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testone

Id Subject Object Predicate Lexical cue
T21324 14740-14751 Protein_catabolism denotes degradation
T21323 14649-14664 Phosphorylation denotes phosphorylation
T21322 14629-14637 Positive_regulation denotes mediates
T21321 14588-14602 Phosphorylation denotes phosphorylates
T21320 14545-14554 Positive_regulation denotes increased
T21319 14253-14262 Binding denotes recruited
T21318 14179-14190 Protein_catabolism denotes degradation
T21317 13987-13997 Gene_expression denotes expression
T21316 15143-15165 Protein denotes tumour necrosis factor
T21315 15138-15141 Protein denotes TNF
T21314 15071-15098 Protein denotes receptor activator of NF-κB
T21313 15065-15069 Protein denotes RANK
T21312 14846-14851 Protein denotes TRAF1
T21311 14839-14844 Protein denotes TRAF3
T21310 14799-14803 Protein denotes RelB
T21309 14763-14766 Protein denotes p52
T21308 14755-14759 Protein denotes p100
T21307 14644-14648 Protein denotes p100
T21306 14617-14621 Protein denotes IKK1
T21305 14579-14582 Protein denotes NIK
T21304 14555-14558 Protein denotes NIK
T21303 14513-14516 Protein denotes NIK
T21302 14491-14496 Protein denotes TRAF3
T21301 14473-14476 Protein denotes NIK
T21300 14454-14459 Protein denotes TRAF3
T21299 14407-14408 Protein denotes 2
T21298 14401-14406 Protein denotes cIAP1
T21297 14354-14355 Protein denotes 2
T21296 14348-14353 Protein denotes cIAP1
T21295 14286-14291 Protein denotes TRAF2
T21294 14244-14249 Protein denotes TRAF3
T21293 14207-14210 Protein denotes NIK
T21292 14194-14197 Protein denotes NIK
T21291 14108-14109 Protein denotes 2
T21290 14102-14107 Protein denotes cIAP1
T21289 14092-14097 Protein denotes TRAF3
T21288 14085-14090 Protein denotes TRAF2
T21287 14028-14031 Protein denotes NIK
T21286 13982-13985 Protein denotes NIK
T21285 13959-13980 Protein denotes NF-κB inducing kinase
T21284 13889-13893 Protein denotes RANK
T21283 13880-13884 Protein denotes CD40
T19331 10316-10325 Negative_regulation denotes inhibitor
T19330 10010-10017 Binding denotes binding
T19329 9988-9995 Negative_regulation denotes compete
T19328 9914-9923 Negative_regulation denotes inhibited
T19327 9847-9857 Gene_expression denotes expression
T19326 9836-9846 Negative_regulation denotes inhibiting
T19325 9727-9734 Binding denotes binding
T19324 9692-9701 Binding denotes recruited
T19323 9356-9363 Entity denotes nucleus
T19322 9337-9348 Localization denotes translocate
T19321 9258-9269 Protein_catabolism denotes degradation
T19320 9180-9194 Phosphorylation denotes phosphorylates
T19319 8829-8837 Positive_regulation denotes inducing
T19318 8689-8700 Binding denotes recruitment
T19317 8677-8684 Positive_regulation denotes trigger
T19316 8599-8609 Binding denotes engagement
T19315 10701-10723 Protein denotes tumour necrosis factor
T19314 10696-10699 Protein denotes TNF
T19313 10558-10600 Protein denotes single-immunoglobulinIL-1 receptor-related
T19312 10550-10556 Protein denotes SIGIRR
T19311 10518-10548 Protein denotes receptor interacting protein 1
T19310 10512-10516 Protein denotes RIP1
T19309 10483-10510 Protein denotes receptor activator of NF-κB
T19308 10477-10481 Protein denotes RANK
T19307 10430-10455 Protein denotes NF-κB essential modulator
T19306 10424-10428 Protein denotes NEMO
T19305 10374-10422 Protein denotes myeloid differentiation primary response gene 88
T19304 10367-10372 Protein denotes MyD88
T19303 10277-10292 Protein denotes cylindromatosis
T19302 10271-10275 Protein denotes CYLD
T19301 10200-10230 Protein denotes A20-binding inhibitor of NF-κB
T19300 10194-10198 Protein denotes ABIN
T19299 10031-10036 Protein denotes TRAF6
T19298 10021-10026 Protein denotes IRAK1
T19297 10001-10005 Protein denotes TLR4
T19296 9953-9959 Protein denotes SIGIRR
T19295 9871-9876 Protein denotes TRAF6
T19294 9861-9866 Protein denotes IRAK1
T19293 9771-9774 Protein denotes p62
T19292 9760-9766 Protein denotes ABIN-1
T19291 9667-9672 Protein denotes TRAF6
T19290 9658-9662 Protein denotes RIP1
T19289 9542-9546 Protein denotes CYLD
T19288 9534-9537 Protein denotes A20
T19287 9400-9405 Protein denotes TRAF1
T19286 9329-9332 Protein denotes p50
T19285 9321-9324 Protein denotes p65
T19284 9195-9199 Protein denotes IκBα
T19283 9160-9164 Protein denotes IKK2
T19282 9121-9125 Protein denotes TAK1
T19281 9115-9119 Protein denotes TAK1
T19280 9106-9110 Protein denotes IKK2
T19279 9023-9027 Protein denotes NEMO
T19278 8999-9004 Protein denotes IRAK1
T19277 8990-8994 Protein denotes RIP1
T19276 8926-8931 Protein denotes cIAP2
T19275 8919-8924 Protein denotes cIAP1
T19274 8912-8917 Protein denotes TRAF6
T19273 8905-8910 Protein denotes TRAF2
T19272 8874-8879 Protein denotes IRAK4
T19271 8867-8872 Protein denotes IRAK1
T19270 8861-8865 Protein denotes RIP1
T19269 8844-8848 Protein denotes TRIF
T19268 8799-8842 Protein denotes TIR domain-containing adaptor-inducing IFNβ
T19267 8794-8797 Protein denotes MAL
T19266 8787-8792 Protein denotes MyD88
T19265 8779-8784 Protein denotes TRADD
T19264 8731-8777 Protein denotes TNF receptor 1-associated death domain protein
T19263 8672-8676 Protein denotes TLR4
T19262 8662-8666 Protein denotes RANK
T19261 8656-8660 Protein denotes CD40
T19260 8649-8654 Protein denotes TNFR1
T17361 32702-32712 Gene_expression denotes expression
T17360 32531-32540 Localization denotes secretion
T17359 32521-32530 Positive_regulation denotes increased
T17358 32481-32489 Positive_regulation denotes elevated
T17357 32341-32350 Regulation denotes regulator
T17356 31934-31944 Gene_expression denotes expression
T17355 31684-31694 Gene_expression denotes production
T17354 31672-31679 Positive_regulation denotes promote
T17353 31509-31516 Negative_regulation denotes prevent
T17352 31458-31472 Positive_regulation denotes overexpression
T17351 31269-31278 Gene_expression denotes producing
T17350 31237-31250 Gene_expression denotes overexpressed
T17349 31067-31076 Gene_expression denotes expressed
T17348 30952-30958 Binding denotes target
T17347 30689-30696 Positive_regulation denotes induced
T17346 30444-30448 Binding denotes bind
T17345 32659-32666 Protein denotes miR-223
T17344 32646-32653 Protein denotes miR-132
T17343 32638-32644 Protein denotes miR-16
T17342 32575-32579 Protein denotes IL-6
T17341 32544-32570 Protein denotes matrix metalloproteinase-1
T17340 32500-32507 Protein denotes miR-203
T17339 32368-32402 Protein denotes monocyte chemoattractant protein 1
T17338 32324-32332 Protein denotes miR-124a
T17337 32152-32159 Protein denotes miR-155
T17336 31754-31761 Protein denotes miR-155
T17335 31680-31683 Protein denotes TNF
T17334 31651-31658 Protein denotes miR-155
T17333 31450-31457 Protein denotes miR-155
T17332 31364-31372 Protein denotes miR-146a
T17331 31263-31268 Protein denotes IL-17
T17330 31254-31257 Protein denotes CD4
T17329 31220-31228 Protein denotes miR-146a
T17328 31055-31062 Protein denotes miR-155
T17327 31015-31019 Protein denotes RIP1
T17326 31006-31010 Protein denotes IKKε
T17325 30931-30938 Protein denotes miR-155
T17324 30894-30902 Protein denotes miR-146a
T17323 30853-30858 Protein denotes TRAF6
T17322 30843-30848 Protein denotes IRAK1
T17321 30771-30779 Protein denotes miR-146a
T17320 30736-30739 Protein denotes TNF
T17319 30729-30734 Protein denotes IL-1β
T17318 30590-30597 Protein denotes miR-155
T17317 30584-30585 Protein denotes b
T17316 30575-30583 Protein denotes miR-146a
T16314 29761-29769 Binding denotes interact
T16313 29720-29727 Binding denotes recruit
T16312 29639-29646 Binding denotes binding
T16311 29336-29345 Negative_regulation denotes deficient
T16310 29128-29137 Negative_regulation denotes deficient
T16309 29110-29120 Positive_regulation denotes activation
T16308 29059-29073 Positive_regulation denotes overexpression
T16307 29038-29047 Positive_regulation denotes inducible
T16306 29015-29025 Gene_expression denotes Expression
T16305 30190-30195 Protein denotes TRAF1
T16304 30057-30062 Protein denotes TRAF1
T16303 29955-29960 Protein denotes TRAF1
T16302 29728-29731 Protein denotes A20
T16301 29708-29713 Protein denotes TRAF1
T16300 29595-29600 Protein denotes TRAF1
T16299 29528-29533 Protein denotes TRAF1
T16298 29426-29431 Protein denotes TRAF2
T16297 29330-29335 Protein denotes TRAF1
T16296 29299-29303 Protein denotes CD40
T16295 29251-29256 Protein denotes TRAF1
T16294 29170-29173 Protein denotes TNF
T16293 29122-29127 Protein denotes TRAF1
T16292 29092-29095 Protein denotes TNF
T16291 29077-29082 Protein denotes TRAF1
T16290 29051-29054 Protein denotes TNF
T16289 29029-29034 Protein denotes TRAF1
T16288 28862-28867 Protein denotes TRAF1
T16287 28798-28807 Protein denotes ubiquitin
T16286 28688-28693 Protein denotes TRAF1
T16285 28655-28687 Protein denotes TNF receptor-associated factor 1
T15442 28574-28584 Gene_expression denotes expression
T15441 28436-28446 Gene_expression denotes expression
T15440 28391-28401 Gene_expression denotes expression
T15439 28219-28228 Negative_regulation denotes deficient
T15438 27898-27907 Gene_expression denotes expressed
T15437 27616-27627 Binding denotes interaction
T15436 27553-27562 Negative_regulation denotes inhibitor
T15435 28594-28600 Protein denotes SIGIRR
T15434 28510-28516 Protein denotes SIGIRR
T15433 28405-28411 Protein denotes SIGIRR
T15432 28212-28218 Protein denotes SIGIRR
T15431 28168-28174 Protein denotes SIGIRR
T15430 28019-28025 Protein denotes SIGIRR
T15429 27843-27849 Protein denotes SIGIRR
T15428 27813-27819 Protein denotes SIGIRR
T15427 27717-27722 Protein denotes IL-1R
T15426 27666-27671 Protein denotes TRAF6
T15425 27657-27662 Protein denotes IRAK1
T15424 27650-27655 Protein denotes MyD88
T15423 27566-27571 Protein denotes IL-1R
T15422 27464-27469 Protein denotes TIR-8
T15421 27433-27439 Protein denotes SIGIRR
T15420 27388-27431 Protein denotes Single-immunoglobulin IL-1 receptor-related
T15419 27336-27379 Protein denotes Single-immunoglobulin IL-1 receptor-related
T14064 26763-26766 Positive_regulation denotes via
T14063 26730-26739 Binding denotes recruited
T14062 26696-26703 Positive_regulation denotes induced
T14061 26635-26645 Gene_expression denotes expression
T14060 26593-26600 Gene_expression denotes produce
T14059 25997-26006 Gene_expression denotes expressed
T14058 27244-27248 Protein denotes CYLD
T14057 27135-27139 Protein denotes RANK
T14056 27106-27110 Protein denotes CYLD
T14055 26993-26996 Protein denotes p62
T14054 26896-26901 Protein denotes TRAF6
T14053 26862-26866 Protein denotes CYLD
T14052 26824-26838 Protein denotes sequestosome 1
T14051 26805-26808 Protein denotes p62
T14050 26771-26780 Protein denotes ubiquitin
T14049 26757-26762 Protein denotes TRAF6
T14048 26690-26695 Protein denotes RANKL
T14047 26630-26634 Protein denotes CYLD
T14046 26559-26564 Protein denotes RANKL
T14045 26420-26424 Protein denotes CYLD
T14044 26333-26337 Protein denotes RANK
T14043 26290-26294 Protein denotes CYLD
T14042 26143-26147 Protein denotes CYLD
T14041 25985-25988 Protein denotes A20
T14040 25948-25952 Protein denotes CYLD
T14039 25933-25936 Protein denotes A20
T14038 25884-25887 Protein denotes A20
T14037 25843-25847 Protein denotes TAK1
T14036 25834-25838 Protein denotes RIP1
T14035 25827-25832 Protein denotes TRAF7
T14034 25820-25825 Protein denotes TRAF6
T14033 25813-25818 Protein denotes TRAF2
T14032 25807-25811 Protein denotes NEMO
T14031 25674-25678 Protein denotes RANK
T14030 25588-25611 Protein denotes deubiquitinating enzyme
T14029 25578-25582 Protein denotes CYLD
T14028 25385-25389 Protein denotes CYLD
T14027 25279-25283 Protein denotes CYLD
T14026 25262-25277 Protein denotes Cylindromatosis
T14025 25238-25253 Protein denotes Cylindromatosis
T12563 24568-24574 Regulation denotes effect
T12562 24482-24492 Gene_expression denotes expression
T12561 24208-24212 Regulation denotes role
T12560 24143-24147 Transcription denotes mRNA
T12559 24121-24125 Positive_regulation denotes high
T12558 24080-24087 Positive_regulation denotes induced
T12557 23922-23931 Negative_regulation denotes deficient
T12556 23874-23882 Negative_regulation denotes inhibits
T12555 23790-23797 Negative_regulation denotes lacking
T12554 23752-23759 Gene_expression denotes express
T12553 23717-23726 Gene_expression denotes expressed
T12552 23523-23532 Negative_regulation denotes deficient
T12551 23502-23511 Negative_regulation denotes deficient
T12550 23370-23374 Regulation denotes role
T12549 23315-23325 Gene_expression denotes expression
T12548 23229-23235 Binding denotes target
T12547 23128-23142 Positive_regulation denotes overexpression
T12546 23066-23076 Positive_regulation denotes activation
T12545 23052-23059 Negative_regulation denotes inhibit
T12544 22999-23008 Gene_expression denotes expressed
T12543 24679-24685 Protein denotes ABIN-1
T12542 24537-24540 Protein denotes A20
T12541 24526-24532 Protein denotes ABIN-3
T12540 24239-24242 Protein denotes A20
T12539 24217-24223 Protein denotes ABIN-1
T12538 24136-24142 Protein denotes ABIN-1
T12537 24076-24079 Protein denotes TNF
T12536 24048-24054 Protein denotes ABIN-1
T12535 23962-23965 Protein denotes TNF
T12534 23915-23921 Protein denotes ABIN-1
T12533 23883-23886 Protein denotes TNF
T12532 23853-23859 Protein denotes ABIN-1
T12531 23848-23851 Protein denotes A20
T12530 23762-23789 Protein denotes truncated and inactive form
T12529 23707-23713 Protein denotes ABIN-3
T12528 23516-23522 Protein denotes ABIN-2
T12527 23495-23501 Protein denotes ABIN-1
T12526 23383-23386 Protein denotes A20
T12525 23308-23314 Protein denotes ABIN-3
T12524 23297-23303 Protein denotes ABIN-1
T12523 23292-23295 Protein denotes A20
T12522 23236-23239 Protein denotes A20
T12521 23080-23083 Protein denotes TNF
T12520 23009-23012 Protein denotes A20
T12519 22959-22965 Protein denotes TNIP-3
T12518 22947-22953 Protein denotes TNIP-2
T12517 22939-22945 Protein denotes TNIP-1
T12516 22917-22923 Protein denotes ABIN-3
T12515 22906-22912 Protein denotes ABIN-2
T12514 22898-22904 Protein denotes ABIN-1
T12513 22866-22869 Protein denotes A20
T9496 22545-22554 Negative_regulation denotes repressed
T9495 21456-21460 Negative_regulation denotes lack
T9494 20970-20979 Negative_regulation denotes decreased
T9493 20888-20895 Positive_regulation denotes mediate
T9492 20586-20595 Negative_regulation denotes decreased
T9491 20503-20513 Gene_expression denotes expression
T9490 20275-20285 Gene_expression denotes expressing
T9489 20131-20140 Regulation denotes regulated
T9488 20110-20120 Gene_expression denotes expression
T9487 19933-19943 Gene_expression denotes expression
T9486 19790-19797 Negative_regulation denotes lacking
T9485 19475-19482 Negative_regulation denotes lacking
T9484 19315-19324 Negative_regulation denotes deficient
T9483 19130-19139 Negative_regulation denotes deficient
T9482 18850-18859 Negative_regulation denotes inhibitor
T9481 18738-18749 Binding denotes association
T9480 18512-18524 Binding denotes interactions
T9479 18498-18508 Negative_regulation denotes disruption
T9478 18451-18463 Binding denotes interactions
T9477 18417-18425 Negative_regulation denotes disrupts
T9476 22791-22794 Protein denotes A20
T9475 22555-22558 Protein denotes A20
T9474 22507-22510 Protein denotes A20
T9473 22327-22330 Protein denotes A20
T9472 22246-22249 Protein denotes A20
T9471 22208-22216 Protein denotes cytokine
T9470 22176-22179 Protein denotes TNF
T9469 22151-22154 Protein denotes TNF
T9468 22116-22119 Protein denotes A20
T9467 22029-22032 Protein denotes A20
T9466 21982-21985 Protein denotes A20
T9465 21828-21831 Protein denotes A20
T9464 21607-21610 Protein denotes A20
T9463 21461-21464 Protein denotes A20
T9462 21257-21260 Protein denotes A20
T9461 21162-21165 Protein denotes A20
T9460 21013-21016 Protein denotes A20
T9459 21004-21009 Protein denotes IL-1β
T9458 20996-20999 Protein denotes TNF
T9457 20869-20874 Protein denotes IL-1β
T9456 20861-20864 Protein denotes TNF
T9455 20703-20706 Protein denotes A20
T9454 20639-20674 Protein denotes monocyte chemo-attractant protein 1
T9453 20632-20637 Protein denotes RANKL
T9452 20618-20622 Protein denotes IL-6
T9451 20611-20616 Protein denotes IL-1β
T9450 20606-20609 Protein denotes TNF
T9449 20499-20502 Protein denotes A20
T9448 20271-20274 Protein denotes A20
T9447 20168-20171 Protein denotes A20
T9446 20106-20109 Protein denotes A20
T9445 19929-19932 Protein denotes A20
T9444 19798-19801 Protein denotes A20
T9443 19677-19680 Protein denotes A20
T9442 19643-19646 Protein denotes TNF
T9441 19483-19486 Protein denotes A20
T9440 19360-19363 Protein denotes TNF
T9439 19311-19314 Protein denotes A20
T9438 19126-19129 Protein denotes A20
T9437 19062-19065 Protein denotes A20
T9436 18964-18967 Protein denotes A20
T9435 18882-18904 Protein denotes Tax1-binding protein 1
T9434 18838-18877 Protein denotes A20-binding inhibitor of NF-κB (ABIN) 1
T9433 18753-18756 Protein denotes A20
T9432 18691-18694 Protein denotes A20
T9431 18634-18635 Protein denotes 2
T9430 18628-18633 Protein denotes cIAP1
T9429 18618-18623 Protein denotes TRAF2
T9428 18611-18616 Protein denotes TRAF6
T9427 18577-18583 Protein denotes Ubc5hc
T9426 18567-18572 Protein denotes Ubc13
T9425 18404-18409 Protein denotes MALT1
T9424 18394-18399 Protein denotes TRAF6
T9423 18388-18392 Protein denotes RIP2
T9422 18382-18386 Protein denotes RIP1
T9421 18275-18278 Protein denotes A20
T9420 18132-18135 Protein denotes TNF
T9419 18038-18043 Protein denotes NF-κB
T9418 17986-18011 Protein denotes ubiquitin-editing protein
T9417 17972-17979 Protein denotes TNFAIP3
T9416 17953-17956 Protein denotes A20
T9415 17941-17944 Protein denotes A20
T8347 17462-17473 Protein_catabolism denotes degradation
T8346 17428-17436 Positive_regulation denotes enhanced
T8345 17333-17343 Gene_expression denotes expressing
T8344 17302-17311 Negative_regulation denotes deficient
T8343 17781-17785 Protein denotes IKK1
T8342 17680-17683 Protein denotes NIK
T8341 17660-17664 Protein denotes IKK1
T8340 17596-17601 Protein denotes STAT1
T8339 17480-17484 Protein denotes IKK1
T8338 17457-17461 Protein denotes IκBα
T8337 17437-17441 Protein denotes IKK2
T8336 17353-17357 Protein denotes IKK1
T8335 17297-17301 Protein denotes IKK1
T8334 17069-17073 Protein denotes IKK1
T8333 16915-16921 Protein denotes TOLLIP
T8332 16903-16909 Protein denotes IRAK-M
T8331 16895-16901 Protein denotes MyD88s
T3983 15785-15795 Gene_expression denotes production
T3982 15752-15760 Positive_regulation denotes mediated
T3981 15734-15742 Positive_regulation denotes required
T3980 15469-15480 Protein_catabolism denotes proteolysis
T3979 15456-15461 Positive_regulation denotes leads
T3978 15362-15370 Binding denotes interact
T3977 15323-15330 Binding denotes binding
T3976 13803-13818 Phosphorylation denotes phosphorylation
T3975 13751-13762 Protein_catabolism denotes degradation
T3974 13678-13689 Protein_catabolism denotes degradation
T3973 13457-13468 Protein_catabolism denotes degradation
T3972 13227-13241 Protein_modification denotes -translational
T3971 13206-13215 Regulation denotes regulated
T3970 13137-13152 Phosphorylation denotes phosphorylation
T3969 12588-12596 Positive_regulation denotes activate
T3968 12556-12567 Binding denotes interaction
T3967 12509-12517 Binding denotes recruits
T3966 12465-12483 Negative_regulation denotes selfubiquitination
T3965 12311-12319 Positive_regulation denotes inducing
T3964 12045-12056 Binding denotes recruitment
T3963 12033-12040 Positive_regulation denotes induces
T3962 11498-11505 Binding denotes binding
T3961 11488-11498 Entity denotes ubiquitin-
T3960 11447-11454 Binding denotes recruit
T3959 11197-11202 Binding denotes bound
T3958 11071-11075 Binding denotes bind
T3957 10826-10837 Binding denotes recruitment
T3956 8180-8191 Protein_catabolism denotes degradation
T3955 8092-8107 Phosphorylation denotes phosphorylation
T3954 7344-7354 Negative_regulation denotes inhibitors
T3953 7193-7206 Localization denotes translocation
T3952 7185-7192 Entity denotes nuclear
T3951 7171-7178 Negative_regulation denotes prevent
T3950 15890-15894 Protein denotes CD40
T3949 15850-15855 Protein denotes TRAF3
T3948 15803-15808 Protein denotes TRAF2
T3947 15780-15784 Protein denotes IL-6
T3946 15747-15751 Protein denotes CD40
T3945 15725-15730 Protein denotes TRAF6
T3944 15676-15680 Protein denotes CD40
T3943 15499-15504 Protein denotes TRAF3
T3942 15489-15494 Protein denotes TRAF2
T3941 15440-15445 Protein denotes TRAF6
T3940 15429-15434 Protein denotes TRAF5
T3939 15422-15427 Protein denotes TRAF3
T3938 15415-15420 Protein denotes TRAF2
T3937 15408-15413 Protein denotes TRAF1
T3936 15357-15361 Protein denotes RANK
T3935 15348-15352 Protein denotes CD40
T3934 15228-15232 Protein denotes RANK
T3933 15201-15223 Protein denotes lymphotoxin β receptor
T3932 15195-15199 Protein denotes CD40
T3931 13798-13802 Protein denotes IKK1
T3930 13777-13780 Protein denotes NIK
T3929 13725-13728 Protein denotes NIK
T3928 13672-13677 Protein denotes TRAF3
T3927 13634-13635 Protein denotes 2
T3926 13628-13633 Protein denotes cIAP1
T3925 13618-13623 Protein denotes TRAF2
T3924 13540-13545 Protein denotes TRAF3
T3923 13426-13429 Protein denotes NIK
T3922 13395-13396 Protein denotes 2
T3921 13389-13394 Protein denotes cIAP1
T3920 13378-13383 Protein denotes TRAF3
T3919 13371-13376 Protein denotes TRAF2
T3918 13330-13333 Protein denotes NIK
T3903 12518-12523 Protein denotes TRAF6
T3902 12499-12503 Protein denotes TRIF
T3901 12487-12492 Protein denotes TRAF6
T3900 12427-12432 Protein denotes TRAF6
T3899 12347-12352 Protein denotes MyD88
T3898 12326-12330 Protein denotes TRIF
T3897 12281-12324 Protein denotes TIR domain-containing adaptor-inducing IFNβ
T3896 12270-12275 Protein denotes MyD88
T3895 12220-12268 Protein denotes myeloid differentiation primary response gene 88
T3894 12156-12160 Protein denotes TRAM
T3893 12125-12154 Protein denotes TRIF-related adaptor molecule
T3892 12116-12118 Protein denotes Ma
T3891 12060-12094 Protein denotes Toll/IL-1 receptor adaptor protein
T3890 11994-11998 Protein denotes TLR4
T3889 11906-11910 Protein denotes TAK1
T3888 11680-11683 Protein denotes TNF
T3887 11621-11625 Protein denotes NEMO
T3886 11529-11530 Protein denotes 2
T3885 11524-11528 Protein denotes TAB1
T3884 11515-11519 Protein denotes NEMO
T3883 11467-11471 Protein denotes TAK1
T3882 11405-11409 Protein denotes RIP1
T3881 11308-11312 Protein denotes RIP1
T3880 11282-11283 Protein denotes 2
T3879 11276-11281 Protein denotes cIAP1
T3878 11270-11271 Protein denotes 5
T3877 11264-11269 Protein denotes TRAF2
T3876 11203-11207 Protein denotes RIP1
T3875 11167-11170 Protein denotes TNF
T3874 11146-11151 Protein denotes cIAP2
T3873 11101-11141 Protein denotes cellular inhibitor of apoptosis (cIAP) 1
T3872 11050-11055 Protein denotes TRAF5
T3871 11006-11045 Protein denotes TNF receptor-associated factor (TRAF) 2
T3870 10935-10939 Protein denotes RIP1
T3869 10903-10933 Protein denotes receptor interacting protein 1
T3868 10881-10886 Protein denotes TRADD
T3867 10841-10879 Protein denotes TNF receptor-1-associated death domain
T3866 10795-10798 Protein denotes TNF
T3865 10782-10785 Protein denotes TNF
T3864 8474-8478 Protein denotes IKK1
T3863 8460-8464 Protein denotes NEMO
T3862 8451-8455 Protein denotes IKK2
T3861 8394-8398 Protein denotes IKKγ
T3860 8373-8377 Protein denotes NEMO
T3859 8346-8371 Protein denotes NF-κB essential modulator
T3858 8313-8317 Protein denotes IKKβ
T3857 8304-8308 Protein denotes IKKα
T3856 8284-8288 Protein denotes IKK2
T3855 8275-8279 Protein denotes IKK1
T3854 7830-7835 Protein denotes RANKL
T3853 7808-7811 Protein denotes TNF
T3852 7481-7484 Protein denotes p50
T3851 7473-7476 Protein denotes p52
T3850 7446-7450 Protein denotes p105
T3849 7437-7441 Protein denotes p100
T3848 7374-7379 Protein denotes Bcl-3
T3847 7365-7369 Protein denotes IκBξ
T3846 7326-7332 Protein denotes NF-κB2
T3845 7306-7310 Protein denotes p100
T3844 7297-7303 Protein denotes NF-κB1
T3843 7277-7281 Protein denotes p105
T3842 7271-7275 Protein denotes IκBε
T3841 7265-7269 Protein denotes IκBβ
T3840 7259-7263 Protein denotes IκBα
T3917 13185-13188 Protein denotes NIK
T3916 13179-13182 Protein denotes NIK
T3915 13156-13177 Protein denotes NF-κB inducing kinase
T3914 13107-13111 Protein denotes IKK1
T3913 12892-12896 Protein denotes RelB
T3912 12863-12866 Protein denotes p52
T3911 12824-12828 Protein denotes p100
T3910 12790-12794 Protein denotes RANK
T3909 12780-12784 Protein denotes CD40
T3908 12765-12778 Protein denotes BAFF receptor
T3907 12741-12763 Protein denotes lymphotoxin β receptor
T3906 12662-12665 Protein denotes TNF
T3905 12597-12601 Protein denotes TAK1
T3904 12533-12537 Protein denotes RIP1
T1679 6147-6156 Positive_regulation denotes increased
T1678 6032-6040 Localization denotes released
T1677 5995-6003 Localization denotes secreted
T1676 4882-4891 Gene_expression denotes producing
T1675 4765-4775 Gene_expression denotes expression
T1674 4756-4764 Positive_regulation denotes Enhanced
T1673 4264-4273 Gene_expression denotes expressed
T1672 4207-4214 Binding denotes Binding
T1671 4146-4157 Positive_regulation denotes upregulated
T1670 3967-3976 Gene_expression denotes expressed
T1669 6759-6769 Protein denotes tenascin C
T1668 6749-6757 Protein denotes biglycan
T1667 6736-6747 Protein denotes fibronectin
T1666 6565-6569 Protein denotes TLR4
T1665 6341-6367 Protein denotes myeloid-related protein 14
T1664 6311-6336 Protein denotes Myeloid-related protein 8
T1663 6248-6253 Protein denotes HMGB1
T1662 6183-6188 Protein denotes HMGB1
T1661 6138-6143 Protein denotes HMGB1
T1660 6099-6111 Protein denotes TLR4 ligands
T1659 5954-5973 Protein denotes chromatin component
T1658 5927-5932 Protein denotes HMGB1
T1657 5880-5925 Protein denotes High mobility group box chromosomal protein 1
T1656 5011-5033 Protein denotes lymphotoxin β receptor
T1655 4957-4961 Protein denotes BAFF
T1654 4836-4840 Protein denotes BAFF
T1653 4810-4834 Protein denotes B-cell activating factor
T1652 4576-4580 Protein denotes CD40
T1651 4302-4305 Protein denotes CD4
T1650 4235-4240 Protein denotes CD154
T1649 4222-4233 Protein denotes CD40 ligand
T1648 4197-4200 Protein denotes TNF
T1647 3919-3945 Protein denotes TNF receptor family member
T1646 3903-3907 Protein denotes CD40
T1645 3789-3793 Protein denotes RANK
T1644 3693-3697 Protein denotes RANK
T1643 3664-3691 Protein denotes receptor activator of NF-κB
T1642 3450-3453 Protein denotes TNF
T1641 3375-3378 Protein denotes TNF
T1640 3316-3319 Protein denotes TNF
T280 2869-2880 Binding denotes association
T279 1836-1846 Gene_expression denotes expression
T278 1823-1831 Regulation denotes regulate
T277 2966-2971 Protein denotes c-REL
T276 2953-2960 Protein denotes TNFAIP3
T275 2946-2951 Protein denotes TRAF1
T274 2940-2944 Protein denotes CD40
T273 2690-2695 Protein denotes RANKL
T272 2654-2688 Protein denotes receptor activator of NF-κB ligand
T271 2035-2038 Protein denotes TNF
T270 1932-1963 Protein denotes inducible nitric oxide synthase
T269 1901-1918 Protein denotes cyclo-oxygenase-2
T268 1895-1899 Protein denotes IL-6
T267 1884-1887 Protein denotes TNF
T266 1758-1763 Protein denotes c-Rel
T265 1752-1756 Protein denotes RelB
T264 1746-1750 Protein denotes RelA
T263 1739-1742 Protein denotes p65
T262 1731-1737 Protein denotes NF-κB1
T261 1723-1727 Protein denotes p105
T260 1715-1721 Protein denotes NF-κB2
T259 1707-1711 Protein denotes p100
R206 T261 T278 causeOf p105,regulate
R207 T264 T278 causeOf RelA,regulate
R208 T265 T278 causeOf RelB,regulate
R209 T266 T278 causeOf c-Rel,regulate
R210 T267 T279 themeOf TNF,expression
R211 T268 T279 themeOf IL-6,expression
R212 T269 T279 themeOf cyclo-oxygenase-2,expression
R213 T270 T279 themeOf inducible nitric oxide synthase,expression
R214 T273 T272 equivalentTo RANKL,receptor activator of NF-κB ligand
R215 T274 T280 themeOf CD40,association
R216 T275 T280 themeOf TRAF1,association
R217 T276 T280 themeOf TNFAIP3,association
R218 T277 T280 themeOf c-REL,association
R219 T279 T278 themeOf expression,regulate
R1266 T1644 T1643 equivalentTo RANK,receptor activator of NF-κB
R1267 T1646 T1670 themeOf CD40,expressed
R1268 T1647 T1670 themeOf TNF receptor family member,expressed
R1269 T1648 T1671 causeOf TNF,upregulated
R1270 T1649 T1672 themeOf CD40 ligand,Binding
R1271 T1649 T1673 themeOf CD40 ligand,expressed
R1272 T1650 T1649 equivalentTo CD154,CD40 ligand
R1273 T1653 T1675 themeOf B-cell activating factor,expression
R1274 T1654 T1653 equivalentTo BAFF,B-cell activating factor
R1275 T1657 T1659 themeOf High mobility group box chromosomal protein 1,chromatin component
R1276 T1657 T1678 themeOf High mobility group box chromosomal protein 1,released
R1277 T1657 T1677 themeOf High mobility group box chromosomal protein 1,secreted
R1278 T1658 T1657 equivalentTo HMGB1,High mobility group box chromosomal protein 1
R1279 T1659 T1677 themeOf chromatin component,secreted
R1280 T1661 T1679 themeOf HMGB1,increased
R1281 T1670 T1671 themeOf expressed,upregulated
R2776 T3847 T3954 themeOf IκBξ,inhibitors
R2777 T3848 T3954 themeOf Bcl-3,inhibitors
R2778 T3867 T3957 themeOf TNF receptor-1-associated death domain,recruitment
R2779 T3868 T3867 equivalentTo TRADD,TNF receptor-1-associated death domain
R2780 T3869 T3957 themeOf receptor interacting protein 1,recruitment
R2781 T3870 T3867 equivalentTo RIP1,TNF receptor-1-associated death domain
R2782 T3870 T3869 equivalentTo RIP1,receptor interacting protein 1
R2783 T3871 T3958 themeOf TNF receptor-associated factor (TRAF) 2,bind
R2784 T3872 T3958 themeOf TRAF5,bind
R2785 T3873 T3958 themeOf cellular inhibitor of apoptosis (cIAP) 1,bind
R2786 T3874 T3958 themeOf cIAP2,bind
R2787 T3876 T3959 themeOf RIP1,bound
R2788 T3883 T3960 themeOf TAK1,recruit
R2789 T3890 T3963 causeOf TLR4,induces
R2790 T3891 T3964 themeOf Toll/IL-1 receptor adaptor protein,recruitment
R2791 T3893 T3964 themeOf TRIF-related adaptor molecule,recruitment
R2792 T3894 T3893 equivalentTo TRAM,TRIF-related adaptor molecule
R2793 T3896 T3895 equivalentTo MyD88,myeloid differentiation primary response gene 88
R2794 T3898 T3897 equivalentTo TRIF,TIR domain-containing adaptor-inducing IFNβ
R2795 T3901 T3966 themeOf TRAF6,selfubiquitination
R2796 T3902 T3968 themeOf TRIF,interaction
R2797 T3902 T3967 themeOf TRIF,recruits
R2798 T3903 T3968 themeOf TRAF6,interaction
R2799 T3903 T3967 themeOf TRAF6,recruits
R2800 T3904 T3968 themeOf RIP1,interaction
R2801 T3904 T3967 themeOf RIP1,recruits
R2802 T3905 T3969 themeOf TAK1,activate
R2803 T3911 T3970 themeOf p100,phosphorylation
R2804 T3915 T3970 causeOf NF-κB inducing kinase,phosphorylation
R2805 T3916 T3915 equivalentTo NIK,NF-κB inducing kinase
R2806 T3918 T3973 themeOf NIK,degradation
R2807 T3919 T3973 themeOf TRAF2,degradation
R2808 T3920 T3973 themeOf TRAF3,degradation
R2809 T3921 T3973 themeOf cIAP1,degradation
R2810 T3922 T3973 themeOf 2,degradation
R2811 T3923 T3973 themeOf NIK,degradation
R2812 T3928 T3974 themeOf TRAF3,degradation
R2813 T3931 T3976 themeOf IKK1,phosphorylation
R2814 T3935 T3978 themeOf CD40,interact
R2815 T3935 T3977 themeOf CD40,binding
R2816 T3936 T3978 themeOf RANK,interact
R2817 T3937 T3978 themeOf TRAF1,interact
R2818 T3938 T3977 themeOf TRAF2,binding
R2819 T3938 T3978 themeOf TRAF2,interact
R2820 T3939 T3977 themeOf TRAF3,binding
R2821 T3939 T3978 themeOf TRAF3,interact
R2822 T3940 T3978 themeOf TRAF5,interact
R2823 T3940 T3977 themeOf TRAF5,binding
R2824 T3941 T3977 themeOf TRAF6,binding
R2825 T3941 T3978 themeOf TRAF6,interact
R2826 T3942 T3980 themeOf TRAF2,proteolysis
R2827 T3943 T3980 themeOf TRAF3,proteolysis
R2828 T3945 T3981 causeOf TRAF6,required
R2829 T3946 T3982 causeOf CD40,mediated
R2830 T3947 T3983 themeOf IL-6,production
R2831 T3952 T3953 locationOf nuclear,translocation
R2832 T3953 T3951 themeOf translocation,prevent
R2833 T3961 T3962 themeOf ubiquitin-,binding
R2834 T3964 T3963 themeOf recruitment,induces
R2835 T3972 T3971 themeOf -translational,regulated
R2836 T3977 T3979 causeOf binding,leads
R2837 T3978 T3979 causeOf interact,leads
R2838 T3980 T3979 themeOf proteolysis,leads
R2839 T3982 T3981 themeOf mediated,required
R2840 T3983 T3982 themeOf production,mediated
R5567 T8335 T8344 themeOf IKK1,deficient
R5568 T8336 T8345 themeOf IKK1,expressing
R5569 T8338 T8347 themeOf IκBα,degradation
R5570 T8347 T8346 themeOf degradation,enhanced
R6327 T9421 T9477 causeOf A20,disrupts
R6328 T9423 T9477 causeOf RIP2,disrupts
R6329 T9424 T9477 causeOf TRAF6,disrupts
R6330 T9425 T9477 causeOf MALT1,disrupts
R6331 T9427 T9480 themeOf Ubc5hc,interactions
R6332 T9429 T9480 themeOf TRAF2,interactions
R6333 T9430 T9480 themeOf cIAP1,interactions
R6334 T9431 T9480 themeOf 2,interactions
R6335 T9433 T9481 themeOf A20,association
R6336 T9435 T9482 themeOf Tax1-binding protein 1,inhibitor
R6337 T9438 T9483 themeOf A20,deficient
R6338 T9439 T9484 themeOf A20,deficient
R6339 T9441 T9485 themeOf A20,lacking
R6340 T9444 T9486 themeOf A20,lacking
R6341 T9445 T9487 themeOf A20,expression
R6342 T9446 T9488 themeOf A20,expression
R6343 T9447 T9489 causeOf A20,regulated
R6344 T9448 T9490 themeOf A20,expressing
R6345 T9449 T9491 themeOf A20,expression
R6346 T9450 T9492 themeOf TNF,decreased
R6347 T9451 T9492 themeOf IL-1β,decreased
R6348 T9452 T9492 themeOf IL-6,decreased
R6349 T9453 T9492 themeOf RANKL,decreased
R6350 T9454 T9492 themeOf monocyte chemo-attractant protein 1,decreased
R6351 T9456 T9493 causeOf TNF,mediate
R6352 T9457 T9493 causeOf IL-1β,mediate
R6353 T9458 T9494 themeOf TNF,decreased
R6354 T9459 T9494 themeOf IL-1β,decreased
R6355 T9463 T9495 themeOf A20,lack
R6356 T9478 T9477 themeOf interactions,disrupts
R6357 T9480 T9479 themeOf interactions,disruption
R6358 T9488 T9489 themeOf expression,regulated
R8292 T12514 T12545 causeOf ABIN-1,inhibit
R8293 T12514 T12544 themeOf ABIN-1,expressed
R8294 T12514 T12547 themeOf ABIN-1,overexpression
R8295 T12515 T12544 themeOf ABIN-2,expressed
R8296 T12516 T12544 themeOf ABIN-3,expressed
R8297 T12517 T12544 themeOf TNIP-1,expressed
R8298 T12518 T12544 themeOf TNIP-2,expressed
R8299 T12520 T12544 themeOf A20,expressed
R8300 T12521 T12546 causeOf TNF,activation
R8301 T12522 T12548 themeOf A20,target
R8302 T12523 T12549 themeOf A20,expression
R8303 T12524 T12549 themeOf ABIN-1,expression
R8304 T12525 T12549 themeOf ABIN-3,expression
R8305 T12527 T12551 themeOf ABIN-1,deficient
R8306 T12527 T12552 themeOf ABIN-1,deficient
R8307 T12528 T12552 themeOf ABIN-2,deficient
R8308 T12529 T12554 themeOf ABIN-3,express
R8309 T12529 T12553 themeOf ABIN-3,expressed
R8310 T12532 T12556 causeOf ABIN-1,inhibits
R8311 T12534 T12557 themeOf ABIN-1,deficient
R8312 T12537 T12558 causeOf TNF,induced
R8313 T12541 T12562 themeOf ABIN-3,expression
R8314 T12542 T12562 themeOf A20,expression
R8315 T12546 T12545 themeOf activation,inhibit
R9294 T14027 T14026 equivalentTo CYLD,Cylindromatosis
R9295 T14041 T14059 themeOf A20,expressed
R9296 T14047 T14061 themeOf CYLD,expression
R9297 T14049 T14063 themeOf TRAF6,recruited
R9298 T14052 T14063 themeOf sequestosome 1,recruited
R9299 T14052 T14064 causeOf sequestosome 1,via
R9300 T14063 T14064 themeOf recruited,via
R10157 T15421 T15420 equivalentTo SIGIRR,Single-immunoglobulin IL-1 receptor-related
R10158 T15423 T15436 themeOf IL-1R,inhibitor
R10159 T15423 T15437 themeOf IL-1R,interaction
R10160 T15424 T15437 themeOf MyD88,interaction
R10161 T15425 T15437 themeOf IRAK1,interaction
R10162 T15426 T15437 themeOf TRAF6,interaction
R10163 T15429 T15438 themeOf SIGIRR,expressed
R10164 T15432 T15439 themeOf SIGIRR,deficient
R10165 T15433 T15440 themeOf SIGIRR,expression
R10166 T15435 T15442 themeOf SIGIRR,expression
R10748 T16289 T16306 themeOf TRAF1,Expression
R10749 T16290 T16307 causeOf TNF,inducible
R10750 T16291 T16308 themeOf TRAF1,overexpression
R10751 T16293 T16310 themeOf TRAF1,deficient
R10752 T16297 T16311 themeOf TRAF1,deficient
R10753 T16300 T16312 themeOf TRAF1,binding
R10754 T16301 T16314 themeOf TRAF1,interact
R10755 T16301 T16313 themeOf TRAF1,recruit
R10756 T16302 T16313 themeOf A20,recruit
R10757 T16302 T16314 themeOf A20,interact
R10758 T16306 T16307 themeOf Expression,inducible
R11370 T17316 T17347 themeOf miR-146a,induced
R11371 T17318 T17347 themeOf miR-155,induced
R11372 T17319 T17347 causeOf IL-1β,induced
R11373 T17320 T17347 causeOf TNF,induced
R11374 T17325 T17348 themeOf miR-155,target
R11375 T17326 T17348 themeOf IKKε,target
R11376 T17327 T17348 themeOf RIP1,target
R11377 T17328 T17349 themeOf miR-155,expressed
R11378 T17329 T17350 themeOf miR-146a,overexpressed
R11379 T17331 T17351 themeOf IL-17,producing
R11380 T17333 T17352 themeOf miR-155,overexpression
R11381 T17334 T17354 causeOf miR-155,promote
R11382 T17335 T17355 themeOf TNF,production
R11383 T17338 T17357 causeOf miR-124a,regulator
R11384 T17339 T17357 themeOf monocyte chemoattractant protein 1,regulator
R11385 T17341 T17360 themeOf matrix metalloproteinase-1,secretion
R11386 T17342 T17360 themeOf IL-6,secretion
R11387 T17343 T17361 themeOf miR-16,expression
R11388 T17344 T17361 themeOf miR-132,expression
R11389 T17345 T17361 themeOf miR-223,expression
R11390 T17355 T17354 themeOf production,promote
R11391 T17360 T17359 themeOf secretion,increased
R12749 T19260 T19316 themeOf TNFR1,engagement
R12750 T19261 T19316 themeOf CD40,engagement
R12751 T19262 T19316 themeOf RANK,engagement
R12752 T19263 T19317 causeOf TLR4,trigger
R12753 T19263 T19316 themeOf TLR4,engagement
R12754 T19264 T19318 themeOf TNF receptor 1-associated death domain protein,recruitment
R12755 T19266 T19318 themeOf MyD88,recruitment
R12756 T19267 T19318 themeOf MAL,recruitment
R12757 T19268 T19318 themeOf TIR domain-containing adaptor-inducing IFNβ,recruitment
R12758 T19269 T19268 equivalentTo TRIF,TIR domain-containing adaptor-inducing IFNβ
R12759 T19270 T19268 equivalentTo RIP1,TIR domain-containing adaptor-inducing IFNβ
R12760 T19271 T19318 themeOf IRAK1,recruitment
R12761 T19272 T19318 themeOf IRAK4,recruitment
R12762 T19273 T19268 equivalentTo TRAF2,TIR domain-containing adaptor-inducing IFNβ
R12763 T19274 T19318 themeOf TRAF6,recruitment
R12764 T19275 T19318 themeOf cIAP1,recruitment
R12765 T19276 T19318 themeOf cIAP2,recruitment
R12766 T19283 T19321 themeOf IKK2,degradation
R12767 T19284 T19320 themeOf IκBα,phosphorylates
R12768 T19285 T19322 themeOf p65,translocate
R12769 T19286 T19322 themeOf p50,translocate
R12770 T19290 T19324 themeOf RIP1,recruited
R12771 T19291 T19324 themeOf TRAF6,recruited
R12772 T19292 T19324 themeOf ABIN-1,recruited
R12773 T19293 T19324 themeOf p62,recruited
R12774 T19294 T19327 themeOf IRAK1,expression
R12775 T19295 T19327 themeOf TRAF6,expression
R12776 T19296 T19328 causeOf SIGIRR,inhibited
R12777 T19297 T19330 themeOf TLR4,binding
R12778 T19298 T19330 themeOf IRAK1,binding
R12779 T19299 T19330 themeOf TRAF6,binding
R12780 T19304 T19331 themeOf MyD88,inhibitor
R12781 T19305 T19331 themeOf myeloid differentiation primary response gene 88,inhibitor
R12782 T19306 T19331 themeOf NEMO,inhibitor
R12783 T19307 T19331 themeOf NF-κB essential modulator,inhibitor
R12784 T19308 T19331 themeOf RANK,inhibitor
R12785 T19309 T19331 themeOf receptor activator of NF-κB,inhibitor
R12786 T19309 T19308 themeOf receptor activator of NF-κB,RANK
R12787 T19310 T19331 themeOf RIP1,inhibitor
R12788 T19311 T19331 themeOf receptor interacting protein 1,inhibitor
R12789 T19312 T19331 themeOf SIGIRR,inhibitor
R12790 T19313 T19331 themeOf single-immunoglobulinIL-1 receptor-related,inhibitor
R12791 T19314 T19308 themeOf TNF,RANK
R12792 T19314 T19331 themeOf TNF,inhibitor
R12793 T19315 T19331 themeOf tumour necrosis factor,inhibitor
R12794 T19318 T19317 themeOf recruitment,trigger
R12795 T19319 T19317 themeOf inducing,trigger
R12796 T19323 T19322 locationOf nucleus,translocate
R12797 T19327 T19326 themeOf expression,inhibiting
R12798 T19330 T19329 themeOf binding,compete
R13906 T21285 T21317 themeOf NF-κB inducing kinase,expression
R13907 T21286 T21285 equivalentTo NIK,NF-κB inducing kinase
R13908 T21292 T21318 themeOf NIK,degradation
R13909 T21294 T21319 themeOf TRAF3,recruited
R13910 T21304 T21320 themeOf NIK,increased
R13911 T21305 T21321 themeOf NIK,phosphorylates
R13912 T21306 T21321 themeOf IKK1,phosphorylates
R13913 T21306 T21322 causeOf IKK1,mediates
R13914 T21307 T21323 themeOf p100,phosphorylation
R13915 T21308 T21324 themeOf p100,degradation
R13916 T21309 T21324 themeOf p52,degradation
R13917 T21323 T21322 themeOf phosphorylation,mediates

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T114 0-8 JJ denotes Negative
T115 9-19 NN denotes regulation
T116 20-22 IN denotes of
T117 23-28 NNP denotes NF-κB
T118 29-32 CC denotes and
T119 33-36 PRP$ denotes its
T120 37-48 NN denotes involvement
T121 49-51 IN denotes in
T122 52-62 JJ denotes rheumatoid
T123 63-72 NNS denotes arthritis
T22073 15165-15166 . denotes .
T22072 15159-15165 NN denotes factor
T22071 15150-15158 NN denotes necrosis
T22070 15143-15149 NN denotes tumour
T22069 15141-15142 , denotes ,
T22068 15138-15141 NNP denotes TNF
T22067 15136-15137 : denotes ;
T22066 15130-15136 NN denotes factor
T22065 15110-15129 VBD denotes receptor-associated
T22064 15106-15109 NNP denotes TNF
T22063 15104-15105 , denotes ,
T22062 15100-15104 NNP denotes TRAF
T22061 15098-15099 : denotes ;
T22060 15093-15098 NN denotes NF-κB
T22059 15090-15092 IN denotes of
T22058 15080-15089 NN denotes activator
T22057 15071-15079 NN denotes receptor
T22056 15069-15070 , denotes ,
T22055 15065-15069 NNP denotes RANK
T22054 15063-15064 : denotes ;
T22053 15057-15063 NN denotes factor
T22052 15049-15056 JJ denotes nuclear
T22051 15047-15048 , denotes ,
T22050 15045-15047 NNP denotes NF
T22049 15043-15044 : denotes ;
T22048 15037-15043 NN denotes kinase
T22047 15033-15036 NNP denotes IκB
T22046 15031-15032 , denotes ,
T22045 15028-15031 NNP denotes IKK
T22044 15026-15027 : denotes ;
T22043 15017-15026 NN denotes apoptosis
T22042 15014-15016 IN denotes of
T22041 15004-15013 NN denotes inhibitor
T22040 14995-15003 JJ denotes cellular
T22039 14993-14994 , denotes ,
T22038 14989-14993 NNP denotes cIAP
T22037 14987-14988 . denotes .
T22036 14980-14987 NNS denotes factors
T22035 14960-14979 JJ denotes receptor-associated
T22034 14956-14959 NNP denotes TNF
T22033 14950-14955 JJ denotes other
T22032 14945-14949 IN denotes with
T22031 14935-14944 VBG denotes competing
T22030 14932-14934 IN denotes by
T22029 14923-14931 RB denotes probably
T22028 14918-14922 JJS denotes most
T22027 14916-14917 , denotes ,
T22026 14909-14916 NN denotes pathway
T22025 14904-14908 DT denotes this
T22024 14901-14903 IN denotes of
T22023 14891-14900 NN denotes regulator
T22022 14882-14890 JJ denotes negative
T22021 14880-14881 DT denotes a
T22020 14877-14879 IN denotes as
T22019 14866-14876 VBN denotes identified
T22018 14861-14865 VBN denotes been
T22017 14856-14860 RB denotes also
T22016 14852-14855 VBZ denotes has
T22015 14846-14851 CD denotes TRAF1
T22014 14844-14845 , denotes ,
T22013 14839-14844 CD denotes TRAF3
T22012 14836-14838 TO denotes to
T22011 14831-14835 JJ denotes Next
T22010 14829-14830 . denotes .
T22009 14816-14829 NN denotes transcription
T22008 14807-14815 VB denotes activate
T22007 14804-14806 TO denotes to
T22006 14799-14803 NNP denotes RelB
T22005 14794-14798 IN denotes with
T22004 14782-14793 NN denotes heterodimer
T22003 14780-14781 DT denotes a
T22002 14774-14779 VBZ denotes forms
T22001 14768-14773 WDT denotes which
T22000 14766-14767 , denotes ,
T21999 14763-14766 CD denotes p52
T21998 14760-14762 TO denotes to
T21997 14755-14759 CD denotes p100
T21996 14752-14754 IN denotes of
T21995 14740-14751 NN denotes degradation
T21994 14728-14739 JJ denotes proteasomal
T21993 14720-14727 JJ denotes partial
T21992 14716-14719 CC denotes and
T21991 14697-14715 NN denotes polyubiquitination
T21990 14686-14696 JJ denotes K48-linked
T21989 14683-14685 IN denotes by
T21988 14674-14682 VBN denotes followed
T21987 14671-14673 VBZ denotes is
T21986 14666-14670 DT denotes This
T21985 14664-14665 . denotes .
T21984 14649-14664 NN denotes phosphorylation
T21983 14644-14648 CD denotes p100
T21982 14638-14643 NNP denotes NF-κB
T21981 14629-14637 VBZ denotes mediates
T21980 14623-14628 WDT denotes which
T21979 14621-14622 , denotes ,
T21978 14617-14621 NNP denotes IKK1
T21977 14607-14616 VBZ denotes activates
T21976 14603-14606 CC denotes and
T21975 14588-14602 VBZ denotes phosphorylates
T21974 14583-14587 RB denotes then
T21973 14579-14582 NNP denotes NIK
T21972 14577-14578 . denotes .
T21971 14573-14577 NN denotes cell
T21970 14569-14572 DT denotes the
T21969 14566-14568 IN denotes in
T21968 14559-14565 NNS denotes levels
T21967 14555-14558 NNP denotes NIK
T21966 14545-14554 VBN denotes increased
T21965 14542-14544 IN denotes in
T21964 14532-14541 VBG denotes resulting
T21963 14530-14531 , denotes ,
T21962 14520-14530 VBN denotes stabilised
T21961 14517-14519 VBZ denotes is
T21960 14513-14516 NNP denotes NIK
T21959 14509-14512 CC denotes and
T21958 14500-14508 JJ denotes degraded
T21957 14497-14499 VBZ denotes is
T21956 14491-14496 CD denotes TRAF3
T21955 14489-14490 , denotes ,
T21954 14483-14489 NN denotes result
T21953 14481-14482 DT denotes a
T21952 14478-14480 IN denotes As
T21951 14476-14477 . denotes .
T21950 14473-14476 NNP denotes NIK
T21949 14468-14472 IN denotes than
T21948 14461-14467 RB denotes rather
T21902 14144-14162 NN denotes polyubiquitination
T21901 14133-14143 JJ denotes K48-linked
T21900 14129-14132 DT denotes the
T21899 14117-14128 VBZ denotes facilitates
T21898 14111-14116 WDT denotes which
T21897 14109-14110 , denotes ,
T21896 14102-14109 NNP denotes cIAP1/2
T21895 14098-14101 CC denotes and
T21894 14092-14097 CD denotes TRAF3
T21893 14090-14091 , denotes ,
T21892 14085-14090 CD denotes TRAF2
T21891 14077-14084 VBZ denotes ligases
T21890 14067-14076 NN denotes ubiquitin
T21889 14063-14066 DT denotes the
T21888 14058-14062 IN denotes with
T21887 14050-14057 NN denotes complex
T21886 14040-14049 JJ denotes cytosolic
T21885 14038-14039 DT denotes a
T21884 14032-14037 VBZ denotes forms
T21883 14028-14031 NNP denotes NIK
T21882 14022-14027 NNS denotes cells
T21881 14009-14021 JJ denotes unstimulated
T21880 14006-14008 IN denotes In
T21879 14004-14005 . denotes .
T21878 13998-14004 NNS denotes levels
T21877 13987-13997 NN denotes expression
T21876 13985-13986 -RRB- denotes )
T21875 13982-13985 NNP denotes NIK
T21874 13981-13982 -LRB- denotes (
T21873 13974-13980 NN denotes kinase
T21872 13965-13973 VBG denotes inducing
T21871 13959-13964 JJ denotes NF-κB
T21870 13956-13958 IN denotes on
T21869 13946-13955 JJ denotes dependent
T21868 13943-13945 VBZ denotes is
T21867 13938-13942 WDT denotes that
T21866 13930-13937 NN denotes pathway
T21865 13924-13929 NN denotes NF-κB
T21864 13911-13923 JJ denotes noncanonical
T21863 13907-13910 DT denotes the
T21862 13898-13906 VB denotes activate
T21861 13894-13897 MD denotes can
T21860 13889-13893 NNP denotes RANK
T21859 13885-13888 CC denotes and
T21858 13880-13884 CD denotes CD40
T21857 13878-13879 . denotes .
T21856 13868-13878 VBG denotes signalling
T21855 13862-13867 NNP denotes NF-κB
T21854 13849-13861 NNP denotes Noncanonical
T20557 10723-10724 . denotes .
T20556 10717-10723 NN denotes factor
T20555 10708-10716 NN denotes necrosis
T20554 10701-10707 NN denotes tumour
T20553 10699-10700 , denotes ,
T20552 10696-10699 NNP denotes TNF
T20551 10694-10695 : denotes ;
T20550 10686-10694 NN denotes receptor
T20549 10676-10685 JJ denotes Toll-like
T20548 10674-10675 , denotes ,
T20547 10671-10674 NNP denotes TLR
T20546 10669-10670 : denotes ;
T20545 10663-10669 NN denotes factor
T20544 10643-10662 VBD denotes receptor-associated
T20543 10639-10642 NNP denotes TNF
T20542 10637-10638 , denotes ,
T20541 10633-10637 NNP denotes TRAF
T20540 10631-10632 : denotes ;
T20539 10630-10631 NN denotes R
T20538 10628-10630 CD denotes -1
T20537 10617-10628 NNP denotes receptor/IL
T20536 10607-10616 JJ denotes Toll-like
T20535 10605-10606 , denotes ,
T20534 10602-10605 NNP denotes TIR
T20533 10600-10601 : denotes ;
T20532 10584-10600 JJ denotes receptor-related
T20531 10558-10583 JJ denotes single-immunoglobulinIL-1
T20530 10556-10557 , denotes ,
T20529 10550-10556 NNP denotes SIGIRR
T20528 10548-10549 : denotes ;
T20527 10547-10548 CD denotes 1
T20526 10539-10546 NN denotes protein
T20525 10527-10538 VBG denotes interacting
T20524 10518-10526 NN denotes receptor
T20523 10516-10517 , denotes ,
T20522 10512-10516 NNP denotes RIP1
T20521 10510-10511 : denotes ;
T20520 10505-10510 NNP denotes NF-κB
T20519 10502-10504 IN denotes of
T20518 10492-10501 NN denotes activator
T20517 10483-10491 NN denotes receptor
T20516 10481-10482 , denotes ,
T20515 10477-10481 NNP denotes RANK
T20514 10475-10476 : denotes ;
T20513 10469-10475 NN denotes factor
T20512 10461-10468 JJ denotes nuclear
T20511 10459-10460 , denotes ,
T20510 10457-10459 NNP denotes NF
T20509 10455-10456 : denotes ;
T20508 10446-10455 NN denotes modulator
T20507 10436-10445 JJ denotes essential
T20506 10430-10435 NNP denotes NF-κB
T20505 10428-10429 , denotes ,
T20504 10424-10428 NNP denotes NEMO
T20503 10422-10423 : denotes ;
T20502 10420-10422 CD denotes 88
T20501 10415-10419 NN denotes gene
T20500 10406-10414 NN denotes response
T20499 10398-10405 JJ denotes primary
T20498 10382-10397 NN denotes differentiation
T20497 10374-10381 JJ denotes myeloid
T20496 10372-10373 , denotes ,
T20495 10367-10372 NNP denotes MyD88
T20494 10365-10366 : denotes ;
T20493 10359-10365 NN denotes kinase
T20492 10342-10358 JJ denotes IL-1R-associated
T20491 10340-10341 , denotes ,
T20490 10336-10340 NNP denotes IRAK
T20489 10334-10335 : denotes ;
T20488 10329-10334 NN denotes NF-κB
T20487 10326-10328 IN denotes of
T20486 10316-10325 NN denotes inhibitor
T20485 10314-10315 , denotes ,
T20484 10311-10314 NNP denotes IκB
T20483 10309-10310 : denotes ;
T20482 10303-10309 NN denotes kinase
T20481 10299-10302 NNP denotes IκB
T20480 10297-10298 , denotes ,
T20479 10294-10297 NNP denotes IKK
T20478 10292-10293 : denotes ;
T20477 10277-10292 NN denotes cylindromatosis
T20476 10275-10276 , denotes ,
T20475 10271-10275 NNP denotes CYLD
T20474 10269-10270 : denotes ;
T20473 10260-10269 NN denotes apoptosis
T20472 10257-10259 IN denotes of
T20471 10247-10256 NN denotes inhibitor
T20470 10238-10246 JJ denotes cellular
T20469 10236-10237 , denotes ,
T20468 10232-10236 NNP denotes cIAP
T20467 10230-10231 : denotes ;
T20466 10225-10230 NN denotes NF-κB
T20465 10222-10224 IN denotes of
T20464 10212-10221 NN denotes inhibitor
T20463 10200-10211 JJ denotes A20-binding
T20462 10198-10199 , denotes ,
T20461 10194-10198 NNP denotes ABIN
T20460 10192-10193 . denotes .
T20459 10182-10192 NN denotes activation
T20404 9861-9866 NNP denotes IRAK1
T20403 9858-9860 IN denotes of
T20402 9847-9857 NN denotes expression
T20401 9836-9846 VBG denotes inhibiting
T20400 9833-9835 IN denotes by
T20399 9822-9832 JJ denotes signalling
T20398 9818-9821 NNP denotes TLR
T20397 9809-9817 VB denotes regulate
T20396 9798-9808 RB denotes negatively
T20395 9795-9797 TO denotes to
T20394 9787-9794 VBN denotes thought
T20393 9784-9786 VBZ denotes is
T20392 9776-9783 NN denotes miR-146
T20391 9774-9775 . denotes .
T20390 9771-9774 CD denotes p62
T20389 9767-9770 CC denotes and
T20388 9760-9766 NNP denotes ABIN-1
T20387 9757-9759 IN denotes as
T20386 9752-9756 JJ denotes such
T20385 9743-9751 NNS denotes proteins
T20384 9735-9742 NN denotes adaptor
T20383 9717-9734 JJ denotes ubiquitin-binding
T20382 9708-9716 JJ denotes specific
T20381 9702-9707 VBG denotes using
T20380 9692-9701 VBN denotes recruited
T20379 9688-9691 VBP denotes are
T20378 9683-9687 PRP denotes they
T20377 9677-9682 WDT denotes which
T20376 9674-9676 TO denotes to
T20375 9672-9673 , denotes ,
T20374 9667-9672 NNP denotes TRAF6
T20373 9663-9666 CC denotes and
T20372 9658-9662 NNP denotes RIP1
T20371 9648-9657 VBG denotes including
T20370 9639-9647 NNS denotes proteins
T20369 9628-9638 VBG denotes signalling
T20368 9619-9627 JJ denotes specific
T20367 9609-9618 VBG denotes targeting
T20366 9606-9608 IN denotes by
T20365 9595-9605 NN denotes activation
T20364 9589-9594 JJ denotes NF-κB
T20363 9581-9588 VBP denotes control
T20362 9576-9580 WDT denotes that
T20361 9568-9575 NNS denotes enzymes
T20360 9551-9567 VBG denotes deubiquitinating
T20359 9547-9550 VBP denotes are
T20358 9542-9546 NNP denotes CYLD
T20357 9538-9541 CC denotes and
T20356 9534-9537 CD denotes A20
T20355 9532-9533 . denotes .
T20354 9527-9532 NNS denotes TRAFs
T20353 9521-9526 JJ denotes other
T20352 9516-9520 IN denotes with
T20351 9506-9515 VBG denotes competing
T20350 9503-9505 IN denotes by
T20349 9494-9502 RB denotes probably
T20348 9489-9493 JJS denotes most
T20347 9487-9488 , denotes ,
T20346 9477-9487 NN denotes activation
T20345 9471-9476 JJ denotes NF-κB
T20344 9462-9470 VB denotes regulate
T20343 9451-9461 RB denotes negatively
T20342 9447-9450 MD denotes can
T20341 9445-9446 , denotes ,
T20340 9437-9445 NN denotes activity
T20339 9430-9436 NN denotes ligase
T20338 9420-9429 NN denotes ubiquitin
T20337 9417-9419 DT denotes no
T20336 9413-9416 VBZ denotes has
T20335 9407-9412 WDT denotes which
T20334 9405-9406 , denotes ,
T20333 9400-9405 CD denotes TRAF1
T20332 9398-9399 . denotes .
T20331 9388-9398 NN denotes expression
T20330 9383-9387 NN denotes gene
T20329 9376-9382 NN denotes target
T20328 9368-9375 VB denotes promote
T20327 9364-9367 CC denotes and
T20326 9356-9363 NN denotes nucleus
T20325 9352-9355 DT denotes the
T20324 9349-9351 TO denotes to
T20323 9337-9348 VB denotes translocate
T20322 9334-9336 TO denotes to
T20321 9332-9333 -RRB- denotes )
T20320 9329-9332 CD denotes p50
T20319 9325-9328 CC denotes and
T20318 9321-9324 CD denotes p65
T20317 9318-9320 IN denotes of
T20316 9306-9317 NN denotes heterodimer
T20315 9304-9305 DT denotes a
T20314 9301-9303 IN denotes as
T20313 9295-9300 VBN denotes shown
T20312 9290-9294 RB denotes here
T20311 9289-9290 -LRB- denotes (
T20310 9283-9288 NNP denotes NF-κB
T20309 9276-9282 VBZ denotes allows
T20308 9271-9275 DT denotes This
T20307 9269-9270 . denotes .
T20306 9258-9269 NN denotes degradation
T20305 9246-9257 JJ denotes proteasomal
T20304 9242-9245 CC denotes and
T20303 9227-9241 NN denotes ubiquitination
T20302 9216-9226 JJ denotes K48-linked
T20301 9212-9215 PRP$ denotes its
T20300 9201-9211 VBG denotes triggering
T20299 9199-9200 , denotes ,
T20298 9195-9199 NNP denotes IκBα
T20297 9180-9194 NNS denotes phosphorylates
T20296 9175-9179 NN denotes turn
T20295 9172-9174 IN denotes in
T20294 9166-9171 WDT denotes which
T20293 9164-9165 , denotes ,
T20292 9160-9164 NNP denotes IKK2
T20291 9150-9159 VBZ denotes activates
T20290 9146-9149 CC denotes and
T20289 9131-9145 VBZ denotes phosphorylates
T20288 9126-9130 RB denotes then
T20287 9121-9125 CD denotes TAK1
T20286 9119-9120 . denotes .
T20285 9115-9119 CD denotes TAK1
T20284 9111-9114 CC denotes and
T20283 9106-9110 CD denotes IKK2
T20282 9093-9105 RB denotes respectively
T20281 9090-9092 IN denotes of
T20280 9079-9089 NN denotes activation
T20279 9075-9078 CC denotes and
T20278 9063-9074 NN denotes recruitment
T20277 9059-9062 DT denotes the
T20276 9056-9058 IN denotes in
T20275 9046-9055 VBG denotes resulting
T20274 9044-9045 , denotes ,
T20273 9036-9044 NNS denotes proteins
T20272 9032-9035 NNP denotes TAB
T20271 9028-9031 CC denotes and
T20270 9023-9027 NNP denotes NEMO
T20269 9020-9022 IN denotes by
T20268 9009-9019 VBN denotes recognised
T20267 9006-9008 VBZ denotes is
T20266 9004-9005 , denotes ,
T20265 8999-9004 NNP denotes IRAK1
T20264 8995-8998 CC denotes and
T20263 8990-8994 NNP denotes RIP1
T20262 8988-8989 , denotes ,
T20261 8983-8988 NNP denotes TRAFs
T20260 8980-8982 IN denotes of
T20259 8961-8979 NN denotes polyubiquitination
T20258 8950-8960 JJ denotes K63-linked
T20257 8948-8949 . denotes .
T20256 8940-8948 NN denotes receptor
T20255 8936-8939 DT denotes the
T20254 8933-8935 TO denotes to
T20253 8931-8932 -RRB- denotes )
T20252 8926-8931 NNP denotes cIAP2
T20251 8924-8925 , denotes ,
T20250 8919-8924 NNP denotes cIAP1
T20249 8917-8918 , denotes ,
T20248 8912-8917 CD denotes TRAF6
T20247 8910-8911 , denotes ,
T20246 8905-8910 CD denotes TRAF2
T20245 8904-8905 -LRB- denotes (
T20244 8896-8903 NNS denotes ligases
T20243 8886-8895 NN denotes ubiquitin
T20242 8882-8885 CC denotes and
T20241 8880-8881 , denotes ,
T20240 8879-8880 -RRB- denotes )
T20239 8874-8879 NNP denotes IRAK4
T20238 8872-8873 , denotes ,
T20237 8867-8872 NNP denotes IRAK1
T20236 8865-8866 , denotes ,
T20235 8861-8865 CD denotes RIP1
T20234 8860-8861 -LRB- denotes (
T20233 8852-8859 NNS denotes kinases
T20232 8850-8851 , denotes ,
T20231 8849-8850 -RRB- denotes )
T20230 8848-8849 -RRB- denotes )
T20229 8844-8848 NNP denotes TRIF
T20228 8843-8844 -LRB- denotes (
T20227 8838-8842 NNP denotes IFNβ
T20226 8821-8837 JJ denotes adaptor-inducing
T20225 8803-8820 JJ denotes domain-containing
T20224 8799-8802 NNP denotes TIR
T20223 8797-8798 , denotes ,
T20222 8794-8797 NNP denotes MAL
T20221 8792-8793 , denotes ,
T20220 8787-8792 NNP denotes MyD88
T20219 8785-8786 , denotes ,
T20218 8784-8785 -RRB- denotes )
T20217 8779-8784 NNP denotes TRADD
T20216 8778-8779 -LRB- denotes (
T20215 8770-8777 NN denotes protein
T20214 8763-8769 NN denotes domain
T20213 8757-8762 NN denotes death
T20212 8744-8756 JJ denotes 1-associated
T20211 8735-8743 NN denotes receptor
T20210 8731-8734 NN denotes TNF
T20209 8730-8731 -LRB- denotes (
T20208 8721-8729 NNS denotes proteins
T20207 8713-8720 NN denotes adaptor
T20206 8704-8712 JJ denotes specific
T20205 8701-8703 IN denotes of
T20204 8689-8700 NN denotes recruitment
T20203 8685-8688 DT denotes the
T20202 8677-8684 NN denotes trigger
T20201 8672-8676 CD denotes TLR4
T20200 8668-8671 CC denotes and
T20199 8666-8667 , denotes ,
T20198 8662-8666 NNP denotes RANK
T20197 8660-8661 , denotes ,
T20196 8656-8660 NNP denotes CD40
T20195 8654-8655 , denotes ,
T20194 8649-8654 CD denotes TNFR1
T20193 8646-8648 IN denotes as
T20192 8641-8645 JJ denotes such
T20191 8631-8640 NNS denotes receptors
T20190 8622-8630 NN denotes membrane
T20189 8613-8621 JJ denotes specific
T20458 10176-10181 JJ denotes NF-κB
T20457 10173-10175 IN denotes of
T20456 10162-10172 NN denotes regulation
T20455 10153-10161 NN denotes feedback
T20454 10144-10152 JJ denotes negative
T20453 10140-10143 DT denotes the
T20452 10137-10139 IN denotes in
T20451 10132-10136 PRP denotes them
T20450 10120-10131 VBG denotes implicating
T20449 10118-10119 , denotes ,
T20448 10109-10118 JJ denotes dependent
T20447 10103-10108 JJ denotes NF-κB
T20446 10100-10102 VBZ denotes is
T20445 10090-10099 NNS denotes molecules
T20444 10079-10089 JJ denotes regulatory
T20443 10070-10078 JJ denotes negative
T20442 10064-10069 DT denotes these
T20441 10061-10063 IN denotes of
T20440 10056-10060 JJ denotes many
T20439 10053-10055 IN denotes of
T20438 10042-10052 NN denotes expression
T20437 10038-10041 DT denotes The
T20436 10036-10037 . denotes .
T20435 10031-10036 NNP denotes TRAF6
T20434 10027-10030 CC denotes and
T20433 10021-10026 NNP denotes IRAK1
T20432 10018-10020 TO denotes to
T20431 10010-10017 JJ denotes binding
T20430 10006-10009 IN denotes for
T20429 10001-10005 CD denotes TLR4
T20428 9996-10000 IN denotes with
T20427 9988-9995 VB denotes compete
T20426 9985-9987 TO denotes to
T20425 9976-9984 VBN denotes proposed
T20424 9971-9975 VBN denotes been
T20423 9967-9970 VBZ denotes has
T20422 9961-9966 WDT denotes which
T20421 9959-9960 , denotes ,
T20420 9953-9959 NNP denotes SIGIRR
T20419 9945-9952 NN denotes protein
T20418 9931-9944 NN denotes transmembrane
T20417 9927-9930 DT denotes the
T20416 9924-9926 IN denotes by
T20415 9914-9923 VBN denotes inhibited
T20414 9911-9913 VB denotes be
T20413 9906-9910 RB denotes also
T20412 9902-9905 MD denotes can
T20411 9891-9901 NN denotes signalling
T20410 9887-9890 NNP denotes TLR
T20409 9885-9886 , denotes ,
T20408 9878-9885 RB denotes Finally
T20407 9876-9877 . denotes .
T20406 9871-9876 NNP denotes TRAF6
T20405 9867-9870 CC denotes and
T20188 8610-8612 IN denotes of
T20187 8599-8609 NN denotes engagement
T20186 8592-8598 NNP denotes Ligand
T20185 8590-8591 . denotes .
T20184 8580-8590 NNS denotes regulators
T20183 8571-8579 JJ denotes negative
T20182 8567-8570 CC denotes and
T20181 8556-8566 VBG denotes signalling
T20180 8550-8555 NNP denotes NF-κB
T20179 8540-8549 NNP denotes Canonical
T19188 33648-33650 NNP denotes RA
T19187 33645-33647 IN denotes as
T19186 33640-33644 JJ denotes such
T19185 33631-33639 NNS denotes diseases
T19184 33618-33630 JJ denotes inflammatory
T19183 33614-33617 IN denotes for
T19182 33603-33613 NNS denotes treatments
T19181 33599-33602 JJ denotes new
T19180 33596-33598 TO denotes to
T19179 33591-33595 VB denotes lead
T19178 33587-33590 MD denotes may
T19177 33577-33586 NN denotes knowledge
T19176 33572-33576 DT denotes this
T19175 33568-33571 WRB denotes how
T19174 33566-33567 , denotes ,
T19173 33555-33566 RB denotes importantly
T19172 33550-33554 RBR denotes more
T19171 33548-33549 , denotes ,
T19170 33545-33548 CC denotes and
T19169 33543-33544 , denotes ,
T19168 33534-33543 VBN denotes organised
T19167 33531-33533 VBZ denotes is
T19166 33520-33530 NN denotes signalling
T19165 33514-33519 JJ denotes NF-κB
T19164 33510-33513 WRB denotes how
T19163 33502-33509 VB denotes clarify
T19162 33499-33501 TO denotes to
T19161 33493-33498 NN denotes order
T19160 33490-33492 IN denotes in
T19159 33481-33489 NN denotes question
T19158 33471-33480 JJ denotes important
T19157 33468-33470 DT denotes an
T19156 33465-33467 VB denotes be
T19155 33460-33464 MD denotes will
T19154 33450-33459 VBN denotes regulated
T19153 33439-33449 PRP denotes themselves
T19152 33435-33438 VBP denotes are
T19151 33427-33434 NNS denotes signals
T19150 33416-33426 JJ denotes regulatory
T19149 33410-33415 DT denotes these
T19148 33406-33409 PDT denotes all
T19147 33402-33405 WRB denotes How
T19146 33400-33401 . denotes .
T19145 33392-33400 VBN denotes expected
T19144 33389-33391 VB denotes be
T19143 33385-33388 MD denotes can
T19142 33374-33384 NN denotes complexity
T19141 33366-33373 JJ denotes intense
T19140 33364-33365 , denotes ,
T19139 33358-33364 VBP denotes target
T19138 33353-33357 PRP denotes they
T19137 33347-33352 NNS denotes mRNAs
T19136 33338-33346 JJ denotes multiple
T19135 33334-33337 DT denotes the
T19134 33330-33333 CC denotes and
T19133 33323-33329 NNS denotes humans
T19132 33320-33322 IN denotes in
T19131 33313-33319 NNS denotes miRNAs
T19130 33310-33312 IN denotes of
T19129 33303-33309 NN denotes number
T19128 33299-33302 DT denotes the
T19127 33293-33298 VBN denotes given
T19126 33291-33292 , denotes ,
T19125 33283-33291 NN denotes addition
T19124 33280-33282 IN denotes In
T19123 33278-33279 . denotes .
T19122 33274-33278 PRP denotes them
T19121 33266-33273 IN denotes between
T19120 33253-33265 NN denotes relationship
T19119 33249-33252 DT denotes the
T19118 33245-33248 CC denotes and
T19117 33234-33244 NNS denotes regulators
T19116 33228-33233 DT denotes these
T19115 33225-33227 IN denotes of
T19114 33220-33224 DT denotes each
T19113 33217-33219 IN denotes of
T19112 33212-33216 NN denotes role
T19111 33203-33211 JJ denotes specific
T19110 33199-33202 DT denotes the
T19109 33196-33198 IN denotes of
T19108 33187-33195 NN denotes question
T19107 33183-33186 DT denotes the
T19106 33176-33182 VBZ denotes raises
T19105 33174-33175 , denotes ,
T19104 33167-33174 RB denotes however
T19103 33165-33166 , denotes ,
T19102 33158-33165 NN denotes pathway
T19101 33152-33157 NNP denotes NF-κB
T19100 33148-33151 DT denotes the
T19099 33145-33147 IN denotes of
T19098 33134-33144 NN denotes regulation
T19097 33128-33133 JJ denotes tight
T19096 33126-33127 DT denotes a
T19095 33117-33125 VBG denotes ensuring
T19094 33106-33116 NNS denotes regulators
T19093 33097-33105 JJ denotes negative
T19092 33088-33096 JJ denotes multiple
T19091 33085-33087 IN denotes of
T19090 33075-33084 NN denotes existence
T19089 33071-33074 DT denotes The
T19088 33069-33070 . denotes .
T19087 33057-33069 NNS denotes therapeutics
T19086 33048-33056 JJ denotes specific
T19085 33045-33047 IN denotes of
T19084 33038-33044 NN denotes design
T19083 33034-33037 DT denotes the
T19082 33030-33033 IN denotes for
T19081 33020-33029 JJ denotes important
T19080 33015-33019 RB denotes very
T19079 33012-33014 VB denotes be
T19078 33007-33011 RB denotes thus
T19077 33003-33006 MD denotes can
T19076 32995-33002 NN denotes control
T19075 32989-32994 IN denotes under
T19074 32978-32988 NN denotes activation
T19073 32972-32977 JJ denotes NF-κB
T19072 32964-32971 VBG denotes Keeping
T19071 32962-32963 . denotes .
T19070 32951-32962 NN denotes destruction
T19069 32946-32950 NN denotes bone
T19068 32942-32945 CC denotes and
T19067 32932-32941 NN denotes cartilage
T19066 32929-32931 TO denotes to
T19065 32921-32928 VBG denotes leading
T19064 32918-32920 NNP denotes RA
T19063 32915-32917 IN denotes in
T19062 32905-32914 NNS denotes processes
T19061 32892-32904 JJ denotes inflammatory
T19060 32888-32891 DT denotes the
T19059 32885-32887 IN denotes in
T19058 32879-32884 NNS denotes roles
T19057 32871-32878 JJ denotes crucial
T19056 32865-32870 VBZ denotes plays
T19055 32857-32864 NNS denotes factors
T19054 32843-32856 NN denotes transcription
T19053 32840-32842 IN denotes of
T19052 32833-32839 NN denotes family
T19051 32827-32832 NNP denotes NF-κB
T19050 32823-32826 DT denotes The
T19189 33650-33651 . denotes .
T18500 32808-32809 . denotes .
T18499 32807-32808 NNP denotes ]
T18498 32799-32807 CD denotes 83,88,91
T18497 32798-32799 NNP denotes [
T18496 32785-32797 NN denotes pathogenesis
T18495 32781-32784 IN denotes for
T18494 32770-32780 NNS denotes biomarkers
T18493 32759-32769 JJ denotes diagnostic
T18492 32756-32758 IN denotes as
T18491 32746-32755 JJ denotes potential
T18490 32740-32745 PRP$ denotes their
T18489 32729-32739 VBG denotes indicating
T18488 32727-32728 , denotes ,
T18487 32719-32727 NNS denotes patients
T18486 32716-32718 NNP denotes RA
T18485 32713-32715 IN denotes in
T18484 32702-32712 NN denotes expression
T18483 32694-32701 JJ denotes altered
T18482 32691-32693 DT denotes an
T18481 32686-32690 VB denotes have
T18480 32683-32685 TO denotes to
T18479 32677-32682 VBN denotes shown
T18478 32672-32676 RB denotes also
T18477 32667-32671 VBD denotes were
T18476 32659-32666 JJ denotes miR-223
T18475 32655-32658 CC denotes and
T18474 32653-32654 , denotes ,
T18473 32646-32653 NNP denotes miR-132
T18472 32644-32645 , denotes ,
T18471 32638-32644 NNP denotes miR-16
T18470 32636-32637 , denotes ,
T18469 32629-32636 RB denotes Finally
T18468 32627-32628 . denotes .
T18467 32626-32627 NNP denotes ]
T18466 32624-32626 CD denotes 90
T18465 32623-32624 NNP denotes [
T18464 32611-32622 NNS denotes fibroblasts
T18463 32602-32610 JJ denotes synovial
T18462 32599-32601 NNP denotes RA
T18461 32596-32598 IN denotes in
T18460 32587-32595 VBN denotes detected
T18459 32582-32586 VBD denotes were
T18458 32580-32581 : denotes -
T18457 32575-32579 NN denotes IL-6
T18456 32571-32574 CC denotes and
T18455 32551-32570 NN denotes metalloproteinase-1
T18454 32544-32550 NN denotes matrix
T18453 32541-32543 IN denotes of
T18452 32531-32540 NN denotes secretion
T18451 32521-32530 VBN denotes increased
T18450 32518-32520 TO denotes to
T18449 32510-32517 VBG denotes leading
T18448 32508-32509 : denotes -
T18447 32500-32507 NN denotes miR-203
T18446 32497-32499 IN denotes of
T18445 32490-32496 NNS denotes levels
T18444 32481-32489 JJ denotes elevated
T18443 32479-32480 , denotes ,
T18442 32470-32479 RB denotes Similarly
T18441 32468-32469 . denotes .
T18440 32467-32468 NNP denotes ]
T18439 32465-32467 CD denotes 89
T18438 32464-32465 NNP denotes [
T18437 32455-32463 NNS denotes patients
T18436 32452-32454 NNP denotes RA
T18435 32447-32451 IN denotes from
T18434 32434-32446 NNS denotes synoviocytes
T18433 32431-32433 IN denotes in
T18432 32421-32430 VBN denotes decreased
T18431 32418-32420 VB denotes be
T18430 32415-32417 TO denotes to
T18429 32409-32414 VBN denotes shown
T18428 32405-32408 VBD denotes was
T18427 32403-32404 : denotes -
T18426 32401-32402 LS denotes 1
T18425 32393-32400 NN denotes protein
T18386 32152-32159 NNP denotes miR-155
T18385 32148-32151 CC denotes and
T18384 32140-32147 NNP denotes miR-146
T18383 32132-32139 IN denotes Besides
T18382 32130-32131 . denotes .
T18381 32124-32130 NN denotes cohort
T18380 32111-32123 JJ denotes well-defined
T18379 32107-32110 CC denotes and
T18378 32101-32106 JJ denotes large
T18377 32099-32100 DT denotes a
T18376 32093-32098 VBG denotes using
T18375 32080-32092 NN denotes confirmation
T18374 32072-32079 VB denotes require
T18373 32067-32071 MD denotes will
T18372 32062-32066 DT denotes this
T18371 32058-32061 CC denotes but
T18370 32056-32057 , denotes ,
T18369 32055-32056 NNP denotes ]
T18368 32053-32055 CD denotes 88
T18367 32052-32053 NNP denotes [
T18366 32043-32051 NN denotes efficacy
T18365 32033-32042 NN denotes treatment
T18364 32030-32032 CC denotes or
T18363 32028-32029 , denotes ,
T18362 32017-32028 NN denotes progression
T18361 32015-32016 , denotes ,
T18360 32006-32015 NN denotes diagnosis
T18359 31998-32005 NN denotes disease
T18358 31994-31997 IN denotes for
T18357 31987-31993 NN denotes marker
T18356 31985-31986 DT denotes a
T18355 31982-31984 IN denotes as
T18354 31975-31981 JJ denotes useful
T18353 31963-31974 RB denotes potentially
T18352 31960-31962 VBZ denotes is
T18351 31951-31959 NNS denotes patients
T18350 31948-31950 NNP denotes RA
T18349 31945-31947 IN denotes in
T18348 31934-31944 NN denotes expression
T18347 31924-31933 VBN denotes increased
T18346 31918-31923 PRP$ denotes their
T18345 31916-31917 , denotes ,
T18344 31908-31916 NN denotes addition
T18343 31905-31907 IN denotes In
T18342 31903-31904 . denotes .
T18341 31892-31903 JJ denotes substantial
T18340 31889-31891 VBZ denotes is
T18339 31878-31888 NNS denotes treatments
T18338 31874-31877 JJ denotes new
T18337 31871-31873 IN denotes of
T18336 31859-31870 NN denotes development
T18335 31855-31858 DT denotes the
T18334 31851-31854 IN denotes for
T18333 31841-31850 NN denotes potential
T18332 31835-31840 PRP$ denotes their
T18331 31831-31834 CC denotes and
T18330 31828-31830 NNP denotes RA
T18329 31825-31827 IN denotes in
T18328 31812-31824 NN denotes inflammation
T18327 31809-31811 IN denotes of
T18326 31798-31808 NNS denotes regulators
T18325 31789-31797 JJ denotes negative
T18324 31779-31788 JJ denotes important
T18323 31776-31778 VB denotes be
T18322 31766-31775 RB denotes therefore
T18321 31762-31765 MD denotes may
T18320 31754-31761 NN denotes miR-155
T18319 31750-31753 CC denotes and
T18318 31742-31749 NN denotes miR-146
T18317 31740-31741 . denotes .
T18316 31739-31740 NNP denotes ]
T18315 31737-31739 CD denotes 87
T18314 31736-31737 NNP denotes [
T18313 31733-31735 NNP denotes RA
T18312 31730-31732 IN denotes of
T18311 31717-31729 NN denotes pathogenesis
T18310 31713-31716 DT denotes the
T18309 31710-31712 IN denotes in
T18308 31702-31709 NN denotes process
T18307 31698-31701 JJ denotes key
T18306 31696-31697 DT denotes a
T18305 31694-31695 , denotes ,
T18304 31684-31694 NN denotes production
T18303 31680-31683 NNP denotes TNF
T18302 31672-31679 VB denotes promote
T18301 31669-31671 TO denotes to
T18300 31663-31668 VBN denotes shown
T18299 31659-31662 VBD denotes was
T18298 31651-31658 NN denotes miR-155
T18297 31649-31650 , denotes ,
T18296 31641-31649 RB denotes Moreover
T18295 31639-31640 . denotes .
T18294 31638-31639 NNP denotes ]
T18293 31636-31638 CD denotes 81
T18292 31635-31636 NNP denotes [
T18278 31521-31524 NNP denotes TLR
T18277 31517-31520 DT denotes the
T18276 31509-31516 VB denotes prevent
T18275 31506-31508 TO denotes to
T18274 31501-31505 JJ denotes able
T18273 31497-31500 VBD denotes was
T18272 31485-31496 NNS denotes fibroblasts
T18271 31476-31484 JJ denotes synovial
T18270 31473-31475 IN denotes in
T18269 31458-31472 NN denotes overexpression
T18268 31450-31457 NN denotes miR-155
T18267 31448-31449 . denotes .
T18266 31447-31448 NNP denotes ]
T18265 31445-31447 CD denotes 86
T18264 31444-31445 NNP denotes [
T18263 31429-31443 NN denotes susceptibility
T18262 31426-31428 NNP denotes RA
T18261 31421-31425 IN denotes with
T18260 31410-31420 VBN denotes associated
T18259 31407-31409 VB denotes be
T18258 31404-31406 TO denotes to
T18257 31398-31403 VBN denotes shown
T18256 31389-31397 RB denotes recently
T18255 31385-31388 VBD denotes was
T18254 31380-31384 NN denotes gene
T18253 31373-31379 NN denotes target
T18252 31364-31372 NN denotes miR-146a
T18251 31360-31363 DT denotes the
T18250 31357-31359 IN denotes of
T18249 31353-31356 NNP denotes UTR
T18248 31352-31353 : denotes -
T18247 31351-31352 '' denotes '
T18246 31350-31351 CD denotes 3
T18245 31346-31349 DT denotes the
T18244 31343-31345 IN denotes in
T18243 31330-31342 NN denotes polymorphism
T18242 31328-31329 DT denotes a
T18241 31326-31327 , denotes ,
T18240 31313-31326 RB denotes Interestingly
T18239 31311-31312 . denotes .
T18238 31310-31311 NNP denotes ]
T18237 31305-31310 CD denotes 84,85
T18236 31304-31305 NNP denotes [
T18235 31295-31303 NNS denotes patients
T18234 31292-31294 NNP denotes RA
T18206 31148-31149 , denotes ,
T18205 31147-31148 NNP denotes ]
T18204 31142-31147 CD denotes 81,82
T18203 31141-31142 NNP denotes [
T18202 31134-31140 NN denotes tissue
T18201 31125-31133 JJ denotes synovial
T18200 31121-31124 CC denotes and
T18199 31109-31120 NNS denotes fibroblasts
T18198 31100-31108 JJ denotes synovial
T18197 31097-31099 NNP denotes RA
T18196 31094-31096 IN denotes in
T18195 31087-31093 NNS denotes levels
T18194 31080-31086 JJR denotes higher
T18193 31077-31079 IN denotes at
T18192 31067-31076 VBN denotes expressed
T18191 31063-31066 VBP denotes are
T18190 31055-31062 NNP denotes miR-155
T18189 31051-31054 CC denotes and
T18188 31043-31050 NNP denotes miR-146
T18187 31038-31042 DT denotes both
T18186 31036-31037 , denotes ,
T18185 31029-31036 RB denotes Notably
T18184 31027-31028 . denotes .
T18183 31026-31027 NNP denotes ]
T18182 31021-31026 CD denotes 79,80
T18181 31020-31021 NNP denotes [
T18180 31015-31019 NNP denotes RIP1
T18179 31011-31014 CC denotes and
T18178 31006-31010 NNP denotes IKKε
T18177 30996-31005 NNS denotes molecules
T18176 30985-30995 VBG denotes signalling
T18175 30979-30984 NN denotes NF-κB
T18174 30975-30978 DT denotes the
T18173 30971-30974 IN denotes for
T18172 30959-30970 NNS denotes transcripts
T18171 30952-30958 VB denotes target
T18424 32377-32392 JJ denotes chemoattractant
T18423 32368-32376 NN denotes monocyte
T18422 32358-32367 NN denotes chemokine
T18421 32354-32357 DT denotes the
T18420 32351-32353 IN denotes of
T18419 32341-32350 NN denotes regulator
T18418 32337-32340 JJ denotes key
T18417 32335-32336 DT denotes a
T18416 32333-32334 : denotes -
T18415 32324-32332 NN denotes miR-124a
T18414 32322-32323 , denotes ,
T18413 32315-32322 NN denotes context
T18412 32310-32314 DT denotes this
T18411 32307-32309 IN denotes In
T18410 32305-32306 . denotes .
T18409 32295-32305 VBN denotes identified
T18408 32286-32294 RB denotes recently
T18407 32281-32285 VBD denotes were
T18406 32271-32280 NN denotes pathology
T18405 32268-32270 NNP denotes RA
T18404 32265-32267 IN denotes in
T18403 32255-32264 NNS denotes responses
T18402 32242-32254 JJ denotes inflammatory
T18401 32226-32241 JJ denotes NF-κB-dependent
T18400 32223-32225 IN denotes of
T18399 32215-32222 NN denotes control
T18398 32211-32214 DT denotes the
T18397 32208-32210 IN denotes in
T18396 32203-32207 NN denotes role
T18395 32193-32202 JJ denotes potential
T18394 32191-32192 DT denotes a
T18393 32186-32190 IN denotes with
T18392 32179-32185 NNS denotes miRNAs
T18391 32173-32178 JJ denotes other
T18390 32170-32172 IN denotes of
T18389 32163-32169 NN denotes number
T18388 32161-32162 DT denotes a
T18387 32159-32160 , denotes ,
T18170 30949-30951 TO denotes to
T18169 30943-30948 VBN denotes shown
T18168 30939-30942 VBD denotes was
T18167 30931-30938 NN denotes miR-155
T18166 30929-30930 , denotes ,
T18165 30920-30929 RB denotes Similarly
T18164 30918-30919 . denotes .
T18163 30917-30918 -RRB- denotes )
T18162 30916-30917 CD denotes 1
T18161 30909-30915 NNP denotes Figure
T18160 30908-30909 -LRB- denotes (
T18159 30906-30907 NNP denotes ]
T18158 30904-30906 CD denotes 78
T18157 30903-30904 NNP denotes [
T18156 30894-30902 JJ denotes miR-146a
T18155 30891-30893 IN denotes of
T18154 30885-30890 NNS denotes genes
T18153 30878-30884 NN denotes target
T18152 30875-30877 IN denotes as
T18151 30864-30874 VBN denotes identified
T18150 30859-30863 VBD denotes were
T18149 30853-30858 NNP denotes TRAF6
T18148 30849-30852 CC denotes and
T18147 30843-30848 NNP denotes IRAK1
T18146 30833-30842 NNS denotes molecules
T18145 30822-30832 VBG denotes signalling
T18144 30816-30821 NN denotes NF-κB
T18143 30812-30815 DT denotes the
T18142 30808-30811 CC denotes and
T18141 30806-30807 , denotes ,
T18140 30802-30806 NN denotes gene
T18139 30786-30801 JJ denotes NF-κB-dependent
T18138 30783-30785 DT denotes an
T18137 30780-30782 VBZ denotes is
T18136 30771-30779 NN denotes miR-146a
T18135 30769-30770 , denotes ,
T18134 30761-30769 NN denotes addition
T18133 30758-30760 IN denotes In
T18132 30756-30757 . denotes .
T18131 30755-30756 NNP denotes ]
T18130 30750-30755 CD denotes 78,79
T18129 30749-30750 NNP denotes [
T18128 30744-30748 NNP denotes TLRs
T18127 30740-30743 CC denotes and
T18126 30736-30739 NNP denotes TNF
T18125 30734-30735 , denotes ,
T18124 30729-30734 NN denotes IL-1β
T18123 30726-30728 IN denotes as
T18122 30721-30725 JJ denotes such
T18121 30713-30720 NNS denotes stimuli
T18120 30700-30712 JJ denotes inflammatory
T18119 30697-30699 IN denotes by
T18118 30689-30696 VBN denotes induced
T18117 30686-30688 VB denotes be
T18116 30682-30685 MD denotes can
T18115 30675-30681 NNS denotes miRNAs
T18114 30669-30674 DT denotes these
T18113 30663-30668 IN denotes since
T18112 30661-30662 , denotes ,
T18111 30656-30661 NNP denotes NF-κB
T18110 30653-30655 TO denotes to
T18109 30642-30652 NN denotes signalling
T18108 30629-30641 JJ denotes inflammatory
T18107 30625-30628 IN denotes for
T18106 30616-30624 NN denotes interest
T18105 30605-30615 JJ denotes particular
T18104 30602-30604 IN denotes of
T18103 30598-30601 VBP denotes are
T18102 30590-30597 NN denotes miR-155
T18101 30586-30589 CC denotes and
T18100 30584-30585 NN denotes b
T18099 30583-30584 NN denotes /
T18098 30575-30583 JJ denotes miR-146a
T18097 30573-30574 . denotes .
T18096 30572-30573 NNP denotes ]
T18095 30570-30572 CD denotes 77
T16858 29363-29370 RB denotes however
T16857 29361-29362 , denotes ,
T16856 29356-29361 NNS denotes cells
T16855 29346-29355 JJ denotes dendritic
T16854 29330-29345 JJ denotes TRAF1-deficient
T16853 29328-29329 . denotes .
T16852 29318-29328 NN denotes activation
T16851 29312-29317 NN denotes NF-κB
T16850 29299-29311 JJ denotes CD40-induced
T16849 29296-29298 IN denotes of
T16848 29286-29295 NN denotes regulator
T16847 29277-29285 JJ denotes negative
T16846 29275-29276 DT denotes a
T16845 29272-29274 IN denotes as
T16844 29262-29271 NNS denotes functions
T16843 29257-29261 RB denotes also
T16842 29251-29256 CD denotes TRAF1
T16841 29249-29250 . denotes .
T16840 29242-29249 NN denotes pathway
T16839 29231-29241 VBG denotes signalling
T16838 29225-29230 NN denotes NF-κB
T16837 29221-29224 DT denotes the
T16836 29218-29220 IN denotes of
T16835 29207-29217 NN denotes activation
T16834 29203-29206 CC denotes and
T16833 29189-29202 NN denotes proliferation
T16832 29180-29188 JJ denotes enhanced
T16831 29175-29179 IN denotes with
T16830 29173-29174 , denotes ,
T16829 29170-29173 NNP denotes TNF
T16828 29167-29169 TO denotes to
T16827 29150-29166 JJ denotes hyper-responsive
T16826 29146-29149 VBP denotes are
T16825 29140-29145 NNS denotes cells
T16824 29138-29139 NNP denotes T
T16823 29122-29137 JJ denotes TRAF1-deficient
T16822 29120-29121 . denotes .
T16821 29110-29120 NN denotes activation
T16820 29104-29109 NN denotes NF-κB
T16819 29092-29103 JJ denotes TNF-induced
T16818 29083-29091 NNS denotes inhibits
T16817 29077-29082 CD denotes TRAF1
T16816 29074-29076 IN denotes of
T16815 29059-29073 NN denotes overexpression
T16814 29055-29058 CC denotes and
T16813 29051-29054 NNP denotes TNF
T16812 29048-29050 IN denotes by
T16811 29038-29047 JJ denotes inducible
T16810 29035-29037 VBZ denotes is
T16809 29029-29034 CD denotes TRAF1
T16808 29026-29028 IN denotes of
T16807 29015-29025 NN denotes Expression
T16806 29013-29014 . denotes .
T16805 29012-29013 NNP denotes ]
T16804 29007-29012 CD denotes 71,72
T16803 29006-29007 NNP denotes [
T16802 28999-29005 NN denotes manner
T16801 28979-28998 JJ denotes cell-type-dependent
T16800 28977-28978 DT denotes a
T16799 28974-28976 IN denotes in
T16798 28965-28973 RB denotes possibly
T16797 28963-28964 , denotes ,
T16796 28954-28963 NNS denotes receptors
T16795 28947-28953 NN denotes family
T16794 28943-28946 NNP denotes TNF
T16793 28935-28942 JJ denotes certain
T16792 28932-28934 IN denotes by
T16791 28921-28931 NN denotes signalling
T16790 28915-28920 JJ denotes NF-κB
T16789 28912-28914 IN denotes of
T16788 28902-28911 NN denotes modulator
T16787 28893-28901 JJ denotes positive
T16786 28891-28892 DT denotes a
T16785 28887-28890 CC denotes and
T16784 28878-28886 JJ denotes negative
T16783 28876-28877 DT denotes a
T16782 28871-28875 DT denotes both
T16781 28868-28870 IN denotes as
T16780 28862-28867 CD denotes TRAF1
T16779 28858-28861 IN denotes for
T16778 28853-28857 NN denotes role
T16777 28851-28852 DT denotes a
T16776 28843-28850 VBP denotes support
T16775 28838-28842 NNS denotes data
T16774 28825-28837 VBG denotes Accumulating
T16773 28823-28824 . denotes .
T16772 28815-28823 NN denotes activity
T16771 28808-28814 NN denotes ligase
T16770 28798-28807 NN denotes ubiquitin
T16769 28792-28797 VBZ denotes lacks
T16768 28782-28791 RB denotes therefore
T16767 28778-28781 CC denotes and
T16766 28771-28777 NN denotes domain
T16765 28764-28770 NN denotes finger
T16764 28759-28763 NN denotes RING
T16763 28757-28758 DT denotes a
T16762 28751-28756 VBZ denotes lacks
T16761 28748-28750 PRP denotes it
T16760 28740-28747 IN denotes because
T16759 28733-28739 NN denotes family
T16758 28725-28732 NN denotes protein
T16757 28720-28724 NNP denotes TRAF
T16756 28716-28719 DT denotes the
T16755 28713-28715 IN denotes of
T16754 28706-28712 NN denotes member
T16753 28699-28705 JJ denotes unique
T16752 28697-28698 DT denotes a
T16751 28694-28696 VBZ denotes is
T16750 28688-28693 CD denotes TRAF1
T16749 28686-28687 CD denotes 1
T16748 28679-28685 NN denotes factor
T16747 28659-28678 JJ denotes receptor-associated
T16746 28655-28658 NNP denotes TNF
T16975 30081-30083 VB denotes be
T16974 30078-30080 TO denotes to
T16973 30071-30077 JJ denotes likely
T16972 30066-30070 RBR denotes more
T16971 30063-30065 VBZ denotes is
T16970 30057-30062 CD denotes TRAF1
T16969 30052-30056 IN denotes that
T16968 30042-30051 VBZ denotes indicates
T16967 30037-30041 NN denotes work
T16966 30026-30036 JJ denotes Subsequent
T16965 30024-30025 . denotes .
T16964 30023-30024 NNP denotes ]
T16963 30021-30023 CD denotes 74
T16962 30020-30021 NNP denotes [
T16961 30014-30019 VBZ denotes locus
T16960 30009-30013 NN denotes risk
T16959 30006-30008 NNP denotes RA
T16958 29996-30005 JJ denotes important
T16957 29993-29995 DT denotes an
T16956 29990-29992 IN denotes as
T16955 29984-29989 NN denotes locus
T16954 29982-29983 CD denotes 5
T16953 29972-29981 NN denotes component
T16952 29955-29971 NN denotes TRAF1-complement
T16951 29951-29954 DT denotes the
T16950 29948-29950 IN denotes at
T16949 29938-29947 NN denotes variation
T16948 29930-29937 JJ denotes genetic
T16947 29928-29929 DT denotes a
T16946 29917-29927 VBD denotes identified
T16945 29908-29916 NNS denotes controls
T16944 29902-29907 CD denotes 1,800
T16943 29898-29901 CC denotes and
T16942 29892-29897 NNS denotes cases
T16941 29889-29891 NNP denotes RA
T16940 29867-29888 JJ denotes autoantibody-positive
T16939 29861-29866 CD denotes 1,500
T16938 29847-29860 RB denotes approximately
T16937 29841-29846 IN denotes among
T16936 29836-29840 NNS denotes SNPs
T16935 29828-29835 CD denotes 300,000
T16934 29823-29827 IN denotes than
T16933 29818-29822 JJR denotes more
T16932 29808-29817 VBG denotes examining
T16931 29802-29807 NN denotes study
T16930 29790-29801 NN denotes association
T16929 29778-29789 JJ denotes genome-wide
T16928 29776-29777 DT denotes A
T16927 29774-29775 . denotes .
T16926 29773-29774 NNP denotes ]
T16925 29771-29773 CD denotes 73
T16924 29770-29771 NNP denotes [
T16923 29761-29769 VB denotes interact
T16922 29750-29760 RB denotes physically
T16921 29746-29749 MD denotes can
T16920 29743-29745 PRP denotes it
T16919 29737-29742 WDT denotes which
T16918 29732-29736 IN denotes with
T16917 29728-29731 NNP denotes A20
T16916 29720-29727 VB denotes recruit
T16915 29714-29719 MD denotes might
T16914 29708-29713 NNP denotes TRAF1
T16913 29706-29707 , denotes ,
T16912 29693-29706 RB denotes Alternatively
T16911 29691-29692 . denotes .
T16910 29683-29691 NNS denotes proteins
T16909 29672-29682 JJ denotes signalling
T16908 29666-29671 JJ denotes other
T16907 29663-29665 CC denotes or
T16906 29654-29662 NN denotes receptor
T16905 29650-29653 DT denotes the
T16904 29647-29649 TO denotes to
T16903 29639-29646 JJ denotes binding
T16902 29635-29638 IN denotes for
T16901 29627-29634 NNS denotes members
T16900 29620-29626 NN denotes family
T16899 29615-29619 NNP denotes TRAF
T16898 29610-29614 IN denotes with
T16897 29601-29609 VBZ denotes competes
T16896 29595-29600 CD denotes TRAF1
T16895 29593-29594 , denotes ,
T16894 29585-29593 RB denotes probably
T16893 29580-29584 JJS denotes Most
T16892 29578-29579 . denotes .
T16891 29571-29578 JJ denotes unclear
T16890 29565-29570 RB denotes still
T16889 29562-29564 VBZ denotes is
T16888 29551-29561 NN denotes activation
T16887 29548-29550 NN denotes κB
T16886 29546-29547 : denotes -
T16885 29544-29546 SYM denotes NF
T16884 29534-29543 VBZ denotes modulates
T16883 29528-29533 NNP denotes TRAF1
T16882 29522-29527 WDT denotes which
T16881 29519-29521 IN denotes by
T16880 29509-29518 NN denotes mechanism
T16879 29505-29508 DT denotes The
T16878 29503-29504 . denotes .
T16877 29498-29503 NNS denotes cells
T16876 29492-29497 DT denotes these
T16875 29489-29491 IN denotes in
T16874 29484-29488 NN denotes role
T16873 29473-29483 JJ denotes regulatory
T16872 29464-29472 JJ denotes positive
T16871 29462-29463 DT denotes a
T16870 29451-29461 VBG denotes suggesting
T16869 29449-29450 , denotes ,
T16868 29442-29449 NNS denotes factors
T16867 29426-29441 JJ denotes TRAF2-dependent
T16866 29423-29425 IN denotes by
T16865 29411-29422 NN denotes stimulation
T16864 29401-29410 JJ denotes secondary
T16863 29398-29400 TO denotes to
T16862 29388-29397 NNS denotes responses
T16861 29377-29387 JJ denotes attenuated
T16860 29372-29376 VBP denotes show
T16859 29370-29371 , denotes ,
T16027 28474-28485 VB denotes investigate
T16026 28471-28473 TO denotes to
T16025 28468-28470 CC denotes or
T16024 28466-28467 , denotes ,
T16023 28458-28466 NNS denotes patients
T16022 28450-28457 NN denotes control
T16021 28447-28449 IN denotes in
T16020 28436-28446 NN denotes expression
T16019 28432-28435 PRP$ denotes its
T16018 28427-28431 IN denotes with
T16017 28418-28426 NNS denotes patients
T16016 28415-28417 NNP denotes RA
T16015 28412-28414 IN denotes in
T16014 28405-28411 NNP denotes SIGIRR
T16013 28402-28404 IN denotes of
T16012 28391-28401 NN denotes expression
T16011 28387-28390 DT denotes the
T16010 28379-28386 VB denotes compare
T16009 28376-28378 TO denotes to
T16008 28364-28375 JJ denotes interesting
T16007 28361-28363 VB denotes be
T16006 28356-28360 MD denotes will
T16005 28353-28355 PRP denotes It
T16004 28351-28352 . denotes .
T16003 28350-28351 NNP denotes ]
T16002 28348-28350 CD denotes 70
T16001 28347-28348 NNP denotes [
T16000 28340-28346 NNS denotes models
T15999 28334-28339 NN denotes mouse
T15998 28324-28333 NNS denotes arthritis
T15997 28307-28323 JJ denotes collagen-induced
T15996 28304-28306 IN denotes as
T15995 28299-28303 RB denotes well
T15994 28296-28298 RB denotes as
T15993 28294-28295 , denotes ,
T15992 28285-28294 NNS denotes arthritis
T15991 28269-28284 JJ denotes zymosan-induced
T15990 28266-28268 IN denotes in
T15989 28258-28265 NN denotes disease
T15988 28251-28257 JJ denotes severe
T15987 28246-28250 RBR denotes more
T15986 28244-28245 DT denotes a
T15985 28234-28243 VBD denotes developed
T15984 28229-28233 NNS denotes mice
T15983 28212-28228 JJ denotes SIGIRR-deficient
T15982 28206-28211 IN denotes since
T15981 28204-28205 , denotes ,
T15980 28200-28204 NN denotes vivo
T15979 28197-28199 IN denotes in
T15978 28187-28196 VBN denotes confirmed
T15977 28179-28186 JJ denotes further
T15976 28175-28178 VBD denotes was
T15975 28168-28174 NNP denotes SIGIRR
T15974 28165-28167 IN denotes of
T15973 28156-28164 NN denotes function
T15972 28145-28155 JJ denotes inhibitory
T15971 28140-28144 DT denotes This
T15970 28138-28139 . denotes .
T15969 28133-28138 NNS denotes cells
T15968 28124-28132 JJ denotes synovial
T15967 28121-28123 NNP denotes RA
T15966 28115-28120 JJ denotes human
T15965 28112-28114 IN denotes by
T15964 28102-28111 NNS denotes cytokines
T15963 28089-28101 JJ denotes inflammatory
T15962 28086-28088 IN denotes of
T15961 28078-28085 NN denotes release
T15960 28066-28077 JJ denotes spontaneous
T15959 28062-28065 DT denotes the
T15958 28054-28061 VB denotes inhibit
T15957 28051-28053 TO denotes to
T15956 28045-28050 VBN denotes shown
T15955 28041-28044 VBD denotes was
T15954 28026-28040 NN denotes overexpression
T15953 28019-28025 NNP denotes SIGIRR
T15952 28017-28018 , denotes ,
T15951 28009-28017 RB denotes Recently
T15950 28007-28008 . denotes .
T15949 28006-28007 NNP denotes ]
T15948 28001-28006 CD denotes 69,70
T15947 28000-28001 NNP denotes [
T15946 27987-27999 NNS denotes macro-phages
T15945 27980-27986 JJ denotes mature
T15944 27977-27979 IN denotes in
T15943 27973-27976 RB denotes not
T15942 27969-27972 CC denotes but
T15941 27967-27968 , denotes ,
T15940 27962-27967 NNS denotes cells
T15939 27952-27961 JJ denotes dendritic
T15938 27943-27951 NN denotes immature
T15937 27939-27942 CC denotes and
T15936 27929-27938 NNS denotes monocytes
T15935 27927-27928 , denotes ,
T15934 27922-27927 NNS denotes cells
T15933 27911-27921 JJ denotes epithelial
T15932 27908-27910 IN denotes in
T15931 27898-27907 VBN denotes expressed
T15930 27892-27897 VBG denotes being
T15929 27890-27891 , denotes ,
T15928 27883-27890 NN denotes pattern
T15927 27872-27882 NN denotes expression
T15926 27861-27871 VBN denotes restricted
T15925 27856-27860 RB denotes very
T15924 27854-27855 DT denotes a
T15923 27850-27853 VBZ denotes has
T15922 27843-27849 NNP denotes SIGIRR
T15921 27841-27842 . denotes .
