PMC:3218875 / 17060-17939 JSONTXT

{"project":"testone","denotations":[{"id":"T8347","span":{"begin":402,"end":413},"obj":"Protein_catabolism"},{"id":"T8346","span":{"begin":368,"end":376},"obj":"Positive_regulation"},{"id":"T8345","span":{"begin":273,"end":283},"obj":"Gene_expression"},{"id":"T8344","span":{"begin":242,"end":251},"obj":"Negative_regulation"},{"id":"T8343","span":{"begin":721,"end":725},"obj":"Protein"},{"id":"T8342","span":{"begin":620,"end":623},"obj":"Protein"},{"id":"T8341","span":{"begin":600,"end":604},"obj":"Protein"},{"id":"T8340","span":{"begin":536,"end":541},"obj":"Protein"},{"id":"T8339","span":{"begin":420,"end":424},"obj":"Protein"},{"id":"T8338","span":{"begin":397,"end":401},"obj":"Protein"},{"id":"T8337","span":{"begin":377,"end":381},"obj":"Protein"},{"id":"T8336","span":{"begin":293,"end":297},"obj":"Protein"},{"id":"T8335","span":{"begin":237,"end":241},"obj":"Protein"},{"id":"T8334","span":{"begin":9,"end":13},"obj":"Protein"}],"relations":[{"id":"R5567","pred":"themeOf","subj":"T8335","obj":"T8344"},{"id":"R5568","pred":"themeOf","subj":"T8336","obj":"T8345"},{"id":"R5569","pred":"themeOf","subj":"T8338","obj":"T8347"},{"id":"R5570","pred":"themeOf","subj":"T8347","obj":"T8346"}],"text":"Although IKK1 is a critical component of the non-canonical NF-κB pathway, it should be mentioned that this kinase also plays a prominent role in the negative regulation of both canonical and noncanonical NF-κB pathways. Macrophages from IKK1-deficient mice or knockin mice expressing inactive IKK1 show increased production of proinflammatory cytokines as a result of enhanced IKK2 activation and IκBα degradation [34]. IKK1 has also been shown to inhibit nuclear NF-κB and to downregulate proinflammatory signalling by phosphorylating STAT1 [35]. Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback regulation of the noncanonical NF-κB pathway [36], supporting the idea that IKK1 plays important roles in terminating both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA."}

{"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T9023","span":{"begin":303,"end":312},"obj":"VBD"},{"id":"T9022","span":{"begin":298,"end":302},"obj":"NN"},{"id":"T9021","span":{"begin":293,"end":297},"obj":"NNP"},{"id":"T9020","span":{"begin":284,"end":292},"obj":"JJ"},{"id":"T9019","span":{"begin":273,"end":283},"obj":"VBG"},{"id":"T9018","span":{"begin":268,"end":272},"obj":"NNS"},{"id":"T9017","span":{"begin":260,"end":267},"obj":"VB"},{"id":"T9016","span":{"begin":257,"end":259},"obj":"CC"},{"id":"T9015","span":{"begin":252,"end":256},"obj":"NNS"},{"id":"T9014","span":{"begin":237,"end":251},"obj":"JJ"},{"id":"T9013","span":{"begin":232,"end":236},"obj":"IN"},{"id":"T9012","span":{"begin":220,"end":231},"obj":"NNS"},{"id":"T9011","span":{"begin":218,"end":219},"obj":"."},{"id":"T9010","span":{"begin":210,"end":218},"obj":"NNS"},{"id":"T9009","span":{"begin":204,"end":209},"obj":"NN"},{"id":"T9008","span":{"begin":191,"end":203},"obj":"JJ"},{"id":"T9007","span":{"begin":187,"end":190},"obj":"CC"},{"id":"T9006","span":{"begin":177,"end":186},"obj":"JJ"},{"id":"T9005","span":{"begin":172,"end":176},"obj":"DT"},{"id":"T9004","span":{"begin":169,"end":171},"obj":"IN"},{"id":"T9003","span":{"begin":158,"end":168},"obj":"NN"},{"id":"T9002","span":{"begin":149,"end":157},"obj":"JJ"},{"id":"T9001","span":{"begin":145,"end":148},"obj":"DT"},{"id":"T9000","span":{"begin":142,"end":144},"obj":"IN"},{"id":"T8999","span":{"begin":137,"end":141},"obj":"NN"},{"id":"T8998","span":{"begin":127,"end":136},"obj":"JJ"},{"id":"T8997","span":{"begin":125,"end":126},"obj":"DT"},{"id":"T8996","span":{"begin":119,"end":124},"obj":"VBZ"},{"id":"T8995","span":{"begin":114,"end":118},"obj":"RB"},{"id":"T8994","span":{"begin":107,"end":113},"obj":"NN"},{"id":"T8993","span":{"begin":102,"end":106},"obj":"DT"},{"id":"T8992","span":{"begin":97,"end":101},"obj":"IN"},{"id":"T8991","span":{"begin":87,"end":96},"obj":"VBN"},{"id":"T8990","span":{"begin":84,"end":86},"obj":"VB"},{"id":"T8989","span":{"begin":77,"end":83},"obj":"MD"},{"id":"T8988","span":{"begin":74,"end":76},"obj":"PRP"},{"id":"T8987","span":{"begin":72,"end":73},"obj":","},{"id":"T8986","span":{"begin":65,"end":72},"obj":"NN"},{"id":"T8985","span":{"begin":59,"end":64},"obj":"NN"},{"id":"T8984","span":{"begin":45,"end":58},"obj":"JJ"},{"id":"T8983","span":{"begin":41,"end":44},"obj":"DT"},{"id":"T8982","span":{"begin":38,"end":40},"obj":"IN"},{"id":"T8981","span":{"begin":28,"end":37},"obj":"NN"},{"id":"T8980","span":{"begin":19,"end":27},"obj":"JJ"},{"id":"T8979","span":{"begin":17,"end":18},"obj":"DT"},{"id":"T8978","span":{"begin":14,"end":16},"obj":"VBZ"},{"id":"T8977","span":{"begin":9,"end":13},"obj":"NNP"},{"id":"T9112","span":{"begin":878,"end":879},"obj":"."},{"id":"T9111","span":{"begin":876,"end":878},"obj":"NNP"},{"id":"T9110","span":{"begin":871,"end":875},"obj":"IN"},{"id":"T9109","span":{"begin":862,"end":870},"obj":"NNS"},{"id":"T9108","span":{"begin":849,"end":861},"obj":"JJ"},{"id":"T9107","span":{"begin":841,"end":848},"obj":"JJ"},{"id":"T9106","span":{"begin":837,"end":840},"obj":"IN"},{"id":"T9105","span":{"begin":824,"end":836},"obj":"NNS"},{"id":"T9104","span":{"begin":815,"end":823},"obj":"JJ"},{"id":"T9103","span":{"begin":810,"end":814},"obj":"IN"},{"id":"T9102","span":{"begin":801,"end":809},"obj":"NNS"},{"id":"T9101","span":{"begin":795,"end":800},"obj":"NN"},{"id":"T9100","span":{"begin":782,"end":794},"obj":"JJ"},{"id":"T9099","span":{"begin":778,"end":781},"obj":"CC"},{"id":"T9098","span":{"begin":768,"end":777},"obj":"JJ"},{"id":"T9097","span":{"begin":763,"end":767},"obj":"DT"},{"id":"T9096","span":{"begin":751,"end":762},"obj":"VBG"},{"id":"T9095","span":{"begin":748,"end":750},"obj":"IN"},{"id":"T9094","span":{"begin":742,"end":747},"obj":"NNS"},{"id":"T9093","span":{"begin":732,"end":741},"obj":"JJ"},{"id":"T9092","span":{"begin":726,"end":731},"obj":"VBZ"},{"id":"T9091","span":{"begin":721,"end":725},"obj":"NNP"},{"id":"T9090","span":{"begin":716,"end":720},"obj":"WDT"},{"id":"T9089","span":{"begin":711,"end":715},"obj":"NN"},{"id":"T9088","span":{"begin":707,"end":710},"obj":"DT"},{"id":"T9087","span":{"begin":696,"end":706},"obj":"VBG"},{"id":"T9086","span":{"begin":694,"end":695},"obj":","},{"id":"T9085","span":{"begin":693,"end":694},"obj":"NNP"},{"id":"T9084","span":{"begin":691,"end":693},"obj":"CD"},{"id":"T9083","span":{"begin":690,"end":691},"obj":"NNP"},{"id":"T9082","span":{"begin":682,"end":689},"obj":"NN"},{"id":"T9081","span":{"begin":676,"end":681},"obj":"NN"},{"id":"T9080","span":{"begin":663,"end":675},"obj":"JJ"},{"id":"T9079","span":{"begin":659,"end":662},"obj":"DT"},{"id":"T9078","span":{"begin":656,"end":658},"obj":"IN"},{"id":"T9077","span":{"begin":645,"end":655},"obj":"NN"},{"id":"T9076","span":{"begin":636,"end":644},"obj":"NN"},{"id":"T9075","span":{"begin":627,"end":635},"obj":"JJ"},{"id":"T9074","span":{"begin":624,"end":626},"obj":"IN"},{"id":"T9073","span":{"begin":620,"end":623},"obj":"NNP"},{"id":"T9072","span":{"begin":605,"end":619},"obj":"NNS"},{"id":"T9071","span":{"begin":600,"end":604},"obj":"CD"},{"id":"T9070","span":{"begin":595,"end":599},"obj":"IN"},{"id":"T9069","span":{"begin":582,"end":594},"obj":"VBN"},{"id":"T9068","span":{"begin":578,"end":581},"obj":"VBZ"},{"id":"T9067","span":{"begin":572,"end":577},"obj":"NN"},{"id":"T9066","span":{"begin":565,"end":571},"obj":"JJ"},{"id":"T9065","span":{"begin":563,"end":564},"obj":"DT"},{"id":"T9064","span":{"begin":561,"end":562},"obj":","},{"id":"T9063","span":{"begin":548,"end":561},"obj":"RB"},{"id":"T9062","span":{"begin":546,"end":547},"obj":"."