PMC:3279418 / 7229-10327 JSON TXT

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2_test

Id	Subject	Object	Predicate	Lexical cue
22348129-20193011-89575674	147-149	20193011	denotes	13
22348129-20193011-89575675	337-339	20193011	denotes	13
22348129-15593126-89575676	383-385	15593126	denotes	14
22348129-17589544-89575677	2458-2460	17589544	denotes	15
22348129-17170756-89575678	2464-2466	17170756	denotes	16
22348129-16691244-89575679	2770-2772	16691244	denotes	17
22348129-19686699-89575680	2776-2778	19686699	denotes	18
T44705	147-149	20193011	denotes	13
T94367	337-339	20193011	denotes	13
T12018	383-385	15593126	denotes	14
T52721	2458-2460	17589544	denotes	15
T13133	2464-2466	17170756	denotes	16
T64617	2770-2772	16691244	denotes	17
T40972	2776-2778	19686699	denotes	18

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T3281	0-11	NN	denotes	Phenotyping
T3282	12-19	JJ	denotes	splenic
T3283	20-22	NN	denotes	DC
T3284	23-26	CC	denotes	and
T3285	27-31	NN	denotes	BMDC
T3286	32-36	IN	denotes	from
T3287	37-39	NN	denotes	WT
T3288	40-43	CC	denotes	and
T3289	44-48	NN	denotes	cpdm
T3290	49-53	NN	denotes	mice
T3291	54-56	NN	denotes	DC
T3292	57-60	VB	denotes	are
T3293	61-74	JJ	denotes	heterogeneous
T3294	75-78	CC	denotes	and
T3295	79-82	MD	denotes	can
T3296	83-85	VB	denotes	be
T3297	86-97	VB	denotes	categorized
T3298	98-102	IN	denotes	into
T3299	103-111	JJ	denotes	multiple
T3300	112-120	NN	denotes	subtypes
T3301	121-126	VB	denotes	based
T3302	127-129	IN	denotes	on
T3303	130-137	NN	denotes	surface
T3304	138-145	NN	denotes	markers
T3305	146-147	-LRB-	denotes	[
T3306	147-149	CD	denotes	13
T3307	149-150	-RRB-	denotes	]
T3308	152-154	TO	denotes	To
T3309	155-164	VB	denotes	determine
T3310	165-167	IN	denotes	if
T3311	168-171	DT	denotes	the
T3312	172-179	NNP	denotes	Sharpin
T3313	180-188	NN	denotes	mutation
T3314	189-196	VB	denotes	affects
T3315	197-199	NN	denotes	DC
T3316	200-211	NN	denotes	development
T3317	212-214	IN	denotes	in
T3318	215-223	JJ	denotes	lymphoid
T3319	224-231	NN	denotes	tissues
T3320	231-232	-COMMA-	denotes	,
T3321	233-238	NN	denotes	mouse
T3322	239-246	NN	denotes	spleens
T3323	247-251	VB	denotes	were
T3324	252-260	VB	denotes	examined
T3325	261-264	IN	denotes	for
T3326	265-268	DT	denotes	the
T3327	269-281	NN	denotes	distribution
T3328	282-284	IN	denotes	of
T3329	285-297	JJ	denotes	conventional
T3330	298-300	NN	denotes	DC
T3331	301-302	-LRB-	denotes	(
T3332	302-305	NN	denotes	cDC
T3333	305-306	-COLON-	denotes	;
T3334	307-318	JJ	denotes	CD11c+CD8α+
T3335	319-322	CC	denotes	and
T3336	323-334	NN	denotes	CD11c+CD8α−
T3337	334-335	-RRB-	denotes	)
T3338	336-337	-LRB-	denotes	[
T3339	337-339	CD	denotes	13
T3340	339-340	-RRB-	denotes	]
T3341	341-344	CC	denotes	and
T3342	345-357	JJ	denotes	plasmacytoid
T3343	358-360	NN	denotes	DC
T3344	361-362	-LRB-	denotes	(
T3345	362-365	NN	denotes	pDC
T3346	365-366	-COLON-	denotes	;
T3347	367-380	JJ	denotes	CD11c−PDCA-1+
T3348	380-381	-RRB-	denotes	)
T3349	382-383	-LRB-	denotes	[
T3350	383-385	CD	denotes	14
T3351	385-386	-RRB-	denotes	]
T3352	388-391	DT	denotes	The
T3353	392-403	NN	denotes	percentages
T3354	404-407	IN	denotes	for
T3355	408-415	JJ	denotes	splenic
T3356	416-419	NN	denotes	cDC
T3357	420-423	CC	denotes	and
T3358	424-427	NN	denotes	pDC
T3359	428-432	VB	denotes	were
T3360	433-437	DT	denotes	both
T3361	438-445	VB	denotes	reduced
T3362	446-448	IN	denotes	in
T3363	449-453	NN	denotes	cpdm
T3364	454-458	NN	denotes	mice
T3365	459-463	WRB	denotes	when
T3366	464-472	VB	denotes	compared
T3367	473-477	IN	denotes	with
T3368	478-480	JJ	denotes	WT
T3369	481-489	NN	denotes	controls
T3370	490-491	-LRB-	denotes	(
T3371	491-495	NNP	denotes	Fig.
T3372	496-498	NN	denotes	2A
T3373	498-499	-RRB-	denotes	)
T3374	501-508	RB	denotes	However
T3375	508-509	-COMMA-	denotes	,
T3376	510-514	WRB	denotes	when
T3377	515-520	VB	denotes	gated
T3378	521-523	IN	denotes	on
T3379	524-530	JJ	denotes	CD11c+
T3380	531-534	NN	denotes	cDC
T3381	534-535	-COMMA-	denotes	,
T3382	536-539	DT	denotes	the
T3383	540-551	NN	denotes	percentages
T3384	552-554	IN	denotes	of
T3385	555-560	JJ	denotes	CD8α+
T3386	561-564	CC	denotes	and
T3387	565-570	NN	denotes	CD8α−
T3388	571-576	NN	denotes	cells
T3389	577-581	VB	denotes	were
T3390	582-585	RB	denotes	not
T3391	586-594	VB	denotes	affected
T3392	595-597	IN	denotes	by
T3393	598-605	NN	denotes	SHARPIN
T3394	606-616	NN	denotes	deficiency
T3395	617-618	-LRB-	denotes	(
T3396	618-622	NN	denotes	Fig.
T3397	623-625	NN	denotes	2A
T3398	625-626	-RRB-	denotes	)
T3399	628-633	IN	denotes	Since
T3400	634-637	DT	denotes	the
T3401	638-644	NN	denotes	spleen
T3402	645-647	IN	denotes	of
T3403	648-652	NN	denotes	cpdm
T3404	653-657	NN	denotes	mice
T3405	658-660	VB	denotes	is
T3406	661-669	RB	denotes	markedly
T3407	670-678	VB	denotes	enlarged
T3408	679-682	CC	denotes	and
T3409	683-691	VB	denotes	contains
T3410	692-697	CD	denotes	three
T3411	698-703	NN	denotes	times
T3412	704-706	IN	denotes	as
T3413	707-711	JJ	denotes	many
T3414	712-717	NN	denotes	cells
T3415	718-719	-LRB-	denotes	(
T3416	719-723	NN	denotes	Fig.
T3417	724-726	NN	denotes	1C
T3418	726-727	-RRB-	denotes	)
T3419	727-728	-COMMA-	denotes	,
T3420	729-732	DT	denotes	the
T3421	733-742	JJ	denotes	different
T3422	743-754	NN	denotes	percentages
T3423	755-757	IN	denotes	of
T3424	758-765	JJ	denotes	splenic
T3425	766-769	NN	denotes	cDC
T3426	770-773	CC	denotes	and
T3427	774-777	NN	denotes	pDC
T3428	778-785	IN	denotes	between
T3429	786-788	NN	denotes	WT
T3430	789-792	CC	denotes	and
T3431	793-799	JJ	denotes	mutant
T3432	800-804	NN	denotes	mice
T3433	805-812	VB	denotes	reflect
T3434	813-816	DT	denotes	the
T3435	817-826	VB	denotes	increased
T3436	827-833	NN	denotes	number
T3437	834-836	IN	denotes	of
T3438	837-842	JJ	denotes	total
T3439	843-849	NN	denotes	spleen
T3440	850-855	NN	denotes	cells
T3441	856-862	RB	denotes	rather
T3442	863-867	IN	denotes	than
T3443	868-869	DT	denotes	a
T3444	870-879	NN	denotes	reduction
T3445	880-882	IN	denotes	in
T3446	883-886	NN	denotes	cDC
T3447	887-890	CC	denotes	and
T3448	891-894	NN	denotes	pDC
T3449	895-902	NN	denotes	numbers
T3450	904-909	DT	denotes	These
T3451	910-914	NN	denotes	data
T3452	915-923	VB	denotes	indicate
T3453	924-928	IN	denotes	that
T3454	929-932	DT	denotes	the
T3455	933-940	NNP	denotes	Sharpin
T3456	941-949	NN	denotes	mutation
T3457	950-954	VB	denotes	does
T3458	955-958	RB	denotes	not
T3459	959-965	VB	denotes	affect
T3460	966-969	DT	denotes	the
T3461	970-982	NN	denotes	distribution
T3462	983-985	IN	denotes	of
T3463	986-989	DT	denotes	the
T3464	990-998	VB	denotes	examined
T3465	999-1001	NN	denotes	DC
T3466	1002-1009	NN	denotes	subsets
T3467	1010-1012	IN	denotes	in
T3468	1013-1016	DT	denotes	the
T3469	1017-1023	NN	denotes	spleen
T3470	2347-2351	NN	denotes	BMDC
T3471	2352-2356	IN	denotes	from
T3472	2357-2359	FW	denotes	in
T3473	2360-2365	FW	denotes	vitro
T3474	2366-2374	NN	denotes	cultures
T3475	2375-2387	RB	denotes	functionally
T3476	2388-2396	VB	denotes	resemble
T3477	2397-2409	JJ	denotes	non-lymphoid
T3478	2410-2416	NN	denotes	tissue
T3479	2417-2419	NN	denotes	DC
T3480	2420-2423	CC	denotes	and
T3481	2424-2440	JJ	denotes	monocyte-derived
T3482	2441-2453	JJ	denotes	inflammatory
T3483	2454-2456	NN	denotes	DC
T3484	2457-2458	-LRB-	denotes	[
T3485	2458-2460	CD	denotes	15
T3486	2460-2461	-RRB-	denotes	]
T3487	2461-2462	-COMMA-	denotes	,
T3488	2463-2464	-LRB-	denotes	[
T3489	2464-2466	CD	denotes	16
T3490	2466-2467	-RRB-	denotes	]
T3491	2469-2472	DT	denotes	The
T3492	2473-2479	NN	denotes	yields
T3493	2480-2482	IN	denotes	of
T3494	2483-2487	NN	denotes	BMDC
T3495	2488-2492	IN	denotes	from
T3496	2493-2495	NN	denotes	WT
T3497	2496-2499	CC	denotes	and
T3498	2500-2504	NN	denotes	cpdm
T3499	2505-2509	NN	denotes	mice
T3500	2510-2514	VB	denotes	were
T3501	2515-2522	JJ	denotes	similar
T3502	2524-2528	NN	denotes	BMDC
T3503	2529-2533	VB	denotes	were
T3504	2534-2540	JJ	denotes	CD11c+
T3505	2541-2544	CC	denotes	and
T3506	2545-2548	NN	denotes	MHC
T3507	2549-2552	JJ	denotes	II+
T3508	2553-2557	IN	denotes	with
T3509	2558-2561	JJ	denotes	low
T3510	2562-2572	NN	denotes	expression
T3511	2573-2575	IN	denotes	of
T3512	2576-2590	JJ	denotes	co-stimulatory
T3513	2591-2600	NN	denotes	molecules
T3514	2601-2605	NN	denotes	CD40
T3515	2605-2606	-COMMA-	denotes	,
T3516	2607-2611	NN	denotes	CD80
T3517	2611-2612	-COMMA-	denotes	,
T3518	2613-2616	CC	denotes	and
T3519	2617-2621	NN	denotes	CD86
T3520	2623-2626	DT	denotes	The
T3521	2627-2631	NN	denotes	TLR3
T3522	2632-2638	NN	denotes	ligand
T3523	2639-2643	NN	denotes	poly
T3524	2644-2645	NN	denotes	I
T3525	2645-2646	-COLON-	denotes	:
T3526	2646-2647	NN	denotes	C
T3527	2648-2651	CC	denotes	and
T3528	2652-2655	DT	denotes	the
T3529	2656-2660	NN	denotes	TLR4
T3530	2661-2667	NN	denotes	ligand
T3531	2668-2671	NN	denotes	LPS
T3532	2672-2676	DT	denotes	each
T3533	2677-2685	VB	denotes	activate
T3534	2686-2697	VB	denotes	overlapping
T3535	2698-2701	CC	denotes	but
T3536	2702-2711	JJ	denotes	different
T3537	2712-2721	NN	denotes	signaling
T3538	2722-2730	NN	denotes	pathways
T3539	2731-2734	CC	denotes	and
T3540	2735-2739	VB	denotes	were
T3541	2740-2744	VB	denotes	used
T3542	2745-2747	TO	denotes	to
T3543	2748-2754	VB	denotes	induce
T3544	2755-2757	NN	denotes	DC
T3545	2758-2768	NN	denotes	maturation
T3546	2769-2770	-LRB-	denotes	[
T3547	2770-2772	CD	denotes	17
T3548	2772-2773	-RRB-	denotes	]
T3549	2773-2774	-COMMA-	denotes	,
T3550	2775-2776	-LRB-	denotes	[
T3551	2776-2778	CD	denotes	18
T3552	2778-2779	-RRB-	denotes	]
T3553	2781-2791	NN	denotes	Incubation
T3554	2792-2796	IN	denotes	with
T3555	2797-2800	DT	denotes	the
T3556	2801-2804	NN	denotes	TLR
T3557	2805-2813	NN	denotes	agonists
T3558	2814-2817	IN	denotes	for
T3559	2818-2820	CD	denotes	24
T3560	2821-2826	NN	denotes	hours
T3561	2827-2835	VB	denotes	resulted
T3562	2836-2838	IN	denotes	in
T3563	2839-2848	VB	denotes	increased
T3564	2849-2859	NN	denotes	expression
T3565	2860-2862	IN	denotes	of
T3566	2863-2867	NN	denotes	CD40
T3567	2867-2868	-COMMA-	denotes	,
T3568	2869-2873	NN	denotes	CD80
T3569	2873-2874	-COMMA-	denotes	,
T3570	2875-2878	CC	denotes	and
T3571	2879-2883	NN	denotes	CD86
T3572	2884-2886	IN	denotes	on
T3573	2887-2891	NN	denotes	BMDC
T3574	2891-2892	-COLON-	denotes	;
T3575	2893-2900	RB	denotes	however
T3576	2900-2901	-COMMA-	denotes	,
T3577	2902-2907	EX	denotes	there
T3578	2908-2911	VB	denotes	was
T3579	2912-2914	DT	denotes	no
T3580	2915-2925	NN	denotes	difference
T3581	2926-2928	IN	denotes	in
T3582	2929-2932	DT	denotes	the
T3583	2933-2943	NN	denotes	expression
T3584	2944-2950	NN	denotes	levels
T3585	2951-2953	IN	denotes	of
T3586	2954-2959	DT	denotes	these
T3587	2960-2967	NN	denotes	markers
T3588	2968-2975	IN	denotes	between
T3589	2976-2978	NN	denotes	WT
T3590	2979-2982	CC	denotes	and
T3591	2983-2987	NN	denotes	cpdm
T3592	2988-2992	NN	denotes	BMDC
T3593	2993-2994	-LRB-	denotes	(
T3594	2994-2998	NN	denotes	Fig.
T3595	2999-3001	NN	denotes	2B
T3596	3001-3002	-RRB-	denotes	)
T3597	3004-3008	RB	denotes	Thus
T3598	3008-3009	-COMMA-	denotes	,
T3599	3010-3017	NN	denotes	SHARPIN
T3600	3018-3028	NN	denotes	deficiency
T3601	3029-3032	VB	denotes	did
T3602	3033-3036	RB	denotes	not
T3603	3037-3046	VB	denotes	influence
T3604	3047-3050	DT	denotes	the
T3605	3051-3061	NN	denotes	expression
T3606	3062-3064	IN	denotes	of
T3607	3065-3079	JJ	denotes	co-stimulatory
T3608	3080-3089	NN	denotes	molecules
T3609	3090-3092	IN	denotes	by
T3610	3093-3097	NN	denotes	BMDC
T13537	1069-1075	NN	denotes	Effect
T13538	1076-1078	IN	denotes	of
T13539	1079-1086	NNP	denotes	Sharpin
T13540	1087-1095	NN	denotes	mutation
T13541	1096-1098	IN	denotes	on
T13542	1099-1101	NN	denotes	DC
T13543	1102-1116	NN	denotes	subpopulations
T13544	1117-1120	CC	denotes	and
T13545	1121-1131	NN	denotes	maturation
T13546	1133-1134	-LRB-	denotes	(
T13547	1134-1135	NN	denotes	A
T13548	1135-1136	-RRB-	denotes	)
T13549	1137-1144	NN	denotes	Spleens
T13550	1145-1149	IN	denotes	from
T13551	1150-1152	NN	denotes	WT
T13552	1153-1156	CC	denotes	and
T13553	1157-1161	NN	denotes	cpdm
T13554	1162-1166	NN	denotes	mice
T13555	1167-1171	VB	denotes	were
T13556	1172-1180	VB	denotes	isolated
T13557	1181-1184	CC	denotes	and
T13558	1185-1192	JJ	denotes	subject
T13559	1193-1195	TO	denotes	to
T13560	1196-1207	NN	denotes	collagenase
T13561	1208-1211	CC	denotes	and
T13562	1212-1217	NN	denotes	DNase
T13563	1218-1227	NN	denotes	digestion
T13564	1229-1232	DT	denotes	The
T13565	1233-1241	VB	denotes	obtained
T13566	1242-1249	JJ	denotes	splenic
T13567	1250-1261	NN	denotes	homogenates
T13568	1262-1266	VB	denotes	were
T13569	1267-1278	VB	denotes	centrifuged
T13570	1279-1283	IN	denotes	over
T13571	1284-1285	DT	denotes	a
T13572	1286-1293	NN	denotes	Percoll
T13573	1294-1302	NN	denotes	gradient
T13574	1303-1304	-LRB-	denotes	(
T13575	1304-1306	CD	denotes	35
T13576	1306-1307	NN	denotes	%
T13577	1308-1311	CC	denotes	and
T13578	1312-1314	CD	denotes	55
T13579	1314-1315	NN	denotes	%
T13580	1316-1323	NN	denotes	density
T13581	1323-1324	-RRB-	denotes	)
T13582	1325-1328	IN	denotes	for
T13583	1329-1331	CD	denotes	15
T13584	1332-1339	NN	denotes	minutes
T13585	1341-1344	DT	denotes	The
T13586	1345-1350	NN	denotes	bands
T13587	1351-1353	IN	denotes	at
T13588	1354-1357	DT	denotes	the
T13589	1358-1360	CD	denotes	35
T13590	1360-1361	NN	denotes	%
T13591	1361-1368	NN	denotes	-medium
T13592	1369-1372	CC	denotes	and
T13593	1373-1376	DT	denotes	the
T13594	1377-1382	CD	denotes	35–55
T13595	1382-1383	NN	denotes	%
T13596	1384-1393	NN	denotes	interface
T13597	1394-1398	VB	denotes	were
T13598	1399-1405	VB	denotes	pooled
T13599	1405-1406	-COMMA-	denotes	,