T15920 27833-27841 JJ denotes unlikely
T15919 27829-27832 RB denotes not
T15918 27826-27828 VBZ denotes is
T15917 27823-27825 NNP denotes RA
T15916 27820-27822 IN denotes in
T15915 27813-27819 NNP denotes SIGIRR
T15914 27809-27812 IN denotes for
T15913 27804-27808 NN denotes role
T15912 27793-27803 JJ denotes regulatory
T15911 27791-27792 DT denotes a
T15910 27789-27790 , denotes ,
T15909 27788-27789 NNP denotes ]
T15908 27786-27788 CD denotes 68
T15907 27785-27786 NNP denotes [
T15906 27782-27784 NNP denotes RA
T15905 27779-27781 IN denotes in
T15904 27770-27778 VBD denotes observed
T15903 27757-27769 NN denotes inflammation
T15902 27749-27756 JJ denotes chronic
T15901 27745-27748 DT denotes the
T15900 27742-27744 IN denotes in
T15899 27731-27741 VBG denotes signalling
T15898 27727-27730 NNP denotes TLR
T15897 27723-27726 CC denotes and
T15896 27717-27722 NN denotes IL-1R
T15895 27714-27716 IN denotes of
T15894 27709-27713 NN denotes role
T15893 27699-27708 JJ denotes important
T15892 27695-27698 DT denotes the
T15891 27689-27694 VBN denotes Given
T15890 27687-27688 . denotes .
T15889 27686-27687 -RRB- denotes )
T15888 27685-27686 CD denotes 1
T15887 27678-27684 NNP denotes Figure
T15886 27677-27678 -LRB- denotes (
T15885 27675-27676 NNP denotes ]
T15884 27673-27675 CD denotes 67
T15883 27672-27673 NNP denotes [
T15882 27666-27671 NNP denotes TRAF6
T15881 27663-27665 CC denotes or
T15880 27657-27662 NNP denotes IRAK1
T15879 27655-27656 , denotes ,
T15878 27650-27655 NNP denotes MyD88
T15877 27648-27649 , denotes ,
T15876 27639-27648 NNS denotes receptors
T15875 27633-27638 DT denotes these
T15874 27628-27632 IN denotes with
T15873 27616-27627 NN denotes interaction
T15872 27609-27615 JJ denotes direct
T15871 27601-27608 IN denotes through
T15870 27592-27600 RB denotes probably
T15869 27590-27591 , denotes ,
T15868 27580-27590 NN denotes signalling
T15867 27576-27579 NNP denotes TLR
T15866 27572-27575 CC denotes and
T15865 27566-27571 NN denotes IL-1R
T15864 27563-27565 IN denotes of
T15863 27553-27562 NN denotes inhibitor
T15862 27550-27552 DT denotes an
T15861 27547-27549 IN denotes as
T15860 27533-27546 VBN denotes characterised
T15859 27521-27532 RB denotes extensively
T15858 27516-27520 VBN denotes been
T15857 27512-27515 VBZ denotes has
T15856 27507-27511 WDT denotes that
T15855 27500-27506 NN denotes family
T15854 27498-27499 NNP denotes R
T15853 27496-27498 CD denotes -1
T15852 27490-27496 NNP denotes TLR/IL
T15851 27486-27489 DT denotes the
T15850 27483-27485 IN denotes of
T15849 27476-27482 NN denotes member
T15848 27474-27475 DT denotes a
T15847 27471-27473 VBZ denotes is
T15846 27469-27470 , denotes ,
T15845 27464-27469 CD denotes TIR-8
T15844 27461-27463 IN denotes as
T15843 27455-27460 VBN denotes known
T15842 27450-27454 RB denotes also
T15841 27448-27449 , denotes ,
T15840 27441-27448 NN denotes protein
T15839 27439-27440 -RRB- denotes )
T15838 27433-27439 NNP denotes SIGIRR
T15837 27432-27433 -LRB- denotes (
T15836 27415-27431 JJ denotes receptor-related
T15835 27410-27414 NNP denotes IL-1
T15834 27388-27409 NN denotes Single-immunoglobulin
T15833 27380-27387 NN denotes protein
T15832 27363-27379 JJ denotes receptor-related
T15831 27358-27362 NNP denotes IL-1
T15830 27336-27357 NN denotes Single-immunoglobulin
T16056 28652-28653 . denotes .
T16055 28650-28652 NNP denotes RA
T16054 28647-28649 IN denotes in
T16053 28640-28646 NN denotes target
T16052 28628-28639 JJ denotes therapeutic
T16051 28616-28627 JJ denotes interesting
T16050 28613-28615 DT denotes an
T16049 28610-28612 VB denotes be
T16048 28605-28609 RB denotes also
T16047 28601-28604 MD denotes may
T16046 28594-28600 NNP denotes SIGIRR
T16045 28592-28593 , denotes ,
T16044 28585-28592 NN denotes pattern
T16043 28574-28584 NN denotes expression
T16042 28563-28573 VBN denotes restricted
T16041 28559-28562 PRP$ denotes its
T16040 28556-28558 IN denotes of
T16039 28548-28555 IN denotes Because
T16038 28546-28547 . denotes .
T16037 28538-28546 NNS denotes patients
T16036 28535-28537 NNP denotes RA
T16035 28532-28534 IN denotes in
T16034 28520-28531 VBN denotes compromised
T16033 28517-28519 VBZ denotes is
T16032 28510-28516 NNP denotes SIGIRR
T16031 28507-28509 IN denotes of
T16030 28498-28506 NN denotes function
T16029 28494-28497 DT denotes the
T16028 28486-28493 IN denotes whether
T13554 24915-24919 VBP denotes show
T15018 27333-27334 . denotes .
T15017 27331-27333 NNP denotes RA
T15016 27328-27330 IN denotes as
T15015 27323-27327 JJ denotes such
T15014 27313-27322 NNS denotes disorders
T15013 27308-27312 NN denotes bone
T15012 27305-27307 IN denotes of
T15011 27295-27304 NN denotes pathology
T15010 27291-27294 DT denotes the
T15009 27288-27290 IN denotes in
T15008 27279-27287 VBN denotes involved
T15007 27272-27278 NN denotes factor
T15006 27264-27271 JJ denotes genetic
T15005 27254-27263 JJ denotes potential
T15004 27252-27253 DT denotes a
T15003 27249-27251 IN denotes as
T15002 27244-27248 NNP denotes CYLD
T15001 27235-27243 VBP denotes indicate
T15000 27231-27234 CC denotes and
T14999 27212-27230 NN denotes osteoclastogenesis
T14998 27209-27211 IN denotes of
T14997 27198-27208 NN denotes regulation
T14996 27189-27197 JJ denotes negative
T14995 27185-27188 DT denotes the
T14994 27182-27184 IN denotes in
T14993 27177-27181 NN denotes role
T14992 27173-27176 JJ denotes key
T14991 27171-27172 DT denotes a
T14990 27165-27170 NNS denotes plays
T14989 27154-27164 VBG denotes signalling
T14988 27148-27153 NN denotes NF-κB
T14987 27135-27147 JJ denotes RANK-induced
T14986 27132-27134 IN denotes of
T14985 27120-27131 NN denotes inhibi-tion
T14984 27106-27119 JJ denotes CYLD-mediated
T14983 27101-27105 IN denotes that
T14982 27093-27100 VBP denotes suggest
T14981 27084-27092 NNS denotes findings
T14980 27078-27083 DT denotes These
T14979 27076-27077 . denotes .
T14978 27075-27076 NNP denotes ]
T14977 27073-27075 CD denotes 66
T14976 27072-27073 NNP denotes [
T14975 27067-27071 NN denotes loss
T14974 27062-27066 NN denotes bone
T14973 27050-27061 JJ denotes progressive
T14972 27042-27049 VB denotes develop
T14971 27038-27041 CC denotes and
T14970 27019-27037 NN denotes osteoclastogenesis
T14969 27010-27018 JJ denotes abnormal
T14968 27002-27009 NN denotes display
T14967 26997-27001 RB denotes also
T14966 26993-26996 CD denotes p62
T14965 26990-26992 IN denotes of
T14964 26985-26989 NN denotes form
T14963 26977-26984 VBN denotes mutated
T14962 26975-26976 DT denotes a
T14961 26964-26974 VBG denotes expressing
T14960 26959-26963 NNS denotes mice
T14959 26948-26958 JJ denotes transgenic
T14958 26943-26947 IN denotes that
T14957 26932-26942 VBG denotes mentioning
T14956 26926-26931 JJ denotes worth
T14955 26923-26925 VBZ denotes is
T14954 26920-26922 PRP denotes it
T14953 26918-26919 , denotes ,
T14952 26911-26918 NN denotes context
T14951 26906-26910 DT denotes this
T14950 26903-26905 IN denotes In
T14949 26901-26902 . denotes .
T14948 26896-26901 CD denotes TRAF6
T14947 26893-26895 IN denotes of
T14946 26876-26892 NN denotes deubiquitination
T14945 26862-26875 JJ denotes CYLD-mediated
T14944 26858-26861 DT denotes the
T14943 26855-26857 IN denotes by
T14942 26846-26854 VBN denotes followed
T14941 26844-26845 , denotes ,
T14940 26843-26844 NNP denotes ]
T14939 26841-26843 CD denotes 65
T14938 26840-26841 NNP denotes [
T14937 26838-26839 -RRB- denotes )
T14936 26837-26838 CD denotes 1
T14935 26824-26836 JJ denotes sequestosome
T14934 26821-26823 IN denotes as
T14933 26815-26820 VBN denotes known
T14932 26810-26814 RB denotes also
T14931 26809-26810 -LRB- denotes (
T14930 26805-26808 NN denotes p62
T14929 26797-26804 NN denotes protein
T14928 26789-26796 NN denotes adaptor
T14927 26771-26788 JJ denotes ubiquitin-binding
T14926 26767-26770 DT denotes the
T14925 26763-26766 IN denotes via
T14924 26757-26762 CD denotes TRAF6
T14923 26743-26756 VBN denotes ubiquitinated
T14922 26740-26742 TO denotes to
T14921 26730-26739 VBN denotes recruited
T14920 26727-26729 VBZ denotes is
T14919 26723-26726 CC denotes and
T14918 26704-26722 NN denotes osteoclastogenesis
T14917 26690-26703 JJ denotes RANKL-induced
T14916 26687-26689 IN denotes of
T14915 26676-26686 NNS denotes conditions
T14914 26670-26675 IN denotes under
T14913 26658-26669 VBN denotes upregulated
T14912 26649-26657 RB denotes markedly
T14911 26646-26648 VBZ denotes is
T14910 26635-26645 NN denotes expression
T14909 26630-26634 NNP denotes CYLD
T14908 26628-26629 . denotes .
T14907 26617-26628 NNS denotes osteoclasts
T14906 26610-26616 JJR denotes larger
T14905 26606-26609 CC denotes and
T14904 26601-26605 JJR denotes more
T14903 26593-26600 VB denotes produce
T14902 26589-26592 CC denotes and
T14901 26573-26588 NN denotes differentiation
T14900 26559-26572 JJ denotes RANKL-induced
T14899 26556-26558 TO denotes to
T14898 26539-26555 JJ denotes hyper-responsive
T14897 26535-26538 VBP denotes are
T14896 26530-26534 NNS denotes mice
T14895 26524-26529 DT denotes these
T14894 26521-26523 IN denotes of
T14893 26510-26520 NNS denotes precursors
T14832 26133-26134 , denotes ,
T14831 26123-26133 NN denotes signalling
T14830 26117-26122 JJ denotes NF-κB
T14829 26114-26116 IN denotes of
T14828 26107-26113 NNS denotes phases
T14827 26101-26106 RB denotes later
T14826 26091-26100 VBZ denotes regulates
T14825 26084-26090 RB denotes mainly
T14824 26076-26083 NN denotes protein
T14823 26071-26075 DT denotes this
T14822 26066-26070 IN denotes that
T14821 26056-26065 VBN denotes suggested
T14820 26051-26055 VBN denotes been
T14819 26047-26050 VBZ denotes has
T14818 26044-26046 PRP denotes it
T14817 26042-26043 , denotes ,
T14816 26031-26042 NN denotes stimulation
T14815 26026-26030 IN denotes upon
T14814 26020-26025 NNS denotes types
T14813 26015-26019 NN denotes cell
T14812 26010-26014 JJ denotes many
T14811 26007-26009 IN denotes in
T14810 25997-26006 VBN denotes expressed
T14809 25992-25996 RB denotes only
T14808 25989-25991 VBZ denotes is
T14807 25985-25988 NNP denotes A20
T14806 25982-25984 IN denotes As
T14805 25980-25981 . denotes .
T14804 25970-25980 NN denotes activation
T14803 25964-25969 JJ denotes NF-κB
T14802 25956-25963 VB denotes control
T14801 25953-25955 TO denotes to
T14800 25948-25952 NNP denotes CYLD
T14799 25945-25947 IN denotes as
T14798 25940-25944 RB denotes well
T14797 25937-25939 RB denotes as
T14796 25933-25936 NNP denotes A20
T14795 25927-25932 VBZ denotes needs
T14794 25922-25926 NN denotes cell
T14793 25918-25921 DT denotes the
T14792 25914-25917 WRB denotes why
T14791 25908-25913 JJ denotes clear
T14790 25904-25907 RB denotes not
T14789 25898-25903 RB denotes still
T14788 25895-25897 VBZ denotes is
T14787 25892-25894 PRP denotes it
T14786 25888-25891 CC denotes and
T14785 25884-25887 NNP denotes A20
T14784 25881-25883 IN denotes by
T14783 25872-25880 VBN denotes targeted
T14782 25867-25871 RB denotes also
T14781 25863-25866 VBP denotes are
T14780 25857-25862 DT denotes these
T14779 25854-25856 IN denotes of
T14778 25849-25853 JJ denotes Many
T14777 25847-25848 . denotes .
T14776 25843-25847 NNP denotes TAK1
T14775 25839-25842 CC denotes and
T14774 25834-25838 NNP denotes RIP1
T14773 25832-25833 , denotes ,
T14772 25827-25832 NNP denotes TRAF7
T14771 25825-25826 , denotes ,
T14770 25820-25825 NNP denotes TRAF6
T14769 25818-25819 , denotes ,
T14768 25813-25818 NNP denotes TRAF2
T14767 25811-25812 , denotes ,
T14766 25807-25811 NNP denotes NEMO
T14765 25797-25806 VBG denotes including
T14764 25788-25796 NNS denotes proteins
T14763 25777-25787 VBG denotes signalling
T14762 25771-25776 NN denotes NF-κB
T14761 25763-25770 JJ denotes several
T14760 25745-25762 JJ denotes deubiquitina-ting
T14759 25742-25744 IN denotes by
T14758 25740-25741 , denotes ,
T14757 25739-25740 -RRB- denotes )
T14756 25738-25739 CD denotes 1
T14755 25731-25737 NN denotes Figure
T14754 25730-25731 -LRB- denotes (
T14753 25728-25729 -RRB- denotes )
T14752 25727-25728 NNP denotes ]
T14751 25725-25727 CD denotes 64
T14750 25724-25725 NNP denotes [
T14749 25721-25723 IN denotes in
T14748 25712-25720 VBN denotes reviewed
T14747 25711-25712 -LRB- denotes (
T14746 25699-25710 NN denotes stimulation
T14745 25690-25698 NN denotes receptor
T14744 25683-25689 NNP denotes T-cell
T14743 25679-25682 CC denotes and
T14742 25674-25678 NNP denotes RANK
T14741 25672-25673 , denotes ,
T14740 25668-25672 NNP denotes TNFR
T14739 25665-25667 IN denotes by
T14738 25655-25664 VBN denotes initiated
T14737 25644-25654 VBG denotes signalling
T14736 25638-25643 JJ denotes NF-κB
T14735 25628-25637 VBZ denotes regulates
T14734 25617-25627 RB denotes negatively
T14733 25612-25616 IN denotes that
T14732 25605-25611 NN denotes enzyme
T14731 25588-25604 VBG denotes deubiquitinating
T14730 25586-25587 DT denotes a
T14729 25583-25585 VBZ denotes is
T14728 25578-25582 NNP denotes CYLD
T14727 25576-25577 . denotes .
T14726 25575-25576 -RRB- denotes )
T14725 25574-25575 NNP denotes ]
T14724 25572-25574 CD denotes 64
T14723 25571-25572 NNP denotes [
T14722 25568-25570 IN denotes in
T14721 25559-25567 VBN denotes reviewed
T14720 25558-25559 -LRB- denotes (
T14719 25539-25557 NN denotes osteoclastogenesis
T14718 25535-25538 CC denotes and
T14717 25533-25534 , denotes ,
T14716 25518-25533 NN denotes spermatogenesis
T14715 25516-25517 , denotes ,
T14714 25505-25516 NN denotes progression
T14713 25499-25504 NN denotes cycle
T14712 25494-25498 NN denotes cell
T14711 25491-25493 TO denotes to
T14710 25478-25490 NN denotes inflammation
T14709 25474-25477 CC denotes and
T14708 25465-25473 NN denotes immunity
T14707 25460-25464 IN denotes from
T14706 25452-25459 VBG denotes ranging
T14705 25442-25451 NNS denotes processes
T14704 25428-25441 JJ denotes physiological
T14703 25420-25427 JJ denotes diverse
T14702 25417-25419 IN denotes in
T14701 25415-25416 , denotes ,
T14700 25408-25415 RB denotes however
T14699 25406-25407 , denotes ,
T14698 25398-25406 VBN denotes involved
T14697 25393-25397 RB denotes also
T14696 25390-25392 VBZ denotes is
T14695 25385-25389 NNP denotes CYLD
T14694 25383-25384 . denotes .
T14693 25382-25383 NNP denotes ]
T14692 25380-25382 CD denotes 63
T14691 25379-25380 NNP denotes [
T14690 25363-25378 NN denotes cylindromatosis
T14689 25354-25362 JJ denotes familial
T14688 25351-25353 IN denotes in
T14687 25342-25350 VBN denotes involved
T14686 25331-25341 NN denotes suppressor
T14685 25324-25330 NN denotes tumour
T14684 25322-25323 DT denotes a
T14683 25319-25321 IN denotes as
T14682 25308-25318 VBN denotes identified
T14681 25297-25307 RB denotes originally
T14680 25293-25296 VBD denotes was
T14679 25285-25292 NN denotes protein
T14678 25283-25284 -RRB- denotes )
T14677 25279-25283 NNP denotes CYLD
T14676 25278-25279 -LRB- denotes (
T14675 25262-25277 NNP denotes Cylindromatosis
T14674 25254-25261 NN denotes protein
T14673 25238-25253 NNP denotes Cylindromatosis
T14892 26499-26509 NNP denotes Osteoclast
T14891 26497-26498 . denotes .
T14890 26485-26497 NN denotes osteoporosis
T14889 26478-26484 JJ denotes severe
T14888 26470-26477 VB denotes develop
T14887 26466-26469 CC denotes and
T14886 26450-26465 NN denotes differentiation
T14885 26439-26449 NN denotes osteoclast
T14884 26430-26438 JJ denotes aberrant
T14883 26425-26429 VBP denotes have
T14882 26420-26424 NNP denotes CYLD
T14881 26417-26419 IN denotes of
T14880 26406-26416 NN denotes deficiency
T14879 26398-26405 JJ denotes genetic
T14878 26396-26397 DT denotes a
T14877 26391-26395 IN denotes with
T14876 26386-26390 NN denotes Mice
T14875 26384-26385 . denotes .
T14874 26383-26384 NNP denotes ]
T14873 26381-26383 CD denotes 65
T14872 26380-26381 NNP denotes [
T14871 26375-26379 NNS denotes mice
T14870 26372-26374 IN denotes in
T14869 26353-26371 NN denotes osteoclastogenesis
T14868 26349-26352 CC denotes and
T14867 26338-26348 NN denotes signalling
T14866 26333-26337 NNP denotes RANK
T14865 26324-26332 VB denotes regulate
T14864 26313-26323 RB denotes negatively
T14863 26310-26312 TO denotes to
T14862 26304-26309 VBN denotes shown
T14861 26299-26303 VBN denotes been
T14860 26295-26298 VBZ denotes has
T14859 26290-26294 NNP denotes CYLD
T14858 26288-26289 , denotes ,
T14857 26275-26288 RB denotes Interestingly
T14856 26273-26274 . denotes .
T14855 26272-26273 NNP denotes ]
T14854 26270-26272 CD denotes 64
T14853 26269-26270 NNP denotes [
T14852 26259-26268 JJ denotes dependent
T14851 26249-26258 JJ denotes cell-type
T14850 26246-26248 VB denotes be
T14849 26241-26245 RB denotes also
T14848 26235-26240 MD denotes might
T14847 26226-26234 NN denotes activity
T14846 26217-26225 JJ denotes relative
T14845 26211-26216 PRP$ denotes their
T14844 26209-26210 , denotes ,
T14843 26201-26209 NN denotes addition
T14842 26198-26200 IN denotes In
T14841 26196-26197 . denotes .
T14840 26186-26196 NN denotes signalling
T14839 26180-26185 JJ denotes early
T14838 26176-26179 CC denotes and
T14837 26163-26175 JJ denotes constitutive
T14836 26154-26162 VB denotes regulate
T14835 26148-26153 MD denotes would
T14834 26143-26147 NNP denotes CYLD
T14833 26135-26142 IN denotes whereas
T13604 25235-25236 . denotes .
T13603 25233-25235 NNP denotes RA
T13602 25228-25232 IN denotes with
T13601 25217-25227 VBN denotes associated
T13600 25212-25216 RB denotes also
T13599 25208-25211 VBP denotes are
T13598 25194-25207 NNS denotes erythematosus
T13597 25188-25193 NN denotes lupus
T13596 25179-25187 JJ denotes systemic
T13595 25174-25178 IN denotes with
T13594 25163-25173 VBN denotes associated
T13593 25160-25162 VB denotes be
T13592 25157-25159 TO denotes to
T13591 25148-25156 VBN denotes reported
T13590 25143-25147 VBN denotes been
T13589 25138-25142 VBP denotes have
T13588 25133-25137 WDT denotes that
T13587 25128-25132 NNS denotes SNPs
T13586 25120-25127 IN denotes whether
T13585 25108-25119 VB denotes investigate
T13584 25105-25107 TO denotes to
T13583 25093-25104 JJ denotes interesting
T13582 25090-25092 VB denotes be
T13581 25080-25089 RB denotes therefore
T13580 25075-25079 MD denotes will
T13579 25072-25074 PRP denotes It
T13578 25070-25071 . denotes .
T13577 25069-25070 -RRB- denotes )
T13576 25060-25069 NN denotes rituximab
T13575 25059-25060 -LRB- denotes (
T13574 25049-25058 NN denotes depletion
T13573 25042-25048 NNP denotes B-cell
T13572 25039-25041 IN denotes as
T13571 25034-25038 JJ denotes such
T13570 25023-25033 NNS denotes treatments
T13569 25020-25022 TO denotes to
T13568 25011-25019 NN denotes response
T13567 25007-25010 CC denotes and
T13566 24998-25006 NNS denotes features
T13565 24989-24997 JJ denotes systemic
T13564 24987-24988 , denotes ,
T13563 24977-24987 NN denotes production
T13562 24964-24976 JJ denotes autoantibody
T13390 23932-23936 NNS denotes mice
T13389 23922-23931 JJ denotes deficient
T13388 23915-23921 NNP denotes ABIN-1
T13387 23911-23914 CC denotes and
T13386 23909-23910 , denotes ,
T13385 23908-23909 NNP denotes ]
T13384 23906-23908 CD denotes 58
T13383 23905-23906 NNP denotes [
T13382 23895-23904 NN denotes apoptosis
T13381 23883-23894 JJ denotes TNF-induced
T13380 23874-23882 VBZ denotes inhibits
T13379 23865-23873 RB denotes strongly
T13378 23860-23864 RB denotes also
T13377 23853-23859 NNP denotes ABIN-1
T13376 23851-23852 , denotes ,
T13375 23848-23851 NNP denotes A20
T13374 23844-23847 IN denotes for
T13373 23841-23843 IN denotes As
T13372 23839-23840 . denotes .
T13371 23838-23839 NNP denotes ]
T13370 23836-23838 CD denotes 57
T13369 23835-23836 NNP denotes [
T13368 23828-23834 NN denotes domain
T13367 23810-23827 JJ denotes ubiquitin-binding
T13366 23802-23809 JJ denotes crucial
T13365 23798-23801 DT denotes the
T13364 23790-23797 VBG denotes lacking
T13363 23785-23789 NN denotes form
T13362 23776-23784 JJ denotes inactive
T13361 23772-23775 CC denotes and
T13360 23762-23771 VBN denotes truncated
T13359 23760-23761 DT denotes a
T13358 23752-23759 VB denotes express
T13357 23747-23751 RB denotes only
T13356 23742-23746 NNS denotes mice
T13355 23738-23741 CC denotes but
T13354 23736-23737 , denotes ,
T13353 23730-23736 NNS denotes humans
T13352 23727-23729 IN denotes in
T13351 23717-23726 VBN denotes expressed
T13350 23714-23716 VBZ denotes is
T13349 23707-23713 NNP denotes ABIN-3
T13348 23696-23706 NNP denotes Functional
T13347 23694-23695 . denotes .
T13346 23693-23694 NNP denotes ]
T13345 23688-23693 CD denotes 55,56
T13344 23687-23688 NNP denotes [
T13343 23681-23686 NNP denotes ABINs
T13342 23672-23680 JJ denotes multiple
T13341 23669-23671 IN denotes of
T13340 23658-23668 NNS denotes activities
T13339 23647-23657 NN denotes inhibitory
T13338 23641-23646 NN denotes NF-κB
T13337 23631-23640 JJ denotes redundant
T13336 23620-23630 VBG denotes reflecting
T13335 23611-23619 RB denotes possibly
T13334 23609-23610 , denotes ,
T13333 23597-23609 RB denotes respectively
T13332 23595-23596 , denotes ,
T13331 23586-23595 NNS denotes responses
T13330 23580-23585 NN denotes NF-κB
T13329 23573-23579 JJ denotes normal
T13328 23570-23572 CC denotes or
T13327 23560-23569 VBN denotes increased
T13326 23551-23559 RB denotes slightly
T13325 23546-23550 RB denotes only
T13324 23538-23545 VBP denotes exhibit
T13323 23533-23537 NNS denotes mice
T13322 23516-23532 JJ denotes ABIN-2-deficient
T13321 23512-23515 CC denotes and
T13320 23495-23511 JJ denotes ABIN-1-deficient
T13319 23490-23494 DT denotes both
T13318 23488-23489 , denotes ,
T13317 23476-23488 RB denotes Unexpectedly
T13316 23474-23475 . denotes .
T13315 23473-23474 -RRB- denotes )
T13314 23472-23473 NNP denotes ]
T13313 23470-23472 CD denotes 54
T13312 23469-23470 NNP denotes [
T13311 23466-23468 IN denotes in
T13310 23457-23465 VBN denotes reviewed
T13309 23456-23457 -LRB- denotes (
T13308 23445-23455 NN denotes activation
T13307 23439-23444 JJ denotes NF-κB
T13306 23436-23438 IN denotes of
T13305 23425-23435 NN denotes regulation
T13304 23416-23424 NN denotes feedback
T13303 23407-23415 JJ denotes negative
T13302 23403-23406 DT denotes the
T13301 23400-23402 IN denotes in
T13300 23392-23399 NN denotes complex
T13299 23383-23391 NNP denotes A20/ABIN
T13298 23379-23382 DT denotes the
T13297 23375-23378 IN denotes for
T13296 23370-23374 NN denotes role
T13295 23360-23369 JJ denotes potential
T13294 23358-23359 DT denotes a
T13293 23346-23357 VBG denotes implicating
T13292 23344-23345 , denotes ,
T13291 23335-23344 JJ denotes dependent
T13290 23329-23334 JJ denotes NF-κB
T13289 23326-23328 VBZ denotes is
T13288 23315-23325 NN denotes expression
T13287 23308-23314 NNP denotes ABIN-3
T13286 23304-23307 CC denotes and
T13285 23297-23303 NNP denotes ABIN-1
T13284 23295-23296 , denotes ,
T13283 23292-23295 NNP denotes A20
T13282 23289-23291 TO denotes to
T13281 23281-23288 JJ denotes Similar
T13280 23279-23280 . denotes .
T13279 23278-23279 NNP denotes ]
T13278 23273-23278 CD denotes 43,44
T13277 23272-23273 NNP denotes [
T13276 23261-23271 NNS denotes substrates
T13275 23243-23260 VBN denotes polyubiquitinated
T13274 23240-23242 TO denotes to
T13273 23236-23239 CD denotes A20
T13272 23229-23235 VB denotes target
T13271 23226-23228 TO denotes to
T13270 23217-23225 VBN denotes proposed
T13269 23212-23216 VBN denotes been
T13268 23207-23211 VBP denotes have
T13267 23202-23206 PRP denotes they
T13266 23200-23201 , denotes ,
T13265 23195-23200 NN denotes motif
T13264 23177-23194 JJ denotes ubiquitin-binding
T13263 23168-23176 JJ denotes specific
T13262 23166-23167 DT denotes a
T13261 23158-23165 VBP denotes contain
T13260 23152-23157 NNP denotes ABINs
T13259 23144-23151 IN denotes Because
T13258 23142-23143 . denotes .
T13257 23128-23142 NN denotes overexpression
T13256 23123-23127 IN denotes upon
T13255 23115-23122 NNS denotes stimuli
T13254 23102-23114 JJ denotes inflammatory
T13253 23096-23101 JJ denotes other
T13252 23088-23095 JJ denotes several
T13251 23084-23087 CC denotes and
T13250 23080-23083 NNP denotes TNF
T13249 23077-23079 IN denotes by
T13248 23066-23076 NN denotes activation
T13247 23060-23065 JJ denotes NF-κB
T13246 23052-23059 VB denotes inhibit
T13245 23049-23051 TO denotes to
T13244 23043-23048 VBN denotes shown
T13243 23038-23042 VBD denotes were
T13242 23034-23037 CC denotes and
T13241 23025-23033 NNS denotes proteins
T13240 23013-23024 VBG denotes interacting
T13239 23009-23012 NNP denotes A20
T13238 22999-23008 VBN denotes expressed
T13237 22986-22998 RB denotes ubiquitously
T13236 22983-22985 IN denotes as
T13235 22972-22982 VBN denotes identified
T13234 22967-22971 VBD denotes were
T13233 22965-22966 -RRB- denotes )
T13232 22959-22965 NNP denotes TNIP-3
T13231 22955-22958 CC denotes and
T13230 22953-22954 , denotes ,
T13229 22947-22953 CD denotes TNIP-2
T13228 22945-22946 , denotes ,
T13227 22939-22945 CD denotes TNIP-1
T13226 22936-22938 IN denotes as
T13225 22930-22935 VBN denotes known
T13224 22925-22929 RB denotes also
T13223 22924-22925 -LRB- denotes (
T13222 22917-22923 NNP denotes ABIN-3
T13221 22913-22916 CC denotes and
T13220 22906-22912 NNP denotes ABIN-2
T13219 22904-22905 , denotes ,
T13218 22898-22904 NNP denotes ABIN-1
T13217 22892-22897 NNP denotes NF-κB
T13216 22889-22891 IN denotes of
T13215 22878-22888 NNS denotes inhibitors
T13214 22866-22877 JJ denotes A20-binding
T13561 24962-24963 , denotes ,
T13560 24951-24962 NN denotes involvement
T13559 24945-24950 JJ denotes joint
T13558 24942-24944 IN denotes in
T13557 24934-24941 VBP denotes overlap
T13556 24925-24933 JJ denotes clinical
T13555 24920-24924 DT denotes some
T13553 24906-24914 NNS denotes diseases
T13552 24902-24905 CD denotes two
T13551 24898-24901 DT denotes the
T13550 24895-24897 IN denotes as
T13549 24886-24894 VBN denotes expected
T13548 24883-24885 VB denotes be
T13547 24877-24882 MD denotes might
T13546 24872-24876 NN denotes loci
T13545 24857-24871 NN denotes susceptibility
T13544 24854-24856 NNP denotes RA
T13543 24850-24853 CC denotes and
T13542 24836-24849 NNS denotes erythematosus
T13541 24830-24835 NN denotes lupus
T13540 24821-24829 JJ denotes systemic
T13539 24813-24820 IN denotes between
T13538 24805-24812 VBP denotes overlap
T13537 24802-24804 IN denotes of
T13536 24795-24801 NN denotes degree
T13535 24790-24794 JJ denotes high
T13534 24788-24789 DT denotes A
T13533 24786-24787 . denotes .
T13532 24785-24786 NNP denotes ]
T13531 24780-24785 CD denotes 61,62
T13530 24779-24780 NNP denotes [
T13529 24772-24778 NNS denotes humans
T13528 24769-24771 IN denotes in
T13527 24755-24768 VBZ denotes erythematosus
T13526 24749-24754 NN denotes lupus
T13525 24740-24748 JJ denotes systemic
T13524 24736-24739 CC denotes and
T13523 24726-24735 NN denotes psoriasis
T13522 24721-24725 IN denotes with
T13521 24710-24720 VBN denotes associated
T13520 24705-24709 VBN denotes been
T13519 24700-24704 VBP denotes have
T13518 24686-24699 NNS denotes polymorphisms
T13517 24679-24685 JJ denotes ABIN-1
T13516 24677-24678 , denotes ,
T13515 24664-24677 RB denotes Interestingly
T13514 24662-24663 . denotes .
T13513 24661-24662 NNP denotes ]
T13512 24659-24661 CD denotes 60
T13511 24658-24659 NNP denotes [
T13510 24646-24657 NNS denotes macrophages
T13509 24637-24645 JJ denotes synovial
T13508 24627-24636 NNS denotes arthritis
T13507 24614-24626 JJ denotes inflammatory
T13506 24611-24613 IN denotes in
T13505 24600-24610 VBN denotes suppressed
T13504 24591-24599 RB denotes strongly
T13503 24587-24590 VBD denotes was
T13502 24582-24586 NNP denotes ITAM
T13501 24578-24581 DT denotes the
T13500 24575-24577 IN denotes of
T13499 24568-24574 NN denotes effect
T13498 24557-24567 JJ denotes protective
T13497 24552-24556 DT denotes this
T13496 24550-24551 , denotes ,
T13495 24542-24550 RB denotes Moreover
T13494 24540-24541 . denotes .
T13493 24537-24540 NNP denotes A20
T13492 24533-24536 CC denotes and
T13491 24526-24532 JJ denotes ABIN-3
T13490 24517-24525 NNS denotes proteins
T13489 24506-24516 NN denotes inhibitory
T13488 24500-24505 JJ denotes NF-κB
T13487 24496-24499 DT denotes the
T13486 24493-24495 IN denotes of
T13485 24482-24492 NN denotes expression
T13484 24478-24481 DT denotes the
T13483 24475-24477 IN denotes on
T13482 24468-24474 VB denotes depend
T13481 24465-24467 TO denotes to
T13480 24459-24464 VBN denotes shown
T13479 24455-24458 VBD denotes was
T13478 24445-24454 NNS denotes receptors
T13477 24437-24444 VBN denotes coupled
T13476 24436-24437 : denotes -
T13475 24435-24436 -RRB- denotes )
T13474 24431-24435 NNP denotes ITAM
T13473 24430-24431 -LRB- denotes (
T13472 24424-24429 NN denotes motif
T13471 24413-24423 NN denotes activation
T13470 24398-24412 JJ denotes tyrosine-based
T13469 24383-24397 JJ denotes immunoreceptor
T13468 24380-24382 IN denotes by
T13467 24370-24379 NNS denotes responses
T13466 24366-24369 NNP denotes TLR
T13465 24363-24365 IN denotes of
T13464 24352-24362 NN denotes inhibition
T13463 24350-24351 , denotes ,
T13462 24345-24350 NN denotes study
T13461 24338-24344 JJ denotes recent
T13460 24336-24337 DT denotes a
T13459 24333-24335 IN denotes In
T13458 24331-24332 . denotes .
T13457 24330-24331 NNP denotes ]
T13456 24328-24330 CD denotes 59
T13455 24327-24328 NNP denotes [
T13454 24324-24326 NNP denotes RA
T13453 24321-24323 IN denotes of
T13452 24308-24320 NN denotes pathogenesis
T13451 24304-24307 DT denotes the
T13450 24300-24303 CC denotes and
T13449 24289-24299 NN denotes signalling
T13448 24283-24288 JJ denotes NF-κB
T13447 24280-24282 IN denotes of
T13446 24269-24279 NN denotes regulation
T13445 24260-24268 NN denotes feedback
T13444 24251-24259 JJ denotes negative
T13443 24247-24250 DT denotes the
T13442 24244-24246 IN denotes in
T13441 24242-24243 , denotes ,
T13440 24239-24242 NNP denotes A20
T13439 24234-24238 IN denotes with
T13438 24225-24233 RB denotes together
T13437 24223-24224 , denotes ,
T13436 24217-24223 NNP denotes ABIN-1
T13435 24213-24216 IN denotes for
T13434 24208-24212 NN denotes role
T13433 24198-24207 JJ denotes potential
T13432 24196-24197 DT denotes a
T13431 24185-24195 VBG denotes indicating
T13430 24183-24184 , denotes ,
T13429 24175-24183 NNS denotes biopsies
T13428 24168-24174 NN denotes tissue
T13427 24165-24167 NNP denotes RA
T13426 24162-24164 IN denotes in
T13425 24153-24161 VBN denotes detected
T13424 24148-24152 VBD denotes were
T13423 24143-24147 NNP denotes mRNA
T13422 24136-24142 NNP denotes ABIN-1
T13421 24133-24135 IN denotes of
T13420 24126-24132 NNS denotes levels
T13419 24121-24125 JJ denotes high
T13418 24117-24120 CC denotes and
T13417 24115-24116 , denotes ,
T13416 24103-24115 NNS denotes synoviocytes
T13415 24097-24102 JJ denotes human
T13414 24094-24096 IN denotes in
T13413 24088-24093 NNS denotes genes
T13412 24076-24087 JJ denotes TNF-induced
T13411 24070-24075 IN denotes among
T13410 24059-24069 VBN denotes identified
T13409 24055-24058 VBD denotes was
T13408 24048-24054 NN denotes ABIN-1
T13407 24046-24047 , denotes ,
T13406 24038-24046 NN denotes analysis
T13405 24027-24037 NN denotes microarray
T13404 24011-24026 NN denotes oligonucleotide
T13403 24005-24010 VBG denotes Using
T13402 24003-24004 . denotes .
T13401 24002-24003 NNP denotes ]
T13400 24000-24002 CD denotes 56
T13399 23999-24000 NNP denotes [
T13398 23989-23998 NN denotes apoptosis
T13397 23983-23988 NN denotes liver
T13396 23976-23982 JJ denotes foetal
T13395 23962-23975 JJ denotes TNF-dependent
T13394 23959-23961 TO denotes to
T13393 23955-23958 JJ denotes due
T13392 23941-23954 RB denotes embryonically
T13391 23937-23940 VBP denotes die
T11686 22863-22864 . denotes .
T11685 22858-22863 NNS denotes tools
T11684 22849-22857 JJ denotes valuable
T11683 22844-22848 RB denotes very
T11682 22841-22843 VB denotes be
T11681 22836-22840 MD denotes will
T11680 22834-22835 , denotes ,
T11679 22832-22834 NNP denotes RA
T11678 22828-22831 IN denotes for
T11677 22821-22827 NNS denotes models
T11676 22815-22820 NN denotes mouse
T11675 22810-22814 IN denotes with
T11674 22801-22809 VBN denotes combined
T11673 22799-22800 , denotes ,
T11672 22795-22799 NNS denotes SNPs
T11671 22791-22794 NNP denotes A20
T11670 22777-22790 JJ denotes corresponding
T11669 22773-22776 DT denotes the
T11668 22769-22772 IN denotes for
T11667 22764-22768 NNS denotes mice
T11666 22756-22763 FW denotes knockin
T11665 22754-22755 , denotes ,
T11664 22747-22754 NN denotes context
T11663 22742-22746 DT denotes this
T11662 22739-22741 IN denotes In
T11661 22737-22738 . denotes .
T11660 22729-22737 NNS denotes variants
T11659 22723-22728 DT denotes these
T11658 22720-22722 IN denotes of
T11657 22707-22719 NNS denotes consequences
T11656 22696-22706 JJ denotes functional
T11655 22692-22695 DT denotes the
T11654 22682-22691 VB denotes elucidate
T11653 22679-22681 TO denotes to
T11652 22675-22678 CC denotes and
T11651 22666-22674 NNS denotes variants
T11650 22659-22665 JJ denotes causal
T11649 22652-22658 JJ denotes actual
T11648 22648-22651 DT denotes the
T11647 22639-22647 VB denotes identify
T11646 22636-22638 TO denotes to
T11645 22627-22635 NN denotes interest
T11644 22624-22626 IN denotes of
T11643 22621-22623 VB denotes be
T11642 22616-22620 MD denotes will
T11641 22613-22615 PRP denotes It
T11640 22611-22612 . denotes .
T11639 22610-22611 NNP denotes ]
T11638 22608-22610 CD denotes 53
T11637 22607-22608 NNP denotes [
T11636 22594-22606 VBD denotes investigated
T11635 22589-22593 NNS denotes SNPs
T11634 22585-22588 DT denotes the
T11633 22582-22584 IN denotes of
T11632 22577-22581 DT denotes some
T11631 22573-22576 IN denotes for
T11630 22559-22572 NN denotes transcription
T11629 22555-22558 NNP denotes A20
T11628 22545-22554 JJ denotes repressed
T11627 22540-22544 VB denotes show
T11626 22534-22539 MD denotes could
T11625 22530-22533 CC denotes and
T11624 22528-22529 , denotes ,
T11623 22520-22528 NN denotes activity
T11622 22511-22519 NN denotes promoter
T11621 22507-22510 NNP denotes A20
T11620 22504-22506 IN denotes on
T11619 22495-22503 NNS denotes variants
T11618 22491-22494 NNP denotes SNP
T11617 22477-22490 JJ denotes RA-associated
T11616 22474-22476 IN denotes of
T11615 22466-22473 NN denotes ability
T11614 22455-22465 JJ denotes regulatory
T11613 22451-22454 DT denotes the
T11612 22445-22450 NN denotes vitro
T11611 22442-22444 IN denotes in
T11610 22432-22441 VBN denotes evaluated
T11609 22419-22431 RB denotes functionally
T11608 22408-22418 NNS denotes colleagues
T11607 22404-22407 CC denotes and
T11606 22398-22403 NNP denotes Elsby
T11605 22396-22397 , denotes ,
T11604 22388-22396 RB denotes Recently
T11603 22386-22387 . denotes .
T11602 22379-22386 JJ denotes unclear
T11601 22372-22378 VBP denotes remain
T11600 22370-22371 , denotes ,
T11599 22363-22370 RB denotes however
T11598 22361-22362 , denotes ,
T11597 22359-22361 NNP denotes RA
T11596 22353-22358 VBP denotes cause
T11595 22348-22352 PRP denotes they
T11594 22344-22347 WRB denotes how
T11593 22340-22343 CC denotes and
T11592 22331-22339 NN denotes activity
T11591 22327-22330 JJ denotes A20
T11590 22320-22326 JJ denotes normal
T11589 22313-22319 VBP denotes affect
T11588 22304-22312 NNS denotes variants
T11587 22298-22303 DT denotes these
T11586 22294-22297 WRB denotes How
T11585 22292-22293 . denotes .
T11584 22290-22292 NNP denotes RA
T11583 22286-22289 IN denotes for
T11582 22280-22285 NN denotes locus
T11581 22265-22279 NN denotes susceptibility
T11580 22255-22264 NN denotes candidate
T11579 22253-22254 DT denotes a
T11578 22250-22252 IN denotes as
T11577 22246-22249 NNP denotes A20
T11576 22239-22245 VBP denotes reveal
T11575 22230-22238 NNS denotes findings
T11574 22224-22229 DT denotes these
T11573 22222-22223 , denotes ,
T11572 22220-22222 NNP denotes RA
T11571 22217-22219 IN denotes in
T11570 22208-22216 NN denotes cytokine
T11569 22195-22207 JJ denotes inflammatory
T11568 22187-22194 JJ denotes primary
T11567 22183-22186 DT denotes the
T11566 22180-22182 VBZ denotes is
T11565 22176-22179 NNP denotes TNF
T11564 22172-22175 CC denotes and
T11563 22170-22171 , denotes ,
T11562 22163-22170 NNS denotes signals
T11561 22151-22162 JJ denotes TNF-induced
T11560 22148-22150 IN denotes of
T11559 22136-22147 NN denotes termination
T11558 22132-22135 IN denotes for
T11557 22123-22131 VBN denotes required
T11556 22120-22122 VBZ denotes is
T11555 22116-22119 NNP denotes A20
T11554 22113-22115 IN denotes As
T11417 21349-21357 NN denotes activity
T11416 21345-21348 CC denotes and
T11415 21338-21344 NN denotes number
T11414 21327-21337 JJ denotes osteoclast
T11413 21323-21326 DT denotes the
T11412 21312-21322 VBG denotes decreasing
T11411 21304-21311 IN denotes through
T11410 21292-21303 NN denotes destruction
T11409 21286-21291 JJ denotes joint
T11408 21277-21285 VB denotes minimise
T11407 21267-21276 RB denotes therefore
T11406 21261-21266 MD denotes might
T11405 21257-21260 RB denotes A20
T11404 21255-21256 . denotes .
T11403 21249-21255 NN denotes tissue
T11402 21243-21248 JJ denotes joint
T11401 21240-21242 IN denotes in
T11400 21228-21239 NNS denotes osteoclasts
T11399 21218-21227 VBN denotes activated
T11398 21215-21217 IN denotes of
T11397 21208-21214 NN denotes number
T11396 21204-21207 DT denotes the
T11395 21201-21203 IN denotes in
T11394 21192-21200 NN denotes decrease
T11393 21190-21191 DT denotes a
T11392 21187-21189 TO denotes to
T11391 21181-21186 VBZ denotes leads
T11390 21166-21180 NN denotes overexpression
T11389 21162-21165 CD denotes A20
T11388 21157-21161 IN denotes that
T11387 21144-21156 VBD denotes demonstrated
T11386 21139-21143 RB denotes also
T11385 21133-21138 NN denotes study
T11384 21128-21132 DT denotes This
T11383 21126-21127 . denotes .
T11382 21118-21126 NNS denotes findings
T11381 21105-21117 JJ denotes radiological
T11380 21101-21104 CC denotes and
T11379 21099-21100 , denotes ,
T11378 21087-21099 JJ denotes pathological
T11377 21085-21086 , denotes ,
T11376 21077-21085 JJ denotes clinical
T11375 21073-21076 DT denotes the
T11374 21070-21072 IN denotes in
T11373 21062-21069 NNS denotes effects
T11372 21051-21061 JJ denotes beneficial
T11371 21047-21050 DT denotes the
T11370 21039-21046 VB denotes explain
T11369 21033-21038 MD denotes might
T11368 21028-21032 NNS denotes mice
T11367 21013-21027 JJ denotes A20-transduced
T11366 21010-21012 IN denotes in
T11365 21004-21009 NNP denotes IL-1β
T11364 21000-21003 CC denotes and
T11363 20996-20999 NNP denotes TNF
T11362 20993-20995 IN denotes of
T11361 20986-20992 NNS denotes levels
T11360 20980-20985 NN denotes serum
T11359 20970-20979 VBN denotes decreased
T11358 20966-20969 DT denotes the
T11357 20964-20965 , denotes ,
T11356 20962-20964 NNP denotes RA
T11355 20959-20961 IN denotes in
T11354 20954-20958 NN denotes bone
T11353 20950-20953 CC denotes and
T11352 20940-20949 NN denotes cartilage
T11351 20937-20939 IN denotes of
T11350 20929-20936 NN denotes erosion
T11349 20925-20928 CC denotes and
T11348 20923-20924 , denotes ,
T11347 20914-20923 NN denotes formation
T11346 20907-20913 NN denotes pannus
T11345 20905-20906 , denotes ,
T11344 20896-20905 NNS denotes synovitis
T11343 20888-20895 VB denotes mediate
T11342 20885-20887 TO denotes to
T11341 20879-20884 VBN denotes known
T11340 20875-20878 VBP denotes are
T11339 20869-20874 NNP denotes IL-1β
T11338 20865-20868 CC denotes and
T11337 20861-20864 NNP denotes TNF
T11336 20853-20860 IN denotes Because
T11335 20851-20852 . denotes .
T11334 20850-20851 NNP denotes ]
T11333 20848-20850 CD denotes 51
T11332 20847-20848 NNP denotes [
T11331 20836-20846 NN denotes expression
T11330 20831-20835 NN denotes gene
T11329 20818-20830 JJ denotes κB-dependent
T11328 20816-20817 : denotes -
T11327 20814-20816 SYM denotes NF
T11326 20810-20813 CC denotes and
T11325 20799-20809 NN denotes activation
T11324 20793-20798 JJ denotes NF-κB
T11323 20790-20792 IN denotes of
T11322 20778-20789 NN denotes suppression
T11321 20770-20777 IN denotes through
T11320 20765-20769 NNS denotes mice
T11319 20755-20764 NNS denotes arthritis
T11318 20738-20754 JJ denotes collagen-induced
T11317 20735-20737 IN denotes in
T11316 20728-20734 NN denotes effect
T11315 20717-20727 JJ denotes protective
T11314 20715-20716 DT denotes a
T11313 20707-20714 VBZ denotes induces
T11312 20703-20706 NNP denotes A20
T11311 20698-20702 IN denotes that
T11310 20687-20697 VBG denotes suggesting
T11309 20685-20686 , denotes ,
T11308 20680-20685 NNP denotes IL-17
T11307 20676-20679 CC denotes and
T11306 20674-20675 , denotes ,
T11305 20673-20674 CD denotes 1
T11304 20665-20672 NN denotes protein
T11303 20648-20664 JJ denotes chemo-attractant
T11302 20639-20647 JJ denotes monocyte
T11301 20637-20638 , denotes ,
T11300 20632-20637 NNP denotes RANKL
T11299 20624-20631 JJ denotes soluble
T11298 20622-20623 , denotes ,
T11297 20618-20622 NNP denotes IL-6
T11296 20616-20617 , denotes ,
T11295 20611-20616 NNP denotes IL-1β
T11294 20609-20610 , denotes ,
T11293 20606-20609 NNP denotes TNF
T11292 20603-20605 IN denotes of
T11291 20596-20602 NNS denotes levels
T11290 20586-20595 VBD denotes decreased
T11289 20582-20585 CC denotes and
T11288 20573-20581 NN denotes activity
T11287 20567-20572 JJ denotes NF-κB
T11286 20564-20566 IN denotes of
T11285 20553-20563 NN denotes inhibition
T11284 20548-20552 IN denotes with
T11283 20537-20547 VBN denotes associated
T11282 20533-20536 VBD denotes was
T11281 20526-20532 NN denotes tissue
T11280 20517-20525 JJ denotes synovial
T11279 20514-20516 IN denotes in
T11278 20503-20513 NN denotes expression
T11277 20499-20502 CD denotes A20
T11276 20497-20498 . denotes .
T11275 20490-20497 NN denotes setting
T11274 20478-20489 JJ denotes therapeutic
T11273 20474-20477 CC denotes and
T11272 20461-20473 NN denotes prophylactic
T11271 20459-20460 DT denotes a
T11270 20454-20458 DT denotes both
T11269 20451-20453 IN denotes in
T11268 20449-20450 , denotes ,
T11267 20443-20449 NNS denotes joints
T11266 20433-20442 JJ denotes untreated
T11265 20430-20432 IN denotes in
T11264 20425-20429 RB denotes even
T11263 20423-20424 , denotes ,
T11262 20414-20423 NNS denotes arthritis
T11261 20397-20413 JJ denotes collagen-induced
T11260 20394-20396 IN denotes of
T11259 20388-20393 NN denotes model
T11258 20382-20387 NN denotes mouse
T11257 20380-20381 DT denotes a
T11256 20377-20379 IN denotes in
T11255 20365-20376 NN denotes destruction
T11254 20359-20364 JJ denotes joint
T11253 20355-20358 CC denotes and
T11252 20342-20354 NN denotes inflammation
T11251 20333-20341 JJ denotes synovial
T11250 20330-20332 IN denotes of
T11249 20321-20329 NN denotes severity
T11248 20317-20320 DT denotes the
T11247 20310-20316 VB denotes reduce
T11246 20307-20309 TO denotes to
T11245 20301-20306 VBN denotes shown
T11244 20297-20300 VBD denotes was
T11243 20286-20296 NN denotes adenovirus
T11242 20271-20285 JJ denotes A20-expressing
T11241 20268-20270 DT denotes an
T11240 20265-20267 IN denotes of
T11239 20255-20264 NN denotes injection
T11238 20239-20254 JJ denotes intra-articular
T11237 20237-20238 , denotes ,
T11236 20229-20237 RB denotes Recently
T11235 20227-20228 . denotes .
T11234 20217-20227 NN denotes signalling
T11233 20211-20216 JJ denotes NF-κB
T11232 20208-20210 IN denotes of
T11231 20197-20207 NN denotes regulation
T11230 20188-20196 NN denotes feedback
T11229 20179-20187 JJ denotes negative
T11228 20175-20178 DT denotes the
T11227 20172-20174 IN denotes in
T11226 20168-20171 NNP denotes A20
T11225 20156-20167 VBG denotes implicating
T11224 20154-20155 , denotes ,
T11223 20153-20154 NNP denotes ]
T11222 20151-20153 CD denotes 50
T11221 20150-20151 NNP denotes [
T11220 20144-20149 NNP denotes NF-κB
T11219 20141-20143 IN denotes by
T11218 20131-20140 VBN denotes regulated
T11217 20124-20130 PRP denotes itself
T11216 20121-20123 VBZ denotes is
T11215 20110-20120 NN denotes expression
T11214 20106-20109 NNP denotes A20
T11213 20104-20105 , denotes ,
T11212 20091-20104 RB denotes Interestingly
T11211 20089-20090 . denotes .
T11210 20078-20089 NNS denotes lymphocytes
T11209 20074-20077 CC denotes and
T11208 20061-20073 NNS denotes synoviocytes
T11207 20059-20060 , denotes ,
T11206 20048-20059 NNS denotes fibroblasts
T11205 20045-20047 IN denotes as
T11204 20040-20044 JJ denotes such
T11203 20038-20039 , denotes ,
T11202 20036-20038 NNP denotes RA
T11193 19978-19983 NNS denotes types
T11192 19973-19977 NN denotes cell
T11191 19965-19972 JJ denotes several
T11190 19962-19964 IN denotes in
T11189 19953-19961 VBN denotes observed
T11188 19948-19952 VBN denotes been
T11187 19944-19947 VBZ denotes has
T11186 19933-19943 NN denotes expression
T11185 19929-19932 CD denotes A20
T11184 19927-19928 . denotes .
T11183 19926-19927 NNP denotes ]
T11182 19921-19926 CD denotes 48,49
T11181 19920-19921 NNP denotes [
T11180 19911-19919 NN denotes survival
T11179 19904-19910 NN denotes B-cell
T11178 19891-19903 JJ denotes unrestricted
T11177 19888-19890 TO denotes to
T11176 19880-19887 VBG denotes leading
T11175 19874-19879 NNS denotes cells
T11174 19872-19873 NNP denotes B
T11173 19869-19871 IN denotes in
T11172 19859-19868 NNS denotes responses
T11171 19853-19858 NN denotes NF-κB
T11170 19841-19852 JJ denotes hyperactive
T11169 19838-19840 TO denotes to
T11168 19834-19837 JJ denotes due
T11167 19821-19833 NN denotes autoimmunity
T11166 19813-19820 VBP denotes develop
T11165 19807-19812 NNS denotes cells
T11164 19805-19806 NNP denotes B
T11163 19802-19804 IN denotes in
T11162 19798-19801 NNP denotes A20
T11161 19790-19797 VBG denotes lacking
T11160 19785-19789 NNS denotes mice
T11159 19780-19784 IN denotes that
T11158 19773-19779 VBD denotes showed
T11157 19765-19772 NNS denotes studies
T11156 19753-19764 JJ denotes independent
T11155 19749-19752 CD denotes Two
T11154 19747-19748 . denotes .
T11153 19746-19747 NNP denotes ]
T11152 19744-19746 CD denotes 47
T11151 19743-19744 NNP denotes [
T11150 19732-19742 NN denotes epithelium
T11149 19721-19731 JJ denotes intestinal
T11148 19717-19720 DT denotes the
T11147 19714-19716 IN denotes in
T11146 19706-19713 NN denotes protein
T11145 19692-19705 JJ denotes antiapoptotic
T11144 19686-19691 JJ denotes major
T11143 19684-19685 DT denotes a
T11142 19681-19683 IN denotes as
T11141 19677-19680 NNP denotes A20
T11140 19666-19676 VBG denotes confirming
T11139 19664-19665 , denotes ,
T11138 19655-19664 NN denotes apoptosis
T11137 19643-19654 JJ denotes TNF-induced
T11136 19640-19642 TO denotes to
T11135 19634-19639 NNS denotes cells
T11134 19623-19633 JJ denotes epithelial
T11133 19612-19622 JJ denotes intestinal
T11132 19606-19611 PRP$ denotes their
T11131 19603-19605 IN denotes of
T11130 19586-19602 NN denotes hypersensitivity
T11129 19582-19585 DT denotes the
T11128 19579-19581 TO denotes to
T11127 19575-19578 JJ denotes due
T11126 19567-19574 NNS denotes colitis
T11125 19554-19566 JJ denotes experimental
T11124 19551-19553 TO denotes to
T11123 19536-19550 NN denotes susceptibility
T11122 19526-19535 VBN denotes increased
T11121 19518-19525 VBP denotes exhibit
T11120 19512-19517 NNS denotes cells
T11119 19501-19511 JJ denotes epithelial
T11118 19490-19500 JJ denotes intestinal
T11117 19487-19489 IN denotes in
T11116 19483-19486 NNP denotes A20
T11115 19475-19482 VBG denotes lacking
T11114 19462-19474 RB denotes specifically
T11113 19457-19461 NNS denotes mice
T11112 19452-19456 IN denotes that
T11111 19445-19451 VBD denotes showed
T11110 19436-19444 RB denotes recently
T11109 19433-19435 PRP denotes We
T11108 19431-19432 . denotes .
T11107 19424-19431 NN denotes protein
T11106 19410-19423 JJ denotes antiapoptotic
T11105 19407-19409 DT denotes an
T11104 19404-19406 IN denotes as
T11103 19399-19403 NN denotes role
T11102 19395-19398 PRP$ denotes its
T11101 19384-19394 VBG denotes confirming
T11100 19382-19383 , denotes ,
T11099 19373-19382 NN denotes apoptosis
T11098 19360-19372 JJ denotes TNF-mediated
T11097 19357-19359 TO denotes to
T11096 19345-19356 JJ denotes susceptible
T11095 19340-19344 RBR denotes more
T11094 19335-19339 RB denotes also
T11553 22111-22112 . denotes .
T11552 22105-22111 NN denotes region
T11551 22100-22104 DT denotes this
T11550 22097-22099 IN denotes in
T11549 22088-22096 NNS denotes elements
T11548 22084-22087 NN denotes DNA
T11547 22073-22083 JJ denotes regulatory
T11546 22063-22072 JJ denotes potential
T11545 22060-22062 IN denotes of
T11544 22051-22059 NN denotes presence
T11543 22047-22050 DT denotes the
T11542 22044-22046 IN denotes by
T11541 22035-22043 RB denotes probably
T11540 22033-22034 , denotes ,
T11539 22032-22033 -RRB- denotes )
T11538 22029-22032 NNP denotes A20
T11537 22026-22028 IN denotes of
T11536 22015-22025 JJ denotes downstream
T11535 22012-22014 NN denotes kb
T11534 22008-22011 CD denotes 150
T11533 22007-22008 FW denotes ~
T11532 22006-22007 -LRB- denotes (
T11531 22001-22005 NN denotes gene
T11530 21993-22000 JJS denotes nearest
T11529 21989-21992 PRP$ denotes its
T11528 21986-21988 IN denotes as
T11527 21982-21985 NNP denotes A20
T11526 21972-21981 VB denotes influence
T11525 21969-21971 TO denotes to
T11524 21961-21968 VBN denotes thought
T11523 21957-21960 VBP denotes are
T11522 21952-21956 PRP denotes they
T11521 21950-21951 , denotes ,
T11520 21946-21950 NN denotes gene
T11519 21944-21945 DT denotes a
T11518 21941-21943 IN denotes in
T11517 21933-21940 VBN denotes located
T11516 21929-21932 RB denotes not
T11515 21925-21928 VBP denotes are
T11514 21916-21924 NNS denotes variants
T11513 21905-21915 VBN denotes identified
T11512 21901-21904 DT denotes the
T11511 21892-21900 IN denotes Although
T11510 21890-21891 . denotes .
T11509 21889-21890 NNP denotes ]
T11508 21887-21889 CD denotes 52
T11507 21886-21887 NNP denotes [
T11506 21883-21885 NNP denotes RA
T11505 21880-21882 TO denotes to
T11504 21865-21879 NN denotes susceptibility
T11503 21861-21864 CC denotes and
T11502 21850-21860 NN denotes chromosome
T11501 21845-21849 JJ denotes 6q23
T11500 21841-21844 DT denotes the
T11499 21838-21840 IN denotes in
T11498 21832-21837 NN denotes locus
T11497 21828-21831 NNP denotes A20
T11496 21824-21827 DT denotes the
T11495 21821-21823 IN denotes in
T11494 21811-21820 NNS denotes mutations
T11493 21803-21810 IN denotes between
T11492 21791-21802 NN denotes association
T11491 21785-21790 JJ denotes clear
T11490 21783-21784 DT denotes a
T11489 21774-21782 VBD denotes revealed
T11488 21769-21773 RB denotes also
T11487 21761-21768 NNS denotes studies
T11486 21749-21760 NN denotes association
T11485 21737-21748 JJ denotes genome-wide
T11484 21729-21736 JJ denotes Several
T11483 21727-21728 . denotes .
T11482 21726-21727 -RRB- denotes )
T11481 21725-21726 NNP denotes ]
T11480 21723-21725 CD denotes 52
T11479 21722-21723 NNP denotes [
T11478 21719-21721 IN denotes in
T11477 21710-21718 VBN denotes reviewed
T11476 21709-21710 -LRB- denotes (
T11475 21697-21708 NNS denotes pathologies
T11474 21686-21696 JJ denotes autoimmune
T11473 21683-21685 IN denotes of
T11472 21671-21682 NN denotes development
T11471 21668-21670 TO denotes to
T11470 21653-21667 NN denotes susceptibility
T11469 21643-21652 VBN denotes increased
T11468 21638-21642 IN denotes with
T11467 21627-21637 VBN denotes associated
T11466 21622-21626 VBN denotes been
T11465 21617-21621 VBP denotes have
T11464 21611-21616 NN denotes locus
T11463 21607-21610 NNP denotes A20
T11462 21601-21606 JJ denotes human
T11461 21597-21600 DT denotes the
T11460 21594-21596 IN denotes in
T11459 21589-21593 NNS denotes SNPs
T11458 21581-21588 JJ denotes several
T11457 21579-21580 , denotes ,
T11456 21568-21579 RB denotes Importantly
T11455 21566-21567 . denotes .
T11454 21561-21566 NNS denotes cells
T11453 21559-21560 NN denotes T
T11452 21556-21558 CC denotes or
T11451 21550-21555 NNS denotes cells
T11450 21548-21549 NNP denotes B
T11449 21546-21547 , denotes ,
T11448 21541-21546 NNS denotes cells
T11447 21531-21540 JJ denotes dendritic
T11446 21529-21530 , denotes ,
T11445 21518-21529 NNS denotes macrophages
T11444 21516-21517 , denotes ,
T11443 21505-21516 NNS denotes fibroblasts
T11442 21496-21504 JJ denotes synovial
T11441 21493-21495 IN denotes as
T11440 21488-21492 JJ denotes such
T11439 21482-21487 NNS denotes types
T11438 21477-21481 NN denotes cell
T11437 21468-21476 JJ denotes specific
T11436 21465-21467 IN denotes in
T11435 21461-21464 CD denotes A20
T11434 21456-21460 VBP denotes lack
T11433 21451-21455 WDT denotes that
T11432 21446-21450 NNS denotes mice
T11431 21437-21445 NN denotes knockout
T11430 21425-21436 JJ denotes conditional
T11429 21422-21424 IN denotes of
T11428 21407-21421 NN denotes susceptibility
T11427 21403-21406 DT denotes the
T11426 21396-21402 JJ denotes future
T11425 21393-21395 IN denotes in
T11424 21385-21392 VB denotes analyse
T11423 21382-21384 TO denotes to
T11422 21370-21381 JJ denotes interesting
T11421 21367-21369 VB denotes be
T11420 21362-21366 MD denotes will
T11419 21359-21361 PRP denotes It
T11418 21357-21358 . denotes .
T11093 19331-19334 VBP denotes are
T11092 19325-19330 NNS denotes cells
T11091 19311-19324 JJ denotes A20-deficient
T11090 19309-19310 . denotes .
T11089 19308-19309 NNP denotes ]
T11088 19306-19308 CD denotes 46
T11087 19305-19306 NNP denotes [
T11086 19296-19304 NN denotes molecule
T11085 19291-19295 DT denotes this
T11084 19288-19290 IN denotes of
T11083 19279-19287 NN denotes function
T11082 19261-19278 JJ denotes anti-inflammatory
T11081 19254-19260 JJ denotes potent
T11080 19250-19253 DT denotes the
T11079 19237-19249 VBG denotes illustrating
T11078 19235-19236 , denotes ,
T11077 19230-19235 NN denotes birth
T11076 19227-19229 IN denotes of
T11075 19221-19226 NNS denotes weeks
T11074 19219-19220 CD denotes 2
T11073 19212-19218 IN denotes within
T11072 19208-19211 VB denotes die
T11071 19204-19207 CC denotes and
T11070 19195-19203 NN denotes cachexia
T11069 19191-19194 CC denotes and
T11068 19178-19190 NN denotes inflammation
T11067 19167-19177 JJ denotes multiorgan
T11066 19159-19166 VBP denotes develop
T11065 19145-19158 RB denotes spontaneously
T11064 19140-19144 NNS denotes mice
T11063 19126-19139 JJ denotes A20-deficient
T11062 19124-19125 . denotes .
T11061 19117-19124 JJ denotes elusive
T11060 19111-19116 RB denotes still
T11059 19107-19110 VBP denotes are
T11058 19105-19106 , denotes ,
T11057 19098-19105 RB denotes however
T11056 19096-19097 , denotes ,
T11055 19086-19096 NN denotes signalling
T11054 19076-19085 JJ denotes apoptotic
T11053 19066-19075 VBZ denotes regulates
T11052 19062-19065 NNP denotes A20
T11051 19056-19061 WDT denotes which
T11050 19053-19055 IN denotes by
T11049 19042-19052 NNS denotes mechanisms
T11048 19038-19041 DT denotes The
T11047 19036-19037 . denotes .
T11046 19031-19036 NNS denotes types
T11045 19026-19030 NN denotes cell
T11044 19021-19025 DT denotes some
T11043 19018-19020 IN denotes in
T11042 19012-19017 JJS denotes least
T11041 19009-19011 IN denotes at
T11040 19007-19008 , denotes ,
T11039 18998-19007 NN denotes apoptosis
T11038 18995-18997 IN denotes of
T11037 18985-18994 NN denotes inhibitor
T11036 18978-18984 JJ denotes strong
T11035 18976-18977 DT denotes a
T11034 18971-18975 RB denotes also
T11033 18968-18970 VBZ denotes is
T11032 18964-18967 NNP denotes A20
T11031 18962-18963 , denotes ,
T11030 18952-18962 NN denotes activation
T11029 18946-18951 JJ denotes NF-κB
T11028 18934-18945 VBG denotes suppressing
T11027 18931-18933 IN denotes in
T11026 18926-18930 NN denotes role
T11025 18922-18925 PRP$ denotes its
T11024 18919-18921 TO denotes to
T11023 18914-18918 JJ denotes Next
T11022 18912-18913 . denotes .
T11021 18911-18912 NNP denotes ]
T11020 18906-18911 CD denotes 43-46
T11019 18905-18906 NNP denotes [
T11018 18903-18904 CD denotes 1
T11017 18895-18902 NN denotes protein
T11016 18882-18894 JJ denotes Tax1-binding
T11015 18878-18881 CC denotes and
T11014 18876-18877 CD denotes 1
T11013 18874-18875 -RRB- denotes )
T11012 18870-18874 NNP denotes ABIN
T11011 18869-18870 -LRB- denotes (
T11010 18863-18868 NNP denotes NF-κB
T11009 18860-18862 IN denotes of
T11008 18850-18859 NN denotes inhibitor
T11007 18838-18849 JJ denotes A20-binding
T11006 18828-18837 VBG denotes including
T11005 18826-18827 , denotes ,
T11004 18818-18826 NNS denotes proteins
T11003 18810-18817 NN denotes adaptor
T11002 18792-18809 JJ denotes ubiquitin-binding
T11001 18783-18791 JJ denotes specific
T11000 18774-18782 VBZ denotes requires
T10999 18766-18773 NNS denotes targets
T10998 18762-18765 PRP$ denotes its
T10997 18757-18761 IN denotes with
T10996 18753-18756 CD denotes A20
T10995 18750-18752 IN denotes of
T10994 18738-18749 NN denotes association
T10993 18734-18737 DT denotes The
T10992 18732-18733 . denotes .
T10991 18731-18732 NNP denotes ]
T10990 18729-18731 CD denotes 42
T10989 18728-18729 NNP denotes [
T10988 18717-18727 JJ denotes signalling
T10987 18711-18716 JJ denotes NF-κB
T10986 18698-18710 VB denotes downregulate
T10985 18695-18697 TO denotes to
T10984 18691-18694 CD denotes A20
T10983 18688-18690 IN denotes by
T10982 18683-18687 VBN denotes used
T10981 18673-18682 NN denotes mechanism
T10980 18663-18672 JJ denotes important
T10979 18655-18662 DT denotes another
T10978 18652-18654 IN denotes as
T10864 17963-17968 VBN denotes known
T10863 17958-17962 RB denotes also
T10862 17957-17958 -LRB- denotes (
T10861 17953-17956 NNP denotes A20
T10860 17945-17952 NN denotes protein
T10859 17941-17944 CD denotes A20
T11201 20033-20035 IN denotes of
T11200 20017-20032 NN denotes pathophysiology
T11199 20013-20016 DT denotes the
T11198 20010-20012 IN denotes in
T11197 20004-20009 NNS denotes roles
T11196 19994-20003 JJ denotes important
T11195 19989-19993 VBP denotes play
T11194 19984-19988 WDT denotes that
T10977 18642-18651 VBN denotes described
T10976 18637-18641 VBD denotes were
T10975 18635-18636 -RRB- denotes )
T10974 18628-18635 NNP denotes cIAP1/2
T10973 18624-18627 CC denotes and
T10972 18618-18623 CD denotes TRAF2
T10971 18616-18617 , denotes ,
T10970 18611-18616 CD denotes TRAF6
T10969 18610-18611 -LRB- denotes (
T10968 18602-18609 NNS denotes ligases
T10967 18592-18601 NN denotes ubiquitin
T10966 18589-18591 CD denotes E3
T10965 18585-18588 CC denotes and
T10964 18583-18584 -RRB- denotes )
T10963 18577-18583 JJ denotes Ubc5hc
T10962 18573-18576 CC denotes and
T10961 18567-18572 JJ denotes Ubc13
T10960 18566-18567 -LRB- denotes (
T10959 18558-18565 NNS denotes enzymes
T10958 18546-18557 VBG denotes conjugating
T10957 18536-18545 NN denotes ubiquitin
T10956 18533-18535 CD denotes E2
T10955 18525-18532 IN denotes between
T10954 18512-18524 NNS denotes interactions
T10953 18509-18511 IN denotes of
T10952 18498-18508 NN denotes disruption
T10951 18494-18497 DT denotes the
T10950 18492-18493 , denotes ,
T10949 18484-18492 RB denotes Recently
T10948 18482-18483 . denotes .
T10947 18481-18482 -RRB- denotes )
T10946 18480-18481 CD denotes 1
T10945 18473-18479 NNP denotes Figure
T10944 18472-18473 -LRB- denotes (
T10943 18470-18471 NNP denotes ]
T10942 18465-18470 CD denotes 38-41
T10941 18464-18465 NNP denotes [
T10940 18451-18463 NNS denotes interactions
T10939 18435-18450 NN denotes protein-protein
T10938 18426-18434 JJ denotes specific
T10937 18417-18425 VBZ denotes disrupts
T10936 18411-18416 WDT denotes which
T10935 18409-18410 , denotes ,
T10934 18404-18409 NNP denotes MALT1
T10933 18400-18403 CC denotes and
T10932 18394-18399 NNP denotes TRAF6
T10931 18392-18393 , denotes ,
T10930 18388-18392 NNP denotes RIP2
T10929 18386-18387 , denotes ,
T10928 18382-18386 NNP denotes RIP1
T10927 18379-18381 IN denotes as
T10926 18374-18378 JJ denotes such
T10925 18372-18373 , denotes ,
T10924 18363-18372 NNS denotes molecules
T10923 18352-18362 VBG denotes signalling
T10922 18346-18351 NN denotes NF-κB
T10921 18337-18345 JJ denotes specific
T10920 18320-18336 VBG denotes deubiquitinating
T10919 18317-18319 IN denotes by
T10918 18308-18316 NN denotes function
T10917 18302-18307 JJ denotes NF-κB
T10916 18294-18301 VB denotes inhibit
T10915 18291-18293 TO denotes to
T10914 18282-18290 VBN denotes believed
T10913 18279-18281 VBZ denotes is
T10912 18275-18278 CD denotes A20
T10911 18273-18274 . denotes .
T10910 18272-18273 -RRB- denotes )
T10909 18271-18272 NNP denotes ]
T10908 18269-18271 CD denotes 37
T10907 18268-18269 NNP denotes [
T10906 18265-18267 IN denotes in
T10905 18256-18264 VBN denotes reviewed
T10904 18255-18256 -LRB- denotes (
T10903 18246-18254 NN denotes receptor
T10902 18244-18245 CD denotes 2
T10901 18226-18243 NN denotes domain-containing
T10900 18210-18225 NN denotes oligomerisation
T10899 18191-18209 JJ denotes nucleotide-binding
T10898 18187-18190 DT denotes the
T10897 18183-18186 CC denotes and
T10896 18178-18182 NNS denotes TLRs
T10895 18175-18177 IN denotes of
T10894 18164-18174 VBG denotes triggering
T10893 18160-18163 DT denotes the
T10892 18156-18159 CC denotes and
T10891 18154-18155 , denotes ,
T10890 18146-18154 NNS denotes antigens
T10889 18142-18145 CC denotes and
T10888 18137-18141 NNP denotes IL-1
T10887 18135-18136 , denotes ,
T10886 18132-18135 NNP denotes TNF
T10885 18122-18131 VBG denotes including
T10884 18120-18121 , denotes ,
T10883 18113-18120 NNS denotes stimuli
T10882 18095-18112 JJ denotes immune-activating
T10881 18085-18094 JJ denotes different
T10880 18082-18084 TO denotes to
T10879 18073-18081 NN denotes response
T10878 18070-18072 IN denotes in
T10877 18059-18069 NN denotes expression
T10876 18054-18058 NN denotes gene
T10875 18038-18053 JJ denotes NF-κB-dependent
T10874 18028-18037 VBZ denotes regulates
T10873 18017-18027 RB denotes negatively
T10872 18012-18016 WDT denotes that
T10871 18004-18011 NN denotes protein
T10870 17986-18003 JJ denotes ubiquitin-editing
T10869 17984-17985 DT denotes a
T10868 17981-17983 VBZ denotes is
T10867 17979-17980 -RRB- denotes )
T10866 17972-17979 CD denotes TNFAIP3
T10865 17969-17971 IN denotes as
T9023 17363-17372 VBD denotes increased
T9022 17358-17362 NN denotes show
T9021 17353-17357 NNP denotes IKK1
T9020 17344-17352 JJ denotes inactive
T9019 17333-17343 VBG denotes expressing
T9018 17328-17332 NNS denotes mice
T9017 17320-17327 VB denotes knockin
T9016 17317-17319 CC denotes or
T9015 17312-17316 NNS denotes mice
T9014 17297-17311 JJ denotes IKK1-deficient
T9013 17292-17296 IN denotes from
T9012 17280-17291 NNS denotes Macrophages
T9011 17278-17279 . denotes .
T9010 17270-17278 NNS denotes pathways
T9009 17264-17269 NN denotes NF-κB
T9008 17251-17263 JJ denotes noncanonical
T9007 17247-17250 CC denotes and
T9006 17237-17246 JJ denotes canonical
T9005 17232-17236 DT denotes both
T9004 17229-17231 IN denotes of
T9003 17218-17228 NN denotes regulation
T9002 17209-17217 JJ denotes negative
T9001 17205-17208 DT denotes the
T9000 17202-17204 IN denotes in
T8999 17197-17201 NN denotes role
T8998 17187-17196 JJ denotes prominent
T8997 17185-17186 DT denotes a
T8996 17179-17184 VBZ denotes plays
T8995 17174-17178 RB denotes also
T8994 17167-17173 NN denotes kinase
T8993 17162-17166 DT denotes this
T8992 17157-17161 IN denotes that
T8991 17147-17156 VBN denotes mentioned
T8990 17144-17146 VB denotes be
T8989 17137-17143 MD denotes should
T8988 17134-17136 PRP denotes it
T8987 17132-17133 , denotes ,
T8986 17125-17132 NN denotes pathway
T8985 17119-17124 NN denotes NF-κB
T8984 17105-17118 JJ denotes non-canonical
T8983 17101-17104 DT denotes the
T8982 17098-17100 IN denotes of
T8981 17088-17097 NN denotes component
T8980 17079-17087 JJ denotes critical
T8979 17077-17078 DT denotes a
T8978 17074-17076 VBZ denotes is
T8977 17069-17073 NNP denotes IKK1
T8976 17050-17068 JJ denotes reported. Although
T8975 17045-17049 VBN denotes been
T8974 17041-17044 RB denotes yet
T8973 17037-17040 RB denotes not
T8972 17033-17036 VBZ denotes has
T8971 17023-17032 NN denotes pathology
T8970 17020-17022 NNP denotes RA
T8969 17015-17019 IN denotes with
T8968 17010-17014 NN denotes link
T8967 17008-17009 DT denotes a
T8966 17002-17007 IN denotes since
T8965 17000-17001 , denotes ,
T8964 16996-17000 RB denotes here
T8963 16986-16995 VBN denotes discussed
T8962 16982-16985 RB denotes not
T8961 16978-16981 VBP denotes are
T8960 16969-16977 NNS denotes proteins
T8959 16963-16968 DT denotes These
T8958 16961-16962 . denotes .
T8957 16960-16961 -RRB- denotes )
T8956 16959-16960 NNP denotes ]
T8955 16957-16959 CD denotes 33
T8954 16956-16957 NNP denotes [
T8953 16953-16955 IN denotes in
T8952 16944-16952 VBN denotes reviewed
T8951 16943-16944 -LRB- denotes (
T8950 16933-16942 VBN denotes described
T8949 16928-16932 VBN denotes been
T8948 16923-16927 VBP denotes have
T8947 16921-16922 , denotes ,
T8946 16915-16921 NNP denotes TOLLIP
T8945 16911-16914 CC denotes and
T8944 16909-16910 , denotes ,
T8943 16903-16909 NNP denotes IRAK-M
T8942 16901-16902 , denotes ,
T8941 16895-16901 NNS denotes MyD88s
T8940 16892-16894 IN denotes as
T8939 16887-16891 JJ denotes such
T8938 16885-16886 , denotes ,
T8937 16876-16885 NNS denotes responses
T8936 16863-16875 JJ denotes inflammatory
T8935 16847-16862 JJ denotes NF-κB-dependent
T8934 16844-16846 IN denotes of
T8933 16833-16843 NN denotes regulation
T8932 16824-16832 JJ denotes negative
T8931 16820-16823 DT denotes the
T8930 16817-16819 IN denotes in
T8929 16808-16816 VBN denotes involved
T8928 16799-16807 NNS denotes proteins
T8927 16793-16798 JJ denotes other
T8926 16785-16792 JJ denotes Several
T8925 16783-16784 . denotes .
T8924 16781-16783 NNP denotes RA
T8923 16778-16780 IN denotes of
T8922 16762-16777 NN denotes immunopathology
T8921 16758-16761 DT denotes the
T8920 16755-16757 IN denotes in
T8919 16747-16754 NNS denotes factors
T8918 16736-16746 NN denotes inhibitory
T8917 16730-16735 JJ denotes NF-κB
T8916 16724-16729 DT denotes these
T8915 16721-16723 IN denotes of
T8914 16716-16720 NN denotes role
T8913 16706-16715 JJ denotes potential
T8912 16702-16705 DT denotes the
T8911 16694-16701 VBP denotes discuss
T8910 16691-16693 PRP denotes we
T8909 16689-16690 , denotes ,
T8908 16681-16689 NN denotes addition
T8907 16678-16680 IN denotes In
T8906 16676-16677 . denotes .
T8905 16672-16676 NN denotes loop
T8904 16663-16671 NN denotes feedback
T8903 16654-16662 JJ denotes negative
T8902 16652-16653 DT denotes a
T8901 16649-16651 IN denotes in
T8900 16642-16648 VBG denotes acting
T8899 16637-16641 RB denotes thus
T8898 16633-16636 CC denotes and
T8897 16626-16632 PRP denotes itself
T8896 16620-16625 JJ denotes NF-κB
T8895 16617-16619 IN denotes of
T8894 16609-16616 NN denotes control
T8893 16605-16608 DT denotes the
T8892 16599-16604 IN denotes under
T8891 16594-16598 PRP denotes them
T8890 16591-16593 IN denotes of
T8889 16586-16590 DT denotes some
T8888 16584-16585 , denotes ,
T8887 16576-16584 NN denotes response
T8886 16570-16575 NNP denotes NF-κB
T8885 16566-16569 DT denotes the
T8884 16563-16565 IN denotes of
T8883 16551-16562 NN denotes termination
T8882 16548-16550 CC denotes or
T8881 16538-16547 NN denotes dampening
T8880 16534-16537 DT denotes the
T8879 16531-16533 IN denotes in
T8878 16522-16530 VBN denotes involved
T8877 16518-16521 VBP denotes are
T8876 16513-16517 WDT denotes that
T8875 16504-16512 NNS denotes proteins
T8874 16501-16503 IN denotes of
T8873 16494-16500 NN denotes number
T8872 16492-16493 DT denotes a
T8871 16489-16491 IN denotes of
T8870 16480-16488 NN denotes overview
T8869 16477-16479 DT denotes an
T8868 16472-16476 VBP denotes give
T8867 16469-16471 PRP denotes we
T8866 16463-16468 IN denotes Below
T8865 16461-16462 . denotes .
T8864 16460-16461 NNP denotes ]
T8863 16458-16460 CD denotes 32
T8862 16457-16458 NNP denotes [
T8861 16446-16456 JJ denotes signalling
T8860 16440-16445 JJ denotes NF-κB
T8859 16427-16439 VBP denotes downregulate
T8858 16422-16426 WDT denotes that
T8857 16413-16421 NNS denotes proteins
T8856 16402-16412 JJ denotes inhibitory
T8855 16399-16401 IN denotes of
T8854 16388-16398 NN denotes expression
T8853 16384-16387 DT denotes the
T8852 16374-16383 VBG denotes including
T8851 16372-16373 , denotes ,
T8850 16362-16372 NNS denotes mechanisms
T8849 16352-16361 JJ denotes different
T8848 16345-16351 VBP denotes employ
T8847 16339-16344 NNS denotes cells
T8846 16337-16338 , denotes ,
T8845 16333-16337 DT denotes this
T8844 16325-16332 VB denotes achieve
T8843 16322-16324 TO denotes To
T8842 16320-16321 . denotes .
T8841 16307-16320 NN denotes tumorigenesis
T8840 16300-16306 CC denotes and/or
T8839 16287-16299 NN denotes inflammation
T8838 16279-16286 JJ denotes chronic
T8837 16276-16278 TO denotes to
T8836 16271-16275 VB denotes lead
T8835 16267-16270 MD denotes may
T8834 16262-16266 WDT denotes that
T8833 16251-16261 NN denotes activation
T8832 16245-16250 NN denotes NF-κB
T8831 16234-16244 JJ denotes persistent
T8830 16226-16233 VB denotes prevent
T8829 16223-16225 TO denotes to
T8828 16213-16222 JJ denotes essential
T8827 16210-16212 VBZ denotes is
T8826 16201-16209 NN denotes response
T8825 16195-16200 JJ denotes NF-κB
T8824 16192-16194 DT denotes an
T8823 16180-16191 VBG denotes terminating
T8822 16178-16179 , denotes ,
T8821 16170-16178 RB denotes Moreover
T8820 16168-16169 . denotes .
T8819 16160-16168 NN denotes response
T8818 16147-16159 JJ denotes inflammatory
T8817 16143-16146 DT denotes the
T8816 16133-16142 VB denotes fine-tune
T8815 16130-16132 TO denotes to
T8814 16118-16129 NN denotes requirement
T8813 16109-16117 JJ denotes absolute
T8812 16106-16108 DT denotes an
T8811 16103-16105 VBZ denotes is
T8810 16095-16102 VBZ denotes induces
T8809 16092-16094 PRP denotes it
T8808 16086-16091 NNS denotes genes
T9112 17938-17939 . denotes .
T9111 17936-17938 NNP denotes RA
T9110 17931-17935 IN denotes like
T9109 17922-17930 NNS denotes diseases
T9108 17909-17921 JJ denotes inflammatory
T9107 17901-17908 JJ denotes chronic
T9106 17897-17900 IN denotes for
T9105 17884-17896 NNS denotes implications
T9104 17875-17883 JJ denotes possible
T9103 17870-17874 IN denotes with
T9102 17861-17869 NNS denotes pathways
T9101 17855-17860 NN denotes NF-κB
T9100 17842-17854 JJ denotes noncanonical
T9099 17838-17841 CC denotes and
T9098 17828-17837 JJ denotes canonical
T9097 17823-17827 DT denotes both
T9096 17811-17822 VBG denotes terminating
T9095 17808-17810 IN denotes in
T9094 17802-17807 NNS denotes roles
T9093 17792-17801 JJ denotes important
T9092 17786-17791 VBZ denotes plays
T9091 17781-17785 NNP denotes IKK1
T9090 17776-17780 WDT denotes that
T9089 17771-17775 NN denotes idea
T9088 17767-17770 DT denotes the
T9087 17756-17766 VBG denotes supporting
T9086 17754-17755 , denotes ,
T9085 17753-17754 NNP denotes ]
T9084 17751-17753 CD denotes 36
T9083 17750-17751 NNP denotes [
T9082 17742-17749 NN denotes pathway
T9081 17736-17741 NN denotes NF-κB
T9080 17723-17735 JJ denotes noncanonical
T9079 17719-17722 DT denotes the
T9078 17716-17718 IN denotes of
T9077 17705-17715 NN denotes regulation
T9076 17696-17704 NN denotes feedback
T9075 17687-17695 JJ denotes negative
T9074 17684-17686 IN denotes in
T9073 17680-17683 NNP denotes NIK
T9072 17665-17679 NNS denotes phosphorylates
T9071 17660-17664 CD denotes IKK1
T9070 17655-17659 IN denotes that
T9069 17642-17654 VBN denotes demonstrated
T9068 17638-17641 VBZ denotes has
T9067 17632-17637 NN denotes study
T9066 17625-17631 JJ denotes recent
T9065 17623-17624 DT denotes a
T9064 17621-17622 , denotes ,
T9063 17608-17621 RB denotes Interestingly
T9062 17606-17607 . denotes .
T9061 17605-17606 NNP denotes ]
T9060 17603-17605 CD denotes 35
T9059 17602-17603 NNP denotes [
T9058 17596-17601 NNP denotes STAT1
T9057 17580-17595 VBG denotes phosphorylating
T9056 17577-17579 IN denotes by
T9055 17566-17576 NN denotes signalling
T9054 17550-17565 JJ denotes proinflammatory
T9053 17537-17549 VB denotes downregulate
T9052 17534-17536 TO denotes to
T9051 17530-17533 CC denotes and
T9050 17524-17529 NN denotes NF-κB
T9049 17516-17523 JJ denotes nuclear
T9048 17508-17515 VB denotes inhibit
T9047 17505-17507 TO denotes to
T9046 17499-17504 VBN denotes shown
T9045 17494-17498 VBN denotes been
T9044 17489-17493 RB denotes also
T9043 17485-17488 VBZ denotes has
T9042 17480-17484 CD denotes IKK1
T9041 17478-17479 . denotes .
T9040 17477-17478 NNP denotes ]
T9039 17475-17477 CD denotes 34
T9038 17474-17475 NNP denotes [
T9037 17462-17473 NN denotes degradation
T9036 17457-17461 NNP denotes IκBα
T9035 17453-17456 CC denotes and
T9034 17442-17452 NN denotes activation
T9033 17437-17441 NNP denotes IKK2
T9032 17428-17436 JJ denotes enhanced
T9031 17425-17427 IN denotes of
T9030 17418-17424 NN denotes result
T9029 17416-17417 DT denotes a
T9028 17413-17415 IN denotes as
T9027 17403-17412 NNS denotes cytokines
T9026 17387-17402 JJ denotes proinflammatory
T9025 17384-17386 IN denotes of
T9024 17373-17383 NN denotes production
T8807 16082-16085 DT denotes the
T8806 16078-16081 CC denotes and
T8805 16070-16077 NN denotes pathway
T8804 16059-16069 VBG denotes signalling
T8803 16053-16058 NN denotes NF-κB
T8802 16049-16052 DT denotes the
T8801 16046-16048 IN denotes of
T8800 16035-16045 NN denotes regulation
T8799 16029-16034 JJ denotes tight
T8798 16027-16028 DT denotes a
T8797 16025-16026 , denotes ,
T8796 16016-16025 NNS denotes processes
T8795 16007-16015 JJ denotes cellular
T8794 16002-16006 JJ denotes many
T8793 15999-16001 TO denotes to
T8792 15991-15998 JJ denotes crucial
T8791 15988-15990 RB denotes so
T8790 15985-15987 VBZ denotes is
T8789 15974-15984 NN denotes activation
T8788 15968-15973 NNP denotes NF-κB
T8787 15962-15967 IN denotes Since
T6864 15913-15914 . denotes .
T6863 15912-15913 NNP denotes ]
T6862 15907-15912 CD denotes 30,31
T6861 15906-15907 NNP denotes [
T6860 15895-15905 VBG denotes signalling
T6859 15890-15894 NNP denotes CD40
T6858 15887-15889 IN denotes of
T6857 15877-15886 NN denotes regulator
T6856 15868-15876 JJ denotes negative
T6855 15866-15867 DT denotes a
T6854 15863-15865 IN denotes as
T6853 15856-15862 VBZ denotes serves
T6852 15850-15855 CD denotes TRAF3
T6851 15846-15849 CC denotes and
T6850 15844-15845 , denotes ,
T6849 15839-15844 NNP denotes NF-κB
T6848 15836-15838 IN denotes of
T6847 15825-15835 NN denotes activation
T6846 15821-15824 IN denotes for
T6845 15812-15820 VBN denotes required
T6844 15809-15811 VBZ denotes is
T6843 15803-15808 CD denotes TRAF2
T6842 15797-15802 IN denotes while
T6841 15795-15796 , denotes ,
T6840 15785-15795 NN denotes production
T6839 15780-15784 NN denotes IL-6
T6838 15776-15779 CC denotes and
T6837 15765-15775 NN denotes activation
T6836 15761-15764 NNP denotes JNK
T6835 15747-15760 JJ denotes CD40-mediated
T6834 15743-15746 IN denotes for
T6833 15734-15742 VBN denotes required
T6832 15731-15733 VBZ denotes is
T6831 15725-15730 NNP denotes TRAF6
T6830 15719-15724 NNS denotes cells
T6829 15717-15718 NNP denotes B
T6828 15714-15716 IN denotes in
T6827 15712-15713 , denotes ,
T6826 15705-15712 NN denotes example
T6825 15701-15704 IN denotes For
T6824 15699-15700 . denotes .
T6823 15690-15699 NNS denotes functions
T6822 15676-15689 JJ denotes CD40-mediated
T6821 15667-15675 JJ denotes distinct
T6820 15663-15666 CC denotes and
T6819 15651-15662 VBG denotes overlapping
T6818 15646-15650 IN denotes with
T6817 15635-15645 VBN denotes associated
T6816 15631-15634 VBP denotes are
T6815 15621-15630 NNS denotes molecules
T6814 15616-15620 NNP denotes TRAF
T6813 15607-15615 JJ denotes Specific
T6812 15605-15606 . denotes .
T6811 15600-15605 IN denotes above
T6810 15590-15599 VBN denotes described
T6809 15587-15589 IN denotes as
T6808 15579-15586 NN denotes pathway
T6807 15566-15578 JJ denotes noncanonical
T6806 15562-15565 DT denotes the
T6805 15559-15561 IN denotes of
T6804 15548-15558 NN denotes activation
T6803 15544-15547 DT denotes the
T6802 15541-15543 IN denotes in
T6801 15536-15540 NN denotes step
T6800 15526-15535 JJ denotes important
T6799 15523-15525 DT denotes an
T6798 15512-15522 VBZ denotes represents
T6797 15506-15511 WDT denotes which
T6796 15504-15505 , denotes ,
T6795 15499-15504 CD denotes TRAF3
T6794 15495-15498 CC denotes and
T6793 15489-15494 CD denotes TRAF2
T6792 15484-15488 DT denotes both
T6791 15481-15483 IN denotes of
T6790 15469-15480 NN denotes proteolysis
T6789 15465-15468 DT denotes the
T6788 15462-15464 TO denotes to
T6787 15456-15461 VBZ denotes leads
T6786 15451-15455 DT denotes this
T6785 15447-15450 CC denotes and
T6784 15445-15446 , denotes ,
T6783 15440-15445 NNP denotes TRAF6
T6782 15436-15439 CC denotes and
T6781 15434-15435 , denotes ,
T6780 15429-15434 CD denotes TRAF5
T6779 15427-15428 , denotes ,
T6778 15422-15427 CD denotes TRAF3
T6777 15420-15421 , denotes ,
T6776 15415-15420 CD denotes TRAF2
T6775 15413-15414 , denotes ,
T6774 15408-15413 CD denotes TRAF1
T6773 15398-15407 VBG denotes including
T6772 15396-15397 , denotes ,
T6771 15389-15396 NNS denotes members
T6770 15384-15388 NNP denotes TRAF
T6769 15376-15383 JJ denotes several
T6768 15371-15375 IN denotes with
T6767 15362-15370 NN denotes interact
T6766 15357-15361 NNP denotes RANK
T6765 15353-15356 CC denotes and
T6764 15348-15352 NNP denotes CD40
T6763 15346-15347 , denotes ,
T6762 15340-15346 NN denotes ligand
T6761 15334-15339 PRP$ denotes their
T6760 15331-15333 IN denotes of
T6759 15323-15330 JJ denotes binding
T6758 15318-15322 IN denotes Upon
T6757 15316-15317 . denotes .
T6756 15308-15316 NNS denotes pathways
T6755 15297-15307 VBG denotes signalling
T6754 15291-15296 NN denotes NF-κB
T6753 15278-15290 JJ denotes noncanonical
T6752 15274-15277 CC denotes and
T6751 15264-15273 JJ denotes canonical
T6750 15259-15263 DT denotes both
T6749 15256-15258 IN denotes of
T6748 15245-15255 NN denotes activation
T6747 15241-15244 DT denotes the
T6746 15233-15240 VB denotes mediate
T6745 15228-15232 VB denotes RANK
T6744 15224-15227 CC denotes and
T6743 15215-15223 NN denotes receptor
T6742 15213-15214 NN denotes β
T6741 15201-15212 NN denotes lymphotoxin
T6740 15199-15200 , denotes ,
T6739 15195-15199 NNP denotes CD40
T6738 15190-15194 IN denotes that
T6737 15180-15189 VBN denotes mentioned
T6736 15177-15179 VB denotes be
T6735 15170-15176 MD denotes should
T6734 15167-15169 PRP denotes It
T6733 13837-13838 . denotes .
T6732 13836-13837 -RRB- denotes )
T6731 13835-13836 CD denotes 2
T6730 13828-13834 NNP denotes Figure
T6729 13827-13828 -LRB- denotes (
T6728 13825-13826 NNP denotes ]
T6727 13820-13825 CD denotes 28,29
T6726 13819-13820 NNP denotes [
T6725 13803-13818 NN denotes phosphorylation
T6724 13798-13802 CD denotes IKK1
T6723 13794-13797 CC denotes and
T6722 13781-13793 NN denotes accumulation
T6721 13777-13780 NNP denotes NIK
T6720 13774-13776 IN denotes in
T6719 13764-13773 VBG denotes resulting
T6718 13762-13763 , denotes ,
T6717 13751-13762 NN denotes degradation
T6716 13738-13750 JJ denotes constitutive
T6715 13734-13737 PRP$ denotes its
T6714 13729-13733 IN denotes from
T6713 13725-13728 NNP denotes NIK
T6712 13715-13724 VBG denotes releasing
T6711 13712-13714 TO denotes to
T6710 13700-13711 VBZ denotes contributes
T6709 13695-13699 DT denotes this
T6708 13691-13694 PDT denotes All
T6707 13689-13690 . denotes .
T6706 13678-13689 NN denotes degradation
T6705 13672-13677 CD denotes TRAF3
T6704 13661-13671 JJ denotes subsequent
T6703 13657-13660 IN denotes for
T6702 13647-13656 JJ denotes essential
T6701 13643-13646 VBP denotes are
T6700 13637-13642 WDT denotes which
T6699 13635-13636 , denotes ,
T6698 13628-13635 NNP denotes cIAP1/2
T6691 13596-13597 , denotes ,
T6690 13588-13596 NN denotes receptor
T6689 13584-13587 DT denotes the
T6688 13581-13583 TO denotes to
T6687 13578-13580 PRP denotes it
T6686 13567-13577 VBG denotes recruiting
T6685 13564-13566 IN denotes by
T6684 13556-13563 JJ denotes complex
T6683 13551-13555 DT denotes this
T6682 13546-13550 IN denotes from
T6681 13540-13545 CD denotes TRAF3
T6680 13533-13539 VB denotes remove
T6679 13530-13532 TO denotes to
T6678 13525-13529 RB denotes only
T6677 13521-13524 RB denotes not
T6676 13515-13520 VBN denotes shown
T6675 13510-13514 VBN denotes been
T6674 13506-13509 VBZ denotes has
T6673 13497-13505 NN denotes ligation
T6672 13488-13496 NN denotes Receptor
T6671 13486-13487 . denotes .
T6670 13476-13486 JJ denotes proteasome
T6669 13472-13475 DT denotes the
T6668 13469-13471 IN denotes by
T6667 13457-13468 NN denotes degradation
T6666 13446-13456 JJ denotes continuous
T6665 13442-13445 PRP$ denotes its
T6664 13439-13441 TO denotes to
T6663 13431-13438 VBG denotes leading
T6662 13429-13430 , denotes ,
T6661 13426-13429 NNP denotes NIK
T6660 13404-13425 VBZ denotes K48-polyubiquitinates
T6659 13398-13403 WDT denotes which
T6658 13396-13397 , denotes ,
T6657 13389-13396 NNP denotes cIAP1/2
T6656 13385-13388 CC denotes and
T6655 13383-13384 , denotes ,
T6654 13378-13383 CD denotes TRAF3
T6653 13376-13377 , denotes ,
T6652 13371-13376 CD denotes TRAF2
T6651 13366-13370 IN denotes with
T6650 13358-13365 NN denotes complex
T6649 13346-13357 JJ denotes cytoplasmic
T6648 13344-13345 DT denotes a
T6647 13341-13343 IN denotes in
T6646 13334-13340 VBZ denotes occurs
T6645 13330-13333 NNP denotes NIK
T6644 13328-13329 , denotes ,
T6643 13323-13328 NNS denotes cells
T6642 13310-13322 JJ denotes unstimulated
T6641 13307-13309 IN denotes In
T6640 13305-13306 . denotes .
T6639 13300-13305 NNS denotes types
T6638 13295-13299 NN denotes cell
T6637 13290-13294 JJS denotes most
T6636 13287-13289 IN denotes in
T6635 13280-13286 NNS denotes levels
T6634 13276-13279 JJ denotes low
T6633 13266-13275 RB denotes extremely
T6632 13263-13265 IN denotes at
T6631 13255-13262 JJ denotes present
T6630 13252-13254 VBZ denotes is
T6629 13248-13251 CC denotes and
T6628 13242-13247 NN denotes level
T6627 13223-13241 JJ denotes post-translational
T6626 13219-13222 DT denotes the
T6625 13216-13218 IN denotes at
T6624 13206-13215 VBN denotes regulated
T6623 13192-13205 RB denotes predominantly
T6622 13189-13191 VBZ denotes is
T6621 13185-13188 NNP denotes NIK
T6620 13183-13184 . denotes .
T6619 13182-13183 -RRB- denotes )
T6618 13179-13182 NNP denotes NIK
T6617 13178-13179 -LRB- denotes (
T6616 13171-13177 NN denotes kinase
T6615 13162-13170 VBG denotes inducing
T6614 13156-13161 JJ denotes NF-κB
T6613 13153-13155 IN denotes by
T6612 13137-13152 NN denotes phosphorylation
T6611 13132-13136 IN denotes upon
T6610 13122-13131 VBN denotes activated
T6609 13119-13121 VBZ denotes is
T6608 13113-13118 WDT denotes which
T6607 13111-13112 , denotes ,
T6606 13107-13111 NNP denotes IKK1
T6605 13104-13106 IN denotes on
T6604 13094-13103 JJ denotes dependent
T6603 13085-13093 RB denotes strictly
T6602 13082-13084 VBZ denotes is
T6601 13074-13081 NN denotes pathway
T6600 13068-13073 NN denotes NF-κB
T6599 13055-13067 JJ denotes noncanonical
T6598 13051-13054 DT denotes The
T6597 13049-13050 NNP denotes ]
T6596 13047-13049 CD denotes 27
T6595 13046-13047 NNP denotes [
T6594 13027-13045 NN denotes osteoclastogenesis
T6593 13023-13026 CC denotes and
T6592 13021-13022 , denotes ,
T6591 13010-13021 NN denotes development
T6590 13004-13009 NN denotes organ
T6589 12995-13003 JJ denotes lymphoid
T6588 12985-12994 JJ denotes secondary
T6587 12983-12984 , denotes ,
T6586 12972-12983 NN denotes development
T6585 12965-12971 JJ denotes B-cell
T6584 12957-12964 VBP denotes control
T6583 12952-12956 WDT denotes that
T6582 12946-12951 NNS denotes genes
T6581 12939-12945 NN denotes target
T6580 12936-12938 IN denotes of
T6579 12932-12935 NN denotes set
T6578 12923-12931 JJ denotes distinct
T6577 12921-12922 DT denotes a
T6576 12911-12920 VBZ denotes regulates
T6575 12903-12910 NN denotes subunit
T6574 12897-12902 NNP denotes NF-κB
T6573 12892-12896 NNP denotes RelB
T6572 12888-12891 DT denotes the
T6571 12883-12887 IN denotes with
T6570 12874-12882 RB denotes together
T6569 12868-12873 WDT denotes which
T6568 12866-12867 , denotes ,
T6567 12863-12866 VB denotes p52
T6566 12860-12862 TO denotes to
T6565 12849-12859 JJ denotes proteasome
T6564 12845-12848 DT denotes the
T6563 12842-12844 IN denotes by
T6562 12832-12841 VBN denotes processed
T6561 12829-12831 VBZ denotes is
T6560 12824-12828 NN denotes p100
T6559 12822-12823 , denotes ,
T6558 12815-12822 NN denotes pathway
T6557 12810-12814 DT denotes this
T6556 12807-12809 IN denotes In
T6555 12805-12806 . denotes .
T6554 12804-12805 -RRB- denotes )
T6553 12803-12804 CD denotes 2
T6552 12796-12802 NNP denotes Figure
T6551 12795-12796 -LRB- denotes (
T6550 12790-12794 NNP denotes RANK
T6549 12786-12789 CC denotes and
T6548 12784-12785 , denotes ,
T6547 12780-12784 NNP denotes CD40
T6546 12778-12779 , denotes ,
T6545 12770-12778 NN denotes receptor
T6544 12765-12769 NN denotes BAFF
T6543 12763-12764 , denotes ,
T6542 12755-12763 NN denotes receptor
T6541 12753-12754 NN denotes β
T6540 12741-12752 NN denotes lymphotoxin
T6539 12737-12740 DT denotes the
T6538 12734-12736 IN denotes by
T6537 12724-12733 VBN denotes activated
T6536 12721-12723 VB denotes be
T6535 12717-12720 MD denotes can
T6534 12709-12716 NN denotes pathway
T6533 12703-12708 NN denotes NF-κB
T6532 12690-12702 JJ denotes noncanonical
T6531 12686-12689 DT denotes The
T6530 12684-12685 . denotes .
T6529 12683-12684 -RRB- denotes )
T6528 12682-12683 CD denotes 1
T6527 12675-12681 NN denotes Figure
T6526 12674-12675 -LRB- denotes (
T6525 12666-12673 NN denotes pathway
T6524 12662-12665 NNP denotes TNF
T6523 12658-12661 DT denotes the
T6522 12655-12657 TO denotes to
T6521 12647-12654 JJ denotes similar
T6520 12640-12646 NN denotes manner
T6519 12615-12639 JJ denotes ubiquitination-dependent
T6518 12613-12614 DT denotes a
T6517 12610-12612 IN denotes in
T6516 12606-12609 NNP denotes IKK
T6515 12602-12605 CC denotes and
T6514 12597-12601 CD denotes TAK1
T6513 12588-12596 VBP denotes activate
T6512 12583-12587 RB denotes then
T6511 12574-12582 NNS denotes pathways
T6510 12569-12573 DT denotes Both
T6509 12567-12568 . denotes .
T6508 12556-12567 NN denotes interaction
T6507 12549-12555 JJ denotes direct
T6506 12547-12548 DT denotes a
T6505 12543-12546 IN denotes via
T6504 12541-12542 NNP denotes ]
T6503 12539-12541 CD denotes 26
T6502 12538-12539 NNP denotes [
T6501 12533-12537 NNP denotes RIP1
T6500 12529-12532 CC denotes and
T6499 12527-12528 NNP denotes ]
T6498 12525-12527 CD denotes 25
T6497 12524-12525 NNP denotes [
T6496 12518-12523 CD denotes TRAF6
T6495 12509-12517 VBZ denotes recruits
T6494 12504-12508 RB denotes also
T6493 12499-12503 NNP denotes TRIF
T6492 12497-12498 . denotes .
T6491 12496-12497 NNP denotes ]
T6490 12494-12496 CD denotes 24
T6489 12493-12494 NNP denotes [
T6488 12487-12492 CD denotes TRAF6
T6487 12484-12486 IN denotes of
T6486 12465-12483 NN denotes selfubiquitination
T6485 12461-12464 CC denotes and
T6484 12445-12460 NN denotes oligomerisation
T6483 12442-12444 TO denotes to
T6482 12434-12441 VBG denotes leading
T6481 12432-12433 , denotes ,
T6480 12427-12432 CD denotes TRAF6
T6479 12423-12426 CC denotes and
T6478 12416-12422 NN denotes family
T6477 12414-12415 -RRB- denotes )
T6476 12410-12414 NNP denotes IRAK
T6404 11970-11979 NNS denotes receptors
T6403 11964-11969 JJ denotes other
T6402 11961-11963 TO denotes to
T6401 11955-11960 VBP denotes apply
T6400 11944-11954 NNS denotes principles
T6399 11933-11943 JJ denotes signalling
T6398 11925-11932 JJ denotes Similar
T6397 11923-11924 . denotes .
T6396 11922-11923 NNP denotes ]
T6395 11920-11922 CD denotes 23
T6394 11919-11920 NNP denotes [
T6393 11911-11918 JJ denotes complex
T6392 11906-11910 CD denotes TAK1
T6391 11902-11905 DT denotes the
T6390 11893-11901 VB denotes activate
T6389 11884-11892 RB denotes directly
T6388 11880-11883 MD denotes can
T6387 11873-11879 NNS denotes chains
T6386 11859-11872 NN denotes polyubiquitin
T6385 11848-11858 JJ denotes unanchored
T6384 11843-11847 IN denotes that
T6383 11833-11842 VBN denotes suggested
T6382 11824-11832 RB denotes recently
T6381 11820-11823 VBD denotes was
T6380 11817-11819 PRP denotes it
T6379 11814-11816 IN denotes as
T6378 11812-11813 , denotes ,
T6377 11805-11812 JJ denotes unclear
T6376 11797-11804 VBZ denotes remains
T6375 11790-11796 NNS denotes chains
T6374 11776-11789 NN denotes polyubiquitin
T6373 11759-11775 JJ denotes protein-anchored
T6372 11756-11758 IN denotes of
T6371 11751-11755 NN denotes role
T6370 11745-11750 JJ denotes exact
T6369 11741-11744 DT denotes The
T6368 11739-11740 . denotes .
T6367 11738-11739 NNP denotes ]
T6366 11736-11738 CD denotes 22
T6365 11735-11736 NNP denotes [
T6364 11724-11734 NN denotes complexity
T6363 11716-11723 JJ denotes further
T6362 11711-11715 VBZ denotes adds
T6361 11700-11710 NN denotes signalling
T6360 11694-11699 JJ denotes NF-κB
T6359 11680-11693 JJ denotes TNF-activated
T6358 11676-11679 IN denotes for
T6357 11666-11675 JJ denotes essential
T6356 11663-11665 VBZ denotes is
T6355 11659-11662 CC denotes and
T6354 11652-11658 NNS denotes chains
T6353 11638-11651 NN denotes polyubiquitin
T6352 11631-11637 JJ denotes linear
T6351 11626-11630 IN denotes with
T6350 11621-11625 NNP denotes NEMO
T6349 11612-11620 VBZ denotes modifies
T6348 11607-11611 WDT denotes that
T6347 11599-11606 NN denotes complex
T6346 11592-11598 NN denotes enzyme
T6345 11586-11591 CD denotes E2/E3
T6344 11577-11585 JJ denotes distinct
T6343 11575-11576 DT denotes a
T6342 11572-11574 IN denotes of
T6341 11557-11571 NN denotes identification
T6340 11550-11556 JJ denotes recent
T6339 11546-11549 DT denotes The
T6338 11544-11545 . denotes .
T6337 11532-11544 RB denotes respectively
T6336 11530-11531 , denotes ,
T6335 11524-11530 NNP denotes TAB1/2
T6334 11520-11523 CC denotes and
T6333 11515-11519 NNP denotes NEMO
T6332 11506-11514 NNS denotes proteins
T6331 11488-11505 JJ denotes ubiquitin-binding
T6330 11484-11487 DT denotes the
T6329 11480-11483 IN denotes via
T6328 11472-11479 JJ denotes complex
T6327 11467-11471 CD denotes TAK1
T6326 11463-11466 CC denotes and
T6325 11459-11462 NNP denotes IKK
T6324 11455-11458 DT denotes the
T6323 11447-11454 VB denotes recruit
T6322 11444-11446 TO denotes to
T6321 11435-11443 NN denotes scaffold
T6320 11433-11434 DT denotes a
T6319 11426-11432 VB denotes create
T6318 11423-11425 TO denotes to
T6317 11414-11422 VBN denotes believed
T6316 11410-11413 VBP denotes are
T6315 11405-11409 NNP denotes RIP1
T6314 11402-11404 IN denotes on
T6313 11395-11401 NNS denotes chains
T6312 11381-11394 NN denotes polyubiquitin
T6311 11377-11380 DT denotes The
T6310 11375-11376 . denotes .
