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{"project":"GO-BP","denotations":[{"id":"T10658","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0061667"},{"id":"T10657","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0061666"},{"id":"T10656","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0061665"},{"id":"T10655","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0061664"},{"id":"T10654","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0061663"},{"id":"T10653","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0061662"},{"id":"T10652","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0061661"},{"id":"T10651","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0061660"},{"id":"T10650","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0061659"},{"id":"T10649","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0061630"},{"id":"T10648","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0061658"},{"id":"T10647","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0061657"},{"id":"T10646","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0061656"},{"id":"T10645","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0061655"},{"id":"T10644","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0061654"},{"id":"T10643","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0061653"},{"id":"T10642","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0061652"},{"id":"T10641","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0061651"},{"id":"T10640","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0061650"},{"id":"T10639","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0061631"},{"id":"T10638","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0019787"},{"id":"T10637","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0019787"},{"id":"T10636","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0004842"},{"id":"T10635","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0004842"},{"id":"T10631","span":{"begin":764,"end":774},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T10630","span":{"begin":399,"end":409},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T10628","span":{"begin":758,"end":774},"obj":"http://purl.obolibrary.org/obo/GO_0038061"},{"id":"T10627","span":{"begin":393,"end":409},"obj":"http://purl.obolibrary.org/obo/GO_0038061"},{"id":"T10626","span":{"begin":897,"end":915},"obj":"http://purl.obolibrary.org/obo/GO_0007252"},{"id":"T10625","span":{"begin":341,"end":354},"obj":"http://purl.obolibrary.org/obo/GO_0007252"},{"id":"T10624","span":{"begin":897,"end":915},"obj":"http://purl.obolibrary.org/obo/GO_0032088"},{"id":"T10623","span":{"begin":341,"end":354},"obj":"http://purl.obolibrary.org/obo/GO_0032088"},{"id":"T10621","span":{"begin":101,"end":116},"obj":"http://purl.obolibrary.org/obo/GO_0010467"}],"text":"A20 (also known as TNFAIP3) is a ubiquitin-editing protein that negatively regulates NF-κB-dependent gene expression in response to different immune-activating stimuli, including TNF, IL-1 and antigens, and the triggering of TLRs and the nucleotide-binding oligomerisation domain-containing 2 receptor (reviewed in [37]). A20 is believed to inhibit NF-κB function by deubiquitinating specific NF-κB signalling molecules, such as RIP1, RIP2, TRAF6 and MALT1, which disrupts specific protein-protein interactions [38-41] (Figure 1). Recently, the disruption of interactions between E2 ubiquitin conjugating enzymes (Ubc13 and Ubc5hc) and E3 ubiquitin ligases (TRAF6, TRAF2 and cIAP1/2) were described as another important mechanism used by A20 to downregulate NF-κB signalling [42]. The association of A20 with its targets requires specific ubiquitin-binding adaptor proteins, including A20-binding inhibitor of NF-κB (ABIN) 1 and Tax1-binding protein 1 [43-46]."}

{"project":"GO-MF","denotations":[{"id":"T10720","span":{"begin":934,"end":951},"obj":"http://purl.obolibrary.org/obo/GO_0008157"},{"id":"T10719","span":{"begin":934,"end":949},"obj":"http://purl.obolibrary.org/obo/GO_0005515"},{"id":"T10718","span":{"begin":839,"end":856},"obj":"http://purl.obolibrary.org/obo/GO_0043130"},{"id":"T10717","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0061667"},{"id":"T10716","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0061666"},{"id":"T10715","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0061665"},{"id":"T10714","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0061664"},{"id":"T10713","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0061663"},{"id":"T10712","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0061662"},{"id":"T10711","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0061661"},{"id":"T10710","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0061660"},{"id":"T10709","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0061659"},{"id":"T10708","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0061630"},{"id":"T10707","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0061658"},{"id":"T10706","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0061657"},{"id":"T10705","