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2_test

Id Subject Object Predicate Lexical cue
22348129-17538631-89575681 612-613 17538631 denotes 2
22348129-17538631-89575682 1729-1730 17538631 denotes 2
T51169 612-613 17538631 denotes 2
T59339 1729-1730 17538631 denotes 2

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T4014 0-10 NN denotes Production
T4015 11-13 IN denotes of
T4016 14-29 JJ denotes proinflammatory
T4017 30-39 NN denotes mediators
T4018 40-42 IN denotes by
T4019 43-47 NN denotes cpdm
T4020 48-52 NN denotes BMDC
T4021 53-55 VB denotes is
T4022 56-64 VB denotes impaired
T4023 65-75 NN denotes Incubation
T4024 76-80 IN denotes with
T4025 81-84 NN denotes LPS
T4026 85-87 CC denotes or
T4027 88-92 NN denotes poly
T4028 93-94 NN denotes I
T4029 94-95 SYM denotes :
T4030 95-96 NN denotes C
T4031 97-105 VB denotes resulted
T4032 106-108 IN denotes in
T4033 109-118 NN denotes secretion
T4034 119-121 IN denotes of
T4035 122-125 NN denotes IL6
T4036 125-126 -COMMA- denotes ,
T4037 127-134 NN denotes IL12P70
T4038 134-135 -COMMA- denotes ,
T4039 136-139 CC denotes and
T4040 140-145 NN denotes GMCSF
T4041 146-150 IN denotes from
T4042 151-155 CC denotes both
T4043 156-158 NN denotes WT
T4044 159-162 CC denotes and
T4045 163-167 NN denotes cpdm
T4046 168-172 NN denotes BMDC
T4047 172-173 -COLON- denotes ;
T4048 174-181 RB denotes however
T4049 181-182 -COMMA- denotes ,
T4050 183-187 NN denotes BMDC
T4051 188-192 IN denotes from
T4052 193-197 NN denotes cpdm
T4053 198-202 NN denotes mice
T4054 203-211 VB denotes produced
T4055 212-225 RB denotes significantly
T4056 226-230 JJ denotes less
T4057 231-233 IN denotes of
T4058 234-237 DT denotes all
T4059 238-243 CD denotes three
T4060 244-253 NN denotes cytokines
T4061 254-262 VB denotes compared
T4062 263-267 IN denotes with
T4063 268-270 JJ denotes WT
T4064 271-275 NN denotes BMDC
T4065 276-277 -LRB- denotes (
T4066 277-281 NNP denotes Fig.
T4067 282-286 NN denotes 3A–C
T4068 286-287 -COMMA- denotes ,
T4069 288-291 NN denotes E–F
T4070 291-292 -RRB- denotes )
T4071 294-297 DT denotes The
T4072 298-304 NN denotes amount
T4073 305-307 IN denotes of
T4074 308-314 JJ denotes nitric
T4075 315-320 NN denotes oxide
T4076 321-330 VB denotes generated
T4077 331-333 IN denotes by
T4078 334-340 JJ denotes mutant
T4079 341-345 NN denotes BMDC
T4080 346-349 VB denotes was
T4081 350-354 RB denotes also
T4082 355-368 RB denotes significantly
T4083 369-376 VB denotes reduced
T4084 377-385 VB denotes compared
T4085 386-390 IN denotes with
T4086 391-393 JJ denotes WT
T4087 394-399 NN denotes cells
T4088 400-401 -LRB- denotes (
T4089 401-405 NN denotes Fig.
T4090 406-408 NN denotes 3D
T4091 408-409 -RRB- denotes )
T4092 409-410 -COMMA- denotes ,
T4093 411-421 VB denotes indicating
T4094 422-430 RB denotes severely
T4095 431-440 VB denotes disrupted
T4096 441-451 NN denotes production
T4097 452-454 IN denotes of
T4098 455-470 JJ denotes proinflammatory
T4099 471-480 NN denotes mediators
T4100 481-485 IN denotes from
T4101 486-503 JJ denotes Sharpin-deficient
T4102 504-508 NN denotes BMDC
T4103 510-512 FW denotes In
T4104 513-517 FW denotes vivo
T4105 518-533 NN denotes complementation
T4106 534-538 IN denotes with
T4107 539-540 DT denotes a
T4108 541-548 NNP denotes Sharpin
T4109 549-564 JJ denotes gene-containing
T4110 565-568 NN denotes BAC
T4111 569-577 VB denotes reversed
T4112 578-581 DT denotes the
T4113 582-591 NN denotes phenotype
T4114 592-594 IN denotes of
T4115 595-598 DT denotes the
T4116 599-605 JJ denotes mutant
T4117 606-610 NN denotes mice
T4118 611-612 -LRB- denotes [
T4119 612-613 CD denotes 2
T4120 613-614 -RRB- denotes ]
T4121 614-615 -COMMA- denotes ,
T4122 616-619 CC denotes and
T4123 620-624 NN denotes BMDC
T4124 625-634 VB denotes generated
T4125 635-639 IN denotes from
T4126 640-645 DT denotes these
T4127 646-653 VB denotes rescued
T4128 654-658 NN denotes mice
T4129 659-667 VB denotes secreted
T4130 668-681 RB denotes significantly
T4131 682-686 JJ denotes more
T4132 687-694 NN denotes IL12P70
T4133 695-699 IN denotes than
T4134 700-704 NN denotes BMDC
T4135 705-709 IN denotes from
T4136 710-714 NN denotes cpdm
T4137 715-719 NN denotes mice
T4138 720-721 -LRB- denotes (
T4139 721-725 NNP denotes Fig.
T4140 726-728 NN denotes 3G
T4141 728-729 -RRB- denotes )
T4142 729-730 -COMMA- denotes ,
T4143 731-741 VB denotes supporting
T4144 742-743 DT denotes a
T4145 744-753 JJ denotes necessary
T4146 754-758 NN denotes role
T4147 759-761 IN denotes of
T4148 762-769 NN denotes SHARPIN
T4149 770-773 IN denotes for
T4150 774-777 DT denotes the
T4151 778-788 NN denotes production
T4152 789-791 IN denotes of
T4153 792-799 NN denotes IL12P70
T4154 801-803 IN denotes In
T4155 804-812 NN denotes addition
T4156 812-813 -COMMA- denotes ,
T4157 814-817 DT denotes the
T4158 818-828 NN denotes transcript
T4159 829-835 NN denotes levels
T4160 836-838 IN denotes of
T4161 839-842 DT denotes the
T4162 843-855 JJ denotes inflammatory
T4163 856-865 NN denotes cytokines
T4164 866-869 NN denotes Il6
T4165 869-870 -COMMA- denotes ,
T4166 871-878 NN denotes Il12p40
T4167 878-879 -COMMA- denotes ,
T4168 880-885 NN denotes Gmcsf
T4169 885-886 -COMMA- denotes ,
T4170 887-890 CC denotes and
T4171 891-895 NN denotes Ifnb
T4172 896-900 VB denotes were
T4173 901-909 VB denotes examined
T4174 909-910 -COMMA- denotes ,
T4175 911-914 CC denotes and
T4176 915-920 DT denotes these
T4177 921-925 VB denotes were
T4178 926-929 DT denotes all
T4179 930-943 RB denotes significantly
T4180 944-951 VB denotes reduced
T4181 952-954 IN denotes in
T4182 955-965 VB denotes stimulated
T4183 966-970 NN denotes cpdm
T4184 971-975 NN denotes BMDC
T4185 976-980 WRB denotes when
T4186 981-989 VB denotes compared
T4187 990-994 IN denotes with
T4188 995-997 JJ denotes WT
T4189 998-1006 NN denotes controls
T4190 1007-1008 -LRB- denotes (
T4191 1008-1012 NN denotes Fig.
T4192 1013-1014 CD denotes 4
T4193 1014-1015 -RRB- denotes )
T14018 1061-1070 JJ denotes Defective
T14019 1071-1081 NN denotes production
T14020 1082-1084 IN denotes of
T14021 1085-1101 JJ denotes pro-inflammatory
T14022 1102-1111 NN denotes mediators
T14023 1112-1116 IN denotes from
T14024 1117-1127 VB denotes stimulated
T14025 1128-1132 NN denotes cpdm
T14026 1133-1137 NN denotes BMDC
T14027 1139-1140 -LRB- denotes (
T14028 1140-1143 NN denotes A–D
T14029 1143-1144 -RRB- denotes )
T14030 1145-1153 JJ denotes Cultured
T14031 1154-1156 NN denotes WT
T14032 1157-1160 CC denotes and
T14033 1161-1165 NN denotes cpdm
T14034 1166-1170 NN denotes BMDC
T14035 1171-1172 -LRB- denotes (
T14036 1172-1177 CD denotes 1×105
T14037 1178-1183 NN denotes cells
T14038 1184-1186 IN denotes in
T14039 1187-1190 CD denotes 0.1
T14040 1191-1193 NN denotes ml
T14041 1194-1202 JJ denotes complete
T14042 1203-1209 NN denotes medium
T14043 1209-1210 -RRB- denotes )
T14044 1211-1215 VB denotes were
T14045 1216-1222 VB denotes washed
T14046 1223-1226 CC denotes and
T14047 1227-1237 VB denotes stimulated
T14048 1238-1242 IN denotes with
T14049 1243-1249 NN denotes medium
T14050 1249-1250 -COMMA- denotes ,
T14051 1251-1254 CD denotes 100
T14052 1255-1260 NN denotes ng/ml
T14053 1261-1264 NN denotes LPS
T14054 1265-1267 CC denotes or
T14055 1268-1270 CD denotes 25
T14056 1271-1276 NN denotes µg/ml
T14057 1277-1281 NN denotes poly
T14058 1282-1283 NN denotes I
T14059 1283-1284 -COLON- denotes :
T14060 1284-1285 NN denotes C
T14061 1286-1289 IN denotes for
T14062 1290-1292 CD denotes 24
T14063 1293-1298 NN denotes hours
T14064 1300-1312 NN denotes Supernatants
T14065 1313-1317 VB denotes were
T14066 1318-1327 VB denotes collected
T14067 1328-1331 IN denotes for
T14068 1332-1337 NN denotes ELISA
T14069 1338-1340 IN denotes of
T14070 1341-1348 NN denotes IL12P70
T14071 1348-1349 -COMMA- denotes ,
T14072 1350-1353 NN denotes IL6
T14073 1353-1354 -COMMA- denotes ,
T14074 1355-1358 CC denotes and
T14075 1359-1364 NN denotes GMCSF
T14076 1364-1365 -COMMA- denotes ,
T14077 1366-1369 CC denotes and
T14078 1370-1373 IN denotes for
T14079 1374-1388 NN denotes quantification
T14080 1389-1391 IN denotes of
T14081 1392-1398 JJ denotes nitric
T14082 1399-1404 NN denotes oxide
T14083 1405-1406 -LRB- denotes (
T14084 1406-1408 NN denotes NO
T14085 1408-1409 -RRB- denotes )
T14086 1409-1410 -LRB- denotes .
T14087 1411-1414 NN denotes (E–
T14088 1414-1415 -RRB- denotes F
T14089 1415-1423 NN denotes ) Gradie
T14090 1423-1430 NN denotes nt numb
T14091 1430-1431 -LRB- denotes e
T14092 1431-1436 CD denotes rs (1
T14093 1436-1437 -COMMA- denotes ×
T14094 1437-1442 CD denotes 104,
T14095 1442-1443 -COMMA- denotes 2
T14096 1443-1446 CC denotes ×10
T14097 1446-1451 CD denotes 4, an
T14098 1451-1456 NN denotes d 4×1
T14099 1456-1458 IN denotes 04
T14100 1459-1462 CD denotes cel
T14101 1462-1464 NN denotes ls
T14102 1465-1473 JJ denotes in 0.1 m
T14103 1473-1479 NN denotes L comp
T14104 1479-1480 -RRB- denotes l
T14105 1480-1482 IN denotes et
T14106 1482-1486 NN denotes e me
T14107 1486-1490 VB denotes dium
T14108 1490-1494 VB denotes ) of
T14109 1495-1501 NN denotes BMDC w
T14110 1501-1506 NN denotes ere u
T14111 1506-1509 NN denotes sed
T14112 1510-1521 NN denotes for100 ng/m
T14113 1540-1545 IN denotes After
T14114 1546-1548 CD denotes 24
T14115 1549-1554 NN denotes hours
T14116 1554-1555 -COMMA- denotes ,
T14117 1556-1559 DT denotes the
T14118 1560-1567 NN denotes amounts
T14119 1568-1570 IN denotes of
T14120 1571-1578 NN denotes IL12P70
T14121 1579-1582 CC denotes and
T14122 1583-1586 NN denotes IL6
T14123 1587-1591 IN denotes from
T14124 1592-1595 DT denotes the
T14125 1596-1607 NN denotes supernatant
T14126 1608-1612 VB denotes were
T14127 1613-1622 VB denotes measured.
T14128 1623-1624 -LRB- denotes (
T14129 1624-1625 NN denotes G
T14130 1625-1626 -RRB- denotes )
T14131 1627-1630 DT denotes The
T14132 1631-1635 NN denotes cpdm
T14133 1636-1640 NN denotes mice
T14134 1641-1648 VB denotes rescued
T14135 1649-1651 IN denotes by
T14136 1652-1670 JJ denotes Sharpin-containing
T14137 1671-1674 NN denotes BAC
T14138 1675-1678 VB denotes had
T14139 1679-1687 JJ denotes complete
T14140 1688-1697 NN denotes remission
T14141 1698-1700 IN denotes of
T14142 1701-1704 DT denotes the
T14143 1705-1717 JJ denotes inflammatory
T14144 1718-1727 NN denotes phenotype
T14145 1728-1729 -LRB- denotes [
T14146 1729-1730 CD denotes 2
T14147 1730-1731 -RRB- denotes ]
T14148 1733-1737 NN denotes BMDC
T14149 1738-1747 VB denotes developed
T14150 1748-1752 IN denotes from
T14151 1753-1757 NN denotes cpdm
T14152 1758-1761 CC denotes and
T14153 1762-1769 VB denotes rescued
T14154 1770-1774 NN denotes cpdm
T14155 1775-1779 NN denotes mice
T14156 1780-1784 VB denotes were
T14157 1785-1791 VB denotes plated
T14158 1792-1793 -LRB- denotes (
T14159 1793-1798 CD denotes 1×106
T14160 1799-1804 NN denotes cells
T14161 1805-1807 IN denotes in
T14162 1808-1811 CD denotes 0.3
T14163 1812-1814 NN denotes mL
T14164 1814-1815 -RRB- denotes )
T14165 1816-1819 CC denotes and
T14166 1820-1830 VB denotes stimulated
T14167 1831-1835 IN denotes with
T14168 1836-1839 CD denotes 100
T14169 1840-1845 NN denotes ng/mL
T14170 1846-1849 NN denotes LPS
T14171 1851-1856 IN denotes After
T14172 1857-1859 CD denotes 24
T14173 1860-1865 NN denotes hours
T14174 1865-1866 -COMMA- denotes ,
T14175 1867-1879 NN denotes supernatants
T14176 1880-1884 VB denotes were
T14177 1885-1894 VB denotes collected
T14178 1895-1898 IN denotes for
T14179 1899-1907 NN denotes analysis
T14180 1908-1910 IN denotes of
T14181 1911-1918 NN denotes IL12P70
T14182 1919-1929 NN denotes production
T14183 1931-1935 NN denotes Data
T14184 1936-1939 VB denotes are
T14185 1940-1954 JJ denotes representative
T14186 1955-1957 IN denotes of
T14187 1958-1963 CD denotes three
T14188 1964-1975 JJ denotes independent
T14189 1976-1988 NN denotes experiments.
