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PMC:3279418 / 19344-26127 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
22348129-19720113-89575693 1136-1138 19720113 denotes 32
22348129-21455173-89575694 1498-1499 21455173 denotes 7
22348129-21455181-89575695 1503-1504 21455181 denotes 8
22348129-7792947-89575696 1738-1740 7792947 denotes 33
22348129-21620685-89575697 1808-1810 21620685 denotes 34
22348129-19720113-89575698 1996-1998 19720113 denotes 32
22348129-17979840-89575699 2002-2004 17979840 denotes 35
22348129-16267105-89575700 2043-2045 16267105 denotes 36
22348129-16878026-89575701 2049-2051 16878026 denotes 37
22348129-11241277-89575702 2117-2118 11241277 denotes 5
22348129-11241277-89575703 2321-2322 11241277 denotes 5
22348129-8630732-89575704 2585-2587 8630732 denotes 38
22348129-8766560-89575705 2591-2593 8766560 denotes 39
22348129-8894351-89575706 2643-2645 8894351 denotes 40
22348129-7930584-89575707 2648-2650 7930584 denotes 42
22348129-20811394-89575708 3218-3220 20811394 denotes 43
22348129-19855404-89575709 3481-3483 19855404 denotes 44
22348129-11009421-89575710 3709-3711 11009421 denotes 45
22348129-18246070-89575711 3715-3717 18246070 denotes 46
22348129-12075355-89575712 3895-3897 12075355 denotes 47
22348129-17361131-89575713 3900-3902 17361131 denotes 50
22348129-11869686-89575714 4628-4630 11869686 denotes 51
22348129-17513725-89575715 4634-4636 17513725 denotes 52
22348129-21455173-89575716 4747-4748 21455173 denotes 7
22348129-21455180-89575717 4752-4753 21455180 denotes 9
22348129-15229469-89575718 5448-5450 15229469 denotes 53
22348129-19686699-89575719 5642-5644 19686699 denotes 18
22348129-21455173-89575720 5819-5820 21455173 denotes 7
T75014 1136-1138 19720113 denotes 32
T48730 1498-1499 21455173 denotes 7
T86456 1503-1504 21455181 denotes 8
T13816 1738-1740 7792947 denotes 33
T92727 1808-1810 21620685 denotes 34
T91786 1996-1998 19720113 denotes 32
T32556 2002-2004 17979840 denotes 35
T39324 2043-2045 16267105 denotes 36
T67123 2049-2051 16878026 denotes 37
T42257 2117-2118 11241277 denotes 5
T36921 2321-2322 11241277 denotes 5
T93315 2585-2587 8630732 denotes 38
T8547 2591-2593 8766560 denotes 39
T53614 2643-2645 8894351 denotes 40
T53448 2648-2650 7930584 denotes 42
T3770 3218-3220 20811394 denotes 43
T93400 3481-3483 19855404 denotes 44
T12295 3709-3711 11009421 denotes 45
T89481 3715-3717 18246070 denotes 46
T82809 3895-3897 12075355 denotes 47
T7028 3900-3902 17361131 denotes 50
T8190 4628-4630 11869686 denotes 51
T11191 4634-4636 17513725 denotes 52
T86732 4747-4748 21455173 denotes 7
T38809 4752-4753 21455180 denotes 9
T77167 5448-5450 15229469 denotes 53
T66479 5642-5644 19686699 denotes 18
T44614 5819-5820 21455173 denotes 7