},{"id":"T9061","span":{"begin":545,"end":546},"obj":"NNP"},{"id":"T9060","span":{"begin":543,"end":545},"obj":"CD"},{"id":"T9059","span":{"begin":542,"end":543},"obj":"NNP"},{"id":"T9058","span":{"begin":536,"end":541},"obj":"NNP"},{"id":"T9057","span":{"begin":520,"end":535},"obj":"VBG"},{"id":"T9056","span":{"begin":517,"end":519},"obj":"IN"},{"id":"T9055","span":{"begin":506,"end":516},"obj":"NN"},{"id":"T9054","span":{"begin":490,"end":505},"obj":"JJ"},{"id":"T9053","span":{"begin":477,"end":489},"obj":"VB"},{"id":"T9052","span":{"begin":474,"end":476},"obj":"TO"},{"id":"T9051","span":{"begin":470,"end":473},"obj":"CC"},{"id":"T9050","span":{"begin":464,"end":469},"obj":"NN"},{"id":"T9049","span":{"begin":456,"end":463},"obj":"JJ"},{"id":"T9048","span":{"begin":448,"end":455},"obj":"VB"},{"id":"T9047","span":{"begin":445,"end":447},"obj":"TO"},{"id":"T9046","span":{"begin":439,"end":444},"obj":"VBN"},{"id":"T9045","span":{"begin":434,"end":438},"obj":"VBN"},{"id":"T9044","span":{"begin":429,"end":433},"obj":"RB"},{"id":"T9043","span":{"begin":425,"end":428},"obj":"VBZ"},{"id":"T9042","span":{"begin":420,"end":424},"obj":"CD"},{"id":"T9041","span":{"begin":418,"end":419},"obj":"."},{"id":"T9040","span":{"begin":417,"end":418},"obj":"NNP"},{"id":"T9039","span":{"begin":415,"end":417},"obj":"CD"},{"id":"T9038","span":{"begin":414,"end":415},"obj":"NNP"},{"id":"T9037","span":{"begin":402,"end":413},"obj":"NN"},{"id":"T9036","span":{"begin":397,"end":401},"obj":"NNP"},{"id":"T9035","span":{"begin":393,"end":396},"obj":"CC"},{"id":"T9034","span":{"begin":382,"end":392},"obj":"NN"},{"id":"T9033","span":{"begin":377,"end":381},"obj":"NNP"},{"id":"T9032","span":{"begin":368,"end":376},"obj":"JJ"},{"id":"T9031","span":{"begin":365,"end":367},"obj":"IN"},{"id":"T9030","span":{"begin":358,"end":364},"obj":"NN"},{"id":"T9029","span":{"begin":356,"end":357},"obj":"DT"},{"id":"T9028","span":{"begin":353,"end":355},"obj":"IN"},{"id":"T9027","span":{"begin":343,"end":352},"obj":"NNS"},{"id":"T9026","span":{"begin":327,"end":342},"obj":"JJ"},{"id":"T9025","span":{"begin":324,"end":326},"obj":"IN"},{"id":"T9024","span":{"begin":313,"end":323},"obj":"NN"}],"relations":[{"id":"R6111","pred":"nsubj","subj":"T8977","obj":"T8978"},{"id":"R6112","pred":"advcl","subj":"T8978","obj":"T8991"},{"id":"R6113","pred":"det","subj":"T8979","obj":"T8981"},{"id":"R6114","pred":"amod","subj":"T8980","obj":"T8981"},{"id":"R6115","pred":"attr","subj":"T8981","obj":"T8978"},{"id":"R6116","pred":"prep","subj":"T8982","obj":"T8981"},{"id":"R6117","pred":"det","subj":"T8983","obj":"T8986"},{"id":"R6118","pred":"amod","subj":"T8984","obj":"T8986"},{"id":"R6119","pred":"compound","subj":"T8985","obj":"T8986"},{"id":"R6120","pred":"pobj","subj":"T8986","obj":"T8982"},{"id":"R6121","pred":"punct","subj":"T8987","obj":"T8991"},{"id":"R6122","pred":"nsubjpass","subj":"T8988","obj":"T8991"},{"id":"R6123","pred":"aux","subj":"T8989","obj":"T8991"},{"id":"R6124","pred":"auxpass","subj":"T8990","obj":"T8991"},{"id":"R6126","pred":"mark","subj":"T8992","obj":"T8996"},{"id":"R6127","pred":"det","subj":"T8993","obj":"T8994"},{"id":"R6128","pred":"nsubj","subj":"T8994","obj":"T8996"},{"id":"R6129","pred":"advmod","subj":"T8995","obj":"T8996"},{"id":"R6130","pred":"ccomp","subj":"T8996","obj":"T8991"},{"id":"R6131","pred":"det","subj":"T8997","obj":"T8999"},{"id":"R6132","pred":"amod","subj":"T8998","obj":"T8999"},{"id":"R6133","pred":"dobj","subj":"T8999","obj":"T8996"},{"id":"R6134","pred":"prep","subj":"T9000","obj":"T8999"},{"id":"R6135","pred":"det","subj":"T9001","obj":"T9003"},{"id":"R6136","pred":"amod","subj":"T9002","obj":"T9003"},{"id":"R6137","pred":"pobj","subj":"T9003","obj":"T9000"},{"id":"R6138","pred":"prep","subj":"T9004","obj":"T9003"},{"id":"R6139","pred":"preconj","subj":"T9005","obj":"T9006"},{"id":"R6140","pred":"amod","subj":"T9006","obj":"T9010"},{"id":"R6141","pred":"cc","subj":"T9007","obj":"T9006"},{"id":"R6142","pred":"conj","subj":"T9008","obj":"T9006"},{"id":"R6143","pred":"compound","subj":"T9009","obj":"T9010"},{"id":"R6144","pred":"pobj","subj":"T9010","obj":"T9004"},{"id":"R6146","pred":"nsubj","subj":"T9012","obj":"T9023"},{"id":"R6147","pred":"prep","subj":"T9013","obj":"T9012"},{"id":"R6148","pred":"amod","subj":"T9014","obj":"T9015"},{"id":"R6149","pred":"pobj","subj":"T9015","obj":"T9013"},{"id":"R6150","pred":"cc","subj":"T9016","obj":"T9015"},{"id":"R6151","pred":"compound","subj":"T9017","obj":"T9018"},{"id":"R6152","pred":"conj","subj":"T9018","obj":"T9015"},{"id":"R6153","pred":"acl","subj":"T9019","obj":"T9012"},{"id":"R6154","pred":"amod","subj":"T9020","obj":"T9022"},{"id":"R6155","pred":"compound","subj":"T9021","obj":"T9022"},{"id":"R6156","pred":"dobj","subj":"T9022","obj":"T9019"},{"id":"R6157","pred":"ROOT","subj":"T9023","obj":"T9023"},{"id":"R6158","pred":"dobj","subj":"T9024","obj":"T9023"},{"id":"R6159","pred":"prep","subj":"T9025","obj":"T9024"},{"id":"R6160","pred":"amod","subj":"T9026","obj":"T9027"},{"id":"R6161","pred":"pobj","subj":"T9027","obj":"T9025"},{"id":"R6162","pred":"prep","subj":"T9028","obj":"T9023"},{"id":"R6163","pred":"det","subj":"T9029","obj":"T9030"},{"id":"R6164","pred":"pobj","subj":"T9030","obj":"T9028"},{"id":"R6165","pred":"prep","subj":"T9031","obj":"T9030"},{"id":"R6166","pred":"amod","subj":"T9032","obj":"T9034"},{"id":"R6167","pred":"compound","subj":"T9033","obj":"T9034"},{"id":"R6168","pred":"pobj","subj":"T9034","obj":"T9031"},{"id":"R6169","pred":"cc","subj":"T9035","obj":"T9034"},{"id":"R6170","pred":"compound","subj":"T9036","obj":"T9037"},{"id":"R6171","pred":"conj","subj":"T9037","obj":"T9034"},{"id":"R6172","pred":"nmod","subj":"T9038","obj":"T9040"},{"id":"R6173","pred":"nummod","subj":"T9039","obj":"T9040"},{"id":"R6174","pred":"appos","subj":"T9040","obj":"T9037"},{"id":"R6175","pred":"punct","subj":"T9041","obj":"T9023"},{"id":"R6176","pred":"nsubjpass","subj":"T9042","obj":"T9046"},{"id":"R6177","pred":"aux","subj":"T9043","obj":"T9046"},{"id":"R6178","pred":"advmod","subj":"T9044","obj":"T9046"},{"id":"R6179","pred":"auxpass","subj":"T9045","obj":"T9046"},{"id":"R6180","pred":"ROOT","subj":"T9046","obj":"T9046"},{"id":"R6181","pred":"aux","subj":"T9047","obj":"T9048"},{"id":"R6182","pred":"advcl","subj":"T9048","obj":"T9046"},{"id":"R6183","pred":"amod","subj":"T9049","obj":"T9050"},{"id":"R6184","pred":"dobj","subj":"T9050","obj":"T9048"},{"id":"R6185","pred":"cc","subj":"T9051","obj":"T9048"},{"id":"R6186","pred":"aux","subj":"T9052","obj":"T9053"},{"id":"R6187","pred":"conj","subj":"T9053","obj":"T9048"},{"id":"R6188","pred":"compound","subj":"T9054","obj":"T9055"},{"id":"R6189","pred":"dobj","subj":"T9055","obj":"T9053"},{"id":"R6190","pred":"prep","subj":"T9056","obj":"T9053"},{"id":"R6191","pred":"pcomp","subj":"T9057","obj":"T9056"},{"id":"R6192","pred":"compound","subj":"T9058","obj":"T9059"},{"id":"R6193","pred":"dobj","subj":"T9059","obj":"T9057"},{"id":"R6194","pred":"nummod","subj":"T9060","obj":"T9061"},{"id":"R6195","pred":"appos","subj":"T9061","obj":"T9059"},{"id":"R6196","pred":"punct","subj":"T9062","obj":"T9046"},{"id":"R6197","pred":"advmod","subj":"T9063","obj":"T9069"},{"id":"R6198","pred":"punct","subj":"T9064","obj":"T9069"},{"id":"R6199","pred":"det","subj":"T9065","obj":"T9067"},{"id":"R6200","pred":"amod","subj":"T9066","obj":"T9067"},{"id":"R6201","pred":"nsubj","subj":"T9067","obj":"T9069"},{"id":"R6202","pred":"aux","subj":"T9068","obj":"T9069"},{"id":"R6203","pred":"ROOT","subj":"T9069","obj":"T9069"},{"id":"R6204","pred":"dobj","subj":"T9070","obj":"T9069"},{"id":"R6205","pred":"nummod","subj":"T9071","obj":"T9072"},{"id":"R6206","pred":"nsubj","subj":"T9072","obj":"T9070"},{"id":"R6207","pred":"appos","subj":"T9073","obj":"T9072"},{"id":"R6208","pred":"prep","subj":"T9074","obj":"T9073"},{"id":"R6209","pred":"amod","subj":"T9075","obj":"T9077"},{"id":"R6210","pred":"compound","subj":"T9076","obj":"T9077"},{"id":"R6211","pred":"pobj","subj":"T9077","obj":"T9074"},{"id":"R6212","pred":"prep","subj":"T9078","obj":"T9077"},{"id":"R6213","pred":"det","subj":"T9079","obj":"T9082"},{"id":"R6214","pred":"amod","subj":"T9080","obj":"T9082"},{"id":"R6215","pred":"compound","subj":"T9081","obj":"T9082"},{"id":"R6216","pred":"pobj","subj":"T9082","obj":"T9078"},{"id":"R6217","pred":"nmod","subj":"T9083","obj":"T9085"},{"id":"R6218","pred":"nummod","subj":"T9084","obj":"T9085"},{"id":"R6219","pred":"appos","subj":"T9085","obj":"T9082"},{"id":"R6220","pred":"punct","subj":"T9086","obj":"T9072"},{"id":"R6221","pred":"acl","subj":"T9087","obj":"T9072"},{"id":"R6222","pred":"det","subj":"T9088","obj":"T9089"},{"id":"R6223","pred":"dobj","subj":"T9089","obj":"T9087"},{"id":"R6224","pred":"mark","subj":"T9090","obj":"T9092"},{"id":"R6225","pred":"nsubj","subj":"T9091","obj":"T9092"},{"id":"R6226","pred":"acl","subj":"T9092","obj":"T9089"},{"id":"R6227","pred":"amod","subj":"T9093","obj":"T9094"},{"id":"R6228","pred":"dobj","subj":"T9094","obj":"T9092"},{"id":"R6229","pred":"prep","subj":"T9095","obj":"T9092"},{"id":"R6230","pred":"pcomp","subj":"T9096","obj":"T9095"},{"id":"R6231","pred":"preconj","subj":"T9097","obj":"T9098"},{"id":"R6232","pred":"amod","subj":"T9098","obj":"T9102"},{"id":"R6233","pred":"cc","subj":"T9099","obj":"T9098"},{"id":"R6234","pred":"conj","subj":"T9100","obj":"T9098"},{"id":"R6235","pred":"compound","subj":"T9101","obj":"T9102"},{"id":"R6236","pred":"dobj","subj":"T9102","obj":"T9096"},{"id":"R6237","pred":"prep","subj":"T9103","obj":"T9102"},{"id":"R6238","pred":"amod","subj":"T9104","obj":"T9105"},{"id":"R6239","pred":"pobj","subj":"T9105","obj":"T9103"},{"id":"R6240","pred":"prep","subj":"T9106","obj":"T9105"},{"id":"R6241","pred":"amod","subj":"T9107","obj":"T9109"},{"id":"R6242","pred":"amod","subj":"T9108","obj":"T9109"},{"id":"R6243","pred":"pobj","subj":"T9109","obj":"T9106"},{"id":"R6244","pred":"prep","subj":"T9110","obj":"T9109"},{"id":"R6245","pred":"pobj","subj":"T9111","obj":"T9110"},{"id":"R6246","pred":"punct","subj":"T9112","obj":"T9069"}],"text":"Although IKK1 is a critical component of the non-canonical NF-κB pathway, it should be mentioned that this kinase also plays a prominent role in the negative regulation of both canonical and noncanonical NF-κB pathways. Macrophages from IKK1-deficient mice or knockin mice expressing inactive IKK1 show increased production of proinflammatory cytokines as a result of enhanced IKK2 activation and IκBα degradation [34]. IKK1 has also been shown to inhibit nuclear NF-κB and to downregulate proinflammatory signalling by phosphorylating STAT1 [35]. Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback regulation of the noncanonical NF-κB pathway [36], supporting the idea that IKK1 plays important roles in terminating both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA."}

{"project":"DLUT931","denotations":[{"id":"T9170","span":{"begin":605,"end":619},"obj":"Phosphorylation"},{"id":"T9169","span":{"begin":520,"end":535},"obj":"Phosphorylation"},{"id":"T9168","span":{"begin":368,"end":376},"obj":"Positive_regulation"},{"id":"T9167","span":{"begin":358,"end":364},"obj":"Positive_regulation"},{"id":"T9166","span":{"begin":402,"end":413},"obj":"Protein_catabolism"},{"id":"T9165","span":{"begin":382,"end":392},"obj":"Positive_regulation"},{"id":"T9164","span":{"begin":284,"end":292},"obj":"Positive_regulation"},{"id":"T9163","span":{"begin":273,"end":283},"obj":"Gene_expression"},{"id":"T9162","span":{"begin":242,"end":251},"obj":"Negative_regulation"},{"id":"T9161","span":{"begin":721,"end":725},"obj":"Protein"},{"id":"T9160","span":{"begin":620,"end":623},"obj":"Protein"},{"id":"T9159","span":{"begin":600,"end":604},"obj":"Protein"},{"id":"T9158","span":{"begin":420,"end":424},"obj":"Protein"},{"id":"T9157","span":{"begin":536,"end":541},"obj":"Protein"},{"id":"T9156","span":{"begin":397,"end":401},"obj":"Protein"},{"id":"T9155","span":{"begin":377,"end":381},"obj":"Protein"},{"id":"T9154","span":{"begin":293,"end":297},"obj":"Protein"},{"id":"T9153","span":{"begin":237,"end":241},"obj":"Protein"},{"id":"T9152","span":{"begin":9,"end":13},"obj":"Protein"}],"relations":[{"id":"R6255","pred":"themeOf","subj":"T9153","obj":"T9162"},{"id":"R6256","pred":"themeOf","subj":"T9154","obj":"T9163"},{"id":"R6257","pred":"themeOf","subj":"T9154","obj":"T9164"},{"id":"R6258","pred":"themeOf","subj":"T9155","obj":"T9165"},{"id":"R6259","pred":"themeOf","subj":"T9156","obj":"T9166"},{"id":"R6260","pred":"themeOf","subj":"T9157","obj":"T9169"},{"id":"R6261","pred":"causeOf","subj":"T9159","obj":"T9170"},{"id":"R6262","pred":"themeOf","subj":"T9160","obj":"T9170"},{"id":"R6263","pred":"themeOf","subj":"T9165","obj":"T9167"},{"id":"R6264","pred":"themeOf","subj":"T9165","obj":"T9168"},{"id":"R6265","pred":"themeOf","subj":"T9166","obj":"T9167"}],"text":"Although IKK1 is a critical component of the non-canonical NF-κB pathway, it should be mentioned that this kinase also plays a prominent role in the negative regulation of both canonical and noncanonical NF-κB pathways. Macrophages from IKK1-deficient mice or knockin mice expressing inactive IKK1 show increased production of proinflammatory cytokines as a result of enhanced IKK2 activation and IκBα degradation [34]. IKK1 has also been shown to inhibit nuclear NF-κB and to downregulate proinflammatory signalling by phosphorylating STAT1 [35]. Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback regulation of the noncanonical NF-κB pathway [36], supporting the idea that IKK1 plays important roles in terminating both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T9127","span":{"begin":620,"end":623},"obj":"http://www.uniprot.org/uniprot/Q99558"},{"id":"T9126","span":{"begin":397,"end":401},"obj":"http://www.uniprot.org/uniprot/P25963"},{"id":"T9125","span":{"begin":377,"end":381},"obj":"http://www.uniprot.org/uniprot/O14920"},{"id":"T9124","span":{"begin":721,"end":725},"obj":"http://www.uniprot.org/uniprot/Q60680-2"},{"id":"T9123","span":{"begin":600,"end":604},"obj":"http://www.uniprot.org/uniprot/Q60680-2"},{"id":"T9122","span":{"begin":420,"end":424},"obj":"http://www.uniprot.org/uniprot/Q60680-2"},{"id":"T9121","span":{"begin":293,"end":297},"obj":"http://www.uniprot.org/uniprot/Q60680-2"},{"id":"T9120","span":{"begin":237,"end":241},"obj":"http://www.uniprot.org/uniprot/Q60680-2"},{"id":"T9119","span":{"begin":9,"end":13},"obj":"http://www.uniprot.org/uniprot/Q60680-2"},{"id":"T9118","span":{"begin":721,"end":725},"obj":"http://www.uniprot.org/uniprot/O15111"},{"id":"T9117","span":{"begin":600,"end":604},"obj":"http://www.uniprot.org/uniprot/O15111"},{"id":"T9116","span":{"begin":420,"end":424},"obj":"http://www.uniprot.org/uniprot/O15111"},{"id":"T9115","span":{"begin":293,"end":297},"obj":"http://www.uniprot.org/uniprot/O15111"},{"id":"T9114","span":{"begin":237,"end":241},"obj":"http://www.uniprot.org/uniprot/O15111"},{"id":"T9113","span":{"begin":9,"end":13},"obj":"http://www.uniprot.org/uniprot/O15111"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Although IKK1 is a critical component of the non-canonical NF-κB pathway, it should be mentioned that this kinase also plays a prominent role in the negative regulation of both canonical and noncanonical NF-κB pathways. Macrophages from IKK1-deficient mice or knockin mice expressing inactive IKK1 show increased production of proinflammatory cytokines as a result of enhanced IKK2 activation and IκBα degradation [34]. IKK1 has also been shown to inhibit nuclear NF-κB and to downregulate proinflammatory signalling by phosphorylating STAT1 [35]. Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback regulation of the noncanonical NF-κB pathway [36], supporting the idea that IKK1 plays important roles in terminating both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T8425","span":{"begin":721,"end":725},"obj":"Protein"},{"id":"T8424","span":{"begin":620,"end":623},"obj":"Protein"},{"id":"T8423","span":{"begin":600,"end":604},"obj":"Protein"},{"id":"T8422","span":{"begin":536,"end":541},"obj":"Protein"},{"id":"T8421","span":{"begin":420,"end":424},"obj":"Protein"},{"id":"T8420","span":{"begin":397,"end":401},"obj":"Protein"},{"id":"T8419","span":{"begin":377,"end":381},"obj":"Protein"},{"id":"T8418","span":{"begin":293,"end":297},"obj":"Protein"},{"id":"T8417","span":{"begin":237,"end":241},"obj":"Protein"},{"id":"T8416","span":{"begin":9,"end":13},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Although IKK1 is a critical component of the non-canonical NF-κB pathway, it should be mentioned that this kinase also plays a prominent role in the negative regulation of both canonical and noncanonical NF-κB pathways. Macrophages from IKK1-deficient mice or knockin mice expressing inactive IKK1 show increased production of proinflammatory cytokines as a result of enhanced IKK2 activation and IκBα degradation [34]. IKK1 has also been shown to inhibit nuclear NF-κB and to downregulate proinflammatory signalling by phosphorylating STAT1 [35]. Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback regulation of the noncanonical NF-κB pathway [36], supporting the idea that IKK1 plays important roles in terminating both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA."}

{"project":"2_test","denotations":[{"id":"21639951-15858576-4289463","span":{"begin":415,"end":417},"obj":"15858576"},{"id":"21639951-17540171-4289464","span":{"begin":543,"end":545},"obj":"17540171"},{"id":"21639951-20501937-4289465","span":{"begin":691,"end":693},"obj":"20501937"}],"text":"Although IKK1 is a critical component of the non-canonical NF-κB pathway, it should be mentioned that this kinase also plays a prominent role in the negative regulation of both canonical and noncanonical NF-κB pathways. Macrophages from IKK1-deficient mice or knockin mice expressing inactive IKK1 show increased production of proinflammatory cytokines as a result of enhanced IKK2 activation and IκBα degradation [34]. IKK1 has also been shown to inhibit nuclear NF-κB and to downregulate proinflammatory signalling by phosphorylating STAT1 [35]. Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback regulation of the noncanonical NF-κB pathway [36], supporting the idea that IKK1 plays important roles in terminating both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA."}

{"project":"pmc-enju-pas","denotations":[{"id":"T8741","span":{"begin":876,"end":878},"obj":"NN"},{"id":"T8740","span":{"begin":871,"end":875},"obj":"IN"},{"id":"T8739","span":{"begin":862,"end":870},"obj":"NN"},{"id":"T8738","span":{"begin":849,"end":861},"obj":"JJ"},{"id":"T8737","span":{"begin":841,"end":848},"obj":"JJ"},{"id":"T8736","span":{"begin":837,"end":840},"obj":"IN"},{"id":"T8735","span":{"begin":824,"end":836},"obj":"NN"},{"id":"T8734","span":{"begin":815,"end":823},"obj":"JJ"},{"id":"T8733","span":{"begin":810,"end":814},"obj":"IN"},{"id":"T8732","span":{"begin":801,"end":809},"obj":"NN"},{"id":"T8731","span":{"begin":795,"end":800},"obj":"NN"},{"id":"T8730","span":{"begin":782,"end":794},"obj":"JJ"},{"id":"T8729","span":{"begin":778,"end":781},"obj":"CC"},{"id":"T8728","span":{"begin":768,"end":777},"obj":"JJ"},{"id":"T8727","span":{"begin":763,"end":767},"obj":"CC"},{"id":"T8726","span":{"begin":751,"end":762},"obj":"VB"},{"id":"T8725","span":{"begin":748,"end":750},"obj":"IN"},{"id":"T8724","span":{"begin":742,"end":747},"obj":"NN"},{"id":"T8723","span":{"begin":732,"end":741},"obj":"JJ"},{"id":"T8722","span":{"begin":726,"end":731},"obj":"VB"},{"id":"T8721","span":{"begin":721,"end":725},"obj":"NN"},{"id":"T8720","span":{"begin":716,"end":720},"obj":"IN"},{"id":"T8719","span":{"begin":711,"end":715},"obj":"NN"},{"id":"T8718","span":{"begin":707,"end":710},"obj":"DT"},{"id":"T8717","span":{"begin":696,"end":706},"obj":"VB"},{"id":"T8716","span":{"begin":694,"end":695},"obj":"-COMMA-"},{"id":"T8715","span":{"begin":693,"end":694},"obj":"-RRB-"},{"id":"T8714","span":{"begin":691,"end":693},"obj":"CD"},{"id":"T8713","span":{"begin":690,"end":691},"obj":"-LRB-"},{"id":"T8712","span":{"begin":682,"end":689},"obj":"NN"},{"id":"T8711","span":{"begin":676,"end":681},"obj":"NN"},{"id":"T8710","span":{"begin":663,"end":675},"obj":"JJ"},{"id":"T8709","span":{"begin":659,"end":662},"obj":"DT"},{"id":"T8708","span":{"begin":656,"end":658},"obj":"IN"},{"id":"T8707","span":{"begin":645,"end":655},"obj":"NN"},{"id":"T8706","span":{"begin":636,"end":644},"obj":"NN"},{"id":"T8705","span":{"begin":627,"end":635},"obj":"JJ"},{"id":"T8704","span":{"begin":624,"end":626},"obj":"IN"},{"id":"T8703","span":{"begin":620,"end":623},"obj":"NN"},{"id":"T8702","span":{"begin":605,"end":619},"obj":"VB"},{"id":"T8701","span":{"begin":600,"end":604},"obj":"NN"},{"id":"T8700","span":{"begin":595,"end":599},"obj":"IN"},{"id":"T8699","span":{"begin":582,"end":594},"obj":"VB"},{"id":"T8698","span":{"begin":578,"end":581},"obj":"VB"},{"id":"T8697","span":{"begin":572,"end":577},"obj":"NN"},{"id":"T8696","span":{"begin":565,"end":571},"obj":"JJ"},{"id":"T8695","span":{"begin":563,"end":564},"obj":"DT"},{"id":"T8694","span":{"begin":561,"end":562},"obj":"-COMMA-"},{"id":"T8693","span":{"begin":548,"end":561},"obj":"RB"},{"id":"T8692","span":{"begin":545,"end":546},"obj":"-RRB-"},{"id":"T8691","span":{"begin":543,"end":545},"obj":"CD"},{"id":"T8690","span":{"begin":542,"end":543},"obj":"-LRB-"},{"id":"T8689","span":{"begin":536,"end":541},"obj":"NN"},{"id":"T8688","span":{"begin":520,"end":535},"obj":"VB"},{"id":"T8687","span":{"begin":517,"end":519},"obj":"IN"},{"id":"T8686","span":{"begin":506,"end":516},"obj":"NN"},{"id":"T8685","span":{"begin":490,"end":505},"obj":"JJ"},{"id":"T8684","span":{"begin":477,"end":489},"obj":"VB"},{"id":"T8683","span":{"begin":474,"end":476},"obj":"TO"},{"id":"T8682","span":{"begin":470,"end":473},"obj":"CC"},{"id":"T8681","span":{"begin":464,"end":469},"obj":"NN"},{"id":"T8680","span":{"begin":456,"end":463},"obj":"JJ"},{"id":"T8679","span":{"begin":448,"end":455},"obj":"VB"},{"id":"T8678","span":{"begin":445,"end":447},"obj":"TO"},{"id":"T8677","span":{"begin":439,"end":444},"obj":"VB"},{"id":"T8676","span":{"begin":434,"end":438},"obj":"VB"},{"id":"T8675","span":{"begin":429,"end":433},"obj":"RB"},{"id":"T8674","span":{"begin":425,"end":428},"obj":"VB"},{"id":"T8673","span":{"begin":420,"end":424},"obj":"NN"},{"id":"T8672","span":{"begin":417,"end":418},"obj":"-RRB-"},{"id":"T8671","span":{"begin":415,"end":417},"obj":"CD"},{"id":"T8670","span":{"begin":414,"end":415},"obj":"-LRB-"},{"id":"T8669","span":{"begin":402,"end":413},"obj":"NN"},{"id":"T8668","span":{"begin":397,"end":401},"obj":"NN"},{"id":"T8667","span":{"begin":393,"end":396},"obj":"CC"},{"id":"T8666","span":{"begin":382,"end":392},"obj":"NN"},{"id":"T8665","span":{"begin":377,"end":381},"obj":"NN"},{"id":"T8664","span":{"begin":368,"end":376},"obj":"VB"},{"id":"T8663","span":{"begin":365,"end":367},"obj":"IN"},{"id":"T8662","span":{"begin":358,"end":364},"obj":"NN"},{"id":"T8661","span":{"begin":356,"end":357},"obj":"DT"},{"id":"T8660","span":{"begin":353,"end":355},"obj":"IN"},{"id":"T8659","span":{"begin":343,"end":352},"obj":"NN"},{"id":"T8658","span":{"begin":327,"end":342},"obj":"JJ"},{"id":"T8657","span":{"begin":324,"end":326},"obj":"IN"},{"id":"T8656","span":{"begin":313,"end":323},"obj":"NN"},{"id":"T8655","span":{"begin":303,"end":312},"obj":"VB"},{"id":"T8654","span":{"begin":298,"end":302},"obj":"VB"},{"id":"T8653","span":{"begin":293,"end":297},"obj":"NN"},{"id":"T8652","span":{"begin":284,"end":292},"obj":"JJ"},{"id":"T8651","span":{"begin":273,"end":283},"obj":"VB"},{"id":"T8650","span":{"begin":268,"end":272},"obj":"NN"},{"id":"T8649","span":{"begin":260,"end":267},"obj":"JJ"},{"id":"T8648","span":{"begin":257,"end":259},"obj":"CC"},{"id":"T8647","span":{"begin":252,"end":256},"obj":"NN"},{"id":"T8646","span":{"begin":237,"end":251},"obj":"JJ"},{"id":"T8645","span":{"begin":232,"end":236},"obj":"IN"},{"id":"T8644","span":{"begin":220,"end":231},"obj":"NN"},{"id":"T8643","span":{"begin":210,"end":218},"obj":"NN"},{"id":"T8642","span":{"begin":204,"end":209},"obj":"NN"},{"id":"T8641","span":{"begin":191,"end":203},"obj":"JJ"},{"id":"T8640","span":{"begin":187,"end":190},"obj":"CC"},{"id":"T8639","span":{"begin":177,"end":186},"obj":"JJ"},{"id":"T8638","span":{"begin":172,"end":176},"obj":"CC"},{"id":"T8637","span":{"begin":169,"end":171},"obj":"IN"},{"id":"T8636","span":{"begin":158,"end":168},"obj":"NN"},{"id":"T8635","span":{"begin":149,"end":157},"obj":"JJ"},{"id":"T8634","span":{"begin":145,"end":148},"obj":"DT"},{"id":"T8633","span":{"begin":142,"end":144},"obj":"IN"},{"id":"T8632","span":{"begin":137,"end":141},"obj":"NN"},{"id":"T8631","span":{"begin":127,"end":136},"obj":"JJ"},{"id":"T8630","span":{"begin":125,"end":126},"obj":"DT"},{"id":"T8629","span":{"begin":119,"end":124},"obj":"VB"},{"id":"T8628","span":{"begin":114,"end":118},"obj":"RB"},{"id":"T8627","span":{"begin":107,"end":113},"obj":"NN"},{"id":"T8626","span":{"begin":102,"end":106},"obj":"DT"},{"id":"T8625","span":{"begin":97,"end":101},"obj":"IN"},{"id":"T8624","span":{"begin":87,"end":96},"obj":"VB"},{"id":"T8623","span":{"begin":84,"end":86},"obj":"VB"},{"id":"T8622","span":{"begin":77,"end":83},"obj":"MD"},{"id":"T8621","span":{"begin":74,"end":76},"obj":"PRP"},{"id":"T8620","span":{"begin":72,"end":73},"obj":"-COMMA-"},{"id":"T8619","span":{"begin":65,"end":72},"obj":"NN"},{"id":"T8618","span":{"begin":59,"end":64},"obj":"NN"},{"id":"T8617","span":{"begin":45,"end":58},"obj":"JJ"},{"id":"T8616","span":{"begin":41,"end":44},"obj":"DT"},{"id":"T8615","span":{"begin":38,"end":40},"obj":"IN"},{"id":"T8614","span":{"begin":28,"end":37},"obj":"NN"},{"id":"T8613","span":{"begin":19,"end":27},"obj":"JJ"},{"id":"T8612","span":{"begin":17,"end":18},"obj":"DT"},{"id":"T8611","span":{"begin":14,"end":16},"obj":"VB"},{"id":"T8610","span":{"begin":9,"end":13},"obj":"NN"}],"relations":[{"id":"R5839","pred":"arg1Of","subj":"T8669","obj":"T8668"},{"id":"R5840","pred":"arg2Of","subj":"T8671","obj":"T8670"},{"id":"R5841","pred":"arg3Of","subj":"T8672","obj":"T8670"},{"id":"R5777","pred":"arg1Of","subj":"T8610","obj":"T8611"},{"id":"R5779","pred":"arg2Of","subj":"T8614","obj":"T8611"},{"id":"R5780","pred":"arg1Of","subj":"T8614","obj":"T8612"},{"id":"R5781","pred":"arg1Of","subj":"T8614","obj":"T8613"},{"id":"R5782","pred":"arg1Of","subj":"T8614","obj":"T8615"},{"id":"R5783","pred":"arg2Of","subj":"T8619","obj":"T8615"},{"id":"R5784","pred":"arg1Of","subj":"T8619","obj":"T8616"},{"id":"R5785","pred":"arg1Of","subj":"T8619","obj":"T8617"},{"id":"R5786","pred":"arg1Of","subj":"T8619","obj":"T8618"},{"id":"R5788","pred":"arg1Of","subj":"T8621","obj":"T8622"},{"id":"R5789","pred":"arg1Of","subj":"T8621","obj":"T8623"},{"id":"R5790","pred":"arg2Of","subj":"T8621","obj":"T8624"},{"id":"R5791","pred":"arg2Of","subj":"T8624","obj":"T8622"},{"id":"R5792","pred":"arg2Of","subj":"T8624","obj":"T8623"},{"id":"R5793","pred":"arg1Of","subj":"T8624","obj":"T8625"},{"id":"R5794","pred":"arg1Of","subj":"T8627","obj":"T8626"},{"id":"R5795","pred":"arg1Of","subj":"T8627","obj":"T8629"},{"id":"R5796","pred":"arg2Of","subj":"T8629","obj":"T8620"},{"id":"R5797","pred":"modOf","subj":"T8629","obj":"T8622"},{"id":"R5798","pred":"arg1Of","subj":"T8629","obj":"T8628"},{"id":"R5799","pred":"arg1Of","subj":"T8629","obj":"T8633"},{"id":"R5800","pred":"arg2Of","subj":"T8632","obj":"T8629"},{"id":"R5801","pred":"arg1Of","subj":"T8632","obj":"T8630"},{"id":"R5802","pred":"arg1Of","subj":"T8632","obj":"T8631"},{"id":"R5803","pred":"arg2Of","subj":"T8636","obj":"T8633"},{"id":"R5804","pred":"arg1Of","subj":"T8636","obj":"T8634"},{"id":"R5805","pred":"arg1Of","subj":"T8636","obj":"T8635"},{"id":"R5806","pred":"arg1Of","subj":"T8636","obj":"T8637"},{"id":"R5807","pred":"arg1Of","subj":"T8639","obj":"T8640"},{"id":"R5808","pred":"arg1Of","subj":"T8640","obj":"T8638"},{"id":"R5809","pred":"arg2Of","subj":"T8641","obj":"T8640"},{"id":"R5810","pred":"arg2Of","subj":"T8643","obj":"T8637"},{"id":"R5811","pred":"arg1Of","subj":"T8643","obj":"T8639"},{"id":"R5812","pred":"arg1Of","subj":"T8643","obj":"T8641"},{"id":"R5813","pred":"arg1Of","subj":"T8643","obj":"T8642"},{"id":"R5814","pred":"arg1Of","subj":"T8644","obj":"T8645"},{"id":"R5815","pred":"arg1Of","subj":"T8644","obj":"T8654"},{"id":"R5816","pred":"arg1Of","subj":"T8647","obj":"T8646"},{"id":"R5817","pred":"arg1Of","subj":"T8647","obj":"T8648"},{"id":"R5818","pred":"arg2Of","subj":"T8648","obj":"T8645"},{"id":"R5819","pred":"arg2Of","subj":"T8650","obj":"T8648"},{"id":"R5820","pred":"arg1Of","subj":"T8650","obj":"T8649"},{"id":"R5821","pred":"arg1Of","subj":"T8650","obj":"T8651"},{"id":"R5822","pred":"arg2Of","subj":"T8653","obj":"T8651"},{"id":"R5823","pred":"arg1Of","subj":"T8653","obj":"T8652"},{"id":"R5824","pred":"arg1Of","subj":"T8654","obj":"T8660"},{"id":"R5825","pred":"arg1Of","subj":"T8654","obj":"T8670"},{"id":"R5826","pred":"arg2Of","subj":"T8656","obj":"T8654"},{"id":"R5827","pred":"arg2Of","subj":"T8656","obj":"T8655"},{"id":"R5828","pred":"arg1Of","subj":"T8656","obj":"T8657"},{"id":"R5829","pred":"arg2Of","subj":"T8659","obj":"T8657"},{"id":"R5830","pred":"arg1Of","subj":"T8659","obj":"T8658"},{"id":"R5831","pred":"arg2Of","subj":"T8662","obj":"T8660"},{"id":"R5832","pred":"arg1Of","subj":"T8662","obj":"T8661"},{"id":"R5833","pred":"arg1Of","subj":"T8662","obj":"T8663"},{"id":"R5834","pred":"arg2Of","subj":"T8666","obj":"T8664"},{"id":"R5835","pred":"arg1Of","subj":"T8666","obj":"T8665"},{"id":"R5836","pred":"arg1Of","subj":"T8666","obj":"T8667"},{"id":"R5837","pred":"arg2Of","subj":"T8667","obj":"T8663"},{"id":"R5838","pred":"arg2Of","subj":"T8669","obj":"T8667"},{"id":"R5842","pred":"arg1Of","subj":"T8673","obj":"T8674"},{"id":"R5843","pred":"arg1Of","subj":"T8673","obj":"T8676"},{"id":"R5844","pred":"arg2Of","subj":"T8673","obj":"T8677"},{"id":"R5845","pred":"arg1Of","subj":"T8673","obj":"T8679"},{"id":"R5846","pred":"arg1Of","subj":"T8673","obj":"T8684"},{"id":"R5847","pred":"arg1Of","subj":"T8673","obj":"T8688"},{"id":"R5848","pred":"arg2Of","subj":"T8677","obj":"T8674"},{"id":"R5849","pred":"arg1Of","subj":"T8677","obj":"T8675"},{"id":"R5850","pred":"arg2Of","subj":"T8677","obj":"T8676"},{"id":"R5851","pred":"arg1Of","subj":"T8679","obj":"T8678"},{"id":"R5852","pred":"arg1Of","subj":"T8679","obj":"T8682"},{"id":"R5853","pred":"arg2Of","subj":"T8681","obj":"T8679"},{"id":"R5854","pred":"arg1Of","subj":"T8681","obj":"T8680"},{"id":"R5855","pred":"arg3Of","subj":"T8682","obj":"T8677"},{"id":"R5856","pred":"arg2Of","subj":"T8684","obj":"T8682"},{"id":"R5857","pred":"arg1Of","subj":"T8684","obj":"T8683"},{"id":"R5858","pred":"arg1Of","subj":"T8684","obj":"T8687"},{"id":"R5859","pred":"arg2Of","subj":"T8686","obj":"T8684"},{"id":"R5860","pred":"arg1Of","subj":"T8686","obj":"T8685"},{"id":"R5861","pred":"arg2Of","subj":"T8688","obj":"T8687"},{"id":"R5862","pred":"arg2Of","subj":"T8689","obj":"T8688"},{"id":"R5