T13600	1407-1413	VB	denotes	washed
T13601	1414-1417	CC	denotes	and
T13602	1418-1425	VB	denotes	stained
T13603	1426-1430	IN	denotes	with
T13604	1431-1432	DT	denotes	a
T13605	1433-1444	NN	denotes	combination
T13606	1445-1447	IN	denotes	of
T13607	1448-1455	JJ	denotes	various
T13608	1456-1466	NN	denotes	antibodies
T13609	1467-1469	TO	denotes	to
T13610	1470-1475	VB	denotes	stain
T13611	1476-1485	JJ	denotes	different
T13612	1486-1488	NN	denotes	DC
T13613	1489-1496	NN	denotes	subsets
T13614	1496-1497	-COMMA-	denotes	,
T13615	1498-1510	JJ	denotes	conventional
T13616	1511-1522	NN	denotes	CD11c+CD8α+
T13617	1522-1523	-COMMA-	denotes	,
T13618	1524-1535	NN	denotes	CD11c+CD8α−
T13619	1536-1539	CC	denotes	and
T13620	1540-1552	JJ	denotes	plasmacytoid
T13621	1553-1555	NN	denotes	DC
T13622	1556-1557	-LRB-	denotes	(
T13623	1557-1570	JJ	denotes	CD11c−PDCA-1+
T13624	1570-1571	-RRB-	denotes	)
T13625	1571-1575	NN	denotes	.The
T13626	1576-1579	JJ	denotes	top
T13627	1580-1586	NN	denotes	panels
T13628	1587-1591	VB	denotes	were
T13629	1592-1597	VB	denotes	gated
T13630	1598-1600	IN	denotes	on
T13631	1601-1611	NN	denotes	FSChiSSClo
T13632	1612-1617	NN	denotes	cells
T13633	1618-1620	TO	denotes	to
T13634	1621-1625	VB	denotes	show
T13635	1626-1634	JJ	denotes	separate
T13636	1635-1646	NN	denotes	populations
T13637	1647-1649	IN	denotes	of
T13638	1650-1663	JJ	denotes	CD11c+PDCA-1−
T13639	1664-1667	CC	denotes	and
T13640	1668-1681	JJ	denotes	CD11c−PDCA-1+
T13641	1682-1687	NN	denotes	cells
T13642	1689-1696	RB	denotes	Further
T13643	1697-1703	VB	denotes	gating
T13644	1704-1706	IN	denotes	on
T13645	1707-1710	DT	denotes	the
T13646	1711-1724	JJ	denotes	CD11c+PDCA-1−
T13647	1725-1738	NN	denotes	subpopulation
T13648	1739-1743	VB	denotes	gave
T13649	1744-1747	DT	denotes	the
T13650	1748-1754	NN	denotes	bottom
T13651	1755-1760	NN	denotes	panel
T13652	1761-1765	WDT	denotes	that
T13653	1766-1772	VB	denotes	showed
T13654	1773-1776	CD	denotes	two
T13655	1777-1785	JJ	denotes	distinct
T13656	1786-1791	NN	denotes	pools
T13657	1792-1794	IN	denotes	of
T13658	1795-1806	JJ	denotes	CD11c+CD8α+
T13659	1807-1810	CC	denotes	and
T13660	1811-1822	NN	denotes	CD11c+CD8α−
T13661	1823-1828	NN	denotes	cells
T13662	1830-1841	NN	denotes	Percentages
T13663	1842-1846	VB	denotes	were
T13664	1847-1857	VB	denotes	calculated
T13665	1858-1863	VB	denotes	based
T13666	1864-1866	IN	denotes	on
T13667	1867-1870	DT	denotes	the
T13668	1871-1879	JJ	denotes	parental
T13669	1880-1890	NN	denotes	population
T13670	1891-1894	CC	denotes	and
T13671	1895-1899	VB	denotes	were
T13672	1900-1912	RB	denotes	additionally
T13673	1913-1918	VB	denotes	shown
T13674	1919-1921	IN	denotes	as
T13675	1922-1925	NN	denotes	bar
T13676	1926-1932	NN	denotes	graphs
T13677	1933-1934	-LRB-	denotes	(
T13678	1934-1939	NN	denotes	n = 2
T13679	1939-1940	-RRB-	denotes	)
T13680	1941-1942	-LRB-	denotes	(
T13681	1942-1943	NN	denotes	B
T13682	1943-1944	-RRB-	denotes	)
T13683	1944-1945	-LRB-	denotes	.
T13684	1946-1947	NN	denotes	(
T13685	1947-1948	-RRB-	denotes	C
T13686	1948-1950	NN	denotes	)
T13687	1950-1953	CC	denotes	WT
T13688	1953-1957	NN	denotes	and
T13689	1957-1961	NN	denotes	cpdm
T13690	1962-1963	-LRB-	denotes	B
T13691	1963-1968	CD	denotes	MDC (
T13692	1968-1969	-RRB-	denotes	5
T13693	1969-1974	NN	denotes	×105)
T13694	1975-1979	VB	denotes	cell
T13695	1979-1989	VB	denotes	s were sti
T13696	1989-1993	IN	denotes	mula
T13697	1993-1999	NN	denotes	ted wi
T13698	1999-2000	-COMMA-	denotes	t
T13699	2000-2003	CD	denotes	h m
T13700	2003-2008	NN	denotes	edium
T13701	2008-2011	NN	denotes	, 1
T13702	2011-2013	CC	denotes	00
T13703	2014-2016	CD	denotes	ng
T13704	2016-2021	NN	denotes	/ml L
T13705	2021-2025	NN	denotes	PS o
T13706	2025-2026	NN	denotes	r
T13707	2027-2028	-COLON-	denotes	2
T13708	2028-2029	NN	denotes	5
T13709	2030-2033	IN	denotes	µg/
T13710	2033-2035	CD	denotes	ml
T13711	2036-2041	NN	denotes	poly
T13712	2059-2062	DT	denotes	The
T13713	2063-2068	NN	denotes	cells
T13714	2069-2073	VB	denotes	were
T13715	2074-2081	VB	denotes	labeled
T13716	2082-2086	IN	denotes	with
T13717	2087-2097	JJ	denotes	PE-labeled
T13718	2098-2107	NN	denotes	anti-CD40
T13719	2107-2108	-COMMA-	denotes	,
T13720	2109-2118	NN	denotes	anti-CD80
T13721	2118-2119	-COMMA-	denotes	,
T13722	2120-2123	CC	denotes	and
T13723	2124-2133	NN	denotes	anti-CD86
T13724	2133-2134	-COMMA-	denotes	,
T13725	2135-2138	CC	denotes	and
T13726	2139-2148	VB	denotes	subjected
T13727	2149-2151	TO	denotes	to
T13728	2152-2156	VB	denotes	flow
T13729	2157-2166	NN	denotes	cytometry
T13730	2167-2175	NN	denotes	analysis
T13731	2177-2180	DT	denotes	The
T13732	2181-2192	NN	denotes	populations
T13733	2193-2198	VB	denotes	shown
T13734	2199-2201	IN	denotes	in
T13735	2202-2212	NN	denotes	histograms
T13736	2213-2217	VB	denotes	were
T13737	2218-2223	VB	denotes	gated
T13738	2224-2226	IN	denotes	on
T13739	2227-2233	JJ	denotes	CD11c+
T13740	2234-2239	NN	denotes	cells
T13741	2241-2250	JJ	denotes	Unstained
T13742	2251-2256	NN	denotes	cells
T13743	2257-2263	VB	denotes	served
T13744	2264-2266	IN	denotes	as
T13745	2267-2275	JJ	denotes	negative
T13746	2276-2284	NN	denotes	controls
T13747	2286-2293	NN	denotes	Results
T13748	2294-2297	VB	denotes	are
T13749	2298-2312	JJ	denotes	representative
T13750	2313-2315	IN	denotes	of
T13751	2316-2319	CD	denotes	two
T13752	2320-2331	JJ	denotes	independent
T13753	2332-2343	NN	denotes	experiments
R2707	T3283	T3281	arg1Of	DC,Phenotyping
R2708	T3283	T3282	arg1Of	DC,splenic
R2709	T3283	T3284	arg1Of	DC,and
R2710	T3285	T3284	arg2Of	BMDC,and
R2711	T3285	T3286	arg1Of	BMDC,from
R2712	T3287	T3288	arg1Of	WT,and
R2715	T3290	T3286	arg2Of	mice,from
R2716	T3290	T3287	arg1Of	mice,WT
R2717	T3291	T3292	arg1Of	DC,are
R2718	T3291	T3293	arg1Of	DC,heterogeneous
R2719	T3291	T3295	arg1Of	DC,can
R2720	T3291	T3296	arg1Of	DC,be
R2721	T3291	T3297	arg2Of	DC,categorized
R2722	T3292	T3294	arg1Of	are,and
R2723	T3293	T3292	arg2Of	heterogeneous,are
R2724	T3297	T3294	arg2Of	categorized,and
R2725	T3297	T3295	arg2Of	categorized,can
R2726	T3297	T3296	arg2Of	categorized,be
R2727	T3297	T3298	arg1Of	categorized,into
R2728	T3300	T3298	arg2Of	subtypes,into
R2729	T3300	T3299	arg1Of	subtypes,multiple
R2730	T3300	T3301	arg1Of	subtypes,based
R2731	T3302	T3301	arg2Of	on,based
R2732	T3304	T3302	arg2Of	markers,on
R2733	T3304	T3303	arg1Of	markers,surface
R2734	T3304	T3305	arg1Of	markers,[
R2735	T3306	T3305	arg2Of	13,[
R2736	T3307	T3305	arg3Of	],[
R2737	T3309	T3308	arg1Of	determine,To
R2738	T3313	T3311	arg1Of	mutation,the
R2739	T3313	T3312	arg1Of	mutation,Sharpin
R2740	T3313	T3314	arg1Of	mutation,affects
R2741	T3314	T3309	arg2Of	affects,determine
R2742	T3314	T3310	arg1Of	affects,if
R2743	T3314	T3317	arg1Of	affects,in
R2744	T3316	T3314	arg2Of	development,affects
R2745	T3316	T3315	arg1Of	development,DC
R2746	T3319	T3317	arg2Of	tissues,in
R2747	T3319	T3318	arg1Of	tissues,lymphoid
R2748	T3322	T3321	arg1Of	spleens,mouse
R2749	T3322	T3323	arg1Of	spleens,were
R2750	T3322	T3324	arg2Of	spleens,examined
R2751	T3324	T3308	modOf	examined,To
R2752	T3324	T3320	arg1Of	examined,","
R2753	T3324	T3323	arg2Of	examined,were
R2754	T3324	T3325	arg1Of	examined,for
R2755	T3324	T3349	arg1Of	examined,[
R2756	T3327	T3328	arg1Of	distribution,of
R2757	T3327	T3331	arg1Of	distribution,(
R2758	T3327	T3338	arg1Of	distribution,[
R2759	T3327	T3341	arg1Of	distribution,and
R2760	T3330	T3328	arg2Of	DC,of
R2761	T3330	T3329	arg1Of	DC,conventional
R2762	T3332	T3331	arg2Of	cDC,(
R2763	T3332	T3333	arg1Of	cDC,;
R2764	T3334	T3335	arg1Of	CD11c+CD8α+,and
R2765	T3335	T3333	arg2Of	and,;
R2766	T3336	T3335	arg2Of	CD11c+CD8α−,and
R2767	T3337	T3331	arg3Of	),(
R2768	T3339	T3338	arg2Of	13,[
R2769	T3340	T3338	arg3Of	],[
R2770	T3341	T3325	arg2Of	and,for
R2771	T3341	T3326	arg1Of	and,the
R2772	T3343	T3341	arg2Of	DC,and
R2773	T3343	T3342	arg1Of	DC,plasmacytoid
R2774	T3343	T3344	arg1Of	DC,(
R2775	T3345	T3344	arg2Of	pDC,(
R2776	T3345	T3346	arg1Of	pDC,;
R2777	T3345	T3347	arg1Of	pDC,CD11c−PDCA-1+
R2778	T3348	T3344	arg3Of	),(
R2779	T3350	T3349	arg2Of	14,[
R2780	T3351	T3349	arg3Of	],[
R2781	T3353	T3352	arg1Of	percentages,The
R2782	T3353	T3354	arg1Of	percentages,for
R2783	T3353	T3359	arg1Of	percentages,were
R2784	T3353	T3361	arg2Of	percentages,reduced
R2785	T3353	T3366	arg1Of	percentages,compared
R2786	T3356	T3357	arg1Of	cDC,and
R2787	T3357	T3354	arg2Of	and,for
R2788	T3357	T3355	arg1Of	and,splenic
R2789	T3358	T3357	arg2Of	pDC,and
R2790	T3361	T3359	arg2Of	reduced,were
R2791	T3361	T3360	arg1Of	reduced,both
R2792	T3361	T3362	arg1Of	reduced,in
R2793	T3361	T3365	arg1Of	reduced,when
R2794	T3364	T3362	arg2Of	mice,in
R2795	T3364	T3363	arg1Of	mice,cpdm
R2796	T3366	T3365	arg2Of	compared,when
R2797	T3366	T3367	arg1Of	compared,with
R2798	T3369	T3367	arg2Of	controls,with
R2799	T3369	T3368	arg1Of	controls,WT
R2800	T3369	T3370	arg1Of	controls,(
R2801	T3372	T3370	arg2Of	2A,(
R2802	T3372	T3371	arg1Of	2A,Fig.
R2803	T3373	T3370	arg3Of	),(
R2804	T3377	T3376	arg2Of	gated,when
R2805	T3377	T3378	arg1Of	gated,on
R2806	T3380	T3378	arg2Of	cDC,on
R2807	T3380	T3379	arg1Of	cDC,CD11c+
R2808	T3383	T3377	arg1Of	percentages,gated
R2809	T3383	T3382	arg1Of	percentages,the
R2810	T3383	T3384	arg1Of	percentages,of
R2811	T3383	T3389	arg1Of	percentages,were
R2812	T3383	T3391	arg2Of	percentages,affected
R2813	T3388	T3384	arg2Of	cells,of
R2814	T3388	T3385	arg1Of	cells,CD8α+
R2815	T3388	T3386	arg1Of	cells,and
R2816	T3388	T3387	arg1Of	cells,CD8α−
R2817	T3391	T3374	arg1Of	affected,However
R2818	T3391	T3375	arg1Of	affected,","
R2819	T3391	T3376	arg1Of	affected,when
R2820	T3391	T3381	arg1Of	affected,","
R2821	T3391	T3389	arg2Of	affected,were
R2822	T3391	T3390	arg1Of	affected,not
R2823	T3394	T3391	arg1Of	deficiency,affected
R2824	T3394	T3392	arg2Of	deficiency,by
R2825	T3394	T3393	arg1Of	deficiency,SHARPIN
R2826	T3394	T3395	arg1Of	deficiency,(
R2827	T3397	T3395	arg2Of	2A,(
R2828	T3397	T3396	arg1Of	2A,Fig.
R2829	T3398	T3395	arg3Of	),(
R2830	T3401	T3400	arg1Of	spleen,the
R2831	T3401	T3402	arg1Of	spleen,of
R2832	T3401	T3405	arg1Of	spleen,is
R2833	T3401	T3407	arg2Of	spleen,enlarged
R2834	T3401	T3409	arg1Of	spleen,contains
R2835	T3404	T3402	arg2Of	mice,of
R2836	T3404	T3403	arg1Of	mice,cpdm
R2837	T3407	T3405	arg2Of	enlarged,is
R2838	T3407	T3406	arg1Of	enlarged,markedly
R2839	T3407	T3408	arg1Of	enlarged,and
R2840	T3408	T3399	arg2Of	and,Since
R2841	T3409	T3408	arg2Of	contains,and
R2842	T3409	T3412	arg1Of	contains,as
R2843	T3411	T3409	arg2Of	times,contains
R2844	T3411	T3410	arg1Of	times,three
R2845	T3414	T3412	arg2Of	cells,as
R2846	T3414	T3413	arg1Of	cells,many
R2847	T3414	T3415	arg1Of	cells,(
R2848	T3417	T3415	arg2Of	1C,(
R2849	T3417	T3416	arg1Of	1C,Fig.
R2850	T3418	T3415	arg3Of	),(
R2851	T3422	T3420	arg1Of	percentages,the
R2852	T3422	T3421	arg1Of	percentages,different
R2853	T3422	T3423	arg1Of	percentages,of
R2854	T3422	T3433	arg1Of	percentages,reflect
R2855	T3425	T3426	arg1Of	cDC,and
R2856	T3426	T3423	arg2Of	and,of
R2857	T3426	T3424	arg1Of	and,splenic
R2858	T3426	T3428	arg1Of	and,between
R2859	T3427	T3426	arg2Of	pDC,and
R2860	T3429	T3430	arg1Of	WT,and
R2861	T3431	T3430	arg2Of	mutant,and
R2862	T3432	T3428	arg2Of	mice,between
R2863	T3432	T3429	arg1Of	mice,WT
R2864	T3432	T3431	arg1Of	mice,mutant
R2865	T3433	T3399	arg1Of	reflect,Since
R2866	T3433	T3419	arg1Of	reflect,","
R2867	T3436	T3434	arg1Of	number,the
R2868	T3436	T3435	arg2Of	number,increased
R2869	T3436	T3437	arg1Of	number,of
R2870	T3436	T3442	arg1Of	number,than
R2871	T3440	T3437	arg2Of	cells,of
R2872	T3440	T3438	arg1Of	cells,total
R2873	T3440	T3439	arg1Of	cells,spleen
R2874	T3442	T3433	arg2Of	than,reflect
R2875	T3442	T3441	arg1Of	than,rather
R2876	T3444	T3442	arg2Of	reduction,than
R2877	T3444	T3443	arg1Of	reduction,a
R2878	T3444	T3445	arg1Of	reduction,in
R2879	T3446	T3447	arg1Of	cDC,and
R2880	T3448	T3447	arg2Of	pDC,and
R2881	T3449	T3445	arg2Of	numbers,in
R2882	T3449	T3446	arg1Of	numbers,cDC
R2883	T3449	T3448	arg1Of	numbers,pDC
R2884	T3451	T3450	arg1Of	data,These
R2885	T3451	T3452	arg1Of	data,indicate
R2886	T3456	T3454	arg1Of	mutation,the
R2887	T3456	T3455	arg1Of	mutation,Sharpin
R2888	T3456	T3457	arg1Of	mutation,does
R2889	T3456	T3459	arg1Of	mutation,affect
R2890	T3459	T3452	arg2Of	affect,indicate
R2891	T3459	T3453	arg1Of	affect,that
R2892	T3459	T3457	arg2Of	affect,does
R2893	T3459	T3458	arg1Of	affect,not
R2894	T3461	T3459	arg2Of	distribution,affect
R2895	T3461	T3460	arg1Of	distribution,the
R2896	T3461	T3462	arg1Of	distribution,of
R2897	T3466	T3462	arg2Of	subsets,of
R2898	T3466	T3463	arg1Of	subsets,the
R2899	T3466	T3464	arg2Of	subsets,examined
R2900	T3466	T3465	arg1Of	subsets,DC
R2901	T3466	T3467	arg1Of	subsets,in
R2902	T3469	T3467	arg2Of	spleen,in
R2903	T3469	T3468	arg1Of	spleen,the
R2904	T3470	T3471	arg1Of	BMDC,from
R2905	T3470	T3476	arg1Of	BMDC,resemble
R2906	T3473	T3472	arg1Of	vitro,in
R2907	T3474	T3471	arg2Of	cultures,from
R2908	T3474	T3473	arg1Of	cultures,vitro
R2909	T3476	T3475	arg1Of	resemble,functionally
R2910	T3476	T3487	arg1Of	resemble,","
R2911	T3476	T3488	arg1Of	resemble,[
R2912	T3479	T3477	arg1Of	DC,non-lymphoid
R2913	T3479	T3478	arg1Of	DC,tissue
R2914	T3479	T3480	arg1Of	DC,and
R2915	T3480	T3476	arg2Of	and,resemble
R2916	T3483	T3480	arg2Of	DC,and
R2917	T3483	T3481	arg1Of	DC,monocyte-derived
R2918	T3483	T3482	arg1Of	DC,inflammatory
R2919	T3483	T3484	arg1Of	DC,[
R2920	T3485	T3484	arg2Of	15,[
R2921	T3486	T3484	arg3Of	],[
R2922	T3489	T3488	arg2Of	16,[
R2923	T3490	T3488	arg3Of	],[
R2924	T3492	T3491	arg1Of	yields,The
R2925	T3492	T3493	arg1Of	yields,of
R2926	T3492	T3500	arg1Of	yields,were
R2927	T3492	T3501	arg1Of	yields,similar
R2928	T3494	T3493	arg2Of	BMDC,of
