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PMC:3245220 / 23106-28077 JSONTXT

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bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T11285 18-22 P17252 denotes PKCα
T11286 139-143 P17252 denotes PKCα
T11287 202-207 P09603 denotes M-CSF
T11288 204-207 P04141 denotes CSF
T11289 242-246 P17252 denotes PKCα
T11290 286-291 P09603 denotes M-CSF
T11291 288-291 P04141 denotes CSF
T11292 326-330 P17252 denotes PKCα
T11293 403-407 P17252 denotes PKCα
T11294 433-437 P17252 denotes PKCα
T11295 592-596 P17252 denotes PKCα
T11296 661-666 P09603 denotes M-CSF
T11297 663-666 P04141 denotes CSF
T11298 724-729 P09603 denotes M-CSF
T11299 726-729 P04141 denotes CSF
T11300 816-820 P17252 denotes PKCα
T11301 853-858 P09603 denotes M-CSF
T11302 855-858 P04141 denotes CSF
T11303 897-901 P17252 denotes PKCα
T11304 980-984 P17252 denotes PKCα
T11305 1040-1045 P09603 denotes M-CSF
T11306 1042-1045 P04141 denotes CSF
T11307 1123-1127 P17252 denotes PKCα
T11308 1162-1166 P17252 denotes PKCα
T11309 1206-1211 P09603 denotes M-CSF
T11310 1208-1211 P04141 denotes CSF
T11311 1297-1301 P17252 denotes PKCα
T11312 3164-3168 P17252 denotes PKCα
T11313 3175-3179 P17252 denotes PKCα
T11314 3194-3203 P08758 denotes Annexin V
T11315 3239-3244 P09603 denotes M-CSF
T11316 3241-3244 P04141 denotes CSF
T11317 3298-3307 P08758 denotes Annexin V
T11318 3355-3359 P17252 denotes PKCα
T11319 3422-3426 P17252 denotes PKCα
T11320 3437-3442 P09603 denotes M-CSF
T11321 3439-3442 P04141 denotes CSF
T11322 3534-3538 P17252 denotes PKCα
T11323 3616-3620 P17252 denotes PKCα
T11324 3707-3710 P21579 denotes p65
T11325 3707-3710 Q04206 denotes p65
T11326 3775-3779 P17252 denotes PKCα
T11327 3849-3854 P09603 denotes M-CSF
T11328 3851-3854 P04141 denotes CSF
T11329 3904-3908 P17252 denotes PKCα
T11330 3925-3930 P09603 denotes M-CSF
T11331 3927-3930 P04141 denotes CSF
T11332 4040-4043 P21579 denotes p65
T11333 4040-4043 Q04206 denotes p65
T11334 4081-4085 P17252 denotes PKCα
T11335 4096-4101 P09603 denotes M-CSF
T11336 4098-4101 P04141 denotes CSF
T11337 4159-4163 P17252 denotes PKCα
T11338 4220-4224 P17252 denotes PKCα
T11339 4306-4311 P09603 denotes M-CSF
T11340 4308-4311 P04141 denotes CSF
T11341 4329-4333 P17252 denotes PKCα
T11342 4355-4360 P09603 denotes M-CSF
T11343 4357-4360 P04141 denotes CSF
T11344 4526-4535 P08758 denotes Annexin V
T11345 4563-4567 P17252 denotes PKCα
T11346 4611-4616 P09603 denotes M-CSF
T11347 4613-4616 P04141 denotes CSF
T11348 4680-4684 P17252 denotes PKCα
T11349 4787-4791 P17252 denotes PKCα
T11350 4821-4825 P17252 denotes PKCα
T11351 4905-4909 P17252 denotes PKCα
T11352 4941-4946 P09603 denotes M-CSF
T11353 4943-4946 P04141 denotes CSF
T26103 1347-1351 P17252 denotes PKCα
T26104 1387-1390 P21579 denotes p65
T26105 1387-1390 Q04206 denotes p65
T26106 1500-1504 P17252 denotes PKCα
T26107 1534-1538 P17252 denotes PKCα
T26108 1610-1615 P09603 denotes M-CSF
T26109 1612-1615 P04141 denotes CSF
T26110 1915-1924 P08758 denotes Annexin V
T26111 2101-2104 P21579 denotes p65
T26112 2101-2104 Q04206 denotes p65
T26113 2147-2151 P17252 denotes PKCα
T26114 2198-2202 P17252 denotes PKCα
T26115 2215-2222 P60709 denotes β-actin
T26116 2423-2427 P17252 denotes PKCα
T26117 2537-2542 P09603 denotes M-CSF
T26118 2539-2542 P04141 denotes CSF
T26119 2778-2787 P08758 denotes Annexin V
T26120 2973-2977 P17252 denotes PKCα
T26121 2988-2995 P60709 denotes β-actin

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation
T11354 146-156 Negative_regulation denotes inhibitors
T11355 1159-1161 Negative_regulation denotes KD
T11356 1277-1288 Gene_expression denotes transfected
T11357 3143-3153 Gene_expression denotes expressing
T11358 3172-3174 Negative_regulation denotes KD
T11359 3311-3319 Negative_regulation denotes negative
T11360 3338-3348 Gene_expression denotes expression
T11361 3419-3421 Negative_regulation denotes KD
T11362 3519-3529 Gene_expression denotes expressing
T11363 3613-3615 Negative_regulation denotes KD
T11364 3648-3654 Regulation denotes affect true
T11365 146-156 Negative_regulation denotes inhibitors
T11366 3672-3687 Phosphorylation denotes phosphorylation
T11367 3716-3726 Negative_regulation denotes attenuated
T11368 3731-3746 Phosphorylation denotes phosphorylation
T11369 3758-3768 Gene_expression denotes Expression
T11370 3788-3794 Regulation denotes effect true
T11371 3799-3814 Phosphorylation denotes phosphorylation
T11372 3788-3794 Regulation denotes effect true
T11373 3799-3814 Phosphorylation denotes phosphorylation
T11374 3833-3848 Regulation denotes with or without true
T11375 3833-3848 Regulation denotes with or without true
T11376 411-427 Negative_regulation denotes kinase-deficient
T11377 4005-4020 Phosphorylation denotes phosphorylation
T11378 4313-4321 Negative_regulation denotes Reducing
T11379 4334-4344 Gene_expression denotes expression
T11380 4811-4820 Negative_regulation denotes decreased
T11381 4834-4844 Gene_expression denotes expression
T11382 442-456 Gene_expression denotes co-transfected
T11383 553-567 Gene_expression denotes co-transfected
T11384 813-815 Negative_regulation denotes KD
T11385 902-913 Gene_expression denotes transfected
T11386 960-971 Gene_expression denotes transfected
T11387 1103-1114 Gene_expression denotes transfected
T11388 139-143 Protein denotes PKCα
T11389 980-984 Protein denotes PKCα
T11390 1123-1127 Protein denotes PKCα
T11391 1162-1166 Protein denotes PKCα
T11392 1297-1301 Protein denotes PKCα
T11393 3164-3168 Protein denotes PKCα
T11394 3175-3179 Protein denotes PKCα
T11395 3194-3203 Protein denotes Annexin V
T11396 3298-3307 Protein denotes Annexin V
T11397 3355-3359 Protein denotes PKCα
T11398 3422-3426 Protein denotes PKCα
T11399 144-145 Protein denotes β
T11400 3534-3538 Protein denotes PKCα
T11401 3616-3620 Protein denotes PKCα
T11402 3707-3710 Protein denotes p65
T11403 3775-3779 Protein denotes PKCα
T11404 3904-3908 Protein denotes PKCα
T11405 4040-4043 Protein denotes p65
T11406 4081-4085 Protein denotes PKCα
T11407 4159-4169 Protein denotes PKCα siRNA
T11408 4220-4230 Protein denotes PKCα siRNA
T11409 4329-4333 Protein denotes PKCα
T11410 242-246 Protein denotes PKCα
T11411 4526-4535 Protein denotes Annexin V
T11412 4563-4573 Protein denotes PKCα siRNA
T11413 4680-4690 Protein denotes PKCα siRNA
T11414 4787-4797 Protein denotes PKCα siRNA
T11415 4821-4825 Protein denotes PKCα
T11416 4905-4909 Protein denotes PKCα
T11417 326-330 Protein denotes PKCα
T11418 403-407 Protein denotes PKCα
T11419 3691-3697 Entity denotes Ser536
T11420 3750-3756 Entity denotes Ser276
T11421 433-437 Protein denotes PKCα
T11422 4024-4030 Entity denotes Ser276
T11423 592-596 Protein denotes PKCα
T11424 816-820 Protein denotes PKCα
T11425 897-901 Protein denotes PKCα
T11426 202-207 Protein denotes M-CSF
T11427 286-291 Protein denotes M-CSF
T11428 661-666 Protein denotes M-CSF
T11429 724-729 Protein denotes M-CSF
T11430 853-858 Protein denotes M-CSF
T11431 1040-1045 Protein denotes M-CSF
T11432 1206-1211 Protein denotes M-CSF
T11433 3239-3244 Protein denotes M-CSF
T11434 3437-3442 Protein denotes M-CSF
T11435 3849-3854 Protein denotes M-CSF
T11436 3925-3930 Protein denotes M-CSF
T11437 4096-4101 Protein denotes M-CSF
T11438 4306-4311 Protein denotes M-CSF
T11439 4355-4360 Protein denotes M-CSF
T11440 4611-4616 Protein denotes M-CSF
T11441 4941-4946 Protein denotes M-CSF
T11442 667-677 Positive_regulation denotes activation
T11443 1046-1056 Positive_regulation denotes activation
T11444 4283-4291 Positive_regulation denotes presence
T11445 4295-4302 Negative_regulation denotes absence
T26122 1352-1361 Regulation denotes regulates
T26123 1362-1377 Phosphorylation denotes phosphorylation
T26124 1450-1461 Gene_expression denotes transfected
T26125 1450-1461 Gene_expression denotes transfected
T26126 1512-1528 Negative_regulation denotes kinase-deficient
T26127 2179-2189 Gene_expression denotes expression
T26128 2367-2378 Gene_expression denotes transfected
T26129 1347-1351 Protein denotes PKCα
T26130 2778-2787 Protein denotes Annexin V
T26131 2988-2995 Protein denotes β-actin
T26132 1394-1400 Entity denotes Ser276
T26133 1387-1390 Protein denotes p65
T26134 1500-1504 Protein denotes PKCα
T26135 1534-1538 Protein denotes PKCα
T26136 1915-1924 Protein denotes Annexin V
T26137 2147-2151 Protein denotes PKCα
T26138 2198-2202 Protein denotes PKCα
T26139 2215-2222 Protein denotes β-actin
T26140 2423-2433 Protein denotes PKCα siRNA
T26141 1610-1615 Protein denotes M-CSF
T26142 2537-2542 Protein denotes M-CSF
R8665 T11363 T11364 causeOf KD,affect
R8666 T11363 T11367 causeOf KD,attenuated
R8667 T11366 T11364 themeOf phosphorylation,affect
R8668 T11368 T11367 themeOf phosphorylation,attenuated
R8669 T11369 T11370 causeOf Expression,effect
R8670 T11369 T11372 causeOf Expression,effect
R8671 T11370 T11374 themeOf effect,with or without
R8672 T11371 T11370 themeOf phosphorylation,effect
R8673 T11372 T11375 themeOf effect,with or without
R8674 T11373 T11372 themeOf phosphorylation,effect
R8675 T11379 T11378 themeOf expression,Reducing
R8676 T11381 T11380 themeOf expression,decreased
R8677 T11388 T11354 themeOf PKCα,inhibitors
R8678 T11389 T11386 themeOf PKCα,transfected
R8679 T11390 T11387 themeOf PKCα,transfected
R8680 T11391 T11355 themeOf PKCα,KD
R8681 T11392 T11356 themeOf PKCα,transfected
R8682 T11393 T11357 themeOf PKCα,expressing
R8683 T11394 T11358 themeOf PKCα,KD
R8684 T11396 T11359 themeOf Annexin V,negative
R8685 T11397 T11360 themeOf PKCα,expression
R8686 T11398 T11361 themeOf PKCα,KD
R8687 T11399 T11365 themeOf β,inhibitors
R8688 T11400 T11362 themeOf PKCα,expressing
R8689 T11401 T11363 themeOf PKCα,KD
R8690 T11403 T11369 themeOf PKCα,Expression
R8691 T11409 T11379 themeOf PKCα,expression
R8692 T11414 T11380 causeOf PKCα siRNA,decreased
R8693 T11415 T11381 themeOf PKCα,expression
R8694 T11418 T11382 themeOf PKCα,co-transfected
R8695 T11419 T11366 themeOf Ser536,phosphorylation
R8696 T11419 T11402 partOf Ser536,p65
R8697 T11419 T11371 themeOf Ser536,phosphorylation
R8698 T11420 T11368 themeOf Ser276,phosphorylation
R8699 T11420 T11402 partOf Ser276,p65
R8700 T11420 T11373 themeOf Ser276,phosphorylation
R8701 T11421 T11376 themeOf PKCα,kinase-deficient
R8702 T11422 T11377 themeOf Ser276,phosphorylation
R8703 T11422 T11405 partOf Ser276,p65
R8704 T11423 T11383 themeOf PKCα,co-transfected
R8705 T11424 T11384 themeOf PKCα,KD
R8706 T11425 T11385 themeOf PKCα,transfected
R8707 T11428 T11442 themeOf M-CSF,activation
R8708 T11431 T11443 themeOf M-CSF,activation
R8709 T11435 T11375 causeOf M-CSF,with or without
R8710 T11435 T11374 causeOf M-CSF,with or without
R8711 T11438 T11445 themeOf M-CSF,absence
R8712 T11438 T11444 themeOf M-CSF,presence
R20068 T26123 T26122 themeOf phosphorylation,regulates
R20069 T26129 T26122 causeOf PKCα,regulates
R20070 T26132 T26123 themeOf Ser276,phosphorylation
R20071 T26132 T26133 partOf Ser276,p65
R20072 T26134 T26124 themeOf PKCα,transfected
R20073 T26135 T26125 themeOf PKCα,transfected
R20074 T26135 T26126 themeOf PKCα,kinase-deficient
R20075 T26138 T26127 themeOf PKCα,expression
R20076 T26140 T26128 themeOf PKCα siRNA,transfected

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T12051 18-22 Protein denotes PKCα
T12052 30-48 Protein denotes Upstream Activator
T12053 52-57 Protein denotes NF-κB
T12054 91-101 Protein denotes PKC family
T12055 139-145 Protein denotes PKCα/β
T12056 202-207 Protein denotes M-CSF
T12057 216-221 Protein denotes NF-κB
T12058 242-246 Protein denotes PKCα
T12059 263-268 Protein denotes NF-κB
T12060 286-291 Protein denotes M-CSF
T12061 269-279 Positive_regulation denotes activation
T12062 326-336 Protein denotes PKCα in NF
T12063 337-339 Protein denotes κB
T12064 403-407 Protein denotes PKCα
T12065 433-437 Protein denotes PKCα
T12066 466-472 Protein denotes pNF-κB
T12067 473-477 Protein denotes SEAP
T12068 496-500 Protein denotes SEAP
T12069 340-350 Positive_regulation denotes activation
T12070 340-350 Positive_regulation denotes activation
T12071 501-510 Localization denotes secretion
T12072 573-579 Protein denotes pNF-κB
T12073 580-584 Protein denotes SEAP
T12074 589-596 Protein denotes WT-PKCα
T12075 624-629 Protein denotes NF-κB
T12076 661-666 Protein denotes M-CSF
T12077 724-729 Protein denotes M-CSF
T12078 760-766 Protein denotes pNF-κB
T12079 767-771 Protein denotes SEAP
T12080 667-677 Positive_regulation denotes activation
T12081 744-754 Gene_expression denotes expressing
T12082 744-754 Gene_expression denotes expressing
T12083 612-620 Positive_regulation denotes increase
T12084 813-830 Protein denotes KD-PKCα construct
T12085 853-858 Protein denotes M-CSF
T12086 867-872 Protein denotes NF-κB
T12087 894-896 Protein denotes WT
T12088 897-901 Protein denotes PKCα
T12089 859-866 Positive_regulation denotes induced
T12090 977-984 Protein denotes WT-PKCα
T12091 1003-1008 Protein denotes NF-κB
T12092 1040-1045 Protein denotes M-CSF
T12093 1120-1127 Protein denotes WT-PKCα
T12094 1046-1056 Positive_regulation denotes activation
T12095 1159-1176 Protein denotes KD-PKCα construct
T12096 1206-1211 Protein denotes M-CSF
T12097 1220-1225 Protein denotes NF-κB
T12098 1294-1301 Protein denotes WT PKCα
T12099 1141-1151 Gene_expression denotes Expression
T12100 1212-1219 Positive_regulation denotes induced
T12101 3161-3168 Protein denotes WT-PKCα
T12102 3172-3190 Protein denotes KD-PKCα constructs
T12103 3143-3153 Gene_expression denotes expressing
T12104 3143-3153 Gene_expression denotes expressing
T12105 3239-3244 Protein denotes M-CSF
T12106 3255-3258 Protein denotes MDM
T12107 3245-3254 Positive_regulation denotes increased
T12108 3352-3359 Protein denotes WT-PKCα
T12109 3338-3348 Gene_expression denotes expression
T12110 3419-3426 Protein denotes KD-PKCα
T12111 3437-3442 Protein denotes M-CSF
T12112 3405-3415 Gene_expression denotes expression
T12113 3427-3436 Negative_regulation denotes decreased
T12114 3534-3538 Protein denotes PKCα
T12115 3553-3558 Protein denotes NF-κB
T12116 3519-3529 Gene_expression denotes expressing
T12117 3519-3529 Gene_expression denotes expressing
T12118 3559-3574 Phosphorylation denotes phosphorylation
T12119 3559-3574 Phosphorylation denotes phosphorylation
T12120 3613-3620 Protein denotes KD-PKCα
T12121 3701-3706 Protein denotes NF-κB
T12122 3707-3710 Protein denotes p65
T12123 3599-3609 Gene_expression denotes expression
T12124 3672-3687 Phosphorylation denotes phosphorylation
T12125 3672-3687 Phosphorylation denotes phosphorylation
T12126 3691-3697 Positive_regulation denotes Ser536
T12127 3691-3697 Positive_regulation denotes Ser536
T12128 3772-3779 Protein denotes WT-PKCα
T12129 3849-3854 Protein denotes M-CSF
T12130 3758-3768 Gene_expression denotes Expression
T12131 3799-3814 Phosphorylation denotes phosphorylation
T12132 3788-3794 Positive_regulation denotes effect
T12133 3904-3908 Protein denotes PKCα
T12134 3925-3930 Protein denotes M-CSF
T12135 3959-3964 Protein denotes NF-κB
T12136 4034-4043 Protein denotes NF-κB p65
T12137 3912-3921 Localization denotes important
T12138 3965-3975 Positive_regulation denotes activation
T12139 4005-4020 Phosphorylation denotes phosphorylation
T12140 3931-3940 Regulation denotes regulated
T12141 3987-3996 Regulation denotes regulated
T12142 4081-4085 Protein denotes PKCα
T12143 4110-4115 Protein denotes NF-κB
T12144 4159-4169 Protein denotes PKCα siRNA
T12145 4220-4230 Protein denotes PKCα siRNA
T12146 4306-4311 Protein denotes M-CSF
T12147 4329-4333 Protein denotes PKCα
T12148 4355-4360 Protein denotes M-CSF
T12149 4369-4374 Protein denotes NF-κB
T12150 4334-4344 Gene_expression denotes expression
T12151 4361-4368 Positive_regulation denotes induced
T12152 4313-4321 Negative_regulation denotes Reducing
T12153 4345-4354 Negative_regulation denotes decreased
T12154 4563-4573 Protein denotes PKCα siRNA
T12155 4574-4586 Gene_expression denotes transfection
T12156 4574-4586 Positive_regulation denotes transfection
T12157 4680-4690 Protein denotes PKCα siRNA
T12158 4787-4797 Protein denotes PKCα siRNA
T12159 4821-4833 Protein denotes PKCα protein
T12160 4798-4810 Gene_expression denotes transfection
T12161 4798-4810 Positive_regulation denotes transfection
T12162 4834-4844 Gene_expression denotes expression
T12163 4905-4909 Protein denotes PKCα
T12164 4920-4925 Protein denotes NF-κB
T12165 4941-4946 Protein denotes M-CSF
T12166 4926-4936 Positive_regulation denotes activation
T12167 4947-4956 Regulation denotes regulated
T12168 4910-4919 Regulation denotes regulated
T26295 1347-1351 Protein denotes PKCα
T26296 1381-1390 Protein denotes NF-κB p65
T26297 1362-1377 Phosphorylation denotes phosphorylation
T26298 1352-1361 Regulation denotes regulates
T26299 1467-1473 Protein denotes pNF-κB
T26300 1474-1478 Protein denotes SEAP
T26301 1497-1504 Protein denotes WT-PKCα
T26302 1534-1538 Protein denotes PKCα
T26303 1610-1615 Protein denotes M-CSF
T26304 2095-2115 Protein denotes NF-κB p65 antibodies
T26305 2147-2151 Protein denotes PKCα
T26306 2198-2202 Protein denotes PKCα
T26307 2215-2222 Protein denotes β-actin
T26308 2179-2189 Gene_expression denotes expression
T26309 2179-2189 Gene_expression denotes expression
T26310 2386-2392 Protein denotes pNF-κB
T26311 2393-2397 Protein denotes SEAP
T26312 2423-2450 Protein denotes PKCα siRNA or control siRNA
T26313 2973-2986 Protein denotes PKCα antibody
T26314 2988-2995 Protein denotes β-actin
R8975 T12059 T12061 themeOf NF-κB,activation
R8976 T12062 T12069 themeOf PKCα in NF,activation
R8977 T12063 T12070 themeOf κB,activation
R8978 T12068 T12071 themeOf SEAP,secretion
R8979 T12075 T12083 themeOf NF-κB,increase
R8980 T12076 T12080 themeOf M-CSF,activation
R8981 T12078 T12081 themeOf pNF-κB,expressing
R8982 T12079 T12082 themeOf SEAP,expressing
R8983 T12080 T12083 causeOf activation,increase
R8984 T12085 T12089 causeOf M-CSF,induced
R8985 T12086 T12089 themeOf NF-κB,induced
R8986 T12092 T12094 themeOf M-CSF,activation
R8987 T12095 T12099 themeOf KD-PKCα construct,Expression
R8988 T12096 T12100 causeOf M-CSF,induced
R8989 T12097 T12100 themeOf NF-κB,induced
R8990 T12101 T12103 themeOf WT-PKCα,expressing
R8991 T12102 T12104 themeOf KD-PKCα constructs,expressing
R8992 T12105 T12107 causeOf M-CSF,increased
R8993 T12106 T12107 themeOf MDM,increased
R8994 T12108 T12109 themeOf WT-PKCα,expression
R8995 T12110 T12112 themeOf KD-PKCα,expression
R8996 T12112 T12113 themeOf expression,decreased
R8997 T12114 T12116 themeOf PKCα,expressing
R8998 T12114 T12118 themeOf PKCα,phosphorylation
R8999 T12115 T12117 themeOf NF-κB,expressing
R9000 T12115 T12119 themeOf NF-κB,phosphorylation
R9001 T12120 T12123 themeOf KD-PKCα,expression
R9002 T12121 T12124 themeOf NF-κB,phosphorylation
R9003 T12121 T12126 themeOf NF-κB,Ser536
R9004 T12122 T12125 themeOf p65,phosphorylation
R9005 T12122 T12127 themeOf p65,Ser536
R9006 T12128 T12130 themeOf WT-PKCα,Expression
R9007 T12129 T12131 themeOf M-CSF,phosphorylation
R9008 T12130 T12132 causeOf Expression,effect
R9009 T12131 T12132 themeOf phosphorylation,effect
R9010 T12133 T12137 themeOf PKCα,important
R9011 T12133 T12141 causeOf PKCα,regulated
R9012 T12134 T12140 causeOf M-CSF,regulated
R9013 T12135 T12138 themeOf NF-κB,activation
R9014 T12136 T12139 themeOf NF-κB p65,phosphorylation
R9015 T12138 T12140 themeOf activation,regulated
R9016 T12139 T12141 themeOf phosphorylation,regulated
R9017 T12147 T12150 themeOf PKCα,expression
R9018 T12148 T12151 causeOf M-CSF,induced
R9019 T12149 T12151 themeOf NF-κB,induced
R9020 T12150 T12152 themeOf expression,Reducing
R9021 T12151 T12153 themeOf induced,decreased
R9022 T12154 T12155 themeOf PKCα siRNA,transfection
R9023 T12155 T12156 themeOf transfection,transfection
R9024 T12158 T12160 themeOf PKCα siRNA,transfection
R9025 T12159 T12162 themeOf PKCα protein,expression
R9026 T12160 T12161 themeOf transfection,transfection
R9027 T12163 T12168 causeOf PKCα,regulated
R9028 T12164 T12166 themeOf NF-κB,activation
R9029 T12165 T12167 causeOf M-CSF,regulated
R9030 T12166 T12167 themeOf activation,regulated
R9031 T12166 T12168 themeOf activation,regulated
R20129 T26295 T26298 causeOf PKCα,regulates
R20130 T26296 T26297 themeOf NF-κB p65,phosphorylation
R20131 T26297 T26298 themeOf phosphorylation,regulates
R20132 T26306 T26308 themeOf PKCα,expression
R20133 T26307 T26309 themeOf β-actin,expression

