PMC:3218875 / 8540-10724 JSON TXT

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testone

Id	Subject	Object	Predicate	Lexical cue
T19331	1776-1785	Negative_regulation	denotes	inhibitor
T19330	1470-1477	Binding	denotes	binding
T19329	1448-1455	Negative_regulation	denotes	compete
T19328	1374-1383	Negative_regulation	denotes	inhibited
T19327	1307-1317	Gene_expression	denotes	expression
T19326	1296-1306	Negative_regulation	denotes	inhibiting
T19325	1187-1194	Binding	denotes	binding
T19324	1152-1161	Binding	denotes	recruited
T19323	816-823	Entity	denotes	nucleus
T19322	797-808	Localization	denotes	translocate
T19321	718-729	Protein_catabolism	denotes	degradation
T19320	640-654	Phosphorylation	denotes	phosphorylates
T19319	289-297	Positive_regulation	denotes	inducing
T19318	149-160	Binding	denotes	recruitment
T19317	137-144	Positive_regulation	denotes	trigger
T19316	59-69	Binding	denotes	engagement
T19315	2161-2183	Protein	denotes	tumour necrosis factor
T19314	2156-2159	Protein	denotes	TNF
T19313	2018-2060	Protein	denotes	single-immunoglobulinIL-1 receptor-related
T19312	2010-2016	Protein	denotes	SIGIRR
T19311	1978-2008	Protein	denotes	receptor interacting protein 1
T19310	1972-1976	Protein	denotes	RIP1
T19309	1943-1970	Protein	denotes	receptor activator of NF-κB
T19308	1937-1941	Protein	denotes	RANK
T19307	1890-1915	Protein	denotes	NF-κB essential modulator
T19306	1884-1888	Protein	denotes	NEMO
T19305	1834-1882	Protein	denotes	myeloid differentiation primary response gene 88
T19304	1827-1832	Protein	denotes	MyD88
T19303	1737-1752	Protein	denotes	cylindromatosis
T19302	1731-1735	Protein	denotes	CYLD
T19301	1660-1690	Protein	denotes	A20-binding inhibitor of NF-κB
T19300	1654-1658	Protein	denotes	ABIN
T19299	1491-1496	Protein	denotes	TRAF6
T19298	1481-1486	Protein	denotes	IRAK1
T19297	1461-1465	Protein	denotes	TLR4
T19296	1413-1419	Protein	denotes	SIGIRR
T19295	1331-1336	Protein	denotes	TRAF6
T19294	1321-1326	Protein	denotes	IRAK1
T19293	1231-1234	Protein	denotes	p62
T19292	1220-1226	Protein	denotes	ABIN-1
T19291	1127-1132	Protein	denotes	TRAF6
T19290	1118-1122	Protein	denotes	RIP1
T19289	1002-1006	Protein	denotes	CYLD
T19288	994-997	Protein	denotes	A20
T19287	860-865	Protein	denotes	TRAF1
T19286	789-792	Protein	denotes	p50
T19285	781-784	Protein	denotes	p65
T19284	655-659	Protein	denotes	IκBα
T19283	620-624	Protein	denotes	IKK2
T19282	581-585	Protein	denotes	TAK1
T19281	575-579	Protein	denotes	TAK1
T19280	566-570	Protein	denotes	IKK2
T19279	483-487	Protein	denotes	NEMO
T19278	459-464	Protein	denotes	IRAK1
T19277	450-454	Protein	denotes	RIP1
T19276	386-391	Protein	denotes	cIAP2
T19275	379-384	Protein	denotes	cIAP1
T19274	372-377	Protein	denotes	TRAF6
T19273	365-370	Protein	denotes	TRAF2
T19272	334-339	Protein	denotes	IRAK4
T19271	327-332	Protein	denotes	IRAK1
T19270	321-325	Protein	denotes	RIP1
T19269	304-308	Protein	denotes	TRIF
T19268	259-302	Protein	denotes	TIR domain-containing adaptor-inducing IFNβ
T19267	254-257	Protein	denotes	MAL
T19266	247-252	Protein	denotes	MyD88
T19265	239-244	Protein	denotes	TRADD
T19264	191-237	Protein	denotes	TNF receptor 1-associated death domain protein
T19263	132-136	Protein	denotes	TLR4
T19262	122-126	Protein	denotes	RANK
T19261	116-120	Protein	denotes	CD40
T19260	109-114	Protein	denotes	TNFR1
R12749	T19260	T19316	themeOf	TNFR1,engagement
R12750	T19261	T19316	themeOf	CD40,engagement
R12751	T19262	T19316	themeOf	RANK,engagement
R12752	T19263	T19317	causeOf	TLR4,trigger
R12753	T19263	T19316	themeOf	TLR4,engagement
R12754	T19264	T19318	themeOf	TNF receptor 1-associated death domain protein,recruitment
R12755	T19266	T19318	themeOf	MyD88,recruitment
R12756	T19267	T19318	themeOf	MAL,recruitment
R12757	T19268	T19318	themeOf	TIR domain-containing adaptor-inducing IFNβ,recruitment
R12758	T19269	T19268	equivalentTo	TRIF,TIR domain-containing adaptor-inducing IFNβ
R12759	T19270	T19268	equivalentTo	RIP1,TIR domain-containing adaptor-inducing IFNβ
R12760	T19271	T19318	themeOf	IRAK1,recruitment
R12761	T19272	T19318	themeOf	IRAK4,recruitment
R12762	T19273	T19268	equivalentTo	TRAF2,TIR domain-containing adaptor-inducing IFNβ
R12763	T19274	T19318	themeOf	TRAF6,recruitment
R12764	T19275	T19318	themeOf	cIAP1,recruitment
R12765	T19276	T19318	themeOf	cIAP2,recruitment
R12766	T19283	T19321	themeOf	IKK2,degradation
R12767	T19284	T19320	themeOf	IκBα,phosphorylates
R12768	T19285	T19322	themeOf	p65,translocate
R12769	T19286	T19322	themeOf	p50,translocate
R12770	T19290	T19324	themeOf	RIP1,recruited
R12771	T19291	T19324	themeOf	TRAF6,recruited
R12772	T19292	T19324	themeOf	ABIN-1,recruited
R12773	T19293	T19324	themeOf	p62,recruited
R12774	T19294	T19327	themeOf	IRAK1,expression
R12775	T19295	T19327	themeOf	TRAF6,expression
R12776	T19296	T19328	causeOf	SIGIRR,inhibited
R12777	T19297	T19330	themeOf	TLR4,binding
R12778	T19298	T19330	themeOf	IRAK1,binding
R12779	T19299	T19330	themeOf	TRAF6,binding
R12780	T19304	T19331	themeOf	MyD88,inhibitor
R12781	T19305	T19331	themeOf	myeloid differentiation primary response gene 88,inhibitor
R12782	T19306	T19331	themeOf	NEMO,inhibitor
R12783	T19307	T19331	themeOf	NF-κB essential modulator,inhibitor
R12784	T19308	T19331	themeOf	RANK,inhibitor
R12785	T19309	T19331	themeOf	receptor activator of NF-κB,inhibitor
R12786	T19309	T19308	themeOf	receptor activator of NF-κB,RANK
R12787	T19310	T19331	themeOf	RIP1,inhibitor
R12788	T19311	T19331	themeOf	receptor interacting protein 1,inhibitor
R12789	T19312	T19331	themeOf	SIGIRR,inhibitor
R12790	T19313	T19331	themeOf	single-immunoglobulinIL-1 receptor-related,inhibitor
R12791	T19314	T19308	themeOf	TNF,RANK
R12792	T19314	T19331	themeOf	TNF,inhibitor
R12793	T19315	T19331	themeOf	tumour necrosis factor,inhibitor
R12794	T19318	T19317	themeOf	recruitment,trigger
R12795	T19319	T19317	themeOf	inducing,trigger
R12796	T19323	T19322	locationOf	nucleus,translocate
R12797	T19327	T19326	themeOf	expression,inhibiting
R12798	T19330	T19329	themeOf	binding,compete