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T7942 11-14 DT denotes The
T7943 15-22 JJ denotes present
T7944 23-29 NN denotes report
T7945 30-36 VB denotes showed
T7946 37-41 IN denotes that
T7947 42-46 JJ denotes null
T7948 47-56 NN denotes mutations
T7949 57-59 IN denotes of
T7950 60-63 DT denotes the
T7951 64-69 NN denotes mouse
T7952 70-77 NN denotes Sharpin
T7953 78-82 NN denotes gene
T7954 83-86 VB denotes did
T7955 87-90 RB denotes not
T7956 91-97 VB denotes affect
T7957 98-101 DT denotes the
T7958 102-114 JJ denotes steady-state
T7959 115-127 NN denotes distribution
T7960 128-130 IN denotes of
T7961 131-138 JJ denotes splenic
T7962 139-141 NN denotes DC
T7963 142-149 NN denotes subsets
T7964 150-153 CC denotes nor
T7965 154-157 DT denotes the
T7966 158-169 NN denotes development
T7967 170-173 CC denotes and
T7968 174-183 NN denotes phenotype
T7969 184-186 IN denotes of
T7970 187-191 NN denotes BMDC
T7971 193-200 RB denotes However
T7972 200-201 -COMMA- denotes ,
T7973 202-206 NN denotes loss
T7974 207-209 IN denotes of
T7975 210-217 NN denotes SHARPIN
T7976 218-231 RB denotes significantly
T7977 232-242 VB denotes diminished
T7978 243-246 DT denotes the
T7979 247-255 NN denotes capacity
T7980 256-258 IN denotes of
T7981 259-263 NN denotes BMDC
T7982 264-266 TO denotes to
T7983 267-274 VB denotes secrete
T7984 275-287 JJ denotes inflammatory
T7985 288-297 NN denotes cytokines
T7986 298-301 CC denotes and
T7987 302-308 JJ denotes nitric
T7988 309-314 NN denotes oxide
T7989 316-319 DT denotes The
T7990 320-330 VB denotes attenuated
T7991 331-339 NN denotes cytokine
T7992 340-350 NN denotes production
T7993 351-354 VB denotes was
T7994 355-358 RB denotes not
T7995 359-362 JJ denotes due
T7996 363-365 TO denotes to
T7997 366-369 DT denotes the
T7998 370-378 NN denotes presence
T7999 379-381 IN denotes of
T8000 382-399 JJ denotes anti-inflammatory
T8001 400-410 NN denotes inhibitors
T8002 410-411 -COMMA- denotes ,
T8003 412-415 CC denotes and
T8004 416-419 MD denotes can
T8005 420-422 VB denotes be
T8006 423-430 RB denotes largely
T8007 431-440 VB denotes explained
T8008 441-443 IN denotes by
T8009 444-453 JJ denotes selective
T8010 454-466 NN denotes inactivation
T8011 467-469 IN denotes of
T8012 470-475 NN denotes NF-κB
T8013 476-485 NN denotes signaling
T8014 487-497 VB denotes Stimulated
T8015 498-502 NN denotes cpdm
T8016 503-507 NN denotes BMDC
T8017 508-517 VB denotes exhibited
T8018 518-528 JJ denotes Th2-biased
T8019 529-530 NN denotes T
T8020 531-546 JJ denotes cell-polarizing
T8021 547-559 NN denotes capabilities
T8022 559-560 -COMMA- denotes ,
T8023 561-571 JJ denotes consistent
T8024 572-576 IN denotes with
T8025 577-580 DT denotes the
T8026 581-584 NN denotes Th2
T8027 585-602 JJ denotes cytokine-dominant
T8028 603-612 NN denotes phenotype
T8029 613-615 IN denotes in
T8030 616-620 NN denotes cpdm
T8031 621-625 NN denotes mice
T8032 627-635 RB denotes Together
T8033 635-636 -COMMA- denotes ,
T8034 637-642 DT denotes these
T8035 643-650 NN denotes results
T8036 651-659 VB denotes indicate
T8037 660-662 DT denotes an
T8038 663-676 JJ denotes indispensible
T8039 677-681 NN denotes role
T8040 682-684 IN denotes of
T8041 685-692 NN denotes SHARPIN
T8042 693-695 IN denotes in
T8043 696-706 VB denotes regulating
T8044 707-709 NN denotes DC
T8045 710-723 JJ denotes immunological
T8046 724-733 NN denotes functions
T8047 733-734 -COMMA- denotes ,
T8048 735-745 NN denotes disruption
T8049 746-748 IN denotes of
T8050 749-754 WDT denotes which
T8051 755-758 MD denotes may
T8052 759-769 VB denotes contribute
T8053 770-772 TO denotes to
T8054 773-776 DT denotes the
T8055 777-788 NN denotes development
T8056 789-791 IN denotes of
T8057 792-798 JJ denotes immune
T8058 799-807 NN denotes diseases
T8059 809-814 IN denotes Since
T8060 815-817 NN denotes WT
T8061 818-821 CC denotes and
T8062 822-826 NN denotes cpdm
T8063 827-831 NN denotes mice
T8064 832-835 VB denotes are
T8065 836-840 DT denotes both
T8066 841-849 JJ denotes specific
T8067 850-863 NN denotes pathogen-free
T8068 863-864 -COMMA- denotes ,
T8069 865-868 DT denotes the
T8070 869-875 NN denotes nature
T8071 876-878 IN denotes of
T8072 879-882 DT denotes the
T8073 883-890 NN denotes trigger
T8074 891-893 IN denotes of
T8075 894-897 DT denotes the
T8076 898-904 JJ denotes severe
T8077 905-917 NN denotes inflammation
T8078 918-920 IN denotes in
T8079 921-925 NN denotes cpdm
T8080 926-930 NN denotes mice
T8081 931-933 VB denotes is
T8082 934-937 RB denotes not
T8083 938-945 JJ denotes obvious
T8084 947-950 CD denotes One
T8085 951-955 JJ denotes such
T8086 956-966 VB denotes initiating
T8087 967-973 NN denotes factor
T8088 974-979 MD denotes could
T8089 980-982 VB denotes be
T8090 983-993 JJ denotes endogenous
T8091 994-1003 JJ denotes apoptotic
T8092 1004-1010 CC denotes and/or
T8093 1011-1019 JJ denotes necrotic
T8094 1020-1025 NN denotes cells
T8095 1026-1030 WDT denotes that
T8096 1031-1034 MD denotes can
T8097 1035-1042 VB denotes release
T8098 1043-1060 JJ denotes danger-associated
T8099 1061-1070 JJ denotes molecular
T8100 1071-1079 NN denotes patterns
T8101 1080-1081 -LRB- denotes (
T8102 1081-1086 NN denotes DAMPs
T8103 1086-1087 -RRB- denotes )
T8104 1088-1090 TO denotes to
T8105 1091-1097 VB denotes launch
T8106 1098-1101 CC denotes and
T8107 1102-1109 VB denotes amplify
T8108 1110-1112 DT denotes an
T8109 1113-1125 JJ denotes inflammatory
T8110 1126-1134 NN denotes response
T8111 1135-1136 -LRB- denotes [
T8112 1136-1138 CD denotes 32
T8113 1138-1139 -RRB- denotes ]
T8114 1141-1145 JJ denotes Such
T8115 1146-1155 NN denotes ‘sterile’
T8116 1156-1168 NN denotes inflammation
T8117 1169-1174 MD denotes could
T8118 1175-1177 VB denotes be
T8119 1178-1187 VB denotes initiated
T8120 1188-1191 CC denotes and
T8121 1192-1196 VB denotes take
T8122 1197-1202 NN denotes place
T8123 1203-1205 IN denotes in
T8124 1206-1209 DT denotes all
T8125 1210-1216 NN denotes organs
T8126 1217-1220 CC denotes and
T8127 1221-1228 NN denotes tissues
T8128 1229-1237 VB denotes affected
T8129 1238-1240 IN denotes in
T8130 1241-1245 NN denotes cpdm
T8131 1246-1250 NN denotes mice
T8132 1250-1251 -COMMA- denotes ,
T8133 1252-1256 RB denotes thus
T8134 1257-1264 VB denotes causing
T8135 1265-1276 JJ denotes multi-organ
T8136 1277-1289 JJ denotes inflammatory
T8137 1290-1299 NN denotes disorders
T8138 1301-1305 DT denotes This
T8139 1306-1316 NN denotes hypothesis
T8140 1317-1319 VB denotes is
T8141 1320-1329 VB denotes supported
T8142 1330-1332 IN denotes by
T8143 1333-1340 JJ denotes several
T8144 1341-1347 JJ denotes recent
T8145 1348-1355 NN denotes studies
T8146 1357-1368 NN denotes Fibroblasts
T8147 1369-1371 IN denotes of
T8148 1372-1376 NN denotes cpdm
T8149 1377-1381 NN denotes mice
T8150 1382-1385 VB denotes are
T8151 1386-1392 RB denotes highly
T8152 1393-1402 JJ denotes sensitive
T8153 1403-1405 TO denotes to
T8154 1406-1418 JJ denotes TNFα-induced
T8155 1419-1423 NN denotes cell
T8156 1424-1429 NN denotes death
T8157 1430-1433 CC denotes and
T8158 1434-1437 DT denotes the
T8159 1438-1442 NN denotes cpdm
T8160 1443-1452 NN denotes phenotype
T8161 1453-1456 MD denotes can
T8162 1457-1459 VB denotes be
T8163 1460-1469 RB denotes partially
T8164 1470-1477 VB denotes rescued
T8165 1478-1480 IN denotes by
T8166 1481-1489 NN denotes deletion
T8167 1490-1492 IN denotes of
T8168 1493-1496 NN denotes TNF
T8169 1497-1498 -LRB- denotes [
T8170 1498-1499 CD denotes 7
T8171 1499-1500 -RRB- denotes ]
T8172 1500-1501 -COMMA- denotes ,
T8173 1502-1503 -LRB- denotes [
T8174 1503-1504 CD denotes 8
T8175 1504-1505 -RRB- denotes ]
T8176 1505-1506 -COMMA- denotes ,
T8177 1507-1517 VB denotes suggesting
T8178 1518-1522 IN denotes that
T8179 1523-1533 NN denotes deficiency
T8180 1534-1536 IN denotes of
T8181 1537-1544 NN denotes SHARPIN
T8182 1545-1556 VB denotes compromises
T8183 1557-1560 DT denotes the
T8184 1561-1575 JJ denotes anti-apoptotic
T8185 1576-1586 NN denotes mechanisms
T8186 1587-1589 IN denotes in
T8187 1590-1594 NN denotes cpdm
T8188 1595-1599 NN denotes mice
T8189 1600-1609 VB denotes resulting
T8190 1610-1612 IN denotes in
T8191 1613-1617 NN denotes cell
T8192 1618-1631 JJ denotes death-induced
T8193 1632-1644 JJ denotes inflammatory
T8194 1645-1652 NN denotes disease
T8195 1654-1663 NN denotes Apoptosis
T8196 1664-1666 IN denotes of
T8197 1667-1680 NN denotes keratinocytes
T8198 1681-1683 VB denotes is
T8199 1684-1685 DT denotes a
T8200 1686-1695 JJ denotes prominent
T8201 1696-1703 NN denotes feature
T8202 1704-1706 IN denotes of
T8203 1707-1710 DT denotes the
T8204 1711-1715 NN denotes skin
T8205 1716-1723 NN denotes lesions
T8206 1724-1726 IN denotes in
T8207 1727-1731 NN denotes cpdm
T8208 1732-1736 NN denotes mice
T8209 1737-1738 -LRB- denotes [
T8210 1738-1740 CD denotes 33
T8211 1740-1741 -RRB- denotes ]
T8212 1742-1745 CC denotes and
T8213 1746-1750 DT denotes this
T8214 1751-1753 VB denotes is
T8215 1754-1762 VB denotes mediated
T8216 1763-1765 IN denotes by
T8217 1766-1783 JJ denotes caspase-dependent
T8218 1784-1797 JJ denotes mitochondrial
T8219 1798-1806 NN denotes pathways
T8220 1807-1808 -LRB- denotes [
T8221 1808-1810 CD denotes 34
T8222 1810-1811 -RRB- denotes ]
T8223 1813-1818 DT denotes These
T8224 1819-1826 VB denotes induced
T8225 1827-1833 CC denotes and/or
T8226 1834-1843 JJ denotes intrinsic
T8227 1844-1853 JJ denotes apoptotic
T8228 1854-1859 NN denotes cells
T8229 1860-1863 MD denotes can
T8230 1864-1871 VB denotes release
T8231 1872-1879 JJ denotes various
T8232 1880-1885 NN denotes types
T8233 1886-1888 IN denotes of
T8234 1889-1894 NN denotes DAMPs
T8235 1895-1899 WDT denotes that
T8236 1900-1905 VB denotes exert
T8237 1906-1911 PRP-DOLLAR- denotes their
T8238 1912-1928 JJ denotes pro-inflammatory
T8239 1929-1939 NN denotes properties
T8240 1940-1942 IN denotes by
T8241 1943-1953 VB denotes activating
T8242 1954-1956 NN denotes DC
T8243 1957-1964 IN denotes through
T8244 1965-1972 NN denotes pattern
T8245 1973-1984 NN denotes recognition
T8246 1985-1994 NN denotes receptors
T8247 1995-1996 -LRB- denotes [
T8248 1996-1998 CD denotes 32
T8249 1998-1999 -RRB- denotes ]
T8250 1999-2000 -COMMA- denotes ,
T8251 2001-2002 -LRB- denotes [
T8252 2002-2004 CD denotes 35
T8253 2004-2005 -RRB- denotes ]
T8254 2005-2006 -COMMA- denotes ,
T8255 2007-2011 JJ denotes such
T8256 2012-2014 IN denotes as
T8257 2015-2020 NN denotes HMGB1
T8258 2021-2031 VB denotes recognized
T8259 2032-2034 IN denotes by
T8260 2035-2041 NN denotes TLR2/4
T8261 2042-2043 -LRB- denotes [
T8262 2043-2045 CD denotes 36
T8263 2045-2046 -RRB- denotes ]
T8264 2046-2047 -COMMA- denotes ,
T8265 2048-2049 -LRB- denotes [
T8266 2049-2051 CD denotes 37
T8267 2051-2052 -RRB- denotes ]
T8268 2054-2064 JJ denotes Consistent
T8269 2065-2069 IN denotes with
T8270 2070-2073 DT denotes the
T8271 2074-2082 JJ denotes impaired
T8272 2083-2086 NN denotes Th1
T8273 2087-2093 JJ denotes immune
T8274 2094-2102 NN denotes response
T8275 2103-2105 IN denotes in
T8276 2106-2110 NN denotes cpdm
T8277 2111-2115 NN denotes mice
T8278 2116-2117 -LRB- denotes [
T8279 2117-2118 CD denotes 5
T8280 2118-2119 -RRB- denotes ]
T8281 2119-2120 -COMMA- denotes ,
T8282 2121-2131 VB denotes stimulated
T8283 2132-2136 NN denotes BMDC
T8284 2137-2143 RB denotes weakly
T8285 2144-2153 VB denotes polarized
T8286 2154-2157 NN denotes Th1
T8287 2158-2173 NN denotes differentiation
T8288 2173-2174 -COMMA- denotes ,
T8289 2175-2178 CC denotes but
T8290 2179-2187 RB denotes strongly
T8291 2188-2197 VB denotes supported
T8292 2198-2201 DT denotes the
T8293 2202-2213 NN denotes development
T8294 2214-2216 IN denotes of
T8295 2217-2220 NN denotes Th2
T8296 2221-2229 NN denotes effector
T8297 2230-2235 NN denotes cells
T8298 2237-2245 VB denotes Combined
T8299 2246-2250 IN denotes with
T8300 2251-2254 DT denotes the
T8301 2255-2263 JJ denotes dramatic
T8302 2264-2270 NN denotes effect
T8303 2271-2273 IN denotes of
T8304 2274-2278 NN denotes IL12
T8305 2279-2288 NN denotes treatment
T8306 2289-2291 IN denotes on
T8307 2292-2295 DT denotes the
T8308 2296-2305 NN denotes phenotype
T8309 2306-2308 IN denotes of
T8310 2309-2314 DT denotes these
T8311 2315-2319 NN denotes mice
T8312 2320-2321 -LRB- denotes [
T8313 2321-2322 CD denotes 5
T8314 2322-2323 -RRB- denotes ]
T8315 2323-2324 -COMMA- denotes ,
T8316 2325-2329 DT denotes this
T8317 2330-2338 VB denotes suggests
T8318 2339-2343 IN denotes that
T8319 2344-2347 DT denotes the
T8320 2348-2358 JJ denotes Th2-biased
T8321 2359-2367 JJ denotes systemic
T8322 2368-2380 NN denotes inflammation
T8323 2381-2383 IN denotes in
T8324 2384-2388 NN denotes cpdm
T8325 2389-2393 NN denotes mice
T8326 2394-2396 VB denotes is
T8327 2397-2403 VB denotes caused
T8328 2404-2406 IN denotes by
T8329 2407-2414 VB denotes reduced
T8330 2415-2422 NN denotes IL12P70
T8331 2423-2433 NN denotes production
T8332 2434-2438 IN denotes from
T8333 2439-2441 NN denotes DC
T8334 2443-2446 DT denotes The
T8335 2447-2457 NN denotes importance
T8336 2458-2460 IN denotes of
T8337 2461-2468 NN denotes IL12P70
T8338 2469-2471 IN denotes in
T8339 2472-2482 VB denotes regulating
T8340 2483-2486 NN denotes Th1
T8341 2487-2490 CC denotes and
T8342 2491-2494 NN denotes Th2
T8343 2495-2501 JJ denotes immune
T8344 2502-2511 NN denotes responses
T8345 2512-2514 IN denotes in
T8346 2515-2519 NN denotes mice
T8347 2520-2523 VB denotes was
T8348 2524-2531 RB denotes clearly
T8349 2532-2544 VB denotes demonstrated
T8350 2545-2547 IN denotes in
T8351 2548-2556 NN denotes IL12P35-
T8352 2557-2560 CC denotes and
T8353 2561-2578 JJ denotes IL12P40-deficient
T8354 2579-2583 NN denotes mice
T8355 2584-2585 -LRB- denotes [
T8356 2585-2587 CD denotes 38
T8357 2587-2588 -RRB- denotes ]
T8358 2588-2589 -COMMA- denotes ,
T8359 2590-2591 -LRB- denotes [
T8360 2591-2593 CD denotes 39
T8361 2593-2594 -RRB- denotes ]
T8362 2595-2598 CC denotes and
T8363 2599-2606 IN denotes through
T8364 2607-2615 JJ denotes clinical
T8365 2616-2623 NN denotes studies
T8366 2624-2626 IN denotes in
T8367 2627-2632 JJ denotes human
T8368 2633-2641 NN denotes patients
T8369 2642-2643 -LRB- denotes [
T8370 2643-2645 CD denotes 40
T8371 2645-2646 -RRB- denotes ]
T8372 2646-2647 CD denotes –
T8373 2647-2648 -LRB- denotes [
T8374 2648-2650 CD denotes 42
T8375 2650-2651 -RRB- denotes ]
T8376 2653-2658 NN denotes NF-κB
T8377 2658-2659 -COMMA- denotes ,
T8378 2660-2668 NN denotes TBK/IRF3
T8379 2668-2669 -COMMA- denotes ,
T8380 2670-2673 CC denotes and
T8381 2674-2678 NN denotes MAPK
T8382 2679-2688 NN denotes signaling
T8383 2689-2692 VB denotes are
T8384 2693-2702 JJ denotes important
T8385 2703-2711 NN denotes pathways
T8386 2712-2721 VB denotes activated
T8387 2722-2724 IN denotes by
T8388 2725-2728 NN denotes LPS
T8389 2729-2731 CC denotes or
T8390 2732-2736 NN denotes poly
T8391 2737-2738 NN denotes I
T8392 2738-2739 -COLON- denotes :
T8393 2739-2740 NN denotes C
T8394 2741-2744 CC denotes and
T8395 2745-2755 NN denotes disruption
T8396 2756-2758 IN denotes of
T8397 2759-2765 DT denotes either
T8398 2766-2773 NN denotes pathway
T8399 2774-2777 MD denotes may
T8400 2778-2782 VB denotes lead
T8401 2783-2785 TO denotes to
T8402 2786-2795 VB denotes decreased
T8403 2796-2804 NN denotes cytokine
T8404 2805-2815 NN denotes expression
T8405 2817-2822 NN denotes NF-κB
T8406 2823-2833 NN denotes activation
T8407 2834-2837 VB denotes was
T8408 2838-2849 RB denotes selectively
T8409 2850-2859 VB denotes inhibited
T8410 2860-2862 IN denotes in
T8411 2863-2866 NN denotes LPS
T8412 2867-2870 CC denotes and
T8413 2871-2875 NN denotes poly
T8414 2876-2877 NN denotes I
T8415 2877-2878 SYM denotes :
T8416 2878-2879 NN denotes C
T8417 2880-2890 VB denotes stimulated
T8418 2891-2895 NN denotes cpdm
T8419 2896-2900 NN denotes BMDC
T8420 2901-2909 VB denotes compared
T8421 2910-2912 TO denotes to
T8422 2913-2917 JJ denotes wild
T8423 2918-2922 NN denotes type
T8424 2922-2923 -COMMA- denotes ,
T8425 2924-2929 IN denotes while
T8426 2930-2940 NN denotes activation
T8427 2941-2943 IN denotes of
T8428 2944-2953 NN denotes TBK1/IRF3
T8429 2953-2954 -COMMA- denotes ,
T8430 2955-2961 NN denotes ERK1/2
T8431 2961-2962 -COMMA- denotes ,
T8432 2963-2965 CC denotes or
T8433 2966-2969 NN denotes p38
T8434 2970-2973 VB denotes was
T8435 2974-2977 RB denotes not
T8436 2977-2978 -COMMA- denotes ,
T8437 2979-2989 VB denotes indicating
T8438 2990-2994 IN denotes that
T8439 2995-3004 VB denotes disrupted
T8440 3005-3010 NN denotes NF-κB
T8441 3011-3020 NN denotes signaling
T8442 3021-3023 IN denotes in
T8443 3024-3028 NN denotes cpdm
T8444 3029-3031 NN denotes DC
T8445 3032-3034 VB denotes is
T8446 3035-3046 JJ denotes responsible
T8447 3047-3050 IN denotes for
T8448 3051-3054 DT denotes the
T8449 3055-3064 JJ denotes defective
T8450 3065-3073 NN denotes cytokine
T8451 3074-3084 NN denotes expression
T8452 3086-3091 DT denotes These
T8453 3092-3099 NN denotes results
T8454 3100-3104 VB denotes seem
T8455 3105-3107 TO denotes to
T8456 3108-3118 VB denotes contradict
T8457 3119-3120 DT denotes a
T8458 3121-3127 JJ denotes recent
T8459 3128-3133 NN denotes study
T8460 3134-3138 WDT denotes that
T8461 3139-3144 VB denotes found
T8462 3145-3154 VB denotes increased
T8463 3155-3161 NN denotes levels
T8464 3162-3164 IN denotes of
T8465 3165-3170 NN denotes NF-κB
T8466 3171-3181 NN denotes activation
T8467 3182-3185 CC denotes and
T8468 3186-3189 NN denotes IL1
T8469 3190-3203 NN denotes transcription
T8470 3204-3206 IN denotes in
T8471 3207-3211 NN denotes cpdm
T8472 3212-3216 NN denotes mice
T8473 3217-3218 -LRB- denotes [
T8474 3218-3220 CD denotes 43
T8475 3220-3221 -RRB- denotes ]
T8476 3223-3227 DT denotes This
T8477 3228-3238 NN denotes difference
T8478 3239-3242 MD denotes can
T8479 3243-3251 RB denotes probably
T8480 3252-3254 VB denotes be
T8481 3255-3265 VB denotes attributed
T8482 3266-3268 TO denotes to
T8483 3269-3272 DT denotes the
T8484 3273-3282 JJ denotes different
T8485 3283-3288 NN denotes cells
T8486 3289-3292 CC denotes and
T8487 3293-3300 NN denotes tissues
T8488 3301-3305 VB denotes used
T8489 3306-3308 IN denotes in
T8490 3309-3314 DT denotes these
T8491 3315-3322 NN denotes studies
T8492 3322-3323 -COMMA- denotes ,
T8493 3324-3327 CC denotes and
T8494 3328-3331 MD denotes may
T8495 3332-3337 VB denotes point
T8496 3338-3340 TO denotes to
T8497 3341-3346 NN denotes cell-
T8498 3347-3350 CC denotes and
T8499 3351-3358 NN denotes tissue-
T8500 3359-3363 NN denotes type
T8501 3364-3372 JJ denotes specific
T8502 3373-3382 NN denotes functions
T8503 3383-3385 IN denotes of
T8504 3386-3393 NN denotes SHARPIN
T8505 3395-3399 DT denotes This
T8506 3400-3402 VB denotes is
T8507 3403-3413 JJ denotes consistent
T8508 3414-3418 IN denotes with
T8509 3419-3425 JJ denotes recent
T8510 3426-3433 NN denotes reports
T8511 3434-3436 IN denotes of
T8512 3437-3452 JJ denotes tissue-specific
T8513 3453-3460 NN denotes effects
T8514 3461-3463 IN denotes of
T8515 3464-3469 NN denotes NF-κB
T8516 3470-3479 NN denotes signaling
T8517 3480-3481 -LRB- denotes [
T8518 3481-3483 CD denotes 44
T8519 3483-3484 -RRB- denotes ]
T8520 3486-3496 JJ denotes Ubiquitous
T8521 3497-3507 NN denotes activation
T8522 3508-3510 IN denotes of
T8523 3511-3516 NN denotes NF-κB
T8524 3517-3519 IN denotes by
T8525 3520-3528 VB denotes removing
T8526 3529-3539 NN denotes inhibitors
T8527 3540-3544 JJ denotes such
T8528 3545-3547 IN denotes as
T8529 3548-3551 NN denotes A20
T8530 3552-3555 CC denotes and
T8531 3556-3560 NN denotes ITCH
T8532 3561-3568 IN denotes through
T8533 3569-3576 JJ denotes genetic
T8534 3577-3589 NN denotes manipulation
T8535 3590-3597 VB denotes results
T8536 3598-3600 IN denotes in
T8537 3601-3611 JJ denotes widespread
T8538 3612-3624 NN denotes inflammation
T8539 3624-3625 -COMMA- denotes ,
T8540 3626-3636 JJ denotes consistent
T8541 3637-3641 IN denotes with
T8542 3642-3645 DT denotes the
T8543 3646-3650 NN denotes role
T8544 3651-3653 IN denotes of
T8545 3654-3659 NN denotes NF-κB
T8546 3660-3662 IN denotes in
T8547 3663-3666 DT denotes the
T8548 3667-3677 NN denotes production
T8549 3678-3680 IN denotes of
T8550 3681-3697 JJ denotes pro-inflammatory
T8551 3698-3707 NN denotes mediators
T8552 3708-3709 -LRB- denotes [
T8553 3709-3711 CD denotes 45
T8554 3711-3712 -RRB- denotes ]
T8555 3712-3713 -COMMA- denotes ,
T8556 3714-3715 -LRB- denotes [
T8557 3715-3717 CD denotes 46
T8558 3717-3718 -RRB- denotes ]
T8559 3720-3727 RB denotes However
T8560 3727-3728 -COMMA- denotes ,
T8561 3729-3738 JJ denotes selective
T8562 3739-3749 NN denotes inhibition
T8563 3750-3752 IN denotes of
T8564 3753-3758 NN denotes NF-κB
T8565 3759-3769 NN denotes activation
T8566 3770-3772 IN denotes in
T8567 3773-3784 JJ denotes parenchymal
T8568 3785-3790 NN denotes cells
T8569 3791-3793 IN denotes of
T8570 3794-3797 DT denotes the
T8571 3798-3802 NN denotes skin
T8572 3802-3803 -COMMA- denotes ,
T8573 3804-3809 NN denotes liver
T8574 3809-3810 -COMMA- denotes ,
T8575 3811-3814 CC denotes and
T8576 3815-3824 NN denotes intestine
T8577 3825-3832 VB denotes results
T8578 3833-3835 IN denotes in
T8579 3836-3843 JJ denotes chronic
T8580 3844-3856 NN denotes inflammation
T8581 3857-3863 VB denotes driven
T8582 3864-3866 IN denotes by
T8583 3867-3872 NN denotes NF-κB
T8584 3873-3882 JJ denotes competent
T8585 3883-3893 NN denotes leukocytes
T8586 3894-3895 -LRB- denotes [
T8587 3895-3897 CD denotes 47
T8588 3897-3898 -RRB- denotes ]
T8589 3898-3899 CD denotes –
T8590 3899-3900 -LRB- denotes [
T8591 3900-3902 CD denotes 50
T8592 3902-3903 -RRB- denotes ]
T8593 3905-3909 DT denotes This
T8594 3910-3919 VB denotes indicates
T8595 3920-3924 IN denotes that
T8596 3925-3926 DT denotes a
T8597 3927-3934 NN denotes balance
T8598 3935-3942 IN denotes between
T8599 3943-3946 DT denotes the
T8600 3947-3963 JJ denotes pro-inflammatory
T8601 3964-3968 NN denotes role
T8602 3969-3971 IN denotes of
T8603 3972-3977 NN denotes NF-κB
T8604 3978-3980 IN denotes in
T8605 3981-3991 NN denotes leukocytes
T8606 3992-3995 CC denotes and
T8607 3996-3999 DT denotes the
T8608 4000-4017 JJ denotes anti-inflammatory
T8609 4018-4022 NN denotes role
T8610 4023-4025 IN denotes in
T8611 4026-4037 JJ denotes parenchymal
T8612 4038-4043 NN denotes cells
T8613 4044-4046 VB denotes is
T8614 4047-4055 JJ denotes critical
T8615 4056-4058 IN denotes in
T8616 4059-4062 DT denotes the
T8617 4063-4074 NN denotes maintenance
T8618 4075-4077 IN denotes of
T8619 4078-4084 NN denotes tissue
T8620 4085-4096 NN denotes homeostasis
T8621 4098-4109 NN denotes Experiments
T8622 4110-4114 IN denotes with
T8623 4115-4119 NN denotes mice
T8624 4120-4124 IN denotes with
T8625 4125-4130 NN denotes cell-
T8626 4131-4134 CC denotes and
T8627 4135-4150 JJ denotes tissue-specific
T8628 4151-4159 NN denotes deletion
T8629 4160-4162 IN denotes of
T8630 4163-4170 NNP denotes Sharpin
T8631 4170-4171 -COMMA- denotes ,
T8632 4172-4181 RB denotes currently
T8633 4182-4187 IN denotes under
T8634 4188-4191 NN denotes way
T8635 4191-4192 -COMMA- denotes ,
T8636 4193-4197 MD denotes will
T8637 4198-4202 VB denotes help
T8638 4203-4205 TO denotes to
T8639 4206-4215 VB denotes elucidate
T8640 4216-4219 DT denotes the
T8641 4220-4224 NN denotes role
T8642 4225-4227 IN denotes of
T8643 4228-4235 NN denotes SHARPIN
T8644 4236-4238 IN denotes in
T8645 4239-4251 NN denotes inflammation
T8646 4253-4260 IN denotes Despite
T8647 4261-4270 JJ denotes defective
T8648 4271-4276 NN denotes NF-κB
T8649 4277-4287 NN denotes activation
T8650 4288-4290 IN denotes in
T8651 4291-4294 DT denotes the
T8652 4295-4302 NN denotes absence
T8653 4303-4305 IN denotes of
T8654 4306-4313 NN denotes Sharpin
T8655 4314-4324 NN denotes expression
T8656 4324-4325 -COMMA- denotes ,
T8657 4326-4331 EX denotes there
T8658 4332-4335 VB denotes was
T8659 4336-4338 DT denotes no
T8660 4339-4350 JJ denotes significant
T8661 4351-4357 NN denotes change
T8662 4358-4360 IN denotes in
T8663 4361-4368 JJ denotes splenic
T8664 4369-4371 NN denotes DC
T8665 4372-4383 NN denotes populations
T8666 4384-4386 CC denotes or
T8667 4387-4397 NN denotes expression
T8668 4398-4400 IN denotes of
T8669 4401-4415 JJ denotes co-stimulatory
T8670 4416-4425 NN denotes molecules
T8671 4426-4428 IN denotes on
T8672 4429-4433 NN denotes BMDC
T8673 4435-4444 JJ denotes Different
T8674 4445-4450 NN denotes NF-κB
T8675 4451-4459 NN denotes subunits
T8676 4460-4468 VB denotes involved
T8677 4469-4471 IN denotes in
T8678 4472-4475 DT denotes the
T8679 4476-4485 JJ denotes canonical
T8680 4486-4489 CC denotes and
T8681 4490-4503 JJ denotes non-canonical
T8682 4504-4512 NN denotes branches
T8683 4513-4515 IN denotes of
T8684 4516-4519 DT denotes the
T8685 4520-4525 NN denotes NF-κB
T8686 4526-4535 NN denotes signaling
T8687 4536-4543 NN denotes pathway
T8688 4544-4548 VB denotes have
T8689 4549-4557 JJ denotes distinct
T8690 4558-4567 NN denotes functions
T8691 4568-4570 TO denotes to
T8692 4571-4578 VB denotes control
T8693 4579-4587 JJ denotes specific
T8694 4588-4595 NN denotes aspects
T8695 4596-4598 IN denotes of
T8696 4599-4601 NN denotes DC
T8697 4602-4613 NN denotes development
T8698 4614-4617 CC denotes and
T8699 4618-4626 NN denotes function
T8700 4627-4628 -LRB- denotes [
T8701 4628-4630 CD denotes 51
T8702 4630-4631 -RRB- denotes ]
T8703 4631-4632 -COMMA- denotes ,
T8704 4633-4634 -LRB- denotes [
T8705 4634-4636 CD denotes 52
T8706 4636-4637 -RRB- denotes ]
T8707 4639-4642 DT denotes The
T8708 4643-4656 JJ denotes non-canonical
T8709 4657-4664 NN denotes pathway
T8710 4665-4666 -LRB- denotes (
T8711 4666-4670 NN denotes p100
T8712 4671-4681 NN denotes processing
T8713 4682-4684 TO denotes to
T8714 4685-4692 VB denotes produce
T8715 4693-4696 NN denotes p52
T8716 4696-4697 -RRB- denotes )
T8717 4698-4705 VB denotes appears
T8718 4706-4708 TO denotes to
T8719 4709-4711 VB denotes be
T8720 4712-4718 JJ denotes intact
T8721 4719-4721 IN denotes in
T8722 4722-4739 JJ denotes SHARPIN-deficient
T8723 4740-4745 NN denotes cells
T8724 4746-4747 -LRB- denotes [
T8725 4747-4748 CD denotes 7
T8726 4748-4749 -RRB- denotes ]
T8727 4749-4750 -COMMA- denotes ,
T8728 4751-4752 -LRB- denotes [
T8729 4752-4753 CD denotes 9
T8730 4753-4754 -RRB- denotes ]
T8731 4755-4765 VB denotes suggesting
T8732 4766-4770 IN denotes that
T8733 4771-4774 DT denotes the
T8734 4775-4780 NN denotes NF-κB
T8735 4781-4792 NN denotes heterodimer
T8736 4793-4801 NN denotes p52/RELB
T8737 4802-4804 VB denotes is
T8738 4805-4815 JJ denotes sufficient
T8739 4816-4818 TO denotes to