events-check-again

Id Subject Object Predicate Lexical cue Negation
T11959 139-143 Protein denotes PKCα
T11960 144-145 Protein denotes β
T11961 146-156 Negative_regulation denotes inhibitors
T11962 146-156 Negative_regulation denotes inhibitors
T11963 202-207 Protein denotes M-CSF
T11964 242-246 Protein denotes PKCα
T11965 286-291 Protein denotes M-CSF
T11966 326-330 Protein denotes PKCα
T11967 403-407 Protein denotes PKCα
T11968 411-427 Negative_regulation denotes kinase-deficient
T11969 433-437 Protein denotes PKCα
T11970 442-456 Gene_expression denotes co-transfected
T11971 553-567 Gene_expression denotes co-transfected
T11972 592-596 Protein denotes PKCα
T11973 661-666 Protein denotes M-CSF
T11974 667-677 Positive_regulation denotes activation
T11975 724-729 Protein denotes M-CSF
T11976 813-815 Negative_regulation denotes KD
T11977 816-820 Protein denotes PKCα
T11978 853-858 Protein denotes M-CSF
T11979 897-901 Protein denotes PKCα
T11980 902-913 Gene_expression denotes transfected
T11981 960-971 Gene_expression denotes transfected
T11982 980-984 Protein denotes PKCα
T11983 1040-1045 Protein denotes M-CSF
T11984 1046-1056 Positive_regulation denotes activation
T11985 1103-1114 Gene_expression denotes transfected
T11986 1123-1127 Protein denotes PKCα
T11987 1159-1161 Negative_regulation denotes KD
T11988 1162-1166 Protein denotes PKCα
T11989 1206-1211 Protein denotes M-CSF
T11990 1277-1288 Gene_expression denotes transfected
T11991 1297-1301 Protein denotes PKCα
T11992 3143-3153 Gene_expression denotes expressing
T11993 3164-3168 Protein denotes PKCα
T11994 3172-3174 Negative_regulation denotes KD
T11995 3175-3179 Protein denotes PKCα
T11996 3194-3203 Protein denotes Annexin V
T11997 3239-3244 Protein denotes M-CSF
T11998 3298-3307 Protein denotes Annexin V
T11999 3311-3319 Negative_regulation denotes negative
T12000 3338-3348 Gene_expression denotes expression
T12001 3355-3359 Protein denotes PKCα
T12002 3419-3421 Negative_regulation denotes KD
T12003 3422-3426 Protein denotes PKCα
T12004 3437-3442 Protein denotes M-CSF
T12005 3519-3529 Gene_expression denotes expressing
T12006 3534-3538 Protein denotes PKCα
T12007 3613-3615 Negative_regulation denotes KD
T12008 3616-3620 Protein denotes PKCα
T12009 3648-3654 Regulation denotes affect true
T12010 3672-3687 Phosphorylation denotes phosphorylation
T12011 3691-3697 Entity denotes Ser536
T12012 3707-3710 Protein denotes p65
T12013 3716-3726 Negative_regulation denotes attenuated
T12014 3731-3746 Phosphorylation denotes phosphorylation
T12015 3750-3756 Entity denotes Ser276
T12016 3758-3768 Gene_expression denotes Expression
T12017 3775-3779 Protein denotes PKCα
T12018 3788-3794 Regulation denotes effect true
T12019 3788-3794 Regulation denotes effect true
T12020 3799-3814 Phosphorylation denotes phosphorylation
T12021 3799-3814 Phosphorylation denotes phosphorylation
T12022 3833-3848 Regulation denotes with or without true
T12023 3833-3848 Regulation denotes with or without true
T12024 3849-3854 Protein denotes M-CSF
T12025 3904-3908 Protein denotes PKCα
T12026 3925-3930 Protein denotes M-CSF
T12027 4005-4020 Phosphorylation denotes phosphorylation
T12028 4024-4030 Entity denotes Ser276
T12029 4040-4043 Protein denotes p65
T12030 4081-4085 Protein denotes PKCα
T12031 4096-4101 Protein denotes M-CSF
T12032 4159-4169 Protein denotes PKCα siRNA
T12033 4220-4230 Protein denotes PKCα siRNA
T12034 4283-4291 Positive_regulation denotes presence
T12035 4295-4302 Negative_regulation denotes absence
T12036 4306-4311 Protein denotes M-CSF
T12037 4313-4321 Negative_regulation denotes Reducing
T12038 4329-4333 Protein denotes PKCα
T12039 4334-4344 Gene_expression denotes expression
T12040 4355-4360 Protein denotes M-CSF
T12041 4526-4535 Protein denotes Annexin V
T12042 4563-4573 Protein denotes PKCα siRNA
T12043 4611-4616 Protein denotes M-CSF
T12044 4680-4690 Protein denotes PKCα siRNA
T12045 4787-4797 Protein denotes PKCα siRNA
T12046 4811-4820 Negative_regulation denotes decreased
T12047 4821-4825 Protein denotes PKCα
T12048 4834-4844 Gene_expression denotes expression
T12049 4905-4909 Protein denotes PKCα
T12050 4941-4946 Protein denotes M-CSF
T26274 1347-1351 Protein denotes PKCα
T26275 1352-1361 Regulation denotes regulates
T26276 1362-1377 Phosphorylation denotes phosphorylation
T26277 1387-1390 Protein denotes p65
T26278 1394-1400 Entity denotes Ser276
T26279 1450-1461 Gene_expression denotes transfected
T26280 1450-1461 Gene_expression denotes transfected
T26281 1500-1504 Protein denotes PKCα
T26282 1512-1528 Negative_regulation denotes kinase-deficient
T26283 1534-1538 Protein denotes PKCα
T26284 1610-1615 Protein denotes M-CSF
T26285 1915-1924 Protein denotes Annexin V
T26286 2147-2151 Protein denotes PKCα
T26287 2179-2189 Gene_expression denotes expression
T26288 2198-2202 Protein denotes PKCα
T26289 2215-2222 Protein denotes β-actin
T26290 2367-2378 Gene_expression denotes transfected
T26291 2423-2433 Protein denotes PKCα siRNA
T26292 2537-2542 Protein denotes M-CSF
T26293 2778-2787 Protein denotes Annexin V
T26294 2988-2995 Protein denotes β-actin
R8927 T11959 T11961 themeOf PKCα,inhibitors
R8928 T11960 T11962 themeOf β,inhibitors
R8929 T11967 T11970 themeOf PKCα,co-transfected
R8930 T11969 T11968 themeOf PKCα,kinase-deficient
R8931 T11972 T11971 themeOf PKCα,co-transfected
R8932 T11973 T11974 themeOf M-CSF,activation
R8933 T11977 T11976 themeOf PKCα,KD
R8934 T11979 T11980 themeOf PKCα,transfected
R8935 T11982 T11981 themeOf PKCα,transfected
R8936 T11983 T11984 themeOf M-CSF,activation
R8937 T11986 T11985 themeOf PKCα,transfected
R8938 T11988 T11987 themeOf PKCα,KD
R8939 T11991 T11990 themeOf PKCα,transfected
R8940 T11993 T11992 themeOf PKCα,expressing
R8941 T11995 T11994 themeOf PKCα,KD
R8942 T11998 T11999 themeOf Annexin V,negative
R8943 T12001 T12000 themeOf PKCα,expression
R8944 T12003 T12002 themeOf PKCα,KD
R8945 T12006 T12005 themeOf PKCα,expressing
R8946 T12007 T12009 causeOf KD,affect
R8947 T12007 T12013 causeOf KD,attenuated
R8948 T12008 T12007 themeOf PKCα,KD
R8949 T12010 T12009 themeOf phosphorylation,affect
R8950 T12011 T12010 themeOf Ser536,phosphorylation
R8951 T12011 T12012 partOf Ser536,p65
R8952 T12011 T12020 themeOf Ser536,phosphorylation
R8953 T12014 T12013 themeOf phosphorylation,attenuated
R8954 T12015 T12014 themeOf Ser276,phosphorylation
R8955 T12015 T12012 partOf Ser276,p65
R8956 T12015 T12021 themeOf Ser276,phosphorylation
R8957 T12016 T12018 causeOf Expression,effect
R8958 T12016 T12019 causeOf Expression,effect
R8959 T12017 T12016 themeOf PKCα,Expression
R8960 T12018 T12022 themeOf effect,with or without
R8961 T12019 T12023 themeOf effect,with or without
R8962 T12020 T12018 themeOf phosphorylation,effect
R8963 T12021 T12019 themeOf phosphorylation,effect
R8964 T12024 T12023 causeOf M-CSF,with or without
R8965 T12024 T12022 causeOf M-CSF,with or without
R8966 T12028 T12027 themeOf Ser276,phosphorylation
R8967 T12028 T12029 partOf Ser276,p65
R8968 T12036 T12035 themeOf M-CSF,absence
R8969 T12036 T12034 themeOf M-CSF,presence
R8970 T12038 T12039 themeOf PKCα,expression
R8971 T12039 T12037 themeOf expression,Reducing
R8972 T12045 T12046 causeOf PKCα siRNA,decreased
R8973 T12047 T12048 themeOf PKCα,expression
R8974 T12048 T12046 themeOf expression,decreased
R20120 T26274 T26275 causeOf PKCα,regulates
R20121 T26276 T26275 themeOf phosphorylation,regulates
R20122 T26278 T26276 themeOf Ser276,phosphorylation
R20123 T26278 T26277 partOf Ser276,p65
R20124 T26281 T26279 themeOf PKCα,transfected
R20125 T26283 T26280 themeOf PKCα,transfected
R20126 T26283 T26282 themeOf PKCα,kinase-deficient
R20127 T26288 T26287 themeOf PKCα,expression
R20128 T26291 T26290 themeOf PKCα siRNA,transfected

GO-CC

Id Subject Object Predicate Lexical cue
T11498 161-174 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T11499 695-700 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11500 738-743 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11501 914-919 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11502 954-959 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11503 1092-1097 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11504 1192-1197 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11505 1271-1276 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11506 3320-3325 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11507 3370-3375 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11508 3634-3639 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11509 4194-4199 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11510 4270-4275 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11511 4450-4455 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11512 4657-4662 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11513 4705-4710 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11514 4871-4876 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11515 4957-4961 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T26162 1427-1432 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T26163 1730-1735 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T26164 2011-2016 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T26165 2344-2349 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T26166 2922-2927 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T26167 2105-2115 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T26168 2978-2986 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T26169 2105-2115 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T26170 2978-2986 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody

GO-MF

Id Subject Object Predicate Lexical cue
T11468 18-22 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11469 139-143 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11470 242-246 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11471 326-330 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11472 403-407 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11473 433-437 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11474 592-596 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11475 816-820 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11476 897-901 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11477 980-984 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11478 1123-1127 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11479 1162-1166 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11480 1297-1301 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11481 3164-3168 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11482 3175-3179 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11483 3355-3359 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11484 3422-3426 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11485 3534-3538 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11486 3616-3620 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11487 3775-3779 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11488 3904-3908 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11489 4081-4085 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11490 4159-4163 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11491 4220-4224 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11492 4329-4333 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11493 4563-4567 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11494 4680-4684 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11495 4787-4791 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11496 4821-4825 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T11497 91-94 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T26153 1347-1351 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T26154 1500-1504 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T26155 1534-1538 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T26156 2147-2151 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T26157 2198-2202 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T26158 2423-2427 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T26159 2973-2977 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T26160 2105-2115 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T26161 2978-2986 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody

GO-BP

Id Subject Object Predicate Lexical cue
T12169 263-279 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T12170 334-350 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T12171 3959-3975 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T12172 4920-4936 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T12173 501-510 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T12174 630-645 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T12175 1009-1024 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T12176 4116-4131 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T12177 4375-4390 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T12178 661-677 http://purl.obolibrary.org/obo/GO_1901258 denotes M-CSF activation
T12179 1040-1056 http://purl.obolibrary.org/obo/GO_1901258 denotes M-CSF activation
T12180 661-677 http://purl.obolibrary.org/obo/GO_1903971 denotes M-CSF activation
T12181 1040-1056 http://purl.obolibrary.org/obo/GO_1903971 denotes M-CSF activation
T12182 3381-3390 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T12183 3381-3390 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T12184 3553-3574 http://purl.obolibrary.org/obo/GO_0007252 denotes NF-κB phosphorylation
T12185 3559-3574 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T12186 3672-3687 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T12187 3731-3746 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T12188 3799-3814 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T12189 4005-4020 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T26315 2602-2611 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T26316 1860-1869 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T26317 2744-2753 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T26318 1860-1869 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T26319 2744-2753 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T26320 1362-1377 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T26321 1630-1639 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion

UBERON-AE

Id Subject Object Predicate Lexical cue
T25463 1576-1581 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T25464 2479-2484 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T11284 3750-3756 Antecedent denotes Ser276
T11282 3818-3832 Anaphor denotes either residue
T11283 3691-3697 Antecedent denotes Ser536
R8663 T11282 T11283 boundBy either residue,Ser536
R8664 T11282 T11284 boundBy either residue,Ser276

