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PMC:3218875 / 26275-27334 JSONTXT

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testone

Id Subject Object Predicate Lexical cue
T14064 488-491 Positive_regulation denotes via
T14063 455-464 Binding denotes recruited
T14062 421-428 Positive_regulation denotes induced
T14061 360-370 Gene_expression denotes expression
T14060 318-325 Gene_expression denotes produce
T14058 969-973 Protein denotes CYLD
T14057 860-864 Protein denotes RANK
T14056 831-835 Protein denotes CYLD
T14055 718-721 Protein denotes p62
T14054 621-626 Protein denotes TRAF6
T14053 587-591 Protein denotes CYLD
T14052 549-563 Protein denotes sequestosome 1
T14051 530-533 Protein denotes p62
T14050 496-505 Protein denotes ubiquitin
T14049 482-487 Protein denotes TRAF6
T14048 415-420 Protein denotes RANKL
T14047 355-359 Protein denotes CYLD
T14046 284-289 Protein denotes RANKL
T14045 145-149 Protein denotes CYLD
T14044 58-62 Protein denotes RANK
T14043 15-19 Protein denotes CYLD
R9296 T14047 T14061 themeOf CYLD,expression
R9297 T14049 T14063 themeOf TRAF6,recruited
R9298 T14052 T14063 themeOf sequestosome 1,recruited
R9299 T14052 T14064 causeOf sequestosome 1,via
R9300 T14063 T14064 themeOf recruited,via