T8740 4819-4827 VB denotes maintain
T8741 4828-4831 DT denotes the
T8742 4832-4838 JJ denotes normal
T8743 4839-4849 NN denotes regulation
T8744 4850-4852 IN denotes of
T8745 4853-4855 NN denotes DC
T8746 4856-4867 NN denotes homeostasis
T8747 4868-4871 CC denotes and
T8748 4872-4882 NN denotes maturation
T8749 4884-4887 DT denotes The
T8750 4888-4897 JJ denotes molecular
T8751 4898-4903 NN denotes basis
T8752 4904-4906 IN denotes by
T8753 4907-4912 WDT denotes which
T8754 4913-4916 DT denotes the
T8755 4917-4924 NNP denotes Sharpin
T8756 4925-4933 NN denotes mutation
T8757 4934-4940 VB denotes causes
T8758 4941-4948 VB denotes reduced
T8759 4949-4954 NN denotes NF-κB
T8760 4955-4965 NN denotes activation
T8761 4966-4968 IN denotes in
T8762 4969-4973 NN denotes BMDC
T8763 4974-4981 VB denotes remains
T8764 4982-4984 TO denotes to
T8765 4985-4987 VB denotes be
T8766 4988-4998 VB denotes determined
T8767 5000-5003 NN denotes LPS
T8768 5004-5007 CC denotes and
T8769 5008-5012 NN denotes poly
T8770 5013-5014 NN denotes I
T8771 5014-5015 -COLON- denotes :
T8772 5015-5016 NN denotes C
T8773 5017-5021 VB denotes used
T8774 5022-5026 RB denotes here
T8775 5027-5030 VB denotes are
T8776 5031-5043 JJ denotes well-defined
T8777 5044-5051 NN denotes ligands
T8778 5052-5056 WDT denotes that
T8779 5057-5069 RB denotes specifically
T8780 5070-5076 VB denotes engage
T8781 5077-5081 NN denotes TLR4
T8782 5082-5085 CC denotes and
T8783 5086-5090 NN denotes TLR3
T8784 5090-5091 -COMMA- denotes ,
T8785 5092-5104 RB denotes respectively
T8786 5106-5109 DT denotes The
T8787 5110-5120 NN denotes expression
T8788 5121-5128 NN denotes profile
T8789 5129-5131 IN denotes of
T8790 5132-5139 NN denotes surface
T8791 5140-5144 NN denotes TLR4
T8792 5145-5154 NN denotes complexes
T8793 5155-5157 VB denotes is
T8794 5158-5165 JJ denotes similar
T8795 5166-5173 IN denotes between
T8796 5174-5176 NN denotes WT
T8797 5177-5180 CC denotes and
T8798 5181-5185 NN denotes cpdm
T8799 5186-5190 NN denotes BMDC
T8800 5191-5201 VB denotes suggesting
T8801 5202-5206 IN denotes that
T8802 5207-5216 JJ denotes defective
T8803 5217-5222 NN denotes NF-κB
T8804 5223-5233 NN denotes activation
T8805 5234-5236 VB denotes is
T8806 5237-5240 RB denotes not
T8807 5241-5242 DT denotes a
T8808 5243-5249 NN denotes result
T8809 5250-5252 IN denotes of
T8810 5253-5265 JJ denotes differential
T8811 5266-5269 NN denotes TLR
T8812 5270-5280 NN denotes expression
T8813 5281-5283 IN denotes on
T8814 5284-5290 NN denotes target
T8815 5291-5296 NN denotes cells
T8816 5298-5301 NN denotes LPS
T8817 5302-5309 VB denotes engages
T8818 5310-5314 NN denotes TLR4
T8819 5315-5317 TO denotes to
T8820 5318-5326 VB denotes activate
T8821 5327-5342 JJ denotes MYD88-dependent
T8822 5343-5346 CC denotes and
T8823 5347-5361 JJ denotes TRIF-dependent
T8824 5362-5370 NN denotes pathways
T8825 5370-5371 -COMMA- denotes ,
T8826 5372-5379 IN denotes whereas
T8827 5380-5384 NN denotes TLR3
T8828 5385-5395 VB denotes stimulated
T8829 5396-5398 IN denotes by
T8830 5399-5403 NN denotes poly
T8831 5404-5405 NN denotes I
T8832 5405-5406 -COLON- denotes :
T8833 5406-5407 NN denotes C
T8834 5408-5412 RB denotes only
T8835 5413-5421 VB denotes triggers
T8836 5422-5436 JJ denotes TRIF-dependent
T8837 5437-5446 NN denotes signaling
T8838 5447-5448 -LRB- denotes [
T8839 5448-5450 CD denotes 53
T8840 5450-5451 -RRB- denotes ]
T8841 5453-5456 DT denotes The
T8842 5457-5466 JJ denotes defective
T8843 5467-5472 NN denotes NF-κB
T8844 5473-5483 NN denotes activation
T8845 5484-5486 IN denotes by
T8846 5487-5491 DT denotes both
T8847 5492-5499 NN denotes stimuli
T8848 5500-5508 VB denotes suggests
T8849 5509-5513 IN denotes that
T8850 5514-5517 DT denotes the
T8851 5518-5525 NNP denotes Sharpin
T8852 5526-5534 NN denotes mutation
T8853 5535-5545 VB denotes interferes
T8854 5546-5550 IN denotes with
T8855 5551-5554 DT denotes the
T8856 5555-5562 NN denotes protein
T8857 5563-5571 NN denotes adaptors
T8858 5572-5574 CC denotes or
T8859 5575-5582 NN denotes kinases
T8860 5583-5589 VB denotes shared
T8861 5590-5592 IN denotes by
T8862 5593-5597 CC denotes both
T8863 5598-5607 NN denotes signaling
T8864 5608-5616 NN denotes pathways
T8865 5616-5617 -COMMA- denotes ,
T8866 5618-5622 JJ denotes such
T8867 5623-5625 IN denotes as
T8868 5626-5630 NN denotes RIP1
T8869 5631-5634 CC denotes and
T8870 5635-5640 NN denotes TRAF6
T8871 5641-5642 -LRB- denotes [
T8872 5642-5644 CD denotes 18
T8873 5644-5645 -RRB- denotes ]
T8874 5647-5653 JJ denotes Recent
T8875 5654-5661 NN denotes studies
T8876 5662-5674 VB denotes demonstrated
T8877 5675-5679 IN denotes that
T8878 5680-5687 NN denotes SHARPIN
T8879 5688-5697 VB denotes interacts
T8880 5698-5702 IN denotes with
T8881 5703-5707 NN denotes HOIP
T8882 5708-5710 TO denotes to
T8883 5711-5715 VB denotes form
T8884 5716-5721 NN denotes LUBAC
T8885 5722-5726 WDT denotes that
T8886 5727-5733 VB denotes exerts
T8887 5734-5737 PRP-DOLLAR- denotes its
T8888 5738-5767 NN denotes linear-ubiquitin-chain-ligase
T8889 5768-5776 NN denotes activity
T8890 5777-5779 IN denotes on
T8891 5780-5785 NN denotes NF-κB
T8892 5786-5795 NN denotes signaling
T8893 5796-5803 NN denotes players
T8894 5804-5808 NN denotes RIP1
T8895 5809-5812 CC denotes and
T8896 5813-5817 NN denotes NEMO
T8897 5818-5819 -LRB- denotes [
T8898 5819-5820 CD denotes 7
T8899 5820-5821 -RRB- denotes ]
T8900 5821-5822 -COMMA- denotes ,
T8901 5823-5825 DT denotes an
T8902 5826-5835 JJ denotes essential
T8903 5836-5840 NN denotes step
T8904 5841-5844 IN denotes for
T8905 5845-5851 JJ denotes intact
T8906 5852-5867 JJ denotes TNFα-stimulated
T8907 5868-5873 NN denotes NF-κB
T8908 5874-5884 NN denotes activation
T8909 5886-5889 DT denotes The
T8910 5890-5897 NNP denotes Sharpin
T8911 5898-5902 JJ denotes null
T8912 5903-5911 NN denotes mutation
T8913 5912-5920 VB denotes disrupts
T8914 5921-5924 DT denotes the
T8915 5925-5939 NN denotes ubiquitylation
T8916 5940-5947 NN denotes process
T8917 5948-5951 CC denotes and
T8918 5952-5961 VB denotes abrogates
T8919 5962-5965 DT denotes the
T8920 5966-5978 JJ denotes TNFα-induced
T8921 5979-5984 NN denotes NF-κB
T8922 5985-5994 NN denotes signaling
T8923 5995-6002 NN denotes pathway
T8924 6004-6009 IN denotes Since
T8925 6010-6014 NN denotes TNFR
T8926 6015-6018 CC denotes and
T8927 6019-6022 NN denotes TLR
T8928 6023-6032 RB denotes partially
T8929 6033-6038 VB denotes share
T8930 6039-6044 PRP-DOLLAR- denotes their
T8931 6045-6055 JJ denotes downstream
T8932 6056-6065 NN denotes signaling
T8933 6066-6074 NN denotes cascades
T8934 6074-6075 -COMMA- denotes ,
T8935 6076-6077 DT denotes a
T8936 6078-6085 JJ denotes similar
T8937 6086-6104 JJ denotes ubiquitin-mediated
T8938 6105-6115 NN denotes regulation
T8939 6116-6119 MD denotes may
T8940 6120-6124 VB denotes hold
T8941 6125-6129 JJ denotes true
T8942 6130-6133 IN denotes for
T8943 6134-6141 NN denotes SHARPIN
T8944 6142-6144 IN denotes in
T8945 6145-6149 NN denotes LPS-
T8946 6150-6153 CC denotes and
T8947 6154-6158 NN denotes poly
T8948 6159-6160 CD denotes I
T8949 6160-6161 -COLON- denotes :
T8950 6161-6170 JJ denotes C-induced
T8951 6171-6176 NN denotes NF-κB
T8952 6177-6187 NN denotes activation
T8953 6189-6191 IN denotes In
T8954 6192-6199 NN denotes summary
T8955 6199-6200 -COMMA- denotes ,
T8956 6201-6204 DT denotes the
T8957 6205-6212 JJ denotes present
T8958 6213-6218 NN denotes study
T8959 6219-6229 VB denotes identified
T8960 6230-6232 DT denotes an
T8961 6233-6246 JJ denotes indispensible
T8962 6247-6251 NN denotes role
T8963 6252-6254 IN denotes of
T8964 6255-6262 NN denotes SHARPIN
T8965 6263-6265 IN denotes in
T8966 6266-6269 DT denotes the
T8967 6270-6280 NN denotes production
T8968 6281-6283 IN denotes of
T8969 6284-6300 JJ denotes pro-inflammatory
T8970 6301-6310 NN denotes mediators
T8971 6311-6314 CC denotes and
T8972 6315-6326 JJ denotes TLR-induced
T8973 6327-6332 NN denotes NF-κB
T8974 6333-6342 NN denotes signaling
T8975 6344-6347 DT denotes The
T8976 6348-6356 JJ denotes impaired
T8977 6357-6372 JJ denotes Th1-stimulating
T8978 6373-6380 NN denotes ability
T8979 6381-6383 IN denotes of
T8980 6384-6401 JJ denotes Sharpin-deficient
T8981 6402-6404 NN denotes DC
T8982 6405-6408 MD denotes may
T8983 6409-6416 VB denotes account
T8984 6417-6420 IN denotes for
T8985 6421-6424 DT denotes the
T8986 6425-6437 JJ denotes Th2-dominant
T8987 6438-6450 JJ denotes inflammatory
T8988 6451-6460 NN denotes phenotype
T8989 6461-6463 IN denotes of
T8990 6464-6468 NN denotes cpdm
T8991 6469-6473 NN denotes mice
T8992 6475-6478 DT denotes The
T8993 6479-6486 NN denotes balance
T8994 6487-6494 IN denotes between
T8995 6495-6498 NN denotes Th1
T8996 6499-6502 CC denotes and
T8997 6503-6506 NN denotes Th2
T8998 6507-6522 NN denotes differentiation
T8999 6523-6525 VB denotes is
T9000 6526-6534 JJ denotes critical
T9001 6535-6538 IN denotes for
T9002 6539-6545 JJ denotes immune
T9003 6546-6557 NN denotes homeostasis
T9004 6559-6560 DT denotes A
T9005 6561-6567 JJ denotes better
T9006 6568-6581 NN denotes understanding
T9007 6582-6584 IN denotes of
T9008 6585-6588 WRB denotes how
T9009 6589-6593 JJ denotes such
T9010 6594-6601 NN denotes balance
T9011 6602-6604 VB denotes is
T9012 6605-6615 VB denotes maintained
T9013 6616-6620 MD denotes will
T9014 6621-6625 VB denotes help
T9015 6626-6632 VB denotes design
T9016 6633-6641 NN denotes cytokine
T9017 6642-6651 NN denotes treatment
T9018 6652-6655 IN denotes for
T9019 6656-6661 JJ denotes human
T9020 6662-6670 NN denotes diseases
T9021 6671-6675 IN denotes with
T9022 6676-6686 JJ denotes Th2-biased
T9023 6687-6695 NN denotes cytokine
T9024 6696-6705 NN denotes secretion
T9025 6706-6713 JJ denotes similar
T9026 6714-6716 TO denotes to
T9027 6717-6720 DT denotes the
T9028 6721-6726 NN denotes mouse
T9029 6727-6731 NN denotes cpdm
T9030 6731-6732 -COMMA- denotes ,
T9031 6733-6737 JJ denotes such
T9032 6738-6740 IN denotes as
T9033 6741-6750 NN denotes allergies
T9034 6751-6754 CC denotes and
T9035 6755-6772 JJ denotes hypereosinophilic
T9036 6773-6782 NN denotes syndromes
R6548 T7944 T7942 arg1Of report,The
R6549 T7944 T7943 arg1Of report,present
R6550 T7944 T7945 arg1Of report,showed
R6551 T7948 T7947 arg1Of mutations,null
R6552 T7948 T7949 arg1Of mutations,of
R6553 T7948 T7954 arg1Of mutations,did
R6554 T7948 T7956 arg1Of mutations,affect
R6558 T7953 T7952 arg1Of gene,Sharpin
R6559 T7956 T7945 arg2Of affect,showed
R6560 T7956 T7946 arg1Of affect,that
R6561 T7956 T7954 arg2Of affect,did
R6562 T7956 T7955 arg1Of affect,not
R6563 T7959 T7957 arg1Of distribution,the
R6564 T7959 T7958 arg1Of distribution,steady-state
R6565 T7959 T7960 arg1Of distribution,of
R6566 T7959 T7964 arg1Of distribution,nor
R6567 T7963 T7960 arg2Of subsets,of
R6568 T7963 T7961 arg1Of subsets,splenic
R6569 T7963 T7962 arg1Of subsets,DC
R6570 T7964 T7956 arg2Of nor,affect
R6571 T7966 T7967 arg1Of development,and
R6572 T7967 T7964 arg2Of and,nor
R6573 T7967 T7965 arg1Of and,the
R6574 T7967 T7969 arg1Of and,of
R6575 T7968 T7967 arg2Of phenotype,and
R6576 T7970 T7969 arg2Of BMDC,of
R6577 T7973 T7974 arg1Of loss,of
R6578 T7973 T7977 arg1Of loss,diminished
R6579 T7975 T7974 arg2Of SHARPIN,of
R6580 T7977 T7971 arg1Of diminished,However
R6581 T7977 T7972 arg1Of diminished,","
R6582 T7977 T7976 arg1Of diminished,significantly
R6583 T7979 T7977 arg2Of capacity,diminished
R6584 T7979 T7978 arg1Of capacity,the
R6585 T7979 T7980 arg1Of capacity,of
R6586 T7979 T7982 modOf capacity,to
R6587 T7981 T7980 arg2Of BMDC,of
R6588 T7983 T7982 arg1Of secrete,to
R6589 T7985 T7984 arg1Of cytokines,inflammatory
R6590 T7985 T7986 arg1Of cytokines,and
R6591 T7986 T7983 arg2Of and,secrete
R6592 T7988 T7986 arg2Of oxide,and
R6593 T7988 T7987 arg1Of oxide,nitric
R6594 T7992 T7989 arg1Of production,The
R6595 T7992 T7990 arg2Of production,attenuated
R6596 T7992 T7991 arg1Of production,cytokine
R6597 T7992 T7993 arg1Of production,was
R6598 T7992 T7995 arg1Of production,due
R6599 T7992 T8004 arg1Of production,can
R6600 T7992 T8005 arg1Of production,be
R6601 T7992 T8007 arg2Of production,explained
R6602 T7993 T7994 arg1Of was,not
R6603 T7993 T8003 arg1Of was,and
R6604 T7995 T7993 arg2Of due,was
R6605 T7995 T7996 arg1Of due,to
R6606 T7998 T7996 arg2Of presence,to
R6607 T7998 T7997 arg1Of presence,the
R6608 T7998 T7999 arg1Of presence,of
R6609 T8001 T7999 arg2Of inhibitors,of
R6610 T8001 T8000 arg1Of inhibitors,anti-inflammatory
R6611 T8003 T8002 arg1Of and,","
R6612 T8007 T8003 arg2Of explained,and
R6613 T8007 T8004 arg2Of explained,can
R6614 T8007 T8005 arg2Of explained,be
R6615 T8007 T8006 arg1Of explained,largely
R6616 T8007 T8008 arg1Of explained,by
R6617 T8010 T8008 arg2Of inactivation,by
R6618 T8010 T8009 arg1Of inactivation,selective
R6619 T8010 T8011 arg1Of inactivation,of
R6620 T8013 T8011 arg2Of signaling,of
R6621 T8013 T8012 arg1Of signaling,NF-κB
R6622 T8016 T8014 arg2Of BMDC,Stimulated
R6623 T8016 T8015 arg1Of BMDC,cpdm
R6624 T8016 T8017 arg1Of BMDC,exhibited
R6625 T8017 T8022 arg1Of exhibited,","
R6626 T8017 T8023 arg1Of exhibited,consistent
R6627 T8021 T8017 arg2Of capabilities,exhibited
R6628 T8021 T8018 arg1Of capabilities,Th2-biased
R6629 T8021 T8019 arg1Of capabilities,T
R6630 T8021 T8020 arg1Of capabilities,cell-polarizing
R6631 T8023 T8024 arg1Of consistent,with
R6632 T8028 T8024 arg2Of phenotype,with
R6633 T8028 T8025 arg1Of phenotype,the
R6634 T8028 T8026 arg1Of phenotype,Th2
R6635 T8028 T8027 arg1Of phenotype,cytokine-dominant
R6636 T8028 T8029 arg1Of phenotype,in
R6637 T8031 T8029 arg2Of mice,in
R6638 T8031 T8030 arg1Of mice,cpdm
R6639 T8035 T8034 arg1Of results,these
R6640 T8035 T8036 arg1Of results,indicate
R6641 T8036 T8032 arg1Of indicate,Together
R6642 T8036 T8033 arg1Of indicate,","
R6643 T8039 T8036 arg2Of role,indicate
R6644 T8039 T8037 arg1Of role,an
R6645 T8039 T8038 arg1Of role,indispensible
R6646 T8039 T8040 arg1Of role,of
R6647 T8041 T8040 arg2Of SHARPIN,of
R6648 T8041 T8042 arg1Of SHARPIN,in
R6649 T8043 T8042 arg2Of regulating,in
R6650 T8046 T8043 arg2Of functions,regulating
R6651 T8046 T8044 arg1Of functions,DC
R6652 T8046 T8045 arg1Of functions,immunological
R6653 T8046 T8049 arg2Of functions,of
R6654 T8046 T8050 arg1Of functions,which
R6655 T8048 T8049 arg1Of disruption,of
R6656 T8048 T8051 arg1Of disruption,may
R6657 T8048 T8052 arg1Of disruption,contribute
R6658 T8052 T8047 arg1Of contribute,","
R6659 T8052 T8051 arg2Of contribute,may
R6660 T8052 T8053 arg1Of contribute,to
R6661 T8055 T8053 arg2Of development,to
R6662 T8055 T8054 arg1Of development,the
R6663 T8055 T8056 arg1Of development,of
R6664 T8058 T8056 arg2Of diseases,of
R6665 T8058 T8057 arg1Of diseases,immune
R6666 T8060 T8061 arg1Of WT,and
R6667 T8062 T8061 arg2Of cpdm,and
R6668 T8063 T8060 arg1Of mice,WT
R6669 T8063 T8062 arg1Of mice,cpdm
R6670 T8063 T8064 arg1Of mice,are
R6671 T8064 T8059 arg2Of are,Since
R6672 T8067 T8064 arg2Of pathogen-free,are
R6673 T8067 T8065 arg1Of pathogen-free,both
R6674 T8067 T8066 arg1Of pathogen-free,specific
R6675 T8070 T8069 arg1Of nature,the
R6676 T8070 T8071 arg1Of nature,of
R6677 T8070 T8081 arg1Of nature,is
R6678 T8070 T8083 arg1Of nature,obvious
R6679 T8073 T8071 arg2Of trigger,of
R6680 T8073 T8072 arg1Of trigger,the
R6681 T8073 T8074 arg1Of trigger,of
R6682 T8073 T8078 arg1Of trigger,in
R6683 T8077 T8074 arg2Of inflammation,of
R6684 T8077 T8075 arg1Of inflammation,the
R6685 T8077 T8076 arg1Of inflammation,severe
R6686 T8080 T8078 arg2Of mice,in
R6687 T8080 T8079 arg1Of mice,cpdm
R6688 T8081 T8059 arg1Of is,Since
R6689 T8081 T8068 arg1Of is,","
R6690 T8081 T8082 arg1Of is,not
R6691 T8083 T8081 arg2Of obvious,is
R6692 T8087 T8084 arg1Of factor,One
R6693 T8087 T8085 arg1Of factor,such
R6694 T8087 T8086 arg1Of factor,initiating
R6695 T8087 T8088 arg1Of factor,could
R6696 T8087 T8089 arg1Of factor,be
R6697 T8089 T8088 arg2Of be,could
R6698 T8091 T8092 arg1Of apoptotic,and/or
R6699 T8093 T8092 arg2Of necrotic,and/or
R6700 T8094 T8089 arg2Of cells,be
R6701 T8094 T8090 arg1Of cells,endogenous
R6702 T8094 T8091 arg1Of cells,apoptotic
R6703 T8094 T8093 arg1Of cells,necrotic
R6704 T8094 T8095 arg1Of cells,that
R6705 T8094 T8096 arg1Of cells,can
R6706 T8094 T8097 arg1Of cells,release
R6707 T8097 T8096 arg2Of release,can
R6708 T8100 T8097 arg2Of patterns,release
R6709 T8100 T8098 arg1Of patterns,danger-associated
R6710 T8100 T8099 arg1Of patterns,molecular
R6711 T8100 T8101 arg1Of patterns,(
R6712 T8100 T8105 arg1Of patterns,launch
R6713 T8100 T8107 arg1Of patterns,amplify
R6714 T8102 T8101 arg2Of DAMPs,(
R6715 T8103 T8101 arg3Of ),(
R6716 T8105 T8106 arg1Of launch,and
R6717 T8106 T8097 arg3Of and,release
R6718 T8106 T8104 arg1Of and,to
R6719 T8106 T8111 arg1Of and,[
R6720 T8107 T8106 arg2Of amplify,and
R6721 T8110 T8105 arg2Of response,launch
R6722 T8110 T8107 arg2Of response,amplify
R6723 T8110 T8108 arg1Of response,an
R6724 T8110 T8109 arg1Of response,inflammatory
R6725 T8112 T8111 arg2Of 32,[
R6726 T8113 T8111 arg3Of ],[
R6727 T8116 T8114 arg1Of inflammation,Such
R6728 T8116 T8115 arg1Of inflammation,‘sterile’
R6729 T8116 T8117 arg1Of inflammation,could
R6730 T8116 T8118 arg1Of inflammation,be
R6731 T8116 T8119 arg2Of inflammation,initiated
R6732 T8116 T8121 arg1Of inflammation,take
R6733 T8119 T8118 arg2Of initiated,be
R6734 T8119 T8120 arg1Of initiated,and
R6735 T8120 T8117 arg2Of and,could
R6736 T8120 T8132 arg1Of and,","
R6737 T8120 T8134 modOf and,causing
R6738 T8121 T8120 arg2Of take,and
R6739 T8121 T8123 arg1Of take,in
R6740 T8122 T8121 arg2Of place,take
R6741 T8125 T8126 arg1Of organs,and
R6742 T8126 T8123 arg2Of and,in
R6743 T8126 T8124 arg1Of and,all
R6744 T8126 T8128 arg2Of and,affected
R6745 T8127 T8126 arg2Of tissues,and
R6746 T8128 T8129 arg1Of affected,in
R6747 T8131 T8129 arg2Of mice,in
R6748 T8131 T8130 arg1Of mice,cpdm
R6749 T8134 T8133 arg1Of causing,thus
R6750 T8137 T8134 arg2Of disorders,causing
R6751 T8137 T8135 arg1Of disorders,multi-organ
R6752 T8137 T8136 arg1Of disorders,inflammatory
R6753 T8139 T8138 arg1Of hypothesis,This
R6754 T8139 T8140 arg1Of hypothesis,is
R6755 T8139 T8141 arg2Of hypothesis,supported
R6756 T8141 T8140 arg2Of supported,is
R6757 T8145 T8141 arg1Of studies,supported
R6758 T8145 T8142 arg2Of studies,by
R6759 T8145 T8143 arg1Of studies,several
R6760 T8145 T8144 arg1Of studies,recent
R6761 T8146 T8147 arg1Of Fibroblasts,of
R6762 T8146 T8150 arg1Of Fibroblasts,are
R6763 T8146 T8152 arg1Of Fibroblasts,sensitive
R6764 T8149 T8147 arg2Of mice,of
R6765 T8149 T8148 arg1Of mice,cpdm
R6766 T8150 T8157 arg1Of are,and
R6767 T8152 T8150 arg2Of sensitive,are
R6768 T8152 T8151 arg1Of sensitive,highly
R6769 T8152 T8153 arg1Of sensitive,to
R6770 T8156 T8153 arg2Of death,to
R6771 T8156 T8154 arg1Of death,TNFα-induced
R6772 T8156 T8155 arg1Of death,cell
R6773 T8160 T8158 arg1Of phenotype,the
R6774 T8160 T8159 arg1Of phenotype,cpdm
R6775 T8160 T8161 arg1Of phenotype,can
R6776 T8160 T8162 arg1Of phenotype,be
R6777 T8160 T8164 arg2Of phenotype,rescued
R6778 T8164 T8157 arg2Of rescued,and
R6779 T8164 T8161 arg2Of rescued,can
R6780 T8164 T8162 arg2Of rescued,be
R6781 T8164 T8163 arg1Of rescued,partially
R6782 T8164 T8172 arg1Of rescued,","
R6783 T8164 T8173 arg1Of rescued,[
R6784 T8164 T8176 arg1Of rescued,","
R6785 T8164 T8177 modOf rescued,suggesting
R6786 T8166 T8164 arg1Of deletion,rescued
R6787 T8166 T8165 arg2Of deletion,by
R6788 T8166 T8167 arg1Of deletion,of
R6789 T8168 T8167 arg2Of TNF,of
R6790 T8168 T8169 arg1Of TNF,[
R6791 T8170 T8169 arg2Of 7,[
R6792 T8171 T8169 arg3Of ],[
R6793 T8174 T8173 arg2Of 8,[
R6794 T8175 T8173 arg3Of ],[
R6795 T8179 T8180 arg1Of deficiency,of
R6796 T8179 T8182 arg1Of deficiency,compromises
R6797 T8181 T8180 arg2Of SHARPIN,of
R6798 T8182 T8177 arg2Of compromises,suggesting
R6799 T8182 T8178 arg1Of compromises,that
R6800 T8182 T8186 arg1Of compromises,in
R6801 T8185 T8182 arg2Of mechanisms,compromises
R6802 T8185 T8183 arg1Of mechanisms,the
R6803 T8185 T8184 arg1Of mechanisms,anti-apoptotic
R6804 T8188 T8186 arg2Of mice,in
R6805 T8188 T8187 arg1Of mice,cpdm
R6806 T8188 T8189 arg1Of mice,resulting
R6807 T8189 T8190 arg1Of resulting,in
R6808 T8194 T8190 arg2Of disease,in
R6809 T8194 T8191 arg1Of disease,cell
R6810 T8194 T8192 arg1Of disease,death-induced
R6811 T8194 T8193 arg1Of disease,inflammatory
R6812 T8195 T8196 arg1Of Apoptosis,of
R6813 T8195 T8198 arg1Of Apoptosis,is
R6814 T8197 T8196 arg2Of keratinocytes,of
R6815 T8198 T8209 arg1Of is,[
R6816 T8198 T8212 arg1Of is,and
R6817 T8201 T8198 arg2Of feature,is
R6818 T8201 T8199 arg1Of feature,a
R6819 T8201 T8200 arg1Of feature,prominent
R6820 T8201 T8202 arg1Of feature,of
R6821 T8201 T8206 arg1Of feature,in
R6822 T8205 T8202 arg2Of lesions,of
R6823 T8205 T8203 arg1Of lesions,the
R6824 T8205 T8204 arg1Of lesions,skin
R6825 T8208 T8206 arg2Of mice,in
R6826 T8208 T8207 arg1Of mice,cpdm
R6827 T8210 T8209 arg2Of 33,[
R6828 T8211 T8209 arg3Of ],[
R6829 T8212 T8220 arg1Of and,[
R6830 T8213 T8214 arg1Of this,is
R6831 T8213 T8215 arg2Of this,mediated
R6832 T8215 T8212 arg2Of mediated,and
R6833 T8215 T8214 arg2Of mediated,is
R6834 T8219 T8215 arg1Of pathways,mediated
R6835 T8219 T8216 arg2Of pathways,by
R6836 T8219 T8217 arg1Of pathways,caspase-dependent
R6837 T8219 T8218 arg1Of pathways,mitochondrial
R6838 T8221 T8220 arg2Of 34,[
R6839 T8222 T8220 arg3Of ],[
R6840 T8322 T8319 arg1Of inflammation,the
R6841 T8224 T8225 arg1Of induced,and/or
R6842 T8226 T8225 arg2Of intrinsic,and/or
R6843 T8228 T8223 arg1Of cells,These
R6844 T8228 T8224 arg1Of cells,induced
R6845 T8228 T8226 arg1Of cells,intrinsic
R6846 T8228 T8227 arg1Of cells,apoptotic
R6847 T8228 T8229 arg1Of cells,can
R6848 T8228 T8230 arg1Of cells,release
R6849 T8230 T8229 arg2Of release,can
R6850 T8230 T8264 arg1Of release,","
R6851 T8230 T8265 arg1Of release,[
R6852 T8322 T8320 arg1Of inflammation,Th2-biased
R6853 T8232 T8230 arg2Of types,release
R6854 T8232 T8231 arg1Of types,various
R6855 T8232 T8233 arg1Of types,of
R6856 T8322 T8321 arg1Of inflammation,systemic
R6857 T8234 T8233 arg2Of DAMPs,of
R6858 T8234 T8235 arg1Of DAMPs,that
R6859 T8234 T8236 arg1Of DAMPs,exert
R6860 T8234 T8241 arg1Of DAMPs,activating
R6861 T8234 T8254 arg1Of DAMPs,","
R6862 T8234 T8256 arg1Of DAMPs,as
R6863 T8322 T8323 arg1Of inflammation,in
R6864 T8236 T8240 arg1Of exert,by
R6865 T8236 T8250 arg1Of exert,","
R6866 T8236 T8251 arg1Of exert,[
R6867 T8322 T8326 arg1Of inflammation,is
R6868 T8322 T8327 arg2Of inflammation,caused
R6869 T8239 T8236 arg2Of properties,exert
R6870 T8239 T8237 arg1Of properties,their
R6871 T8239 T8238 arg1Of properties,pro-inflammatory
R6872 T8325 T8323 arg2Of mice,in
R6873 T8241 T8240 arg2Of activating,by
R6874 T8241 T8243 arg1Of activating,through
R6875 T8242 T8241 arg2Of DC,activating
R6876 T8325 T8324 arg1Of mice,cpdm
R6877 T8246 T8243 arg2Of receptors,through
R6878 T8246 T8244 arg1Of receptors,pattern
R6879 T8246 T8245 arg1Of receptors,recognition
R6880 T8246 T8247 arg1Of receptors,[
R6881 T8248 T8247 arg2Of 32,[
R6882 T8327 T8317 arg2Of caused,suggests
R6883 T8249 T8247 arg3Of ],[
R6884 T8252 T8251 arg2Of 35,[
R6885 T8327 T8318 arg1Of caused,that
R6886 T8253 T8251 arg3Of ],[
R6887 T8327 T8326 arg2Of caused,is
R6888 T8331 T8327 arg1Of production,caused
R6889 T8256 T8255 arg1Of as,such
R6890 T8257 T8256 arg2Of HMGB1,as
R6891 T8257 T8258 arg2Of HMGB1,recognized
R6892 T8260 T8258 arg1Of TLR2/4,recognized
R6893 T8260 T8259 arg2Of TLR2/4,by
R6894 T8260 T8261 arg1Of TLR2/4,[
R6895 T8262 T8261 arg2Of 36,[
R6896 T8331 T8328 arg2Of production,by
R6897 T8263 T8261 arg3Of ],[
R6898 T8266 T8265 arg2Of 37,[
R6899 T8331 T8329 arg2Of production,reduced
R6900 T8267 T8265 arg3Of ],[
R6901 T8268 T8269 arg1Of Consistent,with
R6902 T8331 T8330 arg1Of production,IL12P70
R6903 T8331 T8332 arg1Of production,from
R6904 T8333 T8332 arg2Of DC,from
R6905 T8274 T8269 arg2Of response,with
R6906 T8274 T8270 arg1Of response,the
R6907 T8274 T8271 arg1Of response,impaired
R6908 T8274 T8272 arg1Of response,Th1
R6909 T8274 T8273 arg1Of response,immune
R6910 T8274 T8275 arg1Of response,in
R6911 T8335 T8334 arg1Of importance,The
R6912 T8277 T8275 arg2Of mice,in
R6913 T8277 T8276 arg1Of mice,cpdm
R6914 T8277 T8278 arg1Of mice,[
R6915 T8279 T8278 arg2Of 5,[
R6916 T8280 T8278 arg3Of ],[
R6917 T8335 T8336 arg1Of importance,of
R6918 T8335 T8338 arg1Of importance,in
R6919 T8335 T8345 arg1Of importance,in
R6920 T8283 T8282 arg1Of BMDC,stimulated
R6921 T8283 T8285 arg1Of BMDC,polarized
R6922 T8283 T8291 arg1Of BMDC,supported
R6923 T8335 T8347 arg1Of importance,was
R6924 T8285 T8289 arg1Of polarized,but
R6925 T8335 T8349 arg2Of importance,demonstrated
R6926 T8337 T8336 arg2Of IL12P70,of
R6927 T8287 T8285 arg2Of differentiation,polarized
R6928 T8287 T8286 arg1Of differentiation,Th1
R6929 T8289 T8268 arg1Of but,Consistent
R6930 T8289 T8281 arg1Of but,","
R6931 T8289 T8284 arg1Of but,weakly
R6932 T8289 T8288 arg1Of but,","
R6933 T8291 T8289 arg2Of supported,but
R6934 T8291 T8290 arg1Of supported,strongly
R6935 T8339 T8338 arg2Of regulating,in
R6936 T8293 T8291 arg2Of development,supported
R6937 T8293 T8292 arg1Of development,the
R6938 T8293 T8294 arg1Of development,of
R6939 T8297 T8294 arg2Of cells,of
R6940 T8297 T8295 arg1Of cells,Th2
R6941 T8297 T8296 arg1Of cells,effector
R6942 T8298 T8299 arg1Of Combined,with
R6943 T8340 T8341 arg1Of Th1,and
R6944 T8342 T8341 arg2Of Th2,and
R6945 T8302 T8299 arg2Of effect,with
R6946 T8302 T8300 arg1Of effect,the
R6947 T8302 T8301 arg1Of effect,dramatic
R6948 T8302 T8303 arg1Of effect,of
R6949 T8302 T8306 arg1Of effect,on
R6950 T8305 T8303 arg2Of treatment,of
R6951 T8305 T8304 arg1Of treatment,IL12
R6952 T8308 T8306 arg2Of phenotype,on
R6953 T8308 T8307 arg1Of phenotype,the
R6954 T8308 T8309 arg1Of phenotype,of
R6955 T8344 T8339 arg2Of responses,regulating
R6956 T8311 T8309 arg2Of mice,of
R6957 T8311 T8310 arg1Of mice,these
R6958 T8311 T8312 arg1Of mice,[
R6959 T8313 T8312 arg2Of 5,[
R6960 T8314 T8312 arg3Of ],[
R6961 T8344 T8340 arg1Of responses,Th1
R6962 T8316 T8298 arg2Of this,Combined
R6963 T8316 T8317 arg1Of this,suggests
R6964 T8344 T8342 arg1Of responses,Th2
R6965 T8317 T8298 modOf suggests,Combined
R6966 T8317 T8315 arg1Of suggests,","
R6967 T8344 T8343 arg1Of responses,immune
R6968 T8346 T8345 arg2Of mice,in
R6969 T8349 T8347 arg2Of demonstrated,was
R6970 T8416 T8405 arg1Of C,NF-κB
R6971 T8416 T8417 arg1Of C,stimulated
R6972 T8349 T8348 arg1Of demonstrated,clearly
R6973 T8417 T8420 arg1Of stimulated,compared
R6974 T8349 T8350 arg1Of demonstrated,in
R6975 T8417 T8424 arg1Of stimulated,","
R6976 T8417 T8425 arg1Of stimulated,while
