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Unstained cells serve as negative controls. (B) Cultured WT and cpdm BMDC (1×105 cells in 0.1 ml complete medium) were washed and stimulated with medium, 100 ng/ml LPS or 25 µg/ml poly I:C for 24 hours. Supernatants were collected for ELISA of IL10. (C) Cultured WT and cpdm BMDC (5×105 cells in 0.2 ml complete medium) were washed and stimulated with 100 ng/ml LPS or 25 µg/ml poly I:C. At 0, 1, and 2 hours, total RNA was extracted and subject to qRT-PCR to measure the production of A20. "}

{"project":"GO-BP","denotations":[{"id":"T14904","span":{"begin":94,"end":103},"obj":"http://purl.obolibrary.org/obo/GO_0046903"}],"text":"10.1371/journal.pone.0031809.g005 Figure 5 Normal TLR4 and MD2 expression and decreased IL10 secretion and A20 expression by cpdm BMDC.\n(A) Unstimulated WT and cpdm BMDC (5×105) were labeled with PE-labeled anti-TLR4/MD2 or anti-CD14 and then subject to flow cytometry analysis. Unstained cells serve as negative controls. (B) Cultured WT and cpdm BMDC (1×105 cells in 0.1 ml complete medium) were washed and stimulated with medium, 100 ng/ml LPS or 25 µg/ml poly I:C for 24 hours. Supernatants were collected for ELISA of IL10. (C) Cultured WT and cpdm BMDC (5×105 cells in 0.2 ml complete medium) were washed and stimulated with 100 ng/ml LPS or 25 µg/ml poly I:C. At 0, 1, and 2 hours, total RNA was extracted and subject to qRT-PCR to measure the production of A20. "}

{"project":"GO-CC","denotations":[{"id":"T14905","span":{"begin":290,"end":295},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T14906","span":{"begin":361,"end":366},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T14907","span":{"begin":567,"end":572},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"10.1371/journal.pone.0031809.g005 Figure 5 Normal TLR4 and MD2 expression and decreased IL10 secretion and A20 expression by cpdm BMDC.\n(A) Unstimulated WT and cpdm BMDC (5×105) were labeled with PE-labeled anti-TLR4/MD2 or anti-CD14 and then subject to flow cytometry analysis. Unstained cells serve as negative controls. (B) Cultured WT and cpdm BMDC (1×105 cells in 0.1 ml complete medium) were washed and stimulated with medium, 100 ng/ml LPS or 25 µg/ml poly I:C for 24 hours. Supernatants were collected for ELISA of IL10. (C) Cultured WT and cpdm BMDC (5×105 cells in 0.2 ml complete medium) were washed and stimulated with 100 ng/ml LPS or 25 µg/ml poly I:C. At 0, 1, and 2 hours, total RNA was extracted and subject to qRT-PCR to measure the production of A20. "}

{"project":"sentences","denotations":[{"id":"T14580","span":{"begin":44,"end":136},"obj":"Sentence"},{"id":"T14581","span":{"begin":137,"end":279},"obj":"Sentence"},{"id":"T14582","span":{"begin":280,"end":482},"obj":"Sentence"},{"id":"T14583","span":{"begin":483,"end":770},"obj":"Sentence"},{"id":"T97","span":{"begin":0,"end":136},"obj":"Sentence"},{"id":"T98","span":{"begin":137,"end":279},"obj":"Sentence"},{"id":"T99","span":{"begin":280,"end":482},"obj":"Sentence"},{"id":"T100","span":{"begin":483,"end":667},"obj":"Sentence"},{"id":"T101","span":{"begin":668,"end":770},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"10.1371/journal.pone.0031809.g005 Figure 5 Normal TLR4 and MD2 expression and decreased IL10 secretion and A20 expression by cpdm BMDC.\n(A) Unstimulated WT and cpdm BMDC (5×105) were labeled with PE-labeled anti-TLR4/MD2 or anti-CD14 and then subject to flow cytometry analysis. Unstained cells serve as negative controls. (B) Cultured WT and cpdm BMDC (1×105 cells in 0.1 ml complete medium) were washed and stimulated with medium, 100 ng/ml LPS or 25 µg/ml poly I:C for 24 hours. Supernatants were collected for ELISA of IL10. (C) Cultured WT and cpdm BMDC (5×105 cells in 0.2 ml complete medium) were washed and stimulated with 100 ng/ml LPS or 25 µg/ml poly I:C. At 0, 1, and 2 hours, total RNA was extracted and subject to qRT-PCR to measure the production of A20. "}

