PMC:3218875 / 3051-6985 JSON TXT

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testone

Id	Subject	Object	Predicate	Lexical cue
T1679	3096-3105	Positive_regulation	denotes	increased
T1678	2981-2989	Localization	denotes	released
T1677	2944-2952	Localization	denotes	secreted
T1676	1831-1840	Gene_expression	denotes	producing
T1675	1714-1724	Gene_expression	denotes	expression
T1674	1705-1713	Positive_regulation	denotes	Enhanced
T1673	1213-1222	Gene_expression	denotes	expressed
T1672	1156-1163	Binding	denotes	Binding
T1671	1095-1106	Positive_regulation	denotes	upregulated
T1670	916-925	Gene_expression	denotes	expressed
T1669	3708-3718	Protein	denotes	tenascin C
T1668	3698-3706	Protein	denotes	biglycan
T1667	3685-3696	Protein	denotes	fibronectin
T1666	3514-3518	Protein	denotes	TLR4
T1665	3290-3316	Protein	denotes	myeloid-related protein 14
T1664	3260-3285	Protein	denotes	Myeloid-related protein 8
T1663	3197-3202	Protein	denotes	HMGB1
T1662	3132-3137	Protein	denotes	HMGB1
T1661	3087-3092	Protein	denotes	HMGB1
T1660	3048-3060	Protein	denotes	TLR4 ligands
T1659	2903-2922	Protein	denotes	chromatin component
T1658	2876-2881	Protein	denotes	HMGB1
T1657	2829-2874	Protein	denotes	High mobility group box chromosomal protein 1
T1656	1960-1982	Protein	denotes	lymphotoxin β receptor
T1655	1906-1910	Protein	denotes	BAFF
T1654	1785-1789	Protein	denotes	BAFF
T1653	1759-1783	Protein	denotes	B-cell activating factor
T1652	1525-1529	Protein	denotes	CD40
T1651	1251-1254	Protein	denotes	CD4
T1650	1184-1189	Protein	denotes	CD154
T1649	1171-1182	Protein	denotes	CD40 ligand
T1648	1146-1149	Protein	denotes	TNF
T1647	868-894	Protein	denotes	TNF receptor family member
T1646	852-856	Protein	denotes	CD40
T1645	738-742	Protein	denotes	RANK
T1644	642-646	Protein	denotes	RANK
T1643	613-640	Protein	denotes	receptor activator of NF-κB
T1642	399-402	Protein	denotes	TNF
T1641	324-327	Protein	denotes	TNF
T1640	265-268	Protein	denotes	TNF
R1266	T1644	T1643	equivalentTo	RANK,receptor activator of NF-κB
R1267	T1646	T1670	themeOf	CD40,expressed
R1268	T1647	T1670	themeOf	TNF receptor family member,expressed
R1269	T1648	T1671	causeOf	TNF,upregulated
R1270	T1649	T1672	themeOf	CD40 ligand,Binding
R1271	T1649	T1673	themeOf	CD40 ligand,expressed
R1272	T1650	T1649	equivalentTo	CD154,CD40 ligand
R1273	T1653	T1675	themeOf	B-cell activating factor,expression
R1274	T1654	T1653	equivalentTo	BAFF,B-cell activating factor
R1275	T1657	T1659	themeOf	High mobility group box chromosomal protein 1,chromatin component
R1276	T1657	T1678	themeOf	High mobility group box chromosomal protein 1,released
R1277	T1657	T1677	themeOf	High mobility group box chromosomal protein 1,secreted
R1278	T1658	T1657	equivalentTo	HMGB1,High mobility group box chromosomal protein 1
R1279	T1659	T1677	themeOf	chromatin component,secreted
R1280	T1661	T1679	themeOf	HMGB1,increased
R1281	T1670	T1671	themeOf	expressed,upregulated