R6977 T8349 T8363 arg1Of demonstrated,through
R6978 T8419 T8417 arg2Of BMDC,stimulated
R6979 T8419 T8418 arg1Of BMDC,cpdm
R6980 T8349 T8369 arg1Of demonstrated,[
R6981 T8421 T8420 arg2Of to,compared
R6982 T8349 T8372 arg1Of demonstrated,–
R6983 T8349 T8373 arg1Of demonstrated,[
R6984 T8423 T8421 arg2Of type,to
R6985 T8423 T8422 arg1Of type,wild
R6986 T8350 T8362 arg1Of in,and
R6987 T8426 T8427 arg1Of activation,of
R6988 T8426 T8434 arg1Of activation,was
R6989 T8426 T8437 arg1Of activation,indicating
R6990 T8351 T8352 arg1Of IL12P35-,and
R6991 T8428 T8429 arg1Of TBK1/IRF3,","
R6992 T8429 T8432 arg1Of ",",or
R6993 T8430 T8429 arg2Of ERK1/2,","
R6994 T8353 T8352 arg2Of IL12P40-deficient,and
R6995 T8432 T8427 arg2Of or,of
R6996 T8432 T8431 arg1Of or,","
R6997 T8433 T8432 arg2Of p38,or
R6998 T8437 T8425 arg2Of indicating,while
R6999 T8437 T8434 arg2Of indicating,was
R7000 T8437 T8435 arg1Of indicating,not
R7001 T8437 T8436 arg1Of indicating,","
R7002 T8354 T8350 arg2Of mice,in
R7003 T8441 T8439 arg2Of signaling,disrupted
R7004 T8441 T8440 arg1Of signaling,NF-κB
R7005 T8441 T8442 arg1Of signaling,in
R7006 T8441 T8445 arg1Of signaling,is
R7007 T8441 T8446 arg1Of signaling,responsible
R7008 T8354 T8351 arg1Of mice,IL12P35-
R7009 T8444 T8442 arg2Of DC,in
R7010 T8444 T8443 arg1Of DC,cpdm
R7011 T8445 T8437 arg2Of is,indicating
R7012 T8445 T8438 arg1Of is,that
R7013 T8354 T8353 arg1Of mice,IL12P40-deficient
R7014 T8446 T8445 arg2Of responsible,is
R7015 T8446 T8447 arg1Of responsible,for
R7016 T8354 T8355 arg1Of mice,[
R7017 T8354 T8358 arg1Of mice,","
R7018 T8354 T8359 arg1Of mice,[
R7019 T8356 T8355 arg2Of 38,[
R7020 T8451 T8447 arg2Of expression,for
R7021 T8451 T8448 arg1Of expression,the
R7022 T8451 T8449 arg1Of expression,defective
R7023 T8451 T8450 arg1Of expression,cytokine
R7024 T8453 T8452 arg1Of results,These
R7025 T8453 T8454 arg1Of results,seem
R7026 T8453 T8456 arg1Of results,contradict
R7027 T8357 T8355 arg3Of ],[
R7028 T8456 T8454 arg2Of contradict,seem
R7029 T8456 T8455 arg1Of contradict,to
R7030 T8360 T8359 arg2Of 39,[
R7031 T8459 T8456 arg2Of study,contradict
R7032 T8459 T8457 arg1Of study,a
R7033 T8459 T8458 arg1Of study,recent
R7034 T8459 T8460 arg1Of study,that
R7035 T8459 T8461 arg1Of study,found
R7036 T8461 T8473 arg1Of found,[
R7037 T8361 T8359 arg3Of ],[
R7038 T8463 T8461 arg2Of levels,found
R7039 T8463 T8462 arg2Of levels,increased
R7040 T8463 T8464 arg1Of levels,of
R7041 T8363 T8362 arg2Of through,and
R7042 T8466 T8465 arg1Of activation,NF-κB
R7043 T8466 T8467 arg1Of activation,and
R7044 T8467 T8464 arg2Of and,of
R7045 T8467 T8470 arg1Of and,in
R7046 T8469 T8467 arg2Of transcription,and
R7047 T8469 T8468 arg1Of transcription,IL1
R7048 T8365 T8363 arg2Of studies,through
R7049 T8472 T8470 arg2Of mice,in
R7050 T8472 T8471 arg1Of mice,cpdm
R7051 T8474 T8473 arg2Of 43,[
R7052 T8475 T8473 arg3Of ],[
R7053 T8477 T8476 arg1Of difference,This
R7054 T8477 T8478 arg1Of difference,can
R7055 T8477 T8480 arg1Of difference,be
R7056 T8477 T8481 arg2Of difference,attributed
R7057 T8477 T8494 arg1Of difference,may
R7058 T8477 T8495 arg1Of difference,point
R7059 T8365 T8364 arg1Of studies,clinical
R7060 T8365 T8366 arg1Of studies,in
R7061 T8481 T8478 arg2Of attributed,can
R7062 T8481 T8479 arg1Of attributed,probably
R7063 T8481 T8480 arg2Of attributed,be
R7064 T8481 T8482 arg1Of attributed,to
R7065 T8481 T8493 arg1Of attributed,and
R7066 T8368 T8366 arg2Of patients,in
R7067 T8485 T8486 arg1Of cells,and
R7068 T8486 T8482 arg2Of and,to
R7069 T8486 T8483 arg1Of and,the
R7070 T8486 T8484 arg1Of and,different
R7071 T8486 T8488 arg2Of and,used
R7072 T8487 T8486 arg2Of tissues,and
R7073 T8488 T8489 arg1Of used,in
R7074 T8368 T8367 arg1Of patients,human
R7075 T8370 T8369 arg2Of 40,[
R7076 T8491 T8489 arg2Of studies,in
R7077 T8491 T8490 arg1Of studies,these
R7078 T8493 T8492 arg1Of and,","
R7079 T8371 T8369 arg3Of ],[
R7080 T8495 T8493 arg2Of point,and
R7081 T8495 T8494 arg2Of point,may
R7082 T8495 T8496 arg1Of point,to
R7083 T8374 T8373 arg2Of 42,[
R7084 T8497 T8498 arg1Of cell-,and
R7085 T8499 T8498 arg2Of tissue-,and
R7086 T8375 T8373 arg3Of ],[
R7087 T8502 T8496 arg2Of functions,to
R7088 T8502 T8497 arg1Of functions,cell-
R7089 T8502 T8499 arg1Of functions,tissue-
R7090 T8502 T8500 arg1Of functions,type
R7091 T8502 T8501 arg1Of functions,specific
R7092 T8502 T8503 arg1Of functions,of
R7093 T8504 T8503 arg2Of SHARPIN,of
R7094 T8505 T8506 arg1Of This,is
R7095 T8505 T8507 arg1Of This,consistent
R7096 T8376 T8377 arg1Of NF-κB,","
R7097 T8377 T8380 arg1Of ",",and
R7098 T8506 T8517 arg1Of is,[
R7099 T8507 T8506 arg2Of consistent,is
R7100 T8507 T8508 arg1Of consistent,with
R7101 T8378 T8377 arg2Of TBK/IRF3,","
R7102 T8510 T8508 arg2Of reports,with
R7103 T8510 T8509 arg1Of reports,recent
R7104 T8510 T8511 arg1Of reports,of
R7105 T8380 T8379 arg1Of and,","
R7106 T8380 T8383 arg1Of and,are
R7107 T8382 T8380 arg2Of signaling,and
R7108 T8382 T8381 arg1Of signaling,MAPK
R7109 T8383 T8392 arg1Of are,:
R7110 T8513 T8511 arg2Of effects,of
R7111 T8513 T8512 arg1Of effects,tissue-specific
R7112 T8513 T8514 arg1Of effects,of
R7113 T8385 T8383 arg2Of pathways,are
R7114 T8516 T8514 arg2Of signaling,of
R7115 T8516 T8515 arg1Of signaling,NF-κB
R7116 T8518 T8517 arg2Of 44,[
R7117 T8519 T8517 arg3Of ],[
R7118 T8385 T8384 arg1Of pathways,important
R7119 T8385 T8386 arg2Of pathways,activated
R7120 T8521 T8520 arg1Of activation,Ubiquitous
R7121 T8521 T8522 arg1Of activation,of
R7122 T8521 T8524 arg1Of activation,by
R7123 T8521 T8535 arg1Of activation,results
R7124 T8521 T8540 arg1Of activation,consistent
R7125 T8388 T8389 arg1Of LPS,or
R7126 T8523 T8522 arg2Of NF-κB,of
R7127 T8525 T8524 arg2Of removing,by
R7128 T8526 T8525 arg2Of inhibitors,removing
R7129 T8526 T8528 arg1Of inhibitors,as
R7130 T8389 T8386 arg1Of or,activated
R7131 T8528 T8527 arg1Of as,such
R7132 T8529 T8530 arg1Of A20,and
R7133 T8530 T8528 arg2Of and,as
R7134 T8530 T8532 arg1Of and,through
R7135 T8389 T8387 arg2Of or,by
R7136 T8531 T8530 arg2Of ITCH,and
R7137 T8391 T8389 arg2Of I,or
R7138 T8534 T8532 arg2Of manipulation,through
R7139 T8534 T8533 arg1Of manipulation,genetic
R7140 T8535 T8536 arg1Of results,in
R7141 T8535 T8539 arg1Of results,","
R7142 T8535 T8540 modOf results,consistent
R7143 T8391 T8390 arg1Of I,poly
R7144 T8535 T8555 arg1Of results,","
R7145 T8535 T8556 arg1Of results,[
R7146 T8393 T8394 arg1Of C,and
R7147 T8538 T8536 arg2Of inflammation,in
R7148 T8538 T8537 arg1Of inflammation,widespread
R7149 T8540 T8541 arg1Of consistent,with
R7150 T8394 T8396 arg1Of and,of
R7151 T8543 T8541 arg2Of role,with
R7152 T8543 T8542 arg1Of role,the
R7153 T8543 T8544 arg1Of role,of
R7154 T8543 T8546 arg1Of role,in
R7155 T8545 T8544 arg2Of NF-κB,of
R7156 T8394 T8399 arg1Of and,may
R7157 T8394 T8400 arg1Of and,lead
R7158 T8548 T8546 arg2Of production,in
R7159 T8548 T8547 arg1Of production,the
R7160 T8548 T8549 arg1Of production,of
R7161 T8395 T8394 arg2Of disruption,and
R7162 T8551 T8549 arg2Of mediators,of
R7163 T8551 T8550 arg1Of mediators,pro-inflammatory
R7164 T8551 T8552 arg1Of mediators,[
R7165 T8398 T8396 arg2Of pathway,of
R7166 T8553 T8552 arg2Of 45,[
R7167 T8554 T8552 arg3Of ],[
R7168 T8398 T8397 arg1Of pathway,either
R7169 T8557 T8556 arg2Of 46,[
R7170 T8400 T8392 arg2Of lead,:
R7171 T8558 T8556 arg3Of ],[
R7172 T8400 T8399 arg2Of lead,may
R7173 T8400 T8401 arg1Of lead,to
R7174 T8562 T8561 arg1Of inhibition,selective
R7175 T8562 T8563 arg1Of inhibition,of
R7176 T8562 T8566 arg1Of inhibition,in
R7177 T8562 T8577 arg1Of inhibition,results
R7178 T8565 T8563 arg2Of activation,of
R7179 T8565 T8564 arg1Of activation,NF-κB
R7180 T8404 T8401 arg2Of expression,to
R7181 T8568 T8566 arg2Of cells,in
R7182 T8568 T8567 arg1Of cells,parenchymal
R7183 T8568 T8569 arg1Of cells,of
R7184 T8571 T8572 arg1Of skin,","
R7185 T8572 T8575 arg1Of ",",and
R7186 T8404 T8402 arg2Of expression,decreased
R7187 T8573 T8572 arg2Of liver,","
R7188 T8404 T8403 arg1Of expression,cytokine
R7189 T8575 T8569 arg2Of and,of
R7190 T8575 T8570 arg1Of and,the
R7191 T8575 T8574 arg1Of and,","
R7192 T8576 T8575 arg2Of intestine,and
R7193 T8405 T8407 modOf NF-κB,was
R7194 T8577 T8559 arg1Of results,However
R7195 T8577 T8560 arg1Of results,","
R7196 T8577 T8578 arg1Of results,in
R7197 T8577 T8590 arg1Of results,[
R7198 T8580 T8578 arg2Of inflammation,in
R7199 T8580 T8579 arg1Of inflammation,chronic
R7200 T8580 T8581 arg2Of inflammation,driven
R7201 T8580 T8589 arg1Of inflammation,–
R7202 T8581 T8586 arg1Of driven,[
R7203 T8405 T8415 arg1Of NF-κB,:
R7204 T8585 T8581 arg1Of leukocytes,driven
R7205 T8585 T8582 arg2Of leukocytes,by
R7206 T8585 T8583 arg1Of leukocytes,NF-κB
R7207 T8585 T8584 arg1Of leukocytes,competent
R7208 T8406 T8407 arg1Of activation,was
R7209 T8587 T8586 arg2Of 47,[
R7210 T8588 T8586 arg3Of ],[
R7211 T8406 T8409 arg2Of activation,inhibited
R7212 T8409 T8407 arg2Of inhibited,was
R7213 T8591 T8590 arg2Of 50,[
R7214 T8592 T8590 arg3Of ],[
R7215 T8593 T8594 arg1Of This,indicates
R7216 T8409 T8408 arg1Of inhibited,selectively
R7217 T8409 T8410 arg1Of inhibited,in
R7218 T8597 T8596 arg1Of balance,a
R7219 T8597 T8598 arg1Of balance,between
R7220 T8597 T8613 arg1Of balance,is
R7221 T8597 T8614 arg1Of balance,critical
R7222 T8411 T8412 arg1Of LPS,and
R7223 T8601 T8599 arg1Of role,the
R7224 T8601 T8600 arg1Of role,pro-inflammatory
R7225 T8601 T8602 arg1Of role,of
R7226 T8601 T8604 arg1Of role,in
R7227 T8601 T8606 arg1Of role,and
R7228 T8603 T8602 arg2Of NF-κB,of
R7229 T8412 T8410 arg2Of and,in
R7230 T8605 T8604 arg2Of leukocytes,in
R7231 T8606 T8598 arg2Of and,between
R7232 T8414 T8412 arg2Of I,and
R7233 T8609 T8606 arg2Of role,and
R7234 T8609 T8607 arg1Of role,the
R7235 T8609 T8608 arg1Of role,anti-inflammatory
R7236 T8609 T8610 arg1Of role,in
R7237 T8414 T8413 arg1Of I,poly
R7238 T8709 T8707 arg1Of pathway,The
R7239 T8709 T8708 arg1Of pathway,non-canonical
R7240 T8612 T8610 arg2Of cells,in
R7241 T8612 T8611 arg1Of cells,parenchymal
R7242 T8613 T8594 arg2Of is,indicates
R7243 T8613 T8595 arg1Of is,that
R7244 T8709 T8710 arg1Of pathway,(
R7245 T8614 T8613 arg2Of critical,is
R7246 T8614 T8615 arg1Of critical,in
R7247 T8709 T8717 arg1Of pathway,appears
R7248 T8709 T8719 arg1Of pathway,be
R7249 T8617 T8615 arg2Of maintenance,in
R7250 T8617 T8616 arg1Of maintenance,the
R7251 T8617 T8618 arg1Of maintenance,of
R7252 T8709 T8720 arg1Of pathway,intact
R7253 T8712 T8710 arg2Of processing,(
R7254 T8620 T8618 arg2Of homeostasis,of
R7255 T8620 T8619 arg1Of homeostasis,tissue
R7256 T8621 T8622 arg1Of Experiments,with
R7257 T8621 T8636 arg1Of Experiments,will
R7258 T8621 T8637 arg1Of Experiments,help
R7259 T8621 T8639 arg1Of Experiments,elucidate
R7260 T8623 T8622 arg2Of mice,with
R7261 T8623 T8624 arg1Of mice,with
R7262 T8625 T8626 arg1Of cell-,and
R7263 T8712 T8711 arg1Of processing,p100
R7264 T8627 T8626 arg2Of tissue-specific,and
R7265 T8712 T8713 modOf processing,to
R7266 T8628 T8624 arg2Of deletion,with
R7267 T8628 T8625 arg1Of deletion,cell-
R7268 T8628 T8627 arg1Of deletion,tissue-specific
R7269 T8628 T8629 arg1Of deletion,of
R7270 T8714 T8713 arg1Of produce,to
R7271 T8630 T8629 arg2Of Sharpin,of
R7272 T8630 T8631 arg1Of Sharpin,","
R7273 T8630 T8633 arg1Of Sharpin,under
R7274 T8633 T8632 arg1Of under,currently
R7275 T8715 T8714 arg2Of p52,produce
R7276 T8634 T8633 arg2Of way,under
R7277 T8716 T8710 arg3Of ),(
R7278 T8637 T8635 arg1Of help,","
R7279 T8637 T8636 arg2Of help,will
R7280 T8639 T8637 arg2Of elucidate,help
R7281 T8639 T8638 arg1Of elucidate,to
R7282 T8719 T8717 arg2Of be,appears
R7283 T8641 T8639 arg2Of role,elucidate
R7284 T8641 T8640 arg1Of role,the
R7285 T8641 T8642 arg1Of role,of
R7286 T8641 T8644 arg1Of role,in
R7287 T8643 T8642 arg2Of SHARPIN,of
R7288 T8645 T8644 arg2Of inflammation,in
R7289 T8719 T8718 arg1Of be,to
R7290 T8719 T8731 modOf be,suggesting
R7291 T8720 T8719 arg2Of intact,be
R7292 T8649 T8646 arg2Of activation,Despite
R7293 T8649 T8647 arg1Of activation,defective
R7294 T8649 T8648 arg1Of activation,NF-κB
R7295 T8649 T8650 arg1Of activation,in
R7296 T8650 T8651 arg1Of in,the
R7297 T8650 T8653 arg1Of in,of
R7298 T8652 T8650 arg2Of absence,in
R7299 T8720 T8721 arg1Of intact,in
R7300 T8655 T8650 arg3Of expression,in
R7301 T8655 T8654 arg1Of expression,Sharpin
R7302 T8723 T8721 arg2Of cells,in
R7303 T8657 T8658 arg1Of there,was
R7304 T8658 T8646 arg1Of was,Despite
R7305 T8658 T8656 arg1Of was,","
R7306 T8658 T8662 arg1Of was,in
R7307 T8661 T8658 arg2Of change,was
R7308 T8661 T8659 arg1Of change,no
R7309 T8661 T8660 arg1Of change,significant
R7310 T8723 T8722 arg1Of cells,SHARPIN-deficient
R7311 T8723 T8724 arg1Of cells,[
R7312 T8665 T8663 arg1Of populations,splenic
R7313 T8665 T8664 arg1Of populations,DC
R7314 T8665 T8666 arg1Of populations,or
R7315 T8666 T8662 arg2Of or,in
R7316 T8723 T8727 arg1Of cells,","
R7317 T8667 T8666 arg2Of expression,or
R7318 T8667 T8668 arg1Of expression,of
R7319 T8667 T8671 arg1Of expression,on
R7320 T8723 T8728 arg1Of cells,[
R7321 T8725 T8724 arg2Of 7,[
R7322 T8670 T8668 arg2Of molecules,of
R7323 T8670 T8669 arg1Of molecules,co-stimulatory
R7324 T8672 T8671 arg2Of BMDC,on
R7325 T8726 T8724 arg3Of ],[
R7326 T8675 T8673 arg1Of subunits,Different
R7327 T8675 T8674 arg1Of subunits,NF-κB
R7328 T8675 T8676 arg2Of subunits,involved
R7329 T8675 T8688 arg1Of subunits,have
R7330 T8675 T8692 arg1Of subunits,control
R7331 T8729 T8728 arg2Of 9,[
R7332 T8676 T8677 arg1Of involved,in
R7333 T8679 T8680 arg1Of canonical,and
R7334 T8730 T8728 arg3Of ],[
R7335 T8681 T8680 arg2Of non-canonical,and
R7336 T8682 T8677 arg2Of branches,in
R7337 T8682 T8678 arg1Of branches,the
R7338 T8682 T8679 arg1Of branches,canonical
R7339 T8682 T8681 arg1Of branches,non-canonical
R7340 T8682 T8683 arg1Of branches,of
R7341 T8736 T8733 arg1Of p52/RELB,the
R7342 T8687 T8683 arg2Of pathway,of
R7343 T8687 T8684 arg1Of pathway,the
R7344 T8687 T8685 arg1Of pathway,NF-κB
R7345 T8687 T8686 arg1Of pathway,signaling
R7346 T8688 T8691 modOf have,to
R7347 T8688 T8703 arg1Of have,","
R7348 T8688 T8704 arg1Of have,[
R7349 T8690 T8688 arg2Of functions,have
R7350 T8690 T8689 arg1Of functions,distinct
R7351 T8692 T8691 arg1Of control,to
R7352 T8694 T8692 arg2Of aspects,control
R7353 T8694 T8693 arg1Of aspects,specific
R7354 T8694 T8695 arg1Of aspects,of
R7355 T8736 T8734 arg1Of p52/RELB,NF-κB
R7356 T8697 T8696 arg1Of development,DC
R7357 T8697 T8698 arg1Of development,and
R7358 T8698 T8695 arg2Of and,of
R7359 T8736 T8735 arg1Of p52/RELB,heterodimer
R7360 T8699 T8698 arg2Of function,and
R7361 T8699 T8700 arg1Of function,[
R7362 T8736 T8737 arg1Of p52/RELB,is
R7363 T8701 T8700 arg2Of 51,[
R7364 T8736 T8738 arg1Of p52/RELB,sufficient
R7365 T8702 T8700 arg3Of ],[
R7366 T8737 T8731 arg2Of is,suggesting
R7367 T8737 T8732 arg1Of is,that
R7368 T8705 T8704 arg2Of 52,[
R7369 T8706 T8704 arg3Of ],[
R7370 T8737 T8739 modOf is,to
R7371 T8738 T8737 arg2Of sufficient,is
R7372 T8740 T8739 arg1Of maintain,to
R7373 T8743 T8740 arg2Of regulation,maintain
R7374 T8804 T8802 arg1Of activation,defective
R7375 T8804 T8803 arg1Of activation,NF-κB
R7376 T8804 T8805 arg1Of activation,is
R7377 T8805 T8800 arg2Of is,suggesting
R7378 T8805 T8801 arg1Of is,that
R7379 T8805 T8806 arg1Of is,not
R7380 T8808 T8805 arg2Of result,is
R7381 T8808 T8807 arg1Of result,a
R7382 T8808 T8809 arg1Of result,of
R7383 T8743 T8741 arg1Of regulation,the
R7384 T8743 T8742 arg1Of regulation,normal
R7385 T8812 T8809 arg2Of expression,of
R7386 T8812 T8810 arg1Of expression,differential
R7387 T8812 T8811 arg1Of expression,TLR
R7388 T8812 T8813 arg1Of expression,on
R7389 T8743 T8744 arg1Of regulation,of
R7390 T8746 T8747 arg1Of homeostasis,and
R7391 T8815 T8813 arg2Of cells,on
R7392 T8815 T8814 arg1Of cells,target
R7393 T8816 T8817 arg1Of LPS,engages
R7394 T8817 T8819 modOf engages,to
R7395 T8817 T8826 arg1Of engages,whereas
R7396 T8818 T8817 arg2Of TLR4,engages
R7397 T8820 T8819 arg1Of activate,to
R7398 T8747 T8744 arg2Of and,of
R7399 T8821 T8822 arg1Of MYD88-dependent,and
R7400 T8747 T8745 arg1Of and,DC
R7401 T8823 T8822 arg2Of TRIF-dependent,and
R7402 T8824 T8820 arg2Of pathways,activate
R7403 T8824 T8821 arg1Of pathways,MYD88-dependent
R7404 T8824 T8823 arg1Of pathways,TRIF-dependent
R7405 T8826 T8825 arg1Of whereas,","
R7406 T8827 T8828 arg2Of TLR3,stimulated
R7407 T8827 T8835 arg1Of TLR3,triggers
R7408 T8748 T8747 arg2Of maturation,and
R7409 T8831 T8830 arg1Of I,poly
R7410 T8831 T8832 arg1Of I,:
R7411 T8751 T8749 arg1Of basis,The
R7412 T8833 T8828 arg1Of C,stimulated
R7413 T8833 T8829 arg2Of C,by
R7414 T8833 T8831 arg1Of C,I
R7415 T8835 T8826 arg2Of triggers,whereas
R7416 T8835 T8834 arg1Of triggers,only
R7417 T8837 T8835 arg2Of signaling,triggers
R7418 T8837 T8836 arg1Of signaling,TRIF-dependent
R7419 T8837 T8838 arg1Of signaling,[
R7420 T8751 T8750 arg1Of basis,molecular
R7421 T8751 T8752 arg2Of basis,by
R7422 T8751 T8753 arg1Of basis,which
R7423 T8751 T8763 arg1Of basis,remains
R7424 T8839 T8838 arg2Of 53,[
R7425 T8751 T8765 arg1Of basis,be
R7426 T8840 T8838 arg3Of ],[
R7427 T8751 T8766 arg2Of basis,determined
R7428 T8756 T8754 arg1Of mutation,the
R7429 T8844 T8841 arg1Of activation,The
R7430 T8844 T8842 arg1Of activation,defective
R7431 T8844 T8843 arg1Of activation,NF-κB
R7432 T8844 T8845 arg1Of activation,by
R7433 T8844 T8848 arg1Of activation,suggests
R7434 T8847 T8845 arg2Of stimuli,by
R7435 T8847 T8846 arg1Of stimuli,both
R7436 T8756 T8755 arg1Of mutation,Sharpin
R7437 T8852 T8850 arg1Of mutation,the
R7438 T8852 T8851 arg1Of mutation,Sharpin
R7439 T8852 T8853 arg1Of mutation,interferes
R7440 T8756 T8757 arg1Of mutation,causes
R7441 T8853 T8848 arg2Of interferes,suggests
R7442 T8853 T8849 arg1Of interferes,that
R7443 T8853 T8854 arg1Of interferes,with
R7444 T8757 T8752 arg1Of causes,by
R7445 T8857 T8858 arg1Of adaptors,or
R7446 T8760 T8757 arg2Of activation,causes
R7447 T8858 T8854 arg2Of or,with
R7448 T8858 T8855 arg1Of or,the
R7449 T8858 T8856 arg1Of or,protein
R7450 T8858 T8860 arg2Of or,shared
R7451 T8859 T8858 arg2Of kinases,or
R7452 T8864 T8860 arg1Of pathways,shared
R7453 T8864 T8861 arg2Of pathways,by
R7454 T8864 T8862 arg1Of pathways,both
R7455 T8864 T8863 arg1Of pathways,signaling
R7456 T8864 T8865 arg1Of pathways,","
R7457 T8864 T8867 arg1Of pathways,as
R7458 T8867 T8866 arg1Of as,such
R7459 T8868 T8869 arg1Of RIP1,and
R7460 T8760 T8758 arg2Of activation,reduced
R7461 T8869 T8867 arg2Of and,as
R7462 T8760 T8759 arg1Of activation,NF-κB
R7463 T8760 T8761 arg1Of activation,in
R7464 T8762 T8761 arg2Of BMDC,in
R7465 T8869 T8871 arg1Of and,[
R7466 T8766 T8763 arg2Of determined,remains
R7467 T8870 T8869 arg2Of TRAF6,and
R7468 T8872 T8871 arg2Of 18,[
R7469 T8873 T8871 arg3Of ],[
R7470 T8766 T8764 arg1Of determined,to
R7471 T8875 T8874 arg1Of studies,Recent
R7472 T8875 T8876 arg1Of studies,demonstrated
R7473 T8766 T8765 arg2Of determined,be
R7474 T8767 T8768 arg1Of LPS,and
R7475 T8878 T8879 arg1Of SHARPIN,interacts
R7476 T8879 T8876 arg2Of interacts,demonstrated
R7477 T8879 T8877 arg1Of interacts,that
R7478 T8879 T8880 arg1Of interacts,with
R7479 T8881 T8880 arg2Of HOIP,with
R7480 T8881 T8882 modOf HOIP,to
R7481 T8768 T8771 arg1Of and,:
R7482 T8883 T8882 arg1Of form,to
R7483 T8884 T8883 arg2Of LUBAC,form
R7484 T8884 T8885 arg1Of LUBAC,that
R7485 T8884 T8886 arg1Of LUBAC,exerts
R7486 T8770 T8768 arg2Of I,and
R7487 T8889 T8886 arg2Of activity,exerts
R7488 T8889 T8887 arg1Of activity,its
R7489 T8889 T8888 arg1Of activity,linear-ubiquitin-chain-ligase
R7490 T8889 T8890 arg1Of activity,on
R7491 T8770 T8769 arg1Of I,poly
R7492 T8772 T8767 arg1Of C,LPS
R7493 T8894 T8891 arg1Of RIP1,NF-κB
R7494 T8894 T8892 arg1Of RIP1,signaling
R7495 T8894 T8893 arg1Of RIP1,players
R7496 T8894 T8895 arg1Of RIP1,and
R7497 T8895 T8890 arg2Of and,on
R7498 T8895 T8900 arg1Of and,","
R7499 T8896 T8895 arg2Of NEMO,and
R7500 T8896 T8897 arg1Of NEMO,[
R7501 T8772 T8770 arg1Of C,I
R7502 T8898 T8897 arg2Of 7,[
R7503 T8899 T8897 arg3Of ],[
R7504 T8772 T8773 arg2Of C,used
R7505 T8772 T8775 arg1Of C,are
R7506 T8773 T8774 arg1Of used,here
R7507 T8777 T8775 arg2Of ligands,are
R7508 T8903 T8900 arg2Of step,","
R7509 T8903 T8901 arg1Of step,an
R7510 T8903 T8902 arg1Of step,essential
R7511 T8903 T8904 arg1Of step,for
R7512 T8777 T8776 arg1Of ligands,well-defined
R7513 T8777 T8778 arg1Of ligands,that
R7514 T8777 T8780 arg1Of ligands,engage
R7515 T8780 T8779 arg1Of engage,specifically
R7516 T8908 T8904 arg2Of activation,for
R7517 T8908 T8905 arg1Of activation,intact
R7518 T8908 T8906 arg1Of activation,TNFα-stimulated
R7519 T8908 T8907 arg1Of activation,NF-κB
R7520 T8912 T8909 arg1Of mutation,The
R7521 T8912 T8910 arg1Of mutation,Sharpin
R7522 T8912 T8911 arg1Of mutation,null
R7523 T8912 T8913 arg1Of mutation,disrupts
R7524 T8780 T8784 arg1Of engage,","
R7525 T8912 T8918 arg1Of mutation,abrogates
R7526 T8780 T8785 arg1Of engage,respectively
R7527 T8913 T8917 arg1Of disrupts,and
R7528 T8781 T8782 arg1Of TLR4,and
R7529 T8782 T8780 arg2Of and,engage
R7530 T8916 T8913 arg2Of process,disrupts
R7531 T8916 T8914 arg1Of process,the
R7532 T8916 T8915 arg1Of process,ubiquitylation
R7533 T8918 T8917 arg2Of abrogates,and
R7534 T8783 T8782 arg2Of TLR3,and
R7535 T8788 T8786 arg1Of profile,The
R7536 T8923 T8918 arg2Of pathway,abrogates
R7537 T8923 T8919 arg1Of pathway,the
R7538 T8923 T8920 arg1Of pathway,TNFα-induced
R7539 T8923 T8921 arg1Of pathway,NF-κB
R7540 T8923 T8922 arg1Of pathway,signaling
R7541 T8925 T8926 arg1Of TNFR,and
R7542 T8926 T8929 arg1Of and,share
R7543 T8927 T8926 arg2Of TLR,and
R7544 T8929 T8924 arg2Of share,Since
R7545 T8929 T8928 arg1Of share,partially
R7546 T8788 T8787 arg1Of profile,expression
R7547 T8788 T8789 arg1Of profile,of
R7548 T8788 T8793 arg1Of profile,is
R7549 T8933 T8929 arg2Of cascades,share
R7550 T8933 T8930 arg1Of cascades,their
R7551 T8933 T8931 arg1Of cascades,downstream
R7552 T8933 T8932 arg1Of cascades,signaling
R7553 T8788 T8794 arg1Of profile,similar
R7554 T8938 T8935 arg1Of regulation,a
R7555 T8938 T8936 arg1Of regulation,similar
R7556 T8938 T8937 arg1Of regulation,ubiquitin-mediated
R7557 T8938 T8939 arg1Of regulation,may
R7558 T8938 T8940 arg1Of regulation,hold
R7559 T8938 T8941 arg1Of regulation,true
R7560 T8940 T8924 arg1Of hold,Since
R7561 T8940 T8934 arg1Of hold,","
R7562 T8940 T8939 arg2Of hold,may
R7563 T8792 T8789 arg2Of complexes,of
R7564 T8941 T8940 arg2Of true,hold
R7565 T8941 T8942 arg1Of true,for
R7566 T8943 T8942 arg2Of SHARPIN,for
R7567 T8943 T8944 arg1Of SHARPIN,in
R7568 T8943 T8949 arg1Of SHARPIN,:
R7569 T8945 T8946 arg1Of LPS-,and
R7570 T8946 T8944 arg2Of and,in
R7571 T8947 T8946 arg2Of poly,and
R7572 T8947 T8948 arg1Of poly,I
R7573 T8792 T8790 arg1Of complexes,surface
R7574 T8792 T8791 arg1Of complexes,TLR4
R7575 T8793 T8800 modOf is,suggesting
R7576 T8952 T8949 arg2Of activation,:
R7577 T8952 T8950 arg1Of activation,C-induced
R7578 T8952 T8951 arg1Of activation,NF-κB
R7579 T8794 T8793 arg2Of similar,is
R7580 T8954 T8953 arg2Of summary,In
R7581 T8794 T8795 arg1Of similar,between
R7582 T8796 T8797 arg1Of WT,and
R7583 T8958 T8956 arg1Of study,the
R7584 T8958 T8957 arg1Of study,present
R7585 T8958 T8959 arg1Of study,identified
R7586 T8959 T8953 arg1Of identified,In
R7587 T8959 T8955 arg1Of identified,","
R7588 T8962 T8959 arg2Of role,identified
R7589 T8962 T8960 arg1Of role,an
R7590 T8962 T8961 arg1Of role,indispensible
R7591 T8962 T8963 arg1Of role,of
R7592 T8962 T8965 arg1Of role,in
R7593 T8964 T8963 arg2Of SHARPIN,of
R7594 T8797 T8795 arg2Of and,between
R7595 T8799 T8797 arg2Of BMDC,and
R7596 T8967 T8965 arg2Of production,in
R7597 T8967 T8966 arg1Of production,the
R7598 T8967 T8968 arg1Of production,of
R7599 T8970 T8969 arg1Of mediators,pro-inflammatory
R7600 T8970 T8971 arg1Of mediators,and
R7601 T8971 T8968 arg2Of and,of
R7602 T8974 T8971 arg2Of signaling,and
R7603 T8974 T8972 arg1Of signaling,TLR-induced
R7604 T8974 T8973 arg1Of signaling,NF-κB
R7605 T8799 T8798 arg1Of BMDC,cpdm
R7606 T8998 T8994 arg2Of differentiation,between
R7607 T8977 T8976 arg1Of Th1-stimulating,impaired
R7608 T8978 T8975 arg1Of ability,The
R7609 T8978 T8977 arg1Of ability,Th1-stimulating
R7610 T8978 T8979 arg1Of ability,of
R7611 T8978 T8982 arg1Of ability,may
R7612 T8978 T8983 arg1Of ability,account
R7613 T8981 T8979 arg2Of DC,of
R7614 T8981 T8980 arg1Of DC,Sharpin-deficient
R7615 T8983 T8982 arg2Of account,may
R7616 T8983 T8984 arg1Of account,for
R7617 T8998 T8995 arg1Of differentiation,Th1
R7618 T8998 T8997 arg1Of differentiation,Th2
R7619 T8988 T8984 arg2Of phenotype,for
R7620 T8988 T8985 arg1Of phenotype,the
R7621 T8988 T8986 arg1Of phenotype,Th2-dominant
R7622 T8988 T8987 arg1Of phenotype,inflammatory
R7623 T8988 T8989 arg1Of phenotype,of
R7624 T9000 T8999 arg2Of critical,is
R7625 T8991 T8989 arg2Of mice,of
R7626 T8991 T8990 arg1Of mice,cpdm
R7627 T9000 T9001 arg1Of critical,for
R7628 T9003 T9001 arg2Of homeostasis,for
R7629 T8993 T8992 arg1Of balance,The
R7630 T8993 T8994 arg1Of balance,between
R7631 T8993 T8999 arg1Of balance,is
R7632 T8993 T9000 arg1Of balance,critical
R7633 T8995 T8996 arg1Of Th1,and
R7634 T8997 T8996 arg2Of Th2,and
R7635 T9003 T9002 arg1Of homeostasis,immune
R7636 T9006 T9004 arg1Of understanding,A
R7637 T9006 T9005 arg1Of understanding,better
R7638 T9006 T9007 arg1Of understanding,of
R7639 T9006 T9013 arg1Of understanding,will
R7640 T9006 T9014 arg1Of understanding,help
R7642 T9006 T9015 arg1Of understanding,design
R7643 T9008 T9007 arg2Of how,of
R7646 T9010 T9009 arg1Of balance,such
R7647 T9010 T9011 arg1Of balance,is
R7648 T9010 T9012 arg2Of balance,maintained
R7649 T9012 T9008 arg1Of maintained,how
R7650 T9012 T9011 arg2Of maintained,is
R7651 T9015 T9013 arg2Of design,will
R7652 T9015 T9014 arg2Of design,help
R7653 T9017 T9015 arg2Of treatment,design
R7654 T9017 T9016 arg1Of treatment,cytokine
R7655 T9017 T9018 arg1Of treatment,for
R7656 T9017 T9030 arg1Of treatment,","
R7657 T9017 T9032 arg1Of treatment,as
R7658 T9020 T9018 arg2Of diseases,for
R7659 T9020 T9019 arg1Of diseases,human
R7660 T9020 T9021 arg1Of diseases,with
R7661 T9024 T9021 arg2Of secretion,with
R7662 T9024 T9022 arg1Of secretion,Th2-biased
R7663 T9024 T9023 arg1Of secretion,cytokine
R7664 T9024 T9025 arg1Of secretion,similar
R7665 T9025 T9026 arg1Of similar,to
R7666 T9029 T9026 arg2Of cpdm,to
R7667 T9029 T9027 arg1Of cpdm,the
R7668 T9029 T9028 arg1Of cpdm,mouse
R7669 T9032 T9031 arg1Of as,such
R7670 T9033 T9034 arg1Of allergies,and
R7671 T9034 T9032 arg2Of and,as
R7672 T9036 T9034 arg2Of syndromes,and
R7673 T9036 T9035 arg1Of syndromes,hypereosinophilic
R6555 T7953 T7949 arg2Of gene,of
R6556 T7953 T7950 arg1Of gene,the
R6557 T7953 T7951 arg1Of gene,mouse