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T20557	2183-2184	.	denotes	.
T20556	2177-2183	NN	denotes	factor
T20555	2168-2176	NN	denotes	necrosis
T20554	2161-2167	NN	denotes	tumour
T20553	2159-2160	,	denotes	,
T20552	2156-2159	NNP	denotes	TNF
T20551	2154-2155	:	denotes	;
T20550	2146-2154	NN	denotes	receptor
T20549	2136-2145	JJ	denotes	Toll-like
T20548	2134-2135	,	denotes	,
T20547	2131-2134	NNP	denotes	TLR
T20546	2129-2130	:	denotes	;
T20545	2123-2129	NN	denotes	factor
T20544	2103-2122	VBD	denotes	receptor-associated
T20543	2099-2102	NNP	denotes	TNF
T20542	2097-2098	,	denotes	,
T20541	2093-2097	NNP	denotes	TRAF
T20540	2091-2092	:	denotes	;
T20539	2090-2091	NN	denotes	R
T20538	2088-2090	CD	denotes	-1
T20537	2077-2088	NNP	denotes	receptor/IL
T20536	2067-2076	JJ	denotes	Toll-like
T20535	2065-2066	,	denotes	,
T20534	2062-2065	NNP	denotes	TIR
T20533	2060-2061	:	denotes	;
T20532	2044-2060	JJ	denotes	receptor-related
T20531	2018-2043	JJ	denotes	single-immunoglobulinIL-1
T20530	2016-2017	,	denotes	,
T20529	2010-2016	NNP	denotes	SIGIRR
T20528	2008-2009	:	denotes	;
T20527	2007-2008	CD	denotes	1
T20526	1999-2006	NN	denotes	protein
T20525	1987-1998	VBG	denotes	interacting
T20524	1978-1986	NN	denotes	receptor
T20523	1976-1977	,	denotes	,
T20522	1972-1976	NNP	denotes	RIP1
T20521	1970-1971	:	denotes	;
T20520	1965-1970	NNP	denotes	NF-κB
T20519	1962-1964	IN	denotes	of
T20518	1952-1961	NN	denotes	activator
T20517	1943-1951	NN	denotes	receptor
T20516	1941-1942	,	denotes	,
T20515	1937-1941	NNP	denotes	RANK
T20514	1935-1936	:	denotes	;
T20513	1929-1935	NN	denotes	factor
T20512	1921-1928	JJ	denotes	nuclear
T20511	1919-1920	,	denotes	,
T20510	1917-1919	NNP	denotes	NF
T20509	1915-1916	:	denotes	;
T20508	1906-1915	NN	denotes	modulator
T20507	1896-1905	JJ	denotes	essential
T20506	1890-1895	NNP	denotes	NF-κB
T20505	1888-1889	,	denotes	,
T20504	1884-1888	NNP	denotes	NEMO
T20503	1882-1883	:	denotes	;
T20502	1880-1882	CD	denotes	88
T20501	1875-1879	NN	denotes	gene
T20500	1866-1874	NN	denotes	response
T20499	1858-1865	JJ	denotes	primary
T20498	1842-1857	NN	denotes	differentiation
T20497	1834-1841	JJ	denotes	myeloid
T20496	1832-1833	,	denotes	,
T20495	1827-1832	NNP	denotes	MyD88
T20494	1825-1826	:	denotes	;
T20493	1819-1825	NN	denotes	kinase
T20492	1802-1818	JJ	denotes	IL-1R-associated
T20491	1800-1801	,	denotes	,
T20490	1796-1800	NNP	denotes	IRAK
T20489	1794-1795	:	denotes	;
T20488	1789-1794	NN	denotes	NF-κB
T20487	1786-1788	IN	denotes	of
T20486	1776-1785	NN	denotes	inhibitor
T20485	1774-1775	,	denotes	,
T20484	1771-1774	NNP	denotes	IκB
T20483	1769-1770	:	denotes	;
T20482	1763-1769	NN	denotes	kinase
T20481	1759-1762	NNP	denotes	IκB
T20480	1757-1758	,	denotes	,
T20479	1754-1757	NNP	denotes	IKK
T20478	1752-1753	:	denotes	;
T20477	1737-1752	NN	denotes	cylindromatosis
T20476	1735-1736	,	denotes	,
T20475	1731-1735	NNP	denotes	CYLD
T20474	1729-1730	:	denotes	;
T20473	1720-1729	NN	denotes	apoptosis
T20472	1717-1719	IN	denotes	of
T20471	1707-1716	NN	denotes	inhibitor
T20470	1698-1706	JJ	denotes	cellular
T20469	1696-1697	,	denotes	,
T20468	1692-1696	NNP	denotes	cIAP
T20467	1690-1691	:	denotes	;
T20466	1685-1690	NN	denotes	NF-κB
T20465	1682-1684	IN	denotes	of
T20464	1672-1681	NN	denotes	inhibitor
T20463	1660-1671	JJ	denotes	A20-binding
T20462	1658-1659	,	denotes	,
T20461	1654-1658	NNP	denotes	ABIN
T20460	1652-1653	.	denotes	.
T20459	1642-1652	NN	denotes	activation
T20404	1321-1326	NNP	denotes	IRAK1
T20403	1318-1320	IN	denotes	of
T20402	1307-1317	NN	denotes	expression
T20401	1296-1306	VBG	denotes	inhibiting
T20400	1293-1295	IN	denotes	by
T20399	1282-1292	JJ	denotes	signalling
T20398	1278-1281	NNP	denotes	TLR
T20397	1269-1277	VB	denotes	regulate
T20396	1258-1268	RB	denotes	negatively
T20395	1255-1257	TO	denotes	to
T20394	1247-1254	VBN	denotes	thought
T20393	1244-1246	VBZ	denotes	is
T20392	1236-1243	NN	denotes	miR-146
T20391	1234-1235	.	denotes	.
T20390	1231-1234	CD	denotes	p62
T20389	1227-1230	CC	denotes	and
T20388	1220-1226	NNP	denotes	ABIN-1
T20387	1217-1219	IN	denotes	as
T20386	1212-1216	JJ	denotes	such
T20385	1203-1211	NNS	denotes	proteins
T20384	1195-1202	NN	denotes	adaptor
T20383	1177-1194	JJ	denotes	ubiquitin-binding
T20382	1168-1176	JJ	denotes	specific
T20381	1162-1167	VBG	denotes	using
T20380	1152-1161	VBN	denotes	recruited
T20379	1148-1151	VBP	denotes	are
T20378	1143-1147	PRP	denotes	they
T20377	1137-1142	WDT	denotes	which
T20376	1134-1136	TO	denotes	to
T20375	1132-1133	,	denotes	,
T20374	1127-1132	NNP	denotes	TRAF6
T20373	1123-1126	CC	denotes	and
T20372	1118-1122	NNP	denotes	RIP1
T20371	1108-1117	VBG	denotes	including
T20370	1099-1107	NNS	denotes	proteins
T20369	1088-1098	VBG	denotes	signalling
T20368	1079-1087	JJ	denotes	specific
T20367	1069-1078	VBG	denotes	targeting
T20366	1066-1068	IN	denotes	by
T20365	1055-1065	NN	denotes	activation
T20364	1049-1054	JJ	denotes	NF-κB
T20363	1041-1048	VBP	denotes	control
T20362	1036-1040	WDT	denotes	that
T20361	1028-1035	NNS	denotes	enzymes
T20360	1011-1027	VBG	denotes	deubiquitinating
T20359	1007-1010	VBP	denotes	are
T20358	1002-1006	NNP	denotes	CYLD
T20357	998-1001	CC	denotes	and
T20356	994-997	CD	denotes	A20
T20355	992-993	.	denotes	.
T20354	987-992	NNS	denotes	TRAFs
T20353	981-986	JJ	denotes	other
T20352	976-980	IN	denotes	with
T20351	966-975	VBG	denotes	competing
T20350	963-965	IN	denotes	by
T20349	954-962	RB	denotes	probably
T20348	949-953	JJS	denotes	most
T20347	947-948	,	denotes	,
T20346	937-947	NN	denotes	activation
T20345	931-936	JJ	denotes	NF-κB
T20344	922-930	VB	denotes	regulate
T20343	911-921	RB	denotes	negatively
T20342	907-910	MD	denotes	can
T20341	905-906	,	denotes	,
T20340	897-905	NN	denotes	activity
T20339	890-896	NN	denotes	ligase
T20338	880-889	NN	denotes	ubiquitin
T20337	877-879	DT	denotes	no
T20336	873-876	VBZ	denotes	has
T20335	867-872	WDT	denotes	which
T20334	865-866	,	denotes	,
T20333	860-865	CD	denotes	TRAF1
T20332	858-859	.	denotes	.
T20331	848-858	NN	denotes	expression
T20330	843-847	NN	denotes	gene
T20329	836-842	NN	denotes	target
T20328	828-835	VB	denotes	promote
T20327	824-827	CC	denotes	and
T20326	816-823	NN	denotes	nucleus
T20325	812-815	DT	denotes	the
T20324	809-811	TO	denotes	to
T20323	797-808	VB	denotes	translocate
T20322	794-796	TO	denotes	to
T20321	792-793	-RRB-	denotes	)
T20320	789-792	CD	denotes	p50
T20319	785-788	CC	denotes	and
T20318	781-784	CD	denotes	p65
T20317	778-780	IN	denotes	of
T20316	766-777	NN	denotes	heterodimer
T20315	764-765	DT	denotes	a
T20314	761-763	IN	denotes	as
T20313	755-760	VBN	denotes	shown
T20312	750-754	RB	denotes	here
T20311	749-750	-LRB-	denotes	(
T20310	743-748	NNP	denotes	NF-κB
T20309	736-742	VBZ	denotes	allows
T20308	731-735	DT	denotes	This
T20307	729-730	.	denotes	.
T20306	718-729	NN	denotes	degradation
T20305	706-717	JJ	denotes	proteasomal
T20304	702-705	CC	denotes	and
T20303	687-701	NN	denotes	ubiquitination
T20302	676-686	JJ	denotes	K48-linked
T20301	672-675	PRP$	denotes	its
T20300	661-671	VBG	denotes	triggering
T20299	659-660	,	denotes	,
T20298	655-659	NNP	denotes	IκBα
T20297	640-654	NNS	denotes	phosphorylates
T20296	635-639	NN	denotes	turn
T20295	632-634	IN	denotes	in
T20294	626-631	WDT	denotes	which
T20293	624-625	,	denotes	,
T20292	620-624	NNP	denotes	IKK2
T20291	610-619	VBZ	denotes	activates
T20290	606-609	CC	denotes	and
T20289	591-605	VBZ	denotes	phosphorylates
T20288	586-590	RB	denotes	then
T20287	581-585	CD	denotes	TAK1
T20286	579-580	.	denotes	.
T20285	575-579	CD	denotes	TAK1
T20284	571-574	CC	denotes	and
T20283	566-570	CD	denotes	IKK2
T20282	553-565	RB	denotes	respectively
T20281	550-552	IN	denotes	of
T20280	539-549	NN	denotes	activation
T20279	535-538	CC	denotes	and
T20278	523-534	NN	denotes	recruitment
T20277	519-522	DT	denotes	the
T20276	516-518	IN	denotes	in
T20275	506-515	VBG	denotes	resulting
T20274	504-505	,	denotes	,
T20273	496-504	NNS	denotes	proteins
T20272	492-495	NNP	denotes	TAB
T20271	488-491	CC	denotes	and
T20270	483-487	NNP	denotes	NEMO
T20269	480-482	IN	denotes	by
T20268	469-479	VBN	denotes	recognised
T20267	466-468	VBZ	denotes	is
T20266	464-465	,	denotes	,
T20265	459-464	NNP	denotes	IRAK1
T20264	455-458	CC	denotes	and
T20263	450-454	NNP	denotes	RIP1
T20262	448-449	,	denotes	,
T20261	443-448	NNP	denotes	TRAFs
T20260	440-442	IN	denotes	of
T20259	421-439	NN	denotes	polyubiquitination
T20258	410-420	JJ	denotes	K63-linked
T20257	408-409	.	denotes	.
T20256	400-408	NN	denotes	receptor
T20255	396-399	DT	denotes	the
T20254	393-395	TO	denotes	to
T20253	391-392	-RRB-	denotes	)
T20252	386-391	NNP	denotes	cIAP2
T20251	384-385	,	denotes	,
T20250	379-384	NNP	denotes	cIAP1
T20249	377-378	,	denotes	,
T20248	372-377	CD	denotes	TRAF6
T20247	370-371	,	denotes	,
T20246	365-370	CD	denotes	TRAF2
T20245	364-365	-LRB-	denotes	(
T20244	356-363	NNS	denotes	ligases
T20243	346-355	NN	denotes	ubiquitin
T20242	342-345	CC	denotes	and
T20241	340-341	,	denotes	,
T20240	339-340	-RRB-	denotes	)
T20239	334-339	NNP	denotes	IRAK4
T20238	332-333	,	denotes	,
T20237	327-332	NNP	denotes	IRAK1
T20236	325-326	,	denotes	,
T20235	321-325	CD	denotes	RIP1
T20234	320-321	-LRB-	denotes	(
T20233	312-319	NNS	denotes	kinases
T20232	310-311	,	denotes	,
T20231	309-310	-RRB-	denotes	)
T20230	308-309	-RRB-	denotes	)
T20229	304-308	NNP	denotes	TRIF
T20228	303-304	-LRB-	denotes	(
T20227	298-302	NNP	denotes	IFNβ
T20226	281-297	JJ	denotes	adaptor-inducing
T20225	263-280	JJ	denotes	domain-containing
T20224	259-262	NNP	denotes	TIR
T20223	257-258	,	denotes	,
T20222	254-257	NNP	denotes	MAL
T20221	252-253	,	denotes	,
T20220	247-252	NNP	denotes	MyD88
T20219	245-246	,	denotes	,
T20218	244-245	-RRB-	denotes	)
T20217	239-244	NNP	denotes	TRADD
T20216	238-239	-LRB-	denotes	(
T20215	230-237	NN	denotes	protein
T20214	223-229	NN	denotes	domain
T20213	217-222	NN	denotes	death
T20212	204-216	JJ	denotes	1-associated
T20211	195-203	NN	denotes	receptor
T20210	191-194	NN	denotes	TNF
T20209	190-191	-LRB-	denotes	(
T20208	181-189	NNS	denotes	proteins
T20207	173-180	NN	denotes	adaptor
T20206	164-172	JJ	denotes	specific
T20205	161-163	IN	denotes	of
T20204	149-160	NN	denotes	recruitment
T20203	145-148	DT	denotes	the
T20202	137-144	NN	denotes	trigger
T20201	132-136	CD	denotes	TLR4
T20200	128-131	CC	denotes	and
T20199	126-127	,	denotes	,
T20198	122-126	NNP	denotes	RANK
T20197	120-121	,	denotes	,
T20196	116-120	NNP	denotes	CD40
T20195	114-115	,	denotes	,
T20194	109-114	CD	denotes	TNFR1
T20193	106-108	IN	denotes	as
T20192	101-105	JJ	denotes	such
T20191	91-100	NNS	denotes	receptors
T20190	82-90	NN	denotes	membrane
T20189	73-81	JJ	denotes	specific
T20458	1636-1641	JJ	denotes	NF-κB
T20457	1633-1635	IN	denotes	of
T20456	1622-1632	NN	denotes	regulation
T20455	1613-1621	NN	denotes	feedback
T20454	1604-1612	JJ	denotes	negative
T20453	1600-1603	DT	denotes	the
T20452	1597-1599	IN	denotes	in
T20451	1592-1596	PRP	denotes	them
T20450	1580-1591	VBG	denotes	implicating
T20449	1578-1579	,	denotes	,
T20448	1569-1578	JJ	denotes	dependent
T20447	1563-1568	JJ	denotes	NF-κB
T20446	1560-1562	VBZ	denotes	is
T20445	1550-1559	NNS	denotes	molecules
T20444	1539-1549	JJ	denotes	regulatory
T20443	1530-1538	JJ	denotes	negative
T20442	1524-1529	DT	denotes	these
T20441	1521-1523	IN	denotes	of
T20440	1516-1520	JJ	denotes	many
T20439	1513-1515	IN	denotes	of
T20438	1502-1512	NN	denotes	expression
T20437	1498-1501	DT	denotes	The
T20436	1496-1497	.	denotes	.
T20435	1491-1496	NNP	denotes	TRAF6
T20434	1487-1490	CC	denotes	and
T20433	1481-1486	NNP	denotes	IRAK1
T20432	1478-1480	TO	denotes	to
T20431	1470-1477	JJ	denotes	binding
T20430	1466-1469	IN	denotes	for
T20429	1461-1465	CD	denotes	TLR4
T20428	1456-1460	IN	denotes	with
T20427	1448-1455	VB	denotes	compete
T20426	1445-1447	TO	denotes	to
T20425	1436-1444	VBN	denotes	proposed
T20424	1431-1435	VBN	denotes	been
T20423	1427-1430	VBZ	denotes	has
T20422	1421-1426	WDT	denotes	which
T20421	1419-1420	,	denotes	,
T20420	1413-1419	NNP	denotes	SIGIRR
T20419	1405-1412	NN	denotes	protein
T20418	1391-1404	NN	denotes	transmembrane
T20417	1387-1390	DT	denotes	the
T20416	1384-1386	IN	denotes	by
T20415	1374-1383	VBN	denotes	inhibited
T20414	1371-1373	VB	denotes	be
T20413	1366-1370	RB	denotes	also
T20412	1362-1365	MD	denotes	can
T20411	1351-1361	NN	denotes	signalling
T20410	1347-1350	NNP	denotes	TLR
T20409	1345-1346	,	denotes	,
T20408	1338-1345	RB	denotes	Finally
T20407	1336-1337	.	denotes	.
T20406	1331-1336	NNP	denotes	TRAF6
T20405	1327-1330	CC	denotes	and
T20188	70-72	IN	denotes	of
T20187	59-69	NN	denotes	engagement
T20186	52-58	NNP	denotes	Ligand
T20185	50-51	.	denotes	.
T20184	40-50	NNS	denotes	regulators
T20183	31-39	JJ	denotes	negative
T20182	27-30	CC	denotes	and
T20181	16-26	VBG	denotes	signalling
T20180	10-15	NNP	denotes	NF-κB
T20179	0-9	NNP	denotes	Canonical
R13295	T20179	T20180	compound	Canonical,NF-κB
R13296	T20180	T20181	nsubj	NF-κB,signalling
R13297	T20181	T20181	ROOT	signalling,signalling
R13300	T20184	T20181	dobj	regulators,signalling
R13301	T20185	T20181	punct	.,signalling
R13302	T20186	T20187	compound	Ligand,engagement
R13303	T20187	T20202	dep	engagement,trigger
R13304	T20188	T20187	prep	of,engagement
R13305	T20189	T20191	amod	specific,receptors
R13306	T20190	T20191	compound	membrane,receptors
R13307	T20191	T20188	pobj	receptors,of
R13308	T20192	T20193	amod	such,as
R13309	T20193	T20191	prep	as,receptors
R13310	T20194	T20193	pobj	TNFR1,as
R13311	T20195	T20194	punct	",",TNFR1
R13312	T20196	T20202	nsubj	CD40,trigger
R13313	T20197	T20196	punct	",",CD40
R13314	T20198	T20196	conj	RANK,CD40
R13315	T20199	T20198	punct	",",RANK
R13316	T20200	T20198	cc	and,RANK
R13317	T20201	T20202	nummod	TLR4,trigger
R13318	T20202	T20202	ROOT	trigger,trigger
R13319	T20203	T20204	det	the,recruitment
R13320	T20204	T20202	dobj	recruitment,trigger
R13321	T20205	T20204	prep	of,recruitment
R13322	T20206	T20208	amod	specific,proteins
R13323	T20207	T20208	compound	adaptor,proteins
R13324	T20208	T20205	pobj	proteins,of
R13325	T20209	T20208	punct	(,proteins
R13326	T20210	T20215	compound	TNF,protein
R13327	T20211	T20215	compound	receptor,protein
R13328	T20212	T20214	amod	1-associated,domain
R13329	T20213	T20214	compound	death,domain
R13330	T20214	T20215	compound	domain,protein
R13331	T20215	T20208	appos	protein,proteins
R13332	T20216	T20217	punct	(,TRADD
R13333	T20217	T20215	appos	TRADD,protein
R13334	T20218	T20217	punct	),TRADD
R13335	T20219	T20215	punct	",",protein
R13336	T20220	T20215	appos	MyD88,protein
R13337	T20221	T20220	punct	",",MyD88
R13338	T20222	T20220	conj	MAL,MyD88
R13339	T20223	T20222	punct	",",MAL
R13340	T20224	T20227	compound	TIR,IFNβ
R13341	T20225	T20227	compound	domain-containing,IFNβ
R13342	T20226	T20227	compound	adaptor-inducing,IFNβ
R13343	T20227	T20222	conj	IFNβ,MAL
R13344	T20228	T20229	punct	(,TRIF
R13345	T20229	T20227	appos	TRIF,IFNβ
R13346	T20230	T20229	punct	),TRIF
R13347	T20231	T20227	punct	),IFNβ
R13348	T20232	T20227	punct	",",IFNβ
R13349	T20233	T20227	conj	kinases,IFNβ
R13350	T20234	T20233	punct	(,kinases
R13351	T20235	T20233	appos	RIP1,kinases
R13352	T20236	T20233	punct	",",kinases
R13353	T20237	T20233	conj	IRAK1,kinases
R13354	T20238	T20237	punct	",",IRAK1
R13355	T20239	T20237	conj	IRAK4,IRAK1
R13356	T20240	T20237	punct	),IRAK1
R13357	T20241	T20237	punct	",",IRAK1
R13358	T20242	T20237	cc	and,IRAK1
R13359	T20243	T20244	compound	ubiquitin,ligases
R13360	T20244	T20237	conj	ligases,IRAK1
R13361	T20245	T20244	punct	(,ligases
R13362	T20246	T20244	appos	TRAF2,ligases
R13363	T20247	T20246	punct	",",TRAF2
R13364	T20248	T20246	conj	TRAF6,TRAF2
R13365	T20249	T20244	punct	",",ligases
R13366	T20250	T20244	conj	cIAP1,ligases
R13367	T20251	T20250	punct	",",cIAP1
R13368	T20252	T20250	conj	cIAP2,cIAP1
R13369	T20253	T20227	punct	),IFNβ
R13370	T20254	T20204	prep	to,recruitment
R13371	T20255	T20256	det	the,receptor
R13372	T20256	T20254	pobj	receptor,to
R13373	T20257	T20202	punct	.,trigger
R13374	T20258	T20259	amod	K63-linked,polyubiquitination
R13375	T20259	T20268	nsubjpass	polyubiquitination,recognised
R13380	T20264	T20263	cc	and,RIP1
R13381	T20265	T20263	conj	IRAK1,RIP1
R13382	T20266	T20268	punct	",",recognised
R13383	T20267	T20268	auxpass	is,recognised
R13384	T20268	T20268	ROOT	recognised,recognised
R13385	T20269	T20268	agent	by,recognised
R13386	T20270	T20269	pobj	NEMO,by
R13387	T20271	T20270	cc	and,NEMO
R13388	T20272	T20270	conj	TAB,NEMO
R13389	T20273	T20268	advcl	proteins,recognised
R13390	T20274	T20268	punct	",",recognised
R13391	T20275	T20268	advcl	resulting,recognised
R13392	T20276	T20275	prep	in,resulting
R13393	T20277	T20278	det	the,recruitment
R13394	T20278	T20276	pobj	recruitment,in
R13395	T20279	T20278	cc	and,recruitment
R13396	T20280	T20278	conj	activation,recruitment
R13397	T20281	T20278	prep	of,recruitment
R13398	T20282	T20283	advmod	respectively,IKK2
R13399	T20283	T20275	npadvmod	IKK2,resulting
R13400	T20284	T20283	cc	and,IKK2
R13401	T20285	T20283	conj	TAK1,IKK2
R13402	T20286	T20268	punct	.,recognised
R13403	T20287	T20289	nummod	TAK1,phosphorylates
R13404	T20288	T20289	advmod	then,phosphorylates
R13405	T20289	T20289	ROOT	phosphorylates,phosphorylates
R13406	T20290	T20289	cc	and,phosphorylates
R13407	T20291	T20289	conj	activates,phosphorylates
R13408	T20292	T20291	dobj	IKK2,activates
R13409	T20293	T20292	punct	",",IKK2
R13410	T20294	T20300	dep	which,triggering
R13411	T20295	T20294	prep	in,which
R13412	T20296	T20295	pobj	turn,in
R13413	T20297	T20298	compound	phosphorylates,IκBα
R13414	T20298	T20295	pobj	IκBα,in
R13415	T20299	T20300	punct	",",triggering
R13416	T20300	T20291	advcl	triggering,activates
R13417	T20301	T20303	poss	its,ubiquitination
R13418	T20302	T20303	compound	K48-linked,ubiquitination
R13419	T20303	T20300	dobj	ubiquitination,triggering
R13420	T20304	T20303	cc	and,ubiquitination
R13421	T20305	T20306	amod	proteasomal,degradation
R13422	T20306	T20303	conj	degradation,ubiquitination
R13423	T20307	T20289	punct	.,phosphorylates
R13424	T20308	T20309	nsubj	This,allows
R13425	T20309	T20309	ROOT	allows,allows
R13426	T20310	T20309	dobj	NF-κB,allows
R13427	T20311	T20313	punct	(,shown
R13428	T20312	T20313	advmod	here,shown
R13429	T20313	T20310	parataxis	shown,NF-κB
R13430	T20314	T20313	prep	as,shown
R13431	T20315	T20316	det	a,heterodimer
R13432	T20316	T20314	pobj	heterodimer,as
R13433	T20317	T20316	prep	of,heterodimer
R13434	T20318	T20317	pobj	p65,of
R13435	T20319	T20318	cc	and,p65
R13436	T20320	T20318	conj	p50,p65
R13437	T20321	T20313	punct	),shown
R13438	T20322	T20310	advmod	to,NF-κB
R13439	T20323	T20322	pobj	translocate,to
R13440	T20324	T20323	prep	to,translocate
R13441	T20325	T20326	det	the,nucleus
R13442	T20326	T20324	pobj	nucleus,to
R13443	T20327	T20323	cc	and,translocate
R13444	T20328	T20323	conj	promote,translocate
R13445	T20329	T20330	compound	target,gene
R13446	T20330	T20331	compound	gene,expression
R13447	T20331	T20328	dobj	expression,promote
R13448	T20332	T20309	punct	.,allows
R13449	T20333	T20344	dep	TRAF1,regulate
R13450	T20334	T20333	punct	",",TRAF1
R13451	T20335	T20336	nsubj	which,has
R13452	T20336	T20333	relcl	has,TRAF1
R13453	T20337	T20340	det	no,activity
R13454	T20338	T20340	compound	ubiquitin,activity
R13455	T20339	T20340	compound	ligase,activity
R13456	T20340	T20336	dobj	activity,has
R13457	T20341	T20344	punct	",",regulate
R13458	T20342	T20344	aux	can,regulate
R13459	T20343	T20344	advmod	negatively,regulate
R13460	T20344	T20344	ROOT	regulate,regulate
R13461	T20345	T20346	amod	NF-κB,activation
R13462	T20346	T20344	dobj	activation,regulate
R13463	T20347	T20344	punct	",",regulate
R13464	T20348	T20349	advmod	most,probably
R13465	T20349	T20350	advmod	probably,by
R13466	T20350	T20344	prep	by,regulate
R13467	T20351	T20350	pcomp	competing,by
R13468	T20352	T20351	prep	with,competing
R13469	T20353	T20354	amod	other,TRAFs
R13470	T20354	T20352	pobj	TRAFs,with
R13471	T20355	T20344	punct	.,regulate
R13472	T20356	T20360	nsubj	A20,deubiquitinating
R13473	T20357	T20356	cc	and,A20
R13474	T20358	T20356	conj	CYLD,A20
R13475	T20359	T20360	aux	are,deubiquitinating
R13476	T20360	T20360	ROOT	deubiquitinating,deubiquitinating
R13477	T20361	T20360	dobj	enzymes,deubiquitinating
R13478	T20362	T20363	nsubj	that,control
R13479	T20363	T20361	relcl	control,enzymes
R13480	T20364	T20365	amod	NF-κB,activation
R13481	T20365	T20363	dobj	activation,control
R13482	T20366	T20363	prep	by,control
R13483	T20367	T20366	pcomp	targeting,by
R13484	T20368	T20370	amod	specific,proteins
R13485	T20369	T20370	amod	signalling,proteins
R13486	T20370	T20367	dobj	proteins,targeting
R13487	T20371	T20370	prep	including,proteins
R13488	T20372	T20371	pobj	RIP1,including
R13489	T20373	T20372	cc	and,RIP1
R13490	T20374	T20372	conj	TRAF6,RIP1
R13491	T20375	T20370	punct	",",proteins
R13492	T20376	T20380	prep	to,recruited
R13493	T20377	T20376	pobj	which,to
R13494	T20378	T20380	nsubjpass	they,recruited
R13495	T20379	T20380	auxpass	are,recruited
R13496	T20380	T20367	ccomp	recruited,targeting
R13497	T20381	T20380	advcl	using,recruited
R13498	T20382	T20385	amod	specific,proteins
R13499	T20383	T20385	amod	ubiquitin-binding,proteins
R13500	T20384	T20385	compound	adaptor,proteins
R13501	T20385	T20381	dobj	proteins,using
R13502	T20386	T20387	amod	such,as
R13503	T20387	T20385	prep	as,proteins
R13504	T20388	T20387	pobj	ABIN-1,as
R13505	T20389	T20388	cc	and,ABIN-1
R13506	T20390	T20388	conj	p62,ABIN-1
R13507	T20391	T20360	punct	.,deubiquitinating
R13508	T20392	T20394	nsubjpass	miR-146,thought
R13509	T20393	T20394	auxpass	is,thought
R13510	T20394	T20394	ROOT	thought,thought
R13511	T20395	T20397	aux	to,regulate
R13512	T20396	T20397	advmod	negatively,regulate
R13513	T20397	T20394	xcomp	regulate,thought
R13514	T20398	T20397	dobj	TLR,regulate
R13515	T20399	T20397	oprd	signalling,regulate
R13516	T20400	T20397	prep	by,regulate
R13517	T20401	T20400	pcomp	inhibiting,by
R13518	T20402	T20401	dobj	expression,inhibiting
R13519	T20403	T20402	prep	of,expression
R13520	T20404	T20403	pobj	IRAK1,of
R13521	T20405	T20404	cc	and,IRAK1
R13522	T20406	T20404	conj	TRAF6,IRAK1
R13523	T20407	T20394	punct	.,thought
R13524	T20408	T20415	advmod	Finally,inhibited
R13525	T20409	T20415	punct	",",inhibited
R13526	T20410	T20411	compound	TLR,signalling
R13527	T20411	T20415	nsubjpass	signalling,inhibited
R13528	T20412	T20415	aux	can,inhibited
R13529	T20413	T20415	advmod	also,inhibited
R13530	T20414	T20415	auxpass	be,inhibited
R13531	T20415	T20415	ROOT	inhibited,inhibited
R13532	T20416	T20415	agent	by,inhibited
R13533	T20417	T20419	det	the,protein
R13534	T20418	T20419	compound	transmembrane,protein
R13535	T20419	T20416	pobj	protein,by
R13536	T20420	T20419	appos	SIGIRR,protein
R13537	T20421	T20419	punct	",",protein
R13538	T20422	T20425	nsubjpass	which,proposed
R13539	T20423	T20425	aux	has,proposed
R13540	T20424	T20425	auxpass	been,proposed
R13541	T20425	T20419	relcl	proposed,protein
R13542	T20426	T20427	aux	to,compete
R13543	T20427	T20425	xcomp	compete,proposed
R13544	T20428	T20427	prep	with,compete
R13545	T20429	T20428	pobj	TLR4,with
R13546	T20430	T20429	prep	for,TLR4
R13547	T20431	T20430	amod	binding,for
R13548	T20432	T20431	prep	to,binding
R13549	T20433	T20432	pobj	IRAK1,to
R13550	T20434	T20433	cc	and,IRAK1
R13551	T20435	T20433	conj	TRAF6,IRAK1
R13552	T20436	T20415	punct	.,inhibited
R13553	T20437	T20438	det	The,expression
R13554	T20438	T20446	nsubj	expression,is
R13555	T20439	T20438	prep	of,expression
R13556	T20440	T20439	pobj	many,of
R13557	T20441	T20440	prep	of,many
R13558	T20442	T20445	det	these,molecules
R13559	T20443	T20445	amod	negative,molecules
R13560	T20444	T20445	amod	regulatory,molecules
R13561	T20445	T20441	pobj	molecules,of
R13562	T20446	T20446	ROOT	is,is
R13563	T20447	T20448	advmod	NF-κB,dependent
R13564	T20448	T20446	acomp	dependent,is
R13565	T20449	T20446	punct	",",is
R13566	T20450	T20446	advcl	implicating,is
R13567	T20451	T20450	dobj	them,implicating
R13568	T20452	T20450	prep	in,implicating
R13569	T20453	T20456	det	the,regulation
R13570	T20454	T20456	amod	negative,regulation
R13571	T20455	T20456	compound	feedback,regulation
R13572	T20456	T20452	pobj	regulation,in
R13573	T20457	T20456	prep	of,regulation
R13574	T20458	T20459	amod	NF-κB,activation
R13575	T20459	T20457	pobj	activation,of
R13576	T20460	T20446	punct	.,is
R13577	T20461	T20461	ROOT	ABIN,ABIN
R13578	T20462	T20464	punct	",",inhibitor
R13579	T20463	T20464	amod	A20-binding,inhibitor
R13580	T20464	T20461	appos	inhibitor,ABIN
R13581	T20465	T20464	prep	of,inhibitor
R13582	T20466	T20465	pobj	NF-κB,of
R13583	T20467	T20461	punct	;,ABIN
R13584	T20468	T20461	conj	cIAP,ABIN
R13585	T20469	T20468	punct	",",cIAP
R13586	T20470	T20471	amod	cellular,inhibitor
R13587	T20471	T20468	appos	inhibitor,cIAP
R13588	T20472	T20471	prep	of,inhibitor
R13589	T20473	T20472	pobj	apoptosis,of
R13590	T20474	T20468	punct	;,cIAP
R13591	T20475	T20468	conj	CYLD,cIAP
R13592	T20476	T20475	punct	",",CYLD
R13593	T20477	T20475	appos	cylindromatosis,CYLD
R13594	T20478	T20475	punct	;,CYLD
R13595	T20479	T20475	conj	IKK,CYLD
R13596	T20480	T20479	punct	",",IKK
R13597	T20481	T20482	compound	IκB,kinase
R13598	T20482	T20479	appos	kinase,IKK
R13599	T20483	T20479	punct	;,IKK
R13600	T20484	T20479	conj	IκB,IKK
R13601	T20485	T20484	punct	",",IκB
R13602	T20486	T20484	appos	inhibitor,IκB
R13603	T20487	T20486	prep	of,inhibitor
R13604	T20488	T20487	pobj	NF-κB,of
R13605	T20489	T20484	punct	;,IκB
R13606	T20490	T20484	conj	IRAK,IκB
R13607	T20491	T20490	punct	",",IRAK
R13608	T20492	T20493	amod	IL-1R-associated,kinase
R13609	T20493	T20490	appos	kinase,IRAK
R13610	T20494	T20490	punct	;,IRAK
R13611	T20495	T20490	conj	MyD88,IRAK
R13617	T20501	T20495	appos	gene,MyD88
R13618	T20502	T20501	nummod	88,gene
R13619	T20503	T20495	punct	;,MyD88
R13620	T20504	T20495	conj	NEMO,MyD88
R13621	T20505	T20504	punct	",",NEMO
R13622	T20506	T20508	nmod	NF-κB,modulator
R13623	T20507	T20508	amod	essential,modulator
R13624	T20508	T20504	appos	modulator,NEMO
R13625	T20509	T20504	punct	;,NEMO
R13626	T20510	T20504	conj	NF,NEMO
R13627	T20511	T20510	punct	",",NF
R13628	T20512	T20513	amod	nuclear,factor
R13629	T20513	T20510	appos	factor,NF
R13630	T20514	T20510	punct	;,NF
R13631	T20515	T20510	conj	RANK,NF
R13632	T20516	T20515	punct	",",RANK
R13633	T20517	T20518	compound	receptor,activator
R13634	T20518	T20515	appos	activator,RANK
R13635	T20519	T20518	prep	of,activator
R13636	T20520	T20519	pobj	NF-κB,of
R13637	T20521	T20461	punct	;,ABIN
R13638	T20522	T20461	conj	RIP1,ABIN
R13639	T20523	T20522	punct	",",RIP1
R13640	T20524	T20526	compound	receptor,protein
R13641	T20525	T20526	compound	interacting,protein
R13642	T20526	T20461	appos	protein,ABIN
R13643	T20527	T20526	nummod	1,protein
R13644	T20528	T20461	punct	;,ABIN
R13645	T20529	T20461	conj	SIGIRR,ABIN
R13646	T20530	T20529	punct	",",SIGIRR
R13647	T20531	T20532	amod	single-immunoglobulinIL-1,receptor-related
R13648	T20532	T20529	amod	receptor-related,SIGIRR
R13649	T20533	T20529	punct	;,SIGIRR
R13650	T20534	T20529	conj	TIR,SIGIRR
R13651	T20535	T20534	punct	",",TIR
R13652	T20536	T20537	compound	Toll-like,receptor/IL
R13653	T20537	T20534	conj	receptor/IL,TIR
R13654	T20538	T20539	nummod	-1,R
R13655	T20539	T20556	ccomp	R,factor
R13656	T20540	T20539	punct	;,R
R13657	T20541	T20544	npadvmod	TRAF,receptor-associated
R13658	T20542	T20544	punct	",",receptor-associated
R13659	T20543	T20544	nsubj	TNF,receptor-associated
R13660	T20544	T20556	ccomp	receptor-associated,factor
R13661	T20545	T20544	dobj	factor,receptor-associated
R13662	T20546	T20556	punct	;,factor
R13663	T20547	T20556	poss	TLR,factor
R13664	T20548	T20550	punct	",",receptor
R13665	T20549	T20550	amod	Toll-like,receptor
R13666	T20550	T20547	appos	receptor,TLR
R13667	T20551	T20547	punct	;,TLR
R13668	T20552	T20547	conj	TNF,TLR
R13669	T20553	T20552	punct	",",TNF
R13670	T20554	T20556	compound	tumour,factor
R13671	T20555	T20556	compound	necrosis,factor
R13672	T20556	T20556	ROOT	factor,factor
R13673	T20557	T20556	punct	.,factor
R13298	T20182	T20181	cc	and,signalling
R13299	T20183	T20184	amod	negative,regulators
R13376	T20260	T20259	prep	of,polyubiquitination
R13377	T20261	T20260	pobj	TRAFs,of
R13378	T20262	T20261	punct	",",TRAFs
R13379	T20263	T20261	conj	RIP1,TRAFs
R13612	T20496	T20495	punct	",",MyD88
R13613	T20497	T20498	amod	myeloid,differentiation
R13614	T20498	T20501	nmod	differentiation,gene
R13615	T20499	T20501	amod	primary,gene
R13616	T20500	T20501	compound	response,gene

