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bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T3308 162-198 P09603 denotes Macrophage colony-stimulating factor
T3309 173-198 P04141 denotes colony-stimulating factor
T3310 200-205 P09603 denotes M-CSF
T3311 202-205 P04141 denotes CSF
T3312 287-292 P09603 denotes M-CSF
T3313 289-292 P04141 denotes CSF
T3314 543-548 P09603 denotes M-CSF
T3315 545-548 P04141 denotes CSF
T3316 866-870 Q04206-3 denotes RelA
T3317 866-870 Q04206 denotes RelA
T3318 871-874 P21579 denotes p65
T3319 871-874 Q04206 denotes p65
T3320 876-879 P19838 denotes p50
T3321 881-884 Q00653 denotes p52
T3322 886-891 Q04864 denotes c-Rel
T3323 888-891 Q04864 denotes Rel
T3324 896-900 Q01201 denotes RelB
T3325 944-947 P19838 denotes p50
T3326 948-951 Q04206 denotes p65
T3327 948-951 P21579 denotes p65
T3328 1010-1013 Q04206 denotes p65
T3329 1010-1013 P21579 denotes p65
T3330 1029-1032 Q04206 denotes p65
T3331 1029-1032 P21579 denotes p65
T3332 1107-1110 P21579 denotes p65
T3333 1107-1110 Q04206 denotes p65
T3334 1217-1220 P21579 denotes p65
T3335 1217-1220 Q04206 denotes p65
T3336 1318-1321 Q04206 denotes p65
T3337 1318-1321 P21579 denotes p65
T3338 1984-1987 P19838 denotes p50
T3339 1988-1991 Q04206 denotes p65
T3340 1988-1991 P21579 denotes p65
T3341 2033-2037 P25963 denotes IκBα
T3342 2091-2095 P25963 denotes IκBα
T3343 2160-2163 P19838 denotes p50
T3344 2164-2167 P21579 denotes p65
T3345 2164-2167 Q04206 denotes p65
T3346 2253-2257 P25963 denotes IκBα
T3347 2265-2268 Q04206 denotes p65
T3348 2265-2268 P21579 denotes p65
T3349 2363-2366 Q04206 denotes p65
T3350 2363-2366 P21579 denotes p65
T3351 2531-2534 P21579 denotes p65
T3352 2531-2534 Q04206 denotes p65
T3353 2693-2696 Q04206 denotes p65
T3354 2693-2696 P21579 denotes p65
T3355 2718-2722 O75582 denotes MSK1
T3356 2948-2952 O14920 denotes IKKβ
T3357 3001-3004 P21579 denotes p65
T3358 3001-3004 Q04206 denotes p65
T3359 3068-3071 Q04206 denotes p65
T3360 3068-3071 P21579 denotes p65
T3361 3172-3175 P21579 denotes p65
T3362 3172-3175 Q04206 denotes p65
T3363 3310-3313 Q04206 denotes p65
T3364 3310-3313 P21579 denotes p65
T3365 3362-3366 Q09472 denotes p300
T3366 3515-3519 P25963 denotes IκBα
T3367 3611-3614 P21579 denotes p65
T3368 3611-3614 Q04206 denotes p65
T3369 3848-3853 P09603 denotes M-CSF
T3370 3850-3853 P04141 denotes CSF
T3371 4446-4450 P17252 denotes PKCα
T3372 4461-4467 P05771 denotes PKCβII
T3373 4485-4489 Q05655 denotes PKCδ
T3374 4616-4620 P17252 denotes PKCα
T3375 4784-4788 P17252 denotes PKCα
T3376 4833-4837 P17252 denotes PKCα
T3377 4965-4969 P17252 denotes PKCα
T3378 4978-4982 Q05655 denotes PKCδ
T3379 5098-5102 Q05655 denotes PKCδ
T3380 5169-5173 Q05655 denotes PKCδ
T3381 5198-5207 P42574 denotes caspase-3
T3382 5440-5445 P09603 denotes M-CSF
T3383 5442-5445 P04141 denotes CSF
T3384 5509-5512 P31751 denotes AKT
T3385 5509-5512 P31749 denotes AKT
T3386 5509-5512 Q9Y243 denotes AKT
T3387 5541-5544 P31751 denotes AKT
T3388 5541-5544 Q9Y243 denotes AKT
T3389 5541-5544 P31749 denotes AKT
T3390 5557-5562 P09603 denotes M-CSF
T3391 5559-5562 P04141 denotes CSF
T3392 5695-5700 P09603 denotes M-CSF
T3393 5697-5700 P04141 denotes CSF
T3394 6078-6083 P09603 denotes M-CSF
T3395 6080-6083 P04141 denotes CSF
T3396 6137-6142 P09603 denotes M-CSF
T3397 6139-6142 P04141 denotes CSF
T3398 6325-6329 P17252 denotes PKCα
T3399 6344-6348 P17252 denotes PKCα
T3400 6454-6457 P21579 denotes p65
T3401 6454-6457 Q04206 denotes p65
T3402 6473-6478 P09603 denotes M-CSF
T3403 6475-6478 P04141 denotes CSF
T3404 6565-6569 P17252 denotes PKCα
T3405 6615-6618 P21579 denotes p65
T3406 6615-6618 Q04206 denotes p65

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue
T3407 1093-1100 Negative_regulation denotes lacking
T3408 2367-2382 Phosphorylation denotes phosphorylation
T3409 2506-2521 Phosphorylation denotes phosphorylation
T3410 2506-2521 Phosphorylation denotes phosphorylation
T3411 2506-2521 Phosphorylation denotes phosphorylation
T3412 2700-2714 Phosphorylation denotes phosphorylated
T3413 2858-2873 Phosphorylation denotes phosphorylation
T3414 2858-2873 Phosphorylation denotes phosphorylation
T3415 2903-2912 Regulation denotes regulated
T3416 2903-2912 Regulation denotes regulated
T3417 3023-3037 Phosphorylation denotes phosphorylated
T3418 1221-1225 Negative_regulation denotes null
T3419 3080-3093 Localization denotes translocation
T3420 3176-3191 Phosphorylation denotes phosphorylation
T3421 3275-3290 Phosphorylation denotes phosphorylation
T3422 3314-3316 Positive_regulation denotes by
T3423 3503-3514 Positive_regulation denotes stabilizing
T3424 3590-3604 Phosphorylation denotes phosphorylates
T3425 4621-4628 Positive_regulation denotes induces
T3426 4655-4665 Transcription denotes production
T3427 4621-4628 Positive_regulation denotes induces
T3428 4655-4665 Transcription denotes production
T3429 1293-1307 Gene_expression denotes overexpressing
T3430 4621-4628 Positive_regulation denotes induces
T3431 4655-4665 Transcription denotes production
T3432 4841-4854 Positive_regulation denotes overexpressed
T3433 4951-4961 Negative_regulation denotes inhibition
T3434 5183-5197 Phosphorylation denotes phosphorylates
T3435 6373-6382 Regulation denotes regulated
T3436 6419-6434 Phosphorylation denotes phosphorylation
T3437 6479-6488 Regulation denotes dependent
T3438 6570-6579 Regulation denotes regulated
T3439 6580-6595 Phosphorylation denotes phosphorylation
T3440 2044-2048 Positive_regulation denotes Upon
T3441 2099-2113 Phosphorylation denotes phosphorylated
T3442 2044-2048 Positive_regulation denotes Upon
T3443 2134-2142 Protein_catabolism denotes degraded
T3444 2240-2247 Localization denotes release
T3445 2281-2312 Protein_modification denotes post-translational modification
T3446 866-870 Protein denotes RelA
T3447 1029-1032 Protein denotes p65
T3448 6454-6457 Protein denotes p65
T3449 6615-6618 Protein denotes p65
T3450 6438-6444 Entity denotes Ser276
T3451 1107-1110 Protein denotes p65
T3452 6599-6605 Entity denotes Ser276
T3453 1217-1220 Protein denotes p65
T3454 1250-1254 Protein denotes TNFα
T3455 1318-1321 Protein denotes p65
T3456 1984-1987 Protein denotes p50
T3457 1988-1991 Protein denotes p65
T3458 2033-2037 Protein denotes IκBα
T3459 2091-2095 Protein denotes IκBα
T3460 2160-2163 Protein denotes p50
T3461 871-874 Protein denotes p65
T3462 2164-2167 Protein denotes p65
T3463 2253-2257 Protein denotes IκBα
T3464 2265-2268 Protein denotes p65
T3465 2363-2366 Protein denotes p65
T3466 2531-2534 Protein denotes p65
T3467 2693-2696 Protein denotes p65
T3468 2718-2722 Protein denotes MSK1
T3469 2948-2952 Protein denotes IKKβ
T3470 3001-3004 Protein denotes p65
T3471 3068-3071 Protein denotes p65
T3472 876-879 Protein denotes p50
T3473 3172-3175 Protein denotes p65
T3474 3310-3313 Protein denotes p65
T3475 3362-3366 Protein denotes p300
T3476 3515-3519 Protein denotes IκBα
T3477 3575-3580 Protein denotes Pim-1
T3478 3611-3614 Protein denotes p65
T3479 881-884 Protein denotes p52
T3480 2538-2544 Entity denotes Ser276
T3481 2546-2552 Entity denotes Ser529
T3482 886-891 Protein denotes c-Rel
T3483 2556-2562 Entity denotes Ser536
T3484 2677-2683 Entity denotes Ser276
T3485 2877-2883 Entity denotes Ser276
T3486 2888-2894 Entity denotes Ser536
T3487 3041-3047 Entity denotes Ser536
T3488 3072-3079 Entity denotes nuclear
T3489 896-900 Protein denotes RelB
T3490 3195-3201 Entity denotes Ser276
T3491 3294-3300 Entity denotes Ser276
T3492 3618-3624 Entity denotes Ser276
T3493 4209-4210 Protein denotes α
T3494 944-947 Protein denotes p50
T3495 4214-4217 Protein denotes βII
T3496 4222-4223 Protein denotes γ
T3497 4277-4278 Protein denotes δ
T3498 4280-4281 Protein denotes ε
T3499 4283-4284 Protein denotes η
T3500 4286-4287 Protein denotes θ
T3501 4292-4293 Protein denotes μ
T3502 4329-4330 Protein denotes ξ
T3503 4332-4333 Protein denotes ι
T3504 948-951 Protein denotes p65
T3505 4338-4339 Protein denotes λ
T3506 4446-4450 Protein denotes PKCα
T3507 4451-4456 Protein denotes PKCβI
T3508 4461-4467 Protein denotes PKCβII
T3509 4485-4489 Protein denotes PKCδ
T3510 4494-4498 Protein denotes PKCε
T3511 4616-4620 Protein denotes PKCα
T3512 4629-4634 Protein denotes IL-1α
T3513 4636-4640 Protein denotes iNOS
T3514 4645-4649 Protein denotes TNFα
T3515 1010-1013 Protein denotes p65
T3516 4784-4788 Protein denotes PKCα
T3517 4833-4837 Protein denotes PKCα
T3518 4965-4969 Protein denotes PKCα
T3519 4978-4982 Protein denotes PKCδ
T3520 5098-5102 Protein denotes PKCδ
T3521 5169-5173 Protein denotes PKCδ
T3522 5198-5207 Protein denotes caspase-3
T3523 5320-5324 Protein denotes PKCε
T3524 6307-6329 Protein denotes dominant negative PKCα
T3525 6344-6354 Protein denotes PKCα siRNA
T3526 162-198 Protein denotes Macrophage colony-stimulating factor
T3527 200-205 Protein denotes M-CSF
T3528 543-548 Protein denotes M-CSF
T3529 287-292 Protein denotes M-CSF
T3530 3848-3853 Protein denotes M-CSF
T3531 5440-5445 Protein denotes M-CSF
T3532 5557-5562 Protein denotes M-CSF
T3533 5695-5700 Protein denotes M-CSF
T3534 6078-6083 Protein denotes M-CSF
T3535 6137-6142 Protein denotes M-CSF
T3536 6473-6478 Protein denotes M-CSF
T3537 4211-4213 Protein denotes βI
R2924 T3413 T3415 themeOf phosphorylation,regulated
R2925 T3414 T3416 themeOf phosphorylation,regulated
R2926 T3421 T3422 themeOf phosphorylation,by
R2927 T3431 T3430 themeOf production,induces
R2928 T3435 T3437 themeOf regulated,dependent
R2929 T3436 T3435 themeOf phosphorylation,regulated
R2930 T3426 T3425 themeOf production,induces
R2931 T3439 T3438 themeOf phosphorylation,regulated
R2932 T3441 T3440 themeOf phosphorylated,Upon
R2933 T3443 T3442 themeOf degraded,Upon
R2934 T3428 T3427 themeOf production,induces
R2935 T3446 T3461 equivalentTo RelA,p65
R2936 T3483 T3411 themeOf Ser536,phosphorylation
R2937 T3450 T3436 themeOf Ser276,phosphorylation
R2938 T3450 T3448 partOf Ser276,p65
R2939 T3483 T3466 partOf Ser536,p65
R2940 T3451 T3407 themeOf p65,lacking
R2941 T3452 T3439 themeOf Ser276,phosphorylation
R2942 T3452 T3449 partOf Ser276,p65
R2943 T3484 T3412 themeOf Ser276,phosphorylated
R2944 T3453 T3418 themeOf p65,null
R2945 T3455 T3429 themeOf p65,overexpressing
R2946 T3484 T3467 partOf Ser276,p65
R2947 T3485 T3413 themeOf Ser276,phosphorylation
R2948 T3485 T3467 partOf Ser276,p65
R2949 T3459 T3443 themeOf IκBα,degraded
R2950 T3459 T3441 themeOf IκBα,phosphorylated
R2951 T3486 T3414 themeOf Ser536,phosphorylation
R2952 T3486 T3467 partOf Ser536,p65
R2953 T3487 T3417 themeOf Ser536,phosphorylated
R2954 T3464 T3444 themeOf p65,release
R2955 T3464 T3445 themeOf p65,post-translational modification
R2956 T3465 T3408 themeOf p65,phosphorylation
R2957 T3487 T3470 partOf Ser536,p65
R2958 T3488 T3419 locationOf nuclear,translocation
R2959 T3468 T3412 causeOf MSK1,phosphorylated
R2960 T3469 T3415 causeOf IKKβ,regulated
R2961 T3469 T3416 causeOf IKKβ,regulated
R2962 T3471 T3419 themeOf p65,translocation
R2963 T3490 T3420 themeOf Ser276,phosphorylation
R2964 T3490 T3473 partOf Ser276,p65
R2965 T3491 T3421 themeOf Ser276,phosphorylation
R2966 T3476 T3423 themeOf IκBα,stabilizing
R2967 T3477 T3424 causeOf Pim-1,phosphorylates
R2968 T3491 T3474 partOf Ser276,p65
R2969 T3492 T3424 themeOf Ser276,phosphorylates
R2970 T3480 T3409 themeOf Ser276,phosphorylation
R2971 T3480 T3466 partOf Ser276,p65
R2972 T3481 T3410 themeOf Ser529,phosphorylation
R2973 T3481 T3466 partOf Ser529,p65
R2974 T3492 T3478 partOf Ser276,p65
R2975 T3511 T3425 causeOf PKCα,induces
R2976 T3511 T3427 causeOf PKCα,induces
R2977 T3511 T3430 causeOf PKCα,induces
R2978 T3512 T3426 themeOf IL-1α,production
R2979 T3513 T3428 themeOf iNOS,production
R2980 T3514 T3431 themeOf TNFα,production
R2981 T3517 T3432 themeOf PKCα,overexpressed
R2982 T3518 T3433 themeOf PKCα,inhibition
R2983 T3521 T3434 causeOf PKCδ,phosphorylates
R2984 T3522 T3434 themeOf caspase-3,phosphorylates
R2985 T3527 T3526 equivalentTo M-CSF,Macrophage colony-stimulating factor
R2986 T3536 T3437 causeOf M-CSF,dependent

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T4393 162-198 Protein denotes Macrophage colony-stimulating factor
T4394 200-205 Protein denotes M-CSF
T4395 287-292 Protein denotes M-CSF
T4396 510-515 Protein denotes NF-κB
T4397 543-548 Protein denotes M-CSF
T4398 516-526 Positive_regulation denotes activation
T4399 664-669 Protein denotes NF-κB
T4400 852-864 Protein denotes NF-κB family
T4401 866-870 Protein denotes RelA
T4402 871-874 Protein denotes p65
T4403 876-879 Protein denotes p50
T4404 881-884 Protein denotes p52
T4405 886-891 Protein denotes c-Rel
T4406 896-900 Protein denotes RelB
T4407 944-947 Protein denotes p50
T4408 948-951 Protein denotes p65
T4409 1004-1009 Protein denotes NF-κB
T4410 1010-1021 Protein denotes p65 subunit
T4411 990-996 Entity denotes domain
T4412 1023-1028 Protein denotes NF-κB
T4413 1029-1032 Protein denotes p65
T4414 1101-1110 Protein denotes NF-κB p65
T4415 1093-1100 Negative_regulation denotes lacking
T4416 1211-1216 Protein denotes NF-κB
T4417 1217-1220 Protein denotes p65
T4418 1250-1254 Protein denotes TNFα
T4419 1312-1329 Protein denotes NF-κB p65 subunit
T4420 1293-1307 Gene_expression denotes overexpressing
T4421 1357-1362 Protein denotes NF-κB
T4422 1472-1477 Protein denotes NF-κB
T4423 1536-1541 Protein denotes NF-κB
T4424 1585-1595 Gene_expression denotes expression
T4425 1675-1680 Protein denotes NF-κB
T4426 1885-1890 Protein denotes NF-κB
T4427 1978-1983 Protein denotes NF-κB
T4428 1984-1987 Protein denotes p50
T4429 1988-1991 Protein denotes p65
T4430 2033-2042 Protein denotes IκBα [15]
T4431 2091-2095 Protein denotes IκBα
T4432 2154-2159 Protein denotes NF-κB
T4433 2160-2163 Protein denotes p50
T4434 2164-2167 Protein denotes p65
T4435 2099-2113 Phosphorylation denotes phosphorylated
T4436 2134-2142 Protein_catabolism denotes degraded
T4437 2144-2153 Localization denotes releasing
T4438 2144-2153 Localization denotes releasing
T4439 2144-2153 Localization denotes releasing
T4440 2190-2197 Entity denotes nucleus
T4441 2171-2182 Localization denotes translocate
T4442 2171-2182 Localization denotes translocate
T4443 2171-2182 Localization denotes translocate
T4444 2253-2257 Protein denotes IκBα
T4445 2259-2264 Protein denotes NF-κB
T4446 2265-2268 Protein denotes p65
T4447 2357-2362 Protein denotes NF-κB
T4448 2363-2366 Protein denotes p65
T4449 2386-2391 Protein denotes NF-κB
T4450 2367-2382 Phosphorylation denotes phosphorylation
T4451 2367-2382 Phosphorylation denotes phosphorylation
T4452 2349-2353 Regulation denotes role
T4453 2349-2353 Regulation denotes role
T4454 2525-2534 Protein denotes NF-κB p65
T4455 2629-2634 Protein denotes NF-κB
T4456 2506-2521 Phosphorylation denotes phosphorylation
T4457 2644-2648 Protein denotes TNFα
T4458 2687-2696 Protein denotes NF-κB p65
T4459 2718-2722 Protein denotes MSK1
T4460 2734-2739 Protein denotes NF-κB
T4461 2700-2714 Phosphorylation denotes phosphorylated
T4462 2726-2733 Positive_regulation denotes enhance
T4463 2810-2815 Protein denotes NF-κB
T4464 2921-2937 Protein denotes protein kinase A
T4465 2939-2942 Protein denotes PKA
T4466 2948-2952 Protein denotes IKKβ
T4467 2842-2852 Binding denotes associated
T4468 2995-3004 Protein denotes NF-κB p65
T4469 3062-3067 Protein denotes NF-κB
T4470 3068-3071 Protein denotes p65
T4471 3041-3047 Entity denotes Ser536
T4472 3072-3079 Entity denotes nuclear
T4473 3080-3093 Localization denotes translocation
T4474 3080-3093 Localization denotes translocation
T4475 3023-3037 Phosphorylation denotes phosphorylated
T4476 3051-3061 Positive_regulation denotes facilitate
T4477 3051-3061 Positive_regulation denotes facilitate
T4478 3166-3171 Protein denotes NF-κB
T4479 3172-3175 Protein denotes p65
T4480 3176-3191 Phosphorylation denotes phosphorylation
T4481 3176-3191 Phosphorylation denotes phosphorylation
T4482 3205-3212 Positive_regulation denotes crucial
T4483 3205-3212 Positive_regulation denotes crucial
T4484 3304-3309 Protein denotes NF-κB
T4485 3310-3313 Protein denotes p65
T4486 3317-3320 Protein denotes PKA
T4487 3362-3366 Protein denotes p300
T4488 3381-3386 Protein denotes NF-κB
T4489 3252-3259 Entity denotes nuclear
T4490 3294-3300 Entity denotes Ser276
T4491 3275-3290 Phosphorylation denotes phosphorylation
T4492 3275-3290 Phosphorylation denotes phosphorylation
T4493 3275-3290 Phosphorylation denotes phosphorylation
T4494 3455-3458 Protein denotes PKA
T4495 3468-3473 Protein denotes NF-κB
T4496 3551-3574 Protein denotes serine/threonine kinase
T4497 3575-3580 Protein denotes Pim-1
T4498 3605-3614 Protein denotes NF-κB p65
T4499 3651-3660 Protein denotes ubiquitin
T4500 3672-3683 Protein_catabolism denotes degradation
T4501 3756-3761 Protein denotes NF-κB
T4502 3748-3755 Positive_regulation denotes enhance
T4503 3822-3838 Protein denotes protein kinase C
T4504 3840-3843 Protein denotes PKC
T4505 3848-3853 Protein denotes M-CSF
T4506 3865-3870 Protein denotes NF-κB
T4507 3883-3895 Protein denotes PKC proteins
T4508 3991-3995 Protein denotes PKCs
T4509 4145-4155 Protein denotes PKC family
T4510 4209-4217 Protein denotes α βI βII
T4511 4461-4467 Protein denotes PKCβII
T4512 4411-4418 Gene_expression denotes express
T4513 4616-4620 Protein denotes PKCα
T4514 4629-4634 Protein denotes IL-1α
T4515 4636-4640 Protein denotes iNOS
T4516 4645-4654 Protein denotes TNFα mRNA
T4517 4655-4665 Gene_expression denotes production
T4518 4655-4665 Gene_expression denotes production
T4519 4655-4665 Gene_expression denotes production
T4520 4621-4628 Positive_regulation denotes induces
T4521 4621-4628 Positive_regulation denotes induces
T4522 4621-4628 Positive_regulation denotes induces
T4523 4774-4788 Protein denotes PKCs like PKCα
T4524 4833-4837 Protein denotes PKCα
T4525 4841-4854 Gene_expression denotes overexpressed
T4526 4841-4854 Positive_regulation denotes overexpressed
T4527 4965-4982 Protein denotes PKCα induces PKCδ
T4528 5088-5102 Protein denotes PKCs like PKCδ
T4529 5169-5173 Protein denotes PKCδ
T4530 5198-5207 Protein denotes caspase-3
T4531 5183-5197 Phosphorylation denotes phosphorylates
T4532 5183-5197 Phosphorylation denotes phosphorylates
T4533 5315-5318 Protein denotes PKC
T4534 5320-5324 Protein denotes PKCε
T4535 5440-5445 Protein denotes M-CSF
T4536 5503-5508 Protein denotes PI3-K
T4537 5509-5512 Protein denotes AKT
T4538 5485-5495 Positive_regulation denotes activation
T4539 5485-5495 Positive_regulation denotes activation
T4540 5541-5544 Protein denotes AKT
T4541 5557-5562 Protein denotes M-CSF
T4542 5574-5577 Protein denotes PKC
T4543 5611-5616 Protein denotes NF-κB
T4544 5545-5555 Positive_regulation denotes activation
T4545 5563-5573 Positive_regulation denotes stimulates
T4546 5563-5573 Positive_regulation denotes stimulates
T4547 5621-5628 Binding denotes binding
T4548 5601-5610 Positive_regulation denotes increases
T4549 5652-5655 Protein denotes PKC
T4550 5663-5668 Protein denotes NF-κB
T4551 5695-5700 Protein denotes M-CSF
T4552 5669-5679 Positive_regulation denotes activation
T4553 5669-5679 Positive_regulation denotes activation
T4554 5794-5797 Protein denotes PKC
T4555 5825-5830 Protein denotes NF-κB
T4556 6032-6035 Protein denotes PKC
T4557 6057-6062 Protein denotes NF-κB
T4558 6078-6083 Protein denotes M-CSF
T4559 6063-6073 Positive_regulation denotes activation
T4560 6043-6053 Regulation denotes regulation
T4561 6024-6028 Regulation denotes role
T4562 6137-6142 Protein denotes M-CSF
T4563 6159-6164 Protein denotes NF-κB
T4564 6165-6178 Transcription denotes transcription
T4565 6143-6154 Positive_regulation denotes upregulated
T4566 6291-6294 Protein denotes PKC
T4567 6325-6329 Protein denotes PKCα
T4568 6344-6354 Protein denotes PKCα siRNA
T4569 6369-6372 Protein denotes PKC
T4570 6383-6388 Protein denotes NF-κB
T4571 6448-6457 Protein denotes NF-κB p65
T4572 6473-6478 Protein denotes M-CSF
T4573 6419-6434 Phosphorylation denotes phosphorylation
T4574 6438-6444 Positive_regulation denotes Ser276
T4575 6438-6444 Positive_regulation denotes Ser276
T4576 6458-6466 Positive_regulation denotes occurred
T4577 6565-6569 Protein denotes PKCα
T4578 6609-6614 Protein denotes NF-κB
T4579 6615-6618 Protein denotes p65
T4580 6599-6605 Entity denotes Ser276
T4581 6580-6595 Phosphorylation denotes phosphorylation
T4582 6580-6595 Phosphorylation denotes phosphorylation
T4583 6570-6579 Regulation denotes regulated
T4584 6570-6579 Regulation denotes regulated
R3328 T4460 T4462 themeOf NF-κB,enhance
R3329 T4463 T4467 themeOf NF-κB,associated
R3330 T4396 T4398 themeOf NF-κB,activation
R3331 T4468 T4475 themeOf NF-κB p65,phosphorylated
R3332 T4468 T4476 causeOf NF-κB p65,facilitate
R3333 T4468 T4477 causeOf NF-κB p65,facilitate
R3334 T4469 T4473 themeOf NF-κB,translocation
R3335 T4409 T4411 partOf NF-κB,domain
R3336 T4410 T4411 partOf p65 subunit,domain
R3337 T4470 T4474 themeOf p65,translocation
R3338 T4471 T4475 Site Ser536,phosphorylated
R3339 T4414 T4415 themeOf NF-κB p65,lacking
R3340 T4472 T4473 locationOf nuclear,translocation
R3341 T4472 T4474 locationOf nuclear,translocation
R3342 T4419 T4420 themeOf NF-κB p65 subunit,overexpressing
R3343 T4473 T4476 themeOf translocation,facilitate
R3344 T4423 T4424 themeOf NF-κB,expression
R3345 T4474 T4477 themeOf translocation,facilitate
R3346 T4478 T4480 themeOf NF-κB,phosphorylation
R3347 T4431 T4435 themeOf IκBα,phosphorylated
R3348 T4431 T4436 themeOf IκBα,degraded
R3349 T4432 T4437 themeOf NF-κB,releasing
R3350 T4432 T4441 themeOf NF-κB,translocate
R3351 T4433 T4438 themeOf p50,releasing
R3352 T4433 T4442 themeOf p50,translocate
R3353 T4479 T4481 themeOf p65,phosphorylation
R3354 T4434 T4439 themeOf p65,releasing
R3355 T4434 T4443 themeOf p65,translocate
R3356 T4480 T4482 themeOf phosphorylation,crucial
R3357 T4481 T4483 themeOf phosphorylation,crucial
R3358 T4440 T4441 locationOf nucleus,translocate
R3359 T4440 T4442 locationOf nucleus,translocate
R3360 T4440 T4443 locationOf nucleus,translocate
R3361 T4484 T4491 themeOf NF-κB,phosphorylation
R3362 T4485 T4492 themeOf p65,phosphorylation
R3363 T4447 T4450 themeOf NF-κB,phosphorylation
R3364 T4448 T4451 themeOf p65,phosphorylation
R3365 T4485 T4490 partOf p65,Ser276
R3366 T4450 T4452 themeOf phosphorylation,role
R3367 T4486 T4493 themeOf PKA,phosphorylation
R3368 T4451 T4453 themeOf phosphorylation,role
R3369 T4486 T4490 partOf PKA,Ser276
R3370 T4454 T4456 themeOf NF-κB p65,phosphorylation
R3371 T4490 T4491 Site Ser276,phosphorylation
R3372 T4458 T4461 themeOf NF-κB p65,phosphorylated
R3373 T4490 T4492 Site Ser276,phosphorylation
R3374 T4490 T4493 Site Ser276,phosphorylation
R3375 T4499 T4500 themeOf ubiquitin,degradation
R3376 T4529 T4531 themeOf PKCδ,phosphorylates
R3377 T4530 T4532 themeOf caspase-3,phosphorylates
R3378 T4501 T4502 themeOf NF-κB,enhance
R3379 T4535 T4538 causeOf M-CSF,activation
R3380 T4535 T4539 causeOf M-CSF,activation
R3381 T4536 T4538 themeOf PI3-K,activation
R3382 T4537 T4539 themeOf AKT,activation
R3383 T4511 T4512 themeOf PKCβII,express
R3384 T4540 T4544 themeOf AKT,activation
R3385 T4541 T4545 causeOf M-CSF,stimulates
R3386 T4541 T4546 causeOf M-CSF,stimulates
R3387 T4541 T4548 causeOf M-CSF,increases
R3388 T4542 T4545 themeOf PKC,stimulates
R3389 T4543 T4547 themeOf NF-κB,binding
R3390 T4544 T4546 themeOf activation,stimulates
R3391 T4547 T4548 themeOf binding,increases
R3392 T4549 T4552 themeOf PKC,activation
R3393 T4550 T4553 themeOf NF-κB,activation
R3394 T4513 T4520 causeOf PKCα,induces
R3395 T4556 T4561 causeOf PKC,role
R3396 T4557 T4559 themeOf NF-κB,activation
R3397 T4559 T4560 themeOf activation,regulation
R3398 T4513 T4521 causeOf PKCα,induces
R3399 T4560 T4561 themeOf regulation,role
R3400 T4513 T4522 causeOf PKCα,induces
R3401 T4514 T4517 themeOf IL-1α,production
R3402 T4562 T4565 causeOf M-CSF,upregulated
R3403 T4563 T4564 themeOf NF-κB,transcription
R3404 T4564 T4565 themeOf transcription,upregulated
R3405 T4515 T4518 themeOf iNOS,production
R3406 T4516 T4519 themeOf TNFα mRNA,production
R3407 T4517 T4520 themeOf production,induces
R3408 T4571 T4573 themeOf NF-κB p65,phosphorylation
R3409 T4518 T4521 themeOf production,induces
R3410 T4571 T4574 themeOf NF-κB p65,Ser276
R3411 T4519 T4522 themeOf production,induces
R3412 T4573 T4575 themeOf phosphorylation,Ser276
R3413 T4573 T4576 themeOf phosphorylation,occurred
R3414 T4524 T4525 themeOf PKCα,overexpressed
R3415 T4577 T4583 causeOf PKCα,regulated
R3416 T4577 T4584 causeOf PKCα,regulated
R3417 T4578 T4581 themeOf NF-κB,phosphorylation
R3418 T4578 T4580 partOf NF-κB,Ser276
R3419 T4579 T4582 themeOf p65,phosphorylation
R3420 T4579 T4580 partOf p65,Ser276
R3421 T4580 T4581 Site Ser276,phosphorylation
R3422 T4580 T4582 Site Ser276,phosphorylation
R3423 T4581 T4583 themeOf phosphorylation,regulated
R3424 T4525 T4526 themeOf overexpressed,overexpressed
R3425 T4582 T4584 themeOf phosphorylation,regulated

