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PMC:3279418 / 1758-4724 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
22348129-11178875-89575657 119-120 11178875 denotes 1
22348129-17538631-89575658 185-186 17538631 denotes 2
22348129-17538631-89575659 492-493 17538631 denotes 2
22348129-17538631-89575660 684-685 17538631 denotes 2
22348129-10201907-89575661 688-689 10201907 denotes 4
22348129-11241277-89575662 1035-1036 11241277 denotes 5
22348129-11241277-89575663 1137-1138 11241277 denotes 5
22348129-11241277-89575664 1326-1327 11241277 denotes 5
22348129-19650867-89575665 1533-1534 19650867 denotes 6
22348129-21455173-89575666 1727-1728 21455173 denotes 7
22348129-21455180-89575667 1731-1732 21455180 denotes 9
22348129-21455173-89575668 1902-1903 21455173 denotes 7
22348129-21455180-89575669 1906-1907 21455180 denotes 9
22348129-20853490-89575670 2058-2060 20853490 denotes 10
T60732 119-120 11178875 denotes 1
T3640 185-186 17538631 denotes 2
T64062 492-493 17538631 denotes 2
T26028 684-685 17538631 denotes 2
T66489 688-689 10201907 denotes 4
T8236 1035-1036 11241277 denotes 5
T15760 1137-1138 11241277 denotes 5
T58148 1326-1327 11241277 denotes 5
T59353 1533-1534 19650867 denotes 6
T71923 1727-1728 21455173 denotes 7
T56508 1731-1732 21455180 denotes 9
T89522 1902-1903 21455173 denotes 7
T20207 1906-1907 21455180 denotes 9
T46751 2058-2060 20853490 denotes 10