DLUT931

Id	Subject	Object	Predicate	Lexical cue
T20674	247-252	Protein	denotes	MyD88
T20673	239-244	Protein	denotes	TRADD
T20672	191-237	Protein	denotes	TNF receptor 1-associated death domain protein
T20671	132-136	Protein	denotes	TLR4
T20670	122-126	Protein	denotes	RANK
T20669	116-120	Protein	denotes	CD40
T20668	386-391	Protein	denotes	cIAP2
T20667	379-384	Protein	denotes	cIAP1
T20666	372-377	Protein	denotes	TRAF6
T20665	365-370	Protein	denotes	TRAF2
T20664	334-339	Protein	denotes	IRAK4
T20663	327-332	Protein	denotes	IRAK1
T20662	321-325	Protein	denotes	RIP1
T20661	304-308	Protein	denotes	TRIF
T20660	109-114	Protein	denotes	TNFR1
T20726	1470-1477	Binding	denotes	binding
T20725	1448-1455	Binding	denotes	compete
T20724	1296-1306	Negative_regulation	denotes	inhibiting
T20723	1307-1317	Gene_expression	denotes	expression
T20722	1152-1161	Binding	denotes	recruited
T20721	766-777	Binding	denotes	heterodimer
T20720	640-654	Phosphorylation	denotes	phosphorylates
T20719	610-619	Positive_regulation	denotes	activates
T20718	539-549	Positive_regulation	denotes	activation
T20717	523-534	Binding	denotes	recruitment
T20716	421-439	Ubiquitination	denotes	polyubiquitination
T20715	2161-2183	Protein	denotes	tumour necrosis factor
T20714	2156-2159	Protein	denotes	TNF
T20713	2018-2060	Protein	denotes	single-immunoglobulinIL-1 receptor-related
T20712	2010-2016	Protein	denotes	SIGIRR
T20711	1978-2008	Protein	denotes	receptor interacting protein 1
T20710	1972-1976	Protein	denotes	RIP1
T20709	1943-1970	Protein	denotes	receptor activator of NF-κB
T20708	1937-1941	Protein	denotes	RANK
T20707	1890-1915	Protein	denotes	NF-κB essential modulator
T20706	1884-1888	Protein	denotes	NEMO
T20705	1834-1882	Protein	denotes	myeloid differentiation primary response gene 88
T20704	1827-1832	Protein	denotes	MyD88
T20703	1737-1752	Protein	denotes	cylindromatosis
T20702	1731-1735	Protein	denotes	CYLD
T20701	1660-1690	Protein	denotes	A20-binding inhibitor of NF-κB
T20700	1654-1658	Protein	denotes	ABIN
T20699	1491-1496	Protein	denotes	TRAF6
T20698	1481-1486	Protein	denotes	IRAK1
T20697	1461-1465	Protein	denotes	TLR4
T20696	1413-1419	Protein	denotes	SIGIRR
T20695	1331-1336	Protein	denotes	TRAF6
T20694	1321-1326	Protein	denotes	IRAK1
T20693	1231-1234	Protein	denotes	p62
T20692	1220-1226	Protein	denotes	ABIN-1
T20691	1127-1132	Protein	denotes	TRAF6
T20690	1118-1122	Protein	denotes	RIP1
T20689	1002-1006	Protein	denotes	CYLD
T20688	994-997	Protein	denotes	A20
T20687	860-865	Protein	denotes	TRAF1
T20686	789-792	Protein	denotes	p50
T20685	781-784	Protein	denotes	p65
T20684	655-659	Protein	denotes	IκBα
T20683	620-624	Protein	denotes	IKK2
T20682	581-585	Protein	denotes	TAK1
T20681	575-579	Protein	denotes	TAK1
T20680	566-570	Protein	denotes	IKK2
T20679	483-487	Protein	denotes	NEMO
T20678	459-464	Protein	denotes	IRAK1
T20677	450-454	Protein	denotes	RIP1
T20676	259-302	Protein	denotes	TIR domain-containing adaptor-inducing IFNβ
T20675	254-257	Protein	denotes	MAL
R13713	T20677	T20716	themeOf	RIP1,polyubiquitination
R13714	T20678	T20716	themeOf	IRAK1,polyubiquitination
R13715	T20680	T20717	themeOf	IKK2,recruitment
R13716	T20681	T20717	themeOf	TAK1,recruitment
R13717	T20682	T20719	causeOf	TAK1,activates
R13718	T20683	T20719	themeOf	IKK2,activates
R13719	T20683	T20720	themeOf	IKK2,phosphorylates
R13720	T20684	T20720	themeOf	IκBα,phosphorylates
R13721	T20685	T20721	themeOf	p65,heterodimer
R13722	T20686	T20721	themeOf	p50,heterodimer
R13723	T20690	T20722	themeOf	RIP1,recruited
R13724	T20690	T20722	themeOf	RIP1,recruited
R13725	T20691	T20722	themeOf	TRAF6,recruited
R13726	T20692	T20722	themeOf	ABIN-1,recruited
R13727	T20692	T20722	themeOf	ABIN-1,recruited
R13728	T20693	T20722	themeOf	p62,recruited
R13729	T20694	T20723	themeOf	IRAK1,expression
R13730	T20695	T20723	themeOf	TRAF6,expression
R13731	T20696	T20725	themeOf	SIGIRR,compete
R13732	T20697	T20725	themeOf	TLR4,compete
R13733	T20698	T20726	themeOf	IRAK1,binding
R13734	T20699	T20726	themeOf	TRAF6,binding
R13735	T20717	T20718	themeOf	recruitment,activation
R13736	T20723	T20724	themeOf	expression,inhibiting
R13737	T20723	T20724	themeOf	expression,inhibiting

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T20589	1759-1769	http://www.uniprot.org/uniprot/Q60680-2	denotes	IκB kinase
T20588	1759-1769	http://www.uniprot.org/uniprot/O15111	denotes	IκB kinase
T20587	1220-1226	http://www.uniprot.org/uniprot/Q15025	denotes	ABIN-1
T20586	1660-1663	http://www.uniprot.org/uniprot/P21580	denotes	A20
T20585	994-997	http://www.uniprot.org/uniprot/P21580	denotes	A20
T20584	789-792	http://www.uniprot.org/uniprot/P19838	denotes	p50
T20583	781-784	http://www.uniprot.org/uniprot/P21579	denotes	p65
T20582	781-784	http://www.uniprot.org/uniprot/Q04206	denotes	p65
T20581	655-659	http://www.uniprot.org/uniprot/P25963	denotes	IκBα
T20580	620-624	http://www.uniprot.org/uniprot/O14920	denotes	IKK2
T20579	566-570	http://www.uniprot.org/uniprot/O14920	denotes	IKK2
T20578	1884-1888	http://www.uniprot.org/uniprot/Q9Y6K9	denotes	NEMO
T20577	483-487	http://www.uniprot.org/uniprot/Q9Y6K9	denotes	NEMO
T20576	379-384	http://www.uniprot.org/uniprot/Q13490	denotes	cIAP1
T20575	1491-1496	http://www.uniprot.org/uniprot/Q9Y4K3	denotes	TRAF6
T20574	1331-1336	http://www.uniprot.org/uniprot/Q9Y4K3	denotes	TRAF6
T20573	1127-1132	http://www.uniprot.org/uniprot/Q9Y4K3	denotes	TRAF6
T20572	372-377	http://www.uniprot.org/uniprot/Q9Y4K3	denotes	TRAF6
T20571	365-370	http://www.uniprot.org/uniprot/Q12933	denotes	TRAF2
T20570	1972-1976	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T20569	1118-1122	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T20568	450-454	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T20567	321-325	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T20566	254-257	http://www.uniprot.org/uniprot/P01732	denotes	MAL
T20565	1827-1832	http://www.uniprot.org/uniprot/Q99836	denotes	MyD88
T20564	247-252	http://www.uniprot.org/uniprot/Q99836	denotes	MyD88
T20563	2156-2159	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T20562	2099-2102	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T20561	191-194	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T20560	1461-1465	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T20559	132-136	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T20558	116-120	http://www.uniprot.org/uniprot/P25942	denotes	CD40

bionlp-st-ge-2016-test-proteins

Id	Subject	Object	Predicate	Lexical cue
T19639	2161-2183	Protein	denotes	tumour necrosis factor
T19638	2156-2159	Protein	denotes	TNF
T19637	2018-2060	Protein	denotes	single-immunoglobulinIL-1 receptor-related
T19636	2010-2016	Protein	denotes	SIGIRR
T19635	1978-2008	Protein	denotes	receptor interacting protein 1
T19634	1972-1976	Protein	denotes	RIP1
T19633	1943-1970	Protein	denotes	receptor activator of NF-κB
T19632	1937-1941	Protein	denotes	RANK
T19631	1890-1915	Protein	denotes	NF-κB essential modulator
T19630	1884-1888	Protein	denotes	NEMO
T19629	1834-1882	Protein	denotes	myeloid differentiation primary response gene 88
T19628	1827-1832	Protein	denotes	MyD88
T19627	1737-1752	Protein	denotes	cylindromatosis
T19626	1731-1735	Protein	denotes	CYLD
T19625	1660-1690	Protein	denotes	A20-binding inhibitor of NF-κB
T19624	1654-1658	Protein	denotes	ABIN
T19623	1491-1496	Protein	denotes	TRAF6
T19622	1481-1486	Protein	denotes	IRAK1
T19621	1461-1465	Protein	denotes	TLR4
T19620	1413-1419	Protein	denotes	SIGIRR
T19619	1331-1336	Protein	denotes	TRAF6
T19618	1321-1326	Protein	denotes	IRAK1
T19617	1231-1234	Protein	denotes	p62
T19616	1220-1226	Protein	denotes	ABIN-1
T19615	1127-1132	Protein	denotes	TRAF6
T19614	1118-1122	Protein	denotes	RIP1
T19613	1002-1006	Protein	denotes	CYLD
T19612	994-997	Protein	denotes	A20
T19611	860-865	Protein	denotes	TRAF1
T19610	789-792	Protein	denotes	p50
T19609	781-784	Protein	denotes	p65
T19608	655-659	Protein	denotes	IκBα
T19607	620-624	Protein	denotes	IKK2
T19606	581-585	Protein	denotes	TAK1
T19605	575-579	Protein	denotes	TAK1
T19604	566-570	Protein	denotes	IKK2
T19603	483-487	Protein	denotes	NEMO
T19602	459-464	Protein	denotes	IRAK1
T19601	450-454	Protein	denotes	RIP1
T19600	386-391	Protein	denotes	cIAP2
T19599	379-384	Protein	denotes	cIAP1
T19598	372-377	Protein	denotes	TRAF6
T19597	365-370	Protein	denotes	TRAF2
T19596	334-339	Protein	denotes	IRAK4
T19595	327-332	Protein	denotes	IRAK1
T19594	321-325	Protein	denotes	RIP1
T19593	304-308	Protein	denotes	TRIF
T19592	259-302	Protein	denotes	TIR domain-containing adaptor-inducing IFNβ
T19591	254-257	Protein	denotes	MAL
T19590	247-252	Protein	denotes	MyD88
T19589	239-244	Protein	denotes	TRADD
T19588	191-237	Protein	denotes	TNF receptor 1-associated death domain protein
T19587	132-136	Protein	denotes	TLR4
T19586	122-126	Protein	denotes	RANK
T19585	116-120	Protein	denotes	CD40
T19584	109-114	Protein	denotes	TNFR1

bionlp-st-ge-2016-coref

Id	Subject	Object	Predicate	Lexical cue
T19583	1413-1419	Antecedent	denotes	SIGIRR
T19582	1421-1426	Anaphor	denotes	which
T19581	1231-1234	Antecedent	denotes	p62
T19580	1220-1226	Antecedent	denotes	ABIN-1
T19579	1195-1211	Anaphor	denotes	adaptor proteins
T19578	1002-1006	Antecedent	denotes	CYLD
T19577	994-997	Antecedent	denotes	A20
T19576	1143-1147	Anaphor	denotes	they
T19575	655-659	Antecedent	denotes	IκBα
T19574	672-675	Anaphor	denotes	its
T19573	132-136	Antecedent	denotes	TLR4
T19572	122-126	Antecedent	denotes	RANK
T19571	116-120	Antecedent	denotes	CD40
T19570	109-114	Antecedent	denotes	TNFR1
T19569	82-100	Anaphor	denotes	membrane receptors
R12918	T19569	T19570	boundBy	membrane receptors,TNFR1
R12919	T19569	T19571	boundBy	membrane receptors,CD40
R12920	T19569	T19572	boundBy	membrane receptors,RANK
R12921	T19569	T19573	boundBy	membrane receptors,TLR4
R12922	T19574	T19575	boundBy	its,IκBα
R12923	T19576	T19577	boundBy	they,A20
R12924	T19576	T19578	boundBy	they,CYLD
R12925	T19579	T19580	boundBy	adaptor proteins,ABIN-1
R12926	T19579	T19581	boundBy	adaptor proteins,p62
R12927	T19582	T19583	boundBy	which,SIGIRR