T14190 1989-1990 SYM denotes *
T14191 1991-1992 NN denotes P
T14192 1992-1993 SYM denotes <
T14193 1993-1997 CD denotes 0.01
T14194 1997-1998 -COLON- denotes ;
T14195 1999-2001 SYM denotes **
T14196 2002-2003 NN denotes P
T14197 2003-2004 SYM denotes <
T14198 2004-2009 CD denotes 0.005
T14388 2055-2064 VB denotes Decreased
T14389 2065-2069 NN denotes mRNA
T14390 2070-2076 NN denotes levels
T14391 2077-2079 IN denotes of
T14392 2080-2092 JJ denotes inflammatory
T14393 2093-2102 NN denotes cytokines
T14394 2103-2107 IN denotes from
T14395 2108-2112 NN denotes cpdm
T14396 2113-2117 NN denotes BMDC
T14397 2119-2127 VB denotes Cultured
T14398 2128-2130 NN denotes WT
T14399 2131-2134 CC denotes and
T14400 2135-2139 NN denotes cpdm
T14401 2140-2144 NN denotes BMDC
T14402 2145-2146 -LRB- denotes (
T14403 2146-2151 CD denotes 5×105
T14404 2152-2157 NN denotes cells
T14405 2158-2160 IN denotes in
T14406 2161-2164 CD denotes 0.2
T14407 2165-2167 NN denotes ml
T14408 2168-2176 JJ denotes complete
T14409 2177-2183 NN denotes medium
T14410 2183-2184 -RRB- denotes )
T14411 2185-2189 VB denotes were
T14412 2190-2196 VB denotes washed
T14413 2197-2200 CC denotes and
T14414 2201-2211 VB denotes stimulated
T14415 2212-2216 IN denotes with
T14416 2217-2220 CD denotes 100
T14417 2221-2226 NN denotes ng/ml
T14418 2227-2230 NN denotes LPS
T14419 2231-2232 -LRB- denotes (
T14420 2232-2233 NN denotes A
T14421 2233-2234 -COMMA- denotes ,
T14422 2234-2235 NN denotes C
T14423 2235-2236 -COMMA- denotes ,
T14424 2236-2237 NN denotes E
T14425 2237-2238 -COMMA- denotes ,
T14426 2238-2239 NN denotes G
T14427 2239-2240 -RRB- denotes )
T14428 2241-2243 CC denotes or
T14429 2244-2246 CD denotes 25
T14430 2247-2252 NN denotes µg/ml
T14431 2253-2257 NN denotes poly
T14432 2258-2259 NN denotes I
T14433 2259-2260 SYM denotes :
T14434 2260-2261 NN denotes C
T14435 2262-2263 -LRB- denotes (
T14436 2263-2264 NN denotes B
T14437 2264-2265 -COMMA- denotes ,
T14438 2265-2266 NNP denotes D
T14439 2266-2267 -COMMA- denotes ,
T14440 2267-2268 NNP denotes F
T14441 2268-2269 -COMMA- denotes ,
T14442 2269-2270 NN denotes H
T14443 2270-2271 -RRB- denotes )
T14444 2273-2275 IN denotes At
T14445 2276-2277 CD denotes 0
T14446 2277-2278 -COMMA- denotes ,
T14447 2279-2280 CD denotes 1
T14448 2281-2284 CC denotes and
T14449 2285-2286 CD denotes 2
T14450 2287-2292 NN denotes hours
T14451 2292-2293 -COMMA- denotes ,
T14452 2294-2299 JJ denotes total
T14453 2300-2303 NN denotes RNA
T14454 2304-2307 VB denotes was
T14455 2308-2317 VB denotes extracted
T14456 2318-2321 CC denotes and
T14457 2322-2329 JJ denotes subject
T14458 2330-2332 TO denotes to
T14459 2333-2340 NN denotes qRT-PCR
T14460 2341-2343 TO denotes to
T14461 2344-2351 VB denotes measure
T14462 2352-2355 DT denotes the
T14463 2356-2366 NN denotes expression
T14464 2367-2369 IN denotes of
T14465 2370-2377 NN denotes Il12p40
T14466 2378-2379 -LRB- denotes (
T14467 2379-2380 NN denotes A
T14468 2380-2381 -COMMA- denotes ,
T14469 2381-2382 NN denotes B
T14470 2382-2383 -RRB- denotes )
T14471 2383-2384 -COMMA- denotes ,
T14472 2385-2388 NN denotes Il6
T14473 2389-2390 -LRB- denotes (
T14474 2390-2391 NN denotes C
T14475 2391-2392 -COMMA- denotes ,
T14476 2392-2393 NN denotes D
T14477 2393-2394 -RRB- denotes )
T14478 2394-2395 -COMMA- denotes ,
T14479 2396-2401 NN denotes Gmcsf
T14480 2402-2403 -LRB- denotes (
T14481 2403-2404 NN denotes E
T14482 2404-2405 -COMMA- denotes ,
T14483 2405-2406 NN denotes F
T14484 2406-2407 -RRB- denotes )
T14485 2407-2408 -COMMA- denotes ,
T14486 2409-2412 CC denotes and
T14487 2413-2417 NN denotes Ifnb
T14488 2418-2419 -LRB- denotes (
T14489 2419-2420 NN denotes G
T14490 2420-2421 -COMMA- denotes ,
T14491 2421-2422 NN denotes H
T14492 2422-2423 -RRB- denotes )
T14493 2424-2428 NN denotes mRNA
T14494 2430-2434 NN denotes Bars
T14495 2435-2444 VB denotes represent
T14496 2445-2449 JJ denotes mean
T14497 2450-2451 JJ denotes ±
T14498 2452-2454 NN denotes SD
T14499 2456-2460 NN denotes Data
T14500 2461-2464 VB denotes are
T14501 2465-2479 JJ denotes representative
T14502 2480-2482 IN denotes of
T14503 2483-2486 CD denotes two
T14504 2487-2498 JJ denotes independent
T14505 2499-2510 NN denotes experiments
R3323 T4014 T4015 arg1Of Production,of
R3324 T4014 T4018 arg1Of Production,by
R3325 T4017 T4015 arg2Of mediators,of
R3326 T4017 T4016 arg1Of mediators,proinflammatory
R3328 T4020 T4018 arg2Of BMDC,by
R3331 T4023 T4031 arg1Of Incubation,resulted
R3332 T4025 T4026 arg1Of LPS,or
R3333 T4026 T4024 arg2Of or,with
R3334 T4030 T4026 arg2Of C,or
R3335 T4030 T4027 arg1Of C,poly
R3336 T4030 T4028 arg1Of C,I
R3337 T4030 T4029 arg1Of C,:
R3338 T4031 T4032 arg1Of resulted,in
R3339 T4031 T4047 arg1Of resulted,;
R3340 T4033 T4032 arg2Of secretion,in
R3341 T4033 T4034 arg1Of secretion,of
R3342 T4033 T4041 arg1Of secretion,from
R3343 T4035 T4036 arg1Of IL6,","
R3344 T4036 T4039 arg1Of ",",and
R3345 T4037 T4036 arg2Of IL12P70,","
R3346 T4039 T4034 arg2Of and,of
R3347 T4039 T4038 arg1Of and,","
R3348 T4040 T4039 arg2Of GMCSF,and
R3349 T4043 T4044 arg1Of WT,and
R3350 T4044 T4042 arg1Of and,both
R3351 T4045 T4044 arg2Of cpdm,and
R3352 T4046 T4041 arg2Of BMDC,from
R3353 T4046 T4043 arg1Of BMDC,WT
R3354 T4046 T4045 arg1Of BMDC,cpdm
R3355 T4050 T4051 arg1Of BMDC,from
R3356 T4050 T4054 arg1Of BMDC,produced
R3357 T4053 T4051 arg2Of mice,from
R3358 T4053 T4052 arg1Of mice,cpdm
R3359 T4054 T4047 arg2Of produced,;
R3360 T4054 T4048 arg1Of produced,however
R3361 T4054 T4049 arg1Of produced,","
R3362 T4054 T4055 arg1Of produced,significantly
R3363 T4054 T4061 arg1Of produced,compared
R3364 T4056 T4054 arg2Of less,produced
R3365 T4056 T4057 arg1Of less,of
R3366 T4060 T4057 arg2Of cytokines,of
R3367 T4060 T4058 arg1Of cytokines,all
R3368 T4060 T4059 arg1Of cytokines,three
R3369 T4062 T4061 arg2Of with,compared
R3370 T4064 T4062 arg2Of BMDC,with
R3371 T4064 T4063 arg1Of BMDC,WT
R3372 T4064 T4065 arg1Of BMDC,(
R3373 T4067 T4065 arg2Of 3A–C,(
R3374 T4067 T4066 arg1Of 3A–C,Fig.
R3375 T4067 T4068 arg1Of 3A–C,","
R3376 T4069 T4068 arg2Of E–F,","
R3377 T4070 T4065 arg3Of ),(
R3378 T4072 T4071 arg1Of amount,The
R3379 T4072 T4073 arg1Of amount,of
R3380 T4072 T4080 arg1Of amount,was
R3381 T4075 T4073 arg2Of oxide,of
R3382 T4075 T4074 arg1Of oxide,nitric
R3383 T4075 T4076 arg2Of oxide,generated
R3384 T4076 T4077 arg1Of generated,by
R3385 T4079 T4077 arg2Of BMDC,by
R3386 T4079 T4078 arg1Of BMDC,mutant
R3387 T4080 T4081 arg1Of was,also
R3388 T4080 T4091 arg1Of was,)
R3389 T4080 T4092 arg1Of was,","
R3390 T4080 T4093 modOf was,indicating
R3391 T4083 T4082 arg1Of reduced,significantly
R3392 T4083 T4084 arg1Of reduced,compared
R3393 T4085 T4084 arg2Of with,compared
R3394 T4087 T4085 arg2Of cells,with
R3395 T4087 T4086 arg1Of cells,WT
R3396 T4090 T4080 arg2Of 3D,was
R3397 T4090 T4083 arg2Of 3D,reduced
R3398 T4090 T4088 arg1Of 3D,(
R3399 T4090 T4089 arg1Of 3D,Fig.
R3400 T4096 T4093 arg2Of production,indicating
R3401 T4096 T4094 arg1Of production,severely
R3402 T4096 T4095 arg2Of production,disrupted
R3403 T4096 T4097 arg1Of production,of
R3404 T4099 T4097 arg2Of mediators,of
R3405 T4099 T4098 arg1Of mediators,proinflammatory
R3406 T4099 T4100 arg1Of mediators,from
R3407 T4102 T4100 arg2Of BMDC,from
R3408 T4102 T4101 arg1Of BMDC,Sharpin-deficient
R3409 T4104 T4103 arg1Of vivo,In
R3410 T4105 T4104 arg1Of complementation,vivo
R3411 T4105 T4106 arg1Of complementation,with
R3412 T4105 T4111 arg1Of complementation,reversed
R3413 T4110 T4106 arg2Of BAC,with
R3414 T4110 T4107 arg1Of BAC,a
R3415 T4110 T4108 arg1Of BAC,Sharpin
R3416 T4110 T4109 arg1Of BAC,gene-containing
R3417 T4111 T4122 arg1Of reversed,and
R3418 T4113 T4111 arg2Of phenotype,reversed
R3419 T4113 T4112 arg1Of phenotype,the
R3420 T4113 T4114 arg1Of phenotype,of
R3421 T4117 T4114 arg2Of mice,of
R3422 T4117 T4115 arg1Of mice,the
R3423 T4117 T4116 arg1Of mice,mutant
R3424 T4117 T4118 arg1Of mice,[
R3425 T4119 T4118 arg2Of 2,[
R3426 T4120 T4118 arg3Of ],[
R3427 T4122 T4121 arg1Of and,","
R3428 T4123 T4124 arg2Of BMDC,generated
R3429 T4123 T4129 arg1Of BMDC,secreted
R3430 T4124 T4125 arg1Of generated,from
R3431 T4128 T4125 arg2Of mice,from
R3432 T4128 T4126 arg1Of mice,these
R3433 T4128 T4127 arg2Of mice,rescued
R3434 T4129 T4122 arg2Of secreted,and
R3435 T4129 T4142 arg1Of secreted,","
R3436 T4129 T4143 modOf secreted,supporting
R3437 T4131 T4130 arg1Of more,significantly
R3438 T4132 T4129 arg2Of IL12P70,secreted
R3439 T4132 T4131 arg1Of IL12P70,more
R3440 T4132 T4133 arg1Of IL12P70,than
R3441 T4134 T4133 arg2Of BMDC,than
R3442 T4134 T4135 arg1Of BMDC,from
R3443 T4137 T4135 arg2Of mice,from
R3444 T4137 T4136 arg1Of mice,cpdm
R3445 T4137 T4138 arg1Of mice,(
R3446 T4140 T4138 arg2Of 3G,(
R3447 T4140 T4139 arg1Of 3G,Fig.