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T3270	3933-3934	.	denotes	.
T3269	3931-3933	NNP	denotes	RA
T3268	3928-3930	IN	denotes	in
T3267	3917-3927	NN	denotes	expression
T3266	3912-3916	NN	denotes	gene
T3265	3899-3911	JJ	denotes	inflammatory
T3264	3895-3898	CC	denotes	and
T3263	3884-3894	NN	denotes	activation
T3262	3878-3883	JJ	denotes	NF-κB
T3261	3875-3877	TO	denotes	to
T3260	3864-3874	VB	denotes	contribute
T3259	3860-3863	MD	denotes	may
T3258	3853-3859	NN	denotes	tissue
T3257	3847-3852	JJ	denotes	joint
T3256	3838-3846	JJ	denotes	inflamed
T3255	3834-3837	DT	denotes	the
T3254	3831-3833	IN	denotes	in
T3253	3823-3830	NNS	denotes	ligands
T3252	3819-3822	NNP	denotes	TLR
T3251	3811-3818	JJ	denotes	several
T3250	3806-3810	IN	denotes	that
T3249	3798-3805	VBP	denotes	suggest
T3248	3790-3797	NNS	denotes	studies
T3247	3784-3789	DT	denotes	these
T3246	3782-3783	,	denotes	,
T3245	3774-3782	RB	denotes	Together
T3244	3772-3773	.	denotes	.
T3243	3771-3772	-RRB-	denotes	)
T3242	3770-3771	NNP	denotes	]
T3241	3765-3770	CD	denotes	14,15
T3240	3764-3765	NNP	denotes	[
T3239	3761-3763	IN	denotes	in
T3238	3752-3760	VBN	denotes	reviewed
T3237	3751-3752	-LRB-	denotes	(
T3236	3741-3750	NNS	denotes	fragments
T3235	3736-3740	NN	denotes	acid
T3234	3724-3735	JJ	denotes	hyal-uronic
T3233	3720-3723	CC	denotes	and
T3232	3718-3719	,	denotes	,
T3231	3717-3718	NNP	denotes	C
T3230	3708-3716	NN	denotes	tenascin
T3229	3706-3707	,	denotes	,
T3228	3698-3706	NN	denotes	biglycan
T3227	3696-3697	,	denotes	,
T3226	3685-3696	NN	denotes	fibronectin
T3225	3683-3684	,	denotes	,
T3224	3673-3683	NN	denotes	fibrinogen
T3223	3670-3672	IN	denotes	as
T3222	3665-3669	JJ	denotes	such
T3221	3654-3664	NNS	denotes	components
T3220	3647-3653	NN	denotes	matrix
T3219	3633-3646	JJ	denotes	extracellular
T3218	3629-3632	VBP	denotes	are
T3217	3619-3628	NN	denotes	pathology
T3216	3616-3618	NNP	denotes	RA
T3215	3613-3615	IN	denotes	in
T3214	3604-3612	VBN	denotes	involved
T3213	3601-3603	VB	denotes	be
T3212	3597-3600	MD	denotes	may
T3211	3592-3596	WDT	denotes	that
T3210	3584-3591	NNS	denotes	ligands
T3209	3580-3583	NNP	denotes	TLR
T3208	3569-3579	JJ	denotes	endogenous
T3207	3563-3568	JJ	denotes	Other
T3206	3561-3562	.	denotes	.
T3205	3560-3561	NNP	denotes	]
T3204	3555-3560	CD	denotes	17,18
T3203	3554-3555	NNP	denotes	[
T3202	3551-3553	NNP	denotes	RA
T3201	3548-3550	IN	denotes	in
T3200	3535-3547	NN	denotes	inflammation
T3199	3527-3534	NN	denotes	chronic
T3198	3514-3526	JJ	denotes	TLR4-induced
T3197	3511-3513	IN	denotes	in
T3196	3502-3510	VBN	denotes	involved
T3195	3499-3501	VB	denotes	be
T3194	3496-3498	TO	denotes	to
T3193	3486-3495	VBN	denotes	suggested
T3192	3481-3485	VBN	denotes	been
T3191	3476-3480	VBP	denotes	have
T3190	3472-3475	CC	denotes	and
T3189	3470-3471	,	denotes	,
T3188	3465-3470	NN	denotes	fluid
T3187	3456-3464	JJ	denotes	synovial
T3186	3453-3455	NNP	denotes	RA
T3185	3450-3452	IN	denotes	in
T3184	3442-3449	JJ	denotes	present
T3183	3431-3441	RB	denotes	abundantly
T3182	3426-3430	RB	denotes	also
T3181	3422-3425	VBP	denotes	are
T3180	3420-3421	,	denotes	,
T3179	3412-3420	NNS	denotes	proteins
T3178	3396-3411	JJ	denotes	calcium-binding
T3177	3393-3395	IN	denotes	of
T3176	3386-3392	NN	denotes	family
T3175	3381-3385	NNP	denotes	S100
T3174	3377-3380	DT	denotes	the
T3173	3374-3376	TO	denotes	to
T3172	3364-3373	VBG	denotes	belonging
T3171	3354-3363	NNS	denotes	molecules
T3170	3346-3353	NN	denotes	pattern
T3169	3336-3345	JJ	denotes	molecular
T3168	3318-3335	JJ	denotes	damage-associated
T3167	3316-3317	,	denotes	,
T3166	3314-3316	CD	denotes	14
T3165	3306-3313	NN	denotes	protein
T3164	3290-3305	JJ	denotes	myeloid-related
T3163	3286-3289	CC	denotes	and
T3162	3284-3285	CD	denotes	8
T3161	3276-3283	NN	denotes	protein
T3160	3260-3275	JJ	denotes	Myeloid-related
T3159	3258-3259	.	denotes	.
T3158	3257-3258	NNP	denotes	]
T3157	3255-3257	CD	denotes	16
T3156	3254-3255	NNP	denotes	[
T3155	3249-3253	NNS	denotes	mice
T3154	3246-3248	IN	denotes	in
T3153	3236-3245	NNS	denotes	arthritis
T3152	3219-3235	JJ	denotes	collagen-induced
T3151	3211-3218	IN	denotes	against
T3150	3203-3210	VBP	denotes	protect
T3149	3197-3202	NNP	denotes	HMGB1
T3148	3194-3196	IN	denotes	of
T3147	3187-3193	NN	denotes	domain
T3146	3182-3186	NNP	denotes	BoxA
T3145	3169-3181	JJ	denotes	antagonistic
T3144	3165-3168	DT	denotes	the
T3143	3162-3164	CC	denotes	or
T3142	3151-3161	NNS	denotes	antibodies
T3141	3138-3150	VBG	denotes	neutralising
T3140	3132-3137	NNP	denotes	HMGB1
T3139	3128-3131	CC	denotes	and
T3138	3121-3127	NN	denotes	tissue
T3137	3112-3120	JJ	denotes	synovial
T3136	3109-3111	NNP	denotes	RA
T3135	3106-3108	IN	denotes	in
T3134	3096-3105	VBN	denotes	increased
T3133	3093-3095	VBZ	denotes	is
T3132	3087-3092	CD	denotes	HMGB1
T3131	3085-3086	.	denotes	.
T3130	3076-3085	NN	denotes	pathology
T3129	3073-3075	NNP	denotes	RA
T3128	3070-3072	IN	denotes	in
T3119	3012-3015	CD	denotes	one
T3118	3009-3011	VBZ	denotes	is
T3117	3007-3008	,	denotes	,
T3116	3002-3007	NNS	denotes	cells
T3115	2993-3001	JJ	denotes	necrotic
T3114	2990-2992	IN	denotes	by
T3113	2981-2989	VBN	denotes	released
T3112	2971-2980	RB	denotes	passively
T3111	2968-2970	CC	denotes	or
T3110	2956-2967	NNS	denotes	macrophages
T3109	2953-2955	IN	denotes	by
T3108	2944-2952	VBN	denotes	secreted
T3107	2935-2943	RB	denotes	actively
T3106	2932-2934	VB	denotes	be
T3105	2928-2931	MD	denotes	can
T3104	2923-2927	WDT	denotes	that
T3103	2913-2922	NN	denotes	component
T3102	2903-2912	NN	denotes	chromatin
T3101	2893-2902	VBN	denotes	conserved
T3100	2886-2892	RB	denotes	highly
T3099	2884-2885	DT	denotes	a
T3098	2882-2883	,	denotes	,
T3097	2881-2882	-RRB-	denotes	)
T3096	2876-2881	CD	denotes	HMGB1
T3095	2875-2876	-LRB-	denotes	(
T3094	2873-2874	CD	denotes	1
T3093	2865-2872	NN	denotes	protein
T3092	2853-2864	JJ	denotes	chromosomal
T3091	2849-2852	NN	denotes	box
T3090	2843-2848	NN	denotes	group
T3089	2834-2842	NN	denotes	mobility
T3088	2829-2833	NNP	denotes	High
T3087	2827-2828	.	denotes	.
T3086	2820-2827	NN	denotes	disease
T3085	2816-2819	DT	denotes	the
T3084	2813-2815	IN	denotes	of
T3083	2800-2812	NN	denotes	pathogenesis
T3082	2796-2799	DT	denotes	the
T3081	2793-2795	IN	denotes	in
T3080	2783-2792	JJ	denotes	important
T3079	2777-2782	VBG	denotes	being
T3078	2774-2776	IN	denotes	as
T3077	2761-2773	NN	denotes	inflammation
T3076	2747-2760	JJ	denotes	TLR-dependent
T3075	2738-2746	VB	denotes	identify
T3074	2730-2737	RB	denotes	clearly
T3073	2719-2729	VBG	denotes	signalling
T3072	2715-2718	NNP	denotes	TLR
T3071	2709-2714	VB	denotes	block
T3070	2706-2708	TO	denotes	to
T3069	2695-2705	NNS	denotes	strategies
T3068	2692-2694	CC	denotes	or
T3067	2687-2691	NNS	denotes	mice
T3066	2678-2686	NN	denotes	knockout
T3065	2674-2677	NNP	denotes	TLR
T3064	2668-2673	VBG	denotes	using
T3063	2661-2667	NNS	denotes	models
T3062	2654-2660	NN	denotes	animal
T3061	2652-2653	,	denotes	,
T3060	2644-2652	RB	denotes	Moreover
T3059	2642-2643	.	denotes	.
T3058	2634-2642	NNS	denotes	patients
T3057	2631-2633	NNP	denotes	RA
T3056	2628-2630	IN	denotes	of
T3055	2621-2627	NNS	denotes	joints
T3054	2612-2620	JJ	denotes	inflamed
T3053	2608-2611	DT	denotes	the
T3052	2601-2607	IN	denotes	within
T3051	2593-2600	JJ	denotes	present
T3050	2589-2592	VBP	denotes	are
T3049	2581-2588	NNS	denotes	ligands
T3048	2570-2580	JJ	denotes	endogenous
T3047	2562-2569	JJ	denotes	various
T3046	2558-2561	CC	denotes	and
T3045	2550-2557	NNS	denotes	tissues
T3044	2541-2549	JJ	denotes	synovial
T3043	2538-2540	NNP	denotes	RA
T3042	2535-2537	IN	denotes	in
T3041	2525-2534	VBN	denotes	expressed
T3040	2521-2524	VBP	denotes	are
T3039	2516-2520	NNS	denotes	TLRs
T3038	2514-2515	.	denotes	.
T3037	2513-2514	-RRB-	denotes	)
T3036	2512-2513	NNP	denotes	]
T3035	2507-2512	CD	denotes	14,15
T3034	2506-2507	NNP	denotes	[
T3033	2503-2505	IN	denotes	in
T3032	2494-2502	VBN	denotes	reviewed
T3031	2493-2494	-LRB-	denotes	(
T3030	2480-2492	NN	denotes	inflammation
T3029	2472-2479	JJ	denotes	sterile
T3028	2462-2471	JJ	denotes	so-called
T3027	2453-2461	VBG	denotes	inducing
T3026	2448-2452	NNS	denotes	TLRs
T3025	2445-2447	IN	denotes	of
T3024	2434-2444	NNS	denotes	activators
T3023	2424-2433	NN	denotes	candidate
T3022	2421-2423	IN	denotes	as
T3021	2412-2420	VBN	denotes	reported
T3020	2407-2411	VBN	denotes	been
T3019	2402-2406	VB	denotes	have
T3018	2400-2401	:	denotes	-
T3017	2394-2399	NNS	denotes	cells
T3016	2390-2393	CC	denotes	and
T3015	2382-2389	NNS	denotes	tissues
T3014	2377-2381	NN	denotes	host
T3013	2372-2376	IN	denotes	from
T3012	2364-2371	VBN	denotes	derived
T3011	2355-2363	NNS	denotes	proteins
T3010	2352-2354	IN	denotes	of
T3009	2346-2351	NN	denotes	group
T3008	2344-2345	DT	denotes	a
T3007	2342-2343	:	denotes	-
T3006	2334-2341	NNS	denotes	ligands
T3005	2323-2333	JJ	denotes	endogenous
T3004	2320-2322	IN	denotes	of
T3003	2313-2319	NN	denotes	number
T3002	2302-2312	VBG	denotes	increasing
T3001	2299-2301	DT	denotes	an
T3000	2297-2298	,	denotes	,
T2999	2290-2297	NNS	denotes	ligands
T2998	2280-2289	JJ	denotes	microbial
T2997	2277-2279	TO	denotes	to
T2996	2268-2276	NN	denotes	addition
T2995	2265-2267	IN	denotes	In
T2994	2263-2264	.	denotes	.
T2993	2261-2263	NNP	denotes	RA
T2992	2258-2260	IN	denotes	in
T2991	2245-2257	NN	denotes	inflammation
T2990	2229-2244	JJ	denotes	NF-κB-dependent
T2989	2220-2228	VBG	denotes	inducing
T2988	2216-2219	IN	denotes	for
T2987	2205-2215	NNS	denotes	candidates
T2986	2195-2204	JJ	denotes	potential
T2985	2191-2194	VBP	denotes	are
T2984	2187-2190	CC	denotes	and
T2983	2178-2186	NNS	denotes	diseases
T2982	2167-2177	JJ	denotes	autoimmune
T2981	2164-2166	IN	denotes	of
T2980	2156-2163	NN	denotes	variety
T2979	2154-2155	DT	denotes	a
T2978	2151-2153	IN	denotes	in
T2977	2140-2150	VBN	denotes	implicated
T2976	2135-2139	VBN	denotes	been
T2975	2130-2134	VBP	denotes	have
T2974	2128-2129	-RRB-	denotes	)
T2973	2124-2128	NNS	denotes	TLRs
T2972	2123-2124	-LRB-	denotes	(
T2971	2113-2122	NNS	denotes	receptors
T2970	2103-2112	JJ	denotes	Toll-like
T2969	2101-2102	.	denotes	.
T2968	2100-2101	NNP	denotes	]
T2967	2098-2100	CD	denotes	13
T2966	2097-2098	NNP	denotes	[
T2965	2094-2096	NNP	denotes	RA
T2964	2084-2093	VBG	denotes	including
T2963	2071-2083	NN	denotes	inflammation
T2962	2063-2070	JJ	denotes	chronic
T2961	2060-2062	IN	denotes	of
T2960	2054-2059	NNS	denotes	sites
T2959	2051-2053	IN	denotes	at
T2958	2041-2050	NN	denotes	formation
T2957	2035-2040	NN	denotes	organ
T2956	2026-2034	JJ	denotes	lymphoid
T2955	2017-2025	JJ	denotes	tertiary
T2954	2014-2016	IN	denotes	in
T2953	2003-2013	VBN	denotes	implicated
T2952	1998-2002	VBN	denotes	been
T2951	1994-1997	VBZ	denotes	has
T2950	1983-1993	NN	denotes	signalling
T2949	1974-1982	NN	denotes	receptor
T2948	1972-1973	NN	denotes	β
T2947	1960-1971	NN	denotes	lymphotoxin
T2946	1958-1959	,	denotes	,
T2945	1951-1958	RB	denotes	Finally
T2944	1949-1950	.	denotes	.
T2943	1948-1949	NNP	denotes	]
T2942	1946-1948	CD	denotes	13
T2941	1945-1946	NNP	denotes	[
T2940	1942-1944	NNP	denotes	RA
T2939	1934-1941	VB	denotes	counter
T2938	1931-1933	TO	denotes	to
T2937	1921-1930	VBN	denotes	developed
T2936	1916-1920	VBN	denotes	been
T2935	1911-1915	VBP	denotes	have
T2934	1906-1910	NNP	denotes	BAFF
T2933	1903-1905	IN	denotes	of
T2932	1891-1902	NNS	denotes	antagonists
T2931	1887-1890	CC	denotes	and
T2930	1885-1886	,	denotes	,
T2929	1883-1885	NNP	denotes	RA
T2928	1879-1882	IN	denotes	for
T2927	1864-1878	JJ	denotes	characteristic
T2926	1859-1863	RB	denotes	also
T2925	1856-1858	VBZ	denotes	is
T2924	1854-1855	,	denotes	,
T2923	1843-1854	NNS	denotes	lymphocytes
T2922	1841-1842	NNP	denotes	B
T2921	1831-1840	VBG	denotes	producing
T2920	1829-1830	:	denotes	-
T2919	1817-1829	NN	denotes	autoantibody
T2918	1814-1816	IN	denotes	of
T2917	1805-1813	NN	denotes	survival
T2916	1801-1804	DT	denotes	the
T2915	1792-1800	VBG	denotes	allowing
T2914	1790-1791	,	denotes	,
T2913	1789-1790	-RRB-	denotes	)
T2912	1785-1789	NNP	denotes	BAFF
T2911	1784-1785	-LRB-	denotes	(
T2910	1777-1783	NN	denotes	factor
T2909	1766-1776	VBG	denotes	activating
T2908	1759-1765	NNP	denotes	B-cell
T2907	1752-1758	NN	denotes	member
T2906	1745-1751	NN	denotes	family
T2905	1736-1744	NN	denotes	receptor
T2904	1732-1735	NNP	denotes	TNF
T2892	1665-1675	NNS	denotes	antibodies
T2891	1654-1664	JJ	denotes	pathogenic
T2890	1650-1653	CC	denotes	and
T2889	1638-1649	VBN	denotes	established
T2888	1635-1637	VBZ	denotes	is
T2887	1627-1634	NN	denotes	disease
T2886	1622-1626	RB	denotes	once
T2885	1613-1621	VBN	denotes	required
T2884	1609-1612	RB	denotes	not
T2883	1605-1608	VBP	denotes	are
T2882	1601-1604	CC	denotes	but
T2881	1599-1600	,	denotes	,
T2880	1590-1599	NN	denotes	induction
T2879	1580-1589	NN	denotes	arthritis
T2878	1577-1579	IN	denotes	of
T2877	1570-1576	NNS	denotes	stages
T2876	1562-1569	JJ	denotes	initial
T2875	1558-1561	DT	denotes	the
T2874	1555-1557	IN	denotes	at
T2873	1545-1554	JJ	denotes	important
T2872	1542-1544	VB	denotes	be
T2871	1538-1541	MD	denotes	may
T2870	1530-1537	NNS	denotes	signals
T2869	1525-1529	NNP	denotes	CD40
T2868	1520-1524	WDT	denotes	that
T2867	1509-1519	NN	denotes	conclusion
T2866	1505-1508	DT	denotes	the
T2865	1502-1504	TO	denotes	to
T2864	1498-1501	VBD	denotes	led
T2863	1487-1497	NNS	denotes	antibodies
T2862	1476-1486	JJ	denotes	anti-CD154
T2861	1473-1475	CC	denotes	or
T2860	1463-1472	JJ	denotes	anti-CD40
T2859	1450-1462	JJ	denotes	antagonistic
T2858	1445-1449	IN	denotes	with
T2857	1437-1444	NNS	denotes	studies
T2856	1435-1436	,	denotes	,
T2855	1428-1435	RB	denotes	However
T2854	1426-1427	.	denotes	.
T2853	1415-1426	NN	denotes	destruction
T2852	1409-1414	JJ	denotes	joint
T2851	1406-1408	TO	denotes	to
T2850	1394-1405	VBZ	denotes	contributes
T2849	1388-1393	WDT	denotes	which
T2848	1386-1387	,	denotes	,
T2847	1376-1386	NNS	denotes	chemokines
T2846	1372-1375	CC	denotes	and
T2845	1362-1371	NNS	denotes	cytokines
T2844	1346-1361	JJ	denotes	proinflammatory
T2843	1343-1345	IN	denotes	of
T2842	1333-1342	NN	denotes	secretion
T2841	1329-1332	CC	denotes	and
T2840	1315-1328	NN	denotes	proliferation
T2839	1304-1314	NN	denotes	fibroblast
T2838	1301-1303	IN	denotes	in
T2837	1291-1300	VBG	denotes	resulting
T2836	1280-1290	NN	denotes	activation
T2835	1274-1279	NNP	denotes	NF-κB
T2834	1265-1273	VBZ	denotes	triggers
T2833	1263-1264	,	denotes	,
T2832	1258-1263	NNS	denotes	cells
T2831	1256-1257	NNP	denotes	T
T2830	1254-1255	CD	denotes	+
T2829	1251-1254	NNP	denotes	CD4
T2828	1241-1250	VBN	denotes	activated
T2827	1238-1240	IN	denotes	of
T2826	1230-1237	NN	denotes	surface
T2825	1226-1229	DT	denotes	the
T2824	1223-1225	IN	denotes	on
T2823	1213-1222	VBN	denotes	expressed
T2822	1201-1212	RB	denotes	transiently
T2821	1198-1200	VBZ	denotes	is
T2820	1192-1197	WDT	denotes	which
T2819	1190-1191	,	denotes	,
T2818	1189-1190	-RRB-	denotes	)
T2817	1184-1189	NNP	denotes	CD154
T2816	1183-1184	-LRB-	denotes	(
T2815	1176-1182	NN	denotes	ligand
T2814	1171-1175	NNP	denotes	CD40
T2813	1167-1170	DT	denotes	the
T2812	1164-1166	IN	denotes	of
T2811	1156-1163	VBG	denotes	Binding
T2810	1154-1155	.	denotes	.
T2809	1153-1154	NNP	denotes	]
T2808	1151-1153	CD	denotes	10
T2807	1150-1151	NNP	denotes	[
T2806	1146-1149	NNP	denotes	TNF
T2805	1136-1145	VBG	denotes	including
T2804	1126-1135	NNS	denotes	cytokines
T2803	1110-1125	JJ	denotes	proinflammatory
T2802	1107-1109	IN	denotes	by
T2801	1095-1106	VBN	denotes	upregulated
T2800	1092-1094	VB	denotes	be
T2799	1088-1091	MD	denotes	can
T2798	1084-1087	CC	denotes	and
T2797	1082-1083	,	denotes	,
T2796	1077-1082	NNS	denotes	cells
T2795	1067-1076	JJ	denotes	dendritic
T2794	1063-1066	CC	denotes	and
T2793	1061-1062	,	denotes	,
T3127	3061-3069	VBN	denotes	involved
T3126	3053-3060	NNS	denotes	ligands
T3125	3048-3052	CD	denotes	TLR4
T3124	3037-3047	JJ	denotes	endogenous
T3123	3028-3036	JJ	denotes	putative
T3122	3023-3027	RBS	denotes	most
T3121	3019-3022	DT	denotes	the
T3120	3016-3018	IN	denotes	of
T2792	1050-1061	NNS	denotes	macrophages
T2791	1048-1049	,	denotes	,
T2790	1043-1048	NNS	denotes	cells
T2789	1041-1042	NNP	denotes	B
T2788	1039-1040	,	denotes	,
T2787	1034-1039	NNS	denotes	cells
T2786	1025-1033	JJ	denotes	synovial
T2785	1022-1024	NNP	denotes	RA
T2784	1018-1021	CC	denotes	and
T2783	1009-1017	NNS	denotes	patients
T2782	1006-1008	NNP	denotes	RA
T2781	1002-1005	CC	denotes	and
T2780	995-1001	JJ	denotes	normal
T2779	990-994	IN	denotes	from
T2778	978-989	NNS	denotes	fibroblasts
T2777	971-977	NN	denotes	muscle
T2776	964-970	JJ	denotes	smooth
T2775	954-963	VBG	denotes	including
T2774	952-953	,	denotes	,
T2773	947-952	NNS	denotes	types
T2772	942-946	NN	denotes	cell
T2771	939-941	IN	denotes	of
T2770	931-938	NN	denotes	variety
T2769	929-930	DT	denotes	a
T2768	926-928	IN	denotes	on
T2767	916-925	VBN	denotes	expressed
T2766	903-915	RB	denotes	functionally
T2765	900-902	VBZ	denotes	is
T2764	895-899	WDT	denotes	that
T2763	888-894	NN	denotes	member
T2762	881-887	NN	denotes	family
T2761	872-880	NN	denotes	receptor
T2760	868-871	NN	denotes	TNF
T2759	860-867	DT	denotes	another
T2758	857-859	VBZ	denotes	is
T2757	852-856	CD	denotes	CD40
T2756	850-851	.	denotes	.
T2755	849-850	NNP	denotes	]
T2754	848-849	CD	denotes	7
T2753	847-848	NN	denotes	[
T2752	842-846	NN	denotes	loss
T2751	837-841	NN	denotes	bone
T2750	832-836	IN	denotes	with
T2749	821-831	VBN	denotes	associated
T2748	812-820	NNS	denotes	diseases
T2747	806-811	JJ	denotes	other
T2746	802-805	CC	denotes	and
T2745	792-801	NN	denotes	pathology
T2744	789-791	NNP	denotes	RA
T2743	786-788	IN	denotes	in
T2742	777-785	VBN	denotes	involved
T2741	774-776	VB	denotes	be
T2740	771-773	TO	denotes	to
T2739	764-770	JJ	denotes	likely
T2738	760-763	VBP	denotes	are
T2737	749-759	VBG	denotes	signalling
T2736	738-748	NN	denotes	RANK-NF-κB
T2735	731-737	JJ	denotes	proper
T2734	728-730	IN	denotes	in
T2733	720-727	NNS	denotes	defects
T2732	716-719	CC	denotes	and
T2731	714-715	,	denotes	,
T2730	696-714	NN	denotes	osteoclastogenesis
T2729	692-695	IN	denotes	for
T2728	682-691	JJ	denotes	important
T2727	679-681	VBZ	denotes	is
T2726	677-678	,	denotes	,
T2725	671-677	NN	denotes	member
T2724	664-670	NN	denotes	family
T2723	655-663	NN	denotes	receptor
T2722	651-654	NNP	denotes	TNF
T2721	649-650	DT	denotes	a
T2720	647-648	,	denotes	,
T2719	646-647	-RRB-	denotes	)
T2718	642-646	NNP	denotes	RANK
T2717	641-642	-LRB-	denotes	(
T2716	635-640	NNP	denotes	NF-κB
T2715	632-634	IN	denotes	of
T2714	622-631	NN	denotes	activator
T2713	613-621	NN	denotes	receptor
T2712	610-612	IN	denotes	by
T2711	599-609	NN	denotes	activation
T2710	593-598	JJ	denotes	NF-κB
T2709	591-592	.	denotes	.
T2708	590-591	-RRB-	denotes	)
T2707	589-590	NNP	denotes	]
T2706	588-589	CD	denotes	3
T2705	587-588	NNP	denotes	[
T2704	584-586	IN	denotes	in
T2703	575-583	VBN	denotes	reviewed
T2702	574-575	-LRB-	denotes	(
T2701	571-573	NNP	denotes	RA
T2700	568-570	IN	denotes	in
T2699	557-567	NNS	denotes	activities
T2698	540-556	JJ	denotes	pro-inflammatory
T2697	534-539	PRP$	denotes	their
T2696	531-533	IN	denotes	of
T2695	526-530	JJS	denotes	most
T2694	517-525	VBZ	denotes	mediates
T2693	507-516	NNS	denotes	cytokines
T2692	501-506	DT	denotes	these
T2691	498-500	IN	denotes	by
T2690	487-497	NN	denotes	activation
T2689	481-486	JJ	denotes	NF-κB
T2688	476-480	DT	denotes	that
T2687	467-475	VBN	denotes	expected
T2686	464-466	VB	denotes	be
T2685	460-463	MD	denotes	can
T2684	457-459	PRP	denotes	it
T2683	453-456	CC	denotes	and
T2682	447-452	NN	denotes	NF-κB
T2681	444-446	IN	denotes	of
T2680	433-443	NNS	denotes	activators
T2679	426-432	JJ	denotes	potent
T2678	421-425	RB	denotes	very
T2677	416-420	DT	denotes	both
T2633	199-201	IN	denotes	in
T2632	193-198	NN	denotes	NF-κB
T2631	184-192	VBP	denotes	activate
T2630	179-183	IN	denotes	that
T2629	170-178	VBZ	denotes	triggers
T2628	160-169	JJ	denotes	molecular
T2627	156-159	DT	denotes	the
T2626	153-155	IN	denotes	of
T2625	138-152	NN	denotes	identification
T2624	134-137	DT	denotes	the
T2623	129-133	IN	denotes	with
T2622	123-128	NNS	denotes	deals
T2621	114-122	NN	denotes	research
T2620	109-113	JJ	denotes	much
T2619	107-108	,	denotes	,
T2618	105-107	NNP	denotes	RA
T2617	102-104	IN	denotes	in
T2616	89-101	NN	denotes	inflammation
T2615	86-88	IN	denotes	of
T2614	78-85	NN	denotes	process
T2613	74-77	DT	denotes	the
T2612	71-73	TO	denotes	to
T2611	63-70	JJ	denotes	central
T2610	60-62	VBZ	denotes	is
T2609	54-59	NNP	denotes	NF-κB
T2608	48-53	IN	denotes	Since
T2903	1728-1731	DT	denotes	the
T2902	1725-1727	IN	denotes	of
T2901	1714-1724	NN	denotes	expression
T2900	1705-1713	VBN	denotes	Enhanced
T2899	1703-1704	.	denotes	.
T2898	1702-1703	NNP	denotes	]
T2897	1697-1702	CD	denotes	11,12
T2896	1696-1697	NNP	denotes	[
T2895	1688-1695	JJ	denotes	present
T2894	1680-1687	RB	denotes	already
T2893	1676-1679	VBP	denotes	are
T2676	412-415	VBP	denotes	are
T2675	407-411	NNP	denotes	IL-1
T2674	403-406	CC	denotes	and
T2673	399-402	NNP	denotes	TNF
T2672	397-398	.	denotes	.
T2671	396-397	-RRB-	denotes	)
T2670	395-396	NNP	denotes	]
T2669	394-395	CD	denotes	9
T2668	393-394	NNP	denotes	[
T2667	390-392	IN	denotes	in
T2666	381-389	VBN	denotes	reviewed
T2665	380-381	-LRB-	denotes	(
T2664	377-379	NNP	denotes	RA
T2663	370-376	JJ	denotes	severe
T2662	366-369	IN	denotes	for
T2661	356-365	NN	denotes	treatment
T2660	346-355	JJ	denotes	effective
T2659	343-345	DT	denotes	an
T2658	340-342	VBZ	denotes	is
T2657	328-339	NNS	denotes	antagonists
T2656	324-327	NNP	denotes	TNF
T2655	321-323	IN	denotes	of
T2654	306-320	NN	denotes	administration
T2653	302-305	CC	denotes	and
T2652	300-301	,	denotes	,
T2651	296-300	NN	denotes	role
T2650	286-295	JJ	denotes	important
T2649	283-285	DT	denotes	an
T2648	278-282	VBP	denotes	play
T2647	273-277	NNP	denotes	IL-1
T2646	269-272	CC	denotes	and
T2645	265-268	NNP	denotes	TNF
T2644	262-264	IN	denotes	as
T2643	257-261	JJ	denotes	such
T2642	247-256	NNS	denotes	cytokines
T2641	231-246	JJ	denotes	proinflammatory
T2640	226-230	IN	denotes	that
T2639	217-225	VBN	denotes	accepted
T2638	212-216	RB	denotes	well
T2637	209-211	VBZ	denotes	is
T2636	206-208	PRP	denotes	It
T2635	204-205	.	denotes	.
T2634	202-204	NNP	denotes	RA
R1987	T2608	T2610	mark	Since,is
R1988	T2609	T2610	nsubj	NF-κB,is
R1989	T2610	T2622	advcl	is,deals
R1990	T2611	T2610	acomp	central,is
R1991	T2612	T2611	prep	to,central
R1992	T2613	T2614	det	the,process
R1993	T2614	T2612	pobj	process,to
R1994	T2615	T2614	prep	of,process
R1995	T2616	T2615	pobj	inflammation,of
R1996	T2617	T2614	prep	in,process
R1997	T2618	T2617	pobj	RA,in
R1998	T2619	T2622	punct	",",deals
R1999	T2620	T2622	amod	much,deals
R2000	T2621	T2622	compound	research,deals
R2001	T2622	T2622	ROOT	deals,deals
R2002	T2623	T2622	prep	with,deals
R2003	T2624	T2625	det	the,identification
R2004	T2625	T2623	pobj	identification,with
R2005	T2626	T2625	prep	of,identification
R2006	T2627	T2628	det	the,molecular
R2007	T2628	T2626	pobj	molecular,of
R2008	T2629	T2622	conj	triggers,deals
R2009	T2630	T2631	nsubj	that,activate
R2010	T2631	T2629	ccomp	activate,triggers
R2011	T2632	T2631	dobj	NF-κB,activate
R2012	T2633	T2631	prep	in,activate
R2013	T2634	T2633	pobj	RA,in
R2014	T2635	T2629	punct	.,triggers
R2015	T2636	T2639	nsubjpass	It,accepted
R2016	T2637	T2639	auxpass	is,accepted
R2017	T2638	T2639	advmod	well,accepted
R2018	T2639	T2639	ROOT	accepted,accepted
R2019	T2640	T2648	mark	that,play
R2020	T2641	T2642	amod	proinflammatory,cytokines
R2021	T2642	T2648	nsubj	cytokines,play
R2022	T2643	T2644	amod	such,as
R2023	T2644	T2642	prep	as,cytokines
R2024	T2645	T2644	pobj	TNF,as
R2025	T2646	T2645	cc	and,TNF
R2026	T2647	T2645	conj	IL-1,TNF
R2027	T2648	T2639	ccomp	play,accepted
R2028	T2649	T2651	det	an,role
R2029	T2650	T2651	amod	important,role
R2030	T2651	T2648	dobj	role,play
R2031	T2652	T2648	punct	",",play
R2032	T2653	T2648	cc	and,play
R2033	T2654	T2648	conj	administration,play
R2034	T2655	T2654	prep	of,administration
R2035	T2656	T2657	compound	TNF,antagonists
R2036	T2657	T2655	pobj	antagonists,of
R2037	T2658	T2639	conj	is,accepted
R2038	T2659	T2661	det	an,treatment
R2039	T2660	T2661	amod	effective,treatment
R2040	T2661	T2658	attr	treatment,is
R2041	T2662	T2661	prep	for,treatment
R2042	T2663	T2664	amod	severe,RA
R2043	T2664	T2662	pobj	RA,for
R2044	T2665	T2666	punct	(,reviewed
R2045	T2666	T2664	parataxis	reviewed,RA
R2046	T2667	T2666	prep	in,reviewed
R2047	T2668	T2667	pobj	[,in
R2048	T2669	T2670	nummod	9,]
R2049	T2670	T2668	appos	],[
R2050	T2671	T2668	punct	),[
R2051	T2672	T2639	punct	.,accepted
R2052	T2673	T2676	nsubj	TNF,are
R2053	T2674	T2673	cc	and,TNF
R2054	T2675	T2673	conj	IL-1,TNF
R2055	T2676	T2676	ROOT	are,are
R2056	T2677	T2676	dep	both,are
R2057	T2678	T2679	advmod	very,potent
R2058	T2679	T2680	amod	potent,activators
R2059	T2680	T2676	attr	activators,are
R2060	T2681	T2680	prep	of,activators
R2061	T2682	T2681	pobj	NF-κB,of
R2062	T2683	T2676	cc	and,are
R2063	T2684	T2687	nsubjpass	it,expected
R2064	T2685	T2687	aux	can,expected
R2065	T2686	T2687	auxpass	be,expected
R2066	T2687	T2676	conj	expected,are
R2067	T2688	T2690	det	that,activation
R2068	T2689	T2690	amod	NF-κB,activation
R2069	T2690	T2694	nsubj	activation,mediates
R2070	T2691	T2690	prep	by,activation
R2071	T2692	T2693	det	these,cytokines
R2072	T2693	T2691	pobj	cytokines,by
R2073	T2694	T2676	conj	mediates,are
R2074	T2695	T2694	dobj	most,mediates
R2075	T2696	T2695	prep	of,most
R2076	T2697	T2699	poss	their,activities
R2077	T2698	T2699	amod	pro-inflammatory,activities
R2078	T2699	T2696	pobj	activities,of
R2079	T2700	T2699	prep	in,activities
R2080	T2701	T2700	pobj	RA,in
R2081	T2702	T2701	punct	(,RA
R2082	T2703	T2694	advcl	reviewed,mediates
R2083	T2704	T2703	prep	in,reviewed
R2084	T2705	T2704	pobj	[,in
R2085	T2706	T2707	nummod	3,]
R2086	T2707	T2705	appos	],[
R2087	T2708	T2705	punct	),[
R2088	T2709	T2694	punct	.,mediates
R2089	T2710	T2711	amod	NF-κB,activation
R2090	T2711	T2727	nsubj	activation,is
R2091	T2712	T2711	prep	by,activation
R2092	T2713	T2712	pobj	receptor,by
R2093	T2714	T2711	conj	activator,activation
R2094	T2715	T2711	prep	of,activation
R2095	T2716	T2715	pobj	NF-κB,of
R2096	T2717	T2716	punct	(,NF-κB
R2097	T2718	T2716	appos	RANK,NF-κB
R2098	T2719	T2716	punct	),NF-κB
R2099	T2720	T2716	punct	",",NF-κB
R2100	T2721	T2725	det	a,member
R2101	T2722	T2725	compound	TNF,member
R2102	T2723	T2725	compound	receptor,member
R2103	T2724	T2725	compound	family,member
R2104	T2725	T2716	appos	member,NF-κB
R2105	T2726	T2727	punct	",",is
R2106	T2727	T2727	ROOT	is,is
R2107	T2728	T2727	acomp	important,is
R2108	T2729	T2728	prep	for,important
R2109	T2730	T2729	pobj	osteoclastogenesis,for
R2110	T2731	T2729	punct	",",for
R2111	T2732	T2728	cc	and,important
R2112	T2733	T2728	conj	defects,important
R2113	T2734	T2727	prep	in,is
R2114	T2735	T2736	amod	proper,RANK-NF-κB
R2115	T2736	T2734	pobj	RANK-NF-κB,in
R2116	T2737	T2738	nsubj	signalling,are
R2117	T2738	T2727	conj	are,is
R2118	T2739	T2738	acomp	likely,are
R2119	T2740	T2742	aux	to,involved
R2120	T2741	T2742	auxpass	be,involved
R2121	T2742	T2739	xcomp	involved,likely
R2122	T2743	T2742	prep	in,involved
R2123	T2744	T2745	compound	RA,pathology
R2124	T2745	T2743	pobj	pathology,in
R2125	T2746	T2745	cc	and,pathology
R2126	T2747	T2748	amod	other,diseases
R2127	T2748	T2745	conj	diseases,pathology
R2128	T2749	T2748	acl	associated,diseases
R2129	T2750	T2749	prep	with,associated
R2130	T2751	T2752	compound	bone,loss
R2131	T2752	T2753	compound	loss,[
R2132	T2753	T2755	compound	[,]
R2133	T2754	T2755	nummod	7,]
R2134	T2755	T2750	pobj	],with
R2135	T2756	T2738	punct	.,are
R2136	T2757	T2758	nsubj	CD40,is
R2137	T2758	T2758	ROOT	is,is
R2138	T2759	T2763	det	another,member
R2139	T2760	T2763	compound	TNF,member
R2140	T2761	T2763	compound	receptor,member
R2141	T2762	T2763	compound	family,member
R2142	T2763	T2758	attr	member,is
R2143	T2764	T2767	nsubjpass	that,expressed
R2144	T2765	T2767	auxpass	is,expressed
R2145	T2766	T2767	advmod	functionally,expressed
R2146	T2767	T2763	relcl	expressed,member
R2147	T2768	T2767	prep	on,expressed
R2148	T2769	T2770	det	a,variety
R2149	T2770	T2768	pobj	variety,on
R2150	T2771	T2770	prep	of,variety
R2151	T2772	T2773	compound	cell,types
R2152	T2773	T2771	pobj	types,of
R2153	T2774	T2770	punct	",",variety
R2154	T2775	T2770	prep	including,variety
R2155	T2776	T2777	amod	smooth,muscle
R2156	T2777	T2778	compound	muscle,fibroblasts
R2157	T2778	T2775	pobj	fibroblasts,including
R2158	T2779	T2778	prep	from,fibroblasts
R2159	T2780	T2783	amod	normal,patients
R2160	T2781	T2780	cc	and,normal
R2161	T2782	T2783	compound	RA,patients
R2162	T2783	T2779	pobj	patients,from
R2163	T2784	T2778	cc	and,fibroblasts
R2164	T2785	T2787	nmod	RA,cells
R2165	T2786	T2787	amod	synovial,cells
R2166	T2787	T2778	conj	cells,fibroblasts
R2167	T2788	T2787	punct	",",cells
R2168	T2789	T2790	compound	B,cells
R2169	T2790	T2787	conj	cells,cells
R2170	T2791	T2790	punct	",",cells
R2171	T2792	T2790	conj	macrophages,cells
R2172	T2793	T2792	punct	",",macrophages
R2173	T2794	T2792	cc	and,macrophages
R2174	T2795	T2796	amod	dendritic,cells
R2175	T2796	T2792	conj	cells,macrophages
R2176	T2797	T2758	punct	",",is
R2177	T2798	T2758	cc	and,is
R2178	T2799	T2801	aux	can,upregulated
R2179	T2800	T2801	auxpass	be,upregulated
R2180	T2801	T2758	conj	upregulated,is
R2181	T2802	T2801	agent	by,upregulated
R2182	T2803	T2804	amod	proinflammatory,cytokines
R2183	T2804	T2802	pobj	cytokines,by
R2184	T2805	T2804	prep	including,cytokines
R2185	T2806	T2807	compound	TNF,[
R2186	T2807	T2805	pobj	[,including
R2187	T2808	T2809	nummod	10,]
R2188	T2809	T2807	appos	],[
R2189	T2810	T2758	punct	.,is
R2190	T2811	T2834	advcl	Binding,triggers
R2191	T2812	T2811	prep	of,Binding
R2192	T2813	T2815	det	the,ligand
R2193	T2814	T2815	compound	CD40,ligand
R2194	T2815	T2812	pobj	ligand,of
R2195	T2816	T2817	punct	(,CD154
R2196	T2817	T2815	appos	CD154,ligand
R2197	T2818	T2817	punct	),CD154
R2198	T2819	T2815	punct	",",ligand
R2199	T2820	T2823	nsubjpass	which,expressed
R2200	T2821	T2823	auxpass	is,expressed
R2201	T2822	T2823	advmod	transiently,expressed
R2202	T2823	T2815	relcl	expressed,ligand
R2203	T2824	T2823	prep	on,expressed
R2204	T2825	T2826	det	the,surface
R2205	T2826	T2824	pobj	surface,on
R2206	T2827	T2826	prep	of,surface
R2207	T2828	T2832	amod	activated,cells
R2208	T2829	T2832	compound	CD4,cells
R2209	T2830	T2832	nummod	+,cells
R2210	T2831	T2832	compound	T,cells
R2211	T2832	T2827	pobj	cells,of
R2212	T2833	T2834	punct	",",triggers
R2213	T2834	T2834	ROOT	triggers,triggers
R2214	T2835	T2836	compound	NF-κB,activation
R2215	T2836	T2834	dobj	activation,triggers
R2216	T2837	T2836	acl	resulting,activation
R2217	T2838	T2837	prep	in,resulting
R2218	T2839	T2840	compound	fibroblast,proliferation
R2219	T2840	T2838	pobj	proliferation,in
R2220	T2841	T2840	cc	and,proliferation
R2221	T2842	T2840	conj	secretion,proliferation
R2222	T2843	T2842	prep	of,secretion
R2223	T2844	T2845	amod	proinflammatory,cytokines
R2224	T2845	T2843	pobj	cytokines,of
R2225	T2846	T2845	cc	and,cytokines
R2226	T2847	T2845	conj	chemokines,cytokines
R2227	T2848	T2845	punct	",",cytokines
R2228	T2849	T2850	nsubj	which,contributes
R2229	T2850	T2840	relcl	contributes,proliferation
R2230	T2851	T2850	prep	to,contributes
R2231	T2852	T2853	amod	joint,destruction
R2232	T2853	T2851	pobj	destruction,to
R2233	T2854	T2834	punct	.,triggers
R2234	T2855	T2864	advmod	However,led
R2235	T2856	T2864	punct	",",led
R2236	T2857	T2864	nsubj	studies,led
R2237	T2858	T2857	prep	with,studies
R2238	T2859	T2863	amod	antagonistic,antibodies
R2239	T2860	T2863	amod	anti-CD40,antibodies
R2240	T2861	T2860	cc	or,anti-CD40
R2241	T2862	T2860	conj	anti-CD154,anti-CD40
R2242	T2863	T2858	pobj	antibodies,with
R2243	T2923	T2918	pobj	lymphocytes,of
R2244	T2864	T2864	ROOT	led,led
R2245	T2924	T2925	punct	",",is
R2246	T2865	T2864	prep	to,led
R2247	T2925	T2925	ROOT	is,is
R2248	T2926	T2925	advmod	also,is
R2249	T2866	T2867	det	the,conclusion
R2250	T2927	T2925	acomp	characteristic,is
R2251	T2928	T2927	prep	for,characteristic
R2252	T2929	T2928	pobj	RA,for
R2253	T2867	T2865	pobj	conclusion,to
R2254	T2930	T2925	punct	",",is
R2255	T2931	T2925	cc	and,is
R2256	T2932	T2937	nsubjpass	antagonists,developed
R2257	T2868	T2872	mark	that,be
R2258	T2933	T2932	prep	of,antagonists
R2259	T2934	T2933	pobj	BAFF,of
R2260	T2935	T2937	aux	have,developed
R2261	T2869	T2870	compound	CD40,signals
R2262	T2936	T2937	auxpass	been,developed
R2263	T2937	T2925	conj	developed,is
R2264	T2938	T2939	aux	to,counter
R2265	T2870	T2872	nsubj	signals,be
R2266	T2939	T2937	advcl	counter,developed
R2267	T2940	T2941	compound	RA,[
R2268	T2941	T2939	dobj	[,counter
R2269	T2871	T2872	aux	may,be
R2270	T2942	T2943	nummod	13,]
R2271	T2943	T2941	appos	],[
R2272	T2944	T2925	punct	.,is
R2273	T2872	T2867	acl	be,conclusion
R2274	T2945	T2953	advmod	Finally,implicated
R2275	T2946	T2953	punct	",",implicated
R2276	T2947	T2950	amod	lymphotoxin,signalling
R2277	T2948	T2949	compound	β,receptor
R2278	T2949	T2950	compound	receptor,signalling
R2279	T2873	T2872	acomp	important,be
R2280	T2950	T2953	nsubjpass	signalling,implicated
R2281	T2951	T2953	aux	has,implicated
R2282	T2874	T2872	prep	at,be
R2283	T2952	T2953	auxpass	been,implicated
R2284	T2953	T2953	ROOT	implicated,implicated
R2285	T2954	T2953	prep	in,implicated
R2286	T2955	T2958	amod	tertiary,formation
R2287	T2875	T2877	det	the,stages
R2288	T2876	T2877	amod	initial,stages
R2289	T2956	T2958	amod	lymphoid,formation
R2290	T2877	T2874	pobj	stages,at
R2291	T2957	T2958	compound	organ,formation
R2292	T2958	T2954	pobj	formation,in
R2293	T2959	T2958	prep	at,formation
R2294	T2878	T2877	prep	of,stages
R2295	T2960	T2959	pobj	sites,at
R2296	T2961	T2960	prep	of,sites
R2297	T2962	T2963	amod	chronic,inflammation
R2298	T2879	T2880	compound	arthritis,induction
R2299	T2963	T2961	pobj	inflammation,of
R2300	T2964	T2960	prep	including,sites
R2301	T2965	T2966	compound	RA,[
R2302	T2880	T2878	pobj	induction,of
R2303	T2966	T2964	pobj	[,including
R2304	T2967	T2968	nummod	13,]
R2305	T2968	T2966	appos	],[
R2306	T2881	T2864	punct	",",led
R2307	T2969	T2953	punct	.,implicated
R2308	T2970	T2971	amod	Toll-like,receptors
R2309	T2882	T2864	cc	but,led
R2310	T2971	T2977	nsubjpass	receptors,implicated
R2311	T2972	T2971	punct	(,receptors
R2312	T2973	T2971	appos	TLRs,receptors
R2313	T2974	T2971	punct	),receptors
R2314	T2883	T2885	auxpass	are,required
R2315	T2975	T2977	aux	have,implicated
R2316	T2976	T2977	auxpass	been,implicated
R2317	T2977	T2977	ROOT	implicated,implicated
R2318	T2884	T2885	neg	not,required
R2319	T2978	T2977	prep	in,implicated
R2320	T2979	T2980	det	a,variety
R2321	T2885	T2864	conj	required,led
R2322	T2980	T2978	pobj	variety,in
R2323	T2981	T2980	prep	of,variety
R2324	T2982	T2983	amod	autoimmune,diseases
R2325	T2983	T2981	pobj	diseases,of
R2326	T2984	T2977	cc	and,implicated
R2327	T2985	T2977	conj	are,implicated
R2328	T2886	T2889	mark	once,established
R2329	T2986	T2987	amod	potential,candidates
R2330	T2987	T2985	attr	candidates,are
R2331	T2988	T2987	prep	for,candidates
R2332	T2989	T2988	pcomp	inducing,for
R2333	T2887	T2889	nsubjpass	disease,established
R2334	T2990	T2991	amod	NF-κB-dependent,inflammation
R2335	T2991	T2989	dobj	inflammation,inducing
R2336	T2888	T2889	auxpass	is,established
R2337	T2992	T2991	prep	in,inflammation
R2338	T2993	T2992	pobj	RA,in
R2339	T2994	T2977	punct	.,implicated
R2340	T2995	T3021	prep	In,reported
R2341	T2889	T2885	advcl	established,required
R2342	T2996	T2995	pobj	addition,In
R2343	T2997	T2996	prep	to,addition
R2344	T2998	T2999	amod	microbial,ligands
R2345	T2890	T2889	cc	and,established
R2346	T2999	T2997	pobj	ligands,to
R2347	T3000	T2999	punct	",",ligands
R2348	T2891	T2889	conj	pathogenic,established
R2349	T3001	T3003	det	an,number
R2350	T3002	T3003	amod	increasing,number
R2351	T3003	T2999	appos	number,ligands
R2352	T2892	T2893	nsubj	antibodies,are
R2353	T3004	T3003	prep	of,number
R2354	T3005	T3006	amod	endogenous,ligands
R2355	T3006	T3004	pobj	ligands,of
R2356	T2893	T2864	conj	are,led
R2357	T3007	T3006	punct	-,ligands
R2358	T3008	T3009	det	a,group
R2359	T3009	T3003	conj	group,number
R2360	T2894	T2893	advmod	already,are
R2361	T3010	T3009	prep	of,group
R2362	T3011	T3010	pobj	proteins,of
R2363	T3012	T3011	acl	derived,proteins
R2364	T2895	T2893	acomp	present,are
R2365	T3013	T3012	prep	from,derived
R2366	T3014	T3015	compound	host,tissues
R2367	T3015	T3013	pobj	tissues,from
R2368	T2896	T2898	compound	[,]
R2369	T3016	T3015	cc	and,tissues
R2370	T3017	T3015	conj	cells,tissues
R2371	T3018	T3021	punct	-,reported
R2372	T2897	T2898	compound	"11,12",]
R2373	T3019	T3021	aux	have,reported
R2374	T2898	T2893	attr	],are
R2375	T2899	T2893	punct	.,are
R2376	T3020	T3021	auxpass	been,reported
R2377	T3021	T3021	ROOT	reported,reported
R2378	T3022	T3021	prep	as,reported
R2379	T3023	T3024	compound	candidate,activators
R2380	T2900	T2901	amod	Enhanced,expression
R2381	T3024	T3022	pobj	activators,as
R2382	T3025	T3024	prep	of,activators
R2383	T3026	T3025	pobj	TLRs,of
R2384	T3027	T3024	acl	inducing,activators
R2385	T2901	T2925	nsubj	expression,is
R2386	T3028	T3030	amod	so-called,inflammation
R2387	T2902	T2901	prep	of,expression
R2388	T3029	T3030	amod	sterile,inflammation
R2389	T3030	T3027	dobj	inflammation,inducing
R2390	T3031	T3030	punct	(,inflammation
R2391	T2903	T2907	det	the,member
R2392	T3032	T3030	acl	reviewed,inflammation
R2393	T2904	T2907	compound	TNF,member
R2394	T3033	T3032	prep	in,reviewed
R2395	T2905	T2907	compound	receptor,member
R2396	T3034	T3033	pobj	[,in
R2397	T3035	T3036	nummod	"14,15",]
R2398	T2906	T2907	compound	family,member
R2399	T3036	T3034	appos	],[
R2400	T2907	T2910	nmod	member,factor
R2401	T3037	T3034	punct	),[
R2402	T2908	T2910	nmod	B-cell,factor
R2403	T3038	T3021	punct	.,reported
R2404	T3039	T3041	nsubjpass	TLRs,expressed
R2405	T3040	T3041	auxpass	are,expressed
R2406	T2909	T2910	amod	activating,factor
R2407	T3041	T3041	ROOT	expressed,expressed
R2408	T3042	T3041	prep	in,expressed
R2409	T3043	T3045	compound	RA,tissues
R2410	T2910	T2902	pobj	factor,of
R2411	T3044	T3045	compound	synovial,tissues
R2412	T3045	T3042	pobj	tissues,in
R2413	T2911	T2912	punct	(,BAFF
R2414	T3046	T3045	cc	and,tissues
R2415	T3047	T3049	amod	various,ligands
R2416	T3048	T3049	amod	endogenous,ligands
R2417	T2912	T2910	appos	BAFF,factor
R2418	T3049	T3045	conj	ligands,tissues
R2419	T3050	T3041	conj	are,expressed
R2420	T2913	T2910	punct	),factor
R2421	T3051	T3050	acomp	present,are
R2422	T3052	T3050	prep	within,are
R2423	T3053	T3055	det	the,joints
R2424	T3054	T3055	amod	inflamed,joints
R2425	T2914	T2901	punct	",",expression
R2426	T3055	T3052	pobj	joints,within
R2427	T3056	T3055	prep	of,joints
R2428	T3057	T3058	compound	RA,patients
R2429	T3058	T3056	pobj	patients,of
R2430	T3059	T3041	punct	.,expressed
R2431	T3060	T3075	advmod	Moreover,identify
R2432	T2915	T2901	acl	allowing,expression
R2433	T3061	T3075	punct	",",identify
R2434	T3062	T3063	compound	animal,models
R2435	T3063	T3075	nsubj	models,identify
R2436	T2916	T2917	det	the,survival
R2437	T3064	T3063	acl	using,models
R2438	T3065	T3067	compound	TLR,mice
R2439	T3066	T3067	compound	knockout,mice
R2440	T2917	T2915	dobj	survival,allowing
R2441	T3067	T3064	dobj	mice,using
R2442	T3068	T3067	cc	or,mice
R2443	T3069	T3067	conj	strategies,mice
R2444	T2918	T2917	prep	of,survival
R2445	T3070	T3071	aux	to,block
R2446	T3071	T3064	xcomp	block,using
R2447	T3072	T3071	dobj	TLR,block
R2448	T3073	T3064	conj	signalling,using
R2449	T2919	T2921	npadvmod	autoantibody,producing
R2450	T3074	T3075	advmod	clearly,identify
R2451	T3075	T3075	ROOT	identify,identify
R2452	T3076	T3077	amod	TLR-dependent,inflammation
R2453	T2920	T2921	punct	-,producing
R2454	T3077	T3075	dobj	inflammation,identify
R2455	T3078	T3075	prep	as,identify
R2456	T3079	T3078	pcomp	being,as
R2457	T2921	T2923	amod	producing,lymphocytes
R2458	T3080	T3079	acomp	important,being
R2459	T3081	T3079	prep	in,being
R2460	T3082	T3083	det	the,pathogenesis
R2461	T2922	T2923	compound	B,lymphocytes
R2462	T3083	T3081	pobj	pathogenesis,in
R2463	T3084	T3083	prep	of,pathogenesis
R2464	T3085	T3086	det	the,disease
R2465	T3117	T3093	punct	",",protein
R2466	T3086	T3084	pobj	disease,of
R2467	T3087	T3075	punct	.,identify
R2468	T3088	T3091	amod	High,box
R2469	T3118	T3118	ROOT	is,is
R2470	T3089	T3091	compound	mobility,box
R2471	T3090	T3091	compound	group,box
R2472	T3091	T3093	compound	box,protein
R2473	T3092	T3093	compound	chromosomal,protein
R2474	T3119	T3118	attr	one,is
R2475	T3093	T3118	nsubj	protein,is
R2476	T3094	T3093	nummod	1,protein
R2477	T3095	T3093	punct	(,protein
R2478	T3096	T3093	appos	HMGB1,protein
R2479	T3097	T3093	punct	),protein
R2480	T3098	T3093	punct	",",protein
R2481	T3120	T3119	prep	of,one
R2482	T3099	T3103	det	a,component
R2483	T3100	T3101	advmod	highly,conserved
R2484	T3101	T3103	amod	conserved,component
R2485	T3102	T3103	compound	chromatin,component
R2486	T3121	T3126	det	the,ligands
R2487	T3103	T3093	appos	component,protein
R2488	T3104	T3108	nsubjpass	that,secreted
R2489	T3122	T3123	advmod	most,putative
R2490	T3105	T3108	aux	can,secreted
R2491	T3106	T3108	auxpass	be,secreted
R2492	T3107	T3108	advmod	actively,secreted
R2493	T3123	T3126	amod	putative,ligands
R2494	T3108	T3103	relcl	secreted,component
R2495	T3109	T3108	agent	by,secreted
R2496	T3110	T3109	pobj	macrophages,by
R2497	T3124	T3126	amod	endogenous,ligands
R2498	T3111	T3110	cc	or,macrophages
R2499	T3112	T3113	advmod	passively,released
R2500	T3113	T3110	acl	released,macrophages
R2501	T3125	T3126	nummod	TLR4,ligands
R2502	T3114	T3113	agent	by,released
R2503	T3126	T3120	pobj	ligands,of
R2504	T3127	T3126	acl	involved,ligands
R2505	T3115	T3116	amod	necrotic,cells
R2506	T3116	T3114	pobj	cells,by
R2507	T3128	T3127	prep	in,involved
R2508	T3129	T3130	compound	RA,pathology
R2509	T3130	T3128	pobj	pathology,in
R2510	T3131	T3118	punct	.,is
R2511	T3132	T3134	nsubjpass	HMGB1,increased
R2512	T3214	T3210	relcl	involved,ligands
R2513	T3215	T3214	prep	in,involved
R2514	T3133	T3134	auxpass	is,increased
R2515	T3216	T3217	compound	RA,pathology
R2516	T3217	T3215	pobj	pathology,in
R2517	T3218	T3218	ROOT	are,are
R2518	T3134	T3134	ROOT	increased,increased
R2519	T3219	T3221	amod	extracellular,components
R2520	T3220	T3221	compound	matrix,components
R2521	T3135	T3134	prep	in,increased
R2522	T3221	T3218	attr	components,are
R2523	T3222	T3223	amod	such,as
R2524	T3223	T3221	prep	as,components
R2525	T3136	T3138	nmod	RA,tissue
R2526	T3224	T3223	pobj	fibrinogen,as
R2527	T3225	T3224	punct	",",fibrinogen
R2528	T3137	T3138	amod	synovial,tissue
R2529	T3226	T3224	conj	fibronectin,fibrinogen
R2530	T3227	T3226	punct	",",fibronectin
R2531	T3228	T3226	conj	biglycan,fibronectin
R2532	T3138	T3135	pobj	tissue,in
R2533	T3229	T3228	punct	",",biglycan
R2534	T3230	T3231	compound	tenascin,C
R2535	T3231	T3228	conj	C,biglycan
R2536	T3139	T3138	cc	and,tissue
R2537	T3232	T3231	punct	",",C
R2538	T3233	T3231	cc	and,C
R2539	T3234	T3236	amod	hyal-uronic,fragments
R2540	T3140	T3141	nsubj	HMGB1,neutralising
R2541	T3235	T3236	compound	acid,fragments
R2542	T3236	T3231	conj	fragments,C
R2543	T3237	T3236	punct	(,fragments
R2544	T3141	T3138	conj	neutralising,tissue
R2545	T3238	T3236	acl	reviewed,fragments
R2546	T3239	T3238	prep	in,reviewed
R2547	T3142	T3141	dobj	antibodies,neutralising
R2548	T3240	T3239	pobj	[,in
R2549	T3241	T3242	nummod	"14,15",]
R2550	T3143	T3142	cc	or,antibodies
R2551	T3242	T3240	appos	],[
R2552	T3243	T3240	punct	),[
R2553	T3244	T3218	punct	.,are
R2554	T3144	T3147	det	the,domain
R2555	T3245	T3249	advmod	Together,suggest
R2556	T3246	T3249	punct	",",suggest
R2557	T3247	T3248	det	these,studies
R2558	T3145	T3147	amod	antagonistic,domain
R2559	T3248	T3249	nsubj	studies,suggest
R2560	T3249	T3249	ROOT	suggest,suggest
R2561	T3250	T3260	mark	that,contribute
R2562	T3146	T3147	compound	BoxA,domain
R2563	T3251	T3253	amod	several,ligands
R2564	T3252	T3253	compound	TLR,ligands
R2565	T3253	T3260	nsubj	ligands,contribute
R2566	T3147	T3142	conj	domain,antibodies
R2567	T3254	T3253	prep	in,ligands
R2568	T3255	T3258	det	the,tissue
R2569	T3256	T3258	amod	inflamed,tissue
R2570	T3148	T3147	prep	of,domain
R2571	T3257	T3258	amod	joint,tissue
R2572	T3258	T3254	pobj	tissue,in
R2573	T3259	T3260	aux	may,contribute
R2574	T3149	T3148	pobj	HMGB1,of
R2575	T3260	T3249	ccomp	contribute,suggest
R2576	T3261	T3260	prep	to,contribute
R2577	T3262	T3263	amod	NF-κB,activation
R2578	T3263	T3261	pobj	activation,to
R2579	T3264	T3263	cc	and,activation
R2580	T3265	T3267	amod	inflammatory,expression
R2581	T3150	T3134	conj	protect,increased
R2582	T3266	T3267	compound	gene,expression
R2583	T3267	T3263	conj	expression,activation
R2584	T3268	T3263	prep	in,activation
R2585	T3151	T3150	prep	against,protect
R2586	T3269	T3268	pobj	RA,in
R2587	T3270	T3249	punct	.,suggest
R2588	T3152	T3153	amod	collagen-induced,arthritis
R2589	T3153	T3151	pobj	arthritis,against
R2590	T3154	T3153	prep	in,arthritis
R2591	T3155	T3154	pobj	mice,in
R2592	T3156	T3158	nmod	[,]
R2593	T3157	T3158	nummod	16,]
R2594	T3158	T3158	ROOT	],]
R2595	T3159	T3134	punct	.,increased
R2596	T3160	T3161	amod	Myeloid-related,protein
R2597	T3161	T3181	nsubj	protein,are
R2598	T3162	T3161	nummod	8,protein
R2599	T3163	T3161	cc	and,protein
R2600	T3164	T3165	amod	myeloid-related,protein
R2601	T3165	T3161	conj	protein,protein
R2602	T3166	T3165	nummod	14,protein
R2603	T3167	T3165	punct	",",protein
R2604	T3168	T3171	amod	damage-associated,molecules
R2605	T3169	T3170	amod	molecular,pattern
R2606	T3170	T3171	compound	pattern,molecules
R2607	T3171	T3165	conj	molecules,protein
R2608	T3172	T3171	acl	belonging,molecules
R2609	T3173	T3172	prep	to,belonging
R2610	T3174	T3176	det	the,family
R2611	T3175	T3176	compound	S100,family
R2615	T3176	T3173	pobj	family,to
R2620	T3177	T3176	prep	of,family
R2622	T3178	T3179	amod	calcium-binding,proteins
R2624	T3179	T3177	pobj	proteins,of
R2625	T3180	T3181	punct	",",are
R2626	T3181	T3181	ROOT	are,are
R2631	T3182	T3181	advmod	also,are
R2632	T3183	T3184	advmod	abundantly,present
R2634	T3184	T3181	acomp	present,are
R2635	T3185	T3184	prep	in,present
R2636	T3186	T3188	nmod	RA,fluid
R2639	T3187	T3188	compound	synovial,fluid
R2640	T3188	T3185	pobj	fluid,in
R2641	T3189	T3181	punct	",",are
R2642	T3190	T3181	cc	and,are
R2643	T3191	T3193	aux	have,suggested
R2644	T3192	T3193	auxpass	been,suggested
R2645	T3193	T3181	conj	suggested,are
R2646	T3194	T3196	aux	to,involved
R2647	T3195	T3196	auxpass	be,involved
R2649	T3196	T3193	xcomp	involved,suggested
R2650	T3197	T3196	prep	in,involved
R2651	T3198	T3200	amod	TLR4-induced,inflammation
R2653	T3199	T3200	amod	chronic,inflammation
R2655	T3200	T3197	pobj	inflammation,in
R2657	T3201	T3200	prep	in,inflammation
R2659	T3202	T3203	compound	RA,[
R2660	T3203	T3201	pobj	[,in
R2661	T3204	T3205	nummod	"17,18",]
R2665	T3205	T3193	conj	],suggested
R2668	T3206	T3181	punct	.,are
R2669	T3207	T3210	amod	Other,ligands
R2674	T3208	T3210	amod	endogenous,ligands
R2677	T3209	T3210	compound	TLR,ligands
R2678	T3210	T3218	nsubj	ligands,are
R2679	T3211	T3214	nsubjpass	that,involved
R2680	T3212	T3214	aux	may,involved
R2681	T3213	T3214	auxpass	be,involved