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T20005	2177-2183	NN	denotes	factor
T20004	2168-2176	NN	denotes	necrosis
T20003	2161-2167	NN	denotes	tumour
T20002	2159-2160	-COMMA-	denotes	,
T20001	2156-2159	NN	denotes	TNF
T20000	2154-2155	-COLON-	denotes	;
T19999	2146-2154	NN	denotes	receptor
T19998	2136-2145	JJ	denotes	Toll-like
T19997	2134-2135	-COMMA-	denotes	,
T19996	2131-2134	NN	denotes	TLR
T19995	2129-2130	-COLON-	denotes	;
T19994	2123-2129	NN	denotes	factor
T19993	2103-2122	JJ	denotes	receptor-associated
T19992	2099-2102	NN	denotes	TNF
T19991	2097-2098	-COMMA-	denotes	,
T19990	2093-2097	NN	denotes	TRAF
T19989	2091-2092	-COLON-	denotes	;
T19988	2077-2091	NN	denotes	receptor/IL-1R
T19987	2067-2076	JJ	denotes	Toll-like
T19986	2065-2066	-COMMA-	denotes	,
T19985	2062-2065	NN	denotes	TIR
T19984	2060-2061	-COLON-	denotes	;
T19983	2044-2060	JJ	denotes	receptor-related
T19982	2018-2043	NN	denotes	single-immunoglobulinIL-1
T19981	2016-2017	-COMMA-	denotes	,
T19980	2010-2016	NN	denotes	SIGIRR
T19979	2008-2009	-COLON-	denotes	;
T19978	2007-2008	CD	denotes	1
T19977	1999-2006	NN	denotes	protein
T19976	1987-1998	VB	denotes	interacting
T19975	1978-1986	NN	denotes	receptor
T19974	1976-1977	-COMMA-	denotes	,
T19973	1972-1976	NN	denotes	RIP1
T19972	1970-1971	-COLON-	denotes	;
T19971	1965-1970	NN	denotes	NF-κB
T19970	1962-1964	IN	denotes	of
T19969	1952-1961	NN	denotes	activator
T19968	1943-1951	NN	denotes	receptor
T19967	1941-1942	-COMMA-	denotes	,
T19966	1937-1941	NN	denotes	RANK
T19965	1935-1936	-COLON-	denotes	;
T19964	1929-1935	NN	denotes	factor
T19963	1921-1928	JJ	denotes	nuclear
T19962	1919-1920	-COMMA-	denotes	,
T19961	1917-1919	NN	denotes	NF
T19960	1915-1916	-COLON-	denotes	;
T19959	1906-1915	NN	denotes	modulator
T19958	1896-1905	JJ	denotes	essential
T19957	1890-1895	NN	denotes	NF-κB
T19956	1888-1889	-COMMA-	denotes	,
T19955	1884-1888	NN	denotes	NEMO
T19954	1882-1883	-COLON-	denotes	;
T19953	1880-1882	CD	denotes	88
T19952	1875-1879	NN	denotes	gene
T19951	1866-1874	NN	denotes	response
T19950	1858-1865	JJ	denotes	primary
T19949	1842-1857	NN	denotes	differentiation
T19948	1834-1841	JJ	denotes	myeloid
T19947	1832-1833	-COMMA-	denotes	,
T19946	1827-1832	NN	denotes	MyD88
T19945	1825-1826	-COLON-	denotes	;
T19944	1819-1825	NN	denotes	kinase
T19943	1802-1818	JJ	denotes	IL-1R-associated
T19942	1800-1801	-COMMA-	denotes	,
T19941	1796-1800	NN	denotes	IRAK
T19940	1794-1795	-COLON-	denotes	;
T19939	1789-1794	NN	denotes	NF-κB
T19938	1786-1788	IN	denotes	of
T19937	1776-1785	NN	denotes	inhibitor
T19936	1774-1775	-COMMA-	denotes	,
T19935	1771-1774	NN	denotes	IκB
T19934	1769-1770	-COLON-	denotes	;
T19933	1763-1769	NN	denotes	kinase
T19932	1759-1762	NN	denotes	IκB
T19931	1757-1758	-COMMA-	denotes	,
T19930	1754-1757	NN	denotes	IKK
T19929	1752-1753	-COLON-	denotes	;
T19928	1737-1752	NN	denotes	cylindromatosis
T19927	1735-1736	-COMMA-	denotes	,
T19926	1731-1735	NN	denotes	CYLD
T19925	1729-1730	-COLON-	denotes	;
T19924	1720-1729	NN	denotes	apoptosis
T19923	1717-1719	IN	denotes	of
T19922	1707-1716	NN	denotes	inhibitor
T19921	1698-1706	JJ	denotes	cellular
T19920	1696-1697	-COMMA-	denotes	,
T19919	1692-1696	NN	denotes	cIAP
T19918	1690-1691	-COLON-	denotes	;
T19917	1685-1690	NN	denotes	NF-κB
T19916	1682-1684	IN	denotes	of
T19915	1672-1681	NN	denotes	inhibitor
T19914	1660-1671	JJ	denotes	A20-binding
T19913	1658-1659	-COMMA-	denotes	,
T19912	1654-1658	NN	denotes	ABIN
T19911	1642-1652	NN	denotes	activation
T19910	1636-1641	NN	denotes	NF-κB
T19909	1633-1635	IN	denotes	of
T19908	1622-1632	NN	denotes	regulation
T19907	1613-1621	NN	denotes	feedback
T19906	1604-1612	JJ	denotes	negative
T19905	1600-1603	DT	denotes	the
T19904	1597-1599	IN	denotes	in
T19903	1592-1596	PRP	denotes	them
T19902	1580-1591	VB	denotes	implicating
T19901	1578-1579	-COMMA-	denotes	,
T19900	1569-1578	JJ	denotes	dependent
T19899	1563-1568	NN	denotes	NF-κB
T19898	1560-1562	VB	denotes	is
T19897	1550-1559	NN	denotes	molecules
T19896	1539-1549	JJ	denotes	regulatory
T19895	1530-1538	JJ	denotes	negative
T19894	1524-1529	DT	denotes	these
T19893	1521-1523	IN	denotes	of
T19892	1516-1520	JJ	denotes	many
T19891	1513-1515	IN	denotes	of
T19890	1502-1512	NN	denotes	expression
T19889	1498-1501	DT	denotes	The
T19888	1491-1496	NN	denotes	TRAF6
T19887	1487-1490	CC	denotes	and
T19886	1481-1486	NN	denotes	IRAK1
T19885	1478-1480	TO	denotes	to
T19884	1470-1477	VB	denotes	binding
T19883	1466-1469	IN	denotes	for
T19882	1461-1465	NN	denotes	TLR4
T19881	1456-1460	IN	denotes	with
T19880	1448-1455	VB	denotes	compete
T19879	1445-1447	TO	denotes	to
T19878	1436-1444	VB	denotes	proposed
T19877	1431-1435	VB	denotes	been
T19876	1427-1430	VB	denotes	has
T19875	1421-1426	WDT	denotes	which
T19874	1419-1420	-COMMA-	denotes	,
T19873	1413-1419	NN	denotes	SIGIRR
T19872	1405-1412	NN	denotes	protein
T19871	1391-1404	JJ	denotes	transmembrane
T19870	1387-1390	DT	denotes	the
T19869	1384-1386	IN	denotes	by
T19868	1374-1383	VB	denotes	inhibited
T19867	1371-1373	VB	denotes	be
T19866	1366-1370	RB	denotes	also
T19865	1362-1365	MD	denotes	can
T19864	1351-1361	NN	denotes	signalling
T19863	1347-1350	NN	denotes	TLR
T19862	1345-1346	-COMMA-	denotes	,
T19861	1338-1345	RB	denotes	Finally
T19860	1331-1336	NN	denotes	TRAF6
T19859	1327-1330	CC	denotes	and
T19858	1321-1326	NN	denotes	IRAK1
T19857	1318-1320	IN	denotes	of
T19856	1307-1317	NN	denotes	expression
T19855	1296-1306	VB	denotes	inhibiting
T19854	1293-1295	IN	denotes	by
T19853	1282-1292	NN	denotes	signalling
T19852	1278-1281	NN	denotes	TLR
T19851	1269-1277	VB	denotes	regulate
T19850	1258-1268	RB	denotes	negatively
T19849	1255-1257	TO	denotes	to
T19848	1247-1254	VB	denotes	thought
T19847	1244-1246	VB	denotes	is
T19846	1236-1243	NN	denotes	miR-146
T19845	1231-1235	NN	denotes	p62.
T19844	1227-1230	CC	denotes	and
T19843	1220-1226	NN	denotes	ABIN-1
T19842	1217-1219	IN	denotes	as
T19841	1212-1216	JJ	denotes	such
T19840	1203-1211	NN	denotes	proteins
T19839	1195-1202	NN	denotes	adaptor
T19838	1177-1194	JJ	denotes	ubiquitin-binding
T19837	1168-1176	JJ	denotes	specific
T19836	1162-1167	VB	denotes	using
T19835	1152-1161	VB	denotes	recruited
T19834	1148-1151	VB	denotes	are
T19833	1143-1147	PRP	denotes	they
T19832	1137-1142	WDT	denotes	which
T19831	1134-1136	TO	denotes	to
T19830	1132-1133	-COMMA-	denotes	,
T19829	1127-1132	NN	denotes	TRAF6
T19828	1123-1126	CC	denotes	and
T19827	1118-1122	NN	denotes	RIP1
T19826	1108-1117	VB	denotes	including
T19825	1099-1107	NN	denotes	proteins
T19824	1088-1098	NN	denotes	signalling
T19823	1079-1087	JJ	denotes	specific
T19822	1069-1078	VB	denotes	targeting
T19821	1066-1068	IN	denotes	by
T19820	1055-1065	NN	denotes	activation
T19819	1049-1054	NN	denotes	NF-κB
T19783	816-823	NN	denotes	nucleus
T19782	812-815	DT	denotes	the
T19781	809-811	TO	denotes	to
T19780	797-808	VB	denotes	translocate
T19779	794-796	TO	denotes	to
T19778	792-793	-RRB-	denotes	)
T19777	789-792	NN	denotes	p50
T19776	785-788	CC	denotes	and
T19775	781-784	NN	denotes	p65
T19774	778-780	IN	denotes	of
T19773	766-777	NN	denotes	heterodimer
T19772	764-765	DT	denotes	a
T19771	761-763	IN	denotes	as
T19770	755-760	VB	denotes	shown
T19769	750-754	RB	denotes	here
T19768	749-750	-LRB-	denotes	(
T19767	743-748	NN	denotes	NF-κB
T19766	736-742	VB	denotes	allows
T19765	731-735	DT	denotes	This
T19764	718-729	NN	denotes	degradation
T19763	706-717	JJ	denotes	proteasomal
T19762	702-705	CC	denotes	and
T19761	687-701	NN	denotes	ubiquitination
T19760	676-686	JJ	denotes	K48-linked
T19759	672-675	PRP-DOLLAR-	denotes	its
T19758	661-671	VB	denotes	triggering
T19757	659-660	-COMMA-	denotes	,
T19756	655-659	NN	denotes	IκBα
T19755	640-654	VB	denotes	phosphorylates
T19754	635-639	NN	denotes	turn
T19753	632-634	IN	denotes	in
T19752	626-631	WDT	denotes	which
T19751	624-625	-COMMA-	denotes	,
T19750	620-624	NN	denotes	IKK2
T19749	610-619	VB	denotes	activates
T19748	606-609	CC	denotes	and
T19747	591-605	VB	denotes	phosphorylates
T19746	586-590	RB	denotes	then
T19745	581-585	NN	denotes	TAK1
T19744	575-579	NN	denotes	TAK1
T19743	571-574	CC	denotes	and
T19742	566-570	NN	denotes	IKK2
T19741	553-565	RB	denotes	respectively
T19740	550-552	IN	denotes	of
T19739	539-549	NN	denotes	activation
T19738	535-538	CC	denotes	and
T19737	523-534	NN	denotes	recruitment
T19736	519-522	DT	denotes	the
T19735	516-518	IN	denotes	in
T19734	506-515	VB	denotes	resulting
T19733	504-505	-COMMA-	denotes	,
T19732	496-504	NN	denotes	proteins
T19731	492-495	NN	denotes	TAB
T19730	488-491	CC	denotes	and
T19729	483-487	NN	denotes	NEMO
T19728	480-482	IN	denotes	by
T19727	469-479	VB	denotes	recognised
T19726	466-468	VB	denotes	is
T19725	464-465	-COMMA-	denotes	,
T19724	459-464	NN	denotes	IRAK1
T19723	455-458	CC	denotes	and
T19722	450-454	NN	denotes	RIP1
T19721	448-449	-COMMA-	denotes	,
T19720	443-448	NN	denotes	TRAFs
T19719	440-442	IN	denotes	of
T19718	421-439	NN	denotes	polyubiquitination
T19717	410-420	JJ	denotes	K63-linked
T19716	400-408	NN	denotes	receptor
T19715	396-399	DT	denotes	the
T19714	393-395	TO	denotes	to
T19713	391-392	-RRB-	denotes	)
T19712	386-391	NN	denotes	cIAP2
T19711	384-385	-COMMA-	denotes	,
T19710	379-384	NN	denotes	cIAP1
T19709	377-378	-COMMA-	denotes	,
T19708	372-377	NN	denotes	TRAF6
T19707	370-371	-COMMA-	denotes	,
T19706	365-370	NN	denotes	TRAF2
T19705	364-365	-LRB-	denotes	(
T19704	356-363	NN	denotes	ligases
T19703	346-355	NN	denotes	ubiquitin
T19702	342-345	CC	denotes	and
T19701	340-341	-COMMA-	denotes	,
T19700	339-340	-RRB-	denotes	)
T19699	334-339	NN	denotes	IRAK4
T19698	332-333	-COMMA-	denotes	,
T19697	327-332	NN	denotes	IRAK1
T19696	325-326	-COMMA-	denotes	,
T19695	321-325	NN	denotes	RIP1
T19694	320-321	-LRB-	denotes	(
T19693	312-319	NN	denotes	kinases
T19692	310-311	-COMMA-	denotes	,
T19691	309-310	-RRB-	denotes	)
T19690	308-309	-RRB-	denotes	)
T19689	304-308	NN	denotes	TRIF
T19688	303-304	-LRB-	denotes	(
T19687	298-302	NN	denotes	IFNβ
T19686	281-297	JJ	denotes	adaptor-inducing
T19685	263-280	JJ	denotes	domain-containing
T19684	259-262	NN	denotes	TIR
T19683	257-258	-COMMA-	denotes	,
T19682	254-257	NNP	denotes	MAL
T19681	252-253	-COMMA-	denotes	,
T19680	247-252	NN	denotes	MyD88
T19679	245-246	-COMMA-	denotes	,
T19678	244-245	-RRB-	denotes	)
T19677	239-244	NN	denotes	TRADD
T19676	238-239	-LRB-	denotes	(
T19675	230-237	NN	denotes	protein
T19674	223-229	NN	denotes	domain
T19673	217-222	NN	denotes	death
T19672	204-216	JJ	denotes	1-associated
T19671	195-203	NN	denotes	receptor
T19670	191-194	NN	denotes	TNF
T19669	190-191	-LRB-	denotes	(
T19668	181-189	NN	denotes	proteins
T19667	173-180	NN	denotes	adaptor
T19666	164-172	JJ	denotes	specific
T19665	161-163	IN	denotes	of
T19664	149-160	NN	denotes	recruitment
T19663	145-148	DT	denotes	the
T19662	137-144	VB	denotes	trigger
T19661	132-136	NN	denotes	TLR4
T19660	128-131	CC	denotes	and
T19659	126-127	-COMMA-	denotes	,
T19658	122-126	NN	denotes	RANK
T19657	120-121	-COMMA-	denotes	,
T19656	116-120	NN	denotes	CD40
T19655	114-115	-COMMA-	denotes	,
T19654	109-114	NN	denotes	TNFR1
T19653	106-108	IN	denotes	as
T19652	101-105	JJ	denotes	such
T19651	91-100	NN	denotes	receptors
T19650	82-90	NN	denotes	membrane
T19649	73-81	JJ	denotes	specific
T19648	70-72	IN	denotes	of
T19647	59-69	NN	denotes	engagement
T19646	52-58	NN	denotes	Ligand
T19645	40-50	NN	denotes	regulators
T19644	31-39	JJ	denotes	negative
T19643	27-30	CC	denotes	and
T19642	16-26	NN	denotes	signalling
T19641	10-15	NN	denotes	NF-κB
T19640	0-9	JJ	denotes	Canonical
T19818	1041-1048	VB	denotes	control
T19817	1036-1040	WDT	denotes	that
T19816	1028-1035	NN	denotes	enzymes
T19815	1011-1027	VB	denotes	deubiquitinating
T19814	1007-1010	VB	denotes	are
T19813	1002-1006	NN	denotes	CYLD
T19812	998-1001	CC	denotes	and
T19811	994-997	NN	denotes	A20
T19810	987-992	NN	denotes	TRAFs
T19809	981-986	JJ	denotes	other
T19808	976-980	IN	denotes	with
T19807	966-975	VB	denotes	competing
T19806	963-965	IN	denotes	by
T19805	954-962	RB	denotes	probably
T19804	949-953	RB	denotes	most
T19803	947-948	-COMMA-	denotes	,
T19802	937-947	NN	denotes	activation
T19801	931-936	NN	denotes	NF-κB
T19800	922-930	VB	denotes	regulate
T19799	911-921	RB	denotes	negatively
T19798	907-910	MD	denotes	can
T19797	905-906	-COMMA-	denotes	,
T19796	897-905	NN	denotes	activity
T19795	890-896	NN	denotes	ligase
T19794	880-889	NN	denotes	ubiquitin
T19793	877-879	DT	denotes	no
T19792	873-876	VB	denotes	has
T19791	867-872	WDT	denotes	which
T19790	865-866	-COMMA-	denotes	,
T19789	860-865	NN	denotes	TRAF1
T19788	848-858	NN	denotes	expression
T19787	843-847	NN	denotes	gene
T19786	836-842	NN	denotes	target
T19785	828-835	VB	denotes	promote
T19784	824-827	CC	denotes	and
R13240	T19944	T19943	arg1Of	kinase,IL-1R-associated
R13241	T19946	T19947	arg1Of	MyD88,","
R12928	T19642	T19640	arg1Of	signalling,Canonical
R12929	T19642	T19641	arg1Of	signalling,NF-κB
R12930	T19642	T19643	arg1Of	signalling,and
R12931	T19645	T19643	arg2Of	regulators,and
R12932	T19645	T19644	arg1Of	regulators,negative
R12933	T19647	T19646	arg1Of	engagement,Ligand
R12934	T19647	T19648	arg1Of	engagement,of
R12935	T19647	T19662	arg1Of	engagement,trigger
R12936	T19651	T19648	arg2Of	receptors,of
R12937	T19651	T19649	arg1Of	receptors,specific
R12938	T19651	T19650	arg1Of	receptors,membrane
R12939	T19651	T19653	arg1Of	receptors,as
R12940	T19653	T19652	arg1Of	as,such
R12941	T19654	T19655	arg1Of	TNFR1,","
R12942	T19655	T19657	arg1Of	",",","
R12943	T19656	T19655	arg2Of	CD40,","
R12944	T19657	T19660	arg1Of	",",and
R12945	T19658	T19657	arg2Of	RANK,","
R12946	T19660	T19653	arg2Of	and,as
R12947	T19660	T19659	arg1Of	and,","
R12948	T19661	T19660	arg2Of	TLR4,and
R12949	T19664	T19662	arg2Of	recruitment,trigger
R12950	T19664	T19663	arg1Of	recruitment,the
R12951	T19664	T19665	arg1Of	recruitment,of
R12952	T19668	T19666	arg1Of	proteins,specific
R12953	T19668	T19667	arg1Of	proteins,adaptor
R12954	T19668	T19669	arg1Of	proteins,(
R12955	T19668	T19692	arg1Of	proteins,","
R12956	T19675	T19670	arg1Of	protein,TNF
R12957	T19675	T19671	arg1Of	protein,receptor
R12958	T19675	T19672	arg1Of	protein,1-associated
R12959	T19675	T19673	arg1Of	protein,death
R12960	T19675	T19674	arg1Of	protein,domain
R12961	T19675	T19676	arg1Of	protein,(
R12962	T19675	T19679	arg1Of	protein,","
R12963	T19677	T19676	arg2Of	TRADD,(
R12964	T19678	T19676	arg3Of	),(
R12965	T19679	T19681	arg1Of	",",","
R12966	T19680	T19679	arg2Of	MyD88,","
R12967	T19681	T19683	arg1Of	",",","
R12968	T19682	T19681	arg2Of	MAL,","
R12969	T19683	T19669	arg2Of	",",(
R12970	T19687	T19683	arg2Of	IFNβ,","
R12971	T19687	T19684	arg1Of	IFNβ,TIR
R12972	T19687	T19685	arg1Of	IFNβ,domain-containing
R12973	T19687	T19686	arg1Of	IFNβ,adaptor-inducing
R12974	T19687	T19688	arg1Of	IFNβ,(
R12975	T19689	T19688	arg2Of	TRIF,(
R12976	T19690	T19688	arg3Of	),(
R12977	T19691	T19669	arg3Of	),(
R12978	T19692	T19665	arg2Of	",",of
R12979	T19692	T19714	arg1Of	",",to
R12980	T19693	T19694	arg1Of	kinases,(
R12981	T19693	T19702	arg1Of	kinases,and
R12982	T19695	T19694	arg2Of	RIP1,(
R12983	T19695	T19696	arg1Of	RIP1,","
R12984	T19695	T19698	arg1Of	RIP1,","
R12985	T19697	T19696	arg2Of	IRAK1,","
R12986	T19699	T19698	arg2Of	IRAK4,","
R12987	T19700	T19694	arg3Of	),(
R12988	T19702	T19692	arg2Of	and,","
R12989	T19702	T19701	arg1Of	and,","
R12990	T19704	T19702	arg2Of	ligases,and
R12991	T19704	T19703	arg1Of	ligases,ubiquitin
R12992	T19704	T19705	arg1Of	ligases,(
R12993	T19706	T19707	arg1Of	TRAF2,","
R12994	T19707	T19709	arg1Of	",",","
R12995	T19708	T19707	arg2Of	TRAF6,","
R12996	T19709	T19705	arg2Of	",",(
R12997	T19709	T19711	arg1Of	",",","
R12998	T19710	T19709	arg2Of	cIAP1,","
R12999	T19712	T19711	arg2Of	cIAP2,","
R13000	T19713	T19705	arg3Of	),(
R13001	T19716	T19714	arg2Of	receptor,to
R13002	T19716	T19715	arg1Of	receptor,the
R13003	T19718	T19717	arg1Of	polyubiquitination,K63-linked
R13004	T19718	T19719	arg1Of	polyubiquitination,of
R13005	T19718	T19726	arg1Of	polyubiquitination,is
R13006	T19718	T19727	arg2Of	polyubiquitination,recognised
R13007	T19720	T19719	arg2Of	TRAFs,of
R13008	T19720	T19721	arg1Of	TRAFs,","
R13009	T19722	T19723	arg1Of	RIP1,and
R13010	T19723	T19721	arg2Of	and,","
R13011	T19724	T19723	arg2Of	IRAK1,and
R13012	T19727	T19725	arg1Of	recognised,","
R13013	T19727	T19726	arg2Of	recognised,is
R13014	T19727	T19733	arg1Of	recognised,","
R13015	T19727	T19734	modOf	recognised,resulting
R13016	T19729	T19730	arg1Of	NEMO,and
R13017	T19731	T19730	arg2Of	TAB,and
R13018	T19732	T19727	arg1Of	proteins,recognised
R13019	T19732	T19728	arg2Of	proteins,by
R13020	T19732	T19729	arg1Of	proteins,NEMO
R13021	T19732	T19731	arg1Of	proteins,TAB
R13022	T19734	T19735	arg1Of	resulting,in
R13023	T19737	T19738	arg1Of	recruitment,and
R13024	T19738	T19735	arg2Of	and,in
R13025	T19738	T19736	arg1Of	and,the
R13026	T19738	T19740	arg1Of	and,of
R13027	T19739	T19738	arg2Of	activation,and
R13028	T19742	T19743	arg1Of	IKK2,and
R13029	T19743	T19740	arg2Of	and,of
R13030	T19743	T19741	arg1Of	and,respectively
R13031	T19744	T19743	arg2Of	TAK1,and
R13032	T19745	T19747	arg1Of	TAK1,phosphorylates
R13033	T19745	T19749	arg1Of	TAK1,activates
R13034	T19747	T19748	arg1Of	phosphorylates,and
R13035	T19748	T19746	arg1Of	and,then
R13036	T19749	T19748	arg2Of	activates,and
R13037	T19750	T19747	arg2Of	IKK2,phosphorylates
R13038	T19750	T19749	arg2Of	IKK2,activates
R13039	T19750	T19751	arg1Of	IKK2,","
R13040	T19750	T19752	arg1Of	IKK2,which
R13041	T19750	T19755	arg1Of	IKK2,phosphorylates
R13042	T19750	T19758	arg1Of	IKK2,triggering
R13043	T19754	T19753	arg2Of	turn,in
R13044	T19755	T19753	arg1Of	phosphorylates,in
R13045	T19755	T19757	arg1Of	phosphorylates,","
R13046	T19755	T19758	modOf	phosphorylates,triggering
R13047	T19756	T19755	arg2Of	IκBα,phosphorylates
R13048	T19761	T19760	arg1Of	ubiquitination,K48-linked
R13049	T19761	T19762	arg1Of	ubiquitination,and
R13050	T19762	T19758	arg2Of	and,triggering
R13051	T19762	T19759	arg1Of	and,its
R13052	T19764	T19762	arg2Of	degradation,and
R13053	T19764	T19763	arg1Of	degradation,proteasomal
R13054	T19765	T19766	arg1Of	This,allows
R13055	T19767	T19766	arg2Of	NF-κB,allows
R13056	T19767	T19768	arg1Of	NF-κB,(
R13057	T19767	T19780	arg1Of	NF-κB,translocate
R13058	T19767	T19785	arg1Of	NF-κB,promote
R13059	T19770	T19768	arg2Of	shown,(
R13060	T19770	T19769	arg1Of	shown,here
R13061	T19770	T19771	arg1Of	shown,as
R13062	T19773	T19771	arg2Of	heterodimer,as
R13063	T19773	T19772	arg1Of	heterodimer,a
R13064	T19773	T19774	arg1Of	heterodimer,of
R13065	T19775	T19776	arg1Of	p65,and
R13066	T19776	T19774	arg2Of	and,of
R13067	T19777	T19776	arg2Of	p50,and
R13068	T19778	T19768	arg3Of	),(
R13069	T19780	T19781	arg1Of	translocate,to
R13070	T19780	T19784	arg1Of	translocate,and
R13071	T19783	T19781	arg2Of	nucleus,to
R13072	T19783	T19782	arg1Of	nucleus,the
R13073	T19784	T19766	arg3Of	and,allows
R13074	T19784	T19779	arg1Of	and,to
R13075	T19785	T19784	arg2Of	promote,and
R13076	T19788	T19785	arg2Of	expression,promote
R13077	T19788	T19786	arg1Of	expression,target
R13078	T19788	T19787	arg1Of	expression,gene
R13079	T19789	T19790	arg1Of	TRAF1,","
R13080	T19789	T19791	arg1Of	TRAF1,which
R13081	T19789	T19792	arg1Of	TRAF1,has
R13082	T19789	T19798	arg1Of	TRAF1,can
R13083	T19789	T19800	arg1Of	TRAF1,regulate
R13084	T19789	T19807	arg1Of	TRAF1,competing
R13085	T19796	T19792	arg2Of	activity,has
R13086	T19796	T19793	arg1Of	activity,no
R13087	T19796	T19794	arg1Of	activity,ubiquitin
R13088	T19796	T19795	arg1Of	activity,ligase
R13089	T19800	T19797	arg1Of	regulate,","
R13090	T19800	T19798	arg2Of	regulate,can
R13091	T19800	T19799	arg1Of	regulate,negatively
R13092	T19800	T19803	arg1Of	regulate,","
R13093	T19800	T19806	arg1Of	regulate,by
R13094	T19802	T19800	arg2Of	activation,regulate
R13095	T19802	T19801	arg1Of	activation,NF-κB
R13096	T19805	T19804	arg1Of	probably,most
R13097	T19806	T19805	arg1Of	by,probably
R13098	T19807	T19806	arg2Of	competing,by
R13099	T19807	T19808	arg1Of	competing,with
R13100	T19810	T19808	arg2Of	TRAFs,with
R13101	T19810	T19809	arg1Of	TRAFs,other
R13102	T19811	T19812	arg1Of	A20,and
R13103	T19812	T19814	arg1Of	and,are
R13104	T19812	T19815	arg1Of	and,deubiquitinating
R13105	T19813	T19812	arg2Of	CYLD,and
R13106	T19815	T19814	arg2Of	deubiquitinating,are
R13107	T19816	T19815	arg2Of	enzymes,deubiquitinating
R13108	T19816	T19817	arg1Of	enzymes,that
R13109	T19816	T19818	arg1Of	enzymes,control
R13110	T19816	T19822	arg1Of	enzymes,targeting
R13111	T19818	T19821	arg1Of	control,by
R13112	T19820	T19818	arg2Of	activation,control
R13113	T19820	T19819	arg1Of	activation,NF-κB
R13114	T19822	T19821	arg2Of	targeting,by
R13115	T19825	T19822	arg2Of	proteins,targeting
R13116	T19825	T19823	arg1Of	proteins,specific
R13117	T19825	T19824	arg1Of	proteins,signalling
R13118	T19825	T19826	arg1Of	proteins,including
R13119	T19827	T19828	arg1Of	RIP1,and
R13120	T19828	T19826	arg2Of	and,including
R13121	T19828	T19830	arg1Of	and,","
R13122	T19828	T19831	arg2Of	and,to
R13123	T19828	T19832	arg1Of	and,which
R13124	T19829	T19828	arg2Of	TRAF6,and
R13125	T19833	T19834	arg1Of	they,are
R13126	T19833	T19835	arg2Of	they,recruited
R13127	T19835	T19834	arg2Of	recruited,are
R13128	T19835	T19836	modOf	recruited,using
R13129	T19835	T19844	arg1Of	recruited,and
R13130	T19840	T19836	arg2Of	proteins,using
R13131	T19840	T19837	arg1Of	proteins,specific
R13132	T19840	T19838	arg1Of	proteins,ubiquitin-binding
R13133	T19840	T19839	arg1Of	proteins,adaptor
R13134	T19840	T19842	arg1Of	proteins,as
R13135	T19842	T19841	arg1Of	as,such
R13136	T19843	T19842	arg2Of	ABIN-1,as
R13137	T19844	T19831	arg1Of	and,to
R13138	T19846	T19845	arg1Of	miR-146,p62.
R13139	T19846	T19847	arg1Of	miR-146,is
R13140	T19846	T19848	arg2Of	miR-146,thought
R13141	T19846	T19851	arg1Of	miR-146,regulate
R13142	T19846	T19855	arg1Of	miR-146,inhibiting
R13143	T19848	T19844	arg2Of	thought,and
R13144	T19848	T19847	arg2Of	thought,is
R13145	T19851	T19848	arg3Of	regulate,thought
R13146	T19851	T19849	arg1Of	regulate,to
R13147	T19851	T19850	arg1Of	regulate,negatively
R13148	T19851	T19854	arg1Of	regulate,by
R13149	T19853	T19851	arg2Of	signalling,regulate
R13150	T19853	T19852	arg1Of	signalling,TLR
R13151	T19855	T19854	arg2Of	inhibiting,by
R13152	T19856	T19855	arg2Of	expression,inhibiting
R13153	T19856	T19857	arg1Of	expression,of
R13154	T19858	T19859	arg1Of	IRAK1,and
R13155	T19859	T19857	arg2Of	and,of
R13156	T19860	T19859	arg2Of	TRAF6,and
R13157	T19864	T19863	arg1Of	signalling,TLR
R13158	T19864	T19865	arg1Of	signalling,can
R13159	T19864	T19867	arg1Of	signalling,be
R13160	T19864	T19868	arg2Of	signalling,inhibited
R13161	T19868	T19861	arg1Of	inhibited,Finally
R13162	T19868	T19862	arg1Of	inhibited,","
R13163	T19868	T19865	arg2Of	inhibited,can
R13164	T19868	T19866	arg1Of	inhibited,also
R13165	T19868	T19867	arg2Of	inhibited,be
R13166	T19873	T19868	arg1Of	SIGIRR,inhibited
R13167	T19873	T19869	arg2Of	SIGIRR,by
R13168	T19873	T19870	arg1Of	SIGIRR,the
R13169	T19873	T19871	arg1Of	SIGIRR,transmembrane
R13170	T19873	T19872	arg1Of	SIGIRR,protein
R13171	T19873	T19874	arg1Of	SIGIRR,","
R13172	T19873	T19875	arg1Of	SIGIRR,which
R13173	T19873	T19876	arg1Of	SIGIRR,has
R13174	T19873	T19877	arg1Of	SIGIRR,been
R13175	T19873	T19878	arg2Of	SIGIRR,proposed
R13176	T19873	T19880	arg1Of	SIGIRR,compete
R13177	T19878	T19876	arg2Of	proposed,has
R13178	T19878	T19877	arg2Of	proposed,been
R13179	T19880	T19878	arg3Of	compete,proposed
R13180	T19880	T19879	arg1Of	compete,to
R13181	T19880	T19881	arg1Of	compete,with
R13182	T19882	T19881	arg2Of	TLR4,with
R13183	T19882	T19883	arg1Of	TLR4,for
R13184	T19884	T19883	arg2Of	binding,for
R13185	T19884	T19885	arg1Of	binding,to
R13186	T19886	T19887	arg1Of	IRAK1,and
R13187	T19887	T19885	arg2Of	and,to
R13188	T19888	T19887	arg2Of	TRAF6,and
R13189	T19890	T19889	arg1Of	expression,The
R13190	T19890	T19891	arg1Of	expression,of
R13191	T19890	T19898	arg1Of	expression,is
R13192	T19890	T19902	arg1Of	expression,implicating
R13193	T19892	T19891	arg2Of	many,of
R13194	T19892	T19893	arg1Of	many,of
R13195	T19897	T19893	arg2Of	molecules,of
R13196	T19897	T19894	arg1Of	molecules,these
R13197	T19897	T19895	arg1Of	molecules,negative
R13198	T19897	T19896	arg1Of	molecules,regulatory
R13199	T19898	T19901	arg1Of	is,","
R13200	T19898	T19902	modOf	is,implicating
R13201	T19899	T19898	arg2Of	NF-κB,is
R13202	T19899	T19900	arg1Of	NF-κB,dependent
R13203	T19902	T19904	arg1Of	implicating,in
R13204	T19903	T19902	arg2Of	them,implicating
R13205	T19908	T19904	arg2Of	regulation,in
R13206	T19908	T19905	arg1Of	regulation,the
R13207	T19908	T19906	arg1Of	regulation,negative
R13208	T19908	T19907	arg1Of	regulation,feedback
R13209	T19908	T19909	arg1Of	regulation,of
R13210	T19911	T19909	arg2Of	activation,of
R13211	T19911	T19910	arg1Of	activation,NF-κB
R13212	T19912	T19913	arg1Of	ABIN,","
R13213	T19912	T19918	arg1Of	ABIN,;
R13214	T19915	T19913	arg2Of	inhibitor,","
R13215	T19915	T19914	arg1Of	inhibitor,A20-binding
R13216	T19915	T19916	arg1Of	inhibitor,of
R13217	T19917	T19916	arg2Of	NF-κB,of
R13218	T19919	T19918	arg2Of	cIAP,;
R13219	T19919	T19920	arg1Of	cIAP,","
R13220	T19922	T19920	arg2Of	inhibitor,","
R13221	T19922	T19921	arg1Of	inhibitor,cellular
R13222	T19922	T19923	arg1Of	inhibitor,of
R13223	T19924	T19923	arg2Of	apoptosis,of
R13224	T19926	T19927	arg1Of	CYLD,","
R13225	T19928	T19927	arg2Of	cylindromatosis,","
R13226	T19930	T19929	arg2Of	IKK,;
R13227	T19930	T19931	arg1Of	IKK,","
R13228	T19930	T19934	arg1Of	IKK,;
R13229	T19933	T19931	arg2Of	kinase,","
R13230	T19933	T19932	arg1Of	kinase,IκB
R13231	T19935	T19934	arg2Of	IκB,;
R13232	T19935	T19936	arg1Of	IκB,","
R13233	T19935	T19940	arg1Of	IκB,;
R13234	T19937	T19936	arg2Of	inhibitor,","
R13235	T19937	T19938	arg1Of	inhibitor,of
R13236	T19939	T19938	arg2Of	NF-κB,of
R13237	T19941	T19940	arg2Of	IRAK,;
R13238	T19941	T19942	arg1Of	IRAK,","
R13239	T19944	T19942	arg2Of	kinase,","
R13242	T19952	T19947	arg2Of	gene,","
R13243	T19952	T19948	arg1Of	gene,myeloid
R13244	T19952	T19949	arg1Of	gene,differentiation
R13245	T19952	T19950	arg1Of	gene,primary
R13246	T19952	T19951	arg1Of	gene,response
R13247	T19952	T19953	arg1Of	gene,88
R13248	T19955	T19954	arg2Of	NEMO,;
R13249	T19955	T19956	arg1Of	NEMO,","
R13250	T19959	T19956	arg2Of	modulator,","
R13251	T19959	T19957	arg1Of	modulator,NF-κB
R13252	T19959	T19958	arg1Of	modulator,essential
R13253	T19961	T19962	arg1Of	NF,","
R13254	T19964	T19962	arg2Of	factor,","
R13255	T19964	T19963	arg1Of	factor,nuclear
R13256	T19966	T19967	arg1Of	RANK,","
R13257	T19966	T19972	arg1Of	RANK,;
R13258	T19969	T19967	arg2Of	activator,","
R13259	T19969	T19968	arg1Of	activator,receptor
R13260	T19969	T19970	arg1Of	activator,of
R13261	T19971	T19970	arg2Of	NF-κB,of
R13262	T19973	T19972	arg2Of	RIP1,;
R13263	T19973	T19974	arg1Of	RIP1,","
R13264	T19973	T19979	arg1Of	RIP1,;
R13265	T19977	T19974	arg2Of	protein,","
R13266	T19977	T19975	arg1Of	protein,receptor
R13267	T19977	T19976	arg1Of	protein,interacting
R13268	T19977	T19978	arg1Of	protein,1
R13269	T19980	T19979	arg2Of	SIGIRR,;
R13270	T19980	T19981	arg1Of	SIGIRR,","
R13271	T19982	T19981	arg2Of	single-immunoglobulinIL-1,","
R13272	T19982	T19983	arg1Of	single-immunoglobulinIL-1,receptor-related
R13273	T19985	T19986	arg1Of	TIR,","
R13274	T19985	T19989	arg1Of	TIR,;
R13275	T19988	T19986	arg2Of	receptor/IL-1R,","
R13276	T19988	T19987	arg1Of	receptor/IL-1R,Toll-like
R13277	T19990	T19989	arg2Of	TRAF,;
R13278	T19990	T19991	arg1Of	TRAF,","
R13279	T19990	T19995	arg1Of	TRAF,;
R13280	T19994	T19991	arg2Of	factor,","
R13281	T19994	T19992	arg1Of	factor,TNF
R13282	T19994	T19993	arg1Of	factor,receptor-associated
R13283	T19996	T19995	arg2Of	TLR,;
R13284	T19996	T19997	arg1Of	TLR,","
R13285	T19996	T20000	arg1Of	TLR,;
R13286	T19999	T19997	arg2Of	receptor,","
R13287	T19999	T19998	arg1Of	receptor,Toll-like
R13288	T20001	T20000	arg2Of	TNF,;
R13289	T20001	T20002	arg1Of	TNF,","
R13290	T20005	T20002	arg2Of	factor,","
R13291	T20005	T20003	arg1Of	factor,tumour
R13292	T20005	T20004	arg1Of	factor,necrosis