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T10779 0-14 NN denotes Identification
T10780 15-17 IN denotes of
T10781 18-22 NN denotes PKCα
T10782 23-25 IN denotes as
T10783 26-29 DT denotes the
T10784 30-38 NNP denotes Upstream
T10785 39-48 NN denotes Activator
T10786 49-51 IN denotes of
T10787 52-57 NN denotes NF-κB
T10788 58-60 IN denotes in
T10789 61-68 JJ denotes Myeloid
T10790 69-74 NN denotes Cells
T10791 75-79 RB denotes Even
T10792 80-86 IN denotes though
T10793 87-90 DT denotes the
T10794 91-94 NN denotes PKC
T10795 95-101 NN denotes family
T10796 102-110 VB denotes consists
T10797 111-113 IN denotes of
T10798 114-116 CD denotes 10
T10799 117-124 NN denotes members
T10800 124-125 -COMMA- denotes ,
T10801 126-133 VB denotes finding
T10802 134-138 IN denotes that
T10803 139-145 NN denotes PKCα/β
T10804 146-156 NN denotes inhibitors
T10805 157-160 CC denotes and
T10806 161-174 JJ denotes intracellular
T10807 175-182 NN denotes calcium
T10808 183-193 NN denotes inhibitors
T10809 194-201 VB denotes reduced
T10810 202-215 JJ denotes M-CSF-induced
T10811 216-221 NN denotes NF-κB
T10812 222-230 NN denotes activity
T10813 230-231 -COMMA- denotes ,
T10814 232-241 VB denotes suggested
T10815 242-246 NN denotes PKCα
T10816 247-250 VB denotes was
T10817 251-259 VB denotes involved
T10818 260-262 IN denotes in
T10819 263-268 NN denotes NF-κB
T10820 269-279 NN denotes activation
T10821 280-285 IN denotes after
T10822 286-291 NN denotes M-CSF
T10823 292-301 NN denotes treatment
T10824 303-305 TO denotes To
T10825 306-313 VB denotes confirm
T10826 314-317 DT denotes the
T10827 318-322 NN denotes role
T10828 323-325 IN denotes of
T10829 326-330 NN denotes PKCα
T10830 331-333 IN denotes in
T10831 334-339 NN denotes NF-κB
T10832 340-350 NN denotes activation
T10833 351-353 IN denotes in
T10834 354-365 NN denotes macrophages
T10835 365-366 -COMMA- denotes ,
T10836 367-377 NN denotes constructs
T10837 378-381 IN denotes for
T10838 382-388 CC denotes either
T10839 389-397 NN denotes wildtype
T10840 398-399 -LRB- denotes (
T10841 399-401 NN denotes WT
T10842 401-402 -RRB- denotes )
T10843 402-407 NN denotes -PKCα
T10844 408-410 CC denotes or
T10845 411-427 JJ denotes kinase-deficient
T10846 428-429 -LRB- denotes (
T10847 429-431 NN denotes KD
T10848 431-432 -RRB- denotes )
T10849 432-437 NN denotes -PKCα
T10850 438-441 VB denotes was
T10851 442-456 VB denotes co-transfected
T10852 457-461 IN denotes with
T10853 462-465 DT denotes the
T10854 466-477 NN denotes pNF-κB-SEAP
T10855 478-486 NN denotes reporter
T10856 487-491 NN denotes gene
T10857 492-495 CC denotes and
T10858 496-500 NN denotes SEAP
T10859 501-510 NN denotes secretion
T10860 511-514 VB denotes was
T10861 515-523 VB denotes measured
T10862 525-527 IN denotes As
T10863 528-533 VB denotes shown
T10864 534-536 IN denotes in
T10865 537-543 NNP denotes Figure
T10866 544-546 NNP denotes 7A
T10867 546-547 -COMMA- denotes ,
T10868 548-552 NN denotes MDMs
T10869 553-567 VB denotes co-transfected
T10870 568-572 IN denotes with
T10871 573-584 NN denotes pNF-κB-SEAP
T10872 585-588 CC denotes and
T10873 589-596 NNP denotes WT-PKCα
T10874 597-600 VB denotes had
T10875 601-602 DT denotes a
T10876 603-611 JJ denotes 1.8-fold
T10877 612-620 NN denotes increase
T10878 621-623 IN denotes in
T10879 624-629 NN denotes NF-κB
T10880 630-645 JJ denotes transcriptional
T10881 646-654 NN denotes activity
T10882 655-660 IN denotes after
T10883 661-666 NN denotes M-CSF
T10884 667-677 NN denotes activation
T10885 678-686 VB denotes compared
T10886 687-691 IN denotes with
T10887 692-694 NN denotes NS
T10888 695-700 NN denotes cells
T10889 701-702 -LRB- denotes (
T10890 702-710 NN denotes p = 0.05
T10891 710-711 -RRB- denotes )
T10892 711-712 -COMMA- denotes ,
T10893 713-720 JJ denotes similar
T10894 721-723 TO denotes to
T10895 724-737 JJ denotes M-CSF-treated
T10896 738-743 NN denotes cells
T10897 744-754 VB denotes expressing
T10898 755-759 RB denotes only
T10899 760-771 NN denotes pNF-κB-SEAP
T10900 773-785 VB denotes Transfecting
T10901 786-791 JJ denotes human
T10902 792-803 NN denotes macrophages
T10903 804-808 IN denotes with
T10904 809-812 DT denotes the
T10905 813-820 NN denotes KD-PKCα
T10906 821-830 NN denotes construct
T10907 831-844 RB denotes significantly
T10908 845-852 VB denotes reduced
T10909 853-866 JJ denotes M-CSF-induced
T10910 867-872 NN denotes NF-κB
T10911 873-881 NN denotes activity
T10912 882-890 VB denotes compared
T10913 891-893 TO denotes to
T10914 894-901 JJ denotes WT-PKCα
T10915 902-913 VB denotes transfected
T10916 914-919 NN denotes cells
T10917 920-921 -LRB- denotes (
T10918 921-930 NN denotes p = 0.016
T10919 930-931 -RRB- denotes )
T10920 933-942 RB denotes Similarly
T10921 942-943 -COMMA- denotes ,
T10922 944-947 NN denotes RAW
T10923 948-953 CD denotes 264.7
T10924 954-959 NN denotes cells
T10925 960-971 VB denotes transfected
T10926 972-976 IN denotes with
T10927 977-984 NNP denotes WT-PKCα
T10928 985-988 VB denotes had
T10929 989-997 RB denotes 2.5-fold
T10930 998-1002 JJ denotes more
T10931 1003-1008 NN denotes NF-κB
T10932 1009-1024 JJ denotes transcriptional
T10933 1025-1033 NN denotes activity
T10934 1034-1039 IN denotes after
T10935 1040-1045 NN denotes M-CSF
T10936 1046-1056 NN denotes activation
T10937 1057-1065 VB denotes compared
T10938 1066-1068 TO denotes to
T10939 1069-1081 JJ denotes unstimulated
T10940 1082-1085 NN denotes RAW
T10941 1086-1091 CD denotes 264.7
T10942 1092-1097 NN denotes cells
T10943 1098-1099 -LRB- denotes (
T10944 1099-1101 NN denotes NS
T10945 1101-1102 -RRB- denotes )
T10946 1103-1114 VB denotes transfected
T10947 1115-1119 IN denotes with
T10948 1120-1127 JJ denotes WT-PKCα
T10949 1128-1129 -LRB- denotes (
T10950 1129-1135 NN denotes Figure
T10951 1136-1138 NN denotes 7B
T10952 1138-1139 -RRB- denotes )
T10953 1141-1151 NN denotes Expression
T10954 1152-1154 IN denotes of
T10955 1155-1158 DT denotes the
T10956 1159-1166 NN denotes KD-PKCα
T10957 1167-1176 NN denotes construct
T10958 1177-1181 IN denotes into
T10959 1182-1185 NN denotes RAW
T10960 1186-1191 CD denotes 264.7
T10961 1192-1197 NN denotes cells
T10962 1198-1205 VB denotes reduced
T10963 1206-1219 JJ denotes M-CSF-induced
T10964 1220-1225 NN denotes NF-κB
T10965 1226-1234 NN denotes activity
T10966 1235-1237 TO denotes to
T10967 1238-1246 RB denotes 1.5-fold
T10968 1247-1248 -LRB- denotes (
T10969 1248-1257 NN denotes p = 0.045
T10970 1257-1258 -RRB- denotes )
T10971 1259-1267 VB denotes compared
T10972 1268-1270 TO denotes to
T10973 1271-1276 NN denotes cells
T10974 1277-1288 VB denotes transfected
T10975 1289-1293 IN denotes with
T10976 1294-1296 JJ denotes WT
T10977 1297-1301 NN denotes PKCα
T10978 3103-3107 NN denotes Cell
T10979 3108-3116 NN denotes survival
T10980 3117-3120 VB denotes was
T10981 3121-3125 RB denotes also
T10982 3126-3134 VB denotes examined
T10983 3135-3137 IN denotes in
T10984 3138-3142 NN denotes MDMs
T10985 3143-3153 VB denotes expressing
T10986 3154-3160 CC denotes either
T10987 3161-3168 JJ denotes WT-PKCα
T10988 3169-3171 CC denotes or
T10989 3172-3179 NN denotes KD-PKCα
T10990 3180-3190 NN denotes constructs
T10991 3191-3193 IN denotes by
T10992 3194-3201 NN denotes Annexin
T10993 3202-3208 NN denotes V-FITC
T10994 3209-3212 CC denotes and
T10995 3213-3215 NN denotes PI
T10996 3216-3224 NN denotes staining
T10997 3226-3228 IN denotes As
T10998 3229-3237 VB denotes expected
T10999 3237-3238 -COMMA- denotes ,
T11000 3239-3244 NN denotes M-CSF
T11001 3245-3254 VB denotes increased
T11002 3255-3258 NN denotes MDM
T11003 3259-3267 NN denotes survival
T11004 3268-3270 IN denotes as
T11005 3271-3279 VB denotes measured
T11006 3280-3282 IN denotes by
T11007 3283-3286 DT denotes the
T11008 3287-3294 NN denotes percent
T11009 3295-3297 IN denotes of
T11010 3298-3305 NN denotes Annexin
T11011 3306-3310 NNP denotes V/PI
T11012 3311-3319 JJ denotes negative
T11013 3320-3325 NN denotes cells
T11014 3327-3336 RB denotes Similarly
T11015 3336-3337 -COMMA- denotes ,
T11016 3338-3348 NN denotes expression
T11017 3349-3351 IN denotes of
T11018 3352-3359 JJ denotes WT-PKCα
T11019 3360-3369 JJ denotes protected
T11020 3370-3375 NN denotes cells
T11021 3376-3380 IN denotes from
T11022 3381-3390 NN denotes apoptosis
T11023 3392-3394 IN denotes In
T11024 3395-3403 NN denotes contrast
T11025 3403-3404 -COMMA- denotes ,
T11026 3405-3415 NN denotes expression
T11027 3416-3418 IN denotes of
T11028 3419-3426 NN denotes KD-PKCα
T11029 3427-3436 VB denotes decreased
T11030 3437-3450 JJ denotes M-CSF-induced
T11031 3451-3455 NN denotes cell
T11032 3456-3464 NN denotes survival
T11033 3465-3466 -LRB- denotes (
T11034 3466-3467 NN denotes p
T11035 3467-3468 SYM denotes <
T11036 3468-3472 CD denotes 0.01
T11037 3472-3473 -RRB- denotes )
T11038 3474-3475 -LRB- denotes (
T11039 3475-3481 NN denotes Figure
T11040 3482-3484 NN denotes 7C
T11041 3484-3485 -RRB- denotes )
T11042 3487-3491 RB denotes Next
T11043 3491-3492 -COMMA- denotes ,
T11044 3493-3495 PRP denotes we
T11045 3496-3504 VB denotes examined
T11046 3505-3508 DT denotes the
T11047 3509-3515 NN denotes effect
T11048 3516-3518 IN denotes of
T11049 3519-3529 VB denotes expressing
T11050 3530-3533 DT denotes the
T11051 3534-3538 NN denotes PKCα
T11052 3539-3549 NN denotes constructs
T11053 3550-3552 IN denotes on
T11054 3553-3558 NN denotes NF-κB
T11055 3559-3574 NN denotes phosphorylation
T11056 3576-3578 IN denotes As
T11057 3579-3584 VB denotes shown
T11058 3585-3587 IN denotes in
T11059 3588-3594 NNP denotes Figure
T11060 3595-3597 NN denotes 7D
T11061 3597-3598 -COMMA- denotes ,
T11062 3599-3609 NN denotes expression
T11063 3610-3612 IN denotes of
T11064 3613-3620 NN denotes KD-PKCα
T11065 3621-3623 IN denotes in
T11066 3624-3627 NN denotes RAW
T11067 3628-3633 CD denotes 264.7
T11068 3634-3639 NN denotes cells
T11069 3640-3643 VB denotes did
T11070 3644-3647 RB denotes not
T11071 3648-3654 VB denotes affect
T11072 3655-3658 DT denotes the
T11073 3659-3671 JJ denotes constitutive
T11074 3672-3687 NN denotes phosphorylation
T11075 3688-3690 IN denotes at
T11076 3691-3697 NN denotes Ser536
T11077 3698-3700 IN denotes of
T11078 3701-3706 NN denotes NF-κB
T11079 3707-3710 NN denotes p65
T11080 3710-3711 -COMMA- denotes ,
T11081 3712-3715 CC denotes but
T11082 3716-3726 VB denotes attenuated
T11083 3727-3730 DT denotes the
T11084 3731-3746 NN denotes phosphorylation
T11085 3747-3749 IN denotes at
T11086 3750-3756 NN denotes Ser276
T11087 3758-3768 NN denotes Expression
T11088 3769-3771 IN denotes of
T11089 3772-3779 NN denotes WT-PKCα
T11090 3780-3783 VB denotes did
T11091 3784-3787 RB denotes not
T11092 3788-3794 VB denotes effect
T11093 3795-3798 DT denotes the
T11094 3799-3814 NN denotes phosphorylation
T11095 3815-3817 IN denotes of
T11096 3818-3824 CC denotes either
T11097 3825-3832 NN denotes residue
T11098 3833-3837 IN denotes with
T11099 3838-3840 CC denotes or
T11100 3841-3848 IN denotes without
T11101 3849-3854 NN denotes M-CSF
T11102 3855-3866 NN denotes stimulation
T11103 3868-3873 DT denotes These
T11104 3874-3886 NN denotes observations
T11105 3887-3898 VB denotes demonstrate
T11106 3899-3903 IN denotes that
T11107 3904-3908 NN denotes PKCα
T11108 3909-3911 VB denotes is
T11109 3912-3921 JJ denotes important
T11110 3922-3924 IN denotes in
T11111 3925-3940 JJ denotes M-CSF-regulated
T11112 3941-3945 NN denotes cell
T11113 3946-3954 NN denotes survival
T11114 3955-3958 CC denotes and
T11115 3959-3964 NN denotes NF-κB
T11116 3965-3975 NN denotes activation
T11117 3976-3979 CC denotes and
T11118 3980-3986 RB denotes likely
T11119 3987-3996 VB denotes regulated
T11120 3997-4004 IN denotes through
T11121 4005-4020 NN denotes phosphorylation
T11122 4021-4023 IN denotes of
T11123 4024-4030 NN denotes Ser276
T11124 4031-4033 IN denotes of
T11125 4034-4039 NN denotes NF-κB
T11126 4040-4043 NN denotes p65
T11127 4045-4047 TO denotes To
T11128 4048-4055 RB denotes further
T11129 4056-4064 VB denotes validate
T11130 4065-4068 DT denotes the
T11131 4069-4075 NN denotes impact
T11132 4076-4080 IN denotes that
T11133 4081-4085 NN denotes PKCα
T11134 4086-4092 VB denotes played
T11135 4093-4095 IN denotes in
T11136 4096-4109 JJ denotes M-CSF-induced
T11137 4110-4115 NN denotes NF-κB
T11138 4116-4131 JJ denotes transcriptional
T11139 4132-4140 NN denotes activity
T11140 4140-4141 -COMMA- denotes ,
T11141 4142-4144 PRP denotes we
T11142 4145-4149 RB denotes next
T11143 4150-4158 VB denotes employed
T11144 4159-4163 NN denotes PKCα
T11145 4164-4169 NN denotes siRNA
T11146 4170-4179 NN denotes treatment
T11147 4180-4182 IN denotes of
T11148 4183-4186 NN denotes MDM
T11149 4187-4189 CC denotes or
T11150 4190-4193 NN denotes RAW
T11151 4194-4199 NN denotes cells
T11152 4201-4202 DT denotes A
T11153 4203-4207 NN denotes pool
T11154 4208-4210 IN denotes of
T11155 4211-4219 JJ denotes specific
T11156 4220-4224 NN denotes PKCα
T11157 4225-4230 NN denotes siRNA
T11158 4231-4235 VB denotes were
T11159 4236-4247 VB denotes transfected
T11160 4248-4252 IN denotes into
T11161 4253-4256 NN denotes MDM
T11162 4257-4259 CC denotes or
T11163 4260-4263 NN denotes Raw
T11164 4264-4269 CD denotes 264.7
T11165 4270-4275 NN denotes cells
T11166 4276-4278 IN denotes in
T11167 4279-4282 DT denotes the
T11168 4283-4291 NN denotes presence
T11169 4292-4294 CC denotes or
T11170 4295-4302 NN denotes absence
T11171 4303-4305 CC denotes or
T11172 4306-4311 NN denotes M-CSF
T11173 4313-4321 VB denotes Reducing
T11174 4322-4328 JJ denotes native
T11175 4329-4333 NN denotes PKCα
T11176 4334-4344 NN denotes expression
T11177 4345-4354 VB denotes decreased
T11178 4355-4368 JJ denotes M-CSF-induced
T11179 4369-4374 NN denotes NF-κB
T11180 4375-4390 JJ denotes transcriptional
T11181 4391-4399 NN denotes activity
T11182 4400-4402 IN denotes in
T11183 4403-4407 CC denotes both
T11184 4408-4411 NN denotes MDM
T11185 4412-4413 -LRB- denotes (
T11186 4413-4419 NN denotes Figure
T11187 4420-4422 NN denotes 7E
T11188 4422-4423 -RRB- denotes )
T11189 4424-4425 -LRB- denotes (
T11190 4425-4434 NN denotes p = 0.012
T11191 4434-4435 -RRB- denotes )
T11192 4436-4439 CC denotes and
T11193 4440-4443 NN denotes Raw
T11194 4444-4449 CD denotes 264.7
T11195 4450-4455 NN denotes cells
T11196 4456-4457 -LRB- denotes (
T11197 4457-4463 NN denotes Figure
T11198 4464-4466 NN denotes 7F
T11199 4466-4467 -RRB- denotes )
T11200 4468-4469 -LRB- denotes (
T11201 4469-4477 NN denotes p = 0.01
T11202 4477-4478 -RRB- denotes )
T11203 4480-4482 PRP denotes We
T11204 4483-4487 RB denotes also
T11205 4488-4496 VB denotes examined
T11206 4497-4501 NN denotes cell
T11207 4502-4510 NN denotes survival
T11208 4511-4513 IN denotes of
T11209 4514-4517 DT denotes the
T11210 4518-4522 NN denotes MDMs
T11211 4523-4525 IN denotes by
T11212 4526-4533 NN denotes Annexin
T11213 4534-4540 NN denotes V-FITC
T11214 4541-4544 CC denotes and
T11215 4545-4547 NN denotes PI
T11216 4548-4556 NN denotes staining
T11217 4557-4562 IN denotes after
T11218 4563-4567 NN denotes PKCα
T11219 4568-4573 NN denotes siRNA
T11220 4574-4586 NN denotes transfection
T11221 4588-4590 IN denotes As
T11222 4591-4596 VB denotes shown
T11223 4597-4599 IN denotes in
T11224 4600-4606 NNP denotes Figure
T11225 4607-4609 NNP denotes 7G
T11226 4609-4610 -COMMA- denotes ,
T11227 4611-4624 JJ denotes M-CSF-induced
T11228 4625-4628 NN denotes MDM
T11229 4629-4637 NN denotes survival
T11230 4638-4641 VB denotes was
T11231 4642-4649 VB denotes reduced
T11232 4650-4652 IN denotes in
T11233 4653-4656 DT denotes the
T11234 4657-4662 NN denotes cells
T11235 4663-4674 VB denotes transfected
T11236 4675-4679 IN denotes with
T11237 4680-4684 NN denotes PKCα
T11238 4685-4690 NN denotes siRNA
T11239 4691-4699 VB denotes compared
T11240 4700-4704 IN denotes with
T11241 4705-4710 NN denotes cells
T11242 4711-4722 VB denotes transfected
T11243 4723-4727 IN denotes with
T11244 4728-4735 NN denotes control
T11245 4736-4741 NN denotes siRNA
T11246 4742-4743 -LRB- denotes (
T11247 4743-4752 NN denotes p = 0.047
T11248 4752-4753 -RRB- denotes )
T11249 4755-4757 IN denotes In
T11250 4758-4764 NN denotes Figure
T11251 4765-4767 NN denotes 7H
T11252 4767-4768 -COMMA- denotes ,
T11253 4769-4771 PRP denotes we
T11254 4772-4781 VB denotes confirmed
T11255 4782-4786 IN denotes that
T11256 4787-4791 NN denotes PKCα
T11257 4792-4797 NN denotes siRNA
T11258 4798-4810 NN denotes transfection
T11259 4811-4820 VB denotes decreased
T11260 4821-4825 NN denotes PKCα
T11261 4826-4833 NN denotes protein
T11262 4834-4844 NN denotes expression
T11263 4845-4847 IN denotes in
T11264 4848-4852 CC denotes both
T11265 4853-4856 NN denotes MDM
T11266 4857-4860 CC denotes and
T11267 4861-4864 NN denotes Raw
T11268 4865-4870 CD denotes 264.7
T11269 4871-4876 NN denotes cells
T11270 4878-4881 PRP-DOLLAR- denotes Our
T11271 4882-4889 NN denotes results
T11272 4890-4899 VB denotes indicated
T11273 4900-4904 IN denotes that
T11274 4905-4909 NN denotes PKCα
T11275 4910-4919 VB denotes regulated
T11276 4920-4925 NN denotes NF-κB
T11277 4926-4936 NN denotes activation
T11278 4937-4940 CC denotes and
T11279 4941-4956 JJ denotes M-CSF-regulated
T11280 4957-4961 NN denotes cell
T11281 4962-4970 NN denotes survival
T25799 1347-1351 NN denotes PKCα
T25800 1352-1361 VB denotes regulates
T25801 1362-1377 NN denotes phosphorylation
T25802 1378-1380 IN denotes of
T25803 1381-1386 NN denotes NF-κB
T25804 1387-1390 NN denotes p65
T25805 1391-1393 IN denotes at
T25806 1394-1400 NN denotes Ser276
T25807 1402-1403 -LRB- denotes (
T25808 1403-1404 NN denotes A
T25809 1404-1405 -RRB- denotes )
T25810 1406-1409 NN denotes MDM
T25811 1410-1412 CC denotes or
T25812 1413-1414 -LRB- denotes (
T25813 1414-1415 NN denotes B
T25814 1415-1416 -RRB- denotes )
T25815 1417-1420 NN denotes RAW
T25816 1421-1426 CD denotes 264.7
T25817 1427-1432 NN denotes cells
T25818 1433-1437 VB denotes were
T25819 1438-1449 RB denotes transiently
T25820 1450-1461 VB denotes transfected
T25821 1462-1466 IN denotes with
T25822 1467-1478 NN denotes pNF-κB-SEAP
T25823 1479-1484 IN denotes along
T25824 1485-1489 IN denotes with
T25825 1490-1496 CC denotes either
T25826 1497-1504 JJ denotes WT-PKCα
T25827 1505-1507 CC denotes or
T25828 1508-1511 DT denotes the
T25829 1512-1528 JJ denotes kinase-deficient
T25830 1529-1530 -LRB- denotes (
T25831 1530-1532 NN denotes KD
T25832 1532-1533 -RRB- denotes )
T25833 1533-1538 NN denotes -PKCα
T25834 1539-1548 NN denotes construct
T25835 1549-1551 IN denotes at
T25836 1552-1553 DT denotes a
T25837 1554-1557 CD denotes 1∶5
T25838 1558-1563 NN denotes ratio
T25839 1565-1570 NN denotes Cells
T25840 1571-1575 VB denotes were
T25841 1576-1581 NN denotes serum
T25842 1582-1589 VB denotes starved
T25843 1590-1593 CC denotes and
T25844 1594-1604 VB denotes stimulated
T25845 1605-1609 IN denotes with
T25846 1610-1615 NN denotes M-CSF
T25847 1616-1619 CC denotes and
T25848 1620-1624 RB denotes then
T25849 1625-1629 NN denotes SEAP
T25850 1630-1639 NN denotes secretion
T25851 1640-1642 IN denotes in
T25852 1643-1646 DT denotes the
T25853 1647-1653 NN denotes medium
T25854 1654-1657 VB denotes was
T25855 1658-1666 VB denotes measured
T25856 1668-1672 NN denotes Data
T25857 1673-1675 VB denotes is
T25858 1676-1680 IN denotes from
T25859 1681-1683 IN denotes of
T25860 1684-1689 CD denotes three
T25861 1690-1701 JJ denotes independent
T25862 1702-1713 NN denotes experiments
T25863 1715-1718 DT denotes The
T25864 1719-1726 NN denotes p-value
T25865 1727-1729 IN denotes of
T25866 1730-1735 NN denotes cells
T25867 1736-1747 VB denotes transfected
T25868 1748-1752 IN denotes with
T25869 1753-1755 NN denotes KD
T25870 1756-1764 VB denotes compared
T25871 1765-1767 TO denotes to
T25872 1768-1773 DT denotes those
T25873 1774-1785 VB denotes transfected
T25874 1786-1790 IN denotes with
T25875 1791-1793 NN denotes WT
T25876 1794-1797 VB denotes was
T25877 1798-1803 CD denotes 0.05.
T25878 1804-1805 -LRB- denotes (
T25879 1805-1806 NN denotes C
T25880 1806-1807 -RRB- denotes )
T25881 1808-1812 NN denotes MDMs
T25882 1813-1817 VB denotes were
T25883 1818-1825 VB denotes removed
T25884 1826-1830 IN denotes from
T25885 1831-1834 DT denotes the
T25886 1835-1840 NN denotes plate
T25887 1841-1846 VB denotes using
T25888 1847-1855 NN denotes accutase
T25889 1856-1859 CC denotes and
T25890 1860-1869 NN denotes apoptosis
T25891 1870-1872 IN denotes of
T25892 1873-1877 NN denotes MDMs
T25893 1878-1881 VB denotes was
T25894 1882-1890 VB denotes measured
T25895 1891-1893 IN denotes by
T25896 1894-1898 NN denotes flow
T25897 1899-1908 NN denotes cytometry
T25898 1909-1914 VB denotes using
T25899 1915-1922 NN denotes Annexin
T25900 1923-1929 NN denotes V-FITC
T25901 1930-1933 CC denotes and
T25902 1934-1943 NN denotes propidium
T25903 1944-1950 NN denotes iodine
T25904 1951-1952 -LRB- denotes (
T25905 1952-1954 NN denotes PI
T25906 1954-1955 -RRB- denotes )
T25907 1955-1956 -LRB- denotes .
T25908 1957-1958 NN denotes (
T25909 1958-1959 -RRB- denotes D
T25910 1959-1964 JJ denotes ) Who
T25911 1964-1968 NN denotes le c
T25912 1968-1975 NN denotes ell lys
T25913 1975-1979 IN denotes ates
T25914 1980-1983 DT denotes fro
T25915 1983-1994 VB denotes m the trans
T25916 1994-1997 NN denotes fec
T25917 1997-2002 CD denotes ted R
T25918 2002-2007 NN denotes AW 26
T25919 2007-2011 VB denotes 4.7
T25920 2011-2020 VB denotes cells wer
T25921 2020-2022 TO denotes e
T25922 2022-2029 JJ denotes subject
T25923 2029-2033 NN denotes ed t
T25924 2033-2041 NN denotes o Wester
T25925 2041-2045 IN denotes n bl
T25926 2045-2059 NN denotes ot analysis wi
T25927 2059-2061 CC denotes th
T25928 2062-2076 NN denotes phospho-Ser276
T25929 2077-2082 NN denotes or ph
T25930 2082-2085 NN denotes osp
T25931 2085-2095 NN denotes ho-Ser536
T25932 2117-2122 NN denotes Blots
T25933 2123-2127 VB denotes were
T25934 2128-2141 VB denotes immunoblotted
T25935 2142-2146 IN denotes with
T25936 2147-2151 NN denotes PKCα
T25937 2152-2154 TO denotes to
T25938 2155-2164 VB denotes determine
T25939 2165-2170 JJ denotes equal
T25940 2171-2178 NN denotes protein
T25941 2179-2189 NN denotes expression
T25942 2190-2193 IN denotes for
T25943 2194-2197 DT denotes the
T25944 2198-2202 NN denotes PKCα
T25945 2203-2214 NN denotes constructs.
T25946 2215-2222 NN denotes β-actin
T25947 2223-2229 VB denotes served
T25948 2230-2232 IN denotes as
T25949 2233-2234 DT denotes a
T25950 2235-2242 NN denotes loading
T25951 2243-2250 NN denotes control
T25952 2252-2257 NNP denotes Shown
T25953 2258-2260 VB denotes is
T25954 2261-2262 DT denotes a
T25955 2263-2277 JJ denotes representative
T25956 2278-2282 NN denotes blot
T25957 2283-2287 IN denotes from
T25958 2288-2293 CD denotes three
T25959 2294-2305 JJ denotes independent
T25960 2306-2318 NN denotes experiments.
T25961 2319-2320 -LRB- denotes (
T25962 2320-2321 NN denotes E
T25963 2321-2322 -RRB- denotes )
T25964 2323-2326 NN denotes MDM
T25965 2327-2329 CC denotes or
T25966 2330-2331 -LRB- denotes (
T25967 2331-2332 NN denotes F
T25968 2332-2333 -RRB- denotes )
T25969 2334-2337 NN denotes RAW
T25970 2338-2343 CD denotes 264.7
T25971 2344-2349 NN denotes cells
T25972 2350-2354 VB denotes were
T25973 2355-2366 RB denotes transiently
T25974 2367-2378 VB denotes transfected
T25975 2379-2383 IN denotes with
T25976 2384-2385 DT denotes a
T25977 2386-2397 NN denotes pNF-κB-SEAP
T25978 2398-2403 IN denotes along
T25979 2404-2408 IN denotes with
T25980 2409-2415 CC denotes either
T25981 2416-2419 CD denotes 100
T25982 2420-2422 NN denotes nM
T25983 2423-2427 NN denotes PKCα
T25984 2428-2433 NN denotes siRNA
T25985 2434-2436 CC denotes or
T25986 2437-2444 NN denotes control
T25987 2445-2450 NN denotes siRNA
T25988 2451-2454 IN denotes for
T25989 2455-2460 CD denotes 20-24
T25990 2461-2466 NN denotes hours
T25991 2468-2473 NN denotes Cells
T25992 2474-2478 VB denotes were
T25993 2479-2484 NN denotes serum
T25994 2485-2492 VB denotes starved
T25995 2493-2496 IN denotes for
T25996 2497-2500 CD denotes 2-4
T25997 2501-2506 NN denotes hours
T25998 2507-2510 CC denotes and
T25999 2511-2521 VB denotes stimulated
T26000 2522-2526 IN denotes with
T26001 2527-2530 CD denotes 100
T26002 2531-2536 NN denotes ng/ml
T26003 2537-2542 NN denotes M-CSF
T26004 2543-2546 IN denotes for
T26005 2547-2548 CD denotes 6
T26006 2549-2554 NN denotes hours
T26007 2555-2558 IN denotes for
T26008 2559-2562 NN denotes MDM
T26009 2563-2565 CC denotes or
T26010 2566-2569 NN denotes RAW
T26011 2570-2575 CD denotes 264.7
T26012 2576-2579 IN denotes for
T26013 2580-2581 CD denotes 2
T26014 2582-2587 NN denotes hours
T26015 2588-2591 CC denotes and
T26016 2592-2596 RB denotes then
T26017 2597-2601 NN denotes SEAP
T26018 2602-2611 NN denotes secretion
T26019 2612-2614 IN denotes in
T26020 2615-2618 DT denotes the
T26021 2619-2625 NN denotes medium
T26022 2626-2629 VB denotes was
T26023 2630-2638 VB denotes measured
T26024 2640-2645 NNP denotes Shown
T26025 2646-2648 VB denotes is
T26026 2649-2653 NN denotes data
T26027 2654-2656 IN denotes of
T26028 2657-2662 CD denotes three
T26029 2663-2674 JJ denotes independent
T26030 2675-2687 NN denotes experiments.
T26031 2688-2689 -LRB- denotes (
T26032 2689-2690 NN denotes G
T26033 2690-2691 -RRB- denotes )
T26034 2692-2696 NN denotes MDMs
T26035 2697-2701 VB denotes were
T26036 2702-2709 VB denotes removed
T26037 2710-2714 IN denotes from
T26038 2715-2718 DT denotes the
T26039 2719-2724 NN denotes plate
T26040 2725-2730 VB denotes using
T26041 2731-2739 NN denotes accutase
T26042 2740-2743 CC denotes and
T26043 2744-2753 NN denotes apoptosis
T26044 2754-2756 IN denotes of
T26045 2757-2761 NN denotes MDMs
T26046 2762-2765 VB denotes was
T26047 2766-2774 VB denotes measured
T26048 2775-2777 IN denotes by
T26049 2778-2785 NN denotes Annexin
T26050 2786-2792 NN denotes V-FITC
T26051 2793-2796 CC denotes and
T26052 2797-2806 NN denotes propidium
T26053 2807-2813 NN denotes iodine
T26054 2814-2815 -LRB- denotes (
T26055 2815-2817 NN denotes PI
T26056 2817-2818 -RRB- denotes )
T26057 2819-2827 NN denotes staining
T26058 2828-2831 CC denotes and
T26059 2832-2840 VB denotes analyzed
T26060 2841-2843 IN denotes by
T26061 2844-2848 NN denotes flow
T26062 2849-2859 NN denotes cytometry.
T26063 2860-2861 -LRB- denotes (
T26064 2861-2862 NN denotes H
T26065 2862-2863 -RRB- denotes )
T26066 2864-2869 JJ denotes Whole
T26067 2870-2874 NN denotes cell
T26068 2875-2882 NN denotes lysates
T26069 2883-2887 IN denotes from
T26070 2888-2891 DT denotes the
T26071 2892-2903 VB denotes transfected
T26072 2904-2907 NN denotes MDM
T26073 2908-2911 CC denotes and
T26074 2912-2915 NN denotes RAW
T26075 2916-2921 CD denotes 264.7
T26076 2922-2927 NN denotes cells
T26077 2928-2932 VB denotes were
T26078 2933-2942 VB denotes subjected
T26079 2943-2945 TO denotes to
T26080 2946-2953 JJ denotes Western
T26081 2954-2958 NN denotes blot
T26082 2959-2967 NN denotes analysis
T26083 2968-2972 IN denotes with
T26084 2973-2977 NN denotes PKCα
T26085 2978-2987 NN denotes antibody.
T26086 2988-2995 NN denotes β-actin
T26087 2996-3002 VB denotes served
T26088 3003-3005 IN denotes as
T26089 3006-3007 DT denotes a
T26090 3008-3015 NN denotes loading
T26091 3016-3023 NN denotes control
T26092 3025-3030 NNP denotes Shown
T26093 3031-3033 VB denotes is
T26094 3034-3035 DT denotes a
T26095 3036-3050 JJ denotes representative
T26096 3051-3055 NN denotes blot
T26097 3056-3060 IN denotes from
T26098 3061-3063 IN denotes at
T26099 3064-3069 JJ denotes least
T26100 3070-3075 CD denotes three
T26101 3076-3087 JJ denotes independent
T26102 3088-3099 NN denotes experiments
R8166 T10779 T10780 arg1Of Identification,of
R8167 T10779 T10782 arg1Of Identification,as
R8168 T10781 T10780 arg2Of PKCα,of
R8169 T10785 T10782 arg2Of Activator,as
R8170 T10785 T10783 arg1Of Activator,the
R8171 T10785 T10784 arg1Of Activator,Upstream
R8172 T10785 T10786 arg1Of Activator,of
R8173 T10785 T10788 arg1Of Activator,in
R8174 T10787 T10786 arg2Of NF-κB,of
R8175 T10790 T10788 arg2Of Cells,in
R8176 T10790 T10789 arg1Of Cells,Myeloid
R8177 T10792 T10791 arg1Of though,Even
R8178 T10795 T10793 arg1Of family,the
R8179 T10795 T10794 arg1Of family,PKC
R8180 T10795 T10796 arg1Of family,consists
R8181 T10795 T10801 arg1Of family,finding
R8182 T10796 T10792 arg2Of consists,though
R8183 T10796 T10797 arg1Of consists,of
R8184 T10796 T10800 arg1Of consists,","
R8185 T10796 T10801 modOf consists,finding
R8186 T10799 T10797 arg2Of members,of
R8187 T10799 T10798 arg1Of members,10
R8188 T10804 T10803 arg1Of inhibitors,PKCα/β
R8189 T10804 T10805 arg1Of inhibitors,and
R8190 T10805 T10809 arg1Of and,reduced
R8191 T10808 T10805 arg2Of inhibitors,and
R8192 T10808 T10806 arg1Of inhibitors,intracellular
R8193 T10808 T10807 arg1Of inhibitors,calcium
R8194 T10809 T10802 arg1Of reduced,that
R8195 T10809 T10814 arg1Of reduced,suggested
R8196 T10812 T10809 arg2Of activity,reduced
R8197 T10812 T10810 arg1Of activity,M-CSF-induced
R8198 T10812 T10811 arg1Of activity,NF-κB
R8199 T10814 T10792 arg1Of suggested,though
R8200 T10814 T10813 arg1Of suggested,","
R8201 T10815 T10816 arg1Of PKCα,was
R8202 T10815 T10817 arg2Of PKCα,involved
R8203 T10817 T10814 arg2Of involved,suggested
R8204 T10817 T10816 arg2Of involved,was
R8205 T10817 T10818 arg1Of involved,in
R8206 T10817 T10821 arg1Of involved,after
R8207 T10820 T10818 arg2Of activation,in
R8208 T10820 T10819 arg1Of activation,NF-κB
R8209 T10823 T10821 arg2Of treatment,after
R8210 T10823 T10822 arg1Of treatment,M-CSF
R8211 T10825 T10824 arg1Of confirm,To
R8212 T10827 T10825 arg2Of role,confirm
R8213 T10827 T10826 arg1Of role,the
R8214 T10827 T10828 arg1Of role,of
R8215 T10827 T10830 arg1Of role,in
R8216 T10829 T10828 arg2Of PKCα,of
R8217 T10832 T10830 arg2Of activation,in
R8218 T10832 T10831 arg1Of activation,NF-κB
R8219 T10832 T10833 arg1Of activation,in
R8220 T10834 T10833 arg2Of macrophages,in
R8221 T10836 T10837 arg1Of constructs,for
R8222 T10836 T10850 arg1Of constructs,was
R8223 T10836 T10851 arg2Of constructs,co-transfected
R8224 T10841 T10840 arg2Of WT,(
R8225 T10842 T10840 arg3Of ),(
R8226 T10843 T10839 arg1Of -PKCα,wildtype
R8227 T10843 T10840 arg1Of -PKCα,(
R8228 T10843 T10844 arg1Of -PKCα,or
R8229 T10844 T10837 arg2Of or,for
