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2_test

Id Subject Object Predicate Lexical cue
22348129-2031185-89575671 163-165 2031185 denotes 11
22348129-17545200-89575672 182-184 17545200 denotes 12
22348129-8362989-89575673 770-771 8362989 denotes 3
T88551 163-165 2031185 denotes 11
T69510 182-184 17545200 denotes 12
T81551 770-771 8362989 denotes 3

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T2461 0-16 NN denotes Characterization
T2462 17-19 IN denotes of
T2463 20-27 NNP denotes Sharpin
T2464 29-38 NN denotes Orthologs
T2465 39-41 IN denotes of
T2466 42-49 NN denotes SHARPIN
T2467 50-57 NN denotes protein
T2468 58-61 VB denotes are
T2469 62-67 VB denotes found
T2470 68-70 IN denotes in
T2471 71-78 JJ denotes various
T2472 79-86 NN denotes species
T2473 86-87 -COMMA- denotes ,
T2474 88-97 VB denotes including
T2475 98-103 JJ denotes human
T2476 103-104 -COMMA- denotes ,
T2477 105-110 NN denotes mouse
T2478 111-114 CC denotes and
T2479 115-118 NN denotes rat
T2480 120-125 NN denotes Motif
T2481 126-136 NN denotes prediction
T2482 137-148 NN denotes programming
T2483 148-149 -COMMA- denotes ,
T2484 150-155 VB denotes using
T2485 156-161 NN denotes COILS
T2486 162-163 -LRB- denotes [
T2487 163-165 CD denotes 11
T2488 165-166 -RRB- denotes ]
T2489 167-170 CC denotes and
T2490 171-180 NNP denotes MotifScan
T2491 181-182 -LRB- denotes [
T2492 182-184 CD denotes 12
T2493 184-185 -RRB- denotes ]
T2494 185-186 -COMMA- denotes ,
T2495 187-195 VB denotes suggests
T2496 196-200 IN denotes that
T2497 201-208 NN denotes SHARPIN
T2498 209-217 VB denotes contains
T2499 218-219 DT denotes a
T2500 220-231 NN denotes coiled-coil
T2501 232-233 -LRB- denotes (
T2502 233-235 NN denotes CC
T2503 235-236 -RRB- denotes )
T2504 237-243 NN denotes domain
T2505 243-244 -COMMA- denotes ,
T2506 245-246 DT denotes a
T2507 247-261 JJ denotes ubiquitin-like
T2508 262-263 -LRB- denotes (
T2509 263-266 NN denotes UBL
T2510 266-267 -RRB- denotes )
T2511 268-274 NN denotes domain
T2512 274-275 -COMMA- denotes ,
T2513 276-279 CC denotes and
T2514 280-281 DT denotes a
T2515 282-293 JJ denotes zinc-finger
T2516 294-305 JJ denotes Ran-binding
T2517 306-313 NN denotes protein
T2518 314-315 CD denotes 2
T2519 316-317 -LRB- denotes (
T2520 317-322 NN denotes ZFRBP
T2521 322-323 -RRB- denotes )
T2522 324-330 NN denotes domain
T2523 332-337 DT denotes These
T2524 338-348 JJ denotes functional
T2525 349-355 NN denotes motifs
T2526 356-366 VB denotes constitute
T2527 367-374 JJ denotes similar
T2528 375-381 NN denotes domain
T2529 382-390 NN denotes profiles
T2530 391-395 WDT denotes that
T2531 396-399 VB denotes are
T2532 400-407 JJ denotes present
T2533 408-410 IN denotes in
T2534 411-414 DT denotes the
T2535 415-422 NN denotes SHARPIN
T2536 423-430 NN denotes protein
T2537 431-433 IN denotes of
T2538 434-437 DT denotes all
T2539 438-443 CD denotes three
T2540 444-451 NN denotes origins
T2541 452-453 -LRB- denotes (
T2542 453-457 NNP denotes Fig.
T2543 458-460 NN denotes 1A
T2544 460-461 -RRB- denotes )
T2545 461-462 -COMMA- denotes ,
T2546 463-473 VB denotes suggesting
T2547 474-478 IN denotes that
T2548 479-486 NN denotes SHARPIN
T2549 487-493 NN denotes exerts
T2550 494-500 RB denotes highly
T2551 501-510 VB denotes conserved
T2552 511-520 NN denotes functions
T2553 521-527 IN denotes across
T2554 528-535 NN denotes species
T2555 537-548 JJ denotes Spontaneous
T2556 549-558 NN denotes mutations
T2557 559-561 IN denotes in
T2558 562-565 DT denotes the
T2559 566-571 NN denotes mouse
T2560 572-579 NN denotes Sharpin
T2561 580-584 NN denotes gene
T2562 585-592 VB denotes results
T2563 593-595 IN denotes in
T2564 596-597 DT denotes a
T2565 598-605 JJ denotes complex
T2566 606-618 JJ denotes inflammatory
T2567 619-628 NN denotes phenotype
T2568 629-642 VB denotes characterized
T2569 643-645 IN denotes by
T2570 646-652 JJ denotes severe
T2571 653-663 NN denotes dermatitis
T2572 664-665 -LRB- denotes (
T2573 665-669 NN denotes Fig.
T2574 670-672 NN denotes 1B
T2575 672-673 -RRB- denotes )
T2576 673-674 -COMMA- denotes ,
T2577 675-683 JJ denotes systemic
T2578 684-696 NN denotes inflammation
T2579 697-700 CC denotes and
T2580 701-703 DT denotes an
T2581 704-712 JJ denotes enlarged
T2582 713-719 NN denotes spleen
T2583 720-721 -LRB- denotes (
T2584 721-725 NN denotes Fig.
T2585 726-728 NN denotes 1C
T2586 728-729 -RRB- denotes )
T2587 730-736 VB denotes caused
T2588 737-739 IN denotes by
T2589 740-754 JJ denotes extramedullary
T2590 755-768 NN denotes hematopoiesis
T2591 769-770 -LRB- denotes [
T2592 770-771 CD denotes 3
T2593 771-772 -RRB- denotes ]
T2594 774-777 DT denotes The
T2595 778-788 JJ denotes endogenous
T2596 789-799 NN denotes expression
T2597 800-802 IN denotes of
T2598 803-810 NN denotes Sharpin
T2599 811-815 NN denotes mRNA
T2600 816-818 IN denotes in
T2601 819-823 NN denotes BMDC
T2602 824-827 VB denotes was
T2603 828-838 VB denotes determined
T2604 839-841 IN denotes by
T2605 842-854 JJ denotes quantitative
T2606 855-859 JJ denotes real
T2607 860-868 NN denotes time-PCR
T2608 869-870 -LRB- denotes (
T2609 870-877 NN denotes qRT-PCR
T2610 877-878 -RRB- denotes )
T2611 879-888 VB denotes following
T2612 889-896 NN denotes culture
T2613 897-899 IN denotes in
T2614 900-906 NN denotes medium
T2615 907-911 RB denotes only
T2616 912-914 CC denotes or
T2617 915-920 IN denotes after
T2618 921-932 NN denotes stimulation
T2619 933-937 IN denotes with
T2620 938-941 NN denotes LPS
T2621 943-950 NN denotes Sharpin
T2622 951-955 NN denotes mRNA
T2623 956-959 VB denotes was
T2624 960-967 JJ denotes present
T2625 968-970 IN denotes in
T2626 971-975 NN denotes BMDC
T2627 976-985 VB denotes generated
T2628 986-990 IN denotes from
T2629 991-993 JJ denotes WT
T2630 994-998 NN denotes mice
T2631 999-1000 -LRB- denotes (
T2632 1000-1004 NNP denotes Fig.
T2633 1005-1007 NN denotes 1D
T2634 1007-1008 -RRB- denotes )
T2635 1009-1012 CC denotes and
T2636 1013-1016 PRP-DOLLAR- denotes its
T2637 1017-1022 NN denotes level
T2638 1023-1026 VB denotes was
T2639 1027-1035 RB denotes modestly
T2640 1036-1045 VB denotes decreased
T2641 1046-1048 IN denotes by
T2642 1049-1052 NN denotes LPS
T2643 1053-1064 NN denotes stimulation
T2644 1066-1071 EX denotes There
T2645 1072-1075 VB denotes was
T2646 1076-1077 DT denotes a
T2647 1078-1089 JJ denotes significant
T2648 1090-1099 NN denotes reduction
T2649 1100-1102 IN denotes of
T2650 1103-1110 NN denotes Sharpin
T2651 1111-1115 NN denotes mRNA
T2652 1116-1117 -LRB- denotes (
T2653 1117-1125 JJ denotes 6–7-fold
T2654 1125-1126 -RRB- denotes )
T2655 1127-1129 IN denotes in
T2656 1130-1134 NN denotes BMDC
T2657 1135-1144 VB denotes generated
T2658 1145-1149 IN denotes from
T2659 1150-1154 NN denotes cpdm
T2660 1155-1159 NN denotes mice
T2661 1161-1173 NN denotes Transfection
T2662 1174-1176 IN denotes of
T2663 1177-1188 JJ denotes Flag-tagged
T2664 1189-1196 NNP denotes Sharpin
T2665 1197-1199 IN denotes in
T2666 1200-1211 NN denotes fibroblasts
T2667 1212-1213 -LRB- denotes (
T2668 1213-1219 NN denotes NIH3T3
T2669 1219-1220 -RRB- denotes )
T2670 1221-1224 CC denotes and
T2671 1225-1236 NN denotes macrophages
T2672 1237-1238 -LRB- denotes (
T2673 1238-1246 NN denotes RAW264.7
T2674 1246-1247 -RRB- denotes )
T2675 1248-1257 VB denotes indicated
T2676 1258-1269 JJ denotes cytoplasmic
T2677 1270-1282 NN denotes localization
T2678 1283-1285 IN denotes of
T2679 1286-1289 DT denotes the
T2680 1290-1297 NN denotes SHARPIN
T2681 1298-1305 NN denotes protein
T2682 1306-1307 -LRB- denotes (
T2683 1307-1311 NN denotes Fig.
T2684 1312-1314 NN denotes 1E
T2685 1314-1315 -RRB- denotes )
T12991 1361-1363 FW denotes In
T12992 1364-1368 FW denotes vivo
T12993 1369-1372 CC denotes and
T12994 1373-1375 FW denotes in
T12995 1376-1381 FW denotes vitro
T12996 1382-1390 NN denotes features
T12997 1391-1393 IN denotes of
T12998 1394-1401 NN denotes SHARPIN
T12999 1403-1404 -LRB- denotes (
T13000 1404-1405 NN denotes A
T13001 1405-1406 -RRB- denotes )
T13002 1407-1412 NN denotes COILS
T13003 1413-1416 CC denotes and
T13004 1417-1426 NNP denotes MotifScan
T13005 1427-1435 NN denotes programs
T13006 1436-1440 VB denotes were
T13007 1441-1445 VB denotes used
T13008 1446-1448 TO denotes to
T13009 1449-1456 VB denotes predict
T13010 1457-1460 DT denotes the
T13011 1461-1469 NN denotes presence
T13012 1470-1472 IN denotes of
T13013 1473-1475 NN denotes CC
T13014 1476-1477 -LRB- denotes (
T13015 1477-1488 NN denotes coiled-coil
T13016 1488-1489 -RRB- denotes )
T13017 1490-1496 NN denotes domain
T13018 1496-1497 -COMMA- denotes ,
T13019 1498-1501 NN denotes UBL
T13020 1502-1503 -LRB- denotes (
T13021 1503-1517 JJ denotes ubiquitin-like
T13022 1517-1518 -RRB- denotes )
T13023 1519-1525 NN denotes domain
T13024 1526-1529 CC denotes and
T13025 1530-1535 NN denotes ZFRBP
T13026 1536-1537 -LRB- denotes (
T13027 1537-1548 NN denotes zinc-finger
T13028 1549-1560 NN denotes Ran-Binding
T13029 1561-1568 NN denotes protein
T13030 1569-1570 CD denotes 2
T13031 1570-1571 -RRB- denotes )
T13032 1572-1578 NN denotes domain
T13033 1579-1584 WDT denotes which
T13034 1585-1589 VB denotes form
T13035 1590-1597 JJ denotes similar
T13036 1598-1603 NN denotes motif
T13037 1604-1612 NN denotes patterns
T13038 1613-1615 IN denotes in
T13039 1616-1619 DT denotes the
T13040 1620-1627 NN denotes SHARPIN
T13041 1628-1635 NN denotes protein
T13042 1636-1638 IN denotes of
T13043 1639-1644 JJ denotes human
T13044 1644-1645 -COMMA- denotes ,
T13045 1646-1651 NN denotes mouse
T13046 1652-1655 CC denotes and
T13047 1656-1659 NN denotes rat
T13048 1660-1668 NN denotes origins.
T13049 1669-1670 -LRB- denotes (
T13050 1670-1671 NN denotes B
T13051 1671-1672 -RRB- denotes )
T13052 1673-1678 CD denotes Eight
T13053 1679-1687 JJ denotes week-old
T13054 1688-1695 NN denotes females
T13055 1696-1698 IN denotes of
T13056 1699-1701 NN denotes WT
T13057 1702-1705 CC denotes and
T13058 1706-1710 NN denotes cpdm
T13059 1711-1715 NN denotes mice
T13060 1717-1720 DT denotes The
T13061 1721-1727 JJ denotes mutant
T13062 1728-1732 NN denotes mice
T13063 1733-1734 -LRB- denotes (
T13064 1734-1739 IN denotes above
T13065 1739-1740 -RRB- denotes )
T13066 1741-1748 VB denotes develop
T13067 1749-1760 JJ denotes progressive
T13068 1761-1765 NN denotes skin
T13069 1766-1778 NN denotes inflammation
T13070 1779-1787 VB denotes starting
T13071 1788-1790 IN denotes at
T13072 1791-1796 IN denotes about
T13073 1797-1801 CD denotes four
T13074 1802-1808 NN denotes weeks.
T13075 1809-1810 -LRB- denotes (
T13076 1810-1811 NN denotes C