R2929	T3494	T3495	arg1Of	BMDC,from
R2930	T3496	T3497	arg1Of	WT,and
R2931	T3498	T3497	arg2Of	cpdm,and
R2932	T3499	T3495	arg2Of	mice,from
R2933	T3499	T3496	arg1Of	mice,WT
R2934	T3499	T3498	arg1Of	mice,cpdm
R2935	T3501	T3500	arg2Of	similar,were
R2936	T3502	T3503	arg1Of	BMDC,were
R2937	T3502	T3504	arg1Of	BMDC,CD11c+
R2938	T3502	T3507	arg1Of	BMDC,II+
R2939	T3504	T3505	arg1Of	CD11c+,and
R2940	T3505	T3503	arg2Of	and,were
R2941	T3505	T3508	arg1Of	and,with
R2942	T3507	T3505	arg2Of	II+,and
R2943	T3507	T3506	arg1Of	II+,MHC
R2944	T3510	T3508	arg2Of	expression,with
R2945	T3510	T3509	arg1Of	expression,low
R2946	T3510	T3511	arg1Of	expression,of
R2947	T3514	T3515	arg1Of	CD40,","
R2948	T3515	T3518	arg1Of	",",and
R2949	T3516	T3515	arg2Of	CD80,","
R2950	T3518	T3511	arg2Of	and,of
R2951	T3518	T3512	arg1Of	and,co-stimulatory
R2952	T3518	T3513	arg1Of	and,molecules
R2953	T3518	T3517	arg1Of	and,","
R2954	T3519	T3518	arg2Of	CD86,and
R2955	T3524	T3521	arg1Of	I,TLR3
R2956	T3524	T3522	arg1Of	I,ligand
R2957	T3524	T3523	arg1Of	I,poly
R2958	T3524	T3525	arg1Of	I,:
R2959	T3526	T3520	arg1Of	C,The
R2960	T3526	T3524	arg1Of	C,I
R2961	T3526	T3527	arg1Of	C,and
R2962	T3527	T3533	arg1Of	and,activate
R2963	T3527	T3540	arg1Of	and,were
R2964	T3527	T3541	arg2Of	and,used
R2965	T3531	T3527	arg2Of	LPS,and
R2966	T3531	T3528	arg1Of	LPS,the
R2967	T3531	T3529	arg1Of	LPS,TLR4
R2968	T3531	T3530	arg1Of	LPS,ligand
R2969	T3533	T3532	arg1Of	activate,each
R2970	T3533	T3539	arg1Of	activate,and
R2971	T3534	T3535	arg1Of	overlapping,but
R2972	T3536	T3535	arg2Of	different,but
R2973	T3538	T3533	arg2Of	pathways,activate
R2974	T3538	T3534	arg1Of	pathways,overlapping
R2975	T3538	T3536	arg1Of	pathways,different
R2976	T3538	T3537	arg1Of	pathways,signaling
R2977	T3539	T3549	arg1Of	and,","
R2978	T3539	T3550	arg1Of	and,[
R2979	T3541	T3539	arg2Of	used,and
R2980	T3541	T3540	arg2Of	used,were
R2981	T3543	T3541	arg3Of	induce,used
R2982	T3543	T3542	arg1Of	induce,to
R2983	T3545	T3543	arg2Of	maturation,induce
R2984	T3545	T3544	arg1Of	maturation,DC
R2985	T3545	T3546	arg1Of	maturation,[
R2986	T3547	T3546	arg2Of	17,[
R2987	T3548	T3546	arg3Of	],[
R2988	T3551	T3550	arg2Of	18,[
R2989	T3552	T3550	arg3Of	],[
R2990	T3553	T3554	arg1Of	Incubation,with
R2991	T3553	T3561	arg1Of	Incubation,resulted
R2992	T3557	T3554	arg2Of	agonists,with
R2993	T3557	T3555	arg1Of	agonists,the
R2994	T3557	T3556	arg1Of	agonists,TLR
R2995	T3557	T3558	arg1Of	agonists,for
R2996	T3560	T3558	arg2Of	hours,for
R2997	T3560	T3559	arg1Of	hours,24
R2998	T3561	T3562	arg1Of	resulted,in
R2999	T3561	T3574	arg1Of	resulted,;
R3000	T3564	T3562	arg2Of	expression,in
R3001	T3564	T3563	arg2Of	expression,increased
R3002	T3564	T3565	arg1Of	expression,of
R3003	T3564	T3572	arg1Of	expression,on
R3004	T3566	T3567	arg1Of	CD40,","
R3005	T3567	T3570	arg1Of	",",and
R3006	T3568	T3567	arg2Of	CD80,","
R3007	T3570	T3565	arg2Of	and,of
R3008	T3570	T3569	arg1Of	and,","
R3009	T3571	T3570	arg2Of	CD86,and
R3010	T3573	T3572	arg2Of	BMDC,on
R3011	T3577	T3578	arg1Of	there,was
R3012	T3578	T3574	arg2Of	was,;
R3013	T3578	T3575	arg1Of	was,however
R3014	T3578	T3576	arg1Of	was,","
R3015	T3580	T3578	arg2Of	difference,was
R3016	T3580	T3579	arg1Of	difference,no
R3017	T3580	T3581	arg1Of	difference,in
R3018	T3580	T3588	arg1Of	difference,between
R3019	T3584	T3581	arg2Of	levels,in
R3020	T3584	T3582	arg1Of	levels,the
R3021	T3584	T3583	arg1Of	levels,expression
R3022	T3584	T3585	arg1Of	levels,of
R3023	T3587	T3585	arg2Of	markers,of
R3024	T3587	T3586	arg1Of	markers,these
R3025	T3589	T3590	arg1Of	WT,and
R3026	T3590	T3588	arg2Of	and,between
R3027	T3592	T3590	arg2Of	BMDC,and
R3028	T3592	T3591	arg1Of	BMDC,cpdm
R3029	T3592	T3593	arg1Of	BMDC,(
R3030	T3595	T3593	arg2Of	2B,(
R3031	T3595	T3594	arg1Of	2B,Fig.
R3032	T3596	T3593	arg3Of	),(
R3033	T3600	T3599	arg1Of	deficiency,SHARPIN
R3034	T3600	T3601	arg1Of	deficiency,did
R3035	T3600	T3603	arg1Of	deficiency,influence
R3036	T3603	T3597	arg1Of	influence,Thus
R3037	T3603	T3598	arg1Of	influence,","
R3038	T3603	T3601	arg2Of	influence,did
R3039	T3603	T3602	arg1Of	influence,not
R3040	T3605	T3603	arg2Of	expression,influence
R3041	T3605	T3604	arg1Of	expression,the
R3042	T3605	T3606	arg1Of	expression,of
R3043	T3605	T3609	arg1Of	expression,by
R3044	T3608	T3606	arg2Of	molecules,of
R3045	T3608	T3607	arg1Of	molecules,co-stimulatory
R3046	T3610	T3609	arg2Of	BMDC,by
R11269	T13537	T13538	arg1Of	Effect,of
R11270	T13537	T13541	arg1Of	Effect,on
R11271	T13540	T13538	arg2Of	mutation,of
R11272	T13540	T13539	arg1Of	mutation,Sharpin
R11273	T13543	T13542	arg1Of	subpopulations,DC
R11274	T13543	T13544	arg1Of	subpopulations,and
R11275	T13544	T13541	arg2Of	and,on
R11276	T13545	T13544	arg2Of	maturation,and
R11277	T13547	T13546	arg2Of	A,(
R11278	T13548	T13546	arg3Of	),(
R11279	T13549	T13546	arg1Of	Spleens,(
R11280	T13549	T13550	arg1Of	Spleens,from
R11281	T13549	T13555	arg1Of	Spleens,were
R11282	T13549	T13556	arg2Of	Spleens,isolated
R11283	T13549	T13558	arg1Of	Spleens,subject
R11284	T13551	T13552	arg1Of	WT,and
R11285	T13553	T13552	arg2Of	cpdm,and
R11286	T13554	T13550	arg2Of	mice,from
R11287	T13554	T13551	arg1Of	mice,WT
R11288	T13554	T13553	arg1Of	mice,cpdm
R11289	T13556	T13557	arg1Of	isolated,and
R11290	T13557	T13555	arg2Of	and,were
R11291	T13558	T13557	arg2Of	subject,and
R11292	T13558	T13559	arg1Of	subject,to
R11293	T13560	T13561	arg1Of	collagenase,and
R11294	T13561	T13559	arg2Of	and,to
R11295	T13563	T13561	arg2Of	digestion,and
R11296	T13563	T13562	arg1Of	digestion,DNase
R11297	T13567	T13564	arg1Of	homogenates,The
R11298	T13567	T13565	arg2Of	homogenates,obtained
R11299	T13567	T13566	arg1Of	homogenates,splenic
R11300	T13567	T13568	arg1Of	homogenates,were
R11301	T13567	T13569	arg2Of	homogenates,centrifuged
R11302	T13569	T13568	arg2Of	centrifuged,were
R11303	T13569	T13570	arg1Of	centrifuged,over
R11304	T13573	T13570	arg2Of	gradient,over
R11305	T13573	T13571	arg1Of	gradient,a
R11306	T13573	T13572	arg1Of	gradient,Percoll
R11307	T13573	T13574	arg1Of	gradient,(
R11308	T13573	T13582	arg1Of	gradient,for
R11309	T13576	T13575	arg1Of	%,35
R11310	T13576	T13577	arg1Of	%,and
R11311	T13577	T13579	arg1Of	and,%
R11312	T13578	T13577	arg2Of	55,and
R11313	T13580	T13574	arg2Of	density,(
R11314	T13580	T13576	arg1Of	density,%
R11315	T13580	T13578	arg1Of	density,55
R11316	T13581	T13574	arg3Of	),(
R11317	T13584	T13582	arg2Of	minutes,for
R11318	T13584	T13583	arg1Of	minutes,15
R11319	T13586	T13585	arg1Of	bands,The
R11320	T13586	T13587	arg1Of	bands,at
R11321	T13586	T13597	arg1Of	bands,were
R11322	T13586	T13598	arg2Of	bands,pooled
R11323	T13586	T13600	arg2Of	bands,washed
R11324	T13586	T13602	arg2Of	bands,stained
R11325	T13589	T13590	arg1Of	35,%
R11326	T13591	T13588	arg1Of	-medium,the
R11327	T13591	T13589	arg1Of	-medium,35
R11328	T13591	T13592	arg1Of	-medium,and
R11329	T13592	T13587	arg2Of	and,at
R11330	T13594	T13595	arg1Of	35–55,%
R11331	T13596	T13592	arg2Of	interface,and
R11332	T13596	T13593	arg1Of	interface,the
R11333	T13596	T13594	arg1Of	interface,35–55
R11334	T13598	T13599	arg1Of	pooled,","
R11335	T13599	T13601	arg1Of	",",and
R11336	T13600	T13599	arg2Of	washed,","
R11337	T13601	T13597	arg2Of	and,were
R11338	T13602	T13601	arg2Of	stained,and
R11339	T13602	T13603	arg1Of	stained,with
R11340	T13605	T13603	arg2Of	combination,with
R11341	T13605	T13604	arg1Of	combination,a
R11342	T13605	T13606	arg1Of	combination,of
R11343	T13605	T13609	modOf	combination,to
R11344	T13605	T13628	modOf	combination,were
R11345	T13608	T13606	arg2Of	antibodies,of
R11346	T13608	T13607	arg1Of	antibodies,various
R11347	T13610	T13609	arg1Of	stain,to
R11348	T13613	T13610	arg2Of	subsets,stain
R11349	T13613	T13611	arg1Of	subsets,different
R11350	T13613	T13612	arg1Of	subsets,DC
R11351	T13613	T13614	arg1Of	subsets,","
R11352	T13616	T13617	arg1Of	CD11c+CD8α+,","
R11353	T13617	T13619	arg1Of	",",and
R11354	T13618	T13617	arg2Of	CD11c+CD8α−,","
R11355	T13619	T13614	arg2Of	and,","
R11356	T13619	T13615	arg1Of	and,conventional
R11357	T13621	T13619	arg2Of	DC,and
R11358	T13621	T13620	arg1Of	DC,plasmacytoid
R11359	T13623	T13622	arg2Of	CD11c−PDCA-1+,(
R11360	T13624	T13622	arg3Of	),(
R11361	T13627	T13622	arg1Of	panels,(
R11362	T13627	T13625	arg1Of	panels,.The
R11363	T13627	T13626	arg1Of	panels,top
R11364	T13627	T13628	arg1Of	panels,were
R11365	T13627	T13629	arg2Of	panels,gated
R11366	T13629	T13628	arg2Of	gated,were
R11367	T13629	T13630	arg1Of	gated,on
R11368	T13629	T13633	modOf	gated,to
R11369	T13632	T13630	arg2Of	cells,on
R11370	T13632	T13631	arg1Of	cells,FSChiSSClo
R11371	T13634	T13633	arg1Of	show,to
R11372	T13636	T13634	arg2Of	populations,show
R11373	T13636	T13635	arg1Of	populations,separate
R11374	T13636	T13637	arg1Of	populations,of
R11375	T13638	T13639	arg1Of	CD11c+PDCA-1−,and
R11376	T13640	T13639	arg2Of	CD11c−PDCA-1+,and
R11377	T13641	T13637	arg2Of	cells,of
R11378	T13641	T13638	arg1Of	cells,CD11c+PDCA-1−
R11379	T13641	T13640	arg1Of	cells,CD11c−PDCA-1+
R11380	T13643	T13642	arg1Of	gating,Further
R11381	T13643	T13644	arg1Of	gating,on
R11382	T13643	T13648	arg1Of	gating,gave
R11383	T13647	T13644	arg2Of	subpopulation,on
R11384	T13647	T13645	arg1Of	subpopulation,the
R11385	T13647	T13646	arg1Of	subpopulation,CD11c+PDCA-1−
R11386	T13651	T13648	arg2Of	panel,gave
R11387	T13651	T13649	arg1Of	panel,the
R11388	T13651	T13650	arg1Of	panel,bottom
R11389	T13652	T13648	arg3Of	that,gave
R11390	T13652	T13653	arg1Of	that,showed
R11391	T13656	T13653	arg2Of	pools,showed
R11392	T13656	T13654	arg1Of	pools,two
R11393	T13656	T13655	arg1Of	pools,distinct
R11394	T13656	T13657	arg1Of	pools,of
R11395	T13661	T13657	arg2Of	cells,of
R11396	T13661	T13658	arg1Of	cells,CD11c+CD8α+
R11397	T13661	T13659	arg1Of	cells,and
R11398	T13661	T13660	arg1Of	cells,CD11c+CD8α−
R11399	T13662	T13663	arg1Of	Percentages,were
R11400	T13662	T13664	arg2Of	Percentages,calculated
R11401	T13662	T13671	arg1Of	Percentages,were
R11402	T13662	T13673	arg2Of	Percentages,shown
R11403	T13664	T13663	arg2Of	calculated,were
R11404	T13664	T13665	arg1Of	calculated,based
R11405	T13664	T13670	arg1Of	calculated,and
R11406	T13666	T13665	arg2Of	on,based
R11407	T13669	T13666	arg2Of	population,on
R11408	T13669	T13667	arg1Of	population,the
R11409	T13669	T13668	arg1Of	population,parental
R11410	T13673	T13670	arg2Of	shown,and
R11411	T13673	T13671	arg2Of	shown,were
R11412	T13673	T13672	arg1Of	shown,additionally
R11413	T13673	T13674	arg1Of	shown,as
R11414	T13673	T13680	arg1Of	shown,(
R11415	T13673	T13708	arg1Of	shown,5
R11416	T13676	T13674	arg2Of	graphs,as
R11417	T13676	T13675	arg1Of	graphs,bar
R11418	T13676	T13677	arg1Of	graphs,(
R11419	T13678	T13677	arg2Of	n = 2,(
R11420	T13679	T13677	arg3Of	),(
R11421	T13681	T13680	arg2Of	B,(
R11422	T13682	T13680	arg3Of	),(
R11423	T13684	T13683	arg2Of	(,.
R11424	T13685	T13683	arg3Of	C,.
R11425	T13686	T13683	arg1Of	) ,.
R11426	T13686	T13687	arg1Of	) ,WT
R11427	T13687	T13673	arg3Of	WT ,shown
R11428	T13687	T13694	modOf	WT ,cell
R11429	T13687	T13707	arg1Of	WT ,2
R11430	T13689	T13687	arg2Of	cpdm,WT
R11431	T13689	T13688	arg1Of	cpdm,and
R11432	T13689	T13690	arg1Of	cpdm,B
R11433	T13691	T13690	arg2Of	MDC (,B
R11434	T13692	T13690	arg3Of	5,B
R11435	T13693	T13694	arg1Of	×105),cell
R11436	T13693	T13695	arg2Of	×105),s were sti
R11437	T13695	T13694	arg2Of	s were sti,cell
R11438	T13695	T13696	arg1Of	s were sti,mula
R11439	T13697	T13698	arg1Of	ted wi,t
R11440	T13698	T13702	arg1Of	t,00
R11441	T13699	T13700	arg1Of	h m,edium
R11442	T13701	T13698	arg2Of	", 1",t
R11443	T13701	T13699	arg1Of	", 1",h m
R11444	T13702	T13696	arg2Of	00,mula
R11445	T13706	T13702	arg2Of	r,00
R11446	T13706	T13703	arg1Of	r,ng
R11447	T13706	T13704	arg1Of	r,/ml L
R11448	T13706	T13705	arg1Of	r,PS o
R11449	T13708	T13709	arg1Of	5,µg/
R11450	T13711	T13709	arg2Of	poly ,µg/
R11451	T13711	T13710	arg1Of	poly ,ml
R11452	T13713	T13712	arg1Of	cells,The
R11453	T13713	T13714	arg1Of	cells,were
R11454	T13713	T13715	arg2Of	cells,labeled
R11455	T13713	T13726	arg2Of	cells,subjected
R11456	T13713	T13728	arg1Of	cells,flow
R11457	T13715	T13716	arg1Of	labeled,with
R11458	T13715	T13725	arg1Of	labeled,and
R11459	T13718	T13717	arg1Of	anti-CD40,PE-labeled
R11460	T13718	T13719	arg1Of	anti-CD40,","
R11461	T13719	T13722	arg1Of	",",and
R11462	T13720	T13719	arg2Of	anti-CD80,","
R11463	T13722	T13716	arg2Of	and,with
R11464	T13722	T13721	arg1Of	and,","
R11465	T13723	T13722	arg2Of	anti-CD86,and
R11466	T13725	T13714	arg2Of	and,were
R11467	T13725	T13724	arg1Of	and,","
R11468	T13726	T13725	arg2Of	subjected,and
R11469	T13728	T13726	arg3Of	flow,subjected
R11470	T13728	T13727	arg1Of	flow,to
R11471	T13730	T13728	arg2Of	analysis,flow
R11472	T13730	T13729	arg1Of	analysis,cytometry
R11473	T13732	T13731	arg1Of	populations,The
R11474	T13732	T13733	arg2Of	populations,shown
R11475	T13732	T13736	arg1Of	populations,were
R11476	T13732	T13737	arg2Of	populations,gated
R11477	T13733	T13734	arg1Of	shown,in
R11478	T13735	T13734	arg2Of	histograms,in
R11479	T13737	T13736	arg2Of	gated,were
R11480	T13737	T13738	arg1Of	gated,on
R11481	T13740	T13738	arg2Of	cells,on
R11482	T13740	T13739	arg1Of	cells,CD11c+
R11483	T13742	T13741	arg1Of	cells,Unstained
R11484	T13742	T13743	arg1Of	cells,served
R11485	T13743	T13744	arg1Of	served,as
R11486	T13746	T13744	arg2Of	controls,as
R11487	T13746	T13745	arg1Of	controls,negative
R11488	T13747	T13748	arg1Of	Results,are
R11489	T13747	T13749	arg1Of	Results,representative
R11490	T13749	T13748	arg2Of	representative,are
R11491	T13749	T13750	arg1Of	representative,of
R11492	T13753	T13750	arg2Of	experiments,of
R11493	T13753	T13751	arg1Of	experiments,two
R11494	T13753	T13752	arg1Of	experiments,independent
R2713	T3289	T3288	arg2Of	cpdm,and
R2714	T3290	T3289	arg1Of	mice,cpdm