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T1486 13-20 NN denotes SHARPIN
T1487 21-24 VB denotes was
T1488 25-35 RB denotes originally
T1489 36-46 VB denotes identified
T1490 47-49 IN denotes in
T1491 50-63 JJ denotes post-synaptic
T1492 64-73 NN denotes densities
T1493 74-76 IN denotes of
T1494 77-87 JJ denotes excitatory
T1495 88-96 NN denotes synapses
T1496 97-99 IN denotes in
T1497 100-103 DT denotes the
T1498 104-109 NN denotes brain
T1499 110-112 IN denotes of
T1500 113-117 NN denotes rats
T1501 118-119 -LRB- denotes [
T1502 119-120 CD denotes 1
T1503 120-121 -RRB- denotes ]
T1504 121-122 -COMMA- denotes ,
T1505 123-126 CC denotes but
T1506 127-131 DT denotes this
T1507 132-139 NN denotes protein
T1508 140-142 VB denotes is
T1509 143-149 RB denotes widely
T1510 150-159 VB denotes expressed
T1511 160-162 IN denotes in
T1512 163-164 DT denotes a
T1513 165-172 NN denotes variety
T1514 173-175 IN denotes of
T1515 176-183 NN denotes tissues
T1516 184-185 -LRB- denotes [
T1517 185-186 CD denotes 2
T1518 186-187 -RRB- denotes ]
T1519 189-192 CD denotes Two
T1520 193-200 JJ denotes allelic
T1521 200-201 -COMMA- denotes ,
T1522 202-211 JJ denotes autosomal
T1523 212-221 JJ denotes recessive
T1524 222-231 NN denotes mutations
T1525 232-234 IN denotes in
T1526 235-238 DT denotes the
T1527 239-246 NN denotes Sharpin
T1528 247-251 NN denotes gene
T1529 252-260 VB denotes occurred
T1530 261-274 RB denotes spontaneously
T1531 275-277 IN denotes in
T1532 278-281 CD denotes two
T1533 282-288 JJ denotes inbred
T1534 289-296 NN denotes strains
T1535 297-299 IN denotes of
T1536 300-304 NN denotes mice
T1537 304-305 -COMMA- denotes ,
T1538 306-343 NN denotes C57B/KaLawRij-Sharpincpdm/Sharpincpdm
T1539 344-347 CC denotes and
T1540 348-392 NN denotes CBy.Ocb3/Dem-Sharpincpdm-Dem/Sharpincpdm-Dem
T1541 392-393 -COMMA- denotes ,
T1542 394-403 VB denotes resulting
T1543 404-406 IN denotes in
T1544 407-416 JJ denotes premature
T1545 417-428 NN denotes termination
T1546 429-431 IN denotes of
T1547 432-436 NN denotes mRNA
T1548 437-446 NN denotes synthesis
T1549 447-450 CC denotes and
T1550 451-458 NN denotes absence
T1551 459-461 IN denotes of
T1552 462-463 DT denotes a
T1553 464-474 JJ denotes functional
T1554 475-482 NN denotes protein
T1555 483-490 NN denotes product
T1556 491-492 -LRB- denotes [
T1557 492-493 CD denotes 2
T1558 493-494 -RRB- denotes ]
T1559 496-503 IN denotes Despite
T1560 504-513 JJ denotes different
T1561 514-521 JJ denotes genetic
T1562 522-533 NN denotes backgrounds
T1563 533-534 -COMMA- denotes ,
T1564 535-539 DT denotes both
T1565 540-549 NN denotes mutations
T1566 550-555 VB denotes cause
T1567 556-563 JJ denotes similar
T1568 564-576 JJ denotes inflammatory
T1569 577-584 NN denotes disease
T1570 585-589 IN denotes with
T1571 590-596 JJ denotes severe
T1572 597-604 JJ denotes chronic
T1573 605-616 JJ denotes progressive
T1574 617-627 NN denotes dermatitis
T1575 628-631 CC denotes and
T1576 632-641 JJ denotes defective
T1577 642-653 NN denotes development
T1578 654-656 IN denotes of
T1579 657-666 JJ denotes secondary
T1580 667-675 JJ denotes lymphoid
T1581 676-682 NN denotes organs
T1582 683-684 -LRB- denotes [
T1583 684-685 CD denotes 2
T1584 685-686 -RRB- denotes ]
T1585 686-687 NN denotes –
T1586 687-688 -LRB- denotes [
T1587 688-689 CD denotes 4
T1588 689-690 -RRB- denotes ]
T1589 692-695 DT denotes The
T1590 696-706 NN denotes dermatitis
T1591 707-714 VB denotes becomes
T1592 715-725 RB denotes clinically
T1593 726-734 JJ denotes apparent
T1594 735-737 IN denotes at
T1595 738-743 RB denotes about
T1596 744-748 CD denotes four
T1597 749-754 NN denotes weeks
T1598 755-757 IN denotes of
T1599 758-761 NN denotes age
T1600 763-768 EX denotes There
T1601 769-772 VB denotes are
T1602 773-786 NN denotes accumulations
T1603 787-789 IN denotes of
T1604 790-801 NN denotes eosinophils
T1605 801-802 -COMMA- denotes ,
T1606 803-814 NN denotes neutrophils
T1607 815-818 CC denotes and
T1608 819-830 NN denotes macrophages
T1609 831-833 IN denotes in
T1610 834-837 DT denotes the
T1611 838-842 NN denotes skin
T1612 843-845 IN denotes of
T1613 846-869 NNP denotes Sharpincpdm/Sharpincpdm
T1614 870-876 JJ denotes mutant
T1615 877-881 NN denotes mice
T1616 882-883 -LRB- denotes (
T1617 883-892 RB denotes hereafter
T1618 893-901 VB denotes referred
T1619 902-904 TO denotes to
T1620 905-907 IN denotes as
T1621 908-912 NN denotes cpdm
T1622 913-917 NN denotes mice
T1623 917-918 -RRB- denotes )
T1624 919-929 VB denotes associated
T1625 930-934 IN denotes with
T1626 935-944 VB denotes increased
T1627 945-955 NN denotes expression
T1628 956-958 IN denotes of
T1629 959-962 NN denotes Th2
T1630 963-972 NN denotes cytokines
T1631 973-975 IN denotes in
T1632 976-979 DT denotes the
T1633 980-984 NN denotes skin
T1634 985-988 CC denotes and
T1635 989-991 IN denotes in
T1636 992-995 DT denotes the
T1637 996-1008 NN denotes supernatants
T1638 1009-1011 IN denotes of
T1639 1012-1021 VB denotes activated
T1640 1022-1033 NN denotes splenocytes
T1641 1034-1035 -LRB- denotes [
T1642 1035-1036 CD denotes 5
T1643 1036-1037 -RRB- denotes ]
T1644 1039-1042 DT denotes The
T1645 1043-1047 NN denotes mice
T1646 1048-1052 VB denotes have
T1647 1053-1055 DT denotes an
T1648 1056-1064 JJ denotes impaired
T1649 1065-1072 VB denotes delayed
T1650 1073-1077 NN denotes type
T1651 1078-1094 NN denotes hypersensitivity
T1652 1095-1103 NN denotes response
T1653 1104-1107 CC denotes and
T1654 1108-1117 VB denotes decreased
T1655 1118-1127 NN denotes secretion
T1656 1128-1130 IN denotes of
T1657 1131-1135 NN denotes IFNγ
T1658 1136-1137 -LRB- denotes [
T1659 1137-1138 CD denotes 5
T1660 1138-1139 -RRB- denotes ]
T1661 1139-1140 -COMMA- denotes ,
T1662 1141-1151 VB denotes indicating
T1663 1152-1153 DT denotes a
T1664 1154-1160 NN denotes defect
T1665 1161-1163 IN denotes in
T1666 1164-1167 NN denotes Th1
T1667 1168-1174 JJ denotes immune
T1668 1175-1184 NN denotes responses
T1669 1185-1188 CC denotes and
T1670 1189-1190 DT denotes a
T1671 1191-1195 NN denotes bias
T1672 1196-1203 IN denotes towards
T1673 1204-1205 DT denotes a
T1674 1206-1209 NN denotes Th2
T1675 1210-1216 JJ denotes immune
T1676 1217-1225 NN denotes response
T1677 1227-1235 JJ denotes Systemic
T1678 1236-1245 NN denotes treatment
T1679 1246-1248 IN denotes of
T1680 1249-1253 NN denotes cpdm
T1681 1254-1258 NN denotes mice
T1682 1259-1263 IN denotes with
T1683 1264-1275 JJ denotes recombinant
T1684 1276-1280 NN denotes IL12
T1685 1281-1287 VB denotes caused
T1686 1288-1296 JJ denotes complete
T1687 1297-1306 NN denotes remission
T1688 1307-1309 IN denotes of
T1689 1310-1313 DT denotes the
T1690 1314-1324 NN denotes dermatitis
T1691 1325-1326 -LRB- denotes [
T1692 1326-1327 CD denotes 5
T1693 1327-1328 -RRB- denotes ]
T1694 1330-1344 NN denotes Neutralization
T1695 1345-1347 IN denotes of
T1696 1348-1351 NN denotes IL5
T1697 1352-1354 IN denotes by
T1698 1355-1363 NN denotes antibody
T1699 1364-1373 NN denotes treatment
T1700 1374-1376 CC denotes or
T1701 1377-1384 NN denotes crosses
T1702 1385-1389 IN denotes with
T1703 1390-1403 JJ denotes IL5-deficient
T1704 1404-1408 NN denotes mice
T1705 1409-1416 VB denotes reduced
T1706 1417-1420 DT denotes the
T1707 1421-1427 NN denotes number
T1708 1428-1430 IN denotes of
T1709 1431-1442 VB denotes circulating
T1710 1443-1446 CC denotes and
T1711 1447-1456 JJ denotes cutaneous
T1712 1457-1468 NN denotes eosinophils
T1713 1468-1469 -COMMA- denotes ,
T1714 1470-1473 CC denotes but
T1715 1474-1480 VB denotes failed
T1716 1481-1483 TO denotes to
T1717 1484-1490 VB denotes reduce
T1718 1491-1494 DT denotes the
T1719 1495-1500 NN denotes onset
T1720 1501-1504 CC denotes and
T1721 1505-1513 NN denotes severity
T1722 1514-1516 IN denotes of
T1723 1517-1520 DT denotes the
T1724 1521-1531 NN denotes dermatitis
T1725 1532-1533 -LRB- denotes [
T1726 1533-1534 CD denotes 6
T1727 1534-1535 -RRB- denotes ]
T1728 1537-1545 RB denotes Recently
T1729 1545-1546 -COMMA- denotes ,
T1730 1547-1552 CD denotes three
T1731 1553-1564 JJ denotes independent
T1732 1565-1571 NN denotes groups
T1733 1572-1582 VB denotes identified
T1734 1583-1590 NN denotes SHARPIN
T1735 1591-1593 IN denotes as
T1736 1594-1596 DT denotes an
T1737 1597-1606 JJ denotes essential
T1738 1607-1616 NN denotes component
T1739 1617-1619 IN denotes of
T1740 1620-1623 DT denotes the
T1741 1624-1630 JJ denotes linear
T1742 1631-1640 NN denotes ubiquitin
T1743 1641-1646 NN denotes chain
T1744 1647-1655 NN denotes assembly
T1745 1656-1663 NN denotes complex
T1746 1664-1665 -LRB- denotes (
T1747 1665-1670 NN denotes LUBAC
T1748 1670-1671 -RRB- denotes )
T1749 1672-1676 WDT denotes that
T1750 1677-1686 VB denotes regulates
T1751 1687-1699 JJ denotes TNFα-induced
T1752 1700-1709 JJ denotes canonical
T1753 1710-1715 NN denotes NF-κB
T1754 1716-1725 NN denotes signaling
T1755 1726-1727 -LRB- denotes [
T1756 1727-1728 CD denotes 7
T1757 1728-1729 -RRB- denotes ]
T1758 1729-1730 NN denotes –
T1759 1730-1731 -LRB- denotes [
T1760 1731-1732 CD denotes 9
T1761 1732-1733 -RRB- denotes ]
T1762 1735-1752 JJ denotes SHARPIN-deficient
T1763 1753-1758 NN denotes mouse
T1764 1759-1768 JJ denotes embryonic
T1765 1769-1779 NN denotes fibroblast
T1766 1780-1781 -LRB- denotes (
T1767 1781-1784 NN denotes MEF
T1768 1784-1785 -RRB- denotes )
T1769 1786-1790 VB denotes were
T1770 1791-1801 VB denotes sensitized
T1771 1802-1804 TO denotes to
T1772 1805-1817 JJ denotes TNFα-induced
T1773 1818-1827 NN denotes apoptosis
T1774 1828-1831 CC denotes and
T1775 1832-1836 NN denotes cell
T1776 1837-1842 NN denotes death
T1777 1843-1846 VB denotes was
T1778 1847-1857 VB denotes implicated
T1779 1858-1860 IN denotes as
T1780 1861-1862 DT denotes a
T1781 1863-1869 NN denotes factor
T1782 1870-1872 IN denotes in
T1783 1873-1876 DT denotes the
T1784 1877-1887 NN denotes dermatitis
T1785 1888-1890 IN denotes of
T1786 1891-1895 NN denotes cpdm
T1787 1896-1900 NN denotes mice
T1788 1901-1902 -LRB- denotes [
T1789 1902-1903 CD denotes 7
T1790 1903-1904 -RRB- denotes ]
T1791 1904-1905 NN denotes –
T1792 1905-1906 -LRB- denotes [
T1793 1906-1907 CD denotes 9
T1794 1907-1908 -RRB- denotes ]
T1795 1910-1919 JJ denotes Dendritic
T1796 1920-1925 NN denotes cells
T1797 1926-1927 -LRB- denotes (
T1798 1927-1929 NN denotes DC
T1799 1929-1930 -RRB- denotes )
T1800 1931-1935 VB denotes have
T1801 1936-1937 DT denotes a
T1802 1938-1946 NN denotes sentinel
T1803 1947-1951 NN denotes role
T1804 1952-1954 IN denotes in
T1805 1955-1962 VB denotes sensing
T1806 1963-1971 NN denotes pathogen
T1807 1972-1974 CC denotes or
T1808 1975-1981 NN denotes danger
T1809 1982-1989 NN denotes signals
T1810 1990-1993 CC denotes and
T1811 1994-2002 NN denotes initiate
T1812 2003-2006 CC denotes and
T1813 2007-2013 JJ denotes direct
T1814 2014-2024 NN denotes activation
T1815 2025-2027 IN denotes of
T1816 2028-2031 DT denotes the
T1817 2032-2040 JJ denotes adaptive
T1818 2041-2047 JJ denotes immune
T1819 2048-2056 NN denotes response
T1820 2057-2058 -LRB- denotes [
T1821 2058-2060 CD denotes 10
T1822 2060-2061 -RRB- denotes ]
T1823 2063-2072 VB denotes Activated
T1824 2073-2076 CC denotes and
T1825 2077-2083 JJ denotes mature
T1826 2084-2086 NN denotes DC
T1827 2087-2090 MD denotes can