T6309 11368-11375 JJ denotes unclear
T6308 11362-11367 RB denotes still
T6307 11359-11361 VBZ denotes is
T6306 11354-11358 DT denotes each
T6305 11351-11353 IN denotes of
T6697 13624-13627 CC denotes and
T6696 13618-13623 CD denotes TRAF2
T6695 13610-13617 VB denotes attract
T6694 13607-13609 TO denotes to
T6693 13602-13606 RB denotes also
T6692 13598-13601 CC denotes but
T6304 11346-11350 NN denotes role
T6303 11337-11345 JJ denotes specific
T6302 11333-11336 DT denotes the
T6301 11329-11332 CC denotes but
T6300 11327-11328 , denotes ,
T6299 11313-11327 NN denotes ubiquitination
T6298 11308-11312 NNP denotes RIP1
T6297 11304-11307 IN denotes for
T6296 11293-11303 NNS denotes candidates
T6295 11288-11292 JJ denotes good
T6294 11284-11287 VBP denotes are
T6293 11276-11283 NNP denotes cIAP1/2
T6292 11272-11275 CC denotes and
T6291 11264-11271 CD denotes TRAF2/5
T6290 11262-11263 . denotes .
T6289 11256-11262 NNS denotes chains
T6288 11242-11255 NN denotes polyubiquitin
T6287 11231-11241 JJ denotes K63-linked
T6286 11228-11230 IN denotes by
T6285 11219-11227 VBN denotes modified
T6284 11211-11218 RB denotes rapidly
T6283 11208-11210 VBZ denotes is
T6282 11203-11207 NNP denotes RIP1
T6281 11197-11202 VBN denotes bound
T6280 11184-11196 JJ denotes TNF-receptor
T6279 11182-11183 , denotes ,
T6278 11171-11182 NN denotes stimulation
T6277 11167-11170 NNP denotes TNF
T6276 11164-11166 IN denotes On
T6275 11162-11163 . denotes .
T6274 11161-11162 -RRB- denotes )
T6273 11160-11161 CD denotes 1
T6272 11153-11159 NNP denotes Figure
T6271 11152-11153 -LRB- denotes (
T6270 11146-11151 NNP denotes cIAP2
T6269 11142-11145 CC denotes and
T6268 11140-11141 CD denotes 1
T6267 11138-11139 -RRB- denotes )
T6266 11134-11138 NNP denotes cIAP
T6265 11133-11134 -LRB- denotes (
T6264 11123-11132 NN denotes apoptosis
T6263 11120-11122 IN denotes of
T6262 11110-11119 NN denotes inhibitor
T6261 11101-11109 JJ denotes cellular
T6260 11093-11100 VBZ denotes ligases
T6259 11083-11092 NN denotes ubiquitin
T6258 11080-11082 CD denotes E3
T6257 11076-11079 DT denotes the
T6256 11071-11075 NN denotes bind
T6255 11066-11070 NN denotes turn
T6254 11063-11065 IN denotes in
T6253 11057-11062 WDT denotes which
T6252 11055-11056 , denotes ,
T6251 11050-11055 CD denotes TRAF5
T6250 11046-11049 CC denotes and
T6249 11044-11045 CD denotes 2
T6248 11042-11043 -RRB- denotes )
T6247 11038-11042 NNP denotes TRAF
T6246 11037-11038 -LRB- denotes (
T6245 11030-11036 NN denotes factor
T6244 11010-11029 JJ denotes receptor-associated
T6243 11006-11009 NNP denotes TNF
T6242 10998-11005 VBZ denotes ligases
T6241 10988-10997 NN denotes ubiquitin
T6240 10985-10987 CD denotes E3
T6239 10981-10984 DT denotes the
T6238 10977-10980 IN denotes for
T6237 10968-10976 NNS denotes proteins
T6236 10960-10967 NN denotes adaptor
T6235 10957-10959 IN denotes as
T6234 10948-10956 VBP denotes function
T6233 10942-10947 WDT denotes which
T6232 10940-10941 , denotes ,
T6231 10939-10940 -RRB- denotes )
T6230 10935-10939 NN denotes RIP1
T6229 10934-10935 -LRB- denotes (
T6228 10932-10933 CD denotes 1
T6227 10924-10931 NN denotes protein
T6226 10912-10923 VBG denotes interacting
T6225 10903-10911 NN denotes receptor
T6224 10900-10902 IN denotes of
T6223 10896-10899 CC denotes and
T6222 10888-10895 NN denotes protein
T6221 10886-10887 -RRB- denotes )
T6220 10881-10886 NNP denotes TRADD
T6219 10880-10881 -LRB- denotes (
T6218 10873-10879 NN denotes domain
T6217 10867-10872 NN denotes death
T6216 10845-10866 JJ denotes receptor-1-associated
T6215 10841-10844 NNP denotes TNF
T6214 10838-10840 IN denotes of
T6213 10826-10837 NN denotes recruitment
T6212 10822-10825 DT denotes the
T6211 10819-10821 IN denotes in
T6210 10811-10818 NNS denotes results
T6209 10799-10810 NN denotes stimulation
T6208 10795-10798 NNP denotes TNF
T6207 10793-10794 . denotes .
T6206 10786-10793 NN denotes pathway
T6205 10782-10785 NNP denotes TNF
T6204 10778-10781 DT denotes the
T6203 10775-10777 VBZ denotes is
T6202 10766-10774 NNS denotes pathways
T6201 10755-10765 VBG denotes signalling
T6200 10749-10754 NNP denotes NF-κB
T6199 10741-10748 VBN denotes studied
T6198 10736-10740 JJS denotes best
T6197 10732-10735 DT denotes the
T6196 10729-10731 IN denotes of
T6195 10725-10728 CD denotes One
T6194 8528-8529 . denotes .
T6193 8527-8528 NNP denotes ]
T6192 8525-8527 CD denotes 21
T6191 8524-8525 NNP denotes [
T6190 8513-8523 NN denotes activation
T6189 8507-8512 NN denotes NF-κB
T5971 7303-7304 -RRB- denotes )
T5970 7297-7303 NN denotes NF-κB1
T5969 7294-7296 IN denotes as
T5968 7288-7293 VBN denotes known
T5967 7283-7287 RB denotes also
T5966 7282-7283 -LRB- denotes (
T5965 7277-7281 NNS denotes p105
T5964 7275-7276 , denotes ,
T5963 7271-7275 NNP denotes IκBε
T5962 7269-7270 , denotes ,
T5961 7265-7269 NNP denotes IκBβ
T5960 7263-7264 , denotes ,
T5959 7259-7263 NNP denotes IκBα
T5958 7258-7259 -LRB- denotes (
T5957 7253-7257 NNS denotes IκBs
T5956 7250-7252 IN denotes of
T5955 7241-7249 NN denotes majority
T5954 7237-7240 DT denotes the
T5953 7229-7236 IN denotes Whereas
T5952 7227-7228 . denotes .
T5951 7226-7227 NNP denotes ]
T5950 7224-7226 CD denotes 19
T5949 7223-7224 NNP denotes [
T5948 7215-7222 JJ denotes binding
T5947 7211-7214 NN denotes DNA
T5946 7207-7210 CC denotes and
T5945 7193-7206 NN denotes translocation
T5944 7185-7192 JJ denotes nuclear
T5943 7179-7184 JJ denotes NF-κB
T5942 7171-7178 VBP denotes prevent
T5941 7165-7170 WDT denotes which
T5940 7163-7164 , denotes ,
T5939 7155-7163 NNS denotes proteins
T5938 7153-7154 -RRB- denotes )
T5937 7150-7153 NNP denotes IκB
T5936 7149-7150 -LRB- denotes (
T5935 7143-7148 NNP denotes NF-κB
T5934 7140-7142 IN denotes of
T5933 7130-7139 NN denotes inhibitor
T5932 7127-7129 IN denotes as
T5931 7124-7126 TO denotes to
T5930 7115-7123 VBD denotes referred
T5929 7106-7114 NNS denotes proteins
T5928 7095-7105 JJ denotes inhibitory
T5927 7092-7094 IN denotes by
T5926 7082-7091 NNS denotes complexes
T5925 7075-7081 NN denotes latent
T5924 7072-7074 IN denotes as
T5923 7062-7071 NN denotes cytoplasm
T5922 7058-7061 DT denotes the
T5921 7055-7057 IN denotes in
T5920 7043-7054 VBN denotes sequestered
T5919 7039-7042 VBP denotes are
T5918 7030-7038 NNS denotes proteins
T5917 7024-7029 NN denotes NF-κB
T6475 12409-12410 -LRB- denotes (
T6474 12402-12408 NN denotes kinase
T6473 12385-12401 JJ denotes IL-1R-associated
T6472 12381-12384 DT denotes the
T6471 12378-12380 IN denotes of
T6470 12370-12377 NNS denotes members
T6469 12361-12369 NNS denotes recruits
T6468 12356-12360 NN denotes turn
T6467 12353-12355 IN denotes in
T6466 12347-12352 CD denotes MyD88
T6465 12345-12346 . denotes .
T6464 12333-12345 RB denotes respectively
T6463 12331-12332 , denotes ,
T6462 12330-12331 -RRB- denotes )
T6461 12326-12330 NNP denotes TRIF
T6460 12325-12326 -LRB- denotes (
T6459 12320-12324 NNP denotes IFNβ
T6458 12303-12319 JJ denotes adaptor-inducing
T6457 12285-12302 JJ denotes domain-containing
T6456 12281-12284 NNP denotes TIR
T6455 12277-12280 CC denotes and
T6454 12275-12276 -RRB- denotes )
T6453 12270-12275 NNP denotes MyD88
T6452 12269-12270 -LRB- denotes (
T6451 12266-12268 CD denotes 88
T6450 12261-12265 NN denotes gene
T6449 12252-12260 NN denotes response
T6448 12244-12251 JJ denotes primary
T6447 12228-12243 NN denotes differentiation
T6446 12220-12227 JJ denotes myeloid
T6445 12212-12219 VB denotes recruit
T6444 12209-12211 TO denotes to
T6443 12201-12208 NNS denotes factors
T6442 12192-12200 VBG denotes bridging
T6441 12189-12191 IN denotes as
T6440 12183-12188 VBP denotes serve
T6439 12174-12182 RB denotes probably
T6438 12169-12173 RBS denotes most
T6437 12163-12168 WDT denotes which
T6436 12161-12162 , denotes ,
T6435 12160-12161 -RRB- denotes )
T6434 12156-12160 NNP denotes TRAM
T6433 12155-12156 -LRB- denotes (
T6432 12146-12154 NN denotes molecule
T6431 12138-12145 NN denotes adaptor
T6430 12125-12137 JJ denotes TRIF-related
T6429 12121-12124 CC denotes and
T6428 12119-12120 -RRB- denotes )
T6427 12116-12119 NNP denotes Mal
T6426 12113-12115 IN denotes as
T6425 12110-12112 TO denotes to
T6424 12101-12109 VBD denotes referred
T6423 12096-12100 RB denotes also
T6422 12095-12096 -LRB- denotes (
T6421 12087-12094 NN denotes protein
T6420 12079-12086 NN denotes adaptor
T6419 12070-12078 NN denotes receptor
T6418 12067-12069 CD denotes -1
T6417 12060-12067 NNP denotes Toll/IL
T6416 12057-12059 IN denotes of
T6415 12045-12056 NN denotes recruitment
T6414 12041-12044 DT denotes the
T6413 12033-12040 VBZ denotes induces
T6412 12014-12032 NN denotes lipopolysaccharide
T6411 12011-12013 IN denotes by
T6410 11999-12010 NN denotes stimulation
T6409 11994-11998 CD denotes TLR4
T6408 11992-11993 , denotes ,
T6407 11985-11992 NN denotes example
T6406 11981-11984 IN denotes For
T6405 11979-11980 . denotes .
T6161 8378-8379 : denotes -
T6160 8373-8377 SYM denotes NEMO
T6159 8372-8373 -LRB- denotes (
T6158 8362-8371 NN denotes modulator
T6157 8352-8361 JJ denotes essential
T6156 8346-8351 NN denotes NF-κB
T6155 8338-8345 NN denotes subunit
T6154 8327-8337 JJ denotes regulatory
T6153 8323-8326 DT denotes the
T6152 8319-8322 CC denotes and
T6151 8317-8318 -RRB- denotes )
T6150 8313-8317 NNP denotes IKKβ
T6149 8309-8312 CC denotes and
T6148 8304-8308 NNP denotes IKKα
T6147 8301-8303 IN denotes as
T6146 8295-8300 VBN denotes known
T6145 8290-8294 RB denotes also
T6144 8289-8290 -LRB- denotes (
T6143 8284-8288 NNP denotes IKK2
T6142 8280-8283 CC denotes and
T6141 8275-8279 NNP denotes IKK1
T6140 8266-8274 NNS denotes subunits
T6139 8256-8265 JJ denotes catalytic
T6138 8252-8255 CD denotes two
T6137 8248-8251 DT denotes the
T6136 8245-8247 IN denotes of
T6135 8235-8244 VBN denotes comprised
T6134 8232-8234 VBZ denotes is
T6133 8224-8231 NN denotes complex
T6132 8220-8223 NNP denotes IKK
T6131 8216-8219 DT denotes The
T6130 8214-8215 . denotes .
T6129 8213-8214 NNP denotes ]
T6128 8211-8213 CD denotes 20
T6127 8210-8211 NNP denotes [
T6126 8199-8209 JJ denotes proteasome
T6125 8195-8198 DT denotes the
T6124 8192-8194 IN denotes by
T6123 8180-8191 NN denotes degradation
T6122 8176-8179 CC denotes and
T6121 8153-8175 NN denotes K48-polyubiquitination
T6120 8149-8152 PRP$ denotes its
T6119 8146-8148 TO denotes to
T6118 8138-8145 VBG denotes leading
T6117 8130-8137 NN denotes protein
T6116 8126-8129 NNP denotes IκB
T6115 8115-8125 JJ denotes inhibitory
T6114 8111-8114 DT denotes the
T6113 8108-8110 IN denotes of
T6112 8092-8107 NN denotes phosphorylation
T6111 8083-8091 VBZ denotes mediates
T6110 8077-8082 WDT denotes which
T6109 8075-8076 , denotes ,
T6108 8068-8075 JJ denotes complex
T6107 8066-8067 -RRB- denotes )
T6106 8063-8066 NNP denotes IKK
T6105 8062-8063 -LRB- denotes (
T6104 8055-8061 NN denotes kinase
T6103 8051-8054 NNP denotes IκB
T6102 8047-8050 DT denotes the
T6101 8044-8046 IN denotes of
T6100 8033-8043 NN denotes activation
T6099 8029-8032 DT denotes the
T6098 8026-8028 IN denotes in
T6097 8017-8025 NN denotes converge
T6096 8006-8016 RB denotes ultimately
T6095 8002-8005 CC denotes but
T6094 8000-8001 , denotes ,
T6093 7992-8000 JJ denotes specific
T6092 7983-7991 NN denotes receptor
T6091 7977-7982 RB denotes often
T6090 7973-7976 VBP denotes are
T6089 7968-7972 WDT denotes that
T6088 7955-7967 NNS denotes interactions
T6087 7939-7954 NN denotes protein-protein
T6086 7930-7938 JJ denotes proximal
T6085 7927-7929 IN denotes of
T6084 7917-7926 NN denotes formation
T6083 7913-7916 DT denotes the
T6082 7904-7912 VBZ denotes requires
T6081 7894-7903 NNS denotes receptors
T6080 7884-7893 JJ denotes different
T6079 7881-7883 IN denotes by
T6078 7871-7880 VBN denotes initiated
T6077 7860-7870 JJ denotes signalling
T6076 7854-7859 JJ denotes NF-κB
T6075 7852-7853 . denotes .
T6074 7845-7852 NNS denotes ligands
T6073 7841-7844 NNP denotes TLR
T6072 7837-7840 CC denotes and
T6071 7835-7836 , denotes ,
T6070 7830-7835 NNP denotes RANKL
T6069 7828-7829 , denotes ,
T6068 7820-7828 NNS denotes antigens
T6067 7818-7819 , denotes ,
T6066 7817-7818 -RRB- denotes )
T6065 7813-7817 NNP denotes IL-1
T6064 7811-7812 , denotes ,
T6063 7808-7811 NNP denotes TNF
T6062 7806-7807 , denotes ,
T6061 7799-7806 NN denotes example
T6060 7795-7798 IN denotes for
T6059 7794-7795 -LRB- denotes (
T6058 7784-7793 NNS denotes cytokines
T6057 7768-7783 JJ denotes proinflammatory
T6056 7758-7767 VBG denotes including
T6055 7750-7757 NNS denotes stimuli
T6054 7745-7749 JJ denotes many
T6053 7742-7744 IN denotes by
T6052 7732-7741 VBN denotes triggered
T6051 7729-7731 VBZ denotes is
T6050 7725-7728 CC denotes and
T6049 7723-7724 , denotes ,
T6048 7715-7723 NN denotes immunity
T6047 7706-7714 JJ denotes adaptive
T6046 7702-7705 CC denotes and
T6045 7695-7701 NN denotes innate
T6044 7692-7694 IN denotes in
T6043 7687-7691 NN denotes role
T6042 7681-7686 JJ denotes major
T6041 7679-7680 DT denotes a
T6040 7673-7678 VBZ denotes plays
T6039 7665-7672 NN denotes pathway
T6038 7659-7664 NN denotes NF-κB
T6037 7649-7658 JJ denotes canonical
T6036 7645-7648 DT denotes The
T6035 7643-7644 . denotes .
T6034 7635-7643 NNS denotes pathways
T6033 7629-7634 NN denotes NF-κB
T6032 7627-7628 -RRB- denotes )
T6031 7616-7627 NN denotes alternative
T6030 7613-7615 CC denotes or
T6029 7612-7613 -LRB- denotes (
T6028 7599-7611 JJ denotes noncanonical
T6027 7595-7598 CC denotes and
T6026 7593-7594 -RRB- denotes )
T6025 7584-7593 JJ denotes classical
T6024 7581-7583 CC denotes or
T6023 7580-7581 -LRB- denotes (
T6022 7570-7579 JJ denotes canonical
T6021 7563-7569 VBD denotes termed
T6020 7561-7562 , denotes ,
T6019 7553-7561 NNS denotes pathways
T6018 7542-7552 VBG denotes signalling
T6017 7536-7541 NN denotes NF-κB
T6016 7529-7535 JJ denotes unique
T6015 7525-7528 CD denotes two
T6014 7521-7524 VBP denotes are
T6013 7515-7520 EX denotes There
T6012 7513-7514 . denotes .
T6011 7501-7513 RB denotes respectively
T6010 7499-7500 , denotes ,
T6009 7491-7499 NNS denotes subunits
T6008 7485-7490 JJ denotes NF-κB
T6007 7481-7484 CD denotes p50
T6006 7477-7480 CC denotes and
T6005 7473-7476 CD denotes p52
T6004 7469-7472 DT denotes the
T6003 7466-7468 IN denotes of
T6002 7455-7465 NNS denotes precursors
T6001 7451-7454 VBP denotes are
T6000 7446-7450 NNS denotes p105
T5999 7442-7445 CC denotes and
T5998 7437-7441 NN denotes p100
T5997 7435-7436 . denotes .
T5996 7428-7435 NN denotes nucleus
T5995 7424-7427 DT denotes the
T5994 7421-7423 IN denotes in
T5993 7405-7420 NN denotes transactivation
T5992 7399-7404 NN denotes NF-κB
T5991 7388-7398 JJ denotes potentiate
T5990 7380-7387 RB denotes instead
T5989 7374-7379 JJ denotes Bcl-3
T5988 7370-7373 CC denotes and
T5987 7365-7369 NNP denotes IκBξ
T5986 7363-7364 , denotes ,
T5985 7358-7363 NNP denotes NF-κB
T5984 7355-7357 IN denotes of
T5983 7344-7354 NNS denotes inhibitors
T5982 7341-7343 IN denotes as
T5981 7335-7340 VBP denotes serve
T5980 7333-7334 -RRB- denotes )
T5979 7332-7333 -RRB- denotes )
T5978 7326-7332 NN denotes NF-κB2
T5977 7323-7325 IN denotes as
T5976 7317-7322 VBN denotes known
T5975 7312-7316 RB denotes also
T5974 7311-7312 -LRB- denotes (
T5973 7306-7310 NN denotes p100
T5972 7304-7305 , denotes ,
T6188 8497-8506 JJ denotes canonical
T6187 8493-8496 IN denotes for
T6186 8484-8492 VBN denotes required
T6185 8480-8483 VBP denotes are
T6184 8478-8479 , denotes ,
T6183 8474-8478 NNP denotes IKK1
T6182 8470-8473 RB denotes not
T6181 8466-8469 CC denotes but
T6180 8464-8465 , denotes ,
T6179 8460-8464 NNP denotes NEMO
T6178 8456-8459 CC denotes and
T6177 8451-8455 NNP denotes IKK2
T6176 8446-8450 IN denotes that
T6175 8439-8445 VBD denotes showed
T6174 8427-8438 NNS denotes experiments
T6173 8417-8426 VBG denotes targeting
T6172 8412-8416 NNP denotes Gene
T6171 8410-8411 . denotes .
T6170 8409-8410 -RRB- denotes )
T6169 8408-8409 CD denotes 1
T6168 8401-8407 NN denotes Figure
T6167 8400-8401 -LRB- denotes (
T6166 8398-8399 -RRB- denotes )
T6165 8394-8398 NNP denotes IKKγ
T6164 8391-8393 IN denotes as
T6163 8385-8390 VBN denotes known
T6162 8380-8384 RB denotes also
T3270 6984-6985 . denotes .
T3269 6982-6984 NNP denotes RA
T3268 6979-6981 IN denotes in
T3267 6968-6978 NN denotes expression
T3266 6963-6967 NN denotes gene
T3265 6950-6962 JJ denotes inflammatory
T3264 6946-6949 CC denotes and
T3263 6935-6945 NN denotes activation
T3262 6929-6934 JJ denotes NF-κB
T3261 6926-6928 TO denotes to
T3260 6915-6925 VB denotes contribute
T3259 6911-6914 MD denotes may
T3258 6904-6910 NN denotes tissue
T3257 6898-6903 JJ denotes joint
T3256 6889-6897 JJ denotes inflamed
T3255 6885-6888 DT denotes the
T3254 6882-6884 IN denotes in
T3253 6874-6881 NNS denotes ligands
T3252 6870-6873 NNP denotes TLR
T3251 6862-6869 JJ denotes several
T3250 6857-6861 IN denotes that
T3249 6849-6856 VBP denotes suggest
T3248 6841-6848 NNS denotes studies
T3247 6835-6840 DT denotes these
T3246 6833-6834 , denotes ,
T3245 6825-6833 RB denotes Together
T3244 6823-6824 . denotes .
T3243 6822-6823 -RRB- denotes )
T3242 6821-6822 NNP denotes ]
T3241 6816-6821 CD denotes 14,15
T3240 6815-6816 NNP denotes [
T3239 6812-6814 IN denotes in
T3238 6803-6811 VBN denotes reviewed
T3237 6802-6803 -LRB- denotes (
T3236 6792-6801 NNS denotes fragments
T3235 6787-6791 NN denotes acid
T3234 6775-6786 JJ denotes hyal-uronic
T3233 6771-6774 CC denotes and
T3232 6769-6770 , denotes ,
T3231 6768-6769 NNP denotes C
T3230 6759-6767 NN denotes tenascin
T3229 6757-6758 , denotes ,
T3228 6749-6757 NN denotes biglycan
T3227 6747-6748 , denotes ,
T3226 6736-6747 NN denotes fibronectin
T3225 6734-6735 , denotes ,
T3224 6724-6734 NN denotes fibrinogen
T3223 6721-6723 IN denotes as
T3222 6716-6720 JJ denotes such
T3221 6705-6715 NNS denotes components
T3220 6698-6704 NN denotes matrix
T3219 6684-6697 JJ denotes extracellular
T3218 6680-6683 VBP denotes are
T3217 6670-6679 NN denotes pathology
T3216 6667-6669 NNP denotes RA
T3215 6664-6666 IN denotes in
T3214 6655-6663 VBN denotes involved
T3213 6652-6654 VB denotes be
T3212 6648-6651 MD denotes may
T3211 6643-6647 WDT denotes that
T3210 6635-6642 NNS denotes ligands
T3209 6631-6634 NNP denotes TLR
T3208 6620-6630 JJ denotes endogenous
T3207 6614-6619 JJ denotes Other
T3206 6612-6613 . denotes .
T3205 6611-6612 NNP denotes ]
T3204 6606-6611 CD denotes 17,18
T3203 6605-6606 NNP denotes [
T3202 6602-6604 NNP denotes RA
T3201 6599-6601 IN denotes in
T3200 6586-6598 NN denotes inflammation
T3199 6578-6585 NN denotes chronic
T3198 6565-6577 JJ denotes TLR4-induced
T3197 6562-6564 IN denotes in
T3196 6553-6561 VBN denotes involved
T3195 6550-6552 VB denotes be
T3194 6547-6549 TO denotes to
T3193 6537-6546 VBN denotes suggested
T3192 6532-6536 VBN denotes been
T3191 6527-6531 VBP denotes have
T3190 6523-6526 CC denotes and
T3189 6521-6522 , denotes ,
T3188 6516-6521 NN denotes fluid
T3187 6507-6515 JJ denotes synovial
T3186 6504-6506 NNP denotes RA
T3185 6501-6503 IN denotes in
T3184 6493-6500 JJ denotes present
T3183 6482-6492 RB denotes abundantly
T3182 6477-6481 RB denotes also
T3181 6473-6476 VBP denotes are
T3180 6471-6472 , denotes ,
T3179 6463-6471 NNS denotes proteins
T3178 6447-6462 JJ denotes calcium-binding
T3177 6444-6446 IN denotes of
T3176 6437-6443 NN denotes family
T3175 6432-6436 NNP denotes S100
T3174 6428-6431 DT denotes the
T3173 6425-6427 TO denotes to
T3172 6415-6424 VBG denotes belonging
T3171 6405-6414 NNS denotes molecules
T3170 6397-6404 NN denotes pattern
T3169 6387-6396 JJ denotes molecular
T3168 6369-6386 JJ denotes damage-associated
T3167 6367-6368 , denotes ,
T3166 6365-6367 CD denotes 14
T3165 6357-6364 NN denotes protein
T3164 6341-6356 JJ denotes myeloid-related
T3163 6337-6340 CC denotes and
T3162 6335-6336 CD denotes 8
T3161 6327-6334 NN denotes protein
T3160 6311-6326 JJ denotes Myeloid-related
T3159 6309-6310 . denotes .
T3158 6308-6309 NNP denotes ]
T3157 6306-6308 CD denotes 16
T3156 6305-6306 NNP denotes [
T3155 6300-6304 NNS denotes mice
T3154 6297-6299 IN denotes in
T3153 6287-6296 NNS denotes arthritis
T3152 6270-6286 JJ denotes collagen-induced
T3151 6262-6269 IN denotes against
T3150 6254-6261 VBP denotes protect
T3149 6248-6253 NNP denotes HMGB1
T3148 6245-6247 IN denotes of
T3147 6238-6244 NN denotes domain
T3146 6233-6237 NNP denotes BoxA
T3145 6220-6232 JJ denotes antagonistic
T3144 6216-6219 DT denotes the
T3143 6213-6215 CC denotes or
T3142 6202-6212 NNS denotes antibodies
T3141 6189-6201 VBG denotes neutralising
T3140 6183-6188 NNP denotes HMGB1
T3139 6179-6182 CC denotes and
T3138 6172-6178 NN denotes tissue
T3137 6163-6171 JJ denotes synovial
T3136 6160-6162 NNP denotes RA
T3135 6157-6159 IN denotes in
T3134 6147-6156 VBN denotes increased
T3133 6144-6146 VBZ denotes is
T3132 6138-6143 CD denotes HMGB1
T3131 6136-6137 . denotes .
T3130 6127-6136 NN denotes pathology
T3129 6124-6126 NNP denotes RA
T3128 6121-6123 IN denotes in
T3119 6063-6066 CD denotes one
T3118 6060-6062 VBZ denotes is
T3117 6058-6059 , denotes ,
T3116 6053-6058 NNS denotes cells
T3115 6044-6052 JJ denotes necrotic
T3114 6041-6043 IN denotes by
T3113 6032-6040 VBN denotes released
T3112 6022-6031 RB denotes passively
T3111 6019-6021 CC denotes or
T3110 6007-6018 NNS denotes macrophages
T3109 6004-6006 IN denotes by
T3108 5995-6003 VBN denotes secreted
T3107 5986-5994 RB denotes actively
T3106 5983-5985 VB denotes be
T3105 5979-5982 MD denotes can
T3104 5974-5978 WDT denotes that
T3103 5964-5973 NN denotes component
T3102 5954-5963 NN denotes chromatin
T3101 5944-5953 VBN denotes conserved
T3100 5937-5943 RB denotes highly
T3099 5935-5936 DT denotes a
T3098 5933-5934 , denotes ,
T3097 5932-5933 -RRB- denotes )
T3096 5927-5932 CD denotes HMGB1
T3095 5926-5927 -LRB- denotes (
T3094 5924-5925 CD denotes 1
T3093 5916-5923 NN denotes protein
T3092 5904-5915 JJ denotes chromosomal
T3091 5900-5903 NN denotes box
T3090 5894-5899 NN denotes group
T3089 5885-5893 NN denotes mobility
T3088 5880-5884 NNP denotes High
T3087 5878-5879 . denotes .
T3086 5871-5878 NN denotes disease
T3085 5867-5870 DT denotes the
T3084 5864-5866 IN denotes of
T3083 5851-5863 NN denotes pathogenesis
T3082 5847-5850 DT denotes the
T3081 5844-5846 IN denotes in
T3080 5834-5843 JJ denotes important
T3079 5828-5833 VBG denotes being
T3078 5825-5827 IN denotes as
T3077 5812-5824 NN denotes inflammation
T3076 5798-5811 JJ denotes TLR-dependent
T3075 5789-5797 VB denotes identify
T3074 5781-5788 RB denotes clearly
T3073 5770-5780 VBG denotes signalling
T3072 5766-5769 NNP denotes TLR
T3071 5760-5765 VB denotes block
T3070 5757-5759 TO denotes to
T3069 5746-5756 NNS denotes strategies
T3068 5743-5745 CC denotes or
T3067 5738-5742 NNS denotes mice
T3066 5729-5737 NN denotes knockout
T3065 5725-5728 NNP denotes TLR
T3064 5719-5724 VBG denotes using
T3063 5712-5718 NNS denotes models
T3062 5705-5711 NN denotes animal
T3061 5703-5704 , denotes ,
T3060 5695-5703 RB denotes Moreover
T3059 5693-5694 . denotes .
T3058 5685-5693 NNS denotes patients
T3057 5682-5684 NNP denotes RA
T3056 5679-5681 IN denotes of
T3055 5672-5678 NNS denotes joints
T3054 5663-5671 JJ denotes inflamed
T3053 5659-5662 DT denotes the
T3052 5652-5658 IN denotes within
T3051 5644-5651 JJ denotes present
T3050 5640-5643 VBP denotes are
T3049 5632-5639 NNS denotes ligands
T3048 5621-5631 JJ denotes endogenous
T3047 5613-5620 JJ denotes various
T3046 5609-5612 CC denotes and
T3045 5601-5608 NNS denotes tissues
T3044 5592-5600 JJ denotes synovial
T3043 5589-5591 NNP denotes RA
T3042 5586-5588 IN denotes in
T3041 5576-5585 VBN denotes expressed
T3040 5572-5575 VBP denotes are
T3039 5567-5571 NNS denotes TLRs
T3038 5565-5566 . denotes .
T3037 5564-5565 -RRB- denotes )
T3036 5563-5564 NNP denotes ]
T3035 5558-5563 CD denotes 14,15
T3034 5557-5558 NNP denotes [
T3033 5554-5556 IN denotes in
T3032 5545-5553 VBN denotes reviewed
T3031 5544-5545 -LRB- denotes (
T3030 5531-5543 NN denotes inflammation
T3029 5523-5530 JJ denotes sterile
T3028 5513-5522 JJ denotes so-called
T3027 5504-5512 VBG denotes inducing
T3026 5499-5503 NNS denotes TLRs
T3025 5496-5498 IN denotes of
T3024 5485-5495 NNS denotes activators
T3023 5475-5484 NN denotes candidate
T3022 5472-5474 IN denotes as
T3021 5463-5471 VBN denotes reported
T3020 5458-5462 VBN denotes been
T3019 5453-5457 VB denotes have
T3018 5451-5452 : denotes -
T3017 5445-5450 NNS denotes cells
T3016 5441-5444 CC denotes and
T3015 5433-5440 NNS denotes tissues
T3014 5428-5432 NN denotes host
T3013 5423-5427 IN denotes from
T3012 5415-5422 VBN denotes derived
T3011 5406-5414 NNS denotes proteins
T3010 5403-5405 IN denotes of
T3009 5397-5402 NN denotes group
T3008 5395-5396 DT denotes a
T3007 5393-5394 : denotes -
T3006 5385-5392 NNS denotes ligands
T3005 5374-5384 JJ denotes endogenous
T3004 5371-5373 IN denotes of
T3003 5364-5370 NN denotes number
T3002 5353-5363 VBG denotes increasing
T3001 5350-5352 DT denotes an
T3000 5348-5349 , denotes ,
T2999 5341-5348 NNS denotes ligands
T2998 5331-5340 JJ denotes microbial
T2997 5328-5330 TO denotes to
T2996 5319-5327 NN denotes addition
T2995 5316-5318 IN denotes In
T2994 5314-5315 . denotes .
T2993 5312-5314 NNP denotes RA
T2992 5309-5311 IN denotes in
T2991 5296-5308 NN denotes inflammation
T2990 5280-5295 JJ denotes NF-κB-dependent
T2989 5271-5279 VBG denotes inducing
T2988 5267-5270 IN denotes for
T2987 5256-5266 NNS denotes candidates
T2986 5246-5255 JJ denotes potential
T2985 5242-5245 VBP denotes are
T2984 5238-5241 CC denotes and
T2983 5229-5237 NNS denotes diseases
T2982 5218-5228 JJ denotes autoimmune
T2981 5215-5217 IN denotes of
T2980 5207-5214 NN denotes variety
T2979 5205-5206 DT denotes a
T2978 5202-5204 IN denotes in
T2977 5191-5201 VBN denotes implicated
T2976 5186-5190 VBN denotes been
T2975 5181-5185 VBP denotes have
T2974 5179-5180 -RRB- denotes )
T2973 5175-5179 NNS denotes TLRs
T2972 5174-5175 -LRB- denotes (
T2971 5164-5173 NNS denotes receptors
T2970 5154-5163 JJ denotes Toll-like
T2969 5152-5153 . denotes .
T2968 5151-5152 NNP denotes ]
T2967 5149-5151 CD denotes 13
T2966 5148-5149 NNP denotes [
T2965 5145-5147 NNP denotes RA
T2964 5135-5144 VBG denotes including
T2963 5122-5134 NN denotes inflammation
T2962 5114-5121 JJ denotes chronic
T2961 5111-5113 IN denotes of
T2960 5105-5110 NNS denotes sites
T2959 5102-5104 IN denotes at
T2958 5092-5101 NN denotes formation
T2957 5086-5091 NN denotes organ
T2956 5077-5085 JJ denotes lymphoid
T2955 5068-5076 JJ denotes tertiary
T2954 5065-5067 IN denotes in
T2953 5054-5064 VBN denotes implicated
T2952 5049-5053 VBN denotes been
T2951 5045-5048 VBZ denotes has
T2950 5034-5044 NN denotes signalling
T2949 5025-5033 NN denotes receptor
T2948 5023-5024 NN denotes β
T2947 5011-5022 NN denotes lymphotoxin
T2946 5009-5010 , denotes ,
T2945 5002-5009 RB denotes Finally
T2944 5000-5001 . denotes .
T2943 4999-5000 NNP denotes ]
T2942 4997-4999 CD denotes 13
T2941 4996-4997 NNP denotes [
T2940 4993-4995 NNP denotes RA
T2939 4985-4992 VB denotes counter
T2938 4982-4984 TO denotes to
T2937 4972-4981 VBN denotes developed
T2936 4967-4971 VBN denotes been
T2935 4962-4966 VBP denotes have
T2934 4957-4961 NNP denotes BAFF
T2933 4954-4956 IN denotes of
T2932 4942-4953 NNS denotes antagonists
T2931 4938-4941 CC denotes and
T2930 4936-4937 , denotes ,
T2929 4934-4936 NNP denotes RA
T2928 4930-4933 IN denotes for
T2927 4915-4929 JJ denotes characteristic
T2926 4910-4914 RB denotes also
T2925 4907-4909 VBZ denotes is
T2924 4905-4906 , denotes ,
T2923 4894-4905 NNS denotes lymphocytes
T2922 4892-4893 NNP denotes B
T2921 4882-4891 VBG denotes producing
T2920 4880-4881 : denotes -
T2919 4868-4880 NN denotes autoantibody
T2918 4865-4867 IN denotes of
T2917 4856-4864 NN denotes survival
T2916 4852-4855 DT denotes the
T2915 4843-4851 VBG denotes allowing
T2914 4841-4842 , denotes ,
T2913 4840-4841 -RRB- denotes )
T2912 4836-4840 NNP denotes BAFF
T2911 4835-4836 -LRB- denotes (
T2910 4828-4834 NN denotes factor
T2909 4817-4827 VBG denotes activating
T2908 4810-4816 NNP denotes B-cell
T2907 4803-4809 NN denotes member
T2906 4796-4802 NN denotes family
T2905 4787-4795 NN denotes receptor
T2904 4783-4786 NNP denotes TNF
T2892 4716-4726 NNS denotes antibodies
T2891 4705-4715 JJ denotes pathogenic
T2890 4701-4704 CC denotes and
T2889 4689-4700 VBN denotes established
T2888 4686-4688 VBZ denotes is
T2887 4678-4685 NN denotes disease
T2886 4673-4677 RB denotes once
T2885 4664-4672 VBN denotes required
T2884 4660-4663 RB denotes not
T2883 4656-4659 VBP denotes are
T2882 4652-4655 CC denotes but
T2881 4650-4651 , denotes ,
T2880 4641-4650 NN denotes induction
T2879 4631-4640 NN denotes arthritis
T2878 4628-4630 IN denotes of
T2877 4621-4627 NNS denotes stages
T2876 4613-4620 JJ denotes initial
T2875 4609-4612 DT denotes the
T2874 4606-4608 IN denotes at
T2873 4596-4605 JJ denotes important
T2872 4593-4595 VB denotes be
T2871 4589-4592 MD denotes may
T2870 4581-4588 NNS denotes signals
T2869 4576-4580 NNP denotes CD40
T2868 4571-4575 WDT denotes that
T2867 4560-4570 NN denotes conclusion
T2866 4556-4559 DT denotes the
T2865 4553-4555 TO denotes to
T2864 4549-4552 VBD denotes led
T2863 4538-4548 NNS denotes antibodies
T2862 4527-4537 JJ denotes anti-CD154
T2861 4524-4526 CC denotes or
T2860 4514-4523 JJ denotes anti-CD40
T2859 4501-4513 JJ denotes antagonistic
T2858 4496-4500 IN denotes with
T2857 4488-4495 NNS denotes studies
T2856 4486-4487 , denotes ,
T2855 4479-4486 RB denotes However
T2854 4477-4478 . denotes .
T2853 4466-4477 NN denotes destruction
T2852 4460-4465 JJ denotes joint
T2851 4457-4459 TO denotes to
T2850 4445-4456 VBZ denotes contributes
T2849 4439-4444 WDT denotes which
T2848 4437-4438 , denotes ,
T2847 4427-4437 NNS denotes chemokines
T2846 4423-4426 CC denotes and
T2845 4413-4422 NNS denotes cytokines
T2844 4397-4412 JJ denotes proinflammatory
T2843 4394-4396 IN denotes of
T2842 4384-4393 NN denotes secretion
T2841 4380-4383 CC denotes and
T2840 4366-4379 NN denotes proliferation
T2839 4355-4365 NN denotes fibroblast
T2838 4352-4354 IN denotes in
T2837 4342-4351 VBG denotes resulting
T2836 4331-4341 NN denotes activation
T2835 4325-4330 NNP denotes NF-κB
T2834 4316-4324 VBZ denotes triggers
T2833 4314-4315 , denotes ,
T2832 4309-4314 NNS denotes cells
T2831 4307-4308 NNP denotes T
T2830 4305-4306 CD denotes +
T2829 4302-4305 NNP denotes CD4
T2828 4292-4301 VBN denotes activated
T2827 4289-4291 IN denotes of
T2826 4281-4288 NN denotes surface
T2825 4277-4280 DT denotes the
T2824 4274-4276 IN denotes on
T2823 4264-4273 VBN denotes expressed
T2822 4252-4263 RB denotes transiently
T2821 4249-4251 VBZ denotes is
T2820 4243-4248 WDT denotes which
T2819 4241-4242 , denotes ,
T2818 4240-4241 -RRB- denotes )
T2817 4235-4240 NNP denotes CD154
T2816 4234-4235 -LRB- denotes (
T2815 4227-4233 NN denotes ligand
T2814 4222-4226 NNP denotes CD40
T2813 4218-4221 DT denotes the
T2812 4215-4217 IN denotes of
T2811 4207-4214 VBG denotes Binding
T2810 4205-4206 . denotes .
T2809 4204-4205 NNP denotes ]
T2808 4202-4204 CD denotes 10
T2807 4201-4202 NNP denotes [
T2806 4197-4200 NNP denotes TNF
T2805 4187-4196 VBG denotes including
T2804 4177-4186 NNS denotes cytokines
T2803 4161-4176 JJ denotes proinflammatory
T2802 4158-4160 IN denotes by
T2801 4146-4157 VBN denotes upregulated
T2800 4143-4145 VB denotes be
T2799 4139-4142 MD denotes can
T2798 4135-4138 CC denotes and
T2797 4133-4134 , denotes ,
T2796 4128-4133 NNS denotes cells
T2795 4118-4127 JJ denotes dendritic
T2794 4114-4117 CC denotes and
T2793 4112-4113 , denotes ,
T3127 6112-6120 VBN denotes involved
T3126 6104-6111 NNS denotes ligands
T3125 6099-6103 CD denotes TLR4
T3124 6088-6098 JJ denotes endogenous
T3123 6079-6087 JJ denotes putative
T3122 6074-6078 RBS denotes most
T3121 6070-6073 DT denotes the
T3120 6067-6069 IN denotes of
T2792 4101-4112 NNS denotes macrophages
T2791 4099-4100 , denotes ,
T2790 4094-4099 NNS denotes cells
T2789 4092-4093 NNP denotes B
T2788 4090-4091 , denotes ,
T2787 4085-4090 NNS denotes cells
T2786 4076-4084 JJ denotes synovial
T2785 4073-4075 NNP denotes RA
T2784 4069-4072 CC denotes and
T2783 4060-4068 NNS denotes patients
T2782 4057-4059 NNP denotes RA
T2781 4053-4056 CC denotes and
T2780 4046-4052 JJ denotes normal
T2779 4041-4045 IN denotes from
T2778 4029-4040 NNS denotes fibroblasts
T2777 4022-4028 NN denotes muscle
T2776 4015-4021 JJ denotes smooth
T2775 4005-4014 VBG denotes including
T2774 4003-4004 , denotes ,
T2773 3998-4003 NNS denotes types
T2772 3993-3997 NN denotes cell
T2771 3990-3992 IN denotes of
T2770 3982-3989 NN denotes variety
T2769 3980-3981 DT denotes a
T2768 3977-3979 IN denotes on
T2767 3967-3976 VBN denotes expressed
T2766 3954-3966 RB denotes functionally
T2765 3951-3953 VBZ denotes is
T2764 3946-3950 WDT denotes that
T2763 3939-3945 NN denotes member
T2762 3932-3938 NN denotes family
T2761 3923-3931 NN denotes receptor
T2760 3919-3922 NN denotes TNF
T2759 3911-3918 DT denotes another
T2758 3908-3910 VBZ denotes is
T2757 3903-3907 CD denotes CD40
T2756 3901-3902 . denotes .
T2755 3900-3901 NNP denotes ]
T2754 3899-3900 CD denotes 7
T2753 3898-3899 NN denotes [
T2752 3893-3897 NN denotes loss
T2751 3888-3892 NN denotes bone
T2750 3883-3887 IN denotes with
T2749 3872-3882 VBN denotes associated
T2748 3863-3871 NNS denotes diseases
T2747 3857-3862 JJ denotes other
T2746 3853-3856 CC denotes and
T2745 3843-3852 NN denotes pathology
T2744 3840-3842 NNP denotes RA
T2743 3837-3839 IN denotes in
T2742 3828-3836 VBN denotes involved
T2741 3825-3827 VB denotes be
T2740 3822-3824 TO denotes to
T2739 3815-3821 JJ denotes likely
T2738 3811-3814 VBP denotes are
T2737 3800-3810 VBG denotes signalling
T2736 3789-3799 NN denotes RANK-NF-κB
T2735 3782-3788 JJ denotes proper
T2734 3779-3781 IN denotes in
T2733 3771-3778 NNS denotes defects
T2732 3767-3770 CC denotes and
T2731 3765-3766 , denotes ,
T2730 3747-3765 NN denotes osteoclastogenesis
T2729 3743-3746 IN denotes for
T2728 3733-3742 JJ denotes important
T2727 3730-3732 VBZ denotes is
T2726 3728-3729 , denotes ,
T2725 3722-3728 NN denotes member
T2724 3715-3721 NN denotes family
T2723 3706-3714 NN denotes receptor
T2722 3702-3705 NNP denotes TNF
T2721 3700-3701 DT denotes a
T2720 3698-3699 , denotes ,
T2719 3697-3698 -RRB- denotes )
T2718 3693-3697 NNP denotes RANK
T2717 3692-3693 -LRB- denotes (
T2716 3686-3691 NNP denotes NF-κB
T2715 3683-3685 IN denotes of
T2714 3673-3682 NN denotes activator
T2713 3664-3672 NN denotes receptor
T2712 3661-3663 IN denotes by
T2711 3650-3660 NN denotes activation
T2710 3644-3649 JJ denotes NF-κB
T2709 3642-3643 . denotes .
T2708 3641-3642 -RRB- denotes )
T2707 3640-3641 NNP denotes ]
T2706 3639-3640 CD denotes 3
T2705 3638-3639 NNP denotes [
T2704 3635-3637 IN denotes in
T2703 3626-3634 VBN denotes reviewed
T2702 3625-3626 -LRB- denotes (
T2701 3622-3624 NNP denotes RA
T2700 3619-3621 IN denotes in
T2699 3608-3618 NNS denotes activities
T2698 3591-3607 JJ denotes pro-inflammatory
T2697 3585-3590 PRP$ denotes their
T2696 3582-3584 IN denotes of
T2695 3577-3581 JJS denotes most
T2694 3568-3576 VBZ denotes mediates
T2693 3558-3567 NNS denotes cytokines
T2692 3552-3557 DT denotes these
T2691 3549-3551 IN denotes by
T2690 3538-3548 NN denotes activation
T2689 3532-3537 JJ denotes NF-κB
T2688 3527-3531 DT denotes that
T2687 3518-3526 VBN denotes expected
T2686 3515-3517 VB denotes be
T2685 3511-3514 MD denotes can
T2684 3508-3510 PRP denotes it
T2683 3504-3507 CC denotes and
T2682 3498-3503 NN denotes NF-κB
T2681 3495-3497 IN denotes of
T2680 3484-3494 NNS denotes activators
T2679 3477-3483 JJ denotes potent
T2678 3472-3476 RB denotes very
T2677 3467-3471 DT denotes both
T2633 3250-3252 IN denotes in
T2632 3244-3249 NN denotes NF-κB
T2631 3235-3243 VBP denotes activate
T2630 3230-3234 IN denotes that
T2629 3221-3229 VBZ denotes triggers
T2628 3211-3220 JJ denotes molecular
T2627 3207-3210 DT denotes the
T2626 3204-3206 IN denotes of
T2625 3189-3203 NN denotes identification
T2624 3185-3188 DT denotes the
T2623 3180-3184 IN denotes with
T2622 3174-3179 NNS denotes deals
T2621 3165-3173 NN denotes research
T2620 3160-3164 JJ denotes much
T2619 3158-3159 , denotes ,
T2618 3156-3158 NNP denotes RA
T2617 3153-3155 IN denotes in
T2616 3140-3152 NN denotes inflammation
T2615 3137-3139 IN denotes of
T2614 3129-3136 NN denotes process
T2613 3125-3128 DT denotes the
T2612 3122-3124 TO denotes to
T2611 3114-3121 JJ denotes central
T2610 3111-3113 VBZ denotes is
T2609 3105-3110 NNP denotes NF-κB
T2608 3099-3104 IN denotes Since
T2903 4779-4782 DT denotes the
T2902 4776-4778 IN denotes of
T2901 4765-4775 NN denotes expression
T2900 4756-4764 VBN denotes Enhanced
T2899 4754-4755 . denotes .
T2898 4753-4754 NNP denotes ]
T2897 4748-4753 CD denotes 11,12
T2896 4747-4748 NNP denotes [
T2895 4739-4746 JJ denotes present
T2894 4731-4738 RB denotes already
T2893 4727-4730 VBP denotes are
T2676 3463-3466 VBP denotes are
T2675 3458-3462 NNP denotes IL-1
T2674 3454-3457 CC denotes and
T2673 3450-3453 NNP denotes TNF
T2672 3448-3449 . denotes .
T2671 3447-3448 -RRB- denotes )
T2670 3446-3447 NNP denotes ]
T2669 3445-3446 CD denotes 9
T2668 3444-3445 NNP denotes [
T2667 3441-3443 IN denotes in
T2666 3432-3440 VBN denotes reviewed
T2665 3431-3432 -LRB- denotes (
T2664 3428-3430 NNP denotes RA
T2663 3421-3427 JJ denotes severe
T2662 3417-3420 IN denotes for
T2661 3407-3416 NN denotes treatment
T2660 3397-3406 JJ denotes effective
T2659 3394-3396 DT denotes an
T2658 3391-3393 VBZ denotes is
T2657 3379-3390 NNS denotes antagonists
T2656 3375-3378 NNP denotes TNF
T2655 3372-3374 IN denotes of
T2654 3357-3371 NN denotes administration
T2653 3353-3356 CC denotes and
T2652 3351-3352 , denotes ,
T2651 3347-3351 NN denotes role
T2650 3337-3346 JJ denotes important
T2649 3334-3336 DT denotes an
T2648 3329-3333 VBP denotes play
T2647 3324-3328 NNP denotes IL-1
T2646 3320-3323 CC denotes and
T2645 3316-3319 NNP denotes TNF
T2644 3313-3315 IN denotes as
T2643 3308-3312 JJ denotes such
T2642 3298-3307 NNS denotes cytokines
T2641 3282-3297 JJ denotes proinflammatory
T2640 3277-3281 IN denotes that
T2639 3268-3276 VBN denotes accepted
T2638 3263-3267 RB denotes well
T2637 3260-3262 VBZ denotes is
T2636 3257-3259 PRP denotes It
T2635 3255-3256 . denotes .
T2634 3253-3255 NNP denotes RA
T1246 3048-3049 . denotes .
T1245 3047-3048 NNP denotes ]
T1244 3046-3047 CD denotes 8
T1243 3045-3046 NN denotes [
T1242 3032-3044 NN denotes pathogenesis
T1241 3029-3031 NNP denotes RA
T1240 3026-3028 IN denotes in
T1239 3015-3025 NN denotes activation
T1238 3009-3014 JJ denotes NF-κB
T1237 3006-3008 IN denotes of
T1236 2995-3005 NN denotes importance
T1235 2991-2994 DT denotes the
T1234 2981-2990 NN denotes highlight
T1233 2973-2980 JJ denotes further
T1232 2971-2972 , denotes ,
T1231 2966-2971 NNP denotes c-REL
T1230 2962-2965 CC denotes and
T1229 2960-2961 , denotes ,
T1228 2953-2960 CD denotes TNFAIP3
T1227 2951-2952 , denotes ,
T1226 2946-2951 CD denotes TRAF1
T1225 2944-2945 , denotes ,
T1224 2940-2944 NNP denotes CD40
T1223 2930-2939 VBG denotes including
T1222 2928-2929 , denotes ,
T1221 2918-2928 NN denotes signalling
T1220 2912-2917 JJ denotes NF-κB
T1219 2909-2911 TO denotes to
T1218 2900-2908 JJ denotes relevant
T1217 2894-2899 NNS denotes genes
T1216 2886-2893 JJ denotes several
T1215 2881-2885 IN denotes with
T1214 2869-2880 NN denotes association
T1213 2861-2868 JJ denotes genetic
T1212 2859-2860 DT denotes a
T1211 2849-2858 VBG denotes revealing
T1210 2837-2848 NNS denotes discoveries
T1209 2830-2836 JJ denotes recent
T1208 2828-2829 , denotes ,
T1207 2821-2828 RB denotes Finally
T1206 2819-2820 . denotes .
T1205 2818-2819 NNP denotes ]
T1204 2817-2818 CD denotes 7
T1203 2816-2817 NNP denotes [
T1202 2813-2815 NNP denotes RA
T1201 2810-2812 IN denotes as
T1200 2805-2809 JJ denotes such
T1132 2410-2412 TO denotes to
T1131 2402-2409 VBZ denotes appears
T1130 2391-2401 NN denotes activation
T1129 2385-2390 JJ denotes NF-κB
T1128 2382-2384 IN denotes of
T1127 2375-2381 NN denotes course
T1126 2370-2374 NN denotes time
T1125 2366-2369 DT denotes The
T1124 2364-2365 . denotes .
T1123 2363-2364 -RRB- denotes )
T1122 2362-2363 NNP denotes ]
T1121 2361-2362 CD denotes 4
T1120 2360-2361 NNP denotes [
T1119 2357-2359 IN denotes in
T1118 2348-2356 VBN denotes reviewed
T1117 2347-2348 -LRB- denotes (
T1116 2344-2346 NNP denotes RA
T1115 2341-2343 IN denotes of
T1114 2329-2340 NN denotes progression
T1113 2325-2328 CC denotes and
T1112 2313-2324 NN denotes development
T1111 2309-2312 DT denotes the
T1110 2306-2308 IN denotes in
T1109 2300-2305 NN denotes NF-κB
T1108 2297-2299 IN denotes of
T1107 2292-2296 NN denotes role
T1106 2285-2291 JJ denotes active
T1105 2281-2284 DT denotes the
T1104 2269-2280 VBP denotes demonstrate
T1103 2264-2268 RB denotes also
T1102 2254-2263 NNS denotes arthritis
T1101 2241-2253 JJ denotes inflammatory
T1100 2238-2240 IN denotes of
T1099 2231-2237 NNS denotes models
T1098 2224-2230 NN denotes animal
T1097 2220-2223 CC denotes and
T1096 2218-2219 , denotes ,
T1095 2210-2218 NNS denotes patients
T1094 2207-2209 NNP denotes RA
T1093 2202-2206 IN denotes from
T1092 2195-2201 NN denotes tissue
T1091 2186-2194 JJ denotes synovial
T1090 2182-2185 CC denotes and
T1089 2170-2181 NNS denotes fibroblasts
T1088 2161-2169 JJ denotes synovial
T1087 2152-2160 JJ denotes cultured
T1086 2149-2151 IN denotes in
T1085 2140-2148 VBN denotes detected
T1084 2137-2139 VB denotes be
T1083 2133-2136 MD denotes can
T1082 2122-2132 NN denotes activation
T1081 2116-2121 JJ denotes NF-κB
T1080 2114-2115 . denotes .
T1079 2113-2114 -RRB- denotes )
T1078 2112-2113 NNP denotes ]
T1077 2109-2112 CD denotes 2,3
T1076 2108-2109 NNP denotes [
T1075 2105-2107 IN denotes in
T1074 2096-2104 VBN denotes reviewed
T1073 2095-2096 -LRB- denotes (
T1072 2089-2094 NNP denotes NF-κB
T1071 2086-2088 IN denotes of
T1070 2075-2085 NNS denotes activators
T1069 2068-2074 JJ denotes potent
T1068 2063-2067 RB denotes very
T1067 2052-2062 PRP denotes themselves
T1066 2048-2051 VBP denotes are
T1065 2043-2047 NNP denotes IL-1
T1064 2039-2042 CC denotes and
T1063 2035-2038 NNP denotes TNF
T1062 2033-2034 , denotes ,
T1061 2025-2033 NN denotes addition
T1060 2022-2024 IN denotes In
T1059 2020-2021 . denotes .
T1058 2018-2020 NNP denotes RA
T1057 2015-2017 IN denotes in
T1056 2006-2014 VBN denotes involved
T1055 2002-2005 VBP denotes are
T1054 1997-2001 WDT denotes that
T1053 1995-1996 : denotes -
T1052 1976-1994 NNS denotes metalloproteinases
T1051 1969-1975 NN denotes matrix
T1050 1965-1968 CC denotes and
T1049 1963-1964 , denotes ,
T1048 1955-1963 NN denotes synthase
T1047 1949-1954 NN denotes oxide
T1046 1942-1948 JJ denotes nitric
T1045 1932-1941 JJ denotes inducible
T1044 1930-1931 , denotes ,
T1043 1920-1930 NNS denotes chemokines
T1042 1918-1919 , denotes ,
T1041 1901-1918 JJ denotes cyclo-oxygenase-2
T1040 1899-1900 , denotes ,
T1039 1895-1899 NNP denotes IL-6
T1038 1893-1894 , denotes ,
T1037 1889-1893 NNP denotes IL-1
T1036 1887-1888 , denotes ,
T1035 1884-1887 NNP denotes TNF
T1034 1881-1883 IN denotes as
T1033 1876-1880 JJ denotes such
T1032 1874-1875 : denotes -
T1031 1868-1873 NNS denotes genes
T1030 1865-1867 IN denotes of
T1029 1858-1864 NN denotes number
T1028 1852-1857 JJ denotes large
T1027 1850-1851 DT denotes a
T1026 1847-1849 IN denotes of
T1025 1836-1846 NN denotes expression
T1024 1832-1835 DT denotes the
T1023 1823-1831 VB denotes regulate
T1022 1818-1822 IN denotes that
T1021 1814-1817 CC denotes and
T1020 1812-1813 , denotes ,
T1019 1811-1812 NNP denotes ]
T1018 1810-1811 CD denotes 1
T1017 1809-1810 VBP denotes [
T1016 1796-1808 NNS denotes heterodimers
T1015 1793-1795 CC denotes or
T1014 1782-1792 NNS denotes homodimers
T1013 1779-1781 IN denotes as
T1012 1770-1778 VBP denotes function
T1011 1765-1769 WDT denotes that
T1010 1763-1764 -RRB- denotes )
T1009 1758-1763 NNP denotes c-Rel
T1008 1756-1757 , denotes ,
T1007 1752-1756 NNP denotes RelB
T1006 1750-1751 , denotes ,
T1005 1746-1750 NNP denotes RelA
T1004 1743-1745 CC denotes or
T1003 1739-1742 CD denotes p65
T1002 1737-1738 , denotes ,
T1001 1731-1737 NNP denotes NF-κB1
T1000 1728-1730 CC denotes or
T999 1723-1727 CD denotes p105
T998 1721-1722 , denotes ,
T997 1715-1721 NNP denotes NF-κB2
T996 1712-1714 CC denotes or
T995 1707-1711 CD denotes p100
T994 1706-1707 -LRB- denotes (
T993 1697-1705 NNS denotes proteins
T992 1687-1696 VBD denotes conserved
T991 1672-1686 RB denotes evolutionarily
T990 1668-1671 CC denotes and
T989 1660-1667 VBN denotes related
T988 1647-1659 RB denotes structurally
T987 1644-1646 IN denotes of
T986 1637-1643 NN denotes family
T985 1635-1636 DT denotes a
T984 1624-1634 VBZ denotes represents
T983 1618-1623 NN denotes NF-κB
T982 1616-1617 . denotes .
T981 1608-1616 NNS denotes diseases
T980 1597-1607 JJ denotes autoimmune
T979 1591-1596 JJ denotes other
T978 1586-1590 JJ denotes many
T977 1582-1585 CC denotes and
T976 1579-1581 NNP denotes RA
T975 1576-1578 IN denotes of
T974 1564-1575 NN denotes development
T973 1560-1563 DT denotes the
T972 1557-1559 IN denotes in
T971 1552-1556 NN denotes role
T970 1548-1551 JJ denotes key
T969 1546-1547 DT denotes a
T968 1540-1545 VBZ denotes plays
T967 1529-1539 NN denotes expression
T966 1524-1528 NN denotes gene
T965 1508-1523 JJ denotes NF-κB-dependent
T964 1505-1507 IN denotes of
T963 1494-1504 NN denotes activation
T962 1489-1493 IN denotes that
T961 1480-1488 VBN denotes accepted
T960 1475-1479 RB denotes well
T959 1472-1474 VBZ denotes is
T958 1469-1471 PRP denotes it
T957 1465-1468 CC denotes but
T956 1463-1464 , denotes ,
T955 1453-1463 VBN denotes understood
T954 1449-1452 RB denotes not
T953 1443-1448 RB denotes still
T952 1440-1442 VBZ denotes is
T951 1437-1439 NNP denotes RA
T950 1434-1436 IN denotes of
T949 1424-1433 NN denotes aetiology
T948 1420-1423 DT denotes The
T947 1418-1419 . denotes .
T946 1414-1418 NN denotes bone
T945 1402-1413 JJ denotes subchondral
T944 1398-1401 CC denotes and
T943 1388-1397 NN denotes cartilage
T942 1378-1387 JJ denotes articular
T941 1369-1377 VBZ denotes degrades
T940 1365-1368 CC denotes and
T939 1357-1364 VBZ denotes invades
T938 1351-1356 WDT denotes which
T937 1349-1350 , denotes ,
T936 1343-1349 NN denotes tissue
T935 1336-1342 NN denotes pannus
T934 1333-1335 IN denotes of
T933 1323-1332 NN denotes formation
T932 1319-1322 DT denotes the
T931 1316-1318 TO denotes to
T883 993-1003 NN denotes disability
T882 989-992 CC denotes and
T881 981-988 NN denotes decline
T880 970-980 JJ denotes functional
T879 967-969 TO denotes to
T878 959-966 VBG denotes leading
T877 957-958 , denotes ,
T876 953-957 NN denotes bone
T875 949-952 CC denotes and
T874 939-948 NN denotes cartilage
T873 936-938 IN denotes of
T872 924-935 NN denotes destruction
T871 912-923 JJ denotes progressive
T870 910-911 DT denotes a
T869 905-909 IN denotes with
T868 894-904 VBN denotes associated
T867 891-893 VBZ denotes is
T833 698-707 NNS denotes arthritis
T832 687-697 JJ denotes Rheumatoid
T1199 2796-2804 NNS denotes diseases
T1198 2785-2795 JJ denotes osteolytic
T1197 2782-2784 IN denotes in
T1196 2774-2781 NN denotes erosion
T1195 2769-2773 NN denotes bone
T1194 2766-2768 IN denotes of
T1193 2760-2765 NN denotes cause
T1192 2754-2759 JJ denotes major
T1191 2750-2753 DT denotes the
T1190 2746-2749 VBP denotes are
T1189 2727-2745 NN denotes osteoclastogenesis
T1188 2724-2726 IN denotes of
T1187 2713-2723 NN denotes regulation
T1186 2709-2712 DT denotes the
T1185 2706-2708 IN denotes in
T1184 2698-2705 NNS denotes Defects
T1183 2696-2697 . denotes .
T1182 2695-2696 -RRB- denotes )
T1181 2690-2695 NNP denotes RANKL
T1180 2689-2690 -LRB- denotes (
T1179 2682-2688 NN denotes ligand
T1178 2676-2681 JJ denotes NF-κB
T1177 2673-2675 IN denotes of
T1176 2663-2672 NN denotes activator
T1175 2654-2662 NN denotes receptor
T1174 2651-2653 IN denotes of
T1173 2643-2650 NNS denotes effects
T1172 2639-2642 DT denotes the
T1171 2629-2638 VBG denotes mediating
T1170 2626-2628 IN denotes by
T1169 2619-2625 RB denotes mainly
T1168 2617-2618 , denotes ,
T1167 2599-2617 NN denotes osteoclastogenesis
T1166 2595-2598 IN denotes for
T1165 2585-2594 JJ denotes essential
T1164 2580-2584 RB denotes also
T1163 2577-2579 VBZ denotes is
T1162 2571-2576 NNP denotes NF-κB
T1161 2569-2570 , denotes ,
T1160 2559-2569 NN denotes expression
T1159 2554-2558 NN denotes gene
T1158 2538-2553 JJ denotes proinflammatory
T1157 2535-2537 IN denotes in
T1156 2530-2534 NN denotes role
T1155 2526-2529 PRP$ denotes its
T1154 2523-2525 TO denotes to
T1153 2518-2522 JJ denotes Next
T1152 2516-2517 . denotes .
T1151 2515-2516 NNP denotes ]
T1150 2512-2515 CD denotes 5,6
T1149 2511-2512 NNP denotes [
T1148 2502-2510 NN denotes severity
T1147 2494-2501 NN denotes disease
T1146 2484-2493 VBZ denotes decreases
T1145 2478-2483 NNS denotes means
T1144 2468-2477 JJ denotes different
T1143 2465-2467 IN denotes by
T1142 2459-2464 NN denotes NF-κB
T1141 2456-2458 IN denotes of
T1140 2447-2455 NN denotes blockade
T1139 2443-2446 CC denotes and
T1138 2441-2442 , denotes ,
T1137 2434-2441 NN denotes disease
T1136 2431-2433 IN denotes of
T1135 2425-2430 NN denotes onset
T1134 2421-2424 DT denotes the
T1133 2413-2420 VB denotes precede
T210 671-672 . denotes .
T209 662-671 NNS denotes arthritis
T208 651-661 JJ denotes rheumatoid
T207 648-650 IN denotes of
T206 635-647 NN denotes pathogenesis
T205 631-634 DT denotes the
T204 628-630 IN denotes in
T203 617-627 VBN denotes implicated
T202 612-616 VBN denotes been
T201 607-611 VBP denotes have
T200 601-606 WDT denotes which
T199 597-600 CC denotes and
T198 586-596 NN denotes signalling
T197 580-585 JJ denotes NF-κB
T196 572-579 VB denotes control
T195 569-571 TO denotes to
T194 561-568 VBN denotes evolved
T193 556-560 VBP denotes have
T192 551-555 WDT denotes that
T191 540-550 NNS denotes mechanisms
T190 529-539 JJ denotes regulatory
T189 520-528 JJ denotes negative
T188 512-519 JJ denotes various
T187 505-511 VB denotes review
T186 500-504 MD denotes will
T185 497-499 PRP denotes we
T184 492-496 RB denotes Here
T183 490-491 . denotes .
T182 481-490 NNS denotes responses
T181 475-480 JJ denotes NF-κB
T180 472-474 IN denotes of
T179 460-471 NN denotes termination
T178 451-459 VBG denotes ensuring
T177 440-450 NNS denotes regulators
T176 431-439 NN denotes feedback
T175 422-430 JJ denotes negative
T174 419-421 IN denotes of
T173 408-418 NN denotes repertoire
T172 406-407 DT denotes a
T171 396-405 VBG denotes including
T170 394-395 , denotes ,
T169 389-394 NN denotes check
T168 386-388 IN denotes in
T167 375-385 NN denotes signalling
T166 369-374 JJ denotes NF-κB
T165 364-368 VB denotes keep
T164 361-363 TO denotes to
T163 354-360 NN denotes system
T162 346-353 NN denotes control
T161 333-345 JJ denotes multilayered
T160 331-332 DT denotes a
T159 324-330 VBP denotes employ
T158 318-323 NNS denotes Cells
T157 316-317 . denotes .
T156 307-316 NNS denotes arthritis
T155 296-306 JJ denotes rheumatoid
T154 286-295 VBG denotes including
T153 284-285 , denotes ,
T152 276-284 NNS denotes diseases
T151 263-275 JJ denotes inflammatory
T150 259-262 CC denotes and
T149 248-258 JJ denotes autoimmune
T148 243-247 JJ denotes many
T147 238-242 IN denotes with
T146 231-237 VBN denotes linked
T145 226-230 VBN denotes been
T144 222-225 VBZ denotes has
T143 213-221 NN denotes activity
T142 207-212 NN denotes NF-κB
T141 193-206 JJ denotes inappropriate
T140 189-192 CC denotes and
T139 187-188 , denotes ,
T138 178-187 NNS denotes responses
T137 172-177 NN denotes mmune
T136 168-171 CC denotes and
T135 155-167 NN denotes inflammation
T134 152-154 IN denotes of
T133 141-151 NN denotes regulation
T132 137-140 DT denotes the
T131 134-136 IN denotes in
T130 128-133 NNS denotes roles
T129 120-127 JJ denotes crucial
T128 114-119 VBZ denotes plays
T127 108-113 NNP denotes NF-κB
T126 101-107 NN denotes factor
T125 87-100 NN denotes transcription
T124 83-86 DT denotes The
T843 754-755 , denotes ,
T842 745-754 NNS denotes arthritis
T841 732-744 JJ denotes inflammatory
T866 884-890 NNS denotes joints
T865 881-883 IN denotes of
T864 868-880 NN denotes inflammation
T863 860-867 JJ denotes chronic
T862 854-859 WDT denotes which
T861 851-853 IN denotes in
T860 837-850 NN denotes polyarthritis
T859 825-836 JJ denotes symmetrical
T858 823-824 DT denotes a
T857 820-822 IN denotes by
T856 806-819 VBN denotes characterised
T855 803-805 VBZ denotes is
T854 800-802 NNP denotes RA
T853 798-799 . denotes .
T852 788-798 NN denotes population
T851 782-787 NN denotes adult
T850 778-781 DT denotes the
T849 775-777 IN denotes of
T848 773-774 NN denotes %
T847 772-773 CD denotes 1
T846 769-771 TO denotes to
T845 766-768 RP denotes up
T844 756-765 VBG denotes affecting
T840 725-731 JJ denotes common
T839 720-724 RBS denotes most
T838 716-719 DT denotes the
T837 713-715 VBZ denotes is
T836 711-712 -RRB- denotes )
T835 709-711 NNP denotes RA
T834 708-709 -LRB- denotes (
T930 1310-1315 VBZ denotes leads
T929 1298-1309 NNS denotes fibroblasts
T928 1289-1297 JJ denotes synovial
T927 1286-1288 IN denotes of
T926 1272-1285 NNP denotes Proliferation
T925 1270-1271 . denotes .
T924 1265-1270 NNS denotes cells
T923 1256-1264 JJ denotes synovial
T922 1252-1255 CC denotes and
T921 1242-1251 NNS denotes monocytes
T920 1229-1241 VBG denotes infiltrating
T919 1226-1228 IN denotes by
T918 1207-1225 NNS denotes metalloproteinases
T917 1200-1206 NN denotes matrix
T908 1152-1155 CC denotes and
T907 1150-1151 CD denotes 1
T906 1145-1149 NN denotes type
T905 1136-1144 NN denotes T-helper
T904 1120-1135 JJ denotes proinflammatory
T903 1117-1119 IN denotes of
T902 1106-1116 NN denotes production
T901 1100-1105 JJ denotes local
T900 1096-1099 DT denotes the
T899 1089-1095 VBZ denotes drives
T898 1083-1088 NN denotes space
T897 1077-1082 JJ denotes joint
T896 1073-1076 DT denotes the
T895 1068-1072 IN denotes into
T894 1061-1067 NN denotes system
T893 1054-1060 JJ denotes immune
T892 1045-1053 JJ denotes adaptive
T891 1041-1044 CC denotes and
T890 1034-1040 NN denotes innate
T889 1030-1033 DT denotes the
T888 1027-1029 IN denotes of
T887 1021-1026 NNS denotes cells
T886 1018-1020 IN denotes of
T885 1005-1017 NNP denotes Infiltration
T884 1003-1004 . denotes .
T916 1196-1199 CC denotes and
T915 1194-1195 , denotes ,
T914 1184-1194 NNS denotes chemokines
T913 1182-1183 , denotes ,
T912 1173-1182 NNS denotes cytokines
T911 1170-1172 CD denotes 17
T910 1165-1169 NN denotes type
T909 1156-1164 NNP denotes T-helper
T16982 30108-30109 . denotes .
T16981 30107-30108 NNP denotes ]
T18051 30305-30310 NN denotes class
T18050 30303-30304 DT denotes a
T18049 30293-30302 VB denotes represent
T18048 30289-30292 CC denotes and
T18047 30278-30288 NN denotes expression
T18046 30273-30277 NN denotes gene
T18045 30270-30272 IN denotes of
T18044 30259-30269 NNS denotes regulators
T18043 30248-30258 VBN denotes discovered
T18042 30239-30247 RB denotes recently
T18041 30235-30238 VBP denotes are
T18040 30228-30234 NNS denotes miRNAs
T18039 30218-30227 NNS denotes microRNAs
T17002 30215-30216 . denotes .
T17001 30214-30215 NNP denotes ]
T17000 30212-30214 CD denotes 76
T16999 30211-30212 NNP denotes [
T16998 30208-30210 NNP denotes RA
T16997 30203-30207 IN denotes with
T16996 30196-30202 NN denotes region
T16995 30190-30195 CD denotes TRAF1
T16994 30186-30189 DT denotes the
T16993 30183-30185 IN denotes of
T16992 30171-30182 NN denotes association
T16991 30163-30170 JJ denotes genetic
T16990 30150-30162 VBZ denotes demonstrates
T16989 30145-30149 RB denotes also
T16988 30134-30144 NN denotes population
T16987 30127-30133 JJ denotes Korean
T16986 30125-30126 DT denotes a
T16985 30122-30124 IN denotes in
T16984 30117-30121 NN denotes work
T16983 30110-30116 JJ denotes Recent
T16980 30105-30107 CD denotes 75
T16979 30104-30105 NNP denotes [
T16978 30098-30103 NN denotes locus
T16977 30088-30097 JJ denotes causative
T16976 30084-30087 DT denotes the
T18094 30569-30570 NNP denotes [
T18093 30557-30568 NN denotes degradation
T18092 30552-30556 NNP denotes mRNA
T18091 30545-30551 NN denotes target
T18090 30542-30544 IN denotes of
T18089 30532-30541 NN denotes promotion
T18088 30528-30531 DT denotes the
T18087 30524-30527 CC denotes and
T18086 30513-30523 NN denotes expression
T18085 30505-30512 NN denotes protein
T18084 30502-30504 IN denotes of
T18083 30491-30501 NN denotes repression
T18082 30487-30490 DT denotes the
T18081 30484-30486 TO denotes to
T18080 30476-30483 VBG denotes leading
T18079 30470-30475 NNS denotes mRNAs
T18078 30463-30469 NN denotes target
T18077 30460-30462 IN denotes of
T18076 30456-30459 NNP denotes UTR
T18075 30455-30456 : denotes -
T18074 30454-30455 '' denotes '
T18073 30453-30454 CD denotes 3
T18072 30449-30452 DT denotes the
T18071 30444-30448 NN denotes bind
T18070 30439-30443 PRP denotes They
T18069 30437-30438 . denotes .
T18068 30425-30437 NN denotes inflammation
T18067 30421-30424 CC denotes and
T18066 30411-30420 NNS denotes responses
T18065 30404-30410 JJ denotes immune
T18064 30394-30403 VBG denotes including
T18063 30392-30393 , denotes ,
T18062 30383-30392 NNS denotes processes
T18061 30369-30382 JJ denotes developmental
T18060 30365-30368 CC denotes and
T18059 30356-30364 JJ denotes cellular
T18058 30351-30355 JJ denotes many
T18057 30348-30350 IN denotes in
T18056 30338-30347 JJ denotes essential
T18055 30328-30337 NNS denotes molecules
T18054 30324-30327 NNP denotes RNA
T18053 30314-30323 VBG denotes noncoding
T18052 30311-30313 IN denotes of
T18233 31287-31291 IN denotes from
T18232 31281-31286 NNS denotes cells
T18231 31279-31280 NN denotes T
T18230 31263-31278 JJ denotes IL-17-producing
T18229 31259-31262 CC denotes and
T18228 31257-31258 NNP denotes +
T18227 31254-31257 NNP denotes CD4
T18226 31251-31253 IN denotes in
T18225 31237-31250 VBN denotes overexpressed
T18224 31232-31236 RB denotes also
T18223 31229-31231 VBZ denotes is
T18222 31220-31228 NN denotes miR-146a
T18221 31218-31219 . denotes .
T18220 31217-31218 NNP denotes ]
T18219 31215-31217 CD denotes 83
T18218 31214-31215 NNP denotes [
T18217 31205-31213 NNS denotes patients
T18216 31202-31204 NNP denotes RA
T18215 31199-31201 IN denotes of
T18214 31193-31198 NNS denotes cells
T18213 31181-31192 NN denotes mononuclear
T18212 31175-31180 NN denotes blood
T18211 31164-31174 JJ denotes peripheral
T18210 31161-31163 IN denotes in
T18209 31158-31160 IN denotes as
T18208 31153-31157 RB denotes well
T18207 31150-31152 RB denotes as
T18291 31632-31634 NNP denotes RA
T18290 31629-31631 IN denotes in
T18289 31617-31628 NN denotes destruction
T18288 31610-31616 NN denotes tissue
T18287 31602-31609 VBP denotes mediate
T18286 31597-31601 WDT denotes that
T18285 31578-31596 NNS denotes metalloproteinases
T18284 31571-31577 NN denotes matrix
T18283 31562-31570 JJ denotes specific
T18282 31559-31561 IN denotes of
T18281 31548-31558 NN denotes expression
T18280 31529-31547 JJ denotes cytokine-inducible
T18279 31525-31528 CC denotes and
T21924 14278-14279 , denotes ,
T21923 14270-14278 NN denotes receptor
T21922 14266-14269 DT denotes the
T21921 14263-14265 TO denotes to
T21920 14253-14262 VBN denotes recruited
T21919 14250-14252 VBZ denotes is
T21918 14244-14249 CD denotes TRAF3
T21917 14242-14243 , denotes ,
T21916 14235-14242 JJ denotes binding
T21915 14228-14234 JJ denotes ligand
T21914 14223-14227 IN denotes Upon
T21913 14221-14222 . denotes .
T21912 14218-14221 JJ denotes low
T21911 14211-14217 NNS denotes levels
T21910 14207-14210 NNP denotes NIK
T21909 14199-14206 VBG denotes keeping
T21908 14197-14198 , denotes ,
T21907 14194-14197 NNP denotes NIK
T21906 14191-14193 IN denotes of
T21905 14179-14190 NN denotes degradation
T21904 14167-14178 JJ denotes proteasomal
T21903 14163-14166 CC denotes and
T21947 14459-14460 , denotes ,
T21946 14454-14459 CD denotes TRAF3
T21945 14451-14453 TO denotes to
T21944 14432-14450 NN denotes polyubiquitination
T21943 14421-14431 JJ denotes K48-linked
T21942 14417-14420 PRP$ denotes its
T21941 14409-14416 VBZ denotes directs
T21940 14401-14408 JJ denotes cIAP1/2
T21939 14388-14400 RB denotes Subsequently
T21938 14386-14387 . denotes .
