PMC:3245220 / 134-1346
Annnotations
bionlp-st-ge-2016-uniprot
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T443 | 0-36 | P09603 | denotes | Macrophage colony-stimulating factor |
| T444 | 11-36 | P04141 | denotes | colony-stimulating factor |
| T445 | 38-43 | P09603 | denotes | M-CSF |
| T446 | 40-43 | P04141 | denotes | CSF |
| T447 | 199-204 | P09603 | denotes | M-CSF |
| T448 | 201-204 | P04141 | denotes | CSF |
| T449 | 359-364 | P09603 | denotes | M-CSF |
| T450 | 361-364 | P04141 | denotes | CSF |
| T451 | 573-577 | P17252 | denotes | PKCα |
| T452 | 635-639 | P17252 | denotes | PKCα |
| T453 | 655-659 | P17252 | denotes | PKCα |
| T454 | 704-709 | P09603 | denotes | M-CSF |
| T455 | 706-709 | P04141 | denotes | CSF |
| T456 | 801-806 | P09603 | denotes | M-CSF |
| T457 | 803-806 | P04141 | denotes | CSF |
| T458 | 891-895 | P17252 | denotes | PKCα |
| T459 | 930-935 | P09603 | denotes | M-CSF |
| T460 | 932-935 | P04141 | denotes | CSF |
| T461 | 1017-1020 | Q04206 | denotes | p65 |
| T462 | 1017-1020 | P21579 | denotes | p65 |
| T463 | 1097-1100 | Q04206 | denotes | p65 |
| T464 | 1097-1100 | P21579 | denotes | p65 |
| T465 | 1145-1150 | P09603 | denotes | M-CSF |
| T466 | 1147-1150 | P04141 | denotes | CSF |
bionlp-st-ge-2016-reference
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T468 | 580-589 | Negative_regulation | denotes | inhibitor |
| T469 | 580-589 | Negative_regulation | denotes | inhibitor |
| T470 | 599-613 | Gene_expression | denotes | overexpression |
| T471 | 737-744 | Negative_regulation | denotes | reduced |
| T472 | 752-767 | Phosphorylation | denotes | phosphorylation |
| T473 | 899-908 | Regulation | denotes | important |
| T474 | 936-943 | Positive_regulation | denotes | induced |
| T475 | 1028-1043 | Phosphorylation | denotes | phosphorylation |
| T478 | 745-751 | Entity | denotes | Ser276 |
| T479 | 1021-1027 | Entity | denotes | Ser276 |
| T480 | 573-577 | Protein | denotes | PKCα |
| T484 | 0-36 | Protein | denotes | Macrophage colony-stimulating factor |
| T485 | 38-43 | Protein | denotes | M-CSF |
| T486 | 199-204 | Protein | denotes | M-CSF |
| T487 | 704-709 | Protein | denotes | M-CSF |
| T488 | 801-806 | Protein | denotes | M-CSF |
| T489 | 930-935 | Protein | denotes | M-CSF |
| T490 | 1145-1150 | Protein | denotes | M-CSF |
| T491 | 578-579 | Protein | denotes | β |
| T492 | 359-364 | Protein | denotes | M-CSF |
| T493 | 1101-1107 | Entity | denotes | Ser276 |
| T494 | 617-639 | Protein | denotes | dominant negative PKCα |
| T495 | 655-665 | Protein | denotes | PKCα siRNA |
| T496 | 776-779 | Protein | denotes | p65 |
| T497 | 891-895 | Protein | denotes | PKCα |
| T498 | 1017-1020 | Protein | denotes | p65 |
| T499 | 1097-1100 | Protein | denotes | p65 |
| R402 | T472 | T471 | themeOf | phosphorylation,reduced |
| R403 | T474 | T473 | themeOf | induced,important |
| R404 | T475 | T474 | themeOf | phosphorylation,induced |
| R407 | T478 | T472 | themeOf | Ser276,phosphorylation |
| R408 | T478 | T496 | partOf | Ser276,p65 |
| R409 | T479 | T475 | themeOf | Ser276,phosphorylation |
| R410 | T479 | T498 | partOf | Ser276,p65 |
| R411 | T480 | T468 | themeOf | PKCα,inhibitor |
| R414 | T485 | T484 | equivalentTo | M-CSF,Macrophage colony-stimulating factor |
| R415 | T491 | T469 | themeOf | β,inhibitor |
| R416 | T493 | T499 | partOf | Ser276,p65 |
| R417 | T494 | T470 | themeOf | dominant negative PKCα,overexpression |
bionlp-st-ge-2016-reference-tees
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T738 | 0-36 | Protein | denotes | Macrophage colony-stimulating factor |
| T739 | 38-43 | Protein | denotes | M-CSF |
| T741 | 152-157 | Protein | denotes | NF-κB |
| T742 | 199-204 | Protein | denotes | M-CSF |
| T743 | 299-304 | Protein | denotes | NF-κB |
| T744 | 321-331 | Positive_regulation | denotes | activation |
| T745 | 359-364 | Protein | denotes | M-CSF |
| T746 | 376-381 | Protein | denotes | NF-κB |
| T747 | 503-527 | Protein | denotes | general protein kinase C |
| T748 | 529-532 | Protein | denotes | PKC |
| T749 | 573-579 | Protein | denotes | PKCα/β |
| T750 | 617-650 | Protein | denotes | dominant negative PKCα constructs |
| T751 | 655-673 | Protein | denotes | PKCα siRNA reduced |
| T752 | 674-679 | Protein | denotes | NF-κB |
| T753 | 704-709 | Protein | denotes | M-CSF |
| T754 | 599-613 | Gene_expression | denotes | overexpression |
| T755 | 599-613 | Gene_expression | denotes | overexpression |
| T756 | 599-613 | Gene_expression | denotes | overexpression |
| T757 | 599-613 | Gene_expression | denotes | overexpression |
| T758 | 692-700 | Positive_regulation | denotes | response |
| T759 | 692-700 | Positive_regulation | denotes | response |
| T760 | 692-700 | Positive_regulation | denotes | response |
| T761 | 692-700 | Positive_regulation | denotes | response |
| T762 | 692-700 | Positive_regulation | denotes | response |
| T763 | 771-779 | Protein | denotes | NF-κBp65 |
| T764 | 801-806 | Protein | denotes | M-CSF |
| T765 | 745-751 | Entity | denotes | Ser276 |
| T766 | 752-767 | Phosphorylation | denotes | phosphorylation |
| T767 | 791-800 | Negative_regulation | denotes | decreased |
| T768 | 737-744 | Negative_regulation | denotes | reduced |
| T769 | 875-879 | Protein | denotes | PKCs |
| T770 | 891-895 | Protein | denotes | PKCα |
| T771 | 930-935 | Protein | denotes | M-CSF |
| T772 | 944-949 | Protein | denotes | NF-κB |
| T773 | 978-983 | Protein | denotes | NF-κB |
| T774 | 1011-1020 | Protein | denotes | NF-κB p65 |
| T775 | 1021-1027 | Protein | denotes | Ser276 |
| T776 | 1028-1043 | Phosphorylation | denotes | phosphorylation |
| T777 | 1028-1043 | Phosphorylation | denotes | phosphorylation |
| T778 | 918-925 | Positive_regulation | denotes | kinases |
| T779 | 918-925 | Positive_regulation | denotes | kinases |
| T780 | 1091-1100 | Protein | denotes | NF-κB p65 |
| T781 | 1101-1107 | Protein | denotes | Ser276 |
| T782 | 1145-1150 | Protein | denotes | M-CSF |
| T783 | 1162-1167 | Protein | denotes | NF-κB |
| T784 | 1168-1178 | Positive_regulation | denotes | activation |
| T785 | 1151-1161 | Positive_regulation | denotes | stimulated |
| T786 | 1168-1178 | Positive_regulation | denotes | activation |
| T740 | 129-150 | Protein | denotes | Nuclear Factor-kappaB |
| R524 | T743 | T744 | themeOf | NF-κB,activation |