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T20034	1720-1729	http://purl.obolibrary.org/obo/GO_0097194	denotes	apoptosis
T20033	1720-1729	http://purl.obolibrary.org/obo/GO_0006915	denotes	apoptosis
T20032	1698-1706	http://purl.obolibrary.org/obo/GO_0007349	denotes	cellular
T20031	1776-1794	http://purl.obolibrary.org/obo/GO_0007252	denotes	inhibitor of NF-κB
T20030	1672-1690	http://purl.obolibrary.org/obo/GO_0007252	denotes	inhibitor of NF-κB
T20029	1776-1794	http://purl.obolibrary.org/obo/GO_0032088	denotes	inhibitor of NF-κB
T20028	1672-1690	http://purl.obolibrary.org/obo/GO_0032088	denotes	inhibitor of NF-κB
T20027	1622-1632	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T20026	1011-1035	http://purl.obolibrary.org/obo/GO_0004843	denotes	deubiquitinating enzymes
T20025	1952-1970	http://purl.obolibrary.org/obo/GO_0051092	denotes	activator of NF-κB
T20024	1636-1652	http://purl.obolibrary.org/obo/GO_0051092	denotes	NF-κB activation
T20023	1049-1065	http://purl.obolibrary.org/obo/GO_0051092	denotes	NF-κB activation
T20022	931-947	http://purl.obolibrary.org/obo/GO_0051092	denotes	NF-κB activation
T20021	890-905	http://purl.obolibrary.org/obo/GO_0016874	denotes	ligase activity
T20020	880-905	http://purl.obolibrary.org/obo/GO_0034450	denotes	ubiquitin ligase activity
T20019	880-905	http://purl.obolibrary.org/obo/GO_1904667	denotes	ubiquitin ligase activity
T20018	880-905	http://purl.obolibrary.org/obo/GO_0061630	denotes	ubiquitin ligase activity
T20017	880-905	http://purl.obolibrary.org/obo/GO_1904668	denotes	ubiquitin ligase activity
T20016	880-905	http://purl.obolibrary.org/obo/GO_1990757	denotes	ubiquitin ligase activity
T20015	880-905	http://purl.obolibrary.org/obo/GO_1904666	denotes	ubiquitin ligase activity
T20014	880-905	http://purl.obolibrary.org/obo/GO_0050372	denotes	ubiquitin ligase activity
T20013	880-905	http://purl.obolibrary.org/obo/GO_0004842	denotes	ubiquitin ligase activity
T20012	843-858	http://purl.obolibrary.org/obo/GO_0010467	denotes	gene expression
T20011	718-729	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T20010	217-222	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T20009	1351-1361	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T20008	1282-1292	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T20007	1088-1098	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T20006	16-26	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T20042	2168-2176	http://purl.obolibrary.org/obo/GO_0070265	denotes	necrosis
T20041	2168-2176	http://purl.obolibrary.org/obo/GO_0019835	denotes	necrosis
T20040	2168-2176	http://purl.obolibrary.org/obo/GO_0008219	denotes	necrosis
T20039	2168-2176	http://purl.obolibrary.org/obo/GO_0001906	denotes	necrosis
T20038	2077-2088	http://purl.obolibrary.org/obo/GO_0004896	denotes	receptor/IL
T20037	2086-2091	http://purl.obolibrary.org/obo/GO_0004908	denotes	IL-1R
T20036	1802-1807	http://purl.obolibrary.org/obo/GO_0004908	denotes	IL-1R
T20035	1754-1757	http://purl.obolibrary.org/obo/GO_0008384	denotes	IKK