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T9037 749-754 Anaphor denotes which
T9038 685-692 Antecedent denotes SHARPIN
T9039 5734-5737 Anaphor denotes its
T9040 5680-5687 Antecedent denotes SHARPIN
T9041 5921-5947 Anaphor denotes the ubiquitylation process
T9042 5738-5776 Antecedent denotes linear-ubiquitin-chain-ligase activity
R7641 T9037 T9038 boundBy which,SHARPIN
R7644 T9039 T9040 boundBy its,SHARPIN
R7645 T9041 T9042 boundBy the ubiquitylation process,linear-ubiquitin-chain-ligase activity

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T6805 11-14 DT denotes The
T6806 15-22 JJ denotes present
T6807 23-29 NN denotes report
T6808 30-36 VBD denotes showed
T6809 37-41 IN denotes that
T6810 42-46 JJ denotes null
T6811 47-56 NNS denotes mutations
T6812 57-59 IN denotes of
T6813 60-63 DT denotes the
T6814 64-69 NN denotes mouse
T6815 70-77 NNP denotes Sharpin
T6816 78-82 NN denotes gene
T6817 83-86 VBD denotes did
T6818 87-90 RB denotes not
T6819 91-97 VB denotes affect
T6820 98-101 DT denotes the
T6821 102-114 JJ denotes steady-state
T6822 115-127 NN denotes distribution
T6823 128-130 IN denotes of
T6824 131-138 JJ denotes splenic
T6825 139-141 NNP denotes DC
T6826 142-149 NNS denotes subsets
T6827 150-153 CC denotes nor
T6828 154-157 DT denotes the
T6829 158-169 NN denotes development
T6830 170-173 CC denotes and
T6831 174-183 NN denotes phenotype
T6832 184-186 IN denotes of
T6833 187-191 NNP denotes BMDC
T6834 191-192 . denotes .
T6835 193-200 RB denotes However
T6836 200-201 , denotes ,
T6837 202-206 NN denotes loss
T6838 207-209 IN denotes of
T6839 210-217 NNP denotes SHARPIN
T6840 218-231 RB denotes significantly
T6841 232-242 VBD denotes diminished
T6842 243-246 DT denotes the
T6843 247-255 NN denotes capacity
T6844 256-258 IN denotes of
T6845 259-263 NNP denotes BMDC
T6846 264-266 TO denotes to
T6847 267-274 VB denotes secrete
T6848 275-287 JJ denotes inflammatory
T6849 288-297 NNS denotes cytokines
T6850 298-301 CC denotes and
T6851 302-308 JJ denotes nitric
T6852 309-314 NN denotes oxide
T6853 314-315 . denotes .
T6854 316-319 DT denotes The
T6855 320-330 JJ denotes attenuated
T6856 331-339 NN denotes cytokine
T6857 340-350 NN denotes production
T6858 351-354 VBD denotes was
T6859 355-358 RB denotes not
T6860 359-362 JJ denotes due
T6861 363-365 TO denotes to
T6862 366-369 DT denotes the
T6863 370-378 NN denotes presence
T6864 379-381 IN denotes of
T6865 382-399 JJ denotes anti-inflammatory
T6866 400-410 NNS denotes inhibitors
T6867 410-411 , denotes ,
T6868 412-415 CC denotes and
T6869 416-419 MD denotes can
T6870 420-422 VB denotes be
T6871 423-430 RB denotes largely
T6872 431-440 VBN denotes explained
T6873 441-443 IN denotes by
T6874 444-453 JJ denotes selective
T6875 454-466 NN denotes inactivation
T6876 467-469 IN denotes of
T6877 470-475 JJ denotes NF-κB
T6878 476-485 VBG denotes signaling
T6879 485-486 . denotes .
T6880 487-497 VBN denotes Stimulated
T6881 498-502 NN denotes cpdm
T6882 503-507 NNP denotes BMDC
T6883 508-517 VBD denotes exhibited
T6884 518-528 JJ denotes Th2-biased
T6885 529-530 NNP denotes T
T6886 531-546 JJ denotes cell-polarizing
T6887 547-559 NNS denotes capabilities
T6888 559-560 , denotes ,
T6889 561-571 JJ denotes consistent
T6890 572-576 IN denotes with
T6891 577-580 DT denotes the
T6892 581-584 NNP denotes Th2
T6893 585-602 JJ denotes cytokine-dominant
T6894 603-612 NN denotes phenotype
T6895 613-615 IN denotes in
T6896 616-620 NN denotes cpdm
T6897 621-625 NNS denotes mice
T6898 625-626 . denotes .
T6899 627-635 RB denotes Together
T6900 635-636 , denotes ,
T6901 637-642 DT denotes these
T6902 643-650 NNS denotes results
T6903 651-659 VBP denotes indicate
T6904 660-662 DT denotes an
T6905 663-676 JJ denotes indispensible
T6906 677-681 NN denotes role
T6907 682-684 IN denotes of
T6908 685-692 NNP denotes SHARPIN
T6909 693-695 IN denotes in
T6910 696-706 VBG denotes regulating
T6911 707-709 NNP denotes DC
T6912 710-723 JJ denotes immunological
T6913 724-733 NNS denotes functions
T6914 733-734 , denotes ,
T6915 735-745 NN denotes disruption
T6916 746-748 IN denotes of
T6917 749-754 WDT denotes which
T6918 755-758 MD denotes may
T6919 759-769 VB denotes contribute
T6920 770-772 TO denotes to
T6921 773-776 DT denotes the
T6922 777-788 NN denotes development
T6923 789-791 IN denotes of
T6924 792-798 JJ denotes immune
T6925 799-807 NNS denotes diseases
T6926 807-808 . denotes .
T6927 809-814 IN denotes Since
T6928 815-817 NNP denotes WT
T6929 818-821 CC denotes and
T6930 822-826 NN denotes cpdm
T6931 827-831 NNS denotes mice
T6932 832-835 VBP denotes are
T6933 836-840 DT denotes both
T6934 841-849 JJ denotes specific
T6935 850-863 NN denotes pathogen-free
T6936 863-864 , denotes ,
T6937 865-868 DT denotes the
T6938 869-875 NN denotes nature
T6939 876-878 IN denotes of
T6940 879-882 DT denotes the
T6941 883-890 NN denotes trigger
T6942 891-893 IN denotes of
T6943 894-897 DT denotes the
T6944 898-904 JJ denotes severe
T6945 905-917 NN denotes inflammation
T6946 918-920 IN denotes in
T6947 921-925 NN denotes cpdm
T6948 926-930 NNS denotes mice
T6949 931-933 VBZ denotes is
T6950 934-937 RB denotes not
T6951 938-945 JJ denotes obvious
T6952 945-946 . denotes .
T6953 947-950 CD denotes One
T6954 951-955 JJ denotes such
T6955 956-966 VBG denotes initiating
T6956 967-973 NN denotes factor
T6957 974-979 MD denotes could
T6958 980-982 VB denotes be
T6959 983-993 JJ denotes endogenous
T6960 994-1003 JJ denotes apoptotic
T6961 1004-1010 CC denotes and/or
T6962 1011-1019 JJ denotes necrotic
T6963 1020-1025 NNS denotes cells
T6964 1026-1030 WDT denotes that
T6965 1031-1034 MD denotes can
T6966 1035-1042 VB denotes release
T6967 1043-1060 JJ denotes danger-associated
T6968 1061-1070 JJ denotes molecular
T6969 1071-1079 NNS denotes patterns
T6970 1080-1081 -LRB- denotes (
T6971 1081-1086 NNS denotes DAMPs
T6972 1086-1087 -RRB- denotes )
T6973 1088-1090 TO denotes to
T6974 1091-1097 VB denotes launch
T6975 1098-1101 CC denotes and
T6976 1102-1109 VB denotes amplify
T6977 1110-1112 DT denotes an
T6978 1113-1125 JJ denotes inflammatory
T6979 1126-1134 NN denotes response
T6980 1135-1136 NNP denotes [
T6981 1136-1138 CD denotes 32
T6982 1138-1139 NNP denotes ]
T6983 1139-1140 . denotes .
T6984 1141-1145 JJ denotes Such
T6985 1147-1154 JJ denotes sterile
T6986 1156-1168 NN denotes inflammation
T6987 1169-1174 MD denotes could
T6988 1175-1177 VB denotes be
T6989 1178-1187 VBN denotes initiated
T6990 1188-1191 CC denotes and
T6991 1192-1196 VB denotes take
T6992 1197-1202 NN denotes place
T6993 1203-1205 IN denotes in
T6994 1206-1209 DT denotes all
T6995 1210-1216 NNS denotes organs
T6996 1217-1220 CC denotes and
T6997 1221-1228 NNS denotes tissues
T6998 1229-1237 VBN denotes affected
T6999 1238-1240 IN denotes in
T7000 1241-1245 NN denotes cpdm
T7001 1246-1250 NNS denotes mice
T7002 1250-1251 , denotes ,
T7003 1252-1256 RB denotes thus
T7004 1257-1264 VBG denotes causing
T7005 1265-1276 JJ denotes multi-organ
T7006 1277-1289 JJ denotes inflammatory
T7007 1290-1299 NNS denotes disorders
T7008 1299-1300 . denotes .
T7009 1301-1305 DT denotes This
T7010 1306-1316 NN denotes hypothesis
T7011 1317-1319 VBZ denotes is
T7012 1320-1329 VBN denotes supported
T7013 1330-1332 IN denotes by
T7014 1333-1340 JJ denotes several
T7015 1341-1347 JJ denotes recent
T7016 1348-1355 NNS denotes studies
T7017 1355-1356 . denotes .
T7018 1357-1368 NNS denotes Fibroblasts
T7019 1369-1371 IN denotes of
T7020 1372-1376 NN denotes cpdm
T7021 1377-1381 NNS denotes mice
T7022 1382-1385 VBP denotes are
T7023 1386-1392 RB denotes highly
T7024 1393-1402 JJ denotes sensitive
T7025 1403-1405 TO denotes to
T7026 1406-1418 JJ denotes TNFα-induced
T7027 1419-1423 NN denotes cell
T7028 1424-1429 NN denotes death
T7029 1430-1433 CC denotes and
T7030 1434-1437 DT denotes the
T7031 1438-1442 NN denotes cpdm
T7032 1443-1452 NN denotes phenotype
T7033 1453-1456 MD denotes can
T7034 1457-1459 VB denotes be
T7035 1460-1469 RB denotes partially
T7036 1470-1477 VBN denotes rescued
T7037 1478-1480 IN denotes by
T7038 1481-1489 NN denotes deletion
T7039 1490-1492 IN denotes of
T7040 1493-1496 NNP denotes TNF
T7041 1497-1498 NNP denotes [
T7042 1498-1499 CD denotes 7
T7043 1499-1500 NNP denotes ]
T7044 1500-1501 , denotes ,
T7045 1502-1503 NNP denotes [
T7046 1503-1504 CD denotes 8
T7047 1504-1505 NNP denotes ]
T7048 1505-1506 , denotes ,
T7049 1507-1517 VBG denotes suggesting
T7050 1518-1522 IN denotes that
T7051 1523-1533 NN denotes deficiency
T7052 1534-1536 IN denotes of
T7053 1537-1544 NNP denotes SHARPIN
T7054 1545-1556 VBZ denotes compromises
T7055 1557-1560 DT denotes the
T7056 1561-1575 JJ denotes anti-apoptotic
T7057 1576-1586 NNS denotes mechanisms
T7058 1587-1589 IN denotes in
T7059 1590-1594 NN denotes cpdm
T7060 1595-1599 NNS denotes mice
T7061 1600-1609 VBG denotes resulting
T7062 1610-1612 IN denotes in
T7063 1613-1617 NN denotes cell
T7064 1618-1631 JJ denotes death-induced
T7065 1632-1644 JJ denotes inflammatory
T7066 1645-1652 NN denotes disease
T7067 1652-1653 . denotes .
T7068 1654-1663 NNP denotes Apoptosis
T7069 1664-1666 IN denotes of
T7070 1667-1680 NNS denotes keratinocytes
T7071 1681-1683 VBZ denotes is
T7072 1684-1685 DT denotes a
T7073 1686-1695 JJ denotes prominent
T7074 1696-1703 NN denotes feature
T7075 1704-1706 IN denotes of
T7076 1707-1710 DT denotes the
T7077 1711-1715 NN denotes skin
T7078 1716-1723 NNS denotes lesions
T7079 1724-1726 IN denotes in
T7080 1727-1731 NN denotes cpdm
T7081 1732-1736 NNS denotes mice
T7082 1737-1738 NNP denotes [
T7083 1738-1740 CD denotes 33
T7084 1740-1741 NNP denotes ]
T7085 1742-1745 CC denotes and
T7086 1746-1750 DT denotes this
T7087 1751-1753 VBZ denotes is
T7088 1754-1762 VBN denotes mediated
T7089 1763-1765 IN denotes by
T7090 1766-1783 JJ denotes caspase-dependent
T7091 1784-1797 JJ denotes mitochondrial
T7092 1798-1806 NNS denotes pathways
T7093 1807-1808 NNP denotes [
T7094 1808-1810 CD denotes 34
T7095 1810-1811 NNP denotes ]
T7096 1811-1812 . denotes .
T7097 1813-1818 DT denotes These
T7098 1819-1826 JJ denotes induced
T7099 1827-1833 CC denotes and/or
T7100 1834-1843 JJ denotes intrinsic
T7101 1844-1853 JJ denotes apoptotic
T7102 1854-1859 NNS denotes cells
T7103 1860-1863 MD denotes can
T7104 1864-1871 VB denotes release
T7105 1872-1879 JJ denotes various
T7106 1880-1885 NNS denotes types
T7107 1886-1888 IN denotes of
T7108 1889-1894 NNS denotes DAMPs
T7109 1895-1899 WDT denotes that
T7110 1900-1905 VBP denotes exert
T7111 1906-1911 PRP$ denotes their
T7112 1912-1928 JJ denotes pro-inflammatory
T7113 1929-1939 NNS denotes properties
T7114 1940-1942 IN denotes by
T7115 1943-1953 VBG denotes activating
T7116 1954-1956 NNP denotes DC
T7117 1957-1964 IN denotes through
T7118 1965-1972 NN denotes pattern
T7119 1973-1984 NN denotes recognition
T7120 1985-1994 NNS denotes receptors
T7121 1995-1996 NNP denotes [
T7122 1996-1998 CD denotes 32
T7123 1998-1999 NNP denotes ]
T7124 1999-2000 , denotes ,
T7125 2001-2002 NNP denotes [
T7126 2002-2004 CD denotes 35
T7127 2004-2005 NNP denotes ]
T7128 2005-2006 , denotes ,
T7129 2007-2011 JJ denotes such
T7130 2012-2014 IN denotes as
T7131 2015-2020 CD denotes HMGB1
T7132 2021-2031 VBN denotes recognized
T7133 2032-2034 IN denotes by
T7134 2035-2041 CD denotes TLR2/4
T7135 2042-2043 NNP denotes [
T7136 2043-2045 CD denotes 36
T7137 2045-2046 NNP denotes ]
T7138 2046-2047 , denotes ,
T7139 2048-2049 NNP denotes [
T7140 2049-2051 CD denotes 37
T7141 2051-2052 NNP denotes ]
T7142 2052-2053 . denotes .
T7143 2054-2064 JJ denotes Consistent
T7144 2065-2069 IN denotes with
T7145 2070-2073 DT denotes the
T7146 2074-2082 VBN denotes impaired
T7147 2083-2086 NNP denotes Th1
T7148 2087-2093 JJ denotes immune
T7149 2094-2102 NN denotes response
T7150 2103-2105 IN denotes in
T7151 2106-2110 NN denotes cpdm
T7152 2111-2115 NNS denotes mice
T7153 2116-2117 VBP denotes [
T7154 2117-2118 CD denotes 5
T7155 2118-2119 NNP denotes ]
T7156 2119-2120 , denotes ,
T7157 2121-2131 VBD denotes stimulated
T7158 2132-2136 NNP denotes BMDC
T7159 2137-2143 RB denotes weakly
T7160 2144-2153 VBD denotes polarized
T7161 2154-2157 CD denotes Th1
T7162 2158-2173 NN denotes differentiation
T7163 2173-2174 , denotes ,
T7164 2175-2178 CC denotes but
T7165 2179-2187 RB denotes strongly
T7166 2188-2197 VBD denotes supported
T7167 2198-2201 DT denotes the
T7168 2202-2213 NN denotes development
T7169 2214-2216 IN denotes of
T7170 2217-2220 JJ denotes Th2
T7171 2221-2229 NN denotes effector
T7172 2230-2235 NNS denotes cells
T7173 2235-2236 . denotes .
T7174 2237-2245 VBN denotes Combined
T7175 2246-2250 IN denotes with
T7176 2251-2254 DT denotes the
T7177 2255-2263 JJ denotes dramatic
T7178 2264-2270 NN denotes effect
T7179 2271-2273 IN denotes of
T7180 2274-2278 CD denotes IL12
T7181 2279-2288 NN denotes treatment
T7182 2289-2291 IN denotes on
T7183 2292-2295 DT denotes the
T7184 2296-2305 NN denotes phenotype
T7185 2306-2308 IN denotes of
T7186 2309-2314 DT denotes these
T7187 2315-2319 NNS denotes mice
T7188 2320-2321 VBP denotes [
T7189 2321-2322 CD denotes 5
T7190 2322-2323 NNP denotes ]
T7191 2323-2324 , denotes ,
T7192 2325-2329 DT denotes this
T7193 2330-2338 VBZ denotes suggests
T7194 2339-2343 IN denotes that
T7195 2344-2347 DT denotes the
T7196 2348-2358 JJ denotes Th2-biased
T7197 2359-2367 JJ denotes systemic
T7198 2368-2380 NN denotes inflammation
T7199 2381-2383 IN denotes in
T7200 2384-2388 NN denotes cpdm
T7201 2389-2393 NNS denotes mice
T7202 2394-2396 VBZ denotes is
T7203 2397-2403 VBN denotes caused
T7204 2404-2406 IN denotes by
T7205 2407-2414 JJ denotes reduced
T7206 2415-2422 JJ denotes IL12P70
T7207 2423-2433 NN denotes production
T7208 2434-2438 IN denotes from
T7209 2439-2441 NNP denotes DC
T7210 2441-2442 . denotes .
T7211 2443-2446 DT denotes The
T7212 2447-2457 NN denotes importance
T7213 2458-2460 IN denotes of
T7214 2461-2468 NNP denotes IL12P70
T7215 2469-2471 IN denotes in
T7216 2472-2482 VBG denotes regulating
T7217 2483-2486 NNP denotes Th1
T7218 2487-2490 CC denotes and
T7219 2491-2494 NNP denotes Th2
T7220 2495-2501 JJ denotes immune
T7221 2502-2511 NNS denotes responses
T7222 2512-2514 IN denotes in
T7223 2515-2519 NNS denotes mice
T7224 2520-2523 VBD denotes was
T7225 2524-2531 RB denotes clearly
T7226 2532-2544 VBN denotes demonstrated
T7227 2545-2547 IN denotes in
T7228 2548-2555 NNP denotes IL12P35
T7229 2555-2556 : denotes -
T7230 2557-2560 CC denotes and
T7231 2561-2578 JJ denotes IL12P40-deficient
T7232 2579-2583 NNS denotes mice
T7233 2584-2585 NNP denotes [
T7234 2585-2587 CD denotes 38
T7235 2587-2588 NNP denotes ]
T7236 2588-2589 , denotes ,
T7237 2590-2591 NNP denotes [
T7238 2591-2593 CD denotes 39
T7239 2593-2594 NNP denotes ]
T7240 2595-2598 CC denotes and
T7241 2599-2606 IN denotes through
T7242 2607-2615 JJ denotes clinical
T7243 2616-2623 NNS denotes studies
T7244 2624-2626 IN denotes in
T7245 2627-2632 JJ denotes human
T7246 2633-2641 NNS denotes patients
T7247 2642-2643 NNP denotes [
T7248 2643-2645 CD denotes 40
T7249 2645-2646 NNP denotes ]
T7250 2647-2648 NNP denotes [
T7251 2648-2650 CD denotes 42
T7252 2650-2651 NNP denotes ]
T7253 2651-2652 . denotes .
T7254 2653-2658 NN denotes NF-κB
T7255 2658-2659 , denotes ,
T7256 2660-2668 CD denotes TBK/IRF3
T7257 2668-2669 , denotes ,
T7258 2670-2673 CC denotes and
T7259 2674-2678 NNP denotes MAPK
T7260 2679-2688 VBG denotes signaling
T7261 2689-2692 VBP denotes are
T7262 2693-2702 JJ denotes important
T7263 2703-2711 NNS denotes pathways
T7264 2712-2721 VBN denotes activated
T7265 2722-2724 IN denotes by
T7266 2725-2728 NNP denotes LPS
T7267 2729-2731 CC denotes or
T7268 2732-2736 RB denotes poly
T7269 2737-2738 PRP denotes I
T7270 2738-2739 : denotes :
T7271 2739-2740 NNP denotes C
T7272 2741-2744 CC denotes and
T7273 2745-2755 NN denotes disruption
T7274 2756-2758 IN denotes of
T7275 2759-2765 DT denotes either
T7276 2766-2773 NN denotes pathway
T7277 2774-2777 MD denotes may
T7278 2778-2782 VB denotes lead
T7279 2783-2785 TO denotes to
T7280 2786-2795 VBN denotes decreased
T7281 2796-2804 NN denotes cytokine
T7282 2805-2815 NN denotes expression
T7283 2815-2816 . denotes .
T7284 2817-2822 JJ denotes NF-κB
T7285 2823-2833 NN denotes activation
T7286 2834-2837 VBD denotes was
T7287 2838-2849 RB denotes selectively
T7288 2850-2859 VBN denotes inhibited
T7289 2860-2862 IN denotes in
T7290 2863-2866 NNP denotes LPS
T7291 2867-2870 CC denotes and
T7292 2871-2875 RB denotes poly
T7293 2876-2877 PRP denotes I
T7294 2877-2878 : denotes :
T7295 2878-2879 NNP denotes C
T7296 2880-2890 VBD denotes stimulated
T7297 2891-2895 NN denotes cpdm
T7298 2896-2900 NNP denotes BMDC
T7299 2901-2909 VBN denotes compared
T7300 2910-2912 TO denotes to
T7301 2913-2917 JJ denotes wild
T7302 2918-2922 NN denotes type
T7303 2922-2923 , denotes ,
T7304 2924-2929 IN denotes while
T7305 2930-2940 NN denotes activation
T7306 2941-2943 IN denotes of
T7307 2944-2953 CD denotes TBK1/IRF3
T7308 2953-2954 , denotes ,
T7309 2955-2961 NNP denotes ERK1/2
T7310 2961-2962 , denotes ,
T7311 2963-2965 CC denotes or
T7312 2966-2969 CD denotes p38
T7313 2970-2973 VBD denotes was
T7314 2974-2977 RB denotes not
T7315 2977-2978 , denotes ,
T7316 2979-2989 VBG denotes indicating
T7317 2990-2994 IN denotes that
T7318 2995-3004 VBN denotes disrupted
T7319 3005-3010 NNP denotes NF-κB
T7320 3011-3020 VBG denotes signaling
T7321 3021-3023 IN denotes in
T7322 3024-3028 NN denotes cpdm
T7323 3029-3031 NNP denotes DC
T7324 3032-3034 VBZ denotes is
T7325 3035-3046 JJ denotes responsible
T7326 3047-3050 IN denotes for
T7327 3051-3054 DT denotes the
T7328 3055-3064 JJ denotes defective
T7329 3065-3073 NN denotes cytokine
T7330 3074-3084 NN denotes expression
T7331 3084-3085 . denotes .
T7332 3086-3091 DT denotes These
T7333 3092-3099 NNS denotes results
T7334 3100-3104 VBP denotes seem
T7335 3105-3107 TO denotes to
T7336 3108-3118 VB denotes contradict
T7337 3119-3120 DT denotes a
T7338 3121-3127 JJ denotes recent
T7339 3128-3133 NN denotes study
T7340 3134-3138 WDT denotes that
T7341 3139-3144 VBD denotes found
T7342 3145-3154 VBN denotes increased
T7343 3155-3161 NNS denotes levels
T7344 3162-3164 IN denotes of
T7345 3165-3170 JJ denotes NF-κB
T7346 3171-3181 NN denotes activation
T7347 3182-3185 CC denotes and
T7348 3186-3189 CD denotes IL1
T7349 3190-3203 NN denotes transcription
T7350 3204-3206 IN denotes in
T7351 3207-3211 NN denotes cpdm
T7352 3212-3216 NNS denotes mice
T7353 3217-3218 NNP denotes [
T7354 3218-3220 CD denotes 43
T7355 3220-3221 NNP denotes ]
T7356 3221-3222 . denotes .
T7357 3223-3227 DT denotes This
T7358 3228-3238 NN denotes difference
T7359 3239-3242 MD denotes can
T7360 3243-3251 RB denotes probably
T7361 3252-3254 VB denotes be
T7362 3255-3265 VBN denotes attributed
T7363 3266-3268 TO denotes to
T7364 3269-3272 DT denotes the
T7365 3273-3282 JJ denotes different
T7366 3283-3288 NNS denotes cells
T7367 3289-3292 CC denotes and
T7368 3293-3300 NNS denotes tissues
T7369 3301-3305 VBN denotes used
T7370 3306-3308 IN denotes in
T7371 3309-3314 DT denotes these
T7372 3315-3322 NNS denotes studies
T7373 3322-3323 , denotes ,
T7374 3324-3327 CC denotes and
T7375 3328-3331 MD denotes may
T7376 3332-3337 VB denotes point
T7377 3338-3340 TO denotes to
T7378 3341-3345 NN denotes cell
T7379 3345-3346 : denotes -
T7380 3347-3350 CC denotes and
T7381 3351-3357 NN denotes tissue
T7382 3357-3358 : denotes -
T7383 3359-3363 NN denotes type
T7384 3364-3372 JJ denotes specific
T7385 3373-3382 NNS denotes functions
T7386 3383-3385 IN denotes of
T7387 3386-3393 NNP denotes SHARPIN
T7388 3393-3394 . denotes .
T7389 3395-3399 DT denotes This
T7390 3400-3402 VBZ denotes is
T7391 3403-3413 JJ denotes consistent
T7392 3414-3418 IN denotes with
T7393 3419-3425 JJ denotes recent
T7394 3426-3433 NNS denotes reports
T7395 3434-3436 IN denotes of
T7396 3437-3452 JJ denotes tissue-specific
T7397 3453-3460 NNS denotes effects
T7398 3461-3463 IN denotes of
T7399 3464-3469 JJ denotes NF-κB
T7400 3470-3479 VBG denotes signaling
T7401 3480-3481 NNP denotes [
T7402 3481-3483 CD denotes 44
T7403 3483-3484 NNP denotes ]
T7404 3484-3485 . denotes .
T7405 3486-3496 JJ denotes Ubiquitous
T7406 3497-3507 NN denotes activation
T7407 3508-3510 IN denotes of
T7408 3511-3516 NN denotes NF-κB
T7409 3517-3519 IN denotes by
T7410 3520-3528 VBG denotes removing
T7411 3529-3539 NNS denotes inhibitors
T7412 3540-3544 JJ denotes such
T7413 3545-3547 IN denotes as
T7414 3548-3551 NNP denotes A20
T7415 3552-3555 CC denotes and
T7416 3556-3560 NNP denotes ITCH
T7417 3561-3568 IN denotes through
T7418 3569-3576 JJ denotes genetic
T7419 3577-3589 NN denotes manipulation
T7420 3590-3597 NNS denotes results
T7421 3598-3600 IN denotes in
T7422 3601-3611 JJ denotes widespread
T7423 3612-3624 NN denotes inflammation
T7424 3624-3625 , denotes ,
T7425 3626-3636 JJ denotes consistent
T7426 3637-3641 IN denotes with
T7427 3642-3645 DT denotes the
T7428 3646-3650 NN denotes role
T7429 3651-3653 IN denotes of
T7430 3654-3659 NN denotes NF-κB
T7431 3660-3662 IN denotes in
T7432 3663-3666 DT denotes the
T7433 3667-3677 NN denotes production
T7434 3678-3680 IN denotes of
T7435 3681-3697 JJ denotes pro-inflammatory
T7436 3698-3707 NNS denotes mediators
T7437 3708-3709 NNP denotes [
T7438 3709-3711 CD denotes 45
T7439 3711-3712 NNP denotes ]
T7440 3712-3713 , denotes ,
T7441 3714-3715 NNP denotes [
T7442 3715-3717 CD denotes 46
T7443 3717-3718 NNP denotes ]
T7444 3718-3719 . denotes .
T7445 3720-3727 RB denotes However
T7446 3727-3728 , denotes ,
T7447 3729-3738 JJ denotes selective
T7448 3739-3749 NN denotes inhibition
T7449 3750-3752 IN denotes of
T7450 3753-3758 JJ denotes NF-κB
T7451 3759-3769 NN denotes activation
T7452 3770-3772 IN denotes in
T7453 3773-3784 JJ denotes parenchymal
T7454 3785-3790 NNS denotes cells
T7455 3791-3793 IN denotes of
T7456 3794-3797 DT denotes the
T7457 3798-3802 NN denotes skin
T7458 3802-3803 , denotes ,
T7459 3804-3809 NN denotes liver
T7460 3809-3810 , denotes ,
T7461 3811-3814 CC denotes and
T7462 3815-3824 JJ denotes intestine
T7463 3825-3832 NNS denotes results
T7464 3833-3835 IN denotes in
T7465 3836-3843 JJ denotes chronic
T7466 3844-3856 NN denotes inflammation
T7467 3857-3863 VBN denotes driven
T7468 3864-3866 IN denotes by
T7469 3867-3872 JJ denotes NF-κB
T7470 3873-3882 JJ denotes competent
T7471 3883-3893 NNS denotes leukocytes
T7472 3894-3895 NNP denotes [
T7473 3895-3897 CD denotes 47
T7474 3897-3898 NNP denotes ]
T7475 3899-3900 NNP denotes [
T7476 3900-3902 CD denotes 50
T7477 3902-3903 NNP denotes ]
T7478 3903-3904 . denotes .
T7479 3905-3909 DT denotes This
T7480 3910-3919 VBZ denotes indicates
T7481 3920-3924 IN denotes that
T7482 3925-3926 DT denotes a
T7483 3927-3934 NN denotes balance
T7484 3935-3942 IN denotes between
T7485 3943-3946 DT denotes the
T7486 3947-3963 JJ denotes pro-inflammatory
T7487 3964-3968 NN denotes role
T7488 3969-3971 IN denotes of
T7489 3972-3977 NN denotes NF-κB
T7490 3978-3980 IN denotes in
T7491 3981-3991 NNS denotes leukocytes
T7492 3992-3995 CC denotes and
T7493 3996-3999 DT denotes the
T7494 4000-4017 JJ denotes anti-inflammatory
T7495 4018-4022 NN denotes role
T7496 4023-4025 IN denotes in
T7497 4026-4037 JJ denotes parenchymal
T7498 4038-4043 NNS denotes cells
T7499 4044-4046 VBZ denotes is
T7500 4047-4055 JJ denotes critical
T7501 4056-4058 IN denotes in
T7502 4059-4062 DT denotes the
T7503 4063-4074 NN denotes maintenance
T7504 4075-4077 IN denotes of
T7505 4078-4084 NN denotes tissue
T7506 4085-4096 NN denotes homeostasis
T7507 4096-4097 . denotes .
T7508 4098-4109 NNS denotes Experiments
T7509 4110-4114 IN denotes with
T7510 4115-4119 NNS denotes mice
T7511 4120-4124 IN denotes with
T7512 4125-4129 NN denotes cell
T7513 4129-4130 : denotes -
T7514 4131-4134 CC denotes and
T7515 4135-4150 JJ denotes tissue-specific
T7516 4151-4159 NN denotes deletion
T7517 4160-4162 IN denotes of
T7518 4163-4170 NNP denotes Sharpin
T7519 4170-4171 , denotes ,
T7520 4172-4181 RB denotes currently
T7521 4182-4187 IN denotes under
T7522 4188-4191 NN denotes way
T7523 4191-4192 , denotes ,
T7524 4193-4197 MD denotes will
T7525 4198-4202 VB denotes help
T7526 4203-4205 TO denotes to
T7527 4206-4215 VB denotes elucidate
T7528 4216-4219 DT denotes the
T7529 4220-4224 NN denotes role
T7530 4225-4227 IN denotes of
T7531 4228-4235 NNP denotes SHARPIN
T7532 4236-4238 IN denotes in
T7533 4239-4251 NN denotes inflammation
T7534 4251-4252 . denotes .
T7535 4253-4260 IN denotes Despite
T7536 4261-4270 JJ denotes defective
T7537 4271-4276 NN denotes NF-κB
T7538 4277-4287 NN denotes activation
T7539 4288-4290 IN denotes in
T7540 4291-4294 DT denotes the
T7541 4295-4302 NN denotes absence
T7542 4303-4305 IN denotes of
T7543 4306-4313 NNP denotes Sharpin
T7544 4314-4324 NN denotes expression
T7545 4324-4325 , denotes ,
T7546 4326-4331 EX denotes there
T7547 4332-4335 VBD denotes was
T7548 4336-4338 DT denotes no
T7549 4339-4350 JJ denotes significant
T7550 4351-4357 NN denotes change
T7551 4358-4360 IN denotes in
T7552 4361-4368 JJ denotes splenic
T7553 4369-4371 NNP denotes DC
T7554 4372-4383 NNS denotes populations
T7555 4384-4386 CC denotes or
T7556 4387-4397 NN denotes expression
T7557 4398-4400 IN denotes of
T7558 4401-4415 JJ denotes co-stimulatory
T7559 4416-4425 NNS denotes molecules
T7560 4426-4428 IN denotes on
T7561 4429-4433 NNP denotes BMDC
T7562 4433-4434 . denotes .
T7563 4435-4444 JJ denotes Different
T7564 4445-4450 NN denotes NF-κB
T7565 4451-4459 NNS denotes subunits
T7566 4460-4468 VBN denotes involved
T7567 4469-4471 IN denotes in
T7568 4472-4475 DT denotes the
T7569 4476-4485 JJ denotes canonical
T7570 4486-4489 CC denotes and
T7571 4490-4503 JJ denotes non-canonical
T7572 4504-4512 NNS denotes branches
T7573 4513-4515 IN denotes of
T7574 4516-4519 DT denotes the
T7575 4520-4525 NNP denotes NF-κB
T7576 4526-4535 VBG denotes signaling
T7577 4536-4543 NN denotes pathway
T7578 4544-4548 VBP denotes have
T7579 4549-4557 JJ denotes distinct
T7580 4558-4567 NNS denotes functions
T7581 4568-4570 TO denotes to
T7582 4571-4578 VB denotes control
T7583 4579-4587 JJ denotes specific
T7584 4588-4595 NNS denotes aspects
T7585 4596-4598 IN denotes of
T7586 4599-4601 NNP denotes DC
T7587 4602-4613 NN denotes development
T7588 4614-4617 CC denotes and
T7589 4618-4626 NN denotes function
T7590 4627-4628 NNP denotes [
T7591 4628-4630 CD denotes 51
T7592 4630-4631 NNP denotes ]
T7593 4631-4632 , denotes ,
T7594 4633-4634 NNP denotes [
T7595 4634-4636 CD denotes 52
T7596 4636-4637 NNP denotes ]
T7597 4637-4638 . denotes .
T7598 4639-4642 DT denotes The
T7599 4643-4656 JJ denotes non-canonical
T7600 4657-4664 NN denotes pathway
T7601 4665-4666 -LRB- denotes (
T7602 4666-4670 JJ denotes p100
T7603 4671-4681 NN denotes processing
T7604 4682-4684 TO denotes to
T7605 4685-4692 VB denotes produce
T7606 4693-4696 CD denotes p52
T7607 4696-4697 -RRB- denotes )
T7608 4698-4705 VBZ denotes appears
T7609 4706-4708 TO denotes to
T7610 4709-4711 VB denotes be
T7611 4712-4718 JJ denotes intact
T7612 4719-4721 IN denotes in
T7613 4722-4739 JJ denotes SHARPIN-deficient
T7614 4740-4745 NNS denotes cells
T7615 4746-4747 VBP denotes [
T7616 4747-4748 CD denotes 7
T7617 4748-4749 NNP denotes ]
T7618 4749-4750 , denotes ,
T7619 4751-4752 NNP denotes [
T7620 4752-4753 CD denotes 9
T7621 4753-4754 NNP denotes ]
T7622 4755-4765 VBG denotes suggesting
T7623 4766-4770 IN denotes that
T7624 4771-4774 DT denotes the
T7625 4775-4780 JJ denotes NF-κB
T7626 4781-4792 NN denotes heterodimer
T7627 4793-4801 NN denotes p52/RELB
T7628 4802-4804 VBZ denotes is
T7629 4805-4815 JJ denotes sufficient
T7630 4816-4818 TO denotes to
T7631 4819-4827 VB denotes maintain
T7632 4828-4831 DT denotes the
T7633 4832-4838 JJ denotes normal
T7634 4839-4849 NN denotes regulation
T7635 4850-4852 IN denotes of
T7636 4853-4855 NNP denotes DC
T7637 4856-4867 NN denotes homeostasis
T7638 4868-4871 CC denotes and
T7639 4872-4882 NN denotes maturation
T7640 4882-4883 . denotes .
T7641 4884-4887 DT denotes The
T7642 4888-4897 JJ denotes molecular
T7643 4898-4903 NN denotes basis
T7644 4904-4906 IN denotes by
T7645 4907-4912 WDT denotes which
T7646 4913-4916 DT denotes the
T7647 4917-4924 NNP denotes Sharpin
T7648 4925-4933 NN denotes mutation
T7649 4934-4940 VBZ denotes causes
T7650 4941-4948 VBN denotes reduced
T7651 4949-4954 JJ denotes NF-κB
T7652 4955-4965 NN denotes activation
T7653 4966-4968 IN denotes in
T7654 4969-4973 NNP denotes BMDC
T7655 4974-4981 VBZ denotes remains
T7656 4982-4984 TO denotes to
T7657 4985-4987 VB denotes be
T7658 4988-4998 VBN denotes determined
T7659 4998-4999 . denotes .
T7660 5000-5003 NNP denotes LPS
T7661 5004-5007 CC denotes and
T7662 5008-5012 RB denotes poly
T7663 5013-5014 PRP denotes I
T7664 5014-5015 : denotes :
T7665 5015-5016 NNP denotes C
T7666 5017-5021 VBD denotes used
T7667 5022-5026 RB denotes here
T7668 5027-5030 VBP denotes are
T7669 5031-5043 JJ denotes well-defined
T7670 5044-5051 NNS denotes ligands
T7671 5052-5056 WDT denotes that
T7672 5057-5069 RB denotes specifically
T7673 5070-5076 VBP denotes engage
T7674 5077-5081 CD denotes TLR4
T7675 5082-5085 CC denotes and
T7676 5086-5090 CD denotes TLR3
T7677 5090-5091 , denotes ,
T7678 5092-5104 RB denotes respectively
T7679 5104-5105 . denotes .
T7680 5106-5109 DT denotes The
T7681 5110-5120 NN denotes expression
T7682 5121-5128 NN denotes profile
T7683 5129-5131 IN denotes of
T7684 5132-5139 NN denotes surface
T7685 5140-5144 CD denotes TLR4
T7686 5145-5154 NNS denotes complexes
T7687 5155-5157 VBZ denotes is
T7688 5158-5165 JJ denotes similar
T7689 5166-5173 IN denotes between
T7690 5174-5176 NNP denotes WT
T7691 5177-5180 CC denotes and
T7692 5181-5185 VB denotes cpdm
T7693 5186-5190 NNP denotes BMDC
T7694 5191-5201 VBG denotes suggesting
T7695 5202-5206 IN denotes that
T7696 5207-5216 JJ denotes defective
T7697 5217-5222 NN denotes NF-κB
T7698 5223-5233 NN denotes activation
T7699 5234-5236 VBZ denotes is
T7700 5237-5240 RB denotes not
T7701 5241-5242 DT denotes a
T7702 5243-5249 NN denotes result
T7703 5250-5252 IN denotes of
T7704 5253-5265 JJ denotes differential
T7705 5266-5269 NNP denotes TLR
T7706 5270-5280 NN denotes expression
T7707 5281-5283 IN denotes on
T7708 5284-5290 NN denotes target
T7709 5291-5296 NNS denotes cells
T7710 5296-5297 . denotes .
T7711 5298-5301 NNP denotes LPS
T7712 5302-5309 VBZ denotes engages
T7713 5310-5314 CD denotes TLR4
T7714 5315-5317 TO denotes to
T7715 5318-5326 VB denotes activate
T7716 5327-5342 JJ denotes MYD88-dependent
T7717 5343-5346 CC denotes and
T7718 5347-5361 JJ denotes TRIF-dependent
T7719 5362-5370 NNS denotes pathways
T7720 5370-5371 , denotes ,
T7721 5372-5379 IN denotes whereas
T7722 5380-5384 CD denotes TLR3
T7723 5385-5395 VBN denotes stimulated
T7724 5396-5398 IN denotes by
T7725 5399-5403 NN denotes poly
T7726 5404-5405 PRP denotes I
T7727 5405-5406 : denotes :
T7728 5406-5407 NNP denotes C
T7729 5408-5412 RB denotes only
T7730 5413-5421 VBZ denotes triggers
T7731 5422-5436 JJ denotes TRIF-dependent
T7732 5437-5446 VBG denotes signaling
T7733 5447-5448 NNP denotes [
T7734 5448-5450 CD denotes 53
T7735 5450-5451 NNP denotes ]
T7736 5451-5452 . denotes .
T7737 5453-5456 DT denotes The
T7738 5457-5466 JJ denotes defective
T7739 5467-5472 NN denotes NF-κB
T7740 5473-5483 NN denotes activation
T7741 5484-5486 IN denotes by
T7742 5487-5491 DT denotes both
T7743 5492-5499 NNS denotes stimuli
T7744 5500-5508 VBZ denotes suggests
T7745 5509-5513 IN denotes that
T7746 5514-5517 DT denotes the
T7747 5518-5525 NNP denotes Sharpin
T7748 5526-5534 NN denotes mutation
T7749 5535-5545 VBZ denotes interferes
T7750 5546-5550 IN denotes with
T7751 5551-5554 DT denotes the
T7752 5555-5562 NN denotes protein
T7753 5563-5571 NNS denotes adaptors
T7754 5572-5574 CC denotes or
T7755 5575-5582 NNS denotes kinases
T7756 5583-5589 VBN denotes shared
T7757 5590-5592 IN denotes by
T7758 5593-5597 DT denotes both
T7759 5598-5607 VBG denotes signaling
T7760 5608-5616 NNS denotes pathways
T7761 5616-5617 , denotes ,
T7762 5618-5622 JJ denotes such
T7763 5623-5625 IN denotes as
T7764 5626-5630 CD denotes RIP1
T7765 5631-5634 CC denotes and
T7766 5635-5640 CD denotes TRAF6
T7767 5641-5642 NNP denotes [
T7768 5642-5644 CD denotes 18
T7769 5644-5645 NNP denotes ]
T7770 5645-5646 . denotes .
T7771 5647-5653 JJ denotes Recent
T7772 5654-5661 NNS denotes studies
T7773 5662-5674 VBD denotes demonstrated
T7774 5675-5679 IN denotes that
T7775 5680-5687 NNP denotes SHARPIN
T7776 5688-5697 NNS denotes interacts
T7777 5698-5702 IN denotes with
T7778 5703-5707 NNP denotes HOIP
T7779 5708-5710 TO denotes to
T7780 5711-5715 VB denotes form
T7781 5716-5721 NNP denotes LUBAC
T7782 5722-5726 IN denotes that
T7783 5727-5733 VBZ denotes exerts
T7784 5734-5737 PRP$ denotes its
T7785 5738-5767 JJ denotes linear-ubiquitin-chain-ligase
T7786 5768-5776 NN denotes activity
T7787 5777-5779 IN denotes on
T7788 5780-5785 JJ denotes NF-κB
T7789 5786-5795 VBG denotes signaling
T7790 5796-5803 NNS denotes players
T7791 5804-5808 NNP denotes RIP1
T7792 5809-5812 CC denotes and
T7793 5813-5817 NNP denotes NEMO
T7794 5818-5819 NNP denotes [
T7795 5819-5820 CD denotes 7
T7796 5820-5821 NNP denotes ]
T7797 5821-5822 , denotes ,
T7798 5823-5825 DT denotes an
T7799 5826-5835 JJ denotes essential
T7800 5836-5840 NN denotes step
T7801 5841-5844 IN denotes for
T7802 5845-5851 JJ denotes intact
T7803 5852-5867 JJ denotes TNFα-stimulated
T7804 5868-5873 NN denotes NF-κB
T7805 5874-5884 NN denotes activation
T7806 5884-5885 . denotes .
T7807 5886-5889 DT denotes The
T7808 5890-5897 NNP denotes Sharpin
T7809 5898-5902 NN denotes null
T7810 5903-5911 NN denotes mutation
T7811 5912-5920 VBZ denotes disrupts
T7812 5921-5924 DT denotes the
T7813 5925-5939 NN denotes ubiquitylation
T7814 5940-5947 NN denotes process
T7815 5948-5951 CC denotes and
T7816 5952-5961 VBZ denotes abrogates
T7817 5962-5965 DT denotes the
T7818 5966-5978 JJ denotes TNFα-induced
T7819 5979-5984 NN denotes NF-κB
T7820 5985-5994 VBG denotes signaling
T7821 5995-6002 NN denotes pathway
T7822 6002-6003 . denotes .
T7823 6004-6009 IN denotes Since
T7824 6010-6014 NNP denotes TNFR
T7825 6015-6018 CC denotes and
T7826 6019-6022 NNP denotes TLR
T7827 6023-6032 RB denotes partially
T7828 6033-6038 VBP denotes share
T7829 6039-6044 PRP$ denotes their
T7830 6045-6055 JJ denotes downstream
T7831 6056-6065 VBG denotes signaling
T7832 6066-6074 NNS denotes cascades
T7833 6074-6075 , denotes ,
T7834 6076-6077 DT denotes a
T7835 6078-6085 JJ denotes similar
T7836 6086-6104 JJ denotes ubiquitin-mediated
T7837 6105-6115 NN denotes regulation
T7838 6116-6119 MD denotes may
T7839 6120-6124 VB denotes hold
T7840 6125-6129 JJ denotes true
T7841 6130-6133 IN denotes for
T7842 6134-6141 NNP denotes SHARPIN
T7843 6142-6144 IN denotes in
T7844 6145-6148 NNP denotes LPS
T7845 6148-6149 : denotes -
T7846 6150-6153 CC denotes and
T7847 6154-6158 RB denotes poly
T7848 6159-6160 PRP denotes I
T7849 6160-6161 : denotes :
T7850 6161-6170 JJ denotes C-induced
T7851 6171-6176 JJ denotes NF-κB
T7852 6177-6187 NN denotes activation
T7853 6187-6188 . denotes .
T7854 6189-6191 IN denotes In
T7855 6192-6199 NN denotes summary
T7856 6199-6200 , denotes ,
T7857 6201-6204 DT denotes the
T7858 6205-6212 JJ denotes present
T7859 6213-6218 NN denotes study
T7860 6219-6229 VBD denotes identified
T7861 6230-6232 DT denotes an
T7862 6233-6246 JJ denotes indispensible
T7863 6247-6251 NN denotes role
T7864 6252-6254 IN denotes of
T7865 6255-6262 NNP denotes SHARPIN
T7866 6263-6265 IN denotes in
T7867 6266-6269 DT denotes the
T7868 6270-6280 NN denotes production
T7869 6281-6283 IN denotes of
T7870 6284-6300 JJ denotes pro-inflammatory
T7871 6301-6310 NNS denotes mediators
T7872 6311-6314 CC denotes and
T7873 6315-6326 JJ denotes TLR-induced
T7874 6327-6332 NN denotes NF-κB
T7875 6333-6342 VBG denotes signaling
T7876 6342-6343 . denotes .
T7877 6344-6347 DT denotes The
T7878 6348-6356 VBN denotes impaired
T7879 6357-6372 NN denotes Th1-stimulating
T7880 6373-6380 NN denotes ability
T7881 6381-6383 IN denotes of
T7882 6384-6401 JJ denotes Sharpin-deficient
T7883 6402-6404 NNP denotes DC
T7884 6405-6408 MD denotes may
T7885 6409-6416 VB denotes account
T7886 6417-6420 IN denotes for
T7887 6421-6424 DT denotes the
T7888 6425-6437 JJ denotes Th2-dominant
T7889 6438-6450 JJ denotes inflammatory
T7890 6451-6460 NN denotes phenotype
T7891 6461-6463 IN denotes of
T7892 6464-6468 NN denotes cpdm
T7893 6469-6473 NNS denotes mice
T7894 6473-6474 . denotes .
T7895 6475-6478 DT denotes The
T7896 6479-6486 NN denotes balance
T7897 6487-6494 IN denotes between
T7898 6495-6498 CD denotes Th1
T7899 6499-6502 CC denotes and
T7900 6503-6506 CD denotes Th2
T7901 6507-6522 NN denotes differentiation
T7902 6523-6525 VBZ denotes is
T7903 6526-6534 JJ denotes critical
T7904 6535-6538 IN denotes for
T7905 6539-6545 JJ denotes immune
T7906 6546-6557 NN denotes homeostasis
T7907 6557-6558 . denotes .
T7908 6559-6560 DT denotes A
T7909 6561-6567 JJR denotes better
T7910 6568-6581 NN denotes understanding
T7911 6582-6584 IN denotes of
T7912 6585-6588 WRB denotes how
T7913 6589-6593 JJ denotes such
T7914 6594-6601 NN denotes balance
T7915 6602-6604 VBZ denotes is
T7916 6605-6615 VBN denotes maintained
T7917 6616-6620 MD denotes will
T7918 6621-6625 VB denotes help
T7919 6626-6632 NN denotes design
T7920 6633-6641 NN denotes cytokine
T7921 6642-6651 NN denotes treatment
T7922 6652-6655 IN denotes for
T7923 6656-6661 JJ denotes human
T7924 6662-6670 NNS denotes diseases
T7925 6671-6675 IN denotes with
T7926 6676-6686 JJ denotes Th2-biased
T7927 6687-6695 NN denotes cytokine
T7928 6696-6705 NN denotes secretion
T7929 6706-6713 JJ denotes similar
T7930 6714-6716 TO denotes to
T7931 6717-6720 DT denotes the
T7932 6721-6726 NN denotes mouse
T7933 6727-6731 NN denotes cpdm
T7934 6731-6732 , denotes ,
T7935 6733-6737 JJ denotes such
T7936 6738-6740 IN denotes as
T7937 6741-6750 NNS denotes allergies
T7938 6751-6754 CC denotes and
T7939 6755-6772 JJ denotes hypereosinophilic
T7940 6773-6782 NNS denotes syndromes
T7941 6782-6783 . denotes .
R5411 T6805 T6807 det The,report
R5412 T6806 T6807 amod present,report
R5413 T6807 T6808 nsubj report,showed
R5414 T6808 T6808 ROOT showed,showed
R5415 T6809 T6819 mark that,affect
R5416 T6810 T6811 amod null,mutations
R5417 T6811 T6819 nsubj mutations,affect
R5418 T6812 T6811 prep of,mutations
R5419 T6813 T6816 det the,gene
R5420 T6814 T6816 compound mouse,gene
R5421 T6815 T6816 compound Sharpin,gene
R5422 T6816 T6812 pobj gene,of
R5423 T6817 T6819 aux did,affect
R5424 T6818 T6819 neg not,affect
R5425 T6819 T6808 ccomp affect,showed
R5426 T6820 T6822 det the,distribution
R5427 T6821 T6822 amod steady-state,distribution
R5428 T6822 T6819 dobj distribution,affect
R5429 T6823 T6822 prep of,distribution
R5430 T6824 T6826 amod splenic,subsets
R5431 T6825 T6826 compound DC,subsets
R5432 T6826 T6823 pobj subsets,of
R5433 T6827 T6822 cc nor,distribution
R5434 T6828 T6829 det the,development
R5435 T6829 T6822 conj development,distribution
R5436 T6830 T6829 cc and,development
R5437 T6831 T6829 conj phenotype,development
R5438 T6832 T6829 prep of,development
R5439 T6833 T6832 pobj BMDC,of
R5440 T6834 T6808 punct .,showed
R5441 T6835 T6841 advmod However,diminished
R5442 T6836 T6841 punct ",",diminished
R5443 T6837 T6841 nsubj loss,diminished
R5444 T6838 T6837 prep of,loss
R5445 T6839 T6838 pobj SHARPIN,of
R5446 T6840 T6841 advmod significantly,diminished
R5459 T6853 T6841 punct .,diminished
R5460 T6854 T6857 det The,production
R5461 T6855 T6857 amod attenuated,production
R5462 T6856 T6857 compound cytokine,production
R5463 T6857 T6858 nsubj production,was
R5464 T6858 T6858 ROOT was,was
R5465 T6859 T6858 neg not,was
R5466 T6860 T6858 acomp due,was
R5467 T6861 T6860 prep to,due
R5468 T6862 T6863 det the,presence
R5469 T6863 T6861 pobj presence,to
R5470 T6864 T6863 prep of,presence
R5471 T6865 T6866 amod anti-inflammatory,inhibitors
