PMC:3245220 / 21378-23104
Annnotations
bionlp-st-ge-2016-uniprot
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T9812 | 0-5 | P09603 | denotes | M-CSF |
T9813 | 2-5 | P04141 | denotes | CSF |
T9814 | 146-150 | P25963 | denotes | IκBα |
T9815 | 245-250 | P09603 | denotes | M-CSF |
T9816 | 247-250 | P04141 | denotes | CSF |
T9817 | 484-489 | P09603 | denotes | M-CSF |
T9818 | 486-489 | P04141 | denotes | CSF |
T9819 | 491-495 | P25963 | denotes | IκBα |
T9820 | 557-562 | P09603 | denotes | M-CSF |
T9821 | 559-562 | P04141 | denotes | CSF |
T9822 | 572-576 | P25963 | denotes | IκBα |
T9823 | 636-640 | P25963 | denotes | IκBα |
T9824 | 1471-1476 | P09603 | denotes | M-CSF |
T9825 | 1473-1476 | P04141 | denotes | CSF |
T9826 | 1616-1621 | P09603 | denotes | M-CSF |
T9827 | 1618-1621 | P04141 | denotes | CSF |
T9828 | 1682-1687 | P09603 | denotes | M-CSF |
T9829 | 1684-1687 | P04141 | denotes | CSF |
T25317 | 838-843 | P09603 | denotes | M-CSF |
T25318 | 840-843 | P04141 | denotes | CSF |
T25319 | 1039-1044 | P09603 | denotes | M-CSF |
T25320 | 1041-1044 | P04141 | denotes | CSF |
T25321 | 1177-1181 | P25963 | denotes | IκBα |
T25322 | 1193-1198 | P04406 | denotes | GAPDH |
T25323 | 1222-1230 | Q04864 | denotes | relative |
T25324 | 1248-1252 | P25963 | denotes | IκBα |
bionlp-st-ge-2016-reference
Id | Subject | Object | Predicate | Lexical cue | Speculation |
---|---|---|---|---|---|
T9830 | 161-168 | Positive_regulation | denotes | induced | |
T9831 | 1640-1650 | Gene_expression | denotes | expression | |
T9832 | 563-571 | Positive_regulation | denotes | enhanced | |
T9833 | 582-592 | Gene_expression | denotes | expression | |
T9834 | 626-635 | Negative_regulation | denotes | decreased | |
T9835 | 646-656 | Gene_expression | denotes | expression | |
T9836 | 1494-1504 | Gene_expression | denotes | expression | true |
T9837 | 1554-1563 | Regulation | denotes | regulated | |
T9838 | 1608-1615 | Negative_regulation | denotes | reduced | |
T9839 | 1622-1632 | Positive_regulation | denotes | stimulated | |
T9840 | 146-150 | Protein | denotes | IκBα | |
T9841 | 491-495 | Protein | denotes | IκBα | |
T9842 | 572-576 | Protein | denotes | IκBα | |
T9843 | 636-640 | Protein | denotes | IκBα | |
T9844 | 1532-1538 | Protein | denotes | BCL-xL | |
T9845 | 1633-1639 | Protein | denotes | BCL-xL | |
T9846 | 0-5 | Protein | denotes | M-CSF | |
T9847 | 245-250 | Protein | denotes | M-CSF | |
T9848 | 484-489 | Protein | denotes | M-CSF | |
T9849 | 557-562 | Protein | denotes | M-CSF | |
T9850 | 1471-1476 | Protein | denotes | M-CSF | |
T9851 | 1616-1621 | Protein | denotes | M-CSF | |
T9852 | 1682-1687 | Protein | denotes | M-CSF | |
T25325 | 1236-1244 | Positive_regulation | denotes | increase | |
T25326 | 1268-1278 | Gene_expression | denotes | expression | |
T25327 | 1236-1244 | Positive_regulation | denotes | increase | |
T25328 | 1268-1278 | Gene_expression | denotes | expression | |
T25329 | 1177-1181 | Protein | denotes | IκBα | |
T25330 | 1183-1189 | Protein | denotes | BCL-xl | |
T25331 | 1248-1252 | Protein | denotes | IκBα | |
T25332 | 1256-1262 | Protein | denotes | BCL-xl | |
T25333 | 838-843 | Protein | denotes | M-CSF | |
T25334 | 1039-1044 | Protein | denotes | M-CSF | |
T25335 | 824-834 | Negative_regulation | denotes | Inhibition | |
R7456 | T9831 | T9839 | themeOf | expression,stimulated | |
R7457 | T9833 | T9832 | themeOf | expression,enhanced | |
R7458 | T9835 | T9834 | themeOf | expression,decreased | |
R7459 | T9839 | T9838 | themeOf | stimulated,reduced | |
R7460 | T9840 | T9830 | themeOf | IκBα,induced | |
R7461 | T9842 | T9833 | themeOf | IκBα,expression | |
R7462 | T9843 | T9835 | themeOf | IκBα,expression | |
R7463 | T9844 | T9837 | themeOf | BCL-xL,regulated | |
R7464 | T9844 | T9836 | themeOf | BCL-xL,expression | |
R7465 | T9845 | T9831 | themeOf | BCL-xL,expression | |
R7466 | T9849 | T9832 | causeOf | M-CSF,enhanced | |
R19373 | T25326 | T25325 | themeOf | expression,increase | |
R19374 | T25328 | T25327 | themeOf | expression,increase | |
R19375 | T25331 | T25326 | themeOf | IκBα,expression | |
R19376 | T25332 | T25328 | themeOf | BCL-xl,expression | |
R19377 | T25333 | T25335 | themeOf | M-CSF,Inhibition |
bionlp-st-ge-2016-reference-tees
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T10007 | 0-5 | Protein | denotes | M-CSF |
T10008 | 16-19 | Protein | denotes | PKC |
T10009 | 30-35 | Protein | denotes | NF-κB |
T10010 | 6-15 | Positive_regulation | denotes | dependent |
T10011 | 36-44 | Gene_expression | denotes | targeted |
T10012 | 51-56 | Protein | denotes | NF-κB |
T10013 | 109-119 | Protein | denotes | IκB family |
T10014 | 131-144 | Protein | denotes | IκB molecules |
T10015 | 146-150 | Protein | denotes | IκBα |
T10016 | 172-177 | Protein | denotes | NF-κB |
T10017 | 178-188 | Positive_regulation | denotes | activation |
T10018 | 161-168 | Positive_regulation | denotes | induced |
T10019 | 213-216 | Protein | denotes | PKC |
T10020 | 227-232 | Protein | denotes | NF-κB |
T10021 | 245-250 | Protein | denotes | M-CSF |
T10022 | 309-312 | Protein | denotes | PKC |
T10023 | 346-351 | Protein | denotes | NF-κB |
T10024 | 217-226 | Regulation | denotes | regulated |
T10025 | 295-305 | Negative_regulation | denotes | inhibition |
T10026 | 419-422 | Protein | denotes | PKC |
T10027 | 484-489 | Protein | denotes | M-CSF |
T10028 | 491-500 | Protein | denotes | IκBα gene |
T10029 | 557-562 | Protein | denotes | M-CSF |
T10030 | 572-581 | Protein | denotes | IκBα gene |
T10031 | 597-600 | Protein | denotes | PKC |
T10032 | 636-645 | Protein | denotes | IκBα gene |
T10033 | 719-722 | Protein | denotes | PKC |
T10034 | 732-737 | Protein | denotes | NF-κB |
T10035 | 582-592 | Gene_expression | denotes | expression |
T10036 | 601-611 | Negative_regulation | denotes | inhibition |
T10037 | 646-656 | Gene_expression | denotes | expression |
T10038 | 563-571 | Positive_regulation | denotes | enhanced |
T10039 | 626-635 | Negative_regulation | denotes | decreased |
T10040 | 1420-1423 | Protein | denotes | PKC |
T10041 | 1471-1476 | Protein | denotes | M-CSF |
T10042 | 1567-1572 | Protein | denotes | NF-κB |
T10043 | 1616-1621 | Protein | denotes | M-CSF |
T10044 | 1682-1687 | Protein | denotes | M-CSF |
T25409 | 838-843 | Protein | denotes | M-CSF |
T25410 | 852-855 | Protein | denotes | PKC |
T25411 | 864-869 | Protein | denotes | NF-κB |
T25412 | 844-851 | Positive_regulation | denotes | induced |
T25413 | 824-834 | Negative_regulation | denotes | Inhibition |
T25414 | 1039-1044 | Protein | denotes | M-CSF |
T25415 | 1177-1189 | Protein | denotes | IκBα, BCL-xl |
T25416 | 1193-1198 | Protein | denotes | GAPDH |
T25417 | 1248-1252 | Protein | denotes | IκBα |
T25418 | 1256-1259 | Protein | denotes | BCL |
T25419 | 1268-1278 | Gene_expression | denotes | expression |
T25420 | 1268-1278 | Gene_expression | denotes | expression |
T25421 | 1236-1244 | Positive_regulation | denotes | increase |
T25422 | 1236-1244 | Positive_regulation | denotes | increase |
R7530 | T10007 | T10010 | causeOf | M-CSF,dependent |
R7531 | T10008 | T10010 | themeOf | PKC,dependent |
R7532 | T10009 | T10011 | themeOf | NF-κB,targeted |
R7533 | T10015 | T10018 | themeOf | IκBα,induced |
R7534 | T10016 | T10017 | themeOf | NF-κB,activation |
R7535 | T10017 | T10018 | causeOf | activation,induced |
R7536 | T10019 | T10024 | causeOf | PKC,regulated |
R7537 | T10020 | T10024 | themeOf | NF-κB,regulated |
R7538 | T10022 | T10025 | themeOf | PKC,inhibition |
R7539 | T10029 | T10038 | causeOf | M-CSF,enhanced |
R7540 | T10030 | T10035 | themeOf | IκBα gene,expression |
R7541 | T10031 | T10036 | themeOf | PKC,inhibition |
R7542 | T10032 | T10037 | themeOf | IκBα gene,expression |
R7543 | T10035 | T10038 | themeOf | expression,enhanced |
R7544 | T10036 | T10039 | causeOf | inhibition,decreased |
R7545 | T10037 | T10039 | themeOf | expression,decreased |
R19406 | T25409 | T25412 | causeOf | M-CSF,induced |
R19407 | T25410 | T25412 | themeOf | PKC,induced |
R19408 | T25412 | T25413 | themeOf | induced,Inhibition |
R19409 | T25417 | T25419 | themeOf | IκBα,expression |
R19410 | T25418 | T25420 | themeOf | BCL,expression |
R19411 | T25419 | T25421 | themeOf | expression,increase |
R19412 | T25420 | T25422 | themeOf | expression,increase |
events-check-again
Id | Subject | Object | Predicate | Lexical cue | Speculation |
---|---|---|---|---|---|
T9984 | 0-5 | Protein | denotes | M-CSF | |
T9985 | 146-150 | Protein | denotes | IκBα | |
T9986 | 161-168 | Positive_regulation | denotes | induced | |
T9987 | 245-250 | Protein | denotes | M-CSF | |
T9988 | 484-489 | Protein | denotes | M-CSF | |
T9989 | 491-495 | Protein | denotes | IκBα | |
T9990 | 557-562 | Protein | denotes | M-CSF | |
T9991 | 563-571 | Positive_regulation | denotes | enhanced | |
T9992 | 572-576 | Protein | denotes | IκBα | |
T9993 | 582-592 | Gene_expression | denotes | expression | |
T9994 | 626-635 | Negative_regulation | denotes | decreased | |
T9995 | 636-640 | Protein | denotes | IκBα | |
T9996 | 646-656 | Gene_expression | denotes | expression | |
T9997 | 1471-1476 | Protein | denotes | M-CSF | |
T9998 | 1494-1504 | Gene_expression | denotes | expression | true |
