PMC:3245220 / 1347-8076
Annnotations
bionlp-st-ge-2016-uniprot
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T3308 | 162-198 | P09603 | denotes | Macrophage colony-stimulating factor |
T3309 | 173-198 | P04141 | denotes | colony-stimulating factor |
T3310 | 200-205 | P09603 | denotes | M-CSF |
T3311 | 202-205 | P04141 | denotes | CSF |
T3312 | 287-292 | P09603 | denotes | M-CSF |
T3313 | 289-292 | P04141 | denotes | CSF |
T3314 | 543-548 | P09603 | denotes | M-CSF |
T3315 | 545-548 | P04141 | denotes | CSF |
T3316 | 866-870 | Q04206-3 | denotes | RelA |
T3317 | 866-870 | Q04206 | denotes | RelA |
T3318 | 871-874 | P21579 | denotes | p65 |
T3319 | 871-874 | Q04206 | denotes | p65 |
T3320 | 876-879 | P19838 | denotes | p50 |
T3321 | 881-884 | Q00653 | denotes | p52 |
T3322 | 886-891 | Q04864 | denotes | c-Rel |
T3323 | 888-891 | Q04864 | denotes | Rel |
T3324 | 896-900 | Q01201 | denotes | RelB |
T3325 | 944-947 | P19838 | denotes | p50 |
T3326 | 948-951 | Q04206 | denotes | p65 |
T3327 | 948-951 | P21579 | denotes | p65 |
T3328 | 1010-1013 | Q04206 | denotes | p65 |
T3329 | 1010-1013 | P21579 | denotes | p65 |
T3330 | 1029-1032 | Q04206 | denotes | p65 |
T3331 | 1029-1032 | P21579 | denotes | p65 |
T3332 | 1107-1110 | P21579 | denotes | p65 |
T3333 | 1107-1110 | Q04206 | denotes | p65 |
T3334 | 1217-1220 | P21579 | denotes | p65 |
T3335 | 1217-1220 | Q04206 | denotes | p65 |
T3336 | 1318-1321 | Q04206 | denotes | p65 |
T3337 | 1318-1321 | P21579 | denotes | p65 |
T3338 | 1984-1987 | P19838 | denotes | p50 |
T3339 | 1988-1991 | Q04206 | denotes | p65 |
T3340 | 1988-1991 | P21579 | denotes | p65 |
T3341 | 2033-2037 | P25963 | denotes | IκBα |
T3342 | 2091-2095 | P25963 | denotes | IκBα |
T3343 | 2160-2163 | P19838 | denotes | p50 |
T3344 | 2164-2167 | P21579 | denotes | p65 |
T3345 | 2164-2167 | Q04206 | denotes | p65 |
T3346 | 2253-2257 | P25963 | denotes | IκBα |
T3347 | 2265-2268 | Q04206 | denotes | p65 |
T3348 | 2265-2268 | P21579 | denotes | p65 |
T3349 | 2363-2366 | Q04206 | denotes | p65 |
T3350 | 2363-2366 | P21579 | denotes | p65 |
T3351 | 2531-2534 | P21579 | denotes | p65 |
T3352 | 2531-2534 | Q04206 | denotes | p65 |
T3353 | 2693-2696 | Q04206 | denotes | p65 |
T3354 | 2693-2696 | P21579 | denotes | p65 |
T3355 | 2718-2722 | O75582 | denotes | MSK1 |
T3356 | 2948-2952 | O14920 | denotes | IKKβ |
T3357 | 3001-3004 | P21579 | denotes | p65 |
T3358 | 3001-3004 | Q04206 | denotes | p65 |
T3359 | 3068-3071 | Q04206 | denotes | p65 |
T3360 | 3068-3071 | P21579 | denotes | p65 |
T3361 | 3172-3175 | P21579 | denotes | p65 |
T3362 | 3172-3175 | Q04206 | denotes | p65 |
T3363 | 3310-3313 | Q04206 | denotes | p65 |
T3364 | 3310-3313 | P21579 | denotes | p65 |
T3365 | 3362-3366 | Q09472 | denotes | p300 |
T3366 | 3515-3519 | P25963 | denotes | IκBα |
T3367 | 3611-3614 | P21579 | denotes | p65 |
T3368 | 3611-3614 | Q04206 | denotes | p65 |
T3369 | 3848-3853 | P09603 | denotes | M-CSF |
T3370 | 3850-3853 | P04141 | denotes | CSF |
T3371 | 4446-4450 | P17252 | denotes | PKCα |
T3372 | 4461-4467 | P05771 | denotes | PKCβII |
T3373 | 4485-4489 | Q05655 | denotes | PKCδ |
T3374 | 4616-4620 | P17252 | denotes | PKCα |
T3375 | 4784-4788 | P17252 | denotes | PKCα |
T3376 | 4833-4837 | P17252 | denotes | PKCα |
T3377 | 4965-4969 | P17252 | denotes | PKCα |
T3378 | 4978-4982 | Q05655 | denotes | PKCδ |
T3379 | 5098-5102 | Q05655 | denotes | PKCδ |
T3380 | 5169-5173 | Q05655 | denotes | PKCδ |
T3381 | 5198-5207 | P42574 | denotes | caspase-3 |
T3382 | 5440-5445 | P09603 | denotes | M-CSF |
T3383 | 5442-5445 | P04141 | denotes | CSF |
T3384 | 5509-5512 | P31751 | denotes | AKT |
T3385 | 5509-5512 | P31749 | denotes | AKT |
T3386 | 5509-5512 | Q9Y243 | denotes | AKT |
T3387 | 5541-5544 | P31751 | denotes | AKT |
T3388 | 5541-5544 | Q9Y243 | denotes | AKT |
T3389 | 5541-5544 | P31749 | denotes | AKT |
T3390 | 5557-5562 | P09603 | denotes | M-CSF |
T3391 | 5559-5562 | P04141 | denotes | CSF |
T3392 | 5695-5700 | P09603 | denotes | M-CSF |
T3393 | 5697-5700 | P04141 | denotes | CSF |
T3394 | 6078-6083 | P09603 | denotes | M-CSF |
T3395 | 6080-6083 | P04141 | denotes | CSF |
T3396 | 6137-6142 | P09603 | denotes | M-CSF |
T3397 | 6139-6142 | P04141 | denotes | CSF |
T3398 | 6325-6329 | P17252 | denotes | PKCα |
T3399 | 6344-6348 | P17252 | denotes | PKCα |
T3400 | 6454-6457 | P21579 | denotes | p65 |
T3401 | 6454-6457 | Q04206 | denotes | p65 |
T3402 | 6473-6478 | P09603 | denotes | M-CSF |
T3403 | 6475-6478 | P04141 | denotes | CSF |
T3404 | 6565-6569 | P17252 | denotes | PKCα |
T3405 | 6615-6618 | P21579 | denotes | p65 |
T3406 | 6615-6618 | Q04206 | denotes | p65 |
bionlp-st-ge-2016-reference
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T3407 | 1093-1100 | Negative_regulation | denotes | lacking |
T3408 | 2367-2382 | Phosphorylation | denotes | phosphorylation |
T3409 | 2506-2521 | Phosphorylation | denotes | phosphorylation |
T3410 | 2506-2521 | Phosphorylation | denotes | phosphorylation |
T3411 | 2506-2521 | Phosphorylation | denotes | phosphorylation |
T3412 | 2700-2714 | Phosphorylation | denotes | phosphorylated |
T3413 | 2858-2873 | Phosphorylation | denotes | phosphorylation |
T3414 | 2858-2873 | Phosphorylation | denotes | phosphorylation |
T3415 | 2903-2912 | Regulation | denotes | regulated |
T3416 | 2903-2912 | Regulation | denotes | regulated |
T3417 | 3023-3037 | Phosphorylation | denotes | phosphorylated |
T3418 | 1221-1225 | Negative_regulation | denotes | null |
T3419 | 3080-3093 | Localization | denotes | translocation |
T3420 | 3176-3191 | Phosphorylation | denotes | phosphorylation |
T3421 | 3275-3290 | Phosphorylation | denotes | phosphorylation |
T3422 | 3314-3316 | Positive_regulation | denotes | by |
T3423 | 3503-3514 | Positive_regulation | denotes | stabilizing |
T3424 | 3590-3604 | Phosphorylation | denotes | phosphorylates |
T3425 | 4621-4628 | Positive_regulation | denotes | induces |
T3426 | 4655-4665 | Transcription | denotes | production |
T3427 | 4621-4628 | Positive_regulation | denotes | induces |
T3428 | 4655-4665 | Transcription | denotes | production |
T3429 | 1293-1307 | Gene_expression | denotes | overexpressing |
T3430 | 4621-4628 | Positive_regulation | denotes | induces |
T3431 | 4655-4665 | Transcription | denotes | production |
T3432 | 4841-4854 | Positive_regulation | denotes | overexpressed |
T3433 | 4951-4961 | Negative_regulation | denotes | inhibition |
T3434 | 5183-5197 | Phosphorylation | denotes | phosphorylates |
T3435 | 6373-6382 | Regulation | denotes | regulated |
T3436 | 6419-6434 | Phosphorylation | denotes | phosphorylation |
T3437 | 6479-6488 | Regulation | denotes | dependent |
T3438 | 6570-6579 | Regulation | denotes | regulated |
T3439 | 6580-6595 | Phosphorylation | denotes | phosphorylation |
T3440 | 2044-2048 | Positive_regulation | denotes | Upon |
T3441 | 2099-2113 | Phosphorylation | denotes | phosphorylated |
T3442 | 2044-2048 | Positive_regulation | denotes | Upon |
T3443 | 2134-2142 | Protein_catabolism | denotes | degraded |
T3444 | 2240-2247 | Localization | denotes | release |
T3445 | 2281-2312 | Protein_modification | denotes | post-translational modification |
T3446 | 866-870 | Protein | denotes | RelA |
T3447 | 1029-1032 | Protein | denotes | p65 |
T3448 | 6454-6457 | Protein | denotes | p65 |
T3449 | 6615-6618 | Protein | denotes | p65 |
T3450 | 6438-6444 | Entity | denotes | Ser276 |
T3451 | 1107-1110 | Protein | denotes | p65 |
T3452 | 6599-6605 | Entity | denotes | Ser276 |
T3453 | 1217-1220 | Protein | denotes | p65 |
T3454 | 1250-1254 | Protein | denotes | TNFα |
T3455 | 1318-1321 | Protein | denotes | p65 |
T3456 | 1984-1987 | Protein | denotes | p50 |
T3457 | 1988-1991 | Protein | denotes | p65 |
T3458 | 2033-2037 | Protein | denotes | IκBα |
T3459 | 2091-2095 | Protein | denotes | IκBα |
T3460 | 2160-2163 | Protein | denotes | p50 |
T3461 | 871-874 | Protein | denotes | p65 |
T3462 | 2164-2167 | Protein | denotes | p65 |
T3463 | 2253-2257 | Protein | denotes | IκBα |
T3464 | 2265-2268 | Protein | denotes | p65 |
T3465 | 2363-2366 | Protein | denotes | p65 |
T3466 | 2531-2534 | Protein | denotes | p65 |
T3467 | 2693-2696 | Protein | denotes | p65 |
T3468 | 2718-2722 | Protein | denotes | MSK1 |
T3469 | 2948-2952 | Protein | denotes | IKKβ |
T3470 | 3001-3004 | Protein | denotes | p65 |
T3471 | 3068-3071 | Protein | denotes | p65 |
T3472 | 876-879 | Protein | denotes | p50 |
T3473 | 3172-3175 | Protein | denotes | p65 |
T3474 | 3310-3313 | Protein | denotes | p65 |
T3475 | 3362-3366 | Protein | denotes | p300 |
T3476 | 3515-3519 | Protein | denotes | IκBα |
T3477 | 3575-3580 | Protein | denotes | Pim-1 |
T3478 | 3611-3614 | Protein | denotes | p65 |
T3479 | 881-884 | Protein | denotes | p52 |
T3480 | 2538-2544 | Entity | denotes | Ser276 |
T3481 | 2546-2552 | Entity | denotes | Ser529 |
T3482 | 886-891 | Protein | denotes | c-Rel |
T3483 | 2556-2562 | Entity | denotes | Ser536 |
T3484 | 2677-2683 | Entity | denotes | Ser276 |
T3485 | 2877-2883 | Entity | denotes | Ser276 |
T3486 | 2888-2894 | Entity | denotes | Ser536 |
T3487 | 3041-3047 | Entity | denotes | Ser536 |
T3488 | 3072-3079 | Entity | denotes | nuclear |
T3489 | 896-900 | Protein | denotes | RelB |
T3490 | 3195-3201 | Entity | denotes | Ser276 |
T3491 | 3294-3300 | Entity | denotes | Ser276 |
T3492 | 3618-3624 | Entity | denotes | Ser276 |
T3493 | 4209-4210 | Protein | denotes | α |
T3494 | 944-947 | Protein | denotes | p50 |
T3495 | 4214-4217 | Protein | denotes | βII |
T3496 | 4222-4223 | Protein | denotes | γ |
T3497 | 4277-4278 | Protein | denotes | δ |
T3498 | 4280-4281 | Protein | denotes | ε |
T3499 | 4283-4284 | Protein | denotes | η |
T3500 | 4286-4287 | Protein | denotes | θ |
T3501 | 4292-4293 | Protein | denotes | μ |
T3502 | 4329-4330 | Protein | denotes | ξ |
T3503 | 4332-4333 | Protein | denotes | ι |
T3504 | 948-951 | Protein | denotes | p65 |
T3505 | 4338-4339 | Protein | denotes | λ |
T3506 | 4446-4450 | Protein | denotes | PKCα |
T3507 | 4451-4456 | Protein | denotes | PKCβI |
T3508 | 4461-4467 | Protein | denotes | PKCβII |
T3509 | 4485-4489 | Protein | denotes | PKCδ |
T3510 | 4494-4498 | Protein | denotes | PKCε |
T3511 | 4616-4620 | Protein | denotes | PKCα |
T3512 | 4629-4634 | Protein | denotes | IL-1α |
T3513 | 4636-4640 | Protein | denotes | iNOS |
T3514 | 4645-4649 | Protein | denotes | TNFα |
T3515 | 1010-1013 | Protein | denotes | p65 |
T3516 | 4784-4788 | Protein | denotes | PKCα |
T3517 | 4833-4837 | Protein | denotes | PKCα |
T3518 | 4965-4969 | Protein | denotes | PKCα |
T3519 | 4978-4982 | Protein | denotes | PKCδ |
T3520 | 5098-5102 | Protein | denotes | PKCδ |
T3521 | 5169-5173 | Protein | denotes | PKCδ |
T3522 | 5198-5207 | Protein | denotes | caspase-3 |
T3523 | 5320-5324 | Protein | denotes | PKCε |
T3524 | 6307-6329 | Protein | denotes | dominant negative PKCα |
T3525 | 6344-6354 | Protein | denotes | PKCα siRNA |
T3526 | 162-198 | Protein | denotes | Macrophage colony-stimulating factor |
T3527 | 200-205 | Protein | denotes | M-CSF |
T3528 | 543-548 | Protein | denotes | M-CSF |
T3529 | 287-292 | Protein | denotes | M-CSF |
T3530 | 3848-3853 | Protein | denotes | M-CSF |
T3531 | 5440-5445 | Protein | denotes | M-CSF |
T3532 | 5557-5562 | Protein | denotes | M-CSF |
T3533 | 5695-5700 | Protein | denotes | M-CSF |
T3534 | 6078-6083 | Protein | denotes | M-CSF |
T3535 | 6137-6142 | Protein | denotes | M-CSF |
T3536 | 6473-6478 | Protein | denotes | M-CSF |
T3537 | 4211-4213 | Protein | denotes | βI |
R2924 | T3413 | T3415 | themeOf | phosphorylation,regulated |
R2925 | T3414 | T3416 | themeOf | phosphorylation,regulated |
R2926 | T3421 | T3422 | themeOf | phosphorylation,by |
R2927 | T3431 | T3430 | themeOf | production,induces |
R2928 | T3435 | T3437 | themeOf | regulated,dependent |
R2929 | T3436 | T3435 | themeOf | phosphorylation,regulated |
R2930 | T3426 | T3425 | themeOf | production,induces |
R2931 | T3439 | T3438 | themeOf | phosphorylation,regulated |
R2932 | T3441 | T3440 | themeOf | phosphorylated,Upon |
R2933 | T3443 | T3442 | themeOf | degraded,Upon |
R2934 | T3428 | T3427 | themeOf | production,induces |
R2935 | T3446 | T3461 | equivalentTo | RelA,p65 |
R2936 | T3483 | T3411 | themeOf | Ser536,phosphorylation |
R2937 | T3450 | T3436 | themeOf | Ser276,phosphorylation |
R2938 | T3450 | T3448 | partOf | Ser276,p65 |
R2939 | T3483 | T3466 | partOf | Ser536,p65 |
R2940 | T3451 | T3407 | themeOf | p65,lacking |
R2941 | T3452 | T3439 | themeOf | Ser276,phosphorylation |
R2942 | T3452 | T3449 | partOf | Ser276,p65 |
R2943 | T3484 | T3412 | themeOf | Ser276,phosphorylated |
R2944 | T3453 | T3418 | themeOf | p65,null |
R2945 | T3455 | T3429 | themeOf | p65,overexpressing |
R2946 | T3484 | T3467 | partOf | Ser276,p65 |
R2947 | T3485 | T3413 | themeOf | Ser276,phosphorylation |
R2948 | T3485 | T3467 | partOf | Ser276,p65 |
R2949 | T3459 | T3443 | themeOf | IκBα,degraded |
R2950 | T3459 | T3441 | themeOf | IκBα,phosphorylated |
R2951 | T3486 | T3414 | themeOf | Ser536,phosphorylation |
R2952 | T3486 | T3467 | partOf | Ser536,p65 |
R2953 | T3487 | T3417 | themeOf | Ser536,phosphorylated |
R2954 | T3464 | T3444 | themeOf | p65,release |
R2955 | T3464 | T3445 | themeOf | p65,post-translational modification |
R2956 | T3465 | T3408 | themeOf | p65,phosphorylation |
R2957 | T3487 | T3470 | partOf | Ser536,p65 |
R2958 | T3488 | T3419 | locationOf | nuclear,translocation |
R2959 | T3468 | T3412 | causeOf | MSK1,phosphorylated |
R2960 | T3469 | T3415 | causeOf | IKKβ,regulated |
R2961 | T3469 | T3416 | causeOf | IKKβ,regulated |
R2962 | T3471 | T3419 | themeOf | p65,translocation |
R2963 | T3490 | T3420 | themeOf | Ser276,phosphorylation |
R2964 | T3490 | T3473 | partOf | Ser276,p65 |
R2965 | T3491 | T3421 | themeOf | Ser276,phosphorylation |
R2966 | T3476 | T3423 | themeOf | IκBα,stabilizing |
R2967 | T3477 | T3424 | causeOf | Pim-1,phosphorylates |
R2968 | T3491 | T3474 | partOf | Ser276,p65 |
R2969 | T3492 | T3424 | themeOf | Ser276,phosphorylates |
R2970 | T3480 | T3409 | themeOf | Ser276,phosphorylation |
R2971 | T3480 | T3466 | partOf | Ser276,p65 |
R2972 | T3481 | T3410 | themeOf | Ser529,phosphorylation |
R2973 | T3481 | T3466 | partOf | Ser529,p65 |
R2974 | T3492 | T3478 | partOf | Ser276,p65 |
R2975 | T3511 | T3425 | causeOf | PKCα,induces |
R2976 | T3511 | T3427 | causeOf | PKCα,induces |
R2977 | T3511 | T3430 | causeOf | PKCα,induces |
R2978 | T3512 | T3426 | themeOf | IL-1α,production |
R2979 | T3513 | T3428 | themeOf | iNOS,production |
R2980 | T3514 | T3431 | themeOf | TNFα,production |
R2981 | T3517 | T3432 | themeOf | PKCα,overexpressed |
R2982 | T3518 | T3433 | themeOf | PKCα,inhibition |
R2983 | T3521 | T3434 | causeOf | PKCδ,phosphorylates |
R2984 | T3522 | T3434 | themeOf | caspase-3,phosphorylates |
R2985 | T3527 | T3526 | equivalentTo | M-CSF,Macrophage colony-stimulating factor |
R2986 | T3536 | T3437 | causeOf | M-CSF,dependent |
bionlp-st-ge-2016-reference-tees
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T4393 | 162-198 | Protein | denotes | Macrophage colony-stimulating factor |
T4394 | 200-205 | Protein | denotes | M-CSF |
T4395 | 287-292 | Protein | denotes | M-CSF |
T4396 | 510-515 | Protein | denotes | NF-κB |
T4397 | 543-548 | Protein | denotes | M-CSF |
T4398 | 516-526 | Positive_regulation | denotes | activation |
T4399 | 664-669 | Protein | denotes | NF-κB |
T4400 | 852-864 | Protein | denotes | NF-κB family |
T4401 | 866-870 | Protein | denotes | RelA |
T4402 | 871-874 | Protein | denotes | p65 |
T4403 | 876-879 | Protein | denotes | p50 |
T4404 | 881-884 | Protein | denotes | p52 |
T4405 | 886-891 | Protein | denotes | c-Rel |
T4406 | 896-900 | Protein | denotes | RelB |
T4407 | 944-947 | Protein | denotes | p50 |
T4408 | 948-951 | Protein | denotes | p65 |
T4409 | 1004-1009 | Protein | denotes | NF-κB |
T4410 | 1010-1021 | Protein | denotes | p65 subunit |
T4411 | 990-996 | Entity | denotes | domain |
T4412 | 1023-1028 | Protein | denotes | NF-κB |
T4413 | 1029-1032 | Protein | denotes | p65 |
T4414 | 1101-1110 | Protein | denotes | NF-κB p65 |
T4415 | 1093-1100 | Negative_regulation | denotes | lacking |
T4416 | 1211-1216 | Protein | denotes | NF-κB |
T4417 | 1217-1220 | Protein | denotes | p65 |
T4418 | 1250-1254 | Protein | denotes | TNFα |
T4419 | 1312-1329 | Protein | denotes | NF-κB p65 subunit |
T4420 | 1293-1307 | Gene_expression | denotes | overexpressing |
T4421 | 1357-1362 | Protein | denotes | NF-κB |
T4422 | 1472-1477 | Protein | denotes | NF-κB |
T4423 | 1536-1541 | Protein | denotes | NF-κB |
T4424 | 1585-1595 | Gene_expression | denotes | expression |
T4425 | 1675-1680 | Protein | denotes | NF-κB |
T4426 | 1885-1890 | Protein | denotes | NF-κB |
T4427 | 1978-1983 | Protein | denotes | NF-κB |
T4428 | 1984-1987 | Protein | denotes | p50 |
T4429 | 1988-1991 | Protein | denotes | p65 |
T4430 | 2033-2042 | Protein | denotes | IκBα [15] |
T4431 | 2091-2095 | Protein | denotes | IκBα |
T4432 | 2154-2159 | Protein | denotes | NF-κB |
T4433 | 2160-2163 | Protein | denotes | p50 |
T4434 | 2164-2167 | Protein | denotes | p65 |
T4435 | 2099-2113 | Phosphorylation | denotes | phosphorylated |
T4436 | 2134-2142 | Protein_catabolism | denotes | degraded |
T4437 | 2144-2153 | Localization | denotes | releasing |
T4438 | 2144-2153 | Localization | denotes | releasing |
T4439 | 2144-2153 | Localization | denotes | releasing |
T4440 | 2190-2197 | Entity | denotes | nucleus |
T4441 | 2171-2182 | Localization | denotes | translocate |
T4442 | 2171-2182 | Localization | denotes | translocate |
T4443 | 2171-2182 | Localization | denotes | translocate |
T4444 | 2253-2257 | Protein | denotes | IκBα |
T4445 | 2259-2264 | Protein | denotes | NF-κB |
T4446 | 2265-2268 | Protein | denotes | p65 |
T4447 | 2357-2362 | Protein | denotes | NF-κB |
T4448 | 2363-2366 | Protein | denotes | p65 |
T4449 | 2386-2391 | Protein | denotes | NF-κB |
T4450 | 2367-2382 | Phosphorylation | denotes | phosphorylation |
T4451 | 2367-2382 | Phosphorylation | denotes | phosphorylation |
T4452 | 2349-2353 | Regulation | denotes | role |
T4453 | 2349-2353 | Regulation | denotes | role |
T4454 | 2525-2534 | Protein | denotes | NF-κB p65 |
T4455 | 2629-2634 | Protein | denotes | NF-κB |
T4456 | 2506-2521 | Phosphorylation | denotes | phosphorylation |
T4457 | 2644-2648 | Protein | denotes | TNFα |
T4458 | 2687-2696 | Protein | denotes | NF-κB p65 |
T4459 | 2718-2722 | Protein | denotes | MSK1 |
T4460 | 2734-2739 | Protein | denotes | NF-κB |
T4461 | 2700-2714 | Phosphorylation | denotes | phosphorylated |
T4462 | 2726-2733 | Positive_regulation | denotes | enhance |
T4463 | 2810-2815 | Protein | denotes | NF-κB |
T4464 | 2921-2937 | Protein | denotes | protein kinase A |
T4465 | 2939-2942 | Protein | denotes | PKA |
T4466 | 2948-2952 | Protein | denotes | IKKβ |
T4467 | 2842-2852 | Binding | denotes | associated |
T4468 | 2995-3004 | Protein | denotes | NF-κB p65 |
T4469 | 3062-3067 | Protein | denotes | NF-κB |
T4470 | 3068-3071 | Protein | denotes | p65 |
T4471 | 3041-3047 | Entity | denotes | Ser536 |
T4472 | 3072-3079 | Entity | denotes | nuclear |
T4473 | 3080-3093 | Localization | denotes | translocation |
T4474 | 3080-3093 | Localization | denotes | translocation |
T4475 | 3023-3037 | Phosphorylation | denotes | phosphorylated |
T4476 | 3051-3061 | Positive_regulation | denotes | facilitate |
T4477 | 3051-3061 | Positive_regulation | denotes | facilitate |
T4478 | 3166-3171 | Protein | denotes | NF-κB |
T4479 | 3172-3175 | Protein | denotes | p65 |
T4480 | 3176-3191 | Phosphorylation | denotes | phosphorylation |
T4481 | 3176-3191 | Phosphorylation | denotes | phosphorylation |
T4482 | 3205-3212 | Positive_regulation | denotes | crucial |
T4483 | 3205-3212 | Positive_regulation | denotes | crucial |
T4484 | 3304-3309 | Protein | denotes | NF-κB |
T4485 | 3310-3313 | Protein | denotes | p65 |
T4486 | 3317-3320 | Protein | denotes | PKA |
T4487 | 3362-3366 | Protein | denotes | p300 |
T4488 | 3381-3386 | Protein | denotes | NF-κB |
T4489 | 3252-3259 | Entity | denotes | nuclear |
T4490 | 3294-3300 | Entity | denotes | Ser276 |
T4491 | 3275-3290 | Phosphorylation | denotes | phosphorylation |
T4492 | 3275-3290 | Phosphorylation | denotes | phosphorylation |
T4493 | 3275-3290 | Phosphorylation | denotes | phosphorylation |
T4494 | 3455-3458 | Protein | denotes | PKA |
T4495 | 3468-3473 | Protein | denotes | NF-κB |
T4496 | 3551-3574 | Protein | denotes | serine/threonine kinase |
T4497 | 3575-3580 | Protein | denotes | Pim-1 |
T4498 | 3605-3614 | Protein | denotes | NF-κB p65 |
T4499 | 3651-3660 | Protein | denotes | ubiquitin |
T4500 | 3672-3683 | Protein_catabolism | denotes | degradation |
T4501 | 3756-3761 | Protein | denotes | NF-κB |
T4502 | 3748-3755 | Positive_regulation | denotes | enhance |
T4503 | 3822-3838 | Protein | denotes | protein kinase C |
T4504 | 3840-3843 | Protein | denotes | PKC |
T4505 | 3848-3853 | Protein | denotes | M-CSF |
T4506 | 3865-3870 | Protein | denotes | NF-κB |
T4507 | 3883-3895 | Protein | denotes | PKC proteins |
T4508 | 3991-3995 | Protein | denotes | PKCs |
T4509 | 4145-4155 | Protein | denotes | PKC family |
T4510 | 4209-4217 | Protein | denotes | α βI βII |
T4511 | 4461-4467 | Protein | denotes | PKCβII |
T4512 | 4411-4418 | Gene_expression | denotes | express |
T4513 | 4616-4620 | Protein | denotes | PKCα |
T4514 | 4629-4634 | Protein | denotes | IL-1α |
T4515 | 4636-4640 | Protein | denotes | iNOS |
T4516 | 4645-4654 | Protein | denotes | TNFα mRNA |
T4517 | 4655-4665 | Gene_expression | denotes | production |
T4518 | 4655-4665 | Gene_expression | denotes | production |
T4519 | 4655-4665 | Gene_expression | denotes | production |
T4520 | 4621-4628 | Positive_regulation | denotes | induces |
T4521 | 4621-4628 | Positive_regulation | denotes | induces |
T4522 | 4621-4628 | Positive_regulation | denotes | induces |
T4523 | 4774-4788 | Protein | denotes | PKCs like PKCα |
T4524 | 4833-4837 | Protein | denotes | PKCα |
T4525 | 4841-4854 | Gene_expression | denotes | overexpressed |
T4526 | 4841-4854 | Positive_regulation | denotes | overexpressed |
T4527 | 4965-4982 | Protein | denotes | PKCα induces PKCδ |
T4528 | 5088-5102 | Protein | denotes | PKCs like PKCδ |
T4529 | 5169-5173 | Protein | denotes | PKCδ |
T4530 | 5198-5207 | Protein | denotes | caspase-3 |
T4531 | 5183-5197 | Phosphorylation | denotes | phosphorylates |
T4532 | 5183-5197 | Phosphorylation | denotes | phosphorylates |
T4533 | 5315-5318 | Protein | denotes | PKC |
T4534 | 5320-5324 | Protein | denotes | PKCε |
T4535 | 5440-5445 | Protein | denotes | M-CSF |
T4536 | 5503-5508 | Protein | denotes | PI3-K |
T4537 | 5509-5512 | Protein | denotes | AKT |
T4538 | 5485-5495 | Positive_regulation | denotes | activation |
T4539 | 5485-5495 | Positive_regulation | denotes | activation |
T4540 | 5541-5544 | Protein | denotes | AKT |
T4541 | 5557-5562 | Protein | denotes | M-CSF |
T4542 | 5574-5577 | Protein | denotes | PKC |
T4543 | 5611-5616 | Protein | denotes | NF-κB |
T4544 | 5545-5555 | Positive_regulation | denotes | activation |
T4545 | 5563-5573 | Positive_regulation | denotes | stimulates |
T4546 | 5563-5573 | Positive_regulation | denotes | stimulates |
T4547 | 5621-5628 | Binding | denotes | binding |
T4548 | 5601-5610 | Positive_regulation | denotes | increases |
T4549 | 5652-5655 | Protein | denotes | PKC |
T4550 | 5663-5668 | Protein | denotes | NF-κB |
T4551 | 5695-5700 | Protein | denotes | M-CSF |
T4552 | 5669-5679 | Positive_regulation | denotes | activation |
T4553 | 5669-5679 | Positive_regulation | denotes | activation |
T4554 | 5794-5797 | Protein | denotes | PKC |
T4555 | 5825-5830 | Protein | denotes | NF-κB |
T4556 | 6032-6035 | Protein | denotes | PKC |
T4557 | 6057-6062 | Protein | denotes | NF-κB |
T4558 | 6078-6083 | Protein | denotes | M-CSF |
T4559 | 6063-6073 | Positive_regulation | denotes | activation |
T4560 | 6043-6053 | Regulation | denotes | regulation |
T4561 | 6024-6028 | Regulation | denotes | role |
T4562 | 6137-6142 | Protein | denotes | M-CSF |
T4563 | 6159-6164 | Protein | denotes | NF-κB |
T4564 | 6165-6178 | Transcription | denotes | transcription |
T4565 | 6143-6154 | Positive_regulation | denotes | upregulated |
T4566 | 6291-6294 | Protein | denotes | PKC |
T4567 | 6325-6329 | Protein | denotes | PKCα |
T4568 | 6344-6354 | Protein | denotes | PKCα siRNA |
T4569 | 6369-6372 | Protein | denotes | PKC |
T4570 | 6383-6388 | Protein | denotes | NF-κB |
T4571 | 6448-6457 | Protein | denotes | NF-κB p65 |
T4572 | 6473-6478 | Protein | denotes | M-CSF |
T4573 | 6419-6434 | Phosphorylation | denotes | phosphorylation |
T4574 | 6438-6444 | Positive_regulation | denotes | Ser276 |
T4575 | 6438-6444 | Positive_regulation | denotes | Ser276 |
T4576 | 6458-6466 | Positive_regulation | denotes | occurred |
T4577 | 6565-6569 | Protein | denotes | PKCα |
T4578 | 6609-6614 | Protein | denotes | NF-κB |
T4579 | 6615-6618 | Protein | denotes | p65 |
T4580 | 6599-6605 | Entity | denotes | Ser276 |
T4581 | 6580-6595 | Phosphorylation | denotes | phosphorylation |
T4582 | 6580-6595 | Phosphorylation | denotes | phosphorylation |
T4583 | 6570-6579 | Regulation | denotes | regulated |
T4584 | 6570-6579 | Regulation | denotes | regulated |
R3328 | T4460 | T4462 | themeOf | NF-κB,enhance |
R3329 | T4463 | T4467 | themeOf | NF-κB,associated |
R3330 | T4396 | T4398 | themeOf | NF-κB,activation |
R3331 | T4468 | T4475 | themeOf | NF-κB p65,phosphorylated |
R3332 | T4468 | T4476 | causeOf | NF-κB p65,facilitate |
R3333 | T4468 | T4477 | causeOf | NF-κB p65,facilitate |
R3334 | T4469 | T4473 | themeOf | NF-κB,translocation |
R3335 | T4409 | T4411 | partOf | NF-κB,domain |
R3336 | T4410 | T4411 | partOf | p65 subunit,domain |
R3337 | T4470 | T4474 | themeOf | p65,translocation |
R3338 | T4471 | T4475 | Site | Ser536,phosphorylated |
R3339 | T4414 | T4415 | themeOf | NF-κB p65,lacking |
R3340 | T4472 | T4473 | locationOf | nuclear,translocation |
R3341 | T4472 | T4474 | locationOf | nuclear,translocation |
R3342 | T4419 | T4420 | themeOf | NF-κB p65 subunit,overexpressing |
R3343 | T4473 | T4476 | themeOf | translocation,facilitate |
R3344 | T4423 | T4424 | themeOf | NF-κB,expression |
R3345 | T4474 | T4477 | themeOf | translocation,facilitate |
R3346 | T4478 | T4480 | themeOf | NF-κB,phosphorylation |
R3347 | T4431 | T4435 | themeOf | IκBα,phosphorylated |
R3348 | T4431 | T4436 | themeOf | IκBα,degraded |
R3349 | T4432 | T4437 | themeOf | NF-κB,releasing |
R3350 | T4432 | T4441 | themeOf | NF-κB,translocate |
R3351 | T4433 | T4438 | themeOf | p50,releasing |
R3352 | T4433 | T4442 | themeOf | p50,translocate |
R3353 | T4479 | T4481 | themeOf | p65,phosphorylation |
R3354 | T4434 | T4439 | themeOf | p65,releasing |
R3355 | T4434 | T4443 | themeOf | p65,translocate |
R3356 | T4480 | T4482 | themeOf | phosphorylation,crucial |
R3357 | T4481 | T4483 | themeOf | phosphorylation,crucial |
R3358 | T4440 | T4441 | locationOf | nucleus,translocate |
R3359 | T4440 | T4442 | locationOf | nucleus,translocate |
R3360 | T4440 | T4443 | locationOf | nucleus,translocate |
R3361 | T4484 | T4491 | themeOf | NF-κB,phosphorylation |
R3362 | T4485 | T4492 | themeOf | p65,phosphorylation |
R3363 | T4447 | T4450 | themeOf | NF-κB,phosphorylation |
R3364 | T4448 | T4451 | themeOf | p65,phosphorylation |
R3365 | T4485 | T4490 | partOf | p65,Ser276 |
R3366 | T4450 | T4452 | themeOf | phosphorylation,role |
R3367 | T4486 | T4493 | themeOf | PKA,phosphorylation |
R3368 | T4451 | T4453 | themeOf | phosphorylation,role |
R3369 | T4486 | T4490 | partOf | PKA,Ser276 |
R3370 | T4454 | T4456 | themeOf | NF-κB p65,phosphorylation |
R3371 | T4490 | T4491 | Site | Ser276,phosphorylation |
R3372 | T4458 | T4461 | themeOf | NF-κB p65,phosphorylated |
R3373 | T4490 | T4492 | Site | Ser276,phosphorylation |
R3374 | T4490 | T4493 | Site | Ser276,phosphorylation |
R3375 | T4499 | T4500 | themeOf | ubiquitin,degradation |
R3376 | T4529 | T4531 | themeOf | PKCδ,phosphorylates |
R3377 | T4530 | T4532 | themeOf | caspase-3,phosphorylates |
R3378 | T4501 | T4502 | themeOf | NF-κB,enhance |
R3379 | T4535 | T4538 | causeOf | M-CSF,activation |
R3380 | T4535 | T4539 | causeOf | M-CSF,activation |
R3381 | T4536 | T4538 | themeOf | PI3-K,activation |
R3382 | T4537 | T4539 | themeOf | AKT,activation |
R3383 | T4511 | T4512 | themeOf | PKCβII,express |
R3384 | T4540 | T4544 | themeOf | AKT,activation |
R3385 | T4541 | T4545 | causeOf | M-CSF,stimulates |
R3386 | T4541 | T4546 | causeOf | M-CSF,stimulates |
R3387 | T4541 | T4548 | causeOf | M-CSF,increases |
R3388 | T4542 | T4545 | themeOf | PKC,stimulates |
R3389 | T4543 | T4547 | themeOf | NF-κB,binding |
R3390 | T4544 | T4546 | themeOf | activation,stimulates |
R3391 | T4547 | T4548 | themeOf | binding,increases |
R3392 | T4549 | T4552 | themeOf | PKC,activation |
R3393 | T4550 | T4553 | themeOf | NF-κB,activation |
R3394 | T4513 | T4520 | causeOf | PKCα,induces |
R3395 | T4556 | T4561 | causeOf | PKC,role |
R3396 | T4557 | T4559 | themeOf | NF-κB,activation |
R3397 | T4559 | T4560 | themeOf | activation,regulation |
R3398 | T4513 | T4521 | causeOf | PKCα,induces |
R3399 | T4560 | T4561 | themeOf | regulation,role |
R3400 | T4513 | T4522 | causeOf | PKCα,induces |
R3401 | T4514 | T4517 | themeOf | IL-1α,production |
R3402 | T4562 | T4565 | causeOf | M-CSF,upregulated |
R3403 | T4563 | T4564 | themeOf | NF-κB,transcription |
R3404 | T4564 | T4565 | themeOf | transcription,upregulated |
R3405 | T4515 | T4518 | themeOf | iNOS,production |
R3406 | T4516 | T4519 | themeOf | TNFα mRNA,production |
R3407 | T4517 | T4520 | themeOf | production,induces |
R3408 | T4571 | T4573 | themeOf | NF-κB p65,phosphorylation |
R3409 | T4518 | T4521 | themeOf | production,induces |
R3410 | T4571 | T4574 | themeOf | NF-κB p65,Ser276 |
R3411 | T4519 | T4522 | themeOf | production,induces |
R3412 | T4573 | T4575 | themeOf | phosphorylation,Ser276 |
R3413 | T4573 | T4576 | themeOf | phosphorylation,occurred |
R3414 | T4524 | T4525 | themeOf | PKCα,overexpressed |
R3415 | T4577 | T4583 | causeOf | PKCα,regulated |
R3416 | T4577 | T4584 | causeOf | PKCα,regulated |
R3417 | T4578 | T4581 | themeOf | NF-κB,phosphorylation |
R3418 | T4578 | T4580 | partOf | NF-κB,Ser276 |
R3419 | T4579 | T4582 | themeOf | p65,phosphorylation |
R3420 | T4579 | T4580 | partOf | p65,Ser276 |
R3421 | T4580 | T4581 | Site | Ser276,phosphorylation |
R3422 | T4580 | T4582 | Site | Ser276,phosphorylation |
R3423 | T4581 | T4583 | themeOf | phosphorylation,regulated |
R3424 | T4525 | T4526 | themeOf | overexpressed,overexpressed |
R3425 | T4582 | T4584 | themeOf | phosphorylation,regulated |
events-check-again
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T4262 | 162-198 | Protein | denotes | Macrophage colony-stimulating factor |
T4263 | 200-205 | Protein | denotes | M-CSF |
T4264 | 287-292 | Protein | denotes | M-CSF |
T4265 | 543-548 | Protein | denotes | M-CSF |
T4266 | 866-870 | Protein | denotes | RelA |
T4267 | 871-874 | Protein | denotes | p65 |
T4268 | 876-879 | Protein | denotes | p50 |
T4269 | 881-884 | Protein | denotes | p52 |
T4270 | 886-891 | Protein | denotes | c-Rel |
T4271 | 896-900 | Protein | denotes | RelB |
T4272 | 944-947 | Protein | denotes | p50 |
T4273 | 948-951 | Protein | denotes | p65 |
T4274 | 1010-1013 | Protein | denotes | p65 |
T4275 | 1029-1032 | Protein | denotes | p65 |
T4276 | 1093-1100 | Negative_regulation | denotes | lacking |
T4277 | 1107-1110 | Protein | denotes | p65 |
T4278 | 1217-1220 | Protein | denotes | p65 |
T4279 | 1221-1225 | Negative_regulation | denotes | null |
T4280 | 1250-1254 | Protein | denotes | TNFα |
T4281 | 1293-1307 | Gene_expression | denotes | overexpressing |
T4282 | 1318-1321 | Protein | denotes | p65 |
T4283 | 1984-1987 | Protein | denotes | p50 |
T4284 | 1988-1991 | Protein | denotes | p65 |
T4285 | 2033-2037 | Protein | denotes | IκBα |
T4286 | 2044-2048 | Positive_regulation | denotes | Upon |
T4287 | 2044-2048 | Positive_regulation | denotes | Upon |
T4288 | 2091-2095 | Protein | denotes | IκBα |
T4289 | 2099-2113 | Phosphorylation | denotes | phosphorylated |
T4290 | 2134-2142 | Protein_catabolism | denotes | degraded |
T4291 | 2160-2163 | Protein | denotes | p50 |
T4292 | 2164-2167 | Protein | denotes | p65 |
T4293 | 2240-2247 | Localization | denotes | release |
T4294 | 2253-2257 | Protein | denotes | IκBα |
T4295 | 2265-2268 | Protein | denotes | p65 |
T4296 | 2281-2312 | Protein_modification | denotes | post-translational modification |
T4297 | 2363-2366 | Protein | denotes | p65 |
T4298 | 2367-2382 | Phosphorylation | denotes | phosphorylation |
T4299 | 2506-2521 | Phosphorylation | denotes | phosphorylation |
T4300 | 2506-2521 | Phosphorylation | denotes | phosphorylation |
T4301 | 2506-2521 | Phosphorylation | denotes | phosphorylation |
T4302 | 2531-2534 | Protein | denotes | p65 |
T4303 | 2538-2544 | Entity | denotes | Ser276 |
T4304 | 2546-2552 | Entity | denotes | Ser529 |
T4305 | 2556-2562 | Entity | denotes | Ser536 |
T4306 | 2677-2683 | Entity | denotes | Ser276 |
T4307 | 2693-2696 | Protein | denotes | p65 |
T4308 | 2700-2714 | Phosphorylation | denotes | phosphorylated |
T4309 | 2718-2722 | Protein | denotes | MSK1 |
T4310 | 2858-2873 | Phosphorylation | denotes | phosphorylation |
T4311 | 2858-2873 | Phosphorylation | denotes | phosphorylation |
T4312 | 2877-2883 | Entity | denotes | Ser276 |
T4313 | 2888-2894 | Entity | denotes | Ser536 |
T4314 | 2903-2912 | Regulation | denotes | regulated |
T4315 | 2903-2912 | Regulation | denotes | regulated |
T4316 | 2948-2952 | Protein | denotes | IKKβ |
T4317 | 3001-3004 | Protein | denotes | p65 |
T4318 | 3023-3037 | Phosphorylation | denotes | phosphorylated |
T4319 | 3041-3047 | Entity | denotes | Ser536 |
T4320 | 3068-3071 | Protein | denotes | p65 |
T4321 | 3072-3079 | Entity | denotes | nuclear |
T4322 | 3080-3093 | Localization | denotes | translocation |
T4323 | 3172-3175 | Protein | denotes | p65 |
T4324 | 3176-3191 | Phosphorylation | denotes | phosphorylation |
T4325 | 3195-3201 | Entity | denotes | Ser276 |
T4326 | 3275-3290 | Phosphorylation | denotes | phosphorylation |
T4327 | 3294-3300 | Entity | denotes | Ser276 |
T4328 | 3310-3313 | Protein | denotes | p65 |
T4329 | 3314-3316 | Positive_regulation | denotes | by |
T4330 | 3362-3366 | Protein | denotes | p300 |
T4331 | 3503-3514 | Positive_regulation | denotes | stabilizing |
T4332 | 3515-3519 | Protein | denotes | IκBα |
T4333 | 3575-3580 | Protein | denotes | Pim-1 |
T4334 | 3590-3604 | Phosphorylation | denotes | phosphorylates |
T4335 | 3611-3614 | Protein | denotes | p65 |
T4336 | 3618-3624 | Entity | denotes | Ser276 |
T4337 | 3848-3853 | Protein | denotes | M-CSF |
T4338 | 4209-4210 | Protein | denotes | α |
T4339 | 4211-4213 | Protein | denotes | βI |
T4340 | 4214-4217 | Protein | denotes | βII |
T4341 | 4222-4223 | Protein | denotes | γ |
T4342 | 4277-4278 | Protein | denotes | δ |
T4343 | 4280-4281 | Protein | denotes | ε |
T4344 | 4283-4284 | Protein | denotes | η |
T4345 | 4286-4287 | Protein | denotes | θ |
T4346 | 4292-4293 | Protein | denotes | μ |
T4347 | 4329-4330 | Protein | denotes | ξ |
T4348 | 4332-4333 | Protein | denotes | ι |
T4349 | 4338-4339 | Protein | denotes | λ |
T4350 | 4446-4450 | Protein | denotes | PKCα |
T4351 | 4451-4456 | Protein | denotes | PKCβI |