R3448 T4141 T4138 arg3Of ),(
R3449 T4146 T4143 arg2Of role,supporting
R3450 T4146 T4144 arg1Of role,a
R3451 T4146 T4145 arg1Of role,necessary
R3452 T4146 T4147 arg1Of role,of
R3453 T4146 T4149 arg1Of role,for
R3454 T4148 T4147 arg2Of SHARPIN,of
R3455 T4151 T4149 arg2Of production,for
R3456 T4151 T4150 arg1Of production,the
R3457 T4151 T4152 arg1Of production,of
R3458 T4153 T4152 arg2Of IL12P70,of
R3459 T4155 T4154 arg2Of addition,In
R3460 T4159 T4157 arg1Of levels,the
R3461 T4159 T4158 arg1Of levels,transcript
R3462 T4159 T4160 arg1Of levels,of
R3463 T4159 T4172 arg1Of levels,were
R3464 T4159 T4173 arg2Of levels,examined
R3465 T4163 T4161 arg1Of cytokines,the
R3466 T4163 T4162 arg1Of cytokines,inflammatory
R3467 T4164 T4165 arg1Of Il6,","
R3468 T4165 T4167 arg1Of ",",","
R3469 T4166 T4165 arg2Of Il12p40,","
R3470 T4167 T4170 arg1Of ",",and
R3471 T4168 T4167 arg2Of Gmcsf,","
R3472 T4170 T4160 arg2Of and,of
R3473 T4170 T4163 arg1Of and,cytokines
R3474 T4170 T4169 arg1Of and,","
R3475 T4171 T4170 arg2Of Ifnb,and
R3476 T4173 T4172 arg2Of examined,were
R3477 T4173 T4175 arg1Of examined,and
R3478 T4175 T4154 arg1Of and,In
R3479 T4175 T4156 arg1Of and,","
R3480 T4175 T4174 arg1Of and,","
R3481 T4176 T4177 arg1Of these,were
R3482 T4176 T4180 arg2Of these,reduced
R3483 T4176 T4186 arg1Of these,compared
R3484 T4180 T4175 arg2Of reduced,and
R3485 T4180 T4177 arg2Of reduced,were
R3486 T4180 T4178 arg1Of reduced,all
R3487 T4180 T4179 arg1Of reduced,significantly
R3488 T4180 T4181 arg1Of reduced,in
R3489 T4180 T4185 arg1Of reduced,when
R3490 T4184 T4181 arg2Of BMDC,in
R3491 T4184 T4182 arg2Of BMDC,stimulated
R3492 T4184 T4183 arg1Of BMDC,cpdm
R3493 T4186 T4185 arg2Of compared,when
R3494 T4186 T4187 arg1Of compared,with
R3495 T4189 T4187 arg2Of controls,with
R3496 T4189 T4188 arg1Of controls,WT
R3497 T4189 T4190 arg1Of controls,(
R3498 T4191 T4190 arg2Of Fig.,(
R3499 T4191 T4192 arg1Of Fig.,4
R3500 T4193 T4190 arg3Of ),(
R11703 T14019 T14018 arg1Of production,Defective
R11704 T14019 T14020 arg1Of production,of
R11705 T14022 T14020 arg2Of mediators,of
R11706 T14022 T14021 arg1Of mediators,pro-inflammatory
R11707 T14022 T14023 arg1Of mediators,from
R11708 T14026 T14023 arg2Of BMDC,from
R11709 T14026 T14024 arg2Of BMDC,stimulated
R11710 T14026 T14025 arg1Of BMDC,cpdm
R11711 T14028 T14027 arg2Of A–D,(
R11712 T14029 T14027 arg3Of ),(
R11713 T14031 T14032 arg1Of WT,and
R11714 T14033 T14032 arg2Of cpdm,and
R11715 T14034 T14027 arg1Of BMDC,(
R11716 T14034 T14030 arg1Of BMDC,Cultured
R11717 T14034 T14031 arg1Of BMDC,WT
R11718 T14034 T14033 arg1Of BMDC,cpdm
R11719 T14034 T14035 arg1Of BMDC,(
R11720 T14034 T14044 arg1Of BMDC,were
R11721 T14034 T14045 arg2Of BMDC,washed
R11722 T14034 T14047 arg2Of BMDC,stimulated
R11723 T14037 T14035 arg2Of cells,(
R11724 T14037 T14036 arg1Of cells,1×105
R11725 T14037 T14038 arg1Of cells,in
R11726 T14042 T14038 arg2Of medium,in
R11727 T14042 T14039 arg1Of medium,0.1
R11728 T14042 T14040 arg1Of medium,ml
R11729 T14042 T14041 arg1Of medium,complete
R11730 T14043 T14035 arg3Of ),(
R11731 T14045 T14046 arg1Of washed,and
R11732 T14046 T14044 arg2Of and,were
R11733 T14046 T14048 arg1Of and,with
R11734 T14047 T14046 arg2Of stimulated,and
R11735 T14049 T14050 arg1Of medium,","
R11736 T14050 T14054 arg1Of ",",or
R11737 T14051 T14052 arg1Of 100,ng/ml
R11738 T14053 T14050 arg2Of LPS,","
R11739 T14053 T14051 arg1Of LPS,100
R11740 T14054 T14048 arg2Of or,with
R11741 T14058 T14057 arg1Of I,poly
R11742 T14058 T14059 arg1Of I,:
R11743 T14060 T14054 arg2Of C,or
R11744 T14060 T14055 arg1Of C,25
R11745 T14060 T14056 arg1Of C,µg/ml
R11746 T14060 T14058 arg1Of C,I
R11747 T14060 T14061 arg1Of C,for
R11748 T14063 T14061 arg2Of hours,for
R11749 T14063 T14062 arg1Of hours,24
R11750 T14064 T14065 arg1Of Supernatants,were
R11751 T14064 T14066 arg2Of Supernatants,collected
R11752 T14066 T14065 arg2Of collected,were
R11753 T14066 T14067 arg1Of collected,for
R11754 T14068 T14067 arg2Of ELISA,for
R11755 T14068 T14069 arg1Of ELISA,of
R11756 T14068 T14078 arg1Of ELISA,for
R11757 T14069 T14077 arg1Of of,and
R11758 T14070 T14071 arg1Of IL12P70,","
R11759 T14071 T14074 arg1Of ",",and
R11760 T14072 T14071 arg2Of IL6,","
R11761 T14074 T14069 arg2Of and,of
R11762 T14074 T14073 arg1Of and,","
R11763 T14075 T14074 arg2Of GMCSF,and
R11764 T14077 T14076 arg1Of and,","
R11765 T14078 T14077 arg2Of for,and
R11766 T14079 T14078 arg2Of quantification,for
R11767 T14079 T14080 arg1Of quantification,of
R11768 T14082 T14080 arg2Of oxide,of
R11769 T14082 T14081 arg1Of oxide,nitric
R11770 T14082 T14083 arg1Of oxide,(
R11771 T14082 T14107 modOf oxide,dium
R11772 T14084 T14083 arg2Of NO,(
R11773 T14085 T14083 arg3Of ),(
R11774 T14087 T14086 arg2Of (E–,.
R11775 T14088 T14086 arg3Of F,.
R11776 T14090 T14086 arg1Of nt numb,.
R11777 T14090 T14089 arg1Of nt numb,) Gradie
R11778 T14090 T14091 arg1Of nt numb,e
R11779 T14090 T14105 arg1Of nt numb,et
R11780 T14090 T14107 arg1Of nt numb,dium
R11781 T14090 T14108 arg2Of nt numb,) of
R11782 T14092 T14093 arg1Of rs (1,×
R11783 T14093 T14096 arg1Of ×,×10
R11784 T14094 T14093 arg2Of "104, ",×
R11785 T14096 T14091 arg2Of ×10,e
R11786 T14096 T14095 arg1Of ×10,2
R11787 T14098 T14096 arg2Of d 4×1,×10
R11788 T14098 T14097 arg1Of d 4×1,"4, an"
R11789 T14098 T14099 arg1Of d 4×1,04
R11790 T14103 T14099 arg2Of L comp,04
R11791 T14103 T14100 arg1Of L comp,cel
R11792 T14103 T14101 arg1Of L comp,ls
R11793 T14103 T14102 arg1Of L comp,in 0.1 m
R11794 T14104 T14091 arg3Of l,e
R11795 T14106 T14105 arg2Of e me,et
R11796 T14108 T14107 arg2Of ) of,dium
R11797 T14112 T14108 arg3Of for100 ng/m,) of
R11798 T14112 T14109 arg1Of for100 ng/m,BMDC w
R11799 T14112 T14110 arg1Of for100 ng/m,ere u
R11800 T14112 T14111 arg1Of for100 ng/m,sed
R11801 T14114 T14113 arg2Of 24,After
R11802 T14115 T14126 modOf hours,were
R11803 T14115 T14134 arg2Of hours,rescued
R11804 T14115 T14138 arg1Of hours,had
R11805 T14118 T14117 arg1Of amounts,the
R11806 T14118 T14119 arg1Of amounts,of
R11807 T14118 T14123 arg1Of amounts,from
R11808 T14118 T14126 arg1Of amounts,were
R11809 T14118 T14127 arg2Of amounts,measured.
R11810 T14120 T14121 arg1Of IL12P70,and
R11811 T14121 T14119 arg2Of and,of
R11812 T14122 T14121 arg2Of IL6,and
R11813 T14125 T14123 arg2Of supernatant,from
R11814 T14125 T14124 arg1Of supernatant,the
R11815 T14127 T14116 arg1Of measured.,","
R11816 T14127 T14126 arg2Of measured.,were
R11817 T14127 T14128 arg1Of measured.,(
R11818 T14129 T14128 arg2Of G,(
R11819 T14130 T14128 arg3Of ),(
R11820 T14133 T14127 arg3Of mice,measured.
R11821 T14133 T14131 arg1Of mice,The
R11822 T14133 T14132 arg1Of mice,cpdm
R11823 T14137 T14134 arg1Of BAC,rescued
R11824 T14137 T14135 arg2Of BAC,by
R11825 T14137 T14136 arg1Of BAC,Sharpin-containing
R11826 T14138 T14113 arg1Of had,After
R11827 T14138 T14145 arg1Of had,[
R11828 T14140 T14138 arg2Of remission,had
R11829 T14140 T14139 arg1Of remission,complete
R11830 T14140 T14141 arg1Of remission,of
R11831 T14144 T14141 arg2Of phenotype,of
R11832 T14144 T14142 arg1Of phenotype,the
R11833 T14144 T14143 arg1Of phenotype,inflammatory
R11834 T14146 T14145 arg2Of 2,[
R11835 T14147 T14145 arg3Of ],[
R11836 T14148 T14149 arg1Of BMDC,developed
R11837 T14148 T14153 arg1Of BMDC,rescued
R11838 T14148 T14166 arg2Of BMDC,stimulated
R11839 T14149 T14150 arg1Of developed,from
R11840 T14149 T14152 arg1Of developed,and
R11841 T14151 T14150 arg2Of cpdm,from
R11842 T14153 T14161 arg1Of rescued,in
R11843 T14153 T14165 arg1Of rescued,and
R11844 T14154 T14156 modOf cpdm,were
R11845 T14155 T14156 arg1Of mice,were
R11846 T14155 T14157 arg2Of mice,plated
R11847 T14157 T14156 arg2Of plated,were
R11848 T14160 T14153 arg2Of cells,rescued
R11849 T14160 T14154 arg1Of cells,cpdm
R11850 T14160 T14158 arg1Of cells,(
R11851 T14160 T14159 arg1Of cells,1×106
R11852 T14163 T14161 arg2Of mL,in
R11853 T14163 T14162 arg1Of mL,0.3
R11854 T14163 T14164 arg1Of mL,)
R11855 T14165 T14152 arg2Of and,and
R11856 T14166 T14165 arg2Of stimulated,and
R11857 T14166 T14167 arg1Of stimulated,with
R11858 T14168 T14169 arg1Of 100,ng/mL
R11859 T14170 T14167 arg2Of LPS,with
R11860 T14170 T14168 arg1Of LPS,100
R11861 T14173 T14171 arg2Of hours,After
R11862 T14173 T14172 arg1Of hours,24
R11863 T14175 T14176 arg1Of supernatants,were
R11864 T14175 T14177 arg2Of supernatants,collected
R11865 T14177 T14171 arg1Of collected,After
R11866 T14177 T14174 arg1Of collected,","
R11867 T14177 T14176 arg2Of collected,were
R11868 T14177 T14178 arg1Of collected,for
R11869 T14179 T14178 arg2Of analysis,for
R11870 T14179 T14180 arg1Of analysis,of
R11871 T14182 T14180 arg2Of production,of
R11872 T14182 T14181 arg1Of production,IL12P70
R11873 T14183 T14184 arg1Of Data,are
R11874 T14183 T14185 arg1Of Data,representative
R11875 T14185 T14184 arg2Of representative,are
R11876 T14185 T14186 arg1Of representative,of
R11877 T14185 T14193 arg1Of representative,0.01
R11878 T14189 T14186 arg2Of experiments.,of
R11879 T14189 T14187 arg1Of experiments.,three
R11880 T14189 T14188 arg1Of experiments.,independent
R11881 T14193 T14190 arg1Of 0.01,*
R11882 T14193 T14191 arg1Of 0.01,P
R11883 T14193 T14192 arg1Of 0.01,<
R11884 T14193 T14194 arg1Of 0.01,;
R11885 T14198 T14194 arg2Of 0.005,;
R11886 T14198 T14195 arg1Of 0.005,**
R11887 T14198 T14196 arg1Of 0.005,P
R11888 T14198 T14197 arg1Of 0.005,<
R12030 T14390 T14388 arg2Of levels,Decreased
R12031 T14390 T14389 arg1Of levels,mRNA
R12032 T14390 T14391 arg1Of levels,of
R12033 T14393 T14391 arg2Of cytokines,of
R12034 T14393 T14392 arg1Of cytokines,inflammatory
R12035 T14393 T14394 arg1Of cytokines,from
R12036 T14396 T14394 arg2Of BMDC,from
R12037 T14396 T14395 arg1Of BMDC,cpdm
R12038 T14398 T14399 arg1Of WT,and
R12039 T14400 T14399 arg2Of cpdm,and
R12040 T14401 T14397 arg2Of BMDC,Cultured
R12041 T14401 T14398 arg1Of BMDC,WT
R12042 T14401 T14400 arg1Of BMDC,cpdm
R12043 T14401 T14402 arg1Of BMDC,(
R12044 T14401 T14411 arg1Of BMDC,were
R12045 T14401 T14412 arg2Of BMDC,washed
R12046 T14401 T14414 arg2Of BMDC,stimulated
R12047 T14404 T14402 arg2Of cells,(
R12048 T14404 T14403 arg1Of cells,5×105
R12049 T14404 T14405 arg1Of cells,in
R12050 T14409 T14405 arg2Of medium,in
R12051 T14409 T14406 arg1Of medium,0.2
R12052 T14409 T14407 arg1Of medium,ml
R12053 T14409 T14408 arg1Of medium,complete