T9999 | 1532-1538 | Protein | denotes | BCL-xL | |
T10000 | 1554-1563 | Regulation | denotes | regulated | |
T10001 | 1608-1615 | Negative_regulation | denotes | reduced | |
T10002 | 1616-1621 | Protein | denotes | M-CSF | |
T10003 | 1622-1632 | Positive_regulation | denotes | stimulated | |
T10004 | 1633-1639 | Protein | denotes | BCL-xL | |
T10005 | 1640-1650 | Gene_expression | denotes | expression | |
T10006 | 1682-1687 | Protein | denotes | M-CSF | |
T25398 | 824-834 | Negative_regulation | denotes | Inhibition | |
T25399 | 838-843 | Protein | denotes | M-CSF | |
T25400 | 1039-1044 | Protein | denotes | M-CSF | |
T25401 | 1177-1181 | Protein | denotes | IκBα | |
T25402 | 1183-1189 | Protein | denotes | BCL-xl | |
T25403 | 1236-1244 | Positive_regulation | denotes | increase | |
T25404 | 1236-1244 | Positive_regulation | denotes | increase | |
T25405 | 1248-1252 | Protein | denotes | IκBα | |
T25406 | 1256-1262 | Protein | denotes | BCL-xl | |
T25407 | 1268-1278 | Gene_expression | denotes | expression | |
T25408 | 1268-1278 | Gene_expression | denotes | expression | |
R7519 | T9985 | T9986 | themeOf | IκBα,induced | |
R7520 | T9990 | T9991 | causeOf | M-CSF,enhanced | |
R7521 | T9992 | T9993 | themeOf | IκBα,expression | |
R7522 | T9993 | T9991 | themeOf | expression,enhanced | |
R7523 | T9995 | T9996 | themeOf | IκBα,expression | |
R7524 | T9996 | T9994 | themeOf | expression,decreased | |
R7525 | T9999 | T10000 | themeOf | BCL-xL,regulated | |
R7526 | T9999 | T9998 | themeOf | BCL-xL,expression | |
R7527 | T10003 | T10001 | themeOf | stimulated,reduced | |
R7528 | T10004 | T10005 | themeOf | BCL-xL,expression | |
R7529 | T10005 | T10003 | themeOf | expression,stimulated | |
R19401 | T25399 | T25398 | themeOf | M-CSF,Inhibition | |
R19402 | T25405 | T25407 | themeOf | IκBα,expression | |
R19403 | T25406 | T25408 | themeOf | BCL-xl,expression | |
R19404 | T25407 | T25403 | themeOf | expression,increase | |
R19405 | T25408 | T25404 | themeOf | expression,increase |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T9869 | 404-409 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T9870 | 684-689 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T9871 | 1663-1668 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T25344 | 913-918 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T25345 | 953-958 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T25346 | 1314-1319 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
GO-MF
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T9862 | 16-19 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
T9863 | 213-216 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
T9864 | 309-312 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
T9865 | 419-422 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
T9866 | 597-600 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
T9867 | 719-722 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
T9868 | 309-321 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC activity |
T25342 | 852-855 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
T25343 | 1138-1140 | http://purl.obolibrary.org/obo/GO_0003964 | denotes | RT |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T10045 | 641-656 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
T10046 | 748-763 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
T10047 | 1459-1476 | http://purl.obolibrary.org/obo/GO_1903969 | denotes | response to M-CSF |
T10048 | 1459-1476 | http://purl.obolibrary.org/obo/GO_0036005 | denotes | response to M-CSF |
T10049 | 1459-1476 | http://purl.obolibrary.org/obo/GO_1903970 | denotes | response to M-CSF |
T10050 | 1459-1476 | http://purl.obolibrary.org/obo/GO_1903971 | denotes | response to M-CSF |
T10051 | 309-321 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC activity |
T10052 | 172-188 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T10053 | 577-592 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
T25423 | 1138-1140 | http://purl.obolibrary.org/obo/GO_0003964 | denotes | RT |
T25424 | 1263-1278 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
bionlp-st-ge-2016-coref
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T9809 | 1508-1531 | Anaphor | denotes | the anti-apoptotic gene |
T9810 | 1532-1538 | Antecedent | denotes | BCL-xL |
T9811 | 1540-1545 | Anaphor | denotes | which |
R7454 | T9809 | T9810 | boundBy | the anti-apoptotic gene,BCL-xL |
R7455 | T9811 | T9810 | boundBy | which,BCL-xL |
pmc-enju-pas
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T9622 | 0-15 | JJ | denotes | M-CSF-dependent |
T9623 | 16-19 | NN | denotes | PKC |
T9624 | 20-29 | VB | denotes | Regulates |
T9625 | 30-44 | JJ | denotes | NF-κB-targeted |
T9626 | 45-50 | NN | denotes | Genes |
T9627 | 51-56 | NN | denotes | NF-κB |
T9628 | 57-64 | VB | denotes | induces |
T9629 | 65-66 | DT | denotes | a |
T9630 | 67-73 | NN | denotes | number |
T9631 | 74-76 | IN | denotes | of |
T9632 | 77-87 | JJ | denotes | downstream |
T9633 | 88-93 | NN | denotes | genes |
T9634 | 93-94 | -COMMA- | denotes | , |
T9635 | 95-104 | VB | denotes | including |
T9636 | 105-108 | DT | denotes | the |
T9637 | 109-112 | NN | denotes | IκB |
T9638 | 113-119 | NN | denotes | family |
T9639 | 121-126 | IN | denotes | Among |
T9640 | 127-130 | DT | denotes | the |
T9641 | 131-134 | NN | denotes | IκB |
T9642 | 135-144 | NN | denotes | molecules |
T9643 | 144-145 | -COMMA- | denotes | , |
T9644 | 146-150 | NN | denotes | IκBα |
T9645 | 151-153 | VB | denotes | is |
T9646 | 154-160 | RB | denotes | highly |
T9647 | 161-168 | VB | denotes | induced |
T9648 | 169-171 | IN | denotes | by |
T9649 | 172-177 | NN | denotes | NF-κB |
T9650 | 178-188 | NN | denotes | activation |
T9651 | 189-190 | -LRB- | denotes | [ |
T9652 | 190-192 | CD | denotes | 40 |
T9653 | 192-193 | -RRB- | denotes | ] |
T9654 | 195-201 | VB | denotes | Having |
T9655 | 202-207 | VB | denotes | shown |
T9656 | 208-212 | IN | denotes | that |
T9657 | 213-216 | NN | denotes | PKC |
T9658 | 217-226 | VB | denotes | regulated |
T9659 | 227-232 | NN | denotes | NF-κB |
T9660 | 233-241 | NN | denotes | activity |
T9661 | 242-244 | IN | denotes | in |
T9662 | 245-261 | JJ | denotes | M-CSF-stimulated |
T9663 | 262-266 | NN | denotes | MDMs |
T9664 | 266-267 | -COMMA- | denotes | , |
T9665 | 268-270 | PRP | denotes | we |
T9666 | 271-275 | RB | denotes | next |
T9667 | 276-286 | VB | denotes | determined |
T9668 | 287-294 | IN | denotes | whether |
T9669 | 295-305 | NN | denotes | inhibition |
T9670 | 306-308 | IN | denotes | of |
T9671 | 309-312 | NN | denotes | PKC |
T9672 | 313-321 | NN | denotes | activity |
T9673 | 322-331 | VB | denotes | decreased |
T9674 | 332-342 | NN | denotes | expression |
T9675 | 343-345 | IN | denotes | of |
T9676 | 346-361 | JJ | denotes | NF-κB-regulated |
T9677 | 362-367 | NN | denotes | genes |
T9678 | 369-371 | PRP | denotes | We |
T9679 | 372-379 | VB | denotes | treated |
T9680 | 380-384 | CC | denotes | both |
T9681 | 385-389 | NN | denotes | MDMs |
T9682 | 390-393 | CC | denotes | and |
T9683 | 394-397 | NN | denotes | RAW |
T9684 | 398-403 | CD | denotes | 264.7 |
T9685 | 404-409 | NN | denotes | cells |
T9686 | 410-414 | IN | denotes | with |
T9687 | 415-418 | DT | denotes | the |
T9688 | 419-422 | NN | denotes | PKC |
T9689 | 423-432 | NN | denotes | inhibitor |
T9690 | 433-443 | NN | denotes | Ro-31-8220 |
T9691 | 444-447 | IN | denotes | for |
T9692 | 448-450 | CD | denotes | 30 |
T9693 | 451-458 | NN | denotes | minutes |
T9694 | 459-462 | CC | denotes | and |
T9695 | 463-467 | RB | denotes | then |
T9696 | 468-478 | VB | denotes | stimulated |
T9697 | 479-483 | IN | denotes | with |
T9698 | 484-489 | NN | denotes | M-CSF |
T9699 | 491-495 | NN | denotes | IκBα |
T9700 | 496-500 | NN | denotes | gene |
T9701 | 501-504 | VB | denotes | was |
T9702 | 505-513 | VB | denotes | measured |
T9703 | 514-516 | IN | denotes | by |
T9704 | 517-524 | NN | denotes | qRT-PCR |
T9705 | 526-528 | IN | denotes | As |
T9706 | 529-534 | VB | denotes | shown |
T9707 | 535-537 | IN | denotes | in |
T9708 | 538-545 | NN | denotes | Figures |
T9709 | 546-548 | NN | denotes | 6A |
T9710 | 549-552 | CC | denotes | and |
T9711 | 553-555 | NN | denotes | 6B |
T9712 | 555-556 | -COMMA- | denotes | , |
T9713 | 557-562 | NN | denotes | M-CSF |
T9714 | 563-571 | VB | denotes | enhanced |
T9715 | 572-576 | NN | denotes | IκBα |
T9716 | 577-581 | NN | denotes | gene |
T9717 | 582-592 | NN | denotes | expression |
T9718 | 593-596 | CC | denotes | and |
T9719 | 597-600 | NN | denotes | PKC |
T9720 | 601-611 | NN | denotes | inhibition |
T9721 | 612-614 | IN | denotes | by |
T9722 | 615-625 | NN | denotes | Ro-31-8220 |
T9723 | 626-635 | VB | denotes | decreased |
T9724 | 636-640 | NN | denotes | IκBα |
T9725 | 641-645 | NN | denotes | gene |
T9726 | 646-656 | NN | denotes | expression |
T9727 | 657-659 | IN | denotes | in |
T9728 | 660-664 | CC | denotes | both |
T9729 | 665-669 | NN | denotes | MDMs |
T9730 | 670-673 | CC | denotes | and |
T9731 | 674-677 | NN | denotes | RAW |
T9732 | 678-683 | CD | denotes | 264.7 |
T9733 | 684-689 | NN | denotes | cells |
T9734 | 690-691 | -LRB- | denotes | ( |
