PMC:3245220 / 15646-17455
Annnotations
bionlp-st-ge-2016-uniprot
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T7333 | 0-5 | P09603 | denotes | M-CSF |
| T7334 | 2-5 | P04141 | denotes | CSF |
| T7335 | 14-18 | P17252 | denotes | PKCα |
| T7336 | 132-137 | P09603 | denotes | M-CSF |
| T7337 | 134-137 | P04141 | denotes | CSF |
| T7338 | 219-223 | P17252 | denotes | PKCα |
| T7339 | 251-256 | P09603 | denotes | M-CSF |
| T7340 | 253-256 | P04141 | denotes | CSF |
| T7341 | 272-276 | P17252 | denotes | PKCα |
| T7342 | 691-696 | P09603 | denotes | M-CSF |
| T7343 | 693-696 | P04141 | denotes | CSF |
| T7344 | 849-853 | P17252 | denotes | PKCα |
| T7345 | 889-893 | P17252 | denotes | PKCα |
| T24373 | 977-982 | P09603 | denotes | M-CSF |
| T24374 | 979-982 | P04141 | denotes | CSF |
| T24375 | 993-997 | P17252 | denotes | PKCα |
| T24376 | 1031-1036 | P09603 | denotes | M-CSF |
| T24377 | 1033-1036 | P04141 | denotes | CSF |
| T24378 | 1406-1410 | P17252 | denotes | PKCα |
| T24379 | 1600-1604 | P17252 | denotes | PKCα |
| T24380 | 1652-1657 | P09603 | denotes | M-CSF |
| T24381 | 1654-1657 | P04141 | denotes | CSF |
| T24382 | 1751-1756 | P09603 | denotes | M-CSF |
| T24383 | 1753-1756 | P04141 | denotes | CSF |
bionlp-st-ge-2016-reference
| Id | Subject | Object | Predicate | Lexical cue | Speculation |
|---|---|---|---|---|---|
| T7346 | 230-247 | Regulation | denotes | downstream target | true |
| T7347 | 14-18 | Protein | denotes | PKCα | |
| T7348 | 219-223 | Protein | denotes | PKCα | |
| T7349 | 0-5 | Protein | denotes | M-CSF | |
| T7350 | 132-137 | Protein | denotes | M-CSF | |
| T7351 | 251-256 | Protein | denotes | M-CSF | |
| T7352 | 691-696 | Protein | denotes | M-CSF | |
| T24384 | 983-992 | Positive_regulation | denotes | activates | |
| T24385 | 993-997 | Protein | denotes | PKCα | |
| T24386 | 1406-1410 | Protein | denotes | PKCα | |
| T24387 | 1600-1604 | Protein | denotes | PKCα | |
| T24388 | 977-982 | Protein | denotes | M-CSF | |
| T24389 | 1031-1036 | Protein | denotes | M-CSF | |
| T24390 | 1652-1657 | Protein | denotes | M-CSF | |
| T24391 | 1751-1756 | Protein | denotes | M-CSF | |
| R5490 | T7348 | T7346 | themeOf | PKCα,downstream target | |
| R5491 | T7351 | T7346 | causeOf | M-CSF,downstream target | |
| R18644 | T24385 | T24384 | themeOf | PKCα,activates | |
| R18645 | T24388 | T24384 | causeOf | M-CSF,activates |
bionlp-st-ge-2016-reference-tees
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T7418 | 14-25 | Protein | denotes | PKCα Kinase |
| T7419 | 78-82 | Protein | denotes | PKCs |
| T7420 | 111-116 | Protein | denotes | NF-κB |
| T7421 | 132-137 | Protein | denotes | M-CSF |
| T7422 | 214-217 | Protein | denotes | PKC |
| T7423 | 219-223 | Protein | denotes | PKCα |
| T7424 | 251-256 | Protein | denotes | M-CSF |
| T7425 | 100-110 | Positive_regulation | denotes | activating |
| T7426 | 241-247 | Positive_regulation | denotes | target |
| T7427 | 272-276 | Protein | denotes | PKCα |
| T7428 | 368-378 | Protein | denotes | PKC kinase |
| T7429 | 744-747 | Protein | denotes | IgG |
| T7430 | 828-853 | Protein | denotes | antibody recognizing PKCα |
| T7431 | 889-893 | Protein | denotes | PKCα |
| T24459 | 977-982 | Protein | denotes | M-CSF |
| T24460 | 993-997 | Protein | denotes | PKCα |
| T24461 | 983-992 | Positive_regulation | denotes | activates |
| T24462 | 1031-1036 | Protein | denotes | M-CSF |
| T24463 | 1117-1134 | Protein | denotes | anti-PKC antibody |
| T24464 | 1138-1158 | Protein | denotes | control IgG antibody |
| T24465 | 1204-1214 | Protein | denotes | PKC kinase |
| T24466 | 1406-1410 | Protein | denotes | PKCα |
| T24467 | 1534-1537 | Protein | denotes | Rad |
| T24468 | 1600-1604 | Protein | denotes | PKCα |
| T24469 | 1652-1657 | Protein | denotes | M-CSF |
| T24470 | 1751-1756 | Protein | denotes | M-CSF |
| R5506 | T7420 | T7425 | themeOf | NF-κB,activating |
| R5507 | T7423 | T7426 | causeOf | PKCα,target |
| R5508 | T7424 | T7426 | themeOf | M-CSF,target |
| R18658 | T24459 | T24461 | causeOf | M-CSF,activates |
| R18659 | T24460 | T24461 | themeOf | PKCα,activates |
events-check-again
| Id | Subject | Object | Predicate | Lexical cue | Speculation |
|---|---|---|---|---|---|
| T7411 | 0-5 | Protein | denotes | M-CSF | |
| T7412 | 14-18 | Protein | denotes | PKCα | |
| T7413 | 132-137 | Protein | denotes | M-CSF | |
| T7414 | 219-223 | Protein | denotes | PKCα | |
| T7415 | 230-247 | Regulation | denotes | downstream target | true |
| T7416 | 251-256 | Protein | denotes | M-CSF | |
| T7417 | 691-696 | Protein | denotes | M-CSF | |
| T24451 | 977-982 | Protein | denotes | M-CSF | |
| T24452 | 983-992 | Positive_regulation | denotes | activates | |
| T24453 | 993-997 | Protein | denotes | PKCα | |
| T24454 | 1031-1036 | Protein | denotes | M-CSF | |
| T24455 | 1406-1410 | Protein | denotes | PKCα | |
| T24456 | 1600-1604 | Protein | denotes | PKCα | |
| T24457 | 1652-1657 | Protein | denotes | M-CSF | |
| T24458 | 1751-1756 | Protein | denotes | M-CSF | |
| R5504 | T7414 | T7415 | themeOf | PKCα,downstream target | |
| R5505 | T7416 | T7415 | causeOf | M-CSF,downstream target | |
| R18656 | T24451 | T24452 | causeOf | M-CSF,activates | |
| R18657 | T24453 | T24452 | themeOf | PKCα,activates |
GO-CC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T7368 | 593-598 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T7369 | 732-742 | http://purl.obolibrary.org/obo/GO_0019815 | denotes | antibodies |
| T7370 | 828-836 | http://purl.obolibrary.org/obo/GO_0019815 | denotes | antibody |
| T7371 | 732-742 | http://purl.obolibrary.org/obo/GO_0042571 | denotes | antibodies |
| T7372 | 828-836 | http://purl.obolibrary.org/obo/GO_0042571 | denotes | antibody |
| T24405 | 1126-1134 | http://purl.obolibrary.org/obo/GO_0019815 | denotes | antibody |
| T24406 | 1150-1158 | http://purl.obolibrary.org/obo/GO_0019815 | denotes | antibody |
| T24407 | 1126-1134 | http://purl.obolibrary.org/obo/GO_0042571 | denotes | antibody |
| T24408 | 1150-1158 | http://purl.obolibrary.org/obo/GO_0042571 | denotes | antibody |
| T24409 | 1146-1158 | http://purl.obolibrary.org/obo/GO_0071736 | denotes | IgG antibody |
GO-MF
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T7359 | 14-18 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCα |
| T7360 | 219-223 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCα |
| T7361 | 272-276 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCα |
| T7362 | 849-853 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCα |
| T7363 | 214-217 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
| T7364 | 368-371 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
| T7365 | 19-34 | http://purl.obolibrary.org/obo/GO_0016301 | denotes | Kinase Activity |
| T7366 | 732-742 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibodies |
| T7367 | 828-836 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibody |
| T24398 | 993-997 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCα |
| T24399 | 1406-1410 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCα |
| T24400 | 1122-1125 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
| T24401 | 1204-1207 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
| T24402 | 1126-1134 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibody |
| T24403 | 1150-1158 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibody |
| T24404 | 1208-1223 | http://purl.obolibrary.org/obo/GO_0016301 | denotes | kinase activity |
GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T7432 | 120-137 | http://purl.obolibrary.org/obo/GO_0036005 | denotes | response to M-CSF |
| T7433 | 120-137 | http://purl.obolibrary.org/obo/GO_1903970 | denotes | response to M-CSF |
| T7434 | 120-137 | http://purl.obolibrary.org/obo/GO_1903971 | denotes | response to M-CSF |
| T7435 | 19-34 | http://purl.obolibrary.org/obo/GO_0016301 | denotes | Kinase Activity |
| T7436 | 100-116 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | activating NF-κB |
| T7437 | 120-137 | http://purl.obolibrary.org/obo/GO_1903969 | denotes | response to M-CSF |
| T24471 | 977-992 | http://purl.obolibrary.org/obo/GO_1901258 | denotes | M-CSF activates |
| T24472 | 977-992 | http://purl.obolibrary.org/obo/GO_1903971 | denotes | M-CSF activates |
| T24473 | 1208-1223 | http://purl.obolibrary.org/obo/GO_0016301 | denotes | kinase activity |
pmc-enju-pas
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T7176 | 0-13 | VB | denotes | M-CSF-Induces |
| T7177 | 14-18 | NNP | denotes | PKCα |
| T7178 | 19-25 | NNP | denotes | Kinase |
| T7179 | 26-34 | NN | denotes | Activity |
| T7180 | 35-40 | IN | denotes | Since |
| T7181 | 41-44 | PRP-DOLLAR- | denotes | our |
| T7182 | 45-49 | NN | denotes | data |
| T7183 | 50-59 | VB | denotes | suggested |
| T7184 | 60-64 | IN | denotes | that |
| T7185 | 65-77 | JJ | denotes | conventional |
| T7186 | 78-82 | NN | denotes | PKCs |
| T7187 | 83-87 | VB | denotes | were |
| T7188 | 88-96 | VB | denotes | involved |