R12054 T14410 T14402 arg3Of ),(
R12055 T14412 T14413 arg1Of washed,and
R12056 T14413 T14411 arg2Of and,were
R12057 T14413 T14415 arg1Of and,with
R12058 T14414 T14413 arg2Of stimulated,and
R12059 T14416 T14417 arg1Of 100,ng/ml
R12060 T14418 T14416 arg1Of LPS,100
R12061 T14418 T14419 arg1Of LPS,(
R12062 T14418 T14428 arg1Of LPS,or
R12063 T14420 T14421 arg1Of A,","
R12064 T14421 T14423 arg1Of ",",","
R12065 T14422 T14421 arg2Of C,","
R12066 T14423 T14419 arg2Of ",",(
R12067 T14423 T14425 arg1Of ",",","
R12068 T14424 T14423 arg2Of E,","
R12069 T14426 T14425 arg2Of G,","
R12070 T14427 T14419 arg3Of ),(
R12071 T14428 T14415 arg2Of or,with
R12072 T14434 T14428 arg2Of C,or
R12073 T14434 T14429 arg1Of C,25
R12074 T14434 T14430 arg1Of C,µg/ml
R12075 T14434 T14431 arg1Of C,poly
R12076 T14434 T14432 arg1Of C,I
R12077 T14434 T14433 arg1Of C,:
R12078 T14434 T14435 arg1Of C,(
R12079 T14436 T14435 arg2Of B,(
R12080 T14436 T14437 arg1Of B,","
R12081 T14436 T14441 arg1Of B,","
R12082 T14436 T14442 arg1Of B,H
R12083 T14438 T14439 arg1Of D,","
R12084 T14439 T14437 arg2Of ",",","
R12085 T14440 T14439 arg2Of F,","
R12086 T14443 T14435 arg3Of ),(
R12087 T14445 T14446 arg1Of 0,","
R12088 T14446 T14448 arg1Of ",",and
R12089 T14447 T14446 arg2Of 1,","
R12090 T14449 T14448 arg2Of 2,and
R12091 T14450 T14444 arg2Of hours,At
R12092 T14450 T14445 arg1Of hours,0
R12093 T14450 T14447 arg1Of hours,1
R12094 T14450 T14449 arg1Of hours,2
R12095 T14453 T14452 arg1Of RNA,total
R12096 T14453 T14454 arg1Of RNA,was
R12097 T14453 T14455 arg2Of RNA,extracted
R12098 T14453 T14457 arg1Of RNA,subject
R12099 T14455 T14456 arg1Of extracted,and
R12100 T14456 T14444 arg1Of and,At
R12101 T14456 T14451 arg1Of and,","
R12102 T14456 T14454 arg2Of and,was
R12103 T14457 T14456 arg2Of subject,and
R12104 T14457 T14458 arg1Of subject,to
R12105 T14459 T14458 arg2Of qRT-PCR,to
R12106 T14459 T14460 modOf qRT-PCR,to
R12107 T14461 T14460 arg1Of measure,to
R12108 T14463 T14464 arg1Of expression,of
R12109 T14463 T14478 arg1Of expression,","
R12110 T14465 T14466 arg1Of Il12p40,(
R12111 T14465 T14471 arg1Of Il12p40,","
R12112 T14467 T14466 arg2Of A,(
R12113 T14467 T14468 arg1Of A,","
R12114 T14469 T14468 arg2Of B,","
R12115 T14470 T14466 arg3Of ),(
R12116 T14471 T14464 arg2Of ",",of
R12117 T14471 T14473 arg1Of ",",(
R12118 T14472 T14471 arg2Of Il6,","
R12119 T14474 T14473 arg2Of C,(
R12120 T14474 T14475 arg1Of C,","
R12121 T14476 T14475 arg2Of D,","
R12122 T14477 T14473 arg3Of ),(
R12123 T14478 T14461 arg2Of ",",measure
R12124 T14478 T14462 arg1Of ",",the
R12125 T14479 T14480 arg1Of Gmcsf,(
R12126 T14479 T14486 arg1Of Gmcsf,and
R12127 T14481 T14480 arg2Of E,(
R12128 T14481 T14482 arg1Of E,","
R12129 T14483 T14482 arg2Of F,","
R12130 T14484 T14480 arg3Of ),(
R12131 T14486 T14478 arg2Of and,","
R12132 T14486 T14485 arg1Of and,","
R12133 T14487 T14488 arg1Of Ifnb,(
R12134 T14489 T14488 arg2Of G,(
R12135 T14489 T14490 arg1Of G,","
R12136 T14489 T14491 arg1Of G,H
R12137 T14492 T14488 arg3Of ),(
R12138 T14493 T14486 arg2Of mRNA,and
R12139 T14493 T14487 arg1Of mRNA,Ifnb
R12140 T14494 T14495 arg1Of Bars,represent
R12141 T14498 T14495 arg2Of SD,represent
R12142 T14498 T14496 arg1Of SD,mean
R12143 T14498 T14497 arg1Of SD,±
R12144 T14499 T14500 arg1Of Data,are
R12145 T14499 T14501 arg1Of Data,representative
R12146 T14501 T14500 arg2Of representative,are
R12147 T14501 T14502 arg1Of representative,of
R12148 T14505 T14502 arg2Of experiments,of
R12149 T14505 T14503 arg1Of experiments,two
R12150 T14505 T14504 arg1Of experiments,independent
R3321 T4014 T4021 arg1Of Production,is
R3322 T4014 T4022 arg2Of Production,impaired
R3327 T4020 T4019 arg1Of BMDC,cpdm
R3329 T4022 T4021 arg2Of impaired,is
R3330 T4023 T4024 arg1Of Incubation,with

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T4194 234-253 Anaphor denotes all three cytokines
T4195 122-125 Antecedent denotes IL6
T4196 140-145 Antecedent denotes GMCSF
R3501 T4194 T4195 boundBy all three cytokines,IL6
R3502 T4194 T4196 boundBy all three cytokines,GMCSF

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T3828 0-10 NN denotes Production
T3829 11-13 IN denotes of
T3830 14-29 JJ denotes proinflammatory
T3831 30-39 NNS denotes mediators
T3832 40-42 IN denotes by
T3833 43-47 NN denotes cpdm
T3834 48-52 NNP denotes BMDC
T3835 53-55 VBZ denotes is
T3836 56-64 VBN denotes impaired
T3837 65-75 NNP denotes Incubation
T3838 76-80 IN denotes with
T3839 81-84 NNP denotes LPS
T3840 85-87 CC denotes or
T3841 88-92 RB denotes poly
T3842 93-94 PRP denotes I
T3843 94-95 : denotes :
T3844 95-96 NNP denotes C
T3845 97-105 VBD denotes resulted
T3846 106-108 IN denotes in
T3847 109-118 NN denotes secretion
T3848 119-121 IN denotes of
T3849 122-125 NNP denotes IL6
T3850 125-126 , denotes ,
T3851 127-134 NNP denotes IL12P70
T3852 134-135 , denotes ,
T3853 136-139 CC denotes and
T3854 140-145 NNP denotes GMCSF
T3855 146-150 IN denotes from
T3856 151-155 DT denotes both
T3857 156-158 NNP denotes WT
T3858 159-162 CC denotes and
T3859 163-167 VB denotes cpdm
T3860 168-172 NNP denotes BMDC
T3861 172-173 : denotes ;
T3862 174-181 RB denotes however
T3863 181-182 , denotes ,
T3864 183-187 NNP denotes BMDC
T3865 188-192 IN denotes from
T3866 193-197 NN denotes cpdm
T3867 198-202 NNS denotes mice
T3868 203-211 VBD denotes produced
T3869 212-225 RB denotes significantly
T3870 226-230 JJR denotes less
T3871 231-233 IN denotes of
T3872 234-237 DT denotes all
T3873 238-243 CD denotes three
T3874 244-253 NNS denotes cytokines
T3875 254-262 VBN denotes compared
T3876 263-267 IN denotes with
T3877 268-270 NNP denotes WT
T3878 271-275 NNP denotes BMDC
T3879 276-277 -LRB- denotes (
T3880 277-281 NNP denotes Fig.
T3881 282-284 NNP denotes 3A
T3882 285-286 NNP denotes C
T3883 286-287 , denotes ,
T3884 288-289 NNP denotes E
T3885 290-291 NN denotes F
T3886 291-292 -RRB- denotes )
T3887 292-293 . denotes .
T3888 294-297 DT denotes The
T3889 298-304 NN denotes amount
T3890 305-307 IN denotes of
T3891 308-314 JJ denotes nitric
T3892 315-320 NN denotes oxide
T3893 321-330 VBN denotes generated
T3894 331-333 IN denotes by
T3895 334-340 JJ denotes mutant
T3896 341-345 NNP denotes BMDC
T3897 346-349 VBD denotes was
T3898 350-354 RB denotes also
T3899 355-368 RB denotes significantly
T3900 369-376 VBN denotes reduced
T3901 377-385 VBN denotes compared
T3902 386-390 IN denotes with
T3903 391-393 NNP denotes WT
T3904 394-399 NNS denotes cells
T3905 400-401 -LRB- denotes (
T3906 401-405 NNP denotes Fig.
T3907 406-408 NNP denotes 3D
T3908 408-409 -RRB- denotes )
T3909 409-410 , denotes ,
T3910 411-421 VBG denotes indicating
T3911 422-430 RB denotes severely
T3912 431-440 VBN denotes disrupted
T3913 441-451 NN denotes production
T3914 452-454 IN denotes of
T3915 455-470 JJ denotes proinflammatory
T3916 471-480 NNS denotes mediators
T3917 481-485 IN denotes from
T3918 486-503 JJ denotes Sharpin-deficient
T3919 504-508 NNP denotes BMDC
T3920 508-509 . denotes .
T3921 510-512 IN denotes In
T3922 513-517 NN denotes vivo
T3923 518-533 NN denotes complementation
T3924 534-538 IN denotes with
T3925 539-540 DT denotes a
T3926 541-548 NNP denotes Sharpin
T3927 549-564 NN denotes gene-containing
T3928 565-568 NNP denotes BAC
T3929 569-577 VBD denotes reversed
T3930 578-581 DT denotes the
T3931 582-591 NN denotes phenotype
T3932 592-594 IN denotes of
T3933 595-598 DT denotes the
T3934 599-605 JJ denotes mutant
T3935 606-610 NNS denotes mice
T3936 611-612 VBP denotes [
T3937 612-613 CD denotes 2
T3938 613-614 NNP denotes ]
T3939 614-615 , denotes ,
T3940 616-619 CC denotes and
T3941 620-624 NNP denotes BMDC
T3942 625-634 VBD denotes generated
T3943 635-639 IN denotes from
T3944 640-645 DT denotes these
T3945 646-653 VBN denotes rescued
T3946 654-658 NNS denotes mice
T3947 659-667 VBD denotes secreted
T3948 668-681 RB denotes significantly
T3949 682-686 RBR denotes more
T3950 687-694 JJ denotes IL12P70
T3951 695-699 IN denotes than
T3952 700-704 NNP denotes BMDC
T3953 705-709 IN denotes from
T3954 710-714 NN denotes cpdm
T3955 715-719 NNS denotes mice
T3956 720-721 -LRB- denotes (
T3957 721-725 NNP denotes Fig.
T3958 726-728 NNP denotes 3G
T3959 728-729 -RRB- denotes )
T3960 729-730 , denotes ,
T3961 731-741 VBG denotes supporting
T3962 742-743 DT denotes a
T3963 744-753 JJ denotes necessary
T3964 754-758 NN denotes role
T3965 759-761 IN denotes of
T3966 762-769 NNP denotes SHARPIN
T3967 770-773 IN denotes for
T3968 774-777 DT denotes the
T3969 778-788 NN denotes production
T3970 789-791 IN denotes of
T3971 792-799 NNP denotes IL12P70
T3972 799-800 . denotes .
T3973 801-803 IN denotes In
T3974 804-812 NN denotes addition
T3975 812-813 , denotes ,
T3976 814-817 DT denotes the
T3977 818-828 NN denotes transcript
T3978 829-835 NNS denotes levels
T3979 836-838 IN denotes of
T3980 839-842 DT denotes the
T3981 843-855 JJ denotes inflammatory
T3982 856-865 NNS denotes cytokines
T3983 866-869 NNP denotes Il6
T3984 869-870 , denotes ,
T3985 871-878 NNP denotes Il12p40
T3986 878-879 , denotes ,
T3987 880-885 NNP denotes Gmcsf
T3988 885-886 , denotes ,
T3989 887-890 CC denotes and
T3990 891-895 NNP denotes Ifnb
T3991 896-900 VBD denotes were
T3992 901-909 VBN denotes examined
T3993 909-910 , denotes ,
T3994 911-914 CC denotes and
T3995 915-920 DT denotes these
T3996 921-925 VBD denotes were
T3997 926-929 DT denotes all
T3998 930-943 RB denotes significantly
T3999 944-951 VBN denotes reduced
T4000 952-954 IN denotes in
T4001 955-965 VBN denotes stimulated
T4002 966-970 NN denotes cpdm
T4003 971-975 NNP denotes BMDC
T4004 976-980 WRB denotes when
T4005 981-989 VBN denotes compared
T4006 990-994 IN denotes with
T4007 995-997 NNP denotes WT
T4008 998-1006 NNS denotes controls
T4009 1007-1008 -LRB- denotes (
T4010 1008-1012 JJ denotes Fig.
T4011 1013-1014 CD denotes 4
T4012 1014-1015 -RRB- denotes )
T4013 1015-1016 . denotes .
T13813 1061-1070 JJ denotes Defective
T13814 1071-1081 NN denotes production
T13815 1082-1084 IN denotes of
T13816 1085-1101 JJ denotes pro-inflammatory
T13817 1102-1111 NNS denotes mediators
T13818 1112-1116 IN denotes from
T13819 1117-1127 VBN denotes stimulated
T13820 1128-1132 NN denotes cpdm
T13821 1133-1137 NNP denotes BMDC
T13822 1137-1138 . denotes .