T9735 | 691-692 | NN | denotes | p |
T9736 | 692-693 | SYM | denotes | < |
T9737 | 693-697 | CD | denotes | 0.01 |
T9738 | 697-698 | -RRB- | denotes | ) |
T9739 | 698-699 | -COMMA- | denotes | , |
T9740 | 700-713 | VB | denotes | demonstrating |
T9741 | 714-718 | IN | denotes | that |
T9742 | 719-722 | NN | denotes | PKC |
T9743 | 723-731 | VB | denotes | affected |
T9744 | 732-747 | JJ | denotes | NF-κB-regulated |
T9745 | 748-752 | NN | denotes | gene |
T9746 | 753-763 | NN | denotes | expression |
T9747 | 764-766 | IN | denotes | in |
T9748 | 767-778 | NN | denotes | macrophages |
T9749 | 1390-1392 | TO | denotes | To |
T9750 | 1393-1400 | RB | denotes | further |
T9751 | 1401-1407 | VB | denotes | define |
T9752 | 1408-1411 | DT | denotes | the |
T9753 | 1412-1416 | NN | denotes | role |
T9754 | 1417-1419 | IN | denotes | of |
T9755 | 1420-1423 | NN | denotes | PKC |
T9756 | 1424-1426 | IN | denotes | in |
T9757 | 1427-1436 | VB | denotes | mediating |
T9758 | 1437-1442 | JJ | denotes | human |
T9759 | 1443-1446 | NN | denotes | MDM |
T9760 | 1447-1455 | NN | denotes | survival |
T9761 | 1456-1458 | IN | denotes | in |
T9762 | 1459-1467 | NN | denotes | response |
T9763 | 1468-1470 | TO | denotes | to |
T9764 | 1471-1476 | NN | denotes | M-CSF |
T9765 | 1476-1477 | -COMMA- | denotes | , |
T9766 | 1478-1480 | PRP | denotes | we |
T9767 | 1481-1489 | VB | denotes | examined |
T9768 | 1490-1493 | DT | denotes | the |
T9769 | 1494-1504 | NN | denotes | expression |
T9770 | 1505-1507 | IN | denotes | of |
T9771 | 1508-1511 | DT | denotes | the |
T9772 | 1512-1526 | JJ | denotes | anti-apoptotic |
T9773 | 1527-1531 | NN | denotes | gene |
T9774 | 1532-1538 | NN | denotes | BCL-xL |
T9775 | 1538-1539 | -COMMA- | denotes | , |
T9776 | 1540-1545 | WDT | denotes | which |
T9777 | 1546-1548 | VB | denotes | is |
T9778 | 1549-1553 | RB | denotes | also |
T9779 | 1554-1563 | VB | denotes | regulated |
T9780 | 1564-1566 | IN | denotes | by |
T9781 | 1567-1572 | NN | denotes | NF-κB |
T9782 | 1574-1576 | IN | denotes | As |
T9783 | 1577-1582 | VB | denotes | shown |
T9784 | 1583-1585 | IN | denotes | in |
T9785 | 1586-1592 | NN | denotes | Figure |
T9786 | 1593-1595 | NN | denotes | 6C |
T9787 | 1595-1596 | -COMMA- | denotes | , |
T9788 | 1597-1607 | NN | denotes | Ro-31-8220 |
T9789 | 1608-1615 | VB | denotes | reduced |
T9790 | 1616-1632 | JJ | denotes | M-CSF-stimulated |
T9791 | 1633-1639 | NN | denotes | BCL-xL |
T9792 | 1640-1650 | NN | denotes | expression |
T9793 | 1651-1659 | VB | denotes | compared |
T9794 | 1660-1662 | TO | denotes | to |
T9795 | 1663-1668 | NN | denotes | cells |
T9796 | 1669-1676 | VB | denotes | treated |
T9797 | 1677-1681 | IN | denotes | with |
T9798 | 1682-1687 | NN | denotes | M-CSF |
T9799 | 1688-1691 | CC | denotes | and |
T9800 | 1692-1695 | DT | denotes | the |
T9801 | 1696-1703 | NN | denotes | vehicle |
T9802 | 1704-1711 | NN | denotes | control |
T9803 | 1712-1716 | NN | denotes | DMSO |
T9804 | 1717-1718 | -LRB- | denotes | ( |
T9805 | 1718-1719 | NN | denotes | p |
T9806 | 1719-1720 | SYM | denotes | < |
T9807 | 1720-1724 | CD | denotes | 0.05 |
T9808 | 1724-1725 | -RRB- | denotes | ) |
T25222 | 824-834 | NN | denotes | Inhibition |
T25223 | 835-837 | IN | denotes | of |
T25224 | 838-851 | JJ | denotes | M-CSF-induced |
T25225 | 852-855 | NN | denotes | PKC |
T25226 | 856-863 | VB | denotes | reduces |
T25227 | 864-879 | JJ | denotes | NF-κB-regulated |
T25228 | 880-885 | NN | denotes | genes |
T25229 | 886-888 | IN | denotes | in |
T25230 | 889-893 | CC | denotes | both |
T25231 | 894-898 | NN | denotes | MDMs |
T25232 | 899-902 | CC | denotes | and |
T25233 | 903-906 | NN | denotes | RAW |
T25234 | 907-912 | CD | denotes | 264.7 |
T25235 | 913-918 | NN | denotes | cells |
T25236 | 920-924 | NN | denotes | MDMs |
T25237 | 925-926 | -LRB- | denotes | ( |
T25238 | 926-927 | NN | denotes | A |
T25239 | 928-931 | CC | denotes | and |
T25240 | 932-933 | NN | denotes | C |
T25241 | 933-934 | -RRB- | denotes | ) |
T25242 | 935-938 | CC | denotes | and |
T25243 | 939-942 | NN | denotes | RAW |
T25244 | 943-948 | CD | denotes | 264.7 |
T25245 | 949-950 | -LRB- | denotes | ( |
T25246 | 950-951 | NN | denotes | B |
T25247 | 951-952 | -RRB- | denotes | ) |
T25248 | 953-958 | NN | denotes | cells |
T25249 | 959-963 | VB | denotes | were |
T25250 | 964-974 | VB | denotes | pretreated |
T25251 | 975-979 | IN | denotes | with |
T25252 | 980-990 | NN | denotes | Ro-31-8220 |
T25253 | 991-993 | CC | denotes | or |
T25254 | 994-1001 | NN | denotes | solvent |
T25255 | 1002-1009 | NN | denotes | control |
T25256 | 1010-1014 | NN | denotes | DMSO |
T25257 | 1015-1018 | IN | denotes | for |
T25258 | 1019-1021 | CD | denotes | 30 |
T25259 | 1022-1029 | NN | denotes | minutes |
T25260 | 1030-1035 | RB | denotes | prior |
T25261 | 1036-1038 | TO | denotes | to |
T25262 | 1039-1044 | NN | denotes | M-CSF |
T25263 | 1045-1056 | NN | denotes | stimulation |
T25264 | 1057-1060 | IN | denotes | for |
T25265 | 1061-1064 | DT | denotes | the |
T25266 | 1065-1074 | JJ | denotes | indicated |
T25267 | 1075-1080 | NN | denotes | times |
T25268 | 1082-1087 | JJ | denotes | Total |
T25269 | 1088-1091 | NN | denotes | RNA |
T25270 | 1092-1095 | VB | denotes | was |
T25271 | 1096-1104 | VB | denotes | isolated |
T25272 | 1105-1108 | CC | denotes | and |
T25273 | 1109-1118 | VB | denotes | converted |
T25274 | 1119-1121 | TO | denotes | to |
T25275 | 1122-1126 | NN | denotes | cDNA |
T25276 | 1128-1137 | JJ | denotes | Real-time |
T25277 | 1138-1140 | NN | denotes | RT |
T25278 | 1141-1144 | NN | denotes | PCR |
T25279 | 1145-1148 | VB | denotes | was |
T25280 | 1149-1158 | VB | denotes | performed |
T25281 | 1159-1164 | VB | denotes | using |
T25282 | 1165-1172 | NN | denotes | primers |
T25283 | 1173-1176 | IN | denotes | for |
T25284 | 1177-1181 | NNP | denotes | IκBα |
T25285 | 1181-1182 | -COMMA- | denotes | , |
T25286 | 1183-1189 | NN | denotes | BCL-xl |
T25287 | 1190-1192 | CC | denotes | or |
T25288 | 1193-1198 | NN | denotes | GAPDH |
T25289 | 1200-1204 | NN | denotes | Data |
T25290 | 1205-1208 | VB | denotes | are |
T25291 | 1209-1218 | VB | denotes | expressed |
T25292 | 1219-1221 | IN | denotes | as |
T25293 | 1222-1230 | JJ | denotes | relative |
T25294 | 1231-1235 | JJ | denotes | fold |
T25295 | 1236-1244 | NN | denotes | increase |
T25296 | 1245-1247 | IN | denotes | of |
T25297 | 1248-1252 | NN | denotes | IκBα |
T25298 | 1253-1255 | CC | denotes | or |
T25299 | 1256-1262 | JJ | denotes | BCL-xl |
T25300 | 1263-1267 | NN | denotes | gene |
T25301 | 1268-1278 | NN | denotes | expression |
T25302 | 1279-1283 | IN | denotes | upon |
T25303 | 1284-1293 | NN | denotes | treatment |
T25304 | 1294-1298 | IN | denotes | over |
T25305 | 1299-1313 | JJ | denotes | non-stimulated |
T25306 | 1314-1319 | NN | denotes | cells |
T25307 | 1321-1325 | NN | denotes | Data |
T25308 | 1326-1335 | VB | denotes | represent |
T25309 | 1336-1339 | DT | denotes | the |
T25310 | 1340-1344 | JJ | denotes | mean |
T25311 | 1345-1346 | JJ | denotes | ± |
T25312 | 1347-1352 | NN | denotes | S.E.M |
T25313 | 1353-1356 | IN | denotes | for |
T25314 | 1357-1362 | CD | denotes | three |
T25315 | 1363-1374 | JJ | denotes | independent |
T25316 | 1375-1386 | NN | denotes | experiments |
R7269 | T9623 | T9622 | arg1Of | PKC,M-CSF-dependent |
R7270 | T9623 | T9624 | arg1Of | PKC,Regulates |
R7271 | T9626 | T9624 | arg2Of | Genes,Regulates |
R7272 | T9626 | T9625 | arg1Of | Genes,NF-κB-targeted |
R7273 | T9627 | T9628 | arg1Of | NF-κB,induces |
R7274 | T9630 | T9628 | arg2Of | number,induces |
R7275 | T9630 | T9629 | arg1Of | number,a |
R7276 | T9630 | T9631 | arg1Of | number,of |
R7277 | T9633 | T9631 | arg2Of | genes,of |
R7278 | T9633 | T9632 | arg1Of | genes,downstream |
R7279 | T9633 | T9634 | arg1Of | genes,"," |
R7280 | T9633 | T9635 | arg1Of | genes,including |
R7281 | T9638 | T9635 | arg2Of | family,including |
R7282 | T9638 | T9636 | arg1Of | family,the |
R7283 | T9638 | T9637 | arg1Of | family,IκB |
R7284 | T9642 | T9639 | arg2Of | molecules,Among |
R7285 | T9642 | T9640 | arg1Of | molecules,the |
R7286 | T9642 | T9641 | arg1Of | molecules,IκB |
R7287 | T9644 | T9645 | arg1Of | IκBα,is |
R7288 | T9644 | T9647 | arg2Of | IκBα,induced |
R7289 | T9647 | T9639 | arg1Of | induced,Among |
R7290 | T9647 | T9643 | arg1Of | induced,"," |
R7291 | T9647 | T9645 | arg2Of | induced,is |
R7292 | T9647 | T9646 | arg1Of | induced,highly |
R7293 | T9647 | T9651 | arg1Of | induced,[ |
R7294 | T9650 | T9647 | arg1Of | activation,induced |
R7295 | T9650 | T9648 | arg2Of | activation,by |
R7296 | T9650 | T9649 | arg1Of | activation,NF-κB |
R7297 | T9652 | T9651 | arg2Of | 40,[ |
R7298 | T9653 | T9651 | arg3Of | ],[ |
R7299 | T9655 | T9654 | arg2Of | shown,Having |
R7300 | T9657 | T9658 | arg1Of | PKC,regulated |
R7301 | T9658 | T9655 | arg2Of | regulated,shown |
R7302 | T9658 | T9656 | arg1Of | regulated,that |
R7303 | T9658 | T9661 | arg1Of | regulated,in |
R7304 | T9660 | T9658 | arg2Of | activity,regulated |
R7305 | T9660 | T9659 | arg1Of | activity,NF-κB |
R7306 | T9663 | T9661 | arg2Of | MDMs,in |
R7307 | T9663 | T9662 | arg1Of | MDMs,M-CSF-stimulated |