| R525 | T747 | T754 | themeOf | general protein kinase C,overexpression |
| R526 | T748 | T755 | themeOf | PKC,overexpression |
| R527 | T750 | T756 | themeOf | dominant negative PKCα constructs,overexpression |
| R528 | T751 | T757 | themeOf | PKCα siRNA reduced,overexpression |
| R529 | T751 | T758 | causeOf | PKCα siRNA reduced,response |
| R530 | T751 | T759 | causeOf | PKCα siRNA reduced,response |
| R531 | T751 | T760 | causeOf | PKCα siRNA reduced,response |
| R532 | T751 | T761 | causeOf | PKCα siRNA reduced,response |
| R533 | T751 | T762 | causeOf | PKCα siRNA reduced,response |
| R534 | T753 | T758 | themeOf | M-CSF,response |
| R535 | T754 | T759 | themeOf | overexpression,response |
| R536 | T755 | T760 | themeOf | overexpression,response |
| R537 | T756 | T761 | themeOf | overexpression,response |
| R538 | T757 | T762 | themeOf | overexpression,response |
| R539 | T763 | T766 | themeOf | NF-κBp65,phosphorylation |
| R540 | T763 | T765 | partOf | NF-κBp65,Ser276 |
| R541 | T765 | T766 | Site | Ser276,phosphorylation |
| R542 | T766 | T767 | themeOf | phosphorylation,decreased |
| R543 | T766 | T768 | themeOf | phosphorylation,reduced |
| R544 | T770 | T778 | causeOf | PKCα,kinases |
| R545 | T770 | T779 | causeOf | PKCα,kinases |
| R546 | T774 | T776 | themeOf | NF-κB p65,phosphorylation |
| R547 | T775 | T777 | themeOf | Ser276,phosphorylation |
| R548 | T776 | T778 | themeOf | phosphorylation,kinases |
| R549 | T777 | T779 | themeOf | phosphorylation,kinases |
| R550 | T782 | T785 | causeOf | M-CSF,stimulated |
| R551 | T783 | T784 | themeOf | NF-κB,activation |
| R552 | T784 | T785 | themeOf | activation,stimulated |
| R553 | T785 | T786 | themeOf | stimulated,activation |
events-check-again
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T701 | 0-36 | Protein | denotes | Macrophage colony-stimulating factor |
| T702 | 38-43 | Protein | denotes | M-CSF |
| T703 | 199-204 | Protein | denotes | M-CSF |
| T704 | 359-364 | Protein | denotes | M-CSF |
| T705 | 573-577 | Protein | denotes | PKCα |
| T706 | 578-579 | Protein | denotes | β |
| T707 | 580-589 | Negative_regulation | denotes | inhibitor |
| T708 | 580-589 | Negative_regulation | denotes | inhibitor |
| T709 | 599-613 | Gene_expression | denotes | overexpression |
| T710 | 617-639 | Protein | denotes | dominant negative PKCα |
| T711 | 655-665 | Protein | denotes | PKCα siRNA |
| T712 | 704-709 | Protein | denotes | M-CSF |
| T713 | 737-744 | Negative_regulation | denotes | reduced |
| T714 | 745-751 | Entity | denotes | Ser276 |
| T715 | 752-767 | Phosphorylation | denotes | phosphorylation |
| T716 | 776-779 | Protein | denotes | p65 |
| T717 | 801-806 | Protein | denotes | M-CSF |
| T718 | 891-895 | Protein | denotes | PKCα |
| T719 | 899-908 | Regulation | denotes | important |
| T720 | 930-935 | Protein | denotes | M-CSF |
| T721 | 936-943 | Positive_regulation | denotes | induced |
| T722 | 1017-1020 | Protein | denotes | p65 |
| T723 | 1021-1027 | Entity | denotes | Ser276 |
| T724 | 1028-1043 | Phosphorylation | denotes | phosphorylation |
| T725 | 1097-1100 | Protein | denotes | p65 |
| T726 | 1101-1107 | Entity | denotes | Ser276 |
| T727 | 1145-1150 | Protein | denotes | M-CSF |
| R500 | T702 | T701 | equivalentTo | M-CSF,Macrophage colony-stimulating factor |
| R501 | T705 | T707 | themeOf | PKCα,inhibitor |
| R502 | T706 | T708 | themeOf | β,inhibitor |
| R503 | T710 | T709 | themeOf | dominant negative PKCα,overexpression |
| R504 | T714 | T715 | themeOf | Ser276,phosphorylation |
| R505 | T714 | T716 | partOf | Ser276,p65 |
| R506 | T715 | T713 | themeOf | phosphorylation,reduced |
| R507 | T721 | T719 | themeOf | induced,important |
| R508 | T723 | T724 | themeOf | Ser276,phosphorylation |
| R509 | T723 | T722 | partOf | Ser276,p65 |
| R510 | T724 | T721 | themeOf | phosphorylation,induced |
| R511 | T726 | T725 | partOf | Ser276,p65 |
GO-CC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T533 | 478-482 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
GO-MF
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T528 | 529-532 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
| T529 | 573-577 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCα |
| T530 | 635-639 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCα |
| T531 | 655-659 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCα |
| T532 | 891-895 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCα |
GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T509 | 752-767 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
| T510 | 1028-1043 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
| T511 | 108-121 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T512 | 305-320 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcriptional |
| T513 | 382-397 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcriptional |
| T514 | 950-965 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcriptional |
| T515 | 529-532 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKC |
| T516 | 573-577 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCα |
| T517 | 635-639 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCα |
| T518 | 655-659 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCα |
| T519 | 891-895 | http://purl.obolibrary.org/obo/GO_0004697 | denotes | PKCα |
| T520 | 680-700 | http://purl.obolibrary.org/obo/GO_0014823 | denotes | activity in response |
| T521 | 692-709 | http://purl.obolibrary.org/obo/GO_1903969 | denotes | response to M-CSF |
| T522 | 692-709 | http://purl.obolibrary.org/obo/GO_0036005 | denotes | response to M-CSF |
| T523 | 692-709 | http://purl.obolibrary.org/obo/GO_1903970 | denotes | response to M-CSF |
| T524 | 692-709 | http://purl.obolibrary.org/obo/GO_1903971 | denotes | response to M-CSF |
| T525 | 966-983 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | activation, NF-κB |
| T526 | 1162-1178 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
| T527 | 994-1009 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
| T18591 | 108-320 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription factor Nuclear Factor-kappaB (NF-κB) is a key regulator of genes involved in M-CSF-induced mononuclear phagocyte survival and this study focused at identifying the mechanism of NF-κB transcriptional |
pmc-enju-pas