R5472 T6866 T6864 pobj inhibitors,of
R5473 T6867 T6858 punct ",",was
R5474 T6868 T6858 cc and,was
R5475 T6869 T6872 aux can,explained
R5476 T6870 T6872 auxpass be,explained
R5477 T6871 T6872 advmod largely,explained
R5478 T6872 T6858 conj explained,was
R5479 T6873 T6872 agent by,explained
R5480 T6874 T6875 amod selective,inactivation
R5481 T6875 T6873 pobj inactivation,by
R5482 T6876 T6875 prep of,inactivation
R5483 T6877 T6878 amod NF-κB,signaling
R5484 T6878 T6876 pobj signaling,of
R5485 T6879 T6872 punct .,explained
R5486 T6880 T6883 advcl Stimulated,exhibited
R5487 T6881 T6882 compound cpdm,BMDC
R5488 T6882 T6883 nsubj BMDC,exhibited
R5489 T6883 T6883 ROOT exhibited,exhibited
R5490 T6884 T6887 amod Th2-biased,capabilities
R5491 T6885 T6887 compound T,capabilities
R5492 T6886 T6887 compound cell-polarizing,capabilities
R5493 T6887 T6883 dobj capabilities,exhibited
R5494 T6888 T6887 punct ",",capabilities
R5495 T6889 T6887 amod consistent,capabilities
R5496 T6890 T6889 prep with,consistent
R5497 T6891 T6894 det the,phenotype
R5498 T6892 T6894 nmod Th2,phenotype
R5499 T6893 T6894 amod cytokine-dominant,phenotype
R5500 T6894 T6890 pobj phenotype,with
R5501 T6895 T6894 prep in,phenotype
R5502 T6896 T6897 compound cpdm,mice
R5503 T6897 T6895 pobj mice,in
R5504 T6898 T6883 punct .,exhibited
R5505 T6899 T6903 advmod Together,indicate
R5506 T6900 T6903 punct ",",indicate
R5507 T6901 T6902 det these,results
R5508 T6902 T6903 nsubj results,indicate
R5509 T6903 T6903 ROOT indicate,indicate
R5510 T6904 T6906 det an,role
R5511 T6905 T6906 amod indispensible,role
R5512 T6906 T6903 dobj role,indicate
R5513 T6907 T6906 prep of,role
R5514 T6908 T6907 pobj SHARPIN,of
R5515 T6909 T6906 prep in,role
R5516 T6910 T6909 pcomp regulating,in
R5517 T6911 T6913 nmod DC,functions
R5518 T6912 T6913 amod immunological,functions
R5519 T6913 T6910 dobj functions,regulating
R5520 T6914 T6915 punct ",",disruption
R5521 T6915 T6919 nsubj disruption,contribute
R5522 T6916 T6915 prep of,disruption
R5523 T6917 T6916 pobj which,of
R5524 T6918 T6919 aux may,contribute
R5525 T6919 T6903 ccomp contribute,indicate
R5526 T6920 T6919 prep to,contribute
R5527 T6921 T6922 det the,development
R5528 T6922 T6920 pobj development,to
R5529 T6923 T6922 prep of,development
R5530 T6924 T6925 amod immune,diseases
R5531 T6925 T6923 pobj diseases,of
R5532 T6926 T6903 punct .,indicate
R5533 T6927 T6932 mark Since,are
R5534 T6928 T6931 nmod WT,mice
R5535 T6929 T6928 cc and,WT
R5536 T6930 T6931 compound cpdm,mice
R5537 T6931 T6932 nsubj mice,are
R5538 T6932 T6949 csubj are,is
R5539 T6933 T6932 dep both,are
R5540 T6934 T6935 amod specific,pathogen-free
R5541 T6935 T6932 attr pathogen-free,are
R5542 T6936 T6935 punct ",",pathogen-free
R5543 T6937 T6938 det the,nature
R5544 T6938 T6935 appos nature,pathogen-free
R5545 T6939 T6938 prep of,nature
R5546 T6940 T6941 det the,trigger
R5547 T6941 T6939 pobj trigger,of
R5548 T6942 T6941 prep of,trigger
R5549 T6943 T6945 det the,inflammation
R5550 T6944 T6945 amod severe,inflammation
R5551 T6945 T6942 pobj inflammation,of
R5552 T6946 T6945 prep in,inflammation
R5553 T6947 T6948 compound cpdm,mice
R5554 T6948 T6946 pobj mice,in
R5555 T6949 T6949 ROOT is,is
R5556 T6950 T6949 neg not,is
R5557 T6951 T6949 acomp obvious,is
R5558 T6952 T6949 punct .,is
R5559 T6953 T6956 nummod One,factor
R5560 T6954 T6956 amod such,factor
R5561 T6955 T6956 amod initiating,factor
R5562 T6956 T6958 nsubj factor,be
R5563 T6957 T6958 aux could,be
R5564 T6958 T6958 ROOT be,be
R5565 T6959 T6960 advmod endogenous,apoptotic
R5566 T6960 T6963 amod apoptotic,cells
R5567 T6961 T6960 cc and/or,apoptotic
R5568 T6962 T6960 conj necrotic,apoptotic
R5569 T6963 T6958 attr cells,be
R5570 T6964 T6966 nsubj that,release
R5571 T6965 T6966 aux can,release
R5572 T6966 T6963 relcl release,cells
R5573 T6967 T6969 amod danger-associated,patterns
R5574 T6968 T6969 amod molecular,patterns
R5575 T6969 T6966 dobj patterns,release
R5576 T6970 T6969 punct (,patterns
R5577 T6971 T6969 appos DAMPs,patterns
R5578 T6972 T6969 punct ),patterns
R5579 T6973 T6974 aux to,launch
R5580 T6974 T6966 advcl launch,release
R5581 T6975 T6974 cc and,launch
R5582 T6976 T6974 conj amplify,launch
R5583 T6977 T6979 det an,response
R5584 T6978 T6979 amod inflammatory,response
R5585 T6979 T6976 dobj response,amplify
R5586 T6980 T6982 nmod [,]
R5587 T6981 T6982 nummod 32,]
R5588 T6982 T6979 appos ],response
R5589 T6983 T6958 punct .,be
R5590 T6984 T6986 amod Such,inflammation
R5591 T6985 T6986 amod sterile,inflammation
R5592 T6986 T6989 nsubjpass inflammation,initiated
R5593 T6987 T6989 aux could,initiated
R5594 T6988 T6989 auxpass be,initiated
R5595 T6989 T6989 ROOT initiated,initiated
R5596 T6990 T6989 cc and,initiated
R5597 T6991 T6989 conj take,initiated
R5598 T6992 T6991 dobj place,take
R5599 T6993 T6991 prep in,take
R5600 T6994 T6995 det all,organs
R5601 T6995 T6993 pobj organs,in
R5602 T6996 T6995 cc and,organs
R5603 T6997 T6995 conj tissues,organs
R5604 T6998 T6997 acl affected,tissues
R5605 T6999 T6998 prep in,affected
R5606 T7000 T7001 compound cpdm,mice
R5607 T7001 T6999 pobj mice,in
R5608 T7002 T6991 punct ",",take
R5609 T7003 T7004 advmod thus,causing
R5610 T7004 T6991 advcl causing,take
R5611 T7005 T7007 amod multi-organ,disorders
R5612 T7006 T7007 amod inflammatory,disorders
R5613 T7007 T7004 dobj disorders,causing
R5614 T7008 T6989 punct .,initiated
R5615 T7009 T7010 det This,hypothesis
R5616 T7010 T7012 nsubjpass hypothesis,supported
R5617 T7011 T7012 auxpass is,supported
R5618 T7012 T7012 ROOT supported,supported
R5619 T7013 T7012 agent by,supported
R5620 T7014 T7016 amod several,studies
R5621 T7015 T7016 amod recent,studies
R5622 T7016 T7013 pobj studies,by
R5623 T7017 T7012 punct .,supported
R5624 T7018 T7022 nsubj Fibroblasts,are
R5625 T7019 T7018 prep of,Fibroblasts
R5626 T7020 T7021 amod cpdm,mice
R5627 T7021 T7019 pobj mice,of
R5628 T7022 T7022 ROOT are,are
R5629 T7023 T7024 advmod highly,sensitive
R5630 T7024 T7022 acomp sensitive,are
R5631 T7025 T7024 prep to,sensitive
R5632 T7026 T7028 amod TNFα-induced,death
R5633 T7027 T7028 compound cell,death
R5634 T7028 T7025 pobj death,to
R5635 T7029 T7028 cc and,death
R5636 T7030 T7032 det the,phenotype
R5637 T7031 T7032 compound cpdm,phenotype
R5638 T7032 T7028 conj phenotype,death
R5639 T7033 T7036 aux can,rescued
R5640 T7034 T7036 auxpass be,rescued
R5641 T7035 T7036 advmod partially,rescued
R5642 T7036 T7022 conj rescued,are
R5643 T7037 T7036 agent by,rescued
R5644 T7038 T7037 pobj deletion,by
R5645 T7039 T7038 prep of,deletion
R5646 T7040 T7041 compound TNF,[
R5647 T7041 T7043 nmod [,]
R5648 T7042 T7043 nummod 7,]
R5649 T7043 T7039 pobj ],of
R5650 T7044 T7043 punct ",",]
R5651 T7045 T7047 nmod [,]
R5652 T7046 T7047 nummod 8,]
R5653 T7047 T7043 conj ],]
R5654 T7048 T7036 punct ",",rescued
R5655 T7049 T7036 advcl suggesting,rescued
R5656 T7050 T7054 mark that,compromises
R5657 T7051 T7054 nsubj deficiency,compromises
R5658 T7052 T7051 prep of,deficiency
R5659 T7053 T7052 pobj SHARPIN,of
R5660 T7054 T7049 ccomp compromises,suggesting
R5661 T7055 T7057 det the,mechanisms
R5662 T7056 T7057 amod anti-apoptotic,mechanisms
R5663 T7057 T7054 dobj mechanisms,compromises
R5664 T7058 T7054 prep in,compromises
R5665 T7059 T7060 compound cpdm,mice
R5666 T7060 T7058 pobj mice,in
R5667 T7061 T7060 acl resulting,mice
R5668 T7062 T7061 prep in,resulting
R5669 T7063 T7066 nmod cell,disease
R5670 T7064 T7066 amod death-induced,disease
R5671 T7065 T7066 amod inflammatory,disease
R5672 T7066 T7062 pobj disease,in
R5673 T7067 T7036 punct .,rescued
R5674 T7068 T7071 nsubj Apoptosis,is
R5675 T7069 T7068 prep of,Apoptosis
R5676 T7070 T7069 pobj keratinocytes,of
R5695 T7089 T7088 agent by,mediated
R5696 T7090 T7092 amod caspase-dependent,pathways
R5697 T7091 T7092 amod mitochondrial,pathways
R5698 T7092 T7089 pobj pathways,by
R5699 T7093 T7095 nmod [,]
R5700 T7094 T7095 nummod 34,]
R5701 T7095 T7092 appos ],pathways
R5702 T7096 T7071 punct .,is
R5703 T7097 T7098 nsubj These,induced
R5704 T7098 T7104 advmod induced,release
R5705 T7099 T7098 cc and/or,induced
R5706 T7100 T7098 conj intrinsic,induced
R5707 T7101 T7102 amod apoptotic,cells
R5708 T7102 T7104 nsubj cells,release
R5709 T7103 T7104 aux can,release
R5710 T7104 T7104 ROOT release,release
R5711 T7105 T7106 amod various,types
R5712 T7106 T7104 dobj types,release
R5713 T7107 T7106 prep of,types
R5714 T7108 T7107 pobj DAMPs,of
R5715 T7109 T7110 nsubj that,exert
R5716 T7110 T7108 relcl exert,DAMPs
R5717 T7111 T7113 poss their,properties
R5718 T7112 T7113 compound pro-inflammatory,properties
R5719 T7113 T7110 dobj properties,exert
R5727 T7121 T7123 nmod [,]
R5807 T7201 T7199 pobj mice,in
R5835 T7229 T7226 punct -,demonstrated
R5836 T7230 T7226 cc and,demonstrated
R5837 T7231 T7232 amod IL12P40-deficient,mice
R5838 T7232 T7226 conj mice,demonstrated
R5839 T7233 T7235 nmod [,]
R5840 T7234 T7235 nummod 38,]
R5841 T7235 T7232 appos ],mice
R5842 T7236 T7235 punct ",",]
R5843 T7237 T7239 nmod [,]
R5844 T7238 T7239 nummod 39,]
R5845 T7239 T7235 conj ],]
R5846 T7240 T7232 cc and,mice
R5847 T7241 T7232 conj through,mice
R5848 T7242 T7243 amod clinical,studies
R5849 T7243 T7241 pobj studies,through
R5850 T7244 T7243 prep in,studies
R5851 T7245 T7246 amod human,patients
R5852 T7246 T7244 pobj patients,in
R5853 T7247 T7249 nmod [,]
R5854 T7248 T7249 nummod 40,]
R5855 T7249 T7243 appos ],studies
R5856 T7250 T7252 nmod [,]
R5857 T7251 T7252 nummod 42,]
R5858 T7252 T7249 appos ],]
R5859 T7253 T7226 punct .,demonstrated
R5860 T7254 T7261 nsubj NF-κB,are
R5861 T7255 T7254 punct ",",NF-κB
R5862 T7256 T7254 appos TBK/IRF3,NF-κB
R5863 T7257 T7254 punct ",",NF-κB
R5864 T7258 T7254 cc and,NF-κB
R5865 T7259 T7254 conj MAPK,NF-κB
R5866 T7260 T7254 conj signaling,NF-κB
R5867 T7261 T7261 ROOT are,are
R5868 T7262 T7263 amod important,pathways
R5869 T7263 T7261 attr pathways,are
R5870 T7264 T7263 acl activated,pathways
R5871 T7265 T7264 agent by,activated
R5872 T7266 T7265 pobj LPS,by
R5873 T7267 T7264 cc or,activated
R5874 T7268 T7271 advmod poly,C
R5875 T7269 T7271 nsubj I,C
R5876 T7270 T7271 punct :,C
R5877 T7271 T7261 dep C,are
R5878 T7272 T7271 cc and,C
R5879 T7273 T7271 conj disruption,C
R5880 T7274 T7273 prep of,disruption
R5881 T7275 T7276 det either,pathway
R5882 T7276 T7274 pobj pathway,of
R5883 T7277 T7278 aux may,lead
R5884 T7278 T7261 advcl lead,are
R5885 T7279 T7278 prep to,lead
R5886 T7280 T7282 amod decreased,expression
R5887 T7281 T7282 compound cytokine,expression
R5888 T7282 T7279 pobj expression,to
R5889 T7283 T7261 punct .,are
R5890 T7284 T7285 amod NF-κB,activation
R5891 T7285 T7288 nsubjpass activation,inhibited
R5892 T7286 T7288 auxpass was,inhibited
R5893 T7287 T7288 advmod selectively,inhibited
R5894 T7288 T7288 ROOT inhibited,inhibited
R5895 T7289 T7288 prep in,inhibited
R5896 T7290 T7289 pobj LPS,in
R5897 T7291 T7288 cc and,inhibited
R5898 T7292 T7296 advmod poly,stimulated
R5899 T7293 T7296 dep I,stimulated
R5900 T7294 T7296 punct :,stimulated
R5901 T7295 T7296 npadvmod C,stimulated
R5902 T7296 T7288 conj stimulated,inhibited
R5903 T7297 T7298 compound cpdm,BMDC
R5904 T7298 T7296 dobj BMDC,stimulated
R5905 T7299 T7296 prep compared,stimulated
R5906 T7300 T7299 prep to,compared
R5907 T7301 T7302 amod wild,type
R5908 T7302 T7300 pobj type,to
R5909 T7303 T7296 punct ",",stimulated
R5910 T7304 T7313 mark while,was
R5911 T7305 T7313 nsubj activation,was
R5912 T7306 T7305 prep of,activation
R5913 T7307 T7306 pobj TBK1/IRF3,of
R5914 T7308 T7305 punct ",",activation
R5915 T7309 T7305 conj ERK1/2,activation
R5916 T7310 T7309 punct ",",ERK1/2
R5917 T7311 T7309 cc or,ERK1/2
R5918 T7312 T7309 conj p38,ERK1/2
R5919 T7313 T7296 advcl was,stimulated
R5920 T7314 T7313 neg not,was
R5921 T7315 T7296 punct ",",stimulated
R5922 T7316 T7296 advcl indicating,stimulated
R5923 T7317 T7318 mark that,disrupted
R5924 T7318 T7316 ccomp disrupted,indicating
R5925 T7319 T7320 nsubj NF-κB,signaling
R5926 T7320 T7318 ccomp signaling,disrupted
R5927 T7321 T7320 prep in,signaling
R5928 T7322 T7323 compound cpdm,DC
R5929 T7323 T7321 pobj DC,in
R5930 T7324 T7320 ccomp is,signaling
R5931 T7325 T7324 acomp responsible,is
R5932 T7326 T7325 prep for,responsible
R5933 T7327 T7330 det the,expression
R5934 T7328 T7330 amod defective,expression
R5935 T7329 T7330 compound cytokine,expression
R5936 T7330 T7326 pobj expression,for
R5937 T7331 T7296 punct .,stimulated
R5938 T7332 T7333 det These,results
R5939 T7333 T7334 nsubj results,seem
R5940 T7334 T7334 ROOT seem,seem
R5941 T7335 T7336 aux to,contradict
R5942 T7336 T7334 xcomp contradict,seem
R5943 T7337 T7339 det a,study
R5944 T7338 T7339 amod recent,study
R5945 T7339 T7336 dobj study,contradict
R5946 T7340 T7341 nsubj that,found
R5947 T7341 T7339 relcl found,study
R5948 T7342 T7343 amod increased,levels
R5949 T7343 T7341 dobj levels,found
R5950 T7344 T7343 prep of,levels
R5951 T7345 T7346 amod NF-κB,activation
R5952 T7346 T7344 pobj activation,of
R5953 T7347 T7346 cc and,activation
R5954 T7348 T7349 nummod IL1,transcription
R5955 T7349 T7346 conj transcription,activation
R5956 T7350 T7349 prep in,transcription
R5957 T7351 T7352 compound cpdm,mice
R5958 T7352 T7350 pobj mice,in
R5959 T7353 T7355 nmod [,]
R5960 T7354 T7355 nummod 43,]
R5961 T7355 T7352 appos ],mice
R5962 T7356 T7334 punct .,seem
R5963 T7357 T7358 det This,difference
R5964 T7358 T7362 nsubjpass difference,attributed
R5965 T7359 T7362 aux can,attributed
R5966 T7360 T7362 advmod probably,attributed
R5967 T7361 T7362 auxpass be,attributed
R5968 T7362 T7362 ROOT attributed,attributed
R5969 T7363 T7362 prep to,attributed
R5970 T7364 T7366 det the,cells
R5971 T7365 T7366 amod different,cells
R5972 T7366 T7363 pobj cells,to
R5973 T7367 T7366 cc and,cells
R5974 T7368 T7366 conj tissues,cells
R5975 T7369 T7368 acl used,tissues
R5976 T7370 T7369 prep in,used
R5977 T7371 T7372 det these,studies
R5978 T7372 T7370 pobj studies,in
R5979 T7373 T7362 punct ",",attributed
R5980 T7374 T7362 cc and,attributed
R5981 T7375 T7376 aux may,point
R5982 T7376 T7362 conj point,attributed
R5983 T7377 T7376 prep to,point
R5984 T7378 T7377 pobj cell,to
R5985 T7379 T7377 punct -,to
R5986 T7380 T7377 cc and,to
R5987 T7381 T7383 compound tissue,type
R5988 T7382 T7383 punct -,type
R5989 T7383 T7377 pobj type,to
R5990 T7384 T7385 amod specific,functions
R5991 T7385 T7383 dobj functions,type
R5992 T7386 T7385 prep of,functions
R5993 T7387 T7386 pobj SHARPIN,of
R5994 T7388 T7362 punct .,attributed
R5995 T7389 T7390 nsubj This,is
R5996 T7390 T7390 ROOT is,is
R5997 T7391 T7390 acomp consistent,is
R5998 T7392 T7391 prep with,consistent
R5999 T7393 T7394 amod recent,reports
R6000 T7394 T7392 pobj reports,with
R6001 T7395 T7394 prep of,reports
R6002 T7396 T7397 amod tissue-specific,effects
R6003 T7397 T7395 pobj effects,of
R6004 T7398 T7397 prep of,effects
R6005 T7399 T7400 nsubj NF-κB,signaling
R6006 T7400 T7398 pcomp signaling,of
R6007 T7401 T7403 nmod [,]
R6008 T7402 T7403 nummod 44,]
R6009 T7403 T7400 dobj ],signaling
R6010 T7404 T7390 punct .,is
R6011 T7405 T7406 amod Ubiquitous,activation
R6012 T7406 T7406 ROOT activation,activation
R6013 T7407 T7406 prep of,activation
R6014 T7408 T7407 pobj NF-κB,of
R6015 T7409 T7406 prep by,activation
R6016 T7410 T7409 pcomp removing,by
R6017 T7411 T7410 dobj inhibitors,removing
R6018 T7412 T7413 amod such,as
R6019 T7413 T7411 prep as,inhibitors
R6020 T7414 T7413 pobj A20,as
R6021 T7415 T7414 cc and,A20
R6022 T7416 T7414 conj ITCH,A20
R6023 T7417 T7410 prep through,removing
R6024 T7418 T7419 amod genetic,manipulation
R6025 T7419 T7420 compound manipulation,results
R6026 T7420 T7417 pobj results,through
R6027 T7421 T7420 prep in,results
R6028 T7422 T7423 amod widespread,inflammation
R6029 T7423 T7421 pobj inflammation,in
R6030 T7424 T7423 punct ",",inflammation
R6031 T7425 T7420 amod consistent,results
R6032 T7426 T7425 prep with,consistent
R6033 T7427 T7428 det the,role
R6034 T7428 T7426 pobj role,with
R6035 T7429 T7428 prep of,role
R6036 T7430 T7429 pobj NF-κB,of
R6037 T7431 T7428 prep in,role
R6038 T7432 T7433 det the,production
R6039 T7433 T7431 pobj production,in
R6040 T7434 T7433 prep of,production
R6041 T7435 T7436 amod pro-inflammatory,mediators
R6042 T7436 T7434 pobj mediators,of
R6043 T7437 T7433 appos [,production
R6044 T7438 T7439 nummod 45,]
R6045 T7439 T7428 appos ],role
R6046 T7440 T7439 punct ",",]
R6047 T7441 T7443 nmod [,]
R6048 T7442 T7443 nummod 46,]
R6049 T7443 T7439 appos ],]
R6050 T7444 T7406 punct .,activation
R6051 T7445 T7445 ROOT However,However
R6052 T7446 T7445 pobj ",",However
R6053 T7447 T7448 amod selective,inhibition
R6054 T7448 T7477 nmod inhibition,]
R6055 T7449 T7448 prep of,inhibition
R6056 T7450 T7451 amod NF-κB,activation
R6057 T7451 T7449 pobj activation,of
R6058 T7452 T7451 prep in,activation
R6059 T7453 T7454 amod parenchymal,cells
R6060 T7454 T7452 pobj cells,in
R6061 T7455 T7454 prep of,cells
R6062 T7456 T7457 det the,skin
R6063 T7457 T7455 pobj skin,of
R6064 T7458 T7457 punct ",",skin
R6065 T7459 T7457 conj liver,skin
R6066 T7460 T7459 punct ",",liver
R6067 T7461 T7459 cc and,liver
R6068 T7462 T7463 compound intestine,results
R6069 T7463 T7448 conj results,inhibition
R6070 T7464 T7448 prep in,inhibition
R6071 T7465 T7466 amod chronic,inflammation
R6072 T7466 T7464 pobj inflammation,in
R6073 T7467 T7466 acl driven,inflammation
R6074 T7468 T7467 agent by,driven
R6075 T7469 T7471 amod NF-κB,leukocytes
R6076 T7470 T7471 amod competent,leukocytes
R6077 T7471 T7468 pobj leukocytes,by
R6078 T7472 T7474 nmod [,]
R6079 T7473 T7474 nummod 47,]
R6080 T7474 T7475 meta ],[
R6081 T7475 T7477 nmod [,]
R6082 T7476 T7477 nummod 50,]
R6083 T7477 T7446 dative ],","
R6084 T7478 T7477 punct .,]
R6085 T7479 T7480 nsubj This,indicates
R6086 T7480 T7480 ROOT indicates,indicates
R6087 T7481 T7499 mark that,is
R6088 T7482 T7483 det a,balance
R6089 T7483 T7499 nsubj balance,is
R6090 T7484 T7483 prep between,balance
R6091 T7485 T7487 det the,role
R6092 T7486 T7487 amod pro-inflammatory,role
R6093 T7487 T7484 pobj role,between
R6094 T7488 T7487 prep of,role
R6095 T7489 T7488 pobj NF-κB,of
R6096 T7490 T7487 prep in,role
R6097 T7491 T7490 pobj leukocytes,in
R6098 T7492 T7491 cc and,leukocytes
R6099 T7493 T7495 det the,role
R6100 T7494 T7495 amod anti-inflammatory,role
R6101 T7495 T7499 nsubj role,is
R6102 T7496 T7495 prep in,role
R6103 T7497 T7498 amod parenchymal,cells
R6104 T7498 T7496 pobj cells,in
R6105 T7499 T7480 ccomp is,indicates
R6106 T7500 T7499 acomp critical,is
R6107 T7501 T7500 prep in,critical
R6108 T7502 T7503 det the,maintenance
R6109 T7503 T7501 pobj maintenance,in
R6110 T7504 T7503 prep of,maintenance
R6111 T7505 T7506 compound tissue,homeostasis
R6112 T7506 T7504 pobj homeostasis,of
R6113 T7507 T7480 punct .,indicates
R6114 T7508 T7525 nsubj Experiments,help
R6115 T7509 T7508 prep with,Experiments
R6116 T7510 T7509 pobj mice,with
R6117 T7511 T7508 prep with,Experiments
R6118 T7512 T7511 pobj cell,with
R6119 T7513 T7508 punct -,Experiments
R6120 T7514 T7508 cc and,Experiments
R6121 T7515 T7516 amod tissue-specific,deletion
R6122 T7516 T7508 conj deletion,Experiments
R6123 T7517 T7516 prep of,deletion
R6124 T7518 T7517 pobj Sharpin,of
R6125 T7519 T7518 punct ",",Sharpin
R6126 T7520 T7521 advmod currently,under
R6127 T7521 T7516 prep under,deletion
R6128 T7522 T7521 pobj way,under
R6129 T7523 T7525 punct ",",help
R6130 T7524 T7525 aux will,help
R6131 T7525 T7525 ROOT help,help
R6132 T7526 T7527 aux to,elucidate
R6133 T7527 T7525 xcomp elucidate,help
R6134 T7528 T7529 det the,role
R6135 T7529 T7527 dobj role,elucidate
R6136 T7530 T7529 prep of,role
R6137 T7531 T7530 pobj SHARPIN,of
R6138 T7532 T7529 prep in,role
R6139 T7533 T7532 pobj inflammation,in
R6140 T7534 T7525 punct .,help
R6141 T7535 T7547 prep Despite,was
R6142 T7536 T7538 amod defective,activation
R6143 T7537 T7538 compound NF-κB,activation
R6144 T7538 T7535 pobj activation,Despite
R6145 T7539 T7538 prep in,activation
R6146 T7540 T7541 det the,absence
R6147 T7541 T7539 pobj absence,in
R6148 T7542 T7541 prep of,absence
R6149 T7543 T7544 compound Sharpin,expression
R6150 T7544 T7542 pobj expression,of
R6151 T7545 T7547 punct ",",was
R6152 T7546 T7547 expl there,was
R6153 T7547 T7547 ROOT was,was
R6154 T7548 T7550 det no,change
R6155 T7549 T7550 amod significant,change
R6156 T7550 T7547 attr change,was
R6157 T7551 T7550 prep in,change
R6158 T7552 T7554 amod splenic,populations
R6159 T7553 T7554 compound DC,populations
R6160 T7554 T7551 pobj populations,in
R6161 T7555 T7554 cc or,populations
R6162 T7556 T7550 conj expression,change
R6163 T7557 T7556 prep of,expression
R6164 T7558 T7559 amod co-stimulatory,molecules
R6165 T7559 T7557 pobj molecules,of
R6166 T7560 T7547 prep on,was
R6167 T7561 T7560 pobj BMDC,on
R6168 T7562 T7547 punct .,was
R6169 T7563 T7565 amod Different,subunits
R6170 T7564 T7565 compound NF-κB,subunits
R6171 T7565 T7578 nsubj subunits,have
R6172 T7566 T7565 acl involved,subunits
R6173 T7567 T7566 prep in,involved
R6174 T7568 T7572 det the,branches
R6175 T7569 T7572 amod canonical,branches
R6176 T7570 T7569 cc and,canonical
R6177 T7571 T7569 conj non-canonical,canonical
R6178 T7572 T7567 pobj branches,in
R6179 T7573 T7572 prep of,branches
R6180 T7574 T7577 det the,pathway
R6181 T7575 T7577 nmod NF-κB,pathway
R6182 T7576 T7577 amod signaling,pathway
R6183 T7577 T7573 pobj pathway,of
R6184 T7578 T7578 ROOT have,have
R6185 T7579 T7580 amod distinct,functions
R6186 T7580 T7578 dobj functions,have
R6187 T7581 T7582 aux to,control
R6188 T7582 T7580 acl control,functions
R6189 T7583 T7584 amod specific,aspects
R6190 T7584 T7582 dobj aspects,control
R6191 T7585 T7584 prep of,aspects
R6192 T7586 T7587 compound DC,development
R6193 T7587 T7585 pobj development,of
R6194 T7588 T7587 cc and,development
R6195 T7589 T7582 conj function,control
R6196 T7590 T7592 nmod [,]
R6197 T7591 T7592 nummod 51,]
R6198 T7592 T7589 dobj ],function
R6199 T7593 T7592 punct ",",]
R6200 T7594 T7592 conj [,]
R6201 T7595 T7596 nummod 52,]
R6202 T7596 T7592 conj ],]
R6203 T7597 T7578 punct .,have
R6204 T7598 T7600 det The,pathway
R6205 T7599 T7600 amod non-canonical,pathway
R6206 T7600 T7608 nsubj pathway,appears
R6207 T7601 T7600 punct (,pathway
R6208 T7602 T7603 amod p100,processing
R6209 T7603 T7600 appos processing,pathway
R6210 T7604 T7605 aux to,produce
R6211 T7605 T7603 relcl produce,processing
R6212 T7606 T7605 dobj p52,produce
R6213 T7607 T7600 punct ),pathway
R6214 T7608 T7608 ROOT appears,appears
R6215 T7609 T7610 aux to,be
R6216 T7610 T7608 xcomp be,appears
R6217 T7611 T7610 acomp intact,be
R6218 T7612 T7611 prep in,intact
R6219 T7613 T7614 amod SHARPIN-deficient,cells
R6220 T7614 T7612 pobj cells,in
R6221 T7615 T7617 nmod [,]
R6222 T7616 T7617 nummod 7,]
R6223 T7617 T7622 nsubj ],suggesting
R6224 T7618 T7617 punct ",",]
R6225 T7619 T7621 nmod [,]
R6226 T7620 T7621 nummod 9,]
R6227 T7621 T7617 conj ],]
R6228 T7622 T7608 advcl suggesting,appears
R6229 T7623 T7628 mark that,is
R6230 T7624 T7627 det the,p52/RELB
R6231 T7625 T7627 amod NF-κB,p52/RELB
R6232 T7626 T7627 compound heterodimer,p52/RELB
R6233 T7627 T7628 nsubj p52/RELB,is
R6234 T7628 T7622 ccomp is,suggesting
R6235 T7629 T7628 acomp sufficient,is
R6236 T7630 T7631 aux to,maintain
R6237 T7631 T7629 xcomp maintain,sufficient
R6238 T7632 T7634 det the,regulation
R6239 T7633 T7634 amod normal,regulation
R6240 T7634 T7631 dobj regulation,maintain
R6241 T7635 T7634 prep of,regulation
R6242 T7636 T7637 compound DC,homeostasis
R6243 T7637 T7635 pobj homeostasis,of
R6244 T7638 T7637 cc and,homeostasis
R6245 T7639 T7637 conj maturation,homeostasis
R6246 T7640 T7608 punct .,appears
R6247 T7641 T7643 det The,basis
R6248 T7642 T7643 amod molecular,basis
R6249 T7643 T7649 nsubj basis,causes
R6250 T7644 T7649 prep by,causes
R6251 T7645 T7644 pobj which,by
R6252 T7646 T7648 det the,mutation
R6253 T7647 T7648 compound Sharpin,mutation
R6254 T7648 T7649 nsubj mutation,causes
R6255 T7649 T7649 ROOT causes,causes
R6256 T7650 T7652 amod reduced,activation
R6257 T7651 T7652 amod NF-κB,activation
R6258 T7652 T7655 nsubj activation,remains
R6259 T7653 T7652 prep in,activation
R6260 T7654 T7653 pobj BMDC,in
R6261 T7655 T7649 ccomp remains,causes
R6262 T7656 T7658 aux to,determined
R6263 T7657 T7658 auxpass be,determined
R6264 T7658 T7655 xcomp determined,remains
R6265 T7659 T7655 punct .,remains
R6266 T7660 T7660 ROOT LPS,LPS
R6267 T7661 T7660 cc and,LPS
R6268 T7662 T7660 conj poly,LPS
R6269 T7663 T7668 nsubj I,are
R6270 T7664 T7668 punct :,are
R6271 T7665 T7666 npadvmod C,used
R6272 T7666 T7668 csubj used,are
R6273 T7667 T7666 advmod here,used
R6274 T7668 T7668 ROOT are,are
R6275 T7669 T7670 amod well-defined,ligands
R6276 T7670 T7668 attr ligands,are
R6277 T7671 T7673 nsubj that,engage
R6278 T7672 T7673 advmod specifically,engage
R6279 T7673 T7670 relcl engage,ligands
R6280 T7674 T7673 dobj TLR4,engage
R6281 T7675 T7674 cc and,TLR4
R6282 T7676 T7674 conj TLR3,TLR4
R6283 T7677 T7673 punct ",",engage
R6284 T7678 T7673 advmod respectively,engage
R6285 T7679 T7668 punct .,are
R6286 T7680 T7682 det The,profile
R6287 T7681 T7682 compound expression,profile
R6288 T7682 T7687 nsubj profile,is
R6289 T7683 T7682 prep of,profile
R6290 T7684 T7683 pobj surface,of
R6291 T7685 T7684 nummod TLR4,surface
R6292 T7686 T7682 appos complexes,profile
R6293 T7687 T7687 ROOT is,is
R6294 T7688 T7687 acomp similar,is
R6295 T7689 T7688 prep between,similar
R6296 T7690 T7689 pobj WT,between
R6297 T7691 T7690 cc and,WT
R6298 T7692 T7693 compound cpdm,BMDC
R6299 T7693 T7690 conj BMDC,WT
R6300 T7694 T7687 advcl suggesting,is
R6301 T7695 T7699 mark that,is
R6302 T7696 T7698 amod defective,activation
R6303 T7697 T7698 compound NF-κB,activation
R6304 T7698 T7699 nsubj activation,is
R6305 T7699 T7694 ccomp is,suggesting
R6306 T7700 T7699 neg not,is
R6307 T7701 T7702 det a,result
R6308 T7702 T7699 attr result,is
R6309 T7703 T7702 prep of,result
R6310 T7704 T7706 compound differential,expression
R6311 T7705 T7706 compound TLR,expression
R6312 T7706 T7703 pobj expression,of
R6313 T7707 T7706 prep on,expression
R6314 T7708 T7709 compound target,cells
R6315 T7709 T7707 pobj cells,on
R6316 T7710 T7687 punct .,is
R6317 T7711 T7712 nsubj LPS,engages
R6318 T7712 T7730 ccomp engages,triggers
R6319 T7713 T7712 dobj TLR4,engages
R6320 T7714 T7715 aux to,activate
R6321 T7715 T7712 advcl activate,engages
R6322 T7716 T7719 amod MYD88-dependent,pathways
R6323 T7717 T7716 cc and,MYD88-dependent
R6324 T7718 T7716 conj TRIF-dependent,MYD88-dependent
R6325 T7719 T7715 dobj pathways,activate
R6326 T7720 T7712 punct ",",engages
R6327 T7721 T7723 mark whereas,stimulated
R6328 T7722 T7723 nummod TLR3,stimulated
R6329 T7723 T7712 advcl stimulated,engages
R6330 T7724 T7723 agent by,stimulated
R6331 T7725 T7724 pobj poly,by
R6332 T7726 T7725 nummod I,poly
R6333 T7727 T7730 punct :,triggers
R6334 T7728 T7730 nsubj C,triggers
R6335 T7729 T7730 advmod only,triggers
R6336 T7730 T7730 ROOT triggers,triggers
R6337 T7731 T7732 nsubj TRIF-dependent,signaling
R6338 T7732 T7730 ccomp signaling,triggers
R6339 T7733 T7735 nmod [,]
R6340 T7734 T7735 nummod 53,]
R6341 T7735 T7732 dobj ],signaling
R6342 T7736 T7730 punct .,triggers
R6343 T7737 T7740 det The,activation
R6344 T7738 T7740 amod defective,activation
R6345 T7739 T7740 compound NF-κB,activation
R6346 T7740 T7744 nsubj activation,suggests
R6347 T7741 T7740 prep by,activation
R6348 T7742 T7743 det both,stimuli
R6349 T7743 T7741 pobj stimuli,by
R6350 T7744 T7744 ROOT suggests,suggests
R6351 T7745 T7749 mark that,interferes
R6352 T7746 T7748 det the,mutation
R6353 T7747 T7748 compound Sharpin,mutation
R6354 T7748 T7749 nsubj mutation,interferes
R6355 T7749 T7744 ccomp interferes,suggests
R6356 T7750 T7749 prep with,interferes
R6357 T7751 T7753 det the,adaptors
R6358 T7752 T7753 compound protein,adaptors
R6359 T7753 T7750 pobj adaptors,with
R6360 T7754 T7753 cc or,adaptors
R6361 T7755 T7753 conj kinases,adaptors
R6362 T7756 T7753 acl shared,adaptors
R6363 T7757 T7756 agent by,shared
R6364 T7758 T7760 det both,pathways
R6365 T7759 T7760 amod signaling,pathways
R6366 T7760 T7757 pobj pathways,by
R6367 T7761 T7760 punct ",",pathways
R6368 T7762 T7763 amod such,as
R6369 T7763 T7760 prep as,pathways
R6370 T7764 T7763 pobj RIP1,as
R6371 T7765 T7764 cc and,RIP1
R6372 T7766 T7764 conj TRAF6,RIP1
R6373 T7767 T7769 nmod [,]
R6374 T7768 T7769 nummod 18,]
R6375 T7769 T7760 appos ],pathways
R6376 T7770 T7744 punct .,suggests
R6377 T7771 T7772 amod Recent,studies
R6378 T7772 T7773 nsubj studies,demonstrated
R6379 T7773 T7773 ROOT demonstrated,demonstrated
R6380 T7774 T7776 mark that,interacts
R6381 T7775 T7776 nsubj SHARPIN,interacts
R6382 T7776 T7773 ccomp interacts,demonstrated
R6383 T7777 T7776 prep with,interacts
R6393 T7787 T7786 prep on,activity
R6394 T7788 T7789 amod NF-κB,signaling
R6395 T7789 T7787 pobj signaling,on
R6396 T7790 T7791 compound players,RIP1
R6397 T7791 T7796 nmod RIP1,]
R6398 T7792 T7791 cc and,RIP1
R6399 T7793 T7794 compound NEMO,[
R6400 T7794 T7791 conj [,RIP1
R6401 T7795 T7796 nummod 7,]
R6402 T7796 T7789 dobj ],signaling
R6403 T7797 T7796 punct ",",]
R6404 T7798 T7800 det an,step
R6405 T7799 T7800 amod essential,step
R6406 T7800 T7796 appos step,]
R6407 T7801 T7800 prep for,step
R6408 T7802 T7805 amod intact,activation
R6409 T7803 T7805 amod TNFα-stimulated,activation
R6410 T7804 T7805 compound NF-κB,activation
R6411 T7805 T7801 pobj activation,for
R6412 T7806 T7773 punct .,demonstrated
R6413 T7807 T7810 det The,mutation
R6414 T7808 T7810 nmod Sharpin,mutation
R6415 T7809 T7810 amod null,mutation
R6416 T7810 T7811 nsubj mutation,disrupts
R6417 T7811 T7811 ROOT disrupts,disrupts
R6418 T7812 T7814 det the,process
R6419 T7813 T7814 compound ubiquitylation,process
R6420 T7814 T7811 dobj process,disrupts
R6421 T7815 T7811 cc and,disrupts
R6422 T7816 T7811 conj abrogates,disrupts
R6423 T7817 T7819 det the,NF-κB
R6424 T7818 T7819 amod TNFα-induced,NF-κB
R6425 T7819 T7820 nsubj NF-κB,signaling
R6426 T7820 T7816 ccomp signaling,abrogates
R6427 T7821 T7820 dobj pathway,signaling
R6428 T7822 T7811 punct .,disrupts
R6429 T7823 T7828 mark Since,share
R6430 T7824 T7828 nsubj TNFR,share
R6431 T7825 T7824 cc and,TNFR
R6432 T7826 T7824 conj TLR,TNFR
R6433 T7827 T7828 advmod partially,share
R6434 T7828 T7839 advcl share,hold
R6435 T7829 T7832 poss their,cascades
R6436 T7830 T7832 amod downstream,cascades
R6437 T7831 T7832 compound signaling,cascades
R6438 T7832 T7828 dobj cascades,share
R6439 T7833 T7839 punct ",",hold
R6440 T7834 T7837 det a,regulation
R6441 T7835 T7837 amod similar,regulation
R6442 T7836 T7837 amod ubiquitin-mediated,regulation
R6443 T7837 T7839 nsubj regulation,hold
R6444 T7838 T7839 aux may,hold
R6445 T7839 T7839 ROOT hold,hold
R6446 T7840 T7839 acomp true,hold
R6447 T7841 T7839 prep for,hold
R6448 T7842 T7841 pobj SHARPIN,for
R6449 T7843 T7839 prep in,hold
R6450 T7844 T7843 pobj LPS,in
R6451 T7845 T7839 punct -,hold
R6452 T7846 T7839 cc and,hold
R6453 T7847 T7839 conj poly,hold
R6454 T7848 T7847 nsubj I,poly
R6455 T7849 T7847 punct :,poly
R6456 T7850 T7852 amod C-induced,activation
R6457 T7851 T7852 amod NF-κB,activation
R6458 T7852 T7847 appos activation,poly
R6459 T7853 T7839 punct .,hold
R6460 T7854 T7860 prep In,identified
R6461 T7855 T7854 pobj summary,In
R6462 T7856 T7860 punct ",",identified
R6463 T7857 T7859 det the,study
R6464 T7858 T7859 amod present,study
R6465 T7859 T7860 nsubj study,identified
R6466 T7860 T7860 ROOT identified,identified
R6467 T7861 T7863 det an,role
R6468 T7862 T7863 amod indispensible,role
R6469 T7863 T7860 dobj role,identified
R6470 T7864 T7863 prep of,role
R6471 T7865 T7864 pobj SHARPIN,of
R6472 T7866 T7863 prep in,role
R6473 T7867 T7868 det the,production
R6474 T7868 T7866 pobj production,in
R6475 T7869 T7868 prep of,production
R6476 T7870 T7871 amod pro-inflammatory,mediators
R6477 T7871 T7869 pobj mediators,of
R6478 T7872 T7871 cc and,mediators
R6479 T7873 T7874 amod TLR-induced,NF-κB
R6480 T7874 T7871 conj NF-κB,mediators
R6481 T7875 T7860 advcl signaling,identified
R6482 T7876 T7860 punct .,identified
R6483 T7877 T7880 det The,ability
R6484 T7878 T7880 amod impaired,ability
R6485 T7879 T7880 compound Th1-stimulating,ability
R6486 T7880 T7885 nsubj ability,account
R6487 T7881 T7880 prep of,ability
R6488 T7882 T7883 amod Sharpin-deficient,DC
R6489 T7883 T7881 pobj DC,of
R6490 T7884 T7885 aux may,account
R6491 T7885 T7885 ROOT account,account
R6492 T7886 T7885 prep for,account
R6493 T7887 T7890 det the,phenotype
R6494 T7888 T7890 amod Th2-dominant,phenotype
R6495 T7889 T7890 amod inflammatory,phenotype
R6496 T7890 T7886 pobj phenotype,for
R6497 T7891 T7890 prep of,phenotype
R6498 T7892 T7893 compound cpdm,mice
R6499 T7893 T7891 pobj mice,of
R6500 T7894 T7885 punct .,account
R6501 T7895 T7896 det The,balance
R6502 T7896 T7902 nsubj balance,is
R6503 T7897 T7896 prep between,balance
R6504 T7898 T7897 pobj Th1,between
R6505 T7899 T7898 cc and,Th1
R6506 T7900 T7898 conj Th2,Th1
R6507 T7901 T7902 nsubj differentiation,is
R6508 T7902 T7902 ROOT is,is
R6509 T7903 T7902 acomp critical,is
R6510 T7904 T7903 prep for,critical
R6511 T7905 T7906 amod immune,homeostasis
R6512 T7906 T7904 pobj homeostasis,for
R6513 T7907 T7902 punct .,is
R6514 T7908 T7910 det A,understanding
R6515 T7909 T7910 amod better,understanding
R6516 T7910 T7918 nsubj understanding,help
R6517 T7911 T7910 prep of,understanding
R6518 T7912 T7916 advmod how,maintained
R6519 T7913 T7914 amod such,balance
R6520 T7914 T7916 nsubjpass balance,maintained
R6521 T7915 T7916 auxpass is,maintained
R6522 T7916 T7918 acomp maintained,help
R6523 T7917 T7918 aux will,help
R6524 T7918 T7918 ROOT help,help
R6525 T7919 T7918 xcomp design,help
R6526 T7920 T7921 compound cytokine,treatment
R6527 T7921 T7919 dobj treatment,design
R6528 T7922 T7921 prep for,treatment
R6529 T7923 T7924 amod human,diseases
R6530 T7924 T7922 pobj diseases,for
R6531 T7925 T7921 prep with,treatment
R6532 T7926 T7928 amod Th2-biased,secretion
R6533 T7927 T7928 compound cytokine,secretion
R6534 T7928 T7925 pobj secretion,with
R6535 T7929 T7928 amod similar,secretion
R6536 T7930 T7929 prep to,similar
R6537 T7931 T7933 det the,cpdm
R6538 T7932 T7933 compound mouse,cpdm
R6539 T7933 T7930 pobj cpdm,to
R6540 T7934 T7933 punct ",",cpdm
R6541 T7935 T7936 amod such,as
R6542 T7936 T7929 prep as,similar
R6543 T7937 T7936 pobj allergies,as
R6544 T7938 T7937 cc and,allergies
R6545 T7939 T7940 amod hypereosinophilic,syndromes
R6546 T7940 T7937 conj syndromes,allergies
R6547 T7941 T7918 punct .,help
R5447 T6841 T6841 ROOT diminished,diminished
R5448 T6842 T6843 det the,capacity
R5449 T6843 T6841 dobj capacity,diminished
R5450 T6844 T6843 prep of,capacity
R5451 T6845 T6844 pobj BMDC,of
R5452 T6846 T6847 aux to,secrete
R5453 T6847 T6841 advcl secrete,diminished
R5454 T6848 T6849 amod inflammatory,cytokines
R5455 T6849 T6847 dobj cytokines,secrete
R5456 T6850 T6849 cc and,cytokines
R5457 T6851 T6852 amod nitric,oxide
R5458 T6852 T6849 conj oxide,cytokines
R5767 T7161 T7162 nummod Th1,differentiation
R5768 T7162 T7160 dobj differentiation,polarized
R5769 T7163 T7160 punct ",",polarized
R5770 T7164 T7157 cc but,stimulated
R5771 T7165 T7166 advmod strongly,supported
R5772 T7166 T7157 conj supported,stimulated
R5773 T7167 T7168 det the,development
R5774 T7168 T7166 dobj development,supported
R5775 T7169 T7168 prep of,development
R5776 T7170 T7172 amod Th2,cells
R5777 T7171 T7172 compound effector,cells
R5778 T7172 T7169 pobj cells,of
R5779 T7173 T7157 punct .,stimulated
R5780 T7174 T7193 advcl Combined,suggests
R5781 T7175 T7174 prep with,Combined
R5782 T7176 T7178 det the,effect
R5783 T7177 T7178 amod dramatic,effect
R5784 T7178 T7175 pobj effect,with
R5785 T7179 T7178 prep of,effect
R5786 T7180 T7181 nummod IL12,treatment
R5787 T7181 T7179 pobj treatment,of
R5788 T7182 T7181 prep on,treatment
R5789 T7183 T7184 det the,phenotype
R5790 T7184 T7182 pobj phenotype,on
R5791 T7185 T7184 prep of,phenotype
R5792 T7186 T7187 det these,mice
R5793 T7187 T7185 pobj mice,of
R5794 T7188 T7190 nmod [,]
R5795 T7189 T7190 nummod 5,]
R5796 T7190 T7174 nsubj ],Combined
R5797 T7191 T7190 punct ",",]
R5798 T7192 T7193 nsubj this,suggests
R5799 T7193 T7193 ROOT suggests,suggests
R5800 T7194 T7203 mark that,caused
R5801 T7195 T7198 det the,inflammation
R5802 T7196 T7198 amod Th2-biased,inflammation
R5803 T7197 T7198 amod systemic,inflammation
R5677 T7071 T7071 ROOT is,is
R5678 T7072 T7074 det a,feature
R5679 T7073 T7074 amod prominent,feature
R5680 T7074 T7071 attr feature,is
R5681 T7075 T7074 prep of,feature
R5682 T7076 T7078 det the,lesions
R5683 T7077 T7078 compound skin,lesions
R5684 T7078 T7075 pobj lesions,of
R5685 T7079 T7078 prep in,lesions
R5686 T7080 T7081 compound cpdm,mice
R5687 T7081 T7079 pobj mice,in
R5688 T7082 T7084 nmod [,]
R5689 T7083 T7084 nummod 33,]
R5690 T7084 T7078 conj ],lesions
R5691 T7085 T7084 cc and,]
R5692 T7086 T7088 nsubjpass this,mediated
R5693 T7087 T7088 auxpass is,mediated
R5694 T7088 T7071 advcl mediated,is
R5720 T7114 T7104 prep by,release
R5721 T7115 T7114 pcomp activating,by
R5722 T7116 T7115 dobj DC,activating
R5723 T7117 T7115 prep through,activating
R5724 T7118 T7119 compound pattern,recognition
R5725 T7119 T7120 compound recognition,receptors
R5726 T7120 T7117 pobj receptors,through
R5728 T7122 T7123 nummod 32,]
R5729 T7123 T7120 appos ],receptors
R5730 T7124 T7123 punct ",",]
R5731 T7125 T7127 nmod [,]
R5732 T7126 T7127 nummod 35,]
R5733 T7127 T7123 conj ],]
R5734 T7128 T7127 punct ",",]
R5735 T7129 T7130 amod such,as
R5736 T7130 T7127 prep as,]
R5737 T7131 T7130 pobj HMGB1,as
R5738 T7132 T7104 advcl recognized,release
R5739 T7133 T7132 agent by,recognized
R5740 T7134 T7137 nummod TLR2/4,]
R5741 T7135 T7137 nmod [,]
R5742 T7136 T7137 nummod 36,]
R5743 T7137 T7133 pobj ],by
R5744 T7138 T7137 punct ",",]
R5745 T7139 T7141 nmod [,]
R5746 T7140 T7141 nummod 37,]
R5747 T7141 T7137 appos ],]
R5748 T7142 T7104 punct .,release
R5749 T7143 T7157 advmod Consistent,stimulated
R5750 T7144 T7143 prep with,Consistent
R5751 T7145 T7149 det the,response
R5752 T7146 T7149 amod impaired,response
R5753 T7147 T7149 nmod Th1,response
R5754 T7148 T7149 amod immune,response
R5755 T7149 T7144 pobj response,with
R5756 T7150 T7149 prep in,response
R5757 T7151 T7152 compound cpdm,mice
R5758 T7152 T7150 pobj mice,in
R5759 T7153 T7155 nmod [,]
R5760 T7154 T7155 nummod 5,]
R5761 T7155 T7157 nsubj ],stimulated
R5762 T7156 T7157 punct ",",stimulated
R5763 T7157 T7157 ROOT stimulated,stimulated
R5764 T7158 T7157 dobj BMDC,stimulated
R5765 T7159 T7160 advmod weakly,polarized
R5766 T7160 T7157 conj polarized,stimulated
R5804 T7198 T7203 nsubjpass inflammation,caused
R5805 T7199 T7198 prep in,inflammation
R5806 T7200 T7201 compound cpdm,mice
R5808 T7202 T7203 auxpass is,caused
R5809 T7203 T7193 ccomp caused,suggests
R5810 T7204 T7203 agent by,caused
R5811 T7205 T7207 amod reduced,production
R5812 T7206 T7207 compound IL12P70,production
R5813 T7207 T7204 pobj production,by
R5814 T7208 T7207 prep from,production
R5815 T7209 T7208 pobj DC,from
R5816 T7210 T7193 punct .,suggests
R5817 T7211 T7212 det The,importance
R5818 T7212 T7226 nsubjpass importance,demonstrated
R5819 T7213 T7212 prep of,importance
R5820 T7214 T7213 pobj IL12P70,of
R5821 T7215 T7212 prep in,importance
R5822 T7216 T7215 pcomp regulating,in
R5823 T7217 T7221 nmod Th1,responses
R5824 T7218 T7217 cc and,Th1
R5825 T7219 T7217 conj Th2,Th1
R5826 T7220 T7221 amod immune,responses
R5827 T7221 T7216 dobj responses,regulating
R5828 T7222 T7221 prep in,responses
R5829 T7223 T7222 pobj mice,in
R5830 T7224 T7226 auxpass was,demonstrated
R5831 T7225 T7226 advmod clearly,demonstrated
R5832 T7226 T7226 ROOT demonstrated,demonstrated
R5833 T7227 T7226 prep in,demonstrated
R5834 T7228 T7227 pobj IL12P35,in
R6384 T7778 T7777 pobj HOIP,with
R6385 T7779 T7780 aux to,form
R6386 T7780 T7776 advcl form,interacts
R6387 T7781 T7780 dobj LUBAC,form
R6388 T7782 T7783 nsubj that,exerts
R6389 T7783 T7781 relcl exerts,LUBAC
R6390 T7784 T7786 poss its,activity
R6391 T7785 T7786 amod linear-ubiquitin-chain-ligase,activity
R6392 T7786 T7783 dobj activity,exerts