DLUT931

Id	Subject	Object	Predicate	Lexical cue
T3400	3519-3526	Positive_regulation	denotes	induced
T3399	3096-3105	Positive_regulation	denotes	increased
T3398	2981-2989	Localization	denotes	released
T3397	2944-2952	Localization	denotes	secreted
T3396	1705-1713	Positive_regulation	denotes	Enhanced
T3395	1714-1724	Gene_expression	denotes	expression
T3394	1213-1222	Gene_expression	denotes	expressed
T3393	1156-1163	Binding	denotes	Binding
T3392	1095-1106	Positive_regulation	denotes	upregulated
T3391	916-925	Gene_expression	denotes	expressed
T3390	599-609	Positive_regulation	denotes	activation
T3389	3708-3718	Protein	denotes	tenascin C
T3388	3698-3706	Protein	denotes	biglycan
T3387	3685-3696	Protein	denotes	fibronectin
T3386	3514-3518	Protein	denotes	TLR4
T3385	3290-3316	Protein	denotes	myeloid-related protein 14
T3384	3260-3285	Protein	denotes	Myeloid-related protein 8
T3383	3197-3202	Protein	denotes	HMGB1
T3382	3132-3137	Protein	denotes	HMGB1
T3381	3087-3092	Protein	denotes	HMGB1
T3380	3048-3060	Protein	denotes	TLR4 ligands
T3379	2903-2922	Protein	denotes	chromatin component
T3378	2876-2881	Protein	denotes	HMGB1
T3377	2829-2874	Protein	denotes	High mobility group box chromosomal protein 1
T3376	1960-1982	Protein	denotes	lymphotoxin β receptor
T3375	1906-1910	Protein	denotes	BAFF
T3374	1785-1789	Protein	denotes	BAFF
T3373	1759-1783	Protein	denotes	B-cell activating factor
T3372	1525-1529	Protein	denotes	CD40
T3371	1251-1254	Protein	denotes	CD4
T3370	1184-1189	Protein	denotes	CD154
T3369	1171-1182	Protein	denotes	CD40 ligand
T3368	1146-1149	Protein	denotes	TNF
T3367	868-894	Protein	denotes	TNF receptor family member
T3366	852-856	Protein	denotes	CD40
T3365	738-742	Protein	denotes	RANK
T3364	642-646	Protein	denotes	RANK
T3363	613-640	Protein	denotes	receptor activator of NF-κB
T3362	399-402	Protein	denotes	TNF
T3361	324-327	Protein	denotes	TNF
T3360	265-268	Protein	denotes	TNF
R2685	T3367	T3392	themeOf	TNF receptor family member,upregulated
R2686	T3367	T3391	themeOf	TNF receptor family member,expressed
R2687	T3369	T3393	themeOf	CD40 ligand,Binding
R2688	T3370	T3393	themeOf	CD154,Binding
R2689	T3370	T3394	themeOf	CD154,expressed
R2691	T3373	T3395	themeOf	B-cell activating factor,expression
R2692	T3374	T3395	themeOf	BAFF,expression
R2695	T3379	T3397	themeOf	chromatin component,secreted
R2696	T3379	T3398	themeOf	chromatin component,released
R2697	T3381	T3399	themeOf	HMGB1,increased
R2700	T3386	T3400	themeOf	TLR4,induced
R2705	T3395	T3396	themeOf	expression,Enhanced
R2706	T3395	T3396	themeOf	expression,Enhanced
R2683	T3363	T3390	themeOf	receptor activator of NF-κB,activation
R2684	T3366	T3391	themeOf	CD40,expressed