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T268 | 0-10 | NN | denotes | Macrophage |
| T269 | 11-29 | JJ | denotes | colony-stimulating |
| T270 | 30-36 | NN | denotes | factor |
| T271 | 37-38 | -LRB- | denotes | ( |
| T272 | 38-43 | NN | denotes | M-CSF |
| T273 | 43-44 | -RRB- | denotes | ) |
| T274 | 45-53 | VB | denotes | promotes |
| T275 | 54-65 | JJ | denotes | mononuclear |
| T276 | 66-75 | NN | denotes | phagocyte |
| T277 | 76-84 | NN | denotes | survival |
| T278 | 85-88 | CC | denotes | and |
| T279 | 89-102 | NN | denotes | proliferation |
| T280 | 104-107 | DT | denotes | The |
| T281 | 108-121 | NN | denotes | transcription |
| T282 | 122-128 | NN | denotes | factor |
| T283 | 129-136 | JJ | denotes | Nuclear |
| T284 | 137-150 | NN | denotes | Factor-kappaB |
| T285 | 151-152 | -LRB- | denotes | ( |
| T286 | 152-157 | NN | denotes | NF-κB |
| T287 | 157-158 | -RRB- | denotes | ) |
| T288 | 159-161 | VB | denotes | is |
| T289 | 162-163 | DT | denotes | a |
| T290 | 164-167 | JJ | denotes | key |
| T291 | 168-177 | NN | denotes | regulator |
| T292 | 178-180 | IN | denotes | of |
| T293 | 181-186 | NN | denotes | genes |
| T294 | 187-195 | VB | denotes | involved |
| T295 | 196-198 | IN | denotes | in |
| T296 | 199-212 | JJ | denotes | M-CSF-induced |
| T297 | 213-224 | JJ | denotes | mononuclear |
| T298 | 225-234 | NN | denotes | phagocyte |
| T299 | 235-243 | NN | denotes | survival |
| T300 | 244-247 | CC | denotes | and |
| T301 | 248-252 | DT | denotes | this |
| T302 | 253-258 | NN | denotes | study |
| T303 | 259-266 | VB | denotes | focused |
| T304 | 267-269 | IN | denotes | at |
| T305 | 270-281 | VB | denotes | identifying |
| T306 | 282-285 | DT | denotes | the |
| T307 | 286-295 | NN | denotes | mechanism |
| T308 | 296-298 | IN | denotes | of |
| T309 | 299-304 | NN | denotes | NF-κB |
| T310 | 305-320 | JJ | denotes | transcriptional |
| T311 | 321-331 | NN | denotes | activation |
| T312 | 333-337 | RB | denotes | Here |
| T313 | 337-338 | -COMMA- | denotes | , |
| T314 | 339-341 | PRP | denotes | we |
| T315 | 342-353 | VB | denotes | demonstrate |
| T316 | 354-358 | IN | denotes | that |
| T317 | 359-364 | NN | denotes | M-CSF |
| T318 | 365-375 | VB | denotes | stimulated |
| T319 | 376-381 | NN | denotes | NF-κB |
| T320 | 382-397 | JJ | denotes | transcriptional |
| T321 | 398-406 | NN | denotes | activity |
| T322 | 407-409 | IN | denotes | in |
| T323 | 410-415 | JJ | denotes | human |
| T324 | 416-432 | JJ | denotes | monocyte-derived |
| T325 | 433-444 | NN | denotes | macrophages |
| T326 | 445-446 | -LRB- | denotes | ( |
| T327 | 446-450 | NN | denotes | MDMs |
| T328 | 450-451 | -RRB- | denotes | ) |
| T329 | 452-455 | CC | denotes | and |
| T330 | 456-459 | DT | denotes | the |
| T331 | 460-466 | JJ | denotes | murine |
| T332 | 467-477 | NN | denotes | macrophage |
| T333 | 478-482 | NN | denotes | cell |
| T334 | 483-487 | NN | denotes | line |
| T335 | 488-491 | NN | denotes | RAW |
| T336 | 492-497 | CD | denotes | 264.7 |
| T337 | 499-502 | DT | denotes | The |
| T338 | 503-510 | JJ | denotes | general |
| T339 | 511-518 | NN | denotes | protein |
| T340 | 519-525 | NN | denotes | kinase |
| T341 | 526-527 | NN | denotes | C |
| T342 | 528-529 | -LRB- | denotes | ( |
| T343 | 529-532 | NN | denotes | PKC |
| T344 | 532-533 | -RRB- | denotes | ) |
| T345 | 534-543 | NN | denotes | inhibitor |
| T346 | 544-554 | NN | denotes | Ro-31-8220 |
| T347 | 554-555 | -COMMA- | denotes | , |
| T348 | 556-559 | DT | denotes | the |
| T349 | 560-572 | JJ | denotes | conventional |
| T350 | 573-579 | NN | denotes | PKCα/β |
| T351 | 580-589 | NN | denotes | inhibitor |
| T352 | 590-597 | NN | denotes | Gö-6976 |
| T353 | 597-598 | -COMMA- | denotes | , |
| T354 | 599-613 | NN | denotes | overexpression |
| T355 | 614-616 | IN | denotes | of |
| T356 | 617-625 | JJ | denotes | dominant |
| T357 | 626-634 | JJ | denotes | negative |
| T358 | 635-639 | NN | denotes | PKCα |
| T359 | 640-650 | NN | denotes | constructs |
| T360 | 651-654 | CC | denotes | and |
| T361 | 655-659 | NN | denotes | PKCα |
| T362 | 660-665 | NN | denotes | siRNA |
| T363 | 666-673 | VB | denotes | reduced |
| T364 | 674-679 | NN | denotes | NF-κB |
| T365 | 680-688 | NN | denotes | activity |
| T366 | 689-691 | IN | denotes | in |
| T367 | 692-700 | NN | denotes | response |
| T368 | 701-703 | TO | denotes | to |
| T369 | 704-709 | NN | denotes | M-CSF |
| T370 | 711-724 | RB | denotes | Interestingly |
| T371 | 724-725 | -COMMA- | denotes | , |
| T372 | 726-736 | NN | denotes | Ro-31-8220 |
| T373 | 737-744 | VB | denotes | reduced |
| T374 | 745-751 | NN | denotes | Ser276 |
| T375 | 752-767 | NN | denotes | phosphorylation |
| T376 | 768-770 | IN | denotes | of |
| T377 | 771-779 | NN | denotes | NF-κBp65 |
| T378 | 780-787 | VB | denotes | leading |
| T379 | 788-790 | TO | denotes | to |
| T380 | 791-800 | VB | denotes | decreased |
| T381 | 801-814 | JJ | denotes | M-CSF-induced |
| T382 | 815-823 | NN | denotes | monocyte |
| T383 | 824-832 | NN | denotes | survival |
| T384 | 834-836 | IN | denotes | In |
| T385 | 837-841 | DT | denotes | this |
| T386 | 842-848 | NN | denotes | report |
| T387 | 848-849 | -COMMA- | denotes | , |
| T388 | 850-852 | PRP | denotes | we |
| T389 | 853-861 | VB | denotes | identify |
| T390 | 862-874 | JJ | denotes | conventional |
| T391 | 875-879 | NN | denotes | PKCs |
| T392 | 879-880 | -COMMA- | denotes | , |
| T393 | 881-890 | VB | denotes | including |
| T394 | 891-895 | NN | denotes | PKCα |
| T395 | 896-898 | IN | denotes | as |
| T396 | 899-908 | JJ | denotes | important |
| T397 | 909-917 | JJ | denotes | upstream |
| T398 | 918-925 | NN | denotes | kinases |
| T399 | 926-929 | IN | denotes | for |
| T400 | 930-943 | JJ | denotes | M-CSF-induced |
| T401 | 944-949 | NN | denotes | NF-κB |
| T402 | 950-965 | JJ | denotes | transcriptional |
| T403 | 966-976 | NN | denotes | activation |
| T404 | 976-977 | -COMMA- | denotes | , |
| T405 | 978-993 | JJ | denotes | NF-κB-regulated |
| T406 | 994-998 | NN | denotes | gene |
| T407 | 999-1009 | NN | denotes | expression |
| T408 | 1009-1010 | -COMMA- | denotes | , |
| T409 | 1011-1016 | NN | denotes | NF-κB |
| T410 | 1017-1020 | NN | denotes | p65 |
| T411 | 1021-1027 | NN | denotes | Ser276 |
| T412 | 1028-1043 | NN | denotes | phosphorylation |
