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PMC:3245220 / 32411-40103 JSONTXT

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bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T16913 212-215 P19838 denotes p50
T16914 216-219 Q04206 denotes p65
T16915 216-219 P21579 denotes p65
T16916 703-708 P09603 denotes M-CSF
T16917 705-708 P04141 denotes CSF
T16918 853-858 P09603 denotes M-CSF
T16919 855-858 P04141 denotes CSF
T16920 870-874 P17252 denotes PKCα
T16921 1046-1050 P17252 denotes PKCα
T16922 1054-1058 P17252 denotes PKCα
T16923 1073-1078 P09603 denotes M-CSF
T16924 1075-1078 P04141 denotes CSF
T16925 1180-1185 P09603 denotes M-CSF
T16926 1182-1185 P04141 denotes CSF
T16927 1219-1222 P21579 denotes p65
T16928 1219-1222 Q04206 denotes p65
T16929 1287-1291 P17252 denotes PKCα
T16930 1324-1327 P21579 denotes p65
T16931 1324-1327 Q04206 denotes p65
T16932 1430-1435 P09603 denotes M-CSF
T16933 1432-1435 P04141 denotes CSF
T16934 1524-1529 P09603 denotes M-CSF
T16935 1526-1529 P04141 denotes CSF
T16936 1590-1593 Q04206 denotes p65
T16937 1590-1593 P21579 denotes p65
T16938 1649-1652 Q04206 denotes p65
T16939 1649-1652 P21579 denotes p65
T16940 1724-1727 P21579 denotes p65
T16941 1724-1727 Q04206 denotes p65
T16942 2108-2111 Q04206 denotes p65
T16943 2108-2111 P21579 denotes p65
T16944 2219-2222 P21579 denotes p65
T16945 2219-2222 Q04206 denotes p65
T16946 2410-2413 Q04206 denotes p65
T16947 2410-2413 P21579 denotes p65
T16948 2561-2565 O75582 denotes MSK1
T16949 2632-2635 P21579 denotes p65
T16950 2632-2635 Q04206 denotes p65
T16951 2720-2724 O14920 denotes IKKβ
T16952 2845-2850 P09603 denotes M-CSF
T16953 2847-2850 P04141 denotes CSF
T16954 2899-2902 P21579 denotes p65
T16955 2899-2902 Q04206 denotes p65
T16956 2966-2970 P17252 denotes PKCα
T16957 3100-3103 Q04206 denotes p65
T16958 3100-3103 P21579 denotes p65
T16959 3168-3171 P21579 denotes p65
T16960 3168-3171 Q04206 denotes p65
T16961 3189-3192 Q04206 denotes p65
T16962 3189-3192 P21579 denotes p65
T16963 3313-3316 Q04206 denotes p65
T16964 3313-3316 P21579 denotes p65
T16965 3429-3434 P09603 denotes M-CSF
T16966 3431-3434 P04141 denotes CSF
T16967 3451-3454 P21579 denotes p65
T16968 3451-3454 Q04206 denotes p65
T16969 3514-3518 P17252 denotes PKCα
T16970 3537-3541 P17252 denotes PKCα
T16971 3671-3675 P17252 denotes PKCα
T16972 3808-3812 P17252 denotes PKCα
T16973 3870-3874 P17252 denotes PKCα
T16974 3995-3999 P17252 denotes PKCα
T16975 4012-4016 P17252 denotes PKCα
T16976 4033-4038 P09603 denotes M-CSF
T16977 4035-4038 P04141 denotes CSF
T16978 4111-4114 Q04206 denotes p65
T16979 4111-4114 P21579 denotes p65
T16980 4572-4575 Q04206 denotes p65
T16981 4572-4575 P21579 denotes p65
T16982 4791-4795 P17252 denotes PKCα
T16983 4871-4876 P09603 denotes M-CSF
T16984 4873-4876 P04141 denotes CSF
T16985 5041-5046 P09603 denotes M-CSF
T16986 5043-5046 P04141 denotes CSF
T16987 5127-5131 P17252 denotes PKCα
T16988 5385-5391 P05771 denotes PKCβII
T16989 5454-5460 P05771 denotes PKCβII
T16990 5547-5553 P05771 denotes PKCβII
T16991 5736-5739 P21579 denotes p65
T16992 5736-5739 Q04206 denotes p65
T16993 5766-5770 P25963 denotes IκBα
T16994 6071-6074 P21579 denotes p65
T16995 6071-6074 Q04206 denotes p65
T16996 6205-6209 P25963 denotes IκBα
T16997 6231-6234 P21579 denotes p65
T16998 6231-6234 Q04206 denotes p65
T16999 6268-6273 P09603 denotes M-CSF
T17000 6270-6273 P04141 denotes CSF
T17001 6284-6289 P09603 denotes M-CSF
T17002 6286-6289 P04141 denotes CSF
T17003 6323-6326 P21579 denotes p65
T17004 6323-6326 Q04206 denotes p65
T17005 6417-6421 P17252 denotes PKCα
T17006 6443-6447 P17252 denotes PKCα
T17007 6594-6599 P09603 denotes M-CSF
T17008 6596-6599 P04141 denotes CSF
T17009 6842-6845 Q00653 denotes p52
T17010 6853-6857 Q01201 denotes relB
T17011 6917-6921 Q00653 denotes p100
T17012 6963-6968 P09603 denotes M-CSF
T17013 6965-6968 P04141 denotes CSF
T17014 7126-7131 P09603 denotes M-CSF
T17015 7128-7131 P04141 denotes CSF
T17016 7140-7149 P42574 denotes caspase-3
T17017 7323-7327 P17252 denotes PKCα
T17018 7336-7341 P09603 denotes M-CSF
T17019 7338-7341 P04141 denotes CSF
T17020 7454-7459 P09603 denotes M-CSF
T17021 7456-7459 P04141 denotes CSF
T17022 7511-7514 Q04206 denotes p65
T17023 7511-7514 P21579 denotes p65
T26881 1963-1968 P09603 denotes M-CSF
T26882 1965-1968 P04141 denotes CSF
T26883 2034-2037 Q04206 denotes p65
T26884 2034-2037 P21579 denotes p65

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T17024 233-244 Localization denotes translocate
T17025 1328-1343 Phosphorylation denotes phosphorylation
T17026 1308-1317 Negative_regulation denotes inhibited true
T17027 1328-1343 Phosphorylation denotes phosphorylation
T17028 1573-1583 Positive_regulation denotes activating
T17029 1594-1609 Phosphorylation denotes phosphorylation
T17030 1652-1655 Gene_expression denotes −/− true
T17031 2067-2098 Protein_modification denotes Post-translational modification
T17032 2384-2398 Positive_regulation denotes in response to
T17033 2417-2431 Phosphorylation denotes phosphorylated
T17034 2543-2557 Phosphorylation denotes phosphorylated
T17035 233-244 Localization denotes translocate
T17036 2581-2585 Positive_regulation denotes upon
T17037 2607-2622 Phosphorylation denotes Phosphorylation
T17038 2653-2667 Positive_regulation denotes in response to
T17039 2856-2865 Regulation denotes modulated
T17040 2870-2885 Phosphorylation denotes phosphorylation
T17041 2949-2965 Negative_regulation denotes kinase deficient
T17042 3066-3080 Regulation denotes point mutation
T17043 3143-3150 Negative_regulation denotes lacking
T17044 3272-3303 Protein_modification denotes post-translational modification
T17045 3435-3444 Positive_regulation denotes activated
T17046 295-308 Localization denotes translocation
T17047 3462-3477 Phosphorylation denotes phosphorylation
T17048 3519-3528 Regulation denotes dependent
T17049 3794-3804 Gene_expression denotes Expression
T17050 3875-3885 Negative_regulation denotes inhibition
T17051 4070-4078 Positive_regulation denotes inducing
T17052 4086-4101 Phosphorylation denotes phosphorylation
T17053 4199-4212 Negative_regulation denotes downregulated
T17054 4219-4228 Positive_regulation denotes induction
T17055 4553-4568 Phosphorylation denotes phosphorylation
T17056 4586-4594 Negative_regulation denotes prevents
T17057 859-869 Positive_regulation denotes stimulated
T17058 4611-4613 Positive_regulation denotes by
T17059 4599-4610 Protein_catabolism denotes degradation
T17060 4624-4632 Positive_regulation denotes mediated
T17061 4633-4644 Protein_catabolism denotes proteolysis
T17062 4714-4724 Gene_expression denotes expression
T17063 5265-5274 Gene_expression denotes expressed
T17064 5265-5274 Gene_expression denotes expressed
T17065 5364-5370 Gene_expression denotes devoid true
T17066 5440-5450 Gene_expression denotes expression
T17067 5707-5722 Phosphorylation denotes phosphorylation
T17068 1029-1045 Negative_regulation denotes kinase deficient
T17069 5755-5762 Negative_regulation denotes absence
T17070 5771-5782 Protein_catabolism denotes degradation
T17071 6030-6061 Protein_modification denotes post-translational modification
T17072 6079-6085 Regulation denotes affect true
T17073 6090-6101 Binding denotes interaction
T17074 6193-6201 Regulation denotes involved true
T17075 6210-6221 Protein_catabolism denotes degradation
T17076 6193-6201 Regulation denotes involved true
T17077 6257-6264 Positive_regulation denotes induced
T17078 6243-6256 Localization denotes translocation
T17079 1167-1176 Negative_regulation denotes reduction
T17080 6290-6297 Positive_regulation denotes induced
T17081 6298-6313 Phosphorylation denotes phosphorylation
T17082 6354-6361 Negative_regulation denotes reduced
T17083 6400-6416 Negative_regulation denotes kinase deficient
T17084 6354-6361 Negative_regulation denotes reduced
T17085 6768-6778 Gene_expression denotes expression
T17086 6812-6820 Positive_regulation denotes elevated
T17087 6832-6841 Positive_regulation denotes increased
T17088 6859-6869 Gene_expression denotes expression
T17089 6870-6877 Positive_regulation denotes through
T17090 1186-1193 Positive_regulation denotes induced
T17091 6898-6909 Protein_catabolism denotes degradation
T17092 7132-7139 Negative_regulation denotes reduced
T17093 7132-7139 Negative_regulation denotes reduced
T17094 7306-7322 Negative_regulation denotes kinase-deficient
T17095 7464-7471 Positive_regulation denotes mediate
T17096 7491-7501 Positive_regulation denotes activation
T17097 7518-7533 Phosphorylation denotes phosphorylating
T17098 1194-1209 Phosphorylation denotes phosphorylation
T17099 1308-1317 Negative_regulation denotes inhibited
T17100 212-215 Protein denotes p50
T17101 1590-1593 Protein denotes p65
T17102 4579-4585 Entity denotes Ser276
T17103 1649-1652 Protein denotes p65
T17104 5736-5739 Protein denotes p65
T17105 5766-5770 Protein denotes IκBα
T17106 6071-6074 Protein denotes p65
T17107 6205-6209 Protein denotes IκBα
T17108 6231-6234 Protein denotes p65
T17109 6323-6326 Protein denotes p65
T17110 6417-6421 Protein denotes PKCα
T17111 6429-6434 Protein denotes siRNA
T17112 6443-6447 Protein denotes PKCα
T17113 1724-1727 Protein denotes p65
T17114 6782-6786 Protein denotes IKKα
T17115 6842-6845 Protein denotes p52
T17116 6853-6857 Protein denotes relB
T17117 6917-6921 Protein denotes p100
T17118 7140-7149 Protein denotes caspase-3
T17119 7154-7156 Protein denotes -9
T17120 7323-7327 Protein denotes PKCα
T17121 7511-7514 Protein denotes p65
T17122 2108-2111 Protein denotes p65
T17123 6235-6242 Entity denotes nuclear
T17124 6330-6336 Entity denotes Ser276
T17125 2219-2222 Protein denotes p65
T17126 7534-7540 Entity denotes Ser276
T17127 2410-2413 Protein denotes p65
T17128 2561-2565 Protein denotes MSK1
T17129 2586-2590 Protein denotes TNFα
T17130 2632-2635 Protein denotes p65
T17131 216-219 Protein denotes p65
T17132 2714-2718 Protein denotes IKKα
T17133 2720-2724 Protein denotes IKKβ
T17134 2729-2733 Protein denotes RSK1
T17135 2899-2902 Protein denotes p65
T17136 2966-2970 Protein denotes PKCα
T17137 3100-3103 Protein denotes p65
T17138 3168-3171 Protein denotes p65
T17139 3189-3192 Protein denotes p65
T17140 3313-3316 Protein denotes p65
T17141 289-294 Protein denotes their
T17142 252-259 Entity denotes nucleus
T17143 1226-1232 Entity denotes Ser276
T17144 870-874 Protein denotes PKCα
T17145 1347-1353 Entity denotes Ser276
T17146 1365-1371 Entity denotes Ser536
T17147 1613-1619 Entity denotes Ser276
T17148 2456-2462 Entity denotes Ser276
T17149 1046-1050 Protein denotes PKCα
T17150 2529-2535 Entity denotes Ser276
T17151 2639-2645 Entity denotes Ser536
T17152 2914-2920 Entity denotes Ser536
T17153 1054-1064 Protein denotes PKCα siRNA
T17154 3084-3090 Entity denotes Ser536
T17155 3451-3454 Protein denotes p65
T17156 3514-3518 Protein denotes PKCα
T17157 3537-3541 Protein denotes PKCα
T17158 3671-3675 Protein denotes PKCα
T17159 3808-3812 Protein denotes PKCα
T17160 3870-3874 Protein denotes PKCα
T17161 1219-1222 Protein denotes p65
T17162 3977-3999 Protein denotes dominant negative PKCα
T17163 4012-4016 Protein denotes PKCα
T17164 4111-4114 Protein denotes p65
T17165 4256-4262 Protein denotes BCL-xL
T17166 4572-4575 Protein denotes p65
T17167 4614-4623 Protein denotes ubiquitin
T17168 4707-4713 Protein denotes BCL-xL
T17169 4791-4795 Protein denotes PKCα
T17170 5127-5131 Protein denotes PKCα
T17171 5184-5189 Protein denotes PKCβI
T17172 1269-1291 Protein denotes dominant negative PKCα
T17173 5190-5193 Protein denotes βII
T17174 5242-5247 Protein denotes PKCβI
T17175 5248-5251 Protein denotes βII
T17176 5385-5391 Protein denotes PKCβII
T17177 5408-5412 Protein denotes TNFα
T17178 5454-5460 Protein denotes PKCβII
T17179 5510-5514 Protein denotes TNFα
T17180 5547-5553 Protein denotes PKCβII
T17181 1324-1327 Protein denotes p65
T17182 3455-3461 Entity denotes Ser276
T17183 4079-4085 Entity denotes Ser276
T17184 703-708 Protein denotes M-CSF
T17185 853-858 Protein denotes M-CSF
T17186 1073-1078 Protein denotes M-CSF
T17187 1180-1185 Protein denotes M-CSF
T17188 1430-1435 Protein denotes M-CSF
T17189 1524-1529 Protein denotes M-CSF
T17190 2845-2850 Protein denotes M-CSF
T17191 3429-3434 Protein denotes M-CSF
T17192 4033-4038 Protein denotes M-CSF
T17193 4871-4876 Protein denotes M-CSF
T17194 5041-5046 Protein denotes M-CSF
T17195 6268-6273 Protein denotes M-CSF
T17196 6284-6289 Protein denotes M-CSF
T17197 6594-6599 Protein denotes M-CSF
T17198 6963-6968 Protein denotes M-CSF
T17199 7126-7131 Protein denotes M-CSF
T17200 7336-7341 Protein denotes M-CSF
T17201 7454-7459 Protein denotes M-CSF
T26885 2017-2027 Positive_regulation denotes activating
T26886 2038-2053 Phosphorylation denotes phosphorylation
T26887 2034-2037 Protein denotes p65
T26888 2057-2063 Entity denotes Ser276
T26889 1963-1968 Protein denotes M-CSF
R13014 T17025 T17099 themeOf phosphorylation,inhibited
R13015 T17027 T17026 themeOf phosphorylation,inhibited
R13016 T17029 T17028 themeOf phosphorylation,activating
R13017 T17033 T17032 themeOf phosphorylated,in response to
R13018 T17034 T17036 themeOf phosphorylated,upon
R13019 T17037 T17038 themeOf Phosphorylation,in response to
R13020 T17040 T17039 themeOf phosphorylation,modulated
R13021 T17045 T17048 themeOf activated,dependent
R13022 T17096 T17095 themeOf activation,mediate
R13023 T17097 T17096 causeOf phosphorylating,activation
R13024 T17047 T17045 themeOf phosphorylation,activated
R13025 T17098 T17090 themeOf phosphorylation,induced
R13026 T17052 T17051 themeOf phosphorylation,inducing
R13027 T17100 T17024 themeOf p50,translocate
R13028 T17102 T17055 themeOf Ser276,phosphorylation
R13029 T17102 T17166 partOf Ser276,p65
R13030 T17103 T17030 themeOf p65,−/−
R13031 T17104 T17067 themeOf p65,phosphorylation
R13032 T17105 T17070 themeOf IκBα,degradation
R13033 T17106 T17071 themeOf p65,post-translational modification
R13034 T17106 T17073 themeOf p65,interaction
R13035 T17107 T17075 themeOf IκBα,degradation
R13036 T17108 T17078 themeOf p65,translocation
R13037 T17054 T17053 themeOf induction,downregulated
R13038 T17110 T17083 themeOf PKCα,kinase deficient
R13039 T17111 T17084 causeOf siRNA,reduced
R13040 T17055 T17056 causeOf phosphorylation,prevents
R13041 T17114 T17085 themeOf IKKα,expression
R13042 T17115 T17088 themeOf p52,expression
R13043 T17058 T17056 themeOf by,prevents
R13044 T17116 T17115 equivalentTo relB,p52
R13045 T17117 T17091 themeOf p100,degradation
R13046 T17118 T17092 themeOf caspase-3,reduced
R13047 T17119 T17093 themeOf -9,reduced
R13048 T17120 T17094 themeOf PKCα,kinase-deficient
R13049 T17059 T17058 themeOf degradation,by
R13050 T17121 T17096 themeOf p65,activation
R13051 T17122 T17031 themeOf p65,Post-translational modification
R13052 T17123 T17078 locationOf nuclear,translocation
R13053 T17060 T17058 causeOf mediated,by
R13054 T17124 T17081 themeOf Ser276,phosphorylation
R13055 T17124 T17109 partOf Ser276,p65
R13056 T17126 T17097 themeOf Ser276,phosphorylating
R13057 T17126 T17121 partOf Ser276,p65
R13058 T17061 T17060 themeOf proteolysis,mediated
R13059 T17128 T17034 causeOf MSK1,phosphorylated
R13060 T17129 T17036 causeOf TNFα,upon
R13061 T17070 T17069 themeOf degradation,absence
R13062 T17131 T17035 themeOf p65,translocate
R13063 T17071 T17072 causeOf post-translational modification,affect
R13064 T17073 T17072 themeOf interaction,affect
R13065 T17136 T17041 themeOf PKCα,kinase deficient
R13066 T17075 T17074 themeOf degradation,involved
R13067 T17138 T17043 themeOf p65,lacking
R13068 T17140 T17044 themeOf p65,post-translational modification
R13069 T17077 T17076 themeOf induced,involved
R13070 T17141 T17046 themeOf their,translocation
R13071 T17142 T17024 locationOf nucleus,translocate
R13072 T17142 T17035 locationOf nucleus,translocate
R13073 T17143 T17098 themeOf Ser276,phosphorylation
R13074 T17143 T17161 partOf Ser276,p65
R13075 T17144 T17057 themeOf PKCα,stimulated
R13076 T17077 T17080 themeOf induced,induced
R13077 T17145 T17025 themeOf Ser276,phosphorylation
R13078 T17145 T17181 partOf Ser276,p65
R13079 T17146 T17027 themeOf Ser536,phosphorylation
R13080 T17146 T17181 partOf Ser536,p65
R13081 T17147 T17029 themeOf Ser276,phosphorylation
R13082 T17147 T17101 partOf Ser276,p65
R13083 T17148 T17033 themeOf Ser276,phosphorylated
R13084 T17148 T17127 partOf Ser276,p65
R13085 T17149 T17068 themeOf PKCα,kinase deficient
R13086 T17150 T17034 themeOf Ser276,phosphorylated
R13087 T17150 T17127 partOf Ser276,p65
R13088 T17151 T17037 themeOf Ser536,Phosphorylation
R13089 T17151 T17130 partOf Ser536,p65
R13090 T17078 T17077 themeOf translocation,induced
R13091 T17152 T17040 themeOf Ser536,phosphorylation
R13092 T17152 T17135 partOf Ser536,p65
R13093 T17154 T17042 themeOf Ser536,point mutation
R13094 T17154 T17137 partOf Ser536,p65
R13095 T17080 T17082 themeOf induced,reduced
R13096 T17156 T17048 causeOf PKCα,dependent
R13097 T17159 T17049 themeOf PKCα,Expression
R13098 T17080 T17084 themeOf induced,reduced
R13099 T17160 T17050 themeOf PKCα,inhibition
R13100 T17083 T17082 causeOf kinase deficient,reduced
R13101 T17163 T17051 causeOf PKCα,inducing
R13102 T17085 T17087 causeOf expression,increased
R13103 T17165 T17054 themeOf BCL-xL,induction
R13104 T17166 T17059 themeOf p65,degradation
R13105 T17166 T17061 themeOf p65,proteolysis
R13106 T17167 T17060 causeOf ubiquitin,mediated
R13107 T17168 T17062 themeOf BCL-xL,expression
R13108 T17085 T17086 themeOf expression,elevated
R13109 T17087 T17089 themeOf increased,through
R13110 T17172 T17099 causeOf dominant negative PKCα,inhibited
R13111 T17172 T17026 causeOf dominant negative PKCα,inhibited
R13112 T17174 T17063 themeOf PKCβI,expressed
R13113 T17088 T17087 themeOf expression,increased
R13114 T17175 T17064 themeOf βII,expressed
R13115 T17176 T17065 themeOf PKCβII,devoid
R13116 T17090 T17079 themeOf induced,reduction
R13117 T17178 T17066 themeOf PKCβII,expression
R13118 T17091 T17089 causeOf degradation,through
R13119 T17182 T17047 themeOf Ser276,phosphorylation
R13120 T17182 T17155 partOf Ser276,p65
R13122 T17183 T17052 themeOf Ser276,phosphorylation
R13123 T17183 T17164 partOf Ser276,p65
R13124 T17185 T17057 causeOf M-CSF,stimulated
R13125 T17187 T17090 causeOf M-CSF,induced
R13126 T17190 T17039 causeOf M-CSF,modulated
R13127 T17191 T17045 causeOf M-CSF,activated
R13128 T17195 T17077 causeOf M-CSF,induced
R13129 T17196 T17080 causeOf M-CSF,induced
R13130 T17199 T17092 causeOf M-CSF,reduced
R13131 T17199 T17093 causeOf M-CSF,reduced
R20508 T26886 T26885 themeOf phosphorylation,activating
R20509 T26888 T26886 themeOf Ser276,phosphorylation
R20510 T26888 T26887 partOf Ser276,p65

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T18343 206-211 Protein denotes NF-κB
T18344 212-215 Protein denotes p50
T18345 216-219 Protein denotes p65
T18346 252-259 Entity denotes nucleus
T18347 295-308 Localization denotes translocation
T18348 295-308 Localization denotes translocation
T18349 295-308 Localization denotes translocation
T18350 233-244 Localization denotes translocate
T18351 233-244 Localization denotes translocate
T18352 233-244 Localization denotes translocate
T18353 394-399 Protein denotes NF-κB
T18354 421-436 Phosphorylation denotes phosphorylation
T18355 457-468 Positive_regulation denotes contributes
T18356 527-532 Protein denotes NF-κB
T18357 703-708 Protein denotes M-CSF
T18358 718-723 Protein denotes NF-κB
T18359 752-762 Protein denotes human MDMs
T18360 568-575 Entity denotes nucleus
T18361 853-858 Protein denotes M-CSF
T18362 870-881 Protein denotes PKCα kinase
T18363 894-899 Protein denotes NF-κB
T18364 859-869 Positive_regulation denotes stimulated
T18365 1013-1016 Protein denotes PKC
T18366 1046-1064 Protein denotes PKCα or PKCα siRNA
T18367 1105-1110 Protein denotes NF-κB
T18368 1017-1027 Negative_regulation denotes inhibitors
T18369 1017-1027 Negative_regulation denotes inhibitors
T18370 978-988 Negative_regulation denotes inhibition
T18371 978-988 Negative_regulation denotes inhibition
T18372 1213-1222 Protein denotes NF-κB p65
T18373 1194-1209 Phosphorylation denotes phosphorylation
T18374 1167-1176 Negative_regulation denotes reduction
T18375 1287-1302 Protein denotes PKCα constructs
T18376 1318-1323 Protein denotes NF-κB
T18377 1324-1327 Protein denotes p65
T18378 1385-1398 Protein denotes reduced NF-κB
T18379 1430-1435 Protein denotes M-CSF
T18380 1328-1343 Phosphorylation denotes phosphorylation
T18381 1328-1343 Phosphorylation denotes phosphorylation
T18382 1415-1425 Positive_regulation denotes activation
T18383 1308-1317 Negative_regulation denotes inhibited
T18384 1308-1317 Negative_regulation denotes inhibited
T18385 1524-1529 Protein denotes M-CSF
T18386 1584-1589 Protein denotes NF-κB
T18387 1590-1593 Protein denotes p65
T18388 1624-1627 Protein denotes PKC
T18389 1594-1609 Phosphorylation denotes phosphorylation
T18390 1594-1609 Phosphorylation denotes phosphorylation
T18391 1573-1583 Positive_regulation denotes activating
T18392 1573-1583 Positive_regulation denotes activating
T18393 1560-1569 Regulation denotes regulated
T18394 1560-1569 Regulation denotes regulated
T18395 1643-1648 Protein denotes NF-κB
T18396 1718-1727 Protein denotes NF-κB p65
T18397 1759-1762 Protein denotes PKC
T18398 1777-1782 Protein denotes NF-κB
T18399 1763-1773 Positive_regulation denotes modulation
T18400 1763-1773 Positive_regulation denotes modulation
T18401 2102-2107 Protein denotes NF-κB
T18402 2108-2111 Protein denotes p65
T18403 2213-2218 Protein denotes NF-κB
T18404 2219-2222 Protein denotes p65
T18405 2299-2304 Protein denotes NF-κB
T18406 2399-2402 Protein denotes LPS
T18407 2404-2413 Protein denotes NF-κB p65
T18408 2499-2507 Protein denotes PKA [16]
T18409 2417-2431 Phosphorylation denotes phosphorylated
T18410 2417-2431 Phosphorylation denotes phosphorylated
T18411 2387-2395 Positive_regulation denotes response
T18412 2387-2395 Positive_regulation denotes response
T18413 2524-2527 Protein denotes PKA
T18414 2529-2535 Protein denotes Ser276
T18415 2561-2565 Protein denotes MSK1
T18416 2573-2590 Protein denotes nucleus upon TNFα
T18417 2543-2557 Phosphorylation denotes phosphorylated
T18418 2626-2635 Protein denotes NF-κB p65
T18419 2714-2718 Protein denotes IKKα
T18420 2720-2724 Protein denotes IKKβ
T18421 2729-2733 Protein denotes RSK1
T18422 2607-2622 Phosphorylation denotes Phosphorylation
T18423 2814-2819 Protein denotes NF-κB
T18424 2845-2850 Protein denotes M-CSF
T18425 2893-2910 Protein denotes NF-κB p65 subunit
T18426 2931-2934 Protein denotes PKC
T18427 2966-2970 Protein denotes PKCα
T18428 2788-2803 Phosphorylation denotes phosphorylating
T18429 2870-2885 Phosphorylation denotes phosphorylation
T18430 2914-2920 Entity denotes Ser536
T18431 2935-2945 Negative_regulation denotes inhibitors
T18432 2956-2965 Negative_regulation denotes deficient
T18433 2856-2865 Positive_regulation denotes modulated
T18434 3094-3103 Protein denotes NF-κB p65
T18435 3119-3124 Protein denotes NF-κB
T18436 3162-3171 Protein denotes NF-κB p65
T18437 3183-3188 Protein denotes NF-κB
T18438 3189-3192 Protein denotes p65
T18439 3214-3226 Protein denotes reduce NF-κB
T18440 3112-3118 Negative_regulation denotes reduce
T18441 3307-3316 Protein denotes NF-κB p65
T18442 3429-3434 Protein denotes M-CSF
T18443 3445-3450 Protein denotes NF-κB
T18444 3451-3454 Protein denotes p65
T18445 3455-3461 Protein denotes Ser276
T18446 3514-3518 Protein denotes PKCα
T18447 3462-3477 Phosphorylation denotes phosphorylation
T18448 3462-3477 Phosphorylation denotes phosphorylation
T18449 3462-3477 Phosphorylation denotes phosphorylation
T18450 3498-3508 Positive_regulation denotes activation
T18451 3498-3508 Positive_regulation denotes activation
T18452 3498-3508 Positive_regulation denotes activation
T18453 3435-3444 Positive_regulation denotes activated
T18454 3435-3444 Positive_regulation denotes activated
T18455 3435-3444 Positive_regulation denotes activated
T18456 3435-3444 Positive_regulation denotes activated
T18457 3435-3444 Positive_regulation denotes activated
T18458 3435-3444 Positive_regulation denotes activated
T18459 3537-3541 Protein denotes PKCα
T18460 3574-3603 Protein denotes PKC family of protein kinases
T18461 3671-3675 Protein denotes PKCα
T18462 3808-3812 Protein denotes PKCα
T18463 3870-3874 Protein denotes PKCα
T18464 3794-3804 Gene_expression denotes Expression
T18465 3875-3885 Negative_regulation denotes inhibition
T18466 3958-3961 Protein denotes PKC
T18467 3977-4010 Protein denotes dominant negative PKCα constructs
T18468 4012-4016 Protein denotes PKCα
T18469 4033-4038 Protein denotes M-CSF
T18470 4105-4114 Protein denotes NF-κB p65
T18471 3962-3972 Negative_regulation denotes inhibitors
T18472 3962-3972 Negative_regulation denotes inhibitors
T18473 4079-4085 Entity denotes Ser276
T18474 4086-4101 Phosphorylation denotes phosphorylation
T18475 4070-4078 Positive_regulation denotes inducing
T18476 4184-4187 Protein denotes PKC
T18477 4213-4218 Protein denotes NF-κB
T18478 4219-4228 Positive_regulation denotes induction
T18479 4188-4198 Negative_regulation denotes inhibition
T18480 4199-4212 Negative_regulation denotes downregulated
T18481 4219-4228 Positive_regulation denotes induction
T18482 4309-4314 Protein denotes NF-κB
T18483 4393-4413 Protein denotes BCL-2 family members
T18484 4334-4344 Gene_expression denotes expression
T18485 4572-4575 Protein denotes p65
T18486 4614-4623 Protein denotes ubiquitin
T18487 4553-4568 Phosphorylation denotes phosphorylation
T18488 4633-4644 Protein_catabolism denotes proteolysis
T18489 4791-4805 Protein denotes PKCα-regulated
T18490 4806-4811 Protein denotes NF-κB
T18491 4871-4876 Protein denotes M-CSF
T18492 5009-5013 Protein denotes PKCs
T18493 5041-5046 Protein denotes M-CSF
T18494 5055-5060 Protein denotes NF-κB
T18495 5127-5131 Protein denotes PKCα
T18496 5165-5177 Protein denotes PKC isoforms
T18497 5184-5189 Protein denotes PKCβI
T18498 5190-5193 Protein denotes βII
T18499 5132-5142 Positive_regulation denotes activation
T18500 5132-5142 Positive_regulation denotes activation
T18501 5202-5211 Positive_regulation denotes necessary
T18502 5202-5211 Positive_regulation denotes necessary
T18503 5242-5260 Protein denotes PKCβI/βII isoforms
T18504 5265-5274 Gene_expression denotes expressed
T18505 5385-5391 Protein denotes PKCβII
T18506 5408-5412 Protein denotes TNFα
T18507 5454-5460 Protein denotes PKCβII
T18508 5510-5514 Protein denotes TNFα
T18509 5547-5553 Protein denotes PKCβII
T18510 5437-5450 Gene_expression denotes Re-expression
T18511 5656-5661 Protein denotes NF-κB
T18512 5730-5747 Protein denotes NF-κB p65 subunit
T18513 5766-5770 Protein denotes IκBα
T18514 5707-5722 Phosphorylation denotes phosphorylation
T18515 5771-5782 Protein_catabolism denotes degradation
T18516 5755-5762 Positive_regulation denotes absence
T18517 5694-5703 Regulation denotes regulated
T18518 5825-5830 Protein denotes NF-κB
T18519 5806-5821 Phosphorylation denotes phosphorylation
T18520 5831-5840 Regulation denotes regulates
T18521 5845-5856 Binding denotes interaction
T18522 5975-5980 Protein denotes NF-κB
T18523 6065-6074 Protein denotes NF-κB p65
T18524 5985-5989 Binding denotes bind
T18525 6090-6101 Binding denotes interaction
T18526 6079-6085 Regulation denotes affect
T18527 6185-6188 Protein denotes PKC
T18528 6205-6209 Protein denotes IκBα
T18529 6225-6230 Protein denotes NF-κB
T18530 6231-6234 Protein denotes p65
T18531 6268-6273 Protein denotes M-CSF
T18532 6284-6289 Protein denotes M-CSF
T18533 6317-6326 Protein denotes NF-κB p65
T18534 6382-6385 Protein denotes PKC
T18535 6417-6421 Protein denotes PKCα
T18536 6443-6447 Protein denotes PKCα
T18537 6210-6221 Protein_catabolism denotes degradation
T18538 6235-6242 Entity denotes nuclear
T18539 6243-6256 Localization denotes translocation
T18540 6243-6256 Localization denotes translocation
T18541 6257-6264 Positive_regulation denotes induced
T18542 6330-6336 Entity denotes Ser276
T18543 6386-6395 Negative_regulation denotes inhibitor
T18544 6407-6416 Negative_regulation denotes deficient
T18545 6193-6201 Positive_regulation denotes involved
T18546 6193-6201 Positive_regulation denotes involved
T18547 6298-6313 Phosphorylation denotes phosphorylation
T18548 6290-6297 Positive_regulation denotes induced
T18549 6533-6538 Protein denotes NF-κB
T18550 6594-6599 Protein denotes M-CSF
T18551 6604-6607 Protein denotes PKC
T18552 6523-6532 Positive_regulation denotes activated
T18553 6608-6618 Positive_regulation denotes activation
T18554 6582-6590 Positive_regulation denotes response
T18555 6782-6786 Protein denotes IKKα
T18556 6842-6845 Protein denotes p52
T18557 6846-6851 Protein denotes NF-κB
T18558 6853-6857 Protein denotes relB
T18559 6917-6921 Protein denotes p100
T18560 6922-6935 Protein denotes NF-κB protein
T18561 6768-6778 Gene_expression denotes expression
T18562 6812-6820 Positive_regulation denotes elevated
T18563 6859-6869 Gene_expression denotes expression
T18564 6859-6869 Gene_expression denotes expression
T18565 6859-6869 Gene_expression denotes expression
T18566 6898-6909 Protein_catabolism denotes degradation
T18567 6898-6909 Protein_catabolism denotes degradation
T18568 6832-6841 Positive_regulation denotes increased
T18569 6832-6841 Positive_regulation denotes increased
T18570 6832-6841 Positive_regulation denotes increased
T18571 6963-6968 Protein denotes M-CSF
T18572 7042-7047 Protein denotes NF-κB
T18573 7126-7131 Protein denotes M-CSF
T18574 7140-7149 Protein denotes caspase-3
T18575 7132-7139 Negative_regulation denotes reduced
T18576 7269-7272 Protein denotes PKC
T18577 7323-7327 Protein denotes PKCα
T18578 7336-7341 Protein denotes M-CSF
T18579 7273-7283 Negative_regulation denotes inhibitors
T18580 7288-7302 Gene_expression denotes overexpression
T18581 7288-7302 Positive_regulation denotes overexpression
T18582 7273-7283 Negative_regulation denotes inhibitors
T18583 7273-7283 Negative_regulation denotes inhibitors
T18584 7401-7405 Protein denotes PKCs
T18585 7422-7427 Protein denotes NF-κB
T18586 7454-7459 Protein denotes M-CSF
T18587 7505-7514 Protein denotes NF-κB p65
T18588 7428-7438 Positive_regulation denotes activation
T18589 7491-7501 Positive_regulation denotes activation
T18590 7464-7471 Positive_regulation denotes mediate
T26921 1999-2002 Protein denotes PKC
T26922 2028-2033 Protein denotes NF-κB
T26923 2034-2037 Protein denotes p65
T26924 2003-2013 Regulation denotes regulation
T26925 2038-2053 Phosphorylation denotes phosphorylation
T26926 2038-2053 Phosphorylation denotes phosphorylation
T26927 2017-2027 Positive_regulation denotes activating
T26928 2017-2027 Positive_regulation denotes activating
R13723 T18343 T18347 themeOf NF-κB,translocation
R13731 T18343 T18350 themeOf NF-κB,translocate
R13733 T18344 T18348 themeOf p50,translocation
R13738 T18344 T18351 themeOf p50,translocate
R13740 T18345 T18349 themeOf p65,translocation
R13741 T18345 T18352 themeOf p65,translocate
R13742 T18346 T18350 locationOf nucleus,translocate
R13743 T18346 T18351 locationOf nucleus,translocate
R13744 T18346 T18352 locationOf nucleus,translocate
R13746 T18353 T18354 themeOf NF-κB,phosphorylation
R13750 T18354 T18355 themeOf phosphorylation,contributes
R13752 T18361 T18364 causeOf M-CSF,stimulated
R13762 T18362 T18364 themeOf PKCα kinase,stimulated
R13769 T18365 T18368 themeOf PKC,inhibitors
R13774 T18366 T18369 themeOf PKCα or PKCα siRNA,inhibitors
R13777 T18366 T18370 themeOf PKCα or PKCα siRNA,inhibition
R13779 T18366 T18371 themeOf PKCα or PKCα siRNA,inhibition
R13780 T18368 T18370 causeOf inhibitors,inhibition
R13784 T18369 T18371 causeOf inhibitors,inhibition
R13786 T18372 T18373 themeOf NF-κB p65,phosphorylation
R13791 T18373 T18374 themeOf phosphorylation,reduction
R13793 T18375 T18383 causeOf PKCα constructs,inhibited
R13797 T18375 T18384 causeOf PKCα constructs,inhibited
R13799 T18376 T18380 themeOf NF-κB,phosphorylation
R13801 T18377 T18381 themeOf p65,phosphorylation
R13802 T18378 T18382 themeOf reduced NF-κB,activation
R13808 T18380 T18383 themeOf phosphorylation,inhibited
R13809 T18381 T18384 themeOf phosphorylation,inhibited
R13810 T18386 T18389 themeOf NF-κB,phosphorylation
R13811 T18387 T18390 themeOf p65,phosphorylation
R13812 T18388 T18391 causeOf PKC,activating
R13813 T18388 T18392 causeOf PKC,activating
R13814 T18389 T18391 themeOf phosphorylation,activating
R13815 T18423 T18428 themeOf NF-κB,phosphorylating
R13816 T18390 T18392 themeOf phosphorylation,activating
R13817 T18391 T18393 themeOf activating,regulated
R13818 T18392 T18394 themeOf activating,regulated
R13819 T18424 T18433 causeOf M-CSF,modulated
R13820 T18397 T18399 themeOf PKC,modulation
R13821 T18425 T18429 themeOf NF-κB p65 subunit,phosphorylation
R13822 T18398 T18400 themeOf NF-κB,modulation
R13823 T18425 T18430 partOf NF-κB p65 subunit,Ser536
R13824 T18426 T18431 themeOf PKC,inhibitors
R13825 T18427 T18432 themeOf PKCα,deficient
R13826 T18407 T18409 themeOf NF-κB p65,phosphorylated
R13827 T18408 T18410 themeOf PKA [16],phosphorylated
R13828 T18429 T18433 themeOf phosphorylation,modulated
R13829 T18409 T18411 themeOf phosphorylated,response
R13830 T18410 T18412 themeOf phosphorylated,response
R13831 T18430 T18433 Site Ser536,modulated
R13832 T18414 T18417 themeOf Ser276,phosphorylated
R13833 T18435 T18440 themeOf NF-κB,reduce
R13834 T18418 T18422 themeOf NF-κB p65,Phosphorylation
R13835 T18442 T18453 causeOf M-CSF,activated
R13836 T18442 T18454 causeOf M-CSF,activated
R13837 T18507 T18510 themeOf PKCβII,Re-expression
R13838 T18442 T18455 causeOf M-CSF,activated
R13839 T18442 T18456 causeOf M-CSF,activated
R13840 T18442 T18457 causeOf M-CSF,activated
R13841 T18442 T18458 causeOf M-CSF,activated
R13842 T18443 T18447 themeOf NF-κB,phosphorylation
R13843 T18512 T18514 themeOf NF-κB p65 subunit,phosphorylation
R13844 T18513 T18515 themeOf IκBα,degradation
R13845 T18514 T18517 causeOf phosphorylation,regulated
R13846 T18515 T18516 themeOf degradation,absence
R13847 T18444 T18448 themeOf p65,phosphorylation
R13848 T18516 T18517 themeOf absence,regulated
R13849 T18445 T18449 themeOf Ser276,phosphorylation
R13850 T18518 T18519 themeOf NF-κB,phosphorylation
R13851 T18518 T18521 themeOf NF-κB,interaction
R13852 T18519 T18520 themeOf phosphorylation,regulates
R13853 T18522 T18524 themeOf NF-κB,bind
R13854 T18523 T18525 themeOf NF-κB p65,interaction
R13855 T18447 T18450 themeOf phosphorylation,activation
R13856 T18525 T18526 themeOf interaction,affect
R13857 T18527 T18545 causeOf PKC,involved
R13858 T18527 T18546 causeOf PKC,involved
R13859 T18528 T18537 themeOf IκBα,degradation
R13860 T18447 T18453 themeOf phosphorylation,activated
R13861 T18529 T18539 themeOf NF-κB,translocation
R13862 T18448 T18451 themeOf phosphorylation,activation
R13863 T18530 T18540 themeOf p65,translocation
R13864 T18531 T18541 causeOf M-CSF,induced
R13865 T18532 T18548 causeOf M-CSF,induced
R13866 T18533 T18547 themeOf NF-κB p65,phosphorylation
R13867 T18533 T18542 partOf NF-κB p65,Ser276
R13868 T18448 T18454 themeOf phosphorylation,activated
R13869 T18534 T18543 themeOf PKC,inhibitor
R13870 T18535 T18544 themeOf PKCα,deficient
R13871 T18449 T18452 themeOf phosphorylation,activation
R13872 T18537 T18541 themeOf degradation,induced
R13873 T18449 T18455 themeOf phosphorylation,activated
R13874 T18538 T18539 locationOf nuclear,translocation
R13875 T18538 T18540 locationOf nuclear,translocation
R13876 T18539 T18545 themeOf translocation,involved
R13877 T18450 T18456 themeOf activation,activated
R13878 T18540 T18546 themeOf translocation,involved
R13879 T18542 T18547 Site Ser276,phosphorylation
R13880 T18451 T18457 themeOf activation,activated
R13881 T18452 T18458 themeOf activation,activated
R13882 T18547 T18548 themeOf phosphorylation,induced
R13883 T18462 T18464 themeOf PKCα,Expression
R13884 T18549 T18552 themeOf NF-κB,activated
R13885 T18551 T18553 themeOf PKC,activation
R13886 T18553 T18554 themeOf activation,response
R13887 T18555 T18561 themeOf IKKα,expression
R13888 T18556 T18563 themeOf p52,expression
R13889 T18557 T18564 themeOf NF-κB,expression
R13890 T18463 T18465 themeOf PKCα,inhibition
R13891 T18466 T18471 themeOf PKC,inhibitors
R13892 T18558 T18565 themeOf relB,expression
R13893 T18559 T18566 themeOf p100,degradation
R13894 T18560 T18567 themeOf NF-κB protein,degradation
R13895 T18561 T18562 themeOf expression,elevated
R13896 T18467 T18472 themeOf dominant negative PKCα constructs,inhibitors
R13897 T18563 T18568 themeOf expression,increased
R13898 T18564 T18569 themeOf expression,increased
R13899 T18468 T18475 causeOf PKCα,inducing
R13900 T18565 T18570 themeOf expression,increased
R13901 T18470 T18474 themeOf NF-κB p65,phosphorylation
R13902 T18573 T18575 causeOf M-CSF,reduced
R13903 T18470 T18473 partOf NF-κB p65,Ser276
R13904 T18574 T18575 themeOf caspase-3,reduced
R13905 T18473 T18474 Site Ser276,phosphorylation
R13906 T18576 T18579 themeOf PKC,inhibitors
R13907 T18577 T18580 themeOf PKCα,overexpression
R13908 T18474 T18475 themeOf phosphorylation,inducing
R13909 T18580 T18581 themeOf overexpression,overexpression
R13910 T18580 T18582 themeOf overexpression,inhibitors
R13911 T18581 T18583 themeOf overexpression,inhibitors
R13912 T18476 T18478 themeOf PKC,induction
R13913 T18584 T18590 causeOf PKCs,mediate
R13914 T18585 T18588 themeOf NF-κB,activation
R13915 T18477 T18478 causeOf NF-κB,induction
R13916 T18587 T18589 themeOf NF-κB p65,activation
R13917 T18589 T18590 themeOf activation,mediate
R13918 T18477 T18481 causeOf NF-κB,induction
R13919 T18478 T18479 themeOf induction,inhibition
R13920 T18478 T18480 themeOf induction,downregulated
R13921 T18480 T18481 themeOf downregulated,induction
R13922 T18483 T18484 themeOf BCL-2 family members,expression
R13923 T18485 T18487 themeOf p65,phosphorylation
R13924 T18486 T18488 themeOf ubiquitin,proteolysis
R13925 T18495 T18499 themeOf PKCα,activation
R13926 T18496 T18500 themeOf PKC isoforms,activation
R13927 T18497 T18501 themeOf PKCβI,necessary
R13928 T18498 T18502 themeOf βII,necessary
R13929 T18503 T18504 themeOf PKCβI/βII isoforms,expressed
R20527 T26921 T26924 themeOf PKC,regulation
R20528 T26922 T26925 themeOf NF-κB,phosphorylation
R20529 T26923 T26926 themeOf p65,phosphorylation
R20530 T26925 T26927 themeOf phosphorylation,activating
R20531 T26926 T26928 themeOf phosphorylation,activating