UBERON-AE

Id Subject Object Predicate Lexical cue
T6671 1210-1216 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organs
T6672 1271-1276 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organ
T6673 1221-1228 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
T6674 3293-3300 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
T6675 3351-3357 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T6676 3437-3443 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T6677 4078-4084 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T6678 4135-4141 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T6679 3773-3784 http://purl.obolibrary.org/obo/UBERON_0000353 denotes parenchymal
T6680 4026-4037 http://purl.obolibrary.org/obo/UBERON_0000353 denotes parenchymal
T6681 3804-3809 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T6682 3815-3824 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestine

GO-BP

Id Subject Object Predicate Lexical cue
T9123 158-169 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T9124 777-788 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T9125 2202-2213 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T9126 4602-4613 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T9127 331-350 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T9128 476-485 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T9129 2679-2688 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T9130 3011-3020 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T9131 3470-3479 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T9132 4526-4535 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T9133 5437-5446 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T9134 5598-5607 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T9135 5786-5795 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T9136 5985-5994 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T9137 6056-6065 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T9138 6333-6342 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T9139 905-917 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T9140 1156-1168 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T9141 2368-2380 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T9142 3612-3624 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T9143 3844-3856 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T9144 1113-1134 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T9145 1419-1429 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T9146 1613-1623 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T9147 1424-1429 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T9148 1618-1623 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T9149 1613-1631 http://purl.obolibrary.org/obo/GO_0043276 denotes cell death-induced
T9150 1613-1631 http://purl.obolibrary.org/obo/GO_0071888 denotes cell death-induced
T9151 1654-1663 http://purl.obolibrary.org/obo/GO_0006915 denotes Apoptosis
T9152 1654-1663 http://purl.obolibrary.org/obo/GO_0097194 denotes Apoptosis
T9153 1654-1680 http://purl.obolibrary.org/obo/GO_0097283 denotes Apoptosis of keratinocytes
T9154 2083-2102 http://purl.obolibrary.org/obo/GO_0042088 denotes Th1 immune response
T9155 2087-2102 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T9156 2495-2511 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T9157 2491-2511 http://purl.obolibrary.org/obo/GO_0042092 denotes Th2 immune responses
T9158 2491-2511 http://purl.obolibrary.org/obo/GO_0002828 denotes Th2 immune responses
T9159 2674-2678 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T9160 2955-2959 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T9161 2966-2969 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T9162 2674-2688 http://purl.obolibrary.org/obo/GO_0000165 denotes MAPK signaling
T9163 2817-2833 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T9164 3165-3181 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T9165 3753-3769 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T9166 4271-4287 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T9167 4949-4965 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T9168 5217-5233 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T9169 5467-5483 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T9170 5868-5884 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T9171 6171-6187 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T9172 2944-2948 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T9173 3190-3203 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T9174 4078-4096 http://purl.obolibrary.org/obo/GO_0001894 denotes tissue homeostasis
T9175 4085-4096 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T9176 4856-4867 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T9177 6546-6557 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T9178 4526-4543 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T9179 5985-6002 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T9180 6056-6074 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling cascades
T9181 4839-4849 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T9182 6105-6115 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T9183 4853-4867 http://purl.obolibrary.org/obo/GO_0036145 denotes DC homeostasis
T9184 5761-5776 http://purl.obolibrary.org/obo/GO_0016874 denotes ligase activity
T9185 6086-6115 http://purl.obolibrary.org/obo/GO_2000395 denotes ubiquitin-mediated regulation
T9186 6687-6705 http://purl.obolibrary.org/obo/GO_0050663 denotes cytokine secretion
T9187 6696-6705 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion

GO-MF

Id Subject Object Predicate Lexical cue
T9190 2674-2678 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T9191 2955-2959 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T9192 2966-2969 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T9193 2944-2948 http://purl.obolibrary.org/obo/GO_0008384 denotes TBK1
T9194 5044-5051 http://purl.obolibrary.org/obo/GO_0005488 denotes ligands
T9195 5745-5754 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T9196 6086-6095 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T9197 5761-5776 http://purl.obolibrary.org/obo/GO_0016874 denotes ligase activity
T9188 1965-1994 http://purl.obolibrary.org/obo/GO_0038187 denotes pattern recognition receptors

GO-CC

Id Subject Object Predicate Lexical cue
T9198 531-535 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T9199 1419-1423 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T9200 1613-1617 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T9201 3341-3345 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T9202 4125-4129 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T9203 4740-4745 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9204 5291-5296 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T6766 11-192 Sentence denotes The present report showed that null mutations of the mouse Sharpin gene did not affect the steady-state distribution of splenic DC subsets nor the development and phenotype of BMDC.
T6767 193-315 Sentence denotes However, loss of SHARPIN significantly diminished the capacity of BMDC to secrete inflammatory cytokines and nitric oxide.
T6768 316-486 Sentence denotes The attenuated cytokine production was not due to the presence of anti-inflammatory inhibitors, and can be largely explained by selective inactivation of NF-κB signaling.
T6769 487-626 Sentence denotes Stimulated cpdm BMDC exhibited Th2-biased T cell-polarizing capabilities, consistent with the Th2 cytokine-dominant phenotype in cpdm mice.
T6770 627-808 Sentence denotes Together, these results indicate an indispensible role of SHARPIN in regulating DC immunological functions, disruption of which may contribute to the development of immune diseases.
T6771 809-946 Sentence denotes Since WT and cpdm mice are both specific pathogen-free, the nature of the trigger of the severe inflammation in cpdm mice is not obvious.
T6772 947-1140 Sentence denotes One such initiating factor could be endogenous apoptotic and/or necrotic cells that can release danger-associated molecular patterns (DAMPs) to launch and amplify an inflammatory response [32].
T6773 1141-1300 Sentence denotes Such ‘sterile’ inflammation could be initiated and take place in all organs and tissues affected in cpdm mice, thus causing multi-organ inflammatory disorders.
T6774 1301-1356 Sentence denotes This hypothesis is supported by several recent studies.
T6775 1357-1653 Sentence denotes Fibroblasts of cpdm mice are highly sensitive to TNFα-induced cell death and the cpdm phenotype can be partially rescued by deletion of TNF [7], [8], suggesting that deficiency of SHARPIN compromises the anti-apoptotic mechanisms in cpdm mice resulting in cell death-induced inflammatory disease.
T6776 1654-1812 Sentence denotes Apoptosis of keratinocytes is a prominent feature of the skin lesions in cpdm mice [33] and this is mediated by caspase-dependent mitochondrial pathways [34].
T6777 1813-2053 Sentence denotes These induced and/or intrinsic apoptotic cells can release various types of DAMPs that exert their pro-inflammatory properties by activating DC through pattern recognition receptors [32], [35], such as HMGB1 recognized by TLR2/4 [36], [37].
T6778 2054-2236 Sentence denotes Consistent with the impaired Th1 immune response in cpdm mice [5], stimulated BMDC weakly polarized Th1 differentiation, but strongly supported the development of Th2 effector cells.
T6779 2237-2442 Sentence denotes Combined with the dramatic effect of IL12 treatment on the phenotype of these mice [5], this suggests that the Th2-biased systemic inflammation in cpdm mice is caused by reduced IL12P70 production from DC.
T6780 2443-2652 Sentence denotes The importance of IL12P70 in regulating Th1 and Th2 immune responses in mice was clearly demonstrated in IL12P35- and IL12P40-deficient mice [38], [39] and through clinical studies in human patients [40]–[42].
T6781 2653-2816 Sentence denotes NF-κB, TBK/IRF3, and MAPK signaling are important pathways activated by LPS or poly I:C and disruption of either pathway may lead to decreased cytokine expression.
T6782 2817-3085 Sentence denotes NF-κB activation was selectively inhibited in LPS and poly I:C stimulated cpdm BMDC compared to wild type, while activation of TBK1/IRF3, ERK1/2, or p38 was not, indicating that disrupted NF-κB signaling in cpdm DC is responsible for the defective cytokine expression.
T6783 3086-3222 Sentence denotes These results seem to contradict a recent study that found increased levels of NF-κB activation and IL1 transcription in cpdm mice [43].
T6784 3223-3394 Sentence denotes This difference can probably be attributed to the different cells and tissues used in these studies, and may point to cell- and tissue- type specific functions of SHARPIN.
T6785 3395-3485 Sentence denotes This is consistent with recent reports of tissue-specific effects of NF-κB signaling [44].
T6786 3486-3719 Sentence denotes Ubiquitous activation of NF-κB by removing inhibitors such as A20 and ITCH through genetic manipulation results in widespread inflammation, consistent with the role of NF-κB in the production of pro-inflammatory mediators [45], [46].
T6787 3720-3904 Sentence denotes However, selective inhibition of NF-κB activation in parenchymal cells of the skin, liver, and intestine results in chronic inflammation driven by NF-κB competent leukocytes [47]–[50].
T6788 3905-4097 Sentence denotes This indicates that a balance between the pro-inflammatory role of NF-κB in leukocytes and the anti-inflammatory role in parenchymal cells is critical in the maintenance of tissue homeostasis.
T6789 4098-4252 Sentence denotes Experiments with mice with cell- and tissue-specific deletion of Sharpin, currently under way, will help to elucidate the role of SHARPIN in inflammation.
T6790 4253-4434 Sentence denotes Despite defective NF-κB activation in the absence of Sharpin expression, there was no significant change in splenic DC populations or expression of co-stimulatory molecules on BMDC.
T6791 4435-4638 Sentence denotes Different NF-κB subunits involved in the canonical and non-canonical branches of the NF-κB signaling pathway have distinct functions to control specific aspects of DC development and function [51], [52].
T6792 4639-4883 Sentence denotes The non-canonical pathway (p100 processing to produce p52) appears to be intact in SHARPIN-deficient cells [7], [9] suggesting that the NF-κB heterodimer p52/RELB is sufficient to maintain the normal regulation of DC homeostasis and maturation.
T6793 4884-4999 Sentence denotes The molecular basis by which the Sharpin mutation causes reduced NF-κB activation in BMDC remains to be determined.
T6794 5000-5105 Sentence denotes LPS and poly I:C used here are well-defined ligands that specifically engage TLR4 and TLR3, respectively.
T6795 5106-5297 Sentence denotes The expression profile of surface TLR4 complexes is similar between WT and cpdm BMDC suggesting that defective NF-κB activation is not a result of differential TLR expression on target cells.
T6796 5298-5452 Sentence denotes LPS engages TLR4 to activate MYD88-dependent and TRIF-dependent pathways, whereas TLR3 stimulated by poly I:C only triggers TRIF-dependent signaling [53].
T6797 5453-5646 Sentence denotes The defective NF-κB activation by both stimuli suggests that the Sharpin mutation interferes with the protein adaptors or kinases shared by both signaling pathways, such as RIP1 and TRAF6 [18].
T6798 5647-5885 Sentence denotes Recent studies demonstrated that SHARPIN interacts with HOIP to form LUBAC that exerts its linear-ubiquitin-chain-ligase activity on NF-κB signaling players RIP1 and NEMO [7], an essential step for intact TNFα-stimulated NF-κB activation.
T6799 5886-6003 Sentence denotes The Sharpin null mutation disrupts the ubiquitylation process and abrogates the TNFα-induced NF-κB signaling pathway.
T6800 6004-6188 Sentence denotes Since TNFR and TLR partially share their downstream signaling cascades, a similar ubiquitin-mediated regulation may hold true for SHARPIN in LPS- and poly I:C-induced NF-κB activation.
T6801 6189-6343 Sentence denotes In summary, the present study identified an indispensible role of SHARPIN in the production of pro-inflammatory mediators and TLR-induced NF-κB signaling.
T6802 6344-6474 Sentence denotes The impaired Th1-stimulating ability of Sharpin-deficient DC may account for the Th2-dominant inflammatory phenotype of cpdm mice.
T6803 6475-6558 Sentence denotes The balance between Th1 and Th2 differentiation is critical for immune homeostasis.
T6804 6559-6783 Sentence denotes A better understanding of how such balance is maintained will help design cytokine treatment for human diseases with Th2-biased cytokine secretion similar to the mouse cpdm, such as allergies and hypereosinophilic syndromes.
T130 0-10 Sentence denotes Discussion
T131 11-192 Sentence denotes The present report showed that null mutations of the mouse Sharpin gene did not affect the steady-state distribution of splenic DC subsets nor the development and phenotype of BMDC.
T132 193-315 Sentence denotes However, loss of SHARPIN significantly diminished the capacity of BMDC to secrete inflammatory cytokines and nitric oxide.
T133 316-486 Sentence denotes The attenuated cytokine production was not due to the presence of anti-inflammatory inhibitors, and can be largely explained by selective inactivation of NF-κB signaling.
T134 487-626 Sentence denotes Stimulated cpdm BMDC exhibited Th2-biased T cell-polarizing capabilities, consistent with the Th2 cytokine-dominant phenotype in cpdm mice.
T135 627-808 Sentence denotes Together, these results indicate an indispensible role of SHARPIN in regulating DC immunological functions, disruption of which may contribute to the development of immune diseases.
T136 809-946 Sentence denotes Since WT and cpdm mice are both specific pathogen-free, the nature of the trigger of the severe inflammation in cpdm mice is not obvious.
T137 947-1140 Sentence denotes One such initiating factor could be endogenous apoptotic and/or necrotic cells that can release danger-associated molecular patterns (DAMPs) to launch and amplify an inflammatory response [32].
T138 1141-1300 Sentence denotes Such ‘sterile’ inflammation could be initiated and take place in all organs and tissues affected in cpdm mice, thus causing multi-organ inflammatory disorders.
T139 1301-1356 Sentence denotes This hypothesis is supported by several recent studies.
T140 1357-1653 Sentence denotes Fibroblasts of cpdm mice are highly sensitive to TNFα-induced cell death and the cpdm phenotype can be partially rescued by deletion of TNF [7], [8], suggesting that deficiency of SHARPIN compromises the anti-apoptotic mechanisms in cpdm mice resulting in cell death-induced inflammatory disease.
T141 1654-1812 Sentence denotes Apoptosis of keratinocytes is a prominent feature of the skin lesions in cpdm mice [33] and this is mediated by caspase-dependent mitochondrial pathways [34].
T142 1813-2053 Sentence denotes These induced and/or intrinsic apoptotic cells can release various types of DAMPs that exert their pro-inflammatory properties by activating DC through pattern recognition receptors [32], [35], such as HMGB1 recognized by TLR2/4 [36], [37].
T143 2054-2236 Sentence denotes Consistent with the impaired Th1 immune response in cpdm mice [5], stimulated BMDC weakly polarized Th1 differentiation, but strongly supported the development of Th2 effector cells.
T144 2237-2442 Sentence denotes Combined with the dramatic effect of IL12 treatment on the phenotype of these mice [5], this suggests that the Th2-biased systemic inflammation in cpdm mice is caused by reduced IL12P70 production from DC.
T145 2443-2652 Sentence denotes The importance of IL12P70 in regulating Th1 and Th2 immune responses in mice was clearly demonstrated in IL12P35- and IL12P40-deficient mice [38], [39] and through clinical studies in human patients [40]–[42].
T146 2653-2816 Sentence denotes NF-κB, TBK/IRF3, and MAPK signaling are important pathways activated by LPS or poly I:C and disruption of either pathway may lead to decreased cytokine expression.
T147 2817-3085 Sentence denotes NF-κB activation was selectively inhibited in LPS and poly I:C stimulated cpdm BMDC compared to wild type, while activation of TBK1/IRF3, ERK1/2, or p38 was not, indicating that disrupted NF-κB signaling in cpdm DC is responsible for the defective cytokine expression.
T148 3086-3222 Sentence denotes These results seem to contradict a recent study that found increased levels of NF-κB activation and IL1 transcription in cpdm mice [43].
T149 3223-3394 Sentence denotes This difference can probably be attributed to the different cells and tissues used in these studies, and may point to cell- and tissue- type specific functions of SHARPIN.
T150 3395-3485 Sentence denotes This is consistent with recent reports of tissue-specific effects of NF-κB signaling [44].
T151 3486-3719 Sentence denotes Ubiquitous activation of NF-κB by removing inhibitors such as A20 and ITCH through genetic manipulation results in widespread inflammation, consistent with the role of NF-κB in the production of pro-inflammatory mediators [45], [46].
T152 3720-3904 Sentence denotes However, selective inhibition of NF-κB activation in parenchymal cells of the skin, liver, and intestine results in chronic inflammation driven by NF-κB competent leukocytes [47]–[50].
T153 3905-4097 Sentence denotes This indicates that a balance between the pro-inflammatory role of NF-κB in leukocytes and the anti-inflammatory role in parenchymal cells is critical in the maintenance of tissue homeostasis.
T154 4098-4252 Sentence denotes Experiments with mice with cell- and tissue-specific deletion of Sharpin, currently under way, will help to elucidate the role of SHARPIN in inflammation.
T155 4253-4434 Sentence denotes Despite defective NF-κB activation in the absence of Sharpin expression, there was no significant change in splenic DC populations or expression of co-stimulatory molecules on BMDC.
T156 4435-4638 Sentence denotes Different NF-κB subunits involved in the canonical and non-canonical branches of the NF-κB signaling pathway have distinct functions to control specific aspects of DC development and function [51], [52].
T157 4639-4883 Sentence denotes The non-canonical pathway (p100 processing to produce p52) appears to be intact in SHARPIN-deficient cells [7], [9] suggesting that the NF-κB heterodimer p52/RELB is sufficient to maintain the normal regulation of DC homeostasis and maturation.
T158 4884-4999 Sentence denotes The molecular basis by which the Sharpin mutation causes reduced NF-κB activation in BMDC remains to be determined.
T159 5000-5105 Sentence denotes LPS and poly I:C used here are well-defined ligands that specifically engage TLR4 and TLR3, respectively.
T160 5106-5297 Sentence denotes The expression profile of surface TLR4 complexes is similar between WT and cpdm BMDC suggesting that defective NF-κB activation is not a result of differential TLR expression on target cells.
T161 5298-5452 Sentence denotes LPS engages TLR4 to activate MYD88-dependent and TRIF-dependent pathways, whereas TLR3 stimulated by poly I:C only triggers TRIF-dependent signaling [53].
T162 5453-5646 Sentence denotes The defective NF-κB activation by both stimuli suggests that the Sharpin mutation interferes with the protein adaptors or kinases shared by both signaling pathways, such as RIP1 and TRAF6 [18].
T163 5647-5885 Sentence denotes Recent studies demonstrated that SHARPIN interacts with HOIP to form LUBAC that exerts its linear-ubiquitin-chain-ligase activity on NF-κB signaling players RIP1 and NEMO [7], an essential step for intact TNFα-stimulated NF-κB activation.
T164 5886-6003 Sentence denotes The Sharpin null mutation disrupts the ubiquitylation process and abrogates the TNFα-induced NF-κB signaling pathway.
T165 6004-6188 Sentence denotes Since TNFR and TLR partially share their downstream signaling cascades, a similar ubiquitin-mediated regulation may hold true for SHARPIN in LPS- and poly I:C-induced NF-κB activation.
T166 6189-6343 Sentence denotes In summary, the present study identified an indispensible role of SHARPIN in the production of pro-inflammatory mediators and TLR-induced NF-κB signaling.
T167 6344-6474 Sentence denotes The impaired Th1-stimulating ability of Sharpin-deficient DC may account for the Th2-dominant inflammatory phenotype of cpdm mice.
T168 6475-6558 Sentence denotes The balance between Th1 and Th2 differentiation is critical for immune homeostasis.
T169 6559-6783 Sentence denotes A better understanding of how such balance is maintained will help design cytokine treatment for human diseases with Th2-biased cytokine secretion similar to the mouse cpdm, such as allergies and hypereosinophilic syndromes.

