PMC:3279418 / 22161-22429
Annnotations
pmc-enju-pas
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T8405 | 0-5 | NN | denotes | NF-κB |
T8406 | 6-16 | NN | denotes | activation |
T8407 | 17-20 | VB | denotes | was |
T8408 | 21-32 | RB | denotes | selectively |
T8409 | 33-42 | VB | denotes | inhibited |
T8410 | 43-45 | IN | denotes | in |
T8411 | 46-49 | NN | denotes | LPS |
T8412 | 50-53 | CC | denotes | and |
T8413 | 54-58 | NN | denotes | poly |
T8414 | 59-60 | NN | denotes | I |
T8415 | 60-61 | SYM | denotes | : |
T8416 | 61-62 | NN | denotes | C |
T8417 | 63-73 | VB | denotes | stimulated |
T8418 | 74-78 | NN | denotes | cpdm |
T8419 | 79-83 | NN | denotes | BMDC |
T8420 | 84-92 | VB | denotes | compared |
T8421 | 93-95 | TO | denotes | to |
T8422 | 96-100 | JJ | denotes | wild |
T8423 | 101-105 | NN | denotes | type |
T8424 | 105-106 | -COMMA- | denotes | , |
T8425 | 107-112 | IN | denotes | while |
T8426 | 113-123 | NN | denotes | activation |
T8427 | 124-126 | IN | denotes | of |
T8428 | 127-136 | NN | denotes | TBK1/IRF3 |
T8429 | 136-137 | -COMMA- | denotes | , |
T8430 | 138-144 | NN | denotes | ERK1/2 |
T8431 | 144-145 | -COMMA- | denotes | , |
T8432 | 146-148 | CC | denotes | or |
T8433 | 149-152 | NN | denotes | p38 |
T8434 | 153-156 | VB | denotes | was |
T8435 | 157-160 | RB | denotes | not |
T8436 | 160-161 | -COMMA- | denotes | , |
T8437 | 162-172 | VB | denotes | indicating |
T8438 | 173-177 | IN | denotes | that |
T8439 | 178-187 | VB | denotes | disrupted |
T8440 | 188-193 | NN | denotes | NF-κB |
T8441 | 194-203 | NN | denotes | signaling |
T8442 | 204-206 | IN | denotes | in |
T8443 | 207-211 | NN | denotes | cpdm |
T8444 | 212-214 | NN | denotes | DC |
T8445 | 215-217 | VB | denotes | is |
T8446 | 218-229 | JJ | denotes | responsible |
T8447 | 230-233 | IN | denotes | for |
T8448 | 234-237 | DT | denotes | the |
T8449 | 238-247 | JJ | denotes | defective |
T8450 | 248-256 | NN | denotes | cytokine |
T8451 | 257-267 | NN | denotes | expression |
R6970 | T8416 | T8405 | arg1Of | C,NF-κB |
R6971 | T8416 | T8417 | arg1Of | C,stimulated |
R6973 | T8417 | T8420 | arg1Of | stimulated,compared |
R6975 | T8417 | T8424 | arg1Of | stimulated,"," |
R6976 | T8417 | T8425 | arg1Of | stimulated,while |
R6978 | T8419 | T8417 | arg2Of | BMDC,stimulated |
R6979 | T8419 | T8418 | arg1Of | BMDC,cpdm |
R6981 | T8421 | T8420 | arg2Of | to,compared |
R6984 | T8423 | T8421 | arg2Of | type,to |
R6985 | T8423 | T8422 | arg1Of | type,wild |
R6987 | T8426 | T8427 | arg1Of | activation,of |
R6988 | T8426 | T8434 | arg1Of | activation,was |
R6989 | T8426 | T8437 | arg1Of | activation,indicating |
R6991 | T8428 | T8429 | arg1Of | TBK1/IRF3,"," |
R6992 | T8429 | T8432 | arg1Of | ",",or |
R6993 | T8430 | T8429 | arg2Of | ERK1/2,"," |
R6995 | T8432 | T8427 | arg2Of | or,of |
R6996 | T8432 | T8431 | arg1Of | or,"," |
R6997 | T8433 | T8432 | arg2Of | p38,or |
R6998 | T8437 | T8425 | arg2Of | indicating,while |
R6999 | T8437 | T8434 | arg2Of | indicating,was |
R7000 | T8437 | T8435 | arg1Of | indicating,not |
R7001 | T8437 | T8436 | arg1Of | indicating,"," |
R7003 | T8441 | T8439 | arg2Of | signaling,disrupted |
R7004 | T8441 | T8440 | arg1Of | signaling,NF-κB |
R7005 | T8441 | T8442 | arg1Of | signaling,in |
R7006 | T8441 | T8445 | arg1Of | signaling,is |
R7007 | T8441 | T8446 | arg1Of | signaling,responsible |
R7009 | T8444 | T8442 | arg2Of | DC,in |
R7010 | T8444 | T8443 | arg1Of | DC,cpdm |
R7011 | T8445 | T8437 | arg2Of | is,indicating |