T21937 14376-14386 NN denotes activation
T21936 14370-14375 PRP$ denotes their
T21935 14367-14369 IN denotes in
T21934 14357-14366 VBG denotes resulting
T21933 14355-14356 , denotes ,
T21932 14348-14355 NNP denotes cIAP1/2
T21931 14345-14347 IN denotes of
T21930 14326-14344 NN denotes polyubiquitination
T21929 14315-14325 JJ denotes K63-linked
T21928 14300-14314 JJ denotes nondegradative
T21927 14292-14299 VBZ denotes directs
T21926 14286-14291 CD denotes TRAF2
T21925 14280-14285 WRB denotes where
R3979 T5917 T5918 compound NF-κB,proteins
R5921 T8787 T8790 mark Since,is
R7232 T10859 T10861 nummod A20,A20
R7233 T10860 T10861 compound protein,A20
R7234 T10861 T10868 nsubj A20,is
R7235 T10862 T10864 punct (,known
R100 T114 T115 amod Negative,regulation
R101 T115 T128 nsubj regulation,plays
R102 T116 T115 prep of,regulation
R103 T117 T116 pobj NF-κB,of
R104 T118 T117 cc and,NF-κB
R105 T119 T120 poss its,involvement
R106 T120 T115 appos involvement,regulation
R107 T121 T120 prep in,involvement
R108 T122 T123 amod rheumatoid,arthritis
R109 T123 T121 pobj arthritis,in
R110 T124 T126 det The,factor
R111 T125 T126 compound transcription,factor
R112 T126 T128 nsubj factor,plays
R113 T127 T128 nsubj NF-κB,plays
R114 T128 T128 ROOT plays,plays
R115 T129 T130 amod crucial,roles
R116 T130 T128 dobj roles,plays
R117 T131 T128 prep in,plays
R118 T132 T133 det the,regulation
R119 T133 T131 pobj regulation,in
R120 T134 T133 prep of,regulation
R121 T135 T138 nmod inflammation,responses
R122 T136 T135 cc and,inflammation
R123 T137 T135 conj mmune,inflammation
R124 T138 T134 pobj responses,of
R125 T139 T133 punct ",",regulation
R126 T140 T133 cc and,regulation
R127 T141 T143 amod inappropriate,activity
R128 T142 T143 compound NF-κB,activity
R129 T143 T133 conj activity,regulation
R130 T144 T146 aux has,linked
R131 T145 T146 auxpass been,linked
R132 T146 T128 conj linked,plays
R133 T147 T146 prep with,linked
R134 T148 T152 amod many,diseases
R135 T149 T152 amod autoimmune,diseases
R136 T150 T149 cc and,autoimmune
R137 T151 T149 conj inflammatory,autoimmune
R138 T152 T147 pobj diseases,with
R139 T153 T152 punct ",",diseases
R140 T154 T152 prep including,diseases
R141 T155 T156 amod rheumatoid,arthritis
R142 T156 T154 pobj arthritis,including
R143 T157 T128 punct .,plays
R144 T158 T159 nsubj Cells,employ
R145 T159 T159 ROOT employ,employ
R146 T160 T163 det a,system
R147 T161 T163 amod multilayered,system
R148 T162 T163 compound control,system
R149 T163 T159 dobj system,employ
R150 T164 T165 aux to,keep
R151 T165 T163 relcl keep,system
R152 T166 T167 amod NF-κB,signalling
R153 T167 T165 dobj signalling,keep
R154 T168 T165 prep in,keep
R155 T169 T168 pobj check,in
R156 T170 T165 punct ",",keep
R157 T171 T165 prep including,keep
R158 T172 T173 det a,repertoire
R159 T173 T171 pobj repertoire,including
R160 T174 T173 prep of,repertoire
R161 T175 T177 amod negative,regulators
R162 T176 T177 compound feedback,regulators
R163 T177 T174 pobj regulators,of
R164 T178 T173 acl ensuring,repertoire
R165 T179 T178 dobj termination,ensuring
R166 T180 T179 prep of,termination
R167 T181 T182 amod NF-κB,responses
R168 T182 T180 pobj responses,of
R169 T183 T159 punct .,employ
R170 T184 T187 advmod Here,review
R171 T185 T187 nsubj we,review
R172 T186 T187 aux will,review
R173 T187 T187 ROOT review,review
R174 T188 T191 amod various,mechanisms
R175 T189 T191 amod negative,mechanisms
R176 T190 T191 amod regulatory,mechanisms
R177 T191 T187 dobj mechanisms,review
R178 T192 T194 nsubj that,evolved
R179 T193 T194 aux have,evolved
R180 T194 T191 relcl evolved,mechanisms
R181 T195 T196 aux to,control
R182 T196 T194 xcomp control,evolved
R183 T197 T198 compound NF-κB,signalling
R184 T198 T196 dobj signalling,control
R185 T199 T194 cc and,evolved
R186 T200 T203 nsubjpass which,implicated
R187 T201 T203 aux have,implicated
R188 T202 T203 auxpass been,implicated
R189 T203 T194 conj implicated,evolved
R190 T204 T203 prep in,implicated
R191 T205 T206 det the,pathogenesis
R192 T206 T204 pobj pathogenesis,in
R193 T207 T206 prep of,pathogenesis
R194 T208 T209 amod rheumatoid,arthritis
R195 T209 T207 pobj arthritis,of
R196 T210 T187 punct .,review
R642 T832 T833 amod Rheumatoid,arthritis
R643 T833 T837 nsubj arthritis,is
R644 T834 T833 punct (,arthritis
R645 T835 T833 appos RA,arthritis
R646 T836 T833 punct ),arthritis
R647 T837 T837 ROOT is,is
R648 T838 T842 det the,arthritis
R649 T839 T840 advmod most,common
R650 T840 T842 amod common,arthritis
R651 T841 T842 amod inflammatory,arthritis
R652 T842 T837 attr arthritis,is
R653 T843 T837 punct ",",is
R654 T844 T837 advcl affecting,is
R655 T845 T847 quantmod up,1
R656 T846 T847 quantmod to,1
R657 T847 T848 nummod 1,%
R658 T848 T844 dobj %,affecting
R659 T849 T848 prep of,%
R660 T850 T852 det the,population
R661 T851 T852 compound adult,population
R662 T852 T849 pobj population,of
R663 T853 T837 punct .,is
R664 T854 T856 nsubjpass RA,characterised
R665 T855 T856 auxpass is,characterised
R666 T856 T856 ROOT characterised,characterised
R667 T857 T856 agent by,characterised
R668 T858 T860 det a,polyarthritis
R669 T859 T860 amod symmetrical,polyarthritis
R670 T860 T857 pobj polyarthritis,by
R671 T861 T868 prep in,associated
R672 T862 T861 pobj which,in
R673 T863 T864 amod chronic,inflammation
R674 T864 T868 nsubjpass inflammation,associated
R675 T865 T864 prep of,inflammation
R676 T866 T865 pobj joints,of
R677 T867 T868 auxpass is,associated
R678 T868 T860 relcl associated,polyarthritis
R679 T869 T868 prep with,associated
R680 T870 T872 det a,destruction
R681 T871 T872 amod progressive,destruction
R682 T872 T869 pobj destruction,with
R683 T873 T872 prep of,destruction
R684 T874 T873 pobj cartilage,of
R685 T875 T874 cc and,cartilage
R686 T876 T874 conj bone,cartilage
R687 T877 T872 punct ",",destruction
R688 T878 T872 acl leading,destruction
R689 T879 T878 prep to,leading
R690 T880 T881 amod functional,decline
R691 T881 T879 pobj decline,to
R692 T882 T881 cc and,decline
R693 T883 T881 conj disability,decline
R694 T884 T856 punct .,characterised
R695 T885 T899 nsubj Infiltration,drives
R696 T886 T885 prep of,Infiltration
R697 T887 T886 pobj cells,of
R698 T888 T887 prep of,cells
R699 T889 T894 det the,system
R700 T890 T894 amod innate,system
R701 T891 T890 cc and,innate
R702 T892 T890 conj adaptive,innate
R703 T893 T894 amod immune,system
R704 T894 T888 pobj system,of
R705 T895 T885 prep into,Infiltration
R706 T896 T898 det the,space
R707 T897 T898 amod joint,space
R708 T898 T899 nsubj space,drives
R709 T899 T899 ROOT drives,drives
R710 T900 T902 det the,production
R711 T901 T902 amod local,production
R712 T902 T899 dobj production,drives
R713 T903 T902 prep of,production
R714 T904 T906 amod proinflammatory,type
R715 T905 T906 compound T-helper,type
R716 T906 T903 pobj type,of
R717 T907 T906 nummod 1,type
R718 T908 T906 cc and,type
R719 T909 T910 compound T-helper,type
R720 T910 T906 conj type,type
R721 T911 T912 nummod 17,cytokines
R722 T912 T906 appos cytokines,type
R723 T913 T912 punct ",",cytokines
R724 T914 T912 conj chemokines,cytokines
R725 T915 T914 punct ",",chemokines
R726 T916 T914 cc and,chemokines
R727 T917 T918 compound matrix,metalloproteinases
R728 T918 T914 conj metalloproteinases,chemokines
R729 T919 T899 prep by,drives
R730 T920 T919 pcomp infiltrating,by
R731 T921 T920 dobj monocytes,infiltrating
R732 T922 T921 cc and,monocytes
R733 T923 T924 amod synovial,cells
R734 T924 T921 conj cells,monocytes
R735 T925 T899 punct .,drives
R736 T926 T930 nsubj Proliferation,leads
R737 T927 T926 prep of,Proliferation
R738 T928 T929 amod synovial,fibroblasts
R739 T929 T927 pobj fibroblasts,of
R740 T930 T930 ROOT leads,leads
R741 T931 T930 prep to,leads
R742 T932 T933 det the,formation
R743 T933 T931 pobj formation,to
R744 T934 T933 prep of,formation
R745 T935 T936 amod pannus,tissue
R746 T936 T934 pobj tissue,of
R747 T937 T936 punct ",",tissue
R748 T938 T939 nsubj which,invades
R749 T939 T936 relcl invades,tissue
R750 T940 T939 cc and,invades
R751 T941 T939 conj degrades,invades
R752 T942 T943 amod articular,cartilage
R753 T943 T941 dobj cartilage,degrades
R754 T944 T943 cc and,cartilage
R755 T945 T946 amod subchondral,bone
R756 T946 T943 conj bone,cartilage
R757 T947 T930 punct .,leads
R758 T948 T949 det The,aetiology
R759 T949 T952 nsubj aetiology,is
R760 T950 T949 prep of,aetiology
R761 T951 T950 pobj RA,of
R762 T952 T955 auxpass is,understood
R763 T953 T955 advmod still,understood
R764 T954 T955 neg not,understood
R765 T955 T955 ROOT understood,understood
R766 T956 T955 punct ",",understood
R767 T957 T955 cc but,understood
R768 T958 T961 nsubjpass it,accepted
R769 T959 T961 auxpass is,accepted
R770 T960 T961 advmod well,accepted
R771 T961 T955 conj accepted,understood
R772 T962 T968 mark that,plays
R773 T963 T968 nsubj activation,plays
R774 T964 T963 prep of,activation
R775 T965 T967 amod NF-κB-dependent,expression
R776 T966 T967 compound gene,expression
R777 T967 T964 pobj expression,of
R778 T968 T961 ccomp plays,accepted
R779 T969 T971 det a,role
R780 T970 T971 amod key,role
R781 T971 T968 dobj role,plays
R782 T972 T971 prep in,role
R783 T973 T974 det the,development
R784 T974 T972 pobj development,in
R785 T975 T974 prep of,development
R786 T976 T975 pobj RA,of
R787 T977 T974 cc and,development
R788 T978 T981 amod many,diseases
R789 T979 T981 amod other,diseases
R790 T980 T981 amod autoimmune,diseases
R791 T981 T974 conj diseases,development
R792 T982 T961 punct .,accepted
R793 T983 T984 nsubj NF-κB,represents
R794 T984 T984 ROOT represents,represents
R795 T985 T986 det a,family
R796 T986 T984 dobj family,represents
R797 T987 T986 prep of,family
R798 T988 T989 advmod structurally,related
R799 T989 T987 pcomp related,of
R800 T990 T984 cc and,represents
R801 T991 T992 advmod evolutionarily,conserved
R802 T992 T993 amod conserved,proteins
R803 T993 T984 conj proteins,represents
R804 T994 T993 punct (,proteins
R805 T995 T1010 nmod p100,)
R806 T996 T995 cc or,p100
R807 T997 T995 conj NF-κB2,p100
R808 T998 T997 punct ",",NF-κB2
R809 T999 T997 conj p105,NF-κB2
R810 T1000 T999 cc or,p105
R811 T1001 T999 conj NF-κB1,p105
R812 T1002 T1001 punct ",",NF-κB1
R813 T1003 T1001 conj p65,NF-κB1
R814 T1004 T1003 cc or,p65
R815 T1005 T1003 conj RelA,p65
R816 T1006 T1005 punct ",",RelA
R817 T1007 T1005 conj RelB,RelA
R818 T1008 T1007 punct ",",RelB
R819 T1009 T1007 conj c-Rel,RelB
R820 T1010 T993 punct ),proteins
R821 T1011 T1012 nsubj that,function
R822 T1012 T993 relcl function,proteins
R823 T1013 T1012 prep as,function
R824 T1014 T1013 pobj homodimers,as
R825 T1015 T1014 cc or,homodimers
R826 T1016 T1014 conj heterodimers,homodimers
R827 T1017 T1019 nmod [,]
R828 T1018 T1019 nummod 1,]
R829 T1019 T993 conj ],proteins
R830 T1020 T1019 punct ",",]
R831 T1021 T984 cc and,represents
R832 T1022 T1023 mark that,regulate
R833 T1023 T984 conj regulate,represents
R834 T1024 T1025 det the,expression
R835 T1025 T1023 dobj expression,regulate
R836 T1026 T1025 prep of,expression
R837 T1027 T1029 det a,number
R838 T1028 T1029 amod large,number
R839 T1029 T1026 pobj number,of
R840 T1030 T1029 prep of,number
R841 T1031 T1030 pobj genes,of
R842 T1032 T1031 punct -,genes
R843 T1033 T1034 amod such,as
R844 T1034 T1031 prep as,genes
R845 T1035 T1034 pobj TNF,as
R846 T1036 T1035 punct ",",TNF
R847 T1037 T1035 conj IL-1,TNF
R848 T1038 T1037 punct ",",IL-1
R849 T1039 T1037 conj IL-6,IL-1
R850 T1040 T1039 punct ",",IL-6
R851 T1041 T1039 conj cyclo-oxygenase-2,IL-6
R852 T1042 T1041 punct ",",cyclo-oxygenase-2
R853 T1043 T1041 conj chemokines,cyclo-oxygenase-2
R854 T1044 T1043 punct ",",chemokines
R855 T1045 T1048 amod inducible,synthase
R856 T1046 T1047 amod nitric,oxide
R857 T1047 T1048 compound oxide,synthase
R858 T1048 T1043 conj synthase,chemokines
R859 T1049 T1048 punct ",",synthase
R860 T1050 T1048 cc and,synthase
R861 T1051 T1052 compound matrix,metalloproteinases
R862 T1052 T1048 conj metalloproteinases,synthase
R863 T1053 T1056 punct -,involved
R864 T1054 T1056 nsubjpass that,involved
R865 T1055 T1056 auxpass are,involved
R866 T1056 T1025 relcl involved,expression
R867 T1057 T1056 prep in,involved
R868 T1058 T1057 pobj RA,in
R869 T1059 T984 punct .,represents
R870 T1060 T1066 prep In,are
R871 T1061 T1060 pobj addition,In
R872 T1062 T1066 punct ",",are
R873 T1063 T1066 nsubj TNF,are
R874 T1064 T1063 cc and,TNF
R875 T1065 T1063 conj IL-1,TNF
R876 T1066 T1066 ROOT are,are
R877 T1067 T1066 nsubj themselves,are
R878 T1068 T1069 advmod very,potent
R879 T1069 T1070 amod potent,activators
R880 T1070 T1066 attr activators,are
R881 T1071 T1070 prep of,activators
R882 T1072 T1071 pobj NF-κB,of
R883 T1073 T1072 punct (,NF-κB
R884 T1074 T1072 acl reviewed,NF-κB
R885 T1075 T1074 prep in,reviewed
R886 T1076 T1075 pobj [,in
R887 T1077 T1078 nummod "2,3",]
R888 T1078 T1076 appos ],[
R889 T1079 T1076 punct ),[
R890 T1080 T1066 punct .,are
R891 T1081 T1082 amod NF-κB,activation
R892 T1082 T1085 nsubjpass activation,detected
R893 T1083 T1085 aux can,detected
R894 T1084 T1085 auxpass be,detected
R895 T1085 T1104 ccomp detected,demonstrate
R896 T1086 T1085 prep in,detected
R897 T1087 T1089 amod cultured,fibroblasts
R898 T1088 T1089 amod synovial,fibroblasts
R899 T1089 T1086 pobj fibroblasts,in
R900 T1090 T1089 cc and,fibroblasts
R901 T1091 T1092 amod synovial,tissue
R902 T1092 T1089 conj tissue,fibroblasts
R903 T1093 T1092 prep from,tissue
R904 T1094 T1095 compound RA,patients
R905 T1095 T1093 pobj patients,from
R906 T1096 T1092 punct ",",tissue
R907 T1097 T1092 cc and,tissue
R908 T1098 T1099 compound animal,models
R909 T1099 T1104 nsubj models,demonstrate
R910 T1100 T1099 prep of,models
R911 T1101 T1102 amod inflammatory,arthritis
R912 T1102 T1100 pobj arthritis,of
R913 T1103 T1104 advmod also,demonstrate
R914 T1104 T1104 ROOT demonstrate,demonstrate
R915 T1105 T1107 det the,role
R916 T1106 T1107 amod active,role
R917 T1107 T1104 dobj role,demonstrate
R918 T1108 T1107 prep of,role
R919 T1109 T1108 pobj NF-κB,of
R920 T1110 T1107 prep in,role
R921 T1111 T1112 det the,development
R922 T1112 T1110 pobj development,in
R923 T1113 T1112 cc and,development
R924 T1114 T1112 conj progression,development
R925 T1115 T1112 prep of,development
R926 T1116 T1115 pobj RA,of
R927 T1117 T1107 punct (,role
R928 T1118 T1107 acl reviewed,role
R929 T1119 T1118 prep in,reviewed
R930 T1120 T1119 pobj [,in
R931 T1121 T1122 nummod 4,]
R932 T1122 T1120 appos ],[
R933 T1123 T1120 punct ),[
R934 T1124 T1104 punct .,demonstrate
R935 T1125 T1127 det The,course
R936 T1126 T1127 compound time,course
R937 T1127 T1131 nsubj course,appears
R938 T1128 T1127 prep of,course
R939 T1129 T1130 amod NF-κB,activation
R940 T1130 T1128 pobj activation,of
R941 T1131 T1131 ROOT appears,appears
R942 T1132 T1133 aux to,precede
R943 T1133 T1131 xcomp precede,appears
R944 T1134 T1135 det the,onset
R945 T1135 T1133 dobj onset,precede
R946 T1136 T1135 prep of,onset
R947 T1137 T1136 pobj disease,of
R948 T1138 T1135 punct ",",onset
R949 T1139 T1135 cc and,onset
R950 T1140 T1135 conj blockade,onset
R951 T1141 T1135 prep of,onset
R952 T1142 T1141 pobj NF-κB,of
R953 T1143 T1133 prep by,precede
R954 T1144 T1145 amod different,means
R955 T1145 T1143 pobj means,by
R956 T1146 T1131 conj decreases,appears
R957 T1147 T1148 compound disease,severity
R958 T1148 T1146 dobj severity,decreases
R959 T1149 T1151 compound [,]
R960 T1150 T1151 compound "5,6",]
R961 T1151 T1151 ROOT ],]
R962 T1152 T1131 punct .,appears
R963 T1153 T1163 advmod Next,is
R964 T1154 T1153 prep to,Next
R965 T1155 T1156 poss its,role
R966 T1156 T1154 pobj role,to
R967 T1157 T1156 prep in,role
R968 T1158 T1160 amod proinflammatory,expression
R969 T1159 T1160 compound gene,expression
R970 T1160 T1157 pobj expression,in
R971 T1161 T1163 punct ",",is
R972 T1162 T1163 nsubj NF-κB,is
R973 T1163 T1163 ROOT is,is
R974 T1164 T1163 advmod also,is
R975 T1165 T1163 acomp essential,is
R976 T1166 T1165 prep for,essential
R977 T1167 T1166 pobj osteoclastogenesis,for
R978 T1168 T1166 punct ",",for
R979 T1169 T1170 advmod mainly,by
R980 T1170 T1163 prep by,is
R981 T1171 T1170 pcomp mediating,by
R982 T1172 T1173 det the,effects
R983 T1173 T1171 dobj effects,mediating
R984 T1174 T1173 prep of,effects
R985 T1175 T1176 compound receptor,activator
R986 T1176 T1174 pobj activator,of
R987 T1177 T1176 prep of,activator
R988 T1178 T1179 amod NF-κB,ligand
R989 T1179 T1177 pobj ligand,of
R990 T1180 T1181 punct (,RANKL
R991 T1222 T1221 punct ",",signalling
R992 T1181 T1179 appos RANKL,ligand
R993 T1223 T1221 prep including,signalling
R994 T1224 T1223 pobj CD40,including
R995 T1182 T1163 punct ),is
R996 T1183 T1163 punct .,is
R997 T1225 T1224 punct ",",CD40
R998 T1184 T1190 nsubj Defects,are
R999 T1226 T1224 appos TRAF1,CD40
R1000 T1185 T1184 prep in,Defects
R1001 T1227 T1224 punct ",",CD40
R1002 T1228 T1224 appos TNFAIP3,CD40
R1003 T1229 T1224 punct ",",CD40
R1004 T1186 T1187 det the,regulation
R1005 T1230 T1224 cc and,CD40
R1006 T1231 T1224 conj c-REL,CD40
R1007 T1232 T1231 punct ",",c-REL
R1008 T1187 T1185 pobj regulation,in
R1009 T1233 T1234 advmod further,highlight
R1010 T1234 T1221 appos highlight,signalling
R1011 T1188 T1187 prep of,regulation
R1012 T1235 T1236 det the,importance
R1013 T1236 T1234 dobj importance,highlight
R1014 T1237 T1236 prep of,importance
R1015 T1238 T1239 amod NF-κB,activation
R1016 T1239 T1237 pobj activation,of
R1017 T1240 T1239 prep in,activation
R1018 T1189 T1188 pobj osteoclastogenesis,of
R1019 T1241 T1243 nmod RA,[
R1020 T1242 T1243 compound pathogenesis,[
R1021 T1243 T1240 pobj [,in
R1022 T1190 T1190 ROOT are,are
R1023 T1244 T1245 nummod 8,]
R1024 T1245 T1243 appos ],[
R1025 T1246 T1207 punct .,Finally
R1026 T1191 T1193 det the,cause
R1027 T1192 T1193 amod major,cause
R1028 T1193 T1190 attr cause,are
R1029 T1194 T1193 prep of,cause
R1030 T1195 T1196 compound bone,erosion
R1031 T1196 T1194 pobj erosion,of
R1032 T1197 T1196 prep in,erosion
R1033 T1198 T1199 amod osteolytic,diseases
R1034 T1199 T1197 pobj diseases,in
R1035 T1200 T1201 amod such,as
R1036 T1201 T1199 prep as,diseases
R1037 T1202 T1203 compound RA,[
R1038 T1203 T1201 pobj [,as
R1039 T1204 T1205 nummod 7,]
R1040 T1205 T1203 conj ],[
R1041 T1206 T1190 punct .,are
R1042 T1207 T1207 ROOT Finally,Finally
R1043 T1208 T1210 punct ",",discoveries
R1044 T1209 T1210 amod recent,discoveries
R1045 T1210 T1207 pobj discoveries,Finally
R1046 T1211 T1210 acl revealing,discoveries
R1047 T1212 T1214 det a,association
R1048 T1213 T1214 amod genetic,association
R1049 T1214 T1211 dobj association,revealing
R1050 T1215 T1214 prep with,association
R1051 T1216 T1217 amod several,genes
R1052 T1217 T1215 pobj genes,with
R1053 T1218 T1217 amod relevant,genes
R1054 T1219 T1218 prep to,relevant
R1055 T1220 T1221 amod NF-κB,signalling
R1056 T1221 T1219 pobj signalling,to
R1987 T2608 T2610 mark Since,is
R1988 T2609 T2610 nsubj NF-κB,is
R1989 T2610 T2622 advcl is,deals
R1990 T2611 T2610 acomp central,is
R1991 T2612 T2611 prep to,central
R1992 T2613 T2614 det the,process
R1993 T2614 T2612 pobj process,to
R1994 T2615 T2614 prep of,process
R1995 T2616 T2615 pobj inflammation,of
R1996 T2617 T2614 prep in,process
R1997 T2618 T2617 pobj RA,in
R1998 T2619 T2622 punct ",",deals
R1999 T2620 T2622 amod much,deals
R2000 T2621 T2622 compound research,deals
R2001 T2622 T2622 ROOT deals,deals
R2002 T2623 T2622 prep with,deals
R2003 T2624 T2625 det the,identification
R2004 T2625 T2623 pobj identification,with
R2005 T2626 T2625 prep of,identification
R2006 T2627 T2628 det the,molecular
R2007 T2628 T2626 pobj molecular,of
R2008 T2629 T2622 conj triggers,deals
R2009 T2630 T2631 nsubj that,activate
R2010 T2631 T2629 ccomp activate,triggers
R2011 T2632 T2631 dobj NF-κB,activate
R2012 T2633 T2631 prep in,activate
R2013 T2634 T2633 pobj RA,in
R2014 T2635 T2629 punct .,triggers
R2015 T2636 T2639 nsubjpass It,accepted
R2016 T2637 T2639 auxpass is,accepted
R2017 T2638 T2639 advmod well,accepted
R2018 T2639 T2639 ROOT accepted,accepted
R2019 T2640 T2648 mark that,play
R2020 T2641 T2642 amod proinflammatory,cytokines
R2021 T2642 T2648 nsubj cytokines,play
R2022 T2643 T2644 amod such,as
R2023 T2644 T2642 prep as,cytokines
R2024 T2645 T2644 pobj TNF,as
R2025 T2646 T2645 cc and,TNF
R2026 T2647 T2645 conj IL-1,TNF
R2027 T2648 T2639 ccomp play,accepted
R2028 T2649 T2651 det an,role
R2029 T2650 T2651 amod important,role
R2030 T2651 T2648 dobj role,play
R2031 T2652 T2648 punct ",",play
R2032 T2653 T2648 cc and,play
R2033 T2654 T2648 conj administration,play
R2034 T2655 T2654 prep of,administration
R2035 T2656 T2657 compound TNF,antagonists
R2036 T2657 T2655 pobj antagonists,of
R2037 T2658 T2639 conj is,accepted
R2038 T2659 T2661 det an,treatment
R2039 T2660 T2661 amod effective,treatment
R2040 T2661 T2658 attr treatment,is
R2041 T2662 T2661 prep for,treatment
R2042 T2663 T2664 amod severe,RA
R2043 T2664 T2662 pobj RA,for
R2044 T2665 T2666 punct (,reviewed
R2045 T2666 T2664 parataxis reviewed,RA
R2046 T2667 T2666 prep in,reviewed
R2047 T2668 T2667 pobj [,in
R2048 T2669 T2670 nummod 9,]
R2049 T2670 T2668 appos ],[
R2050 T2671 T2668 punct ),[
R2051 T2672 T2639 punct .,accepted
R2052 T2673 T2676 nsubj TNF,are
R2053 T2674 T2673 cc and,TNF
R2054 T2675 T2673 conj IL-1,TNF
R2055 T2676 T2676 ROOT are,are
R2056 T2677 T2676 dep both,are
R2057 T2678 T2679 advmod very,potent
R2058 T2679 T2680 amod potent,activators
R2059 T2680 T2676 attr activators,are
R2060 T2681 T2680 prep of,activators
R2061 T2682 T2681 pobj NF-κB,of
R2062 T2683 T2676 cc and,are
R2063 T2684 T2687 nsubjpass it,expected
R2064 T2685 T2687 aux can,expected
R2065 T2686 T2687 auxpass be,expected
R2066 T2687 T2676 conj expected,are
R2067 T2688 T2690 det that,activation
R2068 T2689 T2690 amod NF-κB,activation
R2069 T2690 T2694 nsubj activation,mediates
R2070 T2691 T2690 prep by,activation
R2071 T2692 T2693 det these,cytokines
R2072 T2693 T2691 pobj cytokines,by
R2073 T2694 T2676 conj mediates,are
R2074 T2695 T2694 dobj most,mediates
R2075 T2696 T2695 prep of,most
R2076 T2697 T2699 poss their,activities
R2077 T2698 T2699 amod pro-inflammatory,activities
R2078 T2699 T2696 pobj activities,of
R2079 T2700 T2699 prep in,activities
R2080 T2701 T2700 pobj RA,in
R2081 T2702 T2701 punct (,RA
R2082 T2703 T2694 advcl reviewed,mediates
R2083 T2704 T2703 prep in,reviewed
R2084 T2705 T2704 pobj [,in
R2085 T2706 T2707 nummod 3,]
R2086 T2707 T2705 appos ],[
R2087 T2708 T2705 punct ),[
R2088 T2709 T2694 punct .,mediates
R2089 T2710 T2711 amod NF-κB,activation
R2090 T2711 T2727 nsubj activation,is
R2091 T2712 T2711 prep by,activation
R2092 T2713 T2712 pobj receptor,by
R2093 T2714 T2711 conj activator,activation
R2094 T2715 T2711 prep of,activation
R2095 T2716 T2715 pobj NF-κB,of
R2096 T2717 T2716 punct (,NF-κB
R2097 T2718 T2716 appos RANK,NF-κB
R2098 T2719 T2716 punct ),NF-κB
R2099 T2720 T2716 punct ",",NF-κB
R2100 T2721 T2725 det a,member
R2101 T2722 T2725 compound TNF,member
R2102 T2723 T2725 compound receptor,member
R2103 T2724 T2725 compound family,member
R2104 T2725 T2716 appos member,NF-κB
R2105 T2726 T2727 punct ",",is
R2106 T2727 T2727 ROOT is,is
R2107 T2728 T2727 acomp important,is
R2108 T2729 T2728 prep for,important
R2109 T2730 T2729 pobj osteoclastogenesis,for
R2110 T2731 T2729 punct ",",for
R2111 T2732 T2728 cc and,important
R2112 T2733 T2728 conj defects,important
R2113 T2734 T2727 prep in,is
R2114 T2735 T2736 amod proper,RANK-NF-κB
R2115 T2736 T2734 pobj RANK-NF-κB,in
R2116 T2737 T2738 nsubj signalling,are
R2117 T2738 T2727 conj are,is
R2118 T2739 T2738 acomp likely,are
R2119 T2740 T2742 aux to,involved
R2120 T2741 T2742 auxpass be,involved
R2121 T2742 T2739 xcomp involved,likely
R2122 T2743 T2742 prep in,involved
R2123 T2744 T2745 compound RA,pathology
R2124 T2745 T2743 pobj pathology,in
R2125 T2746 T2745 cc and,pathology
R2126 T2747 T2748 amod other,diseases
R2127 T2748 T2745 conj diseases,pathology
R2128 T2749 T2748 acl associated,diseases
R2129 T2750 T2749 prep with,associated
R2130 T2751 T2752 compound bone,loss
R2131 T2752 T2753 compound loss,[
R2132 T2753 T2755 compound [,]
R2133 T2754 T2755 nummod 7,]
R2134 T2755 T2750 pobj ],with
R2135 T2756 T2738 punct .,are
R2136 T2757 T2758 nsubj CD40,is
R2137 T2758 T2758 ROOT is,is
R2138 T2759 T2763 det another,member
R2139 T2760 T2763 compound TNF,member
R2140 T2761 T2763 compound receptor,member
R2141 T2762 T2763 compound family,member
R2142 T2763 T2758 attr member,is
R2143 T2764 T2767 nsubjpass that,expressed
R2144 T2765 T2767 auxpass is,expressed
R2145 T2766 T2767 advmod functionally,expressed
R2146 T2767 T2763 relcl expressed,member
R2147 T2768 T2767 prep on,expressed
R2148 T2769 T2770 det a,variety
R2149 T2770 T2768 pobj variety,on
R2150 T2771 T2770 prep of,variety
R2151 T2772 T2773 compound cell,types
R2152 T2773 T2771 pobj types,of
R2153 T2774 T2770 punct ",",variety
R2154 T2775 T2770 prep including,variety
R2155 T2776 T2777 amod smooth,muscle
R2156 T2777 T2778 compound muscle,fibroblasts
R2157 T2778 T2775 pobj fibroblasts,including
R2158 T2779 T2778 prep from,fibroblasts
R2159 T2780 T2783 amod normal,patients
R2160 T2781 T2780 cc and,normal
R2161 T2782 T2783 compound RA,patients
R2162 T2783 T2779 pobj patients,from
R2163 T2784 T2778 cc and,fibroblasts
R2164 T2785 T2787 nmod RA,cells
R2165 T2786 T2787 amod synovial,cells
R2166 T2787 T2778 conj cells,fibroblasts
R2167 T2788 T2787 punct ",",cells
R2168 T2789 T2790 compound B,cells
R2169 T2790 T2787 conj cells,cells
R2170 T2791 T2790 punct ",",cells
R2171 T2792 T2790 conj macrophages,cells
R2172 T2793 T2792 punct ",",macrophages
R2173 T2794 T2792 cc and,macrophages
R2174 T2795 T2796 amod dendritic,cells
R2175 T2796 T2792 conj cells,macrophages
R2176 T2797 T2758 punct ",",is
R2177 T2798 T2758 cc and,is
R2178 T2799 T2801 aux can,upregulated
R2179 T2800 T2801 auxpass be,upregulated
R2180 T2801 T2758 conj upregulated,is
R2181 T2802 T2801 agent by,upregulated
R2182 T2803 T2804 amod proinflammatory,cytokines
R2183 T2804 T2802 pobj cytokines,by
R2184 T2805 T2804 prep including,cytokines
R2185 T2806 T2807 compound TNF,[
R2186 T2807 T2805 pobj [,including
R2187 T2808 T2809 nummod 10,]
R2188 T2809 T2807 appos ],[
R2189 T2810 T2758 punct .,is
R2190 T2811 T2834 advcl Binding,triggers
R2191 T2812 T2811 prep of,Binding
R2192 T2813 T2815 det the,ligand
R2193 T2814 T2815 compound CD40,ligand
R2194 T2815 T2812 pobj ligand,of
R2195 T2816 T2817 punct (,CD154
R2196 T2817 T2815 appos CD154,ligand
R2197 T2818 T2817 punct ),CD154
R2198 T2819 T2815 punct ",",ligand
R2199 T2820 T2823 nsubjpass which,expressed
R2200 T2821 T2823 auxpass is,expressed
R2201 T2822 T2823 advmod transiently,expressed
R2202 T2823 T2815 relcl expressed,ligand
R2203 T2824 T2823 prep on,expressed
R2204 T2825 T2826 det the,surface
R2205 T2826 T2824 pobj surface,on
R2206 T2827 T2826 prep of,surface
R2207 T2828 T2832 amod activated,cells
R2208 T2829 T2832 compound CD4,cells
R2209 T2830 T2832 nummod +,cells
R2210 T2831 T2832 compound T,cells
R2211 T2832 T2827 pobj cells,of
R2212 T2833 T2834 punct ",",triggers
R2213 T2834 T2834 ROOT triggers,triggers
R2214 T2835 T2836 compound NF-κB,activation
R2215 T2836 T2834 dobj activation,triggers
R2216 T2837 T2836 acl resulting,activation
R2217 T2838 T2837 prep in,resulting
R2218 T2839 T2840 compound fibroblast,proliferation
R2219 T2840 T2838 pobj proliferation,in
R2220 T2841 T2840 cc and,proliferation
R2221 T2842 T2840 conj secretion,proliferation
R2222 T2843 T2842 prep of,secretion
R2223 T2844 T2845 amod proinflammatory,cytokines
R2224 T2845 T2843 pobj cytokines,of
R2225 T2846 T2845 cc and,cytokines
R2226 T2847 T2845 conj chemokines,cytokines
R2227 T2848 T2845 punct ",",cytokines
R2228 T2849 T2850 nsubj which,contributes
R2229 T2850 T2840 relcl contributes,proliferation
R2230 T2851 T2850 prep to,contributes
R2231 T2852 T2853 amod joint,destruction
R2232 T2853 T2851 pobj destruction,to
R2233 T2854 T2834 punct .,triggers
R2234 T2855 T2864 advmod However,led
R2235 T2856 T2864 punct ",",led
R2236 T2857 T2864 nsubj studies,led
R2237 T2858 T2857 prep with,studies
R2238 T2859 T2863 amod antagonistic,antibodies
R2239 T2860 T2863 amod anti-CD40,antibodies
R2240 T2861 T2860 cc or,anti-CD40
R2241 T2862 T2860 conj anti-CD154,anti-CD40
R2242 T2863 T2858 pobj antibodies,with
R2243 T2923 T2918 pobj lymphocytes,of
R2244 T2864 T2864 ROOT led,led
R2245 T2924 T2925 punct ",",is
R2246 T2865 T2864 prep to,led
R2247 T2925 T2925 ROOT is,is
R2248 T2926 T2925 advmod also,is
R2249 T2866 T2867 det the,conclusion
R2250 T2927 T2925 acomp characteristic,is
R2251 T2928 T2927 prep for,characteristic
R2252 T2929 T2928 pobj RA,for
R2253 T2867 T2865 pobj conclusion,to
R2254 T2930 T2925 punct ",",is
R2255 T2931 T2925 cc and,is
R2256 T2932 T2937 nsubjpass antagonists,developed
R2257 T2868 T2872 mark that,be
R2258 T2933 T2932 prep of,antagonists
R2259 T2934 T2933 pobj BAFF,of
R2260 T2935 T2937 aux have,developed
R2261 T2869 T2870 compound CD40,signals
R2262 T2936 T2937 auxpass been,developed
R2263 T2937 T2925 conj developed,is
R2264 T2938 T2939 aux to,counter
R2265 T2870 T2872 nsubj signals,be
R2266 T2939 T2937 advcl counter,developed
R2267 T2940 T2941 compound RA,[
R2268 T2941 T2939 dobj [,counter
R2269 T2871 T2872 aux may,be
R2270 T2942 T2943 nummod 13,]
R2271 T2943 T2941 appos ],[
R2272 T2944 T2925 punct .,is
R2273 T2872 T2867 acl be,conclusion
R2274 T2945 T2953 advmod Finally,implicated
R2275 T2946 T2953 punct ",",implicated
R2276 T2947 T2950 amod lymphotoxin,signalling
R2277 T2948 T2949 compound β,receptor
R2278 T2949 T2950 compound receptor,signalling
R2279 T2873 T2872 acomp important,be
R2280 T2950 T2953 nsubjpass signalling,implicated
R2281 T2951 T2953 aux has,implicated
R2282 T2874 T2872 prep at,be
R2283 T2952 T2953 auxpass been,implicated
R2284 T2953 T2953 ROOT implicated,implicated
R2285 T2954 T2953 prep in,implicated
R2286 T2955 T2958 amod tertiary,formation
R2287 T2875 T2877 det the,stages
R2288 T2876 T2877 amod initial,stages
R2289 T2956 T2958 amod lymphoid,formation
R2290 T2877 T2874 pobj stages,at
R2291 T2957 T2958 compound organ,formation
R2292 T2958 T2954 pobj formation,in
R2293 T2959 T2958 prep at,formation
R2294 T2878 T2877 prep of,stages
R2295 T2960 T2959 pobj sites,at
R2296 T2961 T2960 prep of,sites
R2297 T2962 T2963 amod chronic,inflammation
R2298 T2879 T2880 compound arthritis,induction
R2299 T2963 T2961 pobj inflammation,of
R2300 T2964 T2960 prep including,sites
R2301 T2965 T2966 compound RA,[
R2302 T2880 T2878 pobj induction,of
R2303 T2966 T2964 pobj [,including
R2304 T2967 T2968 nummod 13,]
R2305 T2968 T2966 appos ],[
R2306 T2881 T2864 punct ",",led
R2307 T2969 T2953 punct .,implicated
R2308 T2970 T2971 amod Toll-like,receptors
R2309 T2882 T2864 cc but,led
R2310 T2971 T2977 nsubjpass receptors,implicated
R2311 T2972 T2971 punct (,receptors
R2312 T2973 T2971 appos TLRs,receptors
R2313 T2974 T2971 punct ),receptors
R2314 T2883 T2885 auxpass are,required
R2315 T2975 T2977 aux have,implicated
R2316 T2976 T2977 auxpass been,implicated
R2317 T2977 T2977 ROOT implicated,implicated
R2318 T2884 T2885 neg not,required
R2319 T2978 T2977 prep in,implicated
R2320 T2979 T2980 det a,variety
R2321 T2885 T2864 conj required,led
R2322 T2980 T2978 pobj variety,in
R2323 T2981 T2980 prep of,variety
R2324 T2982 T2983 amod autoimmune,diseases
R2325 T2983 T2981 pobj diseases,of
R2326 T2984 T2977 cc and,implicated
R2327 T2985 T2977 conj are,implicated
R2328 T2886 T2889 mark once,established
R2329 T2986 T2987 amod potential,candidates
R2330 T2987 T2985 attr candidates,are
R2331 T2988 T2987 prep for,candidates
R2332 T2989 T2988 pcomp inducing,for
R2333 T2887 T2889 nsubjpass disease,established
R2334 T2990 T2991 amod NF-κB-dependent,inflammation
R2335 T2991 T2989 dobj inflammation,inducing
R2336 T2888 T2889 auxpass is,established
R2337 T2992 T2991 prep in,inflammation
R2338 T2993 T2992 pobj RA,in
R2339 T2994 T2977 punct .,implicated
R2340 T2995 T3021 prep In,reported
R2341 T2889 T2885 advcl established,required
R2342 T2996 T2995 pobj addition,In
R2343 T2997 T2996 prep to,addition
R2344 T2998 T2999 amod microbial,ligands
R2345 T2890 T2889 cc and,established
R2346 T2999 T2997 pobj ligands,to
R2347 T3000 T2999 punct ",",ligands
R2348 T2891 T2889 conj pathogenic,established
R2349 T3001 T3003 det an,number
R2350 T3002 T3003 amod increasing,number
R2351 T3003 T2999 appos number,ligands
R2352 T2892 T2893 nsubj antibodies,are
R2353 T3004 T3003 prep of,number
R2354 T3005 T3006 amod endogenous,ligands
R2355 T3006 T3004 pobj ligands,of
R2356 T2893 T2864 conj are,led
R2357 T3007 T3006 punct -,ligands
R2358 T3008 T3009 det a,group
R2359 T3009 T3003 conj group,number
R2360 T2894 T2893 advmod already,are
R2361 T3010 T3009 prep of,group
R2362 T3011 T3010 pobj proteins,of
R2363 T3012 T3011 acl derived,proteins
R2364 T2895 T2893 acomp present,are
R2365 T3013 T3012 prep from,derived
R2366 T3014 T3015 compound host,tissues
R2367 T3015 T3013 pobj tissues,from
R2368 T2896 T2898 compound [,]
R2369 T3016 T3015 cc and,tissues
R2370 T3017 T3015 conj cells,tissues
R2371 T3018 T3021 punct -,reported
R2372 T2897 T2898 compound "11,12",]
R2373 T3019 T3021 aux have,reported
R2374 T2898 T2893 attr ],are
R2375 T2899 T2893 punct .,are
R2376 T3020 T3021 auxpass been,reported
R2377 T3021 T3021 ROOT reported,reported
R2378 T3022 T3021 prep as,reported
R2379 T3023 T3024 compound candidate,activators
R2380 T2900 T2901 amod Enhanced,expression
R2381 T3024 T3022 pobj activators,as
R2382 T3025 T3024 prep of,activators
R2383 T3026 T3025 pobj TLRs,of
R2384 T3027 T3024 acl inducing,activators
R2385 T2901 T2925 nsubj expression,is
R2386 T3028 T3030 amod so-called,inflammation
R2387 T2902 T2901 prep of,expression
R2388 T3029 T3030 amod sterile,inflammation
R2389 T3030 T3027 dobj inflammation,inducing
R2390 T3031 T3030 punct (,inflammation
R2391 T2903 T2907 det the,member
R2392 T3032 T3030 acl reviewed,inflammation
R2393 T2904 T2907 compound TNF,member
R2394 T3033 T3032 prep in,reviewed
R2395 T2905 T2907 compound receptor,member
R2396 T3034 T3033 pobj [,in
R2397 T3035 T3036 nummod "14,15",]
R2398 T2906 T2907 compound family,member
R2399 T3036 T3034 appos ],[
R2400 T2907 T2910 nmod member,factor
R2401 T3037 T3034 punct ),[
R2402 T2908 T2910 nmod B-cell,factor
R2403 T3038 T3021 punct .,reported
R2404 T3039 T3041 nsubjpass TLRs,expressed
R2405 T3040 T3041 auxpass are,expressed
R2406 T2909 T2910 amod activating,factor
R2407 T3041 T3041 ROOT expressed,expressed
R2408 T3042 T3041 prep in,expressed
R2409 T3043 T3045 compound RA,tissues
R2410 T2910 T2902 pobj factor,of
R2411 T3044 T3045 compound synovial,tissues
R2412 T3045 T3042 pobj tissues,in
R2413 T2911 T2912 punct (,BAFF
R2414 T3046 T3045 cc and,tissues
R2415 T3047 T3049 amod various,ligands
R2416 T3048 T3049 amod endogenous,ligands
R2417 T2912 T2910 appos BAFF,factor
R2418 T3049 T3045 conj ligands,tissues
R2419 T3050 T3041 conj are,expressed
R2420 T2913 T2910 punct ),factor
R2421 T3051 T3050 acomp present,are
R2422 T3052 T3050 prep within,are
R2423 T3053 T3055 det the,joints
R2424 T3054 T3055 amod inflamed,joints
R2425 T2914 T2901 punct ",",expression
R2426 T3055 T3052 pobj joints,within
R2427 T3056 T3055 prep of,joints
R2428 T3057 T3058 compound RA,patients
R2429 T3058 T3056 pobj patients,of
R2430 T3059 T3041 punct .,expressed
R2431 T3060 T3075 advmod Moreover,identify
R2432 T2915 T2901 acl allowing,expression
R2433 T3061 T3075 punct ",",identify
R2434 T3062 T3063 compound animal,models
R2435 T3063 T3075 nsubj models,identify
R2436 T2916 T2917 det the,survival
R2437 T3064 T3063 acl using,models
R2438 T3065 T3067 compound TLR,mice
R2439 T3066 T3067 compound knockout,mice
R2440 T2917 T2915 dobj survival,allowing
R2441 T3067 T3064 dobj mice,using
R2442 T3068 T3067 cc or,mice
R2443 T3069 T3067 conj strategies,mice
R2444 T2918 T2917 prep of,survival
R2445 T3070 T3071 aux to,block
R2446 T3071 T3064 xcomp block,using
R2447 T3072 T3071 dobj TLR,block
R2448 T3073 T3064 conj signalling,using
R2449 T2919 T2921 npadvmod autoantibody,producing
R2450 T3074 T3075 advmod clearly,identify
R2451 T3075 T3075 ROOT identify,identify
R2452 T3076 T3077 amod TLR-dependent,inflammation
R2453 T2920 T2921 punct -,producing
R2454 T3077 T3075 dobj inflammation,identify
R2455 T3078 T3075 prep as,identify
R2456 T3079 T3078 pcomp being,as
R2457 T2921 T2923 amod producing,lymphocytes
R2458 T3080 T3079 acomp important,being
R2459 T3081 T3079 prep in,being
R2460 T3082 T3083 det the,pathogenesis
R2461 T2922 T2923 compound B,lymphocytes
R2462 T3083 T3081 pobj pathogenesis,in
R2463 T3084 T3083 prep of,pathogenesis
R2464 T3085 T3086 det the,disease
R2465 T3117 T3093 punct ",",protein
R2466 T3086 T3084 pobj disease,of
R2467 T3087 T3075 punct .,identify
R2468 T3088 T3091 amod High,box
R2469 T3118 T3118 ROOT is,is
R2470 T3089 T3091 compound mobility,box
R2471 T3090 T3091 compound group,box
R2472 T3091 T3093 compound box,protein
R2473 T3092 T3093 compound chromosomal,protein
R2474 T3119 T3118 attr one,is
R2475 T3093 T3118 nsubj protein,is
R2476 T3094 T3093 nummod 1,protein
R2477 T3095 T3093 punct (,protein
R2478 T3096 T3093 appos HMGB1,protein
R2479 T3097 T3093 punct ),protein
R2480 T3098 T3093 punct ",",protein
R2481 T3120 T3119 prep of,one
R2482 T3099 T3103 det a,component
R2483 T3100 T3101 advmod highly,conserved
R2484 T3101 T3103 amod conserved,component
R2485 T3102 T3103 compound chromatin,component
R2486 T3121 T3126 det the,ligands
R2487 T3103 T3093 appos component,protein
R2488 T3104 T3108 nsubjpass that,secreted
R2489 T3122 T3123 advmod most,putative
R2490 T3105 T3108 aux can,secreted
R2491 T3106 T3108 auxpass be,secreted
R2492 T3107 T3108 advmod actively,secreted
R2493 T3123 T3126 amod putative,ligands
R2494 T3108 T3103 relcl secreted,component
R2495 T3109 T3108 agent by,secreted
R2496 T3110 T3109 pobj macrophages,by
R2497 T3124 T3126 amod endogenous,ligands
R2498 T3111 T3110 cc or,macrophages
R2499 T3112 T3113 advmod passively,released
R2500 T3113 T3110 acl released,macrophages
R2501 T3125 T3126 nummod TLR4,ligands
R2502 T3114 T3113 agent by,released
R2503 T3126 T3120 pobj ligands,of
R2504 T3127 T3126 acl involved,ligands
R2505 T3115 T3116 amod necrotic,cells
R2506 T3116 T3114 pobj cells,by
R2507 T3128 T3127 prep in,involved
R2508 T3129 T3130 compound RA,pathology
R2509 T3130 T3128 pobj pathology,in
R2510 T3131 T3118 punct .,is
R2511 T3132 T3134 nsubjpass HMGB1,increased
R2512 T3214 T3210 relcl involved,ligands
R2513 T3215 T3214 prep in,involved
R2514 T3133 T3134 auxpass is,increased
R2515 T3216 T3217 compound RA,pathology
R2516 T3217 T3215 pobj pathology,in
R2517 T3218 T3218 ROOT are,are
R2518 T3134 T3134 ROOT increased,increased
R2519 T3219 T3221 amod extracellular,components
R2520 T3220 T3221 compound matrix,components
R2521 T3135 T3134 prep in,increased
R2522 T3221 T3218 attr components,are
R2523 T3222 T3223 amod such,as
R2524 T3223 T3221 prep as,components
R2525 T3136 T3138 nmod RA,tissue
R2526 T3224 T3223 pobj fibrinogen,as
R2527 T3225 T3224 punct ",",fibrinogen
R2528 T3137 T3138 amod synovial,tissue
R2529 T3226 T3224 conj fibronectin,fibrinogen
R2530 T3227 T3226 punct ",",fibronectin
R2531 T3228 T3226 conj biglycan,fibronectin
R2532 T3138 T3135 pobj tissue,in
R2533 T3229 T3228 punct ",",biglycan
R2534 T3230 T3231 compound tenascin,C
R2535 T3231 T3228 conj C,biglycan
R2536 T3139 T3138 cc and,tissue
R2537 T3232 T3231 punct ",",C
R2538 T3233 T3231 cc and,C
R2539 T3234 T3236 amod hyal-uronic,fragments
R2540 T3140 T3141 nsubj HMGB1,neutralising
R2541 T3235 T3236 compound acid,fragments
R2542 T3236 T3231 conj fragments,C
R2543 T3237 T3236 punct (,fragments
R2544 T3141 T3138 conj neutralising,tissue
R2545 T3238 T3236 acl reviewed,fragments
R2546 T3239 T3238 prep in,reviewed
R2547 T3142 T3141 dobj antibodies,neutralising
R2548 T3240 T3239 pobj [,in
R2549 T3241 T3242 nummod "14,15",]
R2550 T3143 T3142 cc or,antibodies
R2551 T3242 T3240 appos ],[
R2552 T3243 T3240 punct ),[
R2553 T3244 T3218 punct .,are
R2554 T3144 T3147 det the,domain
R2555 T3245 T3249 advmod Together,suggest
R2556 T3246 T3249 punct ",",suggest
R2557 T3247 T3248 det these,studies
R2558 T3145 T3147 amod antagonistic,domain
R2559 T3248 T3249 nsubj studies,suggest
R2560 T3249 T3249 ROOT suggest,suggest
R2561 T3250 T3260 mark that,contribute
R2562 T3146 T3147 compound BoxA,domain
R2563 T3251 T3253 amod several,ligands
R2564 T3252 T3253 compound TLR,ligands
R2565 T3253 T3260 nsubj ligands,contribute
R2566 T3147 T3142 conj domain,antibodies
R2567 T3254 T3253 prep in,ligands
R2568 T3255 T3258 det the,tissue
R2569 T3256 T3258 amod inflamed,tissue
R2570 T3148 T3147 prep of,domain
R2571 T3257 T3258 amod joint,tissue
R2572 T3258 T3254 pobj tissue,in
R2573 T3259 T3260 aux may,contribute
R2574 T3149 T3148 pobj HMGB1,of
R2575 T3260 T3249 ccomp contribute,suggest
R2576 T3261 T3260 prep to,contribute
R2577 T3262 T3263 amod NF-κB,activation
R2578 T3263 T3261 pobj activation,to
R2579 T3264 T3263 cc and,activation
R2580 T3265 T3267 amod inflammatory,expression
R2581 T3150 T3134 conj protect,increased
R2582 T3266 T3267 compound gene,expression
R2583 T3267 T3263 conj expression,activation
R2584 T3268 T3263 prep in,activation
R2585 T3151 T3150 prep against,protect
R2586 T3269 T3268 pobj RA,in
R2587 T3270 T3249 punct .,suggest
R2588 T3152 T3153 amod collagen-induced,arthritis
R2589 T3153 T3151 pobj arthritis,against
R2590 T3154 T3153 prep in,arthritis
R2591 T3155 T3154 pobj mice,in
R2592 T3156 T3158 nmod [,]
R2593 T3157 T3158 nummod 16,]
R2594 T3158 T3158 ROOT ],]
R2595 T3159 T3134 punct .,increased
R2596 T3160 T3161 amod Myeloid-related,protein
R2597 T3161 T3181 nsubj protein,are
R2598 T3162 T3161 nummod 8,protein
R2599 T3163 T3161 cc and,protein
R2600 T3164 T3165 amod myeloid-related,protein
R2601 T3165 T3161 conj protein,protein
R2602 T3166 T3165 nummod 14,protein
R2603 T3167 T3165 punct ",",protein
R2604 T3168 T3171 amod damage-associated,molecules
R2605 T3169 T3170 amod molecular,pattern
R2606 T3170 T3171 compound pattern,molecules
R2607 T3171 T3165 conj molecules,protein
R2608 T3172 T3171 acl belonging,molecules
R2609 T3173 T3172 prep to,belonging
R2610 T3174 T3176 det the,family
R2611 T3175 T3176 compound S100,family
R2615 T3176 T3173 pobj family,to
R2620 T3177 T3176 prep of,family
R2622 T3178 T3179 amod calcium-binding,proteins
R2624 T3179 T3177 pobj proteins,of
R2625 T3180 T3181 punct ",",are
R2626 T3181 T3181 ROOT are,are
R2631 T3182 T3181 advmod also,are
R2632 T3183 T3184 advmod abundantly,present
R2634 T3184 T3181 acomp present,are
R2635 T3185 T3184 prep in,present
R2636 T3186 T3188 nmod RA,fluid
R2639 T3187 T3188 compound synovial,fluid
R2640 T3188 T3185 pobj fluid,in
R2641 T3189 T3181 punct ",",are
R2642 T3190 T3181 cc and,are
R2643 T3191 T3193 aux have,suggested
R2644 T3192 T3193 auxpass been,suggested
R2645 T3193 T3181 conj suggested,are
R2646 T3194 T3196 aux to,involved
R2647 T3195 T3196 auxpass be,involved
R2649 T3196 T3193 xcomp involved,suggested
R2650 T3197 T3196 prep in,involved
R2651 T3198 T3200 amod TLR4-induced,inflammation
R2653 T3199 T3200 amod chronic,inflammation
R2655 T3200 T3197 pobj inflammation,in
R2657 T3201 T3200 prep in,inflammation
R2659 T3202 T3203 compound RA,[
R2660 T3203 T3201 pobj [,in
R2661 T3204 T3205 nummod "17,18",]
R2665 T3205 T3193 conj ],suggested
R2668 T3206 T3181 punct .,are
R2669 T3207 T3210 amod Other,ligands
R2674 T3208 T3210 amod endogenous,ligands
R2677 T3209 T3210 compound TLR,ligands
R2678 T3210 T3218 nsubj ligands,are
R2679 T3211 T3214 nsubjpass that,involved
R2680 T3212 T3214 aux may,involved
R2681 T3213 T3214 auxpass be,involved
R3980 T5918 T5920 nsubjpass proteins,sequestered
R3981 T5919 T5920 auxpass are,sequestered
R3982 T5920 T5920 ROOT sequestered,sequestered
R3983 T5921 T5920 prep in,sequestered
R3984 T5922 T5923 det the,cytoplasm
R3985 T5923 T5921 pobj cytoplasm,in
R3986 T5924 T5920 prep as,sequestered
R3987 T5925 T5926 amod latent,complexes
R3988 T5926 T5924 pobj complexes,as
R3989 T5927 T5920 agent by,sequestered
R3990 T5928 T5929 amod inhibitory,proteins
R3991 T5929 T5927 pobj proteins,by
R3992 T5930 T5920 conj referred,sequestered
R3993 T5931 T5930 prep to,referred
R3994 T5932 T5930 prep as,referred
R3995 T5933 T5932 pobj inhibitor,as
R3996 T5934 T5933 prep of,inhibitor
R3997 T5935 T5934 pobj NF-κB,of
R3998 T5936 T5935 punct (,NF-κB
R3999 T5937 T5935 appos IκB,NF-κB
R4001 T5938 T5935 punct ),NF-κB
R4004 T5939 T5934 pobj proteins,of
R4007 T5962 T5961 punct ",",IκBβ
R4008 T5940 T5939 punct ",",proteins
R4009 T5963 T5961 conj IκBε,IκBβ
R4010 T5964 T5963 punct ",",IκBε
R4011 T5965 T5963 conj p105,IκBε
R4012 T5941 T5942 nsubj which,prevent
R4013 T5966 T5965 punct (,p105
R4014 T5967 T5968 advmod also,known
R4015 T5968 T5965 acl known,p105
R4016 T5942 T5939 relcl prevent,proteins
R4017 T5969 T5968 prep as,known
R4018 T5970 T5969 pobj NF-κB1,as
R4019 T5943 T5945 amod NF-κB,translocation
R4020 T5944 T5945 amod nuclear,translocation
R4021 T5945 T5942 dobj translocation,prevent
R4022 T5971 T5965 punct ),p105
R4023 T5972 T5959 punct ",",IκBα
R4024 T5946 T5945 cc and,translocation
R4025 T5973 T5957 appos p100,IκBs
R4026 T5974 T5976 punct (,known
R4027 T5947 T5948 npadvmod DNA,binding
R4028 T5975 T5976 advmod also,known
R4029 T5976 T5973 acl known,p100
R4030 T5977 T5976 prep as,known
R4031 T5948 T5951 amod binding,]
R4032 T5978 T5977 pobj NF-κB2,as
R4033 T5979 T5973 punct ),p100
R4034 T5949 T5951 nmod [,]
R4035 T5980 T5955 punct ),majority
R4036 T5981 T5981 ROOT serve,serve
R4037 T5982 T5981 prep as,serve
R4038 T5983 T5982 pobj inhibitors,as
R4039 T5950 T5951 nummod 19,]
R4040 T5984 T5983 prep of,inhibitors
R4041 T5985 T5984 pobj NF-κB,of
R4042 T5986 T5985 punct ",",NF-κB
R4043 T5987 T5985 conj IκBξ,NF-κB
R4044 T5988 T5987 cc and,IκBξ
R4045 T5989 T5987 conj Bcl-3,IκBξ
R4046 T5951 T5945 conj ],translocation
R4047 T5990 T5993 nmod instead,transactivation
R4048 T5991 T5993 amod potentiate,transactivation
R4049 T5992 T5993 compound NF-κB,transactivation
R4050 T5993 T5983 conj transactivation,inhibitors
R4051 T5952 T5920 punct .,sequestered
R4052 T5994 T5993 prep in,transactivation
R4053 T5995 T5996 det the,nucleus
R4054 T5953 T5981 mark Whereas,serve
R4055 T5996 T5994 pobj nucleus,in
R4056 T5997 T5981 punct .,serve
R4057 T5998 T6001 nsubj p100,are
R4058 T5954 T5955 det the,majority
R4059 T5999 T5998 cc and,p100
R4060 T6000 T5998 conj p105,p100
R4061 T6001 T6001 ROOT are,are
R4062 T6002 T6001 attr precursors,are
R4063 T5955 T5981 nsubj majority,serve
R4064 T6003 T6002 prep of,precursors
R4065 T6004 T6005 det the,p52
R4066 T5956 T5955 prep of,majority
R4067 T6005 T6009 nummod p52,subunits
R4068 T6006 T6005 cc and,p52
R4069 T6007 T6005 conj p50,p52
R4070 T6008 T6009 amod NF-κB,subunits
R4072 T6009 T6003 pobj subunits,of
R4073 T6010 T6009 punct ",",subunits
R4074 T6011 T6001 advmod respectively,are
R4075 T6012 T6001 punct .,are
R4076 T6013 T6014 expl There,are
R4077 T6014 T6014 ROOT are,are
R4078 T6015 T6019 nummod two,pathways
R4080 T6016 T6019 amod unique,pathways
R4081 T6017 T6018 npadvmod NF-κB,signalling
R4082 T6018 T6019 amod signalling,pathways
R4083 T6019 T6014 attr pathways,are
R4085 T6020 T6019 punct ",",pathways
R4086 T6021 T6019 acl termed,pathways
R4087 T6022 T6021 oprd canonical,termed
R4088 T6057 T6058 amod proinflammatory,cytokines
R4089 T6023 T6022 punct (,canonical
R4090 T6024 T6022 cc or,canonical
R4091 T6058 T6056 pobj cytokines,including
R4092 T6059 T6058 punct (,cytokines
R4093 T6025 T6022 conj classical,canonical
R4094 T6026 T6019 punct ),pathways
R4095 T6027 T6014 cc and,are
R4096 T6028 T6014 conj noncanonical,are
R4097 T6029 T6028 punct (,noncanonical
R4098 T6030 T6028 cc or,noncanonical
R4099 T6060 T6058 prep for,cytokines
R4100 T6031 T6028 conj alternative,noncanonical
R4101 T6032 T6028 punct ),noncanonical
R4102 T6061 T6060 pobj example,for
R4103 T6033 T6034 compound NF-κB,pathways
R4104 T6034 T6014 attr pathways,are
R4105 T6062 T6068 punct ",",antigens
R4106 T6035 T6014 punct .,are
R4107 T6036 T6039 det The,pathway
R4108 T6037 T6039 amod canonical,pathway
R4109 T6063 T6068 nmod TNF,antigens
R4110 T6038 T6039 compound NF-κB,pathway
R4111 T6039 T6040 nsubj pathway,plays
R4112 T6040 T6040 ROOT plays,plays
R4113 T6041 T6043 det a,role
R4114 T6064 T6063 punct ",",TNF
R4115 T6042 T6043 amod major,role
R4116 T6043 T6040 dobj role,plays
R4117 T6044 T6043 prep in,role
R4118 T6065 T6063 conj IL-1,TNF
R4119 T6045 T6048 amod innate,immunity
R4120 T6046 T6045 cc and,innate
R4121 T6047 T6045 conj adaptive,innate
R4122 T6066 T6065 punct ),IL-1
R4123 T6048 T6044 pobj immunity,in
R4124 T6049 T6040 punct ",",plays
R4125 T6050 T6040 cc and,plays
R4126 T6067 T6065 punct ",",IL-1
R4127 T6051 T6052 auxpass is,triggered
R4128 T6052 T6040 conj triggered,plays
R4129 T6053 T6052 agent by,triggered
R4130 T6068 T6058 conj antigens,cytokines
R4131 T6069 T6068 punct ",",antigens
R4132 T6070 T6068 conj RANKL,antigens
R4133 T6071 T6070 punct ",",RANKL
R4134 T6151 T6150 punct ),IKKβ
R4135 T6072 T6070 cc and,RANKL
R4136 T6152 T6146 cc and,known
R4137 T6153 T6155 det the,subunit
R4138 T6073 T6070 conj TLR,RANKL
R4139 T6154 T6155 amod regulatory,subunit
R4140 T6155 T6146 conj subunit,known
R4141 T6156 T6158 nmod NF-κB,modulator
R4142 T6074 T6070 conj ligands,RANKL
R4143 T6157 T6158 amod essential,modulator
R4144 T6158 T6155 appos modulator,subunit
R4145 T6159 T6163 punct (,known
R4146 T6160 T6163 punct NEMO,known
R4147 T6161 T6163 punct -,known
R4148 T6162 T6163 advmod also,known
R4149 T6075 T6040 punct .,plays
R4150 T6163 T6155 acl known,subunit
R4151 T6164 T6163 prep as,known
R4152 T6165 T6164 pobj IKKγ,as
R4153 T6076 T6077 amod NF-κB,signalling
R4154 T6166 T6140 punct ),subunits
R4155 T6167 T6168 punct (,Figure
R4156 T6077 T6082 nsubj signalling,requires
R4157 T6168 T6140 appos Figure,subunits
R4158 T6169 T6168 nummod 1,Figure
R4159 T6078 T6077 acl initiated,signalling
R4160 T6170 T6168 punct ),Figure
R4161 T6171 T6135 punct .,comprised
R4162 T6172 T6174 compound Gene,experiments
R4163 T6173 T6174 compound targeting,experiments
R4164 T6079 T6078 agent by,initiated
R4165 T6174 T6175 nsubj experiments,showed
R4166 T6175 T6175 ROOT showed,showed
R4167 T6176 T6186 mark that,required
R4168 T6080 T6081 amod different,receptors
R4169 T6177 T6186 nsubjpass IKK2,required
R4170 T6178 T6177 cc and,IKK2
R4171 T6081 T6079 pobj receptors,by
R4172 T6082 T6082 ROOT requires,requires
R4173 T6179 T6177 conj NEMO,IKK2
R4174 T6180 T6177 punct ",",IKK2
R4175 T6181 T6177 cc but,IKK2
R4176 T6083 T6084 det the,formation
R4177 T6182 T6183 neg not,IKK1
R4178 T6183 T6177 conj IKK1,IKK2
R4179 T6184 T6186 punct ",",required
R4180 T6185 T6186 auxpass are,required
R4181 T6084 T6082 dobj formation,requires
R4182 T6186 T6175 ccomp required,showed
R4183 T6085 T6084 prep of,formation
R4184 T6187 T6186 prep for,required
R4185 T6086 T6088 amod proximal,interactions
R4186 T6188 T6190 amod canonical,activation
R4187 T6087 T6088 compound protein-protein,interactions
R4188 T6189 T6190 compound NF-κB,activation
R4189 T6190 T6187 pobj activation,for
R4190 T6088 T6085 pobj interactions,of
R4191 T6191 T6193 nmod [,]
R4192 T6192 T6193 nummod 21,]
R4193 T6193 T6190 appos ],activation
R4194 T6194 T6175 punct .,showed
R4195 T6195 T6203 nsubj One,is
R4196 T6196 T6195 prep of,One
R4197 T6089 T6090 nsubj that,are
R4198 T6197 T6198 det the,best
R4199 T6198 T6199 advmod best,studied
R4200 T6199 T6200 amod studied,NF-κB
R4201 T6090 T6088 relcl are,interactions
R4202 T6200 T6201 nsubj NF-κB,signalling
R4203 T6201 T6203 csubj signalling,is
R4204 T6202 T6201 dobj pathways,signalling
R4205 T6091 T6090 advmod often,are
R4206 T6203 T6203 ROOT is,is
R4207 T6204 T6206 det the,pathway
R4208 T6205 T6206 compound TNF,pathway
R4209 T6092 T6093 npadvmod receptor,specific
R4210 T6206 T6203 attr pathway,is
R4211 T6207 T6203 punct .,is
R4212 T6093 T6090 acomp specific,are
R4213 T6208 T6210 compound TNF,results
R4214 T6209 T6210 compound stimulation,results
R4215 T6210 T6210 ROOT results,results
R4216 T6094 T6082 punct ",",requires
R4217 T6211 T6210 prep in,results
R4218 T6212 T6213 det the,recruitment
R4219 T6213 T6211 pobj recruitment,in
R4220 T6095 T6082 cc but,requires
R4221 T6214 T6213 prep of,recruitment
R4222 T6215 T6218 nmod TNF,domain
R4223 T6216 T6218 amod receptor-1-associated,domain
R4224 T6096 T6097 advmod ultimately,converge
R4225 T6217 T6218 compound death,domain
R4226 T6218 T6214 pobj domain,of
R4227 T6219 T6218 punct (,domain
R4228 T6097 T6082 conj converge,requires
R4229 T6220 T6218 appos TRADD,domain
R4230 T6221 T6220 punct ),TRADD
R4231 T6222 T6218 conj protein,domain
R4232 T6098 T6097 prep in,converge
R4233 T6223 T6214 cc and,of
R4234 T6224 T6214 conj of,of
R4235 T6225 T6227 compound receptor,protein
R4236 T6099 T6100 det the,activation
R4237 T6226 T6227 compound interacting,protein
R4238 T6227 T6224 pobj protein,of
R4239 T6228 T6227 nummod 1,protein
R4240 T6100 T6098 pobj activation,in
R4241 T6229 T6227 punct (,protein
R4242 T6230 T6227 appos RIP1,protein
R4243 T6231 T6230 punct ),RIP1
R4244 T6232 T6227 punct ",",protein
R4245 T6233 T6234 nsubj which,function
R4246 T6234 T6210 relcl function,results
R4247 T6101 T6100 prep of,activation
R4248 T6235 T6234 prep as,function
R4249 T6236 T6237 compound adaptor,proteins
R4250 T6237 T6235 pobj proteins,as
R4251 T6238 T6234 prep for,function
R4252 T6102 T6104 det the,kinase
R4253 T6239 T6245 det the,factor
R4254 T6240 T6241 nummod E3,ubiquitin
R4255 T6103 T6104 compound IκB,kinase
R4256 T6241 T6242 nsubj ubiquitin,ligases
R4257 T6242 T6245 nmod ligases,factor
R4258 T6243 T6245 nmod TNF,factor
R4259 T6104 T6101 pobj kinase,of
R4260 T6244 T6245 amod receptor-associated,factor
R4261 T6245 T6238 pobj factor,for
R4262 T6105 T6106 punct (,IKK
R4263 T6246 T6247 punct (,TRAF
R4264 T6247 T6245 appos TRAF,factor
R4265 T6106 T6104 appos IKK,kinase
R4266 T6107 T6106 punct ),IKK
R4267 T6108 T6104 conj complex,kinase
R4268 T6109 T6104 punct ",",kinase
R4269 T6248 T6247 punct ),TRAF
R4270 T6249 T6247 nummod 2,TRAF
R4271 T6110 T6111 nsubj which,mediates
R4272 T6250 T6247 cc and,TRAF
R4273 T6251 T6247 conj TRAF5,TRAF
R4274 T6252 T6245 punct ",",factor
R4275 T6111 T6104 relcl mediates,kinase
R4276 T6253 T6256 nsubj which,bind
R4277 T6254 T6256 prep in,bind
R4278 T6255 T6254 pobj turn,in
R4279 T6112 T6111 dobj phosphorylation,mediates
R4280 T6256 T6245 relcl bind,factor
R4281 T6113 T6112 prep of,phosphorylation
R4282 T6114 T6117 det the,protein
R4283 T6257 T6260 dobj the,ligases
R4284 T6258 T6259 nummod E3,ubiquitin
R4285 T6115 T6117 amod inhibitory,protein
R4286 T6259 T6260 nsubj ubiquitin,ligases
R4287 T6260 T6256 dative ligases,bind
R4288 T6261 T6262 amod cellular,inhibitor
R4289 T6116 T6117 compound IκB,protein
R4290 T6262 T6256 dobj inhibitor,bind
R4291 T6263 T6262 prep of,inhibitor
R4292 T6117 T6113 pobj protein,of
R4293 T6264 T6263 pobj apoptosis,of
R4294 T6265 T6266 punct (,cIAP
R4295 T6266 T6264 appos cIAP,apoptosis
R4296 T6267 T6256 punct ),bind
R4297 T6268 T6256 nummod 1,bind
R4298 T6118 T6117 acl leading,protein
R4299 T6269 T6256 cc and,bind
R4300 T6270 T6274 nmod cIAP2,)
R4301 T6271 T6272 punct (,Figure
R4302 T6119 T6118 prep to,leading
R4303 T6272 T6270 appos Figure,cIAP2
R4304 T6273 T6272 nummod 1,Figure
R4305 T6274 T6256 conj ),bind
R4306 T6275 T6210 punct .,results
R4307 T6120 T6121 poss its,K48-polyubiquitination
R4308 T6276 T6285 prep On,modified
R4309 T6277 T6278 compound TNF,stimulation
R4310 T6121 T6119 pobj K48-polyubiquitination,to
R4311 T6278 T6276 pobj stimulation,On
R4312 T6279 T6285 punct ",",modified
R4313 T6280 T6282 amod TNF-receptor,RIP1
R4314 T6122 T6121 cc and,K48-polyubiquitination
R4315 T6281 T6282 amod bound,RIP1
R4316 T6282 T6285 nsubjpass RIP1,modified
R4317 T6283 T6285 auxpass is,modified
R4318 T6123 T6121 conj degradation,K48-polyubiquitination
R4319 T6284 T6285 advmod rapidly,modified
R4320 T6285 T6285 ROOT modified,modified
R4321 T6124 T6121 prep by,K48-polyubiquitination
R4322 T6286 T6285 agent by,modified
R4323 T6287 T6289 amod K63-linked,chains
R4324 T6288 T6289 compound polyubiquitin,chains
R4325 T6125 T6129 det the,]
R4326 T6289 T6286 pobj chains,by
R4327 T6290 T6285 punct .,modified
R4328 T6291 T6294 nsubj TRAF2/5,are
R4329 T6126 T6127 compound proteasome,[
R4330 T6292 T6291 cc and,TRAF2/5
R4331 T6293 T6291 conj cIAP1/2,TRAF2/5
R4332 T6127 T6129 nmod [,]
R4333 T6294 T6294 ROOT are,are
R4334 T6295 T6296 amod good,candidates
R4335 T6296 T6294 attr candidates,are
R4336 T6128 T6129 nummod 20,]
R4337 T6297 T6296 prep for,candidates
R4338 T6298 T6299 compound RIP1,ubiquitination
R4339 T6299 T6297 pobj ubiquitination,for
R4340 T6129 T6124 pobj ],by
R4341 T6300 T6294 punct ",",are
R4342 T6301 T6294 cc but,are
R4343 T6130 T6082 punct .,requires
R4344 T6302 T6304 det the,role
R4345 T6303 T6304 amod specific,role
R4346 T6304 T6307 nsubj role,is
R4347 T6305 T6304 prep of,role
R4348 T6306 T6305 pobj each,of
R4349 T6307 T6294 conj is,are
R4350 T6131 T6133 det The,complex
R4351 T6308 T6307 advmod still,is
R4352 T6309 T6307 acomp unclear,is
R4353 T6310 T6307 punct .,is
R4354 T6132 T6133 compound IKK,complex
R4355 T6311 T6313 det The,chains
R4356 T6312 T6313 compound polyubiquitin,chains
R4357 T6313 T6317 nsubjpass chains,believed
R4358 T6133 T6135 nsubjpass complex,comprised
R4359 T6314 T6313 prep on,chains
R4360 T6315 T6314 pobj RIP1,on
R4361 T6134 T6135 auxpass is,comprised
R4362 T6316 T6317 auxpass are,believed
R4363 T6317 T6317 ROOT believed,believed
R4364 T6318 T6319 aux to,create
R4365 T6135 T6135 ROOT comprised,comprised
R4366 T6319 T6317 xcomp create,believed
R4367 T6320 T6321 det a,scaffold
R4368 T6321 T6319 dobj scaffold,create
R4369 T6136 T6135 prep of,comprised
R4370 T6322 T6323 aux to,recruit
R4371 T6323 T6319 advcl recruit,create
R4372 T6137 T6140 det the,subunits
R4373 T6324 T6325 det the,IKK
R4374 T6325 T6323 dobj IKK,recruit
R4375 T6326 T6325 cc and,IKK
R4376 T6138 T6140 nummod two,subunits
R4377 T6327 T6328 nummod TAK1,complex
R4378 T6328 T6317 conj complex,believed
R4379 T6139 T6140 amod catalytic,subunits
R4380 T6329 T6328 prep via,complex
R4381 T6330 T6332 det the,proteins
R4382 T6331 T6332 amod ubiquitin-binding,proteins
R4383 T6332 T6329 pobj proteins,via
R4384 T6140 T6136 pobj subunits,of
R4385 T6333 T6332 appos NEMO,proteins
R4386 T6334 T6333 cc and,NEMO
R4387 T6141 T6140 appos IKK1,subunits
R4388 T6335 T6333 conj TAB1/2,NEMO
R4389 T6142 T6141 cc and,IKK1
R4390 T6143 T6141 conj IKK2,IKK1
R4391 T6336 T6335 punct ",",TAB1/2
R4392 T6337 T6333 conj respectively,NEMO
R4393 T6144 T6146 punct (,known
R4394 T6338 T6317 punct .,believed
R4395 T6339 T6341 det The,identification
R4396 T6340 T6341 amod recent,identification
R4397 T6341 T6356 nsubj identification,is
R4398 T6342 T6341 prep of,identification
R4399 T6343 T6347 det a,complex
R4400 T6145 T6146 advmod also,known
R4401 T6344 T6347 amod distinct,complex
R4402 T6146 T6141 parataxis known,IKK1
R4403 T6147 T6146 prep as,known
R4404 T6148 T6147 pobj IKKα,as
R4405 T6345 T6346 nummod E2/E3,enzyme
R4406 T6346 T6347 compound enzyme,complex
R4407 T6149 T6148 cc and,IKKα
R4408 T6347 T6342 pobj complex,of
R4409 T6348 T6349 nsubj that,modifies
R4410 T6349 T6347 relcl modifies,complex
R4411 T6150 T6148 conj IKKβ,IKKα
R4412 T6350 T6349 dobj NEMO,modifies
R4413 T6351 T6349 prep with,modifies
R4414 T6442 T6443 amod bridging,factors
R4415 T6352 T6354 amod linear,chains
R4416 T6353 T6354 compound polyubiquitin,chains
R4417 T6354 T6351 pobj chains,with
R4418 T6355 T6349 cc and,modifies
R4419 T6356 T6362 ccomp is,adds
R4420 T6357 T6356 acomp essential,is
R4421 T6443 T6441 pobj factors,as
R4422 T6358 T6357 prep for,essential
R4423 T6359 T6361 amod TNF-activated,signalling
R4424 T6444 T6445 aux to,recruit
R4425 T6360 T6361 compound NF-κB,signalling
R4426 T6361 T6358 pobj signalling,for
R4427 T6362 T6362 ROOT adds,adds
R4428 T6363 T6364 amod further,complexity
R4429 T6445 T6440 advcl recruit,serve
R4430 T6364 T6362 dobj complexity,adds
R4431 T6365 T6367 nmod [,]
R4432 T6366 T6367 nummod 22,]
R4433 T6446 T6450 amod myeloid,gene
R4434 T6367 T6362 npadvmod ],adds
R4435 T6368 T6362 punct .,adds
R4436 T6369 T6371 det The,role
R4437 T6447 T6450 nmod differentiation,gene
R4438 T6370 T6371 amod exact,role
R4439 T6371 T6376 nsubj role,remains
R4440 T6448 T6450 amod primary,gene
R4441 T6372 T6371 prep of,role
R4442 T6373 T6375 amod protein-anchored,chains
R4443 T6374 T6375 compound polyubiquitin,chains
R4444 T6375 T6372 pobj chains,of
R4445 T6449 T6450 compound response,gene
R4446 T6376 T6376 ROOT remains,remains
R4447 T6377 T6376 acomp unclear,remains
R4448 T6378 T6376 punct ",",remains
R4449 T6379 T6383 mark as,suggested
R4450 T6380 T6383 nsubjpass it,suggested
R4451 T6381 T6383 auxpass was,suggested
R4452 T6450 T6445 dobj gene,recruit
R4453 T6382 T6383 advmod recently,suggested
R4454 T6383 T6376 advcl suggested,remains
R4455 T6384 T6390 mark that,activate
R4456 T6451 T6450 nummod 88,gene
R4457 T6385 T6387 amod unanchored,chains
R4458 T6386 T6387 compound polyubiquitin,chains
R4459 T6387 T6390 nsubj chains,activate
R4460 T6388 T6390 aux can,activate
R4461 T6452 T6453 punct (,MyD88
R4462 T6389 T6390 advmod directly,activate
R4463 T6390 T6383 ccomp activate,suggested
R4464 T6391 T6396 det the,]
R4465 T6453 T6450 appos MyD88,gene
R4466 T6392 T6396 nummod TAK1,]
R4467 T6393 T6394 amod complex,[
R4468 T6394 T6396 nmod [,]
R4469 T6454 T6453 punct ),MyD88
R4470 T6395 T6396 nummod 23,]
R4471 T6396 T6390 dobj ],activate
R4472 T6455 T6440 cc and,serve
R4473 T6397 T6376 punct .,remains
R4474 T6398 T6400 amod Similar,principles
R4475 T6399 T6400 amod signalling,principles
R4476 T6456 T6459 compound TIR,IFNβ
R4477 T6400 T6401 nsubj principles,apply
R4478 T6401 T6401 ROOT apply,apply
R4479 T6402 T6401 prep to,apply
R4480 T6457 T6459 compound domain-containing,IFNβ
R4481 T6403 T6404 amod other,receptors
R4482 T6404 T6402 pobj receptors,to
R4483 T6405 T6401 punct .,apply
R4484 T6458 T6459 compound adaptor-inducing,IFNβ
R4485 T6406 T6413 prep For,induces
R4486 T6407 T6406 pobj example,For
R4487 T6408 T6413 punct ",",induces
R4488 T6459 T6432 appos IFNβ,molecule
R4489 T6409 T6410 nummod TLR4,stimulation
R4490 T6410 T6413 nsubj stimulation,induces
R4491 T6411 T6410 prep by,stimulation
R4492 T6460 T6459 punct (,IFNβ
R4493 T6412 T6411 pobj lipopolysaccharide,by
R4494 T6413 T6413 ROOT induces,induces
R4495 T6461 T6459 appos TRIF,IFNβ
R4496 T6414 T6415 det the,recruitment
R4497 T6415 T6413 dobj recruitment,induces
R4498 T6416 T6415 prep of,recruitment
R4499 T6462 T6459 punct ),IFNβ
R4500 T6417 T6421 nmod Toll/IL,protein
R4501 T6418 T6421 nummod -1,protein
R4502 T6419 T6420 compound receptor,adaptor
R4503 T6420 T6421 compound adaptor,protein
R4504 T6463 T6459 punct ",",IFNβ
R4505 T6421 T6416 pobj protein,of
R4506 T6422 T6424 punct (,referred
R4507 T6464 T6459 advmod respectively,IFNβ
R4508 T6423 T6424 advmod also,referred
R4509 T6424 T6424 ROOT referred,referred
R4510 T6425 T6424 prep to,referred
R4511 T6465 T6424 punct .,referred
R4512 T6426 T6425 prep as,to
R4513 T6427 T6426 pobj Mal,as
R4514 T6428 T6425 punct ),to
R4515 T6466 T6469 nummod MyD88,recruits
R4516 T6429 T6424 cc and,referred
R4517 T6430 T6432 amod TRIF-related,molecule
R4518 T6431 T6432 compound adaptor,molecule
R4519 T6467 T6469 prep in,recruits
R4520 T6432 T6424 conj molecule,referred
R4521 T6433 T6434 punct (,TRAM
R4522 T6468 T6467 pobj turn,in
R4523 T6434 T6432 appos TRAM,molecule
R4524 T6435 T6434 punct ),TRAM
R4525 T6436 T6432 punct ",",molecule
R4526 T6469 T6469 ROOT recruits,recruits
R4527 T6437 T6440 nsubj which,serve
R4528 T6438 T6439 advmod most,probably
R4529 T6439 T6440 advmod probably,serve
R4530 T6440 T6432 relcl serve,molecule
R4531 T6470 T6469 dobj members,recruits
R4532 T6441 T6440 prep as,serve
R4533 T6471 T6470 prep of,members
R4534 T6472 T6474 det the,kinase
R4535 T6473 T6474 amod IL-1R-associated,kinase
R4536 T6539 T6542 det the,receptor
R4537 T6540 T6542 nmod lymphotoxin,receptor
R4538 T6474 T6471 pobj kinase,of
R4539 T6541 T6542 compound β,receptor
R4540 T6542 T6538 pobj receptor,by
R4541 T6475 T6474 punct (,kinase
R4542 T6543 T6542 punct ",",receptor
R4543 T6544 T6545 compound BAFF,receptor
R4544 T6545 T6542 conj receptor,receptor
R4545 T6476 T6474 appos IRAK,kinase
R4546 T6546 T6545 punct ",",receptor
R4547 T6547 T6545 conj CD40,receptor
R4548 T6548 T6547 punct ",",CD40
R4549 T6549 T6547 cc and,CD40
R4550 T6550 T6547 conj RANK,CD40
R4551 T6551 T6552 punct (,Figure
R4552 T6552 T6550 appos Figure,RANK
R4553 T6477 T6476 punct ),IRAK
R4554 T6478 T6474 conj family,kinase
R4555 T6553 T6552 nummod 2,Figure
R4556 T6479 T6478 cc and,family
R4557 T6554 T6550 punct ),RANK
R4558 T6555 T6537 punct .,activated
R4559 T6480 T6478 conj TRAF6,family
R4560 T6556 T6562 prep In,processed
R4561 T6557 T6558 det this,pathway
R4562 T6481 T6469 punct ",",recruits
R4563 T6558 T6556 pobj pathway,In
R4564 T6559 T6562 punct ",",processed
R4565 T6560 T6562 nsubjpass p100,processed
R4566 T6561 T6562 auxpass is,processed
R4567 T6482 T6469 advcl leading,recruits
R4568 T6562 T6562 ROOT processed,processed
R4569 T6563 T6562 agent by,processed
R4570 T6483 T6482 prep to,leading
R4571 T6564 T6565 det the,proteasome
R4572 T6565 T6563 pobj proteasome,by
R4573 T6566 T6565 prep to,proteasome
R4574 T6484 T6483 pobj oligomerisation,to
R4575 T6567 T6566 pobj p52,to
R4576 T6568 T6567 punct ",",p52
R4577 T6485 T6484 cc and,oligomerisation
R4578 T6569 T6576 nsubj which,regulates
R4579 T6486 T6484 conj selfubiquitination,oligomerisation
R4580 T6570 T6571 advmod together,with
R4581 T6487 T6486 prep of,selfubiquitination
R4582 T6571 T6576 prep with,regulates
R4583 T6572 T6575 det the,subunit
R4584 T6488 T6491 nummod TRAF6,]
R4585 T6573 T6575 compound RelB,subunit
R4586 T6574 T6575 compound NF-κB,subunit
R4587 T6575 T6571 pobj subunit,with
R4588 T6576 T6565 relcl regulates,proteasome
R4589 T6489 T6491 nmod [,]
R4590 T6577 T6579 det a,set
R4591 T6578 T6579 amod distinct,set
R4592 T6490 T6491 nummod 24,]
R4593 T6579 T6576 dobj set,regulates
R4594 T6580 T6579 prep of,set
R4595 T6581 T6582 compound target,genes
R4596 T6491 T6487 pobj ],of
R4597 T6582 T6580 pobj genes,of
R4598 T6583 T6584 nsubj that,control
R4599 T6584 T6582 relcl control,genes
R4600 T6585 T6586 amod B-cell,development
R4601 T6586 T6584 dobj development,control
R4602 T6587 T6586 punct ",",development
R4603 T6588 T6591 amod secondary,development
R4604 T6589 T6591 amod lymphoid,development
R4605 T6492 T6469 punct .,recruits
R4606 T6590 T6591 compound organ,development
R4607 T6591 T6586 conj development,development
R4608 T6592 T6591 punct ",",development
R4609 T6593 T6591 cc and,development
R4610 T6493 T6495 nsubj TRIF,recruits
R4611 T6594 T6595 compound osteoclastogenesis,[
R4612 T6595 T6579 appos [,set
R4613 T6596 T6597 nummod 27,]
R4614 T6494 T6495 advmod also,recruits
R4615 T6597 T6597 ROOT ],]
R4616 T6598 T6601 det The,pathway
R4617 T6599 T6601 amod noncanonical,pathway
R4618 T6495 T6495 ROOT recruits,recruits
R4619 T6600 T6601 compound NF-κB,pathway
R4620 T6601 T6602 nsubj pathway,is
R4621 T6496 T6499 nummod TRAF6,]
R4622 T6602 T6602 ROOT is,is
R4623 T6603 T6604 advmod strictly,dependent
R4624 T6604 T6602 acomp dependent,is
R4625 T6605 T6604 prep on,dependent
R4626 T6497 T6499 nmod [,]
R4627 T6606 T6605 pobj IKK1,on
R4628 T6498 T6499 nummod 25,]
R4629 T6607 T6606 punct ",",IKK1
R4630 T6608 T6610 nsubjpass which,activated
R4631 T6609 T6610 auxpass is,activated
R4632 T6499 T6495 dobj ],recruits
R4633 T6610 T6606 relcl activated,IKK1
R4634 T6611 T6610 prep upon,activated
R4635 T6612 T6611 pobj phosphorylation,upon
R4636 T6613 T6610 agent by,activated
R4637 T6500 T6499 cc and,]
R4638 T6614 T6615 advmod NF-κB,inducing
R4639 T6615 T6613 pcomp inducing,by
R4640 T6616 T6615 dobj kinase,inducing
R4641 T6501 T6502 compound RIP1,[
R4642 T6617 T6618 punct (,NIK
R4643 T6618 T6616 parataxis NIK,kinase
R4644 T6619 T6618 punct ),NIK
R4645 T6502 T6499 conj [,]
R4646 T6620 T6602 punct .,is
R4647 T6621 T6624 nsubjpass NIK,regulated
R4648 T6622 T6624 auxpass is,regulated
R4649 T6623 T6624 advmod predominantly,regulated
R4650 T6624 T6624 ROOT regulated,regulated
R4651 T6625 T6624 prep at,regulated
R4652 T6503 T6504 nummod 26,]
R4653 T6626 T6628 det the,level
R4654 T6627 T6628 amod post-translational,level
R4655 T6628 T6625 pobj level,at
R4656 T6629 T6624 cc and,regulated
R4657 T6504 T6499 conj ],]
R4658 T6630 T6624 conj is,regulated
R4659 T6631 T6630 acomp present,is
R4660 T6632 T6631 prep at,present
R4661 T6505 T6495 prep via,recruits
R4662 T6633 T6634 advmod extremely,low
R4663 T6634 T6635 amod low,levels
R4664 T6506 T6508 det a,interaction
R4665 T6635 T6632 pobj levels,at
R4666 T6507 T6508 amod direct,interaction
R4667 T6508 T6505 pobj interaction,via
R4668 T6636 T6635 prep in,levels
R4669 T6509 T6495 punct .,recruits
R4670 T6637 T6639 amod most,types
R4671 T6638 T6639 compound cell,types
R4672 T6639 T6636 pobj types,in
R4673 T6510 T6511 det Both,pathways
R4674 T6640 T6630 punct .,is
R4675 T6641 T6646 prep In,occurs
R4676 T6511 T6513 nsubj pathways,activate
R4677 T6642 T6643 amod unstimulated,cells
R4678 T6643 T6641 pobj cells,In
R4679 T6644 T6646 punct ",",occurs
R4680 T6512 T6513 advmod then,activate
R4681 T6645 T6646 nsubj NIK,occurs
R4682 T6646 T6646 ROOT occurs,occurs
R4683 T6513 T6513 ROOT activate,activate
R4684 T6647 T6646 prep in,occurs
R4685 T6514 T6513 dobj TAK1,activate
R4686 T6515 T6514 cc and,TAK1
R4687 T6648 T6650 det a,complex
R4688 T6649 T6650 compound cytoplasmic,complex
R4689 T6516 T6514 conj IKK,TAK1
R4690 T6650 T6647 pobj complex,in
R4691 T6651 T6650 prep with,complex
R4692 T6517 T6514 prep in,TAK1
R4693 T6652 T6651 pobj TRAF2,with
R4694 T6653 T6652 punct ",",TRAF2
R4695 T6654 T6652 conj TRAF3,TRAF2
R4696 T6518 T6520 det a,manner
R4697 T6655 T6646 punct ",",occurs
R4698 T6656 T6646 cc and,occurs
R4699 T6657 T6663 nsubj cIAP1/2,leading
R4700 T6658 T6657 punct ",",cIAP1/2
R4701 T6659 T6660 nsubj which,K48-polyubiquitinates
R4702 T6519 T6520 amod ubiquitination-dependent,manner
R4703 T6660 T6657 relcl K48-polyubiquitinates,cIAP1/2
R4704 T6661 T6660 dobj NIK,K48-polyubiquitinates
R4705 T6662 T6657 punct ",",cIAP1/2
R4706 T6520 T6517 pobj manner,in
R4707 T6663 T6646 conj leading,occurs
R4708 T6664 T6663 prep to,leading
R4709 T6665 T6667 poss its,degradation
R4710 T6521 T6520 amod similar,manner
R4711 T6666 T6667 amod continuous,degradation
R4712 T6667 T6664 pobj degradation,to
R4713 T6668 T6667 prep by,degradation
R4714 T6522 T6521 prep to,similar
R4715 T6669 T6670 det the,proteasome
R4716 T6670 T6668 pobj proteasome,by
R4717 T6671 T6663 punct .,leading
R4718 T6523 T6525 det the,pathway
R4719 T6672 T6673 compound Receptor,ligation
R4720 T6673 T6676 nsubjpass ligation,shown
R4721 T6674 T6676 aux has,shown
R4722 T6524 T6525 compound TNF,pathway
R4723 T6675 T6676 auxpass been,shown
R4724 T6676 T6676 ROOT shown,shown
R4725 T6677 T6680 preconj not,remove
R4726 T6525 T6522 pobj pathway,to
R4727 T6678 T6677 advmod only,not
R4728 T6679 T6680 aux to,remove
R4729 T6680 T6676 xcomp remove,shown
R4730 T6526 T6525 punct (,pathway
R4731 T6681 T6680 dobj TRAF3,remove
R4732 T6682 T6680 prep from,remove
R4733 T6683 T6684 det this,complex
R4734 T6527 T6525 appos Figure,pathway
R4735 T6684 T6682 pobj complex,from
R4736 T6685 T6680 prep by,remove
R4737 T6686 T6685 pcomp recruiting,by
R4738 T6528 T6527 nummod 1,Figure
R4739 T6687 T6686 dobj it,recruiting
R4740 T6688 T6686 prep to,recruiting
R4741 T6529 T6525 punct ),pathway
R4742 T6689 T6690 det the,receptor
R4743 T6690 T6688 pobj receptor,to
R4744 T6691 T6680 punct ",",remove
R4745 T6530 T6513 punct .,activate
R4746 T6692 T6680 cc but,remove
R4747 T6693 T6692 advmod also,but
R4748 T6694 T6695 aux to,attract
R4749 T6695 T6680 conj attract,remove
R4750 T6696 T6695 dobj TRAF2,attract
R4751 T6697 T6695 cc and,attract
R4752 T6531 T6534 det The,pathway
R4753 T6698 T6695 conj cIAP1/2,attract
R4754 T6699 T6698 punct ",",cIAP1/2
R4755 T6700 T6701 nsubj which,are
R4756 T6532 T6534 amod noncanonical,pathway
R4757 T6701 T6698 relcl are,cIAP1/2
R4758 T6702 T6701 acomp essential,are
R4759 T6703 T6702 prep for,essential
R4760 T6533 T6534 compound NF-κB,pathway
R4761 T6704 T6706 amod subsequent,degradation
R4762 T6705 T6706 nummod TRAF3,degradation
R4763 T6534 T6537 nsubjpass pathway,activated
R4764 T6706 T6703 pobj degradation,for
R4765 T6707 T6676 punct .,shown
R4766 T6708 T6709 predet All,this
R4767 T6535 T6537 aux can,activated
R4768 T6709 T6710 nsubj this,contributes
R4769 T6710 T6710 ROOT contributes,contributes
R4770 T6536 T6537 auxpass be,activated
R4771 T6711 T6710 prep to,contributes
R4772 T6712 T6711 pcomp releasing,to
R4773 T6713 T6712 dobj NIK,releasing
R4774 T6537 T6537 ROOT activated,activated
R4775 T6714 T6710 prep from,contributes
R4776 T6715 T6717 poss its,degradation
R4777 T6716 T6717 amod constitutive,degradation
R4778 T6538 T6537 agent by,activated
R4779 T6717 T6714 pobj degradation,from
R4780 T6718 T6710 punct ",",contributes
R4781 T6719 T6710 advcl resulting,contributes
R4782 T6733 T6710 punct .,contributes
R4783 T6720 T6719 prep in,resulting
R4784 T6721 T6722 compound NIK,accumulation
R4785 T6722 T6720 pobj accumulation,in
R4786 T6723 T6722 cc and,accumulation
R4787 T6724 T6725 nummod IKK1,phosphorylation
R4788 T6734 T6737 nsubjpass It,mentioned
R4789 T6725 T6728 compound phosphorylation,]
R4790 T6726 T6728 compound [,]
R4791 T6735 T6737 aux should,mentioned
R4792 T6727 T6728 compound "28,29",]
R4793 T6728 T6728 ROOT ],]
R4794 T6736 T6737 auxpass be,mentioned
R4795 T6729 T6730 punct (,Figure
R4796 T6730 T6728 appos Figure,]
R4797 T6731 T6730 nummod 2,Figure
R4798 T6732 T6730 punct ),Figure
R4799 T6737 T6737 ROOT mentioned,mentioned
R4800 T6738 T6746 mark that,mediate
R4801 T6739 T6746 nsubj CD40,mediate
R4802 T6830 T6828 pobj cells,in
R4803 T6831 T6833 nsubjpass TRAF6,required
R4804 T6740 T6739 punct ",",CD40
R4805 T6832 T6833 auxpass is,required
R4806 T6833 T6833 ROOT required,required
R4807 T6834 T6833 prep for,required
R4808 T6835 T6837 amod CD40-mediated,activation
R4809 T6741 T6743 nmod lymphotoxin,receptor
R4810 T6836 T6837 compound JNK,activation
R4811 T6837 T6834 pobj activation,for
R4812 T6742 T6743 compound β,receptor
R4813 T6838 T6837 cc and,activation
R4814 T6839 T6837 conj IL-6,activation
R4815 T6840 T6837 conj production,activation
R4816 T6743 T6739 appos receptor,CD40
R4817 T6841 T6833 punct ",",required
R4818 T6842 T6845 mark while,required
R4819 T6843 T6845 nsubjpass TRAF2,required
R4820 T6744 T6743 cc and,receptor
R4821 T6844 T6845 auxpass is,required
R4822 T6845 T6833 advcl required,required
R4823 T6846 T6845 prep for,required
R4824 T6745 T6743 conj RANK,receptor
R4825 T6847 T6846 pobj activation,for
R4826 T6848 T6847 prep of,activation
R4827 T6849 T6848 pobj NF-κB,of
R4828 T6746 T6737 ccomp mediate,mentioned
R4829 T6850 T6845 punct ",",required
R4830 T6851 T6833 cc and,required
R4831 T6747 T6748 det the,activation
R4832 T6852 T6853 nsubj TRAF3,serves
R4833 T6853 T6833 conj serves,required
R4834 T6854 T6853 prep as,serves
R4835 T6748 T6746 dobj activation,mediate
R4836 T6855 T6857 det a,regulator
R4837 T6856 T6857 amod negative,regulator
R4838 T6749 T6748 prep of,activation
R4839 T6857 T6854 pobj regulator,as
R4840 T6858 T6857 prep of,regulator
R4841 T6859 T6860 nsubj CD40,signalling
R4842 T6750 T6751 preconj both,canonical
R4843 T6860 T6858 pcomp signalling,of
R4844 T6861 T6863 compound [,]
R4845 T6751 T6756 amod canonical,pathways
R4846 T6862 T6863 compound "30,31",]
R4847 T6863 T6860 dobj ],signalling
R4848 T6864 T6853 punct .,serves
R4849 T6752 T6751 cc and,canonical
R4850 T6753 T6751 conj noncanonical,canonical
R4851 T6754 T6755 npadvmod NF-κB,signalling
R4852 T6755 T6756 amod signalling,pathways
R4853 T6756 T6749 pobj pathways,of
R4854 T6757 T6737 punct .,mentioned
R4855 T6758 T6787 prep Upon,leads
R4856 T6759 T6758 pobj binding,Upon
R4857 T6760 T6759 prep of,binding
R4858 T6761 T6762 poss their,ligand
R4859 T6762 T6760 pobj ligand,of
R4860 T6763 T6762 punct ",",ligand
R4861 T6764 T6762 appos CD40,ligand
R4862 T6765 T6764 cc and,CD40
R4863 T6766 T6767 compound RANK,interact
R4864 T6767 T6787 nsubj interact,leads
R4865 T6768 T6767 prep with,interact
R4866 T6769 T6771 amod several,members
R4867 T6770 T6771 compound TRAF,members
R4868 T6771 T6768 pobj members,with
R4869 T6772 T6771 punct ",",members
R4870 T6773 T6771 prep including,members
R4871 T6774 T6773 pobj TRAF1,including
R4872 T6775 T6774 punct ",",TRAF1
R4873 T6776 T6774 conj TRAF2,TRAF1
R4874 T6777 T6771 punct ",",members
R4875 T6778 T6771 appos TRAF3,members
R4876 T6779 T6778 punct ",",TRAF3
R4877 T6780 T6778 conj TRAF5,TRAF3
R4878 T6781 T6767 punct ",",interact
R4879 T6782 T6767 cc and,interact
R4880 T6783 T6767 conj TRAF6,interact
R4881 T6784 T6783 punct ",",TRAF6
R4882 T6785 T6783 cc and,TRAF6
R4883 T6786 T6787 nsubj this,leads
R4884 T6787 T6787 ROOT leads,leads
R4885 T6788 T6787 prep to,leads
R4886 T6789 T6790 det the,proteolysis
R4887 T6790 T6788 pobj proteolysis,to
R4888 T6791 T6790 prep of,proteolysis
R4889 T6792 T6793 det both,TRAF2
R4890 T6793 T6791 pobj TRAF2,of
R4891 T6794 T6793 cc and,TRAF2
R4892 T6795 T6793 conj TRAF3,TRAF2
R4893 T6796 T6790 punct ",",proteolysis
R4894 T6797 T6798 nsubj which,represents
R4895 T6798 T6790 relcl represents,proteolysis
R4896 T6799 T6801 det an,step
R4897 T6800 T6801 amod important,step
R4898 T6801 T6798 dobj step,represents
R4899 T6802 T6801 prep in,step
R4900 T6803 T6804 det the,activation
R4901 T6804 T6802 pobj activation,in
R4902 T6805 T6804 prep of,activation
R4904 T6806 T6808 det the,pathway
R4908 T6807 T6808 amod noncanonical,pathway
R4912 T6808 T6805 pobj pathway,of
R4914 T6809 T6810 mark as,described
R4917 T6810 T6798 advcl described,represents
R4918 T6811 T6810 advmod above,described
R4920 T6812 T6787 punct .,leads
R4921 T6813 T6815 amod Specific,molecules
R4923 T6814 T6815 compound TRAF,molecules
R4926 T6815 T6817 nsubjpass molecules,associated
R4929 T6816 T6817 auxpass are,associated
R4931 T6817 T6817 ROOT associated,associated
R4934 T6818 T6817 prep with,associated
R4938 T6819 T6818 pobj overlapping,with
R4941 T6820 T6819 cc and,overlapping
R4943 T6821 T6823 amod distinct,functions
R4948 T6822 T6823 amod CD40-mediated,functions
R4949 T6823 T6819 conj functions,overlapping
R4950 T6824 T6817 punct .,associated
R4951 T6825 T6833 prep For,required
R4953 T6826 T6825 pobj example,For
R4955 T6827 T6833 punct ",",required
R4957 T6828 T6833 prep in,required
R4958 T6829 T6830 compound B,cells
R5922 T8788 T8789 compound NF-κB,activation
R5923 T8789 T8790 nsubj activation,is
R5924 T8790 T8811 advcl is,is
R5925 T8791 T8792 advmod so,crucial
R5926 T8792 T8790 acomp crucial,is
R5927 T8793 T8792 prep to,crucial
R5928 T8794 T8796 amod many,processes
R5929 T8795 T8796 amod cellular,processes
R5930 T8796 T8793 pobj processes,to
R5931 T8797 T8811 punct ",",is
R5932 T8798 T8800 det a,regulation
R5933 T8799 T8800 amod tight,regulation
R5934 T8800 T8811 nsubj regulation,is
R5935 T8801 T8800 prep of,regulation
R5936 T8802 T8805 det the,pathway
R5937 T8803 T8805 nmod NF-κB,pathway
R5938 T8804 T8805 amod signalling,pathway
R5939 T8805 T8801 pobj pathway,of
R5940 T8806 T8805 cc and,pathway
R5941 T8807 T8808 det the,genes
R5942 T8808 T8805 conj genes,pathway
R5943 T8809 T8810 nsubj it,induces
R5944 T8810 T8808 relcl induces,genes
R5945 T8811 T8811 ROOT is,is
R5946 T8812 T8814 det an,requirement
R5947 T8813 T8814 amod absolute,requirement
R5948 T8814 T8811 attr requirement,is
R5949 T8815 T8816 aux to,fine-tune
R5950 T8816 T8814 acl fine-tune,requirement
R5951 T8817 T8819 det the,response
R5952 T8818 T8819 amod inflammatory,response
R5953 T8819 T8816 dobj response,fine-tune
R5954 T8820 T8811 punct .,is
R5955 T8821 T8827 advmod Moreover,is
R5956 T8822 T8827 punct ",",is
R5957 T8823 T8827 csubj terminating,is
R5958 T8824 T8826 det an,response
R5959 T8825 T8826 amod NF-κB,response
R5960 T8826 T8823 dobj response,terminating
R5961 T8827 T8827 ROOT is,is
R5962 T8828 T8827 acomp essential,is
R5963 T8829 T8830 aux to,prevent
R5964 T8830 T8827 xcomp prevent,is
R5965 T8831 T8833 amod persistent,activation
R5966 T8832 T8833 compound NF-κB,activation
R5967 T8833 T8830 dobj activation,prevent
R5968 T8834 T8836 nsubj that,lead
R5969 T8835 T8836 aux may,lead
R5970 T8836 T8833 relcl lead,activation
R5971 T8837 T8836 prep to,lead
R5972 T8838 T8839 amod chronic,inflammation
R5973 T8839 T8837 pobj inflammation,to
R5974 T8840 T8839 cc and/or,inflammation
R5975 T8841 T8839 conj tumorigenesis,inflammation
R5976 T8842 T8827 punct .,is
R5977 T8843 T8844 aux To,achieve
R5978 T8844 T8848 advcl achieve,employ
R5979 T8845 T8844 dobj this,achieve
R5980 T8846 T8848 punct ",",employ
R5981 T8847 T8848 nsubj cells,employ
R5982 T8848 T8848 ROOT employ,employ
R5983 T8849 T8850 amod different,mechanisms
R5984 T8850 T8848 dobj mechanisms,employ
R5985 T8851 T8850 punct ",",mechanisms
R5986 T8852 T8850 prep including,mechanisms
R5987 T8853 T8854 det the,expression
R5988 T8854 T8852 pobj expression,including
R5989 T8855 T8854 prep of,expression
R5990 T8856 T8857 amod inhibitory,proteins
R5991 T8857 T8855 pobj proteins,of
R5992 T8858 T8861 nsubj that,signalling
R5993 T8859 T8861 dep downregulate,signalling
R5994 T8860 T8861 amod NF-κB,signalling
R5995 T8861 T8854 relcl signalling,expression
R5996 T8862 T8864 nmod [,]
R5997 T8863 T8864 nummod 32,]
R5998 T8864 T8861 dobj ],signalling
R5999 T8865 T8848 punct .,employ
R6000 T8866 T8868 advmod Below,give
R6001 T8867 T8868 nsubj we,give
R6002 T8868 T8868 ROOT give,give
R6003 T8869 T8870 det an,overview
R6004 T8870 T8868 dobj overview,give
R6005 T8871 T8870 prep of,overview
R6006 T8872 T8873 det a,number
R6007 T8873 T8871 pobj number,of
R6008 T8874 T8873 prep of,number
R6009 T8875 T8874 pobj proteins,of
R6010 T8876 T8878 nsubjpass that,involved
R6011 T8877 T8878 auxpass are,involved
R6012 T8878 T8875 relcl involved,proteins
R6013 T8879 T8878 prep in,involved
R6014 T8880 T8881 det the,dampening
R6015 T8881 T8879 pobj dampening,in
R6016 T8882 T8881 cc or,dampening
R6017 T8883 T8881 conj termination,dampening
R6018 T8884 T8883 prep of,termination
R6019 T8885 T8887 det the,response
R6020 T8886 T8887 compound NF-κB,response
R6021 T8887 T8884 pobj response,of
R6022 T8888 T8870 punct ",",overview
R6023 T8889 T8900 nsubj some,acting
R6024 T8890 T8889 prep of,some
R6025 T8891 T8890 pobj them,of
R6026 T8892 T8889 prep under,some
R6027 T8893 T8894 det the,control
R6028 T8894 T8892 pobj control,under
R6029 T8895 T8894 prep of,control
R6030 T8896 T8895 pobj NF-κB,of
R6031 T8897 T8896 dobj itself,NF-κB
R6032 T8898 T8896 cc and,NF-κB
R6033 T8899 T8900 advmod thus,acting
R6034 T8900 T8870 acl acting,overview
R6035 T8901 T8900 prep in,acting
R6036 T8902 T8905 det a,loop
R6037 T8903 T8905 amod negative,loop
R6038 T8904 T8905 compound feedback,loop
R6039 T8905 T8901 pobj loop,in
R6040 T8906 T8868 punct .,give
R6041 T8907 T8911 prep In,discuss
R6042 T8908 T8907 pobj addition,In
R6043 T8909 T8911 punct ",",discuss
R6044 T8910 T8911 nsubj we,discuss
R6045 T8911 T8911 ROOT discuss,discuss
R6046 T8912 T8914 det the,role
R6047 T8913 T8914 amod potential,role
R6048 T8914 T8911 dobj role,discuss
R6049 T8915 T8914 prep of,role
R6050 T8916 T8919 det these,factors
R6051 T8917 T8919 amod NF-κB,factors
R6052 T8918 T8919 compound inhibitory,factors
R6053 T8919 T8915 pobj factors,of
R6054 T8920 T8914 prep in,role
R6055 T8921 T8922 det the,immunopathology
R6056 T8922 T8920 pobj immunopathology,in
R6057 T8923 T8922 prep of,immunopathology
R6058 T8924 T8923 pobj RA,of
R6059 T8925 T8911 punct .,discuss
R6060 T8926 T8928 amod Several,proteins
R6061 T8927 T8928 amod other,proteins
R6062 T8928 T8950 nsubjpass proteins,described
R6063 T8929 T8928 acl involved,proteins
R6064 T8930 T8929 prep in,involved
R6065 T8931 T8933 det the,regulation
R6066 T8932 T8933 amod negative,regulation
R6067 T8933 T8930 pobj regulation,in
R6068 T8934 T8933 prep of,regulation
R6069 T8935 T8937 amod NF-κB-dependent,responses
R6070 T8936 T8937 amod inflammatory,responses
R6071 T8937 T8934 pobj responses,of
R6072 T8938 T8937 punct ",",responses
R6073 T8939 T8940 amod such,as
R6074 T8940 T8937 prep as,responses
R6075 T8941 T8940 pobj MyD88s,as
R6076 T8942 T8941 punct ",",MyD88s
R6077 T8943 T8941 conj IRAK-M,MyD88s
R6078 T8944 T8943 punct ",",IRAK-M
R6079 T8945 T8943 cc and,IRAK-M
R6080 T8946 T8943 conj TOLLIP,IRAK-M
R6081 T8947 T8950 punct ",",described
R6082 T8948 T8950 aux have,described
R6083 T8949 T8950 auxpass been,described
R6084 T8950 T8950 ROOT described,described
R6085 T8951 T8950 punct (,described
R6086 T8952 T8950 advcl reviewed,described
R6087 T8953 T8952 prep in,reviewed
R6088 T8954 T8953 pobj [,in
R6089 T8955 T8956 nummod 33,]
R6090 T8956 T8954 appos ],[
R6091 T8957 T8954 punct ),[
R6092 T8958 T8950 punct .,described
R6093 T8959 T8960 det These,proteins
R6094 T8960 T8963 nsubjpass proteins,discussed
R6095 T8961 T8963 auxpass are,discussed
R6096 T8962 T8963 neg not,discussed
R6097 T8963 T8963 ROOT discussed,discussed
R6098 T8964 T8963 advmod here,discussed
R6099 T8965 T8963 punct ",",discussed
R6100 T8966 T8963 prep since,discussed
R6101 T8967 T8968 det a,link
R6102 T8968 T8966 pobj link,since
R6103 T8969 T8968 prep with,link
R6104 T8970 T8971 compound RA,pathology
R6105 T8971 T8969 pobj pathology,with
R6106 T8972 T8978 advcl has,is
R6107 T8973 T8976 neg not,"reported. Although"
R6108 T8974 T8976 advmod yet,"reported. Although"
R6109 T8975 T8976 auxpass been,"reported. Although"
R6110 T8976 T8977 compound "reported. Although",IKK1
R6111 T8977 T8978 nsubj IKK1,is
R6112 T8978 T8991 advcl is,mentioned
R6113 T8979 T8981 det a,component
R6114 T8980 T8981 amod critical,component
R6115 T8981 T8978 attr component,is
R6116 T8982 T8981 prep of,component
R6117 T8983 T8986 det the,pathway
R6118 T8984 T8986 amod non-canonical,pathway
R6119 T8985 T8986 compound NF-κB,pathway
R6120 T8986 T8982 pobj pathway,of
R6121 T8987 T8991 punct ",",mentioned
R6122 T8988 T8991 nsubjpass it,mentioned
R6123 T8989 T8991 aux should,mentioned
R6124 T8990 T8991 auxpass be,mentioned
R6125 T8991 T8963 advcl mentioned,discussed
R6126 T8992 T8996 mark that,plays
R6127 T8993 T8994 det this,kinase
R6128 T8994 T8996 nsubj kinase,plays
R6129 T8995 T8996 advmod also,plays
R6130 T8996 T8991 ccomp plays,mentioned
R6131 T8997 T8999 det a,role
R6132 T8998 T8999 amod prominent,role
R6133 T8999 T8996 dobj role,plays
R6134 T9000 T8999 prep in,role
R6135 T9001 T9003 det the,regulation
R6136 T9002 T9003 amod negative,regulation
R6137 T9003 T9000 pobj regulation,in
R6138 T9004 T9003 prep of,regulation
R6139 T9005 T9006 preconj both,canonical
R6140 T9006 T9010 amod canonical,pathways
R6141 T9007 T9006 cc and,canonical
R6142 T9008 T9006 conj noncanonical,canonical
R6143 T9009 T9010 compound NF-κB,pathways
R6144 T9010 T9004 pobj pathways,of
R6145 T9011 T8963 punct .,discussed
R6146 T9012 T9023 nsubj Macrophages,increased
R6147 T9013 T9012 prep from,Macrophages
R6148 T9014 T9015 amod IKK1-deficient,mice
R6149 T9015 T9013 pobj mice,from
R6150 T9016 T9015 cc or,mice
R6151 T9017 T9018 compound knockin,mice
R6152 T9018 T9015 conj mice,mice
R6153 T9019 T9012 acl expressing,Macrophages
R6154 T9020 T9022 amod inactive,show
R6155 T9021 T9022 compound IKK1,show
R6156 T9022 T9019 dobj show,expressing
R6157 T9023 T9023 ROOT increased,increased
R6158 T9024 T9023 dobj production,increased
R6159 T9025 T9024 prep of,production
R6160 T9026 T9027 amod proinflammatory,cytokines
R6161 T9027 T9025 pobj cytokines,of
R6162 T9028 T9023 prep as,increased
R6163 T9029 T9030 det a,result
R6164 T9030 T9028 pobj result,as
R6165 T9031 T9030 prep of,result
R6166 T9032 T9034 amod enhanced,activation
R6167 T9033 T9034 compound IKK2,activation
R6168 T9034 T9031 pobj activation,of
R6169 T9035 T9034 cc and,activation
R6170 T9036 T9037 compound IκBα,degradation
R6171 T9037 T9034 conj degradation,activation
R6172 T9038 T9040 nmod [,]
R6173 T9039 T9040 nummod 34,]
R6174 T9040 T9037 appos ],degradation
R6175 T9041 T9023 punct .,increased
R6176 T9042 T9046 nsubjpass IKK1,shown
R6177 T9043 T9046 aux has,shown
R6178 T9044 T9046 advmod also,shown
R6179 T9045 T9046 auxpass been,shown
R6180 T9046 T9046 ROOT shown,shown
R6181 T9047 T9048 aux to,inhibit
R6182 T9048 T9046 advcl inhibit,shown
R6183 T9049 T9050 amod nuclear,NF-κB
R6184 T9050 T9048 dobj NF-κB,inhibit
R6185 T9051 T9048 cc and,inhibit
R6186 T9052 T9053 aux to,downregulate
R6187 T9053 T9048 conj downregulate,inhibit
R6188 T9054 T9055 compound proinflammatory,signalling
R6189 T9055 T9053 dobj signalling,downregulate
R6190 T9056 T9053 prep by,downregulate
R6191 T9057 T9056 pcomp phosphorylating,by
R6192 T9058 T9059 compound STAT1,[
R6193 T9059 T9057 dobj [,phosphorylating
R6194 T9060 T9061 nummod 35,]
R6195 T9061 T9059 appos ],[
R6196 T9062 T9046 punct .,shown
R6197 T9063 T9069 advmod Interestingly,demonstrated
R6198 T9064 T9069 punct ",",demonstrated
R6199 T9065 T9067 det a,study
R6200 T9066 T9067 amod recent,study
R6201 T9067 T9069 nsubj study,demonstrated
R6202 T9068 T9069 aux has,demonstrated
R6203 T9069 T9069 ROOT demonstrated,demonstrated
R6204 T9070 T9069 dobj that,demonstrated
R6205 T9071 T9072 nummod IKK1,phosphorylates
R6206 T9072 T9070 nsubj phosphorylates,that
R6207 T9073 T9072 appos NIK,phosphorylates
R6208 T9074 T9073 prep in,NIK
R6209 T9075 T9077 amod negative,regulation
R6210 T9076 T9077 compound feedback,regulation
R6211 T9077 T9074 pobj regulation,in
R6212 T9078 T9077 prep of,regulation
R6213 T9079 T9082 det the,pathway
R6214 T9080 T9082 amod noncanonical,pathway
R6215 T9081 T9082 compound NF-κB,pathway
R6216 T9082 T9078 pobj pathway,of
R6217 T9083 T9085 nmod [,]
R6218 T9084 T9085 nummod 36,]
R6219 T9085 T9082 appos ],pathway
R6220 T9086 T9072 punct ",",phosphorylates
R6221 T9087 T9072 acl supporting,phosphorylates
R6222 T9088 T9089 det the,idea
R6223 T9089 T9087 dobj idea,supporting
R6224 T9090 T9092 mark that,plays
R6225 T9091 T9092 nsubj IKK1,plays
R6226 T9092 T9089 acl plays,idea
R6227 T9093 T9094 amod important,roles
R6228 T9094 T9092 dobj roles,plays
R6229 T9095 T9092 prep in,plays
R6230 T9096 T9095 pcomp terminating,in
R6231 T9097 T9098 preconj both,canonical
R6232 T9098 T9102 amod canonical,pathways
R6233 T9099 T9098 cc and,canonical
R6234 T9100 T9098 conj noncanonical,canonical
R6235 T9101 T9102 compound NF-κB,pathways
R6236 T9102 T9096 dobj pathways,terminating
R6237 T9103 T9102 prep with,pathways
R6238 T9104 T9105 amod possible,implications
R6239 T9105 T9103 pobj implications,with
R6240 T9106 T9105 prep for,implications
R6241 T9107 T9109 amod chronic,diseases
R6242 T9108 T9109 amod inflammatory,diseases
R6243 T9109 T9106 pobj diseases,for
R6244 T9110 T9109 prep like,diseases
R6245 T9111 T9110 pobj RA,like
R6246 T9112 T9069 punct .,demonstrated
R7236 T10863 T10864 advmod also,known
R7237 T10864 T10861 acl known,A20
R7238 T10865 T10864 prep as,known
R7239 T10866 T10865 pobj TNFAIP3,as
R7240 T10867 T10861 punct ),A20
R7241 T10868 T10868 ROOT is,is
R7242 T10869 T10871 det a,protein
R7243 T10870 T10871 amod ubiquitin-editing,protein
R7244 T10871 T10868 attr protein,is
R7245 T10872 T10874 nsubj that,regulates
R7246 T10873 T10874 advmod negatively,regulates
R7247 T10874 T10871 relcl regulates,protein
R7248 T10875 T10877 amod NF-κB-dependent,expression
R7249 T10876 T10877 compound gene,expression
R7250 T10877 T10874 dobj expression,regulates
R7251 T10878 T10874 prep in,regulates
R7252 T10879 T10878 pobj response,in
R7253 T10880 T10879 prep to,response
R7254 T10881 T10883 amod different,stimuli
R7255 T10882 T10883 amod immune-activating,stimuli
R7256 T10883 T10880 pobj stimuli,to
R7257 T10884 T10883 punct ",",stimuli
R7258 T10885 T10883 prep including,stimuli
R7259 T10886 T10885 pobj TNF,including
R7260 T10887 T10886 punct ",",TNF
R7261 T10888 T10886 conj IL-1,TNF
R7262 T10889 T10888 cc and,IL-1
R7263 T10890 T10888 conj antigens,IL-1
R7264 T10891 T10883 punct ",",stimuli
R7265 T10892 T10883 cc and,stimuli
R7266 T10893 T10894 det the,triggering
R7267 T10894 T10883 conj triggering,stimuli
R7268 T10895 T10894 prep of,triggering
R7269 T10896 T10895 pobj TLRs,of
R7270 T10897 T10896 cc and,TLRs
R7271 T10898 T10903 det the,receptor
R7272 T10899 T10901 nmod nucleotide-binding,domain-containing
R7273 T10900 T10901 compound oligomerisation,domain-containing
R7274 T10901 T10903 nmod domain-containing,receptor
R7275 T10902 T10903 nummod 2,receptor
R7276 T10903 T10896 conj receptor,TLRs
R7277 T10904 T10905 punct (,reviewed
R7278 T10905 T10883 acl reviewed,stimuli
R7279 T10906 T10905 prep in,reviewed
R7280 T10907 T10906 pobj [,in
R7281 T10908 T10909 nummod 37,]
R7282 T10909 T10907 appos ],[
R7283 T10910 T10907 punct ),[
R7284 T10911 T10868 punct .,is
R7285 T10912 T10914 nsubjpass A20,believed
R7286 T10913 T10914 auxpass is,believed
R7287 T10914 T10914 ROOT believed,believed
R7288 T10915 T10916 aux to,inhibit
R7289 T10916 T10914 xcomp inhibit,believed
R7290 T10917 T10918 amod NF-κB,function
R7291 T10918 T10916 dobj function,inhibit
R7292 T10919 T10916 prep by,inhibit
R7293 T10920 T10919 pcomp deubiquitinating,by
R7294 T10921 T10924 amod specific,molecules
R7295 T10922 T10923 npadvmod NF-κB,signalling
R7296 T10923 T10924 amod signalling,molecules
R7297 T10924 T10920 dobj molecules,deubiquitinating
R7298 T10925 T10924 punct ",",molecules
R7299 T10926 T10927 amod such,as
R7300 T10927 T10924 prep as,molecules
R7301 T10928 T10927 pobj RIP1,as
R7302 T10929 T10928 punct ",",RIP1
R7303 T10930 T10928 conj RIP2,RIP1
R7304 T10931 T10930 punct ",",RIP2
R7305 T10932 T10930 conj TRAF6,RIP2