T4352 | 4461-4467 | Protein | denotes | PKCβII |
T4353 | 4485-4489 | Protein | denotes | PKCδ |
T4354 | 4494-4498 | Protein | denotes | PKCε |
T4355 | 4616-4620 | Protein | denotes | PKCα |
T4356 | 4621-4628 | Positive_regulation | denotes | induces |
T4357 | 4621-4628 | Positive_regulation | denotes | induces |
T4358 | 4621-4628 | Positive_regulation | denotes | induces |
T4359 | 4629-4634 | Protein | denotes | IL-1α |
T4360 | 4636-4640 | Protein | denotes | iNOS |
T4361 | 4645-4649 | Protein | denotes | TNFα |
T4362 | 4655-4665 | Transcription | denotes | production |
T4363 | 4655-4665 | Transcription | denotes | production |
T4364 | 4655-4665 | Transcription | denotes | production |
T4365 | 4784-4788 | Protein | denotes | PKCα |
T4366 | 4833-4837 | Protein | denotes | PKCα |
T4367 | 4841-4854 | Positive_regulation | denotes | overexpressed |
T4368 | 4951-4961 | Negative_regulation | denotes | inhibition |
T4369 | 4965-4969 | Protein | denotes | PKCα |
T4370 | 4978-4982 | Protein | denotes | PKCδ |
T4371 | 5098-5102 | Protein | denotes | PKCδ |
T4372 | 5169-5173 | Protein | denotes | PKCδ |
T4373 | 5183-5197 | Phosphorylation | denotes | phosphorylates |
T4374 | 5198-5207 | Protein | denotes | caspase-3 |
T4375 | 5320-5324 | Protein | denotes | PKCε |
T4376 | 5440-5445 | Protein | denotes | M-CSF |
T4377 | 5557-5562 | Protein | denotes | M-CSF |
T4378 | 5695-5700 | Protein | denotes | M-CSF |
T4379 | 6078-6083 | Protein | denotes | M-CSF |
T4380 | 6137-6142 | Protein | denotes | M-CSF |
T4381 | 6307-6329 | Protein | denotes | dominant negative PKCα |
T4382 | 6344-6354 | Protein | denotes | PKCα siRNA |
T4383 | 6373-6382 | Regulation | denotes | regulated |
T4384 | 6419-6434 | Phosphorylation | denotes | phosphorylation |
T4385 | 6438-6444 | Entity | denotes | Ser276 |
T4386 | 6454-6457 | Protein | denotes | p65 |
T4387 | 6473-6478 | Protein | denotes | M-CSF |
T4388 | 6479-6488 | Regulation | denotes | dependent |
T4389 | 6570-6579 | Regulation | denotes | regulated |
T4390 | 6580-6595 | Phosphorylation | denotes | phosphorylation |
T4391 | 6599-6605 | Entity | denotes | Ser276 |
T4392 | 6615-6618 | Protein | denotes | p65 |
R3218 | T4263 | T4262 | equivalentTo | M-CSF,Macrophage colony-stimulating factor |
R3219 | T4266 | T4267 | equivalentTo | RelA,p65 |
R3228 | T4277 | T4276 | themeOf | p65,lacking |
R3245 | T4278 | T4279 | themeOf | p65,null |
R3248 | T4282 | T4281 | themeOf | p65,overexpressing |
R3251 | T4288 | T4290 | themeOf | IκBα,degraded |
R3254 | T4288 | T4289 | themeOf | IκBα,phosphorylated |
R3255 | T4289 | T4286 | themeOf | phosphorylated,Upon |
R3256 | T4290 | T4287 | themeOf | degraded,Upon |
R3257 | T4295 | T4293 | themeOf | p65,release |
R3261 | T4295 | T4296 | themeOf | p65,post-translational modification |
R3262 | T4297 | T4298 | themeOf | p65,phosphorylation |
R3266 | T4303 | T4299 | themeOf | Ser276,phosphorylation |
R3272 | T4303 | T4302 | partOf | Ser276,p65 |
R3273 | T4304 | T4300 | themeOf | Ser529,phosphorylation |
R3275 | T4304 | T4302 | partOf | Ser529,p65 |
R3277 | T4305 | T4301 | themeOf | Ser536,phosphorylation |
R3278 | T4305 | T4302 | partOf | Ser536,p65 |
R3279 | T4306 | T4308 | themeOf | Ser276,phosphorylated |
R3280 | T4306 | T4307 | partOf | Ser276,p65 |
R3281 | T4309 | T4308 | causeOf | MSK1,phosphorylated |
R3286 | T4310 | T4314 | themeOf | phosphorylation,regulated |
R3287 | T4311 | T4315 | themeOf | phosphorylation,regulated |
R3288 | T4312 | T4310 | themeOf | Ser276,phosphorylation |
R3289 | T4312 | T4307 | partOf | Ser276,p65 |
R3290 | T4313 | T4311 | themeOf | Ser536,phosphorylation |
R3291 | T4313 | T4307 | partOf | Ser536,p65 |
R3292 | T4316 | T4314 | causeOf | IKKβ,regulated |
R3293 | T4355 | T4356 | causeOf | PKCα,induces |
R3294 | T4355 | T4357 | causeOf | PKCα,induces |
R3295 | T4355 | T4358 | causeOf | PKCα,induces |
R3296 | T4316 | T4315 | causeOf | IKKβ,regulated |
R3297 | T4319 | T4318 | themeOf | Ser536,phosphorylated |
R3298 | T4359 | T4362 | themeOf | IL-1α,production |
R3299 | T4360 | T4363 | themeOf | iNOS,production |
R3300 | T4361 | T4364 | themeOf | TNFα,production |
R3301 | T4362 | T4356 | themeOf | production,induces |
R3302 | T4363 | T4357 | themeOf | production,induces |
R3303 | T4319 | T4317 | partOf | Ser536,p65 |
R3304 | T4364 | T4358 | themeOf | production,induces |
R3305 | T4320 | T4322 | themeOf | p65,translocation |
R3306 | T4366 | T4367 | themeOf | PKCα,overexpressed |
R3307 | T4321 | T4322 | locationOf | nuclear,translocation |
R3308 | T4369 | T4368 | themeOf | PKCα,inhibition |
R3309 | T4325 | T4324 | themeOf | Ser276,phosphorylation |
R3310 | T4372 | T4373 | causeOf | PKCδ,phosphorylates |
R3311 | T4374 | T4373 | themeOf | caspase-3,phosphorylates |
R3312 | T4325 | T4323 | partOf | Ser276,p65 |
R3313 | T4326 | T4329 | themeOf | phosphorylation,by |
R3314 | T4327 | T4326 | themeOf | Ser276,phosphorylation |
R3315 | T4327 | T4328 | partOf | Ser276,p65 |
R3316 | T4383 | T4388 | themeOf | regulated,dependent |
R3317 | T4332 | T4331 | themeOf | IκBα,stabilizing |
R3318 | T4384 | T4383 | themeOf | phosphorylation,regulated |
R3319 | T4385 | T4384 | themeOf | Ser276,phosphorylation |
R3320 | T4385 | T4386 | partOf | Ser276,p65 |
R3321 | T4387 | T4388 | causeOf | M-CSF,dependent |
R3322 | T4333 | T4334 | causeOf | Pim-1,phosphorylates |
R3323 | T4336 | T4334 | themeOf | Ser276,phosphorylates |
R3324 | T4390 | T4389 | themeOf | phosphorylation,regulated |
R3325 | T4391 | T4390 | themeOf | Ser276,phosphorylation |
R3326 | T4391 | T4392 | partOf | Ser276,p65 |
R3327 | T4336 | T4335 | partOf | Ser276,p65 |
ICD10
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T3588 | 389-404 | http://purl.bioontology.org/ontology/ICD10/I70 | denotes | atherosclerosis |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T3618 | 302-306 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T3619 | 761-765 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T3620 | 1371-1375 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T3621 | 1390-1394 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T3622 | 1613-1617 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T3623 | 1756-1760 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T3624 | 2461-2465 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T3625 | 4020-4024 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T3626 | 4046-4050 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T3627 | 4580-4584 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T3628 | 5131-5135 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T3629 | 5846-5850 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T3630 | 6183-6187 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T3631 | 1613-1625 | http://purl.obolibrary.org/obo/GO_0009986 | denotes | cell surface |
T3632 | 2022-2029 | http://purl.obolibrary.org/obo/GO_0005829 | denotes | cytosol |
T3633 | 2190-2197 | http://purl.obolibrary.org/obo/GO_0005634 | denotes | nucleus |
T3634 | 2939-2942 | http://purl.obolibrary.org/obo/GO_0005952 | denotes | PKA |
T3635 | 3317-3320 | http://purl.obolibrary.org/obo/GO_0005952 | denotes | PKA |
T3636 | 3455-3458 | http://purl.obolibrary.org/obo/GO_0005952 | denotes | PKA |
T3637 | 3661-3671 | http://purl.obolibrary.org/obo/GO_0000502 | denotes | proteasome |
GO-MF
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T3589 | 2939-2942 | http://purl.obolibrary.org/obo/GO_0004691 | denotes | PKA |
T3590 | 3317-3320 | http://purl.obolibrary.org/obo/GO_0004691 | denotes | PKA |
T3591 | 3455-3458 | http://purl.obolibrary.org/obo/GO_0004691 | denotes | PKA |
T3592 | 3334-3360 | http://purl.obolibrary.org/obo/GO_0003713 | denotes | transcription co-activator |
T3593 | 3651-3660 | http://purl.obolibrary.org/obo/GO_0031386 | denotes | ubiquitin |
T3594 | 3840-3843 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
T3595 | 3883-3886 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
T3596 | 4145-4148 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
T3597 | 4432-4435 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
T3598 | 5315-5318 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
T3599 | 5574-5577 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
T3600 | 5652-5655 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
T3601 | 5794-5797 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
T3602 | 6032-6035 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
T3603 | 6291-6294 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
T3604 | 4446-4450 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCα |
T3605 | 4616-4620 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCα |
T3606 | 4784-4788 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCα |
T3607 | 4833-4837 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCα |
T3608 | 4965-4969 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCα |
T3609 | 6325-6329 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCα |
T3610 | 6344-6348 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCα |
T3611 | 4485-4489 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCδ |
T3612 | 4978-4982 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCδ |
T3613 | 5098-5102 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCδ |
T3614 | 4494-4498 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCε |
T3615 | 5320-5324 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCε |
T3616 | 5617-5628 | http://purl.obolibrary.org/obo/GO_0003677 | denotes | DNA binding |
T3617 | 5621-5628 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T4585 | 142-151 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T4586 | 5239-5248 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T4587 | 643-656 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
T4588 | 2330-2343 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
T4589 | 2816-2829 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
T4590 | 3334-3347 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
T4591 | 3402-3415 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
T4592 | 6165-6178 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
T4593 | 6526-6541 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcriptional |
T4594 | 724-732 | http://purl.obolibrary.org/obo/GO_0007349 | denotes | cellular |
T4595 | 3104-3112 | http://purl.obolibrary.org/obo/GO_0007349 | denotes | cellular |
T4596 | 1169-1178 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T4597 | 5947-5955 | http://purl.obolibrary.org/obo/GO_0007349 | denotes | cellular |
T4598 | 733-742 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
T4599 | 5370-5379 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
T4600 | 744-759 | http://purl.obolibrary.org/obo/GO_0006950 | denotes | stress response |
T4601 | 761-772 | http://purl.obolibrary.org/obo/GO_0016049 | denotes | cell growth |
T4602 | 4046-4057 | http://purl.obolibrary.org/obo/GO_0016049 | denotes | cell growth |
T4603 | 766-772 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
T4604 | 4051-4057 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
T4605 | 804-816 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T4606 | 1053-1076 | http://purl.obolibrary.org/obo/GO_0032502 | denotes | developmental processes |
T4607 | 1263-1272 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T4608 | 4089-4100 | http://purl.obolibrary.org/obo/GO_0032502 | denotes | development |
T4609 | 1346-1362 | http://purl.obolibrary.org/obo/GO_0032088 | denotes | inhibiting NF-κB |
T4610 | 3459-3473 | http://purl.obolibrary.org/obo/GO_0032088 | denotes | inhibits NF-κB |
T4611 | 1346-1362 | http://purl.obolibrary.org/obo/GO_0007252 | denotes | inhibiting NF-κB |
T4612 | 3459-3473 | http://purl.obolibrary.org/obo/GO_0007252 | denotes | inhibits NF-κB |
T4613 | 1371-1381 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | cell death |
T4614 | 1376-1381 | http://purl.obolibrary.org/obo/GO_0016265 | denotes | death |
T4615 | 1913-1921 | http://purl.obolibrary.org/obo/GO_0048286 | denotes | alveolar |
T4616 | 2003-2014 | http://purl.obolibrary.org/obo/GO_0051235 | denotes | sequestered |
T4617 | 2134-2142 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degraded |
T4618 | 4993-5002 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T4619 | 3672-3683 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degradation |
T4620 | 2281-2312 | http://purl.obolibrary.org/obo/GO_0043687 | denotes | post-translational modification |
T4621 | 2281-2312 | http://purl.obolibrary.org/obo/GO_1901873 | denotes | post-translational modification |
T4622 | 2281-2312 | http://purl.obolibrary.org/obo/GO_1901874 | denotes | post-translational modification |
T4623 | 2367-2382 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T4624 | 2506-2521 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T4625 | 2858-2873 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T4626 | 3176-3191 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T4627 | 3275-3290 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T4628 | 5239-5248 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T4629 | 3704-3719 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T4630 | 6419-6434 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T4631 | 6580-6595 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T4632 | 2939-2942 | http://purl.obolibrary.org/obo/GO_0004691 | denotes | PKA |
T4633 | 3317-3320 | http://purl.obolibrary.org/obo/GO_0004691 | denotes | PKA |
T4634 | 3455-3458 | http://purl.obolibrary.org/obo/GO_0004691 | denotes | PKA |
T4635 | 3334-3360 | http://purl.obolibrary.org/obo/GO_0003713 | denotes | transcription co-activator |
T4636 | 3484-3499 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
T4637 | 6399-6414 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
T4638 | 3661-3683 | http://purl.obolibrary.org/obo/GO_1903009 | denotes | proteasome degradation |
T4639 | 142-151 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T4640 | 3767-3782 | http://purl.obolibrary.org/obo/GO_2000144 | denotes | transactivation |
T4641 | 1169-1178 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T4642 | 1263-1272 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T4643 | 5361-5392 | http://purl.obolibrary.org/obo/GO_1900171 | denotes | mediated signaling in activated |
T4644 | 5361-5392 | http://purl.obolibrary.org/obo/GO_0050850 | denotes | mediated signaling in activated |
T4645 | 5361-5392 | http://purl.obolibrary.org/obo/GO_1900459 | denotes | mediated signaling in activated |
T4646 | 4993-5002 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T4647 | 5361-5392 | http://purl.obolibrary.org/obo/GO_1902661 | denotes | mediated signaling in activated |
T4648 | 6032-6053 | http://purl.obolibrary.org/obo/GO_1900019 | denotes | PKC in the regulation |
T4649 | 6043-6053 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
UBERON-AE
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T960 | 43-54 | http://purl.obolibrary.org/obo/UBERON_0002371 | denotes | bone marrow |
T961 | 72-77 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T962 | 117-122 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | serum |
T963 | 440-446 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
T964 | 1133-1142 | http://purl.obolibrary.org/obo/UBERON_2000106 | denotes | extensive |
T965 | 1143-1148 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
T966 | 4902-4907 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
T967 | 4913-4917 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
bionlp-st-ge-2016-coref
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T3306 | 2895-2899 | Anaphor | denotes | that |
T3307 | 2858-2873 | Antecedent | denotes | phosphorylation |
T3304 | 2236-2239 | Anaphor | denotes | its |
T3305 | 2265-2268 | Antecedent | denotes | p65 |
R2878 | T3304 | T3305 | boundBy | its,p65 |
R2880 | T3306 | T3307 | boundBy | that,phosphorylation |
pmc-enju-pas
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2187 | 13-22 | NN | denotes | Monocytes |
T2188 | 23-26 | VB | denotes | are |
T2189 | 27-35 | VB | denotes | produced |
T2190 | 36-38 | IN | denotes | in |
T2191 | 39-42 | DT | denotes | the |
T2192 | 43-47 | NN | denotes | bone |
T2193 | 48-54 | NN | denotes | marrow |
T2194 | 55-58 | CC | denotes | and |
T2195 | 59-68 | VB | denotes | circulate |
T2196 | 69-71 | IN | denotes | in |
T2197 | 72-77 | NN | denotes | blood |
T2198 | 78-81 | IN | denotes | for |
T2199 | 82-87 | CD | denotes | 24–48 |
T2200 | 88-93 | NN | denotes | hours |
T2201 | 94-95 | -LRB- | denotes | [ |
T2202 | 95-96 | CD | denotes | 1 |
T2203 | 96-97 | -RRB- | denotes | ] |
T2204 | 99-101 | IN | denotes | In |
T2205 | 102-105 | DT | denotes | the |
T2206 | 106-113 | NN | denotes | absence |
T2207 | 114-116 | IN | denotes | of |
T2208 | 117-122 | NN | denotes | serum |
T2209 | 122-123 | -COMMA- | denotes | , |
T2210 | 124-133 | NN | denotes | monocytes |
T2211 | 134-137 | VB | denotes | die |
T2212 | 138-141 | IN | denotes | via |
T2213 | 142-151 | NN | denotes | apoptosis |
T2214 | 152-153 | -LRB- | denotes | [ |
T2215 | 153-154 | CD | denotes | 1 |
T2216 | 154-155 | -RRB- | denotes | ] |
T2217 | 155-156 | -COMMA- | denotes | , |
T2218 | 157-158 | -LRB- | denotes | [ |
T2219 | 158-159 | CD | denotes | 2 |
T2220 | 159-160 | -RRB- | denotes | ] |
T2221 | 162-172 | NN | denotes | Macrophage |
T2222 | 173-191 | JJ | denotes | colony-stimulating |
T2223 | 192-198 | NN | denotes | factor |
T2224 | 199-200 | -LRB- | denotes | ( |
T2225 | 200-205 | NN | denotes | M-CSF |
T2226 | 205-206 | -RRB- | denotes | ) |
T2227 | 207-217 | VB | denotes | stimulates |
T2228 | 218-229 | JJ | denotes | mononuclear |
T2229 | 230-239 | NN | denotes | phagocyte |
T2230 | 240-248 | NN | denotes | survival |
T2231 | 249-252 | CC | denotes | and |
T2232 | 253-268 | NN | denotes | differentiation |
T2233 | 269-270 | -LRB- | denotes | [ |
T2234 | 270-271 | CD | denotes | 3 |
T2235 | 271-272 | -RRB- | denotes | ] |
T2236 | 274-285 | RB | denotes | Importantly |
T2237 | 285-286 | -COMMA- | denotes | , |
T2238 | 287-301 | JJ | denotes | M-CSF-mediated |
T2239 | 302-306 | NN | denotes | cell |
T2240 | 307-315 | NN | denotes | survival |
T2241 | 316-319 | CC | denotes | and |
T2242 | 320-330 | NN | denotes | activation |
T2243 | 331-333 | VB | denotes | is |
T2244 | 334-344 | VB | denotes | associated |
T2245 | 345-349 | IN | denotes | with |
T2246 | 350-351 | DT | denotes | a |
T2247 | 352-359 | NN | denotes | variety |
T2248 | 360-362 | IN | denotes | of |
T2249 | 363-368 | JJ | denotes | human |
T2250 | 369-377 | NN | denotes | diseases |
T2251 | 377-378 | -COMMA- | denotes | , |
T2252 | 379-388 | VB | denotes | including |
T2253 | 389-404 | NN | denotes | atherosclerosis |
T2254 | 404-405 | -COMMA- | denotes | , |
T2255 | 406-416 | NN | denotes | transplant |
T2256 | 417-425 | JJ | denotes | vascular |
T2257 | 426-435 | NN | denotes | sclerosis |
T2258 | 436-439 | CC | denotes | and |
T2259 | 440-446 | NN | denotes | breast |
T2260 | 447-453 | NN | denotes | cancer |
T2261 | 454-464 | NN | denotes | metastasis |
T2262 | 465-466 | -LRB- | denotes | [ |
T2263 | 466-467 | CD | denotes | 4 |
T2264 | 467-468 | -RRB- | denotes | ] |
T2265 | 468-469 | -COMMA- | denotes | , |
T2266 | 470-471 | -LRB- | denotes | [ |
T2267 | 471-472 | CD | denotes | 5 |
T2268 | 472-473 | -RRB- | denotes | ] |
T2269 | 473-474 | -COMMA- | denotes | , |
T2270 | 475-476 | -LRB- | denotes | [ |
T2271 | 476-477 | CD | denotes | 6 |
T2272 | 477-478 | -RRB- | denotes | ] |
T2273 | 480-482 | PRP | denotes | We |
T2274 | 483-493 | RB | denotes | previously |
T2275 | 494-504 | VB | denotes | identified |
T2276 | 505-509 | IN | denotes | that |
T2277 | 510-515 | NN | denotes | NF-κB |
T2278 | 516-526 | NN | denotes | activation |
T2279 | 527-529 | VB | denotes | is |
T2280 | 530-539 | JJ | denotes | important |
T2281 | 540-542 | IN | denotes | in |
T2282 | 543-556 | JJ | denotes | M-CSF-induced |
T2283 | 557-565 | NN | denotes | monocyte |
T2284 | 566-574 | NN | denotes | survival |
T2285 | 575-576 | -LRB- | denotes | [ |
T2286 | 576-577 | CD | denotes | 7 |
T2287 | 577-578 | -RRB- | denotes | ] |
T2288 | 580-582 | IN | denotes | In |
T2289 | 583-591 | NN | denotes | addition |
T2290 | 592-594 | TO | denotes | to |
T2291 | 595-598 | PRP-DOLLAR- | denotes | its |
T2292 | 599-603 | NN | denotes | role |
T2293 | 604-606 | IN | denotes | in |
T2294 | 607-618 | JJ | denotes | mononuclear |
T2295 | 619-628 | NN | denotes | phagocyte |
T2296 | 629-637 | NN | denotes | survival |
T2297 | 637-638 | -COMMA- | denotes | , |
T2298 | 639-642 | DT | denotes | the |
T2299 | 643-656 | NN | denotes | transcription |
T2300 | 657-663 | NN | denotes | factor |
T2301 | 664-669 | NN | denotes | NF-κB |
T2302 | 670-679 | VB | denotes | regulates |
T2303 | 680-688 | JJ | denotes | numerous |
T2304 | 689-694 | NN | denotes | genes |
T2305 | 695-699 | WDT | denotes | that |
T2306 | 700-704 | VB | denotes | play |
T2307 | 705-714 | JJ | denotes | important |
T2308 | 715-720 | NN | denotes | roles |
T2309 | 721-723 | IN | denotes | in |
T2310 | 724-732 | JJ | denotes | cellular |
T2311 | 733-742 | NN | denotes | signaling |
T2312 | 742-743 | -COMMA- | denotes | , |
T2313 | 744-750 | NN | denotes | stress |
T2314 | 751-759 | NN | denotes | response |
T2315 | 759-760 | -COMMA- | denotes | , |
T2316 | 761-765 | NN | denotes | cell |
T2317 | 766-772 | NN | denotes | growth |
T2318 | 772-773 | -COMMA- | denotes | , |
T2319 | 774-782 | NN | denotes | survival |
T2320 | 782-783 | -COMMA- | denotes | , |
T2321 | 784-799 | NN | denotes | differentiation |
T2322 | 800-803 | CC | denotes | and |
T2323 | 804-816 | NN | denotes | inflammation |
T2324 | 817-818 | -LRB- | denotes | [ |
T2325 | 818-819 | CD | denotes | 8 |
T2326 | 819-820 | -RRB- | denotes | ] |
T2327 | 822-827 | EX | denotes | There |
T2328 | 828-831 | VB | denotes | are |
T2329 | 832-836 | CD | denotes | five |
T2330 | 837-844 | NN | denotes | members |
T2331 | 845-847 | IN | denotes | in |
T2332 | 848-851 | DT | denotes | the |
T2333 | 852-857 | NN | denotes | NF-κB |
T2334 | 858-864 | NN | denotes | family |
T2335 | 864-865 | -COLON- | denotes | : |
T2336 | 866-874 | NN | denotes | RelA/p65 |
T2337 | 874-875 | -COMMA- | denotes | , |
T2338 | 876-879 | NN | denotes | p50 |
T2339 | 879-880 | -COMMA- | denotes | , |
T2340 | 881-884 | NN | denotes | p52 |
T2341 | 884-885 | -COMMA- | denotes | , |
T2342 | 886-891 | NN | denotes | c-Rel |
T2343 | 892-895 | CC | denotes | and |
T2344 | 896-900 | NN | denotes | RelB |
T2345 | 902-905 | DT | denotes | The |
T2346 | 906-910 | RB | denotes | most |
T2347 | 911-917 | JJ | denotes | common |
T2348 | 918-928 | VB | denotes | activating |
T2349 | 929-936 | NN | denotes | complex |
T2350 | 937-939 | VB | denotes | is |
T2351 | 940-943 | DT | denotes | the |
T2352 | 944-951 | NN | denotes | p50/p65 |
T2353 | 952-963 | NN | denotes | heterodimer |
T2354 | 963-964 | -COMMA- | denotes | , |
T2355 | 965-971 | VB | denotes | driven |
T2356 | 972-974 | IN | denotes | by |
T2357 | 975-978 | DT | denotes | the |
T2358 | 979-989 | NN | denotes | activation |
T2359 | 990-996 | NN | denotes | domain |
T2360 | 997-999 | IN | denotes | in |
T2361 | 1000-1003 | DT | denotes | the |
T2362 | 1004-1009 | NN | denotes | NF-κB |
T2363 | 1010-1013 | NN | denotes | p65 |
T2364 | 1014-1021 | NN | denotes | subunit |
T2365 | 1023-1028 | NN | denotes | NF-κB |
T2366 | 1029-1032 | NN | denotes | p65 |
T2367 | 1033-1042 | VB | denotes | regulates |
T2368 | 1043-1052 | JJ | denotes | important |
T2369 | 1053-1066 | JJ | denotes | developmental |
T2370 | 1067-1076 | NN | denotes | processes |
T2371 | 1077-1078 | -LRB- | denotes | [ |
T2372 | 1078-1079 | CD | denotes | 9 |
T2373 | 1079-1080 | -RRB- | denotes | ] |
T2374 | 1080-1081 | -COMMA- | denotes | , |
T2375 | 1082-1083 | -LRB- | denotes | [ |
T2376 | 1083-1085 | CD | denotes | 10 |
T2377 | 1085-1086 | -RRB- | denotes | ] |
T2378 | 1088-1092 | NN | denotes | Mice |
T2379 | 1093-1100 | VB | denotes | lacking |
T2380 | 1101-1106 | NN | denotes | NF-κB |
T2381 | 1107-1110 | NN | denotes | p65 |
T2382 | 1111-1114 | NN | denotes | die |
T2383 | 1115-1117 | IN | denotes | in |
T2384 | 1118-1123 | NN | denotes | utero |
T2385 | 1124-1127 | CC | denotes | and |
T2386 | 1128-1132 | VB | denotes | have |
T2387 | 1133-1142 | JJ | denotes | extensive |
T2388 | 1143-1148 | NN | denotes | liver |
T2389 | 1149-1155 | NN | denotes | damage |
T2390 | 1156-1159 | IN | denotes | via |
T2391 | 1160-1168 | VB | denotes | enhanced |
T2392 | 1169-1178 | NN | denotes | apoptosis |
T2393 | 1179-1180 | -LRB- | denotes | [ |
T2394 | 1180-1181 | CD | denotes | 9 |
T2395 | 1181-1182 | -RRB- | denotes | ] |
T2396 | 1184-1193 | JJ | denotes | Embryonic |
T2397 | 1194-1205 | NN | denotes | macrophages |
T2398 | 1206-1210 | IN | denotes | from |
T2399 | 1211-1216 | NN | denotes | NF-κB |
T2400 | 1217-1220 | NN | denotes | p65 |
T2401 | 1221-1225 | JJ | denotes | null |
T2402 | 1226-1230 | NN | denotes | mice |
T2403 | 1231-1234 | VB | denotes | are |
T2404 | 1235-1246 | JJ | denotes | susceptible |
T2405 | 1247-1249 | TO | denotes | to |
T2406 | 1250-1262 | JJ | denotes | TNFα-induced |
T2407 | 1263-1272 | NN | denotes | apoptosis |
T2408 | 1273-1278 | WDT | denotes | which |
T2409 | 1279-1281 | VB | denotes | is |
T2410 | 1282-1289 | VB | denotes | rescued |
T2411 | 1290-1292 | IN | denotes | by |
T2412 | 1293-1307 | VB | denotes | overexpressing |
T2413 | 1308-1311 | DT | denotes | the |
T2414 | 1312-1317 | NN | denotes | NF-κB |
T2415 | 1318-1321 | NN | denotes | p65 |
T2416 | 1322-1329 | NN | denotes | subunit |
T2417 | 1330-1331 | -LRB- | denotes | [ |
T2418 | 1331-1333 | CD | denotes | 10 |
T2419 | 1333-1334 | -RRB- | denotes | ] |
T2420 | 1336-1344 | RB | denotes | Moreover |
T2421 | 1344-1345 | -COMMA- | denotes | , |
T2422 | 1346-1356 | VB | denotes | inhibiting |
T2423 | 1357-1362 | NN | denotes | NF-κB |
T2424 | 1363-1370 | VB | denotes | induces |
T2425 | 1371-1375 | NN | denotes | cell |
T2426 | 1376-1381 | NN | denotes | death |
T2427 | 1382-1384 | IN | denotes | in |
T2428 | 1385-1389 | JJ | denotes | many |
T2429 | 1390-1394 | NN | denotes | cell |
T2430 | 1395-1400 | NN | denotes | types |
T2431 | 1401-1404 | CC | denotes | and |
T2432 | 1405-1425 | JJ | denotes | cytokine-independent |
T2433 | 1426-1434 | NN | denotes | survival |
T2434 | 1435-1437 | VB | denotes | is |
T2435 | 1438-1446 | VB | denotes | mediated |
T2436 | 1447-1449 | IN | denotes | by |
T2437 | 1450-1464 | RB | denotes | constitutively |
T2438 | 1465-1471 | JJ | denotes | active |
T2439 | 1472-1477 | NN | denotes | NF-κB |
T2440 | 1478-1480 | IN | denotes | in |
T2441 | 1481-1487 | JJ | denotes | murine |
T2442 | 1488-1499 | NN | denotes | macrophages |
T2443 | 1500-1501 | -LRB- | denotes | [ |
T2444 | 1501-1503 | CD | denotes | 11 |
T2445 | 1503-1504 | -RRB- | denotes | ] |
T2446 | 1506-1508 | IN | denotes | In |
T2447 | 1509-1518 | NN | denotes | monocytes |
T2448 | 1519-1522 | CC | denotes | and |
T2449 | 1523-1534 | NN | denotes | macrophages |
T2450 | 1534-1535 | -COMMA- | denotes | , |
T2451 | 1536-1541 | NN | denotes | NF-κB |
T2452 | 1542-1544 | VB | denotes | is |
T2453 | 1545-1547 | DT | denotes | an |
T2454 | 1548-1557 | JJ | denotes | important |
T2455 | 1558-1573 | JJ | denotes | transcriptional |
T2456 | 1574-1580 | NN | denotes | factor |
T2457 | 1581-1584 | IN | denotes | for |
T2458 | 1585-1595 | NN | denotes | expression |
T2459 | 1596-1598 | IN | denotes | of |
T2460 | 1599-1608 | NN | denotes | cytokines |
T2461 | 1609-1612 | CC | denotes | and |
T2462 | 1613-1617 | NN | denotes | cell |
T2463 | 1618-1625 | NN | denotes | surface |
T2464 | 1626-1635 | NN | denotes | receptors |
T2465 | 1636-1637 | -LRB- | denotes | [ |
T2466 | 1637-1639 | CD | denotes | 12 |
T2467 | 1639-1640 | -RRB- | denotes | ] |
T2468 | 1642-1649 | RB | denotes | However |
T2469 | 1649-1650 | -COMMA- | denotes | , |
T2470 | 1651-1657 | IN | denotes | unlike |
T2471 | 1658-1665 | VB | denotes | resting |
T2472 | 1666-1673 | NN | denotes | T-cells |
T2473 | 1673-1674 | -COMMA- | denotes | , |
T2474 | 1675-1680 | NN | denotes | NF-κB |
T2475 | 1681-1683 | VB | denotes | is |
T2476 | 1684-1698 | RB | denotes | constitutively |
T2477 | 1699-1706 | JJ | denotes | present |
T2478 | 1707-1709 | IN | denotes | in |
T2479 | 1710-1713 | DT | denotes | the |
T2480 | 1714-1720 | NN | denotes | nuclei |
T2481 | 1721-1723 | IN | denotes | of |
T2482 | 1724-1731 | JJ | denotes | primary |
T2483 | 1732-1741 | NN | denotes | monocytes |
T2484 | 1742-1745 | CC | denotes | and |
T2485 | 1746-1755 | JJ | denotes | monocytic |
T2486 | 1756-1760 | NN | denotes | cell |
T2487 | 1761-1766 | NN | denotes | lines |
T2488 | 1767-1769 | IN | denotes | in |
T2489 | 1770-1773 | DT | denotes | the |
T2490 | 1774-1781 | NN | denotes | absence |
T2491 | 1782-1784 | IN | denotes | of |
T2492 | 1785-1794 | JJ | denotes | exogenous |
T2493 | 1795-1802 | NN | denotes | stimuli |
T2494 | 1803-1805 | IN | denotes | as |
T2495 | 1806-1818 | VB | denotes | demonstrated |
T2496 | 1819-1821 | IN | denotes | by |
T2497 | 1822-1830 | NN | denotes | mobility |
T2498 | 1831-1836 | NN | denotes | shift |
T2499 | 1837-1845 | NN | denotes | analysis |
T2500 | 1846-1847 | -LRB- | denotes | [ |
T2501 | 1847-1849 | CD | denotes | 13 |
T2502 | 1849-1850 | -RRB- | denotes | ] |
T2503 | 1852-1861 | RB | denotes | Similarly |
T2504 | 1861-1862 | -COMMA- | denotes | , |
T2505 | 1863-1877 | RB | denotes | constitutively |
T2506 | 1878-1884 | JJ | denotes | active |
T2507 | 1885-1890 | NN | denotes | NF-κB |
T2508 | 1891-1894 | VB | denotes | was |
T2509 | 1895-1903 | VB | denotes | observed |
T2510 | 1904-1906 | IN | denotes | in |
T2511 | 1907-1912 | JJ | denotes | human |
T2512 | 1913-1921 | JJ | denotes | alveolar |
T2513 | 1922-1933 | NN | denotes | macrophages |
T2514 | 1934-1935 | -LRB- | denotes | [ |
T2515 | 1935-1937 | CD | denotes | 14 |
T2516 | 1937-1938 | -RRB- | denotes | ] |
T2517 | 1940-1942 | IN | denotes | In |
T2518 | 1943-1946 | DT | denotes | the |
T2519 | 1947-1964 | JJ | denotes | classic/canonical |
T2520 | 1965-1972 | NN | denotes | pathway |
T2521 | 1972-1973 | -COMMA- | denotes | , |
T2522 | 1974-1977 | DT | denotes | the |
T2523 | 1978-1983 | NN | denotes | NF-κB |
T2524 | 1984-1991 | NN | denotes | p50/p65 |
T2525 | 1992-1999 | NN | denotes | complex |
T2526 | 2000-2002 | VB | denotes | is |
T2527 | 2003-2014 | VB | denotes | sequestered |
T2528 | 2015-2017 | IN | denotes | in |
T2529 | 2018-2021 | DT | denotes | the |
T2530 | 2022-2029 | NN | denotes | cytosol |
T2531 | 2030-2032 | IN | denotes | by |
T2532 | 2033-2037 | NNP | denotes | IκBα |
T2533 | 2038-2039 | -LRB- | denotes | [ |
T2534 | 2039-2041 | CD | denotes | 15 |
T2535 | 2041-2042 | -RRB- | denotes | ] |
T2536 | 2044-2048 | IN | denotes | Upon |
T2537 | 2049-2060 | NN | denotes | stimulation |
T2538 | 2061-2063 | IN | denotes | by |
T2539 | 2064-2073 | NN | denotes | cytokines |
T2540 | 2074-2076 | CC | denotes | or |
T2541 | 2077-2079 | NN | denotes | UV |
T2542 | 2080-2089 | NN | denotes | radiation |
T2543 | 2089-2090 | -COMMA- | denotes | , |
T2544 | 2091-2095 | NNP | denotes | IκBα |
T2545 | 2096-2098 | VB | denotes | is |
T2546 | 2099-2113 | VB | denotes | phosphorylated |
T2547 | 2113-2114 | -COMMA- | denotes | , |
T2548 | 2115-2128 | VB | denotes | ubiquitinated |
T2549 | 2128-2129 | -COMMA- | denotes | , |
T2550 | 2130-2133 | CC | denotes | and |
T2551 | 2134-2142 | VB | denotes | degraded |
T2552 | 2142-2143 | -COMMA- | denotes | , |
T2553 | 2144-2153 | VB | denotes | releasing |
T2554 | 2154-2159 | NN | denotes | NF-κB |
T2555 | 2160-2167 | NN | denotes | p50/p65 |
T2556 | 2168-2170 | TO | denotes | to |
T2557 | 2171-2182 | VB | denotes | translocate |
T2558 | 2183-2185 | TO | denotes | to |
T2559 | 2186-2189 | DT | denotes | the |
T2560 | 2190-2197 | NN | denotes | nucleus |
T2561 | 2198-2201 | CC | denotes | and |
T2562 | 2202-2215 | VB | denotes | transactivate |
T2563 | 2216-2222 | NN | denotes | target |
T2564 | 2223-2228 | NN | denotes | genes |
T2565 | 2230-2235 | IN | denotes | After |
T2566 | 2236-2239 | PRP-DOLLAR- | denotes | its |
T2567 | 2240-2247 | NN | denotes | release |
T2568 | 2248-2252 | IN | denotes | from |
T2569 | 2253-2257 | NN | denotes | IκBα |
T2570 | 2257-2258 | -COMMA- | denotes | , |
T2571 | 2259-2264 | NN | denotes | NF-κB |
T2572 | 2265-2268 | NN | denotes | p65 |
T2573 | 2269-2272 | MD | denotes | can |
T2574 | 2273-2280 | VB | denotes | undergo |
T2575 | 2281-2299 | JJ | denotes | post-translational |
T2576 | 2300-2312 | NN | denotes | modification |
T2577 | 2313-2315 | TO | denotes | to |
T2578 | 2316-2324 | VB | denotes | activate |
T2579 | 2325-2329 | NN | denotes | gene |
T2580 | 2330-2343 | NN | denotes | transcription |
T2581 | 2345-2348 | DT | denotes | The |
T2582 | 2349-2353 | NN | denotes | role |
T2583 | 2354-2356 | IN | denotes | of |
T2584 | 2357-2362 | NN | denotes | NF-κB |
T2585 | 2363-2366 | NN | denotes | p65 |
T2586 | 2367-2382 | NN | denotes | phosphorylation |
T2587 | 2383-2385 | IN | denotes | on |
T2588 | 2386-2391 | NN | denotes | NF-κB |
T2589 | 2392-2407 | JJ | denotes | transcriptional |
T2590 | 2408-2416 | NN | denotes | activity |
T2591 | 2417-2423 | VB | denotes | varies |
T2592 | 2424-2426 | IN | denotes | by |
T2593 | 2427-2435 | NN | denotes | stimulus |
T2594 | 2435-2436 | -COMMA- | denotes | , |
T2595 | 2437-2441 | NN | denotes | time |
T2596 | 2442-2444 | IN | denotes | of |
T2597 | 2445-2456 | NN | denotes | stimulation |
T2598 | 2457-2460 | CC | denotes | and |
T2599 | 2461-2465 | NN | denotes | cell |
T2600 | 2466-2470 | NN | denotes | type |
T2601 | 2471-2472 | -LRB- | denotes | [ |
T2602 | 2472-2474 | CD | denotes | 16 |
T2603 | 2474-2475 | -RRB- | denotes | ] |
T2604 | 2477-2485 | JJ | denotes | Previous |
T2605 | 2486-2494 | NN | denotes | research |
T2606 | 2495-2500 | VB | denotes | shows |
T2607 | 2501-2505 | IN | denotes | that |
T2608 | 2506-2521 | NN | denotes | phosphorylation |
T2609 | 2522-2524 | IN | denotes | of |
T2610 | 2525-2530 | NN | denotes | NF-κB |
T2611 | 2531-2534 | NN | denotes | p65 |
T2612 | 2535-2537 | IN | denotes | at |
T2613 | 2538-2544 | NN | denotes | Ser276 |
T2614 | 2544-2545 | -COMMA- | denotes | , |
T2615 | 2546-2552 | NN | denotes | Ser529 |
T2616 | 2553-2555 | CC | denotes | or |
T2617 | 2556-2562 | NN | denotes | Ser536 |
T2618 | 2563-2568 | VB | denotes | plays |
T2619 | 2569-2571 | DT | denotes | an |
T2620 | 2572-2581 | JJ | denotes | important |
T2621 | 2582-2586 | NN | denotes | role |
T2622 | 2587-2589 | IN | denotes | in |
T2623 | 2590-2600 | VB | denotes | regulating |
T2624 | 2601-2616 | JJ | denotes | transcriptional |
T2625 | 2617-2625 | NN | denotes | activity |
T2626 | 2626-2628 | IN | denotes | of |
T2627 | 2629-2634 | NN | denotes | NF-κB |
T2628 | 2635-2636 | -LRB- | denotes | [ |
T2629 | 2636-2638 | CD | denotes | 17 |
T2630 | 2638-2639 | -RRB- | denotes | ] |
T2631 | 2641-2643 | IN | denotes | In |
T2632 | 2644-2656 | JJ | denotes | TNFα-treated |
T2633 | 2657-2663 | JJ | denotes | murine |
T2634 | 2664-2675 | NN | denotes | fibroblasts |
T2635 | 2675-2676 | -COMMA- | denotes | , |
T2636 | 2677-2683 | NN | denotes | Ser276 |
T2637 | 2684-2686 | IN | denotes | of |