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T18164 212-215 Protein denotes p50
T18165 216-219 Protein denotes p65
T18166 233-244 Localization denotes translocate
T18167 233-244 Localization denotes translocate
T18168 252-259 Entity denotes nucleus
T18169 289-294 Protein denotes their
T18170 295-308 Localization denotes translocation
T18171 703-708 Protein denotes M-CSF
T18172 853-858 Protein denotes M-CSF
T18173 859-869 Positive_regulation denotes stimulated
T18174 870-874 Protein denotes PKCα
T18175 1029-1045 Negative_regulation denotes kinase deficient
T18176 1046-1050 Protein denotes PKCα
T18177 1054-1064 Protein denotes PKCα siRNA
T18178 1073-1078 Protein denotes M-CSF
T18179 1167-1176 Negative_regulation denotes reduction
T18180 1180-1185 Protein denotes M-CSF
T18181 1186-1193 Positive_regulation denotes induced
T18182 1194-1209 Phosphorylation denotes phosphorylation
T18183 1219-1222 Protein denotes p65
T18184 1226-1232 Entity denotes Ser276
T18185 1269-1291 Protein denotes dominant negative PKCα
T18186 1308-1317 Negative_regulation denotes inhibited true
T18187 1308-1317 Negative_regulation denotes inhibited
T18188 1324-1327 Protein denotes p65
T18189 1328-1343 Phosphorylation denotes phosphorylation
T18190 1328-1343 Phosphorylation denotes phosphorylation
T18191 1347-1353 Entity denotes Ser276
T18192 1365-1371 Entity denotes Ser536
T18193 1430-1435 Protein denotes M-CSF
T18194 1524-1529 Protein denotes M-CSF
T18195 1573-1583 Positive_regulation denotes activating
T18196 1590-1593 Protein denotes p65
T18197 1594-1609 Phosphorylation denotes phosphorylation
T18198 1613-1619 Entity denotes Ser276
T18199 1649-1652 Protein denotes p65
T18200 1652-1655 Gene_expression denotes −/− true
T18201 1724-1727 Protein denotes p65
T18202 2067-2098 Protein_modification denotes Post-translational modification
T18203 2108-2111 Protein denotes p65
T18204 2219-2222 Protein denotes p65
T18205 2384-2398 Positive_regulation denotes in response to
T18206 2410-2413 Protein denotes p65
T18207 2417-2431 Phosphorylation denotes phosphorylated
T18208 2456-2462 Entity denotes Ser276
T18209 2529-2535 Entity denotes Ser276
T18210 2543-2557 Phosphorylation denotes phosphorylated
T18211 2561-2565 Protein denotes MSK1
T18212 2581-2585 Positive_regulation denotes upon
T18213 2586-2590 Protein denotes TNFα
T18214 2607-2622 Phosphorylation denotes Phosphorylation
T18215 2632-2635 Protein denotes p65
T18216 2639-2645 Entity denotes Ser536
T18217 2653-2667 Positive_regulation denotes in response to
T18218 2714-2718 Protein denotes IKKα
T18219 2720-2724 Protein denotes IKKβ
T18220 2729-2733 Protein denotes RSK1
T18221 2845-2850 Protein denotes M-CSF
T18222 2856-2865 Regulation denotes modulated
T18223 2870-2885 Phosphorylation denotes phosphorylation
T18224 2899-2902 Protein denotes p65
T18225 2914-2920 Entity denotes Ser536
T18226 2949-2965 Negative_regulation denotes kinase deficient
T18227 2966-2970 Protein denotes PKCα
T18228 3066-3080 Regulation denotes point mutation
T18229 3084-3090 Entity denotes Ser536
T18230 3100-3103 Protein denotes p65
T18231 3143-3150 Negative_regulation denotes lacking
T18232 3168-3171 Protein denotes p65
T18233 3189-3192 Protein denotes p65
T18234 3272-3303 Protein_modification denotes post-translational modification
T18235 3313-3316 Protein denotes p65
T18236 3429-3434 Protein denotes M-CSF
T18237 3435-3444 Positive_regulation denotes activated
T18238 3451-3454 Protein denotes p65
T18239 3455-3461 Entity denotes Ser276
T18240 3462-3477 Phosphorylation denotes phosphorylation
T18241 3514-3518 Protein denotes PKCα
T18242 3519-3528 Regulation denotes dependent
T18243 3537-3541 Protein denotes PKCα
T18244 3671-3675 Protein denotes PKCα
T18245 3794-3804 Gene_expression denotes Expression
T18246 3808-3812 Protein denotes PKCα
T18247 3870-3874 Protein denotes PKCα
T18248 3875-3885 Negative_regulation denotes inhibition
T18249 3977-3999 Protein denotes dominant negative PKCα
T18250 4012-4016 Protein denotes PKCα
T18251 4033-4038 Protein denotes M-CSF
T18252 4070-4078 Positive_regulation denotes inducing
T18253 4079-4085 Entity denotes Ser276
T18254 4086-4101 Phosphorylation denotes phosphorylation
T18255 4111-4114 Protein denotes p65
T18256 4199-4212 Negative_regulation denotes downregulated
T18257 4219-4228 Positive_regulation denotes induction
T18258 4256-4262 Protein denotes BCL-xL
T18259 4553-4568 Phosphorylation denotes phosphorylation
T18260 4572-4575 Protein denotes p65
T18261 4579-4585 Entity denotes Ser276
T18262 4586-4594 Negative_regulation denotes prevents
T18263 4599-4610 Protein_catabolism denotes degradation
T18264 4611-4613 Positive_regulation denotes by
T18265 4614-4623 Protein denotes ubiquitin
T18266 4624-4632 Positive_regulation denotes mediated
T18267 4633-4644 Protein_catabolism denotes proteolysis
T18268 4707-4713 Protein denotes BCL-xL
T18269 4714-4724 Gene_expression denotes expression
T18270 4791-4795 Protein denotes PKCα
T18271 4871-4876 Protein denotes M-CSF
T18272 5041-5046 Protein denotes M-CSF
T18273 5127-5131 Protein denotes PKCα
T18274 5184-5189 Protein denotes PKCβI
T18275 5190-5193 Protein denotes βII
T18276 5242-5247 Protein denotes PKCβI
T18277 5248-5251 Protein denotes βII
T18278 5265-5274 Gene_expression denotes expressed
T18279 5265-5274 Gene_expression denotes expressed
T18280 5364-5370 Gene_expression denotes devoid true
T18281 5385-5391 Protein denotes PKCβII
T18282 5408-5412 Protein denotes TNFα
T18283 5440-5450 Gene_expression denotes expression
T18284 5454-5460 Protein denotes PKCβII
T18285 5510-5514 Protein denotes TNFα
T18286 5547-5553 Protein denotes PKCβII
T18287 5707-5722 Phosphorylation denotes phosphorylation
T18288 5736-5739 Protein denotes p65
T18289 5755-5762 Negative_regulation denotes absence
T18290 5766-5770 Protein denotes IκBα
T18291 5771-5782 Protein_catabolism denotes degradation
T18292 6030-6061 Protein_modification denotes post-translational modification
T18293 6071-6074 Protein denotes p65
T18294 6079-6085 Regulation denotes affect true
T18295 6090-6101 Binding denotes interaction
T18296 6193-6201 Regulation denotes involved true
T18297 6193-6201 Regulation denotes involved true
T18298 6205-6209 Protein denotes IκBα
T18299 6210-6221 Protein_catabolism denotes degradation
T18300 6231-6234 Protein denotes p65
T18301 6235-6242 Entity denotes nuclear
T18302 6243-6256 Localization denotes translocation
T18303 6257-6264 Positive_regulation denotes induced
T18304 6268-6273 Protein denotes M-CSF
T18305 6284-6289 Protein denotes M-CSF
T18306 6290-6297 Positive_regulation denotes induced
T18307 6298-6313 Phosphorylation denotes phosphorylation
T18308 6323-6326 Protein denotes p65
T18309 6330-6336 Entity denotes Ser276
T18310 6354-6361 Negative_regulation denotes reduced
T18311 6354-6361 Negative_regulation denotes reduced
T18312 6400-6416 Negative_regulation denotes kinase deficient
T18313 6417-6421 Protein denotes PKCα
T18314 6429-6434 Protein denotes siRNA
T18315 6443-6447 Protein denotes PKCα
T18316 6594-6599 Protein denotes M-CSF
T18317 6768-6778 Gene_expression denotes expression
T18318 6782-6786 Protein denotes IKKα
T18319 6812-6820 Positive_regulation denotes elevated
T18320 6832-6841 Positive_regulation denotes increased
T18321 6842-6845 Protein denotes p52
T18322 6853-6857 Protein denotes relB
T18323 6859-6869 Gene_expression denotes expression
T18324 6870-6877 Positive_regulation denotes through
T18325 6898-6909 Protein_catabolism denotes degradation
T18326 6917-6921 Protein denotes p100
T18327 6963-6968 Protein denotes M-CSF
T18328 7126-7131 Protein denotes M-CSF
T18329 7132-7139 Negative_regulation denotes reduced
T18330 7132-7139 Negative_regulation denotes reduced
T18331 7140-7149 Protein denotes caspase-3
T18332 7154-7156 Protein denotes -9
T18333 7306-7322 Negative_regulation denotes kinase-deficient
T18334 7323-7327 Protein denotes PKCα
T18335 7336-7341 Protein denotes M-CSF
T18336 7454-7459 Protein denotes M-CSF
T18337 7464-7471 Positive_regulation denotes mediate
T18338 7491-7501 Positive_regulation denotes activation
T18339 7511-7514 Protein denotes p65
T18340 7518-7533 Phosphorylation denotes phosphorylating
T18341 7534-7540 Entity denotes Ser276
T26916 1963-1968 Protein denotes M-CSF
T26917 2017-2027 Positive_regulation denotes activating
T26918 2034-2037 Protein denotes p65
T26919 2038-2053 Phosphorylation denotes phosphorylation
T26920 2057-2063 Entity denotes Ser276
R13632 T18164 T18166 themeOf p50,translocate
R13633 T18165 T18167 themeOf p65,translocate
R13635 T18168 T18166 locationOf nucleus,translocate
R13636 T18168 T18167 locationOf nucleus,translocate
R13638 T18169 T18170 themeOf their,translocation
R13640 T18172 T18173 causeOf M-CSF,stimulated
R13642 T18174 T18173 themeOf PKCα,stimulated
R13644 T18176 T18175 themeOf PKCα,kinase deficient
R13648 T18180 T18181 causeOf M-CSF,induced
R13649 T18181 T18179 themeOf induced,reduction
R13650 T18182 T18181 themeOf phosphorylation,induced
R13651 T18184 T18182 themeOf Ser276,phosphorylation
R13652 T18184 T18183 partOf Ser276,p65
R13653 T18185 T18187 causeOf dominant negative PKCα,inhibited
R13654 T18185 T18186 causeOf dominant negative PKCα,inhibited
R13656 T18189 T18187 themeOf phosphorylation,inhibited
R13657 T18190 T18186 themeOf phosphorylation,inhibited
R13658 T18191 T18189 themeOf Ser276,phosphorylation
R13659 T18191 T18188 partOf Ser276,p65
R13661 T18192 T18190 themeOf Ser536,phosphorylation
R13662 T18192 T18188 partOf Ser536,p65
R13664 T18197 T18195 themeOf phosphorylation,activating
R13666 T18198 T18197 themeOf Ser276,phosphorylation
R13667 T18198 T18196 partOf Ser276,p65
R13668 T18199 T18200 themeOf p65,−/−
R13671 T18203 T18202 themeOf p65,Post-translational modification
R13674 T18207 T18205 themeOf phosphorylated,in response to
R13675 T18208 T18207 themeOf Ser276,phosphorylated
R13676 T18208 T18206 partOf Ser276,p65
R13677 T18209 T18210 themeOf Ser276,phosphorylated
R13678 T18209 T18206 partOf Ser276,p65
R13680 T18210 T18212 themeOf phosphorylated,upon
R13681 T18211 T18210 causeOf MSK1,phosphorylated
R13683 T18213 T18212 causeOf TNFα,upon
R13684 T18214 T18217 themeOf Phosphorylation,in response to
R13686 T18216 T18214 themeOf Ser536,Phosphorylation
R13687 T18216 T18215 partOf Ser536,p65
R13689 T18221 T18222 causeOf M-CSF,modulated
R13692 T18223 T18222 themeOf phosphorylation,modulated
R13693 T18225 T18223 themeOf Ser536,phosphorylation
R13694 T18225 T18224 partOf Ser536,p65
R13695 T18227 T18226 themeOf PKCα,kinase deficient
R13697 T18229 T18228 themeOf Ser536,point mutation
R13698 T18229 T18230 partOf Ser536,p65
R13700 T18232 T18231 themeOf p65,lacking
R13702 T18235 T18234 themeOf p65,post-translational modification
R13703 T18236 T18237 causeOf M-CSF,activated
R13704 T18237 T18242 themeOf activated,dependent
R13705 T18239 T18240 themeOf Ser276,phosphorylation
R13706 T18239 T18238 partOf Ser276,p65
R13707 T18240 T18237 themeOf phosphorylation,activated
R13709 T18241 T18242 causeOf PKCα,dependent
R13712 T18246 T18245 themeOf PKCα,Expression
R13713 T18247 T18248 themeOf PKCα,inhibition
R13715 T18250 T18252 causeOf PKCα,inducing
R13717 T18253 T18254 themeOf Ser276,phosphorylation
R13718 T18253 T18255 partOf Ser276,p65
R13719 T18254 T18252 themeOf phosphorylation,inducing
R13724 T18257 T18256 themeOf induction,downregulated
R13725 T18258 T18257 themeOf BCL-xL,induction
R13726 T18259 T18262 causeOf phosphorylation,prevents
R13727 T18260 T18263 themeOf p65,degradation
R13728 T18260 T18267 themeOf p65,proteolysis
R13729 T18261 T18259 themeOf Ser276,phosphorylation
R13730 T18261 T18260 partOf Ser276,p65
R13732 T18263 T18264 themeOf degradation,by
R13734 T18264 T18262 themeOf by,prevents
R13735 T18265 T18266 causeOf ubiquitin,mediated
R13736 T18266 T18264 causeOf mediated,by
R13737 T18267 T18266 themeOf proteolysis,mediated
R13739 T18268 T18269 themeOf BCL-xL,expression
R13745 T18276 T18278 themeOf PKCβI,expressed
R13747 T18277 T18279 themeOf βII,expressed
R13748 T18281 T18280 themeOf PKCβII,devoid
R13749 T18284 T18283 themeOf PKCβII,expression
R13751 T18288 T18287 themeOf p65,phosphorylation
R13753 T18290 T18291 themeOf IκBα,degradation
R13754 T18291 T18289 themeOf degradation,absence
R13755 T18292 T18294 causeOf post-translational modification,affect
R13756 T18293 T18292 themeOf p65,post-translational modification
R13757 T18293 T18295 themeOf p65,interaction
R13758 T18295 T18294 themeOf interaction,affect
R13759 T18298 T18299 themeOf IκBα,degradation
R13760 T18299 T18296 themeOf degradation,involved
R13761 T18300 T18302 themeOf p65,translocation
R13763 T18301 T18302 locationOf nuclear,translocation
R13764 T18302 T18303 themeOf translocation,induced
R13765 T18303 T18297 themeOf induced,involved
R13766 T18303 T18306 themeOf induced,induced
R13767 T18304 T18303 causeOf M-CSF,induced
R13768 T18305 T18306 causeOf M-CSF,induced
R13770 T18306 T18310 themeOf induced,reduced
R13771 T18306 T18311 themeOf induced,reduced
R13772 T18309 T18307 themeOf Ser276,phosphorylation
R13773 T18309 T18308 partOf Ser276,p65
R13775 T18312 T18310 causeOf kinase deficient,reduced
R13776 T18313 T18312 themeOf PKCα,kinase deficient
R13778 T18314 T18311 causeOf siRNA,reduced
R13781 T18317 T18320 causeOf expression,increased
R13782 T18317 T18319 themeOf expression,elevated
R13783 T18318 T18317 themeOf IKKα,expression
R13785 T18320 T18324 themeOf increased,through
R13787 T18321 T18323 themeOf p52,expression
R13788 T18322 T18321 equivalentTo relB,p52
R13789 T18323 T18320 themeOf expression,increased
R13790 T18325 T18324 causeOf degradation,through
R13792 T18326 T18325 themeOf p100,degradation
R13794 T18328 T18329 causeOf M-CSF,reduced
R13795 T18328 T18330 causeOf M-CSF,reduced
R13796 T18331 T18329 themeOf caspase-3,reduced
R13798 T18332 T18330 themeOf -9,reduced
R13800 T18334 T18333 themeOf PKCα,kinase-deficient
R13803 T18338 T18337 themeOf activation,mediate
R13804 T18339 T18338 themeOf p65,activation
R13805 T18340 T18338 causeOf phosphorylating,activation
R13806 T18341 T18340 themeOf Ser276,phosphorylating
R13807 T18341 T18339 partOf Ser276,p65
R20524 T26919 T26917 themeOf phosphorylation,activating
R20525 T26920 T26919 themeOf Ser276,phosphorylation
R20526 T26920 T26918 partOf Ser276,p65

GO-CC

Id Subject Object Predicate Lexical cue
T17282 69-82 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T17283 252-259 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T17284 568-575 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T17285 2573-2580 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T17286 269-278 http://purl.obolibrary.org/obo/GO_0005737 denotes cytoplasm
T17287 961-966 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17288 3137-3142 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17289 3245-3250 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17290 4156-4161 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17291 4680-4685 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17292 5308-5313 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17293 5471-5476 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17294 7350-7354 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T17295 7576-7580 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T17296 2499-2502 http://purl.obolibrary.org/obo/GO_0005952 denotes PKA
T17297 2524-2527 http://purl.obolibrary.org/obo/GO_0005952 denotes PKA
T17298 6495-6512 http://purl.obolibrary.org/obo/GO_0043234 denotes protein complexes

GO-MF

Id Subject Object Predicate Lexical cue
T17247 870-874 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T17248 1046-1050 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T17249 1054-1058 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T17250 1287-1291 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T17251 2966-2970 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T17252 3514-3518 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T17253 3537-3541 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T17254 3671-3675 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T17255 3808-3812 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T17256 3870-3874 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T17257 3995-3999 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T17258 4012-4016 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T17259 4791-4795 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T17260 5127-5131 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T17261 6417-6421 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T17262 6443-6447 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T17263 1013-1016 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T17264 1624-1627 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T17265 1759-1762 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T17266 2931-2934 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T17267 3574-3577 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T17268 3958-3961 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T17269 4184-4187 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T17270 5165-5168 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T17271 6185-6188 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T17272 6382-6385 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T17273 6604-6607 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T17274 7269-7272 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T17275 2283-2294 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T17276 2287-2294 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T17277 2287-2304 http://purl.obolibrary.org/obo/GO_0051059 denotes binding and NF-κB
T17278 2499-2502 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA
T17279 2524-2527 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA
T17280 4614-4623 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T17281 6549-6578 http://purl.obolibrary.org/obo/GO_0003713 denotes transcriptional co-activators
T26891 1999-2002 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC

GO-BP

Id Subject Object Predicate Lexical cue
T18592 5892-5907 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T18593 3664-3669 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T18594 3824-3833 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T18595 3908-3917 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T18596 4431-4440 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T18597 4480-4489 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T18598 5227-5236 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T18599 5421-5430 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T18600 5523-5532 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T18601 5612-5621 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T18602 6549-6564 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T18603 7189-7198 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T18604 3824-3833 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T18605 3908-3917 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T18606 4431-4440 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T18607 4480-4489 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T18608 5227-5236 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T18609 5421-5430 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T18610 5523-5532 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T18611 5612-5621 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T18612 7189-7198 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T18613 7558-7571 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T18614 4599-4610 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T18615 5771-5782 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T18616 6210-6221 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T18617 6898-6909 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T18618 4633-4644 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T18619 5061-5086 http://purl.obolibrary.org/obo/GO_0042116 denotes activation and macrophage
T18620 5216-5236 http://purl.obolibrary.org/obo/GO_0071888 denotes macrophage apoptosis
T18621 5601-5621 http://purl.obolibrary.org/obo/GO_0071888 denotes macrophage apoptosis
T18622 6549-6578 http://purl.obolibrary.org/obo/GO_0003713 denotes transcriptional co-activators
T18623 6582-6599 http://purl.obolibrary.org/obo/GO_1903969 denotes response to M-CSF
T18624 83-92 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18625 7442-7459 http://purl.obolibrary.org/obo/GO_1903969 denotes response to M-CSF
T18626 6582-6599 http://purl.obolibrary.org/obo/GO_0036005 denotes response to M-CSF
T18627 7442-7459 http://purl.obolibrary.org/obo/GO_0036005 denotes response to M-CSF
T18628 6582-6599 http://purl.obolibrary.org/obo/GO_1903970 denotes response to M-CSF
T18629 7442-7459 http://purl.obolibrary.org/obo/GO_1903970 denotes response to M-CSF
T18630 6604-6618 http://purl.obolibrary.org/obo/GO_1990051 denotes PKC activation
T18631 6714-6740 http://purl.obolibrary.org/obo/GO_0030225 denotes macrophage differentiation
T18632 3729-3736 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T18633 94-109 http://purl.obolibrary.org/obo/GO_0006950 denotes stress response
T18634 156-168 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T18635 339-363 http://purl.obolibrary.org/obo/GO_0016441 denotes gene transcription. Post
T18636 2067-2098 http://purl.obolibrary.org/obo/GO_0043687 denotes Post-translational modification
T18637 476-491 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T18638 3272-3303 http://purl.obolibrary.org/obo/GO_0043687 denotes post-translational modification
T18639 6030-6061 http://purl.obolibrary.org/obo/GO_0043687 denotes post-translational modification
T18640 2067-2098 http://purl.obolibrary.org/obo/GO_1901873 denotes Post-translational modification
T18641 3272-3303 http://purl.obolibrary.org/obo/GO_1901873 denotes post-translational modification
T18642 6030-6061 http://purl.obolibrary.org/obo/GO_1901873 denotes post-translational modification
T18643 2067-2098 http://purl.obolibrary.org/obo/GO_1901874 denotes Post-translational modification
T18644 3272-3303 http://purl.obolibrary.org/obo/GO_1901874 denotes post-translational modification
T18645 6030-6061 http://purl.obolibrary.org/obo/GO_1901874 denotes post-translational modification
T18646 724-739 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T18647 2067-2098 http://purl.obolibrary.org/obo/GO_1901875 denotes Post-translational modification
T18648 3272-3303 http://purl.obolibrary.org/obo/GO_1901875 denotes post-translational modification
T18649 6030-6061 http://purl.obolibrary.org/obo/GO_1901875 denotes post-translational modification
T18650 7472-7501 http://purl.obolibrary.org/obo/GO_1901875 denotes post-translational activation
T18651 421-436 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18652 1194-1209 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18653 1328-1343 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18654 1594-1609 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18655 2223-2238 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18656 900-915 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T18657 2870-2885 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18658 3002-3017 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18659 3462-3477 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18660 4086-4101 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18661 4553-4568 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18662 5707-5722 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18663 5806-5821 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18664 6298-6313 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18665 1399-1414 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T18666 2305-2320 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T18667 3339-3354 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T18668 1017-1035 http://purl.obolibrary.org/obo/GO_0033673 denotes inhibitors, kinase
T18669 2935-2955 http://purl.obolibrary.org/obo/GO_0033673 denotes inhibitors or kinase
T18670 6386-6406 http://purl.obolibrary.org/obo/GO_0033673 denotes inhibitor and kinase
T18671 1121-1136 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T18672 3482-3497 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T18673 2162-2177 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T18674 4329-4344 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T18675 6136-6154 http://purl.obolibrary.org/obo/GO_0010467 denotes expression of gene
T18676 1393-1425 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB transcriptional activation
T18677 1573-1589 http://purl.obolibrary.org/obo/GO_0051092 denotes activating NF-κB
T18678 6523-6538 http://purl.obolibrary.org/obo/GO_0051092 denotes activated NF-κB
T18679 7422-7438 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T18680 1839-1849 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T18681 5662-5677 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T18682 2387-2402 http://purl.obolibrary.org/obo/GO_0032496 denotes response to LPS
T18683 2499-2502 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA
T18684 2524-2527 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA
T18685 3429-3444 http://purl.obolibrary.org/obo/GO_1901258 denotes M-CSF activated
T18686 3429-3444 http://purl.obolibrary.org/obo/GO_1903971 denotes M-CSF activated
T18687 3626-3637 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T18688 3631-3637 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T18689 3639-3663 http://purl.obolibrary.org/obo/GO_0030154 denotes differentiation and cell
T26929 1999-2013 http://purl.obolibrary.org/obo/GO_1900019 denotes PKC regulation
T26930 2003-2013 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T26931 2017-2033 http://purl.obolibrary.org/obo/GO_0051092 denotes activating NF-κB
T26932 2038-2053 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T16909 4595-4598 Anaphor denotes its
T16910 4572-4575 Antecedent denotes p65
T16911 6086-6089 Anaphor denotes its
T16912 6071-6074 Antecedent denotes p65
R12998 T16909 T16910 boundBy its,p65
R12999 T16911 T16912 boundBy its,p65