| T413 | 1043-1044 | -COMMA- | denotes | , |
| T414 | 1045-1048 | CC | denotes | and |
| T415 | 1049-1059 | NN | denotes | macrophage |
| T416 | 1060-1068 | NN | denotes | survival |
| T417 | 1070-1076 | RB | denotes | Lastly |
| T418 | 1076-1077 | -COMMA- | denotes | , |
| T419 | 1078-1080 | PRP | denotes | we |
| T420 | 1081-1085 | VB | denotes | find |
| T421 | 1086-1090 | IN | denotes | that |
| T422 | 1091-1096 | NN | denotes | NF-κB |
| T423 | 1097-1100 | NN | denotes | p65 |
| T424 | 1101-1107 | NN | denotes | Ser276 |
| T425 | 1108-1113 | VB | denotes | plays |
| T426 | 1114-1116 | DT | denotes | an |
| T427 | 1117-1126 | JJ | denotes | important |
| T428 | 1127-1131 | NN | denotes | role |
| T429 | 1132-1134 | IN | denotes | in |
| T430 | 1135-1140 | JJ | denotes | basal |
| T431 | 1141-1144 | CC | denotes | and |
| T432 | 1145-1161 | JJ | denotes | M-CSF-stimulated |
| T433 | 1162-1167 | NN | denotes | NF-κB |
| T434 | 1168-1178 | NN | denotes | activation |
| T435 | 1179-1181 | IN | denotes | in |
| T436 | 1182-1187 | JJ | denotes | human |
| T437 | 1188-1199 | JJ | denotes | mononuclear |
| T438 | 1200-1210 | NN | denotes | phagocytes |
| T15741 | 108-320 | JJ | denotes | transcription factor Nuclear Factor-kappaB (NF-κB) is a key regulator of genes involved in M-CSF-induced mononuclear phagocyte survival and this study focused at identifying the mechanism of NF-κB transcriptional |
| T15742 | 321-406 | NN | denotes | activation. Here, we demonstrate that M-CSF stimulated NF-κB transcriptional activity |
| R236 | T270 | T268 | arg1Of | factor,Macrophage |
| R237 | T270 | T269 | arg1Of | factor,colony-stimulating |
| R238 | T270 | T271 | arg1Of | factor,( |
| R239 | T270 | T274 | arg1Of | factor,promotes |
| R240 | T272 | T271 | arg2Of | M-CSF,( |
| R241 | T273 | T271 | arg3Of | ),( |
| R242 | T277 | T278 | arg1Of | survival,and |
| R243 | T278 | T274 | arg2Of | and,promotes |
| R244 | T278 | T275 | arg1Of | and,mononuclear |
| R245 | T278 | T276 | arg1Of | and,phagocyte |
| R246 | T279 | T278 | arg2Of | proliferation,and |
| R247 | T284 | T280 | arg1Of | Factor-kappaB,The |
| R248 | T284 | T281 | arg1Of | Factor-kappaB,transcription |
| R249 | T284 | T282 | arg1Of | Factor-kappaB,factor |
| R250 | T284 | T283 | arg1Of | Factor-kappaB,Nuclear |
| R251 | T284 | T285 | arg1Of | Factor-kappaB,( |
| R252 | T284 | T288 | arg1Of | Factor-kappaB,is |
| R253 | T286 | T285 | arg2Of | NF-κB,( |
| R254 | T287 | T285 | arg3Of | ),( |
| R255 | T288 | T300 | arg1Of | is,and |
| R256 | T291 | T288 | arg2Of | regulator,is |
| R257 | T291 | T289 | arg1Of | regulator,a |
| R258 | T291 | T290 | arg1Of | regulator,key |
| R259 | T291 | T292 | arg1Of | regulator,of |
| R260 | T293 | T292 | arg2Of | genes,of |
| R261 | T293 | T294 | arg2Of | genes,involved |
| R262 | T294 | T295 | arg1Of | involved,in |
| R263 | T299 | T295 | arg2Of | survival,in |
| R264 | T299 | T296 | arg1Of | survival,M-CSF-induced |
| R265 | T299 | T297 | arg1Of | survival,mononuclear |
| R266 | T299 | T298 | arg1Of | survival,phagocyte |
| R267 | T302 | T301 | arg1Of | study,this |
| R268 | T302 | T303 | arg1Of | study,focused |
| R269 | T303 | T300 | arg2Of | focused,and |
| R270 | T303 | T304 | arg1Of | focused,at |
| R271 | T305 | T304 | arg2Of | identifying,at |
| R272 | T307 | T305 | arg2Of | mechanism,identifying |
| R273 | T307 | T306 | arg1Of | mechanism,the |
| R274 | T307 | T308 | arg1Of | mechanism,of |
| R275 | T311 | T308 | arg2Of | activation,of |
| R276 | T311 | T309 | arg1Of | activation,NF-κB |
| R277 | T311 | T310 | arg1Of | activation,transcriptional |
| R278 | T314 | T315 | arg1Of | we,demonstrate |
| R279 | T315 | T312 | arg1Of | demonstrate,Here |
| R280 | T315 | T313 | arg1Of | demonstrate,"," |
| R281 | T317 | T318 | arg1Of | M-CSF,stimulated |
| R282 | T318 | T315 | arg2Of | stimulated,demonstrate |
| R283 | T318 | T316 | arg1Of | stimulated,that |
| R284 | T321 | T319 | arg1Of | activity,NF-κB |
| R285 | T321 | T320 | arg1Of | activity,transcriptional |
| R286 | T321 | T322 | arg1Of | activity,in |
| R287 | T321 | T329 | arg1Of | activity,and |
| R288 | T325 | T322 | arg2Of | macrophages,in |
| R289 | T325 | T323 | arg1Of | macrophages,human |
| R290 | T325 | T324 | arg1Of | macrophages,monocyte-derived |
| R291 | T325 | T326 | arg1Of | macrophages,( |
| R292 | T327 | T326 | arg2Of | MDMs,( |
| R293 | T328 | T326 | arg3Of | ),( |
| R294 | T329 | T318 | arg2Of | and,stimulated |
| R295 | T335 | T329 | arg2Of | RAW,and |
| R296 | T335 | T330 | arg1Of | RAW,the |
| R297 | T335 | T331 | arg1Of | RAW,murine |
| R298 | T335 | T332 | arg1Of | RAW,macrophage |
| R299 | T335 | T333 | arg1Of | RAW,cell |
| R300 | T335 | T334 | arg1Of | RAW,line |
| R301 | T335 | T336 | arg1Of | RAW,264.7 |
| R302 | T341 | T338 | arg1Of | C,general |
| R303 | T341 | T339 | arg1Of | C,protein |
| R304 | T341 | T340 | arg1Of | C,kinase |
| R305 | T341 | T342 | arg1Of | C,( |
| R306 | T343 | T342 | arg2Of | PKC,( |
| R307 | T344 | T342 | arg3Of | ),( |
| R308 | T346 | T337 | arg1Of | Ro-31-8220,The |
| R309 | T346 | T341 | arg1Of | Ro-31-8220,C |
| R310 | T346 | T345 | arg1Of | Ro-31-8220,inhibitor |
| R311 | T346 | T347 | arg1Of | Ro-31-8220,"," |
| R312 | T346 | T353 | arg1Of | Ro-31-8220,"," |
| R313 | T352 | T347 | arg2Of | Gö-6976,"," |
| R314 | T352 | T348 | arg1Of | Gö-6976,the |
| R315 | T352 | T349 | arg1Of | Gö-6976,conventional |
| R316 | T352 | T350 | arg1Of | Gö-6976,PKCα/β |
| R317 | T352 | T351 | arg1Of | Gö-6976,inhibitor |
| R318 | T353 | T360 | arg1Of | ",",and |
| R319 | T354 | T353 | arg2Of | overexpression,"," |
| R320 | T354 | T355 | arg1Of | overexpression,of |
| R321 | T359 | T355 | arg2Of | constructs,of |
| R322 | T359 | T356 | arg1Of | constructs,dominant |
| R323 | T359 | T357 | arg1Of | constructs,negative |
| R324 | T359 | T358 | arg1Of | constructs,PKCα |
| R325 | T360 | T363 | arg1Of | and,reduced |
| R326 | T362 | T360 | arg2Of | siRNA,and |
| R327 | T362 | T361 | arg1Of | siRNA,PKCα |
| R328 | T363 | T366 | arg1Of | reduced,in |
| R329 | T365 | T363 | arg2Of | activity,reduced |
| R330 | T365 | T364 | arg1Of | activity,NF-κB |
| R331 | T367 | T366 | arg2Of | response,in |
| R332 | T367 | T368 | arg1Of | response,to |
| R333 | T369 | T368 | arg2Of | M-CSF,to |
| R334 | T372 | T373 | arg1Of | Ro-31-8220,reduced |