bionlp-st-ge-2016-coref

Id	Subject	Object	Predicate	Lexical cue
T3611	2954-2967	Anaphor	denotes	these markers
T3612	2863-2867	Antecedent	denotes	CD40
T3613	2869-2873	Antecedent	denotes	CD80
T3614	2879-2883	Antecedent	denotes	CD86
R3047	T3611	T3612	boundBy	these markers,CD40
R3048	T3611	T3613	boundBy	these markers,CD80
R3049	T3611	T3614	boundBy	these markers,CD86

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T2885	0-11	VBG	denotes	Phenotyping
T2886	12-19	JJ	denotes	splenic
T2887	20-22	NNP	denotes	DC
T2888	23-26	CC	denotes	and
T2889	27-31	NNP	denotes	BMDC
T2890	32-36	IN	denotes	from
T2891	37-39	NNP	denotes	WT
T2892	40-43	CC	denotes	and
T2893	44-48	NN	denotes	cpdm
T2894	49-53	NNS	denotes	mice
T2895	54-56	NNP	denotes	DC
T2896	57-60	VBP	denotes	are
T2897	61-74	JJ	denotes	heterogeneous
T2898	75-78	CC	denotes	and
T2899	79-82	MD	denotes	can
T2900	83-85	VB	denotes	be
T2901	86-97	VBN	denotes	categorized
T2902	98-102	IN	denotes	into
T2903	103-111	JJ	denotes	multiple
T2904	112-120	NNS	denotes	subtypes
T2905	121-126	VBN	denotes	based
T2906	127-129	IN	denotes	on
T2907	130-137	NN	denotes	surface
T2908	138-145	NNS	denotes	markers
T2909	146-147	NNP	denotes	[
T2910	147-149	CD	denotes	13
T2911	149-150	NNP	denotes	]
T2912	150-151	.	denotes	.
T2913	152-154	TO	denotes	To
T2914	155-164	VB	denotes	determine
T2915	165-167	IN	denotes	if
T2916	168-171	DT	denotes	the
T2917	172-179	NNP	denotes	Sharpin
T2918	180-188	NN	denotes	mutation
T2919	189-196	VBZ	denotes	affects
T2920	197-199	NNP	denotes	DC
T2921	200-211	NN	denotes	development
T2922	212-214	IN	denotes	in
T2923	215-223	JJ	denotes	lymphoid
T2924	224-231	NNS	denotes	tissues
T2925	231-232	,	denotes	,
T2926	233-238	NN	denotes	mouse
T2927	239-246	NNS	denotes	spleens
T2928	247-251	VBD	denotes	were
T2929	252-260	VBN	denotes	examined
T2930	261-264	IN	denotes	for
T2931	265-268	DT	denotes	the
T2932	269-281	NN	denotes	distribution
T2933	282-284	IN	denotes	of
T2934	285-297	JJ	denotes	conventional
T2935	298-300	NNP	denotes	DC
T2936	301-302	-LRB-	denotes	(
T2937	302-305	NNP	denotes	cDC
T2938	305-306	:	denotes	;
T2939	307-312	NNP	denotes	CD11c
T2940	312-313	NNP	denotes	+
T2941	313-317	NNP	denotes	CD8α
T2942	317-318	NN	denotes	+
T2943	319-322	CC	denotes	and
T2944	323-328	JJ	denotes	CD11c
T2945	328-329	NN	denotes	+
T2946	329-333	NNP	denotes	CD8α
T2947	333-334	NNP	denotes	−
T2948	334-335	-RRB-	denotes	)
T2949	336-337	NNP	denotes	[
T2950	337-339	CD	denotes	13
T2951	339-340	NNP	denotes	]
T2952	341-344	CC	denotes	and
T2953	345-357	JJ	denotes	plasmacytoid
T2954	358-360	NNP	denotes	DC
T2955	361-362	-LRB-	denotes	(
T2956	362-365	NNP	denotes	pDC
T2957	365-366	:	denotes	;
T2958	367-372	NNP	denotes	CD11c
T2959	372-373	NNP	denotes	−
T2960	373-379	NNP	denotes	PDCA-1
T2961	379-380	NNP	denotes	+
T2962	380-381	-RRB-	denotes	)
T2963	382-383	NNP	denotes	[
T2964	383-385	CD	denotes	14
T2965	385-386	NNP	denotes	]
T2966	386-387	.	denotes	.
T2967	388-391	DT	denotes	The
T2968	392-403	NNS	denotes	percentages
T2969	404-407	IN	denotes	for
T2970	408-415	JJ	denotes	splenic
T2971	416-419	NNP	denotes	cDC
T2972	420-423	CC	denotes	and
T2973	424-427	NNP	denotes	pDC
T2974	428-432	VBD	denotes	were
T2975	433-437	DT	denotes	both
T2976	438-445	VBN	denotes	reduced
T2977	446-448	IN	denotes	in
T2978	449-453	NN	denotes	cpdm
T2979	454-458	NNS	denotes	mice
T2980	459-463	WRB	denotes	when
T2981	464-472	VBN	denotes	compared
T2982	473-477	IN	denotes	with
T2983	478-480	NNP	denotes	WT
T2984	481-489	NNS	denotes	controls
T2985	490-491	-LRB-	denotes	(
T2986	491-495	NNP	denotes	Fig.
T2987	496-498	NNP	denotes	2A
T2988	498-499	-RRB-	denotes	)
T2989	499-500	.	denotes	.
T2990	501-508	RB	denotes	However
T2991	508-509	,	denotes	,
T2992	510-514	WRB	denotes	when
T2993	515-520	VBN	denotes	gated
T2994	521-523	IN	denotes	on
T2995	524-529	JJ	denotes	CD11c
T2996	529-530	NN	denotes	+
T2997	531-534	NNP	denotes	cDC
T2998	534-535	,	denotes	,
T2999	536-539	DT	denotes	the
T3000	540-551	NNS	denotes	percentages
T3001	552-554	IN	denotes	of
T3002	555-559	JJ	denotes	CD8α
T3003	559-560	NN	denotes	+
T3004	561-564	CC	denotes	and
T3005	565-569	JJ	denotes	CD8α
T3006	569-570	NN	denotes	−
T3007	571-576	NNS	denotes	cells
T3008	577-581	VBD	denotes	were
T3009	582-585	RB	denotes	not
T3010	586-594	VBN	denotes	affected
T3011	595-597	IN	denotes	by
T3012	598-605	NNP	denotes	SHARPIN
T3013	606-616	NN	denotes	deficiency
T3014	617-618	-LRB-	denotes	(
T3015	618-622	NNP	denotes	Fig.
T3016	623-625	NNP	denotes	2A
T3017	625-626	-RRB-	denotes	)
T3018	626-627	.	denotes	.
T3019	628-633	IN	denotes	Since
T3020	634-637	DT	denotes	the
T3021	638-644	NN	denotes	spleen
T3022	645-647	IN	denotes	of
T3023	648-652	NN	denotes	cpdm
T3024	653-657	NNS	denotes	mice
T3025	658-660	VBZ	denotes	is
T3026	661-669	RB	denotes	markedly
T3027	670-678	JJ	denotes	enlarged
T3028	679-682	CC	denotes	and
T3029	683-691	VBZ	denotes	contains
T3030	692-697	CD	denotes	three
T3031	698-703	NNS	denotes	times
T3032	704-706	IN	denotes	as
T3033	707-711	JJ	denotes	many
T3034	712-717	NNS	denotes	cells
T3035	718-719	-LRB-	denotes	(
T3036	719-723	NNP	denotes	Fig.
T3037	724-726	NNP	denotes	1C
T3038	726-727	-RRB-	denotes	)
T3039	727-728	,	denotes	,
T3040	729-732	DT	denotes	the
T3041	733-742	JJ	denotes	different
T3042	743-754	NNS	denotes	percentages
T3043	755-757	IN	denotes	of
T3044	758-765	JJ	denotes	splenic
T3045	766-769	NNP	denotes	cDC
T3046	770-773	CC	denotes	and
T3047	774-777	NNP	denotes	pDC
T3048	778-785	IN	denotes	between
T3049	786-788	NNP	denotes	WT
T3050	789-792	CC	denotes	and
T3051	793-799	JJ	denotes	mutant
T3052	800-804	NNS	denotes	mice
T3053	805-812	VBP	denotes	reflect
T3054	813-816	DT	denotes	the
T3055	817-826	VBN	denotes	increased
T3056	827-833	NN	denotes	number
T3057	834-836	IN	denotes	of
T3058	837-842	JJ	denotes	total
T3059	843-849	JJ	denotes	spleen
T3060	850-855	NNS	denotes	cells
T3061	856-862	RB	denotes	rather
T3062	863-867	IN	denotes	than
T3063	868-869	DT	denotes	a
T3064	870-879	NN	denotes	reduction
T3065	880-882	IN	denotes	in
T3066	883-886	NNP	denotes	cDC
T3067	887-890	CC	denotes	and
T3068	891-894	NNP	denotes	pDC
T3069	895-902	NNS	denotes	numbers
T3070	902-903	.	denotes	.
T3071	904-909	DT	denotes	These
T3072	910-914	NNS	denotes	data
T3073	915-923	VBP	denotes	indicate
T3074	924-928	IN	denotes	that
T3075	929-932	DT	denotes	the
T3076	933-940	NNP	denotes	Sharpin
T3077	941-949	NN	denotes	mutation
T3078	950-954	VBZ	denotes	does
T3079	955-958	RB	denotes	not
T3080	959-965	VB	denotes	affect
T3081	966-969	DT	denotes	the
T3082	970-982	NN	denotes	distribution
T3083	983-985	IN	denotes	of
T3084	986-989	DT	denotes	the
T3085	990-998	VBN	denotes	examined
T3086	999-1001	NNP	denotes	DC
T3087	1002-1009	NNS	denotes	subsets
T3088	1010-1012	IN	denotes	in
T3089	1013-1016	DT	denotes	the
T3090	1017-1023	NN	denotes	spleen
T3091	1023-1024	.	denotes	.
T3092	2347-2351	NNP	denotes	BMDC
T3093	2352-2356	IN	denotes	from
T3094	2357-2359	IN	denotes	in
T3095	2360-2365	NN	denotes	vitro
T3096	2366-2374	NNS	denotes	cultures
T3097	2375-2387	RB	denotes	functionally
T3098	2388-2396	VBP	denotes	resemble
T3099	2397-2409	JJ	denotes	non-lymphoid
T3100	2410-2416	NN	denotes	tissue
T3101	2417-2419	NNP	denotes	DC
T3102	2420-2423	CC	denotes	and
T3103	2424-2440	JJ	denotes	monocyte-derived
T3104	2441-2453	JJ	denotes	inflammatory
T3105	2454-2456	NNP	denotes	DC
T3106	2457-2458	NNP	denotes	[
T3107	2458-2460	CD	denotes	15
T3108	2460-2461	NNP	denotes	]
T3109	2461-2462	,	denotes	,
T3110	2463-2464	NNP	denotes	[
T3111	2464-2466	CD	denotes	16
T3112	2466-2467	NNP	denotes	]
T3113	2467-2468	.	denotes	.
T3114	2469-2472	DT	denotes	The
T3115	2473-2479	NNS	denotes	yields
T3116	2480-2482	IN	denotes	of
T3117	2483-2487	NNP	denotes	BMDC
T3118	2488-2492	IN	denotes	from
T3119	2493-2495	NNP	denotes	WT
T3120	2496-2499	CC	denotes	and
T3121	2500-2504	NN	denotes	cpdm
T3122	2505-2509	NNS	denotes	mice
T3123	2510-2514	VBD	denotes	were
T3124	2515-2522	JJ	denotes	similar
T3125	2522-2523	.	denotes	.
T3126	2524-2528	NNP	denotes	BMDC
T3127	2529-2533	VBD	denotes	were
T3128	2534-2539	JJ	denotes	CD11c
T3129	2539-2540	NN	denotes	+
T3130	2541-2544	CC	denotes	and
T3131	2545-2548	NNP	denotes	MHC
T3132	2549-2551	NNP	denotes	II
T3133	2551-2552	NN	denotes	+
T3134	2553-2557	IN	denotes	with
T3135	2558-2561	JJ	denotes	low
T3136	2562-2572	NN	denotes	expression
T3137	2573-2575	IN	denotes	of
T3138	2576-2590	JJ	denotes	co-stimulatory
T3139	2591-2600	NNS	denotes	molecules
T3140	2601-2605	NNP	denotes	CD40
T3141	2605-2606	,	denotes	,
T3142	2607-2611	NNP	denotes	CD80
T3143	2611-2612	,	denotes	,
T3144	2613-2616	CC	denotes	and
T3145	2617-2621	NNP	denotes	CD86
T3146	2621-2622	.	denotes	.
T3147	2623-2626	DT	denotes	The
T3148	2627-2631	CD	denotes	TLR3
T3149	2632-2638	NN	denotes	ligand
T3150	2639-2643	NN	denotes	poly
T3151	2644-2645	PRP	denotes	I
T3152	2645-2646	:	denotes	:
T3153	2646-2647	NNP	denotes	C
T3154	2648-2651	CC	denotes	and
T3155	2652-2655	DT	denotes	the
T3156	2656-2660	CD	denotes	TLR4
T3157	2661-2667	NN	denotes	ligand
T3158	2668-2671	NNP	denotes	LPS
T3159	2672-2676	DT	denotes	each
T3160	2677-2685	VBP	denotes	activate
T3161	2686-2697	VBG	denotes	overlapping
T3162	2698-2701	CC	denotes	but
T3163	2702-2711	JJ	denotes	different
T3164	2712-2721	VBG	denotes	signaling
T3165	2722-2730	NNS	denotes	pathways
T3166	2731-2734	CC	denotes	and
T3167	2735-2739	VBD	denotes	were
T3168	2740-2744	VBN	denotes	used
T3169	2745-2747	TO	denotes	to
T3170	2748-2754	VB	denotes	induce
T3171	2755-2757	NNP	denotes	DC
T3172	2758-2768	NN	denotes	maturation
T3173	2769-2770	NNP	denotes	[
T3174	2770-2772	CD	denotes	17
T3175	2772-2773	NNP	denotes	]
T3176	2773-2774	,	denotes	,
T3177	2775-2776	NNP	denotes	[
T3178	2776-2778	CD	denotes	18
T3179	2778-2779	NNP	denotes	]
T3180	2779-2780	.	denotes	.
T3181	2781-2791	NNP	denotes	Incubation
T3182	2792-2796	IN	denotes	with
T3183	2797-2800	DT	denotes	the
T3184	2801-2804	NNP	denotes	TLR
T3185	2805-2813	NNS	denotes	agonists
T3186	2814-2817	IN	denotes	for
T3187	2818-2820	CD	denotes	24
T3188	2821-2826	NNS	denotes	hours
T3189	2827-2835	VBD	denotes	resulted
T3190	2836-2838	IN	denotes	in
T3191	2839-2848	VBN	denotes	increased
T3192	2849-2859	NN	denotes	expression
T3193	2860-2862	IN	denotes	of
T3194	2863-2867	NNP	denotes	CD40
T3195	2867-2868	,	denotes	,
T3196	2869-2873	NNP	denotes	CD80
T3197	2873-2874	,	denotes	,
T3198	2875-2878	CC	denotes	and
T3199	2879-2883	NNP	denotes	CD86
T3200	2884-2886	IN	denotes	on
T3201	2887-2891	NNP	denotes	BMDC
T3202	2891-2892	:	denotes	;
T3203	2893-2900	RB	denotes	however
T3204	2900-2901	,	denotes	,
T3205	2902-2907	EX	denotes	there
T3206	2908-2911	VBD	denotes	was
T3207	2912-2914	DT	denotes	no
T3208	2915-2925	NN	denotes	difference
T3209	2926-2928	IN	denotes	in
T3210	2929-2932	DT	denotes	the
T3211	2933-2943	NN	denotes	expression
T3212	2944-2950	NNS	denotes	levels
T3213	2951-2953	IN	denotes	of
T3214	2954-2959	DT	denotes	these
T3215	2960-2967	NNS	denotes	markers
T3216	2968-2975	IN	denotes	between
T3217	2976-2978	NNP	denotes	WT
T3218	2979-2982	CC	denotes	and
T3219	2983-2987	VB	denotes	cpdm
T3220	2988-2992	NNP	denotes	BMDC
T3221	2993-2994	-LRB-	denotes	(
T3222	2994-2998	NNP	denotes	Fig.
T3223	2999-3001	NNP	denotes	2B
T3224	3001-3002	-RRB-	denotes	)
T3225	3002-3003	.	denotes	.
T3226	3004-3008	RB	denotes	Thus
T3227	3008-3009	,	denotes	,
T3228	3010-3017	NNP	denotes	SHARPIN
T3229	3018-3028	NN	denotes	deficiency
T3230	3029-3032	VBD	denotes	did
T3231	3033-3036	RB	denotes	not
T3232	3037-3046	VB	denotes	influence
T3233	3047-3050	DT	denotes	the
T3234	3051-3061	NN	denotes	expression
T3235	3062-3064	IN	denotes	of
T3236	3065-3079	JJ	denotes	co-stimulatory
T3237	3080-3089	NNS	denotes	molecules
T3238	3090-3092	IN	denotes	by
T3239	3093-3097	NNP	denotes	BMDC
T3240	3097-3098	.	denotes	.
T13275	1069-1075	NN	denotes	Effect
T13276	1076-1078	IN	denotes	of
T13277	1079-1086	NNP	denotes	Sharpin
T13278	1087-1095	NN	denotes	mutation
T13279	1096-1098	IN	denotes	on
T13280	1099-1101	NNP	denotes	DC
T13281	1102-1116	NNS	denotes	subpopulations
T13282	1117-1120	CC	denotes	and
T13283	1121-1131	NN	denotes	maturation
T13284	1131-1132	.	denotes	.
T13285	1133-1134	-LRB-	denotes	(
T13286	1134-1135	NNP	denotes	A
T13287	1135-1136	-RRB-	denotes	)
T13288	1137-1144	NNP	denotes	Spleens
T13289	1145-1149	IN	denotes	from
T13290	1150-1152	NNP	denotes	WT
T13291	1153-1156	CC	denotes	and
T13292	1157-1161	NN	denotes	cpdm
T13293	1162-1166	NNS	denotes	mice
T13294	1167-1171	VBD	denotes	were
T13295	1172-1180	VBN	denotes	isolated
T13296	1181-1184	CC	denotes	and
T13297	1185-1192	JJ	denotes	subject
T13298	1193-1195	TO	denotes	to
T13299	1196-1207	VB	denotes	collagenase
T13300	1208-1211	CC	denotes	and
T13301	1212-1217	VB	denotes	DNase
T13302	1218-1227	NN	denotes	digestion
T13303	1227-1228	.	denotes	.
T13304	1229-1232	DT	denotes	The
T13305	1233-1241	VBN	denotes	obtained
T13306	1242-1249	JJ	denotes	splenic
T13307	1250-1261	NNS	denotes	homogenates
T13308	1262-1266	VBD	denotes	were
T13309	1267-1278	VBN	denotes	centrifuged
T13310	1279-1283	IN	denotes	over
T13311	1284-1285	DT	denotes	a
T13312	1286-1293	NNP	denotes	Percoll
T13313	1294-1302	NN	denotes	gradient
T13314	1303-1304	-LRB-	denotes	(
T13315	1304-1306	CD	denotes	35
T13316	1306-1307	NN	denotes	%
T13317	1308-1311	CC	denotes	and
T13318	1312-1314	CD	denotes	55
T13319	1314-1315	NN	denotes	%
T13320	1316-1323	NN	denotes	density
T13321	1323-1324	-RRB-	denotes	)
T13322	1325-1328	IN	denotes	for
T13323	1329-1331	CD	denotes	15
T13324	1332-1339	NNS	denotes	minutes
T13325	1339-1340	.	denotes	.
T13326	1341-1344	DT	denotes	The
T13327	1345-1350	NNS	denotes	bands
T13328	1351-1353	IN	denotes	at
T13329	1354-1357	DT	denotes	the
T13330	1358-1360	CD	denotes	35
T13331	1360-1361	NN	denotes	%
T13332	1361-1362	:	denotes	-
T13333	1362-1368	NN	denotes	medium
T13334	1369-1372	CC	denotes	and
T13335	1373-1376	DT	denotes	the
T13336	1377-1379	CD	denotes	35
T13337	1380-1382	CD	denotes	55
T13338	1382-1383	NN	denotes	%
T13339	1384-1393	NN	denotes	interface
T13340	1394-1398	VBD	denotes	were
T13341	1399-1405	VBN	denotes	pooled
T13342	1405-1406	,	denotes	,
T13343	1407-1413	VBN	denotes	washed
T13344	1414-1417	CC	denotes	and
T13345	1418-1425	VBN	denotes	stained
T13346	1426-1430	IN	denotes	with
T13347	1431-1432	DT	denotes	a
T13348	1433-1444	NN	denotes	combination
T13349	1445-1447	IN	denotes	of
T13350	1448-1455	JJ	denotes	various
T13351	1456-1466	NNS	denotes	antibodies
T13352	1467-1469	TO	denotes	to
T13353	1470-1475	VB	denotes	stain
T13354	1476-1485	JJ	denotes	different
T13355	1486-1488	NN	denotes	DC