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T20062	2077-2088	http://purl.obolibrary.org/obo/GO_0004896	denotes	receptor/IL
T20061	2086-2091	http://purl.obolibrary.org/obo/GO_0004908	denotes	IL-1R
T20060	1802-1807	http://purl.obolibrary.org/obo/GO_0004908	denotes	IL-1R
T20059	1754-1757	http://purl.obolibrary.org/obo/GO_0008384	denotes	IKK
T20058	1461-1477	http://purl.obolibrary.org/obo/GO_0035662	denotes	TLR4 for binding
T20057	1177-1194	http://purl.obolibrary.org/obo/GO_0043130	denotes	ubiquitin-binding
T20056	1011-1035	http://purl.obolibrary.org/obo/GO_0004843	denotes	deubiquitinating enzymes
T20055	890-905	http://purl.obolibrary.org/obo/GO_0016874	denotes	ligase activity
T20054	880-905	http://purl.obolibrary.org/obo/GO_0034450	denotes	ubiquitin ligase activity
T20053	880-905	http://purl.obolibrary.org/obo/GO_0061630	denotes	ubiquitin ligase activity
T20052	880-905	http://purl.obolibrary.org/obo/GO_1990757	denotes	ubiquitin ligase activity
T20051	880-905	http://purl.obolibrary.org/obo/GO_0050372	denotes	ubiquitin ligase activity
T20050	880-905	http://purl.obolibrary.org/obo/GO_0004842	denotes	ubiquitin ligase activity
T20049	1177-1186	http://purl.obolibrary.org/obo/GO_0031386	denotes	ubiquitin
T20048	880-889	http://purl.obolibrary.org/obo/GO_0031386	denotes	ubiquitin
T20047	346-355	http://purl.obolibrary.org/obo/GO_0031386	denotes	ubiquitin
T20046	1664-1671	http://purl.obolibrary.org/obo/GO_0005488	denotes	binding
T20045	1470-1477	http://purl.obolibrary.org/obo/GO_0005488	denotes	binding
T20044	1187-1194	http://purl.obolibrary.org/obo/GO_0005488	denotes	binding
T20043	52-58	http://purl.obolibrary.org/obo/GO_0005488	denotes	Ligand

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T20066	1391-1404	http://purl.obolibrary.org/obo/GO_0044214	denotes	transmembrane
T20065	1391-1404	http://purl.obolibrary.org/obo/GO_0016021	denotes	transmembrane
T20064	816-823	http://purl.obolibrary.org/obo/GO_0005634	denotes	nucleus
T20063	82-90	http://purl.obolibrary.org/obo/GO_0016020	denotes	membrane

sentences

Id	Subject	Object	Predicate	Lexical cue
T19469	1654-2184	Sentence	denotes	ABIN, A20-binding inhibitor of NF-κB; cIAP, cellular inhibitor of apoptosis; CYLD, cylindromatosis; IKK, IκB kinase; IκB, inhibitor of NF-κB; IRAK, IL-1R-associated kinase; MyD88, myeloid differentiation primary response gene 88; NEMO, NF-κB essential modulator; NF, nuclear factor; RANK, receptor activator of NF-κB; RIP1, receptor interacting protein 1; SIGIRR, single-immunoglobulinIL-1 receptor-related; TIR, Toll-like receptor/IL-1R; TRAF, TNF receptor-associated factor; TLR, Toll-like receptor; TNF, tumour necrosis factor.
T19468	1498-1653	Sentence	denotes	The expression of many of these negative regulatory molecules is NF-κB dependent, implicating them in the negative feedback regulation of NF-κB activation.
T19467	1338-1497	Sentence	denotes	Finally, TLR signalling can also be inhibited by the transmembrane protein SIGIRR, which has been proposed to compete with TLR4 for binding to IRAK1 and TRAF6.
T19466	994-1337	Sentence	denotes	A20 and CYLD are deubiquitinating enzymes that control NF-κB activation by targeting specific signalling proteins including RIP1 and TRAF6, to which they are recruited using specific ubiquitin-binding adaptor proteins such as ABIN-1 and p62. miR-146 is thought to negatively regulate TLR signalling by inhibiting expression of IRAK1 and TRAF6.
T19465	860-993	Sentence	denotes	TRAF1, which has no ubiquitin ligase activity, can negatively regulate NF-κB activation, most probably by competing with other TRAFs.
T19464	731-859	Sentence	denotes	This allows NF-κB (here shown as a heterodimer of p65 and p50) to translocate to the nucleus and promote target gene expression.
T19463	581-730	Sentence	denotes	TAK1 then phosphorylates and activates IKK2, which in turn phosphorylates IκBα, triggering its K48-linked ubiquitination and proteasomal degradation.
T19462	410-580	Sentence	denotes	K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1, is recognised by NEMO and TAB proteins, resulting in the recruitment and activation of respectively IKK2 and TAK1.
T19461	52-409	Sentence	denotes	Ligand engagement of specific membrane receptors such as TNFR1, CD40, RANK, and TLR4 trigger the recruitment of specific adaptor proteins (TNF receptor 1-associated death domain protein (TRADD), MyD88, MAL, TIR domain-containing adaptor-inducing IFNβ (TRIF)), kinases (RIP1, IRAK1, IRAK4), and ubiquitin ligases (TRAF2, TRAF6, cIAP1, cIAP2) to the receptor.
T19460	0-51	Sentence	denotes	Canonical NF-κB signalling and negative regulators.
T47	52-409	Sentence	denotes	Ligand engagement of specific membrane receptors such as TNFR1, CD40, RANK, and TLR4 trigger the recruitment of specific adaptor proteins (TNF receptor 1-associated death domain protein (TRADD), MyD88, MAL, TIR domain-containing adaptor-inducing IFNβ (TRIF)), kinases (RIP1, IRAK1, IRAK4), and ubiquitin ligases (TRAF2, TRAF6, cIAP1, cIAP2) to the receptor.
T48	410-580	Sentence	denotes	K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1, is recognised by NEMO and TAB proteins, resulting in the recruitment and activation of respectively IKK2 and TAK1.
T49	581-730	Sentence	denotes	TAK1 then phosphorylates and activates IKK2, which in turn phosphorylates IκBα, triggering its K48-linked ubiquitination and proteasomal degradation.
T50	731-859	Sentence	denotes	This allows NF-κB (here shown as a heterodimer of p65 and p50) to translocate to the nucleus and promote target gene expression.
T51	860-993	Sentence	denotes	TRAF1, which has no ubiquitin ligase activity, can negatively regulate NF-κB activation, most probably by competing with other TRAFs.
T52	994-1337	Sentence	denotes	A20 and CYLD are deubiquitinating enzymes that control NF-κB activation by targeting specific signalling proteins including RIP1 and TRAF6, to which they are recruited using specific ubiquitin-binding adaptor proteins such as ABIN-1 and p62. miR-146 is thought to negatively regulate TLR signalling by inhibiting expression of IRAK1 and TRAF6.
T53	1338-1497	Sentence	denotes	Finally, TLR signalling can also be inhibited by the transmembrane protein SIGIRR, which has been proposed to compete with TLR4 for binding to IRAK1 and TRAF6.
T54	1498-1653	Sentence	denotes	The expression of many of these negative regulatory molecules is NF-κB dependent, implicating them in the negative feedback regulation of NF-κB activation.
T55	1654-2184	Sentence	denotes	ABIN, A20-binding inhibitor of NF-κB; cIAP, cellular inhibitor of apoptosis; CYLD, cylindromatosis; IKK, IκB kinase; IκB, inhibitor of NF-κB; IRAK, IL-1R-associated kinase; MyD88, myeloid differentiation primary response gene 88; NEMO, NF-κB essential modulator; NF, nuclear factor; RANK, receptor activator of NF-κB; RIP1, receptor interacting protein 1; SIGIRR, single-immunoglobulinIL-1 receptor-related; TIR, Toll-like receptor/IL-1R; TRAF, TNF receptor-associated factor; TLR, Toll-like receptor; TNF, tumour necrosis factor.

simple1

Id	Subject	Object	Predicate	Lexical cue
T20178	2161-2183	Protein	denotes	tumour necrosis factor
T20177	2156-2159	Protein	denotes	TNF
T20176	2018-2060	Protein	denotes	single-immunoglobulinIL-1 receptor-related
T20175	2010-2016	Protein	denotes	SIGIRR
T20174	1978-2008	Protein	denotes	receptor interacting protein 1
T20173	1972-1976	Protein	denotes	RIP1
T20172	1943-1970	Protein	denotes	receptor activator of NF-κB
T20171	1937-1941	Protein	denotes	RANK
T20170	1890-1915	Protein	denotes	NF-κB essential modulator
T20169	1884-1888	Protein	denotes	NEMO
T20168	1834-1882	Protein	denotes	myeloid differentiation primary response gene 88
T20167	1827-1832	Protein	denotes	MyD88
T20166	1737-1752	Protein	denotes	cylindromatosis
T20165	1731-1735	Protein	denotes	CYLD
T20164	1660-1690	Protein	denotes	A20-binding inhibitor of NF-κB
T20163	1654-1658	Protein	denotes	ABIN
T20162	1491-1496	Protein	denotes	TRAF6
T20161	1481-1486	Protein	denotes	IRAK1
T20160	1461-1465	Protein	denotes	TLR4
T20159	1413-1419	Protein	denotes	SIGIRR
T20158	1331-1336	Protein	denotes	TRAF6
T20157	1321-1326	Protein	denotes	IRAK1
T20156	1231-1234	Protein	denotes	p62
T20155	1220-1226	Protein	denotes	ABIN-1
T20154	1127-1132	Protein	denotes	TRAF6
T20153	1118-1122	Protein	denotes	RIP1
T20152	1002-1006	Protein	denotes	CYLD
T20151	994-997	Protein	denotes	A20
T20150	860-865	Protein	denotes	TRAF1
T20149	789-792	Protein	denotes	p50
T20148	781-784	Protein	denotes	p65
T20147	655-659	Protein	denotes	IκBα
T20146	620-624	Protein	denotes	IKK2
T20145	581-585	Protein	denotes	TAK1
T20144	575-579	Protein	denotes	TAK1
T20143	566-570	Protein	denotes	IKK2
T20142	483-487	Protein	denotes	NEMO
T20141	459-464	Protein	denotes	IRAK1
T20140	450-454	Protein	denotes	RIP1
T20139	386-391	Protein	denotes	cIAP2
T20138	379-384	Protein	denotes	cIAP1
T20137	372-377	Protein	denotes	TRAF6
T20136	365-370	Protein	denotes	TRAF2
T20135	334-339	Protein	denotes	IRAK4
T20134	327-332	Protein	denotes	IRAK1
T20133	321-325	Protein	denotes	RIP1
T20132	304-308	Protein	denotes	TRIF
T20131	259-302	Protein	denotes	TIR domain-containing adaptor-inducing IFNβ
T20130	254-257	Protein	denotes	MAL
T20129	247-252	Protein	denotes	MyD88
T20128	239-244	Protein	denotes	TRADD
T20127	191-237	Protein	denotes	TNF receptor 1-associated death domain protein
T20126	132-136	Protein	denotes	TLR4
T20125	122-126	Protein	denotes	RANK
T20124	116-120	Protein	denotes	CD40
T20123	109-114	Protein	denotes	TNFR1

BioNLP16_DUT

Id	Subject	Object	Predicate	Lexical cue
T21070	1470-1477	Binding	denotes	binding
T21069	1448-1455	Binding	denotes	compete
T21068	1296-1306	Negative_regulation	denotes	inhibiting
T21067	1307-1317	Gene_expression	denotes	expression
T21066	1069-1078	Binding	denotes	targeting
T21065	766-777	Binding	denotes	heterodimer
T21064	640-654	Phosphorylation	denotes	phosphorylates
T21063	591-605	Phosphorylation	denotes	phosphorylates
T21062	610-619	Positive_regulation	denotes	activates
T21061	421-439	Binding	denotes	polyubiquitination
T21060	539-549	Positive_regulation	denotes	activation
T21059	523-534	Binding	denotes	recruitment
T21058	59-69	Binding	denotes	engagement
T21057	137-144	Positive_regulation	denotes	trigger
T21056	149-160	Binding	denotes	recruitment
T21055	2161-2183	Protein	denotes	tumour necrosis factor
T21054	2156-2159	Protein	denotes	TNF
T21053	2018-2060	Protein	denotes	single-immunoglobulinIL-1 receptor-related
T21052	2010-2016	Protein	denotes	SIGIRR
T21051	1978-2008	Protein	denotes	receptor interacting protein 1
T21050	1972-1976	Protein	denotes	RIP1
T21049	1943-1970	Protein	denotes	receptor activator of NF-κB
T21048	1937-1941	Protein	denotes	RANK
T21047	1890-1915	Protein	denotes	NF-κB essential modulator
T21046	1884-1888	Protein	denotes	NEMO
T21045	1834-1882	Protein	denotes	myeloid differentiation primary response gene 88
T21044	1827-1832	Protein	denotes	MyD88
T21043	1737-1752	Protein	denotes	cylindromatosis
T21042	1731-1735	Protein	denotes	CYLD
T21041	1660-1690	Protein	denotes	A20-binding inhibitor of NF-κB
T21040	1654-1658	Protein	denotes	ABIN
T21039	1491-1496	Protein	denotes	TRAF6
T21038	1481-1486	Protein	denotes	IRAK1
T21037	1461-1465	Protein	denotes	TLR4
T21036	1413-1419	Protein	denotes	SIGIRR
T21035	1331-1336	Protein	denotes	TRAF6
T21034	1321-1326	Protein	denotes	IRAK1
T21033	1231-1234	Protein	denotes	p62
T21032	1220-1226	Protein	denotes	ABIN-1
T21031	1127-1132	Protein	denotes	TRAF6
T21030	1118-1122	Protein	denotes	RIP1
T21029	1002-1006	Protein	denotes	CYLD
T21009	116-120	Protein	denotes	CD40
T21008	386-391	Protein	denotes	cIAP2
T21007	379-384	Protein	denotes	cIAP1
T21006	372-377	Protein	denotes	TRAF6
T21005	365-370	Protein	denotes	TRAF2
T21004	334-339	Protein	denotes	IRAK4
T21003	327-332	Protein	denotes	IRAK1
T21002	321-325	Protein	denotes	RIP1
T21001	304-308	Protein	denotes	TRIF
T21000	109-114	Protein	denotes	TNFR1
T21010	122-126	Protein	denotes	RANK
T21028	994-997	Protein	denotes	A20
T21027	860-865	Protein	denotes	TRAF1
T21026	789-792	Protein	denotes	p50
T21025	781-784	Protein	denotes	p65
T21024	655-659	Protein	denotes	IκBα
T21023	620-624	Protein	denotes	IKK2
T21022	581-585	Protein	denotes	TAK1
T21021	575-579	Protein	denotes	TAK1
T21020	566-570	Protein	denotes	IKK2
T21019	483-487	Protein	denotes	NEMO
T21018	459-464	Protein	denotes	IRAK1
T21017	450-454	Protein	denotes	RIP1
T21016	259-302	Protein	denotes	TIR domain-containing adaptor-inducing IFNβ
T21015	254-257	Protein	denotes	MAL
T21014	247-252	Protein	denotes	MyD88
T21013	239-244	Protein	denotes	TRADD
T21012	191-237	Protein	denotes	TNF receptor 1-associated death domain protein
T21011	132-136	Protein	denotes	TLR4
R13828	T21000	T21058	themeOf	TNFR1,engagement
R13829	T21001	T21056	themeOf	TRIF,recruitment
R13830	T21002	T21056	themeOf	RIP1,recruitment
R13831	T21003	T21056	themeOf	IRAK1,recruitment
R13832	T21004	T21056	themeOf	IRAK4,recruitment
R13833	T21005	T21056	themeOf	TRAF2,recruitment
R13834	T21006	T21056	themeOf	TRAF6,recruitment
R13835	T21007	T21056	themeOf	cIAP1,recruitment
R13836	T21008	T21056	themeOf	cIAP2,recruitment
R13837	T21009	T21058	themeOf	CD40,engagement
R13838	T21010	T21058	themeOf	RANK,engagement
R13839	T21011	T21058	themeOf	TLR4,engagement
R13840	T21012	T21056	themeOf	TNF receptor 1-associated death domain protein,recruitment
R13841	T21013	T21056	themeOf	TRADD,recruitment
R13842	T21014	T21056	themeOf	MyD88,recruitment
R13843	T21015	T21056	themeOf	MAL,recruitment
R13844	T21016	T21056	themeOf	TIR domain-containing adaptor-inducing IFNβ,recruitment
R13845	T21017	T21061	themeOf	RIP1,polyubiquitination
R13846	T21018	T21061	themeOf	IRAK1,polyubiquitination
R13847	T21020	T21059	themeOf	IKK2,recruitment
R13848	T21021	T21059	themeOf	TAK1,recruitment
R13849	T21021	T21060	themeOf	TAK1,activation
R13850	T21022	T21063	themeOf	TAK1,phosphorylates
R13851	T21022	T21062	causeOf	TAK1,activates
R13852	T21023	T21063	themeOf	IKK2,phosphorylates
R13853	T21023	T21062	themeOf	IKK2,activates
R13854	T21024	T21064	themeOf	IκBα,phosphorylates
R13855	T21025	T21065	themeOf	p65,heterodimer
R13856	T21026	T21065	themeOf	p50,heterodimer
R13857	T21028	T21066	themeOf	A20,targeting
R13858	T21028	T21066	themeOf	A20,targeting
R13859	T21030	T21066	themeOf	RIP1,targeting
R13860	T21031	T21066	themeOf	TRAF6,targeting
R13861	T21034	T21067	themeOf	IRAK1,expression
R13862	T21035	T21067	themeOf	TRAF6,expression
R13863	T21037	T21069	themeOf	TLR4,compete
R13864	T21037	T21070	themeOf	TLR4,binding
R13865	T21037	T21070	themeOf	TLR4,binding
R13866	T21038	T21070	themeOf	IRAK1,binding
R13867	T21039	T21070	themeOf	TRAF6,binding
R13868	T21056	T21057	themeOf	recruitment,trigger
R13869	T21056	T21057	themeOf	recruitment,trigger
R13870	T21056	T21057	themeOf	recruitment,trigger
R13871	T21056	T21057	themeOf	recruitment,trigger
R13872	T21056	T21057	themeOf	recruitment,trigger
R13873	T21056	T21057	themeOf	recruitment,trigger
R13874	T21056	T21057	themeOf	recruitment,trigger
R13875	T21056	T21057	themeOf	recruitment,trigger
R13876	T21056	T21057	themeOf	recruitment,trigger
R13880	T21056	T21057	themeOf	recruitment,trigger
R13881	T21067	T21068	themeOf	expression,inhibiting
R13882	T21067	T21068	themeOf	expression,inhibiting
R13877	T21056	T21057	themeOf	recruitment,trigger
R13878	T21056	T21057	themeOf	recruitment,trigger
R13879	T21056	T21057	themeOf	recruitment,trigger