events-check-again

Id Subject Object Predicate Lexical cue
T4262 162-198 Protein denotes Macrophage colony-stimulating factor
T4263 200-205 Protein denotes M-CSF
T4264 287-292 Protein denotes M-CSF
T4265 543-548 Protein denotes M-CSF
T4266 866-870 Protein denotes RelA
T4267 871-874 Protein denotes p65
T4268 876-879 Protein denotes p50
T4269 881-884 Protein denotes p52
T4270 886-891 Protein denotes c-Rel
T4271 896-900 Protein denotes RelB
T4272 944-947 Protein denotes p50
T4273 948-951 Protein denotes p65
T4274 1010-1013 Protein denotes p65
T4275 1029-1032 Protein denotes p65
T4276 1093-1100 Negative_regulation denotes lacking
T4277 1107-1110 Protein denotes p65
T4278 1217-1220 Protein denotes p65
T4279 1221-1225 Negative_regulation denotes null
T4280 1250-1254 Protein denotes TNFα
T4281 1293-1307 Gene_expression denotes overexpressing
T4282 1318-1321 Protein denotes p65
T4283 1984-1987 Protein denotes p50
T4284 1988-1991 Protein denotes p65
T4285 2033-2037 Protein denotes IκBα
T4286 2044-2048 Positive_regulation denotes Upon
T4287 2044-2048 Positive_regulation denotes Upon
T4288 2091-2095 Protein denotes IκBα
T4289 2099-2113 Phosphorylation denotes phosphorylated
T4290 2134-2142 Protein_catabolism denotes degraded
T4291 2160-2163 Protein denotes p50
T4292 2164-2167 Protein denotes p65
T4293 2240-2247 Localization denotes release
T4294 2253-2257 Protein denotes IκBα
T4295 2265-2268 Protein denotes p65
T4296 2281-2312 Protein_modification denotes post-translational modification
T4297 2363-2366 Protein denotes p65
T4298 2367-2382 Phosphorylation denotes phosphorylation
T4299 2506-2521 Phosphorylation denotes phosphorylation
T4300 2506-2521 Phosphorylation denotes phosphorylation
T4301 2506-2521 Phosphorylation denotes phosphorylation
T4302 2531-2534 Protein denotes p65
T4303 2538-2544 Entity denotes Ser276
T4304 2546-2552 Entity denotes Ser529
T4305 2556-2562 Entity denotes Ser536
T4306 2677-2683 Entity denotes Ser276
T4307 2693-2696 Protein denotes p65
T4308 2700-2714 Phosphorylation denotes phosphorylated
T4309 2718-2722 Protein denotes MSK1
T4310 2858-2873 Phosphorylation denotes phosphorylation
T4311 2858-2873 Phosphorylation denotes phosphorylation
T4312 2877-2883 Entity denotes Ser276
T4313 2888-2894 Entity denotes Ser536
T4314 2903-2912 Regulation denotes regulated
T4315 2903-2912 Regulation denotes regulated
T4316 2948-2952 Protein denotes IKKβ
T4317 3001-3004 Protein denotes p65
T4318 3023-3037 Phosphorylation denotes phosphorylated
T4319 3041-3047 Entity denotes Ser536
T4320 3068-3071 Protein denotes p65
T4321 3072-3079 Entity denotes nuclear
T4322 3080-3093 Localization denotes translocation
T4323 3172-3175 Protein denotes p65
T4324 3176-3191 Phosphorylation denotes phosphorylation
T4325 3195-3201 Entity denotes Ser276
T4326 3275-3290 Phosphorylation denotes phosphorylation
T4327 3294-3300 Entity denotes Ser276
T4328 3310-3313 Protein denotes p65
T4329 3314-3316 Positive_regulation denotes by
T4330 3362-3366 Protein denotes p300
T4331 3503-3514 Positive_regulation denotes stabilizing
T4332 3515-3519 Protein denotes IκBα
T4333 3575-3580 Protein denotes Pim-1
T4334 3590-3604 Phosphorylation denotes phosphorylates
T4335 3611-3614 Protein denotes p65
T4336 3618-3624 Entity denotes Ser276
T4337 3848-3853 Protein denotes M-CSF
T4338 4209-4210 Protein denotes α
T4339 4211-4213 Protein denotes βI
T4340 4214-4217 Protein denotes βII
T4341 4222-4223 Protein denotes γ
T4342 4277-4278 Protein denotes δ
T4343 4280-4281 Protein denotes ε
T4344 4283-4284 Protein denotes η
T4345 4286-4287 Protein denotes θ
T4346 4292-4293 Protein denotes μ
T4347 4329-4330 Protein denotes ξ
T4348 4332-4333 Protein denotes ι
T4349 4338-4339 Protein denotes λ
T4350 4446-4450 Protein denotes PKCα
T4351 4451-4456 Protein denotes PKCβI
T4352 4461-4467 Protein denotes PKCβII
T4353 4485-4489 Protein denotes PKCδ
T4354 4494-4498 Protein denotes PKCε
T4355 4616-4620 Protein denotes PKCα
T4356 4621-4628 Positive_regulation denotes induces
T4357 4621-4628 Positive_regulation denotes induces
T4358 4621-4628 Positive_regulation denotes induces
T4359 4629-4634 Protein denotes IL-1α
T4360 4636-4640 Protein denotes iNOS
T4361 4645-4649 Protein denotes TNFα
T4362 4655-4665 Transcription denotes production
T4363 4655-4665 Transcription denotes production
T4364 4655-4665 Transcription denotes production
T4365 4784-4788 Protein denotes PKCα
T4366 4833-4837 Protein denotes PKCα
T4367 4841-4854 Positive_regulation denotes overexpressed
T4368 4951-4961 Negative_regulation denotes inhibition
T4369 4965-4969 Protein denotes PKCα
T4370 4978-4982 Protein denotes PKCδ
T4371 5098-5102 Protein denotes PKCδ
T4372 5169-5173 Protein denotes PKCδ
T4373 5183-5197 Phosphorylation denotes phosphorylates
T4374 5198-5207 Protein denotes caspase-3
T4375 5320-5324 Protein denotes PKCε
T4376 5440-5445 Protein denotes M-CSF
T4377 5557-5562 Protein denotes M-CSF
T4378 5695-5700 Protein denotes M-CSF
T4379 6078-6083 Protein denotes M-CSF
T4380 6137-6142 Protein denotes M-CSF
T4381 6307-6329 Protein denotes dominant negative PKCα
T4382 6344-6354 Protein denotes PKCα siRNA
T4383 6373-6382 Regulation denotes regulated
T4384 6419-6434 Phosphorylation denotes phosphorylation
T4385 6438-6444 Entity denotes Ser276
T4386 6454-6457 Protein denotes p65
T4387 6473-6478 Protein denotes M-CSF
T4388 6479-6488 Regulation denotes dependent
T4389 6570-6579 Regulation denotes regulated
T4390 6580-6595 Phosphorylation denotes phosphorylation
T4391 6599-6605 Entity denotes Ser276
T4392 6615-6618 Protein denotes p65
R3218 T4263 T4262 equivalentTo M-CSF,Macrophage colony-stimulating factor
R3219 T4266 T4267 equivalentTo RelA,p65
R3228 T4277 T4276 themeOf p65,lacking
R3245 T4278 T4279 themeOf p65,null
R3248 T4282 T4281 themeOf p65,overexpressing
R3251 T4288 T4290 themeOf IκBα,degraded
R3254 T4288 T4289 themeOf IκBα,phosphorylated
R3255 T4289 T4286 themeOf phosphorylated,Upon
R3256 T4290 T4287 themeOf degraded,Upon
R3257 T4295 T4293 themeOf p65,release
R3261 T4295 T4296 themeOf p65,post-translational modification
R3262 T4297 T4298 themeOf p65,phosphorylation
R3266 T4303 T4299 themeOf Ser276,phosphorylation
R3272 T4303 T4302 partOf Ser276,p65
R3273 T4304 T4300 themeOf Ser529,phosphorylation
R3275 T4304 T4302 partOf Ser529,p65
R3277 T4305 T4301 themeOf Ser536,phosphorylation
R3278 T4305 T4302 partOf Ser536,p65
R3279 T4306 T4308 themeOf Ser276,phosphorylated
R3280 T4306 T4307 partOf Ser276,p65
R3281 T4309 T4308 causeOf MSK1,phosphorylated
R3286 T4310 T4314 themeOf phosphorylation,regulated
R3287 T4311 T4315 themeOf phosphorylation,regulated
R3288 T4312 T4310 themeOf Ser276,phosphorylation
R3289 T4312 T4307 partOf Ser276,p65
R3290 T4313 T4311 themeOf Ser536,phosphorylation
R3291 T4313 T4307 partOf Ser536,p65
R3292 T4316 T4314 causeOf IKKβ,regulated
R3293 T4355 T4356 causeOf PKCα,induces
R3294 T4355 T4357 causeOf PKCα,induces
R3295 T4355 T4358 causeOf PKCα,induces
R3296 T4316 T4315 causeOf IKKβ,regulated
R3297 T4319 T4318 themeOf Ser536,phosphorylated
R3298 T4359 T4362 themeOf IL-1α,production
R3299 T4360 T4363 themeOf iNOS,production
R3300 T4361 T4364 themeOf TNFα,production
R3301 T4362 T4356 themeOf production,induces
R3302 T4363 T4357 themeOf production,induces
R3303 T4319 T4317 partOf Ser536,p65
R3304 T4364 T4358 themeOf production,induces
R3305 T4320 T4322 themeOf p65,translocation
R3306 T4366 T4367 themeOf PKCα,overexpressed
R3307 T4321 T4322 locationOf nuclear,translocation
R3308 T4369 T4368 themeOf PKCα,inhibition
R3309 T4325 T4324 themeOf Ser276,phosphorylation
R3310 T4372 T4373 causeOf PKCδ,phosphorylates
R3311 T4374 T4373 themeOf caspase-3,phosphorylates
R3312 T4325 T4323 partOf Ser276,p65
R3313 T4326 T4329 themeOf phosphorylation,by
R3314 T4327 T4326 themeOf Ser276,phosphorylation
R3315 T4327 T4328 partOf Ser276,p65
R3316 T4383 T4388 themeOf regulated,dependent
R3317 T4332 T4331 themeOf IκBα,stabilizing
R3318 T4384 T4383 themeOf phosphorylation,regulated
R3319 T4385 T4384 themeOf Ser276,phosphorylation
R3320 T4385 T4386 partOf Ser276,p65
R3321 T4387 T4388 causeOf M-CSF,dependent
R3322 T4333 T4334 causeOf Pim-1,phosphorylates
R3323 T4336 T4334 themeOf Ser276,phosphorylates
R3324 T4390 T4389 themeOf phosphorylation,regulated
R3325 T4391 T4390 themeOf Ser276,phosphorylation
R3326 T4391 T4392 partOf Ser276,p65
R3327 T4336 T4335 partOf Ser276,p65

ICD10

Id Subject Object Predicate Lexical cue
T3588 389-404 http://purl.bioontology.org/ontology/ICD10/I70 denotes atherosclerosis

GO-CC

Id Subject Object Predicate Lexical cue
T3618 302-306 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3619 761-765 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3620 1371-1375 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3621 1390-1394 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3622 1613-1617 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3623 1756-1760 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3624 2461-2465 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3625 4020-4024 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3626 4046-4050 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3627 4580-4584 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3628 5131-5135 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3629 5846-5850 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3630 6183-6187 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3631 1613-1625 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface
T3632 2022-2029 http://purl.obolibrary.org/obo/GO_0005829 denotes cytosol
T3633 2190-2197 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T3634 2939-2942 http://purl.obolibrary.org/obo/GO_0005952 denotes PKA
T3635 3317-3320 http://purl.obolibrary.org/obo/GO_0005952 denotes PKA
T3636 3455-3458 http://purl.obolibrary.org/obo/GO_0005952 denotes PKA
T3637 3661-3671 http://purl.obolibrary.org/obo/GO_0000502 denotes proteasome

GO-MF

Id Subject Object Predicate Lexical cue
T3589 2939-2942 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA
T3590 3317-3320 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA
T3591 3455-3458 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA
T3592 3334-3360 http://purl.obolibrary.org/obo/GO_0003713 denotes transcription co-activator
T3593 3651-3660 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T3594 3840-3843 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T3595 3883-3886 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T3596 4145-4148 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T3597 4432-4435 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T3598 5315-5318 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T3599 5574-5577 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T3600 5652-5655 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T3601 5794-5797 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T3602 6032-6035 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T3603 6291-6294 http://purl.obolibrary.org/obo/GO_0004697 denotes PKC
T3604 4446-4450 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T3605 4616-4620 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T3606 4784-4788 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T3607 4833-4837 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T3608 4965-4969 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T3609 6325-6329 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T3610 6344-6348 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCα
T3611 4485-4489 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCδ
T3612 4978-4982 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCδ
T3613 5098-5102 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCδ
T3614 4494-4498 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCε
T3615 5320-5324 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCε
T3616 5617-5628 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T3617 5621-5628 http://purl.obolibrary.org/obo/GO_0005488 denotes binding

GO-BP

Id Subject Object Predicate Lexical cue
T4585 142-151 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T4586 5239-5248 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T4587 643-656 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T4588 2330-2343 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T4589 2816-2829 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T4590 3334-3347 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T4591 3402-3415 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T4592 6165-6178 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T4593 6526-6541 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T4594 724-732 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T4595 3104-3112 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T4596 1169-1178 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T4597 5947-5955 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T4598 733-742 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T4599 5370-5379 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T4600 744-759 http://purl.obolibrary.org/obo/GO_0006950 denotes stress response
T4601 761-772 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T4602 4046-4057 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T4603 766-772 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T4604 4051-4057 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T4605 804-816 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T4606 1053-1076 http://purl.obolibrary.org/obo/GO_0032502 denotes developmental processes
T4607 1263-1272 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T4608 4089-4100 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T4609 1346-1362 http://purl.obolibrary.org/obo/GO_0032088 denotes inhibiting NF-κB
T4610 3459-3473 http://purl.obolibrary.org/obo/GO_0032088 denotes inhibits NF-κB
T4611 1346-1362 http://purl.obolibrary.org/obo/GO_0007252 denotes inhibiting NF-κB
T4612 3459-3473 http://purl.obolibrary.org/obo/GO_0007252 denotes inhibits NF-κB
T4613 1371-1381 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T4614 1376-1381 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T4615 1913-1921 http://purl.obolibrary.org/obo/GO_0048286 denotes alveolar
T4616 2003-2014 http://purl.obolibrary.org/obo/GO_0051235 denotes sequestered
T4617 2134-2142 http://purl.obolibrary.org/obo/GO_0009056 denotes degraded
T4618 4993-5002 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T4619 3672-3683 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T4620 2281-2312 http://purl.obolibrary.org/obo/GO_0043687 denotes post-translational modification
T4621 2281-2312 http://purl.obolibrary.org/obo/GO_1901873 denotes post-translational modification
T4622 2281-2312 http://purl.obolibrary.org/obo/GO_1901874 denotes post-translational modification
T4623 2367-2382 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T4624 2506-2521 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T4625 2858-2873 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T4626 3176-3191 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T4627 3275-3290 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T4628 5239-5248 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T4629 3704-3719 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T4630 6419-6434 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T4631 6580-6595 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T4632 2939-2942 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA
T4633 3317-3320 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA
T4634 3455-3458 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA
T4635 3334-3360 http://purl.obolibrary.org/obo/GO_0003713 denotes transcription co-activator
T4636 3484-3499 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T4637 6399-6414 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T4638 3661-3683 http://purl.obolibrary.org/obo/GO_1903009 denotes proteasome degradation
T4639 142-151 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T4640 3767-3782 http://purl.obolibrary.org/obo/GO_2000144 denotes transactivation
T4641 1169-1178 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T4642 1263-1272 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T4643 5361-5392 http://purl.obolibrary.org/obo/GO_1900171 denotes mediated signaling in activated
T4644 5361-5392 http://purl.obolibrary.org/obo/GO_0050850 denotes mediated signaling in activated
T4645 5361-5392 http://purl.obolibrary.org/obo/GO_1900459 denotes mediated signaling in activated
T4646 4993-5002 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T4647 5361-5392 http://purl.obolibrary.org/obo/GO_1902661 denotes mediated signaling in activated
T4648 6032-6053 http://purl.obolibrary.org/obo/GO_1900019 denotes PKC in the regulation
T4649 6043-6053 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation

UBERON-AE

Id Subject Object Predicate Lexical cue
T960 43-54 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
T961 72-77 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T962 117-122 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T963 440-446 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
T964 1133-1142 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensive
T965 1143-1148 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T966 4902-4907 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T967 4913-4917 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T3306 2895-2899 Anaphor denotes that
T3307 2858-2873 Antecedent denotes phosphorylation
T3304 2236-2239 Anaphor denotes its
T3305 2265-2268 Antecedent denotes p65
R2878 T3304 T3305 boundBy its,p65
R2880 T3306 T3307 boundBy that,phosphorylation