R7308 | T9665 | T9654 | arg1Of | we,Having |
R7309 | T9665 | T9655 | arg1Of | we,shown |
R7310 | T9665 | T9667 | arg1Of | we,determined |
R7311 | T9667 | T9654 | modOf | determined,Having |
R7312 | T9667 | T9664 | arg1Of | determined,"," |
R7313 | T9667 | T9666 | arg1Of | determined,next |
R7314 | T9669 | T9670 | arg1Of | inhibition,of |
R7315 | T9669 | T9673 | arg1Of | inhibition,decreased |
R7316 | T9672 | T9670 | arg2Of | activity,of |
R7317 | T9672 | T9671 | arg1Of | activity,PKC |
R7318 | T9673 | T9667 | arg2Of | decreased,determined |
R7319 | T9673 | T9668 | arg1Of | decreased,whether |
R7320 | T9674 | T9673 | arg2Of | expression,decreased |
R7321 | T9674 | T9675 | arg1Of | expression,of |
R7322 | T9677 | T9675 | arg2Of | genes,of |
R7323 | T9677 | T9676 | arg1Of | genes,NF-κB-regulated |
R7324 | T9678 | T9679 | arg1Of | We,treated |
R7325 | T9679 | T9686 | arg1Of | treated,with |
R7326 | T9681 | T9682 | arg1Of | MDMs,and |
R7327 | T9682 | T9679 | arg2Of | and,treated |
R7328 | T9682 | T9680 | arg1Of | and,both |
R7329 | T9685 | T9682 | arg2Of | cells,and |
R7330 | T9685 | T9683 | arg1Of | cells,RAW |
R7331 | T9685 | T9684 | arg1Of | cells,264.7 |
R7332 | T9690 | T9686 | arg2Of | Ro-31-8220,with |
R7333 | T9690 | T9687 | arg1Of | Ro-31-8220,the |
R7334 | T9690 | T9688 | arg1Of | Ro-31-8220,PKC |
R7335 | T9690 | T9689 | arg1Of | Ro-31-8220,inhibitor |
R7336 | T9690 | T9691 | arg1Of | Ro-31-8220,for |
R7337 | T9690 | T9695 | arg1Of | Ro-31-8220,then |
R7338 | T9690 | T9696 | arg2Of | Ro-31-8220,stimulated |
R7339 | T9691 | T9694 | arg1Of | for,and |
R7340 | T9693 | T9691 | arg2Of | minutes,for |
R7341 | T9693 | T9692 | arg1Of | minutes,30 |
R7342 | T9695 | T9694 | arg2Of | then,and |
R7343 | T9696 | T9697 | arg1Of | stimulated,with |
R7344 | T9698 | T9697 | arg2Of | M-CSF,with |
R7345 | T9700 | T9699 | arg1Of | gene,IκBα |
R7346 | T9700 | T9701 | arg1Of | gene,was |
R7347 | T9700 | T9702 | arg2Of | gene,measured |
R7348 | T9702 | T9701 | arg2Of | measured,was |
R7349 | T9704 | T9702 | arg1Of | qRT-PCR,measured |
R7350 | T9704 | T9703 | arg2Of | qRT-PCR,by |
R7351 | T9706 | T9705 | arg2Of | shown,As |
R7352 | T9706 | T9707 | arg1Of | shown,in |
R7353 | T9709 | T9710 | arg1Of | 6A,and |
R7354 | T9710 | T9707 | arg2Of | and,in |
R7355 | T9710 | T9708 | arg1Of | and,Figures |
R7356 | T9710 | T9712 | arg1Of | and,"," |
R7357 | T9711 | T9710 | arg2Of | 6B,and |
R7358 | T9713 | T9712 | arg2Of | M-CSF,"," |
R7359 | T9717 | T9715 | arg1Of | expression,IκBα |
R7360 | T9717 | T9716 | arg1Of | expression,gene |
R7361 | T9717 | T9718 | arg1Of | expression,and |
R7362 | T9718 | T9714 | arg2Of | and,enhanced |
R7363 | T9718 | T9721 | arg1Of | and,by |
R7364 | T9718 | T9723 | arg1Of | and,decreased |
R7365 | T9720 | T9718 | arg2Of | inhibition,and |
R7366 | T9720 | T9719 | arg1Of | inhibition,PKC |
R7367 | T9722 | T9721 | arg2Of | Ro-31-8220,by |
R7368 | T9723 | T9705 | arg1Of | decreased,As |
R7369 | T9723 | T9739 | arg1Of | decreased,"," |
R7370 | T9723 | T9740 | modOf | decreased,demonstrating |
R7371 | T9726 | T9723 | arg2Of | expression,decreased |
R7372 | T9726 | T9724 | arg1Of | expression,IκBα |
R7373 | T9726 | T9725 | arg1Of | expression,gene |
R7374 | T9726 | T9727 | arg1Of | expression,in |
R7375 | T9729 | T9730 | arg1Of | MDMs,and |
R7376 | T9730 | T9727 | arg2Of | and,in |
R7377 | T9730 | T9728 | arg1Of | and,both |
R7378 | T9730 | T9734 | arg1Of | and,( |
R7379 | T9733 | T9730 | arg2Of | cells,and |
R7380 | T9733 | T9731 | arg1Of | cells,RAW |
R7381 | T9733 | T9732 | arg1Of | cells,264.7 |
R7382 | T9735 | T9734 | arg2Of | p,( |
R7383 | T9735 | T9736 | arg1Of | p,< |
R7384 | T9735 | T9737 | arg1Of | p,0.01 |
R7385 | T9738 | T9734 | arg3Of | ),( |
R7386 | T9742 | T9743 | arg1Of | PKC,affected |
R7387 | T9743 | T9740 | arg2Of | affected,demonstrating |
R7388 | T9743 | T9741 | arg1Of | affected,that |
R7389 | T9746 | T9743 | arg2Of | expression,affected |
R7390 | T9746 | T9744 | arg1Of | expression,NF-κB-regulated |
R7391 | T9746 | T9745 | arg1Of | expression,gene |
R7392 | T9746 | T9747 | arg1Of | expression,in |
R7393 | T9748 | T9747 | arg2Of | macrophages,in |
R7394 | T9751 | T9749 | arg1Of | define,To |
R7395 | T9751 | T9750 | arg1Of | define,further |
R7396 | T9753 | T9751 | arg2Of | role,define |
R7397 | T9753 | T9752 | arg1Of | role,the |
R7398 | T9753 | T9754 | arg1Of | role,of |
R7399 | T9753 | T9756 | arg1Of | role,in |
R7400 | T9755 | T9754 | arg2Of | PKC,of |
R7401 | T9757 | T9756 | arg2Of | mediating,in |
R7402 | T9757 | T9761 | arg1Of | mediating,in |
R7403 | T9760 | T9757 | arg2Of | survival,mediating |
R7404 | T9760 | T9758 | arg1Of | survival,human |
R7405 | T9760 | T9759 | arg1Of | survival,MDM |
R7406 | T9761 | T9763 | arg1Of | in,to |
R7407 | T9762 | T9761 | arg2Of | response,in |
R7408 | T9764 | T9761 | arg3Of | M-CSF,in |
R7409 | T9766 | T9751 | arg1Of | we,define |
R7410 | T9766 | T9767 | arg1Of | we,examined |
R7411 | T9767 | T9749 | modOf | examined,To |
R7412 | T9767 | T9765 | arg1Of | examined,"," |
R7413 | T9769 | T9767 | arg2Of | expression,examined |
R7414 | T9769 | T9768 | arg1Of | expression,the |
R7415 | T9769 | T9770 | arg1Of | expression,of |
R7416 | T9774 | T9770 | arg2Of | BCL-xL,of |
R7417 | T9774 | T9771 | arg1Of | BCL-xL,the |
R7418 | T9774 | T9772 | arg1Of | BCL-xL,anti-apoptotic |
R7419 | T9774 | T9773 | arg1Of | BCL-xL,gene |
R7420 | T9774 | T9775 | arg1Of | BCL-xL,"," |
R7421 | T9774 | T9776 | arg1Of | BCL-xL,which |
R7422 | T9774 | T9777 | arg1Of | BCL-xL,is |
R7423 | T9774 | T9779 | arg2Of | BCL-xL,regulated |
R7424 | T9779 | T9777 | arg2Of | regulated,is |
R7425 | T9779 | T9778 | arg1Of | regulated,also |
R7426 | T9781 | T9779 | arg1Of | NF-κB,regulated |
R7427 | T9781 | T9780 | arg2Of | NF-κB,by |
R7428 | T9783 | T9782 | arg2Of | shown,As |
R7429 | T9783 | T9784 | arg1Of | shown,in |
R7430 | T9786 | T9784 | arg2Of | 6C,in |
R7431 | T9786 | T9785 | arg1Of | 6C,Figure |
R7432 | T9788 | T9789 | arg1Of | Ro-31-8220,reduced |
R7433 | T9789 | T9782 | arg1Of | reduced,As |
R7434 | T9789 | T9787 | arg1Of | reduced,"," |
R7435 | T9789 | T9793 | arg1Of | reduced,compared |
R7436 | T9792 | T9789 | arg2Of | expression,reduced |
R7437 | T9792 | T9790 | arg1Of | expression,M-CSF-stimulated |
R7438 | T9792 | T9791 | arg1Of | expression,BCL-xL |
R7439 | T9794 | T9793 | arg2Of | to,compared |
R7440 | T9795 | T9796 | arg2Of | cells,treated |
R7441 | T9795 | T9799 | arg1Of | cells,and |
R7442 | T9796 | T9797 | arg1Of | treated,with |
R7443 | T9798 | T9797 | arg2Of | M-CSF,with |
R7444 | T9799 | T9794 | arg2Of | and,to |
R7445 | T9803 | T9799 | arg2Of | DMSO,and |
R7446 | T9803 | T9800 | arg1Of | DMSO,the |
R7447 | T9803 | T9801 | arg1Of | DMSO,vehicle |
R7448 | T9803 | T9802 | arg1Of | DMSO,control |
R7449 | T9803 | T9804 | arg1Of | DMSO,( |
R7450 | T9805 | T9804 | arg2Of | p,( |
R7451 | T9805 | T9806 | arg1Of | p,< |
R7452 | T9805 | T9807 | arg1Of | p,0.05 |
R7453 | T9808 | T9804 | arg3Of | ),( |
R19278 | T25222 | T25223 | arg1Of | Inhibition,of |
R19279 | T25222 | T25226 | arg1Of | Inhibition,reduces |
R19280 | T25225 | T25223 | arg2Of | PKC,of |
R19281 | T25225 | T25224 | arg1Of | PKC,M-CSF-induced |
R19282 | T25226 | T25229 | arg1Of | reduces,in |
R19283 | T25228 | T25226 | arg2Of | genes,reduces |
R19284 | T25228 | T25227 | arg1Of | genes,NF-κB-regulated |
R19285 | T25231 | T25232 | arg1Of | MDMs,and |
R19286 | T25232 | T25229 | arg2Of | and,in |
R19287 | T25232 | T25230 | arg1Of | and,both |
R19288 | T25235 | T25232 | arg2Of | cells,and |
R19289 | T25235 | T25233 | arg1Of | cells,RAW |
R19290 | T25235 | T25234 | arg1Of | cells,264.7 |
R19291 | T25236 | T25237 | arg1Of | MDMs,( |
R19292 | T25236 | T25242 | arg1Of | MDMs,and |
R19293 | T25238 | T25239 | arg1Of | A,and |
R19294 | T25239 | T25237 | arg2Of | and,( |
R19295 | T25240 | T25239 | arg2Of | C,and |
R19296 | T25241 | T25237 | arg3Of | ),( |
R19297 | T25242 | T25249 | arg1Of | and,were |
R19298 | T25242 | T25250 | arg2Of | and,pretreated |
R19299 | T25243 | T25244 | arg1Of | RAW,264.7 |
R19300 | T25243 | T25245 | arg1Of | RAW,( |
R19301 | T25246 | T25245 | arg2Of | B,( |
R19302 | T25247 | T25245 | arg3Of | ),( |
R19303 | T25248 | T25242 | arg2Of | cells,and |
R19304 | T25248 | T25243 | arg1Of | cells,RAW |
R19305 | T25250 | T25249 | arg2Of | pretreated,were |
R19306 | T25250 | T25251 | arg1Of | pretreated,with |
R19307 | T25250 | T25257 | arg1Of | pretreated,for |
R19308 | T25252 | T25253 | arg1Of | Ro-31-8220,or |
R19309 | T25253 | T25251 | arg2Of | or,with |
R19310 | T25256 | T25253 | arg2Of | DMSO,or |
R19311 | T25256 | T25254 | arg1Of | DMSO,solvent |
R19312 | T25256 | T25255 | arg1Of | DMSO,control |
R19313 | T25259 | T25257 | arg2Of | minutes,for |
R19314 | T25259 | T25258 | arg1Of | minutes,30 |
R19315 | T25259 | T25261 | arg1Of | minutes,to |
R19316 | T25261 | T25260 | arg1Of | to,prior |
R19317 | T25263 | T25261 | arg2Of | stimulation,to |
R19318 | T25263 | T25262 | arg1Of | stimulation,M-CSF |
R19319 | T25263 | T25264 | arg1Of | stimulation,for |
R19320 | T25267 | T25264 | arg2Of | times,for |
R19321 | T25267 | T25265 | arg1Of | times,the |
R19322 | T25267 | T25266 | arg1Of | times,indicated |