ICD10

Id Subject Object Predicate Lexical cue
T9189 6741-6750 http://purl.bioontology.org/ontology/ICD10/T78.4 denotes allergies

events-check-again

Id Subject Object Predicate Lexical cue Negation
T9371 42-56 Negative_regulation denotes null mutations
T9372 70-77 Protein denotes Sharpin
T9373 202-206 Negative_regulation denotes loss
T9374 210-217 Protein denotes SHARPIN
T9375 685-692 Protein denotes SHARPIN
T9376 735-745 Negative_regulation denotes disruption
T9377 1406-1410 Protein denotes TNFα
T9378 1481-1489 Negative_regulation denotes deletion
T9379 1493-1496 Protein denotes TNF
T9380 1523-1533 Negative_regulation denotes deficiency
T9381 1537-1544 Protein denotes SHARPIN
T9382 2015-2020 Protein denotes HMGB1
T9383 2021-2031 Binding denotes recognized
T9384 2035-2039 Protein denotes TLR2
T9385 2040-2041 Protein denotes 4
T9386 2548-2555 Protein denotes IL12P35
T9387 2561-2568 Protein denotes IL12P40
T9388 2569-2578 Negative_regulation denotes deficient
T9389 2569-2578 Negative_regulation denotes deficient
T9390 2664-2668 Protein denotes IRF3
T9391 2930-2940 Positive_regulation denotes activation
T9392 2930-2940 Positive_regulation denotes activation
T9393 2930-2940 Positive_regulation denotes activation
T9394 2930-2940 Positive_regulation denotes activation
T9395 2944-2948 Protein denotes TBK1
T9396 2949-2953 Protein denotes IRF3
T9397 2955-2959 Protein denotes ERK1
T9398 2960-2961 Protein denotes 2
T9399 2970-2977 Negative_regulation denotes was not true
T9400 2970-2977 Negative_regulation denotes was not true
T9401 2970-2977 Negative_regulation denotes was not true
T9402 2970-2977 Negative_regulation denotes was not true
T9403 3386-3393 Protein denotes SHARPIN
T9404 3548-3551 Protein denotes A20
T9405 3556-3560 Protein denotes ITCH
T9406 4151-4159 Negative_regulation denotes deletion
T9407 4163-4170 Protein denotes Sharpin
T9408 4228-4235 Protein denotes SHARPIN
T9409 4295-4302 Negative_regulation denotes absence
T9410 4306-4313 Protein denotes Sharpin
T9411 4314-4324 Gene_expression denotes expression
T9412 4666-4670 Protein denotes p100
T9413 4693-4696 Protein denotes p52
T9414 4722-4729 Protein denotes SHARPIN
T9415 4730-4739 Negative_regulation denotes deficient
T9416 4793-4796 Protein denotes p52
T9417 4797-4801 Protein denotes RELB
T9418 4917-4924 Protein denotes Sharpin
T9419 4925-4933 Negative_regulation denotes mutation
T9420 5070-5076 Binding denotes engage
T9421 5070-5076 Binding denotes engage
T9422 5077-5081 Protein denotes TLR4
T9423 5086-5090 Protein denotes TLR3
T9424 5302-5309 Binding denotes engages
T9425 5310-5314 Protein denotes TLR4
T9426 5327-5332 Protein denotes MYD88
T9427 5347-5351 Protein denotes TRIF
T9428 5380-5384 Protein denotes TLR3
T9429 5385-5395 Positive_regulation denotes stimulated
T9430 5422-5426 Protein denotes TRIF
T9431 5518-5525 Protein denotes Sharpin
T9432 5526-5534 Negative_regulation denotes mutation
T9433 5626-5630 Protein denotes RIP1
T9434 5635-5640 Protein denotes TRAF6
T9435 5680-5687 Protein denotes SHARPIN
T9436 5688-5697 Binding denotes interacts
T9437 5703-5707 Protein denotes HOIP
T9438 5727-5733 Positive_regulation denotes exerts
T9439 5727-5733 Positive_regulation denotes exerts
T9440 5738-5776 Ubiquitination denotes linear-ubiquitin-chain-ligase activity
T9441 5738-5776 Ubiquitination denotes linear-ubiquitin-chain-ligase activity
T9442 5804-5808 Protein denotes RIP1
T9443 5813-5817 Protein denotes NEMO
T9444 5852-5856 Protein denotes TNFα
T9445 5890-5897 Protein denotes Sharpin
T9446 5898-5911 Negative_regulation denotes null mutation
T9447 5912-5920 Negative_regulation denotes disrupts
T9448 5912-5920 Negative_regulation denotes disrupts
T9449 5966-5970 Protein denotes TNFα
T9450 6134-6141 Protein denotes SHARPIN
T9451 6255-6262 Protein denotes SHARPIN
T9452 6384-6391 Protein denotes Sharpin
T9453 6392-6401 Negative_regulation denotes deficient
R7734 T9372 T9371 themeOf Sharpin,null mutations
R7735 T9374 T9373 themeOf SHARPIN,loss
R7736 T9375 T9376 themeOf SHARPIN,disruption
R7739 T9379 T9378 themeOf TNF,deletion
R7740 T9381 T9380 themeOf SHARPIN,deficiency
R7741 T9382 T9383 themeOf HMGB1,recognized
R7743 T9384 T9383 themeOf TLR2,recognized
R7744 T9386 T9389 themeOf IL12P35,deficient
R7745 T9387 T9388 themeOf IL12P40,deficient
R7747 T9391 T9400 themeOf activation,was not
R7748 T9392 T9402 themeOf activation,was not
R7749 T9393 T9399 themeOf activation,was not
R7750 T9394 T9401 themeOf activation,was not
R7751 T9395 T9394 themeOf TBK1,activation
R7753 T9396 T9393 themeOf IRF3,activation
R7754 T9397 T9391 themeOf ERK1,activation
R7755 T9398 T9392 themeOf 2,activation
R7759 T9407 T9406 themeOf Sharpin,deletion
R7761 T9410 T9411 themeOf Sharpin,expression
R7762 T9411 T9409 themeOf expression,absence
R7764 T9414 T9415 themeOf SHARPIN,deficient
R7767 T9418 T9419 themeOf Sharpin,mutation
R7769 T9422 T9420 themeOf TLR4,engage
R7770 T9423 T9421 themeOf TLR3,engage
R7772 T9425 T9424 themeOf TLR4,engages
R7775 T9428 T9429 themeOf TLR3,stimulated
R7777 T9431 T9432 themeOf Sharpin,mutation
R7780 T9435 T9436 themeOf SHARPIN,interacts
R7781 T9435 T9440 causeOf SHARPIN,linear-ubiquitin-chain-ligase activity
R7782 T9435 T9441 causeOf SHARPIN,linear-ubiquitin-chain-ligase activity
R7783 T9437 T9436 themeOf HOIP,interacts
R7785 T9440 T9439 themeOf linear-ubiquitin-chain-ligase activity,exerts
R7786 T9440 T9447 themeOf linear-ubiquitin-chain-ligase activity,disrupts
R7788 T9441 T9438 themeOf linear-ubiquitin-chain-ligase activity,exerts
R7789 T9441 T9448 themeOf linear-ubiquitin-chain-ligase activity,disrupts
R7791 T9442 T9440 themeOf RIP1,linear-ubiquitin-chain-ligase activity
R7792 T9443 T9441 themeOf NEMO,linear-ubiquitin-chain-ligase activity
R7793 T9445 T9446 themeOf Sharpin,null mutation
R7794 T9446 T9447 causeOf null mutation,disrupts
R7795 T9446 T9448 causeOf null mutation,disrupts
R7797 T9452 T9453 themeOf Sharpin,deficient

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T9454 64-82 Protein denotes mouse Sharpin gene
T9455 91-97 Regulation denotes affect
T9456 470-475 Protein denotes NF-κB
T9457 581-584 Protein denotes Th2
T9458 685-692 Protein denotes SHARPIN
T9459 1406-1410 Protein denotes TNFα
T9460 1493-1496 Protein denotes TNF
T9461 1537-1544 Protein denotes SHARPIN
T9462 1523-1533 Negative_regulation denotes deficiency
T9463 1766-1773 Protein denotes caspase
T9464 1889-1894 Protein denotes DAMPs
T9465 2015-2020 Protein denotes HMGB1
T9466 1864-1871 Localization denotes release
T9467 2021-2031 Binding denotes recognized
T9468 2083-2086 Protein denotes Th1
T9469 2154-2157 Protein denotes Th1
T9470 2274-2278 Protein denotes IL12
T9471 2415-2422 Protein denotes IL12P70
T9472 2423-2433 Gene_expression denotes production
T9473 2407-2414 Negative_regulation denotes reduced
T9474 2461-2468 Protein denotes IL12P70
T9475 2548-2568 Protein denotes IL12P35- and IL12P40
T9476 2447-2457 Positive_regulation denotes importance
T9477 2653-2658 Protein denotes NF-κB
T9478 2660-2663 Protein denotes TBK
T9479 2664-2668 Protein denotes IRF3
T9480 2674-2678 Protein denotes MAPK
T9481 2817-2822 Protein denotes NF-κB
T9482 2944-2948 Protein denotes TBK1
T9483 2949-2953 Protein denotes IRF3
T9484 2955-2959 Protein denotes ERK1
T9485 2966-2969 Protein denotes p38
T9486 3005-3010 Protein denotes NF-κB
T9487 2823-2833 Positive_regulation denotes activation
T9488 2850-2859 Negative_regulation denotes inhibited
T9489 2930-2940 Positive_regulation denotes activation
T9490 2930-2940 Positive_regulation denotes activation
T9491 2930-2940 Positive_regulation denotes activation
T9492 2930-2940 Positive_regulation denotes activation
T9493 3165-3170 Protein denotes NF-κB
T9494 3186-3189 Protein denotes IL1
T9495 3171-3181 Positive_regulation denotes activation
T9496 3190-3203 Transcription denotes transcription
T9497 3145-3154 Positive_regulation denotes increased
T9498 3145-3154 Positive_regulation denotes increased
T9499 3171-3181 Positive_regulation denotes activation
T9500 3386-3393 Protein denotes SHARPIN
T9501 3464-3469 Protein denotes NF-κB
T9502 3511-3516 Protein denotes NF-κB
T9503 3654-3659 Protein denotes NF-κB
T9504 3497-3507 Positive_regulation denotes activation
T9505 3753-3758 Protein denotes NF-κB
T9506 3867-3872 Protein denotes NF-κB
T9507 3759-3769 Positive_regulation denotes activation
T9508 3739-3749 Negative_regulation denotes inhibition
T9509 3972-3977 Protein denotes NF-κB
T9510 4163-4170 Protein denotes Sharpin
T9511 4228-4235 Protein denotes SHARPIN
T9512 4271-4276 Protein denotes NF-κB
T9513 4306-4313 Protein denotes Sharpin
T9514 4277-4287 Positive_regulation denotes activation
T9515 4314-4324 Gene_expression denotes expression
T9516 4277-4287 Positive_regulation denotes activation
T9517 4445-4459 Protein denotes NF-κB subunits
T9518 4520-4525 Protein denotes NF-κB
T9519 4693-4696 Protein denotes p52
T9520 4722-4729 Protein denotes SHARPIN
T9521 4775-4780 Protein denotes NF-κB
T9522 4793-4796 Protein denotes p52
T9523 4797-4801 Protein denotes RELB
T9524 4685-4692 Gene_expression denotes produce
T9525 4730-4739 Negative_regulation denotes deficient
T9526 4917-4924 Protein denotes Sharpin
T9527 4949-4954 Protein denotes NF-κB
T9528 5077-5081 Protein denotes TLR4
T9529 5086-5090 Protein denotes TLR3
T9530 5070-5076 Binding denotes engage
T9531 5140-5144 Protein denotes TLR4
T9532 5217-5222 Protein denotes NF-κB
T9533 5266-5269 Protein denotes TLR
T9534 5110-5120 Gene_expression denotes expression
T9535 5223-5233 Positive_regulation denotes activation
T9536 5270-5280 Gene_expression denotes expression
T9537 5310-5314 Protein denotes TLR4
T9538 5327-5332 Protein denotes MYD88
T9539 5347-5351 Protein denotes TRIF
T9540 5380-5384 Protein denotes TLR3
T9541 5422-5426 Protein denotes TRIF
T9542 5302-5309 Positive_regulation denotes engages
T9543 5467-5472 Protein denotes NF-κB
T9544 5518-5525 Protein denotes Sharpin
T9545 5626-5630 Protein denotes RIP1
T9546 5635-5640 Protein denotes TRAF6
T9547 5473-5483 Positive_regulation denotes activation
T9548 5535-5545 Binding denotes interferes
T9549 5535-5545 Binding denotes interferes
T9550 5535-5545 Binding denotes interferes
T9551 5680-5687 Protein denotes SHARPIN
T9552 5745-5754 Protein denotes ubiquitin
T9553 5755-5760 Protein denotes chain
T9554 5761-5767 Protein denotes ligase
T9555 5780-5785 Protein denotes NF-κB
T9556 5804-5808 Protein denotes RIP1
T9557 5852-5870 Protein denotes TNFα-stimulated NF
T9558 5871-5873 Protein denotes κB
T9559 5688-5697 Binding denotes interacts
T9560 5874-5884 Positive_regulation denotes activation
T9561 5874-5884 Positive_regulation denotes activation
T9562 5890-5897 Protein denotes Sharpin
T9563 5966-5970 Protein denotes TNFα
T9564 5979-5984 Protein denotes NF-κB
T9565 6010-6014 Protein denotes TNFR
T9566 6019-6022 Protein denotes TLR
T9567 6134-6141 Protein denotes SHARPIN
T9568 6171-6176 Protein denotes NF-κB
T9569 6177-6187 Positive_regulation denotes activation
T9570 6105-6115 Regulation denotes regulation
T9571 6255-6262 Protein denotes SHARPIN
T9572 6327-6332 Protein denotes NF-κB
T9573 6270-6280 Gene_expression denotes production
T9574 6357-6360 Protein denotes Th1
T9575 6384-6391 Protein denotes Sharpin
T9576 6392-6401 Negative_regulation denotes deficient
R7796 T9454 T9455 themeOf mouse Sharpin gene,affect
R7798 T9543 T9547 themeOf NF-κB,activation
R7799 T9544 T9548 themeOf Sharpin,interferes
R7800 T9544 T9549 themeOf Sharpin,interferes
R7801 T9544 T9550 themeOf Sharpin,interferes
R7802 T9545 T9549 themeOf RIP1,interferes
R7803 T9546 T9550 themeOf TRAF6,interferes
R7804 T9551 T9559 themeOf SHARPIN,interacts
R7805 T9461 T9462 themeOf SHARPIN,deficiency
R7806 T9464 T9466 themeOf DAMPs,release
R7807 T9465 T9467 themeOf HMGB1,recognized
R7808 T9557 T9560 themeOf TNFα-stimulated NF,activation
R7809 T9471 T9472 themeOf IL12P70,production
R7810 T9472 T9473 themeOf production,reduced
R7811 T9474 T9476 themeOf IL12P70,importance
R7812 T9558 T9561 themeOf κB,activation
R7813 T9568 T9569 themeOf NF-κB,activation
R7814 T9481 T9487 themeOf NF-κB,activation
R7815 T9482 T9489 themeOf TBK1,activation
R7816 T9483 T9490 themeOf IRF3,activation
R7817 T9484 T9491 themeOf ERK1,activation
R7818 T9485 T9492 themeOf p38,activation
R7819 T9487 T9488 themeOf activation,inhibited
R7820 T9493 T9495 themeOf NF-κB,activation
R7821 T9494 T9496 themeOf IL1,transcription
R7822 T9569 T9570 themeOf activation,regulation
R7823 T9495 T9497 themeOf activation,increased
R7824 T9496 T9498 themeOf transcription,increased
R7825 T9496 T9499 themeOf transcription,activation
R7826 T9571 T9573 themeOf SHARPIN,production
R7827 T9575 T9576 themeOf Sharpin,deficient
R7828 T9502 T9504 themeOf NF-κB,activation
R7829 T9505 T9507 themeOf NF-κB,activation
R7830 T9507 T9508 themeOf activation,inhibition
R7831 T9512 T9514 themeOf NF-κB,activation
R7832 T9513 T9515 themeOf Sharpin,expression
R7833 T9515 T9516 themeOf expression,activation
R7834 T9519 T9524 themeOf p52,produce
R7835 T9520 T9525 themeOf SHARPIN,deficient
R7836 T9529 T9530 themeOf TLR3,engage
R7837 T9531 T9534 themeOf TLR4,expression
R7838 T9532 T9535 themeOf NF-κB,activation
R7839 T9533 T9536 themeOf TLR,expression
R7840 T9537 T9542 themeOf TLR4,engages

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation
T6684 70-77 Protein denotes Sharpin
T6685 202-206 Negative_regulation denotes loss
T6686 210-217 Protein denotes SHARPIN
T6687 685-692 Protein denotes SHARPIN
T6688 735-745 Negative_regulation denotes disruption
T6689 1406-1410 Protein denotes TNFα
T6690 1481-1489 Negative_regulation denotes deletion
T6691 1493-1496 Protein denotes TNF
T6692 1523-1533 Negative_regulation denotes deficiency
T6693 1537-1544 Protein denotes SHARPIN
T6694 2015-2020 Protein denotes HMGB1
T6695 2021-2031 Binding denotes recognized
T6696 2035-2039 Protein denotes TLR2
T6697 2040-2041 Protein denotes 4
T6698 2548-2555 Protein denotes IL12P35
T6699 2561-2568 Protein denotes IL12P40
T6700 2569-2578 Negative_regulation denotes deficient
T6701 2569-2578 Negative_regulation denotes deficient
T6702 2664-2668 Protein denotes IRF3
T6703 2930-2940 Positive_regulation denotes activation
T6704 2930-2940 Positive_regulation denotes activation
T6705 2930-2940 Positive_regulation denotes activation
T6706 2930-2940 Positive_regulation denotes activation
T6707 2944-2948 Protein denotes TBK1
T6708 2949-2953 Protein denotes IRF3
T6709 2955-2959 Protein denotes ERK1
T6710 2960-2961 Protein denotes 2
T6711 2970-2977 Negative_regulation denotes was not true
T6712 2970-2977 Negative_regulation denotes was not true
T6713 2970-2977 Negative_regulation denotes was not true
T6714 2970-2977 Negative_regulation denotes was not true
T6715 3386-3393 Protein denotes SHARPIN
T6716 3548-3551 Protein denotes A20
T6717 3556-3560 Protein denotes ITCH
T6718 4151-4159 Negative_regulation denotes deletion
T6719 4163-4170 Protein denotes Sharpin
T6720 4228-4235 Protein denotes SHARPIN
T6721 4295-4302 Negative_regulation denotes absence
T6722 4306-4313 Protein denotes Sharpin
T6723 4314-4324 Gene_expression denotes expression
T6724 4666-4670 Protein denotes p100
T6725 4693-4696 Protein denotes p52
T6726 4722-4729 Protein denotes SHARPIN
T6727 4730-4739 Negative_regulation denotes deficient
T6728 4793-4796 Protein denotes p52
T6729 4797-4801 Protein denotes RELB
T6730 4917-4924 Protein denotes Sharpin
T6731 4925-4933 Negative_regulation denotes mutation
T6732 5070-5076 Binding denotes engage
T6733 5070-5076 Binding denotes engage
T6734 5077-5081 Protein denotes TLR4
T6735 5086-5090 Protein denotes TLR3
T6736 5302-5309 Binding denotes engages
T6737 5310-5314 Protein denotes TLR4
T6738 5327-5332 Protein denotes MYD88
T6739 5347-5351 Protein denotes TRIF
T6740 5380-5384 Protein denotes TLR3
T6741 5385-5395 Positive_regulation denotes stimulated
T6742 5422-5426 Protein denotes TRIF
T6743 5518-5525 Protein denotes Sharpin
T6744 5526-5534 Negative_regulation denotes mutation
T6745 5626-5630 Protein denotes RIP1
T6746 5635-5640 Protein denotes TRAF6
T6747 5680-5687 Protein denotes SHARPIN
T6748 5688-5697 Binding denotes interacts
T6749 5703-5707 Protein denotes HOIP
T6750 5727-5733 Positive_regulation denotes exerts
T6751 5727-5733 Positive_regulation denotes exerts
T6752 5738-5776 Ubiquitination denotes linear-ubiquitin-chain-ligase activity
T6753 5738-5776 Ubiquitination denotes linear-ubiquitin-chain-ligase activity
T6754 5804-5808 Protein denotes RIP1
T6755 5813-5817 Protein denotes NEMO
T6756 5852-5856 Protein denotes TNFα
T6757 5890-5897 Protein denotes Sharpin
T6758 5898-5911 Negative_regulation denotes null mutation
T6759 5912-5920 Negative_regulation denotes disrupts
T6760 5912-5920 Negative_regulation denotes disrupts
T6683 42-56 Negative_regulation denotes null mutations
T6761 5966-5970 Protein denotes TNFα
T6762 6134-6141 Protein denotes SHARPIN
T6763 6255-6262 Protein denotes SHARPIN
T6764 6384-6391 Protein denotes Sharpin
T6765 6392-6401 Negative_regulation denotes deficient
R5387 T6719 T6718 themeOf Sharpin,deletion
R5388 T6722 T6723 themeOf Sharpin,expression
R5389 T6723 T6721 themeOf expression,absence
R5390 T6726 T6727 themeOf SHARPIN,deficient
R5391 T6730 T6731 themeOf Sharpin,mutation
R5392 T6734 T6732 themeOf TLR4,engage
R5393 T6735 T6733 themeOf TLR3,engage
R5394 T6737 T6736 themeOf TLR4,engages
R5395 T6740 T6741 themeOf TLR3,stimulated
R5396 T6743 T6744 themeOf Sharpin,mutation
R5397 T6747 T6748 themeOf SHARPIN,interacts
R5398 T6747 T6752 causeOf SHARPIN,linear-ubiquitin-chain-ligase activity
R5399 T6747 T6753 causeOf SHARPIN,linear-ubiquitin-chain-ligase activity
R5400 T6749 T6748 themeOf HOIP,interacts
R5401 T6752 T6751 themeOf linear-ubiquitin-chain-ligase activity,exerts
R5402 T6752 T6759 themeOf linear-ubiquitin-chain-ligase activity,disrupts
R5403 T6753 T6750 themeOf linear-ubiquitin-chain-ligase activity,exerts
R5404 T6753 T6760 themeOf linear-ubiquitin-chain-ligase activity,disrupts
R5405 T6754 T6752 themeOf RIP1,linear-ubiquitin-chain-ligase activity
R5406 T6755 T6753 themeOf NEMO,linear-ubiquitin-chain-ligase activity
R5407 T6757 T6758 themeOf Sharpin,null mutation
R5408 T6758 T6759 causeOf null mutation,disrupts
R5409 T6758 T6760 causeOf null mutation,disrupts
R5410 T6764 T6765 themeOf Sharpin,deficient
R5370 T6684 T6683 themeOf Sharpin,null mutations
R5371 T6686 T6685 themeOf SHARPIN,loss
R5372 T6687 T6688 themeOf SHARPIN,disruption
R5373 T6691 T6690 themeOf TNF,deletion
R5374 T6693 T6692 themeOf SHARPIN,deficiency
R5375 T6694 T6695 themeOf HMGB1,recognized
R5376 T6696 T6695 themeOf TLR2,recognized
R5377 T6698 T6701 themeOf IL12P35,deficient
R5378 T6699 T6700 themeOf IL12P40,deficient
R5379 T6703 T6712 themeOf activation,was not
R5380 T6704 T6714 themeOf activation,was not
R5381 T6705 T6711 themeOf activation,was not
R5382 T6706 T6713 themeOf activation,was not
R5383 T6707 T6706 themeOf TBK1,activation
R5384 T6708 T6705 themeOf IRF3,activation
R5385 T6709 T6703 themeOf ERK1,activation
R5386 T6710 T6704 themeOf 2,activation

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T9043 70-77 Q9H0F6 denotes Sharpin
T9044 210-217 Q9H0F6 denotes SHARPIN
T9045 685-692 Q9H0F6 denotes SHARPIN
T9046 1493-1496 P01375 denotes TNF
T9047 1537-1544 Q9H0F6 denotes SHARPIN
T9048 2035-2039 O60603 denotes TLR2
T9049 2664-2668 Q14653 denotes IRF3
T9050 2944-2948 Q9UHD2 denotes TBK1
T9051 2949-2953 Q14653 denotes IRF3
T9052 2955-2959 P27361 denotes ERK1
T9053 2966-2969 Q16539 denotes p38
T9054 2966-2969 P53778 denotes p38
T9055 2966-2969 O15264 denotes p38
T9056 2966-2969 Q15759 denotes p38
T9057 3386-3393 Q9H0F6 denotes SHARPIN
T9058 3548-3551 P21580 denotes A20
T9059 4163-4170 Q9H0F6 denotes Sharpin
T9060 4228-4235 Q9H0F6 denotes SHARPIN
T9061 4306-4313 Q9H0F6 denotes Sharpin
T9062 4666-4670 Q00653 denotes p100
T9063 4693-4696 Q00653 denotes p52
T9064 4722-4729 Q9H0F6 denotes SHARPIN
T9065 4793-4796 Q00653 denotes p52
T9066 4797-4801 Q01201 denotes RELB
T9067 4917-4924 Q9H0F6 denotes Sharpin
T9068 5077-5081 O00206 denotes TLR4
T9069 5086-5090 O15455 denotes TLR3
T9070 5140-5144 O00206 denotes TLR4
T9071 5310-5314 O00206 denotes TLR4
T9072 5380-5384 O15455 denotes TLR3
T9073 5518-5525 Q9H0F6 denotes Sharpin
T9074 5626-5630 Q13546 denotes RIP1
T9075 5635-5640 Q9Y4K3 denotes TRAF6
T9076 5680-5687 Q9H0F6 denotes SHARPIN
T9077 5703-5707 Q96EP0 denotes HOIP
T9078 5804-5808 Q13546 denotes RIP1
T9079 5813-5817 Q9Y6K9 denotes NEMO
T9080 5890-5897 Q9H0F6 denotes Sharpin
T9081 6134-6141 Q9H0F6 denotes SHARPIN
T9082 6255-6262 Q9H0F6 denotes SHARPIN
T9083 6384-6391 Q9H0F6 denotes Sharpin