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{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/3248852","sourcedb":"PMC","sourceid":"3248852","source_url":"http://www.ncbi.nlm.nih.gov/pmc/3248852","text":"Background\nProgesterone triggers resumption of the first meiotic division in the Rana pipiens oocyte by binding to the N-terminal external loop of the catalytic subunit of Na/K-ATPase, releasing a cascade of lipid second messengers. This is followed by internalization of specific membrane proteins, plasma membrane depolarization and nuclear membrane breakdown, culminating in arrest at second metaphase.","divisions":[{"label":"Title","span":{"begin":0,"end":10}}],"tracks":[]}