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T3287	3514-3518	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T3286	3048-3052	http://www.uniprot.org/uniprot/O00206	denotes	TLR4
T3285	1251-1254	http://www.uniprot.org/uniprot/P01730	denotes	CD4
T3284	1481-1486	http://www.uniprot.org/uniprot/P29965	denotes	CD154
T3283	1184-1189	http://www.uniprot.org/uniprot/P29965	denotes	CD154
T3282	1171-1182	http://www.uniprot.org/uniprot/P29965	denotes	CD40 ligand
T3281	1525-1529	http://www.uniprot.org/uniprot/P25942	denotes	CD40
T3280	1468-1472	http://www.uniprot.org/uniprot/P25942	denotes	CD40
T3279	1171-1175	http://www.uniprot.org/uniprot/P25942	denotes	CD40
T3278	852-856	http://www.uniprot.org/uniprot/P25942	denotes	CD40
T3277	1732-1735	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T3276	1146-1149	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T3275	868-871	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T3274	651-654	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T3273	399-402	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T3272	324-327	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T3271	265-268	http://www.uniprot.org/uniprot/P01375	denotes	TNF

bionlp-st-ge-2016-test-proteins

Id	Subject	Object	Predicate	Lexical cue
T1846	3708-3718	Protein	denotes	tenascin C
T1845	3698-3706	Protein	denotes	biglycan
T1844	3685-3696	Protein	denotes	fibronectin
T1843	3514-3518	Protein	denotes	TLR4
T1842	3290-3316	Protein	denotes	myeloid-related protein 14
T1841	3260-3285	Protein	denotes	Myeloid-related protein 8
T1840	3197-3202	Protein	denotes	HMGB1
T1839	3132-3137	Protein	denotes	HMGB1
T1838	3087-3092	Protein	denotes	HMGB1
T1837	3048-3060	Protein	denotes	TLR4 ligands
T1836	2903-2922	Protein	denotes	chromatin component
T1835	2876-2881	Protein	denotes	HMGB1
T1834	2829-2874	Protein	denotes	High mobility group box chromosomal protein 1
T1833	1960-1982	Protein	denotes	lymphotoxin β receptor
T1832	1906-1910	Protein	denotes	BAFF
T1831	1785-1789	Protein	denotes	BAFF
T1830	1759-1783	Protein	denotes	B-cell activating factor
T1829	1525-1529	Protein	denotes	CD40
T1828	1251-1254	Protein	denotes	CD4
T1827	1184-1189	Protein	denotes	CD154
T1826	1171-1182	Protein	denotes	CD40 ligand
T1825	1146-1149	Protein	denotes	TNF
T1824	868-894	Protein	denotes	TNF receptor family member
T1823	852-856	Protein	denotes	CD40
T1822	738-742	Protein	denotes	RANK
T1821	642-646	Protein	denotes	RANK
T1820	613-640	Protein	denotes	receptor activator of NF-κB
T1819	399-402	Protein	denotes	TNF
T1818	324-327	Protein	denotes	TNF
T1817	265-268	Protein	denotes	TNF

bionlp-st-ge-2016-coref

Id	Subject	Object	Predicate	Lexical cue
T1811	895-899	Anaphor	denotes	that
T1816	2903-2922	Antecedent	denotes	chromatin component
T1815	2923-2927	Anaphor	denotes	that
T1814	1171-1182	Antecedent	denotes	CD40 ligand
T1813	1192-1197	Anaphor	denotes	which
T1812	852-856	Antecedent	denotes	CD40
R1311	T1811	T1812	boundBy	that,CD40
R1312	T1813	T1814	boundBy	which,CD40 ligand
R1313	T1815	T1816	boundBy	that,chromatin component

2_test

Id	Subject	Object	Predicate	Lexical cue
21639951-19798034-4289433	394-395	19798034	denotes	9
21639951-18982160-4289434	588-589	18982160	denotes	3
21639951-16356770-4289435	848-849	16356770	denotes	7
21639951-8973616-4289436	1151-1153	8973616	denotes	10
21639951-7689748-4289437	1697-1699	7689748	denotes	11
21639951-11083282-4289438	1700-1702	11083282	denotes	12
21639951-18771589-4289439	1946-1948	18771589	denotes	13
21639951-18771589-4289440	2098-2100	18771589	denotes	13
21639951-19772831-4289441	2507-2509	19772831	denotes	14
21639951-20629986-4289442	2510-2512	20629986	denotes	15
21639951-12847700-4289443	3255-3257	12847700	denotes	16
21639951-10728757-4289444	3555-3557	10728757	denotes	17
21639951-17767165-4289445	3558-3560	17767165	denotes	18
21639951-19772831-4289446	3765-3767	19772831	denotes	14
21639951-20629986-4289447	3768-3770	20629986	denotes	15