R8230 T10844 T10838 arg1Of or,either
R8231 T10847 T10846 arg2Of KD,(
R8232 T10848 T10846 arg3Of ),(
R8233 T10849 T10844 arg2Of -PKCα,or
R8234 T10849 T10845 arg1Of -PKCα,kinase-deficient
R8235 T10849 T10846 arg1Of -PKCα,(
R8236 T10851 T10850 arg2Of co-transfected,was
R8237 T10851 T10852 arg1Of co-transfected,with
R8238 T10851 T10857 arg1Of co-transfected,and
R8239 T10856 T10852 arg2Of gene,with
R8240 T10856 T10853 arg1Of gene,the
R8241 T10856 T10854 arg1Of gene,pNF-κB-SEAP
R8242 T10856 T10855 arg1Of gene,reporter
R8243 T10857 T10824 modOf and,To
R8244 T10857 T10835 arg1Of and,","
R8245 T10859 T10858 arg1Of secretion,SEAP
R8246 T10859 T10860 arg1Of secretion,was
R8247 T10859 T10861 arg2Of secretion,measured
R8248 T10861 T10857 arg2Of measured,and
R8249 T10861 T10860 arg2Of measured,was
R8250 T10863 T10862 arg2Of shown,As
R8251 T10863 T10864 arg1Of shown,in
R8252 T10866 T10864 arg2Of 7A,in
R8253 T10866 T10865 arg1Of 7A,Figure
R8254 T10868 T10869 arg2Of MDMs,co-transfected
R8255 T10868 T10874 arg1Of MDMs,had
R8256 T10869 T10870 arg1Of co-transfected,with
R8257 T10871 T10872 arg1Of pNF-κB-SEAP,and
R8258 T10872 T10870 arg2Of and,with
R8259 T10873 T10872 arg2Of WT-PKCα,and
R8260 T10874 T10862 arg1Of had,As
R8261 T10874 T10867 arg1Of had,","
R8262 T10874 T10882 arg1Of had,after
R8263 T10877 T10874 arg2Of increase,had
R8264 T10877 T10875 arg1Of increase,a
R8265 T10877 T10876 arg1Of increase,1.8-fold
R8266 T10877 T10878 arg1Of increase,in
R8267 T10881 T10878 arg2Of activity,in
R8268 T10881 T10879 arg1Of activity,NF-κB
R8269 T10881 T10880 arg1Of activity,transcriptional
R8270 T10884 T10882 arg2Of activation,after
R8271 T10884 T10883 arg1Of activation,M-CSF
R8272 T10884 T10885 arg1Of activation,compared
R8273 T10886 T10885 arg2Of with,compared
R8274 T10888 T10886 arg2Of cells,with
R8275 T10888 T10887 arg1Of cells,NS
R8276 T10888 T10889 arg1Of cells,(
R8277 T10888 T10892 arg1Of cells,","
R8278 T10888 T10893 arg1Of cells,similar
R8279 T10890 T10889 arg2Of p = 0.05,(
R8280 T10891 T10889 arg3Of ),(
R8281 T10893 T10894 arg1Of similar,to
R8282 T10896 T10894 arg2Of cells,to
R8283 T10896 T10895 arg1Of cells,M-CSF-treated
R8284 T10896 T10897 arg1Of cells,expressing
R8285 T10899 T10897 arg2Of pNF-κB-SEAP,expressing
R8286 T10899 T10898 arg1Of pNF-κB-SEAP,only
R8287 T10900 T10903 arg1Of Transfecting,with
R8288 T10900 T10908 arg1Of Transfecting,reduced
R8289 T10902 T10900 arg2Of macrophages,Transfecting
R8290 T10902 T10901 arg1Of macrophages,human
R8291 T10906 T10903 arg2Of construct,with
R8292 T10906 T10904 arg1Of construct,the
R8293 T10906 T10905 arg1Of construct,KD-PKCα
R8294 T10908 T10907 arg1Of reduced,significantly
R8295 T10908 T10912 arg1Of reduced,compared
R8296 T10911 T10908 arg2Of activity,reduced
R8297 T10911 T10909 arg1Of activity,M-CSF-induced
R8298 T10911 T10910 arg1Of activity,NF-κB
R8299 T10913 T10912 arg2Of to,compared
R8300 T10916 T10913 arg2Of cells,to
R8301 T10916 T10914 arg1Of cells,WT-PKCα
R8302 T10916 T10915 arg2Of cells,transfected
R8303 T10916 T10917 arg1Of cells,(
R8304 T10918 T10917 arg2Of p = 0.016,(
R8305 T10919 T10917 arg3Of ),(
R8306 T10924 T10922 arg1Of cells,RAW
R8307 T10924 T10923 arg1Of cells,264.7
R8308 T10924 T10925 arg2Of cells,transfected
R8309 T10924 T10928 arg1Of cells,had
R8310 T10925 T10926 arg1Of transfected,with
R8311 T10927 T10926 arg2Of WT-PKCα,with
R8312 T10928 T10920 arg1Of had,Similarly
R8313 T10928 T10921 arg1Of had,","
R8314 T10928 T10934 arg1Of had,after
R8315 T10928 T10937 arg1Of had,compared
R8316 T10930 T10929 arg1Of more,2.5-fold
R8317 T10933 T10928 arg2Of activity,had
R8318 T10933 T10930 arg1Of activity,more
R8319 T10933 T10931 arg1Of activity,NF-κB
R8320 T10933 T10932 arg1Of activity,transcriptional
R8321 T10936 T10934 arg2Of activation,after
R8322 T10936 T10935 arg1Of activation,M-CSF
R8323 T10938 T10937 arg2Of to,compared
R8324 T10942 T10938 arg2Of cells,to
R8325 T10942 T10939 arg1Of cells,unstimulated
R8326 T10942 T10940 arg1Of cells,RAW
R8327 T10942 T10941 arg1Of cells,264.7
R8328 T10942 T10943 arg1Of cells,(
R8329 T10942 T10946 arg2Of cells,transfected
R8330 T10944 T10943 arg2Of NS,(
R8331 T10945 T10943 arg3Of ),(
R8332 T10946 T10947 arg1Of transfected,with
R8333 T10948 T10947 arg2Of WT-PKCα,with
R8334 T10948 T10949 arg1Of WT-PKCα,(
R8335 T10951 T10949 arg2Of 7B,(
R8336 T10951 T10950 arg1Of 7B,Figure
R8337 T10952 T10949 arg3Of ),(
R8338 T10953 T10954 arg1Of Expression,of
R8339 T10953 T10958 arg1Of Expression,into
R8340 T10953 T10962 arg1Of Expression,reduced
R8341 T10957 T10954 arg2Of construct,of
R8342 T10957 T10955 arg1Of construct,the
R8343 T10957 T10956 arg1Of construct,KD-PKCα
R8344 T10961 T10958 arg2Of cells,into
R8345 T10961 T10959 arg1Of cells,RAW
R8346 T10961 T10960 arg1Of cells,264.7
R8347 T10962 T10966 arg1Of reduced,to
R8348 T10962 T10971 arg1Of reduced,compared
R8349 T10965 T10962 arg2Of activity,reduced
R8350 T10965 T10963 arg1Of activity,M-CSF-induced
R8351 T10965 T10964 arg1Of activity,NF-κB
R8352 T10967 T10966 arg2Of 1.5-fold,to
R8353 T10967 T10968 arg1Of 1.5-fold,(
R8354 T10969 T10968 arg2Of p = 0.045,(
R8355 T10970 T10968 arg3Of ),(
R8356 T10972 T10971 arg2Of to,compared
R8357 T10973 T10972 arg2Of cells,to
R8358 T10973 T10974 arg2Of cells,transfected
R8359 T10974 T10975 arg1Of transfected,with
R8360 T10977 T10975 arg2Of PKCα,with
R8361 T10977 T10976 arg1Of PKCα,WT
R8362 T10979 T10978 arg1Of survival,Cell
R8363 T10979 T10980 arg1Of survival,was
R8364 T10979 T10982 arg2Of survival,examined
R8365 T10982 T10980 arg2Of examined,was
R8366 T10982 T10981 arg1Of examined,also
R8367 T10982 T10983 arg1Of examined,in
R8368 T10984 T10983 arg2Of MDMs,in
R8369 T10984 T10985 arg1Of MDMs,expressing
R8370 T10985 T10991 arg1Of expressing,by
R8371 T10987 T10988 arg1Of WT-PKCα,or
R8372 T10988 T10986 arg1Of or,either
R8373 T10989 T10988 arg2Of KD-PKCα,or
R8374 T10990 T10985 arg2Of constructs,expressing
R8375 T10990 T10987 arg1Of constructs,WT-PKCα
R8376 T10990 T10989 arg1Of constructs,KD-PKCα
R8377 T10993 T10992 arg1Of V-FITC,Annexin
R8378 T10993 T10994 arg1Of V-FITC,and
R8379 T10994 T10991 arg2Of and,by
R8380 T10996 T10994 arg2Of staining,and
R8381 T10996 T10995 arg1Of staining,PI
R8382 T10998 T10997 arg2Of expected,As
R8383 T11000 T11001 arg1Of M-CSF,increased
R8384 T11001 T10997 arg1Of increased,As
R8385 T11001 T10999 arg1Of increased,","
R8386 T11003 T11001 arg2Of survival,increased
R8387 T11003 T11002 arg1Of survival,MDM
R8388 T11004 T11001 arg3Of as,increased
R8389 T11005 T11004 arg2Of measured,as
R8390 T11005 T11006 arg1Of measured,by
R8391 T11008 T11006 arg2Of percent,by
R8392 T11008 T11007 arg1Of percent,the
R8393 T11008 T11009 arg1Of percent,of
R8394 T11013 T11009 arg2Of cells,of
R8395 T11013 T11010 arg1Of cells,Annexin
R8396 T11013 T11011 arg1Of cells,V/PI
R8397 T11013 T11012 arg1Of cells,negative
R8398 T11016 T11015 arg1Of expression,","
R8399 T11016 T11017 arg1Of expression,of
R8400 T11016 T11021 arg1Of expression,from
R8401 T11020 T11017 arg2Of cells,of
R8402 T11020 T11018 arg1Of cells,WT-PKCα
R8403 T11020 T11019 arg1Of cells,protected
R8404 T11021 T11014 arg1Of from,Similarly
R8405 T11022 T11021 arg2Of apoptosis,from
R8406 T11024 T11023 arg2Of contrast,In
R8407 T11026 T11027 arg1Of expression,of
R8408 T11026 T11029 arg1Of expression,decreased
R8409 T11028 T11027 arg2Of KD-PKCα,of
R8410 T11029 T11023 arg1Of decreased,In
R8411 T11029 T11025 arg1Of decreased,","
R8412 T11032 T11029 arg2Of survival,decreased
R8413 T11032 T11030 arg1Of survival,M-CSF-induced
R8414 T11032 T11031 arg1Of survival,cell
R8415 T11032 T11033 arg1Of survival,(
R8416 T11032 T11038 arg1Of survival,(
R8417 T11034 T11033 arg2Of p,(
R8418 T11034 T11035 arg1Of p,<
R8419 T11034 T11036 arg1Of p,0.01
R8420 T11037 T11033 arg3Of ),(
R8421 T11040 T11038 arg2Of 7C,(
R8422 T11040 T11039 arg1Of 7C,Figure
R8423 T11041 T11038 arg3Of ),(
R8424 T11044 T11045 arg1Of we,examined
R8425 T11045 T11042 arg1Of examined,Next
R8426 T11045 T11043 arg1Of examined,","
R8427 T11047 T11045 arg2Of effect,examined
R8428 T11047 T11046 arg1Of effect,the
R8429 T11047 T11048 arg1Of effect,of
R8430 T11049 T11048 arg2Of expressing,of
R8431 T11052 T11049 arg2Of constructs,expressing
R8432 T11052 T11050 arg1Of constructs,the
R8433 T11052 T11051 arg1Of constructs,PKCα
R8434 T11052 T11053 arg1Of constructs,on
R8435 T11055 T11053 arg2Of phosphorylation,on
R8436 T11055 T11054 arg1Of phosphorylation,NF-κB
R8437 T11057 T11056 arg2Of shown,As
R8438 T11057 T11058 arg1Of shown,in
R8439 T11060 T11058 arg2Of 7D,in
R8440 T11060 T11059 arg1Of 7D,Figure
R8441 T11062 T11063 arg1Of expression,of
R8442 T11062 T11065 arg1Of expression,in
R8443 T11062 T11069 arg1Of expression,did
R8444 T11062 T11071 arg1Of expression,affect
R8445 T11062 T11082 arg1Of expression,attenuated
R8446 T11064 T11063 arg2Of KD-PKCα,of
R8447 T11068 T11065 arg2Of cells,in
R8448 T11068 T11066 arg1Of cells,RAW
R8449 T11068 T11067 arg1Of cells,264.7
R8450 T11071 T11069 arg2Of affect,did
R8451 T11071 T11070 arg1Of affect,not
R8452 T11071 T11081 arg1Of affect,but
R8453 T11074 T11071 arg2Of phosphorylation,affect
R8454 T11074 T11072 arg1Of phosphorylation,the
R8455 T11074 T11073 arg1Of phosphorylation,constitutive
R8456 T11074 T11075 arg1Of phosphorylation,at
R8457 T11076 T11075 arg2Of Ser536,at
R8458 T11076 T11077 arg1Of Ser536,of
R8459 T11079 T11077 arg2Of p65,of
R8460 T11079 T11078 arg1Of p65,NF-κB
R8461 T11081 T11056 arg1Of but,As
R8462 T11081 T11061 arg1Of but,","
R8463 T11081 T11080 arg1Of but,","
R8464 T11082 T11081 arg2Of attenuated,but
R8465 T11082 T11085 arg1Of attenuated,at
R8466 T11084 T11082 arg2Of phosphorylation,attenuated
R8467 T11084 T11083 arg1Of phosphorylation,the
R8468 T11086 T11085 arg2Of Ser276,at
R8469 T11087 T11088 arg1Of Expression,of
R8470 T11087 T11090 arg1Of Expression,did
R8471 T11087 T11092 arg1Of Expression,effect
R8472 T11089 T11088 arg2Of WT-PKCα,of
R8473 T11092 T11090 arg2Of effect,did
R8474 T11092 T11091 arg1Of effect,not
R8475 T11094 T11092 arg2Of phosphorylation,effect
R8476 T11094 T11093 arg1Of phosphorylation,the
R8477 T11094 T11095 arg1Of phosphorylation,of
R8478 T11097 T11095 arg2Of residue,of
R8479 T11097 T11096 arg1Of residue,either
R8480 T11097 T11098 arg1Of residue,with
R8481 T11097 T11100 arg1Of residue,without
R8482 T11098 T11099 arg1Of with,or
R8483 T11100 T11099 arg2Of without,or
R8484 T11102 T11098 arg2Of stimulation,with
R8485 T11102 T11100 arg2Of stimulation,without
R8486 T11102 T11101 arg1Of stimulation,M-CSF
R8487 T11104 T11103 arg1Of observations,These
R8488 T11104 T11105 arg1Of observations,demonstrate
R8489 T11107 T11108 arg1Of PKCα,is
R8490 T11107 T11109 arg1Of PKCα,important
R8491 T11108 T11105 arg2Of is,demonstrate
R8492 T11108 T11106 arg1Of is,that
R8493 T11109 T11108 arg2Of important,is
R8494 T11109 T11110 arg1Of important,in
R8495 T11113 T11111 arg1Of survival,M-CSF-regulated
R8496 T11113 T11112 arg1Of survival,cell
R8497 T11113 T11114 arg1Of survival,and
R8498 T11114 T11110 arg2Of and,in
R8499 T11114 T11119 arg2Of and,regulated
R8500 T11116 T11114 arg2Of activation,and
R8501 T11116 T11115 arg1Of activation,NF-κB
R8502 T11119 T11117 arg1Of regulated,and
R8503 T11119 T11118 arg1Of regulated,likely
R8504 T11119 T11120 arg1Of regulated,through
R8505 T11121 T11120 arg2Of phosphorylation,through
R8506 T11121 T11122 arg1Of phosphorylation,of
R8507 T11123 T11122 arg2Of Ser276,of
R8508 T11123 T11124 arg1Of Ser276,of
R8509 T11126 T11124 arg2Of p65,of
R8510 T11126 T11125 arg1Of p65,NF-κB
R8511 T11129 T11127 arg1Of validate,To
R8512 T11129 T11128 arg1Of validate,further
R8513 T11131 T11129 arg2Of impact,validate
R8514 T11131 T11130 arg1Of impact,the
R8515 T11133 T11132 arg1Of PKCα,that
R8516 T11133 T11134 arg2Of PKCα,played
R8517 T11134 T11135 arg1Of played,in
R8518 T11139 T11135 arg2Of activity,in
R8519 T11139 T11136 arg1Of activity,M-CSF-induced
R8520 T11139 T11137 arg1Of activity,NF-κB
R8521 T11139 T11138 arg1Of activity,transcriptional
R8522 T11141 T11129 arg1Of we,validate
R8523 T11141 T11143 arg1Of we,employed
R8524 T11143 T11127 modOf employed,To
R8525 T11143 T11134 modOf employed,played
R8526 T11143 T11140 arg1Of employed,","
R8527 T11143 T11142 arg1Of employed,next
R8528 T11146 T11143 arg2Of treatment,employed
R8529 T11146 T11144 arg1Of treatment,PKCα
R8530 T11146 T11145 arg1Of treatment,siRNA
R8531 T11146 T11147 arg1Of treatment,of
R8532 T11148 T11149 arg1Of MDM,or
R8533 T11150 T11149 arg2Of RAW,or
R8534 T11151 T11147 arg2Of cells,of
R8535 T11151 T11148 arg1Of cells,MDM
R8536 T11151 T11150 arg1Of cells,RAW
R8537 T11153 T11152 arg1Of pool,A
R8538 T11153 T11154 arg1Of pool,of
R8539 T11153 T11158 arg1Of pool,were
R8540 T11153 T11159 arg2Of pool,transfected
R8541 T11157 T11154 arg2Of siRNA,of
R8542 T11157 T11155 arg1Of siRNA,specific
R8543 T11157 T11156 arg1Of siRNA,PKCα
R8544 T11159 T11158 arg2Of transfected,were
R8545 T11159 T11160 arg1Of transfected,into
R8546 T11159 T11166 arg1Of transfected,in
R8547 T11161 T11162 arg1Of MDM,or
R8548 T11162 T11160 arg2Of or,into
R8549 T11165 T11162 arg2Of cells,or
R8550 T11165 T11163 arg1Of cells,Raw
R8551 T11165 T11164 arg1Of cells,264.7
R8552 T11168 T11169 arg1Of presence,or
R8553 T11169 T11166 arg2Of or,in
R8554 T11169 T11167 arg1Of or,the
R8555 T11170 T11171 arg1Of absence,or
R8556 T11171 T11169 arg2Of or,or
R8557 T11172 T11171 arg2Of M-CSF,or
R8558 T11173 T11177 arg1Of Reducing,decreased
R8559 T11176 T11173 arg2Of expression,Reducing
R8560 T11176 T11174 arg1Of expression,native
R8561 T11176 T11175 arg1Of expression,PKCα
R8562 T11181 T11178 arg1Of activity,M-CSF-induced
R8563 T11181 T11179 arg1Of activity,NF-κB
R8564 T11181 T11180 arg1Of activity,transcriptional
R8565 T11181 T11182 arg1Of activity,in
R8566 T11181 T11192 arg1Of activity,and
R8567 T11184 T11182 arg2Of MDM,in
R8568 T11184 T11183 arg1Of MDM,both
R8569 T11184 T11185 arg1Of MDM,(
R8570 T11184 T11189 arg1Of MDM,(
R8571 T11187 T11185 arg2Of 7E,(
R8572 T11187 T11186 arg1Of 7E,Figure
R8573 T11188 T11185 arg3Of ),(
R8574 T11190 T11189 arg2Of p = 0.012,(
R8575 T11191 T11189 arg3Of ),(
R8576 T11192 T11177 arg2Of and,decreased
R8577 T11192 T11200 arg1Of and,(
R8578 T11195 T11192 arg2Of cells,and
R8579 T11195 T11193 arg1Of cells,Raw
R8580 T11195 T11194 arg1Of cells,264.7
R8581 T11195 T11196 arg1Of cells,(
R8582 T11198 T11196 arg2Of 7F,(
R8583 T11198 T11197 arg1Of 7F,Figure
R8584 T11199 T11196 arg3Of ),(
R8585 T11201 T11200 arg2Of p = 0.01,(
R8586 T11202 T11200 arg3Of ),(
R8587 T11203 T11205 arg1Of We,examined
R8588 T11205 T11204 arg1Of examined,also
R8589 T11207 T11205 arg2Of survival,examined
R8590 T11207 T11206 arg1Of survival,cell
R8591 T11207 T11208 arg1Of survival,of
R8592 T11207 T11211 arg1Of survival,by
R8593 T11210 T11208 arg2Of MDMs,of
R8594 T11210 T11209 arg1Of MDMs,the
R8595 T11213 T11212 arg1Of V-FITC,Annexin
R8596 T11213 T11214 arg1Of V-FITC,and
R8597 T11214 T11211 arg2Of and,by
R8598 T11214 T11217 arg1Of and,after
R8599 T11216 T11214 arg2Of staining,and
R8600 T11216 T11215 arg1Of staining,PI
R8601 T11220 T11217 arg2Of transfection,after
R8602 T11220 T11218 arg1Of transfection,PKCα
R8603 T11220 T11219 arg1Of transfection,siRNA
R8604 T11222 T11221 arg2Of shown,As
R8605 T11222 T11223 arg1Of shown,in
R8606 T11225 T11223 arg2Of 7G,in
R8607 T11225 T11224 arg1Of 7G,Figure
R8608 T11229 T11227 arg1Of survival,M-CSF-induced
R8609 T11229 T11228 arg1Of survival,MDM
R8610 T11229 T11230 arg1Of survival,was
R8611 T11229 T11231 arg2Of survival,reduced
R8612 T11231 T11221 arg1Of reduced,As
R8613 T11231 T11226 arg1Of reduced,","
R8614 T11231 T11230 arg2Of reduced,was
R8615 T11231 T11232 arg1Of reduced,in
R8616 T11231 T11239 arg1Of reduced,compared
R8617 T11234 T11232 arg2Of cells,in
R8618 T11234 T11233 arg1Of cells,the
R8619 T11234 T11235 arg2Of cells,transfected
R8620 T11235 T11236 arg1Of transfected,with
R8621 T11238 T11236 arg2Of siRNA,with
R8622 T11238 T11237 arg1Of siRNA,PKCα
R8623 T11240 T11239 arg2Of with,compared
R8624 T11241 T11240 arg2Of cells,with
R8625 T11241 T11242 arg2Of cells,transfected
R8626 T11242 T11243 arg1Of transfected,with
R8627 T11245 T11243 arg2Of siRNA,with
R8628 T11245 T11244 arg1Of siRNA,control
R8629 T11245 T11246 arg1Of siRNA,(
R8630 T11247 T11246 arg2Of p = 0.047,(
R8631 T11248 T11246 arg3Of ),(
R8632 T11251 T11249 arg2Of 7H,In
R8633 T11251 T11250 arg1Of 7H,Figure
R8634 T11253 T11254 arg1Of we,confirmed
R8635 T11254 T11249 arg1Of confirmed,In
R8636 T11254 T11252 arg1Of confirmed,","
R8637 T11258 T11256 arg1Of transfection,PKCα
R8638 T11258 T11257 arg1Of transfection,siRNA
R8639 T11258 T11259 arg1Of transfection,decreased
R8640 T11259 T11254 arg2Of decreased,confirmed
R8641 T11259 T11255 arg1Of decreased,that
R8642 T11259 T11263 arg1Of decreased,in
R8643 T11262 T11259 arg2Of expression,decreased
R8644 T11262 T11260 arg1Of expression,PKCα
R8645 T11262 T11261 arg1Of expression,protein
R8646 T11265 T11266 arg1Of MDM,and
R8647 T11266 T11263 arg2Of and,in
R8648 T11266 T11264 arg1Of and,both
R8649 T11269 T11266 arg2Of cells,and
R8650 T11269 T11267 arg1Of cells,Raw
R8651 T11269 T11268 arg1Of cells,264.7
R8652 T11271 T11270 arg1Of results,Our
R8653 T11271 T11272 arg1Of results,indicated
R8654 T11274 T11275 arg1Of PKCα,regulated
R8655 T11275 T11272 arg2Of regulated,indicated
R8656 T11275 T11273 arg1Of regulated,that
R8657 T11277 T11276 arg1Of activation,NF-κB
R8658 T11277 T11278 arg1Of activation,and
R8659 T11278 T11275 arg2Of and,regulated
R8660 T11281 T11278 arg2Of survival,and
R8661 T11281 T11279 arg1Of survival,M-CSF-regulated
R8662 T11281 T11280 arg1Of survival,cell
R19753 T25799 T25800 arg1Of PKCα,regulates
R19754 T25800 T25805 arg1Of regulates,at
R19755 T25801 T25800 arg2Of phosphorylation,regulates
R19756 T25801 T25802 arg1Of phosphorylation,of
R19757 T25804 T25802 arg2Of p65,of
R19758 T25804 T25803 arg1Of p65,NF-κB
R19759 T25806 T25805 arg2Of Ser276,at
R19760 T25808 T25807 arg2Of A,(
R19761 T25809 T25807 arg3Of ),(
R19762 T25810 T25807 arg1Of MDM,(
R19763 T25810 T25811 arg1Of MDM,or
R19764 T25811 T25818 arg1Of or,were
R19765 T25811 T25820 arg2Of or,transfected
R19766 T25813 T25812 arg2Of B,(
R19767 T25814 T25812 arg3Of ),(
R19768 T25817 T25811 arg2Of cells,or
R19769 T25817 T25812 arg1Of cells,(
R19770 T25817 T25815 arg1Of cells,RAW
R19771 T25817 T25816 arg1Of cells,264.7
R19772 T25820 T25818 arg2Of transfected,were
R19773 T25820 T25819 arg1Of transfected,transiently
R19774 T25820 T25821 arg1Of transfected,with
R19775 T25822 T25821 arg2Of pNF-κB-SEAP,with
R19776 T25822 T25824 arg1Of pNF-κB-SEAP,with
R19777 T25824 T25823 arg1Of with,along
R19778 T25826 T25827 arg1Of WT-PKCα,or
R19779 T25827 T25824 arg2Of or,with
R19780 T25827 T25825 arg1Of or,either
R19781 T25827 T25835 arg1Of or,at
R19782 T25829 T25828 arg1Of kinase-deficient,the
R19783 T25829 T25830 arg1Of kinase-deficient,(
R19784 T25831 T25830 arg2Of KD,(
R19785 T25832 T25830 arg3Of ),(
R19786 T25834 T25827 arg2Of construct,or
R19787 T25834 T25829 arg1Of construct,kinase-deficient
R19788 T25834 T25833 arg1Of construct,-PKCα
R19789 T25838 T25835 arg2Of ratio,at
R19790 T25838 T25836 arg1Of ratio,a
R19791 T25838 T25837 arg1Of ratio,1∶5
R19792 T25839 T25840 arg1Of Cells,were
R19793 T25840 T25847 arg1Of were,and
R19794 T25841 T25840 arg2Of serum,were
R19795 T25841 T25842 arg2Of serum,starved
R19796 T25841 T25844 arg2Of serum,stimulated
R19797 T25842 T25843 arg1Of starved,and
R19798 T25844 T25843 arg2Of stimulated,and
R19799 T25844 T25845 arg1Of stimulated,with
R19800 T25846 T25845 arg2Of M-CSF,with
R19801 T25850 T25849 arg1Of secretion,SEAP
R19802 T25850 T25851 arg1Of secretion,in
R19803 T25850 T25854 arg1Of secretion,was
R19804 T25850 T25855 arg2Of secretion,measured
R19805 T25853 T25851 arg2Of medium,in
R19806 T25853 T25852 arg1Of medium,the
R19807 T25855 T25847 arg2Of measured,and
R19808 T25855 T25848 arg1Of measured,then
R19809 T25855 T25854 arg2Of measured,was
R19810 T25856 T25857 arg1Of Data,is
R19811 T25856 T25859 arg1Of Data,of
R19812 T25859 T25857 arg2Of of,is
R19813 T25859 T25858 arg1Of of,from
R19814 T25862 T25859 arg2Of experiments,of
R19815 T25862 T25860 arg1Of experiments,three
R19816 T25862 T25861 arg1Of experiments,independent
R19817 T25864 T25863 arg1Of p-value,The
R19818 T25864 T25865 arg1Of p-value,of
R19819 T25864 T25876 arg1Of p-value,was
R19820 T25864 T25877 arg1Of p-value,0.05.
R19821 T25866 T25865 arg2Of cells,of
R19822 T25866 T25867 arg2Of cells,transfected
R19823 T25866 T25873 arg2Of cells,transfected
R19824 T25867 T25868 arg1Of transfected,with
R19825 T25867 T25870 arg1Of transfected,compared
R19826 T25869 T25868 arg2Of KD,with
R19827 T25871 T25870 arg2Of to,compared
R19828 T25872 T25871 arg2Of those,to
R19829 T25873 T25874 arg1Of transfected,with
R19830 T25875 T25874 arg2Of WT,with
R19831 T25877 T25876 arg2Of 0.05.,was
R19832 T25879 T25878 arg2Of C,(
R19833 T25880 T25878 arg3Of ),(
R19834 T25881 T25878 arg1Of MDMs,(
R19835 T25881 T25882 arg1Of MDMs,were
R19836 T25881 T25883 arg2Of MDMs,removed
R19837 T25883 T25882 arg2Of removed,were
R19838 T25883 T25884 arg1Of removed,from
R19839 T25883 T25887 modOf removed,using
R19840 T25883 T25889 arg1Of removed,and
R19841 T25886 T25884 arg2Of plate,from
R19842 T25886 T25885 arg1Of plate,the
R19843 T25888 T25887 arg2Of accutase,using
R19844 T25889 T25876 arg3Of and,was
R19845 T25890 T25891 arg1Of apoptosis,of
R19846 T25890 T25893 arg1Of apoptosis,was
R19847 T25890 T25894 arg2Of apoptosis,measured
R19848 T25890 T25898 arg1Of apoptosis,using
R19849 T25892 T25891 arg2Of MDMs,of
R19850 T25894 T25893 arg2Of measured,was
R19851 T25894 T25898 modOf measured,using
R19852 T25897 T25894 arg1Of cytometry,measured
R19853 T25897 T25895 arg2Of cytometry,by
R19854 T25897 T25896 arg1Of cytometry,flow
R19855 T25900 T25899 arg1Of V-FITC,Annexin
R19856 T25900 T25901 arg1Of V-FITC,and
R19857 T25901 T25898 arg2Of and,using
R19858 T25903 T25901 arg2Of iodine,and
R19859 T25903 T25902 arg1Of iodine,propidium
R19860 T25903 T25904 arg1Of iodine,(
R19861 T25905 T25904 arg2Of PI,(
R19862 T25906 T25904 arg3Of ),(
R19863 T25908 T25907 arg2Of (,.
R19864 T25909 T25907 arg3Of D,.
R19865 T25912 T25907 arg1Of ell lys,.
R19866 T25912 T25910 arg1Of ell lys,) Who
R19867 T25912 T25911 arg1Of ell lys,le c
R19868 T25912 T25913 arg1Of ell lys,ates
R19869 T25912 T25919 arg1Of ell lys,4.7
R19870 T25912 T25920 arg2Of ell lys,cells wer
R19871 T25918 T25913 arg2Of AW 26,ates
R19872 T25918 T25914 arg1Of AW 26,fro
R19873 T25918 T25915 arg2Of AW 26,m the trans
R19874 T25918 T25916 arg1Of AW 26,fec
R19875 T25918 T25917 arg1Of AW 26,ted R
R19876 T25920 T25889 arg2Of cells wer,and
R19877 T25920 T25893 modOf cells wer,was
R19878 T25920 T25919 arg2Of cells wer,4.7
R19879 T25920 T25921 arg1Of cells wer,e
R19880 T25924 T25921 arg2Of o Wester,e
R19881 T25924 T25922 arg1Of o Wester,subject
R19882 T25924 T25923 arg1Of o Wester,ed t
R19883 T25924 T25925 arg1Of o Wester,n bl
R19884 T25926 T25927 arg1Of ot analysis wi,th
R19885 T25928 T25927 arg2Of phospho-Ser276,th
R19886 T25931 T25925 arg2Of ho-Ser536 ,n bl
R19887 T25931 T25926 arg1Of ho-Ser536 ,ot analysis wi
R19888 T25931 T25928 arg1Of ho-Ser536 ,phospho-Ser276
R19889 T25931 T25929 arg1Of ho-Ser536 ,or ph
R19890 T25931 T25930 arg1Of ho-Ser536 ,osp
R19891 T25932 T25933 arg1Of Blots,were
R19892 T25932 T25934 arg2Of Blots,immunoblotted
R19893 T25932 T25938 arg1Of Blots,determine
R19894 T25934 T25933 arg2Of immunoblotted,were
R19895 T25934 T25935 arg1Of immunoblotted,with
R19896 T25934 T25937 modOf immunoblotted,to
R19897 T25936 T25935 arg2Of PKCα,with
R19898 T25938 T25937 arg1Of determine,to
R19899 T25941 T25938 arg2Of expression,determine
R19900 T25941 T25939 arg1Of expression,equal
R19901 T25941 T25940 arg1Of expression,protein
R19902 T25941 T25942 arg1Of expression,for
R19903 T25946 T25942 arg2Of β-actin,for
R19904 T25946 T25943 arg1Of β-actin,the
R19905 T25946 T25944 arg1Of β-actin,PKCα
R19906 T25946 T25945 arg1Of β-actin,constructs.
R19907 T25946 T25947 arg2Of β-actin,served
R19908 T25947 T25948 arg1Of served,as
R19909 T25951 T25948 arg2Of control,as
R19910 T25951 T25949 arg1Of control,a
R19911 T25951 T25950 arg1Of control,loading
R19912 T25952 T25953 arg1Of Shown,is
R19913 T25956 T25957 arg1Of blot,from
R19914 T25956 T25961 arg1Of blot,(
R19915 T25960 T25957 arg2Of experiments.,from
R19916 T25960 T25958 arg1Of experiments.,three
R19917 T25960 T25959 arg1Of experiments.,independent
R19918 T25962 T25961 arg2Of E,(
R19919 T25963 T25961 arg3Of ),(
R19920 T25964 T25954 arg1Of MDM,a
R19921 T25964 T25955 arg1Of MDM,representative
R19922 T25964 T25956 arg1Of MDM,blot
R19923 T25964 T25965 arg1Of MDM,or
R19924 T25965 T25953 arg2Of or,is
R19925 T25967 T25966 arg2Of F,(
R19926 T25968 T25966 arg3Of ),(
R19927 T25971 T25966 arg1Of cells,(
R19928 T25971 T25969 arg1Of cells,RAW
R19929 T25971 T25970 arg1Of cells,264.7
R19930 T25971 T25972 arg1Of cells,were
R19931 T25971 T25974 arg2Of cells,transfected
R19932 T25974 T25965 arg2Of transfected,or
R19933 T25974 T25972 arg2Of transfected,were
R19934 T25974 T25973 arg1Of transfected,transiently
R19935 T25974 T25975 arg1Of transfected,with
R19936 T25977 T25975 arg2Of pNF-κB-SEAP,with
R19937 T25977 T25976 arg1Of pNF-κB-SEAP,a
R19938 T25977 T25979 arg1Of pNF-κB-SEAP,with
R19939 T25979 T25978 arg1Of with,along
R19940 T25981 T25982 arg1Of 100,nM
R19941 T25984 T25981 arg1Of siRNA,100
R19942 T25984 T25983 arg1Of siRNA,PKCα
R19943 T25984 T25985 arg1Of siRNA,or
R19944 T25985 T25979 arg2Of or,with
R19945 T25985 T25980 arg1Of or,either
R19946 T25985 T25988 arg1Of or,for
R19947 T25987 T25985 arg2Of siRNA,or
R19948 T25987 T25986 arg1Of siRNA,control
R19949 T25990 T25988 arg2Of hours,for
R19950 T25990 T25989 arg1Of hours,20-24
R19951 T25991 T25992 arg1Of Cells,were
R19952 T25992 T26015 arg1Of were,and
R19953 T25993 T25992 arg2Of serum,were
R19954 T25993 T25994 arg2Of serum,starved
R19955 T25993 T25999 arg2Of serum,stimulated
R19956 T25994 T25995 arg1Of starved,for
R19957 T25994 T25998 arg1Of starved,and
R19958 T25997 T25995 arg2Of hours,for
R19959 T25997 T25996 arg1Of hours,2-4
R19960 T25999 T25998 arg2Of stimulated,and
R19961 T25999 T26000 arg1Of stimulated,with
R19962 T26001 T26002 arg1Of 100,ng/ml
R19963 T26003 T26000 arg2Of M-CSF,with
R19964 T26003 T26001 arg1Of M-CSF,100
R19965 T26003 T26004 arg1Of M-CSF,for
R19966 T26006 T26004 arg2Of hours,for
R19967 T26006 T26005 arg1Of hours,6
R19968 T26006 T26007 arg1Of hours,for
R19969 T26008 T26009 arg1Of MDM,or
R19970 T26009 T26007 arg2Of or,for
R19971 T26009 T26012 arg1Of or,for
R19972 T26010 T26009 arg2Of RAW,or
R19973 T26010 T26011 arg1Of RAW,264.7
R19974 T26014 T26012 arg2Of hours,for
R19975 T26014 T26013 arg1Of hours,2
R19976 T26018 T26017 arg1Of secretion,SEAP
R19977 T26018 T26019 arg1Of secretion,in
R19978 T26018 T26022 arg1Of secretion,was
R19979 T26018 T26023 arg2Of secretion,measured
R19980 T26021 T26019 arg2Of medium,in
R19981 T26021 T26020 arg1Of medium,the
R19982 T26023 T26015 arg2Of measured,and
R19983 T26023 T26016 arg1Of measured,then
R19984 T26023 T26022 arg2Of measured,was
R19985 T26024 T26025 arg1Of Shown,is
R19986 T26024 T26077 arg1Of Shown,were
R19987 T26024 T26078 arg2Of Shown,subjected
R19988 T26026 T26027 arg1Of data,of
R19989 T26026 T26046 arg1Of data,was
R19990 T26026 T26047 arg2Of data,measured
R19991 T26026 T26059 arg2Of data,analyzed
R19992 T26030 T26027 arg2Of experiments.,of
R19993 T26030 T26028 arg1Of experiments.,three
R19994 T26030 T26029 arg1Of experiments.,independent
R19995 T26030 T26031 arg1Of experiments.,(
R19996 T26032 T26031 arg2Of G,(
R19997 T26033 T26031 arg3Of ),(
R19998 T26034 T26035 arg1Of MDMs,were
R19999 T26034 T26036 arg2Of MDMs,removed
R20000 T26036 T26035 arg2Of removed,were
R20001 T26036 T26037 arg1Of removed,from
R20002 T26036 T26040 modOf removed,using
R20003 T26039 T26037 arg2Of plate,from
R20004 T26039 T26038 arg1Of plate,the
R20005 T26041 T26042 arg1Of accutase,and
R20006 T26042 T26040 arg2Of and,using
R20007 T26042 T26044 arg1Of and,of
R20008 T26043 T26042 arg2Of apoptosis,and
R20009 T26045 T26044 arg2Of MDMs,of
R20010 T26047 T26048 arg1Of measured,by
R20011 T26047 T26058 arg1Of measured,and
R20012 T26050 T26049 arg1Of V-FITC,Annexin
R20013 T26050 T26051 arg1Of V-FITC,and
R20014 T26053 T26051 arg2Of iodine,and
R20015 T26053 T26052 arg1Of iodine,propidium
R20016 T26053 T26054 arg1Of iodine,(
R20017 T26055 T26054 arg2Of PI,(
R20018 T26056 T26054 arg3Of ),(
R20019 T26057 T26048 arg2Of staining,by
R20020 T26057 T26050 arg1Of staining,V-FITC
R20021 T26057 T26053 arg1Of staining,iodine
R20022 T26058 T26035 modOf and,were
R20023 T26058 T26046 arg2Of and,was
R20024 T26059 T26058 arg2Of analyzed,and
R20025 T26064 T26063 arg2Of H,(
R20026 T26065 T26063 arg3Of ),(
R20027 T26068 T26061 arg1Of lysates,flow
R20028 T26068 T26062 arg1Of lysates,cytometry.
R20029 T26068 T26063 arg1Of lysates,(
R20030 T26068 T26066 arg1Of lysates,Whole
R20031 T26068 T26067 arg1Of lysates,cell
R20032 T26068 T26069 arg1Of lysates,from
R20033 T26068 T26073 arg1Of lysates,and
R20034 T26072 T26069 arg2Of MDM,from
R20035 T26072 T26070 arg1Of MDM,the
R20036 T26072 T26071 arg2Of MDM,transfected
R20037 T26073 T26059 arg1Of and,analyzed
R20038 T26073 T26060 arg2Of and,by
R20039 T26076 T26073 arg2Of cells,and
R20040 T26076 T26074 arg1Of cells,RAW
R20041 T26076 T26075 arg1Of cells,264.7
R20042 T26078 T26025 arg2Of subjected,is
R20043 T26078 T26046 modOf subjected,was
R20044 T26078 T26077 arg2Of subjected,were
R20045 T26078 T26079 arg1Of subjected,to
R20046 T26082 T26079 arg2Of analysis,to
R20047 T26082 T26080 arg1Of analysis,Western
R20048 T26082 T26081 arg1Of analysis,blot
R20049 T26082 T26083 arg1Of analysis,with
R20050 T26086 T26083 arg2Of β-actin,with
R20051 T26086 T26084 arg1Of β-actin,PKCα
R20052 T26086 T26085 arg1Of β-actin,antibody.
R20053 T26086 T26087 arg2Of β-actin,served
R20054 T26087 T26088 arg1Of served,as
R20055 T26091 T26088 arg2Of control,as
R20056 T26091 T26089 arg1Of control,a
R20057 T26091 T26090 arg1Of control,loading
R20058 T26092 T26093 arg1Of Shown,is
R20059 T26096 T26093 arg2Of blot,is
R20060 T26096 T26094 arg1Of blot,a
R20061 T26096 T26095 arg1Of blot,representative
R20062 T26096 T26097 arg1Of blot,from
R20063 T26100 T26098 arg1Of three,at
R20064 T26100 T26099 arg1Of three,least
R20065 T26102 T26097 arg2Of experiments,from
R20066 T26102 T26100 arg1Of experiments,three
R20067 T26102 T26101 arg1Of experiments,independent