863","pred":"arg1Of","subj":"T8689","obj":"T8690"},{"id":"R5864","pred":"arg2Of","subj":"T8691","obj":"T8690"},{"id":"R5865","pred":"arg3Of","subj":"T8692","obj":"T8690"},{"id":"R5866","pred":"arg1Of","subj":"T8697","obj":"T8695"},{"id":"R5867","pred":"arg1Of","subj":"T8697","obj":"T8696"},{"id":"R5868","pred":"arg1Of","subj":"T8697","obj":"T8698"},{"id":"R5869","pred":"arg1Of","subj":"T8697","obj":"T8699"},{"id":"R5870","pred":"arg1Of","subj":"T8699","obj":"T8693"},{"id":"R5871","pred":"arg1Of","subj":"T8699","obj":"T8694"},{"id":"R5872","pred":"arg2Of","subj":"T8699","obj":"T8698"},{"id":"R5873","pred":"arg1Of","subj":"T8701","obj":"T8702"},{"id":"R5874","pred":"arg2Of","subj":"T8702","obj":"T8699"},{"id":"R5875","pred":"arg1Of","subj":"T8702","obj":"T8700"},{"id":"R5876","pred":"arg1Of","subj":"T8702","obj":"T8704"},{"id":"R5877","pred":"arg1Of","subj":"T8702","obj":"T8716"},{"id":"R5878","pred":"modOf","subj":"T8702","obj":"T8717"},{"id":"R5879","pred":"arg2Of","subj":"T8703","obj":"T8702"},{"id":"R5880","pred":"arg2Of","subj":"T8707","obj":"T8704"},{"id":"R5881","pred":"arg1Of","subj":"T8707","obj":"T8705"},{"id":"R5882","pred":"arg1Of","subj":"T8707","obj":"T8706"},{"id":"R5883","pred":"arg1Of","subj":"T8707","obj":"T8708"},{"id":"R5884","pred":"arg2Of","subj":"T8712","obj":"T8708"},{"id":"R5885","pred":"arg1Of","subj":"T8712","obj":"T8709"},{"id":"R5886","pred":"arg1Of","subj":"T8712","obj":"T8710"},{"id":"R5887","pred":"arg1Of","subj":"T8712","obj":"T8711"},{"id":"R5888","pred":"arg1Of","subj":"T8712","obj":"T8713"},{"id":"R5889","pred":"arg2Of","subj":"T8714","obj":"T8713"},{"id":"R5890","pred":"arg3Of","subj":"T8715","obj":"T8713"},{"id":"R5891","pred":"arg2Of","subj":"T8719","obj":"T8717"},{"id":"R5892","pred":"arg1Of","subj":"T8719","obj":"T8718"},{"id":"R5893","pred":"arg1Of","subj":"T8721","obj":"T8722"},{"id":"R5894","pred":"arg1Of","subj":"T8721","obj":"T8726"},{"id":"R5895","pred":"arg2Of","subj":"T8722","obj":"T8719"},{"id":"R5896","pred":"arg1Of","subj":"T8722","obj":"T8720"},{"id":"R5897","pred":"arg1Of","subj":"T8722","obj":"T8725"},{"id":"R5898","pred":"arg2Of","subj":"T8724","obj":"T8722"},{"id":"R5899","pred":"arg1Of","subj":"T8724","obj":"T8723"},{"id":"R5900","pred":"arg2Of","subj":"T8726","obj":"T8725"},{"id":"R5901","pred":"arg1Of","subj":"T8728","obj":"T8729"},{"id":"R5902","pred":"arg1Of","subj":"T8729","obj":"T8727"},{"id":"R5903","pred":"arg2Of","subj":"T8730","obj":"T8729"},{"id":"R5904","pred":"arg2Of","subj":"T8732","obj":"T8726"},{"id":"R5905","pred":"arg1Of","subj":"T8732","obj":"T8728"},{"id":"R5906","pred":"arg1Of","subj":"T8732","obj":"T8730"},{"id":"R5907","pred":"arg1Of","subj":"T8732","obj":"T8731"},{"id":"R5908","pred":"arg1Of","subj":"T8732","obj":"T8733"},{"id":"R5909","pred":"arg2Of","subj":"T8735","obj":"T8733"},{"id":"R5910","pred":"arg1Of","subj":"T8735","obj":"T8734"},{"id":"R5911","pred":"arg1Of","subj":"T8735","obj":"T8736"},{"id":"R5912","pred":"arg2Of","subj":"T8739","obj":"T8736"},{"id":"R5913","pred":"arg1Of","subj":"T8739","obj":"T8737"},{"id":"R5914","pred":"arg1Of","subj":"T8739","obj":"T8738"},{"id":"R5915","pred":"arg1Of","subj":"T8739","obj":"T8740"},{"id":"R5916","pred":"arg2Of","subj":"T8741","obj":"T8740"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":"Although IKK1 is a critical component of the non-canonical NF-κB pathway, it should be mentioned that this kinase also plays a prominent role in the negative regulation of both canonical and noncanonical NF-κB pathways. Macrophages from IKK1-deficient mice or knockin mice expressing inactive IKK1 show increased production of proinflammatory cytokines as a result of enhanced IKK2 activation and IκBα degradation [34]. IKK1 has also been shown to inhibit nuclear NF-κB and to downregulate proinflammatory signalling by phosphorylating STAT1 [35]. Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback regulation of the noncanonical NF-κB pathway [36], supporting the idea that IKK1 plays important roles in terminating both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA."}

{"project":"GO-BP","denotations":[{"id":"T8747","span":{"begin":645,"end":655},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T8746","span":{"begin":158,"end":168},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T8757","span":{"begin":620,"end":623},"obj":"http://purl.obolibrary.org/obo/GO_0004704"},{"id":"T8756","span":{"begin":402,"end":413},"obj":"http://purl.obolibrary.org/obo/GO_0009056"},{"id":"T8752","span":{"begin":506,"end":516},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"Although IKK1 is a critical component of the non-canonical NF-κB pathway, it should be mentioned that this kinase also plays a prominent role in the negative regulation of both canonical and noncanonical NF-κB pathways. Macrophages from IKK1-deficient mice or knockin mice expressing inactive IKK1 show increased production of proinflammatory cytokines as a result of enhanced IKK2 activation and IκBα degradation [34]. IKK1 has also been shown to inhibit nuclear NF-κB and to downregulate proinflammatory signalling by phosphorylating STAT1 [35]. Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback regulation of the noncanonical NF-κB pathway [36], supporting the idea that IKK1 plays important roles in terminating both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA."}

{"project":"GO-MF","denotations":[{"id":"T8758","span":{"begin":620,"end":623},"obj":"http://purl.obolibrary.org/obo/GO_0004704"}],"text":"Although IKK1 is a critical component of the non-canonical NF-κB pathway, it should be mentioned that this kinase also plays a prominent role in the negative regulation of both canonical and noncanonical NF-κB pathways. Macrophages from IKK1-deficient mice or knockin mice expressing inactive IKK1 show increased production of proinflammatory cytokines as a result of enhanced IKK2 activation and IκBα degradation [34]. IKK1 has also been shown to inhibit nuclear NF-κB and to downregulate proinflammatory signalling by phosphorylating STAT1 [35]. Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback regulation of the noncanonical NF-κB pathway [36], supporting the idea that IKK1 plays important roles in terminating both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA."}

{"project":"sentences","denotations":[{"id":"T8388","span":{"begin":548,"end":879},"obj":"Sentence"},{"id":"T8387","span":{"begin":420,"end":547},"obj":"Sentence"},{"id":"T8386","span":{"begin":220,"end":419},"obj":"Sentence"},{"id":"T95","span":{"begin":0,"end":219},"obj":"Sentence"},{"id":"T96","span":{"begin":220,"end":419},"obj":"Sentence"},{"id":"T97","span":{"begin":420,"end":547},"obj":"Sentence"},{"id":"T98","span":{"begin":548,"end":879},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Although IKK1 is a critical component of the non-canonical NF-κB pathway, it should be mentioned that this kinase also plays a prominent role in the negative regulation of both canonical and noncanonical NF-κB pathways. Macrophages from IKK1-deficient mice or knockin mice expressing inactive IKK1 show increased production of proinflammatory cytokines as a result of enhanced IKK2 activation and IκBα degradation [34]. IKK1 has also been shown to inhibit nuclear NF-κB and to downregulate proinflammatory signalling by phosphorylating STAT1 [35]. Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback regulation of the noncanonical NF-κB pathway [36], supporting the idea that IKK1 plays important roles in terminating both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA."}