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T15018 1058-1059 . denotes .
T15017 1056-1058 NNP denotes RA
T15016 1053-1055 IN denotes as
T15015 1048-1052 JJ denotes such
T15014 1038-1047 NNS denotes disorders
T15013 1033-1037 NN denotes bone
T15012 1030-1032 IN denotes of
T15011 1020-1029 NN denotes pathology
T15010 1016-1019 DT denotes the
T15009 1013-1015 IN denotes in
T15008 1004-1012 VBN denotes involved
T15007 997-1003 NN denotes factor
T15006 989-996 JJ denotes genetic
T15005 979-988 JJ denotes potential
T15004 977-978 DT denotes a
T15003 974-976 IN denotes as
T15002 969-973 NNP denotes CYLD
T15001 960-968 VBP denotes indicate
T15000 956-959 CC denotes and
T14999 937-955 NN denotes osteoclastogenesis
T14998 934-936 IN denotes of
T14997 923-933 NN denotes regulation
T14996 914-922 JJ denotes negative
T14995 910-913 DT denotes the
T14994 907-909 IN denotes in
T14993 902-906 NN denotes role
T14992 898-901 JJ denotes key
T14991 896-897 DT denotes a
T14990 890-895 NNS denotes plays
T14989 879-889 VBG denotes signalling
T14988 873-878 NN denotes NF-κB
T14987 860-872 JJ denotes RANK-induced
T14986 857-859 IN denotes of
T14985 845-856 NN denotes inhibi-tion
T14984 831-844 JJ denotes CYLD-mediated
T14983 826-830 IN denotes that
T14982 818-825 VBP denotes suggest
T14981 809-817 NNS denotes findings
T14980 803-808 DT denotes These
T14979 801-802 . denotes .
T14978 800-801 NNP denotes ]
T14977 798-800 CD denotes 66
T14976 797-798 NNP denotes [
T14975 792-796 NN denotes loss
T14974 787-791 NN denotes bone
T14973 775-786 JJ denotes progressive
T14972 767-774 VB denotes develop
T14971 763-766 CC denotes and
T14970 744-762 NN denotes osteoclastogenesis
T14969 735-743 JJ denotes abnormal
T14968 727-734 NN denotes display
T14967 722-726 RB denotes also
T14966 718-721 CD denotes p62
T14965 715-717 IN denotes of
T14964 710-714 NN denotes form
T14963 702-709 VBN denotes mutated
T14962 700-701 DT denotes a
T14961 689-699 VBG denotes expressing
T14960 684-688 NNS denotes mice
T14959 673-683 JJ denotes transgenic
T14958 668-672 IN denotes that
T14957 657-667 VBG denotes mentioning
T14956 651-656 JJ denotes worth
T14955 648-650 VBZ denotes is
T14954 645-647 PRP denotes it
T14953 643-644 , denotes ,
T14952 636-643 NN denotes context
T14951 631-635 DT denotes this
T14950 628-630 IN denotes In
T14949 626-627 . denotes .
T14948 621-626 CD denotes TRAF6
T14947 618-620 IN denotes of
T14946 601-617 NN denotes deubiquitination
T14945 587-600 JJ denotes CYLD-mediated
T14944 583-586 DT denotes the
T14943 580-582 IN denotes by
T14942 571-579 VBN denotes followed
T14941 569-570 , denotes ,
T14940 568-569 NNP denotes ]
T14939 566-568 CD denotes 65
T14938 565-566 NNP denotes [
T14937 563-564 -RRB- denotes )
T14936 562-563 CD denotes 1
T14935 549-561 JJ denotes sequestosome
T14934 546-548 IN denotes as
T14933 540-545 VBN denotes known
T14932 535-539 RB denotes also
T14931 534-535 -LRB- denotes (
T14930 530-533 NN denotes p62
T14929 522-529 NN denotes protein
T14928 514-521 NN denotes adaptor
T14927 496-513 JJ denotes ubiquitin-binding
T14926 492-495 DT denotes the
T14925 488-491 IN denotes via
T14924 482-487 CD denotes TRAF6
T14923 468-481 VBN denotes ubiquitinated
T14922 465-467 TO denotes to
T14921 455-464 VBN denotes recruited
T14920 452-454 VBZ denotes is
T14919 448-451 CC denotes and
T14918 429-447 NN denotes osteoclastogenesis
T14917 415-428 JJ denotes RANKL-induced
T14916 412-414 IN denotes of
T14915 401-411 NNS denotes conditions
T14914 395-400 IN denotes under
T14913 383-394 VBN denotes upregulated
T14912 374-382 RB denotes markedly
T14911 371-373 VBZ denotes is
T14910 360-370 NN denotes expression
T14909 355-359 NNP denotes CYLD
T14908 353-354 . denotes .
T14907 342-353 NNS denotes osteoclasts
T14906 335-341 JJR denotes larger
T14905 331-334 CC denotes and
T14904 326-330 JJR denotes more
T14903 318-325 VB denotes produce
T14902 314-317 CC denotes and
T14901 298-313 NN denotes differentiation
T14900 284-297 JJ denotes RANKL-induced
T14899 281-283 TO denotes to
T14898 264-280 JJ denotes hyper-responsive
T14897 260-263 VBP denotes are
T14896 255-259 NNS denotes mice
T14895 249-254 DT denotes these
T14894 246-248 IN denotes of
T14893 235-245 NNS denotes precursors
T14892 224-234 NNP denotes Osteoclast
T14891 222-223 . denotes .
T14890 210-222 NN denotes osteoporosis
T14889 203-209 JJ denotes severe
T14888 195-202 VB denotes develop
T14887 191-194 CC denotes and
T14886 175-190 NN denotes differentiation
T14885 164-174 NN denotes osteoclast
T14884 155-163 JJ denotes aberrant
T14883 150-154 VBP denotes have
T14882 145-149 NNP denotes CYLD
T14881 142-144 IN denotes of
T14880 131-141 NN denotes deficiency
T14879 123-130 JJ denotes genetic
T14878 121-122 DT denotes a
T14877 116-120 IN denotes with
T14876 111-115 NN denotes Mice
T14875 109-110 . denotes .
T14874 108-109 NNP denotes ]
T14873 106-108 CD denotes 65
T14872 105-106 NNP denotes [
T14871 100-104 NNS denotes mice
T14870 97-99 IN denotes in
T14869 78-96 NN denotes osteoclastogenesis
T14868 74-77 CC denotes and
T14867 63-73 NN denotes signalling
T14866 58-62 NNP denotes RANK
T14865 49-57 VB denotes regulate
T14864 38-48 RB denotes negatively
T14863 35-37 TO denotes to
T14862 29-34 VBN denotes shown
T14861 24-28 VBN denotes been
T14860 20-23 VBZ denotes has
T14859 15-19 NNP denotes CYLD
T14858 13-14 , denotes ,
T14857 0-13 RB denotes Interestingly
R9879 T14857 T14862 advmod Interestingly,shown
R9880 T14858 T14862 punct ",",shown
R9881 T14859 T14862 nsubjpass CYLD,shown
R9882 T14860 T14862 aux has,shown
R9883 T14861 T14862 auxpass been,shown
R9884 T14862 T14862 ROOT shown,shown
R9885 T14863 T14865 aux to,regulate
R9886 T14864 T14865 advmod negatively,regulate
R9887 T14865 T14862 xcomp regulate,shown
R9888 T14866 T14867 compound RANK,signalling
R9889 T14867 T14865 dobj signalling,regulate
R9890 T14868 T14867 cc and,signalling
R9891 T14869 T14867 conj osteoclastogenesis,signalling