| T7189 | 97-99 | IN | denotes | in |
| T7190 | 100-110 | VB | denotes | activating |
| T7191 | 111-116 | NN | denotes | NF-κB |
| T7192 | 117-119 | IN | denotes | in |
| T7193 | 120-128 | NN | denotes | response |
| T7194 | 129-131 | TO | denotes | to |
| T7195 | 132-137 | NN | denotes | M-CSF |
| T7196 | 138-140 | IN | denotes | in |
| T7197 | 141-148 | JJ | denotes | primary |
| T7198 | 149-154 | JJ | denotes | human |
| T7199 | 155-166 | NN | denotes | macrophages |
| T7200 | 166-167 | -COMMA- | denotes | , |
| T7201 | 168-170 | PRP | denotes | we |
| T7202 | 171-175 | RB | denotes | next |
| T7203 | 176-188 | VB | denotes | investigated |
| T7204 | 189-196 | IN | denotes | whether |
| T7205 | 197-200 | DT | denotes | the |
| T7206 | 201-213 | JJ | denotes | conventional |
| T7207 | 214-217 | NN | denotes | PKC |
| T7208 | 217-218 | -COMMA- | denotes | , |
| T7209 | 219-223 | NN | denotes | PKCα |
| T7210 | 224-227 | VB | denotes | was |
| T7211 | 228-229 | DT | denotes | a |
| T7212 | 230-240 | JJ | denotes | downstream |
| T7213 | 241-247 | NN | denotes | target |
| T7214 | 248-250 | IN | denotes | of |
| T7215 | 251-256 | NN | denotes | M-CSF |
| T7216 | 257-259 | IN | denotes | in |
| T7217 | 260-265 | JJ | denotes | human |
| T7218 | 266-270 | NN | denotes | MDMs |
| T7219 | 272-276 | NN | denotes | PKCα |
| T7220 | 277-280 | VB | denotes | was |
| T7221 | 281-299 | VB | denotes | immunoprecipitated |
| T7222 | 300-304 | IN | denotes | from |
| T7223 | 305-310 | JJ | denotes | human |
| T7224 | 311-315 | NN | denotes | MDMs |
| T7225 | 316-318 | IN | denotes | at |
| T7226 | 319-322 | DT | denotes | the |
| T7227 | 323-332 | VB | denotes | indicated |
| T7228 | 333-337 | NN | denotes | time |
| T7229 | 338-344 | NN | denotes | points |
| T7230 | 345-346 | -LRB- | denotes | ( |
| T7231 | 346-352 | NN | denotes | Figure |
| T7232 | 353-354 | CD | denotes | 4 |
| T7233 | 354-355 | -RRB- | denotes | ) |
| T7234 | 355-356 | -COMMA- | denotes | , |
| T7235 | 357-360 | CC | denotes | and |
| T7236 | 361-365 | RB | denotes | then |
| T7237 | 366-367 | DT | denotes | a |
| T7238 | 368-371 | NN | denotes | PKC |
| T7239 | 372-378 | NN | denotes | kinase |
| T7240 | 379-384 | NN | denotes | assay |
| T7241 | 385-388 | VB | denotes | was |
| T7242 | 389-398 | VB | denotes | performed |
| T7243 | 399-404 | VB | denotes | using |
| T7244 | 405-406 | DT | denotes | a |
| T7245 | 407-425 | JJ | denotes | fluorescein-tagged |
| T7246 | 426-433 | NN | denotes | peptide |
| T7247 | 434-436 | IN | denotes | as |
| T7248 | 437-438 | DT | denotes | a |
| T7249 | 439-448 | NN | denotes | substrate |
| T7250 | 450-452 | IN | denotes | As |
| T7251 | 453-458 | VB | denotes | shown |
| T7252 | 459-461 | IN | denotes | in |
| T7253 | 462-468 | NN | denotes | Figure |
| T7254 | 469-470 | CD | denotes | 4 |
| T7255 | 471-472 | -LRB- | denotes | ( |
| T7256 | 472-477 | JJ | denotes | upper |
| T7257 | 478-483 | NN | denotes | panel |
| T7258 | 483-484 | -RRB- | denotes | ) |
| T7259 | 484-485 | -COMMA- | denotes | , |
| T7260 | 486-489 | DT | denotes | the |
| T7261 | 490-497 | NN | denotes | peptide |
| T7262 | 498-507 | NN | denotes | substrate |
| T7263 | 508-511 | VB | denotes | was |
| T7264 | 512-521 | RB | denotes | maximally |
| T7265 | 522-536 | VB | denotes | phosphorylated |
| T7266 | 537-543 | IN | denotes | within |
| T7267 | 544-546 | CD | denotes | 10 |
| T7268 | 547-554 | NN | denotes | minutes |
| T7269 | 555-557 | IN | denotes | of |
| T7270 | 558-569 | NN | denotes | stimulation |
| T7271 | 570-571 | -LRB- | denotes | ( |
| T7272 | 571-579 | RB | denotes | 1.8-fold |
| T7273 | 580-584 | IN | denotes | over |
| T7274 | 585-592 | VB | denotes | resting |
| T7275 | 593-598 | NN | denotes | cells |
| T7276 | 598-599 | -COMMA- | denotes | , |
| T7277 | 600-605 | JJ | denotes | lower |
| T7278 | 606-611 | NN | denotes | panel |
| T7279 | 611-612 | -RRB- | denotes | ) |
| T7280 | 612-613 | -COMMA- | denotes | , |
| T7281 | 614-617 | CC | denotes | and |
| T7282 | 618-622 | RB | denotes | then |
| T7283 | 623-631 | VB | denotes | returned |
| T7284 | 632-634 | TO | denotes | to |
| T7285 | 635-640 | JJ | denotes | basal |
| T7286 | 641-647 | NN | denotes | levels |
| T7287 | 648-650 | IN | denotes | by |
| T7288 | 651-653 | CD | denotes | 15 |
| T7289 | 654-661 | NN | denotes | minutes |
| T7290 | 663-667 | DT | denotes | This |
| T7291 | 668-674 | NN | denotes | effect |
| T7292 | 675-678 | VB | denotes | was |
| T7293 | 679-682 | RB | denotes | not |
| T7294 | 683-687 | VB | denotes | seen |
| T7295 | 688-690 | IN | denotes | in |
| T7296 | 691-707 | JJ | denotes | M-CSF-stimulated |
| T7297 | 708-717 | NN | denotes | monocytes |
| T7298 | 718-722 | WRB | denotes | when |
| T7299 | 723-731 | JJ | denotes | isogenic |
| T7300 | 732-742 | NN | denotes | antibodies |
| T7301 | 743-744 | -LRB- | denotes | ( |
| T7302 | 744-747 | NN | denotes | IgG |
| T7303 | 747-748 | -RRB- | denotes | ) |
| T7304 | 749-753 | VB | denotes | were |
| T7305 | 754-758 | VB | denotes | used |
| T7306 | 759-762 | IN | denotes | for |
| T7307 | 763-782 | NN | denotes | immunoprecipitation |
| T7308 | 784-791 | JJ | denotes | Western |
| T7309 | 792-797 | NN | denotes | blots |
| T7310 | 798-800 | IN | denotes | of |
| T7311 | 801-810 | JJ | denotes | identical |
| T7312 | 811-818 | NN | denotes | samples |
| T7313 | 819-824 | VB | denotes | using |
| T7314 | 825-827 | DT | denotes | an |
| T7315 | 828-836 | NN | denotes | antibody |
| T7316 | 837-848 | VB | denotes | recognizing |
| T7317 | 849-853 | NN | denotes | PKCα |
| T7318 | 854-866 | VB | denotes | demonstrated |
| T7319 | 867-871 | IN | denotes | that |
| T7320 | 872-877 | JJ | denotes | equal |
| T7321 | 878-885 | NN | denotes | amounts |
| T7322 | 886-888 | IN | denotes | of |
| T7323 | 889-893 | NN | denotes | PKCα |
| T7324 | 894-898 | VB | denotes | were |
| T7325 | 899-906 | VB | denotes | assayed |
| T7326 | 907-908 | -LRB- | denotes | ( |
| T7327 | 908-914 | NN | denotes | Figure |
| T7328 | 915-916 | CD | denotes | 4 |
| T7329 | 916-917 | -COMMA- | denotes | , |
| T7330 | 918-924 | JJ | denotes | middle |
| T7331 | 925-930 | NN | denotes | panel |
| T7332 | 930-931 | -RRB- | denotes | ) |
| T24238 | 977-982 | NN | denotes | M-CSF |
| T24239 | 983-992 | VB | denotes | activates |
| T24240 | 993-997 | NN | denotes | PKCα |
| T24241 | 998-1000 | IN | denotes | in |
| T24242 | 1001-1006 | JJ | denotes | human |
| T24243 | 1007-1011 | NN | denotes | MDMs |
| T24244 | 1013-1017 | NN | denotes | MDMs |
| T24245 | 1018-1025 | VB | denotes | treated |
| T24246 | 1026-1030 | IN | denotes | with |
| T24247 | 1031-1036 | NN | denotes | M-CSF |
| T24248 | 1037-1038 | -LRB- | denotes | ( |
| T24249 | 1038-1041 | CD | denotes | 100 |
| T24250 | 1042-1047 | NN | denotes | ng/ml |
| T24251 | 1047-1048 | -RRB- | denotes | ) |
| T24252 | 1049-1052 | IN | denotes | for |
| T24253 | 1053-1060 | VB | denotes | varying |
| T24254 | 1061-1068 | NN | denotes | amounts |
| T24255 | 1069-1071 | IN | denotes | of |
| T24256 | 1072-1076 | NN | denotes | time |
| T24257 | 1077-1081 | VB | denotes | were |
| T24258 | 1082-1087 | VB | denotes | lysed |
| T24259 | 1088-1091 | CC | denotes | and |
| T24260 | 1092-1110 | VB | denotes | immunoprecipitated |
| T24261 | 1111-1116 | VB | denotes | using |
| T24262 | 1117-1125 | JJ | denotes | anti-PKC |
| T24263 | 1126-1134 | NN | denotes | antibody |
| T24264 | 1135-1137 | CC | denotes | or |
| T24265 | 1138-1145 | NN | denotes | control |
| T24266 | 1146-1149 | NN | denotes | IgG |
| T24267 | 1150-1158 | NN | denotes | antibody |
| T24268 | 1160-1163 | CD | denotes | One |
| T24269 | 1164-1168 | NN | denotes | half |
| T24270 | 1169-1171 | IN | denotes | of |
| T24271 | 1172-1175 | DT | denotes | the |
| T24272 | 1176-1183 | NN | denotes | samples |
| T24273 | 1184-1187 | VB | denotes | was |
| T24274 | 1188-1192 | VB | denotes | used |
| T24275 | 1193-1195 | TO | denotes | to |
| T24276 | 1196-1203 | VB | denotes | analyze |
| T24277 | 1204-1207 | NN | denotes | PKC |
| T24278 | 1208-1214 | NN | denotes | kinase |
| T24279 | 1215-1223 | NN | denotes | activity |
| T24280 | 1224-1229 | VB | denotes | using |
| T24281 | 1230-1231 | DT | denotes | a |
| T24282 | 1232-1243 | NN | denotes | fluorescein |
| T24283 | 1244-1250 | VB | denotes | tagged |
| T24284 | 1251-1258 | NN | denotes | peptide |
| T24285 | 1259-1262 | CC | denotes | and |
| T24286 | 1263-1273 | VB | denotes | visualized |
| T24287 | 1274-1276 | IN | denotes | by |
| T24288 | 1277-1284 | NN | denotes | agarose |
| T24289 | 1285-1288 | NN | denotes | gel |
| T24290 | 1289-1304 | NN | denotes | electrophoresis |
| T24291 | 1305-1306 | -LRB- | denotes | ( |
| T24292 | 1306-1309 | JJ | denotes | top |
| T24293 | 1310-1315 | NN | denotes | panel |
| T24294 | 1315-1316 | -RRB- | denotes | ) |
| T24295 | 1316-1317 | -COMMA- | denotes | , |
| T24296 | 1318-1323 | IN | denotes | while |
| T24297 | 1324-1327 | DT | denotes | the |