T13077 1811-1812 -RRB- denotes )
T13078 1813-1827 JJ denotes Extramedullary
T13079 1828-1841 NN denotes hematopoiesis
T13080 1842-1848 VB denotes causes
T13081 1849-1855 JJ denotes marked
T13082 1856-1867 NN denotes enlargement
T13083 1868-1870 IN denotes of
T13084 1871-1874 DT denotes the
T13085 1875-1881 NN denotes spleen
T13086 1882-1884 IN denotes of
T13087 1885-1889 NN denotes cpdm
T13088 1890-1895 NN denotes mice.
T13089 1896-1897 -LRB- denotes (
T13090 1897-1898 NN denotes D
T13091 1898-1899 -RRB- denotes )
T13092 1900-1904 NN denotes BMDC
T13093 1905-1909 VB denotes were
T13094 1910-1919 VB denotes incubated
T13095 1920-1922 IN denotes in
T13096 1923-1926 DT denotes the
T13097 1927-1934 NN denotes absence
T13098 1935-1937 CC denotes or
T13099 1938-1946 NN denotes presence
T13100 1947-1949 IN denotes of
T13101 1950-1953 CD denotes 100
T13102 1954-1959 NN denotes ng/ml
T13103 1960-1963 NN denotes LPS
T13104 1964-1967 IN denotes for
T13105 1968-1969 CD denotes 4
T13106 1970-1975 NN denotes hours
T13107 1977-1980 DT denotes The
T13108 1981-1985 NN denotes mRNA
T13109 1986-1991 NN denotes level
T13110 1992-1994 IN denotes of
T13111 1995-2002 NN denotes Sharpin
T13112 2003-2006 VB denotes was
T13113 2007-2015 VB denotes measured
T13114 2016-2018 IN denotes by
T13115 2019-2026 NN denotes qRT-PCR
T13116 2027-2030 CC denotes and
T13117 2031-2040 VB denotes presented
T13118 2041-2049 JJ denotes relative
T13119 2050-2052 TO denotes to
T13120 2053-2056 DT denotes the
T13121 2057-2061 NN denotes mRNA
T13122 2062-2072 NN denotes expression
T13123 2073-2075 IN denotes in
T13124 2076-2090 JJ denotes non-stimulated
T13125 2091-2093 NNP denotes WT
T13126 2094-2098 NN denotes BMDC
T13127 2100-2104 NN denotes Bars
T13128 2105-2114 VB denotes represent
T13129 2115-2118 DT denotes the
T13130 2119-2123 JJ denotes mean
T13131 2124-2125 JJ denotes ±
T13132 2126-2130 NN denotes s.d.
T13133 2131-2133 IN denotes of
T13134 2134-2135 CD denotes 3
T13135 2136-2141 NN denotes mice.
T13136 2142-2143 SYM denotes *
T13137 2144-2145 NN denotes P
T13138 2145-2146 SYM denotes <
T13139 2146-2150 CD denotes 0.05
T13140 2150-2151 -COLON- denotes ;
T13141 2152-2154 SYM denotes **
T13142 2155-2156 NN denotes P
T13143 2156-2157 SYM denotes <
T13144 2157-2163 CD denotes 0.001.
T13145 2164-2165 -LRB- denotes (
T13146 2165-2166 NN denotes E
T13147 2166-2167 -RRB- denotes )
T13148 2168-2178 NN denotes Fibroblast
T13149 2179-2180 -LRB- denotes (
T13150 2180-2186 NN denotes NIH3T3
T13151 2186-2187 -RRB- denotes )
T13152 2188-2191 CC denotes and
T13153 2192-2203 NN denotes macrophages
T13154 2204-2205 -LRB- denotes (
T13155 2205-2213 NN denotes RAW264.7
T13156 2213-2214 -RRB- denotes )
T13157 2215-2220 NN denotes cells
T13158 2221-2225 VB denotes were
T13159 2226-2237 VB denotes transfected
T13160 2238-2242 IN denotes with
T13161 2243-2246 DT denotes the
T13162 2247-2257 NN denotes expression
T13163 2258-2265 NN denotes plasmid
T13164 2266-2279 NN denotes pFLAG-SHARPIN
T13165 2281-2286 IN denotes After
T13166 2287-2289 CD denotes 48
T13167 2290-2295 NN denotes hours
T13168 2295-2296 -COMMA- denotes ,
T13169 2297-2302 NN denotes cells
T13170 2303-2307 VB denotes were
T13171 2308-2313 VB denotes fixed
T13172 2314-2317 CC denotes and
T13173 2318-2324 VB denotes probed
T13174 2325-2329 IN denotes with
T13175 2330-2339 JJ denotes anti-FLAG
T13176 2340-2343 CC denotes and
T13177 2344-2359 JJ denotes FITC-conjugated
T13178 2360-2369 JJ denotes secondary
T13179 2370-2378 NN denotes antibody
T13180 2380-2386 NN denotes Nuclei
T13181 2387-2391 VB denotes were
T13182 2392-2399 VB denotes stained
T13183 2400-2404 IN denotes with
T13184 2405-2409 NNP denotes DAPI
T13185 2411-2413 IN denotes In
T13186 2414-2418 DT denotes both
T13187 2419-2430 VB denotes transfected
T13188 2431-2435 NN denotes cell
T13189 2436-2441 NN denotes lines
T13190 2441-2442 -COMMA- denotes ,
T13191 2443-2455 NN denotes FLAG-SHARPIN
T13192 2456-2459 VB denotes was
T13193 2460-2465 VB denotes found
T13194 2466-2468 TO denotes to
T13195 2469-2471 VB denotes be
T13196 2472-2491 JJ denotes cytoplasm-localized
R2041 T2461 T2462 arg1Of Characterization,of
R2042 T2463 T2462 arg2Of Sharpin,of
R2043 T2464 T2465 arg1Of Orthologs,of
R2044 T2464 T2468 arg1Of Orthologs,are
R2045 T2464 T2469 arg2Of Orthologs,found
R2046 T2467 T2465 arg2Of protein,of
R2047 T2467 T2466 arg1Of protein,SHARPIN
R2048 T2469 T2468 arg2Of found,are
R2049 T2469 T2470 arg1Of found,in
R2050 T2472 T2470 arg2Of species,in
R2051 T2472 T2471 arg1Of species,various
R2052 T2472 T2473 arg1Of species,","
R2053 T2472 T2474 arg1Of species,including
R2054 T2475 T2476 arg1Of human,","
R2055 T2477 T2478 arg1Of mouse,and
R2056 T2478 T2474 arg2Of and,including
R2057 T2478 T2475 arg1Of and,human
R2058 T2479 T2478 arg2Of rat,and
R2059 T2482 T2480 arg1Of programming,Motif
R2060 T2482 T2481 arg1Of programming,prediction
R2061 T2482 T2495 arg1Of programming,suggests
R2062 T2485 T2486 arg1Of COILS,[
R2063 T2485 T2489 arg1Of COILS,and
R2064 T2487 T2486 arg2Of 11,[
R2065 T2488 T2486 arg3Of ],[
R2066 T2489 T2484 arg2Of and,using
R2067 T2490 T2489 arg2Of MotifScan,and
R2068 T2490 T2491 arg1Of MotifScan,[
R2069 T2492 T2491 arg2Of 12,[
R2070 T2493 T2491 arg3Of ],[
R2071 T2495 T2483 arg1Of suggests,","
R2072 T2495 T2484 modOf suggests,using
R2073 T2495 T2494 arg1Of suggests,","
R2074 T2497 T2498 arg1Of SHARPIN,contains
R2075 T2498 T2495 arg2Of contains,suggests
R2076 T2498 T2496 arg1Of contains,that
R2077 T2502 T2501 arg2Of CC,(
R2078 T2503 T2501 arg3Of ),(
R2079 T2504 T2499 arg1Of domain,a
R2080 T2504 T2500 arg1Of domain,coiled-coil
R2081 T2504 T2501 arg1Of domain,(
R2082 T2504 T2505 arg1Of domain,","
R2083 T2504 T2513 arg1Of domain,and
R2084 T2507 T2508 arg1Of ubiquitin-like,(
R2085 T2509 T2508 arg2Of UBL,(
R2086 T2510 T2508 arg3Of ),(
R2087 T2511 T2505 arg2Of domain,","
R2088 T2511 T2506 arg1Of domain,a
R2089 T2511 T2507 arg1Of domain,ubiquitin-like
R2090 T2513 T2498 arg2Of and,contains
R2091 T2513 T2512 arg1Of and,","
R2092 T2520 T2519 arg2Of ZFRBP,(
R2093 T2521 T2519 arg3Of ),(
R2094 T2522 T2513 arg2Of domain,and
R2095 T2522 T2514 arg1Of domain,a
R2096 T2522 T2515 arg1Of domain,zinc-finger
R2097 T2522 T2516 arg1Of domain,Ran-binding
R2098 T2522 T2517 arg1Of domain,protein
R2099 T2522 T2518 arg1Of domain,2
R2100 T2522 T2519 arg1Of domain,(
R2101 T2525 T2523 arg1Of motifs,These
R2102 T2525 T2524 arg1Of motifs,functional
R2103 T2525 T2526 arg1Of motifs,constitute
R2104 T2526 T2545 arg1Of constitute,","
R2105 T2526 T2546 modOf constitute,suggesting
R2106 T2529 T2526 arg2Of profiles,constitute
R2107 T2529 T2527 arg1Of profiles,similar
R2108 T2529 T2528 arg1Of profiles,domain
R2109 T2529 T2530 arg1Of profiles,that
R2110 T2529 T2531 arg1Of profiles,are
R2111 T2529 T2532 arg1Of profiles,present
R2112 T2532 T2531 arg2Of present,are
R2113 T2532 T2533 arg1Of present,in
R2114 T2536 T2533 arg2Of protein,in
R2115 T2536 T2534 arg1Of protein,the
R2116 T2536 T2535 arg1Of protein,SHARPIN
R2117 T2536 T2537 arg1Of protein,of
R2118 T2540 T2537 arg2Of origins,of
R2119 T2540 T2538 arg1Of origins,all
R2120 T2540 T2539 arg1Of origins,three
R2121 T2540 T2541 arg1Of origins,(
R2122 T2543 T2541 arg2Of 1A,(
R2123 T2543 T2542 arg1Of 1A,Fig.
R2124 T2544 T2541 arg3Of ),(
R2125 T2546 T2553 arg1Of suggesting,across
R2126 T2548 T2549 arg1Of SHARPIN,exerts
R2127 T2549 T2546 arg2Of exerts,suggesting
R2128 T2549 T2547 arg1Of exerts,that
R2129 T2552 T2549 arg2Of functions,exerts
R2130 T2552 T2550 arg1Of functions,highly
R2131 T2552 T2551 arg2Of functions,conserved
R2132 T2554 T2553 arg2Of species,across
R2133 T2556 T2555 arg1Of mutations,Spontaneous
R2134 T2556 T2557 arg1Of mutations,in
R2135 T2556 T2562 arg1Of mutations,results
R2136 T2561 T2557 arg2Of gene,in
R2137 T2561 T2558 arg1Of gene,the
R2138 T2561 T2559 arg1Of gene,mouse
R2139 T2561 T2560 arg1Of gene,Sharpin
R2140 T2562 T2563 arg1Of results,in
R2141 T2566 T2565 arg1Of inflammatory,complex
R2142 T2567 T2563 arg2Of phenotype,in
R2143 T2567 T2564 arg1Of phenotype,a
R2144 T2567 T2566 arg1Of phenotype,inflammatory
R2145 T2567 T2568 arg2Of phenotype,characterized
R2146 T2571 T2570 arg1Of dermatitis,severe
R2147 T2571 T2572 arg1Of dermatitis,(
R2148 T2571 T2576 arg1Of dermatitis,","
R2149 T2574 T2572 arg2Of 1B,(
R2150 T2574 T2573 arg1Of 1B,Fig.
R2151 T2575 T2572 arg3Of ),(
R2152 T2576 T2579 arg1Of ",",and
R2153 T2578 T2576 arg2Of inflammation,","
R2154 T2578 T2577 arg1Of inflammation,systemic
R2155 T2579 T2568 arg1Of and,characterized
R2156 T2579 T2569 arg2Of and,by
R2157 T2582 T2579 arg2Of spleen,and
R2158 T2582 T2580 arg1Of spleen,an
R2159 T2582 T2581 arg1Of spleen,enlarged
R2160 T2582 T2583 arg1Of spleen,(
R2161 T2582 T2587 arg2Of spleen,caused
R2162 T2585 T2583 arg2Of 1C,(
R2163 T2585 T2584 arg1Of 1C,Fig.
R2164 T2586 T2583 arg3Of ),(
R2165 T2590 T2587 arg1Of hematopoiesis,caused
R2166 T2590 T2588 arg2Of hematopoiesis,by
R2167 T2590 T2589 arg1Of hematopoiesis,extramedullary
R2168 T2590 T2591 arg1Of hematopoiesis,[
R2169 T2592 T2591 arg2Of 3,[
R2170 T2593 T2591 arg3Of ],[
R2171 T2596 T2594 arg1Of expression,The
R2172 T2596 T2595 arg1Of expression,endogenous
R2173 T2596 T2597 arg1Of expression,of
R2174 T2596 T2600 arg1Of expression,in
R2175 T2596 T2602 arg1Of expression,was
R2176 T2596 T2603 arg2Of expression,determined
R2177 T2599 T2597 arg2Of mRNA,of
R2178 T2599 T2598 arg1Of mRNA,Sharpin
R2179 T2601 T2600 arg2Of BMDC,in
R2180 T2603 T2602 arg2Of determined,was
R2181 T2603 T2611 arg1Of determined,following
R2182 T2603 T2613 arg1Of determined,in
R2183 T2607 T2603 arg1Of time-PCR,determined
R2184 T2607 T2604 arg2Of time-PCR,by
R2185 T2607 T2605 arg1Of time-PCR,quantitative
R2186 T2607 T2606 arg1Of time-PCR,real
R2187 T2607 T2608 arg1Of time-PCR,(
R2188 T2609 T2608 arg2Of qRT-PCR,(
R2189 T2610 T2608 arg3Of ),(
R2190 T2612 T2611 arg2Of culture,following
R2191 T2614 T2613 arg2Of medium,in
R2192 T2615 T2616 arg1Of only,or
R2193 T2616 T2613 arg3Of or,in
R2194 T2617 T2616 arg2Of after,or
R2195 T2618 T2617 arg2Of stimulation,after
R2196 T2618 T2619 arg1Of stimulation,with
R2197 T2620 T2619 arg2Of LPS,with
R2198 T2622 T2621 arg1Of mRNA,Sharpin
R2199 T2622 T2623 arg1Of mRNA,was
R2200 T2622 T2624 arg1Of mRNA,present
R2201 T2623 T2635 arg1Of was,and
R2202 T2624 T2623 arg2Of present,was
R2203 T2624 T2625 arg1Of present,in
R2204 T2626 T2625 arg2Of BMDC,in
R2205 T2626 T2627 arg2Of BMDC,generated
R2206 T2627 T2628 arg1Of generated,from
R2207 T2627 T2631 arg1Of generated,(
R2208 T2630 T2628 arg2Of mice,from
R2209 T2630 T2629 arg1Of mice,WT
R2210 T2633 T2631 arg2Of 1D,(
R2211 T2633 T2632 arg1Of 1D,Fig.