R19323 | T25269 | T25268 | arg1Of | RNA,Total |
R19324 | T25269 | T25270 | arg1Of | RNA,was |
R19325 | T25269 | T25271 | arg2Of | RNA,isolated |
R19326 | T25269 | T25273 | arg2Of | RNA,converted |
R19327 | T25271 | T25272 | arg1Of | isolated,and |
R19328 | T25272 | T25270 | arg2Of | and,was |
R19329 | T25273 | T25272 | arg2Of | converted,and |
R19330 | T25273 | T25274 | arg1Of | converted,to |
R19331 | T25275 | T25274 | arg2Of | cDNA,to |
R19332 | T25278 | T25276 | arg1Of | PCR,Real-time |
R19333 | T25278 | T25277 | arg1Of | PCR,RT |
R19334 | T25278 | T25279 | arg1Of | PCR,was |
R19335 | T25278 | T25280 | arg2Of | PCR,performed |
R19336 | T25280 | T25279 | arg2Of | performed,was |
R19337 | T25281 | T25280 | arg3Of | using,performed |
R19338 | T25282 | T25281 | arg2Of | primers,using |
R19339 | T25282 | T25283 | arg1Of | primers,for |
R19340 | T25284 | T25285 | arg1Of | IκBα,"," |
R19341 | T25285 | T25287 | arg1Of | ",",or |
R19342 | T25286 | T25285 | arg2Of | BCL-xl,"," |
R19343 | T25287 | T25283 | arg2Of | or,for |
R19344 | T25288 | T25287 | arg2Of | GAPDH,or |
R19345 | T25289 | T25290 | arg1Of | Data,are |
R19346 | T25289 | T25291 | arg2Of | Data,expressed |
R19347 | T25291 | T25290 | arg2Of | expressed,are |
R19348 | T25291 | T25292 | arg1Of | expressed,as |
R19349 | T25294 | T25293 | arg1Of | fold,relative |
R19350 | T25295 | T25292 | arg2Of | increase,as |
R19351 | T25295 | T25294 | arg1Of | increase,fold |
R19352 | T25295 | T25296 | arg1Of | increase,of |
R19353 | T25297 | T25298 | arg1Of | IκBα,or |
R19354 | T25299 | T25298 | arg2Of | BCL-xl,or |
R19355 | T25301 | T25296 | arg2Of | expression,of |
R19356 | T25301 | T25297 | arg1Of | expression,IκBα |
R19357 | T25301 | T25299 | arg1Of | expression,BCL-xl |
R19358 | T25301 | T25300 | arg1Of | expression,gene |
R19359 | T25301 | T25302 | arg1Of | expression,upon |
R19360 | T25301 | T25304 | arg1Of | expression,over |
R19361 | T25303 | T25302 | arg2Of | treatment,upon |
R19362 | T25306 | T25304 | arg2Of | cells,over |
R19363 | T25306 | T25305 | arg1Of | cells,non-stimulated |
R19364 | T25307 | T25308 | arg1Of | Data,represent |
R19365 | T25312 | T25308 | arg2Of | S.E.M,represent |
R19366 | T25312 | T25309 | arg1Of | S.E.M,the |
R19367 | T25312 | T25310 | arg1Of | S.E.M,mean |
R19368 | T25312 | T25311 | arg1Of | S.E.M,± |
R19369 | T25312 | T25313 | arg1Of | S.E.M,for |
R19370 | T25316 | T25313 | arg2Of | experiments,for |
R19371 | T25316 | T25314 | arg1Of | experiments,three |
R19372 | T25316 | T25315 | arg1Of | experiments,independent |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T9418 | 0-50 | Sentence | denotes | M-CSF-dependent PKC Regulates NF-κB-targeted Genes |
T9419 | 51-120 | Sentence | denotes | NF-κB induces a number of downstream genes, including the IκB family. |
T9420 | 121-194 | Sentence | denotes | Among the IκB molecules, IκBα is highly induced by NF-κB activation [40]. |
T9421 | 195-368 | Sentence | denotes | Having shown that PKC regulated NF-κB activity in M-CSF-stimulated MDMs, we next determined whether inhibition of PKC activity decreased expression of NF-κB-regulated genes. |
T9422 | 369-490 | Sentence | denotes | We treated both MDMs and RAW 264.7 cells with the PKC inhibitor Ro-31-8220 for 30 minutes and then stimulated with M-CSF. |
T9423 | 491-525 | Sentence | denotes | IκBα gene was measured by qRT-PCR. |
T9424 | 526-779 | Sentence | denotes | As shown in Figures 6A and 6B, M-CSF enhanced IκBα gene expression and PKC inhibition by Ro-31-8220 decreased IκBα gene expression in both MDMs and RAW 264.7 cells (p<0.01), demonstrating that PKC affected NF-κB-regulated gene expression in macrophages. |
T9425 | 1390-1573 | Sentence | denotes | To further define the role of PKC in mediating human MDM survival in response to M-CSF, we examined the expression of the anti-apoptotic gene BCL-xL, which is also regulated by NF-κB. |
T9426 | 1574-1726 | Sentence | denotes | As shown in Figure 6C, Ro-31-8220 reduced M-CSF-stimulated BCL-xL expression compared to cells treated with M-CSF and the vehicle control DMSO (p<0.05). |
T25115 | 824-919 | Sentence | denotes | Inhibition of M-CSF-induced PKC reduces NF-κB-regulated genes in both MDMs and RAW 264.7 cells. |
T25116 | 920-1081 | Sentence | denotes | MDMs (A and C) and RAW 264.7 (B) cells were pretreated with Ro-31-8220 or solvent control DMSO for 30 minutes prior to M-CSF stimulation for the indicated times. |
T25117 | 1082-1127 | Sentence | denotes | Total RNA was isolated and converted to cDNA. |
T25118 | 1128-1199 | Sentence | denotes | Real-time RT PCR was performed using primers for IκBα, BCL-xl or GAPDH. |
T25119 | 1200-1320 | Sentence | denotes | Data are expressed as relative fold increase of IκBα or BCL-xl gene expression upon treatment over non-stimulated cells. |
T25120 | 1321-1387 | Sentence | denotes | Data represent the mean ± S.E.M for three independent experiments. |
T152 | 0-50 | Sentence | denotes | M-CSF-dependent PKC Regulates NF-κB-targeted Genes |
T153 | 51-120 | Sentence | denotes | NF-κB induces a number of downstream genes, including the IκB family. |
T154 | 121-194 | Sentence | denotes | Among the IκB molecules, IκBα is highly induced by NF-κB activation [40]. |
T155 | 195-368 | Sentence | denotes | Having shown that PKC regulated NF-κB activity in M-CSF-stimulated MDMs, we next determined whether inhibition of PKC activity decreased expression of NF-κB-regulated genes. |
T156 | 369-490 | Sentence | denotes | We treated both MDMs and RAW 264.7 cells with the PKC inhibitor Ro-31-8220 for 30 minutes and then stimulated with M-CSF. |
T157 | 491-525 | Sentence | denotes | IκBα gene was measured by qRT-PCR. |
T158 | 526-779 | Sentence | denotes | As shown in Figures 6A and 6B, M-CSF enhanced IκBα gene expression and PKC inhibition by Ro-31-8220 decreased IκBα gene expression in both MDMs and RAW 264.7 cells (p<0.01), demonstrating that PKC affected NF-κB-regulated gene expression in macrophages. |
T159 | 780-919 | Sentence | denotes | 10.1371/journal.pone.0028081.g006 Figure 6 Inhibition of M-CSF-induced PKC reduces NF-κB-regulated genes in both MDMs and RAW 264.7 cells. |
T160 | 920-1081 | Sentence | denotes | MDMs (A and C) and RAW 264.7 (B) cells were pretreated with Ro-31-8220 or solvent control DMSO for 30 minutes prior to M-CSF stimulation for the indicated times. |
T161 | 1082-1127 | Sentence | denotes | Total RNA was isolated and converted to cDNA. |
T162 | 1128-1199 | Sentence | denotes | Real-time RT PCR was performed using primers for IκBα, BCL-xl or GAPDH. |
T163 | 1200-1320 | Sentence | denotes | Data are expressed as relative fold increase of IκBα or BCL-xl gene expression upon treatment over non-stimulated cells. |
T164 | 1321-1387 | Sentence | denotes | Data represent the mean ± S.E.M for three independent experiments. |
T165 | 1390-1573 | Sentence | denotes | To further define the role of PKC in mediating human MDM survival in response to M-CSF, we examined the expression of the anti-apoptotic gene BCL-xL, which is also regulated by NF-κB. |
T166 | 1574-1726 | Sentence | denotes | As shown in Figure 6C, Ro-31-8220 reduced M-CSF-stimulated BCL-xL expression compared to cells treated with M-CSF and the vehicle control DMSO (p<0.05). |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
22216091-8319912-90609715 | 190-192 | 8319912 | denotes | 40 |
bionlp-st-ge-2016-spacy-parsed
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T9427 | 0-15 | JJ | denotes | M-CSF-dependent |
T9428 | 16-19 | NNP | denotes | PKC |
T9429 | 20-29 | VBZ | denotes | Regulates |
T9430 | 30-44 | JJ | denotes | NF-κB-targeted |
T9431 | 45-50 | NNS | denotes | Genes |
T9432 | 51-56 | JJ | denotes | NF-κB |
T9433 | 57-64 | VBZ | denotes | induces |
T9434 | 65-66 | DT | denotes | a |
T9435 | 67-73 | NN | denotes | number |
T9436 | 74-76 | IN | denotes | of |
T9437 | 77-87 | JJ | denotes | downstream |
T9438 | 88-93 | NNS | denotes | genes |
T9439 | 93-94 | , | denotes | , |
T9440 | 95-104 | VBG | denotes | including |
T9441 | 105-108 | DT | denotes | the |
T9442 | 109-112 | NNP | denotes | IκB |
T9443 | 113-119 | NN | denotes | family |
T9444 | 119-120 | . | denotes | . |
T9445 | 121-126 | IN | denotes | Among |
T9446 | 127-130 | DT | denotes | the |
T9447 | 131-134 | NNP | denotes | IκB |
T9448 | 135-144 | NNS | denotes | molecules |
T9449 | 144-145 | , | denotes | , |
T9450 | 146-150 | NNP | denotes | IκBα |
T9451 | 151-153 | VBZ | denotes | is |
T9452 | 154-160 | RB | denotes | highly |
T9453 | 161-168 | VBN | denotes | induced |
T9454 | 169-171 | IN | denotes | by |
T9455 | 172-177 | JJ | denotes | NF-κB |
T9456 | 178-188 | NN | denotes | activation |
T9457 | 189-190 | NNP | denotes | [ |
T9458 | 190-192 | CD | denotes | 40 |
T9459 | 192-193 | NNP | denotes | ] |
T9460 | 193-194 | . | denotes | . |
T9461 | 195-201 | VBG | denotes | Having |
T9462 | 202-207 | VBN | denotes | shown |
T9463 | 208-212 | IN | denotes | that |
T9464 | 213-216 | NNP | denotes | PKC |
T9465 | 217-226 | VBD | denotes | regulated |
T9466 | 227-232 | JJ | denotes | NF-κB |
T9467 | 233-241 | NN | denotes | activity |
T9468 | 242-244 | IN | denotes | in |
T9469 | 245-261 | JJ | denotes | M-CSF-stimulated |