| T24298 | 1328-1333 | JJ | denotes | other |
| T24299 | 1334-1338 | NN | denotes | half |
| T24300 | 1339-1342 | VB | denotes | was |
| T24301 | 1343-1352 | VB | denotes | subjected |
| T24302 | 1353-1355 | TO | denotes | to |
| T24303 | 1356-1363 | JJ | denotes | Western |
| T24304 | 1364-1368 | NN | denotes | blot |
| T24305 | 1369-1377 | NN | denotes | analysis |
| T24306 | 1378-1380 | TO | denotes | to |
| T24307 | 1381-1388 | VB | denotes | confirm |
| T24308 | 1389-1394 | JJ | denotes | equal |
| T24309 | 1395-1402 | NN | denotes | amounts |
| T24310 | 1403-1405 | IN | denotes | of |
| T24311 | 1406-1410 | NN | denotes | PKCα |
| T24312 | 1411-1415 | VB | denotes | were |
| T24313 | 1416-1434 | VB | denotes | immunoprecipitated |
| T24314 | 1435-1439 | IN | denotes | from |
| T24315 | 1440-1444 | DT | denotes | each |
| T24316 | 1445-1451 | NN | denotes | sample |
| T24317 | 1452-1453 | -LRB- | denotes | ( |
| T24318 | 1453-1459 | JJ | denotes | middle |
| T24319 | 1460-1465 | NN | denotes | panel |
| T24320 | 1465-1466 | -RRB- | denotes | ) |
| T24321 | 1468-1471 | DT | denotes | The |
| T24322 | 1472-1478 | NN | denotes | kinase |
| T24323 | 1479-1484 | NN | denotes | assay |
| T24324 | 1485-1488 | VB | denotes | was |
| T24325 | 1489-1500 | VB | denotes | quantitated |
| T24326 | 1501-1506 | VB | denotes | using |
| T24327 | 1507-1515 | NN | denotes | Quantity |
| T24328 | 1516-1519 | CD | denotes | One |
| T24329 | 1520-1528 | NN | denotes | software |
| T24330 | 1529-1530 | -LRB- | denotes | ( |
| T24331 | 1530-1537 | NN | denotes | Bio-Rad |
| T24332 | 1537-1538 | -RRB- | denotes | ) |
| T24333 | 1539-1540 | -LRB- | denotes | ( |
| T24334 | 1540-1546 | JJ | denotes | bottom |
| T24335 | 1547-1552 | NN | denotes | panel |
| T24336 | 1552-1553 | -RRB- | denotes | ) |
| T24337 | 1555-1559 | NN | denotes | Data |
| T24338 | 1560-1570 | VB | denotes | represents |
| T24339 | 1571-1574 | DT | denotes | the |
| T24340 | 1575-1582 | JJ | denotes | average |
| T24341 | 1583-1587 | JJ | denotes | fold |
| T24342 | 1588-1596 | NN | denotes | increase |
| T24343 | 1597-1599 | IN | denotes | of |
| T24344 | 1600-1604 | NN | denotes | PKCα |
| T24345 | 1605-1613 | NN | denotes | activity |
| T24346 | 1614-1616 | IN | denotes | in |
| T24347 | 1617-1631 | JJ | denotes | non-stimulated |
| T24348 | 1632-1639 | NN | denotes | samples |
| T24349 | 1640-1648 | VB | denotes | compared |
| T24350 | 1649-1651 | TO | denotes | to |
| T24351 | 1652-1665 | JJ | denotes | M-CSF-treated |
| T24352 | 1666-1669 | NN | denotes | MDM |
| T24353 | 1670-1671 | NN | denotes | ± |
| T24354 | 1672-1677 | NN | denotes | S.E.M |
| T24355 | 1678-1681 | IN | denotes | for |
| T24356 | 1682-1687 | CD | denotes | three |
| T24357 | 1688-1699 | JJ | denotes | independent |
| T24358 | 1700-1711 | NN | denotes | experiments |
| T24359 | 1713-1715 | NN | denotes | NS |
| T24360 | 1715-1716 | -COLON- | denotes | : |
| T24361 | 1717-1732 | JJ | denotes | non-stimulated. |
| T24362 | 1733-1734 | SYM | denotes | * |
| T24363 | 1735-1738 | DT | denotes | The |
| T24364 | 1739-1747 | NN | denotes | p-values |
| T24365 | 1748-1750 | IN | denotes | of |
| T24366 | 1751-1756 | NN | denotes | M-CSF |
| T24367 | 1757-1767 | VB | denotes | stimulated |
| T24368 | 1768-1776 | VB | denotes | compared |
| T24369 | 1777-1779 | TO | denotes | to |
| T24370 | 1780-1794 | JJ | denotes | non-stimulated |
| T24371 | 1795-1799 | VB | denotes | were |
| T24372 | 1800-1805 | CD | denotes | ≤0.05 |
| R5331 | T7178 | T7177 | arg1Of | Kinase,PKCα |
| R5332 | T7179 | T7176 | arg1Of | Activity,M-CSF-Induces |
| R5333 | T7179 | T7178 | arg1Of | Activity,Kinase |
| R5334 | T7182 | T7181 | arg1Of | data,our |
| R5335 | T7182 | T7183 | arg1Of | data,suggested |
| R5336 | T7183 | T7180 | arg2Of | suggested,Since |
| R5337 | T7186 | T7185 | arg1Of | PKCs,conventional |
| R5338 | T7186 | T7187 | arg1Of | PKCs,were |
| R5339 | T7186 | T7188 | arg2Of | PKCs,involved |
| R5340 | T7188 | T7183 | arg2Of | involved,suggested |
| R5341 | T7188 | T7184 | arg1Of | involved,that |
| R5342 | T7188 | T7187 | arg2Of | involved,were |
| R5343 | T7188 | T7189 | arg1Of | involved,in |
| R5344 | T7190 | T7189 | arg2Of | activating,in |
| R5345 | T7190 | T7192 | arg1Of | activating,in |
| R5346 | T7191 | T7190 | arg2Of | NF-κB,activating |
| R5347 | T7193 | T7192 | arg2Of | response,in |
| R5348 | T7193 | T7194 | arg1Of | response,to |
| R5349 | T7195 | T7194 | arg2Of | M-CSF,to |
| R5350 | T7195 | T7196 | arg1Of | M-CSF,in |
| R5351 | T7199 | T7196 | arg2Of | macrophages,in |
| R5352 | T7199 | T7197 | arg1Of | macrophages,primary |
| R5353 | T7199 | T7198 | arg1Of | macrophages,human |
| R5354 | T7201 | T7203 | arg1Of | we,investigated |
| R5355 | T7203 | T7180 | arg1Of | investigated,Since |
| R5356 | T7203 | T7200 | arg1Of | investigated,"," |
| R5357 | T7203 | T7202 | arg1Of | investigated,next |
| R5358 | T7207 | T7205 | arg1Of | PKC,the |
| R5359 | T7207 | T7206 | arg1Of | PKC,conventional |
| R5360 | T7207 | T7208 | arg1Of | PKC,"," |
| R5361 | T7207 | T7210 | arg1Of | PKC,was |
| R5362 | T7209 | T7208 | arg2Of | PKCα,"," |
| R5363 | T7210 | T7203 | arg2Of | was,investigated |
| R5364 | T7210 | T7204 | arg1Of | was,whether |
| R5365 | T7213 | T7210 | arg2Of | target,was |
| R5366 | T7213 | T7211 | arg1Of | target,a |
| R5367 | T7213 | T7212 | arg1Of | target,downstream |
| R5368 | T7213 | T7214 | arg1Of | target,of |
| R5369 | T7213 | T7216 | arg1Of | target,in |
| R5370 | T7215 | T7214 | arg2Of | M-CSF,of |
| R5371 | T7218 | T7216 | arg2Of | MDMs,in |
| R5372 | T7218 | T7217 | arg1Of | MDMs,human |
| R5373 | T7219 | T7220 | arg1Of | PKCα,was |
| R5374 | T7219 | T7221 | arg2Of | PKCα,immunoprecipitated |
| R5375 | T7221 | T7220 | arg2Of | immunoprecipitated,was |
| R5376 | T7221 | T7222 | arg1Of | immunoprecipitated,from |
| R5377 | T7221 | T7225 | arg1Of | immunoprecipitated,at |
| R5378 | T7221 | T7235 | arg1Of | immunoprecipitated,and |
| R5379 | T7224 | T7222 | arg2Of | MDMs,from |
| R5380 | T7224 | T7223 | arg1Of | MDMs,human |
| R5381 | T7229 | T7225 | arg2Of | points,at |
| R5382 | T7229 | T7226 | arg1Of | points,the |
| R5383 | T7229 | T7227 | arg2Of | points,indicated |
| R5384 | T7229 | T7228 | arg1Of | points,time |
| R5385 | T7229 | T7230 | arg1Of | points,( |
| R5386 | T7231 | T7230 | arg2Of | Figure,( |
| R5387 | T7231 | T7232 | arg1Of | Figure,4 |
| R5388 | T7233 | T7230 | arg3Of | ),( |
| R5389 | T7235 | T7234 | arg1Of | and,"," |
| R5390 | T7240 | T7236 | arg1Of | assay,then |
| R5391 | T7240 | T7237 | arg1Of | assay,a |
| R5392 | T7240 | T7238 | arg1Of | assay,PKC |
| R5393 | T7240 | T7239 | arg1Of | assay,kinase |
| R5394 | T7240 | T7241 | arg1Of | assay,was |
| R5395 | T7240 | T7242 | arg2Of | assay,performed |
| R5396 | T7242 | T7235 | arg2Of | performed,and |
| R5397 | T7242 | T7241 | arg2Of | performed,was |
| R5398 | T7243 | T7242 | arg3Of | using,performed |
| R5399 | T7243 | T7247 | arg1Of | using,as |
| R5400 | T7246 | T7243 | arg2Of | peptide,using |
| R5401 | T7246 | T7244 | arg1Of | peptide,a |
| R5402 | T7246 | T7245 | arg1Of | peptide,fluorescein-tagged |
| R5403 | T7249 | T7247 | arg2Of | substrate,as |
| R5404 | T7249 | T7248 | arg1Of | substrate,a |
| R5405 | T7251 | T7250 | arg2Of | shown,As |
| R5406 | T7251 | T7252 | arg1Of | shown,in |
| R5407 | T7253 | T7252 | arg2Of | Figure,in |
| R5408 | T7253 | T7254 | arg1Of | Figure,4 |
| R5409 | T7253 | T7255 | arg1Of | Figure,( |
| R5410 | T7257 | T7255 | arg2Of | panel,( |
| R5411 | T7257 | T7256 | arg1Of | panel,upper |
| R5412 | T7258 | T7255 | arg3Of | ),( |
| R5413 | T7262 | T7260 | arg1Of | substrate,the |
| R5414 | T7262 | T7261 | arg1Of | substrate,peptide |
| R5415 | T7262 | T7263 | arg1Of | substrate,was |
| R5416 | T7262 | T7265 | arg2Of | substrate,phosphorylated |
| R5417 | T7262 | T7283 | arg1Of | substrate,returned |
| R5418 | T7265 | T7263 | arg2Of | phosphorylated,was |
| R5419 | T7265 | T7264 | arg1Of | phosphorylated,maximally |
| R5420 | T7265 | T7266 | arg1Of | phosphorylated,within |
| R5421 | T7265 | T7271 | arg1Of | phosphorylated,( |
| R5422 | T7265 | T7281 | arg1Of | phosphorylated,and |
| R5423 | T7268 | T7266 | arg2Of | minutes,within |
| R5424 | T7268 | T7267 | arg1Of | minutes,10 |
| R5425 | T7268 | T7269 | arg1Of | minutes,of |
| R5426 | T7270 | T7269 | arg2Of | stimulation,of |
| R5427 | T7272 | T7271 | arg2Of | 1.8-fold,( |
| R5428 | T7272 | T7273 | arg1Of | 1.8-fold,over |
| R5429 | T7275 | T7273 | arg2Of | cells,over |
| R5430 | T7275 | T7274 | arg1Of | cells,resting |
| R5431 | T7275 | T7276 | arg1Of | cells,"," |
| R5432 | T7278 | T7276 | arg2Of | panel,"," |
| R5433 | T7278 | T7277 | arg1Of | panel,lower |
| R5434 | T7279 | T7271 | arg3Of | ),( |
| R5435 | T7281 | T7250 | arg1Of | and,As |
| R5436 | T7281 | T7259 | arg1Of | and,"," |
| R5437 | T7281 | T7280 | arg1Of | and,"," |
| R5438 | T7283 | T7281 | arg2Of | returned,and |
| R5439 | T7283 | T7282 | arg1Of | returned,then |
