PMC:3279418 / 1357-1653
Annnotations
pmc-enju-pas
{"project":"pmc-enju-pas","denotations":[{"id":"T605","span":{"begin":0,"end":1},"obj":"-RRB-"},{"id":"T606","span":{"begin":2,"end":5},"obj":"CC"},{"id":"T607","span":{"begin":6,"end":10},"obj":"NN"},{"id":"T608","span":{"begin":11,"end":20},"obj":"NN"},{"id":"T609","span":{"begin":21,"end":29},"obj":"NN"},{"id":"T610","span":{"begin":30,"end":34},"obj":"VB"},{"id":"T611","span":{"begin":35,"end":41},"obj":"JJ"},{"id":"T612","span":{"begin":43,"end":44},"obj":"DT"},{"id":"T613","span":{"begin":45,"end":50},"obj":"JJ"},{"id":"T614","span":{"begin":51,"end":61},"obj":"NN"},{"id":"T615","span":{"begin":62,"end":70},"obj":"NN"},{"id":"T616","span":{"begin":71,"end":77},"obj":"VB"},{"id":"T617","span":{"begin":78,"end":82},"obj":"IN"},{"id":"T618","span":{"begin":83,"end":89},"obj":"JJ"},{"id":"T619","span":{"begin":90,"end":94},"obj":"NN"},{"id":"T620","span":{"begin":95,"end":99},"obj":"RB"},{"id":"T621","span":{"begin":100,"end":107},"obj":"VB"},{"id":"T622","span":{"begin":108,"end":109},"obj":"DT"},{"id":"T623","span":{"begin":110,"end":114},"obj":"JJ"},{"id":"T624","span":{"begin":115,"end":118},"obj":"NN"},{"id":"T625","span":{"begin":119,"end":125},"obj":"JJ"},{"id":"T626","span":{"begin":126,"end":134},"obj":"NN"},{"id":"T627","span":{"begin":135,"end":138},"obj":"CC"},{"id":"T628","span":{"begin":139,"end":149},"obj":"VB"},{"id":"T629","span":{"begin":150,"end":159},"obj":"VB"},{"id":"T630","span":{"begin":160,"end":163},"obj":"NN"},{"id":"T631","span":{"begin":164,"end":172},"obj":"NN"},{"id":"T632","span":{"begin":173,"end":183},"obj":"NN"},{"id":"T633","span":{"begin":184,"end":188},"obj":"IN"},{"id":"T634","span":{"begin":189,"end":199},"obj":"JJ"},{"id":"T635","span":{"begin":200,"end":205},"obj":"NN"},{"id":"T636","span":{"begin":206,"end":210},"obj":"JJ"},{"id":"T637","span":{"begin":211,"end":212},"obj":"NN"},{"id":"T638","span":{"begin":213,"end":218},"obj":"NN"},{"id":"T639","span":{"begin":220,"end":222},"obj":"IN"},{"id":"T640","span":{"begin":223,"end":233},"obj":"NN"},{"id":"T641","span":{"begin":233,"end":234},"obj":"-COMMA-"},{"id":"T642","span":{"begin":235,"end":239},"obj":"NN"},{"id":"T643","span":{"begin":240,"end":242},"obj":"IN"},{"id":"T644","span":{"begin":243,"end":250},"obj":"NN"},{"id":"T645","span":{"begin":251,"end":253},"obj":"IN"},{"id":"T646","span":{"begin":254,"end":258},"obj":"NN"},{"id":"T647","span":{"begin":259,"end":272},"obj":"RB"},{"id":"T648","span":{"begin":273,"end":280},"obj":"VB"},{"id":"T649","span":{"begin":281,"end":284},"obj":"DT"},{"id":"T650","span":{"begin":285,"end":291},"obj":"JJ"}],"relations":[{"id":"R525","pred":"arg2Of","subj":"T609","obj":"T606"},{"id":"R526","pred":"arg1Of","subj":"T609","obj":"T607"},{"id":"R527","pred":"arg1Of","subj":"T609","obj":"T608"},{"id":"R529","pred":"arg2Of","subj":"T611","obj":"T610"},{"id":"R530","pred":"arg1Of","subj":"T615","obj":"T612"},{"id":"R531","pred":"arg1Of","subj":"T615","obj":"T613"},{"id":"R532","pred":"arg1Of","subj":"T615","obj":"T614"},{"id":"R533","pred":"arg1Of","subj":"T615","obj":"T616"},{"id":"R534","pred":"arg1Of","subj":"T619","obj":"T618"},{"id":"R535","pred":"arg1Of","subj":"T619","obj":"T621"},{"id":"R536","pred":"arg1Of","subj":"T619","obj":"T628"},{"id":"R537","pred":"arg1Of","subj":"T621","obj":"T627"},{"id":"R538","pred":"arg2Of","subj":"T626","obj":"T621"},{"id":"R539","pred":"arg1Of","subj":"T626","obj":"T622"},{"id":"R540","pred":"arg1Of","subj":"T626","obj":"T623"},{"id":"R541","pred":"arg1Of","subj":"T626","obj":"T624"},{"id":"R542","pred":"arg1Of","subj":"T626","obj":"T625"},{"id":"R543","pred":"arg2Of","subj":"T627","obj":"T616"},{"id":"R544","pred":"arg1Of","subj":"T627","obj":"T617"},{"id":"R545","pred":"arg1Of","subj":"T627","obj":"T620"},{"id":"R546","pred":"arg2Of","subj":"T628","obj":"T627"},{"id":"R547","pred":"arg1Of","subj":"T628","obj":"T633"},{"id":"R548","pred":"arg2Of","subj":"T632","obj":"T628"},{"id":"R549","pred":"arg2Of","subj":"T632","obj":"T629"},{"id":"R550","pred":"arg1Of","subj":"T632","obj":"T630"},{"id":"R551","pred":"arg1Of","subj":"T632","obj":"T631"},{"id":"R552","pred":"arg2Of","subj":"T638","obj":"T633"},{"id":"R553","pred":"arg1Of","subj":"T638","obj":"T634"},{"id":"R554","pred":"arg1Of","subj":"T638","obj":"T635"},{"id":"R555","pred":"arg1Of","subj":"T638","obj":"T636"},{"id":"R556","pred":"arg1Of","subj":"T638","obj":"T637"},{"id":"R557","pred":"arg2Of","subj":"T640","obj":"T639"},{"id":"R558","pred":"arg1Of","subj":"T642","obj":"T643"},{"id":"R559","pred":"arg1Of","subj":"T642","obj":"T645"},{"id":"R560","pred":"arg1Of","subj":"T642","obj":"T648"},{"id":"R561","pred":"arg2Of","subj":"T644","obj":"T643"},{"id":"R562","pred":"arg2Of","subj":"T646","obj":"T645"},{"id":"R563","pred":"arg1Of","subj":"T648","obj":"T647"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":") and TBK1 signaling pathways were intact. A mixed lymphocyte reaction showed that mutant BMDC only induced a weak Th1 immune response but stimulated increased Th2 cytokine production from allogeneic naïve CD4+ T cells. In conclusion, loss of Sharpin in mice significantly affects the immune func"}
bionlp-st-ge-2016-spacy-parsed
{"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T333","span":{"begin":0,"end":1},"obj":"-RRB-"},{"id":"T334","span":{"begin":2,"end":5},"obj":"CC"},{"id":"T335","span":{"begin":6,"end":10},"obj":"CD"},{"id":"T336","span":{"begin":11,"end":20},"obj":"VBG"},{"id":"T337","span":{"begin":21,"end":29},"obj":"NNS"},{"id":"T338","span":{"begin":30,"end":34},"obj":"VBD"},{"id":"T339","span":{"begin":35,"end":41},"obj":"JJ"},{"id":"T340","span":{"begin":41,"end":42},"obj":"."},{"id":"T341","span":{"begin":43,"end":44},"obj":"DT"},{"id":"T342","span":{"begin":45,"end":50},"obj":"JJ"},{"id":"T343","span":{"begin":51,"end":61},"obj":"NN"},{"id":"T344","span":{"begin":62,"end":70},"obj":"NN"},{"id":"T345","span":{"begin":71,"end":77},"obj":"VBD"},{"id":"T346","span":{"begin":78,"end":82},"obj":"IN"},{"id":"T347","span":{"begin":83,"end":89},"obj":"JJ"},{"id":"T348","span":{"begin":90,"end":94},"obj":"NNP"},{"id":"T349","span":{"begin":95,"end":99},"obj":"RB"},{"id":"T350","span":{"begin":100,"end":107},"obj":"VBD"},{"id":"T351","span":{"begin":108,"end":109},"obj":"DT"},{"id":"T352","span":{"begin":110,"end":114},"obj":"JJ"},{"id":"T353","span":{"begin":115,"end":118},"obj":"CD"},{"id":"T354","span":{"begin":119,"end":125},"obj":"JJ"},{"id":"T355","span":{"begin":126,"end":134},"obj":"NN"},{"id":"T356","span":{"begin":135,"end":138},"obj":"CC"},{"id":"T357","span":{"begin":139,"end":149},"obj":"VBD"},{"