PMC:3220857 / 9888-11646 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/3220857","sourcedb":"PMC","sourceid":"3220857","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3220857","text":"Plasma CETP and (apo)lipoproteins\nWhen compared with baseline, VLCD decreased plasma CETP concentration (−18.2%; P \u003c 0.01). In addition, VLCD reduced plasma levels of total cholesterol (−13.1%; P \u003c 0.001), TG (−45.1%; P \u003c 0.001), phospholipid (−15.2%; P \u003c 0.0001), LDL-cholesterol (−15.8%; P \u003c 0.01), and apoB100 (−13.9%; P \u003c 0.01). VLCD did not alter plasma HDL-cholesterol and HDL-phospholipids, but increased apoAI (+16.2%; P \u003c 0.05) (Table 1). The change in body weight after 16 weeks of VLCD did not correlate with the change in either plasma TG (R2 = 0.0000; P = 0.9952), total cholesterol (R2 = 0.0471; P = 0.2769), phospholipid (R2 = 0.0305; P = 0.3837), LDL-cholesterol (R2 = 0.0320; P = 0.3717), HDL-cholesterol (R2 = 0.0086; P = 0.6460), or HDL-phospholipid (R2 = 0.0013; P = 0.8570).\nTable 1 Plasma CETP and (apo)lipoprotein levels in obese patients with type 2 diabetes mellitus and hepatic steatosis in response to 16 weeks of VLCD\nPlasma parameters Baseline After VLCD Δ (%) P value\nCETP (μg/mL) 2.48 ± 0.15 2.03 ± 0.14 −18.2 0.0021\nTotal cholesterol (mmol/L) 5.76 ± 0.30 5.00 ± 0.22 −13.1 0.0007\nTriglycerides (mmol/L) 2.41 ± 0.28 1.32 ± 0.10 −45.1 0.0003\nPhospholipids (mmol/L) 2.69 ± 0.11 2.28 ± 0.07 −15.2 0.0000\nLDL-cholesterol (mmol/L) 3.99 ± 0.27 3.36 ± 0.20 −15.8 0.0028\nApoB100 (mg/dL) 130 ± 6 111 ± 5 −13.9 0.0016\nHDL-cholesterol (mmol/L) 0.84 ± 0.04 0.91 ± 0.06 — NS\nHDL-phospholipids (mmol/L) 0.98 ± 0.03 0.98 ± 0.05 — NS\nApoAI (mg/dL) 135 ± 10 156 ± 11 +16.2 0.0174\nData are presented as means ± SEM (n = 27). Δ values are calculated by comparing values obtained after VLCD with those obtained at baseline from obese patients with type 2 diabetes mellitus. P values are calculated using paired Student t test. NS, not significant.","divisions":[{"label":"title","span":{"begin":0,"end":33}},{"label":"p","span":{"begin":34,"end":795}},{"label":"label","span":{"begin":796,"end":803}},{"label":"caption","span":{"begin":804,"end":945}},{"label":"p","span":{"begin":804,"end":945}},{"label":"table","span":{"begin":946,"end":1493}},{"label":"tr","span":{"begin":946,"end":997}},{"label":"th","span":{"begin":946,"end":963}},{"label":"th","span":{"begin":964,"end":972}},{"label":"th","span":{"begin":973,"end":983}},{"label":"th","span":{"begin":984,"end":989}},{"label":"th","span":{"begin":990,"end":997}},{"label":"tr","span":{"begin":998,"end":1047}},{"label":"td","span":{"begin":998,"end":1010}},{"label":"td","span":{"begin":1011,"end":1022}},{"label":"td","span":{"begin":1023,"end":1034}},{"label":"td","span":{"begin":1035,"end":1040}},{"label":"td","span":{"begin":1041,"end":1047}},{"label":"tr","span":{"begin":1048,"end":1111}},{"label":"td","span":{"begin":1048,"end":1074}},{"label":"td","span":{"begin":1075,"end":1086}},{"label":"td","span":{"begin":1087,"end":1098}},{"label":"td","span":{"begin":1099,"end":1104}},{"label":"td","span":{"begin":1105,"end":1111}},{"label":"tr","span":{"begin":1112,"end":1171}},{"label":"td","span":{"begin":1112,"end":1134}},{"label":"td","span":{"begin":1135,"end":1146}},{"label":"td","span":{"begin":1147,"end":1158}},{"label":"td","span":{"begin":1159,"end":1164}},{"label":"td","span":{"begin":1165,"end":1171}},{"label":"tr","span":{"begin":1172,"end":1231}},{"label":"td","span":{"begin":1172,"end":1194}},{"label":"td","span":{"begin":1195,"end":1206}},{"label":"td","span":{"begin":1207,"end":1218}},{"label":"td","span":{"begin":1219,"end":1224}},{"label":"td","span":{"begin":1225,"end":1231}},{"label":"tr","span":{"begin":1232,"end":1293}},{"label":"td","span":{"begin":1232,"end":1256}},{"label":"td","span":{"begin":1257,"end":1268}},{"label":"td","span":{"begin":1269,"end":1280}},{"label":"td","span":{"begin":1281,"end":1286}},{"label":"td","span":{"begin":1287,"end":1293}},{"label":"tr","span":{"begin":1294,"end":1338}},{"label":"td","span":{"begin":1294,"end":1309}},{"label":"td","span":{"begin":1310,"end":1317}},{"label":"td","span":{"begin":1318,"end":1325}},{"label":"td","span":{"begin":1326,"end":1331}},{"label":"td","span":{"begin":1332,"end":1338}},{"label":"tr","span":{"begin":1339,"end":1392}},{"label":"td","span":{"begin":1339,"end":1363}},{"label":"td","span":{"begin":1364,"end":1375}},{"label":"td","span":{"begin":1376,"end":1387}},{"label":"td","span":{"begin":1388,"end":1389}},{"label":"td","span":{"begin":1390,"end":1392}},{"label":"tr","span":{"begin":1393,"end":1448}},{"label":"td","span":{"begin":1393,"end":1419}},{"label":"td","span":{"begin":1420,"end":1431}},{"label":"td","span":{"begin":1432,"end":1443}},{"label":"td","span":{"begin":1444,"end":1445}},{"label":"td","span":{"begin":1446,"end":1448}},{"label":"tr","span":{"begin":1449,"end":1493}},{"label":"td","span":{"begin":1449,"end":1462}},{"label":"td","span":{"begin":1463,"end":1471}},{"label":"td","span":{"begin":1472,"end":1480}},{"label":"td","span":{"begin":1481,"end":1486}},{"label":"td","span":{"begin":1487,"end":1493}}],"tracks":[]}