T2638 | 2687-2692 | NN | denotes | NF-κB |
T2639 | 2693-2696 | NN | denotes | p65 |
T2640 | 2697-2699 | VB | denotes | is |
T2641 | 2700-2714 | VB | denotes | phosphorylated |
T2642 | 2715-2717 | IN | denotes | by |
T2643 | 2718-2722 | NN | denotes | MSK1 |
T2644 | 2723-2725 | TO | denotes | to |
T2645 | 2726-2733 | VB | denotes | enhance |
T2646 | 2734-2739 | NN | denotes | NF-κB |
T2647 | 2740-2755 | JJ | denotes | transcriptional |
T2648 | 2756-2764 | NN | denotes | activity |
T2649 | 2765-2766 | -LRB- | denotes | [ |
T2650 | 2766-2768 | CD | denotes | 18 |
T2651 | 2768-2769 | -RRB- | denotes | ] |
T2652 | 2771-2773 | IN | denotes | In |
T2653 | 2774-2785 | NN | denotes | macrophages |
T2654 | 2786-2793 | VB | denotes | treated |
T2655 | 2794-2798 | IN | denotes | with |
T2656 | 2799-2808 | NN | denotes | endotoxin |
T2657 | 2808-2809 | -COMMA- | denotes | , |
T2658 | 2810-2815 | NN | denotes | NF-κB |
T2659 | 2816-2829 | NN | denotes | transcription |
T2660 | 2830-2838 | NN | denotes | activity |
T2661 | 2839-2841 | VB | denotes | is |
T2662 | 2842-2852 | VB | denotes | associated |
T2663 | 2853-2857 | IN | denotes | with |
T2664 | 2858-2873 | NN | denotes | phosphorylation |
T2665 | 2874-2876 | IN | denotes | on |
T2666 | 2877-2883 | NN | denotes | Ser276 |
T2667 | 2884-2887 | CC | denotes | and |
T2668 | 2888-2894 | NN | denotes | Ser536 |
T2669 | 2895-2899 | WDT | denotes | that |
T2670 | 2900-2902 | VB | denotes | is |
T2671 | 2903-2912 | VB | denotes | regulated |
T2672 | 2913-2920 | IN | denotes | through |
T2673 | 2921-2928 | NN | denotes | protein |
T2674 | 2929-2935 | NN | denotes | kinase |
T2675 | 2936-2937 | NN | denotes | A |
T2676 | 2938-2939 | -LRB- | denotes | ( |
T2677 | 2939-2942 | NN | denotes | PKA |
T2678 | 2942-2943 | -RRB- | denotes | ) |
T2679 | 2944-2947 | CC | denotes | and |
T2680 | 2948-2952 | NN | denotes | IKKβ |
T2681 | 2953-2965 | RB | denotes | respectively |
T2682 | 2965-2966 | -LRB- | denotes | [ |
T2683 | 2966-2968 | CD | denotes | 16 |
T2684 | 2968-2969 | -RRB- | denotes | ] |
T2685 | 2969-2970 | -COMMA- | denotes | , |
T2686 | 2971-2972 | -LRB- | denotes | [ |
T2687 | 2972-2974 | CD | denotes | 19 |
T2688 | 2974-2975 | -RRB- | denotes | ] |
T2689 | 2977-2979 | IN | denotes | In |
T2690 | 2980-2985 | JJ | denotes | human |
T2691 | 2986-2987 | NN | denotes | T |
T2692 | 2988-2993 | NN | denotes | cells |
T2693 | 2993-2994 | -COMMA- | denotes | , |
T2694 | 2995-3000 | NN | denotes | NF-κB |
T2695 | 3001-3004 | NN | denotes | p65 |
T2696 | 3005-3007 | VB | denotes | is |
T2697 | 3008-3022 | RB | denotes | constitutively |
T2698 | 3023-3037 | VB | denotes | phosphorylated |
T2699 | 3038-3040 | IN | denotes | on |
T2700 | 3041-3047 | NN | denotes | Ser536 |
T2701 | 3048-3050 | TO | denotes | to |
T2702 | 3051-3061 | VB | denotes | facilitate |
T2703 | 3062-3067 | NN | denotes | NF-κB |
T2704 | 3068-3071 | NN | denotes | p65 |
T2705 | 3072-3079 | JJ | denotes | nuclear |
T2706 | 3080-3093 | NN | denotes | translocation |
T2707 | 3094-3103 | VB | denotes | following |
T2708 | 3104-3112 | JJ | denotes | cellular |
T2709 | 3113-3124 | NN | denotes | stimulation |
T2710 | 3125-3126 | -LRB- | denotes | [ |
T2711 | 3126-3128 | CD | denotes | 20 |
T2712 | 3128-3129 | -RRB- | denotes | ] |
T2713 | 3131-3143 | VB | denotes | Accumulating |
T2714 | 3144-3152 | NN | denotes | evidence |
T2715 | 3153-3160 | VB | denotes | reveals |
T2716 | 3161-3165 | IN | denotes | that |
T2717 | 3166-3171 | NN | denotes | NF-κB |
T2718 | 3172-3175 | NN | denotes | p65 |
T2719 | 3176-3191 | NN | denotes | phosphorylation |
T2720 | 3192-3194 | IN | denotes | at |
T2721 | 3195-3201 | NN | denotes | Ser276 |
T2722 | 3202-3204 | VB | denotes | is |
T2723 | 3205-3212 | JJ | denotes | crucial |
T2724 | 3213-3216 | IN | denotes | for |
T2725 | 3217-3220 | PRP-DOLLAR- | denotes | its |
T2726 | 3221-3236 | JJ | denotes | transcriptional |
T2727 | 3237-3245 | NN | denotes | activity |
T2728 | 3247-3251 | IN | denotes | Upon |
T2729 | 3252-3259 | JJ | denotes | nuclear |
T2730 | 3260-3273 | NN | denotes | translocation |
T2731 | 3273-3274 | -COMMA- | denotes | , |
T2732 | 3275-3290 | NN | denotes | phosphorylation |
T2733 | 3291-3293 | IN | denotes | of |
T2734 | 3294-3300 | NN | denotes | Ser276 |
T2735 | 3301-3303 | IN | denotes | on |
T2736 | 3304-3309 | NN | denotes | NF-κB |
T2737 | 3310-3313 | NN | denotes | p65 |
T2738 | 3314-3316 | IN | denotes | by |
T2739 | 3317-3320 | NN | denotes | PKA |
T2740 | 3321-3329 | VB | denotes | recruits |
T2741 | 3330-3333 | DT | denotes | the |
T2742 | 3334-3347 | NN | denotes | transcription |
T2743 | 3348-3360 | NN | denotes | co-activator |
T2744 | 3360-3361 | -COMMA- | denotes | , |
T2745 | 3362-3366 | NN | denotes | p300 |
T2746 | 3367-3369 | TO | denotes | to |
T2747 | 3370-3380 | VB | denotes | potentiate |
T2748 | 3381-3396 | JJ | denotes | NF-κB-regulated |
T2749 | 3397-3401 | NN | denotes | gene |
T2750 | 3402-3415 | NN | denotes | transcription |
T2751 | 3416-3417 | -LRB- | denotes | [ |
T2752 | 3417-3419 | CD | denotes | 21 |
T2753 | 3419-3420 | -RRB- | denotes | ] |
T2754 | 3422-3429 | RB | denotes | However |
T2755 | 3429-3430 | -COMMA- | denotes | , |
T2756 | 3431-3436 | JJ | denotes | other |
T2757 | 3437-3444 | NN | denotes | studies |
T2758 | 3445-3449 | VB | denotes | show |
T2759 | 3450-3454 | IN | denotes | that |
T2760 | 3455-3458 | NN | denotes | PKA |
T2761 | 3459-3467 | VB | denotes | inhibits |
T2762 | 3468-3483 | JJ | denotes | NF-κB-regulated |
T2763 | 3484-3488 | NN | denotes | gene |
T2764 | 3489-3499 | NN | denotes | expression |
T2765 | 3500-3502 | IN | denotes | by |
T2766 | 3503-3514 | VB | denotes | stabilizing |
T2767 | 3515-3519 | NNP | denotes | IκBα |
T2768 | 3520-3521 | -LRB- | denotes | [ |
T2769 | 3521-3523 | CD | denotes | 22 |
T2770 | 3523-3524 | -RRB- | denotes | ] |
T2771 | 3524-3525 | -COMMA- | denotes | , |
T2772 | 3526-3527 | -LRB- | denotes | [ |
T2773 | 3527-3529 | CD | denotes | 23 |
T2774 | 3529-3530 | -RRB- | denotes | ] |
T2775 | 3532-3545 | RB | denotes | Interestingly |
T2776 | 3545-3546 | -COMMA- | denotes | , |
T2777 | 3547-3550 | DT | denotes | the |
T2778 | 3551-3567 | NN | denotes | serine/threonine |
T2779 | 3568-3574 | NN | denotes | kinase |
T2780 | 3575-3580 | NN | denotes | Pim-1 |
T2781 | 3581-3589 | RB | denotes | directly |
T2782 | 3590-3604 | VB | denotes | phosphorylates |
T2783 | 3605-3610 | NN | denotes | NF-κB |
T2784 | 3611-3614 | NN | denotes | p65 |
T2785 | 3615-3617 | IN | denotes | at |
T2786 | 3618-3624 | NN | denotes | Ser276 |
T2787 | 3625-3627 | IN | denotes | by |
T2788 | 3628-3639 | VB | denotes | stabilizing |
T2789 | 3640-3642 | TO | denotes | to |
T2790 | 3643-3650 | VB | denotes | prevent |
T2791 | 3651-3671 | JJ | denotes | ubiquitin-proteasome |
T2792 | 3672-3683 | NN | denotes | degradation |
T2793 | 3684-3685 | -LRB- | denotes | [ |
T2794 | 3685-3687 | CD | denotes | 24 |
T2795 | 3687-3688 | -RRB- | denotes | ] |
T2796 | 3690-3697 | JJ | denotes | Several |
T2797 | 3698-3703 | JJ | denotes | other |
T2798 | 3704-3719 | NN | denotes | phosphorylation |
T2799 | 3720-3725 | NN | denotes | sites |
T2800 | 3726-3729 | VB | denotes | are |
T2801 | 3730-3734 | RB | denotes | also |
T2802 | 3735-3744 | VB | denotes | described |
T2803 | 3745-3747 | TO | denotes | to |
T2804 | 3748-3755 | VB | denotes | enhance |
T2805 | 3756-3761 | NN | denotes | NF-κB |
T2806 | 3762-3766 | NN | denotes | gene |
T2807 | 3767-3782 | NN | denotes | transactivation |
T2808 | 3783-3784 | -LRB- | denotes | [ |
T2809 | 3784-3786 | CD | denotes | 25 |
T2810 | 3786-3787 | -RRB- | denotes | ] |
T2811 | 3789-3793 | RB | denotes | Here |
T2812 | 3793-3794 | -COMMA- | denotes | , |
T2813 | 3795-3797 | PRP | denotes | we |
T2814 | 3798-3809 | VB | denotes | investigate |
T2815 | 3810-3813 | DT | denotes | the |
T2816 | 3814-3818 | NN | denotes | role |
T2817 | 3819-3821 | IN | denotes | of |
T2818 | 3822-3829 | NN | denotes | protein |
T2819 | 3830-3836 | NN | denotes | kinase |
T2820 | 3837-3838 | NN | denotes | C |
T2821 | 3839-3840 | -LRB- | denotes | ( |
T2822 | 3840-3843 | NN | denotes | PKC |
T2823 | 3843-3844 | -RRB- | denotes | ) |
T2824 | 3845-3847 | IN | denotes | in |
T2825 | 3848-3864 | JJ | denotes | M-CSF-stimulated |
T2826 | 3865-3870 | NN | denotes | NF-κB |
T2827 | 3871-3881 | NN | denotes | activation |
T2828 | 3883-3886 | NN | denotes | PKC |
T2829 | 3887-3895 | NN | denotes | proteins |
T2830 | 3896-3899 | VB | denotes | are |
T2831 | 3900-3915 | JJ | denotes | multifunctional |
T2832 | 3916-3923 | NN | denotes | kinases |
T2833 | 3924-3928 | WDT | denotes | that |
T2834 | 3929-3935 | VB | denotes | differ |
T2835 | 3936-3938 | IN | denotes | in |
T2836 | 3939-3948 | NN | denotes | structure |
T2837 | 3948-3949 | -COMMA- | denotes | , |
T2838 | 3950-3958 | NN | denotes | function |
T2839 | 3959-3962 | CC | denotes | and |
T2840 | 3963-3972 | NN | denotes | co-factor |
T2841 | 3973-3984 | NN | denotes | requirement |
T2842 | 3985-3986 | -LRB- | denotes | [ |
T2843 | 3986-3988 | CD | denotes | 26 |
T2844 | 3988-3989 | -RRB- | denotes | ] |
T2845 | 3991-3995 | NN | denotes | PKCs |
T2846 | 3996-3999 | VB | denotes | are |
T2847 | 4000-4008 | VB | denotes | involved |
T2848 | 4009-4011 | IN | denotes | in |
T2849 | 4012-4019 | JJ | denotes | diverse |
T2850 | 4020-4024 | NN | denotes | cell |
T2851 | 4025-4034 | NN | denotes | responses |
T2852 | 4034-4035 | -COMMA- | denotes | , |
T2853 | 4036-4045 | VB | denotes | including |
T2854 | 4046-4050 | NN | denotes | cell |
T2855 | 4051-4057 | NN | denotes | growth |
T2856 | 4057-4058 | -COMMA- | denotes | , |
T2857 | 4059-4067 | NN | denotes | survival |
T2858 | 4067-4068 | -COMMA- | denotes | , |
T2859 | 4069-4084 | NN | denotes | differentiation |
T2860 | 4085-4088 | CC | denotes | and |
T2861 | 4089-4100 | NN | denotes | development |
T2862 | 4101-4102 | -LRB- | denotes | [ |
T2863 | 4102-4104 | CD | denotes | 27 |
T2864 | 4104-4105 | -RRB- | denotes | ] |
T2865 | 4107-4110 | DT | denotes | The |
T2866 | 4111-4113 | CD | denotes | 12 |
T2867 | 4114-4121 | RB | denotes | closely |
T2868 | 4122-4129 | JJ | denotes | related |
T2869 | 4130-4137 | NN | denotes | enzymes |
T2870 | 4138-4140 | IN | denotes | of |
T2871 | 4141-4144 | DT | denotes | the |
T2872 | 4145-4148 | NN | denotes | PKC |
T2873 | 4149-4155 | NN | denotes | family |
T2874 | 4156-4159 | VB | denotes | are |
T2875 | 4160-4167 | VB | denotes | divided |
T2876 | 4168-4172 | IN | denotes | into |
T2877 | 4173-4178 | CD | denotes | three |
T2878 | 4179-4186 | NN | denotes | classes |
T2879 | 4186-4187 | -COLON- | denotes | : |
T2880 | 4188-4200 | JJ | denotes | conventional |
T2881 | 4201-4202 | -LRB- | denotes | ( |
T2882 | 4202-4207 | NN | denotes | cPKCs |
T2883 | 4207-4208 | -COLON- | denotes | : |
T2884 | 4209-4210 | LS | denotes | α |
T2885 | 4211-4213 | NNP | denotes | βI |
T2886 | 4214-4217 | NNP | denotes | βII |
T2887 | 4218-4221 | CC | denotes | and |
T2888 | 4222-4223 | VB | denotes | γ |
T2889 | 4224-4231 | VB | denotes | require |
T2890 | 4232-4236 | NN | denotes | Ca2+ |
T2891 | 4237-4240 | CC | denotes | and |
T2892 | 4241-4255 | NN | denotes | diacylglycerol |
T2893 | 4256-4257 | -LRB- | denotes | ( |
T2894 | 4257-4260 | NN | denotes | DAG |
T2895 | 4260-4261 | -RRB- | denotes | ) |
T2896 | 4261-4262 | -COLON- | denotes | ; |
T2897 | 4263-4268 | JJ | denotes | novel |
T2898 | 4269-4270 | -LRB- | denotes | ( |
T2899 | 4270-4275 | NN | denotes | nPKCs |
T2900 | 4275-4276 | -COLON- | denotes | : |
T2901 | 4277-4278 | LS | denotes | δ |
T2902 | 4278-4279 | -COMMA- | denotes | , |
T2903 | 4280-4281 | UH | denotes | ε |
T2904 | 4281-4282 | -COMMA- | denotes | , |
T2905 | 4283-4284 | UH | denotes | η |
T2906 | 4284-4285 | -COMMA- | denotes | , |
T2907 | 4286-4287 | NN | denotes | θ |
T2908 | 4288-4291 | CC | denotes | and |
T2909 | 4292-4293 | LS | denotes | μ |
T2910 | 4293-4294 | -RRB- | denotes | ) |
T2911 | 4295-4302 | VB | denotes | require |
T2912 | 4303-4306 | NN | denotes | DAG |
T2913 | 4306-4307 | -COLON- | denotes | ; |
T2914 | 4308-4311 | CC | denotes | and |
T2915 | 4312-4320 | JJ | denotes | atypical |
T2916 | 4321-4322 | -LRB- | denotes | ( |
T2917 | 4322-4327 | NN | denotes | aPKCs |
T2918 | 4327-4328 | -COLON- | denotes | : |
T2919 | 4329-4330 | LS | denotes | ξ |
T2920 | 4330-4331 | -COMMA- | denotes | , |
T2921 | 4332-4333 | VB | denotes | ι |
T2922 | 4334-4337 | CC | denotes | and |
T2923 | 4338-4339 | LS | denotes | λ |
T2924 | 4339-4340 | -RRB- | denotes | ) |
T2925 | 4341-4348 | VB | denotes | require |
T2926 | 4349-4356 | CC | denotes | neither |
T2927 | 4357-4361 | NN | denotes | Ca2+ |
T2928 | 4362-4365 | CC | denotes | nor |
T2929 | 4366-4369 | NN | denotes | DAG |
T2930 | 4371-4380 | NN | denotes | Monocytes |
T2931 | 4381-4384 | CC | denotes | and |
T2932 | 4385-4396 | NN | denotes | macrophages |
T2933 | 4397-4410 | RB | denotes | predominantly |
T2934 | 4411-4418 | VB | denotes | express |
T2935 | 4419-4431 | JJ | denotes | conventional |
T2936 | 4432-4435 | NN | denotes | PKC |
T2937 | 4436-4444 | NN | denotes | isoforms |
T2938 | 4445-4446 | -LRB- | denotes | ( |
T2939 | 4446-4450 | NN | denotes | PKCα |
T2940 | 4451-4456 | NN | denotes | PKCβI |
T2941 | 4457-4460 | CC | denotes | and |
T2942 | 4461-4467 | NN | denotes | PKCβII |
T2943 | 4467-4468 | -RRB- | denotes | ) |
T2944 | 4469-4472 | CC | denotes | and |
T2945 | 4473-4478 | JJ | denotes | novel |
T2946 | 4479-4483 | NN | denotes | PKCs |
T2947 | 4484-4485 | -LRB- | denotes | ( |
T2948 | 4485-4489 | NN | denotes | PKCδ |
T2949 | 4490-4493 | CC | denotes | and |
T2950 | 4494-4498 | NN | denotes | PKCε |
T2951 | 4498-4499 | -RRB- | denotes | ) |
T2952 | 4501-4513 | JJ | denotes | Conventional |
T2953 | 4514-4518 | NN | denotes | PKCs |
T2954 | 4519-4527 | VB | denotes | regulate |
T2955 | 4528-4543 | NN | denotes | differentiation |
T2956 | 4544-4546 | IN | denotes | of |
T2957 | 4547-4550 | DT | denotes | the |
T2958 | 4551-4556 | JJ | denotes | human |
T2959 | 4557-4570 | JJ | denotes | promyelocytic |
T2960 | 4571-4579 | NN | denotes | leukemia |
T2961 | 4580-4584 | NN | denotes | cell |
T2962 | 4585-4589 | NN | denotes | line |
T2963 | 4590-4594 | NN | denotes | HL60 |
T2964 | 4595-4597 | TO | denotes | to |
T2965 | 4598-4609 | NN | denotes | macrophages |
T2966 | 4610-4611 | -LRB- | denotes | [ |
T2967 | 4611-4613 | CD | denotes | 28 |
T2968 | 4613-4614 | -RRB- | denotes | ] |
T2969 | 4616-4620 | NN | denotes | PKCα |
T2970 | 4621-4628 | VB | denotes | induces |
T2971 | 4629-4634 | NN | denotes | IL-1α |
T2972 | 4634-4635 | -COMMA- | denotes | , |
T2973 | 4636-4640 | NN | denotes | iNOS |
T2974 | 4641-4644 | CC | denotes | and |
T2975 | 4645-4649 | NN | denotes | TNFα |
T2976 | 4650-4654 | NN | denotes | mRNA |
T2977 | 4655-4665 | NN | denotes | production |
T2978 | 4666-4671 | IN | denotes | after |
T2979 | 4672-4690 | NN | denotes | lipopolysaccharide |
T2980 | 4691-4692 | -LRB- | denotes | ( |
T2981 | 4692-4695 | NN | denotes | LPS |
T2982 | 4695-4696 | -RRB- | denotes | ) |
T2983 | 4697-4705 | NN | denotes | exposure |
T2984 | 4706-4707 | -LRB- | denotes | [ |
T2985 | 4707-4709 | CD | denotes | 29 |
T2986 | 4709-4710 | -RRB- | denotes | ] |
T2987 | 4712-4714 | IN | denotes | In |
T2988 | 4715-4723 | NN | denotes | addition |
T2989 | 4723-4724 | -COMMA- | denotes | , |
T2990 | 4725-4737 | VB | denotes | accumulating |
T2991 | 4738-4746 | NN | denotes | evidence |
T2992 | 4747-4755 | VB | denotes | suggests |
T2993 | 4756-4760 | IN | denotes | that |
T2994 | 4761-4773 | JJ | denotes | conventional |
T2995 | 4774-4778 | NN | denotes | PKCs |
T2996 | 4779-4783 | IN | denotes | like |
T2997 | 4784-4788 | NN | denotes | PKCα |
T2998 | 4789-4793 | VB | denotes | have |
T2999 | 4794-4808 | JJ | denotes | anti-apoptotic |
T3000 | 4809-4818 | NN | denotes | functions |
T3001 | 4820-4823 | IN | denotes | For |
T3002 | 4824-4831 | NN | denotes | example |
T3003 | 4831-4832 | -COMMA- | denotes | , |
T3004 | 4833-4837 | NN | denotes | PKCα |
T3005 | 4838-4840 | VB | denotes | is |
T3006 | 4841-4854 | VB | denotes | overexpressed |
T3007 | 4855-4857 | IN | denotes | in |
T3008 | 4858-4859 | DT | denotes | a |
T3009 | 4860-4867 | NN | denotes | variety |
T3010 | 4868-4870 | IN | denotes | of |
T3011 | 4871-4876 | NN | denotes | tumor |
T3012 | 4877-4882 | NN | denotes | cells |
T3013 | 4883-4892 | VB | denotes | including |
T3014 | 4893-4900 | NN | denotes | gliomas |
T3015 | 4900-4901 | -COMMA- | denotes | , |
T3016 | 4902-4907 | NN | denotes | liver |
T3017 | 4907-4908 | -COMMA- | denotes | , |
T3018 | 4909-4912 | CC | denotes | and |
T3019 | 4913-4917 | NN | denotes | lung |
T3020 | 4918-4919 | -LRB- | denotes | [ |
T3021 | 4919-4921 | CD | denotes | 30 |
T3022 | 4921-4922 | -RRB- | denotes | ] |
T3023 | 4922-4923 | -COMMA- | denotes | , |
T3024 | 4924-4925 | -LRB- | denotes | [ |
T3025 | 4925-4927 | CD | denotes | 31 |
T3026 | 4927-4928 | -RRB- | denotes | ] |
T3027 | 4930-4932 | IN | denotes | In |
T3028 | 4933-4943 | JJ | denotes | epithelial |
T3029 | 4944-4949 | NN | denotes | cells |
T3030 | 4949-4950 | -COMMA- | denotes | , |
T3031 | 4951-4961 | NN | denotes | inhibition |
T3032 | 4962-4964 | IN | denotes | of |
T3033 | 4965-4969 | NN | denotes | PKCα |
T3034 | 4970-4977 | VB | denotes | induces |
T3035 | 4978-4992 | JJ | denotes | PKCδ-dependent |
T3036 | 4993-5002 | NN | denotes | apoptosis |
T3037 | 5003-5004 | -LRB- | denotes | [ |
T3038 | 5004-5006 | CD | denotes | 31 |
T3039 | 5006-5007 | -RRB- | denotes | ] |
T3040 | 5009-5022 | RB | denotes | Interestingly |
T3041 | 5022-5023 | -COMMA- | denotes | , |
T3042 | 5024-5026 | IN | denotes | in |
T3043 | 5027-5032 | JJ | denotes | human |
T3044 | 5033-5042 | NN | denotes | monocytes |
T3045 | 5043-5046 | CC | denotes | and |
T3046 | 5047-5059 | JJ | denotes | premonocytic |
T3047 | 5060-5065 | NN | denotes | THP-1 |
T3048 | 5066-5074 | NN | denotes | leukemia |
T3049 | 5075-5080 | NN | denotes | cells |
T3050 | 5080-5081 | -COMMA- | denotes | , |
T3051 | 5082-5087 | JJ | denotes | novel |
T3052 | 5088-5092 | NN | denotes | PKCs |
T3053 | 5093-5097 | IN | denotes | like |
T3054 | 5098-5102 | NN | denotes | PKCδ |
T3055 | 5103-5107 | VB | denotes | have |
T3056 | 5108-5111 | DT | denotes | the |
T3057 | 5112-5120 | JJ | denotes | opposite |
T3058 | 5121-5127 | NN | denotes | effect |
T3059 | 5128-5130 | IN | denotes | on |
T3060 | 5131-5135 | NN | denotes | cell |
T3061 | 5136-5144 | NN | denotes | survival |
T3062 | 5144-5145 | -COMMA- | denotes | , |
T3063 | 5146-5150 | NNP | denotes | Voss |
T3064 | 5151-5153 | FW | denotes | et |
T3065 | 5154-5156 | FW | denotes | al |
T3066 | 5157-5163 | VB | denotes | showed |
T3067 | 5164-5168 | IN | denotes | that |
T3068 | 5169-5173 | NN | denotes | PKCδ |
T3069 | 5174-5182 | RB | denotes | directly |
T3070 | 5183-5197 | VB | denotes | phosphorylates |
T3071 | 5198-5207 | NN | denotes | caspase-3 |
T3072 | 5208-5211 | CC | denotes | and |
T3073 | 5212-5220 | VB | denotes | promotes |
T3074 | 5221-5238 | JJ | denotes | etoposide-induced |
T3075 | 5239-5248 | NN | denotes | apoptosis |
T3076 | 5249-5250 | -LRB- | denotes | [ |
T3077 | 5250-5252 | CD | denotes | 32 |
T3078 | 5252-5253 | -RRB- | denotes | ] |
T3079 | 5255-5263 | RB | denotes | Moreover |
T3080 | 5263-5264 | -COMMA- | denotes | , |
T3081 | 5265-5273 | JJ | denotes | knockout |
T3082 | 5274-5279 | NN | denotes | mouse |
T3083 | 5280-5287 | NN | denotes | studies |
T3084 | 5288-5295 | VB | denotes | suggest |
T3085 | 5296-5300 | IN | denotes | that |
T3086 | 5301-5308 | DT | denotes | another |
T3087 | 5309-5314 | JJ | denotes | novel |
T3088 | 5315-5318 | NN | denotes | PKC |
T3089 | 5318-5319 | -COMMA- | denotes | , |
T3090 | 5320-5324 | NN | denotes | PKCε |
T3091 | 5325-5327 | VB | denotes | is |
T3092 | 5328-5338 | RB | denotes | critically |
T3093 | 5339-5347 | VB | denotes | involved |
T3094 | 5348-5350 | IN | denotes | in |
T3095 | 5351-5356 | JJ | denotes | early |
T3096 | 5357-5369 | JJ | denotes | LPS-mediated |
T3097 | 5370-5379 | NN | denotes | signaling |
T3098 | 5380-5382 | IN | denotes | in |
T3099 | 5383-5392 | VB | denotes | activated |
T3100 | 5393-5404 | NN | denotes | macrophages |
T3101 | 5405-5406 | -LRB- | denotes | [ |
T3102 | 5406-5408 | CD | denotes | 33 |
T3103 | 5408-5409 | -RRB- | denotes | ] |
T3104 | 5411-5421 | RB | denotes | Previously |
T3105 | 5421-5422 | -COMMA- | denotes | , |
T3106 | 5423-5425 | PRP | denotes | we |
T3107 | 5426-5434 | VB | denotes | reported |
T3108 | 5435-5439 | IN | denotes | that |
T3109 | 5440-5445 | NN | denotes | M-CSF |
T3110 | 5446-5454 | VB | denotes | promotes |
T3111 | 5455-5463 | NN | denotes | monocyte |
T3112 | 5464-5472 | NN | denotes | survival |
T3113 | 5473-5480 | IN | denotes | through |
T3114 | 5481-5484 | DT | denotes | the |
T3115 | 5485-5495 | NN | denotes | activation |
T3116 | 5496-5498 | IN | denotes | of |
T3117 | 5499-5502 | DT | denotes | the |
T3118 | 5503-5512 | NN | denotes | PI3-K/AKT |
T3119 | 5513-5520 | NN | denotes | pathway |
T3120 | 5521-5522 | -LRB- | denotes | [ |
T3121 | 5522-5523 | CD | denotes | 3 |
T3122 | 5523-5524 | -RRB- | denotes | ] |
T3123 | 5526-5528 | IN | denotes | In |
T3124 | 5529-5537 | NN | denotes | addition |
T3125 | 5538-5540 | TO | denotes | to |
T3126 | 5541-5544 | NN | denotes | AKT |
T3127 | 5545-5555 | NN | denotes | activation |
T3128 | 5555-5556 | -COMMA- | denotes | , |
T3129 | 5557-5562 | NN | denotes | M-CSF |
T3130 | 5563-5573 | VB | denotes | stimulates |
T3131 | 5574-5577 | NN | denotes | PKC |
T3132 | 5578-5580 | IN | denotes | in |
T3133 | 5581-5586 | JJ | denotes | human |
T3134 | 5587-5596 | NN | denotes | monocytes |
T3135 | 5597-5600 | CC | denotes | and |
T3136 | 5601-5610 | VB | denotes | increases |
T3137 | 5611-5616 | NN | denotes | NF-κB |
T3138 | 5617-5620 | NN | denotes | DNA |
T3139 | 5621-5628 | NN | denotes | binding |
T3140 | 5629-5630 | -LRB- | denotes | [ |
T3141 | 5630-5632 | CD | denotes | 34 |
T3142 | 5632-5633 | -RRB- | denotes | ] |
T3143 | 5635-5642 | RB | denotes | However |
T3144 | 5642-5643 | -COMMA- | denotes | , |
T3145 | 5644-5651 | IN | denotes | whether |
T3146 | 5652-5655 | NN | denotes | PKC |
T3147 | 5656-5662 | CC | denotes | and/or |
T3148 | 5663-5668 | NN | denotes | NF-κB |
T3149 | 5669-5679 | NN | denotes | activation |
T3150 | 5680-5682 | VB | denotes | is |
T3151 | 5683-5691 | JJ | denotes | critical |
T3152 | 5692-5694 | IN | denotes | in |
T3153 | 5695-5711 | JJ | denotes | M-CSF-stimulated |
T3154 | 5712-5723 | JJ | denotes | mononuclear |
T3155 | 5724-5733 | NN | denotes | phagocyte |
T3156 | 5734-5742 | NN | denotes | survival |
T3157 | 5743-5749 | CC | denotes | and/or |
T3158 | 5750-5765 | NN | denotes | differentiation |
T3159 | 5766-5768 | VB | denotes | is |
T3160 | 5769-5776 | JJ | denotes | unclear |
T3161 | 5778-5780 | IN | denotes | In |
T3162 | 5781-5786 | JJ | denotes | other |
T3163 | 5787-5792 | NN | denotes | cells |
T3164 | 5792-5793 | -COMMA- | denotes | , |
T3165 | 5794-5797 | NN | denotes | PKC |
T3166 | 5798-5803 | VB | denotes | plays |
T3167 | 5804-5806 | DT | denotes | an |
T3168 | 5807-5816 | JJ | denotes | important |
T3169 | 5817-5821 | NN | denotes | role |
T3170 | 5822-5824 | IN | denotes | in |
T3171 | 5825-5830 | NN | denotes | NF-κB |
T3172 | 5831-5841 | NN | denotes | activation |
T3173 | 5842-5845 | CC | denotes | and |
T3174 | 5846-5850 | NN | denotes | cell |
T3175 | 5851-5859 | NN | denotes | survival |
T3176 | 5860-5861 | -LRB- | denotes | [ |
T3177 | 5861-5863 | CD | denotes | 35 |
T3178 | 5863-5864 | -RRB- | denotes | ] |
T3179 | 5864-5865 | -COMMA- | denotes | , |
T3180 | 5866-5873 | RB | denotes | however |
T3181 | 5874-5877 | DT | denotes | the |
T3182 | 5878-5886 | JJ | denotes | specific |
T3183 | 5887-5897 | NN | denotes | mechanisms |
T3184 | 5898-5900 | IN | denotes | of |
T3185 | 5901-5905 | DT | denotes | this |
T3186 | 5906-5916 | NN | denotes | activation |
T3187 | 5917-5920 | CC | denotes | and |
T3188 | 5921-5924 | DT | denotes | the |
T3189 | 5925-5935 | JJ | denotes | biological |
T3190 | 5936-5943 | NN | denotes | effects |
T3191 | 5944-5946 | IN | denotes | on |
T3192 | 5947-5955 | JJ | denotes | cellular |
T3193 | 5956-5965 | NN | denotes | phenotype |
T3194 | 5966-5969 | VB | denotes | are |
T3195 | 5970-5973 | RB | denotes | not |
T3196 | 5974-5979 | VB | denotes | known |
T3197 | 5981-5990 | RB | denotes | Therefore |
T3198 | 5990-5991 | -COMMA- | denotes | , |
T3199 | 5992-5994 | PRP | denotes | we |
T3200 | 5995-6002 | VB | denotes | focused |
T3201 | 6003-6005 | IN | denotes | at |
T3202 | 6006-6019 | VB | denotes | understanding |
T3203 | 6020-6023 | DT | denotes | the |
T3204 | 6024-6028 | NN | denotes | role |
T3205 | 6029-6031 | IN | denotes | of |
T3206 | 6032-6035 | NN | denotes | PKC |
T3207 | 6036-6038 | IN | denotes | in |
T3208 | 6039-6042 | DT | denotes | the |
T3209 | 6043-6053 | NN | denotes | regulation |
T3210 | 6054-6056 | IN | denotes | of |
T3211 | 6057-6062 | NN | denotes | NF-κB |
T3212 | 6063-6073 | NN | denotes | activation |
T3213 | 6074-6077 | CC | denotes | and |
T3214 | 6078-6091 | JJ | denotes | M-CSF-induced |
T3215 | 6092-6100 | NN | denotes | monocyte |
T3216 | 6101-6109 | NN | denotes | survival |
T3217 | 6111-6115 | RB | denotes | Here |
T3218 | 6116-6118 | PRP | denotes | we |
T3219 | 6119-6131 | VB | denotes | demonstrates |
T3220 | 6132-6136 | IN | denotes | that |
T3221 | 6137-6142 | NN | denotes | M-CSF |
T3222 | 6143-6154 | VB | denotes | upregulated |
T3223 | 6155-6158 | DT | denotes | the |
T3224 | 6159-6164 | NN | denotes | NF-κB |
T3225 | 6165-6178 | NN | denotes | transcription |
T3226 | 6179-6182 | CC | denotes | and |
T3227 | 6183-6187 | NN | denotes | cell |
T3228 | 6188-6196 | NN | denotes | survival |
T3229 | 6197-6199 | IN | denotes | in |
T3230 | 6200-6205 | JJ | denotes | human |
T3231 | 6206-6209 | CC | denotes | and |
T3232 | 6210-6215 | NN | denotes | mouse |
T3233 | 6216-6227 | NN | denotes | macrophages |
T3234 | 6229-6233 | DT | denotes | This |
T3235 | 6234-6242 | NN | denotes | activity |
T3236 | 6243-6246 | VB | denotes | was |
T3237 | 6247-6254 | VB | denotes | reduced |
T3238 | 6255-6257 | IN | denotes | by |
T3239 | 6258-6261 | DT | denotes | the |
T3240 | 6262-6274 | JJ | denotes | conventional |
T3241 | 6274-6275 | -COMMA- | denotes | , |
T3242 | 6276-6279 | CC | denotes | but |
T3243 | 6280-6283 | RB | denotes | not |
T3244 | 6284-6289 | JJ | denotes | novel |
T3245 | 6289-6290 | -COMMA- | denotes | , |
T3246 | 6291-6294 | NN | denotes | PKC |
T3247 | 6295-6305 | NN | denotes | inhibitors |
T3248 | 6305-6306 | -COMMA- | denotes | , |
T3249 | 6307-6315 | JJ | denotes | dominant |
T3250 | 6316-6324 | JJ | denotes | negative |
T3251 | 6325-6329 | NN | denotes | PKCα |
T3252 | 6330-6340 | NN | denotes | constructs |
T3253 | 6341-6343 | CC | denotes | or |
T3254 | 6344-6348 | NN | denotes | PKCα |
T3255 | 6349-6354 | NN | denotes | siRNA |
T3256 | 6356-6368 | JJ | denotes | Conventional |
T3257 | 6369-6372 | NN | denotes | PKC |
T3258 | 6373-6382 | VB | denotes | regulated |
T3259 | 6383-6398 | JJ | denotes | NF-κB-regulated |
T3260 | 6399-6403 | NN | denotes | gene |
T3261 | 6404-6414 | NN | denotes | expression |
T3262 | 6415-6418 | CC | denotes | and |
T3263 | 6419-6434 | NN | denotes | phosphorylation |
T3264 | 6435-6437 | IN | denotes | of |
T3265 | 6438-6444 | NN | denotes | Ser276 |
T3266 | 6445-6447 | IN | denotes | of |
T3267 | 6448-6453 | NN | denotes | NF-κB |
T3268 | 6454-6457 | NN | denotes | p65 |
T3269 | 6458-6466 | VB | denotes | occurred |
T3270 | 6467-6469 | IN | denotes | in |
T3271 | 6470-6472 | DT | denotes | an |
T3272 | 6473-6488 | JJ | denotes | M-CSF-dependent |
T3273 | 6489-6496 | NN | denotes | fashion |
T3274 | 6497-6508 | VB | denotes | correlating |
T3275 | 6509-6513 | IN | denotes | with |
T3276 | 6514-6517 | PRP-DOLLAR- | denotes | its |
T3277 | 6518-6525 | JJ | denotes | maximal |
T3278 | 6526-6541 | JJ | denotes | transcriptional |
T3279 | 6542-6550 | NN | denotes | activity |
T3280 | 6552-6563 | RB | denotes | Furthermore |
T3281 | 6563-6564 | -COMMA- | denotes | , |
T3282 | 6565-6579 | JJ | denotes | PKCα-regulated |
T3283 | 6580-6595 | NN | denotes | phosphorylation |
T3284 | 6596-6598 | IN | denotes | of |
T3285 | 6599-6605 | NN | denotes | Ser276 |
T3286 | 6606-6608 | IN | denotes | of |
T3287 | 6609-6614 | NN | denotes | NF-κB |
T3288 | 6615-6618 | NN | denotes | p65 |
T3289 | 6619-6624 | VB | denotes | plays |
T3290 | 6625-6627 | DT | denotes | an |
T3291 | 6628-6637 | JJ | denotes | important |
T3292 | 6638-6642 | NN | denotes | role |
T3293 | 6643-6645 | IN | denotes | in |
T3294 | 6646-6656 | VB | denotes | regulating |
T3295 | 6657-6660 | PRP-DOLLAR- | denotes | its |
T3296 | 6661-6669 | NN | denotes | activity |
T3297 | 6670-6672 | IN | denotes | in |
T3298 | 6673-6684 | JJ | denotes | mononuclear |
T3299 | 6685-6695 | NN | denotes | phagocytes |
T3300 | 6696-6699 | CC | denotes | and |
T3301 | 6700-6706 | JJ | denotes | murine |
T3302 | 6707-6716 | JJ | denotes | embryonic |
T3303 | 6717-6728 | NN | denotes | fibroblasts |
T15744 | 530-539 | JJ | denotes | important |
T15745 | 540-542 | IN | denotes | in |
R1754 | T2187 | T2188 | arg1Of | Monocytes,are |
R1755 | T2187 | T2189 | arg2Of | Monocytes,produced |
R1756 | T2187 | T2195 | arg1Of | Monocytes,circulate |
R1757 | T2189 | T2188 | arg2Of | produced,are |
R1758 | T2189 | T2190 | arg1Of | produced,in |
R1759 | T2189 | T2194 | arg1Of | produced,and |
R1762 | T2193 | T2190 | arg2Of | marrow,in |
R1763 | T2193 | T2191 | arg1Of | marrow,the |
R1764 | T2193 | T2192 | arg1Of | marrow,bone |
R1765 | T2195 | T2194 | arg2Of | circulate,and |
R1766 | T2195 | T2196 | arg1Of | circulate,in |
R1768 | T2197 | T2196 | arg2Of | blood,in |
R1769 | T2197 | T2198 | arg1Of | blood,for |
R1771 | T2200 | T2198 | arg2Of | hours,for |
R1772 | T2200 | T2199 | arg1Of | hours,24–48 |
R1773 | T2200 | T2201 | arg1Of | hours,[ |
R1774 | T2202 | T2201 | arg2Of | 1,[ |
R1775 | T2203 | T2201 | arg3Of | ],[ |
R1777 | T2206 | T2204 | arg2Of | absence,In |
R1778 | T2206 | T2205 | arg1Of | absence,the |
R1779 | T2206 | T2207 | arg1Of | absence,of |
R1781 | T2208 | T2207 | arg2Of | serum,of |
R1783 | T2210 | T2211 | arg1Of | monocytes,die |
R1784 | T2211 | T2204 | arg1Of | die,In |
R1785 | T2211 | T2209 | arg1Of | die,"," |
R1786 | T2211 | T2212 | arg1Of | die,via |
R1787 | T2211 | T2214 | arg1Of | die,[ |
R1788 | T2211 | T2217 | arg1Of | die,"," |
R1789 | T2211 | T2218 | arg1Of | die,[ |
R1790 | T2213 | T2212 | arg2Of | apoptosis,via |
R1792 | T2215 | T2214 | arg2Of | 1,[ |
R1793 | T2216 | T2214 | arg3Of | ],[ |
R1796 | T2219 | T2218 | arg2Of | 2,[ |
R1797 | T2220 | T2218 | arg3Of | ],[ |
R1799 | T2223 | T2221 | arg1Of | factor,Macrophage |
R1800 | T2223 | T2222 | arg1Of | factor,colony-stimulating |
R1801 | T2223 | T2224 | arg1Of | factor,( |
R1802 | T2223 | T2227 | arg1Of | factor,stimulates |
R1803 | T2225 | T2224 | arg2Of | M-CSF,( |
R1805 | T2226 | T2224 | arg3Of | ),( |
R1807 | T2230 | T2228 | arg1Of | survival,mononuclear |
R1808 | T2230 | T2229 | arg1Of | survival,phagocyte |
R1809 | T2230 | T2231 | arg1Of | survival,and |
R1811 | T2231 | T2227 | arg2Of | and,stimulates |
R1812 | T2232 | T2231 | arg2Of | differentiation,and |
R1813 | T2232 | T2233 | arg1Of | differentiation,[ |
R1814 | T2234 | T2233 | arg2Of | 3,[ |
R1816 | T2235 | T2233 | arg3Of | ],[ |
R1819 | T2240 | T2238 | arg1Of | survival,M-CSF-mediated |
R1820 | T2240 | T2239 | arg1Of | survival,cell |
R1821 | T2240 | T2241 | arg1Of | survival,and |
R1822 | T2241 | T2243 | arg1Of | and,is |
R1823 | T2241 | T2244 | arg2Of | and,associated |
R1825 | T2242 | T2241 | arg2Of | activation,and |
R1828 | T2244 | T2236 | arg1Of | associated,Importantly |
R1829 | T2244 | T2237 | arg1Of | associated,"," |
R1830 | T2244 | T2243 | arg2Of | associated,is |
R1831 | T2244 | T2245 | arg1Of | associated,with |
R1832 | T2244 | T2265 | arg1Of | associated,"," |
R1833 | T2244 | T2266 | arg1Of | associated,[ |
R1834 | T2244 | T2269 | arg1Of | associated,"," |
R1835 | T2244 | T2270 | arg1Of | associated,[ |
R1837 | T2247 | T2245 | arg2Of | variety,with |
R1838 | T2247 | T2246 | arg1Of | variety,a |
R1839 | T2247 | T2248 | arg1Of | variety,of |
R1841 | T2250 | T2248 | arg2Of | diseases,of |
R1842 | T2250 | T2249 | arg1Of | diseases,human |
R1843 | T2250 | T2251 | arg1Of | diseases,"," |
R1844 | T2250 | T2252 | arg1Of | diseases,including |
R1846 | T2253 | T2254 | arg1Of | atherosclerosis,"," |
R1847 | T2254 | T2258 | arg1Of | ",",and |
R1849 | T2257 | T2254 | arg2Of | sclerosis,"," |
R1850 | T2257 | T2255 | arg1Of | sclerosis,transplant |
R1851 | T2257 | T2256 | arg1Of | sclerosis,vascular |
R1852 | T2258 | T2252 | arg2Of | and,including |
R1854 | T2261 | T2258 | arg2Of | metastasis,and |
R1855 | T2261 | T2259 | arg1Of | metastasis,breast |
R1856 | T2261 | T2260 | arg1Of | metastasis,cancer |
R1857 | T2261 | T2262 | arg1Of | metastasis,[ |
R1858 | T2263 | T2262 | arg2Of | 4,[ |
R1860 | T2264 | T2262 | arg3Of | ],[ |
R1862 | T2267 | T2266 | arg2Of | 5,[ |
R1863 | T2268 | T2266 | arg3Of | ],[ |
R1866 | T2271 | T2270 | arg2Of | 6,[ |
R1867 | T2272 | T2270 | arg3Of | ],[ |
R1869 | T2273 | T2275 | arg1Of | We,identified |
R1870 | T2275 | T2274 | arg1Of | identified,previously |
R1872 | T2278 | T2277 | arg1Of | activation,NF-κB |
R1873 | T2278 | T2279 | arg1Of | activation,is |
R1874 | T2278 | T2280 | arg1Of | activation,important |
R1875 | T2279 | T2275 | arg2Of | is,identified |
R1876 | T2279 | T2276 | arg1Of | is,that |
R1877 | T2280 | T2279 | arg2Of | important,is |
R1878 | T2280 | T2281 | arg1Of | important,in |
R1880 | T2284 | T2281 | arg2Of | survival,in |
R1881 | T2284 | T2282 | arg1Of | survival,M-CSF-induced |
R1882 | T2284 | T2283 | arg1Of | survival,monocyte |
R1883 | T2284 | T2285 | arg1Of | survival,[ |
R1884 | T2286 | T2285 | arg2Of | 7,[ |
R1886 | T2287 | T2285 | arg3Of | ],[ |
R1887 | T2289 | T2288 | arg2Of | addition,In |
R1888 | T2289 | T2290 | arg1Of | addition,to |
R1890 | T2292 | T2290 | arg2Of | role,to |
R1891 | T2292 | T2291 | arg1Of | role,its |
R1892 | T2292 | T2293 | arg1Of | role,in |
R1895 | T2296 | T2293 | arg2Of | survival,in |
R1896 | T2296 | T2294 | arg1Of | survival,mononuclear |
R1897 | T2296 | T2295 | arg1Of | survival,phagocyte |
R1899 | T2301 | T2298 | arg1Of | NF-κB,the |
R1900 | T2301 | T2299 | arg1Of | NF-κB,transcription |
R1901 | T2301 | T2300 | arg1Of | NF-κB,factor |
R1902 | T2301 | T2302 | arg1Of | NF-κB,regulates |
R1903 | T2302 | T2288 | arg1Of | regulates,In |
R1904 | T2302 | T2297 | arg1Of | regulates,"," |
R1906 | T2304 | T2302 | arg2Of | genes,regulates |
R1907 | T2304 | T2303 | arg1Of | genes,numerous |
R1908 | T2304 | T2305 | arg1Of | genes,that |
R1909 | T2304 | T2306 | arg1Of | genes,play |
R1910 | T2306 | T2309 | arg1Of | play,in |
R1912 | T2306 | T2324 | arg1Of | play,[ |
R1914 | T2308 | T2306 | arg2Of | roles,play |
R1915 | T2308 | T2307 | arg1Of | roles,important |
R1917 | T2311 | T2310 | arg1Of | signaling,cellular |
R1918 | T2311 | T2312 | arg1Of | signaling,"," |
R1920 | T2312 | T2315 | arg1Of | ",","," |
R1921 | T2314 | T2312 | arg2Of | response,"," |
R1922 | T2314 | T2313 | arg1Of | response,stress |