T13356	1489-1496	NNS	denotes	subsets
T13357	1496-1497	,	denotes	,
T13358	1498-1510	JJ	denotes	conventional
T13359	1511-1516	JJ	denotes	CD11c
T13360	1516-1517	NN	denotes	+
T13361	1517-1521	NNP	denotes	CD8α
T13362	1521-1522	NNP	denotes	+
T13363	1522-1523	,	denotes	,
T13364	1524-1529	NNP	denotes	CD11c
T13365	1529-1530	NNP	denotes	+
T13366	1530-1534	NNP	denotes	CD8α
T13367	1534-1535	NNP	denotes	−
T13368	1536-1539	CC	denotes	and
T13369	1540-1552	JJ	denotes	plasmacytoid
T13370	1553-1555	NNP	denotes	DC
T13371	1556-1557	-LRB-	denotes	(
T13372	1557-1562	NNP	denotes	CD11c
T13373	1562-1563	NNP	denotes	−
T13374	1563-1569	NNP	denotes	PDCA-1
T13375	1569-1570	NNP	denotes	+
T13376	1570-1571	-RRB-	denotes	)
T13377	1571-1572	.	denotes	.
T13378	1572-1575	DT	denotes	The
T13379	1576-1579	JJ	denotes	top
T13380	1580-1586	NNS	denotes	panels
T13381	1587-1591	VBD	denotes	were
T13382	1592-1597	VBN	denotes	gated
T13383	1598-1600	IN	denotes	on
T13384	1601-1611	NNP	denotes	FSChiSSClo
T13385	1612-1617	NNS	denotes	cells
T13386	1618-1620	TO	denotes	to
T13387	1621-1625	VB	denotes	show
T13388	1626-1634	JJ	denotes	separate
T13389	1635-1646	NNS	denotes	populations
T13390	1647-1649	IN	denotes	of
T13391	1650-1655	JJ	denotes	CD11c
T13392	1655-1656	NN	denotes	+
T13393	1656-1662	NN	denotes	PDCA-1
T13394	1662-1663	NN	denotes	−
T13395	1664-1667	CC	denotes	and
T13396	1668-1673	JJ	denotes	CD11c
T13397	1673-1674	NN	denotes	−
T13398	1674-1680	NN	denotes	PDCA-1
T13399	1680-1681	NN	denotes	+
T13400	1682-1687	NNS	denotes	cells
T13401	1687-1688	.	denotes	.
T13402	1689-1696	JJ	denotes	Further
T13403	1697-1703	NN	denotes	gating
T13404	1704-1706	IN	denotes	on
T13405	1707-1710	DT	denotes	the
T13406	1711-1716	JJ	denotes	CD11c
T13407	1716-1717	NN	denotes	+
T13408	1717-1723	NN	denotes	PDCA-1
T13409	1723-1724	NN	denotes	−
T13410	1725-1738	NN	denotes	subpopulation
T13411	1739-1743	VBD	denotes	gave
T13412	1744-1747	DT	denotes	the
T13413	1748-1754	JJ	denotes	bottom
T13414	1755-1760	NN	denotes	panel
T13415	1761-1765	WDT	denotes	that
T13416	1766-1772	VBD	denotes	showed
T13417	1773-1776	CD	denotes	two
T13418	1777-1785	JJ	denotes	distinct
T13419	1786-1791	NNS	denotes	pools
T13420	1792-1794	IN	denotes	of
T13421	1795-1800	JJ	denotes	CD11c
T13422	1800-1801	NN	denotes	+
T13423	1801-1805	NNP	denotes	CD8α
T13424	1805-1806	NNP	denotes	+
T13425	1807-1810	CC	denotes	and
T13426	1811-1816	NNP	denotes	CD11c
T13427	1816-1817	VBP	denotes	+
T13428	1817-1821	JJ	denotes	CD8α
T13429	1821-1822	NN	denotes	−
T13430	1823-1828	NNS	denotes	cells
T13431	1828-1829	.	denotes	.
T13432	1830-1841	NNS	denotes	Percentages
T13433	1842-1846	VBD	denotes	were
T13434	1847-1857	VBN	denotes	calculated
T13435	1858-1863	VBN	denotes	based
T13436	1864-1866	IN	denotes	on
T13437	1867-1870	DT	denotes	the
T13438	1871-1879	JJ	denotes	parental
T13439	1880-1890	NN	denotes	population
T13440	1891-1894	CC	denotes	and
T13441	1895-1899	VBD	denotes	were
T13442	1900-1912	RB	denotes	additionally
T13443	1913-1918	VBN	denotes	shown
T13444	1919-1921	IN	denotes	as
T13445	1922-1925	NN	denotes	bar
T13446	1926-1932	NNS	denotes	graphs
T13447	1933-1934	-LRB-	denotes	(
T13448	1934-1935	FW	denotes	n
T13449	1936-1937	SYM	denotes	=
T13450	1938-1939	LS	denotes	2
T13451	1939-1940	-RRB-	denotes	)
T13452	1941-1942	-LRB-	denotes	(
T13453	1942-1943	NNP	denotes	B
T13454	1943-1944	-RRB-	denotes	)
T13455	1944-1945	.	denotes	.
T13456	1946-1947	-LRB-	denotes	(
T13457	1947-1948	NNP	denotes	C
T13458	1948-1949	-RRB-	denotes	)
T13459	1950-1952	NNP	denotes	WT
T13460	1953-1956	CC	denotes	and
T13461	1957-1961	VB	denotes	cpdm
T13462	1962-1966	NNP	denotes	BMDC
T13463	1967-1968	-LRB-	denotes	(
T13464	1968-1969	CD	denotes	5
T13465	1969-1970	CD	denotes	×
T13466	1970-1973	CD	denotes	105
T13467	1973-1974	-RRB-	denotes	)
T13468	1975-1980	NNS	denotes	cells
T13469	1981-1985	VBD	denotes	were
T13470	1986-1996	VBN	denotes	stimulated
T13471	1997-2001	IN	denotes	with
T13472	2002-2008	NN	denotes	medium
T13473	2008-2009	,	denotes	,
T13474	2010-2013	CD	denotes	100
T13475	2014-2019	JJ	denotes	ng/ml
T13476	2020-2023	NNP	denotes	LPS
T13477	2024-2026	CC	denotes	or
T13478	2027-2029	CD	denotes	25
T13479	2030-2032	NN	denotes	µg
T13480	2032-2033	NN	denotes	/
T13481	2033-2035	NN	denotes	ml
T13482	2036-2040	NN	denotes	poly
T13483	2041-2042	PRP	denotes	I
T13484	2042-2043	:	denotes	:
T13485	2043-2044	NNP	denotes	C
T13486	2045-2048	IN	denotes	for
T13487	2049-2051	CD	denotes	24
T13488	2052-2057	NNS	denotes	hours
T13489	2057-2058	.	denotes	.
T13490	2059-2062	DT	denotes	The
T13491	2063-2068	NNS	denotes	cells
T13492	2069-2073	VBD	denotes	were
T13493	2074-2081	VBN	denotes	labeled
T13494	2082-2086	IN	denotes	with
T13495	2087-2097	JJ	denotes	PE-labeled
T13496	2098-2107	JJ	denotes	anti-CD40
T13497	2107-2108	,	denotes	,
T13498	2109-2118	JJ	denotes	anti-CD80
T13499	2118-2119	,	denotes	,
T13500	2120-2123	CC	denotes	and
T13501	2124-2133	NNP	denotes	anti-CD86
T13502	2133-2134	,	denotes	,
T13503	2135-2138	CC	denotes	and
T13504	2139-2148	VBN	denotes	subjected
T13505	2149-2151	TO	denotes	to
T13506	2152-2156	VB	denotes	flow
T13507	2157-2166	JJ	denotes	cytometry
T13508	2167-2175	NN	denotes	analysis
T13509	2175-2176	.	denotes	.
T13510	2177-2180	DT	denotes	The
T13511	2181-2192	NNS	denotes	populations
T13512	2193-2198	VBN	denotes	shown
T13513	2199-2201	IN	denotes	in
T13514	2202-2212	NNS	denotes	histograms
T13515	2213-2217	VBD	denotes	were
T13516	2218-2223	VBN	denotes	gated
T13517	2224-2226	IN	denotes	on
T13518	2227-2232	JJ	denotes	CD11c
T13519	2232-2233	NN	denotes	+
T13520	2234-2239	NNS	denotes	cells
T13521	2239-2240	.	denotes	.
T13522	2241-2250	JJ	denotes	Unstained
T13523	2251-2256	NNS	denotes	cells
T13524	2257-2263	VBD	denotes	served
T13525	2264-2266	IN	denotes	as
T13526	2267-2275	JJ	denotes	negative
T13527	2276-2284	NNS	denotes	controls
T13528	2284-2285	.	denotes	.
T13529	2286-2293	NNS	denotes	Results
T13530	2294-2297	VBP	denotes	are
T13531	2298-2312	NN	denotes	representative
T13532	2313-2315	IN	denotes	of
T13533	2316-2319	CD	denotes	two
T13534	2320-2331	JJ	denotes	independent
T13535	2332-2343	NNS	denotes	experiments
T13536	2343-2344	.	denotes	.
R2330	T2885	T2885	ROOT	Phenotyping,Phenotyping
R2331	T2886	T2887	compound	splenic,DC
R2332	T2887	T2894	nmod	DC,mice
R2333	T2888	T2887	cc	and,DC
R2334	T2889	T2887	conj	BMDC,DC
R2335	T2890	T2889	prep	from,BMDC
R2336	T2891	T2890	pobj	WT,from
R2337	T2892	T2891	cc	and,WT
R2338	T2893	T2894	compound	cpdm,mice
R2339	T2894	T2885	dobj	mice,Phenotyping
R2340	T2895	T2896	nsubj	DC,are
R2341	T2896	T2885	ccomp	are,Phenotyping
R2342	T2897	T2896	acomp	heterogeneous,are
R2343	T2898	T2896	cc	and,are
R2344	T2899	T2901	aux	can,categorized
R2345	T2900	T2901	auxpass	be,categorized
R2346	T2901	T2896	conj	categorized,are
R2347	T2902	T2901	prep	into,categorized
R2348	T2903	T2904	amod	multiple,subtypes
R2349	T2904	T2902	pobj	subtypes,into
R2350	T2905	T2904	acl	based,subtypes
R2351	T2906	T2905	prep	on,based
R2352	T2907	T2908	compound	surface,markers
R2353	T2908	T2906	pobj	markers,on
R2354	T2909	T2911	nmod	[,]
R2355	T2910	T2911	nummod	13,]
R2356	T2911	T2908	appos	],markers
R2357	T2912	T2885	punct	.,Phenotyping
R2358	T2913	T2914	aux	To,determine
R2359	T2914	T2929	advcl	determine,examined
R2360	T2915	T2919	mark	if,affects
R2361	T2916	T2918	det	the,mutation
R2362	T2917	T2918	compound	Sharpin,mutation
R2363	T2918	T2919	nsubj	mutation,affects
R2364	T2919	T2914	ccomp	affects,determine
R2365	T2920	T2921	compound	DC,development
R2366	T2921	T2919	dobj	development,affects
R2367	T2922	T2921	prep	in,development
R2368	T2923	T2924	amod	lymphoid,tissues
R2369	T2924	T2922	pobj	tissues,in
R2370	T2925	T2929	punct	",",examined
R2371	T2926	T2927	compound	mouse,spleens
R2372	T2927	T2929	nsubjpass	spleens,examined
R2373	T2928	T2929	auxpass	were,examined
R2374	T2929	T2929	ROOT	examined,examined
R2375	T2930	T2929	prep	for,examined
R2376	T2931	T2932	det	the,distribution
R2377	T2932	T2930	pobj	distribution,for
R2378	T2933	T2932	prep	of,distribution
R2379	T2934	T2935	amod	conventional,DC
R2380	T2935	T2933	pobj	DC,of
R2381	T2936	T2937	punct	(,cDC
R2382	T2937	T2932	appos	cDC,distribution
R2383	T2938	T2937	punct	;,cDC
R2384	T2939	T2942	compound	CD11c,+
R2385	T2940	T2942	compound	+,+
R2386	T2941	T2942	compound	CD8α,+
R2387	T2942	T2966	dative	+,.
R2388	T2943	T2942	cc	and,+
R2389	T2944	T2942	conj	CD11c,+
R2390	T2945	T2947	compound	+,−
R2391	T2946	T2947	compound	CD8α,−
R2392	T2947	T2942	appos	−,+
R2393	T2948	T2947	punct	),−
R2394	T2949	T2951	nmod	[,]
R2395	T2950	T2951	nummod	13,]
R2396	T2951	T2942	conj	],+
R2397	T2952	T2951	cc	and,]
R2398	T2953	T2954	amod	plasmacytoid,DC
R2399	T2954	T2951	conj	DC,]
R2400	T2955	T2956	punct	(,pDC
R2401	T2956	T2951	conj	pDC,]
R2402	T2957	T2956	punct	;,pDC
R2403	T2958	T2961	compound	CD11c,+
R2404	T2959	T2961	compound	−,+
R2405	T2960	T2961	compound	PDCA-1,+
R2406	T2961	T2966	dative	+,.
R2407	T2962	T2963	punct	),[
R2408	T2963	T2965	nmod	[,]
R2409	T2964	T2965	nummod	14,]
R2410	T2965	T2961	dobj	],+
R2411	T2966	T2929	punct	.,examined
R2412	T2967	T2968	det	The,percentages
R2413	T2968	T2976	nsubjpass	percentages,reduced
R2414	T2969	T2968	prep	for,percentages
R2415	T2970	T2971	compound	splenic,cDC
R2416	T2971	T2969	pobj	cDC,for
R2417	T2972	T2971	cc	and,cDC
R2418	T2973	T2971	conj	pDC,cDC
R2419	T2974	T2976	auxpass	were,reduced
R2420	T2975	T2976	dep	both,reduced
R2421	T2976	T2976	ROOT	reduced,reduced
R2422	T2977	T2976	prep	in,reduced
R2423	T2978	T2979	compound	cpdm,mice
R2424	T2979	T2977	pobj	mice,in
R2425	T2980	T2981	advmod	when,compared
R2426	T2981	T2976	advcl	compared,reduced
R2427	T2982	T2981	prep	with,compared
R2428	T2983	T2984	compound	WT,controls
R2429	T2984	T2982	pobj	controls,with
R2430	T2985	T2987	punct	(,2A
R2431	T2986	T2987	compound	Fig.,2A
R2432	T2987	T2984	appos	2A,controls
R2433	T2988	T2984	punct	),controls
R2434	T2989	T2976	punct	.,reduced
R2435	T2990	T3010	advmod	However,affected
R2436	T2991	T3010	punct	",",affected
R2437	T2992	T2993	advmod	when,gated
R2438	T2993	T3010	advcl	gated,affected
R2439	T2994	T2993	prep	on,gated
R2440	T2995	T2997	amod	CD11c,cDC
R2441	T2996	T2997	compound	+,cDC
R2442	T2997	T2994	pobj	cDC,on
R2443	T2998	T2997	punct	",",cDC
R2444	T2999	T3000	det	the,percentages
R2445	T3000	T3010	nsubjpass	percentages,affected
R2446	T3001	T3000	prep	of,percentages
R2447	T3002	T3003	amod	CD8α,+
R2448	T3003	T3001	pobj	+,of
R2449	T3004	T3003	cc	and,+
R2450	T3005	T3007	amod	CD8α,cells
R2451	T3006	T3007	compound	−,cells
R2452	T3007	T3003	conj	cells,+
R2453	T3008	T3010	auxpass	were,affected
R2454	T3009	T3010	neg	not,affected
R2455	T3010	T3010	ROOT	affected,affected
R2456	T3011	T3010	agent	by,affected
R2457	T3012	T3013	compound	SHARPIN,deficiency
R2458	T3013	T3011	pobj	deficiency,by
R2459	T3014	T3013	punct	(,deficiency
R2460	T3015	T3016	compound	Fig.,2A
R2461	T3016	T3013	appos	2A,deficiency
R2462	T3017	T3013	punct	),deficiency
R2463	T3018	T3010	punct	.,affected
R2464	T3019	T3025	mark	Since,is
R2465	T3020	T3021	det	the,spleen
R2466	T3021	T3025	nsubj	spleen,is
R2467	T3022	T3021	prep	of,spleen
R2468	T3023	T3024	compound	cpdm,mice
R2469	T3024	T3022	pobj	mice,of
R2470	T3025	T3025	ROOT	is,is
R2471	T3026	T3027	advmod	markedly,enlarged
R2472	T3027	T3025	acomp	enlarged,is
R2473	T3028	T3025	cc	and,is
R2474	T3029	T3025	conj	contains,is
R2475	T3030	T3034	nummod	three,cells
R2476	T3031	T3030	quantmod	times,three
R2477	T3032	T3033	advmod	as,many
R2478	T3033	T3034	amod	many,cells
R2479	T3034	T3029	dobj	cells,contains
R2480	T3035	T3034	punct	(,cells
R2481	T3036	T3037	compound	Fig.,1C
R2482	T3037	T3034	appos	1C,cells
R2483	T3038	T3034	punct	),cells
R2484	T3039	T3034	punct	",",cells
R2485	T3040	T3042	det	the,percentages
R2486	T3041	T3042	amod	different,percentages
R2487	T3042	T3034	appos	percentages,cells
R2488	T3043	T3042	prep	of,percentages
R2489	T3044	T3045	compound	splenic,cDC
R2490	T3045	T3043	pobj	cDC,of
R2491	T3046	T3045	cc	and,cDC
R2492	T3047	T3045	conj	pDC,cDC
R2493	T3048	T3042	prep	between,percentages
R2494	T3049	T3048	pobj	WT,between
R2495	T3050	T3049	cc	and,WT
R2496	T3051	T3052	amod	mutant,mice
R2497	T3052	T3049	conj	mice,WT
R2498	T3053	T3029	conj	reflect,contains
R2499	T3054	T3056	det	the,number
R2500	T3055	T3056	amod	increased,number
R2501	T3056	T3053	dobj	number,reflect
R2502	T3057	T3056	prep	of,number
R2503	T3058	T3060	amod	total,cells
R2504	T3059	T3060	compound	spleen,cells
R2505	T3060	T3057	pobj	cells,of
R2506	T3061	T3062	advmod	rather,than
R2507	T3062	T3056	cc	than,number
R2508	T3063	T3064	det	a,reduction
R2509	T3064	T3056	conj	reduction,number
R2510	T3065	T3064	prep	in,reduction
R2511	T3066	T3065	pobj	cDC,in
R2512	T3067	T3066	cc	and,cDC
R2513	T3068	T3066	conj	pDC,cDC
R2514	T3069	T3064	conj	numbers,reduction
R2515	T3070	T3025	punct	.,is
R2516	T3071	T3072	det	These,data
R2517	T3072	T3073	nsubj	data,indicate
R2518	T3073	T3073	ROOT	indicate,indicate
R2519	T3074	T3080	mark	that,affect
R2520	T3075	T3077	det	the,mutation
R2521	T3076	T3077	compound	Sharpin,mutation
R2522	T3077	T3080	nsubj	mutation,affect
R2523	T3078	T3080	aux	does,affect
R2524	T3079	T3080	neg	not,affect
R2525	T3080	T3073	ccomp	affect,indicate
R2526	T3081	T3082	det	the,distribution
R2527	T3082	T3080	dobj	distribution,affect
R2528	T3083	T3082	prep	of,distribution
R2529	T3084	T3087	det	the,subsets
R2530	T3085	T3087	amod	examined,subsets
R2531	T3086	T3087	compound	DC,subsets
R2532	T3087	T3083	pobj	subsets,of
R2533	T3088	T3087	prep	in,subsets
R2534	T3089	T3090	det	the,spleen
R2535	T3090	T3088	pobj	spleen,in
R2536	T3091	T3073	punct	.,indicate
R2537	T3092	T3098	nsubj	BMDC,resemble
R2538	T3093	T3092	prep	from,BMDC
R2539	T3094	T3093	prep	in,from
R2540	T3095	T3096	compound	vitro,cultures
R2541	T3096	T3094	pobj	cultures,in
R2542	T3097	T3098	advmod	functionally,resemble
R2543	T3098	T3098	ROOT	resemble,resemble
R2544	T3099	T3101	compound	non-lymphoid,DC
R2545	T3100	T3101	compound	tissue,DC
R2546	T3101	T3098	dobj	DC,resemble
R2547	T3102	T3101	cc	and,DC
R2548	T3103	T3108	amod	monocyte-derived,]
R2549	T3104	T3108	nmod	inflammatory,]
R2550	T3105	T3106	compound	DC,[
R2551	T3106	T3104	appos	[,inflammatory
R2552	T3107	T3108	nummod	15,]
R2553	T3108	T3101	conj	],DC
R2554	T3109	T3108	punct	",",]
R2555	T3110	T3112	nmod	[,]
R2556	T3111	T3112	nummod	16,]
R2557	T3112	T3108	conj	],]
R2558	T3113	T3098	punct	.,resemble
R2559	T3114	T3115	det	The,yields
R2560	T3115	T3123	nsubj	yields,were
R2561	T3116	T3115	prep	of,yields
R2562	T3117	T3116	pobj	BMDC,of
R2563	T3118	T3117	prep	from,BMDC