T9470 | 262-266 | NNS | denotes | MDMs |
T9471 | 266-267 | , | denotes | , |
T9472 | 268-270 | PRP | denotes | we |
T9473 | 271-275 | JJ | denotes | next |
T9474 | 276-286 | VBN | denotes | determined |
T9475 | 287-294 | IN | denotes | whether |
T9476 | 295-305 | NN | denotes | inhibition |
T9477 | 306-308 | IN | denotes | of |
T9478 | 309-312 | NNP | denotes | PKC |
T9479 | 313-321 | NN | denotes | activity |
T9480 | 322-331 | VBD | denotes | decreased |
T9481 | 332-342 | NN | denotes | expression |
T9482 | 343-345 | IN | denotes | of |
T9483 | 346-361 | JJ | denotes | NF-κB-regulated |
T9484 | 362-367 | NNS | denotes | genes |
T9485 | 367-368 | . | denotes | . |
T9486 | 369-371 | PRP | denotes | We |
T9487 | 372-379 | VBD | denotes | treated |
T9488 | 380-384 | DT | denotes | both |
T9489 | 385-389 | NNS | denotes | MDMs |
T9490 | 390-393 | CC | denotes | and |
T9491 | 394-397 | NNP | denotes | RAW |
T9492 | 398-403 | CD | denotes | 264.7 |
T9493 | 404-409 | NNS | denotes | cells |
T9494 | 410-414 | IN | denotes | with |
T9495 | 415-418 | DT | denotes | the |
T9496 | 419-422 | NNP | denotes | PKC |
T9497 | 423-432 | NN | denotes | inhibitor |
T9498 | 433-443 | NN | denotes | Ro-31-8220 |
T9499 | 444-447 | IN | denotes | for |
T9500 | 448-450 | CD | denotes | 30 |
T9501 | 451-458 | NNS | denotes | minutes |
T9502 | 459-462 | CC | denotes | and |
T9503 | 463-467 | RB | denotes | then |
T9504 | 468-478 | VBN | denotes | stimulated |
T9505 | 479-483 | IN | denotes | with |
T9506 | 484-489 | NNP | denotes | M-CSF |
T9507 | 489-490 | . | denotes | . |
T9508 | 491-495 | NNP | denotes | IκBα |
T9509 | 496-500 | NN | denotes | gene |
T9510 | 501-504 | VBD | denotes | was |
T9511 | 505-513 | VBN | denotes | measured |
T9512 | 514-516 | IN | denotes | by |
T9513 | 517-524 | NNP | denotes | qRT-PCR |
T9514 | 524-525 | . | denotes | . |
T9515 | 526-528 | IN | denotes | As |
T9516 | 529-534 | VBN | denotes | shown |
T9517 | 535-537 | IN | denotes | in |
T9518 | 538-545 | NNS | denotes | Figures |
T9519 | 546-548 | NNP | denotes | 6A |
T9520 | 549-552 | CC | denotes | and |
T9521 | 553-555 | NNP | denotes | 6B |
T9522 | 555-556 | , | denotes | , |
T9523 | 557-562 | NNP | denotes | M-CSF |
T9524 | 563-571 | VBD | denotes | enhanced |
T9525 | 572-576 | NNP | denotes | IκBα |
T9526 | 577-581 | NN | denotes | gene |
T9527 | 582-592 | NN | denotes | expression |
T9528 | 593-596 | CC | denotes | and |
T9529 | 597-600 | NNP | denotes | PKC |
T9530 | 601-611 | NN | denotes | inhibition |
T9531 | 612-614 | IN | denotes | by |
T9532 | 615-625 | JJ | denotes | Ro-31-8220 |
T9533 | 626-635 | VBN | denotes | decreased |
T9534 | 636-640 | NNP | denotes | IκBα |
T9535 | 641-645 | NN | denotes | gene |
T9536 | 646-656 | NN | denotes | expression |
T9537 | 657-659 | IN | denotes | in |
T9538 | 660-664 | DT | denotes | both |
T9539 | 665-669 | NNS | denotes | MDMs |
T9540 | 670-673 | CC | denotes | and |
T9541 | 674-677 | NNP | denotes | RAW |
T9542 | 678-683 | CD | denotes | 264.7 |
T9543 | 684-689 | NNS | denotes | cells |
T9544 | 690-691 | -LRB- | denotes | ( |
T9545 | 691-692 | FW | denotes | p |
T9546 | 692-693 | FW | denotes | < |
T9547 | 693-697 | CD | denotes | 0.01 |
T9548 | 697-698 | -RRB- | denotes | ) |
T9549 | 698-699 | , | denotes | , |
T9550 | 700-713 | VBG | denotes | demonstrating |
T9551 | 714-718 | IN | denotes | that |
T9552 | 719-722 | NNP | denotes | PKC |
T9553 | 723-731 | VBD | denotes | affected |
T9554 | 732-747 | JJ | denotes | NF-κB-regulated |
T9555 | 748-752 | NN | denotes | gene |
T9556 | 753-763 | NN | denotes | expression |
T9557 | 764-766 | IN | denotes | in |
T9558 | 767-778 | NNS | denotes | macrophages |
T9559 | 778-779 | . | denotes | . |
T9560 | 1390-1392 | TO | denotes | To |
T9561 | 1393-1400 | RBR | denotes | further |
T9562 | 1401-1407 | VB | denotes | define |
T9563 | 1408-1411 | DT | denotes | the |
T9564 | 1412-1416 | NN | denotes | role |
T9565 | 1417-1419 | IN | denotes | of |
T9566 | 1420-1423 | NNP | denotes | PKC |
T9567 | 1424-1426 | IN | denotes | in |
T9568 | 1427-1436 | VBG | denotes | mediating |
T9569 | 1437-1442 | JJ | denotes | human |
T9570 | 1443-1446 | NNP | denotes | MDM |
T9571 | 1447-1455 | NN | denotes | survival |
T9572 | 1456-1458 | IN | denotes | in |
T9573 | 1459-1467 | NN | denotes | response |
T9574 | 1468-1470 | TO | denotes | to |
T9575 | 1471-1476 | NNP | denotes | M-CSF |
T9576 | 1476-1477 | , | denotes | , |
T9577 | 1478-1480 | PRP | denotes | we |
T9578 | 1481-1489 | VBD | denotes | examined |
T9579 | 1490-1493 | DT | denotes | the |
T9580 | 1494-1504 | NN | denotes | expression |
T9581 | 1505-1507 | IN | denotes | of |
T9582 | 1508-1511 | DT | denotes | the |
T9583 | 1512-1526 | JJ | denotes | anti-apoptotic |
T9584 | 1527-1531 | NN | denotes | gene |
T9585 | 1532-1538 | NNP | denotes | BCL-xL |
T9586 | 1538-1539 | , | denotes | , |
T9587 | 1540-1545 | WDT | denotes | which |
T9588 | 1546-1548 | VBZ | denotes | is |
T9589 | 1549-1553 | RB | denotes | also |
T9590 | 1554-1563 | VBN | denotes | regulated |
T9591 | 1564-1566 | IN | denotes | by |
T9592 | 1567-1572 | NNP | denotes | NF-κB |
T9593 | 1572-1573 | . | denotes | . |
T9594 | 1574-1576 | IN | denotes | As |
T9595 | 1577-1582 | VBN | denotes | shown |
T9596 | 1583-1585 | IN | denotes | in |
T9597 | 1586-1592 | NNP | denotes | Figure |
T9598 | 1593-1595 | NNP | denotes | 6C |
T9599 | 1595-1596 | , | denotes | , |
T9600 | 1597-1607 | NNP | denotes | Ro-31-8220 |
T9601 | 1608-1615 | VBD | denotes | reduced |
T9602 | 1616-1632 | JJ | denotes | M-CSF-stimulated |
T9603 | 1633-1639 | JJ | denotes | BCL-xL |
T9604 | 1640-1650 | NN | denotes | expression |
T9605 | 1651-1659 | VBN | denotes | compared |
T9606 | 1660-1662 | TO | denotes | to |
T9607 | 1663-1668 | NNS | denotes | cells |
T9608 | 1669-1676 | VBN | denotes | treated |
T9609 | 1677-1681 | IN | denotes | with |
T9610 | 1682-1687 | NNP | denotes | M-CSF |
T9611 | 1688-1691 | CC | denotes | and |
T9612 | 1692-1695 | DT | denotes | the |
T9613 | 1696-1703 | NN | denotes | vehicle |
T9614 | 1704-1711 | NN | denotes | control |
T9615 | 1712-1716 | NNP | denotes | DMSO |
T9616 | 1717-1718 | -LRB- | denotes | ( |
T9617 | 1718-1719 | JJ | denotes | p |
T9618 | 1719-1720 | NN | denotes | < |
T9619 | 1720-1724 | CD | denotes | 0.05 |
T9620 | 1724-1725 | -RRB- | denotes | ) |
T9621 | 1725-1726 | . | denotes | . |
T25121 | 824-834 | NNP | denotes | Inhibition |
T25122 | 835-837 | IN | denotes | of |
T25123 | 838-851 | NNP | denotes | M-CSF-induced |
T25124 | 852-855 | NNP | denotes | PKC |
T25125 | 856-863 | VBZ | denotes | reduces |
T25126 | 864-879 | JJ | denotes | NF-κB-regulated |
T25127 | 880-885 | NNS | denotes | genes |
T25128 | 886-888 | IN | denotes | in |
T25129 | 889-893 | DT | denotes | both |
T25130 | 894-898 | NNS | denotes | MDMs |
T25131 | 899-902 | CC | denotes | and |
T25132 | 903-906 | NNP | denotes | RAW |
T25133 | 907-912 | CD | denotes | 264.7 |
T25134 | 913-918 | NNS | denotes | cells |
T25135 | 918-919 | . | denotes | . |
T25136 | 920-924 | NNS | denotes | MDMs |
T25137 | 925-926 | -LRB- | denotes | ( |
T25138 | 926-927 | DT | denotes | A |
T25139 | 928-931 | CC | denotes | and |
T25140 | 932-933 | NNP | denotes | C |
T25141 | 933-934 | -RRB- | denotes | ) |
T25142 | 935-938 | CC | denotes | and |
T25143 | 939-942 | NNP | denotes | RAW |
T25144 | 943-948 | CD | denotes | 264.7 |
T25145 | 949-950 | -LRB- | denotes | ( |
T25146 | 950-951 | NN | denotes | B |
T25147 | 951-952 | -RRB- | denotes | ) |
T25148 | 953-958 | NNS | denotes | cells |
T25149 | 959-963 | VBD | denotes | were |
T25150 | 964-974 | VBN | denotes | pretreated |
T25151 | 975-979 | IN | denotes | with |
T25152 | 980-990 | NN | denotes | Ro-31-8220 |
T25153 | 991-993 | CC | denotes | or |
T25154 | 994-1001 | JJ | denotes | solvent |
T25155 | 1002-1009 | NN | denotes | control |
T25156 | 1010-1014 | NNP | denotes | DMSO |
T25157 | 1015-1018 | IN | denotes | for |
T25158 | 1019-1021 | CD | denotes | 30 |
T25159 | 1022-1029 | NNS | denotes | minutes |
T25160 | 1030-1035 | RB | denotes | prior |
T25161 | 1036-1038 | TO | denotes | to |
T25162 | 1039-1044 | NNP | denotes | M-CSF |
T25163 | 1045-1056 | NN | denotes | stimulation |
T25164 | 1057-1060 | IN | denotes | for |
T25165 | 1061-1064 | DT | denotes | the |
T25166 | 1065-1074 | JJ | denotes | indicated |
T25167 | 1075-1080 | NNS | denotes | times |
T25168 | 1080-1081 | . | denotes | . |
T25169 | 1082-1087 | JJ | denotes | Total |
T25170 | 1088-1091 | NNP | denotes | RNA |
T25171 | 1092-1095 | VBD | denotes | was |
T25172 | 1096-1104 | VBN | denotes | isolated |
T25173 | 1105-1108 | CC | denotes | and |
T25174 | 1109-1118 | VBN | denotes | converted |
T25175 | 1119-1121 | TO | denotes | to |
T25176 | 1122-1126 | NNP | denotes | cDNA |
T25177 | 1126-1127 | . | denotes | . |
T25178 | 1128-1137 | JJ | denotes | Real-time |
T25179 | 1138-1140 | NNP | denotes | RT |
T25180 | 1141-1144 | NNP | denotes | PCR |
T25181 | 1145-1148 | VBD | denotes | was |
T25182 | 1149-1158 | VBN | denotes | performed |
T25183 | 1159-1164 | VBG | denotes | using |
T25184 | 1165-1172 | NNS | denotes | primers |
T25185 | 1173-1176 | IN | denotes | for |