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T15746 58-68 VB denotes regulating
T15747 69-82 JJ denotes intracellular
T15748 83-92 NN denotes signaling
T15749 92-93 -COMMA- denotes ,
T15750 94-100 NN denotes stress
T15751 101-109 NN denotes response
T15752 109-110 -COMMA- denotes ,
T15753 111-124 NN denotes proliferation
T15754 124-125 -COMMA- denotes ,
T15755 126-134 NN denotes survival
T15756 134-135 -COMMA- denotes ,
T15757 136-151 NN denotes differentiation
T15758 152-155 CC denotes and
T15759 156-168 NN denotes inflammation
T15760 169-170 -LRB- denotes [
T15761 170-171 CD denotes 8
T15762 171-172 -RRB- denotes ]
T15763 174-176 TO denotes To
T15764 177-185 VB denotes regulate
T15765 186-190 NN denotes gene
T15766 191-204 NN denotes transcription
T15767 204-205 -COMMA- denotes ,
T15768 206-211 NN denotes NF-κB
T15769 212-219 NN denotes p50/p65
T15770 220-232 NN denotes heterodimers
T15772 245-247 TO denotes to
T15773 248-251 DT denotes the
T15774 252-259 NN denotes nucleus
T15775 260-264 IN denotes from
T15776 265-268 DT denotes the
T15777 269-278 NN denotes cytoplasm
T15778 278-279 -COMMA- denotes ,
T15779 280-287 RB denotes however
T15780 287-288 -COMMA- denotes ,
T15781 289-294 PRP-DOLLAR- denotes their
T15782 295-308 NN denotes translocation
T15783 309-311 VB denotes is
T15784 312-315 RB denotes not
T15785 316-326 JJ denotes sufficient
T15786 327-329 TO denotes to
T15787 330-338 VB denotes activate
T15788 339-343 NN denotes gene
T15789 344-357 NN denotes transcription
T15790 359-377 JJ denotes Post-translational
T15791 378-390 NN denotes modification
T15792 391-393 IN denotes of
T15793 394-399 NN denotes NF-κB
T15794 400-412 NN denotes heterodimers
T15795 413-417 JJ denotes such
T15796 418-420 IN denotes as
T15797 421-436 NN denotes phosphorylation
T15798 437-439 CC denotes or
T15799 440-451 NN denotes acetylation
T15800 452-456 RB denotes also
T15801 457-468 VB denotes contributes
T15802 469-471 TO denotes to
T15803 472-475 PRP-DOLLAR- denotes its
T15804 476-491 JJ denotes transcriptional
T15805 492-500 NN denotes activity
T15806 501-502 -LRB- denotes [
T15807 502-504 CD denotes 41
T15808 504-505 -RRB- denotes ]
T15809 505-506 -COMMA- denotes ,
T15810 507-508 -LRB- denotes [
T15811 508-510 CD denotes 42
T15812 510-511 -RRB- denotes ]
T15813 511-512 -COMMA- denotes ,
T15814 513-514 -LRB- denotes [
T15815 514-516 CD denotes 43
T15816 516-517 -RRB- denotes ]
T15817 519-526 IN denotes Because
T15818 527-532 NN denotes NF-κB
T15819 533-547 RB denotes constitutively
T15820 548-560 VB denotes translocates
T15821 561-563 TO denotes to
T15822 564-567 DT denotes the
T15823 568-575 NN denotes nucleus
T15824 576-578 IN denotes in
T15825 579-588 JJ denotes monocytic
T15826 589-596 NN denotes lineage
T15827 597-598 -LRB- denotes [
T15828 598-600 CD denotes 13
T15829 600-601 -RRB- denotes ]
T15830 602-605 CC denotes and
T15831 606-615 VB denotes activates
T15832 616-620 NN denotes gene
T15833 621-634 NN denotes transcription
T15834 635-638 CC denotes and
T15835 639-647 NN denotes survival
T15836 648-650 IN denotes in
T15837 651-657 JJ denotes murine
T15838 658-669 NN denotes macrophages
T15839 670-671 -LRB- denotes [
T15840 671-673 CD denotes 11
T15841 673-674 -RRB- denotes ]
T15842 674-675 -COMMA- denotes ,
T15843 676-678 PRP denotes we
T15844 679-685 VB denotes sought
T15845 686-688 TO denotes to
T15846 689-698 VB denotes determine
T15847 699-702 WRB denotes how
T15848 703-708 NN denotes M-CSF
T15849 709-717 VB denotes affected
T15850 718-723 NN denotes NF-κB
T15851 724-739 JJ denotes transcriptional
T15852 740-748 NN denotes activity
T15853 749-751 IN denotes in
T15854 752-757 JJ denotes human
T15855 758-762 NN denotes MDMs
T15856 763-766 CC denotes and
T15857 767-774 IN denotes whether
T15858 775-779 DT denotes this
T15859 780-790 NN denotes activation
T15860 791-800 VB denotes regulated
T15861 801-806 PRP-DOLLAR- denotes their
T15862 807-815 NN denotes survival
T15863 817-820 DT denotes The
T15864 821-828 JJ denotes present
T15865 829-834 NN denotes study
T15866 835-847 VB denotes demonstrated
T15867 848-852 IN denotes that
T15868 853-858 NN denotes M-CSF
T15869 859-869 VB denotes stimulated
T15870 870-874 NN denotes PKCα
T15871 875-881 NN denotes kinase
T15872 882-890 RB denotes upstream
T15873 891-893 IN denotes of
T15874 894-899 NN denotes NF-κB
T15875 900-915 JJ denotes transcriptional
T15876 916-924 NN denotes activity
T15877 925-927 IN denotes in
T15878 928-935 JJ denotes primary
T15879 936-941 JJ denotes human
T15880 942-946 NN denotes MDMs
T15881 947-950 CC denotes and
T15882 951-954 NN denotes RAW
T15883 955-960 CD denotes 264.7
T15884 961-966 NN denotes cells
T15885 968-970 PRP denotes We
T15886 971-977 VB denotes showed
T15887 978-988 NN denotes inhibition
T15888 989-991 IN denotes of
T15889 992-1004 JJ denotes conventional
T15890 1005-1009 NN denotes PKCs
T15891 1010-1012 IN denotes by
T15892 1013-1016 NN denotes PKC
T15893 1017-1027 NN denotes inhibitors
T15894 1027-1028 -COMMA- denotes ,
T15895 1029-1035 NN denotes kinase
T15896 1036-1045 JJ denotes deficient
T15897 1046-1050 NN denotes PKCα
T15898 1051-1053 CC denotes or
T15899 1054-1058 NN denotes PKCα
T15900 1059-1064 NN denotes siRNA
T15901 1065-1072 VB denotes blocked
T15902 1073-1086 JJ denotes M-CSF-induced
T15903 1087-1091 NN denotes cell
T15904 1092-1100 NN denotes survival
T15905 1101-1104 CC denotes and
T15906 1105-1120 JJ denotes NF-κB-regulated
T15907 1121-1125 NN denotes gene
T15908 1126-1136 NN denotes expression
T15909 1138-1142 DT denotes This
T15910 1143-1148 NN denotes block
T15911 1149-1159 VB denotes correlated
T15912 1160-1164 IN denotes with
T15913 1165-1166 DT denotes a
T15914 1167-1176 NN denotes reduction
T15915 1177-1179 IN denotes in
T15916 1180-1193 JJ denotes M-CSF-induced
T15917 1194-1209 NN denotes phosphorylation
T15918 1210-1212 IN denotes of
T15919 1213-1218 NN denotes NF-κB
T15920 1219-1222 NN denotes p65
T15921 1223-1225 IN denotes at
T15922 1226-1232 NN denotes Ser276
T15923 1234-1244 JJ denotes Consistent
T15924 1245-1249 IN denotes with
T15925 1250-1255 DT denotes these
T15926 1256-1264 NN denotes findings
T15927 1265-1268 DT denotes the
T15928 1269-1277 JJ denotes dominant
T15929 1278-1286 JJ denotes negative
T15930 1287-1291 NN denotes PKCα
T15931 1292-1302 NN denotes constructs
T15932 1303-1307 RB denotes also
T15933 1308-1317 VB denotes inhibited
T15934 1318-1323 NN denotes NF-κB
T15935 1324-1327 NN denotes p65
T15936 1328-1343 NN denotes phosphorylation
T15937 1344-1346 IN denotes at
T15938 1347-1353 NN denotes Ser276
T15939 1354-1357 CC denotes but
T15940 1358-1361 RB denotes not
T15941 1362-1364 IN denotes at
T15942 1365-1371 NN denotes Ser536
T15943 1372-1381 VB denotes resulting
T15944 1382-1384 IN denotes in
T15945 1385-1392 VB denotes reduced
T15946 1393-1398 NN denotes NF-κB
T15947 1399-1414 JJ denotes transcriptional
T15948 1415-1425 NN denotes activation
T15949 1426-1429 CC denotes and
T15950 1430-1443 JJ denotes M-CSF-induced
T15951 1444-1447 NN denotes MDM
T15952 1448-1456 NN denotes survival
T15953 1458-1459 DT denotes A
T15954 1460-1470 VB denotes simplified
T15955 1471-1479 VB denotes proposed
T15956 1480-1487 NN denotes cartoon
T15957 1488-1493 NN denotes model
T15958 1494-1496 IN denotes in
T15959 1497-1503 NN denotes Figure
T15960 1504-1505 CD denotes 9
T15961 1506-1518 VB denotes demonstrates
T15962 1519-1523 IN denotes that
T15963 1524-1529 NN denotes M-CSF
T15964 1530-1537 VB denotes induced
T15965 1538-1547 NN denotes monocytes
T15966 1548-1556 NN denotes survival
T15967 1557-1559 VB denotes is
T15968 1560-1569 VB denotes regulated
T15969 1570-1572 IN denotes by
T15970 1573-1583 VB denotes activating
T15971 1584-1589 NN denotes NF-κB
T15972 1590-1593 NN denotes p65
T15973 1594-1609 NN denotes phosphorylation
T15974 1610-1612 IN denotes at
T15975 1613-1619 NN denotes Ser276
T15976 1620-1623 IN denotes via
T15977 1624-1627 NN denotes PKC
T15978 1629-1636 RB denotes Finally
T15979 1636-1637 -COMMA- denotes ,
T15980 1638-1640 IN denotes in
T15981 1641-1642 DT denotes a
T15982 1643-1648 NN denotes NF-κB
T15983 1649-1655 NN denotes p65−/−
T15984 1656-1666 NN denotes fibroblast
T15985 1667-1671 NN denotes cell
T15986 1672-1676 NN denotes line
T15987 1676-1677 -COMMA- denotes ,
T15988 1678-1680 PRP denotes we
T15989 1681-1690 VB denotes confirmed
T15990 1691-1695 IN denotes that
T15991 1696-1699 DT denotes the
T15992 1700-1706 NN denotes Ser276
T15993 1707-1714 NN denotes residue
T15994 1715-1717 IN denotes of
T15995 1718-1723 NN denotes NF-κB
T15996 1724-1727 NN denotes p65
T15997 1728-1730 VB denotes is
T15998 1731-1740 JJ denotes important
T15999 1741-1744 CC denotes and
T16000 1745-1754 JJ denotes essential
T16001 1755-1758 IN denotes for
T16002 1759-1762 NN denotes PKC
T16003 1763-1773 NN denotes modulation
T16004 1774-1776 IN denotes of
T16005 1777-1782 NN denotes NF-κB
T16006 1783-1791 NN denotes activity
T16007 1793-1797 RB denotes More
T16008 1798-1808 JJ denotes compelling
T16009 1809-1811 VB denotes is
T16010 1812-1816 IN denotes that
T16011 1817-1819 PRP denotes we
T16012 1820-1828 VB denotes observed
T16013 1829-1830 DT denotes a
T16014 1831-1838 JJ denotes similar
T16015 1839-1849 NN denotes regulation
T16016 1850-1857 IN denotes between
T16017 1858-1861 CD denotes two
T16018 1862-1871 JJ denotes different
T16019 1872-1876 NN denotes cell
T16020 1877-1885 NN denotes lineages
T16021 1886-1888 IN denotes in
T16022 1889-1892 PRP-DOLLAR- denotes our
T16023 1893-1898 NN denotes study
T16024 2067-2085 JJ denotes Post-translational
T16025 2086-2098 NN denotes modification
T16026 2099-2101 IN denotes of
T16027 2102-2107 NN denotes NF-κB
T16028 2108-2111 NN denotes p65
T16029 2112-2121 VB denotes regulates
T16030 2122-2125 PRP-DOLLAR- denotes its
T16031 2126-2136 VB denotes activating
T16032 2137-2139 CC denotes or
T16033 2140-2150 VB denotes repressing
T16034 2151-2158 NN denotes effects
T16035 2159-2161 IN denotes on
T16036 2162-2166 NN denotes gene
T16037 2167-2177 NN denotes expression
T16038 2179-2184 IN denotes Among
T16039 2185-2188 DT denotes the
T16040 2189-2194 CD denotes seven
T16041 2195-2203 VB denotes reported
T16042 2204-2212 JJ denotes putative
T16043 2213-2218 NN denotes NF-κB
T16044 2219-2222 NN denotes p65
T16045 2223-2238 NN denotes phosphorylation
T16046 2239-2244 NN denotes sites
T16047 2244-2245 -COMMA- denotes ,
T16048 2246-2250 CD denotes five
T16049 2251-2259 NN denotes increase
T16050 2260-2267 JJ denotes nuclear
T16051 2268-2281 NN denotes translocation
T16052 2281-2282 -COMMA- denotes ,
T16053 2283-2286 NN denotes DNA
T16054 2287-2294 NN denotes binding
T16055 2295-2298 CC denotes and
T16056 2299-2304 NN denotes NF-κB
T16057 2305-2320 JJ denotes transcriptional
T16058 2321-2329 NN denotes activity
T16059 2330-2331 -LRB- denotes [
T16060 2331-2333 CD denotes 17
T16061 2333-2334 -RRB- denotes ]
T16062 2336-2343 JJ denotes Similar
T16063 2344-2346 TO denotes to
T16064 2347-2350 PRP-DOLLAR- denotes our
T16065 2351-2358 NN denotes finding
T16066 2358-2359 -COMMA- denotes ,
T16067 2360-2365 NNP denotes Zhong
T16068 2366-2368 FW denotes et
T16069 2369-2372 FW denotes al.
T16070 2373-2378 VB denotes found
T16071 2379-2383 IN denotes that
T16072 2384-2386 IN denotes in
T16073 2387-2395 NN denotes response
T16074 2396-2398 TO denotes to
T16075 2399-2402 NN denotes LPS
T16076 2402-2403 -COMMA- denotes ,
T16077 2404-2409 NN denotes NF-κB
T16078 2410-2413 NN denotes p65
T16079 2414-2416 VB denotes is
T16080 2417-2431 VB denotes phosphorylated
T16081 2432-2434 IN denotes at
T16082 2435-2438 DT denotes the
T16083 2439-2445 RB denotes highly
T16084 2446-2455 VB denotes conserved
T16085 2456-2462 NN denotes Ser276
T16086 2463-2470 NN denotes residue
T16087 2471-2473 IN denotes by
T16088 2474-2477 DT denotes the
T16089 2478-2487 JJ denotes catalytic
T16090 2488-2495 NN denotes subunit
T16091 2496-2498 IN denotes of
T16092 2499-2502 NN denotes PKA
T16093 2503-2504 -LRB- denotes [
T16094 2504-2506 CD denotes 16
T16095 2506-2507 -RRB- denotes ]
T16096 2509-2511 IN denotes In
T16097 2512-2520 NN denotes addition
T16098 2521-2523 TO denotes to
T16099 2524-2527 NN denotes PKA
T16100 2527-2528 -COMMA- denotes ,
T16101 2529-2535 NN denotes Ser276
T16102 2536-2539 MD denotes can
T16103 2540-2542 VB denotes be
T16104 2543-2557 VB denotes phosphorylated
T16105 2558-2560 IN denotes by
T16106 2561-2565 NN denotes MSK1
T16107 2566-2568 IN denotes in
T16108 2569-2572 DT denotes the
T16109 2573-2580 NN denotes nucleus
T16110 2581-2585 IN denotes upon
T16111 2586-2590 NN denotes TNFα
T16112 2591-2600 NN denotes treatment
T16113 2601-2602 -LRB- denotes [
T16114 2602-2604 CD denotes 18
T16115 2604-2605 -RRB- denotes ]
T16116 2607-2622 NN denotes Phosphorylation
T16117 2623-2625 IN denotes of
T16118 2626-2631 NN denotes NF-κB
T16119 2632-2635 NN denotes p65
T16120 2636-2638 IN denotes at
T16121 2639-2645 NN denotes Ser536
T16122 2646-2652 VB denotes occurs
T16123 2653-2655 IN denotes in
T16124 2656-2664 NN denotes response
T16125 2665-2667 TO denotes to
T16126 2668-2672 JJ denotes many
T16127 2673-2685 JJ denotes inflammatory
T16128 2686-2693 NN denotes stimuli
T16129 2694-2696 RB denotes as
T16130 2697-2701 RB denotes well
T16131 2702-2704 IN denotes as
T16132 2705-2712 NN denotes kinases
T16133 2712-2713 -COMMA- denotes ,
T16134 2714-2718 NN denotes IKKα
T16135 2718-2719 -COMMA- denotes ,
T16136 2720-2724 NN denotes IKKβ
T16137 2725-2728 CC denotes and
T16138 2729-2733 NN denotes RSK1
T16139 2734-2735 -LRB- denotes [
T16140 2735-2737 CD denotes 17
T16141 2737-2738 -RRB- denotes ]
T16142 2738-2739 -COMMA- denotes ,
T16143 2740-2741 -LRB- denotes [
T16144 2741-2743 CD denotes 18
T16145 2743-2744 -RRB- denotes ]
T16146 2744-2745 -COMMA- denotes ,
T16147 2746-2747 -LRB- denotes [
T16148 2747-2749 CD denotes 19
T16149 2749-2750 -RRB- denotes ]
T16150 2750-2751 -COMMA- denotes ,
T16151 2752-2753 -LRB- denotes [
T16152 2753-2755 CD denotes 20
T16153 2755-2756 -RRB- denotes ]
T16154 2756-2757 -COMMA- denotes ,
T16155 2758-2759 -LRB- denotes [
T16156 2759-2761 CD denotes 21
T16157 2761-2762 -RRB- denotes ]
T16158 2764-2771 RB denotes Notably
T16159 2771-2772 -COMMA- denotes ,
T16160 2773-2775 IN denotes in
T16161 2776-2784 NN denotes addition
T16162 2785-2787 TO denotes to
T16163 2788-2803 VB denotes phosphorylating
T16164 2804-2810 NN denotes Ser276
T16165 2811-2813 IN denotes of
T16166 2814-2819 NN denotes NF-κB
T16167 2819-2820 -COMMA- denotes ,
T16168 2821-2824 PRP-DOLLAR- denotes our
T16169 2825-2830 NN denotes study
T16170 2831-2839 VB denotes revealed
T16171 2840-2844 IN denotes that
T16172 2845-2850 NN denotes M-CSF
T16173 2851-2855 RB denotes also
T16174 2856-2865 VB denotes modulated
T16175 2866-2869 DT denotes the
T16176 2870-2885 NN denotes phosphorylation
T16177 2886-2888 IN denotes of
T16178 2889-2892 DT denotes the
T16179 2893-2898 NN denotes NF-κB
T16180 2899-2902 NN denotes p65
T16181 2903-2910 NN denotes subunit
T16182 2911-2913 IN denotes at
T16183 2914-2920 NN denotes Ser536
T16184 2920-2921 -COMMA- denotes ,
T16185 2922-2929 RB denotes however
T16186 2929-2930 -COMMA- denotes ,
T16187 2931-2934 NN denotes PKC
T16188 2935-2945 NN denotes inhibitors
T16189 2946-2948 CC denotes or
T16190 2949-2955 NN denotes kinase
T16191 2956-2965 JJ denotes deficient
T16192 2966-2970 NN denotes PKCα
T16193 2971-2981 NN denotes constructs
T16194 2982-2985 VB denotes did
T16195 2986-2989 RB denotes not
T16196 2990-2996 VB denotes affect
T16197 2997-3001 DT denotes this
T16198 3002-3017 NN denotes phosphorylation
T16199 3018-3023 NN denotes event
T16200 3025-3033 RB denotes Moreover
T16201 3033-3034 -COMMA- denotes ,
T16202 3035-3041 JJ denotes mutant
T16203 3042-3052 NN denotes constructs
T16204 3053-3063 VB denotes containing
T16205 3064-3065 DT denotes a
T16206 3066-3071 NN denotes point
T16207 3072-3080 NN denotes mutation
T16208 3081-3083 IN denotes at
T16209 3084-3090 NN denotes Ser536
T16210 3091-3093 IN denotes of
T16211 3094-3099 NN denotes NF-κB
T16212 3100-3103 NN denotes p65
T16213 3104-3107 VB denotes did
T16214 3108-3111 RB denotes not
T16215 3112-3118 VB denotes reduce
T16216 3119-3124 NN denotes NF-κB
T16217 3125-3133 NN denotes activity
T16218 3134-3136 IN denotes in
T16219 3137-3142 NN denotes cells
T16220 3143-3150 VB denotes lacking
T16221 3151-3161 JJ denotes endogenous
T16222 3162-3167 NN denotes NF-κB
T16223 3168-3171 NN denotes p65
T16224 3171-3172 -COMMA- denotes ,
T16225 3173-3178 IN denotes while
T16226 3179-3182 DT denotes the
T16227 3183-3188 NN denotes NF-κB
T16228 3189-3192 NN denotes p65
T16229 3193-3199 NN denotes 276S/A
T16230 3200-3209 NN denotes construct
T16231 3210-3213 VB denotes did
T16232 3214-3220 VB denotes reduce
T16233 3221-3226 NN denotes NF-κB
T16234 3227-3235 NN denotes activity
T16235 3236-3238 IN denotes in
T16236 3239-3244 DT denotes these
T16237 3245-3250 NN denotes cells
T16238 3252-3261 RB denotes Therefore
T16239 3261-3262 -COMMA- denotes ,
T16240 3263-3271 JJ denotes specific
T16241 3272-3290 JJ denotes post-translational
T16242 3291-3303 NN denotes modification
T16243 3304-3306 IN denotes of
T16244 3307-3312 NN denotes NF-κB
T16245 3313-3316 NN denotes p65
T16246 3317-3319 VB denotes is
T16247 3320-3326 JJ denotes likely
T16248 3327-3329 TO denotes to
T16249 3330-3338 VB denotes regulate
T16250 3339-3354 JJ denotes transcriptional
T16251 3355-3365 NN denotes activation
T16252 3366-3368 IN denotes in
T16253 3369-3377 NN denotes response
T16254 3378-3380 TO denotes to
T16255 3381-3389 JJ denotes specific
T16256 3390-3397 NN denotes stimuli
T16257 3398-3399 -LRB- denotes [
T16258 3399-3401 CD denotes 15
T16259 3401-3402 -RRB- denotes ]
T16260 3402-3403 -COMMA- denotes ,
T16261 3404-3405 -LRB- denotes [
T16262 3405-3407 CD denotes 43
T16263 3407-3408 -RRB- denotes ]
T16264 3410-3412 PRP denotes It
T16265 3413-3415 VB denotes is
T16266 3416-3423 JJ denotes notable
T16267 3424-3428 IN denotes that
T16268 3429-3434 NN denotes M-CSF
T16269 3435-3444 VB denotes activated
T16270 3445-3450 NN denotes NF-κB
T16271 3451-3454 NN denotes p65
T16272 3455-3461 NN denotes Ser276
T16273 3462-3477 NN denotes phosphorylation
T16274 3478-3481 CC denotes and
T16275 3482-3497 JJ denotes transcriptional
T16276 3498-3508 NN denotes activation
T16277 3509-3511 IN denotes in
T16278 3512-3513 DT denotes a
T16279 3514-3528 JJ denotes PKCα-dependent
T16280 3529-3535 NN denotes manner
T16281 3537-3541 NN denotes PKCα
T16282 3542-3544 VB denotes is
T16283 3545-3546 DT denotes a
T16284 3547-3553 NN denotes member
T16285 3554-3556 IN denotes of
T16286 3557-3560 DT denotes the
T16287 3561-3573 JJ denotes conventional
T16288 3574-3577 NN denotes PKC
T16289 3578-3584 NN denotes family
T16290 3585-3587 IN denotes of
T16291 3588-3595 NN denotes protein
T16292 3596-3603 NN denotes kinases
T16293 3604-3608 WDT denotes that
T16294 3609-3612 VB denotes are
T16295 3613-3621 JJ denotes critical
T16296 3622-3625 IN denotes for
T16297 3626-3630 NN denotes cell
T16298 3631-3637 NN denotes growth
T16299 3637-3638 -COMMA- denotes ,
T16300 3639-3654 NN denotes differentiation
T16301 3655-3658 CC denotes and
T16302 3659-3663 NN denotes cell
T16303 3664-3669 NN denotes death
T16304 3671-3675 NN denotes PKCα
T16305 3676-3685 RB denotes primarily
T16306 3686-3695 VB denotes modulates
T16307 3696-3710 JJ denotes anti-apoptotic
T16308 3711-3714 CC denotes and
T16309 3715-3728 NN denotes proliferation
T16310 3729-3736 NN denotes signals
T16311 3737-3746 VB denotes following
T16312 3747-3755 NN denotes cytokine
T16313 3756-3765 NN denotes treatment
T16314 3766-3768 IN denotes in
T16315 3769-3776 JJ denotes various
T16316 3777-3781 NN denotes cell
T16317 3782-3787 NN denotes types
T16318 3788-3789 -LRB- denotes [
T16319 3789-3791 CD denotes 42
T16320 3791-3792 -RRB- denotes ]
T16321 3794-3804 NN denotes Expression
T16322 3805-3807 IN denotes of
T16323 3808-3812 NN denotes PKCα
T16324 3813-3823 VB denotes attenuates
T16325 3824-3833 NN denotes apoptosis
T16326 3834-3836 IN denotes in
T16327 3837-3841 JJ denotes many
T16328 3842-3851 JJ denotes different
T16329 3852-3856 NN denotes cell
T16330 3857-3862 NN denotes types
T16331 3862-3863 -COMMA- denotes ,
T16332 3864-3869 IN denotes while
T16333 3870-3874 NN denotes PKCα
T16334 3875-3885 NN denotes inhibition
T16335 3886-3895 RB denotes generally
T16336 3896-3907 VB denotes potentiates
T16337 3908-3917 NN denotes apoptosis
T16338 3918-3919 -LRB- denotes [
T16339 3919-3921 CD denotes 42
T16340 3921-3922 -RRB- denotes ]
T16341 3924-3926 IN denotes In
T16342 3927-3930 PRP-DOLLAR- denotes our
T16343 3931-3938 NN denotes studies
T16344 3939-3944 VB denotes using
T16345 3945-3957 JJ denotes conventional
T16346 3958-3961 NN denotes PKC
T16347 3962-3972 NN denotes inhibitors
T16348 3973-3976 CC denotes and
T16349 3977-3985 JJ denotes dominant
T16350 3986-3994 JJ denotes negative
T16351 3995-3999 NN denotes PKCα
T16352 4000-4010 NN denotes constructs
T16353 4010-4011 -COMMA- denotes ,
T16354 4012-4016 NN denotes PKCα
T16355 4017-4020 VB denotes was
T16356 4021-4029 JJ denotes critical
T16357 4030-4032 IN denotes in
T16358 4033-4046 JJ denotes M-CSF-induced
T16359 4047-4057 NN denotes macrophage
T16360 4058-4066 NN denotes survival
T16361 4067-4069 IN denotes by
T16362 4070-4078 VB denotes inducing
T16363 4079-4085 NN denotes Ser276
T16364 4086-4101 NN denotes phosphorylation
T16365 4102-4104 IN denotes of
T16366 4105-4110 NN denotes NF-κB
T16367 4111-4114 NN denotes p65
T16368 4115-4117 IN denotes in
T16369 4118-4122 CC denotes both
T16370 4123-4130 JJ denotes primary
T16371 4131-4136 JJ denotes human
T16372 4137-4141 NN denotes MDMs
T16373 4142-4145 CC denotes and
T16374 4146-4149 NN denotes Raw
T16375 4150-4155 CD denotes 264.7
T16376 4156-4161 NN denotes cells
T16377 4163-4165 PRP denotes We
T16378 4166-4170 RB denotes also
T16379 4171-4183 VB denotes demonstrated
T16380 4184-4187 NN denotes PKC
T16381 4188-4198 NN denotes inhibition
T16382 4199-4212 VB denotes downregulated
T16383 4213-4228 NN denotes NF-κB-induction
T16384 4229-4231 IN denotes of
T16385 4232-4235 DT denotes the
T16386 4236-4250 JJ denotes anti-apoptotic
T16387 4251-4255 NN denotes gene
T16388 4256-4262 NN denotes BCL-xL
T16389 4264-4274 JJ denotes Consistent
T16390 4275-4279 IN denotes with
T16391 4280-4283 PRP-DOLLAR- denotes our
T16392 4284-4291 NN denotes finding
T16393 4291-4292 -COMMA- denotes ,
T16394 4293-4299 NN denotes others
T16395 4300-4308 VB denotes reported
T16396 4309-4314 NN denotes NF-κB
T16397 4315-4324 VB denotes regulated
T16398 4325-4328 DT denotes the
T16399 4329-4333 NN denotes gene
T16400 4334-4344 NN denotes expression
T16401 4345-4347 IN denotes of
T16402 4348-4352 JJ denotes many
T16403 4353-4367 JJ denotes anti-apoptotic
T16404 4368-4376 NN denotes proteins
T16405 4377-4386 VB denotes including
T16406 4387-4392 JJ denotes other
T16407 4393-4398 NN denotes BCL-2
T16408 4399-4405 NN denotes family
T16409 4406-4413 NN denotes members
T16410 4414-4417 CC denotes and
T16411 4418-4427 NN denotes inhibitor
T16412 4428-4430 IN denotes of
T16413 4431-4440 NN denotes apoptosis
T16414 4441-4442 -LRB- denotes (
T16415 4442-4445 NN denotes IAP
T16416 4445-4446 -RRB- denotes )
T16417 4447-4455 NN denotes proteins
T16418 4456-4461 WDT denotes which
T16419 4462-4465 VB denotes are
T16420 4466-4476 NN denotes regulators
T16421 4477-4479 IN denotes of
T16422 4480-4489 NN denotes apoptosis
T16423 4490-4493 CC denotes and
T16424 4494-4502 NN denotes function
T16425 4503-4511 RB denotes upstream
T16426 4512-4514 IN denotes of
T16427 4515-4523 NN denotes caspases
T16428 4524-4525 -LRB- denotes [
T16429 4525-4527 CD denotes 44
T16430 4527-4528 -RRB- denotes ]
T16431 4530-4532 PRP denotes It
T16432 4533-4536 VB denotes has
T16433 4537-4541 VB denotes been
T16434 4542-4547 VB denotes shown
T16435 4548-4552 IN denotes that
T16436 4553-4568 NN denotes phosphorylation
T16437 4569-4571 IN denotes of
T16438 4572-4575 NN denotes p65
T16439 4576-4578 IN denotes at
T16440 4579-4585 NN denotes Ser276
T16441 4586-4594 VB denotes prevents
T16442 4595-4598 PRP-DOLLAR- denotes its
T16443 4599-4610 NN denotes degradation
T16444 4611-4613 IN denotes by
T16445 4614-4632 JJ denotes ubiquitin-mediated
T16446 4633-4644 NN denotes proteolysis
T16447 4645-4648 CC denotes and
T16448 4649-4657 VB denotes promotes
T16449 4658-4662 NN denotes cell
T16450 4663-4671 NN denotes survival
T16451 4672-4674 IN denotes in
T16452 4675-4679 NN denotes HeLa
T16453 4680-4685 NN denotes cells
T16454 4686-4687 -LRB- denotes [
T16455 4687-4689 CD denotes 24
T16456 4689-4690 -RRB- denotes ]
T16457 4692-4694 IN denotes In
T16458 4695-4703 NN denotes addition
T16459 4704-4706 TO denotes to
T16460 4707-4713 NN denotes BCL-xL
T16461 4714-4724 NN denotes expression
T16462 4725-4727 IN denotes as
T16463 4728-4736 VB denotes examined
T16464 4737-4739 IN denotes in
T16465 4740-4744 DT denotes this
T16466 4745-4750 NN denotes study
T16467 4750-4751 -COMMA- denotes ,
T16468 4752-4754 PRP denotes we
T16469 4755-4758 VB denotes are
T16470 4759-4769 VB denotes evaluating
T16471 4770-4773 DT denotes the
T16472 4774-4785 NN denotes possibility
T16473 4786-4790 IN denotes that
T16474 4791-4805 JJ denotes PKCα-regulated
T16475 4806-4811 NN denotes NF-κB
T16476 4812-4820 NN denotes activity
T16477 4821-4832 VB denotes upregulates
T16478 4833-4843 JJ denotes additional
T16479 4844-4858 JJ denotes anti-apoptotic
T16480 4859-4864 NN denotes genes
T16481 4865-4867 IN denotes in
T16482 4868-4870 DT denotes an
T16483 4871-4886 JJ denotes M-CSF-dependent
T16484 4887-4894 NN denotes fashion
T16485 4895-4897 TO denotes to
T16486 4898-4906 VB denotes modulate
T16487 4907-4911 NN denotes cell
T16488 4912-4920 NN denotes survival
T16489 4922-4925 DT denotes The
T16490 4926-4929 NN denotes use
T16491 4930-4932 IN denotes of
T16492 4933-4943 NN denotes inhibitors
T16493 4944-4947 CC denotes and
T16494 4948-4953 NN denotes siRNA
T16495 4954-4956 IN denotes in
T16496 4957-4960 PRP-DOLLAR- denotes our
T16497 4961-4966 NN denotes study
T16498 4967-4970 VB denotes has
T16499 4971-4974 RB denotes not
T16500 4975-4980 VB denotes ruled
T16501 4981-4984 RP denotes out
T16502 4985-4989 IN denotes that
T16503 4990-4995 JJ denotes other
T16504 4996-5008 JJ denotes conventional
T16505 5009-5013 NN denotes PKCs
T16506 5014-5019 MD denotes might
T16507 5020-5024 RB denotes also
T16508 5025-5027 VB denotes be
T16509 5028-5037 JJ denotes important
T16510 5038-5040 IN denotes in
T16511 5041-5054 JJ denotes M-CSF-induced
T16512 5055-5060 NN denotes NF-κB
T16513 5061-5071 NN denotes activation
T16514 5072-5075 CC denotes and
T16515 5076-5086 NN denotes macrophage
T16516 5087-5095 NN denotes survival
T16517 5097-5099 IN denotes In
T16518 5100-5108 NN denotes contrast
T16519 5109-5111 TO denotes to
T16520 5112-5115 DT denotes the
T16521 5116-5123 NN denotes actions
T16522 5124-5126 IN denotes of
T16523 5127-5131 NN denotes PKCα
T16524 5132-5142 NN denotes activation
T16525 5143-5145 IN denotes of
T16526 5146-5151 JJ denotes other
T16527 5152-5164 JJ denotes conventional
T16528 5165-5168 NN denotes PKC
T16529 5169-5177 NN denotes isoforms
T16530 5177-5178 -COMMA- denotes ,
T16531 5179-5183 IN denotes like
T16532 5184-5193 NN denotes PKCβI/βII
T16533 5193-5194 -COMMA- denotes ,
T16534 5195-5201 VB denotes appear
T16535 5202-5211 JJ denotes necessary
T16536 5212-5215 IN denotes for
T16537 5216-5226 NN denotes macrophage
T16538 5227-5236 NN denotes apoptosis
T16539 5238-5241 DT denotes The
T16540 5242-5251 NN denotes PKCβI/βII
T16541 5252-5260 NN denotes isoforms
T16542 5261-5264 VB denotes are
T16543 5265-5274 VB denotes expressed
T16544 5275-5277 IN denotes in
T16545 5278-5287 JJ denotes apoptotic
T16546 5288-5292 NN denotes U937
T16547 5293-5307 JJ denotes myelomonocytic
T16548 5308-5313 NN denotes cells
T16549 5314-5315 -LRB- denotes [
T16550 5315-5317 CD denotes 45
T16551 5317-5318 -RRB- denotes ]
T16552 5320-5323 DT denotes The
T16553 5324-5329 JJ denotes human
T16554 5330-5337 JJ denotes myeloid
T16555 5338-5342 NN denotes cell
T16556 5343-5347 NN denotes line
T16557 5348-5354 NN denotes HL-525
T16558 5355-5360 WDT denotes which
T16559 5361-5363 VB denotes is
T16560 5364-5370 JJ denotes devoid
T16561 5371-5373 IN denotes of
T16562 5374-5384 JJ denotes endogenous
T16563 5385-5391 NN denotes PKCβII
T16564 5392-5394 VB denotes is
T16565 5395-5404 JJ denotes resistant
T16566 5405-5407 TO denotes to
T16567 5408-5420 JJ denotes TNFα-induced
T16568 5421-5430 NN denotes apoptosis
T16569 5431-5432 -LRB- denotes [
T16570 5432-5434 CD denotes 46
T16571 5434-5435 -RRB- denotes ]
T16572 5437-5450 NN denotes Re-expression
T16573 5451-5453 IN denotes of
T16574 5454-5460 NN denotes PKCβII
T16575 5461-5463 IN denotes in
T16576 5464-5470 NN denotes HL-525
T16577 5471-5476 NN denotes cells
T16578 5477-5485 VB denotes restores
T16579 5486-5491 PRP-DOLLAR- denotes their
T16580 5492-5506 NN denotes susceptibility
T16581 5507-5509 TO denotes to
T16582 5510-5522 JJ denotes TNFα-induced
T16583 5523-5532 NN denotes apoptosis
T16584 5533-5541 VB denotes implying
T16585 5542-5546 IN denotes that
T16586 5547-5553 NN denotes PKCβII
T16587 5554-5556 VB denotes is
T16588 5557-5570 JJ denotes pro-apoptotic
T16589 5571-5574 CC denotes and
T16590 5575-5578 MD denotes may
T16591 5579-5581 VB denotes be
T16592 5582-5590 VB denotes required
T16593 5591-5593 TO denotes to
T16594 5594-5600 VB denotes induce
T16595 5601-5611 NN denotes macrophage
T16596 5612-5621 NN denotes apoptosis
T16597 5623-5629 JJ denotes Recent
T16598 5630-5637 NN denotes studies
T16599 5638-5650 VB denotes demonstrated
T16600 5651-5655 IN denotes that
T16601 5656-5661 NN denotes NF-κB
T16602 5662-5677 JJ denotes transcriptional
T16603 5678-5686 NN denotes activity
T16604 5687-5690 MD denotes can
T16605 5691-5693 VB denotes be
T16606 5694-5703 VB denotes regulated
T16607 5704-5706 IN denotes by
T16608 5707-5722 NN denotes phosphorylation
T16609 5723-5725 IN denotes of
T16610 5726-5729 DT denotes the
T16611 5730-5735 NN denotes NF-κB
T16612 5736-5739 NN denotes p65
T16613 5740-5747 NN denotes subunit
T16614 5748-5750 IN denotes in
T16615 5751-5754 DT denotes the
T16616 5755-5762 NN denotes absence
T16617 5763-5765 IN denotes of
T16618 5766-5770 NN denotes IκBα
T16619 5771-5782 NN denotes degradation
T16620 5783-5784 -LRB- denotes [
T16621 5784-5786 CD denotes 47
T16622 5786-5787 -RRB- denotes ]
T16623 5789-5791 IN denotes By
T16624 5792-5796 DT denotes this
T16625 5797-5804 NN denotes pathway
T16626 5804-5805 -COMMA- denotes ,
T16627 5806-5821 NN denotes phosphorylation
T16628 5822-5824 IN denotes of
T16629 5825-5830 NN denotes NF-κB
T16630 5831-5840 VB denotes regulates
T16631 5841-5844 PRP-DOLLAR- denotes its
T16632 5845-5856 NN denotes interaction
T16633 5857-5861 IN denotes with
T16634 5862-5867 JJ denotes other
T16635 5868-5878 NN denotes components
T16636 5879-5881 IN denotes of
T16637 5882-5885 DT denotes the
T16638 5886-5891 JJ denotes basal
T16639 5892-5907 JJ denotes transcriptional
T16640 5908-5917 NN denotes machinery
T16641 5918-5925 IN denotes without
T16642 5926-5935 VB denotes affecting
T16643 5936-5939 PRP-DOLLAR- denotes its
T16644 5940-5950 NN denotes capability
T16645 5951-5953 TO denotes to
T16646 5954-5958 VB denotes bind
T16647 5959-5962 NN denotes DNA
T16648 5963-5964 -LRB- denotes [
T16649 5964-5966 CD denotes 21
T16650 5966-5967 -RRB- denotes ]
T16651 5969-5974 IN denotes Since
T16652 5975-5980 NN denotes NF-κB
T16653 5981-5984 MD denotes can
T16654 5985-5989 VB denotes bind
T16655 5990-5993 DT denotes the
T16656 5994-6003 NN denotes promoters
T16657 6004-6006 IN denotes of
T16658 6007-6015 JJ denotes numerous
T16659 6016-6020 NN denotes gene
T16660 6021-6028 NN denotes targets
T16661 6028-6029 -COMMA- denotes ,
T16662 6030-6048 JJ denotes post-translational
T16663 6049-6061 NN denotes modification
T16664 6062-6064 IN denotes of
T16665 6065-6070 NN denotes NF-κB
T16666 6071-6074 NN denotes p65
T16667 6075-6078 MD denotes may
T16668 6079-6085 VB denotes affect
T16669 6086-6089 PRP-DOLLAR- denotes its
T16670 6090-6101 NN denotes interaction
T16671 6102-6106 IN denotes with
T16672 6107-6112 JJ denotes other
T16673 6113-6121 NN denotes proteins
T16674 6121-6122 -COMMA- denotes ,
T16675 6123-6131 VB denotes refining
T16676 6132-6135 DT denotes the
T16677 6136-6146 NN denotes expression
T16678 6147-6149 IN denotes of
T16679 6150-6154 NN denotes gene
T16680 6155-6162 NN denotes targets
T16681 6164-6166 PRP denotes We
T16682 6167-6170 VB denotes did
T16683 6171-6174 RB denotes not
T16684 6175-6179 VB denotes find
T16685 6180-6184 DT denotes that
T16686 6185-6188 NN denotes PKC
T16687 6189-6192 VB denotes was
T16688 6193-6201 VB denotes involved
T16689 6202-6204 IN denotes in
T16690 6205-6209 NN denotes IκBα
T16691 6210-6221 NN denotes degradation
T16692 6222-6224 CC denotes or
T16693 6225-6230 NN denotes NF-κB
T16694 6231-6234 NN denotes p65
T16695 6235-6242 JJ denotes nuclear
T16696 6243-6256 NN denotes translocation
T16697 6257-6264 VB denotes induced
T16698 6265-6267 IN denotes by
T16699 6268-6273 NN denotes M-CSF
T16700 6273-6274 -COMMA- denotes ,
T16701 6275-6278 CC denotes but
T16702 6279-6283 IN denotes that
T16703 6284-6297 JJ denotes M-CSF-induced
T16704 6298-6313 NN denotes phosphorylation
T16705 6314-6316 IN denotes of
T16706 6317-6322 NN denotes NF-κB
T16707 6323-6326 NN denotes p65
T16708 6327-6329 IN denotes at
T16709 6330-6336 NN denotes Ser276
T16710 6337-6340 VB denotes was
T16711 6341-6353 RB denotes dramatically
T16712 6354-6361 VB denotes reduced
T16713 6362-6364 IN denotes by
T16714 6365-6368 DT denotes the
T16715 6369-6381 JJ denotes conventional
T16716 6382-6385 NN denotes PKC
T16717 6386-6395 NN denotes inhibitor
T16718 6396-6399 CC denotes and
T16719 6400-6406 NN denotes kinase
T16720 6407-6416 JJ denotes deficient
T16721 6417-6421 NN denotes PKCα
T16722 6422-6425 CC denotes and
T16723 6426-6428 IN denotes by
T16724 6429-6434 NN denotes siRNA
T16725 6435-6442 IN denotes towards
T16726 6443-6447 NN denotes PKCα
T16727 6449-6456 JJ denotes Current
T16728 6457-6464 NN denotes studies
T16729 6465-6468 VB denotes are
T16730 6469-6477 JJ denotes underway
T16731 6478-6480 TO denotes to
T16732 6481-6490 VB denotes delineate
T16733 6491-6494 DT denotes the
T16734 6495-6502 NN denotes protein
T16735 6503-6512 NN denotes complexes
T16736 6513-6519 VB denotes formed
T16737 6520-6522 IN denotes by
T16738 6523-6532 VB denotes activated
T16739 6533-6538 NN denotes NF-κB
T16740 6539-6542 CC denotes and
T16741 6543-6548 JJ denotes other
T16742 6549-6564 JJ denotes transcriptional
T16743 6565-6578 NN denotes co-activators
T16744 6579-6581 IN denotes in
T16745 6582-6590 NN denotes response
T16746 6591-6593 TO denotes to
T16747 6594-6599 NN denotes M-CSF
T16748 6600-6603 CC denotes and
T16749 6604-6607 NN denotes PKC
T16750 6608-6618 NN denotes activation
T16751 6620-6628 RB denotes Recently
T16752 6629-6636 NN denotes studies
T16753 6637-6646 VB denotes indicated
T16754 6647-6651 IN denotes that
T16755 6652-6655 DT denotes the
T16756 6656-6669 JJ denotes non-canonical
T16757 6670-6677 NN denotes pathway
T16758 6678-6681 VB denotes was
T16759 6682-6691 VB denotes activated
T16760 6692-6698 IN denotes during
T16761 6699-6704 JJ denotes human
T16762 6705-6724 JJ denotes monocyte-macrophage
T16763 6725-6740 NN denotes differentiation
T16764 6741-6742 -LRB- denotes [
T16765 6742-6744 CD denotes 48
T16766 6744-6745 -RRB- denotes ]
T16767 6747-6753 IN denotes During
T16768 6754-6758 DT denotes this
T16769 6759-6766 NN denotes process
T16770 6766-6767 -COMMA- denotes ,
T16771 6768-6778 NN denotes expression
T16772 6779-6781 IN denotes of
T16773 6782-6786 NN denotes IKKα
T16774 6787-6792 IN denotes among
T16775 6793-6798 JJ denotes other
T16776 6799-6807 NN denotes proteins
T16777 6807-6808 -COMMA- denotes ,
T16778 6809-6811 VB denotes is
T16779 6812-6820 VB denotes elevated
T16780 6821-6828 VB denotes leading
T16781 6829-6831 TO denotes to
T16782 6832-6841 VB denotes increased
T16783 6842-6845 NN denotes p52
T16784 6846-6851 NN denotes NF-κB
T16785 6852-6853 -LRB- denotes (
T16786 6853-6857 NN denotes relB
T16787 6857-6858 -RRB- denotes )
T16788 6859-6869 NN denotes expression
T16789 6870-6877 IN denotes through
T16790 6878-6885 JJ denotes partial
T16791 6886-6897 JJ denotes proteolytic
T16792 6898-6909 NN denotes degradation
T16793 6910-6912 IN denotes of
T16794 6913-6916 DT denotes the
T16795 6917-6921 NN denotes p100
T16796 6922-6927 NN denotes NF-κB
T16797 6928-6935 NN denotes protein
T16798 6937-6941 RB denotes Thus
T16799 6941-6942 -COMMA- denotes ,
T16800 6943-6945 PRP denotes it
T16801 6946-6948 VB denotes is
T16802 6949-6957 JJ denotes possible
T16803 6958-6962 IN denotes that
T16804 6963-6968 NN denotes M-CSF
T16805 6969-6978 VB denotes regulates
T16806 6979-6987 NN denotes monocyte
T16807 6988-6996 NN denotes survival
T16808 6997-7004 IN denotes through
T16809 7005-7009 CC denotes both
T16810 7010-7013 DT denotes the
T16811 7014-7023 JJ denotes canonical
T16812 7024-7027 CC denotes and
T16813 7028-7041 JJ denotes non-canonical
T16814 7042-7047 NN denotes NF-κB
T16815 7048-7056 NN denotes pathways
T16816 7056-7057 -COMMA- denotes ,
T16817 7058-7063 WDT denotes which
T16818 7064-7068 MD denotes will
T16819 7069-7071 VB denotes be
T16820 7072-7073 DT denotes a
T16821 7074-7079 NN denotes focus
T16822 7080-7082 IN denotes in
T16823 7083-7089 JJ denotes future
T16824 7090-7098 NN denotes research
T16825 7100-7102 PRP denotes We
T16826 7103-7113 RB denotes previously
T16827 7114-7120 VB denotes showed
T16828 7121-7125 IN denotes that
T16829 7126-7131 NN denotes M-CSF
T16830 7132-7139 VB denotes reduced
T16831 7140-7149 NN denotes caspase-3
T16832 7150-7153 CC denotes and
T16833 7154-7156 CD denotes -9
T16834 7157-7165 NN denotes activity
T16835 7166-7169 CC denotes and
T16836 7170-7179 VB denotes prevented
T16837 7180-7188 NN denotes monocyte
T16838 7189-7198 NN denotes apoptosis
T16839 7199-7200 -LRB- denotes [
T16840 7200-7201 CD denotes 3
T16841 7201-7202 -RRB- denotes ]
T16842 7204-7208 DT denotes This
T16843 7209-7214 NN denotes study
T16844 7215-7222 VB denotes reveals
T16845 7223-7227 IN denotes that
T16846 7228-7237 NN denotes treatment
T16847 7238-7240 IN denotes of
T16848 7241-7250 NN denotes monocytes
T16849 7251-7255 IN denotes with
T16850 7256-7268 JJ denotes conventional
T16851 7269-7272 NN denotes PKC
T16852 7273-7283 NN denotes inhibitors
T16853 7283-7284 -COMMA- denotes ,
T16854 7285-7287 CC denotes or
T16855 7288-7302 NN denotes overexpression
T16856 7303-7305 IN denotes of
T16857 7306-7322 JJ denotes kinase-deficient
T16858 7323-7327 NN denotes PKCα
T16859 7328-7335 VB denotes blocked
T16860 7336-7349 JJ denotes M-CSF-induced
T16861 7350-7354 NN denotes cell
T16862 7355-7363 NN denotes survival
T16863 7365-7368 PRP-DOLLAR- denotes Our
T16864 7369-7373 NN denotes data
T16865 7374-7382 VB denotes revealed
T16866 7383-7387 IN denotes that
T16867 7388-7400 JJ denotes conventional
T16868 7401-7405 NN denotes PKCs
T16869 7406-7409 VB denotes are
T16870 7410-7418 RB denotes upstream
T16871 7419-7421 IN denotes of
T16872 7422-7427 NN denotes NF-κB
T16873 7428-7438 NN denotes activation
T16874 7439-7441 IN denotes in
T16875 7442-7450 NN denotes response
T16876 7451-7453 TO denotes to
T16877 7454-7459 NN denotes M-CSF
T16878 7460-7463 CC denotes and
T16879 7464-7471 VB denotes mediate
T16880 7472-7490 JJ denotes post-translational
T16881 7491-7501 NN denotes activation
T16882 7502-7504 IN denotes of
T16883 7505-7510 NN denotes NF-κB
T16884 7511-7514 NN denotes p65
T16885 7515-7517 IN denotes by
T16886 7518-7533 VB denotes phosphorylating
T16887 7534-7540 NN denotes Ser276
T16888 7541-7543 TO denotes to
T16889 7544-7552 VB denotes regulate
T16890 7553-7557 NN denotes gene
T16891 7558-7571 NN denotes transcription
T16892 7572-7575 CC denotes and
T16893 7576-7580 NN denotes cell
T16894 7581-7589 NN denotes survival
T16895 7591-7595 RB denotes Thus
T16896 7595-7596 -COMMA- denotes ,
T16897 7597-7600 PRP-DOLLAR- denotes our
T16898 7601-7612 NN denotes observation
T16899 7613-7616 MD denotes may
T16900 7617-7624 VB denotes provide
T16901 7625-7632 NN denotes insight
T16902 7633-7635 IN denotes in
T16903 7636-7645 JJ denotes potential
T16904 7646-7657 JJ denotes therapeutic
T16905 7658-7665 NN denotes targets
T16906 7666-7669 IN denotes for
T16907 7670-7682 JJ denotes inflammatory
T16908 7683-7691 NN denotes diseases
T26865 1944-1952 VB denotes Proposed
T26866 1953-1958 NN denotes model
T26867 1959-1962 IN denotes for
T26868 1963-1976 JJ denotes M-CSF-induced
T26869 1977-1985 NN denotes monocyte
T26870 1986-1994 NN denotes survival
T26871 1995-1998 IN denotes via
T26872 1999-2002 NN denotes PKC
T26873 2003-2013 NN denotes regulation
T26874 2014-2016 IN denotes by
T26875 2017-2027 VB denotes activating
T26876 2028-2033 NN denotes NF-κB
T26877 2034-2037 NN denotes p65
T26878 2038-2053 NN denotes phosphorylation
T26879 2054-2056 IN denotes at
T26880 2057-2063 NN denotes Ser276
T15771 233-244 VB denotes translocate
R11830 T15748 T15747 arg1Of signaling,intracellular
R11831 T15748 T15749 arg1Of signaling,","
R11832 T15749 T15752 arg1Of ",",","
R11833 T15751 T15749 arg2Of response,","
R11834 T15751 T15750 arg1Of response,stress
R11835 T15752 T15754 arg1Of ",",","
R11836 T15753 T15752 arg2Of proliferation,","
R11837 T15754 T15756 arg1Of ",",","
R11838 T15755 T15754 arg2Of survival,","
R11839 T15756 T15758 arg1Of ",",and
R11840 T15757 T15756 arg2Of differentiation,","
R11841 T15758 T15746 arg2Of and,regulating
R11842 T15759 T15758 arg2Of inflammation,and
R11843 T15759 T15760 arg1Of inflammation,[
R11844 T15761 T15760 arg2Of 8,[
R11845 T15762 T15760 arg3Of ],[
R11846 T15764 T15763 arg1Of regulate,To
R11847 T15766 T15764 arg2Of transcription,regulate
R11848 T15766 T15765 arg1Of transcription,gene
R11849 T15770 T15764 arg1Of heterodimers,regulate
R11850 T15770 T15768 arg1Of heterodimers,NF-κB
R11851 T15770 T15769 arg1Of heterodimers,p50/p65
R11852 T15770 T15771 arg1Of heterodimers,translocate
R11853 T15771 T15772 arg1Of translocate,to
R11854 T15771 T15775 arg1Of translocate,from
R11855 T15771 T15778 arg1Of translocate,","
R11856 T15774 T15772 arg2Of nucleus,to
R11857 T15774 T15773 arg1Of nucleus,the
R11858 T15777 T15775 arg2Of cytoplasm,from
R11859 T15777 T15776 arg1Of cytoplasm,the
R11860 T15778 T15763 modOf ",",To
R11861 T15778 T15767 arg1Of ",",","
R11862 T15782 T15781 arg1Of translocation,their
R11863 T15782 T15783 arg1Of translocation,is
R11864 T15782 T15785 arg1Of translocation,sufficient
R11865 T15783 T15778 arg2Of is,","
R11866 T15783 T15779 arg1Of is,however
R11867 T15783 T15780 arg1Of is,","
R11868 T15783 T15784 arg1Of is,not
R11869 T15783 T15786 modOf is,to
R11870 T15785 T15783 arg2Of sufficient,is
R11871 T15787 T15786 arg1Of activate,to
R11872 T15789 T15787 arg2Of transcription,activate
R11873 T15789 T15788 arg1Of transcription,gene
R11874 T15791 T15790 arg1Of modification,Post-translational
R11875 T15791 T15792 arg1Of modification,of
R11876 T15791 T15801 arg1Of modification,contributes
R11877 T15794 T15792 arg2Of heterodimers,of
R11878 T15794 T15793 arg1Of heterodimers,NF-κB
R11879 T15794 T15796 arg1Of heterodimers,as
R11880 T15796 T15795 arg1Of as,such
R11881 T15797 T15798 arg1Of phosphorylation,or
R11882 T15798 T15796 arg2Of or,as
R11883 T15799 T15798 arg2Of acetylation,or
R11884 T15801 T15800 arg1Of contributes,also
R11885 T15801 T15802 arg1Of contributes,to
R11886 T15801 T15809 arg1Of contributes,","
R11887 T15801 T15810 arg1Of contributes,[
R11888 T15801 T15813 arg1Of contributes,","
R11889 T15801 T15814 arg1Of contributes,[
R11890 T15805 T15802 arg2Of activity,to
R11891 T15805 T15803 arg1Of activity,its
R11892 T15805 T15804 arg1Of activity,transcriptional
R11893 T15805 T15806 arg1Of activity,[
R11894 T15807 T15806 arg2Of 41,[
R11895 T15808 T15806 arg3Of ],[
R11896 T15811 T15810 arg2Of 42,[
R11897 T15812 T15810 arg3Of ],[
R11898 T15815 T15814 arg2Of 43,[
R11899 T15816 T15814 arg3Of ],[
R11900 T15818 T15820 arg1Of NF-κB,translocates
R11901 T15818 T15831 arg1Of NF-κB,activates
R11902 T15820 T15821 arg1Of translocates,to
R11903 T15820 T15824 arg1Of translocates,in
R11904 T15820 T15830 arg1Of translocates,and
R11905 T15823 T15821 arg2Of nucleus,to
R11906 T15823 T15822 arg1Of nucleus,the
R11907 T15826 T15824 arg2Of lineage,in
R11908 T15826 T15825 arg1Of lineage,monocytic
R11909 T15826 T15827 arg1Of lineage,[
R11910 T15828 T15827 arg2Of 13,[
R11911 T15829 T15827 arg3Of ],[
R11912 T15830 T15817 arg2Of and,Because
R11913 T15830 T15819 arg1Of and,constitutively
R11914 T15831 T15830 arg2Of activates,and
R11915 T15833 T15834 arg1Of transcription,and
R11916 T15834 T15831 arg2Of and,activates
R11917 T15834 T15832 arg1Of and,gene
R11918 T15834 T15836 arg1Of and,in
R11919 T15835 T15834 arg2Of survival,and
R11920 T15838 T15836 arg2Of macrophages,in
R11921 T15838 T15837 arg1Of macrophages,murine
R11922 T15838 T15839 arg1Of macrophages,[
R11923 T15840 T15839 arg2Of 11,[
R11924 T15841 T15839 arg3Of ],[
R11925 T15843 T15844 arg1Of we,sought
R11926 T15843 T15846 arg1Of we,determine
R11927 T15844 T15817 arg1Of sought,Because
R11928 T15844 T15842 arg1Of sought,","
R11929 T15846 T15844 arg2Of determine,sought
R11930 T15846 T15845 arg1Of determine,to
R11931 T15847 T15846 arg2Of how,determine
R11932 T15848 T15849 arg1Of M-CSF,affected
R11933 T15849 T15847 arg1Of affected,how
R11934 T15852 T15849 arg2Of activity,affected
R11935 T15852 T15850 arg1Of activity,NF-κB
R11936 T15852 T15851 arg1Of activity,transcriptional
R11937 T15852 T15853 arg1Of activity,in
R11938 T15852 T15857 arg1Of activity,whether
R11939 T15853 T15856 arg1Of in,and