R9892 T14870 T14867 prep in,signalling
R9893 T14871 T14870 pobj mice,in
R9894 T14872 T14874 nmod [,]
R9895 T14873 T14874 nummod 65,]
R9896 T14874 T14867 appos ],signalling
R9897 T14875 T14862 punct .,shown
R9898 T14876 T14883 nsubj Mice,have
R9899 T14877 T14876 prep with,Mice
R9900 T14878 T14880 det a,deficiency
R9901 T14879 T14880 amod genetic,deficiency
R9902 T14880 T14877 pobj deficiency,with
R9903 T14881 T14880 prep of,deficiency
R9904 T14882 T14881 pobj CYLD,of
R9905 T14883 T14883 ROOT have,have
R9906 T14884 T14886 amod aberrant,differentiation
R9907 T14885 T14886 compound osteoclast,differentiation
R9908 T14886 T14883 dobj differentiation,have
R9909 T14887 T14883 cc and,have
R9910 T14888 T14883 conj develop,have
R9911 T14889 T14890 amod severe,osteoporosis
R9912 T14890 T14888 dobj osteoporosis,develop
R9913 T14891 T14883 punct .,have
R9914 T14892 T14897 dep Osteoclast,are
R9915 T14893 T14897 nsubj precursors,are
R9916 T14894 T14893 prep of,precursors
R9917 T14895 T14896 det these,mice
R9918 T14896 T14894 pobj mice,of
R9919 T14897 T14897 ROOT are,are
R9920 T14898 T14897 acomp hyper-responsive,are
R9921 T14899 T14898 prep to,hyper-responsive
R9922 T14900 T14901 amod RANKL-induced,differentiation
R9923 T14901 T14899 pobj differentiation,to
R9924 T14902 T14897 cc and,are
R9925 T14903 T14897 conj produce,are
R9926 T14904 T14907 amod more,osteoclasts
R9927 T14905 T14904 cc and,more
R9928 T14906 T14904 conj larger,more
R9929 T14907 T14903 dobj osteoclasts,produce
R9930 T14908 T14897 punct .,are
R9931 T14909 T14910 compound CYLD,expression
R9932 T14910 T14913 nsubjpass expression,upregulated
R9933 T14911 T14913 auxpass is,upregulated
R9934 T14912 T14913 advmod markedly,upregulated
R9935 T14913 T14913 ROOT upregulated,upregulated
R9936 T14914 T14913 prep under,upregulated
R9937 T14915 T14914 pobj conditions,under
R9938 T14916 T14915 prep of,conditions
R9939 T14917 T14918 compound RANKL-induced,osteoclastogenesis
R9940 T14918 T14916 pobj osteoclastogenesis,of
R9941 T14919 T14913 cc and,upregulated
R9942 T14920 T14921 auxpass is,recruited
R9943 T14921 T14913 conj recruited,upregulated
R9944 T14922 T14921 prep to,recruited
R9945 T14923 T14924 amod ubiquitinated,TRAF6
R9946 T14924 T14922 pobj TRAF6,to
R9947 T14925 T14921 prep via,recruited
R9948 T14926 T14929 det the,protein
R9949 T14927 T14929 amod ubiquitin-binding,protein
R9955 T14933 T14930 acl known,p62
R9956 T14934 T14933 prep as,known
R9957 T14935 T14934 pobj sequestosome,as
R9958 T14936 T14935 nummod 1,sequestosome
R9959 T14937 T14930 punct ),p62
R9960 T14938 T14940 nmod [,]
R9961 T14939 T14940 nummod 65,]
R9962 T14940 T14940 ROOT ],]
R9963 T14941 T14940 punct ",",]
R9964 T14942 T14940 acl followed,]
R9965 T14943 T14942 agent by,followed
R9966 T14944 T14946 det the,deubiquitination
R9967 T14945 T14946 amod CYLD-mediated,deubiquitination
R9968 T14946 T14943 pobj deubiquitination,by
R9969 T14947 T14946 prep of,deubiquitination
R9970 T14948 T14947 pobj TRAF6,of
R9971 T14949 T14913 punct .,upregulated
R9972 T14950 T14955 prep In,is
R9973 T14951 T14952 det this,context
R9974 T14952 T14950 pobj context,In
R9975 T14953 T14955 punct ",",is
R9976 T14954 T14955 nsubj it,is
R9977 T14955 T14955 ROOT is,is
R9978 T14956 T14955 acomp worth,is
R9979 T14957 T14956 xcomp mentioning,worth
R9980 T14958 T14968 mark that,display
R9981 T14959 T14960 amod transgenic,mice
R9982 T14960 T14968 nsubj mice,display
R9983 T14961 T14960 acl expressing,mice
R9984 T14962 T14964 det a,form
R9985 T14963 T14964 amod mutated,form
R9986 T14964 T14961 dobj form,expressing
R9987 T14965 T14964 prep of,form
R9988 T14966 T14965 pobj p62,of
R9989 T14967 T14968 advmod also,display
R9990 T14968 T14955 ccomp display,is
R9991 T14969 T14970 amod abnormal,osteoclastogenesis
R9992 T14970 T14968 dobj osteoclastogenesis,display
R9993 T14971 T14968 cc and,display
R9994 T14972 T14968 conj develop,display
R9995 T14973 T14975 amod progressive,loss
R9996 T14974 T14975 compound bone,loss
R9997 T14975 T14972 dobj loss,develop
R9998 T14976 T14978 nmod [,]
R9999 T14977 T14978 nummod 66,]
R10000 T14978 T14975 appos ],loss
R10001 T14979 T14955 punct .,is
R10002 T14980 T14981 det These,findings
R10003 T14981 T14982 nsubj findings,suggest
R10004 T14982 T14982 ROOT suggest,suggest
R10005 T14983 T15001 mark that,indicate
R10006 T14984 T14985 amod CYLD-mediated,inhibi-tion
R10007 T14985 T15001 nsubj inhibi-tion,indicate
R10008 T14986 T14985 prep of,inhibi-tion
R10009 T14987 T14988 amod RANK-induced,NF-κB
R10010 T14988 T14989 nsubj NF-κB,signalling
R10011 T14989 T14986 pcomp signalling,of
R10012 T14990 T14989 dobj plays,signalling
R10013 T14991 T14993 det a,role
R10014 T14992 T14993 amod key,role
R10015 T14993 T14989 oprd role,signalling
R10016 T14994 T14993 prep in,role
R10017 T14995 T14997 det the,regulation
R10018 T14996 T14997 amod negative,regulation
R10019 T14997 T14994 pobj regulation,in
R10020 T14998 T14997 prep of,regulation
R10021 T14999 T14998 pobj osteoclastogenesis,of
R10022 T15000 T14989 cc and,signalling
R10023 T15001 T14982 ccomp indicate,suggest
R10029 T15007 T15003 pobj factor,as
R10030 T15008 T15007 acl involved,factor
R10031 T15009 T15008 prep in,involved
R10032 T15010 T15011 det the,pathology
R10033 T15011 T15009 pobj pathology,in
R10034 T15012 T15011 prep of,pathology
R10035 T15013 T15014 compound bone,disorders
R10036 T15014 T15012 pobj disorders,of
R10037 T15015 T15016 amod such,as
R10038 T15016 T15014 prep as,disorders
R10039 T15017 T15016 pobj RA,as
R10040 T15018 T14982 punct .,suggest
R9950 T14928 T14929 compound adaptor,protein
R9951 T14929 T14925 pobj protein,via
R9952 T14930 T14921 conj p62,recruited
R9953 T14931 T14933 punct (,known
R9954 T14932 T14933 advmod also,known
R10024 T15002 T15001 dobj CYLD,indicate
R10025 T15003 T15001 prep as,indicate
R10026 T15004 T15007 det a,factor
R10027 T15005 T15007 amod potential,factor
R10028 T15006 T15007 amod genetic,factor