T13823 1139-1140 -LRB- denotes (
T13824 1140-1141 DT denotes A
T13825 1142-1143 NNP denotes D
T13826 1143-1144 -RRB- denotes )
T13827 1145-1153 NNP denotes Cultured
T13828 1154-1156 NNP denotes WT
T13829 1157-1160 CC denotes and
T13830 1161-1165 VB denotes cpdm
T13831 1166-1170 NNP denotes BMDC
T13832 1171-1172 -LRB- denotes (
T13833 1172-1173 CD denotes 1
T13834 1173-1174 CD denotes ×
T13835 1174-1177 CD denotes 105
T13836 1178-1183 NNS denotes cells
T13837 1184-1186 IN denotes in
T13838 1187-1190 CD denotes 0.1
T13839 1191-1193 NN denotes ml
T13840 1194-1202 JJ denotes complete
T13841 1203-1209 NN denotes medium
T13842 1209-1210 -RRB- denotes )
T13843 1211-1215 VBD denotes were
T13844 1216-1222 VBN denotes washed
T13845 1223-1226 CC denotes and
T13846 1227-1237 VBN denotes stimulated
T13847 1238-1242 IN denotes with
T13848 1243-1249 NN denotes medium
T13849 1249-1250 , denotes ,
T13850 1251-1254 CD denotes 100
T13851 1255-1260 JJ denotes ng/ml
T13852 1261-1264 NNP denotes LPS
T13853 1265-1267 CC denotes or
T13854 1268-1270 CD denotes 25
T13855 1271-1273 NN denotes µg
T13856 1273-1274 NN denotes /
T13857 1274-1276 NN denotes ml
T13858 1277-1281 NN denotes poly
T13859 1282-1283 PRP denotes I
T13860 1283-1284 : denotes :
T13861 1284-1285 NNP denotes C
T13862 1286-1289 IN denotes for
T13863 1290-1292 CD denotes 24
T13864 1293-1298 NNS denotes hours
T13865 1298-1299 . denotes .
T13866 1300-1312 NNS denotes Supernatants
T13867 1313-1317 VBD denotes were
T13868 1318-1327 VBN denotes collected
T13869 1328-1331 IN denotes for
T13870 1332-1337 NNP denotes ELISA
T13871 1338-1340 IN denotes of
T13872 1341-1348 NNP denotes IL12P70
T13873 1348-1349 , denotes ,
T13874 1350-1353 NNP denotes IL6
T13875 1353-1354 , denotes ,
T13876 1355-1358 CC denotes and
T13877 1359-1364 NNP denotes GMCSF
T13878 1364-1365 , denotes ,
T13879 1366-1369 CC denotes and
T13880 1370-1373 IN denotes for
T13881 1374-1388 NN denotes quantification
T13882 1389-1391 IN denotes of
T13883 1392-1398 JJ denotes nitric
T13884 1399-1404 NN denotes oxide
T13885 1405-1406 -LRB- denotes (
T13886 1406-1408 UH denotes NO
T13887 1408-1409 -RRB- denotes )
T13888 1409-1410 . denotes .
T13889 1411-1412 -LRB- denotes (
T13890 1412-1413 NNP denotes E
T13891 1414-1415 NN denotes F
T13892 1415-1416 -RRB- denotes )
T13893 1417-1425 NNP denotes Gradient
T13894 1426-1433 NNS denotes numbers
T13895 1434-1435 -LRB- denotes (
T13896 1435-1436 CD denotes 1
T13897 1436-1437 CD denotes ×
T13898 1437-1440 CD denotes 104
T13899 1440-1441 , denotes ,
T13900 1442-1443 CD denotes 2
T13901 1443-1444 CD denotes ×
T13902 1444-1447 CD denotes 104
T13903 1447-1448 , denotes ,
T13904 1449-1452 CC denotes and
T13905 1453-1454 CD denotes 4
T13906 1454-1455 NN denotes ×
T13907 1455-1458 CD denotes 104
T13908 1459-1464 NNS denotes cells
T13909 1465-1467 IN denotes in
T13910 1468-1471 CD denotes 0.1
T13911 1472-1474 NNP denotes mL
T13912 1475-1483 JJ denotes complete
T13913 1484-1490 NN denotes medium
T13914 1490-1491 -RRB- denotes )
T13915 1492-1494 IN denotes of
T13916 1495-1499 NNP denotes BMDC
T13917 1500-1504 VBD denotes were
T13918 1505-1509 VBN denotes used
T13919 1510-1516 CD denotes for100
T13920 1517-1522 NNP denotes ng/mL
T13921 1523-1526 NNP denotes LPS
T13922 1527-1538 NN denotes stimulation
T13923 1538-1539 . denotes .
T13924 1540-1545 IN denotes After
T13925 1546-1548 CD denotes 24
T13926 1549-1554 NNS denotes hours
T13927 1554-1555 , denotes ,
T13928 1556-1559 DT denotes the
T13929 1560-1567 NNS denotes amounts
T13930 1568-1570 IN denotes of
T13931 1571-1578 NNP denotes IL12P70
T13932 1579-1582 CC denotes and
T13933 1583-1586 NNP denotes IL6
T13934 1587-1591 IN denotes from
T13935 1592-1595 DT denotes the
T13936 1596-1607 JJ denotes supernatant
T13937 1608-1612 VBD denotes were
T13938 1613-1621 VBN denotes measured
T13939 1621-1622 . denotes .
T13940 1623-1624 -LRB- denotes (
T13941 1624-1625 NNP denotes G
T13942 1625-1626 -RRB- denotes )
T13943 1627-1630 DT denotes The
T13944 1631-1635 NN denotes cpdm
T13945 1636-1640 NNS denotes mice
T13946 1641-1648 VBN denotes rescued
T13947 1649-1651 IN denotes by
T13948 1652-1670 VBG denotes Sharpin-containing
T13949 1671-1674 NNP denotes BAC
T13950 1675-1678 VBD denotes had
T13951 1679-1687 JJ denotes complete
T13952 1688-1697 NN denotes remission
T13953 1698-1700 IN denotes of
T13954 1701-1704 DT denotes the
T13955 1705-1717 JJ denotes inflammatory
T13956 1718-1727 NN denotes phenotype
T13957 1728-1729 NN denotes [
T13958 1729-1730 CD denotes 2
T13959 1730-1731 NNP denotes ]
T13960 1731-1732 . denotes .
T13961 1733-1737 NNP denotes BMDC
T13962 1738-1747 VBD denotes developed
T13963 1748-1752 IN denotes from
T13964 1753-1757 NN denotes cpdm
T13965 1758-1761 CC denotes and
T13966 1762-1769 VBD denotes rescued
T13967 1770-1774 NN denotes cpdm
T13968 1775-1779 NNS denotes mice
T13969 1780-1784 VBD denotes were
T13970 1785-1791 VBN denotes plated
T13971 1792-1793 -LRB- denotes (
T13972 1793-1794 CD denotes 1
T13973 1794-1795 CD denotes ×
T13974 1795-1798 CD denotes 106
T13975 1799-1804 NNS denotes cells
T13976 1805-1807 IN denotes in
T13977 1808-1811 CD denotes 0.3
T13978 1812-1814 NNP denotes mL
T13979 1814-1815 -RRB- denotes )
T13980 1816-1819 CC denotes and
T13981 1820-1830 VBN denotes stimulated
T13982 1831-1835 IN denotes with
T13983 1836-1839 CD denotes 100
T13984 1840-1845 NNP denotes ng/mL
T13985 1846-1849 NNP denotes LPS
T13986 1849-1850 . denotes .
T13987 1851-1856 IN denotes After
T13988 1857-1859 CD denotes 24
T13989 1860-1865 NNS denotes hours
T13990 1865-1866 , denotes ,
T13991 1867-1879 NNS denotes supernatants
T13992 1880-1884 VBD denotes were
T13993 1885-1894 VBN denotes collected
T13994 1895-1898 IN denotes for
T13995 1899-1907 NN denotes analysis
T13996 1908-1910 IN denotes of
T13997 1911-1918 CD denotes IL12P70
T13998 1919-1929 NN denotes production
T13999 1929-1930 . denotes .
T14000 1931-1935 NNS denotes Data
T14001 1936-1939 VBP denotes are
T14002 1940-1954 NN denotes representative
T14003 1955-1957 IN denotes of
T14004 1958-1963 CD denotes three
T14005 1964-1975 JJ denotes independent
T14006 1976-1987 NNS denotes experiments
T14007 1987-1988 . denotes .
T14008 1989-1990 SYM denotes *
T14009 1991-1992 NN denotes P
T14010 1992-1993 NN denotes <
T14011 1993-1997 CD denotes 0.01
T14012 1997-1998 : denotes ;
T14013 1999-2001 SYM denotes **
T14014 2002-2003 FW denotes P
T14015 2003-2004 FW denotes <
T14016 2004-2009 CD denotes 0.005
T14017 2009-2010 . denotes .
T14261 2055-2064 JJ denotes Decreased
T14262 2065-2069 NN denotes mRNA
T14263 2070-2076 NNS denotes levels
T14264 2077-2079 IN denotes of
T14265 2080-2092 JJ denotes inflammatory
T14266 2093-2102 NNS denotes cytokines
T14267 2103-2107 IN denotes from
T14268 2108-2112 NN denotes cpdm
T14269 2113-2117 NNP denotes BMDC
T14270 2117-2118 . denotes .
T14271 2119-2127 NNP denotes Cultured
T14272 2128-2130 NNP denotes WT
T14273 2131-2134 CC denotes and
T14274 2135-2139 VB denotes cpdm
T14275 2140-2144 NNP denotes BMDC
T14276 2145-2146 -LRB- denotes (
T14277 2146-2147 CD denotes 5
T14278 2147-2148 CD denotes ×
T14279 2148-2151 CD denotes 105
T14280 2152-2157 NNS denotes cells
T14281 2158-2160 IN denotes in
T14282 2161-2164 CD denotes 0.2
T14283 2165-2167 NN denotes ml
T14284 2168-2176 JJ denotes complete
T14285 2177-2183 NN denotes medium
T14286 2183-2184 -RRB- denotes )
T14287 2185-2189 VBD denotes were
T14288 2190-2196 VBN denotes washed
T14289 2197-2200 CC denotes and
T14290 2201-2211 VBN denotes stimulated
T14291 2212-2216 IN denotes with
T14292 2217-2220 CD denotes 100
T14293 2221-2226 JJ denotes ng/ml
T14294 2227-2230 NNP denotes LPS
T14295 2231-2232 -LRB- denotes (
T14296 2232-2233 NNP denotes A
T14297 2233-2234 , denotes ,
T14298 2234-2235 NNP denotes C
T14299 2235-2236 , denotes ,
T14300 2236-2237 NNP denotes E
T14301 2237-2238 , denotes ,
T14302 2238-2239 NNP denotes G
T14303 2239-2240 -RRB- denotes )
T14304 2241-2243 CC denotes or
T14305 2244-2246 CD denotes 25
T14306 2247-2249 NN denotes µg
T14307 2249-2250 NN denotes /
T14308 2250-2252 NN denotes ml
T14309 2253-2257 NN denotes poly
T14310 2258-2259 PRP denotes I
T14311 2259-2260 : denotes :
T14312 2260-2261 NNP denotes C
T14313 2262-2263 -LRB- denotes (
T14314 2263-2264 NNP denotes B
T14315 2264-2265 , denotes ,
T14316 2265-2266 NNP denotes D
T14317 2266-2267 , denotes ,
T14318 2267-2268 NN denotes F
T14319 2268-2269 , denotes ,
T14320 2269-2270 NNP denotes H
T14321 2270-2271 -RRB- denotes )
T14322 2271-2272 . denotes .
T14323 2273-2275 IN denotes At
T14324 2276-2277 CD denotes 0
T14325 2277-2278 , denotes ,
T14326 2279-2280 CD denotes 1
T14327 2281-2284 CC denotes and
T14328 2285-2286 CD denotes 2
T14329 2287-2292 NNS denotes hours
T14330 2292-2293 , denotes ,
T14331 2294-2299 JJ denotes total
T14332 2300-2303 NNP denotes RNA
T14333 2304-2307 VBD denotes was
T14334 2308-2317 VBN denotes extracted
T14335 2318-2321 CC denotes and
T14336 2322-2329 JJ denotes subject
T14337 2330-2332 TO denotes to
T14338 2333-2340 NNP denotes qRT-PCR
T14339 2341-2343 TO denotes to
T14340 2344-2351 VB denotes measure
T14341 2352-2355 DT denotes the
T14342 2356-2366 NN denotes expression
T14343 2367-2369 IN denotes of
T14344 2370-2377 NNP denotes Il12p40
T14345 2378-2379 -LRB- denotes (
T14346 2379-2380 NNP denotes A
T14347 2380-2381 , denotes ,
T14348 2381-2382 NNP denotes B
T14349 2382-2383 -RRB- denotes )
T14350 2383-2384 , denotes ,
T14351 2385-2388 NNP denotes Il6
T14352 2389-2390 -LRB- denotes (
T14353 2390-2391 NNP denotes C
T14354 2391-2392 , denotes ,
T14355 2392-2393 NNP denotes D
T14356 2393-2394 -RRB- denotes )
T14357 2394-2395 , denotes ,
T14358 2396-2401 NNP denotes Gmcsf
T14359 2402-2403 -LRB- denotes (
T14360 2403-2404 NNP denotes E
T14361 2404-2405 , denotes ,
T14362 2405-2406 NN denotes F
T14363 2406-2407 -RRB- denotes )
T14364 2407-2408 , denotes ,
T14365 2409-2412 CC denotes and
T14366 2413-2417 NNP denotes Ifnb
T14367 2418-2419 -LRB- denotes (
T14368 2419-2420 NNP denotes G
T14369 2420-2421 , denotes ,
T14370 2421-2422 NNP denotes H
T14371 2422-2423 -RRB- denotes )
T14372 2424-2428 NNP denotes mRNA
T14373 2428-2429 . denotes .
T14374 2430-2434 NNS denotes Bars
T14375 2435-2444 VBP denotes represent
T14376 2445-2449 JJ denotes mean
T14377 2450-2451 NN denotes ±
T14378 2452-2454 NNP denotes SD
T14379 2454-2455 . denotes .
T14380 2456-2460 NNS denotes Data
T14381 2461-2464 VBP denotes are
T14382 2465-2479 NN denotes representative
T14383 2480-2482 IN denotes of
T14384 2483-2486 CD denotes two
T14385 2487-2498 JJ denotes independent
T14386 2499-2510 NNS denotes experiments
T14387 2510-2511 . denotes .