R2212 T2634 T2631 arg3Of ),(
R2213 T2637 T2636 arg1Of level,its
R2214 T2637 T2638 arg1Of level,was
R2215 T2637 T2640 arg2Of level,decreased
R2216 T2640 T2635 arg2Of decreased,and
R2217 T2640 T2638 arg2Of decreased,was
R2218 T2640 T2639 arg1Of decreased,modestly
R2219 T2640 T2641 arg1Of decreased,by
R2220 T2643 T2641 arg2Of stimulation,by
R2221 T2643 T2642 arg1Of stimulation,LPS
R2222 T2644 T2645 arg1Of There,was
R2223 T2645 T2655 arg1Of was,in
R2224 T2648 T2645 arg2Of reduction,was
R2225 T2648 T2646 arg1Of reduction,a
R2226 T2648 T2647 arg1Of reduction,significant
R2227 T2648 T2649 arg1Of reduction,of
R2228 T2651 T2649 arg2Of mRNA,of
R2229 T2651 T2650 arg1Of mRNA,Sharpin
R2230 T2651 T2652 arg1Of mRNA,(
R2231 T2653 T2652 arg2Of 6–7-fold,(
R2232 T2654 T2652 arg3Of ),(
R2233 T2656 T2655 arg2Of BMDC,in
R2234 T2656 T2657 arg2Of BMDC,generated
R2235 T2657 T2658 arg1Of generated,from
R2236 T2660 T2658 arg2Of mice,from
R2237 T2660 T2659 arg1Of mice,cpdm
R2238 T2661 T2662 arg1Of Transfection,of
R2239 T2661 T2665 arg1Of Transfection,in
R2240 T2661 T2675 arg1Of Transfection,indicated
R2241 T2664 T2662 arg2Of Sharpin,of
R2242 T2664 T2663 arg1Of Sharpin,Flag-tagged
R2243 T2666 T2667 arg1Of fibroblasts,(
R2244 T2666 T2670 arg1Of fibroblasts,and
R2245 T2668 T2667 arg2Of NIH3T3,(
R2246 T2669 T2667 arg3Of ),(
R2247 T2670 T2665 arg2Of and,in
R2248 T2671 T2670 arg2Of macrophages,and
R2249 T2671 T2672 arg1Of macrophages,(
R2250 T2673 T2672 arg2Of RAW264.7,(
R2251 T2674 T2672 arg3Of ),(
R2252 T2677 T2675 arg2Of localization,indicated
R2253 T2677 T2676 arg1Of localization,cytoplasmic
R2254 T2677 T2678 arg1Of localization,of
R2255 T2681 T2678 arg2Of protein,of
R2256 T2681 T2679 arg1Of protein,the
R2257 T2681 T2680 arg1Of protein,SHARPIN
R2258 T2681 T2682 arg1Of protein,(
R2259 T2684 T2682 arg2Of 1E,(
R2260 T2684 T2683 arg1Of 1E,Fig.
R2261 T2685 T2682 arg3Of ),(
R10778 T12992 T12991 arg1Of vivo,In
R10779 T12992 T12993 arg1Of vivo,and
R10780 T12995 T12993 arg2Of vitro,and
R10781 T12995 T12994 arg1Of vitro,in
R10782 T12996 T12992 arg1Of features,vivo
R10783 T12996 T12995 arg1Of features,vitro
R10784 T12996 T12997 arg1Of features,of
R10785 T12998 T12997 arg2Of SHARPIN,of
R10786 T13000 T12999 arg2Of A,(
R10787 T13001 T12999 arg3Of ),(
R10788 T13002 T13003 arg1Of COILS,and
R10789 T13004 T13003 arg2Of MotifScan,and
R10790 T13005 T12999 arg1Of programs,(
R10791 T13005 T13002 arg1Of programs,COILS
R10792 T13005 T13004 arg1Of programs,MotifScan
R10793 T13005 T13006 arg1Of programs,were
R10794 T13005 T13007 arg2Of programs,used
R10795 T13007 T13006 arg2Of used,were
R10796 T13009 T13007 arg3Of predict,used
R10797 T13009 T13008 arg1Of predict,to
R10798 T13011 T13009 arg2Of presence,predict
R10799 T13011 T13010 arg1Of presence,the
R10800 T13011 T13012 arg1Of presence,of
R10801 T13015 T13014 arg2Of coiled-coil,(
R10802 T13016 T13014 arg3Of ),(
R10803 T13017 T13013 arg1Of domain,CC
R10804 T13017 T13014 arg1Of domain,(
R10805 T13017 T13018 arg1Of domain,","
R10806 T13018 T13024 arg1Of ",",and
R10807 T13021 T13020 arg2Of ubiquitin-like,(
R10808 T13022 T13020 arg3Of ),(
R10809 T13023 T13018 arg2Of domain,","
R10810 T13023 T13019 arg1Of domain,UBL
R10811 T13023 T13020 arg1Of domain,(
R10812 T13024 T13012 arg2Of and,of
R10813 T13024 T13033 arg1Of and,which
R10814 T13024 T13034 arg1Of and,form
R10815 T13025 T13026 arg1Of ZFRBP,(
R10816 T13029 T13026 arg2Of protein,(
R10817 T13029 T13027 arg1Of protein,zinc-finger
R10818 T13029 T13028 arg1Of protein,Ran-Binding
R10819 T13029 T13030 arg1Of protein,2
R10820 T13031 T13026 arg3Of ),(
R10821 T13032 T13024 arg2Of domain,and
R10822 T13032 T13025 arg1Of domain,ZFRBP
R10823 T13037 T13034 arg2Of patterns,form
R10824 T13037 T13035 arg1Of patterns,similar
R10825 T13037 T13036 arg1Of patterns,motif
R10826 T13037 T13038 arg1Of patterns,in
R10827 T13037 T13042 arg1Of patterns,of
R10828 T13041 T13038 arg2Of protein,in
R10829 T13041 T13039 arg1Of protein,the
R10830 T13041 T13040 arg1Of protein,SHARPIN
R10831 T13043 T13044 arg1Of human,","
R10832 T13045 T13046 arg1Of mouse,and
R10833 T13046 T13044 arg2Of and,","
R10834 T13048 T13046 arg2Of origins.,and
R10835 T13048 T13047 arg1Of origins.,rat
R10836 T13048 T13049 arg1Of origins.,(
R10837 T13050 T13049 arg2Of B,(
R10838 T13051 T13049 arg3Of ),(
R10839 T13054 T13042 arg2Of females,of
R10840 T13054 T13043 arg1Of females,human
R10841 T13054 T13045 arg1Of females,mouse
R10842 T13054 T13048 arg1Of females,origins.
R10843 T13054 T13052 arg1Of females,Eight
R10844 T13054 T13053 arg1Of females,week-old
R10845 T13054 T13055 arg1Of females,of
R10846 T13056 T13057 arg1Of WT,and
R10847 T13058 T13057 arg2Of cpdm,and
R10848 T13059 T13055 arg2Of mice,of
R10849 T13059 T13056 arg1Of mice,WT
R10850 T13059 T13058 arg1Of mice,cpdm
R10851 T13062 T13060 arg1Of mice,The
R10852 T13062 T13061 arg1Of mice,mutant
R10853 T13062 T13066 arg1Of mice,develop
R10854 T13066 T13063 arg1Of develop,(
R10855 T13066 T13064 arg1Of develop,above
R10856 T13066 T13065 arg1Of develop,)
R10857 T13069 T13066 arg2Of inflammation,develop
R10858 T13069 T13067 arg1Of inflammation,progressive
R10859 T13069 T13068 arg1Of inflammation,skin
R10860 T13069 T13070 arg1Of inflammation,starting
R10861 T13070 T13071 arg1Of starting,at
R10862 T13073 T13072 arg1Of four,about
R10863 T13074 T13073 arg1Of weeks.,four
R10864 T13074 T13075 arg1Of weeks.,(
R10865 T13076 T13075 arg2Of C,(
R10866 T13077 T13075 arg3Of ),(
R10867 T13078 T13074 arg1Of Extramedullary,weeks.
R10868 T13080 T13071 arg2Of causes,at
R10869 T13080 T13078 arg1Of causes,Extramedullary
R10870 T13080 T13079 arg1Of causes,hematopoiesis
R10871 T13080 T13093 modOf causes,were
R10872 T13082 T13081 arg1Of enlargement,marked
R10873 T13082 T13083 arg1Of enlargement,of
R10874 T13082 T13093 arg1Of enlargement,were
R10875 T13082 T13094 arg2Of enlargement,incubated
R10876 T13085 T13083 arg2Of spleen,of
R10877 T13085 T13084 arg1Of spleen,the
R10878 T13085 T13086 arg1Of spleen,of
R10879 T13088 T13087 arg1Of mice.,cpdm
R10880 T13088 T13089 arg1Of mice.,(
R10881 T13090 T13089 arg2Of D,(
R10882 T13091 T13089 arg3Of ),(
R10883 T13092 T13086 arg2Of BMDC,of
R10884 T13092 T13088 arg1Of BMDC,mice.
R10885 T13094 T13093 arg2Of incubated,were
R10886 T13094 T13095 arg1Of incubated,in
R10887 T13097 T13098 arg1Of absence,or
R10888 T13098 T13095 arg2Of or,in
R10889 T13098 T13096 arg1Of or,the
R10890 T13098 T13100 arg1Of or,of
R10891 T13099 T13098 arg2Of presence,or
R10892 T13101 T13102 arg1Of 100,ng/ml
R10893 T13103 T13100 arg2Of LPS,of
R10894 T13103 T13101 arg1Of LPS,100
R10895 T13103 T13104 arg1Of LPS,for
R10896 T13106 T13104 arg2Of hours,for
R10897 T13106 T13105 arg1Of hours,4
R10898 T13109 T13107 arg1Of level,The
R10899 T13109 T13108 arg1Of level,mRNA
R10900 T13109 T13110 arg1Of level,of
R10901 T13109 T13112 arg1Of level,was
R10902 T13109 T13113 arg2Of level,measured
R10903 T13109 T13117 arg1Of level,presented
R10904 T13111 T13110 arg2Of Sharpin,of
R10905 T13113 T13112 arg2Of measured,was
R10906 T13113 T13114 arg1Of measured,by
R10907 T13113 T13116 arg1Of measured,and
R10908 T13115 T13114 arg2Of qRT-PCR,by
R10909 T13117 T13116 arg2Of presented,and
R10910 T13117 T13119 arg1Of presented,to
R10911 T13119 T13118 arg1Of to,relative
R10912 T13122 T13119 arg2Of expression,to
R10913 T13122 T13120 arg1Of expression,the
R10914 T13122 T13121 arg1Of expression,mRNA
R10915 T13122 T13123 arg1Of expression,in
R10916 T13126 T13123 arg2Of BMDC,in
R10917 T13126 T13124 arg1Of BMDC,non-stimulated
R10918 T13126 T13125 arg1Of BMDC,WT
R10919 T13127 T13128 arg1Of Bars,represent
R10920 T13128 T13140 arg1Of represent,;
R10921 T13132 T13128 arg2Of s.d.,represent
R10922 T13132 T13129 arg1Of s.d.,the
R10923 T13132 T13130 arg1Of s.d.,mean
R10924 T13132 T13131 arg1Of s.d.,±
R10925 T13132 T13133 arg1Of s.d.,of
R10926 T13139 T13133 arg2Of 0.05,of
R10927 T13139 T13134 arg1Of 0.05,3
R10928 T13139 T13135 arg1Of 0.05,mice.
R10929 T13139 T13136 arg1Of 0.05,*
R10930 T13139 T13137 arg1Of 0.05,P
R10931 T13139 T13138 arg1Of 0.05,<
R10932 T13144 T13143 arg1Of 0.001.,<
R10933 T13146 T13145 arg2Of E,(
R10934 T13147 T13145 arg3Of ),(
R10935 T13148 T13141 arg1Of Fibroblast,**
R10936 T13148 T13142 arg1Of Fibroblast,P
R10937 T13148 T13144 arg1Of Fibroblast,0.001.
R10938 T13148 T13145 arg1Of Fibroblast,(
R10939 T13148 T13149 arg1Of Fibroblast,(
R10940 T13148 T13152 arg1Of Fibroblast,and
R10941 T13150 T13149 arg2Of NIH3T3,(
R10942 T13151 T13149 arg3Of ),(
R10943 T13152 T13154 arg1Of and,(
R10944 T13153 T13152 arg2Of macrophages,and
R10945 T13155 T13154 arg2Of RAW264.7,(
R10946 T13156 T13154 arg3Of ),(
R10947 T13157 T13148 arg1Of cells,Fibroblast
R10948 T13157 T13153 arg1Of cells,macrophages
R10949 T13157 T13158 arg1Of cells,were
R10950 T13157 T13159 arg2Of cells,transfected
R10951 T13159 T13140 arg2Of transfected,;
R10952 T13159 T13158 arg2Of transfected,were
R10953 T13159 T13160 arg1Of transfected,with
R10954 T13164 T13160 arg2Of pFLAG-SHARPIN,with
R10955 T13164 T13161 arg1Of pFLAG-SHARPIN,the
R10956 T13164 T13162 arg1Of pFLAG-SHARPIN,expression
R10957 T13164 T13163 arg1Of pFLAG-SHARPIN,plasmid
R10958 T13167 T13165 arg2Of hours,After
R10959 T13167 T13166 arg1Of hours,48
R10960 T13169 T13170 arg1Of cells,were
R10961 T13169 T13171 arg2Of cells,fixed
R10962 T13169 T13173 arg2Of cells,probed
R10963 T13171 T13172 arg1Of fixed,and
R10964 T13172 T13165 arg1Of and,After
R10965 T13172 T13168 arg1Of and,","
R10966 T13172 T13170 arg2Of and,were
R10967 T13173 T13172 arg2Of probed,and
R10968 T13173 T13174 arg1Of probed,with
R10969 T13175 T13176 arg1Of anti-FLAG,and
R10970 T13177 T13176 arg2Of FITC-conjugated,and
R10971 T13179 T13174 arg2Of antibody,with
R10972 T13179 T13175 arg1Of antibody,anti-FLAG
R10973 T13179 T13177 arg1Of antibody,FITC-conjugated
R10974 T13179 T13178 arg1Of antibody,secondary
R10975 T13180 T13181 arg1Of Nuclei,were
R10976 T13180 T13182 arg2Of Nuclei,stained
R10977 T13182 T13181 arg2Of stained,were
R10978 T13182 T13183 arg1Of stained,with
R10979 T13184 T13183 arg2Of DAPI,with
R10980 T13189 T13185 arg2Of lines,In
R10981 T13189 T13186 arg1Of lines,both
R10982 T13189 T13187 arg2Of lines,transfected
R10983 T13189 T13188 arg1Of lines,cell
R10984 T13191 T13192 arg1Of FLAG-SHARPIN,was
R10985 T13191 T13193 arg2Of FLAG-SHARPIN,found
R10986 T13191 T13195 arg1Of FLAG-SHARPIN,be
R10987 T13191 T13196 arg1Of FLAG-SHARPIN,cytoplasm-localized
R10988 T13193 T13185 arg1Of found,In
R10989 T13193 T13190 arg1Of found,","
R10990 T13193 T13192 arg2Of found,was
R10991 T13195 T13193 arg3Of be,found
R10992 T13195 T13194 arg1Of be,to
R10993 T13196 T13195 arg2Of cytoplasm-localized,be