id":"T358","span":{"begin":150,"end":159},"obj":"VBN"},{"id":"T359","span":{"begin":160,"end":163},"obj":"JJ"},{"id":"T360","span":{"begin":164,"end":172},"obj":"NN"},{"id":"T361","span":{"begin":173,"end":183},"obj":"NN"},{"id":"T362","span":{"begin":184,"end":188},"obj":"IN"},{"id":"T363","span":{"begin":189,"end":199},"obj":"JJ"},{"id":"T364","span":{"begin":200,"end":205},"obj":"NN"},{"id":"T365","span":{"begin":206,"end":209},"obj":"NNP"},{"id":"T366","span":{"begin":209,"end":210},"obj":"NNP"},{"id":"T367","span":{"begin":211,"end":212},"obj":"NNP"},{"id":"T368","span":{"begin":213,"end":218},"obj":"NNS"},{"id":"T369","span":{"begin":218,"end":219},"obj":"."},{"id":"T370","span":{"begin":220,"end":222},"obj":"IN"},{"id":"T371","span":{"begin":223,"end":233},"obj":"NN"},{"id":"T372","span":{"begin":233,"end":234},"obj":","},{"id":"T373","span":{"begin":235,"end":239},"obj":"NN"},{"id":"T374","span":{"begin":240,"end":242},"obj":"IN"},{"id":"T375","span":{"begin":243,"end":250},"obj":"NNP"},{"id":"T376","span":{"begin":251,"end":253},"obj":"IN"},{"id":"T377","span":{"begin":254,"end":258},"obj":"NNS"},{"id":"T378","span":{"begin":259,"end":272},"obj":"RB"},{"id":"T379","span":{"begin":273,"end":280},"obj":"VBZ"},{"id":"T380","span":{"begin":281,"end":284},"obj":"DT"},{"id":"T381","span":{"begin":285,"end":291},"obj":"JJ"}],"relations":[{"id":"R251","pred":"nummod","subj":"T335","obj":"T337"},{"id":"R252","pred":"compound","subj":"T336","obj":"T337"},{"id":"R255","pred":"acomp","subj":"T339","obj":"T338"},{"id":"R257","pred":"det","subj":"T341","obj":"T344"},{"id":"R258","pred":"amod","subj":"T342","obj":"T344"},{"id":"R259","pred":"compound","subj":"T343","obj":"T344"},{"id":"R260","pred":"nsubj","subj":"T344","obj":"T345"},{"id":"R261","pred":"ROOT","subj":"T345","obj":"T345"},{"id":"R262","pred":"mark","subj":"T346","obj":"T350"},{"id":"R263","pred":"compound","subj":"T347","obj":"T348"},{"id":"R264","pred":"nsubj","subj":"T348","obj":"T350"},{"id":"R265","pred":"advmod","subj":"T349","obj":"T350"},{"id":"R266","pred":"ccomp","subj":"T350","obj":"T345"},{"id":"R267","pred":"det","subj":"T351","obj":"T355"},{"id":"R268","pred":"amod","subj":"T352","obj":"T355"},{"id":"R269","pred":"nummod","subj":"T353","obj":"T355"},{"id":"R270","pred":"amod","subj":"T354","obj":"T355"},{"id":"R271","pred":"dobj","subj":"T355","obj":"T350"},{"id":"R272","pred":"cc","subj":"T356","obj":"T350"},{"id":"R273","pred":"conj","subj":"T357","obj":"T350"},{"id":"R274","pred":"amod","subj":"T358","obj":"T361"},{"id":"R275","pred":"amod","subj":"T359","obj":"T361"},{"id":"R276","pred":"compound","subj":"T360","obj":"T361"},{"id":"R277","pred":"dobj","subj":"T361","obj":"T357"},{"id":"R278","pred":"prep","subj":"T362","obj":"T361"},{"id":"R279","pred":"amod","subj":"T363","obj":"T364"},{"id":"R280","pred":"amod","subj":"T364","obj":"T368"},{"id":"R281","pred":"compound","subj":"T365","obj":"T368"},{"id":"R282","pred":"compound","subj":"T366","obj":"T368"},{"id":"R283","pred":"compound","subj":"T367","obj":"T368"},{"id":"R284","pred":"pobj","subj":"T368","obj":"T362"},{"id":"R285","pred":"punct","subj":"T369","obj":"T345"},{"id":"R286","pred":"prep","subj":"T370","obj":"T379"},{"id":"R287","pred":"pobj","subj":"T371","obj":"T370"},{"id":"R288","pred":"punct","subj":"T372","obj":"T379"},{"id":"R289","pred":"nsubj","subj":"T373","obj":"T379"},{"id":"R290","pred":"prep","subj":"T374","obj":"T373"},{"id":"R291","pred":"pobj","subj":"T375","obj":"T374"},{"id":"R292","pred":"prep","subj":"T376","obj":"T373"},{"id":"R293","pred":"pobj","subj":"T377","obj":"T376"},{"id":"R294","pred":"advmod","subj":"T378","obj":"T379"},{"id":"R295","pred":"ROOT","subj":"T379","obj":"T379"}],"text":") and