T1828 2091-2096 VB denotes carry
T1829 2097-2106 VB denotes processed
T1830 2107-2116 JJ denotes antigenic
T1831 2117-2125 NN denotes peptides
T1832 2125-2126 -COMMA- denotes ,
T1833 2127-2134 VB denotes migrate
T1834 2135-2137 TO denotes to
T1835 2138-2146 JJ denotes lymphoid
T1836 2147-2153 NN denotes organs
T1837 2153-2154 -COMMA- denotes ,
T1838 2155-2158 CC denotes and
T1839 2159-2165 VB denotes induce
T1840 2166-2181 JJ denotes T-cell-mediated
T1841 2182-2188 JJ denotes immune
T1842 2189-2198 NN denotes responses
T1843 2199-2201 CC denotes or
T1844 2202-2211 NN denotes tolerance
T1845 2213-2215 NN denotes DC
T1846 2216-2222 VB denotes direct
T1847 2223-2226 DT denotes the
T1848 2227-2242 NN denotes differentiation
T1849 2243-2245 IN denotes of
T1850 2246-2250 JJ denotes CD4+
T1851 2251-2252 NN denotes T
T1852 2253-2258 NN denotes cells
T1853 2258-2259 -COMMA- denotes ,
T1854 2260-2263 CC denotes and
T1855 2264-2269 RB denotes hence
T1856 2270-2273 DT denotes the
T1857 2274-2278 NN denotes type
T1858 2279-2281 IN denotes of
T1859 2282-2288 JJ denotes immune
T1860 2289-2297 NN denotes response
T1861 2297-2298 -COMMA- denotes ,
T1862 2299-2306 IN denotes through
T1863 2307-2310 DT denotes the
T1864 2311-2320 JJ denotes selective
T1865 2321-2330 NN denotes secretion
T1866 2331-2333 IN denotes of
T1867 2334-2343 NN denotes cytokines
T1868 2345-2347 PRP denotes We
T1869 2348-2360 VB denotes hypothesized
T1870 2361-2365 IN denotes that
T1871 2366-2375 JJ denotes defective
T1872 2376-2384 NN denotes cytokine
T1873 2385-2394 NN denotes secretion
T1874 2395-2397 IN denotes by
T1875 2398-2400 NN denotes DC
T1876 2401-2412 VB denotes contributed
T1877 2413-2415 TO denotes to
T1878 2416-2419 DT denotes the
T1879 2420-2430 JJ denotes Th2-biased
T1880 2431-2443 JJ denotes inflammatory
T1881 2444-2453 NN denotes phenotype
T1882 2454-2456 IN denotes in
T1883 2457-2474 JJ denotes SHARPIN-deficient
T1884 2475-2479 NN denotes mice
T1885 2481-2484 DT denotes The
T1886 2485-2492 NN denotes studies
T1887 2493-2501 VB denotes reported
T1888 2502-2506 RB denotes here
T1889 2507-2512 VB denotes found
T1890 2513-2517 IN denotes that
T1891 2518-2522 NN denotes lack
T1892 2523-2525 IN denotes of
T1893 2526-2533 NN denotes SHARPIN
T1894 2534-2541 NN denotes protein
T1895 2542-2544 IN denotes in
T1896 2545-2549 NN denotes BMDC
T1897 2550-2556 VB denotes caused
T1898 2557-2566 JJ denotes defective
T1899 2567-2577 NN denotes expression
T1900 2578-2580 IN denotes of
T1901 2581-2597 JJ denotes pro-inflammatory
T1902 2598-2607 NN denotes mediators
T1903 2608-2611 CC denotes and
T1904 2612-2620 JJ denotes impaired
T1905 2621-2626 NN denotes NF-κB
T1906 2627-2637 NN denotes activation
T1907 2638-2642 IN denotes upon
T1908 2643-2649 NN denotes ligand
T1909 2650-2661 NN denotes stimulation
T1910 2663-2666 DT denotes The
T1911 2667-2674 NN denotes ability
T1912 2675-2677 IN denotes of
T1913 2678-2682 NN denotes cpdm
T1914 2683-2687 NN denotes BMDC
T1915 2688-2690 TO denotes to
T1916 2691-2700 VB denotes stimulate
T1917 2701-2704 NN denotes Th1
T1918 2705-2713 NN denotes cytokine
T1919 2714-2724 NN denotes production
T1920 2725-2727 IN denotes in
T1921 2728-2738 JJ denotes allogeneic
T1922 2739-2743 JJ denotes CD4+
T1923 2744-2745 NN denotes T
T1924 2746-2751 NN denotes cells
T1925 2752-2755 VB denotes was
T1926 2756-2767 VB denotes compromised
T1927 2769-2774 VB denotes Taken
T1928 2775-2783 RB denotes together
T1929 2783-2784 -COMMA- denotes ,
T1930 2785-2790 DT denotes these
T1931 2791-2798 NN denotes results
T1932 2799-2805 VB denotes reveal
T1933 2806-2810 IN denotes that
T1934 2811-2818 NN denotes SHARPIN
T1935 2819-2821 VB denotes is
T1936 2822-2823 DT denotes a
T1937 2824-2829 JJ denotes novel
T1938 2830-2840 JJ denotes regulatory
T1939 2841-2849 NN denotes molecule
T1940 2850-2852 IN denotes in
T1941 2853-2855 NN denotes DC
T1942 2856-2863 NN denotes biology
T1943 2864-2867 CC denotes and
T1944 2868-2875 VB denotes suggest
T1945 2876-2880 IN denotes that
T1946 2881-2884 DT denotes the
T1947 2885-2897 VB denotes dysregulated
T1948 2898-2906 NN denotes function
T1949 2907-2909 IN denotes of
T1950 2910-2927 JJ denotes SHARPIN-deficient
T1951 2928-2930 NN denotes DC
T1952 2931-2936 VB denotes plays
T1953 2937-2938 DT denotes a
T1954 2939-2943 NN denotes role
T1955 2944-2946 IN denotes in
T1956 2947-2950 DT denotes the
T1957 2951-2955 NN denotes cpdm
T1958 2956-2965 NN denotes phenotype
R1248 T1486 T1487 arg1Of SHARPIN,was
R1249 T1486 T1489 arg2Of SHARPIN,identified
R1250 T1489 T1487 arg2Of identified,was
R1251 T1489 T1488 arg1Of identified,originally
R1252 T1489 T1490 arg1Of identified,in
R1253 T1489 T1505 arg1Of identified,but
R1254 T1492 T1490 arg2Of densities,in
R1255 T1492 T1491 arg1Of densities,post-synaptic
R1256 T1492 T1493 arg1Of densities,of
R1257 T1495 T1493 arg2Of synapses,of
R1258 T1495 T1494 arg1Of synapses,excitatory
R1259 T1495 T1496 arg1Of synapses,in
R1260 T1498 T1496 arg2Of brain,in
R1261 T1498 T1497 arg1Of brain,the
R1262 T1498 T1499 arg1Of brain,of
R1263 T1500 T1499 arg2Of rats,of
R1264 T1500 T1501 arg1Of rats,[
R1265 T1502 T1501 arg2Of 1,[
R1266 T1503 T1501 arg3Of ],[
R1267 T1505 T1504 arg1Of but,","
R1268 T1507 T1506 arg1Of protein,this
R1269 T1507 T1508 arg1Of protein,is
R1270 T1507 T1510 arg2Of protein,expressed
R1271 T1510 T1505 arg2Of expressed,but
R1272 T1510 T1508 arg2Of expressed,is
R1273 T1510 T1509 arg1Of expressed,widely
R1274 T1510 T1511 arg1Of expressed,in
R1275 T1513 T1511 arg2Of variety,in
R1276 T1513 T1512 arg1Of variety,a
R1277 T1513 T1514 arg1Of variety,of
R1278 T1515 T1514 arg2Of tissues,of
R1279 T1515 T1516 arg1Of tissues,[
R1280 T1517 T1516 arg2Of 2,[
R1281 T1518 T1516 arg3Of ],[
R1282 T1520 T1521 arg1Of allelic,","
R1283 T1522 T1521 arg2Of autosomal,","
R1284 T1524 T1519 arg1Of mutations,Two
R1285 T1524 T1520 arg1Of mutations,allelic
R1286 T1524 T1522 arg1Of mutations,autosomal
R1287 T1524 T1523 arg1Of mutations,recessive
R1288 T1524 T1525 arg1Of mutations,in
R1289 T1524 T1529 arg1Of mutations,occurred
R1290 T1528 T1525 arg2Of gene,in
R1291 T1528 T1526 arg1Of gene,the
R1292 T1528 T1527 arg1Of gene,Sharpin
R1293 T1529 T1530 arg1Of occurred,spontaneously
R1294 T1529 T1531 arg1Of occurred,in
R1295 T1529 T1541 arg1Of occurred,","
R1296 T1529 T1542 modOf occurred,resulting
R1297 T1529 T1556 arg1Of occurred,[
R1298 T1534 T1531 arg2Of strains,in
R1299 T1534 T1532 arg1Of strains,two
R1300 T1534 T1533 arg1Of strains,inbred
R1301 T1534 T1535 arg1Of strains,of
R1302 T1534 T1537 arg1Of strains,","
R1303 T1536 T1535 arg2Of mice,of
R1304 T1538 T1539 arg1Of C57B/KaLawRij-Sharpincpdm/Sharpincpdm,and
R1305 T1539 T1537 arg2Of and,","
R1306 T1540 T1539 arg2Of CBy.Ocb3/Dem-Sharpincpdm-Dem/Sharpincpdm-Dem,and
R1307 T1542 T1543 arg1Of resulting,in
R1308 T1545 T1544 arg1Of termination,premature
R1309 T1545 T1546 arg1Of termination,of
R1310 T1545 T1549 arg1Of termination,and
R1311 T1548 T1546 arg2Of synthesis,of
R1312 T1548 T1547 arg1Of synthesis,mRNA
R1313 T1549 T1543 arg2Of and,in
R1314 T1550 T1549 arg2Of absence,and
R1315 T1550 T1551 arg1Of absence,of
R1316 T1555 T1551 arg2Of product,of
R1317 T1555 T1552 arg1Of product,a
R1318 T1555 T1553 arg1Of product,functional
R1319 T1555 T1554 arg1Of product,protein
R1320 T1557 T1556 arg2Of 2,[
R1321 T1558 T1556 arg3Of ],[
R1322 T1562 T1559 arg2Of backgrounds,Despite
R1323 T1562 T1560 arg1Of backgrounds,different
R1324 T1562 T1561 arg1Of backgrounds,genetic
R1325 T1565 T1564 arg1Of mutations,both
R1326 T1565 T1566 arg1Of mutations,cause
R1327 T1566 T1559 arg1Of cause,Despite
R1328 T1566 T1563 arg1Of cause,","
R1329 T1566 T1586 arg1Of cause,[
R1330 T1569 T1566 arg2Of disease,cause
R1331 T1569 T1567 arg1Of disease,similar
R1332 T1569 T1568 arg1Of disease,inflammatory
R1333 T1569 T1570 arg1Of disease,with
R1334 T1573 T1574 arg1Of progressive,dermatitis
R1335 T1573 T1575 arg1Of progressive,and
R1336 T1576 T1575 arg2Of defective,and
R1337 T1577 T1570 arg2Of development,with
R1338 T1577 T1571 arg1Of development,severe
R1339 T1577 T1572 arg1Of development,chronic
R1340 T1577 T1573 arg1Of development,progressive
R1341 T1577 T1576 arg1Of development,defective
R1342 T1577 T1578 arg1Of development,of
R1343 T1577 T1585 arg1Of development,–
R1344 T1581 T1578 arg2Of organs,of
R1345 T1581 T1579 arg1Of organs,secondary
R1346 T1581 T1580 arg1Of organs,lymphoid
R1347 T1581 T1582 arg1Of organs,[
R1348 T1583 T1582 arg2Of 2,[
R1349 T1584 T1582 arg3Of ],[
R1350 T1587 T1586 arg2Of 4,[
R1351 T1588 T1586 arg3Of ],[
R1352 T1590 T1589 arg1Of dermatitis,The
R1353 T1590 T1591 arg1Of dermatitis,becomes
R1354 T1590 T1593 arg1Of dermatitis,apparent
R1355 T1591 T1594 arg1Of becomes,at
R1356 T1593 T1591 arg2Of apparent,becomes
R1357 T1593 T1592 arg1Of apparent,clinically
R1358 T1596 T1595 arg1Of four,about
R1359 T1597 T1594 arg2Of weeks,at
R1360 T1597 T1596 arg1Of weeks,four
R1361 T1597 T1598 arg1Of weeks,of
R1362 T1599 T1598 arg2Of age,of
R1363 T1600 T1601 arg1Of There,are
R1364 T1602 T1601 arg2Of accumulations,are
R1365 T1602 T1603 arg1Of accumulations,of
R1366 T1602 T1616 arg1Of accumulations,(
R1367 T1602 T1624 arg2Of accumulations,associated
R1368 T1604 T1605 arg1Of eosinophils,","
R1369 T1605 T1607 arg1Of ",",and
R1370 T1606 T1605 arg2Of neutrophils,","
R1371 T1607 T1603 arg2Of and,of
R1372 T1607 T1609 arg1Of and,in
R1373 T1608 T1607 arg2Of macrophages,and
R1374 T1611 T1609 arg2Of skin,in
R1375 T1611 T1610 arg1Of skin,the
R1376 T1611 T1612 arg1Of skin,of
R1377 T1615 T1612 arg2Of mice,of
R1378 T1615 T1613 arg1Of mice,Sharpincpdm/Sharpincpdm
R1379 T1615 T1614 arg1Of mice,mutant
R1380 T1618 T1616 arg2Of referred,(
R1381 T1618 T1617 arg1Of referred,hereafter
R1382 T1618 T1619 arg1Of referred,to
R1383 T1618 T1620 arg1Of referred,as
R1384 T1622 T1620 arg2Of mice,as
R1385 T1622 T1621 arg1Of mice,cpdm
R1386 T1623 T1616 arg3Of ),(
R1387 T1624 T1625 arg1Of associated,with
R1388 T1624 T1635 arg1Of associated,in
R1389 T1625 T1634 arg1Of with,and
R1390 T1627 T1625 arg2Of expression,with
R1391 T1627 T1626 arg2Of expression,increased
R1392 T1627 T1628 arg1Of expression,of
R1393 T1627 T1631 arg1Of expression,in
R1394 T1630 T1628 arg2Of cytokines,of
R1395 T1630 T1629 arg1Of cytokines,Th2
R1396 T1633 T1631 arg2Of skin,in
R1397 T1633 T1632 arg1Of skin,the
R1398 T1635 T1634 arg2Of in,and
R1399 T1637 T1635 arg2Of supernatants,in
R1400 T1637 T1636 arg1Of supernatants,the
R1401 T1637 T1638 arg1Of supernatants,of
R1402 T1640 T1638 arg2Of splenocytes,of
R1403 T1640 T1639 arg2Of splenocytes,activated
R1404 T1640 T1641 arg1Of splenocytes,[
R1405 T1642 T1641 arg2Of 5,[
R1406 T1643 T1641 arg3Of ],[
R1407 T1645 T1644 arg1Of mice,The
R1408 T1645 T1646 arg1Of mice,have
R1409 T1645 T1654 arg1Of mice,decreased
R1410 T1646 T1653 arg1Of have,and
R1411 T1652 T1646 arg2Of response,have
R1412 T1652 T1647 arg1Of response,an
R1413 T1652 T1648 arg1Of response,impaired
R1414 T1652 T1649 arg2Of response,delayed
R1415 T1652 T1650 arg1Of response,type
R1416 T1652 T1651 arg1Of response,hypersensitivity
R1417 T1653 T1658 arg1Of and,[
R1418 T1653 T1661 arg1Of and,","
R1419 T1653 T1662 modOf and,indicating
R1420 T1654 T1653 arg2Of decreased,and
R1421 T1655 T1654 arg2Of secretion,decreased
R1422 T1655 T1656 arg1Of secretion,of
R1423 T1657 T1656 arg2Of IFNγ,of
R1424 T1659 T1658 arg2Of 5,[