R11940 T15855 T15853 arg2Of MDMs,in
R11941 T15855 T15854 arg1Of MDMs,human
R11942 T15857 T15856 arg2Of whether,and
R11943 T15859 T15858 arg1Of activation,this
R11944 T15859 T15860 arg1Of activation,regulated
R11945 T15860 T15857 arg2Of regulated,whether
R11946 T15862 T15860 arg2Of survival,regulated
R11947 T15862 T15861 arg1Of survival,their
R11948 T15865 T15863 arg1Of study,The
R11949 T15865 T15864 arg1Of study,present
R11950 T15865 T15866 arg1Of study,demonstrated
R11951 T15868 T15869 arg1Of M-CSF,stimulated
R11952 T15869 T15866 arg2Of stimulated,demonstrated
R11953 T15869 T15867 arg1Of stimulated,that
R11954 T15869 T15872 arg1Of stimulated,upstream
R11955 T15871 T15869 arg2Of kinase,stimulated
R11956 T15871 T15870 arg1Of kinase,PKCα
R11957 T15872 T15873 arg1Of upstream,of
R11958 T15876 T15873 arg2Of activity,of
R11959 T15876 T15874 arg1Of activity,NF-κB
R11960 T15876 T15875 arg1Of activity,transcriptional
R11961 T15876 T15877 arg1Of activity,in
R11962 T15880 T15878 arg1Of MDMs,primary
R11963 T15880 T15879 arg1Of MDMs,human
R11964 T15880 T15881 arg1Of MDMs,and
R11965 T15881 T15877 arg2Of and,in
R11966 T15884 T15881 arg2Of cells,and
R11967 T15884 T15882 arg1Of cells,RAW
R11968 T15884 T15883 arg1Of cells,264.7
R11969 T15885 T15886 arg1Of We,showed
R11970 T15886 T15898 arg1Of showed,or
R11971 T15887 T15888 arg1Of inhibition,of
R11972 T15887 T15891 arg1Of inhibition,by
R11973 T15887 T15894 arg1Of inhibition,","
R11974 T15890 T15888 arg2Of PKCs,of
R11975 T15890 T15889 arg1Of PKCs,conventional
R11976 T15893 T15891 arg2Of inhibitors,by
R11977 T15893 T15892 arg1Of inhibitors,PKC
R11978 T15894 T15886 arg2Of ",",showed
R11979 T15897 T15894 arg2Of PKCα,","
R11980 T15897 T15895 arg1Of PKCα,kinase
R11981 T15897 T15896 arg1Of PKCα,deficient
R11982 T15900 T15899 arg1Of siRNA,PKCα
R11983 T15900 T15901 arg1Of siRNA,blocked
R11984 T15901 T15898 arg2Of blocked,or
R11985 T15904 T15903 arg1Of survival,cell
R11986 T15904 T15905 arg1Of survival,and
R11987 T15905 T15901 arg2Of and,blocked
R11988 T15905 T15902 arg1Of and,M-CSF-induced
R11989 T15908 T15905 arg2Of expression,and
R11990 T15908 T15906 arg1Of expression,NF-κB-regulated
R11991 T15908 T15907 arg1Of expression,gene
R11992 T15910 T15909 arg1Of block,This
R11993 T15910 T15911 arg1Of block,correlated
R11994 T15911 T15912 arg1Of correlated,with
R11995 T15914 T15912 arg2Of reduction,with
R11996 T15914 T15913 arg1Of reduction,a
R11997 T15914 T15915 arg1Of reduction,in
R11998 T15917 T15915 arg2Of phosphorylation,in
R11999 T15917 T15916 arg1Of phosphorylation,M-CSF-induced
R12000 T15917 T15918 arg1Of phosphorylation,of
R12001 T15920 T15918 arg2Of p65,of
R12002 T15920 T15919 arg1Of p65,NF-κB
R12003 T15920 T15921 arg1Of p65,at
R12004 T15922 T15921 arg2Of Ser276,at
R12005 T15923 T15924 arg1Of Consistent,with
R12006 T15926 T15924 arg2Of findings,with
R12007 T15926 T15925 arg1Of findings,these
R12008 T15931 T15927 arg1Of constructs,the
R12009 T15931 T15928 arg1Of constructs,dominant
R12010 T15931 T15929 arg1Of constructs,negative
R12011 T15931 T15930 arg1Of constructs,PKCα
R12012 T15931 T15933 arg1Of constructs,inhibited
R12013 T15933 T15923 arg1Of inhibited,Consistent
R12014 T15933 T15932 arg1Of inhibited,also
R12015 T15933 T15937 arg1Of inhibited,at
R12016 T15933 T15941 arg1Of inhibited,at
R12017 T15936 T15933 arg2Of phosphorylation,inhibited
R12018 T15936 T15934 arg1Of phosphorylation,NF-κB
R12019 T15936 T15935 arg1Of phosphorylation,p65
R12020 T15937 T15939 arg1Of at,but
R12021 T15938 T15937 arg2Of Ser276,at
R12022 T15941 T15939 arg2Of at,but
R12023 T15941 T15940 arg1Of at,not
R12024 T15942 T15941 arg2Of Ser536,at
R12025 T15942 T15943 arg1Of Ser536,resulting
R12026 T15943 T15944 arg1Of resulting,in
R12027 T15948 T15945 arg2Of activation,reduced
R12028 T15948 T15946 arg1Of activation,NF-κB
R12029 T15948 T15947 arg1Of activation,transcriptional
R12030 T15948 T15949 arg1Of activation,and
R12031 T15949 T15944 arg2Of and,in
R12032 T15952 T15949 arg2Of survival,and
R12033 T15952 T15950 arg1Of survival,M-CSF-induced
R12034 T15952 T15951 arg1Of survival,MDM
R12035 T15957 T15953 arg1Of model,A
R12036 T15957 T15954 arg2Of model,simplified
R12037 T15957 T15955 arg2Of model,proposed
R12038 T15957 T15956 arg1Of model,cartoon
R12039 T15957 T15958 arg1Of model,in
R12040 T15957 T15961 arg1Of model,demonstrates
R12041 T15959 T15958 arg2Of Figure,in
R12042 T15959 T15960 arg1Of Figure,9
R12043 T15963 T15964 arg1Of M-CSF,induced
R12044 T15965 T15964 arg2Of monocytes,induced
R12045 T15966 T15967 arg1Of survival,is
R12046 T15966 T15968 arg2Of survival,regulated
R12047 T15968 T15961 arg2Of regulated,demonstrates
R12048 T15968 T15962 arg1Of regulated,that
R12049 T15968 T15964 arg3Of regulated,induced
R12050 T15968 T15967 arg2Of regulated,is
R12051 T15968 T15969 arg1Of regulated,by
R12052 T15970 T15969 arg2Of activating,by
R12053 T15970 T15974 arg1Of activating,at
R12054 T15970 T15976 arg1Of activating,via
R12055 T15973 T15970 arg2Of phosphorylation,activating
R12056 T15973 T15971 arg1Of phosphorylation,NF-κB
R12057 T15973 T15972 arg1Of phosphorylation,p65
R12058 T15975 T15974 arg2Of Ser276,at
R12059 T15977 T15976 arg2Of PKC,via
R12060 T15986 T15980 arg2Of line,in
R12061 T15986 T15981 arg1Of line,a
R12062 T15986 T15982 arg1Of line,NF-κB
R12063 T15986 T15983 arg1Of line,p65−/−
R12064 T15986 T15984 arg1Of line,fibroblast
R12065 T15986 T15985 arg1Of line,cell
R12066 T15988 T15989 arg1Of we,confirmed
R12067 T15989 T15978 arg1Of confirmed,Finally
R12068 T15989 T15979 arg1Of confirmed,","
R12069 T15989 T15980 arg1Of confirmed,in
R12070 T15989 T15987 arg1Of confirmed,","
R12071 T15993 T15991 arg1Of residue,the
R12072 T15993 T15992 arg1Of residue,Ser276
R12073 T15993 T15994 arg1Of residue,of
R12074 T15993 T15997 arg1Of residue,is
R12075 T15993 T15998 arg1Of residue,important
R12076 T15993 T16000 arg1Of residue,essential
R12077 T15996 T15994 arg2Of p65,of
R12078 T15996 T15995 arg1Of p65,NF-κB
R12079 T15997 T15989 arg2Of is,confirmed
R12080 T15997 T15990 arg1Of is,that
R12081 T15998 T15999 arg1Of important,and
R12082 T15999 T15997 arg2Of and,is
R12083 T15999 T16001 arg1Of and,for
R12084 T16000 T15999 arg2Of essential,and
R12085 T16003 T16001 arg2Of modulation,for
R12086 T16003 T16002 arg1Of modulation,PKC
R12087 T16003 T16004 arg1Of modulation,of
R12088 T16006 T16004 arg2Of activity,of
R12089 T16006 T16005 arg1Of activity,NF-κB
R12090 T16008 T16007 arg1Of compelling,More
R12091 T16008 T16009 arg2Of compelling,is
R12092 T16011 T16012 arg1Of we,observed
R12093 T16012 T16008 arg1Of observed,compelling
R12094 T16012 T16009 arg1Of observed,is
R12095 T16012 T16010 arg1Of observed,that
R12096 T16012 T16021 arg1Of observed,in
R12097 T16015 T16012 arg2Of regulation,observed
R12098 T16015 T16013 arg1Of regulation,a
R12099 T16015 T16014 arg1Of regulation,similar
R12100 T16015 T16016 arg1Of regulation,between
R12101 T16020 T16016 arg2Of lineages,between
R12102 T16020 T16017 arg1Of lineages,two
R12103 T16020 T16018 arg1Of lineages,different
R12104 T16020 T16019 arg1Of lineages,cell
R12105 T16023 T16021 arg2Of study,in
R12106 T16023 T16022 arg1Of study,our
R12107 T16025 T16024 arg1Of modification,Post-translational
R12108 T16025 T16026 arg1Of modification,of
R12109 T16025 T16029 arg1Of modification,regulates
R12110 T16028 T16026 arg2Of p65,of
R12111 T16028 T16027 arg1Of p65,NF-κB
R12112 T16029 T16035 arg1Of regulates,on
R12113 T16031 T16032 arg1Of activating,or
R12114 T16033 T16032 arg2Of repressing,or
R12115 T16034 T16029 arg2Of effects,regulates
R12116 T16034 T16030 arg1Of effects,its
R12117 T16034 T16031 arg1Of effects,activating
R12118 T16034 T16033 arg1Of effects,repressing
R12119 T16037 T16035 arg2Of expression,on
R12120 T16037 T16036 arg1Of expression,gene
R12121 T16040 T16038 arg2Of seven,Among
R12122 T16040 T16039 arg1Of seven,the
R12123 T16040 T16041 arg2Of seven,reported
R12124 T16041 T16043 arg1Of reported,NF-κB
R12125 T16043 T16042 arg1Of NF-κB,putative
R12126 T16046 T16044 arg1Of sites,p65
R12127 T16046 T16045 arg1Of sites,phosphorylation
R12128 T16046 T16047 arg1Of sites,","
R12129 T16047 T16052 arg1Of ",",","
R12130 T16051 T16047 arg2Of translocation,","
R12131 T16051 T16048 arg1Of translocation,five
R12132 T16051 T16049 arg1Of translocation,increase
R12133 T16051 T16050 arg1Of translocation,nuclear
R12134 T16052 T16055 arg1Of ",",and
R12135 T16054 T16052 arg2Of binding,","
R12136 T16054 T16053 arg1Of binding,DNA
R12137 T16055 T16038 arg1Of and,Among
R12138 T16058 T16055 arg2Of activity,and
R12139 T16058 T16056 arg1Of activity,NF-κB
R12140 T16058 T16057 arg1Of activity,transcriptional
R12141 T16058 T16059 arg1Of activity,[
R12142 T16060 T16059 arg2Of 17,[
R12143 T16061 T16059 arg3Of ],[
R12144 T16062 T16063 arg1Of Similar,to
R12145 T16065 T16063 arg2Of finding,to
R12146 T16065 T16064 arg1Of finding,our
R12147 T16069 T16067 arg1Of al.,Zhong
R12148 T16069 T16068 arg1Of al.,et
R12149 T16069 T16070 arg1Of al.,found
R12150 T16070 T16062 arg1Of found,Similar
R12151 T16070 T16066 arg1Of found,","
R12152 T16073 T16072 arg2Of response,in
R12153 T16073 T16074 arg1Of response,to
R12154 T16075 T16074 arg2Of LPS,to
R12155 T16078 T16077 arg1Of p65,NF-κB
R12156 T16078 T16079 arg1Of p65,is
R12157 T16078 T16080 arg2Of p65,phosphorylated
R12158 T16080 T16070 arg2Of phosphorylated,found
R12159 T16080 T16071 arg1Of phosphorylated,that
R12160 T16080 T16072 arg1Of phosphorylated,in
R12161 T16080 T16076 arg1Of phosphorylated,","
R12162 T16080 T16079 arg2Of phosphorylated,is
R12163 T16080 T16081 arg1Of phosphorylated,at
R12164 T16080 T16087 arg1Of phosphorylated,by
R12165 T16080 T16093 arg1Of phosphorylated,[
R12166 T16084 T16083 arg1Of conserved,highly
R12167 T16086 T16081 arg2Of residue,at
R12168 T16086 T16082 arg1Of residue,the
R12169 T16086 T16084 arg1Of residue,conserved
R12170 T16086 T16085 arg1Of residue,Ser276
R12171 T16090 T16087 arg2Of subunit,by
R12172 T16090 T16088 arg1Of subunit,the
R12173 T16090 T16089 arg1Of subunit,catalytic
R12174 T16090 T16091 arg1Of subunit,of
R12175 T16092 T16091 arg2Of PKA,of
R12176 T16094 T16093 arg2Of 16,[
R12177 T16095 T16093 arg3Of ],[
R12178 T16097 T16096 arg2Of addition,In
R12179 T16097 T16098 arg1Of addition,to
R12180 T16099 T16098 arg2Of PKA,to
R12181 T16101 T16102 arg1Of Ser276,can
R12182 T16101 T16103 arg1Of Ser276,be
R12183 T16101 T16104 arg2Of Ser276,phosphorylated
R12184 T16104 T16096 arg1Of phosphorylated,In
R12185 T16104 T16100 arg1Of phosphorylated,","
R12186 T16104 T16102 arg2Of phosphorylated,can
R12187 T16104 T16103 arg2Of phosphorylated,be
R12188 T16104 T16107 arg1Of phosphorylated,in
R12189 T16104 T16110 arg1Of phosphorylated,upon
R12190 T16104 T16113 arg1Of phosphorylated,[
R12191 T16106 T16104 arg1Of MSK1,phosphorylated
R12192 T16106 T16105 arg2Of MSK1,by
R12193 T16109 T16107 arg2Of nucleus,in
R12194 T16109 T16108 arg1Of nucleus,the
R12195 T16112 T16110 arg2Of treatment,upon
R12196 T16112 T16111 arg1Of treatment,TNFα
R12197 T16114 T16113 arg2Of 18,[
R12198 T16115 T16113 arg3Of ],[
R12199 T16116 T16117 arg1Of Phosphorylation,of
R12200 T16116 T16120 arg1Of Phosphorylation,at
R12201 T16116 T16122 arg1Of Phosphorylation,occurs
R12202 T16119 T16117 arg2Of p65,of
R12203 T16119 T16118 arg1Of p65,NF-κB
R12204 T16121 T16120 arg2Of Ser536,at
R12205 T16122 T16123 arg1Of occurs,in
R12206 T16122 T16146 arg1Of occurs,","
R12207 T16122 T16147 arg1Of occurs,[
R12208 T16122 T16150 arg1Of occurs,","
R12209 T16122 T16151 arg1Of occurs,[
R12210 T16122 T16154 arg1Of occurs,","
R12211 T16122 T16155 arg1Of occurs,[
R12212 T16124 T16123 arg2Of response,in
R12213 T16124 T16125 arg1Of response,to
R12214 T16128 T16126 arg1Of stimuli,many
R12215 T16128 T16127 arg1Of stimuli,inflammatory
R12216 T16128 T16131 arg1Of stimuli,as
R12217 T16131 T16125 arg2Of as,to
R12218 T16131 T16129 arg1Of as,as
R12219 T16131 T16130 arg1Of as,well
R12220 T16131 T16142 arg1Of as,","
R12221 T16131 T16143 arg1Of as,[
R12222 T16132 T16133 arg1Of kinases,","
R12223 T16133 T16135 arg1Of ",",","
R12224 T16134 T16133 arg2Of IKKα,","
R12225 T16135 T16137 arg1Of ",",and
R12226 T16136 T16135 arg2Of IKKβ,","
R12227 T16137 T16131 arg2Of and,as
R12228 T16138 T16137 arg2Of RSK1,and
R12229 T16138 T16139 arg1Of RSK1,[
R12230 T16140 T16139 arg2Of 17,[
R12231 T16141 T16139 arg3Of ],[
R12232 T16144 T16143 arg2Of 18,[
R12233 T16145 T16143 arg3Of ],[
R12234 T16148 T16147 arg2Of 19,[
R12235 T16149 T16147 arg3Of ],[
R12236 T16152 T16151 arg2Of 20,[
R12237 T16153 T16151 arg3Of ],[
R12238 T16156 T16155 arg2Of 21,[
R12239 T16157 T16155 arg3Of ],[
R12240 T16161 T16160 arg2Of addition,in
R12241 T16161 T16162 arg1Of addition,to
R12242 T16163 T16162 arg2Of phosphorylating,to
R12243 T16164 T16163 arg2Of Ser276,phosphorylating
R12244 T16164 T16165 arg1Of Ser276,of
R12245 T16166 T16165 arg2Of NF-κB,of
R12246 T16169 T16168 arg1Of study,our
R12247 T16169 T16170 arg1Of study,revealed
R12248 T16170 T16158 arg1Of revealed,Notably
R12249 T16170 T16159 arg1Of revealed,","
R12250 T16170 T16160 arg1Of revealed,in
R12251 T16170 T16167 arg1Of revealed,","
R12252 T16172 T16174 arg1Of M-CSF,modulated
R12253 T16174 T16173 arg1Of modulated,also
R12254 T16174 T16184 arg1Of modulated,","
R12255 T16176 T16174 arg2Of phosphorylation,modulated
R12256 T16176 T16175 arg1Of phosphorylation,the
R12257 T16176 T16177 arg1Of phosphorylation,of
R12258 T16176 T16182 arg1Of phosphorylation,at
R12259 T16181 T16177 arg2Of subunit,of
R12260 T16181 T16178 arg1Of subunit,the
R12261 T16181 T16179 arg1Of subunit,NF-κB
R12262 T16181 T16180 arg1Of subunit,p65
R12263 T16183 T16182 arg2Of Ser536,at
R12264 T16184 T16170 arg2Of ",",revealed
R12265 T16184 T16171 arg1Of ",",that
R12266 T16188 T16187 arg1Of inhibitors,PKC
R12267 T16188 T16189 arg1Of inhibitors,or
R12268 T16189 T16194 arg1Of or,did
R12269 T16189 T16196 arg1Of or,affect
R12270 T16193 T16189 arg2Of constructs,or
R12271 T16193 T16190 arg1Of constructs,kinase
R12272 T16193 T16191 arg1Of constructs,deficient
R12273 T16193 T16192 arg1Of constructs,PKCα
R12274 T16196 T16184 arg2Of affect,","
R12275 T16196 T16185 arg1Of affect,however
R12276 T16196 T16186 arg1Of affect,","
R12277 T16196 T16194 arg2Of affect,did
R12278 T16196 T16195 arg1Of affect,not
R12279 T16199 T16196 arg2Of event,affect
R12280 T16199 T16197 arg1Of event,this
R12281 T16199 T16198 arg1Of event,phosphorylation
R12282 T16203 T16202 arg1Of constructs,mutant
R12283 T16203 T16204 arg1Of constructs,containing
R12284 T16203 T16213 arg1Of constructs,did
R12285 T16203 T16215 arg1Of constructs,reduce
R12286 T16207 T16204 arg2Of mutation,containing
R12287 T16207 T16205 arg1Of mutation,a
R12288 T16207 T16206 arg1Of mutation,point
R12289 T16207 T16208 arg1Of mutation,at
R12290 T16209 T16208 arg2Of Ser536,at
R12291 T16209 T16210 arg1Of Ser536,of
R12292 T16212 T16210 arg2Of p65,of
R12293 T16212 T16211 arg1Of p65,NF-κB
R12294 T16215 T16200 arg1Of reduce,Moreover
R12295 T16215 T16201 arg1Of reduce,","
R12296 T16215 T16213 arg2Of reduce,did
R12297 T16215 T16214 arg1Of reduce,not
R12298 T16215 T16224 arg1Of reduce,","
R12299 T16215 T16225 arg1Of reduce,while
R12300 T16217 T16215 arg2Of activity,reduce
R12301 T16217 T16216 arg1Of activity,NF-κB
R12302 T16217 T16218 arg1Of activity,in
R12303 T16219 T16218 arg2Of cells,in
R12304 T16219 T16220 arg1Of cells,lacking
R12305 T16223 T16220 arg2Of p65,lacking
R12306 T16223 T16221 arg1Of p65,endogenous
R12307 T16223 T16222 arg1Of p65,NF-κB
R12308 T16230 T16226 arg1Of construct,the
R12309 T16230 T16227 arg1Of construct,NF-κB
R12310 T16230 T16228 arg1Of construct,p65
R12311 T16230 T16229 arg1Of construct,276S/A
R12312 T16230 T16231 arg1Of construct,did
R12313 T16230 T16232 arg1Of construct,reduce
R12314 T16232 T16225 arg2Of reduce,while
R12315 T16232 T16231 arg2Of reduce,did
R12316 T16234 T16232 arg2Of activity,reduce
R12317 T16234 T16233 arg1Of activity,NF-κB
R12318 T16234 T16235 arg1Of activity,in
R12319 T16237 T16235 arg2Of cells,in
R12320 T16237 T16236 arg1Of cells,these
R12321 T16242 T16240 arg1Of modification,specific
R12322 T16242 T16241 arg1Of modification,post-translational
R12323 T16242 T16243 arg1Of modification,of
R12324 T16242 T16246 arg1Of modification,is
R12325 T16242 T16247 arg1Of modification,likely
R12326 T16242 T16249 arg1Of modification,regulate
R12327 T16245 T16243 arg2Of p65,of
R12328 T16245 T16244 arg1Of p65,NF-κB
R12329 T16246 T16238 arg1Of is,Therefore
R12330 T16246 T16239 arg1Of is,","
R12331 T16246 T16260 arg1Of is,","
R12332 T16246 T16261 arg1Of is,[
R12333 T16247 T16246 arg2Of likely,is
R12334 T16249 T16247 arg2Of regulate,likely
R12335 T16249 T16248 arg1Of regulate,to
R12336 T16249 T16252 arg1Of regulate,in
R12337 T16251 T16249 arg2Of activation,regulate
R12338 T16251 T16250 arg1Of activation,transcriptional
R12339 T16253 T16252 arg2Of response,in
R12340 T16253 T16254 arg1Of response,to
R12341 T16256 T16254 arg2Of stimuli,to
R12342 T16256 T16255 arg1Of stimuli,specific
R12343 T16256 T16257 arg1Of stimuli,[
R12344 T16258 T16257 arg2Of 15,[
R12345 T16259 T16257 arg3Of ],[
R12346 T16262 T16261 arg2Of 43,[
R12347 T16263 T16261 arg3Of ],[
R12348 T16266 T16265 arg2Of notable,is
R12349 T16268 T16269 arg1Of M-CSF,activated
R12350 T16269 T16264 arg1Of activated,It
R12351 T16269 T16265 arg1Of activated,is
R12352 T16269 T16266 arg1Of activated,notable
R12353 T16269 T16267 arg1Of activated,that
R12354 T16269 T16277 arg1Of activated,in
R12355 T16273 T16270 arg1Of phosphorylation,NF-κB
R12356 T16273 T16271 arg1Of phosphorylation,p65
R12357 T16273 T16272 arg1Of phosphorylation,Ser276
R12358 T16273 T16274 arg1Of phosphorylation,and
R12359 T16274 T16269 arg2Of and,activated
R12360 T16276 T16274 arg2Of activation,and
R12361 T16276 T16275 arg1Of activation,transcriptional
R12362 T16280 T16277 arg2Of manner,in
R12363 T16280 T16278 arg1Of manner,a
R12364 T16280 T16279 arg1Of manner,PKCα-dependent
R12365 T16281 T16282 arg1Of PKCα,is
R12366 T16284 T16282 arg2Of member,is
R12367 T16284 T16283 arg1Of member,a
R12368 T16284 T16285 arg1Of member,of
R12369 T16289 T16285 arg2Of family,of
R12370 T16289 T16286 arg1Of family,the
R12371 T16289 T16287 arg1Of family,conventional
R12372 T16289 T16288 arg1Of family,PKC
R12373 T16289 T16290 arg1Of family,of
R12374 T16292 T16290 arg2Of kinases,of
R12375 T16292 T16291 arg1Of kinases,protein
R12376 T16292 T16293 arg1Of kinases,that
R12377 T16292 T16294 arg1Of kinases,are
R12378 T16292 T16295 arg1Of kinases,critical
R12379 T16295 T16294 arg2Of critical,are
R12380 T16295 T16296 arg1Of critical,for
R12381 T16298 T16297 arg1Of growth,cell
R12382 T16298 T16299 arg1Of growth,","
R12383 T16299 T16301 arg1Of ",",and
R12384 T16300 T16299 arg2Of differentiation,","
R12385 T16301 T16296 arg2Of and,for
R12386 T16303 T16301 arg2Of death,and
R12387 T16303 T16302 arg1Of death,cell
R12388 T16304 T16306 arg1Of PKCα,modulates
R12389 T16306 T16305 arg1Of modulates,primarily
R12390 T16306 T16311 arg1Of modulates,following
R12391 T16307 T16308 arg1Of anti-apoptotic,and
R12392 T16309 T16308 arg2Of proliferation,and
R12393 T16310 T16306 arg2Of signals,modulates
R12394 T16310 T16307 arg1Of signals,anti-apoptotic
R12395 T16310 T16309 arg1Of signals,proliferation
R12396 T16313 T16311 arg2Of treatment,following
R12397 T16313 T16312 arg1Of treatment,cytokine
R12398 T16313 T16314 arg1Of treatment,in
R12399 T16317 T16314 arg2Of types,in
R12400 T16317 T16315 arg1Of types,various
R12401 T16317 T16316 arg1Of types,cell
R12402 T16317 T16318 arg1Of types,[
R12403 T16319 T16318 arg2Of 42,[
R12404 T16320 T16318 arg3Of ],[
R12405 T16321 T16322 arg1Of Expression,of
R12406 T16321 T16324 arg1Of Expression,attenuates
R12407 T16323 T16322 arg2Of PKCα,of
R12408 T16324 T16326 arg1Of attenuates,in
R12409 T16324 T16331 arg1Of attenuates,","
R12410 T16324 T16332 arg1Of attenuates,while
R12411 T16325 T16324 arg2Of apoptosis,attenuates
R12412 T16330 T16326 arg2Of types,in
R12413 T16330 T16327 arg1Of types,many
R12414 T16330 T16328 arg1Of types,different
R12415 T16330 T16329 arg1Of types,cell
R12416 T16334 T16333 arg1Of inhibition,PKCα
R12417 T16334 T16336 arg1Of inhibition,potentiates
R12418 T16336 T16332 arg2Of potentiates,while
R12419 T16336 T16335 arg1Of potentiates,generally
R12420 T16337 T16336 arg2Of apoptosis,potentiates
R12421 T16337 T16338 arg1Of apoptosis,[
R12422 T16339 T16338 arg2Of 42,[
R12423 T16340 T16338 arg3Of ],[
R12424 T16343 T16341 arg2Of studies,In
R12425 T16343 T16342 arg1Of studies,our
R12426 T16343 T16344 arg1Of studies,using
R12427 T16347 T16345 arg1Of inhibitors,conventional
R12428 T16347 T16346 arg1Of inhibitors,PKC
R12429 T16347 T16348 arg1Of inhibitors,and
R12430 T16348 T16344 arg2Of and,using
R12431 T16352 T16348 arg2Of constructs,and
R12432 T16352 T16349 arg1Of constructs,dominant
R12433 T16352 T16350 arg1Of constructs,negative
R12434 T16352 T16351 arg1Of constructs,PKCα
R12435 T16354 T16355 arg1Of PKCα,was
R12436 T16354 T16356 arg1Of PKCα,critical
R12437 T16354 T16362 arg1Of PKCα,inducing
R12438 T16355 T16341 arg1Of was,In
R12439 T16355 T16353 arg1Of was,","
R12440 T16355 T16357 arg1Of was,in
R12441 T16355 T16361 arg1Of was,by
R12442 T16356 T16355 arg2Of critical,was
R12443 T16360 T16357 arg2Of survival,in
R12444 T16360 T16358 arg1Of survival,M-CSF-induced
R12445 T16360 T16359 arg1Of survival,macrophage
R12446 T16362 T16361 arg2Of inducing,by
R12447 T16362 T16368 arg1Of inducing,in
R12448 T16364 T16362 arg2Of phosphorylation,inducing
R12449 T16364 T16363 arg1Of phosphorylation,Ser276
R12450 T16364 T16365 arg1Of phosphorylation,of
R12451 T16367 T16365 arg2Of p65,of
R12452 T16367 T16366 arg1Of p65,NF-κB
R12453 T16372 T16370 arg1Of MDMs,primary
R12454 T16372 T16371 arg1Of MDMs,human
R12455 T16372 T16373 arg1Of MDMs,and
R12456 T16373 T16368 arg2Of and,in
R12457 T16373 T16369 arg1Of and,both
R12458 T16376 T16373 arg2Of cells,and
R12459 T16376 T16374 arg1Of cells,Raw
R12460 T16376 T16375 arg1Of cells,264.7
R12461 T16377 T16379 arg1Of We,demonstrated
R12462 T16379 T16378 arg1Of demonstrated,also
R12463 T16381 T16380 arg1Of inhibition,PKC
R12464 T16381 T16382 arg1Of inhibition,downregulated
R12465 T16382 T16379 arg2Of downregulated,demonstrated
R12466 T16383 T16382 arg2Of NF-κB-induction,downregulated
R12467 T16383 T16384 arg1Of NF-κB-induction,of
R12468 T16388 T16384 arg2Of BCL-xL,of
R12469 T16388 T16385 arg1Of BCL-xL,the
R12470 T16388 T16386 arg1Of BCL-xL,anti-apoptotic
R12471 T16388 T16387 arg1Of BCL-xL,gene
R12472 T16389 T16390 arg1Of Consistent,with
R12473 T16392 T16390 arg2Of finding,with
R12474 T16392 T16391 arg1Of finding,our
R12475 T16394 T16389 arg1Of others,Consistent
R12476 T16394 T16395 arg1Of others,reported
R12477 T16395 T16389 modOf reported,Consistent
R12478 T16395 T16393 arg1Of reported,","
R12479 T16396 T16397 arg1Of NF-κB,regulated
R12480 T16397 T16395 arg2Of regulated,reported
R12481 T16400 T16397 arg2Of expression,regulated
R12482 T16400 T16398 arg1Of expression,the
R12483 T16400 T16399 arg1Of expression,gene
R12484 T16400 T16401 arg1Of expression,of
R12485 T16400 T16405 arg1Of expression,including
R12486 T16404 T16401 arg2Of proteins,of
R12487 T16404 T16402 arg1Of proteins,many
R12488 T16404 T16403 arg1Of proteins,anti-apoptotic
R12489 T16409 T16406 arg1Of members,other
R12490 T16409 T16407 arg1Of members,BCL-2
R12491 T16409 T16408 arg1Of members,family
R12492 T16409 T16410 arg1Of members,and
R12493 T16410 T16405 arg2Of and,including
R12494 T16411 T16412 arg1Of inhibitor,of
R12495 T16413 T16412 arg2Of apoptosis,of
R12496 T16413 T16414 arg1Of apoptosis,(
R12497 T16415 T16414 arg2Of IAP,(
R12498 T16416 T16414 arg3Of ),(
R12499 T16417 T16410 arg2Of proteins,and
R12500 T16417 T16411 arg1Of proteins,inhibitor
R12501 T16417 T16418 arg1Of proteins,which
R12502 T16417 T16419 arg1Of proteins,are
R12503 T16420 T16419 arg2Of regulators,are
R12504 T16420 T16421 arg1Of regulators,of
R12505 T16422 T16423 arg1Of apoptosis,and
R12506 T16423 T16421 arg2Of and,of
R12507 T16423 T16425 arg1Of and,upstream
R12508 T16424 T16423 arg2Of function,and
R12509 T16425 T16426 arg1Of upstream,of
R12510 T16427 T16426 arg2Of caspases,of
R12511 T16427 T16428 arg1Of caspases,[
R12512 T16429 T16428 arg2Of 44,[
R12513 T16430 T16428 arg3Of ],[
R12514 T16431 T16432 arg1Of It,has
R12515 T16431 T16433 arg1Of It,been
R12516 T16431 T16434 arg2Of It,shown
R12517 T16434 T16432 arg2Of shown,has
R12518 T16434 T16433 arg2Of shown,been
R12519 T16436 T16437 arg1Of phosphorylation,of
R12520 T16436 T16439 arg1Of phosphorylation,at
R12521 T16436 T16441 arg1Of phosphorylation,prevents
R12522 T16436 T16448 arg1Of phosphorylation,promotes
R12523 T16438 T16437 arg2Of p65,of
R12524 T16440 T16439 arg2Of Ser276,at
R12525 T16441 T16447 arg1Of prevents,and
R12526 T16443 T16441 arg2Of degradation,prevents
R12527 T16443 T16442 arg1Of degradation,its
R12528 T16443 T16444 arg1Of degradation,by
R12529 T16446 T16444 arg2Of proteolysis,by
R12530 T16446 T16445 arg1Of proteolysis,ubiquitin-mediated
R12531 T16447 T16434 arg3Of and,shown
R12532 T16447 T16435 arg1Of and,that
R12533 T16448 T16447 arg2Of promotes,and
R12534 T16448 T16451 arg1Of promotes,in
R12535 T16448 T16454 arg1Of promotes,[
R12536 T16450 T16448 arg2Of survival,promotes
R12537 T16450 T16449 arg1Of survival,cell
R12538 T16453 T16451 arg2Of cells,in
R12539 T16453 T16452 arg1Of cells,HeLa
R12540 T16455 T16454 arg2Of 24,[
R12541 T16456 T16454 arg3Of ],[
R12542 T16458 T16457 arg2Of addition,In
R12543 T16458 T16459 arg1Of addition,to
R12544 T16461 T16459 arg2Of expression,to
R12545 T16461 T16460 arg1Of expression,BCL-xL
R12546 T16461 T16462 arg1Of expression,as
R12547 T16463 T16462 arg2Of examined,as
R12548 T16463 T16464 arg1Of examined,in
R12549 T16466 T16464 arg2Of study,in
R12550 T16466 T16465 arg1Of study,this
R12551 T16468 T16469 arg1Of we,are
R12552 T16468 T16470 arg1Of we,evaluating
R12553 T16470 T16457 arg1Of evaluating,In
R12554 T16470 T16467 arg1Of evaluating,","
R12555 T16470 T16469 arg2Of evaluating,are
R12556 T16472 T16470 arg2Of possibility,evaluating
R12557 T16472 T16471 arg1Of possibility,the
R12558 T16476 T16474 arg1Of activity,PKCα-regulated
R12559 T16476 T16475 arg1Of activity,NF-κB
R12560 T16476 T16477 arg1Of activity,upregulates
R12561 T16477 T16472 arg2Of upregulates,possibility
R12562 T16477 T16473 arg1Of upregulates,that
R12563 T16477 T16481 arg1Of upregulates,in
R12564 T16477 T16485 modOf upregulates,to
R12565 T16480 T16477 arg2Of genes,upregulates
R12566 T16480 T16478 arg1Of genes,additional
R12567 T16480 T16479 arg1Of genes,anti-apoptotic
R12568 T16484 T16481 arg2Of fashion,in
R12569 T16484 T16482 arg1Of fashion,an
R12570 T16484 T16483 arg1Of fashion,M-CSF-dependent
R12571 T16486 T16485 arg1Of modulate,to
R12572 T16488 T16486 arg2Of survival,modulate
R12573 T16488 T16487 arg1Of survival,cell
R12574 T16490 T16489 arg1Of use,The
R12575 T16490 T16491 arg1Of use,of
R12576 T16490 T16495 arg1Of use,in
R12577 T16490 T16498 arg1Of use,has
R12578 T16490 T16500 arg1Of use,ruled
R12579 T16492 T16493 arg1Of inhibitors,and
R12580 T16493 T16491 arg2Of and,of
R12581 T16494 T16493 arg2Of siRNA,and
R12582 T16497 T16495 arg2Of study,in
R12583 T16497 T16496 arg1Of study,our
R12584 T16500 T16498 arg2Of ruled,has
R12585 T16500 T16499 arg1Of ruled,not
R12586 T16500 T16501 arg1Of ruled,out
R12587 T16505 T16503 arg1Of PKCs,other
R12588 T16505 T16504 arg1Of PKCs,conventional
R12589 T16505 T16506 arg1Of PKCs,might
R12590 T16505 T16508 arg1Of PKCs,be
R12591 T16505 T16509 arg1Of PKCs,important
R12592 T16508 T16500 arg2Of be,ruled
R12593 T16508 T16502 arg1Of be,that
R12594 T16508 T16506 arg2Of be,might
R12595 T16508 T16507 arg1Of be,also
R12596 T16508 T16510 arg1Of be,in
R12597 T16509 T16508 arg2Of important,be
R12598 T16513 T16511 arg1Of activation,M-CSF-induced
R12599 T16513 T16512 arg1Of activation,NF-κB
R12600 T16513 T16514 arg1Of activation,and
R12601 T16514 T16510 arg2Of and,in
R12602 T16516 T16514 arg2Of survival,and
R12603 T16516 T16515 arg1Of survival,macrophage
R12604 T16517 T16519 arg1Of In,to
R12605 T16518 T16517 arg2Of contrast,In
R12606 T16521 T16520 arg1Of actions,the
R12607 T16521 T16522 arg1Of actions,of
R12608 T16521 T16534 arg1Of actions,appear
R12609 T16521 T16535 arg1Of actions,necessary
R12610 T16524 T16522 arg2Of activation,of
R12611 T16524 T16523 arg1Of activation,PKCα
R12612 T16524 T16525 arg1Of activation,of
R12613 T16529 T16525 arg2Of isoforms,of
R12614 T16529 T16526 arg1Of isoforms,other
R12615 T16529 T16527 arg1Of isoforms,conventional
R12616 T16529 T16528 arg1Of isoforms,PKC
R12617 T16532 T16531 arg2Of PKCβI/βII,like
R12618 T16534 T16517 arg1Of appear,In
R12619 T16534 T16530 arg1Of appear,","
R12620 T16534 T16531 arg1Of appear,like
R12621 T16534 T16533 arg1Of appear,","
R12622 T16535 T16534 arg2Of necessary,appear
R12623 T16535 T16536 arg1Of necessary,for
R12624 T16538 T16536 arg2Of apoptosis,for
R12625 T16538 T16537 arg1Of apoptosis,macrophage
R12626 T16541 T16539 arg1Of isoforms,The
R12627 T16541 T16540 arg1Of isoforms,PKCβI/βII
R12628 T16541 T16542 arg1Of isoforms,are
R12629 T16541 T16543 arg2Of isoforms,expressed
R12630 T16543 T16542 arg2Of expressed,are
R12631 T16543 T16544 arg1Of expressed,in
R12632 T16543 T16549 arg1Of expressed,[
R12633 T16548 T16544 arg2Of cells,in
R12634 T16548 T16545 arg1Of cells,apoptotic
R12635 T16548 T16546 arg1Of cells,U937
R12636 T16548 T16547 arg1Of cells,myelomonocytic
R12637 T16550 T16549 arg2Of 45,[
R12638 T16551 T16549 arg3Of ],[
R12639 T16557 T16552 arg1Of HL-525,The
R12640 T16557 T16553 arg1Of HL-525,human
R12641 T16557 T16554 arg1Of HL-525,myeloid
R12642 T16557 T16555 arg1Of HL-525,cell
R12643 T16557 T16556 arg1Of HL-525,line
R12644 T16557 T16558 arg1Of HL-525,which
R12645 T16557 T16559 arg1Of HL-525,is
R12646 T16557 T16560 arg1Of HL-525,devoid
R12647 T16557 T16564 arg1Of HL-525,is
R12648 T16557 T16565 arg1Of HL-525,resistant
R12649 T16560 T16559 arg2Of devoid,is
R12650 T16560 T16561 arg1Of devoid,of
R12651 T16563 T16561 arg2Of PKCβII,of
R12652 T16563 T16562 arg1Of PKCβII,endogenous
R12653 T16565 T16564 arg2Of resistant,is
R12654 T16565 T16566 arg1Of resistant,to
R12655 T16568 T16566 arg2Of apoptosis,to
R12656 T16568 T16567 arg1Of apoptosis,TNFα-induced
R12657 T16568 T16569 arg1Of apoptosis,[
R12658 T16570 T16569 arg2Of 46,[
R12659 T16571 T16569 arg3Of ],[
R12660 T16572 T16573 arg1Of Re-expression,of
R12661 T16572 T16575 arg1Of Re-expression,in
R12662 T16572 T16578 arg1Of Re-expression,restores
R12663 T16572 T16590 arg1Of Re-expression,may
R12664 T16572 T16591 arg1Of Re-expression,be
R12665 T16572 T16592 arg2Of Re-expression,required
R12666 T16574 T16573 arg2Of PKCβII,of
R12667 T16577 T16575 arg2Of cells,in
R12668 T16577 T16576 arg1Of cells,HL-525
R12669 T16578 T16589 arg1Of restores,and
R12670 T16580 T16578 arg2Of susceptibility,restores
R12671 T16580 T16579 arg1Of susceptibility,their
R12672 T16580 T16581 arg1Of susceptibility,to
R12673 T16583 T16581 arg2Of apoptosis,to
R12674 T16583 T16582 arg1Of apoptosis,TNFα-induced
R12675 T16583 T16584 arg1Of apoptosis,implying
R12676 T16586 T16587 arg1Of PKCβII,is
R12677 T16586 T16588 arg1Of PKCβII,pro-apoptotic
R12678 T16587 T16584 arg2Of is,implying
R12679 T16587 T16585 arg1Of is,that
R12680 T16588 T16587 arg2Of pro-apoptotic,is
R12681 T16592 T16589 arg2Of required,and
R12682 T16592 T16590 arg2Of required,may
R12683 T16592 T16591 arg2Of required,be
R12684 T16592 T16593 modOf required,to
R12685 T16594 T16593 arg1Of induce,to
R12686 T16596 T16594 arg2Of apoptosis,induce
R12687 T16596 T16595 arg1Of apoptosis,macrophage
R12688 T16598 T16597 arg1Of studies,Recent
R12689 T16598 T16599 arg1Of studies,demonstrated
R12690 T16603 T16601 arg1Of activity,NF-κB
R12691 T16603 T16602 arg1Of activity,transcriptional
R12692 T16603 T16604 arg1Of activity,can
R12693 T16603 T16605 arg1Of activity,be
R12694 T16603 T16606 arg2Of activity,regulated
R12695 T16606 T16599 arg2Of regulated,demonstrated
R12696 T16606 T16600 arg1Of regulated,that
R12697 T16606 T16604 arg2Of regulated,can
R12698 T16606 T16605 arg2Of regulated,be
R12699 T16606 T16620 arg1Of regulated,[
R12700 T16608 T16606 arg1Of phosphorylation,regulated
R12701 T16608 T16607 arg2Of phosphorylation,by
R12702 T16608 T16609 arg1Of phosphorylation,of
R12703 T16608 T16614 arg1Of phosphorylation,in
R12704 T16613 T16609 arg2Of subunit,of
R12705 T16613 T16610 arg1Of subunit,the
R12706 T16613 T16611 arg1Of subunit,NF-κB
R12707 T16613 T16612 arg1Of subunit,p65
R12708 T16616 T16614 arg2Of absence,in
R12709 T16616 T16615 arg1Of absence,the
R12710 T16616 T16617 arg1Of absence,of
R12711 T16619 T16617 arg2Of degradation,of
R12712 T16619 T16618 arg1Of degradation,IκBα
R12713 T16621 T16620 arg2Of 47,[
R12714 T16622 T16620 arg3Of ],[
R12715 T16625 T16623 arg2Of pathway,By
R12716 T16625 T16624 arg1Of pathway,this
R12717 T16627 T16628 arg1Of phosphorylation,of
R12718 T16627 T16630 arg1Of phosphorylation,regulates
R12719 T16627 T16642 arg1Of phosphorylation,affecting
R12720 T16629 T16628 arg2Of NF-κB,of
R12721 T16630 T16623 arg1Of regulates,By
R12722 T16630 T16626 arg1Of regulates,","
R12723 T16630 T16641 arg1Of regulates,without
R12724 T16632 T16630 arg2Of interaction,regulates
R12725 T16632 T16631 arg1Of interaction,its
R12726 T16632 T16633 arg1Of interaction,with
R12727 T16635 T16633 arg2Of components,with
R12728 T16635 T16634 arg1Of components,other
R12729 T16635 T16636 arg1Of components,of
R12730 T16640 T16636 arg2Of machinery,of
R12731 T16640 T16637 arg1Of machinery,the
R12732 T16640 T16638 arg1Of machinery,basal
R12733 T16640 T16639 arg1Of machinery,transcriptional
R12734 T16642 T16641 arg2Of affecting,without
R12735 T16740 T16736 arg1Of and,formed
R12736 T16740 T16737 arg2Of and,by
R12737 T16743 T16740 arg2Of co-activators,and
R12738 T16743 T16741 arg1Of co-activators,other
R12739 T16743 T16742 arg1Of co-activators,transcriptional
R12740 T16745 T16744 arg2Of response,in
R12741 T16745 T16746 arg1Of response,to
R12742 T16747 T16748 arg1Of M-CSF,and
R12743 T16749 T16748 arg2Of PKC,and
R12744 T16750 T16746 arg2Of activation,to
R12745 T16750 T16747 arg1Of activation,M-CSF
R12746 T16750 T16749 arg1Of activation,PKC
R12747 T16752 T16753 arg1Of studies,indicated
R12748 T16753 T16751 arg1Of indicated,Recently
R12749 T16644 T16642 arg2Of capability,affecting
R12750 T16644 T16643 arg1Of capability,its
R12751 T16644 T16645 modOf capability,to
R12752 T16757 T16755 arg1Of pathway,the
R12753 T16646 T16645 arg1Of bind,to
R12754 T16646 T16648 arg1Of bind,[
R12755 T16647 T16646 arg2Of DNA,bind
R12756 T16649 T16648 arg2Of 21,[
R12757 T16650 T16648 arg3Of ],[
R12758 T16757 T16756 arg1Of pathway,non-canonical
R12759 T16757 T16758 arg1Of pathway,was
R12760 T16652 T16653 arg1Of NF-κB,can
R12761 T16652 T16654 arg1Of NF-κB,bind
R12762 T16757 T16759 arg2Of pathway,activated
R12763 T16654 T16651 arg2Of bind,Since
R12764 T16654 T16653 arg2Of bind,can
R12765 T16759 T16753 arg2Of activated,indicated
R12766 T16656 T16654 arg2Of promoters,bind
R12767 T16656 T16655 arg1Of promoters,the
R12768 T16656 T16657 arg1Of promoters,of
R12769 T16759 T16754 arg1Of activated,that
R12770 T16660 T16657 arg2Of targets,of
R12771 T16660 T16658 arg1Of targets,numerous
R12772 T16660 T16659 arg1Of targets,gene
R12773 T16759 T16758 arg2Of activated,was
R12774 T16759 T16760 arg1Of activated,during
R12775 T16663 T16662 arg1Of modification,post-translational
R12776 T16663 T16664 arg1Of modification,of
R12777 T16663 T16667 arg1Of modification,may
R12778 T16663 T16668 arg1Of modification,affect
R12779 T16663 T16675 arg1Of modification,refining
R12780 T16666 T16664 arg2Of p65,of
R12781 T16666 T16665 arg1Of p65,NF-κB
R12782 T16763 T16760 arg2Of differentiation,during
R12783 T16668 T16651 arg1Of affect,Since
R12784 T16668 T16661 arg1Of affect,","
R12785 T16668 T16667 arg2Of affect,may
R12786 T16668 T16674 arg1Of affect,","
R12787 T16670 T16668 arg2Of interaction,affect
R12788 T16670 T16669 arg1Of interaction,its
R12789 T16670 T16671 arg1Of interaction,with
R12790 T16673 T16671 arg2Of proteins,with
R12791 T16673 T16672 arg1Of proteins,other
R12792 T16675 T16668 arg3Of refining,affect
R12793 T16763 T16761 arg1Of differentiation,human
R12794 T16677 T16675 arg2Of expression,refining
R12795 T16677 T16676 arg1Of expression,the
R12796 T16677 T16678 arg1Of expression,of
R12797 T16763 T16762 arg1Of differentiation,monocyte-macrophage
R12798 T16763 T16764 arg1Of differentiation,[
R12799 T16680 T16678 arg2Of targets,of
R12800 T16680 T16679 arg1Of targets,gene
R12801 T16681 T16682 arg1Of We,did
R12802 T16681 T16684 arg1Of We,find
R12803 T16765 T16764 arg2Of 48,[
R12804 T16684 T16682 arg2Of find,did
R12805 T16684 T16683 arg1Of find,not
R12806 T16766 T16764 arg3Of ],[
R12807 T16686 T16687 arg1Of PKC,was
R12808 T16769 T16767 arg2Of process,During
R12809 T16686 T16688 arg2Of PKC,involved
R12810 T16688 T16685 arg1Of involved,that
R12811 T16688 T16687 arg2Of involved,was
R12812 T16688 T16689 arg1Of involved,in
R12813 T16688 T16701 arg1Of involved,but
R12814 T16769 T16768 arg1Of process,this
R12815 T16771 T16772 arg1Of expression,of
R12816 T16691 T16690 arg1Of degradation,IκBα
R12817 T16691 T16692 arg1Of degradation,or
R12818 T16692 T16689 arg2Of or,in
R12819 T16692 T16697 arg2Of or,induced
R12820 T16771 T16774 arg1Of expression,among
R12821 T16771 T16778 arg1Of expression,is
R12822 T16696 T16692 arg2Of translocation,or
R12823 T16696 T16693 arg1Of translocation,NF-κB
R12824 T16696 T16694 arg1Of translocation,p65
R12825 T16696 T16695 arg1Of translocation,nuclear
R12826 T16699 T16697 arg1Of M-CSF,induced
R12827 T16699 T16698 arg2Of M-CSF,by
R12828 T16771 T16779 arg2Of expression,elevated
R12829 T16701 T16684 arg2Of but,find
R12830 T16701 T16700 arg1Of but,","
R12831 T16773 T16772 arg2Of IKKα,of
R12832 T16702 T16701 arg2Of that,but
R12833 T16704 T16703 arg1Of phosphorylation,M-CSF-induced
R12834 T16704 T16705 arg1Of phosphorylation,of
R12835 T16704 T16710 arg1Of phosphorylation,was
R12836 T16704 T16712 arg2Of phosphorylation,reduced
R12837 T16776 T16774 arg2Of proteins,among
R12838 T16707 T16705 arg2Of p65,of
R12839 T16707 T16706 arg1Of p65,NF-κB
R12840 T16707 T16708 arg1Of p65,at
R12841 T16709 T16708 arg2Of Ser276,at
R12842 T16712 T16702 arg2Of reduced,that
R12843 T16712 T16710 arg2Of reduced,was
R12844 T16712 T16711 arg1Of reduced,dramatically
R12845 T16712 T16713 arg1Of reduced,by
R12846 T16712 T16723 arg1Of reduced,by
R12847 T16713 T16722 arg1Of by,and
R12848 T16776 T16775 arg1Of proteins,other
R12849 T16779 T16767 arg1Of elevated,During
R12850 T16717 T16715 arg1Of inhibitor,conventional
R12851 T16717 T16716 arg1Of inhibitor,PKC
R12852 T16779 T16770 arg1Of elevated,","
R12853 T16717 T16718 arg1Of inhibitor,and
R12854 T16779 T16777 arg1Of elevated,","
R12855 T16779 T16778 arg2Of elevated,is
R12856 T16718 T16713 arg2Of and,by
R12857 T16718 T16714 arg1Of and,the
R12858 T16779 T16780 modOf elevated,leading
R12859 T16779 T16789 arg1Of elevated,through
R12860 T16780 T16781 arg1Of leading,to
R12861 T16721 T16718 arg2Of PKCα,and
R12862 T16721 T16719 arg1Of PKCα,kinase
R12863 T16721 T16720 arg1Of PKCα,deficient
R12864 T16723 T16722 arg2Of by,and
R12865 T16724 T16723 arg2Of siRNA,by
R12866 T16724 T16725 arg1Of siRNA,towards
R12867 T16784 T16781 arg2Of NF-κB,to
R12868 T16726 T16725 arg2Of PKCα,towards
R12869 T16728 T16727 arg1Of studies,Current
R12870 T16728 T16729 arg1Of studies,are
R12871 T16728 T16730 arg1Of studies,underway
R12872 T16728 T16732 arg1Of studies,delineate
R12873 T16730 T16729 arg2Of underway,are
R12874 T16732 T16730 arg2Of delineate,underway
R12875 T16732 T16731 arg1Of delineate,to
R12876 T16732 T16744 arg1Of delineate,in
R12877 T16735 T16732 arg2Of complexes,delineate
R12878 T16735 T16733 arg1Of complexes,the
R12879 T16735 T16734 arg1Of complexes,protein
R12880 T16735 T16736 arg2Of complexes,formed
R12881 T16784 T16782 arg2Of NF-κB,increased
R12882 T16784 T16783 arg1Of NF-κB,p52
R12883 T16786 T16785 arg2Of relB,(
R12884 T16739 T16738 arg2Of NF-κB,activated
R12885 T16739 T16740 arg1Of NF-κB,and
R12886 T16787 T16785 arg3Of ),(
R12887 T16788 T16780 arg2Of expression,leading
R12888 T16788 T16785 arg1Of expression,(
R12889 T16792 T16789 arg2Of degradation,through
R12890 T16838 T16836 arg2Of apoptosis,prevented
R12891 T16838 T16837 arg1Of apoptosis,monocyte
R12892 T16840 T16839 arg2Of 3,[
R12893 T16792 T16790 arg1Of degradation,partial
R12894 T16841 T16839 arg3Of ],[
R12895 T16792 T16791 arg1Of degradation,proteolytic
R12896 T16843 T16842 arg1Of study,This
R12897 T16843 T16844 arg1Of study,reveals
R12898 T16792 T16793 arg1Of degradation,of
R12899 T16797 T16793 arg2Of protein,of
R12900 T16846 T16847 arg1Of treatment,of
R12901 T16846 T16854 arg1Of treatment,or
R12902 T16848 T16847 arg2Of monocytes,of
R12903 T16848 T16849 arg1Of monocytes,with
R12904 T16852 T16849 arg2Of inhibitors,with
R12905 T16852 T16850 arg1Of inhibitors,conventional
R12906 T16852 T16851 arg1Of inhibitors,PKC
R12907 T16854 T16853 arg1Of or,","
R12908 T16854 T16859 arg1Of or,blocked
R12909 T16797 T16794 arg1Of protein,the
R12910 T16855 T16854 arg2Of overexpression,or
R12911 T16855 T16856 arg1Of overexpression,of
R12912 T16797 T16795 arg1Of protein,p100
R12913 T16797 T16796 arg1Of protein,NF-κB
R12914 T16858 T16856 arg2Of PKCα,of
R12915 T16858 T16857 arg1Of PKCα,kinase-deficient
R12916 T16801 T16798 arg1Of is,Thus
R12917 T16859 T16844 arg2Of blocked,reveals
R12918 T16859 T16845 arg1Of blocked,that
R12919 T16862 T16859 arg2Of survival,blocked
R12920 T16862 T16860 arg1Of survival,M-CSF-induced
R12921 T16862 T16861 arg1Of survival,cell
R12922 T16864 T16863 arg1Of data,Our
R12923 T16864 T16865 arg1Of data,revealed
R12924 T16801 T16799 arg1Of is,","
R12925 T16802 T16801 arg2Of possible,is
R12926 T16868 T16867 arg1Of PKCs,conventional
R12927 T16868 T16869 arg1Of PKCs,are
R12928 T16868 T16871 arg1Of PKCs,of
R12929 T16868 T16879 arg1Of PKCs,mediate
R12930 T16868 T16886 arg1Of PKCs,phosphorylating
R12931 T16868 T16889 arg1Of PKCs,regulate
R12932 T16869 T16870 arg1Of are,upstream
R12933 T16869 T16874 arg1Of are,in
R12934 T16869 T16878 arg1Of are,and
R12935 T16871 T16869 arg2Of of,are
R12936 T16873 T16871 arg2Of activation,of
R12937 T16873 T16872 arg1Of activation,NF-κB
R12938 T16874 T16876 arg1Of in,to
R12939 T16875 T16874 arg2Of response,in
R12940 T16804 T16805 arg1Of M-CSF,regulates
R12941 T16877 T16874 arg3Of M-CSF,in
R12942 T16878 T16865 arg2Of and,revealed
R12943 T16878 T16866 arg1Of and,that
R12944 T16879 T16878 arg2Of mediate,and
R12945 T16879 T16885 arg1Of mediate,by
R12946 T16805 T16800 arg1Of regulates,it
R12947 T16881 T16879 arg2Of activation,mediate
R12948 T16881 T16880 arg1Of activation,post-translational
R12949 T16881 T16882 arg1Of activation,of
R12950 T16805 T16801 arg1Of regulates,is
R12951 T16884 T16882 arg2Of p65,of
R12952 T16884 T16883 arg1Of p65,NF-κB
R12953 T16805 T16802 arg1Of regulates,possible
R12954 T16886 T16885 arg2Of phosphorylating,by
R12955 T16886 T16888 modOf phosphorylating,to
R12956 T16805 T16803 arg1Of regulates,that
R12957 T16887 T16886 arg2Of Ser276,phosphorylating
R12958 T16805 T16808 arg1Of regulates,through
R12959 T16889 T16888 arg1Of regulate,to
R12960 T16807 T16805 arg2Of survival,regulates
R12961 T16891 T16890 arg1Of transcription,gene
R12962 T16891 T16892 arg1Of transcription,and
R12963 T16892 T16889 arg2Of and,regulate
R12964 T16807 T16806 arg1Of survival,monocyte
R12965 T16894 T16892 arg2Of survival,and
R12966 T16894 T16893 arg1Of survival,cell
R12967 T16811 T16812 arg1Of canonical,and
R12968 T16898 T16897 arg1Of observation,our
R12969 T16898 T16899 arg1Of observation,may
R12970 T16898 T16900 arg1Of observation,provide
R12971 T16900 T16895 arg1Of provide,Thus
R12972 T16900 T16896 arg1Of provide,","
R12973 T16900 T16899 arg2Of provide,may
R12974 T16900 T16902 arg1Of provide,in
R12975 T16813 T16812 arg2Of non-canonical,and
R12976 T16815 T16808 arg2Of pathways,through
R12977 T16901 T16900 arg2Of insight,provide
R12978 T16905 T16902 arg2Of targets,in
R12979 T16905 T16903 arg1Of targets,potential
R12980 T16815 T16809 arg1Of pathways,both
R12981 T16815 T16810 arg1Of pathways,the
R12982 T16905 T16904 arg1Of targets,therapeutic
R12983 T16905 T16906 arg1Of targets,for
R12984 T16815 T16811 arg1Of pathways,canonical
R12985 T16815 T16813 arg1Of pathways,non-canonical
R12986 T16815 T16814 arg1Of pathways,NF-κB
R12987 T16908 T16906 arg2Of diseases,for
R12988 T16908 T16907 arg1Of diseases,inflammatory
R12989 T16815 T16816 arg1Of pathways,","
R12990 T16815 T16817 arg1Of pathways,which
R12991 T16815 T16818 arg1Of pathways,will
R12992 T16815 T16819 arg1Of pathways,be
R12993 T16819 T16818 arg2Of be,will
R12994 T16821 T16819 arg2Of focus,be
R12995 T16821 T16820 arg1Of focus,a
R12996 T16821 T16822 arg1Of focus,in
R12997 T16824 T16822 arg2Of research,in
R13000 T16824 T16823 arg1Of research,future
R13001 T16825 T16827 arg1Of We,showed
R13002 T16827 T16826 arg1Of showed,previously
R13003 T16829 T16830 arg1Of M-CSF,reduced
R13004 T16829 T16836 arg1Of M-CSF,prevented
R13005 T16830 T16835 arg1Of reduced,and
R13006 T16831 T16832 arg1Of caspase-3,and
R13007 T16832 T16830 arg2Of and,reduced
R13008 T16834 T16832 arg2Of activity,and
R13009 T16834 T16833 arg1Of activity,-9
R13010 T16835 T16827 arg2Of and,showed
R13011 T16835 T16828 arg1Of and,that
R13012 T16836 T16835 arg2Of prevented,and
R13013 T16836 T16839 arg1Of prevented,[
R20493 T26866 T26865 arg2Of model,Proposed
R20494 T26866 T26867 arg1Of model,for
R20495 T26866 T26871 arg1Of model,via
R20496 T26866 T26874 arg1Of model,by
R20497 T26870 T26867 arg2Of survival,for
R20498 T26870 T26868 arg1Of survival,M-CSF-induced
R20499 T26870 T26869 arg1Of survival,monocyte
R20500 T26873 T26871 arg2Of regulation,via
R20501 T26873 T26872 arg1Of regulation,PKC
R20502 T26875 T26874 arg2Of activating,by
R20503 T26875 T26879 arg1Of activating,at
R20504 T26878 T26875 arg2Of phosphorylation,activating
R20505 T26878 T26876 arg1Of phosphorylation,NF-κB
R20506 T26878 T26877 arg1Of phosphorylation,p65
R20507 T26880 T26879 arg2Of Ser276,at