DLUT931

Id Subject Object Predicate Lexical cue
T15108 360-370 Gene_expression denotes expression
T15107 131-141 Negative_regulation denotes deficiency
T15105 969-973 Protein denotes CYLD
T15104 860-864 Protein denotes RANK
T15103 831-835 Protein denotes CYLD
T15102 718-721 Protein denotes p62
T15101 621-626 Protein denotes TRAF6
T15100 587-591 Protein denotes CYLD
T15099 549-563 Protein denotes sequestosome 1
T15098 530-533 Protein denotes p62
T15097 496-505 Protein denotes ubiquitin
T15096 482-487 Protein denotes TRAF6
T15095 415-420 Protein denotes RANKL
T15094 355-359 Protein denotes CYLD
T15093 284-289 Protein denotes RANKL
T15092 145-149 Protein denotes CYLD
T15091 58-62 Protein denotes RANK
T15090 15-19 Protein denotes CYLD
T15114 689-699 Gene_expression denotes expressing
T15113 601-617 Negative_regulation denotes deubiquitination
T15112 506-513 Binding denotes binding
T15111 468-481 Positive_regulation denotes ubiquitinated
T15110 455-464 Binding denotes recruited
T15109 383-394 Positive_regulation denotes upregulated
R10052 T15092 T15107 themeOf CYLD,deficiency
R10053 T15094 T15108 themeOf CYLD,expression
R10054 T15096 T15110 themeOf TRAF6,recruited
R10055 T15096 T15111 themeOf TRAF6,ubiquitinated
R10056 T15097 T15112 themeOf ubiquitin,binding
R10057 T15098 T15110 themeOf p62,recruited
R10058 T15098 T15112 themeOf p62,binding
R10059 T15101 T15113 themeOf TRAF6,deubiquitination
R10060 T15102 T15114 themeOf p62,expressing
R10061 T15108 T15109 themeOf expression,upregulated