R1425 T1660 T1658 arg3Of ],[
R1426 T1664 T1663 arg1Of defect,a
R1427 T1664 T1665 arg1Of defect,in
R1428 T1664 T1669 arg1Of defect,and
R1429 T1668 T1665 arg2Of responses,in
R1430 T1668 T1666 arg1Of responses,Th1
R1431 T1668 T1667 arg1Of responses,immune
R1432 T1669 T1662 arg2Of and,indicating
R1433 T1671 T1669 arg2Of bias,and
R1434 T1671 T1670 arg1Of bias,a
R1435 T1671 T1672 arg1Of bias,towards
R1436 T1676 T1672 arg2Of response,towards
R1437 T1676 T1673 arg1Of response,a
R1438 T1676 T1674 arg1Of response,Th2
R1439 T1676 T1675 arg1Of response,immune
R1440 T1678 T1677 arg1Of treatment,Systemic
R1441 T1678 T1679 arg1Of treatment,of
R1442 T1678 T1682 arg1Of treatment,with
R1443 T1678 T1685 arg1Of treatment,caused
R1444 T1681 T1679 arg2Of mice,of
R1445 T1681 T1680 arg1Of mice,cpdm
R1446 T1684 T1682 arg2Of IL12,with
R1447 T1684 T1683 arg1Of IL12,recombinant
R1448 T1685 T1691 arg1Of caused,[
R1449 T1687 T1685 arg2Of remission,caused
R1450 T1687 T1686 arg1Of remission,complete
R1451 T1687 T1688 arg1Of remission,of
R1452 T1690 T1688 arg2Of dermatitis,of
R1453 T1690 T1689 arg1Of dermatitis,the
R1454 T1692 T1691 arg2Of 5,[
R1455 T1693 T1691 arg3Of ],[
R1456 T1694 T1695 arg1Of Neutralization,of
R1457 T1694 T1697 arg1Of Neutralization,by
R1458 T1694 T1705 arg1Of Neutralization,reduced
R1459 T1694 T1715 arg1Of Neutralization,failed
R1460 T1694 T1717 arg1Of Neutralization,reduce
R1461 T1696 T1695 arg2Of IL5,of
R1462 T1699 T1698 arg1Of treatment,antibody
R1463 T1699 T1700 arg1Of treatment,or
R1464 T1700 T1697 arg2Of or,by
R1465 T1701 T1700 arg2Of crosses,or
R1466 T1701 T1702 arg1Of crosses,with
R1467 T1704 T1702 arg2Of mice,with
R1468 T1704 T1703 arg1Of mice,IL5-deficient
R1469 T1705 T1714 arg1Of reduced,but
R1470 T1707 T1705 arg2Of number,reduced
R1471 T1707 T1706 arg1Of number,the
R1472 T1707 T1708 arg1Of number,of
R1473 T1712 T1708 arg2Of eosinophils,of
R1474 T1712 T1709 arg1Of eosinophils,circulating
R1475 T1712 T1710 arg1Of eosinophils,and
R1476 T1712 T1711 arg1Of eosinophils,cutaneous
R1477 T1714 T1713 arg1Of but,","
R1478 T1715 T1714 arg2Of failed,but
R1479 T1717 T1715 arg2Of reduce,failed
R1480 T1717 T1716 arg1Of reduce,to
R1481 T1717 T1725 arg1Of reduce,[
R1482 T1719 T1720 arg1Of onset,and
R1483 T1720 T1717 arg2Of and,reduce
R1484 T1720 T1718 arg1Of and,the
R1485 T1720 T1722 arg1Of and,of
R1486 T1721 T1720 arg2Of severity,and
R1487 T1724 T1722 arg2Of dermatitis,of
R1488 T1724 T1723 arg1Of dermatitis,the
R1489 T1726 T1725 arg2Of 6,[
R1490 T1727 T1725 arg3Of ],[
R1491 T1732 T1730 arg1Of groups,three
R1492 T1732 T1731 arg1Of groups,independent
R1493 T1732 T1733 arg1Of groups,identified
R1494 T1733 T1728 arg1Of identified,Recently
R1495 T1733 T1729 arg1Of identified,","
R1496 T1733 T1735 arg1Of identified,as
R1497 T1734 T1733 arg2Of SHARPIN,identified
R1498 T1738 T1735 arg2Of component,as
R1499 T1738 T1736 arg1Of component,an
R1500 T1738 T1737 arg1Of component,essential
R1501 T1738 T1739 arg1Of component,of
R1502 T1745 T1739 arg2Of complex,of
R1503 T1745 T1740 arg1Of complex,the
R1504 T1745 T1741 arg1Of complex,linear
R1505 T1745 T1742 arg1Of complex,ubiquitin
R1506 T1745 T1743 arg1Of complex,chain
R1507 T1745 T1744 arg1Of complex,assembly
R1508 T1745 T1746 arg1Of complex,(
R1509 T1745 T1749 arg1Of complex,that
R1510 T1745 T1750 arg1Of complex,regulates
R1511 T1747 T1746 arg2Of LUBAC,(
R1512 T1748 T1746 arg3Of ),(
R1513 T1756 T1755 arg2Of 7,[
R1514 T1757 T1755 arg3Of ],[
R1515 T1758 T1750 arg2Of –,regulates
R1516 T1758 T1751 arg1Of –,TNFα-induced
R1517 T1758 T1752 arg1Of –,canonical
R1518 T1758 T1753 arg1Of –,NF-κB
R1519 T1758 T1754 arg1Of –,signaling
R1520 T1758 T1755 arg1Of –,[
R1521 T1758 T1759 arg1Of –,[
R1522 T1760 T1759 arg2Of 9,[
R1523 T1761 T1759 arg3Of ],[
R1524 T1765 T1762 arg1Of fibroblast,SHARPIN-deficient
R1525 T1765 T1763 arg1Of fibroblast,mouse
R1526 T1765 T1764 arg1Of fibroblast,embryonic
R1527 T1765 T1766 arg1Of fibroblast,(
R1528 T1765 T1769 arg1Of fibroblast,were
R1529 T1765 T1770 arg2Of fibroblast,sensitized
R1530 T1767 T1766 arg2Of MEF,(
R1531 T1768 T1766 arg3Of ),(
R1532 T1770 T1769 arg2Of sensitized,were
R1533 T1770 T1771 arg1Of sensitized,to
R1534 T1770 T1774 arg1Of sensitized,and
R1535 T1773 T1771 arg2Of apoptosis,to
R1536 T1773 T1772 arg1Of apoptosis,TNFα-induced
R1537 T1776 T1775 arg1Of death,cell
R1538 T1776 T1777 arg1Of death,was
R1539 T1776 T1778 arg2Of death,implicated
R1540 T1778 T1774 arg2Of implicated,and
R1541 T1778 T1777 arg2Of implicated,was
R1542 T1778 T1779 arg1Of implicated,as
R1543 T1778 T1792 arg1Of implicated,[
R1544 T1781 T1779 arg2Of factor,as
R1545 T1781 T1780 arg1Of factor,a
R1546 T1781 T1782 arg1Of factor,in
R1547 T1784 T1783 arg1Of dermatitis,the
R1548 T1784 T1785 arg1Of dermatitis,of
R1549 T1784 T1788 arg1Of dermatitis,[
R1550 T1787 T1785 arg2Of mice,of
R1551 T1787 T1786 arg1Of mice,cpdm
R1552 T1789 T1788 arg2Of 7,[
R1553 T1790 T1788 arg3Of ],[
R1554 T1791 T1782 arg2Of –,in
R1555 T1791 T1784 arg1Of –,dermatitis
R1556 T1793 T1792 arg2Of 9,[
R1557 T1794 T1792 arg3Of ],[
R1558 T1796 T1795 arg1Of cells,Dendritic
R1559 T1796 T1797 arg1Of cells,(
R1560 T1796 T1800 arg1Of cells,have
R1561 T1798 T1797 arg2Of DC,(
R1562 T1799 T1797 arg3Of ),(
R1563 T1800 T1804 arg1Of have,in
R1564 T1803 T1800 arg2Of role,have
R1565 T1803 T1801 arg1Of role,a
R1566 T1803 T1802 arg1Of role,sentinel
R1567 T1805 T1804 arg2Of sensing,in
R1568 T1806 T1807 arg1Of pathogen,or
R1569 T1808 T1807 arg2Of danger,or
R1570 T1809 T1810 arg1Of signals,and
R1571 T1810 T1806 arg1Of and,pathogen
R1572 T1810 T1808 arg1Of and,danger
R1573 T1810 T1812 arg1Of and,and
R1574 T1811 T1810 arg2Of initiate,and
R1575 T1812 T1805 arg2Of and,sensing
R1576 T1814 T1812 arg2Of activation,and
R1577 T1814 T1813 arg1Of activation,direct
R1578 T1814 T1815 arg1Of activation,of
R1579 T1819 T1815 arg2Of response,of
R1580 T1819 T1816 arg1Of response,the
R1581 T1819 T1817 arg1Of response,adaptive
R1582 T1819 T1818 arg1Of response,immune
R1583 T1819 T1820 arg1Of response,[
R1584 T1821 T1820 arg2Of 10,[
R1585 T1822 T1820 arg3Of ],[
R1586 T1823 T1824 arg1Of Activated,and
R1587 T1825 T1824 arg2Of mature,and
R1588 T1826 T1823 arg1Of DC,Activated
R1589 T1826 T1825 arg1Of DC,mature
R1590 T1826 T1827 arg1Of DC,can
R1591 T1826 T1828 arg1Of DC,carry
R1592 T1826 T1833 arg1Of DC,migrate
R1593 T1826 T1839 arg1Of DC,induce
R1594 T1828 T1827 arg2Of carry,can
R1595 T1828 T1832 arg1Of carry,","
R1596 T1831 T1828 arg2Of peptides,carry
R1597 T1831 T1829 arg2Of peptides,processed
R1598 T1831 T1830 arg1Of peptides,antigenic
R1599 T1832 T1838 arg1Of ",",and
R1600 T1833 T1832 arg2Of migrate,","
R1601 T1833 T1834 arg1Of migrate,to
R1602 T1836 T1834 arg2Of organs,to
R1603 T1836 T1835 arg1Of organs,lymphoid
R1604 T1838 T1837 arg1Of and,","
R1605 T1839 T1838 arg2Of induce,and
R1606 T1842 T1840 arg1Of responses,T-cell-mediated
R1607 T1842 T1841 arg1Of responses,immune
R1608 T1842 T1843 arg1Of responses,or
R1609 T1843 T1839 arg2Of or,induce
R1610 T1844 T1843 arg2Of tolerance,or
R1611 T1845 T1846 arg1Of DC,direct
R1612 T1846 T1861 arg1Of direct,","
R1613 T1846 T1862 arg1Of direct,through
R1614 T1848 T1847 arg1Of differentiation,the
R1615 T1848 T1849 arg1Of differentiation,of
R1616 T1848 T1854 arg1Of differentiation,and
R1617 T1852 T1849 arg2Of cells,of
R1618 T1852 T1850 arg1Of cells,CD4+
R1619 T1852 T1851 arg1Of cells,T
R1620 T1854 T1846 arg2Of and,direct
R1621 T1854 T1853 arg1Of and,","
R1622 T1857 T1854 arg2Of type,and
R1623 T1857 T1855 arg1Of type,hence
R1624 T1857 T1856 arg1Of type,the
R1625 T1857 T1858 arg1Of type,of
R1626 T1860 T1858 arg2Of response,of
R1627 T1860 T1859 arg1Of response,immune
R1628 T1865 T1862 arg2Of secretion,through
R1629 T1865 T1863 arg1Of secretion,the
R1630 T1865 T1864 arg1Of secretion,selective
R1631 T1865 T1866 arg1Of secretion,of
R1632 T1867 T1866 arg2Of cytokines,of
R1633 T1868 T1869 arg1Of We,hypothesized
R1634 T1873 T1871 arg1Of secretion,defective
R1635 T1873 T1872 arg1Of secretion,cytokine
R1636 T1873 T1874 arg1Of secretion,by
R1637 T1873 T1876 arg1Of secretion,contributed
R1638 T1875 T1874 arg2Of DC,by
R1639 T1876 T1869 arg2Of contributed,hypothesized
R1640 T1876 T1870 arg1Of contributed,that
R1641 T1902 T1900 arg2Of mediators,of
R1642 T1902 T1901 arg1Of mediators,pro-inflammatory
R1643 T1876 T1877 arg1Of contributed,to
R1644 T1903 T1897 arg2Of and,caused
R1645 T1881 T1877 arg2Of phenotype,to
R1646 T1906 T1903 arg2Of activation,and
R1647 T1906 T1904 arg1Of activation,impaired
R1648 T1906 T1905 arg1Of activation,NF-κB
R1649 T1906 T1907 arg1Of activation,upon
R1650 T1881 T1878 arg1Of phenotype,the
R1651 T1881 T1879 arg1Of phenotype,Th2-biased
R1652 T1881 T1880 arg1Of phenotype,inflammatory
R1653 T1909 T1907 arg2Of stimulation,upon
R1654 T1909 T1908 arg1Of stimulation,ligand
R1655 T1881 T1882 arg1Of phenotype,in
R1656 T1884 T1882 arg2Of mice,in
R1657 T1911 T1910 arg1Of ability,The
R1658 T1911 T1912 arg1Of ability,of
R1659 T1911 T1915 modOf ability,to
R1660 T1911 T1925 arg1Of ability,was
R1661 T1911 T1926 arg2Of ability,compromised
R1662 T1914 T1912 arg2Of BMDC,of
R1663 T1914 T1913 arg1Of BMDC,cpdm
R1664 T1916 T1915 arg1Of stimulate,to
R1665 T1884 T1883 arg1Of mice,SHARPIN-deficient
R1666 T1886 T1885 arg1Of studies,The
R1667 T1919 T1916 arg2Of production,stimulate
R1668 T1919 T1917 arg1Of production,Th1
R1669 T1919 T1918 arg1Of production,cytokine
R1670 T1919 T1920 arg1Of production,in
R1671 T1886 T1887 arg2Of studies,reported
R1672 T1886 T1889 arg1Of studies,found
R1673 T1887 T1888 arg1Of reported,here
R1674 T1924 T1920 arg2Of cells,in
R1675 T1924 T1921 arg1Of cells,allogeneic
R1676 T1924 T1922 arg1Of cells,CD4+
R1677 T1924 T1923 arg1Of cells,T
R1678 T1926 T1925 arg2Of compromised,was
R1679 T1927 T1928 arg1Of Taken,together
R1680 T1891 T1892 arg1Of lack,of
R1681 T1931 T1930 arg1Of results,these
R1682 T1931 T1932 arg1Of results,reveal
R1683 T1931 T1944 arg1Of results,suggest
R1684 T1932 T1943 arg1Of reveal,and
R1685 T1934 T1935 arg1Of SHARPIN,is
R1686 T1935 T1932 arg2Of is,reveal
R1687 T1935 T1933 arg1Of is,that
R1688 T1935 T1940 arg1Of is,in
R1689 T1891 T1897 arg1Of lack,caused
R1690 T1894 T1892 arg2Of protein,of
R1691 T1939 T1935 arg2Of molecule,is
R1692 T1939 T1936 arg1Of molecule,a
R1693 T1939 T1937 arg1Of molecule,novel
R1694 T1939 T1938 arg1Of molecule,regulatory
R1695 T1942 T1940 arg2Of biology,in
R1696 T1942 T1941 arg1Of biology,DC
R1697 T1943 T1927 modOf and,Taken
R1698 T1943 T1929 arg1Of and,","
R1699 T1944 T1943 arg2Of suggest,and
R1700 T1894 T1893 arg1Of protein,SHARPIN
R1701 T1894 T1895 arg1Of protein,in
R1702 T1896 T1895 arg2Of BMDC,in
R1703 T1948 T1946 arg1Of function,the
R1704 T1948 T1947 arg2Of function,dysregulated
R1705 T1948 T1949 arg1Of function,of
R1706 T1948 T1952 arg1Of function,plays
R1707 T1897 T1889 arg2Of caused,found
R1708 T1951 T1949 arg2Of DC,of
R1709 T1951 T1950 arg1Of DC,SHARPIN-deficient
R1710 T1952 T1944 arg2Of plays,suggest
R1711 T1952 T1945 arg1Of plays,that
R1712 T1952 T1955 arg1Of plays,in
R1713 T1897 T1890 arg1Of caused,that
R1714 T1954 T1952 arg2Of role,plays
R1715 T1954 T1953 arg1Of role,a
R1716 T1899 T1898 arg1Of expression,defective
R1717 T1958 T1955 arg2Of phenotype,in
R1718 T1958 T1956 arg1Of phenotype,the
R1719 T1958 T1957 arg1Of phenotype,cpdm
R1720 T1899 T1900 arg1Of expression,of
R1721 T1899 T1903 arg1Of expression,and