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T2489	3931-3933	NN	denotes	RA
T2488	3928-3930	IN	denotes	in
T2487	3917-3927	NN	denotes	expression
T2486	3912-3916	NN	denotes	gene
T2485	3899-3911	JJ	denotes	inflammatory
T2484	3895-3898	CC	denotes	and
T2483	3884-3894	NN	denotes	activation
T2482	3878-3883	NN	denotes	NF-κB
T2481	3875-3877	TO	denotes	to
T2480	3864-3874	VB	denotes	contribute
T2479	3860-3863	MD	denotes	may
T2478	3853-3859	NN	denotes	tissue
T2477	3847-3852	JJ	denotes	joint
T2476	3838-3846	JJ	denotes	inflamed
T2475	3834-3837	DT	denotes	the
T2474	3831-3833	IN	denotes	in
T2473	3823-3830	NN	denotes	ligands
T2472	3819-3822	NN	denotes	TLR
T2471	3811-3818	JJ	denotes	several
T2470	3806-3810	IN	denotes	that
T2469	3798-3805	VB	denotes	suggest
T2468	3790-3797	NN	denotes	studies
T2467	3784-3789	DT	denotes	these
T2466	3782-3783	-COMMA-	denotes	,
T2465	3774-3782	RB	denotes	Together
T2464	3771-3772	-RRB-	denotes	)
T2463	3770-3771	-RRB-	denotes	]
T2462	3765-3770	CD	denotes	14,15
T2461	3764-3765	-LRB-	denotes	[
T2460	3761-3763	IN	denotes	in
T2459	3752-3760	VB	denotes	reviewed
T2458	3751-3752	-LRB-	denotes	(
T2457	3741-3750	NN	denotes	fragments
T2456	3736-3740	NN	denotes	acid
T2455	3724-3735	JJ	denotes	hyal-uronic
T2454	3720-3723	CC	denotes	and
T2453	3718-3719	-COMMA-	denotes	,
T2452	3717-3718	NN	denotes	C
T2451	3708-3716	NN	denotes	tenascin
T2450	3706-3707	-COMMA-	denotes	,
T2449	3698-3706	NN	denotes	biglycan
T2448	3696-3697	-COMMA-	denotes	,
T2447	3685-3696	NN	denotes	fibronectin
T2446	3683-3684	-COMMA-	denotes	,
T2445	3673-3683	NN	denotes	fibrinogen
T2444	3670-3672	IN	denotes	as
T2443	3665-3669	JJ	denotes	such
T2442	3654-3664	NN	denotes	components
T2441	3647-3653	NN	denotes	matrix
T2440	3633-3646	JJ	denotes	extracellular
T2439	3629-3632	VB	denotes	are
T2438	3619-3628	NN	denotes	pathology
T2437	3616-3618	NN	denotes	RA
T2436	3613-3615	IN	denotes	in
T2435	3604-3612	VB	denotes	involved
T2434	3601-3603	VB	denotes	be
T2433	3597-3600	MD	denotes	may
T2432	3592-3596	WDT	denotes	that
T2431	3584-3591	NN	denotes	ligands
T2430	3580-3583	NN	denotes	TLR
T2429	3569-3579	JJ	denotes	endogenous
T2428	3563-3568	JJ	denotes	Other
T2427	3560-3561	-RRB-	denotes	]
T2426	3555-3560	CD	denotes	17,18
T2425	3554-3555	-LRB-	denotes	[
T2424	3551-3553	NN	denotes	RA
T2423	3548-3550	IN	denotes	in
T2422	3535-3547	NN	denotes	inflammation
T2421	3527-3534	JJ	denotes	chronic
T2420	3514-3526	JJ	denotes	TLR4-induced
T2419	3511-3513	IN	denotes	in
T2418	3502-3510	VB	denotes	involved
T2047	1167-1170	DT	denotes	the
T2046	1164-1166	IN	denotes	of
T2045	1156-1163	NN	denotes	Binding
T2044	1153-1154	-RRB-	denotes	]
T2043	1151-1153	CD	denotes	10
T2042	1150-1151	-LRB-	denotes	[
T2041	1146-1149	NN	denotes	TNF
T2040	1136-1145	VB	denotes	including
T2039	1126-1135	NN	denotes	cytokines
T2038	1110-1125	JJ	denotes	proinflammatory
T2037	1107-1109	IN	denotes	by
T2036	1095-1106	VB	denotes	upregulated
T2035	1092-1094	VB	denotes	be
T2034	1088-1091	MD	denotes	can
T2033	1084-1087	CC	denotes	and
T2032	1082-1083	-COMMA-	denotes	,
T2031	1077-1082	NN	denotes	cells
T2030	1067-1076	JJ	denotes	dendritic
T2029	1063-1066	CC	denotes	and
T2028	1061-1062	-COMMA-	denotes	,
T2027	1050-1061	NN	denotes	macrophages
T2026	1048-1049	-COMMA-	denotes	,
T2025	1043-1048	NN	denotes	cells
T2024	1041-1042	NN	denotes	B
T2023	1039-1040	-COMMA-	denotes	,
T2022	1034-1039	NN	denotes	cells
T2021	1025-1033	JJ	denotes	synovial
T2020	1022-1024	NN	denotes	RA
T2019	1018-1021	CC	denotes	and
T2018	1009-1017	NN	denotes	patients
T2017	1006-1008	NN	denotes	RA
T2016	1002-1005	CC	denotes	and
T2015	995-1001	JJ	denotes	normal
T2014	990-994	IN	denotes	from
T2013	978-989	NN	denotes	fibroblasts
T2012	971-977	NN	denotes	muscle
T2011	964-970	JJ	denotes	smooth
T2010	954-963	VB	denotes	including
T2009	952-953	-COMMA-	denotes	,
T2008	947-952	NN	denotes	types
T2007	942-946	NN	denotes	cell
T2006	939-941	IN	denotes	of
T2005	931-938	NN	denotes	variety
T2004	929-930	DT	denotes	a
T2003	926-928	IN	denotes	on
T2002	916-925	VB	denotes	expressed
T2001	903-915	RB	denotes	functionally
T2000	900-902	VB	denotes	is
T1999	895-899	WDT	denotes	that
T1998	888-894	NN	denotes	member
T1997	881-887	NN	denotes	family
T1996	872-880	NN	denotes	receptor
T1995	868-871	NN	denotes	TNF
T1994	860-867	DT	denotes	another
T1993	857-859	VB	denotes	is
T1992	852-856	NN	denotes	CD40
T1991	849-850	-RRB-	denotes	]
T1990	848-849	CD	denotes	7
T1989	847-848	-LRB-	denotes	[
T1988	842-846	NN	denotes	loss
T1987	837-841	NN	denotes	bone
T1986	832-836	IN	denotes	with
T1985	821-831	VB	denotes	associated
T1984	812-820	NN	denotes	diseases
T1983	806-811	JJ	denotes	other
T1982	802-805	CC	denotes	and
T1981	792-801	NN	denotes	pathology
T1980	789-791	NN	denotes	RA
T1979	786-788	IN	denotes	in
T1978	777-785	VB	denotes	involved
T1977	774-776	VB	denotes	be
T1976	771-773	TO	denotes	to
T1975	764-770	JJ	denotes	likely
T1974	760-763	VB	denotes	are
T1973	749-759	NN	denotes	signalling
T1972	738-748	NN	denotes	RANK-NF-κB
T1971	731-737	JJ	denotes	proper
T1970	728-730	IN	denotes	in
T1969	720-727	NN	denotes	defects
T1968	716-719	CC	denotes	and
T1967	714-715	-COMMA-	denotes	,
T1966	696-714	NN	denotes	osteoclastogenesis
T1965	692-695	IN	denotes	for
T1964	682-691	JJ	denotes	important
T1963	679-681	VB	denotes	is
T1962	677-678	-COMMA-	denotes	,
T1961	671-677	NN	denotes	member
T1960	664-670	NN	denotes	family
T1959	655-663	NN	denotes	receptor
T1958	651-654	NN	denotes	TNF
T1957	649-650	DT	denotes	a
T1956	647-648	-COMMA-	denotes	,
T1955	646-647	-RRB-	denotes	)
T1954	642-646	NN	denotes	RANK
T1953	641-642	-LRB-	denotes	(
T1952	635-640	NN	denotes	NF-κB
T1951	632-634	IN	denotes	of
T1950	622-631	NN	denotes	activator
T1949	613-621	NN	denotes	receptor
T1948	610-612	IN	denotes	by
T1947	599-609	NN	denotes	activation
T1946	593-598	NN	denotes	NF-κB
T1945	590-591	-RRB-	denotes	)
T1944	589-590	-RRB-	denotes	]
T1943	588-589	CD	denotes	3
T1942	587-588	-LRB-	denotes	[
T1941	584-586	IN	denotes	in
T1940	575-583	VB	denotes	reviewed
T1939	574-575	-LRB-	denotes	(
T1938	571-573	NN	denotes	RA
T1937	568-570	IN	denotes	in
T1936	557-567	NN	denotes	activities
T1935	540-556	JJ	denotes	pro-inflammatory
T1934	534-539	PRP-DOLLAR-	denotes	their
T1933	531-533	IN	denotes	of
T1932	526-530	JJ	denotes	most
T1931	517-525	VB	denotes	mediates
T1930	507-516	NN	denotes	cytokines
T1929	501-506	DT	denotes	these
T1928	498-500	IN	denotes	by
T1927	487-497	NN	denotes	activation
T1926	481-486	NN	denotes	NF-κB
T1925	476-480	IN	denotes	that
T1924	467-475	VB	denotes	expected
T1923	464-466	VB	denotes	be
T1922	460-463	MD	denotes	can
T1921	457-459	PRP	denotes	it
T1920	453-456	CC	denotes	and
T1919	447-452	NN	denotes	NF-κB
T1918	444-446	IN	denotes	of
T1917	433-443	NN	denotes	activators
T1916	426-432	JJ	denotes	potent
T1915	421-425	RB	denotes	very
T1914	416-420	DT	denotes	both
T1913	412-415	VB	denotes	are
T1912	407-411	NN	denotes	IL-1
T1911	403-406	CC	denotes	and
T1910	399-402	NN	denotes	TNF
T1909	396-397	-RRB-	denotes	)
T1908	395-396	-RRB-	denotes	]
T1907	394-395	CD	denotes	9
T1906	393-394	-LRB-	denotes	[
T1905	390-392	IN	denotes	in
T1904	381-389	VB	denotes	reviewed
T1903	380-381	-LRB-	denotes	(
T1902	377-379	NN	denotes	RA
T1901	370-376	JJ	denotes	severe
T1900	366-369	IN	denotes	for
T1899	356-365	NN	denotes	treatment
T1898	346-355	JJ	denotes	effective
T1897	343-345	DT	denotes	an
T1896	340-342	VB	denotes	is
T1895	328-339	NN	denotes	antagonists
T1894	324-327	NN	denotes	TNF
T1893	321-323	IN	denotes	of
T1892	306-320	NN	denotes	administration
T1891	302-305	CC	denotes	and
T1890	300-301	-COMMA-	denotes	,
T1889	296-300	NN	denotes	role
T1888	286-295	JJ	denotes	important
T1887	283-285	DT	denotes	an
T1886	278-282	VB	denotes	play
T1885	273-277	NN	denotes	IL-1
T1884	269-272	CC	denotes	and
T1883	265-268	NN	denotes	TNF
T1882	262-264	IN	denotes	as
T1881	257-261	JJ	denotes	such
T1880	247-256	NN	denotes	cytokines
T1879	231-246	JJ	denotes	proinflammatory
T1878	226-230	IN	denotes	that
T1877	217-225	VB	denotes	accepted
T1876	212-216	RB	denotes	well
T1875	209-211	VB	denotes	is
T1874	206-208	PRP	denotes	It
T1873	202-204	NN	denotes	RA
T1872	199-201	IN	denotes	in
T1871	193-198	NN	denotes	NF-κB
T1870	184-192	VB	denotes	activate
T1869	179-183	WDT	denotes	that
T1868	170-178	NN	denotes	triggers
T1867	160-169	JJ	denotes	molecular
T1866	156-159	DT	denotes	the
T1865	153-155	IN	denotes	of
T1864	138-152	NN	denotes	identification
T1863	134-137	DT	denotes	the
T1862	129-133	IN	denotes	with
T1861	123-128	NN	denotes	deals
T1860	114-122	NN	denotes	research
T1859	109-113	JJ	denotes	much
T1858	107-108	-COMMA-	denotes	,
T1857	105-107	NN	denotes	RA
T1856	102-104	IN	denotes	in
T1855	89-101	NN	denotes	inflammation
T1854	86-88	IN	denotes	of
T1853	78-85	NN	denotes	process
T1852	74-77	DT	denotes	the
T1851	71-73	TO	denotes	to
T1850	63-70	JJ	denotes	central
T1849	60-62	VB	denotes	is
T1848	54-59	NN	denotes	NF-κB
T1847	48-53	IN	denotes	Since
T2417	3499-3501	VB	denotes	be
T2416	3496-3498	TO	denotes	to
T2415	3486-3495	VB	denotes	suggested
T2414	3481-3485	VB	denotes	been
T2413	3476-3480	VB	denotes	have
T2412	3472-3475	CC	denotes	and
T2411	3470-3471	-COMMA-	denotes	,
T2410	3465-3470	NN	denotes	fluid
T2409	3456-3464	JJ	denotes	synovial
T2408	3453-3455	NN	denotes	RA
T2407	3450-3452	IN	denotes	in
T2406	3442-3449	JJ	denotes	present
T2405	3431-3441	RB	denotes	abundantly
T2404	3426-3430	RB	denotes	also
T2403	3422-3425	VB	denotes	are
T2402	3420-3421	-COMMA-	denotes	,
T2401	3412-3420	NN	denotes	proteins
T2400	3396-3411	JJ	denotes	calcium-binding
T2399	3393-3395	IN	denotes	of
T2398	3386-3392	NN	denotes	family
T2397	3381-3385	NN	denotes	S100
T2396	3377-3380	DT	denotes	the
T2395	3374-3376	TO	denotes	to
T2394	3364-3373	VB	denotes	belonging
T2393	3354-3363	NN	denotes	molecules
T2392	3346-3353	NN	denotes	pattern
T2391	3336-3345	JJ	denotes	molecular
T2390	3318-3335	JJ	denotes	damage-associated
T2389	3316-3317	-COMMA-	denotes	,
T2388	3314-3316	CD	denotes	14
T2387	3306-3313	NN	denotes	protein
T2386	3290-3305	JJ	denotes	myeloid-related
T2385	3286-3289	CC	denotes	and
T2384	3284-3285	CD	denotes	8
T2383	3276-3283	NN	denotes	protein
T2382	3260-3275	JJ	denotes	Myeloid-related
T2381	3257-3258	-RRB-	denotes	]
T2380	3255-3257	CD	denotes	16
T2379	3254-3255	-LRB-	denotes	[
T2378	3249-3253	NN	denotes	mice
T2377	3246-3248	IN	denotes	in
T2376	3236-3245	NN	denotes	arthritis
T2375	3219-3235	JJ	denotes	collagen-induced
T2374	3211-3218	IN	denotes	against
T2373	3203-3210	NN	denotes	protect
T2372	3197-3202	NN	denotes	HMGB1
T2371	3194-3196	IN	denotes	of
T2370	3187-3193	NN	denotes	domain
T2369	3182-3186	NN	denotes	BoxA
T2368	3169-3181	JJ	denotes	antagonistic
T2367	3165-3168	DT	denotes	the
T2366	3162-3164	CC	denotes	or
T2365	3151-3161	NN	denotes	antibodies
T2364	3138-3150	VB	denotes	neutralising
T2363	3132-3137	NN	denotes	HMGB1
T2362	3128-3131	CC	denotes	and
T2361	3121-3127	NN	denotes	tissue
T2360	3112-3120	JJ	denotes	synovial
T2359	3109-3111	NN	denotes	RA
T2358	3106-3108	IN	denotes	in
T2357	3096-3105	VB	denotes	increased
T2356	3093-3095	VB	denotes	is
T2355	3087-3092	NN	denotes	HMGB1
T2354	3076-3085	NN	denotes	pathology
T2353	3073-3075	NN	denotes	RA
T2352	3070-3072	IN	denotes	in
T2351	3061-3069	VB	denotes	involved
T2350	3053-3060	NN	denotes	ligands
T2349	3048-3052	NN	denotes	TLR4
T2348	3037-3047	JJ	denotes	endogenous
T2347	3028-3036	JJ	denotes	putative
T2346	3023-3027	RB	denotes	most
T2345	3019-3022	DT	denotes	the
T2344	3016-3018	IN	denotes	of
T2343	3012-3015	CD	denotes	one
T2342	3009-3011	VB	denotes	is
T2341	3007-3008	-COMMA-	denotes	,
T2340	3002-3007	NN	denotes	cells
T2339	2993-3001	JJ	denotes	necrotic
T2338	2990-2992	IN	denotes	by
T2337	2981-2989	VB	denotes	released
T2336	2971-2980	RB	denotes	passively
T2335	2968-2970	CC	denotes	or
T2334	2956-2967	NN	denotes	macrophages
T2333	2953-2955	IN	denotes	by
T2332	2944-2952	VB	denotes	secreted
T2331	2935-2943	RB	denotes	actively
T2330	2932-2934	VB	denotes	be
T2329	2928-2931	MD	denotes	can
T2328	2923-2927	WDT	denotes	that
T2327	2913-2922	NN	denotes	component
T2326	2903-2912	NN	denotes	chromatin
T2325	2893-2902	VB	denotes	conserved
T2324	2886-2892	RB	denotes	highly
T2323	2884-2885	DT	denotes	a
T2322	2882-2883	-COMMA-	denotes	,
T2321	2881-2882	-RRB-	denotes	)
T2320	2876-2881	NN	denotes	HMGB1
T2319	2875-2876	-LRB-	denotes	(
T2318	2873-2874	CD	denotes	1
T2317	2865-2872	NN	denotes	protein
T2316	2853-2864	JJ	denotes	chromosomal
T2315	2849-2852	NN	denotes	box
T2314	2843-2848	NN	denotes	group
T2313	2834-2842	NN	denotes	mobility
T2312	2829-2833	JJ	denotes	High
T2311	2820-2827	NN	denotes	disease
T2310	2816-2819	DT	denotes	the
T2309	2813-2815	IN	denotes	of
T2308	2800-2812	NN	denotes	pathogenesis
T2307	2796-2799	DT	denotes	the
T2306	2793-2795	IN	denotes	in
T2305	2783-2792	JJ	denotes	important
T2304	2777-2782	VB	denotes	being
T2303	2774-2776	IN	denotes	as
T2302	2761-2773	NN	denotes	inflammation
T2301	2747-2760	JJ	denotes	TLR-dependent
T2300	2738-2746	VB	denotes	identify
T2299	2730-2737	RB	denotes	clearly
T2298	2719-2729	NN	denotes	signalling
T2297	2715-2718	NN	denotes	TLR
T2296	2709-2714	VB	denotes	block
T2295	2706-2708	TO	denotes	to
T2294	2695-2705	NN	denotes	strategies
T2293	2692-2694	CC	denotes	or
T2292	2687-2691	NN	denotes	mice
T2291	2678-2686	NN	denotes	knockout
T2290	2674-2677	NN	denotes	TLR
T2289	2668-2673	VB	denotes	using
T2288	2661-2667	NN	denotes	models
T2287	2654-2660	NN	denotes	animal
T2286	2652-2653	-COMMA-	denotes	,
T2285	2644-2652	RB	denotes	Moreover
T2284	2634-2642	NN	denotes	patients
T2283	2631-2633	NN	denotes	RA
T2282	2628-2630	IN	denotes	of
T2281	2621-2627	NN	denotes	joints
T2280	2612-2620	JJ	denotes	inflamed
T2279	2608-2611	DT	denotes	the
T2278	2601-2607	IN	denotes	within
T2277	2593-2600	JJ	denotes	present
T2276	2589-2592	VB	denotes	are
T2275	2581-2588	NN	denotes	ligands
T2274	2570-2580	JJ	denotes	endogenous
T2273	2562-2569	JJ	denotes	various
T2272	2558-2561	CC	denotes	and
T2237	2352-2354	IN	denotes	of
T2236	2346-2351	NN	denotes	group
T2235	2344-2345	DT	denotes	a
T2234	2342-2343	-COLON-	denotes	-
T2233	2334-2341	NN	denotes	ligands
T2232	2323-2333	JJ	denotes	endogenous
T2231	2320-2322	IN	denotes	of
T2230	2313-2319	NN	denotes	number
T2229	2302-2312	VB	denotes	increasing
T2228	2299-2301	DT	denotes	an
T2227	2297-2298	-COMMA-	denotes	,
T2226	2290-2297	NN	denotes	ligands
T2225	2280-2289	JJ	denotes	microbial
T2224	2277-2279	TO	denotes	to
T2223	2268-2276	NN	denotes	addition
T2222	2265-2267	IN	denotes	In
T2221	2261-2263	NN	denotes	RA
T2220	2258-2260	IN	denotes	in
T2219	2245-2257	NN	denotes	inflammation
T2218	2229-2244	JJ	denotes	NF-κB-dependent
T2217	2220-2228	VB	denotes	inducing
T2216	2216-2219	IN	denotes	for
T2215	2205-2215	NN	denotes	candidates
T2214	2195-2204	JJ	denotes	potential
T2213	2191-2194	VB	denotes	are
T2212	2187-2190	CC	denotes	and
T2211	2178-2186	NN	denotes	diseases
T2210	2167-2177	JJ	denotes	autoimmune
T2209	2164-2166	IN	denotes	of
T2208	2156-2163	NN	denotes	variety
T2207	2154-2155	DT	denotes	a
T2206	2151-2153	IN	denotes	in
T2205	2140-2150	VB	denotes	implicated
T2204	2135-2139	VB	denotes	been
T2203	2130-2134	VB	denotes	have
T2202	2128-2129	-RRB-	denotes	)
T2201	2124-2128	NN	denotes	TLRs
T2200	2123-2124	-LRB-	denotes	(
T2199	2113-2122	NN	denotes	receptors
T2198	2103-2112	JJ	denotes	Toll-like
T2197	2100-2101	-RRB-	denotes	]
T2196	2098-2100	CD	denotes	13
T2195	2097-2098	-LRB-	denotes	[
T2194	2094-2096	NN	denotes	RA
T2193	2084-2093	VB	denotes	including
T2192	2071-2083	NN	denotes	inflammation
T2191	2063-2070	JJ	denotes	chronic
T2190	2060-2062	IN	denotes	of
T2189	2054-2059	NN	denotes	sites
T2188	2051-2053	IN	denotes	at
T2187	2041-2050	NN	denotes	formation
T2186	2035-2040	NN	denotes	organ
T2185	2026-2034	JJ	denotes	lymphoid
T2184	2017-2025	JJ	denotes	tertiary
T2183	2014-2016	IN	denotes	in
T2182	2003-2013	VB	denotes	implicated
T2181	1998-2002	VB	denotes	been
T2180	1994-1997	VB	denotes	has
T2179	1983-1993	NN	denotes	signalling
T2178	1974-1982	NN	denotes	receptor
T2177	1972-1973	NN	denotes	β
T2176	1960-1971	NN	denotes	lymphotoxin
T2175	1958-1959	-COMMA-	denotes	,
T2174	1951-1958	RB	denotes	Finally
T2173	1948-1949	-RRB-	denotes	]
T2172	1946-1948	CD	denotes	13
T2171	1945-1946	-LRB-	denotes	[
T2170	1942-1944	NN	denotes	RA
T2169	1934-1941	VB	denotes	counter
T2168	1931-1933	TO	denotes	to
T2167	1921-1930	VB	denotes	developed
T2166	1916-1920	VB	denotes	been
T2165	1911-1915	VB	denotes	have
T2164	1906-1910	NN	denotes	BAFF
T2163	1903-1905	IN	denotes	of
T2162	1891-1902	NN	denotes	antagonists
T2161	1887-1890	CC	denotes	and
T2160	1885-1886	-COMMA-	denotes	,
T2159	1883-1885	NN	denotes	RA
T2158	1879-1882	IN	denotes	for
T2157	1864-1878	JJ	denotes	characteristic
T2156	1859-1863	RB	denotes	also
T2155	1856-1858	VB	denotes	is
T2154	1854-1855	-COMMA-	denotes	,
T2153	1843-1854	NN	denotes	lymphocytes
T2152	1841-1842	NN	denotes	B
T2151	1831-1840	VB	denotes	producing
T2150	1817-1830	NN	denotes	autoantibody-
T2149	1814-1816	IN	denotes	of
T2148	1805-1813	NN	denotes	survival
T2147	1801-1804	DT	denotes	the
T2146	1792-1800	VB	denotes	allowing
T2145	1790-1791	-COMMA-	denotes	,
T2144	1789-1790	-RRB-	denotes	)
T2143	1785-1789	NN	denotes	BAFF
T2142	1784-1785	-LRB-	denotes	(
T2141	1777-1783	NN	denotes	factor
T2140	1766-1776	VB	denotes	activating
T2139	1759-1765	NN	denotes	B-cell
T2138	1752-1758	NN	denotes	member
T2137	1745-1751	NN	denotes	family
T2136	1736-1744	NN	denotes	receptor
T2135	1732-1735	NN	denotes	TNF
T2134	1728-1731	DT	denotes	the
T2133	1725-1727	IN	denotes	of
T2132	1714-1724	NN	denotes	expression
T2131	1705-1713	VB	denotes	Enhanced
T2130	1702-1703	-RRB-	denotes	]
T2129	1697-1702	CD	denotes	11,12
T2128	1696-1697	-LRB-	denotes	[
T2127	1688-1695	JJ	denotes	present
T2126	1680-1687	RB	denotes	already
T2125	1676-1679	VB	denotes	are
T2124	1665-1675	NN	denotes	antibodies
T2123	1654-1664	JJ	denotes	pathogenic
T2122	1650-1653	CC	denotes	and
T2121	1638-1649	VB	denotes	established
T2120	1635-1637	VB	denotes	is
T2119	1627-1634	NN	denotes	disease
T2118	1622-1626	RB	denotes	once
T2117	1613-1621	VB	denotes	required
T2116	1609-1612	RB	denotes	not
T2115	1605-1608	VB	denotes	are
T2114	1601-1604	CC	denotes	but
T2113	1599-1600	-COMMA-	denotes	,
T2112	1590-1599	NN	denotes	induction
T2111	1580-1589	NN	denotes	arthritis
T2110	1577-1579	IN	denotes	of
T2109	1570-1576	NN	denotes	stages
T2108	1562-1569	JJ	denotes	initial
T2107	1558-1561	DT	denotes	the
T2106	1555-1557	IN	denotes	at
T2105	1545-1554	JJ	denotes	important
T2104	1542-1544	VB	denotes	be
T2103	1538-1541	MD	denotes	may
T2102	1530-1537	NN	denotes	signals
T2101	1525-1529	NN	denotes	CD40
T2100	1520-1524	IN	denotes	that
T2099	1509-1519	NN	denotes	conclusion
T2098	1505-1508	DT	denotes	the
T2097	1502-1504	TO	denotes	to
T2096	1498-1501	VB	denotes	led
T2095	1487-1497	NN	denotes	antibodies
T2094	1476-1486	JJ	denotes	anti-CD154
T2093	1473-1475	CC	denotes	or
T2092	1463-1472	NN	denotes	anti-CD40
T2091	1450-1462	JJ	denotes	antagonistic
T2090	1445-1449	IN	denotes	with
T2089	1437-1444	NN	denotes	studies
T2088	1435-1436	-COMMA-	denotes	,
T2087	1428-1435	RB	denotes	However
T2086	1415-1426	NN	denotes	destruction
T2085	1409-1414	JJ	denotes	joint
T2084	1406-1408	TO	denotes	to
T2083	1394-1405	VB	denotes	contributes
T2082	1388-1393	WDT	denotes	which
T2081	1386-1387	-COMMA-	denotes	,
T2080	1376-1386	NN	denotes	chemokines
T2079	1372-1375	CC	denotes	and
T2078	1362-1371	NN	denotes	cytokines
T2077	1346-1361	JJ	denotes	proinflammatory
T2076	1343-1345	IN	denotes	of
T2075	1333-1342	NN	denotes	secretion
T2074	1329-1332	CC	denotes	and
T2073	1315-1328	NN	denotes	proliferation
T2072	1304-1314	NN	denotes	fibroblast
T2071	1301-1303	IN	denotes	in
T2070	1291-1300	VB	denotes	resulting
T2069	1280-1290	NN	denotes	activation
T2068	1274-1279	NN	denotes	NF-κB
T2067	1265-1273	VB	denotes	triggers
T2066	1263-1264	-COMMA-	denotes	,
T2065	1258-1263	NN	denotes	cells
T2064	1256-1257	NN	denotes	T
T2063	1251-1255	JJ	denotes	CD4+
T2062	1241-1250	VB	denotes	activated
T2061	1238-1240	IN	denotes	of
T2060	1230-1237	NN	denotes	surface
T2059	1226-1229	DT	denotes	the
T2058	1223-1225	IN	denotes	on
T2057	1213-1222	VB	denotes	expressed
T2056	1201-1212	RB	denotes	transiently
T2055	1198-1200	VB	denotes	is
T2054	1192-1197	WDT	denotes	which
T2053	1190-1191	-COMMA-	denotes	,
T2052	1189-1190	-RRB-	denotes	)
T2051	1184-1189	NN	denotes	CD154
T2050	1183-1184	-LRB-	denotes	(
T2049	1176-1182	NN	denotes	ligand
T2048	1171-1175	NN	denotes	CD40
T2271	2550-2557	NN	denotes	tissues
T2270	2541-2549	JJ	denotes	synovial
T2269	2538-2540	NN	denotes	RA
T2268	2535-2537	IN	denotes	in
T2267	2525-2534	VB	denotes	expressed
T2266	2521-2524	VB	denotes	are
T2265	2516-2520	NN	denotes	TLRs
T2264	2513-2514	-RRB-	denotes	)
T2263	2512-2513	-RRB-	denotes	]
T2262	2507-2512	CD	denotes	14,15
T2261	2506-2507	-LRB-	denotes	[
T2260	2503-2505	IN	denotes	in
T2259	2494-2502	VB	denotes	reviewed
T2258	2493-2494	-LRB-	denotes	(
T2257	2480-2492	NN	denotes	inflammation
T2256	2472-2479	JJ	denotes	sterile
T2255	2462-2471	JJ	denotes	so-called
T2254	2453-2461	VB	denotes	inducing
T2253	2448-2452	NN	denotes	TLRs
T2252	2445-2447	IN	denotes	of
T2251	2434-2444	NN	denotes	activators
T2250	2424-2433	NN	denotes	candidate
T2249	2421-2423	IN	denotes	as
T2248	2412-2420	VB	denotes	reported
T2247	2407-2411	VB	denotes	been
T2246	2402-2406	VB	denotes	have
T2245	2400-2401	-COLON-	denotes	-
T2244	2394-2399	NN	denotes	cells
T2243	2390-2393	CC	denotes	and
T2242	2382-2389	NN	denotes	tissues
T2241	2377-2381	NN	denotes	host
T2240	2372-2376	IN	denotes	from
T2239	2364-2371	VB	denotes	derived
T2238	2355-2363	NN	denotes	proteins
R1933	T2438	T2437	arg1Of	pathology,RA
R1934	T2442	T2440	arg1Of	components,extracellular
R1935	T2442	T2441	arg1Of	components,matrix
R1314	T1848	T1849	arg1Of	NF-κB,is
R1315	T1848	T1850	arg1Of	NF-κB,central
R1316	T1849	T1847	arg2Of	is,Since
R1317	T1849	T1862	arg1Of	is,with
R1318	T1850	T1849	arg2Of	central,is
R1319	T1850	T1851	arg1Of	central,to
R1320	T1853	T1851	arg2Of	process,to
R1321	T1853	T1852	arg1Of	process,the
R1322	T1853	T1854	arg1Of	process,of
R1323	T1853	T1856	arg1Of	process,in
R1324	T1853	T1858	arg1Of	process,","
R1325	T1855	T1854	arg2Of	inflammation,of
R1326	T1857	T1856	arg2Of	RA,in
R1327	T1861	T1858	arg2Of	deals,","
R1328	T1861	T1859	arg1Of	deals,much
R1329	T1861	T1860	arg1Of	deals,research
R1330	T1864	T1862	arg2Of	identification,with
R1331	T1864	T1863	arg1Of	identification,the
R1332	T1864	T1865	arg1Of	identification,of
R1333	T1868	T1865	arg2Of	triggers,of
R1334	T1868	T1866	arg1Of	triggers,the
R1335	T1868	T1867	arg1Of	triggers,molecular
R1336	T1869	T1870	arg1Of	that,activate
R1337	T1870	T1847	arg1Of	activate,Since
R1338	T1870	T1872	arg1Of	activate,in
R1339	T1871	T1870	arg2Of	NF-κB,activate
R1340	T1873	T1872	arg2Of	RA,in
R1341	T1874	T1875	arg1Of	It,is
R1342	T1874	T1877	arg2Of	It,accepted
R1343	T1877	T1875	arg2Of	accepted,is
R1344	T1877	T1876	arg1Of	accepted,well
R1345	T1880	T1879	arg1Of	cytokines,proinflammatory
R1346	T1880	T1882	arg1Of	cytokines,as
R1347	T1880	T1886	arg1Of	cytokines,play
R1348	T1882	T1881	arg1Of	as,such
R1349	T1883	T1884	arg1Of	TNF,and
R1350	T1884	T1882	arg2Of	and,as
R1351	T1885	T1884	arg2Of	IL-1,and
R1352	T1886	T1891	arg1Of	play,and
R1353	T1889	T1886	arg2Of	role,play
R1354	T1889	T1887	arg1Of	role,an
R1355	T1889	T1888	arg1Of	role,important
R1356	T1891	T1877	arg3Of	and,accepted
R1357	T1891	T1878	arg1Of	and,that
R1358	T1891	T1890	arg1Of	and,","
R1359	T1892	T1893	arg1Of	administration,of
R1360	T1892	T1896	arg1Of	administration,is
R1361	T1895	T1893	arg2Of	antagonists,of
R1362	T1895	T1894	arg1Of	antagonists,TNF
R1363	T1896	T1891	arg2Of	is,and
R1364	T1899	T1896	arg2Of	treatment,is
R1365	T1899	T1897	arg1Of	treatment,an