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T2187 13-22 NN denotes Monocytes
T2188 23-26 VB denotes are
T2189 27-35 VB denotes produced
T2190 36-38 IN denotes in
T2191 39-42 DT denotes the
T2192 43-47 NN denotes bone
T2193 48-54 NN denotes marrow
T2194 55-58 CC denotes and
T2195 59-68 VB denotes circulate
T2196 69-71 IN denotes in
T2197 72-77 NN denotes blood
T2198 78-81 IN denotes for
T2199 82-87 CD denotes 24–48
T2200 88-93 NN denotes hours
T2201 94-95 -LRB- denotes [
T2202 95-96 CD denotes 1
T2203 96-97 -RRB- denotes ]
T2204 99-101 IN denotes In
T2205 102-105 DT denotes the
T2206 106-113 NN denotes absence
T2207 114-116 IN denotes of
T2208 117-122 NN denotes serum
T2209 122-123 -COMMA- denotes ,
T2210 124-133 NN denotes monocytes
T2211 134-137 VB denotes die
T2212 138-141 IN denotes via
T2213 142-151 NN denotes apoptosis
T2214 152-153 -LRB- denotes [
T2215 153-154 CD denotes 1
T2216 154-155 -RRB- denotes ]
T2217 155-156 -COMMA- denotes ,
T2218 157-158 -LRB- denotes [
T2219 158-159 CD denotes 2
T2220 159-160 -RRB- denotes ]
T2221 162-172 NN denotes Macrophage
T2222 173-191 JJ denotes colony-stimulating
T2223 192-198 NN denotes factor
T2224 199-200 -LRB- denotes (
T2225 200-205 NN denotes M-CSF
T2226 205-206 -RRB- denotes )
T2227 207-217 VB denotes stimulates
T2228 218-229 JJ denotes mononuclear
T2229 230-239 NN denotes phagocyte
T2230 240-248 NN denotes survival
T2231 249-252 CC denotes and
T2232 253-268 NN denotes differentiation
T2233 269-270 -LRB- denotes [
T2234 270-271 CD denotes 3
T2235 271-272 -RRB- denotes ]
T2236 274-285 RB denotes Importantly
T2237 285-286 -COMMA- denotes ,
T2238 287-301 JJ denotes M-CSF-mediated
T2239 302-306 NN denotes cell
T2240 307-315 NN denotes survival
T2241 316-319 CC denotes and
T2242 320-330 NN denotes activation
T2243 331-333 VB denotes is
T2244 334-344 VB denotes associated
T2245 345-349 IN denotes with
T2246 350-351 DT denotes a
T2247 352-359 NN denotes variety
T2248 360-362 IN denotes of
T2249 363-368 JJ denotes human
T2250 369-377 NN denotes diseases
T2251 377-378 -COMMA- denotes ,
T2252 379-388 VB denotes including
T2253 389-404 NN denotes atherosclerosis
T2254 404-405 -COMMA- denotes ,
T2255 406-416 NN denotes transplant
T2256 417-425 JJ denotes vascular
T2257 426-435 NN denotes sclerosis
T2258 436-439 CC denotes and
T2259 440-446 NN denotes breast
T2260 447-453 NN denotes cancer
T2261 454-464 NN denotes metastasis
T2262 465-466 -LRB- denotes [
T2263 466-467 CD denotes 4
T2264 467-468 -RRB- denotes ]
T2265 468-469 -COMMA- denotes ,
T2266 470-471 -LRB- denotes [
T2267 471-472 CD denotes 5
T2268 472-473 -RRB- denotes ]
T2269 473-474 -COMMA- denotes ,
T2270 475-476 -LRB- denotes [
T2271 476-477 CD denotes 6
T2272 477-478 -RRB- denotes ]
T2273 480-482 PRP denotes We
T2274 483-493 RB denotes previously
T2275 494-504 VB denotes identified
T2276 505-509 IN denotes that
T2277 510-515 NN denotes NF-κB
T2278 516-526 NN denotes activation
T2279 527-529 VB denotes is
T2280 530-539 JJ denotes important
T2281 540-542 IN denotes in
T2282 543-556 JJ denotes M-CSF-induced
T2283 557-565 NN denotes monocyte
T2284 566-574 NN denotes survival
T2285 575-576 -LRB- denotes [
T2286 576-577 CD denotes 7
T2287 577-578 -RRB- denotes ]
T2288 580-582 IN denotes In
T2289 583-591 NN denotes addition
T2290 592-594 TO denotes to
T2291 595-598 PRP-DOLLAR- denotes its
T2292 599-603 NN denotes role
T2293 604-606 IN denotes in
T2294 607-618 JJ denotes mononuclear
T2295 619-628 NN denotes phagocyte
T2296 629-637 NN denotes survival
T2297 637-638 -COMMA- denotes ,
T2298 639-642 DT denotes the
T2299 643-656 NN denotes transcription
T2300 657-663 NN denotes factor
T2301 664-669 NN denotes NF-κB
T2302 670-679 VB denotes regulates
T2303 680-688 JJ denotes numerous
T2304 689-694 NN denotes genes
T2305 695-699 WDT denotes that
T2306 700-704 VB denotes play
T2307 705-714 JJ denotes important
T2308 715-720 NN denotes roles
T2309 721-723 IN denotes in
T2310 724-732 JJ denotes cellular
T2311 733-742 NN denotes signaling
T2312 742-743 -COMMA- denotes ,
T2313 744-750 NN denotes stress
T2314 751-759 NN denotes response
T2315 759-760 -COMMA- denotes ,
T2316 761-765 NN denotes cell
T2317 766-772 NN denotes growth
T2318 772-773 -COMMA- denotes ,
T2319 774-782 NN denotes survival
T2320 782-783 -COMMA- denotes ,
T2321 784-799 NN denotes differentiation
T2322 800-803 CC denotes and
T2323 804-816 NN denotes inflammation
T2324 817-818 -LRB- denotes [
T2325 818-819 CD denotes 8
T2326 819-820 -RRB- denotes ]
T2327 822-827 EX denotes There
T2328 828-831 VB denotes are
T2329 832-836 CD denotes five
T2330 837-844 NN denotes members
T2331 845-847 IN denotes in
T2332 848-851 DT denotes the
T2333 852-857 NN denotes NF-κB
T2334 858-864 NN denotes family
T2335 864-865 -COLON- denotes :
T2336 866-874 NN denotes RelA/p65
T2337 874-875 -COMMA- denotes ,
T2338 876-879 NN denotes p50
T2339 879-880 -COMMA- denotes ,
T2340 881-884 NN denotes p52
T2341 884-885 -COMMA- denotes ,
T2342 886-891 NN denotes c-Rel
T2343 892-895 CC denotes and
T2344 896-900 NN denotes RelB
T2345 902-905 DT denotes The
T2346 906-910 RB denotes most
T2347 911-917 JJ denotes common
T2348 918-928 VB denotes activating
T2349 929-936 NN denotes complex
T2350 937-939 VB denotes is
T2351 940-943 DT denotes the
T2352 944-951 NN denotes p50/p65
T2353 952-963 NN denotes heterodimer
T2354 963-964 -COMMA- denotes ,
T2355 965-971 VB denotes driven
T2356 972-974 IN denotes by
T2357 975-978 DT denotes the
T2358 979-989 NN denotes activation
T2359 990-996 NN denotes domain
T2360 997-999 IN denotes in
T2361 1000-1003 DT denotes the
T2362 1004-1009 NN denotes NF-κB
T2363 1010-1013 NN denotes p65
T2364 1014-1021 NN denotes subunit
T2365 1023-1028 NN denotes NF-κB
T2366 1029-1032 NN denotes p65
T2367 1033-1042 VB denotes regulates
T2368 1043-1052 JJ denotes important
T2369 1053-1066 JJ denotes developmental
T2370 1067-1076 NN denotes processes
T2371 1077-1078 -LRB- denotes [
T2372 1078-1079 CD denotes 9
T2373 1079-1080 -RRB- denotes ]
T2374 1080-1081 -COMMA- denotes ,
T2375 1082-1083 -LRB- denotes [
T2376 1083-1085 CD denotes 10
T2377 1085-1086 -RRB- denotes ]
T2378 1088-1092 NN denotes Mice
T2379 1093-1100 VB denotes lacking
T2380 1101-1106 NN denotes NF-κB
T2381 1107-1110 NN denotes p65
T2382 1111-1114 NN denotes die
T2383 1115-1117 IN denotes in
T2384 1118-1123 NN denotes utero
T2385 1124-1127 CC denotes and
T2386 1128-1132 VB denotes have
T2387 1133-1142 JJ denotes extensive
T2388 1143-1148 NN denotes liver
T2389 1149-1155 NN denotes damage
T2390 1156-1159 IN denotes via
T2391 1160-1168 VB denotes enhanced
T2392 1169-1178 NN denotes apoptosis
T2393 1179-1180 -LRB- denotes [
T2394 1180-1181 CD denotes 9
T2395 1181-1182 -RRB- denotes ]
T2396 1184-1193 JJ denotes Embryonic
T2397 1194-1205 NN denotes macrophages
T2398 1206-1210 IN denotes from
T2399 1211-1216 NN denotes NF-κB
T2400 1217-1220 NN denotes p65
T2401 1221-1225 JJ denotes null
T2402 1226-1230 NN denotes mice
T2403 1231-1234 VB denotes are
T2404 1235-1246 JJ denotes susceptible
T2405 1247-1249 TO denotes to
T2406 1250-1262 JJ denotes TNFα-induced
T2407 1263-1272 NN denotes apoptosis
T2408 1273-1278 WDT denotes which
T2409 1279-1281 VB denotes is
T2410 1282-1289 VB denotes rescued
T2411 1290-1292 IN denotes by
T2412 1293-1307 VB denotes overexpressing
T2413 1308-1311 DT denotes the
T2414 1312-1317 NN denotes NF-κB
T2415 1318-1321 NN denotes p65
T2416 1322-1329 NN denotes subunit
T2417 1330-1331 -LRB- denotes [
T2418 1331-1333 CD denotes 10
T2419 1333-1334 -RRB- denotes ]
T2420 1336-1344 RB denotes Moreover
T2421 1344-1345 -COMMA- denotes ,
T2422 1346-1356 VB denotes inhibiting
T2423 1357-1362 NN denotes NF-κB
T2424 1363-1370 VB denotes induces
T2425 1371-1375 NN denotes cell
T2426 1376-1381 NN denotes death
T2427 1382-1384 IN denotes in
T2428 1385-1389 JJ denotes many
T2429 1390-1394 NN denotes cell
T2430 1395-1400 NN denotes types
T2431 1401-1404 CC denotes and
T2432 1405-1425 JJ denotes cytokine-independent
T2433 1426-1434 NN denotes survival
T2434 1435-1437 VB denotes is
T2435 1438-1446 VB denotes mediated
T2436 1447-1449 IN denotes by
T2437 1450-1464 RB denotes constitutively
T2438 1465-1471 JJ denotes active
T2439 1472-1477 NN denotes NF-κB
T2440 1478-1480 IN denotes in
T2441 1481-1487 JJ denotes murine
T2442 1488-1499 NN denotes macrophages
T2443 1500-1501 -LRB- denotes [
T2444 1501-1503 CD denotes 11
T2445 1503-1504 -RRB- denotes ]
T2446 1506-1508 IN denotes In
T2447 1509-1518 NN denotes monocytes
T2448 1519-1522 CC denotes and
T2449 1523-1534 NN denotes macrophages
T2450 1534-1535 -COMMA- denotes ,
T2451 1536-1541 NN denotes NF-κB
T2452 1542-1544 VB denotes is
T2453 1545-1547 DT denotes an
T2454 1548-1557 JJ denotes important
T2455 1558-1573 JJ denotes transcriptional
T2456 1574-1580 NN denotes factor
T2457 1581-1584 IN denotes for
T2458 1585-1595 NN denotes expression
T2459 1596-1598 IN denotes of
T2460 1599-1608 NN denotes cytokines
T2461 1609-1612 CC denotes and
T2462 1613-1617 NN denotes cell
T2463 1618-1625 NN denotes surface
T2464 1626-1635 NN denotes receptors
T2465 1636-1637 -LRB- denotes [
T2466 1637-1639 CD denotes 12
T2467 1639-1640 -RRB- denotes ]
T2468 1642-1649 RB denotes However
T2469 1649-1650 -COMMA- denotes ,
T2470 1651-1657 IN denotes unlike
T2471 1658-1665 VB denotes resting
T2472 1666-1673 NN denotes T-cells
T2473 1673-1674 -COMMA- denotes ,
T2474 1675-1680 NN denotes NF-κB
T2475 1681-1683 VB denotes is
T2476 1684-1698 RB denotes constitutively
T2477 1699-1706 JJ denotes present
T2478 1707-1709 IN denotes in
T2479 1710-1713 DT denotes the
T2480 1714-1720 NN denotes nuclei
T2481 1721-1723 IN denotes of
T2482 1724-1731 JJ denotes primary
T2483 1732-1741 NN denotes monocytes
T2484 1742-1745 CC denotes and
T2485 1746-1755 JJ denotes monocytic
T2486 1756-1760 NN denotes cell
T2487 1761-1766 NN denotes lines
T2488 1767-1769 IN denotes in
T2489 1770-1773 DT denotes the
T2490 1774-1781 NN denotes absence
T2491 1782-1784 IN denotes of
T2492 1785-1794 JJ denotes exogenous
T2493 1795-1802 NN denotes stimuli
T2494 1803-1805 IN denotes as
T2495 1806-1818 VB denotes demonstrated
T2496 1819-1821 IN denotes by
T2497 1822-1830 NN denotes mobility
T2498 1831-1836 NN denotes shift
T2499 1837-1845 NN denotes analysis
T2500 1846-1847 -LRB- denotes [
T2501 1847-1849 CD denotes 13
T2502 1849-1850 -RRB- denotes ]
T2503 1852-1861 RB denotes Similarly
T2504 1861-1862 -COMMA- denotes ,
T2505 1863-1877 RB denotes constitutively
T2506 1878-1884 JJ denotes active
T2507 1885-1890 NN denotes NF-κB
T2508 1891-1894 VB denotes was
T2509 1895-1903 VB denotes observed
T2510 1904-1906 IN denotes in
T2511 1907-1912 JJ denotes human
T2512 1913-1921 JJ denotes alveolar
T2513 1922-1933 NN denotes macrophages
T2514 1934-1935 -LRB- denotes [
T2515 1935-1937 CD denotes 14
T2516 1937-1938 -RRB- denotes ]
T2517 1940-1942 IN denotes In
T2518 1943-1946 DT denotes the
T2519 1947-1964 JJ denotes classic/canonical
T2520 1965-1972 NN denotes pathway
T2521 1972-1973 -COMMA- denotes ,
T2522 1974-1977 DT denotes the
T2523 1978-1983 NN denotes NF-κB
T2524 1984-1991 NN denotes p50/p65
T2525 1992-1999 NN denotes complex
T2526 2000-2002 VB denotes is
T2527 2003-2014 VB denotes sequestered
T2528 2015-2017 IN denotes in
T2529 2018-2021 DT denotes the
T2530 2022-2029 NN denotes cytosol
T2531 2030-2032 IN denotes by
T2532 2033-2037 NNP denotes IκBα
T2533 2038-2039 -LRB- denotes [
T2534 2039-2041 CD denotes 15
T2535 2041-2042 -RRB- denotes ]
T2536 2044-2048 IN denotes Upon
T2537 2049-2060 NN denotes stimulation
T2538 2061-2063 IN denotes by
T2539 2064-2073 NN denotes cytokines
T2540 2074-2076 CC denotes or
T2541 2077-2079 NN denotes UV
T2542 2080-2089 NN denotes radiation
T2543 2089-2090 -COMMA- denotes ,
T2544 2091-2095 NNP denotes IκBα
T2545 2096-2098 VB denotes is
T2546 2099-2113 VB denotes phosphorylated
T2547 2113-2114 -COMMA- denotes ,
T2548 2115-2128 VB denotes ubiquitinated
T2549 2128-2129 -COMMA- denotes ,
T2550 2130-2133 CC denotes and
T2551 2134-2142 VB denotes degraded
T2552 2142-2143 -COMMA- denotes ,
T2553 2144-2153 VB denotes releasing
T2554 2154-2159 NN denotes NF-κB
T2555 2160-2167 NN denotes p50/p65
T2556 2168-2170 TO denotes to
T2557 2171-2182 VB denotes translocate
T2558 2183-2185 TO denotes to
T2559 2186-2189 DT denotes the
T2560 2190-2197 NN denotes nucleus
T2561 2198-2201 CC denotes and
T2562 2202-2215 VB denotes transactivate
T2563 2216-2222 NN denotes target
T2564 2223-2228 NN denotes genes
T2565 2230-2235 IN denotes After
T2566 2236-2239 PRP-DOLLAR- denotes its
T2567 2240-2247 NN denotes release
T2568 2248-2252 IN denotes from
T2569 2253-2257 NN denotes IκBα
T2570 2257-2258 -COMMA- denotes ,
T2571 2259-2264 NN denotes NF-κB
T2572 2265-2268 NN denotes p65
T2573 2269-2272 MD denotes can
T2574 2273-2280 VB denotes undergo
T2575 2281-2299 JJ denotes post-translational
T2576 2300-2312 NN denotes modification
T2577 2313-2315 TO denotes to
T2578 2316-2324 VB denotes activate
T2579 2325-2329 NN denotes gene
T2580 2330-2343 NN denotes transcription
T2581 2345-2348 DT denotes The
T2582 2349-2353 NN denotes role
T2583 2354-2356 IN denotes of
T2584 2357-2362 NN denotes NF-κB
T2585 2363-2366 NN denotes p65
T2586 2367-2382 NN denotes phosphorylation
T2587 2383-2385 IN denotes on
T2588 2386-2391 NN denotes NF-κB
T2589 2392-2407 JJ denotes transcriptional
T2590 2408-2416 NN denotes activity
T2591 2417-2423 VB denotes varies
T2592 2424-2426 IN denotes by
T2593 2427-2435 NN denotes stimulus
T2594 2435-2436 -COMMA- denotes ,
T2595 2437-2441 NN denotes time
T2596 2442-2444 IN denotes of
T2597 2445-2456 NN denotes stimulation
T2598 2457-2460 CC denotes and
T2599 2461-2465 NN denotes cell
T2600 2466-2470 NN denotes type
T2601 2471-2472 -LRB- denotes [
T2602 2472-2474 CD denotes 16
T2603 2474-2475 -RRB- denotes ]
T2604 2477-2485 JJ denotes Previous
T2605 2486-2494 NN denotes research
T2606 2495-2500 VB denotes shows
T2607 2501-2505 IN denotes that
T2608 2506-2521 NN denotes phosphorylation
T2609 2522-2524 IN denotes of
T2610 2525-2530 NN denotes NF-κB
T2611 2531-2534 NN denotes p65
T2612 2535-2537 IN denotes at
T2613 2538-2544 NN denotes Ser276
T2614 2544-2545 -COMMA- denotes ,
T2615 2546-2552 NN denotes Ser529
T2616 2553-2555 CC denotes or
T2617 2556-2562 NN denotes Ser536
T2618 2563-2568 VB denotes plays
T2619 2569-2571 DT denotes an
T2620 2572-2581 JJ denotes important
T2621 2582-2586 NN denotes role
T2622 2587-2589 IN denotes in
T2623 2590-2600 VB denotes regulating
T2624 2601-2616 JJ denotes transcriptional
T2625 2617-2625 NN denotes activity
T2626 2626-2628 IN denotes of
T2627 2629-2634 NN denotes NF-κB
T2628 2635-2636 -LRB- denotes [
T2629 2636-2638 CD denotes 17
T2630 2638-2639 -RRB- denotes ]
T2631 2641-2643 IN denotes In
T2632 2644-2656 JJ denotes TNFα-treated
T2633 2657-2663 JJ denotes murine
T2634 2664-2675 NN denotes fibroblasts
T2635 2675-2676 -COMMA- denotes ,
T2636 2677-2683 NN denotes Ser276
T2637 2684-2686 IN denotes of
T2638 2687-2692 NN denotes NF-κB
T2639 2693-2696 NN denotes p65
T2640 2697-2699 VB denotes is
T2641 2700-2714 VB denotes phosphorylated
T2642 2715-2717 IN denotes by
T2643 2718-2722 NN denotes MSK1
T2644 2723-2725 TO denotes to
T2645 2726-2733 VB denotes enhance
T2646 2734-2739 NN denotes NF-κB
T2647 2740-2755 JJ denotes transcriptional
T2648 2756-2764 NN denotes activity
T2649 2765-2766 -LRB- denotes [
T2650 2766-2768 CD denotes 18
T2651 2768-2769 -RRB- denotes ]
T2652 2771-2773 IN denotes In
T2653 2774-2785 NN denotes macrophages
T2654 2786-2793 VB denotes treated
T2655 2794-2798 IN denotes with
T2656 2799-2808 NN denotes endotoxin
T2657 2808-2809 -COMMA- denotes ,
T2658 2810-2815 NN denotes NF-κB
T2659 2816-2829 NN denotes transcription
T2660 2830-2838 NN denotes activity
T2661 2839-2841 VB denotes is
T2662 2842-2852 VB denotes associated
T2663 2853-2857 IN denotes with
T2664 2858-2873 NN denotes phosphorylation
T2665 2874-2876 IN denotes on
T2666 2877-2883 NN denotes Ser276
T2667 2884-2887 CC denotes and
T2668 2888-2894 NN denotes Ser536
T2669 2895-2899 WDT denotes that
T2670 2900-2902 VB denotes is
T2671 2903-2912 VB denotes regulated
T2672 2913-2920 IN denotes through
T2673 2921-2928 NN denotes protein
T2674 2929-2935 NN denotes kinase
T2675 2936-2937 NN denotes A
T2676 2938-2939 -LRB- denotes (
T2677 2939-2942 NN denotes PKA
T2678 2942-2943 -RRB- denotes )
T2679 2944-2947 CC denotes and
T2680 2948-2952 NN denotes IKKβ
T2681 2953-2965 RB denotes respectively
T2682 2965-2966 -LRB- denotes [
T2683 2966-2968 CD denotes 16
T2684 2968-2969 -RRB- denotes ]
T2685 2969-2970 -COMMA- denotes ,
T2686 2971-2972 -LRB- denotes [
T2687 2972-2974 CD denotes 19
T2688 2974-2975 -RRB- denotes ]
T2689 2977-2979 IN denotes In
T2690 2980-2985 JJ denotes human
T2691 2986-2987 NN denotes T
T2692 2988-2993 NN denotes cells
T2693 2993-2994 -COMMA- denotes ,
T2694 2995-3000 NN denotes NF-κB
T2695 3001-3004 NN denotes p65
T2696 3005-3007 VB denotes is
T2697 3008-3022 RB denotes constitutively
T2698 3023-3037 VB denotes phosphorylated
T2699 3038-3040 IN denotes on
T2700 3041-3047 NN denotes Ser536
T2701 3048-3050 TO denotes to
T2702 3051-3061 VB denotes facilitate
T2703 3062-3067 NN denotes NF-κB
T2704 3068-3071 NN denotes p65
T2705 3072-3079 JJ denotes nuclear
T2706 3080-3093 NN denotes translocation
T2707 3094-3103 VB denotes following
T2708 3104-3112 JJ denotes cellular
T2709 3113-3124 NN denotes stimulation
T2710 3125-3126 -LRB- denotes [
T2711 3126-3128 CD denotes 20
T2712 3128-3129 -RRB- denotes ]
T2713 3131-3143 VB denotes Accumulating
T2714 3144-3152 NN denotes evidence
T2715 3153-3160 VB denotes reveals
T2716 3161-3165 IN denotes that
T2717 3166-3171 NN denotes NF-κB
T2718 3172-3175 NN denotes p65
T2719 3176-3191 NN denotes phosphorylation
T2720 3192-3194 IN denotes at
T2721 3195-3201 NN denotes Ser276
T2722 3202-3204 VB denotes is
T2723 3205-3212 JJ denotes crucial
T2724 3213-3216 IN denotes for
T2725 3217-3220 PRP-DOLLAR- denotes its
T2726 3221-3236 JJ denotes transcriptional
T2727 3237-3245 NN denotes activity
T2728 3247-3251 IN denotes Upon
T2729 3252-3259 JJ denotes nuclear
T2730 3260-3273 NN denotes translocation
T2731 3273-3274 -COMMA- denotes ,
T2732 3275-3290 NN denotes phosphorylation
T2733 3291-3293 IN denotes of
T2734 3294-3300 NN denotes Ser276
T2735 3301-3303 IN denotes on
T2736 3304-3309 NN denotes NF-κB
T2737 3310-3313 NN denotes p65
T2738 3314-3316 IN denotes by
T2739 3317-3320 NN denotes PKA
T2740 3321-3329 VB denotes recruits
T2741 3330-3333 DT denotes the
T2742 3334-3347 NN denotes transcription
T2743 3348-3360 NN denotes co-activator
T2744 3360-3361 -COMMA- denotes ,
T2745 3362-3366 NN denotes p300
T2746 3367-3369 TO denotes to
T2747 3370-3380 VB denotes potentiate
T2748 3381-3396 JJ denotes NF-κB-regulated
T2749 3397-3401 NN denotes gene
T2750 3402-3415 NN denotes transcription
T2751 3416-3417 -LRB- denotes [
T2752 3417-3419 CD denotes 21
T2753 3419-3420 -RRB- denotes ]
T2754 3422-3429 RB denotes However
T2755 3429-3430 -COMMA- denotes ,
T2756 3431-3436 JJ denotes other
T2757 3437-3444 NN denotes studies
T2758 3445-3449 VB denotes show
T2759 3450-3454 IN denotes that
T2760 3455-3458 NN denotes PKA
T2761 3459-3467 VB denotes inhibits
T2762 3468-3483 JJ denotes NF-κB-regulated
T2763 3484-3488 NN denotes gene
T2764 3489-3499 NN denotes expression
T2765 3500-3502 IN denotes by
T2766 3503-3514 VB denotes stabilizing
T2767 3515-3519 NNP denotes IκBα
T2768 3520-3521 -LRB- denotes [
T2769 3521-3523 CD denotes 22
T2770 3523-3524 -RRB- denotes ]
T2771 3524-3525 -COMMA- denotes ,
T2772 3526-3527 -LRB- denotes [
T2773 3527-3529 CD denotes 23
T2774 3529-3530 -RRB- denotes ]
T2775 3532-3545 RB denotes Interestingly
T2776 3545-3546 -COMMA- denotes ,
T2777 3547-3550 DT denotes the
T2778 3551-3567 NN denotes serine/threonine
T2779 3568-3574 NN denotes kinase
T2780 3575-3580 NN denotes Pim-1
T2781 3581-3589 RB denotes directly
T2782 3590-3604 VB denotes phosphorylates
T2783 3605-3610 NN denotes NF-κB
T2784 3611-3614 NN denotes p65
T2785 3615-3617 IN denotes at
T2786 3618-3624 NN denotes Ser276
T2787 3625-3627 IN denotes by
T2788 3628-3639 VB denotes stabilizing
T2789 3640-3642 TO denotes to
T2790 3643-3650 VB denotes prevent
T2791 3651-3671 JJ denotes ubiquitin-proteasome
T2792 3672-3683 NN denotes degradation
T2793 3684-3685 -LRB- denotes [
T2794 3685-3687 CD denotes 24
T2795 3687-3688 -RRB- denotes ]
T2796 3690-3697 JJ denotes Several
T2797 3698-3703 JJ denotes other
T2798 3704-3719 NN denotes phosphorylation
T2799 3720-3725 NN denotes sites
T2800 3726-3729 VB denotes are
T2801 3730-3734 RB denotes also
T2802 3735-3744 VB denotes described
T2803 3745-3747 TO denotes to
T2804 3748-3755 VB denotes enhance
T2805 3756-3761 NN denotes NF-κB
T2806 3762-3766 NN denotes gene
T2807 3767-3782 NN denotes transactivation
T2808 3783-3784 -LRB- denotes [
T2809 3784-3786 CD denotes 25
T2810 3786-3787 -RRB- denotes ]
T2811 3789-3793 RB denotes Here
T2812 3793-3794 -COMMA- denotes ,
T2813 3795-3797 PRP denotes we
T2814 3798-3809 VB denotes investigate
T2815 3810-3813 DT denotes the
T2816 3814-3818 NN denotes role
T2817 3819-3821 IN denotes of
T2818 3822-3829 NN denotes protein
T2819 3830-3836 NN denotes kinase
T2820 3837-3838 NN denotes C
T2821 3839-3840 -LRB- denotes (
T2822 3840-3843 NN denotes PKC
T2823 3843-3844 -RRB- denotes )
T2824 3845-3847 IN denotes in
T2825 3848-3864 JJ denotes M-CSF-stimulated
T2826 3865-3870 NN denotes NF-κB
T2827 3871-3881 NN denotes activation
T2828 3883-3886 NN denotes PKC
T2829 3887-3895 NN denotes proteins
T2830 3896-3899 VB denotes are
T2831 3900-3915 JJ denotes multifunctional
T2832 3916-3923 NN denotes kinases
T2833 3924-3928 WDT denotes that
T2834 3929-3935 VB denotes differ
T2835 3936-3938 IN denotes in
T2836 3939-3948 NN denotes structure
T2837 3948-3949 -COMMA- denotes ,
T2838 3950-3958 NN denotes function
T2839 3959-3962 CC denotes and
T2840 3963-3972 NN denotes co-factor
T2841 3973-3984 NN denotes requirement
T2842 3985-3986 -LRB- denotes [
T2843 3986-3988 CD denotes 26
T2844 3988-3989 -RRB- denotes ]
T2845 3991-3995 NN denotes PKCs
T2846 3996-3999 VB denotes are
T2847 4000-4008 VB denotes involved
T2848 4009-4011 IN denotes in
T2849 4012-4019 JJ denotes diverse
T2850 4020-4024 NN denotes cell
T2851 4025-4034 NN denotes responses
T2852 4034-4035 -COMMA- denotes ,
T2853 4036-4045 VB denotes including
T2854 4046-4050 NN denotes cell
T2855 4051-4057 NN denotes growth
T2856 4057-4058 -COMMA- denotes ,
T2857 4059-4067 NN denotes survival
T2858 4067-4068 -COMMA- denotes ,
T2859 4069-4084 NN denotes differentiation
T2860 4085-4088 CC denotes and
T2861 4089-4100 NN denotes development
T2862 4101-4102 -LRB- denotes [
T2863 4102-4104 CD denotes 27
T2864 4104-4105 -RRB- denotes ]
T2865 4107-4110 DT denotes The
T2866 4111-4113 CD denotes 12
T2867 4114-4121 RB denotes closely
T2868 4122-4129 JJ denotes related
T2869 4130-4137 NN denotes enzymes
T2870 4138-4140 IN denotes of
T2871 4141-4144 DT denotes the
T2872 4145-4148 NN denotes PKC
T2873 4149-4155 NN denotes family
T2874 4156-4159 VB denotes are
T2875 4160-4167 VB denotes divided
T2876 4168-4172 IN denotes into
T2877 4173-4178 CD denotes three
T2878 4179-4186 NN denotes classes
T2879 4186-4187 -COLON- denotes :
T2880 4188-4200 JJ denotes conventional
T2881 4201-4202 -LRB- denotes (
T2882 4202-4207 NN denotes cPKCs
T2883 4207-4208 -COLON- denotes :
T2884 4209-4210 LS denotes α
T2885 4211-4213 NNP denotes βI
T2886 4214-4217 NNP denotes βII
T2887 4218-4221 CC denotes and
T2888 4222-4223 VB denotes γ
T2889 4224-4231 VB denotes require
T2890 4232-4236 NN denotes Ca2+
T2891 4237-4240 CC denotes and
T2892 4241-4255 NN denotes diacylglycerol
T2893 4256-4257 -LRB- denotes (
T2894 4257-4260 NN denotes DAG
T2895 4260-4261 -RRB- denotes )
T2896 4261-4262 -COLON- denotes ;
T2897 4263-4268 JJ denotes novel
T2898 4269-4270 -LRB- denotes (
T2899 4270-4275 NN denotes nPKCs
T2900 4275-4276 -COLON- denotes :
T2901 4277-4278 LS denotes δ
T2902 4278-4279 -COMMA- denotes ,
T2903 4280-4281 UH denotes ε
T2904 4281-4282 -COMMA- denotes ,
T2905 4283-4284 UH denotes η
T2906 4284-4285 -COMMA- denotes ,
T2907 4286-4287 NN denotes θ
T2908 4288-4291 CC denotes and
T2909 4292-4293 LS denotes μ
T2910 4293-4294 -RRB- denotes )
T2911 4295-4302 VB denotes require
T2912 4303-4306 NN denotes DAG
T2913 4306-4307 -COLON- denotes ;
T2914 4308-4311 CC denotes and
T2915 4312-4320 JJ denotes atypical
T2916 4321-4322 -LRB- denotes (
T2917 4322-4327 NN denotes aPKCs
T2918 4327-4328 -COLON- denotes :
T2919 4329-4330 LS denotes ξ
T2920 4330-4331 -COMMA- denotes ,
T2921 4332-4333 VB denotes ι
T2922 4334-4337 CC denotes and
T2923 4338-4339 LS denotes λ
T2924 4339-4340 -RRB- denotes )
T2925 4341-4348 VB denotes require
T2926 4349-4356 CC denotes neither
T2927 4357-4361 NN denotes Ca2+
T2928 4362-4365 CC denotes nor
T2929 4366-4369 NN denotes DAG
T2930 4371-4380 NN denotes Monocytes
T2931 4381-4384 CC denotes and
T2932 4385-4396 NN denotes macrophages
T2933 4397-4410 RB denotes predominantly
T2934 4411-4418 VB denotes express
T2935 4419-4431 JJ denotes conventional
T2936 4432-4435 NN denotes PKC
T2937 4436-4444 NN denotes isoforms
T2938 4445-4446 -LRB- denotes (
T2939 4446-4450 NN denotes PKCα
T2940 4451-4456 NN denotes PKCβI
T2941 4457-4460 CC denotes and
T2942 4461-4467 NN denotes PKCβII
T2943 4467-4468 -RRB- denotes )
T2944 4469-4472 CC denotes and
T2945 4473-4478 JJ denotes novel
T2946 4479-4483 NN denotes PKCs
T2947 4484-4485 -LRB- denotes (
T2948 4485-4489 NN denotes PKCδ
T2949 4490-4493 CC denotes and
T2950 4494-4498 NN denotes PKCε
T2951 4498-4499 -RRB- denotes )
T2952 4501-4513 JJ denotes Conventional
T2953 4514-4518 NN denotes PKCs
T2954 4519-4527 VB denotes regulate
T2955 4528-4543 NN denotes differentiation
T2956 4544-4546 IN denotes of
T2957 4547-4550 DT denotes the
T2958 4551-4556 JJ denotes human
T2959 4557-4570 JJ denotes promyelocytic
T2960 4571-4579 NN denotes leukemia
T2961 4580-4584 NN denotes cell
T2962 4585-4589 NN denotes line
T2963 4590-4594 NN denotes HL60
T2964 4595-4597 TO denotes to
T2965 4598-4609 NN denotes macrophages
T2966 4610-4611 -LRB- denotes [
T2967 4611-4613 CD denotes 28
T2968 4613-4614 -RRB- denotes ]
T2969 4616-4620 NN denotes PKCα
T2970 4621-4628 VB denotes induces
T2971 4629-4634 NN denotes IL-1α
T2972 4634-4635 -COMMA- denotes ,
T2973 4636-4640 NN denotes iNOS
T2974 4641-4644 CC denotes and
T2975 4645-4649 NN denotes TNFα
T2976 4650-4654 NN denotes mRNA
T2977 4655-4665 NN denotes production
T2978 4666-4671 IN denotes after
T2979 4672-4690 NN denotes lipopolysaccharide
T2980 4691-4692 -LRB- denotes (
T2981 4692-4695 NN denotes LPS
T2982 4695-4696 -RRB- denotes )
T2983 4697-4705 NN denotes exposure
T2984 4706-4707 -LRB- denotes [
T2985 4707-4709 CD denotes 29
T2986 4709-4710 -RRB- denotes ]
T2987 4712-4714 IN denotes In
T2988 4715-4723 NN denotes addition
T2989 4723-4724 -COMMA- denotes ,
T2990 4725-4737 VB denotes accumulating
T2991 4738-4746 NN denotes evidence
T2992 4747-4755 VB denotes suggests
T2993 4756-4760 IN denotes that
T2994 4761-4773 JJ denotes conventional
T2995 4774-4778 NN denotes PKCs
T2996 4779-4783 IN denotes like
T2997 4784-4788 NN denotes PKCα
T2998 4789-4793 VB denotes have
T2999 4794-4808 JJ denotes anti-apoptotic
T3000 4809-4818 NN denotes functions
T3001 4820-4823 IN denotes For
T3002 4824-4831 NN denotes example
T3003 4831-4832 -COMMA- denotes ,
T3004 4833-4837 NN denotes PKCα
T3005 4838-4840 VB denotes is
T3006 4841-4854 VB denotes overexpressed
T3007 4855-4857 IN denotes in
T3008 4858-4859 DT denotes a
T3009 4860-4867 NN denotes variety
T3010 4868-4870 IN denotes of
T3011 4871-4876 NN denotes tumor
T3012 4877-4882 NN denotes cells
T3013 4883-4892 VB denotes including
T3014 4893-4900 NN denotes gliomas
T3015 4900-4901 -COMMA- denotes ,
T3016 4902-4907 NN denotes liver
T3017 4907-4908 -COMMA- denotes ,
T3018 4909-4912 CC denotes and
T3019 4913-4917 NN denotes lung
T3020 4918-4919 -LRB- denotes [
T3021 4919-4921 CD denotes 30
T3022 4921-4922 -RRB- denotes ]
T3023 4922-4923 -COMMA- denotes ,
T3024 4924-4925 -LRB- denotes [
T3025 4925-4927 CD denotes 31
T3026 4927-4928 -RRB- denotes ]
T3027 4930-4932 IN denotes In
T3028 4933-4943 JJ denotes epithelial
T3029 4944-4949 NN denotes cells
T3030 4949-4950 -COMMA- denotes ,
T3031 4951-4961 NN denotes inhibition
T3032 4962-4964 IN denotes of
T3033 4965-4969 NN denotes PKCα
T3034 4970-4977 VB denotes induces
T3035 4978-4992 JJ denotes PKCδ-dependent
T3036 4993-5002 NN denotes apoptosis
T3037 5003-5004 -LRB- denotes [
T3038 5004-5006 CD denotes 31
T3039 5006-5007 -RRB- denotes ]
T3040 5009-5022 RB denotes Interestingly
T3041 5022-5023 -COMMA- denotes ,
T3042 5024-5026 IN denotes in
T3043 5027-5032 JJ denotes human
T3044 5033-5042 NN denotes monocytes
T3045 5043-5046 CC denotes and
T3046 5047-5059 JJ denotes premonocytic
T3047 5060-5065 NN denotes THP-1
T3048 5066-5074 NN denotes leukemia
T3049 5075-5080 NN denotes cells
T3050 5080-5081 -COMMA- denotes ,
T3051 5082-5087 JJ denotes novel
T3052 5088-5092 NN denotes PKCs
T3053 5093-5097 IN denotes like
T3054 5098-5102 NN denotes PKCδ
T3055 5103-5107 VB denotes have
T3056 5108-5111 DT denotes the
T3057 5112-5120 JJ denotes opposite
T3058 5121-5127 NN denotes effect
T3059 5128-5130 IN denotes on
T3060 5131-5135 NN denotes cell
T3061 5136-5144 NN denotes survival
T3062 5144-5145 -COMMA- denotes ,
T3063 5146-5150 NNP denotes Voss
T3064 5151-5153 FW denotes et
T3065 5154-5156 FW denotes al
T3066 5157-5163 VB denotes showed
T3067 5164-5168 IN denotes that
T3068 5169-5173 NN denotes PKCδ
T3069 5174-5182 RB denotes directly
T3070 5183-5197 VB denotes phosphorylates
T3071 5198-5207 NN denotes caspase-3
T3072 5208-5211 CC denotes and
T3073 5212-5220 VB denotes promotes
T3074 5221-5238 JJ denotes etoposide-induced
T3075 5239-5248 NN denotes apoptosis
T3076 5249-5250 -LRB- denotes [
T3077 5250-5252 CD denotes 32
T3078 5252-5253 -RRB- denotes ]
T3079 5255-5263 RB denotes Moreover
T3080 5263-5264 -COMMA- denotes ,
T3081 5265-5273 JJ denotes knockout
T3082 5274-5279 NN denotes mouse
T3083 5280-5287 NN denotes studies
T3084 5288-5295 VB denotes suggest
T3085 5296-5300 IN denotes that
T3086 5301-5308 DT denotes another
T3087 5309-5314 JJ denotes novel
T3088 5315-5318 NN denotes PKC
T3089 5318-5319 -COMMA- denotes ,
T3090 5320-5324 NN denotes PKCε
T3091 5325-5327 VB denotes is
T3092 5328-5338 RB denotes critically
T3093 5339-5347 VB denotes involved
T3094 5348-5350 IN denotes in
T3095 5351-5356 JJ denotes early
T3096 5357-5369 JJ denotes LPS-mediated
T3097 5370-5379 NN denotes signaling
T3098 5380-5382 IN denotes in
T3099 5383-5392 VB denotes activated
T3100 5393-5404 NN denotes macrophages
T3101 5405-5406 -LRB- denotes [
T3102 5406-5408 CD denotes 33
T3103 5408-5409 -RRB- denotes ]
T3104 5411-5421 RB denotes Previously
T3105 5421-5422 -COMMA- denotes ,
T3106 5423-5425 PRP denotes we
T3107 5426-5434 VB denotes reported
T3108 5435-5439 IN denotes that
T3109 5440-5445 NN denotes M-CSF
T3110 5446-5454 VB denotes promotes
T3111 5455-5463 NN denotes monocyte
T3112 5464-5472 NN denotes survival
T3113 5473-5480 IN denotes through
T3114 5481-5484 DT denotes the
T3115 5485-5495 NN denotes activation
T3116 5496-5498 IN denotes of
T3117 5499-5502 DT denotes the
T3118 5503-5512 NN denotes PI3-K/AKT
T3119 5513-5520 NN denotes pathway
T3120 5521-5522 -LRB- denotes [
T3121 5522-5523 CD denotes 3
T3122 5523-5524 -RRB- denotes ]
T3123 5526-5528 IN denotes In
T3124 5529-5537 NN denotes addition
T3125 5538-5540 TO denotes to
T3126 5541-5544 NN denotes AKT
T3127 5545-5555 NN denotes activation
T3128 5555-5556 -COMMA- denotes ,
T3129 5557-5562 NN denotes M-CSF
T3130 5563-5573 VB denotes stimulates
T3131 5574-5577 NN denotes PKC
T3132 5578-5580 IN denotes in
T3133 5581-5586 JJ denotes human
T3134 5587-5596 NN denotes monocytes
T3135 5597-5600 CC denotes and
T3136 5601-5610 VB denotes increases
T3137 5611-5616 NN denotes NF-κB
T3138 5617-5620 NN denotes DNA
T3139 5621-5628 NN denotes binding
T3140 5629-5630 -LRB- denotes [
T3141 5630-5632 CD denotes 34
T3142 5632-5633 -RRB- denotes ]
T3143 5635-5642 RB denotes However
T3144 5642-5643 -COMMA- denotes ,
T3145 5644-5651 IN denotes whether
T3146 5652-5655 NN denotes PKC
T3147 5656-5662 CC denotes and/or
T3148 5663-5668 NN denotes NF-κB
T3149 5669-5679 NN denotes activation
T3150 5680-5682 VB denotes is
T3151 5683-5691 JJ denotes critical
T3152 5692-5694 IN denotes in
T3153 5695-5711 JJ denotes M-CSF-stimulated
T3154 5712-5723 JJ denotes mononuclear
T3155 5724-5733 NN denotes phagocyte
T3156 5734-5742 NN denotes survival
T3157 5743-5749 CC denotes and/or
T3158 5750-5765 NN denotes differentiation
T3159 5766-5768 VB denotes is
T3160 5769-5776 JJ denotes unclear
T3161 5778-5780 IN denotes In
T3162 5781-5786 JJ denotes other
T3163 5787-5792 NN denotes cells
T3164 5792-5793 -COMMA- denotes ,
T3165 5794-5797 NN denotes PKC
T3166 5798-5803 VB denotes plays
T3167 5804-5806 DT denotes an
T3168 5807-5816 JJ denotes important
T3169 5817-5821 NN denotes role
T3170 5822-5824 IN denotes in
T3171 5825-5830 NN denotes NF-κB
T3172 5831-5841 NN denotes activation
T3173 5842-5845 CC denotes and
T3174 5846-5850 NN denotes cell
T3175 5851-5859 NN denotes survival
T3176 5860-5861 -LRB- denotes [
T3177 5861-5863 CD denotes 35
T3178 5863-5864 -RRB- denotes ]
T3179 5864-5865 -COMMA- denotes ,
T3180 5866-5873 RB denotes however
T3181 5874-5877 DT denotes the
T3182 5878-5886 JJ denotes specific
T3183 5887-5897 NN denotes mechanisms
T3184 5898-5900 IN denotes of
T3185 5901-5905 DT denotes this
T3186 5906-5916 NN denotes activation
T3187 5917-5920 CC denotes and
T3188 5921-5924 DT denotes the
T3189 5925-5935 JJ denotes biological
T3190 5936-5943 NN denotes effects
T3191 5944-5946 IN denotes on
T3192 5947-5955 JJ denotes cellular
T3193 5956-5965 NN denotes phenotype
T3194 5966-5969 VB denotes are
T3195 5970-5973 RB denotes not
T3196 5974-5979 VB denotes known
T3197 5981-5990 RB denotes Therefore
T3198 5990-5991 -COMMA- denotes ,
T3199 5992-5994 PRP denotes we
T3200 5995-6002 VB denotes focused
T3201 6003-6005 IN denotes at
T3202 6006-6019 VB denotes understanding
T3203 6020-6023 DT denotes the
T3204 6024-6028 NN denotes role
T3205 6029-6031 IN denotes of
T3206 6032-6035 NN denotes PKC
T3207 6036-6038 IN denotes in
T3208 6039-6042 DT denotes the
T3209 6043-6053 NN denotes regulation
T3210 6054-6056 IN denotes of
T3211 6057-6062 NN denotes NF-κB
T3212 6063-6073 NN denotes activation
T3213 6074-6077 CC denotes and
T3214 6078-6091 JJ denotes M-CSF-induced
T3215 6092-6100 NN denotes monocyte
T3216 6101-6109 NN denotes survival
T3217 6111-6115 RB denotes Here
T3218 6116-6118 PRP denotes we
T3219 6119-6131 VB denotes demonstrates
T3220 6132-6136 IN denotes that
T3221 6137-6142 NN denotes M-CSF
T3222 6143-6154 VB denotes upregulated
T3223 6155-6158 DT denotes the
T3224 6159-6164 NN denotes NF-κB
T3225 6165-6178 NN denotes transcription
T3226 6179-6182 CC denotes and
T3227 6183-6187 NN denotes cell
T3228 6188-6196 NN denotes survival
T3229 6197-6199 IN denotes in
T3230 6200-6205 JJ denotes human
T3231 6206-6209 CC denotes and
T3232 6210-6215 NN denotes mouse
T3233 6216-6227 NN denotes macrophages
T3234 6229-6233 DT denotes This
T3235 6234-6242 NN denotes activity
T3236 6243-6246 VB denotes was
T3237 6247-6254 VB denotes reduced
T3238 6255-6257 IN denotes by
T3239 6258-6261 DT denotes the
T3240 6262-6274 JJ denotes conventional
T3241 6274-6275 -COMMA- denotes ,
T3242 6276-6279 CC denotes but
T3243 6280-6283 RB denotes not
T3244 6284-6289 JJ denotes novel
T3245 6289-6290 -COMMA- denotes ,
T3246 6291-6294 NN denotes PKC
T3247 6295-6305 NN denotes inhibitors
T3248 6305-6306 -COMMA- denotes ,
T3249 6307-6315 JJ denotes dominant
T3250 6316-6324 JJ denotes negative
T3251 6325-6329 NN denotes PKCα
T3252 6330-6340 NN denotes constructs
T3253 6341-6343 CC denotes or
T3254 6344-6348 NN denotes PKCα
T3255 6349-6354 NN denotes siRNA
T3256 6356-6368 JJ denotes Conventional
T3257 6369-6372 NN denotes PKC
T3258 6373-6382 VB denotes regulated
T3259 6383-6398 JJ denotes NF-κB-regulated
T3260 6399-6403 NN denotes gene
T3261 6404-6414 NN denotes expression
T3262 6415-6418 CC denotes and
T3263 6419-6434 NN denotes phosphorylation
T3264 6435-6437 IN denotes of
T3265 6438-6444 NN denotes Ser276
T3266 6445-6447 IN denotes of
T3267 6448-6453 NN denotes NF-κB
T3268 6454-6457 NN denotes p65
T3269 6458-6466 VB denotes occurred
T3270 6467-6469 IN denotes in
T3271 6470-6472 DT denotes an
T3272 6473-6488 JJ denotes M-CSF-dependent
T3273 6489-6496 NN denotes fashion
T3274 6497-6508 VB denotes correlating
T3275 6509-6513 IN denotes with
T3276 6514-6517 PRP-DOLLAR- denotes its
T3277 6518-6525 JJ denotes maximal
T3278 6526-6541 JJ denotes transcriptional
T3279 6542-6550 NN denotes activity
T3280 6552-6563 RB denotes Furthermore
T3281 6563-6564 -COMMA- denotes ,
T3282 6565-6579 JJ denotes PKCα-regulated
T3283 6580-6595 NN denotes phosphorylation
T3284 6596-6598 IN denotes of
T3285 6599-6605 NN denotes Ser276
T3286 6606-6608 IN denotes of
T3287 6609-6614 NN denotes NF-κB
T3288 6615-6618 NN denotes p65
T3289 6619-6624 VB denotes plays
T3290 6625-6627 DT denotes an
T3291 6628-6637 JJ denotes important
T3292 6638-6642 NN denotes role
T3293 6643-6645 IN denotes in
T3294 6646-6656 VB denotes regulating
T3295 6657-6660 PRP-DOLLAR- denotes its
T3296 6661-6669 NN denotes activity
T3297 6670-6672 IN denotes in
T3298 6673-6684 JJ denotes mononuclear
T3299 6685-6695 NN denotes phagocytes
T3300 6696-6699 CC denotes and
T3301 6700-6706 JJ denotes murine
T3302 6707-6716 JJ denotes embryonic
T3303 6717-6728 NN denotes fibroblasts
T15744 530-539 JJ denotes important
T15745 540-542 IN denotes in
R1754 T2187 T2188 arg1Of Monocytes,are
R1755 T2187 T2189 arg2Of Monocytes,produced
R1756 T2187 T2195 arg1Of Monocytes,circulate
R1757 T2189 T2188 arg2Of produced,are
R1758 T2189 T2190 arg1Of produced,in
R1759 T2189 T2194 arg1Of produced,and
R1762 T2193 T2190 arg2Of marrow,in
R1763 T2193 T2191 arg1Of marrow,the
R1764 T2193 T2192 arg1Of marrow,bone
R1765 T2195 T2194 arg2Of circulate,and
R1766 T2195 T2196 arg1Of circulate,in
R1768 T2197 T2196 arg2Of blood,in
R1769 T2197 T2198 arg1Of blood,for
R1771 T2200 T2198 arg2Of hours,for
R1772 T2200 T2199 arg1Of hours,24–48
R1773 T2200 T2201 arg1Of hours,[
R1774 T2202 T2201 arg2Of 1,[
R1775 T2203 T2201 arg3Of ],[
R1777 T2206 T2204 arg2Of absence,In
R1778 T2206 T2205 arg1Of absence,the
R1779 T2206 T2207 arg1Of absence,of
R1781 T2208 T2207 arg2Of serum,of
R1783 T2210 T2211 arg1Of monocytes,die
R1784 T2211 T2204 arg1Of die,In
R1785 T2211 T2209 arg1Of die,","
R1786 T2211 T2212 arg1Of die,via
R1787 T2211 T2214 arg1Of die,[
R1788 T2211 T2217 arg1Of die,","
R1789 T2211 T2218 arg1Of die,[
R1790 T2213 T2212 arg2Of apoptosis,via
R1792 T2215 T2214 arg2Of 1,[
R1793 T2216 T2214 arg3Of ],[
R1796 T2219 T2218 arg2Of 2,[
R1797 T2220 T2218 arg3Of ],[
R1799 T2223 T2221 arg1Of factor,Macrophage
R1800 T2223 T2222 arg1Of factor,colony-stimulating
R1801 T2223 T2224 arg1Of factor,(
R1802 T2223 T2227 arg1Of factor,stimulates
R1803 T2225 T2224 arg2Of M-CSF,(
R1805 T2226 T2224 arg3Of ),(
R1807 T2230 T2228 arg1Of survival,mononuclear
R1808 T2230 T2229 arg1Of survival,phagocyte
R1809 T2230 T2231 arg1Of survival,and
R1811 T2231 T2227 arg2Of and,stimulates
R1812 T2232 T2231 arg2Of differentiation,and
R1813 T2232 T2233 arg1Of differentiation,[
R1814 T2234 T2233 arg2Of 3,[
R1816 T2235 T2233 arg3Of ],[
R1819 T2240 T2238 arg1Of survival,M-CSF-mediated
R1820 T2240 T2239 arg1Of survival,cell
R1821 T2240 T2241 arg1Of survival,and
R1822 T2241 T2243 arg1Of and,is
R1823 T2241 T2244 arg2Of and,associated
R1825 T2242 T2241 arg2Of activation,and
R1828 T2244 T2236 arg1Of associated,Importantly
R1829 T2244 T2237 arg1Of associated,","
R1830 T2244 T2243 arg2Of associated,is
R1831 T2244 T2245 arg1Of associated,with
R1832 T2244 T2265 arg1Of associated,","
R1833 T2244 T2266 arg1Of associated,[
R1834 T2244 T2269 arg1Of associated,","