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T2686 1013-1022 Anaphor denotes its level
T2687 960-967 Antecedent denotes present
R2262 T2686 T2687 boundBy its level,present

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T2226 0-16 NN denotes Characterization
T2227 17-19 IN denotes of
T2228 20-27 NNP denotes Sharpin
T2229 29-38 NNP denotes Orthologs
T2230 39-41 IN denotes of
T2231 42-49 NNP denotes SHARPIN
T2232 50-57 NN denotes protein
T2233 58-61 VBP denotes are
T2234 62-67 VBN denotes found
T2235 68-70 IN denotes in
T2236 71-78 JJ denotes various
T2237 79-86 NNS denotes species
T2238 86-87 , denotes ,
T2239 88-97 VBG denotes including
T2240 98-103 JJ denotes human
T2241 103-104 , denotes ,
T2242 105-110 NN denotes mouse
T2243 111-114 CC denotes and
T2244 115-118 NN denotes rat
T2245 118-119 . denotes .
T2246 120-125 NN denotes Motif
T2247 126-136 NN denotes prediction
T2248 137-148 NN denotes programming
T2249 148-149 , denotes ,
T2250 150-155 VBG denotes using
T2251 156-161 NNP denotes COILS
T2252 162-163 NNP denotes [
T2253 163-165 CD denotes 11
T2254 165-166 NNP denotes ]
T2255 167-170 CC denotes and
T2256 171-180 NNP denotes MotifScan
T2257 181-182 NNP denotes [
T2258 182-184 CD denotes 12
T2259 184-185 NNP denotes ]
T2260 185-186 , denotes ,
T2261 187-195 VBZ denotes suggests
T2262 196-200 IN denotes that
T2263 201-208 NNP denotes SHARPIN
T2264 209-217 VBZ denotes contains
T2265 218-219 DT denotes a
T2266 220-231 NN denotes coiled-coil
T2267 232-233 -LRB- denotes (
T2268 233-235 NNP denotes CC
T2269 235-236 -RRB- denotes )
T2270 237-243 NN denotes domain
T2271 243-244 , denotes ,
T2272 245-246 DT denotes a
T2273 247-261 JJ denotes ubiquitin-like
T2274 262-263 -LRB- denotes (
T2275 263-266 NNP denotes UBL
T2276 266-267 -RRB- denotes )
T2277 268-274 NN denotes domain
T2278 274-275 , denotes ,
T2279 276-279 CC denotes and
T2280 280-281 DT denotes a
T2281 282-293 NN denotes zinc-finger
T2282 294-305 NN denotes Ran-binding
T2283 306-313 NN denotes protein
T2284 314-315 CD denotes 2
T2285 316-317 -LRB- denotes (
T2286 317-322 NNP denotes ZFRBP
T2287 322-323 -RRB- denotes )
T2288 324-330 NN denotes domain
T2289 330-331 . denotes .
T2290 332-337 DT denotes These
T2291 338-348 JJ denotes functional
T2292 349-355 NNS denotes motifs
T2293 356-366 VBP denotes constitute
T2294 367-374 JJ denotes similar
T2295 375-381 NN denotes domain
T2296 382-390 NNS denotes profiles
T2297 391-395 WDT denotes that
T2298 396-399 VBP denotes are
T2299 400-407 JJ denotes present
T2300 408-410 IN denotes in
T2301 411-414 DT denotes the
T2302 415-422 NNP denotes SHARPIN
T2303 423-430 NN denotes protein
T2304 431-433 IN denotes of
T2305 434-437 DT denotes all
T2306 438-443 CD denotes three
T2307 444-451 NNS denotes origins
T2308 452-453 -LRB- denotes (
T2309 453-457 NNP denotes Fig.
T2310 458-460 NNP denotes 1A
T2311 460-461 -RRB- denotes )
T2312 461-462 , denotes ,
T2313 463-473 VBG denotes suggesting
T2314 474-478 IN denotes that
T2315 479-486 NNP denotes SHARPIN
T2316 487-493 VBZ denotes exerts
T2317 494-500 RB denotes highly
T2318 501-510 VBN denotes conserved
T2319 511-520 NNS denotes functions
T2320 521-527 IN denotes across
T2321 528-535 NNS denotes species
T2322 535-536 . denotes .
T2323 537-548 JJ denotes Spontaneous
T2324 549-558 NNS denotes mutations
T2325 559-561 IN denotes in
T2326 562-565 DT denotes the
T2327 566-571 NN denotes mouse
T2328 572-579 NNP denotes Sharpin
T2329 580-584 NN denotes gene
T2330 585-592 NNS denotes results
T2331 593-595 IN denotes in
T2332 596-597 DT denotes a
T2333 598-605 JJ denotes complex
T2334 606-618 JJ denotes inflammatory
T2335 619-628 NN denotes phenotype
T2336 629-642 VBN denotes characterized
T2337 643-645 IN denotes by
T2338 646-652 JJ denotes severe
T2339 653-663 NNS denotes dermatitis
T2340 664-665 -LRB- denotes (
T2341 665-669 NNP denotes Fig.
T2342 670-672 NNP denotes 1B
T2343 672-673 -RRB- denotes )
T2344 673-674 , denotes ,
T2345 675-683 JJ denotes systemic
T2346 684-696 NN denotes inflammation
T2347 697-700 CC denotes and
T2348 701-703 DT denotes an
T2349 704-712 JJ denotes enlarged
T2350 713-719 NN denotes spleen
T2351 720-721 -LRB- denotes (
T2352 721-725 NNP denotes Fig.
T2353 726-728 NNP denotes 1C
T2354 728-729 -RRB- denotes )
T2355 730-736 VBN denotes caused
T2356 737-739 IN denotes by
T2357 740-754 JJ denotes extramedullary
T2358 755-768 NN denotes hematopoiesis
T2359 769-770 NN denotes [
T2360 770-771 CD denotes 3
T2361 771-772 NNP denotes ]
T2362 772-773 . denotes .
T2363 774-777 DT denotes The
T2364 778-788 JJ denotes endogenous
T2365 789-799 NN denotes expression
T2366 800-802 IN denotes of
T2367 803-810 NNP denotes Sharpin
T2368 811-815 NNP denotes mRNA
T2369 816-818 IN denotes in
T2370 819-823 NNP denotes BMDC
T2371 824-827 VBD denotes was
T2372 828-838 VBN denotes determined
T2373 839-841 IN denotes by
T2374 842-854 JJ denotes quantitative
T2375 855-859 JJ denotes real
T2376 860-868 NN denotes time-PCR
T2377 869-870 -LRB- denotes (
T2378 870-877 NNP denotes qRT-PCR
T2379 877-878 -RRB- denotes )
T2380 879-888 JJ denotes following
T2381 889-896 NN denotes culture
T2382 897-899 IN denotes in
T2383 900-906 NN denotes medium
T2384 907-911 RB denotes only
T2385 912-914 CC denotes or
T2386 915-920 RB denotes after
T2387 921-932 NN denotes stimulation
T2388 933-937 IN denotes with
T2389 938-941 NNP denotes LPS
T2390 941-942 . denotes .
T2391 943-950 NNP denotes Sharpin
T2392 951-955 NNP denotes mRNA
T2393 956-959 VBD denotes was
T2394 960-967 JJ denotes present
T2395 968-970 IN denotes in
T2396 971-975 NNP denotes BMDC
T2397 976-985 VBD denotes generated
T2398 986-990 IN denotes from
T2399 991-993 NNP denotes WT
T2400 994-998 NNS denotes mice
T2401 999-1000 -LRB- denotes (
T2402 1000-1004 NNP denotes Fig.
T2403 1005-1007 NNP denotes 1D
T2404 1007-1008 -RRB- denotes )
T2405 1009-1012 CC denotes and
T2406 1013-1016 PRP$ denotes its
T2407 1017-1022 NN denotes level
T2408 1023-1026 VBD denotes was
T2409 1027-1035 RB denotes modestly
T2410 1036-1045 VBN denotes decreased
T2411 1046-1048 IN denotes by
T2412 1049-1052 NNP denotes LPS
T2413 1053-1064 NN denotes stimulation
T2414 1064-1065 . denotes .
T2415 1066-1071 EX denotes There
T2416 1072-1075 VBD denotes was
T2417 1076-1077 DT denotes a
T2418 1078-1089 JJ denotes significant
T2419 1090-1099 NN denotes reduction
T2420 1100-1102 IN denotes of
T2421 1103-1110 NNP denotes Sharpin
T2422 1111-1115 NNP denotes mRNA
T2423 1116-1117 -LRB- denotes (
T2424 1117-1118 CD denotes 6
T2425 1119-1125 JJ denotes 7-fold
T2426 1125-1126 -RRB- denotes )
T2427 1127-1129 IN denotes in
T2428 1130-1134 NNP denotes BMDC
T2429 1135-1144 VBD denotes generated
T2430 1145-1149 IN denotes from
T2431 1150-1154 NN denotes cpdm
T2432 1155-1159 NNS denotes mice
T2433 1159-1160 . denotes .
T2434 1161-1173 NNP denotes Transfection
T2435 1174-1176 IN denotes of
T2436 1177-1188 NNP denotes Flag-tagged
T2437 1189-1196 NNP denotes Sharpin
T2438 1197-1199 IN denotes in
T2439 1200-1211 NNS denotes fibroblasts
T2440 1212-1213 -LRB- denotes (
T2441 1213-1219 CD denotes NIH3T3
T2442 1219-1220 -RRB- denotes )
T2443 1221-1224 CC denotes and
T2444 1225-1236 NNS denotes macrophages
T2445 1237-1238 -LRB- denotes (
T2446 1238-1244 CD denotes RAW264
T2447 1244-1246 CD denotes .7
T2448 1246-1247 -RRB- denotes )
T2449 1248-1257 VBD denotes indicated
T2450 1258-1269 JJ denotes cytoplasmic
T2451 1270-1282 NN denotes localization
T2452 1283-1285 IN denotes of
T2453 1286-1289 DT denotes the
T2454 1290-1297 NNP denotes SHARPIN
T2455 1298-1305 NN denotes protein
T2456 1306-1307 -LRB- denotes (
T2457 1307-1311 NNP denotes Fig.
T2458 1312-1314 NNP denotes 1E
T2459 1314-1315 -RRB- denotes )
T2460 1315-1316 . denotes .
T12771 1361-1363 IN denotes In
T12772 1364-1368 NN denotes vivo
T12773 1369-1372 CC denotes and
T12774 1373-1375 IN denotes in
T12775 1376-1381 NN denotes vitro
T12776 1382-1390 NNS denotes features
T12777 1391-1393 IN denotes of
T12778 1394-1401 NNP denotes SHARPIN
T12779 1401-1402 . denotes .
T12780 1403-1404 -LRB- denotes (
T12781 1404-1405 NNP denotes A
T12782 1405-1406 -RRB- denotes )
T12783 1407-1412 NNP denotes COILS
T12784 1413-1416 CC denotes and
T12785 1417-1426 NNP denotes MotifScan
T12786 1427-1435 NNS denotes programs
T12787 1436-1440 VBD denotes were
T12788 1441-1445 VBN denotes used
T12789 1446-1448 TO denotes to
T12790 1449-1456 VB denotes predict
T12791 1457-1460 DT denotes the
T12792 1461-1469 NN denotes presence
T12793 1470-1472 IN denotes of
T12794 1473-1475 NNP denotes CC
T12795 1476-1477 -LRB- denotes (
T12796 1477-1488 NN denotes coiled-coil
T12797 1488-1489 -RRB- denotes )
T12798 1490-1496 NN denotes domain
T12799 1496-1497 , denotes ,
T12800 1498-1501 NNP denotes UBL
T12801 1502-1503 -LRB- denotes (
T12802 1503-1517 JJ denotes ubiquitin-like
T12803 1517-1518 -RRB- denotes )
T12804 1519-1525 NN denotes domain
T12805 1526-1529 CC denotes and
T12806 1530-1535 NNP denotes ZFRBP
T12807 1536-1537 -LRB- denotes (
T12808 1537-1548 NN denotes zinc-finger
T12809 1549-1560 NNP denotes Ran-Binding
T12810 1561-1568 NN denotes protein
T12811 1569-1570 CD denotes 2
T12812 1570-1571 -RRB- denotes )
T12813 1572-1578 NN denotes domain
T12814 1579-1584 WDT denotes which
T12815 1585-1589 VBP denotes form
T12816 1590-1597 JJ denotes similar
T12817 1598-1603 NN denotes motif
T12818 1604-1612 NNS denotes patterns
T12819 1613-1615 IN denotes in
T12820 1616-1619 DT denotes the
T12821 1620-1627 NNP denotes SHARPIN
T12822 1628-1635 NN denotes protein
T12823 1636-1638 IN denotes of
T12824 1639-1644 JJ denotes human
T12825 1644-1645 , denotes ,
T12826 1646-1651 NN denotes mouse
T12827 1652-1655 CC denotes and
T12828 1656-1659 NN denotes rat
T12829 1660-1667 NNS denotes origins
T12830 1667-1668 . denotes .
T12831 1669-1670 -LRB- denotes (
T12832 1670-1671 NNP denotes B
T12833 1671-1672 -RRB- denotes )
T12834 1673-1678 CD denotes Eight
T12835 1679-1687 JJ denotes week-old
T12836 1688-1695 NNS denotes females
T12837 1696-1698 IN denotes of
T12838 1699-1701 NNP denotes WT
T12839 1702-1705 CC denotes and
T12840 1706-1710 NN denotes cpdm
T12841 1711-1715 NNS denotes mice
T12842 1715-1716 . denotes .
T12843 1717-1720 DT denotes The
T12844 1721-1727 JJ denotes mutant
T12845 1728-1732 NNS denotes mice
T12846 1733-1734 -LRB- denotes (
T12847 1734-1739 IN denotes above
T12848 1739-1740 -RRB- denotes )
T12849 1741-1748 VB denotes develop
T12850 1749-1760 JJ denotes progressive
T12851 1761-1765 NN denotes skin
T12852 1766-1778 NN denotes inflammation
T12853 1779-1787 VBG denotes starting
T12854 1788-1790 IN denotes at
T12855 1791-1796 IN denotes about
T12856 1797-1801 CD denotes four
T12857 1802-1807 NNS denotes weeks
T12858 1807-1808 . denotes .
T12859 1809-1810 -LRB- denotes (
T12860 1810-1811 $ denotes C
T12861 1811-1812 -RRB- denotes )
T12862 1813-1827 JJ denotes Extramedullary