R1366	T1899	T1898	arg1Of	treatment,effective
R1367	T1899	T1900	arg1Of	treatment,for
R1368	T1902	T1900	arg2Of	RA,for
R1369	T1902	T1901	arg1Of	RA,severe
R1370	T1902	T1903	arg1Of	RA,(
R1371	T1904	T1903	arg2Of	reviewed,(
R1372	T1904	T1905	arg1Of	reviewed,in
R1373	T1904	T1906	arg1Of	reviewed,[
R1374	T1907	T1906	arg2Of	9,[
R1375	T1908	T1906	arg3Of	],[
R1376	T1909	T1903	arg3Of	),(
R1377	T1910	T1911	arg1Of	TNF,and
R1378	T1911	T1913	arg1Of	and,are
R1379	T1912	T1911	arg2Of	IL-1,and
R1380	T1913	T1920	arg1Of	are,and
R1381	T1916	T1915	arg1Of	potent,very
R1382	T1917	T1913	arg2Of	activators,are
R1383	T1917	T1914	arg1Of	activators,both
R1384	T1917	T1916	arg1Of	activators,potent
R1385	T1917	T1918	arg1Of	activators,of
R1386	T1919	T1918	arg2Of	NF-κB,of
R1387	T1921	T1922	arg1Of	it,can
R1388	T1921	T1923	arg1Of	it,be
R1389	T1921	T1924	arg2Of	it,expected
R1390	T1924	T1920	arg2Of	expected,and
R1391	T1924	T1922	arg2Of	expected,can
R1392	T1924	T1923	arg2Of	expected,be
R1393	T1927	T1926	arg1Of	activation,NF-κB
R1394	T1927	T1928	arg1Of	activation,by
R1395	T1927	T1931	arg1Of	activation,mediates
R1396	T1930	T1928	arg2Of	cytokines,by
R1397	T1930	T1929	arg1Of	cytokines,these
R1398	T1931	T1924	arg3Of	mediates,expected
R1399	T1931	T1925	arg1Of	mediates,that
R1400	T1932	T1931	arg2Of	most,mediates
R1401	T1932	T1933	arg1Of	most,of
R1402	T1936	T1933	arg2Of	activities,of
R1403	T1936	T1934	arg1Of	activities,their
R1404	T1936	T1935	arg1Of	activities,pro-inflammatory
R1405	T1936	T1937	arg1Of	activities,in
R1406	T1938	T1937	arg2Of	RA,in
R1407	T1938	T1939	arg1Of	RA,(
R1408	T1940	T1939	arg2Of	reviewed,(
R1409	T1940	T1941	arg1Of	reviewed,in
R1410	T1940	T1942	arg1Of	reviewed,[
R1411	T1943	T1942	arg2Of	3,[
R1412	T1944	T1942	arg3Of	],[
R1413	T1945	T1939	arg3Of	),(
R1414	T1947	T1946	arg1Of	activation,NF-κB
R1415	T1947	T1948	arg1Of	activation,by
R1416	T1947	T1963	arg1Of	activation,is
R1417	T1947	T1964	arg1Of	activation,important
R1418	T1950	T1948	arg2Of	activator,by
R1419	T1950	T1949	arg1Of	activator,receptor
R1420	T1950	T1951	arg1Of	activator,of
R1421	T1952	T1951	arg2Of	NF-κB,of
R1422	T1952	T1953	arg1Of	NF-κB,(
R1423	T1952	T1956	arg1Of	NF-κB,","
R1424	T1954	T1953	arg2Of	RANK,(
R1425	T1955	T1953	arg3Of	),(
R1426	T1961	T1956	arg2Of	member,","
R1427	T1961	T1957	arg1Of	member,a
R1428	T1961	T1958	arg1Of	member,TNF
R1429	T1961	T1959	arg1Of	member,receptor
R1430	T1961	T1960	arg1Of	member,family
R1431	T1963	T1962	arg1Of	is,","
R1432	T1963	T1968	arg1Of	is,and
R1433	T1964	T1963	arg2Of	important,is
R1434	T1964	T1965	arg1Of	important,for
R1435	T1966	T1965	arg2Of	osteoclastogenesis,for
R1436	T1968	T1967	arg1Of	and,","
R1437	T1969	T1970	arg1Of	defects,in
R1438	T1969	T1974	arg1Of	defects,are
R1439	T1969	T1975	arg1Of	defects,likely
R1440	T1969	T1977	arg1Of	defects,be
R1441	T1969	T1978	arg2Of	defects,involved
R1442	T1973	T1970	arg2Of	signalling,in
R1443	T1973	T1971	arg1Of	signalling,proper
R1444	T1973	T1972	arg1Of	signalling,RANK-NF-κB
R1445	T1974	T1968	arg2Of	are,and
R1446	T1975	T1974	arg2Of	likely,are
R1447	T1978	T1975	arg2Of	involved,likely
R1448	T1978	T1976	arg1Of	involved,to
R1449	T1978	T1977	arg2Of	involved,be
R1450	T1978	T1979	arg1Of	involved,in
R1451	T1981	T1980	arg1Of	pathology,RA
R1452	T1981	T1982	arg1Of	pathology,and
R1453	T1982	T1979	arg2Of	and,in
R1454	T1982	T1985	arg2Of	and,associated
R1455	T1984	T1982	arg2Of	diseases,and
R1456	T1984	T1983	arg1Of	diseases,other
R1457	T1985	T1986	arg1Of	associated,with
R1458	T1988	T1986	arg2Of	loss,with
R1459	T1988	T1987	arg1Of	loss,bone
R1460	T1988	T1989	arg1Of	loss,[
R1461	T1990	T1989	arg2Of	7,[
R1462	T1991	T1989	arg3Of	],[
R1463	T1992	T1993	arg1Of	CD40,is
R1464	T1998	T1993	arg2Of	member,is
R1465	T1998	T1994	arg1Of	member,another
R1466	T1998	T1995	arg1Of	member,TNF
R1467	T1998	T1996	arg1Of	member,receptor
R1468	T1998	T1997	arg1Of	member,family
R1469	T1998	T1999	arg1Of	member,that
R1470	T1998	T2000	arg1Of	member,is
R1471	T1998	T2002	arg2Of	member,expressed
R1472	T1998	T2034	arg1Of	member,can
R1473	T1998	T2035	arg1Of	member,be
R1474	T1998	T2036	arg2Of	member,upregulated
R1475	T2002	T2000	arg2Of	expressed,is
R1476	T2002	T2001	arg1Of	expressed,functionally
R1477	T2002	T2003	arg1Of	expressed,on
R1478	T2002	T2033	arg1Of	expressed,and
R1479	T2005	T2003	arg2Of	variety,on
R1480	T2005	T2004	arg1Of	variety,a
R1481	T2005	T2006	arg1Of	variety,of
R1482	T2008	T2007	arg1Of	types,cell
R1483	T2008	T2009	arg1Of	types,","
R1484	T2008	T2010	arg1Of	types,including
R1485	T2008	T2023	arg1Of	types,","
R1486	T2013	T2010	arg2Of	fibroblasts,including
R1487	T2013	T2011	arg1Of	fibroblasts,smooth
R1488	T2013	T2012	arg1Of	fibroblasts,muscle
R1489	T2013	T2014	arg1Of	fibroblasts,from
R1490	T2015	T2016	arg1Of	normal,and
R1491	T2017	T2016	arg2Of	RA,and
R1492	T2018	T2015	arg1Of	patients,normal
R1493	T2018	T2017	arg1Of	patients,RA
R1494	T2018	T2019	arg1Of	patients,and
R1495	T2019	T2014	arg2Of	and,from
R1496	T2022	T2019	arg2Of	cells,and
R1497	T2022	T2020	arg1Of	cells,RA
R1498	T2022	T2021	arg1Of	cells,synovial
R1499	T2023	T2006	arg2Of	",",of
R1500	T2025	T2024	arg1Of	cells,B
R1501	T2025	T2026	arg1Of	cells,","
R1502	T2026	T2029	arg1Of	",",and
R1503	T2027	T2026	arg2Of	macrophages,","
R1504	T2029	T2023	arg2Of	and,","
R1505	T2029	T2028	arg1Of	and,","
R1506	T2031	T2029	arg2Of	cells,and
R1507	T2031	T2030	arg1Of	cells,dendritic
R1508	T2033	T2032	arg1Of	and,","
R1509	T2036	T2033	arg2Of	upregulated,and
R1510	T2036	T2034	arg2Of	upregulated,can
R1511	T2036	T2035	arg2Of	upregulated,be
R1512	T2039	T2036	arg1Of	cytokines,upregulated
R1513	T2039	T2037	arg2Of	cytokines,by
R1514	T2039	T2038	arg1Of	cytokines,proinflammatory
R1515	T2039	T2040	arg1Of	cytokines,including
R1516	T2041	T2040	arg2Of	TNF,including
R1517	T2041	T2042	arg1Of	TNF,[
R1518	T2043	T2042	arg2Of	10,[
R1519	T2044	T2042	arg3Of	],[
R1520	T2045	T2046	arg1Of	Binding,of
R1521	T2045	T2067	arg1Of	Binding,triggers
R1522	T2049	T2046	arg2Of	ligand,of
R1523	T2049	T2047	arg1Of	ligand,the
R1524	T2049	T2048	arg1Of	ligand,CD40
R1525	T2049	T2050	arg1Of	ligand,(
R1526	T2049	T2053	arg1Of	ligand,","
R1527	T2049	T2054	arg1Of	ligand,which
R1528	T2049	T2055	arg1Of	ligand,is
R1529	T2049	T2057	arg2Of	ligand,expressed
R1530	T2051	T2050	arg2Of	CD154,(
R1531	T2052	T2050	arg3Of	),(
R1532	T2057	T2055	arg2Of	expressed,is
R1533	T2057	T2056	arg1Of	expressed,transiently
R1534	T2057	T2058	arg1Of	expressed,on
R1535	T2060	T2058	arg2Of	surface,on
R1536	T2060	T2059	arg1Of	surface,the
R1537	T2060	T2061	arg1Of	surface,of
R1538	T2065	T2061	arg2Of	cells,of
R1539	T2065	T2062	arg2Of	cells,activated
R1540	T2065	T2063	arg1Of	cells,CD4+
R1541	T2065	T2064	arg1Of	cells,T
R1542	T2067	T2066	arg1Of	triggers,","
R1543	T2069	T2067	arg2Of	activation,triggers
R1544	T2069	T2068	arg1Of	activation,NF-κB
R1545	T2069	T2070	arg1Of	activation,resulting
R1546	T2070	T2071	arg1Of	resulting,in
R1547	T2073	T2072	arg1Of	proliferation,fibroblast
R1548	T2073	T2074	arg1Of	proliferation,and
R1549	T2074	T2071	arg2Of	and,in
R1550	T2074	T2081	arg1Of	and,","
R1551	T2074	T2082	arg1Of	and,which
R1552	T2074	T2083	arg1Of	and,contributes
R1553	T2075	T2074	arg2Of	secretion,and
R1554	T2075	T2076	arg1Of	secretion,of
R1555	T2078	T2077	arg1Of	cytokines,proinflammatory
R1556	T2078	T2079	arg1Of	cytokines,and
R1557	T2079	T2076	arg2Of	and,of
R1558	T2080	T2079	arg2Of	chemokines,and
R1559	T2083	T2084	arg1Of	contributes,to
R1560	T2086	T2084	arg2Of	destruction,to
R1561	T2086	T2085	arg1Of	destruction,joint
R1562	T2089	T2090	arg1Of	studies,with
R1563	T2089	T2096	arg1Of	studies,led
R1564	T2089	T2115	arg1Of	studies,are
R1565	T2089	T2117	arg2Of	studies,required
R1566	T2092	T2091	arg1Of	anti-CD40,antagonistic
R1567	T2092	T2093	arg1Of	anti-CD40,or
R1568	T2093	T2090	arg2Of	or,with
R1569	T2095	T2093	arg2Of	antibodies,or
R1570	T2095	T2094	arg1Of	antibodies,anti-CD154
R1571	T2096	T2097	arg1Of	led,to
R1572	T2096	T2114	arg1Of	led,but
R1573	T2099	T2097	arg2Of	conclusion,to
R1574	T2099	T2098	arg1Of	conclusion,the
R1575	T2102	T2101	arg1Of	signals,CD40
R1576	T2102	T2103	arg1Of	signals,may
R1577	T2102	T2104	arg1Of	signals,be
R1578	T2102	T2105	arg1Of	signals,important
R1579	T2104	T2099	arg2Of	be,conclusion
R1580	T2104	T2100	arg1Of	be,that
R1581	T2104	T2103	arg2Of	be,may
R1582	T2105	T2104	arg2Of	important,be
R1583	T2105	T2106	arg1Of	important,at
R1584	T2109	T2106	arg2Of	stages,at
R1585	T2109	T2107	arg1Of	stages,the
R1586	T2109	T2108	arg1Of	stages,initial
R1587	T2109	T2110	arg1Of	stages,of
R1588	T2112	T2110	arg2Of	induction,of
R1589	T2112	T2111	arg1Of	induction,arthritis
R1590	T2114	T2087	arg1Of	but,However
R1591	T2114	T2088	arg1Of	but,","
R1592	T2114	T2113	arg1Of	but,","
R1593	T2117	T2114	arg2Of	required,but
R1594	T2117	T2115	arg2Of	required,are
R1595	T2117	T2116	arg1Of	required,not
R1596	T2117	T2118	arg1Of	required,once
R1597	T2119	T2120	arg1Of	disease,is
R1598	T2119	T2121	arg2Of	disease,established
R1599	T2121	T2120	arg2Of	established,is
R1600	T2121	T2122	arg1Of	established,and
R1601	T2122	T2118	arg2Of	and,once
R1602	T2124	T2123	arg1Of	antibodies,pathogenic
R1603	T2124	T2125	arg1Of	antibodies,are
R1604	T2124	T2127	arg1Of	antibodies,present
R1605	T2125	T2122	arg2Of	are,and
R1606	T2125	T2126	arg1Of	are,already
R1607	T2125	T2128	arg1Of	are,[
R1608	T2127	T2125	arg2Of	present,are
R1609	T2129	T2128	arg2Of	"11,12",[
R1610	T2130	T2128	arg3Of	],[
R1611	T2132	T2131	arg2Of	expression,Enhanced
R1612	T2132	T2133	arg1Of	expression,of
R1613	T2132	T2155	arg1Of	expression,is
R1614	T2132	T2157	arg1Of	expression,characteristic
R1615	T2139	T2133	arg2Of	B-cell,of
R1616	T2139	T2134	arg1Of	B-cell,the
R1617	T2139	T2135	arg1Of	B-cell,TNF
R1618	T2139	T2136	arg1Of	B-cell,receptor
R1619	T2139	T2137	arg1Of	B-cell,family
R1620	T2139	T2138	arg1Of	B-cell,member
R1621	T2139	T2140	arg1Of	B-cell,activating
R1622	T2140	T2145	arg1Of	activating,","
R1623	T2140	T2146	modOf	activating,allowing
R1624	T2141	T2140	arg2Of	factor,activating
R1625	T2141	T2142	arg1Of	factor,(
R1626	T2143	T2142	arg2Of	BAFF,(
R1627	T2144	T2142	arg3Of	),(
R1628	T2148	T2146	arg2Of	survival,allowing
R1629	T2148	T2147	arg1Of	survival,the
R1630	T2148	T2149	arg1Of	survival,of
R1631	T2148	T2151	arg1Of	survival,producing
R1632	T2150	T2149	arg2Of	autoantibody-,of
R1633	T2153	T2151	arg2Of	lymphocytes,producing
R1634	T2153	T2152	arg1Of	lymphocytes,B
R1635	T2155	T2154	arg1Of	is,","
R1636	T2155	T2156	arg1Of	is,also
R1637	T2155	T2161	arg1Of	is,and
R1638	T2157	T2155	arg2Of	characteristic,is
R1639	T2157	T2158	arg1Of	characteristic,for
R1640	T2159	T2158	arg2Of	RA,for
R1641	T2161	T2160	arg1Of	and,","
R1642	T2162	T2163	arg1Of	antagonists,of
R1643	T2162	T2165	arg1Of	antagonists,have
R1644	T2162	T2166	arg1Of	antagonists,been
R1645	T2162	T2167	arg2Of	antagonists,developed
R1646	T2164	T2163	arg2Of	BAFF,of
R1647	T2167	T2161	arg2Of	developed,and
R1648	T2167	T2165	arg2Of	developed,have
R1649	T2167	T2166	arg2Of	developed,been
R1650	T2167	T2168	modOf	developed,to
R1651	T2169	T2168	arg1Of	counter,to
R1652	T2170	T2169	arg2Of	RA,counter
R1653	T2170	T2171	arg1Of	RA,[
R1654	T2172	T2171	arg2Of	13,[
R1655	T2173	T2171	arg3Of	],[
R1656	T2179	T2176	arg1Of	signalling,lymphotoxin
R1657	T2179	T2177	arg1Of	signalling,β
R1658	T2179	T2178	arg1Of	signalling,receptor
R1659	T2179	T2180	arg1Of	signalling,has
R1660	T2179	T2181	arg1Of	signalling,been
R1661	T2179	T2182	arg2Of	signalling,implicated
R1662	T2182	T2174	arg1Of	implicated,Finally
R1663	T2182	T2175	arg1Of	implicated,","
R1664	T2182	T2180	arg2Of	implicated,has
R1665	T2182	T2181	arg2Of	implicated,been
R1666	T2182	T2183	arg1Of	implicated,in
R1667	T2187	T2183	arg2Of	formation,in
R1668	T2187	T2184	arg1Of	formation,tertiary
R1669	T2187	T2185	arg1Of	formation,lymphoid
R1670	T2187	T2186	arg1Of	formation,organ
R1671	T2187	T2188	arg1Of	formation,at
R1672	T2189	T2188	arg2Of	sites,at
R1673	T2189	T2190	arg1Of	sites,of
R1674	T2192	T2190	arg2Of	inflammation,of
R1675	T2192	T2191	arg1Of	inflammation,chronic
R1676	T2192	T2193	arg1Of	inflammation,including
R1677	T2194	T2193	arg2Of	RA,including
R1678	T2194	T2195	arg1Of	RA,[
R1679	T2196	T2195	arg2Of	13,[
R1680	T2197	T2195	arg3Of	],[
R1681	T2199	T2198	arg1Of	receptors,Toll-like
R1682	T2199	T2200	arg1Of	receptors,(
R1683	T2199	T2203	arg1Of	receptors,have
R1684	T2199	T2204	arg1Of	receptors,been
R1685	T2199	T2205	arg2Of	receptors,implicated
R1686	T2199	T2213	arg1Of	receptors,are
R1687	T2201	T2200	arg2Of	TLRs,(
R1688	T2202	T2200	arg3Of	),(
R1689	T2205	T2203	arg2Of	implicated,have
R1690	T2205	T2204	arg2Of	implicated,been
R1691	T2205	T2206	arg1Of	implicated,in
R1692	T2205	T2212	arg1Of	implicated,and
R1693	T2208	T2206	arg2Of	variety,in
R1694	T2208	T2207	arg1Of	variety,a
R1695	T2208	T2209	arg1Of	variety,of
R1696	T2211	T2209	arg2Of	diseases,of
R1697	T2211	T2210	arg1Of	diseases,autoimmune
R1698	T2213	T2212	arg2Of	are,and
R1699	T2215	T2213	arg2Of	candidates,are
R1700	T2215	T2214	arg1Of	candidates,potential
R1701	T2215	T2216	arg1Of	candidates,for
R1702	T2217	T2216	arg2Of	inducing,for
R1703	T2217	T2220	arg1Of	inducing,in
R1704	T2219	T2217	arg2Of	inflammation,inducing
R1705	T2219	T2218	arg1Of	inflammation,NF-κB-dependent
R1706	T2221	T2220	arg2Of	RA,in
R1707	T2223	T2222	arg2Of	addition,In
R1708	T2223	T2224	arg1Of	addition,to
R1709	T2226	T2224	arg2Of	ligands,to
R1710	T2226	T2225	arg1Of	ligands,microbial
R1711	T2230	T2228	arg1Of	number,an
R1712	T2230	T2229	arg1Of	number,increasing
R1713	T2230	T2231	arg1Of	number,of
R1714	T2230	T2234	arg1Of	number,-
R1715	T2230	T2246	arg1Of	number,have
R1716	T2230	T2247	arg1Of	number,been
R1717	T2230	T2248	arg2Of	number,reported
R1718	T2233	T2231	arg2Of	ligands,of
R1719	T2233	T2232	arg1Of	ligands,endogenous
R1720	T2236	T2234	arg2Of	group,-
R1721	T2236	T2235	arg1Of	group,a
R1722	T2236	T2237	arg1Of	group,of
R1723	T2238	T2237	arg2Of	proteins,of
R1724	T2238	T2239	arg2Of	proteins,derived
R1725	T2239	T2240	arg1Of	derived,from
R1726	T2242	T2241	arg1Of	tissues,host
R1727	T2242	T2243	arg1Of	tissues,and
R1728	T2243	T2240	arg2Of	and,from
R1729	T2244	T2243	arg2Of	cells,and
R1730	T2244	T2245	arg1Of	cells,-
R1731	T2248	T2222	arg1Of	reported,In
R1732	T2248	T2227	arg1Of	reported,","
R1733	T2248	T2246	arg2Of	reported,have
R1734	T2248	T2247	arg2Of	reported,been
R1735	T2248	T2249	arg1Of	reported,as
R1736	T2251	T2249	arg2Of	activators,as
R1737	T2251	T2250	arg1Of	activators,candidate
R1738	T2251	T2252	arg1Of	activators,of
R1739	T2253	T2252	arg2Of	TLRs,of
R1740	T2253	T2254	arg1Of	TLRs,inducing
R1741	T2257	T2254	arg2Of	inflammation,inducing
R1742	T2257	T2255	arg1Of	inflammation,so-called
R1743	T2257	T2256	arg1Of	inflammation,sterile
R1744	T2257	T2258	arg1Of	inflammation,(
R1745	T2259	T2258	arg2Of	reviewed,(
R1746	T2259	T2260	arg1Of	reviewed,in
R1747	T2259	T2261	arg1Of	reviewed,[
R1748	T2262	T2261	arg2Of	"14,15",[
R1749	T2263	T2261	arg3Of	],[
R1750	T2264	T2258	arg3Of	),(
R1751	T2265	T2266	arg1Of	TLRs,are
R1752	T2265	T2267	arg2Of	TLRs,expressed
R1753	T2267	T2266	arg2Of	expressed,are
R1754	T2267	T2268	arg1Of	expressed,in
R1755	T2269	T2268	arg2Of	RA,in
R1756	T2271	T2270	arg1Of	tissues,synovial
R1757	T2271	T2272	arg1Of	tissues,and
R1758	T2272	T2276	arg1Of	and,are
R1759	T2272	T2277	arg1Of	and,present
R1760	T2275	T2272	arg2Of	ligands,and
R1761	T2275	T2273	arg1Of	ligands,various
R1762	T2275	T2274	arg1Of	ligands,endogenous
R1763	T2276	T2266	modOf	are,are
R1764	T2277	T2276	arg2Of	present,are
R1765	T2277	T2278	arg1Of	present,within
R1766	T2281	T2278	arg2Of	joints,within
R1767	T2281	T2279	arg1Of	joints,the
R1768	T2281	T2280	arg1Of	joints,inflamed
R1769	T2281	T2282	arg1Of	joints,of
R1770	T2284	T2282	arg2Of	patients,of
R1771	T2284	T2283	arg1Of	patients,RA
R1772	T2288	T2287	arg1Of	models,animal
R1773	T2288	T2289	arg1Of	models,using
R1774	T2288	T2300	arg1Of	models,identify
R1775	T2292	T2290	arg1Of	mice,TLR
R1776	T2292	T2291	arg1Of	mice,knockout
R1777	T2292	T2293	arg1Of	mice,or
R1778	T2293	T2289	arg2Of	or,using
R1779	T2294	T2293	arg2Of	strategies,or
R1780	T2294	T2295	modOf	strategies,to
R1781	T2296	T2295	arg1Of	block,to
R1782	T2298	T2296	arg2Of	signalling,block
R1783	T2298	T2297	arg1Of	signalling,TLR
R1784	T2300	T2285	arg1Of	identify,Moreover
R1785	T2300	T2286	arg1Of	identify,","
R1786	T2300	T2299	arg1Of	identify,clearly
R1787	T2300	T2303	arg1Of	identify,as
R1788	T2302	T2300	arg2Of	inflammation,identify
R1789	T2302	T2301	arg1Of	inflammation,TLR-dependent
R1790	T2304	T2303	arg2Of	being,as
R1791	T2304	T2306	arg1Of	being,in
R1792	T2305	T2304	arg2Of	important,being
R1793	T2308	T2306	arg2Of	pathogenesis,in
R1794	T2308	T2307	arg1Of	pathogenesis,the
R1795	T2308	T2309	arg1Of	pathogenesis,of
R1796	T2311	T2309	arg2Of	disease,of
R1797	T2311	T2310	arg1Of	disease,the
R1798	T2317	T2312	arg1Of	protein,High
R1799	T2317	T2313	arg1Of	protein,mobility
R1800	T2317	T2314	arg1Of	protein,group
R1801	T2317	T2315	arg1Of	protein,box
R1802	T2317	T2316	arg1Of	protein,chromosomal
R1803	T2317	T2318	arg1Of	protein,1
R1804	T2317	T2319	arg1Of	protein,(
R1805	T2317	T2322	arg1Of	protein,","
R1806	T2317	T2342	arg1Of	protein,is
R1807	T2320	T2319	arg2Of	HMGB1,(
R1808	T2321	T2319	arg3Of	),(
R1809	T2325	T2324	arg1Of	conserved,highly
R1810	T2327	T2322	arg2Of	component,","
R1811	T2327	T2323	arg1Of	component,a
R1812	T2327	T2325	arg1Of	component,conserved
R1813	T2327	T2326	arg1Of	component,chromatin
R1814	T2327	T2328	arg1Of	component,that
R1815	T2327	T2329	arg1Of	component,can
R1816	T2327	T2330	arg1Of	component,be
R1817	T2327	T2332	arg2Of	component,secreted
R1818	T2327	T2337	arg2Of	component,released
R1819	T2332	T2335	arg1Of	secreted,or
R1820	T2334	T2332	arg1Of	macrophages,secreted
R1821	T2334	T2333	arg2Of	macrophages,by
R1822	T2335	T2329	arg2Of	or,can
R1823	T2335	T2330	arg2Of	or,be
R1824	T2335	T2331	arg1Of	or,actively
R1825	T2337	T2335	arg2Of	released,or
R1826	T2337	T2336	arg1Of	released,passively
R1827	T2340	T2337	arg1Of	cells,released
R1828	T2340	T2338	arg2Of	cells,by
R1829	T2340	T2339	arg1Of	cells,necrotic
R1830	T2342	T2341	arg1Of	is,","
R1831	T2343	T2342	arg2Of	one,is
R1832	T2343	T2344	arg1Of	one,of
R1833	T2348	T2346	arg1Of	endogenous,most
R1834	T2348	T2347	arg1Of	endogenous,putative
R1835	T2350	T2344	arg2Of	ligands,of
R1836	T2350	T2345	arg1Of	ligands,the
R1837	T2350	T2348	arg1Of	ligands,endogenous
R1838	T2350	T2349	arg1Of	ligands,TLR4
R1839	T2350	T2351	arg2Of	ligands,involved
R1840	T2351	T2352	arg1Of	involved,in
R1841	T2354	T2352	arg2Of	pathology,in
R1842	T2354	T2353	arg1Of	pathology,RA
R1843	T2355	T2356	arg1Of	HMGB1,is
R1844	T2355	T2357	arg2Of	HMGB1,increased
R1845	T2357	T2356	arg2Of	increased,is
R1846	T2357	T2358	arg1Of	increased,in
R1847	T2357	T2374	arg1Of	increased,against
R1848	T2361	T2359	arg1Of	tissue,RA
R1849	T2361	T2360	arg1Of	tissue,synovial
R1850	T2361	T2362	arg1Of	tissue,and
R1851	T2362	T2366	arg1Of	and,or
R1852	T2365	T2362	arg2Of	antibodies,and
R1853	T2365	T2363	arg1Of	antibodies,HMGB1
R1854	T2365	T2364	arg1Of	antibodies,neutralising
R1855	T2366	T2358	arg2Of	or,in
R1856	T2370	T2366	arg2Of	domain,or
R1857	T2370	T2367	arg1Of	domain,the
R1858	T2370	T2368	arg1Of	domain,antagonistic
R1859	T2370	T2369	arg1Of	domain,BoxA
R1860	T2370	T2371	arg1Of	domain,of
R1861	T2373	T2371	arg2Of	protect,of
R1862	T2373	T2372	arg1Of	protect,HMGB1
R1863	T2376	T2374	arg2Of	arthritis,against
R1864	T2376	T2375	arg1Of	arthritis,collagen-induced
R1865	T2376	T2377	arg1Of	arthritis,in
R1866	T2378	T2377	arg2Of	mice,in
R1867	T2378	T2379	arg1Of	mice,[
R1868	T2380	T2379	arg2Of	16,[
R1869	T2381	T2379	arg3Of	],[
R1870	T2383	T2382	arg1Of	protein,Myeloid-related
R1871	T2383	T2384	arg1Of	protein,8
R1872	T2383	T2385	arg1Of	protein,and
R1873	T2385	T2389	arg1Of	and,","
R1874	T2385	T2403	arg1Of	and,are
R1875	T2385	T2406	arg1Of	and,present
R1876	T2385	T2413	arg1Of	and,have
R1877	T2385	T2414	arg1Of	and,been
R1878	T2385	T2415	arg2Of	and,suggested
R1879	T2385	T2417	arg1Of	and,be
R1880	T2385	T2418	arg2Of	and,involved
R1881	T2387	T2385	arg2Of	protein,and
R1882	T2387	T2386	arg1Of	protein,myeloid-related
R1883	T2387	T2388	arg1Of	protein,14
R1884	T2393	T2389	arg2Of	molecules,","
R1885	T2393	T2390	arg1Of	molecules,damage-associated
R1886	T2393	T2391	arg1Of	molecules,molecular
R1887	T2393	T2392	arg1Of	molecules,pattern
R1888	T2393	T2394	arg1Of	molecules,belonging
R1889	T2394	T2395	arg1Of	belonging,to
R1890	T2398	T2395	arg2Of	family,to
R1891	T2398	T2396	arg1Of	family,the
R1892	T2398	T2397	arg1Of	family,S100
R1893	T2398	T2399	arg1Of	family,of
R1894	T2401	T2399	arg2Of	proteins,of
R1895	T2401	T2400	arg1Of	proteins,calcium-binding
R1896	T2403	T2404	arg1Of	are,also
R1897	T2403	T2412	arg1Of	are,and
R1898	T2406	T2403	arg2Of	present,are
R1899	T2406	T2405	arg1Of	present,abundantly
R1900	T2406	T2407	arg1Of	present,in
R1901	T2410	T2407	arg2Of	fluid,in
R1902	T2410	T2408	arg1Of	fluid,RA
R1903	T2410	T2409	arg1Of	fluid,synovial
R1904	T2412	T2402	arg1Of	and,","
R1905	T2412	T2411	arg1Of	and,","
R1906	T2415	T2412	arg2Of	suggested,and
R1907	T2415	T2413	arg2Of	suggested,have
R1908	T2415	T2414	arg2Of	suggested,been
R1909	T2418	T2415	arg3Of	involved,suggested
R1910	T2418	T2416	arg1Of	involved,to
R1911	T2418	T2417	arg2Of	involved,be
R1912	T2418	T2419	arg1Of	involved,in
R1913	T2418	T2423	arg1Of	involved,in
R1914	T2422	T2419	arg2Of	inflammation,in
R1915	T2422	T2420	arg1Of	inflammation,TLR4-induced
R1916	T2422	T2421	arg1Of	inflammation,chronic
R1917	T2424	T2423	arg2Of	RA,in
R1918	T2424	T2425	arg1Of	RA,[
R1919	T2426	T2425	arg2Of	"17,18",[
R1920	T2427	T2425	arg3Of	],[
R1921	T2431	T2428	arg1Of	ligands,Other
R1922	T2431	T2429	arg1Of	ligands,endogenous
R1923	T2431	T2430	arg1Of	ligands,TLR
R1924	T2431	T2432	arg1Of	ligands,that
R1925	T2431	T2433	arg1Of	ligands,may
R1926	T2431	T2434	arg1Of	ligands,be
R1927	T2431	T2435	arg2Of	ligands,involved
R1928	T2431	T2439	arg1Of	ligands,are
R1929	T2435	T2433	arg2Of	involved,may
R1930	T2435	T2434	arg2Of	involved,be
R1931	T2435	T2436	arg1Of	involved,in
R1932	T2438	T2436	arg2Of	pathology,in
R1936	T2442	T2444	arg1Of	components,as
R1937	T2442	T2454	arg1Of	components,and
R1938	T2444	T2443	arg1Of	as,such
R1939	T2445	T2446	arg1Of	fibrinogen,","
R1940	T2446	T2448	arg1Of	",",","
R1941	T2447	T2446	arg2Of	fibronectin,","
R1942	T2448	T2450	arg1Of	",",","
R1943	T2449	T2448	arg2Of	biglycan,","
R1944	T2450	T2444	arg2Of	",",as
R1945	T2452	T2450	arg2Of	C,","
R1946	T2452	T2451	arg1Of	C,tenascin
R1947	T2454	T2439	arg2Of	and,are
R1948	T2454	T2453	arg1Of	and,","
R1949	T2457	T2454	arg2Of	fragments,and
R1950	T2457	T2455	arg1Of	fragments,hyal-uronic
R1951	T2457	T2456	arg1Of	fragments,acid
R1952	T2457	T2458	arg1Of	fragments,(
R1953	T2459	T2458	arg2Of	reviewed,(
R1954	T2459	T2460	arg1Of	reviewed,in
R1955	T2459	T2461	arg1Of	reviewed,[
R1956	T2462	T2461	arg2Of	"14,15",[
R1957	T2463	T2461	arg3Of	],[
R1958	T2464	T2458	arg3Of	),(
R1959	T2468	T2467	arg1Of	studies,these
R1960	T2468	T2469	arg1Of	studies,suggest
R1961	T2469	T2465	arg1Of	suggest,Together
R1962	T2469	T2466	arg1Of	suggest,","
R1963	T2473	T2471	arg1Of	ligands,several
R1964	T2473	T2472	arg1Of	ligands,TLR
R1965	T2473	T2474	arg1Of	ligands,in
R1966	T2473	T2479	arg1Of	ligands,may
R1967	T2473	T2480	arg1Of	ligands,contribute
R1968	T2478	T2474	arg2Of	tissue,in
R1969	T2478	T2475	arg1Of	tissue,the
R1970	T2478	T2476	arg1Of	tissue,inflamed
R1971	T2478	T2477	arg1Of	tissue,joint
R1972	T2480	T2469	arg2Of	contribute,suggest
R1973	T2480	T2470	arg1Of	contribute,that
R1974	T2480	T2479	arg2Of	contribute,may
R1975	T2480	T2481	arg1Of	contribute,to
R1976	T2483	T2482	arg1Of	activation,NF-κB
R1977	T2483	T2484	arg1Of	activation,and
R1978	T2484	T2481	arg2Of	and,to
R1979	T2484	T2488	arg1Of	and,in
R1980	T2487	T2484	arg2Of	expression,and
R1981	T2487	T2485	arg1Of	expression,inflammatory
R1982	T2487	T2486	arg1Of	expression,gene
R1983	T2489	T2488	arg2Of	RA,in