R7012 | T8445 | T8438 | arg1Of | is,that |
R7014 | T8446 | T8445 | arg2Of | responsible,is |
R7015 | T8446 | T8447 | arg1Of | responsible,for |
R7020 | T8451 | T8447 | arg2Of | expression,for |
R7021 | T8451 | T8448 | arg1Of | expression,the |
R7022 | T8451 | T8449 | arg1Of | expression,defective |
R7023 | T8451 | T8450 | arg1Of | expression,cytokine |
R7193 | T8405 | T8407 | modOf | NF-κB,was |
R7203 | T8405 | T8415 | arg1Of | NF-κB,: |
R7208 | T8406 | T8407 | arg1Of | activation,was |
R7211 | T8406 | T8409 | arg2Of | activation,inhibited |
R7212 | T8409 | T8407 | arg2Of | inhibited,was |
R7216 | T8409 | T8408 | arg1Of | inhibited,selectively |
R7217 | T8409 | T8410 | arg1Of | inhibited,in |
R7222 | T8411 | T8412 | arg1Of | LPS,and |
R7229 | T8412 | T8410 | arg2Of | and,in |
R7232 | T8414 | T8412 | arg2Of | I,and |
R7237 | T8414 | T8413 | arg1Of | I,poly |
bionlp-st-ge-2016-spacy-parsed
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T7284 | 0-5 | JJ | denotes | NF-κB |
T7285 | 6-16 | NN | denotes | activation |
T7286 | 17-20 | VBD | denotes | was |
T7287 | 21-32 | RB | denotes | selectively |
T7288 | 33-42 | VBN | denotes | inhibited |
T7289 | 43-45 | IN | denotes | in |
T7290 | 46-49 | NNP | denotes | LPS |
T7291 | 50-53 | CC | denotes | and |
T7292 | 54-58 | RB | denotes | poly |
T7293 | 59-60 | PRP | denotes | I |
T7294 | 60-61 | : | denotes | : |
T7295 | 61-62 | NNP | denotes | C |
T7296 | 63-73 | VBD | denotes | stimulated |
T7297 | 74-78 | NN | denotes | cpdm |
T7298 | 79-83 | NNP | denotes | BMDC |
T7299 | 84-92 | VBN | denotes | compared |
T7300 | 93-95 | TO | denotes | to |
T7301 | 96-100 | JJ | denotes | wild |
T7302 | 101-105 | NN | denotes | type |
T7303 | 105-106 | , | denotes | , |
T7304 | 107-112 | IN | denotes | while |
T7305 | 113-123 | NN | denotes | activation |
T7306 | 124-126 | IN | denotes | of |
T7307 | 127-136 | CD | denotes | TBK1/IRF3 |
T7308 | 136-137 | , | denotes | , |
T7309 | 138-144 | NNP | denotes | ERK1/2 |
T7310 | 144-145 | , | denotes | , |
T7311 | 146-148 | CC | denotes | or |
T7312 | 149-152 | CD | denotes | p38 |
T7313 | 153-156 | VBD | denotes | was |
T7314 | 157-160 | RB | denotes | not |
T7315 | 160-161 | , | denotes | , |
T7316 | 162-172 | VBG | denotes | indicating |
T7317 | 173-177 | IN | denotes | that |
T7318 | 178-187 | VBN | denotes | disrupted |
T7319 | 188-193 | NNP | denotes | NF-κB |
T7320 | 194-203 | VBG | denotes | signaling |
T7321 | 204-206 | IN | denotes | in |
T7322 | 207-211 | NN | denotes | cpdm |
T7323 | 212-214 | NNP | denotes | DC |
T7324 | 215-217 | VBZ | denotes | is |
T7325 | 218-229 | JJ | denotes | responsible |
T7326 | 230-233 | IN | denotes | for |
T7327 | 234-237 | DT | denotes | the |
T7328 | 238-247 | JJ | denotes | defective |
T7329 | 248-256 | NN | denotes | cytokine |
T7330 | 257-267 | NN | denotes | expression |
T7331 | 267-268 | . | denotes | . |
R5890 | T7284 | T7285 | amod | NF-κB,activation |
R5891 | T7285 | T7288 | nsubjpass | activation,inhibited |
R5892 | T7286 | T7288 | auxpass | was,inhibited |
R5893 | T7287 | T7288 | advmod | selectively,inhibited |
R5894 | T7288 | T7288 | ROOT | inhibited,inhibited |
R5895 | T7289 | T7288 | prep | in,inhibited |
R5896 | T7290 | T7289 | pobj | LPS,in |
R5897 | T7291 | T7288 | cc | and,inhibited |
R5898 | T7292 | T7296 | advmod | poly,stimulated |
R5899 | T7293 | T7296 | dep | I,stimulated |
R5900 | T7294 | T7296 | punct | :,stimulated |
R5901 | T7295 | T7296 | npadvmod | C,stimulated |
R5902 | T7296 | T7288 | conj | stimulated,inhibited |