T12863 1828-1841 NN denotes hematopoiesis
T12864 1842-1848 VBZ denotes causes
T12865 1849-1855 JJ denotes marked
T12866 1856-1867 NN denotes enlargement
T12867 1868-1870 IN denotes of
T12868 1871-1874 DT denotes the
T12869 1875-1881 NN denotes spleen
T12870 1882-1884 IN denotes of
T12871 1885-1889 NN denotes cpdm
T12872 1890-1894 NNS denotes mice
T12873 1894-1895 . denotes .
T12874 1896-1897 -LRB- denotes (
T12875 1897-1898 NNP denotes D
T12876 1898-1899 -RRB- denotes )
T12877 1900-1904 NNP denotes BMDC
T12878 1905-1909 VBD denotes were
T12879 1910-1919 VBN denotes incubated
T12880 1920-1922 IN denotes in
T12881 1923-1926 DT denotes the
T12882 1927-1934 NN denotes absence
T12883 1935-1937 CC denotes or
T12884 1938-1946 NN denotes presence
T12885 1947-1949 IN denotes of
T12886 1950-1953 CD denotes 100
T12887 1954-1959 JJ denotes ng/ml
T12888 1960-1963 NNP denotes LPS
T12889 1964-1967 IN denotes for
T12890 1968-1969 CD denotes 4
T12891 1970-1975 NNS denotes hours
T12892 1975-1976 . denotes .
T12893 1977-1980 DT denotes The
T12894 1981-1985 NNP denotes mRNA
T12895 1986-1991 NN denotes level
T12896 1992-1994 IN denotes of
T12897 1995-2002 NNP denotes Sharpin
T12898 2003-2006 VBD denotes was
T12899 2007-2015 VBN denotes measured
T12900 2016-2018 IN denotes by
T12901 2019-2026 NNP denotes qRT-PCR
T12902 2027-2030 CC denotes and
T12903 2031-2040 VBN denotes presented
T12904 2041-2049 JJ denotes relative
T12905 2050-2052 TO denotes to
T12906 2053-2056 DT denotes the
T12907 2057-2061 NNP denotes mRNA
T12908 2062-2072 NN denotes expression
T12909 2073-2075 IN denotes in
T12910 2076-2090 JJ denotes non-stimulated
T12911 2091-2093 NNP denotes WT
T12912 2094-2098 NNP denotes BMDC
T12913 2098-2099 . denotes .
T12914 2100-2104 NNS denotes Bars
T12915 2105-2114 VBP denotes represent
T12916 2115-2118 DT denotes the
T12917 2119-2123 JJ denotes mean
T12918 2124-2125 NN denotes ±
T12919 2126-2130 NN denotes s.d.
T12920 2131-2133 IN denotes of
T12921 2134-2135 CD denotes 3
T12922 2136-2140 NNS denotes mice
T12923 2140-2141 . denotes .
T12924 2142-2143 SYM denotes *
T12925 2144-2145 NN denotes P
T12926 2145-2146 NN denotes <
T12927 2146-2150 CD denotes 0.05
T12928 2150-2151 : denotes ;
T12929 2152-2154 SYM denotes **
T12930 2155-2156 FW denotes P
T12931 2156-2157 FW denotes <
T12932 2157-2162 CD denotes 0.001
T12933 2162-2163 . denotes .
T12934 2164-2165 -LRB- denotes (
T12935 2165-2166 NNP denotes E
T12936 2166-2167 -RRB- denotes )
T12937 2168-2178 NNP denotes Fibroblast
T12938 2179-2180 -LRB- denotes (
T12939 2180-2186 NNP denotes NIH3T3
T12940 2186-2187 -RRB- denotes )
T12941 2188-2191 CC denotes and
T12942 2192-2203 NNS denotes macrophages
T12943 2204-2205 -LRB- denotes (
T12944 2205-2211 CD denotes RAW264
T12945 2211-2213 CD denotes .7
T12946 2213-2214 -RRB- denotes )
T12947 2215-2220 NNS denotes cells
T12948 2221-2225 VBD denotes were
T12949 2226-2237 VBN denotes transfected
T12950 2238-2242 IN denotes with
T12951 2243-2246 DT denotes the
T12952 2247-2257 NN denotes expression
T12953 2258-2265 VBD denotes plasmid
T12954 2266-2279 NNP denotes pFLAG-SHARPIN
T12955 2279-2280 . denotes .
T12956 2281-2286 IN denotes After
T12957 2287-2289 CD denotes 48
T12958 2290-2295 NNS denotes hours
T12959 2295-2296 , denotes ,
T12960 2297-2302 NNS denotes cells
T12961 2303-2307 VBD denotes were
T12962 2308-2313 VBN denotes fixed
T12963 2314-2317 CC denotes and
T12964 2318-2324 VBN denotes probed
T12965 2325-2329 IN denotes with
T12966 2330-2339 JJ denotes anti-FLAG
T12967 2340-2343 CC denotes and
T12968 2344-2359 JJ denotes FITC-conjugated
T12969 2360-2369 JJ denotes secondary
T12970 2370-2378 NN denotes antibody
T12971 2378-2379 . denotes .
T12972 2380-2386 NNP denotes Nuclei
T12973 2387-2391 VBD denotes were
T12974 2392-2399 VBN denotes stained
T12975 2400-2404 IN denotes with
T12976 2405-2409 NNP denotes DAPI
T12977 2409-2410 . denotes .
T12978 2411-2413 IN denotes In
T12979 2414-2418 DT denotes both
T12980 2419-2430 VBN denotes transfected
T12981 2431-2435 NN denotes cell
T12982 2436-2441 NNS denotes lines
T12983 2441-2442 , denotes ,
T12984 2443-2455 NNP denotes FLAG-SHARPIN
T12985 2456-2459 VBD denotes was
T12986 2460-2465 VBN denotes found
T12987 2466-2468 TO denotes to
T12988 2469-2471 VB denotes be
T12989 2472-2491 JJ denotes cytoplasm-localized
T12990 2491-2492 . denotes .
R1806 T2226 T2234 nsubjpass Characterization,found
R1807 T2227 T2226 prep of,Characterization
R1808 T2228 T2229 compound Sharpin,Orthologs
R1809 T2229 T2227 pobj Orthologs,of
R1810 T2230 T2229 prep of,Orthologs
R1811 T2231 T2232 compound SHARPIN,protein
R1812 T2232 T2230 pobj protein,of
R1813 T2233 T2234 auxpass are,found
R1814 T2234 T2234 ROOT found,found
R1815 T2235 T2234 prep in,found
R1816 T2236 T2237 amod various,species
R1817 T2237 T2235 pobj species,in
R1818 T2238 T2237 punct ",",species
R1819 T2239 T2237 prep including,species
R1820 T2240 T2239 pobj human,including
R1821 T2241 T2240 punct ",",human
R1822 T2242 T2240 conj mouse,human
R1823 T2243 T2242 cc and,mouse
R1824 T2244 T2242 conj rat,mouse
R1825 T2245 T2234 punct .,found
R1826 T2246 T2248 compound Motif,programming
R1827 T2247 T2248 compound prediction,programming
R1828 T2248 T2261 nsubj programming,suggests
R1829 T2249 T2248 punct ",",programming
R1830 T2250 T2248 acl using,programming
R1831 T2251 T2252 compound COILS,[
R1832 T2252 T2250 dobj [,using
R1833 T2253 T2254 nummod 11,]
R1834 T2254 T2252 conj ],[
R1835 T2255 T2254 cc and,]
R1836 T2256 T2257 compound MotifScan,[
R1837 T2257 T2254 conj [,]
R1838 T2258 T2259 nummod 12,]
R1839 T2259 T2254 conj ],]
R1840 T2260 T2261 punct ",",suggests
R1841 T2261 T2261 ROOT suggests,suggests
R1842 T2262 T2264 mark that,contains
R1843 T2263 T2264 nsubj SHARPIN,contains
R1844 T2264 T2261 ccomp contains,suggests
R1845 T2265 T2266 det a,coiled-coil
R1846 T2266 T2264 dobj coiled-coil,contains
R1847 T2267 T2268 punct (,CC
R1848 T2268 T2266 appos CC,coiled-coil
R1849 T2269 T2268 punct ),CC
R1850 T2270 T2266 conj domain,coiled-coil
R1851 T2271 T2266 punct ",",coiled-coil
R1852 T2272 T2273 det a,ubiquitin-like
R1853 T2273 T2266 appos ubiquitin-like,coiled-coil
R1854 T2274 T2275 punct (,UBL
R1855 T2275 T2273 appos UBL,ubiquitin-like
R1856 T2276 T2275 punct ),UBL
R1857 T2277 T2273 conj domain,ubiquitin-like
R1858 T2278 T2264 punct ",",contains
R1859 T2279 T2264 cc and,contains
R1860 T2280 T2283 det a,protein
R1861 T2281 T2283 nmod zinc-finger,protein
R1862 T2282 T2283 compound Ran-binding,protein
R1863 T2283 T2288 nmod protein,domain
R1864 T2284 T2283 nummod 2,protein
R1865 T2285 T2283 punct (,protein
R1866 T2286 T2283 appos ZFRBP,protein
R1867 T2287 T2283 punct ),protein
R1868 T2288 T2264 conj domain,contains
R1869 T2289 T2261 punct .,suggests
R1870 T2290 T2292 det These,motifs
R1871 T2291 T2292 amod functional,motifs
R1872 T2292 T2293 nsubj motifs,constitute
R1873 T2293 T2293 ROOT constitute,constitute
R1874 T2294 T2296 amod similar,profiles
R1875 T2295 T2296 compound domain,profiles
R1876 T2296 T2293 dobj profiles,constitute
R1877 T2297 T2298 nsubj that,are
R1878 T2298 T2296 relcl are,profiles
R1879 T2299 T2298 acomp present,are
R1880 T2300 T2299 prep in,present
R1881 T2301 T2303 det the,protein
R1882 T2302 T2303 compound SHARPIN,protein
R1883 T2303 T2300 pobj protein,in
R1884 T2304 T2303 prep of,protein
R1885 T2305 T2307 det all,origins
R1886 T2306 T2307 nummod three,origins
R1887 T2307 T2304 pobj origins,of
R1888 T2308 T2307 punct (,origins
R1889 T2309 T2310 compound Fig.,1A
R1890 T2310 T2307 appos 1A,origins
R1891 T2311 T2307 punct ),origins
R1892 T2312 T2296 punct ",",profiles
R1893 T2313 T2296 acl suggesting,profiles
R1894 T2314 T2318 mark that,conserved
R1895 T2315 T2318 nsubj SHARPIN,conserved
R1896 T2316 T2318 aux exerts,conserved
R1897 T2317 T2318 advmod highly,conserved
R1898 T2318 T2313 ccomp conserved,suggesting
R1899 T2319 T2318 dobj functions,conserved
R1900 T2320 T2319 prep across,functions
R1901 T2321 T2320 pobj species,across
R1902 T2322 T2293 punct .,constitute
R1903 T2323 T2324 amod Spontaneous,mutations
R1904 T2324 T2324 ROOT mutations,mutations
R1905 T2325 T2324 prep in,mutations
R1906 T2326 T2330 det the,results
R1907 T2327 T2329 compound mouse,gene
R1908 T2328 T2329 compound Sharpin,gene
R1909 T2329 T2330 compound gene,results
R1910 T2330 T2325 pobj results,in
R1911 T2331 T2324 prep in,mutations
R1912 T2332 T2335 det a,phenotype
R1913 T2333 T2335 amod complex,phenotype
R1914 T2334 T2335 amod inflammatory,phenotype
R1915 T2335 T2331 pobj phenotype,in
R1916 T2336 T2335 acl characterized,phenotype
R1917 T2337 T2336 agent by,characterized
R1918 T2338 T2339 amod severe,dermatitis
R1919 T2339 T2337 pobj dermatitis,by
R1920 T2340 T2342 punct (,1B
R1921 T2341 T2342 compound Fig.,1B
R1922 T2342 T2339 appos 1B,dermatitis
R1923 T2343 T2339 punct ),dermatitis
R1924 T2344 T2339 punct ",",dermatitis
R1925 T2345 T2346 amod systemic,inflammation
R1926 T2346 T2339 conj inflammation,dermatitis
R1927 T2347 T2346 cc and,inflammation
R1928 T2348 T2350 det an,spleen
R1929 T2349 T2350 amod enlarged,spleen
R1930 T2350 T2346 conj spleen,inflammation
R1931 T2351 T2350 punct (,spleen
R1932 T2352 T2353 compound Fig.,1C
R1933 T2353 T2350 appos 1C,spleen
R1934 T2354 T2350 punct ),spleen
R1935 T2355 T2346 acl caused,inflammation
R1936 T2356 T2355 agent by,caused
R1937 T2357 T2359 amod extramedullary,[
R1938 T2358 T2359 compound hematopoiesis,[
R1939 T2359 T2361 nmod [,]
R1940 T2360 T2359 nummod 3,[
R1941 T2361 T2356 pobj ],by
R1942 T2362 T2324 punct .,mutations
R1943 T2363 T2365 det The,expression
R1944 T2364 T2365 amod endogenous,expression
R1945 T2365 T2372 nsubjpass expression,determined
R1946 T2366 T2365 prep of,expression
R1947 T2367 T2368 compound Sharpin,mRNA
R1948 T2368 T2366 pobj mRNA,of
R1949 T2369 T2368 prep in,mRNA
R1950 T2370 T2369 pobj BMDC,in
R1951 T2371 T2372 auxpass was,determined
R1952 T2372 T2372 ROOT determined,determined
R1953 T2373 T2372 agent by,determined
R1954 T2374 T2376 amod quantitative,time-PCR
R1955 T2375 T2376 amod real,time-PCR
R1956 T2376 T2373 pobj time-PCR,by
R1957 T2377 T2376 punct (,time-PCR
R1958 T2378 T2376 appos qRT-PCR,time-PCR
R1959 T2379 T2376 punct ),time-PCR
R1960 T2380 T2372 prep following,determined
R1961 T2381 T2380 pobj culture,following
R1962 T2382 T2380 prep in,following
R1963 T2383 T2382 pobj medium,in
R1964 T2384 T2388 advmod only,with
R1965 T2385 T2384 cc or,only
R1966 T2386 T2384 conj after,only
R1967 T2387 T2386 pobj stimulation,after
R1968 T2388 T2380 prep with,following
R1969 T2389 T2388 pobj LPS,with
R1970 T2390 T2380 punct .,following
R1971 T2391 T2392 compound Sharpin,mRNA
R1972 T2392 T2393 nsubj mRNA,was
R1973 T2393 T2393 ROOT was,was
R1974 T2394 T2393 acomp present,was
R1975 T2395 T2394 prep in,present
R1976 T2396 T2395 pobj BMDC,in
R1977 T2397 T2393 conj generated,was
R1978 T2398 T2397 prep from,generated
R1979 T2399 T2400 compound WT,mice