T25186 | 1177-1181 | NNP | denotes | IκBα |
T25187 | 1181-1182 | , | denotes | , |
T25188 | 1183-1189 | NNP | denotes | BCL-xl |
T25189 | 1190-1192 | CC | denotes | or |
T25190 | 1193-1198 | NNP | denotes | GAPDH |
T25191 | 1198-1199 | . | denotes | . |
T25192 | 1200-1204 | NNS | denotes | Data |
T25193 | 1205-1208 | VBP | denotes | are |
T25194 | 1209-1218 | VBN | denotes | expressed |
T25195 | 1219-1221 | IN | denotes | as |
T25196 | 1222-1230 | JJ | denotes | relative |
T25197 | 1231-1235 | VBP | denotes | fold |
T25198 | 1236-1244 | NN | denotes | increase |
T25199 | 1245-1247 | IN | denotes | of |
T25200 | 1248-1252 | NNP | denotes | IκBα |
T25201 | 1253-1255 | CC | denotes | or |
T25202 | 1256-1262 | NNP | denotes | BCL-xl |
T25203 | 1263-1267 | NN | denotes | gene |
T25204 | 1268-1278 | NN | denotes | expression |
T25205 | 1279-1283 | IN | denotes | upon |
T25206 | 1284-1293 | NN | denotes | treatment |
T25207 | 1294-1298 | IN | denotes | over |
T25208 | 1299-1313 | JJ | denotes | non-stimulated |
T25209 | 1314-1319 | NNS | denotes | cells |
T25210 | 1319-1320 | . | denotes | . |
T25211 | 1321-1325 | NNP | denotes | Data |
T25212 | 1326-1335 | VBP | denotes | represent |
T25213 | 1336-1339 | DT | denotes | the |
T25214 | 1340-1344 | JJ | denotes | mean |
T25215 | 1345-1346 | NN | denotes | ± |
T25216 | 1347-1352 | NNP | denotes | S.E.M |
T25217 | 1353-1356 | IN | denotes | for |
T25218 | 1357-1362 | CD | denotes | three |
T25219 | 1363-1374 | JJ | denotes | independent |
T25220 | 1375-1386 | NNS | denotes | experiments |
T25221 | 1386-1387 | . | denotes | . |
R7074 | T9427 | T9428 | compound | M-CSF-dependent,PKC |
R7075 | T9428 | T9429 | nsubj | PKC,Regulates |
R7076 | T9429 | T9429 | ROOT | Regulates,Regulates |
R7077 | T9430 | T9431 | compound | NF-κB-targeted,Genes |
R7078 | T9431 | T9432 | compound | Genes,NF-κB |
R7079 | T9432 | T9433 | nsubj | NF-κB,induces |
R7080 | T9433 | T9429 | ccomp | induces,Regulates |
R7081 | T9434 | T9435 | det | a,number |
R7082 | T9435 | T9433 | dobj | number,induces |
R7083 | T9436 | T9435 | prep | of,number |
R7084 | T9437 | T9438 | amod | downstream,genes |
R7085 | T9438 | T9436 | pobj | genes,of |
R7086 | T9439 | T9438 | punct | ",",genes |
R7087 | T9440 | T9438 | prep | including,genes |
R7088 | T9441 | T9443 | det | the,family |
R7089 | T9442 | T9443 | compound | IκB,family |
R7090 | T9443 | T9440 | pobj | family,including |
R7091 | T9444 | T9429 | punct | .,Regulates |
R7092 | T9445 | T9453 | prep | Among,induced |
R7093 | T9446 | T9448 | det | the,molecules |
R7094 | T9447 | T9448 | compound | IκB,molecules |
R7095 | T9448 | T9445 | pobj | molecules,Among |
R7096 | T9449 | T9453 | punct | ",",induced |
R7097 | T9450 | T9453 | nsubjpass | IκBα,induced |
R7098 | T9451 | T9453 | auxpass | is,induced |
R7099 | T9452 | T9453 | advmod | highly,induced |
R7100 | T9453 | T9453 | ROOT | induced,induced |
R7101 | T9454 | T9453 | agent | by,induced |
R7102 | T9455 | T9456 | amod | NF-κB,activation |
R7103 | T9456 | T9459 | nmod | activation,] |
R7104 | T9457 | T9459 | nmod | [,] |
R7105 | T9458 | T9459 | nummod | 40,] |
R7106 | T9459 | T9454 | pobj | ],by |
R7107 | T9460 | T9453 | punct | .,induced |
R7108 | T9461 | T9462 | aux | Having,shown |
R7109 | T9462 | T9474 | advcl | shown,determined |
R7110 | T9463 | T9465 | mark | that,regulated |
R7111 | T9464 | T9465 | nsubj | PKC,regulated |
R7112 | T9465 | T9462 | ccomp | regulated,shown |
R7113 | T9466 | T9467 | amod | NF-κB,activity |
R7114 | T9467 | T9465 | dobj | activity,regulated |
R7115 | T9468 | T9465 | prep | in,regulated |
R7116 | T9469 | T9470 | amod | M-CSF-stimulated,MDMs |
R7117 | T9470 | T9468 | pobj | MDMs,in |
R7118 | T9471 | T9474 | punct | ",",determined |
R7119 | T9472 | T9474 | nsubj | we,determined |
R7120 | T9473 | T9474 | advmod | next,determined |
R7121 | T9474 | T9474 | ROOT | determined,determined |
R7122 | T9475 | T9480 | mark | whether,decreased |
R7123 | T9476 | T9480 | nsubj | inhibition,decreased |
R7124 | T9477 | T9476 | prep | of,inhibition |
R7125 | T9478 | T9479 | compound | PKC,activity |
R7126 | T9479 | T9477 | pobj | activity,of |
R7127 | T9480 | T9474 | ccomp | decreased,determined |
R7128 | T9481 | T9480 | dobj | expression,decreased |
R7129 | T9482 | T9481 | prep | of,expression |
R7130 | T9483 | T9484 | amod | NF-κB-regulated,genes |
R7131 | T9484 | T9482 | pobj | genes,of |
R7132 | T9485 | T9474 | punct | .,determined |
R7133 | T9486 | T9487 | nsubj | We,treated |
R7134 | T9487 | T9487 | ROOT | treated,treated |
R7135 | T9488 | T9489 | det | both,MDMs |
R7136 | T9489 | T9487 | dobj | MDMs,treated |
R7137 | T9490 | T9489 | cc | and,MDMs |
R7138 | T9491 | T9489 | conj | RAW,MDMs |
R7139 | T9492 | T9493 | nummod | 264.7,cells |
R7140 | T9493 | T9489 | conj | cells,MDMs |
R7141 | T9494 | T9493 | prep | with,cells |
R7142 | T9495 | T9498 | det | the,Ro-31-8220 |
R7143 | T9496 | T9498 | compound | PKC,Ro-31-8220 |
R7144 | T9497 | T9498 | compound | inhibitor,Ro-31-8220 |
R7145 | T9498 | T9494 | pobj | Ro-31-8220,with |
R7146 | T9499 | T9487 | prep | for,treated |
R7147 | T9500 | T9501 | nummod | 30,minutes |
R7148 | T9501 | T9499 | pobj | minutes,for |
R7149 | T9502 | T9487 | cc | and,treated |
R7150 | T9503 | T9504 | advmod | then,stimulated |
R7151 | T9504 | T9487 | conj | stimulated,treated |
R7152 | T9505 | T9504 | prep | with,stimulated |
R7153 | T9506 | T9505 | pobj | M-CSF,with |
R7154 | T9507 | T9487 | punct | .,treated |
R7155 | T9508 | T9509 | compound | IκBα,gene |
R7156 | T9509 | T9511 | nsubjpass | gene,measured |
R7157 | T9510 | T9511 | auxpass | was,measured |
R7158 | T9511 | T9511 | ROOT | measured,measured |
R7159 | T9512 | T9511 | agent | by,measured |
R7160 | T9513 | T9512 | pobj | qRT-PCR,by |
R7161 | T9514 | T9511 | punct | .,measured |
R7162 | T9515 | T9516 | mark | As,shown |
R7163 | T9516 | T9524 | advcl | shown,enhanced |
R7164 | T9517 | T9516 | prep | in,shown |
R7165 | T9518 | T9519 | compound | Figures,6A |
R7166 | T9519 | T9517 | pobj | 6A,in |
R7167 | T9520 | T9519 | cc | and,6A |
R7168 | T9521 | T9519 | conj | 6B,6A |
R7169 | T9522 | T9521 | punct | ",",6B |
R7170 | T9523 | T9524 | nsubj | M-CSF,enhanced |
R7171 | T9524 | T9524 | ROOT | enhanced,enhanced |
R7172 | T9525 | T9527 | compound | IκBα,expression |
R7173 | T9526 | T9527 | compound | gene,expression |
R7174 | T9527 | T9524 | dobj | expression,enhanced |
R7175 | T9528 | T9527 | cc | and,expression |
R7176 | T9529 | T9530 | compound | PKC,inhibition |
R7177 | T9530 | T9527 | conj | inhibition,expression |
R7178 | T9531 | T9527 | prep | by,expression |
R7179 | T9532 | T9531 | pobj | Ro-31-8220,by |
R7180 | T9533 | T9536 | amod | decreased,expression |
R7181 | T9534 | T9536 | compound | IκBα,expression |
R7182 | T9535 | T9536 | compound | gene,expression |
R7183 | T9536 | T9527 | conj | expression,expression |
R7184 | T9537 | T9524 | prep | in,enhanced |
R7185 | T9538 | T9539 | preconj | both,MDMs |
R7186 | T9539 | T9537 | pobj | MDMs,in |
R7187 | T9540 | T9539 | cc | and,MDMs |
R7188 | T9541 | T9539 | conj | RAW,MDMs |
R7189 | T9542 | T9543 | nummod | 264.7,cells |
R7190 | T9543 | T9539 | conj | cells,MDMs |
R7191 | T9544 | T9543 | punct | (,cells |
R7192 | T9545 | T9543 | conj | p,cells |
R7193 | T9546 | T9547 | nmod | <,0.01 |
R7194 | T9547 | T9545 | npadvmod | 0.01,p |
R7195 | T9548 | T9545 | punct | ),p |
R7196 | T9549 | T9524 | punct | ",",enhanced |
R7197 | T9550 | T9524 | advcl | demonstrating,enhanced |
R7198 | T9551 | T9553 | mark | that,affected |
R7199 | T9552 | T9553 | nsubj | PKC,affected |
R7200 | T9553 | T9550 | ccomp | affected,demonstrating |
R7201 | T9554 | T9556 | amod | NF-κB-regulated,expression |
R7202 | T9555 | T9556 | compound | gene,expression |
R7203 | T9556 | T9553 | dobj | expression,affected |
R7204 | T9557 | T9553 | prep | in,affected |
R7205 | T9558 | T9557 | pobj | macrophages,in |
R7206 | T9559 | T9524 | punct | .,enhanced |
R7207 | T9560 | T9562 | aux | To,define |
R7208 | T9561 | T9562 | advmod | further,define |
R7209 | T9562 | T9578 | advcl | define,examined |
R7210 | T9563 | T9564 | det | the,role |
R7211 | T9564 | T9562 | dobj | role,define |
R7212 | T9565 | T9564 | prep | of,role |
R7213 | T9566 | T9565 | pobj | PKC,of |
R7214 | T9567 | T9564 | prep | in,role |
R7215 | T9568 | T9567 | pcomp | mediating,in |
R7216 | T9569 | T9571 | amod | human,survival |
R7217 | T9570 | T9571 | compound | MDM,survival |
R7218 | T9571 | T9568 | dobj | survival,mediating |
R7219 | T9572 | T9568 | prep | in,mediating |
R7220 | T9573 | T9572 | pobj | response,in |
R7221 | T9574 | T9573 | prep | to,response |
R7222 | T9575 | T9574 | pobj | M-CSF,to |
R7223 | T9576 | T9578 | punct | ",",examined |
R7224 | T9577 | T9578 | nsubj | we,examined |
R7225 | T9578 | T9578 | ROOT | examined,examined |
R7226 | T9579 | T9580 | det | the,expression |
R7227 | T9580 | T9578 | dobj | expression,examined |
R7228 | T9581 | T9580 | prep | of,expression |
R7229 | T9582 | T9584 | det | the,gene |
R7230 | T9583 | T9584 | compound | anti-apoptotic,gene |
R7231 | T9584 | T9581 | pobj | gene,of |
R7232 | T9585 | T9584 | appos | BCL-xL,gene |
R7233 | T9586 | T9584 | punct | ",",gene |
R7234 | T9587 | T9590 | nsubjpass | which,regulated |