| R5440 | T7283 | T7284 | arg1Of | returned,to |
| R5441 | T7283 | T7287 | arg1Of | returned,by |
| R5442 | T7286 | T7284 | arg2Of | levels,to |
| R5443 | T7286 | T7285 | arg1Of | levels,basal |
| R5444 | T7289 | T7287 | arg2Of | minutes,by |
| R5445 | T7289 | T7288 | arg1Of | minutes,15 |
| R5446 | T7291 | T7290 | arg1Of | effect,This |
| R5447 | T7291 | T7292 | arg1Of | effect,was |
| R5448 | T7291 | T7294 | arg2Of | effect,seen |
| R5449 | T7294 | T7292 | arg2Of | seen,was |
| R5450 | T7294 | T7293 | arg1Of | seen,not |
| R5451 | T7294 | T7295 | arg1Of | seen,in |
| R5452 | T7294 | T7298 | arg1Of | seen,when |
| R5453 | T7297 | T7295 | arg2Of | monocytes,in |
| R5454 | T7297 | T7296 | arg1Of | monocytes,M-CSF-stimulated |
| R5455 | T7300 | T7299 | arg1Of | antibodies,isogenic |
| R5456 | T7300 | T7301 | arg1Of | antibodies,( |
| R5457 | T7300 | T7304 | arg1Of | antibodies,were |
| R5458 | T7300 | T7305 | arg2Of | antibodies,used |
| R5459 | T7302 | T7301 | arg2Of | IgG,( |
| R5460 | T7303 | T7301 | arg3Of | ),( |
| R5461 | T7305 | T7298 | arg2Of | used,when |
| R5462 | T7305 | T7304 | arg2Of | used,were |
| R5463 | T7305 | T7306 | arg1Of | used,for |
| R5464 | T7307 | T7306 | arg2Of | immunoprecipitation,for |
| R5465 | T7309 | T7308 | arg1Of | blots,Western |
| R5466 | T7309 | T7310 | arg1Of | blots,of |
| R5467 | T7309 | T7318 | arg1Of | blots,demonstrated |
| R5468 | T7312 | T7310 | arg2Of | samples,of |
| R5469 | T7312 | T7311 | arg1Of | samples,identical |
| R5470 | T7312 | T7313 | arg1Of | samples,using |
| R5471 | T7317 | T7313 | arg2Of | PKCα,using |
| R5472 | T7317 | T7314 | arg1Of | PKCα,an |
| R5473 | T7317 | T7315 | arg1Of | PKCα,antibody |
| R5474 | T7317 | T7316 | arg1Of | PKCα,recognizing |
| R5475 | T7321 | T7320 | arg1Of | amounts,equal |
| R5476 | T7321 | T7322 | arg1Of | amounts,of |
| R5477 | T7321 | T7324 | arg1Of | amounts,were |
| R5478 | T7321 | T7325 | arg2Of | amounts,assayed |
| R5479 | T7323 | T7322 | arg2Of | PKCα,of |
| R5480 | T7325 | T7318 | arg2Of | assayed,demonstrated |
| R5481 | T7325 | T7319 | arg1Of | assayed,that |
| R5482 | T7325 | T7324 | arg2Of | assayed,were |
| R5483 | T7325 | T7326 | arg1Of | assayed,( |
| R5484 | T7327 | T7326 | arg2Of | Figure,( |
| R5485 | T7327 | T7328 | arg1Of | Figure,4 |
| R5486 | T7327 | T7329 | arg1Of | Figure,"," |
| R5487 | T7331 | T7329 | arg2Of | panel,"," |
| R5488 | T7331 | T7330 | arg1Of | panel,middle |
| R5489 | T7332 | T7326 | arg3Of | ),( |
| R18506 | T24238 | T24239 | arg1Of | M-CSF,activates |
| R18507 | T24240 | T24239 | arg2Of | PKCα,activates |
| R18508 | T24240 | T24241 | arg1Of | PKCα,in |
| R18509 | T24243 | T24241 | arg2Of | MDMs,in |
| R18510 | T24243 | T24242 | arg1Of | MDMs,human |
| R18511 | T24244 | T24245 | arg2Of | MDMs,treated |
| R18512 | T24244 | T24257 | arg1Of | MDMs,were |
| R18513 | T24244 | T24258 | arg2Of | MDMs,lysed |
| R18514 | T24244 | T24260 | arg2Of | MDMs,immunoprecipitated |
| R18515 | T24244 | T24261 | arg1Of | MDMs,using |
| R18516 | T24245 | T24246 | arg1Of | treated,with |
| R18517 | T24247 | T24246 | arg2Of | M-CSF,with |
| R18518 | T24247 | T24248 | arg1Of | M-CSF,( |
| R18519 | T24247 | T24252 | arg1Of | M-CSF,for |
| R18520 | T24250 | T24248 | arg2Of | ng/ml,( |
| R18521 | T24250 | T24249 | arg1Of | ng/ml,100 |
| R18522 | T24251 | T24248 | arg3Of | ),( |
| R18523 | T24254 | T24252 | arg2Of | amounts,for |
| R18524 | T24254 | T24253 | arg1Of | amounts,varying |
| R18525 | T24254 | T24255 | arg1Of | amounts,of |
| R18526 | T24256 | T24255 | arg2Of | time,of |
| R18527 | T24258 | T24259 | arg1Of | lysed,and |
| R18528 | T24259 | T24257 | arg2Of | and,were |
| R18529 | T24260 | T24259 | arg2Of | immunoprecipitated,and |
| R18530 | T24261 | T24260 | arg3Of | using,immunoprecipitated |
| R18531 | T24263 | T24262 | arg1Of | antibody,anti-PKC |
| R18532 | T24263 | T24264 | arg1Of | antibody,or |
| R18533 | T24264 | T24261 | arg2Of | or,using |
| R18534 | T24267 | T24264 | arg2Of | antibody,or |
| R18535 | T24267 | T24265 | arg1Of | antibody,control |
| R18536 | T24267 | T24266 | arg1Of | antibody,IgG |
| R18537 | T24269 | T24268 | arg1Of | half,One |
| R18538 | T24269 | T24270 | arg1Of | half,of |
| R18539 | T24269 | T24273 | arg1Of | half,was |
| R18540 | T24269 | T24274 | arg2Of | half,used |
| R18541 | T24272 | T24270 | arg2Of | samples,of |
| R18542 | T24272 | T24271 | arg1Of | samples,the |
| R18543 | T24274 | T24273 | arg2Of | used,was |
| R18544 | T24276 | T24274 | arg3Of | analyze,used |
| R18545 | T24276 | T24275 | arg1Of | analyze,to |
| R18546 | T24279 | T24276 | arg2Of | activity,analyze |
| R18547 | T24279 | T24277 | arg1Of | activity,PKC |
| R18548 | T24279 | T24278 | arg1Of | activity,kinase |
| R18549 | T24279 | T24280 | arg1Of | activity,using |
| R18550 | T24282 | T24280 | arg2Of | fluorescein,using |
| R18551 | T24282 | T24281 | arg1Of | fluorescein,a |
| R18552 | T24282 | T24283 | arg2Of | fluorescein,tagged |
| R18553 | T24282 | T24286 | arg2Of | fluorescein,visualized |
| R18554 | T24283 | T24285 | arg1Of | tagged,and |
| R18555 | T24284 | T24283 | arg3Of | peptide,tagged |
| R18556 | T24285 | T24295 | arg1Of | and,"," |
| R18557 | T24285 | T24296 | arg1Of | and,while |
| R18558 | T24286 | T24285 | arg2Of | visualized,and |
| R18559 | T24290 | T24286 | arg1Of | electrophoresis,visualized |
| R18560 | T24290 | T24287 | arg2Of | electrophoresis,by |
| R18561 | T24290 | T24288 | arg1Of | electrophoresis,agarose |
| R18562 | T24290 | T24289 | arg1Of | electrophoresis,gel |
| R18563 | T24290 | T24291 | arg1Of | electrophoresis,( |
| R18564 | T24293 | T24291 | arg2Of | panel,( |
| R18565 | T24293 | T24292 | arg1Of | panel,top |
| R18566 | T24294 | T24291 | arg3Of | ),( |
| R18567 | T24299 | T24297 | arg1Of | half,the |
| R18568 | T24299 | T24298 | arg1Of | half,other |
| R18569 | T24299 | T24300 | arg1Of | half,was |
| R18570 | T24299 | T24301 | arg2Of | half,subjected |
| R18571 | T24301 | T24296 | arg2Of | subjected,while |
| R18572 | T24301 | T24300 | arg2Of | subjected,was |
| R18573 | T24301 | T24302 | arg1Of | subjected,to |
| R18574 | T24301 | T24306 | modOf | subjected,to |
| R18575 | T24305 | T24302 | arg2Of | analysis,to |
| R18576 | T24305 | T24303 | arg1Of | analysis,Western |
| R18577 | T24305 | T24304 | arg1Of | analysis,blot |
| R18578 | T24307 | T24306 | arg1Of | confirm,to |
| R18579 | T24309 | T24308 | arg1Of | amounts,equal |
| R18580 | T24309 | T24310 | arg1Of | amounts,of |
| R18581 | T24309 | T24312 | arg1Of | amounts,were |
| R18582 | T24309 | T24313 | arg2Of | amounts,immunoprecipitated |
| R18583 | T24311 | T24310 | arg2Of | PKCα,of |
| R18584 | T24313 | T24307 | arg2Of | immunoprecipitated,confirm |
| R18585 | T24313 | T24312 | arg2Of | immunoprecipitated,were |
| R18586 | T24313 | T24314 | arg1Of | immunoprecipitated,from |
| R18587 | T24316 | T24314 | arg2Of | sample,from |
| R18588 | T24316 | T24315 | arg1Of | sample,each |
| R18589 | T24316 | T24317 | arg1Of | sample,( |
| R18590 | T24319 | T24317 | arg2Of | panel,( |
| R18591 | T24319 | T24318 | arg1Of | panel,middle |
| R18592 | T24320 | T24317 | arg3Of | ),( |
| R18593 | T24323 | T24321 | arg1Of | assay,The |
| R18594 | T24323 | T24322 | arg1Of | assay,kinase |
| R18595 | T24323 | T24324 | arg1Of | assay,was |
| R18596 | T24323 | T24325 | arg2Of | assay,quantitated |
| R18597 | T24325 | T24324 | arg2Of | quantitated,was |
| R18598 | T24326 | T24325 | arg3Of | using,quantitated |
| R18599 | T24329 | T24326 | arg2Of | software,using |
| R18600 | T24329 | T24327 | arg1Of | software,Quantity |
| R18601 | T24329 | T24328 | arg1Of | software,One |
| R18602 | T24329 | T24330 | arg1Of | software,( |
| R18603 | T24329 | T24333 | arg1Of | software,( |
| R18604 | T24331 | T24330 | arg2Of | Bio-Rad,( |
| R18605 | T24332 | T24330 | arg3Of | ),( |
| R18606 | T24335 | T24333 | arg2Of | panel,( |
| R18607 | T24335 | T24334 | arg1Of | panel,bottom |
| R18608 | T24336 | T24333 | arg3Of | ),( |
| R18609 | T24337 | T24338 | arg1Of | Data,represents |
| R18610 | T24338 | T24349 | arg1Of | represents,compared |
| R18611 | T24342 | T24338 | arg2Of | increase,represents |
| R18612 | T24342 | T24339 | arg1Of | increase,the |
| R18613 | T24342 | T24340 | arg1Of | increase,average |
| R18614 | T24342 | T24341 | arg1Of | increase,fold |
| R18615 | T24342 | T24343 | arg1Of | increase,of |
| R18616 | T24342 | T24346 | arg1Of | increase,in |
| R18617 | T24345 | T24343 | arg2Of | activity,of |
| R18618 | T24345 | T24344 | arg1Of | activity,PKCα |
| R18619 | T24348 | T24346 | arg2Of | samples,in |
| R18620 | T24348 | T24347 | arg1Of | samples,non-stimulated |
| R18621 | T24350 | T24349 | arg2Of | to,compared |
| R18622 | T24354 | T24350 | arg2Of | S.E.M,to |
| R18623 | T24354 | T24351 | arg1Of | S.E.M,M-CSF-treated |
| R18624 | T24354 | T24352 | arg1Of | S.E.M,MDM |
| R18625 | T24354 | T24353 | arg1Of | S.E.M,± |
| R18626 | T24354 | T24355 | arg1Of | S.E.M,for |
| R18627 | T24358 | T24355 | arg2Of | experiments,for |
| R18628 | T24358 | T24356 | arg1Of | experiments,three |