R2564	T3119	T3118	pobj	WT,from
R2565	T3120	T3117	cc	and,BMDC
R2566	T3121	T3122	compound	cpdm,mice
R2567	T3122	T3123	nsubj	mice,were
R2568	T3123	T3123	ROOT	were,were
R2569	T3124	T3123	acomp	similar,were
R2570	T3125	T3123	punct	.,were
R2571	T3126	T3127	nsubj	BMDC,were
R2572	T3127	T3127	ROOT	were,were
R2573	T3128	T3129	amod	CD11c,+
R2574	T3129	T3127	attr	+,were
R2575	T3130	T3129	cc	and,+
R2576	T3131	T3133	compound	MHC,+
R2577	T3132	T3133	compound	II,+
R2578	T3133	T3129	conj	+,+
R2579	T3134	T3129	prep	with,+
R2580	T3135	T3136	amod	low,expression
R2581	T3136	T3134	pobj	expression,with
R2582	T3137	T3136	prep	of,expression
R2583	T3138	T3139	amod	co-stimulatory,molecules
R2584	T3139	T3137	pobj	molecules,of
R2585	T3140	T3136	appos	CD40,expression
R2586	T3141	T3140	punct	",",CD40
R2587	T3142	T3140	conj	CD80,CD40
R2588	T3143	T3142	punct	",",CD80
R2589	T3144	T3142	cc	and,CD80
R2590	T3145	T3142	conj	CD86,CD80
R2591	T3146	T3127	punct	.,were
R2592	T3147	T3150	det	The,poly
R2593	T3148	T3150	nummod	TLR3,poly
R2594	T3149	T3150	compound	ligand,poly
R2595	T3150	T3160	nsubj	poly,activate
R2596	T3151	T3153	nsubj	I,C
R2597	T3152	T3153	punct	:,C
R2598	T3153	T3150	appos	C,poly
R2599	T3154	T3153	cc	and,C
R2600	T3155	T3158	det	the,LPS
R2601	T3156	T3158	nummod	TLR4,LPS
R2602	T3157	T3158	compound	ligand,LPS
R2603	T3158	T3153	conj	LPS,C
R2604	T3159	T3160	dep	each,activate
R2605	T3160	T3160	ROOT	activate,activate
R2606	T3161	T3160	xcomp	overlapping,activate
R2607	T3162	T3160	cc	but,activate
R2608	T3163	T3165	amod	different,pathways
R2609	T3164	T3165	compound	signaling,pathways
R2610	T3165	T3160	dobj	pathways,activate
R2611	T3166	T3160	cc	and,activate
R2612	T3167	T3168	auxpass	were,used
R2613	T3168	T3160	conj	used,activate
R2614	T3169	T3170	aux	to,induce
R2615	T3170	T3168	xcomp	induce,used
R2616	T3171	T3177	nmod	DC,[
R2617	T3172	T3175	nmod	maturation,]
R2618	T3173	T3175	nmod	[,]
R2619	T3174	T3175	nummod	17,]
R2620	T3175	T3177	nmod	],[
R2621	T3176	T3177	punct	",",[
R2622	T3177	T3179	nmod	[,]
R2623	T3178	T3179	nummod	18,]
R2624	T3179	T3170	dobj	],induce
R2625	T3180	T3160	punct	.,activate
R2626	T3181	T3189	nsubj	Incubation,resulted
R2627	T3182	T3181	prep	with,Incubation
R2628	T3183	T3185	det	the,agonists
R2629	T3184	T3185	compound	TLR,agonists
R2630	T3185	T3182	pobj	agonists,with
R2631	T3186	T3181	prep	for,Incubation
R2632	T3187	T3188	nummod	24,hours
R2633	T3188	T3186	pobj	hours,for
R2634	T3189	T3206	ccomp	resulted,was
R2650	T3205	T3206	expl	there,was
R2651	T3206	T3206	ROOT	was,was
R2652	T3207	T3208	det	no,difference
R2653	T3208	T3206	attr	difference,was
R2654	T3209	T3208	prep	in,difference
R2655	T3210	T3212	det	the,levels
R2656	T3211	T3212	compound	expression,levels
R2657	T3212	T3209	pobj	levels,in
R2658	T3213	T3212	prep	of,levels
R2659	T3214	T3215	det	these,markers
R2660	T3215	T3213	pobj	markers,of
R2661	T3216	T3215	prep	between,markers
R2662	T3217	T3216	pobj	WT,between
R2663	T3218	T3217	cc	and,WT
R2664	T3219	T3220	compound	cpdm,BMDC
R2665	T3220	T3217	conj	BMDC,WT
R2666	T3221	T3223	punct	(,2B
R2667	T3222	T3223	compound	Fig.,2B
R2668	T3223	T3220	appos	2B,BMDC
R2669	T3224	T3223	punct	),2B
R2670	T3225	T3206	punct	.,was
R2671	T3226	T3232	advmod	Thus,influence
R2672	T3227	T3232	punct	",",influence
R2673	T3228	T3229	compound	SHARPIN,deficiency
R2674	T3229	T3232	nsubj	deficiency,influence
R2675	T3230	T3232	aux	did,influence
R2676	T3231	T3232	neg	not,influence
R2677	T3232	T3232	ROOT	influence,influence
R2678	T3233	T3234	det	the,expression
R2679	T3234	T3232	dobj	expression,influence
R2680	T3235	T3234	prep	of,expression
R2681	T3236	T3237	amod	co-stimulatory,molecules
R2682	T3237	T3235	pobj	molecules,of
R2683	T3238	T3232	prep	by,influence
R2684	T3239	T3238	pobj	BMDC,by
R2685	T3240	T3232	punct	.,influence
R11007	T13275	T13275	ROOT	Effect,Effect
R11008	T13276	T13275	prep	of,Effect
R11009	T13277	T13278	compound	Sharpin,mutation
R11010	T13278	T13276	pobj	mutation,of
R11011	T13279	T13278	prep	on,mutation
R11012	T13280	T13281	compound	DC,subpopulations
R11013	T13281	T13279	pobj	subpopulations,on
R11014	T13282	T13281	cc	and,subpopulations
R11015	T13283	T13281	conj	maturation,subpopulations
R11016	T13284	T13275	punct	.,Effect
R11017	T13285	T13288	punct	(,Spleens
R11018	T13286	T13288	nmod	A,Spleens
R11019	T13287	T13288	punct	),Spleens
R11020	T13288	T13293	nmod	Spleens,mice
R11021	T13289	T13288	prep	from,Spleens
R11022	T13290	T13289	pobj	WT,from
R11023	T13291	T13290	cc	and,WT
R11024	T13292	T13293	compound	cpdm,mice
R11025	T13293	T13293	ROOT	mice,mice
R11026	T13294	T13293	aux	were,mice
R11027	T13295	T13294	acomp	isolated,were
R11028	T13296	T13295	cc	and,isolated
R11029	T13297	T13295	conj	subject,isolated
R11030	T13298	T13297	prep	to,subject
R11031	T13299	T13298	pobj	collagenase,to
R11032	T13300	T13299	cc	and,collagenase
R11033	T13301	T13299	conj	DNase,collagenase
R11034	T13302	T13301	dobj	digestion,DNase
R11035	T13303	T13294	punct	.,were
R11036	T13304	T13307	det	The,homogenates
R11037	T13305	T13307	amod	obtained,homogenates
R11038	T13306	T13307	amod	splenic,homogenates
R11039	T13307	T13309	nsubjpass	homogenates,centrifuged
R11040	T13308	T13309	auxpass	were,centrifuged
R11041	T13309	T13309	ROOT	centrifuged,centrifuged
R11042	T13310	T13309	prep	over,centrifuged
R11043	T13311	T13313	det	a,gradient
R11044	T13312	T13313	compound	Percoll,gradient
R11045	T13313	T13310	pobj	gradient,over
R11046	T13314	T13313	punct	(,gradient
R11047	T13315	T13316	nummod	35,%
R11048	T13316	T13313	appos	%,gradient
R11049	T13317	T13316	cc	and,%
R11050	T13318	T13319	nummod	55,%
R11051	T13319	T13320	compound	%,density
R11052	T13320	T13316	conj	density,%
R11053	T13321	T13313	punct	),gradient
R11054	T13322	T13309	prep	for,centrifuged
R11055	T13323	T13324	nummod	15,minutes
R11056	T13324	T13322	pobj	minutes,for
R11057	T13325	T13309	punct	.,centrifuged
R11058	T13326	T13327	det	The,bands
R11059	T13327	T13341	nsubjpass	bands,pooled
R11060	T13328	T13327	prep	at,bands
R11061	T13329	T13333	det	the,medium
R11062	T13330	T13331	nummod	35,%
R11063	T13331	T13333	compound	%,medium
R11064	T13332	T13333	punct	-,medium
R11065	T13333	T13328	pobj	medium,at
R11066	T13334	T13333	cc	and,medium
R11067	T13335	T13336	det	the,35
R11068	T13336	T13333	conj	35,medium
R11069	T13337	T13338	nummod	55,%
R11070	T13338	T13339	compound	%,interface
R11071	T13339	T13341	nsubjpass	interface,pooled
R11072	T13340	T13341	auxpass	were,pooled
R11073	T13341	T13341	ROOT	pooled,pooled
R11074	T13342	T13341	punct	",",pooled
R11075	T13343	T13341	conj	washed,pooled
R11076	T13344	T13343	cc	and,washed
R11077	T13345	T13343	conj	stained,washed
R11078	T13346	T13345	prep	with,stained
R11079	T13347	T13348	det	a,combination
R11080	T13348	T13346	pobj	combination,with
R11081	T13349	T13348	prep	of,combination
R11082	T13350	T13351	amod	various,antibodies
R11083	T13351	T13349	pobj	antibodies,of
R11084	T13352	T13353	aux	to,stain
R11085	T13353	T13345	advcl	stain,stained
R11086	T13354	T13356	amod	different,subsets
R11087	T13355	T13356	compound	DC,subsets
R11088	T13356	T13353	dobj	subsets,stain
R11089	T13357	T13356	punct	",",subsets
R11090	T13358	T13360	amod	conventional,+
R11091	T13359	T13360	amod	CD11c,+
R11092	T13360	T13362	compound	+,+
R11093	T13361	T13362	compound	CD8α,+
R11094	T13362	T13353	npadvmod	+,stain
R11095	T13363	T13362	punct	",",+
R11096	T13364	T13367	compound	CD11c,−
R11097	T13365	T13367	compound	+,−
R11098	T13366	T13367	compound	CD8α,−
R11099	T13367	T13362	conj	−,+
R11100	T13368	T13367	cc	and,−
R11101	T13369	T13370	amod	plasmacytoid,DC
R11102	T13370	T13367	conj	DC,−
R11103	T13371	T13375	punct	(,+
R11104	T13372	T13375	compound	CD11c,+
R11105	T13373	T13375	compound	−,+
R11106	T13374	T13375	compound	PDCA-1,+
R11107	T13375	T13367	appos	+,−
R11108	T13376	T13367	punct	),−
R11109	T13377	T13341	punct	.,pooled
R11110	T13378	T13380	det	The,panels
R11111	T13379	T13380	amod	top,panels
R11112	T13380	T13382	nsubjpass	panels,gated
R11113	T13381	T13382	auxpass	were,gated
R11114	T13382	T13382	ROOT	gated,gated
R11115	T13383	T13382	prep	on,gated
R11116	T13384	T13385	compound	FSChiSSClo,cells
R11117	T13385	T13383	pobj	cells,on
R11118	T13386	T13387	aux	to,show
R11119	T13387	T13382	advcl	show,gated
R11120	T13388	T13389	amod	separate,populations
R11121	T13389	T13387	dobj	populations,show
R11122	T13390	T13389	prep	of,populations
R11123	T13391	T13394	amod	CD11c,−
R11124	T13392	T13394	nmod	+,−
R11125	T13393	T13394	compound	PDCA-1,−
R11126	T13394	T13400	nmod	−,cells
R11127	T13395	T13394	cc	and,−
R11128	T13396	T13400	amod	CD11c,cells
R11129	T13397	T13400	compound	−,cells
R11130	T13398	T13400	compound	PDCA-1,cells
R11131	T13399	T13400	compound	+,cells
R11132	T13400	T13390	pobj	cells,of
R11133	T13401	T13382	punct	.,gated
R11134	T13402	T13403	amod	Further,gating
R11135	T13403	T13411	nsubj	gating,gave
R11136	T13404	T13403	prep	on,gating
R11137	T13405	T13410	det	the,subpopulation
R11138	T13406	T13410	amod	CD11c,subpopulation
R11139	T13407	T13410	nmod	+,subpopulation
R11140	T13408	T13410	nmod	PDCA-1,subpopulation
R11141	T13409	T13410	compound	−,subpopulation
R11142	T13410	T13404	pobj	subpopulation,on
R11143	T13411	T13411	ROOT	gave,gave
R11144	T13412	T13414	det	the,panel
R11145	T13413	T13414	amod	bottom,panel
R11146	T13414	T13411	dobj	panel,gave
R11147	T13415	T13416	nsubj	that,showed
R11148	T13416	T13414	relcl	showed,panel
R11149	T13417	T13419	nummod	two,pools
R11150	T13418	T13419	amod	distinct,pools
R11151	T13419	T13416	dobj	pools,showed
R11152	T13420	T13419	prep	of,pools
R11153	T13421	T13424	amod	CD11c,+
R11154	T13422	T13424	compound	+,+
R11155	T13423	T13424	compound	CD8α,+
R11156	T13424	T13420	pobj	+,of
R11157	T13425	T13424	cc	and,+
R11158	T13426	T13424	conj	CD11c,+
R11159	T13427	T13416	ccomp	+,showed
R11160	T13428	T13430	amod	CD8α,cells
R11161	T13429	T13430	compound	−,cells
R11162	T13430	T13427	dobj	cells,+
R11163	T13431	T13411	punct	.,gave
R11164	T13432	T13434	nsubjpass	Percentages,calculated
R11165	T13433	T13434	auxpass	were,calculated
R11166	T13434	T13434	ROOT	calculated,calculated
R11167	T13435	T13434	prep	based,calculated
R11168	T13436	T13435	prep	on,based
R11169	T13437	T13439	det	the,population
R11170	T13438	T13439	amod	parental,population
R11171	T13439	T13436	pobj	population,on
R11172	T13440	T13434	cc	and,calculated
R11173	T13441	T13443	auxpass	were,shown
R11174	T13442	T13443	advmod	additionally,shown
R11175	T13443	T13434	conj	shown,calculated
R11176	T13444	T13443	prep	as,shown
R11177	T13445	T13446	compound	bar,graphs
R11178	T13446	T13444	pobj	graphs,as
R11179	T13447	T13446	punct	(,graphs
R11180	T13448	T13446	appos	n,graphs
R11181	T13449	T13450	punct	=,2
R11182	T13450	T13453	meta	2,B
R11183	T13451	T13450	punct	),2
R11184	T13452	T13453	punct	(,B
R11185	T13453	T13446	appos	B,graphs
R11186	T13454	T13453	punct	),B
R11187	T13455	T13443	punct	.,shown
R11188	T13456	T13459	punct	(,WT
R11189	T13457	T13459	compound	C,WT
R11190	T13458	T13457	punct	),C
R11191	T13459	T13468	nmod	WT,cells
R11192	T13460	T13459	cc	and,WT
R11193	T13461	T13462	compound	cpdm,BMDC
R11194	T13462	T13459	conj	BMDC,WT
R11195	T13463	T13464	punct	(,5
R11196	T13464	T13468	nummod	5,cells
R11197	T13465	T13466	nummod	×,105
R11198	T13466	T13464	appos	105,5
R11199	T13467	T13464	punct	),5
R11200	T13468	T13470	nsubjpass	cells,stimulated
R11201	T13469	T13470	auxpass	were,stimulated
R11202	T13470	T13470	ROOT	stimulated,stimulated
R11203	T13471	T13470	prep	with,stimulated
R11204	T13472	T13471	pobj	medium,with
R11205	T13473	T13472	punct	",",medium
R11206	T13474	T13476	nummod	100,LPS
R11207	T13475	T13476	compound	ng/ml,LPS
R11208	T13476	T13472	conj	LPS,medium
R11209	T13477	T13476	cc	or,LPS
R11210	T13478	T13482	nummod	25,poly
R11211	T13479	T13482	nmod	µg,poly
R11212	T13480	T13482	nmod	/,poly
R11213	T13481	T13482	compound	ml,poly
R11214	T13482	T13476	conj	poly,LPS
R11215	T13483	T13485	nsubj	I,C
R11216	T13484	T13485	punct	:,C
R11217	T13485	T13470	npadvmod	C,stimulated
R11218	T13486	T13485	prep	for,C
R11219	T13487	T13488	nummod	24,hours
R11220	T13488	T13486	pobj	hours,for
R11221	T13489	T13470	punct	.,stimulated
R11222	T13490	T13491	det	The,cells
R11223	T13491	T13493	nsubjpass	cells,labeled
R11224	T13492	T13493	auxpass	were,labeled
R11225	T13493	T13493	ROOT	labeled,labeled
R11226	T13494	T13493	prep	with,labeled
R11227	T13495	T13504	amod	PE-labeled,subjected
R11228	T13496	T13504	amod	anti-CD40,subjected
R11229	T13497	T13496	punct	",",anti-CD40
R11230	T13498	T13496	conj	anti-CD80,anti-CD40
R11231	T13499	T13498	punct	",",anti-CD80
R11232	T13500	T13498	cc	and,anti-CD80
R11233	T13501	T13498	conj	anti-CD86,anti-CD80
R11234	T13502	T13501	punct	",",anti-CD86
R11235	T13503	T13498	cc	and,anti-CD80
R11236	T13504	T13493	conj	subjected,labeled
R11237	T13505	T13506	aux	to,flow
R11238	T13506	T13504	xcomp	flow,subjected
R11239	T13507	T13508	amod	cytometry,analysis
R11240	T13508	T13506	dobj	analysis,flow
R11241	T13509	T13493	punct	.,labeled
R11242	T13510	T13511	det	The,populations
R11243	T13511	T13516	nsubjpass	populations,gated
R11244	T13512	T13511	acl	shown,populations
R11245	T13513	T13512	prep	in,shown
R11246	T13514	T13513	pobj	histograms,in
R11247	T13515	T13516	auxpass	were,gated
R11248	T13516	T13516	ROOT	gated,gated
R11249	T13517	T13516	prep	on,gated
R11250	T13518	T13520	amod	CD11c,cells
R11251	T13519	T13520	compound	+,cells
R11252	T13520	T13517	pobj	cells,on
R11253	T13521	T13516	punct	.,gated
R11254	T13522	T13523	amod	Unstained,cells
R11255	T13523	T13524	nsubj	cells,served
R11256	T13524	T13524	ROOT	served,served
R11257	T13525	T13524	prep	as,served
R11258	T13526	T13527	amod	negative,controls
R11259	T13527	T13525	pobj	controls,as
R11260	T13528	T13524	punct	.,served
R11261	T13529	T13530	nsubj	Results,are
R11262	T13530	T13530	ROOT	are,are
R11263	T13531	T13530	attr	representative,are
R11264	T13532	T13531	prep	of,representative
R11265	T13533	T13535	nummod	two,experiments
R11266	T13534	T13535	amod	independent,experiments
R11267	T13535	T13532	pobj	experiments,of
R11268	T13536	T13530	punct	.,are
R2635	T3190	T3189	prep	in,resulted
R2636	T3191	T3192	amod	increased,expression
R2637	T3192	T3190	pobj	expression,in
R2638	T3193	T3192	prep	of,expression
R2639	T3194	T3193	pobj	CD40,of
R2640	T3195	T3194	punct	",",CD40
R2641	T3196	T3194	conj	CD80,CD40
R2642	T3197	T3196	punct	",",CD80
R2643	T3198	T3196	cc	and,CD80
R2644	T3199	T3196	conj	CD86,CD80
R2645	T3200	T3199	prep	on,CD86
R2646	T3201	T3200	pobj	BMDC,on
R2647	T3202	T3206	punct	;,was
R2648	T3203	T3206	advmod	however,was
R2649	T3204	T3206	punct	",",was