sentences

Id Subject Object Predicate Lexical cue
T10217 0-74 Sentence denotes Identification of PKCα as the Upstream Activator of NF-κB in Myeloid Cells
T10218 75-302 Sentence denotes Even though the PKC family consists of 10 members, finding that PKCα/β inhibitors and intracellular calcium inhibitors reduced M-CSF-induced NF-κB activity, suggested PKCα was involved in NF-κB activation after M-CSF treatment.
T10219 303-524 Sentence denotes To confirm the role of PKCα in NF-κB activation in macrophages, constructs for either wildtype (WT)-PKCα or kinase-deficient (KD)-PKCα was co-transfected with the pNF-κB-SEAP reporter gene and SEAP secretion was measured.
T10220 525-772 Sentence denotes As shown in Figure 7A, MDMs co-transfected with pNF-κB-SEAP and WT-PKCα had a 1.8-fold increase in NF-κB transcriptional activity after M-CSF activation compared with NS cells (p = 0.05), similar to M-CSF-treated cells expressing only pNF-κB-SEAP.
T10221 773-932 Sentence denotes Transfecting human macrophages with the KD-PKCα construct significantly reduced M-CSF-induced NF-κB activity compared to WT-PKCα transfected cells (p = 0.016).
T10222 933-1140 Sentence denotes Similarly, RAW 264.7 cells transfected with WT-PKCα had 2.5-fold more NF-κB transcriptional activity after M-CSF activation compared to unstimulated RAW 264.7 cells (NS) transfected with WT-PKCα (Figure 7B).
T10223 1141-1302 Sentence denotes Expression of the KD-PKCα construct into RAW 264.7 cells reduced M-CSF-induced NF-κB activity to 1.5-fold (p = 0.045) compared to cells transfected with WT PKCα.
T10224 3103-3225 Sentence denotes Cell survival was also examined in MDMs expressing either WT-PKCα or KD-PKCα constructs by Annexin V-FITC and PI staining.
T10225 3226-3326 Sentence denotes As expected, M-CSF increased MDM survival as measured by the percent of Annexin V/PI negative cells.
T10226 3327-3391 Sentence denotes Similarly, expression of WT-PKCα protected cells from apoptosis.
T10227 3392-3486 Sentence denotes In contrast, expression of KD-PKCα decreased M-CSF-induced cell survival (p<0.01) (Figure 7C).
T10228 3487-3575 Sentence denotes Next, we examined the effect of expressing the PKCα constructs on NF-κB phosphorylation.
T10229 3576-3757 Sentence denotes As shown in Figure 7D, expression of KD-PKCα in RAW 264.7 cells did not affect the constitutive phosphorylation at Ser536 of NF-κB p65, but attenuated the phosphorylation at Ser276.
T10230 3758-3867 Sentence denotes Expression of WT-PKCα did not effect the phosphorylation of either residue with or without M-CSF stimulation.
T10231 3868-4044 Sentence denotes These observations demonstrate that PKCα is important in M-CSF-regulated cell survival and NF-κB activation and likely regulated through phosphorylation of Ser276 of NF-κB p65.
T10232 4045-4200 Sentence denotes To further validate the impact that PKCα played in M-CSF-induced NF-κB transcriptional activity, we next employed PKCα siRNA treatment of MDM or RAW cells.
T10233 4201-4312 Sentence denotes A pool of specific PKCα siRNA were transfected into MDM or Raw 264.7 cells in the presence or absence or M-CSF.
T10234 4313-4479 Sentence denotes Reducing native PKCα expression decreased M-CSF-induced NF-κB transcriptional activity in both MDM (Figure 7E) (p = 0.012) and Raw 264.7 cells (Figure 7F) (p = 0.01).
T10235 4480-4587 Sentence denotes We also examined cell survival of the MDMs by Annexin V-FITC and PI staining after PKCα siRNA transfection.
T10236 4588-4754 Sentence denotes As shown in Figure 7G, M-CSF-induced MDM survival was reduced in the cells transfected with PKCα siRNA compared with cells transfected with control siRNA (p = 0.047).
T10237 4755-4877 Sentence denotes In Figure 7H, we confirmed that PKCα siRNA transfection decreased PKCα protein expression in both MDM and Raw 264.7 cells.
T10238 4878-4971 Sentence denotes Our results indicated that PKCα regulated NF-κB activation and M-CSF-regulated cell survival.
T25465 1347-1401 Sentence denotes PKCα regulates phosphorylation of NF-κB p65 at Ser276.
T25466 1402-1564 Sentence denotes (A) MDM or (B) RAW 264.7 cells were transiently transfected with pNF-κB-SEAP along with either WT-PKCα or the kinase-deficient (KD)-PKCα construct at a 1∶5 ratio.
T25467 1565-1667 Sentence denotes Cells were serum starved and stimulated with M-CSF and then SEAP secretion in the medium was measured.
T25468 1668-1714 Sentence denotes Data is from of three independent experiments.
T25469 1715-2116 Sentence denotes The p-value of cells transfected with KD compared to those transfected with WT was 0.05. (C) MDMs were removed from the plate using accutase and apoptosis of MDMs was measured by flow cytometry using Annexin V-FITC and propidium iodine (PI). (D) Whole cell lysates from the transfected RAW 264.7 cells were subjected to Western blot analysis with phospho-Ser276 or phospho-Ser536 NF-κB p65 antibodies.
T25470 2117-2251 Sentence denotes Blots were immunoblotted with PKCα to determine equal protein expression for the PKCα constructs. β-actin served as a loading control.
T25471 2252-2467 Sentence denotes Shown is a representative blot from three independent experiments. (E) MDM or (F) RAW 264.7 cells were transiently transfected with a pNF-κB-SEAP along with either 100 nM PKCα siRNA or control siRNA for 20-24 hours.
T25472 2468-2639 Sentence denotes Cells were serum starved for 2-4 hours and stimulated with 100 ng/ml M-CSF for 6 hours for MDM or RAW 264.7 for 2 hours and then SEAP secretion in the medium was measured.
T25473 2640-3024 Sentence denotes Shown is data of three independent experiments. (G) MDMs were removed from the plate using accutase and apoptosis of MDMs was measured by Annexin V-FITC and propidium iodine (PI) staining and analyzed by flow cytometry. (H) Whole cell lysates from the transfected MDM and RAW 264.7 cells were subjected to Western blot analysis with PKCα antibody. β-actin served as a loading control.
T25474 3025-3100 Sentence denotes Shown is a representative blot from at least three independent experiments.
T167 0-74 Sentence denotes Identification of PKCα as the Upstream Activator of NF-κB in Myeloid Cells
T168 75-302 Sentence denotes Even though the PKC family consists of 10 members, finding that PKCα/β inhibitors and intracellular calcium inhibitors reduced M-CSF-induced NF-κB activity, suggested PKCα was involved in NF-κB activation after M-CSF treatment.
T169 303-524 Sentence denotes To confirm the role of PKCα in NF-κB activation in macrophages, constructs for either wildtype (WT)-PKCα or kinase-deficient (KD)-PKCα was co-transfected with the pNF-κB-SEAP reporter gene and SEAP secretion was measured.
T170 525-772 Sentence denotes As shown in Figure 7A, MDMs co-transfected with pNF-κB-SEAP and WT-PKCα had a 1.8-fold increase in NF-κB transcriptional activity after M-CSF activation compared with NS cells (p = 0.05), similar to M-CSF-treated cells expressing only pNF-κB-SEAP.
T171 773-932 Sentence denotes Transfecting human macrophages with the KD-PKCα construct significantly reduced M-CSF-induced NF-κB activity compared to WT-PKCα transfected cells (p = 0.016).
T172 933-1140 Sentence denotes Similarly, RAW 264.7 cells transfected with WT-PKCα had 2.5-fold more NF-κB transcriptional activity after M-CSF activation compared to unstimulated RAW 264.7 cells (NS) transfected with WT-PKCα (Figure 7B).
T173 1141-1302 Sentence denotes Expression of the KD-PKCα construct into RAW 264.7 cells reduced M-CSF-induced NF-κB activity to 1.5-fold (p = 0.045) compared to cells transfected with WT PKCα.
T174 1303-1401 Sentence denotes 10.1371/journal.pone.0028081.g007 Figure 7 PKCα regulates phosphorylation of NF-κB p65 at Ser276.
T175 1402-1564 Sentence denotes (A) MDM or (B) RAW 264.7 cells were transiently transfected with pNF-κB-SEAP along with either WT-PKCα or the kinase-deficient (KD)-PKCα construct at a 1∶5 ratio.
T176 1565-1667 Sentence denotes Cells were serum starved and stimulated with M-CSF and then SEAP secretion in the medium was measured.
T177 1668-1714 Sentence denotes Data is from of three independent experiments.
T178 1715-2116 Sentence denotes The p-value of cells transfected with KD compared to those transfected with WT was 0.05. (C) MDMs were removed from the plate using accutase and apoptosis of MDMs was measured by flow cytometry using Annexin V-FITC and propidium iodine (PI). (D) Whole cell lysates from the transfected RAW 264.7 cells were subjected to Western blot analysis with phospho-Ser276 or phospho-Ser536 NF-κB p65 antibodies.
T179 2117-2251 Sentence denotes Blots were immunoblotted with PKCα to determine equal protein expression for the PKCα constructs. β-actin served as a loading control.
T180 2252-2467 Sentence denotes Shown is a representative blot from three independent experiments. (E) MDM or (F) RAW 264.7 cells were transiently transfected with a pNF-κB-SEAP along with either 100 nM PKCα siRNA or control siRNA for 20-24 hours.
T181 2468-2639 Sentence denotes Cells were serum starved for 2-4 hours and stimulated with 100 ng/ml M-CSF for 6 hours for MDM or RAW 264.7 for 2 hours and then SEAP secretion in the medium was measured.
T182 2640-3024 Sentence denotes Shown is data of three independent experiments. (G) MDMs were removed from the plate using accutase and apoptosis of MDMs was measured by Annexin V-FITC and propidium iodine (PI) staining and analyzed by flow cytometry. (H) Whole cell lysates from the transfected MDM and RAW 264.7 cells were subjected to Western blot analysis with PKCα antibody. β-actin served as a loading control.
T183 3025-3100 Sentence denotes Shown is a representative blot from at least three independent experiments.
T184 3103-3225 Sentence denotes Cell survival was also examined in MDMs expressing either WT-PKCα or KD-PKCα constructs by Annexin V-FITC and PI staining.
T185 3226-3326 Sentence denotes As expected, M-CSF increased MDM survival as measured by the percent of Annexin V/PI negative cells.
T186 3327-3391 Sentence denotes Similarly, expression of WT-PKCα protected cells from apoptosis.
T187 3392-3486 Sentence denotes In contrast, expression of KD-PKCα decreased M-CSF-induced cell survival (p<0.01) (Figure 7C).
T188 3487-3575 Sentence denotes Next, we examined the effect of expressing the PKCα constructs on NF-κB phosphorylation.
T189 3576-3757 Sentence denotes As shown in Figure 7D, expression of KD-PKCα in RAW 264.7 cells did not affect the constitutive phosphorylation at Ser536 of NF-κB p65, but attenuated the phosphorylation at Ser276.
T190 3758-3867 Sentence denotes Expression of WT-PKCα did not effect the phosphorylation of either residue with or without M-CSF stimulation.
T191 3868-4044 Sentence denotes These observations demonstrate that PKCα is important in M-CSF-regulated cell survival and NF-κB activation and likely regulated through phosphorylation of Ser276 of NF-κB p65.
T192 4045-4200 Sentence denotes To further validate the impact that PKCα played in M-CSF-induced NF-κB transcriptional activity, we next employed PKCα siRNA treatment of MDM or RAW cells.
T193 4201-4312 Sentence denotes A pool of specific PKCα siRNA were transfected into MDM or Raw 264.7 cells in the presence or absence or M-CSF.
T194 4313-4479 Sentence denotes Reducing native PKCα expression decreased M-CSF-induced NF-κB transcriptional activity in both MDM (Figure 7E) (p = 0.012) and Raw 264.7 cells (Figure 7F) (p = 0.01).
T195 4480-4587 Sentence denotes We also examined cell survival of the MDMs by Annexin V-FITC and PI staining after PKCα siRNA transfection.
T196 4588-4754 Sentence denotes As shown in Figure 7G, M-CSF-induced MDM survival was reduced in the cells transfected with PKCα siRNA compared with cells transfected with control siRNA (p = 0.047).
T197 4755-4877 Sentence denotes In Figure 7H, we confirmed that PKCα siRNA transfection decreased PKCα protein expression in both MDM and Raw 264.7 cells.
T198 4878-4971 Sentence denotes Our results indicated that PKCα regulated NF-κB activation and M-CSF-regulated cell survival.