R7235 | T9588 | T9590 | auxpass | is,regulated |
R7236 | T9589 | T9590 | advmod | also,regulated |
R7237 | T9590 | T9584 | relcl | regulated,gene |
R7238 | T9591 | T9590 | agent | by,regulated |
R7239 | T9592 | T9591 | pobj | NF-κB,by |
R7240 | T9593 | T9578 | punct | .,examined |
R7241 | T9594 | T9595 | mark | As,shown |
R7242 | T9595 | T9601 | advcl | shown,reduced |
R7243 | T9596 | T9595 | prep | in,shown |
R7244 | T9597 | T9598 | compound | Figure,6C |
R7245 | T9598 | T9596 | pobj | 6C,in |
R7246 | T9599 | T9601 | punct | ",",reduced |
R7247 | T9600 | T9601 | nsubj | Ro-31-8220,reduced |
R7248 | T9601 | T9601 | ROOT | reduced,reduced |
R7249 | T9602 | T9604 | nmod | M-CSF-stimulated,expression |
R7250 | T9603 | T9604 | amod | BCL-xL,expression |
R7251 | T9604 | T9601 | dobj | expression,reduced |
R7252 | T9605 | T9601 | prep | compared,reduced |
R7253 | T9606 | T9605 | prep | to,compared |
R7254 | T9607 | T9606 | pobj | cells,to |
R7255 | T9608 | T9607 | acl | treated,cells |
R7256 | T9609 | T9608 | prep | with,treated |
R7257 | T9610 | T9609 | pobj | M-CSF,with |
R7258 | T9611 | T9610 | cc | and,M-CSF |
R7259 | T9612 | T9614 | det | the,control |
R7260 | T9613 | T9614 | compound | vehicle,control |
R7261 | T9614 | T9610 | conj | control,M-CSF |
R7262 | T9615 | T9614 | appos | DMSO,control |
R7263 | T9616 | T9618 | punct | (,< |
R7264 | T9617 | T9618 | compound | p,< |
R7265 | T9618 | T9619 | compound | <,0.05 |
R7266 | T9619 | T9614 | appos | 0.05,control |
R7267 | T9620 | T9614 | punct | ),control |
R7268 | T9621 | T9601 | punct | .,reduced |
R19177 | T25121 | T25125 | nsubj | Inhibition,reduces |
R19178 | T25122 | T25121 | prep | of,Inhibition |
R19179 | T25123 | T25124 | compound | M-CSF-induced,PKC |
R19180 | T25124 | T25122 | pobj | PKC,of |
R19181 | T25125 | T25125 | ROOT | reduces,reduces |
R19182 | T25126 | T25127 | amod | NF-κB-regulated,genes |
R19183 | T25127 | T25125 | dobj | genes,reduces |
R19184 | T25128 | T25127 | prep | in,genes |
R19185 | T25129 | T25130 | preconj | both,MDMs |
R19186 | T25130 | T25128 | pobj | MDMs,in |
R19187 | T25131 | T25130 | cc | and,MDMs |
R19188 | T25132 | T25130 | conj | RAW,MDMs |
R19189 | T25133 | T25134 | nummod | 264.7,cells |
R19190 | T25134 | T25130 | conj | cells,MDMs |
R19191 | T25135 | T25125 | punct | .,reduces |
R19192 | T25136 | T25136 | ROOT | MDMs,MDMs |
R19193 | T25137 | T25138 | punct | (,A |
R19194 | T25138 | T25136 | appos | A,MDMs |
R19195 | T25139 | T25138 | cc | and,A |
R19196 | T25140 | T25148 | nmod | C,cells |
R19197 | T25141 | T25140 | punct | ),C |
R19198 | T25142 | T25140 | cc | and,C |
R19199 | T25143 | T25140 | conj | RAW,C |
R19200 | T25144 | T25143 | nummod | 264.7,RAW |
R19201 | T25145 | T25146 | punct | (,B |
R19202 | T25146 | T25143 | appos | B,RAW |
R19203 | T25147 | T25143 | punct | ),RAW |
R19204 | T25148 | T25150 | nsubjpass | cells,pretreated |
R19205 | T25149 | T25150 | auxpass | were,pretreated |
R19206 | T25150 | T25138 | conj | pretreated,A |
R19207 | T25151 | T25150 | prep | with,pretreated |
R19208 | T25152 | T25151 | pobj | Ro-31-8220,with |
R19209 | T25153 | T25152 | cc | or,Ro-31-8220 |
R19210 | T25154 | T25155 | amod | solvent,control |
R19211 | T25155 | T25156 | compound | control,DMSO |
R19212 | T25156 | T25152 | conj | DMSO,Ro-31-8220 |
R19213 | T25157 | T25150 | prep | for,pretreated |
R19214 | T25158 | T25159 | nummod | 30,minutes |
R19215 | T25159 | T25157 | pobj | minutes,for |
R19216 | T25160 | T25150 | advmod | prior,pretreated |
R19217 | T25161 | T25160 | prep | to,prior |
R19218 | T25162 | T25163 | compound | M-CSF,stimulation |
R19219 | T25163 | T25161 | pobj | stimulation,to |
R19220 | T25164 | T25160 | prep | for,prior |
R19221 | T25165 | T25167 | det | the,times |
R19222 | T25166 | T25167 | amod | indicated,times |
R19223 | T25167 | T25164 | pobj | times,for |
R19224 | T25168 | T25150 | punct | .,pretreated |
R19225 | T25169 | T25170 | amod | Total,RNA |
R19226 | T25170 | T25171 | nsubj | RNA,was |
R19227 | T25171 | T25171 | ROOT | was,was |
R19228 | T25172 | T25171 | acomp | isolated,was |
R19229 | T25173 | T25172 | cc | and,isolated |
R19230 | T25174 | T25172 | conj | converted,isolated |
R19231 | T25175 | T25174 | prep | to,converted |
R19232 | T25176 | T25175 | pobj | cDNA,to |
R19233 | T25177 | T25171 | punct | .,was |
R19234 | T25178 | T25180 | amod | Real-time,PCR |
R19235 | T25179 | T25180 | compound | RT,PCR |
R19236 | T25180 | T25182 | nsubjpass | PCR,performed |
R19237 | T25181 | T25182 | auxpass | was,performed |
R19238 | T25182 | T25182 | ROOT | performed,performed |
R19239 | T25183 | T25182 | advcl | using,performed |
R19240 | T25184 | T25183 | dobj | primers,using |
R19241 | T25185 | T25183 | prep | for,using |
R19242 | T25186 | T25185 | pobj | IκBα,for |
R19243 | T25187 | T25186 | punct | ",",IκBα |
R19244 | T25188 | T25186 | conj | BCL-xl,IκBα |
R19245 | T25189 | T25188 | cc | or,BCL-xl |
R19246 | T25190 | T25188 | conj | GAPDH,BCL-xl |
R19247 | T25191 | T25182 | punct | .,performed |
R19248 | T25192 | T25194 | nsubjpass | Data,expressed |
R19249 | T25193 | T25194 | auxpass | are,expressed |
R19250 | T25194 | T25194 | ROOT | expressed,expressed |
R19251 | T25195 | T25194 | prep | as,expressed |
R19252 | T25196 | T25197 | amod | relative,fold |
R19253 | T25197 | T25198 | compound | fold,increase |
R19254 | T25198 | T25195 | pobj | increase,as |
R19255 | T25199 | T25198 | prep | of,increase |
R19256 | T25200 | T25199 | pobj | IκBα,of |
R19257 | T25201 | T25200 | cc | or,IκBα |
R19258 | T25202 | T25200 | conj | BCL-xl,IκBα |
R19259 | T25203 | T25204 | compound | gene,expression |
R19260 | T25204 | T25198 | conj | expression,increase |
R19261 | T25205 | T25204 | prep | upon,expression |
R19262 | T25206 | T25205 | pobj | treatment,upon |
R19263 | T25207 | T25204 | prep | over,expression |
R19264 | T25208 | T25209 | amod | non-stimulated,cells |
R19265 | T25209 | T25207 | pobj | cells,over |
R19266 | T25210 | T25194 | punct | .,expressed |
R19267 | T25211 | T25212 | nsubj | Data,represent |
R19268 | T25212 | T25212 | ROOT | represent,represent |
R19269 | T25213 | T25216 | det | the,S.E.M |
R19270 | T25214 | T25216 | amod | mean,S.E.M |
R19271 | T25215 | T25216 | compound | ±,S.E.M |
R19272 | T25216 | T25212 | dobj | S.E.M,represent |
R19273 | T25217 | T25212 | prep | for,represent |
R19274 | T25218 | T25220 | nummod | three,experiments |
R19275 | T25219 | T25220 | amod | independent,experiments |
R19276 | T25220 | T25217 | pobj | experiments,for |
R19277 | T25221 | T25212 | punct | .,represent |
test2
Id | Subject | Object | Predicate | Lexical cue | Speculation |
---|---|---|---|---|---|
T9395 | 0-5 | Protein | denotes | M-CSF | |
T9396 | 146-150 | Protein | denotes | IκBα | |
T9397 | 161-168 | Positive_regulation | denotes | induced | |
T9398 | 245-250 | Protein | denotes | M-CSF | |
T9399 | 484-489 | Protein | denotes | M-CSF | |
T9400 | 491-495 | Protein | denotes | IκBα | true |
T9401 | 557-562 | Protein | denotes | M-CSF | |
T9402 | 563-571 | Positive_regulation | denotes | enhanced | |
T9403 | 572-576 | Protein | denotes | IκBα | |
T9404 | 582-592 | Gene_expression | denotes | expression | |
T9405 | 626-635 | Negative_regulation | denotes | decreased | |
T9406 | 636-640 | Protein | denotes | IκBα | |
T9407 | 646-656 | Gene_expression | denotes | expression | |
T9408 | 1471-1476 | Protein | denotes | M-CSF | |
T9409 | 1494-1504 | Gene_expression | denotes | expression | |
T9410 | 1532-1538 | Protein | denotes | BCL-xL | |
T9411 | 1554-1563 | Regulation | denotes | regulated | |
T9412 | 1608-1615 | Negative_regulation | denotes | reduced | |
T9413 | 1616-1621 | Protein | denotes | M-CSF | |
T9414 | 1622-1632 | Positive_regulation | denotes | stimulated | |
T9415 | 1633-1639 | Protein | denotes | BCL-xL | |
T9416 | 1640-1650 | Gene_expression | denotes | expression | |
T9417 | 1682-1687 | Protein | denotes | M-CSF | |
T25107 | 838-843 | Protein | denotes | M-CSF | |
T25108 | 1039-1044 | Protein | denotes | M-CSF | |
T25109 | 1177-1181 | Protein | denotes | IκBα | |
T25110 | 1183-1189 | Protein | denotes | BCL-xl | |
T25111 | 1236-1244 | Positive_regulation | denotes | increase | |
T25112 | 1248-1252 | Protein | denotes | IκBα | |
T25113 | 1256-1262 | Protein | denotes | BCL-xl | |
T25114 | 1268-1278 | Gene_expression | denotes | expression | |
R7062 | T9396 | T9397 | themeOf | IκBα,induced | |
R7063 | T9401 | T9402 | causeOf | M-CSF,enhanced | |
R7064 | T9403 | T9404 | themeOf | IκBα,expression | |
R7065 | T9404 | T9402 | themeOf | expression,enhanced | |
R7066 | T9406 | T9407 | themeOf | IκBα,expression | |
R7067 | T9407 | T9405 | themeOf | expression,decreased | |
R7068 | T9409 | T9411 | themeOf | expression,regulated | |
R7069 | T9410 | T9409 | themeOf | BCL-xL,expression | |
R7070 | T9413 | T9414 | causeOf | M-CSF,stimulated | |
R7071 | T9414 | T9412 | themeOf | stimulated,reduced | |
R7072 | T9415 | T9416 | themeOf | BCL-xL,expression | |
R7073 | T9416 | T9414 | themeOf | expression,stimulated | |
R19174 | T25112 | T25114 | themeOf | IκBα,expression | |
R19175 | T25113 | T25114 | themeOf | BCL-xl,expression | |
R19176 | T25114 | T25111 | themeOf | expression,increase |