R1980 T2400 T2398 pobj mice,from
R1981 T2401 T2403 punct (,1D
R1982 T2402 T2403 compound Fig.,1D
R1983 T2403 T2400 appos 1D,mice
R1984 T2404 T2403 punct ),1D
R1985 T2405 T2400 cc and,mice
R1986 T2406 T2407 poss its,level
R1987 T2407 T2410 nsubjpass level,decreased
R1988 T2408 T2410 auxpass was,decreased
R1989 T2409 T2410 advmod modestly,decreased
R1990 T2410 T2393 conj decreased,was
R1991 T2411 T2410 agent by,decreased
R1992 T2412 T2413 compound LPS,stimulation
R1993 T2413 T2411 pobj stimulation,by
R1994 T2414 T2410 punct .,decreased
R1995 T2415 T2416 expl There,was
R1996 T2416 T2416 ROOT was,was
R1997 T2417 T2419 det a,reduction
R1998 T2418 T2419 amod significant,reduction
R1999 T2419 T2416 attr reduction,was
R2000 T2420 T2419 prep of,reduction
R2001 T2421 T2422 compound Sharpin,mRNA
R2002 T2422 T2420 pobj mRNA,of
R2003 T2423 T2422 punct (,mRNA
R2004 T2424 T2422 appos 6,mRNA
R2005 T2425 T2422 appos 7-fold,mRNA
R2006 T2426 T2425 punct ),7-fold
R2007 T2427 T2425 prep in,7-fold
R2008 T2428 T2427 pobj BMDC,in
R2009 T2429 T2419 acl generated,reduction
R2010 T2430 T2429 prep from,generated
R2011 T2431 T2432 amod cpdm,mice
R2012 T2432 T2430 pobj mice,from
R2013 T2433 T2416 punct .,was
R2014 T2434 T2449 nsubj Transfection,indicated
R2015 T2435 T2434 prep of,Transfection
R2016 T2436 T2437 compound Flag-tagged,Sharpin
R2017 T2437 T2435 pobj Sharpin,of
R2018 T2438 T2434 prep in,Transfection
R2019 T2439 T2438 pobj fibroblasts,in
R2020 T2440 T2439 punct (,fibroblasts
R2021 T2441 T2439 appos NIH3T3,fibroblasts
R2022 T2442 T2439 punct ),fibroblasts
R2023 T2443 T2434 cc and,Transfection
R2024 T2444 T2434 conj macrophages,Transfection
R2025 T2445 T2444 punct (,macrophages
R2026 T2446 T2447 nummod RAW264,.7
R2027 T2447 T2444 appos .7,macrophages
R2028 T2448 T2444 punct ),macrophages
R2029 T2449 T2449 ROOT indicated,indicated
R2030 T2450 T2451 amod cytoplasmic,localization
R2031 T2451 T2449 dobj localization,indicated
R2032 T2452 T2451 prep of,localization
R2033 T2453 T2455 det the,protein
R2034 T2454 T2455 compound SHARPIN,protein
R2035 T2455 T2452 pobj protein,of
R2036 T2456 T2455 punct (,protein
R2037 T2457 T2458 compound Fig.,1E
R2038 T2458 T2455 appos 1E,protein
R2039 T2459 T2449 punct ),indicated
R2040 T2460 T2449 punct .,indicated
R10558 T12771 T12771 ROOT In,In
R10559 T12772 T12771 pobj vivo,In
R10560 T12773 T12771 cc and,In
R10561 T12774 T12771 conj in,In
R10562 T12775 T12776 amod vitro,features
R10563 T12776 T12774 pobj features,in
R10564 T12777 T12776 prep of,features
R10565 T12778 T12777 pobj SHARPIN,of
R10566 T12779 T12771 punct .,In
R10567 T12780 T12788 punct (,used
R10568 T12781 T12786 nmod A,programs
R10569 T12782 T12781 punct ),A
R10570 T12783 T12786 nmod COILS,programs
R10571 T12784 T12783 cc and,COILS
R10572 T12785 T12783 conj MotifScan,COILS
R10573 T12786 T12788 nsubjpass programs,used
R10574 T12787 T12788 auxpass were,used
R10575 T12788 T12788 ROOT used,used
R10576 T12789 T12790 aux to,predict
R10577 T12790 T12788 xcomp predict,used
R10578 T12791 T12792 det the,presence
R10579 T12792 T12790 dobj presence,predict
R10580 T12793 T12792 prep of,presence
R10581 T12794 T12793 pobj CC,of
R10582 T12795 T12794 punct (,CC
R10583 T12796 T12798 nmod coiled-coil,domain
R10584 T12797 T12798 punct ),domain
R10585 T12798 T12794 appos domain,CC
R10586 T12799 T12794 punct ",",CC
R10587 T12800 T12794 conj UBL,CC
R10588 T12801 T12802 punct (,ubiquitin-like
R10589 T12802 T12800 appos ubiquitin-like,UBL
R10590 T12803 T12802 punct ),ubiquitin-like
R10591 T12804 T12793 pobj domain,of
R10592 T12805 T12804 cc and,domain
R10593 T12806 T12813 compound ZFRBP,domain
R10594 T12807 T12810 punct (,protein
R10595 T12808 T12809 compound zinc-finger,Ran-Binding
R10596 T12809 T12810 compound Ran-Binding,protein
R10597 T12810 T12806 appos protein,ZFRBP
R10598 T12811 T12810 nummod 2,protein
R10599 T12812 T12810 punct ),protein
R10600 T12813 T12792 appos domain,presence
R10601 T12814 T12815 nsubj which,form
R10602 T12815 T12813 relcl form,domain
R10603 T12816 T12818 amod similar,patterns
R10604 T12817 T12818 compound motif,patterns
R10605 T12818 T12815 dobj patterns,form
R10606 T12819 T12818 prep in,patterns
R10607 T12820 T12822 det the,protein
R10608 T12821 T12822 compound SHARPIN,protein
R10609 T12822 T12819 pobj protein,in
R10610 T12823 T12822 prep of,protein
R10611 T12824 T12826 amod human,mouse
R10612 T12825 T12824 punct ",",human
R10613 T12826 T12823 pobj mouse,of
R10614 T12827 T12826 cc and,mouse
R10615 T12828 T12829 compound rat,origins
R10616 T12829 T12826 conj origins,mouse
R10617 T12830 T12788 punct .,used
R10618 T12831 T12832 punct (,B
R10619 T12832 T12832 ROOT B,B
R10620 T12833 T12832 punct ),B
R10621 T12834 T12836 nummod Eight,females
R10622 T12835 T12836 amod week-old,females
R10623 T12836 T12836 ROOT females,females
R10624 T12837 T12836 prep of,females
R10625 T12838 T12841 nmod WT,mice
R10626 T12839 T12838 cc and,WT
R10627 T12840 T12841 compound cpdm,mice
R10628 T12841 T12837 pobj mice,of
R10629 T12842 T12836 punct .,females
R10630 T12843 T12845 det The,mice
R10631 T12844 T12845 amod mutant,mice
R10632 T12845 T12849 nsubj mice,develop
R10633 T12846 T12847 punct (,above
R10634 T12847 T12845 advmod above,mice
R10635 T12848 T12847 punct ),above
R10636 T12849 T12849 ROOT develop,develop
R10637 T12850 T12852 amod progressive,inflammation
R10638 T12851 T12852 compound skin,inflammation
R10639 T12852 T12849 dobj inflammation,develop
R10640 T12853 T12849 advcl starting,develop
R10641 T12854 T12853 prep at,starting
R10642 T12855 T12856 advmod about,four
R10643 T12856 T12857 nummod four,weeks
R10644 T12857 T12854 pobj weeks,at
R10645 T12858 T12849 punct .,develop
R10646 T12859 T12860 punct (,C
R10647 T12860 T12860 ROOT C,C
R10648 T12861 T12860 punct ),C
R10649 T12862 T12863 amod Extramedullary,hematopoiesis
R10650 T12863 T12864 nsubj hematopoiesis,causes
R10651 T12864 T12864 ROOT causes,causes
R10652 T12865 T12866 amod marked,enlargement
R10653 T12866 T12864 dobj enlargement,causes
R10654 T12867 T12866 prep of,enlargement
R10655 T12868 T12869 det the,spleen
R10656 T12869 T12867 pobj spleen,of
R10657 T12870 T12869 prep of,spleen
R10658 T12871 T12872 compound cpdm,mice
R10659 T12872 T12870 pobj mice,of
R10660 T12873 T12864 punct .,causes
R10661 T12874 T12877 punct (,BMDC
R10662 T12875 T12877 nmod D,BMDC
R10663 T12876 T12877 punct ),BMDC
R10664 T12877 T12879 nsubjpass BMDC,incubated
R10665 T12878 T12879 auxpass were,incubated
R10666 T12879 T12879 ROOT incubated,incubated
R10667 T12880 T12879 prep in,incubated
R10668 T12881 T12882 det the,absence
R10669 T12882 T12880 pobj absence,in
R10670 T12883 T12882 cc or,absence
R10671 T12884 T12882 conj presence,absence
R10672 T12885 T12882 prep of,absence
R10673 T12886 T12888 nummod 100,LPS
R10674 T12887 T12888 compound ng/ml,LPS
R10675 T12888 T12885 pobj LPS,of
R10676 T12889 T12879 prep for,incubated
R10677 T12890 T12891 nummod 4,hours
R10678 T12891 T12889 pobj hours,for
R10679 T12892 T12879 punct .,incubated
R10680 T12893 T12895 det The,level
R10681 T12894 T12895 compound mRNA,level
R10682 T12895 T12899 nsubjpass level,measured
R10683 T12896 T12895 prep of,level
R10684 T12897 T12896 pobj Sharpin,of
R10685 T12898 T12899 auxpass was,measured
R10686 T12899 T12899 ROOT measured,measured
R10687 T12900 T12899 agent by,measured
R10688 T12901 T12900 pobj qRT-PCR,by
R10689 T12902 T12899 cc and,measured
R10690 T12903 T12899 conj presented,measured
R10691 T12904 T12903 advmod relative,presented
R10692 T12905 T12904 prep to,relative
R10693 T12906 T12908 det the,expression
R10694 T12907 T12908 compound mRNA,expression
R10695 T12908 T12905 pobj expression,to
R10696 T12909 T12908 prep in,expression
R10697 T12910 T12912 compound non-stimulated,BMDC
R10698 T12911 T12912 compound WT,BMDC
R10699 T12912 T12909 pobj BMDC,in
R10700 T12913 T12899 punct .,measured
R10701 T12914 T12915 nsubj Bars,represent
R10702 T12915 T12915 ROOT represent,represent
R10703 T12916 T12919 det the,s.d.
R10704 T12917 T12919 amod mean,s.d.
R10705 T12918 T12919 compound ±,s.d.
R10706 T12919 T12915 dobj s.d.,represent
R10707 T12920 T12919 prep of,s.d.
R10708 T12921 T12922 nummod 3,mice
R10709 T12922 T12920 pobj mice,of
R10710 T12923 T12915 punct .,represent
R10711 T12924 T12930 punct *,P
R10712 T12925 T12927 compound P,0.05
R10713 T12926 T12927 compound <,0.05
R10714 T12927 T12924 npadvmod 0.05,*
R10715 T12928 T12930 punct ;,P
R10716 T12929 T12930 punct **,P
R10717 T12930 T12930 ROOT P,P
R10718 T12931 T12930 prep <,P
R10719 T12932 T12931 pobj 0.001,<
R10720 T12933 T12930 punct .,P
R10721 T12934 T12937 punct (,Fibroblast
R10722 T12935 T12937 nmod E,Fibroblast
R10723 T12936 T12937 punct ),Fibroblast
R10724 T12937 T12947 nmod Fibroblast,cells
R10725 T12938 T12939 punct (,NIH3T3
R10726 T12939 T12937 appos NIH3T3,Fibroblast
R10727 T12940 T12939 punct ),NIH3T3
R10728 T12941 T12937 cc and,Fibroblast
R10729 T12942 T12937 conj macrophages,Fibroblast
R10730 T12943 T12942 punct (,macrophages
R10731 T12944 T12945 nummod RAW264,.7
R10732 T12945 T12942 appos .7,macrophages
R10733 T12946 T12942 punct ),macrophages
R10734 T12947 T12949 nsubjpass cells,transfected
R10735 T12948 T12949 auxpass were,transfected
R10736 T12949 T12949 ROOT transfected,transfected
R10737 T12950 T12949 prep with,transfected
R10738 T12951 T12952 det the,expression
R10739 T12952 T12950 pobj expression,with
R10740 T12953 T12949 conj plasmid,transfected
R10741 T12954 T12953 nsubj pFLAG-SHARPIN,plasmid
R10742 T12955 T12949 punct .,transfected
R10743 T12956 T12962 prep After,fixed
R10744 T12957 T12958 nummod 48,hours
R10745 T12958 T12956 pobj hours,After
R10746 T12959 T12962 punct ",",fixed
R10747 T12960 T12962 nsubjpass cells,fixed
R10748 T12961 T12962 auxpass were,fixed
R10749 T12962 T12962 ROOT fixed,fixed
R10750 T12963 T12962 cc and,fixed
R10751 T12964 T12962 conj probed,fixed
R10752 T12965 T12964 prep with,probed
R10753 T12966 T12970 amod anti-FLAG,antibody
R10754 T12967 T12966 cc and,anti-FLAG
R10755 T12968 T12966 conj FITC-conjugated,anti-FLAG
R10756 T12969 T12970 amod secondary,antibody
R10757 T12970 T12965 pobj antibody,with
R10758 T12971 T12962 punct .,fixed
R10759 T12972 T12974 nsubjpass Nuclei,stained
R10760 T12973 T12974 auxpass were,stained
R10761 T12974 T12974 ROOT stained,stained
R10762 T12975 T12974 prep with,stained
R10763 T12976 T12975 pobj DAPI,with
R10764 T12977 T12974 punct .,stained
R10765 T12978 T12986 prep In,found
R10766 T12979 T12982 det both,lines
R10767 T12980 T12982 amod transfected,lines
R10768 T12981 T12982 compound cell,lines
R10769 T12982 T12978 pobj lines,In
R10770 T12983 T12986 punct ",",found
R10771 T12984 T12986 nsubjpass FLAG-SHARPIN,found
R10772 T12985 T12986 auxpass was,found
R10773 T12986 T12986 ROOT found,found
R10774 T12987 T12988 aux to,be
R10775 T12988 T12986 xcomp be,found
R10776 T12989 T12988 acomp cytoplasm-localized,be
R10777 T12990 T12986 punct .,found