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T10239 0-14 NN denotes Identification
T10240 15-17 IN denotes of
T10241 18-22 NNP denotes PKCα
T10242 23-25 IN denotes as
T10243 26-29 DT denotes the
T10244 30-38 NNP denotes Upstream
T10245 39-48 NNP denotes Activator
T10246 49-51 IN denotes of
T10247 52-57 NNP denotes NF-κB
T10248 58-60 IN denotes in
T10249 61-68 NNP denotes Myeloid
T10250 69-74 NNP denotes Cells
T10251 75-79 RB denotes Even
T10252 80-86 IN denotes though
T10253 87-90 DT denotes the
T10254 91-94 NNP denotes PKC
T10255 95-101 NN denotes family
T10256 102-110 VBZ denotes consists
T10257 111-113 IN denotes of
T10258 114-116 CD denotes 10
T10259 117-124 NNS denotes members
T10260 124-125 , denotes ,
T10261 126-133 VBG denotes finding
T10262 134-138 IN denotes that
T10263 139-143 NNP denotes PKCα
T10264 143-144 NNP denotes /
T10265 144-145 VBD denotes β
T10266 146-156 NNS denotes inhibitors
T10267 157-160 CC denotes and
T10268 161-174 JJ denotes intracellular
T10269 175-182 NN denotes calcium
T10270 183-193 NNS denotes inhibitors
T10271 194-201 VBD denotes reduced
T10272 202-215 JJ denotes M-CSF-induced
T10273 216-221 NN denotes NF-κB
T10274 222-230 NN denotes activity
T10275 230-231 , denotes ,
T10276 232-241 VBD denotes suggested
T10277 242-246 NNP denotes PKCα
T10278 247-250 VBD denotes was
T10279 251-259 VBN denotes involved
T10280 260-262 IN denotes in
T10281 263-268 JJ denotes NF-κB
T10282 269-279 NN denotes activation
T10283 280-285 IN denotes after
T10284 286-291 NNP denotes M-CSF
T10285 292-301 NN denotes treatment
T10286 301-302 . denotes .
T10287 303-305 TO denotes To
T10288 306-313 VB denotes confirm
T10289 314-317 DT denotes the
T10290 318-322 NN denotes role
T10291 323-325 IN denotes of
T10292 326-330 NNP denotes PKCα
T10293 331-333 IN denotes in
T10294 334-339 NNP denotes NF-κB
T10295 340-350 NN denotes activation
T10296 351-353 IN denotes in
T10297 354-365 NNS denotes macrophages
T10298 365-366 , denotes ,
T10299 367-377 NNS denotes constructs
T10300 378-381 IN denotes for
T10301 382-388 DT denotes either
T10302 389-397 NN denotes wildtype
T10303 398-399 -LRB- denotes (
T10304 399-401 NNP denotes WT
T10305 401-402 -RRB- denotes )
T10306 402-403 : denotes -
T10307 403-407 NN denotes PKCα
T10308 408-410 CC denotes or
T10309 411-427 NN denotes kinase-deficient
T10310 428-429 -LRB- denotes (
T10311 429-431 NNP denotes KD
T10312 431-432 -RRB- denotes )
T10313 432-433 : denotes -
T10314 433-437 NN denotes PKCα
T10315 438-441 VBD denotes was
T10316 442-456 VBN denotes co-transfected
T10317 457-461 IN denotes with
T10318 462-465 DT denotes the
T10319 466-477 JJ denotes pNF-κB-SEAP
T10320 478-486 NN denotes reporter
T10321 487-491 NN denotes gene
T10322 492-495 CC denotes and
T10323 496-500 NNP denotes SEAP
T10324 501-510 NN denotes secretion
T10325 511-514 VBD denotes was
T10326 515-523 VBN denotes measured
T10327 523-524 . denotes .
T10328 525-527 IN denotes As
T10329 528-533 VBN denotes shown
T10330 534-536 IN denotes in
T10331 537-543 NN denotes Figure
T10332 544-546 NN denotes 7A
T10333 546-547 , denotes ,
T10334 548-552 NNP denotes MDMs
T10335 553-567 VBD denotes co-transfected
T10336 568-572 IN denotes with
T10337 573-584 NNP denotes pNF-κB-SEAP
T10338 585-588 CC denotes and
T10339 589-596 NNP denotes WT-PKCα
T10340 597-600 VBD denotes had
T10341 601-602 DT denotes a
T10342 603-611 JJ denotes 1.8-fold
T10343 612-620 NN denotes increase
T10344 621-623 IN denotes in
T10345 624-629 JJ denotes NF-κB
T10346 630-645 JJ denotes transcriptional
T10347 646-654 NN denotes activity
T10348 655-660 IN denotes after
T10349 661-666 NNP denotes M-CSF
T10350 667-677 NN denotes activation
T10351 678-686 VBN denotes compared
T10352 687-691 IN denotes with
T10353 692-694 NNP denotes NS
T10354 695-700 NNS denotes cells
T10355 701-702 -LRB- denotes (
T10356 702-703 FW denotes p
T10357 704-705 SYM denotes =
T10358 706-710 CD denotes 0.05
T10359 710-711 -RRB- denotes )
T10360 711-712 , denotes ,
T10361 713-720 JJ denotes similar
T10362 721-723 TO denotes to
T10363 724-737 JJ denotes M-CSF-treated
T10364 738-743 NNS denotes cells
T10365 744-754 VBG denotes expressing
T10366 755-759 RB denotes only
T10367 760-771 JJ denotes pNF-κB-SEAP
T10368 771-772 . denotes .
T10369 773-785 VBG denotes Transfecting
T10370 786-791 JJ denotes human
T10371 792-803 NNS denotes macrophages
T10372 804-808 IN denotes with
T10373 809-812 DT denotes the
T10374 813-820 NNP denotes KD-PKCα
T10375 821-830 VBP denotes construct
T10376 831-844 RB denotes significantly
T10377 845-852 VBN denotes reduced
T10378 853-866 JJ denotes M-CSF-induced
T10379 867-872 NN denotes NF-κB
T10380 873-881 NN denotes activity
T10381 882-890 VBN denotes compared
T10382 891-893 TO denotes to
T10383 894-901 JJ denotes WT-PKCα
T10384 902-913 VBN denotes transfected
T10385 914-919 NNS denotes cells
T10386 920-921 -LRB- denotes (
T10387 921-922 FW denotes p
T10388 923-924 SYM denotes =
T10389 925-930 CD denotes 0.016
T10390 930-931 -RRB- denotes )
T10391 931-932 . denotes .
T10392 933-942 RB denotes Similarly
T10393 942-943 , denotes ,
T10394 944-947 NNP denotes RAW
T10395 948-953 CD denotes 264.7
T10396 954-959 NNS denotes cells
T10397 960-971 VBN denotes transfected
T10398 972-976 IN denotes with
T10399 977-984 NNP denotes WT-PKCα
T10400 985-988 VBD denotes had
T10401 989-997 CD denotes 2.5-fold
T10402 998-1002 JJR denotes more
T10403 1003-1008 JJ denotes NF-κB
T10404 1009-1024 NN denotes transcriptional
T10405 1025-1033 NN denotes activity
T10406 1034-1039 IN denotes after
T10407 1040-1045 NNP denotes M-CSF
T10408 1046-1056 NN denotes activation
T10409 1057-1065 VBN denotes compared
T10410 1066-1068 TO denotes to
T10411 1069-1081 JJ denotes unstimulated
T10412 1082-1085 NNP denotes RAW
T10413 1086-1091 CD denotes 264.7
T10414 1092-1097 NNS denotes cells
T10415 1098-1099 -LRB- denotes (
T10416 1099-1101 NNP denotes NS
T10417 1101-1102 -RRB- denotes )
T10418 1103-1114 VBN denotes transfected
T10419 1115-1119 IN denotes with
T10420 1120-1127 NNP denotes WT-PKCα
T10421 1128-1129 -LRB- denotes (
T10422 1129-1135 NNP denotes Figure
T10423 1136-1138 NN denotes 7B
T10424 1138-1139 -RRB- denotes )
T10425 1139-1140 . denotes .
T10426 1141-1151 NN denotes Expression
T10427 1152-1154 IN denotes of
T10428 1155-1158 DT denotes the
T10429 1159-1166 NNP denotes KD-PKCα
T10430 1167-1176 VBP denotes construct
T10431 1177-1181 IN denotes into
T10432 1182-1185 NNP denotes RAW
T10433 1186-1191 CD denotes 264.7
T10434 1192-1197 NNS denotes cells
T10435 1198-1205 VBN denotes reduced
T10436 1206-1219 JJ denotes M-CSF-induced
T10437 1220-1225 NN denotes NF-κB
T10438 1226-1234 NN denotes activity
T10439 1235-1237 TO denotes to
T10440 1238-1246 CD denotes 1.5-fold
T10441 1247-1248 -LRB- denotes (
T10442 1248-1249 NN denotes p
T10443 1250-1251 SYM denotes =
T10444 1252-1257 CD denotes 0.045
T10445 1257-1258 -RRB- denotes )
T10446 1259-1267 VBN denotes compared
T10447 1268-1270 TO denotes to
T10448 1271-1276 NNS denotes cells
T10449 1277-1288 VBN denotes transfected
T10450 1289-1293 IN denotes with
T10451 1294-1296 NNP denotes WT
T10452 1297-1301 NNP denotes PKCα
T10453 1301-1302 . denotes .
T10454 3103-3107 NNP denotes Cell
T10455 3108-3116 NN denotes survival
T10456 3117-3120 VBD denotes was
T10457 3121-3125 RB denotes also
T10458 3126-3134 VBN denotes examined
T10459 3135-3137 IN denotes in
T10460 3138-3142 NNS denotes MDMs
T10461 3143-3153 VBG denotes expressing
T10462 3154-3160 CC denotes either
T10463 3161-3168 NNP denotes WT-PKCα
T10464 3169-3171 CC denotes or
T10465 3172-3179 NNP denotes KD-PKCα
T10466 3180-3190 NNS denotes constructs
T10467 3191-3193 IN denotes by
T10468 3194-3201 NNP denotes Annexin
T10469 3202-3208 NNP denotes V-FITC
T10470 3209-3212 CC denotes and
T10471 3213-3215 NNP denotes PI
T10472 3216-3224 VBG denotes staining
T10473 3224-3225 . denotes .
T10474 3226-3228 IN denotes As
T10475 3229-3237 VBN denotes expected
T10476 3237-3238 , denotes ,
T10477 3239-3244 NNP denotes M-CSF
T10478 3245-3254 VBD denotes increased
T10479 3255-3258 NNP denotes MDM
T10480 3259-3267 NN denotes survival
T10481 3268-3270 IN denotes as
T10482 3271-3279 VBN denotes measured
T10483 3280-3282 IN denotes by
T10484 3283-3286 DT denotes the
T10485 3287-3294 NN denotes percent
T10486 3295-3297 IN denotes of
T10487 3298-3305 NNP denotes Annexin
T10488 3306-3310 NNP denotes V/PI
T10489 3311-3319 JJ denotes negative
T10490 3320-3325 NNS denotes cells
T10491 3325-3326 . denotes .
T10492 3327-3336 RB denotes Similarly
T10493 3336-3337 , denotes ,
T10494 3338-3348 NN denotes expression
T10495 3349-3351 IN denotes of
T10496 3352-3359 JJ denotes WT-PKCα
T10497 3360-3369 JJ denotes protected
T10498 3370-3375 NNS denotes cells
T10499 3376-3380 IN denotes from
T10500 3381-3390 NN denotes apoptosis
T10501 3390-3391 . denotes .
T10502 3392-3394 IN denotes In
T10503 3395-3403 NN denotes contrast
T10504 3403-3404 , denotes ,
T10505 3405-3415 NN denotes expression
T10506 3416-3418 IN denotes of
T10507 3419-3426 NNP denotes KD-PKCα
T10508 3427-3436 VBD denotes decreased
T10509 3437-3450 JJ denotes M-CSF-induced
T10510 3451-3455 NN denotes cell
T10511 3456-3464 NN denotes survival
T10512 3465-3466 -LRB- denotes (
T10513 3466-3467 FW denotes p
T10514 3467-3468 FW denotes <
T10515 3468-3472 CD denotes 0.01
T10516 3472-3473 -RRB- denotes )
T10517 3474-3475 -LRB- denotes (
T10518 3475-3481 NN denotes Figure
T10519 3482-3484 NN denotes 7C
T10520 3484-3485 -RRB- denotes )
T10521 3485-3486 . denotes .
T10522 3487-3491 JJ denotes Next
T10523 3491-3492 , denotes ,
T10524 3493-3495 PRP denotes we
T10525 3496-3504 VBD denotes examined
T10526 3505-3508 DT denotes the
T10527 3509-3515 NN denotes effect
T10528 3516-3518 IN denotes of
T10529 3519-3529 VBG denotes expressing
T10530 3530-3533 DT denotes the
T10531 3534-3538 NNP denotes PKCα
T10532 3539-3549 NNS denotes constructs
T10533 3550-3552 IN denotes on
T10534 3553-3558 JJ denotes NF-κB
T10535 3559-3574 NN denotes phosphorylation
T10536 3574-3575 . denotes .
T10537 3576-3578 IN denotes As
T10538 3579-3584 VBN denotes shown
T10539 3585-3587 IN denotes in
T10540 3588-3594 NN denotes Figure
T10541 3595-3597 CD denotes 7D
T10542 3597-3598 , denotes ,
T10543 3599-3609 NN denotes expression
T10544 3610-3612 IN denotes of
T10545 3613-3620 NNP denotes KD-PKCα
T10546 3621-3623 IN denotes in
T10547 3624-3627 NNP denotes RAW
T10548 3628-3633 CD denotes 264.7
T10549 3634-3639 NNS denotes cells
T10550 3640-3643 VBD denotes did
T10551 3644-3647 RB denotes not
T10552 3648-3654 VB denotes affect
T10553 3655-3658 DT denotes the
T10554 3659-3671 JJ denotes constitutive
T10555 3672-3687 NN denotes phosphorylation
T10556 3688-3690 IN denotes at
T10557 3691-3697 NNP denotes Ser536
T10558 3698-3700 IN denotes of
T10559 3701-3706 NNP denotes NF-κB
T10560 3707-3710 CD denotes p65
T10561 3710-3711 , denotes ,
T10562 3712-3715 CC denotes but
T10563 3716-3726 VBD denotes attenuated
T10564 3727-3730 DT denotes the
T10565 3731-3746 NN denotes phosphorylation
T10566 3747-3749 IN denotes at
T10567 3750-3756 NNP denotes Ser276
T10568 3756-3757 . denotes .
T10569 3758-3768 NN denotes Expression
T10570 3769-3771 IN denotes of
T10571 3772-3779 NNP denotes WT-PKCα
T10572 3780-3783 VBD denotes did
T10573 3784-3787 RB denotes not
T10574 3788-3794 NN denotes effect
T10575 3795-3798 DT denotes the
T10576 3799-3814 NN denotes phosphorylation
T10577 3815-3817 IN denotes of
T10578 3818-3824 DT denotes either
T10579 3825-3832 NN denotes residue
T10580 3833-3837 IN denotes with
T10581 3838-3840 CC denotes or
T10582 3841-3848 IN denotes without
T10583 3849-3854 NNP denotes M-CSF
T10584 3855-3866 NN denotes stimulation
T10585 3866-3867 . denotes .
T10586 3868-3873 DT denotes These
T10587 3874-3886 NNS denotes observations
T10588 3887-3898 VBP denotes demonstrate
T10589 3899-3903 IN denotes that
T10590 3904-3908 NNP denotes PKCα
T10591 3909-3911 VBZ denotes is
T10592 3912-3921 JJ denotes important
T10593 3922-3924 IN denotes in
T10594 3925-3940 JJ denotes M-CSF-regulated
T10595 3941-3945 NN denotes cell
T10596 3946-3954 NN denotes survival
T10597 3955-3958 CC denotes and
T10598 3959-3964 JJ denotes NF-κB
T10599 3965-3975 NN denotes activation
T10600 3976-3979 CC denotes and
T10601 3980-3986 JJ denotes likely
T10602 3987-3996 VBN denotes regulated
T10603 3997-4004 IN denotes through
T10604 4005-4020 NN denotes phosphorylation
T10605 4021-4023 IN denotes of
T10606 4024-4030 NNP denotes Ser276
T10607 4031-4033 IN denotes of
T10608 4034-4039 NNP denotes NF-κB
T10609 4040-4043 NNS denotes p65
T10610 4043-4044 . denotes .
T10611 4045-4047 TO denotes To
T10612 4048-4055 RBR denotes further
T10613 4056-4064 VB denotes validate
T10614 4065-4068 DT denotes the
T10615 4069-4075 NN denotes impact
T10616 4076-4080 WDT denotes that
T10617 4081-4085 NNP denotes PKCα
T10618 4086-4092 VBD denotes played
T10619 4093-4095 IN denotes in
T10620 4096-4109 JJ denotes M-CSF-induced
T10621 4110-4115 NN denotes NF-κB
T10622 4116-4131 JJ denotes transcriptional
T10623 4132-4140 NN denotes activity
T10624 4140-4141 , denotes ,
T10625 4142-4144 PRP denotes we
T10626 4145-4149 JJ denotes next
T10627 4150-4158 VBN denotes employed
T10628 4159-4163 NNP denotes PKCα
T10629 4164-4169 NNP denotes siRNA
T10630 4170-4179 NN denotes treatment
T10631 4180-4182 IN denotes of
T10632 4183-4186 NNP denotes MDM
T10633 4187-4189 CC denotes or
T10634 4190-4193 NNP denotes RAW
T10635 4194-4199 NNS denotes cells
T10636 4199-4200 . denotes .
T10637 4201-4202 DT denotes A
T10638 4203-4207 NN denotes pool
T10639 4208-4210 IN denotes of
T10640 4211-4219 JJ denotes specific
T10641 4220-4224 NNP denotes PKCα
T10642 4225-4230 NNP denotes siRNA
T10643 4231-4235 VBD denotes were
T10644 4236-4247 VBN denotes transfected
T10645 4248-4252 IN denotes into
T10646 4253-4256 NNP denotes MDM
T10647 4257-4259 CC denotes or
T10648 4260-4263 NNP denotes Raw
T10649 4264-4269 CD denotes 264.7
T10650 4270-4275 NNS denotes cells
T10651 4276-4278 IN denotes in
T10652 4279-4282 DT denotes the
T10653 4283-4291 NN denotes presence
T10654 4292-4294 CC denotes or
T10655 4295-4302 NN denotes absence
T10656 4303-4305 CC denotes or
T10657 4306-4311 NN denotes M-CSF
T10658 4311-4312 . denotes .
T10659 4313-4321 VBG denotes Reducing
T10660 4322-4328 JJ denotes native
T10661 4329-4333 NNP denotes PKCα
T10662 4334-4344 NN denotes expression
T10663 4345-4354 VBD denotes decreased
T10664 4355-4368 JJ denotes M-CSF-induced
T10665 4369-4374 NN denotes NF-κB
T10666 4375-4390 JJ denotes transcriptional
T10667 4391-4399 NN denotes activity
T10668 4400-4402 IN denotes in
T10669 4403-4407 DT denotes both
T10670 4408-4411 NNP denotes MDM
T10671 4412-4413 -LRB- denotes (
T10672 4413-4419 NNP denotes Figure
T10673 4420-4422 NNP denotes 7E
T10674 4422-4423 -RRB- denotes )
T10675 4424-4425 -LRB- denotes (
T10676 4425-4426 FW denotes p
T10677 4427-4428 SYM denotes =
T10678 4429-4434 CD denotes 0.012
T10679 4434-4435 -RRB- denotes )
T10680 4436-4439 CC denotes and
T10681 4440-4443 NNP denotes Raw
T10682 4444-4449 CD denotes 264.7
T10683 4450-4455 NNS denotes cells
T10684 4456-4457 -LRB- denotes (
T10685 4457-4463 NN denotes Figure
T10686 4464-4466 CD denotes 7F
T10687 4466-4467 -RRB- denotes )
T10688 4468-4469 -LRB- denotes (
T10689 4469-4470 FW denotes p
T10690 4471-4472 SYM denotes =
T10691 4473-4477 CD denotes 0.01
T10692 4477-4478 -RRB- denotes )
T10693 4478-4479 . denotes .
T10694 4480-4482 PRP denotes We
T10695 4483-4487 RB denotes also
T10696 4488-4496 VBD denotes examined
T10697 4497-4501 NN denotes cell
T10698 4502-4510 NN denotes survival
T10699 4511-4513 IN denotes of
T10700 4514-4517 DT denotes the
T10701 4518-4522 NNS denotes MDMs
T10702 4523-4525 IN denotes by
T10703 4526-4533 NNP denotes Annexin
T10704 4534-4540 NNP denotes V-FITC
T10705 4541-4544 CC denotes and
T10706 4545-4547 NNP denotes PI
T10707 4548-4556 VBG denotes staining
T10708 4557-4562 IN denotes after
T10709 4563-4567 NNP denotes PKCα
T10710 4568-4573 NNP denotes siRNA
T10711 4574-4586 NN denotes transfection
T10712 4586-4587 . denotes .
T10713 4588-4590 IN denotes As
T10714 4591-4596 VBN denotes shown
T10715 4597-4599 IN denotes in
T10716 4600-4606 NN denotes Figure
T10717 4607-4609 CD denotes 7G
T10718 4609-4610 , denotes ,
T10719 4611-4624 JJ denotes M-CSF-induced
T10720 4625-4628 NNP denotes MDM
T10721 4629-4637 NN denotes survival
T10722 4638-4641 VBD denotes was
T10723 4642-4649 VBN denotes reduced
T10724 4650-4652 IN denotes in
T10725 4653-4656 DT denotes the
T10726 4657-4662 NNS denotes cells
T10727 4663-4674 VBN denotes transfected
T10728 4675-4679 IN denotes with
T10729 4680-4684 NNP denotes PKCα
T10730 4685-4690 NNP denotes siRNA
T10731 4691-4699 VBN denotes compared
T10732 4700-4704 IN denotes with
T10733 4705-4710 NNS denotes cells
T10734 4711-4722 VBN denotes transfected
T10735 4723-4727 IN denotes with
T10736 4728-4735 NN denotes control
T10737 4736-4741 NNP denotes siRNA
T10738 4742-4743 -LRB- denotes (
T10739 4743-4744 FW denotes p
T10740 4745-4746 SYM denotes =
T10741 4747-4752 CD denotes 0.047
T10742 4752-4753 -RRB- denotes )
T10743 4753-4754 . denotes .
T10744 4755-4757 IN denotes In
T10745 4758-4764 NN denotes Figure
T10746 4765-4767 CD denotes 7H
T10747 4767-4768 , denotes ,
T10748 4769-4771 PRP denotes we
T10749 4772-4781 VBD denotes confirmed
T10750 4782-4786 IN denotes that
T10751 4787-4791 NNP denotes PKCα
T10752 4792-4797 NNP denotes siRNA
T10753 4798-4810 NN denotes transfection
T10754 4811-4820 VBD denotes decreased
T10755 4821-4825 NNP denotes PKCα
T10756 4826-4833 NN denotes protein
T10757 4834-4844 NN denotes expression
T10758 4845-4847 IN denotes in
T10759 4848-4852 DT denotes both
T10760 4853-4856 NNP denotes MDM
T10761 4857-4860 CC denotes and
T10762 4861-4864 NNP denotes Raw
T10763 4865-4870 CD denotes 264.7
T10764 4871-4876 NNS denotes cells
T10765 4876-4877 . denotes .
T10766 4878-4881 PRP$ denotes Our
T10767 4882-4889 NNS denotes results
T10768 4890-4899 VBD denotes indicated
T10769 4900-4904 IN denotes that
T10770 4905-4909 NNP denotes PKCα
T10771 4910-4919 VBD denotes regulated
T10772 4920-4925 NNP denotes NF-κB
T10773 4926-4936 NN denotes activation
T10774 4937-4940 CC denotes and
T10775 4941-4956 JJ denotes M-CSF-regulated
T10776 4957-4961 NN denotes cell
T10777 4962-4970 NN denotes survival
T10778 4970-4971 . denotes .
T25475 1347-1351 NNP denotes PKCα
T25476 1352-1361 VBZ denotes regulates
T25477 1362-1377 NN denotes phosphorylation
T25478 1378-1380 IN denotes of
T25479 1381-1386 NNP denotes NF-κB
T25480 1387-1390 NNS denotes p65
T25481 1391-1393 IN denotes at
T25482 1394-1400 NNP denotes Ser276
T25483 1400-1401 . denotes .
T25484 1402-1403 -LRB- denotes (
T25485 1403-1404 NNP denotes A
T25486 1404-1405 -RRB- denotes )
T25487 1406-1409 NNP denotes MDM
T25488 1410-1412 CC denotes or
T25489 1413-1414 -LRB- denotes (
T25490 1414-1415 NNP denotes B
T25491 1415-1416 -RRB- denotes )
T25492 1417-1420 NNP denotes RAW
T25493 1421-1426 CD denotes 264.7
T25494 1427-1432 NNS denotes cells
T25495 1433-1437 VBD denotes were
T25496 1438-1449 RB denotes transiently
T25497 1450-1461 VBN denotes transfected
T25498 1462-1466 IN denotes with
T25499 1467-1478 JJ denotes pNF-κB-SEAP
T25500 1479-1484 IN denotes along
T25501 1485-1489 IN denotes with
T25502 1490-1496 DT denotes either
T25503 1497-1504 NNP denotes WT-PKCα
T25504 1505-1507 CC denotes or
T25505 1508-1511 DT denotes the
T25506 1512-1528 JJ denotes kinase-deficient
T25507 1529-1530 -LRB- denotes (
T25508 1530-1532 NNP denotes KD
T25509 1532-1533 -RRB- denotes )
T25510 1533-1534 : denotes -
T25511 1534-1538 NNP denotes PKCα
T25512 1539-1548 VB denotes construct
T25513 1549-1551 IN denotes at
T25514 1552-1553 DT denotes a
T25515 1554-1555 CD denotes 1
T25516 1555-1556 NN denotes ∶
T25517 1556-1557 CD denotes 5
T25518 1558-1563 NN denotes ratio
T25519 1563-1564 . denotes .
T25520 1565-1570 NNS denotes Cells
T25521 1571-1575 VBD denotes were
T25522 1576-1581 JJ denotes serum
T25523 1582-1589 VBN denotes starved
T25524 1590-1593 CC denotes and
T25525 1594-1604 VBN denotes stimulated
T25526 1605-1609 IN denotes with
T25527 1610-1615 NNP denotes M-CSF
T25528 1616-1619 CC denotes and
T25529 1620-1624 RB denotes then
T25530 1625-1629 NNP denotes SEAP
T25531 1630-1639 NN denotes secretion
T25532 1640-1642 IN denotes in
T25533 1643-1646 DT denotes the
T25534 1647-1653 NN denotes medium
T25535 1654-1657 VBD denotes was
T25536 1658-1666 VBN denotes measured
T25537 1666-1667 . denotes .
T25538 1668-1672 NNP denotes Data
T25539 1673-1675 VBZ denotes is
T25540 1676-1680 IN denotes from
T25541 1681-1683 IN denotes of
T25542 1684-1689 CD denotes three
T25543 1690-1701 JJ denotes independent
T25544 1702-1713 NNS denotes experiments
T25545 1713-1714 . denotes .
T25546 1715-1718 DT denotes The
T25547 1719-1726 NN denotes p-value
T25548 1727-1729 IN denotes of
T25549 1730-1735 NNS denotes cells
T25550 1736-1747 VBN denotes transfected
T25551 1748-1752 IN denotes with
T25552 1753-1755 NNP denotes KD
T25553 1756-1764 VBN denotes compared
T25554 1765-1767 TO denotes to
T25555 1768-1773 DT denotes those
T25556 1774-1785 VBN denotes transfected
T25557 1786-1790 IN denotes with
T25558 1791-1793 NNP denotes WT
T25559 1794-1797 VBD denotes was
T25560 1798-1802 CD denotes 0.05
T25561 1802-1803 . denotes .
T25562 1804-1805 -LRB- denotes (
T25563 1805-1806 $ denotes C
T25564 1806-1807 -RRB- denotes )
T25565 1808-1812 NNS denotes MDMs
T25566 1813-1817 VBD denotes were
T25567 1818-1825 VBN denotes removed
T25568 1826-1830 IN denotes from
T25569 1831-1834 DT denotes the
T25570 1835-1840 NN denotes plate
T25571 1841-1846 VBG denotes using
T25572 1847-1855 NN denotes accutase
T25573 1856-1859 CC denotes and
T25574 1860-1869 NN denotes apoptosis
T25575 1870-1872 IN denotes of
T25576 1873-1877 NNS denotes MDMs
T25577 1878-1881 VBD denotes was
T25578 1882-1890 VBN denotes measured
T25579 1891-1893 IN denotes by
T25580 1894-1898 NN denotes flow
T25581 1899-1908 NN denotes cytometry
T25582 1909-1914 VBG denotes using
T25583 1915-1922 NNP denotes Annexin
T25584 1923-1929 NNP denotes V-FITC
T25585 1930-1933 CC denotes and
T25586 1934-1943 NN denotes propidium
T25587 1944-1950 NN denotes iodine
T25588 1951-1952 -LRB- denotes (
T25589 1952-1954 NNP denotes PI
T25590 1954-1955 -RRB- denotes )
T25591 1955-1956 . denotes .
T25592 1957-1958 -LRB- denotes (
T25593 1958-1959 NNP denotes D
T25594 1959-1960 -RRB- denotes )
T25595 1961-1966 NNP denotes Whole
T25596 1967-1971 NN denotes cell
T25597 1972-1979 VBZ denotes lysates
T25598 1980-1984 IN denotes from
T25599 1985-1988 DT denotes the
T25600 1989-2000 VBN denotes transfected
T25601 2001-2004 NNP denotes RAW
T25602 2005-2010 CD denotes 264.7
T25603 2011-2016 NNS denotes cells
T25604 2017-2021 VBD denotes were
T25605 2022-2031 VBN denotes subjected
T25606 2032-2034 TO denotes to
T25607 2035-2042 JJ denotes Western
T25608 2043-2047 NN denotes blot
T25609 2048-2056 NN denotes analysis
T25610 2057-2061 IN denotes with
T25611 2062-2076 NN denotes phospho-Ser276
T25612 2077-2079 CC denotes or
T25613 2080-2094 NN denotes phospho-Ser536
T25614 2095-2100 NNP denotes NF-κB
T25615 2101-2104 CD denotes p65
T25616 2105-2115 NNS denotes antibodies
T25617 2115-2116 . denotes .
T25618 2117-2122 NNS denotes Blots
T25619 2123-2127 VBD denotes were
T25620 2128-2141 VBN denotes immunoblotted
T25621 2142-2146 IN denotes with
T25622 2147-2151 NNP denotes PKCα
T25623 2152-2154 TO denotes to
T25624 2155-2164 VB denotes determine
T25625 2165-2170 JJ denotes equal
T25626 2171-2178 NN denotes protein
T25627 2179-2189 NN denotes expression
T25628 2190-2193 IN denotes for
T25629 2194-2197 DT denotes the
T25630 2198-2202 NNP denotes PKCα
T25631 2203-2213 NNS denotes constructs
T25632 2213-2214 . denotes .
T25633 2215-2222 JJ denotes β-actin
T25634 2223-2229 VBD denotes served
T25635 2230-2232 IN denotes as
T25636 2233-2234 DT denotes a
T25637 2235-2242 VBG denotes loading
T25638 2243-2250 NN denotes control
T25639 2250-2251 . denotes .
T25640 2252-2257 VBN denotes Shown
T25641 2258-2260 VBZ denotes is
T25642 2261-2262 DT denotes a
T25643 2263-2277 JJ denotes representative
T25644 2278-2282 NN denotes blot
T25645 2283-2287 IN denotes from
T25646 2288-2293 CD denotes three
T25647 2294-2305 JJ denotes independent
T25648 2306-2317 NNS denotes experiments
T25649 2317-2318 . denotes .
T25650 2319-2320 -LRB- denotes (
T25651 2320-2321 NNP denotes E
T25652 2321-2322 -RRB- denotes )
T25653 2323-2326 NNP denotes MDM
T25654 2327-2329 CC denotes or
T25655 2330-2331 -LRB- denotes (
T25656 2331-2332 NN denotes F
T25657 2332-2333 -RRB- denotes )
T25658 2334-2337 NNP denotes RAW
T25659 2338-2343 CD denotes 264.7
T25660 2344-2349 NNS denotes cells
T25661 2350-2354 VBD denotes were
T25662 2355-2366 RB denotes transiently
T25663 2367-2378 VBN denotes transfected
T25664 2379-2383 IN denotes with
T25665 2384-2385 DT denotes a
T25666 2386-2397 JJ denotes pNF-κB-SEAP
T25667 2398-2403 IN denotes along
T25668 2404-2408 IN denotes with
T25669 2409-2415 DT denotes either
T25670 2416-2419 CD denotes 100
T25671 2420-2422 NNP denotes nM
T25672 2423-2427 NNP denotes PKCα
T25673 2428-2433 NNP denotes siRNA
T25674 2434-2436 CC denotes or
T25675 2437-2444 VB denotes control
T25676 2445-2450 NNP denotes siRNA
T25677 2451-2454 IN denotes for
T25678 2455-2460 CD denotes 20-24
T25679 2461-2466 NNS denotes hours
T25680 2466-2467 . denotes .
T25681 2468-2473 NNS denotes Cells
T25682 2474-2478 VBD denotes were
T25683 2479-2484 JJ denotes serum
T25684 2485-2492 VBN denotes starved
T25685 2493-2496 IN denotes for
T25686 2497-2500 CD denotes 2-4
T25687 2501-2506 NNS denotes hours
T25688 2507-2510 CC denotes and
T25689 2511-2521 VBN denotes stimulated
T25690 2522-2526 IN denotes with
T25691 2527-2530 CD denotes 100
T25692 2531-2536 JJ denotes ng/ml
T25693 2537-2542 NN denotes M-CSF
T25694 2543-2546 IN denotes for
T25695 2547-2548 CD denotes 6
T25696 2549-2554 NNS denotes hours
T25697 2555-2558 IN denotes for
T25698 2559-2562 NNP denotes MDM
T25699 2563-2565 CC denotes or
T25700 2566-2569 NNP denotes RAW
T25701 2570-2575 CD denotes 264.7
T25702 2576-2579 IN denotes for
T25703 2580-2581 CD denotes 2
T25704 2582-2587 NNS denotes hours
T25705 2588-2591 CC denotes and
T25706 2592-2596 RB denotes then
T25707 2597-2601 NNP denotes SEAP
T25708 2602-2611 NN denotes secretion
T25709 2612-2614 IN denotes in
T25710 2615-2618 DT denotes the
T25711 2619-2625 NN denotes medium
T25712 2626-2629 VBD denotes was
T25713 2630-2638 VBN denotes measured
T25714 2638-2639 . denotes .
T25715 2640-2645 VBN denotes Shown
T25716 2646-2648 VBZ denotes is
T25717 2649-2653 NNS denotes data
T25718 2654-2656 IN denotes of
T25719 2657-2662 CD denotes three
T25720 2663-2674 JJ denotes independent
T25721 2675-2686 NNS denotes experiments
T25722 2686-2687 . denotes .
T25723 2688-2689 -LRB- denotes (
T25724 2689-2690 NNP denotes G
T25725 2690-2691 -RRB- denotes )
T25726 2692-2696 NNS denotes MDMs
T25727 2697-2701 VBD denotes were
T25728 2702-2709 VBN denotes removed
T25729 2710-2714 IN denotes from
T25730 2715-2718 DT denotes the
T25731 2719-2724 NN denotes plate
T25732 2725-2730 VBG denotes using
T25733 2731-2739 NN denotes accutase
T25734 2740-2743 CC denotes and
T25735 2744-2753 NN denotes apoptosis
T25736 2754-2756 IN denotes of
T25737 2757-2761 NNS denotes MDMs
T25738 2762-2765 VBD denotes was
T25739 2766-2774 VBN denotes measured
T25740 2775-2777 IN denotes by
T25741 2778-2785 NNP denotes Annexin
T25742 2786-2792 NNP denotes V-FITC
T25743 2793-2796 CC denotes and
T25744 2797-2806 NN denotes propidium
T25745 2807-2813 NN denotes iodine
T25746 2814-2815 -LRB- denotes (
T25747 2815-2817 NNP denotes PI
T25748 2817-2818 -RRB- denotes )
T25749 2819-2827 VBG denotes staining
T25750 2828-2831 CC denotes and
T25751 2832-2840 VBN denotes analyzed
T25752 2841-2843 IN denotes by
T25753 2844-2848 NN denotes flow
T25754 2849-2858 NN denotes cytometry
T25755 2858-2859 . denotes .
T25756 2860-2861 -LRB- denotes (
T25757 2861-2862 NNP denotes H
T25758 2862-2863 -RRB- denotes )
T25759 2864-2869 NNP denotes Whole
T25760 2870-2874 NN denotes cell
T25761 2875-2882 VBZ denotes lysates
T25762 2883-2887 IN denotes from
T25763 2888-2891 DT denotes the
T25764 2892-2903 VBN denotes transfected
T25765 2904-2907 NNP denotes MDM
T25766 2908-2911 CC denotes and
T25767 2912-2915 NNP denotes RAW
T25768 2916-2921 CD denotes 264.7
T25769 2922-2927 NNS denotes cells
T25770 2928-2932 VBD denotes were
T25771 2933-2942 VBN denotes subjected
T25772 2943-2945 TO denotes to
T25773 2946-2953 JJ denotes Western
T25774 2954-2958 NN denotes blot
T25775 2959-2967 NN denotes analysis
T25776 2968-2972 IN denotes with
T25777 2973-2977 NNP denotes PKCα
T25778 2978-2986 NN denotes antibody
T25779 2986-2987 . denotes .
T25780 2988-2995 JJ denotes β-actin
T25781 2996-3002 VBD denotes served
T25782 3003-3005 IN denotes as
T25783 3006-3007 DT denotes a
T25784 3008-3015 VBG denotes loading
T25785 3016-3023 NN denotes control
T25786 3023-3024 . denotes .
T25787 3025-3030 VBN denotes Shown
T25788 3031-3033 VBZ denotes is
T25789 3034-3035 DT denotes a
T25790 3036-3050 JJ denotes representative
T25791 3051-3055 NN denotes blot
T25792 3056-3060 IN denotes from
T25793 3061-3063 IN denotes at
T25794 3064-3069 JJS denotes least
T25795 3070-3075 CD denotes three
T25796 3076-3087 JJ denotes independent
T25797 3088-3099 NNS denotes experiments
T25798 3099-3100 . denotes .
R7626 T10239 T10276 nsubj Identification,suggested
R7627 T10240 T10239 prep of,Identification
R7628 T10241 T10240 pobj PKCα,of
R7629 T10242 T10239 prep as,Identification
R7630 T10243 T10245 det the,Activator
R7631 T10244 T10245 compound Upstream,Activator
R7632 T10245 T10242 pobj Activator,as
R7633 T10246 T10245 prep of,Activator
R7634 T10247 T10246 pobj NF-κB,of
R7635 T10248 T10245 prep in,Activator
R7636 T10249 T10250 compound Myeloid,Cells
R7637 T10250 T10248 pobj Cells,in
R7638 T10251 T10256 advmod Even,consists
R7639 T10252 T10256 mark though,consists
R7640 T10253 T10255 det the,family
R7641 T10254 T10255 compound PKC,family
R7642 T10255 T10256 nsubj family,consists
R7643 T10256 T10276 advcl consists,suggested
R7644 T10257 T10256 prep of,consists
R7645 T10258 T10259 nummod 10,members
R7646 T10259 T10257 pobj members,of
R7647 T10260 T10256 punct ",",consists
R7648 T10261 T10256 advcl finding,consists
R7649 T10262 T10265 mark that,β
R7650 T10263 T10265 nsubj PKCα,β
R7651 T10264 T10265 compound /,β
R7652 T10265 T10261 ccomp β,finding
R7653 T10266 T10265 dobj inhibitors,β
R7654 T10267 T10266 cc and,inhibitors
R7655 T10268 T10270 amod intracellular,inhibitors
R7656 T10269 T10270 compound calcium,inhibitors
R7657 T10270 T10266 conj inhibitors,inhibitors
R7658 T10271 T10265 conj reduced,β
R7659 T10272 T10274 amod M-CSF-induced,activity
R7660 T10273 T10274 compound NF-κB,activity
R7661 T10274 T10271 dobj activity,reduced
R7662 T10275 T10276 punct ",",suggested
R7663 T10276 T10276 ROOT suggested,suggested
R7664 T10277 T10279 nsubjpass PKCα,involved
R7665 T10278 T10279 auxpass was,involved
R7666 T10279 T10276 ccomp involved,suggested
R7667 T10280 T10279 prep in,involved
R7668 T10281 T10282 amod NF-κB,activation
R7669 T10282 T10280 pobj activation,in
R7670 T10283 T10282 prep after,activation
R7671 T10284 T10285 compound M-CSF,treatment
R7672 T10285 T10283 pobj treatment,after
R7673 T10286 T10276 punct .,suggested
R7674 T10287 T10288 aux To,confirm
R7675 T10288 T10316 advcl confirm,co-transfected
R7676 T10289 T10290 det the,role
R7677 T10290 T10288 dobj role,confirm
R7678 T10291 T10290 prep of,role
R7679 T10292 T10291 pobj PKCα,of
R7680 T10293 T10292 prep in,PKCα
R7681 T10294 T10295 compound NF-κB,activation
R7682 T10295 T10293 pobj activation,in
R7683 T10296 T10295 prep in,activation
R7684 T10297 T10296 pobj macrophages,in
R7685 T10298 T10290 punct ",",role
R7686 T10299 T10290 conj constructs,role