| R335 | T373 | T370 | arg1Of | reduced,Interestingly |
| R336 | T373 | T371 | arg1Of | reduced,"," |
| R337 | T375 | T373 | arg2Of | phosphorylation,reduced |
| R338 | T375 | T374 | arg1Of | phosphorylation,Ser276 |
| R339 | T375 | T376 | arg1Of | phosphorylation,of |
| R340 | T375 | T378 | arg1Of | phosphorylation,leading |
| R341 | T377 | T376 | arg2Of | NF-κBp65,of |
| R342 | T378 | T379 | arg1Of | leading,to |
| R343 | T383 | T379 | arg2Of | survival,to |
| R344 | T383 | T380 | arg2Of | survival,decreased |
| R345 | T383 | T381 | arg1Of | survival,M-CSF-induced |
| R346 | T383 | T382 | arg1Of | survival,monocyte |
| R347 | T386 | T384 | arg2Of | report,In |
| R348 | T386 | T385 | arg1Of | report,this |
| R349 | T388 | T389 | arg1Of | we,identify |
| R350 | T389 | T384 | arg1Of | identify,In |
| R351 | T389 | T387 | arg1Of | identify,"," |
| R352 | T391 | T389 | arg2Of | PKCs,identify |
| R353 | T391 | T390 | arg1Of | PKCs,conventional |
| R354 | T391 | T392 | arg1Of | PKCs,"," |
| R355 | T391 | T393 | arg1Of | PKCs,including |
| R356 | T394 | T393 | arg2Of | PKCα,including |
| R357 | T394 | T395 | arg1Of | PKCα,as |
| R358 | T398 | T396 | arg1Of | kinases,important |
| R359 | T398 | T397 | arg1Of | kinases,upstream |
| R360 | T398 | T399 | arg1Of | kinases,for |
| R361 | T398 | T414 | arg1Of | kinases,and |
| R362 | T403 | T400 | arg1Of | activation,M-CSF-induced |
| R363 | T403 | T401 | arg1Of | activation,NF-κB |
| R364 | T403 | T402 | arg1Of | activation,transcriptional |
| R365 | T403 | T404 | arg1Of | activation,"," |
| R366 | T404 | T408 | arg1Of | ",","," |
| R367 | T407 | T404 | arg2Of | expression,"," |
| R368 | T407 | T405 | arg1Of | expression,NF-κB-regulated |
| R369 | T407 | T406 | arg1Of | expression,gene |
| R370 | T408 | T399 | arg2Of | ",",for |
| R371 | T412 | T408 | arg2Of | phosphorylation,"," |
| R372 | T412 | T409 | arg1Of | phosphorylation,NF-κB |
| R373 | T412 | T410 | arg1Of | phosphorylation,p65 |
| R374 | T412 | T411 | arg1Of | phosphorylation,Ser276 |
| R375 | T414 | T395 | arg2Of | and,as |
| R376 | T414 | T413 | arg1Of | and,"," |
| R377 | T416 | T414 | arg2Of | survival,and |
| R378 | T416 | T415 | arg1Of | survival,macrophage |
| R379 | T419 | T420 | arg1Of | we,find |
| R380 | T420 | T417 | arg1Of | find,Lastly |
| R381 | T420 | T418 | arg1Of | find,"," |
| R382 | T424 | T422 | arg1Of | Ser276,NF-κB |
| R383 | T424 | T423 | arg1Of | Ser276,p65 |
| R384 | T424 | T425 | arg1Of | Ser276,plays |
| R385 | T425 | T420 | arg2Of | plays,find |
| R386 | T425 | T421 | arg1Of | plays,that |
| R387 | T425 | T429 | arg1Of | plays,in |
| R388 | T428 | T425 | arg2Of | role,plays |
| R389 | T428 | T426 | arg1Of | role,an |
| R390 | T428 | T427 | arg1Of | role,important |
| R391 | T430 | T431 | arg1Of | basal,and |
| R392 | T432 | T431 | arg2Of | M-CSF-stimulated,and |
| R393 | T434 | T429 | arg2Of | activation,in |
| R394 | T434 | T430 | arg1Of | activation,basal |
| R395 | T434 | T432 | arg1Of | activation,M-CSF-stimulated |
| R396 | T434 | T433 | arg1Of | activation,NF-κB |
| R397 | T434 | T435 | arg1Of | activation,in |
| R398 | T438 | T435 | arg2Of | phagocytes,in |
| R399 | T438 | T436 | arg1Of | phagocytes,human |
| R400 | T438 | T437 | arg1Of | phagocytes,mononuclear |
| R11824 | T15742 | T15741 | arg1Of | "activation. Here, we demonstrate that M-CSF stimulated NF-κB transcriptional activity",transcription factor Nuclear Factor-kappaB (NF-κB) is a key regulator of genes involved in M-CSF-induced mononuclear phagocyte survival and this study focused at identifying the mechanism of NF-κB transcriptional |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T51 | 0-103 | Sentence | denotes | Macrophage colony-stimulating factor (M-CSF) promotes mononuclear phagocyte survival and proliferation. |
| T52 | 104-332 | Sentence | denotes | The transcription factor Nuclear Factor-kappaB (NF-κB) is a key regulator of genes involved in M-CSF-induced mononuclear phagocyte survival and this study focused at identifying the mechanism of NF-κB transcriptional activation. |
| T53 | 333-498 | Sentence | denotes | Here, we demonstrate that M-CSF stimulated NF-κB transcriptional activity in human monocyte-derived macrophages (MDMs) and the murine macrophage cell line RAW 264.7. |
| T54 | 499-710 | Sentence | denotes | The general protein kinase C (PKC) inhibitor Ro-31-8220, the conventional PKCα/β inhibitor Gö-6976, overexpression of dominant negative PKCα constructs and PKCα siRNA reduced NF-κB activity in response to M-CSF. |
| T55 | 711-833 | Sentence | denotes | Interestingly, Ro-31-8220 reduced Ser276 phosphorylation of NF-κBp65 leading to decreased M-CSF-induced monocyte survival. |
| T56 | 834-1069 | Sentence | denotes | In this report, we identify conventional PKCs, including PKCα as important upstream kinases for M-CSF-induced NF-κB transcriptional activation, NF-κB-regulated gene expression, NF-κB p65 Ser276 phosphorylation, and macrophage survival. |
| T57 | 1070-1211 | Sentence | denotes | Lastly, we find that NF-κB p65 Ser276 plays an important role in basal and M-CSF-stimulated NF-κB activation in human mononuclear phagocytes. |
| T3 | 0-103 | Sentence | denotes | Macrophage colony-stimulating factor (M-CSF) promotes mononuclear phagocyte survival and proliferation. |
| T4 | 104-332 | Sentence | denotes | The transcription factor Nuclear Factor-kappaB (NF-κB) is a key regulator of genes involved in M-CSF-induced mononuclear phagocyte survival and this study focused at identifying the mechanism of NF-κB transcriptional activation. |
| T5 | 333-498 | Sentence | denotes | Here, we demonstrate that M-CSF stimulated NF-κB transcriptional activity in human monocyte-derived macrophages (MDMs) and the murine macrophage cell line RAW 264.7. |
| T6 | 499-710 | Sentence | denotes | The general protein kinase C (PKC) inhibitor Ro-31-8220, the conventional PKCα/β inhibitor Gö-6976, overexpression of dominant negative PKCα constructs and PKCα siRNA reduced NF-κB activity in response to M-CSF. |
| T7 | 711-833 | Sentence | denotes | Interestingly, Ro-31-8220 reduced Ser276 phosphorylation of NF-κBp65 leading to decreased M-CSF-induced monocyte survival. |
| T8 | 834-1069 | Sentence | denotes | In this report, we identify conventional PKCs, including PKCα as important upstream kinases for M-CSF-induced NF-κB transcriptional activation, NF-κB-regulated gene expression, NF-κB p65 Ser276 phosphorylation, and macrophage survival. |