UBERON-AE

Id Subject Object Predicate Lexical cue
T12754 1875-1881 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen
T2198 713-719 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen

GO-BP

Id Subject Object Predicate Lexical cue
T2708 684-696 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T2709 755-768 http://purl.obolibrary.org/obo/GO_0030097 denotes hematopoiesis
T2710 1270-1282 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T13211 1766-1778 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T13212 1828-1841 http://purl.obolibrary.org/obo/GO_0030097 denotes hematopoiesis
T13213 2482-2491 http://purl.obolibrary.org/obo/GO_0051179 denotes localized

GO-MF

Id Subject Object Predicate Lexical cue
T2712 247-256 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T2713 294-313 http://purl.obolibrary.org/obo/GO_0008536 denotes Ran-binding protein
T2714 298-305 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T2715 298-313 http://purl.obolibrary.org/obo/GO_0005515 denotes binding protein
T2716 298-315 http://purl.obolibrary.org/obo/GO_0051721 denotes binding protein 2
T13214 1503-1512 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T13215 2370-2378 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody

GO-CC

Id Subject Object Predicate Lexical cue
T13216 2215-2220 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13217 2297-2302 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T13218 2431-2435 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T13219 2370-2378 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T13220 2370-2378 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T13221 2472-2481 http://purl.obolibrary.org/obo/GO_0005737 denotes cytoplasm