R1923 | T2315 | T2318 | arg1Of | ",","," |
R1924 | T2317 | T2315 | arg2Of | growth,"," |
R1925 | T2317 | T2316 | arg1Of | growth,cell |
R1927 | T2318 | T2320 | arg1Of | ",","," |
R1928 | T2319 | T2318 | arg2Of | survival,"," |
R1929 | T2320 | T2322 | arg1Of | ",",and |
R1931 | T2321 | T2320 | arg2Of | differentiation,"," |
R1932 | T2322 | T2309 | arg2Of | and,in |
R1934 | T2323 | T2322 | arg2Of | inflammation,and |
R1935 | T2325 | T2324 | arg2Of | 8,[ |
R1937 | T2326 | T2324 | arg3Of | ],[ |
R1938 | T2327 | T2328 | arg1Of | There,are |
R1939 | T2328 | T2335 | arg1Of | are,: |
R1941 | T2330 | T2328 | arg2Of | members,are |
R1942 | T2330 | T2329 | arg1Of | members,five |
R1943 | T2330 | T2331 | arg1Of | members,in |
R1945 | T2334 | T2331 | arg2Of | family,in |
R1946 | T2334 | T2332 | arg1Of | family,the |
R1947 | T2334 | T2333 | arg1Of | family,NF-κB |
R1949 | T2336 | T2337 | arg1Of | RelA/p65,"," |
R1950 | T2337 | T2339 | arg1Of | ",","," |
R1952 | T2338 | T2337 | arg2Of | p50,"," |
R1953 | T2339 | T2341 | arg1Of | ",","," |
R1958 | T2340 | T2339 | arg2Of | p52,"," |
R1959 | T2341 | T2343 | arg1Of | ",",and |
R1961 | T2342 | T2341 | arg2Of | c-Rel,"," |
R1962 | T2344 | T2343 | arg2Of | RelB,and |
R1965 | T2347 | T2346 | arg1Of | common,most |
R1967 | T2349 | T2345 | arg1Of | complex,The |
R1968 | T2349 | T2347 | arg1Of | complex,common |
R1969 | T2349 | T2348 | arg1Of | complex,activating |
R1970 | T2349 | T2350 | arg1Of | complex,is |
R1971 | T2349 | T2355 | arg2Of | complex,driven |
R1972 | T2350 | T2354 | arg1Of | is,"," |
R1973 | T2350 | T2355 | modOf | is,driven |
R1974 | T2353 | T2350 | arg2Of | heterodimer,is |
R1975 | T2353 | T2351 | arg1Of | heterodimer,the |
R1976 | T2353 | T2352 | arg1Of | heterodimer,p50/p65 |
R1979 | T2359 | T2355 | arg1Of | domain,driven |
R1980 | T2359 | T2356 | arg2Of | domain,by |
R1981 | T2359 | T2357 | arg1Of | domain,the |
R1982 | T2359 | T2358 | arg1Of | domain,activation |
R1983 | T2359 | T2360 | arg1Of | domain,in |
R1985 | T2364 | T2360 | arg2Of | subunit,in |
R1986 | T2364 | T2361 | arg1Of | subunit,the |
R1987 | T2364 | T2362 | arg1Of | subunit,NF-κB |
R1988 | T2364 | T2363 | arg1Of | subunit,p65 |
R1989 | T2438 | T2437 | arg1Of | active,constitutively |
R1990 | T2366 | T2365 | arg1Of | p65,NF-κB |
R1991 | T2366 | T2367 | arg1Of | p65,regulates |
R1992 | T2367 | T2371 | arg1Of | regulates,[ |
R1993 | T2367 | T2374 | arg1Of | regulates,"," |
R1994 | T2367 | T2375 | arg1Of | regulates,[ |
R1995 | T2370 | T2367 | arg2Of | processes,regulates |
R1996 | T2370 | T2368 | arg1Of | processes,important |
R1997 | T2370 | T2369 | arg1Of | processes,developmental |
R1998 | T2439 | T2435 | arg1Of | NF-κB,mediated |
R1999 | T2372 | T2371 | arg2Of | 9,[ |
R2000 | T2373 | T2371 | arg3Of | ],[ |
R2001 | T2439 | T2436 | arg2Of | NF-κB,by |
R2002 | T2439 | T2438 | arg1Of | NF-κB,active |
R2003 | T2376 | T2375 | arg2Of | 10,[ |
R2004 | T2439 | T2440 | arg1Of | NF-κB,in |
R2005 | T2377 | T2375 | arg3Of | ],[ |
R2006 | T2442 | T2440 | arg2Of | macrophages,in |
R2007 | T2378 | T2379 | arg1Of | Mice,lacking |
R2008 | T2378 | T2386 | arg1Of | Mice,have |
R2009 | T2379 | T2383 | arg1Of | lacking,in |
R2010 | T2382 | T2379 | arg2Of | die,lacking |
R2011 | T2382 | T2380 | arg1Of | die,NF-κB |
R2012 | T2382 | T2381 | arg1Of | die,p65 |
R2013 | T2442 | T2441 | arg1Of | macrophages,murine |
R2014 | T2384 | T2383 | arg2Of | utero,in |
R2015 | T2442 | T2443 | arg1Of | macrophages,[ |
R2016 | T2444 | T2443 | arg2Of | 11,[ |
R2017 | T2386 | T2385 | arg1Of | have,and |
R2018 | T2389 | T2386 | arg2Of | damage,have |
R2019 | T2445 | T2443 | arg3Of | ],[ |
R2020 | T2389 | T2387 | arg1Of | damage,extensive |
R2021 | T2389 | T2388 | arg1Of | damage,liver |
R2022 | T2389 | T2390 | arg1Of | damage,via |
R2023 | T2392 | T2390 | arg2Of | apoptosis,via |
R2024 | T2392 | T2391 | arg2Of | apoptosis,enhanced |
R2025 | T2392 | T2393 | arg1Of | apoptosis,[ |
R2026 | T2394 | T2393 | arg2Of | 9,[ |
R2027 | T2395 | T2393 | arg3Of | ],[ |
R2028 | T2447 | T2448 | arg1Of | monocytes,and |
R2029 | T2397 | T2396 | arg1Of | macrophages,Embryonic |
R2030 | T2397 | T2398 | arg1Of | macrophages,from |
R2031 | T2397 | T2403 | arg1Of | macrophages,are |
R2032 | T2397 | T2404 | arg1Of | macrophages,susceptible |
R2033 | T2448 | T2446 | arg2Of | and,In |
R2034 | T2449 | T2448 | arg2Of | macrophages,and |
R2035 | T2402 | T2398 | arg2Of | mice,from |
R2036 | T2402 | T2399 | arg1Of | mice,NF-κB |
R2037 | T2402 | T2400 | arg1Of | mice,p65 |
R2038 | T2402 | T2401 | arg1Of | mice,null |
R2039 | T2404 | T2403 | arg2Of | susceptible,are |
R2040 | T2404 | T2405 | arg1Of | susceptible,to |
R2041 | T2451 | T2452 | arg1Of | NF-κB,is |
R2042 | T2407 | T2405 | arg2Of | apoptosis,to |
R2043 | T2407 | T2406 | arg1Of | apoptosis,TNFα-induced |
R2044 | T2407 | T2408 | arg1Of | apoptosis,which |
R2045 | T2407 | T2409 | arg1Of | apoptosis,is |
R2046 | T2407 | T2410 | arg2Of | apoptosis,rescued |
R2047 | T2452 | T2446 | arg1Of | is,In |
R2048 | T2410 | T2409 | arg2Of | rescued,is |
R2049 | T2410 | T2411 | arg1Of | rescued,by |
R2050 | T2412 | T2411 | arg2Of | overexpressing,by |
R2051 | T2412 | T2417 | arg1Of | overexpressing,[ |
R2052 | T2452 | T2450 | arg1Of | is,"," |
R2053 | T2456 | T2452 | arg2Of | factor,is |
R2054 | T2416 | T2412 | arg2Of | subunit,overexpressing |
R2055 | T2416 | T2413 | arg1Of | subunit,the |
R2056 | T2416 | T2414 | arg1Of | subunit,NF-κB |
R2057 | T2416 | T2415 | arg1Of | subunit,p65 |
R2058 | T2418 | T2417 | arg2Of | 10,[ |
R2059 | T2419 | T2417 | arg3Of | ],[ |
R2060 | T2422 | T2424 | arg1Of | inhibiting,induces |
R2061 | T2456 | T2453 | arg1Of | factor,an |
R2062 | T2423 | T2422 | arg2Of | NF-κB,inhibiting |
R2063 | T2456 | T2454 | arg1Of | factor,important |
R2064 | T2424 | T2427 | arg1Of | induces,in |
R2065 | T2456 | T2455 | arg1Of | factor,transcriptional |
R2066 | T2424 | T2431 | arg1Of | induces,and |
R2067 | T2426 | T2424 | arg2Of | death,induces |
R2068 | T2426 | T2425 | arg1Of | death,cell |
R2069 | T2456 | T2457 | arg1Of | factor,for |
R2070 | T2458 | T2457 | arg2Of | expression,for |
R2071 | T2430 | T2427 | arg2Of | types,in |
R2072 | T2430 | T2428 | arg1Of | types,many |
R2073 | T2430 | T2429 | arg1Of | types,cell |
R2074 | T2431 | T2420 | arg1Of | and,Moreover |
R2075 | T2431 | T2421 | arg1Of | and,"," |
R2076 | T2433 | T2432 | arg1Of | survival,cytokine-independent |
R2077 | T2433 | T2434 | arg1Of | survival,is |
R2078 | T2433 | T2435 | arg2Of | survival,mediated |
R2079 | T2435 | T2431 | arg2Of | mediated,and |
R2080 | T2435 | T2434 | arg2Of | mediated,is |
R2081 | T2458 | T2459 | arg1Of | expression,of |
R2082 | T2460 | T2461 | arg1Of | cytokines,and |
R2083 | T2461 | T2459 | arg2Of | and,of |
R2084 | T2464 | T2461 | arg2Of | receptors,and |
R2085 | T2534 | T2533 | arg2Of | 15,[ |
R2086 | T2464 | T2462 | arg1Of | receptors,cell |
R2087 | T2535 | T2533 | arg3Of | ],[ |
R2088 | T2464 | T2463 | arg1Of | receptors,surface |
R2089 | T2464 | T2465 | arg1Of | receptors,[ |
R2090 | T2537 | T2536 | arg2Of | stimulation,Upon |
R2091 | T2537 | T2538 | arg1Of | stimulation,by |
R2092 | T2466 | T2465 | arg2Of | 12,[ |
R2093 | T2539 | T2540 | arg1Of | cytokines,or |
R2094 | T2540 | T2538 | arg2Of | or,by |
R2095 | T2467 | T2465 | arg3Of | ],[ |
R2096 | T2542 | T2540 | arg2Of | radiation,or |
R2097 | T2542 | T2541 | arg1Of | radiation,UV |
R2098 | T2544 | T2545 | arg1Of | IκBα,is |
R2099 | T2544 | T2546 | arg2Of | IκBα,phosphorylated |
R2100 | T2472 | T2470 | arg2Of | T-cells,unlike |
R2101 | T2544 | T2548 | arg2Of | IκBα,ubiquitinated |
R2102 | T2544 | T2551 | arg2Of | IκBα,degraded |
R2103 | T2544 | T2553 | arg1Of | IκBα,releasing |
R2104 | T2546 | T2547 | arg1Of | phosphorylated,"," |
R2105 | T2547 | T2550 | arg1Of | ",",and |
R2106 | T2548 | T2547 | arg2Of | ubiquitinated,"," |
R2107 | T2472 | T2471 | arg1Of | T-cells,resting |
R2108 | T2474 | T2475 | arg1Of | NF-κB,is |
R2109 | T2550 | T2536 | arg1Of | and,Upon |
R2110 | T2550 | T2543 | arg1Of | and,"," |
R2111 | T2550 | T2545 | arg2Of | and,is |
R2112 | T2550 | T2549 | arg1Of | and,"," |
R2113 | T2550 | T2552 | arg1Of | and,"," |
R2114 | T2550 | T2553 | modOf | and,releasing |
R2115 | T2551 | T2550 | arg2Of | degraded,and |
R2116 | T2474 | T2477 | arg1Of | NF-κB,present |
R2117 | T2555 | T2553 | arg2Of | p50/p65,releasing |
R2118 | T2475 | T2468 | arg1Of | is,However |
R2119 | T2555 | T2554 | arg1Of | p50/p65,NF-κB |
R2120 | T2555 | T2557 | arg1Of | p50/p65,translocate |
R2121 | T2555 | T2562 | arg1Of | p50/p65,transactivate |
R2122 | T2557 | T2558 | arg1Of | translocate,to |
R2123 | T2557 | T2561 | arg1Of | translocate,and |
R2124 | T2560 | T2558 | arg2Of | nucleus,to |
R2125 | T2560 | T2559 | arg1Of | nucleus,the |
R2126 | T2475 | T2469 | arg1Of | is,"," |
R2127 | T2561 | T2553 | arg3Of | and,releasing |
R2128 | T2561 | T2556 | arg1Of | and,to |
R2129 | T2562 | T2561 | arg2Of | transactivate,and |
R2130 | T2475 | T2470 | arg1Of | is,unlike |
R2131 | T2564 | T2562 | arg2Of | genes,transactivate |
R2132 | T2564 | T2563 | arg1Of | genes,target |
R2133 | T2475 | T2473 | arg1Of | is,"," |
R2134 | T2475 | T2494 | arg1Of | is,as |
R2135 | T2567 | T2565 | arg2Of | release,After |
R2136 | T2567 | T2566 | arg1Of | release,its |
R2137 | T2567 | T2568 | arg1Of | release,from |
R2138 | T2475 | T2500 | arg1Of | is,[ |
R2139 | T2569 | T2568 | arg2Of | IκBα,from |
R2140 | T2477 | T2475 | arg2Of | present,is |
R2141 | T2572 | T2571 | arg1Of | p65,NF-κB |
R2142 | T2572 | T2573 | arg1Of | p65,can |
R2143 | T2572 | T2574 | arg1Of | p65,undergo |
R2144 | T2574 | T2565 | arg1Of | undergo,After |
R2145 | T2574 | T2570 | arg1Of | undergo,"," |
R2146 | T2574 | T2573 | arg2Of | undergo,can |
R2147 | T2477 | T2476 | arg1Of | present,constitutively |
R2148 | T2576 | T2574 | arg2Of | modification,undergo |
R2149 | T2576 | T2575 | arg1Of | modification,post-translational |
R2150 | T2576 | T2577 | modOf | modification,to |
R2151 | T2477 | T2478 | arg1Of | present,in |
R2152 | T2578 | T2577 | arg1Of | activate,to |
R2153 | T2480 | T2478 | arg2Of | nuclei,in |
R2154 | T2580 | T2578 | arg2Of | transcription,activate |
R2155 | T2580 | T2579 | arg1Of | transcription,gene |
R2156 | T2582 | T2581 | arg1Of | role,The |
R2157 | T2582 | T2583 | arg1Of | role,of |
R2158 | T2582 | T2587 | arg1Of | role,on |
R2159 | T2582 | T2591 | arg1Of | role,varies |
R2160 | T2480 | T2479 | arg1Of | nuclei,the |
R2161 | T2480 | T2481 | arg1Of | nuclei,of |
R2162 | T2586 | T2583 | arg2Of | phosphorylation,of |
R2163 | T2586 | T2584 | arg1Of | phosphorylation,NF-κB |
R2164 | T2586 | T2585 | arg1Of | phosphorylation,p65 |
R2165 | T2483 | T2482 | arg1Of | monocytes,primary |
R2166 | T2590 | T2587 | arg2Of | activity,on |
R2167 | T2590 | T2588 | arg1Of | activity,NF-κB |
R2168 | T2590 | T2589 | arg1Of | activity,transcriptional |
R2169 | T2591 | T2592 | arg1Of | varies,by |
R2170 | T2591 | T2601 | arg1Of | varies,[ |
R2171 | T2483 | T2484 | arg1Of | monocytes,and |
R2172 | T2593 | T2594 | arg1Of | stimulus,"," |
R2173 | T2484 | T2481 | arg2Of | and,of |
R2174 | T2594 | T2598 | arg1Of | ",",and |
R2175 | T2595 | T2594 | arg2Of | time,"," |
R2176 | T2595 | T2596 | arg1Of | time,of |
R2177 | T2597 | T2596 | arg2Of | stimulation,of |
R2178 | T2598 | T2592 | arg2Of | and,by |
R2179 | T2484 | T2488 | arg1Of | and,in |
R2180 | T2487 | T2484 | arg2Of | lines,and |
R2181 | T2600 | T2598 | arg2Of | type,and |
R2182 | T2600 | T2599 | arg1Of | type,cell |
R2183 | T2602 | T2601 | arg2Of | 16,[ |
R2184 | T2603 | T2601 | arg3Of | ],[ |
R2185 | T2605 | T2604 | arg1Of | research,Previous |
R2186 | T2605 | T2606 | arg1Of | research,shows |
R2187 | T2487 | T2485 | arg1Of | lines,monocytic |
R2188 | T2487 | T2486 | arg1Of | lines,cell |
R2189 | T2488 | T2489 | arg1Of | in,the |
R2190 | T2608 | T2609 | arg1Of | phosphorylation,of |
R2191 | T2608 | T2612 | arg1Of | phosphorylation,at |
R2192 | T2608 | T2618 | arg1Of | phosphorylation,plays |
R2193 | T2488 | T2491 | arg1Of | in,of |
R2194 | T2611 | T2609 | arg2Of | p65,of |
R2195 | T2611 | T2610 | arg1Of | p65,NF-κB |
R2196 | T2490 | T2488 | arg2Of | absence,in |
R2197 | T2613 | T2614 | arg1Of | Ser276,"," |
R2198 | T2614 | T2616 | arg1Of | ",",or |
R2199 | T2615 | T2614 | arg2Of | Ser529,"," |
R2200 | T2616 | T2612 | arg2Of | or,at |
R2201 | T2493 | T2488 | arg3Of | stimuli,in |
R2202 | T2617 | T2616 | arg2Of | Ser536,or |
R2203 | T2618 | T2606 | arg2Of | plays,shows |
R2204 | T2618 | T2607 | arg1Of | plays,that |
R2205 | T2618 | T2622 | arg1Of | plays,in |
R2206 | T2493 | T2492 | arg1Of | stimuli,exogenous |
R2207 | T2495 | T2494 | arg2Of | demonstrated,as |
R2208 | T2621 | T2618 | arg2Of | role,plays |
R2209 | T2621 | T2619 | arg1Of | role,an |
R2210 | T2621 | T2620 | arg1Of | role,important |
R2211 | T2623 | T2622 | arg2Of | regulating,in |
R2212 | T2623 | T2628 | arg1Of | regulating,[ |
R2213 | T2499 | T2495 | arg1Of | analysis,demonstrated |
R2214 | T2625 | T2623 | arg2Of | activity,regulating |
R2215 | T2625 | T2624 | arg1Of | activity,transcriptional |
R2216 | T2625 | T2626 | arg1Of | activity,of |
R2217 | T2627 | T2626 | arg2Of | NF-κB,of |
R2218 | T2629 | T2628 | arg2Of | 17,[ |
R2219 | T2630 | T2628 | arg3Of | ],[ |
R2220 | T2499 | T2496 | arg2Of | analysis,by |
R2221 | T2499 | T2497 | arg1Of | analysis,mobility |
R2222 | T2499 | T2498 | arg1Of | analysis,shift |
R2223 | T2501 | T2500 | arg2Of | 13,[ |
R2224 | T2634 | T2631 | arg2Of | fibroblasts,In |
R2225 | T2634 | T2632 | arg1Of | fibroblasts,TNFα-treated |
R2226 | T2634 | T2633 | arg1Of | fibroblasts,murine |
R2227 | T2502 | T2500 | arg3Of | ],[ |
R2228 | T2636 | T2637 | arg1Of | Ser276,of |
R2229 | T2636 | T2640 | arg1Of | Ser276,is |
R2230 | T2636 | T2641 | arg2Of | Ser276,phosphorylated |
R2231 | T2507 | T2505 | arg1Of | NF-κB,constitutively |
R2232 | T2639 | T2637 | arg2Of | p65,of |
R2233 | T2639 | T2638 | arg1Of | p65,NF-κB |
R2234 | T2641 | T2631 | arg1Of | phosphorylated,In |
R2235 | T2641 | T2635 | arg1Of | phosphorylated,"," |
R2236 | T2641 | T2640 | arg2Of | phosphorylated,is |
R2237 | T2641 | T2644 | modOf | phosphorylated,to |
R2238 | T2643 | T2641 | arg1Of | MSK1,phosphorylated |
R2239 | T2643 | T2642 | arg2Of | MSK1,by |
R2240 | T2645 | T2644 | arg1Of | enhance,to |
R2241 | T2507 | T2506 | arg1Of | NF-κB,active |
R2242 | T2648 | T2645 | arg2Of | activity,enhance |
R2243 | T2648 | T2646 | arg1Of | activity,NF-κB |
R2244 | T2648 | T2647 | arg1Of | activity,transcriptional |
R2245 | T2648 | T2649 | arg1Of | activity,[ |
R2246 | T2507 | T2508 | arg1Of | NF-κB,was |
R2247 | T2650 | T2649 | arg2Of | 18,[ |
R2248 | T2651 | T2649 | arg3Of | ],[ |
R2249 | T2507 | T2509 | arg2Of | NF-κB,observed |
R2250 | T2509 | T2503 | arg1Of | observed,Similarly |
R2251 | T2653 | T2652 | arg2Of | macrophages,In |
R2252 | T2653 | T2654 | arg2Of | macrophages,treated |
R2253 | T2654 | T2655 | arg1Of | treated,with |
R2254 | T2656 | T2655 | arg2Of | endotoxin,with |
R2255 | T2509 | T2504 | arg1Of | observed,"," |
R2256 | T2509 | T2508 | arg2Of | observed,was |
R2257 | T2660 | T2658 | arg1Of | activity,NF-κB |
R2258 | T2660 | T2659 | arg1Of | activity,transcription |
R2259 | T2660 | T2661 | arg1Of | activity,is |
R2260 | T2660 | T2662 | arg2Of | activity,associated |
R2261 | T2509 | T2510 | arg1Of | observed,in |
R2262 | T2662 | T2652 | arg1Of | associated,In |
R2263 | T2662 | T2657 | arg1Of | associated,"," |
R2264 | T2662 | T2661 | arg2Of | associated,is |
R2265 | T2662 | T2663 | arg1Of | associated,with |
R2266 | T2509 | T2514 | arg1Of | observed,[ |
R2267 | T2664 | T2663 | arg2Of | phosphorylation,with |
R2268 | T2664 | T2665 | arg1Of | phosphorylation,on |
R2269 | T2513 | T2510 | arg2Of | macrophages,in |
R2270 | T2666 | T2667 | arg1Of | Ser276,and |
R2271 | T2667 | T2665 | arg2Of | and,on |
R2272 | T2667 | T2669 | arg1Of | and,that |
R2273 | T2667 | T2670 | arg1Of | and,is |
R2274 | T2667 | T2671 | arg2Of | and,regulated |
R2275 | T2668 | T2667 | arg2Of | Ser536,and |
R2276 | T2671 | T2670 | arg2Of | regulated,is |
R2277 | T2671 | T2672 | arg1Of | regulated,through |
R2278 | T2671 | T2682 | arg1Of | regulated,[ |
R2279 | T2671 | T2685 | arg1Of | regulated,"," |
R2280 | T2671 | T2686 | arg1Of | regulated,[ |
R2281 | T2675 | T2673 | arg1Of | A,protein |
R2282 | T2675 | T2674 | arg1Of | A,kinase |
R2283 | T2675 | T2676 | arg1Of | A,( |
R2284 | T2675 | T2679 | arg1Of | A,and |
R2285 | T2513 | T2511 | arg1Of | macrophages,human |
R2286 | T2677 | T2676 | arg2Of | PKA,( |
R2287 | T2513 | T2512 | arg1Of | macrophages,alveolar |
R2288 | T2678 | T2676 | arg3Of | ),( |
R2289 | T2679 | T2672 | arg2Of | and,through |
R2290 | T2679 | T2681 | arg1Of | and,respectively |
R2291 | T2515 | T2514 | arg2Of | 14,[ |
R2292 | T2680 | T2679 | arg2Of | IKKβ,and |
R2293 | T2683 | T2682 | arg2Of | 16,[ |
R2294 | T2516 | T2514 | arg3Of | ],[ |
R2295 | T2684 | T2682 | arg3Of | ],[ |
R2296 | T2520 | T2517 | arg2Of | pathway,In |
R2297 | T2687 | T2686 | arg2Of | 19,[ |
R2298 | T2688 | T2686 | arg3Of | ],[ |
R2299 | T2520 | T2518 | arg1Of | pathway,the |
R2300 | T2692 | T2689 | arg2Of | cells,In |
R2301 | T2692 | T2690 | arg1Of | cells,human |
R2302 | T2692 | T2691 | arg1Of | cells,T |
R2303 | T2520 | T2519 | arg1Of | pathway,classic/canonical |
R2304 | T2525 | T2522 | arg1Of | complex,the |
R2305 | T2695 | T2694 | arg1Of | p65,NF-κB |
R2306 | T2695 | T2696 | arg1Of | p65,is |
R2307 | T2695 | T2698 | arg2Of | p65,phosphorylated |
R2308 | T2698 | T2689 | arg1Of | phosphorylated,In |
R2309 | T2698 | T2693 | arg1Of | phosphorylated,"," |
R2310 | T2698 | T2696 | arg2Of | phosphorylated,is |
R2311 | T2698 | T2697 | arg1Of | phosphorylated,constitutively |
R2312 | T2698 | T2699 | arg1Of | phosphorylated,on |
R2313 | T2698 | T2701 | modOf | phosphorylated,to |
R2314 | T2698 | T2710 | arg1Of | phosphorylated,[ |
R2315 | T2525 | T2523 | arg1Of | complex,NF-κB |
R2316 | T2700 | T2699 | arg2Of | Ser536,on |
R2317 | T2525 | T2524 | arg1Of | complex,p50/p65 |
R2318 | T2525 | T2526 | arg1Of | complex,is |
R2319 | T2702 | T2701 | arg1Of | facilitate,to |
R2320 | T2702 | T2707 | arg1Of | facilitate,following |
R2321 | T2525 | T2527 | arg2Of | complex,sequestered |
R2322 | T2527 | T2517 | arg1Of | sequestered,In |
R2323 | T2706 | T2702 | arg2Of | translocation,facilitate |
R2324 | T2706 | T2703 | arg1Of | translocation,NF-κB |
R2325 | T2706 | T2704 | arg1Of | translocation,p65 |
R2326 | T2706 | T2705 | arg1Of | translocation,nuclear |
R2327 | T2709 | T2707 | arg2Of | stimulation,following |
R2328 | T2709 | T2708 | arg1Of | stimulation,cellular |
R2329 | T2711 | T2710 | arg2Of | 20,[ |
R2330 | T2527 | T2521 | arg1Of | sequestered,"," |
R2331 | T2712 | T2710 | arg3Of | ],[ |
R2332 | T2713 | T2715 | arg1Of | Accumulating,reveals |
R2333 | T2527 | T2526 | arg2Of | sequestered,is |
R2334 | T2714 | T2713 | arg2Of | evidence,Accumulating |
R2335 | T2527 | T2528 | arg1Of | sequestered,in |
R2336 | T2530 | T2528 | arg2Of | cytosol,in |
R2337 | T2719 | T2717 | arg1Of | phosphorylation,NF-κB |
R2338 | T2719 | T2718 | arg1Of | phosphorylation,p65 |
R2339 | T2719 | T2720 | arg1Of | phosphorylation,at |
R2340 | T2719 | T2722 | arg1Of | phosphorylation,is |
R2341 | T2719 | T2723 | arg1Of | phosphorylation,crucial |
R2342 | T2721 | T2720 | arg2Of | Ser276,at |
R2343 | T2722 | T2715 | arg2Of | is,reveals |
R2344 | T2722 | T2716 | arg1Of | is,that |
R2345 | T2530 | T2529 | arg1Of | cytosol,the |
R2346 | T2723 | T2722 | arg2Of | crucial,is |
R2347 | T2723 | T2724 | arg1Of | crucial,for |
R2348 | T2530 | T2531 | arg1Of | cytosol,by |
R2349 | T2532 | T2531 | arg2Of | IκBα,by |
R2350 | T2727 | T2724 | arg2Of | activity,for |
R2351 | T2727 | T2725 | arg1Of | activity,its |
R2352 | T2727 | T2726 | arg1Of | activity,transcriptional |
R2353 | T2532 | T2533 | arg1Of | IκBα,[ |
R2354 | T2827 | T2824 | arg2Of | activation,in |
R2355 | T2827 | T2825 | arg1Of | activation,M-CSF-stimulated |
R2356 | T2827 | T2826 | arg1Of | activation,NF-κB |
R2357 | T2730 | T2728 | arg2Of | translocation,Upon |
R2358 | T2730 | T2729 | arg1Of | translocation,nuclear |
R2359 | T2829 | T2828 | arg1Of | proteins,PKC |
R2360 | T2732 | T2733 | arg1Of | phosphorylation,of |
R2361 | T2732 | T2735 | arg1Of | phosphorylation,on |
R2362 | T2732 | T2740 | arg1Of | phosphorylation,recruits |
R2363 | T2734 | T2733 | arg2Of | Ser276,of |
R2364 | T2829 | T2830 | arg1Of | proteins,are |
R2365 | T2832 | T2830 | arg2Of | kinases,are |
R2366 | T2737 | T2735 | arg2Of | p65,on |
R2367 | T2737 | T2736 | arg1Of | p65,NF-κB |
R2368 | T2737 | T2738 | arg1Of | p65,by |
R2369 | T2739 | T2738 | arg2Of | PKA,by |
R2370 | T2740 | T2728 | arg1Of | recruits,Upon |
R2371 | T2740 | T2731 | arg1Of | recruits,"," |
R2372 | T2740 | T2751 | arg1Of | recruits,[ |
R2373 | T2832 | T2831 | arg1Of | kinases,multifunctional |
R2374 | T2743 | T2740 | arg2Of | co-activator,recruits |
R2375 | T2743 | T2741 | arg1Of | co-activator,the |
R2376 | T2743 | T2742 | arg1Of | co-activator,transcription |
R2377 | T2743 | T2744 | arg1Of | co-activator,"," |
R2378 | T2745 | T2744 | arg2Of | p300,"," |
R2379 | T2745 | T2746 | modOf | p300,to |
R2380 | T2747 | T2746 | arg1Of | potentiate,to |
R2381 | T2832 | T2833 | arg1Of | kinases,that |
R2382 | T2832 | T2834 | arg1Of | kinases,differ |
R2383 | T2834 | T2835 | arg1Of | differ,in |
R2384 | T2750 | T2747 | arg2Of | transcription,potentiate |
R2385 | T2750 | T2748 | arg1Of | transcription,NF-κB-regulated |
R2386 | T2750 | T2749 | arg1Of | transcription,gene |
R2387 | T2752 | T2751 | arg2Of | 21,[ |
R2388 | T2753 | T2751 | arg3Of | ],[ |
R2389 | T2836 | T2837 | arg1Of | structure,"," |
R2390 | T2757 | T2756 | arg1Of | studies,other |
R2391 | T2757 | T2758 | arg1Of | studies,show |
R2392 | T2758 | T2754 | arg1Of | show,However |
R2393 | T2758 | T2755 | arg1Of | show,"," |
R2394 | T2837 | T2839 | arg1Of | ",",and |
R2395 | T2760 | T2761 | arg1Of | PKA,inhibits |
R2396 | T2760 | T2766 | arg1Of | PKA,stabilizing |
R2397 | T2761 | T2758 | arg2Of | inhibits,show |
R2398 | T2761 | T2759 | arg1Of | inhibits,that |
R2399 | T2761 | T2765 | arg1Of | inhibits,by |
R2400 | T2838 | T2837 | arg2Of | function,"," |
R2401 | T2764 | T2761 | arg2Of | expression,inhibits |
R2402 | T2764 | T2762 | arg1Of | expression,NF-κB-regulated |
R2403 | T2764 | T2763 | arg1Of | expression,gene |
R2404 | T2839 | T2835 | arg2Of | and,in |
R2405 | T2766 | T2765 | arg2Of | stabilizing,by |
R2406 | T2767 | T2766 | arg2Of | IκBα,stabilizing |
R2407 | T2767 | T2768 | arg1Of | IκBα,[ |
R2408 | T2841 | T2839 | arg2Of | requirement,and |
R2409 | T2767 | T2771 | arg1Of | IκBα,"," |
R2410 | T2767 | T2772 | arg1Of | IκBα,[ |
R2411 | T2769 | T2768 | arg2Of | 22,[ |
R2412 | T2841 | T2840 | arg1Of | requirement,co-factor |
R2413 | T2770 | T2768 | arg3Of | ],[ |
R2414 | T2841 | T2842 | arg1Of | requirement,[ |
R2415 | T2843 | T2842 | arg2Of | 26,[ |
R2416 | T2773 | T2772 | arg2Of | 23,[ |
R2417 | T2774 | T2772 | arg3Of | ],[ |
R2418 | T2844 | T2842 | arg3Of | ],[ |
R2419 | T2845 | T2846 | arg1Of | PKCs,are |
R2420 | T2780 | T2777 | arg1Of | Pim-1,the |
R2421 | T2780 | T2778 | arg1Of | Pim-1,serine/threonine |
R2422 | T2780 | T2779 | arg1Of | Pim-1,kinase |
R2423 | T2780 | T2782 | arg1Of | Pim-1,phosphorylates |
R2424 | T2780 | T2788 | arg1Of | Pim-1,stabilizing |
R2425 | T2782 | T2775 | arg1Of | phosphorylates,Interestingly |
R2426 | T2782 | T2776 | arg1Of | phosphorylates,"," |
R2427 | T2782 | T2781 | arg1Of | phosphorylates,directly |
R2428 | T2782 | T2785 | arg1Of | phosphorylates,at |
R2429 | T2782 | T2787 | arg1Of | phosphorylates,by |
R2430 | T2784 | T2782 | arg2Of | p65,phosphorylates |
R2431 | T2784 | T2783 | arg1Of | p65,NF-κB |
R2432 | T2845 | T2847 | arg2Of | PKCs,involved |
R2433 | T2786 | T2785 | arg2Of | Ser276,at |
R2434 | T2847 | T2846 | arg2Of | involved,are |
R2435 | T2788 | T2787 | arg2Of | stabilizing,by |
R2436 | T2788 | T2789 | modOf | stabilizing,to |
R2437 | T2790 | T2789 | arg1Of | prevent,to |
R2438 | T2847 | T2848 | arg1Of | involved,in |
R2439 | T2792 | T2790 | arg2Of | degradation,prevent |
R2440 | T2792 | T2791 | arg1Of | degradation,ubiquitin-proteasome |
R2441 | T2792 | T2793 | arg1Of | degradation,[ |
R2442 | T2851 | T2848 | arg2Of | responses,in |
R2443 | T2794 | T2793 | arg2Of | 24,[ |
R2444 | T2795 | T2793 | arg3Of | ],[ |
R2445 | T2797 | T2796 | arg1Of | other,Several |
R2446 | T2799 | T2797 | arg1Of | sites,other |
R2447 | T2799 | T2798 | arg1Of | sites,phosphorylation |
R2448 | T2799 | T2800 | arg1Of | sites,are |
R2449 | T2799 | T2802 | arg2Of | sites,described |
R2450 | T2799 | T2804 | arg1Of | sites,enhance |
R2451 | T2851 | T2849 | arg1Of | responses,diverse |
R2452 | T2851 | T2850 | arg1Of | responses,cell |
R2453 | T2802 | T2800 | arg2Of | described,are |
R2454 | T2802 | T2801 | arg1Of | described,also |
R2455 | T2851 | T2852 | arg1Of | responses,"," |
R2456 | T2804 | T2802 | arg3Of | enhance,described |
R2457 | T2804 | T2803 | arg1Of | enhance,to |
R2458 | T2804 | T2808 | arg1Of | enhance,[ |
R2459 | T2851 | T2853 | arg1Of | responses,including |
R2460 | T2855 | T2854 | arg1Of | growth,cell |
R2461 | T2807 | T2804 | arg2Of | transactivation,enhance |
R2462 | T2807 | T2805 | arg1Of | transactivation,NF-κB |
R2463 | T2807 | T2806 | arg1Of | transactivation,gene |
R2464 | T2809 | T2808 | arg2Of | 25,[ |
R2465 | T2810 | T2808 | arg3Of | ],[ |
R2466 | T2813 | T2814 | arg1Of | we,investigate |
R2467 | T2814 | T2811 | arg1Of | investigate,Here |
R2468 | T2814 | T2812 | arg1Of | investigate,"," |
R2469 | T2855 | T2856 | arg1Of | growth,"," |
R2470 | T2816 | T2814 | arg2Of | role,investigate |
R2471 | T2816 | T2815 | arg1Of | role,the |
R2472 | T2816 | T2817 | arg1Of | role,of |
R2473 | T2856 | T2858 | arg1Of | ",","," |
R2474 | T2820 | T2817 | arg2Of | C,of |
R2475 | T2820 | T2818 | arg1Of | C,protein |
R2476 | T2820 | T2819 | arg1Of | C,kinase |
R2477 | T2820 | T2821 | arg1Of | C,( |
R2478 | T2820 | T2824 | arg1Of | C,in |
R2479 | T2822 | T2821 | arg2Of | PKC,( |
R2480 | T2823 | T2821 | arg3Of | ),( |
R2481 | T2857 | T2856 | arg2Of | survival,"," |
R2482 | T2858 | T2860 | arg1Of | ",",and |
R2483 | T2859 | T2858 | arg2Of | differentiation,"," |
R2484 | T2860 | T2853 | arg2Of | and,including |
R2485 | T2861 | T2860 | arg2Of | development,and |
R2486 | T2861 | T2862 | arg1Of | development,[ |
R2487 | T2923 | T2924 | arg1Of | λ,) |
R2488 | T2863 | T2862 | arg2Of | 27,[ |
R2489 | T2925 | T2918 | arg2Of | require,: |
R2490 | T2925 | T2919 | arg1Of | require,ξ |
R2491 | T2925 | T2920 | arg1Of | require,"," |
R2492 | T2925 | T2922 | arg1Of | require,and |
R2493 | T2925 | T2923 | arg1Of | require,λ |
R2494 | T2864 | T2862 | arg3Of | ],[ |
R2495 | T2927 | T2928 | arg1Of | Ca2+,nor |
R2496 | T2928 | T2925 | arg2Of | nor,require |
R2497 | T2928 | T2926 | arg1Of | nor,neither |
R2498 | T2868 | T2867 | arg1Of | related,closely |
R2499 | T2929 | T2928 | arg2Of | DAG,nor |
R2500 | T2930 | T2931 | arg1Of | Monocytes,and |
R2501 | T2931 | T2934 | arg1Of | and,express |
R2502 | T2932 | T2931 | arg2Of | macrophages,and |
R2503 | T2869 | T2865 | arg1Of | enzymes,The |
R2504 | T2934 | T2933 | arg1Of | express,predominantly |
R2505 | T2869 | T2866 | arg1Of | enzymes,12 |
R2506 | T2937 | T2935 | arg1Of | isoforms,conventional |
R2507 | T2937 | T2936 | arg1Of | isoforms,PKC |
R2508 | T2937 | T2938 | arg1Of | isoforms,( |
R2509 | T2937 | T2944 | arg1Of | isoforms,and |
R2510 | T2869 | T2868 | arg1Of | enzymes,related |
R2511 | T2869 | T2870 | arg1Of | enzymes,of |
R2512 | T2940 | T2939 | arg1Of | PKCβI,PKCα |
R2513 | T2940 | T2941 | arg1Of | PKCβI,and |
R2514 | T2869 | T2874 | arg1Of | enzymes,are |
R2515 | T2941 | T2938 | arg2Of | and,( |
R2516 | T2869 | T2875 | arg2Of | enzymes,divided |
R2517 | T2942 | T2941 | arg2Of | PKCβII,and |
R2518 | T2943 | T2938 | arg3Of | ),( |
R2519 | T2873 | T2870 | arg2Of | family,of |
R2520 | T2944 | T2934 | arg2Of | and,express |
R2521 | T2946 | T2944 | arg2Of | PKCs,and |
R2522 | T2946 | T2945 | arg1Of | PKCs,novel |
R2523 | T2946 | T2947 | arg1Of | PKCs,( |
R2524 | T2948 | T2949 | arg1Of | PKCδ,and |
R2525 | T2949 | T2947 | arg2Of | and,( |
R2526 | T2950 | T2949 | arg2Of | PKCε,and |
R2527 | T2951 | T2947 | arg3Of | ),( |
R2528 | T2873 | T2871 | arg1Of | family,the |
R2529 | T2953 | T2952 | arg1Of | PKCs,Conventional |
R2530 | T2953 | T2954 | arg1Of | PKCs,regulate |
R2531 | T2873 | T2872 | arg1Of | family,PKC |
R2532 | T2955 | T2954 | arg2Of | differentiation,regulate |
R2533 | T2955 | T2956 | arg1Of | differentiation,of |
R2534 | T2955 | T2964 | arg1Of | differentiation,to |
R2535 | T2875 | T2874 | arg2Of | divided,are |
R2536 | T2875 | T2876 | arg1Of | divided,into |
R2537 | T2875 | T2883 | arg1Of | divided,: |
R2538 | T2878 | T2876 | arg2Of | classes,into |
R2539 | T2963 | T2956 | arg2Of | HL60,of |
R2540 | T2963 | T2957 | arg1Of | HL60,the |
R2541 | T2963 | T2958 | arg1Of | HL60,human |
R2542 | T2963 | T2959 | arg1Of | HL60,promyelocytic |
R2543 | T2963 | T2960 | arg1Of | HL60,leukemia |
R2544 | T2963 | T2961 | arg1Of | HL60,cell |
R2545 | T2963 | T2962 | arg1Of | HL60,line |
R2546 | T2965 | T2964 | arg2Of | macrophages,to |
R2547 | T2965 | T2966 | arg1Of | macrophages,[ |
R2548 | T2967 | T2966 | arg2Of | 28,[ |
R2549 | T2968 | T2966 | arg3Of | ],[ |
R2550 | T2969 | T2970 | arg1Of | PKCα,induces |
R2551 | T2878 | T2877 | arg1Of | classes,three |
R2552 | T2970 | T2978 | arg1Of | induces,after |
R2553 | T2970 | T2984 | arg1Of | induces,[ |
R2554 | T2971 | T2972 | arg1Of | IL-1α,"," |
R2555 | T2878 | T2879 | arg1Of | classes,: |
R2556 | T2972 | T2974 | arg1Of | ",",and |
R2557 | T2882 | T2879 | arg2Of | cPKCs,: |
R2558 | T2973 | T2972 | arg2Of | iNOS,"," |
R2559 | T2974 | T2970 | arg2Of | and,induces |
R2560 | T2977 | T2974 | arg2Of | production,and |
R2561 | T2977 | T2975 | arg1Of | production,TNFα |
R2562 | T2977 | T2976 | arg1Of | production,mRNA |
R2563 | T2979 | T2980 | arg1Of | lipopolysaccharide,( |
R2564 | T2882 | T2880 | arg1Of | cPKCs,conventional |
R2565 | T2981 | T2980 | arg2Of | LPS,( |
R2566 | T2882 | T2881 | arg1Of | cPKCs,( |
R2567 | T2982 | T2980 | arg3Of | ),( |
R2568 | T2886 | T2885 | arg1Of | βII,βI |
R2569 | T2983 | T2978 | arg2Of | exposure,after |
R2570 | T2983 | T2979 | arg1Of | exposure,lipopolysaccharide |
R2571 | T2985 | T2984 | arg2Of | 29,[ |
R2572 | T2986 | T2984 | arg3Of | ],[ |
R2573 | T2988 | T2987 | arg2Of | addition,In |
R2574 | T2886 | T2887 | arg1Of | βII,and |
R2575 | T2990 | T2992 | arg1Of | accumulating,suggests |
R2576 | T2991 | T2990 | arg2Of | evidence,accumulating |
R2577 | T2992 | T2987 | arg1Of | suggests,In |
R2578 | T2992 | T2989 | arg1Of | suggests,"," |
R2579 | T2887 | T2884 | arg1Of | and,α |
R2580 | T2995 | T2994 | arg1Of | PKCs,conventional |
R2581 | T2995 | T2996 | arg1Of | PKCs,like |
R2582 | T2995 | T2998 | arg1Of | PKCs,have |
R2583 | T2887 | T2889 | arg1Of | and,require |
R2584 | T2997 | T2996 | arg2Of | PKCα,like |
R2585 | T2888 | T2887 | arg2Of | γ,and |
R2586 | T2998 | T2992 | arg2Of | have,suggests |
R2587 | T2998 | T2993 | arg1Of | have,that |
R2588 | T3000 | T2998 | arg2Of | functions,have |
R2589 | T2889 | T2883 | arg2Of | require,: |
R2590 | T3000 | T2999 | arg1Of | functions,anti-apoptotic |
R2591 | T2889 | T2900 | arg1Of | require,: |
R2592 | T2890 | T2891 | arg1Of | Ca2+,and |
R2593 | T3002 | T3001 | arg2Of | example,For |
R2594 | T2891 | T2889 | arg2Of | and,require |
R2595 | T3004 | T3005 | arg1Of | PKCα,is |
R2596 | T3004 | T3006 | arg2Of | PKCα,overexpressed |
R2597 | T3006 | T3001 | arg1Of | overexpressed,For |
R2598 | T3006 | T3003 | arg1Of | overexpressed,"," |
R2599 | T3006 | T3005 | arg2Of | overexpressed,is |
R2600 | T3006 | T3007 | arg1Of | overexpressed,in |
R2601 | T2891 | T2893 | arg1Of | and,( |
R2602 | T2891 | T2896 | arg1Of | and,; |
R2603 | T3009 | T3007 | arg2Of | variety,in |
R2604 | T3009 | T3008 | arg1Of | variety,a |
R2605 | T3009 | T3010 | arg1Of | variety,of |
R2606 | T2892 | T2891 | arg2Of | diacylglycerol,and |
R2607 | T3012 | T3010 | arg2Of | cells,of |
R2608 | T3012 | T3011 | arg1Of | cells,tumor |
R2609 | T3012 | T3013 | arg1Of | cells,including |
R2610 | T2894 | T2893 | arg2Of | DAG,( |
R2611 | T3014 | T3015 | arg1Of | gliomas,"," |
R2612 | T3015 | T3018 | arg1Of | ",",and |
R2613 | T3016 | T3015 | arg2Of | liver,"," |
R2614 | T2895 | T2893 | arg3Of | ),( |
R2615 | T3018 | T3013 | arg2Of | and,including |
R2616 | T3018 | T3017 | arg1Of | and,"," |
R2617 | T3018 | T3023 | arg1Of | and,"," |
R2618 | T3018 | T3024 | arg1Of | and,[ |
R2619 | T2899 | T2896 | arg2Of | nPKCs,; |
R2620 | T3019 | T3018 | arg2Of | lung,and |
R2621 | T3019 | T3020 | arg1Of | lung,[ |
R2622 | T2899 | T2897 | arg1Of | nPKCs,novel |
R2623 | T3021 | T3020 | arg2Of | 30,[ |
R2624 | T2899 | T2898 | arg1Of | nPKCs,( |
R2625 | T3022 | T3020 | arg3Of | ],[ |
R2626 | T2907 | T2911 | arg1Of | θ,require |
R2627 | T3025 | T3024 | arg2Of | 31,[ |
R2628 | T3026 | T3024 | arg3Of | ],[ |
R2629 | T3029 | T3027 | arg2Of | cells,In |
R2630 | T3029 | T3028 | arg1Of | cells,epithelial |
R2631 | T3031 | T3032 | arg1Of | inhibition,of |
R2632 | T3031 | T3034 | arg1Of | inhibition,induces |
R2633 | T3033 | T3032 | arg2Of | PKCα,of |
R2634 | T3034 | T3027 | arg1Of | induces,In |
R2635 | T3034 | T3030 | arg1Of | induces,"," |
R2636 | T3036 | T3034 | arg2Of | apoptosis,induces |
R2637 | T3036 | T3035 | arg1Of | apoptosis,PKCδ-dependent |
R2638 | T3036 | T3037 | arg1Of | apoptosis,[ |
R2639 | T2909 | T2910 | arg1Of | μ,) |
R2640 | T3038 | T3037 | arg2Of | 31,[ |
R2641 | T3039 | T3037 | arg3Of | ],[ |
R2642 | T2911 | T2874 | modOf | require,are |
R2643 | T3044 | T3043 | arg1Of | monocytes,human |
R2644 | T3044 | T3045 | arg1Of | monocytes,and |
R2645 | T2911 | T2901 | arg1Of | require,δ |
R2646 | T3045 | T3042 | arg2Of | and,in |
R2647 | T2911 | T2902 | arg1Of | require,"," |
R2648 | T2911 | T2903 | arg1Of | require,ε |
R2649 | T2911 | T2904 | arg1Of | require,"," |
R2650 | T2911 | T2905 | arg1Of | require,η |
R2651 | T3049 | T3045 | arg2Of | cells,and |
R2652 | T3049 | T3046 | arg1Of | cells,premonocytic |
R2653 | T3049 | T3047 | arg1Of | cells,THP-1 |
R2654 | T3049 | T3048 | arg1Of | cells,leukemia |
R2655 | T2911 | T2906 | arg1Of | require,"," |
R2656 | T2911 | T2908 | arg1Of | require,and |
R2657 | T3052 | T3051 | arg1Of | PKCs,novel |
R2658 | T3052 | T3053 | arg1Of | PKCs,like |
R2659 | T3052 | T3055 | arg1Of | PKCs,have |
R2660 | T2911 | T2909 | arg1Of | require,μ |
R2661 | T3054 | T3053 | arg2Of | PKCδ,like |
R2662 | T2911 | T2912 | arg1Of | require,DAG |
R2663 | T3055 | T3059 | arg1Of | have,on |
R2664 | T3055 | T3062 | arg1Of | have,"," |
R2665 | T2911 | T2915 | arg1Of | require,atypical |
R2666 | T2912 | T2914 | arg1Of | DAG,and |
R2667 | T3058 | T3055 | arg2Of | effect,have |
R2668 | T3058 | T3056 | arg1Of | effect,the |
R2669 | T3058 | T3057 | arg1Of | effect,opposite |
R2670 | T2914 | T2913 | arg1Of | and,; |
R2671 | T3061 | T3059 | arg2Of | survival,on |
R2672 | T3061 | T3060 | arg1Of | survival,cell |
R2673 | T3062 | T3040 | arg1Of | ",",Interestingly |
R2674 | T3062 | T3041 | arg1Of | ",","," |
R2675 | T3062 | T3042 | arg1Of | ",",in |
R2676 | T3062 | T3050 | arg1Of | ",","," |
R2677 | T3065 | T3063 | arg1Of | al,Voss |
R2678 | T3065 | T3064 | arg1Of | al,et |
R2679 | T3065 | T3066 | arg1Of | al,showed |
R2680 | T3066 | T3062 | arg2Of | showed,"," |
R2681 | T2915 | T2914 | arg2Of | atypical,and |
R2682 | T3068 | T3070 | arg1Of | PKCδ,phosphorylates |