R1835 T2244 T2270 arg1Of associated,[
R1837 T2247 T2245 arg2Of variety,with
R1838 T2247 T2246 arg1Of variety,a
R1839 T2247 T2248 arg1Of variety,of
R1841 T2250 T2248 arg2Of diseases,of
R1842 T2250 T2249 arg1Of diseases,human
R1843 T2250 T2251 arg1Of diseases,","
R1844 T2250 T2252 arg1Of diseases,including
R1846 T2253 T2254 arg1Of atherosclerosis,","
R1847 T2254 T2258 arg1Of ",",and
R1849 T2257 T2254 arg2Of sclerosis,","
R1850 T2257 T2255 arg1Of sclerosis,transplant
R1851 T2257 T2256 arg1Of sclerosis,vascular
R1852 T2258 T2252 arg2Of and,including
R1854 T2261 T2258 arg2Of metastasis,and
R1855 T2261 T2259 arg1Of metastasis,breast
R1856 T2261 T2260 arg1Of metastasis,cancer
R1857 T2261 T2262 arg1Of metastasis,[
R1858 T2263 T2262 arg2Of 4,[
R1860 T2264 T2262 arg3Of ],[
R1862 T2267 T2266 arg2Of 5,[
R1863 T2268 T2266 arg3Of ],[
R1866 T2271 T2270 arg2Of 6,[
R1867 T2272 T2270 arg3Of ],[
R1869 T2273 T2275 arg1Of We,identified
R1870 T2275 T2274 arg1Of identified,previously
R1872 T2278 T2277 arg1Of activation,NF-κB
R1873 T2278 T2279 arg1Of activation,is
R1874 T2278 T2280 arg1Of activation,important
R1875 T2279 T2275 arg2Of is,identified
R1876 T2279 T2276 arg1Of is,that
R1877 T2280 T2279 arg2Of important,is
R1878 T2280 T2281 arg1Of important,in
R1880 T2284 T2281 arg2Of survival,in
R1881 T2284 T2282 arg1Of survival,M-CSF-induced
R1882 T2284 T2283 arg1Of survival,monocyte
R1883 T2284 T2285 arg1Of survival,[
R1884 T2286 T2285 arg2Of 7,[
R1886 T2287 T2285 arg3Of ],[
R1887 T2289 T2288 arg2Of addition,In
R1888 T2289 T2290 arg1Of addition,to
R1890 T2292 T2290 arg2Of role,to
R1891 T2292 T2291 arg1Of role,its
R1892 T2292 T2293 arg1Of role,in
R1895 T2296 T2293 arg2Of survival,in
R1896 T2296 T2294 arg1Of survival,mononuclear
R1897 T2296 T2295 arg1Of survival,phagocyte
R1899 T2301 T2298 arg1Of NF-κB,the
R1900 T2301 T2299 arg1Of NF-κB,transcription
R1901 T2301 T2300 arg1Of NF-κB,factor
R1902 T2301 T2302 arg1Of NF-κB,regulates
R1903 T2302 T2288 arg1Of regulates,In
R1904 T2302 T2297 arg1Of regulates,","
R1906 T2304 T2302 arg2Of genes,regulates
R1907 T2304 T2303 arg1Of genes,numerous
R1908 T2304 T2305 arg1Of genes,that
R1909 T2304 T2306 arg1Of genes,play
R1910 T2306 T2309 arg1Of play,in
R1912 T2306 T2324 arg1Of play,[
R1914 T2308 T2306 arg2Of roles,play
R1915 T2308 T2307 arg1Of roles,important
R1917 T2311 T2310 arg1Of signaling,cellular
R1918 T2311 T2312 arg1Of signaling,","
R1920 T2312 T2315 arg1Of ",",","
R1921 T2314 T2312 arg2Of response,","
R1922 T2314 T2313 arg1Of response,stress
R1923 T2315 T2318 arg1Of ",",","
R1924 T2317 T2315 arg2Of growth,","
R1925 T2317 T2316 arg1Of growth,cell
R1927 T2318 T2320 arg1Of ",",","
R1928 T2319 T2318 arg2Of survival,","
R1929 T2320 T2322 arg1Of ",",and
R1931 T2321 T2320 arg2Of differentiation,","
R1932 T2322 T2309 arg2Of and,in
R1934 T2323 T2322 arg2Of inflammation,and
R1935 T2325 T2324 arg2Of 8,[
R1937 T2326 T2324 arg3Of ],[
R1938 T2327 T2328 arg1Of There,are
R1939 T2328 T2335 arg1Of are,:
R1941 T2330 T2328 arg2Of members,are
R1942 T2330 T2329 arg1Of members,five
R1943 T2330 T2331 arg1Of members,in
R1945 T2334 T2331 arg2Of family,in
R1946 T2334 T2332 arg1Of family,the
R1947 T2334 T2333 arg1Of family,NF-κB
R1949 T2336 T2337 arg1Of RelA/p65,","
R1950 T2337 T2339 arg1Of ",",","
R1952 T2338 T2337 arg2Of p50,","
R1953 T2339 T2341 arg1Of ",",","
R1958 T2340 T2339 arg2Of p52,","
R1959 T2341 T2343 arg1Of ",",and
R1961 T2342 T2341 arg2Of c-Rel,","
R1962 T2344 T2343 arg2Of RelB,and
R1965 T2347 T2346 arg1Of common,most
R1967 T2349 T2345 arg1Of complex,The
R1968 T2349 T2347 arg1Of complex,common
R1969 T2349 T2348 arg1Of complex,activating
R1970 T2349 T2350 arg1Of complex,is
R1971 T2349 T2355 arg2Of complex,driven
R1972 T2350 T2354 arg1Of is,","
R1973 T2350 T2355 modOf is,driven
R1974 T2353 T2350 arg2Of heterodimer,is
R1975 T2353 T2351 arg1Of heterodimer,the
R1976 T2353 T2352 arg1Of heterodimer,p50/p65
R1979 T2359 T2355 arg1Of domain,driven
R1980 T2359 T2356 arg2Of domain,by
R1981 T2359 T2357 arg1Of domain,the
R1982 T2359 T2358 arg1Of domain,activation
R1983 T2359 T2360 arg1Of domain,in
R1985 T2364 T2360 arg2Of subunit,in
R1986 T2364 T2361 arg1Of subunit,the
R1987 T2364 T2362 arg1Of subunit,NF-κB
R1988 T2364 T2363 arg1Of subunit,p65
R1989 T2438 T2437 arg1Of active,constitutively
R1990 T2366 T2365 arg1Of p65,NF-κB
R1991 T2366 T2367 arg1Of p65,regulates
R1992 T2367 T2371 arg1Of regulates,[
R1993 T2367 T2374 arg1Of regulates,","
R1994 T2367 T2375 arg1Of regulates,[
R1995 T2370 T2367 arg2Of processes,regulates
R1996 T2370 T2368 arg1Of processes,important
R1997 T2370 T2369 arg1Of processes,developmental
R1998 T2439 T2435 arg1Of NF-κB,mediated
R1999 T2372 T2371 arg2Of 9,[
R2000 T2373 T2371 arg3Of ],[
R2001 T2439 T2436 arg2Of NF-κB,by
R2002 T2439 T2438 arg1Of NF-κB,active
R2003 T2376 T2375 arg2Of 10,[
R2004 T2439 T2440 arg1Of NF-κB,in
R2005 T2377 T2375 arg3Of ],[
R2006 T2442 T2440 arg2Of macrophages,in
R2007 T2378 T2379 arg1Of Mice,lacking
R2008 T2378 T2386 arg1Of Mice,have
R2009 T2379 T2383 arg1Of lacking,in
R2010 T2382 T2379 arg2Of die,lacking
R2011 T2382 T2380 arg1Of die,NF-κB
R2012 T2382 T2381 arg1Of die,p65
R2013 T2442 T2441 arg1Of macrophages,murine
R2014 T2384 T2383 arg2Of utero,in
R2015 T2442 T2443 arg1Of macrophages,[
R2016 T2444 T2443 arg2Of 11,[
R2017 T2386 T2385 arg1Of have,and
R2018 T2389 T2386 arg2Of damage,have
R2019 T2445 T2443 arg3Of ],[
R2020 T2389 T2387 arg1Of damage,extensive
R2021 T2389 T2388 arg1Of damage,liver
R2022 T2389 T2390 arg1Of damage,via
R2023 T2392 T2390 arg2Of apoptosis,via
R2024 T2392 T2391 arg2Of apoptosis,enhanced
R2025 T2392 T2393 arg1Of apoptosis,[
R2026 T2394 T2393 arg2Of 9,[
R2027 T2395 T2393 arg3Of ],[
R2028 T2447 T2448 arg1Of monocytes,and
R2029 T2397 T2396 arg1Of macrophages,Embryonic
R2030 T2397 T2398 arg1Of macrophages,from
R2031 T2397 T2403 arg1Of macrophages,are
R2032 T2397 T2404 arg1Of macrophages,susceptible
R2033 T2448 T2446 arg2Of and,In
R2034 T2449 T2448 arg2Of macrophages,and
R2035 T2402 T2398 arg2Of mice,from
R2036 T2402 T2399 arg1Of mice,NF-κB
R2037 T2402 T2400 arg1Of mice,p65
R2038 T2402 T2401 arg1Of mice,null
R2039 T2404 T2403 arg2Of susceptible,are
R2040 T2404 T2405 arg1Of susceptible,to
R2041 T2451 T2452 arg1Of NF-κB,is
R2042 T2407 T2405 arg2Of apoptosis,to
R2043 T2407 T2406 arg1Of apoptosis,TNFα-induced
R2044 T2407 T2408 arg1Of apoptosis,which
R2045 T2407 T2409 arg1Of apoptosis,is
R2046 T2407 T2410 arg2Of apoptosis,rescued
R2047 T2452 T2446 arg1Of is,In
R2048 T2410 T2409 arg2Of rescued,is
R2049 T2410 T2411 arg1Of rescued,by
R2050 T2412 T2411 arg2Of overexpressing,by
R2051 T2412 T2417 arg1Of overexpressing,[
R2052 T2452 T2450 arg1Of is,","
R2053 T2456 T2452 arg2Of factor,is
R2054 T2416 T2412 arg2Of subunit,overexpressing
R2055 T2416 T2413 arg1Of subunit,the
R2056 T2416 T2414 arg1Of subunit,NF-κB
R2057 T2416 T2415 arg1Of subunit,p65
R2058 T2418 T2417 arg2Of 10,[
R2059 T2419 T2417 arg3Of ],[
R2060 T2422 T2424 arg1Of inhibiting,induces
R2061 T2456 T2453 arg1Of factor,an
R2062 T2423 T2422 arg2Of NF-κB,inhibiting
R2063 T2456 T2454 arg1Of factor,important
R2064 T2424 T2427 arg1Of induces,in
R2065 T2456 T2455 arg1Of factor,transcriptional
R2066 T2424 T2431 arg1Of induces,and
R2067 T2426 T2424 arg2Of death,induces
R2068 T2426 T2425 arg1Of death,cell
R2069 T2456 T2457 arg1Of factor,for
R2070 T2458 T2457 arg2Of expression,for
R2071 T2430 T2427 arg2Of types,in
R2072 T2430 T2428 arg1Of types,many
R2073 T2430 T2429 arg1Of types,cell
R2074 T2431 T2420 arg1Of and,Moreover
R2075 T2431 T2421 arg1Of and,","
R2076 T2433 T2432 arg1Of survival,cytokine-independent
R2077 T2433 T2434 arg1Of survival,is
R2078 T2433 T2435 arg2Of survival,mediated
R2079 T2435 T2431 arg2Of mediated,and
R2080 T2435 T2434 arg2Of mediated,is
R2081 T2458 T2459 arg1Of expression,of
R2082 T2460 T2461 arg1Of cytokines,and
R2083 T2461 T2459 arg2Of and,of
R2084 T2464 T2461 arg2Of receptors,and
R2085 T2534 T2533 arg2Of 15,[
R2086 T2464 T2462 arg1Of receptors,cell
R2087 T2535 T2533 arg3Of ],[
R2088 T2464 T2463 arg1Of receptors,surface
R2089 T2464 T2465 arg1Of receptors,[
R2090 T2537 T2536 arg2Of stimulation,Upon
R2091 T2537 T2538 arg1Of stimulation,by
R2092 T2466 T2465 arg2Of 12,[
R2093 T2539 T2540 arg1Of cytokines,or
R2094 T2540 T2538 arg2Of or,by
R2095 T2467 T2465 arg3Of ],[
R2096 T2542 T2540 arg2Of radiation,or
R2097 T2542 T2541 arg1Of radiation,UV
R2098 T2544 T2545 arg1Of IκBα,is
R2099 T2544 T2546 arg2Of IκBα,phosphorylated
R2100 T2472 T2470 arg2Of T-cells,unlike
R2101 T2544 T2548 arg2Of IκBα,ubiquitinated
R2102 T2544 T2551 arg2Of IκBα,degraded
R2103 T2544 T2553 arg1Of IκBα,releasing
R2104 T2546 T2547 arg1Of phosphorylated,","
R2105 T2547 T2550 arg1Of ",",and
R2106 T2548 T2547 arg2Of ubiquitinated,","
R2107 T2472 T2471 arg1Of T-cells,resting
R2108 T2474 T2475 arg1Of NF-κB,is
R2109 T2550 T2536 arg1Of and,Upon
R2110 T2550 T2543 arg1Of and,","
R2111 T2550 T2545 arg2Of and,is
R2112 T2550 T2549 arg1Of and,","
R2113 T2550 T2552 arg1Of and,","
R2114 T2550 T2553 modOf and,releasing
R2115 T2551 T2550 arg2Of degraded,and
R2116 T2474 T2477 arg1Of NF-κB,present
R2117 T2555 T2553 arg2Of p50/p65,releasing
R2118 T2475 T2468 arg1Of is,However
R2119 T2555 T2554 arg1Of p50/p65,NF-κB
R2120 T2555 T2557 arg1Of p50/p65,translocate
R2121 T2555 T2562 arg1Of p50/p65,transactivate
R2122 T2557 T2558 arg1Of translocate,to
R2123 T2557 T2561 arg1Of translocate,and
R2124 T2560 T2558 arg2Of nucleus,to
R2125 T2560 T2559 arg1Of nucleus,the
R2126 T2475 T2469 arg1Of is,","
R2127 T2561 T2553 arg3Of and,releasing
R2128 T2561 T2556 arg1Of and,to
R2129 T2562 T2561 arg2Of transactivate,and
R2130 T2475 T2470 arg1Of is,unlike
R2131 T2564 T2562 arg2Of genes,transactivate
R2132 T2564 T2563 arg1Of genes,target
R2133 T2475 T2473 arg1Of is,","
R2134 T2475 T2494 arg1Of is,as
R2135 T2567 T2565 arg2Of release,After
R2136 T2567 T2566 arg1Of release,its
R2137 T2567 T2568 arg1Of release,from
R2138 T2475 T2500 arg1Of is,[
R2139 T2569 T2568 arg2Of IκBα,from
R2140 T2477 T2475 arg2Of present,is
R2141 T2572 T2571 arg1Of p65,NF-κB
R2142 T2572 T2573 arg1Of p65,can
R2143 T2572 T2574 arg1Of p65,undergo
R2144 T2574 T2565 arg1Of undergo,After
R2145 T2574 T2570 arg1Of undergo,","
R2146 T2574 T2573 arg2Of undergo,can
R2147 T2477 T2476 arg1Of present,constitutively
R2148 T2576 T2574 arg2Of modification,undergo
R2149 T2576 T2575 arg1Of modification,post-translational
R2150 T2576 T2577 modOf modification,to
R2151 T2477 T2478 arg1Of present,in
R2152 T2578 T2577 arg1Of activate,to
R2153 T2480 T2478 arg2Of nuclei,in
R2154 T2580 T2578 arg2Of transcription,activate
R2155 T2580 T2579 arg1Of transcription,gene
R2156 T2582 T2581 arg1Of role,The
R2157 T2582 T2583 arg1Of role,of
R2158 T2582 T2587 arg1Of role,on
R2159 T2582 T2591 arg1Of role,varies
R2160 T2480 T2479 arg1Of nuclei,the
R2161 T2480 T2481 arg1Of nuclei,of
R2162 T2586 T2583 arg2Of phosphorylation,of
R2163 T2586 T2584 arg1Of phosphorylation,NF-κB
R2164 T2586 T2585 arg1Of phosphorylation,p65
R2165 T2483 T2482 arg1Of monocytes,primary
R2166 T2590 T2587 arg2Of activity,on
R2167 T2590 T2588 arg1Of activity,NF-κB
R2168 T2590 T2589 arg1Of activity,transcriptional
R2169 T2591 T2592 arg1Of varies,by
R2170 T2591 T2601 arg1Of varies,[
R2171 T2483 T2484 arg1Of monocytes,and
R2172 T2593 T2594 arg1Of stimulus,","
R2173 T2484 T2481 arg2Of and,of
R2174 T2594 T2598 arg1Of ",",and
R2175 T2595 T2594 arg2Of time,","
R2176 T2595 T2596 arg1Of time,of
R2177 T2597 T2596 arg2Of stimulation,of
R2178 T2598 T2592 arg2Of and,by
R2179 T2484 T2488 arg1Of and,in
R2180 T2487 T2484 arg2Of lines,and
R2181 T2600 T2598 arg2Of type,and
R2182 T2600 T2599 arg1Of type,cell
R2183 T2602 T2601 arg2Of 16,[
R2184 T2603 T2601 arg3Of ],[
R2185 T2605 T2604 arg1Of research,Previous
R2186 T2605 T2606 arg1Of research,shows
R2187 T2487 T2485 arg1Of lines,monocytic
R2188 T2487 T2486 arg1Of lines,cell
R2189 T2488 T2489 arg1Of in,the
R2190 T2608 T2609 arg1Of phosphorylation,of
R2191 T2608 T2612 arg1Of phosphorylation,at
R2192 T2608 T2618 arg1Of phosphorylation,plays
R2193 T2488 T2491 arg1Of in,of
R2194 T2611 T2609 arg2Of p65,of
R2195 T2611 T2610 arg1Of p65,NF-κB
R2196 T2490 T2488 arg2Of absence,in
R2197 T2613 T2614 arg1Of Ser276,","
R2198 T2614 T2616 arg1Of ",",or
R2199 T2615 T2614 arg2Of Ser529,","
R2200 T2616 T2612 arg2Of or,at
R2201 T2493 T2488 arg3Of stimuli,in
R2202 T2617 T2616 arg2Of Ser536,or
R2203 T2618 T2606 arg2Of plays,shows
R2204 T2618 T2607 arg1Of plays,that
R2205 T2618 T2622 arg1Of plays,in
R2206 T2493 T2492 arg1Of stimuli,exogenous
R2207 T2495 T2494 arg2Of demonstrated,as
R2208 T2621 T2618 arg2Of role,plays
R2209 T2621 T2619 arg1Of role,an
R2210 T2621 T2620 arg1Of role,important
R2211 T2623 T2622 arg2Of regulating,in
R2212 T2623 T2628 arg1Of regulating,[
R2213 T2499 T2495 arg1Of analysis,demonstrated
R2214 T2625 T2623 arg2Of activity,regulating
R2215 T2625 T2624 arg1Of activity,transcriptional
R2216 T2625 T2626 arg1Of activity,of
R2217 T2627 T2626 arg2Of NF-κB,of
R2218 T2629 T2628 arg2Of 17,[
R2219 T2630 T2628 arg3Of ],[
R2220 T2499 T2496 arg2Of analysis,by
R2221 T2499 T2497 arg1Of analysis,mobility
R2222 T2499 T2498 arg1Of analysis,shift
R2223 T2501 T2500 arg2Of 13,[
R2224 T2634 T2631 arg2Of fibroblasts,In
R2225 T2634 T2632 arg1Of fibroblasts,TNFα-treated
R2226 T2634 T2633 arg1Of fibroblasts,murine
R2227 T2502 T2500 arg3Of ],[
R2228 T2636 T2637 arg1Of Ser276,of
R2229 T2636 T2640 arg1Of Ser276,is
R2230 T2636 T2641 arg2Of Ser276,phosphorylated
R2231 T2507 T2505 arg1Of NF-κB,constitutively
R2232 T2639 T2637 arg2Of p65,of
R2233 T2639 T2638 arg1Of p65,NF-κB
R2234 T2641 T2631 arg1Of phosphorylated,In
R2235 T2641 T2635 arg1Of phosphorylated,","
R2236 T2641 T2640 arg2Of phosphorylated,is
R2237 T2641 T2644 modOf phosphorylated,to
R2238 T2643 T2641 arg1Of MSK1,phosphorylated
R2239 T2643 T2642 arg2Of MSK1,by
R2240 T2645 T2644 arg1Of enhance,to
R2241 T2507 T2506 arg1Of NF-κB,active
R2242 T2648 T2645 arg2Of activity,enhance
R2243 T2648 T2646 arg1Of activity,NF-κB
R2244 T2648 T2647 arg1Of activity,transcriptional
R2245 T2648 T2649 arg1Of activity,[
R2246 T2507 T2508 arg1Of NF-κB,was
R2247 T2650 T2649 arg2Of 18,[
R2248 T2651 T2649 arg3Of ],[
R2249 T2507 T2509 arg2Of NF-κB,observed
R2250 T2509 T2503 arg1Of observed,Similarly
R2251 T2653 T2652 arg2Of macrophages,In
R2252 T2653 T2654 arg2Of macrophages,treated
R2253 T2654 T2655 arg1Of treated,with
R2254 T2656 T2655 arg2Of endotoxin,with
R2255 T2509 T2504 arg1Of observed,","
R2256 T2509 T2508 arg2Of observed,was
R2257 T2660 T2658 arg1Of activity,NF-κB
R2258 T2660 T2659 arg1Of activity,transcription
R2259 T2660 T2661 arg1Of activity,is
R2260 T2660 T2662 arg2Of activity,associated
R2261 T2509 T2510 arg1Of observed,in
R2262 T2662 T2652 arg1Of associated,In
R2263 T2662 T2657 arg1Of associated,","
R2264 T2662 T2661 arg2Of associated,is
R2265 T2662 T2663 arg1Of associated,with
R2266 T2509 T2514 arg1Of observed,[
R2267 T2664 T2663 arg2Of phosphorylation,with
R2268 T2664 T2665 arg1Of phosphorylation,on
R2269 T2513 T2510 arg2Of macrophages,in
R2270 T2666 T2667 arg1Of Ser276,and
R2271 T2667 T2665 arg2Of and,on
R2272 T2667 T2669 arg1Of and,that
R2273 T2667 T2670 arg1Of and,is
R2274 T2667 T2671 arg2Of and,regulated
R2275 T2668 T2667 arg2Of Ser536,and
R2276 T2671 T2670 arg2Of regulated,is
R2277 T2671 T2672 arg1Of regulated,through
R2278 T2671 T2682 arg1Of regulated,[
R2279 T2671 T2685 arg1Of regulated,","
R2280 T2671 T2686 arg1Of regulated,[
R2281 T2675 T2673 arg1Of A,protein
R2282 T2675 T2674 arg1Of A,kinase
R2283 T2675 T2676 arg1Of A,(
R2284 T2675 T2679 arg1Of A,and
R2285 T2513 T2511 arg1Of macrophages,human
R2286 T2677 T2676 arg2Of PKA,(
R2287 T2513 T2512 arg1Of macrophages,alveolar
R2288 T2678 T2676 arg3Of ),(
R2289 T2679 T2672 arg2Of and,through
R2290 T2679 T2681 arg1Of and,respectively
R2291 T2515 T2514 arg2Of 14,[
R2292 T2680 T2679 arg2Of IKKβ,and
R2293 T2683 T2682 arg2Of 16,[
R2294 T2516 T2514 arg3Of ],[
R2295 T2684 T2682 arg3Of ],[
R2296 T2520 T2517 arg2Of pathway,In
R2297 T2687 T2686 arg2Of 19,[
R2298 T2688 T2686 arg3Of ],[
R2299 T2520 T2518 arg1Of pathway,the
R2300 T2692 T2689 arg2Of cells,In
R2301 T2692 T2690 arg1Of cells,human
R2302 T2692 T2691 arg1Of cells,T
R2303 T2520 T2519 arg1Of pathway,classic/canonical
R2304 T2525 T2522 arg1Of complex,the
R2305 T2695 T2694 arg1Of p65,NF-κB
R2306 T2695 T2696 arg1Of p65,is
R2307 T2695 T2698 arg2Of p65,phosphorylated
R2308 T2698 T2689 arg1Of phosphorylated,In
R2309 T2698 T2693 arg1Of phosphorylated,","
R2310 T2698 T2696 arg2Of phosphorylated,is
R2311 T2698 T2697 arg1Of phosphorylated,constitutively
R2312 T2698 T2699 arg1Of phosphorylated,on
R2313 T2698 T2701 modOf phosphorylated,to
R2314 T2698 T2710 arg1Of phosphorylated,[
R2315 T2525 T2523 arg1Of complex,NF-κB
R2316 T2700 T2699 arg2Of Ser536,on
R2317 T2525 T2524 arg1Of complex,p50/p65
R2318 T2525 T2526 arg1Of complex,is
R2319 T2702 T2701 arg1Of facilitate,to
R2320 T2702 T2707 arg1Of facilitate,following
R2321 T2525 T2527 arg2Of complex,sequestered
R2322 T2527 T2517 arg1Of sequestered,In
R2323 T2706 T2702 arg2Of translocation,facilitate
R2324 T2706 T2703 arg1Of translocation,NF-κB
R2325 T2706 T2704 arg1Of translocation,p65
R2326 T2706 T2705 arg1Of translocation,nuclear
R2327 T2709 T2707 arg2Of stimulation,following
R2328 T2709 T2708 arg1Of stimulation,cellular
R2329 T2711 T2710 arg2Of 20,[
R2330 T2527 T2521 arg1Of sequestered,","
R2331 T2712 T2710 arg3Of ],[
R2332 T2713 T2715 arg1Of Accumulating,reveals
R2333 T2527 T2526 arg2Of sequestered,is
R2334 T2714 T2713 arg2Of evidence,Accumulating
R2335 T2527 T2528 arg1Of sequestered,in
R2336 T2530 T2528 arg2Of cytosol,in
R2337 T2719 T2717 arg1Of phosphorylation,NF-κB
R2338 T2719 T2718 arg1Of phosphorylation,p65
R2339 T2719 T2720 arg1Of phosphorylation,at
R2340 T2719 T2722 arg1Of phosphorylation,is
R2341 T2719 T2723 arg1Of phosphorylation,crucial
R2342 T2721 T2720 arg2Of Ser276,at
R2343 T2722 T2715 arg2Of is,reveals
R2344 T2722 T2716 arg1Of is,that
R2345 T2530 T2529 arg1Of cytosol,the
R2346 T2723 T2722 arg2Of crucial,is
R2347 T2723 T2724 arg1Of crucial,for
R2348 T2530 T2531 arg1Of cytosol,by
R2349 T2532 T2531 arg2Of IκBα,by
R2350 T2727 T2724 arg2Of activity,for
R2351 T2727 T2725 arg1Of activity,its
R2352 T2727 T2726 arg1Of activity,transcriptional
R2353 T2532 T2533 arg1Of IκBα,[
R2354 T2827 T2824 arg2Of activation,in
R2355 T2827 T2825 arg1Of activation,M-CSF-stimulated
R2356 T2827 T2826 arg1Of activation,NF-κB
R2357 T2730 T2728 arg2Of translocation,Upon
R2358 T2730 T2729 arg1Of translocation,nuclear
R2359 T2829 T2828 arg1Of proteins,PKC
R2360 T2732 T2733 arg1Of phosphorylation,of
R2361 T2732 T2735 arg1Of phosphorylation,on
R2362 T2732 T2740 arg1Of phosphorylation,recruits
R2363 T2734 T2733 arg2Of Ser276,of
R2364 T2829 T2830 arg1Of proteins,are
R2365 T2832 T2830 arg2Of kinases,are
R2366 T2737 T2735 arg2Of p65,on
R2367 T2737 T2736 arg1Of p65,NF-κB
R2368 T2737 T2738 arg1Of p65,by
R2369 T2739 T2738 arg2Of PKA,by
R2370 T2740 T2728 arg1Of recruits,Upon
R2371 T2740 T2731 arg1Of recruits,","
R2372 T2740 T2751 arg1Of recruits,[
R2373 T2832 T2831 arg1Of kinases,multifunctional
R2374 T2743 T2740 arg2Of co-activator,recruits
R2375 T2743 T2741 arg1Of co-activator,the
R2376 T2743 T2742 arg1Of co-activator,transcription
R2377 T2743 T2744 arg1Of co-activator,","
R2378 T2745 T2744 arg2Of p300,","
R2379 T2745 T2746 modOf p300,to
R2380 T2747 T2746 arg1Of potentiate,to
R2381 T2832 T2833 arg1Of kinases,that
R2382 T2832 T2834 arg1Of kinases,differ
R2383 T2834 T2835 arg1Of differ,in
R2384 T2750 T2747 arg2Of transcription,potentiate
R2385 T2750 T2748 arg1Of transcription,NF-κB-regulated
R2386 T2750 T2749 arg1Of transcription,gene
R2387 T2752 T2751 arg2Of 21,[
R2388 T2753 T2751 arg3Of ],[
R2389 T2836 T2837 arg1Of structure,","
R2390 T2757 T2756 arg1Of studies,other
R2391 T2757 T2758 arg1Of studies,show
R2392 T2758 T2754 arg1Of show,However
R2393 T2758 T2755 arg1Of show,","
R2394 T2837 T2839 arg1Of ",",and
R2395 T2760 T2761 arg1Of PKA,inhibits
R2396 T2760 T2766 arg1Of PKA,stabilizing
R2397 T2761 T2758 arg2Of inhibits,show
R2398 T2761 T2759 arg1Of inhibits,that
R2399 T2761 T2765 arg1Of inhibits,by
R2400 T2838 T2837 arg2Of function,","
R2401 T2764 T2761 arg2Of expression,inhibits
R2402 T2764 T2762 arg1Of expression,NF-κB-regulated
R2403 T2764 T2763 arg1Of expression,gene
R2404 T2839 T2835 arg2Of and,in
R2405 T2766 T2765 arg2Of stabilizing,by
R2406 T2767 T2766 arg2Of IκBα,stabilizing
R2407 T2767 T2768 arg1Of IκBα,[
R2408 T2841 T2839 arg2Of requirement,and
R2409 T2767 T2771 arg1Of IκBα,","
R2410 T2767 T2772 arg1Of IκBα,[
R2411 T2769 T2768 arg2Of 22,[
R2412 T2841 T2840 arg1Of requirement,co-factor
R2413 T2770 T2768 arg3Of ],[
R2414 T2841 T2842 arg1Of requirement,[
R2415 T2843 T2842 arg2Of 26,[
R2416 T2773 T2772 arg2Of 23,[
R2417 T2774 T2772 arg3Of ],[
R2418 T2844 T2842 arg3Of ],[
R2419 T2845 T2846 arg1Of PKCs,are
R2420 T2780 T2777 arg1Of Pim-1,the
R2421 T2780 T2778 arg1Of Pim-1,serine/threonine
R2422 T2780 T2779 arg1Of Pim-1,kinase
R2423 T2780 T2782 arg1Of Pim-1,phosphorylates
R2424 T2780 T2788 arg1Of Pim-1,stabilizing
R2425 T2782 T2775 arg1Of phosphorylates,Interestingly
R2426 T2782 T2776 arg1Of phosphorylates,","
R2427 T2782 T2781 arg1Of phosphorylates,directly
R2428 T2782 T2785 arg1Of phosphorylates,at
R2429 T2782 T2787 arg1Of phosphorylates,by
R2430 T2784 T2782 arg2Of p65,phosphorylates
R2431 T2784 T2783 arg1Of p65,NF-κB
R2432 T2845 T2847 arg2Of PKCs,involved
R2433 T2786 T2785 arg2Of Ser276,at
R2434 T2847 T2846 arg2Of involved,are
R2435 T2788 T2787 arg2Of stabilizing,by
R2436 T2788 T2789 modOf stabilizing,to
R2437 T2790 T2789 arg1Of prevent,to
R2438 T2847 T2848 arg1Of involved,in
R2439 T2792 T2790 arg2Of degradation,prevent
R2440 T2792 T2791 arg1Of degradation,ubiquitin-proteasome
R2441 T2792 T2793 arg1Of degradation,[
R2442 T2851 T2848 arg2Of responses,in
R2443 T2794 T2793 arg2Of 24,[
R2444 T2795 T2793 arg3Of ],[
R2445 T2797 T2796 arg1Of other,Several
R2446 T2799 T2797 arg1Of sites,other
R2447 T2799 T2798 arg1Of sites,phosphorylation
R2448 T2799 T2800 arg1Of sites,are
R2449 T2799 T2802 arg2Of sites,described
R2450 T2799 T2804 arg1Of sites,enhance
R2451 T2851 T2849 arg1Of responses,diverse
R2452 T2851 T2850 arg1Of responses,cell
R2453 T2802 T2800 arg2Of described,are
R2454 T2802 T2801 arg1Of described,also
R2455 T2851 T2852 arg1Of responses,","
R2456 T2804 T2802 arg3Of enhance,described
R2457 T2804 T2803 arg1Of enhance,to
R2458 T2804 T2808 arg1Of enhance,[
R2459 T2851 T2853 arg1Of responses,including
R2460 T2855 T2854 arg1Of growth,cell
R2461 T2807 T2804 arg2Of transactivation,enhance
R2462 T2807 T2805 arg1Of transactivation,NF-κB
R2463 T2807 T2806 arg1Of transactivation,gene
R2464 T2809 T2808 arg2Of 25,[
R2465 T2810 T2808 arg3Of ],[
R2466 T2813 T2814 arg1Of we,investigate
R2467 T2814 T2811 arg1Of investigate,Here
R2468 T2814 T2812 arg1Of investigate,","
R2469 T2855 T2856 arg1Of growth,","
R2470 T2816 T2814 arg2Of role,investigate
R2471 T2816 T2815 arg1Of role,the
R2472 T2816 T2817 arg1Of role,of
R2473 T2856 T2858 arg1Of ",",","
R2474 T2820 T2817 arg2Of C,of
R2475 T2820 T2818 arg1Of C,protein
R2476 T2820 T2819 arg1Of C,kinase
R2477 T2820 T2821 arg1Of C,(
R2478 T2820 T2824 arg1Of C,in
R2479 T2822 T2821 arg2Of PKC,(
R2480 T2823 T2821 arg3Of ),(
R2481 T2857 T2856 arg2Of survival,","
R2482 T2858 T2860 arg1Of ",",and
R2483 T2859 T2858 arg2Of differentiation,","
R2484 T2860 T2853 arg2Of and,including
R2485 T2861 T2860 arg2Of development,and
R2486 T2861 T2862 arg1Of development,[
R2487 T2923 T2924 arg1Of λ,)
R2488 T2863 T2862 arg2Of 27,[
R2489 T2925 T2918 arg2Of require,:
R2490 T2925 T2919 arg1Of require,ξ
R2491 T2925 T2920 arg1Of require,","
R2492 T2925 T2922 arg1Of require,and
R2493 T2925 T2923 arg1Of require,λ
R2494 T2864 T2862 arg3Of ],[
R2495 T2927 T2928 arg1Of Ca2+,nor
R2496 T2928 T2925 arg2Of nor,require
R2497 T2928 T2926 arg1Of nor,neither
R2498 T2868 T2867 arg1Of related,closely
R2499 T2929 T2928 arg2Of DAG,nor
R2500 T2930 T2931 arg1Of Monocytes,and
R2501 T2931 T2934 arg1Of and,express
R2502 T2932 T2931 arg2Of macrophages,and
R2503 T2869 T2865 arg1Of enzymes,The
R2504 T2934 T2933 arg1Of express,predominantly
R2505 T2869 T2866 arg1Of enzymes,12
R2506 T2937 T2935 arg1Of isoforms,conventional
R2507 T2937 T2936 arg1Of isoforms,PKC
R2508 T2937 T2938 arg1Of isoforms,(
R2509 T2937 T2944 arg1Of isoforms,and
R2510 T2869 T2868 arg1Of enzymes,related
R2511 T2869 T2870 arg1Of enzymes,of
R2512 T2940 T2939 arg1Of PKCβI,PKCα
R2513 T2940 T2941 arg1Of PKCβI,and
R2514 T2869 T2874 arg1Of enzymes,are
R2515 T2941 T2938 arg2Of and,(
R2516 T2869 T2875 arg2Of enzymes,divided
R2517 T2942 T2941 arg2Of PKCβII,and
R2518 T2943 T2938 arg3Of ),(
R2519 T2873 T2870 arg2Of family,of
R2520 T2944 T2934 arg2Of and,express
R2521 T2946 T2944 arg2Of PKCs,and
R2522 T2946 T2945 arg1Of PKCs,novel
R2523 T2946 T2947 arg1Of PKCs,(
R2524 T2948 T2949 arg1Of PKCδ,and
R2525 T2949 T2947 arg2Of and,(
R2526 T2950 T2949 arg2Of PKCε,and
R2527 T2951 T2947 arg3Of ),(
R2528 T2873 T2871 arg1Of family,the
R2529 T2953 T2952 arg1Of PKCs,Conventional
R2530 T2953 T2954 arg1Of PKCs,regulate
R2531 T2873 T2872 arg1Of family,PKC
R2532 T2955 T2954 arg2Of differentiation,regulate
R2533 T2955 T2956 arg1Of differentiation,of
R2534 T2955 T2964 arg1Of differentiation,to
R2535 T2875 T2874 arg2Of divided,are
R2536 T2875 T2876 arg1Of divided,into
R2537 T2875 T2883 arg1Of divided,:
R2538 T2878 T2876 arg2Of classes,into
R2539 T2963 T2956 arg2Of HL60,of
R2540 T2963 T2957 arg1Of HL60,the
R2541 T2963 T2958 arg1Of HL60,human
R2542 T2963 T2959 arg1Of HL60,promyelocytic
R2543 T2963 T2960 arg1Of HL60,leukemia
R2544 T2963 T2961 arg1Of HL60,cell
R2545 T2963 T2962 arg1Of HL60,line
R2546 T2965 T2964 arg2Of macrophages,to
R2547 T2965 T2966 arg1Of macrophages,[
R2548 T2967 T2966 arg2Of 28,[
R2549 T2968 T2966 arg3Of ],[
R2550 T2969 T2970 arg1Of PKCα,induces
R2551 T2878 T2877 arg1Of classes,three
R2552 T2970 T2978 arg1Of induces,after
R2553 T2970 T2984 arg1Of induces,[
R2554 T2971 T2972 arg1Of IL-1α,","
R2555 T2878 T2879 arg1Of classes,:
R2556 T2972 T2974 arg1Of ",",and
R2557 T2882 T2879 arg2Of cPKCs,:
R2558 T2973 T2972 arg2Of iNOS,","
R2559 T2974 T2970 arg2Of and,induces
R2560 T2977 T2974 arg2Of production,and
R2561 T2977 T2975 arg1Of production,TNFα
R2562 T2977 T2976 arg1Of production,mRNA
R2563 T2979 T2980 arg1Of lipopolysaccharide,(
R2564 T2882 T2880 arg1Of cPKCs,conventional
R2565 T2981 T2980 arg2Of LPS,(
R2566 T2882 T2881 arg1Of cPKCs,(
R2567 T2982 T2980 arg3Of ),(
R2568 T2886 T2885 arg1Of βII,βI
R2569 T2983 T2978 arg2Of exposure,after
R2570 T2983 T2979 arg1Of exposure,lipopolysaccharide
R2571 T2985 T2984 arg2Of 29,[
R2572 T2986 T2984 arg3Of ],[
R2573 T2988 T2987 arg2Of addition,In
R2574 T2886 T2887 arg1Of βII,and
R2575 T2990 T2992 arg1Of accumulating,suggests
R2576 T2991 T2990 arg2Of evidence,accumulating
R2577 T2992 T2987 arg1Of suggests,In
R2578 T2992 T2989 arg1Of suggests,","
R2579 T2887 T2884 arg1Of and,α
R2580 T2995 T2994 arg1Of PKCs,conventional
R2581 T2995 T2996 arg1Of PKCs,like
R2582 T2995 T2998 arg1Of PKCs,have
R2583 T2887 T2889 arg1Of and,require
R2584 T2997 T2996 arg2Of PKCα,like
R2585 T2888 T2887 arg2Of γ,and
R2586 T2998 T2992 arg2Of have,suggests
R2587 T2998 T2993 arg1Of have,that
R2588 T3000 T2998 arg2Of functions,have
R2589 T2889 T2883 arg2Of require,:
R2590 T3000 T2999 arg1Of functions,anti-apoptotic
R2591 T2889 T2900 arg1Of require,:
R2592 T2890 T2891 arg1Of Ca2+,and
R2593 T3002 T3001 arg2Of example,For
R2594 T2891 T2889 arg2Of and,require
R2595 T3004 T3005 arg1Of PKCα,is
R2596 T3004 T3006 arg2Of PKCα,overexpressed
R2597 T3006 T3001 arg1Of overexpressed,For
R2598 T3006 T3003 arg1Of overexpressed,","
R2599 T3006 T3005 arg2Of overexpressed,is
R2600 T3006 T3007 arg1Of overexpressed,in
R2601 T2891 T2893 arg1Of and,(
R2602 T2891 T2896 arg1Of and,;
R2603 T3009 T3007 arg2Of variety,in
R2604 T3009 T3008 arg1Of variety,a
R2605 T3009 T3010 arg1Of variety,of
R2606 T2892 T2891 arg2Of diacylglycerol,and
R2607 T3012 T3010 arg2Of cells,of
R2608 T3012 T3011 arg1Of cells,tumor
R2609 T3012 T3013 arg1Of cells,including
R2610 T2894 T2893 arg2Of DAG,(
R2611 T3014 T3015 arg1Of gliomas,","
R2612 T3015 T3018 arg1Of ",",and
R2613 T3016 T3015 arg2Of liver,","
R2614 T2895 T2893 arg3Of ),(
R2615 T3018 T3013 arg2Of and,including
R2616 T3018 T3017 arg1Of and,","
R2617 T3018 T3023 arg1Of and,","
R2618 T3018 T3024 arg1Of and,[
R2619 T2899 T2896 arg2Of nPKCs,;
R2620 T3019 T3018 arg2Of lung,and
R2621 T3019 T3020 arg1Of lung,[
R2622 T2899 T2897 arg1Of nPKCs,novel
R2623 T3021 T3020 arg2Of 30,[
R2624 T2899 T2898 arg1Of nPKCs,(
R2625 T3022 T3020 arg3Of ],[
R2626 T2907 T2911 arg1Of θ,require
R2627 T3025 T3024 arg2Of 31,[
R2628 T3026 T3024 arg3Of ],[
R2629 T3029 T3027 arg2Of cells,In
R2630 T3029 T3028 arg1Of cells,epithelial
R2631 T3031 T3032 arg1Of inhibition,of
R2632 T3031 T3034 arg1Of inhibition,induces
R2633 T3033 T3032 arg2Of PKCα,of
R2634 T3034 T3027 arg1Of induces,In
R2635 T3034 T3030 arg1Of induces,","
R2636 T3036 T3034 arg2Of apoptosis,induces
R2637 T3036 T3035 arg1Of apoptosis,PKCδ-dependent
R2638 T3036 T3037 arg1Of apoptosis,[
R2639 T2909 T2910 arg1Of μ,)
R2640 T3038 T3037 arg2Of 31,[
R2641 T3039 T3037 arg3Of ],[
R2642 T2911 T2874 modOf require,are
R2643 T3044 T3043 arg1Of monocytes,human
R2644 T3044 T3045 arg1Of monocytes,and
R2645 T2911 T2901 arg1Of require,δ
R2646 T3045 T3042 arg2Of and,in
R2647 T2911 T2902 arg1Of require,","
R2648 T2911 T2903 arg1Of require,ε
R2649 T2911 T2904 arg1Of require,","
R2650 T2911 T2905 arg1Of require,η
R2651 T3049 T3045 arg2Of cells,and
R2652 T3049 T3046 arg1Of cells,premonocytic
R2653 T3049 T3047 arg1Of cells,THP-1
R2654 T3049 T3048 arg1Of cells,leukemia
R2655 T2911 T2906 arg1Of require,","
R2656 T2911 T2908 arg1Of require,and
R2657 T3052 T3051 arg1Of PKCs,novel
R2658 T3052 T3053 arg1Of PKCs,like
R2659 T3052 T3055 arg1Of PKCs,have
R2660 T2911 T2909 arg1Of require,μ
R2661 T3054 T3053 arg2Of PKCδ,like
R2662 T2911 T2912 arg1Of require,DAG
R2663 T3055 T3059 arg1Of have,on
R2664 T3055 T3062 arg1Of have,","
R2665 T2911 T2915 arg1Of require,atypical
R2666 T2912 T2914 arg1Of DAG,and
R2667 T3058 T3055 arg2Of effect,have
R2668 T3058 T3056 arg1Of effect,the
R2669 T3058 T3057 arg1Of effect,opposite
R2670 T2914 T2913 arg1Of and,;
R2671 T3061 T3059 arg2Of survival,on
R2672 T3061 T3060 arg1Of survival,cell
R2673 T3062 T3040 arg1Of ",",Interestingly
R2674 T3062 T3041 arg1Of ",",","
R2675 T3062 T3042 arg1Of ",",in
R2676 T3062 T3050 arg1Of ",",","
R2677 T3065 T3063 arg1Of al,Voss
R2678 T3065 T3064 arg1Of al,et
R2679 T3065 T3066 arg1Of al,showed
R2680 T3066 T3062 arg2Of showed,","
R2681 T2915 T2914 arg2Of atypical,and
R2682 T3068 T3070 arg1Of PKCδ,phosphorylates
R2683 T3068 T3073 arg1Of PKCδ,promotes
R2684 T3070 T3069 arg1Of phosphorylates,directly
R2685 T3070 T3072 arg1Of phosphorylates,and
R2686 T2917 T2911 arg2Of aPKCs,require
R2687 T3071 T3070 arg2Of caspase-3,phosphorylates
R2688 T3072 T3066 arg2Of and,showed
R2689 T3072 T3067 arg1Of and,that
R2690 T3073 T3072 arg2Of promotes,and
R2691 T3075 T3073 arg2Of apoptosis,promotes
R2692 T3075 T3074 arg1Of apoptosis,etoposide-induced
R2693 T2917 T2916 arg1Of aPKCs,(
R2694 T2917 T2918 arg1Of aPKCs,:
R2695 T3075 T3076 arg1Of apoptosis,[
R2696 T2921 T2925 arg1Of ι,require
R2697 T3077 T3076 arg2Of 32,[
R2698 T3078 T3076 arg3Of ],[
R2699 T3119 T3116 arg2Of pathway,of
R2700 T3083 T3081 arg1Of studies,knockout
R2701 T3083 T3082 arg1Of studies,mouse
R2702 T3083 T3084 arg1Of studies,suggest
R2703 T3084 T3079 arg1Of suggest,Moreover
R2704 T3084 T3080 arg1Of suggest,","
R2705 T3088 T3086 arg1Of PKC,another
R2706 T3088 T3087 arg1Of PKC,novel
R2707 T3088 T3089 arg1Of PKC,","
R2708 T3088 T3091 arg1Of PKC,is
R2709 T3088 T3093 arg2Of PKC,involved
R2710 T3090 T3089 arg2Of PKCε,","
R2711 T3119 T3117 arg1Of pathway,the
R2712 T3093 T3084 arg2Of involved,suggest
R2713 T3093 T3085 arg1Of involved,that
R2714 T3093 T3091 arg2Of involved,is
R2715 T3093 T3092 arg1Of involved,critically
R2716 T3093 T3094 arg1Of involved,in
R2717 T3093 T3101 arg1Of involved,[
R2718 T3119 T3118 arg1Of pathway,PI3-K/AKT
R2719 T3119 T3120 arg1Of pathway,[
R2720 T3121 T3120 arg2Of 3,[
R2721 T3097 T3094 arg2Of signaling,in
R2722 T3097 T3095 arg1Of signaling,early
R2723 T3097 T3096 arg1Of signaling,LPS-mediated
R2724 T3097 T3098 arg1Of signaling,in
R2725 T3100 T3098 arg2Of macrophages,in
R2726 T3100 T3099 arg2Of macrophages,activated
R2727 T3102 T3101 arg2Of 33,[
R2728 T3103 T3101 arg3Of ],[
R2729 T3122 T3120 arg3Of ],[
R2730 T3106 T3107 arg1Of we,reported
R2731 T3107 T3104 arg1Of reported,Previously
R2732 T3107 T3105 arg1Of reported,","
R2733 T3123 T3125 arg1Of In,to
R2734 T3109 T3110 arg1Of M-CSF,promotes
R2735 T3124 T3123 arg2Of addition,In
R2736 T3110 T3107 arg2Of promotes,reported
R2737 T3110 T3108 arg1Of promotes,that
R2738 T3110 T3113 arg1Of promotes,through
R2739 T3112 T3110 arg2Of survival,promotes
R2740 T3112 T3111 arg1Of survival,monocyte
R2741 T3127 T3123 arg3Of activation,In
R2742 T3115 T3113 arg2Of activation,through
R2743 T3115 T3114 arg1Of activation,the
R2744 T3115 T3116 arg1Of activation,of
R2745 T3127 T3126 arg1Of activation,AKT
R2746 T3129 T3130 arg1Of M-CSF,stimulates
R2747 T3129 T3136 arg1Of M-CSF,increases
R2748 T3213 T3210 arg2Of and,of
R2749 T3130 T3132 arg1Of stimulates,in
R2750 T3130 T3135 arg1Of stimulates,and
R2751 T3216 T3213 arg2Of survival,and
R2752 T3216 T3214 arg1Of survival,M-CSF-induced
R2753 T3216 T3215 arg1Of survival,monocyte
R2754 T3131 T3130 arg2Of PKC,stimulates
R2755 T3218 T3219 arg1Of we,demonstrates
R2756 T3219 T3217 arg1Of demonstrates,Here
R2757 T3134 T3132 arg2Of monocytes,in
R2758 T3221 T3222 arg1Of M-CSF,upregulated
R2759 T3222 T3219 arg2Of upregulated,demonstrates
R2760 T3222 T3220 arg1Of upregulated,that
R2761 T3134 T3133 arg1Of monocytes,human
R2762 T3225 T3224 arg1Of transcription,NF-κB
R2763 T3225 T3226 arg1Of transcription,and
R2764 T3135 T3123 arg1Of and,In
R2765 T3226 T3222 arg2Of and,upregulated
R2766 T3226 T3223 arg1Of and,the
R2767 T3135 T3128 arg1Of and,","
R2768 T3226 T3229 arg1Of and,in
R2769 T3136 T3135 arg2Of increases,and
R2770 T3228 T3226 arg2Of survival,and
R2771 T3228 T3227 arg1Of survival,cell
R2772 T3136 T3140 arg1Of increases,[
R2773 T3139 T3136 arg2Of binding,increases
R2774 T3233 T3229 arg2Of macrophages,in
R2775 T3233 T3230 arg1Of macrophages,human
R2776 T3233 T3231 arg1Of macrophages,and
R2777 T3233 T3232 arg1Of macrophages,mouse
R2778 T3235 T3234 arg1Of activity,This
R2779 T3235 T3236 arg1Of activity,was
R2780 T3235 T3237 arg2Of activity,reduced
R2781 T3237 T3236 arg2Of reduced,was
R2782 T3139 T3137 arg1Of binding,NF-κB
R2783 T3240 T3242 arg1Of conventional,but
R2784 T3139 T3138 arg1Of binding,DNA
R2785 T3141 T3140 arg2Of 34,[
R2786 T3242 T3241 arg1Of but,","
R2787 T3244 T3242 arg2Of novel,but
R2788 T3244 T3243 arg1Of novel,not
R2789 T3142 T3140 arg3Of ],[
R2790 T3247 T3240 arg1Of inhibitors,conventional
R2791 T3146 T3147 arg1Of PKC,and/or
R2792 T3247 T3244 arg1Of inhibitors,novel
R2793 T3247 T3245 arg1Of inhibitors,","
R2794 T3247 T3246 arg1Of inhibitors,PKC
R2795 T3247 T3248 arg1Of inhibitors,","
R2796 T3248 T3253 arg1Of ",",or
R2797 T3147 T3150 arg1Of and/or,is
R2798 T3252 T3248 arg2Of constructs,","
R2799 T3252 T3249 arg1Of constructs,dominant
R2800 T3252 T3250 arg1Of constructs,negative
R2801 T3252 T3251 arg1Of constructs,PKCα
R2802 T3253 T3237 arg1Of or,reduced
R2803 T3253 T3238 arg2Of or,by
R2804 T3253 T3239 arg1Of or,the
R2805 T3255 T3253 arg2Of siRNA,or
R2806 T3255 T3254 arg1Of siRNA,PKCα
R2807 T3147 T3151 arg1Of and/or,critical
R2808 T3149 T3147 arg2Of activation,and/or
R2809 T3257 T3256 arg1Of PKC,Conventional
R2810 T3257 T3258 arg1Of PKC,regulated
R2811 T3149 T3148 arg1Of activation,NF-κB
R2812 T3261 T3259 arg1Of expression,NF-κB-regulated
R2813 T3261 T3260 arg1Of expression,gene
R2814 T3261 T3262 arg1Of expression,and
R2815 T3262 T3269 arg1Of and,occurred
R2816 T3263 T3262 arg2Of phosphorylation,and
R2817 T3263 T3264 arg1Of phosphorylation,of
R2818 T3150 T3145 arg1Of is,whether
R2819 T3265 T3264 arg2Of Ser276,of
R2820 T3265 T3266 arg1Of Ser276,of
R2821 T3150 T3159 arg1Of is,is
R2822 T3268 T3266 arg2Of p65,of
R2823 T3268 T3267 arg1Of p65,NF-κB
R2824 T3150 T3160 arg1Of is,unclear
R2825 T3269 T3258 arg2Of occurred,regulated
R2826 T3269 T3270 arg1Of occurred,in
R2827 T3151 T3150 arg2Of critical,is
R2828 T3273 T3270 arg2Of fashion,in
R2829 T3273 T3271 arg1Of fashion,an
R2830 T3273 T3272 arg1Of fashion,M-CSF-dependent
R2831 T3273 T3274 arg1Of fashion,correlating
R2832 T3274 T3275 arg1Of correlating,with
R2833 T3151 T3152 arg1Of critical,in
R2834 T3156 T3153 arg1Of survival,M-CSF-stimulated
R2835 T3279 T3275 arg2Of activity,with
R2836 T3279 T3276 arg1Of activity,its
R2837 T3279 T3277 arg1Of activity,maximal
R2838 T3279 T3278 arg1Of activity,transcriptional
R2839 T3283 T3282 arg1Of phosphorylation,PKCα-regulated
R2840 T3283 T3284 arg1Of phosphorylation,of
R2841 T3283 T3289 arg1Of phosphorylation,plays
R2842 T3283 T3294 arg1Of phosphorylation,regulating
R2843 T3285 T3284 arg2Of Ser276,of
R2844 T3285 T3286 arg1Of Ser276,of
R2845 T3156 T3154 arg1Of survival,mononuclear
R2846 T3288 T3286 arg2Of p65,of
R2847 T3288 T3287 arg1Of p65,NF-κB
R2848 T3156 T3155 arg1Of survival,phagocyte
R2849 T3289 T3280 arg1Of plays,Furthermore
R2850 T3289 T3281 arg1Of plays,","
R2851 T3289 T3293 arg1Of plays,in
R2852 T3156 T3157 arg1Of survival,and/or
R2853 T3157 T3152 arg2Of and/or,in
R2854 T3292 T3289 arg2Of role,plays
R2855 T3292 T3290 arg1Of role,an
R2856 T3292 T3291 arg1Of role,important
R2857 T3294 T3293 arg2Of regulating,in
R2858 T3158 T3157 arg2Of differentiation,and/or
R2859 T3296 T3294 arg2Of activity,regulating
R2860 T3296 T3295 arg1Of activity,its
R2861 T3296 T3297 arg1Of activity,in
R2862 T3159 T3143 arg1Of is,However
R2863 T3299 T3298 arg1Of phagocytes,mononuclear
R2864 T3299 T3300 arg1Of phagocytes,and
R2865 T3300 T3297 arg2Of and,in
R2866 T3159 T3144 arg1Of is,","
R2867 T3160 T3159 arg2Of unclear,is
R2868 T3303 T3300 arg2Of fibroblasts,and
R2869 T3303 T3301 arg1Of fibroblasts,murine
R2870 T3163 T3161 arg2Of cells,In
R2871 T3303 T3302 arg1Of fibroblasts,embryonic
R2872 T3163 T3162 arg1Of cells,other
R2873 T3165 T3166 arg1Of PKC,plays
R2874 T3166 T3161 arg1Of plays,In
R2875 T3166 T3164 arg1Of plays,","
R2876 T3166 T3170 arg1Of plays,in
R2877 T3166 T3179 arg1Of plays,","
R2879 T3169 T3166 arg2Of role,plays
R2881 T3169 T3167 arg1Of role,an
R2882 T3169 T3168 arg1Of role,important
R2883 T3172 T3171 arg1Of activation,NF-κB
R2884 T3172 T3173 arg1Of activation,and
R2885 T3173 T3170 arg2Of and,in
R2886 T3175 T3173 arg2Of survival,and
R2887 T3175 T3174 arg1Of survival,cell
R2888 T3175 T3176 arg1Of survival,[
R2889 T3177 T3176 arg2Of 35,[
R2890 T3178 T3176 arg3Of ],[
R2891 T3183 T3181 arg1Of mechanisms,the
R2892 T3183 T3182 arg1Of mechanisms,specific
R2893 T3183 T3184 arg1Of mechanisms,of
R2894 T3183 T3191 arg1Of mechanisms,on
R2895 T3183 T3194 arg1Of mechanisms,are
R2896 T3183 T3196 arg2Of mechanisms,known
R2897 T3186 T3185 arg1Of activation,this
R2898 T3186 T3187 arg1Of activation,and
R2899 T3187 T3184 arg2Of and,of
R2900 T3190 T3187 arg2Of effects,and
R2901 T3190 T3188 arg1Of effects,the
R2902 T3190 T3189 arg1Of effects,biological
R2903 T3193 T3191 arg2Of phenotype,on
R2904 T3193 T3192 arg1Of phenotype,cellular
R2905 T3196 T3179 arg2Of known,","
R2906 T3196 T3180 arg1Of known,however
R2907 T3196 T3194 arg2Of known,are
R2908 T3196 T3195 arg1Of known,not
R2909 T3199 T3200 arg1Of we,focused
R2910 T3200 T3197 arg1Of focused,Therefore
R2911 T3200 T3198 arg1Of focused,","
R2912 T3200 T3201 arg1Of focused,at
R2913 T3202 T3201 arg2Of understanding,at
R2914 T3204 T3202 arg2Of role,understanding
R2915 T3204 T3203 arg1Of role,the
R2916 T3204 T3205 arg1Of role,of
R2917 T3204 T3207 arg1Of role,in
R2918 T3206 T3205 arg2Of PKC,of
R2919 T3209 T3207 arg2Of regulation,in
R2920 T3209 T3208 arg1Of regulation,the
R2921 T3209 T3210 arg1Of regulation,of
R2922 T3212 T3211 arg1Of activation,NF-κB
R2923 T3212 T3213 arg1Of activation,and
R11828 T15744 T15745 arg1Of important,in