sentences

Id Subject Object Predicate Lexical cue
T14475 174-358 Sentence denotes To regulate gene transcription, NF-κB p50/p65 heterodimers translocate to the nucleus from the cytoplasm, however, their translocation is not sufficient to activate gene transcription.
T14476 359-518 Sentence denotes Post-translational modification of NF-κB heterodimers such as phosphorylation or acetylation also contributes to its transcriptional activity [41], [42], [43].
T14477 519-816 Sentence denotes Because NF-κB constitutively translocates to the nucleus in monocytic lineage [13] and activates gene transcription and survival in murine macrophages [11], we sought to determine how M-CSF affected NF-κB transcriptional activity in human MDMs and whether this activation regulated their survival.
T14478 817-967 Sentence denotes The present study demonstrated that M-CSF stimulated PKCα kinase upstream of NF-κB transcriptional activity in primary human MDMs and RAW 264.7 cells.
T14479 968-1137 Sentence denotes We showed inhibition of conventional PKCs by PKC inhibitors, kinase deficient PKCα or PKCα siRNA blocked M-CSF-induced cell survival and NF-κB-regulated gene expression.
T14480 1138-1233 Sentence denotes This block correlated with a reduction in M-CSF-induced phosphorylation of NF-κB p65 at Ser276.
T14481 1234-1457 Sentence denotes Consistent with these findings the dominant negative PKCα constructs also inhibited NF-κB p65 phosphorylation at Ser276 but not at Ser536 resulting in reduced NF-κB transcriptional activation and M-CSF-induced MDM survival.
T14482 1458-1628 Sentence denotes A simplified proposed cartoon model in Figure 9 demonstrates that M-CSF induced monocytes survival is regulated by activating NF-κB p65 phosphorylation at Ser276 via PKC.
T14483 1629-1792 Sentence denotes Finally, in a NF-κB p65−/− fibroblast cell line, we confirmed that the Ser276 residue of NF-κB p65 is important and essential for PKC modulation of NF-κB activity.
T14484 1793-1899 Sentence denotes More compelling is that we observed a similar regulation between two different cell lineages in our study.
T14485 2067-2178 Sentence denotes Post-translational modification of NF-κB p65 regulates its activating or repressing effects on gene expression.
T14486 2179-2335 Sentence denotes Among the seven reported putative NF-κB p65 phosphorylation sites, five increase nuclear translocation, DNA binding and NF-κB transcriptional activity [17].
T14487 2336-2508 Sentence denotes Similar to our finding, Zhong et al. found that in response to LPS, NF-κB p65 is phosphorylated at the highly conserved Ser276 residue by the catalytic subunit of PKA [16].
T14488 2509-2606 Sentence denotes In addition to PKA, Ser276 can be phosphorylated by MSK1 in the nucleus upon TNFα treatment [18].
T14489 2607-2763 Sentence denotes Phosphorylation of NF-κB p65 at Ser536 occurs in response to many inflammatory stimuli as well as kinases, IKKα, IKKβ and RSK1 [17], [18], [19], [20], [21].
T14490 2764-3024 Sentence denotes Notably, in addition to phosphorylating Ser276 of NF-κB, our study revealed that M-CSF also modulated the phosphorylation of the NF-κB p65 subunit at Ser536, however, PKC inhibitors or kinase deficient PKCα constructs did not affect this phosphorylation event.
T14491 3025-3251 Sentence denotes Moreover, mutant constructs containing a point mutation at Ser536 of NF-κB p65 did not reduce NF-κB activity in cells lacking endogenous NF-κB p65, while the NF-κB p65 276S/A construct did reduce NF-κB activity in these cells.
T14492 3252-3409 Sentence denotes Therefore, specific post-translational modification of NF-κB p65 is likely to regulate transcriptional activation in response to specific stimuli [15], [43].
T14493 3410-3536 Sentence denotes It is notable that M-CSF activated NF-κB p65 Ser276 phosphorylation and transcriptional activation in a PKCα-dependent manner.
T14494 3537-3670 Sentence denotes PKCα is a member of the conventional PKC family of protein kinases that are critical for cell growth, differentiation and cell death.
T14495 3671-3793 Sentence denotes PKCα primarily modulates anti-apoptotic and proliferation signals following cytokine treatment in various cell types [42].
T14496 3794-3923 Sentence denotes Expression of PKCα attenuates apoptosis in many different cell types, while PKCα inhibition generally potentiates apoptosis [42].
T14497 3924-4162 Sentence denotes In our studies using conventional PKC inhibitors and dominant negative PKCα constructs, PKCα was critical in M-CSF-induced macrophage survival by inducing Ser276 phosphorylation of NF-κB p65 in both primary human MDMs and Raw 264.7 cells.
T14498 4163-4263 Sentence denotes We also demonstrated PKC inhibition downregulated NF-κB-induction of the anti-apoptotic gene BCL-xL.
T14499 4264-4529 Sentence denotes Consistent with our finding, others reported NF-κB regulated the gene expression of many anti-apoptotic proteins including other BCL-2 family members and inhibitor of apoptosis (IAP) proteins which are regulators of apoptosis and function upstream of caspases [44].
T14500 4530-4691 Sentence denotes It has been shown that phosphorylation of p65 at Ser276 prevents its degradation by ubiquitin-mediated proteolysis and promotes cell survival in HeLa cells [24].
T14501 4692-4921 Sentence denotes In addition to BCL-xL expression as examined in this study, we are evaluating the possibility that PKCα-regulated NF-κB activity upregulates additional anti-apoptotic genes in an M-CSF-dependent fashion to modulate cell survival.
T14502 4922-5096 Sentence denotes The use of inhibitors and siRNA in our study has not ruled out that other conventional PKCs might also be important in M-CSF-induced NF-κB activation and macrophage survival.
T14503 5097-5237 Sentence denotes In contrast to the actions of PKCα activation of other conventional PKC isoforms, like PKCβI/βII, appear necessary for macrophage apoptosis.
T14504 5238-5319 Sentence denotes The PKCβI/βII isoforms are expressed in apoptotic U937 myelomonocytic cells [45].
T14505 5320-5436 Sentence denotes The human myeloid cell line HL-525 which is devoid of endogenous PKCβII is resistant to TNFα-induced apoptosis [46].
T14506 5437-5622 Sentence denotes Re-expression of PKCβII in HL-525 cells restores their susceptibility to TNFα-induced apoptosis implying that PKCβII is pro-apoptotic and may be required to induce macrophage apoptosis.
T14507 5623-5788 Sentence denotes Recent studies demonstrated that NF-κB transcriptional activity can be regulated by phosphorylation of the NF-κB p65 subunit in the absence of IκBα degradation [47].
T14508 5789-5968 Sentence denotes By this pathway, phosphorylation of NF-κB regulates its interaction with other components of the basal transcriptional machinery without affecting its capability to bind DNA [21].
T14509 5969-6163 Sentence denotes Since NF-κB can bind the promoters of numerous gene targets, post-translational modification of NF-κB p65 may affect its interaction with other proteins, refining the expression of gene targets.
T14510 6164-6448 Sentence denotes We did not find that PKC was involved in IκBα degradation or NF-κB p65 nuclear translocation induced by M-CSF, but that M-CSF-induced phosphorylation of NF-κB p65 at Ser276 was dramatically reduced by the conventional PKC inhibitor and kinase deficient PKCα and by siRNA towards PKCα.
T14511 6449-6619 Sentence denotes Current studies are underway to delineate the protein complexes formed by activated NF-κB and other transcriptional co-activators in response to M-CSF and PKC activation.
T14512 6620-6746 Sentence denotes Recently studies indicated that the non-canonical pathway was activated during human monocyte-macrophage differentiation [48].
T14513 6747-6936 Sentence denotes During this process, expression of IKKα among other proteins, is elevated leading to increased p52 NF-κB (relB) expression through partial proteolytic degradation of the p100 NF-κB protein.
T14514 6937-7099 Sentence denotes Thus, it is possible that M-CSF regulates monocyte survival through both the canonical and non-canonical NF-κB pathways, which will be a focus in future research.
T14515 7100-7203 Sentence denotes We previously showed that M-CSF reduced caspase-3 and -9 activity and prevented monocyte apoptosis [3].
T14516 7204-7364 Sentence denotes This study reveals that treatment of monocytes with conventional PKC inhibitors, or overexpression of kinase-deficient PKCα blocked M-CSF-induced cell survival.
T14517 7365-7590 Sentence denotes Our data revealed that conventional PKCs are upstream of NF-κB activation in response to M-CSF and mediate post-translational activation of NF-κB p65 by phosphorylating Ser276 to regulate gene transcription and cell survival.
T14518 7591-7692 Sentence denotes Thus, our observation may provide insight in potential therapeutic targets for inflammatory diseases.
T26847 1944-2064 Sentence denotes Proposed model for M-CSF-induced monocyte survival via PKC regulation by activating NF-κB p65 phosphorylation at Ser276.
T225 0-10 Sentence denotes Discussion
T226 11-173 Sentence denotes NF-κB transcriptional activity is important in regulating intracellular signaling, stress response, proliferation, survival, differentiation and inflammation [8].
T227 174-358 Sentence denotes To regulate gene transcription, NF-κB p50/p65 heterodimers translocate to the nucleus from the cytoplasm, however, their translocation is not sufficient to activate gene transcription.
T228 359-518 Sentence denotes Post-translational modification of NF-κB heterodimers such as phosphorylation or acetylation also contributes to its transcriptional activity [41], [42], [43].
T229 519-816 Sentence denotes Because NF-κB constitutively translocates to the nucleus in monocytic lineage [13] and activates gene transcription and survival in murine macrophages [11], we sought to determine how M-CSF affected NF-κB transcriptional activity in human MDMs and whether this activation regulated their survival.
T230 817-967 Sentence denotes The present study demonstrated that M-CSF stimulated PKCα kinase upstream of NF-κB transcriptional activity in primary human MDMs and RAW 264.7 cells.
T231 968-1137 Sentence denotes We showed inhibition of conventional PKCs by PKC inhibitors, kinase deficient PKCα or PKCα siRNA blocked M-CSF-induced cell survival and NF-κB-regulated gene expression.
T232 1138-1233 Sentence denotes This block correlated with a reduction in M-CSF-induced phosphorylation of NF-κB p65 at Ser276.
T233 1234-1457 Sentence denotes Consistent with these findings the dominant negative PKCα constructs also inhibited NF-κB p65 phosphorylation at Ser276 but not at Ser536 resulting in reduced NF-κB transcriptional activation and M-CSF-induced MDM survival.
T234 1458-1628 Sentence denotes A simplified proposed cartoon model in Figure 9 demonstrates that M-CSF induced monocytes survival is regulated by activating NF-κB p65 phosphorylation at Ser276 via PKC.
T235 1629-1792 Sentence denotes Finally, in a NF-κB p65−/− fibroblast cell line, we confirmed that the Ser276 residue of NF-κB p65 is important and essential for PKC modulation of NF-κB activity.
T236 1793-1899 Sentence denotes More compelling is that we observed a similar regulation between two different cell lineages in our study.
T237 1900-2064 Sentence denotes 10.1371/journal.pone.0028081.g009 Figure 9 Proposed model for M-CSF-induced monocyte survival via PKC regulation by activating NF-κB p65 phosphorylation at Ser276.
T238 2067-2178 Sentence denotes Post-translational modification of NF-κB p65 regulates its activating or repressing effects on gene expression.
T239 2179-2335 Sentence denotes Among the seven reported putative NF-κB p65 phosphorylation sites, five increase nuclear translocation, DNA binding and NF-κB transcriptional activity [17].
T240 2336-2508 Sentence denotes Similar to our finding, Zhong et al. found that in response to LPS, NF-κB p65 is phosphorylated at the highly conserved Ser276 residue by the catalytic subunit of PKA [16].
T241 2509-2606 Sentence denotes In addition to PKA, Ser276 can be phosphorylated by MSK1 in the nucleus upon TNFα treatment [18].
T242 2607-2763 Sentence denotes Phosphorylation of NF-κB p65 at Ser536 occurs in response to many inflammatory stimuli as well as kinases, IKKα, IKKβ and RSK1 [17], [18], [19], [20], [21].
T243 2764-3024 Sentence denotes Notably, in addition to phosphorylating Ser276 of NF-κB, our study revealed that M-CSF also modulated the phosphorylation of the NF-κB p65 subunit at Ser536, however, PKC inhibitors or kinase deficient PKCα constructs did not affect this phosphorylation event.
T244 3025-3251 Sentence denotes Moreover, mutant constructs containing a point mutation at Ser536 of NF-κB p65 did not reduce NF-κB activity in cells lacking endogenous NF-κB p65, while the NF-κB p65 276S/A construct did reduce NF-κB activity in these cells.
T245 3252-3409 Sentence denotes Therefore, specific post-translational modification of NF-κB p65 is likely to regulate transcriptional activation in response to specific stimuli [15], [43].
T246 3410-3536 Sentence denotes It is notable that M-CSF activated NF-κB p65 Ser276 phosphorylation and transcriptional activation in a PKCα-dependent manner.
T247 3537-3670 Sentence denotes PKCα is a member of the conventional PKC family of protein kinases that are critical for cell growth, differentiation and cell death.
T248 3671-3793 Sentence denotes PKCα primarily modulates anti-apoptotic and proliferation signals following cytokine treatment in various cell types [42].
T249 3794-3923 Sentence denotes Expression of PKCα attenuates apoptosis in many different cell types, while PKCα inhibition generally potentiates apoptosis [42].
T250 3924-4162 Sentence denotes In our studies using conventional PKC inhibitors and dominant negative PKCα constructs, PKCα was critical in M-CSF-induced macrophage survival by inducing Ser276 phosphorylation of NF-κB p65 in both primary human MDMs and Raw 264.7 cells.
T251 4163-4263 Sentence denotes We also demonstrated PKC inhibition downregulated NF-κB-induction of the anti-apoptotic gene BCL-xL.
T252 4264-4529 Sentence denotes Consistent with our finding, others reported NF-κB regulated the gene expression of many anti-apoptotic proteins including other BCL-2 family members and inhibitor of apoptosis (IAP) proteins which are regulators of apoptosis and function upstream of caspases [44].
T253 4530-4691 Sentence denotes It has been shown that phosphorylation of p65 at Ser276 prevents its degradation by ubiquitin-mediated proteolysis and promotes cell survival in HeLa cells [24].
T254 4692-4921 Sentence denotes In addition to BCL-xL expression as examined in this study, we are evaluating the possibility that PKCα-regulated NF-κB activity upregulates additional anti-apoptotic genes in an M-CSF-dependent fashion to modulate cell survival.
T255 4922-5096 Sentence denotes The use of inhibitors and siRNA in our study has not ruled out that other conventional PKCs might also be important in M-CSF-induced NF-κB activation and macrophage survival.
T256 5097-5237 Sentence denotes In contrast to the actions of PKCα activation of other conventional PKC isoforms, like PKCβI/βII, appear necessary for macrophage apoptosis.
T257 5238-5319 Sentence denotes The PKCβI/βII isoforms are expressed in apoptotic U937 myelomonocytic cells [45].
T258 5320-5436 Sentence denotes The human myeloid cell line HL-525 which is devoid of endogenous PKCβII is resistant to TNFα-induced apoptosis [46].
T259 5437-5622 Sentence denotes Re-expression of PKCβII in HL-525 cells restores their susceptibility to TNFα-induced apoptosis implying that PKCβII is pro-apoptotic and may be required to induce macrophage apoptosis.
T260 5623-5788 Sentence denotes Recent studies demonstrated that NF-κB transcriptional activity can be regulated by phosphorylation of the NF-κB p65 subunit in the absence of IκBα degradation [47].
T261 5789-5968 Sentence denotes By this pathway, phosphorylation of NF-κB regulates its interaction with other components of the basal transcriptional machinery without affecting its capability to bind DNA [21].
T262 5969-6163 Sentence denotes Since NF-κB can bind the promoters of numerous gene targets, post-translational modification of NF-κB p65 may affect its interaction with other proteins, refining the expression of gene targets.
T263 6164-6448 Sentence denotes We did not find that PKC was involved in IκBα degradation or NF-κB p65 nuclear translocation induced by M-CSF, but that M-CSF-induced phosphorylation of NF-κB p65 at Ser276 was dramatically reduced by the conventional PKC inhibitor and kinase deficient PKCα and by siRNA towards PKCα.
T264 6449-6619 Sentence denotes Current studies are underway to delineate the protein complexes formed by activated NF-κB and other transcriptional co-activators in response to M-CSF and PKC activation.
T265 6620-6746 Sentence denotes Recently studies indicated that the non-canonical pathway was activated during human monocyte-macrophage differentiation [48].
T266 6747-6936 Sentence denotes During this process, expression of IKKα among other proteins, is elevated leading to increased p52 NF-κB (relB) expression through partial proteolytic degradation of the p100 NF-κB protein.
T267 6937-7099 Sentence denotes Thus, it is possible that M-CSF regulates monocyte survival through both the canonical and non-canonical NF-κB pathways, which will be a focus in future research.
T268 7100-7203 Sentence denotes We previously showed that M-CSF reduced caspase-3 and -9 activity and prevented monocyte apoptosis [3].
T269 7204-7364 Sentence denotes This study reveals that treatment of monocytes with conventional PKC inhibitors, or overexpression of kinase-deficient PKCα blocked M-CSF-induced cell survival.
T270 7365-7590 Sentence denotes Our data revealed that conventional PKCs are upstream of NF-κB activation in response to M-CSF and mediate post-translational activation of NF-κB p65 by phosphorylating Ser276 to regulate gene transcription and cell survival.
T271 7591-7692 Sentence denotes Thus, our observation may provide insight in potential therapeutic targets for inflammatory diseases.