R2683 | T3068 | T3073 | arg1Of | PKCδ,promotes |
R2684 | T3070 | T3069 | arg1Of | phosphorylates,directly |
R2685 | T3070 | T3072 | arg1Of | phosphorylates,and |
R2686 | T2917 | T2911 | arg2Of | aPKCs,require |
R2687 | T3071 | T3070 | arg2Of | caspase-3,phosphorylates |
R2688 | T3072 | T3066 | arg2Of | and,showed |
R2689 | T3072 | T3067 | arg1Of | and,that |
R2690 | T3073 | T3072 | arg2Of | promotes,and |
R2691 | T3075 | T3073 | arg2Of | apoptosis,promotes |
R2692 | T3075 | T3074 | arg1Of | apoptosis,etoposide-induced |
R2693 | T2917 | T2916 | arg1Of | aPKCs,( |
R2694 | T2917 | T2918 | arg1Of | aPKCs,: |
R2695 | T3075 | T3076 | arg1Of | apoptosis,[ |
R2696 | T2921 | T2925 | arg1Of | ι,require |
R2697 | T3077 | T3076 | arg2Of | 32,[ |
R2698 | T3078 | T3076 | arg3Of | ],[ |
R2699 | T3119 | T3116 | arg2Of | pathway,of |
R2700 | T3083 | T3081 | arg1Of | studies,knockout |
R2701 | T3083 | T3082 | arg1Of | studies,mouse |
R2702 | T3083 | T3084 | arg1Of | studies,suggest |
R2703 | T3084 | T3079 | arg1Of | suggest,Moreover |
R2704 | T3084 | T3080 | arg1Of | suggest,"," |
R2705 | T3088 | T3086 | arg1Of | PKC,another |
R2706 | T3088 | T3087 | arg1Of | PKC,novel |
R2707 | T3088 | T3089 | arg1Of | PKC,"," |
R2708 | T3088 | T3091 | arg1Of | PKC,is |
R2709 | T3088 | T3093 | arg2Of | PKC,involved |
R2710 | T3090 | T3089 | arg2Of | PKCε,"," |
R2711 | T3119 | T3117 | arg1Of | pathway,the |
R2712 | T3093 | T3084 | arg2Of | involved,suggest |
R2713 | T3093 | T3085 | arg1Of | involved,that |
R2714 | T3093 | T3091 | arg2Of | involved,is |
R2715 | T3093 | T3092 | arg1Of | involved,critically |
R2716 | T3093 | T3094 | arg1Of | involved,in |
R2717 | T3093 | T3101 | arg1Of | involved,[ |
R2718 | T3119 | T3118 | arg1Of | pathway,PI3-K/AKT |
R2719 | T3119 | T3120 | arg1Of | pathway,[ |
R2720 | T3121 | T3120 | arg2Of | 3,[ |
R2721 | T3097 | T3094 | arg2Of | signaling,in |
R2722 | T3097 | T3095 | arg1Of | signaling,early |
R2723 | T3097 | T3096 | arg1Of | signaling,LPS-mediated |
R2724 | T3097 | T3098 | arg1Of | signaling,in |
R2725 | T3100 | T3098 | arg2Of | macrophages,in |
R2726 | T3100 | T3099 | arg2Of | macrophages,activated |
R2727 | T3102 | T3101 | arg2Of | 33,[ |
R2728 | T3103 | T3101 | arg3Of | ],[ |
R2729 | T3122 | T3120 | arg3Of | ],[ |
R2730 | T3106 | T3107 | arg1Of | we,reported |
R2731 | T3107 | T3104 | arg1Of | reported,Previously |
R2732 | T3107 | T3105 | arg1Of | reported,"," |
R2733 | T3123 | T3125 | arg1Of | In,to |
R2734 | T3109 | T3110 | arg1Of | M-CSF,promotes |
R2735 | T3124 | T3123 | arg2Of | addition,In |
R2736 | T3110 | T3107 | arg2Of | promotes,reported |
R2737 | T3110 | T3108 | arg1Of | promotes,that |
R2738 | T3110 | T3113 | arg1Of | promotes,through |
R2739 | T3112 | T3110 | arg2Of | survival,promotes |
R2740 | T3112 | T3111 | arg1Of | survival,monocyte |
R2741 | T3127 | T3123 | arg3Of | activation,In |
R2742 | T3115 | T3113 | arg2Of | activation,through |
R2743 | T3115 | T3114 | arg1Of | activation,the |
R2744 | T3115 | T3116 | arg1Of | activation,of |
R2745 | T3127 | T3126 | arg1Of | activation,AKT |
R2746 | T3129 | T3130 | arg1Of | M-CSF,stimulates |
R2747 | T3129 | T3136 | arg1Of | M-CSF,increases |
R2748 | T3213 | T3210 | arg2Of | and,of |
R2749 | T3130 | T3132 | arg1Of | stimulates,in |
R2750 | T3130 | T3135 | arg1Of | stimulates,and |
R2751 | T3216 | T3213 | arg2Of | survival,and |
R2752 | T3216 | T3214 | arg1Of | survival,M-CSF-induced |
R2753 | T3216 | T3215 | arg1Of | survival,monocyte |
R2754 | T3131 | T3130 | arg2Of | PKC,stimulates |
R2755 | T3218 | T3219 | arg1Of | we,demonstrates |
R2756 | T3219 | T3217 | arg1Of | demonstrates,Here |
R2757 | T3134 | T3132 | arg2Of | monocytes,in |
R2758 | T3221 | T3222 | arg1Of | M-CSF,upregulated |
R2759 | T3222 | T3219 | arg2Of | upregulated,demonstrates |
R2760 | T3222 | T3220 | arg1Of | upregulated,that |
R2761 | T3134 | T3133 | arg1Of | monocytes,human |
R2762 | T3225 | T3224 | arg1Of | transcription,NF-κB |
R2763 | T3225 | T3226 | arg1Of | transcription,and |
R2764 | T3135 | T3123 | arg1Of | and,In |
R2765 | T3226 | T3222 | arg2Of | and,upregulated |
R2766 | T3226 | T3223 | arg1Of | and,the |
R2767 | T3135 | T3128 | arg1Of | and,"," |
R2768 | T3226 | T3229 | arg1Of | and,in |
R2769 | T3136 | T3135 | arg2Of | increases,and |
R2770 | T3228 | T3226 | arg2Of | survival,and |
R2771 | T3228 | T3227 | arg1Of | survival,cell |
R2772 | T3136 | T3140 | arg1Of | increases,[ |
R2773 | T3139 | T3136 | arg2Of | binding,increases |
R2774 | T3233 | T3229 | arg2Of | macrophages,in |
R2775 | T3233 | T3230 | arg1Of | macrophages,human |
R2776 | T3233 | T3231 | arg1Of | macrophages,and |
R2777 | T3233 | T3232 | arg1Of | macrophages,mouse |
R2778 | T3235 | T3234 | arg1Of | activity,This |
R2779 | T3235 | T3236 | arg1Of | activity,was |
R2780 | T3235 | T3237 | arg2Of | activity,reduced |
R2781 | T3237 | T3236 | arg2Of | reduced,was |
R2782 | T3139 | T3137 | arg1Of | binding,NF-κB |
R2783 | T3240 | T3242 | arg1Of | conventional,but |
R2784 | T3139 | T3138 | arg1Of | binding,DNA |
R2785 | T3141 | T3140 | arg2Of | 34,[ |
R2786 | T3242 | T3241 | arg1Of | but,"," |
R2787 | T3244 | T3242 | arg2Of | novel,but |
R2788 | T3244 | T3243 | arg1Of | novel,not |
R2789 | T3142 | T3140 | arg3Of | ],[ |
R2790 | T3247 | T3240 | arg1Of | inhibitors,conventional |
R2791 | T3146 | T3147 | arg1Of | PKC,and/or |
R2792 | T3247 | T3244 | arg1Of | inhibitors,novel |
R2793 | T3247 | T3245 | arg1Of | inhibitors,"," |
R2794 | T3247 | T3246 | arg1Of | inhibitors,PKC |
R2795 | T3247 | T3248 | arg1Of | inhibitors,"," |
R2796 | T3248 | T3253 | arg1Of | ",",or |
R2797 | T3147 | T3150 | arg1Of | and/or,is |
R2798 | T3252 | T3248 | arg2Of | constructs,"," |
R2799 | T3252 | T3249 | arg1Of | constructs,dominant |
R2800 | T3252 | T3250 | arg1Of | constructs,negative |
R2801 | T3252 | T3251 | arg1Of | constructs,PKCα |
R2802 | T3253 | T3237 | arg1Of | or,reduced |
R2803 | T3253 | T3238 | arg2Of | or,by |
R2804 | T3253 | T3239 | arg1Of | or,the |
R2805 | T3255 | T3253 | arg2Of | siRNA,or |
R2806 | T3255 | T3254 | arg1Of | siRNA,PKCα |
R2807 | T3147 | T3151 | arg1Of | and/or,critical |
R2808 | T3149 | T3147 | arg2Of | activation,and/or |
R2809 | T3257 | T3256 | arg1Of | PKC,Conventional |
R2810 | T3257 | T3258 | arg1Of | PKC,regulated |
R2811 | T3149 | T3148 | arg1Of | activation,NF-κB |
R2812 | T3261 | T3259 | arg1Of | expression,NF-κB-regulated |
R2813 | T3261 | T3260 | arg1Of | expression,gene |
R2814 | T3261 | T3262 | arg1Of | expression,and |
R2815 | T3262 | T3269 | arg1Of | and,occurred |
R2816 | T3263 | T3262 | arg2Of | phosphorylation,and |
R2817 | T3263 | T3264 | arg1Of | phosphorylation,of |
R2818 | T3150 | T3145 | arg1Of | is,whether |
R2819 | T3265 | T3264 | arg2Of | Ser276,of |
R2820 | T3265 | T3266 | arg1Of | Ser276,of |
R2821 | T3150 | T3159 | arg1Of | is,is |
R2822 | T3268 | T3266 | arg2Of | p65,of |
R2823 | T3268 | T3267 | arg1Of | p65,NF-κB |
R2824 | T3150 | T3160 | arg1Of | is,unclear |
R2825 | T3269 | T3258 | arg2Of | occurred,regulated |
R2826 | T3269 | T3270 | arg1Of | occurred,in |
R2827 | T3151 | T3150 | arg2Of | critical,is |
R2828 | T3273 | T3270 | arg2Of | fashion,in |
R2829 | T3273 | T3271 | arg1Of | fashion,an |
R2830 | T3273 | T3272 | arg1Of | fashion,M-CSF-dependent |
R2831 | T3273 | T3274 | arg1Of | fashion,correlating |
R2832 | T3274 | T3275 | arg1Of | correlating,with |
R2833 | T3151 | T3152 | arg1Of | critical,in |
R2834 | T3156 | T3153 | arg1Of | survival,M-CSF-stimulated |
R2835 | T3279 | T3275 | arg2Of | activity,with |
R2836 | T3279 | T3276 | arg1Of | activity,its |
R2837 | T3279 | T3277 | arg1Of | activity,maximal |
R2838 | T3279 | T3278 | arg1Of | activity,transcriptional |
R2839 | T3283 | T3282 | arg1Of | phosphorylation,PKCα-regulated |
R2840 | T3283 | T3284 | arg1Of | phosphorylation,of |
R2841 | T3283 | T3289 | arg1Of | phosphorylation,plays |
R2842 | T3283 | T3294 | arg1Of | phosphorylation,regulating |
R2843 | T3285 | T3284 | arg2Of | Ser276,of |
R2844 | T3285 | T3286 | arg1Of | Ser276,of |
R2845 | T3156 | T3154 | arg1Of | survival,mononuclear |
R2846 | T3288 | T3286 | arg2Of | p65,of |
R2847 | T3288 | T3287 | arg1Of | p65,NF-κB |
R2848 | T3156 | T3155 | arg1Of | survival,phagocyte |
R2849 | T3289 | T3280 | arg1Of | plays,Furthermore |
R2850 | T3289 | T3281 | arg1Of | plays,"," |
R2851 | T3289 | T3293 | arg1Of | plays,in |
R2852 | T3156 | T3157 | arg1Of | survival,and/or |
R2853 | T3157 | T3152 | arg2Of | and/or,in |
R2854 | T3292 | T3289 | arg2Of | role,plays |
R2855 | T3292 | T3290 | arg1Of | role,an |
R2856 | T3292 | T3291 | arg1Of | role,important |
R2857 | T3294 | T3293 | arg2Of | regulating,in |
R2858 | T3158 | T3157 | arg2Of | differentiation,and/or |
R2859 | T3296 | T3294 | arg2Of | activity,regulating |
R2860 | T3296 | T3295 | arg1Of | activity,its |
R2861 | T3296 | T3297 | arg1Of | activity,in |
R2862 | T3159 | T3143 | arg1Of | is,However |
R2863 | T3299 | T3298 | arg1Of | phagocytes,mononuclear |
R2864 | T3299 | T3300 | arg1Of | phagocytes,and |
R2865 | T3300 | T3297 | arg2Of | and,in |
R2866 | T3159 | T3144 | arg1Of | is,"," |
R2867 | T3160 | T3159 | arg2Of | unclear,is |
R2868 | T3303 | T3300 | arg2Of | fibroblasts,and |
R2869 | T3303 | T3301 | arg1Of | fibroblasts,murine |
R2870 | T3163 | T3161 | arg2Of | cells,In |
R2871 | T3303 | T3302 | arg1Of | fibroblasts,embryonic |
R2872 | T3163 | T3162 | arg1Of | cells,other |
R2873 | T3165 | T3166 | arg1Of | PKC,plays |
R2874 | T3166 | T3161 | arg1Of | plays,In |
R2875 | T3166 | T3164 | arg1Of | plays,"," |
R2876 | T3166 | T3170 | arg1Of | plays,in |
R2877 | T3166 | T3179 | arg1Of | plays,"," |
R2879 | T3169 | T3166 | arg2Of | role,plays |
R2881 | T3169 | T3167 | arg1Of | role,an |
R2882 | T3169 | T3168 | arg1Of | role,important |
R2883 | T3172 | T3171 | arg1Of | activation,NF-κB |
R2884 | T3172 | T3173 | arg1Of | activation,and |
R2885 | T3173 | T3170 | arg2Of | and,in |
R2886 | T3175 | T3173 | arg2Of | survival,and |
R2887 | T3175 | T3174 | arg1Of | survival,cell |
R2888 | T3175 | T3176 | arg1Of | survival,[ |
R2889 | T3177 | T3176 | arg2Of | 35,[ |
R2890 | T3178 | T3176 | arg3Of | ],[ |
R2891 | T3183 | T3181 | arg1Of | mechanisms,the |
R2892 | T3183 | T3182 | arg1Of | mechanisms,specific |
R2893 | T3183 | T3184 | arg1Of | mechanisms,of |
R2894 | T3183 | T3191 | arg1Of | mechanisms,on |
R2895 | T3183 | T3194 | arg1Of | mechanisms,are |
R2896 | T3183 | T3196 | arg2Of | mechanisms,known |
R2897 | T3186 | T3185 | arg1Of | activation,this |
R2898 | T3186 | T3187 | arg1Of | activation,and |
R2899 | T3187 | T3184 | arg2Of | and,of |
R2900 | T3190 | T3187 | arg2Of | effects,and |
R2901 | T3190 | T3188 | arg1Of | effects,the |
R2902 | T3190 | T3189 | arg1Of | effects,biological |
R2903 | T3193 | T3191 | arg2Of | phenotype,on |
R2904 | T3193 | T3192 | arg1Of | phenotype,cellular |
R2905 | T3196 | T3179 | arg2Of | known,"," |
R2906 | T3196 | T3180 | arg1Of | known,however |
R2907 | T3196 | T3194 | arg2Of | known,are |
R2908 | T3196 | T3195 | arg1Of | known,not |
R2909 | T3199 | T3200 | arg1Of | we,focused |
R2910 | T3200 | T3197 | arg1Of | focused,Therefore |
R2911 | T3200 | T3198 | arg1Of | focused,"," |
R2912 | T3200 | T3201 | arg1Of | focused,at |
R2913 | T3202 | T3201 | arg2Of | understanding,at |
R2914 | T3204 | T3202 | arg2Of | role,understanding |
R2915 | T3204 | T3203 | arg1Of | role,the |
R2916 | T3204 | T3205 | arg1Of | role,of |
R2917 | T3204 | T3207 | arg1Of | role,in |
R2918 | T3206 | T3205 | arg2Of | PKC,of |
R2919 | T3209 | T3207 | arg2Of | regulation,in |
R2920 | T3209 | T3208 | arg1Of | regulation,the |
R2921 | T3209 | T3210 | arg1Of | regulation,of |
R2922 | T3212 | T3211 | arg1Of | activation,NF-κB |
R2923 | T3212 | T3213 | arg1Of | activation,and |
R11828 | T15744 | T15745 | arg1Of | important,in |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T968 | 13-98 | Sentence | denotes | Monocytes are produced in the bone marrow and circulate in blood for 24–48 hours [1]. |
T969 | 99-161 | Sentence | denotes | In the absence of serum, monocytes die via apoptosis [1], [2]. |
T970 | 162-273 | Sentence | denotes | Macrophage colony-stimulating factor (M-CSF) stimulates mononuclear phagocyte survival and differentiation [3]. |
T971 | 274-479 | Sentence | denotes | Importantly, M-CSF-mediated cell survival and activation is associated with a variety of human diseases, including atherosclerosis, transplant vascular sclerosis and breast cancer metastasis [4], [5], [6]. |
T972 | 480-579 | Sentence | denotes | We previously identified that NF-κB activation is important in M-CSF-induced monocyte survival [7]. |
T973 | 580-821 | Sentence | denotes | In addition to its role in mononuclear phagocyte survival, the transcription factor NF-κB regulates numerous genes that play important roles in cellular signaling, stress response, cell growth, survival, differentiation and inflammation [8]. |
T974 | 822-865 | Sentence | denotes | There are five members in the NF-κB family: |
T975 | 866-901 | Sentence | denotes | RelA/p65, p50, p52, c-Rel and RelB. |
T976 | 902-1022 | Sentence | denotes | The most common activating complex is the p50/p65 heterodimer, driven by the activation domain in the NF-κB p65 subunit. |
T977 | 1023-1087 | Sentence | denotes | NF-κB p65 regulates important developmental processes [9], [10]. |
T978 | 1088-1183 | Sentence | denotes | Mice lacking NF-κB p65 die in utero and have extensive liver damage via enhanced apoptosis [9]. |
T979 | 1184-1335 | Sentence | denotes | Embryonic macrophages from NF-κB p65 null mice are susceptible to TNFα-induced apoptosis which is rescued by overexpressing the NF-κB p65 subunit [10]. |
T980 | 1336-1505 | Sentence | denotes | Moreover, inhibiting NF-κB induces cell death in many cell types and cytokine-independent survival is mediated by constitutively active NF-κB in murine macrophages [11]. |
T981 | 1506-1641 | Sentence | denotes | In monocytes and macrophages, NF-κB is an important transcriptional factor for expression of cytokines and cell surface receptors [12]. |
T982 | 1642-1851 | Sentence | denotes | However, unlike resting T-cells, NF-κB is constitutively present in the nuclei of primary monocytes and monocytic cell lines in the absence of exogenous stimuli as demonstrated by mobility shift analysis [13]. |
T983 | 1852-1939 | Sentence | denotes | Similarly, constitutively active NF-κB was observed in human alveolar macrophages [14]. |
T984 | 1940-2043 | Sentence | denotes | In the classic/canonical pathway, the NF-κB p50/p65 complex is sequestered in the cytosol by IκBα [15]. |
T985 | 2044-2229 | Sentence | denotes | Upon stimulation by cytokines or UV radiation, IκBα is phosphorylated, ubiquitinated, and degraded, releasing NF-κB p50/p65 to translocate to the nucleus and transactivate target genes. |
T986 | 2230-2344 | Sentence | denotes | After its release from IκBα, NF-κB p65 can undergo post-translational modification to activate gene transcription. |
T987 | 2345-2476 | Sentence | denotes | The role of NF-κB p65 phosphorylation on NF-κB transcriptional activity varies by stimulus, time of stimulation and cell type [16]. |
T988 | 2477-2640 | Sentence | denotes | Previous research shows that phosphorylation of NF-κB p65 at Ser276, Ser529 or Ser536 plays an important role in regulating transcriptional activity of NF-κB [17]. |
T989 | 2641-2770 | Sentence | denotes | In TNFα-treated murine fibroblasts, Ser276 of NF-κB p65 is phosphorylated by MSK1 to enhance NF-κB transcriptional activity [18]. |
T990 | 2771-2976 | Sentence | denotes | In macrophages treated with endotoxin, NF-κB transcription activity is associated with phosphorylation on Ser276 and Ser536 that is regulated through protein kinase A (PKA) and IKKβ respectively[16], [19]. |
T991 | 2977-3130 | Sentence | denotes | In human T cells, NF-κB p65 is constitutively phosphorylated on Ser536 to facilitate NF-κB p65 nuclear translocation following cellular stimulation [20]. |
T992 | 3131-3246 | Sentence | denotes | Accumulating evidence reveals that NF-κB p65 phosphorylation at Ser276 is crucial for its transcriptional activity. |
T993 | 3247-3421 | Sentence | denotes | Upon nuclear translocation, phosphorylation of Ser276 on NF-κB p65 by PKA recruits the transcription co-activator, p300 to potentiate NF-κB-regulated gene transcription [21]. |
T994 | 3422-3531 | Sentence | denotes | However, other studies show that PKA inhibits NF-κB-regulated gene expression by stabilizing IκBα [22], [23]. |
T995 | 3532-3689 | Sentence | denotes | Interestingly, the serine/threonine kinase Pim-1 directly phosphorylates NF-κB p65 at Ser276 by stabilizing to prevent ubiquitin-proteasome degradation [24]. |
T996 | 3690-3788 | Sentence | denotes | Several other phosphorylation sites are also described to enhance NF-κB gene transactivation [25]. |
T997 | 3789-3882 | Sentence | denotes | Here, we investigate the role of protein kinase C (PKC) in M-CSF-stimulated NF-κB activation. |
T998 | 3883-3990 | Sentence | denotes | PKC proteins are multifunctional kinases that differ in structure, function and co-factor requirement [26]. |
T999 | 3991-4106 | Sentence | denotes | PKCs are involved in diverse cell responses, including cell growth, survival, differentiation and development [27]. |
T1000 | 4107-4370 | Sentence | denotes | The 12 closely related enzymes of the PKC family are divided into three classes: conventional (cPKCs: α βI βII and γ require Ca2+ and diacylglycerol (DAG); novel (nPKCs: δ, ε, η, θ and μ) require DAG; and atypical (aPKCs: ξ, ι and λ) require neither Ca2+ nor DAG. |
T1001 | 4371-4500 | Sentence | denotes | Monocytes and macrophages predominantly express conventional PKC isoforms (PKCα PKCβI and PKCβII) and novel PKCs (PKCδ and PKCε). |
T1002 | 4501-4615 | Sentence | denotes | Conventional PKCs regulate differentiation of the human promyelocytic leukemia cell line HL60 to macrophages [28]. |
T1003 | 4616-4711 | Sentence | denotes | PKCα induces IL-1α, iNOS and TNFα mRNA production after lipopolysaccharide (LPS) exposure [29]. |
T1004 | 4712-4819 | Sentence | denotes | In addition, accumulating evidence suggests that conventional PKCs like PKCα have anti-apoptotic functions. |
T1005 | 4820-4929 | Sentence | denotes | For example, PKCα is overexpressed in a variety of tumor cells including gliomas, liver, and lung [30], [31]. |
T1006 | 4930-5008 | Sentence | denotes | In epithelial cells, inhibition of PKCα induces PKCδ-dependent apoptosis [31]. |
T1007 | 5009-5254 | Sentence | denotes | Interestingly, in human monocytes and premonocytic THP-1 leukemia cells, novel PKCs like PKCδ have the opposite effect on cell survival, Voss et al showed that PKCδ directly phosphorylates caspase-3 and promotes etoposide-induced apoptosis [32]. |
T1008 | 5255-5410 | Sentence | denotes | Moreover, knockout mouse studies suggest that another novel PKC, PKCε is critically involved in early LPS-mediated signaling in activated macrophages [33]. |
T1009 | 5411-5525 | Sentence | denotes | Previously, we reported that M-CSF promotes monocyte survival through the activation of the PI3-K/AKT pathway [3]. |
T1010 | 5526-5634 | Sentence | denotes | In addition to AKT activation, M-CSF stimulates PKC in human monocytes and increases NF-κB DNA binding [34]. |
T1011 | 5635-5777 | Sentence | denotes | However, whether PKC and/or NF-κB activation is critical in M-CSF-stimulated mononuclear phagocyte survival and/or differentiation is unclear. |
T1012 | 5778-5980 | Sentence | denotes | In other cells, PKC plays an important role in NF-κB activation and cell survival [35], however the specific mechanisms of this activation and the biological effects on cellular phenotype are not known. |
T1013 | 5981-6110 | Sentence | denotes | Therefore, we focused at understanding the role of PKC in the regulation of NF-κB activation and M-CSF-induced monocyte survival. |
T1014 | 6111-6228 | Sentence | denotes | Here we demonstrates that M-CSF upregulated the NF-κB transcription and cell survival in human and mouse macrophages. |
T1015 | 6229-6355 | Sentence | denotes | This activity was reduced by the conventional, but not novel, PKC inhibitors, dominant negative PKCα constructs or PKCα siRNA. |
T1016 | 6356-6551 | Sentence | denotes | Conventional PKC regulated NF-κB-regulated gene expression and phosphorylation of Ser276 of NF-κB p65 occurred in an M-CSF-dependent fashion correlating with its maximal transcriptional activity. |
T1017 | 6552-6729 | Sentence | denotes | Furthermore, PKCα-regulated phosphorylation of Ser276 of NF-κB p65 plays an important role in regulating its activity in mononuclear phagocytes and murine embryonic fibroblasts. |
T10 | 0-12 | Sentence | denotes | Introduction |
T11 | 13-98 | Sentence | denotes | Monocytes are produced in the bone marrow and circulate in blood for 24–48 hours [1]. |
T12 | 99-161 | Sentence | denotes | In the absence of serum, monocytes die via apoptosis [1], [2]. |
T13 | 162-273 | Sentence | denotes | Macrophage colony-stimulating factor (M-CSF) stimulates mononuclear phagocyte survival and differentiation [3]. |
T14 | 274-479 | Sentence | denotes | Importantly, M-CSF-mediated cell survival and activation is associated with a variety of human diseases, including atherosclerosis, transplant vascular sclerosis and breast cancer metastasis [4], [5], [6]. |
T15 | 480-579 | Sentence | denotes | We previously identified that NF-κB activation is important in M-CSF-induced monocyte survival [7]. |
T16 | 580-821 | Sentence | denotes | In addition to its role in mononuclear phagocyte survival, the transcription factor NF-κB regulates numerous genes that play important roles in cellular signaling, stress response, cell growth, survival, differentiation and inflammation [8]. |
T17 | 822-865 | Sentence | denotes | There are five members in the NF-κB family: |
T18 | 866-901 | Sentence | denotes | RelA/p65, p50, p52, c-Rel and RelB. |
T19 | 902-1022 | Sentence | denotes | The most common activating complex is the p50/p65 heterodimer, driven by the activation domain in the NF-κB p65 subunit. |
T20 | 1023-1087 | Sentence | denotes | NF-κB p65 regulates important developmental processes [9], [10]. |
T21 | 1088-1183 | Sentence | denotes | Mice lacking NF-κB p65 die in utero and have extensive liver damage via enhanced apoptosis [9]. |
T22 | 1184-1335 | Sentence | denotes | Embryonic macrophages from NF-κB p65 null mice are susceptible to TNFα-induced apoptosis which is rescued by overexpressing the NF-κB p65 subunit [10]. |
T23 | 1336-1505 | Sentence | denotes | Moreover, inhibiting NF-κB induces cell death in many cell types and cytokine-independent survival is mediated by constitutively active NF-κB in murine macrophages [11]. |
T24 | 1506-1641 | Sentence | denotes | In monocytes and macrophages, NF-κB is an important transcriptional factor for expression of cytokines and cell surface receptors [12]. |
T25 | 1642-1851 | Sentence | denotes | However, unlike resting T-cells, NF-κB is constitutively present in the nuclei of primary monocytes and monocytic cell lines in the absence of exogenous stimuli as demonstrated by mobility shift analysis [13]. |
T26 | 1852-1939 | Sentence | denotes | Similarly, constitutively active NF-κB was observed in human alveolar macrophages [14]. |
T27 | 1940-2043 | Sentence | denotes | In the classic/canonical pathway, the NF-κB p50/p65 complex is sequestered in the cytosol by IκBα [15]. |
T28 | 2044-2229 | Sentence | denotes | Upon stimulation by cytokines or UV radiation, IκBα is phosphorylated, ubiquitinated, and degraded, releasing NF-κB p50/p65 to translocate to the nucleus and transactivate target genes. |
T29 | 2230-2344 | Sentence | denotes | After its release from IκBα, NF-κB p65 can undergo post-translational modification to activate gene transcription. |
T30 | 2345-2476 | Sentence | denotes | The role of NF-κB p65 phosphorylation on NF-κB transcriptional activity varies by stimulus, time of stimulation and cell type [16]. |
T31 | 2477-2640 | Sentence | denotes | Previous research shows that phosphorylation of NF-κB p65 at Ser276, Ser529 or Ser536 plays an important role in regulating transcriptional activity of NF-κB [17]. |
T32 | 2641-2770 | Sentence | denotes | In TNFα-treated murine fibroblasts, Ser276 of NF-κB p65 is phosphorylated by MSK1 to enhance NF-κB transcriptional activity [18]. |
T33 | 2771-2976 | Sentence | denotes | In macrophages treated with endotoxin, NF-κB transcription activity is associated with phosphorylation on Ser276 and Ser536 that is regulated through protein kinase A (PKA) and IKKβ respectively[16], [19]. |
T34 | 2977-3130 | Sentence | denotes | In human T cells, NF-κB p65 is constitutively phosphorylated on Ser536 to facilitate NF-κB p65 nuclear translocation following cellular stimulation [20]. |
T35 | 3131-3246 | Sentence | denotes | Accumulating evidence reveals that NF-κB p65 phosphorylation at Ser276 is crucial for its transcriptional activity. |
T36 | 3247-3421 | Sentence | denotes | Upon nuclear translocation, phosphorylation of Ser276 on NF-κB p65 by PKA recruits the transcription co-activator, p300 to potentiate NF-κB-regulated gene transcription [21]. |
T37 | 3422-3531 | Sentence | denotes | However, other studies show that PKA inhibits NF-κB-regulated gene expression by stabilizing IκBα [22], [23]. |
T38 | 3532-3689 | Sentence | denotes | Interestingly, the serine/threonine kinase Pim-1 directly phosphorylates NF-κB p65 at Ser276 by stabilizing to prevent ubiquitin-proteasome degradation [24]. |
T39 | 3690-3788 | Sentence | denotes | Several other phosphorylation sites are also described to enhance NF-κB gene transactivation [25]. |
T40 | 3789-3882 | Sentence | denotes | Here, we investigate the role of protein kinase C (PKC) in M-CSF-stimulated NF-κB activation. |
T41 | 3883-3990 | Sentence | denotes | PKC proteins are multifunctional kinases that differ in structure, function and co-factor requirement [26]. |
T42 | 3991-4106 | Sentence | denotes | PKCs are involved in diverse cell responses, including cell growth, survival, differentiation and development [27]. |
T43 | 4107-4370 | Sentence | denotes | The 12 closely related enzymes of the PKC family are divided into three classes: conventional (cPKCs: α βI βII and γ require Ca2+ and diacylglycerol (DAG); novel (nPKCs: δ, ε, η, θ and μ) require DAG; and atypical (aPKCs: ξ, ι and λ) require neither Ca2+ nor DAG. |
T44 | 4371-4500 | Sentence | denotes | Monocytes and macrophages predominantly express conventional PKC isoforms (PKCα PKCβI and PKCβII) and novel PKCs (PKCδ and PKCε). |
T45 | 4501-4615 | Sentence | denotes | Conventional PKCs regulate differentiation of the human promyelocytic leukemia cell line HL60 to macrophages [28]. |
T46 | 4616-4711 | Sentence | denotes | PKCα induces IL-1α, iNOS and TNFα mRNA production after lipopolysaccharide (LPS) exposure [29]. |
T47 | 4712-4819 | Sentence | denotes | In addition, accumulating evidence suggests that conventional PKCs like PKCα have anti-apoptotic functions. |
T48 | 4820-4929 | Sentence | denotes | For example, PKCα is overexpressed in a variety of tumor cells including gliomas, liver, and lung [30], [31]. |
T49 | 4930-5008 | Sentence | denotes | In epithelial cells, inhibition of PKCα induces PKCδ-dependent apoptosis [31]. |
T50 | 5009-5254 | Sentence | denotes | Interestingly, in human monocytes and premonocytic THP-1 leukemia cells, novel PKCs like PKCδ have the opposite effect on cell survival, Voss et al showed that PKCδ directly phosphorylates caspase-3 and promotes etoposide-induced apoptosis [32]. |
T51 | 5255-5410 | Sentence | denotes | Moreover, knockout mouse studies suggest that another novel PKC, PKCε is critically involved in early LPS-mediated signaling in activated macrophages [33]. |
T52 | 5411-5525 | Sentence | denotes | Previously, we reported that M-CSF promotes monocyte survival through the activation of the PI3-K/AKT pathway [3]. |
T53 | 5526-5634 | Sentence | denotes | In addition to AKT activation, M-CSF stimulates PKC in human monocytes and increases NF-κB DNA binding [34]. |
T54 | 5635-5777 | Sentence | denotes | However, whether PKC and/or NF-κB activation is critical in M-CSF-stimulated mononuclear phagocyte survival and/or differentiation is unclear. |
T55 | 5778-5980 | Sentence | denotes | In other cells, PKC plays an important role in NF-κB activation and cell survival [35], however the specific mechanisms of this activation and the biological effects on cellular phenotype are not known. |
T56 | 5981-6110 | Sentence | denotes | Therefore, we focused at understanding the role of PKC in the regulation of NF-κB activation and M-CSF-induced monocyte survival. |
T57 | 6111-6228 | Sentence | denotes | Here we demonstrates that M-CSF upregulated the NF-κB transcription and cell survival in human and mouse macrophages. |
T58 | 6229-6355 | Sentence | denotes | This activity was reduced by the conventional, but not novel, PKC inhibitors, dominant negative PKCα constructs or PKCα siRNA. |
T59 | 6356-6551 | Sentence | denotes | Conventional PKC regulated NF-κB-regulated gene expression and phosphorylation of Ser276 of NF-κB p65 occurred in an M-CSF-dependent fashion correlating with its maximal transcriptional activity. |
T60 | 6552-6729 | Sentence | denotes | Furthermore, PKCα-regulated phosphorylation of Ser276 of NF-κB p65 plays an important role in regulating its activity in mononuclear phagocytes and murine embryonic fibroblasts. |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
22216091-355567-90609669 | 95-96 | 355567 | denotes | 1 |
22216091-355567-90609670 | 153-154 | 355567 | denotes | 1 |
22216091-1940344-90609671 | 158-159 | 1940344 | denotes | 2 |
22216091-10473597-90609672 | 270-271 | 10473597 | denotes | 3 |
22216091-15289345-90609673 | 466-467 | 15289345 | denotes | 4 |
22216091-8633015-90609674 | 471-472 | 8633015 | denotes | 5 |
22216091-7667279-90609675 | 476-477 | 7667279 | denotes | 6 |
22216091-11804874-90609676 | 576-577 | 11804874 | denotes | 7 |
22216091-12464174-90609677 | 818-819 | 12464174 | denotes | 8 |
22216091-15897281-90609678 | 1078-1079 | 15897281 | denotes | 9 |
22216091-9299587-90609679 | 1083-1085 | 9299587 | denotes | 10 |
22216091-15897281-90609680 | 1180-1181 | 15897281 | denotes | 9 |
22216091-9299587-90609681 | 1331-1333 | 9299587 | denotes | 10 |
22216091-11073986-90609682 | 1501-1503 | 11073986 | denotes | 11 |
22216091-8717528-90609683 | 1637-1639 | 8717528 | denotes | 12 |
22216091-7998962-90609684 | 1847-1849 | 7998962 | denotes | 13 |
22216091-9878123-90609685 | 1935-1937 | 9878123 | denotes | 14 |
22216091-17072321-90609686 | 2039-2041 | 17072321 | denotes | 15 |
22216091-9150141-90609687 | 2472-2474 | 9150141 | denotes | 16 |
22216091-15122352-90609688 | 2636-2638 | 15122352 | denotes | 17 |
22216091-12628924-90609689 | 2766-2768 | 12628924 | denotes | 18 |
22216091-9150141-90609690 | 2966-2968 | 9150141 | denotes | 16 |
22216091-17405917-90609691 | 2972-2974 | 17405917 | denotes | 19 |
22216091-16105840-90609692 | 3126-3128 | 16105840 | denotes | 20 |
22216091-11931769-90609693 | 3417-3419 | 11931769 | denotes | 21 |
22216091-7744006-90609694 | 3521-3523 | 7744006 | denotes | 22 |
22216091-19911008-90609695 | 3685-3687 | 19911008 | denotes | 24 |
22216091-11983155-90609696 | 3784-3786 | 11983155 | denotes | 25 |
22216091-12495431-90609697 | 3986-3988 | 12495431 | denotes | 26 |
22216091-17922632-90609698 | 4102-4104 | 17922632 | denotes | 27 |
22216091-9369943-90609699 | 4611-4613 | 9369943 | denotes | 28 |
22216091-9830023-90609700 | 4707-4709 | 9830023 | denotes | 29 |
22216091-17582782-90609701 | 4919-4921 | 17582782 | denotes | 30 |
22216091-12700627-90609702 | 4925-4927 | 12700627 | denotes | 31 |
22216091-12700627-90609703 | 5004-5006 | 12700627 | denotes | 31 |
22216091-15716280-90609704 | 5250-5252 | 15716280 | denotes | 32 |
22216091-11696589-90609705 | 5406-5408 | 11696589 | denotes | 33 |
22216091-10473597-90609706 | 5522-5523 | 10473597 | denotes | 3 |
22216091-1883525-90609707 | 5630-5632 | 1883525 | denotes | 34 |
22216091-19273207-90609708 | 5861-5863 | 19273207 | denotes | 35 |
bionlp-st-ge-2016-spacy-parsed
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1018 | 13-22 | NNS | denotes | Monocytes |
T1019 | 23-26 | VBP | denotes | are |
T1020 | 27-35 | VBN | denotes | produced |
T1021 | 36-38 | IN | denotes | in |
T1022 | 39-42 | DT | denotes | the |
T1023 | 43-47 | NN | denotes | bone |
T1024 | 48-54 | NN | denotes | marrow |
T1025 | 55-58 | CC | denotes | and |
T1026 | 59-68 | VBP | denotes | circulate |
T1027 | 69-71 | IN | denotes | in |
T1028 | 72-77 | NN | denotes | blood |
T1029 | 78-81 | IN | denotes | for |
T1030 | 82-84 | CD | denotes | 24 |
T1031 | 85-87 | CD | denotes | 48 |
T1032 | 88-93 | NNS | denotes | hours |
T1033 | 94-95 | NNP | denotes | [ |
T1034 | 95-96 | CD | denotes | 1 |
T1035 | 96-97 | NNP | denotes | ] |
T1036 | 97-98 | . | denotes | . |
T1037 | 99-101 | IN | denotes | In |
T1038 | 102-105 | DT | denotes | the |
T1039 | 106-113 | NN | denotes | absence |
T1040 | 114-116 | IN | denotes | of |
T1041 | 117-122 | NN | denotes | serum |
T1042 | 122-123 | , | denotes | , |
T1043 | 124-133 | NNS | denotes | monocytes |
T1044 | 134-137 | VBP | denotes | die |
T1045 | 138-141 | IN | denotes | via |
T1046 | 142-151 | NN | denotes | apoptosis |
T1047 | 152-153 | NN | denotes | [ |
T1048 | 153-154 | CD | denotes | 1 |
T1049 | 154-155 | NNP | denotes | ] |
T1050 | 155-156 | , | denotes | , |
T1051 | 157-158 | NNP | denotes | [ |
T1052 | 158-159 | CD | denotes | 2 |
T1053 | 159-160 | NNP | denotes | ] |
T1054 | 160-161 | . | denotes | . |
T1055 | 162-172 | NNP | denotes | Macrophage |
T1056 | 173-191 | JJ | denotes | colony-stimulating |
T1057 | 192-198 | NN | denotes | factor |
T1058 | 199-200 | -LRB- | denotes | ( |
T1059 | 200-205 | NNP | denotes | M-CSF |
T1060 | 205-206 | -RRB- | denotes | ) |
T1061 | 207-217 | VBZ | denotes | stimulates |
T1062 | 218-229 | JJ | denotes | mononuclear |
T1063 | 230-239 | JJ | denotes | phagocyte |
T1064 | 240-248 | NN | denotes | survival |
T1065 | 249-252 | CC | denotes | and |
T1066 | 253-268 | NN | denotes | differentiation |
T1067 | 269-270 | NN | denotes | [ |
T1068 | 270-271 | CD | denotes | 3 |
T1069 | 271-272 | NNP | denotes | ] |
T1070 | 272-273 | . | denotes | . |
T1071 | 274-285 | RB | denotes | Importantly |
T1072 | 285-286 | , | denotes | , |
T1073 | 287-301 | JJ | denotes | M-CSF-mediated |
T1074 | 302-306 | NN | denotes | cell |
T1075 | 307-315 | NN | denotes | survival |
T1076 | 316-319 | CC | denotes | and |
T1077 | 320-330 | NN | denotes | activation |
T1078 | 331-333 | VBZ | denotes | is |
T1079 | 334-344 | VBN | denotes | associated |
T1080 | 345-349 | IN | denotes | with |
T1081 | 350-351 | DT | denotes | a |
T1082 | 352-359 | NN | denotes | variety |
T1083 | 360-362 | IN | denotes | of |
T1084 | 363-368 | JJ | denotes | human |
T1085 | 369-377 | NNS | denotes | diseases |
T1086 | 377-378 | , | denotes | , |
T1087 | 379-388 | VBG | denotes | including |
T1088 | 389-404 | NN | denotes | atherosclerosis |
T1089 | 404-405 | , | denotes | , |
T1090 | 406-416 | NN | denotes | transplant |
T1091 | 417-425 | JJ | denotes | vascular |
T1092 | 426-435 | NN | denotes | sclerosis |
T1093 | 436-439 | CC | denotes | and |
T1094 | 440-446 | NN | denotes | breast |
T1095 | 447-453 | NN | denotes | cancer |