{"project":"events-check-again","denotations":[{"id":"T14938","span":{"begin":44,"end":50},"obj":"Negative_regulation"},{"id":"T14939","span":{"begin":44,"end":50},"obj":"Negative_regulation"},{"id":"T14940","span":{"begin":51,"end":55},"obj":"Protein"},{"id":"T14941","span":{"begin":60,"end":63},"obj":"Protein"},{"id":"T14942","span":{"begin":64,"end":74},"obj":"Gene_expression"},{"id":"T14943","span":{"begin":64,"end":74},"obj":"Gene_expression"},{"id":"T14944","span":{"begin":79,"end":88},"obj":"Negative_regulation"},{"id":"T14945","span":{"begin":79,"end":88},"obj":"Negative_regulation"},{"id":"T14946","span":{"begin":89,"end":93},"obj":"Protein"},{"id":"T14947","span":{"begin":94,"end":103},"obj":"Gene_expression"},{"id":"T14948","span":{"begin":108,"end":111},"obj":"Protein"},{"id":"T14949","span":{"begin":112,"end":122},"obj":"Gene_expression"},{"id":"T14950","span":{"begin":524,"end":528},"obj":"Protein"},{"id":"T14951","span":{"begin":752,"end":762},"obj":"Gene_expression"},{"id":"T14952","span":{"begin":766,"end":769},"obj":"Protein"}],"relations":[{"id":"R12521","pred":"themeOf","subj":"T14940","obj":"T14943"},{"id":"R12522","pred":"themeOf","subj":"T14941","obj":"T14942"},{"id":"R12523","pred":"themeOf","subj":"T14942","obj":"T14939"},{"id":"R12524","pred":"themeOf","subj":"T14943","obj":"T14938"},{"id":"R12525","pred":"themeOf","subj":"T14946","obj":"T14947"},{"id":"R12526","pred":"themeOf","subj":"T14947","obj":"T14944"},{"id":"R12527","pred":"themeOf","subj":"T14948","obj":"T14949"},{"id":"R12528","pred":"themeOf","subj":"T14949","obj":"T14945"},{"id":"R12529","pred":"themeOf","subj":"T14952","obj":"T14951"}],"attributes":[{"id":"M191","pred":"Negation","subj":"T14939","obj":"true"},{"id":"M192","pred":"Speculation","subj":"T14951","obj":"true"},{"id":"M190","pred":"Negation","subj":"T14938","obj":"true"}],"text":"10.1371/journal.pone.0031809.g005 Figure 5 Normal TLR4 and MD2 expression and decreased IL10 secretion and A20 expression by cpdm BMDC.\n(A) Unstimulated WT and cpdm BMDC (5×105) were labeled with PE-labeled anti-TLR4/MD2 or anti-CD14 and then subject to flow cytometry analysis. Unstained cells serve as negative controls. (B) Cultured WT and cpdm BMDC (1×105 cells in 0.1 ml complete medium) were washed and stimulated with medium, 100 ng/ml LPS or 25 µg/ml poly I:C for 24 hours. Supernatants were collected for ELISA of IL10. (C) Cultured WT and cpdm BMDC (5×105 cells in 0.2 ml complete medium) were washed and stimulated with 100 ng/ml LPS or 25 µg/ml poly I:C. At 0, 1, and 2 hours, total RNA was extracted and subject to qRT-PCR to measure the production of A20. "}