R7687 T10300 T10290 prep for,role
R7688 T10301 T10302 det either,wildtype
R7689 T10302 T10300 pobj wildtype,for
R7690 T10303 T10302 punct (,wildtype
R7691 T10304 T10302 appos WT,wildtype
R7692 T10305 T10304 punct ),WT
R7693 T10306 T10302 punct -,wildtype
R7694 T10307 T10302 conj PKCα,wildtype
R7695 T10308 T10307 cc or,PKCα
R7696 T10309 T10307 conj kinase-deficient,PKCα
R7697 T10310 T10311 punct (,KD
R7698 T10311 T10302 appos KD,wildtype
R7699 T10312 T10311 punct ),KD
R7700 T10313 T10314 punct -,PKCα
R7701 T10314 T10315 nsubj PKCα,was
R7702 T10315 T10316 auxpass was,co-transfected
R7703 T10316 T10316 ROOT co-transfected,co-transfected
R7704 T10317 T10316 prep with,co-transfected
R7705 T10318 T10321 det the,gene
R7706 T10319 T10321 amod pNF-κB-SEAP,gene
R7707 T10320 T10321 compound reporter,gene
R7708 T10321 T10317 pobj gene,with
R7709 T10322 T10321 cc and,gene
R7710 T10323 T10324 compound SEAP,secretion
R7711 T10324 T10321 conj secretion,gene
R7712 T10325 T10326 auxpass was,measured
R7713 T10326 T10316 conj measured,co-transfected
R7714 T10327 T10316 punct .,co-transfected
R7715 T10328 T10329 mark As,shown
R7716 T10329 T10335 advcl shown,co-transfected
R7717 T10330 T10329 prep in,shown
R7718 T10331 T10332 compound Figure,7A
R7719 T10332 T10330 pobj 7A,in
R7720 T10333 T10335 punct ",",co-transfected
R7721 T10334 T10335 nsubj MDMs,co-transfected
R7722 T10335 T10335 ROOT co-transfected,co-transfected
R7723 T10336 T10335 prep with,co-transfected
R7724 T10337 T10336 pobj pNF-κB-SEAP,with
R7725 T10338 T10337 cc and,pNF-κB-SEAP
R7726 T10339 T10337 conj WT-PKCα,pNF-κB-SEAP
R7727 T10340 T10335 conj had,co-transfected
R7728 T10341 T10343 det a,increase
R7729 T10342 T10343 amod 1.8-fold,increase
R7730 T10343 T10340 dobj increase,had
R7731 T10344 T10343 prep in,increase
R7732 T10345 T10347 amod NF-κB,activity
R7733 T10346 T10347 amod transcriptional,activity
R7734 T10347 T10344 pobj activity,in
R7735 T10348 T10343 prep after,increase
R7736 T10349 T10350 compound M-CSF,activation
R7737 T10350 T10348 pobj activation,after
R7738 T10351 T10343 prep compared,increase
R7739 T10352 T10351 prep with,compared
R7740 T10353 T10354 compound NS,cells
R7741 T10354 T10352 pobj cells,with
R7742 T10355 T10354 punct (,cells
R7743 T10356 T10354 appos p,cells
R7744 T10357 T10358 punct =,0.05
R7745 T10358 T10356 prep 0.05,p
R7746 T10359 T10354 punct ),cells
R7747 T10360 T10354 punct ",",cells
R7748 T10361 T10354 amod similar,cells
R7749 T10362 T10361 prep to,similar
R7750 T10363 T10364 amod M-CSF-treated,cells
R7751 T10364 T10362 pobj cells,to
R7752 T10365 T10364 acl expressing,cells
R7753 T10366 T10367 advmod only,pNF-κB-SEAP
R7754 T10367 T10365 dobj pNF-κB-SEAP,expressing
R7755 T10368 T10335 punct .,co-transfected
R7756 T10369 T10369 ROOT Transfecting,Transfecting
R7757 T10370 T10371 amod human,macrophages
R7758 T10371 T10369 dobj macrophages,Transfecting
R7759 T10372 T10369 prep with,Transfecting
R7760 T10373 T10374 det the,KD-PKCα
R7761 T10374 T10372 pobj KD-PKCα,with
R7762 T10375 T10369 nsubj construct,Transfecting
R7763 T10376 T10377 advmod significantly,reduced
R7764 T10377 T10380 amod reduced,activity
R7765 T10378 T10380 amod M-CSF-induced,activity
R7766 T10379 T10380 compound NF-κB,activity
R7767 T10380 T10375 dobj activity,construct
R7768 T10381 T10375 prep compared,construct
R7769 T10382 T10381 prep to,compared
R7770 T10383 T10385 amod WT-PKCα,cells
R7771 T10384 T10385 amod transfected,cells
R7772 T10385 T10382 pobj cells,to
R7773 T10386 T10385 punct (,cells
R7774 T10387 T10385 appos p,cells
R7775 T10388 T10389 punct =,0.016
R7776 T10389 T10387 pobj 0.016,p
R7777 T10390 T10385 punct ),cells
R7778 T10391 T10369 punct .,Transfecting
R7779 T10392 T10397 advmod Similarly,transfected
R7780 T10393 T10397 punct ",",transfected
R7781 T10394 T10397 nsubj RAW,transfected
R7782 T10395 T10396 nummod 264.7,cells
R7783 T10396 T10397 compound cells,transfected
R7784 T10397 T10397 ROOT transfected,transfected
R7785 T10398 T10397 prep with,transfected
R7786 T10399 T10398 pobj WT-PKCα,with
R7787 T10400 T10397 conj had,transfected
R7788 T10401 T10405 nummod 2.5-fold,activity
R7789 T10402 T10401 amod more,2.5-fold
R7790 T10403 T10405 amod NF-κB,activity
R7791 T10404 T10405 compound transcriptional,activity
R7792 T10405 T10400 dobj activity,had
R7793 T10406 T10400 prep after,had
R7794 T10407 T10408 compound M-CSF,activation
R7795 T10408 T10406 pobj activation,after
R7796 T10409 T10400 prep compared,had
R7797 T10410 T10409 prep to,compared
R7798 T10411 T10412 compound unstimulated,RAW
R7799 T10412 T10410 pobj RAW,to
R7800 T10413 T10414 nummod 264.7,cells
R7801 T10414 T10412 dobj cells,RAW
R7802 T10415 T10416 punct (,NS
R7803 T10416 T10414 appos NS,cells
R7804 T10417 T10400 punct ),had
R7805 T10418 T10418 ROOT transfected,transfected
R7806 T10419 T10418 prep with,transfected
R7807 T10420 T10419 pobj WT-PKCα,with
R7808 T10421 T10423 punct (,7B
R7809 T10422 T10423 compound Figure,7B
R7810 T10423 T10420 appos 7B,WT-PKCα
R7811 T10424 T10423 punct ),7B
R7812 T10425 T10418 punct .,transfected
R7813 T10426 T10430 nsubj Expression,construct
R7814 T10427 T10426 prep of,Expression
R7815 T10428 T10429 det the,KD-PKCα
R7816 T10429 T10427 pobj KD-PKCα,of
R7817 T10430 T10430 ROOT construct,construct
R7818 T10431 T10430 prep into,construct
R7819 T10432 T10431 pobj RAW,into
R7820 T10433 T10434 nummod 264.7,cells
R7821 T10434 T10446 nsubj cells,compared
R7822 T10435 T10434 acl reduced,cells
R7823 T10436 T10438 amod M-CSF-induced,activity
R7824 T10437 T10438 compound NF-κB,activity
R7825 T10438 T10435 dobj activity,reduced
R7826 T10439 T10435 prep to,reduced
R7827 T10440 T10439 pobj 1.5-fold,to
R7828 T10441 T10440 punct (,1.5-fold
R7829 T10442 T10440 appos p,1.5-fold
R7830 T10443 T10444 punct =,0.045
R7831 T10444 T10442 nummod 0.045,p
R7832 T10445 T10440 punct ),1.5-fold
R7833 T10446 T10430 prep compared,construct
R7834 T10447 T10446 prep to,compared
R7835 T10448 T10447 pobj cells,to
R7836 T10449 T10448 acl transfected,cells
R7837 T10450 T10449 prep with,transfected
R7838 T10451 T10452 compound WT,PKCα
R7839 T10452 T10450 pobj PKCα,with
R7840 T10453 T10430 punct .,construct
R7841 T10454 T10455 compound Cell,survival
R7842 T10455 T10458 nsubjpass survival,examined
R7843 T10456 T10458 auxpass was,examined
R7844 T10457 T10458 advmod also,examined
R7845 T10458 T10458 ROOT examined,examined
R7846 T10459 T10458 prep in,examined
R7847 T10460 T10459 pobj MDMs,in
R7848 T10461 T10460 acl expressing,MDMs
R7849 T10462 T10463 preconj either,WT-PKCα
R7850 T10463 T10461 dobj WT-PKCα,expressing
R7851 T10464 T10463 cc or,WT-PKCα
R7852 T10465 T10463 conj KD-PKCα,WT-PKCα
R7853 T10466 T10463 conj constructs,WT-PKCα
R7854 T10467 T10461 prep by,expressing
R7855 T10468 T10469 compound Annexin,V-FITC
R7856 T10469 T10467 pobj V-FITC,by
R7857 T10470 T10469 cc and,V-FITC
R7858 T10471 T10469 conj PI,V-FITC
R7859 T10472 T10458 advcl staining,examined
R7860 T10473 T10458 punct .,examined
R7861 T10474 T10475 mark As,expected
R7862 T10475 T10478 advcl expected,increased
R7863 T10476 T10478 punct ",",increased
R7864 T10477 T10478 nsubj M-CSF,increased
R7865 T10478 T10478 ROOT increased,increased
R7866 T10479 T10480 compound MDM,survival
R7867 T10480 T10478 dobj survival,increased
R7868 T10481 T10482 mark as,measured
R7869 T10482 T10478 advcl measured,increased
R7870 T10483 T10482 agent by,measured
R7871 T10484 T10485 det the,percent
R7872 T10485 T10483 pobj percent,by
R7873 T10486 T10485 prep of,percent
R7874 T10487 T10488 compound Annexin,V/PI
R7875 T10488 T10490 nmod V/PI,cells
R7876 T10489 T10490 amod negative,cells
R7877 T10490 T10486 pobj cells,of
R7878 T10491 T10478 punct .,increased
R7879 T10492 T10494 advmod Similarly,expression
R7880 T10493 T10494 punct ",",expression
R7881 T10494 T10494 ROOT expression,expression
R7882 T10495 T10494 prep of,expression
R7883 T10496 T10498 amod WT-PKCα,cells
R7884 T10497 T10498 amod protected,cells
R7885 T10498 T10495 pobj cells,of
R7886 T10499 T10498 prep from,cells
R7887 T10500 T10499 pobj apoptosis,from
R7888 T10501 T10494 punct .,expression
R7889 T10502 T10508 prep In,decreased
R7890 T10503 T10502 pobj contrast,In
R7891 T10504 T10508 punct ",",decreased
R7892 T10505 T10508 nsubj expression,decreased
R7893 T10506 T10505 prep of,expression
R7894 T10507 T10506 pobj KD-PKCα,of
R7895 T10508 T10508 ROOT decreased,decreased
R7896 T10509 T10511 amod M-CSF-induced,survival
R7897 T10510 T10511 compound cell,survival
R7898 T10511 T10508 dobj survival,decreased
R7899 T10512 T10511 punct (,survival
R7900 T10513 T10514 advmod p,<
R7901 T10514 T10515 nmod <,0.01
R7902 T10515 T10511 appos 0.01,survival
R7903 T10516 T10511 punct ),survival
R7904 T10517 T10519 punct (,7C
R7905 T10518 T10519 compound Figure,7C
R7906 T10519 T10511 appos 7C,survival
R7907 T10520 T10508 punct ),decreased
R7908 T10521 T10508 punct .,decreased
R7909 T10522 T10525 advmod Next,examined
R7910 T10523 T10525 punct ",",examined
R7911 T10524 T10525 nsubj we,examined
R7912 T10525 T10525 ROOT examined,examined
R7913 T10526 T10527 det the,effect
R7914 T10527 T10525 dobj effect,examined
R7915 T10528 T10527 prep of,effect
R7916 T10529 T10528 pcomp expressing,of
R7917 T10530 T10532 det the,constructs
R7918 T10531 T10532 nsubj PKCα,constructs
R7919 T10532 T10529 dobj constructs,expressing
R7920 T10533 T10532 prep on,constructs
R7921 T10534 T10535 amod NF-κB,phosphorylation
R7922 T10535 T10533 pobj phosphorylation,on
R7923 T10536 T10525 punct .,examined
R7924 T10537 T10538 mark As,shown
R7925 T10538 T10552 advcl shown,affect
R7926 T10539 T10538 prep in,shown
R7927 T10540 T10539 pobj Figure,in
R7928 T10541 T10540 nummod 7D,Figure
R7929 T10542 T10540 punct ",",Figure
R7930 T10543 T10538 dobj expression,shown
R7931 T10544 T10543 prep of,expression
R7932 T10545 T10544 pobj KD-PKCα,of
R7933 T10546 T10545 prep in,KD-PKCα
R7934 T10547 T10546 pobj RAW,in
R7935 T10548 T10549 nummod 264.7,cells
R7936 T10549 T10544 pobj cells,of
R7937 T10550 T10552 aux did,affect
R7938 T10551 T10552 neg not,affect
R7939 T10552 T10552 ROOT affect,affect
R7940 T10553 T10555 det the,phosphorylation
R7941 T10554 T10555 amod constitutive,phosphorylation
R7942 T10555 T10552 dobj phosphorylation,affect
R7943 T10556 T10555 prep at,phosphorylation
R7944 T10557 T10556 pobj Ser536,at
R7945 T10558 T10557 prep of,Ser536
R7946 T10559 T10558 pobj NF-κB,of
R7947 T10560 T10559 nummod p65,NF-κB
R7948 T10561 T10552 punct ",",affect
R7949 T10562 T10552 cc but,affect
R7950 T10563 T10552 conj attenuated,affect
R7951 T10564 T10565 det the,phosphorylation
R7952 T10565 T10563 dobj phosphorylation,attenuated
R7953 T10566 T10563 prep at,attenuated
R7954 T10567 T10566 pobj Ser276,at
R7955 T10568 T10552 punct .,affect
R7956 T10569 T10574 nsubj Expression,effect
R7957 T10570 T10569 prep of,Expression
R7958 T10571 T10570 pobj WT-PKCα,of
R7959 T10572 T10574 aux did,effect
R7960 T10573 T10574 neg not,effect
R7961 T10574 T10574 ROOT effect,effect
R7962 T10575 T10576 det the,phosphorylation
R7963 T10576 T10574 dobj phosphorylation,effect
R7964 T10577 T10576 prep of,phosphorylation
R7965 T10578 T10579 det either,residue
R7966 T10579 T10577 pobj residue,of
R7967 T10580 T10576 prep with,phosphorylation
R7968 T10581 T10580 cc or,with
R7969 T10582 T10580 conj without,with
R7970 T10583 T10584 compound M-CSF,stimulation
R7971 T10584 T10582 pobj stimulation,without
R7972 T10585 T10574 punct .,effect
R7973 T10586 T10587 det These,observations
R7974 T10587 T10588 nsubj observations,demonstrate
R7975 T10588 T10588 ROOT demonstrate,demonstrate
R7976 T10589 T10591 mark that,is
R7977 T10590 T10591 nsubj PKCα,is
R7978 T10591 T10588 ccomp is,demonstrate
R7979 T10592 T10591 acomp important,is
R7980 T10593 T10592 prep in,important
R7981 T10594 T10596 amod M-CSF-regulated,survival
R7982 T10595 T10596 compound cell,survival
R7983 T10596 T10593 pobj survival,in
R7984 T10597 T10596 cc and,survival
R7985 T10598 T10599 amod NF-κB,activation
R7986 T10599 T10596 conj activation,survival
R7987 T10600 T10599 cc and,activation
R7988 T10601 T10602 advmod likely,regulated
R7989 T10602 T10591 conj regulated,is
R7990 T10603 T10602 prep through,regulated
R7991 T10604 T10603 pobj phosphorylation,through
R7992 T10605 T10604 prep of,phosphorylation
R7993 T10606 T10605 pobj Ser276,of
R7994 T10607 T10606 prep of,Ser276
R7995 T10608 T10609 compound NF-κB,p65
R7996 T10609 T10607 pobj p65,of
R7997 T10610 T10588 punct .,demonstrate
R7998 T10611 T10613 aux To,validate
R7999 T10612 T10613 advmod further,validate
R8000 T10613 T10627 advcl validate,employed
R8001 T10614 T10615 det the,impact
R8002 T10615 T10613 dobj impact,validate
R8003 T10616 T10618 dobj that,played
R8004 T10617 T10618 nsubj PKCα,played
R8005 T10618 T10615 relcl played,impact
R8006 T10619 T10618 prep in,played
R8007 T10620 T10623 amod M-CSF-induced,activity
R8008 T10621 T10623 nmod NF-κB,activity
R8009 T10622 T10623 compound transcriptional,activity
R8010 T10623 T10619 pobj activity,in
R8011 T10624 T10627 punct ",",employed
R8012 T10625 T10627 nsubj we,employed
R8013 T10626 T10627 advmod next,employed
R8014 T10627 T10627 ROOT employed,employed
R8015 T10628 T10629 compound PKCα,siRNA
R8016 T10629 T10630 compound siRNA,treatment
R8017 T10630 T10627 dobj treatment,employed
R8018 T10631 T10630 prep of,treatment
R8019 T10632 T10635 nmod MDM,cells
R8020 T10633 T10632 cc or,MDM
R8021 T10634 T10632 conj RAW,MDM
R8022 T10635 T10631 pobj cells,of
R8023 T10636 T10627 punct .,employed
R8024 T10637 T10638 det A,pool
R8025 T10638 T10644 nsubjpass pool,transfected
R8026 T10639 T10638 prep of,pool
R8027 T10640 T10642 amod specific,siRNA
R8028 T10641 T10642 compound PKCα,siRNA
R8029 T10642 T10639 pobj siRNA,of
R8030 T10643 T10644 auxpass were,transfected
R8031 T10644 T10644 ROOT transfected,transfected
R8032 T10645 T10644 prep into,transfected
R8033 T10646 T10645 pobj MDM,into
R8034 T10647 T10646 cc or,MDM
R8035 T10648 T10646 conj Raw,MDM
R8036 T10649 T10650 nummod 264.7,cells
R8037 T10650 T10644 conj cells,transfected
R8038 T10651 T10650 prep in,cells
R8039 T10652 T10653 det the,presence
R8040 T10653 T10651 pobj presence,in
R8041 T10654 T10653 cc or,presence
R8042 T10655 T10653 conj absence,presence
R8043 T10656 T10655 cc or,absence
R8044 T10657 T10655 conj M-CSF,absence
R8045 T10658 T10644 punct .,transfected
R8046 T10659 T10663 advcl Reducing,decreased
R8047 T10660 T10662 amod native,expression
R8048 T10661 T10662 compound PKCα,expression
R8049 T10662 T10659 dobj expression,Reducing
R8050 T10663 T10663 ROOT decreased,decreased
R8051 T10664 T10667 amod M-CSF-induced,activity
R8052 T10665 T10667 nmod NF-κB,activity
R8053 T10666 T10667 compound transcriptional,activity
R8054 T10667 T10663 dobj activity,decreased
R8055 T10668 T10663 prep in,decreased
R8056 T10669 T10673 det both,7E
R8057 T10670 T10673 compound MDM,7E
R8058 T10671 T10672 punct (,Figure
R8059 T10672 T10673 compound Figure,7E
R8060 T10673 T10668 pobj 7E,in
R8061 T10674 T10663 punct ),decreased
R8062 T10675 T10676 punct (,p
R8063 T10676 T10676 ROOT p,p
R8064 T10677 T10678 punct =,0.012
R8065 T10678 T10676 prep 0.012,p
R8066 T10679 T10676 punct ),p
R8067 T10680 T10676 cc and,p
R8068 T10681 T10683 nmod Raw,cells
R8069 T10682 T10683 nummod 264.7,cells
R8070 T10683 T10689 nmod cells,p
R8071 T10684 T10685 punct (,Figure
R8072 T10685 T10683 appos Figure,cells
R8073 T10686 T10685 nummod 7F,Figure
R8074 T10687 T10683 punct ),cells
R8075 T10688 T10683 punct (,cells
R8076 T10689 T10676 conj p,p
R8077 T10690 T10691 punct =,0.01
R8078 T10691 T10689 prep 0.01,p
R8079 T10692 T10689 punct ),p
R8080 T10693 T10663 punct .,decreased
R8081 T10694 T10696 nsubj We,examined
R8082 T10695 T10696 advmod also,examined
R8083 T10696 T10696 ROOT examined,examined
R8084 T10697 T10698 compound cell,survival
R8085 T10698 T10696 dobj survival,examined
R8086 T10699 T10698 prep of,survival
R8087 T10700 T10701 det the,MDMs
R8088 T10701 T10699 pobj MDMs,of
R8089 T10702 T10696 prep by,examined
R8090 T10703 T10704 compound Annexin,V-FITC
R8091 T10704 T10702 pobj V-FITC,by
R8092 T10705 T10704 cc and,V-FITC
R8093 T10706 T10704 conj PI,V-FITC
R8094 T10707 T10696 advcl staining,examined
R8095 T10708 T10707 advmod after,staining
R8096 T10709 T10711 compound PKCα,transfection
R8097 T10710 T10711 compound siRNA,transfection
R8098 T10711 T10708 pobj transfection,after
R8099 T10712 T10696 punct .,examined
R8100 T10713 T10714 mark As,shown
R8101 T10714 T10714 ROOT shown,shown
R8102 T10715 T10714 prep in,shown
R8103 T10716 T10721 nmod Figure,survival
R8104 T10717 T10716 nummod 7G,Figure
R8105 T10718 T10716 punct ",",Figure
R8106 T10719 T10721 amod M-CSF-induced,survival
R8107 T10720 T10721 compound MDM,survival
R8108 T10721 T10715 pobj survival,in
R8109 T10722 T10723 auxpass was,reduced
R8110 T10723 T10714 conj reduced,shown
R8111 T10724 T10723 prep in,reduced
R8112 T10725 T10726 det the,cells
R8113 T10726 T10724 pobj cells,in
R8114 T10727 T10723 conj transfected,reduced
R8115 T10728 T10727 prep with,transfected
R8116 T10729 T10730 compound PKCα,siRNA
R8117 T10730 T10728 pobj siRNA,with
R8118 T10731 T10727 prep compared,transfected
R8119 T10732 T10731 prep with,compared
R8120 T10733 T10732 pobj cells,with
R8121 T10734 T10733 acl transfected,cells
R8122 T10735 T10734 prep with,transfected
R8123 T10736 T10737 compound control,siRNA
R8124 T10737 T10735 pobj siRNA,with
R8125 T10738 T10737 punct (,siRNA
R8126 T10739 T10737 parataxis p,siRNA
R8127 T10740 T10741 punct =,0.047
R8128 T10741 T10739 prep 0.047,p
R8129 T10742 T10737 punct ),siRNA
R8130 T10743 T10714 punct .,shown
R8131 T10744 T10749 prep In,confirmed
R8132 T10745 T10744 pobj Figure,In
R8133 T10746 T10745 nummod 7H,Figure
R8134 T10747 T10749 punct ",",confirmed
R8135 T10748 T10749 nsubj we,confirmed
R8136 T10749 T10749 ROOT confirmed,confirmed
R8137 T10750 T10754 mark that,decreased
R8138 T10751 T10753 compound PKCα,transfection
R8139 T10752 T10753 compound siRNA,transfection
R8140 T10753 T10754 nsubj transfection,decreased
R8141 T10754 T10749 ccomp decreased,confirmed
R8142 T10755 T10757 compound PKCα,expression
R8143 T10756 T10757 compound protein,expression
R8144 T10757 T10754 dobj expression,decreased
R8145 T10758 T10754 prep in,decreased
R8146 T10759 T10760 det both,MDM
R8147 T10760 T10764 nmod MDM,cells
R8148 T10761 T10760 cc and,MDM
R8149 T10762 T10760 conj Raw,MDM
R8150 T10763 T10764 nummod 264.7,cells
R8151 T10764 T10758 pobj cells,in
R8152 T10765 T10749 punct .,confirmed
R8153 T10766 T10767 poss Our,results
R8154 T10767 T10768 nsubj results,indicated
R8155 T10768 T10768 ROOT indicated,indicated
R8156 T10769 T10771 mark that,regulated
R8157 T10770 T10771 nsubj PKCα,regulated
R8158 T10771 T10768 ccomp regulated,indicated
R8159 T10772 T10773 compound NF-κB,activation
R8160 T10773 T10771 dobj activation,regulated
R8161 T10774 T10773 cc and,activation
R8162 T10775 T10777 amod M-CSF-regulated,survival
R8163 T10776 T10777 compound cell,survival
R8164 T10777 T10773 conj survival,activation
R8165 T10778 T10768 punct .,indicated
R19429 T25475 T25476 nsubj PKCα,regulates
R19430 T25476 T25476 ROOT regulates,regulates
R19431 T25477 T25476 dobj phosphorylation,regulates
R19432 T25478 T25477 prep of,phosphorylation
R19433 T25479 T25480 compound NF-κB,p65
R19434 T25480 T25478 pobj p65,of
R19435 T25481 T25476 prep at,regulates
R19436 T25482 T25481 pobj Ser276,at
R19437 T25483 T25476 punct .,regulates
R19438 T25484 T25497 punct (,transfected
R19439 T25485 T25494 nmod A,cells
R19440 T25486 T25485 punct ),A
R19441 T25487 T25485 conj MDM,A
R19442 T25488 T25487 cc or,MDM
R19443 T25489 T25490 punct (,B
R19444 T25490 T25492 nmod B,RAW
R19445 T25491 T25492 punct ),RAW
R19446 T25492 T25487 conj RAW,MDM
R19447 T25493 T25494 nummod 264.7,cells
R19448 T25494 T25497 nsubjpass cells,transfected
R19449 T25495 T25497 auxpass were,transfected
R19450 T25496 T25497 advmod transiently,transfected
R19451 T25497 T25497 ROOT transfected,transfected
R19452 T25498 T25497 prep with,transfected
R19453 T25499 T25512 advcl pNF-κB-SEAP,construct
R19454 T25500 T25499 prep along,pNF-κB-SEAP
R19455 T25501 T25500 prep with,along
R19456 T25502 T25503 det either,WT-PKCα
R19457 T25503 T25501 pobj WT-PKCα,with
R19458 T25504 T25503 cc or,WT-PKCα
R19459 T25505 T25506 det the,kinase-deficient
R19460 T25506 T25512 nsubj kinase-deficient,construct
R19461 T25507 T25508 punct (,KD
R19462 T25508 T25506 appos KD,kinase-deficient
R19463 T25509 T25508 punct ),KD
R19464 T25510 T25511 punct -,PKCα
R19465 T25511 T25506 appos PKCα,kinase-deficient
R19466 T25512 T25497 advcl construct,transfected
R19467 T25513 T25512 prep at,construct
R19468 T25514 T25518 det a,ratio
R19469 T25515 T25518 nummod 1,ratio
R19470 T25516 T25518 nmod ∶,ratio
R19471 T25517 T25516 nummod 5,∶
R19472 T25518 T25513 pobj ratio,at
R19473 T25519 T25497 punct .,transfected
R19474 T25520 T25523 nsubjpass Cells,starved
R19475 T25521 T25523 auxpass were,starved
R19476 T25522 T25523 advmod serum,starved
R19483 T25529 T25531 advmod then,secretion
R19484 T25530 T25531 compound SEAP,secretion
R19485 T25531 T25536 nsubjpass secretion,measured
R19486 T25532 T25531 prep in,secretion
R19487 T25533 T25534 det the,medium
R19488 T25534 T25532 pobj medium,in
R19489 T25535 T25536 auxpass was,measured
R19490 T25536 T25525 conj measured,stimulated
R19491 T25537 T25536 punct .,measured
R19492 T25538 T25539 nsubj Data,is
R19493 T25539 T25539 ROOT is,is
R19494 T25540 T25539 prep from,is
R19495 T25541 T25540 prep of,from
R19496 T25542 T25544 nummod three,experiments
R19497 T25543 T25544 amod independent,experiments
R19498 T25544 T25541 pobj experiments,of
R19499 T25545 T25539 punct .,is
R19500 T25546 T25547 det The,p-value
R19501 T25547 T25550 nsubj p-value,transfected
R19502 T25548 T25547 prep of,p-value
R19503 T25549 T25548 pobj cells,of
R19504 T25550 T25550 ROOT transfected,transfected
R19505 T25551 T25550 prep with,transfected
R19506 T25552 T25551 pobj KD,with
R19507 T25553 T25550 prep compared,transfected
R19508 T25554 T25553 prep to,compared
R19509 T25555 T25559 nsubj those,was
R19510 T25556 T25555 amod transfected,those
R19511 T25557 T25556 prep with,transfected
R19512 T25558 T25557 pobj WT,with
R19513 T25559 T25559 ROOT was,was
R19514 T25560 T25559 attr 0.05,was
R19515 T25561 T25559 punct .,was
R19516 T25562 T25563 punct (,C
R19517 T25563 T25563 ROOT C,C
R19518 T25564 T25563 punct ),C
R19519 T25565 T25567 nsubjpass MDMs,removed
R19520 T25566 T25567 auxpass were,removed
R19521 T25567 T25567 ROOT removed,removed
R19522 T25568 T25567 prep from,removed
R19523 T25569 T25570 det the,plate
R19524 T25570 T25568 pobj plate,from
R19525 T25571 T25567 advcl using,removed
R19526 T25572 T25571 dobj accutase,using
R19527 T25573 T25572 cc and,accutase
R19528 T25574 T25572 conj apoptosis,accutase
R19529 T25575 T25572 prep of,accutase
R19530 T25576 T25575 pobj MDMs,of
R19531 T25577 T25578 auxpass was,measured
R19532 T25578 T25567 conj measured,removed
R19533 T25579 T25578 agent by,measured
R19534 T25580 T25581 compound flow,cytometry
R19535 T25581 T25579 pobj cytometry,by
R19536 T25582 T25578 advcl using,measured
R19537 T25583 T25584 compound Annexin,V-FITC
R19538 T25584 T25582 dobj V-FITC,using
R19539 T25585 T25584 cc and,V-FITC
R19540 T25586 T25587 compound propidium,iodine
R19541 T25587 T25584 conj iodine,V-FITC
R19542 T25588 T25587 punct (,iodine
R19543 T25589 T25587 appos PI,iodine
R19544 T25590 T25587 punct ),iodine
R19545 T25591 T25567 punct .,removed
R19546 T25592 T25597 punct (,lysates
R19547 T25593 T25597 dep D,lysates
R19548 T25594 T25595 punct ),Whole
R19549 T25595 T25596 amod Whole,cell
R19550 T25596 T25597 nsubj cell,lysates
R19551 T25597 T25597 ROOT lysates,lysates
R19552 T25598 T25597 prep from,lysates
R19553 T25599 T25601 det the,RAW
R19554 T25600 T25601 amod transfected,RAW
R19555 T25601 T25598 pobj RAW,from
R19556 T25602 T25603 nummod 264.7,cells
R19557 T25603 T25605 nsubjpass cells,subjected
R19558 T25604 T25605 auxpass were,subjected
R19559 T25605 T25597 ccomp subjected,lysates
R19560 T25606 T25605 prep to,subjected
R19561 T25607 T25609 amod Western,analysis
R19562 T25608 T25609 compound blot,analysis
R19563 T25609 T25606 pobj analysis,to
R19564 T25610 T25609 prep with,analysis
R19565 T25611 T25610 pobj phospho-Ser276,with
R19566 T25612 T25611 cc or,phospho-Ser276
R19567 T25613 T25614 compound phospho-Ser536,NF-κB
R19568 T25614 T25611 conj NF-κB,phospho-Ser276
R19569 T25615 T25616 nummod p65,antibodies
R19570 T25616 T25609 appos antibodies,analysis
R19571 T25617 T25597 punct .,lysates
R19572 T25618 T25620 nsubjpass Blots,immunoblotted
R19573 T25619 T25620 auxpass were,immunoblotted
R19574 T25620 T25620 ROOT immunoblotted,immunoblotted
R19575 T25621 T25620 prep with,immunoblotted
R19576 T25622 T25621 pobj PKCα,with
R19577 T25623 T25624 aux to,determine
R19578 T25624 T25620 advcl determine,immunoblotted
R19579 T25625 T25627 amod equal,expression
R19580 T25626 T25627 compound protein,expression
R19581 T25627 T25624 dobj expression,determine
R19582 T25628 T25627 prep for,expression
R19583 T25629 T25631 det the,constructs
R19584 T25630 T25631 compound PKCα,constructs
R19585 T25631 T25628 pobj constructs,for
R19586 T25632 T25620 punct .,immunoblotted
R19587 T25633 T25634 nsubj β-actin,served
R19588 T25634 T25634 ROOT served,served
R19589 T25635 T25634 prep as,served
R19590 T25636 T25638 det a,control
R19591 T25637 T25638 compound loading,control
R19592 T25638 T25635 pobj control,as
R19593 T25639 T25634 punct .,served
R19594 T25640 T25640 ROOT Shown,Shown
R19595 T25641 T25640 auxpass is,Shown
R19596 T25642 T25644 det a,blot
R19597 T25643 T25644 amod representative,blot
R19598 T25644 T25640 nsubjpass blot,Shown
R19599 T25645 T25644 prep from,blot
R19600 T25646 T25648 nummod three,experiments
R19601 T25647 T25648 amod independent,experiments
R19602 T25648 T25645 pobj experiments,from
R19603 T25649 T25640 punct .,Shown
R19604 T25650 T25653 punct (,MDM
R19605 T25651 T25653 nmod E,MDM
R19606 T25652 T25653 punct ),MDM
R19607 T25653 T25660 nmod MDM,cells
R19608 T25654 T25653 cc or,MDM
R19609 T25655 T25656 punct (,F
R19610 T25656 T25653 conj F,MDM
R19611 T25657 T25656 punct ),F
R19612 T25658 T25653 conj RAW,MDM
R19613 T25659 T25660 nummod 264.7,cells
R19614 T25660 T25663 nsubjpass cells,transfected
R19615 T25661 T25663 auxpass were,transfected
R19616 T25662 T25663 advmod transiently,transfected
R19617 T25663 T25663 ROOT transfected,transfected
R19618 T25664 T25663 prep with,transfected
R19619 T25665 T25666 det a,pNF-κB-SEAP
R19620 T25666 T25664 pobj pNF-κB-SEAP,with
R19621 T25667 T25666 prep along,pNF-κB-SEAP
R19622 T25668 T25667 prep with,along
R19623 T25669 T25673 det either,siRNA
R19624 T25670 T25673 nummod 100,siRNA
R19625 T25671 T25673 compound nM,siRNA
R19626 T25672 T25673 compound PKCα,siRNA
R19627 T25673 T25668 pobj siRNA,with
R19628 T25674 T25673 cc or,siRNA
R19629 T25675 T25676 compound control,siRNA
R19630 T25676 T25673 conj siRNA,siRNA
R19631 T25677 T25663 prep for,transfected
R19632 T25678 T25679 nummod 20-24,hours
R19633 T25679 T25677 pobj hours,for
R19634 T25680 T25663 punct .,transfected
R19635 T25681 T25684 nsubjpass Cells,starved
R19636 T25682 T25684 auxpass were,starved
R19637 T25683 T25684 advmod serum,starved
R19638 T25684 T25684 ROOT starved,starved
R19639 T25685 T25684 prep for,starved
R19640 T25686 T25687 nummod 2-4,hours
R19641 T25687 T25685 pobj hours,for
R19642 T25688 T25684 cc and,starved
R19643 T25689 T25684 conj stimulated,starved
R19644 T25690 T25689 prep with,stimulated
R19645 T25691 T25693 nummod 100,M-CSF
R19646 T25692 T25693 amod ng/ml,M-CSF
R19647 T25693 T25690 pobj M-CSF,with
R19648 T25694 T25693 prep for,M-CSF
R19649 T25695 T25696 nummod 6,hours
R19650 T25696 T25694 pobj hours,for
R19651 T25697 T25693 prep for,M-CSF
R19652 T25698 T25697 pobj MDM,for
R19653 T25699 T25698 cc or,MDM
R19654 T25700 T25698 conj RAW,MDM
R19655 T25701 T25700 nummod 264.7,RAW
R19656 T25702 T25693 prep for,M-CSF
R19657 T25703 T25704 nummod 2,hours
R19658 T25704 T25702 pobj hours,for
R19659 T25705 T25693 cc and,M-CSF
R19660 T25706 T25708 advmod then,secretion
R19661 T25707 T25708 compound SEAP,secretion
R19662 T25708 T25693 conj secretion,M-CSF
R19663 T25709 T25708 prep in,secretion
R19664 T25710 T25711 det the,medium
R19665 T25711 T25709 pobj medium,in
R19666 T25712 T25713 auxpass was,measured
R19667 T25713 T25684 conj measured,starved
R19668 T25714 T25684 punct .,starved
R19669 T25715 T25715 ROOT Shown,Shown
R19670 T25716 T25715 auxpass is,Shown
R19671 T25717 T25715 nsubjpass data,Shown
R19672 T25718 T25717 prep of,data
R19673 T25719 T25721 nummod three,experiments
R19674 T25720 T25721 amod independent,experiments
R19675 T25721 T25718 pobj experiments,of
R19676 T25722 T25715 punct .,Shown
R19677 T25723 T25724 punct (,G
R19678 T25724 T25724 ROOT G,G
R19679 T25725 T25724 punct ),G
R19680 T25726 T25728 nsubjpass MDMs,removed
R19681 T25727 T25728 auxpass were,removed
R19682 T25728 T25728 ROOT removed,removed
R19683 T25729 T25728 prep from,removed
R19684 T25730 T25731 det the,plate
R19685 T25731 T25729 pobj plate,from
R19686 T25732 T25728 advcl using,removed
R19687 T25733 T25732 dobj accutase,using
R19688 T25734 T25733 cc and,accutase
R19689 T25735 T25733 conj apoptosis,accutase
R19690 T25736 T25733 prep of,accutase
R19691 T25737 T25736 pobj MDMs,of
R19692 T25738 T25739 auxpass was,measured
R19693 T25739 T25728 conj measured,removed
R19694 T25740 T25739 agent by,measured
R19695 T25741 T25742 compound Annexin,V-FITC
R19696 T25742 T25740 pobj V-FITC,by
R19697 T25743 T25742 cc and,V-FITC
R19698 T25744 T25745 compound propidium,iodine
R19699 T25745 T25742 conj iodine,V-FITC
R19700 T25746 T25747 punct (,PI
R19701 T25747 T25745 appos PI,iodine
R19702 T25748 T25745 punct ),iodine
R19703 T25749 T25739 xcomp staining,measured
R19704 T25750 T25739 cc and,measured
R19705 T25751 T25739 conj analyzed,measured
R19706 T25752 T25751 agent by,analyzed
R19707 T25753 T25754 compound flow,cytometry
R19708 T25754 T25752 pobj cytometry,by
R19709 T25755 T25728 punct .,removed
R19710 T25756 T25761 punct (,lysates
R19711 T25757 T25760 compound H,cell
R19712 T25758 T25759 punct ),Whole
R19713 T25759 T25760 compound Whole,cell
R19714 T25760 T25761 nsubj cell,lysates
R19715 T25761 T25761 ROOT lysates,lysates
R19716 T25762 T25761 prep from,lysates
R19717 T25763 T25765 det the,MDM
R19722 T25768 T25769 nummod 264.7,cells
R19723 T25769 T25762 pobj cells,from
R19724 T25770 T25771 auxpass were,subjected
R19725 T25771 T25761 conj subjected,lysates
R19726 T25772 T25771 prep to,subjected
R19727 T25773 T25775 amod Western,analysis
R19728 T25774 T25775 compound blot,analysis
R19729 T25775 T25772 pobj analysis,to
R19730 T25776 T25771 prep with,subjected
R19731 T25777 T25778 compound PKCα,antibody
R19732 T25778 T25776 pobj antibody,with
R19733 T25779 T25761 punct .,lysates
R19734 T25780 T25781 nsubj β-actin,served
R19735 T25781 T25781 ROOT served,served
R19736 T25782 T25781 prep as,served
R19737 T25783 T25785 det a,control
R19738 T25784 T25785 compound loading,control
R19739 T25785 T25782 pobj control,as
R19740 T25786 T25781 punct .,served
R19741 T25787 T25787 ROOT Shown,Shown
R19742 T25788 T25787 auxpass is,Shown
R19743 T25789 T25791 det a,blot
R19744 T25790 T25791 amod representative,blot
R19745 T25791 T25787 nsubjpass blot,Shown
R19746 T25792 T25791 prep from,blot
R19747 T25793 T25794 advmod at,least
R19748 T25794 T25795 advmod least,three
R19749 T25795 T25797 nummod three,experiments
R19750 T25796 T25797 amod independent,experiments
R19751 T25797 T25792 pobj experiments,from
R19752 T25798 T25787 punct .,Shown
R19477 T25523 T25523 ROOT starved,starved
R19478 T25524 T25523 cc and,starved
R19479 T25525 T25523 conj stimulated,starved
R19480 T25526 T25525 prep with,stimulated
R19481 T25527 T25526 pobj M-CSF,with
R19482 T25528 T25525 cc and,stimulated
R19718 T25764 T25765 amod transfected,MDM
R19719 T25765 T25769 nmod MDM,cells
R19720 T25766 T25765 cc and,MDM
R19721 T25767 T25765 conj RAW,MDM

