient
T4548 13527-13537 Gene_expression denotes expression
T4547 13509-13516 Positive_regulation denotes induced
T4546 13372-13378 Positive_regulation denotes induce
T4545 13270-13274 Binding denotes bind
T4544 12898-12908 Gene_expression denotes expressing
T4543 12611-12620 Negative_regulation denotes deficient
T4542 12488-12497 Gene_expression denotes expressed
T4541 11070-11080 Positive_regulation denotes activation
T4540 10944-10954 Positive_regulation denotes activation
T4539 10931-10938 Positive_regulation denotes induced
T4538 10915-10924 Negative_regulation denotes prevented
T4537 10794-10804 Gene_expression denotes expression
T4536 10669-10679 Gene_expression denotes expression
T4535 10632-10642 Gene_expression denotes expression
T4534 10490-10500 Gene_expression denotes expression
T4533 10453-10464 Gene_expression denotes transfected
T4532 10406-10412 Regulation denotes effect
T4531 10330-10341 Positive_regulation denotes upregulated
T4530 10261-10270 Gene_expression denotes expressed
T4529 10200-10208 Negative_regulation denotes inhibits
T4528 9968-9975 Positive_regulation denotes induced
T4527 9957-9967 Positive_regulation denotes activation
T4526 9922-9931 Regulation denotes dependent
T4525 9897-9905 Negative_regulation denotes prevents
T4524 9865-9879 Positive_regulation denotes overexpression
T4523 9742-9751 Gene_expression denotes expressed
T4522 15168-15172 Protein denotes IRF3
T4521 15144-15149 Protein denotes RIG-I
T4520 14950-14954 Protein denotes IFNβ
T4519 14942-14945 Protein denotes TNF
T4518 14936-14940 Protein denotes IL-6
T4517 14865-14869 Protein denotes IRF3
T4516 14809-14813 Protein denotes IFNβ
T4515 14778-14782 Protein denotes IRF3
T4514 14759-14762 Protein denotes TNF
T4513 14750-14754 Protein denotes IL-6
T4512 14582-14586 Protein denotes IRF3
T4511 14577-14580 Protein denotes p65
T4510 14450-14454 Protein denotes IRF3
T4509 14275-14279 Protein denotes IKKε
T4508 14266-14270 Protein denotes TBK1
T4507 14142-14146 Protein denotes IRF3
T4506 13986-13989 Protein denotes p65
T4505 13926-13930 Protein denotes IκBα
T4504 13416-13420 Protein denotes IRF3
T4503 13391-13395 Protein denotes TLR3
T4502 13306-13310 Protein denotes MDA5
T4501 13288-13293 Protein denotes RIG-I
T4500 13100-13105 Protein denotes RIG-I
T4499 12505-12510 Protein denotes RIG-I
T4498 11068-11069 Protein denotes 7
T4497 11063-11067 Protein denotes IRF3
T4496 11039-11044 Protein denotes RIG-I
T4495 10939-10943 Protein denotes IRF7
T4494 10925-10930 Protein denotes RIG-I
T4493 10889-10893 Protein denotes IRF3
T4492 10837-10841 Protein denotes IRF7
T4491 10661-10665 Protein denotes IRF7
T4490 10587-10597 Protein denotes luciferase
T4489 10567-10571 Protein denotes IRF7
T4488 10485-10489 Protein denotes IRF7
T4487 10423-10427 Protein denotes IRF7
T4486 10361-10365 Protein denotes IRF3
T4485 10298-10302 Protein denotes IRF7
T4484 10239-10243 Protein denotes IRF7
T4483 10233-10237 Protein denotes IRF3
T4482 10209-10213 Protein denotes IRF7
T4481 10104-10109 Protein denotes RIG-I
T4480 10035-10040 Protein denotes RIG-I
T4479 9997-10031 Protein denotes truncated constitutive active form
T4478 9932-9942 Protein denotes luciferase
T4477 9917-9921 Protein denotes IRF3
T4476 9808-9813 Protein denotes RIG-I
T4475 9787-9791 Protein denotes IRF3
T4474 9554-9558 Protein denotes IRF7
T4473 9545-9549 Protein denotes IRF3
T4472 9496-9501 Protein denotes RIG-I
T4471 9480-9484 Protein denotes IRF3
T4470 9456-9461 Protein denotes RIG-I
T783 7622-7631 Negative_regulation denotes deficient
T782 6852-6863 Protein_catabolism denotes degradation
T781 6424-6434 Positive_regulation denotes activation
T780 5969-5975 Entity denotes domain
T779 5872-5884 Localization denotes translocates
T778 5783-5789 Entity denotes domain
T777 5759-5768 Binding denotes associate
T776 5742-5749 Entity denotes domains