sentences

Id Subject Object Predicate Lexical cue
T968 13-98 Sentence denotes Monocytes are produced in the bone marrow and circulate in blood for 24–48 hours [1].
T969 99-161 Sentence denotes In the absence of serum, monocytes die via apoptosis [1], [2].
T970 162-273 Sentence denotes Macrophage colony-stimulating factor (M-CSF) stimulates mononuclear phagocyte survival and differentiation [3].
T971 274-479 Sentence denotes Importantly, M-CSF-mediated cell survival and activation is associated with a variety of human diseases, including atherosclerosis, transplant vascular sclerosis and breast cancer metastasis [4], [5], [6].
T972 480-579 Sentence denotes We previously identified that NF-κB activation is important in M-CSF-induced monocyte survival [7].
T973 580-821 Sentence denotes In addition to its role in mononuclear phagocyte survival, the transcription factor NF-κB regulates numerous genes that play important roles in cellular signaling, stress response, cell growth, survival, differentiation and inflammation [8].
T974 822-865 Sentence denotes There are five members in the NF-κB family:
T975 866-901 Sentence denotes RelA/p65, p50, p52, c-Rel and RelB.
T976 902-1022 Sentence denotes The most common activating complex is the p50/p65 heterodimer, driven by the activation domain in the NF-κB p65 subunit.
T977 1023-1087 Sentence denotes NF-κB p65 regulates important developmental processes [9], [10].
T978 1088-1183 Sentence denotes Mice lacking NF-κB p65 die in utero and have extensive liver damage via enhanced apoptosis [9].
T979 1184-1335 Sentence denotes Embryonic macrophages from NF-κB p65 null mice are susceptible to TNFα-induced apoptosis which is rescued by overexpressing the NF-κB p65 subunit [10].
T980 1336-1505 Sentence denotes Moreover, inhibiting NF-κB induces cell death in many cell types and cytokine-independent survival is mediated by constitutively active NF-κB in murine macrophages [11].
T981 1506-1641 Sentence denotes In monocytes and macrophages, NF-κB is an important transcriptional factor for expression of cytokines and cell surface receptors [12].
T982 1642-1851 Sentence denotes However, unlike resting T-cells, NF-κB is constitutively present in the nuclei of primary monocytes and monocytic cell lines in the absence of exogenous stimuli as demonstrated by mobility shift analysis [13].
T983 1852-1939 Sentence denotes Similarly, constitutively active NF-κB was observed in human alveolar macrophages [14].
T984 1940-2043 Sentence denotes In the classic/canonical pathway, the NF-κB p50/p65 complex is sequestered in the cytosol by IκBα [15].
T985 2044-2229 Sentence denotes Upon stimulation by cytokines or UV radiation, IκBα is phosphorylated, ubiquitinated, and degraded, releasing NF-κB p50/p65 to translocate to the nucleus and transactivate target genes.
T986 2230-2344 Sentence denotes After its release from IκBα, NF-κB p65 can undergo post-translational modification to activate gene transcription.
T987 2345-2476 Sentence denotes The role of NF-κB p65 phosphorylation on NF-κB transcriptional activity varies by stimulus, time of stimulation and cell type [16].
T988 2477-2640 Sentence denotes Previous research shows that phosphorylation of NF-κB p65 at Ser276, Ser529 or Ser536 plays an important role in regulating transcriptional activity of NF-κB [17].
T989 2641-2770 Sentence denotes In TNFα-treated murine fibroblasts, Ser276 of NF-κB p65 is phosphorylated by MSK1 to enhance NF-κB transcriptional activity [18].
T990 2771-2976 Sentence denotes In macrophages treated with endotoxin, NF-κB transcription activity is associated with phosphorylation on Ser276 and Ser536 that is regulated through protein kinase A (PKA) and IKKβ respectively[16], [19].
T991 2977-3130 Sentence denotes In human T cells, NF-κB p65 is constitutively phosphorylated on Ser536 to facilitate NF-κB p65 nuclear translocation following cellular stimulation [20].
T992 3131-3246 Sentence denotes Accumulating evidence reveals that NF-κB p65 phosphorylation at Ser276 is crucial for its transcriptional activity.
T993 3247-3421 Sentence denotes Upon nuclear translocation, phosphorylation of Ser276 on NF-κB p65 by PKA recruits the transcription co-activator, p300 to potentiate NF-κB-regulated gene transcription [21].
T994 3422-3531 Sentence denotes However, other studies show that PKA inhibits NF-κB-regulated gene expression by stabilizing IκBα [22], [23].
T995 3532-3689 Sentence denotes Interestingly, the serine/threonine kinase Pim-1 directly phosphorylates NF-κB p65 at Ser276 by stabilizing to prevent ubiquitin-proteasome degradation [24].
T996 3690-3788 Sentence denotes Several other phosphorylation sites are also described to enhance NF-κB gene transactivation [25].
T997 3789-3882 Sentence denotes Here, we investigate the role of protein kinase C (PKC) in M-CSF-stimulated NF-κB activation.
T998 3883-3990 Sentence denotes PKC proteins are multifunctional kinases that differ in structure, function and co-factor requirement [26].
T999 3991-4106 Sentence denotes PKCs are involved in diverse cell responses, including cell growth, survival, differentiation and development [27].
T1000 4107-4370 Sentence denotes The 12 closely related enzymes of the PKC family are divided into three classes: conventional (cPKCs: α βI βII and γ require Ca2+ and diacylglycerol (DAG); novel (nPKCs: δ, ε, η, θ and μ) require DAG; and atypical (aPKCs: ξ, ι and λ) require neither Ca2+ nor DAG.
T1001 4371-4500 Sentence denotes Monocytes and macrophages predominantly express conventional PKC isoforms (PKCα PKCβI and PKCβII) and novel PKCs (PKCδ and PKCε).
T1002 4501-4615 Sentence denotes Conventional PKCs regulate differentiation of the human promyelocytic leukemia cell line HL60 to macrophages [28].
T1003 4616-4711 Sentence denotes PKCα induces IL-1α, iNOS and TNFα mRNA production after lipopolysaccharide (LPS) exposure [29].
T1004 4712-4819 Sentence denotes In addition, accumulating evidence suggests that conventional PKCs like PKCα have anti-apoptotic functions.
T1005 4820-4929 Sentence denotes For example, PKCα is overexpressed in a variety of tumor cells including gliomas, liver, and lung [30], [31].
T1006 4930-5008 Sentence denotes In epithelial cells, inhibition of PKCα induces PKCδ-dependent apoptosis [31].
T1007 5009-5254 Sentence denotes Interestingly, in human monocytes and premonocytic THP-1 leukemia cells, novel PKCs like PKCδ have the opposite effect on cell survival, Voss et al showed that PKCδ directly phosphorylates caspase-3 and promotes etoposide-induced apoptosis [32].
T1008 5255-5410 Sentence denotes Moreover, knockout mouse studies suggest that another novel PKC, PKCε is critically involved in early LPS-mediated signaling in activated macrophages [33].
T1009 5411-5525 Sentence denotes Previously, we reported that M-CSF promotes monocyte survival through the activation of the PI3-K/AKT pathway [3].
T1010 5526-5634 Sentence denotes In addition to AKT activation, M-CSF stimulates PKC in human monocytes and increases NF-κB DNA binding [34].
T1011 5635-5777 Sentence denotes However, whether PKC and/or NF-κB activation is critical in M-CSF-stimulated mononuclear phagocyte survival and/or differentiation is unclear.
T1012 5778-5980 Sentence denotes In other cells, PKC plays an important role in NF-κB activation and cell survival [35], however the specific mechanisms of this activation and the biological effects on cellular phenotype are not known.
T1013 5981-6110 Sentence denotes Therefore, we focused at understanding the role of PKC in the regulation of NF-κB activation and M-CSF-induced monocyte survival.
T1014 6111-6228 Sentence denotes Here we demonstrates that M-CSF upregulated the NF-κB transcription and cell survival in human and mouse macrophages.
T1015 6229-6355 Sentence denotes This activity was reduced by the conventional, but not novel, PKC inhibitors, dominant negative PKCα constructs or PKCα siRNA.
T1016 6356-6551 Sentence denotes Conventional PKC regulated NF-κB-regulated gene expression and phosphorylation of Ser276 of NF-κB p65 occurred in an M-CSF-dependent fashion correlating with its maximal transcriptional activity.
T1017 6552-6729 Sentence denotes Furthermore, PKCα-regulated phosphorylation of Ser276 of NF-κB p65 plays an important role in regulating its activity in mononuclear phagocytes and murine embryonic fibroblasts.
T10 0-12 Sentence denotes Introduction
T11 13-98 Sentence denotes Monocytes are produced in the bone marrow and circulate in blood for 24–48 hours [1].
T12 99-161 Sentence denotes In the absence of serum, monocytes die via apoptosis [1], [2].
T13 162-273 Sentence denotes Macrophage colony-stimulating factor (M-CSF) stimulates mononuclear phagocyte survival and differentiation [3].
T14 274-479 Sentence denotes Importantly, M-CSF-mediated cell survival and activation is associated with a variety of human diseases, including atherosclerosis, transplant vascular sclerosis and breast cancer metastasis [4], [5], [6].
T15 480-579 Sentence denotes We previously identified that NF-κB activation is important in M-CSF-induced monocyte survival [7].
T16 580-821 Sentence denotes In addition to its role in mononuclear phagocyte survival, the transcription factor NF-κB regulates numerous genes that play important roles in cellular signaling, stress response, cell growth, survival, differentiation and inflammation [8].
T17 822-865 Sentence denotes There are five members in the NF-κB family:
T18 866-901 Sentence denotes RelA/p65, p50, p52, c-Rel and RelB.
T19 902-1022 Sentence denotes The most common activating complex is the p50/p65 heterodimer, driven by the activation domain in the NF-κB p65 subunit.
T20 1023-1087 Sentence denotes NF-κB p65 regulates important developmental processes [9], [10].
T21 1088-1183 Sentence denotes Mice lacking NF-κB p65 die in utero and have extensive liver damage via enhanced apoptosis [9].
T22 1184-1335 Sentence denotes Embryonic macrophages from NF-κB p65 null mice are susceptible to TNFα-induced apoptosis which is rescued by overexpressing the NF-κB p65 subunit [10].
T23 1336-1505 Sentence denotes Moreover, inhibiting NF-κB induces cell death in many cell types and cytokine-independent survival is mediated by constitutively active NF-κB in murine macrophages [11].
T24 1506-1641 Sentence denotes In monocytes and macrophages, NF-κB is an important transcriptional factor for expression of cytokines and cell surface receptors [12].
T25 1642-1851 Sentence denotes However, unlike resting T-cells, NF-κB is constitutively present in the nuclei of primary monocytes and monocytic cell lines in the absence of exogenous stimuli as demonstrated by mobility shift analysis [13].
T26 1852-1939 Sentence denotes Similarly, constitutively active NF-κB was observed in human alveolar macrophages [14].
T27 1940-2043 Sentence denotes In the classic/canonical pathway, the NF-κB p50/p65 complex is sequestered in the cytosol by IκBα [15].
T28 2044-2229 Sentence denotes Upon stimulation by cytokines or UV radiation, IκBα is phosphorylated, ubiquitinated, and degraded, releasing NF-κB p50/p65 to translocate to the nucleus and transactivate target genes.
T29 2230-2344 Sentence denotes After its release from IκBα, NF-κB p65 can undergo post-translational modification to activate gene transcription.
T30 2345-2476 Sentence denotes The role of NF-κB p65 phosphorylation on NF-κB transcriptional activity varies by stimulus, time of stimulation and cell type [16].
T31 2477-2640 Sentence denotes Previous research shows that phosphorylation of NF-κB p65 at Ser276, Ser529 or Ser536 plays an important role in regulating transcriptional activity of NF-κB [17].
T32 2641-2770 Sentence denotes In TNFα-treated murine fibroblasts, Ser276 of NF-κB p65 is phosphorylated by MSK1 to enhance NF-κB transcriptional activity [18].
T33 2771-2976 Sentence denotes In macrophages treated with endotoxin, NF-κB transcription activity is associated with phosphorylation on Ser276 and Ser536 that is regulated through protein kinase A (PKA) and IKKβ respectively[16], [19].
T34 2977-3130 Sentence denotes In human T cells, NF-κB p65 is constitutively phosphorylated on Ser536 to facilitate NF-κB p65 nuclear translocation following cellular stimulation [20].
T35 3131-3246 Sentence denotes Accumulating evidence reveals that NF-κB p65 phosphorylation at Ser276 is crucial for its transcriptional activity.
T36 3247-3421 Sentence denotes Upon nuclear translocation, phosphorylation of Ser276 on NF-κB p65 by PKA recruits the transcription co-activator, p300 to potentiate NF-κB-regulated gene transcription [21].
T37 3422-3531 Sentence denotes However, other studies show that PKA inhibits NF-κB-regulated gene expression by stabilizing IκBα [22], [23].
T38 3532-3689 Sentence denotes Interestingly, the serine/threonine kinase Pim-1 directly phosphorylates NF-κB p65 at Ser276 by stabilizing to prevent ubiquitin-proteasome degradation [24].
T39 3690-3788 Sentence denotes Several other phosphorylation sites are also described to enhance NF-κB gene transactivation [25].
T40 3789-3882 Sentence denotes Here, we investigate the role of protein kinase C (PKC) in M-CSF-stimulated NF-κB activation.
T41 3883-3990 Sentence denotes PKC proteins are multifunctional kinases that differ in structure, function and co-factor requirement [26].
T42 3991-4106 Sentence denotes PKCs are involved in diverse cell responses, including cell growth, survival, differentiation and development [27].
T43 4107-4370 Sentence denotes The 12 closely related enzymes of the PKC family are divided into three classes: conventional (cPKCs: α βI βII and γ require Ca2+ and diacylglycerol (DAG); novel (nPKCs: δ, ε, η, θ and μ) require DAG; and atypical (aPKCs: ξ, ι and λ) require neither Ca2+ nor DAG.
T44 4371-4500 Sentence denotes Monocytes and macrophages predominantly express conventional PKC isoforms (PKCα PKCβI and PKCβII) and novel PKCs (PKCδ and PKCε).
T45 4501-4615 Sentence denotes Conventional PKCs regulate differentiation of the human promyelocytic leukemia cell line HL60 to macrophages [28].
T46 4616-4711 Sentence denotes PKCα induces IL-1α, iNOS and TNFα mRNA production after lipopolysaccharide (LPS) exposure [29].
T47 4712-4819 Sentence denotes In addition, accumulating evidence suggests that conventional PKCs like PKCα have anti-apoptotic functions.
T48 4820-4929 Sentence denotes For example, PKCα is overexpressed in a variety of tumor cells including gliomas, liver, and lung [30], [31].
T49 4930-5008 Sentence denotes In epithelial cells, inhibition of PKCα induces PKCδ-dependent apoptosis [31].
T50 5009-5254 Sentence denotes Interestingly, in human monocytes and premonocytic THP-1 leukemia cells, novel PKCs like PKCδ have the opposite effect on cell survival, Voss et al showed that PKCδ directly phosphorylates caspase-3 and promotes etoposide-induced apoptosis [32].
T51 5255-5410 Sentence denotes Moreover, knockout mouse studies suggest that another novel PKC, PKCε is critically involved in early LPS-mediated signaling in activated macrophages [33].
T52 5411-5525 Sentence denotes Previously, we reported that M-CSF promotes monocyte survival through the activation of the PI3-K/AKT pathway [3].
T53 5526-5634 Sentence denotes In addition to AKT activation, M-CSF stimulates PKC in human monocytes and increases NF-κB DNA binding [34].
T54 5635-5777 Sentence denotes However, whether PKC and/or NF-κB activation is critical in M-CSF-stimulated mononuclear phagocyte survival and/or differentiation is unclear.
T55 5778-5980 Sentence denotes In other cells, PKC plays an important role in NF-κB activation and cell survival [35], however the specific mechanisms of this activation and the biological effects on cellular phenotype are not known.
T56 5981-6110 Sentence denotes Therefore, we focused at understanding the role of PKC in the regulation of NF-κB activation and M-CSF-induced monocyte survival.
T57 6111-6228 Sentence denotes Here we demonstrates that M-CSF upregulated the NF-κB transcription and cell survival in human and mouse macrophages.
T58 6229-6355 Sentence denotes This activity was reduced by the conventional, but not novel, PKC inhibitors, dominant negative PKCα constructs or PKCα siRNA.
T59 6356-6551 Sentence denotes Conventional PKC regulated NF-κB-regulated gene expression and phosphorylation of Ser276 of NF-κB p65 occurred in an M-CSF-dependent fashion correlating with its maximal transcriptional activity.
T60 6552-6729 Sentence denotes Furthermore, PKCα-regulated phosphorylation of Ser276 of NF-κB p65 plays an important role in regulating its activity in mononuclear phagocytes and murine embryonic fibroblasts.

2_test

Id Subject Object Predicate Lexical cue
22216091-355567-90609669 95-96 355567 denotes 1
22216091-355567-90609670 153-154 355567 denotes 1
22216091-1940344-90609671 158-159 1940344 denotes 2
22216091-10473597-90609672 270-271 10473597 denotes 3
22216091-15289345-90609673 466-467 15289345 denotes 4
22216091-8633015-90609674 471-472 8633015 denotes 5
22216091-7667279-90609675 476-477 7667279 denotes 6
22216091-11804874-90609676 576-577 11804874 denotes 7
22216091-12464174-90609677 818-819 12464174 denotes 8
22216091-15897281-90609678 1078-1079 15897281 denotes 9
22216091-9299587-90609679 1083-1085 9299587 denotes 10
22216091-15897281-90609680 1180-1181 15897281 denotes 9
22216091-9299587-90609681 1331-1333 9299587 denotes 10
22216091-11073986-90609682 1501-1503 11073986 denotes 11
22216091-8717528-90609683 1637-1639 8717528 denotes 12
22216091-7998962-90609684 1847-1849 7998962 denotes 13
22216091-9878123-90609685 1935-1937 9878123 denotes 14
22216091-17072321-90609686 2039-2041 17072321 denotes 15
22216091-9150141-90609687 2472-2474 9150141 denotes 16
22216091-15122352-90609688 2636-2638 15122352 denotes 17
22216091-12628924-90609689 2766-2768 12628924 denotes 18
22216091-9150141-90609690 2966-2968 9150141 denotes 16
22216091-17405917-90609691 2972-2974 17405917 denotes 19
22216091-16105840-90609692 3126-3128 16105840 denotes 20
22216091-11931769-90609693 3417-3419 11931769 denotes 21
22216091-7744006-90609694 3521-3523 7744006 denotes 22
22216091-19911008-90609695 3685-3687 19911008 denotes 24
22216091-11983155-90609696 3784-3786 11983155 denotes 25
22216091-12495431-90609697 3986-3988 12495431 denotes 26
22216091-17922632-90609698 4102-4104 17922632 denotes 27
22216091-9369943-90609699 4611-4613 9369943 denotes 28
22216091-9830023-90609700 4707-4709 9830023 denotes 29
22216091-17582782-90609701 4919-4921 17582782 denotes 30
22216091-12700627-90609702 4925-4927 12700627 denotes 31
22216091-12700627-90609703 5004-5006 12700627 denotes 31
22216091-15716280-90609704 5250-5252 15716280 denotes 32
22216091-11696589-90609705 5406-5408 11696589 denotes 33
22216091-10473597-90609706 5522-5523 10473597 denotes 3
22216091-1883525-90609707 5630-5632 1883525 denotes 34
22216091-19273207-90609708 5861-5863 19273207 denotes 35