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T15028 549-563 http://www.uniprot.org/uniprot/Q13501 denotes sequestosome 1
T15023 621-626 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TRAF6
T15022 482-487 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TRAF6

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T14243 969-973 Protein denotes CYLD
T14242 860-864 Protein denotes RANK
T14241 831-835 Protein denotes CYLD
T14240 718-721 Protein denotes p62
T14239 621-626 Protein denotes TRAF6
T14238 587-591 Protein denotes CYLD
T14237 549-563 Protein denotes sequestosome 1
T14236 530-533 Protein denotes p62
T14235 496-505 Protein denotes ubiquitin
T14234 482-487 Protein denotes TRAF6
T14233 415-420 Protein denotes RANKL
T14232 355-359 Protein denotes CYLD
T14231 284-289 Protein denotes RANKL
T14230 145-149 Protein denotes CYLD
T14229 58-62 Protein denotes RANK
T14228 15-19 Protein denotes CYLD

2_test

Id Subject Object Predicate Lexical cue
21639951-18382763-4289495 106-108 18382763 denotes 65
21639951-18382763-4289496 566-568 18382763 denotes 65
21639951-17187080-4289497 798-800 17187080 denotes 66

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T14577 1056-1058 NN denotes RA
T14576 1053-1055 IN denotes as
T14575 1048-1052 JJ denotes such
T14574 1038-1047 NN denotes disorders
T14573 1033-1037 NN denotes bone
T14572 1030-1032 IN denotes of
T14571 1020-1029 NN denotes pathology
T14570 1016-1019 DT denotes the
T14569 1013-1015 IN denotes in
T14568 1004-1012 VB denotes involved
T14567 997-1003 NN denotes factor
T14566 989-996 JJ denotes genetic
T14565 979-988 JJ denotes potential
T14564 977-978 DT denotes a
T14563 974-976 IN denotes as
T14562 969-973 NN denotes CYLD
T14561 960-968 VB denotes indicate
T14560 956-959 CC denotes and
T14559 937-955 NN denotes osteoclastogenesis
T14558 934-936 IN denotes of
T14557 923-933 NN denotes regulation
T14556 914-922 JJ denotes negative
T14555 910-913 DT denotes the
T14554 907-909 IN denotes in
T14553 902-906 NN denotes role
T14552 898-901 JJ denotes key
T14551 896-897 DT denotes a
T14550 890-895 VB denotes plays
T14549 879-889 NN denotes signalling
T14548 873-878 NN denotes NF-κB
T14547 860-872 JJ denotes RANK-induced
T14546 857-859 IN denotes of
T14545 845-856 NN denotes inhibi-tion
T14544 831-844 JJ denotes CYLD-mediated
T14543 826-830 IN denotes that
T14542 818-825 VB denotes suggest
T14541 809-817 NN denotes findings
T14540 803-808 DT denotes These
T14539 800-801 -RRB- denotes ]
T14538 798-800 CD denotes 66
T14537 797-798 -LRB- denotes [
T14536 792-796 NN denotes loss
T14535 787-791 NN denotes bone
T14534 775-786 JJ denotes progressive
T14533 767-774 VB denotes develop
T14532 763-766 CC denotes and
T14531 744-762 NN denotes osteoclastogenesis
T14530 735-743 JJ denotes abnormal
T14529 727-734 VB denotes display
T14528 722-726 RB denotes also
T14527 718-721 NN denotes p62
T14526 715-717 IN denotes of
T14525 710-714 NN denotes form
T14524 702-709 VB denotes mutated
T14523 700-701 DT denotes a
T14522 689-699 VB denotes expressing
T14521 684-688 NN denotes mice
T14520 673-683 JJ denotes transgenic
T14519 668-672 IN denotes that
T14518 657-667 VB denotes mentioning
T14517 651-656 JJ denotes worth
T14516 648-650 VB denotes is
T14515 645-647 PRP denotes it
T14514 643-644 -COMMA- denotes ,
T14513 636-643 NN denotes context
T14512 631-635 DT denotes this
T14511 628-630 IN denotes In
T14510 621-626 NN denotes TRAF6
T14509 618-620 IN denotes of
T14508 601-617 NN denotes deubiquitination
T14507 587-600 JJ denotes CYLD-mediated
T14506 583-586 DT denotes the
T14505 580-582 IN denotes by
T14504 571-579 VB denotes followed
T14503 569-570 -COMMA- denotes ,
T14502 568-569 -RRB- denotes ]
T14501 566-568 CD denotes 65
T14500 565-566 -LRB- denotes [
T14499 563-564 -RRB- denotes )
T14498 562-563 CD denotes 1
T14497 549-561 NN denotes sequestosome
T14496 546-548 IN denotes as
T14495 540-545 VB denotes known
T14494 535-539 RB denotes also
T14493 534-535 -LRB- denotes (
T14492 530-533 NN denotes p62
T14491 522-529 NN denotes protein
T14490 514-521 NN denotes adaptor
T14489 496-513 JJ denotes ubiquitin-binding
T14488 492-495 DT denotes the
T14487 488-491 IN denotes via
T14486 482-487 NN denotes TRAF6
T14485 468-481 VB denotes ubiquitinated
T14484 465-467 TO denotes to
T14483 455-464 VB denotes recruited
T14482 452-454 VB denotes is
T14481 448-451 CC denotes and
T14480 429-447 NN denotes osteoclastogenesis
T14479 415-428 JJ denotes RANKL-induced
T14478 412-414 IN denotes of
T14477 401-411 NN denotes conditions
T14476 395-400 IN denotes under
T14475 383-394 VB denotes upregulated
T14474 374-382 RB denotes markedly
T14473 371-373 VB denotes is
T14472 360-370 NN denotes expression
T14471 355-359 NN denotes CYLD
T14470 342-353 NN denotes osteoclasts
T14469 335-341 JJ denotes larger
T14468 331-334 CC denotes and
T14467 326-330 JJ denotes more
T14466 318-325 VB denotes produce
T14465 314-317 CC denotes and
T14464 298-313 NN denotes differentiation
T14463 284-297 JJ denotes RANKL-induced
T14462 281-283 TO denotes to
T14461 264-280 JJ denotes hyper-responsive
T14460 260-263 VB denotes are
T14459 255-259 NN denotes mice
T14458 249-254 DT denotes these
T14457 246-248 IN denotes of
T14456 235-245 NN denotes precursors
T14455 224-234 NN denotes Osteoclast
T14454 210-222 NN denotes osteoporosis
T14453 203-209 JJ denotes severe
T14452 195-202 VB denotes develop
T14451 191-194 CC denotes and
T14450 175-190 NN denotes differentiation
T14449 164-174 NN denotes osteoclast
T14448 155-163 JJ denotes aberrant
T14447 150-154 VB denotes have
T14446 145-149 NN denotes CYLD
T14445 142-144 IN denotes of
T14444 131-141 NN denotes deficiency
T14443 123-130 JJ denotes genetic
T14442 121-122 DT denotes a
T14441 116-120 IN denotes with
T14440 111-115 NN denotes Mice
T14439 108-109 -RRB- denotes ]
T14438 106-108 CD denotes 65
T14437 105-106 -LRB- denotes [
T14436 100-104 NN denotes mice
T14435 97-99 IN denotes in
T14434 78-96 NN denotes osteoclastogenesis
T14433 74-77 CC denotes and
T14432 63-73 NN denotes signalling
T14431 58-62 NN denotes RANK
T14430 49-57 VB denotes regulate
T14429 38-48 RB denotes negatively
T14428 35-37 TO denotes to
T14427 29-34 VB denotes shown
T14426 24-28 VB denotes been
T14425 20-23 VB denotes has
T14424 15-19 NN denotes CYLD
T14423 13-14 -COMMA- denotes ,
T14422 0-13 RB denotes Interestingly
R9626 T14515 T14516 arg1Of it,is
R9627 T14515 T14517 arg1Of it,worth
R9628 T14516 T14511 arg1Of is,In
R9529 T14424 T14425 arg1Of CYLD,has
R9530 T14424 T14426 arg1Of CYLD,been