2_test

Id Subject Object Predicate Lexical cue
22216091-12464174-90609716 170-171 12464174 denotes 8
22216091-8875974-90609717 502-504 8875974 denotes 41
22216091-11781840-90609718 508-510 11781840 denotes 42
22216091-16410803-90609719 514-516 16410803 denotes 43
22216091-7998962-90609720 598-600 7998962 denotes 13
22216091-11073986-90609721 671-673 11073986 denotes 11
22216091-15122352-90609722 2331-2333 15122352 denotes 17
22216091-9150141-90609723 2504-2506 9150141 denotes 16
22216091-12628924-90609724 2602-2604 12628924 denotes 18
22216091-15122352-90609725 2735-2737 15122352 denotes 17
22216091-12628924-90609726 2741-2743 12628924 denotes 18
22216091-17405917-90609727 2747-2749 17405917 denotes 19
22216091-16105840-90609728 2753-2755 16105840 denotes 20
22216091-11931769-90609729 2759-2761 11931769 denotes 21
22216091-17072321-90609730 3399-3401 17072321 denotes 15
22216091-16410803-90609731 3405-3407 16410803 denotes 43
22216091-11781840-90609732 3789-3791 11781840 denotes 42
22216091-11781840-90609733 3919-3921 11781840 denotes 42
22216091-16187493-90609734 4525-4527 16187493 denotes 44
22216091-19911008-90609735 4687-4689 19911008 denotes 24
22216091-7796879-90609736 5315-5317 7796879 denotes 45
22216091-10438532-90609737 5432-5434 10438532 denotes 46
22216091-18267068-90609738 5784-5786 18267068 denotes 47
22216091-11931769-90609739 5964-5966 11931769 denotes 21
22216091-20711193-90609740 6742-6744 20711193 denotes 48
22216091-10473597-90609741 7200-7201 10473597 denotes 3