R3135 T3828 T3836 nsubjpass Production,impaired
R3136 T3829 T3828 prep of,Production
R3137 T3830 T3831 amod proinflammatory,mediators
R3138 T3831 T3829 pobj mediators,of
R3139 T3832 T3828 prep by,Production
R3140 T3833 T3834 compound cpdm,BMDC
R3141 T3834 T3832 pobj BMDC,by
R3142 T3835 T3836 auxpass is,impaired
R3143 T3836 T3868 ccomp impaired,produced
R3144 T3837 T3836 dobj Incubation,impaired
R3145 T3838 T3836 prep with,impaired
R3146 T3839 T3838 pobj LPS,with
R3147 T3840 T3836 cc or,impaired
R3148 T3841 T3845 advmod poly,resulted
R3149 T3842 T3845 nsubj I,resulted
R3150 T3843 T3845 punct :,resulted
R3151 T3844 T3845 nsubj C,resulted
R3152 T3845 T3836 conj resulted,impaired
R3153 T3846 T3845 prep in,resulted
R3154 T3847 T3846 pobj secretion,in
R3155 T3848 T3847 prep of,secretion
R3156 T3849 T3848 pobj IL6,of
R3157 T3850 T3849 punct ",",IL6
R3158 T3851 T3849 conj IL12P70,IL6
R3159 T3852 T3851 punct ",",IL12P70
R3160 T3853 T3851 cc and,IL12P70
R3161 T3854 T3851 conj GMCSF,IL12P70
R3162 T3855 T3845 prep from,resulted
R3163 T3856 T3857 preconj both,WT
R3164 T3857 T3855 pobj WT,from
R3165 T3858 T3857 cc and,WT
R3166 T3859 T3860 compound cpdm,BMDC
R3167 T3860 T3857 conj BMDC,WT
R3168 T3861 T3868 punct ;,produced
R3169 T3862 T3868 advmod however,produced
R3170 T3863 T3868 punct ",",produced
R3171 T3864 T3868 nsubj BMDC,produced
R3172 T3865 T3864 prep from,BMDC
R3173 T3866 T3867 compound cpdm,mice
R3174 T3867 T3865 pobj mice,from
R3175 T3868 T3868 ROOT produced,produced
R3176 T3869 T3870 advmod significantly,less
R3177 T3870 T3868 dobj less,produced
R3178 T3871 T3870 prep of,less
R3179 T3872 T3874 det all,cytokines
R3180 T3873 T3874 nummod three,cytokines
R3181 T3874 T3871 pobj cytokines,of
R3182 T3875 T3870 prep compared,less
R3183 T3876 T3875 prep with,compared
R3184 T3877 T3878 compound WT,BMDC
R3185 T3878 T3876 pobj BMDC,with
R3186 T3879 T3878 punct (,BMDC
R3187 T3880 T3881 compound Fig.,3A
R3188 T3881 T3878 appos 3A,BMDC
R3189 T3882 T3878 conj C,BMDC
R3190 T3883 T3882 punct ",",C
R3191 T3884 T3885 compound E,F
R3192 T3885 T3882 appos F,C
R3193 T3886 T3882 punct ),C
R3194 T3887 T3868 punct .,produced
R3195 T3888 T3889 det The,amount
R3196 T3889 T3897 nsubj amount,was
R3197 T3890 T3889 prep of,amount
R3198 T3891 T3892 amod nitric,oxide
R3199 T3892 T3890 pobj oxide,of
R3200 T3893 T3892 acl generated,oxide
R3201 T3894 T3893 agent by,generated
R3202 T3895 T3896 amod mutant,BMDC
R3203 T3896 T3894 pobj BMDC,by
R3204 T3897 T3897 ROOT was,was
R3205 T3898 T3897 advmod also,was
R3206 T3899 T3900 advmod significantly,reduced
R3207 T3900 T3897 acomp reduced,was
R3208 T3901 T3900 prep compared,reduced
R3209 T3902 T3901 prep with,compared
R3210 T3903 T3904 compound WT,cells
R3211 T3904 T3902 pobj cells,with
R3212 T3905 T3907 punct (,3D
R3213 T3906 T3907 compound Fig.,3D
R3214 T3907 T3904 appos 3D,cells
R3215 T3908 T3900 punct ),reduced
R3216 T3909 T3897 punct ",",was
R3217 T3910 T3897 advcl indicating,was
R3218 T3911 T3912 advmod severely,disrupted
R3219 T3912 T3913 amod disrupted,production
R3220 T3913 T3910 dobj production,indicating
R3221 T3914 T3913 prep of,production
R3222 T3915 T3916 amod proinflammatory,mediators
R3223 T3916 T3914 pobj mediators,of
R3224 T3917 T3913 prep from,production
R3225 T3918 T3919 compound Sharpin-deficient,BMDC
R3226 T3919 T3917 pobj BMDC,from
R3227 T3920 T3897 punct .,was
R3228 T3921 T3929 prep In,reversed
R3229 T3922 T3923 compound vivo,complementation
R3230 T3923 T3921 pobj complementation,In
R3231 T3924 T3923 prep with,complementation
R3232 T3925 T3928 det a,BAC
R3233 T3926 T3928 compound Sharpin,BAC
R3234 T3927 T3928 compound gene-containing,BAC
R3235 T3928 T3924 pobj BAC,with
R3236 T3929 T3929 ROOT reversed,reversed
R3237 T3930 T3931 det the,phenotype
R3238 T3931 T3929 dobj phenotype,reversed
R3239 T3932 T3931 prep of,phenotype
R3240 T3933 T3935 det the,mice
R3241 T3934 T3935 amod mutant,mice
R3242 T3935 T3932 pobj mice,of
R3243 T3936 T3938 nmod [,]
R3244 T3937 T3938 nummod 2,]
R3245 T3938 T3947 nsubj ],secreted
R3246 T3939 T3938 punct ",",]
R3247 T3940 T3938 cc and,]
R3248 T3941 T3938 conj BMDC,]
R3249 T3942 T3938 acl generated,]
R3250 T3943 T3942 prep from,generated
R3251 T3944 T3946 det these,mice
R3252 T3945 T3946 amod rescued,mice
R3253 T3946 T3943 pobj mice,from
R3254 T3947 T3929 conj secreted,reversed
R3255 T3948 T3949 advmod significantly,more
R3256 T3949 T3950 advmod more,IL12P70
R3257 T3950 T3947 dobj IL12P70,secreted
R3258 T3951 T3950 prep than,IL12P70
R3259 T3952 T3951 pobj BMDC,than
R3260 T3953 T3952 prep from,BMDC
R3261 T3954 T3955 compound cpdm,mice
R3262 T3955 T3953 pobj mice,from
R3263 T3956 T3952 punct (,BMDC
R3264 T3957 T3958 compound Fig.,3G
R3265 T3958 T3952 appos 3G,BMDC
R3266 T3959 T3952 punct ),BMDC
R3267 T3960 T3947 punct ",",secreted
R3268 T3961 T3947 advcl supporting,secreted
R3269 T3962 T3964 det a,role
R3270 T3963 T3964 amod necessary,role
R3271 T3964 T3961 dobj role,supporting
R3272 T3965 T3964 prep of,role
R3273 T3966 T3965 pobj SHARPIN,of
R3274 T3967 T3964 prep for,role
R3275 T3968 T3969 det the,production
R3276 T3969 T3967 pobj production,for
R3277 T3970 T3969 prep of,production
R3278 T3971 T3970 pobj IL12P70,of
R3279 T3972 T3947 punct .,secreted
R3280 T3973 T3992 prep In,examined
R3281 T3974 T3973 pobj addition,In
R3282 T3975 T3992 punct ",",examined
R3283 T3976 T3978 det the,levels
R3284 T3977 T3978 compound transcript,levels
R3285 T3978 T3992 nsubjpass levels,examined
R3286 T3979 T3978 prep of,levels
R3287 T3980 T3983 det the,Il6
R3288 T3981 T3982 amod inflammatory,cytokines
R3289 T3982 T3983 compound cytokines,Il6
R3290 T3983 T3979 pobj Il6,of
R3291 T3984 T3983 punct ",",Il6
R3292 T3985 T3983 conj Il12p40,Il6
R3293 T3986 T3985 punct ",",Il12p40
R3294 T3987 T3985 conj Gmcsf,Il12p40
R3295 T3988 T3987 punct ",",Gmcsf
R3296 T3989 T3987 cc and,Gmcsf
R3297 T3990 T3987 conj Ifnb,Gmcsf
R3298 T3991 T3992 auxpass were,examined
R3299 T3992 T3992 ROOT examined,examined
R3300 T3993 T3992 punct ",",examined
R3301 T3994 T3992 cc and,examined
R3302 T3995 T3996 nsubj these,were
R3303 T3996 T3999 auxpass were,reduced
R3304 T3997 T3999 dep all,reduced
R3305 T3998 T3999 advmod significantly,reduced
R3306 T3999 T3992 conj reduced,examined
R3307 T4000 T3999 prep in,reduced
R3308 T4001 T4003 amod stimulated,BMDC
R3309 T4002 T4003 compound cpdm,BMDC
R3310 T4003 T4000 pobj BMDC,in
R3311 T4004 T4005 advmod when,compared
R3312 T4005 T3999 advcl compared,reduced
R3313 T4006 T4005 prep with,compared
R3314 T4007 T4008 compound WT,controls
R3315 T4008 T4006 pobj controls,with
R3316 T4009 T4010 punct (,Fig.
R3317 T4010 T4008 parataxis Fig.,controls
R3318 T4011 T4010 nummod 4,Fig.
R3319 T4012 T4010 punct ),Fig.
R3320 T4013 T3992 punct .,examined
R11498 T13813 T13814 amod Defective,production
R11499 T13814 T13814 ROOT production,production
R11500 T13815 T13814 prep of,production
R11501 T13816 T13817 amod pro-inflammatory,mediators
R11502 T13817 T13815 pobj mediators,of
R11503 T13818 T13814 prep from,production
R11504 T13819 T13820 amod stimulated,cpdm
R11505 T13820 T13821 compound cpdm,BMDC
R11506 T13821 T13818 pobj BMDC,from
R11507 T13822 T13814 punct .,production
R11508 T13823 T13844 punct (,washed
R11509 T13824 T13844 intj A,washed
R11510 T13825 T13844 meta D,washed
R11511 T13826 T13825 punct ),D
R11512 T13827 T13828 compound Cultured,WT
R11513 T13828 T13825 conj WT,D
R11514 T13829 T13828 cc and,WT
R11515 T13830 T13831 compound cpdm,BMDC
R11516 T13831 T13828 conj BMDC,WT
R11517 T13832 T13833 punct (,1
R11518 T13833 T13836 nummod 1,cells
R11519 T13834 T13836 nummod ×,cells
R11520 T13835 T13836 nummod 105,cells
R11521 T13836 T13844 nsubjpass cells,washed
R11522 T13837 T13836 prep in,cells
R11523 T13838 T13841 nummod 0.1,medium
R11524 T13839 T13841 amod ml,medium
R11525 T13840 T13841 amod complete,medium
R11526 T13841 T13837 pobj medium,in
R11527 T13842 T13844 punct ),washed
R11528 T13843 T13844 auxpass were,washed
R11529 T13844 T13844 ROOT washed,washed
R11530 T13845 T13844 cc and,washed
R11531 T13846 T13844 conj stimulated,washed
R11532 T13847 T13846 prep with,stimulated
R11533 T13848 T13847 pobj medium,with
R11534 T13849 T13848 punct ",",medium
R11535 T13850 T13852 nummod 100,LPS
R11536 T13851 T13852 compound ng/ml,LPS
R11537 T13852 T13848 conj LPS,medium
R11538 T13853 T13852 cc or,LPS
R11539 T13854 T13858 nummod 25,poly
R11540 T13855 T13858 nmod µg,poly
R11541 T13856 T13858 nmod /,poly
R11542 T13857 T13858 compound ml,poly
R11543 T13858 T13852 conj poly,LPS
R11544 T13859 T13858 nummod I,poly
R11545 T13860 T13858 punct :,poly
R11546 T13861 T13858 appos C,poly
R11547 T13862 T13852 prep for,LPS
R11548 T13863 T13864 nummod 24,hours
R11549 T13864 T13862 pobj hours,for
R11550 T13865 T13844 punct .,washed
R11551 T13866 T13868 nsubjpass Supernatants,collected
R11552 T13867 T13868 auxpass were,collected
R11553 T13868 T13868 ROOT collected,collected
R11554 T13869 T13868 prep for,collected
R11555 T13870 T13869 pobj ELISA,for
R11556 T13871 T13870 prep of,ELISA
R11557 T13872 T13871 pobj IL12P70,of
R11558 T13873 T13872 punct ",",IL12P70
R11559 T13874 T13872 conj IL6,IL12P70
R11560 T13875 T13874 punct ",",IL6
R11561 T13876 T13874 cc and,IL6
R11562 T13877 T13874 conj GMCSF,IL6
R11563 T13878 T13877 punct ",",GMCSF
R11564 T13879 T13869 cc and,for
R11565 T13880 T13869 conj for,for
R11566 T13881 T13880 pobj quantification,for
R11567 T13882 T13881 prep of,quantification
R11568 T13883 T13884 amod nitric,oxide
R11569 T13884 T13882 pobj oxide,of
R11570 T13885 T13884 punct (,oxide
R11571 T13886 T13880 intj NO,for
R11572 T13887 T13880 punct ),for
R11573 T13888 T13868 punct .,collected
R11574 T13889 T13891 punct (,F
R11575 T13890 T13891 compound E,F
R11576 T13891 T13891 ROOT F,F
R11577 T13892 T13891 punct ),F
R11578 T13893 T13894 compound Gradient,numbers
R11579 T13894 T13918 nsubjpass numbers,used
R11580 T13895 T13896 punct (,1
R11581 T13896 T13918 meta 1,used
R11582 T13897 T13898 nummod ×,104
R11583 T13898 T13896 appos 104,1
R11584 T13899 T13902 punct ",",104
R11585 T13900 T13902 nummod 2,104
R11586 T13901 T13902 nummod ×,104
R11587 T13902 T13896 appos 104,1
R11588 T13903 T13896 punct ",",1
R11589 T13904 T13896 cc and,1
R11590 T13905 T13906 nummod 4,×
R11591 T13906 T13918 nsubjpass ×,used
R11592 T13907 T13908 nummod 104,cells
R11593 T13908 T13906 appos cells,×
R11594 T13909 T13908 prep in,cells
R11595 T13910 T13913 nummod 0.1,medium
R11596 T13911 T13913 nmod mL,medium
R11597 T13912 T13913 amod complete,medium
R11598 T13913 T13909 pobj medium,in
R11599 T13914 T13908 punct ),cells
R11600 T13915 T13908 prep of,cells
R11601 T13916 T13915 pobj BMDC,of
R11602 T13917 T13918 auxpass were,used
R11603 T13918 T13918 ROOT used,used
R11604 T13919 T13922 nummod for100,stimulation
R11605 T13920 T13922 compound ng/mL,stimulation
R11606 T13921 T13922 compound LPS,stimulation
R11607 T13922 T13918 dobj stimulation,used
R11608 T13923 T13918 punct .,used
R11609 T13924 T13938 prep After,measured
R11610 T13925 T13926 nummod 24,hours