test2

Id Subject Object Predicate Lexical cue Negation
T10126 139-143 Protein denotes PKCα
T10127 144-145 Protein denotes β
T10128 146-156 Negative_regulation denotes inhibitors
T10129 202-207 Protein denotes M-CSF
T10130 242-246 Protein denotes PKCα
T10131 286-291 Protein denotes M-CSF
T10132 326-330 Protein denotes PKCα
T10133 403-407 Protein denotes PKCα
T10134 411-427 Negative_regulation denotes kinase-deficient
T10135 429-431 Negative_regulation denotes KD
T10136 433-437 Protein denotes PKCα
T10137 553-567 Gene_expression denotes co-transfected
T10138 592-596 Protein denotes PKCα
T10139 661-666 Protein denotes M-CSF
T10140 667-677 Positive_regulation denotes activation
T10141 724-729 Protein denotes M-CSF
T10142 744-754 Gene_expression denotes expressing
T10143 813-815 Negative_regulation denotes KD
T10144 816-820 Protein denotes PKCα true
T10145 853-858 Protein denotes M-CSF
T10146 897-901 Protein denotes PKCα
T10147 902-913 Gene_expression denotes transfected
T10148 960-971 Gene_expression denotes transfected
T10149 980-984 Protein denotes PKCα true
T10150 1040-1045 Protein denotes M-CSF
T10151 1046-1056 Positive_regulation denotes activation true
T10152 1103-1114 Gene_expression denotes transfected
T10153 1123-1127 Protein denotes PKCα true
T10154 1141-1151 Gene_expression denotes Expression true
T10155 1159-1161 Negative_regulation denotes KD
T10156 1162-1166 Protein denotes PKCα
T10157 1206-1211 Protein denotes M-CSF
T10158 1277-1288 Gene_expression denotes transfected
T10159 1297-1301 Protein denotes PKCα
T10160 3143-3153 Gene_expression denotes expressing
T10161 3164-3168 Protein denotes PKCα
T10162 3172-3174 Negative_regulation denotes KD
T10163 3175-3179 Protein denotes PKCα
T10164 3194-3203 Protein denotes Annexin V
T10165 3239-3244 Protein denotes M-CSF
T10166 3298-3307 Protein denotes Annexin V
T10167 3311-3319 Negative_regulation denotes negative
T10168 3338-3348 Gene_expression denotes expression
T10169 3355-3359 Protein denotes PKCα
T10170 3405-3415 Gene_expression denotes expression
T10171 3419-3421 Negative_regulation denotes KD
T10172 3422-3426 Protein denotes PKCα
T10173 3437-3442 Protein denotes M-CSF
T10174 3509-3515 Regulation denotes effect
T10175 3519-3529 Gene_expression denotes expressing
T10176 3534-3538 Protein denotes PKCα
T10177 3599-3609 Gene_expression denotes expression
T10178 3613-3615 Negative_regulation denotes KD
T10179 3616-3620 Protein denotes PKCα
T10180 3648-3654 Regulation denotes affect
T10181 3672-3687 Phosphorylation denotes phosphorylation
T10182 3691-3697 Entity denotes Ser536
T10183 3707-3710 Protein denotes p65
T10184 3716-3726 Negative_regulation denotes attenuated
T10185 3731-3746 Phosphorylation denotes phosphorylation
T10186 3750-3756 Entity denotes Ser276
T10187 3758-3768 Gene_expression denotes Expression
T10188 3775-3779 Protein denotes PKCα
T10189 3788-3794 Regulation denotes effect
T10190 3799-3814 Phosphorylation denotes phosphorylation
T10191 3849-3854 Protein denotes M-CSF
T10192 3904-3908 Protein denotes PKCα
T10193 3925-3930 Protein denotes M-CSF
T10194 3987-3996 Regulation denotes regulated
T10195 4005-4020 Phosphorylation denotes phosphorylation
T10196 4024-4030 Entity denotes Ser276
T10197 4040-4043 Protein denotes p65
T10198 4081-4085 Protein denotes PKCα
T10199 4096-4101 Protein denotes M-CSF
T10200 4159-4169 Protein denotes PKCα siRNA
T10201 4220-4230 Protein denotes PKCα siRNA
T10202 4306-4311 Protein denotes M-CSF
T10203 4313-4321 Negative_regulation denotes Reducing
T10204 4329-4333 Protein denotes PKCα
T10205 4334-4344 Gene_expression denotes expression
T10206 4355-4360 Protein denotes M-CSF
T10207 4526-4535 Protein denotes Annexin V
T10208 4563-4573 Protein denotes PKCα siRNA
T10209 4611-4616 Protein denotes M-CSF
T10210 4680-4690 Protein denotes PKCα siRNA
T10211 4787-4797 Protein denotes PKCα siRNA
T10212 4811-4820 Negative_regulation denotes decreased
T10213 4821-4825 Protein denotes PKCα
T10214 4834-4844 Gene_expression denotes expression
T10215 4905-4909 Protein denotes PKCα
T10216 4941-4946 Protein denotes M-CSF
T25444 1347-1351 Protein denotes PKCα
T25445 1352-1361 Regulation denotes regulates
T25446 1362-1377 Phosphorylation denotes phosphorylation
T25447 1387-1390 Protein denotes p65
T25448 1394-1400 Entity denotes Ser276
T25449 1500-1504 Protein denotes PKCα
T25450 1512-1528 Negative_regulation denotes kinase-deficient
T25451 1530-1532 Negative_regulation denotes KD
T25452 1534-1538 Protein denotes PKCα
T25453 1610-1615 Protein denotes M-CSF
T25454 1915-1924 Protein denotes Annexin V
T25455 2147-2151 Protein denotes PKCα
T25456 2179-2189 Gene_expression denotes expression
T25457 2198-2202 Protein denotes PKCα
T25458 2215-2222 Protein denotes β-actin
T25459 2423-2433 Protein denotes PKCα siRNA
T25460 2537-2542 Protein denotes M-CSF
T25461 2778-2787 Protein denotes Annexin V
T25462 2988-2995 Protein denotes β-actin
R7588 T10126 T10128 themeOf PKCα,inhibitors
R7589 T10127 T10128 themeOf β,inhibitors
R7590 T10133 T10134 themeOf PKCα,kinase-deficient
R7591 T10136 T10134 themeOf PKCα,kinase-deficient
R7592 T10138 T10137 themeOf PKCα,co-transfected
R7593 T10139 T10140 themeOf M-CSF,activation
R7594 T10144 T10143 themeOf PKCα,KD
R7595 T10146 T10147 themeOf PKCα,transfected
R7596 T10149 T10148 themeOf PKCα,transfected
R7597 T10150 T10151 themeOf M-CSF,activation
R7598 T10153 T10152 themeOf PKCα,transfected
R7599 T10156 T10155 themeOf PKCα,KD
R7600 T10159 T10158 themeOf PKCα,transfected
R7601 T10161 T10160 themeOf PKCα,expressing
R7602 T10163 T10162 themeOf PKCα,KD
R7603 T10166 T10167 themeOf Annexin V,negative
R7604 T10169 T10168 themeOf PKCα,expression
R7605 T10172 T10171 themeOf PKCα,KD
R7606 T10175 T10174 causeOf expressing,effect
R7607 T10176 T10175 themeOf PKCα,expressing
R7608 T10177 T10180 causeOf expression,affect
R7609 T10179 T10177 themeOf PKCα,expression
R7610 T10179 T10178 themeOf PKCα,KD
R7611 T10181 T10180 themeOf phosphorylation,affect
R7612 T10182 T10181 themeOf Ser536,phosphorylation
R7613 T10182 T10183 partOf Ser536,p65
R7614 T10185 T10184 themeOf phosphorylation,attenuated
R7615 T10186 T10185 themeOf Ser276,phosphorylation
R7616 T10187 T10189 causeOf Expression,effect
R7617 T10188 T10187 themeOf PKCα,Expression
R7618 T10190 T10189 themeOf phosphorylation,effect
R7619 T10196 T10195 themeOf Ser276,phosphorylation
R7620 T10196 T10197 partOf Ser276,p65
R7621 T10204 T10205 themeOf PKCα,expression
R7622 T10205 T10203 themeOf expression,Reducing
R7623 T10211 T10212 causeOf PKCα siRNA,decreased
R7624 T10213 T10214 themeOf PKCα,expression
R7625 T10214 T10212 themeOf expression,decreased
R19422 T25444 T25445 causeOf PKCα,regulates
R19423 T25446 T25445 themeOf phosphorylation,regulates
R19424 T25448 T25446 themeOf Ser276,phosphorylation
R19425 T25448 T25447 partOf Ser276,p65
R19426 T25449 T25450 themeOf PKCα,kinase-deficient
R19427 T25452 T25450 themeOf PKCα,kinase-deficient
R19428 T25457 T25456 themeOf PKCα,expression