T1096 | 454-464 | NN | denotes | metastasis |
T1097 | 465-466 | NNP | denotes | [ |
T1098 | 466-467 | CD | denotes | 4 |
T1099 | 467-468 | NNP | denotes | ] |
T1100 | 468-469 | , | denotes | , |
T1101 | 470-471 | NNP | denotes | [ |
T1102 | 471-472 | CD | denotes | 5 |
T1103 | 472-473 | NNP | denotes | ] |
T1104 | 473-474 | , | denotes | , |
T1105 | 475-476 | NNP | denotes | [ |
T1106 | 476-477 | CD | denotes | 6 |
T1107 | 477-478 | NNP | denotes | ] |
T1108 | 478-479 | . | denotes | . |
T1109 | 480-482 | PRP | denotes | We |
T1110 | 483-493 | RB | denotes | previously |
T1111 | 494-504 | VBD | denotes | identified |
T1112 | 505-509 | IN | denotes | that |
T1113 | 510-515 | JJ | denotes | NF-κB |
T1114 | 516-526 | NN | denotes | activation |
T1115 | 527-529 | VBZ | denotes | is |
T1116 | 530-539 | JJ | denotes | important |
T1117 | 540-542 | IN | denotes | in |
T1118 | 543-556 | JJ | denotes | M-CSF-induced |
T1119 | 557-565 | NN | denotes | monocyte |
T1120 | 566-574 | NN | denotes | survival |
T1121 | 575-576 | NN | denotes | [ |
T1122 | 576-577 | CD | denotes | 7 |
T1123 | 577-578 | NNP | denotes | ] |
T1124 | 578-579 | . | denotes | . |
T1125 | 580-582 | IN | denotes | In |
T1126 | 583-591 | NN | denotes | addition |
T1127 | 592-594 | TO | denotes | to |
T1128 | 595-598 | PRP$ | denotes | its |
T1129 | 599-603 | NN | denotes | role |
T1130 | 604-606 | IN | denotes | in |
T1131 | 607-618 | NN | denotes | mononuclear |
T1132 | 619-628 | JJ | denotes | phagocyte |
T1133 | 629-637 | NN | denotes | survival |
T1134 | 637-638 | , | denotes | , |
T1135 | 639-642 | DT | denotes | the |
T1136 | 643-656 | NN | denotes | transcription |
T1137 | 657-663 | NN | denotes | factor |
T1138 | 664-669 | NNP | denotes | NF-κB |
T1139 | 670-679 | VBZ | denotes | regulates |
T1140 | 680-688 | JJ | denotes | numerous |
T1141 | 689-694 | NNS | denotes | genes |
T1142 | 695-699 | WDT | denotes | that |
T1143 | 700-704 | VBP | denotes | play |
T1144 | 705-714 | JJ | denotes | important |
T1145 | 715-720 | NNS | denotes | roles |
T1146 | 721-723 | IN | denotes | in |
T1147 | 724-732 | JJ | denotes | cellular |
T1148 | 733-742 | VBG | denotes | signaling |
T1149 | 742-743 | , | denotes | , |
T1150 | 744-750 | NN | denotes | stress |
T1151 | 751-759 | NN | denotes | response |
T1152 | 759-760 | , | denotes | , |
T1153 | 761-765 | NN | denotes | cell |
T1154 | 766-772 | NN | denotes | growth |
T1155 | 772-773 | , | denotes | , |
T1156 | 774-782 | NN | denotes | survival |
T1157 | 782-783 | , | denotes | , |
T1158 | 784-799 | NN | denotes | differentiation |
T1159 | 800-803 | CC | denotes | and |
T1160 | 804-816 | NN | denotes | inflammation |
T1161 | 817-818 | NN | denotes | [ |
T1162 | 818-819 | CD | denotes | 8 |
T1163 | 819-820 | NNP | denotes | ] |
T1164 | 820-821 | . | denotes | . |
T1165 | 822-827 | EX | denotes | There |
T1166 | 828-831 | VBP | denotes | are |
T1167 | 832-836 | CD | denotes | five |
T1168 | 837-844 | NNS | denotes | members |
T1169 | 845-847 | IN | denotes | in |
T1170 | 848-851 | DT | denotes | the |
T1171 | 852-857 | NNP | denotes | NF-κB |
T1172 | 858-864 | NN | denotes | family |
T1173 | 864-865 | : | denotes | : |
T1174 | 866-874 | NNS | denotes | RelA/p65 |
T1175 | 874-875 | , | denotes | , |
T1176 | 876-879 | CD | denotes | p50 |
T1177 | 879-880 | , | denotes | , |
T1178 | 881-884 | CD | denotes | p52 |
T1179 | 884-885 | , | denotes | , |
T1180 | 886-891 | NNP | denotes | c-Rel |
T1181 | 892-895 | CC | denotes | and |
T1182 | 896-900 | NNP | denotes | RelB |
T1183 | 900-901 | . | denotes | . |
T1184 | 902-905 | DT | denotes | The |
T1185 | 906-910 | RBS | denotes | most |
T1186 | 911-917 | JJ | denotes | common |
T1187 | 918-928 | NN | denotes | activating |
T1188 | 929-936 | NN | denotes | complex |
T1189 | 937-939 | VBZ | denotes | is |
T1190 | 940-943 | DT | denotes | the |
T1191 | 944-951 | CD | denotes | p50/p65 |
T1192 | 952-963 | NN | denotes | heterodimer |
T1193 | 963-964 | , | denotes | , |
T1194 | 965-971 | VBN | denotes | driven |
T1195 | 972-974 | IN | denotes | by |
T1196 | 975-978 | DT | denotes | the |
T1197 | 979-989 | NN | denotes | activation |
T1198 | 990-996 | NN | denotes | domain |
T1199 | 997-999 | IN | denotes | in |
T1200 | 1000-1003 | DT | denotes | the |
T1201 | 1004-1009 | NNP | denotes | NF-κB |
T1202 | 1010-1013 | CD | denotes | p65 |
T1203 | 1014-1021 | NN | denotes | subunit |
T1204 | 1021-1022 | . | denotes | . |
T1205 | 1023-1028 | NNP | denotes | NF-κB |
T1206 | 1029-1032 | CD | denotes | p65 |
T1207 | 1033-1042 | VBZ | denotes | regulates |
T1208 | 1043-1052 | JJ | denotes | important |
T1209 | 1053-1066 | JJ | denotes | developmental |
T1210 | 1067-1076 | NNS | denotes | processes |
T1211 | 1077-1078 | VBP | denotes | [ |
T1212 | 1078-1079 | CD | denotes | 9 |
T1213 | 1079-1080 | NNP | denotes | ] |
T1214 | 1080-1081 | , | denotes | , |
T1215 | 1082-1083 | NNP | denotes | [ |
T1216 | 1083-1085 | CD | denotes | 10 |
T1217 | 1085-1086 | NNP | denotes | ] |
T1218 | 1086-1087 | . | denotes | . |
T1219 | 1088-1092 | NNP | denotes | Mice |
T1220 | 1093-1100 | VBG | denotes | lacking |
T1221 | 1101-1106 | NNP | denotes | NF-κB |
T1222 | 1107-1110 | CD | denotes | p65 |
T1223 | 1111-1114 | NN | denotes | die |
T1224 | 1115-1117 | IN | denotes | in |
T1225 | 1118-1123 | NN | denotes | utero |
T1226 | 1124-1127 | CC | denotes | and |
T1227 | 1128-1132 | VBP | denotes | have |
T1228 | 1133-1142 | JJ | denotes | extensive |
T1229 | 1143-1148 | NN | denotes | liver |
T1230 | 1149-1155 | NN | denotes | damage |
T1231 | 1156-1159 | IN | denotes | via |
T1232 | 1160-1168 | JJ | denotes | enhanced |
T1233 | 1169-1178 | NN | denotes | apoptosis |
T1234 | 1179-1180 | NN | denotes | [ |
T1235 | 1180-1181 | CD | denotes | 9 |
T1236 | 1181-1182 | NNP | denotes | ] |
T1237 | 1182-1183 | . | denotes | . |
T1238 | 1184-1193 | JJ | denotes | Embryonic |
T1239 | 1194-1205 | NNS | denotes | macrophages |
T1240 | 1206-1210 | IN | denotes | from |
T1241 | 1211-1216 | NNP | denotes | NF-κB |
T1242 | 1217-1220 | CD | denotes | p65 |
T1243 | 1221-1225 | NN | denotes | null |
T1244 | 1226-1230 | NNS | denotes | mice |
T1245 | 1231-1234 | VBP | denotes | are |
T1246 | 1235-1246 | JJ | denotes | susceptible |
T1247 | 1247-1249 | TO | denotes | to |
T1248 | 1250-1262 | JJ | denotes | TNFα-induced |
T1249 | 1263-1272 | NN | denotes | apoptosis |
T1250 | 1273-1278 | WDT | denotes | which |
T1251 | 1279-1281 | VBZ | denotes | is |
T1252 | 1282-1289 | VBN | denotes | rescued |
T1253 | 1290-1292 | IN | denotes | by |
T1254 | 1293-1307 | VBG | denotes | overexpressing |
T1255 | 1308-1311 | DT | denotes | the |
T1256 | 1312-1317 | NNP | denotes | NF-κB |
T1257 | 1318-1321 | CD | denotes | p65 |
T1258 | 1322-1329 | VBN | denotes | subunit |
T1259 | 1330-1331 | NNP | denotes | [ |
T1260 | 1331-1333 | CD | denotes | 10 |
T1261 | 1333-1334 | NNP | denotes | ] |
T1262 | 1334-1335 | . | denotes | . |
T1263 | 1336-1344 | RB | denotes | Moreover |
T1264 | 1344-1345 | , | denotes | , |
T1265 | 1346-1356 | VBG | denotes | inhibiting |
T1266 | 1357-1362 | JJ | denotes | NF-κB |
T1267 | 1363-1370 | VBZ | denotes | induces |
T1268 | 1371-1375 | NN | denotes | cell |
T1269 | 1376-1381 | NN | denotes | death |
T1270 | 1382-1384 | IN | denotes | in |
T1271 | 1385-1389 | JJ | denotes | many |
T1272 | 1390-1394 | NN | denotes | cell |
T1273 | 1395-1400 | NNS | denotes | types |
T1274 | 1401-1404 | CC | denotes | and |
T1275 | 1405-1425 | JJ | denotes | cytokine-independent |
T1276 | 1426-1434 | NN | denotes | survival |
T1277 | 1435-1437 | VBZ | denotes | is |
T1278 | 1438-1446 | VBN | denotes | mediated |
T1279 | 1447-1449 | IN | denotes | by |
T1280 | 1450-1464 | RB | denotes | constitutively |
T1281 | 1465-1471 | JJ | denotes | active |
T1282 | 1472-1477 | NN | denotes | NF-κB |
T1283 | 1478-1480 | IN | denotes | in |
T1284 | 1481-1487 | JJ | denotes | murine |
T1285 | 1488-1499 | NNS | denotes | macrophages |
T1286 | 1500-1501 | NNP | denotes | [ |
T1287 | 1501-1503 | CD | denotes | 11 |
T1288 | 1503-1504 | NNP | denotes | ] |
T1289 | 1504-1505 | . | denotes | . |
T1290 | 1506-1508 | IN | denotes | In |
T1291 | 1509-1518 | NNS | denotes | monocytes |
T1292 | 1519-1522 | CC | denotes | and |
T1293 | 1523-1534 | NNS | denotes | macrophages |
T1294 | 1534-1535 | , | denotes | , |
T1295 | 1536-1541 | NN | denotes | NF-κB |
T1296 | 1542-1544 | VBZ | denotes | is |
T1297 | 1545-1547 | DT | denotes | an |
T1298 | 1548-1557 | JJ | denotes | important |
T1299 | 1558-1573 | JJ | denotes | transcriptional |
T1300 | 1574-1580 | NN | denotes | factor |
T1301 | 1581-1584 | IN | denotes | for |
T1302 | 1585-1595 | NN | denotes | expression |
T1303 | 1596-1598 | IN | denotes | of |
T1304 | 1599-1608 | NNS | denotes | cytokines |
T1305 | 1609-1612 | CC | denotes | and |
T1306 | 1613-1617 | NN | denotes | cell |
T1307 | 1618-1625 | NN | denotes | surface |
T1308 | 1626-1635 | NNS | denotes | receptors |
T1309 | 1636-1637 | NNP | denotes | [ |
T1310 | 1637-1639 | CD | denotes | 12 |
T1311 | 1639-1640 | NNP | denotes | ] |
T1312 | 1640-1641 | . | denotes | . |
T1313 | 1642-1649 | RB | denotes | However |
T1314 | 1649-1650 | , | denotes | , |
T1315 | 1651-1657 | IN | denotes | unlike |
T1316 | 1658-1665 | VBG | denotes | resting |
T1317 | 1666-1673 | NNS | denotes | T-cells |
T1318 | 1673-1674 | , | denotes | , |
T1319 | 1675-1680 | NN | denotes | NF-κB |
T1320 | 1681-1683 | VBZ | denotes | is |
T1321 | 1684-1698 | RB | denotes | constitutively |
T1322 | 1699-1706 | JJ | denotes | present |
T1323 | 1707-1709 | IN | denotes | in |
T1324 | 1710-1713 | DT | denotes | the |
T1325 | 1714-1720 | NN | denotes | nuclei |
T1326 | 1721-1723 | IN | denotes | of |
T1327 | 1724-1731 | JJ | denotes | primary |
T1328 | 1732-1741 | NNS | denotes | monocytes |
T1329 | 1742-1745 | CC | denotes | and |
T1330 | 1746-1755 | JJ | denotes | monocytic |
T1331 | 1756-1760 | NN | denotes | cell |
T1332 | 1761-1766 | NNS | denotes | lines |
T1333 | 1767-1769 | IN | denotes | in |
T1334 | 1770-1773 | DT | denotes | the |
T1335 | 1774-1781 | NN | denotes | absence |
T1336 | 1782-1784 | IN | denotes | of |
T1337 | 1785-1794 | JJ | denotes | exogenous |
T1338 | 1795-1802 | NNS | denotes | stimuli |
T1339 | 1803-1805 | IN | denotes | as |
T1340 | 1806-1818 | VBN | denotes | demonstrated |
T1341 | 1819-1821 | IN | denotes | by |
T1342 | 1822-1830 | NN | denotes | mobility |
T1343 | 1831-1836 | NN | denotes | shift |
T1344 | 1837-1845 | NN | denotes | analysis |
T1345 | 1846-1847 | NNP | denotes | [ |
T1346 | 1847-1849 | CD | denotes | 13 |
T1347 | 1849-1850 | NNP | denotes | ] |
T1348 | 1850-1851 | . | denotes | . |
T1349 | 1852-1861 | RB | denotes | Similarly |
T1350 | 1861-1862 | , | denotes | , |
T1351 | 1863-1877 | RB | denotes | constitutively |
T1352 | 1878-1884 | JJ | denotes | active |
T1353 | 1885-1890 | NN | denotes | NF-κB |
T1354 | 1891-1894 | VBD | denotes | was |
T1355 | 1895-1903 | VBN | denotes | observed |
T1356 | 1904-1906 | IN | denotes | in |
T1357 | 1907-1912 | JJ | denotes | human |
T1358 | 1913-1921 | JJ | denotes | alveolar |
T1359 | 1922-1933 | NNS | denotes | macrophages |
T1360 | 1934-1935 | NNP | denotes | [ |
T1361 | 1935-1937 | CD | denotes | 14 |
T1362 | 1937-1938 | NNP | denotes | ] |
T1363 | 1938-1939 | . | denotes | . |
T1364 | 1940-1942 | IN | denotes | In |
T1365 | 1943-1946 | DT | denotes | the |
T1366 | 1947-1964 | JJ | denotes | classic/canonical |
T1367 | 1965-1972 | NN | denotes | pathway |
T1368 | 1972-1973 | , | denotes | , |
T1369 | 1974-1977 | DT | denotes | the |
T1370 | 1978-1983 | NNP | denotes | NF-κB |
T1371 | 1984-1991 | CD | denotes | p50/p65 |
T1372 | 1992-1999 | NN | denotes | complex |
T1373 | 2000-2002 | VBZ | denotes | is |
T1374 | 2003-2014 | VBN | denotes | sequestered |
T1375 | 2015-2017 | IN | denotes | in |
T1376 | 2018-2021 | DT | denotes | the |
T1377 | 2022-2029 | NN | denotes | cytosol |
T1378 | 2030-2032 | IN | denotes | by |
T1379 | 2033-2037 | NNP | denotes | IκBα |
T1380 | 2038-2039 | NNP | denotes | [ |
T1381 | 2039-2041 | CD | denotes | 15 |
T1382 | 2041-2042 | NNP | denotes | ] |
T1383 | 2042-2043 | . | denotes | . |
T1384 | 2044-2048 | IN | denotes | Upon |
T1385 | 2049-2060 | NN | denotes | stimulation |
T1386 | 2061-2063 | IN | denotes | by |
T1387 | 2064-2073 | NNS | denotes | cytokines |
T1388 | 2074-2076 | CC | denotes | or |
T1389 | 2077-2079 | NN | denotes | UV |
T1390 | 2080-2089 | NN | denotes | radiation |
T1391 | 2089-2090 | , | denotes | , |
T1392 | 2091-2095 | NNP | denotes | IκBα |
T1393 | 2096-2098 | VBZ | denotes | is |
T1394 | 2099-2113 | VBN | denotes | phosphorylated |
T1395 | 2113-2114 | , | denotes | , |
T1396 | 2115-2128 | VBN | denotes | ubiquitinated |
T1397 | 2128-2129 | , | denotes | , |
T1398 | 2130-2133 | CC | denotes | and |
T1399 | 2134-2142 | JJ | denotes | degraded |
T1400 | 2142-2143 | , | denotes | , |
T1401 | 2144-2153 | VBG | denotes | releasing |
T1402 | 2154-2159 | NNP | denotes | NF-κB |
T1403 | 2160-2167 | CD | denotes | p50/p65 |
T1404 | 2168-2170 | TO | denotes | to |
T1405 | 2171-2182 | VB | denotes | translocate |
T1406 | 2183-2185 | TO | denotes | to |
T1407 | 2186-2189 | DT | denotes | the |
T1408 | 2190-2197 | NN | denotes | nucleus |
T1409 | 2198-2201 | CC | denotes | and |
T1410 | 2202-2215 | NN | denotes | transactivate |
T1411 | 2216-2222 | NN | denotes | target |
T1412 | 2223-2228 | NNS | denotes | genes |
T1413 | 2228-2229 | . | denotes | . |
T1414 | 2230-2235 | IN | denotes | After |
T1415 | 2236-2239 | PRP$ | denotes | its |
T1416 | 2240-2247 | NN | denotes | release |
T1417 | 2248-2252 | IN | denotes | from |
T1418 | 2253-2257 | NNP | denotes | IκBα |
T1419 | 2257-2258 | , | denotes | , |
T1420 | 2259-2264 | NNP | denotes | NF-κB |
T1421 | 2265-2268 | NNS | denotes | p65 |
T1422 | 2269-2272 | MD | denotes | can |
T1423 | 2273-2280 | VB | denotes | undergo |
T1424 | 2281-2299 | JJ | denotes | post-translational |
T1425 | 2300-2312 | NN | denotes | modification |
T1426 | 2313-2315 | TO | denotes | to |
T1427 | 2316-2324 | VB | denotes | activate |
T1428 | 2325-2329 | NN | denotes | gene |
T1429 | 2330-2343 | NN | denotes | transcription |
T1430 | 2343-2344 | . | denotes | . |
T1431 | 2345-2348 | DT | denotes | The |
T1432 | 2349-2353 | NN | denotes | role |
T1433 | 2354-2356 | IN | denotes | of |
T1434 | 2357-2362 | NNP | denotes | NF-κB |
T1435 | 2363-2366 | CD | denotes | p65 |
T1436 | 2367-2382 | NN | denotes | phosphorylation |
T1437 | 2383-2385 | IN | denotes | on |
T1438 | 2386-2391 | JJ | denotes | NF-κB |
T1439 | 2392-2407 | JJ | denotes | transcriptional |
T1440 | 2408-2416 | NN | denotes | activity |
T1441 | 2417-2423 | VBZ | denotes | varies |
T1442 | 2424-2426 | IN | denotes | by |
T1443 | 2427-2435 | NN | denotes | stimulus |
T1444 | 2435-2436 | , | denotes | , |
T1445 | 2437-2441 | NN | denotes | time |
T1446 | 2442-2444 | IN | denotes | of |
T1447 | 2445-2456 | NN | denotes | stimulation |
T1448 | 2457-2460 | CC | denotes | and |
T1449 | 2461-2465 | NN | denotes | cell |
T1450 | 2466-2470 | NN | denotes | type |
T1451 | 2471-2472 | NNP | denotes | [ |
T1452 | 2472-2474 | CD | denotes | 16 |
T1453 | 2474-2475 | NNP | denotes | ] |
T1454 | 2475-2476 | . | denotes | . |
T1455 | 2477-2485 | JJ | denotes | Previous |
T1456 | 2486-2494 | NN | denotes | research |
T1457 | 2495-2500 | VBZ | denotes | shows |
T1458 | 2501-2505 | IN | denotes | that |
T1459 | 2506-2521 | NN | denotes | phosphorylation |
T1460 | 2522-2524 | IN | denotes | of |
T1461 | 2525-2530 | NNP | denotes | NF-κB |
T1462 | 2531-2534 | NNS | denotes | p65 |
T1463 | 2535-2537 | IN | denotes | at |
T1464 | 2538-2544 | NNP | denotes | Ser276 |
T1465 | 2544-2545 | , | denotes | , |
T1466 | 2546-2552 | NNP | denotes | Ser529 |
T1467 | 2553-2555 | CC | denotes | or |
T1468 | 2556-2562 | NNP | denotes | Ser536 |
T1469 | 2563-2568 | VBZ | denotes | plays |
T1470 | 2569-2571 | DT | denotes | an |
T1471 | 2572-2581 | JJ | denotes | important |
T1472 | 2582-2586 | NN | denotes | role |
T1473 | 2587-2589 | IN | denotes | in |
T1474 | 2590-2600 | VBG | denotes | regulating |
T1475 | 2601-2616 | JJ | denotes | transcriptional |
T1476 | 2617-2625 | NN | denotes | activity |
T1477 | 2626-2628 | IN | denotes | of |
T1478 | 2629-2634 | NNP | denotes | NF-κB |
T1479 | 2635-2636 | NNP | denotes | [ |
T1480 | 2636-2638 | CD | denotes | 17 |
T1481 | 2638-2639 | NNP | denotes | ] |
T1482 | 2639-2640 | . | denotes | . |
T1483 | 2641-2643 | IN | denotes | In |
T1484 | 2644-2656 | JJ | denotes | TNFα-treated |
T1485 | 2657-2663 | NN | denotes | murine |
T1486 | 2664-2675 | NNS | denotes | fibroblasts |
T1487 | 2675-2676 | , | denotes | , |
T1488 | 2677-2683 | NNP | denotes | Ser276 |
T1489 | 2684-2686 | IN | denotes | of |
T1490 | 2687-2692 | NNP | denotes | NF-κB |
T1491 | 2693-2696 | CD | denotes | p65 |
T1492 | 2697-2699 | VBZ | denotes | is |
T1493 | 2700-2714 | VBN | denotes | phosphorylated |
T1494 | 2715-2717 | IN | denotes | by |
T1495 | 2718-2722 | CD | denotes | MSK1 |
T1496 | 2723-2725 | TO | denotes | to |
T1497 | 2726-2733 | VB | denotes | enhance |
T1498 | 2734-2739 | JJ | denotes | NF-κB |
T1499 | 2740-2755 | JJ | denotes | transcriptional |
T1500 | 2756-2764 | NN | denotes | activity |
T1501 | 2765-2766 | NNP | denotes | [ |
T1502 | 2766-2768 | CD | denotes | 18 |
T1503 | 2768-2769 | NNP | denotes | ] |
T1504 | 2769-2770 | . | denotes | . |
T1505 | 2771-2773 | IN | denotes | In |
T1506 | 2774-2785 | NNS | denotes | macrophages |
T1507 | 2786-2793 | VBN | denotes | treated |
T1508 | 2794-2798 | IN | denotes | with |
T1509 | 2799-2808 | NN | denotes | endotoxin |
T1510 | 2808-2809 | , | denotes | , |
T1511 | 2810-2815 | JJ | denotes | NF-κB |
T1512 | 2816-2829 | NN | denotes | transcription |
T1513 | 2830-2838 | NN | denotes | activity |
T1514 | 2839-2841 | VBZ | denotes | is |
T1515 | 2842-2852 | VBN | denotes | associated |
T1516 | 2853-2857 | IN | denotes | with |
T1517 | 2858-2873 | NN | denotes | phosphorylation |
T1518 | 2874-2876 | IN | denotes | on |
T1519 | 2877-2883 | NNP | denotes | Ser276 |
T1520 | 2884-2887 | CC | denotes | and |
T1521 | 2888-2894 | NNP | denotes | Ser536 |
T1522 | 2895-2899 | WDT | denotes | that |
T1523 | 2900-2902 | VBZ | denotes | is |
T1524 | 2903-2912 | VBN | denotes | regulated |
T1525 | 2913-2920 | IN | denotes | through |
T1526 | 2921-2928 | NN | denotes | protein |
T1527 | 2929-2935 | NN | denotes | kinase |
T1528 | 2936-2937 | DT | denotes | A |
T1529 | 2938-2939 | -LRB- | denotes | ( |
T1530 | 2939-2942 | NNP | denotes | PKA |
T1531 | 2942-2943 | -RRB- | denotes | ) |
T1532 | 2944-2947 | CC | denotes | and |
T1533 | 2948-2952 | NNP | denotes | IKKβ |
T1534 | 2953-2965 | RB | denotes | respectively |
T1535 | 2965-2966 | NNP | denotes | [ |
T1536 | 2966-2968 | CD | denotes | 16 |
T1537 | 2968-2969 | NNP | denotes | ] |
T1538 | 2969-2970 | , | denotes | , |
T1539 | 2971-2972 | NNP | denotes | [ |
T1540 | 2972-2974 | CD | denotes | 19 |
T1541 | 2974-2975 | NNP | denotes | ] |
T1542 | 2975-2976 | . | denotes | . |
T1543 | 2977-2979 | IN | denotes | In |
T1544 | 2980-2985 | JJ | denotes | human |
T1545 | 2986-2987 | NNP | denotes | T |
T1546 | 2988-2993 | NNS | denotes | cells |
T1547 | 2993-2994 | , | denotes | , |
T1548 | 2995-3000 | NNP | denotes | NF-κB |
T1549 | 3001-3004 | CD | denotes | p65 |
T1550 | 3005-3007 | VBZ | denotes | is |
T1551 | 3008-3022 | RB | denotes | constitutively |
T1552 | 3023-3037 | VBN | denotes | phosphorylated |
T1553 | 3038-3040 | IN | denotes | on |
T1554 | 3041-3047 | CD | denotes | Ser536 |
T1555 | 3048-3050 | TO | denotes | to |
T1556 | 3051-3061 | VB | denotes | facilitate |
T1557 | 3062-3067 | NNP | denotes | NF-κB |
T1558 | 3068-3071 | CD | denotes | p65 |
T1559 | 3072-3079 | JJ | denotes | nuclear |
T1560 | 3080-3093 | NN | denotes | translocation |
T1561 | 3094-3103 | VBG | denotes | following |
T1562 | 3104-3112 | JJ | denotes | cellular |
T1563 | 3113-3124 | NN | denotes | stimulation |
T1564 | 3125-3126 | NNP | denotes | [ |
T1565 | 3126-3128 | CD | denotes | 20 |
T1566 | 3128-3129 | NNP | denotes | ] |
T1567 | 3129-3130 | . | denotes | . |
T1568 | 3131-3143 | VBG | denotes | Accumulating |
T1569 | 3144-3152 | NN | denotes | evidence |
T1570 | 3153-3160 | VBZ | denotes | reveals |
T1571 | 3161-3165 | IN | denotes | that |
T1572 | 3166-3171 | NNP | denotes | NF-κB |
T1573 | 3172-3175 | CD | denotes | p65 |
T1574 | 3176-3191 | NN | denotes | phosphorylation |
T1575 | 3192-3194 | IN | denotes | at |
T1576 | 3195-3201 | NNP | denotes | Ser276 |
T1577 | 3202-3204 | VBZ | denotes | is |
T1578 | 3205-3212 | JJ | denotes | crucial |
T1579 | 3213-3216 | IN | denotes | for |
T1580 | 3217-3220 | PRP$ | denotes | its |
T1581 | 3221-3236 | JJ | denotes | transcriptional |
T1582 | 3237-3245 | NN | denotes | activity |
T1583 | 3245-3246 | . | denotes | . |
T1584 | 3247-3251 | IN | denotes | Upon |
T1585 | 3252-3259 | JJ | denotes | nuclear |
T1586 | 3260-3273 | NN | denotes | translocation |
T1587 | 3273-3274 | , | denotes | , |
T1588 | 3275-3290 | NN | denotes | phosphorylation |
T1589 | 3291-3293 | IN | denotes | of |
T1590 | 3294-3300 | NNP | denotes | Ser276 |
T1591 | 3301-3303 | IN | denotes | on |
T1592 | 3304-3309 | NNP | denotes | NF-κB |
T1593 | 3310-3313 | CD | denotes | p65 |
T1594 | 3314-3316 | IN | denotes | by |
T1595 | 3317-3320 | NNP | denotes | PKA |
T1596 | 3321-3329 | VBZ | denotes | recruits |
T1597 | 3330-3333 | DT | denotes | the |
T1598 | 3334-3347 | NN | denotes | transcription |
T1599 | 3348-3360 | NN | denotes | co-activator |
T1600 | 3360-3361 | , | denotes | , |
T1601 | 3362-3366 | CD | denotes | p300 |
T1602 | 3367-3369 | TO | denotes | to |
T1603 | 3370-3380 | VB | denotes | potentiate |
T1604 | 3381-3396 | JJ | denotes | NF-κB-regulated |
T1605 | 3397-3401 | NN | denotes | gene |
T1606 | 3402-3415 | NN | denotes | transcription |
T1607 | 3416-3417 | NNP | denotes | [ |
T1608 | 3417-3419 | CD | denotes | 21 |
T1609 | 3419-3420 | NNP | denotes | ] |
T1610 | 3420-3421 | . | denotes | . |
T1611 | 3422-3429 | RB | denotes | However |
T1612 | 3429-3430 | , | denotes | , |
T1613 | 3431-3436 | JJ | denotes | other |
T1614 | 3437-3444 | NNS | denotes | studies |
T1615 | 3445-3449 | VBP | denotes | show |
T1616 | 3450-3454 | IN | denotes | that |
T1617 | 3455-3458 | NNP | denotes | PKA |
T1618 | 3459-3467 | VBZ | denotes | inhibits |
T1619 | 3468-3483 | JJ | denotes | NF-κB-regulated |
T1620 | 3484-3488 | NN | denotes | gene |
T1621 | 3489-3499 | NN | denotes | expression |
T1622 | 3500-3502 | IN | denotes | by |
T1623 | 3503-3514 | VBG | denotes | stabilizing |
T1624 | 3515-3519 | NNP | denotes | IκBα |
T1625 | 3520-3521 | NNP | denotes | [ |
T1626 | 3521-3523 | CD | denotes | 22 |
T1627 | 3523-3524 | NNP | denotes | ] |
T1628 | 3524-3525 | , | denotes | , |
T1629 | 3526-3527 | NNP | denotes | [ |
T1630 | 3527-3529 | CD | denotes | 23 |
T1631 | 3529-3530 | NNP | denotes | ] |
T1632 | 3530-3531 | . | denotes | . |
T1633 | 3532-3545 | RB | denotes | Interestingly |
T1634 | 3545-3546 | , | denotes | , |
T1635 | 3547-3550 | DT | denotes | the |
T1636 | 3551-3567 | JJ | denotes | serine/threonine |
T1637 | 3568-3574 | NN | denotes | kinase |
T1638 | 3575-3580 | NN | denotes | Pim-1 |
T1639 | 3581-3589 | RB | denotes | directly |
T1640 | 3590-3604 | VBZ | denotes | phosphorylates |
T1641 | 3605-3610 | NNP | denotes | NF-κB |
T1642 | 3611-3614 | CD | denotes | p65 |
T1643 | 3615-3617 | IN | denotes | at |
T1644 | 3618-3624 | CD | denotes | Ser276 |
T1645 | 3625-3627 | IN | denotes | by |
T1646 | 3628-3639 | VBG | denotes | stabilizing |
T1647 | 3640-3642 | TO | denotes | to |
T1648 | 3643-3650 | VB | denotes | prevent |
T1649 | 3651-3671 | JJ | denotes | ubiquitin-proteasome |
T1650 | 3672-3683 | NN | denotes | degradation |
T1651 | 3684-3685 | NNP | denotes | [ |
T1652 | 3685-3687 | CD | denotes | 24 |
T1653 | 3687-3688 | NNP | denotes | ] |
T1654 | 3688-3689 | . | denotes | . |
T1655 | 3690-3697 | JJ | denotes | Several |
T1656 | 3698-3703 | JJ | denotes | other |
T1657 | 3704-3719 | NN | denotes | phosphorylation |
T1658 | 3720-3725 | NNS | denotes | sites |
T1659 | 3726-3729 | VBP | denotes | are |
T1660 | 3730-3734 | RB | denotes | also |
T1661 | 3735-3744 | VBN | denotes | described |
T1662 | 3745-3747 | TO | denotes | to |
T1663 | 3748-3755 | VB | denotes | enhance |
T1664 | 3756-3761 | JJ | denotes | NF-κB |
T1665 | 3762-3766 | NN | denotes | gene |
T1666 | 3767-3782 | NN | denotes | transactivation |
T1667 | 3783-3784 | NNP | denotes | [ |
T1668 | 3784-3786 | CD | denotes | 25 |
T1669 | 3786-3787 | NNP | denotes | ] |
T1670 | 3787-3788 | . | denotes | . |
T1671 | 3789-3793 | RB | denotes | Here |
T1672 | 3793-3794 | , | denotes | , |
T1673 | 3795-3797 | PRP | denotes | we |
T1674 | 3798-3809 | VBP | denotes | investigate |
T1675 | 3810-3813 | DT | denotes | the |
T1676 | 3814-3818 | NN | denotes | role |
T1677 | 3819-3821 | IN | denotes | of |
T1678 | 3822-3829 | NN | denotes | protein |
T1679 | 3830-3836 | NN | denotes | kinase |
T1680 | 3837-3838 | NNP | denotes | C |
T1681 | 3839-3840 | -LRB- | denotes | ( |
T1682 | 3840-3843 | NNP | denotes | PKC |
T1683 | 3843-3844 | -RRB- | denotes | ) |
T1684 | 3845-3847 | IN | denotes | in |
T1685 | 3848-3864 | NNP | denotes | M-CSF-stimulated |
T1686 | 3865-3870 | NNP | denotes | NF-κB |
T1687 | 3871-3881 | NN | denotes | activation |
T1688 | 3881-3882 | . | denotes | . |
T1689 | 3883-3886 | NNP | denotes | PKC |
T1690 | 3887-3895 | NNS | denotes | proteins |
T1691 | 3896-3899 | VBP | denotes | are |
T1692 | 3900-3915 | JJ | denotes | multifunctional |
T1693 | 3916-3923 | NNS | denotes | kinases |
T1694 | 3924-3928 | WDT | denotes | that |
T1695 | 3929-3935 | VBP | denotes | differ |
T1696 | 3936-3938 | IN | denotes | in |
T1697 | 3939-3948 | NN | denotes | structure |
T1698 | 3948-3949 | , | denotes | , |
T1699 | 3950-3958 | NN | denotes | function |
T1700 | 3959-3962 | CC | denotes | and |
T1701 | 3963-3972 | NN | denotes | co-factor |
T1702 | 3973-3984 | NN | denotes | requirement |
T1703 | 3985-3986 | NNP | denotes | [ |
T1704 | 3986-3988 | CD | denotes | 26 |
T1705 | 3988-3989 | NNP | denotes | ] |
T1706 | 3989-3990 | . | denotes | . |
T1707 | 3991-3995 | NNS | denotes | PKCs |
T1708 | 3996-3999 | VBP | denotes | are |
T1709 | 4000-4008 | VBN | denotes | involved |
T1710 | 4009-4011 | IN | denotes | in |
T1711 | 4012-4019 | JJ | denotes | diverse |
T1712 | 4020-4024 | NN | denotes | cell |
T1713 | 4025-4034 | NNS | denotes | responses |
T1714 | 4034-4035 | , | denotes | , |
T1715 | 4036-4045 | VBG | denotes | including |
T1716 | 4046-4050 | NN | denotes | cell |
T1717 | 4051-4057 | NN | denotes | growth |
T1718 | 4057-4058 | , | denotes | , |
T1719 | 4059-4067 | NN | denotes | survival |
T1720 | 4067-4068 | , | denotes | , |
T1721 | 4069-4084 | NN | denotes | differentiation |
T1722 | 4085-4088 | CC | denotes | and |
T1723 | 4089-4100 | NN | denotes | development |
T1724 | 4101-4102 | NNP | denotes | [ |
T1725 | 4102-4104 | CD | denotes | 27 |
T1726 | 4104-4105 | NNP | denotes | ] |
T1727 | 4105-4106 | . | denotes | . |
T1728 | 4107-4110 | DT | denotes | The |
T1729 | 4111-4113 | CD | denotes | 12 |
T1730 | 4114-4121 | RB | denotes | closely |
T1731 | 4122-4129 | JJ | denotes | related |
T1732 | 4130-4137 | NNS | denotes | enzymes |
T1733 | 4138-4140 | IN | denotes | of |
T1734 | 4141-4144 | DT | denotes | the |
T1735 | 4145-4148 | NNP | denotes | PKC |
T1736 | 4149-4155 | NN | denotes | family |
T1737 | 4156-4159 | VBP | denotes | are |
T1738 | 4160-4167 | VBN | denotes | divided |
T1739 | 4168-4172 | IN | denotes | into |
T1740 | 4173-4178 | CD | denotes | three |
T1741 | 4179-4186 | NNS | denotes | classes |
T1742 | 4186-4187 | : | denotes | : |
T1743 | 4188-4200 | JJ | denotes | conventional |
T1744 | 4201-4202 | -LRB- | denotes | ( |
T1745 | 4202-4207 | NNS | denotes | cPKCs |
T1746 | 4207-4208 | : | denotes | : |
T1747 | 4209-4210 | VB | denotes | α |
T1748 | 4211-4213 | NNP | denotes | βI |
T1749 | 4214-4217 | NNP | denotes | βII |
T1750 | 4218-4221 | CC | denotes | and |
T1751 | 4222-4223 | NNP | denotes | γ |
T1752 | 4224-4231 | VBP | denotes | require |
T1753 | 4232-4235 | JJ | denotes | Ca2 |
T1754 | 4235-4236 | NN | denotes | + |
T1755 | 4237-4240 | CC | denotes | and |
T1756 | 4241-4255 | NN | denotes | diacylglycerol |
T1757 | 4256-4257 | -LRB- | denotes | ( |
T1758 | 4257-4260 | NNP | denotes | DAG |
T1759 | 4260-4261 | -RRB- | denotes | ) |
T1760 | 4261-4262 | : | denotes | ; |
T1761 | 4263-4268 | NN | denotes | novel |
T1762 | 4269-4270 | -LRB- | denotes | ( |
T1763 | 4270-4275 | NNS | denotes | nPKCs |
T1764 | 4275-4276 | : | denotes | : |
T1765 | 4277-4278 | VB | denotes | δ |
T1766 | 4278-4279 | , | denotes | , |
T1767 | 4280-4281 | VB | denotes | ε |
T1768 | 4281-4282 | , | denotes | , |
T1769 | 4283-4284 | VB | denotes | η |
T1770 | 4284-4285 | , | denotes | , |
T1771 | 4286-4287 | VB | denotes | θ |
T1772 | 4288-4291 | CC | denotes | and |
T1773 | 4292-4293 | VB | denotes | μ |
T1774 | 4293-4294 | -RRB- | denotes | ) |
T1775 | 4295-4302 | VBP | denotes | require |
T1776 | 4303-4306 | NNP | denotes | DAG |
T1777 | 4306-4307 | : | denotes | ; |
T1778 | 4308-4311 | CC | denotes | and |
T1779 | 4312-4320 | JJ | denotes | atypical |
T1780 | 4321-4322 | -LRB- | denotes | ( |
T1781 | 4322-4327 | NNS | denotes | aPKCs |
T1782 | 4327-4328 | : | denotes | : |
T1783 | 4329-4330 | VB | denotes | ξ |
T1784 | 4330-4331 | , | denotes | , |
T1785 | 4332-4333 | VB | denotes | ι |
T1786 | 4334-4337 | CC | denotes | and |
T1787 | 4338-4339 | VB | denotes | λ |
T1788 | 4339-4340 | -RRB- | denotes | ) |
T1789 | 4341-4348 | VBP | denotes | require |
T1790 | 4349-4356 | CC | denotes | neither |
T1791 | 4357-4360 | VBP | denotes | Ca2 |
T1792 | 4360-4361 | CD | denotes | + |
T1793 | 4362-4365 | CC | denotes | nor |
T1794 | 4366-4369 | NNP | denotes | DAG |
T1795 | 4369-4370 | . | denotes | . |
T1796 | 4371-4380 | NNS | denotes | Monocytes |
T1797 | 4381-4384 | CC | denotes | and |
T1798 | 4385-4396 | NNS | denotes | macrophages |
T1799 | 4397-4410 | RB | denotes | predominantly |
T1800 | 4411-4418 | VBP | denotes | express |
T1801 | 4419-4431 | JJ | denotes | conventional |
T1802 | 4432-4435 | NNP | denotes | PKC |
T1803 | 4436-4444 | NNS | denotes | isoforms |
T1804 | 4445-4446 | -LRB- | denotes | ( |
T1805 | 4446-4450 | NNP | denotes | PKCα |
T1806 | 4451-4456 | NNP | denotes | PKCβI |
T1807 | 4457-4460 | CC | denotes | and |
T1808 | 4461-4467 | NNP | denotes | PKCβII |
T1809 | 4467-4468 | -RRB- | denotes | ) |
T1810 | 4469-4472 | CC | denotes | and |
T1811 | 4473-4478 | JJ | denotes | novel |
T1812 | 4479-4483 | NNS | denotes | PKCs |
T1813 | 4484-4485 | -LRB- | denotes | ( |
T1814 | 4485-4489 | NNP | denotes | PKCδ |
T1815 | 4490-4493 | CC | denotes | and |
T1816 | 4494-4498 | NNP | denotes | PKCε |
T1817 | 4498-4499 | -RRB- | denotes | ) |
T1818 | 4499-4500 | . | denotes | . |
T1819 | 4501-4513 | JJ | denotes | Conventional |
T1820 | 4514-4518 | NNS | denotes | PKCs |
T1821 | 4519-4527 | VB | denotes | regulate |
T1822 | 4528-4543 | NN | denotes | differentiation |
T1823 | 4544-4546 | IN | denotes | of |
T1824 | 4547-4550 | DT | denotes | the |
T1825 | 4551-4556 | JJ | denotes | human |
T1826 | 4557-4570 | JJ | denotes | promyelocytic |
T1827 | 4571-4579 | NN | denotes | leukemia |
T1828 | 4580-4584 | NN | denotes | cell |
T1829 | 4585-4589 | NN | denotes | line |
T1830 | 4590-4594 | CD | denotes | HL60 |
T1831 | 4595-4597 | TO | denotes | to |
T1832 | 4598-4609 | NNS | denotes | macrophages |
T1833 | 4610-4611 | NNP | denotes | [ |
T1834 | 4611-4613 | CD | denotes | 28 |
T1835 | 4613-4614 | NNP | denotes | ] |
T1836 | 4614-4615 | . | denotes | . |
T1837 | 4616-4620 | NNP | denotes | PKCα |
T1838 | 4621-4628 | VBZ | denotes | induces |
T1839 | 4629-4634 | NNP | denotes | IL-1α |
T1840 | 4634-4635 | , | denotes | , |
T1841 | 4636-4640 | NNP | denotes | iNOS |
T1842 | 4641-4644 | CC | denotes | and |
T1843 | 4645-4649 | NNP | denotes | TNFα |
T1844 | 4650-4654 | NNP | denotes | mRNA |
T1845 | 4655-4665 | NN | denotes | production |
T1846 | 4666-4671 | IN | denotes | after |
T1847 | 4672-4690 | NN | denotes | lipopolysaccharide |
T1848 | 4691-4692 | -LRB- | denotes | ( |
T1849 | 4692-4695 | NNP | denotes | LPS |
T1850 | 4695-4696 | -RRB- | denotes | ) |
T1851 | 4697-4705 | NN | denotes | exposure |
T1852 | 4706-4707 | NNP | denotes | [ |
T1853 | 4707-4709 | CD | denotes | 29 |
T1854 | 4709-4710 | NNP | denotes | ] |
T1855 | 4710-4711 | . | denotes | . |
T1856 | 4712-4714 | IN | denotes | In |
T1857 | 4715-4723 | NN | denotes | addition |
T1858 | 4723-4724 | , | denotes | , |
T1859 | 4725-4737 | VBG | denotes | accumulating |
T1860 | 4738-4746 | NN | denotes | evidence |
T1861 | 4747-4755 | VBZ | denotes | suggests |
T1862 | 4756-4760 | IN | denotes | that |
T1863 | 4761-4773 | JJ | denotes | conventional |
T1864 | 4774-4778 | NNS | denotes | PKCs |
T1865 | 4779-4783 | IN | denotes | like |
T1866 | 4784-4788 | NNP | denotes | PKCα |
T1867 | 4789-4793 | VBP | denotes | have |
T1868 | 4794-4808 | JJ | denotes | anti-apoptotic |
T1869 | 4809-4818 | NNS | denotes | functions |
T1870 | 4818-4819 | . | denotes | . |
T1871 | 4820-4823 | IN | denotes | For |
T1872 | 4824-4831 | NN | denotes | example |
T1873 | 4831-4832 | , | denotes | , |
T1874 | 4833-4837 | NNP | denotes | PKCα |
T1875 | 4838-4840 | VBZ | denotes | is |
T1876 | 4841-4854 | VBN | denotes | overexpressed |
T1877 | 4855-4857 | IN | denotes | in |
T1878 | 4858-4859 | DT | denotes | a |
T1879 | 4860-4867 | NN | denotes | variety |
T1880 | 4868-4870 | IN | denotes | of |
T1881 | 4871-4876 | NN | denotes | tumor |
T1882 | 4877-4882 | NNS | denotes | cells |
T1883 | 4883-4892 | VBG | denotes | including |
T1884 | 4893-4900 | NNS | denotes | gliomas |
T1885 | 4900-4901 | , | denotes | , |
T1886 | 4902-4907 | NN | denotes | liver |
T1887 | 4907-4908 | , | denotes | , |
T1888 | 4909-4912 | CC | denotes | and |
T1889 | 4913-4917 | NN | denotes | lung |
T1890 | 4918-4919 | NNP | denotes | [ |
T1891 | 4919-4921 | CD | denotes | 30 |
T1892 | 4921-4922 | NNP | denotes | ] |
T1893 | 4922-4923 | , | denotes | , |
T1894 | 4924-4925 | NNP | denotes | [ |
T1895 | 4925-4927 | CD | denotes | 31 |
T1896 | 4927-4928 | NNP | denotes | ] |
T1897 | 4928-4929 | . | denotes | . |
T1898 | 4930-4932 | IN | denotes | In |
T1899 | 4933-4943 | JJ | denotes | epithelial |
T1900 | 4944-4949 | NNS | denotes | cells |
T1901 | 4949-4950 | , | denotes | , |
T1902 | 4951-4961 | NN | denotes | inhibition |
T1903 | 4962-4964 | IN | denotes | of |
T1904 | 4965-4969 | NNP | denotes | PKCα |
T1905 | 4970-4977 | VBZ | denotes | induces |
T1906 | 4978-4992 | JJ | denotes | PKCδ-dependent |
T1907 | 4993-5002 | NN | denotes | apoptosis |
T1908 | 5003-5004 | NNP | denotes | [ |
T1909 | 5004-5006 | CD | denotes | 31 |
T1910 | 5006-5007 | NNP | denotes | ] |
T1911 | 5007-5008 | . | denotes | . |
T1912 | 5009-5022 | RB | denotes | Interestingly |
T1913 | 5022-5023 | , | denotes | , |
T1914 | 5024-5026 | IN | denotes | in |
T1915 | 5027-5032 | JJ | denotes | human |
T1916 | 5033-5042 | NNS | denotes | monocytes |
T1917 | 5043-5046 | CC | denotes | and |
T1918 | 5047-5059 | JJ | denotes | premonocytic |
T1919 | 5060-5065 | NN | denotes | THP-1 |
T1920 | 5066-5074 | NN | denotes | leukemia |