| R18629 | T24358 | T24357 | arg1Of | experiments,independent |
| R18630 | T24359 | T24360 | arg1Of | NS,: |
| R18631 | T24359 | T24361 | arg1Of | NS,non-stimulated. |
| R18632 | T24359 | T24371 | modOf | NS,were |
| R18633 | T24364 | T24362 | arg1Of | p-values,* |
| R18634 | T24364 | T24363 | arg1Of | p-values,The |
| R18635 | T24364 | T24365 | arg1Of | p-values,of |
| R18636 | T24364 | T24371 | arg1Of | p-values,were |
| R18637 | T24364 | T24372 | arg1Of | p-values,≤0.05 |
| R18638 | T24366 | T24365 | arg2Of | M-CSF,of |
| R18639 | T24366 | T24367 | arg2Of | M-CSF,stimulated |
| R18640 | T24367 | T24368 | arg1Of | stimulated,compared |
| R18641 | T24369 | T24368 | arg2Of | to,compared |
| R18642 | T24370 | T24369 | arg2Of | non-stimulated,to |
| R18643 | T24372 | T24371 | arg2Of | ≤0.05,were |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T7008 | 0-34 | Sentence | denotes | M-CSF-Induces PKCα Kinase Activity |
| T7009 | 35-271 | Sentence | denotes | Since our data suggested that conventional PKCs were involved in activating NF-κB in response to M-CSF in primary human macrophages, we next investigated whether the conventional PKC, PKCα was a downstream target of M-CSF in human MDMs. |
| T7010 | 272-449 | Sentence | denotes | PKCα was immunoprecipitated from human MDMs at the indicated time points (Figure 4), and then a PKC kinase assay was performed using a fluorescein-tagged peptide as a substrate. |
| T7011 | 450-662 | Sentence | denotes | As shown in Figure 4 (upper panel), the peptide substrate was maximally phosphorylated within 10 minutes of stimulation (1.8-fold over resting cells, lower panel), and then returned to basal levels by 15 minutes. |
| T7012 | 663-783 | Sentence | denotes | This effect was not seen in M-CSF-stimulated monocytes when isogenic antibodies (IgG) were used for immunoprecipitation. |
| T7013 | 784-932 | Sentence | denotes | Western blots of identical samples using an antibody recognizing PKCα demonstrated that equal amounts of PKCα were assayed (Figure 4, middle panel). |
| T24089 | 977-1012 | Sentence | denotes | M-CSF activates PKCα in human MDMs. |
| T24090 | 1013-1159 | Sentence | denotes | MDMs treated with M-CSF (100 ng/ml) for varying amounts of time were lysed and immunoprecipitated using anti-PKC antibody or control IgG antibody. |
| T24091 | 1160-1467 | Sentence | denotes | One half of the samples was used to analyze PKC kinase activity using a fluorescein tagged peptide and visualized by agarose gel electrophoresis (top panel), while the other half was subjected to Western blot analysis to confirm equal amounts of PKCα were immunoprecipitated from each sample (middle panel). |
| T24092 | 1468-1554 | Sentence | denotes | The kinase assay was quantitated using Quantity One software (Bio-Rad) (bottom panel). |
| T24093 | 1555-1712 | Sentence | denotes | Data represents the average fold increase of PKCα activity in non-stimulated samples compared to M-CSF-treated MDM ± S.E.M for three independent experiments. |
| T24094 | 1713-1806 | Sentence | denotes | NS: non-stimulated. * The p-values of M-CSF stimulated compared to non-stimulated were ≤0.05. |
| T116 | 0-34 | Sentence | denotes | M-CSF-Induces PKCα Kinase Activity |
| T117 | 35-271 | Sentence | denotes | Since our data suggested that conventional PKCs were involved in activating NF-κB in response to M-CSF in primary human macrophages, we next investigated whether the conventional PKC, PKCα was a downstream target of M-CSF in human MDMs. |
| T118 | 272-449 | Sentence | denotes | PKCα was immunoprecipitated from human MDMs at the indicated time points (Figure 4), and then a PKC kinase assay was performed using a fluorescein-tagged peptide as a substrate. |
| T119 | 450-662 | Sentence | denotes | As shown in Figure 4 (upper panel), the peptide substrate was maximally phosphorylated within 10 minutes of stimulation (1.8-fold over resting cells, lower panel), and then returned to basal levels by 15 minutes. |
| T120 | 663-783 | Sentence | denotes | This effect was not seen in M-CSF-stimulated monocytes when isogenic antibodies (IgG) were used for immunoprecipitation. |
| T121 | 784-932 | Sentence | denotes | Western blots of identical samples using an antibody recognizing PKCα demonstrated that equal amounts of PKCα were assayed (Figure 4, middle panel). |
| T122 | 933-1012 | Sentence | denotes | 10.1371/journal.pone.0028081.g004 Figure 4 M-CSF activates PKCα in human MDMs. |
| T123 | 1013-1159 | Sentence | denotes | MDMs treated with M-CSF (100 ng/ml) for varying amounts of time were lysed and immunoprecipitated using anti-PKC antibody or control IgG antibody. |
| T124 | 1160-1467 | Sentence | denotes | One half of the samples was used to analyze PKC kinase activity using a fluorescein tagged peptide and visualized by agarose gel electrophoresis (top panel), while the other half was subjected to Western blot analysis to confirm equal amounts of PKCα were immunoprecipitated from each sample (middle panel). |
| T125 | 1468-1554 | Sentence | denotes | The kinase assay was quantitated using Quantity One software (Bio-Rad) (bottom panel). |
| T126 | 1555-1712 | Sentence | denotes | Data represents the average fold increase of PKCα activity in non-stimulated samples compared to M-CSF-treated MDM ± S.E.M for three independent experiments. |
| T127 | 1713-1806 | Sentence | denotes | NS: non-stimulated. * The p-values of M-CSF stimulated compared to non-stimulated were ≤0.05. |
bionlp-st-ge-2016-spacy-parsed
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T7014 | 0-13 | NNS | denotes | M-CSF-Induces |
| T7015 | 14-18 | NNP | denotes | PKCα |
| T7016 | 19-25 | NNP | denotes | Kinase |
| T7017 | 26-34 | NNP | denotes | Activity |
| T7018 | 35-40 | IN | denotes | Since |
| T7019 | 41-44 | PRP$ | denotes | our |
| T7020 | 45-49 | NNS | denotes | data |
| T7021 | 50-59 | VBD | denotes | suggested |
| T7022 | 60-64 | IN | denotes | that |
| T7023 | 65-77 | JJ | denotes | conventional |
| T7024 | 78-82 | NNS | denotes | PKCs |
| T7025 | 83-87 | VBD | denotes | were |
| T7026 | 88-96 | VBN | denotes | involved |
| T7027 | 97-99 | IN | denotes | in |
| T7028 | 100-110 | VBG | denotes | activating |
| T7029 | 111-116 | NN | denotes | NF-κB |
| T7030 | 117-119 | IN | denotes | in |
| T7031 | 120-128 | NN | denotes | response |
| T7032 | 129-131 | TO | denotes | to |
| T7033 | 132-137 | NNP | denotes | M-CSF |
| T7034 | 138-140 | IN | denotes | in |
| T7035 | 141-148 | JJ | denotes | primary |
| T7036 | 149-154 | JJ | denotes | human |
| T7037 | 155-166 | NNS | denotes | macrophages |
| T7038 | 166-167 | , | denotes | , |
| T7039 | 168-170 | PRP | denotes | we |
| T7040 | 171-175 | JJ | denotes | next |
| T7041 | 176-188 | VBD | denotes | investigated |
| T7042 | 189-196 | IN | denotes | whether |
| T7043 | 197-200 | DT | denotes | the |
| T7044 | 201-213 | JJ | denotes | conventional |
| T7045 | 214-217 | NNP | denotes | PKC |
| T7046 | 217-218 | , | denotes | , |
| T7047 | 219-223 | NNP | denotes | PKCα |
| T7048 | 224-227 | VBD | denotes | was |
| T7049 | 228-229 | DT | denotes | a |
| T7050 | 230-240 | JJ | denotes | downstream |
| T7051 | 241-247 | NN | denotes | target |
| T7052 | 248-250 | IN | denotes | of |
| T7053 | 251-256 | NNP | denotes | M-CSF |
| T7054 | 257-259 | IN | denotes | in |
| T7055 | 260-265 | JJ | denotes | human |
| T7056 | 266-270 | NNS | denotes | MDMs |
| T7057 | 270-271 | . | denotes | . |
| T7058 | 272-276 | NNP | denotes | PKCα |
| T7059 | 277-280 | VBD | denotes | was |
| T7060 | 281-299 | VBN | denotes | immunoprecipitated |
| T7061 | 300-304 | IN | denotes | from |
| T7062 | 305-310 | JJ | denotes | human |
| T7063 | 311-315 | NNS | denotes | MDMs |
| T7064 | 316-318 | IN | denotes | at |
| T7065 | 319-322 | DT | denotes | the |
| T7066 | 323-332 | JJ | denotes | indicated |
| T7067 | 333-337 | NN | denotes | time |
| T7068 | 338-344 | NNS | denotes | points |
| T7069 | 345-346 | -LRB- | denotes | ( |
| T7070 | 346-352 | NN | denotes | Figure |
| T7071 | 353-354 | CD | denotes | 4 |
| T7072 | 354-355 | -RRB- | denotes | ) |
| T7073 | 355-356 | , | denotes | , |
| T7074 | 357-360 | CC | denotes | and |
| T7075 | 361-365 | RB | denotes | then |
| T7076 | 366-367 | DT | denotes | a |
| T7077 | 368-371 | NNP | denotes | PKC |
| T7078 | 372-378 | NN | denotes | kinase |
| T7079 | 379-384 | NN | denotes | assay |
| T7080 | 385-388 | VBD | denotes | was |
| T7081 | 389-398 | VBN | denotes | performed |
| T7082 | 399-404 | VBG | denotes | using |
| T7083 | 405-406 | DT | denotes | a |
| T7084 | 407-425 | JJ | denotes | fluorescein-tagged |
| T7085 | 426-433 | NN | denotes | peptide |
| T7086 | 434-436 | IN | denotes | as |
| T7087 | 437-438 | DT | denotes | a |
| T7088 | 439-448 | NN | denotes | substrate |
| T7089 | 448-449 | . | denotes | . |
| T7090 | 450-452 | IN | denotes | As |
| T7091 | 453-458 | VBN | denotes | shown |
| T7092 | 459-461 | IN | denotes | in |
| T7093 | 462-468 | NN | denotes | Figure |
| T7094 | 469-470 | CD | denotes | 4 |