UBERON-AE

Id	Subject	Object	Predicate	Lexical cue
T2869	638-644	http://purl.obolibrary.org/obo/UBERON_0002106	denotes	spleen
T2870	843-849	http://purl.obolibrary.org/obo/UBERON_0002106	denotes	spleen
T2871	1017-1023	http://purl.obolibrary.org/obo/UBERON_0002106	denotes	spleen
T13262	1137-1144	http://purl.obolibrary.org/obo/UBERON_0002106	denotes	Spleens
T2864	215-231	http://purl.obolibrary.org/obo/UBERON_0001744	denotes	lymphoid tissues
T2865	2401-2416	http://purl.obolibrary.org/obo/UBERON_0001744	denotes	lymphoid tissue
T2866	224-231	http://purl.obolibrary.org/obo/UBERON_0000479	denotes	tissues
T2867	2410-2416	http://purl.obolibrary.org/obo/UBERON_0000479	denotes	tissue
T2868	239-246	http://purl.obolibrary.org/obo/UBERON_0002106	denotes	spleens

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T3645	200-211	http://purl.obolibrary.org/obo/GO_0032502	denotes	development
T3646	2712-2721	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T3647	2712-2730	http://purl.obolibrary.org/obo/GO_0007165	denotes	signaling pathways
T13777	1218-1227	http://purl.obolibrary.org/obo/GO_0007586	denotes	digestion

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T3648	2632-2638	http://purl.obolibrary.org/obo/GO_0005488	denotes	ligand
T3649	2661-2667	http://purl.obolibrary.org/obo/GO_0005488	denotes	ligand
T13778	1456-1466	http://purl.obolibrary.org/obo/GO_0003823	denotes	antibodies