T1921 | 5075-5080 | NNS | denotes | cells |
T1922 | 5080-5081 | , | denotes | , |
T1923 | 5082-5087 | NN | denotes | novel |
T1924 | 5088-5092 | NNS | denotes | PKCs |
T1925 | 5093-5097 | IN | denotes | like |
T1926 | 5098-5102 | NNP | denotes | PKCδ |
T1927 | 5103-5107 | VBP | denotes | have |
T1928 | 5108-5111 | DT | denotes | the |
T1929 | 5112-5120 | JJ | denotes | opposite |
T1930 | 5121-5127 | NN | denotes | effect |
T1931 | 5128-5130 | IN | denotes | on |
T1932 | 5131-5135 | NN | denotes | cell |
T1933 | 5136-5144 | NN | denotes | survival |
T1934 | 5144-5145 | , | denotes | , |
T1935 | 5146-5150 | NNP | denotes | Voss |
T1936 | 5151-5153 | FW | denotes | et |
T1937 | 5154-5156 | FW | denotes | al |
T1938 | 5157-5163 | VBD | denotes | showed |
T1939 | 5164-5168 | IN | denotes | that |
T1940 | 5169-5173 | NNP | denotes | PKCδ |
T1941 | 5174-5182 | RB | denotes | directly |
T1942 | 5183-5197 | VBZ | denotes | phosphorylates |
T1943 | 5198-5207 | JJ | denotes | caspase-3 |
T1944 | 5208-5211 | CC | denotes | and |
T1945 | 5212-5220 | VBZ | denotes | promotes |
T1946 | 5221-5238 | JJ | denotes | etoposide-induced |
T1947 | 5239-5248 | NN | denotes | apoptosis |
T1948 | 5249-5250 | NNP | denotes | [ |
T1949 | 5250-5252 | CD | denotes | 32 |
T1950 | 5252-5253 | NNP | denotes | ] |
T1951 | 5253-5254 | . | denotes | . |
T1952 | 5255-5263 | RB | denotes | Moreover |
T1953 | 5263-5264 | , | denotes | , |
T1954 | 5265-5273 | NN | denotes | knockout |
T1955 | 5274-5279 | NN | denotes | mouse |
T1956 | 5280-5287 | NNS | denotes | studies |
T1957 | 5288-5295 | VBP | denotes | suggest |
T1958 | 5296-5300 | IN | denotes | that |
T1959 | 5301-5308 | DT | denotes | another |
T1960 | 5309-5314 | NN | denotes | novel |
T1961 | 5315-5318 | NNP | denotes | PKC |
T1962 | 5318-5319 | , | denotes | , |
T1963 | 5320-5324 | NNP | denotes | PKCε |
T1964 | 5325-5327 | VBZ | denotes | is |
T1965 | 5328-5338 | RB | denotes | critically |
T1966 | 5339-5347 | VBN | denotes | involved |
T1967 | 5348-5350 | IN | denotes | in |
T1968 | 5351-5356 | JJ | denotes | early |
T1969 | 5357-5369 | JJ | denotes | LPS-mediated |
T1970 | 5370-5379 | VBG | denotes | signaling |
T1971 | 5380-5382 | IN | denotes | in |
T1972 | 5383-5392 | VBN | denotes | activated |
T1973 | 5393-5404 | NNS | denotes | macrophages |
T1974 | 5405-5406 | NNP | denotes | [ |
T1975 | 5406-5408 | CD | denotes | 33 |
T1976 | 5408-5409 | NNP | denotes | ] |
T1977 | 5409-5410 | . | denotes | . |
T1978 | 5411-5421 | RB | denotes | Previously |
T1979 | 5421-5422 | , | denotes | , |
T1980 | 5423-5425 | PRP | denotes | we |
T1981 | 5426-5434 | VBD | denotes | reported |
T1982 | 5435-5439 | IN | denotes | that |
T1983 | 5440-5445 | NNP | denotes | M-CSF |
T1984 | 5446-5454 | VBZ | denotes | promotes |
T1985 | 5455-5463 | NN | denotes | monocyte |
T1986 | 5464-5472 | NN | denotes | survival |
T1987 | 5473-5480 | IN | denotes | through |
T1988 | 5481-5484 | DT | denotes | the |
T1989 | 5485-5495 | NN | denotes | activation |
T1990 | 5496-5498 | IN | denotes | of |
T1991 | 5499-5502 | DT | denotes | the |
T1992 | 5503-5512 | NN | denotes | PI3-K/AKT |
T1993 | 5513-5520 | NN | denotes | pathway |
T1994 | 5521-5522 | NNP | denotes | [ |
T1995 | 5522-5523 | CD | denotes | 3 |
T1996 | 5523-5524 | NNP | denotes | ] |
T1997 | 5524-5525 | . | denotes | . |
T1998 | 5526-5528 | IN | denotes | In |
T1999 | 5529-5537 | NN | denotes | addition |
T2000 | 5538-5540 | TO | denotes | to |
T2001 | 5541-5544 | NNP | denotes | AKT |
T2002 | 5545-5555 | NN | denotes | activation |
T2003 | 5555-5556 | , | denotes | , |
T2004 | 5557-5562 | NNP | denotes | M-CSF |
T2005 | 5563-5573 | VBZ | denotes | stimulates |
T2006 | 5574-5577 | NNP | denotes | PKC |
T2007 | 5578-5580 | IN | denotes | in |
T2008 | 5581-5586 | JJ | denotes | human |
T2009 | 5587-5596 | NNS | denotes | monocytes |
T2010 | 5597-5600 | CC | denotes | and |
T2011 | 5601-5610 | NNS | denotes | increases |
T2012 | 5611-5616 | NNP | denotes | NF-κB |
T2013 | 5617-5620 | NNP | denotes | DNA |
T2014 | 5621-5628 | JJ | denotes | binding |
T2015 | 5629-5630 | NNP | denotes | [ |
T2016 | 5630-5632 | CD | denotes | 34 |
T2017 | 5632-5633 | NNP | denotes | ] |
T2018 | 5633-5634 | . | denotes | . |
T2019 | 5635-5642 | RB | denotes | However |
T2020 | 5642-5643 | , | denotes | , |
T2021 | 5644-5651 | IN | denotes | whether |
T2022 | 5652-5655 | NNP | denotes | PKC |
T2023 | 5656-5662 | CC | denotes | and/or |
T2024 | 5663-5668 | NNP | denotes | NF-κB |
T2025 | 5669-5679 | NN | denotes | activation |
T2026 | 5680-5682 | VBZ | denotes | is |
T2027 | 5683-5691 | JJ | denotes | critical |
T2028 | 5692-5694 | IN | denotes | in |
T2029 | 5695-5711 | JJ | denotes | M-CSF-stimulated |
T2030 | 5712-5723 | NN | denotes | mononuclear |
T2031 | 5724-5733 | NN | denotes | phagocyte |
T2032 | 5734-5742 | NN | denotes | survival |
T2033 | 5743-5749 | CC | denotes | and/or |
T2034 | 5750-5765 | NN | denotes | differentiation |
T2035 | 5766-5768 | VBZ | denotes | is |
T2036 | 5769-5776 | JJ | denotes | unclear |
T2037 | 5776-5777 | . | denotes | . |
T2038 | 5778-5780 | IN | denotes | In |
T2039 | 5781-5786 | JJ | denotes | other |
T2040 | 5787-5792 | NNS | denotes | cells |
T2041 | 5792-5793 | , | denotes | , |
T2042 | 5794-5797 | NNP | denotes | PKC |
T2043 | 5798-5803 | VBZ | denotes | plays |
T2044 | 5804-5806 | DT | denotes | an |
T2045 | 5807-5816 | JJ | denotes | important |
T2046 | 5817-5821 | NN | denotes | role |
T2047 | 5822-5824 | IN | denotes | in |
T2048 | 5825-5830 | JJ | denotes | NF-κB |
T2049 | 5831-5841 | NN | denotes | activation |
T2050 | 5842-5845 | CC | denotes | and |
T2051 | 5846-5850 | NN | denotes | cell |
T2052 | 5851-5859 | NN | denotes | survival |
T2053 | 5860-5861 | NNP | denotes | [ |
T2054 | 5861-5863 | CD | denotes | 35 |
T2055 | 5863-5864 | NNP | denotes | ] |
T2056 | 5864-5865 | , | denotes | , |
T2057 | 5866-5873 | RB | denotes | however |
T2058 | 5874-5877 | DT | denotes | the |
T2059 | 5878-5886 | JJ | denotes | specific |
T2060 | 5887-5897 | NNS | denotes | mechanisms |
T2061 | 5898-5900 | IN | denotes | of |
T2062 | 5901-5905 | DT | denotes | this |
T2063 | 5906-5916 | NN | denotes | activation |
T2064 | 5917-5920 | CC | denotes | and |
T2065 | 5921-5924 | DT | denotes | the |
T2066 | 5925-5935 | JJ | denotes | biological |
T2067 | 5936-5943 | NNS | denotes | effects |
T2068 | 5944-5946 | IN | denotes | on |
T2069 | 5947-5955 | JJ | denotes | cellular |
T2070 | 5956-5965 | NN | denotes | phenotype |
T2071 | 5966-5969 | VBP | denotes | are |
T2072 | 5970-5973 | RB | denotes | not |
T2073 | 5974-5979 | VBN | denotes | known |
T2074 | 5979-5980 | . | denotes | . |
T2075 | 5981-5990 | RB | denotes | Therefore |
T2076 | 5990-5991 | , | denotes | , |
T2077 | 5992-5994 | PRP | denotes | we |
T2078 | 5995-6002 | VBD | denotes | focused |
T2079 | 6003-6005 | IN | denotes | at |
T2080 | 6006-6019 | VBG | denotes | understanding |
T2081 | 6020-6023 | DT | denotes | the |
T2082 | 6024-6028 | NN | denotes | role |
T2083 | 6029-6031 | IN | denotes | of |
T2084 | 6032-6035 | NNP | denotes | PKC |
T2085 | 6036-6038 | IN | denotes | in |
T2086 | 6039-6042 | DT | denotes | the |
T2087 | 6043-6053 | NN | denotes | regulation |
T2088 | 6054-6056 | IN | denotes | of |
T2089 | 6057-6062 | JJ | denotes | NF-κB |
T2090 | 6063-6073 | NN | denotes | activation |
T2091 | 6074-6077 | CC | denotes | and |
T2092 | 6078-6091 | JJ | denotes | M-CSF-induced |
T2093 | 6092-6100 | NN | denotes | monocyte |
T2094 | 6101-6109 | NN | denotes | survival |
T2095 | 6109-6110 | . | denotes | . |
T2096 | 6111-6115 | RB | denotes | Here |
T2097 | 6116-6118 | PRP | denotes | we |
T2098 | 6119-6131 | VBZ | denotes | demonstrates |
T2099 | 6132-6136 | IN | denotes | that |
T2100 | 6137-6142 | NNP | denotes | M-CSF |
T2101 | 6143-6154 | VBD | denotes | upregulated |
T2102 | 6155-6158 | DT | denotes | the |
T2103 | 6159-6164 | JJ | denotes | NF-κB |
T2104 | 6165-6178 | NN | denotes | transcription |
T2105 | 6179-6182 | CC | denotes | and |
T2106 | 6183-6187 | NN | denotes | cell |
T2107 | 6188-6196 | NN | denotes | survival |
T2108 | 6197-6199 | IN | denotes | in |
T2109 | 6200-6205 | JJ | denotes | human |
T2110 | 6206-6209 | CC | denotes | and |
T2111 | 6210-6215 | NN | denotes | mouse |
T2112 | 6216-6227 | NNS | denotes | macrophages |
T2113 | 6227-6228 | . | denotes | . |
T2114 | 6229-6233 | DT | denotes | This |
T2115 | 6234-6242 | NN | denotes | activity |
T2116 | 6243-6246 | VBD | denotes | was |
T2117 | 6247-6254 | VBN | denotes | reduced |
T2118 | 6255-6257 | IN | denotes | by |
T2119 | 6258-6261 | DT | denotes | the |
T2120 | 6262-6274 | JJ | denotes | conventional |
T2121 | 6274-6275 | , | denotes | , |
T2122 | 6276-6279 | CC | denotes | but |
T2123 | 6280-6283 | RB | denotes | not |
T2124 | 6284-6289 | JJ | denotes | novel |
T2125 | 6289-6290 | , | denotes | , |
T2126 | 6291-6294 | NNP | denotes | PKC |
T2127 | 6295-6305 | NNS | denotes | inhibitors |
T2128 | 6305-6306 | , | denotes | , |
T2129 | 6307-6315 | JJ | denotes | dominant |
T2130 | 6316-6324 | JJ | denotes | negative |
T2131 | 6325-6329 | NNP | denotes | PKCα |
T2132 | 6330-6340 | NNS | denotes | constructs |
T2133 | 6341-6343 | CC | denotes | or |
T2134 | 6344-6348 | NNP | denotes | PKCα |
T2135 | 6349-6354 | NNP | denotes | siRNA |
T2136 | 6354-6355 | . | denotes | . |
T2137 | 6356-6368 | JJ | denotes | Conventional |
T2138 | 6369-6372 | NNP | denotes | PKC |
T2139 | 6373-6382 | VBN | denotes | regulated |
T2140 | 6383-6398 | JJ | denotes | NF-κB-regulated |
T2141 | 6399-6403 | NN | denotes | gene |
T2142 | 6404-6414 | NN | denotes | expression |
T2143 | 6415-6418 | CC | denotes | and |
T2144 | 6419-6434 | NN | denotes | phosphorylation |
T2145 | 6435-6437 | IN | denotes | of |
T2146 | 6438-6444 | NNP | denotes | Ser276 |
T2147 | 6445-6447 | IN | denotes | of |
T2148 | 6448-6453 | NNP | denotes | NF-κB |
T2149 | 6454-6457 | CD | denotes | p65 |
T2150 | 6458-6466 | VBD | denotes | occurred |
T2151 | 6467-6469 | IN | denotes | in |
T2152 | 6470-6472 | DT | denotes | an |
T2153 | 6473-6488 | JJ | denotes | M-CSF-dependent |
T2154 | 6489-6496 | NN | denotes | fashion |
T2155 | 6497-6508 | VBG | denotes | correlating |
T2156 | 6509-6513 | IN | denotes | with |
T2157 | 6514-6517 | PRP$ | denotes | its |
T2158 | 6518-6525 | JJ | denotes | maximal |
T2159 | 6526-6541 | JJ | denotes | transcriptional |
T2160 | 6542-6550 | NN | denotes | activity |
T2161 | 6550-6551 | . | denotes | . |
T2162 | 6552-6563 | RB | denotes | Furthermore |
T2163 | 6563-6564 | , | denotes | , |
T2164 | 6565-6579 | JJ | denotes | PKCα-regulated |
T2165 | 6580-6595 | NN | denotes | phosphorylation |
T2166 | 6596-6598 | IN | denotes | of |
T2167 | 6599-6605 | NNP | denotes | Ser276 |
T2168 | 6606-6608 | IN | denotes | of |
T2169 | 6609-6614 | NNP | denotes | NF-κB |
T2170 | 6615-6618 | CD | denotes | p65 |
T2171 | 6619-6624 | VBZ | denotes | plays |
T2172 | 6625-6627 | DT | denotes | an |
T2173 | 6628-6637 | JJ | denotes | important |
T2174 | 6638-6642 | NN | denotes | role |
T2175 | 6643-6645 | IN | denotes | in |
T2176 | 6646-6656 | VBG | denotes | regulating |
T2177 | 6657-6660 | PRP$ | denotes | its |
T2178 | 6661-6669 | NN | denotes | activity |
T2179 | 6670-6672 | IN | denotes | in |
T2180 | 6673-6684 | NN | denotes | mononuclear |
T2181 | 6685-6695 | NNS | denotes | phagocytes |
T2182 | 6696-6699 | CC | denotes | and |
T2183 | 6700-6706 | JJ | denotes | murine |
T2184 | 6707-6716 | JJ | denotes | embryonic |
T2185 | 6717-6728 | NNS | denotes | fibroblasts |
T2186 | 6728-6729 | . | denotes | . |
T14523 | 530-539 | JJ | denotes | important |
T14524 | 540-542 | IN | denotes | in |
R646 | T1018 | T1020 | nsubjpass | Monocytes,produced |
R647 | T1019 | T1020 | auxpass | are,produced |
R648 | T1020 | T1020 | ROOT | produced,produced |
R649 | T1021 | T1020 | prep | in,produced |
R650 | T1022 | T1024 | det | the,marrow |
R651 | T1023 | T1024 | compound | bone,marrow |
R652 | T1024 | T1021 | pobj | marrow,in |
R653 | T1025 | T1020 | cc | and,produced |
R654 | T1026 | T1020 | conj | circulate,produced |
R655 | T1027 | T1026 | prep | in,circulate |
R656 | T1028 | T1027 | pobj | blood,in |
R657 | T1029 | T1026 | prep | for,circulate |
R658 | T1030 | T1029 | pobj | 24,for |
R659 | T1031 | T1032 | nummod | 48,hours |
R660 | T1032 | T1030 | appos | hours,24 |
R661 | T1033 | T1035 | nmod | [,] |
R662 | T1034 | T1035 | nummod | 1,] |
R663 | T1035 | T1032 | appos | ],hours |
R664 | T1036 | T1020 | punct | .,produced |
R665 | T1037 | T1044 | prep | In,die |
R666 | T1038 | T1039 | det | the,absence |
R667 | T1039 | T1037 | pobj | absence,In |
R668 | T1040 | T1039 | prep | of,absence |
R669 | T1041 | T1040 | pobj | serum,of |
R670 | T1042 | T1044 | punct | ",",die |
R671 | T1043 | T1044 | nsubj | monocytes,die |
R672 | T1044 | T1044 | ROOT | die,die |
R673 | T1045 | T1044 | prep | via,die |
R674 | T1046 | T1047 | compound | apoptosis,[ |
R675 | T1047 | T1045 | pobj | [,via |
R676 | T1048 | T1049 | nummod | 1,] |
R677 | T1049 | T1044 | advcl | ],die |
R678 | T1050 | T1049 | punct | ",",] |
R679 | T1051 | T1053 | nmod | [,] |
R680 | T1052 | T1053 | nummod | 2,] |
R681 | T1053 | T1049 | appos | ],] |
R682 | T1054 | T1044 | punct | .,die |
R683 | T1055 | T1057 | nmod | Macrophage,factor |
R684 | T1056 | T1057 | amod | colony-stimulating,factor |
R685 | T1057 | T1061 | nsubj | factor,stimulates |
R686 | T1058 | T1059 | punct | (,M-CSF |
R687 | T1059 | T1057 | appos | M-CSF,factor |
R688 | T1060 | T1057 | punct | ),factor |
R689 | T1061 | T1061 | ROOT | stimulates,stimulates |
R690 | T1062 | T1064 | amod | mononuclear,survival |
R691 | T1063 | T1064 | amod | phagocyte,survival |
R692 | T1064 | T1069 | nmod | survival,] |
R693 | T1065 | T1064 | cc | and,survival |
R694 | T1066 | T1067 | compound | differentiation,[ |
R695 | T1067 | T1064 | conj | [,survival |
R696 | T1068 | T1069 | nummod | 3,] |
R697 | T1069 | T1061 | dobj | ],stimulates |
R698 | T1070 | T1061 | punct | .,stimulates |
R699 | T1071 | T1079 | advmod | Importantly,associated |
R700 | T1072 | T1079 | punct | ",",associated |
R701 | T1073 | T1075 | amod | M-CSF-mediated,survival |
R702 | T1074 | T1075 | compound | cell,survival |
R703 | T1075 | T1079 | nsubjpass | survival,associated |
R704 | T1076 | T1075 | cc | and,survival |
R705 | T1077 | T1075 | conj | activation,survival |
R706 | T1078 | T1079 | auxpass | is,associated |
R707 | T1079 | T1079 | ROOT | associated,associated |
R708 | T1080 | T1079 | prep | with,associated |
R709 | T1081 | T1082 | det | a,variety |
R710 | T1082 | T1080 | pobj | variety,with |
R711 | T1083 | T1082 | prep | of,variety |
R712 | T1084 | T1085 | amod | human,diseases |
R713 | T1085 | T1083 | pobj | diseases,of |
R714 | T1086 | T1085 | punct | ",",diseases |
R715 | T1087 | T1085 | prep | including,diseases |
R716 | T1088 | T1087 | pobj | atherosclerosis,including |
R717 | T1089 | T1088 | punct | ",",atherosclerosis |
R718 | T1090 | T1092 | nmod | transplant,sclerosis |
R719 | T1091 | T1092 | amod | vascular,sclerosis |
R720 | T1092 | T1088 | conj | sclerosis,atherosclerosis |
R721 | T1093 | T1092 | cc | and,sclerosis |
R722 | T1094 | T1095 | compound | breast,cancer |
R723 | T1095 | T1096 | compound | cancer,metastasis |
R724 | T1096 | T1092 | conj | metastasis,sclerosis |
R725 | T1097 | T1099 | nmod | [,] |
R726 | T1098 | T1099 | nummod | 4,] |
R727 | T1099 | T1088 | conj | ],atherosclerosis |
R728 | T1100 | T1099 | punct | ",",] |
R729 | T1101 | T1103 | nmod | [,] |
R730 | T1102 | T1103 | nummod | 5,] |
R731 | T1103 | T1099 | conj | ],] |
R732 | T1104 | T1103 | punct | ",",] |
R733 | T1105 | T1107 | nmod | [,] |
R734 | T1106 | T1107 | nummod | 6,] |
R735 | T1107 | T1103 | conj | ],] |
R736 | T1108 | T1079 | punct | .,associated |
R737 | T1109 | T1111 | nsubj | We,identified |
R738 | T1110 | T1111 | advmod | previously,identified |
R739 | T1111 | T1111 | ROOT | identified,identified |
R740 | T1112 | T1115 | mark | that,is |
R741 | T1113 | T1114 | amod | NF-κB,activation |
R742 | T1114 | T1115 | nsubj | activation,is |
R743 | T1115 | T1111 | ccomp | is,identified |
R744 | T1116 | T1115 | acomp | important,is |
R745 | T1117 | T1116 | prep | in,important |
R746 | T1118 | T1120 | amod | M-CSF-induced,survival |
R747 | T1119 | T1120 | compound | monocyte,survival |
R748 | T1120 | T1117 | pobj | survival,in |
R749 | T1121 | T1123 | nmod | [,] |
R750 | T1122 | T1123 | nummod | 7,] |
R751 | T1123 | T1115 | npadvmod | ],is |
R752 | T1124 | T1111 | punct | .,identified |
R753 | T1125 | T1139 | prep | In,regulates |
R754 | T1126 | T1125 | pobj | addition,In |
R755 | T1127 | T1126 | prep | to,addition |
R756 | T1128 | T1129 | poss | its,role |
R757 | T1129 | T1127 | pobj | role,to |
R758 | T1130 | T1129 | prep | in,role |
R759 | T1131 | T1133 | nmod | mononuclear,survival |
R760 | T1132 | T1133 | amod | phagocyte,survival |
R761 | T1133 | T1130 | pobj | survival,in |
R762 | T1134 | T1129 | punct | ",",role |
R763 | T1135 | T1137 | det | the,factor |
R764 | T1136 | T1137 | compound | transcription,factor |
R765 | T1137 | T1139 | nsubj | factor,regulates |
R766 | T1138 | T1139 | nsubj | NF-κB,regulates |
R767 | T1139 | T1139 | ROOT | regulates,regulates |
R768 | T1140 | T1141 | amod | numerous,genes |
R769 | T1141 | T1139 | dobj | genes,regulates |
R770 | T1142 | T1143 | nsubj | that,play |
R771 | T1143 | T1141 | relcl | play,genes |
R772 | T1144 | T1145 | amod | important,roles |
R773 | T1145 | T1143 | dobj | roles,play |
R774 | T1146 | T1143 | prep | in,play |
R775 | T1147 | T1148 | amod | cellular,signaling |
R776 | T1148 | T1146 | pobj | signaling,in |
R777 | T1149 | T1148 | punct | ",",signaling |
R778 | T1150 | T1151 | compound | stress,response |
R779 | T1151 | T1148 | conj | response,signaling |
R780 | T1152 | T1151 | punct | ",",response |
R781 | T1153 | T1154 | compound | cell,growth |
R782 | T1154 | T1151 | conj | growth,response |
R783 | T1155 | T1154 | punct | ",",growth |
R784 | T1156 | T1154 | conj | survival,growth |
R785 | T1157 | T1156 | punct | ",",survival |
R786 | T1158 | T1156 | conj | differentiation,survival |
R787 | T1159 | T1158 | cc | and,differentiation |
R788 | T1160 | T1158 | conj | inflammation,differentiation |
R789 | T1161 | T1158 | conj | [,differentiation |
R790 | T1162 | T1163 | nummod | 8,] |
R791 | T1163 | T1139 | npadvmod | ],regulates |
R792 | T1164 | T1139 | punct | .,regulates |
R793 | T1165 | T1166 | expl | There,are |
R794 | T1166 | T1166 | ROOT | are,are |
R795 | T1167 | T1168 | nummod | five,members |
R796 | T1168 | T1166 | attr | members,are |
R797 | T1169 | T1168 | prep | in,members |
R798 | T1170 | T1172 | det | the,family |
R799 | T1171 | T1172 | compound | NF-κB,family |
R800 | T1172 | T1169 | pobj | family,in |
R801 | T1173 | T1168 | punct | :,members |
R802 | T1174 | T1168 | appos | RelA/p65,members |
R803 | T1175 | T1174 | punct | ",",RelA/p65 |
R804 | T1176 | T1174 | appos | p50,RelA/p65 |
R805 | T1177 | T1176 | punct | ",",p50 |
R806 | T1178 | T1176 | appos | p52,p50 |
R807 | T1179 | T1176 | punct | ",",p50 |
R808 | T1180 | T1176 | conj | c-Rel,p50 |
R809 | T1181 | T1180 | cc | and,c-Rel |
R810 | T1182 | T1180 | conj | RelB,c-Rel |
R811 | T1183 | T1166 | punct | .,are |
R812 | T1184 | T1188 | det | The,complex |
R813 | T1185 | T1186 | advmod | most,common |
R814 | T1186 | T1188 | amod | common,complex |
R815 | T1187 | T1188 | compound | activating,complex |
R816 | T1188 | T1189 | nsubj | complex,is |
R817 | T1189 | T1189 | ROOT | is,is |
R818 | T1190 | T1192 | det | the,heterodimer |
R819 | T1191 | T1192 | nummod | p50/p65,heterodimer |
R820 | T1192 | T1189 | attr | heterodimer,is |
R821 | T1193 | T1192 | punct | ",",heterodimer |
R822 | T1194 | T1192 | acl | driven,heterodimer |
R823 | T1195 | T1194 | agent | by,driven |
R824 | T1196 | T1198 | det | the,domain |
R825 | T1197 | T1198 | compound | activation,domain |
R826 | T1198 | T1195 | pobj | domain,by |
R827 | T1199 | T1198 | prep | in,domain |
R828 | T1200 | T1203 | det | the,subunit |
R829 | T1201 | T1203 | nmod | NF-κB,subunit |
R830 | T1202 | T1203 | nummod | p65,subunit |
R831 | T1203 | T1199 | pobj | subunit,in |
R832 | T1204 | T1189 | punct | .,is |
R833 | T1205 | T1207 | nsubj | NF-κB,regulates |
R834 | T1206 | T1205 | nummod | p65,NF-κB |
R835 | T1207 | T1207 | ROOT | regulates,regulates |
R836 | T1208 | T1210 | amod | important,processes |
R837 | T1209 | T1210 | amod | developmental,processes |
R838 | T1210 | T1207 | dobj | processes,regulates |
R839 | T1211 | T1213 | nmod | [,] |
R840 | T1212 | T1213 | nummod | 9,] |
R841 | T1213 | T1217 | nmod | ],] |
R842 | T1214 | T1213 | punct | ",",] |
R843 | T1215 | T1217 | nmod | [,] |
R844 | T1216 | T1217 | nummod | 10,] |
R845 | T1217 | T1207 | npadvmod | ],regulates |
R846 | T1218 | T1207 | punct | .,regulates |
R847 | T1219 | T1219 | ROOT | Mice,Mice |
R848 | T1220 | T1219 | acl | lacking,Mice |
R849 | T1221 | T1223 | nsubj | NF-κB,die |
R850 | T1222 | T1223 | nummod | p65,die |
R851 | T1223 | T1220 | dep | die,lacking |
R852 | T1224 | T1223 | prep | in,die |
R853 | T1225 | T1224 | pobj | utero,in |
R854 | T1226 | T1223 | cc | and,die |
R855 | T1227 | T1223 | conj | have,die |
R856 | T1228 | T1230 | amod | extensive,damage |
R857 | T1229 | T1230 | compound | liver,damage |
R858 | T1230 | T1227 | dobj | damage,have |
R859 | T1231 | T1230 | prep | via,damage |
R860 | T1232 | T1234 | amod | enhanced,[ |
R861 | T1233 | T1234 | compound | apoptosis,[ |
R862 | T1234 | T1231 | pobj | [,via |
R863 | T1235 | T1236 | nummod | 9,] |
R864 | T1236 | T1230 | appos | ],damage |
R865 | T1237 | T1220 | punct | .,lacking |
R866 | T1238 | T1239 | amod | Embryonic,macrophages |
R867 | T1239 | T1245 | nsubj | macrophages,are |
R868 | T1240 | T1239 | prep | from,macrophages |
R869 | T1241 | T1244 | nmod | NF-κB,mice |
R870 | T1242 | T1241 | nummod | p65,NF-κB |
R871 | T1243 | T1244 | amod | null,mice |
R872 | T1244 | T1240 | pobj | mice,from |
R873 | T1245 | T1245 | ROOT | are,are |
R874 | T1246 | T1245 | acomp | susceptible,are |
R875 | T1247 | T1246 | prep | to,susceptible |
R876 | T1248 | T1249 | amod | TNFα-induced,apoptosis |
R877 | T1249 | T1247 | pobj | apoptosis,to |
R878 | T1250 | T1252 | nsubjpass | which,rescued |
R879 | T1251 | T1252 | auxpass | is,rescued |
R880 | T1252 | T1249 | relcl | rescued,apoptosis |
R881 | T1253 | T1252 | agent | by,rescued |
R882 | T1254 | T1253 | pcomp | overexpressing,by |
R883 | T1255 | T1259 | det | the,[ |
R884 | T1256 | T1259 | nmod | NF-κB,[ |
R885 | T1257 | T1256 | nummod | p65,NF-κB |
R886 | T1258 | T1259 | amod | subunit,[ |
R887 | T1259 | T1254 | dobj | [,overexpressing |
R888 | T1260 | T1261 | nummod | 10,] |
R889 | T1261 | T1254 | dobj | ],overexpressing |
R890 | T1262 | T1245 | punct | .,are |
R891 | T1263 | T1267 | advmod | Moreover,induces |
R892 | T1264 | T1267 | punct | ",",induces |
R893 | T1265 | T1267 | csubj | inhibiting,induces |
R894 | T1266 | T1267 | nsubj | NF-κB,induces |
R895 | T1267 | T1267 | ROOT | induces,induces |
R896 | T1268 | T1269 | compound | cell,death |
R897 | T1269 | T1267 | dobj | death,induces |
R898 | T1270 | T1267 | prep | in,induces |
R899 | T1271 | T1273 | amod | many,types |
R900 | T1272 | T1273 | compound | cell,types |
R901 | T1273 | T1270 | pobj | types,in |
R902 | T1274 | T1273 | cc | and,types |
R903 | T1275 | T1276 | amod | cytokine-independent,survival |
R904 | T1276 | T1273 | conj | survival,types |
R905 | T1277 | T1278 | auxpass | is,mediated |
R906 | T1278 | T1267 | conj | mediated,induces |
R907 | T1279 | T1278 | agent | by,mediated |
R908 | T1280 | T1281 | advmod | constitutively,active |
R909 | T1281 | T1282 | amod | active,NF-κB |
R910 | T1282 | T1279 | pobj | NF-κB,by |
R911 | T1283 | T1282 | prep | in,NF-κB |
R912 | T1284 | T1285 | compound | murine,macrophages |
R913 | T1285 | T1283 | pobj | macrophages,in |
R914 | T1286 | T1288 | quantmod | [,] |
R915 | T1287 | T1288 | nummod | 11,] |
R916 | T1288 | T1282 | appos | ],NF-κB |
R917 | T1289 | T1267 | punct | .,induces |
R918 | T1290 | T1296 | prep | In,is |
R919 | T1291 | T1290 | pobj | monocytes,In |
R920 | T1292 | T1291 | cc | and,monocytes |
R921 | T1293 | T1291 | conj | macrophages,monocytes |
R922 | T1294 | T1296 | punct | ",",is |
R923 | T1295 | T1296 | nsubj | NF-κB,is |
R924 | T1296 | T1296 | ROOT | is,is |
R925 | T1297 | T1300 | det | an,factor |
R926 | T1298 | T1300 | amod | important,factor |
R927 | T1299 | T1300 | amod | transcriptional,factor |
R928 | T1300 | T1296 | attr | factor,is |
R929 | T1301 | T1300 | prep | for,factor |
R930 | T1302 | T1301 | pobj | expression,for |
R931 | T1303 | T1302 | prep | of,expression |
R932 | T1304 | T1303 | pobj | cytokines,of |
R933 | T1305 | T1304 | cc | and,cytokines |
R934 | T1306 | T1307 | compound | cell,surface |
R935 | T1307 | T1308 | compound | surface,receptors |
R936 | T1308 | T1304 | conj | receptors,cytokines |
R937 | T1309 | T1311 | nmod | [,] |
R938 | T1310 | T1311 | nummod | 12,] |
R939 | T1311 | T1300 | appos | ],factor |
R940 | T1312 | T1296 | punct | .,is |
R941 | T1313 | T1320 | advmod | However,is |
R942 | T1314 | T1320 | punct | ",",is |
R943 | T1315 | T1320 | prep | unlike,is |
R944 | T1316 | T1317 | amod | resting,T-cells |
R945 | T1317 | T1315 | pobj | T-cells,unlike |
R946 | T1318 | T1320 | punct | ",",is |
R947 | T1319 | T1320 | nsubj | NF-κB,is |
R948 | T1320 | T1320 | ROOT | is,is |
R949 | T1321 | T1322 | advmod | constitutively,present |
R950 | T1322 | T1320 | acomp | present,is |
R951 | T1323 | T1322 | prep | in,present |
R952 | T1324 | T1325 | det | the,nuclei |
R953 | T1325 | T1323 | pobj | nuclei,in |
R954 | T1326 | T1325 | prep | of,nuclei |
R955 | T1327 | T1328 | amod | primary,monocytes |
R956 | T1328 | T1326 | pobj | monocytes,of |
R957 | T1329 | T1328 | cc | and,monocytes |
R958 | T1330 | T1332 | amod | monocytic,lines |
R959 | T1331 | T1332 | compound | cell,lines |
R960 | T1332 | T1328 | conj | lines,monocytes |
R961 | T1333 | T1322 | prep | in,present |
R962 | T1334 | T1335 | det | the,absence |
R963 | T1335 | T1333 | pobj | absence,in |
R964 | T1336 | T1335 | prep | of,absence |
R965 | T1337 | T1338 | amod | exogenous,stimuli |
R966 | T1338 | T1336 | pobj | stimuli,of |
R967 | T1339 | T1340 | mark | as,demonstrated |
R968 | T1340 | T1322 | advcl | demonstrated,present |
R969 | T1341 | T1340 | agent | by,demonstrated |
R970 | T1342 | T1343 | compound | mobility,shift |
R971 | T1343 | T1344 | compound | shift,analysis |
R972 | T1344 | T1345 | compound | analysis,[ |
R973 | T1345 | T1347 | nmod | [,] |
R974 | T1346 | T1347 | nummod | 13,] |
R975 | T1347 | T1341 | pobj | ],by |
R976 | T1348 | T1320 | punct | .,is |
R977 | T1349 | T1355 | advmod | Similarly,observed |
R978 | T1350 | T1355 | punct | ",",observed |
R979 | T1351 | T1352 | advmod | constitutively,active |
R980 | T1352 | T1353 | amod | active,NF-κB |
R981 | T1353 | T1355 | nsubjpass | NF-κB,observed |
R982 | T1354 | T1355 | auxpass | was,observed |
R983 | T1355 | T1355 | ROOT | observed,observed |
R984 | T1356 | T1355 | prep | in,observed |
R985 | T1357 | T1359 | amod | human,macrophages |
R986 | T1358 | T1359 | amod | alveolar,macrophages |
R987 | T1359 | T1356 | pobj | macrophages,in |
R988 | T1360 | T1362 | nmod | [,] |
R989 | T1361 | T1362 | nummod | 14,] |
R990 | T1362 | T1355 | dobj | ],observed |
R991 | T1363 | T1355 | punct | .,observed |
R992 | T1364 | T1374 | prep | In,sequestered |
R993 | T1365 | T1367 | det | the,pathway |
R994 | T1366 | T1367 | amod | classic/canonical,pathway |
R995 | T1367 | T1364 | pobj | pathway,In |
R996 | T1368 | T1374 | punct | ",",sequestered |
R997 | T1369 | T1374 | det | the,sequestered |
R998 | T1370 | T1374 | nsubjpass | NF-κB,sequestered |
R999 | T1371 | T1372 | nummod | p50/p65,complex |
R1000 | T1372 | T1374 | nsubjpass | complex,sequestered |
R1001 | T1373 | T1374 | auxpass | is,sequestered |
R1002 | T1374 | T1374 | ROOT | sequestered,sequestered |
R1003 | T1375 | T1374 | prep | in,sequestered |
R1004 | T1376 | T1377 | det | the,cytosol |
R1005 | T1377 | T1375 | pobj | cytosol,in |
R1006 | T1378 | T1374 | agent | by,sequestered |
R1007 | T1379 | T1380 | compound | IκBα,[ |
R1008 | T1380 | T1378 | pobj | [,by |
R1009 | T1381 | T1382 | nummod | 15,] |
R1010 | T1382 | T1380 | appos | ],[ |
R1011 | T1383 | T1374 | punct | .,sequestered |
R1012 | T1384 | T1394 | mark | Upon,phosphorylated |
R1013 | T1385 | T1384 | pobj | stimulation,Upon |
R1014 | T1386 | T1385 | prep | by,stimulation |
R1015 | T1387 | T1386 | pobj | cytokines,by |
R1016 | T1388 | T1387 | cc | or,cytokines |
R1017 | T1389 | T1390 | compound | UV,radiation |
R1018 | T1390 | T1387 | conj | radiation,cytokines |
R1019 | T1391 | T1390 | punct | ",",radiation |
R1020 | T1392 | T1393 | nsubj | IκBα,is |
R1021 | T1393 | T1394 | auxpass | is,phosphorylated |
R1022 | T1394 | T1394 | ROOT | phosphorylated,phosphorylated |
R1023 | T1395 | T1394 | punct | ",",phosphorylated |
R1024 | T1396 | T1394 | conj | ubiquitinated,phosphorylated |
R1025 | T1397 | T1396 | punct | ",",ubiquitinated |
R1026 | T1398 | T1396 | cc | and,ubiquitinated |
R1027 | T1399 | T1396 | conj | degraded,ubiquitinated |
R1028 | T1400 | T1394 | punct | ",",phosphorylated |
R1029 | T1401 | T1394 | advcl | releasing,phosphorylated |
R1030 | T1402 | T1403 | compound | NF-κB,p50/p65 |
R1031 | T1403 | T1401 | dobj | p50/p65,releasing |
R1032 | T1404 | T1405 | aux | to,translocate |
R1033 | T1405 | T1401 | advcl | translocate,releasing |
R1034 | T1406 | T1405 | prep | to,translocate |
R1035 | T1407 | T1408 | det | the,nucleus |
R1036 | T1408 | T1406 | pobj | nucleus,to |
R1037 | T1409 | T1408 | cc | and,nucleus |
R1038 | T1410 | T1412 | compound | transactivate,genes |
R1039 | T1411 | T1412 | compound | target,genes |
R1040 | T1412 | T1408 | conj | genes,nucleus |
R1041 | T1413 | T1394 | punct | .,phosphorylated |
R1042 | T1414 | T1423 | prep | After,undergo |
R1043 | T1415 | T1416 | poss | its,release |
R1044 | T1416 | T1414 | pobj | release,After |
R1045 | T1417 | T1416 | prep | from,release |
R1046 | T1418 | T1417 | pobj | IκBα,from |
R1047 | T1419 | T1418 | punct | ",",IκBα |
R1048 | T1420 | T1421 | compound | NF-κB,p65 |
R1049 | T1421 | T1423 | nsubj | p65,undergo |
R1050 | T1422 | T1423 | aux | can,undergo |
R1051 | T1423 | T1423 | ROOT | undergo,undergo |
R1052 | T1424 | T1425 | amod | post-translational,modification |
R1053 | T1425 | T1423 | dobj | modification,undergo |
R1054 | T1426 | T1427 | aux | to,activate |
R1055 | T1427 | T1423 | xcomp | activate,undergo |
R1056 | T1428 | T1429 | compound | gene,transcription |
R1057 | T1429 | T1427 | dobj | transcription,activate |
R1058 | T1430 | T1423 | punct | .,undergo |
R1059 | T1431 | T1432 | det | The,role |
R1060 | T1432 | T1441 | nsubj | role,varies |
R1061 | T1433 | T1432 | prep | of,role |
R1062 | T1434 | T1433 | pobj | NF-κB,of |
R1063 | T1435 | T1436 | nummod | p65,phosphorylation |
R1064 | T1436 | T1441 | nsubj | phosphorylation,varies |
R1065 | T1437 | T1436 | prep | on,phosphorylation |
R1066 | T1438 | T1440 | amod | NF-κB,activity |
R1067 | T1439 | T1440 | amod | transcriptional,activity |
R1068 | T1440 | T1437 | pobj | activity,on |
R1069 | T1441 | T1441 | ROOT | varies,varies |
R1070 | T1442 | T1441 | prep | by,varies |
R1071 | T1443 | T1442 | pobj | stimulus,by |
R1072 | T1444 | T1453 | punct | ",",] |
R1073 | T1445 | T1453 | npadvmod | time,] |
R1074 | T1446 | T1445 | prep | of,time |
R1075 | T1447 | T1446 | pobj | stimulation,of |
R1076 | T1448 | T1447 | cc | and,stimulation |
R1077 | T1449 | T1450 | compound | cell,type |
R1078 | T1450 | T1447 | conj | type,stimulation |
R1079 | T1451 | T1453 | nmod | [,] |
R1080 | T1452 | T1453 | nummod | 16,] |
R1081 | T1453 | T1441 | npadvmod | ],varies |
R1082 | T1454 | T1441 | punct | .,varies |
R1083 | T1455 | T1456 | amod | Previous,research |
R1084 | T1456 | T1457 | nsubj | research,shows |
R1085 | T1457 | T1457 | ROOT | shows,shows |
R1086 | T1458 | T1469 | mark | that,plays |
R1087 | T1459 | T1469 | nsubj | phosphorylation,plays |
R1088 | T1460 | T1459 | prep | of,phosphorylation |
R1089 | T1461 | T1462 | compound | NF-κB,p65 |
R1090 | T1462 | T1460 | pobj | p65,of |
R1091 | T1463 | T1459 | prep | at,phosphorylation |
R1092 | T1464 | T1463 | pobj | Ser276,at |
R1093 | T1465 | T1464 | punct | ",",Ser276 |
R1094 | T1466 | T1464 | conj | Ser529,Ser276 |
R1095 | T1467 | T1466 | cc | or,Ser529 |
R1096 | T1468 | T1466 | conj | Ser536,Ser529 |
R1097 | T1469 | T1457 | ccomp | plays,shows |
R1098 | T1470 | T1472 | det | an,role |
R1099 | T1471 | T1472 | amod | important,role |
R1100 | T1472 | T1469 | dobj | role,plays |
R1101 | T1473 | T1472 | prep | in,role |
R1102 | T1474 | T1473 | pcomp | regulating,in |
R1103 | T1475 | T1476 | amod | transcriptional,activity |
R1104 | T1476 | T1474 | dobj | activity,regulating |
R1105 | T1477 | T1476 | prep | of,activity |
R1106 | T1478 | T1479 | compound | NF-κB,[ |
R1107 | T1479 | T1477 | pobj | [,of |
R1108 | T1480 | T1481 | nummod | 17,] |
R1109 | T1481 | T1474 | dobj | ],regulating |
R1110 | T1482 | T1457 | punct | .,shows |
R1111 | T1483 | T1493 | prep | In,phosphorylated |
R1112 | T1484 | T1486 | amod | TNFα-treated,fibroblasts |
R1113 | T1485 | T1486 | compound | murine,fibroblasts |
R1114 | T1486 | T1483 | pobj | fibroblasts,In |
R1115 | T1487 | T1493 | punct | ",",phosphorylated |
R1116 | T1488 | T1493 | nsubjpass | Ser276,phosphorylated |
R1117 | T1489 | T1488 | prep | of,Ser276 |
R1118 | T1490 | T1489 | pobj | NF-κB,of |
R1119 | T1491 | T1490 | nummod | p65,NF-κB |
R1120 | T1492 | T1493 | auxpass | is,phosphorylated |
R1121 | T1493 | T1493 | ROOT | phosphorylated,phosphorylated |
R1122 | T1494 | T1493 | agent | by,phosphorylated |
R1123 | T1495 | T1494 | pobj | MSK1,by |
R1124 | T1496 | T1497 | aux | to,enhance |
R1125 | T1497 | T1493 | advcl | enhance,phosphorylated |
R1126 | T1498 | T1500 | amod | NF-κB,activity |
R1127 | T1499 | T1500 | amod | transcriptional,activity |
R1128 | T1500 | T1497 | dobj | activity,enhance |
R1129 | T1501 | T1503 | nmod | [,] |
R1130 | T1502 | T1503 | nummod | 18,] |
R1131 | T1503 | T1500 | appos | ],activity |
R1132 | T1504 | T1493 | punct | .,phosphorylated |
R1133 | T1505 | T1515 | prep | In,associated |
R1134 | T1506 | T1505 | pobj | macrophages,In |
R1135 | T1507 | T1506 | acl | treated,macrophages |
R1136 | T1508 | T1507 | prep | with,treated |
R1137 | T1509 | T1508 | pobj | endotoxin,with |
R1138 | T1510 | T1515 | punct | ",",associated |
R1139 | T1511 | T1513 | amod | NF-κB,activity |
R1140 | T1512 | T1513 | compound | transcription,activity |
R1141 | T1513 | T1515 | nsubjpass | activity,associated |
R1142 | T1514 | T1515 | auxpass | is,associated |
R1143 | T1515 | T1515 | ROOT | associated,associated |
R1144 | T1516 | T1515 | prep | with,associated |
R1145 | T1517 | T1516 | pobj | phosphorylation,with |
R1146 | T1518 | T1517 | prep | on,phosphorylation |
R1147 | T1519 | T1518 | pobj | Ser276,on |
R1148 | T1520 | T1519 | cc | and,Ser276 |
R1149 | T1521 | T1519 | conj | Ser536,Ser276 |
R1150 | T1522 | T1524 | nsubjpass | that,regulated |
R1151 | T1523 | T1524 | auxpass | is,regulated |
R1152 | T1524 | T1515 | conj | regulated,associated |
R1153 | T1525 | T1524 | prep | through,regulated |
R1154 | T1526 | T1525 | pobj | protein,through |
R1155 | T1527 | T1528 | compound | kinase,A |
R1156 | T1528 | T1530 | det | A,PKA |