| T9 | 1070-1211 | Sentence | denotes | Lastly, we find that NF-κB p65 Ser276 plays an important role in basal and M-CSF-stimulated NF-κB activation in human mononuclear phagocytes. |
bionlp-st-ge-2016-spacy-parsed
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T73 | 0-10 | NNP | denotes | Macrophage |
| T74 | 11-29 | JJ | denotes | colony-stimulating |
| T75 | 30-36 | NN | denotes | factor |
| T76 | 37-38 | -LRB- | denotes | ( |
| T77 | 38-43 | NNP | denotes | M-CSF |
| T78 | 43-44 | -RRB- | denotes | ) |
| T79 | 45-53 | VBZ | denotes | promotes |
| T80 | 54-65 | JJ | denotes | mononuclear |
| T81 | 66-75 | JJ | denotes | phagocyte |
| T82 | 76-84 | NN | denotes | survival |
| T83 | 85-88 | CC | denotes | and |
| T84 | 89-102 | NN | denotes | proliferation |
| T85 | 102-103 | . | denotes | . |
| T86 | 104-107 | DT | denotes | The |
| T87 | 108-121 | NN | denotes | transcription |
| T88 | 122-128 | NN | denotes | factor |
| T89 | 129-136 | NNP | denotes | Nuclear |
| T90 | 137-150 | NNP | denotes | Factor-kappaB |
| T91 | 151-152 | -LRB- | denotes | ( |
| T92 | 152-157 | NNP | denotes | NF-κB |
| T93 | 157-158 | -RRB- | denotes | ) |
| T94 | 159-161 | VBZ | denotes | is |
| T95 | 162-163 | DT | denotes | a |
| T96 | 164-167 | JJ | denotes | key |
| T97 | 168-177 | NN | denotes | regulator |
| T98 | 178-180 | IN | denotes | of |
| T99 | 181-186 | NNS | denotes | genes |
| T100 | 187-195 | VBN | denotes | involved |
| T101 | 196-198 | IN | denotes | in |
| T102 | 199-212 | JJ | denotes | M-CSF-induced |
| T103 | 213-224 | NN | denotes | mononuclear |
| T104 | 225-234 | NN | denotes | phagocyte |
| T105 | 235-243 | NN | denotes | survival |
| T106 | 244-247 | CC | denotes | and |
| T107 | 248-252 | DT | denotes | this |
| T108 | 253-258 | NN | denotes | study |
| T109 | 259-266 | VBD | denotes | focused |
| T110 | 267-269 | IN | denotes | at |
| T111 | 270-281 | VBG | denotes | identifying |
| T112 | 282-285 | DT | denotes | the |
| T113 | 286-295 | NN | denotes | mechanism |
| T114 | 296-298 | IN | denotes | of |
| T115 | 299-304 | JJ | denotes | NF-κB |
| T116 | 305-320 | JJ | denotes | transcriptional |
| T117 | 321-331 | NN | denotes | activation |
| T118 | 331-332 | . | denotes | . |
| T119 | 333-337 | RB | denotes | Here |
| T120 | 337-338 | , | denotes | , |
| T121 | 339-341 | PRP | denotes | we |
| T122 | 342-353 | VBP | denotes | demonstrate |
| T123 | 354-358 | IN | denotes | that |
| T124 | 359-364 | NNP | denotes | M-CSF |
| T125 | 365-375 | VBD | denotes | stimulated |
| T126 | 376-381 | NNP | denotes | NF-κB |
| T127 | 382-397 | JJ | denotes | transcriptional |
| T128 | 398-406 | NN | denotes | activity |
| T129 | 407-409 | IN | denotes | in |
| T130 | 410-415 | JJ | denotes | human |
| T131 | 416-432 | JJ | denotes | monocyte-derived |
| T132 | 433-444 | NNS | denotes | macrophages |
| T133 | 445-446 | -LRB- | denotes | ( |
| T134 | 446-450 | NNS | denotes | MDMs |
| T135 | 450-451 | -RRB- | denotes | ) |
| T136 | 452-455 | CC | denotes | and |
| T137 | 456-459 | DT | denotes | the |
| T138 | 460-466 | NN | denotes | murine |
| T139 | 467-477 | NN | denotes | macrophage |
| T140 | 478-482 | NN | denotes | cell |
| T141 | 483-487 | NN | denotes | line |
| T142 | 488-491 | NNP | denotes | RAW |
| T143 | 492-497 | CD | denotes | 264.7 |
| T144 | 497-498 | . | denotes | . |
| T145 | 499-502 | DT | denotes | The |
| T146 | 503-510 | JJ | denotes | general |
| T147 | 511-518 | NN | denotes | protein |
| T148 | 519-525 | NN | denotes | kinase |
| T149 | 526-527 | NNP | denotes | C |
| T150 | 528-529 | -LRB- | denotes | ( |
| T151 | 529-532 | NNP | denotes | PKC |
| T152 | 532-533 | -RRB- | denotes | ) |
| T153 | 534-543 | NN | denotes | inhibitor |
| T154 | 544-554 | NN | denotes | Ro-31-8220 |
| T155 | 554-555 | , | denotes | , |
| T156 | 556-559 | DT | denotes | the |
| T157 | 560-572 | JJ | denotes | conventional |
| T158 | 573-577 | NNP | denotes | PKCα |
| T159 | 577-578 | NN | denotes | / |
| T160 | 578-579 | NN | denotes | β |
| T161 | 580-589 | NN | denotes | inhibitor |
| T162 | 590-597 | NNP | denotes | Gö-6976 |
| T163 | 597-598 | , | denotes | , |
| T164 | 599-613 | NN | denotes | overexpression |
| T165 | 614-616 | IN | denotes | of |
| T166 | 617-625 | JJ | denotes | dominant |
| T167 | 626-634 | JJ | denotes | negative |
| T168 | 635-639 | NNP | denotes | PKCα |
| T169 | 640-650 | NNS | denotes | constructs |
| T170 | 651-654 | CC | denotes | and |
| T171 | 655-659 | NNP | denotes | PKCα |
| T172 | 660-665 | NNP | denotes | siRNA |
| T173 | 666-673 | VBD | denotes | reduced |
| T174 | 674-679 | JJ | denotes | NF-κB |
| T175 | 680-688 | NN | denotes | activity |
| T176 | 689-691 | IN | denotes | in |
| T177 | 692-700 | NN | denotes | response |
| T178 | 701-703 | TO | denotes | to |
| T179 | 704-709 | NNP | denotes | M-CSF |
| T180 | 709-710 | . | denotes | . |
| T181 | 711-724 | RB | denotes | Interestingly |
| T182 | 724-725 | , | denotes | , |
| T183 | 726-736 | JJ | denotes | Ro-31-8220 |
| T184 | 737-744 | JJ | denotes | reduced |
| T185 | 745-751 | NNP | denotes | Ser276 |
| T186 | 752-767 | NN | denotes | phosphorylation |
| T187 | 768-770 | IN | denotes | of |
| T188 | 771-779 | NN | denotes | NF-κBp65 |
| T189 | 780-787 | VBG | denotes | leading |
| T190 | 788-790 | TO | denotes | to |
| T191 | 791-800 | VBN | denotes | decreased |
| T192 | 801-814 | JJ | denotes | M-CSF-induced |
| T193 | 815-823 | NN | denotes | monocyte |
| T194 | 824-832 | NN | denotes | survival |
| T195 | 832-833 | . | denotes | . |
| T196 | 834-836 | IN | denotes | In |
| T197 | 837-841 | DT | denotes | this |
| T198 | 842-848 | NN | denotes | report |
| T199 | 848-849 | , | denotes | , |
| T200 | 850-852 | PRP | denotes | we |
| T201 | 853-861 | VBP | denotes | identify |
| T202 | 862-874 | JJ | denotes | conventional |
| T203 | 875-879 | NNS | denotes | PKCs |
| T204 | 879-880 | , | denotes | , |
| T205 | 881-890 | VBG | denotes | including |
| T206 | 891-895 | NNP | denotes | PKCα |
| T207 | 896-898 | IN | denotes | as |
| T208 | 899-908 | JJ | denotes | important |
| T209 | 909-917 | JJ | denotes | upstream |
| T210 | 918-925 | NNS | denotes | kinases |
| T211 | 926-929 | IN | denotes | for |