T775 5724-5731 Binding denotes binding
T774 5335-5344 Negative_regulation denotes deficient
T773 5265-5274 Negative_regulation denotes deficient
T772 4139-4148 Gene_expression denotes producing
T771 8527-8532 Protein denotes IRF-3
T770 8491-8495 Protein denotes TLR3
T769 8480-8485 Protein denotes RIG-I
T768 7531-7536 Protein denotes IL-1R
T767 7516-7520 Protein denotes TLR4
T766 7490-7504 Protein denotes TNF receptor I
T765 7062-7067 Protein denotes RBCK1
T764 7046-7052 Protein denotes TRIM21
T763 7035-7039 Protein denotes RAUL
T762 6993-6997 Protein denotes IRF7
T761 6984-6988 Protein denotes IRF3
T760 6822-6827 Protein denotes TRAF3
T759 6813-6817 Protein denotes MAVS
T758 6782-6789 Protein denotes TRIAD3A
T757 6768-6772 Protein denotes AIP4
T756 6602-6605 Protein denotes RLR
T755 6530-6534 Protein denotes CYLD
T754 6519-6523 Protein denotes DUBA
T753 6440-6445 Protein denotes RIG-I
T752 6419-6423 Protein denotes IRF3
T751 6377-6382 Protein denotes TRAF3
T750 6356-6361 Protein denotes TRAF6
T749 6280-6285 Protein denotes RIG-I
T748 6225-6231 Protein denotes Riplet
T747 6209-6215 Protein denotes TRIM25
T746 6122-6127 Protein denotes RIG-I
T745 6011-6015 Protein denotes MAVS
T744 5828-5834 Protein denotes Cardif
T743 5822-5826 Protein denotes VISA
T742 5815-5820 Protein denotes IPS-1
T741 5797-5801 Protein denotes MAVS
T740 5753-5758 Protein denotes RIG-I
T739 5581-5586 Protein denotes RIG-I
T738 5330-5334 Protein denotes TLR3
T737 5259-5264 Protein denotes RIG-I
T736 5213-5218 Protein denotes RIG-I
T735 5003-5008 Protein denotes RIG-I
T734 4994-4998 Protein denotes TLR3
T733 4054-4059 Protein denotes IFI16
T732 4031-4035 Protein denotes AIM2
T731 3982-3985 Protein denotes DAI
T730 3976-3980 Protein denotes TLR9
T729 3880-3884 Protein denotes MDA5
T728 3873-3878 Protein denotes RIG-I
T727 3867-3871 Protein denotes TLR3
T726 3837-3841 Protein denotes Nod2
T725 3831-3835 Protein denotes TLR8
T724 3825-3829 Protein denotes TLR7
T723 3461-3465 Protein denotes IRF7
T722 3452-3456 Protein denotes IRF3
T721 3329-3334 Protein denotes IFN-β
T720 3318-3323 Protein denotes IFN-α
T719 3304-3316 Protein denotes interferon-α
T718 3274-3278 Protein denotes IL-1
T717 3265-3269 Protein denotes IL-6
T716 3260-3263 Protein denotes TNF
T12 1512-1522 Negative_regulation denotes inhibition
T11 870-879 Negative_regulation denotes deficient
T10 744-752 Negative_regulation denotes knockout
T8 992-996 Protein denotes IRF3
T7 463-468 Protein denotes RIG-I
T6 433-462 Protein denotes pathogen recognition receptor
R526 T752 T781 themeOf IRF3,activation
R6091 T8612 T8636 themeOf MIP-2,production
R518 T720 T718 equivalentTo IFN-α,IL-1
R519 T720 T717 equivalentTo IFN-α,IL-6
R520 T720 T716 equivalentTo IFN-α,TNF
R521 T737 T773 themeOf RIG-I,deficient
R522 T738 T774 themeOf TLR3,deficient
R523 T742 T779 themeOf IPS-1,translocates
R524 T743 T779 themeOf VISA,translocates
R525 T744 T779 themeOf Cardif,translocates
R527 T753 T781 causeOf RIG-I,activation
R528 T757 T782 themeOf AIP4,degradation
R529 T758 T782 themeOf TRIAD3A,degradation
R530 T759 T782 themeOf MAVS,degradation
R3115 T4477 T4526 causeOf IRF3,dependent
R3116 T4478 T4527 themeOf luciferase,activation
R3117 T4479 T4528 causeOf truncated constitutive active form,induced
R3118 T4480 T4479 themeOf RIG-I,truncated constitutive active form
R3119 T4480 T4528 causeOf RIG-I,induced
R3120 T4483 T4530 themeOf IRF3,expressed
R3121 T4484 T4530 themeOf IRF7,expressed
R3122 T4484 T4531 themeOf IRF7,upregulated
R3123 T4485 T4531 themeOf IRF7,upregulated
R3124 T4488 T4534 themeOf IRF7,expression
R3125 T4489 T4533 themeOf IRF7,transfected
R3126 T4490 T4533 themeOf luciferase,transfected
R3127 T4491 T4536 themeOf IRF7,expression
R3128 T4494 T4539 causeOf RIG-I,induced
R3129 T4495 T4540 themeOf IRF7,activation
R3130 T4497 T4541 themeOf IRF3,activation
R3131 T4498 T4541 themeOf 7,activation