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0061656"},{"id":"T10704","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0061655"},{"id":"T10703","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0061654"},{"id":"T10702","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0061653"},{"id":"T10701","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0061652"},{"id":"T10700","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0061651"},{"id":"T10699","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0061650"},{"id":"T10698","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0061631"},{"id":"T10697","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0019787"},{"id":"T10696","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0019787"},{"id":"T10695","span":{"begin":636,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0004842"},{"id":"T10694","span":{"begin":580,"end":582},"obj":"http://purl.obolibrary.org/obo/GO_0004842"},{"id":"T10693","span":{"begin":934,"end":941},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T10692","span":{"begin":889,"end":896},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T10691","span":{"begin":849,"end":856},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T10690","span":{"begin":249,"end":256},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T10689","span":{"begin":238,"end":256},"obj":"http://purl.obolibrary.org/obo/GO_0000166"},{"id":"T10687","span":{"begin":184,"end":188},"obj":"http://purl.obolibrary.org/obo/GO_0005149"},{"id":"T10686","span":{"begin":839,"end":848},"obj":"http://purl.obolibrary.org/obo/GO_0031386"},{"id":"T10685","span":{"begin":639,"end":648},"obj":"http://purl.obolibrary.org/obo/GO_0031386"},{"id":"T10684","span":{"begin":583,"end":592},"obj":"http://purl.obolibrary.org/obo/GO_0031386"},{"id":"T10683","span":{"begin":33,"end":42},"obj":"http://purl.obolibrary.org/obo/GO_0031386"}],"text":"A20 (also known as TNFAIP3) is a ubiquitin-editing protein that negatively regulates NF-κB-dependent gene expression in response to different immune-activating stimuli, including TNF, IL-1 and antigens, and the triggering of TLRs and the nucleotide-binding oligomerisation domain-containing 2 receptor (reviewed in [37]). A20 is believed to inhibit NF-κB function by deubiquitinating specific NF-κB signalling molecules, such as RIP1, RIP2, TRAF6 and MALT1, which disrupts specific protein-protein interactions [38-41] (Figure 1). Recently, the disruption of interactions between E2 ubiquitin conjugating enzymes (Ubc13 and Ubc5hc) and E3 ubiquitin ligases (TRAF6, TRAF2 and cIAP1/2) were described as another important mechanism used by A20 to downregulate NF-κB signalling [42]. The association of A20 with its targets requires specific ubiquitin-binding adaptor proteins, including A20-binding inhibitor of NF-κB (ABIN) 1 and Tax1-binding protein 1 [43-46]."}

{"project":"sentences","denotations":[{"id":"T9646","span":{"begin":781,"end":960},"obj":"Sentence"},{"id":"T9645","span":{"begin":531,"end":780},"obj":"Sentence"},{"id":"T9644","span":{"begin":322,"end":530},"obj":"Sentence"},{"id":"T9643","span":{"begin":0,"end":321},"obj":"Sentence"},{"id":"T100","span":{"begin":0,"end":321},"obj":"Sentence"},{"id":"T101","span":{"begin":322,"end":530},"obj":"Sentence"},{"id":"T102","span":{"begin":531,"end":780},"obj":"Sentence"},{"id":"T103","span":{"begin":781,"end":960},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"A20 (also known as TNFAIP3) is a ubiquitin-editing protein that negatively regulates NF-κB-dependent gene expression in response to different immune-activating stimuli, including TNF, IL-1 and antigens, and the triggering of TLRs and the nucleotide-binding oligomerisation domain-containing 2 receptor (reviewed in [37]). A20 is believed to inhibit NF-κB function by deubiquitinating specific NF-κB signalling molecules, such as RIP1, RIP2, TRAF6 and MALT1, which disrupts specific protein-protein interactions [38-41] (Figure 1). Recently, the disruption of interactions between E2 ubiquitin conjugating enzymes (Ubc13 and Ubc5hc) and E3 ubiquitin ligases (TRAF6, TRAF2 and cIAP1/2) were described as another important mechanism used by A20 to downregulate NF-κB signalling [42]. The association of A20 with its targets requires specific ubiquitin-binding adaptor proteins, including A20-binding inhibitor of NF-κB (ABIN) 1 and Tax1-binding protein 1 [43-46]."}