R7306 T10933 T10932 cc and,TRAF6
R7307 T10934 T10932 conj MALT1,TRAF6
R7308 T10935 T10928 punct ",",RIP1
R7309 T10936 T10937 nsubj which,disrupts
R7310 T10937 T10928 relcl disrupts,RIP1
R7311 T10938 T10940 amod specific,interactions
R7312 T10939 T10940 amod protein-protein,interactions
R7313 T10940 T10937 dobj interactions,disrupts
R7314 T10941 T10943 nmod [,]
R7315 T10942 T10943 nummod 38-41,]
R7316 T10943 T10940 nmod ],interactions
R7317 T10944 T10945 punct (,Figure
R7318 T10945 T10943 appos Figure,]
R7319 T10946 T10945 nummod 1,Figure
R7320 T10947 T10943 punct ),]
R7321 T10948 T10914 punct .,believed
R7322 T10949 T10977 advmod Recently,described
R7323 T10950 T10977 punct ",",described
R7324 T10951 T10952 det the,disruption
R7325 T10952 T10977 nsubjpass disruption,described
R7326 T10953 T10952 prep of,disruption
R7327 T10954 T10953 pobj interactions,of
R7328 T10955 T10952 prep between,disruption
R7329 T10956 T10959 nummod E2,enzymes
R7330 T10957 T10959 nmod ubiquitin,enzymes
R7331 T10958 T10959 amod conjugating,enzymes
R7332 T10959 T10955 pobj enzymes,between
R7333 T10960 T10959 punct (,enzymes
R7334 T10961 T10977 nsubjpass Ubc13,described
R7335 T10962 T10961 cc and,Ubc13
R7336 T10963 T10961 conj Ubc5hc,Ubc13
R7337 T10964 T10963 punct ),Ubc5hc
R7338 T10965 T10961 cc and,Ubc13
R7339 T10966 T10968 nummod E3,ligases
R7340 T10967 T10968 compound ubiquitin,ligases
R7341 T10968 T10961 conj ligases,Ubc13
R7342 T10969 T10968 punct (,ligases
R7343 T10970 T10968 appos TRAF6,ligases
R7344 T10971 T10970 punct ",",TRAF6
R7345 T10972 T10970 conj TRAF2,TRAF6
R7346 T10973 T10972 cc and,TRAF2
R7347 T10974 T10972 conj cIAP1/2,TRAF2
R7348 T10975 T10968 punct ),ligases
R7349 T10976 T10977 auxpass were,described
R7350 T10977 T10977 ROOT described,described
R7351 T10978 T10977 prep as,described
R7352 T10979 T10981 det another,mechanism
R7353 T10980 T10981 amod important,mechanism
R7354 T10981 T10978 pobj mechanism,as
R7355 T10982 T10981 acl used,mechanism
R7356 T10983 T10982 agent by,used
R7357 T10984 T10983 pobj A20,by
R7358 T10985 T10981 prep to,mechanism
R7359 T10986 T10985 pobj downregulate,to
R7360 T10987 T10988 npadvmod NF-κB,signalling
R7361 T10988 T10986 amod signalling,downregulate
R7362 T10989 T10991 nmod [,]
R7363 T10990 T10991 nummod 42,]
R7364 T10991 T10988 dobj ],signalling
R7365 T10992 T10977 punct .,described
R7366 T10993 T10994 det The,association
R7367 T10994 T11000 nsubj association,requires
R7368 T10995 T10994 prep of,association
R7369 T10996 T10995 pobj A20,of
R7370 T10997 T10994 prep with,association
R7371 T10998 T10999 poss its,targets
R7372 T10999 T10997 pobj targets,with
R7373 T11000 T11000 ROOT requires,requires
R7374 T11001 T11004 amod specific,proteins
R7375 T11002 T11004 amod ubiquitin-binding,proteins
R7376 T11003 T11004 compound adaptor,proteins
R7377 T11004 T11000 dobj proteins,requires
R7378 T11005 T11004 punct ",",proteins
R7379 T11006 T11004 prep including,proteins
R7380 T11007 T11008 amod A20-binding,inhibitor
R7381 T11008 T11006 pobj inhibitor,including
R7382 T11009 T11008 prep of,inhibitor
R7383 T11010 T11009 pobj NF-κB,of
R7384 T11011 T11010 punct (,NF-κB
R7385 T11012 T11010 appos ABIN,NF-κB
R7386 T11013 T11010 punct ),NF-κB
R7387 T11014 T11010 nummod 1,NF-κB
R7388 T11015 T11008 cc and,inhibitor
R7389 T11016 T11017 amod Tax1-binding,protein
R7390 T11017 T11008 conj protein,inhibitor
R7391 T11018 T11019 nummod 1,[
R7392 T11019 T11021 compound [,]
R7393 T11020 T11021 compound 43-46,]
R7394 T11021 T11004 appos ],proteins
R7395 T11022 T11000 punct .,requires
R7396 T11023 T11033 advmod Next,is
R7397 T11024 T11023 prep to,Next
R7398 T11025 T11026 poss its,role
R7399 T11026 T11024 pobj role,to
R7400 T11027 T11026 prep in,role
R7401 T11028 T11027 pcomp suppressing,in
R7402 T11029 T11030 amod NF-κB,activation
R7403 T11030 T11028 dobj activation,suppressing
R7404 T11031 T11033 punct ",",is
R7405 T11032 T11033 nsubj A20,is
R7406 T11033 T11033 ROOT is,is
R7407 T11034 T11033 advmod also,is
R7408 T11035 T11037 det a,inhibitor
R7409 T11036 T11037 amod strong,inhibitor
R7410 T11037 T11033 attr inhibitor,is
R7411 T11038 T11037 prep of,inhibitor
R7412 T11039 T11038 pobj apoptosis,of
R7413 T11040 T11037 punct ",",inhibitor
R7414 T11041 T11042 advmod at,least
R7415 T11042 T11043 advmod least,in
R7416 T11043 T11037 prep in,inhibitor
R7417 T11044 T11046 det some,types
R7418 T11045 T11046 compound cell,types
R7419 T11046 T11043 pobj types,in
R7420 T11047 T11033 punct .,is
R7421 T11048 T11049 det The,mechanisms
R7422 T11049 T11059 nsubj mechanisms,are
R7423 T11050 T11053 prep by,regulates
R7424 T11051 T11050 pobj which,by
R7425 T11052 T11053 nsubj A20,regulates
R7426 T11053 T11049 relcl regulates,mechanisms
R7427 T11054 T11055 amod apoptotic,signalling
R7428 T11055 T11053 dobj signalling,regulates
R7429 T11056 T11053 punct ",",regulates
R7430 T11057 T11059 advmod however,are
R7431 T11058 T11059 punct ",",are
R7432 T11059 T11059 ROOT are,are
R7433 T11060 T11059 advmod still,are
R7434 T11061 T11059 acomp elusive,are
R7435 T11062 T11059 punct .,are
R7436 T11063 T11064 amod A20-deficient,mice
R7437 T11064 T11066 nsubj mice,develop
R7438 T11065 T11066 advmod spontaneously,develop
R7439 T11066 T11066 ROOT develop,develop
R7440 T11067 T11068 amod multiorgan,inflammation
R7441 T11068 T11066 dobj inflammation,develop
R7442 T11069 T11068 cc and,inflammation
R7443 T11070 T11068 conj cachexia,inflammation
R7444 T11071 T11070 cc and,cachexia
R7445 T11072 T11066 conj die,develop
R7446 T11073 T11072 prep within,die
R7447 T11074 T11075 nummod 2,weeks
R7448 T11075 T11073 pobj weeks,within
R7449 T11076 T11075 prep of,weeks
R7450 T11077 T11076 pobj birth,of
R7451 T11078 T11072 punct ",",die
R7452 T11079 T11072 advcl illustrating,die
R7453 T11080 T11083 det the,function
R7454 T11081 T11083 amod potent,function
R7455 T11082 T11083 amod anti-inflammatory,function
R7456 T11083 T11079 dobj function,illustrating
R7457 T11084 T11083 prep of,function
R7458 T11085 T11086 det this,molecule
R7459 T11086 T11084 pobj molecule,of
R7460 T11087 T11089 nmod [,]
R7461 T11088 T11089 nummod 46,]
R7462 T11089 T11083 appos ],function
R7463 T11090 T11066 punct .,develop
R7464 T11091 T11092 amod A20-deficient,cells
R7465 T11092 T11093 nsubj cells,are
R7466 T11093 T11093 ROOT are,are
R7467 T11094 T11093 advmod also,are
R7468 T11095 T11096 advmod more,susceptible
R7469 T11096 T11093 acomp susceptible,are
R7470 T11097 T11096 prep to,susceptible
R7471 T11098 T11099 amod TNF-mediated,apoptosis
R7472 T11099 T11097 pobj apoptosis,to
R7473 T11100 T11093 punct ",",are
R7474 T11101 T11093 advcl confirming,are
R7475 T11102 T11103 poss its,role
R7476 T11103 T11101 dobj role,confirming
R7477 T11104 T11103 prep as,role
R7478 T11105 T11107 det an,protein
R7479 T11106 T11107 amod antiapoptotic,protein
R7480 T11107 T11104 pobj protein,as
R7481 T11108 T11093 punct .,are
R7482 T11109 T11111 nsubj We,showed
R7483 T11110 T11111 advmod recently,showed
R7484 T11111 T11111 ROOT showed,showed
R7485 T11112 T11121 mark that,exhibit
R7486 T11113 T11121 nsubj mice,exhibit
R7487 T11114 T11115 advmod specifically,lacking
R7488 T11115 T11113 acl lacking,mice
R7489 T11116 T11115 dobj A20,lacking
R7490 T11117 T11115 prep in,lacking
R7491 T11118 T11120 amod intestinal,cells
R7492 T11119 T11120 amod epithelial,cells
R7493 T11120 T11117 pobj cells,in
R7494 T11121 T11111 ccomp exhibit,showed
R7495 T11122 T11123 amod increased,susceptibility
R7496 T11123 T11121 dobj susceptibility,exhibit
R7497 T11124 T11121 prep to,exhibit
R7498 T11125 T11126 amod experimental,colitis
R7499 T11126 T11124 pobj colitis,to
R7500 T11127 T11126 amod due,colitis
R7501 T11128 T11127 pcomp to,due
R7502 T11129 T11130 det the,hypersensitivity
R7503 T11130 T11128 pobj hypersensitivity,to
R7504 T11131 T11130 prep of,hypersensitivity
R7505 T11132 T11135 poss their,cells
R7506 T11133 T11135 amod intestinal,cells
R7507 T11134 T11135 amod epithelial,cells
R7508 T11135 T11131 pobj cells,of
R7509 T11136 T11127 pcomp to,due
R7510 T11137 T11138 amod TNF-induced,apoptosis
R7511 T11138 T11136 pobj apoptosis,to
R7512 T11139 T11121 punct ",",exhibit
R7513 T11140 T11121 advcl confirming,exhibit
R7514 T11141 T11140 dobj A20,confirming
R7515 T11142 T11140 prep as,confirming
R7516 T11143 T11146 det a,protein
R7517 T11144 T11146 amod major,protein
R7518 T11145 T11146 amod antiapoptotic,protein
R7519 T11146 T11142 pobj protein,as
R7520 T11147 T11146 prep in,protein
R7521 T11148 T11151 det the,[
R7522 T11149 T11150 amod intestinal,epithelium
R7523 T11150 T11151 compound epithelium,[
R7524 T11151 T11147 pobj [,in
R7525 T11152 T11153 nummod 47,]
R7526 T11153 T11151 appos ],[
R7527 T11154 T11111 punct .,showed
R7528 T11155 T11157 nummod Two,studies
R7529 T11156 T11157 amod independent,studies
R7530 T11157 T11158 nsubj studies,showed
R7531 T11158 T11158 ROOT showed,showed
R7532 T11159 T11166 mark that,develop
R7533 T11160 T11166 nsubj mice,develop
R7534 T11161 T11160 acl lacking,mice
R7535 T11162 T11161 dobj A20,lacking
R7536 T11163 T11161 prep in,lacking
R7537 T11164 T11165 compound B,cells
R7538 T11165 T11163 pobj cells,in
R7539 T11166 T11158 ccomp develop,showed
R7540 T11167 T11166 dobj autoimmunity,develop
R7541 T11168 T11166 prep due,develop
R7542 T11169 T11168 pcomp to,due
R7543 T11170 T11172 amod hyperactive,responses
R7544 T11171 T11172 compound NF-κB,responses
R7545 T11172 T11169 pobj responses,to
R7546 T11173 T11172 prep in,responses
R7547 T11174 T11175 compound B,cells
R7548 T11175 T11173 pobj cells,in
R7549 T11176 T11175 acl leading,cells
R7550 T11177 T11176 prep to,leading
R7551 T11178 T11180 amod unrestricted,survival
R7552 T11179 T11180 compound B-cell,survival
R7553 T11180 T11177 pobj survival,to
R7554 T11181 T11183 nmod [,]
R7555 T11182 T11183 nummod "48,49",]
R7556 T11183 T11168 pobj ],due
R7557 T11184 T11158 punct .,showed
R7558 T11185 T11186 nummod A20,expression
R7559 T11186 T11189 nsubjpass expression,observed
R7560 T11187 T11189 aux has,observed
R7561 T11188 T11189 auxpass been,observed
R7562 T11189 T11189 ROOT observed,observed
R7563 T11190 T11189 prep in,observed
R7564 T11191 T11193 amod several,types
R7565 T11192 T11193 compound cell,types
R7566 T11193 T11190 pobj types,in
R7567 T11194 T11195 nsubj that,play
R7568 T11195 T11193 relcl play,types
R7569 T11196 T11197 amod important,roles
R7570 T11197 T11195 dobj roles,play
R7571 T11198 T11195 prep in,play
R7572 T11199 T11200 det the,pathophysiology
R7573 T11200 T11198 pobj pathophysiology,in
R7574 T11201 T11200 prep of,pathophysiology
R7575 T11202 T11201 pobj RA,of
R7576 T11203 T11195 punct ",",play
R7577 T11204 T11205 amod such,as
R7578 T11205 T11193 prep as,types
R7579 T11206 T11205 pobj fibroblasts,as
R7580 T11207 T11206 punct ",",fibroblasts
R7581 T11208 T11206 conj synoviocytes,fibroblasts
R7582 T11209 T11208 cc and,synoviocytes
R7583 T11210 T11208 conj lymphocytes,synoviocytes
R7584 T11211 T11189 punct .,observed
R7585 T11212 T11216 advmod Interestingly,is
R7586 T11213 T11216 punct ",",is
R7587 T11214 T11215 compound A20,expression
R7588 T11215 T11216 nsubj expression,is
R7589 T11216 T11216 ROOT is,is
R7590 T11217 T11218 nsubjpass itself,regulated
R7591 T11218 T11216 ccomp regulated,is
R7592 T11219 T11218 agent by,regulated
R7593 T11220 T11221 compound NF-κB,[
R7594 T11221 T11223 nmod [,]
R7595 T11222 T11223 nummod 50,]
R7596 T11223 T11219 pobj ],by
R7597 T11224 T11216 punct ",",is
R7598 T11225 T11216 advcl implicating,is
R7599 T11226 T11225 dobj A20,implicating
R7600 T11227 T11225 prep in,implicating
R7601 T11228 T11231 det the,regulation
R7602 T11229 T11231 amod negative,regulation
R7603 T11230 T11231 compound feedback,regulation
R7604 T11231 T11227 pobj regulation,in
R7605 T11232 T11231 prep of,regulation
R7606 T11233 T11234 amod NF-κB,signalling
R7607 T11234 T11232 pobj signalling,of
R7608 T11235 T11216 punct .,is
R7609 T11236 T11245 advmod Recently,shown
R7610 T11237 T11245 punct ",",shown
R7611 T11238 T11239 amod intra-articular,injection
R7612 T11239 T11245 nsubjpass injection,shown
R7613 T11240 T11239 prep of,injection
R7614 T11241 T11243 det an,adenovirus
R7615 T11242 T11243 amod A20-expressing,adenovirus
R7616 T11243 T11240 pobj adenovirus,of
R7617 T11244 T11245 auxpass was,shown
R7618 T11245 T11245 ROOT shown,shown
R7619 T11246 T11247 aux to,reduce
R7620 T11247 T11245 xcomp reduce,shown
R7621 T11248 T11249 det the,severity
R7622 T11249 T11247 dobj severity,reduce
R7623 T11250 T11249 prep of,severity
R7624 T11251 T11252 amod synovial,inflammation
R7625 T11252 T11250 pobj inflammation,of
R7626 T11253 T11252 cc and,inflammation
R7627 T11254 T11255 amod joint,destruction
R7628 T11255 T11252 conj destruction,inflammation
R7629 T11256 T11247 prep in,reduce
R7630 T11257 T11259 det a,model
R7631 T11258 T11259 compound mouse,model
R7632 T11259 T11256 pobj model,in
R7633 T11260 T11259 prep of,model
R7634 T11261 T11262 amod collagen-induced,arthritis
R7635 T11262 T11260 pobj arthritis,of
R7636 T11263 T11247 punct ",",reduce
R7637 T11264 T11265 advmod even,in
R7638 T11265 T11247 prep in,reduce
R7639 T11266 T11267 amod untreated,joints
R7640 T11267 T11265 pobj joints,in
R7641 T11268 T11247 punct ",",reduce
R7642 T11269 T11247 prep in,reduce
R7643 T11270 T11275 preconj both,setting
R7644 T11271 T11275 det a,setting
R7645 T11272 T11275 nmod prophylactic,setting
R7646 T11273 T11272 cc and,prophylactic
R7647 T11274 T11275 amod therapeutic,setting
R7648 T11275 T11269 pobj setting,in
R7649 T11276 T11245 punct .,shown
R7650 T11277 T11278 nummod A20,expression
R7651 T11278 T11283 nsubjpass expression,associated
R7652 T11279 T11278 prep in,expression
R7653 T11280 T11281 amod synovial,tissue
R7654 T11281 T11279 pobj tissue,in
R7655 T11282 T11283 auxpass was,associated
R7656 T11283 T11283 ROOT associated,associated
R7657 T11284 T11283 prep with,associated
R7658 T11285 T11284 pobj inhibition,with
R7659 T11286 T11285 prep of,inhibition
R7660 T11287 T11288 amod NF-κB,activity
R7661 T11288 T11286 pobj activity,of
R7662 T11289 T11283 cc and,associated
R7663 T11290 T11291 amod decreased,levels
R7664 T11291 T11283 conj levels,associated
R7665 T11292 T11291 prep of,levels
R7666 T11293 T11292 pobj TNF,of
R7667 T11294 T11293 punct ",",TNF
R7668 T11295 T11293 conj IL-1β,TNF
R7669 T11296 T11295 punct ",",IL-1β
R7670 T11297 T11295 conj IL-6,IL-1β
R7671 T11298 T11297 punct ",",IL-6
R7672 T11299 T11300 amod soluble,RANKL
R7673 T11300 T11297 conj RANKL,IL-6
R7674 T11301 T11300 punct ",",RANKL
R7675 T11302 T11304 amod monocyte,protein
R7676 T11303 T11304 compound chemo-attractant,protein
R7677 T11304 T11300 appos protein,RANKL
R7678 T11305 T11304 nummod 1,protein
R7679 T11306 T11300 punct ",",RANKL
R7680 T11307 T11300 cc and,RANKL
R7681 T11308 T11300 conj IL-17,RANKL
R7682 T11309 T11283 punct ",",associated
R7683 T11310 T11283 advcl suggesting,associated
R7684 T11311 T11313 mark that,induces
R7685 T11312 T11313 nsubj A20,induces
R7686 T11313 T11310 ccomp induces,suggesting
R7687 T11314 T11316 det a,effect
R7688 T11315 T11316 amod protective,effect
R7689 T11316 T11313 dobj effect,induces
R7690 T11317 T11316 prep in,effect
R7691 T11318 T11320 amod collagen-induced,mice
R7692 T11319 T11320 compound arthritis,mice
R7693 T11320 T11317 pobj mice,in
R7694 T11321 T11313 prep through,induces
R7695 T11322 T11321 pobj suppression,through
R7696 T11323 T11322 prep of,suppression
R7697 T11324 T11325 amod NF-κB,activation
R7698 T11325 T11323 pobj activation,of
R7699 T11326 T11325 cc and,activation
R7700 T11327 T11331 punct NF,expression
R7701 T11328 T11329 punct -,κB-dependent
R7702 T11329 T11331 amod κB-dependent,expression
R7703 T11330 T11331 compound gene,expression
R7704 T11331 T11313 npadvmod expression,induces
R7705 T11332 T11331 appos [,expression
R7706 T11333 T11334 nummod 51,]
R7707 T11334 T11331 appos ],expression
R7708 T11335 T11283 punct .,associated
R7709 T11336 T11341 mark Because,known
R7710 T11337 T11341 nsubjpass TNF,known
R7711 T11338 T11337 cc and,TNF
R7712 T11339 T11337 conj IL-1β,TNF
R7713 T11340 T11341 auxpass are,known
R7714 T11341 T11370 advcl known,explain
R7715 T11342 T11343 aux to,mediate
R7716 T11343 T11341 xcomp mediate,known
R7717 T11344 T11343 dobj synovitis,mediate
R7718 T11345 T11343 punct ",",mediate
R7719 T11346 T11347 compound pannus,formation
R7720 T11347 T11343 conj formation,mediate
R7721 T11348 T11347 punct ",",formation
R7722 T11349 T11347 cc and,formation
R7723 T11350 T11347 conj erosion,formation
R7724 T11351 T11350 prep of,erosion
R7725 T11352 T11351 pobj cartilage,of
R7726 T11353 T11352 cc and,cartilage
R7727 T11354 T11352 conj bone,cartilage
R7728 T11355 T11347 prep in,formation
R7729 T11356 T11355 pobj RA,in
R7730 T11357 T11370 punct ",",explain
R7731 T11358 T11361 det the,levels
R7732 T11359 T11361 amod decreased,levels
R7733 T11360 T11361 compound serum,levels
R7734 T11361 T11370 nsubj levels,explain
R7735 T11362 T11361 prep of,levels
R7736 T11363 T11362 pobj TNF,of
R7737 T11364 T11363 cc and,TNF
R7738 T11365 T11363 conj IL-1β,TNF
R7739 T11366 T11361 prep in,levels
R7740 T11367 T11368 amod A20-transduced,mice
R7741 T11368 T11366 pobj mice,in
R7742 T11369 T11370 aux might,explain
R7743 T11370 T11370 ROOT explain,explain
R7744 T11371 T11373 det the,effects
R7745 T11372 T11373 amod beneficial,effects
R7746 T11373 T11370 dobj effects,explain
R7747 T11374 T11373 prep in,effects
R7748 T11375 T11378 det the,pathological
R7749 T11376 T11378 amod clinical,pathological
R7750 T11377 T11378 punct ",",pathological
R7751 T11378 T11374 pobj pathological,in
R7752 T11379 T11373 punct ",",effects
R7753 T11380 T11373 cc and,effects
R7754 T11381 T11382 amod radiological,findings
R7755 T11382 T11373 conj findings,effects
R7756 T11383 T11370 punct .,explain
R7757 T11384 T11385 det This,study
R7758 T11385 T11387 nsubj study,demonstrated
R7759 T11386 T11387 advmod also,demonstrated
R7760 T11387 T11387 ROOT demonstrated,demonstrated
R7761 T11388 T11391 mark that,leads
R7762 T11389 T11390 nummod A20,overexpression
R7763 T11390 T11391 nsubj overexpression,leads
R7764 T11391 T11387 ccomp leads,demonstrated
R7765 T11392 T11391 prep to,leads
R7766 T11393 T11394 det a,decrease
R7767 T11394 T11392 pobj decrease,to
R7768 T11395 T11394 prep in,decrease
R7769 T11396 T11397 det the,number
R7770 T11397 T11395 pobj number,in
R7771 T11398 T11397 prep of,number
R7772 T11399 T11400 amod activated,osteoclasts
R7773 T11400 T11398 pobj osteoclasts,of
R7774 T11401 T11400 prep in,osteoclasts
R7775 T11402 T11403 amod joint,tissue
R7776 T11403 T11401 pobj tissue,in
R7777 T11404 T11387 punct .,demonstrated
R7778 T11405 T11408 nsubj A20,minimise
R7779 T11406 T11408 aux might,minimise
R7780 T11407 T11408 advmod therefore,minimise
R7781 T11408 T11408 ROOT minimise,minimise
R7782 T11409 T11410 amod joint,destruction
R7783 T11410 T11408 dobj destruction,minimise
R7784 T11411 T11408 prep through,minimise
R7785 T11412 T11411 pcomp decreasing,through
R7786 T11413 T11415 det the,number
R7787 T11414 T11415 amod osteoclast,number
R7788 T11415 T11412 dobj number,decreasing
R7789 T11416 T11415 cc and,number
R7790 T11417 T11415 conj activity,number
R7791 T11418 T11408 punct .,minimise
R7792 T11419 T11421 nsubj It,be
R7793 T11420 T11421 aux will,be
R7794 T11421 T11421 ROOT be,be
R7795 T11422 T11421 acomp interesting,be
R7796 T11423 T11424 aux to,analyse
R7797 T11424 T11421 xcomp analyse,be
R7798 T11425 T11424 prep in,analyse
R7799 T11426 T11425 pobj future,in
R7800 T11427 T11428 det the,susceptibility
R7801 T11428 T11424 dobj susceptibility,analyse
R7802 T11429 T11428 prep of,susceptibility
R7803 T11430 T11432 amod conditional,mice
R7804 T11431 T11432 compound knockout,mice
R7805 T11432 T11429 pobj mice,of
R7806 T11433 T11434 nsubj that,lack
R7807 T11434 T11432 relcl lack,mice
R7808 T11435 T11434 dobj A20,lack
R7809 T11436 T11435 prep in,A20
R7810 T11437 T11439 amod specific,types
R7811 T11438 T11439 compound cell,types
R7812 T11439 T11436 pobj types,in
R7813 T11440 T11441 amod such,as
R7814 T11441 T11439 prep as,types
R7815 T11442 T11443 amod synovial,fibroblasts
R7816 T11443 T11441 pobj fibroblasts,as
R7817 T11444 T11443 punct ",",fibroblasts
R7818 T11445 T11443 conj macrophages,fibroblasts
R7819 T11446 T11445 punct ",",macrophages
R7820 T11447 T11448 amod dendritic,cells
R7821 T11448 T11445 conj cells,macrophages
R7822 T11449 T11445 punct ",",macrophages
R7823 T11450 T11451 compound B,cells
R7824 T11451 T11445 conj cells,macrophages
R7825 T11452 T11451 cc or,cells
R7826 T11453 T11454 compound T,cells
R7827 T11454 T11451 conj cells,cells
R7828 T11455 T11421 punct .,be
R7829 T11456 T11467 advmod Importantly,associated
R7830 T11457 T11467 punct ",",associated
R7831 T11458 T11459 amod several,SNPs
R7832 T11459 T11467 nsubjpass SNPs,associated
R7833 T11460 T11459 prep in,SNPs
R7834 T11461 T11464 det the,locus
R7835 T11462 T11464 amod human,locus
R7836 T11463 T11464 compound A20,locus
R7837 T11464 T11460 pobj locus,in
R7838 T11465 T11467 aux have,associated
R7839 T11466 T11467 auxpass been,associated
R7840 T11467 T11467 ROOT associated,associated
R7841 T11468 T11467 prep with,associated
R7842 T11469 T11470 amod increased,susceptibility
R7843 T11470 T11468 pobj susceptibility,with
R7844 T11471 T11470 prep to,susceptibility
R7845 T11472 T11471 pobj development,to
R7846 T11473 T11472 prep of,development
R7847 T11474 T11475 amod autoimmune,pathologies
R7848 T11475 T11473 pobj pathologies,of
R7849 T11476 T11477 punct (,reviewed
R7850 T11477 T11475 acl reviewed,pathologies
R7851 T11495 T11494 prep in,mutations
R7852 T11478 T11477 prep in,reviewed
R7853 T11496 T11498 det the,locus
R7854 T11479 T11478 pobj [,in
R7855 T11497 T11498 compound A20,locus
R7856 T11498 T11495 pobj locus,in
R7857 T11480 T11481 nummod 52,]
R7858 T11499 T11494 prep in,mutations
R7859 T11500 T11502 det the,chromosome
R7860 T11481 T11479 appos ],[
R7861 T11501 T11502 amod 6q23,chromosome
R7862 T11502 T11499 pobj chromosome,in
R7863 T11503 T11502 cc and,chromosome
R7864 T11482 T11479 punct ),[
R7865 T11504 T11502 conj susceptibility,chromosome
R7866 T11505 T11504 prep to,susceptibility
R7867 T11506 T11507 compound RA,[
R7868 T11483 T11467 punct .,associated
R7869 T11507 T11505 pobj [,to
R7870 T11508 T11509 nummod 52,]
R7871 T11509 T11507 appos ],[
R7872 T11510 T11489 punct .,revealed
R7873 T11484 T11487 amod Several,studies
R7874 T11511 T11517 mark Although,located
R7875 T11512 T11514 det the,variants
R7876 T11485 T11486 compound genome-wide,association
R7877 T11513 T11514 amod identified,variants
R7878 T11514 T11517 nsubjpass variants,located
R7879 T11515 T11517 auxpass are,located
R7880 T11486 T11487 compound association,studies
R7881 T11516 T11517 neg not,located
R7882 T11517 T11524 advcl located,thought
R7883 T11518 T11517 prep in,located
R7884 T11487 T11489 nsubj studies,revealed
R7885 T11519 T11520 det a,gene
R7886 T11520 T11518 pobj gene,in
R7887 T11521 T11524 punct ",",thought
R7888 T11488 T11489 advmod also,revealed
R7889 T11522 T11524 nsubjpass they,thought
R7890 T11523 T11524 auxpass are,thought
R7891 T11489 T11489 ROOT revealed,revealed
R7892 T11524 T11524 ROOT thought,thought
R7893 T11525 T11526 aux to,influence
R7894 T11526 T11524 xcomp influence,thought
R7895 T11527 T11526 dobj A20,influence
R7896 T11490 T11492 det a,association
R7897 T11528 T11526 prep as,influence
R7898 T11529 T11531 poss its,gene
R7899 T11491 T11492 amod clear,association
R7900 T11530 T11531 amod nearest,gene
R7901 T11531 T11528 pobj gene,as
R7902 T11532 T11531 punct (,gene
R7903 T11533 T11531 appos ~,gene
R7904 T11492 T11489 dobj association,revealed
R7905 T11534 T11535 nummod 150,kb
R7906 T11535 T11533 appos kb,~
R7907 T11493 T11492 prep between,association
R7908 T11536 T11535 amod downstream,kb
R7909 T11537 T11536 prep of,downstream
R7910 T11538 T11537 pobj A20,of
R7911 T11494 T11493 pobj mutations,between
R7912 T11539 T11535 punct ),kb
R7913 T11540 T11531 punct ",",gene
R7914 T11541 T11542 advmod probably,by
R7915 T11592 T11589 dobj activity,affect
R7916 T11542 T11526 prep by,influence
R7917 T11543 T11544 det the,presence
R7918 T11544 T11542 pobj presence,by
R7919 T11545 T11544 prep of,presence
R7920 T11593 T11592 cc and,activity
R7921 T11546 T11549 amod potential,elements
R7922 T11547 T11549 amod regulatory,elements
R7923 T11548 T11549 compound DNA,elements
R7924 T11594 T11596 advmod how,cause
R7925 T11549 T11545 pobj elements,of
R7926 T11550 T11549 prep in,elements
R7927 T11551 T11552 det this,region
R7928 T11595 T11596 nsubj they,cause
R7929 T11552 T11550 pobj region,in
R7930 T11553 T11524 punct .,thought
R7931 T11554 T11557 mark As,required
R7932 T11596 T11601 advcl cause,remain
R7933 T11555 T11557 nsubjpass A20,required
R7934 T11556 T11557 auxpass is,required
R7935 T11557 T11576 advcl required,reveal
R7936 T11558 T11557 prep for,required
R7937 T11597 T11596 dobj RA,cause
R7938 T11559 T11558 pobj termination,for
R7939 T11560 T11559 prep of,termination
R7940 T11561 T11562 amod TNF-induced,signals
R7941 T11598 T11601 punct ",",remain
R7942 T11562 T11560 pobj signals,of
R7943 T11563 T11557 punct ",",required
R7944 T11564 T11557 cc and,required
R7945 T11565 T11566 nsubj TNF,is
R7946 T11566 T11557 conj is,required
R7947 T11567 T11570 det the,cytokine
R7948 T11599 T11601 advmod however,remain
R7949 T11568 T11570 amod primary,cytokine
R7950 T11569 T11570 amod inflammatory,cytokine
R7951 T11570 T11566 attr cytokine,is
R7952 T11571 T11570 prep in,cytokine
R7953 T11600 T11601 punct ",",remain
R7954 T11572 T11571 pobj RA,in
R7955 T11573 T11576 punct ",",reveal
R7956 T11574 T11575 det these,findings
R7957 T11575 T11576 nsubj findings,reveal
R7958 T11601 T11601 ROOT remain,remain
R7959 T11576 T11576 ROOT reveal,reveal
R7960 T11577 T11576 dobj A20,reveal
R7961 T11602 T11601 acomp unclear,remain
R7962 T11578 T11576 prep as,reveal
R7963 T11579 T11582 det a,locus
R7964 T11580 T11581 compound candidate,susceptibility
R7965 T11603 T11601 punct .,remain
R7966 T11581 T11582 compound susceptibility,locus
R7967 T11582 T11578 pobj locus,as
R7968 T11583 T11582 prep for,locus
R7969 T11604 T11610 advmod Recently,evaluated
R7970 T11584 T11583 pobj RA,for
R7971 T11585 T11576 punct .,reveal
R7972 T11586 T11589 advmod How,affect
R7973 T11587 T11588 det these,variants
R7974 T11605 T11610 punct ",",evaluated
R7975 T11588 T11589 nsubj variants,affect
R7976 T11589 T11601 advcl affect,remain
R7977 T11590 T11592 amod normal,activity
R7978 T11606 T11610 nsubj Elsby,evaluated
R7979 T11591 T11592 amod A20,activity
R7980 T11607 T11606 cc and,Elsby
R7981 T11608 T11606 conj colleagues,Elsby
R7982 T11609 T11610 advmod functionally,evaluated
R7983 T11610 T11610 ROOT evaluated,evaluated
R7984 T11611 T11610 prep in,evaluated
R7985 T11612 T11611 pobj vitro,in
R7986 T11613 T11615 det the,ability
R7987 T11614 T11615 amod regulatory,ability
R7988 T11615 T11610 dobj ability,evaluated
R7989 T11616 T11615 prep of,ability
R7990 T11617 T11619 amod RA-associated,variants
R7991 T11618 T11619 compound SNP,variants
R7992 T11619 T11616 pobj variants,of
R7993 T11620 T11615 prep on,ability
R7994 T11621 T11623 compound A20,activity
R7995 T11622 T11623 compound promoter,activity
R7996 T11623 T11620 pobj activity,on
R7997 T11624 T11610 punct ",",evaluated
R7998 T11625 T11610 cc and,evaluated
R7999 T11626 T11627 aux could,show
R8000 T11627 T11610 conj show,evaluated
R8001 T11628 T11630 amod repressed,transcription
R8002 T11629 T11630 compound A20,transcription
R8003 T11630 T11627 dobj transcription,show
R8004 T11631 T11630 prep for,transcription
R8005 T11632 T11631 pobj some,for
R8006 T11633 T11632 prep of,some
R8007 T11634 T11635 det the,SNPs
R8008 T11635 T11633 pobj SNPs,of
R8009 T11636 T11627 conj investigated,show
R8010 T11637 T11639 nmod [,]
R8011 T11638 T11639 nummod 53,]
R8012 T11639 T11636 dobj ],investigated
R8013 T11640 T11610 punct .,evaluated
R8014 T11641 T11643 nsubj It,be
R8015 T11642 T11643 aux will,be
R8016 T11643 T11643 ROOT be,be
R8017 T11644 T11643 prep of,be
R8018 T11645 T11644 pobj interest,of
R8019 T11646 T11647 aux to,identify
R8020 T11647 T11643 advcl identify,be
R8021 T11648 T11651 det the,variants
R8022 T11649 T11651 amod actual,variants
R8023 T11650 T11651 amod causal,variants
R8024 T11651 T11647 dobj variants,identify
R8026 T11652 T11647 cc and,identify
R8027 T11653 T11654 aux to,elucidate
R8029 T11654 T11647 conj elucidate,identify
R8031 T11655 T11657 det the,consequences
R8033 T11656 T11657 amod functional,consequences
R8034 T11657 T11654 dobj consequences,elucidate
R8035 T11658 T11657 prep of,consequences
R8037 T11659 T11660 det these,variants
R8039 T11660 T11658 pobj variants,of
R8041 T11661 T11643 punct .,be
R8043 T11662 T11682 prep In,be
R8044 T11663 T11664 det this,context
R8046 T11664 T11662 pobj context,In
R8048 T11665 T11682 punct ",",be
R8052 T11666 T11667 nmod knockin,mice
R8055 T11667 T11682 nsubj mice,be
R8063 T11668 T11667 prep for,mice
R8067 T11669 T11672 det the,SNPs
R8070 T11670 T11672 amod corresponding,SNPs
R8072 T11671 T11672 compound A20,SNPs
R8075 T11672 T11668 pobj SNPs,for
R8077 T11673 T11672 punct ",",SNPs
R8080 T11674 T11672 acl combined,SNPs
R8081 T11675 T11674 prep with,combined
R8083 T11676 T11677 compound mouse,models
R8086 T11677 T11675 pobj models,with
R8087 T11678 T11677 prep for,models
R8088 T11679 T11678 pobj RA,for
R8089 T11680 T11682 punct ",",be
R8090 T11681 T11682 aux will,be
R8091 T11682 T11682 ROOT be,be
R8092 T11683 T11684 advmod very,valuable
R8094 T11684 T11685 amod valuable,tools
R8098 T11685 T11682 attr tools,be
R8099 T11686 T11682 punct .,be
R8766 T13215 T13235 nsubjpass inhibitors,identified
R8767 T13216 T13215 prep of,inhibitors
R8768 T13217 T13218 compound NF-κB,ABIN-1
R8769 T13218 T13216 pobj ABIN-1,of
R8770 T13219 T13218 punct ",",ABIN-1
R8771 T13220 T13218 conj ABIN-2,ABIN-1
R8772 T13221 T13220 cc and,ABIN-2
R8773 T13222 T13220 conj ABIN-3,ABIN-2
R8774 T13223 T13225 punct (,known
R8775 T13224 T13225 advmod also,known
R8776 T13225 T13215 acl known,inhibitors
R8777 T13226 T13225 prep as,known
R8778 T13227 T13226 pobj TNIP-1,as
R8779 T13228 T13227 punct ",",TNIP-1
R8780 T13229 T13227 appos TNIP-2,TNIP-1
R8781 T13230 T13225 punct ",",known
R8782 T13231 T13225 cc and,known
R8783 T13232 T13215 appos TNIP-3,inhibitors
R8784 T13233 T13215 punct ),inhibitors
R8785 T13234 T13235 auxpass were,identified
R8786 T13235 T13235 ROOT identified,identified
R8787 T13236 T13235 prep as,identified
R8788 T13237 T13238 advmod ubiquitously,expressed
R8789 T13238 T13239 amod expressed,A20
R8790 T13239 T13240 nsubj A20,interacting
R8791 T13240 T13236 pcomp interacting,as
R8792 T13241 T13240 dobj proteins,interacting
R8793 T13242 T13235 cc and,identified
R8794 T13243 T13244 auxpass were,shown
R8795 T13244 T13235 conj shown,identified
R8796 T13245 T13246 aux to,inhibit
R8797 T13246 T13244 xcomp inhibit,shown
R8798 T13247 T13248 amod NF-κB,activation
R8799 T13248 T13246 dobj activation,inhibit
R8800 T13249 T13248 prep by,activation
R8801 T13250 T13249 pobj TNF,by
R8802 T13251 T13250 cc and,TNF
R8803 T13252 T13255 amod several,stimuli
R8804 T13253 T13255 amod other,stimuli
R8805 T13254 T13255 amod inflammatory,stimuli
R8806 T13255 T13250 conj stimuli,TNF
R8807 T13256 T13255 prep upon,stimuli
R8808 T13257 T13256 pobj overexpression,upon
R8809 T13258 T13235 punct .,identified
R8810 T13259 T13261 mark Because,contain
R8811 T13260 T13261 nsubj ABINs,contain
R8812 T13261 T13270 advcl contain,proposed
R8813 T13262 T13265 det a,motif
R8814 T13263 T13265 amod specific,motif
R8815 T13264 T13265 amod ubiquitin-binding,motif
R8816 T13265 T13261 dobj motif,contain
R8817 T13266 T13270 punct ",",proposed
R8818 T13267 T13270 nsubjpass they,proposed
R8819 T13268 T13270 aux have,proposed
R8820 T13269 T13270 auxpass been,proposed
R8821 T13270 T13270 ROOT proposed,proposed
R8822 T13271 T13272 aux to,target
R8823 T13272 T13270 xcomp target,proposed
R8824 T13273 T13272 dobj A20,target
R8825 T13274 T13272 prep to,target
R8826 T13275 T13276 amod polyubiquitinated,substrates
R8827 T13276 T13274 pobj substrates,to
R8828 T13277 T13279 compound [,]
R8829 T13278 T13279 compound "43,44",]
R8830 T13279 T13276 appos ],substrates
R8831 T13280 T13270 punct .,proposed
R8832 T13281 T13288 amod Similar,expression
R8833 T13282 T13281 prep to,Similar
R8834 T13283 T13282 pobj A20,to
R8835 T13284 T13283 punct ",",A20
R8836 T13285 T13283 conj ABIN-1,A20
R8837 T13286 T13285 cc and,ABIN-1
R8838 T13287 T13288 compound ABIN-3,expression
R8839 T13288 T13289 nsubj expression,is
R8840 T13289 T13289 ROOT is,is
R8841 T13290 T13291 advmod NF-κB,dependent
R8842 T13291 T13289 acomp dependent,is
R8843 T13292 T13289 punct ",",is
R8844 T13293 T13289 advcl implicating,is
R8845 T13294 T13296 det a,role
R8846 T13295 T13296 amod potential,role
R8847 T13296 T13293 dobj role,implicating
R8848 T13297 T13296 prep for,role
R8849 T13298 T13300 det the,complex
R8850 T13299 T13300 compound A20/ABIN,complex
R8851 T13300 T13297 pobj complex,for
R8852 T13301 T13300 prep in,complex
R8853 T13302 T13305 det the,regulation
R8854 T13303 T13305 amod negative,regulation
R8855 T13304 T13305 compound feedback,regulation
R8856 T13305 T13301 pobj regulation,in
R8857 T13306 T13305 prep of,regulation
R8858 T13307 T13308 amod NF-κB,activation
R8859 T13308 T13306 pobj activation,of
R8860 T13309 T13310 punct (,reviewed
R8861 T13310 T13296 acl reviewed,role
R8862 T13311 T13310 prep in,reviewed
R8863 T13312 T13311 pobj [,in
R8864 T13313 T13314 nummod 54,]
R8865 T13314 T13312 appos ],[
R8866 T13315 T13312 punct ),[
R8867 T13316 T13289 punct .,is
R8868 T13317 T13324 advmod Unexpectedly,exhibit
R8869 T13318 T13324 punct ",",exhibit
R8870 T13319 T13320 preconj both,ABIN-1-deficient
R8871 T13320 T13324 amod ABIN-1-deficient,exhibit
R8872 T13321 T13320 cc and,ABIN-1-deficient
R8873 T13322 T13320 conj ABIN-2-deficient,ABIN-1-deficient
R8874 T13323 T13324 nsubj mice,exhibit
R8875 T13324 T13324 ROOT exhibit,exhibit
R8876 T13325 T13326 advmod only,slightly
R8877 T13326 T13327 advmod slightly,increased
R8878 T13327 T13331 amod increased,responses
R8879 T13328 T13327 cc or,increased
R8880 T13329 T13331 amod normal,responses
R8881 T13330 T13331 compound NF-κB,responses
R8882 T13331 T13324 dobj responses,exhibit
R8883 T13332 T13331 punct ",",responses
R8884 T13333 T13331 advmod respectively,responses
R8885 T13334 T13331 punct ",",responses
R8886 T13335 T13336 advmod possibly,reflecting
R8887 T13336 T13324 advcl reflecting,exhibit
R8888 T13337 T13340 amod redundant,activities
R8889 T13338 T13340 compound NF-κB,activities
R8890 T13339 T13340 compound inhibitory,activities
R8891 T13340 T13336 dobj activities,reflecting
R8892 T13341 T13340 prep of,activities
R8893 T13342 T13346 amod multiple,]
R8894 T13343 T13344 compound ABINs,[
R8895 T13344 T13346 compound [,]
R8896 T13345 T13346 compound "55,56",]
R8897 T13346 T13341 pobj ],of
R8898 T13347 T13324 punct .,exhibit
R8899 T13348 T13349 compound Functional,ABIN-3
R8900 T13349 T13351 nsubjpass ABIN-3,expressed
R8901 T13350 T13351 auxpass is,expressed
R8902 T13351 T13351 ROOT expressed,expressed
R8903 T13352 T13351 prep in,expressed
R8904 T13353 T13352 pobj humans,in
R8905 T13354 T13351 punct ",",expressed
R8906 T13355 T13351 cc but,expressed
R8907 T13356 T13358 nsubj mice,express
R8908 T13357 T13358 advmod only,express
R8909 T13358 T13351 conj express,expressed
R8910 T13359 T13363 det a,form
R8911 T13360 T13363 amod truncated,form
R8912 T13361 T13360 cc and,truncated
R8913 T13362 T13360 conj inactive,truncated
R8914 T13363 T13358 dobj form,express
R8915 T13364 T13363 acl lacking,form
R8916 T13365 T13368 det the,domain
R8917 T13366 T13368 amod crucial,domain
R8918 T13367 T13368 compound ubiquitin-binding,domain
R8919 T13368 T13364 dobj domain,lacking
R8920 T13369 T13371 nmod [,]
R8921 T13370 T13371 nummod 57,]
R8922 T13371 T13368 appos ],domain
R8923 T13372 T13358 punct .,express
R8924 T13373 T13380 prep As,inhibits
R8925 T13374 T13373 prep for,As
R8926 T13375 T13374 pobj A20,for
R8927 T13376 T13380 punct ",",inhibits
R8928 T13377 T13380 nsubj ABIN-1,inhibits
R8929 T13378 T13380 advmod also,inhibits
R8930 T13379 T13380 advmod strongly,inhibits
R8931 T13380 T13380 ROOT inhibits,inhibits
R8932 T13381 T13382 amod TNF-induced,apoptosis
R8933 T13382 T13383 compound apoptosis,[
R8934 T13383 T13380 dobj [,inhibits
R8935 T13384 T13385 nummod 58,]
R8936 T13385 T13390 nmod ],mice
R8937 T13386 T13385 punct ",",]
R8938 T13387 T13385 cc and,]
R8939 T13388 T13385 conj ABIN-1,]
R8940 T13389 T13390 amod deficient,mice
R8941 T13390 T13391 nsubj mice,die
R8942 T13391 T13380 conj die,inhibits
R8943 T13392 T13393 advmod embryonically,due
R8944 T13393 T13391 prep due,die
R8945 T13394 T13398 nmod to,apoptosis
R8946 T13395 T13398 amod TNF-dependent,apoptosis
R8947 T13396 T13397 amod foetal,liver
R8948 T13397 T13398 compound liver,apoptosis
R8949 T13398 T13393 xcomp apoptosis,due
R8950 T13399 T13401 nmod [,]
R8951 T13400 T13401 nummod 56,]
R8952 T13401 T13398 appos ],apoptosis
R8953 T13402 T13391 punct .,die
R8954 T13403 T13410 advcl Using,identified
R8955 T13404 T13406 nmod oligonucleotide,analysis
R8956 T13405 T13406 compound microarray,analysis
R8957 T13406 T13403 dobj analysis,Using
R8958 T13407 T13410 punct ",",identified
R8959 T13408 T13410 nsubjpass ABIN-1,identified
R8960 T13409 T13410 auxpass was,identified
R8961 T13410 T13410 ROOT identified,identified
R8962 T13411 T13410 prep among,identified
R8963 T13412 T13413 amod TNF-induced,genes
R8964 T13413 T13411 pobj genes,among
R8965 T13414 T13410 prep in,identified
R8966 T13415 T13416 amod human,synoviocytes
R8967 T13416 T13414 pobj synoviocytes,in
R8968 T13417 T13410 punct ",",identified
R8969 T13418 T13410 cc and,identified
R8970 T13419 T13420 amod high,levels
R8971 T13420 T13425 nsubjpass levels,detected
R8972 T13421 T13420 prep of,levels
R8973 T13422 T13423 compound ABIN-1,mRNA
R8974 T13423 T13421 pobj mRNA,of
R8975 T13424 T13425 auxpass were,detected
R8976 T13425 T13410 conj detected,identified
R8977 T13426 T13425 prep in,detected
R8978 T13427 T13429 compound RA,biopsies
R8979 T13428 T13429 compound tissue,biopsies
R8980 T13429 T13426 pobj biopsies,in
R8981 T13430 T13425 punct ",",detected
R8982 T13431 T13425 advcl indicating,detected
R8983 T13432 T13434 det a,role
R8984 T13433 T13434 amod potential,role
R8985 T13434 T13431 dobj role,indicating
R8986 T13435 T13434 prep for,role
R8987 T13436 T13435 pobj ABIN-1,for
R8988 T13437 T13431 punct ",",indicating
R8989 T13438 T13439 advmod together,with
R8990 T13439 T13425 prep with,detected
R8991 T13440 T13439 pobj A20,with
R8992 T13441 T13425 punct ",",detected
R8993 T13442 T13425 prep in,detected
R8994 T13443 T13446 det the,regulation
R8995 T13444 T13446 amod negative,regulation
R8996 T13445 T13446 compound feedback,regulation
R8997 T13446 T13442 pobj regulation,in
R8998 T13447 T13446 prep of,regulation
R8999 T13448 T13449 compound NF-κB,signalling
R9000 T13449 T13447 pobj signalling,of
R9001 T13450 T13449 cc and,signalling
R9002 T13451 T13452 det the,pathogenesis
R9003 T13452 T13449 conj pathogenesis,signalling
R9004 T13453 T13452 prep of,pathogenesis
R9005 T13454 T13455 compound RA,[
R9006 T13455 T13453 pobj [,of
R9007 T13456 T13457 nummod 59,]
R9008 T13457 T13452 appos ],pathogenesis
R9009 T13458 T13425 punct .,detected
R9010 T13459 T13480 prep In,shown
R9011 T13460 T13462 det a,study
R9012 T13461 T13462 amod recent,study
R9013 T13462 T13459 pobj study,In
R9014 T13463 T13480 punct ",",shown
R9015 T13464 T13480 nsubjpass inhibition,shown
R9016 T13465 T13464 prep of,inhibition
R9017 T13466 T13467 compound TLR,responses
R9018 T13467 T13465 pobj responses,of
R9019 T13468 T13467 prep by,responses
R9020 T13469 T13472 amod immunoreceptor,motif
R9021 T13470 T13472 amod tyrosine-based,motif
R9022 T13471 T13472 compound activation,motif
R9023 T13472 T13468 pobj motif,by
R9024 T13473 T13474 punct (,ITAM
R9025 T13474 T13472 appos ITAM,motif
R9026 T13475 T13474 punct ),ITAM
R9027 T13476 T13472 punct -,motif
R9028 T13477 T13478 amod coupled,receptors
R9029 T13478 T13480 nsubjpass receptors,shown
R9030 T13479 T13480 auxpass was,shown
R9031 T13480 T13480 ROOT shown,shown
R9032 T13481 T13482 aux to,depend
R9033 T13482 T13480 xcomp depend,shown
R9034 T13483 T13482 prep on,depend
R9035 T13484 T13485 det the,expression
R9036 T13485 T13483 pobj expression,on
R9037 T13486 T13485 prep of,expression
R9038 T13487 T13490 det the,proteins
R9039 T13488 T13490 amod NF-κB,proteins
R9040 T13489 T13490 compound inhibitory,proteins
R9042 T13491 T13485 appos ABIN-3,expression
R9043 T13492 T13491 cc and,ABIN-3
R9044 T13493 T13491 conj A20,ABIN-3
R9045 T13494 T13480 punct .,shown
R9046 T13495 T13505 advmod Moreover,suppressed
R9047 T13496 T13505 punct ",",suppressed
R9048 T13497 T13499 det this,effect
R9049 T13498 T13499 amod protective,effect
R9050 T13499 T13505 nsubjpass effect,suppressed
R9051 T13500 T13499 prep of,effect
R9052 T13501 T13502 det the,ITAM
R9053 T13502 T13500 pobj ITAM,of
R9054 T13503 T13505 auxpass was,suppressed
R9055 T13504 T13505 advmod strongly,suppressed
R9056 T13505 T13505 ROOT suppressed,suppressed
R9057 T13506 T13505 prep in,suppressed
R9058 T13507 T13508 amod inflammatory,arthritis
R9059 T13508 T13506 pobj arthritis,in
R9060 T13509 T13510 amod synovial,macrophages
R9061 T13510 T13511 compound macrophages,[
R9062 T13511 T13505 dobj [,suppressed
R9063 T13512 T13513 nummod 60,]
R9064 T13513 T13511 appos ],[
R9065 T13514 T13505 punct .,suppressed
R9066 T13515 T13521 advmod Interestingly,associated
R9067 T13516 T13521 punct ",",associated
R9068 T13517 T13518 amod ABIN-1,polymorphisms
R9069 T13518 T13521 nsubjpass polymorphisms,associated
R9070 T13519 T13521 aux have,associated
R9071 T13520 T13521 auxpass been,associated
R9072 T13521 T13521 ROOT associated,associated
R9073 T13522 T13521 prep with,associated
R9074 T13523 T13522 pobj psoriasis,with
R9075 T13524 T13523 cc and,psoriasis
R9076 T13525 T13526 amod systemic,lupus
R9077 T13526 T13523 conj lupus,psoriasis
R9078 T13527 T13521 conj erythematosus,associated
R9079 T13528 T13527 prep in,erythematosus
R9080 T13529 T13528 pobj humans,in
R9081 T13530 T13532 compound [,]
R9082 T13531 T13532 compound "61,62",]
R9083 T13532 T13521 nsubjpass ],associated
R9084 T13533 T13521 punct .,associated
R9085 T13534 T13536 det A,degree
R9086 T13535 T13536 amod high,degree
R9087 T13536 T13549 nsubjpass degree,expected
R9088 T13537 T13536 prep of,degree
R9089 T13538 T13537 pobj overlap,of
R9090 T13539 T13538 prep between,overlap
R9091 T13540 T13542 amod systemic,erythematosus
R9092 T13541 T13542 compound lupus,erythematosus
R9093 T13542 T13539 pobj erythematosus,between
R9094 T13543 T13542 cc and,erythematosus
R9095 T13544 T13545 compound RA,susceptibility
R9096 T13545 T13546 compound susceptibility,loci
R9097 T13546 T13542 conj loci,erythematosus
R9098 T13547 T13549 aux might,expected
R9099 T13548 T13549 auxpass be,expected
R9100 T13549 T13549 ROOT expected,expected
R9101 T13550 T13554 mark as,show
R9102 T13551 T13553 det the,diseases
R9103 T13552 T13553 nummod two,diseases
R9104 T13553 T13554 nsubj diseases,show
R9105 T13554 T13549 advcl show,expected
R9106 T13555 T13557 det some,overlap
R9107 T13556 T13557 amod clinical,overlap
R9108 T13557 T13554 dobj overlap,show
R9109 T13558 T13557 prep in,overlap
R9110 T13559 T13560 amod joint,involvement
R9111 T13560 T13558 pobj involvement,in
R9112 T13561 T13557 punct ",",overlap
R9113 T13562 T13563 compound autoantibody,production
R9114 T13563 T13557 conj production,overlap
R9115 T13564 T13563 punct ",",production
R9116 T13565 T13566 amod systemic,features
R9117 T13566 T13563 conj features,production
R9118 T13567 T13566 cc and,features
R9119 T13568 T13566 conj response,features
R9120 T13569 T13568 prep to,response
R9121 T13570 T13569 pobj treatments,to
R9122 T13571 T13572 amod such,as
R9123 T13572 T13570 prep as,treatments
R9124 T13573 T13574 compound B-cell,depletion
R9125 T13574 T13572 pobj depletion,as
R9126 T13575 T13574 punct (,depletion
R9127 T13576 T13574 appos rituximab,depletion
R9128 T13577 T13574 punct ),depletion
R9129 T13578 T13549 punct .,expected
R9130 T13579 T13582 nsubj It,be
R9131 T13580 T13582 aux will,be
R9132 T13581 T13582 advmod therefore,be
R9133 T13582 T13582 ROOT be,be
R9134 T13583 T13582 acomp interesting,be
R9135 T13584 T13585 aux to,investigate
R9136 T13585 T13582 xcomp investigate,be
R9137 T13586 T13601 mark whether,associated
R9138 T13587 T13601 nsubjpass SNPs,associated
R9139 T13588 T13591 nsubjpass that,reported
R9140 T13589 T13591 aux have,reported
R9141 T13590 T13591 auxpass been,reported
R9142 T13591 T13587 relcl reported,SNPs
R9143 T13592 T13594 aux to,associated
R9144 T13593 T13594 auxpass be,associated
R9145 T13594 T13591 xcomp associated,reported
R9146 T13595 T13594 prep with,associated
R9147 T13596 T13598 amod systemic,erythematosus
R9148 T13597 T13598 compound lupus,erythematosus
R9149 T13598 T13595 pobj erythematosus,with
R9150 T13599 T13601 auxpass are,associated
R9151 T13600 T13601 advmod also,associated
R9152 T13601 T13585 ccomp associated,investigate
R9153 T13602 T13601 prep with,associated
R9154 T13603 T13602 pobj RA,with
R9155 T13604 T13582 punct .,be
R9695 T14673 T14675 compound Cylindromatosis,Cylindromatosis
R9696 T14674 T14675 compound protein,Cylindromatosis
R9697 T14675 T14682 nsubjpass Cylindromatosis,identified
R9698 T14676 T14677 punct (,CYLD
R9699 T14677 T14675 appos CYLD,Cylindromatosis
R9700 T14678 T14677 punct ),CYLD
R9701 T14679 T14682 nsubjpass protein,identified
R9702 T14680 T14682 auxpass was,identified
R9703 T14681 T14682 advmod originally,identified
R9704 T14682 T14682 ROOT identified,identified
R9705 T14683 T14682 prep as,identified
R9706 T14684 T14686 det a,suppressor
R9707 T14685 T14686 compound tumour,suppressor
R9708 T14686 T14683 pobj suppressor,as
R9709 T14687 T14686 acl involved,suppressor
R9710 T14688 T14687 prep in,involved
R9711 T14689 T14690 amod familial,cylindromatosis
R9712 T14690 T14691 compound cylindromatosis,[
R9713 T14691 T14688 pobj [,in
R9714 T14692 T14693 nummod 63,]
R9715 T14693 T14691 appos ],[
R9716 T14694 T14682 punct .,identified
R9717 T14695 T14698 nsubjpass CYLD,involved
R9718 T14696 T14698 auxpass is,involved
R9719 T14697 T14698 advmod also,involved
R9720 T14698 T14721 ccomp involved,reviewed
R9721 T14699 T14721 punct ",",reviewed
R9722 T14700 T14721 advmod however,reviewed
R9723 T14701 T14721 punct ",",reviewed
R9724 T14702 T14721 prep in,reviewed
R9725 T14703 T14705 amod diverse,processes
R9726 T14704 T14705 amod physiological,processes
R9727 T14705 T14702 pobj processes,in
R9728 T14706 T14705 acl ranging,processes
R9729 T14707 T14706 prep from,ranging
R9730 T14708 T14707 pobj immunity,from
R9731 T14709 T14708 cc and,immunity
R9732 T14710 T14708 conj inflammation,immunity
R9733 T14711 T14721 prep to,reviewed
R9734 T14712 T14713 compound cell,cycle
R9735 T14713 T14714 compound cycle,progression
R9736 T14714 T14711 pobj progression,to
R9737 T14715 T14714 punct ",",progression
R9738 T14716 T14714 conj spermatogenesis,progression
R9739 T14717 T14716 punct ",",spermatogenesis
R9740 T14718 T14716 cc and,spermatogenesis
R9741 T14719 T14716 conj osteoclastogenesis,spermatogenesis
R9742 T14720 T14721 punct (,reviewed
R9743 T14721 T14721 ROOT reviewed,reviewed
R9744 T14722 T14721 prep in,reviewed
R9745 T14723 T14722 pobj [,in
R9746 T14724 T14725 nummod 64,]
R9747 T14725 T14723 appos ],[
R9748 T14726 T14723 punct ),[
R9749 T14727 T14721 punct .,reviewed
R9750 T14728 T14729 nsubj CYLD,is
R9751 T14729 T14729 ROOT is,is
R9752 T14730 T14732 det a,enzyme
R9753 T14731 T14732 amod deubiquitinating,enzyme
R9754 T14732 T14729 attr enzyme,is
R9755 T14733 T14735 nsubj that,regulates
R9756 T14734 T14735 advmod negatively,regulates
R9757 T14735 T14732 relcl regulates,enzyme
R9758 T14736 T14737 amod NF-κB,signalling
R9759 T14737 T14735 xcomp signalling,regulates
R9760 T14738 T14737 acl initiated,signalling
R9761 T14739 T14738 agent by,initiated
R9762 T14740 T14739 pobj TNFR,by
R9763 T14741 T14740 punct ",",TNFR
R9764 T14742 T14740 conj RANK,TNFR
R9765 T14743 T14742 cc and,RANK
R9766 T14744 T14742 conj T-cell,RANK
R9767 T14745 T14746 compound receptor,stimulation
R9768 T14746 T14740 appos stimulation,TNFR
R9769 T14747 T14748 punct (,reviewed
R9770 T14748 T14737 acl reviewed,signalling
R9771 T14749 T14748 prep in,reviewed
R9772 T14750 T14749 pobj [,in
R9773 T14751 T14752 nummod 64,]
R9774 T14752 T14750 appos ],[
R9775 T14753 T14750 punct ),[
R9776 T14754 T14755 punct (,Figure
R9777 T14755 T14748 appos Figure,reviewed
R9778 T14756 T14755 nummod 1,Figure
R9779 T14757 T14755 punct ),Figure
R9780 T14758 T14755 punct ",",Figure
R9781 T14759 T14755 prep by,Figure
R9782 T14760 T14764 amod deubiquitina-ting,proteins
R9783 T14761 T14764 amod several,proteins
R9784 T14762 T14763 npadvmod NF-κB,signalling
R9785 T14763 T14764 amod signalling,proteins
R9786 T14764 T14759 pobj proteins,by
R9787 T14765 T14764 prep including,proteins
R9788 T14766 T14765 pobj NEMO,including
R9789 T14767 T14766 punct ",",NEMO
R9790 T14768 T14766 conj TRAF2,NEMO
R9791 T14769 T14768 punct ",",TRAF2
R9792 T14770 T14768 conj TRAF6,TRAF2
R9793 T14771 T14770 punct ",",TRAF6
R9794 T14772 T14770 conj TRAF7,TRAF6
R9795 T14773 T14772 punct ",",TRAF7
R9796 T14774 T14772 conj RIP1,TRAF7
R9797 T14775 T14774 cc and,RIP1
R9798 T14776 T14774 conj TAK1,RIP1
R9799 T14777 T14755 punct .,Figure
R9800 T14778 T14783 nsubjpass Many,targeted
R9801 T14779 T14778 prep of,Many
R9802 T14780 T14779 pobj these,of
R9803 T14781 T14783 auxpass are,targeted
R9804 T14782 T14783 advmod also,targeted
R9805 T14783 T14783 ROOT targeted,targeted
R9806 T14784 T14783 agent by,targeted
R9807 T14785 T14784 pobj A20,by
R9808 T14786 T14783 cc and,targeted
R9809 T14787 T14788 nsubj it,is
R9810 T14788 T14783 conj is,targeted
R9811 T14789 T14788 advmod still,is
R9812 T14790 T14788 neg not,is
R9813 T14791 T14788 acomp clear,is
R9814 T14792 T14795 advmod why,needs
R9815 T14793 T14794 det the,cell
R9816 T14794 T14795 nsubj cell,needs
R9817 T14795 T14788 ccomp needs,is
R9818 T14796 T14802 nsubj A20,control
R9819 T14797 T14799 advmod as,as
R9820 T14798 T14799 advmod well,as
R9821 T14799 T14796 cc as,A20
R9822 T14800 T14796 conj CYLD,A20
R9823 T14801 T14802 aux to,control
R9824 T14802 T14795 ccomp control,needs
R9825 T14803 T14804 amod NF-κB,activation
R9826 T14804 T14802 dobj activation,control
R9827 T14805 T14788 punct .,is
R9828 T14806 T14810 mark As,expressed
R9829 T14807 T14810 nsubjpass A20,expressed
R9830 T14808 T14810 auxpass is,expressed
R9831 T14809 T14810 advmod only,expressed
R9832 T14810 T14821 advcl expressed,suggested
R9833 T14811 T14810 prep in,expressed
R9834 T14812 T14814 amod many,types
R9835 T14813 T14814 compound cell,types
R9836 T14814 T14811 pobj types,in
R9837 T14815 T14810 prep upon,expressed
R9838 T14816 T14815 pobj stimulation,upon
R9839 T14817 T14821 punct ",",suggested
R9840 T14818 T14821 nsubjpass it,suggested
R9841 T14819 T14821 aux has,suggested
R9842 T14820 T14821 auxpass been,suggested
R9843 T14821 T14821 ROOT suggested,suggested
R9844 T14822 T14826 mark that,regulates
R9845 T14823 T14824 det this,protein
R9846 T14824 T14826 nsubj protein,regulates
R9847 T14825 T14826 advmod mainly,regulates
R9848 T14826 T14821 ccomp regulates,suggested
R9849 T14827 T14828 amod later,phases
R9850 T14828 T14826 dobj phases,regulates
R9851 T14829 T14828 prep of,phases
R9852 T14830 T14831 amod NF-κB,signalling
R9853 T14831 T14829 pobj signalling,of
R9854 T14832 T14826 punct ",",regulates
R9855 T14833 T14836 mark whereas,regulate
R9856 T14834 T14836 nsubj CYLD,regulate
R9857 T14835 T14836 aux would,regulate
R9858 T14836 T14826 advcl regulate,regulates
R9859 T14837 T14836 dobj constitutive,regulate
R9860 T14838 T14837 cc and,constitutive
R9861 T14839 T14840 amod early,signalling
R9862 T14840 T14837 conj signalling,constitutive
R9863 T14841 T14821 punct .,suggested
R9864 T14842 T14850 prep In,be
R9865 T14843 T14842 pobj addition,In
R9866 T14844 T14850 punct ",",be
R9867 T14845 T14847 poss their,activity
R9868 T14846 T14847 amod relative,activity
R9869 T14847 T14850 nsubj activity,be
R9870 T14848 T14850 aux might,be
R9871 T14849 T14850 advmod also,be
R9872 T14850 T14850 ROOT be,be
R9873 T14851 T14852 npadvmod cell-type,dependent
R9874 T14852 T14855 amod dependent,]
R9875 T14853 T14855 nmod [,]
R9876 T14854 T14855 nummod 64,]
R9877 T14855 T14850 attr ],be
R9878 T14856 T14850 punct .,be
R9879 T14857 T14862 advmod Interestingly,shown
R9880 T14858 T14862 punct ",",shown
R9881 T14859 T14862 nsubjpass CYLD,shown
R9882 T14860 T14862 aux has,shown
R9883 T14861 T14862 auxpass been,shown
R9884 T14862 T14862 ROOT shown,shown
R9885 T14863 T14865 aux to,regulate
R9886 T14864 T14865 advmod negatively,regulate
R9887 T14865 T14862 xcomp regulate,shown
R9888 T14866 T14867 compound RANK,signalling
R9889 T14867 T14865 dobj signalling,regulate
R9890 T14868 T14867 cc and,signalling
R9891 T14869 T14867 conj osteoclastogenesis,signalling
R9892 T14870 T14867 prep in,signalling
R9893 T14871 T14870 pobj mice,in
R9894 T14872 T14874 nmod [,]
R9895 T14873 T14874 nummod 65,]
R9896 T14874 T14867 appos ],signalling
R9897 T14875 T14862 punct .,shown
R9898 T14876 T14883 nsubj Mice,have
R9899 T14877 T14876 prep with,Mice
R9900 T14878 T14880 det a,deficiency
R9901 T14879 T14880 amod genetic,deficiency
R9902 T14880 T14877 pobj deficiency,with
R9903 T14881 T14880 prep of,deficiency
R9904 T14882 T14881 pobj CYLD,of
R9905 T14883 T14883 ROOT have,have
R9906 T14884 T14886 amod aberrant,differentiation
R9907 T14885 T14886 compound osteoclast,differentiation
R9908 T14886 T14883 dobj differentiation,have
R9909 T14887 T14883 cc and,have
R9910 T14888 T14883 conj develop,have
R9911 T14889 T14890 amod severe,osteoporosis
R9912 T14890 T14888 dobj osteoporosis,develop
R9913 T14891 T14883 punct .,have
R9914 T14892 T14897 dep Osteoclast,are
R9915 T14893 T14897 nsubj precursors,are
R9916 T14894 T14893 prep of,precursors
R9917 T14895 T14896 det these,mice
R9918 T14896 T14894 pobj mice,of
R9919 T14897 T14897 ROOT are,are
R9920 T14898 T14897 acomp hyper-responsive,are
R9921 T14899 T14898 prep to,hyper-responsive
R9922 T14900 T14901 amod RANKL-induced,differentiation
R9923 T14901 T14899 pobj differentiation,to
R9924 T14902 T14897 cc and,are
R9925 T14903 T14897 conj produce,are
R9926 T14904 T14907 amod more,osteoclasts
R9927 T14905 T14904 cc and,more
R9928 T14906 T14904 conj larger,more
R9929 T14907 T14903 dobj osteoclasts,produce
R9930 T14908 T14897 punct .,are
R9931 T14909 T14910 compound CYLD,expression
R9932 T14910 T14913 nsubjpass expression,upregulated
R9933 T14911 T14913 auxpass is,upregulated
R9934 T14912 T14913 advmod markedly,upregulated
R9935 T14913 T14913 ROOT upregulated,upregulated
R9936 T14914 T14913 prep under,upregulated
R9937 T14915 T14914 pobj conditions,under
R9938 T14916 T14915 prep of,conditions
R9939 T14917 T14918 compound RANKL-induced,osteoclastogenesis
R9940 T14918 T14916 pobj osteoclastogenesis,of
R9941 T14919 T14913 cc and,upregulated
R9942 T14920 T14921 auxpass is,recruited
R9943 T14921 T14913 conj recruited,upregulated
R9944 T14922 T14921 prep to,recruited
R9945 T14923 T14924 amod ubiquitinated,TRAF6
R9946 T14924 T14922 pobj TRAF6,to
R9947 T14925 T14921 prep via,recruited
R9948 T14926 T14929 det the,protein
R9949 T14927 T14929 amod ubiquitin-binding,protein
R9955 T14933 T14930 acl known,p62
R9956 T14934 T14933 prep as,known
R9957 T14935 T14934 pobj sequestosome,as
R9958 T14936 T14935 nummod 1,sequestosome
R9959 T14937 T14930 punct ),p62
R9960 T14938 T14940 nmod [,]
R9961 T14939 T14940 nummod 65,]
R9962 T14940 T14940 ROOT ],]
R9963 T14941 T14940 punct ",",]
R9964 T14942 T14940 acl followed,]
R9965 T14943 T14942 agent by,followed
R9966 T14944 T14946 det the,deubiquitination
R9967 T14945 T14946 amod CYLD-mediated,deubiquitination
R9968 T14946 T14943 pobj deubiquitination,by
R9969 T14947 T14946 prep of,deubiquitination
R9970 T14948 T14947 pobj TRAF6,of
R9971 T14949 T14913 punct .,upregulated
R9972 T14950 T14955 prep In,is
R9973 T14951 T14952 det this,context
R9974 T14952 T14950 pobj context,In
R9975 T14953 T14955 punct ",",is
R9976 T14954 T14955 nsubj it,is
R9977 T14955 T14955 ROOT is,is
R9978 T14956 T14955 acomp worth,is
R9979 T14957 T14956 xcomp mentioning,worth
R9980 T14958 T14968 mark that,display
R9981 T14959 T14960 amod transgenic,mice
R9982 T14960 T14968 nsubj mice,display
R9983 T14961 T14960 acl expressing,mice
R9984 T14962 T14964 det a,form
R9985 T14963 T14964 amod mutated,form
R9986 T14964 T14961 dobj form,expressing
R9987 T14965 T14964 prep of,form
R9988 T14966 T14965 pobj p62,of
R9989 T14967 T14968 advmod also,display
R9990 T14968 T14955 ccomp display,is
R9991 T14969 T14970 amod abnormal,osteoclastogenesis
R9992 T14970 T14968 dobj osteoclastogenesis,display
R9993 T14971 T14968 cc and,display
R9994 T14972 T14968 conj develop,display
R9995 T14973 T14975 amod progressive,loss
R9996 T14974 T14975 compound bone,loss
R9997 T14975 T14972 dobj loss,develop
R9998 T14976 T14978 nmod [,]
R9999 T14977 T14978 nummod 66,]
R10000 T14978 T14975 appos ],loss
R10001 T14979 T14955 punct .,is
R10002 T14980 T14981 det These,findings
R10003 T14981 T14982 nsubj findings,suggest
R10004 T14982 T14982 ROOT suggest,suggest
R10005 T14983 T15001 mark that,indicate
R10006 T14984 T14985 amod CYLD-mediated,inhibi-tion
R10007 T14985 T15001 nsubj inhibi-tion,indicate
R10008 T14986 T14985 prep of,inhibi-tion
R10009 T14987 T14988 amod RANK-induced,NF-κB
R10010 T14988 T14989 nsubj NF-κB,signalling
R10011 T14989 T14986 pcomp signalling,of
R10012 T14990 T14989 dobj plays,signalling
R10013 T14991 T14993 det a,role
R10014 T14992 T14993 amod key,role
R10015 T14993 T14989 oprd role,signalling
R10016 T14994 T14993 prep in,role
R10017 T14995 T14997 det the,regulation
R10018 T14996 T14997 amod negative,regulation
R10019 T14997 T14994 pobj regulation,in
R10020 T14998 T14997 prep of,regulation
R10021 T14999 T14998 pobj osteoclastogenesis,of
R10022 T15000 T14989 cc and,signalling
R10023 T15001 T14982 ccomp indicate,suggest
R10029 T15007 T15003 pobj factor,as
R10030 T15008 T15007 acl involved,factor
R10031 T15009 T15008 prep in,involved
R10032 T15010 T15011 det the,pathology
R10033 T15011 T15009 pobj pathology,in
R10034 T15012 T15011 prep of,pathology
R10035 T15013 T15014 compound bone,disorders
R10036 T15014 T15012 pobj disorders,of
R10037 T15015 T15016 amod such,as
R10038 T15016 T15014 prep as,disorders
R10039 T15017 T15016 pobj RA,as
R10040 T15018 T14982 punct .,suggest
R10438 T15830 T15847 nsubj Single-immunoglobulin,is
R10439 T15831 T15833 amod IL-1,protein
R10440 T15832 T15833 amod receptor-related,protein
R10441 T15833 T15847 nsubj protein,is
R10442 T15834 T15840 nmod Single-immunoglobulin,protein
R10443 T15835 T15836 compound IL-1,receptor-related
R10444 T15836 T15840 compound receptor-related,protein
R10445 T15837 T15838 punct (,SIGIRR
R10446 T15838 T15836 appos SIGIRR,receptor-related
R10447 T15839 T15838 punct ),SIGIRR
R10448 T15840 T15833 appos protein,protein
R10449 T15841 T15840 punct ",",protein
R10450 T15842 T15843 advmod also,known
R10451 T15843 T15833 acl known,protein
R10452 T15844 T15843 prep as,known
R10453 T15845 T15844 pobj TIR-8,as
R10454 T15846 T15833 punct ",",protein
R10455 T15847 T15847 ROOT is,is
R10456 T15848 T15849 det a,member
R10457 T15849 T15847 attr member,is
R10458 T15850 T15849 prep of,member
R10459 T15851 T15855 det the,family
R10460 T15852 T15855 compound TLR/IL,family
R10461 T15853 T15854 nummod -1,R
R10462 T15854 T15855 compound R,family
R10463 T15855 T15850 pobj family,of
R10464 T15856 T15860 nsubjpass that,characterised
R10465 T15857 T15860 aux has,characterised
R10466 T15858 T15860 auxpass been,characterised
R10467 T15859 T15860 advmod extensively,characterised
R10468 T15860 T15855 relcl characterised,family
R10469 T15861 T15860 prep as,characterised
R10470 T15862 T15863 det an,inhibitor
R10471 T15863 T15861 pobj inhibitor,as
R10472 T15864 T15863 prep of,inhibitor
R10473 T15865 T15864 pobj IL-1R,of
R10474 T15866 T15865 cc and,IL-1R
R10475 T15867 T15868 compound TLR,signalling
R10476 T15868 T15865 conj signalling,IL-1R
R10477 T15869 T15847 punct ",",is
R10478 T15870 T15871 advmod probably,through
R10479 T15871 T15847 prep through,is
R10480 T15872 T15873 amod direct,interaction
R10481 T15873 T15871 pobj interaction,through
R10482 T15874 T15873 prep with,interaction
R10483 T15875 T15876 det these,receptors
R10484 T15876 T15874 pobj receptors,with
R10485 T15877 T15873 punct ",",interaction
R10486 T15878 T15873 conj MyD88,interaction
R10487 T15879 T15878 punct ",",MyD88
R10488 T15880 T15878 conj IRAK1,MyD88
R10489 T15881 T15880 cc or,IRAK1
R10490 T15882 T15883 compound TRAF6,[
R10491 T15883 T15880 conj [,IRAK1
R10492 T15884 T15885 nummod 67,]
R10493 T15885 T15880 conj ],IRAK1
R10494 T15886 T15887 punct (,Figure
R10495 T15887 T15885 appos Figure,]
R10496 T15888 T15887 nummod 1,Figure
R10497 T15889 T15887 punct ),Figure
R10498 T15890 T15847 punct .,is
R10499 T15891 T15904 prep Given,observed
R10500 T15892 T15894 det the,role
R10501 T15893 T15894 amod important,role
R10502 T15894 T15891 pobj role,Given
R10503 T15895 T15894 prep of,role
R10504 T15896 T15895 pobj IL-1R,of
R10505 T15897 T15896 cc and,IL-1R
R10506 T15898 T15896 conj TLR,IL-1R
R10507 T15899 T15894 acl signalling,role
R10508 T15900 T15899 prep in,signalling
R10509 T15901 T15903 det the,inflammation
R10510 T15902 T15903 amod chronic,inflammation
R10511 T15903 T15900 pobj inflammation,in
R10512 T15904 T15904 ROOT observed,observed
R10513 T15905 T15904 prep in,observed
R10514 T15906 T15907 compound RA,[
R10515 T15907 T15905 pobj [,in
R10516 T15908 T15909 nummod 68,]
R10517 T15909 T15918 nsubj ],is
R10518 T15910 T15909 punct ",",]
R10519 T15911 T15913 det a,role
R10520 T15912 T15913 amod regulatory,role
R10521 T15913 T15909 appos role,]
R10522 T15914 T15913 prep for,role
R10523 T15915 T15914 pobj SIGIRR,for
R10524 T15916 T15913 prep in,role
R10525 T15917 T15916 pobj RA,in
R10526 T15918 T15904 ccomp is,observed
R10527 T15919 T15918 neg not,is
R10528 T15920 T15918 acomp unlikely,is
R10529 T15921 T15904 punct .,observed
R10530 T15922 T15923 nsubj SIGIRR,has
R10531 T15923 T15923 ROOT has,has
R10532 T15924 T15928 det a,pattern
R10533 T15925 T15926 advmod very,restricted
R10534 T15926 T15928 amod restricted,pattern
R10535 T15927 T15928 compound expression,pattern
R10536 T15928 T15923 dobj pattern,has
R10537 T15929 T15928 punct ",",pattern
R10538 T15930 T15931 auxpass being,expressed
R10539 T15931 T15928 acl expressed,pattern
R10540 T15932 T15931 prep in,expressed
R10541 T15933 T15934 amod epithelial,cells
R10542 T15934 T15932 pobj cells,in
R10543 T15935 T15934 punct ",",cells
R10544 T15936 T15934 conj monocytes,cells
R10545 T15937 T15936 cc and,monocytes
R10546 T15938 T15940 amod immature,cells
R10547 T15939 T15940 amod dendritic,cells
R10548 T15940 T15936 conj cells,monocytes
R10549 T15941 T15931 punct ",",expressed
R10550 T15942 T15931 cc but,expressed
R10551 T15943 T15944 neg not,in
R10552 T15944 T15923 prep in,has
R10553 T15945 T15946 amod mature,macro-phages
R10554 T15946 T15944 pobj macro-phages,in
R10555 T15947 T15949 compound [,]
R10556 T15948 T15949 compound "69,70",]
R10557 T15949 T15944 conj ],in
R10558 T15950 T15923 punct .,has
R10559 T15951 T15956 advmod Recently,shown
R10560 T15952 T15956 punct ",",shown
R10561 T15953 T15954 compound SIGIRR,overexpression
R10562 T15954 T15956 nsubjpass overexpression,shown
R10563 T15955 T15956 auxpass was,shown
R10564 T15956 T15956 ROOT shown,shown
R10565 T15957 T15958 aux to,inhibit
R10566 T15958 T15956 xcomp inhibit,shown
R10567 T15959 T15961 det the,release
R10568 T15960 T15961 amod spontaneous,release
R10569 T15961 T15958 dobj release,inhibit
R10570 T15962 T15961 prep of,release
R10571 T15963 T15964 amod inflammatory,cytokines
R10572 T15964 T15962 pobj cytokines,of
R10573 T15965 T15961 prep by,release
R10574 T15966 T15969 amod human,cells
R10575 T15967 T15969 nmod RA,cells
R10576 T15968 T15969 amod synovial,cells
R10577 T15969 T15965 pobj cells,by
R10578 T15970 T15956 punct .,shown
R10579 T15971 T15973 det This,function
R10580 T15972 T15973 amod inhibitory,function
R10581 T15973 T15978 nsubjpass function,confirmed
R10582 T15974 T15973 prep of,function
R10583 T15975 T15974 pobj SIGIRR,of
R10584 T15976 T15978 auxpass was,confirmed
R10585 T15977 T15978 advmod further,confirmed
R10586 T15978 T15978 ROOT confirmed,confirmed
R10587 T15979 T15978 prep in,confirmed
R10588 T15980 T15979 pobj vivo,in
R10589 T15981 T15978 punct ",",confirmed
R10590 T15982 T15985 mark since,developed
R10591 T15983 T15984 amod SIGIRR-deficient,mice
R10592 T15984 T15985 nsubj mice,developed
R10593 T15985 T15978 advcl developed,confirmed
R10594 T15986 T15989 det a,disease
R10595 T15987 T15988 advmod more,severe
R10596 T15988 T15989 amod severe,disease
R10597 T15989 T15985 dobj disease,developed
R10598 T15990 T15989 prep in,disease
R10599 T15991 T15992 amod zymosan-induced,arthritis
R10600 T15992 T15990 pobj arthritis,in
R10601 T15993 T15989 punct ",",disease
R10602 T15994 T15996 advmod as,as
R10603 T15995 T15996 advmod well,as
R10604 T15996 T15989 cc as,disease
R10605 T15997 T16000 amod collagen-induced,models
R10606 T15998 T15999 compound arthritis,mouse
R10607 T15999 T16000 compound mouse,models
R10608 T16000 T15989 conj models,disease
R10609 T16001 T16001 ROOT [,[
R10610 T16002 T16003 nummod 70,]
R10611 T16003 T16003 ROOT ],]
R10612 T16004 T15978 punct .,confirmed
R10613 T16005 T16007 nsubj It,be
R10614 T16006 T16007 aux will,be
R10615 T16007 T16007 ROOT be,be
R10616 T16008 T16007 acomp interesting,be
R10617 T16009 T16010 aux to,compare
R10618 T16010 T16007 xcomp compare,be
R10619 T16011 T16012 det the,expression
R10620 T16012 T16010 dobj expression,compare
R10621 T16013 T16012 prep of,expression
R10622 T16014 T16013 pobj SIGIRR,of
R10623 T16015 T16010 prep in,compare
R10624 T16016 T16017 compound RA,patients
R10625 T16017 T16015 pobj patients,in
R10626 T16018 T16010 prep with,compare
R10627 T16019 T16020 poss its,expression
R10628 T16020 T16018 pobj expression,with
R10629 T16021 T16020 prep in,expression
R10630 T16022 T16023 compound control,patients
R10631 T16023 T16021 pobj patients,in
R10632 T16024 T16020 punct ",",expression
R10633 T16025 T16010 cc or,compare
R10634 T16026 T16027 aux to,investigate
R10635 T16027 T16010 conj investigate,compare
R10636 T16028 T16034 mark whether,compromised
R10637 T16029 T16030 det the,function
R10638 T16030 T16034 nsubjpass function,compromised
R10639 T16031 T16030 prep of,function
R10640 T16032 T16031 pobj SIGIRR,of
R10641 T16033 T16034 auxpass is,compromised
R10642 T16034 T16027 ccomp compromised,investigate
R10643 T16035 T16034 prep in,compromised
R10644 T16036 T16037 compound RA,patients
R10645 T16037 T16035 pobj patients,in
R10646 T16038 T16007 punct .,be
R10647 T16039 T16049 prep Because,be
R10648 T16040 T16039 pcomp of,Because
R10649 T16041 T16044 poss its,pattern
R11024 T16746 T16748 nmod TNF,factor
R11025 T16747 T16748 amod receptor-associated,factor
R11026 T16748 T16751 nsubj factor,is
R11027 T16749 T16748 nummod 1,factor
R11028 T16750 T16748 nummod TRAF1,factor
R11029 T16751 T16751 ROOT is,is
R11030 T16752 T16754 det a,member
R11031 T16753 T16754 amod unique,member
R11032 T16754 T16751 attr member,is
R11033 T16755 T16754 prep of,member
R11034 T16756 T16759 det the,family
R11035 T16757 T16759 compound TRAF,family
R11036 T16758 T16759 compound protein,family
R11037 T16759 T16755 pobj family,of
R11038 T16760 T16762 mark because,lacks
R11039 T16761 T16762 nsubj it,lacks
R11040 T16762 T16751 advcl lacks,is
R11041 T16763 T16766 det a,domain
R11042 T16764 T16766 compound RING,domain
R11043 T16765 T16766 compound finger,domain
R11044 T16766 T16762 dobj domain,lacks
R11045 T16767 T16762 cc and,lacks
R11046 T16768 T16769 advmod therefore,lacks
R11047 T16769 T16762 conj lacks,lacks
R11048 T16770 T16772 amod ubiquitin,activity
R11049 T16771 T16772 compound ligase,activity
R11050 T16772 T16769 dobj activity,lacks
R11051 T16773 T16751 punct .,is
R11052 T16774 T16774 ROOT Accumulating,Accumulating
R11053 T16775 T16776 nsubj data,support
R11054 T16776 T16774 dobj support,Accumulating
R11055 T16777 T16778 det a,role
R11056 T16778 T16776 dobj role,support
R11057 T16779 T16778 prep for,role
R11058 T16780 T16779 pobj TRAF1,for
R11059 T16781 T16776 prep as,support
R11060 T16782 T16784 det both,negative
R11061 T16783 T16784 det a,negative
R11062 T16784 T16781 pobj negative,as
R11063 T16785 T16784 cc and,negative
R11064 T16786 T16788 det a,modulator
R11065 T16787 T16788 amod positive,modulator
R11066 T16788 T16784 conj modulator,negative
R11092 T16814 T16813 cc and,TNF
R11093 T16815 T16813 conj overexpression,TNF
R11094 T16816 T16815 prep of,overexpression
R11095 T16817 T16818 nummod TRAF1,inhibits
R11096 T16818 T16816 pobj inhibits,of
R11097 T16819 T16821 nmod TNF-induced,activation
R11098 T16820 T16821 compound NF-κB,activation
R11099 T16821 T16815 conj activation,overexpression
R11100 T16822 T16810 punct .,is
R11101 T16823 T16825 amod TRAF1-deficient,cells
R11102 T16824 T16825 compound T,cells
R11103 T16825 T16826 nsubj cells,are
R11104 T16826 T16826 ROOT are,are
R11105 T16827 T16826 acomp hyper-responsive,are
R11106 T16828 T16827 prep to,hyper-responsive
R11107 T16829 T16828 pobj TNF,to
R11108 T16830 T16826 punct ",",are
R11109 T16831 T16826 prep with,are
R11110 T16832 T16833 amod enhanced,proliferation
R11111 T16833 T16831 pobj proliferation,with
R11112 T16834 T16833 cc and,proliferation
R11113 T16835 T16833 conj activation,proliferation
R11114 T16836 T16833 prep of,proliferation
R11115 T16837 T16840 det the,pathway
R11116 T16838 T16840 amod NF-κB,pathway
R11117 T16839 T16840 amod signalling,pathway
R11118 T16840 T16836 pobj pathway,of
R11119 T16841 T16826 punct .,are
R11120 T16842 T16844 nummod TRAF1,functions
R11122 T16844 T16844 ROOT functions,functions
R11123 T16845 T16844 prep as,functions
R11124 T16846 T16848 det a,regulator
R11125 T16847 T16848 amod negative,regulator
R11126 T16848 T16845 pobj regulator,as
R11127 T16849 T16848 prep of,regulator
R11128 T16850 T16852 amod CD40-induced,activation
R11129 T16851 T16852 compound NF-κB,activation
R11130 T16852 T16849 pobj activation,of
R11131 T16853 T16844 punct .,functions
R11132 T16854 T16856 amod TRAF1-deficient,cells
R11133 T16855 T16856 amod dendritic,cells
R11134 T16856 T16860 nsubj cells,show
R11135 T16857 T16860 punct ",",show
R11136 T16858 T16860 advmod however,show
R11137 T16859 T16860 punct ",",show
R11138 T16860 T16860 ROOT show,show
R11139 T16861 T16862 amod attenuated,responses
R11140 T16862 T16860 dobj responses,show
R11141 T16863 T16862 prep to,responses
R11142 T16864 T16865 amod secondary,stimulation
R11143 T16865 T16863 pobj stimulation,to
R11144 T16866 T16862 prep by,responses
R11145 T16867 T16868 amod TRAF2-dependent,factors
R11146 T16868 T16866 pobj factors,by
R11147 T16869 T16862 punct ",",responses
R11148 T16870 T16860 advcl suggesting,show
R11149 T16871 T16874 det a,role
R11150 T16872 T16874 amod positive,role
R11151 T16873 T16874 amod regulatory,role
R11152 T16874 T16870 dobj role,suggesting
R11153 T16875 T16874 prep in,role
R11154 T16876 T16877 det these,cells
R11155 T16877 T16875 pobj cells,in
R11156 T16878 T16860 punct .,show
R11157 T16879 T16880 det The,mechanism
R11158 T16880 T16889 nsubj mechanism,is
R11159 T16881 T16884 prep by,modulates
R11160 T16882 T16881 pobj which,by
R11161 T16883 T16884 nsubj TRAF1,modulates
R11162 T16884 T16880 relcl modulates,mechanism
R11163 T16885 T16884 punct NF,modulates
R11164 T16886 T16880 punct -,mechanism
R11165 T16887 T16888 compound κB,activation
R11166 T16888 T16880 appos activation,mechanism
R11167 T16889 T16889 ROOT is,is
R11168 T16890 T16889 advmod still,is
R11169 T16891 T16889 acomp unclear,is
R11170 T16892 T16889 punct .,is
R11171 T16893 T16894 advmod Most,probably
R11172 T16894 T16897 advmod probably,competes
R11173 T16895 T16897 punct ",",competes
R11174 T16896 T16897 nsubj TRAF1,competes
R11175 T16897 T16897 ROOT competes,competes
R11176 T16898 T16897 prep with,competes
R11177 T16899 T16901 compound TRAF,members
R11178 T16900 T16901 compound family,members
R11179 T16901 T16898 pobj members,with
R11180 T16902 T16897 prep for,competes
R11181 T16903 T16902 amod binding,for
R11182 T16904 T16903 prep to,binding
R11183 T16905 T16906 det the,receptor
R11184 T16906 T16904 pobj receptor,to
R11185 T16907 T16906 cc or,receptor
R11186 T16908 T16910 amod other,proteins
R11187 T16909 T16910 amod signalling,proteins
R11188 T16910 T16906 conj proteins,receptor
R11189 T16911 T16897 punct .,competes
R11190 T16912 T16916 advmod Alternatively,recruit
R11191 T16913 T16916 punct ",",recruit
R11192 T16914 T16916 nsubj TRAF1,recruit
R11193 T16915 T16916 aux might,recruit
R11194 T16916 T16916 ROOT recruit,recruit
R11195 T16917 T16916 dobj A20,recruit
R11196 T16918 T16923 prep with,interact
R11197 T16919 T16918 pobj which,with
R11198 T16920 T16923 nsubj it,interact
R11199 T16921 T16923 aux can,interact
R11200 T16922 T16923 advmod physically,interact
R11201 T16923 T16916 conj interact,recruit
R11202 T16924 T16923 dobj [,interact
R11203 T16925 T16926 nummod 73,]
R11204 T16926 T16924 appos ],[
R11205 T16927 T16916 punct .,recruit
R11206 T16928 T16931 det A,study
R11207 T16929 T16930 compound genome-wide,association
R11208 T16930 T16931 compound association,study
R11209 T16931 T16946 nsubj study,identified
R11210 T16932 T16931 acl examining,study
R11211 T16933 T16935 amod more,"300,000"
R11212 T16934 T16935 quantmod than,"300,000"
R11213 T16935 T16936 nummod "300,000",SNPs
R11214 T16936 T16932 dobj SNPs,examining
R11215 T16937 T16932 prep among,examining
R11216 T16938 T16939 advmod approximately,"1,500"
R11217 T16939 T16942 nummod "1,500",cases
R11218 T16940 T16942 amod autoantibody-positive,cases
R11219 T16941 T16942 compound RA,cases
R11220 T16942 T16937 pobj cases,among
R11221 T16943 T16942 cc and,cases
R11222 T16944 T16945 nummod "1,800",controls
R11223 T16945 T16942 conj controls,cases
R11224 T16946 T16946 ROOT identified,identified
R11225 T16947 T16949 det a,variation
R11226 T16948 T16949 amod genetic,variation
R11227 T16949 T16946 dobj variation,identified
R11228 T16950 T16946 prep at,identified
R11229 T16951 T16953 det the,component
R11230 T16952 T16953 compound TRAF1-complement,component
R11231 T16953 T16950 pobj component,at
R11232 T16954 T16955 nummod 5,locus
R11233 T16955 T16946 npadvmod locus,identified
R11234 T16956 T16961 mark as,locus
R11235 T16957 T16960 det an,risk
R11236 T16958 T16960 amod important,risk
R11237 T16959 T16960 compound RA,risk
R11238 T16960 T16961 nsubj risk,locus
R11239 T16961 T16946 advcl locus,identified
R11240 T16962 T16964 nmod [,]
R11241 T16963 T16964 nummod 74,]
R11242 T16964 T16961 dobj ],locus
R11243 T16965 T16946 punct .,identified
R11244 T16966 T16967 amod Subsequent,work
R11245 T16967 T16968 nsubj work,indicates
R11246 T16968 T16968 ROOT indicates,indicates
R11247 T16969 T16971 mark that,is
R11248 T16970 T16971 nsubj TRAF1,is
R11249 T16971 T16968 ccomp is,indicates
R11250 T16972 T16973 advmod more,likely
R11251 T16973 T16971 acomp likely,is
R11252 T16974 T16975 aux to,be
R11253 T16975 T16973 xcomp be,likely
R11254 T16976 T16978 det the,locus
R11255 T16977 T16978 amod causative,locus
R11256 T16978 T16975 attr locus,be
R11257 T16979 T16981 nmod [,]
R11258 T16980 T16981 nummod 75,]
R11259 T16981 T16978 appos ],locus
R11260 T16982 T16968 punct .,indicates
R11261 T16983 T16984 amod Recent,work
R11262 T16984 T16990 nsubj work,demonstrates
R11263 T16985 T16984 prep in,work
R11264 T16986 T16988 det a,population
R11265 T16987 T16988 amod Korean,population
R11266 T16988 T16985 pobj population,in
R11267 T16989 T16990 advmod also,demonstrates
R11268 T16990 T16990 ROOT demonstrates,demonstrates
R11269 T16991 T16992 amod genetic,association
R11270 T16992 T16990 dobj association,demonstrates
R11271 T16993 T16992 prep of,association
R11272 T16994 T16996 det the,region
R11273 T16995 T16996 nummod TRAF1,region
R11274 T16996 T16993 pobj region,of
R11275 T16997 T16990 prep with,demonstrates
R11276 T16998 T16999 compound RA,[
R11279 T17001 T16999 appos ],[
R11280 T17002 T16990 punct .,demonstrates
R11895 T18039 T18040 compound microRNAs,miRNAs
R11896 T18040 T18043 nsubjpass miRNAs,discovered
R11897 T18041 T18043 auxpass are,discovered
R11898 T18042 T18043 advmod recently,discovered
R11899 T18043 T18043 ROOT discovered,discovered
R11900 T18044 T18043 dobj regulators,discovered
R11901 T18045 T18044 prep of,regulators
R11902 T18046 T18047 compound gene,expression
R11903 T18047 T18045 pobj expression,of
R11904 T18048 T18043 cc and,discovered
R11905 T18049 T18043 conj represent,discovered
R11906 T18050 T18051 det a,class
R11907 T18051 T18049 dobj class,represent
R11908 T18052 T18051 prep of,class
R11909 T18053 T18052 pcomp noncoding,of
R11910 T18054 T18055 compound RNA,molecules
R11911 T18055 T18053 dobj molecules,noncoding
R11912 T18056 T18051 amod essential,class
R11913 T18057 T18051 prep in,class
R11914 T18058 T18062 amod many,processes
R11915 T18059 T18062 amod cellular,processes
R11916 T18060 T18059 cc and,cellular
R11917 T18061 T18059 conj developmental,cellular
R11918 T18062 T18057 pobj processes,in
R11919 T18063 T18062 punct ",",processes
R11920 T18064 T18062 prep including,processes
R11921 T18065 T18066 amod immune,responses
R11922 T18066 T18064 pobj responses,including
R11923 T18067 T18066 cc and,responses
R11924 T18068 T18066 conj inflammation,responses
R11925 T18069 T18043 punct .,discovered
R11926 T18070 T18071 nsubj They,bind
R11927 T18071 T18071 ROOT bind,bind
R11928 T18072 T18073 det the,3
R11929 T18073 T18076 meta 3,UTR
R11930 T18074 T18073 punct ',3
R11931 T18075 T18076 punct -,UTR
R11932 T18076 T18071 dobj UTR,bind
R11933 T18077 T18076 prep of,UTR
R11934 T18078 T18079 compound target,mRNAs
R11935 T18079 T18077 pobj mRNAs,of
R11936 T18080 T18079 acl leading,mRNAs
R11937 T18081 T18080 prep to,leading
R11938 T18082 T18083 det the,repression
R11939 T18083 T18081 pobj repression,to
R11940 T18084 T18083 prep of,repression
R11941 T18085 T18086 compound protein,expression
R11942 T18086 T18084 pobj expression,of
R11943 T18087 T18086 cc and,expression
R11944 T18088 T18089 det the,promotion
R11945 T18089 T18086 conj promotion,expression
R11946 T18090 T18089 prep of,promotion
R11947 T18091 T18092 compound target,mRNA
R11948 T18092 T18093 compound mRNA,degradation
R11949 T18093 T18090 pobj degradation,of
R11950 T18094 T18096 nmod [,]
R11951 T18095 T18096 nummod 77,]
R11952 T18096 T18093 appos ],degradation
R11953 T18097 T18071 punct .,bind
R11954 T18098 T18100 amod miR-146a,b
R11955 T18099 T18100 compound /,b
R11956 T18100 T18103 nsubj b,are
R11957 T18101 T18100 cc and,b
R11958 T18102 T18100 conj miR-155,b
R11959 T18103 T18103 ROOT are,are
R11960 T18104 T18103 prep of,are
R11961 T18105 T18106 amod particular,interest
R11962 T18106 T18104 pobj interest,of
R11963 T18107 T18103 prep for,are
R11964 T18108 T18109 amod inflammatory,signalling
R11965 T18109 T18107 pobj signalling,for
R11966 T18110 T18109 prep to,signalling
R11967 T18111 T18110 pobj NF-κB,to
R11968 T18112 T18103 punct ",",are
R11969 T18113 T18118 mark since,induced
R11970 T18114 T18115 det these,miRNAs
R11971 T18115 T18118 nsubjpass miRNAs,induced
R11972 T18116 T18118 aux can,induced
R11973 T18117 T18118 auxpass be,induced
R11974 T18118 T18103 advcl induced,are
R11975 T18119 T18118 agent by,induced
R11976 T18120 T18121 amod inflammatory,stimuli
R11977 T18121 T18119 pobj stimuli,by
R11978 T18122 T18123 amod such,as
R11979 T18123 T18121 prep as,stimuli
R11980 T18124 T18123 pobj IL-1β,as
R11981 T18125 T18124 punct ",",IL-1β
R11982 T18126 T18124 conj TNF,IL-1β
R11983 T18127 T18126 cc and,TNF
R11984 T18128 T18129 compound TLRs,[
R11985 T18129 T18126 conj [,TNF
R11986 T18130 T18131 compound "78,79",]
R11987 T18131 T18126 conj ],TNF
R11988 T18132 T18103 punct .,are
R11989 T18133 T18137 prep In,is
R11990 T18134 T18133 pobj addition,In
R11991 T18135 T18137 punct ",",is
R11992 T18136 T18137 nsubj miR-146a,is
R11993 T18137 T18137 ROOT is,is
R11994 T18138 T18140 det an,gene
R11995 T18139 T18140 amod NF-κB-dependent,gene
R11996 T18140 T18137 attr gene,is
R11997 T18141 T18137 punct ",",is
R11998 T18142 T18137 cc and,is
R11999 T18143 T18144 det the,NF-κB
R12000 T18144 T18145 nsubj NF-κB,signalling
R12001 T18145 T18151 advcl signalling,identified
R12002 T18146 T18145 dobj molecules,signalling
R12003 T18147 T18151 nsubjpass IRAK1,identified
R12004 T18148 T18147 cc and,IRAK1
R12005 T18149 T18147 conj TRAF6,IRAK1
R12006 T18150 T18151 auxpass were,identified
R12007 T18151 T18137 conj identified,is
R12008 T18152 T18151 prep as,identified
R12009 T18153 T18154 compound target,genes
R12010 T18154 T18152 pobj genes,as
R12011 T18155 T18154 prep of,genes
R12012 T18156 T18157 compound miR-146a,[
R12013 T18157 T18155 pobj [,of
R12014 T18158 T18159 nummod 78,]
R12015 T18159 T18154 conj ],genes
R12016 T18160 T18161 punct (,Figure
R12017 T18161 T18159 appos Figure,]
R12018 T18162 T18161 nummod 1,Figure
R12019 T18163 T18159 punct ),]
R12020 T18164 T18151 punct .,identified
R12021 T18165 T18169 advmod Similarly,shown
R12022 T18166 T18169 punct ",",shown
R12023 T18167 T18169 nsubjpass miR-155,shown
R12024 T18168 T18169 auxpass was,shown
R12025 T18169 T18169 ROOT shown,shown
R12026 T18170 T18171 aux to,target
R12027 T18171 T18169 xcomp target,shown
R12028 T18172 T18171 dobj transcripts,target
R12029 T18173 T18172 prep for,transcripts
R12030 T18174 T18175 det the,NF-κB
R12031 T18175 T18176 nsubj NF-κB,signalling
R12032 T18176 T18173 pcomp signalling,for
R12033 T18177 T18176 dobj molecules,signalling
R12034 T18178 T18176 dobj IKKε,signalling
R12035 T18179 T18178 cc and,IKKε
R12036 T18180 T18181 compound RIP1,[
R12037 T18181 T18178 conj [,IKKε
R12038 T18182 T18183 compound "79,80",]
R12039 T18183 T18178 conj ],IKKε
R12040 T18184 T18169 punct .,shown
R12041 T18185 T18192 advmod Notably,expressed
R12042 T18186 T18192 punct ",",expressed
R12043 T18187 T18188 preconj both,miR-146
R12044 T18188 T18192 nsubjpass miR-146,expressed
R12045 T18189 T18188 cc and,miR-146
R12046 T18190 T18188 conj miR-155,miR-146
R12047 T18191 T18192 auxpass are,expressed
R12048 T18192 T18192 ROOT expressed,expressed
R12049 T18193 T18192 prep at,expressed
R12050 T18194 T18195 amod higher,levels
R12051 T18195 T18193 pobj levels,at
R12052 T18196 T18195 prep in,levels
R12053 T18197 T18196 pobj RA,in
R12054 T18198 T18199 amod synovial,fibroblasts
R12055 T18199 T18195 conj fibroblasts,levels
R12056 T18200 T18199 cc and,fibroblasts
R12057 T18201 T18202 amod synovial,tissue
R12058 T18202 T18205 compound tissue,]
R12059 T18203 T18205 compound [,]
R12060 T18204 T18205 compound "81,82",]
R12061 T18205 T18199 conj ],fibroblasts
R12062 T18206 T18205 punct ",",]
R12063 T18207 T18209 advmod as,as
R12064 T18208 T18209 advmod well,as
R12065 T18209 T18193 cc as,at
R12066 T18210 T18209 prep in,as
R12067 T18211 T18214 amod peripheral,cells
R12068 T18212 T18213 compound blood,mononuclear
R12069 T18213 T18214 compound mononuclear,cells
R12070 T18214 T18210 pobj cells,in
R12071 T18215 T18214 prep of,cells
R12072 T18216 T18217 compound RA,patients
R12073 T18217 T18215 pobj patients,of
R12074 T18218 T18220 nmod [,]
R12075 T18219 T18220 nummod 83,]
R12076 T18220 T18192 dobj ],expressed
R12077 T18221 T18192 punct .,expressed
R12078 T18222 T18225 nsubjpass miR-146a,overexpressed
R12079 T18223 T18225 auxpass is,overexpressed
R12080 T18224 T18225 advmod also,overexpressed
R12081 T18225 T18225 ROOT overexpressed,overexpressed
R12082 T18226 T18225 prep in,overexpressed
R12083 T18227 T18228 compound CD4,+
R12084 T18228 T18226 pobj +,in
R12085 T18229 T18228 cc and,+
R12086 T18230 T18228 conj IL-17-producing,+
R12087 T18231 T18232 compound T,cells
R12088 T18232 T18225 conj cells,overexpressed
R12089 T18233 T18232 prep from,cells
R12090 T18234 T18235 compound RA,patients
R12091 T18235 T18233 pobj patients,from
R12092 T18236 T18237 quantmod [,"84,85"
R12093 T18237 T18238 nummod "84,85",]
R12094 T18238 T18232 conj ],cells
R12095 T18239 T18225 punct .,overexpressed
R12096 T18240 T18257 advmod Interestingly,shown
R12097 T18241 T18257 punct ",",shown
R12098 T18242 T18243 det a,polymorphism
R12099 T18243 T18257 nsubjpass polymorphism,shown
R12100 T18244 T18243 prep in,polymorphism
R12101 T18245 T18249 det the,UTR
R12102 T18246 T18249 nummod 3,UTR
R12103 T18247 T18246 punct ',3
R12104 T18248 T18249 punct -,UTR
R12105 T18249 T18244 pobj UTR,in
R12106 T18250 T18249 prep of,UTR
R12107 T18251 T18254 det the,gene
R12108 T18252 T18254 compound miR-146a,gene
R12109 T18253 T18254 compound target,gene
R12110 T18254 T18250 pobj gene,of
R12111 T18255 T18257 auxpass was,shown
R12112 T18256 T18257 advmod recently,shown
R12113 T18257 T18257 ROOT shown,shown
R12114 T18258 T18260 aux to,associated
R12115 T18259 T18260 auxpass be,associated
R12116 T18260 T18257 xcomp associated,shown
R12117 T18261 T18260 prep with,associated
R12118 T18262 T18263 compound RA,susceptibility
R12119 T18263 T18264 compound susceptibility,[
R12120 T18264 T18261 pobj [,with
R12121 T18265 T18266 nummod 86,]
R12122 T18266 T18264 appos ],[
R12123 T18267 T18257 punct .,shown
R12124 T18268 T18269 compound miR-155,overexpression
R12125 T18269 T18273 nsubj overexpression,was
R12127 T18271 T18272 amod synovial,fibroblasts
R12128 T18272 T18270 pobj fibroblasts,in
R12129 T18273 T18273 ROOT was,was
R12130 T18274 T18273 acomp able,was
R12131 T18275 T18276 aux to,prevent
R12132 T18276 T18274 xcomp prevent,able
R12133 T18277 T18278 det the,TLR
R12134 T18278 T18276 dobj TLR,prevent
R12135 T18279 T18278 cc and,TLR
R12136 T18280 T18281 amod cytokine-inducible,expression
R12137 T18281 T18278 conj expression,TLR
R12138 T18282 T18281 prep of,expression
R12139 T18283 T18285 amod specific,metalloproteinases
R12140 T18284 T18285 compound matrix,metalloproteinases
R12141 T18285 T18282 pobj metalloproteinases,of
R12142 T18286 T18287 nsubj that,mediate
R12143 T18287 T18285 relcl mediate,metalloproteinases
R12144 T18288 T18289 amod tissue,destruction
R12145 T18289 T18287 dobj destruction,mediate
R12146 T18290 T18287 prep in,mediate
R12147 T18291 T18292 compound RA,[
R12148 T18292 T18290 pobj [,in
R12149 T18293 T18294 nummod 81,]
R12150 T18294 T18292 appos ],[
R12151 T18295 T18273 punct .,was
R12152 T18296 T18300 advmod Moreover,shown
R12153 T18297 T18300 punct ",",shown
R12154 T18298 T18300 nsubjpass miR-155,shown
R12155 T18299 T18300 auxpass was,shown
R12156 T18300 T18300 ROOT shown,shown
R12157 T18301 T18302 aux to,promote
R12158 T18302 T18300 xcomp promote,shown
R12159 T18303 T18304 compound TNF,production
R12160 T18304 T18302 dobj production,promote
R12161 T18305 T18304 punct ",",production
R12162 T18306 T18308 det a,process
R12163 T18307 T18308 amod key,process
R12164 T18308 T18304 appos process,production
R12165 T18309 T18308 prep in,process
R12166 T18310 T18311 det the,pathogenesis
R12167 T18311 T18309 pobj pathogenesis,in
R12168 T18312 T18311 prep of,pathogenesis
R12169 T18313 T18314 compound RA,[
R12170 T18314 T18312 pobj [,of
R12171 T18315 T18316 nummod 87,]
R12172 T18316 T18311 appos ],pathogenesis
R12173 T18317 T18300 punct .,shown
R12174 T18318 T18323 nsubj miR-146,be
R12175 T18319 T18318 cc and,miR-146
R12176 T18320 T18318 conj miR-155,miR-146
R12177 T18321 T18323 aux may,be
R12178 T18322 T18323 advmod therefore,be
R12179 T18323 T18323 ROOT be,be
R12180 T18324 T18326 amod important,regulators
R12181 T18325 T18326 amod negative,regulators
R12182 T18326 T18323 attr regulators,be
R12183 T18327 T18326 prep of,regulators
R12184 T18328 T18327 pobj inflammation,of
R12185 T18329 T18328 prep in,inflammation
R12186 T18330 T18329 pobj RA,in
R12187 T18331 T18323 cc and,be
R12188 T18332 T18333 poss their,potential
R12189 T18333 T18340 nsubj potential,is
R12190 T18334 T18333 prep for,potential
R12191 T18335 T18336 det the,development
R12192 T18336 T18334 pobj development,for
R12193 T18337 T18336 prep of,development
R12194 T18338 T18339 amod new,treatments
R12195 T18339 T18337 pobj treatments,of
R12196 T18340 T18323 conj is,be
R12197 T18341 T18340 acomp substantial,is
R12198 T18342 T18340 punct .,is
R12199 T18343 T18352 prep In,is
R12200 T18344 T18343 pobj addition,In
R12201 T18345 T18352 punct ",",is
R12202 T18346 T18348 poss their,expression
R12203 T18347 T18348 amod increased,expression
R12204 T18348 T18352 nsubj expression,is
R12205 T18349 T18348 prep in,expression
R12206 T18350 T18351 compound RA,patients
R12207 T18351 T18349 pobj patients,in
R12208 T18352 T18352 ROOT is,is
R12209 T18353 T18354 advmod potentially,useful
R12210 T18354 T18352 acomp useful,is
R12211 T18355 T18354 prep as,useful
R12212 T18356 T18357 det a,marker
R12213 T18357 T18355 pobj marker,as
R12214 T18358 T18357 prep for,marker
R12215 T18359 T18360 compound disease,diagnosis
R12216 T18360 T18358 pobj diagnosis,for
R12217 T18361 T18360 punct ",",diagnosis
R12218 T18362 T18360 conj progression,diagnosis
R12219 T18363 T18362 punct ",",progression
R12220 T18364 T18362 cc or,progression
R12221 T18365 T18366 compound treatment,efficacy
R12222 T18366 T18362 conj efficacy,progression
R12223 T18367 T18369 nmod [,]
R12224 T18368 T18369 nummod 88,]
R12225 T18369 T18357 appos ],marker
R12226 T18370 T18352 punct ",",is
R12227 T18371 T18352 cc but,is
R12228 T18372 T18374 nsubj this,require
R12229 T18373 T18374 aux will,require
R12230 T18374 T18352 conj require,is
R12231 T18375 T18374 dobj confirmation,require
R12232 T18376 T18374 advcl using,require
R12233 T18377 T18381 det a,cohort
R12234 T18378 T18381 amod large,cohort
R12235 T18379 T18378 cc and,large
R12236 T18380 T18378 conj well-defined,large
R12237 T18381 T18376 dobj cohort,using
R12238 T18382 T18374 punct .,require
R12239 T18383 T18409 prep Besides,identified
R12240 T18384 T18383 pobj miR-146,Besides
R12241 T18385 T18384 cc and,miR-146
R12242 T18386 T18384 conj miR-155,miR-146
R12243 T18387 T18386 punct ",",miR-155
R12244 T18388 T18389 det a,number
R12245 T18389 T18386 appos number,miR-155
R12246 T18390 T18389 prep of,number
R12247 T18391 T18392 amod other,miRNAs
R12248 T18392 T18390 pobj miRNAs,of
R12249 T18393 T18389 prep with,number
R12250 T18394 T18396 det a,role
R12251 T18395 T18396 amod potential,role
R12252 T18396 T18393 pobj role,with
R12253 T18397 T18396 prep in,role
R12254 T18398 T18399 det the,control
R12255 T18399 T18397 pobj control,in
R12256 T18400 T18399 prep of,control
R12257 T18401 T18403 amod NF-κB-dependent,responses
R12258 T18402 T18403 amod inflammatory,responses
R12259 T18403 T18400 pobj responses,of
R12260 T18404 T18403 prep in,responses
R12261 T18405 T18406 compound RA,pathology
R12262 T18406 T18404 pobj pathology,in
R12263 T18407 T18409 auxpass were,identified
R12264 T18408 T18409 advmod recently,identified
R12265 T18409 T18409 ROOT identified,identified
R12266 T18410 T18409 punct .,identified
R12267 T18411 T18411 ROOT In,In
R12268 T18412 T18413 det this,context
R12269 T18413 T18411 pobj context,In
R12270 T18414 T18411 punct ",",In
R12271 T18415 T18411 conj miR-124a,In
R12272 T18416 T18415 punct -,miR-124a
R12273 T18417 T18419 det a,regulator
R12274 T18418 T18419 amod key,regulator
R12275 T18419 T18415 appos regulator,miR-124a
R12276 T18420 T18419 prep of,regulator
R12277 T18421 T18425 det the,protein
R12278 T18422 T18425 nmod chemokine,protein
R12279 T18423 T18425 nmod monocyte,protein
R12280 T18424 T18425 compound chemoattractant,protein
R12281 T18425 T18420 pobj protein,of
R12282 T18426 T18429 meta 1,shown
R12283 T18427 T18429 punct -,shown
R12284 T18428 T18429 auxpass was,shown
R12285 T18429 T18429 ROOT shown,shown
R12286 T18430 T18432 aux to,decreased
R12287 T18431 T18432 auxpass be,decreased
R12288 T18432 T18429 xcomp decreased,shown
R12289 T18433 T18432 prep in,decreased
R12290 T18434 T18433 pobj synoviocytes,in
R12291 T18435 T18434 prep from,synoviocytes
R12292 T18436 T18437 compound RA,patients
R12293 T18437 T18435 pobj patients,from
R12294 T18438 T18440 nmod [,]
R12295 T18439 T18440 nummod 89,]
R12296 T18440 T18437 appos ],patients
R12297 T18441 T18429 punct .,shown
R12298 T18442 T18460 advmod Similarly,detected
R12299 T18443 T18460 punct ",",detected
R12300 T18444 T18445 amod elevated,levels
R12301 T18445 T18460 nsubjpass levels,detected
R12302 T18446 T18445 prep of,levels
R12303 T18447 T18446 pobj miR-203,of
R12304 T18448 T18449 punct -,leading
R12305 T18449 T18445 acl leading,levels
R12306 T18450 T18449 prep to,leading
R12307 T18451 T18452 amod increased,secretion
R12308 T18452 T18450 pobj secretion,to
R12309 T18453 T18452 prep of,secretion
R12310 T18454 T18455 compound matrix,metalloproteinase-1
R12311 T18455 T18453 pobj metalloproteinase-1,of
R12312 T18456 T18455 cc and,metalloproteinase-1
R12313 T18457 T18455 conj IL-6,metalloproteinase-1
R12314 T18458 T18460 punct -,detected
R12315 T18459 T18460 auxpass were,detected
R12316 T18460 T18460 ROOT detected,detected
R12317 T18461 T18460 prep in,detected
R12318 T18462 T18464 nmod RA,fibroblasts
R12319 T18463 T18464 compound synovial,fibroblasts
R12320 T18464 T18465 compound fibroblasts,[
R12321 T18465 T18461 pobj [,in
R12322 T18466 T18467 nummod 90,]
R12323 T18467 T18465 appos ],[
R12324 T18468 T18460 punct .,detected
R12325 T18469 T18479 advmod Finally,shown
R12326 T18470 T18479 punct ",",shown
R12327 T18471 T18479 nsubjpass miR-16,shown
R12328 T18472 T18471 punct ",",miR-16
R12329 T18473 T18471 conj miR-132,miR-16
R12330 T18474 T18473 punct ",",miR-132