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T1959 127-139 Anaphor denotes this protein
T1960 13-20 Antecedent denotes SHARPIN
T1961 432-436 Anaphor denotes mRNA
T1962 239-246 Antecedent denotes Sharpin
T1963 462-490 Anaphor denotes a functional protein product
R1725 T1963 T1962 boundBy a functional protein product,Sharpin
R1723 T1959 T1960 boundBy this protein,SHARPIN
R1724 T1961 T1962 boundBy mRNA,Sharpin

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T1013 2182-2188 JJ denotes immune
T1014 2189-2198 NNS denotes responses
T1015 2199-2201 CC denotes or
T1016 2202-2211 NN denotes tolerance
T1017 2211-2212 . denotes .
T1018 2213-2215 NNP denotes DC
T1019 2216-2222 JJ denotes direct
T1020 2223-2226 DT denotes the
T1021 2227-2242 NN denotes differentiation
T1022 2243-2245 IN denotes of
T1023 2246-2249 CD denotes CD4
T1024 2249-2250 CD denotes +
T1025 2251-2252 NNP denotes T
T1026 2253-2258 NNS denotes cells
T1027 2258-2259 , denotes ,
T1028 2260-2263 CC denotes and
T1029 2264-2269 RB denotes hence
T1030 2270-2273 DT denotes the
T1031 2274-2278 NN denotes type
T1032 2279-2281 IN denotes of
T1033 2282-2288 JJ denotes immune
T1034 2289-2297 NN denotes response
T1035 2297-2298 , denotes ,
T1036 2299-2306 IN denotes through
T1037 2307-2310 DT denotes the
T1038 2311-2320 JJ denotes selective
T1039 2321-2330 NN denotes secretion
T1040 2331-2333 IN denotes of
T1041 2334-2343 NNS denotes cytokines
T1042 2343-2344 . denotes .
T1043 2345-2347 PRP denotes We
T1044 2348-2360 VBD denotes hypothesized
T1045 2361-2365 IN denotes that
T1046 2366-2375 JJ denotes defective
T1047 2376-2384 NN denotes cytokine
T1048 2385-2394 NN denotes secretion
T1049 2395-2397 IN denotes by
T1050 2398-2400 NNP denotes DC
T1051 2401-2412 VBD denotes contributed
T1052 2413-2415 TO denotes to
T1053 2416-2419 DT denotes the
T1054 2420-2430 JJ denotes Th2-biased
T1055 2431-2443 JJ denotes inflammatory
T1115 2822-2823 DT denotes a
T1116 2824-2829 JJ denotes novel
T1117 13-20 NNP denotes SHARPIN
T1118 21-24 VBD denotes was
T1119 25-35 RB denotes originally
T1120 36-46 VBN denotes identified
T1121 47-49 IN denotes in
T1122 50-63 JJ denotes post-synaptic
T1123 64-73 NNS denotes densities
T1124 74-76 IN denotes of
T1125 77-87 JJ denotes excitatory
T1126 88-96 NNS denotes synapses
T1127 97-99 IN denotes in
T1128 100-103 DT denotes the
T1129 104-109 NN denotes brain
T1130 110-112 IN denotes of
T1131 113-117 NNS denotes rats
T1132 118-119 VBP denotes [
T1133 119-120 CD denotes 1
T1134 120-121 NNP denotes ]
T1135 121-122 , denotes ,
T1136 123-126 CC denotes but
T1137 127-131 DT denotes this
T1138 132-139 NN denotes protein
T1139 140-142 VBZ denotes is
T1140 143-149 RB denotes widely
T1141 150-159 VBN denotes expressed
T1142 160-162 IN denotes in
T1143 163-164 DT denotes a
T1144 165-172 NN denotes variety
T1145 173-175 IN denotes of
T1146 176-183 NNS denotes tissues
T1147 184-185 NNP denotes [
T1148 185-186 CD denotes 2
T1149 186-187 NNP denotes ]
T1150 187-188 . denotes .
T1151 189-192 CD denotes Two
T1152 193-200 JJ denotes allelic
T1153 200-201 , denotes ,
T1154 202-211 JJ denotes autosomal
T1155 212-221 JJ denotes recessive
T1156 222-231 NNS denotes mutations
T1157 232-234 IN denotes in
T1158 235-238 DT denotes the
T1159 239-246 NNP denotes Sharpin
T1160 247-251 NN denotes gene
T1161 252-260 VBD denotes occurred
T1162 261-274 RB denotes spontaneously
T1163 275-277 IN denotes in
T1164 278-281 CD denotes two
T1165 282-288 JJ denotes inbred
T1166 289-296 NNS denotes strains
T1167 297-299 IN denotes of
T1168 300-304 NNS denotes mice
T1169 304-305 , denotes ,
T1170 306-343 NN denotes C57B/KaLawRij-Sharpincpdm/Sharpincpdm
T1171 344-347 CC denotes and
T1172 348-356 JJ denotes CBy.Ocb3
T1173 356-357 NN denotes /
T1174 357-392 NN denotes Dem-Sharpincpdm-Dem/Sharpincpdm-Dem
T1175 392-393 , denotes ,
T1176 394-403 VBG denotes resulting
T1177 404-406 IN denotes in
T1178 407-416 JJ denotes premature
T1179 417-428 NN denotes termination
T1180 429-431 IN denotes of
T1181 432-436 NNP denotes mRNA
T1182 437-446 NN denotes synthesis
T1183 447-450 CC denotes and
T1184 451-458 NN denotes absence
T1185 459-461 IN denotes of
T1186 462-463 DT denotes a
T1187 464-474 JJ denotes functional
T1188 475-482 NN denotes protein
T1189 483-490 NN denotes product
T1190 491-492 NNP denotes [
T1191 492-493 CD denotes 2
T1192 493-494 NNP denotes ]
T1193 494-495 . denotes .
T1194 496-503 IN denotes Despite
T1195 504-513 JJ denotes different
T1196 514-521 JJ denotes genetic
T1197 522-533 NNS denotes backgrounds
T1198 533-534 , denotes ,
T1199 535-539 DT denotes both
T1200 540-549 NNS denotes mutations
T1201 550-555 VBP denotes cause
T1202 556-563 JJ denotes similar
T1203 564-576 JJ denotes inflammatory
T1204 577-584 NN denotes disease
T1205 585-589 IN denotes with
T1206 590-596 JJ denotes severe
T1207 597-604 NN denotes chronic
T1208 605-616 JJ denotes progressive
T1209 617-627 NN denotes dermatitis
T1210 628-631 CC denotes and
T1211 632-641 JJ denotes defective
T1212 642-653 NN denotes development
T1213 654-656 IN denotes of
T1214 657-666 JJ denotes secondary
T1215 667-675 JJ denotes lymphoid
T1216 676-682 NNS denotes organs
T1217 683-684 VBP denotes [
T1218 684-685 CD denotes 2
T1219 685-686 JJ denotes ]
T1220 687-688 NN denotes [
T1221 688-689 CD denotes 4
T1222 689-690 NNP denotes ]
T1223 690-691 . denotes .
T1224 692-695 DT denotes The
T1225 696-706 NN denotes dermatitis
T1226 707-714 VBZ denotes becomes
T1227 715-725 RB denotes clinically
T1228 726-734 JJ denotes apparent
T1229 735-737 IN denotes at
T1230 738-743 IN denotes about
T1231 744-748 CD denotes four
T1232 749-754 NNS denotes weeks
T1233 755-757 IN denotes of
T1234 758-761 NN denotes age
T1235 761-762 . denotes .
T1236 763-768 EX denotes There
T1237 769-772 VBP denotes are
T1238 773-786 NNS denotes accumulations
T1239 787-789 IN denotes of
T1240 790-801 NNS denotes eosinophils
T1241 801-802 , denotes ,
T1242 803-814 NNS denotes neutrophils
T1243 815-818 CC denotes and
T1244 819-830 NNS denotes macrophages
T1245 831-833 IN denotes in
T1246 834-837 DT denotes the
T1247 838-842 NN denotes skin
T1248 843-845 IN denotes of
T1249 846-869 NNP denotes Sharpincpdm/Sharpincpdm
T1250 870-876 JJ denotes mutant
T1251 877-881 NNS denotes mice
T1252 882-883 -LRB- denotes (
T1253 883-892 NN denotes hereafter
T1254 893-901 VBD denotes referred
T1255 902-904 TO denotes to
T1256 905-907 IN denotes as
T1257 908-912 NN denotes cpdm
T1258 913-917 NNS denotes mice
T1259 917-918 -RRB- denotes )
T1260 919-929 VBN denotes associated
T1261 930-934 IN denotes with
T1262 935-944 VBN denotes increased
T1263 945-955 NN denotes expression
T1264 956-958 IN denotes of
T1265 959-962 JJ denotes Th2
T1266 963-972 NNS denotes cytokines
T1267 973-975 IN denotes in
T1268 976-979 DT denotes the
T1269 980-984 NN denotes skin
T1270 985-988 CC denotes and
T1271 989-991 IN denotes in
T1272 992-995 DT denotes the
T1273 996-1008 NNS denotes supernatants
T1274 1009-1011 IN denotes of
T1275 1012-1021 VBN denotes activated
T1276 1022-1033 NNS denotes splenocytes
T1277 1034-1035 VBP denotes [
T1278 1035-1036 CD denotes 5
T1279 1036-1037 NNP denotes ]
T1280 1037-1038 . denotes .
T1281 1039-1042 DT denotes The
T1282 1043-1047 NNS denotes mice
T1283 1048-1052 VBP denotes have
T1284 1053-1055 DT denotes an
T1285 1056-1064 JJ denotes impaired
T1286 1065-1072 JJ denotes delayed
T1287 1073-1077 NN denotes type
T1288 1078-1094 NN denotes hypersensitivity
T1289 1095-1103 NN denotes response
T1290 1104-1107 CC denotes and
T1291 1108-1117 VBD denotes decreased
T1292 1118-1127 NN denotes secretion
T1293 1128-1130 IN denotes of
T1294 1131-1135 NNP denotes IFNγ
T1295 1136-1137 NNP denotes [
T1296 1137-1138 CD denotes 5
T1297 1138-1139 NNP denotes ]
T1298 1139-1140 , denotes ,
T1299 1141-1151 VBG denotes indicating
T1300 1152-1153 DT denotes a
T1301 1154-1160 NN denotes defect
T1302 1161-1163 IN denotes in
T1303 1164-1167 CD denotes Th1
T1304 1168-1174 JJ denotes immune
T1305 1175-1184 NNS denotes responses
T1306 1185-1188 CC denotes and
T1307 1189-1190 DT denotes a
T1308 1191-1195 NN denotes bias
T1309 1196-1203 IN denotes towards
T1310 1204-1205 DT denotes a
T1311 1206-1209 JJ denotes Th2
T1312 1210-1216 JJ denotes immune
T1313 1217-1225 NN denotes response
T1314 1225-1226 . denotes .
T1315 1227-1235 JJ denotes Systemic
T1316 1236-1245 NN denotes treatment
T1317 1246-1248 IN denotes of
T1318 1249-1253 NN denotes cpdm
T1319 1254-1258 NNS denotes mice
T1320 1259-1263 IN denotes with
T1321 1264-1275 JJ denotes recombinant
T1322 1276-1280 NNP denotes IL12
T1323 1281-1287 VBD denotes caused
T1324 1288-1296 JJ denotes complete
T1325 1297-1306 NN denotes remission
T1326 1307-1309 IN denotes of
T1327 1310-1313 DT denotes the
T1328 1314-1324 NN denotes dermatitis
T1329 1325-1326 NN denotes [
T1330 1326-1327 CD denotes 5
T1331 1327-1328 NNP denotes ]
T1332 1328-1329 . denotes .
T1333 1330-1344 NN denotes Neutralization
T1334 1345-1347 IN denotes of
T1335 1348-1351 CD denotes IL5
T1336 1352-1354 IN denotes by
T1337 1355-1363 NN denotes antibody
T1338 1364-1373 NN denotes treatment
T1339 1374-1376 CC denotes or
T1340 1377-1384 NNS denotes crosses
T1341 1385-1389 IN denotes with
T1342 1390-1403 JJ denotes IL5-deficient
T1343 1404-1408 NNS denotes mice
T1344 1409-1416 VBD denotes reduced
T1345 1417-1420 DT denotes the
T1346 1421-1427 NN denotes number
T1347 1428-1430 IN denotes of
T1348 1431-1442 VBG denotes circulating
T1349 1443-1446 CC denotes and
T1350 1447-1456 JJ denotes cutaneous
T1351 1457-1468 NNS denotes eosinophils
T1352 1468-1469 , denotes ,
T1353 1470-1473 CC denotes but
T1354 1474-1480 VBD denotes failed
T1355 1481-1483 TO denotes to
T1356 1484-1490 VB denotes reduce
T1357 1491-1494 DT denotes the
T1358 1495-1500 NN denotes onset
T1359 1501-1504 CC denotes and
T1360 1505-1513 NN denotes severity
T1361 1514-1516 IN denotes of
T1362 1517-1520 DT denotes the
T1363 1521-1531 NN denotes dermatitis
T1364 1532-1533 NN denotes [
T1365 1533-1534 CD denotes 6
T1366 1534-1535 NNP denotes ]
T1367 1535-1536 . denotes .
T1368 1537-1545 RB denotes Recently
T1369 1545-1546 , denotes ,
T1370 1547-1552 CD denotes three
T1371 1553-1564 JJ denotes independent
T1372 1565-1571 NNS denotes groups
T1373 1572-1582 VBN denotes identified
T1374 1583-1590 NNP denotes SHARPIN
T1375 1591-1593 IN denotes as
T1376 1594-1596 DT denotes an
T1377 1597-1606 JJ denotes essential
T1378 1607-1616 NN denotes component
T1379 1617-1619 IN denotes of
T1380 1620-1623 DT denotes the
T1381 1624-1630 JJ denotes linear
T1382 1631-1640 NN denotes ubiquitin
T1383 1641-1646 NN denotes chain
T1384 1647-1655 NN denotes assembly
T1385 1656-1663 NN denotes complex
T1386 1664-1665 -LRB- denotes (
T1387 1665-1670 NNP denotes LUBAC
T1388 1670-1671 -RRB- denotes )
T1389 1672-1676 WDT denotes that
T1390 1677-1686 VBZ denotes regulates
T1391 1687-1699 JJ denotes TNFα-induced
T1392 1700-1709 JJ denotes canonical
T1393 1710-1715 NN denotes NF-κB
T1394 1716-1725 VBG denotes signaling
T1395 1726-1727 NNP denotes [
T1396 1727-1728 CD denotes 7
T1397 1728-1729 NNP denotes ]
T1398 1730-1731 NN denotes [
T1399 1731-1732 CD denotes 9
T1400 1732-1733 NNP denotes ]
T1401 1733-1734 . denotes .
T1402 1735-1752 JJ denotes SHARPIN-deficient
T1403 1753-1758 NN denotes mouse
T1404 1759-1768 JJ denotes embryonic
T1405 1769-1779 NN denotes fibroblast
T1406 1780-1781 -LRB- denotes (
T1407 1781-1784 NNP denotes MEF
T1408 1784-1785 -RRB- denotes )
T1409 1786-1790 VBD denotes were
T1410 1791-1801 VBN denotes sensitized
T1411 1802-1804 TO denotes to
T1412 1805-1817 JJ denotes TNFα-induced
T1413 1818-1827 NN denotes apoptosis
T1414 1828-1831 CC denotes and
T1415 1832-1836 NN denotes cell
T1416 1837-1842 NN denotes death
T1417 1843-1846 VBD denotes was
T1418 1847-1857 VBN denotes implicated
T1419 1858-1860 IN denotes as
T1420 1861-1862 DT denotes a
T1421 1863-1869 NN denotes factor
T1422 1870-1872 IN denotes in
T1423 1873-1876 DT denotes the
T1424 1877-1887 NN denotes dermatitis
T1425 1888-1890 IN denotes of
T1426 1891-1895 NN denotes cpdm
T1427 1896-1900 NNS denotes mice
T1428 1901-1902 VBP denotes [
T1429 1902-1903 CD denotes 7
T1430 1903-1904 NNP denotes ]
T1431 1905-1906 NN denotes [
T1432 1906-1907 CD denotes 9
T1433 1907-1908 NNP denotes ]
T1434 1908-1909 . denotes .
T1435 1910-1919 JJ denotes Dendritic
T1436 1920-1925 NNS denotes cells
T1437 1926-1927 -LRB- denotes (
T1438 1927-1929 NNP denotes DC
T1439 1929-1930 -RRB- denotes )
T1440 1931-1935 VBP denotes have
T1441 1936-1937 DT denotes a
T1442 1938-1946 NN denotes sentinel
T1443 1947-1951 NN denotes role
T1444 1952-1954 IN denotes in
T1445 1955-1962 VBG denotes sensing
T1446 1963-1971 NN denotes pathogen
T1447 1972-1974 CC denotes or
T1448 1975-1981 NN denotes danger
T1449 1982-1989 NNS denotes signals
T1450 1990-1993 CC denotes and
T1451 1994-2002 NN denotes initiate
T1452 2003-2006 CC denotes and
T1453 2007-2013 JJ denotes direct
T1454 2014-2024 NN denotes activation
T1455 2025-2027 IN denotes of
T1456 2028-2031 DT denotes the
T1457 2032-2040 JJ denotes adaptive
T1458 2041-2047 JJ denotes immune
T1459 2048-2056 NN denotes response
T1460 2057-2058 NNP denotes [
T1461 2058-2060 CD denotes 10
T1462 2060-2061 NNP denotes ]
T1463 2061-2062 . denotes .
T1464 2830-2840 JJ denotes regulatory
T1465 2841-2849 NN denotes molecule
T1466 2850-2852 IN denotes in
T1467 2853-2855 NNP denotes DC
T1468 2856-2863 NN denotes biology
T1469 2864-2867 CC denotes and
T1470 2868-2875 VBP denotes suggest
T1471 2876-2880 IN denotes that
T1472 2881-2884 DT denotes the
T1473 2885-2897 JJ denotes dysregulated
T1474 2898-2906 NN denotes function
T1475 2907-2909 IN denotes of
T1476 2910-2927 JJ denotes SHARPIN-deficient
T1477 2928-2930 NNP denotes DC
T1478 2931-2936 VBZ denotes plays
T1479 2937-2938 DT denotes a
T1480 2939-2943 NN denotes role
T1481 2944-2946 IN denotes in
T1482 2947-2950 DT denotes the
T1483 2951-2955 NN denotes cpdm
T1484 2956-2965 NN denotes phenotype
T1485 2965-2966 . denotes .
T995 2063-2072 VBN denotes Activated
T996 2073-2076 CC denotes and
T997 2077-2083 VBP denotes mature
T998 2084-2086 NNP denotes DC
T999 2087-2090 MD denotes can
T1000 2091-2096 VB denotes carry
T1001 2097-2106 VBN denotes processed
T1002 2107-2116 JJ denotes antigenic
T1003 2117-2125 NNS denotes peptides
T1004 2125-2126 , denotes ,
T1005 2127-2134 VB denotes migrate
T1006 2135-2137 TO denotes to
T1007 2138-2146 JJ denotes lymphoid
T1008 2147-2153 NNS denotes organs
T1009 2153-2154 , denotes ,
T1010 2155-2158 CC denotes and
T1011 2159-2165 VB denotes induce
T1012 2166-2181 JJ denotes T-cell-mediated
T1056 2444-2453 NN denotes phenotype
T1057 2454-2456 IN denotes in
T1058 2457-2474 JJ denotes SHARPIN-deficient
T1059 2475-2479 NNS denotes mice
T1060 2479-2480 . denotes .
T1061 2481-2484 DT denotes The
T1062 2485-2492 NNS denotes studies
T1063 2493-2501 VBD denotes reported
T1064 2502-2506 RB denotes here
T1065 2507-2512 VBN denotes found
T1066 2513-2517 IN denotes that
T1067 2518-2522 NN denotes lack
T1068 2523-2525 IN denotes of
T1069 2526-2533 NNP denotes SHARPIN
T1070 2534-2541 NN denotes protein
T1071 2542-2544 IN denotes in
T1072 2545-2549 NNP denotes BMDC
T1073 2550-2556 VBD denotes caused
T1074 2557-2566 JJ denotes defective
T1075 2567-2577 NN denotes expression
T1076 2578-2580 IN denotes of
T1077 2581-2597 JJ denotes pro-inflammatory
T1078 2598-2607 NNS denotes mediators
T1079 2608-2611 CC denotes and
T1080 2612-2620 VBN denotes impaired
T1081 2621-2626 JJ denotes NF-κB
T1082 2627-2637 NN denotes activation
T1083 2638-2642 IN denotes upon
T1084 2643-2649 NN denotes ligand
T1085 2650-2661 NN denotes stimulation
T1086 2661-2662 . denotes .
T1087 2663-2666 DT denotes The
T1088 2667-2674 NN denotes ability
T1089 2675-2677 IN denotes of
T1090 2678-2682 NN denotes cpdm
T1091 2683-2687 NNP denotes BMDC
T1092 2688-2690 TO denotes to
T1093 2691-2700 VB denotes stimulate
T1094 2701-2704 JJ denotes Th1
T1095 2705-2713 NN denotes cytokine
T1096 2714-2724 NN denotes production
T1097 2725-2727 IN denotes in
T1098 2728-2738 JJ denotes allogeneic
T1099 2739-2742 NNP denotes CD4
T1100 2742-2743 CD denotes +
T1101 2744-2745 NNP denotes T
T1102 2746-2751 NNS denotes cells
T1103 2752-2755 VBD denotes was
T1104 2756-2767 VBN denotes compromised
T1105 2767-2768 . denotes .
T1106 2769-2774 VBN denotes Taken
T1107 2775-2783 RB denotes together
T1108 2783-2784 , denotes ,
T1109 2785-2790 DT denotes these
T1110 2791-2798 NNS denotes results
T1111 2799-2805 VBP denotes reveal
T1112 2806-2810 IN denotes that
T1113 2811-2818 NNP denotes SHARPIN
T1114 2819-2821 VBZ denotes is
R757 T995 T1000 advcl Activated,carry
R758 T996 T995 cc and,Activated
R759 T997 T995 conj mature,Activated
R760 T998 T1000 nsubj DC,carry
R761 T999 T1000 aux can,carry
R762 T1000 T1000 ROOT carry,carry
R763 T1001 T1003 amod processed,peptides
R764 T1002 T1003 amod antigenic,peptides
R765 T1003 T1000 dobj peptides,carry
R766 T1004 T1000 punct ",",carry
R767 T1005 T1000 conj migrate,carry
R768 T1006 T1005 prep to,migrate
R769 T1007 T1008 amod lymphoid,organs
R770 T1008 T1006 pobj organs,to
R771 T1009 T1005 punct ",",migrate
R772 T1010 T1005 cc and,migrate
R773 T1011 T1005 conj induce,migrate
R774 T1012 T1014 amod T-cell-mediated,responses
R775 T1013 T1014 amod immune,responses
R776 T1014 T1011 dobj responses,induce