R11611 T13926 T13924 pobj hours,After
R11612 T13927 T13938 punct ",",measured
R11613 T13928 T13929 det the,amounts
R11614 T13929 T13938 nsubjpass amounts,measured
R11615 T13930 T13929 prep of,amounts
R11616 T13931 T13930 pobj IL12P70,of
R11617 T13932 T13931 cc and,IL12P70
R11618 T13933 T13931 conj IL6,IL12P70
R11619 T13934 T13929 prep from,amounts
R11620 T13935 T13936 det the,supernatant
R11621 T13936 T13934 pobj supernatant,from
R11622 T13937 T13938 auxpass were,measured
R11623 T13938 T13938 ROOT measured,measured
R11624 T13939 T13938 punct .,measured
R11625 T13940 T13941 punct (,G
R11626 T13941 T13941 ROOT G,G
R11627 T13942 T13941 punct ),G
R11628 T13943 T13945 det The,mice
R11629 T13944 T13945 compound cpdm,mice
R11630 T13945 T13950 nsubj mice,had
R11631 T13946 T13945 acl rescued,mice
R11632 T13947 T13946 agent by,rescued
R11633 T13948 T13949 amod Sharpin-containing,BAC
R11634 T13949 T13947 pobj BAC,by
R11635 T13950 T13950 ROOT had,had
R11636 T13951 T13952 amod complete,remission
R11637 T13952 T13950 dobj remission,had
R11638 T13953 T13952 prep of,remission
R11639 T13954 T13957 det the,[
R11640 T13955 T13956 amod inflammatory,phenotype
R11641 T13956 T13957 compound phenotype,[
R11642 T13957 T13953 pobj [,of
R11643 T13958 T13957 nummod 2,[
R11644 T13959 T13957 appos ],[
R11645 T13960 T13950 punct .,had
R11646 T13961 T13962 nsubj BMDC,developed
R11647 T13962 T13962 ROOT developed,developed
R11648 T13963 T13962 prep from,developed
R11649 T13964 T13963 pobj cpdm,from
R11650 T13965 T13962 cc and,developed
R11651 T13966 T13962 conj rescued,developed
R11652 T13967 T13968 compound cpdm,mice
R11653 T13968 T13970 nsubjpass mice,plated
R11654 T13969 T13970 auxpass were,plated
R11655 T13970 T13966 ccomp plated,rescued
R11656 T13971 T13970 punct (,plated
R11657 T13972 T13975 nummod 1,cells
R11658 T13973 T13975 nummod ×,cells
R11659 T13974 T13975 nummod 106,cells
R11660 T13975 T13970 appos cells,plated
R11661 T13976 T13975 prep in,cells
R11662 T13977 T13978 nummod 0.3,mL
R11663 T13978 T13976 pobj mL,in
R11664 T13979 T13975 punct ),cells
R11665 T13980 T13970 cc and,plated
R11666 T13981 T13970 conj stimulated,plated
R11667 T13982 T13981 prep with,stimulated
R11668 T13983 T13985 nummod 100,LPS
R11669 T13984 T13985 compound ng/mL,LPS
R11670 T13985 T13982 pobj LPS,with
R11671 T13986 T13962 punct .,developed
R11672 T13987 T13993 prep After,collected
R11673 T13988 T13989 nummod 24,hours
R11674 T13989 T13987 pobj hours,After
R11675 T13990 T13993 punct ",",collected
R11949 T14307 T14309 nmod /,poly
R11950 T14308 T14309 compound ml,poly
R11951 T14309 T14310 nmod poly,I
R11952 T14310 T14294 nummod I,LPS
R11953 T14311 T14312 punct :,C
R11954 T14312 T14310 acl C,I
R11955 T14313 T14314 punct (,B
R11956 T14314 T14312 appos B,C
R11957 T14315 T14314 punct ",",B
R11958 T14316 T14314 appos D,B
R11959 T14317 T14316 punct ",",D
R11960 T14318 T14316 appos F,D
R11961 T14319 T14316 punct ",",D
R11962 T14320 T14316 appos H,D
R11963 T14321 T14314 punct ),B
R11964 T14322 T14288 punct .,washed
R11965 T14323 T14334 prep At,extracted
R11966 T14324 T14323 pobj 0,At
R11967 T14325 T14334 punct ",",extracted
R11968 T14326 T14329 nummod 1,hours
R11969 T14327 T14326 cc and,1
R11970 T14328 T14326 conj 2,1
R11971 T14329 T14334 npadvmod hours,extracted
R11972 T14330 T14334 punct ",",extracted
R11973 T14331 T14332 amod total,RNA
R11974 T14332 T14334 nsubjpass RNA,extracted
R11975 T14333 T14334 auxpass was,extracted
R11976 T14334 T14334 ROOT extracted,extracted
R11977 T14335 T14334 cc and,extracted
R11978 T14336 T14372 nmod subject,mRNA
R11979 T14337 T14336 prep to,subject
R11980 T14338 T14337 pobj qRT-PCR,to
R11981 T14339 T14340 aux to,measure
R11982 T14340 T14336 xcomp measure,subject
R11983 T14341 T14342 det the,expression
R11984 T14342 T14340 dobj expression,measure
R11985 T14343 T14342 prep of,expression
R11986 T14344 T14343 pobj Il12p40,of
R11987 T14345 T14346 punct (,A
R11988 T14346 T14348 advmod A,B
R11989 T14347 T14346 punct ",",A
R11990 T14348 T14344 appos B,Il12p40
R11991 T14349 T14344 punct ),Il12p40
R11992 T14350 T14344 punct ",",Il12p40
R11993 T14351 T14344 conj Il6,Il12p40
R11994 T14352 T14353 punct (,C
R11995 T14353 T14344 appos C,Il12p40
R11692 T14007 T14001 punct .,are
R11693 T14008 T14016 ccomp *,0.005
R11694 T14009 T14011 nmod P,0.01
R11695 T14010 T14011 compound <,0.01
R11696 T14011 T14008 npadvmod 0.01,*
R11697 T14012 T14016 punct ;,0.005
R11698 T14013 T14016 punct **,0.005
R11699 T14014 T14015 nmod P,<
R11700 T14015 T14016 nmod <,0.005
R11701 T14016 T14016 ROOT 0.005,0.005
R11702 T14017 T14016 punct .,0.005
R11903 T14261 T14263 amod Decreased,levels
R11904 T14262 T14263 compound mRNA,levels
R11905 T14263 T14263 ROOT levels,levels
R11906 T14264 T14263 prep of,levels
R11907 T14265 T14266 amod inflammatory,cytokines
R11908 T14266 T14264 pobj cytokines,of
R11909 T14267 T14263 prep from,levels
R11910 T14268 T14269 compound cpdm,BMDC
R11911 T14269 T14267 pobj BMDC,from
R11912 T14270 T14263 punct .,levels
R11913 T14271 T14272 compound Cultured,WT
R11676 T13991 T13993 nsubjpass supernatants,collected
R11677 T13992 T13993 auxpass were,collected
R11678 T13993 T13993 ROOT collected,collected
R11679 T13994 T13993 prep for,collected
R11680 T13995 T13994 pobj analysis,for
R11681 T13996 T13995 prep of,analysis
R11682 T13997 T13998 compound IL12P70,production
R11683 T13998 T13996 pobj production,of
R11684 T13999 T13993 punct .,collected
R11685 T14000 T14001 nsubj Data,are
R11686 T14001 T14001 ROOT are,are
R11687 T14002 T14001 attr representative,are
R11688 T14003 T14002 prep of,representative
R11689 T14004 T14006 nummod three,experiments
R11690 T14005 T14006 amod independent,experiments
R11691 T14006 T14003 pobj experiments,of
R11914 T14272 T14288 nsubjpass WT,washed
R11915 T14273 T14272 cc and,WT
R11916 T14274 T14275 compound cpdm,BMDC
R11917 T14275 T14272 conj BMDC,WT
R11918 T14276 T14277 punct (,5
R11919 T14277 T14280 nummod 5,cells
R11920 T14278 T14280 nummod ×,cells
R11921 T14279 T14280 nummod 105,cells
R11922 T14280 T14272 appos cells,WT
R11923 T14281 T14280 prep in,cells
R11924 T14282 T14283 nummod 0.2,ml
R11925 T14283 T14285 nmod ml,medium
R11926 T14284 T14285 amod complete,medium
R11927 T14285 T14281 pobj medium,in
R11928 T14286 T14280 punct ),cells
R11929 T14287 T14288 auxpass were,washed
R11930 T14288 T14288 ROOT washed,washed
R11931 T14289 T14288 cc and,washed
R11932 T14290 T14288 conj stimulated,washed
R11933 T14291 T14290 prep with,stimulated
R11934 T14292 T14294 nummod 100,LPS
R11935 T14293 T14294 amod ng/ml,LPS
R11936 T14294 T14291 pobj LPS,with
R11937 T14295 T14298 punct (,C
R11938 T14296 T14298 nmod A,C
R11939 T14297 T14298 punct ",",C
R11940 T14298 T14294 appos C,LPS
R11941 T14299 T14298 punct ",",C
R11942 T14300 T14298 conj E,C
R11943 T14301 T14300 punct ",",E
R11944 T14302 T14300 conj G,E
R11945 T14303 T14300 punct ),E
R11946 T14304 T14298 cc or,C
R11947 T14305 T14298 nummod 25,C
R11948 T14306 T14309 nmod µg,poly
R11996 T14354 T14353 punct ",",C
R11997 T14355 T14353 appos D,C
R11998 T14356 T14353 punct ),C
R11999 T14357 T14353 punct ",",C
R12000 T14358 T14343 pobj Gmcsf,of
R12001 T14359 T14360 punct (,E
R12002 T14360 T14358 appos E,Gmcsf
R12003 T14361 T14358 punct ",",Gmcsf
R12004 T14362 T14358 appos F,Gmcsf
R12005 T14363 T14358 punct ),Gmcsf
R12006 T14364 T14336 punct ",",subject
R12007 T14365 T14336 cc and,subject
R12008 T14366 T14336 conj Ifnb,subject
R12009 T14367 T14368 punct (,G
R12010 T14368 T14372 nmod G,mRNA
R12011 T14369 T14368 punct ",",G
R12012 T14370 T14368 appos H,G
R12013 T14371 T14372 punct ),mRNA
R12014 T14372 T14334 conj mRNA,extracted
R12015 T14373 T14334 punct .,extracted
R12016 T14374 T14375 nsubj Bars,represent
R12017 T14375 T14375 ROOT represent,represent
R12018 T14376 T14378 amod mean,SD
R12019 T14377 T14378 compound ±,SD
R12020 T14378 T14375 dobj SD,represent
R12021 T14379 T14375 punct .,represent
R12022 T14380 T14381 nsubj Data,are
R12023 T14381 T14381 ROOT are,are
R12024 T14382 T14381 attr representative,are
R12025 T14383 T14382 prep of,representative
R12026 T14384 T14386 nummod two,experiments
R12027 T14385 T14386 amod independent,experiments
R12028 T14386 T14383 pobj experiments,of
R12029 T14387 T14381 punct .,are

GO-BP

Id Subject Object Predicate Lexical cue
T4209 109-118 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T14210 1392-1408 http://purl.obolibrary.org/obo/GO_0051410 denotes nitric oxide (NO

GO-CC

Id Subject Object Predicate Lexical cue
T4210 394-399 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T14211 1178-1183 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T14212 1459-1464 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T14213 1799-1804 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T14513 2152-2157 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T3823 0-64 Sentence denotes Production of proinflammatory mediators by cpdm BMDC is impaired
T3824 65-293 Sentence denotes Incubation with LPS or poly I:C resulted in secretion of IL6, IL12P70, and GMCSF from both WT and cpdm BMDC; however, BMDC from cpdm mice produced significantly less of all three cytokines compared with WT BMDC (Fig. 3A–C, E–F).
T3825 294-509 Sentence denotes The amount of nitric oxide generated by mutant BMDC was also significantly reduced compared with WT cells (Fig. 3D), indicating severely disrupted production of proinflammatory mediators from Sharpin-deficient BMDC.
T3826 510-800 Sentence denotes In vivo complementation with a Sharpin gene-containing BAC reversed the phenotype of the mutant mice [2], and BMDC generated from these rescued mice secreted significantly more IL12P70 than BMDC from cpdm mice (Fig. 3G), supporting a necessary role of SHARPIN for the production of IL12P70.
T3827 801-1016 Sentence denotes In addition, the transcript levels of the inflammatory cytokines Il6, Il12p40, Gmcsf, and Ifnb were examined, and these were all significantly reduced in stimulated cpdm BMDC when compared with WT controls (Fig. 4).
T13806 1061-1138 Sentence denotes Defective production of pro-inflammatory mediators from stimulated cpdm BMDC.
T13807 1139-1299 Sentence denotes (A–D) Cultured WT and cpdm BMDC (1×105 cells in 0.1 ml complete medium) were washed and stimulated with medium, 100 ng/ml LPS or 25 µg/ml poly I:C for 24 hours.
T13808 1300-1539 Sentence denotes Supernatants were collected for ELISA of IL12P70, IL6, and GMCSF, and for quantification of nitric oxide (NO). (E–F) Gradient numbers (1×104, 2×104, and 4×104 cells in 0.1 mL complete medium) of BMDC were used for100 ng/mL LPS stimulation.
T13809 1540-1732 Sentence denotes After 24 hours, the amounts of IL12P70 and IL6 from the supernatant were measured. (G) The cpdm mice rescued by Sharpin-containing BAC had complete remission of the inflammatory phenotype [2].
T13810 1733-1850 Sentence denotes BMDC developed from cpdm and rescued cpdm mice were plated (1×106 cells in 0.3 mL) and stimulated with 100 ng/mL LPS.