| T212 | 930-943 | JJ | denotes | M-CSF-induced |
| T213 | 944-949 | NN | denotes | NF-κB |
| T214 | 950-965 | JJ | denotes | transcriptional |
| T215 | 966-976 | NN | denotes | activation |
| T216 | 976-977 | , | denotes | , |
| T217 | 978-993 | JJ | denotes | NF-κB-regulated |
| T218 | 994-998 | NN | denotes | gene |
| T219 | 999-1009 | NN | denotes | expression |
| T220 | 1009-1010 | , | denotes | , |
| T221 | 1011-1016 | NNP | denotes | NF-κB |
| T222 | 1017-1020 | CD | denotes | p65 |
| T223 | 1021-1027 | NNP | denotes | Ser276 |
| T224 | 1028-1043 | NN | denotes | phosphorylation |
| T225 | 1043-1044 | , | denotes | , |
| T226 | 1045-1048 | CC | denotes | and |
| T227 | 1049-1059 | NN | denotes | macrophage |
| T228 | 1060-1068 | NN | denotes | survival |
| T229 | 1068-1069 | . | denotes | . |
| T230 | 1070-1076 | RB | denotes | Lastly |
| T231 | 1076-1077 | , | denotes | , |
| T232 | 1078-1080 | PRP | denotes | we |
| T233 | 1081-1085 | VBP | denotes | find |
| T234 | 1086-1090 | IN | denotes | that |
| T235 | 1091-1096 | NNP | denotes | NF-κB |
| T236 | 1097-1100 | CD | denotes | p65 |
| T237 | 1101-1107 | NNP | denotes | Ser276 |
| T238 | 1108-1113 | VBZ | denotes | plays |
| T239 | 1114-1116 | DT | denotes | an |
| T240 | 1117-1126 | JJ | denotes | important |
| T241 | 1127-1131 | NN | denotes | role |
| T242 | 1132-1134 | IN | denotes | in |
| T243 | 1135-1140 | JJ | denotes | basal |
| T244 | 1141-1144 | CC | denotes | and |
| T245 | 1145-1161 | JJ | denotes | M-CSF-stimulated |
| T246 | 1162-1167 | NN | denotes | NF-κB |
| T247 | 1168-1178 | NN | denotes | activation |
| T248 | 1179-1181 | IN | denotes | in |
| T249 | 1182-1187 | JJ | denotes | human |
| T250 | 1188-1199 | NN | denotes | mononuclear |
| T251 | 1200-1210 | NNS | denotes | phagocytes |
| T252 | 1210-1211 | . | denotes | . |
| T14520 | 108-320 | JJ | denotes | transcription factor Nuclear Factor-kappaB (NF-κB) is a key regulator of genes involved in M-CSF-induced mononuclear phagocyte survival and this study focused at identifying the mechanism of NF-κB transcriptional |
| T14521 | 321-406 | NN | denotes | activation. Here, we demonstrate that M-CSF stimulated NF-κB transcriptional activity |
| R80 | T112 | T113 | det | the,mechanism |
| R81 | T113 | T111 | dobj | mechanism,identifying |
| R82 | T114 | T113 | prep | of,mechanism |
| R83 | T115 | T117 | amod | NF-κB,activation |
| R84 | T116 | T117 | amod | transcriptional,activation |
| R85 | T117 | T114 | pobj | activation,of |
| R41 | T73 | T75 | nmod | Macrophage,factor |
| R42 | T74 | T75 | amod | colony-stimulating,factor |
| R44 | T76 | T75 | punct | (,factor |
| R45 | T77 | T75 | appos | M-CSF,factor |
| R46 | T78 | T75 | punct | ),factor |
| R47 | T79 | T79 | ROOT | promotes,promotes |
| R48 | T80 | T82 | amod | mononuclear,survival |
| R49 | T81 | T82 | amod | phagocyte,survival |
| R50 | T82 | T79 | dobj | survival,promotes |
| R51 | T83 | T82 | cc | and,survival |
| R52 | T84 | T82 | conj | proliferation,survival |
| R53 | T85 | T79 | punct | .,promotes |
| R54 | T86 | T88 | det | The,factor |
| R55 | T87 | T88 | compound | transcription,factor |
| R56 | T88 | T94 | nsubj | factor,is |
| R57 | T89 | T90 | compound | Nuclear,Factor-kappaB |
| R58 | T90 | T88 | appos | Factor-kappaB,factor |
| R59 | T91 | T92 | punct | (,NF-κB |
| R60 | T92 | T90 | appos | NF-κB,Factor-kappaB |
| R61 | T93 | T90 | punct | ),Factor-kappaB |
| R62 | T94 | T94 | ROOT | is,is |
| R63 | T95 | T97 | det | a,regulator |
| R64 | T96 | T97 | amod | key,regulator |
| R65 | T97 | T94 | attr | regulator,is |
| R66 | T98 | T97 | prep | of,regulator |
| R67 | T99 | T98 | pobj | genes,of |
| R68 | T100 | T99 | acl | involved,genes |
| R69 | T101 | T100 | prep | in,involved |
| R70 | T102 | T105 | amod | M-CSF-induced,survival |
| R71 | T103 | T105 | compound | mononuclear,survival |
| R72 | T104 | T105 | compound | phagocyte,survival |
| R73 | T105 | T101 | pobj | survival,in |
| R74 | T106 | T94 | cc | and,is |
| R75 | T107 | T108 | det | this,study |
| R76 | T108 | T109 | nsubj | study,focused |
| R77 | T109 | T94 | conj | focused,is |
| R78 | T110 | T109 | prep | at,focused |
| R79 | T111 | T110 | pcomp | identifying,at |
| R86 | T118 | T109 | punct | .,focused |
| R87 | T119 | T122 | advmod | Here,demonstrate |
| R88 | T120 | T122 | punct | ",",demonstrate |
| R89 | T121 | T122 | nsubj | we,demonstrate |
| R90 | T122 | T122 | ROOT | demonstrate,demonstrate |
| R91 | T123 | T125 | mark | that,stimulated |
| R92 | T124 | T125 | nsubj | M-CSF,stimulated |
| R93 | T125 | T122 | ccomp | stimulated,demonstrate |
| R94 | T126 | T128 | compound | NF-κB,activity |
| R95 | T127 | T128 | compound | transcriptional,activity |
| R96 | T128 | T125 | dobj | activity,stimulated |
| R97 | T129 | T128 | prep | in,activity |
| R98 | T130 | T132 | amod | human,macrophages |
| R99 | T131 | T132 | amod | monocyte-derived,macrophages |
| R100 | T132 | T129 | pobj | macrophages,in |
| R101 | T133 | T134 | punct | (,MDMs |
| R102 | T134 | T132 | appos | MDMs,macrophages |
| R103 | T135 | T125 | punct | ),stimulated |
| R104 | T136 | T125 | cc | and,stimulated |
| R105 | T137 | T142 | det | the,RAW |
| R106 | T138 | T141 | nmod | murine,line |
| R107 | T139 | T141 | compound | macrophage,line |
| R108 | T140 | T141 | compound | cell,line |
| R109 | T141 | T142 | compound | line,RAW |
| R110 | T142 | T125 | conj | RAW,stimulated |
| R111 | T143 | T142 | nummod | 264.7,RAW |
| R112 | T144 | T122 | punct | .,demonstrate |
| R113 | T145 | T147 | det | The,protein |
| R114 | T146 | T147 | amod | general,protein |
| R115 | T147 | T173 | nsubj | protein,reduced |
| R116 | T148 | T149 | compound | kinase,C |
| R117 | T149 | T147 | appos | C,protein |
| R118 | T150 | T149 | punct | (,C |
| R119 | T151 | T149 | appos | PKC,C |
| R120 | T152 | T149 | punct | ),C |
| R121 | T153 | T154 | compound | inhibitor,Ro-31-8220 |
| R122 | T154 | T149 | appos | Ro-31-8220,C |
| R123 | T155 | T149 | punct | ",",C |
| R124 | T156 | T162 | det | the,Gö-6976 |
| R125 | T157 | T162 | amod | conventional,Gö-6976 |
| R126 | T158 | T162 | compound | PKCα,Gö-6976 |
| R127 | T159 | T162 | compound | /,Gö-6976 |
| R128 | T160 | T162 | compound | β,Gö-6976 |
| R129 | T161 | T162 | compound | inhibitor,Gö-6976 |
| R130 | T162 | T149 | appos | Gö-6976,C |
| R131 | T163 | T162 | punct | ",",Gö-6976 |