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T1018 13-22 NNS denotes Monocytes
T1019 23-26 VBP denotes are
T1020 27-35 VBN denotes produced
T1021 36-38 IN denotes in
T1022 39-42 DT denotes the
T1023 43-47 NN denotes bone
T1024 48-54 NN denotes marrow
T1025 55-58 CC denotes and
T1026 59-68 VBP denotes circulate
T1027 69-71 IN denotes in
T1028 72-77 NN denotes blood
T1029 78-81 IN denotes for
T1030 82-84 CD denotes 24
T1031 85-87 CD denotes 48
T1032 88-93 NNS denotes hours
T1033 94-95 NNP denotes [
T1034 95-96 CD denotes 1
T1035 96-97 NNP denotes ]
T1036 97-98 . denotes .
T1037 99-101 IN denotes In
T1038 102-105 DT denotes the
T1039 106-113 NN denotes absence
T1040 114-116 IN denotes of
T1041 117-122 NN denotes serum
T1042 122-123 , denotes ,
T1043 124-133 NNS denotes monocytes
T1044 134-137 VBP denotes die
T1045 138-141 IN denotes via
T1046 142-151 NN denotes apoptosis
T1047 152-153 NN denotes [
T1048 153-154 CD denotes 1
T1049 154-155 NNP denotes ]
T1050 155-156 , denotes ,
T1051 157-158 NNP denotes [
T1052 158-159 CD denotes 2
T1053 159-160 NNP denotes ]
T1054 160-161 . denotes .
T1055 162-172 NNP denotes Macrophage
T1056 173-191 JJ denotes colony-stimulating
T1057 192-198 NN denotes factor
T1058 199-200 -LRB- denotes (
T1059 200-205 NNP denotes M-CSF
T1060 205-206 -RRB- denotes )
T1061 207-217 VBZ denotes stimulates
T1062 218-229 JJ denotes mononuclear
T1063 230-239 JJ denotes phagocyte
T1064 240-248 NN denotes survival
T1065 249-252 CC denotes and
T1066 253-268 NN denotes differentiation
T1067 269-270 NN denotes [
T1068 270-271 CD denotes 3
T1069 271-272 NNP denotes ]
T1070 272-273 . denotes .
T1071 274-285 RB denotes Importantly
T1072 285-286 , denotes ,
T1073 287-301 JJ denotes M-CSF-mediated
T1074 302-306 NN denotes cell
T1075 307-315 NN denotes survival
T1076 316-319 CC denotes and
T1077 320-330 NN denotes activation
T1078 331-333 VBZ denotes is
T1079 334-344 VBN denotes associated
T1080 345-349 IN denotes with
T1081 350-351 DT denotes a
T1082 352-359 NN denotes variety
T1083 360-362 IN denotes of
T1084 363-368 JJ denotes human
T1085 369-377 NNS denotes diseases
T1086 377-378 , denotes ,
T1087 379-388 VBG denotes including
T1088 389-404 NN denotes atherosclerosis
T1089 404-405 , denotes ,
T1090 406-416 NN denotes transplant
T1091 417-425 JJ denotes vascular
T1092 426-435 NN denotes sclerosis
T1093 436-439 CC denotes and
T1094 440-446 NN denotes breast
T1095 447-453 NN denotes cancer
T1096 454-464 NN denotes metastasis
T1097 465-466 NNP denotes [
T1098 466-467 CD denotes 4
T1099 467-468 NNP denotes ]
T1100 468-469 , denotes ,
T1101 470-471 NNP denotes [
T1102 471-472 CD denotes 5
T1103 472-473 NNP denotes ]
T1104 473-474 , denotes ,
T1105 475-476 NNP denotes [
T1106 476-477 CD denotes 6
T1107 477-478 NNP denotes ]
T1108 478-479 . denotes .
T1109 480-482 PRP denotes We
T1110 483-493 RB denotes previously
T1111 494-504 VBD denotes identified
T1112 505-509 IN denotes that
T1113 510-515 JJ denotes NF-κB
T1114 516-526 NN denotes activation
T1115 527-529 VBZ denotes is
T1116 530-539 JJ denotes important
T1117 540-542 IN denotes in
T1118 543-556 JJ denotes M-CSF-induced
T1119 557-565 NN denotes monocyte
T1120 566-574 NN denotes survival
T1121 575-576 NN denotes [
T1122 576-577 CD denotes 7
T1123 577-578 NNP denotes ]
T1124 578-579 . denotes .
T1125 580-582 IN denotes In
T1126 583-591 NN denotes addition
T1127 592-594 TO denotes to
T1128 595-598 PRP$ denotes its
T1129 599-603 NN denotes role
T1130 604-606 IN denotes in
T1131 607-618 NN denotes mononuclear
T1132 619-628 JJ denotes phagocyte
T1133 629-637 NN denotes survival
T1134 637-638 , denotes ,
T1135 639-642 DT denotes the
T1136 643-656 NN denotes transcription
T1137 657-663 NN denotes factor
T1138 664-669 NNP denotes NF-κB
T1139 670-679 VBZ denotes regulates
T1140 680-688 JJ denotes numerous
T1141 689-694 NNS denotes genes
T1142 695-699 WDT denotes that
T1143 700-704 VBP denotes play
T1144 705-714 JJ denotes important
T1145 715-720 NNS denotes roles
T1146 721-723 IN denotes in
T1147 724-732 JJ denotes cellular
T1148 733-742 VBG denotes signaling
T1149 742-743 , denotes ,
T1150 744-750 NN denotes stress
T1151 751-759 NN denotes response
T1152 759-760 , denotes ,
T1153 761-765 NN denotes cell
T1154 766-772 NN denotes growth
T1155 772-773 , denotes ,
T1156 774-782 NN denotes survival
T1157 782-783 , denotes ,
T1158 784-799 NN denotes differentiation
T1159 800-803 CC denotes and
T1160 804-816 NN denotes inflammation
T1161 817-818 NN denotes [
T1162 818-819 CD denotes 8
T1163 819-820 NNP denotes ]
T1164 820-821 . denotes .
T1165 822-827 EX denotes There
T1166 828-831 VBP denotes are
T1167 832-836 CD denotes five
T1168 837-844 NNS denotes members
T1169 845-847 IN denotes in
T1170 848-851 DT denotes the
T1171 852-857 NNP denotes NF-κB
T1172 858-864 NN denotes family
T1173 864-865 : denotes :
T1174 866-874 NNS denotes RelA/p65
T1175 874-875 , denotes ,
T1176 876-879 CD denotes p50
T1177 879-880 , denotes ,
T1178 881-884 CD denotes p52
T1179 884-885 , denotes ,
T1180 886-891 NNP denotes c-Rel
T1181 892-895 CC denotes and
T1182 896-900 NNP denotes RelB
T1183 900-901 . denotes .
T1184 902-905 DT denotes The
T1185 906-910 RBS denotes most
T1186 911-917 JJ denotes common
T1187 918-928 NN denotes activating
T1188 929-936 NN denotes complex
T1189 937-939 VBZ denotes is
T1190 940-943 DT denotes the
T1191 944-951 CD denotes p50/p65
T1192 952-963 NN denotes heterodimer
T1193 963-964 , denotes ,
T1194 965-971 VBN denotes driven
T1195 972-974 IN denotes by
T1196 975-978 DT denotes the
T1197 979-989 NN denotes activation
T1198 990-996 NN denotes domain
T1199 997-999 IN denotes in
T1200 1000-1003 DT denotes the
T1201 1004-1009 NNP denotes NF-κB
T1202 1010-1013 CD denotes p65
T1203 1014-1021 NN denotes subunit
T1204 1021-1022 . denotes .
T1205 1023-1028 NNP denotes NF-κB
T1206 1029-1032 CD denotes p65
T1207 1033-1042 VBZ denotes regulates
T1208 1043-1052 JJ denotes important
T1209 1053-1066 JJ denotes developmental
T1210 1067-1076 NNS denotes processes
T1211 1077-1078 VBP denotes [
T1212 1078-1079 CD denotes 9
T1213 1079-1080 NNP denotes ]
T1214 1080-1081 , denotes ,
T1215 1082-1083 NNP denotes [
T1216 1083-1085 CD denotes 10
T1217 1085-1086 NNP denotes ]
T1218 1086-1087 . denotes .
T1219 1088-1092 NNP denotes Mice
T1220 1093-1100 VBG denotes lacking
T1221 1101-1106 NNP denotes NF-κB
T1222 1107-1110 CD denotes p65
T1223 1111-1114 NN denotes die
T1224 1115-1117 IN denotes in
T1225 1118-1123 NN denotes utero
T1226 1124-1127 CC denotes and
T1227 1128-1132 VBP denotes have
T1228 1133-1142 JJ denotes extensive
T1229 1143-1148 NN denotes liver
T1230 1149-1155 NN denotes damage
T1231 1156-1159 IN denotes via
T1232 1160-1168 JJ denotes enhanced
T1233 1169-1178 NN denotes apoptosis
T1234 1179-1180 NN denotes [
T1235 1180-1181 CD denotes 9
T1236 1181-1182 NNP denotes ]
T1237 1182-1183 . denotes .
T1238 1184-1193 JJ denotes Embryonic
T1239 1194-1205 NNS denotes macrophages
T1240 1206-1210 IN denotes from
T1241 1211-1216 NNP denotes NF-κB
T1242 1217-1220 CD denotes p65
T1243 1221-1225 NN denotes null
T1244 1226-1230 NNS denotes mice
T1245 1231-1234 VBP denotes are
T1246 1235-1246 JJ denotes susceptible
T1247 1247-1249 TO denotes to
T1248 1250-1262 JJ denotes TNFα-induced
T1249 1263-1272 NN denotes apoptosis
T1250 1273-1278 WDT denotes which
T1251 1279-1281 VBZ denotes is
T1252 1282-1289 VBN denotes rescued
T1253 1290-1292 IN denotes by
T1254 1293-1307 VBG denotes overexpressing
T1255 1308-1311 DT denotes the
T1256 1312-1317 NNP denotes NF-κB
T1257 1318-1321 CD denotes p65
T1258 1322-1329 VBN denotes subunit
T1259 1330-1331 NNP denotes [
T1260 1331-1333 CD denotes 10
T1261 1333-1334 NNP denotes ]
T1262 1334-1335 . denotes .
T1263 1336-1344 RB denotes Moreover
T1264 1344-1345 , denotes ,
T1265 1346-1356 VBG denotes inhibiting
T1266 1357-1362 JJ denotes NF-κB
T1267 1363-1370 VBZ denotes induces
T1268 1371-1375 NN denotes cell
T1269 1376-1381 NN denotes death
T1270 1382-1384 IN denotes in
T1271 1385-1389 JJ denotes many
T1272 1390-1394 NN denotes cell
T1273 1395-1400 NNS denotes types
T1274 1401-1404 CC denotes and
T1275 1405-1425 JJ denotes cytokine-independent
T1276 1426-1434 NN denotes survival
T1277 1435-1437 VBZ denotes is
T1278 1438-1446 VBN denotes mediated
T1279 1447-1449 IN denotes by
T1280 1450-1464 RB denotes constitutively
T1281 1465-1471 JJ denotes active
T1282 1472-1477 NN denotes NF-κB
T1283 1478-1480 IN denotes in
T1284 1481-1487 JJ denotes murine
T1285 1488-1499 NNS denotes macrophages
T1286 1500-1501 NNP denotes [
T1287 1501-1503 CD denotes 11
T1288 1503-1504 NNP denotes ]
T1289 1504-1505 . denotes .
T1290 1506-1508 IN denotes In
T1291 1509-1518 NNS denotes monocytes
T1292 1519-1522 CC denotes and
T1293 1523-1534 NNS denotes macrophages
T1294 1534-1535 , denotes ,
T1295 1536-1541 NN denotes NF-κB
T1296 1542-1544 VBZ denotes is
T1297 1545-1547 DT denotes an
T1298 1548-1557 JJ denotes important
T1299 1558-1573 JJ denotes transcriptional
T1300 1574-1580 NN denotes factor
T1301 1581-1584 IN denotes for
T1302 1585-1595 NN denotes expression
T1303 1596-1598 IN denotes of
T1304 1599-1608 NNS denotes cytokines
T1305 1609-1612 CC denotes and
T1306 1613-1617 NN denotes cell
T1307 1618-1625 NN denotes surface
T1308 1626-1635 NNS denotes receptors
T1309 1636-1637 NNP denotes [
T1310 1637-1639 CD denotes 12
T1311 1639-1640 NNP denotes ]
T1312 1640-1641 . denotes .
T1313 1642-1649 RB denotes However
T1314 1649-1650 , denotes ,
T1315 1651-1657 IN denotes unlike
T1316 1658-1665 VBG denotes resting
T1317 1666-1673 NNS denotes T-cells
T1318 1673-1674 , denotes ,
T1319 1675-1680 NN denotes NF-κB
T1320 1681-1683 VBZ denotes is
T1321 1684-1698 RB denotes constitutively
T1322 1699-1706 JJ denotes present
T1323 1707-1709 IN denotes in
T1324 1710-1713 DT denotes the
T1325 1714-1720 NN denotes nuclei
T1326 1721-1723 IN denotes of
T1327 1724-1731 JJ denotes primary
T1328 1732-1741 NNS denotes monocytes
T1329 1742-1745 CC denotes and
T1330 1746-1755 JJ denotes monocytic
T1331 1756-1760 NN denotes cell
T1332 1761-1766 NNS denotes lines
T1333 1767-1769 IN denotes in
T1334 1770-1773 DT denotes the
T1335 1774-1781 NN denotes absence
T1336 1782-1784 IN denotes of
T1337 1785-1794 JJ denotes exogenous
T1338 1795-1802 NNS denotes stimuli
T1339 1803-1805 IN denotes as
T1340 1806-1818 VBN denotes demonstrated
T1341 1819-1821 IN denotes by
T1342 1822-1830 NN denotes mobility
T1343 1831-1836 NN denotes shift
T1344 1837-1845 NN denotes analysis
T1345 1846-1847 NNP denotes [
T1346 1847-1849 CD denotes 13
T1347 1849-1850 NNP denotes ]
T1348 1850-1851 . denotes .
T1349 1852-1861 RB denotes Similarly
T1350 1861-1862 , denotes ,
T1351 1863-1877 RB denotes constitutively
T1352 1878-1884 JJ denotes active
T1353 1885-1890 NN denotes NF-κB
T1354 1891-1894 VBD denotes was
T1355 1895-1903 VBN denotes observed
T1356 1904-1906 IN denotes in
T1357 1907-1912 JJ denotes human
T1358 1913-1921 JJ denotes alveolar
T1359 1922-1933 NNS denotes macrophages
T1360 1934-1935 NNP denotes [
T1361 1935-1937 CD denotes 14
T1362 1937-1938 NNP denotes ]
T1363 1938-1939 . denotes .
T1364 1940-1942 IN denotes In
T1365 1943-1946 DT denotes the
T1366 1947-1964 JJ denotes classic/canonical
T1367 1965-1972 NN denotes pathway
T1368 1972-1973 , denotes ,
T1369 1974-1977 DT denotes the
T1370 1978-1983 NNP denotes NF-κB
T1371 1984-1991 CD denotes p50/p65
T1372 1992-1999 NN denotes complex
T1373 2000-2002 VBZ denotes is
T1374 2003-2014 VBN denotes sequestered
T1375 2015-2017 IN denotes in
T1376 2018-2021 DT denotes the
T1377 2022-2029 NN denotes cytosol
T1378 2030-2032 IN denotes by
T1379 2033-2037 NNP denotes IκBα
T1380 2038-2039 NNP denotes [
T1381 2039-2041 CD denotes 15
T1382 2041-2042 NNP denotes ]
T1383 2042-2043 . denotes .
T1384 2044-2048 IN denotes Upon
T1385 2049-2060 NN denotes stimulation
T1386 2061-2063 IN denotes by
T1387 2064-2073 NNS denotes cytokines
T1388 2074-2076 CC denotes or
T1389 2077-2079 NN denotes UV
T1390 2080-2089 NN denotes radiation
T1391 2089-2090 , denotes ,
T1392 2091-2095 NNP denotes IκBα
T1393 2096-2098 VBZ denotes is
T1394 2099-2113 VBN denotes phosphorylated
T1395 2113-2114 , denotes ,
T1396 2115-2128 VBN denotes ubiquitinated
T1397 2128-2129 , denotes ,
T1398 2130-2133 CC denotes and
T1399 2134-2142 JJ denotes degraded
T1400 2142-2143 , denotes ,
T1401 2144-2153 VBG denotes releasing
T1402 2154-2159 NNP denotes NF-κB
T1403 2160-2167 CD denotes p50/p65
T1404 2168-2170 TO denotes to
T1405 2171-2182 VB denotes translocate
T1406 2183-2185 TO denotes to
T1407 2186-2189 DT denotes the
T1408 2190-2197 NN denotes nucleus
T1409 2198-2201 CC denotes and
T1410 2202-2215 NN denotes transactivate
T1411 2216-2222 NN denotes target
T1412 2223-2228 NNS denotes genes
T1413 2228-2229 . denotes .
T1414 2230-2235 IN denotes After
T1415 2236-2239 PRP$ denotes its
T1416 2240-2247 NN denotes release
T1417 2248-2252 IN denotes from
T1418 2253-2257 NNP denotes IκBα
T1419 2257-2258 , denotes ,
T1420 2259-2264 NNP denotes NF-κB
T1421 2265-2268 NNS denotes p65
T1422 2269-2272 MD denotes can
T1423 2273-2280 VB denotes undergo
T1424 2281-2299 JJ denotes post-translational
T1425 2300-2312 NN denotes modification
T1426 2313-2315 TO denotes to
T1427 2316-2324 VB denotes activate
T1428 2325-2329 NN denotes gene
T1429 2330-2343 NN denotes transcription
T1430 2343-2344 . denotes .
T1431 2345-2348 DT denotes The
T1432 2349-2353 NN denotes role
T1433 2354-2356 IN denotes of
T1434 2357-2362 NNP denotes NF-κB
T1435 2363-2366 CD denotes p65
T1436 2367-2382 NN denotes phosphorylation
T1437 2383-2385 IN denotes on
T1438 2386-2391 JJ denotes NF-κB
T1439 2392-2407 JJ denotes transcriptional
T1440 2408-2416 NN denotes activity
T1441 2417-2423 VBZ denotes varies
T1442 2424-2426 IN denotes by
T1443 2427-2435 NN denotes stimulus
T1444 2435-2436 , denotes ,
T1445 2437-2441 NN denotes time
T1446 2442-2444 IN denotes of
T1447 2445-2456 NN denotes stimulation
T1448 2457-2460 CC denotes and
T1449 2461-2465 NN denotes cell
T1450 2466-2470 NN denotes type
T1451 2471-2472 NNP denotes [
T1452 2472-2474 CD denotes 16
T1453 2474-2475 NNP denotes ]
T1454 2475-2476 . denotes .
T1455 2477-2485 JJ denotes Previous
T1456 2486-2494 NN denotes research
T1457 2495-2500 VBZ denotes shows
T1458 2501-2505 IN denotes that
T1459 2506-2521 NN denotes phosphorylation
T1460 2522-2524 IN denotes of
T1461 2525-2530 NNP denotes NF-κB
T1462 2531-2534 NNS denotes p65
T1463 2535-2537 IN denotes at
T1464 2538-2544 NNP denotes Ser276
T1465 2544-2545 , denotes ,
T1466 2546-2552 NNP denotes Ser529
T1467 2553-2555 CC denotes or
T1468 2556-2562 NNP denotes Ser536
T1469 2563-2568 VBZ denotes plays
T1470 2569-2571 DT denotes an
T1471 2572-2581 JJ denotes important
T1472 2582-2586 NN denotes role
T1473 2587-2589 IN denotes in
T1474 2590-2600 VBG denotes regulating
T1475 2601-2616 JJ denotes transcriptional
T1476 2617-2625 NN denotes activity
T1477 2626-2628 IN denotes of
T1478 2629-2634 NNP denotes NF-κB
T1479 2635-2636 NNP denotes [
T1480 2636-2638 CD denotes 17
T1481 2638-2639 NNP denotes ]
T1482 2639-2640 . denotes .
T1483 2641-2643 IN denotes In
T1484 2644-2656 JJ denotes TNFα-treated
T1485 2657-2663 NN denotes murine
T1486 2664-2675 NNS denotes fibroblasts
T1487 2675-2676 , denotes ,
T1488 2677-2683 NNP denotes Ser276
T1489 2684-2686 IN denotes of
T1490 2687-2692 NNP denotes NF-κB
T1491 2693-2696 CD denotes p65
T1492 2697-2699 VBZ denotes is
T1493 2700-2714 VBN denotes phosphorylated
T1494 2715-2717 IN denotes by
T1495 2718-2722 CD denotes MSK1
T1496 2723-2725 TO denotes to
T1497 2726-2733 VB denotes enhance
T1498 2734-2739 JJ denotes NF-κB
T1499 2740-2755 JJ denotes transcriptional
T1500 2756-2764 NN denotes activity
T1501 2765-2766 NNP denotes [
T1502 2766-2768 CD denotes 18
T1503 2768-2769 NNP denotes ]
T1504 2769-2770 . denotes .
T1505 2771-2773 IN denotes In
T1506 2774-2785 NNS denotes macrophages
T1507 2786-2793 VBN denotes treated
T1508 2794-2798 IN denotes with
T1509 2799-2808 NN denotes endotoxin
T1510 2808-2809 , denotes ,
T1511 2810-2815 JJ denotes NF-κB
T1512 2816-2829 NN denotes transcription
T1513 2830-2838 NN denotes activity
T1514 2839-2841 VBZ denotes is
T1515 2842-2852 VBN denotes associated
T1516 2853-2857 IN denotes with
T1517 2858-2873 NN denotes phosphorylation
T1518 2874-2876 IN denotes on
T1519 2877-2883 NNP denotes Ser276
T1520 2884-2887 CC denotes and
T1521 2888-2894 NNP denotes Ser536
T1522 2895-2899 WDT denotes that
T1523 2900-2902 VBZ denotes is
T1524 2903-2912 VBN denotes regulated
T1525 2913-2920 IN denotes through
T1526 2921-2928 NN denotes protein
T1527 2929-2935 NN denotes kinase
T1528 2936-2937 DT denotes A
T1529 2938-2939 -LRB- denotes (
T1530 2939-2942 NNP denotes PKA
T1531 2942-2943 -RRB- denotes )
T1532 2944-2947 CC denotes and
T1533 2948-2952 NNP denotes IKKβ
T1534 2953-2965 RB denotes respectively
T1535 2965-2966 NNP denotes [
T1536 2966-2968 CD denotes 16
T1537 2968-2969 NNP denotes ]
T1538 2969-2970 , denotes ,
T1539 2971-2972 NNP denotes [
T1540 2972-2974 CD denotes 19
T1541 2974-2975 NNP denotes ]
T1542 2975-2976 . denotes .
T1543 2977-2979 IN denotes In
T1544 2980-2985 JJ denotes human
T1545 2986-2987 NNP denotes T
T1546 2988-2993 NNS denotes cells
T1547 2993-2994 , denotes ,
T1548 2995-3000 NNP denotes NF-κB
T1549 3001-3004 CD denotes p65
T1550 3005-3007 VBZ denotes is
T1551 3008-3022 RB denotes constitutively
T1552 3023-3037 VBN denotes phosphorylated
T1553 3038-3040 IN denotes on
T1554 3041-3047 CD denotes Ser536
T1555 3048-3050 TO denotes to
T1556 3051-3061 VB denotes facilitate
T1557 3062-3067 NNP denotes NF-κB
T1558 3068-3071 CD denotes p65
T1559 3072-3079 JJ denotes nuclear
T1560 3080-3093 NN denotes translocation
T1561 3094-3103 VBG denotes following
T1562 3104-3112 JJ denotes cellular
T1563 3113-3124 NN denotes stimulation
T1564 3125-3126 NNP denotes [
T1565 3126-3128 CD denotes 20
T1566 3128-3129 NNP denotes ]
T1567 3129-3130 . denotes .
T1568 3131-3143 VBG denotes Accumulating
T1569 3144-3152 NN denotes evidence
T1570 3153-3160 VBZ denotes reveals
T1571 3161-3165 IN denotes that
T1572 3166-3171 NNP denotes NF-κB
T1573 3172-3175 CD denotes p65
T1574 3176-3191 NN denotes phosphorylation
T1575 3192-3194 IN denotes at
T1576 3195-3201 NNP denotes Ser276
T1577 3202-3204 VBZ denotes is
T1578 3205-3212 JJ denotes crucial
T1579 3213-3216 IN denotes for
T1580 3217-3220 PRP$ denotes its
T1581 3221-3236 JJ denotes transcriptional
T1582 3237-3245 NN denotes activity
T1583 3245-3246 . denotes .
T1584 3247-3251 IN denotes Upon
T1585 3252-3259 JJ denotes nuclear
T1586 3260-3273 NN denotes translocation
T1587 3273-3274 , denotes ,
T1588 3275-3290 NN denotes phosphorylation
T1589 3291-3293 IN denotes of
T1590 3294-3300 NNP denotes Ser276
T1591 3301-3303 IN denotes on
T1592 3304-3309 NNP denotes NF-κB
T1593 3310-3313 CD denotes p65
T1594 3314-3316 IN denotes by
T1595 3317-3320 NNP denotes PKA
T1596 3321-3329 VBZ denotes recruits
T1597 3330-3333 DT denotes the
T1598 3334-3347 NN denotes transcription
T1599 3348-3360 NN denotes co-activator
T1600 3360-3361 , denotes ,
T1601 3362-3366 CD denotes p300
T1602 3367-3369 TO denotes to
T1603 3370-3380 VB denotes potentiate
T1604 3381-3396 JJ denotes NF-κB-regulated
T1605 3397-3401 NN denotes gene
T1606 3402-3415 NN denotes transcription
T1607 3416-3417 NNP denotes [
T1608 3417-3419 CD denotes 21
T1609 3419-3420 NNP denotes ]
T1610 3420-3421 . denotes .
T1611 3422-3429 RB denotes However
T1612 3429-3430 , denotes ,
T1613 3431-3436 JJ denotes other
T1614 3437-3444 NNS denotes studies
T1615 3445-3449 VBP denotes show
T1616 3450-3454 IN denotes that
T1617 3455-3458 NNP denotes PKA
T1618 3459-3467 VBZ denotes inhibits
T1619 3468-3483 JJ denotes NF-κB-regulated
T1620 3484-3488 NN denotes gene
T1621 3489-3499 NN denotes expression
T1622 3500-3502 IN denotes by
T1623 3503-3514 VBG denotes stabilizing
T1624 3515-3519 NNP denotes IκBα
T1625 3520-3521 NNP denotes [
T1626 3521-3523 CD denotes 22
T1627 3523-3524 NNP denotes ]
T1628 3524-3525 , denotes ,
T1629 3526-3527 NNP denotes [
T1630 3527-3529 CD denotes 23
T1631 3529-3530 NNP denotes ]
T1632 3530-3531 . denotes .
T1633 3532-3545 RB denotes Interestingly
T1634 3545-3546 , denotes ,
T1635 3547-3550 DT denotes the
T1636 3551-3567 JJ denotes serine/threonine
T1637 3568-3574 NN denotes kinase
T1638 3575-3580 NN denotes Pim-1
T1639 3581-3589 RB denotes directly
T1640 3590-3604 VBZ denotes phosphorylates
T1641 3605-3610 NNP denotes NF-κB
T1642 3611-3614 CD denotes p65
T1643 3615-3617 IN denotes at
T1644 3618-3624 CD denotes Ser276
T1645 3625-3627 IN denotes by
T1646 3628-3639 VBG denotes stabilizing
T1647 3640-3642 TO denotes to
T1648 3643-3650 VB denotes prevent
T1649 3651-3671 JJ denotes ubiquitin-proteasome
T1650 3672-3683 NN denotes degradation
T1651 3684-3685 NNP denotes [
T1652 3685-3687 CD denotes 24
T1653 3687-3688 NNP denotes ]
T1654 3688-3689 . denotes .
T1655 3690-3697 JJ denotes Several
T1656 3698-3703 JJ denotes other
T1657 3704-3719 NN denotes phosphorylation
T1658 3720-3725 NNS denotes sites
T1659 3726-3729 VBP denotes are
T1660 3730-3734 RB denotes also
T1661 3735-3744 VBN denotes described
T1662 3745-3747 TO denotes to
T1663 3748-3755 VB denotes enhance
T1664 3756-3761 JJ denotes NF-κB
T1665 3762-3766 NN denotes gene
T1666 3767-3782 NN denotes transactivation
T1667 3783-3784 NNP denotes [
T1668 3784-3786 CD denotes 25
T1669 3786-3787 NNP denotes ]
T1670 3787-3788 . denotes .
T1671 3789-3793 RB denotes Here
T1672 3793-3794 , denotes ,
T1673 3795-3797 PRP denotes we
T1674 3798-3809 VBP denotes investigate
T1675 3810-3813 DT denotes the
T1676 3814-3818 NN denotes role
T1677 3819-3821 IN denotes of
T1678 3822-3829 NN denotes protein
T1679 3830-3836 NN denotes kinase
T1680 3837-3838 NNP denotes C
T1681 3839-3840 -LRB- denotes (
T1682 3840-3843 NNP denotes PKC
T1683 3843-3844 -RRB- denotes )
T1684 3845-3847 IN denotes in
T1685 3848-3864 NNP denotes M-CSF-stimulated
T1686 3865-3870 NNP denotes NF-κB
T1687 3871-3881 NN denotes activation
T1688 3881-3882 . denotes .
T1689 3883-3886 NNP denotes PKC
T1690 3887-3895 NNS denotes proteins
T1691 3896-3899 VBP denotes are
T1692 3900-3915 JJ denotes multifunctional
T1693 3916-3923 NNS denotes kinases
T1694 3924-3928 WDT denotes that
T1695 3929-3935 VBP denotes differ
T1696 3936-3938 IN denotes in
T1697 3939-3948 NN denotes structure
T1698 3948-3949 , denotes ,
T1699 3950-3958 NN denotes function
T1700 3959-3962 CC denotes and
T1701 3963-3972 NN denotes co-factor
T1702 3973-3984 NN denotes requirement
T1703 3985-3986 NNP denotes [
T1704 3986-3988 CD denotes 26
T1705 3988-3989 NNP denotes ]
T1706 3989-3990 . denotes .
T1707 3991-3995 NNS denotes PKCs
T1708 3996-3999 VBP denotes are
T1709 4000-4008 VBN denotes involved
T1710 4009-4011 IN denotes in
T1711 4012-4019 JJ denotes diverse
T1712 4020-4024 NN denotes cell
T1713 4025-4034 NNS denotes responses
T1714 4034-4035 , denotes ,
T1715 4036-4045 VBG denotes including
T1716 4046-4050 NN denotes cell
T1717 4051-4057 NN denotes growth
T1718 4057-4058 , denotes ,
T1719 4059-4067 NN denotes survival
T1720 4067-4068 , denotes ,
T1721 4069-4084 NN denotes differentiation
T1722 4085-4088 CC denotes and
T1723 4089-4100 NN denotes development
T1724 4101-4102 NNP denotes [
T1725 4102-4104 CD denotes 27
T1726 4104-4105 NNP denotes ]
T1727 4105-4106 . denotes .
T1728 4107-4110 DT denotes The
T1729 4111-4113 CD denotes 12
T1730 4114-4121 RB denotes closely
T1731 4122-4129 JJ denotes related
T1732 4130-4137 NNS denotes enzymes
T1733 4138-4140 IN denotes of
T1734 4141-4144 DT denotes the
T1735 4145-4148 NNP denotes PKC
T1736 4149-4155 NN denotes family
T1737 4156-4159 VBP denotes are
T1738 4160-4167 VBN denotes divided
T1739 4168-4172 IN denotes into
T1740 4173-4178 CD denotes three
T1741 4179-4186 NNS denotes classes
T1742 4186-4187 : denotes :
T1743 4188-4200 JJ denotes conventional
T1744 4201-4202 -LRB- denotes (
T1745 4202-4207 NNS denotes cPKCs
T1746 4207-4208 : denotes :
T1747 4209-4210 VB denotes α
T1748 4211-4213 NNP denotes βI
T1749 4214-4217 NNP denotes βII
T1750 4218-4221 CC denotes and
T1751 4222-4223 NNP denotes γ
T1752 4224-4231 VBP denotes require
T1753 4232-4235 JJ denotes Ca2
T1754 4235-4236 NN denotes +
T1755 4237-4240 CC denotes and
T1756 4241-4255 NN denotes diacylglycerol
T1757 4256-4257 -LRB- denotes (
T1758 4257-4260 NNP denotes DAG
T1759 4260-4261 -RRB- denotes )
T1760 4261-4262 : denotes ;
T1761 4263-4268 NN denotes novel
T1762 4269-4270 -LRB- denotes (
T1763 4270-4275 NNS denotes nPKCs
T1764 4275-4276 : denotes :
T1765 4277-4278 VB denotes δ
T1766 4278-4279 , denotes ,
T1767 4280-4281 VB denotes ε
T1768 4281-4282 , denotes ,
T1769 4283-4284 VB denotes η
T1770 4284-4285 , denotes ,
T1771 4286-4287 VB denotes θ
T1772 4288-4291 CC denotes and
T1773 4292-4293 VB denotes μ
T1774 4293-4294 -RRB- denotes )
T1775 4295-4302 VBP denotes require
T1776 4303-4306 NNP denotes DAG
T1777 4306-4307 : denotes ;
T1778 4308-4311 CC denotes and
T1779 4312-4320 JJ denotes atypical
T1780 4321-4322 -LRB- denotes (
T1781 4322-4327 NNS denotes aPKCs
T1782 4327-4328 : denotes :
T1783 4329-4330 VB denotes ξ
T1784 4330-4331 , denotes ,
T1785 4332-4333 VB denotes ι
T1786 4334-4337 CC denotes and
T1787 4338-4339 VB denotes λ
T1788 4339-4340 -RRB- denotes )
T1789 4341-4348 VBP denotes require
T1790 4349-4356 CC denotes neither
T1791 4357-4360 VBP denotes Ca2
T1792 4360-4361 CD denotes +
T1793 4362-4365 CC denotes nor
T1794 4366-4369 NNP denotes DAG
T1795 4369-4370 . denotes .
T1796 4371-4380 NNS denotes Monocytes
T1797 4381-4384 CC denotes and
T1798 4385-4396 NNS denotes macrophages
T1799 4397-4410 RB denotes predominantly
T1800 4411-4418 VBP denotes express
T1801 4419-4431 JJ denotes conventional
T1802 4432-4435 NNP denotes PKC
T1803 4436-4444 NNS denotes isoforms
T1804 4445-4446 -LRB- denotes (
T1805 4446-4450 NNP denotes PKCα
T1806 4451-4456 NNP denotes PKCβI
T1807 4457-4460 CC denotes and
T1808 4461-4467 NNP denotes PKCβII
T1809 4467-4468 -RRB- denotes )
T1810 4469-4472 CC denotes and
T1811 4473-4478 JJ denotes novel
T1812 4479-4483 NNS denotes PKCs
T1813 4484-4485 -LRB- denotes (
T1814 4485-4489 NNP denotes PKCδ
T1815 4490-4493 CC denotes and
T1816 4494-4498 NNP denotes PKCε
T1817 4498-4499 -RRB- denotes )
T1818 4499-4500 . denotes .
T1819 4501-4513 JJ denotes Conventional
T1820 4514-4518 NNS denotes PKCs
T1821 4519-4527 VB denotes regulate
T1822 4528-4543 NN denotes differentiation
T1823 4544-4546 IN denotes of
T1824 4547-4550 DT denotes the
T1825 4551-4556 JJ denotes human
T1826 4557-4570 JJ denotes promyelocytic
T1827 4571-4579 NN denotes leukemia
T1828 4580-4584 NN denotes cell
T1829 4585-4589 NN denotes line
T1830 4590-4594 CD denotes HL60
T1831 4595-4597 TO denotes to
T1832 4598-4609 NNS denotes macrophages
T1833 4610-4611 NNP denotes [
T1834 4611-4613 CD denotes 28
T1835 4613-4614 NNP denotes ]
T1836 4614-4615 . denotes .
T1837 4616-4620 NNP denotes PKCα
T1838 4621-4628 VBZ denotes induces
T1839 4629-4634 NNP denotes IL-1α
T1840 4634-4635 , denotes ,
T1841 4636-4640 NNP denotes iNOS
T1842 4641-4644 CC denotes and
T1843 4645-4649 NNP denotes TNFα
T1844 4650-4654 NNP denotes mRNA
T1845 4655-4665 NN denotes production
T1846 4666-4671 IN denotes after
T1847 4672-4690 NN denotes lipopolysaccharide
T1848 4691-4692 -LRB- denotes (
T1849 4692-4695 NNP denotes LPS
T1850 4695-4696 -RRB- denotes )
T1851 4697-4705 NN denotes exposure
T1852 4706-4707 NNP denotes [
T1853 4707-4709 CD denotes 29
T1854 4709-4710 NNP denotes ]
T1855 4710-4711 . denotes .
T1856 4712-4714 IN denotes In
T1857 4715-4723 NN denotes addition
T1858 4723-4724 , denotes ,
T1859 4725-4737 VBG denotes accumulating
T1860 4738-4746 NN denotes evidence
T1861 4747-4755 VBZ denotes suggests
T1862 4756-4760 IN denotes that
T1863 4761-4773 JJ denotes conventional
T1864 4774-4778 NNS denotes PKCs
T1865 4779-4783 IN denotes like
T1866 4784-4788 NNP denotes PKCα
T1867 4789-4793 VBP denotes have
T1868 4794-4808 JJ denotes anti-apoptotic
T1869 4809-4818 NNS denotes functions
T1870 4818-4819 . denotes .
T1871 4820-4823 IN denotes For
T1872 4824-4831 NN denotes example
T1873 4831-4832 , denotes ,
T1874 4833-4837 NNP denotes PKCα
T1875 4838-4840 VBZ denotes is
T1876 4841-4854 VBN denotes overexpressed
T1877 4855-4857 IN denotes in
T1878 4858-4859 DT denotes a
T1879 4860-4867 NN denotes variety
T1880 4868-4870 IN denotes of
T1881 4871-4876 NN denotes tumor
T1882 4877-4882 NNS denotes cells
T1883 4883-4892 VBG denotes including
T1884 4893-4900 NNS denotes gliomas
T1885 4900-4901 , denotes ,
T1886 4902-4907 NN denotes liver
T1887 4907-4908 , denotes ,
T1888 4909-4912 CC denotes and
T1889 4913-4917 NN denotes lung
T1890 4918-4919 NNP denotes [
T1891 4919-4921 CD denotes 30
T1892 4921-4922 NNP denotes ]
T1893 4922-4923 , denotes ,
T1894 4924-4925 NNP denotes [
T1895 4925-4927 CD denotes 31
T1896 4927-4928 NNP denotes ]
T1897 4928-4929 . denotes .
T1898 4930-4932 IN denotes In
T1899 4933-4943 JJ denotes epithelial
T1900 4944-4949 NNS denotes cells
T1901 4949-4950 , denotes ,
T1902 4951-4961 NN denotes inhibition
T1903 4962-4964 IN denotes of
T1904 4965-4969 NNP denotes PKCα
T1905 4970-4977 VBZ denotes induces
T1906 4978-4992 JJ denotes PKCδ-dependent
T1907 4993-5002 NN denotes apoptosis
T1908 5003-5004 NNP denotes [
T1909 5004-5006 CD denotes 31
T1910 5006-5007 NNP denotes ]
T1911 5007-5008 . denotes .
T1912 5009-5022 RB denotes Interestingly
T1913 5022-5023 , denotes ,
T1914 5024-5026 IN denotes in
T1915 5027-5032 JJ denotes human
T1916 5033-5042 NNS denotes monocytes
T1917 5043-5046 CC denotes and
T1918 5047-5059 JJ denotes premonocytic
T1919 5060-5065 NN denotes THP-1
T1920 5066-5074 NN denotes leukemia
T1921 5075-5080 NNS denotes cells
T1922 5080-5081 , denotes ,
T1923 5082-5087 NN denotes novel
T1924 5088-5092 NNS denotes PKCs
T1925 5093-5097 IN denotes like
T1926 5098-5102 NNP denotes PKCδ
T1927 5103-5107 VBP denotes have
T1928 5108-5111 DT denotes the
T1929 5112-5120 JJ denotes opposite
T1930 5121-5127 NN denotes effect
T1931 5128-5130 IN denotes on
T1932 5131-5135 NN denotes cell
T1933 5136-5144 NN denotes survival
T1934 5144-5145 , denotes ,
T1935 5146-5150 NNP denotes Voss
T1936 5151-5153 FW denotes et
T1937 5154-5156 FW denotes al
T1938 5157-5163 VBD denotes showed
T1939 5164-5168 IN denotes that
T1940 5169-5173 NNP denotes PKCδ
T1941 5174-5182 RB denotes directly
T1942 5183-5197 VBZ denotes phosphorylates
T1943 5198-5207 JJ denotes caspase-3
T1944 5208-5211 CC denotes and
T1945 5212-5220 VBZ denotes promotes
T1946 5221-5238 JJ denotes etoposide-induced
T1947 5239-5248 NN denotes apoptosis
T1948 5249-5250 NNP denotes [
T1949 5250-5252 CD denotes 32
T1950 5252-5253 NNP denotes ]
T1951 5253-5254 . denotes .
T1952 5255-5263 RB denotes Moreover
T1953 5263-5264 , denotes ,
T1954 5265-5273 NN denotes knockout
T1955 5274-5279 NN denotes mouse
T1956 5280-5287 NNS denotes studies
T1957 5288-5295 VBP denotes suggest
T1958 5296-5300 IN denotes that
T1959 5301-5308 DT denotes another
T1960 5309-5314 NN denotes novel
T1961 5315-5318 NNP denotes PKC
T1962 5318-5319 , denotes ,
T1963 5320-5324 NNP denotes PKCε
T1964 5325-5327 VBZ denotes is
T1965 5328-5338 RB denotes critically
T1966 5339-5347 VBN denotes involved
T1967 5348-5350 IN denotes in
T1968 5351-5356 JJ denotes early
T1969 5357-5369 JJ denotes LPS-mediated
T1970 5370-5379 VBG denotes signaling
T1971 5380-5382 IN denotes in
T1972 5383-5392 VBN denotes activated
T1973 5393-5404 NNS denotes macrophages
T1974 5405-5406 NNP denotes [
T1975 5406-5408 CD denotes 33
T1976 5408-5409 NNP denotes ]
T1977 5409-5410 . denotes .
T1978 5411-5421 RB denotes Previously
T1979 5421-5422 , denotes ,
T1980 5423-5425 PRP denotes we
T1981 5426-5434 VBD denotes reported
T1982 5435-5439 IN denotes that
T1983 5440-5445 NNP denotes M-CSF
T1984 5446-5454 VBZ denotes promotes
T1985 5455-5463 NN denotes monocyte
T1986 5464-5472 NN denotes survival
T1987 5473-5480 IN denotes through
T1988 5481-5484 DT denotes the
T1989 5485-5495 NN denotes activation
T1990 5496-5498 IN denotes of
T1991 5499-5502 DT denotes the
T1992 5503-5512 NN denotes PI3-K/AKT
T1993 5513-5520 NN denotes pathway
T1994 5521-5522 NNP denotes [
T1995 5522-5523 CD denotes 3
T1996 5523-5524 NNP denotes ]
T1997 5524-5525 . denotes .
T1998 5526-5528 IN denotes In
T1999 5529-5537 NN denotes addition
T2000 5538-5540 TO denotes to
T2001 5541-5544 NNP denotes AKT
T2002 5545-5555 NN denotes activation
T2003 5555-5556 , denotes ,
T2004 5557-5562 NNP denotes M-CSF
T2005 5563-5573 VBZ denotes stimulates
T2006 5574-5577 NNP denotes PKC
T2007 5578-5580 IN denotes in
T2008 5581-5586 JJ denotes human
T2009 5587-5596 NNS denotes monocytes
T2010 5597-5600 CC denotes and
T2011 5601-5610 NNS denotes increases
T2012 5611-5616 NNP denotes NF-κB
T2013 5617-5620 NNP denotes DNA
T2014 5621-5628 JJ denotes binding
T2015 5629-5630 NNP denotes [
T2016 5630-5632 CD denotes 34
T2017 5632-5633 NNP denotes ]
T2018 5633-5634 . denotes .
T2019 5635-5642 RB denotes However
T2020 5642-5643 , denotes ,
T2021 5644-5651 IN denotes whether
T2022 5652-5655 NNP denotes PKC
T2023 5656-5662 CC denotes and/or
T2024 5663-5668 NNP denotes NF-κB
T2025 5669-5679 NN denotes activation
T2026 5680-5682 VBZ denotes is
T2027 5683-5691 JJ denotes critical
T2028 5692-5694 IN denotes in
T2029 5695-5711 JJ denotes M-CSF-stimulated
T2030 5712-5723 NN denotes mononuclear
T2031 5724-5733 NN denotes phagocyte
T2032 5734-5742 NN denotes survival
T2033 5743-5749 CC denotes and/or
T2034 5750-5765 NN denotes differentiation
T2035 5766-5768 VBZ denotes is
T2036 5769-5776 JJ denotes unclear
T2037 5776-5777 . denotes .
T2038 5778-5780 IN denotes In
T2039 5781-5786 JJ denotes other
T2040 5787-5792 NNS denotes cells
T2041 5792-5793 , denotes ,
T2042 5794-5797 NNP denotes PKC
T2043 5798-5803 VBZ denotes plays
T2044 5804-5806 DT denotes an
T2045 5807-5816 JJ denotes important
T2046 5817-5821 NN denotes role
T2047 5822-5824 IN denotes in
T2048 5825-5830 JJ denotes NF-κB
T2049 5831-5841 NN denotes activation
T2050 5842-5845 CC denotes and
T2051 5846-5850 NN denotes cell
T2052 5851-5859 NN denotes survival
T2053 5860-5861 NNP denotes [
T2054 5861-5863 CD denotes 35
T2055 5863-5864 NNP denotes ]
T2056 5864-5865 , denotes ,
T2057 5866-5873 RB denotes however
T2058 5874-5877 DT denotes the
T2059 5878-5886 JJ denotes specific
T2060 5887-5897 NNS denotes mechanisms
T2061 5898-5900 IN denotes of
T2062 5901-5905 DT denotes this
T2063 5906-5916 NN denotes activation
T2064 5917-5920 CC denotes and
T2065 5921-5924 DT denotes the
T2066 5925-5935 JJ denotes biological
T2067 5936-5943 NNS denotes effects
T2068 5944-5946 IN denotes on
T2069 5947-5955 JJ denotes cellular
T2070 5956-5965 NN denotes phenotype
T2071 5966-5969 VBP denotes are
T2072 5970-5973 RB denotes not
T2073 5974-5979 VBN denotes known
T2074 5979-5980 . denotes .
T2075 5981-5990 RB denotes Therefore
T2076 5990-5991 , denotes ,
T2077 5992-5994 PRP denotes we
T2078 5995-6002 VBD denotes focused
T2079 6003-6005 IN denotes at
T2080 6006-6019 VBG denotes understanding
T2081 6020-6023 DT denotes the
T2082 6024-6028 NN denotes role
T2083 6029-6031 IN denotes of
T2084 6032-6035 NNP denotes PKC
T2085 6036-6038 IN denotes in
T2086 6039-6042 DT denotes the
T2087 6043-6053 NN denotes regulation
T2088 6054-6056 IN denotes of
T2089 6057-6062 JJ denotes NF-κB
T2090 6063-6073 NN denotes activation
T2091 6074-6077 CC denotes and
T2092 6078-6091 JJ denotes M-CSF-induced
T2093 6092-6100 NN denotes monocyte
T2094 6101-6109 NN denotes survival
T2095 6109-6110 . denotes .
T2096 6111-6115 RB denotes Here
T2097 6116-6118 PRP denotes we
T2098 6119-6131 VBZ denotes demonstrates
T2099 6132-6136 IN denotes that
T2100 6137-6142 NNP denotes M-CSF
T2101 6143-6154 VBD denotes upregulated
T2102 6155-6158 DT denotes the
T2103 6159-6164 JJ denotes NF-κB
T2104 6165-6178 NN denotes transcription
T2105 6179-6182 CC denotes and
T2106 6183-6187 NN denotes cell
T2107 6188-6196 NN denotes survival
T2108 6197-6199 IN denotes in
T2109 6200-6205 JJ denotes human
T2110 6206-6209 CC denotes and
T2111 6210-6215 NN denotes mouse
T2112 6216-6227 NNS denotes macrophages
T2113 6227-6228 . denotes .
T2114 6229-6233 DT denotes This
T2115 6234-6242 NN denotes activity
T2116 6243-6246 VBD denotes was
T2117 6247-6254 VBN denotes reduced
T2118 6255-6257 IN denotes by
T2119 6258-6261 DT denotes the
T2120 6262-6274 JJ denotes conventional
T2121 6274-6275 , denotes ,
T2122 6276-6279 CC denotes but
T2123 6280-6283 RB denotes not
T2124 6284-6289 JJ denotes novel
T2125 6289-6290 , denotes ,
T2126 6291-6294 NNP denotes PKC
T2127 6295-6305 NNS denotes inhibitors
T2128 6305-6306 , denotes ,
T2129 6307-6315 JJ denotes dominant
T2130 6316-6324 JJ denotes negative
T2131 6325-6329 NNP denotes PKCα
T2132 6330-6340 NNS denotes constructs
T2133 6341-6343 CC denotes or
T2134 6344-6348 NNP denotes PKCα
T2135 6349-6354 NNP denotes siRNA
T2136 6354-6355 . denotes .
T2137 6356-6368 JJ denotes Conventional
T2138 6369-6372 NNP denotes PKC
T2139 6373-6382 VBN denotes regulated
T2140 6383-6398 JJ denotes NF-κB-regulated
T2141 6399-6403 NN denotes gene
T2142 6404-6414 NN denotes expression
T2143 6415-6418 CC denotes and
T2144 6419-6434 NN denotes phosphorylation
T2145 6435-6437 IN denotes of
T2146 6438-6444 NNP denotes Ser276
T2147 6445-6447 IN denotes of
T2148 6448-6453 NNP denotes NF-κB
T2149 6454-6457 CD denotes p65
T2150 6458-6466 VBD denotes occurred
T2151 6467-6469 IN denotes in
T2152 6470-6472 DT denotes an
T2153 6473-6488 JJ denotes M-CSF-dependent
T2154 6489-6496 NN denotes fashion
T2155 6497-6508 VBG denotes correlating
T2156 6509-6513 IN denotes with
T2157 6514-6517 PRP$ denotes its
T2158 6518-6525 JJ denotes maximal
T2159 6526-6541 JJ denotes transcriptional
T2160 6542-6550 NN denotes activity
T2161 6550-6551 . denotes .
T2162 6552-6563 RB denotes Furthermore
T2163 6563-6564 , denotes ,
T2164 6565-6579 JJ denotes PKCα-regulated
T2165 6580-6595 NN denotes phosphorylation
T2166 6596-6598 IN denotes of
T2167 6599-6605 NNP denotes Ser276
T2168 6606-6608 IN denotes of
T2169 6609-6614 NNP denotes NF-κB
T2170 6615-6618 CD denotes p65
T2171 6619-6624 VBZ denotes plays
T2172 6625-6627 DT denotes an
T2173 6628-6637 JJ denotes important
T2174 6638-6642 NN denotes role
T2175 6643-6645 IN denotes in
T2176 6646-6656 VBG denotes regulating
T2177 6657-6660 PRP$ denotes its
T2178 6661-6669 NN denotes activity
T2179 6670-6672 IN denotes in
T2180 6673-6684 NN denotes mononuclear
T2181 6685-6695 NNS denotes phagocytes
T2182 6696-6699 CC denotes and
T2183 6700-6706 JJ denotes murine
T2184 6707-6716 JJ denotes embryonic
T2185 6717-6728 NNS denotes fibroblasts
T2186 6728-6729 . denotes .
T14523 530-539 JJ denotes important
T14524 540-542 IN denotes in
R646 T1018 T1020 nsubjpass Monocytes,produced
R647 T1019 T1020 auxpass are,produced
R648 T1020 T1020 ROOT produced,produced
R649 T1021 T1020 prep in,produced
R650 T1022 T1024 det the,marrow
R651 T1023 T1024 compound bone,marrow
R652 T1024 T1021 pobj marrow,in
R653 T1025 T1020 cc and,produced
R654 T1026 T1020 conj circulate,produced
R655 T1027 T1026 prep in,circulate
R656 T1028 T1027 pobj blood,in
R657 T1029 T1026 prep for,circulate
R658 T1030 T1029 pobj 24,for
R659 T1031 T1032 nummod 48,hours
R660 T1032 T1030 appos hours,24
R661 T1033 T1035 nmod [,]
R662 T1034 T1035 nummod 1,]
R663 T1035 T1032 appos ],hours
R664 T1036 T1020 punct .,produced
R665 T1037 T1044 prep In,die
R666 T1038 T1039 det the,absence
R667 T1039 T1037 pobj absence,In
R668 T1040 T1039 prep of,absence
R669 T1041 T1040 pobj serum,of
R670 T1042 T1044 punct ",",die
R671 T1043 T1044 nsubj monocytes,die
R672 T1044 T1044 ROOT die,die
R673 T1045 T1044 prep via,die
R674 T1046 T1047 compound apoptosis,[
R675 T1047 T1045 pobj [,via
R676 T1048 T1049 nummod 1,]
R677 T1049 T1044 advcl ],die
R678 T1050 T1049 punct ",",]
R679 T1051 T1053 nmod [,]
R680 T1052 T1053 nummod 2,]
R681 T1053 T1049 appos ],]
R682 T1054 T1044 punct .,die
R683 T1055 T1057 nmod Macrophage,factor
R684 T1056 T1057 amod colony-stimulating,factor
R685 T1057 T1061 nsubj factor,stimulates
R686 T1058 T1059 punct (,M-CSF
R687 T1059 T1057 appos M-CSF,factor
R688 T1060 T1057 punct ),factor
R689 T1061 T1061 ROOT stimulates,stimulates
R690 T1062 T1064 amod mononuclear,survival
R691 T1063 T1064 amod phagocyte,survival
R692 T1064 T1069 nmod survival,]
R693 T1065 T1064 cc and,survival
R694 T1066 T1067 compound differentiation,[
R695 T1067 T1064 conj [,survival
R696 T1068 T1069 nummod 3,]
R697 T1069 T1061 dobj ],stimulates
R698 T1070 T1061 punct .,stimulates
R699 T1071 T1079 advmod Importantly,associated
R700 T1072 T1079 punct ",",associated
R701 T1073 T1075 amod M-CSF-mediated,survival
R702 T1074 T1075 compound cell,survival
R703 T1075 T1079 nsubjpass survival,associated
R704 T1076 T1075 cc and,survival
R705 T1077 T1075 conj activation,survival
R706 T1078 T1079 auxpass is,associated
R707 T1079 T1079 ROOT associated,associated
R708 T1080 T1079 prep with,associated