T13811 1851-1930 Sentence denotes After 24 hours, supernatants were collected for analysis of IL12P70 production.
T13812 1931-2010 Sentence denotes Data are representative of three independent experiments. * P<0.01; ** P<0.005.
T14256 2055-2118 Sentence denotes Decreased mRNA levels of inflammatory cytokines from cpdm BMDC.
T14257 2119-2272 Sentence denotes Cultured WT and cpdm BMDC (5×105 cells in 0.2 ml complete medium) were washed and stimulated with 100 ng/ml LPS (A,C,E,G) or 25 µg/ml poly I:C (B,D,F,H).
T14258 2273-2429 Sentence denotes At 0, 1 and 2 hours, total RNA was extracted and subject to qRT-PCR to measure the expression of Il12p40 (A,B), Il6 (C,D), Gmcsf (E,F), and Ifnb (G,H) mRNA.
T14259 2430-2455 Sentence denotes Bars represent mean ± SD.
T14260 2456-2511 Sentence denotes Data are representative of two independent experiments.
T72 0-64 Sentence denotes Production of proinflammatory mediators by cpdm BMDC is impaired
T73 65-293 Sentence denotes Incubation with LPS or poly I:C resulted in secretion of IL6, IL12P70, and GMCSF from both WT and cpdm BMDC; however, BMDC from cpdm mice produced significantly less of all three cytokines compared with WT BMDC (Fig. 3A–C, E–F).
T74 294-509 Sentence denotes The amount of nitric oxide generated by mutant BMDC was also significantly reduced compared with WT cells (Fig. 3D), indicating severely disrupted production of proinflammatory mediators from Sharpin-deficient BMDC.
T75 510-800 Sentence denotes In vivo complementation with a Sharpin gene-containing BAC reversed the phenotype of the mutant mice [2], and BMDC generated from these rescued mice secreted significantly more IL12P70 than BMDC from cpdm mice (Fig. 3G), supporting a necessary role of SHARPIN for the production of IL12P70.
T76 801-1016 Sentence denotes In addition, the transcript levels of the inflammatory cytokines Il6, Il12p40, Gmcsf, and Ifnb were examined, and these were all significantly reduced in stimulated cpdm BMDC when compared with WT controls (Fig. 4).
T77 1017-1138 Sentence denotes 10.1371/journal.pone.0031809.g003 Figure 3 Defective production of pro-inflammatory mediators from stimulated cpdm BMDC.
T78 1139-1299 Sentence denotes (A–D) Cultured WT and cpdm BMDC (1×105 cells in 0.1 ml complete medium) were washed and stimulated with medium, 100 ng/ml LPS or 25 µg/ml poly I:C for 24 hours.
T79 1300-1539 Sentence denotes Supernatants were collected for ELISA of IL12P70, IL6, and GMCSF, and for quantification of nitric oxide (NO). (E–F) Gradient numbers (1×104, 2×104, and 4×104 cells in 0.1 mL complete medium) of BMDC were used for100 ng/mL LPS stimulation.
T80 1540-1732 Sentence denotes After 24 hours, the amounts of IL12P70 and IL6 from the supernatant were measured. (G) The cpdm mice rescued by Sharpin-containing BAC had complete remission of the inflammatory phenotype [2].
T81 1733-1850 Sentence denotes BMDC developed from cpdm and rescued cpdm mice were plated (1×106 cells in 0.3 mL) and stimulated with 100 ng/mL LPS.
T82 1851-1930 Sentence denotes After 24 hours, supernatants were collected for analysis of IL12P70 production.
T83 1931-2010 Sentence denotes Data are representative of three independent experiments. * P<0.01; ** P<0.005.
T84 2011-2118 Sentence denotes 10.1371/journal.pone.0031809.g004 Figure 4 Decreased mRNA levels of inflammatory cytokines from cpdm BMDC.
T85 2119-2272 Sentence denotes Cultured WT and cpdm BMDC (5×105 cells in 0.2 ml complete medium) were washed and stimulated with 100 ng/ml LPS (A,C,E,G) or 25 µg/ml poly I:C (B,D,F,H).
T86 2273-2429 Sentence denotes At 0, 1 and 2 hours, total RNA was extracted and subject to qRT-PCR to measure the expression of Il12p40 (A,B), Il6 (C,D), Gmcsf (E,F), and Ifnb (G,H) mRNA.
T87 2430-2455 Sentence denotes Bars represent mean ± SD.
T88 2456-2511 Sentence denotes Data are representative of two independent experiments.

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T4247 97-105 Positive_regulation denotes resulted
T4248 97-105 Positive_regulation denotes resulted
T4249 109-118 Gene_expression denotes secretion
T4250 109-118 Gene_expression denotes secretion
T4251 122-125 Protein denotes IL6
T4252 140-145 Protein denotes GMCSF
T4253 203-211 Gene_expression denotes produced
T4254 203-211 Gene_expression denotes produced
T4255 226-230 Positive_regulation denotes less true
T4256 226-230 Positive_regulation denotes less true
T4257 486-493 Protein denotes Sharpin
T4258 494-503 Negative_regulation denotes deficient
T4259 541-548 Protein denotes Sharpin
T4260 762-769 Protein denotes SHARPIN
T4261 866-869 Protein denotes Il6
T4262 871-878 Protein denotes Il12p40
T4263 880-885 Protein denotes Gmcsf
T4264 891-895 Protein denotes Ifnb
T14222 1350-1353 Protein denotes IL6
T14223 1359-1364 Protein denotes GMCSF
T14224 1583-1586 Protein denotes IL6
T14225 1652-1659 Protein denotes Sharpin
T14530 2356-2366 Transcription denotes expression true
T14531 2356-2366 Transcription denotes expression true
T14532 2356-2366 Transcription denotes expression true
T14533 2356-2366 Transcription denotes expression true
T14534 2370-2377 Protein denotes Il12p40
T14535 2385-2388 Protein denotes Il6
T14536 2396-2401 Protein denotes Gmcsf
T14537 2413-2417 Protein denotes Ifnb
R3521 T4249 T4248 themeOf secretion,resulted
R3522 T4250 T4247 themeOf secretion,resulted
R3523 T4251 T4250 themeOf IL6,secretion
R3524 T4251 T4253 themeOf IL6,produced
R3525 T4252 T4249 themeOf GMCSF,secretion
R3526 T4252 T4254 themeOf GMCSF,produced
R3527 T4253 T4255 themeOf produced,less
R3528 T4254 T4256 themeOf produced,less
R3529 T4257 T4258 themeOf Sharpin,deficient
R12159 T14534 T14533 themeOf Il12p40,expression
R12160 T14535 T14532 themeOf Il6,expression
R12161 T14536 T14531 themeOf Gmcsf,expression
R12162 T14537 T14530 themeOf Ifnb,expression

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T4265 122-125 Protein denotes IL6
T4266 127-134 Protein denotes IL12P70
T4267 140-145 Protein denotes GMCSF
T4268 268-275 Protein denotes WT BMDC
T4269 277-280 Protein denotes Fig
T4270 109-118 Localization denotes secretion
T4271 109-118 Localization denotes secretion
T4272 109-118 Localization denotes secretion
T4273 203-211 Gene_expression denotes produced
T4274 203-211 Gene_expression denotes produced
T4275 97-105 Positive_regulation denotes resulted
T4276 97-105 Positive_regulation denotes resulted
T4277 97-105 Positive_regulation denotes resulted
T4278 486-493 Protein denotes Sharpin
T4279 494-503 Negative_regulation denotes deficient
T4280 541-548 Protein denotes Sharpin
T4281 687-694 Protein denotes IL12P70
T4282 762-769 Protein denotes SHARPIN
T4283 792-799 Protein denotes IL12P70
T4284 659-667 Localization denotes secreted
T4285 778-788 Gene_expression denotes production
T4286 754-758 Positive_regulation denotes role
T4287 856-869 Protein denotes cytokines Il6
T4288 871-878 Protein denotes Il12p40
T4289 829-835 Transcription denotes levels
T4290 829-835 Transcription denotes levels
T4291 944-951 Negative_regulation denotes reduced
T4292 944-951 Negative_regulation denotes reduced
T14226 1341-1348 Protein denotes IL12P70
T14227 1350-1353 Protein denotes IL6
T14228 1359-1364 Protein denotes GMCSF
T14229 1571-1578 Protein denotes IL12P70
T14230 1583-1586 Protein denotes IL6
T14231 1652-1674 Protein denotes Sharpin-containing BAC
T14232 1911-1918 Protein denotes IL12P70
T14233 1919-1929 Gene_expression denotes production
T14538 2333-2336 Protein denotes qRT
R3530 T4265 T4270 themeOf IL6,secretion
R3531 T4266 T4271 themeOf IL12P70,secretion
R3532 T4267 T4272 themeOf GMCSF,secretion
R3533 T4268 T4273 themeOf WT BMDC,produced
R3534 T4269 T4274 themeOf Fig,produced
R3535 T4270 T4275 themeOf secretion,resulted
R3536 T4271 T4276 themeOf secretion,resulted
R3537 T4272 T4277 themeOf secretion,resulted
R3538 T4278 T4279 themeOf Sharpin,deficient
R3539 T4281 T4284 themeOf IL12P70,secreted
R3540 T4282 T4286 causeOf SHARPIN,role
R3541 T4283 T4285 themeOf IL12P70,production
R3542 T4285 T4286 themeOf production,role
R3543 T4287 T4289 themeOf cytokines Il6,levels
R3544 T4288 T4290 themeOf Il12p40,levels
R3545 T4289 T4291 themeOf levels,reduced
R3546 T4290 T4292 themeOf levels,reduced
R11889 T14232 T14233 themeOf IL12P70,production

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T14248 2356-2366 Transcription denotes expression true
T14249 2356-2366 Transcription denotes expression true
T14250 2356-2366 Transcription denotes expression true
T14251 2356-2366 Transcription denotes expression true
T14252 2370-2377 Protein denotes Il12p40
T14253 2385-2388 Protein denotes Il6
T14254 2396-2401 Protein denotes Gmcsf
T14255 2413-2417 Protein denotes Ifnb
T13802 1350-1353 Protein denotes IL6
T13803 1359-1364 Protein denotes GMCSF
T13804 1583-1586 Protein denotes IL6
T13805 1652-1659 Protein denotes Sharpin
T3805 97-105 Positive_regulation denotes resulted
T3806 97-105 Positive_regulation denotes resulted
T3807 109-118 Gene_expression denotes secretion
T3808 109-118 Gene_expression denotes secretion
T3809 122-125 Protein denotes IL6
T3810 140-145 Protein denotes GMCSF
T3811 203-211 Gene_expression denotes produced
T3812 203-211 Gene_expression denotes produced
T3813 226-230 Positive_regulation denotes less true
T3814 226-230 Positive_regulation denotes less true
T3815 486-493 Protein denotes Sharpin
T3816 494-503 Negative_regulation denotes deficient
T3817 541-548 Protein denotes Sharpin
T3818 762-769 Protein denotes SHARPIN
T3819 866-869 Protein denotes Il6
T3820 871-878 Protein denotes Il12p40
T3821 880-885 Protein denotes Gmcsf
T3822 891-895 Protein denotes Ifnb
R11899 T14252 T14251 themeOf Il12p40,expression
R11900 T14253 T14250 themeOf Il6,expression
R11901 T14254 T14249 themeOf Gmcsf,expression
R11902 T14255 T14248 themeOf Ifnb,expression
R3126 T3807 T3806 themeOf secretion,resulted
R3127 T3808 T3805 themeOf secretion,resulted
R3128 T3809 T3808 themeOf IL6,secretion
R3129 T3809 T3811 themeOf IL6,produced
R3130 T3810 T3807 themeOf GMCSF,secretion
R3131 T3810 T3812 themeOf GMCSF,produced
R3132 T3811 T3813 themeOf produced,less
R3133 T3812 T3814 themeOf produced,less
R3134 T3815 T3816 themeOf Sharpin,deficient

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T14199 1350-1353 P05231 denotes IL6
T14200 1359-1364 P04141 denotes GMCSF
T14201 1583-1586 P05231 denotes IL6
T14202 1652-1659 Q9H0F6 denotes Sharpin
T14506 2385-2388 P05231 denotes Il6
T14507 2396-2401 P04141 denotes Gmcsf
T4197 122-125 P05231 denotes IL6
T4198 140-145 P04141 denotes GMCSF
T4199 486-493 Q9H0F6 denotes Sharpin
T4200 541-548 Q9H0F6 denotes Sharpin
T4201 762-769 Q9H0F6 denotes SHARPIN
T4202 866-869 P05231 denotes Il6
T4203 880-885 P04141 denotes Gmcsf

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T3791 56-64 Negative_regulation denotes impaired
T3792 97-105 Positive_regulation denotes resulted
T3793 109-118 Gene_expression denotes secretion
T3794 122-125 Protein denotes IL6
T3795 140-145 Protein denotes GMCSF
T3796 486-493 Protein denotes Sharpin
T3797 494-503 Negative_regulation denotes deficient true
T3798 541-548 Protein denotes Sharpin true
T3799 754-758 Regulation denotes role
T3800 762-769 Protein denotes SHARPIN
T3801 866-869 Protein denotes Il6
T3802 871-878 Protein denotes Il12p40
T3803 880-885 Protein denotes Gmcsf
T3804 891-895 Protein denotes Ifnb
T13798 1350-1353 Protein denotes IL6
T13799 1359-1364 Protein denotes GMCSF
T13800 1583-1586 Protein denotes IL6
T13801 1652-1659 Protein denotes Sharpin
T14242 2344-2351 Regulation denotes measure true
T14243 2356-2366 Gene_expression denotes expression true
T14244 2370-2377 Protein denotes Il12p40 true
T14245 2385-2388 Protein denotes Il6 true
T14246 2396-2401 Protein denotes Gmcsf
T14247 2413-2417 Protein denotes Ifnb
R3122 T3793 T3792 themeOf secretion,resulted
R3123 T3794 T3793 themeOf IL6,secretion
R3124 T3795 T3793 themeOf GMCSF,secretion
R3125 T3796 T3797 themeOf Sharpin,deficient
R11894 T14243 T14242 themeOf expression,measure
R11895 T14244 T14243 themeOf Il12p40,expression
R11896 T14245 T14243 themeOf Il6,expression
R11897 T14246 T14243 themeOf Gmcsf,expression
R11898 T14247 T14243 themeOf Ifnb,expression