R9531 T14424 T14427 arg2Of CYLD,shown
R9532 T14424 T14430 arg1Of CYLD,regulate
R9533 T14427 T14422 arg1Of shown,Interestingly
R9534 T14427 T14423 arg1Of shown,","
R9535 T14427 T14425 arg2Of shown,has
R9536 T14427 T14426 arg2Of shown,been
R9537 T14430 T14427 arg3Of regulate,shown
R9538 T14430 T14428 arg1Of regulate,to
R9539 T14430 T14429 arg1Of regulate,negatively
R9540 T14432 T14431 arg1Of signalling,RANK
R9541 T14432 T14433 arg1Of signalling,and
R9542 T14433 T14430 arg2Of and,regulate
R9543 T14433 T14435 arg1Of and,in
R9544 T14434 T14433 arg2Of osteoclastogenesis,and
R9545 T14436 T14435 arg2Of mice,in
R9546 T14436 T14437 arg1Of mice,[
R9547 T14438 T14437 arg2Of 65,[
R9548 T14439 T14437 arg3Of ],[
R9549 T14440 T14441 arg1Of Mice,with
R9550 T14440 T14447 arg1Of Mice,have
R9551 T14440 T14452 arg1Of Mice,develop
R9552 T14444 T14441 arg2Of deficiency,with
R9553 T14444 T14442 arg1Of deficiency,a
R9554 T14444 T14443 arg1Of deficiency,genetic
R9555 T14444 T14445 arg1Of deficiency,of
R9556 T14446 T14445 arg2Of CYLD,of
R9557 T14447 T14451 arg1Of have,and
R9558 T14450 T14447 arg2Of differentiation,have
R9559 T14450 T14448 arg1Of differentiation,aberrant
R9560 T14450 T14449 arg1Of differentiation,osteoclast
R9561 T14452 T14451 arg2Of develop,and
R9562 T14454 T14452 arg2Of osteoporosis,develop
R9563 T14454 T14453 arg1Of osteoporosis,severe
R9564 T14456 T14455 arg1Of precursors,Osteoclast
R9565 T14456 T14457 arg1Of precursors,of
R9566 T14456 T14460 arg1Of precursors,are
R9567 T14456 T14461 arg1Of precursors,hyper-responsive
R9568 T14456 T14466 arg1Of precursors,produce
R9569 T14459 T14457 arg2Of mice,of
R9570 T14459 T14458 arg1Of mice,these
R9571 T14460 T14465 arg1Of are,and
R9572 T14461 T14460 arg2Of hyper-responsive,are
R9573 T14461 T14462 arg1Of hyper-responsive,to
R9574 T14464 T14462 arg2Of differentiation,to
R9575 T14464 T14463 arg1Of differentiation,RANKL-induced
R9576 T14466 T14465 arg2Of produce,and
R9577 T14467 T14468 arg1Of more,and
R9578 T14469 T14468 arg2Of larger,and
R9579 T14470 T14466 arg2Of osteoclasts,produce
R9580 T14470 T14467 arg1Of osteoclasts,more
R9581 T14470 T14469 arg1Of osteoclasts,larger
R9582 T14472 T14471 arg1Of expression,CYLD
R9583 T14472 T14473 arg1Of expression,is
R9584 T14472 T14475 arg2Of expression,upregulated
R9585 T14472 T14482 arg1Of expression,is
R9586 T14472 T14483 arg2Of expression,recruited
R9587 T14475 T14473 arg2Of upregulated,is
R9588 T14475 T14474 arg1Of upregulated,markedly
R9589 T14475 T14476 arg1Of upregulated,under
R9590 T14475 T14481 arg1Of upregulated,and
R9591 T14477 T14476 arg2Of conditions,under
R9592 T14477 T14478 arg1Of conditions,of
R9593 T14480 T14478 arg2Of osteoclastogenesis,of
R9594 T14480 T14479 arg1Of osteoclastogenesis,RANKL-induced
R9595 T14481 T14503 arg1Of and,","
R9596 T14481 T14504 modOf and,followed
R9597 T14483 T14481 arg2Of recruited,and
R9598 T14483 T14482 arg2Of recruited,is
R9599 T14483 T14484 arg1Of recruited,to
R9600 T14483 T14487 arg1Of recruited,via
R9601 T14483 T14500 arg1Of recruited,[
R9602 T14486 T14484 arg2Of TRAF6,to
R9603 T14486 T14485 arg2Of TRAF6,ubiquitinated
R9604 T14492 T14487 arg2Of p62,via
R9605 T14492 T14488 arg1Of p62,the
R9606 T14492 T14489 arg1Of p62,ubiquitin-binding
R9607 T14492 T14490 arg1Of p62,adaptor
R9608 T14492 T14491 arg1Of p62,protein
R9609 T14492 T14493 arg1Of p62,(
R9610 T14495 T14493 arg2Of known,(
R9611 T14495 T14494 arg1Of known,also
R9612 T14495 T14496 arg1Of known,as
R9613 T14497 T14496 arg2Of sequestosome,as
R9614 T14497 T14498 arg1Of sequestosome,1
R9615 T14499 T14493 arg3Of ),(
R9616 T14501 T14500 arg2Of 65,[
R9617 T14502 T14500 arg3Of ],[
R9618 T14508 T14504 arg1Of deubiquitination,followed
R9619 T14508 T14505 arg2Of deubiquitination,by
R9620 T14508 T14506 arg1Of deubiquitination,the
R9621 T14508 T14507 arg1Of deubiquitination,CYLD-mediated
R9622 T14508 T14509 arg1Of deubiquitination,of
R9623 T14510 T14509 arg2Of TRAF6,of
R9624 T14513 T14511 arg2Of context,In
R9625 T14513 T14512 arg1Of context,this
R9629 T14516 T14514 arg1Of is,","
R9630 T14517 T14516 arg2Of worth,is
R9631 T14518 T14517 arg2Of mentioning,worth
R9632 T14521 T14520 arg1Of mice,transgenic
R9633 T14521 T14522 arg1Of mice,expressing
R9634 T14521 T14529 arg1Of mice,display
R9635 T14521 T14533 arg1Of mice,develop
R9636 T14525 T14522 arg2Of form,expressing
R9637 T14525 T14523 arg1Of form,a
R9638 T14525 T14524 arg2Of form,mutated
R9639 T14525 T14526 arg1Of form,of
R9640 T14527 T14526 arg2Of p62,of
R9641 T14529 T14532 arg1Of display,and
R9642 T14531 T14529 arg2Of osteoclastogenesis,display
R9643 T14531 T14530 arg1Of osteoclastogenesis,abnormal
R9644 T14532 T14518 arg2Of and,mentioning
R9645 T14532 T14519 arg1Of and,that
R9646 T14532 T14528 arg1Of and,also
R9647 T14533 T14532 arg2Of develop,and
R9648 T14533 T14537 arg1Of develop,[
R9649 T14536 T14533 arg2Of loss,develop
R9650 T14536 T14534 arg1Of loss,progressive
R9651 T14536 T14535 arg1Of loss,bone
R9652 T14538 T14537 arg2Of 66,[
R9653 T14539 T14537 arg3Of ],[
R9654 T14541 T14540 arg1Of findings,These
R9655 T14541 T14542 arg1Of findings,suggest
R9656 T14545 T14544 arg1Of inhibi-tion,CYLD-mediated
R9657 T14545 T14546 arg1Of inhibi-tion,of
R9658 T14545 T14550 arg1Of inhibi-tion,plays
R9659 T14545 T14561 arg1Of inhibi-tion,indicate
R9660 T14549 T14546 arg2Of signalling,of
R9661 T14549 T14547 arg1Of signalling,RANK-induced
R9662 T14549 T14548 arg1Of signalling,NF-κB
R9663 T14550 T14554 arg1Of plays,in
R9664 T14550 T14560 arg1Of plays,and
R9665 T14553 T14550 arg2Of role,plays
R9666 T14553 T14551 arg1Of role,a
R9667 T14553 T14552 arg1Of role,key
R9668 T14557 T14554 arg2Of regulation,in
R9669 T14557 T14555 arg1Of regulation,the
R9670 T14557 T14556 arg1Of regulation,negative
R9671 T14557 T14558 arg1Of regulation,of
R9672 T14559 T14558 arg2Of osteoclastogenesis,of
R9673 T14560 T14542 arg2Of and,suggest
R9674 T14560 T14543 arg1Of and,that
R9675 T14561 T14560 arg2Of indicate,and
R9676 T14561 T14563 arg1Of indicate,as
R9677 T14562 T14561 arg2Of CYLD,indicate
R9678 T14567 T14563 arg2Of factor,as
R9679 T14567 T14564 arg1Of factor,a
R9680 T14567 T14565 arg1Of factor,potential
R9681 T14567 T14566 arg1Of factor,genetic
R9682 T14567 T14568 arg2Of factor,involved
R9683 T14568 T14569 arg1Of involved,in
R9684 T14571 T14569 arg2Of pathology,in
R9685 T14571 T14570 arg1Of pathology,the
R9686 T14571 T14572 arg1Of pathology,of
R9687 T14574 T14572 arg2Of disorders,of
R9688 T14574 T14573 arg1Of disorders,bone
R9689 T14574 T14576 arg1Of disorders,as
R9690 T14576 T14575 arg1Of as,such
R9691 T14577 T14576 arg2Of RA,as