UBERON-AE

Id	Subject	Object	Predicate	Lexical cue
T1754	3724-3728	http://purl.obolibrary.org/obo/UBERON_3000101	denotes	hyal
T1753	3456-3470	http://purl.obolibrary.org/obo/UBERON_0001090	denotes	synovial fluid
T1752	3853-3859	http://purl.obolibrary.org/obo/UBERON_0000479	denotes	tissue
T1751	3121-3127	http://purl.obolibrary.org/obo/UBERON_0000479	denotes	tissue
T1750	2550-2557	http://purl.obolibrary.org/obo/UBERON_0000479	denotes	tissues
T1749	2382-2389	http://purl.obolibrary.org/obo/UBERON_0000479	denotes	tissues
T1748	2035-2040	http://purl.obolibrary.org/obo/UBERON_0000062	denotes	organ
T1747	63-70	http://purl.obolibrary.org/obo/UBERON_0012131	denotes	central

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T2513	3912-3927	http://purl.obolibrary.org/obo/GO_0010467	denotes	gene expression
T2512	2800-2812	http://purl.obolibrary.org/obo/GO_0009405	denotes	pathogenesis
T2511	2041-2050	http://purl.obolibrary.org/obo/GO_0009058	denotes	formation
T2510	1761-1776	http://purl.obolibrary.org/obo/GO_0001775	denotes	cell activating
T2509	1759-1776	http://purl.obolibrary.org/obo/GO_0042113	denotes	B-cell activating
T2508	1759-1776	http://purl.obolibrary.org/obo/GO_0050864	denotes	B-cell activating
T2507	1333-1342	http://purl.obolibrary.org/obo/GO_0046903	denotes	secretion
T2506	1304-1328	http://purl.obolibrary.org/obo/GO_0048144	denotes	fibroblast proliferation
T2505	2719-2729	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T2504	1983-1993	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T2503	749-759	http://purl.obolibrary.org/obo/GO_0023052	denotes	signalling
T2502	743-759	http://purl.obolibrary.org/obo/GO_0038061	denotes	NF-κB signalling
T2501	3878-3894	http://purl.obolibrary.org/obo/GO_0051092	denotes	NF-κB activation
T2500	1274-1290	http://purl.obolibrary.org/obo/GO_0051092	denotes	NF-κB activation
T2499	593-609	http://purl.obolibrary.org/obo/GO_0051092	denotes	NF-κB activation
T2498	481-497	http://purl.obolibrary.org/obo/GO_0051092	denotes	NF-κB activation
T2497	433-452	http://purl.obolibrary.org/obo/GO_0051092	denotes	activators of NF-κB
T2496	184-198	http://purl.obolibrary.org/obo/GO_0051092	denotes	activate NF-κB
T2495	3535-3547	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammation
T2494	2761-2773	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammation
T2493	2480-2492	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammation
T2492	2245-2257	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammation
T2491	2071-2083	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammation
T2490	89-101	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammation

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T2530	3404-3420	http://purl.obolibrary.org/obo/GO_0005515	denotes	binding proteins
T2529	3396-3420	http://purl.obolibrary.org/obo/GO_0048306	denotes	calcium-binding proteins
T2528	3151-3161	http://purl.obolibrary.org/obo/GO_0003823	denotes	antibodies
T2527	1665-1675	http://purl.obolibrary.org/obo/GO_0003823	denotes	antibodies
T2526	1487-1497	http://purl.obolibrary.org/obo/GO_0003823	denotes	antibodies
T2525	3823-3830	http://purl.obolibrary.org/obo/GO_0005488	denotes	ligands
T2524	3584-3591	http://purl.obolibrary.org/obo/GO_0005488	denotes	ligands
T2523	3053-3060	http://purl.obolibrary.org/obo/GO_0005488	denotes	ligands
T2522	2581-2588	http://purl.obolibrary.org/obo/GO_0005488	denotes	ligands
T2521	2334-2341	http://purl.obolibrary.org/obo/GO_0005488	denotes	ligands
T2520	2290-2297	http://purl.obolibrary.org/obo/GO_0005488	denotes	ligands
T2519	1176-1182	http://purl.obolibrary.org/obo/GO_0005488	denotes	ligand
T2518	1156-1163	http://purl.obolibrary.org/obo/GO_0005488	denotes	Binding
T2517	407-411	http://purl.obolibrary.org/obo/GO_0005149	denotes	IL-1
T2516	273-277	http://purl.obolibrary.org/obo/GO_0005149	denotes	IL-1

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T2543	2903-2912	http://purl.obolibrary.org/obo/GO_0000785	denotes	chromatin
T2542	2853-2864	http://purl.obolibrary.org/obo/GO_0005694	denotes	chromosomal
T2541	2377-2381	http://purl.obolibrary.org/obo/GO_0018995	denotes	host
T2540	3151-3161	http://purl.obolibrary.org/obo/GO_0042571	denotes	antibodies
T2539	1665-1675	http://purl.obolibrary.org/obo/GO_0042571	denotes	antibodies
T2538	1487-1497	http://purl.obolibrary.org/obo/GO_0042571	denotes	antibodies
T2537	3151-3161	http://purl.obolibrary.org/obo/GO_0019815	denotes	antibodies
T2536	1665-1675	http://purl.obolibrary.org/obo/GO_0019815	denotes	antibodies
T2535	1487-1497	http://purl.obolibrary.org/obo/GO_0019815	denotes	antibodies
T2534	3002-3007	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2533	2394-2399	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2532	1761-1765	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T2531	942-946	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T2547	3673-3683	http://purl.obolibrary.org/obo/GO_0005577	denotes	fibrinogen
T2546	3633-3664	http://purl.obolibrary.org/obo/GO_0044420	denotes	extracellular matrix components
T2545	3633-3653	http://purl.obolibrary.org/obo/GO_0031012	denotes	extracellular matrix
T2544	3633-3646	http://purl.obolibrary.org/obo/GO_0005576	denotes	extracellular

sentences

Id	Subject	Object	Predicate	Lexical cue
T1758	593-851	Sentence	denotes	NF-κB activation by receptor activator of NF-κB (RANK), a TNF receptor family member, is important for osteoclastogenesis, and defects in proper RANK-NF-κB signalling are likely to be involved in RA pathology and other diseases associated with bone loss [7].
T1757	399-592	Sentence	denotes	TNF and IL-1 are both very potent activators of NF-κB and it can be expected that NF-κB activation by these cytokines mediates most of their pro-inflammatory activities in RA (reviewed in [3]).
T1756	206-398	Sentence	denotes	It is well accepted that proinflammatory cytokines such as TNF and IL-1 play an important role, and administration of TNF antagonists is an effective treatment for severe RA (reviewed in [9]).
T1755	48-205	Sentence	denotes	Since NF-κB is central to the process of inflammation in RA, much research deals with the identification of the molecular triggers that activate NF-κB in RA.
T1772	3774-3934	Sentence	denotes	Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA.
T1771	3563-3773	Sentence	denotes	Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]).
T1770	3260-3562	Sentence	denotes	Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18].
T1769	3087-3259	Sentence	denotes	HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16].
T1768	2829-3086	Sentence	denotes	High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology.
T1767	2644-2828	Sentence	denotes	Moreover, animal models using TLR knockout mice or strategies to block TLR signalling clearly identify TLR-dependent inflammation as being important in the pathogenesis of the disease.
T1766	2516-2643	Sentence	denotes	TLRs are expressed in RA synovial tissues and various endogenous ligands are present within the inflamed joints of RA patients.
T1765	2265-2515	Sentence	denotes	In addition to microbial ligands, an increasing number of endogenous ligands - a group of proteins derived from host tissues and cells - have been reported as candidate activators of TLRs inducing so-called sterile inflammation (reviewed in [14,15]).
T1764	2103-2264	Sentence	denotes	Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases and are potential candidates for inducing NF-κB-dependent inflammation in RA.
T1763	1951-2102	Sentence	denotes	Finally, lymphotoxin β receptor signalling has been implicated in tertiary lymphoid organ formation at sites of chronic inflammation including RA [13].
T1762	1705-1950	Sentence	denotes	Enhanced expression of the TNF receptor family member B-cell activating factor (BAFF), allowing the survival of autoantibody- producing B lymphocytes, is also characteristic for RA, and antagonists of BAFF have been developed to counter RA [13].
T1761	1428-1704	Sentence	denotes	However, studies with antagonistic anti-CD40 or anti-CD154 antibodies led to the conclusion that CD40 signals may be important at the initial stages of arthritis induction, but are not required once disease is established and pathogenic antibodies are already present [11,12].
T1760	1156-1427	Sentence	denotes	Binding of the CD40 ligand (CD154), which is transiently expressed on the surface of activated CD4+ T cells, triggers NF-κB activation resulting in fibroblast proliferation and secretion of proinflammatory cytokines and chemokines, which contributes to joint destruction.
T1759	852-1155	Sentence	denotes	CD40 is another TNF receptor family member that is functionally expressed on a variety of cell types, including smooth muscle fibroblasts from normal and RA patients and RA synovial cells, B cells, macrophages, and dendritic cells, and can be upregulated by proinflammatory cytokines including TNF [10].
T19	0-47	Sentence	denotes	Pathological triggers of NF-κB signalling in RA
T20	48-205	Sentence	denotes	Since NF-κB is central to the process of inflammation in RA, much research deals with the identification of the molecular triggers that activate NF-κB in RA.
T21	206-398	Sentence	denotes	It is well accepted that proinflammatory cytokines such as TNF and IL-1 play an important role, and administration of TNF antagonists is an effective treatment for severe RA (reviewed in [9]).
T22	399-592	Sentence	denotes	TNF and IL-1 are both very potent activators of NF-κB and it can be expected that NF-κB activation by these cytokines mediates most of their pro-inflammatory activities in RA (reviewed in [3]).
T23	593-851	Sentence	denotes	NF-κB activation by receptor activator of NF-κB (RANK), a TNF receptor family member, is important for osteoclastogenesis, and defects in proper RANK-NF-κB signalling are likely to be involved in RA pathology and other diseases associated with bone loss [7].
T24	852-1155	Sentence	denotes	CD40 is another TNF receptor family member that is functionally expressed on a variety of cell types, including smooth muscle fibroblasts from normal and RA patients and RA synovial cells, B cells, macrophages, and dendritic cells, and can be upregulated by proinflammatory cytokines including TNF [10].
T25	1156-1427	Sentence	denotes	Binding of the CD40 ligand (CD154), which is transiently expressed on the surface of activated CD4+ T cells, triggers NF-κB activation resulting in fibroblast proliferation and secretion of proinflammatory cytokines and chemokines, which contributes to joint destruction.
T26	1428-1704	Sentence	denotes	However, studies with antagonistic anti-CD40 or anti-CD154 antibodies led to the conclusion that CD40 signals may be important at the initial stages of arthritis induction, but are not required once disease is established and pathogenic antibodies are already present [11,12].
T27	1705-1950	Sentence	denotes	Enhanced expression of the TNF receptor family member B-cell activating factor (BAFF), allowing the survival of autoantibody- producing B lymphocytes, is also characteristic for RA, and antagonists of BAFF have been developed to counter RA [13].
T28	1951-2102	Sentence	denotes	Finally, lymphotoxin β receptor signalling has been implicated in tertiary lymphoid organ formation at sites of chronic inflammation including RA [13].
T29	2103-2264	Sentence	denotes	Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases and are potential candidates for inducing NF-κB-dependent inflammation in RA.
T30	2265-2515	Sentence	denotes	In addition to microbial ligands, an increasing number of endogenous ligands - a group of proteins derived from host tissues and cells - have been reported as candidate activators of TLRs inducing so-called sterile inflammation (reviewed in [14,15]).
T31	2516-2643	Sentence	denotes	TLRs are expressed in RA synovial tissues and various endogenous ligands are present within the inflamed joints of RA patients.
T32	2644-2828	Sentence	denotes	Moreover, animal models using TLR knockout mice or strategies to block TLR signalling clearly identify TLR-dependent inflammation as being important in the pathogenesis of the disease.
T33	2829-3086	Sentence	denotes	High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology.
T34	3087-3259	Sentence	denotes	HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16].
T35	3260-3562	Sentence	denotes	Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18].
T36	3563-3773	Sentence	denotes	Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]).
T37	3774-3934	Sentence	denotes	Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA.

ICD10

Id	Subject	Object	Predicate	Lexical cue
T2515	3236-3245	http://purl.bioontology.org/ontology/ICD10/M13.9	denotes	arthritis
T2514	1580-1589	http://purl.bioontology.org/ontology/ICD10/M13.9	denotes	arthritis

simple1

Id	Subject	Object	Predicate	Lexical cue
T2603	3708-3718	Protein	denotes	tenascin C
T2602	3698-3706	Protein	denotes	biglycan
T2601	3685-3696	Protein	denotes	fibronectin
T2600	3514-3518	Protein	denotes	TLR4
T2599	3290-3316	Protein	denotes	myeloid-related protein 14
T2598	3260-3285	Protein	denotes	Myeloid-related protein 8
T2597	3197-3202	Protein	denotes	HMGB1
T2596	3132-3137	Protein	denotes	HMGB1
T2595	3087-3092	Protein	denotes	HMGB1
T2594	3048-3060	Protein	denotes	TLR4 ligands
T2593	2903-2922	Protein	denotes	chromatin component
T2592	2876-2881	Protein	denotes	HMGB1
T2591	2829-2874	Protein	denotes	High mobility group box chromosomal protein 1
T2590	1960-1982	Protein	denotes	lymphotoxin β receptor
T2589	1906-1910	Protein	denotes	BAFF
T2588	1785-1789	Protein	denotes	BAFF
T2587	1759-1783	Protein	denotes	B-cell activating factor
T2586	1525-1529	Protein	denotes	CD40
T2585	1251-1254	Protein	denotes	CD4
T2584	1184-1189	Protein	denotes	CD154
T2583	1171-1182	Protein	denotes	CD40 ligand
T2582	1146-1149	Protein	denotes	TNF
T2581	868-894	Protein	denotes	TNF receptor family member
T2580	852-856	Protein	denotes	CD40
T2579	738-742	Protein	denotes	RANK
T2578	642-646	Protein	denotes	RANK
T2577	613-640	Protein	denotes	receptor activator of NF-κB
T2576	399-402	Protein	denotes	TNF
T2575	324-327	Protein	denotes	TNF
T2574	265-268	Protein	denotes	TNF

BioNLP16_DUT

Id	Subject	Object	Predicate	Lexical cue
T3583	3519-3526	Positive_regulation	denotes	induced
T3582	3096-3105	Positive_regulation	denotes	increased
T3581	2981-2989	Localization	denotes	released
T3580	2944-2952	Localization	denotes	secreted
T3579	1714-1724	Gene_expression	denotes	expression
T3578	1705-1713	Positive_regulation	denotes	Enhanced
T3577	1156-1163	Binding	denotes	Binding
T3576	1213-1222	Gene_expression	denotes	expressed
T3575	916-925	Gene_expression	denotes	expressed
T3574	1095-1106	Positive_regulation	denotes	upregulated
T3573	3708-3718	Protein	denotes	tenascin C
T3572	3698-3706	Protein	denotes	biglycan
T3571	3685-3696	Protein	denotes	fibronectin
T3570	3514-3518	Protein	denotes	TLR4
T3569	3290-3316	Protein	denotes	myeloid-related protein 14
T3568	3260-3285	Protein	denotes	Myeloid-related protein 8
T3567	3197-3202	Protein	denotes	HMGB1
T3566	3132-3137	Protein	denotes	HMGB1
T3565	3087-3092	Protein	denotes	HMGB1
T3564	3048-3060	Protein	denotes	TLR4 ligands
T3563	2903-2922	Protein	denotes	chromatin component
T3562	2876-2881	Protein	denotes	HMGB1
T3561	2829-2874	Protein	denotes	High mobility group box chromosomal protein 1
T3560	1960-1982	Protein	denotes	lymphotoxin β receptor
T3559	1906-1910	Protein	denotes	BAFF
T3558	1785-1789	Protein	denotes	BAFF
T3557	1759-1783	Protein	denotes	B-cell activating factor
T3556	1525-1529	Protein	denotes	CD40
T3555	1251-1254	Protein	denotes	CD4
T3554	1184-1189	Protein	denotes	CD154
T3553	1171-1182	Protein	denotes	CD40 ligand
T3552	1146-1149	Protein	denotes	TNF
T3551	868-894	Protein	denotes	TNF receptor family member
T3550	852-856	Protein	denotes	CD40
T3549	738-742	Protein	denotes	RANK
T3548	642-646	Protein	denotes	RANK
T3547	613-640	Protein	denotes	receptor activator of NF-κB
T3546	399-402	Protein	denotes	TNF
T3545	324-327	Protein	denotes	TNF
T3544	265-268	Protein	denotes	TNF
R2748	T3550	T3574	themeOf	CD40,upregulated
R2749	T3550	T3575	themeOf	CD40,expressed
R2751	T3551	T3574	themeOf	TNF receptor family member,upregulated
R2752	T3551	T3575	themeOf	TNF receptor family member,expressed
R2753	T3552	T3574	causeOf	TNF,upregulated
R2754	T3552	T3574	causeOf	TNF,upregulated
R2755	T3553	T3576	themeOf	CD40 ligand,expressed
R2756	T3553	T3577	themeOf	CD40 ligand,Binding
R2757	T3554	T3576	themeOf	CD154,expressed
R2758	T3554	T3577	themeOf	CD154,Binding
R2759	T3557	T3579	themeOf	B-cell activating factor,expression
R2760	T3558	T3579	themeOf	BAFF,expression
R2761	T3561	T3580	themeOf	High mobility group box chromosomal protein 1,secreted
R2762	T3561	T3581	themeOf	High mobility group box chromosomal protein 1,released
R2763	T3562	T3581	themeOf	HMGB1,released
R2764	T3563	T3580	themeOf	chromatin component,secreted
R2765	T3563	T3581	themeOf	chromatin component,released
R2766	T3564	T3581	themeOf	TLR4 ligands,released
R2767	T3565	T3582	themeOf	HMGB1,increased
R2769	T3570	T3583	themeOf	TLR4,induced
R2770	T3579	T3578	themeOf	expression,Enhanced
R2771	T3579	T3578	themeOf	expression,Enhanced