TBK1 signaling pathways were intact. A mixed lymphocyte reaction showed that mutant BMDC only induced a weak Th1 immune response but stimulated increased Th2 cytokine production from allogeneic naïve CD4+ T cells. In conclusion, loss of Sharpin in mice significantly affects the immune func"}
GO-BP
{"project":"GO-BP","denotations":[{"id":"T700","span":{"begin":164,"end":183},"obj":"http://purl.obolibrary.org/obo/GO_0001816"},{"id":"T711","span":{"begin":11,"end":20},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T714","span":{"begin":6,"end":10},"obj":"http://purl.obolibrary.org/obo/GO_0008384"},{"id":"T715","span":{"begin":11,"end":29},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T716","span":{"begin":115,"end":134},"obj":"http://purl.obolibrary.org/obo/GO_0042088"},{"id":"T717","span":{"begin":119,"end":134},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T719","span":{"begin":119,"end":149},"obj":"http://purl.obolibrary.org/obo/GO_0002922"},{"id":"T720","span":{"begin":119,"end":149},"obj":"http://purl.obolibrary.org/obo/GO_0045089"},{"id":"T721","span":{"begin":119,"end":149},"obj":"http://purl.obolibrary.org/obo/GO_0050778"},{"id":"T722","span":{"begin":119,"end":149},"obj":"http://purl.obolibrary.org/obo/GO_0002821"}],"text":") and TBK1 signaling pathways were intact. A mixed lymphocyte reaction showed that mutant BMDC only induced a weak Th1 immune response but stimulated increased Th2 cytokine production from allogeneic naïve CD4+ T cells. In conclusion, loss of Sharpin in mice significantly affects the immune func"}
GO-MF
{"project":"GO-MF","denotations":[{"id":"T726","span":{"begin":6,"end":10},"obj":"http://purl.obolibrary.org/obo/GO_0008384"}],"text":") and TBK1 signaling pathways were intact. A mixed lymphocyte reaction showed that mutant BMDC only induced a weak Th1 immune response but stimulated increased Th2 cytokine production from allogeneic naïve CD4+ T cells. In conclusion, loss of Sharpin in mice significantly affects the immune func"}
GO-CC
{"project":"GO-CC","denotations":[{"id":"T729","span":{"begin":213,"end":218},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":") and TBK1 signaling pathways were intact. A mixed lymphocyte reaction showed that mutant BMDC only induced a weak Th1 immune response but stimulated increased Th2 cytokine production from allogeneic naïve CD4+ T cells. In conclusion, loss of Sharpin in mice significantly affects the immune func"}
sentences
{"project":"sentences","denotations":[{"id":"T116","span":{"begin":43,"end":219},"obj":"Sentence"},{"id":"T11","span":{"begin":43,"end":219},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":") and TBK1 signaling pathways were intact. A mixed lymphocyte reaction showed that mutant BMDC only induced a weak Th1 immune response but stimulated increased Th2 cytokine production from allogeneic naïve CD4+ T cells. In conclusion, loss of Sharpin in mice significantly affects the immune func"}