GO-BP

Id Subject Object Predicate Lexical cue
T14593 923-933 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T14592 601-617 http://purl.obolibrary.org/obo/GO_0016579 denotes deubiquitination
T14591 164-190 http://purl.obolibrary.org/obo/GO_0030316 denotes osteoclast differentiation
T14589 879-889 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T14588 63-73 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling

GO-MF

Id Subject Object Predicate Lexical cue
T14599 506-513 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T14598 496-513 http://purl.obolibrary.org/obo/GO_0043130 denotes ubiquitin-binding
T14597 496-505 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin

sentences

Id Subject Object Predicate Lexical cue
T14151 803-1059 Sentence denotes These findings suggest that CYLD-mediated inhibi-tion of RANK-induced NF-κB signalling plays a key role in the negative regulation of osteoclastogenesis and indicate CYLD as a potential genetic factor involved in the pathology of bone disorders such as RA.
T14150 628-802 Sentence denotes In this context, it is worth mentioning that transgenic mice expressing a mutated form of p62 also display abnormal osteoclastogenesis and develop progressive bone loss [66].
T14149 355-627 Sentence denotes CYLD expression is markedly upregulated under conditions of RANKL-induced osteoclastogenesis and is recruited to ubiquitinated TRAF6 via the ubiquitin-binding adaptor protein p62 (also known as sequestosome 1) [65], followed by the CYLD-mediated deubiquitination of TRAF6.
T14148 224-354 Sentence denotes Osteoclast precursors of these mice are hyper-responsive to RANKL-induced differentiation and produce more and larger osteoclasts.
T14147 111-223 Sentence denotes Mice with a genetic deficiency of CYLD have aberrant osteoclast differentiation and develop severe osteoporosis.
T14146 0-110 Sentence denotes Interestingly, CYLD has been shown to negatively regulate RANK signalling and osteoclastogenesis in mice [65].
T146 0-110 Sentence denotes Interestingly, CYLD has been shown to negatively regulate RANK signalling and osteoclastogenesis in mice [65].
T147 111-223 Sentence denotes Mice with a genetic deficiency of CYLD have aberrant osteoclast differentiation and develop severe osteoporosis.
T148 224-354 Sentence denotes Osteoclast precursors of these mice are hyper-responsive to RANKL-induced differentiation and produce more and larger osteoclasts.
T149 355-627 Sentence denotes CYLD expression is markedly upregulated under conditions of RANKL-induced osteoclastogenesis and is recruited to ubiquitinated TRAF6 via the ubiquitin-binding adaptor protein p62 (also known as sequestosome 1) [65], followed by the CYLD-mediated deubiquitination of TRAF6.
T150 628-802 Sentence denotes In this context, it is worth mentioning that transgenic mice expressing a mutated form of p62 also display abnormal osteoclastogenesis and develop progressive bone loss [66].
T151 803-1059 Sentence denotes These findings suggest that CYLD-mediated inhibi-tion of RANK-induced NF-κB signalling plays a key role in the negative regulation of osteoclastogenesis and indicate CYLD as a potential genetic factor involved in the pathology of bone disorders such as RA.

ICD10

Id Subject Object Predicate Lexical cue
T14595 1033-1047 http://purl.bioontology.org/ontology/ICD10/M89.9 denotes bone disorders
T14594 210-222 http://purl.bioontology.org/ontology/ICD10/M81.9 denotes osteoporosis

simple1

Id Subject Object Predicate Lexical cue
T14638 969-973 Protein denotes CYLD
T14637 860-864 Protein denotes RANK
T14636 831-835 Protein denotes CYLD
T14635 718-721 Protein denotes p62
T14634 621-626 Protein denotes TRAF6
T14633 587-591 Protein denotes CYLD
T14632 549-563 Protein denotes sequestosome 1
T14631 530-533 Protein denotes p62
T14630 496-505 Protein denotes ubiquitin
T14629 482-487 Protein denotes TRAF6
T14628 415-420 Protein denotes RANKL
T14627 355-359 Protein denotes CYLD
T14626 284-289 Protein denotes RANKL
T14625 145-149 Protein denotes CYLD
T14624 58-62 Protein denotes RANK
T14623 15-19 Protein denotes CYLD

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T15301 689-699 Gene_expression denotes expressing
T15300 360-370 Gene_expression denotes expression
T15299 506-513 Binding denotes binding
T15298 601-617 Negative_regulation denotes deubiquitination
T15297 383-394 Positive_regulation denotes upregulated
T15296 131-141 Negative_regulation denotes deficiency
T15293 969-973 Protein denotes CYLD
T15292 860-864 Protein denotes RANK
T15291 831-835 Protein denotes CYLD
T15290 718-721 Protein denotes p62
T15289 621-626 Protein denotes TRAF6
T15288 587-591 Protein denotes CYLD
T15287 549-563 Protein denotes sequestosome 1
T15286 530-533 Protein denotes p62
T15285 496-505 Protein denotes ubiquitin
T15284 482-487 Protein denotes TRAF6
T15283 415-420 Protein denotes RANKL
T15282 355-359 Protein denotes CYLD
T15281 284-289 Protein denotes RANKL
T15280 145-149 Protein denotes CYLD
T15279 58-62 Protein denotes RANK
T15278 15-19 Protein denotes CYLD
R10135 T15280 T15296 themeOf CYLD,deficiency
R10136 T15282 T15300 themeOf CYLD,expression
R10137 T15285 T15299 themeOf ubiquitin,binding
R10138 T15286 T15299 themeOf p62,binding
R10139 T15286 T15300 themeOf p62,expression
R10140 T15289 T15298 themeOf TRAF6,deubiquitination
R10141 T15290 T15301 themeOf p62,expressing
R10142 T15300 T15297 themeOf expression,upregulated
R10143 T15300 T15297 themeOf expression,upregulated

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T15071 689-699 Gene_expression denotes expressing
T15069 383-394 Positive_regulation denotes upregulated
T15068 455-464 Binding denotes recruited
T15067 601-617 Negative_regulation denotes deubiquitination
T15066 360-370 Gene_expression denotes expression
T15065 290-297 Positive_regulation denotes induced
T15064 131-141 Negative_regulation denotes deficiency
T15062 969-973 Protein denotes CYLD
T15061 860-864 Protein denotes RANK
T15060 831-835 Protein denotes CYLD
T15059 718-721 Protein denotes p62
T15058 621-626 Protein denotes TRAF6
T15057 587-591 Protein denotes CYLD
T15056 549-563 Protein denotes sequestosome 1
T15055 530-533 Protein denotes p62
T15054 496-505 Protein denotes ubiquitin
T15053 482-487 Protein denotes TRAF6
T15052 415-420 Protein denotes RANKL
T15051 355-359 Protein denotes CYLD
T15050 284-289 Protein denotes RANKL
T15049 145-149 Protein denotes CYLD
T15048 58-62 Protein denotes RANK
T15047 15-19 Protein denotes CYLD
T15070 506-513 Binding denotes binding
R10042 T15049 T15064 themeOf CYLD,deficiency
R10043 T15050 T15065 themeOf RANKL,induced
R10044 T15051 T15066 themeOf CYLD,expression
R10045 T15054 T15070 themeOf ubiquitin,binding
R10046 T15055 T15068 themeOf p62,recruited
R10047 T15055 T15070 themeOf p62,binding
R10048 T15058 T15067 themeOf TRAF6,deubiquitination
R10049 T15059 T15071 themeOf p62,expressing
R10050 T15066 T15069 themeOf expression,upregulated