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T14525 58-68 VBG denotes regulating
T14526 69-82 JJ denotes intracellular
T14527 83-92 VBG denotes signaling
T14528 92-93 , denotes ,
T14529 94-100 NN denotes stress
T14530 101-109 NN denotes response
T14531 109-110 , denotes ,
T14532 111-124 NN denotes proliferation
T14533 124-125 , denotes ,
T14534 126-134 NN denotes survival
T14535 134-135 , denotes ,
T14536 136-151 NN denotes differentiation
T14537 152-155 CC denotes and
T14538 156-168 NN denotes inflammation
T14539 169-170 NN denotes [
T14540 170-171 CD denotes 8
T14541 171-172 NNP denotes ]
T14542 172-173 . denotes .
T14543 174-176 TO denotes To
T14544 177-185 VB denotes regulate
T14545 186-190 NN denotes gene
T14546 191-204 NN denotes transcription
T14547 204-205 , denotes ,
T14548 206-211 NNP denotes NF-κB
T14549 212-219 CD denotes p50/p65
T14550 220-232 NNS denotes heterodimers
T14551 233-244 VBP denotes translocate
T14552 245-247 TO denotes to
T14553 248-251 DT denotes the
T14554 252-259 NN denotes nucleus
T14555 260-264 IN denotes from
T14556 265-268 DT denotes the
T14557 269-278 NN denotes cytoplasm
T14558 278-279 , denotes ,
T14559 280-287 RB denotes however
T14560 287-288 , denotes ,
T14561 289-294 PRP$ denotes their
T14562 295-308 NN denotes translocation
T14563 309-311 VBZ denotes is
T14564 312-315 RB denotes not
T14565 316-326 JJ denotes sufficient
T14566 327-329 TO denotes to
T14567 330-338 VB denotes activate
T14568 339-343 NN denotes gene
T14569 344-357 NN denotes transcription
T14570 357-358 . denotes .
T14571 359-377 JJ denotes Post-translational
T14572 378-390 NN denotes modification
T14573 391-393 IN denotes of
T14574 394-399 JJ denotes NF-κB
T14575 400-412 NNS denotes heterodimers
T14576 413-417 JJ denotes such
T14577 418-420 IN denotes as
T14578 421-436 NN denotes phosphorylation
T14579 437-439 CC denotes or
T14580 440-451 NN denotes acetylation
T14581 452-456 RB denotes also
T14582 457-468 VBZ denotes contributes
T14583 469-471 TO denotes to
T14584 472-475 PRP$ denotes its
T14585 476-491 JJ denotes transcriptional
T14586 492-500 NN denotes activity
T14587 501-502 NNP denotes [
T14588 502-504 CD denotes 41
T14589 504-505 NNP denotes ]
T14590 505-506 , denotes ,
T14591 507-508 NNP denotes [
T14592 508-510 CD denotes 42
T14593 510-511 NNP denotes ]
T14594 511-512 , denotes ,
T14595 513-514 NNP denotes [
T14596 514-516 CD denotes 43
T14597 516-517 NNP denotes ]
T14598 517-518 . denotes .
T14599 519-526 IN denotes Because
T14600 527-532 JJ denotes NF-κB
T14601 533-547 RB denotes constitutively
T14602 548-560 VBZ denotes translocates
T14603 561-563 TO denotes to
T14604 564-567 DT denotes the
T14605 568-575 NN denotes nucleus
T14606 576-578 IN denotes in
T14607 579-588 JJ denotes monocytic
T14608 589-596 NN denotes lineage
T14609 597-598 NNP denotes [
T14610 598-600 CD denotes 13
T14611 600-601 NNP denotes ]
T14612 602-605 CC denotes and
T14613 606-615 VBZ denotes activates
T14614 616-620 NN denotes gene
T14615 621-634 NN denotes transcription
T14616 635-638 CC denotes and
T14617 639-647 NN denotes survival
T14618 648-650 IN denotes in
T14619 651-657 JJ denotes murine
T14620 658-669 NNS denotes macrophages
T14621 670-671 NNP denotes [
T14622 671-673 CD denotes 11
T14623 673-674 NNP denotes ]
T14624 674-675 , denotes ,
T14625 676-678 PRP denotes we
T14626 679-685 VBD denotes sought
T14627 686-688 TO denotes to
T14628 689-698 VB denotes determine
T14629 699-702 WRB denotes how
T14630 703-708 JJ denotes M-CSF
T14631 709-717 JJ denotes affected
T14632 718-723 NN denotes NF-κB
T14633 724-739 JJ denotes transcriptional
T14634 740-748 NN denotes activity
T14635 749-751 IN denotes in
T14636 752-757 JJ denotes human
T14637 758-762 NNS denotes MDMs
T14638 763-766 CC denotes and
T14639 767-774 IN denotes whether
T14640 775-779 DT denotes this
T14641 780-790 NN denotes activation
T14642 791-800 VBN denotes regulated
T14643 801-806 PRP$ denotes their
T14644 807-815 NN denotes survival
T14645 815-816 . denotes .
T14646 817-820 DT denotes The
T14647 821-828 JJ denotes present
T14648 829-834 NN denotes study
T14649 835-847 VBD denotes demonstrated
T14650 848-852 IN denotes that
T14651 853-858 NNP denotes M-CSF
T14652 859-869 VBD denotes stimulated
T14653 870-874 NNP denotes PKCα
T14654 875-881 NN denotes kinase
T14655 882-890 RB denotes upstream
T14656 891-893 IN denotes of
T14657 894-899 JJ denotes NF-κB
T14658 900-915 JJ denotes transcriptional
T14659 916-924 NN denotes activity
T14660 925-927 IN denotes in
T14661 928-935 JJ denotes primary
T14662 936-941 JJ denotes human
T14663 942-946 NNS denotes MDMs
T14664 947-950 CC denotes and
T14665 951-954 NNP denotes RAW
T14666 955-960 CD denotes 264.7
T14667 961-966 NNS denotes cells
T14668 966-967 . denotes .
T14669 968-970 PRP denotes We
T14670 971-977 VBD denotes showed
T14671 978-988 NN denotes inhibition
T14672 989-991 IN denotes of
T14673 992-1004 JJ denotes conventional
T14674 1005-1009 NNS denotes PKCs
T14675 1010-1012 IN denotes by
T14676 1013-1016 NNP denotes PKC
T14677 1017-1027 NNS denotes inhibitors
T14678 1027-1028 , denotes ,
T14679 1029-1035 NN denotes kinase
T14680 1036-1045 NN denotes deficient
T14681 1046-1050 NNP denotes PKCα
T14682 1051-1053 CC denotes or
T14683 1054-1058 NNP denotes PKCα
T14684 1059-1064 NNP denotes siRNA
T14685 1065-1072 VBD denotes blocked
T14686 1073-1086 JJ denotes M-CSF-induced
T14687 1087-1091 NN denotes cell
T14688 1092-1100 NN denotes survival
T14689 1101-1104 CC denotes and
T14690 1105-1120 JJ denotes NF-κB-regulated
T14691 1121-1125 NN denotes gene
T14692 1126-1136 NN denotes expression
T14693 1136-1137 . denotes .
T14694 1138-1142 DT denotes This
T14695 1143-1148 NN denotes block
T14696 1149-1159 VBN denotes correlated
T14697 1160-1164 IN denotes with
T14698 1165-1166 DT denotes a
T14699 1167-1176 NN denotes reduction
T14700 1177-1179 IN denotes in
T14701 1180-1193 JJ denotes M-CSF-induced
T14702 1194-1209 NN denotes phosphorylation
T14703 1210-1212 IN denotes of
T14704 1213-1218 NNP denotes NF-κB
T14705 1219-1222 NNS denotes p65
T14706 1223-1225 IN denotes at
T14707 1226-1232 NNP denotes Ser276
T14708 1232-1233 . denotes .
T14709 1234-1244 JJ denotes Consistent
T14710 1245-1249 IN denotes with
T14711 1250-1255 DT denotes these
T14712 1256-1264 NNS denotes findings
T14713 1265-1268 DT denotes the
T14714 1269-1277 JJ denotes dominant
T14715 1278-1286 JJ denotes negative
T14716 1287-1291 NNP denotes PKCα
T14717 1292-1302 NNS denotes constructs
T14718 1303-1307 RB denotes also
T14719 1308-1317 VBD denotes inhibited
T14720 1318-1323 NNP denotes NF-κB
T14721 1324-1327 CD denotes p65
T14722 1328-1343 NN denotes phosphorylation
T14723 1344-1346 IN denotes at
T14724 1347-1353 NNP denotes Ser276
T14725 1354-1357 CC denotes but
T14726 1358-1361 RB denotes not
T14727 1362-1364 IN denotes at
T14728 1365-1371 CD denotes Ser536
T14729 1372-1381 VBG denotes resulting
T14730 1382-1384 IN denotes in
T14731 1385-1392 VBN denotes reduced
T14732 1393-1398 NNP denotes NF-κB
T14733 1399-1414 JJ denotes transcriptional
T14734 1415-1425 NN denotes activation
T14735 1426-1429 CC denotes and
T14736 1430-1443 JJ denotes M-CSF-induced
T14737 1444-1447 NNP denotes MDM
T14738 1448-1456 NN denotes survival
T14739 1456-1457 . denotes .
T14740 1458-1459 DT denotes A
T14741 1460-1470 VBN denotes simplified
T14742 1471-1479 VBN denotes proposed
T14743 1480-1487 NN denotes cartoon
T14744 1488-1493 NN denotes model
T14745 1494-1496 IN denotes in
T14746 1497-1503 NN denotes Figure
T14747 1504-1505 CD denotes 9
T14748 1506-1518 VBZ denotes demonstrates
T14749 1519-1523 IN denotes that
T14750 1524-1529 NNP denotes M-CSF
T14751 1530-1537 VBD denotes induced
T14752 1538-1547 NNS denotes monocytes
T14753 1548-1556 NN denotes survival
T14754 1557-1559 VBZ denotes is
T14755 1560-1569 VBN denotes regulated
T14756 1570-1572 IN denotes by
T14757 1573-1583 VBG denotes activating
T14758 1584-1589 NNP denotes NF-κB
T14759 1590-1593 CD denotes p65
T14760 1594-1609 NN denotes phosphorylation
T14761 1610-1612 IN denotes at
T14762 1613-1619 NNP denotes Ser276
T14763 1620-1623 IN denotes via
T14764 1624-1627 NNP denotes PKC
T14765 1627-1628 . denotes .
T14766 1629-1636 RB denotes Finally
T14767 1636-1637 , denotes ,
T14768 1638-1640 IN denotes in
T14769 1641-1642 DT denotes a
T14770 1643-1648 NNP denotes NF-κB
T14771 1649-1652 CD denotes p65
T14772 1652-1653 CD denotes −
T14773 1653-1654 NN denotes /
T14774 1654-1655 NN denotes −
T14775 1656-1666 NN denotes fibroblast
T14776 1667-1671 NN denotes cell
T14777 1672-1676 NN denotes line
T14778 1676-1677 , denotes ,
T14779 1678-1680 PRP denotes we
T14780 1681-1690 VBD denotes confirmed
T14781 1691-1695 IN denotes that
T14782 1696-1699 DT denotes the
T14783 1700-1706 NNP denotes Ser276
T14784 1707-1714 NN denotes residue
T14785 1715-1717 IN denotes of
T14786 1718-1723 NNP denotes NF-κB
T14787 1724-1727 CD denotes p65
T14788 1728-1730 VBZ denotes is
T14789 1731-1740 JJ denotes important
T14790 1741-1744 CC denotes and
T14791 1745-1754 JJ denotes essential
T14792 1755-1758 IN denotes for
T14793 1759-1762 NNP denotes PKC
T14794 1763-1773 NN denotes modulation
T14795 1774-1776 IN denotes of
T14796 1777-1782 JJ denotes NF-κB
T14797 1783-1791 NN denotes activity
T14798 1791-1792 . denotes .
T14799 1793-1797 RBR denotes More
T14800 1798-1808 JJ denotes compelling
T14801 1809-1811 VBZ denotes is
T14802 1812-1816 IN denotes that
T14803 1817-1819 PRP denotes we
T14804 1820-1828 VBD denotes observed
T14805 1829-1830 DT denotes a
T14806 1831-1838 JJ denotes similar
T14807 1839-1849 NN denotes regulation
T14808 1850-1857 IN denotes between
T14809 1858-1861 CD denotes two
T14810 1862-1871 JJ denotes different
T14811 1872-1876 NN denotes cell
T14812 1877-1885 NNS denotes lineages
T14813 1886-1888 IN denotes in
T14814 1889-1892 PRP$ denotes our
T14815 1893-1898 NN denotes study
T14816 1898-1899 . denotes .
T14817 2067-2085 JJ denotes Post-translational
T14818 2086-2098 NN denotes modification
T14819 2099-2101 IN denotes of
T14820 2102-2107 NNP denotes NF-κB
T14821 2108-2111 CD denotes p65
T14822 2112-2121 VBZ denotes regulates
T14823 2122-2125 PRP$ denotes its
T14824 2126-2136 NN denotes activating
T14825 2137-2139 CC denotes or
T14826 2140-2150 VBG denotes repressing
T14827 2151-2158 NNS denotes effects
T14828 2159-2161 IN denotes on
T14829 2162-2166 NN denotes gene
T14830 2167-2177 NN denotes expression
T14831 2177-2178 . denotes .
T14832 2179-2184 IN denotes Among
T14833 2185-2188 DT denotes the
T14834 2189-2194 CD denotes seven
T14835 2195-2203 VBD denotes reported
T14836 2204-2212 JJ denotes putative
T14837 2213-2218 NNP denotes NF-κB
T14838 2219-2222 CD denotes p65
T14839 2223-2238 NN denotes phosphorylation
T14840 2239-2244 NNS denotes sites
T14841 2244-2245 , denotes ,
T14842 2246-2250 CD denotes five
T14843 2251-2259 NN denotes increase
T14844 2260-2267 JJ denotes nuclear
T14845 2268-2281 NN denotes translocation
T14846 2281-2282 , denotes ,
T14847 2283-2286 NNP denotes DNA
T14848 2287-2294 JJ denotes binding
T14849 2295-2298 CC denotes and
T14850 2299-2304 JJ denotes NF-κB
T14851 2305-2320 JJ denotes transcriptional
T14852 2321-2329 NN denotes activity
T14853 2330-2331 NNP denotes [
T14854 2331-2333 CD denotes 17
T14855 2333-2334 NNP denotes ]
T14856 2334-2335 . denotes .
T14857 2336-2343 JJ denotes Similar
T14858 2344-2346 TO denotes to
T14859 2347-2350 PRP$ denotes our
T14860 2351-2358 NN denotes finding
T14861 2358-2359 , denotes ,
T14862 2360-2365 NNP denotes Zhong
T14863 2366-2368 FW denotes et
T14864 2369-2372 FW denotes al.
T14865 2373-2378 VBD denotes found
T14866 2379-2383 IN denotes that
T14867 2384-2386 IN denotes in
T14868 2387-2395 NN denotes response
T14869 2396-2398 TO denotes to
T14870 2399-2402 NNP denotes LPS
T14871 2402-2403 , denotes ,
T14872 2404-2409 NNP denotes NF-κB
T14873 2410-2413 CD denotes p65
T14874 2414-2416 VBZ denotes is
T14875 2417-2431 VBN denotes phosphorylated
T14876 2432-2434 IN denotes at
T14877 2435-2438 DT denotes the
T14878 2439-2445 RB denotes highly
T14879 2446-2455 VBN denotes conserved
T14880 2456-2462 NNP denotes Ser276
T14881 2463-2470 NN denotes residue
T14882 2471-2473 IN denotes by
T14883 2474-2477 DT denotes the
T14884 2478-2487 JJ denotes catalytic
T14885 2488-2495 NN denotes subunit
T14886 2496-2498 IN denotes of
T14887 2499-2502 NNP denotes PKA
T14888 2503-2504 NNP denotes [
T14889 2504-2506 CD denotes 16
T14890 2506-2507 NNP denotes ]
T14891 2507-2508 . denotes .
T14892 2509-2511 IN denotes In
T14893 2512-2520 NN denotes addition
T14894 2521-2523 TO denotes to
T14895 2524-2527 NNP denotes PKA
T14896 2527-2528 , denotes ,
T14897 2529-2535 NNP denotes Ser276
T14898 2536-2539 MD denotes can
T14899 2540-2542 VB denotes be
T14900 2543-2557 VBN denotes phosphorylated
T14901 2558-2560 IN denotes by
T14902 2561-2565 NNP denotes MSK1
T14903 2566-2568 IN denotes in
T14904 2569-2572 DT denotes the
T14905 2573-2580 NN denotes nucleus
T14906 2581-2585 IN denotes upon
T14907 2586-2590 NNP denotes TNFα
T14908 2591-2600 NN denotes treatment
T14909 2601-2602 NNP denotes [
T14910 2602-2604 CD denotes 18
T14911 2604-2605 NNP denotes ]
T14912 2605-2606 . denotes .
T14913 2607-2622 NNP denotes Phosphorylation
T14914 2623-2625 IN denotes of
T14915 2626-2631 NNP denotes NF-κB
T14916 2632-2635 NNS denotes p65
T14917 2636-2638 IN denotes at
T14918 2639-2645 NNP denotes Ser536
T14919 2646-2652 VBZ denotes occurs
T14920 2653-2655 IN denotes in
T14921 2656-2664 NN denotes response
T14922 2665-2667 TO denotes to
T14923 2668-2672 JJ denotes many
T14924 2673-2685 JJ denotes inflammatory
T14925 2686-2693 NNS denotes stimuli
T14926 2694-2696 RB denotes as
T14927 2697-2701 RB denotes well
T14928 2702-2704 IN denotes as
T14929 2705-2712 NNS denotes kinases
T14930 2712-2713 , denotes ,
T14931 2714-2718 NNP denotes IKKα
T14932 2718-2719 , denotes ,
T14933 2720-2724 NNP denotes IKKβ
T14934 2725-2728 CC denotes and
T14935 2729-2733 NNP denotes RSK1
T14936 2734-2735 NNP denotes [
T14937 2735-2737 CD denotes 17
T14938 2737-2738 NNP denotes ]
T14939 2738-2739 , denotes ,
T14940 2740-2741 NNP denotes [
T14941 2741-2743 CD denotes 18
T14942 2743-2744 NNP denotes ]
T14943 2744-2745 , denotes ,
T14944 2746-2747 NNP denotes [
T14945 2747-2749 CD denotes 19
T14946 2749-2750 NNP denotes ]
T14947 2750-2751 , denotes ,
T14948 2752-2753 NNP denotes [
T14949 2753-2755 CD denotes 20
T14950 2755-2756 NNP denotes ]
T14951 2756-2757 , denotes ,
T14952 2758-2759 NNP denotes [
T14953 2759-2761 CD denotes 21
T14954 2761-2762 NNP denotes ]
T14955 2762-2763 . denotes .
T14956 2764-2771 RB denotes Notably
T14957 2771-2772 , denotes ,
T14958 2773-2775 IN denotes in
T14959 2776-2784 NN denotes addition
T14960 2785-2787 TO denotes to
T14961 2788-2803 VBG denotes phosphorylating
T14962 2804-2810 NNP denotes Ser276
T14963 2811-2813 IN denotes of
T14964 2814-2819 NNP denotes NF-κB
T14965 2819-2820 , denotes ,
T14966 2821-2824 PRP$ denotes our
T14967 2825-2830 NN denotes study
T14968 2831-2839 VBD denotes revealed
T14969 2840-2844 IN denotes that
T14970 2845-2850 NNP denotes M-CSF
T14971 2851-2855 RB denotes also
T14972 2856-2865 VBD denotes modulated
T14973 2866-2869 DT denotes the
T14974 2870-2885 NN denotes phosphorylation
T14975 2886-2888 IN denotes of
T14976 2889-2892 DT denotes the
T14977 2893-2898 NNP denotes NF-κB
T14978 2899-2902 CD denotes p65
T14979 2903-2910 NN denotes subunit
T14980 2911-2913 IN denotes at
T14981 2914-2920 NNP denotes Ser536
T14982 2920-2921 , denotes ,
T14983 2922-2929 RB denotes however
T14984 2929-2930 , denotes ,
T14985 2931-2934 NNP denotes PKC
T14986 2935-2945 NNS denotes inhibitors
T14987 2946-2948 CC denotes or
T14988 2949-2955 VB denotes kinase
T14989 2956-2965 JJ denotes deficient
T14990 2966-2970 NNP denotes PKCα
T14991 2971-2981 NNS denotes constructs
T14992 2982-2985 VBD denotes did
T14993 2986-2989 RB denotes not
T14994 2990-2996 VB denotes affect
T14995 2997-3001 DT denotes this
T14996 3002-3017 NN denotes phosphorylation
T14997 3018-3023 NN denotes event
T14998 3023-3024 . denotes .
T14999 3025-3033 RB denotes Moreover
T15000 3033-3034 , denotes ,
T15001 3035-3041 JJ denotes mutant
T15002 3042-3052 NNS denotes constructs
T15003 3053-3063 VBG denotes containing
T15004 3064-3065 DT denotes a
T15005 3066-3071 NN denotes point
T15006 3072-3080 NN denotes mutation
T15007 3081-3083 IN denotes at
T15008 3084-3090 NNP denotes Ser536
T15009 3091-3093 IN denotes of
T15010 3094-3099 NNP denotes NF-κB
T15011 3100-3103 CD denotes p65
T15012 3104-3107 VBD denotes did
T15013 3108-3111 RB denotes not
T15014 3112-3118 VB denotes reduce
T15015 3119-3124 JJ denotes NF-κB
T15016 3125-3133 NN denotes activity
T15017 3134-3136 IN denotes in
T15018 3137-3142 NNS denotes cells
T15019 3143-3150 VBG denotes lacking
T15020 3151-3161 JJ denotes endogenous
T15021 3162-3167 NNP denotes NF-κB
T15022 3168-3171 NNS denotes p65
T15023 3171-3172 , denotes ,
T15024 3173-3178 IN denotes while
T15025 3179-3182 DT denotes the
T15026 3183-3188 NNP denotes NF-κB
T15027 3189-3192 CD denotes p65
T15028 3193-3199 NNP denotes 276S/A
T15029 3200-3209 VB denotes construct
T15030 3210-3213 VBD denotes did
T15031 3214-3220 VB denotes reduce
T15032 3221-3226 NN denotes NF-κB
T15033 3227-3235 NN denotes activity
T15034 3236-3238 IN denotes in
T15035 3239-3244 DT denotes these
T15036 3245-3250 NNS denotes cells
T15037 3250-3251 . denotes .
T15038 3252-3261 RB denotes Therefore
T15039 3261-3262 , denotes ,
T15040 3263-3271 JJ denotes specific
T15041 3272-3290 JJ denotes post-translational
T15042 3291-3303 NN denotes modification
T15043 3304-3306 IN denotes of
T15044 3307-3312 NNP denotes NF-κB
T15045 3313-3316 CD denotes p65
T15046 3317-3319 VBZ denotes is
T15047 3320-3326 JJ denotes likely
T15048 3327-3329 TO denotes to
T15049 3330-3338 VB denotes regulate
T15050 3339-3354 JJ denotes transcriptional
T15051 3355-3365 NN denotes activation
T15052 3366-3368 IN denotes in
T15053 3369-3377 NN denotes response
T15054 3378-3380 TO denotes to
T15055 3381-3389 JJ denotes specific
T15056 3390-3397 NNS denotes stimuli
T15057 3398-3399 NNP denotes [
T15058 3399-3401 CD denotes 15
T15059 3401-3402 NNP denotes ]
T15060 3402-3403 , denotes ,
T15061 3404-3405 NNP denotes [
T15062 3405-3407 CD denotes 43
T15063 3407-3408 NNP denotes ]
T15064 3408-3409 . denotes .
T15065 3410-3412 PRP denotes It
T15066 3413-3415 VBZ denotes is
T15067 3416-3423 JJ denotes notable
T15068 3424-3428 IN denotes that
T15069 3429-3434 NNP denotes M-CSF
T15070 3435-3444 VBD denotes activated
T15071 3445-3450 NNP denotes NF-κB
T15072 3451-3454 CD denotes p65
T15073 3455-3461 NNP denotes Ser276
T15074 3462-3477 NN denotes phosphorylation
T15075 3478-3481 CC denotes and
T15076 3482-3497 JJ denotes transcriptional
T15077 3498-3508 NN denotes activation
T15078 3509-3511 IN denotes in
T15079 3512-3513 DT denotes a
T15080 3514-3528 JJ denotes PKCα-dependent
T15081 3529-3535 NN denotes manner
T15082 3535-3536 . denotes .
T15083 3537-3541 NNP denotes PKCα
T15084 3542-3544 VBZ denotes is
T15085 3545-3546 DT denotes a
T15086 3547-3553 NN denotes member
T15087 3554-3556 IN denotes of
T15088 3557-3560 DT denotes the
T15089 3561-3573 JJ denotes conventional
T15090 3574-3577 NNP denotes PKC
T15091 3578-3584 NN denotes family
T15092 3585-3587 IN denotes of
T15093 3588-3595 NN denotes protein
T15094 3596-3603 NNS denotes kinases
T15095 3604-3608 WDT denotes that
T15096 3609-3612 VBP denotes are
T15097 3613-3621 JJ denotes critical
T15098 3622-3625 IN denotes for
T15099 3626-3630 NN denotes cell
T15100 3631-3637 NN denotes growth
T15101 3637-3638 , denotes ,
T15102 3639-3654 NN denotes differentiation
T15103 3655-3658 CC denotes and
T15104 3659-3663 NN denotes cell
T15105 3664-3669 NN denotes death
T15106 3669-3670 . denotes .
T15107 3671-3675 NNP denotes PKCα
T15108 3676-3685 RB denotes primarily
T15109 3686-3695 VBZ denotes modulates
T15110 3696-3710 JJ denotes anti-apoptotic
T15111 3711-3714 CC denotes and
T15112 3715-3728 NN denotes proliferation
T15113 3729-3736 NNS denotes signals
T15114 3737-3746 VBG denotes following
T15115 3747-3755 JJ denotes cytokine
T15116 3756-3765 NN denotes treatment
T15117 3766-3768 IN denotes in
T15118 3769-3776 JJ denotes various
T15119 3777-3781 NN denotes cell
T15120 3782-3787 NNS denotes types
T15121 3788-3789 NNP denotes [
T15122 3789-3791 CD denotes 42
T15123 3791-3792 NNP denotes ]
T15124 3792-3793 . denotes .
T15125 3794-3804 NN denotes Expression
T15126 3805-3807 IN denotes of
T15127 3808-3812 NNP denotes PKCα
T15128 3813-3823 VBZ denotes attenuates
T15129 3824-3833 NN denotes apoptosis
T15130 3834-3836 IN denotes in
T15131 3837-3841 JJ denotes many
T15132 3842-3851 JJ denotes different
T15133 3852-3856 NN denotes cell
T15134 3857-3862 NNS denotes types
T15135 3862-3863 , denotes ,
T15136 3864-3869 IN denotes while
T15137 3870-3874 NNP denotes PKCα
T15138 3875-3885 NN denotes inhibition
T15139 3886-3895 RB denotes generally
T15140 3896-3907 VBZ denotes potentiates
T15141 3908-3917 NN denotes apoptosis
T15142 3918-3919 NNP denotes [
T15143 3919-3921 CD denotes 42
T15144 3921-3922 NNP denotes ]
T15145 3922-3923 . denotes .
T15146 3924-3926 IN denotes In
T15147 3927-3930 PRP$ denotes our
T15148 3931-3938 NNS denotes studies
T15149 3939-3944 VBG denotes using
T15150 3945-3957 JJ denotes conventional
T15151 3958-3961 NNP denotes PKC
T15152 3962-3972 NNS denotes inhibitors
T15153 3973-3976 CC denotes and
T15154 3977-3985 JJ denotes dominant
T15155 3986-3994 JJ denotes negative
T15156 3995-3999 NNP denotes PKCα
T15157 4000-4010 NNS denotes constructs
T15158 4010-4011 , denotes ,
T15159 4012-4016 NNP denotes PKCα
T15160 4017-4020 VBD denotes was
T15161 4021-4029 JJ denotes critical
T15162 4030-4032 IN denotes in
T15163 4033-4046 JJ denotes M-CSF-induced
T15164 4047-4057 NN denotes macrophage
T15165 4058-4066 NN denotes survival
T15166 4067-4069 IN denotes by
T15167 4070-4078 VBG denotes inducing
T15168 4079-4085 NNP denotes Ser276
T15169 4086-4101 NN denotes phosphorylation
T15170 4102-4104 IN denotes of
T15171 4105-4110 NNP denotes NF-κB
T15172 4111-4114 CD denotes p65
T15173 4115-4117 IN denotes in
T15174 4118-4122 DT denotes both
T15175 4123-4130 JJ denotes primary
T15176 4131-4136 JJ denotes human
T15177 4137-4141 NNS denotes MDMs
T15178 4142-4145 CC denotes and
T15179 4146-4149 NNP denotes Raw
T15180 4150-4155 CD denotes 264.7
T15181 4156-4161 NNS denotes cells
T15182 4161-4162 . denotes .
T15183 4163-4165 PRP denotes We
T15184 4166-4170 RB denotes also
T15185 4171-4183 VBD denotes demonstrated
T15186 4184-4187 NNP denotes PKC
T15187 4188-4198 NN denotes inhibition
T15188 4199-4212 VBD denotes downregulated
T15189 4213-4228 NNP denotes NF-κB-induction
T15190 4229-4231 IN denotes of
T15191 4232-4235 DT denotes the
T15192 4236-4250 JJ denotes anti-apoptotic
T15193 4251-4255 NN denotes gene
T15194 4256-4262 NN denotes BCL-xL
T15195 4262-4263 . denotes .
T15196 4264-4274 JJ denotes Consistent
T15197 4275-4279 IN denotes with
T15198 4280-4283 PRP$ denotes our
T15199 4284-4291 NN denotes finding
T15200 4291-4292 , denotes ,
T15201 4293-4299 NNS denotes others
T15202 4300-4308 VBD denotes reported
T15203 4309-4314 JJ denotes NF-κB
T15204 4315-4324 VBN denotes regulated
T15205 4325-4328 DT denotes the
T15206 4329-4333 NN denotes gene
T15207 4334-4344 NN denotes expression
T15208 4345-4347 IN denotes of
T15209 4348-4352 JJ denotes many
T15210 4353-4367 JJ denotes anti-apoptotic
T15211 4368-4376 NNS denotes proteins
T15212 4377-4386 VBG denotes including
T15213 4387-4392 JJ denotes other
T15214 4393-4398 NNP denotes BCL-2
T15215 4399-4405 NN denotes family
T15216 4406-4413 NNS denotes members
T15217 4414-4417 CC denotes and
T15218 4418-4427 NN denotes inhibitor
T15219 4428-4430 IN denotes of
T15220 4431-4440 NN denotes apoptosis
T15221 4441-4442 -LRB- denotes (
T15222 4442-4445 NNP denotes IAP
T15223 4445-4446 -RRB- denotes )
T15224 4447-4455 NNS denotes proteins
T15225 4456-4461 WDT denotes which
T15226 4462-4465 VBP denotes are
T15227 4466-4476 NNS denotes regulators
T15228 4477-4479 IN denotes of
T15229 4480-4489 NN denotes apoptosis
T15230 4490-4493 CC denotes and
T15231 4494-4502 NN denotes function
T15232 4503-4511 RB denotes upstream
T15233 4512-4514 IN denotes of
T15234 4515-4523 NNS denotes caspases
T15235 4524-4525 NNP denotes [
T15236 4525-4527 CD denotes 44
T15237 4527-4528 NNP denotes ]
T15238 4528-4529 . denotes .
T15239 4530-4532 PRP denotes It
T15240 4533-4536 VBZ denotes has
T15241 4537-4541 VBN denotes been
T15242 4542-4547 VBN denotes shown
T15243 4548-4552 IN denotes that
T15244 4553-4568 NN denotes phosphorylation
T15245 4569-4571 IN denotes of
T15246 4572-4575 NNS denotes p65
T15247 4576-4578 IN denotes at
T15248 4579-4585 NNP denotes Ser276
T15249 4586-4594 VBZ denotes prevents
T15250 4595-4598 PRP$ denotes its
T15251 4599-4610 NN denotes degradation
T15252 4611-4613 IN denotes by
T15253 4614-4632 JJ denotes ubiquitin-mediated
T15254 4633-4644 NN denotes proteolysis
T15255 4645-4648 CC denotes and
T15256 4649-4657 VBZ denotes promotes
T15257 4658-4662 NN denotes cell
T15258 4663-4671 NN denotes survival
T15259 4672-4674 IN denotes in
T15260 4675-4679 NNP denotes HeLa
T15261 4680-4685 NNS denotes cells
T15262 4686-4687 NNP denotes [
T15263 4687-4689 CD denotes 24
T15264 4689-4690 NNP denotes ]
T15265 4690-4691 . denotes .
T15266 4692-4694 IN denotes In
T15267 4695-4703 NN denotes addition
T15268 4704-4706 TO denotes to
T15269 4707-4713 JJ denotes BCL-xL
T15270 4714-4724 NN denotes expression
T15271 4725-4727 IN denotes as
T15272 4728-4736 VBN denotes examined
T15273 4737-4739 IN denotes in
T15274 4740-4744 DT denotes this
T15275 4745-4750 NN denotes study
T15276 4750-4751 , denotes ,
T15277 4752-4754 PRP denotes we
T15278 4755-4758 VBP denotes are
T15279 4759-4769 VBG denotes evaluating
T15280 4770-4773 DT denotes the
T15281 4774-4785 NN denotes possibility
T15282 4786-4790 IN denotes that
T15283 4791-4805 JJ denotes PKCα-regulated
T15284 4806-4811 NN denotes NF-κB
T15285 4812-4820 NN denotes activity
T15286 4821-4832 VBZ denotes upregulates
T15287 4833-4843 JJ denotes additional
T15288 4844-4858 JJ denotes anti-apoptotic
T15289 4859-4864 NNS denotes genes
T15290 4865-4867 IN denotes in
T15291 4868-4870 DT denotes an
T15292 4871-4886 JJ denotes M-CSF-dependent
T15293 4887-4894 NN denotes fashion
T15294 4895-4897 TO denotes to
T15295 4898-4906 VB denotes modulate
T15296 4907-4911 NN denotes cell
T15297 4912-4920 NN denotes survival
T15298 4920-4921 . denotes .
T15299 4922-4925 DT denotes The
T15300 4926-4929 NN denotes use
T15301 4930-4932 IN denotes of
T15302 4933-4943 NNS denotes inhibitors
T15303 4944-4947 CC denotes and
T15304 4948-4953 NN denotes siRNA
T15305 4954-4956 IN denotes in
T15306 4957-4960 PRP$ denotes our
T15307 4961-4966 NN denotes study
T15308 4967-4970 VBZ denotes has
T15309 4971-4974 RB denotes not
T15310 4975-4980 VBN denotes ruled
T15311 4981-4984 RP denotes out
T15312 4985-4989 IN denotes that
T15313 4990-4995 JJ denotes other
T15314 4996-5008 JJ denotes conventional
T15315 5009-5013 NNS denotes PKCs
T15316 5014-5019 MD denotes might
T15317 5020-5024 RB denotes also
T15318 5025-5027 VB denotes be
T15319 5028-5037 JJ denotes important
T15320 5038-5040 IN denotes in
T15321 5041-5054 JJ denotes M-CSF-induced
T15322 5055-5060 NN denotes NF-κB
T15323 5061-5071 NN denotes activation
T15324 5072-5075 CC denotes and
T15325 5076-5086 NN denotes macrophage
T15326 5087-5095 NN denotes survival
T15327 5095-5096 . denotes .
T15328 5097-5099 IN denotes In
T15329 5100-5108 NN denotes contrast
T15330 5109-5111 TO denotes to
T15331 5112-5115 DT denotes the
T15332 5116-5123 NNS denotes actions
T15333 5124-5126 IN denotes of
T15334 5127-5131 NNP denotes PKCα
T15335 5132-5142 NN denotes activation
T15336 5143-5145 IN denotes of
T15337 5146-5151 JJ denotes other
T15338 5152-5164 JJ denotes conventional
T15339 5165-5168 NNP denotes PKC
T15340 5169-5177 NNS denotes isoforms
T15341 5177-5178 , denotes ,
T15342 5179-5183 IN denotes like
T15343 5184-5189 NNP denotes PKCβI
T15344 5189-5190 NNP denotes /
T15345 5190-5193 NNP denotes βII
T15346 5193-5194 , denotes ,
T15347 5195-5201 VBP denotes appear
T15348 5202-5211 JJ denotes necessary
T15349 5212-5215 IN denotes for
T15350 5216-5226 NN denotes macrophage
T15351 5227-5236 NN denotes apoptosis
T15352 5236-5237 . denotes .
T15353 5238-5241 DT denotes The
T15354 5242-5247 NNP denotes PKCβI
T15355 5247-5248 NNP denotes /
T15356 5248-5251 NNP denotes βII
T15357 5252-5260 NNS denotes isoforms
T15358 5261-5264 VBP denotes are
T15359 5265-5274 VBN denotes expressed
T15360 5275-5277 IN denotes in
T15361 5278-5287 JJ denotes apoptotic
T15362 5288-5292 NNP denotes U937
T15363 5293-5307 JJ denotes myelomonocytic
T15364 5308-5313 NNS denotes cells
T15365 5314-5315 NNP denotes [
T15366 5315-5317 CD denotes 45
T15367 5317-5318 NNP denotes ]
T15368 5318-5319 . denotes .
T15369 5320-5323 DT denotes The
T15370 5324-5329 JJ denotes human
T15371 5330-5337 JJ denotes myeloid
T15372 5338-5342 NN denotes cell
T15373 5343-5347 NN denotes line
T15374 5348-5354 NN denotes HL-525
T15375 5355-5360 WDT denotes which
T15376 5361-5363 VBZ denotes is
T15377 5364-5370 JJ denotes devoid
T15378 5371-5373 IN denotes of
T15379 5374-5384 JJ denotes endogenous
T15380 5385-5391 NNP denotes PKCβII
T15381 5392-5394 VBZ denotes is
T15382 5395-5404 JJ denotes resistant
T15383 5405-5407 TO denotes to
T15384 5408-5420 JJ denotes TNFα-induced
T15385 5421-5430 NN denotes apoptosis
T15386 5431-5432 NNP denotes [
T15387 5432-5434 CD denotes 46
T15388 5434-5435 NNP denotes ]
T15389 5435-5436 . denotes .
T15390 5437-5450 NN denotes Re-expression
T15391 5451-5453 IN denotes of
T15392 5454-5460 NNP denotes PKCβII
T15393 5461-5463 IN denotes in
T15394 5464-5470 NNP denotes HL-525
T15395 5471-5476 NNS denotes cells
T15396 5477-5485 VBZ denotes restores
T15397 5486-5491 PRP$ denotes their
T15398 5492-5506 NN denotes susceptibility
T15399 5507-5509 TO denotes to
T15400 5510-5522 JJ denotes TNFα-induced
T15401 5523-5532 NN denotes apoptosis
T15402 5533-5541 VBG denotes implying
T15403 5542-5546 IN denotes that
T15404 5547-5553 NNP denotes PKCβII
T15405 5554-5556 VBZ denotes is
T15406 5557-5570 JJ denotes pro-apoptotic
T15407 5571-5574 CC denotes and
T15408 5575-5578 MD denotes may
T15409 5579-5581 VB denotes be
T15410 5582-5590 VBN denotes required
T15411 5591-5593 TO denotes to
T15412 5594-5600 VB denotes induce
T15413 5601-5611 NN denotes macrophage
T15414 5612-5621 NN denotes apoptosis
T15415 5621-5622 . denotes .
T15416 5623-5629 JJ denotes Recent
T15417 5630-5637 NNS denotes studies
T15418 5638-5650 VBD denotes demonstrated
T15419 5651-5655 IN denotes that
T15420 5656-5661 JJ denotes NF-κB
T15421 5662-5677 JJ denotes transcriptional
T15422 5678-5686 NN denotes activity
T15423 5687-5690 MD denotes can
T15424 5691-5693 VB denotes be
T15425 5694-5703 VBN denotes regulated
T15426 5704-5706 IN denotes by
T15427 5707-5722 NN denotes phosphorylation
T15428 5723-5725 IN denotes of
T15429 5726-5729 DT denotes the
T15430 5730-5735 NNP denotes NF-κB
T15431 5736-5739 CD denotes p65
T15432 5740-5747 NN denotes subunit
T15433 5748-5750 IN denotes in
T15434 5751-5754 DT denotes the
T15435 5755-5762 NN denotes absence
T15436 5763-5765 IN denotes of
T15437 5766-5770 NNP denotes IκBα
T15438 5771-5782 NN denotes degradation
T15439 5783-5784 NNP denotes [
T15440 5784-5786 CD denotes 47
T15441 5786-5787 NNP denotes ]
T15442 5787-5788 . denotes .
T15443 5789-5791 IN denotes By
T15444 5792-5796 DT denotes this
T15445 5797-5804 NN denotes pathway
T15446 5804-5805 , denotes ,
T15447 5806-5821 NN denotes phosphorylation
T15448 5822-5824 IN denotes of
T15449 5825-5830 JJ denotes NF-κB
T15450 5831-5840 VBZ denotes regulates
T15451 5841-5844 PRP$ denotes its
T15452 5845-5856 NN denotes interaction
T15453 5857-5861 IN denotes with
T15454 5862-5867 JJ denotes other
T15455 5868-5878 NNS denotes components
T15456 5879-5881 IN denotes of
T15457 5882-5885 DT denotes the
T15458 5886-5891 JJ denotes basal
T15459 5892-5907 JJ denotes transcriptional
T15460 5908-5917 NN denotes machinery
T15461 5918-5925 IN denotes without
T15462 5926-5935 VBG denotes affecting
T15463 5936-5939 PRP$ denotes its
T15464 5940-5950 NN denotes capability
T15465 5951-5953 TO denotes to
T15466 5954-5958 NN denotes bind
T15467 5959-5962 NNP denotes DNA
T15468 5963-5964 NNP denotes [
T15469 5964-5966 CD denotes 21
T15470 5966-5967 NNP denotes ]
T15471 5967-5968 . denotes .
T15472 5969-5974 IN denotes Since
T15473 5975-5980 NNP denotes NF-κB
T15474 5981-5984 MD denotes can
T15475 5985-5989 NN denotes bind
T15476 5990-5993 DT denotes the
T15477 5994-6003 NNS denotes promoters
T15478 6004-6006 IN denotes of
T15479 6007-6015 JJ denotes numerous
T15480 6016-6020 NN denotes gene
T15481 6021-6028 NNS denotes targets
T15482 6028-6029 , denotes ,
T15483 6030-6048 JJ denotes post-translational
T15484 6049-6061 NN denotes modification
T15485 6062-6064 IN denotes of
T15486 6065-6070 NNP denotes NF-κB
T15487 6071-6074 NNS denotes p65
T15488 6075-6078 MD denotes may
T15489 6079-6085 VB denotes affect
T15490 6086-6089 PRP$ denotes its
T15491 6090-6101 NN denotes interaction
T15492 6102-6106 IN denotes with
T15493 6107-6112 JJ denotes other
T15494 6113-6121 NNS denotes proteins
T15495 6121-6122 , denotes ,
T15496 6123-6131 VBG denotes refining
T15497 6132-6135 DT denotes the
T15498 6136-6146 NN denotes expression
T15499 6147-6149 IN denotes of
T15500 6150-6154 NN denotes gene
T15501 6155-6162 NNS denotes targets
T15502 6162-6163 . denotes .
T15503 6164-6166 PRP denotes We
T15504 6167-6170 VBD denotes did
T15505 6171-6174 RB denotes not
T15506 6175-6179 VB denotes find
T15507 6180-6184 DT denotes that
T15508 6185-6188 NNP denotes PKC
T15509 6189-6192 VBD denotes was
T15510 6193-6201 VBN denotes involved
T15511 6202-6204 IN denotes in
T15512 6205-6209 NNP denotes IκBα
T15513 6210-6221 NN denotes degradation
T15514 6222-6224 CC denotes or
T15515 6225-6230 NN denotes NF-κB
T15516 6231-6234 NNS denotes p65
T15517 6235-6242 JJ denotes nuclear
T15518 6243-6256 NN denotes translocation
T15519 6257-6264 VBN denotes induced
T15520 6265-6267 IN denotes by
T15521 6268-6273 NNP denotes M-CSF
T15522 6273-6274 , denotes ,
T15523 6275-6278 CC denotes but
T15524 6279-6283 DT denotes that
T15525 6284-6297 JJ denotes M-CSF-induced
T15526 6298-6313 NN denotes phosphorylation
T15527 6314-6316 IN denotes of
T15528 6317-6322 NNP denotes NF-κB
T15529 6323-6326 NNS denotes p65
T15530 6327-6329 IN denotes at
T15531 6330-6336 NNP denotes Ser276
T15532 6337-6340 VBD denotes was
T15533 6341-6353 RB denotes dramatically
T15534 6354-6361 VBN denotes reduced
T15535 6362-6364 IN denotes by
T15536 6365-6368 DT denotes the
T15537 6369-6381 JJ denotes conventional
T15538 6382-6385 NNP denotes PKC
T15539 6386-6395 NN denotes inhibitor
T15540 6396-6399 CC denotes and
T15541 6400-6406 NN denotes kinase
T15542 6407-6416 NN denotes deficient
T15543 6417-6421 NNP denotes PKCα
T15544 6422-6425 CC denotes and
T15545 6426-6428 IN denotes by
T15546 6429-6434 NNP denotes siRNA
T15547 6435-6442 IN denotes towards
T15548 6443-6447 NNP denotes PKCα
T15549 6447-6448 . denotes .
T15550 6449-6456 JJ denotes Current
T15551 6457-6464 NNS denotes studies
T15552 6465-6468 VBP denotes are
T15553 6469-6477 JJ denotes underway
T15554 6478-6480 TO denotes to
T15555 6481-6490 VB denotes delineate
T15556 6491-6494 DT denotes the
T15557 6495-6502 NN denotes protein
T15558 6503-6512 NNS denotes complexes
T15559 6513-6519 VBN denotes formed
T15560 6520-6522 IN denotes by
T15561 6523-6532 VBN denotes activated
T15562 6533-6538 NNP denotes NF-κB
T15563 6539-6542 CC denotes and
T15564 6543-6548 JJ denotes other
T15565 6549-6564 JJ denotes transcriptional
T15566 6565-6578 NNS denotes co-activators
T15567 6579-6581 IN denotes in
T15568 6582-6590 NN denotes response
T15569 6591-6593 TO denotes to
T15570 6594-6599 NNP denotes M-CSF
T15571 6600-6603 CC denotes and
T15572 6604-6607 NNP denotes PKC
T15573 6608-6618 NN denotes activation
T15574 6618-6619 . denotes .
T15575 6620-6628 RB denotes Recently
T15576 6629-6636 NNS denotes studies
T15577 6637-6646 VBD denotes indicated
T15578 6647-6651 IN denotes that
T15579 6652-6655 DT denotes the
T15580 6656-6669 JJ denotes non-canonical
T15581 6670-6677 NN denotes pathway
T15582 6678-6681 VBD denotes was
T15583 6682-6691 VBN denotes activated
T15584 6692-6698 IN denotes during
T15585 6699-6704 JJ denotes human
T15586 6705-6724 NN denotes monocyte-macrophage
T15587 6725-6740 NN denotes differentiation
T15588 6741-6742 NNP denotes [
T15589 6742-6744 CD denotes 48
T15590 6744-6745 NNP denotes ]
T15591 6745-6746 . denotes .
T15592 6747-6753 IN denotes During
T15593 6754-6758 DT denotes this
T15594 6759-6766 NN denotes process
T15595 6766-6767 , denotes ,
T15596 6768-6778 NN denotes expression
T15597 6779-6781 IN denotes of
T15598 6782-6786 NNP denotes IKKα
T15599 6787-6792 IN denotes among
T15600 6793-6798 JJ denotes other
T15601 6799-6807 NNS denotes proteins
T15602 6807-6808 , denotes ,
T15603 6809-6811 VBZ denotes is
T15604 6812-6820 JJ denotes elevated
T15605 6821-6828 VBG denotes leading
T15606 6829-6831 TO denotes to
T15607 6832-6841 VBN denotes increased
T15608 6842-6845 CD denotes p52
T15609 6846-6851 NNP denotes NF-κB
T15610 6852-6853 -LRB- denotes (
T15611 6853-6857 NNP denotes relB
T15612 6857-6858 -RRB- denotes )
T15613 6859-6869 NN denotes expression
T15614 6870-6877 IN denotes through
T15615 6878-6885 JJ denotes partial
T15616 6886-6897 JJ denotes proteolytic
T15617 6898-6909 NN denotes degradation
T15618 6910-6912 IN denotes of
T15619 6913-6916 DT denotes the
T15620 6917-6921 CD denotes p100
T15621 6922-6927 NN denotes NF-κB
T15622 6928-6935 NN denotes protein
T15623 6935-6936 . denotes .
T15624 6937-6941 RB denotes Thus
T15625 6941-6942 , denotes ,
T15626 6943-6945 PRP denotes it
T15627 6946-6948 VBZ denotes is
T15628 6949-6957 JJ denotes possible
T15629 6958-6962 IN denotes that
T15630 6963-6968 NNP denotes M-CSF
T15631 6969-6978 VBZ denotes regulates
T15632 6979-6987 NN denotes monocyte
T15633 6988-6996 NN denotes survival
T15634 6997-7004 IN denotes through
T15635 7005-7009 DT denotes both
T15636 7010-7013 DT denotes the
T15637 7014-7023 JJ denotes canonical
T15638 7024-7027 CC denotes and
T15639 7028-7041 JJ denotes non-canonical
T15640 7042-7047 NN denotes NF-κB
T15641 7048-7056 NNS denotes pathways
T15642 7056-7057 , denotes ,
T15643 7058-7063 WDT denotes which
T15644 7064-7068 MD denotes will
T15645 7069-7071 VB denotes be
T15646 7072-7073 DT denotes a
T15647 7074-7079 NN denotes focus
T15648 7080-7082 IN denotes in
T15649 7083-7089 JJ denotes future
T15650 7090-7098 NN denotes research
T15651 7098-7099 . denotes .
T15652 7100-7102 PRP denotes We
T15653 7103-7113 RB denotes previously
T15654 7114-7120 VBD denotes showed
T15655 7121-7125 IN denotes that
T15656 7126-7131 NNP denotes M-CSF
T15657 7132-7139 VBD denotes reduced
T15658 7140-7149 JJ denotes caspase-3
T15659 7150-7153 CC denotes and
T15660 7154-7156 JJ denotes -9
T15661 7157-7165 NN denotes activity
T15662 7166-7169 CC denotes and
T15663 7170-7179 VBD denotes prevented
T15664 7180-7188 NN denotes monocyte
T15665 7189-7198 NN denotes apoptosis
T15666 7199-7200 NNP denotes [
T15667 7200-7201 CD denotes 3
T15668 7201-7202 NNP denotes ]
T15669 7202-7203 . denotes .
T15670 7204-7208 DT denotes This
T15671 7209-7214 NN denotes study
T15672 7215-7222 VBZ denotes reveals
T15673 7223-7227 IN denotes that
T15674 7228-7237 NN denotes treatment
T15675 7238-7240 IN denotes of
T15676 7241-7250 NNS denotes monocytes
T15677 7251-7255 IN denotes with
T15678 7256-7268 JJ denotes conventional
T15679 7269-7272 NNP denotes PKC
T15680 7273-7283 NNS denotes inhibitors
T15681 7283-7284 , denotes ,
T15682 7285-7287 CC denotes or
T15683 7288-7302 NN denotes overexpression
T15684 7303-7305 IN denotes of
T15685 7306-7322 JJ denotes kinase-deficient
T15686 7323-7327 NNP denotes PKCα
T15687 7328-7335 VBD denotes blocked
T15688 7336-7349 JJ denotes M-CSF-induced
T15689 7350-7354 NN denotes cell
T15690 7355-7363 NN denotes survival
T15691 7363-7364 . denotes .
T15692 7365-7368 PRP$ denotes Our
T15693 7369-7373 NNS denotes data
T15694 7374-7382 VBD denotes revealed
T15695 7383-7387 IN denotes that
T15696 7388-7400 JJ denotes conventional
T15697 7401-7405 NNS denotes PKCs
T15698 7406-7409 VBP denotes are
T15699 7410-7418 RB denotes upstream
T15700 7419-7421 IN denotes of
T15701 7422-7427 JJ denotes NF-κB
T15702 7428-7438 NN denotes activation
T15703 7439-7441 IN denotes in
T15704 7442-7450 NN denotes response
T15705 7451-7453 TO denotes to
T15706 7454-7459 NNP denotes M-CSF
T15707 7460-7463 CC denotes and
T15708 7464-7471 VB denotes mediate
T15709 7472-7490 JJ denotes post-translational
T15710 7491-7501 NN denotes activation
T15711 7502-7504 IN denotes of
T15712 7505-7510 NNP denotes NF-κB
T15713 7511-7514 CD denotes p65
T15714 7515-7517 IN denotes by
T15715 7518-7533 VBG denotes phosphorylating
T15716 7534-7540 NNP denotes Ser276
T15717 7541-7543 TO denotes to
T15718 7544-7552 VB denotes regulate
T15719 7553-7557 NN denotes gene
T15720 7558-7571 NN denotes transcription
T15721 7572-7575 CC denotes and
T15722 7576-7580 NN denotes cell
T15723 7581-7589 NN denotes survival
T15724 7589-7590 . denotes .
T15725 7591-7595 RB denotes Thus
T15726 7595-7596 , denotes ,
T15727 7597-7600 PRP$ denotes our
T15728 7601-7612 NN denotes observation
T15729 7613-7616 MD denotes may
T15730 7617-7624 VB denotes provide
T15731 7625-7632 NN denotes insight
T15732 7633-7635 IN denotes in
T15733 7636-7645 JJ denotes potential
T15734 7646-7657 JJ denotes therapeutic
T15735 7658-7665 NNS denotes targets
T15736 7666-7669 IN denotes for
T15737 7670-7682 JJ denotes inflammatory
T15738 7683-7691 NNS denotes diseases
T15739 7691-7692 . denotes .
T26848 1944-1952 VBN denotes Proposed
T26849 1953-1958 NN denotes model
T26850 1959-1962 IN denotes for
T26851 1963-1976 JJ denotes M-CSF-induced
T26852 1977-1985 NN denotes monocyte
T26853 1986-1994 NN denotes survival
T26854 1995-1998 IN denotes via
T26855 1999-2002 NNP denotes PKC
T26856 2003-2013 NN denotes regulation
T26857 2014-2016 IN denotes by
T26858 2017-2027 VBG denotes activating
T26859 2028-2033 NNP denotes NF-κB
T26860 2034-2037 CD denotes p65
T26861 2038-2053 NN denotes phosphorylation
T26862 2054-2056 IN denotes at
T26863 2057-2063 NNP denotes Ser276
T26864 2063-2064 . denotes .
R10609 T14526 T14527 amod intracellular,signaling
R10610 T14527 T14525 dobj signaling,regulating
R10611 T14528 T14527 punct ",",signaling
R10612 T14529 T14530 compound stress,response
R10613 T14530 T14527 conj response,signaling
R10614 T14531 T14530 punct ",",response
R10615 T14532 T14530 conj proliferation,response
R10616 T14533 T14532 punct ",",proliferation
R10617 T14534 T14532 conj survival,proliferation
R10618 T14535 T14534 punct ",",survival
R10619 T14536 T14534 conj differentiation,survival
R10620 T14537 T14536 cc and,differentiation
R10621 T14538 T14536 conj inflammation,differentiation
R10622 T14539 T14536 conj [,differentiation
R10623 T14540 T14541 nummod 8,]
R10624 T14541 T14530 npadvmod ],response
R10626 T14543 T14544 aux To,regulate
R10627 T14544 T14551 advcl regulate,translocate
R10628 T14545 T14546 compound gene,transcription
R10629 T14546 T14544 dobj transcription,regulate
R10630 T14547 T14546 punct ",",transcription
R10631 T14548 T14551 npadvmod NF-κB,translocate
R10632 T14549 T14550 nummod p50/p65,heterodimers
R10633 T14550 T14551 nsubj heterodimers,translocate
R10634 T14551 T14563 dep translocate,is
R10635 T14552 T14551 prep to,translocate
R10636 T14553 T14554 det the,nucleus
R10637 T14554 T14552 pobj nucleus,to
R10638 T14555 T14554 prep from,nucleus
R10639 T14556 T14557 det the,cytoplasm
R10640 T14557 T14555 pobj cytoplasm,from
R10641 T14558 T14551 punct ",",translocate
R10642 T14559 T14551 advmod however,translocate
R10643 T14560 T14563 punct ",",is
R10644 T14561 T14562 poss their,translocation
R10645 T14562 T14563 nsubj translocation,is
R10646 T14563 T14563 ROOT is,is
R10647 T14564 T14563 neg not,is
R10648 T14565 T14563 acomp sufficient,is
R10649 T14566 T14567 aux to,activate
R10650 T14567 T14565 xcomp activate,sufficient
R10651 T14568 T14569 compound gene,transcription
R10652 T14569 T14567 dobj transcription,activate
R10653 T14570 T14563 punct .,is
R10654 T14571 T14572 amod Post-translational,modification
R10655 T14572 T14582 nsubj modification,contributes
R10656 T14573 T14572 prep of,modification
R10657 T14574 T14575 amod NF-κB,heterodimers
R10658 T14575 T14573 pobj heterodimers,of
R10659 T14576 T14577 amod such,as
R10660 T14577 T14575 prep as,heterodimers
R10661 T14578 T14577 pobj phosphorylation,as
R10662 T14579 T14578 cc or,phosphorylation
R10663 T14580 T14578 conj acetylation,phosphorylation
R10664 T14581 T14582 advmod also,contributes
R10665 T14582 T14582 ROOT contributes,contributes
R10666 T14583 T14582 prep to,contributes
R10667 T14584 T14586 poss its,activity
R10668 T14585 T14586 amod transcriptional,activity
R10669 T14586 T14583 pobj activity,to
R10670 T14587 T14589 nmod [,]
R10671 T14588 T14589 nummod 41,]
R10672 T14589 T14586 appos ],activity
R10673 T14590 T14589 punct ",",]
R10674 T14591 T14593 nmod [,]
R10675 T14592 T14593 nummod 42,]
R10676 T14593 T14589 conj ],]
R10677 T14594 T14593 punct ",",]
R10678 T14595 T14597 det [,]
R10679 T14596 T14597 nummod 43,]
R10680 T14597 T14593 appos ],]
R10681 T14598 T14582 punct .,contributes
R10682 T14599 T14626 mark Because,sought
R10683 T14600 T14602 amod NF-κB,translocates
R10684 T14601 T14602 advmod constitutively,translocates
R10685 T14602 T14626 advcl translocates,sought
R10686 T14603 T14602 prep to,translocates
R10687 T14604 T14605 det the,nucleus
R10688 T14605 T14603 pobj nucleus,to
R10689 T14606 T14605 prep in,nucleus
R10690 T14607 T14608 amod monocytic,lineage
R10691 T14608 T14606 pobj lineage,in
R10692 T14609 T14611 nmod [,]
R10693 T14610 T14611 nummod 13,]
R10694 T14611 T14605 appos ],nucleus
R10695 T14612 T14602 cc and,translocates
R10696 T14613 T14602 conj activates,translocates
R10697 T14614 T14615 compound gene,transcription
R10698 T14615 T14613 dobj transcription,activates
R10699 T14616 T14615 cc and,transcription
R10700 T14617 T14615 conj survival,transcription
R10701 T14618 T14615 prep in,transcription
R10702 T14619 T14620 amod murine,macrophages
R10703 T14620 T14618 pobj macrophages,in
R10704 T14621 T14623 nmod [,]
R10705 T14622 T14623 nummod 11,]
R10706 T14623 T14613 dobj ],activates
R10707 T14624 T14626 punct ",",sought
R10708 T14625 T14626 nsubj we,sought
R10709 T14626 T14626 ROOT sought,sought
R10710 T14627 T14628 aux to,determine
R10711 T14628 T14626 xcomp determine,sought
R10712 T14629 T14634 advmod how,activity
R10713 T14630 T14634 amod M-CSF,activity
R10714 T14631 T14634 amod affected,activity
R10715 T14632 T14634 nmod NF-κB,activity
R10716 T14633 T14634 compound transcriptional,activity
R10717 T14634 T14628 dobj activity,determine
R10718 T14635 T14634 prep in,activity
R10719 T14636 T14637 amod human,MDMs
R10720 T14637 T14635 pobj MDMs,in
R10721 T14638 T14634 cc and,activity
R10722 T14639 T14642 mark whether,regulated
R10723 T14640 T14641 det this,activation
R10724 T14641 T14642 nsubj activation,regulated
R10725 T14642 T14634 conj regulated,activity
R10726 T14643 T14644 poss their,survival
R10727 T14644 T14642 dobj survival,regulated
R10728 T14645 T14626 punct .,sought
R10729 T14646 T14648 det The,study
R10730 T14647 T14648 amod present,study
R10731 T14648 T14649 nsubj study,demonstrated
R10732 T14649 T14649 ROOT demonstrated,demonstrated
R10733 T14650 T14652 mark that,stimulated
R10734 T14651 T14652 nsubj M-CSF,stimulated
R10735 T14652 T14649 ccomp stimulated,demonstrated
R10736 T14653 T14654 compound PKCα,kinase
R10737 T14654 T14655 compound kinase,upstream
R10738 T14655 T14652 dobj upstream,stimulated
R10739 T14656 T14655 prep of,upstream
R10740 T14657 T14659 amod NF-κB,activity
R10741 T14658 T14659 amod transcriptional,activity
R10742 T14659 T14656 pobj activity,of
R10743 T14660 T14659 prep in,activity
R10744 T14661 T14663 amod primary,MDMs
R10745 T14662 T14663 amod human,MDMs
R10746 T14663 T14660 pobj MDMs,in
R10747 T14664 T14663 cc and,MDMs
R10748 T14665 T14663 conj RAW,MDMs
R10749 T14666 T14667 nummod 264.7,cells
R10750 T14667 T14659 appos cells,activity
R10751 T14668 T14649 punct .,demonstrated
R10752 T14669 T14670 nsubj We,showed
R10753 T14670 T14685 ccomp showed,blocked
R10754 T14671 T14670 dobj inhibition,showed
R10755 T14672 T14671 prep of,inhibition
R10756 T14673 T14674 amod conventional,PKCs
R10757 T14674 T14672 pobj PKCs,of
R10758 T14675 T14670 prep by,showed
R10759 T14676 T14677 compound PKC,inhibitors
R10760 T14677 T14675 pobj inhibitors,by
R10761 T14678 T14677 punct ",",inhibitors
R10762 T14679 T14685 intj kinase,blocked
R10763 T14680 T14685 advmod deficient,blocked
R10764 T14681 T14685 nsubj PKCα,blocked
R10765 T14682 T14681 cc or,PKCα
R10766 T14683 T14684 compound PKCα,siRNA
R10767 T14684 T14681 conj siRNA,PKCα
R10768 T14685 T14685 ROOT blocked,blocked
R10769 T14686 T14688 amod M-CSF-induced,survival
R10770 T14687 T14688 compound cell,survival
R10771 T14688 T14685 dobj survival,blocked
R10772 T14689 T14688 cc and,survival
R10773 T14690 T14692 amod NF-κB-regulated,expression
R10774 T14691 T14692 compound gene,expression
R10775 T14692 T14688 conj expression,survival
R10776 T14693 T14685 punct .,blocked
R10777 T14694 T14695 det This,block
R10778 T14695 T14695 ROOT block,block
R10779 T14696 T14695 acl correlated,block
R10780 T14697 T14696 prep with,correlated
R10781 T14698 T14699 det a,reduction
R10782 T14699 T14697 pobj reduction,with
R10783 T14700 T14699 prep in,reduction
R10784 T14701 T14702 amod M-CSF-induced,phosphorylation
R10785 T14702 T14700 pobj phosphorylation,in
R10786 T14703 T14702 prep of,phosphorylation
R10787 T14704 T14705 compound NF-κB,p65
R10788 T14705 T14703 pobj p65,of
R10789 T14706 T14699 prep at,reduction
R10790 T14707 T14706 pobj Ser276,at
R10791 T14708 T14695 punct .,block
R10792 T14709 T14719 advmod Consistent,inhibited
R10793 T14710 T14709 prep with,Consistent
R10794 T14711 T14712 det these,findings
R10795 T14712 T14710 pobj findings,with
R10796 T14713 T14717 det the,constructs
R10797 T14714 T14717 amod dominant,constructs
R10798 T14715 T14717 amod negative,constructs
R10799 T14716 T14717 compound PKCα,constructs
R10800 T14717 T14719 nsubj constructs,inhibited
R10801 T14718 T14719 advmod also,inhibited
R10802 T14719 T14719 ROOT inhibited,inhibited
R10803 T14720 T14722 nsubj NF-κB,phosphorylation
R10804 T14721 T14722 nummod p65,phosphorylation
R10805 T14722 T14719 dobj phosphorylation,inhibited
R10806 T14723 T14722 prep at,phosphorylation
R10807 T14724 T14723 pobj Ser276,at
R10808 T14725 T14723 cc but,at
R10809 T14726 T14729 neg not,resulting
R10810 T14727 T14726 prep at,not
R10811 T14728 T14727 pobj Ser536,at
R10812 T14729 T14719 advcl resulting,inhibited
R10813 T14730 T14729 prep in,resulting
R10814 T14731 T14734 amod reduced,activation
R10815 T14732 T14734 nmod NF-κB,activation
R10816 T14733 T14734 amod transcriptional,activation
R10817 T14734 T14730 pobj activation,in
R10818 T14735 T14734 cc and,activation
R10819 T14736 T14737 compound M-CSF-induced,MDM
R10820 T14737 T14738 compound MDM,survival
R10821 T14738 T14734 conj survival,activation
R10822 T14739 T14719 punct .,inhibited
R10823 T14740 T14744 det A,model
R10824 T14741 T14744 amod simplified,model
R10825 T14742 T14744 amod proposed,model
R10826 T14743 T14744 compound cartoon,model
R10827 T14744 T14748 nsubj model,demonstrates
R10828 T14745 T14744 prep in,model
R10829 T14746 T14745 pobj Figure,in
R10830 T14747 T14746 nummod 9,Figure
R10831 T14748 T14748 ROOT demonstrates,demonstrates
R10832 T14749 T14751 mark that,induced
R10833 T14750 T14751 nsubj M-CSF,induced
R10834 T14751 T14748 ccomp induced,demonstrates
R10835 T14752 T14753 compound monocytes,survival
R10836 T14753 T14751 dobj survival,induced
R10837 T14754 T14755 auxpass is,regulated
R10838 T14755 T14751 conj regulated,induced
R10839 T14756 T14755 prep by,regulated
R10840 T14757 T14756 pcomp activating,by
R10841 T14758 T14760 nsubj NF-κB,phosphorylation
R10842 T14759 T14760 nummod p65,phosphorylation
R10843 T14760 T14757 dobj phosphorylation,activating
R10844 T14761 T14760 prep at,phosphorylation
R10845 T14762 T14761 pobj Ser276,at
R10846 T14763 T14757 prep via,activating
R10847 T14764 T14763 pobj PKC,via
R10848 T14765 T14748 punct .,demonstrates
R10849 T14766 T14780 advmod Finally,confirmed
R10850 T14767 T14780 punct ",",confirmed
R10851 T14768 T14780 prep in,confirmed
R10852 T14769 T14777 det a,line
R10853 T14770 T14777 nmod NF-κB,line
R10854 T14771 T14772 nummod p65,−
R10855 T14772 T14773 nummod −,/
R10856 T14773 T14777 nmod /,line
R10857 T14774 T14777 nmod −,line
R10858 T14775 T14777 compound fibroblast,line
R10859 T14776 T14777 compound cell,line
R10860 T14777 T14768 pobj line,in
R10861 T14778 T14780 punct ",",confirmed
R10862 T14779 T14780 nsubj we,confirmed
R10863 T14780 T14780 ROOT confirmed,confirmed
R10864 T14781 T14788 mark that,is
R10865 T14782 T14784 det the,residue
R10866 T14783 T14784 compound Ser276,residue
R10867 T14784 T14788 nsubj residue,is
R10868 T14785 T14784 prep of,residue
R10869 T14786 T14785 pobj NF-κB,of
R10870 T14787 T14786 nummod p65,NF-κB
R10871 T14788 T14780 ccomp is,confirmed
R10872 T14789 T14788 acomp important,is
R10873 T14790 T14789 cc and,important
R10874 T14791 T14789 conj essential,important
R10875 T14792 T14788 prep for,is
R10876 T14793 T14794 compound PKC,modulation
R10877 T14794 T14792 pobj modulation,for
R10878 T14795 T14794 prep of,modulation
R10879 T14796 T14797 amod NF-κB,activity
R10880 T14797 T14795 pobj activity,of
R10881 T14798 T14780 punct .,confirmed
R10882 T14799 T14800 advmod More,compelling
R10883 T14800 T14801 acomp compelling,is
R10884 T14801 T14801 ROOT is,is
R10885 T14802 T14804 mark that,observed
R10886 T14803 T14804 nsubj we,observed
R10887 T14804 T14801 ccomp observed,is
R10888 T14805 T14807 det a,regulation
R10889 T14806 T14807 amod similar,regulation
R10890 T14807 T14804 dobj regulation,observed
R10891 T14808 T14807 prep between,regulation
R10892 T14809 T14812 nummod two,lineages
R10893 T14810 T14812 amod different,lineages
R10894 T14811 T14812 compound cell,lineages
R10895 T14812 T14808 pobj lineages,between
R10896 T14813 T14812 prep in,lineages
R10897 T14814 T14815 poss our,study
R10898 T14815 T14813 pobj study,in
R10899 T14816 T14801 punct .,is
R10900 T14817 T14818 amod Post-translational,modification
R10901 T14818 T14822 nsubj modification,regulates
R10902 T14819 T14818 prep of,modification
R10903 T14820 T14819 pobj NF-κB,of
R10904 T14821 T14820 nummod p65,NF-κB
R10905 T14822 T14822 ROOT regulates,regulates
R10906 T14823 T14824 poss its,activating
R10907 T14824 T14822 dobj activating,regulates
R10908 T14825 T14824 cc or,activating
R10909 T14826 T14824 conj repressing,activating
R10910 T14827 T14826 dobj effects,repressing
R10911 T14828 T14827 prep on,effects
R10912 T14829 T14830 compound gene,expression
R10913 T14830 T14828 pobj expression,on
R10914 T14831 T14822 punct .,regulates
R10915 T14832 T14835 prep Among,reported
R10916 T14833 T14834 det the,seven
R10917 T14834 T14835 nsubj seven,reported
R10918 T14835 T14835 ROOT reported,reported
R10919 T14836 T14840 amod putative,sites
R10920 T14837 T14840 nmod NF-κB,sites
R10921 T14838 T14840 nummod p65,sites
R10922 T14839 T14840 compound phosphorylation,sites
R10923 T14840 T14835 dobj sites,reported
R10924 T14841 T14840 punct ",",sites
R10925 T14842 T14843 nummod five,increase
R10926 T14843 T14840 appos increase,sites
R10927 T14844 T14845 amod nuclear,translocation
R10928 T14845 T14843 appos translocation,increase
R10929 T14846 T14843 punct ",",increase
R10930 T14847 T14848 nsubj DNA,binding
R10931 T14848 T14852 amod binding,activity
R10932 T14849 T14848 cc and,binding
R10933 T14850 T14848 conj NF-κB,binding
R10934 T14851 T14852 amod transcriptional,activity
R10935 T14852 T14855 nsubj activity,]
R10936 T14853 T14855 nmod [,]
R10937 T14854 T14855 nummod 17,]
R10938 T14855 T14843 appos ],increase
R10939 T14856 T14835 punct .,reported
R10940 T14857 T14865 advmod Similar,found
R10941 T14858 T14857 prep to,Similar
R10942 T14859 T14860 poss our,finding
R10943 T14860 T14858 pobj finding,to
R10944 T14861 T14865 punct ",",found
R10945 T14862 T14864 compound Zhong,al.
R10946 T14863 T14864 compound et,al.
R10947 T14864 T14865 nsubj al.,found
R10948 T14865 T14865 ROOT found,found
R10949 T14866 T14874 mark that,is
R10950 T14867 T14874 prep in,is
R10951 T14868 T14867 pobj response,in
R10952 T14869 T14868 prep to,response
R10953 T14870 T14869 pobj LPS,to
R10954 T14871 T14870 punct ",",LPS
R10955 T14872 T14873 compound NF-κB,p65
R10956 T14873 T14874 nsubj p65,is
R10957 T14874 T14865 ccomp is,found
R10958 T14875 T14874 attr phosphorylated,is
R10959 T14876 T14875 prep at,phosphorylated
R10960 T14877 T14881 det the,residue
R10961 T14878 T14879 advmod highly,conserved
R10962 T14879 T14881 amod conserved,residue
R10963 T14880 T14881 compound Ser276,residue
R10964 T14881 T14876 pobj residue,at
R10965 T14882 T14875 agent by,phosphorylated
R10966 T14883 T14885 det the,subunit
R10967 T14884 T14885 amod catalytic,subunit
R10968 T14885 T14882 pobj subunit,by
R10969 T14886 T14885 prep of,subunit
R10970 T14887 T14888 compound PKA,[
R10971 T14888 T14886 pobj [,of
R10972 T14889 T14890 nummod 16,]
R10973 T14890 T14888 appos ],[
R10974 T14891 T14865 punct .,found
R10975 T14892 T14900 prep In,phosphorylated
R10976 T14893 T14892 pobj addition,In
R10977 T14894 T14893 prep to,addition
R10978 T14895 T14894 pobj PKA,to
R10979 T14896 T14900 punct ",",phosphorylated
R10980 T14897 T14900 nsubjpass Ser276,phosphorylated
R10981 T14898 T14900 aux can,phosphorylated
R10982 T14899 T14900 auxpass be,phosphorylated
R10983 T14900 T14900 ROOT phosphorylated,phosphorylated
R10984 T14901 T14900 agent by,phosphorylated
R10985 T14902 T14901 pobj MSK1,by
R10986 T14903 T14900 prep in,phosphorylated
R10987 T14904 T14905 det the,nucleus
R10988 T14905 T14903 pobj nucleus,in
R10989 T14906 T14905 prep upon,nucleus
R10990 T14907 T14908 compound TNFα,treatment
R10991 T14908 T14906 pobj treatment,upon
R10992 T14909 T14911 nmod [,]
R10993 T14910 T14911 nummod 18,]
R10994 T14911 T14908 appos ],treatment
R10995 T14912 T14900 punct .,phosphorylated
R10996 T14913 T14919 nsubj Phosphorylation,occurs
R10997 T14914 T14913 prep of,Phosphorylation
R10998 T14915 T14916 compound NF-κB,p65
R10999 T14916 T14914 pobj p65,of
R11000 T14917 T14913 prep at,Phosphorylation
R11001 T14918 T14917 pobj Ser536,at
R11002 T14919 T14919 ROOT occurs,occurs
R11003 T14920 T14919 prep in,occurs
R11004 T14921 T14920 pobj response,in
R11005 T14922 T14921 prep to,response
R11006 T14923 T14925 amod many,stimuli
R11007 T14924 T14925 amod inflammatory,stimuli
R11008 T14925 T14922 pobj stimuli,to
R11009 T14926 T14928 advmod as,as
R11010 T14927 T14928 advmod well,as
R11011 T14928 T14925 cc as,stimuli
R11012 T14929 T14925 conj kinases,stimuli
R11013 T14930 T14929 punct ",",kinases
R11014 T14931 T14929 conj IKKα,kinases
R11015 T14932 T14931 punct ",",IKKα
R11016 T14933 T14931 conj IKKβ,IKKα
R11017 T14934 T14933 cc and,IKKβ
R11018 T14935 T14933 conj RSK1,IKKβ
R11019 T14936 T14933 conj [,IKKβ
R11020 T14937 T14938 nummod 17,]
R11021 T14938 T14933 conj ],IKKβ
R11022 T14939 T14938 punct ",",]
R11023 T14940 T14942 nmod [,]
R11024 T14941 T14942 nummod 18,]
R11025 T14942 T14938 conj ],]
R11026 T14943 T14942 punct ",",]
R11027 T14944 T14946 nmod [,]
R11028 T14945 T14946 nummod 19,]
R11029 T14946 T14942 conj ],]
R11030 T14947 T14946 punct ",",]
R11031 T14948 T14946 conj [,]
R11032 T14949 T14950 nummod 20,]
R11033 T14950 T14946 conj ],]
R11034 T14951 T14950 punct ",",]
R11035 T14952 T14950 conj [,]
R11036 T14953 T14954 nummod 21,]
R11037 T14954 T14950 conj ],]
R11038 T14955 T14919 punct .,occurs
R11039 T14956 T14968 advmod Notably,revealed
R11040 T14957 T14968 punct ",",revealed
R11041 T14958 T14968 prep in,revealed
R11042 T14959 T14958 pobj addition,in
R11043 T14960 T14959 prep to,addition
R11044 T14961 T14960 pcomp phosphorylating,to
R11045 T14962 T14961 dobj Ser276,phosphorylating
R11046 T14963 T14962 prep of,Ser276
R11047 T14964 T14963 pobj NF-κB,of
R11048 T14965 T14968 punct ",",revealed
R11049 T14966 T14967 poss our,study
R11050 T14967 T14968 nsubj study,revealed
R11051 T14968 T14968 ROOT revealed,revealed
R11052 T14969 T14972 mark that,modulated
R11053 T14970 T14972 nsubj M-CSF,modulated
R11054 T14971 T14972 advmod also,modulated
R11055 T14972 T14968 ccomp modulated,revealed
R11056 T14973 T14974 det the,phosphorylation
R11057 T14974 T14972 dobj phosphorylation,modulated
R11058 T14975 T14974 prep of,phosphorylation
R11059 T14976 T14979 det the,subunit
R11060 T14977 T14979 nmod NF-κB,subunit
R11061 T14978 T14979 nummod p65,subunit
R11062 T14979 T14975 pobj subunit,of
R11063 T14980 T14979 prep at,subunit
R11064 T14981 T14980 pobj Ser536,at
R11065 T14982 T14972 punct ",",modulated
R11066 T14983 T14972 advmod however,modulated
R11067 T14984 T14972 punct ",",modulated
R11068 T14985 T14986 compound PKC,inhibitors
R11069 T14986 T14972 dobj inhibitors,modulated
R11070 T14987 T14972 cc or,modulated
R11071 T14988 T14972 conj kinase,modulated
R11072 T14989 T14991 amod deficient,constructs
R11073 T14990 T14991 compound PKCα,constructs
R11074 T14991 T14988 dobj constructs,kinase
R11075 T14992 T14994 aux did,affect
R11076 T14993 T14994 neg not,affect
R11077 T14994 T14972 conj affect,modulated
R11078 T14995 T14997 det this,event
R11079 T14996 T14997 amod phosphorylation,event
R11080 T14997 T14994 dobj event,affect
R11081 T14998 T14968 punct .,revealed
R11082 T14999 T15014 advmod Moreover,reduce
R11083 T15000 T15014 punct ",",reduce
R11084 T15001 T15002 amod mutant,constructs
R11085 T15002 T15014 nsubj constructs,reduce
R11086 T15003 T15002 acl containing,constructs
R11087 T15004 T15006 det a,mutation
R11088 T15005 T15006 compound point,mutation
R11089 T15006 T15003 dobj mutation,containing
R11090 T15007 T15006 prep at,mutation
R11091 T15008 T15007 pobj Ser536,at
R11092 T15009 T15008 prep of,Ser536
R11093 T15010 T15009 pobj NF-κB,of
R11094 T15011 T15010 nummod p65,NF-κB
R11095 T15012 T15014 aux did,reduce
R11096 T15013 T15014 neg not,reduce
R11097 T15014 T15014 ROOT reduce,reduce
R11098 T15015 T15016 amod NF-κB,activity
R11099 T15016 T15014 dobj activity,reduce
R11100 T15017 T15014 prep in,reduce
R11101 T15018 T15017 pobj cells,in
R11102 T15019 T15018 acl lacking,cells
R11103 T15020 T15022 amod endogenous,p65
R11104 T15021 T15022 compound NF-κB,p65
R11105 T15022 T15019 dobj p65,lacking
R11106 T15023 T15014 punct ",",reduce
R11107 T15024 T15029 mark while,construct
R11108 T15025 T15028 det the,276S/A
R11109 T15026 T15028 nmod NF-κB,276S/A
R11110 T15027 T15028 nummod p65,276S/A
R11111 T15028 T15029 nsubj 276S/A,construct
R11112 T15029 T15014 advcl construct,reduce
R11113 T15030 T15031 aux did,reduce
R11114 T15031 T15014 conj reduce,reduce
R11115 T15032 T15033 compound NF-κB,activity
R11116 T15033 T15031 dobj activity,reduce
R11117 T15034 T15031 prep in,reduce
R11118 T15035 T15036 det these,cells
R11119 T15036 T15034 pobj cells,in
R11120 T15037 T15014 punct .,reduce
R11121 T15038 T15046 advmod Therefore,is
R11122 T15039 T15046 punct ",",is
R11123 T15040 T15042 amod specific,modification
R11124 T15041 T15042 amod post-translational,modification
R11125 T15042 T15046 nsubj modification,is
R11126 T15043 T15042 prep of,modification
R11127 T15044 T15043 pobj NF-κB,of
R11128 T15045 T15044 nummod p65,NF-κB
R11129 T15046 T15046 ROOT is,is
R11130 T15047 T15046 acomp likely,is
R11131 T15048 T15049 aux to,regulate
R11132 T15049 T15047 xcomp regulate,likely
R11133 T15050 T15051 amod transcriptional,activation
R11134 T15051 T15049 dobj activation,regulate
R11135 T15052 T15049 prep in,regulate
R11136 T15053 T15052 pobj response,in
R11137 T15054 T15053 prep to,response
R11138 T15055 T15056 amod specific,stimuli
R11139 T15056 T15054 pobj stimuli,to
R11140 T15057 T15059 nmod [,]
R11141 T15058 T15059 nummod 15,]
R11142 T15059 T15056 appos ],stimuli
R11143 T15060 T15059 punct ",",]
R11144 T15061 T15063 nmod [,]
R11145 T15062 T15063 nummod 43,]
R11146 T15063 T15059 appos ],]
R11147 T15064 T15046 punct .,is
R11148 T15065 T15066 nsubj It,is
R11149 T15066 T15066 ROOT is,is
R11150 T15067 T15066 acomp notable,is
R11151 T15068 T15070 mark that,activated
R11152 T15069 T15070 nsubj M-CSF,activated
R11153 T15070 T15066 ccomp activated,is
R11154 T15071 T15070 dobj NF-κB,activated
R11155 T15072 T15074 nummod p65,phosphorylation
R11156 T15073 T15074 compound Ser276,phosphorylation
R11157 T15074 T15071 appos phosphorylation,NF-κB
R11158 T15075 T15074 cc and,phosphorylation
R11159 T15076 T15077 amod transcriptional,activation
R11160 T15077 T15074 conj activation,phosphorylation
R11161 T15078 T15077 prep in,activation
R11162 T15079 T15081 det a,manner
R11163 T15080 T15081 amod PKCα-dependent,manner
R11164 T15081 T15078 pobj manner,in
R11165 T15082 T15066 punct .,is
R11166 T15083 T15084 nsubj PKCα,is
R11167 T15084 T15084 ROOT is,is
R11168 T15085 T15086 det a,member
R11169 T15086 T15084 attr member,is
R11170 T15087 T15086 prep of,member
R11171 T15088 T15091 det the,family
R11172 T15089 T15091 amod conventional,family
R11173 T15090 T15091 compound PKC,family
R11174 T15091 T15087 pobj family,of
R11175 T15092 T15091 prep of,family
R11176 T15093 T15094 compound protein,kinases
R11177 T15094 T15092 pobj kinases,of
R11178 T15095 T15096 nsubj that,are
R11179 T15096 T15094 relcl are,kinases
R11180 T15097 T15096 acomp critical,are
R11181 T15098 T15097 prep for,critical
R11182 T15099 T15100 compound cell,growth
R11183 T15100 T15098 pobj growth,for
R11184 T15101 T15100 punct ",",growth
R11185 T15102 T15100 conj differentiation,growth
R11186 T15103 T15102 cc and,differentiation
R11187 T15104 T15105 compound cell,death
R11188 T15105 T15102 conj death,differentiation
R11189 T15106 T15084 punct .,is
R11190 T15107 T15109 nsubj PKCα,modulates
R11191 T15108 T15109 advmod primarily,modulates
R11192 T15109 T15109 ROOT modulates,modulates
R11193 T15110 T15109 dobj anti-apoptotic,modulates
R11194 T15111 T15110 cc and,anti-apoptotic
R11195 T15112 T15110 conj proliferation,anti-apoptotic
R11196 T15113 T15109 conj signals,modulates
R11197 T15114 T15113 acl following,signals
R11198 T15115 T15116 amod cytokine,treatment
R11199 T15116 T15114 dobj treatment,following
R11200 T15117 T15116 prep in,treatment
R11201 T15118 T15120 amod various,types
R11202 T15119 T15120 compound cell,types
R11203 T15120 T15117 pobj types,in
R11204 T15121 T15123 nmod [,]
R11205 T15122 T15123 nummod 42,]
R11206 T15123 T15116 nmod ],treatment
R11207 T15124 T15109 punct .,modulates
R11208 T15125 T15128 nsubj Expression,attenuates
R11209 T15126 T15125 prep of,Expression
R11210 T15127 T15126 pobj PKCα,of
R11211 T15128 T15128 ROOT attenuates,attenuates
R11212 T15129 T15128 dobj apoptosis,attenuates
R11213 T15130 T15128 prep in,attenuates
R11214 T15131 T15134 amod many,types
R11215 T15132 T15134 amod different,types
R11216 T15133 T15134 compound cell,types
R11217 T15134 T15130 pobj types,in
R11218 T15135 T15128 punct ",",attenuates
R11219 T15136 T15140 mark while,potentiates
R11220 T15137 T15138 compound PKCα,inhibition
R11221 T15138 T15140 nsubj inhibition,potentiates
R11222 T15139 T15140 advmod generally,potentiates
R11223 T15140 T15128 advcl potentiates,attenuates
R11224 T15141 T15142 compound apoptosis,[
R11225 T15142 T15140 dobj [,potentiates
R11226 T15143 T15144 nummod 42,]
R11227 T15144 T15142 appos ],[
R11228 T15145 T15128 punct .,attenuates
R11229 T15146 T15160 prep In,was
R11230 T15147 T15148 poss our,studies
R11231 T15148 T15146 pobj studies,In
R11232 T15149 T15148 acl using,studies
R11233 T15150 T15152 amod conventional,inhibitors
R11234 T15151 T15152 compound PKC,inhibitors
R11235 T15152 T15149 dobj inhibitors,using
R11236 T15153 T15152 cc and,inhibitors
R11237 T15154 T15157 amod dominant,constructs
R11238 T15155 T15157 amod negative,constructs
R11239 T15156 T15157 compound PKCα,constructs
R11240 T15157 T15152 conj constructs,inhibitors
R11241 T15158 T15160 punct ",",was
R11242 T15159 T15160 nsubj PKCα,was
R11243 T15160 T15160 ROOT was,was
R11244 T15161 T15160 acomp critical,was
R11245 T15162 T15161 prep in,critical
R11246 T15163 T15165 amod M-CSF-induced,survival
R11247 T15164 T15165 compound macrophage,survival
R11248 T15165 T15162 pobj survival,in
R11249 T15166 T15160 prep by,was
R11250 T15167 T15166 pcomp inducing,by
R11251 T15168 T15169 compound Ser276,phosphorylation
R11252 T15169 T15167 dobj phosphorylation,inducing
R11253 T15170 T15169 prep of,phosphorylation
R11254 T15171 T15170 pobj NF-κB,of
R11255 T15172 T15171 nummod p65,NF-κB
R11256 T15173 T15169 prep in,phosphorylation
R11257 T15174 T15177 preconj both,MDMs
R11258 T15175 T15177 amod primary,MDMs
R11259 T15176 T15177 amod human,MDMs
R11260 T15177 T15173 pobj MDMs,in
R11261 T15178 T15177 cc and,MDMs
R11262 T15179 T15177 conj Raw,MDMs
R11263 T15180 T15181 nummod 264.7,cells
R11264 T15181 T15177 conj cells,MDMs
R11265 T15182 T15160 punct .,was
R11266 T15183 T15185 nsubj We,demonstrated
R11267 T15184 T15185 advmod also,demonstrated
R11268 T15185 T15185 ROOT demonstrated,demonstrated
R11269 T15186 T15187 compound PKC,inhibition
R11270 T15187 T15188 nsubj inhibition,downregulated
R11271 T15188 T15185 ccomp downregulated,demonstrated
R11272 T15189 T15188 dobj NF-κB-induction,downregulated
R11273 T15190 T15189 prep of,NF-κB-induction
R11274 T15191 T15193 det the,gene
R11275 T15192 T15193 compound anti-apoptotic,gene
R11276 T15193 T15194 compound gene,BCL-xL
R11277 T15194 T15190 pobj BCL-xL,of
R11278 T15195 T15185 punct .,demonstrated
R11279 T15196 T15202 advcl Consistent,reported
R11280 T15197 T15196 prep with,Consistent
R11281 T15198 T15199 poss our,finding
R11282 T15199 T15197 pobj finding,with
R11283 T15200 T15202 punct ",",reported
R11284 T15201 T15202 nsubj others,reported
R11285 T15202 T15202 ROOT reported,reported
R11286 T15203 T15204 nsubj NF-κB,regulated
R11287 T15204 T15202 ccomp regulated,reported
R11288 T15205 T15207 det the,expression
R11289 T15206 T15207 compound gene,expression
R11290 T15207 T15204 dobj expression,regulated
R11291 T15208 T15207 prep of,expression
R11292 T15209 T15211 amod many,proteins
R11293 T15210 T15211 amod anti-apoptotic,proteins
R11294 T15211 T15208 pobj proteins,of
R11295 T15212 T15211 prep including,proteins
R11296 T15213 T15216 amod other,members
R11297 T15214 T15216 compound BCL-2,members
R11298 T15215 T15216 compound family,members
R11299 T15216 T15212 pobj members,including
R11300 T15217 T15216 cc and,members
R11301 T15218 T15216 conj inhibitor,members
R11302 T15219 T15218 prep of,inhibitor
R11303 T15220 T15224 amod apoptosis,proteins
R11304 T15221 T15222 punct (,IAP
R11305 T15222 T15220 appos IAP,apoptosis
R11306 T15223 T15222 punct ),IAP
R11307 T15224 T15219 pobj proteins,of
R11308 T15225 T15226 nsubj which,are
R11309 T15226 T15224 relcl are,proteins
R11310 T15227 T15226 attr regulators,are
R11311 T15228 T15227 prep of,regulators
R11312 T15229 T15228 pobj apoptosis,of
R11313 T15230 T15229 cc and,apoptosis
R11314 T15231 T15232 compound function,upstream
R11315 T15232 T15229 conj upstream,apoptosis
R11316 T15233 T15232 prep of,upstream
R11317 T15234 T15235 compound caspases,[
R11318 T15235 T15237 nmod [,]
R11319 T15236 T15237 nummod 44,]
R11320 T15237 T15233 pobj ],of
R11321 T15238 T15202 punct .,reported
R11322 T15239 T15242 nsubjpass It,shown
R11323 T15240 T15242 aux has,shown
R11324 T15241 T15242 auxpass been,shown
R11325 T15242 T15242 ROOT shown,shown
R11326 T15243 T15249 mark that,prevents
R11327 T15244 T15249 nsubj phosphorylation,prevents
R11328 T15245 T15244 prep of,phosphorylation
R11329 T15246 T15245 pobj p65,of
R11330 T15247 T15244 prep at,phosphorylation
R11331 T15248 T15247 pobj Ser276,at
R11332 T15249 T15242 ccomp prevents,shown
R11333 T15250 T15251 poss its,degradation
R11334 T15251 T15249 dobj degradation,prevents
R11335 T15252 T15251 prep by,degradation
R11336 T15253 T15254 amod ubiquitin-mediated,proteolysis
R11337 T15254 T15252 pobj proteolysis,by
R11338 T15255 T15249 cc and,prevents
R11339 T15256 T15249 conj promotes,prevents
R11340 T15257 T15258 compound cell,survival
R11341 T15258 T15256 dobj survival,promotes
R11342 T15259 T15256 prep in,promotes
R11343 T15260 T15261 compound HeLa,cells
R11344 T15261 T15259 pobj cells,in
R11345 T15262 T15264 nmod [,]
R11346 T15263 T15264 nummod 24,]
R11347 T15264 T15261 appos ],cells
R11348 T15265 T15242 punct .,shown
R11349 T15266 T15279 prep In,evaluating
R11350 T15267 T15266 pobj addition,In
R11351 T15268 T15267 prep to,addition
R11352 T15269 T15270 amod BCL-xL,expression
R11353 T15270 T15268 pobj expression,to
R11354 T15271 T15272 mark as,examined
R11355 T15272 T15279 advcl examined,evaluating
R11356 T15273 T15272 prep in,examined
R11357 T15274 T15275 det this,study
R11358 T15275 T15273 pobj study,in
R11359 T15276 T15279 punct ",",evaluating
R11360 T15277 T15279 nsubj we,evaluating
R11361 T15278 T15279 aux are,evaluating
R11362 T15279 T15279 ROOT evaluating,evaluating
R11363 T15280 T15281 det the,possibility
R11364 T15281 T15279 dobj possibility,evaluating
R11365 T15282 T15286 mark that,upregulates
R11366 T15283 T15285 amod PKCα-regulated,activity
R11367 T15284 T15285 compound NF-κB,activity
R11368 T15285 T15286 nsubj activity,upregulates
R11369 T15286 T15281 acl upregulates,possibility
R11370 T15287 T15289 amod additional,genes
R11371 T15288 T15289 amod anti-apoptotic,genes
R11372 T15289 T15286 dobj genes,upregulates
R11373 T15290 T15289 prep in,genes
R11374 T15291 T15293 det an,fashion
R11375 T15292 T15293 amod M-CSF-dependent,fashion
R11376 T15293 T15290 pobj fashion,in
R11377 T15294 T15295 aux to,modulate
R11378 T15295 T15289 relcl modulate,genes
R11379 T15296 T15297 compound cell,survival
R11380 T15297 T15295 dobj survival,modulate
R11381 T15298 T15279 punct .,evaluating
R11382 T15299 T15300 det The,use
R11383 T15300 T15310 nsubj use,ruled
R11384 T15301 T15300 prep of,use
R11385 T15302 T15301 pobj inhibitors,of
R11386 T15303 T15302 cc and,inhibitors
R11387 T15304 T15302 conj siRNA,inhibitors
R11388 T15305 T15302 prep in,inhibitors
R11389 T15306 T15307 poss our,study
R11390 T15307 T15305 pobj study,in
R11391 T15308 T15310 aux has,ruled
R11392 T15309 T15310 neg not,ruled
R11393 T15310 T15310 ROOT ruled,ruled
R11394 T15311 T15310 prt out,ruled
R11395 T15312 T15318 mark that,be
R11396 T15313 T15315 amod other,PKCs
R11397 T15314 T15315 amod conventional,PKCs
R11398 T15315 T15318 nsubj PKCs,be
R11399 T15316 T15318 aux might,be
R11400 T15317 T15318 advmod also,be
R11401 T15318 T15310 ccomp be,ruled
R11402 T15319 T15318 acomp important,be
R11403 T15320 T15318 prep in,be
R11404 T15321 T15323 amod M-CSF-induced,activation
R11405 T15322 T15323 compound NF-κB,activation
R11406 T15323 T15320 pobj activation,in
R11407 T15324 T15323 cc and,activation
R11408 T15325 T15326 compound macrophage,survival
R11409 T15326 T15323 conj survival,activation
R11410 T15327 T15310 punct .,ruled
R11411 T15328 T15347 prep In,appear
R11412 T15329 T15328 pobj contrast,In
R11413 T15330 T15329 prep to,contrast
R11414 T15331 T15332 det the,actions
R11415 T15332 T15330 pobj actions,to
R11416 T15333 T15332 prep of,actions
R11417 T15334 T15335 compound PKCα,activation
R11418 T15335 T15333 pobj activation,of
R11419 T15336 T15335 prep of,activation
R11420 T15337 T15340 amod other,isoforms
R11421 T15338 T15340 amod conventional,isoforms
R11422 T15339 T15340 compound PKC,isoforms
R11423 T15340 T15336 pobj isoforms,of
R11424 T15341 T15340 punct ",",isoforms
R11425 T15342 T15335 prep like,activation
R11426 T15343 T15345 compound PKCβI,βII
R11427 T15344 T15345 compound /,βII
R11428 T15345 T15342 pobj βII,like
R11429 T15346 T15347 punct ",",appear
R11430 T15347 T15347 ROOT appear,appear
R11431 T15348 T15347 oprd necessary,appear
R11432 T15349 T15348 prep for,necessary
R11433 T15350 T15351 amod macrophage,apoptosis
R11434 T15351 T15349 pobj apoptosis,for
R11435 T15352 T15347 punct .,appear
R11436 T15353 T15357 det The,isoforms
R11437 T15354 T15356 compound PKCβI,βII
R11438 T15355 T15356 compound /,βII
R11439 T15356 T15357 compound βII,isoforms
R11440 T15357 T15359 nsubjpass isoforms,expressed
R11441 T15358 T15359 auxpass are,expressed
R11442 T15359 T15359 ROOT expressed,expressed
R11443 T15360 T15359 prep in,expressed
R11444 T15361 T15364 amod apoptotic,cells
R11445 T15362 T15364 nmod U937,cells
R11446 T15363 T15364 amod myelomonocytic,cells
R11447 T15364 T15360 pobj cells,in
R11448 T15365 T15367 nmod [,]
R11449 T15366 T15367 nummod 45,]
R11450 T15367 T15359 npadvmod ],expressed
R11451 T15368 T15359 punct .,expressed
R11452 T15369 T15374 det The,HL-525
R11453 T15370 T15372 amod human,cell
R11454 T15371 T15372 compound myeloid,cell
R11455 T15372 T15373 compound cell,line
R11456 T15373 T15374 compound line,HL-525
R11457 T15374 T15381 nsubj HL-525,is
R11458 T15375 T15376 nsubj which,is
R11459 T15376 T15374 relcl is,HL-525
R11460 T15377 T15376 acomp devoid,is
R11461 T15378 T15377 prep of,devoid
R11462 T15379 T15380 compound endogenous,PKCβII
R11463 T15380 T15378 pobj PKCβII,of
R11464 T15381 T15381 ROOT is,is
R11465 T15382 T15381 acomp resistant,is
R11466 T15383 T15382 prep to,resistant
R11467 T15384 T15385 amod TNFα-induced,apoptosis
R11468 T15385 T15383 pobj apoptosis,to
R11469 T15386 T15383 pobj [,to
R11470 T15387 T15388 nummod 46,]
R11471 T15388 T15386 dobj ],[
R11472 T15389 T15381 punct .,is
R11473 T15390 T15396 nsubj Re-expression,restores
R11474 T15391 T15390 prep of,Re-expression
R11475 T15392 T15391 pobj PKCβII,of
R11476 T15393 T15392 prep in,PKCβII
R11477 T15394 T15395 compound HL-525,cells
R11478 T15395 T15393 pobj cells,in
R11479 T15396 T15396 ROOT restores,restores
R11480 T15397 T15398 poss their,susceptibility
R11481 T15398 T15396 dobj susceptibility,restores
R11482 T15399 T15400 aux to,TNFα-induced
R11483 T15400 T15396 xcomp TNFα-induced,restores
R11484 T15401 T15400 dobj apoptosis,TNFα-induced
R11485 T15402 T15400 advcl implying,TNFα-induced
R11486 T15403 T15405 mark that,is
R11487 T15404 T15405 nsubj PKCβII,is
R11488 T15405 T15402 ccomp is,implying
R11489 T15406 T15405 acomp pro-apoptotic,is
R11490 T15407 T15405 cc and,is
R11491 T15408 T15410 aux may,required
R11492 T15409 T15410 auxpass be,required
R11493 T15410 T15405 conj required,is
R11494 T15411 T15412 aux to,induce
R11495 T15412 T15410 advcl induce,required
R11496 T15413 T15414 compound macrophage,apoptosis
R11497 T15414 T15412 dobj apoptosis,induce
R11498 T15415 T15396 punct .,restores
R11499 T15416 T15417 amod Recent,studies
R11500 T15417 T15418 nsubj studies,demonstrated
R11501 T15418 T15418 ROOT demonstrated,demonstrated
R11502 T15419 T15425 mark that,regulated
R11503 T15420 T15422 amod NF-κB,activity
R11504 T15421 T15422 amod transcriptional,activity
R11505 T15422 T15425 nsubjpass activity,regulated
R11506 T15423 T15425 aux can,regulated
R11507 T15424 T15425 auxpass be,regulated
R11508 T15425 T15418 ccomp regulated,demonstrated
R11509 T15426 T15425 agent by,regulated
R11510 T15427 T15426 pobj phosphorylation,by
R11511 T15428 T15427 prep of,phosphorylation
R11512 T15429 T15432 det the,subunit
R11513 T15430 T15432 nmod NF-κB,subunit
R11514 T15431 T15432 nummod p65,subunit
R11515 T15432 T15428 pobj subunit,of
R11516 T15433 T15425 prep in,regulated
R11517 T15434 T15435 det the,absence
R11518 T15435 T15433 pobj absence,in
R11519 T15436 T15435 prep of,absence
R11520 T15437 T15438 compound IκBα,degradation
R11521 T15438 T15436 pobj degradation,of
R11522 T15439 T15441 nmod [,]
R11523 T15440 T15441 nummod 47,]
R11524 T15441 T15438 appos ],degradation
R11525 T15442 T15418 punct .,demonstrated
R11526 T15443 T15450 prep By,regulates
R11527 T15444 T15445 det this,pathway
R11528 T15445 T15443 pobj pathway,By
R11529 T15446 T15450 punct ",",regulates
R11530 T15447 T15450 nsubj phosphorylation,regulates
R11531 T15448 T15447 prep of,phosphorylation
R11532 T15449 T15448 pobj NF-κB,of
R11533 T15450 T15450 ROOT regulates,regulates
R11534 T15451 T15452 poss its,interaction
R11535 T15452 T15450 dobj interaction,regulates
R11536 T15453 T15452 prep with,interaction
R11537 T15454 T15455 amod other,components
R11538 T15455 T15453 pobj components,with
R11539 T15456 T15455 prep of,components
R11540 T15457 T15460 det the,machinery
R11541 T15458 T15460 amod basal,machinery
R11542 T15459 T15460 amod transcriptional,machinery
R11543 T15460 T15456 pobj machinery,of
R11544 T15461 T15450 prep without,regulates
R11545 T15462 T15461 pcomp affecting,without
R11546 T15463 T15464 poss its,capability
R11547 T15464 T15462 dobj capability,affecting
R11548 T15465 T15466 aux to,bind
R11549 T15466 T15462 xcomp bind,affecting
R11550 T15467 T15468 compound DNA,[
R11551 T15468 T15466 dobj [,bind
R11552 T15469 T15470 nummod 21,]
R11553 T15470 T15466 dobj ],bind
R11554 T15471 T15450 punct .,regulates
R11555 T15472 T15475 mark Since,bind
R11556 T15473 T15475 nsubj NF-κB,bind
R11557 T15474 T15475 aux can,bind
R11558 T15475 T15489 advcl bind,affect
R11559 T15476 T15477 det the,promoters
R11560 T15477 T15475 dobj promoters,bind
R11561 T15478 T15477 prep of,promoters
R11562 T15479 T15481 amod numerous,targets
R11563 T15480 T15481 compound gene,targets
R11564 T15481 T15478 pobj targets,of
R11565 T15482 T15481 punct ",",targets
R11566 T15483 T15484 amod post-translational,modification
R11567 T15484 T15477 conj modification,promoters
R11568 T15485 T15484 prep of,modification
R11569 T15486 T15487 compound NF-κB,p65
R11570 T15487 T15485 pobj p65,of
R11571 T15488 T15489 aux may,affect
R11572 T15489 T15489 ROOT affect,affect
R11573 T15490 T15491 poss its,interaction
R11574 T15491 T15489 dobj interaction,affect
R11575 T15492 T15491 prep with,interaction
R11576 T15493 T15494 amod other,proteins
R11577 T15494 T15492 pobj proteins,with
R11578 T15495 T15489 punct ",",affect
R11579 T15496 T15489 advcl refining,affect
R11580 T15497 T15498 det the,expression
R11581 T15498 T15496 dobj expression,refining
R11582 T15499 T15498 prep of,expression
R11583 T15500 T15501 compound gene,targets
R11584 T15501 T15499 pobj targets,of
R11585 T15502 T15489 punct .,affect
R11586 T15503 T15506 nsubj We,find
R11587 T15504 T15506 aux did,find
R11588 T15505 T15506 neg not,find
R11589 T15506 T15506 ROOT find,find
R11590 T15507 T15510 mark that,involved
R11591 T15508 T15510 nsubjpass PKC,involved
R11592 T15509 T15510 auxpass was,involved
R11593 T15510 T15506 ccomp involved,find
R11594 T15511 T15510 prep in,involved
R11595 T15512 T15513 compound IκBα,degradation
R11596 T15513 T15511 pobj degradation,in
R11597 T15514 T15513 cc or,degradation
R11598 T15515 T15516 compound NF-κB,p65
R11599 T15516 T15518 nummod p65,translocation
R11600 T15517 T15518 amod nuclear,translocation
R11601 T15518 T15513 conj translocation,degradation
R11602 T15519 T15513 acl induced,degradation
R11603 T15520 T15519 agent by,induced
R11604 T15521 T15520 pobj M-CSF,by
R11605 T15522 T15506 punct ",",find
R11606 T15523 T15506 cc but,find
R11607 T15524 T15526 det that,phosphorylation
R11608 T15525 T15526 amod M-CSF-induced,phosphorylation
R11609 T15526 T15534 nsubjpass phosphorylation,reduced
R11610 T15527 T15526 prep of,phosphorylation
R11611 T15528 T15529 compound NF-κB,p65
R11612 T15529 T15527 pobj p65,of
R11613 T15530 T15526 prep at,phosphorylation
R11614 T15531 T15530 pobj Ser276,at
R11615 T15532 T15534 auxpass was,reduced
R11616 T15533 T15534 advmod dramatically,reduced
R11617 T15534 T15506 conj reduced,find
R11618 T15535 T15534 agent by,reduced
R11619 T15536 T15539 det the,inhibitor
R11620 T15537 T15539 amod conventional,inhibitor
R11621 T15538 T15539 compound PKC,inhibitor
R11622 T15539 T15535 pobj inhibitor,by
R11623 T15540 T15539 cc and,inhibitor
R11624 T15541 T15539 conj kinase,inhibitor
R11625 T15542 T15534 advcl deficient,reduced
R11626 T15543 T15542 dobj PKCα,deficient
R11627 T15544 T15542 cc and,deficient
R11628 T15545 T15534 agent by,reduced
R11629 T15546 T15545 pobj siRNA,by
R11630 T15547 T15534 prep towards,reduced
R11631 T15548 T15547 pobj PKCα,towards
R11632 T15549 T15534 punct .,reduced
R11633 T15550 T15551 amod Current,studies
R11634 T15551 T15552 nsubj studies,are
R11635 T15552 T15552 ROOT are,are
R11636 T15553 T15552 acomp underway,are
R11637 T15554 T15555 aux to,delineate
R11638 T15555 T15553 xcomp delineate,underway
R11639 T15556 T15558 det the,complexes
R11640 T15557 T15558 compound protein,complexes
R11641 T15558 T15555 dobj complexes,delineate
R11642 T15559 T15558 acl formed,complexes
R11643 T15560 T15559 agent by,formed
R11644 T15561 T15562 amod activated,NF-κB
R11645 T15562 T15560 pobj NF-κB,by
R11646 T15563 T15562 cc and,NF-κB
R11647 T15564 T15566 amod other,co-activators
R11648 T15565 T15566 amod transcriptional,co-activators
R11649 T15566 T15562 conj co-activators,NF-κB
R11650 T15567 T15559 prep in,formed
R11651 T15568 T15567 pobj response,in
R11652 T15569 T15568 prep to,response
R11653 T15570 T15569 pobj M-CSF,to
R11654 T15571 T15570 cc and,M-CSF
R11655 T15572 T15573 compound PKC,activation
R11656 T15573 T15570 conj activation,M-CSF
R11657 T15574 T15552 punct .,are
R11658 T15575 T15577 advmod Recently,indicated
R11659 T15576 T15577 nsubj studies,indicated
R11660 T15577 T15577 ROOT indicated,indicated
R11661 T15578 T15583 mark that,activated
R11662 T15579 T15581 det the,pathway
R11663 T15580 T15581 amod non-canonical,pathway
R11664 T15581 T15583 nsubjpass pathway,activated
R11665 T15582 T15583 auxpass was,activated
R11666 T15583 T15577 ccomp activated,indicated
R11667 T15584 T15583 prep during,activated
R11668 T15585 T15586 amod human,monocyte-macrophage
R11669 T15586 T15587 compound monocyte-macrophage,differentiation
R11670 T15587 T15588 compound differentiation,[
R11671 T15588 T15590 compound [,]
R11672 T15589 T15590 nummod 48,]
R11673 T15590 T15584 pobj ],during
R11674 T15591 T15577 punct .,indicated
R11675 T15592 T15603 prep During,is
R11676 T15593 T15594 det this,process
R11677 T15594 T15592 pobj process,During
R11678 T15595 T15596 punct ",",expression
R11679 T15596 T15603 nsubj expression,is
R11680 T15597 T15596 prep of,expression
R11681 T15598 T15597 pobj IKKα,of
R11682 T15599 T15596 prep among,expression
R11683 T15600 T15601 amod other,proteins
R11684 T15601 T15599 pobj proteins,among
R11685 T15602 T15603 punct ",",is
R11686 T15603 T15603 ROOT is,is
R11687 T15604 T15603 acomp elevated,is
R11688 T15605 T15603 advcl leading,is
R11689 T15606 T15605 prep to,leading
R11690 T15607 T15609 amod increased,NF-κB
R11691 T15608 T15609 nummod p52,NF-κB
R11692 T15609 T15606 pobj NF-κB,to
R11693 T15610 T15609 punct (,NF-κB
R11694 T15611 T15609 appos relB,NF-κB
R11695 T15612 T15609 punct ),NF-κB
R11696 T15613 T15605 dobj expression,leading
R11697 T15614 T15605 prep through,leading
R11698 T15615 T15617 amod partial,degradation
R11699 T15616 T15617 amod proteolytic,degradation
R11700 T15617 T15614 pobj degradation,through
R11701 T15618 T15617 prep of,degradation
R11702 T15619 T15622 det the,protein
R11703 T15620 T15622 nummod p100,protein
R11704 T15621 T15622 compound NF-κB,protein
R11705 T15622 T15618 pobj protein,of
R11706 T15623 T15603 punct .,is
R11707 T15624 T15627 advmod Thus,is
R11708 T15625 T15627 punct ",",is
R11709 T15626 T15627 nsubj it,is
R11710 T15627 T15627 ROOT is,is
R11711 T15628 T15627 acomp possible,is
R11712 T15629 T15631 mark that,regulates
R11713 T15630 T15631 nsubj M-CSF,regulates
R11714 T15631 T15627 ccomp regulates,is
R11715 T15632 T15633 compound monocyte,survival
R11716 T15633 T15631 dobj survival,regulates
R11717 T15634 T15631 prep through,regulates
R11718 T15635 T15641 predet both,pathways
R11719 T15636 T15641 det the,pathways
R11720 T15637 T15641 amod canonical,pathways
R11721 T15638 T15637 cc and,canonical
R11722 T15639 T15637 conj non-canonical,canonical
R11723 T15640 T15641 compound NF-κB,pathways
R11724 T15641 T15634 pobj pathways,through
R11725 T15642 T15641 punct ",",pathways
R11726 T15643 T15645 nsubj which,be
R11727 T15644 T15645 aux will,be
R11728 T15645 T15641 relcl be,pathways
R11729 T15646 T15647 det a,focus
R11730 T15647 T15645 attr focus,be
R11731 T15648 T15647 prep in,focus
R11732 T15649 T15650 amod future,research
R11733 T15650 T15648 pobj research,in
R11734 T15651 T15627 punct .,is
R11735 T15652 T15654 nsubj We,showed
R11736 T15653 T15654 advmod previously,showed
R11737 T15654 T15654 ROOT showed,showed
R11738 T15655 T15657 mark that,reduced
R11739 T15656 T15657 nsubj M-CSF,reduced
R11740 T15657 T15654 ccomp reduced,showed
R11741 T15658 T15661 amod caspase-3,activity
R11742 T15659 T15658 cc and,caspase-3
R11743 T15660 T15658 conj -9,caspase-3
R11744 T15661 T15657 dobj activity,reduced
R11745 T15662 T15657 cc and,reduced
R11746 T15663 T15657 conj prevented,reduced
R11747 T15664 T15665 compound monocyte,apoptosis
R11748 T15665 T15666 compound apoptosis,[
R11749 T15666 T15666 ROOT [,[
R11750 T15667 T15668 nummod 3,]
R11751 T15668 T15663 dobj ],prevented
R11752 T15669 T15654 punct .,showed
R11753 T15670 T15671 det This,study
R11754 T15671 T15672 nsubj study,reveals
R11755 T15672 T15672 ROOT reveals,reveals
R11756 T15673 T15687 mark that,blocked
R11757 T15674 T15687 nsubj treatment,blocked
R11758 T15675 T15674 prep of,treatment
R11759 T15676 T15675 pobj monocytes,of
R11760 T15677 T15676 prep with,monocytes
R11761 T15678 T15680 amod conventional,inhibitors
R11762 T15679 T15680 compound PKC,inhibitors
R11763 T15680 T15677 pobj inhibitors,with
R11764 T15681 T15680 punct ",",inhibitors
R11765 T15682 T15676 cc or,monocytes
R11766 T15683 T15676 conj overexpression,monocytes
R11767 T15684 T15683 prep of,overexpression
R11768 T15685 T15686 compound kinase-deficient,PKCα
R11769 T15686 T15684 pobj PKCα,of
R11770 T15687 T15672 ccomp blocked,reveals
R11771 T15688 T15690 amod M-CSF-induced,survival
R11772 T15689 T15690 compound cell,survival
R11773 T15690 T15687 dobj survival,blocked
R11774 T15691 T15672 punct .,reveals
R11775 T15692 T15693 poss Our,data
R11776 T15693 T15694 nsubj data,revealed
R11777 T15694 T15694 ROOT revealed,revealed
R11778 T15695 T15698 mark that,are
R11779 T15696 T15697 amod conventional,PKCs
R11780 T15697 T15698 nsubj PKCs,are
R11781 T15698 T15694 ccomp are,revealed
R11782 T15699 T15698 attr upstream,are
R11783 T15700 T15699 prep of,upstream
R11784 T15701 T15702 amod NF-κB,activation
R11785 T15702 T15700 pobj activation,of
R11786 T15703 T15698 prep in,are
R11787 T15704 T15703 pobj response,in
R11788 T15705 T15704 prep to,response
R11789 T15706 T15705 pobj M-CSF,to
R11790 T15707 T15698 cc and,are
R11791 T15708 T15698 conj mediate,are
R11792 T15709 T15710 amod post-translational,activation
R11793 T15710 T15708 dobj activation,mediate
R11794 T15711 T15710 prep of,activation
R11795 T15712 T15711 pobj NF-κB,of
R11796 T15713 T15712 nummod p65,NF-κB
R11797 T15714 T15708 prep by,mediate
R11798 T15715 T15714 pcomp phosphorylating,by
R11799 T15716 T15715 dobj Ser276,phosphorylating
R11800 T15717 T15718 aux to,regulate
R11801 T15718 T15715 advcl regulate,phosphorylating
R11802 T15719 T15720 compound gene,transcription
R11803 T15720 T15718 dobj transcription,regulate
R11804 T15721 T15720 cc and,transcription
R11805 T15722 T15723 compound cell,survival
R11806 T15723 T15720 conj survival,transcription
R11807 T15724 T15694 punct .,revealed
R11808 T15725 T15730 advmod Thus,provide
R11809 T15726 T15730 punct ",",provide
R11810 T15727 T15728 poss our,observation
R11811 T15728 T15730 nsubj observation,provide
R11812 T15729 T15730 aux may,provide
R11813 T15730 T15730 ROOT provide,provide
R11814 T15731 T15730 dobj insight,provide
R11815 T15732 T15730 prep in,provide
R11816 T15733 T15735 amod potential,targets
R11817 T15734 T15735 amod therapeutic,targets
R11818 T15735 T15732 pobj targets,in
R11819 T15736 T15735 prep for,targets
R11820 T15737 T15738 amod inflammatory,diseases
R11821 T15738 T15736 pobj diseases,for
R11822 T15739 T15730 punct .,provide
R20476 T26848 T26849 amod Proposed,model
R20477 T26849 T26849 ROOT model,model
R20478 T26850 T26849 prep for,model
R20479 T26851 T26853 amod M-CSF-induced,survival
R20480 T26852 T26853 compound monocyte,survival
R20481 T26853 T26850 pobj survival,for
R20482 T26854 T26849 prep via,model
R20483 T26855 T26856 compound PKC,regulation
R20484 T26856 T26854 pobj regulation,via
R20486 T26858 T26857 pcomp activating,by
R20487 T26859 T26861 nsubj NF-κB,phosphorylation
R20488 T26860 T26861 nummod p65,phosphorylation
R20489 T26861 T26858 dobj phosphorylation,activating
R20490 T26862 T26861 prep at,phosphorylation
R20491 T26863 T26862 pobj Ser276,at
R20492 T26864 T26849 punct .,model
R20485 T26857 T26849 prep by,model