R1157 | T1529 | T1530 | punct | (,PKA |
R1158 | T1530 | T1524 | oprd | PKA,regulated |
R1159 | T1531 | T1530 | punct | ),PKA |
R1160 | T1532 | T1530 | cc | and,PKA |
R1161 | T1533 | T1530 | conj | IKKβ,PKA |
R1162 | T1534 | T1535 | compound | respectively,[ |
R1163 | T1535 | T1530 | conj | [,PKA |
R1164 | T1536 | T1535 | nummod | 16,[ |
R1165 | T1537 | T1535 | conj | ],[ |
R1166 | T1538 | T1537 | punct | ",",] |
R1167 | T1539 | T1535 | conj | [,[ |
R1168 | T1540 | T1539 | nummod | 19,[ |
R1169 | T1541 | T1535 | conj | ],[ |
R1170 | T1542 | T1515 | punct | .,associated |
R1171 | T1543 | T1550 | prep | In,is |
R1172 | T1544 | T1546 | amod | human,cells |
R1173 | T1545 | T1546 | compound | T,cells |
R1174 | T1546 | T1543 | pobj | cells,In |
R1175 | T1547 | T1550 | punct | ",",is |
R1176 | T1548 | T1549 | compound | NF-κB,p65 |
R1177 | T1549 | T1550 | nsubj | p65,is |
R1178 | T1550 | T1550 | ROOT | is,is |
R1179 | T1551 | T1552 | advmod | constitutively,phosphorylated |
R1180 | T1552 | T1550 | acomp | phosphorylated,is |
R1181 | T1553 | T1552 | prep | on,phosphorylated |
R1182 | T1554 | T1553 | pobj | Ser536,on |
R1183 | T1555 | T1556 | aux | to,facilitate |
R1184 | T1556 | T1552 | xcomp | facilitate,phosphorylated |
R1185 | T1557 | T1560 | nmod | NF-κB,translocation |
R1186 | T1558 | T1557 | nummod | p65,NF-κB |
R1187 | T1559 | T1560 | amod | nuclear,translocation |
R1188 | T1560 | T1556 | dobj | translocation,facilitate |
R1189 | T1561 | T1560 | prep | following,translocation |
R1190 | T1562 | T1563 | amod | cellular,stimulation |
R1191 | T1563 | T1561 | pobj | stimulation,following |
R1192 | T1564 | T1566 | nmod | [,] |
R1193 | T1565 | T1566 | nummod | 20,] |
R1194 | T1566 | T1563 | appos | ],stimulation |
R1195 | T1567 | T1550 | punct | .,is |
R1196 | T1568 | T1569 | amod | Accumulating,evidence |
R1197 | T1569 | T1570 | nsubj | evidence,reveals |
R1198 | T1570 | T1570 | ROOT | reveals,reveals |
R1199 | T1571 | T1577 | mark | that,is |
R1200 | T1572 | T1577 | nsubj | NF-κB,is |
R1201 | T1573 | T1574 | nummod | p65,phosphorylation |
R1202 | T1574 | T1577 | nsubj | phosphorylation,is |
R1203 | T1575 | T1574 | prep | at,phosphorylation |
R1204 | T1576 | T1575 | pobj | Ser276,at |
R1205 | T1577 | T1570 | ccomp | is,reveals |
R1206 | T1578 | T1577 | acomp | crucial,is |
R1207 | T1579 | T1578 | prep | for,crucial |
R1208 | T1580 | T1582 | poss | its,activity |
R1209 | T1581 | T1582 | amod | transcriptional,activity |
R1210 | T1582 | T1579 | pobj | activity,for |
R1211 | T1583 | T1570 | punct | .,reveals |
R1212 | T1584 | T1596 | prep | Upon,recruits |
R1213 | T1585 | T1586 | amod | nuclear,translocation |
R1214 | T1586 | T1584 | pobj | translocation,Upon |
R1215 | T1587 | T1596 | punct | ",",recruits |
R1216 | T1588 | T1596 | nsubj | phosphorylation,recruits |
R1217 | T1589 | T1588 | prep | of,phosphorylation |
R1218 | T1590 | T1589 | pobj | Ser276,of |
R1219 | T1591 | T1588 | prep | on,phosphorylation |
R1220 | T1592 | T1591 | pobj | NF-κB,on |
R1221 | T1593 | T1588 | dep | p65,phosphorylation |
R1222 | T1594 | T1588 | prep | by,phosphorylation |
R1223 | T1595 | T1594 | pobj | PKA,by |
R1224 | T1596 | T1596 | ROOT | recruits,recruits |
R1225 | T1597 | T1599 | det | the,co-activator |
R1226 | T1598 | T1599 | compound | transcription,co-activator |
R1227 | T1599 | T1596 | dobj | co-activator,recruits |
R1228 | T1600 | T1599 | punct | ",",co-activator |
R1229 | T1601 | T1599 | appos | p300,co-activator |
R1230 | T1602 | T1603 | aux | to,potentiate |
R1231 | T1603 | T1596 | advcl | potentiate,recruits |
R1232 | T1604 | T1606 | amod | NF-κB-regulated,transcription |
R1233 | T1605 | T1606 | compound | gene,transcription |
R1234 | T1606 | T1603 | dobj | transcription,potentiate |
R1235 | T1607 | T1609 | nmod | [,] |
R1236 | T1608 | T1609 | nummod | 21,] |
R1237 | T1609 | T1609 | ROOT | ],] |
R1238 | T1610 | T1596 | punct | .,recruits |
R1239 | T1611 | T1615 | advmod | However,show |
R1240 | T1612 | T1615 | punct | ",",show |
R1241 | T1613 | T1614 | amod | other,studies |
R1242 | T1614 | T1615 | nsubj | studies,show |
R1243 | T1615 | T1615 | ROOT | show,show |
R1244 | T1616 | T1618 | mark | that,inhibits |
R1245 | T1617 | T1618 | nsubj | PKA,inhibits |
R1246 | T1618 | T1615 | ccomp | inhibits,show |
R1247 | T1619 | T1621 | amod | NF-κB-regulated,expression |
R1248 | T1620 | T1621 | compound | gene,expression |
R1249 | T1621 | T1618 | dobj | expression,inhibits |
R1250 | T1622 | T1618 | prep | by,inhibits |
R1251 | T1623 | T1622 | pcomp | stabilizing,by |
R1252 | T1624 | T1625 | compound | IκBα,[ |
R1253 | T1625 | T1623 | dobj | [,stabilizing |
R1254 | T1626 | T1627 | nummod | 22,] |
R1255 | T1627 | T1623 | dobj | ],stabilizing |
R1256 | T1628 | T1629 | punct | ",",[ |
R1257 | T1629 | T1627 | npadvmod | [,] |
R1258 | T1630 | T1631 | nummod | 23,] |
R1259 | T1631 | T1627 | conj | ],] |
R1260 | T1632 | T1615 | punct | .,show |
R1261 | T1633 | T1640 | advmod | Interestingly,phosphorylates |
R1262 | T1634 | T1640 | punct | ",",phosphorylates |
R1263 | T1635 | T1638 | det | the,Pim-1 |
R1264 | T1636 | T1638 | amod | serine/threonine,Pim-1 |
R1265 | T1637 | T1638 | compound | kinase,Pim-1 |
R1266 | T1638 | T1640 | nsubj | Pim-1,phosphorylates |
R1267 | T1639 | T1640 | advmod | directly,phosphorylates |
R1268 | T1640 | T1640 | ROOT | phosphorylates,phosphorylates |
R1269 | T1641 | T1642 | compound | NF-κB,p65 |
R1270 | T1642 | T1640 | dobj | p65,phosphorylates |
R1271 | T1643 | T1640 | prep | at,phosphorylates |
R1272 | T1644 | T1643 | pobj | Ser276,at |
R1273 | T1645 | T1640 | prep | by,phosphorylates |
R1274 | T1646 | T1645 | pcomp | stabilizing,by |
R1275 | T1647 | T1648 | aux | to,prevent |
R1276 | T1648 | T1646 | xcomp | prevent,stabilizing |
R1277 | T1649 | T1650 | amod | ubiquitin-proteasome,degradation |
R1278 | T1650 | T1648 | dobj | degradation,prevent |
R1279 | T1651 | T1653 | nmod | [,] |
R1280 | T1652 | T1653 | nummod | 24,] |
R1281 | T1653 | T1650 | appos | ],degradation |
R1282 | T1654 | T1640 | punct | .,phosphorylates |
R1283 | T1655 | T1658 | amod | Several,sites |
R1284 | T1656 | T1658 | amod | other,sites |
R1285 | T1657 | T1658 | amod | phosphorylation,sites |
R1286 | T1658 | T1661 | nsubjpass | sites,described |
R1287 | T1659 | T1661 | auxpass | are,described |
R1288 | T1660 | T1661 | advmod | also,described |
R1289 | T1661 | T1661 | ROOT | described,described |
R1290 | T1662 | T1663 | aux | to,enhance |
R1291 | T1663 | T1661 | xcomp | enhance,described |
R1292 | T1664 | T1666 | amod | NF-κB,transactivation |
R1293 | T1665 | T1666 | compound | gene,transactivation |
R1294 | T1666 | T1663 | dobj | transactivation,enhance |
R1295 | T1667 | T1669 | nmod | [,] |
R1296 | T1668 | T1669 | nummod | 25,] |
R1297 | T1669 | T1666 | appos | ],transactivation |
R1298 | T1670 | T1661 | punct | .,described |
R1299 | T1671 | T1674 | advmod | Here,investigate |
R1300 | T1672 | T1674 | punct | ",",investigate |
R1301 | T1673 | T1674 | nsubj | we,investigate |
R1302 | T1674 | T1674 | ROOT | investigate,investigate |
R1303 | T1675 | T1676 | det | the,role |
R1304 | T1676 | T1674 | dobj | role,investigate |
R1305 | T1677 | T1676 | prep | of,role |
R1306 | T1678 | T1677 | pobj | protein,of |
R1307 | T1679 | T1680 | compound | kinase,C |
R1308 | T1680 | T1680 | ROOT | C,C |
R1309 | T1681 | T1680 | punct | (,C |
R1310 | T1682 | T1680 | appos | PKC,C |
R1311 | T1683 | T1680 | punct | ),C |
R1312 | T1684 | T1676 | prep | in,role |
R1313 | T1685 | T1686 | compound | M-CSF-stimulated,NF-κB |
R1314 | T1686 | T1687 | compound | NF-κB,activation |
R1315 | T1687 | T1684 | pobj | activation,in |
R1316 | T1688 | T1674 | punct | .,investigate |
R1317 | T1689 | T1690 | compound | PKC,proteins |
R1318 | T1690 | T1691 | nsubj | proteins,are |
R1319 | T1691 | T1691 | ROOT | are,are |
R1320 | T1692 | T1693 | amod | multifunctional,kinases |
R1321 | T1693 | T1691 | attr | kinases,are |
R1322 | T1694 | T1695 | nsubj | that,differ |
R1323 | T1695 | T1693 | relcl | differ,kinases |
R1324 | T1696 | T1695 | prep | in,differ |
R1325 | T1697 | T1696 | pobj | structure,in |
R1326 | T1698 | T1697 | punct | ",",structure |
R1327 | T1699 | T1695 | npadvmod | function,differ |
R1328 | T1700 | T1699 | cc | and,function |
R1329 | T1701 | T1699 | conj | co-factor,function |
R1330 | T1702 | T1705 | compound | requirement,] |
R1331 | T1703 | T1705 | nmod | [,] |
R1332 | T1704 | T1705 | nummod | 26,] |
R1333 | T1705 | T1693 | appos | ],kinases |
R1334 | T1706 | T1691 | punct | .,are |
R1335 | T1707 | T1709 | nsubjpass | PKCs,involved |
R1336 | T1708 | T1709 | auxpass | are,involved |
R1337 | T1709 | T1709 | ROOT | involved,involved |
R1338 | T1710 | T1709 | prep | in,involved |
R1339 | T1711 | T1713 | amod | diverse,responses |
R1340 | T1712 | T1713 | compound | cell,responses |
R1341 | T1713 | T1710 | pobj | responses,in |
R1342 | T1714 | T1713 | punct | ",",responses |
R1343 | T1715 | T1713 | prep | including,responses |
R1344 | T1716 | T1717 | compound | cell,growth |
R1345 | T1717 | T1715 | pobj | growth,including |
R1346 | T1718 | T1717 | punct | ",",growth |
R1347 | T1719 | T1717 | conj | survival,growth |
R1348 | T1720 | T1719 | punct | ",",survival |
R1349 | T1721 | T1719 | conj | differentiation,survival |
R1350 | T1722 | T1721 | cc | and,differentiation |
R1351 | T1723 | T1721 | conj | development,differentiation |
R1352 | T1724 | T1726 | nmod | [,] |
R1353 | T1725 | T1726 | nummod | 27,] |
R1354 | T1726 | T1717 | appos | ],growth |
R1355 | T1727 | T1709 | punct | .,involved |
R1356 | T1728 | T1732 | det | The,enzymes |
R1357 | T1729 | T1732 | nummod | 12,enzymes |
R1358 | T1730 | T1731 | advmod | closely,related |
R1359 | T1731 | T1732 | amod | related,enzymes |
R1360 | T1732 | T1738 | nsubjpass | enzymes,divided |
R1361 | T1733 | T1732 | prep | of,enzymes |
R1362 | T1734 | T1736 | det | the,family |
R1363 | T1735 | T1736 | compound | PKC,family |
R1364 | T1736 | T1733 | pobj | family,of |
R1365 | T1737 | T1738 | auxpass | are,divided |
R1366 | T1738 | T1738 | ROOT | divided,divided |
R1367 | T1739 | T1738 | prep | into,divided |
R1368 | T1740 | T1741 | nummod | three,classes |
R1369 | T1741 | T1739 | pobj | classes,into |
R1370 | T1742 | T1741 | punct | :,classes |
R1371 | T1743 | T1741 | appos | conventional,classes |
R1372 | T1744 | T1747 | punct | (,α |
R1373 | T1745 | T1747 | dep | cPKCs,α |
R1374 | T1746 | T1747 | punct | :,α |
R1375 | T1747 | T1752 | nsubj | α,require |
R1376 | T1748 | T1749 | compound | βI,βII |
R1377 | T1749 | T1752 | nsubj | βII,require |
R1378 | T1750 | T1749 | cc | and,βII |
R1379 | T1751 | T1749 | conj | γ,βII |
R1380 | T1752 | T1738 | advcl | require,divided |
R1381 | T1753 | T1754 | amod | Ca2,+ |
R1382 | T1754 | T1752 | dobj | +,require |
R1383 | T1755 | T1754 | cc | and,+ |
R1384 | T1756 | T1754 | conj | diacylglycerol,+ |
R1385 | T1757 | T1758 | punct | (,DAG |
R1386 | T1758 | T1756 | appos | DAG,diacylglycerol |
R1387 | T1759 | T1756 | punct | ),diacylglycerol |
R1388 | T1760 | T1752 | punct | ;,require |
R1389 | T1761 | T1752 | conj | novel,require |
R1390 | T1762 | T1765 | punct | (,δ |
R1391 | T1763 | T1765 | dep | nPKCs,δ |
R1392 | T1764 | T1765 | punct | :,δ |
R1393 | T1765 | T1761 | appos | δ,novel |
R1394 | T1766 | T1765 | punct | ",",δ |
R1395 | T1767 | T1765 | dep | ε,δ |
R1396 | T1768 | T1767 | punct | ",",ε |
R1397 | T1769 | T1765 | dep | η,δ |
R1398 | T1770 | T1769 | punct | ",",η |
R1399 | T1771 | T1769 | dep | θ,η |
R1400 | T1772 | T1771 | cc | and,θ |
R1401 | T1773 | T1771 | conj | μ,θ |
R1402 | T1774 | T1773 | punct | ),μ |
R1403 | T1775 | T1765 | dep | require,δ |
R1404 | T1776 | T1775 | dobj | DAG,require |
R1405 | T1777 | T1765 | punct | ;,δ |
R1406 | T1778 | T1765 | cc | and,δ |
R1407 | T1843 | T1844 | compound | TNFα,mRNA |
R1408 | T1779 | T1765 | conj | atypical,δ |
R1409 | T1780 | T1789 | punct | (,require |
R1410 | T1844 | T1841 | conj | mRNA,iNOS |
R1411 | T1781 | T1789 | nsubj | aPKCs,require |
R1412 | T1845 | T1838 | dobj | production,induces |
R1413 | T1846 | T1838 | prep | after,induces |
R1414 | T1847 | T1854 | nmod | lipopolysaccharide,] |
R1415 | T1782 | T1783 | punct | :,ξ |
R1416 | T1848 | T1849 | punct | (,LPS |
R1417 | T1849 | T1847 | appos | LPS,lipopolysaccharide |
R1418 | T1850 | T1849 | punct | ),LPS |
R1419 | T1851 | T1847 | conj | exposure,lipopolysaccharide |
R1420 | T1852 | T1854 | nmod | [,] |
R1421 | T1783 | T1789 | nsubj | ξ,require |
R1422 | T1784 | T1783 | punct | ",",ξ |
R1423 | T1853 | T1854 | nummod | 29,] |
R1424 | T1785 | T1783 | dep | ι,ξ |
R1425 | T1854 | T1846 | pobj | ],after |
R1426 | T1855 | T1838 | punct | .,induces |
R1427 | T1856 | T1861 | prep | In,suggests |
R1428 | T1786 | T1785 | cc | and,ι |
R1429 | T1857 | T1856 | pobj | addition,In |
R1430 | T1858 | T1861 | punct | ",",suggests |
R1431 | T1787 | T1785 | conj | λ,ι |
R1432 | T1859 | T1860 | amod | accumulating,evidence |
R1433 | T1860 | T1861 | nsubj | evidence,suggests |
R1434 | T1861 | T1861 | ROOT | suggests,suggests |
R1435 | T1788 | T1787 | punct | ),λ |
R1436 | T1862 | T1867 | mark | that,have |
R1437 | T1863 | T1864 | amod | conventional,PKCs |
R1438 | T1864 | T1867 | nsubj | PKCs,have |
R1439 | T1789 | T1779 | parataxis | require,atypical |
R1440 | T1865 | T1864 | prep | like,PKCs |
R1441 | T1866 | T1865 | pobj | PKCα,like |
R1442 | T1867 | T1861 | ccomp | have,suggests |
R1443 | T1790 | T1791 | preconj | neither,Ca2 |
R1444 | T1868 | T1869 | amod | anti-apoptotic,functions |
R1445 | T1869 | T1867 | dobj | functions,have |
R1446 | T1870 | T1861 | punct | .,suggests |
R1447 | T1791 | T1792 | intj | Ca2,+ |
R1448 | T1871 | T1876 | prep | For,overexpressed |
R1449 | T1792 | T1789 | dobj | +,require |
R1450 | T1872 | T1871 | pobj | example,For |
R1451 | T1873 | T1876 | punct | ",",overexpressed |
R1452 | T1874 | T1875 | nsubj | PKCα,is |
R1453 | T1875 | T1876 | auxpass | is,overexpressed |
R1454 | T1876 | T1876 | ROOT | overexpressed,overexpressed |
R1455 | T1877 | T1876 | prep | in,overexpressed |
R1456 | T1793 | T1792 | cc | nor,+ |
R1457 | T1878 | T1879 | det | a,variety |
R1458 | T1879 | T1877 | pobj | variety,in |
R1459 | T1880 | T1879 | prep | of,variety |
R1460 | T1881 | T1882 | compound | tumor,cells |
R1461 | T1794 | T1792 | conj | DAG,+ |
R1462 | T1882 | T1880 | pobj | cells,of |
R1463 | T1883 | T1882 | prep | including,cells |
R1464 | T1795 | T1789 | punct | .,require |
R1465 | T1884 | T1883 | pobj | gliomas,including |
R1466 | T1885 | T1884 | punct | ",",gliomas |
R1467 | T1886 | T1884 | conj | liver,gliomas |
R1468 | T1887 | T1886 | punct | ",",liver |
R1469 | T1888 | T1886 | cc | and,liver |
R1470 | T1889 | T1886 | conj | lung,liver |
R1471 | T1890 | T1892 | nmod | [,] |
R1472 | T1796 | T1800 | nsubj | Monocytes,express |
R1473 | T1891 | T1892 | nummod | 30,] |
R1474 | T1892 | T1883 | pobj | ],including |
R1475 | T1893 | T1892 | punct | ",",] |
R1476 | T1797 | T1796 | cc | and,Monocytes |
R1477 | T1894 | T1896 | nmod | [,] |
R1478 | T1895 | T1896 | nummod | 31,] |
R1479 | T1896 | T1892 | conj | ],] |
R1480 | T1798 | T1796 | conj | macrophages,Monocytes |
R1481 | T1897 | T1876 | punct | .,overexpressed |
R1482 | T1898 | T1905 | prep | In,induces |
R1483 | T1799 | T1800 | advmod | predominantly,express |
R1484 | T1899 | T1900 | amod | epithelial,cells |
R1485 | T1900 | T1898 | pobj | cells,In |
R1486 | T1901 | T1905 | punct | ",",induces |
R1487 | T1800 | T1800 | ROOT | express,express |
R1488 | T1902 | T1905 | nsubj | inhibition,induces |
R1489 | T1903 | T1902 | prep | of,inhibition |
R1490 | T1801 | T1803 | amod | conventional,isoforms |
R1491 | T1904 | T1903 | pobj | PKCα,of |
R1492 | T1905 | T1905 | ROOT | induces,induces |
R1493 | T1906 | T1907 | amod | PKCδ-dependent,apoptosis |
R1494 | T1802 | T1803 | compound | PKC,isoforms |
R1495 | T1803 | T1800 | dobj | isoforms,express |
R1496 | T1907 | T1908 | compound | apoptosis,[ |
R1497 | T1804 | T1803 | punct | (,isoforms |
R1498 | T1908 | T1905 | dobj | [,induces |
R1499 | T1909 | T1910 | nummod | 31,] |
R1500 | T1805 | T1806 | compound | PKCα,PKCβI |
R1501 | T1910 | T1908 | appos | ],[ |
R1502 | T1911 | T1905 | punct | .,induces |
R1503 | T1912 | T1927 | advmod | Interestingly,have |
R1504 | T1913 | T1927 | punct | ",",have |
R1505 | T1806 | T1803 | appos | PKCβI,isoforms |
R1506 | T1914 | T1927 | prep | in,have |
R1507 | T1915 | T1916 | amod | human,monocytes |
R1508 | T1807 | T1806 | cc | and,PKCβI |
R1509 | T1916 | T1914 | pobj | monocytes,in |
R1510 | T1917 | T1916 | cc | and,monocytes |
R1511 | T1808 | T1806 | conj | PKCβII,PKCβI |
R1512 | T1918 | T1921 | amod | premonocytic,cells |
R1513 | T1919 | T1921 | compound | THP-1,cells |
R1514 | T1920 | T1921 | compound | leukemia,cells |
R1515 | T1809 | T1806 | punct | ),PKCβI |
R1516 | T1921 | T1916 | conj | cells,monocytes |
R1517 | T1922 | T1921 | punct | ",",cells |
R1518 | T1923 | T1924 | compound | novel,PKCs |
R1519 | T1924 | T1921 | conj | PKCs,cells |
R1520 | T1925 | T1924 | prep | like,PKCs |
R1521 | T1926 | T1925 | pobj | PKCδ,like |
R1522 | T1810 | T1806 | cc | and,PKCβI |
R1523 | T1927 | T1938 | ccomp | have,showed |
R1524 | T1928 | T1930 | det | the,effect |
R1525 | T1929 | T1930 | amod | opposite,effect |
R1526 | T1930 | T1927 | dobj | effect,have |
R1527 | T1811 | T1812 | amod | novel,PKCs |
R1528 | T1931 | T1930 | prep | on,effect |
R1529 | T1932 | T1933 | compound | cell,survival |
R1530 | T1933 | T1931 | pobj | survival,on |
R1531 | T1812 | T1806 | conj | PKCs,PKCβI |
R1532 | T1934 | T1938 | punct | ",",showed |
R1533 | T1935 | T1937 | compound | Voss,al |
R1534 | T1813 | T1812 | punct | (,PKCs |
R1535 | T1936 | T1937 | compound | et,al |
R1536 | T1937 | T1938 | nsubj | al,showed |
R1537 | T1938 | T1938 | ROOT | showed,showed |
R1538 | T1939 | T1942 | mark | that,phosphorylates |
R1539 | T1814 | T1812 | conj | PKCδ,PKCs |
R1540 | T1940 | T1942 | nsubj | PKCδ,phosphorylates |
R1541 | T1815 | T1814 | cc | and,PKCδ |
R1542 | T1816 | T1814 | conj | PKCε,PKCδ |
R1543 | T1817 | T1812 | punct | ),PKCs |
R1544 | T1818 | T1800 | punct | .,express |
R1545 | T1941 | T1942 | advmod | directly,phosphorylates |
R1546 | T1942 | T1938 | ccomp | phosphorylates,showed |
R1547 | T1943 | T1942 | dobj | caspase-3,phosphorylates |
R1548 | T1819 | T1820 | amod | Conventional,PKCs |
R1549 | T1944 | T1942 | cc | and,phosphorylates |
R1550 | T1945 | T1942 | conj | promotes,phosphorylates |
R1551 | T1820 | T1821 | nsubj | PKCs,regulate |
R1552 | T1946 | T1947 | amod | etoposide-induced,apoptosis |
R1553 | T1947 | T1948 | compound | apoptosis,[ |
R1554 | T1948 | T1945 | dobj | [,promotes |
R1555 | T1821 | T1821 | ROOT | regulate,regulate |
R1556 | T1949 | T1950 | nummod | 32,] |
R1557 | T1950 | T1948 | appos | ],[ |
R1558 | T1822 | T1821 | dobj | differentiation,regulate |
R1559 | T1951 | T1938 | punct | .,showed |
R1560 | T1952 | T1957 | advmod | Moreover,suggest |
R1561 | T1823 | T1822 | prep | of,differentiation |
R1562 | T1953 | T1957 | punct | ",",suggest |
R1563 | T1954 | T1956 | compound | knockout,studies |
R1564 | T1955 | T1956 | compound | mouse,studies |
R1565 | T1824 | T1829 | det | the,line |
R1566 | T1956 | T1957 | nsubj | studies,suggest |
R1567 | T1957 | T1966 | advcl | suggest,involved |
R1568 | T1825 | T1828 | amod | human,cell |
R1569 | T1958 | T1960 | mark | that,novel |
R1570 | T1959 | T1960 | det | another,novel |
R1571 | T1960 | T1957 | ccomp | novel,suggest |
R1572 | T1961 | T1960 | appos | PKC,novel |
R1573 | T1962 | T1966 | punct | ",",involved |
R1574 | T1963 | T1966 | nsubjpass | PKCε,involved |
R1575 | T1964 | T1966 | auxpass | is,involved |
R1576 | T1826 | T1828 | amod | promyelocytic,cell |
R1577 | T1965 | T1966 | advmod | critically,involved |
R1578 | T1966 | T1966 | ROOT | involved,involved |
R1579 | T1967 | T1966 | prep | in,involved |
R1580 | T1827 | T1828 | compound | leukemia,cell |
R1581 | T1968 | T1970 | amod | early,signaling |
R1582 | T1969 | T1970 | amod | LPS-mediated,signaling |
R1583 | T1970 | T1967 | pobj | signaling,in |
R1584 | T1828 | T1829 | compound | cell,line |
R1585 | T1971 | T1970 | prep | in,signaling |
R1586 | T1972 | T1973 | amod | activated,macrophages |
R1587 | T1973 | T1971 | pobj | macrophages,in |
R1588 | T1829 | T1823 | pobj | line,of |
R1589 | T1974 | T1976 | nmod | [,] |
R1590 | T1975 | T1976 | nummod | 33,] |
R1591 | T1976 | T1970 | appos | ],signaling |
R1592 | T1830 | T1835 | nummod | HL60,] |
R1593 | T1977 | T1966 | punct | .,involved |
R1594 | T1978 | T1981 | advmod | Previously,reported |
R1595 | T1979 | T1981 | punct | ",",reported |
R1596 | T1980 | T1981 | nsubj | we,reported |
R1597 | T1831 | T1835 | prep | to,] |
R1598 | T1981 | T1981 | ROOT | reported,reported |
R1599 | T1982 | T1984 | mark | that,promotes |
R1600 | T1832 | T1831 | pobj | macrophages,to |
R1601 | T1983 | T1984 | nsubj | M-CSF,promotes |
R1602 | T1984 | T1981 | ccomp | promotes,reported |
R1603 | T1833 | T1835 | nmod | [,] |
R1604 | T1985 | T1986 | compound | monocyte,survival |
R1605 | T1834 | T1835 | nummod | 28,] |
R1606 | T1986 | T1984 | dobj | survival,promotes |
R1607 | T1835 | T1829 | appos | ],line |
R1608 | T1987 | T1984 | prep | through,promotes |
R1609 | T1988 | T1989 | det | the,activation |
R1610 | T1989 | T1987 | pobj | activation,through |
R1611 | T1836 | T1821 | punct | .,regulate |
R1612 | T1990 | T1989 | prep | of,activation |
R1613 | T1991 | T1993 | det | the,pathway |
R1614 | T1992 | T1993 | compound | PI3-K/AKT,pathway |
R1615 | T1837 | T1838 | nsubj | PKCα,induces |
R1616 | T1993 | T1990 | pobj | pathway,of |
R1617 | T1994 | T1989 | appos | [,activation |
R1618 | T1838 | T1838 | ROOT | induces,induces |
R1619 | T1995 | T1996 | nummod | 3,] |
R1620 | T1996 | T1994 | appos | ],[ |
R1621 | T1997 | T1981 | punct | .,reported |
R1622 | T1998 | T2005 | prep | In,stimulates |
R1623 | T1999 | T1998 | pobj | addition,In |
R1624 | T2000 | T1999 | prep | to,addition |
R1625 | T1839 | T1838 | dobj | IL-1α,induces |
R1626 | T2001 | T2002 | compound | AKT,activation |
R1627 | T2002 | T2000 | pobj | activation,to |
R1628 | T2003 | T2005 | punct | ",",stimulates |
R1629 | T1840 | T1839 | punct | ",",IL-1α |
R1630 | T2004 | T2005 | nsubj | M-CSF,stimulates |
R1631 | T2005 | T2005 | ROOT | stimulates,stimulates |
R1632 | T2006 | T2005 | dobj | PKC,stimulates |
R1633 | T2007 | T2005 | prep | in,stimulates |
R1634 | T1841 | T1839 | conj | iNOS,IL-1α |
R1635 | T2008 | T2009 | amod | human,monocytes |
R1636 | T2009 | T2007 | pobj | monocytes,in |
R1637 | T2010 | T2009 | cc | and,monocytes |
R1638 | T1842 | T1841 | cc | and,iNOS |
R1639 | T2011 | T2009 | conj | increases,monocytes |
R1640 | T2012 | T2013 | compound | NF-κB,DNA |
R1641 | T2013 | T2017 | det | DNA,] |
R1642 | T2038 | T2043 | prep | In,plays |
R1643 | T2014 | T2017 | amod | binding,] |
R1644 | T2015 | T2017 | nmod | [,] |
R1645 | T2016 | T2017 | nummod | 34,] |
R1646 | T2017 | T2005 | dobj | ],stimulates |
R1647 | T2039 | T2040 | amod | other,cells |
R1648 | T2018 | T2005 | punct | .,stimulates |
R1649 | T2019 | T2035 | advmod | However,is |
R1650 | T2020 | T2035 | punct | ",",is |
R1651 | T2021 | T2026 | mark | whether,is |
R1652 | T2040 | T2038 | pobj | cells,In |
R1653 | T2022 | T2025 | poss | PKC,activation |
R1654 | T2023 | T2022 | cc | and/or,PKC |
R1655 | T2024 | T2022 | conj | NF-κB,PKC |
R1656 | T2041 | T2043 | punct | ",",plays |
R1657 | T2025 | T2026 | nsubj | activation,is |
R1658 | T2026 | T2035 | csubj | is,is |
R1659 | T2027 | T2026 | acomp | critical,is |
R1660 | T2028 | T2027 | prep | in,critical |
R1661 | T2042 | T2043 | nsubj | PKC,plays |
R1662 | T2029 | T2032 | amod | M-CSF-stimulated,survival |
R1663 | T2030 | T2032 | nmod | mononuclear,survival |
R1664 | T2031 | T2032 | compound | phagocyte,survival |
R1665 | T2043 | T2043 | ROOT | plays,plays |
R1666 | T2032 | T2028 | pobj | survival,in |
R1667 | T2033 | T2032 | cc | and/or,survival |
R1668 | T2034 | T2032 | conj | differentiation,survival |
R1669 | T2044 | T2046 | det | an,role |
R1670 | T2035 | T2035 | ROOT | is,is |
R1671 | T2036 | T2035 | acomp | unclear,is |
R1672 | T2037 | T2035 | punct | .,is |
R1673 | T2045 | T2046 | amod | important,role |
R1674 | T2046 | T2043 | dobj | role,plays |
R1675 | T2047 | T2046 | prep | in,role |
R1676 | T2135 | T2132 | conj | siRNA,constructs |
R1677 | T2048 | T2049 | amod | NF-κB,activation |
R1678 | T2136 | T2117 | punct | .,reduced |
R1679 | T2137 | T2137 | ROOT | Conventional,Conventional |
R1680 | T2138 | T2139 | nsubj | PKC,regulated |
R1681 | T2139 | T2139 | ROOT | regulated,regulated |
R1682 | T2049 | T2047 | pobj | activation,in |
R1683 | T2140 | T2142 | amod | NF-κB-regulated,expression |
R1684 | T2141 | T2142 | compound | gene,expression |
R1685 | T2050 | T2049 | cc | and,activation |
R1686 | T2142 | T2139 | dobj | expression,regulated |
R1687 | T2143 | T2142 | cc | and,expression |
R1688 | T2051 | T2052 | compound | cell,survival |
R1689 | T2052 | T2049 | conj | survival,activation |
R1690 | T2144 | T2142 | conj | phosphorylation,expression |
R1691 | T2145 | T2142 | prep | of,expression |
R1692 | T2053 | T2055 | nmod | [,] |
R1693 | T2146 | T2145 | pobj | Ser276,of |
R1694 | T2147 | T2146 | prep | of,Ser276 |
R1695 | T2148 | T2147 | pobj | NF-κB,of |
R1696 | T2054 | T2055 | nummod | 35,] |
R1697 | T2149 | T2148 | nummod | p65,NF-κB |
R1698 | T2150 | T2139 | conj | occurred,regulated |
R1699 | T2055 | T2073 | nsubjpass | ],known |
R1700 | T2151 | T2150 | prep | in,occurred |
R1701 | T2152 | T2154 | det | an,fashion |
R1702 | T2153 | T2154 | amod | M-CSF-dependent,fashion |
R1703 | T2056 | T2060 | punct | ",",mechanisms |
R1704 | T2154 | T2151 | pobj | fashion,in |
R1705 | T2155 | T2154 | acl | correlating,fashion |
R1706 | T2156 | T2155 | prep | with,correlating |
R1707 | T2057 | T2060 | advmod | however,mechanisms |
R1708 | T2157 | T2160 | poss | its,activity |
R1709 | T2158 | T2160 | amod | maximal,activity |
R1710 | T2058 | T2060 | det | the,mechanisms |
R1711 | T2159 | T2160 | amod | transcriptional,activity |
R1712 | T2160 | T2156 | pobj | activity,with |
R1713 | T2161 | T2139 | punct | .,regulated |
R1714 | T2059 | T2060 | amod | specific,mechanisms |
R1715 | T2162 | T2171 | advmod | Furthermore,plays |
R1716 | T2163 | T2171 | punct | ",",plays |
R1717 | T2164 | T2165 | amod | PKCα-regulated,phosphorylation |
R1718 | T2060 | T2073 | nsubjpass | mechanisms,known |
R1719 | T2165 | T2171 | nsubj | phosphorylation,plays |
R1720 | T2166 | T2165 | prep | of,phosphorylation |
R1721 | T2167 | T2166 | pobj | Ser276,of |
R1722 | T2168 | T2167 | prep | of,Ser276 |
R1723 | T2169 | T2168 | pobj | NF-κB,of |
R1724 | T2170 | T2169 | nummod | p65,NF-κB |
R1725 | T2171 | T2171 | ROOT | plays,plays |
R1726 | T2061 | T2060 | prep | of,mechanisms |
R1727 | T2172 | T2174 | det | an,role |
R1728 | T2173 | T2174 | amod | important,role |
R1729 | T2174 | T2171 | dobj | role,plays |
R1730 | T2175 | T2174 | prep | in,role |
R1731 | T2062 | T2063 | det | this,activation |
R1732 | T2176 | T2175 | pcomp | regulating,in |
R1733 | T2177 | T2178 | poss | its,activity |
R1734 | T2178 | T2176 | dobj | activity,regulating |
R1735 | T2063 | T2061 | pobj | activation,of |
R1736 | T2179 | T2176 | prep | in,regulating |
R1737 | T2180 | T2181 | compound | mononuclear,phagocytes |
R1738 | T2181 | T2179 | pobj | phagocytes,in |
R1739 | T2064 | T2063 | cc | and,activation |
R1740 | T2182 | T2181 | cc | and,phagocytes |
R1741 | T2183 | T2185 | amod | murine,fibroblasts |
R1742 | T2184 | T2185 | amod | embryonic,fibroblasts |
R1743 | T2065 | T2067 | det | the,effects |
R1744 | T2185 | T2181 | conj | fibroblasts,phagocytes |
R1745 | T2186 | T2171 | punct | .,plays |
R1746 | T2066 | T2067 | amod | biological,effects |
R1747 | T2067 | T2063 | conj | effects,activation |
R1748 | T2068 | T2067 | prep | on,effects |
R1749 | T2069 | T2070 | amod | cellular,phenotype |
R1750 | T2070 | T2068 | pobj | phenotype,on |
R1751 | T2071 | T2073 | auxpass | are,known |
R1752 | T2072 | T2073 | neg | not,known |
R1753 | T2073 | T2073 | ROOT | known,known |
R1760 | T2074 | T2073 | punct | .,known |
R1761 | T2075 | T2078 | advmod | Therefore,focused |
R1767 | T2076 | T2078 | punct | ",",focused |
R1770 | T2077 | T2078 | nsubj | we,focused |
R1776 | T2078 | T2078 | ROOT | focused,focused |
R1780 | T2079 | T2078 | prep | at,focused |
R1782 | T2080 | T2079 | pcomp | understanding,at |
R1791 | T2081 | T2082 | det | the,role |
R1794 | T2082 | T2080 | dobj | role,understanding |
R1795 | T2083 | T2082 | prep | of,role |
R1798 | T2084 | T2083 | pobj | PKC,of |
R1804 | T2085 | T2082 | prep | in,role |
R1806 | T2086 | T2087 | det | the,regulation |
R1810 | T2087 | T2085 | pobj | regulation,in |
R1815 | T2088 | T2087 | prep | of,regulation |
R1817 | T2089 | T2090 | amod | NF-κB,activation |
R1818 | T2090 | T2088 | pobj | activation,of |
R1824 | T2091 | T2090 | cc | and,activation |
R1826 | T2092 | T2094 | amod | M-CSF-induced,survival |
R1827 | T2093 | T2094 | compound | monocyte,survival |
R1836 | T2094 | T2090 | conj | survival,activation |
R1840 | T2095 | T2078 | punct | .,focused |
R1845 | T2096 | T2098 | advmod | Here,demonstrates |
R1848 | T2097 | T2098 | nsubj | we,demonstrates |
R1853 | T2098 | T2098 | ROOT | demonstrates,demonstrates |
R1859 | T2099 | T2101 | mark | that,upregulated |
R1861 | T2100 | T2101 | nsubj | M-CSF,upregulated |
R1864 | T2101 | T2098 | ccomp | upregulated,demonstrates |
R1865 | T2102 | T2104 | det | the,transcription |
R1868 | T2103 | T2104 | compound | NF-κB,transcription |
R1871 | T2104 | T2101 | dobj | transcription,upregulated |
R1879 | T2105 | T2104 | cc | and,transcription |
R1885 | T2106 | T2107 | compound | cell,survival |
R1889 | T2107 | T2104 | conj | survival,transcription |
R1893 | T2108 | T2104 | prep | in,transcription |
R1894 | T2109 | T2112 | amod | human,macrophages |
R1898 | T2110 | T2109 | cc | and,human |
R1905 | T2111 | T2109 | conj | mouse,human |
R1911 | T2112 | T2108 | pobj | macrophages,in |
R1913 | T2113 | T2098 | punct | .,demonstrates |
R1916 | T2114 | T2115 | det | This,activity |
R1919 | T2115 | T2117 | nsubjpass | activity,reduced |
R1926 | T2116 | T2117 | auxpass | was,reduced |
R1930 | T2117 | T2117 | ROOT | reduced,reduced |
R1933 | T2118 | T2117 | agent | by,reduced |
R1936 | T2119 | T2120 | det | the,conventional |
R1940 | T2120 | T2118 | pobj | conventional,by |
R1944 | T2121 | T2117 | punct | ",",reduced |
R1948 | T2122 | T2117 | cc | but,reduced |
R1951 | T2123 | T2124 | neg | not,novel |
R1954 | T2124 | T2117 | conj | novel,reduced |
R1955 | T2125 | T2124 | punct | ",",novel |
R1956 | T2126 | T2127 | compound | PKC,inhibitors |
R1957 | T2127 | T2124 | appos | inhibitors,novel |
R1960 | T2128 | T2127 | punct | ",",inhibitors |
R1963 | T2129 | T2132 | amod | dominant,constructs |
R1964 | T2130 | T2132 | amod | negative,constructs |
R1966 | T2131 | T2132 | compound | PKCα,constructs |
R1977 | T2132 | T2127 | conj | constructs,inhibitors |
R1978 | T2133 | T2132 | cc | or,constructs |
R1984 | T2134 | T2135 | compound | PKCα,siRNA |
R10607 | T14524 | T14523 | prep | in,important |
test2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T907 | 162-198 | Protein | denotes | Macrophage colony-stimulating factor |
T908 | 200-205 | Protein | denotes | M-CSF |
T909 | 287-292 | Protein | denotes | M-CSF |
T910 | 543-548 | Protein | denotes | M-CSF |
T911 | 866-870 | Protein | denotes | RelA |
T912 | 871-874 | Protein | denotes | p65 |
T913 | 876-879 | Protein | denotes | p50 |
T914 | 881-884 | Protein | denotes | p52 |
T915 | 886-891 | Protein | denotes | c-Rel |
T916 | 896-900 | Protein | denotes | RelB |
T917 | 944-947 | Protein | denotes | p50 |
T918 | 948-951 | Protein | denotes | p65 |
T919 | 1010-1013 | Protein | denotes | p65 |
T920 | 1029-1032 | Protein | denotes | p65 |
T921 | 1093-1100 | Negative_regulation | denotes | lacking |
T922 | 1107-1110 | Protein | denotes | p65 |
T923 | 1217-1220 | Protein | denotes | p65 |
T924 | 1221-1225 | Negative_regulation | denotes | null |
T925 | 1250-1254 | Protein | denotes | TNFα |
T926 | 1293-1307 | Gene_expression | denotes | overexpressing |
T927 | 1318-1321 | Protein | denotes | p65 |
T928 | 1984-1987 | Protein | denotes | p50 |
T929 | 1988-1991 | Protein | denotes | p65 |
T930 | 2033-2037 | Protein | denotes | IκBα |
T931 | 2091-2095 | Protein | denotes | IκBα |
T932 | 2099-2113 | Phosphorylation | denotes | phosphorylated |
T933 | 2134-2142 | Protein_catabolism | denotes | degraded |
T934 | 2144-2153 | Negative_regulation | denotes | releasing |
T935 | 2160-2163 | Protein | denotes | p50 |
T936 | 2164-2167 | Protein | denotes | p65 |
T937 | 2171-2182 | Localization | denotes | translocate |
T938 | 2190-2197 | Entity | denotes | nucleus |
T939 | 2240-2247 | Localization | denotes | release |
T940 | 2253-2257 | Protein | denotes | IκBα |
T941 | 2265-2268 | Protein | denotes | p65 |
T942 | 2281-2312 | Protein_modification | denotes | post-translational modification |
T943 | 2349-2353 | Regulation | denotes | role |
T944 | 2363-2366 | Protein | denotes | p65 |
T945 | 2367-2382 | Phosphorylation | denotes | phosphorylation |
T946 | 2506-2521 | Phosphorylation | denotes | phosphorylation |
T947 | 2531-2534 | Protein | denotes | p65 |
T948 | 2538-2544 | Entity | denotes | Ser276 |
T949 | 2546-2552 | Entity | denotes | Ser529 |
T950 | 2556-2562 | Entity | denotes | Ser536 |
T951 | 2677-2683 | Entity | denotes | Ser276 |
T952 | 2693-2696 | Protein | denotes | p65 |
T953 | 2700-2714 | Phosphorylation | denotes | phosphorylated |
T954 | 2718-2722 | Protein | denotes | MSK1 |
T955 | 2858-2873 | Phosphorylation | denotes | phosphorylation |
T956 | 2877-2883 | Entity | denotes | Ser276 |
T957 | 2888-2894 | Entity | denotes | Ser536 |
T958 | 2903-2912 | Regulation | denotes | regulated |
T959 | 2948-2952 | Protein | denotes | IKKβ |
R616 | T908 | T907 | equivalentTo | M-CSF,Macrophage colony-stimulating factor |
R617 | T912 | T911 | equivalentTo | p65,RelA |
R618 | T922 | T921 | themeOf | p65,lacking |
R619 | T923 | T924 | themeOf | p65,null |
R620 | T927 | T926 | themeOf | p65,overexpressing |
R621 | T931 | T933 | themeOf | IκBα,degraded |
R622 | T931 | T932 | themeOf | IκBα,phosphorylated |
R623 | T935 | T937 | themeOf | p50,translocate |
R624 | T936 | T937 | themeOf | p65,translocate |
R625 | T937 | T934 | themeOf | translocate,releasing |
R626 | T938 | T937 | locationOf | nucleus,translocate |
R627 | T940 | T939 | themeOf | IκBα,release |
R628 | T940 | T942 | themeOf | IκBα,post-translational modification |
R629 | T941 | T939 | themeOf | p65,release |
R630 | T941 | T942 | themeOf | p65,post-translational modification |
R631 | T944 | T945 | themeOf | p65,phosphorylation |
R632 | T945 | T943 | themeOf | phosphorylation,role |
R633 | T948 | T946 | themeOf | Ser276,phosphorylation |
R634 | T948 | T947 | partOf | Ser276,p65 |
R635 | T949 | T947 | partOf | Ser529,p65 |
R636 | T949 | T946 | themeOf | Ser529,phosphorylation |
R637 | T950 | T946 | themeOf | Ser536,phosphorylation |
R638 | T950 | T947 | partOf | Ser536,p65 |
R639 | T951 | T953 | themeOf | Ser276,phosphorylated |
R640 | T951 | T952 | partOf | Ser276,p65 |
R641 | T954 | T953 | causeOf | MSK1,phosphorylated |
R642 | T955 | T958 | themeOf | phosphorylation,regulated |
R643 | T956 | T955 | themeOf | Ser276,phosphorylation |
R644 | T957 | T955 | themeOf | Ser536,phosphorylation |
R645 | T959 | T958 | causeOf | IKKβ,regulated |