R12331 T18475 T18473 cc and,miR-132
R12332 T18476 T18473 conj miR-223,miR-132
R12333 T18477 T18479 auxpass were,shown
R12334 T18478 T18479 advmod also,shown
R12335 T18479 T18479 ROOT shown,shown
R12336 T18480 T18481 aux to,have
R12337 T18481 T18479 xcomp have,shown
R12338 T18482 T18484 det an,expression
R12339 T18483 T18484 amod altered,expression
R12340 T18484 T18481 dobj expression,have
R12341 T18485 T18484 prep in,expression
R12342 T18486 T18487 compound RA,patients
R12343 T18487 T18485 pobj patients,in
R12344 T18488 T18479 punct ",",shown
R12345 T18489 T18479 advcl indicating,shown
R12346 T18490 T18491 poss their,potential
R12347 T18491 T18489 dobj potential,indicating
R12348 T18492 T18491 prep as,potential
R12349 T18493 T18494 amod diagnostic,biomarkers
R12350 T18494 T18492 pobj biomarkers,as
R12351 T18495 T18494 prep for,biomarkers
R12352 T18496 T18495 pobj pathogenesis,for
R12353 T18497 T18499 compound [,]
R12354 T18498 T18499 compound "83,88,91",]
R12355 T18499 T18491 appos ],potential
R12356 T18500 T18479 punct .,shown
R12606 T19050 T19052 det The,family
R12607 T19051 T19052 compound NF-κB,family
R12608 T19052 T19056 nsubj family,plays
R12609 T19053 T19052 prep of,family
R12610 T19054 T19055 compound transcription,factors
R12611 T19055 T19053 pobj factors,of
R12612 T19056 T19056 ROOT plays,plays
R12613 T19057 T19058 amod crucial,roles
R12614 T19058 T19056 dobj roles,plays
R12615 T19059 T19056 prep in,plays
R12616 T19060 T19062 det the,processes
R12617 T19061 T19062 amod inflammatory,processes
R12618 T19062 T19059 pobj processes,in
R12619 T19063 T19062 prep in,processes
R12620 T19064 T19063 pobj RA,in
R12621 T19065 T19056 advcl leading,plays
R12622 T19066 T19065 prep to,leading
R12623 T19067 T19066 pobj cartilage,to
R12624 T19068 T19067 cc and,cartilage
R12625 T19069 T19070 compound bone,destruction
R12626 T19070 T19067 conj destruction,cartilage
R12627 T19071 T19056 punct .,plays
R12628 T19072 T19079 csubj Keeping,be
R12629 T19073 T19074 amod NF-κB,activation
R12630 T19074 T19072 dobj activation,Keeping
R12631 T19075 T19074 prep under,activation
R12632 T19076 T19075 pobj control,under
R12633 T19077 T19079 aux can,be
R12634 T19078 T19079 advmod thus,be
R12635 T19079 T19079 ROOT be,be
R12636 T19080 T19081 advmod very,important
R12637 T19081 T19079 acomp important,be
R12638 T19082 T19079 prep for,be
R12639 T19083 T19084 det the,design
R12640 T19084 T19082 pobj design,for
R12641 T19085 T19084 prep of,design
R12642 T19086 T19087 amod specific,therapeutics
R12643 T19087 T19085 pobj therapeutics,of
R12644 T19088 T19079 punct .,be
R12645 T19089 T19090 det The,existence
R12646 T19090 T19106 nsubj existence,raises
R12647 T19091 T19090 prep of,existence
R12648 T19092 T19094 amod multiple,regulators
R12649 T19093 T19094 amod negative,regulators
R12650 T19094 T19091 pobj regulators,of
R12651 T19095 T19090 acl ensuring,existence
R12652 T19096 T19098 det a,regulation
R12653 T19097 T19098 amod tight,regulation
R12654 T19098 T19095 dobj regulation,ensuring
R12655 T19099 T19098 prep of,regulation
R12656 T19100 T19102 det the,pathway
R12657 T19101 T19102 compound NF-κB,pathway
R12658 T19102 T19099 pobj pathway,of
R12659 T19103 T19098 punct ",",regulation
R12660 T19104 T19106 advmod however,raises
R12661 T19105 T19106 punct ",",raises
R12662 T19106 T19106 ROOT raises,raises
R12663 T19107 T19108 det the,question
R12664 T19108 T19106 dobj question,raises
R12665 T19109 T19108 prep of,question
R12666 T19110 T19112 det the,role
R12667 T19111 T19112 amod specific,role
R12668 T19112 T19109 pobj role,of
R12669 T19113 T19112 prep of,role
R12670 T19114 T19113 pobj each,of
R12671 T19115 T19114 prep of,each
R12672 T19116 T19117 det these,regulators
R12673 T19117 T19115 pobj regulators,of
R12674 T19118 T19114 cc and,each
R12675 T19119 T19120 det the,relationship
R12676 T19120 T19106 dobj relationship,raises
R12677 T19121 T19120 prep between,relationship
R12678 T19122 T19121 pobj them,between
R12679 T19123 T19106 punct .,raises
R12680 T19124 T19145 prep In,expected
R12681 T19125 T19124 pobj addition,In
R12682 T19126 T19145 punct ",",expected
R12683 T19127 T19145 prep given,expected
R12684 T19128 T19129 det the,number
R12685 T19129 T19127 pobj number,given
R12686 T19130 T19129 prep of,number
R12687 T19131 T19130 pobj miRNAs,of
R12688 T19132 T19131 prep in,miRNAs
R12689 T19133 T19132 pobj humans,in
R12690 T19134 T19129 cc and,number
R12691 T19135 T19137 det the,mRNAs
R12692 T19136 T19137 amod multiple,mRNAs
R12693 T19137 T19129 conj mRNAs,number
R12694 T19138 T19139 nsubj they,target
R12695 T19139 T19137 relcl target,mRNAs
R12696 T19140 T19145 punct ",",expected
R12697 T19141 T19142 amod intense,complexity
R12698 T19142 T19145 nsubjpass complexity,expected
R12699 T19143 T19145 aux can,expected
R12700 T19144 T19145 auxpass be,expected
R12701 T19145 T19145 ROOT expected,expected
R12702 T19146 T19145 punct .,expected
R12703 T19147 T19154 advmod How,regulated
R12704 T19148 T19151 predet all,signals
R12705 T19149 T19151 det these,signals
R12706 T19150 T19151 amod regulatory,signals
R12707 T19151 T19154 nsubjpass signals,regulated
R12708 T19152 T19154 auxpass are,regulated
R12709 T19153 T19154 npadvmod themselves,regulated
R12710 T19154 T19156 csubj regulated,be
R12711 T19155 T19156 aux will,be
R12712 T19156 T19156 ROOT be,be
R12713 T19157 T19159 det an,question
R12714 T19158 T19159 amod important,question
R12715 T19159 T19156 attr question,be
R12716 T19160 T19156 prep in,be
R12717 T19161 T19160 pobj order,in
R12718 T19162 T19163 aux to,clarify
R12719 T19163 T19161 acl clarify,order
R12720 T19164 T19167 advmod how,is
R12721 T19165 T19167 acomp NF-κB,is
R12722 T19166 T19167 nsubj signalling,is
R12723 T19167 T19163 ccomp is,clarify
R12724 T19168 T19167 attr organised,is
R12725 T19169 T19167 punct ",",is
R12726 T19170 T19167 cc and,is
R12727 T19171 T19167 punct ",",is
R12728 T19172 T19173 advmod more,importantly
R12729 T19173 T19179 advmod importantly,lead
R12730 T19174 T19179 punct ",",lead
R12731 T19175 T19179 advmod how,lead
R12732 T19176 T19177 det this,knowledge
R12733 T19177 T19179 nsubj knowledge,lead
R12734 T19178 T19179 aux may,lead
R12735 T19179 T19156 advcl lead,be
R12736 T19180 T19179 prep to,lead
R12737 T19181 T19182 amod new,treatments
R12738 T19182 T19180 pobj treatments,to
R12739 T19183 T19182 prep for,treatments
R12740 T19184 T19185 amod inflammatory,diseases
R12741 T19185 T19183 pobj diseases,for
R12742 T19186 T19187 amod such,as
R12743 T19187 T19185 prep as,diseases
R12744 T19188 T19187 pobj RA,as
R12745 T19189 T19156 punct .,be
R13295 T20179 T20180 compound Canonical,NF-κB
R13296 T20180 T20181 nsubj NF-κB,signalling
R13297 T20181 T20181 ROOT signalling,signalling
R13300 T20184 T20181 dobj regulators,signalling
R13301 T20185 T20181 punct .,signalling
R13302 T20186 T20187 compound Ligand,engagement
R13303 T20187 T20202 dep engagement,trigger
R13304 T20188 T20187 prep of,engagement
R13305 T20189 T20191 amod specific,receptors
R13306 T20190 T20191 compound membrane,receptors
R13307 T20191 T20188 pobj receptors,of
R13308 T20192 T20193 amod such,as
R13309 T20193 T20191 prep as,receptors
R13310 T20194 T20193 pobj TNFR1,as
R13311 T20195 T20194 punct ",",TNFR1
R13312 T20196 T20202 nsubj CD40,trigger
R13313 T20197 T20196 punct ",",CD40
R13314 T20198 T20196 conj RANK,CD40
R13315 T20199 T20198 punct ",",RANK
R13316 T20200 T20198 cc and,RANK
R13317 T20201 T20202 nummod TLR4,trigger
R13318 T20202 T20202 ROOT trigger,trigger
R13319 T20203 T20204 det the,recruitment
R13320 T20204 T20202 dobj recruitment,trigger
R13321 T20205 T20204 prep of,recruitment
R13322 T20206 T20208 amod specific,proteins
R13323 T20207 T20208 compound adaptor,proteins
R13324 T20208 T20205 pobj proteins,of
R13325 T20209 T20208 punct (,proteins
R13326 T20210 T20215 compound TNF,protein
R13327 T20211 T20215 compound receptor,protein
R13328 T20212 T20214 amod 1-associated,domain
R13329 T20213 T20214 compound death,domain
R13330 T20214 T20215 compound domain,protein
R13331 T20215 T20208 appos protein,proteins
R13332 T20216 T20217 punct (,TRADD
R13333 T20217 T20215 appos TRADD,protein
R13334 T20218 T20217 punct ),TRADD
R13335 T20219 T20215 punct ",",protein
R13336 T20220 T20215 appos MyD88,protein
R13337 T20221 T20220 punct ",",MyD88
R13338 T20222 T20220 conj MAL,MyD88
R13339 T20223 T20222 punct ",",MAL
R13340 T20224 T20227 compound TIR,IFNβ
R13341 T20225 T20227 compound domain-containing,IFNβ
R13342 T20226 T20227 compound adaptor-inducing,IFNβ
R13343 T20227 T20222 conj IFNβ,MAL
R13344 T20228 T20229 punct (,TRIF
R13345 T20229 T20227 appos TRIF,IFNβ
R13346 T20230 T20229 punct ),TRIF
R13347 T20231 T20227 punct ),IFNβ
R13348 T20232 T20227 punct ",",IFNβ
R13349 T20233 T20227 conj kinases,IFNβ
R13350 T20234 T20233 punct (,kinases
R13351 T20235 T20233 appos RIP1,kinases
R13352 T20236 T20233 punct ",",kinases
R13353 T20237 T20233 conj IRAK1,kinases
R13354 T20238 T20237 punct ",",IRAK1
R13355 T20239 T20237 conj IRAK4,IRAK1
R13356 T20240 T20237 punct ),IRAK1
R13357 T20241 T20237 punct ",",IRAK1
R13358 T20242 T20237 cc and,IRAK1
R13359 T20243 T20244 compound ubiquitin,ligases
R13360 T20244 T20237 conj ligases,IRAK1
R13361 T20245 T20244 punct (,ligases
R13362 T20246 T20244 appos TRAF2,ligases
R13363 T20247 T20246 punct ",",TRAF2
R13364 T20248 T20246 conj TRAF6,TRAF2
R13365 T20249 T20244 punct ",",ligases
R13366 T20250 T20244 conj cIAP1,ligases
R13367 T20251 T20250 punct ",",cIAP1
R13368 T20252 T20250 conj cIAP2,cIAP1
R13369 T20253 T20227 punct ),IFNβ
R13370 T20254 T20204 prep to,recruitment
R13371 T20255 T20256 det the,receptor
R13372 T20256 T20254 pobj receptor,to
R13373 T20257 T20202 punct .,trigger
R13374 T20258 T20259 amod K63-linked,polyubiquitination
R13375 T20259 T20268 nsubjpass polyubiquitination,recognised
R13380 T20264 T20263 cc and,RIP1
R13381 T20265 T20263 conj IRAK1,RIP1
R13382 T20266 T20268 punct ",",recognised
R13383 T20267 T20268 auxpass is,recognised
R13384 T20268 T20268 ROOT recognised,recognised
R13385 T20269 T20268 agent by,recognised
R13386 T20270 T20269 pobj NEMO,by
R13387 T20271 T20270 cc and,NEMO
R13388 T20272 T20270 conj TAB,NEMO
R13389 T20273 T20268 advcl proteins,recognised
R13390 T20274 T20268 punct ",",recognised
R13391 T20275 T20268 advcl resulting,recognised
R13392 T20276 T20275 prep in,resulting
R13393 T20277 T20278 det the,recruitment
R13394 T20278 T20276 pobj recruitment,in
R13395 T20279 T20278 cc and,recruitment
R13396 T20280 T20278 conj activation,recruitment
R13397 T20281 T20278 prep of,recruitment
R13398 T20282 T20283 advmod respectively,IKK2
R13399 T20283 T20275 npadvmod IKK2,resulting
R13400 T20284 T20283 cc and,IKK2
R13401 T20285 T20283 conj TAK1,IKK2
R13402 T20286 T20268 punct .,recognised
R13403 T20287 T20289 nummod TAK1,phosphorylates
R13404 T20288 T20289 advmod then,phosphorylates
R13405 T20289 T20289 ROOT phosphorylates,phosphorylates
R13406 T20290 T20289 cc and,phosphorylates
R13407 T20291 T20289 conj activates,phosphorylates
R13408 T20292 T20291 dobj IKK2,activates
R13409 T20293 T20292 punct ",",IKK2
R13410 T20294 T20300 dep which,triggering
R13411 T20295 T20294 prep in,which
R13412 T20296 T20295 pobj turn,in
R13413 T20297 T20298 compound phosphorylates,IκBα
R13414 T20298 T20295 pobj IκBα,in
R13415 T20299 T20300 punct ",",triggering
R13416 T20300 T20291 advcl triggering,activates
R13417 T20301 T20303 poss its,ubiquitination
R13418 T20302 T20303 compound K48-linked,ubiquitination
R13419 T20303 T20300 dobj ubiquitination,triggering
R13420 T20304 T20303 cc and,ubiquitination
R13421 T20305 T20306 amod proteasomal,degradation
R13422 T20306 T20303 conj degradation,ubiquitination
R13423 T20307 T20289 punct .,phosphorylates
R13424 T20308 T20309 nsubj This,allows
R13425 T20309 T20309 ROOT allows,allows
R13426 T20310 T20309 dobj NF-κB,allows
R13427 T20311 T20313 punct (,shown
R13428 T20312 T20313 advmod here,shown
R13429 T20313 T20310 parataxis shown,NF-κB
R13430 T20314 T20313 prep as,shown
R13431 T20315 T20316 det a,heterodimer
R13432 T20316 T20314 pobj heterodimer,as
R13433 T20317 T20316 prep of,heterodimer
R13434 T20318 T20317 pobj p65,of
R13435 T20319 T20318 cc and,p65
R13436 T20320 T20318 conj p50,p65
R13437 T20321 T20313 punct ),shown
R13438 T20322 T20310 advmod to,NF-κB
R13439 T20323 T20322 pobj translocate,to
R13440 T20324 T20323 prep to,translocate
R13441 T20325 T20326 det the,nucleus
R13442 T20326 T20324 pobj nucleus,to
R13443 T20327 T20323 cc and,translocate
R13444 T20328 T20323 conj promote,translocate
R13445 T20329 T20330 compound target,gene
R13446 T20330 T20331 compound gene,expression
R13447 T20331 T20328 dobj expression,promote
R13448 T20332 T20309 punct .,allows
R13449 T20333 T20344 dep TRAF1,regulate
R13450 T20334 T20333 punct ",",TRAF1
R13451 T20335 T20336 nsubj which,has
R13452 T20336 T20333 relcl has,TRAF1
R13453 T20337 T20340 det no,activity
R13454 T20338 T20340 compound ubiquitin,activity
R13455 T20339 T20340 compound ligase,activity
R13456 T20340 T20336 dobj activity,has
R13457 T20341 T20344 punct ",",regulate
R13458 T20342 T20344 aux can,regulate
R13459 T20343 T20344 advmod negatively,regulate
R13460 T20344 T20344 ROOT regulate,regulate
R13461 T20345 T20346 amod NF-κB,activation
R13462 T20346 T20344 dobj activation,regulate
R13463 T20347 T20344 punct ",",regulate
R13464 T20348 T20349 advmod most,probably
R13465 T20349 T20350 advmod probably,by
R13466 T20350 T20344 prep by,regulate
R13467 T20351 T20350 pcomp competing,by
R13468 T20352 T20351 prep with,competing
R13469 T20353 T20354 amod other,TRAFs
R13470 T20354 T20352 pobj TRAFs,with
R13471 T20355 T20344 punct .,regulate
R13472 T20356 T20360 nsubj A20,deubiquitinating
R13473 T20357 T20356 cc and,A20
R13474 T20358 T20356 conj CYLD,A20
R13475 T20359 T20360 aux are,deubiquitinating
R13476 T20360 T20360 ROOT deubiquitinating,deubiquitinating
R13477 T20361 T20360 dobj enzymes,deubiquitinating
R13478 T20362 T20363 nsubj that,control
R13479 T20363 T20361 relcl control,enzymes
R13480 T20364 T20365 amod NF-κB,activation
R13481 T20365 T20363 dobj activation,control
R13482 T20366 T20363 prep by,control
R13483 T20367 T20366 pcomp targeting,by
R13484 T20368 T20370 amod specific,proteins
R13485 T20369 T20370 amod signalling,proteins
R13486 T20370 T20367 dobj proteins,targeting
R13487 T20371 T20370 prep including,proteins
R13488 T20372 T20371 pobj RIP1,including
R13489 T20373 T20372 cc and,RIP1
R13490 T20374 T20372 conj TRAF6,RIP1
R13491 T20375 T20370 punct ",",proteins
R13492 T20376 T20380 prep to,recruited
R13493 T20377 T20376 pobj which,to
R13494 T20378 T20380 nsubjpass they,recruited
R13495 T20379 T20380 auxpass are,recruited
R13496 T20380 T20367 ccomp recruited,targeting
R13497 T20381 T20380 advcl using,recruited
R13498 T20382 T20385 amod specific,proteins
R13499 T20383 T20385 amod ubiquitin-binding,proteins
R13500 T20384 T20385 compound adaptor,proteins
R13501 T20385 T20381 dobj proteins,using
R13502 T20386 T20387 amod such,as
R13503 T20387 T20385 prep as,proteins
R13504 T20388 T20387 pobj ABIN-1,as
R13505 T20389 T20388 cc and,ABIN-1
R13506 T20390 T20388 conj p62,ABIN-1
R13507 T20391 T20360 punct .,deubiquitinating
R13508 T20392 T20394 nsubjpass miR-146,thought
R13509 T20393 T20394 auxpass is,thought
R13510 T20394 T20394 ROOT thought,thought
R13511 T20395 T20397 aux to,regulate
R13512 T20396 T20397 advmod negatively,regulate
R13513 T20397 T20394 xcomp regulate,thought
R13514 T20398 T20397 dobj TLR,regulate
R13515 T20399 T20397 oprd signalling,regulate
R13516 T20400 T20397 prep by,regulate
R13517 T20401 T20400 pcomp inhibiting,by
R13518 T20402 T20401 dobj expression,inhibiting
R13519 T20403 T20402 prep of,expression
R13520 T20404 T20403 pobj IRAK1,of
R13521 T20405 T20404 cc and,IRAK1
R13522 T20406 T20404 conj TRAF6,IRAK1
R13523 T20407 T20394 punct .,thought
R13524 T20408 T20415 advmod Finally,inhibited
R13525 T20409 T20415 punct ",",inhibited
R13526 T20410 T20411 compound TLR,signalling
R13527 T20411 T20415 nsubjpass signalling,inhibited
R13528 T20412 T20415 aux can,inhibited
R13529 T20413 T20415 advmod also,inhibited
R13530 T20414 T20415 auxpass be,inhibited
R13531 T20415 T20415 ROOT inhibited,inhibited
R13532 T20416 T20415 agent by,inhibited
R13533 T20417 T20419 det the,protein
R13534 T20418 T20419 compound transmembrane,protein
R13535 T20419 T20416 pobj protein,by
R13536 T20420 T20419 appos SIGIRR,protein
R13537 T20421 T20419 punct ",",protein
R13538 T20422 T20425 nsubjpass which,proposed
R13539 T20423 T20425 aux has,proposed
R13540 T20424 T20425 auxpass been,proposed
R13541 T20425 T20419 relcl proposed,protein
R13542 T20426 T20427 aux to,compete
R13543 T20427 T20425 xcomp compete,proposed
R13544 T20428 T20427 prep with,compete
R13545 T20429 T20428 pobj TLR4,with
R13546 T20430 T20429 prep for,TLR4
R13547 T20431 T20430 amod binding,for
R13548 T20432 T20431 prep to,binding
R13549 T20433 T20432 pobj IRAK1,to
R13550 T20434 T20433 cc and,IRAK1
R13551 T20435 T20433 conj TRAF6,IRAK1
R13552 T20436 T20415 punct .,inhibited
R13553 T20437 T20438 det The,expression
R13554 T20438 T20446 nsubj expression,is
R13555 T20439 T20438 prep of,expression
R13556 T20440 T20439 pobj many,of
R13557 T20441 T20440 prep of,many
R13558 T20442 T20445 det these,molecules
R13559 T20443 T20445 amod negative,molecules
R13560 T20444 T20445 amod regulatory,molecules
R13561 T20445 T20441 pobj molecules,of
R13562 T20446 T20446 ROOT is,is
R13563 T20447 T20448 advmod NF-κB,dependent
R13564 T20448 T20446 acomp dependent,is
R13565 T20449 T20446 punct ",",is
R13566 T20450 T20446 advcl implicating,is
R13567 T20451 T20450 dobj them,implicating
R13568 T20452 T20450 prep in,implicating
R13569 T20453 T20456 det the,regulation
R13570 T20454 T20456 amod negative,regulation
R13571 T20455 T20456 compound feedback,regulation
R13572 T20456 T20452 pobj regulation,in
R13573 T20457 T20456 prep of,regulation
R13574 T20458 T20459 amod NF-κB,activation
R13575 T20459 T20457 pobj activation,of
R13576 T20460 T20446 punct .,is
R13577 T20461 T20461 ROOT ABIN,ABIN
R13578 T20462 T20464 punct ",",inhibitor
R13579 T20463 T20464 amod A20-binding,inhibitor
R13580 T20464 T20461 appos inhibitor,ABIN
R13581 T20465 T20464 prep of,inhibitor
R13582 T20466 T20465 pobj NF-κB,of
R13583 T20467 T20461 punct ;,ABIN
R13584 T20468 T20461 conj cIAP,ABIN
R13585 T20469 T20468 punct ",",cIAP
R13586 T20470 T20471 amod cellular,inhibitor
R13587 T20471 T20468 appos inhibitor,cIAP
R13588 T20472 T20471 prep of,inhibitor
R13589 T20473 T20472 pobj apoptosis,of
R13590 T20474 T20468 punct ;,cIAP
R13591 T20475 T20468 conj CYLD,cIAP
R13592 T20476 T20475 punct ",",CYLD
R13593 T20477 T20475 appos cylindromatosis,CYLD
R13594 T20478 T20475 punct ;,CYLD
R13595 T20479 T20475 conj IKK,CYLD
R13596 T20480 T20479 punct ",",IKK
R13597 T20481 T20482 compound IκB,kinase
R13598 T20482 T20479 appos kinase,IKK
R13599 T20483 T20479 punct ;,IKK
R13600 T20484 T20479 conj IκB,IKK
R13601 T20485 T20484 punct ",",IκB
R13602 T20486 T20484 appos inhibitor,IκB
R13603 T20487 T20486 prep of,inhibitor
R13604 T20488 T20487 pobj NF-κB,of
R13605 T20489 T20484 punct ;,IκB
R13606 T20490 T20484 conj IRAK,IκB
R13607 T20491 T20490 punct ",",IRAK
R13608 T20492 T20493 amod IL-1R-associated,kinase
R13609 T20493 T20490 appos kinase,IRAK
R13610 T20494 T20490 punct ;,IRAK
R13611 T20495 T20490 conj MyD88,IRAK
R13617 T20501 T20495 appos gene,MyD88
R13618 T20502 T20501 nummod 88,gene
R13619 T20503 T20495 punct ;,MyD88
R13620 T20504 T20495 conj NEMO,MyD88
R13621 T20505 T20504 punct ",",NEMO
R13622 T20506 T20508 nmod NF-κB,modulator
R13623 T20507 T20508 amod essential,modulator
R13624 T20508 T20504 appos modulator,NEMO
R13625 T20509 T20504 punct ;,NEMO
R13626 T20510 T20504 conj NF,NEMO
R13627 T20511 T20510 punct ",",NF
R13628 T20512 T20513 amod nuclear,factor
R13629 T20513 T20510 appos factor,NF
R13630 T20514 T20510 punct ;,NF
R13631 T20515 T20510 conj RANK,NF
R13632 T20516 T20515 punct ",",RANK
R13633 T20517 T20518 compound receptor,activator
R13634 T20518 T20515 appos activator,RANK
R13635 T20519 T20518 prep of,activator
R13636 T20520 T20519 pobj NF-κB,of
R13637 T20521 T20461 punct ;,ABIN
R13638 T20522 T20461 conj RIP1,ABIN
R13639 T20523 T20522 punct ",",RIP1
R13640 T20524 T20526 compound receptor,protein
R13641 T20525 T20526 compound interacting,protein
R13642 T20526 T20461 appos protein,ABIN
R13643 T20527 T20526 nummod 1,protein
R13644 T20528 T20461 punct ;,ABIN
R13645 T20529 T20461 conj SIGIRR,ABIN
R13646 T20530 T20529 punct ",",SIGIRR
R13647 T20531 T20532 amod single-immunoglobulinIL-1,receptor-related
R13648 T20532 T20529 amod receptor-related,SIGIRR
R13649 T20533 T20529 punct ;,SIGIRR
R13650 T20534 T20529 conj TIR,SIGIRR
R13651 T20535 T20534 punct ",",TIR
R13652 T20536 T20537 compound Toll-like,receptor/IL
R13653 T20537 T20534 conj receptor/IL,TIR
R13654 T20538 T20539 nummod -1,R
R13655 T20539 T20556 ccomp R,factor
R13656 T20540 T20539 punct ;,R
R13657 T20541 T20544 npadvmod TRAF,receptor-associated
R13658 T20542 T20544 punct ",",receptor-associated
R13659 T20543 T20544 nsubj TNF,receptor-associated
R13660 T20544 T20556 ccomp receptor-associated,factor
R13661 T20545 T20544 dobj factor,receptor-associated
R13662 T20546 T20556 punct ;,factor
R13663 T20547 T20556 poss TLR,factor
R13664 T20548 T20550 punct ",",receptor
R13665 T20549 T20550 amod Toll-like,receptor
R13666 T20550 T20547 appos receptor,TLR
R13667 T20551 T20547 punct ;,TLR
R13668 T20552 T20547 conj TNF,TLR
R13669 T20553 T20552 punct ",",TNF
R13670 T20554 T20556 compound tumour,factor
R13671 T20555 T20556 compound necrosis,factor
R13672 T20556 T20556 ROOT factor,factor
R13673 T20557 T20556 punct .,factor
R14226 T21854 T21855 compound Noncanonical,NF-κB
R14227 T21855 T21855 ROOT NF-κB,NF-κB
R14228 T21856 T21855 acl signalling,NF-κB
R14229 T21857 T21856 punct .,signalling
R14230 T21858 T21858 ROOT CD40,CD40
R14231 T21859 T21858 cc and,CD40
R14232 T21860 T21862 nsubj RANK,activate
R14233 T21861 T21862 aux can,activate
R14234 T21862 T21858 conj activate,CD40
R14235 T21863 T21866 det the,pathway
R14236 T21864 T21866 amod noncanonical,pathway
R14237 T21865 T21866 compound NF-κB,pathway
R14238 T21866 T21862 dobj pathway,activate
R14239 T21867 T21868 nsubj that,is
R14240 T21868 T21866 relcl is,pathway
R14241 T21869 T21868 acomp dependent,is
R14242 T21870 T21869 prep on,dependent
R14243 T21871 T21872 nsubj NF-κB,inducing
R14244 T21872 T21870 pcomp inducing,on
R14245 T21873 T21878 nmod kinase,levels
R14246 T21874 T21878 punct (,levels
R14247 T21875 T21878 compound NIK,levels
R14248 T21876 T21877 punct ),expression
R14249 T21877 T21878 compound expression,levels
R14250 T21878 T21872 dobj levels,inducing
R14251 T21879 T21862 punct .,activate
R14252 T21880 T21884 prep In,forms
R14253 T21881 T21882 amod unstimulated,cells
R14254 T21882 T21880 pobj cells,In
R14255 T21883 T21884 nsubj NIK,forms
R14256 T21884 T21884 ROOT forms,forms
R14257 T21885 T21887 det a,complex
R14258 T21886 T21887 amod cytosolic,complex
R14259 T21887 T21884 dobj complex,forms
R14260 T21888 T21887 prep with,complex
R14261 T21889 T21890 det the,ubiquitin
R14262 T21890 T21891 nsubj ubiquitin,ligases
R14263 T21891 T21884 conj ligases,forms
R14264 T21892 T21891 dobj TRAF2,ligases
R14265 T21893 T21892 punct ",",TRAF2
R14266 T21894 T21892 conj TRAF3,TRAF2
R14267 T21895 T21894 cc and,TRAF3
R14268 T21896 T21894 conj cIAP1/2,TRAF3
R14269 T21897 T21896 punct ",",cIAP1/2
R14270 T21898 T21899 nsubj which,facilitates
R14271 T21899 T21896 relcl facilitates,cIAP1/2
R14272 T21900 T21902 det the,polyubiquitination
R14273 T21901 T21902 amod K48-linked,polyubiquitination
R14274 T21902 T21899 dobj polyubiquitination,facilitates
R14275 T21903 T21902 cc and,polyubiquitination
R14276 T21904 T21905 amod proteasomal,degradation
R14277 T21905 T21902 conj degradation,polyubiquitination
R14278 T21906 T21905 prep of,degradation
R14279 T21907 T21906 pobj NIK,of
R14280 T21908 T21891 punct ",",ligases
R14281 T21909 T21891 advcl keeping,ligases
R14282 T21910 T21911 compound NIK,levels
R14283 T21911 T21909 dobj levels,keeping
R14284 T21912 T21909 oprd low,keeping
R14285 T21913 T21891 punct .,ligases
R14286 T21914 T21916 mark Upon,binding
R14287 T21915 T21916 advmod ligand,binding
R14288 T21916 T21920 advcl binding,recruited
R14289 T21917 T21920 punct ",",recruited
R14290 T21918 T21920 nsubjpass TRAF3,recruited
R14291 T21919 T21920 auxpass is,recruited
R14292 T21920 T21920 ROOT recruited,recruited
R14293 T21921 T21920 prep to,recruited
R14294 T21922 T21923 det the,receptor
R14295 T21923 T21921 pobj receptor,to
R14296 T21924 T21923 punct ",",receptor
R14297 T21925 T21927 advmod where,directs
R14298 T21926 T21927 nummod TRAF2,directs
R14299 T21927 T21923 relcl directs,receptor
R14300 T21928 T21930 amod nondegradative,polyubiquitination
R14301 T21929 T21930 amod K63-linked,polyubiquitination
R14302 T21930 T21927 dobj polyubiquitination,directs
R14303 T21931 T21930 prep of,polyubiquitination
R14304 T21932 T21931 pobj cIAP1/2,of
R14305 T21933 T21927 punct ",",directs
R14306 T21934 T21920 advcl resulting,recruited
R14307 T21935 T21934 prep in,resulting
R14308 T21936 T21937 poss their,activation
R14309 T21937 T21935 pobj activation,in
R14310 T21938 T21920 punct .,recruited
R14311 T21939 T21941 advmod Subsequently,directs
R14312 T21940 T21941 nsubj cIAP1/2,directs
R14313 T21941 T21941 ROOT directs,directs
R14314 T21942 T21944 poss its,polyubiquitination
R14315 T21943 T21944 amod K48-linked,polyubiquitination
R14316 T21944 T21941 dobj polyubiquitination,directs
R14317 T21945 T21944 prep to,polyubiquitination
R14318 T21946 T21945 pobj TRAF3,to
R14319 T21947 T21944 punct ",",polyubiquitination
R14320 T21948 T21949 advmod rather,than
R14321 T21949 T21944 cc than,polyubiquitination
R14322 T21950 T21949 pobj NIK,than
R14323 T21951 T21941 punct .,directs
R14324 T21952 T21957 prep As,is
R14325 T21953 T21954 det a,result
R14326 T21954 T21952 pobj result,As
R14327 T21955 T21957 punct ",",is
R14328 T21956 T21957 nsubj TRAF3,is
R14329 T21957 T21957 ROOT is,is
R14330 T21958 T21957 acomp degraded,is
R14331 T21959 T21957 cc and,is
R14332 T21960 T21961 nsubj NIK,is
R14333 T21961 T21957 conj is,is
R14334 T21962 T21961 acomp stabilised,is
R14335 T21963 T21961 punct ",",is
R14336 T21964 T21961 advcl resulting,is
R14337 T21965 T21964 prep in,resulting
R14338 T21966 T21968 amod increased,levels
R14339 T21967 T21968 compound NIK,levels
R14340 T21968 T21965 pobj levels,in
R14341 T21969 T21968 prep in,levels
R14342 T21970 T21971 det the,cell
R14343 T21971 T21969 pobj cell,in
R14344 T21972 T21961 punct .,is
R14345 T21973 T21975 nsubj NIK,phosphorylates
R14346 T21974 T21975 advmod then,phosphorylates
R14347 T21975 T21975 ROOT phosphorylates,phosphorylates
R14348 T21976 T21975 cc and,phosphorylates
R14349 T21977 T21975 conj activates,phosphorylates
R14350 T21978 T21977 dobj IKK1,activates
R14351 T21979 T21978 punct ",",IKK1
R14352 T21980 T21981 nsubj which,mediates
R14353 T21981 T21978 relcl mediates,IKK1
R14354 T21982 T21984 nmod NF-κB,phosphorylation
R14355 T21983 T21984 nummod p100,phosphorylation
R14356 T21984 T21981 dobj phosphorylation,mediates
R14357 T21985 T21975 punct .,phosphorylates
R14358 T21986 T21988 nsubjpass This,followed
R14359 T21987 T21988 auxpass is,followed
R14360 T21988 T21988 ROOT followed,followed
R14361 T21989 T21988 agent by,followed
R14362 T21990 T21991 amod K48-linked,polyubiquitination
R14363 T21991 T21989 pobj polyubiquitination,by
R14364 T21992 T21991 cc and,polyubiquitination
R14365 T21993 T21995 amod partial,degradation
R14366 T21994 T21995 amod proteasomal,degradation
R14367 T21995 T21991 conj degradation,polyubiquitination
R14368 T21996 T21995 prep of,degradation
R14369 T21997 T21996 pobj p100,of
R14370 T21998 T21995 prep to,degradation
R14371 T21999 T21998 pobj p52,to
R14372 T22000 T21999 punct ",",p52
R14373 T22001 T22002 nsubj which,forms
R14374 T22002 T21999 relcl forms,p52
R14375 T22003 T22004 det a,heterodimer
R14376 T22004 T22002 dobj heterodimer,forms
R14377 T22005 T22004 prep with,heterodimer
R14378 T22006 T22005 pobj RelB,with
R14379 T22007 T22008 aux to,activate
R14380 T22008 T22002 advcl activate,forms
R14381 T22009 T22008 dobj transcription,activate
R14382 T22010 T21988 punct .,followed
R14383 T22011 T22019 advmod Next,identified
R14384 T22012 T22011 prep to,Next
R14385 T22013 T22012 pobj TRAF3,to
R14386 T22014 T22019 punct ",",identified
R14387 T22015 T22019 nsubjpass TRAF1,identified
R14388 T22016 T22019 aux has,identified
R14389 T22017 T22019 advmod also,identified
R14390 T22018 T22019 auxpass been,identified
R14391 T22019 T22019 ROOT identified,identified
R14392 T22020 T22019 prep as,identified
R14393 T22021 T22023 det a,regulator
R14394 T22022 T22023 amod negative,regulator
R14395 T22023 T22020 pobj regulator,as
R14396 T22024 T22023 prep of,regulator
R14397 T22025 T22026 det this,pathway
R14398 T22026 T22024 pobj pathway,of
R14399 T22027 T22023 punct ",",regulator
R14400 T22028 T22029 advmod most,probably
R14401 T22029 T22030 advmod probably,by
R14402 T22030 T22019 agent by,identified
R14403 T22031 T22030 pcomp competing,by
R14404 T22032 T22031 prep with,competing
R14405 T22033 T22036 amod other,factors
R14406 T22034 T22036 nmod TNF,factors
R14407 T22035 T22036 amod receptor-associated,factors
R14408 T22036 T22032 pobj factors,with
R14409 T22037 T22019 punct .,identified
R14410 T22038 T22038 ROOT cIAP,cIAP
R14411 T22039 T22038 punct ",",cIAP
R14412 T22040 T22041 amod cellular,inhibitor
R14413 T22041 T22038 appos inhibitor,cIAP
R14414 T22042 T22041 prep of,inhibitor
R14415 T22043 T22042 pobj apoptosis,of
R14416 T22044 T22038 punct ;,cIAP
R14417 T22045 T22038 conj IKK,cIAP
R14418 T22046 T22045 punct ",",IKK
R14419 T22047 T22048 compound IκB,kinase
R14420 T22048 T22045 appos kinase,IKK
R14421 T22049 T22045 punct ;,IKK
R14422 T22050 T22045 conj NF,IKK
R14423 T22051 T22050 punct ",",NF
R14424 T22052 T22053 amod nuclear,factor
R14425 T22053 T22050 appos factor,NF
R14426 T22054 T22050 punct ;,NF
R14427 T22055 T22050 conj RANK,NF
R14428 T22056 T22055 punct ",",RANK
R14429 T22057 T22058 compound receptor,activator
R14430 T22058 T22038 appos activator,cIAP
R14431 T22059 T22058 prep of,activator
R14432 T22060 T22059 pobj NF-κB,of
R14433 T22061 T22038 punct ;,cIAP
R14434 T22062 T22038 conj TRAF,cIAP
R14435 T22063 T22066 punct ",",factor
R14436 T22064 T22066 nmod TNF,factor
R14437 T22065 T22066 amod receptor-associated,factor
R14438 T22066 T22038 appos factor,cIAP
R14439 T22067 T22038 punct ;,cIAP
R14440 T22068 T22038 conj TNF,cIAP
R14441 T22069 T22068 punct ",",TNF
R14442 T22070 T22072 compound tumour,factor
R14443 T22071 T22072 compound necrosis,factor
R14444 T22072 T22038 appos factor,cIAP
R14445 T22073 T22038 punct .,cIAP
R8765 T13214 T13215 amod A20-binding,inhibitors
R10650 T16042 T16044 amod restricted,pattern
R10651 T16043 T16044 compound expression,pattern
R10652 T16044 T16039 pobj pattern,Because
R10653 T16045 T16049 punct ",",be
R10654 T16046 T16049 nsubj SIGIRR,be
R10655 T16047 T16049 aux may,be
R10656 T16048 T16049 advmod also,be
R10657 T16049 T16049 ROOT be,be
R10658 T16050 T16053 det an,target
R10659 T16051 T16053 amod interesting,target
R10660 T16052 T16053 amod therapeutic,target
R10661 T16053 T16049 attr target,be
R10662 T16054 T16049 prep in,be
R10663 T16055 T16054 pobj RA,in
R10664 T16056 T16049 punct .,be
R9041 T13490 T13486 pobj proteins,of
R11067 T16789 T16788 prep of,modulator
R11068 T16790 T16791 amod NF-κB,signalling
R11069 T16791 T16789 pobj signalling,of
R11070 T16792 T16791 prep by,signalling
R11071 T16793 T16796 amod certain,receptors
R11072 T16794 T16796 compound TNF,receptors
R11073 T16795 T16796 compound family,receptors
R11074 T16796 T16792 pobj receptors,by
R11075 T16797 T16796 punct ",",receptors
R11076 T16798 T16799 advmod possibly,in
R11077 T16799 T16788 prep in,modulator
R11078 T16800 T16802 det a,manner
R11079 T16801 T16802 amod cell-type-dependent,manner
R11080 T16802 T16799 pobj manner,in
R11081 T16803 T16805 compound [,]
R11082 T16804 T16805 compound "71,72",]
R11083 T16805 T16802 appos ],manner
R11084 T16806 T16776 punct .,support
R11085 T16807 T16810 nsubj Expression,is
R11086 T16808 T16807 prep of,Expression
R11087 T16809 T16808 pobj TRAF1,of
R11088 T16810 T16810 ROOT is,is
R11089 T16811 T16810 acomp inducible,is
R11090 T16812 T16811 prep by,inducible
R11091 T16813 T16812 pobj TNF,by
R11121 T16843 T16844 advmod also,functions
R11277 T16999 T16997 pobj [,with
R11278 T17000 T17001 nummod 76,]
R12126 T18270 T18269 prep in,overexpression
R13298 T20182 T20181 cc and,signalling
R13299 T20183 T20184 amod negative,regulators
R13376 T20260 T20259 prep of,polyubiquitination
R13377 T20261 T20260 pobj TRAFs,of
R13378 T20262 T20261 punct ",",TRAFs
R13379 T20263 T20261 conj RIP1,TRAFs
R13612 T20496 T20495 punct ",",MyD88
R13613 T20497 T20498 amod myeloid,differentiation
R13614 T20498 T20501 nmod differentiation,gene
R13615 T20499 T20501 amod primary,gene
R13616 T20500 T20501 compound response,gene
R9950 T14928 T14929 compound adaptor,protein
R9951 T14929 T14925 pobj protein,via
R9952 T14930 T14921 conj p62,recruited
R9953 T14931 T14933 punct (,known
R9954 T14932 T14933 advmod also,known
R10024 T15002 T15001 dobj CYLD,indicate
R10025 T15003 T15001 prep as,indicate
R10026 T15004 T15007 det a,factor
R10027 T15005 T15007 amod potential,factor
R10028 T15006 T15007 amod genetic,factor
R4000 T5957 T5956 pobj IκBs,of
R4002 T5958 T5973 punct (,p100
R4003 T5959 T5973 nmod IκBα,p100
R4005 T5960 T5959 punct ",",IκBα
R4006 T5961 T5959 conj IκBβ,IκBα
R4071 T6054 T6055 amod many,stimuli
R4079 T6055 T6053 pobj stimuli,by
R4084 T6056 T6055 prep including,stimuli

DLUT931

Id Subject Object Predicate Lexical cue
T22211 15004-15013 Negative_regulation denotes inhibitor
T22210 14891-14900 Regulation denotes regulator
T22209 14782-14793 Binding denotes heterodimer
T22208 14740-14751 Protein_catabolism denotes degradation
T22207 14649-14664 Phosphorylation denotes phosphorylation
T22206 14629-14637 Positive_regulation denotes mediates
T22205 14607-14616 Positive_regulation denotes activates
T22204 14545-14554 Positive_regulation denotes increased
T22203 14532-14541 Positive_regulation denotes resulting
T22202 14520-14530 Positive_regulation denotes stabilised
T22201 14500-14508 Protein_catabolism denotes degraded
T22200 14432-14450 Binding denotes polyubiquitination
T22199 14292-14299 Negative_regulation denotes directs
T22198 14326-14344 Positive_regulation denotes polyubiquitination
T22197 14300-14314 Protein_catabolism denotes nondegradative
T22196 14253-14262 Binding denotes recruited
T22195 14117-14128 Positive_regulation denotes facilitates
T22194 14218-14221 Positive_regulation denotes low
T22193 14179-14190 Protein_catabolism denotes degradation
T22192 14144-14162 Binding denotes polyubiquitination
T22191 13946-13955 Regulation denotes dependent
T22190 13987-13997 Gene_expression denotes expression
T22189 15143-15165 Protein denotes tumour necrosis factor
T22188 15138-15141 Protein denotes TNF
T22187 15071-15098 Protein denotes receptor activator of NF-κB
T22186 15065-15069 Protein denotes RANK
T22185 14846-14851 Protein denotes TRAF1
T22184 14839-14844 Protein denotes TRAF3
T22183 14799-14803 Protein denotes RelB
T22182 14763-14766 Protein denotes p52
T22181 14755-14759 Protein denotes p100
T22180 14644-14648 Protein denotes p100
T22179 14617-14621 Protein denotes IKK1
T22178 14579-14582 Protein denotes NIK
T22177 14555-14558 Protein denotes NIK
T22176 14513-14516 Protein denotes NIK
T22175 14491-14496 Protein denotes TRAF3
T22174 14473-14476 Protein denotes NIK
T22173 14454-14459 Protein denotes TRAF3
T22172 14407-14408 Protein denotes 2
T22171 14401-14406 Protein denotes cIAP1
T22170 14354-14355 Protein denotes 2
T22169 14348-14353 Protein denotes cIAP1
T22168 14286-14291 Protein denotes TRAF2
T22167 14244-14249 Protein denotes TRAF3
T22166 14108-14109 Protein denotes 2
T22165 14102-14107 Protein denotes cIAP1
T22164 14092-14097 Protein denotes TRAF3
T22163 14085-14090 Protein denotes TRAF2
T22162 14028-14031 Protein denotes NIK
T22161 14207-14210 Protein denotes NIK
T22160 14194-14197 Protein denotes NIK
T22159 13982-13985 Protein denotes NIK
T22158 13959-13980 Protein denotes NF-κB inducing kinase
T22157 13889-13893 Protein denotes RANK
T22156 13880-13884 Protein denotes CD40
T20674 8787-8792 Protein denotes MyD88
T20673 8779-8784 Protein denotes TRADD
T20672 8731-8777 Protein denotes TNF receptor 1-associated death domain protein
T20671 8672-8676 Protein denotes TLR4
T20670 8662-8666 Protein denotes RANK
T20669 8656-8660 Protein denotes CD40
T20668 8926-8931 Protein denotes cIAP2
T20667 8919-8924 Protein denotes cIAP1
T20666 8912-8917 Protein denotes TRAF6
T20665 8905-8910 Protein denotes TRAF2
T20664 8874-8879 Protein denotes IRAK4
T20663 8867-8872 Protein denotes IRAK1
T20662 8861-8865 Protein denotes RIP1
T20661 8844-8848 Protein denotes TRIF
T20660 8649-8654 Protein denotes TNFR1
T20726 10010-10017 Binding denotes binding
T20725 9988-9995 Binding denotes compete
T20724 9836-9846 Negative_regulation denotes inhibiting
T20723 9847-9857 Gene_expression denotes expression
T20722 9692-9701 Binding denotes recruited
T20721 9306-9317 Binding denotes heterodimer
T20720 9180-9194 Phosphorylation denotes phosphorylates
T20719 9150-9159 Positive_regulation denotes activates
T20718 9079-9089 Positive_regulation denotes activation
T20717 9063-9074 Binding denotes recruitment
T20716 8961-8979 Ubiquitination denotes polyubiquitination
T20715 10701-10723 Protein denotes tumour necrosis factor
T20714 10696-10699 Protein denotes TNF
T20713 10558-10600 Protein denotes single-immunoglobulinIL-1 receptor-related
T20712 10550-10556 Protein denotes SIGIRR
T20711 10518-10548 Protein denotes receptor interacting protein 1
T20710 10512-10516 Protein denotes RIP1
T20709 10483-10510 Protein denotes receptor activator of NF-κB
T20708 10477-10481 Protein denotes RANK
T20707 10430-10455 Protein denotes NF-κB essential modulator
T20706 10424-10428 Protein denotes NEMO
T20705 10374-10422 Protein denotes myeloid differentiation primary response gene 88
T20704 10367-10372 Protein denotes MyD88
T20703 10277-10292 Protein denotes cylindromatosis
T20702 10271-10275 Protein denotes CYLD
T20701 10200-10230 Protein denotes A20-binding inhibitor of NF-κB
T20700 10194-10198 Protein denotes ABIN
T20699 10031-10036 Protein denotes TRAF6
T20698 10021-10026 Protein denotes IRAK1
T20697 10001-10005 Protein denotes TLR4
T20696 9953-9959 Protein denotes SIGIRR
T20695 9871-9876 Protein denotes TRAF6
T20694 9861-9866 Protein denotes IRAK1
T20693 9771-9774 Protein denotes p62
T20692 9760-9766 Protein denotes ABIN-1
T20691 9667-9672 Protein denotes TRAF6
T20690 9658-9662 Protein denotes RIP1
T20689 9542-9546 Protein denotes CYLD
T20688 9534-9537 Protein denotes A20
T20687 9400-9405 Protein denotes TRAF1
T20686 9329-9332 Protein denotes p50
T20685 9321-9324 Protein denotes p65
T20684 9195-9199 Protein denotes IκBα
T20683 9160-9164 Protein denotes IKK2
T20682 9121-9125 Protein denotes TAK1
T20681 9115-9119 Protein denotes TAK1
T20680 9106-9110 Protein denotes IKK2
T20679 9023-9027 Protein denotes NEMO
T20678 8999-9004 Protein denotes IRAK1
T20677 8990-8994 Protein denotes RIP1
T20676 8799-8842 Protein denotes TIR domain-containing adaptor-inducing IFNβ
T20675 8794-8797 Protein denotes MAL
T18593 32702-32712 Gene_expression denotes expression
T18592 32521-32530 Positive_regulation denotes increased
T18591 32510-32517 Positive_regulation denotes leading
T18590 32531-32540 Localization denotes secretion
T18589 32421-32430 Negative_regulation denotes decreased
T18588 32341-32350 Regulation denotes regulator
T18587 31672-31679 Positive_regulation denotes promote
T18586 31684-31694 Gene_expression denotes production
T18585 31458-31472 Positive_regulation denotes overexpression
T18584 31269-31278 Gene_expression denotes producing
T18583 31237-31250 Gene_expression denotes overexpressed
T18582 31067-31076 Gene_expression denotes expressed
T18581 30786-30801 Regulation denotes NF-κB-dependent
T18580 32659-32666 Protein denotes miR-223
T18579 32646-32653 Protein denotes miR-132
T18578 32638-32644 Protein denotes miR-16
T18577 32575-32579 Protein denotes IL-6
T18576 32544-32570 Protein denotes matrix metalloproteinase-1
T18575 32500-32507 Protein denotes miR-203
T18574 32368-32402 Protein denotes monocyte chemoattractant protein 1
T18573 32324-32332 Protein denotes miR-124a
T18572 32152-32159 Protein denotes miR-155
T18571 31754-31761 Protein denotes miR-155
T18564 31220-31228 Protein denotes miR-146a
T18563 31055-31062 Protein denotes miR-155
T18562 31015-31019 Protein denotes RIP1
T18561 31006-31010 Protein denotes IKKε
T18560 30931-30938 Protein denotes miR-155
T18559 30894-30902 Protein denotes miR-146a
T18558 30853-30858 Protein denotes TRAF6
T18557 30843-30848 Protein denotes IRAK1
T18556 30771-30779 Protein denotes miR-146a
T18555 30736-30739 Protein denotes TNF
T18554 30729-30734 Protein denotes IL-1β
T18553 30590-30597 Protein denotes miR-155
T18552 30584-30585 Protein denotes b
T18551 30575-30583 Protein denotes miR-146a
T17070 30171-30182 Binding denotes association
T17069 29761-29769 Binding denotes interact
T17068 29720-29727 Binding denotes recruit
T17067 29639-29646 Binding denotes binding
T17066 29336-29345 Negative_regulation denotes deficient
T17065 29128-29137 Negative_regulation denotes deficient
T17064 29059-29073 Positive_regulation denotes overexpression
T17063 29038-29047 Positive_regulation denotes inducible
T17062 29015-29025 Gene_expression denotes Expression
T17061 30190-30195 Protein denotes TRAF1
T17060 30057-30062 Protein denotes TRAF1
T17059 29955-29960 Protein denotes TRAF1
T17058 29728-29731 Protein denotes A20
T17057 29708-29713 Protein denotes TRAF1
T17056 29595-29600 Protein denotes TRAF1
T17055 29528-29533 Protein denotes TRAF1
T17054 29426-29431 Protein denotes TRAF2
T17053 29330-29335 Protein denotes TRAF1
T17052 29299-29303 Protein denotes CD40
T17051 29251-29256 Protein denotes TRAF1
T17050 29122-29127 Protein denotes TRAF1
T17049 29170-29173 Protein denotes TNF
T17048 29092-29095 Protein denotes TNF
T17047 29077-29082 Protein denotes TRAF1
T17046 29051-29054 Protein denotes TNF
T17045 29029-29034 Protein denotes TRAF1
T17044 28862-28867 Protein denotes TRAF1
T17043 28798-28807 Protein denotes ubiquitin
T17042 28688-28693 Protein denotes TRAF1
T17041 28655-28687 Protein denotes TNF receptor-associated factor 1
T16109 28574-28584 Gene_expression denotes expression
T16108 28520-28531 Negative_regulation denotes compromised
T16107 28391-28401 Gene_expression denotes expression
T16106 28219-28228 Negative_regulation denotes deficient
T16105 28026-28040 Positive_regulation denotes overexpression
T16104 27898-27907 Gene_expression denotes expressed
T16103 27872-27882 Gene_expression denotes expression
T16102 27616-27627 Binding denotes interaction
T16101 27553-27562 Negative_regulation denotes inhibitor
T16100 28594-28600 Protein denotes SIGIRR
T16099 28510-28516 Protein denotes SIGIRR
T16098 28405-28411 Protein denotes SIGIRR
T16097 28212-28218 Protein denotes SIGIRR
T16096 28168-28174 Protein denotes SIGIRR
T16095 28019-28025 Protein denotes SIGIRR
T16094 27843-27849 Protein denotes SIGIRR
T16093 27717-27722 Protein denotes IL-1R
T16092 27813-27819 Protein denotes SIGIRR
T16091 27666-27671 Protein denotes TRAF6
T16090 27657-27662 Protein denotes IRAK1
T16089 27650-27655 Protein denotes MyD88
T16088 27566-27571 Protein denotes IL-1R
T16087 27464-27469 Protein denotes TIR-8
T16086 27433-27439 Protein denotes SIGIRR
T16085 27388-27431 Protein denotes Single-immunoglobulin IL-1 receptor-related
T16084 27336-27379 Protein denotes Single-immunoglobulin IL-1 receptor-related
T15108 26635-26645 Gene_expression denotes expression
T15107 26406-26416 Negative_regulation denotes deficiency
T15106 25997-26006 Gene_expression denotes expressed
T15105 27244-27248 Protein denotes CYLD
T15104 27135-27139 Protein denotes RANK
T15103 27106-27110 Protein denotes CYLD
T15102 26993-26996 Protein denotes p62
T15101 26896-26901 Protein denotes TRAF6
T15100 26862-26866 Protein denotes CYLD
T15099 26824-26838 Protein denotes sequestosome 1
T15098 26805-26808 Protein denotes p62
T15097 26771-26780 Protein denotes ubiquitin
T15096 26757-26762 Protein denotes TRAF6
T15095 26690-26695 Protein denotes RANKL
T15094 26630-26634 Protein denotes CYLD
T15093 26559-26564 Protein denotes RANKL
T15092 26420-26424 Protein denotes CYLD
T15091 26333-26337 Protein denotes RANK
T15090 26290-26294 Protein denotes CYLD
T15089 26143-26147 Protein denotes CYLD
T15088 25985-25988 Protein denotes A20
T15087 25948-25952 Protein denotes CYLD
T15086 25933-25936 Protein denotes A20
T15085 25884-25887 Protein denotes A20
T15084 25813-25818 Protein denotes TRAF2
T15083 25807-25811 Protein denotes NEMO
T15082 25674-25678 Protein denotes RANK
T15081 25588-25611 Protein denotes deubiquitinating enzyme
T15080 25578-25582 Protein denotes CYLD
T15079 25843-25847 Protein denotes TAK1
T15078 25834-25838 Protein denotes RIP1
T15077 25827-25832 Protein denotes TRAF7
T15076 25820-25825 Protein denotes TRAF6
T15075 25385-25389 Protein denotes CYLD
T15074 25279-25283 Protein denotes CYLD
T15073 25262-25277 Protein denotes Cylindromatosis
T15072 25238-25253 Protein denotes Cylindromatosis
T15114 26964-26974 Gene_expression denotes expressing
T15113 26876-26892 Negative_regulation denotes deubiquitination
T15112 26781-26788 Binding denotes binding
T15111 26743-26756 Positive_regulation denotes ubiquitinated
T15110 26730-26739 Binding denotes recruited
T15109 26658-26669 Positive_regulation denotes upregulated
T13722 24468-24474 Regulation denotes depend
T13721 24482-24492 Gene_expression denotes expression
T13720 23922-23931 Negative_regulation denotes deficient
T13719 23874-23882 Negative_regulation denotes inhibits
T13718 23790-23797 Negative_regulation denotes lacking
T13717 23810-23827 Binding denotes ubiquitin-binding
T13716 23752-23759 Gene_expression denotes express
T13715 23717-23726 Gene_expression denotes expressed
T13714 23523-23532 Negative_regulation denotes deficient
T13713 23502-23511 Negative_regulation denotes deficient
T13712 23335-23344 Regulation denotes dependent
T13711 23315-23325 Gene_expression denotes expression
T13710 23229-23235 Binding denotes target
T13709 23013-23024 Binding denotes interacting
T13708 22999-23008 Gene_expression denotes expressed
T13707 22878-22888 Negative_regulation denotes inhibitors
T13706 22870-22877 Binding denotes binding
T13705 24679-24685 Protein denotes ABIN-1
T13704 24537-24540 Protein denotes A20
T13703 24526-24532 Protein denotes ABIN-3
T13702 24239-24242 Protein denotes A20
T13701 24217-24223 Protein denotes ABIN-1
T13700 24136-24142 Protein denotes ABIN-1
T13699 24076-24079 Protein denotes TNF
T13698 24048-24054 Protein denotes ABIN-1
T13697 23962-23965 Protein denotes TNF
T13696 23915-23921 Protein denotes ABIN-1
T13695 23883-23886 Protein denotes TNF
T13694 23853-23859 Protein denotes ABIN-1
T13693 23848-23851 Protein denotes A20
T13692 23762-23789 Protein denotes truncated and inactive form
T13691 23707-23713 Protein denotes ABIN-3
T13690 23516-23522 Protein denotes ABIN-2
T13689 23495-23501 Protein denotes ABIN-1
T13688 23383-23386 Protein denotes A20
T13687 23308-23314 Protein denotes ABIN-3
T13686 23297-23303 Protein denotes ABIN-1
T13685 23292-23295 Protein denotes A20
T13684 23236-23239 Protein denotes A20
T13683 23080-23083 Protein denotes TNF
T13682 23009-23012 Protein denotes A20
T13681 22959-22965 Protein denotes TNIP-3
T13680 22947-22953 Protein denotes TNIP-2
T13679 22939-22945 Protein denotes TNIP-1
T13678 22917-22923 Protein denotes ABIN-3
T13677 22906-22912 Protein denotes ABIN-2
T13676 22898-22904 Protein denotes ABIN-1
T13675 22866-22869 Protein denotes A20
T11919 22545-22554 Negative_regulation denotes repressed
T11918 22559-22572 Transcription denotes transcription
T11917 22313-22319 Regulation denotes affect
T11916 21811-21820 Negative_regulation denotes mutations
T11915 21791-21802 Binding denotes association
T11914 21456-21460 Negative_regulation denotes lack
T11913 21166-21180 Positive_regulation denotes overexpression
T11912 21017-21027 Gene_expression denotes transduced
T11911 20970-20979 Negative_regulation denotes decreased
T11910 20586-20595 Negative_regulation denotes decreased
T11909 20503-20513 Gene_expression denotes expression
T11908 20275-20285 Gene_expression denotes expressing
T11907 20131-20140 Regulation denotes regulated
T11906 20110-20120 Gene_expression denotes expression
T11905 19933-19943 Gene_expression denotes expression
T11904 19790-19797 Negative_regulation denotes lacking
T11903 19475-19482 Negative_regulation denotes lacking
T11902 19315-19324 Negative_regulation denotes deficient
T11901 19130-19139 Negative_regulation denotes deficient
T11900 18985-18994 Negative_regulation denotes inhibitor
T11899 18774-18782 Positive_regulation denotes requires
T11898 18792-18809 Binding denotes ubiquitin-binding
T11897 18766-18773 Regulation denotes targets
T11896 18738-18749 Binding denotes association
T11895 22791-22794 Protein denotes A20
T11894 22555-22558 Protein denotes A20
T11893 22507-22510 Protein denotes A20
T11892 22327-22330 Protein denotes A20
T11891 22246-22249 Protein denotes A20
T11890 22208-22216 Protein denotes cytokine
T11889 22176-22179 Protein denotes TNF
T11888 22151-22154 Protein denotes TNF
T11887 22116-22119 Protein denotes A20
T11886 22029-22032 Protein denotes A20
T11885 21982-21985 Protein denotes A20
T11884 21828-21831 Protein denotes A20
T11883 21607-21610 Protein denotes A20
T11882 21461-21464 Protein denotes A20
T11881 21257-21260 Protein denotes A20
T11880 21162-21165 Protein denotes A20
T11879 21013-21016 Protein denotes A20
T11878 21004-21009 Protein denotes IL-1β
T11877 20996-20999 Protein denotes TNF
T11876 20869-20874 Protein denotes IL-1β
T11875 20861-20864 Protein denotes TNF
T11874 20703-20706 Protein denotes A20
T11873 20639-20674 Protein denotes monocyte chemo-attractant protein 1
T11872 20632-20637 Protein denotes RANKL
T11871 20618-20622 Protein denotes IL-6
T11870 20611-20616 Protein denotes IL-1β
T11869 20606-20609 Protein denotes TNF
T11868 20499-20502 Protein denotes A20
T11867 20271-20274 Protein denotes A20
T11866 20168-20171 Protein denotes A20
T11865 20106-20109 Protein denotes A20
T11864 19929-19932 Protein denotes A20
T11863 19798-19801 Protein denotes A20
T11862 19677-19680 Protein denotes A20
T11861 19643-19646 Protein denotes TNF
T11860 19483-19486 Protein denotes A20
T11859 19360-19363 Protein denotes TNF
T11858 19311-19314 Protein denotes A20
T11857 19126-19129 Protein denotes A20
T11856 19062-19065 Protein denotes A20
T11855 18964-18967 Protein denotes A20
T11854 18882-18904 Protein denotes Tax1-binding protein 1
T11853 18838-18877 Protein denotes A20-binding inhibitor of NF-κB (ABIN) 1
T11852 18753-18756 Protein denotes A20
T11851 18691-18694 Protein denotes A20
T11850 18634-18635 Protein denotes 2
T11849 18628-18633 Protein denotes cIAP1
T11848 18618-18623 Protein denotes TRAF2
T11847 18611-18616 Protein denotes TRAF6
T11846 18577-18583 Protein denotes Ubc5hc
T11845 18567-18572 Protein denotes Ubc13
T11844 18388-18392 Protein denotes RIP2
T11843 18382-18386 Protein denotes RIP1
T11842 18275-18278 Protein denotes A20
T11841 18404-18409 Protein denotes MALT1
T11840 18394-18399 Protein denotes TRAF6
T11839 18132-18135 Protein denotes TNF
T11838 18038-18043 Protein denotes NF-κB
T11837 17986-18011 Protein denotes ubiquitin-editing protein
T11836 17972-17979 Protein denotes TNFAIP3
T11835 17953-17956 Protein denotes A20
T11834 17941-17944 Protein denotes A20
T9170 17665-17679 Phosphorylation denotes phosphorylates
T9169 17580-17595 Phosphorylation denotes phosphorylating
T9168 17428-17436 Positive_regulation denotes enhanced
T9167 17418-17424 Positive_regulation denotes result
T9166 17462-17473 Protein_catabolism denotes degradation
T9165 17442-17452 Positive_regulation denotes activation
T9164 17344-17352 Positive_regulation denotes inactive
T9163 17333-17343 Gene_expression denotes expressing
T9162 17302-17311 Negative_regulation denotes deficient
T9161 17781-17785 Protein denotes IKK1
T9160 17680-17683 Protein denotes NIK
T9159 17660-17664 Protein denotes IKK1
T9158 17480-17484 Protein denotes IKK1
T9157 17596-17601 Protein denotes STAT1
T9156 17457-17461 Protein denotes IκBα
T9155 17437-17441 Protein denotes IKK2
T9154 17353-17357 Protein denotes IKK1
T9153 17297-17301 Protein denotes IKK1
T9152 17069-17073 Protein denotes IKK1
T9151 16915-16921 Protein denotes TOLLIP
T9150 16903-16909 Protein denotes IRAK-M
T9149 16895-16901 Protein denotes MyD88s
T7225 13781-13793 Localization denotes accumulation
T7224 13751-13762 Protein_catabolism denotes degradation
T7223 13715-13724 Localization denotes releasing
T7222 13647-13656 Positive_regulation denotes essential
T7221 13678-13689 Protein_catabolism denotes degradation
T7220 13610-13617 Binding denotes attract
T7219 13533-13539 Negative_regulation denotes remove
T7218 13431-13438 Positive_regulation denotes leading
T7217 13457-13468 Protein_catabolism denotes degradation
T7216 13206-13215 Regulation denotes regulated
T7215 13122-13131 Positive_regulation denotes activated
T7214 12832-12841 Binding denotes processed
T7213 12615-12639 Regulation denotes ubiquitination-dependent
T7212 12588-12596 Positive_regulation denotes activate
T7211 12556-12567 Binding denotes interaction
T7210 12509-12517 Binding denotes recruits
T7209 12434-12441 Positive_regulation denotes leading
T7208 12445-12460 Binding denotes oligomerisation
T7207 12361-12369 Binding denotes recruits
T7206 12033-12040 Positive_regulation denotes induces
T7205 12212-12219 Binding denotes recruit
T7204 12045-12056 Binding denotes recruitment
T7203 11893-11901 Positive_regulation denotes activate
T7202 11488-11505 Binding denotes ubiquitin-binding
T7201 11447-11454 Binding denotes recruit
T7200 11313-11327 Binding denotes ubiquitination
T7199 11219-11227 Positive_regulation denotes modified
T7198 11171-11182 Positive_regulation denotes stimulation
T7197 11071-11075 Binding denotes bind
T7196 10826-10837 Binding denotes recruitment
T7195 8484-8492 Positive_regulation denotes required
T7194 15890-15894 Protein denotes CD40
T7193 15850-15855 Protein denotes TRAF3
T7192 15803-15808 Protein denotes TRAF2
T7191 15780-15784 Protein denotes IL-6
T7190 15747-15751 Protein denotes CD40
T7189 15725-15730 Protein denotes TRAF6
T7188 15676-15680 Protein denotes CD40
T7187 15499-15504 Protein denotes TRAF3
T7186 15489-15494 Protein denotes TRAF2
T7185 15440-15445 Protein denotes TRAF6
T7184 15429-15434 Protein denotes TRAF5
T7183 15422-15427 Protein denotes TRAF3
T7182 15415-15420 Protein denotes TRAF2
T7181 15408-15413 Protein denotes TRAF1
T7180 15357-15361 Protein denotes RANK
T7179 15348-15352 Protein denotes CD40
T7178 15228-15232 Protein denotes RANK
T7177 15201-15223 Protein denotes lymphotoxin β receptor
T7176 15195-15199 Protein denotes CD40
T7175 13798-13802 Protein denotes IKK1
T7174 13777-13780 Protein denotes NIK
T7173 13725-13728 Protein denotes NIK
T7172 13672-13677 Protein denotes TRAF3
T7171 13634-13635 Protein denotes 2
T7170 13628-13633 Protein denotes cIAP1
T7169 13618-13623 Protein denotes TRAF2
T7168 13540-13545 Protein denotes TRAF3
T7167 13395-13396 Protein denotes 2
T7166 13389-13394 Protein denotes cIAP1
T7165 13378-13383 Protein denotes TRAF3
T7164 13371-13376 Protein denotes TRAF2
T7163 13330-13333 Protein denotes NIK
T7162 13426-13429 Protein denotes NIK
T7161 13185-13188 Protein denotes NIK
T7160 13179-13182 Protein denotes NIK
T7159 13156-13177 Protein denotes NF-κB inducing kinase
T7158 13107-13111 Protein denotes IKK1
T7157 12892-12896 Protein denotes RelB
T7156 12863-12866 Protein denotes p52
T7155 12824-12828 Protein denotes p100
T7154 12790-12794 Protein denotes RANK
T7153 12780-12784 Protein denotes CD40
T7152 12765-12778 Protein denotes BAFF receptor
T7151 12741-12763 Protein denotes lymphotoxin β receptor
T7150 12662-12665 Protein denotes TNF
T7149 12597-12601 Protein denotes TAK1
T7148 12533-12537 Protein denotes RIP1
T7147 12518-12523 Protein denotes TRAF6
T7146 12499-12503 Protein denotes TRIF
T7145 12487-12492 Protein denotes TRAF6
T7144 12427-12432 Protein denotes TRAF6
T7143 12347-12352 Protein denotes MyD88
T7142 12326-12330 Protein denotes TRIF
T7141 12281-12324 Protein denotes TIR domain-containing adaptor-inducing IFNβ
T7140 12270-12275 Protein denotes MyD88
T7139 12220-12268 Protein denotes myeloid differentiation primary response gene 88
T7138 12156-12160 Protein denotes TRAM
T7137 12125-12154 Protein denotes TRIF-related adaptor molecule
T7136 12116-12118 Protein denotes Ma
T7135 12060-12094 Protein denotes Toll/IL-1 receptor adaptor protein
T7134 11994-11998 Protein denotes TLR4
T7133 11906-11910 Protein denotes TAK1
T7132 11680-11683 Protein denotes TNF
T7131 11621-11625 Protein denotes NEMO
T7130 11529-11530 Protein denotes 2
T7129 11524-11528 Protein denotes TAB1
T7128 11515-11519 Protein denotes NEMO
T7127 11467-11471 Protein denotes TAK1
T7126 11405-11409 Protein denotes RIP1
T7125 11308-11312 Protein denotes RIP1
T7124 11282-11283 Protein denotes 2
T7123 11276-11281 Protein denotes cIAP1
T7122 11270-11271 Protein denotes 5
T7121 11264-11269 Protein denotes TRAF2
T7120 11203-11207 Protein denotes RIP1
T7119 11167-11170 Protein denotes TNF
T7118 11146-11151 Protein denotes cIAP2
T7117 11101-11141 Protein denotes cellular inhibitor of apoptosis (cIAP) 1
T7116 11050-11055 Protein denotes TRAF5
T7115 11006-11045 Protein denotes TNF receptor-associated factor (TRAF) 2
T7114 10935-10939 Protein denotes RIP1
T7113 10903-10933 Protein denotes receptor interacting protein 1
T7112 10881-10886 Protein denotes TRADD
T7111 10841-10879 Protein denotes TNF receptor-1-associated death domain
T7110 10795-10798 Protein denotes TNF
T7109 10782-10785 Protein denotes TNF
T7108 8474-8478 Protein denotes IKK1
T7107 8460-8464 Protein denotes NEMO
T7106 8451-8455 Protein denotes IKK2
T7105 8394-8398 Protein denotes IKKγ
T7104 8373-8377 Protein denotes NEMO
T7103 8346-8371 Protein denotes NF-κB essential modulator
T7102 8313-8317 Protein denotes IKKβ
T7101 8304-8308 Protein denotes IKKα
T7100 8284-8288 Protein denotes IKK2
T7099 8275-8279 Protein denotes IKK1
T7098 7830-7835 Protein denotes RANKL
T7097 7808-7811 Protein denotes TNF
T7096 7481-7484 Protein denotes p50
T7095 7473-7476 Protein denotes p52
T7094 7446-7450 Protein denotes p105
T7093 7437-7441 Protein denotes p100
T7092 7374-7379 Protein denotes Bcl-3
T7091 7365-7369 Protein denotes IκBξ
T7090 7326-7332 Protein denotes NF-κB2
T7089 7306-7310 Protein denotes p100
T7088 7297-7303 Protein denotes NF-κB1
T7087 7277-7281 Protein denotes p105
T7086 7271-7275 Protein denotes IκBε
T7085 7265-7269 Protein denotes IκBβ
T7084 7259-7263 Protein denotes IκBα
T7233 15752-15760 Positive_regulation denotes mediated
T7232 15734-15742 Positive_regulation denotes required
T7231 15785-15795 Gene_expression denotes production
T7230 15681-15689 Positive_regulation denotes mediated
T7229 15323-15330 Binding denotes binding
T7228 13764-13773 Positive_regulation denotes resulting
T7227 13700-13711 Positive_regulation denotes contributes
T7226 13803-13818 Phosphorylation denotes phosphorylation
T3400 6570-6577 Positive_regulation denotes induced
T3399 6147-6156 Positive_regulation denotes increased
T3398 6032-6040 Localization denotes released
T3397 5995-6003 Localization denotes secreted
T3396 4756-4764 Positive_regulation denotes Enhanced
T3395 4765-4775 Gene_expression denotes expression
T3394 4264-4273 Gene_expression denotes expressed
T3393 4207-4214 Binding denotes Binding
T3392 4146-4157 Positive_regulation denotes upregulated
T3391 3967-3976 Gene_expression denotes expressed
T3390 3650-3660 Positive_regulation denotes activation
T3389 6759-6769 Protein denotes tenascin C
T3388 6749-6757 Protein denotes biglycan
T3387 6736-6747 Protein denotes fibronectin
T3386 6565-6569 Protein denotes TLR4
T3385 6341-6367 Protein denotes myeloid-related protein 14
T3384 6311-6336 Protein denotes Myeloid-related protein 8
T3383 6248-6253 Protein denotes HMGB1
T3382 6183-6188 Protein denotes HMGB1
T3381 6138-6143 Protein denotes HMGB1
T3380 6099-6111 Protein denotes TLR4 ligands
T3379 5954-5973 Protein denotes chromatin component
T3378 5927-5932 Protein denotes HMGB1
T3377 5880-5925 Protein denotes High mobility group box chromosomal protein 1
T3376 5011-5033 Protein denotes lymphotoxin β receptor
T3375 4957-4961 Protein denotes BAFF
T3374 4836-4840 Protein denotes BAFF
T3373 4810-4834 Protein denotes B-cell activating factor
T3372 4576-4580 Protein denotes CD40
T3371 4302-4305 Protein denotes CD4
T3370 4235-4240 Protein denotes CD154
T3369 4222-4233 Protein denotes CD40 ligand
T3368 4197-4200 Protein denotes TNF
T3367 3919-3945 Protein denotes TNF receptor family member
T3366 3903-3907 Protein denotes CD40
T3365 3789-3793 Protein denotes RANK
T3364 3693-3697 Protein denotes RANK
T3363 3664-3691 Protein denotes receptor activator of NF-κB
T3362 3450-3453 Protein denotes TNF
T3361 3375-3378 Protein denotes TNF
T3360 3316-3319 Protein denotes TNF
T1404 2629-2638 Positive_regulation denotes mediating
T1403 2643-2650 Regulation denotes effects
T1402 1823-1831 Regulation denotes regulate
T1401 1836-1846 Gene_expression denotes expression
T1400 2966-2971 Protein denotes c-REL
T1399 2953-2960 Protein denotes TNFAIP3
T1398 2946-2951 Protein denotes TRAF1
T1397 2940-2944 Protein denotes CD40
T1396 2690-2695 Protein denotes RANKL
T1395 2654-2688 Protein denotes receptor activator of NF-κB ligand
T1394 2035-2038 Protein denotes TNF
T1393 1884-1887 Protein denotes TNF
T1392 1758-1763 Protein denotes c-Rel
T1391 1752-1756 Protein denotes RelB
T1390 1746-1750 Protein denotes RelA
T1389 1739-1742 Protein denotes p65
T1388 1731-1737 Protein denotes NF-κB1
T1387 1723-1727 Protein denotes p105
T1386 1715-1721 Protein denotes NF-κB2
T1385 1932-1963 Protein denotes inducible nitric oxide synthase
T1384 1901-1918 Protein denotes cyclo-oxygenase-2
T1383 1895-1899 Protein denotes IL-6
T1382 1707-1711 Protein denotes p100
T18570 31680-31683 Protein denotes TNF
T18569 31651-31658 Protein denotes miR-155
T18568 31450-31457 Protein denotes miR-155
T18567 31364-31372 Protein denotes miR-146a
T18566 31263-31268 Protein denotes IL-17
T18565 31254-31257 Protein denotes CD4
R9179 T13678 T13709 themeOf ABIN-3,interacting
R9182 T13682 T13709 themeOf A20,interacting
R9185 T13685 T13712 causeOf A20,dependent
R9187 T13686 T13712 causeOf ABIN-1,dependent
R9188 T13686 T13712 causeOf ABIN-1,dependent
R9189 T13687 T13711 themeOf ABIN-3,expression
R9195 T13692 T13717 themeOf truncated and inactive form,ubiquitin-binding
R9196 T13693 T13719 themeOf A20,inhibits
R9197 T13694 T13719 causeOf ABIN-1,inhibits
R9198 T13696 T13720 themeOf ABIN-1,deficient
R9199 T13703 T13721 themeOf ABIN-3,expression
R9203 T13711 T13712 themeOf expression,dependent
R2685 T3367 T3392 themeOf TNF receptor family member,upregulated
R2686 T3367 T3391 themeOf TNF receptor family member,expressed
R2687 T3369 T3393 themeOf CD40 ligand,Binding
R2688 T3370 T3393 themeOf CD154,Binding
R2689 T3370 T3394 themeOf CD154,expressed
R2691 T3373 T3395 themeOf B-cell activating factor,expression
R2692 T3374 T3395 themeOf BAFF,expression
R2695 T3379 T3397 themeOf chromatin component,secreted
R2696 T3379 T3398 themeOf chromatin component,released
R2697 T3381 T3399 themeOf HMGB1,increased
R2700 T3386 T3400 themeOf TLR4,induced
R2705 T3395 T3396 themeOf expression,Enhanced
R2706 T3395 T3396 themeOf expression,Enhanced
R4973 T7106 T7195 themeOf IKK2,required
R4974 T7107 T7195 themeOf NEMO,required
R4975 T7108 T7195 causeOf IKK1,required
R4976 T7108 T7195 causeOf IKK1,required
R4978 T7111 T7196 themeOf TNF receptor-1-associated death domain,recruitment
R4979 T7112 T7196 themeOf TRADD,recruitment
R4980 T7112 T7196 themeOf TRADD,recruitment
R4981 T7113 T7196 themeOf receptor interacting protein 1,recruitment
R4982 T7113 T7197 themeOf receptor interacting protein 1,bind
R4983 T7113 T7196 themeOf receptor interacting protein 1,recruitment
R4984 T7113 T7197 themeOf receptor interacting protein 1,bind
R4985 T7113 T7197 themeOf receptor interacting protein 1,bind
R4987 T7114 T7196 themeOf RIP1,recruitment
R4988 T7114 T7197 themeOf RIP1,bind
R4989 T7114 T7197 themeOf RIP1,bind
R4990 T7114 T7197 themeOf RIP1,bind
R4991 T7115 T7197 themeOf TNF receptor-associated factor (TRAF) 2,bind
R4992 T7115 T7197 themeOf TNF receptor-associated factor (TRAF) 2,bind
R4993 T7116 T7197 themeOf TRAF5,bind
R4994 T7116 T7197 themeOf TRAF5,bind
R4995 T7116 T7197 themeOf TRAF5,bind
R4996 T7116 T7197 themeOf TRAF5,bind
R4997 T7117 T7197 themeOf cellular inhibitor of apoptosis (cIAP) 1,bind
R4998 T7117 T7197 themeOf cellular inhibitor of apoptosis (cIAP) 1,bind
R4999 T7117 T7197 themeOf cellular inhibitor of apoptosis (cIAP) 1,bind
R5000 T7117 T7197 themeOf cellular inhibitor of apoptosis (cIAP) 1,bind
R5001 T7118 T7197 themeOf cIAP2,bind
R5002 T7118 T7197 themeOf cIAP2,bind
R5003 T7118 T7197 themeOf cIAP2,bind
R5004 T7118 T7197 themeOf cIAP2,bind
R5005 T7119 T7198 themeOf TNF,stimulation
R5006 T7120 T7199 themeOf RIP1,modified
R5007 T7121 T7200 themeOf TRAF2,ubiquitination
R5009 T7123 T7200 themeOf cIAP1,ubiquitination
R5010 T7125 T7200 themeOf RIP1,ubiquitination
R5011 T7125 T7200 themeOf RIP1,ubiquitination
R5012 T7127 T7201 themeOf TAK1,recruit
R5013 T7127 T7201 themeOf TAK1,recruit
R5014 T7127 T7201 themeOf TAK1,recruit
R5015 T7128 T7201 themeOf NEMO,recruit
R5016 T7128 T7202 themeOf NEMO,ubiquitin-binding
R5017 T7128 T7202 themeOf NEMO,ubiquitin-binding
R5018 T7129 T7202 themeOf TAB1,ubiquitin-binding
R5019 T7129 T7201 themeOf TAB1,recruit
R5020 T7129 T7202 themeOf TAB1,ubiquitin-binding
R5021 T7130 T7201 themeOf 2,recruit
R5022 T7130 T7202 themeOf 2,ubiquitin-binding
R5023 T7130 T7202 themeOf 2,ubiquitin-binding
R5024 T7133 T7203 themeOf TAK1,activate
R5025 T7135 T7204 themeOf Toll/IL-1 receptor adaptor protein,recruitment
R5026 T7135 T7205 themeOf Toll/IL-1 receptor adaptor protein,recruit
R5027 T7135 T7204 themeOf Toll/IL-1 receptor adaptor protein,recruitment
R5028 T7135 T7205 themeOf Toll/IL-1 receptor adaptor protein,recruit
R5029 T7135 T7205 themeOf Toll/IL-1 receptor adaptor protein,recruit
R5030 T7135 T7205 themeOf Toll/IL-1 receptor adaptor protein,recruit
R5032 T7137 T7204 themeOf TRIF-related adaptor molecule,recruitment
R5033 T7137 T7204 themeOf TRIF-related adaptor molecule,recruitment
R5034 T7137 T7205 themeOf TRIF-related adaptor molecule,recruit
R5035 T7137 T7205 themeOf TRIF-related adaptor molecule,recruit
R5036 T7138 T7204 themeOf TRAM,recruitment
R5037 T7138 T7204 themeOf TRAM,recruitment
R5040 T7138 T7205 themeOf TRAM,recruit
R5041 T7138 T7205 themeOf TRAM,recruit
R5042 T7139 T7205 themeOf myeloid differentiation primary response gene 88,recruit
R5043 T7140 T7205 themeOf MyD88,recruit
R5044 T7141 T7205 themeOf TIR domain-containing adaptor-inducing IFNβ,recruit
R5045 T7141 T7205 themeOf TIR domain-containing adaptor-inducing IFNβ,recruit
R5046 T7141 T7205 themeOf TIR domain-containing adaptor-inducing IFNβ,recruit
R5047 T7142 T7205 themeOf TRIF,recruit
R5048 T7142 T7205 themeOf TRIF,recruit
R5049 T7142 T7205 themeOf TRIF,recruit
R5053 T7143 T7207 themeOf MyD88,recruits
R5054 T7144 T7207 themeOf TRAF6,recruits
R5055 T7145 T7208 themeOf TRAF6,oligomerisation
R5056 T7146 T7210 themeOf TRIF,recruits
R5057 T7146 T7211 themeOf TRIF,interaction
R5058 T7146 T7210 themeOf TRIF,recruits
R5059 T7146 T7211 themeOf TRIF,interaction
R5060 T7147 T7210 themeOf TRAF6,recruits
R5061 T7147 T7211 themeOf TRAF6,interaction
R5062 T7147 T7211 themeOf TRAF6,interaction
R5063 T7148 T7210 themeOf RIP1,recruits
R5064 T7148 T7211 themeOf RIP1,interaction
R5065 T7148 T7211 themeOf RIP1,interaction
R5066 T7149 T7212 themeOf TAK1,activate
R5068 T7155 T7214 themeOf p100,processed
R5069 T7156 T7214 themeOf p52,processed
R5070 T7158 T7215 themeOf IKK1,activated
R5071 T7159 T7215 causeOf NF-κB inducing kinase,activated
R5073 T7161 T7216 themeOf NIK,regulated
R5074 T7163 T7217 themeOf NIK,degradation
R5077 T7167 T7217 themeOf 2,degradation
R5078 T7168 T7219 themeOf TRAF3,remove
R5079 T7169 T7220 themeOf TRAF2,attract
R5080 T7169 T7222 causeOf TRAF2,essential
R5081 T7169 T7220 themeOf TRAF2,attract
R5082 T7170 T7220 themeOf cIAP1,attract
R5083 T7170 T7220 themeOf cIAP1,attract
R5084 T7170 T7222 causeOf cIAP1,essential
R5085 T7171 T7220 themeOf 2,attract
R5086 T7171 T7220 themeOf 2,attract
R5087 T7171 T7222 causeOf 2,essential
R5088 T7208 T7209 themeOf oligomerisation,leading
R5089 T7172 T7221 themeOf TRAF3,degradation
R5090 T7173 T7223 themeOf NIK,releasing
R5091 T7173 T7224 themeOf NIK,degradation
R5092 T7174 T7225 themeOf NIK,accumulation
R5093 T7175 T7226 themeOf IKK1,phosphorylation
R5094 T7212 T7213 themeOf activate,ubiquitination-dependent
R5095 T7179 T7229 themeOf CD40,binding
R5096 T7182 T7229 themeOf TRAF2,binding
R5097 T7217 T7218 themeOf degradation,leading
R5098 T7188 T7230 themeOf CD40,mediated
R5099 T7189 T7232 causeOf TRAF6,required
R5100 T7190 T7233 causeOf CD40,mediated
R5101 T7191 T7231 themeOf IL-6,production
R5102 T7217 T7218 themeOf degradation,leading
R5103 T7221 T7222 themeOf degradation,essential
R5104 T7198 T7199 themeOf stimulation,modified
R5105 T7221 T7222 themeOf degradation,essential
R5106 T7221 T7222 themeOf degradation,essential
R5107 T7204 T7206 themeOf recruitment,induces
R5108 T7204 T7206 themeOf recruitment,induces
R5109 T7204 T7206 themeOf recruitment,induces
R5110 T7223 T7227 themeOf releasing,contributes
R5111 T7225 T7228 themeOf accumulation,resulting
R5112 T7226 T7228 themeOf phosphorylation,resulting
R5113 T7231 T7232 themeOf production,required
R5114 T7231 T7233 themeOf production,mediated
R6255 T9153 T9162 themeOf IKK1,deficient
R6256 T9154 T9163 themeOf IKK1,expressing
R6257 T9154 T9164 themeOf IKK1,inactive
R6258 T9155 T9165 themeOf IKK2,activation
R6259 T9156 T9166 themeOf IκBα,degradation
R6260 T9157 T9169 themeOf STAT1,phosphorylating
R6261 T9159 T9170 causeOf IKK1,phosphorylates
R6262 T9160 T9170 themeOf NIK,phosphorylates
R6263 T9165 T9167 themeOf activation,result
R6264 T9165 T9168 themeOf activation,enhanced
R6265 T9166 T9167 themeOf degradation,result
R8100 T11852 T11896 themeOf A20,association
R8102 T11884 T11915 themeOf A20,association
R8103 T11884 T11916 themeOf A20,mutations
R8104 T11853 T11898 themeOf A20-binding inhibitor of NF-κB (ABIN) 1,ubiquitin-binding
R8105 T11853 T11899 causeOf A20-binding inhibitor of NF-κB (ABIN) 1,requires
R8106 T11854 T11898 themeOf Tax1-binding protein 1,ubiquitin-binding
R8107 T11855 T11900 themeOf A20,inhibitor
R8108 T11892 T11917 themeOf A20,affect
R8109 T11894 T11918 themeOf A20,transcription
R8110 T11857 T11901 themeOf A20,deficient
R8111 T11896 T11897 themeOf association,targets
R8112 T11858 T11902 themeOf A20,deficient
R8113 T11898 T11899 themeOf ubiquitin-binding,requires
R8114 T11860 T11903 themeOf A20,lacking
R8115 T11863 T11904 themeOf A20,lacking
R8116 T11906 T11907 themeOf expression,regulated
R8117 T11864 T11905 themeOf A20,expression
R8118 T11865 T11906 themeOf A20,expression
R8119 T11867 T11908 themeOf A20,expressing
R8120 T11915 T11916 themeOf association,mutations
R8121 T11868 T11909 themeOf A20,expression
R8122 T11918 T11919 themeOf transcription,repressed
R8123 T11869 T11910 themeOf TNF,decreased
R8124 T11870 T11910 themeOf IL-1β,decreased
R8125 T11871 T11910 themeOf IL-6,decreased
R8126 T11872 T11910 themeOf RANKL,decreased
R8127 T11873 T11910 themeOf monocyte chemo-attractant protein 1,decreased
R8128 T11877 T11911 themeOf TNF,decreased
R8129 T11878 T11911 themeOf IL-1β,decreased
R8130 T11879 T11912 themeOf A20,transduced
R8132 T11880 T11913 themeOf A20,overexpression
R8137 T11882 T11914 themeOf A20,lack
R9177 T13675 T13706 themeOf A20,binding
R9178 T13677 T13709 themeOf ABIN-2,interacting
R9180 T13682 T13708 themeOf A20,expressed
R9181 T13682 T13709 themeOf A20,interacting
R9183 T13684 T13710 themeOf A20,target
R9184 T13685 T13712 causeOf A20,dependent
R9186 T13686 T13711 themeOf ABIN-1,expression
R9190 T13689 T13713 themeOf ABIN-1,deficient
R9191 T13690 T13714 themeOf ABIN-2,deficient
R9192 T13691 T13715 themeOf ABIN-3,expressed
R9193 T13691 T13717 themeOf ABIN-3,ubiquitin-binding
R9194 T13692 T13716 themeOf truncated and inactive form,express
R9201 T13706 T13707 themeOf binding,inhibitors
R9202 T13711 T13712 themeOf expression,dependent
R10680 T16088 T16101 themeOf IL-1R,inhibitor
R10681 T16088 T16102 themeOf IL-1R,interaction
R10682 T16088 T16102 themeOf IL-1R,interaction
R10683 T16088 T16102 themeOf IL-1R,interaction
R10684 T16089 T16101 themeOf MyD88,inhibitor
R10685 T16090 T16101 themeOf IRAK1,inhibitor
R10686 T16091 T16101 themeOf TRAF6,inhibitor
R10687 T16094 T16103 themeOf SIGIRR,expression
R10688 T16094 T16104 themeOf SIGIRR,expressed
R10689 T16095 T16105 themeOf SIGIRR,overexpression
R10690 T16097 T16106 themeOf SIGIRR,deficient
R10691 T16098 T16107 themeOf SIGIRR,expression
R10692 T16099 T16108 themeOf SIGIRR,compromised
R10693 T16100 T16109 themeOf SIGIRR,expression
R10694 T16102 T16101 themeOf interaction,inhibitor
R10695 T16102 T16101 themeOf interaction,inhibitor
R10696 T16102 T16101 themeOf interaction,inhibitor
R11292 T17045 T17062 themeOf TRAF1,Expression
R11293 T17046 T17063 causeOf TNF,inducible
R11294 T17047 T17064 themeOf TRAF1,overexpression
R11295 T17050 T17065 themeOf TRAF1,deficient
R11296 T17053 T17066 themeOf TRAF1,deficient
R11297 T17056 T17067 themeOf TRAF1,binding
R11298 T17057 T17068 themeOf TRAF1,recruit
R11299 T17058 T17068 themeOf A20,recruit
R11300 T17058 T17069 themeOf A20,interact
R11301 T17061 T17070 themeOf TRAF1,association
R11302 T17062 T17063 themeOf Expression,inducible
R12374 T18556 T18581 themeOf miR-146a,NF-κB-dependent
R12375 T18563 T18582 themeOf miR-155,expressed
R12376 T18564 T18583 themeOf miR-146a,overexpressed
R12377 T18565 T18584 themeOf CD4,producing
R12378 T18566 T18584 themeOf IL-17,producing
R12379 T18568 T18585 themeOf miR-155,overexpression
R12380 T18569 T18587 causeOf miR-155,promote
R12381 T18570 T18586 themeOf TNF,production
R12382 T18573 T18589 themeOf miR-124a,decreased
R12383 T18574 T18588 themeOf monocyte chemoattractant protein 1,regulator
R12384 T18576 T18590 themeOf matrix metalloproteinase-1,secretion
R12385 T18577 T18590 themeOf IL-6,secretion
R12386 T18578 T18593 themeOf miR-16,expression
R12387 T18579 T18593 themeOf miR-132,expression
R12388 T18580 T18593 themeOf miR-223,expression
R12389 T18586 T18587 themeOf production,promote
R12390 T18590 T18591 themeOf secretion,leading
R12391 T18590 T18592 themeOf secretion,increased
R12392 T18590 T18591 themeOf secretion,leading
R12393 T18590 T18592 themeOf secretion,increased
R13713 T20677 T20716 themeOf RIP1,polyubiquitination
R13714 T20678 T20716 themeOf IRAK1,polyubiquitination
R13715 T20680 T20717 themeOf IKK2,recruitment
R13716 T20681 T20717 themeOf TAK1,recruitment
R13717 T20682 T20719 causeOf TAK1,activates
R13718 T20683 T20719 themeOf IKK2,activates
R13719 T20683 T20720 themeOf IKK2,phosphorylates
R13720 T20684 T20720 themeOf IκBα,phosphorylates
R13721 T20685 T20721 themeOf p65,heterodimer
R13722 T20686 T20721 themeOf p50,heterodimer
R13723 T20690 T20722 themeOf RIP1,recruited
R13724 T20690 T20722 themeOf RIP1,recruited
R13725 T20691 T20722 themeOf TRAF6,recruited
R13726 T20692 T20722 themeOf ABIN-1,recruited
R13727 T20692 T20722 themeOf ABIN-1,recruited
R13728 T20693 T20722 themeOf p62,recruited
R13729 T20694 T20723 themeOf IRAK1,expression
R13730 T20695 T20723 themeOf TRAF6,expression
R13731 T20696 T20725 themeOf SIGIRR,compete
R13732 T20697 T20725 themeOf TLR4,compete
R13733 T20698 T20726 themeOf IRAK1,binding
R13734 T20699 T20726 themeOf TRAF6,binding
R13735 T20717 T20718 themeOf recruitment,activation
R13736 T20723 T20724 themeOf expression,inhibiting
R13737 T20723 T20724 themeOf expression,inhibiting
R14470 T22158 T22190 themeOf NF-κB inducing kinase,expression
R14471 T22159 T22190 themeOf NIK,expression
R14472 T22160 T22192 themeOf NIK,polyubiquitination
R14473 T22160 T22193 themeOf NIK,degradation
R14474 T22161 T22194 themeOf NIK,low
R14475 T22167 T22196 themeOf TRAF3,recruited
R14476 T22168 T22199 causeOf TRAF2,directs
R14477 T22168 T22199 causeOf TRAF2,directs
R14478 T22168 T22199 causeOf TRAF2,directs
R14479 T22168 T22199 causeOf TRAF2,directs
R14480 T22169 T22197 themeOf cIAP1,nondegradative
R14481 T22169 T22198 themeOf cIAP1,polyubiquitination
R14482 T22170 T22197 themeOf 2,nondegradative
R14483 T22170 T22198 themeOf 2,polyubiquitination
R14484 T22171 T22200 themeOf cIAP1,polyubiquitination
R14485 T22173 T22200 themeOf TRAF3,polyubiquitination
R14486 T22175 T22201 themeOf TRAF3,degraded
R14487 T22176 T22202 themeOf NIK,stabilised
R14488 T22177 T22203 themeOf NIK,resulting
R14489 T22177 T22204 themeOf NIK,increased
R14490 T22178 T22205 causeOf NIK,activates
R14491 T22179 T22205 themeOf IKK1,activates
R14492 T22179 T22206 themeOf IKK1,mediates
R14493 T22180 T22207 themeOf p100,phosphorylation
R14494 T22181 T22208 themeOf p100,degradation
R14495 T22182 T22208 themeOf p52,degradation
R14496 T22183 T22209 themeOf RelB,heterodimer
R14497 T22185 T22210 themeOf TRAF1,regulator
R14498 T22186 T22211 themeOf RANK,inhibitor
R14499 T22187 T22211 themeOf receptor activator of NF-κB,inhibitor
R14500 T22188 T22211 themeOf TNF,inhibitor
R14501 T22189 T22211 themeOf tumour necrosis factor,inhibitor
R14502 T22190 T22191 themeOf expression,dependent
R14503 T22190 T22191 themeOf expression,dependent
R14504 T22192 T22195 themeOf polyubiquitination,facilitates
R14505 T22193 T22195 themeOf degradation,facilitates
R14506 T22197 T22198 themeOf nondegradative,polyubiquitination
R14507 T22197 T22198 themeOf nondegradative,polyubiquitination
R14508 T22198 T22199 themeOf polyubiquitination,directs
R14509 T22198 T22199 themeOf polyubiquitination,directs
R14510 T22198 T22199 themeOf polyubiquitination,directs
R14511 T22198 T22199 themeOf polyubiquitination,directs
R14512 T22204 T22203 themeOf increased,resulting
R14513 T22207 T22206 themeOf phosphorylation,mediates
R1113 T1382 T1402 causeOf p100,regulate
R1114 T1382 T1402 causeOf p100,regulate
R1115 T1382 T1402 causeOf p100,regulate
R1116 T1382 T1402 causeOf p100,regulate
R1117 T1383 T1401 themeOf IL-6,expression
R1118 T1384 T1401 themeOf cyclo-oxygenase-2,expression
R1119 T1385 T1401 themeOf inducible nitric oxide synthase,expression
R1120 T1393 T1401 themeOf TNF,expression
R1121 T1395 T1403 themeOf receptor activator of NF-κB ligand,effects
R1122 T1401 T1402 themeOf expression,regulate
R1123 T1401 T1402 themeOf expression,regulate
R1124 T1401 T1402 themeOf expression,regulate
R1125 T1401 T1402 themeOf expression,regulate
R1126 T1403 T1404 themeOf effects,mediating
R2683 T3363 T3390 themeOf receptor activator of NF-κB,activation
R2684 T3366 T3391 themeOf CD40,expressed
R9204 T13711 T13712 themeOf expression,dependent
R9205 T13711 T13712 themeOf expression,dependent
R9206 T13717 T13718 themeOf ubiquitin-binding,lacking
R9207 T13721 T13722 themeOf expression,depend
R9200 T13704 T13721 themeOf A20,expression
R9208 T13721 T13722 themeOf expression,depend
R10051 T15088 T15106 themeOf A20,expressed
R10052 T15092 T15107 themeOf CYLD,deficiency
R10053 T15094 T15108 themeOf CYLD,expression
R10054 T15096 T15110 themeOf TRAF6,recruited
R10055 T15096 T15111 themeOf TRAF6,ubiquitinated
R10056 T15097 T15112 themeOf ubiquitin,binding
R10057 T15098 T15110 themeOf p62,recruited
R10058 T15098 T15112 themeOf p62,binding
R10059 T15101 T15113 themeOf TRAF6,deubiquitination
R10060 T15102 T15114 themeOf p62,expressing
R10061 T15108 T15109 themeOf expression,upregulated
R10677 T16085 T16102 themeOf Single-immunoglobulin IL-1 receptor-related,interaction
R10678 T16086 T16102 themeOf SIGIRR,interaction
R10679 T16087 T16102 themeOf TIR-8,interaction

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T22106 15106-15136 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TNF receptor-associated factor
T22105 15138-15141 http://www.uniprot.org/uniprot/P01375 denotes TNF
T22104 15106-15109 http://www.uniprot.org/uniprot/P01375 denotes TNF
T22103 14956-14959 http://www.uniprot.org/uniprot/P01375 denotes TNF
T22102 14799-14803 http://www.uniprot.org/uniprot/Q01201 denotes RelB
T22101 14763-14766 http://www.uniprot.org/uniprot/Q00653 denotes p52
T22100 14755-14759 http://www.uniprot.org/uniprot/Q00653 denotes p100
T22099 14644-14648 http://www.uniprot.org/uniprot/Q00653 denotes p100
T22098 15033-15043 http://www.uniprot.org/uniprot/Q60680-2 denotes IκB kinase
T22097 14617-14621 http://www.uniprot.org/uniprot/Q60680-2 denotes IKK1
T22096 15033-15043 http://www.uniprot.org/uniprot/O15111 denotes IκB kinase
T22095 14617-14621 http://www.uniprot.org/uniprot/O15111 denotes IKK1
T22094 14401-14406 http://www.uniprot.org/uniprot/Q13490 denotes cIAP1
T22093 14348-14353 http://www.uniprot.org/uniprot/Q13490 denotes cIAP1
T22092 14102-14107 http://www.uniprot.org/uniprot/Q13490 denotes cIAP1
T22091 15106-15136 http://www.uniprot.org/uniprot/Q13114 denotes TNF receptor-associated factor
T22090 14839-14844 http://www.uniprot.org/uniprot/Q13114 denotes TRAF3
T22089 14491-14496 http://www.uniprot.org/uniprot/Q13114 denotes TRAF3
T22088 14454-14459 http://www.uniprot.org/uniprot/Q13114 denotes TRAF3
T22087 14244-14249 http://www.uniprot.org/uniprot/Q13114 denotes TRAF3
T22086 14092-14097 http://www.uniprot.org/uniprot/Q13114 denotes TRAF3
T22085 15106-15136 http://www.uniprot.org/uniprot/Q12933 denotes TNF receptor-associated factor
T22084 14286-14291 http://www.uniprot.org/uniprot/Q12933 denotes TRAF2
T22083 14085-14090 http://www.uniprot.org/uniprot/Q12933 denotes TRAF2
T22082 14579-14582 http://www.uniprot.org/uniprot/Q99558 denotes NIK
T22081 14555-14558 http://www.uniprot.org/uniprot/Q99558 denotes NIK
T22080 14513-14516 http://www.uniprot.org/uniprot/Q99558 denotes NIK
T22079 14473-14476 http://www.uniprot.org/uniprot/Q99558 denotes NIK
T22078 14207-14210 http://www.uniprot.org/uniprot/Q99558 denotes NIK
T22077 14194-14197 http://www.uniprot.org/uniprot/Q99558 denotes NIK
T22076 14028-14031 http://www.uniprot.org/uniprot/Q99558 denotes NIK
T22075 13982-13985 http://www.uniprot.org/uniprot/Q99558 denotes NIK
T22074 13880-13884 http://www.uniprot.org/uniprot/P25942 denotes CD40
T20589 10299-10309 http://www.uniprot.org/uniprot/Q60680-2 denotes IκB kinase
T20588 10299-10309 http://www.uniprot.org/uniprot/O15111 denotes IκB kinase
T20587 9760-9766 http://www.uniprot.org/uniprot/Q15025 denotes ABIN-1
T20586 10200-10203 http://www.uniprot.org/uniprot/P21580 denotes A20
T20585 9534-9537 http://www.uniprot.org/uniprot/P21580 denotes A20
T20584 9329-9332 http://www.uniprot.org/uniprot/P19838 denotes p50
T20583 9321-9324 http://www.uniprot.org/uniprot/P21579 denotes p65
T20582 9321-9324 http://www.uniprot.org/uniprot/Q04206 denotes p65
T20581 9195-9199 http://www.uniprot.org/uniprot/P25963 denotes IκBα
T20580 9160-9164 http://www.uniprot.org/uniprot/O14920 denotes IKK2
T20579 9106-9110 http://www.uniprot.org/uniprot/O14920 denotes IKK2
T20578 10424-10428 http://www.uniprot.org/uniprot/Q9Y6K9 denotes NEMO
T20577 9023-9027 http://www.uniprot.org/uniprot/Q9Y6K9 denotes NEMO
T20576 8919-8924 http://www.uniprot.org/uniprot/Q13490 denotes cIAP1
T20575 10031-10036 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TRAF6
T20574 9871-9876 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TRAF6
T20573 9667-9672 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TRAF6
T20572 8912-8917 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TRAF6
T20571 8905-8910 http://www.uniprot.org/uniprot/Q12933 denotes TRAF2
T20570 10512-10516 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T20569 9658-9662 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T20568 8990-8994 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T20567 8861-8865 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T20566 8794-8797 http://www.uniprot.org/uniprot/P01732 denotes MAL
T20565 10367-10372 http://www.uniprot.org/uniprot/Q99836 denotes MyD88
T20564 8787-8792 http://www.uniprot.org/uniprot/Q99836 denotes MyD88
T20563 10696-10699 http://www.uniprot.org/uniprot/P01375 denotes TNF
T20562 10639-10642 http://www.uniprot.org/uniprot/P01375 denotes TNF
T20561 8731-8734 http://www.uniprot.org/uniprot/P01375 denotes TNF
T20560 10001-10005 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T20559 8672-8676 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T20558 8656-8660 http://www.uniprot.org/uniprot/P25942 denotes CD40
T18508 32575-32579 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T18507 31263-31268 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T18506 31254-31257 http://www.uniprot.org/uniprot/P01730 denotes CD4
T18505 31015-31019 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T18504 30853-30858 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TRAF6
T18503 31680-31683 http://www.uniprot.org/uniprot/P01375 denotes TNF
T18502 30736-30739 http://www.uniprot.org/uniprot/P01375 denotes TNF
T18501 30729-30734 http://www.uniprot.org/uniprot/P01584 denotes IL-1β
T17010 29728-29731 http://www.uniprot.org/uniprot/P21580 denotes A20
T17009 29426-29431 http://www.uniprot.org/uniprot/Q12933 denotes TRAF2
T17008 29299-29303 http://www.uniprot.org/uniprot/P25942 denotes CD40
T17007 29170-29173 http://www.uniprot.org/uniprot/P01375 denotes TNF
T17006 29092-29095 http://www.uniprot.org/uniprot/P01375 denotes TNF
T17005 29051-29054 http://www.uniprot.org/uniprot/P01375 denotes TNF
T17004 28943-28946 http://www.uniprot.org/uniprot/P01375 denotes TNF
T17003 28655-28658 http://www.uniprot.org/uniprot/P01375 denotes TNF
T16058 27666-27671 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TRAF6
T16057 27650-27655 http://www.uniprot.org/uniprot/Q99836 denotes MyD88
T15028 26824-26838 http://www.uniprot.org/uniprot/Q13501 denotes sequestosome 1
T15027 25985-25988 http://www.uniprot.org/uniprot/P21580 denotes A20
T15026 25933-25936 http://www.uniprot.org/uniprot/P21580 denotes A20
T15025 25884-25887 http://www.uniprot.org/uniprot/P21580 denotes A20
T15024 25834-25838 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T15023 26896-26901 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TRAF6
T15022 26757-26762 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TRAF6
T15021 25820-25825 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TRAF6
T15020 25813-25818 http://www.uniprot.org/uniprot/Q12933 denotes TRAF2
T15019 25807-25811 http://www.uniprot.org/uniprot/Q9Y6K9 denotes NEMO
T13627 24076-24079 http://www.uniprot.org/uniprot/P01375 denotes TNF
T13626 23962-23965 http://www.uniprot.org/uniprot/P01375 denotes TNF
T13625 23883-23886 http://www.uniprot.org/uniprot/P01375 denotes TNF
T13624 23080-23083 http://www.uniprot.org/uniprot/P01375 denotes TNF
T13623 23516-23522 http://www.uniprot.org/uniprot/Q8NFZ5 denotes ABIN-2
T13622 22906-22912 http://www.uniprot.org/uniprot/Q8NFZ5 denotes ABIN-2
T13621 24679-24685 http://www.uniprot.org/uniprot/Q15025 denotes ABIN-1
T13620 24217-24223 http://www.uniprot.org/uniprot/Q15025 denotes ABIN-1
T13619 24136-24142 http://www.uniprot.org/uniprot/Q15025 denotes ABIN-1
T13618 24048-24054 http://www.uniprot.org/uniprot/Q15025 denotes ABIN-1
T13617 23915-23921 http://www.uniprot.org/uniprot/Q15025 denotes ABIN-1
T13616 23853-23859 http://www.uniprot.org/uniprot/Q15025 denotes ABIN-1
T13615 23495-23501 http://www.uniprot.org/uniprot/Q15025 denotes ABIN-1
T13614 23297-23303 http://www.uniprot.org/uniprot/Q15025 denotes ABIN-1
T13613 22898-22904 http://www.uniprot.org/uniprot/Q15025 denotes ABIN-1
T13612 24537-24540 http://www.uniprot.org/uniprot/P21580 denotes A20
T13611 24239-24242 http://www.uniprot.org/uniprot/P21580 denotes A20
T13610 23848-23851 http://www.uniprot.org/uniprot/P21580 denotes A20
T13609 23383-23386 http://www.uniprot.org/uniprot/P21580 denotes A20
T13608 23292-23295 http://www.uniprot.org/uniprot/P21580 denotes A20
T13607 23236-23239 http://www.uniprot.org/uniprot/P21580 denotes A20
T13606 23009-23012 http://www.uniprot.org/uniprot/P21580 denotes A20
T13605 22866-22869 http://www.uniprot.org/uniprot/P21580 denotes A20
T11743 20680-20685 http://www.uniprot.org/uniprot/Q16552 denotes IL-17
T11742 20618-20622 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T11741 21004-21009 http://www.uniprot.org/uniprot/P01584 denotes IL-1β
T11740 20869-20874 http://www.uniprot.org/uniprot/P01584 denotes IL-1β
T11739 20611-20616 http://www.uniprot.org/uniprot/P01584 denotes IL-1β
T11738 18887-18904 http://www.uniprot.org/uniprot/Q9UFW8 denotes binding protein 1
T11737 18887-18904 http://www.uniprot.org/uniprot/Q13541 denotes binding protein 1
T11736 18887-18904 http://www.uniprot.org/uniprot/Q86VP1 denotes binding protein 1
T11735 18887-18904 http://www.uniprot.org/uniprot/O00560 denotes binding protein 1
T11734 18870-18877 http://www.uniprot.org/uniprot/Q15025 denotes ABIN) 1
T11733 18628-18633 http://www.uniprot.org/uniprot/Q13490 denotes cIAP1
T11732 18618-18623 http://www.uniprot.org/uniprot/Q12933 denotes TRAF2
T11731 18404-18409 http://www.uniprot.org/uniprot/Q9UDY8 denotes MALT1
T11730 18611-18616 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TRAF6
T11729 18394-18399 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TRAF6
T11728 18382-18386 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T11727 22176-22179 http://www.uniprot.org/uniprot/P01375 denotes TNF
T11726 22151-22154 http://www.uniprot.org/uniprot/P01375 denotes TNF
T11725 20996-20999 http://www.uniprot.org/uniprot/P01375 denotes TNF
T11724 20861-20864 http://www.uniprot.org/uniprot/P01375 denotes TNF
T11723 20606-20609 http://www.uniprot.org/uniprot/P01375 denotes TNF
T11722 19643-19646 http://www.uniprot.org/uniprot/P01375 denotes TNF
T11721 19360-19363 http://www.uniprot.org/uniprot/P01375 denotes TNF
T11720 18132-18135 http://www.uniprot.org/uniprot/P01375 denotes TNF
T11719 17972-17979 http://www.uniprot.org/uniprot/P21580 denotes TNFAIP3
T11718 22555-22558 http://www.uniprot.org/uniprot/P21580 denotes A20
T11717 22507-22510 http://www.uniprot.org/uniprot/P21580 denotes A20
T11716 22327-22330 http://www.uniprot.org/uniprot/P21580 denotes A20
T11715 22246-22249 http://www.uniprot.org/uniprot/P21580 denotes A20
T11714 22116-22119 http://www.uniprot.org/uniprot/P21580 denotes A20
T11713 22029-22032 http://www.uniprot.org/uniprot/P21580 denotes A20
T11712 21982-21985 http://www.uniprot.org/uniprot/P21580 denotes A20
T11711 21828-21831 http://www.uniprot.org/uniprot/P21580 denotes A20
T11710 21607-21610 http://www.uniprot.org/uniprot/P21580 denotes A20
T11709 21461-21464 http://www.uniprot.org/uniprot/P21580 denotes A20
T11708 21257-21260 http://www.uniprot.org/uniprot/P21580 denotes A20
T11707 21162-21165 http://www.uniprot.org/uniprot/P21580 denotes A20
T11706 21013-21016 http://www.uniprot.org/uniprot/P21580 denotes A20
T11705 20703-20706 http://www.uniprot.org/uniprot/P21580 denotes A20
T11704 20499-20502 http://www.uniprot.org/uniprot/P21580 denotes A20
T11703 20271-20274 http://www.uniprot.org/uniprot/P21580 denotes A20
T11702 20168-20171 http://www.uniprot.org/uniprot/P21580 denotes A20
T11701 20106-20109 http://www.uniprot.org/uniprot/P21580 denotes A20
T11700 19929-19932 http://www.uniprot.org/uniprot/P21580 denotes A20
T11699 19798-19801 http://www.uniprot.org/uniprot/P21580 denotes A20
T11698 19677-19680 http://www.uniprot.org/uniprot/P21580 denotes A20
T11697 19483-19486 http://www.uniprot.org/uniprot/P21580 denotes A20
T11696 19311-19314 http://www.uniprot.org/uniprot/P21580 denotes A20
T11695 19126-19129 http://www.uniprot.org/uniprot/P21580 denotes A20
T11694 19062-19065 http://www.uniprot.org/uniprot/P21580 denotes A20
T11693 18964-18967 http://www.uniprot.org/uniprot/P21580 denotes A20
T11692 18838-18841 http://www.uniprot.org/uniprot/P21580 denotes A20
T11691 18753-18756 http://www.uniprot.org/uniprot/P21580 denotes A20
T11690 18691-18694 http://www.uniprot.org/uniprot/P21580 denotes A20
T11689 18275-18278 http://www.uniprot.org/uniprot/P21580 denotes A20
T11688 17953-17956 http://www.uniprot.org/uniprot/P21580 denotes A20
T11687 17941-17944 http://www.uniprot.org/uniprot/P21580 denotes A20
T9127 17680-17683 http://www.uniprot.org/uniprot/Q99558 denotes NIK
T9126 17457-17461 http://www.uniprot.org/uniprot/P25963 denotes IκBα
T9125 17437-17441 http://www.uniprot.org/uniprot/O14920 denotes IKK2
T9124 17781-17785 http://www.uniprot.org/uniprot/Q60680-2 denotes IKK1
T9123 17660-17664 http://www.uniprot.org/uniprot/Q60680-2 denotes IKK1
T9122 17480-17484 http://www.uniprot.org/uniprot/Q60680-2 denotes IKK1
T9121 17353-17357 http://www.uniprot.org/uniprot/Q60680-2 denotes IKK1
T9120 17297-17301 http://www.uniprot.org/uniprot/Q60680-2 denotes IKK1
T9119 17069-17073 http://www.uniprot.org/uniprot/Q60680-2 denotes IKK1
T9118 17781-17785 http://www.uniprot.org/uniprot/O15111 denotes IKK1
T9117 17660-17664 http://www.uniprot.org/uniprot/O15111 denotes IKK1
T9116 17480-17484 http://www.uniprot.org/uniprot/O15111 denotes IKK1
T9115 17353-17357 http://www.uniprot.org/uniprot/O15111 denotes IKK1