| T7095 | 471-472 | -LRB- | denotes | ( |
| T7096 | 472-477 | JJ | denotes | upper |
| T7097 | 478-483 | NN | denotes | panel |
| T7098 | 483-484 | -RRB- | denotes | ) |
| T7099 | 484-485 | , | denotes | , |
| T7100 | 486-489 | DT | denotes | the |
| T7101 | 490-497 | NN | denotes | peptide |
| T7102 | 498-507 | NN | denotes | substrate |
| T7103 | 508-511 | VBD | denotes | was |
| T7104 | 512-521 | RB | denotes | maximally |
| T7105 | 522-536 | VBN | denotes | phosphorylated |
| T7106 | 537-543 | IN | denotes | within |
| T7107 | 544-546 | CD | denotes | 10 |
| T7108 | 547-554 | NNS | denotes | minutes |
| T7109 | 555-557 | IN | denotes | of |
| T7110 | 558-569 | NN | denotes | stimulation |
| T7111 | 570-571 | -LRB- | denotes | ( |
| T7112 | 571-579 | JJ | denotes | 1.8-fold |
| T7113 | 580-584 | IN | denotes | over |
| T7114 | 585-592 | VBG | denotes | resting |
| T7115 | 593-598 | NNS | denotes | cells |
| T7116 | 598-599 | , | denotes | , |
| T7117 | 600-605 | JJR | denotes | lower |
| T7118 | 606-611 | NN | denotes | panel |
| T7119 | 611-612 | -RRB- | denotes | ) |
| T7120 | 612-613 | , | denotes | , |
| T7121 | 614-617 | CC | denotes | and |
| T7122 | 618-622 | RB | denotes | then |
| T7123 | 623-631 | VBD | denotes | returned |
| T7124 | 632-634 | TO | denotes | to |
| T7125 | 635-640 | JJ | denotes | basal |
| T7126 | 641-647 | NNS | denotes | levels |
| T7127 | 648-650 | IN | denotes | by |
| T7128 | 651-653 | CD | denotes | 15 |
| T7129 | 654-661 | NNS | denotes | minutes |
| T7130 | 661-662 | . | denotes | . |
| T7131 | 663-667 | DT | denotes | This |
| T7132 | 668-674 | NN | denotes | effect |
| T7133 | 675-678 | VBD | denotes | was |
| T7134 | 679-682 | RB | denotes | not |
| T7135 | 683-687 | VBN | denotes | seen |
| T7136 | 688-690 | IN | denotes | in |
| T7137 | 691-707 | JJ | denotes | M-CSF-stimulated |
| T7138 | 708-717 | NNS | denotes | monocytes |
| T7139 | 718-722 | WRB | denotes | when |
| T7140 | 723-731 | JJ | denotes | isogenic |
| T7141 | 732-742 | NNS | denotes | antibodies |
| T7142 | 743-744 | -LRB- | denotes | ( |
| T7143 | 744-747 | NNP | denotes | IgG |
| T7144 | 747-748 | -RRB- | denotes | ) |
| T7145 | 749-753 | VBD | denotes | were |
| T7146 | 754-758 | VBN | denotes | used |
| T7147 | 759-762 | IN | denotes | for |
| T7148 | 763-782 | NN | denotes | immunoprecipitation |
| T7149 | 782-783 | . | denotes | . |
| T7150 | 784-791 | JJ | denotes | Western |
| T7151 | 792-797 | NNS | denotes | blots |
| T7152 | 798-800 | IN | denotes | of |
| T7153 | 801-810 | JJ | denotes | identical |
| T7154 | 811-818 | NNS | denotes | samples |
| T7155 | 819-824 | VBG | denotes | using |
| T7156 | 825-827 | DT | denotes | an |
| T7157 | 828-836 | NN | denotes | antibody |
| T7158 | 837-848 | VBG | denotes | recognizing |
| T7159 | 849-853 | NNP | denotes | PKCα |
| T7160 | 854-866 | VBD | denotes | demonstrated |
| T7161 | 867-871 | IN | denotes | that |
| T7162 | 872-877 | JJ | denotes | equal |
| T7163 | 878-885 | NNS | denotes | amounts |
| T7164 | 886-888 | IN | denotes | of |
| T7165 | 889-893 | NNP | denotes | PKCα |
| T7166 | 894-898 | VBD | denotes | were |
| T7167 | 899-906 | VBN | denotes | assayed |
| T7168 | 907-908 | -LRB- | denotes | ( |
| T7169 | 908-914 | NN | denotes | Figure |
| T7170 | 915-916 | CD | denotes | 4 |
| T7171 | 916-917 | , | denotes | , |
| T7172 | 918-924 | JJ | denotes | middle |
| T7173 | 925-930 | NN | denotes | panel |
| T7174 | 930-931 | -RRB- | denotes | ) |
| T7175 | 931-932 | . | denotes | . |
| T24095 | 977-982 | NNP | denotes | M-CSF |
| T24096 | 983-992 | VBZ | denotes | activates |
| T24097 | 993-997 | NNP | denotes | PKCα |
| T24098 | 998-1000 | IN | denotes | in |
| T24099 | 1001-1006 | JJ | denotes | human |
| T24100 | 1007-1011 | NNS | denotes | MDMs |
| T24101 | 1011-1012 | . | denotes | . |
| T24102 | 1013-1017 | NNS | denotes | MDMs |
| T24103 | 1018-1025 | VBN | denotes | treated |
| T24104 | 1026-1030 | IN | denotes | with |
| T24105 | 1031-1036 | NNP | denotes | M-CSF |
| T24106 | 1037-1038 | -LRB- | denotes | ( |
| T24107 | 1038-1041 | CD | denotes | 100 |
| T24108 | 1042-1047 | NN | denotes | ng/ml |
| T24109 | 1047-1048 | -RRB- | denotes | ) |
| T24110 | 1049-1052 | IN | denotes | for |
| T24111 | 1053-1060 | VBG | denotes | varying |
| T24112 | 1061-1068 | NNS | denotes | amounts |
| T24113 | 1069-1071 | IN | denotes | of |
| T24114 | 1072-1076 | NN | denotes | time |
| T24115 | 1077-1081 | VBD | denotes | were |
| T24116 | 1082-1087 | VBN | denotes | lysed |
| T24117 | 1088-1091 | CC | denotes | and |
| T24118 | 1092-1110 | VBN | denotes | immunoprecipitated |
| T24119 | 1111-1116 | VBG | denotes | using |
| T24120 | 1117-1125 | JJ | denotes | anti-PKC |
| T24121 | 1126-1134 | NN | denotes | antibody |
| T24122 | 1135-1137 | CC | denotes | or |
| T24123 | 1138-1145 | NN | denotes | control |
| T24124 | 1146-1149 | NNP | denotes | IgG |
| T24125 | 1150-1158 | NN | denotes | antibody |
| T24126 | 1158-1159 | . | denotes | . |
| T24127 | 1160-1163 | CD | denotes | One |
| T24128 | 1164-1168 | NN | denotes | half |
| T24129 | 1169-1171 | IN | denotes | of |
| T24130 | 1172-1175 | DT | denotes | the |
| T24131 | 1176-1183 | NNS | denotes | samples |
| T24132 | 1184-1187 | VBD | denotes | was |
| T24133 | 1188-1192 | VBN | denotes | used |
| T24134 | 1193-1195 | TO | denotes | to |
| T24135 | 1196-1203 | VB | denotes | analyze |
| T24136 | 1204-1207 | NNP | denotes | PKC |
| T24137 | 1208-1214 | NN | denotes | kinase |
| T24138 | 1215-1223 | NN | denotes | activity |
| T24139 | 1224-1229 | VBG | denotes | using |
| T24140 | 1230-1231 | DT | denotes | a |
| T24141 | 1232-1243 | NN | denotes | fluorescein |
| T24142 | 1244-1250 | VBD | denotes | tagged |
| T24143 | 1251-1258 | NN | denotes | peptide |
| T24144 | 1259-1262 | CC | denotes | and |
| T24145 | 1263-1273 | VBN | denotes | visualized |
| T24146 | 1274-1276 | IN | denotes | by |
| T24147 | 1277-1284 | JJ | denotes | agarose |
| T24148 | 1285-1288 | NN | denotes | gel |
| T24149 | 1289-1304 | NN | denotes | electrophoresis |
| T24150 | 1305-1306 | -LRB- | denotes | ( |
| T24151 | 1306-1309 | JJ | denotes | top |
| T24152 | 1310-1315 | NN | denotes | panel |
| T24153 | 1315-1316 | -RRB- | denotes | ) |
| T24154 | 1316-1317 | , | denotes | , |
| T24155 | 1318-1323 | IN | denotes | while |
| T24156 | 1324-1327 | DT | denotes | the |
| T24157 | 1328-1333 | JJ | denotes | other |
| T24158 | 1334-1338 | NN | denotes | half |
| T24159 | 1339-1342 | VBD | denotes | was |
| T24160 | 1343-1352 | VBN | denotes | subjected |
| T24161 | 1353-1355 | TO | denotes | to |
| T24162 | 1356-1363 | JJ | denotes | Western |
| T24163 | 1364-1368 | NN | denotes | blot |
| T24164 | 1369-1377 | NN | denotes | analysis |
| T24165 | 1378-1380 | TO | denotes | to |
| T24166 | 1381-1388 | VB | denotes | confirm |
| T24167 | 1389-1394 | JJ | denotes | equal |
| T24168 | 1395-1402 | NNS | denotes | amounts |
| T24169 | 1403-1405 | IN | denotes | of |
| T24170 | 1406-1410 | NNP | denotes | PKCα |
| T24171 | 1411-1415 | VBD | denotes | were |
| T24172 | 1416-1434 | VBN | denotes | immunoprecipitated |
| T24173 | 1435-1439 | IN | denotes | from |
| T24174 | 1440-1444 | DT | denotes | each |
| T24175 | 1445-1451 | NN | denotes | sample |
| T24176 | 1452-1453 | -LRB- | denotes | ( |
| T24177 | 1453-1459 | JJ | denotes | middle |
| T24178 | 1460-1465 | NN | denotes | panel |
| T24179 | 1465-1466 | -RRB- | denotes | ) |
| T24180 | 1466-1467 | . | denotes | . |
| T24181 | 1468-1471 | DT | denotes | The |
| T24182 | 1472-1478 | NN | denotes | kinase |
| T24183 | 1479-1484 | NN | denotes | assay |
| T24184 | 1485-1488 | VBD | denotes | was |
| T24185 | 1489-1500 | VBN | denotes | quantitated |
| T24186 | 1501-1506 | VBG | denotes | using |
| T24187 | 1507-1515 | NNP | denotes | Quantity |
| T24188 | 1516-1519 | CD | denotes | One |
| T24189 | 1520-1528 | NN | denotes | software |
| T24190 | 1529-1530 | -LRB- | denotes | ( |
| T24191 | 1530-1537 | NNP | denotes | Bio-Rad |
| T24192 | 1537-1538 | -RRB- | denotes | ) |
| T24193 | 1539-1540 | -LRB- | denotes | ( |
| T24194 | 1540-1546 | JJ | denotes | bottom |
| T24195 | 1547-1552 | NN | denotes | panel |
| T24196 | 1552-1553 | -RRB- | denotes | ) |
| T24197 | 1553-1554 | . | denotes | . |
| T24198 | 1555-1559 | NNP | denotes | Data |
| T24199 | 1560-1570 | VBZ | denotes | represents |
| T24200 | 1571-1574 | DT | denotes | the |
| T24201 | 1575-1582 | JJ | denotes | average |
| T24202 | 1583-1587 | VBP | denotes | fold |
| T24203 | 1588-1596 | NN | denotes | increase |
| T24204 | 1597-1599 | IN | denotes | of |
| T24205 | 1600-1604 | NN | denotes | PKCα |
| T24206 | 1605-1613 | NN | denotes | activity |
| T24207 | 1614-1616 | IN | denotes | in |
| T24208 | 1617-1631 | JJ | denotes | non-stimulated |
| T24209 | 1632-1639 | NNS | denotes | samples |
| T24210 | 1640-1648 | VBN | denotes | compared |
| T24211 | 1649-1651 | TO | denotes | to |
| T24212 | 1652-1665 | JJ | denotes | M-CSF-treated |