BioNLP16_Messiy

Id	Subject	Object	Predicate	Lexical cue
T20659	1374-1383	Negative_regulation	denotes	inhibited
T20658	1470-1477	Binding	denotes	binding
T20649	421-439	Positive_regulation	denotes	polyubiquitination
T20648	506-515	Positive_regulation	denotes	resulting
T20647	59-69	Binding	denotes	engagement
T20646	149-160	Binding	denotes	recruitment
T20645	2161-2183	Protein	denotes	tumour necrosis factor
T20644	2156-2159	Protein	denotes	TNF
T20643	2018-2060	Protein	denotes	single-immunoglobulinIL-1 receptor-related
T20642	2010-2016	Protein	denotes	SIGIRR
T20641	1978-2008	Protein	denotes	receptor interacting protein 1
T20640	1972-1976	Protein	denotes	RIP1
T20639	1943-1970	Protein	denotes	receptor activator of NF-κB
T20638	1937-1941	Protein	denotes	RANK
T20637	1890-1915	Protein	denotes	NF-κB essential modulator
T20636	1884-1888	Protein	denotes	NEMO
T20635	1834-1882	Protein	denotes	myeloid differentiation primary response gene 88
T20634	1827-1832	Protein	denotes	MyD88
T20633	1737-1752	Protein	denotes	cylindromatosis
T20632	1731-1735	Protein	denotes	CYLD
T20631	1660-1690	Protein	denotes	A20-binding inhibitor of NF-κB
T20630	1654-1658	Protein	denotes	ABIN
T20629	1491-1496	Protein	denotes	TRAF6
T20628	1481-1486	Protein	denotes	IRAK1
T20627	1461-1465	Protein	denotes	TLR4
T20626	1413-1419	Protein	denotes	SIGIRR
T20625	1331-1336	Protein	denotes	TRAF6
T20624	1321-1326	Protein	denotes	IRAK1
T20623	1231-1234	Protein	denotes	p62
T20622	1220-1226	Protein	denotes	ABIN-1
T20621	1127-1132	Protein	denotes	TRAF6
T20620	1118-1122	Protein	denotes	RIP1
T20619	1002-1006	Protein	denotes	CYLD
T20618	994-997	Protein	denotes	A20
T20617	860-865	Protein	denotes	TRAF1
T20616	789-792	Protein	denotes	p50
T20615	781-784	Protein	denotes	p65
T20614	655-659	Protein	denotes	IκBα
T20613	620-624	Protein	denotes	IKK2
T20612	581-585	Protein	denotes	TAK1
T20611	575-579	Protein	denotes	TAK1
T20610	566-570	Protein	denotes	IKK2
T20609	483-487	Protein	denotes	NEMO
T20608	459-464	Protein	denotes	IRAK1
T20607	450-454	Protein	denotes	RIP1
T20606	259-302	Protein	denotes	TIR domain-containing adaptor-inducing IFNβ
T20605	254-257	Protein	denotes	MAL
T20604	247-252	Protein	denotes	MyD88
T20603	239-244	Protein	denotes	TRADD
T20602	191-237	Protein	denotes	TNF receptor 1-associated death domain protein
T20601	132-136	Protein	denotes	TLR4
T20600	122-126	Protein	denotes	RANK
T20599	116-120	Protein	denotes	CD40
T20598	386-391	Protein	denotes	cIAP2
T20597	379-384	Protein	denotes	cIAP1
T20596	372-377	Protein	denotes	TRAF6
T20595	365-370	Protein	denotes	TRAF2
T20594	334-339	Protein	denotes	IRAK4
T20593	327-332	Protein	denotes	IRAK1
T20592	321-325	Protein	denotes	RIP1
T20591	304-308	Protein	denotes	TRIF
T20590	109-114	Protein	denotes	TNFR1
T20657	1448-1455	Negative_regulation	denotes	compete
T20656	1307-1317	Gene_expression	denotes	expression
T20655	1296-1306	Negative_regulation	denotes	inhibiting
T20654	1069-1078	Binding	denotes	targeting
T20653	640-654	Phosphorylation	denotes	phosphorylates
T20652	610-619	Positive_regulation	denotes	activates
T20651	591-605	Phosphorylation	denotes	phosphorylates
T20650	523-534	Binding	denotes	recruitment
R13674	T20590	T20647	themeOf	TNFR1,engagement
R13675	T20591	T20646	themeOf	TRIF,recruitment
R13676	T20592	T20646	themeOf	RIP1,recruitment
R13677	T20593	T20646	themeOf	IRAK1,recruitment
R13678	T20594	T20646	themeOf	IRAK4,recruitment
R13679	T20595	T20646	themeOf	TRAF2,recruitment
R13680	T20596	T20646	themeOf	TRAF6,recruitment
R13681	T20597	T20646	themeOf	cIAP1,recruitment
R13682	T20598	T20646	themeOf	cIAP2,recruitment
R13683	T20601	T20647	themeOf	TLR4,engagement
R13684	T20602	T20646	themeOf	TNF receptor 1-associated death domain protein,recruitment
R13685	T20603	T20646	themeOf	TRADD,recruitment
R13686	T20604	T20646	themeOf	MyD88,recruitment
R13687	T20605	T20646	themeOf	MAL,recruitment
R13688	T20606	T20646	themeOf	TIR domain-containing adaptor-inducing IFNβ,recruitment
R13689	T20607	T20649	themeOf	RIP1,polyubiquitination
R13690	T20608	T20649	themeOf	IRAK1,polyubiquitination
R13691	T20610	T20650	themeOf	IKK2,recruitment
R13692	T20611	T20650	themeOf	TAK1,recruitment
R13693	T20612	T20651	themeOf	TAK1,phosphorylates
R13694	T20612	T20652	causeOf	TAK1,activates
R13695	T20613	T20651	themeOf	IKK2,phosphorylates
R13696	T20613	T20652	themeOf	IKK2,activates
R13697	T20614	T20653	themeOf	IκBα,phosphorylates
R13698	T20620	T20654	themeOf	RIP1,targeting
R13699	T20624	T20656	themeOf	IRAK1,expression
R13700	T20625	T20656	themeOf	TRAF6,expression
R13701	T20626	T20659	themeOf	SIGIRR,inhibited
R13702	T20627	T20657	themeOf	TLR4,compete
R13703	T20627	T20658	themeOf	TLR4,binding
R13704	T20627	T20658	themeOf	TLR4,binding
R13705	T20628	T20658	themeOf	IRAK1,binding
R13706	T20629	T20658	themeOf	TRAF6,binding
R13707	T20650	T20648	themeOf	recruitment,resulting
R13708	T20650	T20648	themeOf	recruitment,resulting
R13709	T20656	T20655	themeOf	expression,inhibiting
R13710	T20656	T20655	themeOf	expression,inhibiting
R13711	T20658	T20657	themeOf	binding,compete
R13712	T20658	T20657	themeOf	binding,compete

bionlp-st-ge-2016-test-ihmc

Id	Subject	Object	Predicate	Lexical cue
T21192	1498-1578	Regulation	denotes	The expression of many of these negative regulatory molecules is NF-κB dependent
T21191	1374-1420	Negative_regulation	denotes	inhibited by the transmembrane protein SIGIRR,
T21190	581-625	Positive_regulation	denotes	TAK1 then phosphorylates and activates IKK2,
T21189	1307-1336	Gene_expression	denotes	expression of IRAK1 and TRAF6
T21188	1307-1336	Gene_expression	denotes	expression of IRAK1 and TRAF6
T21187	626-660	Phosphorylation	denotes	which in turn phosphorylates IκBα,
T21186	1470-1496	Binding	denotes	binding to IRAK1 and TRAF6
T21185	1168-1216	Binding	denotes	specific ubiquitin-binding adaptor proteins such
T21184	1633-1652	Positive_regulation	denotes	of NF-κB activation
T21183	410-465	Ubiquitination	denotes	K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1,
T21182	410-465	Ubiquitination	denotes	K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1,
T21181	410-465	Ubiquitination	denotes	K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1,
T21180	931-948	Positive_regulation	denotes	NF-κB activation,
T21179	1036-1132	Regulation	denotes	that control NF-κB activation by targeting specific signalling proteins including RIP1 and TRAF6
T21178	1134-1234	Binding	denotes	to which they are recruited using specific ubiquitin-binding adaptor proteins such as ABIN-1 and p62
T21177	907-992	Regulation	denotes	can negatively regulate NF-κB activation, most probably by competing with other TRAFs
T21176	794-858	Positive_regulation	denotes	to translocate to the nucleus and promote target gene expression
T21175	1296-1336	Negative_regulation	denotes	inhibiting expression of IRAK1 and TRAF6
T21174	1296-1336	Negative_regulation	denotes	inhibiting expression of IRAK1 and TRAF6
T21173	82-101	Localization	denotes	membrane receptors
T21172	1654-1690	Protein	denotes	ABIN, A20-binding inhibitor of NF-κB
T21171	239-244	Protein	denotes	TRADD
T21170	1513-1559	Entity	denotes	of many of these negative regulatory molecules
T21169	1796-1915	Protein	denotes	IRAK, IL-1R-associated kinase; MyD88, myeloid differentiation primary response gene 88; NEMO, NF-κB essential modulator
T21168	1521-1559	Entity	denotes	of these negative regulatory molecules
T21167	1331-1336	Protein	denotes	TRAF6
T21166	575-579	Protein	denotes	TAK1
T21165	1220-1226	Protein	denotes	ABIN-1
T21164	620-625	Protein	denotes	IKK2,
T21163	1168-1216	Protein	denotes	specific ubiquitin-binding adaptor proteins such
T21162	1384-1412	Protein	denotes	by the transmembrane protein
T21161	483-487	Protein	denotes	NEMO
T21160	1917-2008	Protein	denotes	NF, nuclear factor; RANK, receptor activator of NF-κB; RIP1, receptor interacting protein 1
T21159	1654-1659	Protein	denotes	ABIN,
T21158	2010-2017	Protein	denotes	SIGIRR,
T21157	1759-1769	Protein	denotes	IκB kinase
T21156	2099-2122	Protein	denotes	TNF receptor-associated
T21155	1374-1420	Protein	denotes	inhibited by the transmembrane protein SIGIRR,
T21154	1481-1486	Protein	denotes	IRAK1
T21153	1321-1326	Protein	denotes	IRAK1
T21152	1636-1641	Protein	denotes	NF-κB
T21151	1796-1801	Protein	denotes	IRAK,
T21150	321-333	Protein	denotes	RIP1, IRAK1,
T21149	566-570	Protein	denotes	IKK2
T21148	410-420	Entity	denotes	K63-linked
T21147	1884-1889	Protein	denotes	NEMO,
T21146	877-896	Protein	denotes	no ubiquitin ligase
T21145	122-126	Protein	denotes	RANK
T21144	109-114	Protein	denotes	TNFR1
T21143	676-686	Entity	denotes	K48-linked
T21142	2156-2160	Protein	denotes	TNF,
T21141	459-464	Protein	denotes	IRAK1
T21140	1796-1915	Protein	denotes	IRAK, IL-1R-associated kinase; MyD88, myeloid differentiation primary response gene 88; NEMO, NF-κB essential modulator
T21139	327-332	Protein	denotes	IRAK1
T21138	191-245	Protein	denotes	TNF receptor 1-associated death domain protein (TRADD)
T21137	379-392	Protein	denotes	cIAP1, cIAP2)
T21136	1456-1465	Protein	denotes	with TLR4
T21135	2136-2183	Protein	denotes	Toll-like receptor; TNF, tumour necrosis factor
T21134	365-371	Protein	denotes	TRAF2,
T21133	1231-1234	Protein	denotes	p62
T21132	1917-2008	Protein	denotes	NF, nuclear factor; RANK, receptor activator of NF-κB; RIP1, receptor interacting protein 1
T21131	1827-1833	Protein	denotes	MyD88,
T21130	2093-2098	Protein	denotes	TRAF,
T21129	1011-1132	Protein	denotes	deubiquitinating enzymes that control NF-κB activation by targeting specific signalling proteins including RIP1 and TRAF6
T21128	781-784	Protein	denotes	p65
T21127	52-58	Entity	denotes	Ligand
T21126	346-363	Protein	denotes	ubiquitin ligases
T21125	312-341	Protein	denotes	kinases (RIP1, IRAK1, IRAK4),
T21124	346-355	Protein	denotes	ubiquitin
T21123	1802-1806	Protein	denotes	IL-1
T21122	1692-1696	Protein	denotes	cIAP
T21121	1195-1211	Protein	denotes	adaptor proteins
T21120	743-748	Protein	denotes	NF-κB
T21119	2136-2183	Protein	denotes	Toll-like receptor; TNF, tumour necrosis factor
T21118	82-90	Entity	denotes	membrane
T21117	254-310	Protein	denotes	MAL, TIR domain-containing adaptor-inducing IFNβ (TRIF))
T21116	132-136	Protein	denotes	TLR4
T21115	812-823	Entity	denotes	the nucleus
T21114	2010-2085	Protein	denotes	SIGIRR, single-immunoglobulinIL-1 receptor-related; TIR, Toll-like receptor
T21113	2099-2102	Protein	denotes	TNF
T21112	1972-1977	Protein	denotes	RIP1,
T21111	1731-1752	Protein	denotes	CYLD, cylindromatosis
T21110	655-660	Protein	denotes	IκBα,
T21109	365-378	Protein	denotes	TRAF2, TRAF6,
T21108	1789-1794	Protein	denotes	NF-κB
T21107	2010-2085	Protein	denotes	SIGIRR, single-immunoglobulinIL-1 receptor-related; TIR, Toll-like receptor
T21106	931-936	Protein	denotes	NF-κB
T21105	789-792	Protein	denotes	p50
T21104	1049-1065	Protein	denotes	NF-κB activation
T21103	400-408	Protein	denotes	receptor
T21102	764-792	Entity	denotes	a heterodimer of p65 and p50
T21101	116-120	Protein	denotes	CD40
T21100	259-309	Protein	denotes	TIR domain-containing adaptor-inducing IFNβ (TRIF)
T21099	1079-1107	Protein	denotes	specific signalling proteins
T21098	2086-2090	Protein	denotes	IL-1
T21097	1776-1794	Entity	denotes	inhibitor of NF-κB
T21096	1002-1006	Protein	denotes	CYLD
T21095	976-992	Protein	denotes	with other TRAFs
T21094	321-339	Protein	denotes	RIP1, IRAK1, IRAK4
T21093	880-889	Protein	denotes	ubiquitin
T21092	386-391	Protein	denotes	cIAP2
T21091	1796-1915	Protein	denotes	IRAK, IL-1R-associated kinase; MyD88, myeloid differentiation primary response gene 88; NEMO, NF-κB essential modulator
T21090	2062-2066	Protein	denotes	TIR,
T21089	1563-1578	Protein	denotes	NF-κB dependent
T21088	450-454	Protein	denotes	RIP1
T21087	1731-1736	Protein	denotes	CYLD,
T21086	860-906	Protein	denotes	TRAF1, which has no ubiquitin ligase activity,
T21085	1796-1915	Protein	denotes	IRAK, IL-1R-associated kinase; MyD88, myeloid differentiation primary response gene 88; NEMO, NF-κB essential modulator
T21084	581-585	Protein	denotes	TAK1
T21083	0-50	Protein	denotes	Canonical NF-κB signalling and negative regulators
T21082	1698-1716	Entity	denotes	cellular inhibitor
T21081	496-504	Protein	denotes	proteins
T21080	1236-1243	Entity	denotes	miR-146
T21079	304-308	Protein	denotes	TRIF
T21078	1937-1942	Protein	denotes	RANK,
T21077	82-100	Protein	denotes	membrane receptors
T21076	1491-1496	Protein	denotes	TRAF6
T21075	1127-1132	Protein	denotes	TRAF6
T21074	247-252	Protein	denotes	MyD88
T21073	1118-1122	Protein	denotes	RIP1
T21072	443-448	Protein	denotes	TRAFs
T21071	994-997	Protein	denotes	A20
R13883	T21072	T21183	themeOf	TRAFs,"K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1,"
R13884	T21076	T21186	themeOf	TRAF6,binding to IRAK1 and TRAF6
R13885	T21077	T21173	themeOf	membrane receptors,membrane receptors
R13886	T21084	T21190	causeOf	TAK1,"TAK1 then phosphorylates and activates IKK2,"
R13887	T21088	T21181	themeOf	RIP1,"K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1,"
R13888	T21089	T21192	causeOf	NF-κB dependent,The expression of many of these negative regulatory molecules is NF-κB dependent
R13889	T21104	T21179	themeOf	NF-κB activation,that control NF-κB activation by targeting specific signalling proteins including RIP1 and TRAF6
R13890	T21106	T21180	themeOf	NF-κB,"NF-κB activation,"
R13891	T21110	T21187	themeOf	"IκBα,","which in turn phosphorylates IκBα,"
R13892	T21118	T21173	locationOf	membrane,membrane receptors
R13893	T21121	T21185	themeOf	adaptor proteins,specific ubiquitin-binding adaptor proteins such
R13894	T21141	T21182	themeOf	IRAK1,"K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1,"
R13895	T21152	T21184	themeOf	NF-κB,of NF-κB activation
R13896	T21153	T21188	themeOf	IRAK1,expression of IRAK1 and TRAF6
R13897	T21154	T21186	themeOf	IRAK1,binding to IRAK1 and TRAF6
R13898	T21155	T21191	themeOf	"inhibited by the transmembrane protein SIGIRR,","inhibited by the transmembrane protein SIGIRR,"
R13899	T21162	T21191	causeOf	by the transmembrane protein,"inhibited by the transmembrane protein SIGIRR,"
R13900	T21163	T21185	themeOf	specific ubiquitin-binding adaptor proteins such,specific ubiquitin-binding adaptor proteins such
R13901	T21164	T21190	themeOf	"IKK2,","TAK1 then phosphorylates and activates IKK2,"
R13902	T21167	T21189	themeOf	TRAF6,expression of IRAK1 and TRAF6
R13903	T21180	T21177	themeOf	"NF-κB activation,","can negatively regulate NF-κB activation, most probably by competing with other TRAFs"
R13904	T21188	T21174	themeOf	expression of IRAK1 and TRAF6,inhibiting expression of IRAK1 and TRAF6
R13905	T21189	T21175	themeOf	expression of IRAK1 and TRAF6,inhibiting expression of IRAK1 and TRAF6