T9114 17297-17301 http://www.uniprot.org/uniprot/O15111 denotes IKK1
T9113 17069-17073 http://www.uniprot.org/uniprot/O15111 denotes IKK1
T6913 13389-13394 http://www.uniprot.org/uniprot/Q13490 denotes cIAP1
T6912 11276-11281 http://www.uniprot.org/uniprot/Q13490 denotes cIAP1
T6911 15803-15808 http://www.uniprot.org/uniprot/Q12933 denotes TRAF2
T6910 15489-15494 http://www.uniprot.org/uniprot/Q12933 denotes TRAF2
T6909 15415-15420 http://www.uniprot.org/uniprot/Q12933 denotes TRAF2
T6908 13618-13623 http://www.uniprot.org/uniprot/Q12933 denotes TRAF2
T6907 13371-13376 http://www.uniprot.org/uniprot/Q12933 denotes TRAF2
T6906 11264-11269 http://www.uniprot.org/uniprot/Q12933 denotes TRAF2
T6905 12533-12537 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T6904 11405-11409 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T6903 11308-11312 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T6902 11203-11207 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T6901 10935-10939 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T6900 11621-11625 http://www.uniprot.org/uniprot/Q9Y6K9 denotes NEMO
T6899 11515-11519 http://www.uniprot.org/uniprot/Q9Y6K9 denotes NEMO
T6898 8460-8464 http://www.uniprot.org/uniprot/Q9Y6K9 denotes NEMO
T6897 8373-8377 http://www.uniprot.org/uniprot/Q9Y6K9 denotes NEMO
T6896 8313-8317 http://www.uniprot.org/uniprot/O14920 denotes IKKβ
T6895 8284-8288 http://www.uniprot.org/uniprot/O14920 denotes IKK2
T6894 13798-13802 http://www.uniprot.org/uniprot/Q60680-2 denotes IKK1
T6893 13107-13111 http://www.uniprot.org/uniprot/Q60680-2 denotes IKK1
T6892 8474-8478 http://www.uniprot.org/uniprot/Q60680-2 denotes IKK1
T6891 8275-8279 http://www.uniprot.org/uniprot/Q60680-2 denotes IKK1
T6890 8051-8061 http://www.uniprot.org/uniprot/Q60680-2 denotes IκB kinase
T6889 13798-13802 http://www.uniprot.org/uniprot/O15111 denotes IKK1
T6888 13107-13111 http://www.uniprot.org/uniprot/O15111 denotes IKK1
T6887 8474-8478 http://www.uniprot.org/uniprot/O15111 denotes IKK1
T6886 8275-8279 http://www.uniprot.org/uniprot/O15111 denotes IKK1
T6885 8051-8061 http://www.uniprot.org/uniprot/O15111 denotes IκB kinase
T6884 12662-12665 http://www.uniprot.org/uniprot/P01375 denotes TNF
T6883 11680-11683 http://www.uniprot.org/uniprot/P01375 denotes TNF
T6882 11184-11187 http://www.uniprot.org/uniprot/P01375 denotes TNF
T6881 11167-11170 http://www.uniprot.org/uniprot/P01375 denotes TNF
T6880 11006-11009 http://www.uniprot.org/uniprot/P01375 denotes TNF
T6879 10841-10844 http://www.uniprot.org/uniprot/P01375 denotes TNF
T6878 10795-10798 http://www.uniprot.org/uniprot/P01375 denotes TNF
T6877 10782-10785 http://www.uniprot.org/uniprot/P01375 denotes TNF
T6876 7808-7811 http://www.uniprot.org/uniprot/P01375 denotes TNF
T6875 12863-12866 http://www.uniprot.org/uniprot/Q00653 denotes p52
T6874 7473-7476 http://www.uniprot.org/uniprot/Q00653 denotes p52
T6873 7437-7441 http://www.uniprot.org/uniprot/Q00653 denotes p100
T6872 7306-7310 http://www.uniprot.org/uniprot/Q00653 denotes p100
T6871 7481-7484 http://www.uniprot.org/uniprot/P19838 denotes p50
T6870 7446-7450 http://www.uniprot.org/uniprot/P19838 denotes p105
T6869 7277-7281 http://www.uniprot.org/uniprot/P19838 denotes p105
T6868 7446-7450 http://www.uniprot.org/uniprot/Q14511 denotes p105
T6867 7277-7281 http://www.uniprot.org/uniprot/Q14511 denotes p105
T6866 7271-7275 http://www.uniprot.org/uniprot/O00221 denotes IκBε
T6865 7265-7269 http://www.uniprot.org/uniprot/Q15653 denotes IκBβ
T6941 15780-15784 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T6940 15340-15352 http://www.uniprot.org/uniprot/P29965 denotes ligand, CD40
T6939 15850-15855 http://www.uniprot.org/uniprot/Q13114 denotes TRAF3
T6938 15499-15504 http://www.uniprot.org/uniprot/Q13114 denotes TRAF3
T6937 15422-15427 http://www.uniprot.org/uniprot/Q13114 denotes TRAF3
T6936 13672-13677 http://www.uniprot.org/uniprot/Q13114 denotes TRAF3
T6935 13540-13545 http://www.uniprot.org/uniprot/Q13114 denotes TRAF3
T6934 13378-13383 http://www.uniprot.org/uniprot/Q13114 denotes TRAF3
T6933 13777-13780 http://www.uniprot.org/uniprot/Q99558 denotes NIK
T6932 13725-13728 http://www.uniprot.org/uniprot/Q99558 denotes NIK
T6931 13426-13429 http://www.uniprot.org/uniprot/Q99558 denotes NIK
T6930 13330-13333 http://www.uniprot.org/uniprot/Q99558 denotes NIK
T6929 13185-13188 http://www.uniprot.org/uniprot/Q99558 denotes NIK
T6928 13179-13182 http://www.uniprot.org/uniprot/Q99558 denotes NIK
T6927 12892-12896 http://www.uniprot.org/uniprot/Q01201 denotes RelB
T6926 15890-15894 http://www.uniprot.org/uniprot/P25942 denotes CD40
T6925 15747-15751 http://www.uniprot.org/uniprot/P25942 denotes CD40
T6924 15676-15680 http://www.uniprot.org/uniprot/P25942 denotes CD40
T6923 15348-15352 http://www.uniprot.org/uniprot/P25942 denotes CD40
T6922 15195-15199 http://www.uniprot.org/uniprot/P25942 denotes CD40
T6921 12780-12784 http://www.uniprot.org/uniprot/P25942 denotes CD40
T6920 15725-15730 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TRAF6
T6919 15440-15445 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TRAF6
T6918 12518-12523 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TRAF6
T6917 12487-12492 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TRAF6
T6916 12427-12432 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TRAF6
T6915 11994-11998 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T6914 13628-13633 http://www.uniprot.org/uniprot/Q13490 denotes cIAP1
T3287 6565-6569 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T3286 6099-6103 http://www.uniprot.org/uniprot/O00206 denotes TLR4
T3285 4302-4305 http://www.uniprot.org/uniprot/P01730 denotes CD4
T3284 4532-4537 http://www.uniprot.org/uniprot/P29965 denotes CD154
T3283 4235-4240 http://www.uniprot.org/uniprot/P29965 denotes CD154
T3282 4222-4233 http://www.uniprot.org/uniprot/P29965 denotes CD40 ligand
T3281 4576-4580 http://www.uniprot.org/uniprot/P25942 denotes CD40
T3280 4519-4523 http://www.uniprot.org/uniprot/P25942 denotes CD40
T3279 4222-4226 http://www.uniprot.org/uniprot/P25942 denotes CD40
T3278 3903-3907 http://www.uniprot.org/uniprot/P25942 denotes CD40
T3277 4783-4786 http://www.uniprot.org/uniprot/P01375 denotes TNF
T3276 4197-4200 http://www.uniprot.org/uniprot/P01375 denotes TNF
T3275 3919-3922 http://www.uniprot.org/uniprot/P01375 denotes TNF
T3274 3702-3705 http://www.uniprot.org/uniprot/P01375 denotes TNF
T3273 3450-3453 http://www.uniprot.org/uniprot/P01375 denotes TNF
T3272 3375-3378 http://www.uniprot.org/uniprot/P01375 denotes TNF
T3271 3316-3319 http://www.uniprot.org/uniprot/P01375 denotes TNF
T1278 2953-2960 http://www.uniprot.org/uniprot/P21580 denotes TNFAIP3
T1277 2940-2944 http://www.uniprot.org/uniprot/P25942 denotes CD40
T1276 1895-1899 http://www.uniprot.org/uniprot/P05231 denotes IL-6
T1275 2035-2038 http://www.uniprot.org/uniprot/P01375 denotes TNF
T1274 1884-1887 http://www.uniprot.org/uniprot/P01375 denotes TNF
T1273 2968-2971 http://www.uniprot.org/uniprot/Q04864 denotes REL
T1272 1758-1763 http://www.uniprot.org/uniprot/Q04864 denotes c-Rel
T1271 1752-1756 http://www.uniprot.org/uniprot/Q01201 denotes RelB
T1270 1739-1742 http://www.uniprot.org/uniprot/P21579 denotes p65
T1269 1739-1742 http://www.uniprot.org/uniprot/Q04206 denotes p65
T1268 1723-1727 http://www.uniprot.org/uniprot/P19838 denotes p105
T1267 1723-1727 http://www.uniprot.org/uniprot/Q14511 denotes p105
T1266 1707-1711 http://www.uniprot.org/uniprot/Q00653 denotes p100

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T21531 15143-15165 Protein denotes tumour necrosis factor
T21530 15138-15141 Protein denotes TNF
T21529 15071-15098 Protein denotes receptor activator of NF-κB
T21528 15065-15069 Protein denotes RANK
T21527 14846-14851 Protein denotes TRAF1
T21526 14839-14844 Protein denotes TRAF3
T21525 14799-14803 Protein denotes RelB
T21524 14763-14766 Protein denotes p52
T21523 14755-14759 Protein denotes p100
T21522 14644-14648 Protein denotes p100
T21521 14617-14621 Protein denotes IKK1
T21520 14579-14582 Protein denotes NIK
T21519 14555-14558 Protein denotes NIK
T21518 14513-14516 Protein denotes NIK
T21517 14491-14496 Protein denotes TRAF3
T21516 14473-14476 Protein denotes NIK
T21515 14454-14459 Protein denotes TRAF3
T21514 14407-14408 Protein denotes 2
T21513 14401-14406 Protein denotes cIAP1
T21512 14354-14355 Protein denotes 2
T21511 14348-14353 Protein denotes cIAP1
T21510 14286-14291 Protein denotes TRAF2
T21509 14244-14249 Protein denotes TRAF3
T21508 14207-14210 Protein denotes NIK
T21507 14194-14197 Protein denotes NIK
T21506 14108-14109 Protein denotes 2
T21505 14102-14107 Protein denotes cIAP1
T21504 14092-14097 Protein denotes TRAF3
T21503 14085-14090 Protein denotes TRAF2
T21502 14028-14031 Protein denotes NIK
T21501 13982-13985 Protein denotes NIK
T21500 13959-13980 Protein denotes NF-κB inducing kinase
T21499 13889-13893 Protein denotes RANK
T21498 13880-13884 Protein denotes CD40
T19639 10701-10723 Protein denotes tumour necrosis factor
T19638 10696-10699 Protein denotes TNF
T19637 10558-10600 Protein denotes single-immunoglobulinIL-1 receptor-related
T19636 10550-10556 Protein denotes SIGIRR
T19635 10518-10548 Protein denotes receptor interacting protein 1
T19634 10512-10516 Protein denotes RIP1
T19633 10483-10510 Protein denotes receptor activator of NF-κB
T19632 10477-10481 Protein denotes RANK
T19631 10430-10455 Protein denotes NF-κB essential modulator
T19630 10424-10428 Protein denotes NEMO
T19629 10374-10422 Protein denotes myeloid differentiation primary response gene 88
T19628 10367-10372 Protein denotes MyD88
T19627 10277-10292 Protein denotes cylindromatosis
T19626 10271-10275 Protein denotes CYLD
T19625 10200-10230 Protein denotes A20-binding inhibitor of NF-κB
T19624 10194-10198 Protein denotes ABIN
T19623 10031-10036 Protein denotes TRAF6
T19622 10021-10026 Protein denotes IRAK1
T19621 10001-10005 Protein denotes TLR4
T19620 9953-9959 Protein denotes SIGIRR
T19619 9871-9876 Protein denotes TRAF6
T19618 9861-9866 Protein denotes IRAK1
T19617 9771-9774 Protein denotes p62
T19616 9760-9766 Protein denotes ABIN-1
T19615 9667-9672 Protein denotes TRAF6
T19614 9658-9662 Protein denotes RIP1
T19613 9542-9546 Protein denotes CYLD
T19612 9534-9537 Protein denotes A20
T19611 9400-9405 Protein denotes TRAF1
T19610 9329-9332 Protein denotes p50
T19609 9321-9324 Protein denotes p65
T19608 9195-9199 Protein denotes IκBα
T19607 9160-9164 Protein denotes IKK2
T19606 9121-9125 Protein denotes TAK1
T19605 9115-9119 Protein denotes TAK1
T19604 9106-9110 Protein denotes IKK2
T19603 9023-9027 Protein denotes NEMO
T19602 8999-9004 Protein denotes IRAK1
T19601 8990-8994 Protein denotes RIP1
T19600 8926-8931 Protein denotes cIAP2
T19599 8919-8924 Protein denotes cIAP1
T19598 8912-8917 Protein denotes TRAF6
T19597 8905-8910 Protein denotes TRAF2
T19596 8874-8879 Protein denotes IRAK4
T19595 8867-8872 Protein denotes IRAK1
T19594 8861-8865 Protein denotes RIP1
T19593 8844-8848 Protein denotes TRIF
T19592 8799-8842 Protein denotes TIR domain-containing adaptor-inducing IFNβ
T19591 8794-8797 Protein denotes MAL
T19590 8787-8792 Protein denotes MyD88
T19589 8779-8784 Protein denotes TRADD
T19588 8731-8777 Protein denotes TNF receptor 1-associated death domain protein
T19587 8672-8676 Protein denotes TLR4
T19586 8662-8666 Protein denotes RANK
T19585 8656-8660 Protein denotes CD40
T19584 8649-8654 Protein denotes TNFR1
T17520 30853-30858 Protein denotes TRAF6
T17519 30843-30848 Protein denotes IRAK1
T17518 30771-30779 Protein denotes miR-146a
T17517 30736-30739 Protein denotes TNF
T17516 30729-30734 Protein denotes IL-1β
T17515 30590-30597 Protein denotes miR-155
T17514 30584-30585 Protein denotes b
T17513 30575-30583 Protein denotes miR-146a
T17542 32659-32666 Protein denotes miR-223
T17541 32646-32653 Protein denotes miR-132
T17540 32638-32644 Protein denotes miR-16
T17539 32575-32579 Protein denotes IL-6
T17538 32544-32570 Protein denotes matrix metalloproteinase-1
T17537 32500-32507 Protein denotes miR-203
T17536 32368-32402 Protein denotes monocyte chemoattractant protein 1
T17535 32324-32332 Protein denotes miR-124a
T17534 32152-32159 Protein denotes miR-155
T17533 31754-31761 Protein denotes miR-155
T17532 31680-31683 Protein denotes TNF
T17531 31651-31658 Protein denotes miR-155
T17530 31450-31457 Protein denotes miR-155
T17529 31364-31372 Protein denotes miR-146a
T17528 31263-31268 Protein denotes IL-17
T17527 31254-31257 Protein denotes CD4
T17526 31220-31228 Protein denotes miR-146a
T17525 31055-31062 Protein denotes miR-155
T17524 31015-31019 Protein denotes RIP1
T17523 31006-31010 Protein denotes IKKε
T17522 30931-30938 Protein denotes miR-155
T17521 30894-30902 Protein denotes miR-146a
T16429 30190-30195 Protein denotes TRAF1
T16428 30057-30062 Protein denotes TRAF1
T16427 29955-29960 Protein denotes TRAF1
T16426 29728-29731 Protein denotes A20
T16425 29708-29713 Protein denotes TRAF1
T16424 29595-29600 Protein denotes TRAF1
T16423 29528-29533 Protein denotes TRAF1
T16422 29426-29431 Protein denotes TRAF2
T16421 29330-29335 Protein denotes TRAF1
T16420 29299-29303 Protein denotes CD40
T16419 29251-29256 Protein denotes TRAF1
T16418 29170-29173 Protein denotes TNF
T16417 29122-29127 Protein denotes TRAF1
T16416 29092-29095 Protein denotes TNF
T16415 29077-29082 Protein denotes TRAF1
T16414 29051-29054 Protein denotes TNF
T16413 29029-29034 Protein denotes TRAF1
T16412 28862-28867 Protein denotes TRAF1
T16411 28798-28807 Protein denotes ubiquitin
T16410 28688-28693 Protein denotes TRAF1
T16409 28655-28687 Protein denotes TNF receptor-associated factor 1
T15546 28594-28600 Protein denotes SIGIRR
T15545 28510-28516 Protein denotes SIGIRR
T15544 28405-28411 Protein denotes SIGIRR
T15543 28212-28218 Protein denotes SIGIRR
T15542 28168-28174 Protein denotes SIGIRR
T15541 28019-28025 Protein denotes SIGIRR
T15540 27843-27849 Protein denotes SIGIRR
T15539 27813-27819 Protein denotes SIGIRR
T15538 27717-27722 Protein denotes IL-1R
T15537 27666-27671 Protein denotes TRAF6
T15536 27657-27662 Protein denotes IRAK1
T15535 27650-27655 Protein denotes MyD88
T15534 27566-27571 Protein denotes IL-1R
T15533 27464-27469 Protein denotes TIR-8
T15532 27433-27439 Protein denotes SIGIRR
T15531 27388-27431 Protein denotes Single-immunoglobulin IL-1 receptor-related
T14243 27244-27248 Protein denotes CYLD
T14242 27135-27139 Protein denotes RANK
T14241 27106-27110 Protein denotes CYLD
T14240 26993-26996 Protein denotes p62
T14239 26896-26901 Protein denotes TRAF6
T14238 26862-26866 Protein denotes CYLD
T14237 26824-26838 Protein denotes sequestosome 1
T14236 26805-26808 Protein denotes p62
T14235 26771-26780 Protein denotes ubiquitin
T14234 26757-26762 Protein denotes TRAF6
T14233 26690-26695 Protein denotes RANKL
T14232 26630-26634 Protein denotes CYLD
T14231 26559-26564 Protein denotes RANKL
T14230 26420-26424 Protein denotes CYLD
T14229 26333-26337 Protein denotes RANK
T14228 26290-26294 Protein denotes CYLD
T14227 26143-26147 Protein denotes CYLD
T14226 25985-25988 Protein denotes A20
T14225 25948-25952 Protein denotes CYLD
T14224 25933-25936 Protein denotes A20
T14223 25884-25887 Protein denotes A20
T14222 25843-25847 Protein denotes TAK1
T14221 25834-25838 Protein denotes RIP1
T14220 25827-25832 Protein denotes TRAF7
T14219 25820-25825 Protein denotes TRAF6
T14218 25813-25818 Protein denotes TRAF2
T14217 25807-25811 Protein denotes NEMO
T14216 25674-25678 Protein denotes RANK
T14215 25588-25611 Protein denotes deubiquitinating enzyme
T14214 25578-25582 Protein denotes CYLD
T14213 25385-25389 Protein denotes CYLD
T14212 25279-25283 Protein denotes CYLD
T14211 25262-25277 Protein denotes Cylindromatosis
T14210 25238-25253 Protein denotes Cylindromatosis
T12736 24679-24685 Protein denotes ABIN-1
T12735 24537-24540 Protein denotes A20
T12734 24526-24532 Protein denotes ABIN-3
T12733 24239-24242 Protein denotes A20
T12732 24217-24223 Protein denotes ABIN-1
T12731 24136-24142 Protein denotes ABIN-1
T12730 24076-24079 Protein denotes TNF
T12729 24048-24054 Protein denotes ABIN-1
T12728 23962-23965 Protein denotes TNF
T12727 23915-23921 Protein denotes ABIN-1
T12726 23883-23886 Protein denotes TNF
T12725 23853-23859 Protein denotes ABIN-1
T12724 23848-23851 Protein denotes A20
T12723 23762-23789 Protein denotes truncated and inactive form
T12722 23707-23713 Protein denotes ABIN-3
T12721 23516-23522 Protein denotes ABIN-2
T12720 23495-23501 Protein denotes ABIN-1
T12719 23383-23386 Protein denotes A20
T12718 23308-23314 Protein denotes ABIN-3
T12717 23297-23303 Protein denotes ABIN-1
T12716 23292-23295 Protein denotes A20
T12715 23236-23239 Protein denotes A20
T12714 23080-23083 Protein denotes TNF
T12713 23009-23012 Protein denotes A20
T12712 22959-22965 Protein denotes TNIP-3
T12711 22947-22953 Protein denotes TNIP-2
T12710 22939-22945 Protein denotes TNIP-1
T12709 22917-22923 Protein denotes ABIN-3
T12708 22906-22912 Protein denotes ABIN-2
T12707 22898-22904 Protein denotes ABIN-1
T12706 22866-22869 Protein denotes A20
T9786 19643-19646 Protein denotes TNF
T9785 19483-19486 Protein denotes A20
T9784 19360-19363 Protein denotes TNF
T9783 19311-19314 Protein denotes A20
T9782 19126-19129 Protein denotes A20
T9781 19062-19065 Protein denotes A20
T9780 18964-18967 Protein denotes A20
T9779 18882-18904 Protein denotes Tax1-binding protein 1
T9778 18838-18877 Protein denotes A20-binding inhibitor of NF-κB (ABIN) 1
T9777 18753-18756 Protein denotes A20
T9776 18691-18694 Protein denotes A20
T9775 18634-18635 Protein denotes 2
T9774 18628-18633 Protein denotes cIAP1
T9773 18618-18623 Protein denotes TRAF2
T9772 18611-18616 Protein denotes TRAF6
T9771 18577-18583 Protein denotes Ubc5hc
T9770 18567-18572 Protein denotes Ubc13
T9769 18404-18409 Protein denotes MALT1
T9768 18394-18399 Protein denotes TRAF6
T9767 18388-18392 Protein denotes RIP2
T9766 18382-18386 Protein denotes RIP1
T9765 18275-18278 Protein denotes A20
T9764 18132-18135 Protein denotes TNF
T9763 18038-18043 Protein denotes NF-κB
T9762 17986-18011 Protein denotes ubiquitin-editing protein
T9761 17972-17979 Protein denotes TNFAIP3
T9760 17953-17956 Protein denotes A20
T9759 17941-17944 Protein denotes A20
T9820 22791-22794 Protein denotes A20
T9819 22555-22558 Protein denotes A20
T9818 22507-22510 Protein denotes A20
T9817 22327-22330 Protein denotes A20
T9816 22246-22249 Protein denotes A20
T9815 22208-22216 Protein denotes cytokine
T9814 22176-22179 Protein denotes TNF
T9813 22151-22154 Protein denotes TNF
T9812 22116-22119 Protein denotes A20
T9811 22029-22032 Protein denotes A20
T9810 21982-21985 Protein denotes A20
T9809 21828-21831 Protein denotes A20
T9808 21607-21610 Protein denotes A20
T9807 21461-21464 Protein denotes A20
T9806 21257-21260 Protein denotes A20
T9805 21162-21165 Protein denotes A20
T9804 21013-21016 Protein denotes A20
T9803 21004-21009 Protein denotes IL-1β
T9802 20996-20999 Protein denotes TNF
T9801 20869-20874 Protein denotes IL-1β
T9800 20861-20864 Protein denotes TNF
T9799 20703-20706 Protein denotes A20
T9798 20639-20674 Protein denotes monocyte chemo-attractant protein 1
T9797 20632-20637 Protein denotes RANKL
T9796 20618-20622 Protein denotes IL-6
T9795 20611-20616 Protein denotes IL-1β
T9794 20606-20609 Protein denotes TNF
T9793 20499-20502 Protein denotes A20
T9792 20271-20274 Protein denotes A20
T9791 20168-20171 Protein denotes A20
T9790 20106-20109 Protein denotes A20
T9789 19929-19932 Protein denotes A20
T9788 19798-19801 Protein denotes A20
T9787 19677-19680 Protein denotes A20
T4563 15489-15494 Protein denotes TRAF2
T4562 15440-15445 Protein denotes TRAF6
T4561 15429-15434 Protein denotes TRAF5
T4560 15422-15427 Protein denotes TRAF3
T4559 15415-15420 Protein denotes TRAF2
T4558 15408-15413 Protein denotes TRAF1
T4557 15357-15361 Protein denotes RANK
T4556 15348-15352 Protein denotes CD40
T4555 15228-15232 Protein denotes RANK
T4554 15201-15223 Protein denotes lymphotoxin β receptor
T4553 15195-15199 Protein denotes CD40
T4552 13798-13802 Protein denotes IKK1
T4551 13777-13780 Protein denotes NIK
T4550 13725-13728 Protein denotes NIK
T4549 13672-13677 Protein denotes TRAF3
T4548 13634-13635 Protein denotes 2
T4547 13628-13633 Protein denotes cIAP1
T4546 13618-13623 Protein denotes TRAF2
T4545 13540-13545 Protein denotes TRAF3
T4544 13426-13429 Protein denotes NIK
T4543 13395-13396 Protein denotes 2
T4542 13389-13394 Protein denotes cIAP1
T4541 13378-13383 Protein denotes TRAF3
T4540 13371-13376 Protein denotes TRAF2
T4539 13330-13333 Protein denotes NIK
T4538 13185-13188 Protein denotes NIK
T4537 13179-13182 Protein denotes NIK
T4536 13156-13177 Protein denotes NF-κB inducing kinase
T4535 13107-13111 Protein denotes IKK1
T4534 12892-12896 Protein denotes RelB
T4533 12863-12866 Protein denotes p52
T4532 12824-12828 Protein denotes p100
T4531 12790-12794 Protein denotes RANK
T4530 12780-12784 Protein denotes CD40
T4529 12765-12778 Protein denotes BAFF receptor
T4528 12741-12763 Protein denotes lymphotoxin β receptor
T4527 12662-12665 Protein denotes TNF
T4526 12597-12601 Protein denotes TAK1
T4525 12533-12537 Protein denotes RIP1
T4524 12518-12523 Protein denotes TRAF6
T4523 12499-12503 Protein denotes TRIF
T4522 12487-12492 Protein denotes TRAF6
T4521 12427-12432 Protein denotes TRAF6
T4520 12347-12352 Protein denotes MyD88
T4519 12326-12330 Protein denotes TRIF
T4518 12281-12324 Protein denotes TIR domain-containing adaptor-inducing IFNβ
T4517 12270-12275 Protein denotes MyD88
T4516 12220-12268 Protein denotes myeloid differentiation primary response gene 88
T4515 12156-12160 Protein denotes TRAM
T4514 12125-12154 Protein denotes TRIF-related adaptor molecule
T4513 12116-12118 Protein denotes Ma
T4512 12060-12094 Protein denotes Toll/IL-1 receptor adaptor protein
T4511 11994-11998 Protein denotes TLR4
T4510 11906-11910 Protein denotes TAK1
T4509 11680-11683 Protein denotes TNF
T4508 11621-11625 Protein denotes NEMO
T4507 11529-11530 Protein denotes 2
T4506 11524-11528 Protein denotes TAB1
T4505 11515-11519 Protein denotes NEMO
T4504 11467-11471 Protein denotes TAK1
T4503 11405-11409 Protein denotes RIP1
T4502 11308-11312 Protein denotes RIP1
T4501 11282-11283 Protein denotes 2
T4500 11276-11281 Protein denotes cIAP1
T4499 11270-11271 Protein denotes 5
T4498 11264-11269 Protein denotes TRAF2
T4497 11203-11207 Protein denotes RIP1
T4496 11167-11170 Protein denotes TNF
T4495 11146-11151 Protein denotes cIAP2
T4494 11101-11141 Protein denotes cellular inhibitor of apoptosis (cIAP) 1
T4493 11050-11055 Protein denotes TRAF5
T4492 11006-11045 Protein denotes TNF receptor-associated factor (TRAF) 2
T4491 10935-10939 Protein denotes RIP1
T4490 10903-10933 Protein denotes receptor interacting protein 1
T4489 10881-10886 Protein denotes TRADD
T4488 10841-10879 Protein denotes TNF receptor-1-associated death domain
T4487 10795-10798 Protein denotes TNF
T4486 10782-10785 Protein denotes TNF
T4485 8474-8478 Protein denotes IKK1
T4484 8460-8464 Protein denotes NEMO
T4483 8451-8455 Protein denotes IKK2
T4482 8394-8398 Protein denotes IKKγ
T4481 8373-8377 Protein denotes NEMO
T4480 8346-8371 Protein denotes NF-κB essential modulator
T4479 8313-8317 Protein denotes IKKβ
T4478 8304-8308 Protein denotes IKKα
T4477 8284-8288 Protein denotes IKK2
T4476 8275-8279 Protein denotes IKK1
T4475 7830-7835 Protein denotes RANKL
T4474 7808-7811 Protein denotes TNF
T4473 7481-7484 Protein denotes p50
T4472 7473-7476 Protein denotes p52
T4471 7446-7450 Protein denotes p105
T4470 7437-7441 Protein denotes p100
T4469 7374-7379 Protein denotes Bcl-3
T4468 7365-7369 Protein denotes IκBξ
T4467 7326-7332 Protein denotes NF-κB2
T4466 7306-7310 Protein denotes p100
T4465 7297-7303 Protein denotes NF-κB1
T4464 7277-7281 Protein denotes p105
T4463 7271-7275 Protein denotes IκBε
T4462 7265-7269 Protein denotes IκBβ
T4461 7259-7263 Protein denotes IκBα
T1846 6759-6769 Protein denotes tenascin C
T1845 6749-6757 Protein denotes biglycan
T1844 6736-6747 Protein denotes fibronectin
T1843 6565-6569 Protein denotes TLR4
T1842 6341-6367 Protein denotes myeloid-related protein 14
T1841 6311-6336 Protein denotes Myeloid-related protein 8
T1840 6248-6253 Protein denotes HMGB1
T1839 6183-6188 Protein denotes HMGB1
T1838 6138-6143 Protein denotes HMGB1
T1837 6099-6111 Protein denotes TLR4 ligands
T1836 5954-5973 Protein denotes chromatin component
T1835 5927-5932 Protein denotes HMGB1
T1834 5880-5925 Protein denotes High mobility group box chromosomal protein 1
T1833 5011-5033 Protein denotes lymphotoxin β receptor
T1832 4957-4961 Protein denotes BAFF
T1831 4836-4840 Protein denotes BAFF
T1830 4810-4834 Protein denotes B-cell activating factor
T1829 4576-4580 Protein denotes CD40
T1828 4302-4305 Protein denotes CD4
T1827 4235-4240 Protein denotes CD154
T1826 4222-4233 Protein denotes CD40 ligand
T1825 4197-4200 Protein denotes TNF
T1824 3919-3945 Protein denotes TNF receptor family member
T1823 3903-3907 Protein denotes CD40
T1822 3789-3793 Protein denotes RANK
T1821 3693-3697 Protein denotes RANK
T1820 3664-3691 Protein denotes receptor activator of NF-κB
T1819 3450-3453 Protein denotes TNF
T1818 3375-3378 Protein denotes TNF
T1817 3316-3319 Protein denotes TNF
T373 2966-2971 Protein denotes c-REL
T372 2953-2960 Protein denotes TNFAIP3
T371 2946-2951 Protein denotes TRAF1
T370 2940-2944 Protein denotes CD40
T369 2690-2695 Protein denotes RANKL
T368 2654-2688 Protein denotes receptor activator of NF-κB ligand
T367 2035-2038 Protein denotes TNF
T366 1932-1963 Protein denotes inducible nitric oxide synthase
T365 1901-1918 Protein denotes cyclo-oxygenase-2
T364 1895-1899 Protein denotes IL-6
T363 1884-1887 Protein denotes TNF
T362 1758-1763 Protein denotes c-Rel
T361 1752-1756 Protein denotes RelB
T360 1746-1750 Protein denotes RelA
T359 1739-1742 Protein denotes p65
T358 1731-1737 Protein denotes NF-κB1
T357 1723-1727 Protein denotes p105
T356 1715-1721 Protein denotes NF-κB2
T355 1707-1711 Protein denotes p100
T4566 15725-15730 Protein denotes TRAF6
T4565 15676-15680 Protein denotes CD40
T4564 15499-15504 Protein denotes TRAF3
T15530 27336-27379 Protein denotes Single-immunoglobulin IL-1 receptor-related
T8425 17781-17785 Protein denotes IKK1
T8424 17680-17683 Protein denotes NIK
T8423 17660-17664 Protein denotes IKK1
T8422 17596-17601 Protein denotes STAT1
T8421 17480-17484 Protein denotes IKK1
T8420 17457-17461 Protein denotes IκBα
T8419 17437-17441 Protein denotes IKK2
T8418 17353-17357 Protein denotes IKK1
T8417 17297-17301 Protein denotes IKK1
T8416 17069-17073 Protein denotes IKK1
T8415 16915-16921 Protein denotes TOLLIP
T8414 16903-16909 Protein denotes IRAK-M
T8413 16895-16901 Protein denotes MyD88s
T4571 15890-15894 Protein denotes CD40
T4570 15850-15855 Protein denotes TRAF3
T4569 15803-15808 Protein denotes TRAF2
T4568 15780-15784 Protein denotes IL-6
T4567 15747-15751 Protein denotes CD40

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T21497 14649-14664 Antecedent denotes phosphorylation
T21496 14666-14670 Anaphor denotes This
T21495 14617-14621 Antecedent denotes IKK1
T21494 14623-14628 Anaphor denotes which
T21493 14354-14355 Antecedent denotes 2
T21492 14348-14353 Antecedent denotes cIAP1
T21491 14370-14375 Anaphor denotes their
T21490 14092-14097 Antecedent denotes TRAF3
T21489 14085-14090 Antecedent denotes TRAF2
T21488 14111-14116 Anaphor denotes which
T19583 9953-9959 Antecedent denotes SIGIRR
T19582 9961-9966 Anaphor denotes which
T19581 9771-9774 Antecedent denotes p62
T19580 9760-9766 Antecedent denotes ABIN-1
T19579 9735-9751 Anaphor denotes adaptor proteins
T19578 9542-9546 Antecedent denotes CYLD
T19577 9534-9537 Antecedent denotes A20
T19576 9683-9687 Anaphor denotes they
T19575 9195-9199 Antecedent denotes IκBα
T19574 9212-9215 Anaphor denotes its
T19573 8672-8676 Antecedent denotes TLR4
T19572 8662-8666 Antecedent denotes RANK
T19571 8656-8660 Antecedent denotes CD40
T19570 8649-8654 Antecedent denotes TNFR1
T19569 8622-8640 Anaphor denotes membrane receptors
T17512 31754-31761 Antecedent denotes miR-155
T17511 31918-31923 Anaphor denotes their
T17510 30590-30597 Antecedent denotes miR-155
T17509 30669-30681 Anaphor denotes these miRNAs
T16408 29708-29713 Antecedent denotes TRAF1
T16407 29743-29745 Anaphor denotes it
T15529 28594-28600 Antecedent denotes SIGIRR
T15528 28559-28562 Anaphor denotes its
T15527 28405-28411 Antecedent denotes SIGIRR
T15526 28432-28435 Anaphor denotes its
T15525 27566-27571 Antecedent denotes IL-1R
T15524 27633-27648 Anaphor denotes these receptors
T15523 27464-27469 Antecedent denotes TIR-8
T15522 27507-27511 Anaphor denotes that
T14209 25843-25847 Antecedent denotes TAK1
T14208 25834-25838 Antecedent denotes RIP1
T14207 25827-25832 Antecedent denotes TRAF7
T14206 25820-25825 Antecedent denotes TRAF6
T14205 25813-25818 Antecedent denotes TRAF2
T14204 25807-25811 Antecedent denotes NEMO
T14203 25857-25862 Anaphor denotes these
T16406 29728-29731 Antecedent denotes A20
T16405 29737-29742 Anaphor denotes which
T1811 3946-3950 Anaphor denotes that
T1816 5954-5973 Antecedent denotes chromatin component
T1815 5974-5978 Anaphor denotes that
T1814 4222-4233 Antecedent denotes CD40 ligand
T1813 4243-4248 Anaphor denotes which
T1812 3903-3907 Antecedent denotes CD40
T4460 13725-13728 Antecedent denotes NIK
T4459 13734-13737 Anaphor denotes its
T4458 13540-13545 Antecedent denotes TRAF3
T4457 13578-13580 Anaphor denotes it
T4456 13426-13429 Antecedent denotes NIK
T4455 13442-13445 Anaphor denotes its
T4454 13107-13111 Antecedent denotes IKK1
T4453 13113-13118 Anaphor denotes which
T4452 11050-11055 Antecedent denotes TRAF5
T4451 11006-11045 Antecedent denotes TNF receptor-associated factor (TRAF) 2
T4450 11057-11062 Anaphor denotes which
T4449 10903-10933 Antecedent denotes receptor interacting protein 1
T4448 10841-10879 Antecedent denotes TNF receptor-1-associated death domain
T4447 10942-10947 Anaphor denotes which
R3025 T4447 T4448 boundBy which,TNF receptor-1-associated death domain
R3026 T4447 T4449 boundBy which,receptor interacting protein 1
R3027 T4450 T4451 boundBy which,TNF receptor-associated factor (TRAF) 2
R3028 T4450 T4452 boundBy which,TRAF5
R3029 T4453 T4454 boundBy which,IKK1
R3030 T4455 T4456 boundBy its,NIK
R3031 T4457 T4458 boundBy it,TRAF3
R3032 T4459 T4460 boundBy its,NIK
R9341 T14203 T14204 boundBy these,NEMO
R9342 T14203 T14205 boundBy these,TRAF2
R9343 T14203 T14206 boundBy these,TRAF6
R9344 T14203 T14207 boundBy these,TRAF7
R9345 T14203 T14208 boundBy these,RIP1
R9346 T14203 T14209 boundBy these,TAK1
R10198 T15522 T15523 boundBy that,TIR-8
R10199 T15524 T15525 boundBy these receptors,IL-1R
R10200 T15526 T15527 boundBy its,SIGIRR
R10201 T15528 T15529 boundBy its,SIGIRR
R12918 T19569 T19570 boundBy membrane receptors,TNFR1
R12919 T19569 T19571 boundBy membrane receptors,CD40
R12920 T19569 T19572 boundBy membrane receptors,RANK
R12921 T19569 T19573 boundBy membrane receptors,TLR4
R12922 T19574 T19575 boundBy its,IκBα
R12923 T19576 T19577 boundBy they,A20
R12924 T19576 T19578 boundBy they,CYLD
R12925 T19579 T19580 boundBy adaptor proteins,ABIN-1
R12926 T19579 T19581 boundBy adaptor proteins,p62
R12927 T19582 T19583 boundBy which,SIGIRR
R14003 T21488 T21489 boundBy which,TRAF2
R14004 T21488 T21490 boundBy which,TRAF3
R14005 T21491 T21492 boundBy their,cIAP1
R14006 T21491 T21493 boundBy their,2
R14007 T21494 T21495 boundBy which,IKK1
R14008 T21496 T21497 boundBy This,phosphorylation
R1311 T1811 T1812 boundBy that,CD40
R1312 T1813 T1814 boundBy which,CD40 ligand
R1313 T1815 T1816 boundBy that,chromatin component
R10778 T16405 T16406 boundBy which,A20
R10779 T16407 T16408 boundBy it,TRAF1
R11438 T17509 T17510 boundBy these miRNAs,miR-155
R11439 T17511 T17512 boundBy their,miR-155

2_test

Id Subject Object Predicate Lexical cue
21639951-18267068-4289426 1810-1811 18267068 denotes 1
21639951-18982160-4289427 2111-2112 18982160 denotes 3
21639951-18853343-4289428 2361-2362 18853343 denotes 4
21639951-9892501-4289429 2512-2513 9892501 denotes 5
21639951-15899029-4289430 2514-2515 15899029 denotes 6
21639951-16356770-4289431 2817-2818 16356770 denotes 7
21639951-20192992-4289432 3046-3047 20192992 denotes 8
21639951-19798034-4289433 3445-3446 19798034 denotes 9
21639951-18982160-4289434 3639-3640 18982160 denotes 3
21639951-16356770-4289435 3899-3900 16356770 denotes 7
21639951-8973616-4289436 4202-4204 8973616 denotes 10
21639951-7689748-4289437 4748-4750 7689748 denotes 11
21639951-11083282-4289438 4751-4753 11083282 denotes 12
21639951-18771589-4289439 4997-4999 18771589 denotes 13
21639951-18771589-4289440 5149-5151 18771589 denotes 13
21639951-19772831-4289441 5558-5560 19772831 denotes 14
21639951-20629986-4289442 5561-5563 20629986 denotes 15
21639951-12847700-4289443 6306-6308 12847700 denotes 16
21639951-10728757-4289444 6606-6608 10728757 denotes 17
21639951-17767165-4289445 6609-6611 17767165 denotes 18
21639951-19772831-4289446 6816-6818 19772831 denotes 14
21639951-20629986-4289447 6819-6821 20629986 denotes 15
21639951-19302050-4289448 7224-7226 19302050 denotes 19
21639951-21135871-4289449 8211-8213 21135871 denotes 20
21639951-16470223-4289450 8525-8527 16470223 denotes 21
21639951-19136968-4289451 11736-11738 19136968 denotes 22
21639951-19675569-4289452 11920-11922 19675569 denotes 23
21639951-18438411-4289453 12494-12496 18438411 denotes 24
21639951-16306937-4289454 12525-12527 16306937 denotes 25
21639951-16115877-4289455 12539-12541 16115877 denotes 26
21639951-21173796-4289456 13047-13049 21173796 denotes 27
21639951-11520989-4289457 13820-13822 11520989 denotes 28
21639951-15140882-4289458 13823-13825 15140882 denotes 29
21639951-21041727-4289459 15907-15909 21041727 denotes 30
21639951-20348096-4289460 15910-15912 20348096 denotes 31
21639951-19233657-4289461 16458-16460 19233657 denotes 32
21639951-15928677-4289462 16957-16959 15928677 denotes 33
21639951-15858576-4289463 17475-17477 15858576 denotes 34
21639951-17540171-4289464 17603-17605 17540171 denotes 35
21639951-20501937-4289465 17751-17753 20501937 denotes 36
21639951-19008218-4289466 18269-18271 19008218 denotes 37
21639951-15258597-4289467 18465-18467 15258597 denotes 38
21639951-18342009-4289467 18465-18467 18342009 denotes 38
21639951-15334086-4289467 18465-18467 15334086 denotes 38
21639951-19494296-4289467 18465-18467 19494296 denotes 38
21639951-20185725-4289468 18729-18731 20185725 denotes 42
21639951-18239685-4289469 18906-18908 18239685 denotes 43
21639951-18212736-4289469 18906-18908 18212736 denotes 43
21639951-17703191-4289469 18906-18908 17703191 denotes 43
21639951-11009421-4289469 18906-18908 11009421 denotes 43
21639951-11009421-4289470 19306-19308 11009421 denotes 46
21639951-20530205-4289471 19744-19746 20530205 denotes 47
21639951-20705491-4289472 19921-19923 20705491 denotes 48
21639951-21088135-4289473 19924-19926 21088135 denotes 49
21639951-1381359-4289474 20151-20153 1381359 denotes 50
21639951-20506221-4289475 20848-20850 20506221 denotes 51
21639951-19643665-4289476 21723-21725 19643665 denotes 52
21639951-19643665-4289477 21887-21889 19643665 denotes 52
21639951-20822710-4289478 22608-22610 20822710 denotes 53
21639951-18239685-4289479 23273-23275 18239685 denotes 43
21639951-18212736-4289480 23276-23278 18212736 denotes 44
21639951-19464428-4289481 23470-23472 19464428 denotes 54
21639951-16633345-4289482 23688-23690 16633345 denotes 55
21639951-19060883-4289483 23691-23693 19060883 denotes 56
21639951-17088249-4289484 23836-23838 17088249 denotes 57
21639951-16025521-4289485 23906-23908 16025521 denotes 58
21639951-19060883-4289486 24000-24002 19060883 denotes 56
21639951-12965196-4289487 24328-24330 12965196 denotes 59
21639951-20362473-4289488 24659-24661 20362473 denotes 60
21639951-19169254-4289489 24780-24782 19169254 denotes 61
21639951-19838195-4289490 24783-24785 19838195 denotes 62
21639951-10835629-4289491 25380-25382 10835629 denotes 63
21639951-19373246-4289492 25572-25574 19373246 denotes 64
21639951-19373246-4289493 25725-25727 19373246 denotes 64
21639951-19373246-4289494 26270-26272 19373246 denotes 64
21639951-18382763-4289495 26381-26383 18382763 denotes 65
21639951-18382763-4289496 26841-26843 18382763 denotes 65
21639951-17187080-4289497 27073-27075 17187080 denotes 66
21639951-12925853-4289498 27673-27675 12925853 denotes 67
21639951-19835640-4289499 27786-27788 19835640 denotes 68
21639951-14715412-4289500 28001-28003 14715412 denotes 69
21639951-20506350-4289501 28004-28006 20506350 denotes 70
21639951-20506350-4289502 28348-28350 20506350 denotes 70
21639951-16622006-4289503 29007-29009 16622006 denotes 71
21639951-11672546-4289504 29010-29012 11672546 denotes 72
21639951-8692885-4289505 29771-29773 8692885 denotes 73
21639951-17804836-4289506 30021-30023 17804836 denotes 74
21639951-18648537-4289507 30105-30107 18648537 denotes 75
21639951-19714643-4289508 30212-30214 19714643 denotes 76
21639951-20098459-4289509 30570-30572 20098459 denotes 77
21639951-16885212-4289510 30750-30752 16885212 denotes 78
21639951-17242365-4289511 30753-30755 17242365 denotes 79
21639951-16885212-4289512 30904-30906 16885212 denotes 78
21639951-17242365-4289513 31021-31023 17242365 denotes 79
21639951-17911593-4289514 31024-31026 17911593 denotes 80
21639951-18383392-4289515 31142-31144 18383392 denotes 81
21639951-18438844-4289516 31145-31147 18438844 denotes 82
21639951-18759964-4289517 31215-31217 18759964 denotes 83
21639951-20459811-4289518 31305-31307 20459811 denotes 84
21639951-20870441-4289519 31445-31447 20870441 denotes 86
21639951-18383392-4289520 31636-31638 18383392 denotes 81
21639951-17463289-4289521 31737-31739 17463289 denotes 87
21639951-20470394-4289522 32053-32055 20470394 denotes 88
21639951-19404929-4289523 32465-32467 19404929 denotes 89
21639951-21279994-4289524 32624-32626 21279994 denotes 90
21639951-18759964-4289525 32799-32801 18759964 denotes 83
21639951-20470394-4289526 32802-32804 20470394 denotes 88
21639951-19931339-4289527 32805-32807 19931339 denotes 91

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T5 0-8 JJ denotes Negative
T6 9-19 NN denotes regulation
T7 20-22 IN denotes of
T8 23-28 NN denotes NF-κB
T9 29-32 CC denotes and
T10 33-36 PRP-DOLLAR- denotes its
T11 37-48 NN denotes involvement
T12 49-51 IN denotes in
T13 52-62 JJ denotes rheumatoid
T14 63-72 NN denotes arthritis
T775 3046-3047 CD denotes 8
T21741 15159-15165 NN denotes factor
T21740 15150-15158 NN denotes necrosis
T21739 15143-15149 NN denotes tumour
T21738 15141-15142 -COMMA- denotes ,
T21737 15138-15141 NN denotes TNF
T21736 15136-15137 -COLON- denotes ;
T21735 15130-15136 NN denotes factor
T21734 15110-15129 JJ denotes receptor-associated
T21733 15106-15109 NN denotes TNF
T21732 15104-15105 -COMMA- denotes ,
T21731 15100-15104 NN denotes TRAF
T21730 15098-15099 -COLON- denotes ;
T21729 15093-15098 NN denotes NF-κB
T21728 15090-15092 IN denotes of
T21727 15080-15089 NN denotes activator
T21726 15071-15079 NN denotes receptor
T21725 15069-15070 -COMMA- denotes ,
T21724 15065-15069 NN denotes RANK
T21723 15063-15064 -COLON- denotes ;
T21722 15057-15063 NN denotes factor
T21721 15049-15056 JJ denotes nuclear
T21720 15047-15048 -COMMA- denotes ,
T21719 15045-15047 NN denotes NF
T21718 15043-15044 -COLON- denotes ;
T21717 15037-15043 NN denotes kinase
T21716 15033-15036 NN denotes IκB
T21715 15031-15032 -COMMA- denotes ,
T21714 15028-15031 NN denotes IKK
T21713 15026-15027 -COLON- denotes ;
T21712 15017-15026 NN denotes apoptosis
T21711 15014-15016 IN denotes of
T21710 15004-15013 NN denotes inhibitor
T21709 14995-15003 JJ denotes cellular
T21708 14993-14994 -COMMA- denotes ,
T21707 14989-14993 NN denotes cIAP
T21706 14980-14988 NN denotes factors.
T21705 14960-14979 JJ denotes receptor-associated
T21704 14956-14959 NN denotes TNF
T21703 14950-14955 JJ denotes other
T21702 14945-14949 IN denotes with
T21701 14935-14944 VB denotes competing
T21700 14932-14934 IN denotes by
T21699 14923-14931 RB denotes probably
T21698 14918-14922 RB denotes most
T21697 14916-14917 -COMMA- denotes ,
T21696 14909-14916 NN denotes pathway
T21695 14904-14908 DT denotes this
T21694 14901-14903 IN denotes of
T21693 14891-14900 NN denotes regulator
T21692 14882-14890 JJ denotes negative
T21691 14880-14881 DT denotes a
T21690 14877-14879 IN denotes as
T21689 14866-14876 VB denotes identified
T21688 14861-14865 VB denotes been
T21687 14856-14860 RB denotes also
T21686 14852-14855 VB denotes has
T21685 14846-14851 NN denotes TRAF1
T21684 14844-14845 -COMMA- denotes ,
T21683 14839-14844 NN denotes TRAF3
T21682 14836-14838 TO denotes to
T21681 14831-14835 JJ denotes Next
T21680 14816-14829 NN denotes transcription
T21679 14807-14815 VB denotes activate
T21678 14804-14806 TO denotes to
T21677 14799-14803 NN denotes RelB
T21676 14794-14798 IN denotes with
T21675 14782-14793 NN denotes heterodimer
T21674 14780-14781 DT denotes a
T21673 14774-14779 VB denotes forms
T21672 14768-14773 WDT denotes which
T21671 14766-14767 -COMMA- denotes ,
T21670 14763-14766 NN denotes p52
T21669 14760-14762 TO denotes to
T21668 14755-14759 NN denotes p100
T21667 14752-14754 IN denotes of
T21666 14740-14751 NN denotes degradation
T21665 14728-14739 JJ denotes proteasomal
T21664 14720-14727 JJ denotes partial
T21663 14716-14719 CC denotes and
T21662 14697-14715 NN denotes polyubiquitination
T21661 14686-14696 JJ denotes K48-linked
T21660 14683-14685 IN denotes by
T21659 14674-14682 VB denotes followed
T21658 14671-14673 VB denotes is
T21657 14666-14670 DT denotes This
T21656 14649-14664 NN denotes phosphorylation
T21655 14644-14648 NN denotes p100
T21654 14638-14643 NN denotes NF-κB
T21653 14629-14637 VB denotes mediates
T21652 14623-14628 WDT denotes which
T21651 14621-14622 -COMMA- denotes ,
T21650 14617-14621 NN denotes IKK1
T21649 14607-14616 VB denotes activates
T21648 14603-14606 CC denotes and
T21647 14588-14602 VB denotes phosphorylates
T21646 14583-14587 RB denotes then
T21645 14579-14582 NN denotes NIK
T21644 14573-14577 NN denotes cell
T21643 14569-14572 DT denotes the
T21642 14566-14568 IN denotes in
T21641 14559-14565 NN denotes levels
T21640 14555-14558 NN denotes NIK
T21639 14545-14554 VB denotes increased
T21638 14542-14544 IN denotes in
T21637 14532-14541 VB denotes resulting
T21636 14530-14531 -COMMA- denotes ,
T21635 14520-14530 VB denotes stabilised
T21634 14517-14519 VB denotes is
T21633 14513-14516 NN denotes NIK
T21632 14509-14512 CC denotes and
T21631 14500-14508 VB denotes degraded
T21630 14497-14499 VB denotes is
T21629 14491-14496 NN denotes TRAF3
T21628 14489-14490 -COMMA- denotes ,
T21627 14483-14489 NN denotes result
T21626 14481-14482 DT denotes a
T21625 14478-14480 IN denotes As
T21624 14473-14476 NN denotes NIK
T21623 14468-14472 IN denotes than
T21622 14461-14467 RB denotes rather
T21621 14459-14460 -COMMA- denotes ,
T21620 14454-14459 NN denotes TRAF3
T21619 14451-14453 TO denotes to
T21618 14432-14450 NN denotes polyubiquitination
T21617 14421-14431 JJ denotes K48-linked
T21616 14417-14420 PRP-DOLLAR- denotes its
T21615 14409-14416 VB denotes directs
T21614 14401-14408 NN denotes cIAP1/2
T21613 14388-14400 RB denotes Subsequently
T21612 14376-14386 NN denotes activation
T21611 14370-14375 PRP-DOLLAR- denotes their
T21610 14367-14369 IN denotes in
T21594 14250-14252 VB denotes is
T21593 14244-14249 NN denotes TRAF3
T21592 14242-14243 -COMMA- denotes ,
T21591 14235-14242 NN denotes binding
T21590 14228-14234 NN denotes ligand
T21589 14223-14227 IN denotes Upon
T21588 14218-14221 JJ denotes low
T21587 14211-14217 NN denotes levels
T21586 14207-14210 NN denotes NIK
T21585 14199-14206 VB denotes keeping
T21584 14197-14198 -COMMA- denotes ,
T21583 14194-14197 NN denotes NIK
T21582 14191-14193 IN denotes of
T21581 14179-14190 NN denotes degradation
T21580 14167-14178 JJ denotes proteasomal
T21579 14163-14166 CC denotes and
T21578 14144-14162 NN denotes polyubiquitination
T21577 14133-14143 JJ denotes K48-linked
T21576 14129-14132 DT denotes the
T21575 14117-14128 VB denotes facilitates
T21574 14111-14116 WDT denotes which
T21573 14109-14110 -COMMA- denotes ,
T21572 14102-14109 NN denotes cIAP1/2
T21571 14098-14101 CC denotes and
T21570 14092-14097 NN denotes TRAF3
T21569 14090-14091 -COMMA- denotes ,
T21568 14085-14090 NN denotes TRAF2
T21567 14077-14084 NN denotes ligases
T21566 14067-14076 NN denotes ubiquitin
T21565 14063-14066 DT denotes the
T21564 14058-14062 IN denotes with
T21563 14050-14057 NN denotes complex
T21562 14040-14049 JJ denotes cytosolic
T21561 14038-14039 DT denotes a
T21560 14032-14037 VB denotes forms
T21559 14028-14031 NN denotes NIK
T21558 14022-14027 NN denotes cells
T21557 14009-14021 JJ denotes unstimulated
T21556 14006-14008 IN denotes In
T21555 13998-14004 NN denotes levels
T21554 13987-13997 NN denotes expression
T21553 13985-13986 -RRB- denotes )
T21552 13982-13985 NN denotes NIK
T21551 13981-13982 -LRB- denotes (
T21550 13974-13980 NN denotes kinase
T21549 13965-13973 VB denotes inducing
T21548 13959-13964 NN denotes NF-κB
T21547 13956-13958 IN denotes on
T21546 13946-13955 JJ denotes dependent
T21545 13943-13945 VB denotes is
T21544 13938-13942 WDT denotes that
T21543 13930-13937 NN denotes pathway
T21542 13924-13929 NN denotes NF-κB
T21541 13911-13923 JJ denotes noncanonical
T21540 13907-13910 DT denotes the
T21539 13898-13906 VB denotes activate
T21538 13894-13897 MD denotes can
T21537 13889-13893 NN denotes RANK
T21536 13885-13888 CC denotes and
T21535 13880-13884 NN denotes CD40
T21534 13868-13878 NN denotes signalling
T21533 13862-13867 NN denotes NF-κB
T21532 13849-13861 JJ denotes Noncanonical
T21605 14326-14344 NN denotes polyubiquitination
T21604 14315-14325 JJ denotes K63-linked
T21603 14300-14314 JJ denotes nondegradative
T21602 14292-14299 VB denotes directs
T21601 14286-14291 NN denotes TRAF2
T21600 14280-14285 WRB denotes where
T21599 14278-14279 -COMMA- denotes ,
T21598 14270-14278 NN denotes receptor
T21597 14266-14269 DT denotes the
T21596 14263-14265 TO denotes to
T21595 14253-14262 VB denotes recruited
T21609 14357-14366 VB denotes resulting
T21608 14355-14356 -COMMA- denotes ,
T21607 14348-14355 NN denotes cIAP1/2
T21606 14345-14347 IN denotes of
T20005 10717-10723 NN denotes factor
T20004 10708-10716 NN denotes necrosis
T20003 10701-10707 NN denotes tumour
T20002 10699-10700 -COMMA- denotes ,
T20001 10696-10699 NN denotes TNF
T20000 10694-10695 -COLON- denotes ;
T19999 10686-10694 NN denotes receptor
T19998 10676-10685 JJ denotes Toll-like
T19997 10674-10675 -COMMA- denotes ,
T19996 10671-10674 NN denotes TLR
T19995 10669-10670 -COLON- denotes ;
T19994 10663-10669 NN denotes factor
T19993 10643-10662 JJ denotes receptor-associated
T19992 10639-10642 NN denotes TNF
T19991 10637-10638 -COMMA- denotes ,
T19990 10633-10637 NN denotes TRAF
T19989 10631-10632 -COLON- denotes ;
T19988 10617-10631 NN denotes receptor/IL-1R
T19987 10607-10616 JJ denotes Toll-like
T19986 10605-10606 -COMMA- denotes ,
T19985 10602-10605 NN denotes TIR
T19984 10600-10601 -COLON- denotes ;
T19983 10584-10600 JJ denotes receptor-related
T19982 10558-10583 NN denotes single-immunoglobulinIL-1
T19981 10556-10557 -COMMA- denotes ,
T19980 10550-10556 NN denotes SIGIRR
T19979 10548-10549 -COLON- denotes ;
T19978 10547-10548 CD denotes 1
T19977 10539-10546 NN denotes protein
T19976 10527-10538 VB denotes interacting
T19975 10518-10526 NN denotes receptor
T19974 10516-10517 -COMMA- denotes ,
T19973 10512-10516 NN denotes RIP1
T19972 10510-10511 -COLON- denotes ;
T19971 10505-10510 NN denotes NF-κB
T19970 10502-10504 IN denotes of
T19969 10492-10501 NN denotes activator
T19968 10483-10491 NN denotes receptor
T19967 10481-10482 -COMMA- denotes ,
T19966 10477-10481 NN denotes RANK
T19965 10475-10476 -COLON- denotes ;
T19964 10469-10475 NN denotes factor
T19963 10461-10468 JJ denotes nuclear
T19962 10459-10460 -COMMA- denotes ,
T19961 10457-10459 NN denotes NF
T19960 10455-10456 -COLON- denotes ;
T19959 10446-10455 NN denotes modulator
T19958 10436-10445 JJ denotes essential
T19957 10430-10435 NN denotes NF-κB
T19956 10428-10429 -COMMA- denotes ,
T19955 10424-10428 NN denotes NEMO
T19954 10422-10423 -COLON- denotes ;
T19953 10420-10422 CD denotes 88
T19952 10415-10419 NN denotes gene
T19951 10406-10414 NN denotes response
T19950 10398-10405 JJ denotes primary
T19949 10382-10397 NN denotes differentiation
T19948 10374-10381 JJ denotes myeloid
T19947 10372-10373 -COMMA- denotes ,
T19946 10367-10372 NN denotes MyD88
T19945 10365-10366 -COLON- denotes ;
T19944 10359-10365 NN denotes kinase
T19943 10342-10358 JJ denotes IL-1R-associated
T19942 10340-10341 -COMMA- denotes ,
T19941 10336-10340 NN denotes IRAK
T19940 10334-10335 -COLON- denotes ;
T19939 10329-10334 NN denotes NF-κB
T19938 10326-10328 IN denotes of
T19937 10316-10325 NN denotes inhibitor
T19936 10314-10315 -COMMA- denotes ,
T19935 10311-10314 NN denotes IκB
T19934 10309-10310 -COLON- denotes ;
T19933 10303-10309 NN denotes kinase
T19932 10299-10302 NN denotes IκB
T19931 10297-10298 -COMMA- denotes ,
T19930 10294-10297 NN denotes IKK
T19929 10292-10293 -COLON- denotes ;
T19928 10277-10292 NN denotes cylindromatosis
T19927 10275-10276 -COMMA- denotes ,
T19926 10271-10275 NN denotes CYLD
T19925 10269-10270 -COLON- denotes ;
T19924 10260-10269 NN denotes apoptosis
T19923 10257-10259 IN denotes of
T19922 10247-10256 NN denotes inhibitor
T19921 10238-10246 JJ denotes cellular
T19920 10236-10237 -COMMA- denotes ,
T19919 10232-10236 NN denotes cIAP
T19918 10230-10231 -COLON- denotes ;
T19917 10225-10230 NN denotes NF-κB
T19916 10222-10224 IN denotes of
T19915 10212-10221 NN denotes inhibitor
T19914 10200-10211 JJ denotes A20-binding
T19913 10198-10199 -COMMA- denotes ,
T19912 10194-10198 NN denotes ABIN
T19911 10182-10192 NN denotes activation
T19910 10176-10181 NN denotes NF-κB
T19909 10173-10175 IN denotes of
T19908 10162-10172 NN denotes regulation
T19907 10153-10161 NN denotes feedback
T19906 10144-10152 JJ denotes negative
T19905 10140-10143 DT denotes the
T19904 10137-10139 IN denotes in
T19903 10132-10136 PRP denotes them
T19902 10120-10131 VB denotes implicating
T19901 10118-10119 -COMMA- denotes ,
T19900 10109-10118 JJ denotes dependent
T19899 10103-10108 NN denotes NF-κB
T19898 10100-10102 VB denotes is
T19897 10090-10099 NN denotes molecules
T19896 10079-10089 JJ denotes regulatory
T19895 10070-10078 JJ denotes negative
T19894 10064-10069 DT denotes these
T19893 10061-10063 IN denotes of
T19892 10056-10060 JJ denotes many
T19891 10053-10055 IN denotes of
T19890 10042-10052 NN denotes expression
T19889 10038-10041 DT denotes The
T19888 10031-10036 NN denotes TRAF6
T19887 10027-10030 CC denotes and
T19886 10021-10026 NN denotes IRAK1
T19885 10018-10020 TO denotes to
T19884 10010-10017 VB denotes binding
T19883 10006-10009 IN denotes for
T19882 10001-10005 NN denotes TLR4
T19881 9996-10000 IN denotes with
T19880 9988-9995 VB denotes compete
T19879 9985-9987 TO denotes to
T19878 9976-9984 VB denotes proposed
T19877 9971-9975 VB denotes been
T19876 9967-9970 VB denotes has
T19875 9961-9966 WDT denotes which
T19874 9959-9960 -COMMA- denotes ,
T19873 9953-9959 NN denotes SIGIRR
T19872 9945-9952 NN denotes protein
T19871 9931-9944 JJ denotes transmembrane
T19870 9927-9930 DT denotes the
T19869 9924-9926 IN denotes by
T19868 9914-9923 VB denotes inhibited
T19867 9911-9913 VB denotes be
T19866 9906-9910 RB denotes also
T19865 9902-9905 MD denotes can
T19864 9891-9901 NN denotes signalling
T19863 9887-9890 NN denotes TLR
T19862 9885-9886 -COMMA- denotes ,
T19861 9878-9885 RB denotes Finally
T19860 9871-9876 NN denotes TRAF6
T19859 9867-9870 CC denotes and
T19858 9861-9866 NN denotes IRAK1
T19857 9858-9860 IN denotes of
T19856 9847-9857 NN denotes expression
T19855 9836-9846 VB denotes inhibiting
T19854 9833-9835 IN denotes by
T19853 9822-9832 NN denotes signalling
T19852 9818-9821 NN denotes TLR
T19851 9809-9817 VB denotes regulate
T19850 9798-9808 RB denotes negatively
T19849 9795-9797 TO denotes to
T19848 9787-9794 VB denotes thought
T19847 9784-9786 VB denotes is
T19846 9776-9783 NN denotes miR-146
T19845 9771-9775 NN denotes p62.
T19844 9767-9770 CC denotes and
T19843 9760-9766 NN denotes ABIN-1
T19842 9757-9759 IN denotes as
T19841 9752-9756 JJ denotes such
T19840 9743-9751 NN denotes proteins
T19839 9735-9742 NN denotes adaptor
T19838 9717-9734 JJ denotes ubiquitin-binding
T19837 9708-9716 JJ denotes specific
T19836 9702-9707 VB denotes using
T19835 9692-9701 VB denotes recruited
T19834 9688-9691 VB denotes are
T19833 9683-9687 PRP denotes they
T19832 9677-9682 WDT denotes which
T19831 9674-9676 TO denotes to
T19830 9672-9673 -COMMA- denotes ,
T19829 9667-9672 NN denotes TRAF6
T19828 9663-9666 CC denotes and
T19827 9658-9662 NN denotes RIP1
T19826 9648-9657 VB denotes including
T19825 9639-9647 NN denotes proteins
T19824 9628-9638 NN denotes signalling
T19823 9619-9627 JJ denotes specific
T19822 9609-9618 VB denotes targeting
T19821 9606-9608 IN denotes by
T19820 9595-9605 NN denotes activation
T19819 9589-9594 NN denotes NF-κB
T19783 9356-9363 NN denotes nucleus
T19782 9352-9355 DT denotes the
T19781 9349-9351 TO denotes to
T19780 9337-9348 VB denotes translocate
T19779 9334-9336 TO denotes to
T19778 9332-9333 -RRB- denotes )
T19777 9329-9332 NN denotes p50
T19776 9325-9328 CC denotes and
T19775 9321-9324 NN denotes p65
T19774 9318-9320 IN denotes of
T19773 9306-9317 NN denotes heterodimer
T19772 9304-9305 DT denotes a
T19771 9301-9303 IN denotes as
T19770 9295-9300 VB denotes shown
T19769 9290-9294 RB denotes here
T19768 9289-9290 -LRB- denotes (
T19767 9283-9288 NN denotes NF-κB
T19766 9276-9282 VB denotes allows
T19765 9271-9275 DT denotes This
T19764 9258-9269 NN denotes degradation
T19763 9246-9257 JJ denotes proteasomal
T19762 9242-9245 CC denotes and
T19761 9227-9241 NN denotes ubiquitination
T19760 9216-9226 JJ denotes K48-linked
T19759 9212-9215 PRP-DOLLAR- denotes its
T19758 9201-9211 VB denotes triggering
T19757 9199-9200 -COMMA- denotes ,
T19756 9195-9199 NN denotes IκBα
T19755 9180-9194 VB denotes phosphorylates
T19754 9175-9179 NN denotes turn
T19753 9172-9174 IN denotes in
T19752 9166-9171 WDT denotes which
T19751 9164-9165 -COMMA- denotes ,
T19750 9160-9164 NN denotes IKK2
T19749 9150-9159 VB denotes activates
T19748 9146-9149 CC denotes and
T19747 9131-9145 VB denotes phosphorylates
T19746 9126-9130 RB denotes then
T19745 9121-9125 NN denotes TAK1
T19744 9115-9119 NN denotes TAK1
T19743 9111-9114 CC denotes and
T19742 9106-9110 NN denotes IKK2
T19741 9093-9105 RB denotes respectively
T19740 9090-9092 IN denotes of
T19739 9079-9089 NN denotes activation
T19738 9075-9078 CC denotes and
T19737 9063-9074 NN denotes recruitment
T19736 9059-9062 DT denotes the
T19735 9056-9058 IN denotes in
T19734 9046-9055 VB denotes resulting
T19733 9044-9045 -COMMA- denotes ,
T19732 9036-9044 NN denotes proteins
T19731 9032-9035 NN denotes TAB
T19730 9028-9031 CC denotes and
T19729 9023-9027 NN denotes NEMO
T19728 9020-9022 IN denotes by
T19727 9009-9019 VB denotes recognised
T19726 9006-9008 VB denotes is
T19725 9004-9005 -COMMA- denotes ,
T19724 8999-9004 NN denotes IRAK1
T19723 8995-8998 CC denotes and
T19722 8990-8994 NN denotes RIP1
T19721 8988-8989 -COMMA- denotes ,
T19720 8983-8988 NN denotes TRAFs
T19719 8980-8982 IN denotes of
T19718 8961-8979 NN denotes polyubiquitination
T19717 8950-8960 JJ denotes K63-linked
T19716 8940-8948 NN denotes receptor
T19715 8936-8939 DT denotes the
T19714 8933-8935 TO denotes to
T19713 8931-8932 -RRB- denotes )
T19712 8926-8931 NN denotes cIAP2
T19711 8924-8925 -COMMA- denotes ,
T19710 8919-8924 NN denotes cIAP1
T19709 8917-8918 -COMMA- denotes ,
T19708 8912-8917 NN denotes TRAF6
T19707 8910-8911 -COMMA- denotes ,
T19706 8905-8910 NN denotes TRAF2
T19705 8904-8905 -LRB- denotes (
T19704 8896-8903 NN denotes ligases
T19703 8886-8895 NN denotes ubiquitin
T19702 8882-8885 CC denotes and
T19701 8880-8881 -COMMA- denotes ,
T19700 8879-8880 -RRB- denotes )
T19699 8874-8879 NN denotes IRAK4
T19698 8872-8873 -COMMA- denotes ,
T19697 8867-8872 NN denotes IRAK1
T19696 8865-8866 -COMMA- denotes ,
T19695 8861-8865 NN denotes RIP1
T19694 8860-8861 -LRB- denotes (
T19693 8852-8859 NN denotes kinases
T19692 8850-8851 -COMMA- denotes ,
T19691 8849-8850 -RRB- denotes )
T19690 8848-8849 -RRB- denotes )
T19689 8844-8848 NN denotes TRIF
T19688 8843-8844 -LRB- denotes (
T19687 8838-8842 NN denotes IFNβ
T19686 8821-8837 JJ denotes adaptor-inducing
T19685 8803-8820 JJ denotes domain-containing
T19684 8799-8802 NN denotes TIR
T19683 8797-8798 -COMMA- denotes ,
T19682 8794-8797 NNP denotes MAL
T19681 8792-8793 -COMMA- denotes ,
T19680 8787-8792 NN denotes MyD88
T19679 8785-8786 -COMMA- denotes ,
T19678 8784-8785 -RRB- denotes )
T19677 8779-8784 NN denotes TRADD
T19676 8778-8779 -LRB- denotes (
T19675 8770-8777 NN denotes protein
T19674 8763-8769 NN denotes domain
T19673 8757-8762 NN denotes death
T19672 8744-8756 JJ denotes 1-associated
T19671 8735-8743 NN denotes receptor
T19670 8731-8734 NN denotes TNF
T19669 8730-8731 -LRB- denotes (
T19668 8721-8729 NN denotes proteins
T19667 8713-8720 NN denotes adaptor
T19666 8704-8712 JJ denotes specific
T19665 8701-8703 IN denotes of
T19664 8689-8700 NN denotes recruitment
T19663 8685-8688 DT denotes the
T19662 8677-8684 VB denotes trigger
T19661 8672-8676 NN denotes TLR4
T19660 8668-8671 CC denotes and
T19659 8666-8667 -COMMA- denotes ,
T19658 8662-8666 NN denotes RANK
T19657 8660-8661 -COMMA- denotes ,
T19656 8656-8660 NN denotes CD40
T19655 8654-8655 -COMMA- denotes ,
T19654 8649-8654 NN denotes TNFR1
T19653 8646-8648 IN denotes as
T19652 8641-8645 JJ denotes such
T19651 8631-8640 NN denotes receptors
T19650 8622-8630 NN denotes membrane
T19649 8613-8621 JJ denotes specific
T19648 8610-8612 IN denotes of
T19647 8599-8609 NN denotes engagement
T19646 8592-8598 NN denotes Ligand
T19645 8580-8590 NN denotes regulators
T19644 8571-8579 JJ denotes negative
T19643 8567-8570 CC denotes and
T19642 8556-8566 NN denotes signalling
T19641 8550-8555 NN denotes NF-κB
T19640 8540-8549 JJ denotes Canonical
T19818 9581-9588 VB denotes control
T19817 9576-9580 WDT denotes that
T19816 9568-9575 NN denotes enzymes
T19815 9551-9567 VB denotes deubiquitinating
T19814 9547-9550 VB denotes are
T19813 9542-9546 NN denotes CYLD
T19812 9538-9541 CC denotes and
T19811 9534-9537 NN denotes A20
T19810 9527-9532 NN denotes TRAFs
T19809 9521-9526 JJ denotes other
T19808 9516-9520 IN denotes with
T19807 9506-9515 VB denotes competing
T19806 9503-9505 IN denotes by
T19805 9494-9502 RB denotes probably
T19804 9489-9493 RB denotes most
T19803 9487-9488 -COMMA- denotes ,
T19802 9477-9487 NN denotes activation
T19801 9471-9476 NN denotes NF-κB
T19800 9462-9470 VB denotes regulate
T19799 9451-9461 RB denotes negatively
T19798 9447-9450 MD denotes can
T19797 9445-9446 -COMMA- denotes ,
T19796 9437-9445 NN denotes activity
T19795 9430-9436 NN denotes ligase
T19794 9420-9429 NN denotes ubiquitin
T19793 9417-9419 DT denotes no
T19792 9413-9416 VB denotes has
T19791 9407-9412 WDT denotes which
T19790 9405-9406 -COMMA- denotes ,
T19789 9400-9405 NN denotes TRAF1
T19788 9388-9398 NN denotes expression
T19787 9383-9387 NN denotes gene
T19786 9376-9382 NN denotes target
T19785 9368-9375 VB denotes promote
T19784 9364-9367 CC denotes and
T19033 33618-33630 JJ denotes inflammatory
T19032 33614-33617 IN denotes for
T19031 33603-33613 NN denotes treatments
T19030 33599-33602 JJ denotes new
T19029 33596-33598 TO denotes to
T19028 33591-33595 VB denotes lead
T19027 33587-33590 MD denotes may
T19026 33577-33586 NN denotes knowledge
T19025 33572-33576 DT denotes this
T19024 33568-33571 WRB denotes how
T19023 33566-33567 -COMMA- denotes ,
T19022 33555-33566 RB denotes importantly
T19021 33550-33554 RB denotes more
T19020 33548-33549 -COMMA- denotes ,
T19019 33545-33548 CC denotes and
T19018 33543-33544 -COMMA- denotes ,
T19017 33534-33543 VB denotes organised
T19016 33531-33533 VB denotes is
T19015 33520-33530 NN denotes signalling
T19014 33514-33519 NN denotes NF-κB
T19013 33510-33513 WRB denotes how
T19012 33502-33509 VB denotes clarify
T19011 33499-33501 TO denotes to
T19010 33493-33498 NN denotes order
T19009 33490-33492 IN denotes in
T19008 33481-33489 NN denotes question
T19007 33471-33480 JJ denotes important
T19006 33468-33470 DT denotes an
T19005 33465-33467 VB denotes be
T19004 33460-33464 MD denotes will
T19003 33450-33459 VB denotes regulated
T19002 33439-33449 PRP denotes themselves
T19001 33435-33438 VB denotes are
T19000 33427-33434 NN denotes signals
T18999 33416-33426 JJ denotes regulatory
T18998 33410-33415 DT denotes these
T18997 33406-33409 PDT denotes all
T18996 33402-33405 WRB denotes How
T18995 33392-33400 VB denotes expected
T18994 33389-33391 VB denotes be
T18993 33385-33388 MD denotes can
T18992 33374-33384 NN denotes complexity
T18991 33366-33373 JJ denotes intense
T18990 33364-33365 -COMMA- denotes ,
T18989 33358-33364 VB denotes target
T18988 33353-33357 PRP denotes they
T18987 33347-33352 NN denotes mRNAs
T18986 33338-33346 JJ denotes multiple
T18985 33334-33337 DT denotes the
T18984 33330-33333 CC denotes and
T18983 33323-33329 NN denotes humans
T18982 33320-33322 IN denotes in
T18981 33313-33319 NN denotes miRNAs
T18980 33310-33312 IN denotes of
T18979 33303-33309 NN denotes number
T18978 33299-33302 DT denotes the
T18977 33293-33298 VB denotes given
T18976 33291-33292 -COMMA- denotes ,
T18975 33283-33291 NN denotes addition
T18974 33280-33282 IN denotes In
T18973 33274-33278 PRP denotes them
T18972 33266-33273 IN denotes between
T18971 33253-33265 NN denotes relationship
T18970 33249-33252 DT denotes the
T18969 33245-33248 CC denotes and
T18968 33234-33244 NN denotes regulators
T18967 33228-33233 DT denotes these
T18966 33225-33227 IN denotes of
T18965 33220-33224 DT denotes each
T18964 33217-33219 IN denotes of
T18963 33212-33216 NN denotes role
T18962 33203-33211 JJ denotes specific
T18961 33199-33202 DT denotes the
T18960 33196-33198 IN denotes of
T18959 33187-33195 NN denotes question
T18958 33183-33186 DT denotes the
T18957 33176-33182 VB denotes raises
T18956 33174-33175 -COMMA- denotes ,
T18955 33167-33174 RB denotes however
T18954 33165-33166 -COMMA- denotes ,
T18953 33158-33165 NN denotes pathway
T18952 33152-33157 NN denotes NF-κB
T18951 33148-33151 DT denotes the
T18950 33145-33147 IN denotes of
T18949 33134-33144 NN denotes regulation
T18948 33128-33133 JJ denotes tight
T18947 33126-33127 DT denotes a
T18946 33117-33125 VB denotes ensuring
T18945 33106-33116 NN denotes regulators
T18944 33097-33105 JJ denotes negative
T18943 33088-33096 JJ denotes multiple
T18942 33085-33087 IN denotes of
T18941 33075-33084 NN denotes existence
T18940 33071-33074 DT denotes The
T18939 33057-33069 NN denotes therapeutics
T18938 33048-33056 JJ denotes specific
T18937 33045-33047 IN denotes of
T18936 33038-33044 NN denotes design
T18935 33034-33037 DT denotes the
T18934 33030-33033 IN denotes for
T18933 33020-33029 JJ denotes important
T18932 33015-33019 RB denotes very
T18931 33012-33014 VB denotes be
T18930 33007-33011 RB denotes thus
T18929 33003-33006 MD denotes can
T18928 32995-33002 NN denotes control
T18927 32989-32994 IN denotes under
T18926 32978-32988 NN denotes activation
T18925 32972-32977 NN denotes NF-κB
T18924 32964-32971 VB denotes Keeping
T18923 32951-32962 NN denotes destruction
T18922 32946-32950 NN denotes bone
T18921 32942-32945 CC denotes and
T18920 32932-32941 NN denotes cartilage
T18919 32929-32931 TO denotes to
T18918 32921-32928 VB denotes leading
T18917 32918-32920 NN denotes RA
T18916 32915-32917 IN denotes in
T18915 32905-32914 NN denotes processes
T18914 32892-32904 JJ denotes inflammatory
T18913 32888-32891 DT denotes the
T18912 32885-32887 IN denotes in
T18911 32879-32884 NN denotes roles
T18910 32871-32878 JJ denotes crucial
T18909 32865-32870 VB denotes plays
T18908 32857-32864 NN denotes factors
T18907 32843-32856 NN denotes transcription
T18906 32840-32842 IN denotes of
T18905 32833-32839 NN denotes family
T18904 32827-32832 NN denotes NF-κB
T18903 32823-32826 DT denotes The
T17797 31717-31729 NN denotes pathogenesis
T17796 31713-31716 DT denotes the
T17795 31710-31712 IN denotes in
T17794 31702-31709 NN denotes process
T17793 31698-31701 JJ denotes key
T17792 31696-31697 DT denotes a
T17791 31694-31695 -COMMA- denotes ,
T17790 31684-31694 NN denotes production
T17789 31680-31683 NN denotes TNF
T17788 31672-31679 VB denotes promote
T17787 31669-31671 TO denotes to
T17786 31663-31668 VB denotes shown
T17785 31659-31662 VB denotes was
T17784 31651-31658 NN denotes miR-155
T17783 31649-31650 -COMMA- denotes ,
T17782 31641-31649 RB denotes Moreover
T17781 31613-31614 -RRB- denotes s
T17780 31611-31613 CD denotes is
T17779 31610-31611 -LRB- denotes t
T17778 31608-31610 NN denotes e
T17777 31606-31608 IN denotes at
T17776 31595-31606 NN denotes s that medi
T17775 31589-31595 NN denotes einase
T17774 31582-31589 VB denotes lloprot
T17773 31578-31582 WDT denotes meta
T17772 31559-31577 NN denotes of specific matrix
T17771 31553-31559 NN denotes ssion
T17770 31545-31553 JJ denotes le expre
T17769 31543-31545 IN denotes ib
T17768 31533-31543 NN denotes kine-induc
T17767 31515-31533 JJ denotes t the TLR and cyto
T17766 31512-31515 CC denotes ven
T17765 31509-31512 NN denotes pre
T17764 31506-31509 DT denotes to
T17763 31499-31506 VB denotes s able
T17762 31497-31499 TO denotes wa
T17761 31493-31497 JJ denotes sts
T17760 31490-31493 VB denotes bla
T17759 31479-31490 NN denotes ovial fibro
T17758 31471-31479 JJ denotes n in syn
T17757 31469-31471 IN denotes io
T17756 31455-31469 NN denotes 55 overexpress
T17755 31448-31455 NN denotes . miR-1
T17754 31447-31448 -RRB- denotes ]
T17753 31445-31447 CD denotes 86
T17752 31444-31445 -LRB- denotes [
T17751 31429-31443 NN denotes susceptibility
T17750 31426-31428 NN denotes RA
T17749 31421-31425 IN denotes with
T17748 31410-31420 VB denotes associated
T17747 31407-31409 VB denotes be
T17746 31404-31406 TO denotes to
T17745 31398-31403 VB denotes shown
T17744 31389-31397 RB denotes recently
T17743 31385-31388 VB denotes was
T17742 31380-31384 NN denotes gene
T17741 31373-31379 NN denotes target
T17740 31364-31372 NN denotes miR-146a
T17739 31360-31363 DT denotes the
T17738 31357-31359 IN denotes of
T17737 31350-31356 NN denotes 3'-UTR
T17736 31346-31349 DT denotes the
T17735 31343-31345 IN denotes in
T17734 31330-31342 NN denotes polymorphism
T17733 31328-31329 DT denotes a
T17732 31326-31327 -COMMA- denotes ,
T17731 31313-31326 RB denotes Interestingly
T17730 31298-31299 -RRB- denotes i
T17729 31293-31298 CD denotes A pat
T17728 31292-31293 -LRB- denotes R
T17727 31283-31291 NN denotes lls from
T17726 31281-31283 NN denotes ce
T17725 31276-31280 IN denotes ng T
T17724 31271-31276 NN denotes oduci
T17723 31270-31271 NN denotes r
T17722 31255-31270 JJ denotes D4+ and IL-17-p
T17721 31252-31255 CC denotes n C
T17720 31248-31252 JJ denotes ed i
T17719 31246-31248 IN denotes ss
T17718 31233-31246 VB denotes lso overexpre
T17717 31229-31233 RB denotes is a
T17716 31226-31228 VB denotes 6a
T17715 31218-31226 NN denotes . miR-14
T17714 31217-31218 -RRB- denotes ]
T17713 31215-31217 CD denotes 83
T17712 31214-31215 -LRB- denotes [
T17711 31205-31213 NN denotes patients
T17710 31202-31204 NN denotes RA
T17709 31199-31201 IN denotes of
T17708 31193-31198 NN denotes cells
T17707 31181-31192 JJ denotes mononuclear
T17706 31175-31180 NN denotes blood
T17705 31164-31174 JJ denotes peripheral
T17704 31161-31163 IN denotes in
T17703 31158-31160 IN denotes as
T17702 31153-31157 RB denotes well
T17701 31150-31152 RB denotes as
T17700 31148-31149 -COMMA- denotes ,
T17699 31147-31148 -RRB- denotes ]
T17698 31142-31147 CD denotes 81,82
T17697 31141-31142 -LRB- denotes [
T17696 31134-31140 NN denotes tissue
T17695 31125-31133 JJ denotes synovial
T17694 31121-31124 CC denotes and
T17693 31109-31120 NN denotes fibroblasts
T17692 31100-31108 JJ denotes synovial
T17691 31097-31099 NN denotes RA
T17690 31094-31096 IN denotes in
T17689 31087-31093 NN denotes levels
T17688 31080-31086 JJ denotes higher
T17687 31077-31079 IN denotes at
T17686 31067-31076 VB denotes expressed
T17685 31063-31066 VB denotes are
T17684 31055-31062 NN denotes miR-155
T17683 31051-31054 CC denotes and
T17682 31043-31050 NN denotes miR-146
T17681 31038-31042 CC denotes both
T17680 31036-31037 -COMMA- denotes ,
T17679 31029-31036 RB denotes Notably
T17678 31026-31027 -RRB- denotes ]
T17677 31021-31026 CD denotes 79,80
T17676 31020-31021 -LRB- denotes [
T17675 31015-31019 NN denotes RIP1
T17674 31011-31014 CC denotes and
T17673 31006-31010 NN denotes IKKε
T17672 30996-31005 NN denotes molecules
T17671 30985-30995 NN denotes signalling
T17670 30979-30984 NN denotes NF-κB
T17669 30975-30978 DT denotes the
T17668 30971-30974 IN denotes for
T17667 30959-30970 NN denotes transcripts
T17666 30952-30958 NN denotes target
T17665 30949-30951 TO denotes to
T17664 30943-30948 VB denotes shown
T17663 30939-30942 VB denotes was
T17662 30931-30938 NN denotes miR-155
T17661 30929-30930 -COMMA- denotes ,
T17660 30920-30929 RB denotes Similarly
T17659 30917-30918 -RRB- denotes )
T17658 30916-30917 CD denotes 1
T17657 30909-30915 NN denotes Figure
T17656 30908-30909 -LRB- denotes (
T17655 30906-30907 -RRB- denotes ]
T17654 30904-30906 CD denotes 78
T17653 30903-30904 -LRB- denotes [
T17652 30894-30902 NN denotes miR-146a
T17651 30891-30893 IN denotes of
T17650 30885-30890 NN denotes genes
T17649 30878-30884 NN denotes target
T17648 30875-30877 IN denotes as
T17647 30864-30874 VB denotes identified
T17646 30859-30863 VB denotes were
T17645 30853-30858 NN denotes TRAF6
T17644 30849-30852 CC denotes and
T17643 30843-30848 NN denotes IRAK1
T17642 30833-30842 NN denotes molecules
T17641 30822-30832 NN denotes signalling
T17640 30816-30821 NN denotes NF-κB
T17639 30812-30815 DT denotes the
T17638 30808-30811 CC denotes and
T17637 30806-30807 -COMMA- denotes ,
T17636 30802-30806 NN denotes gene
T17635 30786-30801 JJ denotes NF-κB-dependent
T17634 30783-30785 DT denotes an
T17633 30780-30782 VB denotes is
T17632 30771-30779 NN denotes miR-146a
T17631 30769-30770 -COMMA- denotes ,
T17630 30761-30769 NN denotes addition
T17629 30758-30760 IN denotes In
T17628 30755-30756 -RRB- denotes ]
T17627 30750-30755 CD denotes 78,79
T17626 30749-30750 -LRB- denotes [
T17625 30744-30748 NN denotes TLRs
T17624 30740-30743 CC denotes and
T17623 30736-30739 NN denotes TNF
T17622 30734-30735 -COMMA- denotes ,
T17621 30729-30734 NN denotes IL-1β
T17620 30726-30728 IN denotes as
T17619 30721-30725 JJ denotes such
T17618 30713-30720 NN denotes stimuli
T17617 30700-30712 JJ denotes inflammatory
T17616 30697-30699 IN denotes by
T17615 30689-30696 VB denotes induced
T17614 30686-30688 VB denotes be
T17613 30682-30685 MD denotes can
T17612 30675-30681 NN denotes miRNAs
T17611 30669-30674 DT denotes these
T17610 30663-30668 IN denotes since
T17609 30661-30662 -COMMA- denotes ,
T17608 30656-30661 NN denotes NF-κB
T17607 30653-30655 TO denotes to
T17606 30642-30652 NN denotes signalling
T17605 30629-30641 JJ denotes inflammatory
T17604 30625-30628 IN denotes for
T17603 30616-30624 NN denotes interest
T17602 30605-30615 JJ denotes particular
T17601 30602-30604 IN denotes of
T17600 30598-30601 VB denotes are
T17599 30590-30597 NN denotes miR-155
T17598 30586-30589 CC denotes and
T17597 30575-30585 NN denotes miR-146a/b
T17596 30572-30573 -RRB- denotes ]
T17595 30570-30572 CD denotes 77
T17594 30569-30570 -LRB- denotes [
T17593 30557-30568 NN denotes degradation
T17592 30552-30556 NN denotes mRNA
T17591 30545-30551 NN denotes target
T17590 30542-30544 IN denotes of
T17589 30532-30541 NN denotes promotion
T17588 30528-30531 DT denotes the
T17587 30524-30527 CC denotes and
T17586 30513-30523 NN denotes expression
T17585 30505-30512 NN denotes protein
T17584 30502-30504 IN denotes of
T17583 30491-30501 NN denotes repression
T17582 30487-30490 DT denotes the
T17979 32807-32808 -RRB- denotes ]
T17978 32799-32807 CD denotes 83,88,91
T17977 32798-32799 -LRB- denotes [
T17976 32785-32797 NN denotes pathogenesis
T17975 32781-32784 IN denotes for
T17974 32770-32780 NN denotes biomarkers
T17973 32759-32769 JJ denotes diagnostic
T17972 32756-32758 IN denotes as
T17971 32746-32755 NN denotes potential
T17970 32740-32745 PRP-DOLLAR- denotes their
T17969 32729-32739 VB denotes indicating
T17968 32727-32728 -COMMA- denotes ,
T17967 32719-32727 NN denotes patients
T17966 32716-32718 NN denotes RA
T17965 32713-32715 IN denotes in
T17964 32702-32712 NN denotes expression
T17963 32694-32701 VB denotes altered
T17962 32691-32693 DT denotes an
T17961 32686-32690 VB denotes have
T17960 32683-32685 TO denotes to
T17959 32677-32682 VB denotes shown
T17958 32672-32676 RB denotes also
T17957 32667-32671 VB denotes were
T17956 32659-32666 NN denotes miR-223
T17955 32655-32658 CC denotes and
T17954 32653-32654 -COMMA- denotes ,
T17953 32646-32653 NN denotes miR-132
T17952 32644-32645 -COMMA- denotes ,
T17951 32638-32644 NN denotes miR-16
T17950 32636-32637 -COMMA- denotes ,
T17949 32629-32636 RB denotes Finally
T17948 32626-32627 -RRB- denotes ]
T17947 32624-32626 CD denotes 90
T17946 32623-32624 -LRB- denotes [
T17945 32611-32622 NN denotes fibroblasts
T17944 32602-32610 JJ denotes synovial
T17943 32599-32601 NN denotes RA
T17942 32596-32598 IN denotes in
T17941 32587-32595 VB denotes detected
T17940 32582-32586 VB denotes were
T17939 32580-32581 -COLON- denotes -
T17938 32575-32579 NN denotes IL-6
T17937 32571-32574 CC denotes and
T17936 32551-32570 NN denotes metalloproteinase-1
T17935 32544-32550 NN denotes matrix
T17934 32541-32543 IN denotes of
T17933 32531-32540 NN denotes secretion
T17932 32521-32530 VB denotes increased
T17931 32518-32520 TO denotes to
T17930 32510-32517 VB denotes leading
T17929 32508-32509 -COLON- denotes -
T17928 32500-32507 NN denotes miR-203
T17927 32497-32499 IN denotes of
T17926 32490-32496 NN denotes levels
T17925 32481-32489 JJ denotes elevated
T17924 32479-32480 -COMMA- denotes ,
T17923 32470-32479 RB denotes Similarly
T17922 32467-32468 -RRB- denotes ]
T17921 32465-32467 CD denotes 89
T17920 32464-32465 -LRB- denotes [
T17919 32455-32463 NN denotes patients
T17918 32452-32454 NN denotes RA
T17917 32447-32451 IN denotes from
T17916 32434-32446 NN denotes synoviocytes
T17915 32431-32433 IN denotes in
T17914 32421-32430 VB denotes decreased
T17913 32418-32420 VB denotes be
T17912 32415-32417 TO denotes to
T17911 32409-32414 VB denotes shown
T17910 32405-32408 VB denotes was
T17909 32403-32404 -COLON- denotes -
T17908 32401-32402 CD denotes 1
T17907 32393-32400 NN denotes protein
T17906 32377-32392 NN denotes chemoattractant
T17905 32368-32376 NN denotes monocyte
T17904 32358-32367 NN denotes chemokine
T17903 32354-32357 DT denotes the
T17902 32351-32353 IN denotes of
T17901 32341-32350 NN denotes regulator
T17900 32337-32340 JJ denotes key
T17899 32335-32336 DT denotes a
T17898 32333-32334 -COLON- denotes -
T17897 32324-32332 NN denotes miR-124a
T17896 32322-32323 -COMMA- denotes ,
T17895 32315-32322 NN denotes context
T17894 32310-32314 DT denotes this
T17893 32307-32309 IN denotes In
T17892 32295-32305 VB denotes identified
T17891 32286-32294 RB denotes recently
T17890 32281-32285 VB denotes were
T17889 32271-32280 NN denotes pathology
T17888 32268-32270 NN denotes RA
T17887 32265-32267 IN denotes in
T17886 32255-32264 NN denotes responses
T17885 32242-32254 JJ denotes inflammatory
T17884 32226-32241 JJ denotes NF-κB-dependent
T17883 32223-32225 IN denotes of
T17882 32215-32222 NN denotes control
T17881 32211-32214 DT denotes the
T17880 32208-32210 IN denotes in
T17879 32203-32207 NN denotes role
T17878 32193-32202 JJ denotes potential
T17877 32191-32192 DT denotes a
T17876 32186-32190 IN denotes with
T17875 32179-32185 NN denotes miRNAs
T17874 32173-32178 JJ denotes other
T17873 32170-32172 IN denotes of
T17872 32163-32169 NN denotes number
T17871 32161-32162 DT denotes a
T17870 32159-32160 -COMMA- denotes ,
T17869 32152-32159 NN denotes miR-155
T17868 32148-32151 CC denotes and
T17867 32140-32147 NN denotes miR-146
T17866 32132-32139 IN denotes Besides
T17865 32124-32130 NN denotes cohort
T17864 32111-32123 JJ denotes well-defined
T17863 32107-32110 CC denotes and
T17862 32101-32106 JJ denotes large
T17861 32099-32100 DT denotes a
T17860 32093-32098 VB denotes using
T17859 32080-32092 NN denotes confirmation
T17858 32072-32079 VB denotes require
T17857 32067-32071 MD denotes will
T17856 32062-32066 DT denotes this
T17855 32058-32061 CC denotes but
T17854 32056-32057 -COMMA- denotes ,
T17853 32055-32056 -RRB- denotes ]
T17852 32053-32055 CD denotes 88
T17851 32052-32053 -LRB- denotes [
T17850 32043-32051 NN denotes efficacy
T17849 32033-32042 NN denotes treatment
T17848 32030-32032 CC denotes or
T17847 32028-32029 -COMMA- denotes ,
T17846 32017-32028 NN denotes progression
T17845 32015-32016 -COMMA- denotes ,
T17844 32006-32015 NN denotes diagnosis
T17843 31998-32005 NN denotes disease
T17842 31994-31997 IN denotes for
T17841 31987-31993 NN denotes marker
T17840 31985-31986 DT denotes a
T17839 31982-31984 IN denotes as
T17838 31975-31981 JJ denotes useful
T17837 31963-31974 RB denotes potentially
T17836 31960-31962 VB denotes is
T17835 31951-31959 NN denotes patients
T17834 31948-31950 NN denotes RA
T17833 31945-31947 IN denotes in
T17832 31934-31944 NN denotes expression
T17831 31924-31933 VB denotes increased
T17830 31918-31923 PRP-DOLLAR- denotes their
T17829 31916-31917 -COMMA- denotes ,
T17828 31908-31916 NN denotes addition
T17827 31905-31907 IN denotes In
T17826 31871-31882 JJ denotes of new trea
T17825 31869-31871 VB denotes t
T17824 31859-31869 NN denotes developmen
T17823 31855-31858 JJ denotes the
T17822 31852-31854 IN denotes or
T17821 31841-31852 NN denotes potential f
T17820 31838-31841 DT denotes ir
T17819 31835-31838 IN denotes the
T17818 31825-31834 NN denotes in RA and
T17817 31820-31825 PRP-DOLLAR- denotes tion
T17816 31817-31820 CC denotes mma
T17815 31815-31817 NN denotes la
T17814 31813-31815 IN denotes nf
T17813 31801-31813 NN denotes ulators of i
T17812 31799-31801 IN denotes eg
T17811 31789-31799 NN denotes negative r
T17810 31780-31788 JJ denotes mportant
T17809 31771-31780 JJ denotes fore be i
T17808 31769-31771 VB denotes re
T17807 31760-31769 RB denotes 5 may the
T17806 31757-31760 MD denotes -15
T17805 31750-31757 NN denotes and miR
T17804 31747-31750 CC denotes 46
T17803 31740-31747 NN denotes . miR-1
T17802 31739-31740 -RRB- denotes ]
T17801 31737-31739 CD denotes 87
T17800 31736-31737 -LRB- denotes [
T17799 31733-31735 NN denotes RA
T17798 31730-31732 IN denotes of
T17581 30484-30486 TO denotes to
T17580 30476-30483 VB denotes leading
T17579 30470-30475 NN denotes mRNAs
T17578 30463-30469 NN denotes target
T17577 30460-30462 IN denotes of
T17576 30453-30459 NN denotes 3'-UTR
T17575 30449-30452 DT denotes the
T17574 30444-30448 VB denotes bind
T17573 30439-30443 PRP denotes They
T17572 30425-30437 NN denotes inflammation
T17571 30421-30424 CC denotes and
T17570 30411-30420 NN denotes responses
T17569 30404-30410 JJ denotes immune
T17568 30394-30403 VB denotes including
T17567 30392-30393 -COMMA- denotes ,
T17566 30383-30392 NN denotes processes
T17565 30369-30382 JJ denotes developmental
T17564 30365-30368 CC denotes and
T17563 30356-30364 JJ denotes cellular
T17562 30351-30355 JJ denotes many
T17561 30348-30350 IN denotes in
T17560 30338-30347 JJ denotes essential
T17559 30328-30337 NN denotes molecules
T17558 30324-30327 NN denotes RNA
T17557 30314-30323 JJ denotes noncoding
T17556 30311-30313 IN denotes of
T17555 30305-30310 NN denotes class
T17554 30303-30304 DT denotes a
T17553 30293-30302 VB denotes represent
T17552 30289-30292 CC denotes and
T17551 30278-30288 NN denotes expression
T17550 30273-30277 NN denotes gene
T17549 30270-30272 IN denotes of
T17548 30259-30269 NN denotes regulators
T17547 30248-30258 VB denotes discovered
T17546 30239-30247 RB denotes recently
T17545 30235-30238 VB denotes are
T17544 30228-30234 NN denotes miRNAs
T17543 30218-30227 NN denotes microRNAs
T16673 30214-30215 -RRB- denotes ]
T16672 30212-30214 CD denotes 76
T16671 30211-30212 -LRB- denotes [
T16670 30208-30210 NN denotes RA
T16669 30203-30207 IN denotes with
T16668 30196-30202 NN denotes region
T16667 30190-30195 NN denotes TRAF1
T16666 30186-30189 DT denotes the
T16665 30183-30185 IN denotes of
T16664 30171-30182 NN denotes association
T16663 30163-30170 JJ denotes genetic
T16662 30150-30162 VB denotes demonstrates
T16661 30145-30149 RB denotes also
T16660 30134-30144 NN denotes population
T16659 30127-30133 JJ denotes Korean
T16658 30125-30126 DT denotes a
T16657 30122-30124 IN denotes in
T16656 30117-30121 NN denotes work
T16655 30110-30116 JJ denotes Recent
T16654 30107-30108 -RRB- denotes ]
T16653 30105-30107 CD denotes 75
T16652 30104-30105 -LRB- denotes [
T16651 30098-30103 NN denotes locus
T16650 30088-30097 JJ denotes causative
T16649 30084-30087 DT denotes the
T16648 30081-30083 VB denotes be
T16647 30078-30080 TO denotes to
T16646 30071-30077 JJ denotes likely
T16645 30066-30070 RB denotes more
T16644 30063-30065 VB denotes is
T16643 30057-30062 NN denotes TRAF1
T16625 29951-29954 DT denotes the
T16624 29948-29950 IN denotes at
T16623 29938-29947 NN denotes variation
T16622 29930-29937 JJ denotes genetic
T16621 29928-29929 DT denotes a
T16620 29917-29927 VB denotes identified
T16619 29908-29916 NN denotes controls
T16618 29902-29907 CD denotes 1,800
T16617 29898-29901 CC denotes and
T16616 29892-29897 NN denotes cases
T16615 29889-29891 NN denotes RA
T16614 29867-29888 JJ denotes autoantibody-positive
T16613 29861-29866 CD denotes 1,500
T16612 29847-29860 RB denotes approximately
T16611 29841-29846 IN denotes among
T16610 29836-29840 NN denotes SNPs
T16609 29828-29835 CD denotes 300,000
T16608 29823-29827 IN denotes than
T16607 29818-29822 JJ denotes more
T16606 29808-29817 VB denotes examining
T16605 29802-29807 NN denotes study
T16604 29790-29801 NN denotes association
T16603 29778-29789 JJ denotes genome-wide
T16602 29776-29777 DT denotes A
T16601 29773-29774 -RRB- denotes ]
T16600 29771-29773 CD denotes 73
T16599 29770-29771 -LRB- denotes [
T16598 29761-29769 VB denotes interact
T16597 29750-29760 RB denotes physically
T16596 29746-29749 MD denotes can
T16595 29743-29745 PRP denotes it
T16594 29737-29742 WDT denotes which
T16593 29732-29736 IN denotes with
T16592 29728-29731 NN denotes A20
T16591 29720-29727 VB denotes recruit
T16590 29714-29719 MD denotes might
T16589 29708-29713 NN denotes TRAF1
T16588 29706-29707 -COMMA- denotes ,
T16587 29693-29706 RB denotes Alternatively
T16586 29683-29691 NN denotes proteins
T16585 29672-29682 NN denotes signalling
T16584 29666-29671 JJ denotes other
T16583 29663-29665 CC denotes or
T16582 29654-29662 NN denotes receptor
T16581 29650-29653 DT denotes the
T16580 29647-29649 TO denotes to
T16579 29639-29646 VB denotes binding
T16578 29635-29638 IN denotes for
T16577 29627-29634 NN denotes members
T16576 29620-29626 NN denotes family
T16575 29615-29619 NN denotes TRAF
T16574 29610-29614 IN denotes with
T16573 29601-29609 VB denotes competes
T16572 29595-29600 NN denotes TRAF1
T16571 29593-29594 -COMMA- denotes ,
T16570 29585-29593 RB denotes probably
T16569 29580-29584 RB denotes Most
T16568 29571-29578 JJ denotes unclear
T16567 29565-29570 RB denotes still
T16566 29562-29564 VB denotes is
T16565 29551-29561 NN denotes activation
T16564 29548-29550 NN denotes κB
T16563 29544-29547 NF- denotes NF-
T16562 29534-29543 VB denotes modulates
T16561 29528-29533 NN denotes TRAF1
T16560 29522-29527 WDT denotes which
T16559 29519-29521 IN denotes by
T16558 29509-29518 NN denotes mechanism
T16557 29505-29508 DT denotes The
T16556 29498-29503 NN denotes cells
T16555 29492-29497 DT denotes these
T16554 29489-29491 IN denotes in
T16553 29484-29488 NN denotes role
T16552 29473-29483 JJ denotes regulatory
T16551 29464-29472 JJ denotes positive
T16550 29462-29463 DT denotes a
T16549 29451-29461 VB denotes suggesting
T16548 29449-29450 -COMMA- denotes ,
T16547 29442-29449 NN denotes factors
T16546 29426-29441 JJ denotes TRAF2-dependent
T16545 29423-29425 IN denotes by
T16544 29411-29422 NN denotes stimulation
T16543 29401-29410 JJ denotes secondary
T16542 29398-29400 TO denotes to
T16541 29388-29397 NN denotes responses
T16540 29377-29387 VB denotes attenuated
T16539 29372-29376 VB denotes show
T16538 29370-29371 -COMMA- denotes ,
T16537 29363-29370 RB denotes however
T16536 29361-29362 -COMMA- denotes ,
T16535 29356-29361 NN denotes cells
T16534 29346-29355 JJ denotes dendritic
T16533 29330-29345 JJ denotes TRAF1-deficient
T16532 29318-29328 NN denotes activation
T16531 29312-29317 NN denotes NF-κB
T16530 29299-29311 JJ denotes CD40-induced
T16529 29296-29298 IN denotes of
T16528 29286-29295 NN denotes regulator
T16527 29277-29285 JJ denotes negative
T16526 29275-29276 DT denotes a
T16525 29272-29274 IN denotes as
T16524 29262-29271 VB denotes functions
T16523 29257-29261 RB denotes also
T16522 29251-29256 NN denotes TRAF1
T16521 29242-29249 NN denotes pathway
T16520 29231-29241 NN denotes signalling
T16519 29225-29230 NN denotes NF-κB
T16518 29221-29224 DT denotes the
T16517 29218-29220 IN denotes of
T16516 29207-29217 NN denotes activation
T16515 29203-29206 CC denotes and
T16514 29189-29202 NN denotes proliferation
T16513 29180-29188 VB denotes enhanced
T16512 29175-29179 IN denotes with
T16511 29173-29174 -COMMA- denotes ,
T16510 29170-29173 NN denotes TNF
T16509 29167-29169 TO denotes to
T16508 29150-29166 JJ denotes hyper-responsive
T16507 29146-29149 VB denotes are
T16506 29140-29145 NN denotes cells
T16505 29138-29139 NN denotes T
T16504 29122-29137 JJ denotes TRAF1-deficient
T16503 29110-29120 NN denotes activation
T16502 29104-29109 NN denotes NF-κB
T16501 29092-29103 JJ denotes TNF-induced
T16500 29083-29091 VB denotes inhibits
T16499 29077-29082 NN denotes TRAF1
T16498 29074-29076 IN denotes of
T16497 29059-29073 NN denotes overexpression
T16496 29055-29058 CC denotes and
T16495 29051-29054 NN denotes TNF
T16494 29048-29050 IN denotes by
T16493 29038-29047 JJ denotes inducible
T16492 29035-29037 VB denotes is
T16491 29029-29034 NN denotes TRAF1
T16490 29026-29028 IN denotes of
T16489 29015-29025 NN denotes Expression
T16488 29012-29013 -RRB- denotes ]
T16487 29007-29012 CD denotes 71,72
T16486 29006-29007 -LRB- denotes [
T16485 28999-29005 NN denotes manner
T16484 28979-28998 JJ denotes cell-type-dependent
T16483 28977-28978 DT denotes a
T16482 28974-28976 IN denotes in
T16481 28965-28973 RB denotes possibly
T16480 28963-28964 -COMMA- denotes ,
T16479 28954-28963 NN denotes receptors
T16478 28947-28953 NN denotes family
T16477 28943-28946 NN denotes TNF
T16476 28935-28942 JJ denotes certain
T16475 28932-28934 IN denotes by
T16474 28921-28931 NN denotes signalling
T16473 28915-28920 NN denotes NF-κB
T16472 28912-28914 IN denotes of
T16471 28902-28911 NN denotes modulator
T16470 28893-28901 JJ denotes positive
T16469 28891-28892 DT denotes a
T16468 28887-28890 CC denotes and
T16467 28878-28886 JJ denotes negative
T16466 28876-28877 DT denotes a
T16465 28871-28875 CC denotes both
T16464 28868-28870 IN denotes as
T16463 28862-28867 NN denotes TRAF1
T16462 28858-28861 IN denotes for
T16461 28853-28857 NN denotes role
T16460 28851-28852 DT denotes a
T16459 28843-28850 VB denotes support
T16458 28838-28842 NN denotes data
T16457 28825-28837 VB denotes Accumulating
T16456 28815-28823 NN denotes activity
T16455 28808-28814 NN denotes ligase
T16454 28798-28807 NN denotes ubiquitin
T16453 28792-28797 VB denotes lacks
T16452 28782-28791 RB denotes therefore
T16451 28778-28781 CC denotes and
T16450 28771-28777 NN denotes domain
T16449 28764-28770 NN denotes finger
T16448 28759-28763 NN denotes RING
T16447 28757-28758 DT denotes a
T16446 28751-28756 VB denotes lacks
T16445 28748-28750 PRP denotes it
T16444 28740-28747 IN denotes because
T16443 28733-28739 NN denotes family
T16442 28725-28732 NN denotes protein
T16441 28720-28724 NN denotes TRAF
T16440 28716-28719 DT denotes the
T16439 28713-28715 IN denotes of
T16438 28706-28712 NN denotes member
T16437 28699-28705 JJ denotes unique
T16436 28697-28698 DT denotes a
T16435 28694-28696 VB denotes is
T16434 28688-28693 NN denotes TRAF1
T16433 28686-28687 CD denotes 1
T16432 28679-28685 NN denotes factor
T16431 28659-28678 JJ denotes receptor-associated
T16430 28655-28658 NN denotes TNF
T16642 30052-30056 IN denotes that
T16641 30042-30051 VB denotes indicates
T16640 30037-30041 NN denotes work
T16639 30026-30036 JJ denotes Subsequent
T16638 30023-30024 -RRB- denotes ]
T16637 30021-30023 CD denotes 74
T16636 30020-30021 -LRB- denotes [
T16635 30014-30019 NN denotes locus
T16634 30009-30013 NN denotes risk
T16633 30006-30008 NN denotes RA
T16632 29996-30005 JJ denotes important
T16631 29993-29995 DT denotes an
T16630 29990-29992 IN denotes as
T16629 29984-29989 NN denotes locus
T16628 29982-29983 CD denotes 5
T16627 29972-29981 NN denotes component
T16626 29955-29971 NN denotes TRAF1-complement
T15641 27883-27890 NN denotes pattern
T15640 27872-27882 NN denotes expression
T15639 27861-27871 JJ denotes restricted
T15638 27856-27860 RB denotes very
T15637 27854-27855 DT denotes a
T15636 27850-27853 VB denotes has
T15635 27843-27849 NN denotes SIGIRR
T15634 27833-27841 JJ denotes unlikely
T15633 27829-27832 RB denotes not
T15632 27826-27828 VB denotes is
T15631 27823-27825 NN denotes RA
T15630 27820-27822 IN denotes in
T15629 27813-27819 NN denotes SIGIRR
T15628 27809-27812 IN denotes for
T15627 27804-27808 NN denotes role
T15626 27793-27803 JJ denotes regulatory
T15625 27791-27792 DT denotes a
T15624 27789-27790 -COMMA- denotes ,
T15623 27788-27789 -RRB- denotes ]
T15622 27786-27788 CD denotes 68
T15621 27785-27786 -LRB- denotes [
T15620 27782-27784 NN denotes RA
T15619 27779-27781 IN denotes in
T15618 27770-27778 VB denotes observed
T15617 27757-27769 NN denotes inflammation
T15616 27749-27756 JJ denotes chronic
T15615 27745-27748 DT denotes the
T15614 27742-27744 IN denotes in
T15613 27731-27741 NN denotes signalling
T15612 27727-27730 NN denotes TLR
T15611 27723-27726 CC denotes and
T15610 27717-27722 NN denotes IL-1R
T15609 27714-27716 IN denotes of
T15608 27709-27713 NN denotes role
T15607 27699-27708 JJ denotes important
T15606 27695-27698 DT denotes the
T15605 27689-27694 VB denotes Given
T15604 27686-27687 -RRB- denotes )
T15603 27685-27686 CD denotes 1
T15602 27678-27684 NN denotes Figure
T15601 27677-27678 -LRB- denotes (
T15600 27675-27676 -RRB- denotes ]
T15599 27673-27675 CD denotes 67
T15598 27672-27673 -LRB- denotes [
T15597 27666-27671 NN denotes TRAF6
T15596 27663-27665 CC denotes or
T15595 27657-27662 NN denotes IRAK1
T15594 27655-27656 -COMMA- denotes ,
T15593 27650-27655 NN denotes MyD88
T15592 27648-27649 -COMMA- denotes ,
T15591 27639-27648 NN denotes receptors
T15590 27633-27638 DT denotes these
T15589 27628-27632 IN denotes with
T15588 27616-27627 NN denotes interaction
T15587 27609-27615 JJ denotes direct
T15586 27601-27608 IN denotes through
T15585 27592-27600 RB denotes probably
T15584 27590-27591 -COMMA- denotes ,
T15583 27580-27590 NN denotes signalling
T15582 27576-27579 NN denotes TLR
T15581 27572-27575 CC denotes and
T15580 27566-27571 NN denotes IL-1R
T15579 27563-27565 IN denotes of
T15578 27553-27562 NN denotes inhibitor
T15577 27550-27552 DT denotes an
T15576 27547-27549 IN denotes as
T15575 27533-27546 VB denotes characterised
T15574 27521-27532 RB denotes extensively
T15573 27516-27520 VB denotes been
T15572 27512-27515 VB denotes has
T15571 27507-27511 WDT denotes that
T15570 27500-27506 NN denotes family
T15569 27490-27499 NN denotes TLR/IL-1R
T15568 27486-27489 DT denotes the
T15567 27483-27485 IN denotes of
T15566 27476-27482 NN denotes member
T15565 27474-27475 DT denotes a
T15564 27471-27473 VB denotes is
T15563 27469-27470 -COMMA- denotes ,
T15562 27464-27469 NN denotes TIR-8
T15561 27461-27463 IN denotes as
T15560 27455-27460 VB denotes known
T15559 27450-27454 RB denotes also
T15558 27448-27449 -COMMA- denotes ,
T15557 27441-27448 NN denotes protein
T15556 27439-27440 -RRB- denotes )
T15555 27433-27439 NN denotes SIGIRR
T15554 27432-27433 -LRB- denotes (
T15553 27415-27431 JJ denotes receptor-related
T15552 27410-27414 NN denotes IL-1
T15551 27388-27409 JJ denotes Single-immunoglobulin
T15550 27380-27387 NN denotes protein
T15549 27363-27379 JJ denotes receptor-related
T15547 27336-27357 JJ denotes Single-immunoglobulin
T15764 28650-28652 NN denotes RA
T15763 28647-28649 IN denotes in
T15762 28640-28646 NN denotes target
T15761 28628-28639 JJ denotes therapeutic
T15760 28616-28627 JJ denotes interesting
T15759 28613-28615 DT denotes an
T15758 28610-28612 VB denotes be
T15757 28605-28609 RB denotes also
T15756 28601-28604 MD denotes may
T15755 28594-28600 NN denotes SIGIRR
T15754 28592-28593 -COMMA- denotes ,
T15753 28585-28592 NN denotes pattern
T15752 28574-28584 NN denotes expression
T15751 28563-28573 JJ denotes restricted
T15750 28559-28562 PRP-DOLLAR- denotes its
T15749 28556-28558 IN denotes of
T15748 28548-28555 IN denotes Because
T15747 28538-28546 NN denotes patients