events-check-again
{"project":"events-check-again","denotations":[{"id":"T835","span":{"begin":6,"end":10},"obj":"Protein"},{"id":"T836","span":{"begin":235,"end":239},"obj":"Negative_regulation"},{"id":"T837","span":{"begin":243,"end":250},"obj":"Protein"}],"relations":[{"id":"R629","pred":"themeOf","subj":"T837","obj":"T836"}],"text":") and TBK1 signaling pathways were intact. A mixed lymphocyte reaction showed that mutant BMDC only induced a weak Th1 immune response but stimulated increased Th2 cytokine production from allogeneic naïve CD4+ T cells. In conclusion, loss of Sharpin in mice significantly affects the immune func"}
bionlp-st-ge-2016-reference-tees
{"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T892","span":{"begin":6,"end":10},"obj":"Protein"},{"id":"T894","span":{"begin":206,"end":210},"obj":"Protein"},{"id":"T895","span":{"begin":243,"end":250},"obj":"Protein"},{"id":"T896","span":{"begin":235,"end":239},"obj":"Negative_regulation"}],"relations":[{"id":"R661","pred":"themeOf","subj":"T895","obj":"T896"}],"text":") and TBK1 signaling pathways were intact. A mixed lymphocyte reaction showed that mutant BMDC only induced a weak Th1 immune response but stimulated increased Th2 cytokine production from allogeneic naïve CD4+ T cells. In conclusion, loss of Sharpin in mice significantly affects the immune func"}
bionlp-st-ge-2016-reference
{"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T104","span":{"begin":6,"end":10},"obj":"Protein"},{"id":"T105","span":{"begin":235,"end":239},"obj":"Negative_regulation"},{"id":"T106","span":{"begin":243,"end":250},"obj":"Protein"}],"relations":[{"id":"R42","pred":"themeOf","subj":"T106","obj":"T105"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":") and TBK1 signaling pathways were intact. A mixed lymphocyte reaction showed that mutant BMDC only induced a weak Th1 immune response but stimulated increased Th2 cytokine production from allogeneic naïve CD4+ T cells. In conclusion, loss of Sharpin in mice significantly affects the immune func"}
bionlp-st-ge-2016-uniprot
{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T685","span":{"begin":6,"end":10},"obj":"Q9UHD2"},{"id":"T686","span":{"begin":206,"end":209},"obj":"P01730"},{"id":"T687","span":{"begin":243,"end":250},"obj":"Q9H0F6"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":") and TBK1 signaling pathways were intact. A mixed lymphocyte reaction showed that mutant BMDC only induced a weak Th1 immune response but stimulated increased Th2 cytokine production from allogeneic naïve CD4+ T cells. In conclusion, loss of Sharpin in mice significantly affects the immune func"}
test2
{"project":"test2","denotations":[{"id":"T66","span":{"begin":6,"end":10},"obj":"Protein"},{"id":"T67","span":{"begin":235,"end":239},"obj":"Negative_regulation"},{"id":"T68","span":{"begin":243,"end":250},"obj":"Protein"}],"relations":[{"id":"R34","pred":"themeOf","subj":"T68","obj":"T67"}],"text":") and TBK1 signaling pathways were intact. A mixed lymphocyte reaction showed that mutant BMDC only induced a weak Th1 immune response but stimulated increased Th2 cytokine production from allogeneic naïve CD4+ T cells. In conclusion, loss of Sharpin in mice significantly affects the immune func"}