{"project":"simple1","denotations":[{"id":"T10755","span":{"begin":929,"end":951},"obj":"Protein"},{"id":"T10754","span":{"begin":885,"end":924},"obj":"Protein"},{"id":"T10753","span":{"begin":800,"end":803},"obj":"Protein"},{"id":"T10752","span":{"begin":738,"end":741},"obj":"Protein"},{"id":"T10751","span":{"begin":681,"end":682},"obj":"Protein"},{"id":"T10750","span":{"begin":675,"end":680},"obj":"Protein"},{"id":"T10749","span":{"begin":665,"end":670},"obj":"Protein"},{"id":"T10748","span":{"begin":658,"end":663},"obj":"Protein"},{"id":"T10747","span":{"begin":624,"end":630},"obj":"Protein"},{"id":"T10746","span":{"begin":614,"end":619},"obj":"Protein"},{"id":"T10745","span":{"begin":451,"end":456},"obj":"Protein"},{"id":"T10744","span":{"begin":441,"end":446},"obj":"Protein"},{"id":"T10743","span":{"begin":435,"end":439},"obj":"Protein"},{"id":"T10742","span":{"begin":429,"end":433},"obj":"Protein"},{"id":"T10741","span":{"begin":322,"end":325},"obj":"Protein"},{"id":"T10740","span":{"begin":179,"end":182},"obj":"Protein"},{"id":"T10739","span":{"begin":85,"end":90},"obj":"Protein"},{"id":"T10738","span":{"begin":33,"end":58},"obj":"Protein"},{"id":"T10737","span":{"begin":19,"end":26},"obj":"Protein"},{"id":"T10736","span":{"begin":0,"end":3},"obj":"Protein"}],"text":"A20 (also known as TNFAIP3) is a ubiquitin-editing protein that negatively regulates NF-κB-dependent gene expression in response to different immune-activating stimuli, including TNF, IL-1 and antigens, and the triggering of TLRs and the nucleotide-binding oligomerisation domain-containing 2 receptor (reviewed in [37]). A20 is believed to inhibit NF-κB function by deubiquitinating specific NF-κB signalling molecules, such as RIP1, RIP2, TRAF6 and MALT1, which disrupts specific protein-protein interactions [38-41] (Figure 1). Recently, the disruption of interactions between E2 ubiquitin conjugating enzymes (Ubc13 and Ubc5hc) and E3 ubiquitin ligases (TRAF6, TRAF2 and cIAP1/2) were described as another important mechanism used by A20 to downregulate NF-κB signalling [42]. The association of A20 with its targets requires specific ubiquitin-binding adaptor proteins, including A20-binding inhibitor of NF-κB (ABIN) 1 and Tax1-binding protein 1 [43-46]."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T12249","span":{"begin":821,"end":829},"obj":"Positive_regulation"},{"id":"T12248","span":{"begin":813,"end":820},"obj":"Regulation"},{"id":"T12247","span":{"begin":785,"end":796},"obj":"Binding"},{"id":"T12246","span":{"begin":545,"end":555},"obj":"Negative_regulation"},{"id":"T12245","span":{"begin":559,"end":571},"obj":"Binding"},{"id":"T12244","span":{"begin":498,"end":510},"obj":"Binding"},{"id":"T12243","span":{"begin":75,"end":84},"obj":"Regulation"},{"id":"T12201","span":{"begin":929,"end":951},"obj":"Protein"},{"id":"T12200","span":{"begin":885,"end":924},"obj":"Protein"},{"id":"T12199","span":{"begin":800,"end":803},"obj":"Protein"},{"id":"T12198","span":{"begin":738,"end":741},"obj":"Protein"},{"id":"T12197","span":{"begin":681,"end":682},"obj":"Protein"},{"id":"T12196","span":{"begin":675,"end":680},"obj":"Protein"},{"id":"T12195","span":{"begin":665,"end":670},"obj":"Protein"},{"id":"T12194","span":{"begin":658,"end":663},"obj":"Protein"},{"id":"T12193","span":{"begin":624,"end":630},"obj":"Protein"},{"id":"T12192","span":{"begin":614,"end":619},"obj":"Protein"},{"id":"T12191","span":{"begin":435,"end":439},"obj":"Protein"},{"id":"T12190","span":{"begin":429,"end":433},"obj":"Protein"},{"id":"T12189","span":{"begin":322,"end":325},"obj":"Protein"},{"id":"T12188","span":{"begin":451,"end":456},"obj":"Protein"},{"id":"T12187","span":{"begin":441,"end":446},"obj":"Protein"},{"id":"T12186","span":{"begin":179,"end":182},"obj":"Protein"},{"id":"T12185","span":{"begin":85,"end":90},"obj":"Protein"},{"id":"T12184","span":{"begin":33,"end":58},"obj":"Protein"},{"id":"T12183","span":{"begin":19,"end":26},"obj":"Protein"},{"id":"T12182","span":{"begin":0,"end":3},"obj":"Protein"}],"relations":[{"id":"R8223","pred":"themeOf","subj":"T12182","obj":"T12243"},{"id":"R8226","pred":"themeOf","subj":"T12191","obj":"T12244"},{"id":"R8227","pred":"themeOf","subj":"T12192","obj":"T12246"},{"id":"R8228","pred":"themeOf","subj":"T12192","obj":"T12245"},{"id":"R8229","pred":"themeOf","subj":"T12193","obj":"T12245"},{"id":"R8230","pred":"themeOf","subj":"T12194","obj":"T12245"},{"id":"R8231","pred":"themeOf","subj":"T12195","obj":"T12245"},{"id":"R8232","pred":"themeOf","subj":"T12196","obj":"T12245"},{"id":"R8233","pred":"themeOf","subj":"T12197","obj":"T12245"},{"id":"R8235","pred":"themeOf","subj":"T12199","obj":"T12247"},{"id":"R8236","pred":"themeOf","subj":"T12200","obj":"T12249"},{"id":"R8272","pred":"themeOf","subj":"T12247","obj":"T12248"}],"text":"A20 (also known as TNFAIP3) is a ubiquitin-editing protein that negatively regulates NF-κB-dependent gene expression in response to different immune-activating stimuli, including TNF, IL-1 and antigens, and the triggering of TLRs and the nucleotide-binding oligomerisation domain-containing 2 receptor (reviewed in [37]). A20 is believed to inhibit NF-κB function by deubiquitinating specific NF-κB signalling molecules, such as RIP1, RIP2, TRAF6 and MALT1, which disrupts specific protein-protein interactions [38-41] (Figure 1). Recently, the disruption of interactions between E2 ubiquitin conjugating enzymes (Ubc13 and Ubc5hc) and E3 ubiquitin ligases (TRAF6, TRAF2 and cIAP1/2) were described as another important mechanism used by A20 to downregulate NF-κB signalling [42]. The association of A20 with its targets requires specific ubiquitin-binding adaptor proteins, including A20-binding inhibitor of NF-κB (ABIN) 1 and Tax1-binding protein 1 [43-46]."}

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