R709 T1081 T1082 det a,variety
R710 T1082 T1080 pobj variety,with
R711 T1083 T1082 prep of,variety
R712 T1084 T1085 amod human,diseases
R713 T1085 T1083 pobj diseases,of
R714 T1086 T1085 punct ",",diseases
R715 T1087 T1085 prep including,diseases
R716 T1088 T1087 pobj atherosclerosis,including
R717 T1089 T1088 punct ",",atherosclerosis
R718 T1090 T1092 nmod transplant,sclerosis
R719 T1091 T1092 amod vascular,sclerosis
R720 T1092 T1088 conj sclerosis,atherosclerosis
R721 T1093 T1092 cc and,sclerosis
R722 T1094 T1095 compound breast,cancer
R723 T1095 T1096 compound cancer,metastasis
R724 T1096 T1092 conj metastasis,sclerosis
R725 T1097 T1099 nmod [,]
R726 T1098 T1099 nummod 4,]
R727 T1099 T1088 conj ],atherosclerosis
R728 T1100 T1099 punct ",",]
R729 T1101 T1103 nmod [,]
R730 T1102 T1103 nummod 5,]
R731 T1103 T1099 conj ],]
R732 T1104 T1103 punct ",",]
R733 T1105 T1107 nmod [,]
R734 T1106 T1107 nummod 6,]
R735 T1107 T1103 conj ],]
R736 T1108 T1079 punct .,associated
R737 T1109 T1111 nsubj We,identified
R738 T1110 T1111 advmod previously,identified
R739 T1111 T1111 ROOT identified,identified
R740 T1112 T1115 mark that,is
R741 T1113 T1114 amod NF-κB,activation
R742 T1114 T1115 nsubj activation,is
R743 T1115 T1111 ccomp is,identified
R744 T1116 T1115 acomp important,is
R745 T1117 T1116 prep in,important
R746 T1118 T1120 amod M-CSF-induced,survival
R747 T1119 T1120 compound monocyte,survival
R748 T1120 T1117 pobj survival,in
R749 T1121 T1123 nmod [,]
R750 T1122 T1123 nummod 7,]
R751 T1123 T1115 npadvmod ],is
R752 T1124 T1111 punct .,identified
R753 T1125 T1139 prep In,regulates
R754 T1126 T1125 pobj addition,In
R755 T1127 T1126 prep to,addition
R756 T1128 T1129 poss its,role
R757 T1129 T1127 pobj role,to
R758 T1130 T1129 prep in,role
R759 T1131 T1133 nmod mononuclear,survival
R760 T1132 T1133 amod phagocyte,survival
R761 T1133 T1130 pobj survival,in
R762 T1134 T1129 punct ",",role
R763 T1135 T1137 det the,factor
R764 T1136 T1137 compound transcription,factor
R765 T1137 T1139 nsubj factor,regulates
R766 T1138 T1139 nsubj NF-κB,regulates
R767 T1139 T1139 ROOT regulates,regulates
R768 T1140 T1141 amod numerous,genes
R769 T1141 T1139 dobj genes,regulates
R770 T1142 T1143 nsubj that,play
R771 T1143 T1141 relcl play,genes
R772 T1144 T1145 amod important,roles
R773 T1145 T1143 dobj roles,play
R774 T1146 T1143 prep in,play
R775 T1147 T1148 amod cellular,signaling
R776 T1148 T1146 pobj signaling,in
R777 T1149 T1148 punct ",",signaling
R778 T1150 T1151 compound stress,response
R779 T1151 T1148 conj response,signaling
R780 T1152 T1151 punct ",",response
R781 T1153 T1154 compound cell,growth
R782 T1154 T1151 conj growth,response
R783 T1155 T1154 punct ",",growth
R784 T1156 T1154 conj survival,growth
R785 T1157 T1156 punct ",",survival
R786 T1158 T1156 conj differentiation,survival
R787 T1159 T1158 cc and,differentiation
R788 T1160 T1158 conj inflammation,differentiation
R789 T1161 T1158 conj [,differentiation
R790 T1162 T1163 nummod 8,]
R791 T1163 T1139 npadvmod ],regulates
R792 T1164 T1139 punct .,regulates
R793 T1165 T1166 expl There,are
R794 T1166 T1166 ROOT are,are
R795 T1167 T1168 nummod five,members
R796 T1168 T1166 attr members,are
R797 T1169 T1168 prep in,members
R798 T1170 T1172 det the,family
R799 T1171 T1172 compound NF-κB,family
R800 T1172 T1169 pobj family,in
R801 T1173 T1168 punct :,members
R802 T1174 T1168 appos RelA/p65,members
R803 T1175 T1174 punct ",",RelA/p65
R804 T1176 T1174 appos p50,RelA/p65
R805 T1177 T1176 punct ",",p50
R806 T1178 T1176 appos p52,p50
R807 T1179 T1176 punct ",",p50
R808 T1180 T1176 conj c-Rel,p50
R809 T1181 T1180 cc and,c-Rel
R810 T1182 T1180 conj RelB,c-Rel
R811 T1183 T1166 punct .,are
R812 T1184 T1188 det The,complex
R813 T1185 T1186 advmod most,common
R814 T1186 T1188 amod common,complex
R815 T1187 T1188 compound activating,complex
R816 T1188 T1189 nsubj complex,is
R817 T1189 T1189 ROOT is,is
R818 T1190 T1192 det the,heterodimer
R819 T1191 T1192 nummod p50/p65,heterodimer
R820 T1192 T1189 attr heterodimer,is
R821 T1193 T1192 punct ",",heterodimer
R822 T1194 T1192 acl driven,heterodimer
R823 T1195 T1194 agent by,driven
R824 T1196 T1198 det the,domain
R825 T1197 T1198 compound activation,domain
R826 T1198 T1195 pobj domain,by
R827 T1199 T1198 prep in,domain
R828 T1200 T1203 det the,subunit
R829 T1201 T1203 nmod NF-κB,subunit
R830 T1202 T1203 nummod p65,subunit
R831 T1203 T1199 pobj subunit,in
R832 T1204 T1189 punct .,is
R833 T1205 T1207 nsubj NF-κB,regulates
R834 T1206 T1205 nummod p65,NF-κB
R835 T1207 T1207 ROOT regulates,regulates
R836 T1208 T1210 amod important,processes
R837 T1209 T1210 amod developmental,processes
R838 T1210 T1207 dobj processes,regulates
R839 T1211 T1213 nmod [,]
R840 T1212 T1213 nummod 9,]
R841 T1213 T1217 nmod ],]
R842 T1214 T1213 punct ",",]
R843 T1215 T1217 nmod [,]
R844 T1216 T1217 nummod 10,]
R845 T1217 T1207 npadvmod ],regulates
R846 T1218 T1207 punct .,regulates
R847 T1219 T1219 ROOT Mice,Mice
R848 T1220 T1219 acl lacking,Mice
R849 T1221 T1223 nsubj NF-κB,die
R850 T1222 T1223 nummod p65,die
R851 T1223 T1220 dep die,lacking
R852 T1224 T1223 prep in,die
R853 T1225 T1224 pobj utero,in
R854 T1226 T1223 cc and,die
R855 T1227 T1223 conj have,die
R856 T1228 T1230 amod extensive,damage
R857 T1229 T1230 compound liver,damage
R858 T1230 T1227 dobj damage,have
R859 T1231 T1230 prep via,damage
R860 T1232 T1234 amod enhanced,[
R861 T1233 T1234 compound apoptosis,[
R862 T1234 T1231 pobj [,via
R863 T1235 T1236 nummod 9,]
R864 T1236 T1230 appos ],damage
R865 T1237 T1220 punct .,lacking
R866 T1238 T1239 amod Embryonic,macrophages
R867 T1239 T1245 nsubj macrophages,are
R868 T1240 T1239 prep from,macrophages
R869 T1241 T1244 nmod NF-κB,mice
R870 T1242 T1241 nummod p65,NF-κB
R871 T1243 T1244 amod null,mice
R872 T1244 T1240 pobj mice,from
R873 T1245 T1245 ROOT are,are
R874 T1246 T1245 acomp susceptible,are
R875 T1247 T1246 prep to,susceptible
R876 T1248 T1249 amod TNFα-induced,apoptosis
R877 T1249 T1247 pobj apoptosis,to
R878 T1250 T1252 nsubjpass which,rescued
R879 T1251 T1252 auxpass is,rescued
R880 T1252 T1249 relcl rescued,apoptosis
R881 T1253 T1252 agent by,rescued
R882 T1254 T1253 pcomp overexpressing,by
R883 T1255 T1259 det the,[
R884 T1256 T1259 nmod NF-κB,[
R885 T1257 T1256 nummod p65,NF-κB
R886 T1258 T1259 amod subunit,[
R887 T1259 T1254 dobj [,overexpressing
R888 T1260 T1261 nummod 10,]
R889 T1261 T1254 dobj ],overexpressing
R890 T1262 T1245 punct .,are
R891 T1263 T1267 advmod Moreover,induces
R892 T1264 T1267 punct ",",induces
R893 T1265 T1267 csubj inhibiting,induces
R894 T1266 T1267 nsubj NF-κB,induces
R895 T1267 T1267 ROOT induces,induces
R896 T1268 T1269 compound cell,death
R897 T1269 T1267 dobj death,induces
R898 T1270 T1267 prep in,induces
R899 T1271 T1273 amod many,types
R900 T1272 T1273 compound cell,types
R901 T1273 T1270 pobj types,in
R902 T1274 T1273 cc and,types
R903 T1275 T1276 amod cytokine-independent,survival
R904 T1276 T1273 conj survival,types
R905 T1277 T1278 auxpass is,mediated
R906 T1278 T1267 conj mediated,induces
R907 T1279 T1278 agent by,mediated
R908 T1280 T1281 advmod constitutively,active
R909 T1281 T1282 amod active,NF-κB
R910 T1282 T1279 pobj NF-κB,by
R911 T1283 T1282 prep in,NF-κB
R912 T1284 T1285 compound murine,macrophages
R913 T1285 T1283 pobj macrophages,in
R914 T1286 T1288 quantmod [,]
R915 T1287 T1288 nummod 11,]
R916 T1288 T1282 appos ],NF-κB
R917 T1289 T1267 punct .,induces
R918 T1290 T1296 prep In,is
R919 T1291 T1290 pobj monocytes,In
R920 T1292 T1291 cc and,monocytes
R921 T1293 T1291 conj macrophages,monocytes
R922 T1294 T1296 punct ",",is
R923 T1295 T1296 nsubj NF-κB,is
R924 T1296 T1296 ROOT is,is
R925 T1297 T1300 det an,factor
R926 T1298 T1300 amod important,factor
R927 T1299 T1300 amod transcriptional,factor
R928 T1300 T1296 attr factor,is
R929 T1301 T1300 prep for,factor
R930 T1302 T1301 pobj expression,for
R931 T1303 T1302 prep of,expression
R932 T1304 T1303 pobj cytokines,of
R933 T1305 T1304 cc and,cytokines
R934 T1306 T1307 compound cell,surface
R935 T1307 T1308 compound surface,receptors
R936 T1308 T1304 conj receptors,cytokines
R937 T1309 T1311 nmod [,]
R938 T1310 T1311 nummod 12,]
R939 T1311 T1300 appos ],factor
R940 T1312 T1296 punct .,is
R941 T1313 T1320 advmod However,is
R942 T1314 T1320 punct ",",is
R943 T1315 T1320 prep unlike,is
R944 T1316 T1317 amod resting,T-cells
R945 T1317 T1315 pobj T-cells,unlike
R946 T1318 T1320 punct ",",is
R947 T1319 T1320 nsubj NF-κB,is
R948 T1320 T1320 ROOT is,is
R949 T1321 T1322 advmod constitutively,present
R950 T1322 T1320 acomp present,is
R951 T1323 T1322 prep in,present
R952 T1324 T1325 det the,nuclei
R953 T1325 T1323 pobj nuclei,in
R954 T1326 T1325 prep of,nuclei
R955 T1327 T1328 amod primary,monocytes
R956 T1328 T1326 pobj monocytes,of
R957 T1329 T1328 cc and,monocytes
R958 T1330 T1332 amod monocytic,lines
R959 T1331 T1332 compound cell,lines
R960 T1332 T1328 conj lines,monocytes
R961 T1333 T1322 prep in,present
R962 T1334 T1335 det the,absence
R963 T1335 T1333 pobj absence,in
R964 T1336 T1335 prep of,absence
R965 T1337 T1338 amod exogenous,stimuli
R966 T1338 T1336 pobj stimuli,of
R967 T1339 T1340 mark as,demonstrated
R968 T1340 T1322 advcl demonstrated,present
R969 T1341 T1340 agent by,demonstrated
R970 T1342 T1343 compound mobility,shift
R971 T1343 T1344 compound shift,analysis
R972 T1344 T1345 compound analysis,[
R973 T1345 T1347 nmod [,]
R974 T1346 T1347 nummod 13,]
R975 T1347 T1341 pobj ],by
R976 T1348 T1320 punct .,is
R977 T1349 T1355 advmod Similarly,observed
R978 T1350 T1355 punct ",",observed
R979 T1351 T1352 advmod constitutively,active
R980 T1352 T1353 amod active,NF-κB
R981 T1353 T1355 nsubjpass NF-κB,observed
R982 T1354 T1355 auxpass was,observed
R983 T1355 T1355 ROOT observed,observed
R984 T1356 T1355 prep in,observed
R985 T1357 T1359 amod human,macrophages
R986 T1358 T1359 amod alveolar,macrophages
R987 T1359 T1356 pobj macrophages,in
R988 T1360 T1362 nmod [,]
R989 T1361 T1362 nummod 14,]
R990 T1362 T1355 dobj ],observed
R991 T1363 T1355 punct .,observed
R992 T1364 T1374 prep In,sequestered
R993 T1365 T1367 det the,pathway
R994 T1366 T1367 amod classic/canonical,pathway
R995 T1367 T1364 pobj pathway,In
R996 T1368 T1374 punct ",",sequestered
R997 T1369 T1374 det the,sequestered
R998 T1370 T1374 nsubjpass NF-κB,sequestered
R999 T1371 T1372 nummod p50/p65,complex
R1000 T1372 T1374 nsubjpass complex,sequestered
R1001 T1373 T1374 auxpass is,sequestered
R1002 T1374 T1374 ROOT sequestered,sequestered
R1003 T1375 T1374 prep in,sequestered
R1004 T1376 T1377 det the,cytosol
R1005 T1377 T1375 pobj cytosol,in
R1006 T1378 T1374 agent by,sequestered
R1007 T1379 T1380 compound IκBα,[
R1008 T1380 T1378 pobj [,by
R1009 T1381 T1382 nummod 15,]
R1010 T1382 T1380 appos ],[
R1011 T1383 T1374 punct .,sequestered
R1012 T1384 T1394 mark Upon,phosphorylated
R1013 T1385 T1384 pobj stimulation,Upon
R1014 T1386 T1385 prep by,stimulation
R1015 T1387 T1386 pobj cytokines,by
R1016 T1388 T1387 cc or,cytokines
R1017 T1389 T1390 compound UV,radiation
R1018 T1390 T1387 conj radiation,cytokines
R1019 T1391 T1390 punct ",",radiation
R1020 T1392 T1393 nsubj IκBα,is
R1021 T1393 T1394 auxpass is,phosphorylated
R1022 T1394 T1394 ROOT phosphorylated,phosphorylated
R1023 T1395 T1394 punct ",",phosphorylated
R1024 T1396 T1394 conj ubiquitinated,phosphorylated
R1025 T1397 T1396 punct ",",ubiquitinated
R1026 T1398 T1396 cc and,ubiquitinated
R1027 T1399 T1396 conj degraded,ubiquitinated
R1028 T1400 T1394 punct ",",phosphorylated
R1029 T1401 T1394 advcl releasing,phosphorylated
R1030 T1402 T1403 compound NF-κB,p50/p65
R1031 T1403 T1401 dobj p50/p65,releasing
R1032 T1404 T1405 aux to,translocate
R1033 T1405 T1401 advcl translocate,releasing
R1034 T1406 T1405 prep to,translocate
R1035 T1407 T1408 det the,nucleus
R1036 T1408 T1406 pobj nucleus,to
R1037 T1409 T1408 cc and,nucleus
R1038 T1410 T1412 compound transactivate,genes
R1039 T1411 T1412 compound target,genes
R1040 T1412 T1408 conj genes,nucleus
R1041 T1413 T1394 punct .,phosphorylated
R1042 T1414 T1423 prep After,undergo
R1043 T1415 T1416 poss its,release
R1044 T1416 T1414 pobj release,After
R1045 T1417 T1416 prep from,release
R1046 T1418 T1417 pobj IκBα,from
R1047 T1419 T1418 punct ",",IκBα
R1048 T1420 T1421 compound NF-κB,p65
R1049 T1421 T1423 nsubj p65,undergo
R1050 T1422 T1423 aux can,undergo
R1051 T1423 T1423 ROOT undergo,undergo
R1052 T1424 T1425 amod post-translational,modification
R1053 T1425 T1423 dobj modification,undergo
R1054 T1426 T1427 aux to,activate
R1055 T1427 T1423 xcomp activate,undergo
R1056 T1428 T1429 compound gene,transcription
R1057 T1429 T1427 dobj transcription,activate
R1058 T1430 T1423 punct .,undergo
R1059 T1431 T1432 det The,role
R1060 T1432 T1441 nsubj role,varies
R1061 T1433 T1432 prep of,role
R1062 T1434 T1433 pobj NF-κB,of
R1063 T1435 T1436 nummod p65,phosphorylation
R1064 T1436 T1441 nsubj phosphorylation,varies
R1065 T1437 T1436 prep on,phosphorylation
R1066 T1438 T1440 amod NF-κB,activity
R1067 T1439 T1440 amod transcriptional,activity
R1068 T1440 T1437 pobj activity,on
R1069 T1441 T1441 ROOT varies,varies
R1070 T1442 T1441 prep by,varies
R1071 T1443 T1442 pobj stimulus,by
R1072 T1444 T1453 punct ",",]
R1073 T1445 T1453 npadvmod time,]
R1074 T1446 T1445 prep of,time
R1075 T1447 T1446 pobj stimulation,of
R1076 T1448 T1447 cc and,stimulation
R1077 T1449 T1450 compound cell,type
R1078 T1450 T1447 conj type,stimulation
R1079 T1451 T1453 nmod [,]
R1080 T1452 T1453 nummod 16,]
R1081 T1453 T1441 npadvmod ],varies
R1082 T1454 T1441 punct .,varies
R1083 T1455 T1456 amod Previous,research
R1084 T1456 T1457 nsubj research,shows
R1085 T1457 T1457 ROOT shows,shows
R1086 T1458 T1469 mark that,plays
R1087 T1459 T1469 nsubj phosphorylation,plays
R1088 T1460 T1459 prep of,phosphorylation
R1089 T1461 T1462 compound NF-κB,p65
R1090 T1462 T1460 pobj p65,of
R1091 T1463 T1459 prep at,phosphorylation
R1092 T1464 T1463 pobj Ser276,at
R1093 T1465 T1464 punct ",",Ser276
R1094 T1466 T1464 conj Ser529,Ser276
R1095 T1467 T1466 cc or,Ser529
R1096 T1468 T1466 conj Ser536,Ser529
R1097 T1469 T1457 ccomp plays,shows
R1098 T1470 T1472 det an,role
R1099 T1471 T1472 amod important,role
R1100 T1472 T1469 dobj role,plays
R1101 T1473 T1472 prep in,role
R1102 T1474 T1473 pcomp regulating,in
R1103 T1475 T1476 amod transcriptional,activity
R1104 T1476 T1474 dobj activity,regulating
R1105 T1477 T1476 prep of,activity
R1106 T1478 T1479 compound NF-κB,[
R1107 T1479 T1477 pobj [,of
R1108 T1480 T1481 nummod 17,]
R1109 T1481 T1474 dobj ],regulating
R1110 T1482 T1457 punct .,shows
R1111 T1483 T1493 prep In,phosphorylated
R1112 T1484 T1486 amod TNFα-treated,fibroblasts
R1113 T1485 T1486 compound murine,fibroblasts
R1114 T1486 T1483 pobj fibroblasts,In
R1115 T1487 T1493 punct ",",phosphorylated
R1116 T1488 T1493 nsubjpass Ser276,phosphorylated
R1117 T1489 T1488 prep of,Ser276
R1118 T1490 T1489 pobj NF-κB,of
R1119 T1491 T1490 nummod p65,NF-κB
R1120 T1492 T1493 auxpass is,phosphorylated
R1121 T1493 T1493 ROOT phosphorylated,phosphorylated
R1122 T1494 T1493 agent by,phosphorylated
R1123 T1495 T1494 pobj MSK1,by
R1124 T1496 T1497 aux to,enhance
R1125 T1497 T1493 advcl enhance,phosphorylated
R1126 T1498 T1500 amod NF-κB,activity
R1127 T1499 T1500 amod transcriptional,activity
R1128 T1500 T1497 dobj activity,enhance
R1129 T1501 T1503 nmod [,]
R1130 T1502 T1503 nummod 18,]
R1131 T1503 T1500 appos ],activity
R1132 T1504 T1493 punct .,phosphorylated
R1133 T1505 T1515 prep In,associated
R1134 T1506 T1505 pobj macrophages,In
R1135 T1507 T1506 acl treated,macrophages
R1136 T1508 T1507 prep with,treated
R1137 T1509 T1508 pobj endotoxin,with
R1138 T1510 T1515 punct ",",associated
R1139 T1511 T1513 amod NF-κB,activity
R1140 T1512 T1513 compound transcription,activity
R1141 T1513 T1515 nsubjpass activity,associated
R1142 T1514 T1515 auxpass is,associated
R1143 T1515 T1515 ROOT associated,associated
R1144 T1516 T1515 prep with,associated
R1145 T1517 T1516 pobj phosphorylation,with
R1146 T1518 T1517 prep on,phosphorylation
R1147 T1519 T1518 pobj Ser276,on
R1148 T1520 T1519 cc and,Ser276
R1149 T1521 T1519 conj Ser536,Ser276
R1150 T1522 T1524 nsubjpass that,regulated
R1151 T1523 T1524 auxpass is,regulated
R1152 T1524 T1515 conj regulated,associated
R1153 T1525 T1524 prep through,regulated
R1154 T1526 T1525 pobj protein,through
R1155 T1527 T1528 compound kinase,A
R1156 T1528 T1530 det A,PKA
R1157 T1529 T1530 punct (,PKA
R1158 T1530 T1524 oprd PKA,regulated
R1159 T1531 T1530 punct ),PKA
R1160 T1532 T1530 cc and,PKA
R1161 T1533 T1530 conj IKKβ,PKA
R1162 T1534 T1535 compound respectively,[
R1163 T1535 T1530 conj [,PKA
R1164 T1536 T1535 nummod 16,[
R1165 T1537 T1535 conj ],[
R1166 T1538 T1537 punct ",",]
R1167 T1539 T1535 conj [,[
R1168 T1540 T1539 nummod 19,[
R1169 T1541 T1535 conj ],[
R1170 T1542 T1515 punct .,associated
R1171 T1543 T1550 prep In,is
R1172 T1544 T1546 amod human,cells
R1173 T1545 T1546 compound T,cells
R1174 T1546 T1543 pobj cells,In
R1175 T1547 T1550 punct ",",is
R1176 T1548 T1549 compound NF-κB,p65
R1177 T1549 T1550 nsubj p65,is
R1178 T1550 T1550 ROOT is,is
R1179 T1551 T1552 advmod constitutively,phosphorylated
R1180 T1552 T1550 acomp phosphorylated,is
R1181 T1553 T1552 prep on,phosphorylated
R1182 T1554 T1553 pobj Ser536,on
R1183 T1555 T1556 aux to,facilitate
R1184 T1556 T1552 xcomp facilitate,phosphorylated
R1185 T1557 T1560 nmod NF-κB,translocation
R1186 T1558 T1557 nummod p65,NF-κB
R1187 T1559 T1560 amod nuclear,translocation
R1188 T1560 T1556 dobj translocation,facilitate
R1189 T1561 T1560 prep following,translocation
R1190 T1562 T1563 amod cellular,stimulation
R1191 T1563 T1561 pobj stimulation,following
R1192 T1564 T1566 nmod [,]
R1193 T1565 T1566 nummod 20,]
R1194 T1566 T1563 appos ],stimulation
R1195 T1567 T1550 punct .,is
R1196 T1568 T1569 amod Accumulating,evidence
R1197 T1569 T1570 nsubj evidence,reveals
R1198 T1570 T1570 ROOT reveals,reveals
R1199 T1571 T1577 mark that,is
R1200 T1572 T1577 nsubj NF-κB,is
R1201 T1573 T1574 nummod p65,phosphorylation
R1202 T1574 T1577 nsubj phosphorylation,is
R1203 T1575 T1574 prep at,phosphorylation
R1204 T1576 T1575 pobj Ser276,at
R1205 T1577 T1570 ccomp is,reveals
R1206 T1578 T1577 acomp crucial,is
R1207 T1579 T1578 prep for,crucial
R1208 T1580 T1582 poss its,activity
R1209 T1581 T1582 amod transcriptional,activity
R1210 T1582 T1579 pobj activity,for
R1211 T1583 T1570 punct .,reveals
R1212 T1584 T1596 prep Upon,recruits
R1213 T1585 T1586 amod nuclear,translocation
R1214 T1586 T1584 pobj translocation,Upon
R1215 T1587 T1596 punct ",",recruits
R1216 T1588 T1596 nsubj phosphorylation,recruits
R1217 T1589 T1588 prep of,phosphorylation
R1218 T1590 T1589 pobj Ser276,of
R1219 T1591 T1588 prep on,phosphorylation
R1220 T1592 T1591 pobj NF-κB,on
R1221 T1593 T1588 dep p65,phosphorylation
R1222 T1594 T1588 prep by,phosphorylation
R1223 T1595 T1594 pobj PKA,by
R1224 T1596 T1596 ROOT recruits,recruits
R1225 T1597 T1599 det the,co-activator
R1226 T1598 T1599 compound transcription,co-activator
R1227 T1599 T1596 dobj co-activator,recruits
R1228 T1600 T1599 punct ",",co-activator
R1229 T1601 T1599 appos p300,co-activator
R1230 T1602 T1603 aux to,potentiate
R1231 T1603 T1596 advcl potentiate,recruits
R1232 T1604 T1606 amod NF-κB-regulated,transcription
R1233 T1605 T1606 compound gene,transcription
R1234 T1606 T1603 dobj transcription,potentiate
R1235 T1607 T1609 nmod [,]
R1236 T1608 T1609 nummod 21,]
R1237 T1609 T1609 ROOT ],]
R1238 T1610 T1596 punct .,recruits
R1239 T1611 T1615 advmod However,show
R1240 T1612 T1615 punct ",",show
R1241 T1613 T1614 amod other,studies
R1242 T1614 T1615 nsubj studies,show
R1243 T1615 T1615 ROOT show,show
R1244 T1616 T1618 mark that,inhibits
R1245 T1617 T1618 nsubj PKA,inhibits
R1246 T1618 T1615 ccomp inhibits,show
R1247 T1619 T1621 amod NF-κB-regulated,expression
R1248 T1620 T1621 compound gene,expression
R1249 T1621 T1618 dobj expression,inhibits
R1250 T1622 T1618 prep by,inhibits
R1251 T1623 T1622 pcomp stabilizing,by
R1252 T1624 T1625 compound IκBα,[
R1253 T1625 T1623 dobj [,stabilizing
R1254 T1626 T1627 nummod 22,]
R1255 T1627 T1623 dobj ],stabilizing
R1256 T1628 T1629 punct ",",[
R1257 T1629 T1627 npadvmod [,]
R1258 T1630 T1631 nummod 23,]
R1259 T1631 T1627 conj ],]
R1260 T1632 T1615 punct .,show
R1261 T1633 T1640 advmod Interestingly,phosphorylates
R1262 T1634 T1640 punct ",",phosphorylates
R1263 T1635 T1638 det the,Pim-1
R1264 T1636 T1638 amod serine/threonine,Pim-1
R1265 T1637 T1638 compound kinase,Pim-1
R1266 T1638 T1640 nsubj Pim-1,phosphorylates
R1267 T1639 T1640 advmod directly,phosphorylates
R1268 T1640 T1640 ROOT phosphorylates,phosphorylates
R1269 T1641 T1642 compound NF-κB,p65
R1270 T1642 T1640 dobj p65,phosphorylates
R1271 T1643 T1640 prep at,phosphorylates
R1272 T1644 T1643 pobj Ser276,at
R1273 T1645 T1640 prep by,phosphorylates
R1274 T1646 T1645 pcomp stabilizing,by
R1275 T1647 T1648 aux to,prevent
R1276 T1648 T1646 xcomp prevent,stabilizing
R1277 T1649 T1650 amod ubiquitin-proteasome,degradation
R1278 T1650 T1648 dobj degradation,prevent
R1279 T1651 T1653 nmod [,]
R1280 T1652 T1653 nummod 24,]
R1281 T1653 T1650 appos ],degradation
R1282 T1654 T1640 punct .,phosphorylates
R1283 T1655 T1658 amod Several,sites
R1284 T1656 T1658 amod other,sites
R1285 T1657 T1658 amod phosphorylation,sites
R1286 T1658 T1661 nsubjpass sites,described
R1287 T1659 T1661 auxpass are,described
R1288 T1660 T1661 advmod also,described
R1289 T1661 T1661 ROOT described,described
R1290 T1662 T1663 aux to,enhance
R1291 T1663 T1661 xcomp enhance,described
R1292 T1664 T1666 amod NF-κB,transactivation
R1293 T1665 T1666 compound gene,transactivation
R1294 T1666 T1663 dobj transactivation,enhance
R1295 T1667 T1669 nmod [,]
R1296 T1668 T1669 nummod 25,]
R1297 T1669 T1666 appos ],transactivation
R1298 T1670 T1661 punct .,described
R1299 T1671 T1674 advmod Here,investigate
R1300 T1672 T1674 punct ",",investigate
R1301 T1673 T1674 nsubj we,investigate
R1302 T1674 T1674 ROOT investigate,investigate
R1303 T1675 T1676 det the,role
R1304 T1676 T1674 dobj role,investigate
R1305 T1677 T1676 prep of,role
R1306 T1678 T1677 pobj protein,of
R1307 T1679 T1680 compound kinase,C
R1308 T1680 T1680 ROOT C,C
R1309 T1681 T1680 punct (,C
R1310 T1682 T1680 appos PKC,C
R1311 T1683 T1680 punct ),C
R1312 T1684 T1676 prep in,role
R1313 T1685 T1686 compound M-CSF-stimulated,NF-κB
R1314 T1686 T1687 compound NF-κB,activation
R1315 T1687 T1684 pobj activation,in
R1316 T1688 T1674 punct .,investigate
R1317 T1689 T1690 compound PKC,proteins
R1318 T1690 T1691 nsubj proteins,are
R1319 T1691 T1691 ROOT are,are
R1320 T1692 T1693 amod multifunctional,kinases
R1321 T1693 T1691 attr kinases,are
R1322 T1694 T1695 nsubj that,differ
R1323 T1695 T1693 relcl differ,kinases
R1324 T1696 T1695 prep in,differ
R1325 T1697 T1696 pobj structure,in
R1326 T1698 T1697 punct ",",structure
R1327 T1699 T1695 npadvmod function,differ
R1328 T1700 T1699 cc and,function
R1329 T1701 T1699 conj co-factor,function
R1330 T1702 T1705 compound requirement,]
R1331 T1703 T1705 nmod [,]
R1332 T1704 T1705 nummod 26,]
R1333 T1705 T1693 appos ],kinases
R1334 T1706 T1691 punct .,are
R1335 T1707 T1709 nsubjpass PKCs,involved
R1336 T1708 T1709 auxpass are,involved
R1337 T1709 T1709 ROOT involved,involved
R1338 T1710 T1709 prep in,involved
R1339 T1711 T1713 amod diverse,responses
R1340 T1712 T1713 compound cell,responses
R1341 T1713 T1710 pobj responses,in
R1342 T1714 T1713 punct ",",responses
R1343 T1715 T1713 prep including,responses
R1344 T1716 T1717 compound cell,growth
R1345 T1717 T1715 pobj growth,including
R1346 T1718 T1717 punct ",",growth
R1347 T1719 T1717 conj survival,growth
R1348 T1720 T1719 punct ",",survival
R1349 T1721 T1719 conj differentiation,survival
R1350 T1722 T1721 cc and,differentiation
R1351 T1723 T1721 conj development,differentiation
R1352 T1724 T1726 nmod [,]
R1353 T1725 T1726 nummod 27,]
R1354 T1726 T1717 appos ],growth
R1355 T1727 T1709 punct .,involved
R1356 T1728 T1732 det The,enzymes
R1357 T1729 T1732 nummod 12,enzymes
R1358 T1730 T1731 advmod closely,related
R1359 T1731 T1732 amod related,enzymes
R1360 T1732 T1738 nsubjpass enzymes,divided
R1361 T1733 T1732 prep of,enzymes
R1362 T1734 T1736 det the,family
R1363 T1735 T1736 compound PKC,family
R1364 T1736 T1733 pobj family,of
R1365 T1737 T1738 auxpass are,divided
R1366 T1738 T1738 ROOT divided,divided
R1367 T1739 T1738 prep into,divided
R1368 T1740 T1741 nummod three,classes
R1369 T1741 T1739 pobj classes,into
R1370 T1742 T1741 punct :,classes
R1371 T1743 T1741 appos conventional,classes
R1372 T1744 T1747 punct (,α
R1373 T1745 T1747 dep cPKCs,α
R1374 T1746 T1747 punct :,α
R1375 T1747 T1752 nsubj α,require
R1376 T1748 T1749 compound βI,βII
R1377 T1749 T1752 nsubj βII,require
R1378 T1750 T1749 cc and,βII
R1379 T1751 T1749 conj γ,βII
R1380 T1752 T1738 advcl require,divided
R1381 T1753 T1754 amod Ca2,+
R1382 T1754 T1752 dobj +,require
R1383 T1755 T1754 cc and,+
R1384 T1756 T1754 conj diacylglycerol,+
R1385 T1757 T1758 punct (,DAG
R1386 T1758 T1756 appos DAG,diacylglycerol
R1387 T1759 T1756 punct ),diacylglycerol
R1388 T1760 T1752 punct ;,require
R1389 T1761 T1752 conj novel,require
R1390 T1762 T1765 punct (,δ
R1391 T1763 T1765 dep nPKCs,δ
R1392 T1764 T1765 punct :,δ
R1393 T1765 T1761 appos δ,novel
R1394 T1766 T1765 punct ",",δ
R1395 T1767 T1765 dep ε,δ
R1396 T1768 T1767 punct ",",ε
R1397 T1769 T1765 dep η,δ
R1398 T1770 T1769 punct ",",η
R1399 T1771 T1769 dep θ,η
R1400 T1772 T1771 cc and,θ
R1401 T1773 T1771 conj μ,θ
R1402 T1774 T1773 punct ),μ
R1403 T1775 T1765 dep require,δ
R1404 T1776 T1775 dobj DAG,require
R1405 T1777 T1765 punct ;,δ
R1406 T1778 T1765 cc and,δ
R1407 T1843 T1844 compound TNFα,mRNA
R1408 T1779 T1765 conj atypical,δ
R1409 T1780 T1789 punct (,require
R1410 T1844 T1841 conj mRNA,iNOS
R1411 T1781 T1789 nsubj aPKCs,require
R1412 T1845 T1838 dobj production,induces
R1413 T1846 T1838 prep after,induces
R1414 T1847 T1854 nmod lipopolysaccharide,]
R1415 T1782 T1783 punct :,ξ
R1416 T1848 T1849 punct (,LPS
R1417 T1849 T1847 appos LPS,lipopolysaccharide
R1418 T1850 T1849 punct ),LPS
R1419 T1851 T1847 conj exposure,lipopolysaccharide
R1420 T1852 T1854 nmod [,]
R1421 T1783 T1789 nsubj ξ,require
R1422 T1784 T1783 punct ",",ξ
R1423 T1853 T1854 nummod 29,]
R1424 T1785 T1783 dep ι,ξ
R1425 T1854 T1846 pobj ],after
R1426 T1855 T1838 punct .,induces
R1427 T1856 T1861 prep In,suggests
R1428 T1786 T1785 cc and,ι
R1429 T1857 T1856 pobj addition,In
R1430 T1858 T1861 punct ",",suggests
R1431 T1787 T1785 conj λ,ι
R1432 T1859 T1860 amod accumulating,evidence
R1433 T1860 T1861 nsubj evidence,suggests
R1434 T1861 T1861 ROOT suggests,suggests
R1435 T1788 T1787 punct ),λ
R1436 T1862 T1867 mark that,have
R1437 T1863 T1864 amod conventional,PKCs
R1438 T1864 T1867 nsubj PKCs,have
R1439 T1789 T1779 parataxis require,atypical
R1440 T1865 T1864 prep like,PKCs
R1441 T1866 T1865 pobj PKCα,like
R1442 T1867 T1861 ccomp have,suggests
R1443 T1790 T1791 preconj neither,Ca2
R1444 T1868 T1869 amod anti-apoptotic,functions
R1445 T1869 T1867 dobj functions,have
R1446 T1870 T1861 punct .,suggests
R1447 T1791 T1792 intj Ca2,+
R1448 T1871 T1876 prep For,overexpressed
R1449 T1792 T1789 dobj +,require
R1450 T1872 T1871 pobj example,For
R1451 T1873 T1876 punct ",",overexpressed
R1452 T1874 T1875 nsubj PKCα,is
R1453 T1875 T1876 auxpass is,overexpressed
R1454 T1876 T1876 ROOT overexpressed,overexpressed
R1455 T1877 T1876 prep in,overexpressed
R1456 T1793 T1792 cc nor,+
R1457 T1878 T1879 det a,variety
R1458 T1879 T1877 pobj variety,in
R1459 T1880 T1879 prep of,variety
R1460 T1881 T1882 compound tumor,cells
R1461 T1794 T1792 conj DAG,+
R1462 T1882 T1880 pobj cells,of
R1463 T1883 T1882 prep including,cells
R1464 T1795 T1789 punct .,require
R1465 T1884 T1883 pobj gliomas,including
R1466 T1885 T1884 punct ",",gliomas
R1467 T1886 T1884 conj liver,gliomas
R1468 T1887 T1886 punct ",",liver
R1469 T1888 T1886 cc and,liver
R1470 T1889 T1886 conj lung,liver
R1471 T1890 T1892 nmod [,]
R1472 T1796 T1800 nsubj Monocytes,express
R1473 T1891 T1892 nummod 30,]
R1474 T1892 T1883 pobj ],including
R1475 T1893 T1892 punct ",",]
R1476 T1797 T1796 cc and,Monocytes
R1477 T1894 T1896 nmod [,]
R1478 T1895 T1896 nummod 31,]
R1479 T1896 T1892 conj ],]
R1480 T1798 T1796 conj macrophages,Monocytes
R1481 T1897 T1876 punct .,overexpressed
R1482 T1898 T1905 prep In,induces
R1483 T1799 T1800 advmod predominantly,express
R1484 T1899 T1900 amod epithelial,cells
R1485 T1900 T1898 pobj cells,In
R1486 T1901 T1905 punct ",",induces
R1487 T1800 T1800 ROOT express,express
R1488 T1902 T1905 nsubj inhibition,induces
R1489 T1903 T1902 prep of,inhibition
R1490 T1801 T1803 amod conventional,isoforms
R1491 T1904 T1903 pobj PKCα,of
R1492 T1905 T1905 ROOT induces,induces
R1493 T1906 T1907 amod PKCδ-dependent,apoptosis
R1494 T1802 T1803 compound PKC,isoforms
R1495 T1803 T1800 dobj isoforms,express
R1496 T1907 T1908 compound apoptosis,[
R1497 T1804 T1803 punct (,isoforms
R1498 T1908 T1905 dobj [,induces
R1499 T1909 T1910 nummod 31,]
R1500 T1805 T1806 compound PKCα,PKCβI
R1501 T1910 T1908 appos ],[
R1502 T1911 T1905 punct .,induces
R1503 T1912 T1927 advmod Interestingly,have
R1504 T1913 T1927 punct ",",have
R1505 T1806 T1803 appos PKCβI,isoforms
R1506 T1914 T1927 prep in,have
R1507 T1915 T1916 amod human,monocytes
R1508 T1807 T1806 cc and,PKCβI
R1509 T1916 T1914 pobj monocytes,in
R1510 T1917 T1916 cc and,monocytes
R1511 T1808 T1806 conj PKCβII,PKCβI
R1512 T1918 T1921 amod premonocytic,cells
R1513 T1919 T1921 compound THP-1,cells
R1514 T1920 T1921 compound leukemia,cells
R1515 T1809 T1806 punct ),PKCβI
R1516 T1921 T1916 conj cells,monocytes
R1517 T1922 T1921 punct ",",cells
R1518 T1923 T1924 compound novel,PKCs
R1519 T1924 T1921 conj PKCs,cells
R1520 T1925 T1924 prep like,PKCs
R1521 T1926 T1925 pobj PKCδ,like
R1522 T1810 T1806 cc and,PKCβI
R1523 T1927 T1938 ccomp have,showed
R1524 T1928 T1930 det the,effect
R1525 T1929 T1930 amod opposite,effect
R1526 T1930 T1927 dobj effect,have
R1527 T1811 T1812 amod novel,PKCs
R1528 T1931 T1930 prep on,effect
R1529 T1932 T1933 compound cell,survival
R1530 T1933 T1931 pobj survival,on
R1531 T1812 T1806 conj PKCs,PKCβI
R1532 T1934 T1938 punct ",",showed
R1533 T1935 T1937 compound Voss,al
R1534 T1813 T1812 punct (,PKCs
R1535 T1936 T1937 compound et,al
R1536 T1937 T1938 nsubj al,showed
R1537 T1938 T1938 ROOT showed,showed
R1538 T1939 T1942 mark that,phosphorylates
R1539 T1814 T1812 conj PKCδ,PKCs
R1540 T1940 T1942 nsubj PKCδ,phosphorylates
R1541 T1815 T1814 cc and,PKCδ
R1542 T1816 T1814 conj PKCε,PKCδ
R1543 T1817 T1812 punct ),PKCs
R1544 T1818 T1800 punct .,express
R1545 T1941 T1942 advmod directly,phosphorylates
R1546 T1942 T1938 ccomp phosphorylates,showed
R1547 T1943 T1942 dobj caspase-3,phosphorylates
R1548 T1819 T1820 amod Conventional,PKCs
R1549 T1944 T1942 cc and,phosphorylates
R1550 T1945 T1942 conj promotes,phosphorylates
R1551 T1820 T1821 nsubj PKCs,regulate
R1552 T1946 T1947 amod etoposide-induced,apoptosis
R1553 T1947 T1948 compound apoptosis,[
R1554 T1948 T1945 dobj [,promotes
R1555 T1821 T1821 ROOT regulate,regulate
R1556 T1949 T1950 nummod 32,]
R1557 T1950 T1948 appos ],[
R1558 T1822 T1821 dobj differentiation,regulate
R1559 T1951 T1938 punct .,showed
R1560 T1952 T1957 advmod Moreover,suggest
R1561 T1823 T1822 prep of,differentiation
R1562 T1953 T1957 punct ",",suggest
R1563 T1954 T1956 compound knockout,studies
R1564 T1955 T1956 compound mouse,studies
R1565 T1824 T1829 det the,line
R1566 T1956 T1957 nsubj studies,suggest
R1567 T1957 T1966 advcl suggest,involved
R1568 T1825 T1828 amod human,cell
R1569 T1958 T1960 mark that,novel
R1570 T1959 T1960 det another,novel
R1571 T1960 T1957 ccomp novel,suggest
R1572 T1961 T1960 appos PKC,novel
R1573 T1962 T1966 punct ",",involved
R1574 T1963 T1966 nsubjpass PKCε,involved
R1575 T1964 T1966 auxpass is,involved
R1576 T1826 T1828 amod promyelocytic,cell
R1577 T1965 T1966 advmod critically,involved
R1578 T1966 T1966 ROOT involved,involved
R1579 T1967 T1966 prep in,involved
R1580 T1827 T1828 compound leukemia,cell
R1581 T1968 T1970 amod early,signaling
R1582 T1969 T1970 amod LPS-mediated,signaling
R1583 T1970 T1967 pobj signaling,in
R1584 T1828 T1829 compound cell,line
R1585 T1971 T1970 prep in,signaling
R1586 T1972 T1973 amod activated,macrophages
R1587 T1973 T1971 pobj macrophages,in
R1588 T1829 T1823 pobj line,of
R1589 T1974 T1976 nmod [,]
R1590 T1975 T1976 nummod 33,]
R1591 T1976 T1970 appos ],signaling
R1592 T1830 T1835 nummod HL60,]
R1593 T1977 T1966 punct .,involved
R1594 T1978 T1981 advmod Previously,reported
R1595 T1979 T1981 punct ",",reported
R1596 T1980 T1981 nsubj we,reported
R1597 T1831 T1835 prep to,]
R1598 T1981 T1981 ROOT reported,reported
R1599 T1982 T1984 mark that,promotes
R1600 T1832 T1831 pobj macrophages,to
R1601 T1983 T1984 nsubj M-CSF,promotes
R1602 T1984 T1981 ccomp promotes,reported
R1603 T1833 T1835 nmod [,]
R1604 T1985 T1986 compound monocyte,survival
R1605 T1834 T1835 nummod 28,]
R1606 T1986 T1984 dobj survival,promotes
R1607 T1835 T1829 appos ],line
R1608 T1987 T1984 prep through,promotes
R1609 T1988 T1989 det the,activation
R1610 T1989 T1987 pobj activation,through
R1611 T1836 T1821 punct .,regulate
R1612 T1990 T1989 prep of,activation
R1613 T1991 T1993 det the,pathway
R1614 T1992 T1993 compound PI3-K/AKT,pathway
R1615 T1837 T1838 nsubj PKCα,induces
R1616 T1993 T1990 pobj pathway,of
R1617 T1994 T1989 appos [,activation
R1618 T1838 T1838 ROOT induces,induces
R1619 T1995 T1996 nummod 3,]
R1620 T1996 T1994 appos ],[
R1621 T1997 T1981 punct .,reported
R1622 T1998 T2005 prep In,stimulates
R1623 T1999 T1998 pobj addition,In
R1624 T2000 T1999 prep to,addition
R1625 T1839 T1838 dobj IL-1α,induces
R1626 T2001 T2002 compound AKT,activation
R1627 T2002 T2000 pobj activation,to
R1628 T2003 T2005 punct ",",stimulates
R1629 T1840 T1839 punct ",",IL-1α
R1630 T2004 T2005 nsubj M-CSF,stimulates
R1631 T2005 T2005 ROOT stimulates,stimulates
R1632 T2006 T2005 dobj PKC,stimulates
R1633 T2007 T2005 prep in,stimulates
R1634 T1841 T1839 conj iNOS,IL-1α
R1635 T2008 T2009 amod human,monocytes
R1636 T2009 T2007 pobj monocytes,in
R1637 T2010 T2009 cc and,monocytes
R1638 T1842 T1841 cc and,iNOS
R1639 T2011 T2009 conj increases,monocytes
R1640 T2012 T2013 compound NF-κB,DNA
R1641 T2013 T2017 det DNA,]
R1642 T2038 T2043 prep In,plays
R1643 T2014 T2017 amod binding,]
R1644 T2015 T2017 nmod [,]
R1645 T2016 T2017 nummod 34,]
R1646 T2017 T2005 dobj ],stimulates
R1647 T2039 T2040 amod other,cells
R1648 T2018 T2005 punct .,stimulates
R1649 T2019 T2035 advmod However,is
R1650 T2020 T2035 punct ",",is
R1651 T2021 T2026 mark whether,is
R1652 T2040 T2038 pobj cells,In
R1653 T2022 T2025 poss PKC,activation
R1654 T2023 T2022 cc and/or,PKC
R1655 T2024 T2022 conj NF-κB,PKC
R1656 T2041 T2043 punct ",",plays
R1657 T2025 T2026 nsubj activation,is
R1658 T2026 T2035 csubj is,is
R1659 T2027 T2026 acomp critical,is
R1660 T2028 T2027 prep in,critical
R1661 T2042 T2043 nsubj PKC,plays
R1662 T2029 T2032 amod M-CSF-stimulated,survival
R1663 T2030 T2032 nmod mononuclear,survival
R1664 T2031 T2032 compound phagocyte,survival
R1665 T2043 T2043 ROOT plays,plays
R1666 T2032 T2028 pobj survival,in
R1667 T2033 T2032 cc and/or,survival
R1668 T2034 T2032 conj differentiation,survival
R1669 T2044 T2046 det an,role
R1670 T2035 T2035 ROOT is,is
R1671 T2036 T2035 acomp unclear,is
R1672 T2037 T2035 punct .,is
R1673 T2045 T2046 amod important,role
R1674 T2046 T2043 dobj role,plays
R1675 T2047 T2046 prep in,role
R1676 T2135 T2132 conj siRNA,constructs
R1677 T2048 T2049 amod NF-κB,activation
R1678 T2136 T2117 punct .,reduced
R1679 T2137 T2137 ROOT Conventional,Conventional
R1680 T2138 T2139 nsubj PKC,regulated
R1681 T2139 T2139 ROOT regulated,regulated
R1682 T2049 T2047 pobj activation,in
R1683 T2140 T2142 amod NF-κB-regulated,expression
R1684 T2141 T2142 compound gene,expression
R1685 T2050 T2049 cc and,activation
R1686 T2142 T2139 dobj expression,regulated
R1687 T2143 T2142 cc and,expression
R1688 T2051 T2052 compound cell,survival
R1689 T2052 T2049 conj survival,activation
R1690 T2144 T2142 conj phosphorylation,expression
R1691 T2145 T2142 prep of,expression
R1692 T2053 T2055 nmod [,]
R1693 T2146 T2145 pobj Ser276,of
R1694 T2147 T2146 prep of,Ser276
R1695 T2148 T2147 pobj NF-κB,of
R1696 T2054 T2055 nummod 35,]
R1697 T2149 T2148 nummod p65,NF-κB
R1698 T2150 T2139 conj occurred,regulated
R1699 T2055 T2073 nsubjpass ],known
R1700 T2151 T2150 prep in,occurred
R1701 T2152 T2154 det an,fashion
R1702 T2153 T2154 amod M-CSF-dependent,fashion
R1703 T2056 T2060 punct ",",mechanisms
R1704 T2154 T2151 pobj fashion,in
R1705 T2155 T2154 acl correlating,fashion
R1706 T2156 T2155 prep with,correlating
R1707 T2057 T2060 advmod however,mechanisms
R1708 T2157 T2160 poss its,activity
R1709 T2158 T2160 amod maximal,activity
R1710 T2058 T2060 det the,mechanisms
R1711 T2159 T2160 amod transcriptional,activity
R1712 T2160 T2156 pobj activity,with
R1713 T2161 T2139 punct .,regulated
R1714 T2059 T2060 amod specific,mechanisms
R1715 T2162 T2171 advmod Furthermore,plays
R1716 T2163 T2171 punct ",",plays
R1717 T2164 T2165 amod PKCα-regulated,phosphorylation
R1718 T2060 T2073 nsubjpass mechanisms,known
R1719 T2165 T2171 nsubj phosphorylation,plays
R1720 T2166 T2165 prep of,phosphorylation
R1721 T2167 T2166 pobj Ser276,of
R1722 T2168 T2167 prep of,Ser276
R1723 T2169 T2168 pobj NF-κB,of
R1724 T2170 T2169 nummod p65,NF-κB
R1725 T2171 T2171 ROOT plays,plays
R1726 T2061 T2060 prep of,mechanisms
R1727 T2172 T2174 det an,role
R1728 T2173 T2174 amod important,role
R1729 T2174 T2171 dobj role,plays
R1730 T2175 T2174 prep in,role
R1731 T2062 T2063 det this,activation
R1732 T2176 T2175 pcomp regulating,in
R1733 T2177 T2178 poss its,activity
R1734 T2178 T2176 dobj activity,regulating
R1735 T2063 T2061 pobj activation,of
R1736 T2179 T2176 prep in,regulating
R1737 T2180 T2181 compound mononuclear,phagocytes
R1738 T2181 T2179 pobj phagocytes,in
R1739 T2064 T2063 cc and,activation
R1740 T2182 T2181 cc and,phagocytes
R1741 T2183 T2185 amod murine,fibroblasts
R1742 T2184 T2185 amod embryonic,fibroblasts
R1743 T2065 T2067 det the,effects
R1744 T2185 T2181 conj fibroblasts,phagocytes
R1745 T2186 T2171 punct .,plays
R1746 T2066 T2067 amod biological,effects
R1747 T2067 T2063 conj effects,activation
R1748 T2068 T2067 prep on,effects
R1749 T2069 T2070 amod cellular,phenotype
R1750 T2070 T2068 pobj phenotype,on
R1751 T2071 T2073 auxpass are,known
R1752 T2072 T2073 neg not,known
R1753 T2073 T2073 ROOT known,known
R1760 T2074 T2073 punct .,known
R1761 T2075 T2078 advmod Therefore,focused
R1767 T2076 T2078 punct ",",focused
R1770 T2077 T2078 nsubj we,focused
R1776 T2078 T2078 ROOT focused,focused
R1780 T2079 T2078 prep at,focused
R1782 T2080 T2079 pcomp understanding,at
R1791 T2081 T2082 det the,role
R1794 T2082 T2080 dobj role,understanding
R1795 T2083 T2082 prep of,role
R1798 T2084 T2083 pobj PKC,of
R1804 T2085 T2082 prep in,role
R1806 T2086 T2087 det the,regulation
R1810 T2087 T2085 pobj regulation,in
R1815 T2088 T2087 prep of,regulation
R1817 T2089 T2090 amod NF-κB,activation
R1818 T2090 T2088 pobj activation,of
R1824 T2091 T2090 cc and,activation
R1826 T2092 T2094 amod M-CSF-induced,survival
R1827 T2093 T2094 compound monocyte,survival
R1836 T2094 T2090 conj survival,activation
R1840 T2095 T2078 punct .,focused
R1845 T2096 T2098 advmod Here,demonstrates
R1848 T2097 T2098 nsubj we,demonstrates
R1853 T2098 T2098 ROOT demonstrates,demonstrates
R1859 T2099 T2101 mark that,upregulated
R1861 T2100 T2101 nsubj M-CSF,upregulated
R1864 T2101 T2098 ccomp upregulated,demonstrates
R1865 T2102 T2104 det the,transcription
R1868 T2103 T2104 compound NF-κB,transcription
R1871 T2104 T2101 dobj transcription,upregulated
R1879 T2105 T2104 cc and,transcription
R1885 T2106 T2107 compound cell,survival
R1889 T2107 T2104 conj survival,transcription
R1893 T2108 T2104 prep in,transcription
R1894 T2109 T2112 amod human,macrophages
R1898 T2110 T2109 cc and,human
R1905 T2111 T2109 conj mouse,human
R1911 T2112 T2108 pobj macrophages,in
R1913 T2113 T2098 punct .,demonstrates
R1916 T2114 T2115 det This,activity
R1919 T2115 T2117 nsubjpass activity,reduced
R1926 T2116 T2117 auxpass was,reduced
R1930 T2117 T2117 ROOT reduced,reduced
R1933 T2118 T2117 agent by,reduced
R1936 T2119 T2120 det the,conventional
R1940 T2120 T2118 pobj conventional,by
R1944 T2121 T2117 punct ",",reduced
R1948 T2122 T2117 cc but,reduced
R1951 T2123 T2124 neg not,novel
R1954 T2124 T2117 conj novel,reduced
R1955 T2125 T2124 punct ",",novel
R1956 T2126 T2127 compound PKC,inhibitors
R1957 T2127 T2124 appos inhibitors,novel
R1960 T2128 T2127 punct ",",inhibitors
R1963 T2129 T2132 amod dominant,constructs
R1964 T2130 T2132 amod negative,constructs
R1966 T2131 T2132 compound PKCα,constructs
R1977 T2132 T2127 conj constructs,inhibitors
R1978 T2133 T2132 cc or,constructs
R1984 T2134 T2135 compound PKCα,siRNA
R10607 T14524 T14523 prep in,important