| T24213 | 1666-1669 | NNP | denotes | MDM |
| T24214 | 1670-1671 | NN | denotes | ± |
| T24215 | 1672-1677 | NNP | denotes | S.E.M |
| T24216 | 1678-1681 | IN | denotes | for |
| T24217 | 1682-1687 | CD | denotes | three |
| T24218 | 1688-1699 | JJ | denotes | independent |
| T24219 | 1700-1711 | NNS | denotes | experiments |
| T24220 | 1711-1712 | . | denotes | . |
| T24221 | 1713-1715 | NNP | denotes | NS |
| T24222 | 1715-1716 | : | denotes | : |
| T24223 | 1717-1731 | JJ | denotes | non-stimulated |
| T24224 | 1731-1732 | . | denotes | . |
| T24225 | 1733-1734 | SYM | denotes | * |
| T24226 | 1735-1738 | DT | denotes | The |
| T24227 | 1739-1747 | NNS | denotes | p-values |
| T24228 | 1748-1750 | IN | denotes | of |
| T24229 | 1751-1756 | NNP | denotes | M-CSF |
| T24230 | 1757-1767 | VBD | denotes | stimulated |
| T24231 | 1768-1776 | VBN | denotes | compared |
| T24232 | 1777-1779 | TO | denotes | to |
| T24233 | 1780-1794 | JJ | denotes | non-stimulated |
| T24234 | 1795-1799 | VBD | denotes | were |
| T24235 | 1800-1801 | CD | denotes | ≤ |
| T24236 | 1801-1805 | CD | denotes | 0.05 |
| T24237 | 1805-1806 | . | denotes | . |
| R5169 | T7014 | T7017 | compound | M-CSF-Induces,Activity |
| R5170 | T7015 | T7017 | compound | PKCα,Activity |
| R5171 | T7016 | T7017 | compound | Kinase,Activity |
| R5172 | T7017 | T7021 | nsubj | Activity,suggested |
| R5173 | T7018 | T7021 | mark | Since,suggested |
| R5174 | T7019 | T7020 | poss | our,data |
| R5175 | T7020 | T7021 | nsubj | data,suggested |
| R5176 | T7021 | T7041 | advcl | suggested,investigated |
| R5177 | T7022 | T7026 | mark | that,involved |
| R5178 | T7023 | T7024 | amod | conventional,PKCs |
| R5179 | T7024 | T7026 | nsubjpass | PKCs,involved |
| R5180 | T7025 | T7026 | auxpass | were,involved |
| R5181 | T7026 | T7021 | ccomp | involved,suggested |
| R5182 | T7027 | T7026 | prep | in,involved |
| R5183 | T7028 | T7027 | pcomp | activating,in |
| R5184 | T7029 | T7028 | dobj | NF-κB,activating |
| R5185 | T7030 | T7028 | prep | in,activating |
| R5186 | T7031 | T7030 | pobj | response,in |
| R5187 | T7032 | T7031 | prep | to,response |
| R5188 | T7033 | T7032 | pobj | M-CSF,to |
| R5189 | T7034 | T7033 | prep | in,M-CSF |
| R5190 | T7035 | T7037 | amod | primary,macrophages |
| R5191 | T7036 | T7037 | amod | human,macrophages |
| R5192 | T7037 | T7034 | pobj | macrophages,in |
| R5193 | T7038 | T7041 | punct | ",",investigated |
| R5194 | T7039 | T7041 | nsubj | we,investigated |
| R5195 | T7040 | T7041 | advmod | next,investigated |
| R5196 | T7041 | T7041 | ROOT | investigated,investigated |
| R5197 | T7042 | T7048 | mark | whether,was |
| R5198 | T7043 | T7045 | det | the,PKC |
| R5199 | T7044 | T7045 | amod | conventional,PKC |
| R5200 | T7045 | T7048 | nsubj | PKC,was |
| R5201 | T7046 | T7048 | punct | ",",was |
| R5202 | T7047 | T7048 | nsubj | PKCα,was |
| R5203 | T7048 | T7041 | ccomp | was,investigated |
| R5204 | T7049 | T7051 | det | a,target |
| R5205 | T7050 | T7051 | amod | downstream,target |
| R5206 | T7051 | T7048 | attr | target,was |
| R5207 | T7052 | T7051 | prep | of,target |
| R5208 | T7053 | T7052 | pobj | M-CSF,of |
| R5209 | T7054 | T7051 | prep | in,target |
| R5210 | T7055 | T7056 | amod | human,MDMs |
| R5211 | T7056 | T7054 | pobj | MDMs,in |
| R5212 | T7057 | T7041 | punct | .,investigated |
| R5213 | T7058 | T7060 | nsubjpass | PKCα,immunoprecipitated |
| R5214 | T7059 | T7060 | auxpass | was,immunoprecipitated |
| R5215 | T7060 | T7060 | ROOT | immunoprecipitated,immunoprecipitated |
| R5216 | T7061 | T7060 | prep | from,immunoprecipitated |
| R5217 | T7062 | T7063 | amod | human,MDMs |
| R5218 | T7063 | T7061 | pobj | MDMs,from |
| R5219 | T7064 | T7060 | prep | at,immunoprecipitated |
| R5220 | T7065 | T7067 | det | the,time |
| R5221 | T7066 | T7067 | amod | indicated,time |
| R5222 | T7067 | T7064 | pobj | time,at |
| R5223 | T7068 | T7081 | advmod | points,performed |
| R5224 | T7069 | T7070 | punct | (,Figure |
| R5225 | T7070 | T7068 | appos | Figure,points |
| R5226 | T7071 | T7070 | nummod | 4,Figure |
| R5227 | T7072 | T7070 | punct | ),Figure |
| R5228 | T7073 | T7070 | punct | ",",Figure |
| R5229 | T7074 | T7070 | cc | and,Figure |
| R5230 | T7075 | T7081 | advmod | then,performed |
| R5231 | T7076 | T7079 | det | a,assay |
| R5232 | T7077 | T7079 | compound | PKC,assay |
| R5233 | T7078 | T7079 | compound | kinase,assay |
| R5234 | T7079 | T7081 | nsubjpass | assay,performed |
| R5235 | T7080 | T7081 | auxpass | was,performed |
| R5236 | T7081 | T7081 | ROOT | performed,performed |
| R5237 | T7082 | T7081 | advcl | using,performed |
| R5238 | T7083 | T7085 | det | a,peptide |
| R5239 | T7084 | T7085 | amod | fluorescein-tagged,peptide |
| R5240 | T7085 | T7082 | dobj | peptide,using |
| R5241 | T7086 | T7082 | prep | as,using |
| R5242 | T7087 | T7088 | det | a,substrate |
| R5243 | T7088 | T7086 | pobj | substrate,as |
| R5244 | T7089 | T7081 | punct | .,performed |
| R5245 | T7090 | T7091 | mark | As,shown |
| R5246 | T7091 | T7103 | advcl | shown,was |
| R5247 | T7092 | T7091 | prep | in,shown |
| R5248 | T7093 | T7092 | pobj | Figure,in |
| R5249 | T7094 | T7093 | nummod | 4,Figure |
| R5250 | T7095 | T7097 | punct | (,panel |
| R5251 | T7096 | T7097 | amod | upper,panel |
| R5252 | T7097 | T7093 | appos | panel,Figure |
| R5253 | T7098 | T7093 | punct | ),Figure |
| R5254 | T7099 | T7103 | punct | ",",was |
| R5255 | T7100 | T7102 | det | the,substrate |
| R5256 | T7101 | T7102 | compound | peptide,substrate |
| R5257 | T7102 | T7103 | nsubj | substrate,was |
| R5258 | T7103 | T7103 | ROOT | was,was |
| R5259 | T7104 | T7105 | advmod | maximally,phosphorylated |
| R5260 | T7105 | T7103 | acomp | phosphorylated,was |
| R5261 | T7106 | T7105 | prep | within,phosphorylated |
| R5262 | T7107 | T7108 | nummod | 10,minutes |
| R5263 | T7108 | T7106 | pobj | minutes,within |
| R5264 | T7109 | T7108 | prep | of,minutes |
| R5265 | T7110 | T7109 | pobj | stimulation,of |
| R5266 | T7111 | T7112 | punct | (,1.8-fold |
| R5267 | T7112 | T7105 | appos | 1.8-fold,phosphorylated |
| R5268 | T7113 | T7112 | prep | over,1.8-fold |
| R5269 | T7114 | T7115 | amod | resting,cells |
| R5270 | T7115 | T7113 | pobj | cells,over |
| R5271 | T7116 | T7112 | punct | ",",1.8-fold |
| R5272 | T7117 | T7118 | amod | lower,panel |
| R5273 | T7118 | T7112 | appos | panel,1.8-fold |
| R5274 | T7119 | T7112 | punct | ),1.8-fold |
| R5275 | T7120 | T7112 | punct | ",",1.8-fold |
| R5276 | T7121 | T7105 | cc | and,phosphorylated |
| R5277 | T7122 | T7123 | advmod | then,returned |
| R5278 | T7123 | T7103 | conj | returned,was |
| R5279 | T7124 | T7123 | prep | to,returned |
| R5280 | T7125 | T7126 | amod | basal,levels |
| R5281 | T7126 | T7124 | pobj | levels,to |
| R5282 | T7127 | T7123 | prep | by,returned |
| R5283 | T7128 | T7129 | nummod | 15,minutes |
| R5284 | T7129 | T7127 | pobj | minutes,by |
| R5285 | T7130 | T7123 | punct | .,returned |
| R5286 | T7131 | T7132 | det | This,effect |
| R5287 | T7132 | T7135 | nsubjpass | effect,seen |
| R5288 | T7133 | T7135 | auxpass | was,seen |
| R5289 | T7134 | T7135 | neg | not,seen |
| R5290 | T7135 | T7135 | ROOT | seen,seen |
| R5291 | T7136 | T7135 | prep | in,seen |
| R5292 | T7137 | T7138 | amod | M-CSF-stimulated,monocytes |
| R5293 | T7138 | T7136 | pobj | monocytes,in |
| R5294 | T7139 | T7146 | advmod | when,used |
| R5295 | T7140 | T7141 | amod | isogenic,antibodies |
| R5296 | T7141 | T7146 | nsubjpass | antibodies,used |
| R5297 | T7142 | T7143 | punct | (,IgG |
| R5298 | T7143 | T7141 | appos | IgG,antibodies |
| R5299 | T7144 | T7141 | punct | ),antibodies |
| R5300 | T7145 | T7146 | auxpass | were,used |
| R5301 | T7146 | T7135 | advcl | used,seen |
| R5302 | T7147 | T7146 | prep | for,used |
| R5303 | T7148 | T7147 | pobj | immunoprecipitation,for |
| R5304 | T7149 | T7135 | punct | .,seen |
| R5305 | T7150 | T7151 | amod | Western,blots |
| R5306 | T7151 | T7160 | nsubj | blots,demonstrated |
| R5307 | T7152 | T7151 | prep | of,blots |
| R5308 | T7153 | T7154 | amod | identical,samples |
| R5309 | T7154 | T7152 | pobj | samples,of |
| R5310 | T7155 | T7151 | acl | using,blots |
| R5311 | T7156 | T7157 | det | an,antibody |
| R5312 | T7157 | T7155 | dobj | antibody,using |
| R5313 | T7158 | T7155 | advcl | recognizing,using |
| R5314 | T7159 | T7160 | nsubj | PKCα,demonstrated |
| R5315 | T7160 | T7160 | ROOT | demonstrated,demonstrated |
| R5316 | T7161 | T7167 | mark | that,assayed |
| R5317 | T7162 | T7163 | amod | equal,amounts |
| R5318 | T7163 | T7167 | nsubjpass | amounts,assayed |
| R5319 | T7164 | T7163 | prep | of,amounts |
| R5320 | T7165 | T7164 | pobj | PKCα,of |
| R5321 | T7166 | T7167 | auxpass | were,assayed |
| R5322 | T7167 | T7160 | ccomp | assayed,demonstrated |
| R5323 | T7168 | T7169 | punct | (,Figure |
| R5324 | T7169 | T7167 | oprd | Figure,assayed |
| R5325 | T7170 | T7169 | nummod | 4,Figure |
| R5326 | T7171 | T7169 | punct | ",",Figure |