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T13779	1456-1466	http://purl.obolibrary.org/obo/GO_0019815	denotes	antibodies
T13780	1456-1466	http://purl.obolibrary.org/obo/GO_0042571	denotes	antibodies
T13781	1612-1617	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T13782	1682-1687	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T13783	1823-1828	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T13784	1975-1980	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T13785	2063-2068	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T13786	2234-2239	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T13787	2251-2256	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T3650	571-576	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T3651	712-717	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T3652	850-855	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells

sentences

Id	Subject	Object	Predicate	Lexical cue
T2877	628-903	Sentence	denotes	Since the spleen of cpdm mice is markedly enlarged and contains three times as many cells (Fig. 1C), the different percentages of splenic cDC and pDC between WT and mutant mice reflect the increased number of total spleen cells rather than a reduction in cDC and pDC numbers.
T2878	904-1024	Sentence	denotes	These data indicate that the Sharpin mutation does not affect the distribution of the examined DC subsets in the spleen.
T2879	2347-2468	Sentence	denotes	BMDC from in vitro cultures functionally resemble non-lymphoid tissue DC and monocyte-derived inflammatory DC [15], [16].
T2880	2469-2523	Sentence	denotes	The yields of BMDC from WT and cpdm mice were similar.
T2881	2524-2622	Sentence	denotes	BMDC were CD11c+ and MHC II+ with low expression of co-stimulatory molecules CD40, CD80, and CD86.
T2882	2623-2780	Sentence	denotes	The TLR3 ligand poly I:C and the TLR4 ligand LPS each activate overlapping but different signaling pathways and were used to induce DC maturation [17], [18].
T2883	2781-3003	Sentence	denotes	Incubation with the TLR agonists for 24 hours resulted in increased expression of CD40, CD80, and CD86 on BMDC; however, there was no difference in the expression levels of these markers between WT and cpdm BMDC (Fig. 2B).
T2884	3004-3098	Sentence	denotes	Thus, SHARPIN deficiency did not influence the expression of co-stimulatory molecules by BMDC.
T13265	1069-1132	Sentence	denotes	Effect of Sharpin mutation on DC subpopulations and maturation.
T13266	1133-1228	Sentence	denotes	(A) Spleens from WT and cpdm mice were isolated and subject to collagenase and DNase digestion.
T13267	1229-1340	Sentence	denotes	The obtained splenic homogenates were centrifuged over a Percoll gradient (35% and 55% density) for 15 minutes.
T13268	1341-1688	Sentence	denotes	The bands at the 35%-medium and the 35–55% interface were pooled, washed and stained with a combination of various antibodies to stain different DC subsets, conventional CD11c+CD8α+, CD11c+CD8α− and plasmacytoid DC (CD11c−PDCA-1+).The top panels were gated on FSChiSSClo cells to show separate populations of CD11c+PDCA-1− and CD11c−PDCA-1+ cells.
T13269	1689-1829	Sentence	denotes	Further gating on the CD11c+PDCA-1− subpopulation gave the bottom panel that showed two distinct pools of CD11c+CD8α+ and CD11c+CD8α− cells.
T13270	1830-2058	Sentence	denotes	Percentages were calculated based on the parental population and were additionally shown as bar graphs (n = 2) (B). (C) WT and cpdm BMDC (5×105) cells were stimulated with medium, 100 ng/ml LPS or 25 µg/ml poly I:C for 24 hours.
T13271	2059-2176	Sentence	denotes	The cells were labeled with PE-labeled anti-CD40, anti-CD80, and anti-CD86, and subjected to flow cytometry analysis.
T13272	2177-2240	Sentence	denotes	The populations shown in histograms were gated on CD11c+ cells.
T13273	2241-2285	Sentence	denotes	Unstained cells served as negative controls.
T13274	2286-2344	Sentence	denotes	Results are representative of two independent experiments.
T2872	0-53	Sentence	denotes	Phenotyping splenic DC and BMDC from WT and cpdm mice
T2873	54-151	Sentence	denotes	DC are heterogeneous and can be categorized into multiple subtypes based on surface markers [13].
T2874	152-387	Sentence	denotes	To determine if the Sharpin mutation affects DC development in lymphoid tissues, mouse spleens were examined for the distribution of conventional DC (cDC; CD11c+CD8α+ and CD11c+CD8α−) [13] and plasmacytoid DC (pDC; CD11c−PDCA-1+) [14].
T2875	388-500	Sentence	denotes	The percentages for splenic cDC and pDC were both reduced in cpdm mice when compared with WT controls (Fig. 2A).
T2876	501-627	Sentence	denotes	However, when gated on CD11c+ cDC, the percentages of CD8α+ and CD8α− cells were not affected by SHARPIN deficiency (Fig. 2A).
T49	0-53	Sentence	denotes	Phenotyping splenic DC and BMDC from WT and cpdm mice
T50	54-151	Sentence	denotes	DC are heterogeneous and can be categorized into multiple subtypes based on surface markers [13].
T51	152-387	Sentence	denotes	To determine if the Sharpin mutation affects DC development in lymphoid tissues, mouse spleens were examined for the distribution of conventional DC (cDC; CD11c+CD8α+ and CD11c+CD8α−) [13] and plasmacytoid DC (pDC; CD11c−PDCA-1+) [14].
T52	388-500	Sentence	denotes	The percentages for splenic cDC and pDC were both reduced in cpdm mice when compared with WT controls (Fig. 2A).
T53	501-627	Sentence	denotes	However, when gated on CD11c+ cDC, the percentages of CD8α+ and CD8α− cells were not affected by SHARPIN deficiency (Fig. 2A).
T54	628-903	Sentence	denotes	Since the spleen of cpdm mice is markedly enlarged and contains three times as many cells (Fig. 1C), the different percentages of splenic cDC and pDC between WT and mutant mice reflect the increased number of total spleen cells rather than a reduction in cDC and pDC numbers.
T55	904-1024	Sentence	denotes	These data indicate that the Sharpin mutation does not affect the distribution of the examined DC subsets in the spleen.
T56	1025-1132	Sentence	denotes	10.1371/journal.pone.0031809.g002 Figure 2 Effect of Sharpin mutation on DC subpopulations and maturation.
T57	1133-1228	Sentence	denotes	(A) Spleens from WT and cpdm mice were isolated and subject to collagenase and DNase digestion.
T58	1229-1340	Sentence	denotes	The obtained splenic homogenates were centrifuged over a Percoll gradient (35% and 55% density) for 15 minutes.
T59	1341-1688	Sentence	denotes	The bands at the 35%-medium and the 35–55% interface were pooled, washed and stained with a combination of various antibodies to stain different DC subsets, conventional CD11c+CD8α+, CD11c+CD8α− and plasmacytoid DC (CD11c−PDCA-1+).The top panels were gated on FSChiSSClo cells to show separate populations of CD11c+PDCA-1− and CD11c−PDCA-1+ cells.
T60	1689-1829	Sentence	denotes	Further gating on the CD11c+PDCA-1− subpopulation gave the bottom panel that showed two distinct pools of CD11c+CD8α+ and CD11c+CD8α− cells.
T61	1830-2058	Sentence	denotes	Percentages were calculated based on the parental population and were additionally shown as bar graphs (n = 2) (B). (C) WT and cpdm BMDC (5×105) cells were stimulated with medium, 100 ng/ml LPS or 25 µg/ml poly I:C for 24 hours.
T62	2059-2176	Sentence	denotes	The cells were labeled with PE-labeled anti-CD40, anti-CD80, and anti-CD86, and subjected to flow cytometry analysis.
T63	2177-2240	Sentence	denotes	The populations shown in histograms were gated on CD11c+ cells.
T64	2241-2285	Sentence	denotes	Unstained cells served as negative controls.
T65	2286-2344	Sentence	denotes	Results are representative of two independent experiments.
T66	2347-2468	Sentence	denotes	BMDC from in vitro cultures functionally resemble non-lymphoid tissue DC and monocyte-derived inflammatory DC [15], [16].
T67	2469-2523	Sentence	denotes	The yields of BMDC from WT and cpdm mice were similar.
T68	2524-2622	Sentence	denotes	BMDC were CD11c+ and MHC II+ with low expression of co-stimulatory molecules CD40, CD80, and CD86.
T69	2623-2780	Sentence	denotes	The TLR3 ligand poly I:C and the TLR4 ligand LPS each activate overlapping but different signaling pathways and were used to induce DC maturation [17], [18].
T70	2781-3003	Sentence	denotes	Incubation with the TLR agonists for 24 hours resulted in increased expression of CD40, CD80, and CD86 on BMDC; however, there was no difference in the expression levels of these markers between WT and cpdm BMDC (Fig. 2B).
T71	3004-3098	Sentence	denotes	Thus, SHARPIN deficiency did not influence the expression of co-stimulatory molecules by BMDC.

events-check-again

Id	Subject	Object	Predicate	Lexical cue	Negation
T3733	172-179	Protein	denotes	Sharpin
T3734	180-188	Negative_regulation	denotes	mutation
T3735	307-312	Protein	denotes	CD11c
T3736	313-317	Protein	denotes	CD8α
T3737	323-328	Protein	denotes	CD11c
T3738	329-333	Protein	denotes	CD8α
T3739	367-372	Protein	denotes	CD11c
T3740	373-379	Protein	denotes	PDCA-1
T3741	598-605	Protein	denotes	SHARPIN
T3742	606-616	Negative_regulation	denotes	deficiency
T3743	933-940	Protein	denotes	Sharpin
T3744	941-949	Negative_regulation	denotes	mutation
T3745	2534-2539	Protein	denotes	CD11c
T3746	2601-2605	Protein	denotes	CD40
T3747	2607-2611	Protein	denotes	CD80
T3748	2617-2621	Protein	denotes	CD86
T3749	2627-2631	Protein	denotes	TLR3
T3750	2632-2638	Binding	denotes	ligand
T3751	2656-2660	Protein	denotes	TLR4
T3752	2661-2667	Binding	denotes	ligand
T3753	2827-2835	Positive_regulation	denotes	resulted
T3754	2827-2835	Positive_regulation	denotes	resulted
T3755	2827-2835	Positive_regulation	denotes	resulted
T3756	2839-2848	Positive_regulation	denotes	increased
T3757	2839-2848	Positive_regulation	denotes	increased
T3758	2839-2848	Positive_regulation	denotes	increased
T3759	2849-2859	Gene_expression	denotes	expression
T3760	2849-2859	Gene_expression	denotes	expression
T3761	2849-2859	Gene_expression	denotes	expression
T3762	2863-2867	Protein	denotes	CD40
T3763	2869-2873	Protein	denotes	CD80
T3764	2879-2883	Protein	denotes	CD86
T3765	2915-2925	Regulation	denotes	difference	true
T3766	2915-2925	Regulation	denotes	difference	true
T3767	2915-2925	Regulation	denotes	difference	true
T3768	2933-2943	Gene_expression	denotes	expression
T3769	2933-2943	Gene_expression	denotes	expression
T3770	2933-2943	Gene_expression	denotes	expression
T3771	3010-3017	Protein	denotes	SHARPIN
T3772	3018-3028	Negative_regulation	denotes	deficiency
T13792	1079-1086	Protein	denotes	Sharpin
T13793	1087-1095	Negative_regulation	denotes	mutation
R3092	T3733	T3734	themeOf	Sharpin,mutation
R3093	T3741	T3742	themeOf	SHARPIN,deficiency
R3094	T3743	T3744	themeOf	Sharpin,mutation
R3095	T3749	T3750	themeOf	TLR3,ligand
R3096	T3751	T3752	themeOf	TLR4,ligand
R3097	T3756	T3753	themeOf	increased,resulted
R3098	T3757	T3754	themeOf	increased,resulted
R3099	T3758	T3755	themeOf	increased,resulted
R3100	T3759	T3757	themeOf	expression,increased
R3101	T3760	T3758	themeOf	expression,increased
R3102	T3761	T3756	themeOf	expression,increased
R3103	T3762	T3759	themeOf	CD40,expression
R3104	T3762	T3768	themeOf	CD40,expression
R3105	T3763	T3760	themeOf	CD80,expression
R3106	T3763	T3769	themeOf	CD80,expression
R3107	T3764	T3761	themeOf	CD86,expression
R3108	T3764	T3770	themeOf	CD86,expression
R3109	T3768	T3765	themeOf	expression,difference
R3110	T3769	T3766	themeOf	expression,difference
R3111	T3770	T3767	themeOf	expression,difference
R3112	T3771	T3772	themeOf	SHARPIN,deficiency
R11497	T13792	T13793	themeOf	Sharpin,mutation

bionlp-st-ge-2016-reference

Id	Subject	Object	Predicate	Lexical cue	Negation
T3241	180-188	Negative_regulation	denotes	mutation
T3242	2827-2835	Positive_regulation	denotes	resulted
T3243	2839-2848	Positive_regulation	denotes	increased
T3244	2849-2859	Gene_expression	denotes	expression
T3245	2849-2859	Gene_expression	denotes	expression
T3246	2849-2859	Gene_expression	denotes	expression
T3247	2915-2925	Regulation	denotes	difference	true
T3248	2933-2943	Gene_expression	denotes	expression
T3249	2915-2925	Regulation	denotes	difference	true
T3250	2933-2943	Gene_expression	denotes	expression
T3251	2915-2925	Regulation	denotes	difference	true
T3252	606-616	Negative_regulation	denotes	deficiency
T3253	2933-2943	Gene_expression	denotes	expression
T3254	3018-3028	Negative_regulation	denotes	deficiency
T3255	941-949	Negative_regulation	denotes	mutation
T3256	2632-2638	Binding	denotes	ligand
T3257	2661-2667	Binding	denotes	ligand
T3258	2827-2835	Positive_regulation	denotes	resulted
T3259	2839-2848	Positive_regulation	denotes	increased
T3260	2827-2835	Positive_regulation	denotes	resulted
T3261	2839-2848	Positive_regulation	denotes	increased
T3262	172-179	Protein	denotes	Sharpin
T3263	2534-2539	Protein	denotes	CD11c
T3264	2601-2605	Protein	denotes	CD40
T3265	2607-2611	Protein	denotes	CD80
T3266	2617-2621	Protein	denotes	CD86
T3267	2627-2631	Protein	denotes	TLR3
T3268	2656-2660	Protein	denotes	TLR4
T3269	2863-2867	Protein	denotes	CD40
T3270	2869-2873	Protein	denotes	CD80
T3271	2879-2883	Protein	denotes	CD86
T3272	3010-3017	Protein	denotes	SHARPIN
T3273	307-312	Protein	denotes	CD11c
T3274	313-317	Protein	denotes	CD8α
T3275	323-328	Protein	denotes	CD11c
T3276	367-372	Protein	denotes	CD11c
T3277	373-379	Protein	denotes	PDCA-1
T3278	598-605	Protein	denotes	SHARPIN
T3279	933-940	Protein	denotes	Sharpin
T3280	329-333	Protein	denotes	CD8α
T13263	1079-1086	Protein	denotes	Sharpin
T13264	1087-1095	Negative_regulation	denotes	mutation
R11006	T13263	T13264	themeOf	Sharpin,mutation
R2686	T3243	T3242	themeOf	increased,resulted
R2687	T3244	T3259	themeOf	expression,increased
R2688	T3245	T3261	themeOf	expression,increased
R2689	T3246	T3243	themeOf	expression,increased
R2690	T3248	T3247	themeOf	expression,difference
R2691	T3250	T3249	themeOf	expression,difference
R2692	T3253	T3251	themeOf	expression,difference
R2693	T3259	T3258	themeOf	increased,resulted
R2694	T3261	T3260	themeOf	increased,resulted
R2695	T3262	T3241	themeOf	Sharpin,mutation
R2696	T3267	T3256	themeOf	TLR3,ligand
R2697	T3268	T3257	themeOf	TLR4,ligand
R2698	T3269	T3244	themeOf	CD40,expression
R2699	T3269	T3248	themeOf	CD40,expression
R2700	T3270	T3245	themeOf	CD80,expression
R2701	T3270	T3250	themeOf	CD80,expression
R2702	T3271	T3246	themeOf	CD86,expression
R2703	T3271	T3253	themeOf	CD86,expression
R2704	T3272	T3254	themeOf	SHARPIN,deficiency
R2705	T3278	T3252	themeOf	SHARPIN,deficiency
R2706	T3279	T3255	themeOf	Sharpin,mutation

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T3615	172-179	Q9H0F6	denotes	Sharpin
T3616	307-312	P20702	denotes	CD11c
T3617	323-328	P20702	denotes	CD11c
T3618	367-372	P20702	denotes	CD11c
T3619	524-529	P20702	denotes	CD11c
T3620	598-605	Q9H0F6	denotes	SHARPIN
T3621	933-940	Q9H0F6	denotes	Sharpin
T3622	2534-2539	P20702	denotes	CD11c
T3623	2601-2605	P25942	denotes	CD40
T3624	2607-2611	P33681	denotes	CD80
T3625	2617-2621	P42081	denotes	CD86
T3626	2627-2631	O15455	denotes	TLR3
T3627	2656-2660	O00206	denotes	TLR4
T3628	2863-2867	P25942	denotes	CD40
T3629	2869-2873	P33681	denotes	CD80
T3630	2879-2883	P42081	denotes	CD86
T3631	3010-3017	Q9H0F6	denotes	SHARPIN
T13754	1079-1086	Q9H0F6	denotes	Sharpin
T13755	1511-1516	P20702	denotes	CD11c
T13756	1524-1529	P20702	denotes	CD11c
T13757	1557-1562	P20702	denotes	CD11c
T13758	1650-1655	P20702	denotes	CD11c
T13759	1668-1673	P20702	denotes	CD11c
T13760	1711-1716	P20702	denotes	CD11c
T13761	1795-1800	P20702	denotes	CD11c
T13762	1811-1816	P20702	denotes	CD11c
T13763	2103-2107	P25942	denotes	CD40
T13764	2114-2118	P33681	denotes	CD80
T13765	2129-2133	P42081	denotes	CD86
T13766	2227-2232	P20702	denotes	CD11c

test2

Id	Subject	Object	Predicate	Lexical cue	Negation
T2835	172-179	Protein	denotes	Sharpin
T2836	180-188	Negative_regulation	denotes	mutation
T2837	307-312	Protein	denotes	CD11c
T2838	313-317	Protein	denotes	CD8α
T2839	323-328	Protein	denotes	CD11c
T2840	329-333	Protein	denotes	CD8α
T2841	367-372	Protein	denotes	CD11c
T2842	373-379	Protein	denotes	PDCA-1
T2843	586-594	Regulation	denotes	affected
T2844	598-605	Protein	denotes	SHARPIN
T2845	606-616	Negative_regulation	denotes	deficiency
T2846	933-940	Protein	denotes	Sharpin
T2847	941-949	Negative_regulation	denotes	mutation
T2848	2534-2539	Protein	denotes	CD11c
T2849	2562-2572	Gene_expression	denotes	expression	true
T2850	2601-2605	Protein	denotes	CD40
T2851	2607-2611	Protein	denotes	CD80	true
T2852	2617-2621	Protein	denotes	CD86
T2853	2627-2631	Protein	denotes	TLR3	true
T2854	2656-2660	Protein	denotes	TLR4
T2855	2661-2667	Binding	denotes	ligand
T2856	2827-2835	Positive_regulation	denotes	resulted
T2857	2839-2848	Positive_regulation	denotes	increased
T2858	2849-2859	Gene_expression	denotes	expression
T2859	2863-2867	Protein	denotes	CD40
T2860	2869-2873	Protein	denotes	CD80
T2861	2879-2883	Protein	denotes	CD86
T2862	3010-3017	Protein	denotes	SHARPIN
T2863	3018-3028	Negative_regulation	denotes	deficiency
T13259	1069-1075	Regulation	denotes	Effect
T13260	1079-1086	Protein	denotes	Sharpin
T13261	1087-1095	Negative_regulation	denotes	mutation
R2318	T2835	T2836	themeOf	Sharpin,mutation
R2319	T2844	T2845	themeOf	SHARPIN,deficiency
R2320	T2845	T2843	causeOf	deficiency,affected
R2321	T2846	T2847	themeOf	Sharpin,mutation
R2322	T2853	T2855	themeOf	TLR3,ligand
R2323	T2854	T2855	themeOf	TLR4,ligand
R2324	T2857	T2856	themeOf	increased,resulted
R2325	T2858	T2857	themeOf	expression,increased
R2326	T2859	T2858	themeOf	CD40,expression
R2327	T2860	T2858	themeOf	CD80,expression
R2328	T2861	T2858	themeOf	CD86,expression
R2329	T2862	T2863	themeOf	SHARPIN,deficiency
R11005	T13260	T13261	themeOf	Sharpin,mutation

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