test2

Id Subject Object Predicate Lexical cue
T907 162-198 Protein denotes Macrophage colony-stimulating factor
T908 200-205 Protein denotes M-CSF
T909 287-292 Protein denotes M-CSF
T910 543-548 Protein denotes M-CSF
T911 866-870 Protein denotes RelA
T912 871-874 Protein denotes p65
T913 876-879 Protein denotes p50
T914 881-884 Protein denotes p52
T915 886-891 Protein denotes c-Rel
T916 896-900 Protein denotes RelB
T917 944-947 Protein denotes p50
T918 948-951 Protein denotes p65
T919 1010-1013 Protein denotes p65
T920 1029-1032 Protein denotes p65
T921 1093-1100 Negative_regulation denotes lacking
T922 1107-1110 Protein denotes p65
T923 1217-1220 Protein denotes p65
T924 1221-1225 Negative_regulation denotes null
T925 1250-1254 Protein denotes TNFα
T926 1293-1307 Gene_expression denotes overexpressing
T927 1318-1321 Protein denotes p65
T928 1984-1987 Protein denotes p50
T929 1988-1991 Protein denotes p65
T930 2033-2037 Protein denotes IκBα
T931 2091-2095 Protein denotes IκBα
T932 2099-2113 Phosphorylation denotes phosphorylated
T933 2134-2142 Protein_catabolism denotes degraded
T934 2144-2153 Negative_regulation denotes releasing
T935 2160-2163 Protein denotes p50
T936 2164-2167 Protein denotes p65
T937 2171-2182 Localization denotes translocate
T938 2190-2197 Entity denotes nucleus
T939 2240-2247 Localization denotes release
T940 2253-2257 Protein denotes IκBα
T941 2265-2268 Protein denotes p65
T942 2281-2312 Protein_modification denotes post-translational modification
T943 2349-2353 Regulation denotes role
T944 2363-2366 Protein denotes p65
T945 2367-2382 Phosphorylation denotes phosphorylation
T946 2506-2521 Phosphorylation denotes phosphorylation
T947 2531-2534 Protein denotes p65
T948 2538-2544 Entity denotes Ser276
T949 2546-2552 Entity denotes Ser529
T950 2556-2562 Entity denotes Ser536
T951 2677-2683 Entity denotes Ser276
T952 2693-2696 Protein denotes p65
T953 2700-2714 Phosphorylation denotes phosphorylated
T954 2718-2722 Protein denotes MSK1
T955 2858-2873 Phosphorylation denotes phosphorylation
T956 2877-2883 Entity denotes Ser276
T957 2888-2894 Entity denotes Ser536
T958 2903-2912 Regulation denotes regulated
T959 2948-2952 Protein denotes IKKβ
R616 T908 T907 equivalentTo M-CSF,Macrophage colony-stimulating factor
R617 T912 T911 equivalentTo p65,RelA
R618 T922 T921 themeOf p65,lacking
R619 T923 T924 themeOf p65,null
R620 T927 T926 themeOf p65,overexpressing
R621 T931 T933 themeOf IκBα,degraded
R622 T931 T932 themeOf IκBα,phosphorylated
R623 T935 T937 themeOf p50,translocate
R624 T936 T937 themeOf p65,translocate
R625 T937 T934 themeOf translocate,releasing
R626 T938 T937 locationOf nucleus,translocate
R627 T940 T939 themeOf IκBα,release
R628 T940 T942 themeOf IκBα,post-translational modification
R629 T941 T939 themeOf p65,release
R630 T941 T942 themeOf p65,post-translational modification
R631 T944 T945 themeOf p65,phosphorylation
R632 T945 T943 themeOf phosphorylation,role
R633 T948 T946 themeOf Ser276,phosphorylation
R634 T948 T947 partOf Ser276,p65
R635 T949 T947 partOf Ser529,p65
R636 T949 T946 themeOf Ser529,phosphorylation
R637 T950 T946 themeOf Ser536,phosphorylation
R638 T950 T947 partOf Ser536,p65
R639 T951 T953 themeOf Ser276,phosphorylated
R640 T951 T952 partOf Ser276,p65
R641 T954 T953 causeOf MSK1,phosphorylated
R642 T955 T958 themeOf phosphorylation,regulated
R643 T956 T955 themeOf Ser276,phosphorylation
R644 T957 T955 themeOf Ser536,phosphorylation
R645 T959 T958 causeOf IKKβ,regulated