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue
T15367 468-487 Ubiquitination denotes ubiquitinated TRAF6
T15365 0-109 Regulation denotes Interestingly, CYLD has been shown to negatively regulate RANK signalling and osteoclastogenesis in mice [65]
T15362 580-626 Regulation denotes by the CYLD-mediated deubiquitination of TRAF6
T15361 355-370 Gene_expression denotes CYLD expression
T15357 415-428 Protein denotes RANKL-induced
T15356 831-844 Protein denotes CYLD-mediated
T15353 715-721 Protein denotes of p62
T15352 224-259 Entity denotes Osteoclast precursors of these mice
T15351 1033-1058 Protein denotes bone disorders such as RA
T15346 969-973 Protein denotes CYLD
T15345 58-109 Protein denotes RANK signalling and osteoclastogenesis in mice [65]
T15343 15-19 Protein denotes CYLD
T15341 549-563 Protein denotes sequestosome 1
T15337 142-149 Protein denotes of CYLD
T15334 618-626 Protein denotes of TRAF6
T15330 468-487 Protein denotes ubiquitinated TRAF6
T15327 860-889 Protein denotes RANK-induced NF-κB signalling
T15326 335-353 Entity denotes larger osteoclasts
T15325 514-533 Protein denotes adaptor protein p62
T15323 111-149 Protein denotes Mice with a genetic deficiency of CYLD
T15322 860-872 Protein denotes RANK-induced
T15320 514-533 Protein denotes adaptor protein p62
T15318 492-513 Protein denotes the ubiquitin-binding
T15314 355-359 Protein denotes CYLD
T15312 587-600 Protein denotes CYLD-mediated
T15311 284-289 Protein denotes RANKL
T15303 100-109 Protein denotes mice [65]
R10148 T15312 T15362 causeOf CYLD-mediated,by the CYLD-mediated deubiquitination of TRAF6
R10149 T15314 T15361 themeOf CYLD,CYLD expression
R10151 T15330 T15367 themeOf ubiquitinated TRAF6,ubiquitinated TRAF6
R10153 T15343 T15365 causeOf CYLD,"Interestingly, CYLD has been shown to negatively regulate RANK signalling and osteoclastogenesis in mice [65]"
R10154 T15345 T15365 themeOf RANK signalling and osteoclastogenesis in mice [65],"Interestingly, CYLD has been shown to negatively regulate RANK signalling and osteoclastogenesis in mice [65]"

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T15167 969-973 Protein denotes CYLD
T15166 873-878 Protein denotes NF-κB
T15165 860-864 Protein denotes RANK
T15164 689-699 Gene_expression denotes expressing
T15163 718-721 Protein denotes p62
T15162 455-464 Negative_regulation denotes recruited
T15161 383-394 Positive_regulation denotes upregulated
T15160 360-370 Gene_expression denotes expression
T15159 621-626 Protein denotes TRAF6
T15158 530-533 Protein denotes p62
T15157 496-505 Protein denotes ubiquitin
T15156 468-487 Protein denotes ubiquitinated TRAF6
T15155 415-420 Protein denotes RANKL
T15154 355-359 Protein denotes CYLD
T15153 284-289 Protein denotes RANKL
T15152 131-141 Negative_regulation denotes deficiency
T15151 145-149 Protein denotes CYLD
T15150 49-57 Regulation denotes regulate
T15149 58-62 Protein denotes RANK
T15148 15-19 Protein denotes CYLD
R10087 T15149 T15150 themeOf RANK,regulate
R10088 T15150 T15148 Cause regulate,CYLD
R10089 T15151 T15152 themeOf CYLD,deficiency
R10090 T15154 T15160 themeOf CYLD,expression
R10091 T15160 T15161 themeOf expression,upregulated
R10092 T15160 T15162 themeOf expression,recruited
R10093 T15163 T15164 themeOf p62,expressing

test3

Id Subject Object Predicate Lexical cue
T14138 969-973 Protein denotes CYLD
T14137 860-864 Protein denotes RANK
T14136 831-835 Protein denotes CYLD
T14135 718-721 Protein denotes p62
T14134 621-626 Protein denotes TRAF6
T14133 592-600 Positive_regulation denotes mediated
T14132 587-591 Protein denotes CYLD
T14131 549-563 Protein denotes sequestosome 1
T14130 530-533 Protein denotes p62
T14129 506-513 Binding denotes binding
T14128 496-505 Protein denotes ubiquitin
T14127 488-491 Positive_regulation denotes via
T14126 482-487 Protein denotes TRAF6
T14125 455-464 Binding denotes recruited
T14124 421-428 Positive_regulation denotes induced
T14123 415-420 Protein denotes RANKL
T14122 355-359 Protein denotes CYLD
T14121 284-289 Protein denotes RANKL
T14120 145-149 Protein denotes CYLD
T14119 58-62 Protein denotes RANK
T14118 15-19 Protein denotes CYLD
T14098 969-973 Protein denotes CYLD
T14097 860-864 Protein denotes RANK
T14096 831-835 Protein denotes CYLD
T14095 718-721 Protein denotes p62
T14094 621-626 Protein denotes TRAF6
T14093 587-591 Protein denotes CYLD
T14092 549-563 Protein denotes sequestosome 1
T14091 530-533 Protein denotes p62
T14090 496-505 Protein denotes ubiquitin
T14089 482-487 Protein denotes TRAF6
T14088 415-420 Protein denotes RANKL
T14087 355-359 Protein denotes CYLD
T14086 284-289 Protein denotes RANKL
T14085 145-149 Protein denotes CYLD
T14084 58-62 Protein denotes RANK
T14083 15-19 Protein denotes CYLD
R9306 T14118 T14119 themeOf CYLD,RANK
R9307 T14123 T14124 causeOf RANKL,induced
R9308 T14126 T14125 themeOf TRAF6,recruited
R9309 T14130 T14129 themeOf p62,binding
R9310 T14131 T14127 causeOf sequestosome 1,via
R9311 T14132 T14133 causeOf CYLD,mediated