| R5327 | T7172 | T7173 | amod | middle,panel |
| R5328 | T7173 | T7169 | appos | panel,Figure |
| R5329 | T7174 | T7169 | punct | ),Figure |
| R5330 | T7175 | T7160 | punct | .,demonstrated |
| R18363 | T24095 | T24096 | nsubj | M-CSF,activates |
| R18364 | T24096 | T24096 | ROOT | activates,activates |
| R18365 | T24097 | T24096 | dobj | PKCα,activates |
| R18366 | T24098 | T24096 | prep | in,activates |
| R18367 | T24099 | T24100 | amod | human,MDMs |
| R18368 | T24100 | T24098 | pobj | MDMs,in |
| R18369 | T24101 | T24096 | punct | .,activates |
| R18370 | T24102 | T24116 | nsubjpass | MDMs,lysed |
| R18371 | T24103 | T24102 | acl | treated,MDMs |
| R18372 | T24104 | T24103 | prep | with,treated |
| R18373 | T24105 | T24104 | pobj | M-CSF,with |
| R18374 | T24106 | T24108 | punct | (,ng/ml |
| R18375 | T24107 | T24108 | nummod | 100,ng/ml |
| R18376 | T24108 | T24105 | appos | ng/ml,M-CSF |
| R18377 | T24109 | T24103 | punct | ),treated |
| R18378 | T24110 | T24103 | prep | for,treated |
| R18379 | T24111 | T24112 | amod | varying,amounts |
| R18380 | T24112 | T24110 | pobj | amounts,for |
| R18381 | T24113 | T24112 | prep | of,amounts |
| R18382 | T24114 | T24113 | pobj | time,of |
| R18383 | T24115 | T24116 | auxpass | were,lysed |
| R18384 | T24116 | T24116 | ROOT | lysed,lysed |
| R18385 | T24117 | T24116 | cc | and,lysed |
| R18386 | T24118 | T24116 | conj | immunoprecipitated,lysed |
| R18387 | T24119 | T24118 | advcl | using,immunoprecipitated |
| R18388 | T24120 | T24121 | amod | anti-PKC,antibody |
| R18389 | T24121 | T24119 | dobj | antibody,using |
| R18390 | T24122 | T24121 | cc | or,antibody |
| R18391 | T24123 | T24121 | conj | control,antibody |
| R18392 | T24124 | T24125 | compound | IgG,antibody |
| R18393 | T24125 | T24121 | conj | antibody,antibody |
| R18394 | T24126 | T24116 | punct | .,lysed |
| R18395 | T24127 | T24128 | nummod | One,half |
| R18396 | T24128 | T24133 | nsubjpass | half,used |
| R18397 | T24129 | T24128 | prep | of,half |
| R18398 | T24130 | T24131 | det | the,samples |
| R18399 | T24131 | T24129 | pobj | samples,of |
| R18400 | T24132 | T24133 | auxpass | was,used |
| R18401 | T24133 | T24133 | ROOT | used,used |
| R18402 | T24134 | T24135 | aux | to,analyze |
| R18403 | T24135 | T24133 | xcomp | analyze,used |
| R18404 | T24136 | T24138 | compound | PKC,activity |
| R18405 | T24137 | T24138 | compound | kinase,activity |
| R18406 | T24138 | T24135 | dobj | activity,analyze |
| R18407 | T24139 | T24135 | advcl | using,analyze |
| R18408 | T24140 | T24141 | det | a,fluorescein |
| R18409 | T24141 | T24139 | dobj | fluorescein,using |
| R18410 | T24142 | T24133 | conj | tagged,used |
| R18411 | T24143 | T24142 | dobj | peptide,tagged |
| R18412 | T24144 | T24142 | cc | and,tagged |
| R18413 | T24145 | T24142 | conj | visualized,tagged |
| R18414 | T24146 | T24145 | agent | by,visualized |
| R18415 | T24147 | T24149 | amod | agarose,electrophoresis |
| R18416 | T24148 | T24149 | compound | gel,electrophoresis |
| R18417 | T24149 | T24146 | pobj | electrophoresis,by |
| R18418 | T24150 | T24149 | punct | (,electrophoresis |
| R18419 | T24151 | T24152 | amod | top,panel |
| R18420 | T24152 | T24149 | appos | panel,electrophoresis |
| R18421 | T24153 | T24149 | punct | ),electrophoresis |
| R18422 | T24154 | T24142 | punct | ",",tagged |
| R18423 | T24155 | T24160 | mark | while,subjected |
| R18424 | T24156 | T24158 | det | the,half |
| R18425 | T24157 | T24158 | amod | other,half |
| R18426 | T24158 | T24160 | nsubjpass | half,subjected |
| R18427 | T24159 | T24160 | auxpass | was,subjected |
| R18428 | T24160 | T24142 | advcl | subjected,tagged |
| R18429 | T24161 | T24160 | prep | to,subjected |
| R18430 | T24162 | T24164 | amod | Western,analysis |
| R18431 | T24163 | T24164 | compound | blot,analysis |
| R18432 | T24164 | T24161 | pobj | analysis,to |
| R18433 | T24165 | T24166 | aux | to,confirm |
| R18434 | T24166 | T24160 | xcomp | confirm,subjected |
| R18435 | T24167 | T24168 | amod | equal,amounts |
| R18436 | T24168 | T24166 | dobj | amounts,confirm |
| R18437 | T24169 | T24168 | prep | of,amounts |
| R18438 | T24170 | T24169 | pobj | PKCα,of |
| R18439 | T24171 | T24172 | auxpass | were,immunoprecipitated |
| R18440 | T24172 | T24142 | conj | immunoprecipitated,tagged |
| R18441 | T24173 | T24172 | prep | from,immunoprecipitated |
| R18442 | T24174 | T24175 | det | each,sample |
| R18443 | T24175 | T24173 | pobj | sample,from |
| R18444 | T24176 | T24178 | punct | (,panel |
| R18445 | T24177 | T24178 | amod | middle,panel |
| R18446 | T24178 | T24175 | appos | panel,sample |
| R18447 | T24179 | T24172 | punct | ),immunoprecipitated |
| R18448 | T24180 | T24133 | punct | .,used |
| R18449 | T24181 | T24183 | det | The,assay |
| R18450 | T24182 | T24183 | compound | kinase,assay |
| R18451 | T24183 | T24185 | nsubjpass | assay,quantitated |
| R18452 | T24184 | T24185 | auxpass | was,quantitated |
| R18453 | T24185 | T24185 | ROOT | quantitated,quantitated |
| R18454 | T24186 | T24185 | advcl | using,quantitated |
| R18455 | T24187 | T24186 | dobj | Quantity,using |
| R18456 | T24188 | T24189 | nummod | One,software |
| R18457 | T24189 | T24195 | nmod | software,panel |
| R18458 | T24190 | T24191 | punct | (,Bio-Rad |
| R18459 | T24191 | T24189 | appos | Bio-Rad,software |
| R18460 | T24192 | T24189 | punct | ),software |
| R18461 | T24193 | T24195 | punct | (,panel |
| R18462 | T24194 | T24195 | amod | bottom,panel |
| R18463 | T24195 | T24187 | appos | panel,Quantity |
| R18464 | T24196 | T24187 | punct | ),Quantity |
| R18465 | T24197 | T24185 | punct | .,quantitated |
| R18466 | T24198 | T24199 | nsubj | Data,represents |
| R18467 | T24199 | T24199 | ROOT | represents,represents |
| R18468 | T24200 | T24203 | det | the,increase |
| R18469 | T24201 | T24202 | amod | average,fold |
| R18470 | T24202 | T24203 | compound | fold,increase |
| R18471 | T24203 | T24199 | dobj | increase,represents |
| R18472 | T24204 | T24203 | prep | of,increase |
| R18473 | T24205 | T24206 | compound | PKCα,activity |
| R18474 | T24206 | T24204 | pobj | activity,of |
| R18475 | T24207 | T24206 | prep | in,activity |
| R18476 | T24208 | T24209 | amod | non-stimulated,samples |
| R18477 | T24209 | T24207 | pobj | samples,in |
| R18478 | T24210 | T24199 | prep | compared,represents |
| R18479 | T24211 | T24210 | prep | to,compared |
| R18480 | T24212 | T24215 | compound | M-CSF-treated,S.E.M |
| R18481 | T24213 | T24214 | compound | MDM,± |
| R18482 | T24214 | T24215 | compound | ±,S.E.M |
| R18483 | T24215 | T24211 | pobj | S.E.M,to |
| R18484 | T24216 | T24210 | prep | for,compared |
| R18485 | T24217 | T24219 | nummod | three,experiments |
| R18486 | T24218 | T24219 | amod | independent,experiments |
| R18487 | T24219 | T24216 | pobj | experiments,for |
| R18488 | T24220 | T24199 | punct | .,represents |
| R18489 | T24221 | T24221 | ROOT | NS,NS |
| R18490 | T24222 | T24221 | punct | :,NS |
| R18491 | T24223 | T24221 | acl | non-stimulated,NS |
| R18492 | T24224 | T24221 | punct | .,NS |
| R18493 | T24225 | T24225 | ROOT | *,* |
| R18494 | T24226 | T24227 | det | The,p-values |
| R18495 | T24227 | T24230 | nsubj | p-values,stimulated |
| R18496 | T24228 | T24227 | prep | of,p-values |
| R18497 | T24229 | T24228 | pobj | M-CSF,of |
| R18498 | T24230 | T24230 | ROOT | stimulated,stimulated |
| R18499 | T24231 | T24230 | prep | compared,stimulated |
| R18500 | T24232 | T24231 | prep | to,compared |
| R18501 | T24233 | T24232 | pobj | non-stimulated,to |
| R18502 | T24234 | T24230 | conj | were,stimulated |
| R18503 | T24235 | T24236 | compound | ≤,0.05 |
| R18504 | T24236 | T24234 | attr | 0.05,were |
| R18505 | T24237 | T24230 | punct | .,stimulated |
test2
| Id | Subject | Object | Predicate | Lexical cue | Speculation |
|---|---|---|---|---|---|
| T7000 | 0-5 | Protein | denotes | M-CSF | true |
| T7001 | 6-13 | Positive_regulation | denotes | Induces | |
| T7002 | 14-18 | Protein | denotes | PKCα | |
| T7003 | 132-137 | Protein | denotes | M-CSF | |
| T7004 | 219-223 | Protein | denotes | PKCα | |
| T7005 | 251-256 | Protein | denotes | M-CSF | |
| T7006 | 522-536 | Phosphorylation | denotes | phosphorylated | |
| T7007 | 691-696 | Protein | denotes | M-CSF | |
| T24080 | 977-982 | Protein | denotes | M-CSF | |
| T24081 | 983-992 | Positive_regulation | denotes | activates | |
| T24082 | 993-997 | Protein | denotes | PKCα | |
| T24083 | 1031-1036 | Protein | denotes | M-CSF | |
| T24084 | 1406-1410 | Protein | denotes | PKCα | |
| T24085 | 1588-1596 | Positive_regulation | denotes | increase | |
| T24086 | 1600-1604 | Protein | denotes | PKCα | |
| T24087 | 1652-1657 | Protein | denotes | M-CSF | |
| T24088 | 1751-1756 | Protein | denotes | M-CSF | |
| R5168 | T7000 | T7001 | causeOf | M-CSF,Induces | |
| R18359 | T24080 | T24081 | causeOf | M-CSF,activates | |
| R18360 | T24082 | T24081 | themeOf | PKCα,activates | |
| R18361 | T24086 | T24085 | themeOf | PKCα,increase | |
| R18362 | T24087 | T24085 | causeOf | M-CSF,increase |