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T14294 212-215 Protein denotes p50
T14295 216-219 Protein denotes p65
T14296 233-244 Localization denotes translocate
T14297 252-259 Entity denotes nucleus
T14298 289-294 Protein denotes their
T14299 295-308 Localization denotes translocation
T14300 703-708 Protein denotes M-CSF
T14301 853-858 Protein denotes M-CSF
T14302 870-874 Protein denotes PKCα
T14303 1029-1035 Negative_regulation denotes kinase
T14304 1036-1045 Negative_regulation denotes deficient true
T14305 1046-1050 Protein denotes PKCα
T14306 1054-1064 Protein denotes PKCα siRNA
T14307 1073-1078 Protein denotes M-CSF
T14308 1167-1176 Negative_regulation denotes reduction true
T14309 1180-1185 Protein denotes M-CSF
T14310 1186-1193 Positive_regulation denotes induced
T14311 1194-1209 Phosphorylation denotes phosphorylation
T14312 1219-1222 Protein denotes p65
T14313 1226-1232 Entity denotes Ser276
T14314 1269-1291 Protein denotes dominant negative PKCα
T14315 1308-1317 Negative_regulation denotes inhibited
T14316 1324-1327 Protein denotes p65
T14317 1328-1343 Phosphorylation denotes phosphorylation
T14318 1347-1353 Entity denotes Ser276
T14319 1365-1371 Entity denotes Ser536
T14320 1430-1435 Protein denotes M-CSF
T14321 1524-1529 Protein denotes M-CSF
T14322 1560-1569 Regulation denotes regulated
T14323 1573-1583 Positive_regulation denotes activating
T14324 1590-1593 Protein denotes p65
T14325 1594-1609 Phosphorylation denotes phosphorylation
T14326 1613-1619 Entity denotes Ser276
T14327 1649-1652 Protein denotes p65
T14328 1700-1706 Entity denotes Ser276
T14329 1724-1727 Protein denotes p65
T14330 2067-2098 Protein_modification denotes Post-translational modification
T14331 2108-2111 Protein denotes p65
T14332 2219-2222 Protein denotes p65
T14333 2223-2238 Phosphorylation denotes phosphorylation
T14334 2251-2259 Positive_regulation denotes increase
T14335 2260-2267 Entity denotes nuclear
T14336 2268-2281 Localization denotes translocation
T14337 2287-2294 Binding denotes binding
T14338 2410-2413 Protein denotes p65
T14339 2417-2431 Phosphorylation denotes phosphorylated
T14340 2456-2462 Entity denotes Ser276 true
T14341 2529-2535 Entity denotes Ser276
T14342 2543-2557 Phosphorylation denotes phosphorylated
T14343 2561-2565 Protein denotes MSK1
T14344 2573-2580 Entity denotes nucleus
T14345 2586-2590 Protein denotes TNFα
T14346 2607-2622 Phosphorylation denotes Phosphorylation true
T14347 2632-2635 Protein denotes p65
T14348 2639-2645 Entity denotes Ser536 true
T14349 2714-2718 Protein denotes IKKα
T14350 2720-2724 Protein denotes IKKβ true
T14351 2729-2733 Protein denotes RSK1
T14352 2804-2810 Entity denotes Ser276
T14353 2845-2850 Protein denotes M-CSF
T14354 2856-2865 Regulation denotes modulated
T14355 2870-2885 Phosphorylation denotes phosphorylation
T14356 2899-2902 Protein denotes p65
T14357 2914-2920 Entity denotes Ser536
T14358 2949-2955 Negative_regulation denotes kinase
T14359 2956-2965 Negative_regulation denotes deficient
T14360 2966-2970 Protein denotes PKCα
T14361 2990-2996 Regulation denotes affect
T14362 3002-3017 Phosphorylation denotes phosphorylation
T14363 3072-3080 Negative_regulation denotes mutation
T14364 3084-3090 Entity denotes Ser536
T14365 3100-3103 Protein denotes p65
T14366 3143-3150 Negative_regulation denotes lacking
T14367 3168-3171 Protein denotes p65
T14368 3189-3192 Protein denotes p65
T14369 3272-3303 Protein_modification denotes post-translational modification
T14370 3313-3316 Protein denotes p65
T14371 3429-3434 Protein denotes M-CSF
T14372 3435-3444 Positive_regulation denotes activated
T14373 3451-3454 Protein denotes p65
T14374 3455-3461 Entity denotes Ser276
T14375 3462-3477 Phosphorylation denotes phosphorylation
T14376 3498-3508 Positive_regulation denotes activation
T14377 3514-3518 Protein denotes PKCα
T14378 3519-3528 Regulation denotes dependent
T14379 3537-3541 Protein denotes PKCα
T14380 3671-3675 Protein denotes PKCα
T14381 3794-3804 Gene_expression denotes Expression
T14382 3808-3812 Protein denotes PKCα
T14383 3870-3874 Protein denotes PKCα
T14384 3875-3885 Negative_regulation denotes inhibition
T14385 3977-3999 Protein denotes dominant negative PKCα
T14386 4012-4016 Protein denotes PKCα
T14387 4033-4038 Protein denotes M-CSF
T14388 4070-4078 Negative_regulation denotes inducing
T14389 4079-4085 Entity denotes Ser276
T14390 4086-4101 Phosphorylation denotes phosphorylation
T14391 4111-4114 Protein denotes p65
T14392 4199-4212 Negative_regulation denotes downregulated
T14393 4256-4262 Protein denotes BCL-xL
T14394 4553-4568 Phosphorylation denotes phosphorylation
T14395 4572-4575 Protein denotes p65
T14396 4579-4585 Entity denotes Ser276
T14397 4599-4610 Protein_catabolism denotes degradation
T14398 4614-4623 Protein denotes ubiquitin
T14399 4707-4713 Protein denotes BCL-xL
T14400 4714-4724 Gene_expression denotes expression
T14401 4791-4795 Protein denotes PKCα
T14402 4871-4876 Protein denotes M-CSF
T14403 5041-5046 Protein denotes M-CSF
T14404 5127-5131 Protein denotes PKCα
T14405 5132-5142 Positive_regulation denotes activation
T14406 5184-5189 Protein denotes PKCβI
T14407 5190-5193 Protein denotes βII
T14408 5242-5247 Protein denotes PKCβI
T14409 5248-5251 Protein denotes βII
T14410 5265-5274 Gene_expression denotes expressed
T14411 5385-5391 Protein denotes PKCβII
T14412 5408-5412 Protein denotes TNFα
T14413 5437-5439 Positive_regulation denotes Re
T14414 5439-5440 Gene_expression denotes -
T14415 5440-5450 Gene_expression denotes expression
T14416 5454-5460 Protein denotes PKCβII
T14417 5510-5514 Protein denotes TNFα
T14418 5547-5553 Protein denotes PKCβII
T14419 5694-5703 Regulation denotes regulated
T14420 5707-5722 Phosphorylation denotes phosphorylation
T14421 5736-5739 Protein denotes p65
T14422 5755-5762 Negative_regulation denotes absence
T14423 5766-5770 Protein denotes IκBα
T14424 5771-5782 Protein_catabolism denotes degradation
T14425 5845-5856 Binding denotes interaction
T14426 5985-5989 Binding denotes bind
T14427 6030-6061 Protein_modification denotes post-translational modification
T14428 6071-6074 Protein denotes p65
T14429 6079-6085 Regulation denotes affect
T14430 6090-6101 Binding denotes interaction
T14431 6193-6201 Regulation denotes involved
T14432 6205-6209 Protein denotes IκBα
T14433 6210-6221 Protein_catabolism denotes degradation
T14434 6231-6234 Protein denotes p65
T14435 6235-6242 Entity denotes nuclear
T14436 6243-6256 Localization denotes translocation
T14437 6257-6264 Positive_regulation denotes induced
T14438 6268-6273 Protein denotes M-CSF
T14439 6284-6289 Protein denotes M-CSF
T14440 6290-6297 Positive_regulation denotes induced
T14441 6298-6313 Phosphorylation denotes phosphorylation
T14442 6323-6326 Protein denotes p65
T14443 6330-6336 Entity denotes Ser276
T14444 6354-6361 Negative_regulation denotes reduced
T14445 6400-6406 Negative_regulation denotes kinase
T14446 6407-6416 Negative_regulation denotes deficient
T14447 6417-6421 Protein denotes PKCα
T14448 6429-6434 Protein denotes siRNA
T14449 6443-6447 Protein denotes PKCα
T14450 6594-6599 Protein denotes M-CSF
T14451 6768-6778 Gene_expression denotes expression
T14452 6782-6786 Protein denotes IKKα
T14453 6812-6820 Positive_regulation denotes elevated
T14454 6832-6841 Positive_regulation denotes increased
T14455 6842-6845 Protein denotes p52
T14456 6853-6857 Protein denotes relB
T14457 6859-6869 Gene_expression denotes expression
T14458 6898-6909 Protein_catabolism denotes degradation
T14459 6917-6921 Protein denotes p100
T14460 6963-6968 Protein denotes M-CSF
T14461 7126-7131 Protein denotes M-CSF
T14462 7140-7149 Protein denotes caspase-3
T14463 7154-7156 Protein denotes -9
T14464 7313-7322 Negative_regulation denotes deficient
T14465 7323-7327 Protein denotes PKCα
T14466 7336-7341 Protein denotes M-CSF
T14467 7454-7459 Protein denotes M-CSF
T14468 7464-7471 Positive_regulation denotes mediate
T14469 7472-7490 Protein_modification denotes post-translational
T14470 7491-7501 Positive_regulation denotes activation
T14471 7511-7514 Protein denotes p65
T14472 7518-7533 Phosphorylation denotes phosphorylating
T14473 7534-7540 Entity denotes Ser276
T26841 1963-1968 Protein denotes M-CSF
T26842 2003-2013 Regulation denotes regulation
T26843 2017-2027 Positive_regulation denotes activating
T26844 2034-2037 Protein denotes p65
T26845 2038-2053 Phosphorylation denotes phosphorylation
T26846 2057-2063 Entity denotes Ser276
R10505 T14294 T14296 themeOf p50,translocate
R10506 T14295 T14296 themeOf p65,translocate
R10507 T14297 T14296 locationOf nucleus,translocate
R10508 T14298 T14299 themeOf their,translocation
R10509 T14309 T14310 causeOf M-CSF,induced
R10510 T14310 T14308 themeOf induced,reduction
R10511 T14311 T14310 themeOf phosphorylation,induced
R10512 T14313 T14311 themeOf Ser276,phosphorylation
R10513 T14313 T14312 partOf Ser276,p65
R10514 T14314 T14315 causeOf dominant negative PKCα,inhibited
R10515 T14317 T14315 themeOf phosphorylation,inhibited
R10516 T14318 T14316 partOf Ser276,p65
R10517 T14318 T14317 themeOf Ser276,phosphorylation
R10518 T14319 T14316 partOf Ser536,p65
R10519 T14319 T14317 themeOf Ser536,phosphorylation
R10520 T14321 T14323 causeOf M-CSF,activating
R10521 T14325 T14323 themeOf phosphorylation,activating
R10522 T14326 T14325 themeOf Ser276,phosphorylation
R10523 T14326 T14324 partOf Ser276,p65
R10524 T14328 T14329 partOf Ser276,p65
R10525 T14331 T14330 themeOf p65,Post-translational modification
R10526 T14332 T14336 themeOf p65,translocation
R10527 T14332 T14337 themeOf p65,binding
R10528 T14335 T14336 locationOf nuclear,translocation
R10529 T14336 T14334 themeOf translocation,increase
R10530 T14337 T14334 themeOf binding,increase
R10531 T14340 T14339 themeOf Ser276,phosphorylated
R10532 T14340 T14338 partOf Ser276,p65
R10533 T14341 T14342 themeOf Ser276,phosphorylated
R10534 T14343 T14342 causeOf MSK1,phosphorylated
R10535 T14348 T14346 themeOf Ser536,Phosphorylation
R10536 T14348 T14347 partOf Ser536,p65
R10537 T14353 T14354 causeOf M-CSF,modulated
R10538 T14355 T14354 themeOf phosphorylation,modulated
R10539 T14357 T14356 partOf Ser536,p65
R10540 T14357 T14355 themeOf Ser536,phosphorylation
R10541 T14362 T14361 themeOf phosphorylation,affect
R10542 T14364 T14363 themeOf Ser536,mutation
R10543 T14364 T14365 partOf Ser536,p65
R10544 T14367 T14366 themeOf p65,lacking
R10545 T14370 T14369 themeOf p65,post-translational modification
R10546 T14371 T14372 causeOf M-CSF,activated
R10547 T14374 T14373 partOf Ser276,p65
R10548 T14374 T14375 themeOf Ser276,phosphorylation
R10549 T14375 T14372 themeOf phosphorylation,activated
R10550 T14376 T14372 themeOf activation,activated
R10551 T14382 T14381 themeOf PKCα,Expression
R10552 T14383 T14384 themeOf PKCα,inhibition
R10553 T14389 T14391 partOf Ser276,p65
R10554 T14389 T14390 themeOf Ser276,phosphorylation
R10555 T14390 T14388 themeOf phosphorylation,inducing
R10556 T14395 T14397 themeOf p65,degradation
R10557 T14396 T14394 themeOf Ser276,phosphorylation
R10558 T14396 T14395 partOf Ser276,p65
R10559 T14399 T14400 themeOf BCL-xL,expression
R10560 T14404 T14405 themeOf PKCα,activation
R10561 T14408 T14410 themeOf PKCβI,expressed
R10562 T14409 T14410 themeOf βII,expressed
R10563 T14416 T14415 themeOf PKCβII,expression
R10564 T14421 T14420 themeOf p65,phosphorylation
R10565 T14423 T14424 themeOf IκBα,degradation
R10566 T14424 T14422 themeOf degradation,absence
R10567 T14427 T14429 causeOf post-translational modification,affect
R10568 T14428 T14430 themeOf p65,interaction
R10569 T14428 T14427 themeOf p65,post-translational modification
R10570 T14430 T14429 themeOf interaction,affect
R10571 T14432 T14433 themeOf IκBα,degradation
R10572 T14433 T14431 themeOf degradation,involved
R10573 T14434 T14436 themeOf p65,translocation
R10574 T14435 T14436 locationOf nuclear,translocation
R10575 T14436 T14431 themeOf translocation,involved
R10576 T14436 T14437 themeOf translocation,induced
R10577 T14437 T14431 themeOf induced,involved
R10578 T14438 T14437 causeOf M-CSF,induced
R10579 T14439 T14440 causeOf M-CSF,induced
R10580 T14440 T14444 themeOf induced,reduced
R10581 T14441 T14440 themeOf phosphorylation,induced
R10582 T14443 T14442 partOf Ser276,p65
R10583 T14443 T14441 themeOf Ser276,phosphorylation
R10584 T14445 T14444 causeOf kinase,reduced
R10585 T14446 T14444 causeOf deficient,reduced
R10586 T14447 T14446 themeOf PKCα,deficient
R10587 T14447 T14444 causeOf PKCα,reduced
R10588 T14448 T14444 causeOf siRNA,reduced
R10589 T14449 T14448 themeOf PKCα,siRNA
R10590 T14449 T14444 causeOf PKCα,reduced
R10591 T14451 T14454 causeOf expression,increased
R10592 T14452 T14451 themeOf IKKα,expression
R10593 T14455 T14457 themeOf p52,expression
R10594 T14457 T14454 themeOf expression,increased
R10595 T14459 T14458 themeOf p100,degradation
R10596 T14465 T14464 themeOf PKCα,deficient
R10597 T14469 T14468 themeOf post-translational,mediate
R10598 T14470 T14468 themeOf activation,mediate
R10599 T14472 T14470 causeOf phosphorylating,activation
R10600 T14473 T14472 themeOf Ser276,phosphorylating
R10601 T14473 T14471 partOf Ser276,p65
R20473 T26845 T26843 themeOf phosphorylation,activating
R20474 T26846 T26844 partOf Ser276,p65
R20475 T26846 T26845 themeOf Ser276,phosphorylation