{"project":"simple1","denotations":[{"id":"T8773","span":{"begin":721,"end":725},"obj":"Protein"},{"id":"T8772","span":{"begin":620,"end":623},"obj":"Protein"},{"id":"T8771","span":{"begin":600,"end":604},"obj":"Protein"},{"id":"T8770","span":{"begin":536,"end":541},"obj":"Protein"},{"id":"T8769","span":{"begin":420,"end":424},"obj":"Protein"},{"id":"T8768","span":{"begin":397,"end":401},"obj":"Protein"},{"id":"T8767","span":{"begin":377,"end":381},"obj":"Protein"},{"id":"T8766","span":{"begin":293,"end":297},"obj":"Protein"},{"id":"T8765","span":{"begin":237,"end":241},"obj":"Protein"},{"id":"T8764","span":{"begin":9,"end":13},"obj":"Protein"}],"text":"Although IKK1 is a critical component of the non-canonical NF-κB pathway, it should be mentioned that this kinase also plays a prominent role in the negative regulation of both canonical and noncanonical NF-κB pathways. Macrophages from IKK1-deficient mice or knockin mice expressing inactive IKK1 show increased production of proinflammatory cytokines as a result of enhanced IKK2 activation and IκBα degradation [34]. IKK1 has also been shown to inhibit nuclear NF-κB and to downregulate proinflammatory signalling by phosphorylating STAT1 [35]. Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback regulation of the noncanonical NF-κB pathway [36], supporting the idea that IKK1 plays important roles in terminating both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T9289","span":{"begin":605,"end":619},"obj":"Phosphorylation"},{"id":"T9288","span":{"begin":520,"end":535},"obj":"Phosphorylation"},{"id":"T9287","span":{"begin":368,"end":376},"obj":"Positive_regulation"},{"id":"T9286","span":{"begin":402,"end":413},"obj":"Protein_catabolism"},{"id":"T9285","span":{"begin":358,"end":364},"obj":"Positive_regulation"},{"id":"T9284","span":{"begin":273,"end":283},"obj":"Gene_expression"},{"id":"T9283","span":{"begin":382,"end":392},"obj":"Positive_regulation"},{"id":"T9282","span":{"begin":242,"end":251},"obj":"Negative_regulation"},{"id":"T9281","span":{"begin":721,"end":725},"obj":"Protein"},{"id":"T9280","span":{"begin":620,"end":623},"obj":"Protein"},{"id":"T9279","span":{"begin":600,"end":604},"obj":"Protein"},{"id":"T9278","span":{"begin":420,"end":424},"obj":"Protein"},{"id":"T9277","span":{"begin":536,"end":541},"obj":"Protein"},{"id":"T9276","span":{"begin":397,"end":401},"obj":"Protein"},{"id":"T9275","span":{"begin":377,"end":381},"obj":"Protein"},{"id":"T9274","span":{"begin":293,"end":297},"obj":"Protein"},{"id":"T9273","span":{"begin":237,"end":241},"obj":"Protein"},{"id":"T9272","span":{"begin":9,"end":13},"obj":"Protein"}],"relations":[{"id":"R6305","pred":"themeOf","subj":"T9273","obj":"T9282"},{"id":"R6306","pred":"themeOf","subj":"T9274","obj":"T9284"},{"id":"R6307","pred":"themeOf","subj":"T9275","obj":"T9283"},{"id":"R6308","pred":"themeOf","subj":"T9276","obj":"T9286"},{"id":"R6309","pred":"themeOf","subj":"T9277","obj":"T9288"},{"id":"R6310","pred":"themeOf","subj":"T9280","obj":"T9289"},{"id":"R6311","pred":"themeOf","subj":"T9283","obj":"T9287"},{"id":"R6312","pred":"themeOf","subj":"T9284","obj":"T9282"},{"id":"R6313","pred":"themeOf","subj":"T9286","obj":"T9285"}],"text":"Although IKK1 is a critical component of the non-canonical NF-κB pathway, it should be mentioned that this kinase also plays a prominent role in the negative regulation of both canonical and noncanonical NF-κB pathways. Macrophages from IKK1-deficient mice or knockin mice expressing inactive IKK1 show increased production of proinflammatory cytokines as a result of enhanced IKK2 activation and IκBα degradation [34]. IKK1 has also been shown to inhibit nuclear NF-κB and to downregulate proinflammatory signalling by phosphorylating STAT1 [35]. Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback regulation of the noncanonical NF-κB pathway [36], supporting the idea that IKK1 plays important roles in terminating both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA."}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T9148","span":{"begin":605,"end":619},"obj":"Phosphorylation"},{"id":"T9147","span":{"begin":520,"end":535},"obj":"Phosphorylation"},{"id":"T9146","span":{"begin":368,"end":376},"obj":"Positive_regulation"},{"id":"T9145","span":{"begin":242,"end":251},"obj":"Negative_regulation"},{"id":"T9144","span":{"begin":358,"end":364},"obj":"Positive_regulation"},{"id":"T9143","span":{"begin":402,"end":413},"obj":"Protein_catabolism"},{"id":"T9142","span":{"begin":382,"end":392},"obj":"Positive_regulation"},{"id":"T9141","span":{"begin":273,"end":283},"obj":"Gene_expression"},{"id":"T9140","span":{"begin":721,"end":725},"obj":"Protein"},{"id":"T9139","span":{"begin":620,"end":623},"obj":"Protein"},{"id":"T9138","span":{"begin":600,"end":604},"obj":"Protein"},{"id":"T9137","span":{"begin":420,"end":424},"obj":"Protein"},{"id":"T9136","span":{"begin":536,"end":541},"obj":"Protein"},{"id":"T9135","span":{"begin":397,"end":401},"obj":"Protein"},{"id":"T9134","span":{"begin":377,"end":381},"obj":"Protein"},{"id":"T9133","span":{"begin":293,"end":297},"obj":"Protein"},{"id":"T9132","span":{"begin":237,"end":241},"obj":"Protein"},{"id":"T9131","span":{"begin":9,"end":13},"obj":"Protein"}],"relations":[{"id":"R6247","pred":"themeOf","subj":"T9132","obj":"T9145"},{"id":"R6248","pred":"themeOf","subj":"T9133","obj":"T9141"},{"id":"R6249","pred":"themeOf","subj":"T9134","obj":"T9142"},{"id":"R6250","pred":"themeOf","subj":"T9135","obj":"T9143"},{"id":"R6251","pred":"themeOf","subj":"T9136","obj":"T9147"},{"id":"R6252","pred":"themeOf","subj":"T9139","obj":"T9148"},{"id":"R6253","pred":"themeOf","subj":"T9142","obj":"T9146"},{"id":"R6254","pred":"themeOf","subj":"T9143","obj":"T9144"}],"text":"Although IKK1 is a critical component of the non-canonical NF-κB pathway, it should be mentioned that this kinase also plays a prominent role in the negative regulation of both canonical and noncanonical NF-κB pathways. Macrophages from IKK1-deficient mice or knockin mice expressing inactive IKK1 show increased production of proinflammatory cytokines as a result of enhanced IKK2 activation and IκBα degradation [34]. IKK1 has also been shown to inhibit nuclear NF-κB and to downregulate proinflammatory signalling by phosphorylating STAT1 [35]. Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback regulation of the noncanonical NF-κB pathway [36], supporting the idea that IKK1 plays important roles in terminating both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA."}

{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T9339","span":{"begin":645,"end":681},"obj":"Regulation"},{"id":"T9338","span":{"begin":520,"end":546},"obj":"Phosphorylation"},{"id":"T9337","span":{"begin":397,"end":413},"obj":"Protein_catabolism"},{"id":"T9335","span":{"begin":368,"end":392},"obj":"Positive_regulation"},{"id":"T9334","span":{"begin":448,"end":469},"obj":"Negative_regulation"},{"id":"T9333","span":{"begin":273,"end":297},"obj":"Gene_expression"},{"id":"T9330","span":{"begin":548,"end":644},"obj":"Phosphorylation"},{"id":"T9329","span":{"begin":368,"end":392},"obj":"Positive_regulation"},{"id":"T9328","span":{"begin":303,"end":323},"obj":"Positive_regulation"},{"id":"T9324","span":{"begin":237,"end":241},"obj":"Protein"},{"id":"T9322","span":{"begin":763,"end":878},"obj":"Protein"},{"id":"T9321","span":{"begin":102,"end":113},"obj":"Protein"},{"id":"T9320","span":{"begin":252,"end":256},"obj":"Protein"},{"id":"T9319","span":{"begin":284,"end":297},"obj":"Protein"},{"id":"T9318","span":{"begin":9,"end":13},"obj":"Protein"},{"id":"T9317","span":{"begin":716,"end":725},"obj":"Protein"},{"id":"T9316","span":{"begin":536,"end":546},"obj":"Protein"},{"id":"T9315","span":{"begin":876,"end":878},"obj":"Protein"},{"id":"T9313","span":{"begin":600,"end":604},"obj":"Protein"},{"id":"T9311","span":{"begin":397,"end":401},"obj":"Protein"},{"id":"T9308","span":{"begin":620,"end":623},"obj":"Protein"},{"id":"T9305","span":{"begin":377,"end":381},"obj":"Protein"},{"id":"T9301","span":{"begin":220,"end":241},"obj":"Entity"},{"id":"T9300","span":{"begin":656,"end":681},"obj":"Protein"},{"id":"T9298","span":{"begin":420,"end":424},"obj":"Protein"},{"id":"T9296","span":{"begin":38,"end":73},"obj":"Protein"},{"id":"T9294","span":{"begin":169,"end":218},"obj":"Protein"},{"id":"T9292","span":{"begin":456,"end":469},"obj":"Protein"}],"relations":[{"id":"R6314","pred":"themeOf","subj":"T9292","obj":"T9334"},{"id":"R6315","pred":"themeOf","subj":"T9300","obj":"T9339"},{"id":"R6317","pred":"themeOf","subj":"T9305","obj":"T9335"},{"id":"R6320","pred":"themeOf","subj":"T9308","obj":"T9330"},{"id":"R6321","pred":"themeOf","subj":"T9311","obj":"T9337"},{"id":"R6322","pred":"causeOf","subj":"T9313","obj":"T9330"},{"id":"R6323","pred":"themeOf","subj":"T9316","obj":"T9338"},{"id":"R6324","pred":"themeOf","subj":"T9319","obj":"T9333"},{"id":"R6326","pred":"themeOf","subj":"T9335","obj":"T9329"}],"text":"Although