sentences

Id Subject Object Predicate Lexical cue
T12763 1361-1402 Sentence denotes In vivo and in vitro features of SHARPIN.
T12764 1403-1716 Sentence denotes (A) COILS and MotifScan programs were used to predict the presence of CC (coiled-coil) domain, UBL (ubiquitin-like) domain and ZFRBP (zinc-finger Ran-Binding protein 2) domain which form similar motif patterns in the SHARPIN protein of human, mouse and rat origins. (B) Eight week-old females of WT and cpdm mice.
T12765 1717-1976 Sentence denotes The mutant mice (above) develop progressive skin inflammation starting at about four weeks. (C) Extramedullary hematopoiesis causes marked enlargement of the spleen of cpdm mice. (D) BMDC were incubated in the absence or presence of 100 ng/ml LPS for 4 hours.
T12766 1977-2099 Sentence denotes The mRNA level of Sharpin was measured by qRT-PCR and presented relative to the mRNA expression in non-stimulated WT BMDC.
T12767 2100-2280 Sentence denotes Bars represent the mean ± s.d. of 3 mice. * P<0.05; ** P<0.001. (E) Fibroblast (NIH3T3) and macrophages (RAW264.7) cells were transfected with the expression plasmid pFLAG-SHARPIN.
T12768 2281-2379 Sentence denotes After 48 hours, cells were fixed and probed with anti-FLAG and FITC-conjugated secondary antibody.
T12769 2380-2410 Sentence denotes Nuclei were stained with DAPI.
T12770 2411-2492 Sentence denotes In both transfected cell lines, FLAG-SHARPIN was found to be cytoplasm-localized.
T2217 0-27 Sentence denotes Characterization of Sharpin
T2218 29-119 Sentence denotes Orthologs of SHARPIN protein are found in various species, including human, mouse and rat.
T2219 120-331 Sentence denotes Motif prediction programming, using COILS [11] and MotifScan [12], suggests that SHARPIN contains a coiled-coil (CC) domain, a ubiquitin-like (UBL) domain, and a zinc-finger Ran-binding protein 2 (ZFRBP) domain.
T2220 332-536 Sentence denotes These functional motifs constitute similar domain profiles that are present in the SHARPIN protein of all three origins (Fig. 1A), suggesting that SHARPIN exerts highly conserved functions across species.
T2221 537-773 Sentence denotes Spontaneous mutations in the mouse Sharpin gene results in a complex inflammatory phenotype characterized by severe dermatitis (Fig. 1B), systemic inflammation and an enlarged spleen (Fig. 1C) caused by extramedullary hematopoiesis [3].
T2222 774-942 Sentence denotes The endogenous expression of Sharpin mRNA in BMDC was determined by quantitative real time-PCR (qRT-PCR) following culture in medium only or after stimulation with LPS.
T2223 943-1065 Sentence denotes Sharpin mRNA was present in BMDC generated from WT mice (Fig. 1D) and its level was modestly decreased by LPS stimulation.
T2224 1066-1160 Sentence denotes There was a significant reduction of Sharpin mRNA (6–7-fold) in BMDC generated from cpdm mice.
T2225 1161-1316 Sentence denotes Transfection of Flag-tagged Sharpin in fibroblasts (NIH3T3) and macrophages (RAW264.7) indicated cytoplasmic localization of the SHARPIN protein (Fig. 1E).
T32 0-27 Sentence denotes Characterization of Sharpin
T33 29-119 Sentence denotes Orthologs of SHARPIN protein are found in various species, including human, mouse and rat.
T34 120-331 Sentence denotes Motif prediction programming, using COILS [11] and MotifScan [12], suggests that SHARPIN contains a coiled-coil (CC) domain, a ubiquitin-like (UBL) domain, and a zinc-finger Ran-binding protein 2 (ZFRBP) domain.
T35 332-536 Sentence denotes These functional motifs constitute similar domain profiles that are present in the SHARPIN protein of all three origins (Fig. 1A), suggesting that SHARPIN exerts highly conserved functions across species.
T36 537-773 Sentence denotes Spontaneous mutations in the mouse Sharpin gene results in a complex inflammatory phenotype characterized by severe dermatitis (Fig. 1B), systemic inflammation and an enlarged spleen (Fig. 1C) caused by extramedullary hematopoiesis [3].
T37 774-942 Sentence denotes The endogenous expression of Sharpin mRNA in BMDC was determined by quantitative real time-PCR (qRT-PCR) following culture in medium only or after stimulation with LPS.
T38 943-1065 Sentence denotes Sharpin mRNA was present in BMDC generated from WT mice (Fig. 1D) and its level was modestly decreased by LPS stimulation.
T39 1066-1160 Sentence denotes There was a significant reduction of Sharpin mRNA (6–7-fold) in BMDC generated from cpdm mice.
T40 1161-1316 Sentence denotes Transfection of Flag-tagged Sharpin in fibroblasts (NIH3T3) and macrophages (RAW264.7) indicated cytoplasmic localization of the SHARPIN protein (Fig. 1E).
T41 1317-1402 Sentence denotes 10.1371/journal.pone.0031809.g001 Figure 1 In vivo and in vitro features of SHARPIN.
T42 1403-1716 Sentence denotes (A) COILS and MotifScan programs were used to predict the presence of CC (coiled-coil) domain, UBL (ubiquitin-like) domain and ZFRBP (zinc-finger Ran-Binding protein 2) domain which form similar motif patterns in the SHARPIN protein of human, mouse and rat origins. (B) Eight week-old females of WT and cpdm mice.
T43 1717-1976 Sentence denotes The mutant mice (above) develop progressive skin inflammation starting at about four weeks. (C) Extramedullary hematopoiesis causes marked enlargement of the spleen of cpdm mice. (D) BMDC were incubated in the absence or presence of 100 ng/ml LPS for 4 hours.
T44 1977-2099 Sentence denotes The mRNA level of Sharpin was measured by qRT-PCR and presented relative to the mRNA expression in non-stimulated WT BMDC.
T45 2100-2280 Sentence denotes Bars represent the mean ± s.d. of 3 mice. * P<0.05; ** P<0.001. (E) Fibroblast (NIH3T3) and macrophages (RAW264.7) cells were transfected with the expression plasmid pFLAG-SHARPIN.
T46 2281-2379 Sentence denotes After 48 hours, cells were fixed and probed with anti-FLAG and FITC-conjugated secondary antibody.
T47 2380-2410 Sentence denotes Nuclei were stained with DAPI.
T48 2411-2492 Sentence denotes In both transfected cell lines, FLAG-SHARPIN was found to be cytoplasm-localized.

ICD10

Id Subject Object Predicate Lexical cue
T2711 653-663 http://purl.bioontology.org/ontology/ICD10/L30.9 denotes dermatitis

events-check-again

Id Subject Object Predicate Lexical cue Speculation
T2753 20-27 Protein denotes Sharpin
T2754 42-49 Protein denotes SHARPIN
T2755 201-208 Protein denotes SHARPIN
T2756 415-422 Protein denotes SHARPIN
T2757 479-486 Protein denotes SHARPIN
T2758 549-558 Negative_regulation denotes mutations
T2759 572-579 Protein denotes Sharpin
T2760 789-799 Transcription denotes expression
T2761 803-810 Protein denotes Sharpin
T2762 943-950 Protein denotes Sharpin
T2763 960-967 Transcription denotes present
T2764 1036-1045 Negative_regulation denotes decreased
T2765 1090-1099 Negative_regulation denotes reduction
T2766 1103-1110 Protein denotes Sharpin
T2767 1189-1196 Protein denotes Sharpin
T2768 1258-1269 Entity denotes cytoplasmic
T2769 1270-1282 Localization denotes localization
T2770 1290-1297 Protein denotes SHARPIN
T13238 1394-1401 Protein denotes SHARPIN
T13239 1620-1627 Protein denotes SHARPIN
T13240 1981-1991 Transcription denotes mRNA level true
T13241 1995-2002 Protein denotes Sharpin
T13242 2272-2279 Protein denotes SHARPIN
T13243 2448-2455 Protein denotes SHARPIN
T13244 2472-2481 Entity denotes cytoplasm
T13245 2482-2491 Localization denotes localized
R2277 T2759 T2758 themeOf Sharpin,mutations
R2278 T2761 T2760 themeOf Sharpin,expression
R2279 T2762 T2763 themeOf Sharpin,present
R2280 T2763 T2764 themeOf present,decreased
R2281 T2766 T2765 themeOf Sharpin,reduction
R2282 T2768 T2769 locationOf cytoplasmic,localization
R2283 T2770 T2769 themeOf SHARPIN,localization
R11000 T13241 T13240 themeOf Sharpin,mRNA level
R11001 T13243 T13245 themeOf SHARPIN,localized
R11002 T13244 T13245 locationOf cytoplasm,localized

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T2771 42-57 Protein denotes SHARPIN protein
T2772 201-208 Protein denotes SHARPIN
T2773 247-256 Protein denotes ubiquitin
T2774 282-315 Protein denotes zinc-finger Ran-binding protein 2
T2775 317-322 Protein denotes ZFRBP
T2776 324-330 Entity denotes domain
T2777 415-430 Protein denotes SHARPIN protein
T2778 479-486 Protein denotes SHARPIN
T2779 400-407 Gene_expression denotes present
T2780 572-584 Protein denotes Sharpin gene
T2781 803-810 Protein denotes Sharpin
T2782 789-799 Transcription denotes expression
T2783 943-955 Protein denotes Sharpin mRNA
T2784 1036-1045 Negative_regulation denotes decreased
T2785 1103-1115 Protein denotes Sharpin mRNA
T2786 1090-1099 Negative_regulation denotes reduction
T2787 1189-1196 Protein denotes Sharpin
T2788 1290-1305 Protein denotes SHARPIN protein
T2789 1307-1314 Protein denotes Fig. 1E
T2790 1161-1173 Gene_expression denotes Transfection
T2791 1161-1173 Positive_regulation denotes Transfection
T2792 1258-1269 Entity denotes cytoplasmic
T2793 1270-1282 Localization denotes localization
T2794 1270-1282 Localization denotes localization
T13246 1394-1401 Protein denotes SHARPIN
T13247 1498-1501 Protein denotes UBL
T13248 1503-1512 Protein denotes ubiquitin
T13249 1530-1535 Protein denotes ZFRBP
T13250 1537-1570 Protein denotes zinc-finger Ran-Binding protein 2
T13251 1620-1635 Protein denotes SHARPIN protein
T13252 1995-2002 Protein denotes Sharpin
T13253 2091-2098 Protein denotes WT BMDC
T13254 2062-2072 Transcription denotes expression
T13255 2443-2447 Protein denotes FLAG
T13256 2448-2455 Protein denotes SHARPIN
R2284 T2772 T2776 partOf SHARPIN,domain
R2285 T2774 T2776 partOf zinc-finger Ran-binding protein 2,domain
R2286 T2775 T2776 partOf ZFRBP,domain
R2287 T2777 T2779 themeOf SHARPIN protein,present
R2288 T2781 T2782 themeOf Sharpin,expression
R2289 T2783 T2784 themeOf Sharpin mRNA,decreased
R2290 T2785 T2786 themeOf Sharpin mRNA,reduction
R2291 T2787 T2790 themeOf Sharpin,Transfection
R2292 T2788 T2793 themeOf SHARPIN protein,localization
R2293 T2789 T2794 themeOf Fig. 1E,localization
R2294 T2790 T2791 themeOf Transfection,Transfection
R2295 T2792 T2793 locationOf cytoplasmic,localization
R2296 T2792 T2794 locationOf cytoplasmic,localization
R11003 T13253 T13254 themeOf WT BMDC,expression

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Speculation
T2214 1258-1269 Entity denotes cytoplasmic
T2215 1270-1282 Localization denotes localization
T2216 1290-1297 Protein denotes SHARPIN
T12755 1394-1401 Protein denotes SHARPIN
T12756 1620-1627 Protein denotes SHARPIN
T12757 1981-1991 Transcription denotes mRNA level true
T12758 1995-2002 Protein denotes Sharpin
T12759 2272-2279 Protein denotes SHARPIN
T12760 2448-2455 Protein denotes SHARPIN
T12761 2472-2481 Entity denotes cytoplasm
T12762 2482-2491 Localization denotes localized
T2199 20-27 Protein denotes Sharpin
T2200 42-49 Protein denotes SHARPIN
T2201 201-208 Protein denotes SHARPIN
T2202 415-422 Protein denotes SHARPIN
T2203 479-486 Protein denotes SHARPIN
T2204 549-558 Negative_regulation denotes mutations
T2205 572-579 Protein denotes Sharpin
T2206 789-799 Transcription denotes expression
T2207 803-810 Protein denotes Sharpin
T2208 943-950 Protein denotes Sharpin
T2209 960-967 Transcription denotes present
T2210 1036-1045 Negative_regulation denotes decreased
T2211 1090-1099 Negative_regulation denotes reduction
T2212 1103-1110 Protein denotes Sharpin
T2213 1189-1196 Protein denotes Sharpin
R1799 T2205 T2204 themeOf Sharpin,mutations
R1800 T2207 T2206 themeOf Sharpin,expression
R1801 T2208 T2209 themeOf Sharpin,present
R1802 T2209 T2210 themeOf present,decreased
R1803 T2212 T2211 themeOf Sharpin,reduction
R1804 T2214 T2215 locationOf cytoplasmic,localization
R1805 T2216 T2215 themeOf SHARPIN,localization
R10555 T12758 T12757 themeOf Sharpin,mRNA level
R10556 T12760 T12762 themeOf SHARPIN,localized
R10557 T12761 T12762 locationOf cytoplasm,localized

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T2688 20-27 Q9H0F6 denotes Sharpin
T2689 42-49 Q9H0F6 denotes SHARPIN
T2690 201-208 Q9H0F6 denotes SHARPIN
T2691 415-422 Q9H0F6 denotes SHARPIN
T2692 479-486 Q9H0F6 denotes SHARPIN
T2693 572-579 Q9H0F6 denotes Sharpin
T2694 803-810 Q9H0F6 denotes Sharpin
T2695 943-950 Q9H0F6 denotes Sharpin
T2696 1103-1110 Q9H0F6 denotes Sharpin
T2697 1189-1196 Q9H0F6 denotes Sharpin
T2698 1290-1297 Q9H0F6 denotes SHARPIN
T13197 1394-1401 Q9H0F6 denotes SHARPIN
T13198 1620-1627 Q9H0F6 denotes SHARPIN
T13199 1995-2002 Q9H0F6 denotes Sharpin
T13200 2041-2049 Q04864 denotes relative
T13201 2272-2279 Q9H0F6 denotes SHARPIN
T13202 2448-2455 Q9H0F6 denotes SHARPIN

test2

Id Subject Object Predicate Lexical cue Speculation
T2184 20-27 Protein denotes Sharpin
T2185 42-49 Protein denotes SHARPIN
T2186 201-208 Protein denotes SHARPIN
T2187 415-422 Protein denotes SHARPIN
T2188 479-486 Protein denotes SHARPIN
T2189 572-579 Protein denotes Sharpin
T2190 789-799 Gene_expression denotes expression
T2191 803-810 Protein denotes Sharpin
T2192 943-950 Protein denotes Sharpin
T2193 1090-1099 Negative_regulation denotes reduction
T2194 1103-1110 Protein denotes Sharpin
T2195 1189-1196 Protein denotes Sharpin
T2196 1270-1282 Localization denotes localization
T2197 1290-1297 Protein denotes SHARPIN
T12745 1394-1401 Protein denotes SHARPIN true
T12746 1620-1627 Protein denotes SHARPIN
T12747 1981-1991 Transcription denotes mRNA level
T12748 1995-2002 Protein denotes Sharpin
T12749 2057-2072 Transcription denotes mRNA expression
T12750 2247-2257 Gene_expression denotes expression
T12751 2272-2279 Protein denotes SHARPIN
T12752 2448-2455 Protein denotes SHARPIN
T12753 2482-2491 Localization denotes localized
R1796 T2191 T2190 themeOf Sharpin,expression
R1797 T2194 T2193 themeOf Sharpin,reduction
R1798 T2197 T2196 themeOf SHARPIN,localization
R10552 T12748 T12749 themeOf Sharpin,mRNA expression
R10553 T12748 T12747 themeOf Sharpin,mRNA level
R10554 T12752 T12753 themeOf SHARPIN,localized