bionlp-st-ge-2016-test-tees

Id	Subject	Object	Predicate	Lexical cue
T20894	2161-2183	Protein	denotes	tumour necrosis factor
T20893	2156-2159	Protein	denotes	TNF
T20892	2136-2154	Protein	denotes	Toll-like receptor
T20891	2131-2134	Protein	denotes	TLR
T20890	2099-2129	Protein	denotes	TNF receptor-associated factor
T20889	2093-2097	Protein	denotes	TRAF
T20888	2086-2091	Protein	denotes	IL-1R
T20887	2067-2085	Protein	denotes	Toll-like receptor
T20886	2062-2065	Protein	denotes	TIR
T20885	2018-2052	Protein	denotes	single-immunoglobulinIL-1 receptor
T20884	2010-2016	Protein	denotes	SIGIRR
T20883	1978-2008	Protein	denotes	receptor interacting protein 1
T20882	1972-1976	Protein	denotes	RIP1
T20881	1965-1970	Protein	denotes	NF-κB
T20880	1937-1941	Protein	denotes	RANK
T20879	1890-1895	Protein	denotes	NF-κB
T20878	1884-1888	Protein	denotes	NEMO
T20877	1827-1832	Protein	denotes	MyD88
T20876	1802-1807	Protein	denotes	IL-1R
T20875	1796-1800	Protein	denotes	IRAK
T20874	1789-1794	Protein	denotes	NF-κB
T20873	1771-1774	Protein	denotes	IκB
T20872	1759-1769	Protein	denotes	IκB kinase
T20871	1754-1757	Protein	denotes	IKK
T20870	1692-1696	Protein	denotes	cIAP
T20869	1685-1690	Protein	denotes	NF-κB
T20868	1636-1641	Protein	denotes	NF-κB
T20867	1563-1568	Protein	denotes	NF-κB
T20866	1470-1477	Binding	denotes	binding
T20865	1470-1477	Binding	denotes	binding
T20864	1448-1455	Binding	denotes	compete
T20863	1374-1383	Negative_regulation	denotes	inhibited
T20862	1491-1496	Protein	denotes	TRAF6
T20861	1481-1486	Protein	denotes	IRAK1
T20860	1461-1465	Protein	denotes	TLR4
T20859	1347-1350	Protein	denotes	TLR
T20858	1269-1277	Regulation	denotes	regulate
T20857	1269-1277	Regulation	denotes	regulate
T20856	1296-1306	Negative_regulation	denotes	inhibiting
T20855	1296-1306	Negative_regulation	denotes	inhibiting
T20854	1307-1317	Gene_expression	denotes	expression
T20853	1307-1317	Gene_expression	denotes	expression
T20852	1331-1336	Protein	denotes	TRAF6
T20851	1321-1326	Protein	denotes	IRAK1
T20850	1278-1281	Protein	denotes	TLR
T20849	1041-1048	Regulation	denotes	control
T20848	1041-1048	Regulation	denotes	control
T20847	1055-1065	Positive_regulation	denotes	activation
T20846	1231-1234	Protein	denotes	p62
T20845	1127-1132	Protein	denotes	TRAF6
T20844	1118-1122	Protein	denotes	RIP1
T20843	1049-1054	Protein	denotes	NF-κB
T20842	1002-1006	Protein	denotes	CYLD
T20841	994-997	Protein	denotes	A20
T20840	922-930	Regulation	denotes	regulate
T20839	966-975	Binding	denotes	competing
T20838	937-947	Positive_regulation	denotes	activation
T20837	987-992	Protein	denotes	TRAFs
T20836	931-936	Protein	denotes	NF-κB
T20835	880-896	Protein	denotes	ubiquitin ligase
T20834	860-865	Protein	denotes	TRAF1
T20833	797-808	Localization	denotes	translocate
T20832	816-823	Entity	denotes	nucleus
T20831	789-792	Protein	denotes	p50
T20830	781-784	Protein	denotes	p65
T20829	743-748	Protein	denotes	NF-κB
T20828	661-671	Positive_regulation	denotes	triggering
T20827	718-729	Protein_catabolism	denotes	degradation
T20826	640-654	Phosphorylation	denotes	phosphorylates
T20825	640-654	Phosphorylation	denotes	phosphorylates
T20824	610-619	Positive_regulation	denotes	activates
T20823	591-605	Phosphorylation	denotes	phosphorylates
T20822	655-659	Protein	denotes	IκBα
T20821	620-624	Protein	denotes	IKK2
T20820	581-585	Protein	denotes	TAK1
T20819	523-534	Binding	denotes	recruitment
T20818	421-439	Localization	denotes	polyubiquitination
T20817	421-439	Localization	denotes	polyubiquitination
T20816	575-579	Protein	denotes	TAK1
T20815	566-570	Protein	denotes	IKK2
T20814	492-504	Protein	denotes	TAB proteins
T20813	483-487	Protein	denotes	NEMO
T20812	459-464	Protein	denotes	IRAK1
T20811	450-454	Protein	denotes	RIP1
T20810	443-448	Protein	denotes	TRAFs
T20809	386-391	Protein	denotes	cIAP2
T20808	379-384	Protein	denotes	cIAP1
T20807	372-377	Protein	denotes	TRAF6
T20806	365-370	Protein	denotes	TRAF2
T20805	346-363	Protein	denotes	ubiquitin ligases
T20804	334-339	Protein	denotes	IRAK4
T20803	327-332	Protein	denotes	IRAK1
T20802	321-325	Protein	denotes	RIP1
T20801	304-308	Protein	denotes	TRIF
T20800	298-302	Protein	denotes	IFNβ
T20799	259-262	Protein	denotes	TIR
T20798	254-257	Protein	denotes	MAL
T20797	247-252	Protein	denotes	MyD88
T20796	239-244	Protein	denotes	TRADD
T20795	191-237	Protein	denotes	TNF receptor 1-associated death domain protein
T20794	132-136	Protein	denotes	TLR4
T20793	122-126	Protein	denotes	RANK
T20792	116-120	Protein	denotes	CD40
T20791	109-114	Protein	denotes	TNFR1
T20790	10-15	Protein	denotes	NF-κB
R13788	T20855	T20857	causeOf	inhibiting,regulate
R13789	T20856	T20858	causeOf	inhibiting,regulate
R13790	T20859	T20863	themeOf	TLR,inhibited
R13791	T20860	T20864	themeOf	TLR4,compete
R13760	T20811	T20817	themeOf	RIP1,polyubiquitination
R13761	T20812	T20818	themeOf	IRAK1,polyubiquitination
R13762	T20812	T20819	themeOf	IRAK1,recruitment
R13763	T20816	T20819	themeOf	TAK1,recruitment
R13764	T20820	T20823	themeOf	TAK1,phosphorylates
R13765	T20820	T20824	causeOf	TAK1,activates
R13766	T20821	T20824	themeOf	IKK2,activates
R13767	T20821	T20825	themeOf	IKK2,phosphorylates
R13768	T20822	T20826	themeOf	IκBα,phosphorylates
R13769	T20822	T20827	themeOf	IκBα,degradation
R13770	T20827	T20828	themeOf	degradation,triggering
R13771	T20829	T20833	themeOf	NF-κB,translocate
R13772	T20832	T20833	locationOf	nucleus,translocate
R13773	T20836	T20838	themeOf	NF-κB,activation
R13774	T20837	T20839	themeOf	TRAFs,competing
R13775	T20838	T20840	themeOf	activation,regulate
R13776	T20839	T20840	causeOf	competing,regulate
R13777	T20841	T20848	causeOf	A20,control
R13778	T20842	T20849	causeOf	CYLD,control
R13779	T20843	T20847	themeOf	NF-κB,activation
R13780	T20847	T20848	themeOf	activation,control
R13781	T20847	T20849	themeOf	activation,control
R13782	T20850	T20857	themeOf	TLR,regulate
R13783	T20850	T20858	themeOf	TLR,regulate
R13784	T20851	T20853	themeOf	IRAK1,expression
R13785	T20852	T20854	themeOf	TRAF6,expression
R13786	T20853	T20855	themeOf	expression,inhibiting
R13787	T20854	T20856	themeOf	expression,inhibiting
R13792	T20861	T20865	themeOf	IRAK1,binding
R13793	T20862	T20866	themeOf	TRAF6,binding

test3

Id	Subject	Object	Predicate	Lexical cue
T19395	191-237	Protein	denotes	TNF receptor 1-associated death domain protein
T19394	149-160	Binding	denotes	recruitment
T19393	137-144	Positive_regulation	denotes	trigger
T19459	2161-2183	Protein	denotes	tumour necrosis factor
T19458	2156-2159	Protein	denotes	TNF
T19457	2018-2060	Protein	denotes	single-immunoglobulinIL-1 receptor-related
T19456	2010-2016	Protein	denotes	SIGIRR
T19455	1978-2008	Protein	denotes	receptor interacting protein 1
T19454	1972-1976	Protein	denotes	RIP1
T19453	1943-1970	Protein	denotes	receptor activator of NF-κB
T19452	1937-1941	Protein	denotes	RANK
T19451	1890-1915	Protein	denotes	NF-κB essential modulator
T19450	1884-1888	Protein	denotes	NEMO
T19449	1834-1882	Protein	denotes	myeloid differentiation primary response gene 88
T19448	1827-1832	Protein	denotes	MyD88
T19447	1737-1752	Protein	denotes	cylindromatosis
T19446	1731-1735	Protein	denotes	CYLD
T19445	1660-1690	Protein	denotes	A20-binding inhibitor of NF-κB
T19444	1654-1658	Protein	denotes	ABIN
T19443	1491-1496	Protein	denotes	TRAF6
T19442	1481-1486	Protein	denotes	IRAK1
T19441	1470-1477	Binding	denotes	binding
T19440	1461-1465	Protein	denotes	TLR4
T19439	1448-1455	Negative_regulation	denotes	compete
T19438	1413-1419	Protein	denotes	SIGIRR
T19437	1374-1383	Negative_regulation	denotes	inhibited
T19436	1331-1336	Protein	denotes	TRAF6
T19435	1321-1326	Protein	denotes	IRAK1
T19434	1307-1317	Gene_expression	denotes	expression
T19433	1296-1306	Negative_regulation	denotes	inhibiting
T19432	1231-1234	Protein	denotes	p62
T19431	1220-1226	Protein	denotes	ABIN-1
T19430	1187-1194	Binding	denotes	binding
T19429	1152-1161	Binding	denotes	recruited
T19428	1127-1132	Protein	denotes	TRAF6
T19427	1118-1122	Protein	denotes	RIP1
T19426	1002-1006	Protein	denotes	CYLD
T19425	994-997	Protein	denotes	A20
T19424	860-865	Protein	denotes	TRAF1
T19423	816-823	Entity	denotes	nucleus
T19422	797-808	Localization	denotes	translocate
T19421	789-792	Protein	denotes	p50
T19420	781-784	Protein	denotes	p65
T19419	718-729	Protein_catabolism	denotes	degradation
T19418	655-659	Protein	denotes	IκBα
T19417	640-654	Phosphorylation	denotes	phosphorylates
T19416	620-624	Protein	denotes	IKK2
T19415	581-585	Protein	denotes	TAK1
T19414	575-579	Protein	denotes	TAK1
T19413	566-570	Protein	denotes	IKK2
T19412	523-534	Binding	denotes	recruitment
T19411	506-515	Positive_regulation	denotes	resulting
T19410	483-487	Protein	denotes	NEMO
T19409	459-464	Protein	denotes	IRAK1
T19408	450-454	Protein	denotes	RIP1
T19407	386-391	Protein	denotes	cIAP2
T19406	379-384	Protein	denotes	cIAP1
T19405	372-377	Protein	denotes	TRAF6
T19404	365-370	Protein	denotes	TRAF2
T19403	334-339	Protein	denotes	IRAK4
T19402	327-332	Protein	denotes	IRAK1
T19401	321-325	Protein	denotes	RIP1
T19400	304-308	Protein	denotes	TRIF
T19399	259-302	Protein	denotes	TIR domain-containing adaptor-inducing IFNβ
T19398	254-257	Protein	denotes	MAL
T19397	247-252	Protein	denotes	MyD88
T19396	239-244	Protein	denotes	TRADD
T19392	132-136	Protein	denotes	TLR4
T19391	122-126	Protein	denotes	RANK
T19390	116-120	Protein	denotes	CD40
T19389	109-114	Protein	denotes	TNFR1
T19388	59-69	Binding	denotes	engagement
T19387	2161-2183	Protein	denotes	tumour necrosis factor
T19386	2156-2159	Protein	denotes	TNF
T19385	2018-2060	Protein	denotes	single-immunoglobulinIL-1 receptor-related
T19384	2010-2016	Protein	denotes	SIGIRR
T19383	1978-2008	Protein	denotes	receptor interacting protein 1
T19382	1972-1976	Protein	denotes	RIP1
T19381	1943-1970	Protein	denotes	receptor activator of NF-κB
T19380	1937-1941	Protein	denotes	RANK
T19379	1890-1915	Protein	denotes	NF-κB essential modulator
T19378	1884-1888	Protein	denotes	NEMO
T19377	1834-1882	Protein	denotes	myeloid differentiation primary response gene 88
T19376	1827-1832	Protein	denotes	MyD88
T19375	1737-1752	Protein	denotes	cylindromatosis
T19374	1731-1735	Protein	denotes	CYLD
T19373	1660-1690	Protein	denotes	A20-binding inhibitor of NF-κB
T19372	1654-1658	Protein	denotes	ABIN
T19371	1491-1496	Protein	denotes	TRAF6
T19370	1481-1486	Protein	denotes	IRAK1
T19369	1461-1465	Protein	denotes	TLR4
T19368	1413-1419	Protein	denotes	SIGIRR
T19367	1331-1336	Protein	denotes	TRAF6
T19366	1321-1326	Protein	denotes	IRAK1
T19365	1231-1234	Protein	denotes	p62
T19364	1220-1226	Protein	denotes	ABIN-1
T19363	1127-1132	Protein	denotes	TRAF6
T19362	1118-1122	Protein	denotes	RIP1
T19361	1002-1006	Protein	denotes	CYLD
T19360	994-997	Protein	denotes	A20
T19359	860-865	Protein	denotes	TRAF1
T19358	789-792	Protein	denotes	p50
T19357	781-784	Protein	denotes	p65
T19356	655-659	Protein	denotes	IκBα
T19355	620-624	Protein	denotes	IKK2
T19354	581-585	Protein	denotes	TAK1
T19353	575-579	Protein	denotes	TAK1
T19352	566-570	Protein	denotes	IKK2
T19351	483-487	Protein	denotes	NEMO
T19350	459-464	Protein	denotes	IRAK1
T19349	450-454	Protein	denotes	RIP1
T19348	386-391	Protein	denotes	cIAP2
T19347	379-384	Protein	denotes	cIAP1
T19346	372-377	Protein	denotes	TRAF6
T19345	365-370	Protein	denotes	TRAF2
T19344	334-339	Protein	denotes	IRAK4
T19343	327-332	Protein	denotes	IRAK1
T19342	321-325	Protein	denotes	RIP1
T19341	304-308	Protein	denotes	TRIF
T19340	259-302	Protein	denotes	TIR domain-containing adaptor-inducing IFNβ
T19339	254-257	Protein	denotes	MAL
T19338	247-252	Protein	denotes	MyD88
T19337	239-244	Protein	denotes	TRADD
T19336	191-237	Protein	denotes	TNF receptor 1-associated death domain protein
T19335	132-136	Protein	denotes	TLR4
T19334	122-126	Protein	denotes	RANK
T19333	116-120	Protein	denotes	CD40
T19332	109-114	Protein	denotes	TNFR1
R12799	T19388	T19393	causeOf	engagement,trigger
R12800	T19389	T19388	themeOf	TNFR1,engagement
R12801	T19390	T19388	themeOf	CD40,engagement
R12802	T19391	T19388	themeOf	RANK,engagement
R12803	T19392	T19393	causeOf	TLR4,trigger
R12804	T19392	T19388	themeOf	TLR4,engagement
R12805	T19394	T19393	themeOf	recruitment,trigger
R12806	T19396	T19395	equivalentTo	TRADD,TNF receptor 1-associated death domain protein
R12807	T19398	T19394	themeOf	MAL,recruitment
R12808	T19399	T19394	themeOf	TIR domain-containing adaptor-inducing IFNβ,recruitment
R12809	T19400	T19399	equivalentTo	TRIF,TIR domain-containing adaptor-inducing IFNβ
R12810	T19401	T19399	equivalentTo	RIP1,TIR domain-containing adaptor-inducing IFNβ
R12811	T19404	T19403	equivalentTo	TRAF2,IRAK4
R12812	T19404	T19399	equivalentTo	TRAF2,TIR domain-containing adaptor-inducing IFNβ
R12813	T19405	T19394	themeOf	TRAF6,recruitment
R12814	T19406	T19394	themeOf	cIAP1,recruitment
R12815	T19407	T19394	themeOf	cIAP2,recruitment
R12816	T19408	T19412	themeOf	RIP1,recruitment
R12817	T19409	T19412	themeOf	IRAK1,recruitment
R12818	T19410	T19412	themeOf	NEMO,recruitment
R12819	T19412	T19411	themeOf	recruitment,resulting
R12820	T19413	T19412	themeOf	IKK2,recruitment
R12821	T19414	T19412	themeOf	TAK1,recruitment
R12822	T19418	T19417	themeOf	IκBα,phosphorylates
R12823	T19420	T19422	themeOf	p65,translocate
R12824	T19421	T19422	themeOf	p50,translocate
R12825	T19423	T19422	locationOf	nucleus,translocate
R12826	T19425	T19429	themeOf	A20,recruited
R12827	T19426	T19429	themeOf	CYLD,recruited
R12828	T19427	T19430	themeOf	RIP1,binding
R12829	T19427	T19429	themeOf	RIP1,recruited
R12830	T19428	T19429	themeOf	TRAF6,recruited
R12831	T19428	T19430	themeOf	TRAF6,binding
R12832	T19431	T19429	themeOf	ABIN-1,recruited
R12833	T19432	T19429	themeOf	p62,recruited
R12834	T19432	T19430	themeOf	p62,binding
R12835	T19434	T19433	themeOf	expression,inhibiting
R12836	T19435	T19434	themeOf	IRAK1,expression
R12837	T19436	T19434	themeOf	TRAF6,expression
R12838	T19440	T19441	themeOf	TLR4,binding
R12839	T19441	T19439	themeOf	binding,compete
R12840	T19442	T19441	themeOf	IRAK1,binding
R12841	T19443	T19441	themeOf	TRAF6,binding
R12842	T19457	T19452	themeOf	single-immunoglobulinIL-1 receptor-related,RANK

PMC:3218875 / 8540-10724 JSONTXT

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PMC:3218875 / 8540-10724 JSON TXT