R777 T1015 T1014 cc or,responses
R778 T1016 T1014 conj tolerance,responses
R779 T1017 T1000 punct .,carry
R780 T1018 T1018 ROOT DC,DC
R781 T1019 T1036 amod direct,through
R782 T1020 T1021 det the,differentiation
R783 T1021 T1019 dobj differentiation,direct
R784 T1022 T1021 prep of,differentiation
R785 T1023 T1026 nummod CD4,cells
R786 T1024 T1026 nummod +,cells
R787 T1025 T1026 compound T,cells
R788 T1026 T1022 pobj cells,of
R789 T1027 T1021 punct ",",differentiation
R790 T1028 T1021 cc and,differentiation
R791 T1029 T1031 advmod hence,type
R792 T1030 T1031 det the,type
R793 T1031 T1021 conj type,differentiation
R794 T1032 T1031 prep of,type
R795 T1033 T1034 amod immune,response
R796 T1034 T1032 pobj response,of
R797 T1035 T1031 punct ",",type
R798 T1036 T1018 prep through,DC
R799 T1037 T1039 det the,secretion
R800 T1038 T1039 amod selective,secretion
R801 T1039 T1036 pobj secretion,through
R802 T1040 T1039 prep of,secretion
R803 T1041 T1040 pobj cytokines,of
R804 T1042 T1018 punct .,DC
R805 T1043 T1044 nsubj We,hypothesized
R806 T1044 T1044 ROOT hypothesized,hypothesized
R807 T1045 T1051 mark that,contributed
R808 T1046 T1048 amod defective,secretion
R809 T1047 T1048 compound cytokine,secretion
R810 T1048 T1051 nsubj secretion,contributed
R811 T1049 T1048 prep by,secretion
R812 T1050 T1049 pobj DC,by
R813 T1051 T1044 ccomp contributed,hypothesized
R814 T1052 T1051 prep to,contributed
R815 T1053 T1056 det the,phenotype
R816 T1054 T1056 amod Th2-biased,phenotype
R817 T1055 T1056 amod inflammatory,phenotype
R818 T1056 T1052 pobj phenotype,to
R819 T1057 T1056 prep in,phenotype
R820 T1058 T1059 amod SHARPIN-deficient,mice
R821 T1059 T1057 pobj mice,in
R822 T1060 T1044 punct .,hypothesized
R823 T1061 T1062 det The,studies
R824 T1062 T1065 nsubj studies,found
R825 T1063 T1062 acl reported,studies
R826 T1064 T1063 advmod here,reported
R827 T1065 T1065 ROOT found,found
R828 T1066 T1073 mark that,caused
R829 T1067 T1073 nsubj lack,caused
R830 T1068 T1067 prep of,lack
R831 T1069 T1070 compound SHARPIN,protein
R832 T1070 T1068 pobj protein,of
R833 T1071 T1067 prep in,lack
R834 T1072 T1071 pobj BMDC,in
R835 T1073 T1065 ccomp caused,found
R836 T1074 T1075 amod defective,expression
R837 T1075 T1073 dobj expression,caused
R838 T1076 T1075 prep of,expression
R839 T1077 T1078 amod pro-inflammatory,mediators
R840 T1078 T1076 pobj mediators,of
R841 T1079 T1075 cc and,expression
R842 T1080 T1082 amod impaired,activation
R843 T1081 T1082 amod NF-κB,activation
R844 T1082 T1075 conj activation,expression
R845 T1083 T1082 prep upon,activation
R846 T1084 T1085 amod ligand,stimulation
R847 T1085 T1083 pobj stimulation,upon
R848 T1086 T1065 punct .,found
R849 T1087 T1088 det The,ability
R850 T1088 T1104 nsubjpass ability,compromised
R851 T1089 T1088 prep of,ability
R852 T1090 T1091 compound cpdm,BMDC
R853 T1091 T1089 pobj BMDC,of
R854 T1092 T1093 aux to,stimulate
R855 T1093 T1088 acl stimulate,ability
R856 T1094 T1096 amod Th1,production
R857 T1095 T1096 compound cytokine,production
R858 T1096 T1093 dobj production,stimulate
R859 T1097 T1096 prep in,production
R860 T1098 T1099 amod allogeneic,CD4
R861 T1099 T1101 compound CD4,T
R862 T1100 T1101 compound +,T
R863 T1101 T1102 compound T,cells
R864 T1102 T1097 pobj cells,in
R865 T1103 T1104 auxpass was,compromised
R866 T1104 T1104 ROOT compromised,compromised
R867 T1105 T1104 punct .,compromised
R868 T1106 T1111 advcl Taken,reveal
R869 T1107 T1106 advmod together,Taken
R870 T1108 T1111 punct ",",reveal
R871 T1109 T1110 det these,results
R872 T1110 T1111 nsubj results,reveal
R873 T1111 T1111 ROOT reveal,reveal
R874 T1112 T1114 mark that,is
R875 T1113 T1114 nsubj SHARPIN,is
R876 T1114 T1111 ccomp is,reveal
R877 T1115 T1465 det a,molecule
R878 T1116 T1465 amod novel,molecule
R879 T1117 T1120 nsubjpass SHARPIN,identified
R880 T1118 T1120 auxpass was,identified
R881 T1119 T1120 advmod originally,identified
R882 T1120 T1120 ROOT identified,identified
R883 T1121 T1120 prep in,identified
R884 T1122 T1123 amod post-synaptic,densities
R885 T1123 T1121 pobj densities,in
R886 T1124 T1123 prep of,densities
R887 T1125 T1126 amod excitatory,synapses
R888 T1126 T1124 pobj synapses,of
R889 T1127 T1120 prep in,identified
R890 T1128 T1129 det the,brain
R891 T1129 T1127 pobj brain,in
R892 T1130 T1129 prep of,brain
R893 T1131 T1130 pobj rats,of
R894 T1132 T1134 nmod [,]
R895 T1133 T1134 nummod 1,]
R896 T1134 T1134 ROOT ],]
R897 T1135 T1134 punct ",",]
R898 T1136 T1141 cc but,expressed
R899 T1137 T1138 det this,protein
R900 T1138 T1141 nsubjpass protein,expressed
R901 T1139 T1141 auxpass is,expressed
R902 T1140 T1141 advmod widely,expressed
R903 T1141 T1134 parataxis expressed,]
R904 T1142 T1141 prep in,expressed
R905 T1143 T1144 det a,variety
R906 T1144 T1142 pobj variety,in
R907 T1145 T1144 prep of,variety
R908 T1146 T1145 pobj tissues,of
R909 T1147 T1149 nmod [,]
R910 T1148 T1149 nummod 2,]
R911 T1149 T1144 appos ],variety
R912 T1150 T1141 punct .,expressed
R913 T1151 T1156 nummod Two,mutations
R914 T1152 T1156 amod allelic,mutations
R915 T1153 T1156 punct ",",mutations
R916 T1154 T1156 amod autosomal,mutations
R917 T1155 T1156 amod recessive,mutations
R918 T1156 T1161 nsubj mutations,occurred
R919 T1157 T1156 prep in,mutations
R920 T1158 T1160 det the,gene
R921 T1159 T1160 compound Sharpin,gene
R922 T1160 T1157 pobj gene,in
R923 T1161 T1161 ROOT occurred,occurred
R924 T1162 T1161 advmod spontaneously,occurred
R925 T1163 T1161 prep in,occurred
R926 T1164 T1166 nummod two,strains
R927 T1165 T1166 amod inbred,strains
R928 T1166 T1163 pobj strains,in
R929 T1167 T1166 prep of,strains
R930 T1168 T1167 pobj mice,of
R931 T1169 T1166 punct ",",strains
R932 T1170 T1166 appos C57B/KaLawRij-Sharpincpdm/Sharpincpdm,strains
R933 T1171 T1170 cc and,C57B/KaLawRij-Sharpincpdm/Sharpincpdm
R934 T1172 T1174 amod CBy.Ocb3,Dem-Sharpincpdm-Dem/Sharpincpdm-Dem
R935 T1173 T1174 compound /,Dem-Sharpincpdm-Dem/Sharpincpdm-Dem
R936 T1174 T1170 conj Dem-Sharpincpdm-Dem/Sharpincpdm-Dem,C57B/KaLawRij-Sharpincpdm/Sharpincpdm
R937 T1175 T1166 punct ",",strains
R938 T1176 T1161 advcl resulting,occurred
R939 T1177 T1176 prep in,resulting
R940 T1178 T1179 amod premature,termination
R941 T1179 T1177 pobj termination,in
R942 T1180 T1179 prep of,termination
R943 T1181 T1182 compound mRNA,synthesis
R944 T1182 T1180 pobj synthesis,of
R945 T1183 T1182 cc and,synthesis
R946 T1184 T1182 conj absence,synthesis
R947 T1185 T1184 prep of,absence
R948 T1186 T1189 det a,product
R949 T1187 T1188 amod functional,protein
R950 T1188 T1189 compound protein,product
R951 T1189 T1185 pobj product,of
R952 T1190 T1192 nmod [,]
R953 T1191 T1192 nummod 2,]
R954 T1192 T1176 dobj ],resulting
R955 T1193 T1161 punct .,occurred
R956 T1194 T1201 prep Despite,cause
R957 T1195 T1197 amod different,backgrounds
R958 T1196 T1197 amod genetic,backgrounds
R959 T1197 T1194 pobj backgrounds,Despite
R960 T1198 T1201 punct ",",cause
R961 T1199 T1200 det both,mutations
R962 T1200 T1201 nsubj mutations,cause
R963 T1201 T1201 ROOT cause,cause
R964 T1202 T1204 amod similar,disease
R965 T1203 T1204 amod inflammatory,disease
R966 T1204 T1201 dobj disease,cause
R967 T1205 T1201 prep with,cause
R968 T1206 T1209 amod severe,dermatitis
R969 T1207 T1209 amod chronic,dermatitis
R970 T1208 T1209 amod progressive,dermatitis
R971 T1209 T1205 pobj dermatitis,with
R972 T1210 T1209 cc and,dermatitis
R973 T1211 T1212 amod defective,development
R974 T1212 T1209 conj development,dermatitis
R975 T1213 T1212 prep of,development
R976 T1214 T1216 amod secondary,organs
R977 T1215 T1216 amod lymphoid,organs
R978 T1216 T1213 pobj organs,of
R979 T1217 T1219 nmod [,]
R980 T1218 T1219 nummod 2,]
R981 T1219 T1220 meta ],[
R982 T1220 T1222 nmod [,]
R983 T1221 T1222 nummod 4,]
R984 T1222 T1201 npadvmod ],cause
R985 T1223 T1201 punct .,cause
R986 T1224 T1225 det The,dermatitis
R987 T1225 T1226 nsubj dermatitis,becomes
R988 T1226 T1226 ROOT becomes,becomes
R989 T1227 T1228 advmod clinically,apparent
R990 T1228 T1226 acomp apparent,becomes
R991 T1229 T1226 prep at,becomes
R992 T1230 T1231 quantmod about,four
R993 T1231 T1232 nummod four,weeks
R994 T1232 T1229 pobj weeks,at
R995 T1233 T1232 prep of,weeks
R996 T1234 T1233 pobj age,of
R997 T1235 T1226 punct .,becomes
R998 T1236 T1237 expl There,are
R999 T1237 T1237 ROOT are,are
R1000 T1238 T1237 attr accumulations,are
R1001 T1239 T1238 prep of,accumulations
R1002 T1240 T1239 pobj eosinophils,of
R1003 T1241 T1240 punct ",",eosinophils
R1004 T1242 T1240 conj neutrophils,eosinophils
R1005 T1243 T1242 cc and,neutrophils
R1006 T1244 T1242 conj macrophages,neutrophils
R1007 T1245 T1238 prep in,accumulations
R1008 T1246 T1247 det the,skin
R1009 T1247 T1245 pobj skin,in
R1010 T1248 T1247 prep of,skin
R1011 T1249 T1251 nmod Sharpincpdm/Sharpincpdm,mice
R1012 T1250 T1251 amod mutant,mice
R1013 T1251 T1248 pobj mice,of
R1014 T1252 T1254 punct (,referred
R1015 T1253 T1254 nsubj hereafter,referred
R1016 T1254 T1237 parataxis referred,are
R1017 T1255 T1254 prep to,referred
R1018 T1256 T1254 prep as,referred
R1019 T1257 T1258 compound cpdm,mice
R1020 T1258 T1256 pobj mice,as
R1021 T1259 T1254 punct ),referred
R1022 T1260 T1237 conj associated,are
R1023 T1261 T1260 prep with,associated
R1024 T1262 T1263 amod increased,expression
R1025 T1263 T1261 pobj expression,with
R1026 T1264 T1263 prep of,expression
R1027 T1265 T1266 amod Th2,cytokines
R1028 T1266 T1264 pobj cytokines,of
R1029 T1267 T1266 prep in,cytokines
R1030 T1268 T1269 det the,skin
R1031 T1269 T1267 pobj skin,in
R1032 T1270 T1267 cc and,in
R1033 T1271 T1267 conj in,in
R1034 T1272 T1273 det the,supernatants
R1035 T1273 T1271 pobj supernatants,in
R1036 T1274 T1273 prep of,supernatants
R1037 T1275 T1276 amod activated,splenocytes
R1038 T1276 T1274 pobj splenocytes,of
R1039 T1277 T1279 nmod [,]
R1040 T1278 T1279 nummod 5,]
R1041 T1279 T1260 npadvmod ],associated
R1042 T1280 T1260 punct .,associated
R1043 T1281 T1282 det The,mice
R1044 T1282 T1283 nsubj mice,have
R1045 T1283 T1283 ROOT have,have
R1046 T1284 T1287 det an,type
R1047 T1285 T1287 amod impaired,type
R1048 T1286 T1287 amod delayed,type
R1049 T1287 T1283 dobj type,have
R1050 T1288 T1289 amod hypersensitivity,response
R1051 T1289 T1287 dobj response,type
R1052 T1290 T1283 cc and,have
R1053 T1291 T1283 conj decreased,have
R1054 T1292 T1291 dobj secretion,decreased
R1055 T1293 T1292 prep of,secretion
R1056 T1294 T1295 compound IFNγ,[
R1057 T1295 T1297 nmod [,]
R1058 T1296 T1297 nummod 5,]
R1059 T1297 T1293 pobj ],of
R1060 T1298 T1291 punct ",",decreased
R1061 T1299 T1291 advcl indicating,decreased
R1062 T1300 T1301 det a,defect
R1063 T1301 T1299 dobj defect,indicating
R1064 T1302 T1301 prep in,defect
R1065 T1303 T1305 nummod Th1,responses
R1066 T1304 T1305 amod immune,responses
R1067 T1305 T1302 pobj responses,in
R1068 T1306 T1305 cc and,responses
R1069 T1307 T1308 det a,bias
R1070 T1308 T1305 conj bias,responses
R1071 T1309 T1308 prep towards,bias
R1072 T1310 T1313 det a,response
R1073 T1311 T1313 amod Th2,response
R1074 T1312 T1313 amod immune,response
R1075 T1313 T1309 pobj response,towards
R1076 T1314 T1283 punct .,have
R1077 T1315 T1316 amod Systemic,treatment
R1078 T1316 T1323 nsubj treatment,caused
R1079 T1317 T1316 prep of,treatment
R1080 T1318 T1319 compound cpdm,mice
R1081 T1319 T1317 pobj mice,of
R1082 T1320 T1316 prep with,treatment
R1083 T1321 T1322 amod recombinant,IL12
R1084 T1322 T1320 pobj IL12,with
R1085 T1323 T1323 ROOT caused,caused
R1086 T1324 T1325 amod complete,remission
R1087 T1325 T1323 dobj remission,caused
R1088 T1326 T1325 prep of,remission
R1089 T1327 T1329 det the,[
R1090 T1328 T1329 compound dermatitis,[
R1091 T1329 T1326 pobj [,of
R1092 T1330 T1329 nummod 5,[
R1093 T1331 T1329 appos ],[
R1094 T1332 T1323 punct .,caused
R1095 T1333 T1344 nsubj Neutralization,reduced
R1096 T1334 T1333 prep of,Neutralization
R1097 T1335 T1334 pobj IL5,of
R1098 T1336 T1333 prep by,Neutralization
R1099 T1337 T1338 compound antibody,treatment
R1100 T1338 T1336 pobj treatment,by
R1101 T1339 T1338 cc or,treatment
R1102 T1340 T1338 conj crosses,treatment
R1103 T1341 T1333 prep with,Neutralization
R1104 T1342 T1343 amod IL5-deficient,mice
R1105 T1343 T1341 pobj mice,with
R1106 T1344 T1344 ROOT reduced,reduced
R1107 T1345 T1346 det the,number
R1108 T1346 T1344 dobj number,reduced
R1109 T1347 T1346 prep of,number
R1110 T1348 T1347 pobj circulating,of
R1111 T1349 T1348 cc and,circulating
R1112 T1350 T1348 conj cutaneous,circulating
R1113 T1351 T1348 conj eosinophils,circulating
R1114 T1352 T1344 punct ",",reduced
R1115 T1353 T1344 cc but,reduced
R1116 T1354 T1344 conj failed,reduced
R1117 T1355 T1356 aux to,reduce
R1118 T1356 T1354 xcomp reduce,failed
R1119 T1357 T1358 det the,onset
R1120 T1358 T1356 dobj onset,reduce
R1121 T1359 T1358 cc and,onset
R1122 T1360 T1358 conj severity,onset
R1123 T1361 T1358 prep of,onset
R1124 T1362 T1364 det the,[
R1125 T1363 T1364 compound dermatitis,[
R1126 T1364 T1361 pobj [,of
R1127 T1365 T1364 nummod 6,[
R1128 T1366 T1364 appos ],[
R1129 T1367 T1344 punct .,reduced
R1130 T1368 T1373 advmod Recently,identified
R1131 T1369 T1373 punct ",",identified
R1132 T1370 T1372 nummod three,groups
R1133 T1371 T1372 amod independent,groups
R1134 T1372 T1373 nsubj groups,identified
R1135 T1373 T1373 ROOT identified,identified
R1136 T1374 T1373 dobj SHARPIN,identified
R1137 T1375 T1373 prep as,identified
R1138 T1376 T1378 det an,component
R1139 T1377 T1378 amod essential,component
R1140 T1378 T1375 pobj component,as
R1141 T1379 T1378 prep of,component
R1142 T1380 T1385 det the,complex
R1143 T1381 T1385 nmod linear,complex
R1144 T1382 T1385 compound ubiquitin,complex
R1145 T1383 T1385 compound chain,complex
R1146 T1384 T1385 compound assembly,complex
R1147 T1385 T1379 pobj complex,of
R1148 T1386 T1387 punct (,LUBAC
R1149 T1387 T1385 appos LUBAC,complex
R1150 T1388 T1385 punct ),complex
R1151 T1389 T1390 nsubj that,regulates
R1152 T1390 T1378 relcl regulates,component
R1153 T1391 T1393 amod TNFα-induced,NF-κB
R1154 T1392 T1393 amod canonical,NF-κB
R1155 T1393 T1390 dobj NF-κB,regulates
R1156 T1394 T1393 acl signaling,NF-κB
R1157 T1395 T1397 nmod [,]
R1158 T1396 T1397 nummod 7,]
R1159 T1397 T1394 dobj ],signaling
R1160 T1398 T1397 appos [,]
R1161 T1399 T1400 nummod 9,]
R1162 T1400 T1397 conj ],]
R1163 T1401 T1373 punct .,identified
R1164 T1402 T1410 amod SHARPIN-deficient,sensitized
R1165 T1403 T1410 nsubjpass mouse,sensitized
R1166 T1404 T1405 amod embryonic,fibroblast
R1167 T1405 T1403 appos fibroblast,mouse
R1168 T1406 T1407 punct (,MEF
R1169 T1407 T1405 appos MEF,fibroblast
R1170 T1408 T1403 punct ),mouse
R1171 T1409 T1410 auxpass were,sensitized
R1172 T1410 T1410 ROOT sensitized,sensitized
R1173 T1411 T1410 prep to,sensitized
R1174 T1412 T1413 advmod TNFα-induced,apoptosis
R1175 T1413 T1411 pobj apoptosis,to
R1176 T1414 T1413 cc and,apoptosis
R1177 T1415 T1416 compound cell,death
R1178 T1416 T1418 nsubjpass death,implicated
R1179 T1417 T1418 auxpass was,implicated
R1180 T1418 T1410 conj implicated,sensitized
R1181 T1419 T1418 prep as,implicated
R1182 T1420 T1421 det a,factor
R1183 T1421 T1419 pobj factor,as
R1184 T1422 T1421 prep in,factor
R1185 T1423 T1424 det the,dermatitis
R1186 T1424 T1422 pobj dermatitis,in
R1187 T1425 T1424 prep of,dermatitis
R1188 T1426 T1427 compound cpdm,mice
R1189 T1427 T1425 pobj mice,of
R1190 T1428 T1430 nmod [,]
R1191 T1429 T1430 nummod 7,]
R1192 T1430 T1431 nmod ],[
R1193 T1431 T1433 nmod [,]
R1194 T1432 T1433 nummod 9,]
R1195 T1433 T1418 conj ],implicated
R1196 T1434 T1418 punct .,implicated
R1197 T1435 T1436 amod Dendritic,cells
R1198 T1436 T1440 nsubj cells,have
R1199 T1437 T1438 punct (,DC
R1200 T1438 T1436 appos DC,cells
R1201 T1439 T1436 punct ),cells
R1202 T1440 T1440 ROOT have,have
R1203 T1441 T1443 det a,role
R1204 T1442 T1443 compound sentinel,role
R1205 T1443 T1440 dobj role,have
R1206 T1444 T1443 prep in,role
R1207 T1445 T1444 pcomp sensing,in
R1208 T1446 T1445 dobj pathogen,sensing
R1209 T1447 T1446 cc or,pathogen
R1210 T1448 T1446 conj danger,pathogen
R1211 T1449 T1445 dobj signals,sensing
R1212 T1450 T1445 cc and,sensing
R1213 T1451 T1445 conj initiate,sensing
R1214 T1452 T1451 cc and,initiate
R1215 T1453 T1454 amod direct,activation
R1216 T1454 T1451 conj activation,initiate
R1217 T1455 T1454 prep of,activation
R1218 T1456 T1459 det the,response
R1219 T1457 T1459 amod adaptive,response
R1220 T1458 T1459 amod immune,response
R1221 T1459 T1455 pobj response,of
R1222 T1460 T1462 nmod [,]
R1223 T1461 T1462 nummod 10,]
R1224 T1462 T1454 nmod ],activation
R1225 T1463 T1440 punct .,have
R1226 T1464 T1465 amod regulatory,molecule
R1227 T1465 T1114 attr molecule,is
R1228 T1466 T1465 prep in,molecule
R1229 T1467 T1468 compound DC,biology
R1230 T1468 T1466 pobj biology,in
R1231 T1469 T1114 cc and,is
R1232 T1470 T1114 conj suggest,is
R1233 T1471 T1478 mark that,plays
R1234 T1472 T1474 det the,function
R1235 T1473 T1474 amod dysregulated,function
R1236 T1474 T1478 nsubj function,plays
R1237 T1475 T1474 prep of,function
R1238 T1476 T1477 compound SHARPIN-deficient,DC
R1239 T1477 T1475 pobj DC,of
R1240 T1478 T1470 ccomp plays,suggest
R1241 T1479 T1480 det a,role
R1242 T1480 T1478 dobj role,plays
R1243 T1481 T1480 prep in,role
R1244 T1482 T1484 det the,phenotype
R1245 T1483 T1484 compound cpdm,phenotype
R1246 T1484 T1481 pobj phenotype,in
R1247 T1485 T1111 punct .,reveal