| R132 | T164 | T162 | appos | overexpression,Gö-6976 |
| R133 | T165 | T164 | prep | of,overexpression |
| R134 | T166 | T169 | amod | dominant,constructs |
| R135 | T167 | T169 | amod | negative,constructs |
| R136 | T168 | T169 | compound | PKCα,constructs |
| R137 | T169 | T165 | pobj | constructs,of |
| R138 | T170 | T169 | cc | and,constructs |
| R139 | T171 | T172 | compound | PKCα,siRNA |
| R140 | T172 | T173 | nsubj | siRNA,reduced |
| R141 | T173 | T173 | ROOT | reduced,reduced |
| R142 | T174 | T175 | amod | NF-κB,activity |
| R143 | T175 | T173 | dobj | activity,reduced |
| R144 | T176 | T173 | prep | in,reduced |
| R145 | T177 | T176 | pobj | response,in |
| R146 | T178 | T177 | prep | to,response |
| R147 | T179 | T178 | pobj | M-CSF,to |
| R148 | T180 | T173 | punct | .,reduced |
| R149 | T181 | T184 | advmod | Interestingly,reduced |
| R150 | T182 | T184 | punct | ",",reduced |
| R151 | T183 | T184 | nsubj | Ro-31-8220,reduced |
| R152 | T184 | T184 | ROOT | reduced,reduced |
| R153 | T185 | T186 | compound | Ser276,phosphorylation |
| R154 | T186 | T184 | dobj | phosphorylation,reduced |
| R155 | T187 | T186 | prep | of,phosphorylation |
| R156 | T188 | T189 | compound | NF-κBp65,leading |
| R157 | T189 | T187 | pobj | leading,of |
| R158 | T190 | T189 | prep | to,leading |
| R159 | T191 | T194 | amod | decreased,survival |
| R160 | T192 | T194 | amod | M-CSF-induced,survival |
| R161 | T193 | T194 | compound | monocyte,survival |
| R162 | T194 | T190 | pobj | survival,to |
| R163 | T195 | T184 | punct | .,reduced |
| R164 | T196 | T201 | prep | In,identify |
| R165 | T197 | T198 | det | this,report |
| R166 | T198 | T196 | pobj | report,In |
| R167 | T199 | T201 | punct | ",",identify |
| R168 | T200 | T201 | nsubj | we,identify |
| R169 | T201 | T201 | ROOT | identify,identify |
| R170 | T202 | T203 | amod | conventional,PKCs |
| R171 | T203 | T201 | dobj | PKCs,identify |
| R172 | T204 | T203 | punct | ",",PKCs |
| R173 | T205 | T203 | prep | including,PKCs |
| R174 | T206 | T205 | pobj | PKCα,including |
| R175 | T207 | T201 | prep | as,identify |
| R176 | T208 | T210 | amod | important,kinases |
| R177 | T209 | T210 | compound | upstream,kinases |
| R178 | T210 | T207 | pobj | kinases,as |
| R179 | T211 | T210 | prep | for,kinases |
| R180 | T212 | T215 | amod | M-CSF-induced,activation |
| R181 | T213 | T215 | nmod | NF-κB,activation |
| R182 | T214 | T215 | amod | transcriptional,activation |
| R183 | T215 | T211 | pobj | activation,for |
| R184 | T216 | T215 | punct | ",",activation |
| R185 | T217 | T219 | amod | NF-κB-regulated,expression |
| R186 | T218 | T219 | compound | gene,expression |
| R187 | T219 | T215 | conj | expression,activation |
| R188 | T220 | T215 | punct | ",",activation |
| R189 | T221 | T224 | nmod | NF-κB,phosphorylation |
| R190 | T222 | T224 | nummod | p65,phosphorylation |
| R191 | T223 | T224 | compound | Ser276,phosphorylation |
| R192 | T224 | T215 | conj | phosphorylation,activation |
| R193 | T225 | T224 | punct | ",",phosphorylation |
| R194 | T226 | T224 | cc | and,phosphorylation |
| R195 | T227 | T228 | compound | macrophage,survival |
| R196 | T228 | T224 | conj | survival,phosphorylation |
| R197 | T229 | T201 | punct | .,identify |
| R198 | T230 | T233 | advmod | Lastly,find |
| R199 | T231 | T233 | punct | ",",find |
| R200 | T232 | T233 | nsubj | we,find |
| R201 | T233 | T233 | ROOT | find,find |
| R202 | T234 | T238 | mark | that,plays |
| R203 | T235 | T237 | compound | NF-κB,Ser276 |
| R204 | T236 | T237 | compound | p65,Ser276 |
| R205 | T237 | T238 | nsubj | Ser276,plays |
| R206 | T238 | T233 | ccomp | plays,find |
| R207 | T239 | T241 | det | an,role |
| R208 | T240 | T241 | amod | important,role |
| R209 | T241 | T238 | dobj | role,plays |
| R210 | T242 | T241 | prep | in,role |
| R211 | T243 | T247 | amod | basal,activation |
| R212 | T244 | T243 | cc | and,basal |
| R213 | T245 | T243 | conj | M-CSF-stimulated,basal |
| R214 | T246 | T247 | compound | NF-κB,activation |
| R215 | T247 | T242 | pobj | activation,in |
| R216 | T248 | T247 | prep | in,activation |
| R217 | T249 | T250 | amod | human,mononuclear |
| R218 | T250 | T251 | compound | mononuclear,phagocytes |
| R219 | T251 | T248 | pobj | phagocytes,in |
| R220 | T252 | T233 | punct | .,find |
| R10603 | T14520 | T14521 | amod | transcription factor Nuclear Factor-kappaB (NF-κB) is a key regulator of genes involved in M-CSF-induced mononuclear phagocyte survival and this study focused at identifying the mechanism of NF-κB transcriptional,"activation. Here, we demonstrate that M-CSF stimulated NF-κB transcriptional activity" |
test2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T27 | 0-36 | Protein | denotes | Macrophage colony-stimulating factor |
| T28 | 38-43 | Protein | denotes | M-CSF |
| T29 | 199-204 | Protein | denotes | M-CSF |
| T30 | 359-364 | Protein | denotes | M-CSF |
| T31 | 573-577 | Protein | denotes | PKCα |
| T32 | 578-579 | Protein | denotes | β |
| T33 | 580-589 | Negative_regulation | denotes | inhibitor |
| T34 | 617-639 | Protein | denotes | dominant negative PKCα |
| T35 | 655-665 | Protein | denotes | PKCα siRNA |
| T36 | 704-709 | Protein | denotes | M-CSF |
| T37 | 737-744 | Negative_regulation | denotes | reduced |
| T38 | 745-751 | Entity | denotes | Ser276 |
| T39 | 752-767 | Phosphorylation | denotes | phosphorylation |
| T40 | 774-779 | Protein | denotes | κBp65 |
| T41 | 801-806 | Protein | denotes | M-CSF |
| T42 | 891-895 | Protein | denotes | PKCα |
| T43 | 930-935 | Protein | denotes | M-CSF |
| T44 | 1017-1020 | Protein | denotes | p65 |
| T45 | 1021-1027 | Entity | denotes | Ser276 |
| T46 | 1028-1043 | Phosphorylation | denotes | phosphorylation |
| T47 | 1097-1100 | Protein | denotes | p65 |
| T48 | 1101-1107 | Entity | denotes | Ser276 |
| T49 | 1145-1150 | Protein | denotes | M-CSF |
| R17 | T28 | T27 | equivalentTo | M-CSF,Macrophage colony-stimulating factor |
| R18 | T31 | T33 | themeOf | PKCα,inhibitor |
| R19 | T32 | T33 | themeOf | β,inhibitor |
| R20 | T38 | T40 | partOf | Ser276,κBp65 |
| R21 | T38 | T39 | themeOf | Ser276,phosphorylation |
| R22 | T39 | T37 | themeOf | phosphorylation,reduced |
| R23 | T45 | T46 | themeOf | Ser276,phosphorylation |
| R24 | T45 | T44 | partOf | Ser276,p65 |
| R25 | T48 | T47 | partOf | Ser276,p65 |