{"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T14953","span":{"begin":51,"end":55},"obj":"Protein"},{"id":"T14954","span":{"begin":60,"end":63},"obj":"Protein"},{"id":"T14955","span":{"begin":89,"end":93},"obj":"Protein"},{"id":"T14956","span":{"begin":64,"end":74},"obj":"Gene_expression"},{"id":"T14957","span":{"begin":64,"end":74},"obj":"Gene_expression"},{"id":"T14958","span":{"begin":79,"end":88},"obj":"Negative_regulation"},{"id":"T14959","span":{"begin":79,"end":88},"obj":"Negative_regulation"},{"id":"T14960","span":{"begin":94,"end":103},"obj":"Localization"},{"id":"T14961","span":{"begin":79,"end":88},"obj":"Negative_regulation"},{"id":"T14962","span":{"begin":213,"end":217},"obj":"Protein"},{"id":"T14963","span":{"begin":218,"end":221},"obj":"Protein"},{"id":"T14964","span":{"begin":230,"end":234},"obj":"Protein"},{"id":"T14965","span":{"begin":524,"end":528},"obj":"Protein"},{"id":"T14966","span":{"begin":729,"end":732},"obj":"Protein"},{"id":"T14967","span":{"begin":766,"end":769},"obj":"Protein"},{"id":"T14968","span":{"begin":752,"end":762},"obj":"Gene_expression"}],"relations":[{"id":"R12530","pred":"themeOf","subj":"T14953","obj":"T14956"},{"id":"R12531","pred":"themeOf","subj":"T14954","obj":"T14957"},{"id":"R12532","pred":"themeOf","subj":"T14955","obj":"T14960"},{"id":"R12533","pred":"themeOf","subj":"T14956","obj":"T14958"},{"id":"R12534","pred":"themeOf","subj":"T14957","obj":"T14959"},{"id":"R12535","pred":"themeOf","subj":"T14960","obj":"T14961"},{"id":"R12536","pred":"themeOf","subj":"T14967","obj":"T14968"}],"text":"10.1371/journal.pone.0031809.g005 Figure 5 Normal TLR4 and MD2 expression and decreased IL10 secretion and A20 expression by cpdm BMDC.\n(A) Unstimulated WT and cpdm BMDC (5×105) were labeled with PE-labeled anti-TLR4/MD2 or anti-CD14 and then subject to flow cytometry analysis. Unstained cells serve as negative controls. (B) Cultured WT and cpdm BMDC (1×105 cells in 0.1 ml complete medium) were washed and stimulated with medium, 100 ng/ml LPS or 25 µg/ml poly I:C for 24 hours. Supernatants were collected for ELISA of IL10. (C) Cultured WT and cpdm BMDC (5×105 cells in 0.2 ml complete medium) were washed and stimulated with 100 ng/ml LPS or 25 µg/ml poly I:C. At 0, 1, and 2 hours, total RNA was extracted and subject to qRT-PCR to measure the production of A20. "}

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{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T14853","span":{"begin":51,"end":55},"obj":"O00206"},{"id":"T14854","span":{"begin":89,"end":93},"obj":"P22301"},{"id":"T14855","span":{"begin":108,"end":111},"obj":"P21580"},{"id":"T14856","span":{"begin":213,"end":217},"obj":"O00206"},{"id":"T14857","span":{"begin":230,"end":234},"obj":"P08571"},{"id":"T14858","span":{"begin":524,"end":528},"obj":"P22301"},{"id":"T14859","span":{"begin":766,"end":769},"obj":"P21580"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"10.1371/journal.pone.0031809.g005 Figure 5 Normal TLR4 and MD2 expression and decreased IL10 secretion and A20 expression by cpdm BMDC.\n(A) Unstimulated WT and cpdm BMDC (5×105) were labeled with PE-labeled anti-TLR4/MD2 or anti-CD14 and then subject to flow cytometry analysis. Unstained cells serve as negative controls. (B) Cultured WT and cpdm BMDC (1×105 cells in 0.1 ml complete medium) were washed and stimulated with medium, 100 ng/ml LPS or 25 µg/ml poly I:C for 24 hours. Supernatants were collected for ELISA of IL10. (C) Cultured WT and cpdm BMDC (5×105 cells in 0.2 ml complete medium) were washed and stimulated with 100 ng/ml LPS or 25 µg/ml poly I:C. At 0, 1, and 2 hours, total RNA was extracted and subject to qRT-PCR to measure the production of A20. "}

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