R5903 | T7297 | T7298 | compound | cpdm,BMDC |
R5904 | T7298 | T7296 | dobj | BMDC,stimulated |
R5905 | T7299 | T7296 | prep | compared,stimulated |
R5906 | T7300 | T7299 | prep | to,compared |
R5907 | T7301 | T7302 | amod | wild,type |
R5908 | T7302 | T7300 | pobj | type,to |
R5909 | T7303 | T7296 | punct | ",",stimulated |
R5910 | T7304 | T7313 | mark | while,was |
R5911 | T7305 | T7313 | nsubj | activation,was |
R5912 | T7306 | T7305 | prep | of,activation |
R5913 | T7307 | T7306 | pobj | TBK1/IRF3,of |
R5914 | T7308 | T7305 | punct | ",",activation |
R5915 | T7309 | T7305 | conj | ERK1/2,activation |
R5916 | T7310 | T7309 | punct | ",",ERK1/2 |
R5917 | T7311 | T7309 | cc | or,ERK1/2 |
R5918 | T7312 | T7309 | conj | p38,ERK1/2 |
R5919 | T7313 | T7296 | advcl | was,stimulated |
R5920 | T7314 | T7313 | neg | not,was |
R5921 | T7315 | T7296 | punct | ",",stimulated |
R5922 | T7316 | T7296 | advcl | indicating,stimulated |
R5923 | T7317 | T7318 | mark | that,disrupted |
R5924 | T7318 | T7316 | ccomp | disrupted,indicating |
R5925 | T7319 | T7320 | nsubj | NF-κB,signaling |
R5926 | T7320 | T7318 | ccomp | signaling,disrupted |
R5927 | T7321 | T7320 | prep | in,signaling |
R5928 | T7322 | T7323 | compound | cpdm,DC |
R5929 | T7323 | T7321 | pobj | DC,in |
R5930 | T7324 | T7320 | ccomp | is,signaling |
R5931 | T7325 | T7324 | acomp | responsible,is |
R5932 | T7326 | T7325 | prep | for,responsible |
R5933 | T7327 | T7330 | det | the,expression |
R5934 | T7328 | T7330 | amod | defective,expression |
R5935 | T7329 | T7330 | compound | cytokine,expression |
R5936 | T7330 | T7326 | pobj | expression,for |
R5937 | T7331 | T7296 | punct | .,stimulated |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T9130 | 194-203 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
T9160 | 138-142 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | ERK1 |
T9161 | 149-152 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | p38 |
T9163 | 0-16 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T9172 | 127-131 | http://purl.obolibrary.org/obo/GO_0008384 | denotes | TBK1 |
GO-MF
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T9191 | 138-142 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | ERK1 |
T9192 | 149-152 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | p38 |
T9193 | 127-131 | http://purl.obolibrary.org/obo/GO_0008384 | denotes | TBK1 |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T6782 | 0-268 | Sentence | denotes | NF-κB activation was selectively inhibited in LPS and poly I:C stimulated cpdm BMDC compared to wild type, while activation of TBK1/IRF3, ERK1/2, or p38 was not, indicating that disrupted NF-κB signaling in cpdm DC is responsible for the defective cytokine expression. |
T147 | 0-268 | Sentence | denotes | NF-κB activation was selectively inhibited in LPS and poly I:C stimulated cpdm BMDC compared to wild type, while activation of TBK1/IRF3, ERK1/2, or p38 was not, indicating that disrupted NF-κB signaling in cpdm DC is responsible for the defective cytokine expression. |
events-check-again
Id | Subject | Object | Predicate | Lexical cue | Negation |
---|---|---|---|---|---|
T9391 | 113-123 | Positive_regulation | denotes | activation | |
T9392 | 113-123 | Positive_regulation | denotes | activation | |
T9393 | 113-123 | Positive_regulation | denotes | activation | |
T9394 | 113-123 | Positive_regulation | denotes | activation | |
T9395 | 127-131 | Protein | denotes | TBK1 | |
T9396 | 132-136 | Protein | denotes | IRF3 | |