BioNLP16_Messiy

Id	Subject	Object	Predicate	Lexical cue
T3327	3519-3526	Positive_regulation	denotes	induced
T3326	3096-3105	Positive_regulation	denotes	increased
T3325	2981-2989	Localization	denotes	released
T3324	2944-2952	Localization	denotes	secreted
T3323	1705-1713	Positive_regulation	denotes	Enhanced
T3322	1714-1724	Gene_expression	denotes	expression
T3321	1213-1222	Gene_expression	denotes	expressed
T3320	1156-1163	Binding	denotes	Binding
T3319	916-925	Gene_expression	denotes	expressed
T3318	1095-1106	Positive_regulation	denotes	upregulated
T3317	3708-3718	Protein	denotes	tenascin C
T3316	3698-3706	Protein	denotes	biglycan
T3304	1960-1982	Protein	denotes	lymphotoxin β receptor
T3303	1906-1910	Protein	denotes	BAFF
T3302	1785-1789	Protein	denotes	BAFF
T3301	1759-1783	Protein	denotes	B-cell activating factor
T3300	1525-1529	Protein	denotes	CD40
T3299	1251-1254	Protein	denotes	CD4
T3298	1184-1189	Protein	denotes	CD154
T3297	1171-1182	Protein	denotes	CD40 ligand
T3296	1146-1149	Protein	denotes	TNF
T3295	868-894	Protein	denotes	TNF receptor family member
T3294	852-856	Protein	denotes	CD40
T3293	738-742	Protein	denotes	RANK
T3292	642-646	Protein	denotes	RANK
T3291	613-640	Protein	denotes	receptor activator of NF-κB
T3290	399-402	Protein	denotes	TNF
T3289	324-327	Protein	denotes	TNF
T3288	265-268	Protein	denotes	TNF
T3315	3685-3696	Protein	denotes	fibronectin
T3314	3514-3518	Protein	denotes	TLR4
T3313	3290-3316	Protein	denotes	myeloid-related protein 14
T3312	3260-3285	Protein	denotes	Myeloid-related protein 8
T3311	3197-3202	Protein	denotes	HMGB1
T3310	3132-3137	Protein	denotes	HMGB1
T3309	3087-3092	Protein	denotes	HMGB1
T3308	3048-3060	Protein	denotes	TLR4 ligands
T3307	2903-2922	Protein	denotes	chromatin component
T3306	2876-2881	Protein	denotes	HMGB1
T3305	2829-2874	Protein	denotes	High mobility group box chromosomal protein 1
R2612	T3294	T3319	themeOf	CD40,expressed
R2613	T3295	T3318	themeOf	TNF receptor family member,upregulated
R2614	T3295	T3319	themeOf	TNF receptor family member,expressed
R2616	T3297	T3321	themeOf	CD40 ligand,expressed
R2617	T3297	T3320	themeOf	CD40 ligand,Binding
R2618	T3298	T3321	themeOf	CD154,expressed
R2619	T3298	T3320	themeOf	CD154,Binding
R2621	T3301	T3322	themeOf	B-cell activating factor,expression
R2623	T3302	T3322	themeOf	BAFF,expression
R2627	T3305	T3325	themeOf	High mobility group box chromosomal protein 1,released
R2628	T3307	T3324	themeOf	chromatin component,secreted
R2629	T3307	T3325	themeOf	chromatin component,released
R2630	T3309	T3326	themeOf	HMGB1,increased
R2633	T3314	T3327	themeOf	TLR4,induced
R2637	T3322	T3323	themeOf	expression,Enhanced
R2638	T3322	T3323	themeOf	expression,Enhanced

bionlp-st-ge-2016-test-ihmc

Id	Subject	Object	Predicate	Lexical cue
T3698	3878-3894	Positive_regulation	denotes	NF-κB activation
T3697	1156-1191	Binding	denotes	Binding of the CD40 ligand (CD154),
T3696	2355-2381	Gene_expression	denotes	proteins derived from host
T3695	1274-1300	Positive_regulation	denotes	NF-κB activation resulting
T3694	343-379	Regulation	denotes	an effective treatment for severe RA
T3693	593-678	Positive_regulation	denotes	NF-κB activation by receptor activator of NF-κB (RANK), a TNF receptor family member,
T3692	2103-2186	Gene_expression	denotes	Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases
T3691	2562-2588	Entity	denotes	various endogenous ligands
T3690	1164-1191	Entity	denotes	of the CD40 ligand (CD154),
T3689	651-654	Protein	denotes	TNF
T3688	2538-2540	Protein	denotes	RA
T3665	3290-3316	Protein	denotes	myeloid-related protein 14
T3664	1067-1082	Entity	denotes	dendritic cells
T3663	2953-2967	Entity	denotes	by macrophages
T3662	3048-3052	Protein	denotes	TLR4
T3661	231-268	Protein	denotes	proinflammatory cytokines such as TNF
T3660	3685-3696	Protein	denotes	fibronectin
T3659	501-516	Protein	denotes	these cytokines
T3658	447-452	Protein	denotes	NF-κB
T3657	1050-1083	Entity	denotes	macrophages, and dendritic cells,
T3656	872-880	Protein	denotes	receptor
T3655	1025-1039	Entity	denotes	synovial cells
T3654	3724-3740	Entity	denotes	hyal-uronic acid
T3653	3931-3933	Protein	denotes	RA
T3652	2687-2691	Protein	denotes	mice
T3651	1906-1910	Protein	denotes	BAFF
T3650	3132-3161	Entity	denotes	HMGB1 neutralising antibodies
T3649	3260-3285	Protein	denotes	Myeloid-related protein 8
T3648	2424-2444	Entity	denotes	candidate activators
T3647	2631-2633	Protein	denotes	RA
T3646	2355-2381	Protein	denotes	proteins derived from host
T3645	3878-3883	Protein	denotes	NF-κB
T3644	105-107	Protein	denotes	RA
T3643	3109-3111	Protein	denotes	RA
T3642	1376-1387	Protein	denotes	chemokines,
T3641	1785-1789	Protein	denotes	BAFF
T3640	3453-3455	Protein	denotes	RA
T3639	1006-1008	Protein	denotes	RA
T3638	2903-2912	Entity	denotes	chromatin
T3637	3673-3683	Protein	denotes	fibrinogen
T3636	399-402	Protein	denotes	TNF
T3635	655-663	Protein	denotes	receptor
T3634	3698-3706	Protein	denotes	biglycan
T3633	1654-1675	Entity	denotes	pathogenic antibodies
T3632	1450-1472	Protein	denotes	antagonistic anti-CD40
T3631	1022-1024	Protein	denotes	RA
T3630	407-411	Protein	denotes	IL-1
T3629	2280-2298	Entity	denotes	microbial ligands,
T3628	635-647	Protein	denotes	NF-κB (RANK)
T3627	3185-3202	Entity	denotes	A domain of HMGB1
T3626	3249-3258	Protein	denotes	mice [16]
T3625	3070-3085	Protein	denotes	in RA pathology
T3624	3396-3420	Protein	denotes	calcium-binding proteins
T3623	193-198	Protein	denotes	NF-κB
T3622	2261-2263	Protein	denotes	RA
T3621	964-989	Entity	denotes	smooth muscle fibroblasts
T3620	3633-3672	Entity	denotes	extracellular matrix components such as
T3619	2448-2492	Protein	denotes	TLRs inducing so-called sterile inflammation
T3618	1814-1829	Protein	denotes	of autoantibody
T3617	3012-3085	Entity	denotes	one of the most putative endogenous TLR4 ligands involved in RA pathology
T3616	324-339	Entity	denotes	TNF antagonists
T3615	868-871	Protein	denotes	TNF
T3614	3377-3421	Protein	denotes	the S100 family of calcium-binding proteins,
T3613	3132-3161	Protein	denotes	HMGB1 neutralising antibodies
T3612	3219-3235	Entity	denotes	collagen-induced
T3611	231-264	Protein	denotes	proinflammatory cytokines such as
T3610	1725-1765	Entity	denotes	of the TNF receptor family member B-cell
T3609	1520-1529	Protein	denotes	that CD40
T3608	3584-3618	Entity	denotes	ligands that may be involved in RA
T3607	1476-1497	Entity	denotes	anti-CD154 antibodies
T3606	1184-1189	Protein	denotes	CD154
T3605	571-573	Protein	denotes	RA
T3604	642-646	Protein	denotes	RANK
T3603	939-953	Entity	denotes	of cell types,
T3602	366-379	Protein	denotes	for severe RA
T3601	3016-3085	Entity	denotes	of the most putative endogenous TLR4 ligands involved in RA pathology
T3600	54-59	Protein	denotes	NF-κB
T3599	3087-3092	Protein	denotes	HMGB1
T3598	2103-2129	Protein	denotes	Toll-like receptors (TLRs)
T3597	2876-2881	Protein	denotes	HMGB1
T3596	1126-1154	Protein	denotes	cytokines including TNF [10]
T3595	1146-1154	Protein	denotes	TNF [10]
T3594	2229-2244	Protein	denotes	NF-κB-dependent
T3593	2320-2381	Entity	denotes	of endogenous ligands - a group of proteins derived from host
T3592	3197-3202	Protein	denotes	HMGB1
T3591	852-856	Protein	denotes	CD40
T3590	731-759	Protein	denotes	proper RANK-NF-κB signalling
T3589	2094-2101	Protein	denotes	RA [13]
T3588	3708-3716	Protein	denotes	tenascin
T3587	3811-3859	Entity	denotes	several TLR ligands in the inflamed joint tissue
T3586	2829-2883	Protein	denotes	High mobility group box chromosomal protein 1 (HMGB1),
T3585	3354-3363	Entity	denotes	molecules
T3584	610-631	Protein	denotes	by receptor activator
T3687	3514-3526	Protein	denotes	TLR4-induced
T3686	324-327	Protein	denotes	TNF
T3685	1171-1175	Protein	denotes	CD40
T3684	1960-1993	Protein	denotes	lymphotoxin β receptor signalling
T3683	1891-1910	Entity	denotes	antagonists of BAFF
T3682	789-801	Protein	denotes	RA pathology
T3681	202-204	Protein	denotes	RA
T3680	1476-1497	Protein	denotes	anti-CD154 antibodies
T3679	3613-3618	Protein	denotes	in RA
T3678	731-759	Protein	denotes	proper RANK-NF-κB signalling
T3677	3551-3553	Protein	denotes	RA
T3676	1238-1263	Entity	denotes	of activated CD4+ T cells
T3675	416-452	Entity	denotes	both very potent activators of NF-κB
T3674	1041-1048	Entity	denotes	B cells
T3673	1274-1279	Protein	denotes	NF-κB
T3672	1732-1758	Protein	denotes	TNF receptor family member
T3671	1362-1371	Protein	denotes	cytokines
T3670	1883-1886	Entity	denotes	RA,
T3669	273-277	Protein	denotes	IL-1
T3668	481-516	Protein	denotes	NF-κB activation by these cytokines
T3667	593-598	Protein	denotes	NF-κB
T3666	1841-1854	Entity	denotes	B lymphocytes
R2747	T3584	T3693	causeOf	by receptor activator,"NF-κB activation by receptor activator of NF-κB (RANK), a TNF receptor family member,"
R2750	T3598	T3692	themeOf	Toll-like receptors (TLRs),Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases
R2768	T3602	T3694	themeOf	for severe RA,an effective treatment for severe RA
R2772	T3645	T3698	themeOf	NF-κB,NF-κB activation
R2773	T3646	T3696	themeOf	proteins derived from host,proteins derived from host
R2774	T3667	T3693	themeOf	NF-κB,"NF-κB activation by receptor activator of NF-κB (RANK), a TNF receptor family member,"
R2775	T3673	T3695	themeOf	NF-κB,NF-κB activation resulting

bionlp-st-ge-2016-test-tees

Id	Subject	Object	Predicate	Lexical cue
T3444	1714-1724	Gene_expression	denotes	expression
T3443	1785-1789	Protein	denotes	BAFF
T3442	1732-1783	Protein	denotes	TNF receptor family member B-cell activating factor
T3441	1525-1537	Protein	denotes	CD40 signals
T3440	1476-1497	Protein	denotes	anti-CD154 antibodies
T3439	1468-1472	Protein	denotes	CD40
T3438	1280-1290	Positive_regulation	denotes	activation
T3437	1280-1290	Positive_regulation	denotes	activation
T3436	1213-1222	Gene_expression	denotes	expressed
T3435	1213-1222	Gene_expression	denotes	expressed
T3359	1156-1163	Binding	denotes	Binding
T3358	1277-1279	Protein	denotes	κB
T3357	1274-1276	Protein	denotes	NF
T3356	1251-1255	Protein	denotes	CD4+
T3355	1184-1189	Protein	denotes	CD154
T3354	1171-1182	Protein	denotes	CD40 ligand
T3353	1095-1106	Positive_regulation	denotes	upregulated
T3352	1095-1106	Positive_regulation	denotes	upregulated
T3351	1095-1106	Positive_regulation	denotes	upregulated
T3350	916-925	Gene_expression	denotes	expressed
T3349	916-925	Gene_expression	denotes	expressed
T3348	868-894	Protein	denotes	TNF receptor family member
T3347	852-856	Protein	denotes	CD40
T3343	651-677	Protein	denotes	TNF receptor family member
T3342	642-646	Protein	denotes	RANK
T3341	635-640	Protein	denotes	NF-κB
T3340	593-598	Protein	denotes	NF-κB
T3339	517-525	Positive_regulation	denotes	mediates
T3338	487-497	Positive_regulation	denotes	activation
T3337	481-486	Protein	denotes	NF-κB
T3336	447-452	Protein	denotes	NF-κB
T3335	407-411	Protein	denotes	IL-1
T3334	399-402	Protein	denotes	TNF
T3333	324-327	Protein	denotes	TNF
T3332	273-277	Protein	denotes	IL-1
T3331	265-268	Protein	denotes	TNF
T3330	184-192	Positive_regulation	denotes	activate
T3329	193-198	Protein	denotes	NF-κB
T3328	54-59	Protein	denotes	NF-κB
T3346	599-609	Positive_regulation	denotes	activation
T3345	599-609	Positive_regulation	denotes	activation
T3344	738-748	Protein	denotes	RANK-NF-κB
T3434	1156-1163	Binding	denotes	Binding
T3472	3864-3874	Positive_regulation	denotes	contribute
T3471	3884-3894	Positive_regulation	denotes	activation
T3470	3878-3883	Protein	denotes	NF-κB
T3469	3708-3718	Protein	denotes	tenascin C
T3468	3685-3696	Protein	denotes	fibronectin
T3467	3673-3683	Protein	denotes	fibrinogen
T3466	3514-3518	Protein	denotes	TLR4
T3465	3381-3392	Protein	denotes	S100 family
T3464	3096-3105	Positive_regulation	denotes	increased
T3463	3219-3227	Protein	denotes	collagen
T3462	3197-3202	Protein	denotes	HMGB1
T3461	3182-3193	Protein	denotes	BoxA domain
T3460	3132-3161	Protein	denotes	HMGB1 neutralising antibodies
T3459	3087-3092	Protein	denotes	HMGB1
T3458	2981-2989	Localization	denotes	released
T3457	2981-2989	Localization	denotes	released
T3456	2944-2952	Localization	denotes	secreted
T3455	2944-2952	Localization	denotes	secreted
T3454	3048-3052	Protein	denotes	TLR4
T3453	2876-2881	Protein	denotes	HMGB1
T3452	2829-2874	Protein	denotes	High mobility group box chromosomal protein 1
T3451	2709-2714	Negative_regulation	denotes	block
T3450	2715-2718	Protein	denotes	TLR
T3449	2229-2234	Protein	denotes	NF-κB
T3448	1960-1982	Protein	denotes	lymphotoxin β receptor
T3447	1705-1713	Positive_regulation	denotes	Enhanced
T3446	1705-1713	Positive_regulation	denotes	Enhanced
T3445	1714-1724	Gene_expression	denotes	expression
R2648	T3329	T3330	themeOf	NF-κB,activate
R2652	T3337	T3338	themeOf	NF-κB,activation
R2654	T3338	T3339	themeOf	activation,mediates
R2656	T3340	T3345	themeOf	NF-κB,activation
R2658	T3343	T3346	themeOf	TNF receptor family member,activation
R2662	T3347	T3349	themeOf	CD40,expressed
R2663	T3347	T3351	themeOf	CD40,upregulated
R2664	T3348	T3350	themeOf	TNF receptor family member,expressed
R2666	T3349	T3352	themeOf	expressed,upregulated
R2667	T3350	T3353	themeOf	expressed,upregulated
R2670	T3354	T3359	themeOf	CD40 ligand,Binding
R2671	T3354	T3435	themeOf	CD40 ligand,expressed
R2672	T3355	T3434	themeOf	CD154,Binding
R2673	T3355	T3436	themeOf	CD154,expressed
R2675	T3357	T3437	themeOf	NF,activation
R2676	T3358	T3438	themeOf	κB,activation
R2707	T3445	T3447	themeOf	expression,Enhanced
R2708	T3450	T3451	themeOf	TLR,block
R2709	T3442	T3444	themeOf	TNF receptor family member B-cell activating factor,expression
R2710	T3443	T3445	themeOf	BAFF,expression
R2711	T3444	T3446	themeOf	expression,Enhanced
R2712	T3452	T3455	themeOf	High mobility group box chromosomal protein 1,secreted
R2713	T3452	T3457	themeOf	High mobility group box chromosomal protein 1,released
R2714	T3453	T3456	themeOf	HMGB1,secreted
R2715	T3453	T3458	themeOf	HMGB1,released
R2716	T3459	T3464	themeOf	HMGB1,increased
R2718	T3470	T3471	themeOf	NF-κB,activation
R2726	T3471	T3472	themeOf	activation,contribute

test3

Id	Subject	Object	Predicate	Lexical cue
T1746	3708-3718	Protein	denotes	tenascin C
T1745	3698-3706	Protein	denotes	biglycan
T1744	3685-3696	Protein	denotes	fibronectin
T1743	3514-3518	Protein	denotes	TLR4
T1742	3290-3316	Protein	denotes	myeloid-related protein 14
T1741	3260-3285	Protein	denotes	Myeloid-related protein 8
T1740	3197-3202	Protein	denotes	HMGB1
T1739	3132-3137	Protein	denotes	HMGB1
T1738	3087-3092	Protein	denotes	HMGB1
T1737	3048-3060	Protein	denotes	TLR4 ligands
T1736	2981-2989	Localization	denotes	released
T1735	2903-2922	Protein	denotes	chromatin component
T1734	2876-2881	Protein	denotes	HMGB1
T1733	2829-2874	Protein	denotes	High mobility group box chromosomal protein 1
T1732	1960-1982	Protein	denotes	lymphotoxin β receptor
T1731	1906-1910	Protein	denotes	BAFF
T1730	1831-1840	Gene_expression	denotes	producing
T1729	1785-1789	Protein	denotes	BAFF
T1728	1759-1783	Protein	denotes	B-cell activating factor
T1727	1714-1724	Gene_expression	denotes	expression
T1726	1705-1713	Positive_regulation	denotes	Enhanced
T1725	1525-1529	Protein	denotes	CD40
T1724	1251-1254	Protein	denotes	CD4
T1723	1213-1222	Gene_expression	denotes	expressed
T1722	1184-1189	Protein	denotes	CD154
T1721	1171-1182	Protein	denotes	CD40 ligand
T1720	1156-1163	Binding	denotes	Binding
T1719	1146-1149	Protein	denotes	TNF
T1718	916-925	Gene_expression	denotes	expressed
T1717	868-894	Protein	denotes	TNF receptor family member
T1716	852-856	Protein	denotes	CD40
T1715	738-742	Protein	denotes	RANK
T1714	642-646	Protein	denotes	RANK
T1713	613-640	Protein	denotes	receptor activator of NF-κB
T1712	399-402	Protein	denotes	TNF
T1711	324-327	Protein	denotes	TNF
T1710	265-268	Protein	denotes	TNF
T1709	3708-3718	Protein	denotes	tenascin C
T1708	3698-3706	Protein	denotes	biglycan
T1707	3685-3696	Protein	denotes	fibronectin
T1706	3514-3518	Protein	denotes	TLR4
T1705	3290-3316	Protein	denotes	myeloid-related protein 14
T1704	3260-3285	Protein	denotes	Myeloid-related protein 8
T1703	3197-3202	Protein	denotes	HMGB1
T1702	3132-3137	Protein	denotes	HMGB1
T1701	3087-3092	Protein	denotes	HMGB1
T1700	3048-3060	Protein	denotes	TLR4 ligands
T1699	2903-2922	Protein	denotes	chromatin component
T1698	2876-2881	Protein	denotes	HMGB1
T1697	2829-2874	Protein	denotes	High mobility group box chromosomal protein 1
T1696	1960-1982	Protein	denotes	lymphotoxin β receptor
T1695	1906-1910	Protein	denotes	BAFF
T1694	1785-1789	Protein	denotes	BAFF
T1693	1759-1783	Protein	denotes	B-cell activating factor
T1692	1525-1529	Protein	denotes	CD40
T1691	1251-1254	Protein	denotes	CD4
T1690	1184-1189	Protein	denotes	CD154
T1689	1171-1182	Protein	denotes	CD40 ligand
T1688	1146-1149	Protein	denotes	TNF
T1687	868-894	Protein	denotes	TNF receptor family member
T1686	852-856	Protein	denotes	CD40
T1685	738-742	Protein	denotes	RANK
T1684	642-646	Protein	denotes	RANK
T1683	613-640	Protein	denotes	receptor activator of NF-κB
T1682	399-402	Protein	denotes	TNF
T1681	324-327	Protein	denotes	TNF
T1680	265-268	Protein	denotes	TNF
R1282	T1714	T1713	equivalentTo	RANK,receptor activator of NF-κB
R1283	T1715	T1714	themeOf	RANK,RANK
R1284	T1716	T1718	themeOf	CD40,expressed
R1285	T1717	T1718	themeOf	TNF receptor family member,expressed
R1286	T1721	T1723	themeOf	CD40 ligand,expressed
R1287	T1721	T1720	themeOf	CD40 ligand,Binding
R1288	T1722	T1721	equivalentTo	CD154,CD40 ligand
R1289	T1727	T1726	themeOf	expression,Enhanced
R1290	T1728	T1727	themeOf	B-cell activating factor,expression
R1291	T1729	T1728	equivalentTo	BAFF,B-cell activating factor
R1292	T1733	T1736	themeOf	High mobility group box chromosomal protein 1,released
R1293	T1733	T1735	themeOf	High mobility group box chromosomal protein 1,chromatin component
R1294	T1734	T1735	themeOf	HMGB1,chromatin component
R1295	T1734	T1733	equivalentTo	HMGB1,High mobility group box chromosomal protein 1
R1296	T1735	T1736	themeOf	chromatin component,released

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