UBERON-AE

Id Subject Object Predicate Lexical cue
T946 104-109 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T947 176-183 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
T948 676-682 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organs
T949 2147-2153 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organs

GO-BP

Id Subject Object Predicate Lexical cue
T1993 432-446 http://purl.obolibrary.org/obo/GO_0009299 denotes mRNA synthesis
T1994 437-446 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T1995 642-653 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T1996 758-761 http://purl.obolibrary.org/obo/GO_0007568 denotes age
T1997 1065-1094 http://purl.obolibrary.org/obo/GO_0001806 denotes delayed type hypersensitivity
T1998 1078-1103 http://purl.obolibrary.org/obo/GO_0002524 denotes hypersensitivity response
T1999 1118-1127 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T2000 2321-2330 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T2001 2385-2394 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T2002 1164-1184 http://purl.obolibrary.org/obo/GO_0042088 denotes Th1 immune responses
T2003 1168-1184 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T2004 2182-2198 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T2005 2282-2297 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T2006 1206-1225 http://purl.obolibrary.org/obo/GO_0042092 denotes Th2 immune response
T2007 1206-1225 http://purl.obolibrary.org/obo/GO_0002828 denotes Th2 immune response
T2008 1716-1725 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T2009 1982-1989 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T2010 1791-1801 http://purl.obolibrary.org/obo/GO_0046960 denotes sensitized
T2011 1818-1827 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T2012 1818-1827 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T2013 1832-1842 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T2014 1837-1842 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T2015 2032-2056 http://purl.obolibrary.org/obo/GO_0002820 denotes adaptive immune response
T2016 2032-2056 http://purl.obolibrary.org/obo/GO_0002821 denotes adaptive immune response
T2017 2032-2056 http://purl.obolibrary.org/obo/GO_0002819 denotes adaptive immune response
T2018 2032-2056 http://purl.obolibrary.org/obo/GO_0002250 denotes adaptive immune response
T2019 2097-2116 http://purl.obolibrary.org/obo/GO_0019882 denotes processed antigenic
T2020 2097-2125 http://purl.obolibrary.org/obo/GO_0048002 denotes processed antigenic peptides
T2021 2166-2181 http://purl.obolibrary.org/obo/GO_0001913 denotes T-cell-mediated
T2022 2168-2188 http://purl.obolibrary.org/obo/GO_0002456 denotes cell-mediated immune
T2023 2166-2188 http://purl.obolibrary.org/obo/GO_0002709 denotes T-cell-mediated immune
T2024 2168-2188 http://purl.obolibrary.org/obo/GO_0002449 denotes cell-mediated immune
T2025 2168-2188 http://purl.obolibrary.org/obo/GO_0019724 denotes cell-mediated immune
T2026 2168-2188 http://purl.obolibrary.org/obo/GO_0002228 denotes cell-mediated immune
T2027 2168-2198 http://purl.obolibrary.org/obo/GO_0002443 denotes cell-mediated immune responses
T2028 2168-2188 http://purl.obolibrary.org/obo/GO_0001909 denotes cell-mediated immune
T2029 2321-2343 http://purl.obolibrary.org/obo/GO_0050663 denotes secretion of cytokines
T2030 2376-2394 http://purl.obolibrary.org/obo/GO_0050663 denotes cytokine secretion
T2031 2621-2637 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T2032 2705-2724 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production

GO-MF

Id Subject Object Predicate Lexical cue
T2038 1355-1363 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T2039 1631-1640 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T2040 2643-2649 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand

GO-CC

Id Subject Object Predicate Lexical cue
T2041 50-73 http://purl.obolibrary.org/obo/GO_0014069 denotes post-synaptic densities
T2042 77-96 http://purl.obolibrary.org/obo/GO_0060076 denotes excitatory synapses
T2043 88-96 http://purl.obolibrary.org/obo/GO_0045202 denotes synapses
T2044 1355-1363 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T2045 1355-1363 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T2046 1656-1670 http://purl.obolibrary.org/obo/GO_0071797 denotes complex (LUBAC
T2047 1832-1836 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2048 2168-2172 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2049 2253-2258 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2050 2746-2751 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T978 13-188 Sentence denotes SHARPIN was originally identified in post-synaptic densities of excitatory synapses in the brain of rats [1], but this protein is widely expressed in a variety of tissues [2].
T979 189-495 Sentence denotes Two allelic, autosomal recessive mutations in the Sharpin gene occurred spontaneously in two inbred strains of mice, C57B/KaLawRij-Sharpincpdm/Sharpincpdm and CBy.Ocb3/Dem-Sharpincpdm-Dem/Sharpincpdm-Dem, resulting in premature termination of mRNA synthesis and absence of a functional protein product [2].
T980 496-691 Sentence denotes Despite different genetic backgrounds, both mutations cause similar inflammatory disease with severe chronic progressive dermatitis and defective development of secondary lymphoid organs [2]–[4].
T981 692-762 Sentence denotes The dermatitis becomes clinically apparent at about four weeks of age.
T982 763-1038 Sentence denotes There are accumulations of eosinophils, neutrophils and macrophages in the skin of Sharpincpdm/Sharpincpdm mutant mice (hereafter referred to as cpdm mice) associated with increased expression of Th2 cytokines in the skin and in the supernatants of activated splenocytes [5].
T983 1039-1226 Sentence denotes The mice have an impaired delayed type hypersensitivity response and decreased secretion of IFNγ [5], indicating a defect in Th1 immune responses and a bias towards a Th2 immune response.
T984 1227-1329 Sentence denotes Systemic treatment of cpdm mice with recombinant IL12 caused complete remission of the dermatitis [5].
T985 1330-1536 Sentence denotes Neutralization of IL5 by antibody treatment or crosses with IL5-deficient mice reduced the number of circulating and cutaneous eosinophils, but failed to reduce the onset and severity of the dermatitis [6].
T986 1537-1734 Sentence denotes Recently, three independent groups identified SHARPIN as an essential component of the linear ubiquitin chain assembly complex (LUBAC) that regulates TNFα-induced canonical NF-κB signaling [7]–[9].
T987 1735-1909 Sentence denotes SHARPIN-deficient mouse embryonic fibroblast (MEF) were sensitized to TNFα-induced apoptosis and cell death was implicated as a factor in the dermatitis of cpdm mice [7]–[9].
T988 1910-2062 Sentence denotes Dendritic cells (DC) have a sentinel role in sensing pathogen or danger signals and initiate and direct activation of the adaptive immune response [10].
T989 2063-2212 Sentence denotes Activated and mature DC can carry processed antigenic peptides, migrate to lymphoid organs, and induce T-cell-mediated immune responses or tolerance.
T990 2213-2344 Sentence denotes DC direct the differentiation of CD4+ T cells, and hence the type of immune response, through the selective secretion of cytokines.
T991 2345-2480 Sentence denotes We hypothesized that defective cytokine secretion by DC contributed to the Th2-biased inflammatory phenotype in SHARPIN-deficient mice.
T992 2481-2662 Sentence denotes The studies reported here found that lack of SHARPIN protein in BMDC caused defective expression of pro-inflammatory mediators and impaired NF-κB activation upon ligand stimulation.
T993 2663-2768 Sentence denotes The ability of cpdm BMDC to stimulate Th1 cytokine production in allogeneic CD4+ T cells was compromised.
T994 2769-2966 Sentence denotes Taken together, these results reveal that SHARPIN is a novel regulatory molecule in DC biology and suggest that the dysregulated function of SHARPIN-deficient DC plays a role in the cpdm phenotype.
T13 0-12 Sentence denotes Introduction
T14 13-188 Sentence denotes SHARPIN was originally identified in post-synaptic densities of excitatory synapses in the brain of rats [1], but this protein is widely expressed in a variety of tissues [2].
T15 189-495 Sentence denotes Two allelic, autosomal recessive mutations in the Sharpin gene occurred spontaneously in two inbred strains of mice, C57B/KaLawRij-Sharpincpdm/Sharpincpdm and CBy.Ocb3/Dem-Sharpincpdm-Dem/Sharpincpdm-Dem, resulting in premature termination of mRNA synthesis and absence of a functional protein product [2].
T16 496-691 Sentence denotes Despite different genetic backgrounds, both mutations cause similar inflammatory disease with severe chronic progressive dermatitis and defective development of secondary lymphoid organs [2]–[4].
T17 692-762 Sentence denotes The dermatitis becomes clinically apparent at about four weeks of age.
T18 763-1038 Sentence denotes There are accumulations of eosinophils, neutrophils and macrophages in the skin of Sharpincpdm/Sharpincpdm mutant mice (hereafter referred to as cpdm mice) associated with increased expression of Th2 cytokines in the skin and in the supernatants of activated splenocytes [5].
T19 1039-1226 Sentence denotes The mice have an impaired delayed type hypersensitivity response and decreased secretion of IFNγ [5], indicating a defect in Th1 immune responses and a bias towards a Th2 immune response.
T20 1227-1329 Sentence denotes Systemic treatment of cpdm mice with recombinant IL12 caused complete remission of the dermatitis [5].
T21 1330-1536 Sentence denotes Neutralization of IL5 by antibody treatment or crosses with IL5-deficient mice reduced the number of circulating and cutaneous eosinophils, but failed to reduce the onset and severity of the dermatitis [6].
T22 1537-1734 Sentence denotes Recently, three independent groups identified SHARPIN as an essential component of the linear ubiquitin chain assembly complex (LUBAC) that regulates TNFα-induced canonical NF-κB signaling [7]–[9].
T23 1735-1909 Sentence denotes SHARPIN-deficient mouse embryonic fibroblast (MEF) were sensitized to TNFα-induced apoptosis and cell death was implicated as a factor in the dermatitis of cpdm mice [7]–[9].
T24 1910-2062 Sentence denotes Dendritic cells (DC) have a sentinel role in sensing pathogen or danger signals and initiate and direct activation of the adaptive immune response [10].
T25 2063-2212 Sentence denotes Activated and mature DC can carry processed antigenic peptides, migrate to lymphoid organs, and induce T-cell-mediated immune responses or tolerance.
T26 2213-2344 Sentence denotes DC direct the differentiation of CD4+ T cells, and hence the type of immune response, through the selective secretion of cytokines.
T27 2345-2480 Sentence denotes We hypothesized that defective cytokine secretion by DC contributed to the Th2-biased inflammatory phenotype in SHARPIN-deficient mice.
T28 2481-2662 Sentence denotes The studies reported here found that lack of SHARPIN protein in BMDC caused defective expression of pro-inflammatory mediators and impaired NF-κB activation upon ligand stimulation.
T29 2663-2768 Sentence denotes The ability of cpdm BMDC to stimulate Th1 cytokine production in allogeneic CD4+ T cells was compromised.
T30 2769-2966 Sentence denotes Taken together, these results reveal that SHARPIN is a novel regulatory molecule in DC biology and suggest that the dysregulated function of SHARPIN-deficient DC plays a role in the cpdm phenotype.

ICD10

Id Subject Object Predicate Lexical cue
T2033 617-627 http://purl.bioontology.org/ontology/ICD10/L30.9 denotes dermatitis
T2034 696-706 http://purl.bioontology.org/ontology/ICD10/L30.9 denotes dermatitis
T2035 1314-1324 http://purl.bioontology.org/ontology/ICD10/L30.9 denotes dermatitis
T2036 1521-1531 http://purl.bioontology.org/ontology/ICD10/L30.9 denotes dermatitis
T2037 1877-1887 http://purl.bioontology.org/ontology/ICD10/L30.9 denotes dermatitis

events-check-again

Id Subject Object Predicate Lexical cue
T2107 13-20 Protein denotes SHARPIN
T2108 150-159 Gene_expression denotes expressed
T2109 212-231 Negative_regulation denotes recessive mutations
T2110 239-246 Protein denotes Sharpin
T2111 394-403 Positive_regulation denotes resulting
T2112 394-403 Positive_regulation denotes resulting
T2113 417-428 Negative_regulation denotes termination
T2114 437-446 Transcription denotes synthesis
T2115 451-458 Negative_regulation denotes absence
T2116 1108-1117 Negative_regulation denotes decreased
T2117 1118-1127 Gene_expression denotes secretion
T2118 1131-1135 Protein denotes IFNγ
T2119 1330-1344 Negative_regulation denotes Neutralization
T2120 1348-1351 Protein denotes IL5
T2121 1390-1393 Protein denotes IL5
T2122 1394-1403 Negative_regulation denotes deficient
T2123 1583-1590 Protein denotes SHARPIN
T2124 1687-1691 Protein denotes TNFα
T2125 1735-1742 Protein denotes SHARPIN
T2126 1743-1752 Negative_regulation denotes deficient
T2127 1805-1809 Protein denotes TNFα
T2128 2457-2464 Protein denotes SHARPIN
T2129 2465-2474 Negative_regulation denotes deficient
T2130 2518-2522 Negative_regulation denotes lack
T2131 2526-2533 Protein denotes SHARPIN
T2132 2811-2818 Protein denotes SHARPIN
T2133 2910-2917 Protein denotes SHARPIN
T2134 2918-2927 Negative_regulation denotes deficient
R1758 T2109 T2112 causeOf recessive mutations,resulting
R1762 T2110 T2115 themeOf Sharpin,absence
R1763 T2110 T2114 themeOf Sharpin,synthesis
R1767 T2115 T2112 themeOf absence,resulting
R1768 T2120 T2119 themeOf IL5,Neutralization
R1769 T2117 T2116 themeOf secretion,decreased
R1770 T2121 T2122 themeOf IL5,deficient
R1771 T2118 T2117 themeOf IFNγ,secretion
R1772 T2125 T2126 themeOf SHARPIN,deficient
R1774 T2128 T2129 themeOf SHARPIN,deficient
R1775 T2131 T2130 themeOf SHARPIN,lack
R1757 T2107 T2108 themeOf SHARPIN,expressed
R1761 T2109 T2111 causeOf recessive mutations,resulting
R1764 T2110 T2109 themeOf Sharpin,recessive mutations
R1765 T2113 T2111 themeOf termination,resulting
R1766 T2114 T2113 themeOf synthesis,termination
R1777 T2133 T2134 themeOf SHARPIN,deficient

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T2139 1164-1167 Protein denotes Th1
T2140 1118-1127 Localization denotes secretion
T2141 1108-1117 Negative_regulation denotes decreased
T2142 1276-1280 Protein denotes IL12
T2143 1348-1351 Protein denotes IL5
T2144 1390-1393 Protein denotes IL5
T2145 1394-1403 Negative_regulation denotes deficient
T2146 1583-1590 Protein denotes SHARPIN
T2147 1687-1691 Protein denotes TNFα
T2148 1710-1715 Protein denotes NF-κB
T2149 1735-1742 Protein denotes SHARPIN
T2150 1805-1809 Protein denotes TNFα
T2151 1743-1752 Negative_regulation denotes deficient
T2152 2246-2250 Protein denotes CD4+
T2153 2457-2464 Protein denotes SHARPIN
T2154 2465-2474 Negative_regulation denotes deficient
T2155 2526-2541 Protein denotes SHARPIN protein
T2156 2621-2626 Protein denotes NF-κB
T2157 2518-2522 Negative_regulation denotes lack
T2158 2627-2637 Positive_regulation denotes activation
T2159 2612-2620 Negative_regulation denotes impaired
T2160 2701-2704 Protein denotes Th1
T2161 2714-2724 Gene_expression denotes production
T2162 2691-2700 Positive_regulation denotes stimulate
T2163 2811-2818 Protein denotes SHARPIN
T2164 2910-2917 Protein denotes SHARPIN
T2165 2918-2927 Negative_regulation denotes deficient
T2135 13-20 Protein denotes SHARPIN
T2136 150-159 Gene_expression denotes expressed
T2137 239-251 Protein denotes Sharpin gene
T2138 1131-1139 Protein denotes IFNγ [5]
R1787 T2161 T2162 themeOf production,stimulate
R1788 T2164 T2165 themeOf SHARPIN,deficient
R1773 T2135 T2136 themeOf SHARPIN,expressed
R1776 T2138 T2140 themeOf IFNγ [5],secretion
R1778 T2140 T2141 themeOf secretion,decreased
R1779 T2144 T2145 themeOf IL5,deficient
R1780 T2149 T2151 themeOf SHARPIN,deficient
R1781 T2153 T2154 themeOf SHARPIN,deficient
R1782 T2155 T2157 themeOf SHARPIN protein,lack
R1783 T2156 T2158 themeOf NF-κB,activation
R1784 T2157 T2159 causeOf lack,impaired
R1785 T2158 T2159 themeOf activation,impaired
R1786 T2160 T2161 themeOf Th1,production

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue
T972 2465-2474 Negative_regulation denotes deficient
T973 2518-2522 Negative_regulation denotes lack
T974 2526-2533 Protein denotes SHARPIN
T975 2811-2818 Protein denotes SHARPIN
T976 2910-2917 Protein denotes SHARPIN
T977 2918-2927 Negative_regulation denotes deficient
T950 13-20 Protein denotes SHARPIN
T951 150-159 Gene_expression denotes expressed
T952 212-231 Negative_regulation denotes recessive mutations
T953 239-246 Protein denotes Sharpin
T954 394-403 Positive_regulation denotes resulting
T955 394-403 Positive_regulation denotes resulting
T956 417-428 Negative_regulation denotes termination
T957 437-446 Transcription denotes synthesis
T958 451-458 Negative_regulation denotes absence
T959 1108-1117 Negative_regulation denotes decreased
T960 1118-1127 Gene_expression denotes secretion
T961 1131-1135 Protein denotes IFNγ
T962 1330-1344 Negative_regulation denotes Neutralization
T963 1348-1351 Protein denotes IL5
T964 1390-1393 Protein denotes IL5
T965 1394-1403 Negative_regulation denotes deficient
T966 1583-1590 Protein denotes SHARPIN
T967 1687-1691 Protein denotes TNFα
T968 1735-1742 Protein denotes SHARPIN
T969 1743-1752 Negative_regulation denotes deficient
T970 1805-1809 Protein denotes TNFα
T971 2457-2464 Protein denotes SHARPIN
R746 T956 T954 themeOf termination,resulting
R747 T957 T956 themeOf synthesis,termination
R748 T958 T955 themeOf absence,resulting
R749 T960 T959 themeOf secretion,decreased
R750 T961 T960 themeOf IFNγ,secretion
R751 T963 T962 themeOf IL5,Neutralization
R752 T964 T965 themeOf IL5,deficient
R753 T968 T969 themeOf SHARPIN,deficient
R754 T971 T972 themeOf SHARPIN,deficient
R755 T974 T973 themeOf SHARPIN,lack
R756 T976 T977 themeOf SHARPIN,deficient
R740 T950 T951 themeOf SHARPIN,expressed
R741 T952 T955 causeOf recessive mutations,resulting
R742 T952 T954 causeOf recessive mutations,resulting
R743 T953 T958 themeOf Sharpin,absence
R744 T953 T957 themeOf Sharpin,synthesis
R745 T953 T952 themeOf Sharpin,recessive mutations

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T1964 13-20 Q9H0F6 denotes SHARPIN
T1965 239-246 Q9H0F6 denotes Sharpin
T1966 1348-1351 P05113 denotes IL5
T1967 1390-1393 P05113 denotes IL5
T1968 1583-1590 Q9H0F6 denotes SHARPIN
T1969 1735-1742 Q9H0F6 denotes SHARPIN
T1970 2246-2249 P01730 denotes CD4
T1971 2457-2464 Q9H0F6 denotes SHARPIN
T1972 2526-2533 Q9H0F6 denotes SHARPIN
T1973 2739-2742 P01730 denotes CD4
T1974 2811-2818 Q9H0F6 denotes SHARPIN
T1975 2910-2917 Q9H0F6 denotes SHARPIN

test2

Id Subject Object Predicate Lexical cue
T925 13-20 Protein denotes SHARPIN
T926 239-246 Protein denotes Sharpin
T927 1108-1117 Negative_regulation denotes decreased
T928 1118-1127 Gene_expression denotes secretion
T929 1131-1135 Protein denotes IFNγ
T930 1330-1344 Negative_regulation denotes Neutralization
T931 1348-1351 Protein denotes IL5
T932 1390-1393 Protein denotes IL5
T933 1394-1403 Negative_regulation denotes deficient
T934 1583-1590 Protein denotes SHARPIN
T935 1687-1691 Protein denotes TNFα
T936 1735-1742 Protein denotes SHARPIN
T937 1743-1752 Negative_regulation denotes deficient
T938 1805-1809 Protein denotes TNFα
T939 2457-2464 Protein denotes SHARPIN
T940 2465-2474 Negative_regulation denotes deficient
T941 2518-2522 Negative_regulation denotes lack
T942 2526-2533 Protein denotes SHARPIN
T943 2811-2818 Protein denotes SHARPIN
T944 2910-2917 Protein denotes SHARPIN
T945 2918-2927 Negative_regulation denotes deficient
R732 T928 T927 themeOf secretion,decreased
R733 T929 T928 themeOf IFNγ,secretion
R734 T931 T930 themeOf IL5,Neutralization
R735 T932 T933 themeOf IL5,deficient
R736 T936 T937 themeOf SHARPIN,deficient
R737 T939 T940 themeOf SHARPIN,deficient
R738 T942 T941 themeOf SHARPIN,lack
R739 T944 T945 themeOf SHARPIN,deficient