T9397 | 138-142 | Protein | denotes | ERK1 | |
T9398 | 143-144 | Protein | denotes | 2 | |
T9399 | 153-160 | Negative_regulation | denotes | was not | true |
T9400 | 153-160 | Negative_regulation | denotes | was not | true |
T9401 | 153-160 | Negative_regulation | denotes | was not | true |
T9402 | 153-160 | Negative_regulation | denotes | was not | true |
R7747 | T9391 | T9400 | themeOf | activation,was not | |
R7748 | T9392 | T9402 | themeOf | activation,was not | |
R7749 | T9393 | T9399 | themeOf | activation,was not | |
R7750 | T9394 | T9401 | themeOf | activation,was not | |
R7751 | T9395 | T9394 | themeOf | TBK1,activation | |
R7753 | T9396 | T9393 | themeOf | IRF3,activation | |
R7754 | T9397 | T9391 | themeOf | ERK1,activation | |
R7755 | T9398 | T9392 | themeOf | 2,activation |
bionlp-st-ge-2016-reference-tees
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T9481 | 0-5 | Protein | denotes | NF-κB |
T9482 | 127-131 | Protein | denotes | TBK1 |
T9483 | 132-136 | Protein | denotes | IRF3 |
T9484 | 138-142 | Protein | denotes | ERK1 |
T9485 | 149-152 | Protein | denotes | p38 |
T9486 | 188-193 | Protein | denotes | NF-κB |
T9487 | 6-16 | Positive_regulation | denotes | activation |
T9488 | 33-42 | Negative_regulation | denotes | inhibited |
T9489 | 113-123 | Positive_regulation | denotes | activation |
T9490 | 113-123 | Positive_regulation | denotes | activation |
T9491 | 113-123 | Positive_regulation | denotes | activation |
T9492 | 113-123 | Positive_regulation | denotes | activation |
R7814 | T9481 | T9487 | themeOf | NF-κB,activation |
R7815 | T9482 | T9489 | themeOf | TBK1,activation |
R7816 | T9483 | T9490 | themeOf | IRF3,activation |
R7817 | T9484 | T9491 | themeOf | ERK1,activation |
R7818 | T9485 | T9492 | themeOf | p38,activation |
R7819 | T9487 | T9488 | themeOf | activation,inhibited |
bionlp-st-ge-2016-reference
Id | Subject | Object | Predicate | Lexical cue | Negation |
---|---|---|---|---|---|
T6703 | 113-123 | Positive_regulation | denotes | activation | |
T6704 | 113-123 | Positive_regulation | denotes | activation | |
T6705 | 113-123 | Positive_regulation | denotes | activation | |
T6706 | 113-123 | Positive_regulation | denotes | activation | |
T6707 | 127-131 | Protein | denotes | TBK1 | |
T6708 | 132-136 | Protein | denotes | IRF3 | |
T6709 | 138-142 | Protein | denotes | ERK1 | |
T6710 | 143-144 | Protein | denotes | 2 | |
T6711 | 153-160 | Negative_regulation | denotes | was not | true |
T6712 | 153-160 | Negative_regulation | denotes | was not | true |
T6713 | 153-160 | Negative_regulation | denotes | was not | true |
T6714 | 153-160 | Negative_regulation | denotes | was not | true |
R5379 | T6703 | T6712 | themeOf | activation,was not | |
R5380 | T6704 | T6714 | themeOf | activation,was not | |
R5381 | T6705 | T6711 | themeOf | activation,was not | |
R5382 | T6706 | T6713 | themeOf | activation,was not | |
R5383 | T6707 | T6706 | themeOf | TBK1,activation | |
R5384 | T6708 | T6705 | themeOf | IRF3,activation | |
R5385 | T6709 | T6703 | themeOf | ERK1,activation | |
R5386 | T6710 | T6704 | themeOf | 2,activation |
bionlp-st-ge-2016-uniprot
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T9050 | 127-131 | Q9UHD2 | denotes | TBK1 |
T9051 | 132-136 | Q14653 | denotes | IRF3 |
T9052 | 138-142 | P27361 | denotes | ERK1 |
T9053 | 149-152 | Q16539 | denotes | p38 |
T9054 | 149-152 | P53778 | denotes | p38 |
T9055 | 149-152 | O15264 | denotes | p38 |
T9056 | 149-152 | Q15759 | denotes | p38 |