R3132 T4501 T4545 themeOf RIG-I,bind
R3133 T4503 T4546 themeOf TLR3,induce
R3134 T4505 T4552 themeOf IκBα,degradation
R3135 T4505 T4551 themeOf IκBα,phosphorylation
R3136 T4506 T4554 themeOf p65,translocation
R3137 T4507 T4559 themeOf IRF3,dimerization
R3138 T4508 T4559 themeOf TBK1,dimerization
R3139 T4510 T4562 themeOf IRF3,phosphorylation
R3140 T4511 T4564 themeOf p65,translocation
R3141 T4512 T4564 themeOf IRF3,translocation
R3142 T4513 T4567 themeOf IL-6,expression
R3143 T4514 T4567 themeOf TNF,expression
R3144 T4515 T4567 themeOf IRF3,expression
R3145 T4516 T4569 themeOf IFNβ,expression
R3146 T4518 T4570 themeOf IL-6,secreted
R3147 T4520 T4570 themeOf IFNβ,secreted
R3148 T4526 T4525 themeOf dependent,prevents
R3149 T4527 T4526 themeOf activation,dependent
R3150 T4527 T4528 themeOf activation,induced
R3151 T4530 T4531 themeOf expressed,upregulated
R3152 T4539 T4538 themeOf induced,prevented
R3153 T4540 T4539 themeOf activation,induced
R3154 T4540 T4538 themeOf activation,prevented
R3155 T4548 T4547 themeOf expression,induced
R3156 T4549 T4550 causeOf deficient,increased
R3157 T4551 T4550 themeOf phosphorylation,increased
R3158 T4552 T4550 themeOf degradation,increased
R3159 T4553 T4554 locationOf nuclear,translocation
R3160 T4554 T4555 themeOf translocation,enhanced
R3161 T4558 T4557 themeOf serine residues,phosphorylation
R3162 T4558 T4507 partOf serine residues,IRF3
R3163 T4563 T4564 locationOf nuclear,translocation
R3164 T4567 T4566 themeOf expression,controls
R3165 T4569 T4568 themeOf expression,control
R3166 T4570 T4571 themeOf secreted,increased
R5381 T7638 T7656 themeOf IL-6,expression
R5382 T7639 T7656 themeOf IFNβ,expression
R5383 T7642 T7658 themeOf IL-6,secretion
R5384 T7642 T7657 themeOf IL-6,Expression
R5385 T7643 T7658 themeOf TNF,secretion
R5386 T7644 T7658 themeOf IFNβ,secretion
R5387 T7645 T7658 themeOf IFNα4,secretion
R5388 T7646 T7658 themeOf MCP-1,secretion
R5389 T7647 T7646 equivalentTo ccl2,MCP-1
R5390 T7648 T7658 themeOf KC,secretion
R5391 T7649 T7646 equivalentTo cxcl1,MCP-1
R5392 T7649 T7648 equivalentTo cxcl1,KC
R5393 T7656 T7655 themeOf expression,enhanced
R6084 T8597 T8623 themeOf IL-6,higher
R6085 T8598 T8625 themeOf MCP-1,production
R6086 T8603 T8626 themeOf KC,higher
R6087 T8604 T8626 themeOf MIP-2,higher
R6088 T8606 T8627 themeOf MCP-1,expression
R6089 T8609 T8608 equivalentTo GrB,Granzyme B
R6090 T8611 T8636 themeOf KC,production
R6092 T8614 T8638 themeOf TNF,increased
R6093 T8615 T8638 themeOf IL-1β,increased
R6094 T8616 T8639 themeOf MCP-1,production
R6095 T8619 T8618 themeOf expression,role
R6096 T8625 T8624 themeOf production,increase
R6097 T8630 T8631 themeOf expression,altered
R6098 T8632 T8631 causeOf absence,altered
R6099 T8635 T8634 themeOf expression,affected
R6100 T8636 T8637 themeOf production,stronger
R6101 T8639 T8640 themeOf production,increased
R8465 T11573 T11599 themeOf MCP-1,production
R8466 T11581 T11605 themeOf MIP-2,activation
R8467 T11583 T11605 themeOf IRF3,activation
R8468 T11590 T11609 themeOf TBK1,ubiquitination
R8469 T11591 T11609 themeOf IKKε,ubiquitination
R12117 T16081 T16087 themeOf Granzyme B,expressing
R12118 T16082 T16081 equivalentTo GrB,Granzyme B
R12119 T16085 T16088 themeOf CD3,expression
R12120 T16086 T16088 themeOf CD8,expression
R14494 T19284 T19297 themeOf IκBα,phosphorylation
R14495 T19284 T19298 themeOf IκBα,degradation
R14496 T19285 T19299 themeOf IRF3,phosphorylation
R14497 T19287 T19302 themeOf IRF3,translocation
R14498 T19301 T19302 locationOf Nuclear,translocation
R15135 T20251 T20259 themeOf IL-6,mRNA expression
R15136 T20252 T20259 themeOf IFNβ,mRNA expression
R15137 T20255 T20260 themeOf IL-6,mRNA expression
R15138 T20256 T20260 themeOf IFNβ,mRNA expression
R15842 T21202 T21207 causeOf MIP-2,following
R15843 T21203 T21207 causeOf MCP-1,following
R15844 T21204 T21207 causeOf IL-6,following