IKK1 is a critical component of the non-canonical NF-κB pathway, it should be mentioned that this kinase also plays a prominent role in the negative regulation of both canonical and noncanonical NF-κB pathways. Macrophages from IKK1-deficient mice or knockin mice expressing inactive IKK1 show increased production of proinflammatory cytokines as a result of enhanced IKK2 activation and IκBα degradation [34]. IKK1 has also been shown to inhibit nuclear NF-κB and to downregulate proinflammatory signalling by phosphorylating STAT1 [35]. Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback regulation of the noncanonical NF-κB pathway [36], supporting the idea that IKK1 plays important roles in terminating both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T9228","span":{"begin":605,"end":619},"obj":"Phosphorylation"},{"id":"T9227","span":{"begin":605,"end":619},"obj":"Phosphorylation"},{"id":"T9226","span":{"begin":795,"end":800},"obj":"Protein"},{"id":"T9225","span":{"begin":721,"end":725},"obj":"Protein"},{"id":"T9224","span":{"begin":676,"end":681},"obj":"Protein"},{"id":"T9223","span":{"begin":620,"end":623},"obj":"Protein"},{"id":"T9222","span":{"begin":600,"end":604},"obj":"Protein"},{"id":"T9221","span":{"begin":448,"end":455},"obj":"Negative_regulation"},{"id":"T9220","span":{"begin":520,"end":535},"obj":"Phosphorylation"},{"id":"T9219","span":{"begin":536,"end":541},"obj":"Protein"},{"id":"T9218","span":{"begin":456,"end":469},"obj":"Protein"},{"id":"T9217","span":{"begin":420,"end":424},"obj":"Protein"},{"id":"T9216","span":{"begin":242,"end":251},"obj":"Negative_regulation"},{"id":"T9215","span":{"begin":368,"end":376},"obj":"Positive_regulation"},{"id":"T9214","span":{"begin":368,"end":376},"obj":"Positive_regulation"},{"id":"T9213","span":{"begin":273,"end":283},"obj":"Gene_expression"},{"id":"T9212","span":{"begin":242,"end":251},"obj":"Negative_regulation"},{"id":"T9211","span":{"begin":397,"end":418},"obj":"Protein"},{"id":"T9210","span":{"begin":377,"end":381},"obj":"Protein"},{"id":"T9209","span":{"begin":293,"end":297},"obj":"Protein"},{"id":"T9208","span":{"begin":237,"end":241},"obj":"Protein"},{"id":"T9207","span":{"begin":204,"end":209},"obj":"Protein"},{"id":"T9206","span":{"begin":59,"end":64},"obj":"Protein"},{"id":"T9205","span":{"begin":9,"end":13},"obj":"Protein"}],"relations":[{"id":"R6280","pred":"themeOf","subj":"T9208","obj":"T9212"},{"id":"R6281","pred":"themeOf","subj":"T9209","obj":"T9213"},{"id":"R6282","pred":"themeOf","subj":"T9210","obj":"T9214"},{"id":"R6283","pred":"themeOf","subj":"T9211","obj":"T9215"},{"id":"R6284","pred":"themeOf","subj":"T9213","obj":"T9216"},{"id":"R6285","pred":"themeOf","subj":"T9218","obj":"T9221"},{"id":"R6286","pred":"themeOf","subj":"T9219","obj":"T9220"},{"id":"R6287","pred":"Cause","subj":"T9221","obj":"T9220"},{"id":"R6288","pred":"themeOf","subj":"T9222","obj":"T9227"},{"id":"R6289","pred":"themeOf","subj":"T9223","obj":"T9228"}],"text":"Although IKK1 is a critical component of the non-canonical NF-κB pathway, it should be mentioned that this kinase also plays a prominent role in the negative regulation of both canonical and noncanonical NF-κB pathways. Macrophages from IKK1-deficient mice or knockin mice expressing inactive IKK1 show increased production of proinflammatory cytokines as a result of enhanced IKK2 activation and IκBα degradation [34]. IKK1 has also been shown to inhibit nuclear NF-κB and to downregulate proinflammatory signalling by phosphorylating STAT1 [35]. Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback regulation of the noncanonical NF-κB pathway [36], supporting the idea that IKK1 plays important roles in terminating both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA."}

{"project":"test3","denotations":[{"id":"T8378","span":{"begin":721,"end":725},"obj":"Protein"},{"id":"T8377","span":{"begin":620,"end":623},"obj":"Protein"},{"id":"T8376","span":{"begin":600,"end":604},"obj":"Protein"},{"id":"T8375","span":{"begin":536,"end":541},"obj":"Protein"},{"id":"T8374","span":{"begin":420,"end":424},"obj":"Protein"},{"id":"T8373","span":{"begin":402,"end":413},"obj":"Protein_catabolism"},{"id":"T8372","span":{"begin":397,"end":401},"obj":"Protein"},{"id":"T8371","span":{"begin":382,"end":392},"obj":"Positive_regulation"},{"id":"T8370","span":{"begin":377,"end":381},"obj":"Protein"},{"id":"T8369","span":{"begin":368,"end":376},"obj":"Positive_regulation"},{"id":"T8368","span":{"begin":293,"end":297},"obj":"Protein"},{"id":"T8367","span":{"begin":273,"end":283},"obj":"Gene_expression"},{"id":"T8366","span":{"begin":242,"end":251},"obj":"Negative_regulation"},{"id":"T8365","span":{"begin":237,"end":241},"obj":"Protein"},{"id":"T8364","span":{"begin":9,"end":13},"obj":"Protein"},{"id":"T8360","span":{"begin":721,"end":725},"obj":"Protein"},{"id":"T8359","span":{"begin":620,"end":623},"obj":"Protein"},{"id":"T8358","span":{"begin":600,"end":604},"obj":"Protein"},{"id":"T8357","span":{"begin":536,"end":541},"obj":"Protein"},{"id":"T8356","span":{"begin":420,"end":424},"obj":"Protein"},{"id":"T8355","span":{"begin":397,"end":401},"obj":"Protein"},{"id":"T8354","span":{"begin":377,"end":381},"obj":"Protein"},{"id":"T8353","span":{"begin":293,"end":297},"obj":"Protein"},{"id":"T8352","span":{"begin":237,"end":241},"obj":"Protein"},{"id":"T8351","span":{"begin":9,"end":13},"obj":"Protein"}],"relations":[{"id":"R5571","pred":"themeOf","subj":"T8365","obj":"T8366"},{"id":"R5572","pred":"themeOf","subj":"T8368","obj":"T8367"},{"id":"R5573","pred":"themeOf","subj":"T8370","obj":"T8373"},{"id":"R5574","pred":"themeOf","subj":"T8370","obj":"T8371"},{"id":"R5575","pred":"themeOf","subj":"T8371","obj":"T8369"},{"id":"R5576","pred":"themeOf","subj":"T8372","obj":"T8373"},{"id":"R5577","pred":"themeOf","subj":"T8373","obj":"T8369"}],"text":"Although IKK1 is a critical component of the non-canonical NF-κB pathway, it should be mentioned that this kinase also plays a prominent role in the negative regulation of both canonical and noncanonical NF-κB pathways. Macrophages from IKK1-deficient mice or knockin mice expressing inactive IKK1 show increased production of proinflammatory cytokines as a result of enhanced IKK2 activation and IκBα degradation [34]. IKK1 has also been shown to inhibit nuclear NF-κB and to downregulate proinflammatory signalling by phosphorylating STAT1 [35]. Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback regulation of the noncanonical NF-κB pathway [36], supporting the idea that IKK1 plays important roles in terminating both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA."}