T15746 28535-28537 NN denotes RA
T15745 28532-28534 IN denotes in
T15744 28520-28531 VB denotes compromised
T15743 28517-28519 VB denotes is
T15742 28510-28516 NN denotes SIGIRR
T15741 28507-28509 IN denotes of
T15740 28498-28506 NN denotes function
T15739 28494-28497 DT denotes the
T15738 28486-28493 IN denotes whether
T15737 28474-28485 VB denotes investigate
T15736 28471-28473 TO denotes to
T15735 28468-28470 CC denotes or
T15734 28466-28467 -COMMA- denotes ,
T15733 28458-28466 NN denotes patients
T15732 28450-28457 NN denotes control
T15731 28447-28449 IN denotes in
T15730 28436-28446 NN denotes expression
T15729 28432-28435 PRP-DOLLAR- denotes its
T15728 28427-28431 IN denotes with
T15727 28418-28426 NN denotes patients
T15726 28415-28417 NN denotes RA
T15725 28412-28414 IN denotes in
T15724 28405-28411 NN denotes SIGIRR
T15723 28402-28404 IN denotes of
T15722 28391-28401 NN denotes expression
T15721 28387-28390 DT denotes the
T15720 28379-28386 VB denotes compare
T15719 28376-28378 TO denotes to
T15718 28364-28375 JJ denotes interesting
T15717 28361-28363 VB denotes be
T15716 28356-28360 MD denotes will
T15715 28353-28355 PRP denotes It
T15714 28350-28351 -RRB- denotes ]
T15713 28348-28350 CD denotes 70
T15712 28347-28348 -LRB- denotes [
T15711 28340-28346 NN denotes models
T15710 28334-28339 NN denotes mouse
T15709 28324-28333 NN denotes arthritis
T15708 28307-28323 JJ denotes collagen-induced
T15707 28304-28306 IN denotes as
T15706 28299-28303 RB denotes well
T15705 28296-28298 RB denotes as
T15704 28294-28295 -COMMA- denotes ,
T15703 28285-28294 NN denotes arthritis
T15702 28269-28284 JJ denotes zymosan-induced
T15701 28266-28268 IN denotes in
T15700 28258-28265 NN denotes disease
T15699 28251-28257 JJ denotes severe
T15698 28246-28250 RB denotes more
T15697 28244-28245 DT denotes a
T15696 28234-28243 VB denotes developed
T15695 28229-28233 NN denotes mice
T15694 28212-28228 JJ denotes SIGIRR-deficient
T15693 28206-28211 IN denotes since
T15692 28204-28205 -COMMA- denotes ,
T15691 28200-28204 FW denotes vivo
T15690 28197-28199 FW denotes in
T15689 28187-28196 VB denotes confirmed
T15688 28179-28186 RB denotes further
T15687 28175-28178 VB denotes was
T15686 28168-28174 NN denotes SIGIRR
T15685 28165-28167 IN denotes of
T15684 28156-28164 NN denotes function
T15683 28145-28155 JJ denotes inhibitory
T15682 28140-28144 DT denotes This
T15681 28133-28138 NN denotes cells
T15680 28124-28132 JJ denotes synovial
T15679 28121-28123 NN denotes RA
T15678 28115-28120 JJ denotes human
T15677 28112-28114 IN denotes by
T15676 28102-28111 NN denotes cytokines
T15675 28089-28101 JJ denotes inflammatory
T15674 28086-28088 IN denotes of
T15673 28078-28085 NN denotes release
T15672 28066-28077 JJ denotes spontaneous
T15671 28062-28065 DT denotes the
T15670 28054-28061 VB denotes inhibit
T15669 28051-28053 TO denotes to
T15668 28045-28050 VB denotes shown
T15667 28041-28044 VB denotes was
T15666 28026-28040 NN denotes overexpression
T15665 28019-28025 NN denotes SIGIRR
T15664 28017-28018 -COMMA- denotes ,
T15663 28009-28017 RB denotes Recently
T15662 28006-28007 -RRB- denotes ]
T15661 28001-28006 CD denotes 69,70
T15660 28000-28001 -LRB- denotes [
T15659 27987-27999 NN denotes macro-phages
T15658 27980-27986 JJ denotes mature
T15657 27977-27979 IN denotes in
T15656 27973-27976 RB denotes not
T15655 27969-27972 CC denotes but
T15654 27967-27968 -COMMA- denotes ,
T15653 27962-27967 NN denotes cells
T15652 27952-27961 JJ denotes dendritic
T15651 27943-27951 JJ denotes immature
T15650 27939-27942 CC denotes and
T15649 27929-27938 NN denotes monocytes
T15648 27927-27928 -COMMA- denotes ,
T15647 27922-27927 NN denotes cells
T15646 27911-27921 JJ denotes epithelial
T15645 27908-27910 IN denotes in
T15644 27898-27907 VB denotes expressed
T15643 27892-27897 VB denotes being
T15642 27890-27891 -COMMA- denotes ,
T14577 27331-27333 NN denotes RA
T14576 27328-27330 IN denotes as
T14575 27323-27327 JJ denotes such
T14574 27313-27322 NN denotes disorders
T14573 27308-27312 NN denotes bone
T14572 27305-27307 IN denotes of
T14571 27295-27304 NN denotes pathology
T14570 27291-27294 DT denotes the
T14569 27288-27290 IN denotes in
T14568 27279-27287 VB denotes involved
T14567 27272-27278 NN denotes factor
T14566 27264-27271 JJ denotes genetic
T14565 27254-27263 JJ denotes potential
T14564 27252-27253 DT denotes a
T14563 27249-27251 IN denotes as
T14562 27244-27248 NN denotes CYLD
T14561 27235-27243 VB denotes indicate
T14560 27231-27234 CC denotes and
T14559 27212-27230 NN denotes osteoclastogenesis
T14558 27209-27211 IN denotes of
T14557 27198-27208 NN denotes regulation
T14556 27189-27197 JJ denotes negative
T14555 27185-27188 DT denotes the
T14554 27182-27184 IN denotes in
T14553 27177-27181 NN denotes role
T14552 27173-27176 JJ denotes key
T14551 27171-27172 DT denotes a
T14550 27165-27170 VB denotes plays
T14549 27154-27164 NN denotes signalling
T14548 27148-27153 NN denotes NF-κB
T14547 27135-27147 JJ denotes RANK-induced
T14546 27132-27134 IN denotes of
T14545 27120-27131 NN denotes inhibi-tion
T14544 27106-27119 JJ denotes CYLD-mediated
T14543 27101-27105 IN denotes that
T14542 27093-27100 VB denotes suggest
T14541 27084-27092 NN denotes findings
T14540 27078-27083 DT denotes These
T14539 27075-27076 -RRB- denotes ]
T14538 27073-27075 CD denotes 66
T14537 27072-27073 -LRB- denotes [
T14536 27067-27071 NN denotes loss
T14535 27062-27066 NN denotes bone
T14534 27050-27061 JJ denotes progressive
T14533 27042-27049 VB denotes develop
T14532 27038-27041 CC denotes and
T14531 27019-27037 NN denotes osteoclastogenesis
T14530 27010-27018 JJ denotes abnormal
T14529 27002-27009 VB denotes display
T14528 26997-27001 RB denotes also
T14527 26993-26996 NN denotes p62
T14526 26990-26992 IN denotes of
T14525 26985-26989 NN denotes form
T14524 26977-26984 VB denotes mutated
T14523 26975-26976 DT denotes a
T14522 26964-26974 VB denotes expressing
T14521 26959-26963 NN denotes mice
T14520 26948-26958 JJ denotes transgenic
T14519 26943-26947 IN denotes that
T14518 26932-26942 VB denotes mentioning
T14517 26926-26931 JJ denotes worth
T14516 26923-26925 VB denotes is
T14515 26920-26922 PRP denotes it
T14514 26918-26919 -COMMA- denotes ,
T14513 26911-26918 NN denotes context
T14512 26906-26910 DT denotes this
T14511 26903-26905 IN denotes In
T14510 26896-26901 NN denotes TRAF6
T14509 26893-26895 IN denotes of
T14508 26876-26892 NN denotes deubiquitination
T14507 26862-26875 JJ denotes CYLD-mediated
T14506 26858-26861 DT denotes the
T14505 26855-26857 IN denotes by
T14504 26846-26854 VB denotes followed
T14503 26844-26845 -COMMA- denotes ,
T14502 26843-26844 -RRB- denotes ]
T14501 26841-26843 CD denotes 65
T14500 26840-26841 -LRB- denotes [
T14499 26838-26839 -RRB- denotes )
T14498 26837-26838 CD denotes 1
T14497 26824-26836 NN denotes sequestosome
T14496 26821-26823 IN denotes as
T14495 26815-26820 VB denotes known
T14494 26810-26814 RB denotes also
T14493 26809-26810 -LRB- denotes (
T14492 26805-26808 NN denotes p62
T14491 26797-26804 NN denotes protein
T14490 26789-26796 NN denotes adaptor
T14489 26771-26788 JJ denotes ubiquitin-binding
T14488 26767-26770 DT denotes the
T14487 26763-26766 IN denotes via
T14486 26757-26762 NN denotes TRAF6
T14485 26743-26756 VB denotes ubiquitinated
T14484 26740-26742 TO denotes to
T14483 26730-26739 VB denotes recruited
T14482 26727-26729 VB denotes is
T14481 26723-26726 CC denotes and
T14480 26704-26722 NN denotes osteoclastogenesis
T14479 26690-26703 JJ denotes RANKL-induced
T14478 26687-26689 IN denotes of
T14477 26676-26686 NN denotes conditions
T14476 26670-26675 IN denotes under
T14475 26658-26669 VB denotes upregulated
T14474 26649-26657 RB denotes markedly
T14473 26646-26648 VB denotes is
T14472 26635-26645 NN denotes expression
T14471 26630-26634 NN denotes CYLD
T14470 26617-26628 NN denotes osteoclasts
T14469 26610-26616 JJ denotes larger
T14468 26606-26609 CC denotes and
T14467 26601-26605 JJ denotes more
T14466 26593-26600 VB denotes produce
T14465 26589-26592 CC denotes and
T14464 26573-26588 NN denotes differentiation
T14463 26559-26572 JJ denotes RANKL-induced
T14462 26556-26558 TO denotes to
T14461 26539-26555 JJ denotes hyper-responsive
T14460 26535-26538 VB denotes are
T14459 26530-26534 NN denotes mice
T14458 26524-26529 DT denotes these
T14457 26521-26523 IN denotes of
T14456 26510-26520 NN denotes precursors
T14455 26499-26509 NN denotes Osteoclast
T14454 26485-26497 NN denotes osteoporosis
T14453 26478-26484 JJ denotes severe
T14452 26470-26477 VB denotes develop
T14451 26466-26469 CC denotes and
T14450 26450-26465 NN denotes differentiation
T14449 26439-26449 NN denotes osteoclast
T14448 26430-26438 JJ denotes aberrant
T14447 26425-26429 VB denotes have
T14446 26420-26424 NN denotes CYLD
T14445 26417-26419 IN denotes of
T14444 26406-26416 NN denotes deficiency
T14443 26398-26405 JJ denotes genetic
T14442 26396-26397 DT denotes a
T14441 26391-26395 IN denotes with
T14440 26386-26390 NN denotes Mice
T14439 26383-26384 -RRB- denotes ]
T14438 26381-26383 CD denotes 65
T14437 26380-26381 -LRB- denotes [
T14436 26375-26379 NN denotes mice
T14435 26372-26374 IN denotes in
T14434 26353-26371 NN denotes osteoclastogenesis
T14433 26349-26352 CC denotes and
T14432 26338-26348 NN denotes signalling
T14431 26333-26337 NN denotes RANK
T14430 26324-26332 VB denotes regulate
T14429 26313-26323 RB denotes negatively
T14428 26310-26312 TO denotes to
T14427 26304-26309 VB denotes shown
T14426 26299-26303 VB denotes been
T14425 26295-26298 VB denotes has
T14424 26290-26294 NN denotes CYLD
T14423 26288-26289 -COMMA- denotes ,
T14422 26275-26288 RB denotes Interestingly
T14421 26272-26273 -RRB- denotes ]
T14420 26270-26272 CD denotes 64
T14419 26269-26270 -LRB- denotes [
T14418 26259-26268 JJ denotes dependent
T14417 26249-26258 JJ denotes cell-type
T14416 26246-26248 VB denotes be
T14415 26241-26245 RB denotes also
T14414 26235-26240 MD denotes might
T14413 26226-26234 NN denotes activity
T14265 25385-25389 NN denotes CYLD
T14264 25382-25383 -RRB- denotes ]
T14263 25380-25382 CD denotes 63
T14262 25379-25380 -LRB- denotes [
T14261 25363-25378 NN denotes cylindromatosis
T14260 25354-25362 JJ denotes familial
T14259 25351-25353 IN denotes in
T14258 25342-25350 VB denotes involved
T14257 25331-25341 NN denotes suppressor
T14256 25324-25330 NN denotes tumour
T14255 25322-25323 DT denotes a
T14254 25319-25321 IN denotes as
T14253 25308-25318 VB denotes identified
T14252 25297-25307 RB denotes originally
T14251 25293-25296 VB denotes was
T14250 25285-25292 NN denotes protein
T14249 25283-25284 -RRB- denotes )
T14248 25279-25283 NN denotes CYLD
T14247 25278-25279 -LRB- denotes (
T14246 25262-25277 NN denotes Cylindromatosis
T14245 25254-25261 NN denotes protein
T14244 25238-25253 NN denotes Cylindromatosis
T14412 26217-26225 JJ denotes relative
T14411 26211-26216 PRP-DOLLAR- denotes their
T14410 26209-26210 -COMMA- denotes ,
T14409 26201-26209 NN denotes addition
T14408 26198-26200 IN denotes In
T14407 26186-26196 NN denotes signalling
T14406 26180-26185 JJ denotes early
T14405 26176-26179 CC denotes and
T14404 26163-26175 JJ denotes constitutive
T14403 26154-26162 VB denotes regulate
T14402 26148-26153 MD denotes would
T14401 26143-26147 NN denotes CYLD
T14400 26135-26142 IN denotes whereas
T14399 26133-26134 -COMMA- denotes ,
T14398 26123-26133 NN denotes signalling
T14397 26117-26122 NN denotes NF-κB
T14396 26114-26116 IN denotes of
T14395 26107-26113 NN denotes phases
T14394 26101-26106 JJ denotes later
T14393 26091-26100 VB denotes regulates
T14392 26084-26090 RB denotes mainly
T14391 26076-26083 NN denotes protein
T14390 26071-26075 DT denotes this
T14389 26066-26070 IN denotes that
T14388 26056-26065 VB denotes suggested
T14387 26051-26055 VB denotes been
T14386 26047-26050 VB denotes has
T14385 26044-26046 PRP denotes it
T14384 26042-26043 -COMMA- denotes ,
T14383 26031-26042 NN denotes stimulation
T14382 26026-26030 IN denotes upon
T14381 26020-26025 NN denotes types
T14380 26015-26019 NN denotes cell
T14379 26010-26014 JJ denotes many
T14378 26007-26009 IN denotes in
T14377 25997-26006 VB denotes expressed
T14376 25992-25996 RB denotes only
T14375 25989-25991 VB denotes is
T14374 25985-25988 NN denotes A20
T14373 25982-25984 IN denotes As
T14372 25970-25980 NN denotes activation
T14371 25964-25969 NN denotes NF-κB
T14370 25956-25963 VB denotes control
T14369 25953-25955 TO denotes to
T14368 25948-25952 NN denotes CYLD
T14367 25945-25947 IN denotes as
T14366 25940-25944 RB denotes well
T14365 25937-25939 RB denotes as
T14364 25933-25936 NN denotes A20
T14363 25927-25932 VB denotes needs
T14362 25922-25926 NN denotes cell
T14361 25918-25921 DT denotes the
T14360 25914-25917 WRB denotes why
T14359 25908-25913 JJ denotes clear
T14358 25904-25907 RB denotes not
T14357 25898-25903 RB denotes still
T14356 25895-25897 VB denotes is
T14355 25892-25894 PRP denotes it
T14354 25888-25891 CC denotes and
T14353 25884-25887 NN denotes A20
T14352 25881-25883 IN denotes by
T14351 25872-25880 VB denotes targeted
T14350 25867-25871 RB denotes also
T14349 25863-25866 VB denotes are
T14348 25857-25862 DT denotes these
T14347 25854-25856 IN denotes of
T14346 25849-25853 JJ denotes Many
T14345 25843-25847 NN denotes TAK1
T14344 25839-25842 CC denotes and
T14343 25834-25838 NN denotes RIP1
T14342 25832-25833 -COMMA- denotes ,
T14341 25827-25832 NN denotes TRAF7
T14340 25825-25826 -COMMA- denotes ,
T14339 25820-25825 NN denotes TRAF6
T14338 25818-25819 -COMMA- denotes ,
T14337 25813-25818 NN denotes TRAF2
T14336 25811-25812 -COMMA- denotes ,
T14335 25807-25811 NN denotes NEMO
T14334 25797-25806 VB denotes including
T14333 25788-25796 NN denotes proteins
T14332 25777-25787 NN denotes signalling
T14331 25771-25776 NN denotes NF-κB
T14330 25763-25770 JJ denotes several
T14329 25745-25762 JJ denotes deubiquitina-ting
T14328 25742-25744 IN denotes by
T14327 25740-25741 -COMMA- denotes ,
T14326 25739-25740 -RRB- denotes )
T14325 25738-25739 CD denotes 1
T14324 25731-25737 NN denotes Figure
T14323 25730-25731 -LRB- denotes (
T14322 25728-25729 -RRB- denotes )
T14321 25727-25728 -RRB- denotes ]
T14320 25725-25727 CD denotes 64
T14319 25724-25725 -LRB- denotes [
T14318 25721-25723 IN denotes in
T14317 25712-25720 VB denotes reviewed
T14316 25711-25712 -LRB- denotes (
T14315 25699-25710 NN denotes stimulation
T14314 25690-25698 NN denotes receptor
T14313 25683-25689 NN denotes T-cell
T14312 25679-25682 CC denotes and
T14311 25674-25678 NN denotes RANK
T14310 25672-25673 -COMMA- denotes ,
T14309 25668-25672 NN denotes TNFR
T14308 25665-25667 IN denotes by
T14307 25655-25664 VB denotes initiated
T14306 25644-25654 NN denotes signalling
T14305 25638-25643 NN denotes NF-κB
T14304 25628-25637 VB denotes regulates
T14303 25617-25627 RB denotes negatively
T14302 25612-25616 WDT denotes that
T14301 25605-25611 NN denotes enzyme
T14300 25588-25604 VB denotes deubiquitinating
T14299 25586-25587 DT denotes a
T14298 25583-25585 VB denotes is
T14297 25578-25582 NN denotes CYLD
T14296 25575-25576 -RRB- denotes )
T14295 25574-25575 -RRB- denotes ]
T14294 25572-25574 CD denotes 64
T14293 25571-25572 -LRB- denotes [
T14292 25568-25570 IN denotes in
T14291 25559-25567 VB denotes reviewed
T14290 25558-25559 -LRB- denotes (
T14289 25539-25557 NN denotes osteoclastogenesis
T14288 25535-25538 CC denotes and
T14287 25533-25534 -COMMA- denotes ,
T14286 25518-25533 NN denotes spermatogenesis
T14285 25516-25517 -COMMA- denotes ,
T14284 25505-25516 NN denotes progression
T14283 25499-25504 NN denotes cycle
T14282 25494-25498 NN denotes cell
T14281 25491-25493 TO denotes to
T14280 25478-25490 NN denotes inflammation
T14279 25474-25477 CC denotes and
T14278 25465-25473 NN denotes immunity
T14277 25460-25464 IN denotes from
T14276 25452-25459 VB denotes ranging
T14275 25442-25451 NN denotes processes
T14274 25428-25441 JJ denotes physiological
T14273 25420-25427 JJ denotes diverse
T14272 25417-25419 IN denotes in
T14271 25415-25416 -COMMA- denotes ,
T14270 25408-25415 RB denotes however
T14269 25406-25407 -COMMA- denotes ,
T14268 25398-25406 VB denotes involved
T14267 25393-25397 RB denotes also
T14266 25390-25392 VB denotes is
T13114 25233-25235 NN denotes RA
T13113 25228-25232 IN denotes with
T13112 25217-25227 VB denotes associated
T13111 25212-25216 RB denotes also
T13110 25208-25211 VB denotes are
T13109 25194-25207 NN denotes erythematosus
T13108 25188-25193 NN denotes lupus
T13107 25179-25187 JJ denotes systemic
T13106 25174-25178 IN denotes with
T13105 25163-25173 VB denotes associated
T13104 25160-25162 VB denotes be
T13103 25157-25159 TO denotes to
T13102 25148-25156 VB denotes reported
T13101 25143-25147 VB denotes been
T13100 25138-25142 VB denotes have
T13099 25133-25137 WDT denotes that
T13098 25128-25132 NN denotes SNPs
T13097 25120-25127 IN denotes whether
T13096 25108-25119 VB denotes investigate
T13095 25105-25107 TO denotes to
T13094 25093-25104 JJ denotes interesting
T13093 25090-25092 VB denotes be
T13092 25080-25089 RB denotes therefore
T13091 25075-25079 MD denotes will
T13090 25072-25074 PRP denotes It
T13089 25069-25070 -RRB- denotes )
T13088 25060-25069 NN denotes rituximab
T13087 25059-25060 -LRB- denotes (
T13086 25049-25058 NN denotes depletion
T13085 25042-25048 NN denotes B-cell
T13084 25039-25041 IN denotes as
T13083 25034-25038 JJ denotes such
T13082 25023-25033 NN denotes treatments
T13081 25020-25022 TO denotes to
T13080 25011-25019 NN denotes response
T13079 25007-25010 CC denotes and
T13078 24998-25006 NN denotes features
T13077 24989-24997 JJ denotes systemic
T13076 24987-24988 -COMMA- denotes ,
T13075 24977-24987 NN denotes production
T13074 24964-24976 NN denotes autoantibody
T13073 24962-24963 -COMMA- denotes ,
T13072 24951-24962 NN denotes involvement
T13071 24945-24950 JJ denotes joint
T13070 24942-24944 IN denotes in
T13069 24934-24941 NN denotes overlap
T13068 24925-24933 JJ denotes clinical
T13067 24920-24924 DT denotes some
T13066 24915-24919 VB denotes show
T13065 24906-24914 NN denotes diseases
T13064 24902-24905 CD denotes two
T13063 24898-24901 DT denotes the
T13062 24895-24897 IN denotes as
T13061 24886-24894 VB denotes expected
T13060 24883-24885 VB denotes be
T13059 24877-24882 MD denotes might
T13058 24872-24876 NN denotes loci
T13057 24857-24871 NN denotes susceptibility
T13056 24854-24856 NN denotes RA
T13055 24850-24853 CC denotes and
T13054 24836-24849 NN denotes erythematosus
T13053 24830-24835 NN denotes lupus
T13052 24821-24829 JJ denotes systemic
T13051 24813-24820 IN denotes between
T13050 24805-24812 NN denotes overlap
T13049 24802-24804 IN denotes of
T13048 24795-24801 NN denotes degree
T13047 24790-24794 JJ denotes high
T13046 24788-24789 DT denotes A
T13045 24785-24786 -RRB- denotes ]
T13044 24780-24785 CD denotes 61,62
T13043 24779-24780 -LRB- denotes [
T13042 24772-24778 NN denotes humans
T13041 24769-24771 IN denotes in
T13040 24755-24768 NN denotes erythematosus
T13039 24749-24754 NN denotes lupus
T13038 24740-24748 JJ denotes systemic
T13037 24736-24739 CC denotes and
T13036 24726-24735 NN denotes psoriasis
T13035 24721-24725 IN denotes with
T13034 24710-24720 VB denotes associated
T13033 24705-24709 VB denotes been
T13032 24700-24704 VB denotes have
T13031 24686-24699 NN denotes polymorphisms
T13030 24679-24685 NN denotes ABIN-1
T13029 24677-24678 -COMMA- denotes ,
T13028 24664-24677 RB denotes Interestingly
T13027 24661-24662 -RRB- denotes ]
T13026 24659-24661 CD denotes 60
T13025 24658-24659 -LRB- denotes [
T13024 24646-24657 NN denotes macrophages
T13023 24637-24645 JJ denotes synovial
T13022 24627-24636 NN denotes arthritis
T13021 24614-24626 JJ denotes inflammatory
T13020 24611-24613 IN denotes in
T13019 24600-24610 VB denotes suppressed
T13018 24591-24599 RB denotes strongly
T13017 24587-24590 VB denotes was
T13016 24582-24586 NNP denotes ITAM
T13015 24578-24581 DT denotes the
T13014 24575-24577 IN denotes of
T13013 24568-24574 NN denotes effect
T13012 24557-24567 JJ denotes protective
T13011 24552-24556 DT denotes this
T13010 24550-24551 -COMMA- denotes ,
T13009 24542-24550 RB denotes Moreover
T13008 24537-24540 NN denotes A20
T13007 24533-24536 CC denotes and
T13006 24526-24532 NN denotes ABIN-3
T13005 24517-24525 NN denotes proteins
T13004 24506-24516 JJ denotes inhibitory
T13003 24500-24505 NN denotes NF-κB
T13002 24496-24499 DT denotes the
T13001 24493-24495 IN denotes of
T13000 24482-24492 NN denotes expression
T12999 24478-24481 DT denotes the
T12998 24475-24477 IN denotes on
T12997 24468-24474 VB denotes depend
T12996 24465-24467 TO denotes to
T12995 24459-24464 VB denotes shown
T12994 24455-24458 VB denotes was
T12993 24445-24454 NN denotes receptors
T12992 24436-24444 JJ denotes -coupled
T12991 24435-24436 -RRB- denotes )
T12990 24431-24435 NN denotes ITAM
T12989 24430-24431 -LRB- denotes (
T12988 24424-24429 NN denotes motif
T12987 24413-24423 NN denotes activation
T12986 24398-24412 JJ denotes tyrosine-based
T12985 24383-24397 NN denotes immunoreceptor
T12984 24380-24382 IN denotes by
T12983 24370-24379 NN denotes responses
T12982 24366-24369 NN denotes TLR
T12981 24363-24365 IN denotes of
T12980 24352-24362 NN denotes inhibition
T12979 24350-24351 -COMMA- denotes ,
T12978 24345-24350 NN denotes study
T12977 24338-24344 JJ denotes recent
T12976 24336-24337 DT denotes a
T12975 24333-24335 IN denotes In
T12974 24330-24331 -RRB- denotes ]
T12973 24328-24330 CD denotes 59
T12972 24327-24328 -LRB- denotes [
T12971 24324-24326 NN denotes RA
T12970 24321-24323 IN denotes of
T12969 24308-24320 NN denotes pathogenesis
T12968 24304-24307 DT denotes the
T12967 24300-24303 CC denotes and
T12966 24289-24299 NN denotes signalling
T12965 24283-24288 NN denotes NF-κB
T12964 24280-24282 IN denotes of
T12963 24269-24279 NN denotes regulation
T12962 24260-24268 NN denotes feedback
T12961 24251-24259 JJ denotes negative
T12960 24247-24250 DT denotes the
T12959 24244-24246 IN denotes in
T12958 24242-24243 -COMMA- denotes ,
T12957 24239-24242 NN denotes A20
T12956 24234-24238 IN denotes with
T12955 24225-24233 RB denotes together
T12954 24223-24224 -COMMA- denotes ,
T12953 24217-24223 NN denotes ABIN-1
T12952 24213-24216 IN denotes for
T12951 24208-24212 NN denotes role
T12950 24198-24207 JJ denotes potential
T12949 24196-24197 DT denotes a
T12948 24185-24195 VB denotes indicating
T12947 24183-24184 -COMMA- denotes ,
T12946 24175-24183 NN denotes biopsies
T12945 24168-24174 NN denotes tissue
T12944 24165-24167 NN denotes RA
T12943 24162-24164 IN denotes in
T12942 24153-24161 VB denotes detected
T12753 22953-22954 -COMMA- denotes ,
T12752 22947-22953 NN denotes TNIP-2
T12751 22945-22946 -COMMA- denotes ,
T12750 22939-22945 NN denotes TNIP-1
T12749 22936-22938 IN denotes as
T12748 22930-22935 VB denotes known
T12747 22925-22929 RB denotes also
T12746 22924-22925 -LRB- denotes (
T12745 22917-22923 NN denotes ABIN-3
T12744 22913-22916 CC denotes and
T12743 22906-22912 NN denotes ABIN-2
T12742 22904-22905 -COMMA- denotes ,
T12741 22898-22904 NN denotes ABIN-1
T12740 22892-22897 NN denotes NF-κB
T12739 22889-22891 IN denotes of
T12738 22878-22888 NN denotes inhibitors
T12737 22866-22877 JJ denotes A20-binding
T12941 24148-24152 VB denotes were
T12940 24143-24147 NN denotes mRNA
T12939 24136-24142 NN denotes ABIN-1
T12938 24133-24135 IN denotes of
T12937 24126-24132 NN denotes levels
T12936 24121-24125 JJ denotes high
T12935 24117-24120 CC denotes and
T12934 24115-24116 -COMMA- denotes ,
T12933 24103-24115 NN denotes synoviocytes
T12932 24097-24102 JJ denotes human
T12931 24094-24096 IN denotes in
T12930 24088-24093 NN denotes genes
T12929 24076-24087 JJ denotes TNF-induced
T12928 24070-24075 IN denotes among
T12927 24059-24069 VB denotes identified
T12926 24055-24058 VB denotes was
T12925 24048-24054 NN denotes ABIN-1
T12924 24046-24047 -COMMA- denotes ,
T12923 24038-24046 NN denotes analysis
T12922 24027-24037 NN denotes microarray
T12921 24011-24026 NN denotes oligonucleotide
T12920 24005-24010 VB denotes Using
T12919 24002-24003 -RRB- denotes ]
T12918 24000-24002 CD denotes 56
T12917 23999-24000 -LRB- denotes [
T12916 23989-23998 NN denotes apoptosis
T12915 23983-23988 NN denotes liver
T12914 23976-23982 JJ denotes foetal
T12913 23962-23975 JJ denotes TNF-dependent
T12912 23959-23961 TO denotes to
T12911 23955-23958 JJ denotes due
T12910 23941-23954 RB denotes embryonically
T12909 23937-23940 VB denotes die
T12908 23932-23936 NN denotes mice
T12907 23922-23931 JJ denotes deficient
T12906 23915-23921 NN denotes ABIN-1
T12905 23911-23914 CC denotes and
T12904 23909-23910 -COMMA- denotes ,
T12903 23908-23909 -RRB- denotes ]
T12902 23906-23908 CD denotes 58
T12901 23905-23906 -LRB- denotes [
T12900 23895-23904 NN denotes apoptosis
T12899 23883-23894 JJ denotes TNF-induced
T12898 23874-23882 VB denotes inhibits
T12897 23865-23873 RB denotes strongly
T12896 23860-23864 RB denotes also
T12895 23853-23859 NN denotes ABIN-1
T12894 23851-23852 -COMMA- denotes ,
T12893 23848-23851 NN denotes A20
T12892 23844-23847 IN denotes for
T12891 23841-23843 IN denotes As
T12890 23838-23839 -RRB- denotes ]
T12889 23836-23838 CD denotes 57
T12888 23835-23836 -LRB- denotes [
T12887 23828-23834 NN denotes domain
T12886 23810-23827 JJ denotes ubiquitin-binding
T12885 23802-23809 JJ denotes crucial
T12884 23798-23801 DT denotes the
T12883 23790-23797 VB denotes lacking
T12882 23785-23789 NN denotes form
T12881 23776-23784 JJ denotes inactive
T12880 23772-23775 CC denotes and
T12879 23762-23771 VB denotes truncated
T12878 23760-23761 DT denotes a
T12877 23752-23759 VB denotes express
T12876 23747-23751 RB denotes only
T12875 23742-23746 NN denotes mice
T12874 23738-23741 CC denotes but
T12873 23736-23737 -COMMA- denotes ,
T12872 23730-23736 NN denotes humans
T12871 23727-23729 IN denotes in
T12870 23717-23726 VB denotes expressed
T12869 23714-23716 VB denotes is
T12868 23707-23713 NN denotes ABIN-3
T12867 23696-23706 JJ denotes Functional
T12866 23693-23694 -RRB- denotes ]
T12865 23688-23693 CD denotes 55,56
T12864 23687-23688 -LRB- denotes [
T12863 23681-23686 NN denotes ABINs
T12862 23672-23680 JJ denotes multiple
T12861 23669-23671 IN denotes of
T12860 23658-23668 NN denotes activities
T12859 23647-23657 JJ denotes inhibitory
T12858 23641-23646 NN denotes NF-κB
T12857 23631-23640 JJ denotes redundant
T12856 23620-23630 VB denotes reflecting
T12855 23611-23619 RB denotes possibly
T12854 23609-23610 -COMMA- denotes ,
T12853 23597-23609 RB denotes respectively
T12852 23595-23596 -COMMA- denotes ,
T12851 23586-23595 NN denotes responses
T12850 23580-23585 NN denotes NF-κB
T12849 23573-23579 JJ denotes normal
T12848 23570-23572 CC denotes or
T12847 23560-23569 VB denotes increased
T12846 23551-23559 RB denotes slightly
T12845 23546-23550 RB denotes only
T12844 23538-23545 VB denotes exhibit
T12843 23533-23537 NN denotes mice
T12842 23516-23532 JJ denotes ABIN-2-deficient
T12841 23512-23515 CC denotes and
T12840 23495-23511 JJ denotes ABIN-1-deficient
T12839 23490-23494 CC denotes both
T12838 23488-23489 -COMMA- denotes ,
T12837 23476-23488 RB denotes Unexpectedly
T12836 23473-23474 -RRB- denotes )
T12835 23472-23473 -RRB- denotes ]
T12834 23470-23472 CD denotes 54
T12833 23469-23470 -LRB- denotes [
T12832 23466-23468 IN denotes in
T12831 23457-23465 VB denotes reviewed
T12830 23456-23457 -LRB- denotes (
T12829 23445-23455 NN denotes activation
T12828 23439-23444 NN denotes NF-κB
T12827 23436-23438 IN denotes of
T12826 23425-23435 NN denotes regulation
T12825 23416-23424 NN denotes feedback
T12824 23407-23415 JJ denotes negative
T12823 23403-23406 DT denotes the
T12822 23400-23402 IN denotes in
T12821 23392-23399 NN denotes complex
T12820 23383-23391 NN denotes A20/ABIN
T12819 23379-23382 DT denotes the
T12818 23375-23378 IN denotes for
T12817 23370-23374 NN denotes role
T12816 23360-23369 JJ denotes potential
T12815 23358-23359 DT denotes a
T12814 23346-23357 VB denotes implicating
T12813 23344-23345 -COMMA- denotes ,
T12812 23335-23344 JJ denotes dependent
T12811 23329-23334 NN denotes NF-κB
T12810 23326-23328 VB denotes is
T12809 23315-23325 NN denotes expression
T12808 23308-23314 NN denotes ABIN-3
T12807 23304-23307 CC denotes and
T12806 23297-23303 NN denotes ABIN-1
T12805 23295-23296 -COMMA- denotes ,
T12804 23292-23295 NN denotes A20
T12803 23289-23291 TO denotes to
T12802 23281-23288 JJ denotes Similar
T12801 23278-23279 -RRB- denotes ]
T12800 23273-23278 CD denotes 43,44
T12799 23272-23273 -LRB- denotes [
T12798 23261-23271 NN denotes substrates
T12797 23243-23260 VB denotes polyubiquitinated
T12796 23240-23242 TO denotes to
T12795 23236-23239 NN denotes A20
T12794 23229-23235 VB denotes target
T12793 23226-23228 TO denotes to
T12792 23217-23225 VB denotes proposed
T12791 23212-23216 VB denotes been
T12790 23207-23211 VB denotes have
T12789 23202-23206 PRP denotes they
T12788 23200-23201 -COMMA- denotes ,
T12787 23195-23200 NN denotes motif
T12786 23177-23194 JJ denotes ubiquitin-binding
T12785 23168-23176 JJ denotes specific
T12784 23166-23167 DT denotes a
T12783 23158-23165 VB denotes contain
T12782 23152-23157 NN denotes ABINs
T12781 23144-23151 IN denotes Because
T12780 23128-23142 NN denotes overexpression
T12779 23123-23127 IN denotes upon
T12778 23115-23122 NN denotes stimuli
T12777 23102-23114 JJ denotes inflammatory
T12776 23096-23101 JJ denotes other
T12775 23088-23095 JJ denotes several
T12774 23084-23087 CC denotes and
T12773 23080-23083 NN denotes TNF
T12772 23077-23079 IN denotes by
T12771 23066-23076 NN denotes activation
T12770 23060-23065 NN denotes NF-κB
T12769 23052-23059 VB denotes inhibit
T12768 23049-23051 TO denotes to
T12767 23043-23048 VB denotes shown
T12766 23038-23042 VB denotes were
T12765 23034-23037 CC denotes and
T12764 23025-23033 NN denotes proteins
T12763 23013-23024 VB denotes interacting
T12762 23009-23012 NN denotes A20
T12761 22999-23008 VB denotes expressed
T12760 22986-22998 RB denotes ubiquitously
T12759 22983-22985 IN denotes as
T12758 22972-22982 VB denotes identified
T12757 22967-22971 VB denotes were
T12756 22965-22966 -RRB- denotes )
T12755 22959-22965 NN denotes TNIP-3
T12754 22955-22958 CC denotes and
T10168 20124-20130 PRP denotes itself
T10253 20665-20672 NN denotes protein
T10252 20648-20664 JJ denotes chemo-attractant
T10251 20639-20647 NN denotes monocyte
T10250 20637-20638 -COMMA- denotes ,
T10249 20632-20637 NN denotes RANKL
T10248 20624-20631 JJ denotes soluble
T10247 20622-20623 -COMMA- denotes ,
T10246 20618-20622 NN denotes IL-6
T10245 20616-20617 -COMMA- denotes ,
T10244 20611-20616 NN denotes IL-1β
T10243 20609-20610 -COMMA- denotes ,
T10242 20606-20609 NN denotes TNF
T10241 20603-20605 IN denotes of
T10240 20596-20602 NN denotes levels
T10239 20586-20595 VB denotes decreased
T10238 20582-20585 CC denotes and
T10237 20573-20581 NN denotes activity
T10236 20567-20572 NN denotes NF-κB
T10235 20564-20566 IN denotes of
T10234 20553-20563 NN denotes inhibition
T10233 20548-20552 IN denotes with
T10232 20537-20547 VB denotes associated
T10231 20533-20536 VB denotes was
T10230 20526-20532 NN denotes tissue
T10229 20517-20525 JJ denotes synovial
T10228 20514-20516 IN denotes in
T10227 20503-20513 NN denotes expression
T10226 20499-20502 NN denotes A20
T10225 20490-20497 NN denotes setting
T10224 20478-20489 JJ denotes therapeutic
T10223 20474-20477 CC denotes and
T10222 20461-20473 JJ denotes prophylactic
T10221 20459-20460 DT denotes a
T10220 20454-20458 CC denotes both
T10219 20451-20453 IN denotes in
T10218 20449-20450 -COMMA- denotes ,
T10217 20443-20449 NN denotes joints
T10216 20433-20442 JJ denotes untreated
T10215 20430-20432 IN denotes in
T10214 20425-20429 RB denotes even
T10213 20423-20424 -COMMA- denotes ,
T10212 20414-20423 NN denotes arthritis
T10211 20397-20413 JJ denotes collagen-induced
T10210 20394-20396 IN denotes of
T10209 20388-20393 NN denotes model
T10208 20382-20387 NN denotes mouse
T10207 20380-20381 DT denotes a
T10206 20377-20379 IN denotes in
T10205 20365-20376 NN denotes destruction
T10204 20359-20364 JJ denotes joint
T10203 20355-20358 CC denotes and
T10202 20342-20354 NN denotes inflammation
T10201 20333-20341 JJ denotes synovial
T10200 20330-20332 IN denotes of
T10199 20321-20329 NN denotes severity
T10198 20317-20320 DT denotes the
T10197 20310-20316 VB denotes reduce
T10196 20307-20309 TO denotes to
T10195 20301-20306 VB denotes shown
T10194 20297-20300 VB denotes was
T10193 20286-20296 NN denotes adenovirus
T10192 20271-20285 JJ denotes A20-expressing
T10191 20268-20270 DT denotes an
T10190 20265-20267 IN denotes of
T10189 20255-20264 NN denotes injection
T10188 20239-20254 JJ denotes intra-articular
T10187 20237-20238 -COMMA- denotes ,
T10186 20229-20237 RB denotes Recently
T10185 20217-20227 NN denotes signalling
T10184 20211-20216 NN denotes NF-κB
T10183 20208-20210 IN denotes of
T10182 20197-20207 NN denotes regulation
T10181 20188-20196 NN denotes feedback
T10180 20179-20187 JJ denotes negative
T10179 20175-20178 DT denotes the
T10178 20172-20174 IN denotes in
T10177 20168-20171 NN denotes A20
T10176 20156-20167 VB denotes implicating
T10175 20154-20155 -COMMA- denotes ,
T10174 20153-20154 -RRB- denotes ]
T10173 20151-20153 CD denotes 50
T10172 20150-20151 -LRB- denotes [
T10171 20144-20149 NN denotes NF-κB
T10170 20141-20143 IN denotes by
T10169 20131-20140 VB denotes regulated
T10167 20121-20123 VB denotes is
T10166 20110-20120 NN denotes expression
T10165 20106-20109 NN denotes A20
T10164 20104-20105 -COMMA- denotes ,
T10163 20091-20104 RB denotes Interestingly
T10162 20078-20089 NN denotes lymphocytes
T10161 20074-20077 CC denotes and
T10160 20061-20073 NN denotes synoviocytes
T10159 20059-20060 -COMMA- denotes ,
T10158 20048-20059 NN denotes fibroblasts
T10157 20045-20047 IN denotes as
T10156 20040-20044 JJ denotes such
T10155 20038-20039 -COMMA- denotes ,
T10154 20036-20038 NN denotes RA
T10153 20033-20035 IN denotes of
T10152 20017-20032 NN denotes pathophysiology
T10151 20013-20016 DT denotes the
T10150 20010-20012 IN denotes in
T10149 20004-20009 NN denotes roles
T10148 19994-20003 JJ denotes important
T10147 19989-19993 VB denotes play
T10146 19984-19988 WDT denotes that
T10145 19978-19983 NN denotes types
T10144 19973-19977 NN denotes cell
T10143 19965-19972 JJ denotes several
T10142 19962-19964 IN denotes in
T10141 19953-19961 VB denotes observed
T10140 19948-19952 VB denotes been
T10139 19944-19947 VB denotes has
T10138 19933-19943 NN denotes expression
T10137 19929-19932 NN denotes A20
T10136 19926-19927 -RRB- denotes ]
T10135 19921-19926 CD denotes 48,49
T10134 19920-19921 -LRB- denotes [
T10133 19911-19919 NN denotes survival
T10132 19904-19910 NN denotes B-cell
T10131 19891-19903 JJ denotes unrestricted
T10130 19888-19890 TO denotes to
T10129 19880-19887 VB denotes leading
T10128 19874-19879 NN denotes cells
T10127 19872-19873 NN denotes B
T10126 19869-19871 IN denotes in
T10125 19859-19868 NN denotes responses
T10124 19853-19858 NN denotes NF-κB
T10123 19841-19852 JJ denotes hyperactive
T10122 19838-19840 TO denotes to
T10121 19834-19837 JJ denotes due
T10120 19821-19833 NN denotes autoimmunity
T10119 19813-19820 VB denotes develop
T10118 19807-19812 NN denotes cells
T10117 19805-19806 NN denotes B
T10116 19802-19804 IN denotes in
T10115 19798-19801 NN denotes A20
T10114 19790-19797 VB denotes lacking
T10113 19785-19789 NN denotes mice
T10112 19780-19784 IN denotes that
T10111 19773-19779 VB denotes showed
T10110 19765-19772 NN denotes studies
T10109 19753-19764 JJ denotes independent
T10108 19749-19752 CD denotes Two
T10107 19746-19747 -RRB- denotes ]
T10106 19744-19746 CD denotes 47
T10105 19743-19744 -LRB- denotes [
T10104 19732-19742 NN denotes epithelium
T10103 19721-19731 JJ denotes intestinal
T10102 19717-19720 DT denotes the
T10101 19714-19716 IN denotes in
T10100 19706-19713 NN denotes protein
T10099 19692-19705 JJ denotes antiapoptotic
T10098 19686-19691 JJ denotes major
T10097 19684-19685 DT denotes a
T10096 19681-19683 IN denotes as
T10095 19677-19680 NN denotes A20
T10094 19666-19676 VB denotes confirming
T10093 19664-19665 -COMMA- denotes ,
T10092 19655-19664 NN denotes apoptosis
T10091 19643-19654 JJ denotes TNF-induced
T10090 19640-19642 TO denotes to
T10089 19634-19639 NN denotes cells
T10088 19623-19633 JJ denotes epithelial
T10087 19612-19622 JJ denotes intestinal
T10086 19606-19611 PRP-DOLLAR- denotes their
T10085 19603-19605 IN denotes of
T10084 19586-19602 NN denotes hypersensitivity
T10083 19582-19585 DT denotes the
T10082 19579-19581 TO denotes to
T10081 19575-19578 JJ denotes due
T10080 19567-19574 NN denotes colitis
T10079 19554-19566 JJ denotes experimental
T10078 19551-19553 TO denotes to
T10077 19536-19550 NN denotes susceptibility
T10076 19526-19535 VB denotes increased
T10075 19518-19525 VB denotes exhibit
T10074 19512-19517 NN denotes cells
T10073 19501-19511 JJ denotes epithelial
T10072 19490-19500 JJ denotes intestinal
T10071 19487-19489 IN denotes in
T10070 19483-19486 NN denotes A20
T10069 19475-19482 VB denotes lacking
T10068 19462-19474 RB denotes specifically
T10067 19457-19461 NN denotes mice
T10066 19452-19456 IN denotes that
T10065 19445-19451 VB denotes showed
T10064 19436-19444 RB denotes recently
T10063 19433-19435 PRP denotes We
T10062 19424-19431 NN denotes protein
T10061 19410-19423 JJ denotes antiapoptotic
T10060 19407-19409 DT denotes an
T10059 19404-19406 IN denotes as
T10058 19399-19403 NN denotes role
T10057 19395-19398 PRP-DOLLAR- denotes its
T10056 19384-19394 VB denotes confirming
T10055 19382-19383 -COMMA- denotes ,
T10054 19373-19382 NN denotes apoptosis
T10053 19360-19372 JJ denotes TNF-mediated
T10052 19357-19359 TO denotes to
T10051 19345-19356 JJ denotes susceptible
T10050 19340-19344 RB denotes more
T10049 19335-19339 RB denotes also
T10048 19331-19334 VB denotes are
T10047 19325-19330 NN denotes cells
T10046 19311-19324 JJ denotes A20-deficient
T10045 19308-19309 -RRB- denotes ]
T10044 19306-19308 CD denotes 46
T10043 19305-19306 -LRB- denotes [
T10042 19296-19304 NN denotes molecule
T10041 19291-19295 DT denotes this
T10040 19288-19290 IN denotes of
T10039 19279-19287 NN denotes function
T10038 19261-19278 JJ denotes anti-inflammatory
T10443 21845-21849 NN denotes 6q23
T10442 21841-21844 DT denotes the
T10441 21838-21840 IN denotes in
T10440 21832-21837 NN denotes locus
T10439 21828-21831 NN denotes A20
T10438 21824-21827 DT denotes the
T10437 21821-21823 IN denotes in
T10436 21811-21820 NN denotes mutations
T10435 21803-21810 IN denotes between
T10434 21791-21802 NN denotes association
T10433 21785-21790 JJ denotes clear
T10432 21783-21784 DT denotes a
T10431 21774-21782 VB denotes revealed
T10430 21769-21773 RB denotes also
T10429 21761-21768 NN denotes studies
T10428 21749-21760 NN denotes association
T10427 21737-21748 JJ denotes genome-wide
T10426 21729-21736 JJ denotes Several
T10425 21726-21727 -RRB- denotes )
T10424 21725-21726 -RRB- denotes ]
T10423 21723-21725 CD denotes 52
T10422 21722-21723 -LRB- denotes [
T10421 21719-21721 IN denotes in
T10420 21710-21718 VB denotes reviewed
T10419 21709-21710 -LRB- denotes (
T10418 21697-21708 NN denotes pathologies
T10417 21686-21696 JJ denotes autoimmune
T10416 21683-21685 IN denotes of
T10415 21671-21682 NN denotes development
T10414 21668-21670 TO denotes to
T10413 21653-21667 NN denotes susceptibility
T10412 21643-21652 VB denotes increased
T10411 21638-21642 IN denotes with
T10410 21627-21637 VB denotes associated
T10409 21622-21626 VB denotes been
T10408 21617-21621 VB denotes have
T10407 21611-21616 NN denotes locus
T10406 21607-21610 NN denotes A20
T10405 21601-21606 JJ denotes human
T10404 21597-21600 DT denotes the
T10403 21594-21596 IN denotes in
T10402 21589-21593 NN denotes SNPs
T10401 21581-21588 JJ denotes several
T10400 21579-21580 -COMMA- denotes ,
T10399 21568-21579 RB denotes Importantly
T10398 21561-21566 NN denotes cells
T10397 21559-21560 NN denotes T
T10396 21556-21558 CC denotes or
T10395 21550-21555 NN denotes cells
T10394 21548-21549 NN denotes B
T10393 21546-21547 -COMMA- denotes ,
T10392 21541-21546 NN denotes cells
T10391 21531-21540 JJ denotes dendritic
T10390 21529-21530 -COMMA- denotes ,
T10389 21518-21529 NN denotes macrophages
T10388 21516-21517 -COMMA- denotes ,
T10387 21505-21516 NN denotes fibroblasts
T10386 21496-21504 JJ denotes synovial
T10385 21493-21495 IN denotes as
T10384 21488-21492 JJ denotes such
T10383 21482-21487 NN denotes types
T10382 21477-21481 NN denotes cell
T10381 21468-21476 JJ denotes specific
T10380 21465-21467 IN denotes in
T10379 21461-21464 NN denotes A20
T10378 21456-21460 VB denotes lack
T10377 21451-21455 WDT denotes that
T10376 21446-21450 NN denotes mice
T10375 21437-21445 NN denotes knockout
T10374 21425-21436 JJ denotes conditional
T10373 21422-21424 IN denotes of
T10372 21407-21421 NN denotes susceptibility
T10371 21403-21406 DT denotes the
T10370 21396-21402 JJ denotes future
T10369 21393-21395 IN denotes in
T10368 21385-21392 VB denotes analyse
T10367 21382-21384 TO denotes to
T10366 21370-21381 JJ denotes interesting
T10365 21367-21369 VB denotes be
T10364 21362-21366 MD denotes will
T10363 21359-21361 PRP denotes It
T10362 21349-21357 NN denotes activity
T10361 21345-21348 CC denotes and
T10360 21338-21344 NN denotes number
T10359 21327-21337 NN denotes osteoclast
T10358 21323-21326 DT denotes the
T10357 21312-21322 VB denotes decreasing
T10356 21304-21311 IN denotes through
T10355 21292-21303 NN denotes destruction
T10354 21286-21291 JJ denotes joint
T10353 21277-21285 VB denotes minimise
T10352 21267-21276 RB denotes therefore
T10351 21261-21266 MD denotes might
T10350 21257-21260 NN denotes A20
T10349 21249-21255 NN denotes tissue
T10348 21243-21248 JJ denotes joint
T10347 21240-21242 IN denotes in
T10346 21228-21239 NN denotes osteoclasts
T10345 21218-21227 VB denotes activated
T10344 21215-21217 IN denotes of
T10343 21208-21214 NN denotes number
T10342 21204-21207 DT denotes the
T10341 21201-21203 IN denotes in
T10340 21192-21200 NN denotes decrease
T10339 21190-21191 DT denotes a
T10338 21187-21189 TO denotes to
T10337 21181-21186 VB denotes leads
T10336 21166-21180 NN denotes overexpression
T10335 21162-21165 NN denotes A20
T10334 21157-21161 IN denotes that
T10333 21144-21156 VB denotes demonstrated
T10332 21139-21143 RB denotes also
T10331 21133-21138 NN denotes study
T10330 21128-21132 DT denotes This
T10329 21118-21126 NN denotes findings
T10328 21105-21117 JJ denotes radiological
T10327 21101-21104 CC denotes and
T10326 21099-21100 -COMMA- denotes ,
T10325 21087-21099 JJ denotes pathological
T10324 21085-21086 -COMMA- denotes ,
T10323 21077-21085 JJ denotes clinical
T10322 21073-21076 DT denotes the
T10321 21070-21072 IN denotes in
T10320 21062-21069 NN denotes effects
T10319 21051-21061 JJ denotes beneficial
T10318 21047-21050 DT denotes the
T10317 21039-21046 VB denotes explain
T10316 21033-21038 MD denotes might
T10315 21028-21032 NN denotes mice
T10314 21013-21027 JJ denotes A20-transduced
T10313 21010-21012 IN denotes in
T10312 21004-21009 NN denotes IL-1β
T10311 21000-21003 CC denotes and
T10310 20996-20999 NN denotes TNF
T10309 20993-20995 IN denotes of
T10308 20986-20992 NN denotes levels
T10307 20980-20985 NN denotes serum
T10306 20970-20979 VB denotes decreased
T10305 20966-20969 DT denotes the
T10304 20964-20965 -COMMA- denotes ,
T10303 20962-20964 NN denotes RA
T10302 20959-20961 IN denotes in
T10301 20954-20958 NN denotes bone
T10300 20950-20953 CC denotes and
T10299 20940-20949 NN denotes cartilage
T10298 20937-20939 IN denotes of
T10297 20929-20936 NN denotes erosion
T10296 20925-20928 CC denotes and
T10295 20923-20924 -COMMA- denotes ,
T10294 20914-20923 NN denotes formation
T10293 20907-20913 NN denotes pannus
T10292 20905-20906 -COMMA- denotes ,
T10291 20896-20905 NN denotes synovitis
T10290 20888-20895 VB denotes mediate
T10289 20885-20887 TO denotes to
T10288 20879-20884 VB denotes known
T10287 20875-20878 VB denotes are
T10286 20869-20874 NN denotes IL-1β
T10285 20865-20868 CC denotes and
T10284 20861-20864 NN denotes TNF
T10283 20853-20860 IN denotes Because
T10282 20850-20851 -RRB- denotes ]
T10281 20848-20850 CD denotes 51
T10280 20847-20848 -LRB- denotes [
T10279 20836-20846 NN denotes expression
T10278 20831-20835 NN denotes gene
T10277 20818-20830 JJ denotes κB-dependent
T10276 20814-20817 NF- denotes NF-
T10275 20810-20813 CC denotes and
T10274 20799-20809 NN denotes activation
T10273 20793-20798 NN denotes NF-κB
T10272 20790-20792 IN denotes of
T10271 20778-20789 NN denotes suppression
T10270 20770-20777 IN denotes through
T10269 20765-20769 NN denotes mice
T10268 20755-20764 NN denotes arthritis
T10267 20738-20754 JJ denotes collagen-induced
T10266 20735-20737 IN denotes in
T10265 20728-20734 NN denotes effect
T10264 20717-20727 JJ denotes protective
T10263 20715-20716 DT denotes a
T10262 20707-20714 VB denotes induces
T10261 20703-20706 NN denotes A20
T10260 20698-20702 IN denotes that
T10259 20687-20697 VB denotes suggesting
T10258 20685-20686 -COMMA- denotes ,
T10257 20680-20685 NN denotes IL-17
T10256 20676-20679 CC denotes and
T10255 20674-20675 -COMMA- denotes ,
T10254 20673-20674 CD denotes 1
T9976 18895-18902 NN denotes protein
T9975 18882-18894 JJ denotes Tax1-binding
T9974 18878-18881 CC denotes and
T9973 18876-18877 CD denotes 1
T9972 18874-18875 -RRB- denotes )
T9971 18870-18874 NN denotes ABIN
T9970 18869-18870 -LRB- denotes (
T9969 18863-18868 NN denotes NF-κB
T9968 18860-18862 IN denotes of
T9967 18850-18859 NN denotes inhibitor
T9966 18838-18849 JJ denotes A20-binding
T9965 18828-18837 VB denotes including
T9964 18826-18827 -COMMA- denotes ,
T9963 18818-18826 NN denotes proteins
T9962 18810-18817 NN denotes adaptor
T9961 18792-18809 JJ denotes ubiquitin-binding
T9960 18783-18791 JJ denotes specific
T9959 18774-18782 VB denotes requires
T9958 18766-18773 NN denotes targets
T9957 18762-18765 PRP-DOLLAR- denotes its
T9956 18757-18761 IN denotes with
T9955 18753-18756 NN denotes A20
T9954 18750-18752 IN denotes of
T9953 18738-18749 NN denotes association
T9952 18734-18737 DT denotes The
T9951 18731-18732 -RRB- denotes ]
T9950 18729-18731 CD denotes 42
T9949 18728-18729 -LRB- denotes [
T9948 18717-18727 NN denotes signalling
T9947 18711-18716 NN denotes NF-κB
T9946 18698-18710 VB denotes downregulate
T9945 18695-18697 TO denotes to
T9944 18691-18694 NN denotes A20
T9943 18688-18690 IN denotes by
T9942 18683-18687 VB denotes used
T9941 18673-18682 NN denotes mechanism
T9940 18663-18672 JJ denotes important
T9939 18655-18662 DT denotes another
T9938 18652-18654 IN denotes as
T9937 18642-18651 VB denotes described
T9936 18637-18641 VB denotes were
T9935 18635-18636 -RRB- denotes )
T9934 18628-18635 NN denotes cIAP1/2
T9933 18624-18627 CC denotes and
T9932 18618-18623 NN denotes TRAF2
T9931 18616-18617 -COMMA- denotes ,
T9930 18611-18616 NN denotes TRAF6
T9929 18610-18611 -LRB- denotes (
T9928 18602-18609 NN denotes ligases
T9927 18592-18601 NN denotes ubiquitin
T9926 18589-18591 NN denotes E3
T9925 18585-18588 CC denotes and
T9924 18583-18584 -RRB- denotes )
T9923 18577-18583 NN denotes Ubc5hc
T9922 18573-18576 CC denotes and
T9921 18567-18572 NN denotes Ubc13
T9920 18566-18567 -LRB- denotes (
T9919 18558-18565 NN denotes enzymes
T9918 18546-18557 VB denotes conjugating
T9917 18536-18545 NN denotes ubiquitin
T9916 18533-18535 NN denotes E2
T9915 18525-18532 IN denotes between
T9914 18512-18524 NN denotes interactions
T9913 18509-18511 IN denotes of
T9912 18498-18508 NN denotes disruption
T9911 18494-18497 DT denotes the
T9910 18492-18493 -COMMA- denotes ,
T9909 18484-18492 RB denotes Recently
T9908 18481-18482 -RRB- denotes )
T9907 18480-18481 CD denotes 1
T9906 18473-18479 NN denotes Figure
T9905 18472-18473 -LRB- denotes (
T9904 18470-18471 -RRB- denotes ]
T9903 18465-18470 CD denotes 38-41
T9902 18464-18465 -LRB- denotes [
T9901 18451-18463 NN denotes interactions
T9900 18435-18450 JJ denotes protein-protein
T9899 18426-18434 JJ denotes specific
T9898 18417-18425 VB denotes disrupts
T9897 18411-18416 WDT denotes which
T9896 18409-18410 -COMMA- denotes ,
T9895 18404-18409 NN denotes MALT1
T9894 18400-18403 CC denotes and
T9893 18394-18399 NN denotes TRAF6
T9892 18392-18393 -COMMA- denotes ,
T9891 18388-18392 NN denotes RIP2
T9890 18386-18387 -COMMA- denotes ,
T9889 18382-18386 NN denotes RIP1
T9888 18379-18381 IN denotes as
T9887 18374-18378 JJ denotes such
T9886 18372-18373 -COMMA- denotes ,
T9885 18363-18372 NN denotes molecules
T9884 18352-18362 NN denotes signalling
T9883 18346-18351 NN denotes NF-κB
T9882 18337-18345 JJ denotes specific
T9881 18320-18336 VB denotes deubiquitinating
T9880 18317-18319 IN denotes by
T9879 18308-18316 NN denotes function
T9878 18302-18307 NN denotes NF-κB
T9877 18294-18301 VB denotes inhibit
T9876 18291-18293 TO denotes to
T9875 18282-18290 VB denotes believed
T9874 18279-18281 VB denotes is
T9873 18275-18278 NN denotes A20
T9872 18272-18273 -RRB- denotes )
T9871 18271-18272 -RRB- denotes ]
T9870 18269-18271 CD denotes 37
T9869 18268-18269 -LRB- denotes [
T9868 18265-18267 IN denotes in
T9867 18256-18264 VB denotes reviewed
T9866 18255-18256 -LRB- denotes (
T9865 18246-18254 NN denotes receptor
T9864 18244-18245 CD denotes 2
T9863 18226-18243 JJ denotes domain-containing
T9862 18210-18225 NN denotes oligomerisation
T9861 18191-18209 JJ denotes nucleotide-binding
T9860 18187-18190 DT denotes the
T9859 18183-18186 CC denotes and
T9858 18178-18182 NN denotes TLRs
T9857 18175-18177 IN denotes of
T9856 18164-18174 NN denotes triggering
T9855 18160-18163 DT denotes the
T9854 18156-18159 CC denotes and
T9853 18154-18155 -COMMA- denotes ,
T9852 18146-18154 NN denotes antigens
T9851 18142-18145 CC denotes and
T9850 18137-18141 NN denotes IL-1
T9849 18135-18136 -COMMA- denotes ,
T9848 18132-18135 NN denotes TNF
T9847 18122-18131 VB denotes including
T9846 18120-18121 -COMMA- denotes ,
T9845 18113-18120 NN denotes stimuli
T9844 18095-18112 JJ denotes immune-activating
T9843 18085-18094 JJ denotes different
T9842 18082-18084 TO denotes to
T9841 18073-18081 NN denotes response
T9840 18070-18072 IN denotes in
T9839 18059-18069 NN denotes expression
T9838 18054-18058 NN denotes gene
T9837 18038-18053 JJ denotes NF-κB-dependent
T9836 18028-18037 VB denotes regulates
T9835 18017-18027 RB denotes negatively
T9834 18012-18016 WDT denotes that
T9833 18004-18011 NN denotes protein
T9832 17986-18003 JJ denotes ubiquitin-editing
T9831 17984-17985 DT denotes a
T9830 17981-17983 VB denotes is
T9829 17979-17980 -RRB- denotes )
T9828 17972-17979 NN denotes TNFAIP3
T9827 17969-17971 IN denotes as
T9826 17963-17968 VB denotes known
T9825 17958-17962 RB denotes also
T9824 17957-17958 -LRB- denotes (
T9823 17953-17956 NN denotes A20
T9822 17945-17952 NN denotes protein
T9821 17941-17944 NN denotes A20
T10620 22858-22863 NN denotes tools
T10619 22849-22857 JJ denotes valuable
T10618 22844-22848 RB denotes very
T10617 22841-22843 VB denotes be
T10616 22836-22840 MD denotes will
T10615 22834-22835 -COMMA- denotes ,
T10614 22832-22834 NN denotes RA
T10613 22828-22831 IN denotes for
T10612 22821-22827 NN denotes models
T10611 22815-22820 NN denotes mouse
T10610 22810-22814 IN denotes with
T10609 22801-22809 VB denotes combined
T10608 22799-22800 -COMMA- denotes ,
T10607 22795-22799 NN denotes SNPs
T10606 22791-22794 NN denotes A20
T10605 22777-22790 VB denotes corresponding
T10604 22773-22776 DT denotes the
T10603 22769-22772 IN denotes for
T10602 22764-22768 NN denotes mice
T10601 22756-22763 JJ denotes knockin
T10600 22754-22755 -COMMA- denotes ,
T10599 22747-22754 NN denotes context
T10598 22742-22746 DT denotes this
T10597 22739-22741 IN denotes In
T10596 22729-22737 NN denotes variants
T10595 22723-22728 DT denotes these
T10594 22720-22722 IN denotes of
T10593 22707-22719 NN denotes consequences
T10592 22696-22706 JJ denotes functional
T10591 22692-22695 DT denotes the
T10590 22682-22691 VB denotes elucidate
T10589 22679-22681 TO denotes to
T10588 22675-22678 CC denotes and
T10587 22666-22674 NN denotes variants
T10586 22659-22665 JJ denotes causal
T8558 16778-16780 IN denotes of
T8557 16762-16777 NN denotes immunopathology
T8556 16758-16761 DT denotes the
T8555 16755-16757 IN denotes in
T8554 16747-16754 NN denotes factors
T8553 16736-16746 JJ denotes inhibitory
T8552 16730-16735 NN denotes NF-κB
T8551 16724-16729 DT denotes these
T8550 16721-16723 IN denotes of
T8549 16716-16720 NN denotes role
T8548 16706-16715 JJ denotes potential
T8547 16702-16705 DT denotes the
T8546 16694-16701 VB denotes discuss
T8545 16691-16693 PRP denotes we
T8544 16689-16690 -COMMA- denotes ,
T8543 16681-16689 NN denotes addition
T8542 16678-16680 IN denotes In
T8541 16672-16676 NN denotes loop
T8540 16663-16671 NN denotes feedback
T8539 16654-16662 JJ denotes negative
T8538 16652-16653 DT denotes a
T8537 16649-16651 IN denotes in
T8536 16642-16648 VB denotes acting
T8535 16637-16641 RB denotes thus
T8534 16633-16636 CC denotes and
T8533 16626-16632 PRP denotes itself
T8532 16620-16625 NN denotes NF-κB
T8531 16617-16619 IN denotes of
T8530 16609-16616 NN denotes control
T8529 16605-16608 DT denotes the
T8528 16599-16604 IN denotes under
T8527 16594-16598 PRP denotes them
T8526 16591-16593 IN denotes of
T8525 16586-16590 DT denotes some
T8524 16584-16585 -COMMA- denotes ,
T8523 16576-16584 NN denotes response
T8522 16570-16575 NN denotes NF-κB
T8521 16566-16569 DT denotes the
T8520 16563-16565 IN denotes of
T8519 16551-16562 NN denotes termination
T8518 16548-16550 CC denotes or
T8517 16538-16547 NN denotes dampening
T8516 16534-16537 DT denotes the
T8515 16531-16533 IN denotes in
T8514 16522-16530 VB denotes involved
T8513 16518-16521 VB denotes are
T8512 16513-16517 WDT denotes that
T8511 16504-16512 NN denotes proteins
T8510 16501-16503 IN denotes of
T8509 16494-16500 NN denotes number
T8508 16492-16493 DT denotes a
T8507 16489-16491 IN denotes of
T8506 16480-16488 NN denotes overview
T8505 16477-16479 DT denotes an
T8504 16472-16476 VB denotes give
T8503 16469-16471 PRP denotes we
T8502 16463-16468 IN denotes Below
T8501 16460-16461 -RRB- denotes ]
T8500 16458-16460 CD denotes 32
T8499 16457-16458 -LRB- denotes [
T8498 16446-16456 NN denotes signalling
T8497 16440-16445 NN denotes NF-κB
T8496 16427-16439 VB denotes downregulate
T8495 16422-16426 WDT denotes that
T8494 16413-16421 NN denotes proteins
T8493 16402-16412 JJ denotes inhibitory
T8492 16399-16401 IN denotes of
T8491 16388-16398 NN denotes expression
T8490 16384-16387 DT denotes the
T8489 16374-16383 VB denotes including
T8488 16372-16373 -COMMA- denotes ,
T8487 16362-16372 NN denotes mechanisms
T8486 16352-16361 JJ denotes different
T8485 16345-16351 VB denotes employ
T8484 16339-16344 NN denotes cells
T8483 16337-16338 -COMMA- denotes ,
T8482 16333-16337 DT denotes this
T8481 16325-16332 VB denotes achieve
T8480 16322-16324 TO denotes To
T8479 16307-16320 NN denotes tumorigenesis
T8478 16300-16306 CC denotes and/or
T8477 16287-16299 NN denotes inflammation
T8476 16279-16286 JJ denotes chronic
T8475 16276-16278 TO denotes to
T8474 16271-16275 VB denotes lead
T8473 16267-16270 MD denotes may
T8472 16262-16266 WDT denotes that
T8471 16251-16261 NN denotes activation
T8470 16245-16250 NN denotes NF-κB
T8469 16234-16244 JJ denotes persistent
T8468 16226-16233 VB denotes prevent
T8467 16223-16225 TO denotes to
T8466 16213-16222 JJ denotes essential
T8465 16210-16212 VB denotes is
T8464 16201-16209 NN denotes response
T8463 16195-16200 NN denotes NF-κB
T8462 16192-16194 DT denotes an
T8461 16180-16191 VB denotes terminating
T8460 16178-16179 -COMMA- denotes ,
T8459 16170-16178 RB denotes Moreover
T10585 22652-22658 JJ denotes actual
T10584 22648-22651 DT denotes the
T10583 22639-22647 VB denotes identify
T10582 22636-22638 TO denotes to
T10581 22627-22635 NN denotes interest
T10580 22624-22626 IN denotes of
T10579 22621-22623 VB denotes be
T10578 22616-22620 MD denotes will
T10577 22613-22615 PRP denotes It
T10576 22610-22611 -RRB- denotes ]
T10575 22608-22610 CD denotes 53
T10574 22607-22608 -LRB- denotes [
T10573 22594-22606 VB denotes investigated
T10572 22589-22593 NN denotes SNPs
T10571 22585-22588 DT denotes the
T10570 22582-22584 IN denotes of
T10569 22577-22581 DT denotes some
T10568 22573-22576 IN denotes for
T10567 22559-22572 NN denotes transcription
T10566 22555-22558 NN denotes A20
T10565 22545-22554 VB denotes repressed
T10564 22540-22544 VB denotes show
T10563 22534-22539 MD denotes could
T10562 22530-22533 CC denotes and
T10561 22528-22529 -COMMA- denotes ,
T10560 22520-22528 NN denotes activity
T10559 22511-22519 NN denotes promoter
T10558 22507-22510 NN denotes A20
T10557 22504-22506 IN denotes on
T10556 22495-22503 NN denotes variants
T10555 22491-22494 NN denotes SNP
T10554 22477-22490 JJ denotes RA-associated
T10553 22474-22476 IN denotes of
T10552 22466-22473 NN denotes ability
T10551 22455-22465 JJ denotes regulatory
T10550 22451-22454 DT denotes the
T10549 22445-22450 FW denotes vitro
T10548 22442-22444 FW denotes in
T10547 22432-22441 VB denotes evaluated
T10546 22419-22431 RB denotes functionally
T10545 22408-22418 NN denotes colleagues
T10544 22404-22407 CC denotes and
T10543 22398-22403 NNP denotes Elsby
T10542 22396-22397 -COMMA- denotes ,
T10541 22388-22396 RB denotes Recently
T10540 22379-22386 JJ denotes unclear
T10539 22372-22378 VB denotes remain
T10538 22370-22371 -COMMA- denotes ,
T10537 22363-22370 RB denotes however
T10536 22361-22362 -COMMA- denotes ,
T10535 22359-22361 NN denotes RA
T10534 22353-22358 VB denotes cause
T10533 22348-22352 PRP denotes they
T10532 22344-22347 WRB denotes how
T10531 22340-22343 CC denotes and
T10530 22331-22339 NN denotes activity
T10529 22327-22330 NN denotes A20
T10528 22320-22326 JJ denotes normal
T10527 22313-22319 VB denotes affect
T10526 22304-22312 NN denotes variants
T10525 22298-22303 DT denotes these
T10524 22294-22297 WRB denotes How
T10523 22290-22292 NN denotes RA
T10522 22286-22289 IN denotes for
T10521 22280-22285 NN denotes locus
T10520 22265-22279 NN denotes susceptibility
T10519 22255-22264 NN denotes candidate
T10518 22253-22254 DT denotes a
T10517 22250-22252 IN denotes as
T10516 22246-22249 NN denotes A20
T10515 22239-22245 VB denotes reveal
T10514 22230-22238 NN denotes findings
T10513 22224-22229 DT denotes these
T10512 22222-22223 -COMMA- denotes ,
T10511 22220-22222 NN denotes RA
T10510 22217-22219 IN denotes in
T10509 22208-22216 NN denotes cytokine
T10508 22195-22207 JJ denotes inflammatory
T10507 22187-22194 JJ denotes primary
T10506 22183-22186 DT denotes the
T10505 22180-22182 VB denotes is
T10504 22176-22179 NN denotes TNF
T10503 22172-22175 CC denotes and
T10502 22170-22171 -COMMA- denotes ,
T10501 22163-22170 NN denotes signals
T10500 22151-22162 JJ denotes TNF-induced
T10499 22148-22150 IN denotes of
T10498 22136-22147 NN denotes termination
T10497 22132-22135 IN denotes for
T10496 22123-22131 VB denotes required
T10495 22120-22122 VB denotes is
T10494 22116-22119 NN denotes A20
T10493 22113-22115 IN denotes As
T10492 22105-22111 NN denotes region
T10491 22100-22104 DT denotes this
T10490 22097-22099 IN denotes in
T10489 22088-22096 NN denotes elements
T10488 22084-22087 NN denotes DNA
T10487 22073-22083 JJ denotes regulatory
T10486 22063-22072 JJ denotes potential
T10485 22060-22062 IN denotes of
T10484 22051-22059 NN denotes presence
T10483 22047-22050 DT denotes the
T10482 22044-22046 IN denotes by
T10481 22035-22043 RB denotes probably
T10480 22033-22034 -COMMA- denotes ,
T10479 22032-22033 -RRB- denotes )
T10478 22029-22032 NN denotes A20
T10477 22026-22028 IN denotes of
T10476 22015-22025 RB denotes downstream
T10475 22012-22014 NN denotes kb
T10474 22007-22011 CD denotes ~150
T10473 22006-22007 -LRB- denotes (
T10472 22001-22005 NN denotes gene
T10471 21993-22000 JJ denotes nearest
T10470 21989-21992 PRP-DOLLAR- denotes its
T10469 21986-21988 IN denotes as
T10468 21982-21985 NN denotes A20
T10467 21972-21981 VB denotes influence
T10466 21969-21971 TO denotes to
T10465 21961-21968 VB denotes thought
T10464 21957-21960 VB denotes are
T10463 21952-21956 PRP denotes they
T10462 21950-21951 -COMMA- denotes ,
T10025 19191-19194 CC denotes and
T10024 19178-19190 NN denotes inflammation
T10023 19167-19177 JJ denotes multiorgan
T10022 19159-19166 VB denotes develop
T10021 19145-19158 RB denotes spontaneously
T10020 19140-19144 NN denotes mice
T10019 19126-19139 JJ denotes A20-deficient
T10018 19117-19124 JJ denotes elusive
T10017 19111-19116 RB denotes still
T10016 19107-19110 VB denotes are
T10015 19105-19106 -COMMA- denotes ,
T10014 19098-19105 RB denotes however
T10013 19096-19097 -COMMA- denotes ,
T10012 19086-19096 NN denotes signalling
T10011 19076-19085 JJ denotes apoptotic
T10010 19066-19075 VB denotes regulates
T10009 19062-19065 NN denotes A20
T10008 19056-19061 WDT denotes which
T10007 19053-19055 IN denotes by
T10006 19042-19052 NN denotes mechanisms
T10005 19038-19041 DT denotes The
T10004 19031-19036 NN denotes types
T10003 19026-19030 NN denotes cell
T10002 19021-19025 DT denotes some
T10001 19018-19020 IN denotes in
T10000 19012-19017 JJ denotes least
T9999 19009-19011 IN denotes at
T9998 19007-19008 -COMMA- denotes ,
T9997 18998-19007 NN denotes apoptosis
T9996 18995-18997 IN denotes of
T9995 18985-18994 NN denotes inhibitor
T9994 18978-18984 JJ denotes strong
T9993 18976-18977 DT denotes a
T9992 18971-18975 RB denotes also
T9991 18968-18970 VB denotes is
T9990 18964-18967 NN denotes A20
T9989 18962-18963 -COMMA- denotes ,
T9988 18952-18962 NN denotes activation
T9987 18946-18951 NN denotes NF-κB
T9986 18934-18945 VB denotes suppressing
T9985 18931-18933 IN denotes in
T9984 18926-18930 NN denotes role
T9983 18922-18925 PRP-DOLLAR- denotes its
T9982 18919-18921 TO denotes to
T9981 18914-18918 JJ denotes Next
T9980 18911-18912 -RRB- denotes ]
T9979 18906-18911 CD denotes 43-46
T9978 18905-18906 -LRB- denotes [
T9977 18903-18904 CD denotes 1
T8458 16160-16168 NN denotes response
T8457 16147-16159 JJ denotes inflammatory
T8456 16143-16146 DT denotes the
T8455 16133-16142 VB denotes fine-tune
T8454 16130-16132 TO denotes to
T8453 16118-16129 NN denotes requirement
T8452 16109-16117 JJ denotes absolute
T8451 16106-16108 DT denotes an
T8450 16103-16105 VB denotes is
T8449 16095-16102 VB denotes induces
T8448 16092-16094 PRP denotes it
T8447 16086-16091 NN denotes genes
T8446 16082-16085 DT denotes the
T8445 16078-16081 CC denotes and
T8444 16070-16077 NN denotes pathway
T8443 16059-16069 NN denotes signalling
T8442 16053-16058 NN denotes NF-κB
T8441 16049-16052 DT denotes the
T8440 16046-16048 IN denotes of
T8439 16035-16045 NN denotes regulation
T8438 16029-16034 JJ denotes tight
T8437 16027-16028 DT denotes a
T8436 16025-16026 -COMMA- denotes ,
T8435 16016-16025 NN denotes processes
T8434 16007-16015 JJ denotes cellular
T8433 16002-16006 JJ denotes many
T8432 15999-16001 TO denotes to
T8431 15991-15998 JJ denotes crucial
T8430 15988-15990 RB denotes so
T8429 15985-15987 VB denotes is
T8428 15974-15984 NN denotes activation
T8427 15968-15973 NN denotes NF-κB
T8426 15962-15967 IN denotes Since
T10461 21946-21950 NN denotes gene
T10460 21944-21945 DT denotes a
T10459 21941-21943 IN denotes in
T10458 21933-21940 VB denotes located
T10457 21929-21932 RB denotes not
T10456 21925-21928 VB denotes are
T10455 21916-21924 NN denotes variants
T10454 21905-21915 VB denotes identified
T10453 21901-21904 DT denotes the
T10452 21892-21900 IN denotes Although
T10451 21889-21890 -RRB- denotes ]
T10450 21887-21889 CD denotes 52
T10449 21886-21887 -LRB- denotes [
T10448 21883-21885 NN denotes RA
T10447 21880-21882 TO denotes to
T10446 21865-21879 NN denotes susceptibility
T10445 21861-21864 CC denotes and
T10444 21850-21860 NN denotes chromosome
T10037 19254-19260 JJ denotes potent
T10036 19250-19253 DT denotes the
T10035 19237-19249 VB denotes illustrating
T10034 19235-19236 -COMMA- denotes ,
T10033 19230-19235 NN denotes birth
T10032 19227-19229 IN denotes of
T10031 19221-19226 NN denotes weeks
T10030 19219-19220 CD denotes 2
T10029 19212-19218 IN denotes within
T10028 19208-19211 VB denotes die
T10027 19204-19207 CC denotes and
T10026 19195-19203 NN denotes cachexia
T8741 17936-17938 NN denotes RA
T8740 17931-17935 IN denotes like
T8739 17922-17930 NN denotes diseases
T8738 17909-17921 JJ denotes inflammatory
T8737 17901-17908 JJ denotes chronic
T8736 17897-17900 IN denotes for
T8735 17884-17896 NN denotes implications
T8734 17875-17883 JJ denotes possible
T8733 17870-17874 IN denotes with
T8732 17861-17869 NN denotes pathways
T8731 17855-17860 NN denotes NF-κB
T8730 17842-17854 JJ denotes noncanonical
T8729 17838-17841 CC denotes and
T8728 17828-17837 JJ denotes canonical
T8727 17823-17827 CC denotes both
T8726 17811-17822 VB denotes terminating
T8725 17808-17810 IN denotes in
T8724 17802-17807 NN denotes roles
T8723 17792-17801 JJ denotes important
T8722 17786-17791 VB denotes plays
T8721 17781-17785 NN denotes IKK1
T8720 17776-17780 IN denotes that
T8719 17771-17775 NN denotes idea
T8718 17767-17770 DT denotes the
T8717 17756-17766 VB denotes supporting
T8716 17754-17755 -COMMA- denotes ,
T8715 17753-17754 -RRB- denotes ]
T8714 17751-17753 CD denotes 36
T8713 17750-17751 -LRB- denotes [
T8712 17742-17749 NN denotes pathway
T8711 17736-17741 NN denotes NF-κB
T8710 17723-17735 JJ denotes noncanonical
T8709 17719-17722 DT denotes the
T8708 17716-17718 IN denotes of
T8707 17705-17715 NN denotes regulation
T8706 17696-17704 NN denotes feedback
T8705 17687-17695 JJ denotes negative
T8704 17684-17686 IN denotes in
T8703 17680-17683 NN denotes NIK
T8702 17665-17679 VB denotes phosphorylates
T8701 17660-17664 NN denotes IKK1
T8700 17655-17659 IN denotes that
T8699 17642-17654 VB denotes demonstrated
T8698 17638-17641 VB denotes has
T8697 17632-17637 NN denotes study
T8696 17625-17631 JJ denotes recent
T8695 17623-17624 DT denotes a
T8694 17621-17622 -COMMA- denotes ,
T8693 17608-17621 RB denotes Interestingly
T8692 17605-17606 -RRB- denotes ]
T8691 17603-17605 CD denotes 35
T8690 17602-17603 -LRB- denotes [
T8689 17596-17601 NN denotes STAT1
T8688 17580-17595 VB denotes phosphorylating
T8687 17577-17579 IN denotes by
T8686 17566-17576 NN denotes signalling
T8685 17550-17565 JJ denotes proinflammatory
T8684 17537-17549 VB denotes downregulate
T8683 17534-17536 TO denotes to
T8682 17530-17533 CC denotes and
T8681 17524-17529 NN denotes NF-κB
T8680 17516-17523 JJ denotes nuclear
T8679 17508-17515 VB denotes inhibit
T8678 17505-17507 TO denotes to
T8677 17499-17504 VB denotes shown
T8676 17494-17498 VB denotes been
T8675 17489-17493 RB denotes also
T8674 17485-17488 VB denotes has
T8673 17480-17484 NN denotes IKK1
T8672 17477-17478 -RRB- denotes ]
T8671 17475-17477 CD denotes 34
T8670 17474-17475 -LRB- denotes [
T8669 17462-17473 NN denotes degradation
T8668 17457-17461 NN denotes IκBα
T8667 17453-17456 CC denotes and
T8666 17442-17452 NN denotes activation
T8665 17437-17441 NN denotes IKK2
T8664 17428-17436 VB denotes enhanced
T8663 17425-17427 IN denotes of
T8662 17418-17424 NN denotes result
T8661 17416-17417 DT denotes a
T8660 17413-17415 IN denotes as
T8659 17403-17412 NN denotes cytokines
T8658 17387-17402 JJ denotes proinflammatory
T8657 17384-17386 IN denotes of
T8656 17373-17383 NN denotes production
T8655 17363-17372 VB denotes increased
T8654 17358-17362 VB denotes show
T8653 17353-17357 NN denotes IKK1
T8652 17344-17352 JJ denotes inactive
T8651 17333-17343 VB denotes expressing
T8650 17328-17332 NN denotes mice
T8649 17320-17327 JJ denotes knockin
T8648 17317-17319 CC denotes or
T8647 17312-17316 NN denotes mice
T8646 17297-17311 JJ denotes IKK1-deficient
T8645 17292-17296 IN denotes from
T8644 17280-17291 NN denotes Macrophages
T8643 17270-17278 NN denotes pathways
T8642 17264-17269 NN denotes NF-κB
T8641 17251-17263 JJ denotes noncanonical
T8640 17247-17250 CC denotes and
T8639 17237-17246 JJ denotes canonical
T8638 17232-17236 CC denotes both
T8637 17229-17231 IN denotes of
T8636 17218-17228 NN denotes regulation
T8635 17209-17217 JJ denotes negative
T8634 17205-17208 DT denotes the
T8633 17202-17204 IN denotes in
T8632 17197-17201 NN denotes role
T8631 17187-17196 JJ denotes prominent
T8630 17185-17186 DT denotes a
T8629 17179-17184 VB denotes plays
T8628 17174-17178 RB denotes also
T8627 17167-17173 NN denotes kinase
T8626 17162-17166 DT denotes this
T8625 17157-17161 IN denotes that
T8624 17147-17156 VB denotes mentioned
T8623 17144-17146 VB denotes be
T8622 17137-17143 MD denotes should
T8621 17134-17136 PRP denotes it
T8620 17132-17133 -COMMA- denotes ,
T8619 17125-17132 NN denotes pathway
T8618 17119-17124 NN denotes NF-κB
T8617 17105-17118 JJ denotes non-canonical
T8616 17101-17104 DT denotes the
T8615 17098-17100 IN denotes of
T8614 17088-17097 NN denotes component
T8613 17079-17087 JJ denotes critical
T8612 17077-17078 DT denotes a
T8611 17074-17076 VB denotes is
T8610 17069-17073 NN denotes IKK1
T8609 17050-17068 IN denotes reported. Although
T8608 17045-17049 VB denotes been
T8607 17041-17044 RB denotes yet
T8606 17037-17040 RB denotes not
T8605 17033-17036 VB denotes has
T8604 17023-17032 NN denotes pathology
T8603 17020-17022 NN denotes RA
T8602 17015-17019 IN denotes with
T8601 17010-17014 NN denotes link
T8600 17008-17009 DT denotes a
T8599 17002-17007 IN denotes since
T8598 17000-17001 -COMMA- denotes ,
T8597 16996-17000 RB denotes here
T8596 16986-16995 VB denotes discussed
T8595 16982-16985 RB denotes not
T8594 16978-16981 VB denotes are
T8593 16969-16977 NN denotes proteins
T8592 16963-16968 DT denotes These
T8591 16960-16961 -RRB- denotes )
T8590 16959-16960 -RRB- denotes ]
T8589 16957-16959 CD denotes 33
T8588 16956-16957 -LRB- denotes [
T8587 16953-16955 IN denotes in
T8586 16944-16952 VB denotes reviewed
T8585 16943-16944 -LRB- denotes (
T8584 16933-16942 VB denotes described
T8583 16928-16932 VB denotes been
T8582 16923-16927 VB denotes have
T8581 16921-16922 -COMMA- denotes ,
T8580 16915-16921 NN denotes TOLLIP
T8579 16911-16914 CC denotes and
T8578 16909-16910 -COMMA- denotes ,
T8577 16903-16909 NN denotes IRAK-M
T8576 16901-16902 -COMMA- denotes ,
T8575 16895-16901 NN denotes MyD88s
T8574 16892-16894 IN denotes as
T8573 16887-16891 JJ denotes such
T8572 16885-16886 -COMMA- denotes ,
T8571 16876-16885 NN denotes responses
T8570 16863-16875 JJ denotes inflammatory
T8569 16847-16862 JJ denotes NF-κB-dependent
T8568 16844-16846 IN denotes of
T8567 16833-16843 NN denotes regulation
T8566 16824-16832 JJ denotes negative
T8565 16820-16823 DT denotes the
T8564 16817-16819 IN denotes in
T8563 16808-16816 VB denotes involved
T8562 16799-16807 NN denotes proteins
T8561 16793-16798 JJ denotes other
T8560 16785-16792 JJ denotes Several
T8559 16781-16783 NN denotes RA
T5414 15456-15461 VB denotes leads
T5413 15451-15455 DT denotes this
T5412 15447-15450 CC denotes and
T5411 15445-15446 -COMMA- denotes ,
T5410 15440-15445 NN denotes TRAF6
T5409 15436-15439 CC denotes and
T5408 15434-15435 -COMMA- denotes ,
T5407 15429-15434 NN denotes TRAF5
T5406 15427-15428 -COMMA- denotes ,
T5405 15422-15427 NN denotes TRAF3
T5404 15420-15421 -COMMA- denotes ,
T5403 15415-15420 NN denotes TRAF2
T5402 15413-15414 -COMMA- denotes ,
T5401 15408-15413 NN denotes TRAF1
T5400 15398-15407 VB denotes including
T5399 15396-15397 -COMMA- denotes ,
T5398 15389-15396 NN denotes members
T5397 15384-15388 NN denotes TRAF
T5396 15376-15383 JJ denotes several
T5395 15371-15375 IN denotes with
T5394 15362-15370 VB denotes interact
T5393 15357-15361 NN denotes RANK
T5392 15353-15356 CC denotes and
T5391 15348-15352 NN denotes CD40
T5390 15346-15347 -COMMA- denotes ,
T5389 15340-15346 NN denotes ligand
T5388 15334-15339 PRP-DOLLAR- denotes their
T5387 15331-15333 IN denotes of
T5386 15323-15330 NN denotes binding
T5385 15318-15322 IN denotes Upon
T5384 15308-15316 NN denotes pathways
T5383 15297-15307 NN denotes signalling
T5382 15291-15296 NN denotes NF-κB
T5381 15278-15290 JJ denotes noncanonical
T5380 15274-15277 CC denotes and
T5379 15264-15273 JJ denotes canonical
T5378 15259-15263 CC denotes both
T5377 15256-15258 IN denotes of
T5376 15245-15255 NN denotes activation
T5375 15241-15244 DT denotes the
T5374 15233-15240 VB denotes mediate
T5373 15228-15232 NN denotes RANK
T5372 15224-15227 CC denotes and
T5371 15215-15223 NN denotes receptor
T5370 15213-15214 NN denotes β
T5369 15201-15212 NN denotes lymphotoxin
T5368 15199-15200 -COMMA- denotes ,
T5367 15195-15199 NN denotes CD40
T5366 15190-15194 IN denotes that
T5365 15180-15189 VB denotes mentioned
T5364 15177-15179 VB denotes be
T5363 15170-15176 MD denotes should
T5362 15167-15169 PRP denotes It
T5361 13836-13837 -RRB- denotes )
T5360 13835-13836 CD denotes 2
T5359 13828-13834 NN denotes Figure
T5358 13827-13828 -LRB- denotes (
T5357 13825-13826 -RRB- denotes ]
T5356 13820-13825 CD denotes 28,29
T5355 13819-13820 -LRB- denotes [
T5354 13803-13818 NN denotes phosphorylation
T5353 13798-13802 NN denotes IKK1
T5352 13794-13797 CC denotes and
T5351 13781-13793 NN denotes accumulation
T5350 13777-13780 NN denotes NIK
T5349 13774-13776 IN denotes in
T5348 13764-13773 VB denotes resulting
T5347 13762-13763 -COMMA- denotes ,
T5346 13751-13762 NN denotes degradation
T5345 13738-13750 JJ denotes constitutive
T5344 13734-13737 PRP-DOLLAR- denotes its
T5343 13729-13733 IN denotes from
T5342 13725-13728 NN denotes NIK
T5341 13715-13724 VB denotes releasing
T5340 13712-13714 TO denotes to
T5339 13700-13711 VB denotes contributes
T5338 13695-13699 DT denotes this
T5337 13691-13694 PDT denotes All
T5336 13678-13689 NN denotes degradation
T5335 13672-13677 NN denotes TRAF3
T5334 13661-13671 JJ denotes subsequent
T5333 13657-13660 IN denotes for
T5332 13647-13656 JJ denotes essential
T5331 13643-13646 VB denotes are
T5330 13637-13642 WDT denotes which
T5329 13635-13636 -COMMA- denotes ,
T5328 13628-13635 NN denotes cIAP1/2
T5327 13624-13627 CC denotes and
T5326 13618-13623 NN denotes TRAF2
T5325 13610-13617 VB denotes attract
T5324 13607-13609 TO denotes to
T5323 13602-13606 RB denotes also
T5322 13598-13601 CC denotes but
T5321 13596-13597 -COMMA- denotes ,
T5320 13588-13596 NN denotes receptor
T5319 13584-13587 DT denotes the
T5318 13581-13583 TO denotes to
T5317 13578-13580 PRP denotes it
T5316 13567-13577 VB denotes recruiting
T5315 13564-13566 IN denotes by
T5314 13556-13563 NN denotes complex
T5313 13551-13555 DT denotes this
T5312 13546-13550 IN denotes from
T5311 13540-13545 NN denotes TRAF3
T5310 13533-13539 VB denotes remove
T5309 13530-13532 TO denotes to
T5308 13525-13529 RB denotes only
T5307 13521-13524 RB denotes not
T5306 13515-13520 VB denotes shown
T5305 13510-13514 VB denotes been
T5304 13506-13509 VB denotes has
T5303 13497-13505 NN denotes ligation
T5302 13488-13496 NN denotes Receptor
T5301 13476-13486 NN denotes proteasome
T5300 13472-13475 DT denotes the
T5299 13469-13471 IN denotes by
T5298 13457-13468 NN denotes degradation
T5297 13446-13456 JJ denotes continuous
T5296 13442-13445 PRP-DOLLAR- denotes its
T5295 13439-13441 TO denotes to
T5294 13431-13438 VB denotes leading
T5293 13429-13430 -COMMA- denotes ,
T5292 13426-13429 NN denotes NIK
T5291 13404-13425 VB denotes K48-polyubiquitinates
T5290 13398-13403 WDT denotes which
T5289 13396-13397 -COMMA- denotes ,
T5288 13389-13396 NN denotes cIAP1/2
T5287 13385-13388 CC denotes and
T5286 13383-13384 -COMMA- denotes ,
T5285 13378-13383 NN denotes TRAF3
T5284 13376-13377 -COMMA- denotes ,
T5283 13371-13376 NN denotes TRAF2
T5282 13366-13370 IN denotes with
T5281 13358-13365 NN denotes complex
T5280 13346-13357 JJ denotes cytoplasmic
T5279 13344-13345 DT denotes a
T5278 13341-13343 IN denotes in
T5277 13334-13340 VB denotes occurs
T5276 13330-13333 NN denotes NIK
T5275 13328-13329 -COMMA- denotes ,
T5274 13323-13328 NN denotes cells
T5273 13310-13322 JJ denotes unstimulated
T5272 13307-13309 IN denotes In
T5271 13300-13305 NN denotes types
T5270 13295-13299 NN denotes cell
T5269 13290-13294 JJ denotes most
T5268 13287-13289 IN denotes in
T5267 13280-13286 NN denotes levels
T5266 13276-13279 JJ denotes low
T5265 13266-13275 RB denotes extremely
T5264 13263-13265 IN denotes at
T5263 13255-13262 JJ denotes present
T5262 13252-13254 VB denotes is
T5261 13248-13251 CC denotes and
T5260 13242-13247 NN denotes level
T5259 13223-13241 JJ denotes post-translational
T5258 13219-13222 DT denotes the
T5257 13216-13218 IN denotes at
T5256 13206-13215 VB denotes regulated
T5255 13192-13205 RB denotes predominantly
T5254 13189-13191 VB denotes is
T5253 13185-13188 NN denotes NIK
T5252 13182-13183 -RRB- denotes )
T5251 13179-13182 NN denotes NIK
T5250 13178-13179 -LRB- denotes (
T5249 13171-13177 NN denotes kinase
T5248 13162-13170 VB denotes inducing
T5247 13156-13161 NN denotes NF-κB
T5246 13153-13155 IN denotes by
T5245 13137-13152 NN denotes phosphorylation
T5244 13132-13136 IN denotes upon
T5243 13122-13131 VB denotes activated
T5242 13119-13121 VB denotes is
T5241 13113-13118 WDT denotes which
T5240 13111-13112 -COMMA- denotes ,
T5239 13107-13111 NN denotes IKK1
T5238 13104-13106 IN denotes on
T5237 13094-13103 JJ denotes dependent
T5236 13085-13093 RB denotes strictly
T5235 13082-13084 VB denotes is
T5234 13074-13081 NN denotes pathway
T5233 13068-13073 NN denotes NF-κB
T5232 13055-13067 JJ denotes noncanonical
T5231 13051-13054 DT denotes The
T5230 13049-13050 -RRB- denotes ]
T5229 13047-13049 CD denotes 27
T5228 13046-13047 -LRB- denotes [
T5227 13027-13045 NN denotes osteoclastogenesis
T5226 13023-13026 CC denotes and
T5225 13021-13022 -COMMA- denotes ,
T5224 13010-13021 NN denotes development
T5223 13004-13009 NN denotes organ
T5222 12995-13003 JJ denotes lymphoid
T5221 12985-12994 JJ denotes secondary
T5220 12983-12984 -COMMA- denotes ,
T5219 12972-12983 NN denotes development
T5218 12965-12971 NN denotes B-cell
T5217 12957-12964 VB denotes control
T5216 12952-12956 WDT denotes that
T5215 12946-12951 NN denotes genes
T5214 12939-12945 NN denotes target
T5213 12936-12938 IN denotes of
T5212 12932-12935 NN denotes set
T5211 12923-12931 JJ denotes distinct
T5210 12921-12922 DT denotes a
T5209 12911-12920 VB denotes regulates
T5208 12903-12910 NN denotes subunit
T5207 12897-12902 NN denotes NF-κB
T5206 12892-12896 NN denotes RelB
T5205 12888-12891 DT denotes the
T5204 12883-12887 IN denotes with
T5203 12874-12882 RB denotes together
T5202 12868-12873 WDT denotes which
T5201 12866-12867 -COMMA- denotes ,
T5200 12863-12866 NN denotes p52
T5199 12860-12862 TO denotes to
T4953 11368-11375 JJ denotes unclear
T4952 11362-11367 RB denotes still
T4951 11359-11361 VB denotes is
T4950 11354-11358 DT denotes each
T4949 11351-11353 IN denotes of
T4948 11346-11350 NN denotes role
T4947 11337-11345 JJ denotes specific
T4946 11333-11336 DT denotes the
T4945 11329-11332 CC denotes but
T4944 11327-11328 -COMMA- denotes ,
T4943 11313-11327 NN denotes ubiquitination
T4942 11308-11312 NN denotes RIP1
T4941 11304-11307 IN denotes for
T4940 11293-11303 NN denotes candidates
T4939 11288-11292 JJ denotes good
T4938 11284-11287 VB denotes are
T4937 11276-11283 NN denotes cIAP1/2
T4936 11272-11275 CC denotes and
T4935 11264-11271 NN denotes TRAF2/5
T4934 11256-11262 NN denotes chains
T4933 11242-11255 NN denotes polyubiquitin
T4932 11231-11241 JJ denotes K63-linked
T4931 11228-11230 IN denotes by
T4930 11219-11227 VB denotes modified
T4929 11211-11218 RB denotes rapidly
T4928 11208-11210 VB denotes is
T4927 11203-11207 NN denotes RIP1
T4926 11197-11202 VB denotes bound
T4925 11184-11196 NN denotes TNF-receptor
T4924 11182-11183 -COMMA- denotes ,
T4923 11171-11182 NN denotes stimulation
T4922 11167-11170 NN denotes TNF
T4921 11164-11166 IN denotes On
T4920 11161-11162 -RRB- denotes )
T4919 11160-11161 CD denotes 1
T4918 11153-11159 NN denotes Figure
T4917 11152-11153 -LRB- denotes (
T4916 11146-11151 NN denotes cIAP2
T4915 11142-11145 CC denotes and
T4914 11140-11141 CD denotes 1
T4913 11138-11139 -RRB- denotes )
T4912 11134-11138 NN denotes cIAP
T4911 11133-11134 -LRB- denotes (
T4910 11123-11132 NN denotes apoptosis
T4909 11120-11122 IN denotes of
T4908 11110-11119 NN denotes inhibitor
T4907 11101-11109 JJ denotes cellular
T4906 11093-11100 NN denotes ligases
T4905 11083-11092 NN denotes ubiquitin
T4904 11080-11082 NN denotes E3
T4903 11076-11079 DT denotes the
T4902 11071-11075 VB denotes bind
T4901 11066-11070 NN denotes turn
T4900 11063-11065 IN denotes in
T4899 11057-11062 WDT denotes which
T4898 11055-11056 -COMMA- denotes ,
T4897 11050-11055 NN denotes TRAF5
T4896 11046-11049 CC denotes and
T4895 11044-11045 CD denotes 2
T4894 11042-11043 -RRB- denotes )
T4893 11038-11042 NN denotes TRAF
T4892 11037-11038 -LRB- denotes (
T4891 11030-11036 NN denotes factor
T4890 11010-11029 JJ denotes receptor-associated
T4889 11006-11009 NN denotes TNF
T4888 10998-11005 NN denotes ligases
T4887 10988-10997 NN denotes ubiquitin
T4886 10985-10987 NN denotes E3
T4885 10981-10984 DT denotes the
T4884 10977-10980 IN denotes for
T4883 10968-10976 NN denotes proteins
T4882 10960-10967 NN denotes adaptor
T4881 10957-10959 IN denotes as
T4880 10948-10956 VB denotes function
T4879 10942-10947 WDT denotes which
T4878 10940-10941 -COMMA- denotes ,
T4877 10939-10940 -RRB- denotes )
T4876 10935-10939 NN denotes RIP1
T4875 10934-10935 -LRB- denotes (
T4874 10932-10933 CD denotes 1
T4873 10924-10931 NN denotes protein
T4872 10912-10923 VB denotes interacting
T4871 10903-10911 NN denotes receptor
T4870 10900-10902 IN denotes of
T4869 10896-10899 CC denotes and
T4868 10888-10895 NN denotes protein
T4867 10886-10887 -RRB- denotes )
T4866 10881-10886 NN denotes TRADD
T4865 10880-10881 -LRB- denotes (
T4864 10873-10879 NN denotes domain
T4863 10867-10872 NN denotes death
T4862 10845-10866 JJ denotes receptor-1-associated
T4861 10841-10844 NN denotes TNF
T4860 10838-10840 IN denotes of
T4859 10826-10837 NN denotes recruitment
T4858 10822-10825 DT denotes the
T4857 10819-10821 IN denotes in
T4856 10811-10818 VB denotes results
T4855 10799-10810 NN denotes stimulation
T4854 10795-10798 NN denotes TNF
T5488 15912-15913 -RRB- denotes ]
T5487 15907-15912 CD denotes 30,31
T5486 15906-15907 -LRB- denotes [
T5485 15895-15905 NN denotes signalling
T5484 15890-15894 NN denotes CD40
T5483 15887-15889 IN denotes of
T5482 15877-15886 NN denotes regulator
T5481 15868-15876 JJ denotes negative
T5480 15866-15867 DT denotes a
T5479 15863-15865 IN denotes as
T5478 15856-15862 VB denotes serves
T5477 15850-15855 NN denotes TRAF3
T5476 15846-15849 CC denotes and
T5475 15844-15845 -COMMA- denotes ,
T5474 15839-15844 NN denotes NF-κB
T5473 15836-15838 IN denotes of
T5472 15825-15835 NN denotes activation
T5471 15821-15824 IN denotes for
T5470 15812-15820 VB denotes required
T5469 15809-15811 VB denotes is
T5468 15803-15808 NN denotes TRAF2
T5467 15797-15802 IN denotes while
T5466 15795-15796 -COMMA- denotes ,
T5465 15785-15795 NN denotes production
T5464 15780-15784 NN denotes IL-6
T5463 15776-15779 CC denotes and
T5462 15765-15775 NN denotes activation
T5461 15761-15764 NN denotes JNK
T5460 15747-15760 JJ denotes CD40-mediated
T5459 15743-15746 IN denotes for
T5458 15734-15742 VB denotes required
T5457 15731-15733 VB denotes is
T5456 15725-15730 NN denotes TRAF6
T5455 15719-15724 NN denotes cells
T5454 15717-15718 NN denotes B
T5453 15714-15716 IN denotes in
T5452 15712-15713 -COMMA- denotes ,
T5451 15705-15712 NN denotes example
T5450 15701-15704 IN denotes For
T5449 15690-15699 NN denotes functions
T5448 15676-15689 JJ denotes CD40-mediated
T5447 15667-15675 JJ denotes distinct
T5446 15663-15666 CC denotes and
T5445 15651-15662 VB denotes overlapping
T5444 15646-15650 IN denotes with
T5443 15635-15645 VB denotes associated
T5442 15631-15634 VB denotes are
T5441 15621-15630 NN denotes molecules
T5440 15616-15620 NN denotes TRAF
T5439 15607-15615 JJ denotes Specific
T5438 15600-15605 RB denotes above
T5437 15590-15599 VB denotes described
T5436 15587-15589 IN denotes as
T5435 15579-15586 NN denotes pathway
T5434 15566-15578 JJ denotes noncanonical
T5433 15562-15565 DT denotes the
T5432 15559-15561 IN denotes of
T5431 15548-15558 NN denotes activation
T5430 15544-15547 DT denotes the
T5429 15541-15543 IN denotes in
T5428 15536-15540 NN denotes step
T5427 15526-15535 JJ denotes important
T5426 15523-15525 DT denotes an
T5425 15512-15522 VB denotes represents
T5424 15506-15511 WDT denotes which
T5423 15504-15505 -COMMA- denotes ,
T5422 15499-15504 NN denotes TRAF3
T5421 15495-15498 CC denotes and
T5420 15489-15494 NN denotes TRAF2
T5419 15484-15488 CC denotes both
T5418 15481-15483 IN denotes of
T5417 15469-15480 NN denotes proteolysis
T5416 15465-15468 DT denotes the
T5415 15462-15464 TO denotes to
T4853 10786-10793 NN denotes pathway
T4852 10782-10785 NN denotes TNF
T4851 10778-10781 DT denotes the
T4850 10775-10777 VB denotes is
T4849 10766-10774 NN denotes pathways
T4848 10755-10765 NN denotes signalling
T4847 10749-10754 NN denotes NF-κB
T4846 10741-10748 VB denotes studied
T4845 10736-10740 JJ denotes best
T4844 10732-10735 DT denotes the
T4843 10729-10731 IN denotes of
T4842 10725-10728 CD denotes One
T4841 8527-8528 -RRB- denotes ]
T4840 8525-8527 CD denotes 21
T4839 8524-8525 -LRB- denotes [
T4838 8513-8523 NN denotes activation
T4837 8507-8512 NN denotes NF-κB
T4836 8497-8506 JJ denotes canonical
T4835 8493-8496 IN denotes for
T4834 8484-8492 VB denotes required
T4833 8480-8483 VB denotes are
T4832 8478-8479 -COMMA- denotes ,
T4831 8474-8478 NN denotes IKK1
T4830 8470-8473 RB denotes not
T4829 8466-8469 CC denotes but
T4828 8464-8465 -COMMA- denotes ,
T4827 8460-8464 NN denotes NEMO
T4826 8456-8459 CC denotes and
T4825 8451-8455 NN denotes IKK2
T4824 8446-8450 IN denotes that
T4823 8439-8445 VB denotes showed
T4822 8427-8438 NN denotes experiments
T4821 8417-8426 VB denotes targeting
T4820 8412-8416 NN denotes Gene
T4819 8409-8410 -RRB- denotes )
T4818 8408-8409 CD denotes 1
T4817 8401-8407 NN denotes Figure
T4816 8400-8401 -LRB- denotes (
T4815 8398-8399 -RRB- denotes )
T4814 8394-8398 NN denotes IKKγ
T4813 8391-8393 IN denotes as
T4812 8385-8390 VB denotes known
T4811 8380-8384 RB denotes also
T4810 8378-8379 -COLON- denotes -
T4809 8373-8377 NN denotes NEMO
T4808 8372-8373 -LRB- denotes (
T4807 8362-8371 NN denotes modulator
T4806 8352-8361 JJ denotes essential
T4805 8346-8351 NN denotes NF-κB
T4804 8338-8345 NN denotes subunit
T4803 8327-8337 JJ denotes regulatory
T4802 8323-8326 DT denotes the
T4801 8319-8322 CC denotes and
T4800 8317-8318 -RRB- denotes )
T4799 8313-8317 NN denotes IKKβ
T4798 8309-8312 CC denotes and
T4797 8304-8308 NN denotes IKKα
T4796 8301-8303 IN denotes as
T4795 8295-8300 VB denotes known
T4794 8290-8294 RB denotes also
T4793 8289-8290 -LRB- denotes (
T4792 8284-8288 NN denotes IKK2
T4791 8280-8283 CC denotes and
T4790 8275-8279 NN denotes IKK1
T4789 8266-8274 NN denotes subunits
T4788 8256-8265 JJ denotes catalytic
T4787 8252-8255 CD denotes two
T4786 8248-8251 DT denotes the
T4785 8245-8247 IN denotes of
T4784 8235-8244 VB denotes comprised
T4783 8232-8234 VB denotes is
T4782 8224-8231 NN denotes complex
T4781 8220-8223 NN denotes IKK
T4780 8216-8219 DT denotes The
T4779 8213-8214 -RRB- denotes ]
T4778 8211-8213 CD denotes 20
T4777 8210-8211 -LRB- denotes [
T4776 8199-8209 NN denotes proteasome
T4775 8195-8198 DT denotes the
T4774 8192-8194 IN denotes by
T4773 8180-8191 NN denotes degradation
T4772 8176-8179 CC denotes and
T4771 8153-8175 NN denotes K48-polyubiquitination
T4770 8149-8152 PRP-DOLLAR- denotes its
T4769 8146-8148 TO denotes to
T4768 8138-8145 VB denotes leading
T4767 8130-8137 NN denotes protein
T4766 8126-8129 NN denotes IκB
T4765 8115-8125 JJ denotes inhibitory
T4764 8111-8114 DT denotes the
T4763 8108-8110 IN denotes of
T4762 8092-8107 NN denotes phosphorylation
T4761 8083-8091 VB denotes mediates
T4760 8077-8082 WDT denotes which
T4759 8075-8076 -COMMA- denotes ,
T4758 8068-8075 NN denotes complex
T4757 8066-8067 -RRB- denotes )
T4756 8063-8066 NN denotes IKK
T4755 8062-8063 -LRB- denotes (
T4754 8055-8061 NN denotes kinase
T4753 8051-8054 NN denotes IκB
T4752 8047-8050 DT denotes the
T4751 8044-8046 IN denotes of
T4750 8033-8043 NN denotes activation
T4749 8029-8032 DT denotes the
T4748 8026-8028 IN denotes in
T4747 8017-8025 VB denotes converge
T4746 8006-8016 RB denotes ultimately
T4745 8002-8005 CC denotes but
T4744 8000-8001 -COMMA- denotes ,
T4743 7992-8000 JJ denotes specific
T4742 7983-7991 NN denotes receptor
T4741 7977-7982 RB denotes often
T4740 7973-7976 VB denotes are
T4739 7968-7972 WDT denotes that
T4738 7955-7967 NN denotes interactions
T4655 7455-7465 NN denotes precursors
T4654 7451-7454 VB denotes are
T4653 7446-7450 NN denotes p105
T4652 7442-7445 CC denotes and
T4651 7437-7441 NN denotes p100
T4650 7428-7436 NN denotes nucleus.
T4649 7424-7427 DT denotes the
T4648 7421-7423 IN denotes in
T4647 7405-7420 NN denotes transactivation
T4646 7399-7404 NN denotes NF-κB
T4645 7388-7398 VB denotes potentiate
T4644 7380-7387 RB denotes instead
T4643 7374-7379 NN denotes Bcl-3
T4642 7370-7373 CC denotes and
T4641 7365-7369 NN denotes IκBξ
T4640 7363-7364 -COMMA- denotes ,
T4639 7358-7363 NN denotes NF-κB
T4638 7355-7357 IN denotes of
T4637 7344-7354 NN denotes inhibitors
T4636 7341-7343 IN denotes as
T4635 7335-7340 VB denotes serve
T4634 7333-7334 -RRB- denotes )
T4633 7332-7333 -RRB- denotes )
T4632 7326-7332 NN denotes NF-κB2
T4631 7323-7325 IN denotes as
T4630 7317-7322 VB denotes known
T4629 7312-7316 RB denotes also
T4628 7311-7312 -LRB- denotes (
T4627 7306-7310 NN denotes p100
T4626 7304-7305 -COMMA- denotes ,
T4625 7303-7304 -RRB- denotes )
T4624 7297-7303 NN denotes NF-κB1
T4623 7294-7296 IN denotes as
T4622 7288-7293 VB denotes known
T4621 7283-7287 RB denotes also
T4620 7282-7283 -LRB- denotes (
T4619 7277-7281 NN denotes p105
T4618 7275-7276 -COMMA- denotes ,
T4617 7271-7275 NN denotes IκBε
T4616 7269-7270 -COMMA- denotes ,
T4615 7265-7269 NN denotes IκBβ
T4614 7263-7264 -COMMA- denotes ,
T4613 7259-7263 NN denotes IκBα
T4612 7258-7259 -LRB- denotes (
T4611 7253-7257 NN denotes IκBs
T4610 7250-7252 IN denotes of
T4609 7241-7249 NN denotes majority
T4608 7237-7240 DT denotes the
T4607 7229-7236 IN denotes Whereas
T4606 7226-7227 -RRB- denotes ]
T4605 7224-7226 CD denotes 19
T4604 7223-7224 -LRB- denotes [
T4603 7215-7222 NN denotes binding
T4602 7211-7214 NN denotes DNA
T4601 7207-7210 CC denotes and
T4600 7193-7206 NN denotes translocation
T4599 7185-7192 JJ denotes nuclear
T4598 7179-7184 NN denotes NF-κB
T4597 7171-7178 VB denotes prevent
T4596 7165-7170 WDT denotes which
T4595 7163-7164 -COMMA- denotes ,
T4594 7155-7163 NN denotes proteins
T4593 7153-7154 -RRB- denotes )
T4592 7150-7153 NN denotes IκB
T4591 7149-7150 -LRB- denotes (
T4590 7143-7148 NN denotes NF-κB
T4589 7140-7142 IN denotes of
T4588 7130-7139 NN denotes inhibitor
T4587 7127-7129 IN denotes as
T4586 7124-7126 TO denotes to
T4585 7115-7123 VB denotes referred
T4584 7106-7114 NN denotes proteins
T4583 7095-7105 JJ denotes inhibitory
T4582 7092-7094 IN denotes by
T4581 7082-7091 NN denotes complexes
T4580 7075-7081 JJ denotes latent
T4579 7072-7074 IN denotes as
T4578 7062-7071 NN denotes cytoplasm
T4577 7058-7061 DT denotes the
T4576 7055-7057 IN denotes in
T4575 7043-7054 VB denotes sequestered
T4574 7039-7042 VB denotes are
T4573 7030-7038 NN denotes proteins
T4572 7024-7029 NN denotes NF-κB
T5143 12549-12555 JJ denotes direct
T5142 12547-12548 DT denotes a
T5141 12543-12546 IN denotes via
T5140 12541-12542 -RRB- denotes ]
T5139 12539-12541 CD denotes 26
T5138 12538-12539 -LRB- denotes [
T5137 12533-12537 NN denotes RIP1
T5136 12529-12532 CC denotes and
T5135 12527-12528 -RRB- denotes ]
T5134 12525-12527 CD denotes 25
T5133 12524-12525 -LRB- denotes [
T5132 12518-12523 NN denotes TRAF6
T5131 12509-12517 VB denotes recruits
T5130 12504-12508 RB denotes also
T5129 12499-12503 NN denotes TRIF
T5128 12496-12497 -RRB- denotes ]
T5127 12494-12496 CD denotes 24
T5126 12493-12494 -LRB- denotes [
T5125 12487-12492 NN denotes TRAF6
T5124 12484-12486 IN denotes of
T5123 12465-12483 NN denotes selfubiquitination
T5122 12461-12464 CC denotes and
T5121 12445-12460 NN denotes oligomerisation
T5120 12442-12444 TO denotes to
T5119 12434-12441 VB denotes leading
T5118 12432-12433 -COMMA- denotes ,
T5117 12427-12432 NN denotes TRAF6
T5116 12423-12426 CC denotes and
T5115 12416-12422 NN denotes family
T5114 12414-12415 -RRB- denotes )
T5113 12410-12414 NN denotes IRAK
T5112 12409-12410 -LRB- denotes (
T5111 12402-12408 NN denotes kinase
T5110 12385-12401 JJ denotes IL-1R-associated
T5109 12381-12384 DT denotes the
T5108 12378-12380 IN denotes of
T5107 12370-12377 NN denotes members
T5106 12361-12369 VB denotes recruits
T5105 12356-12360 NN denotes turn
T5104 12353-12355 IN denotes in
T5103 12347-12352 NN denotes MyD88
T5102 12333-12345 RB denotes respectively
T5101 12331-12332 -COMMA- denotes ,
T5100 12330-12331 -RRB- denotes )
T5099 12326-12330 NN denotes TRIF
T5098 12325-12326 -LRB- denotes (
T5097 12320-12324 NN denotes IFNβ
T5096 12303-12319 JJ denotes adaptor-inducing
T5095 12285-12302 JJ denotes domain-containing
T5094 12281-12284 NN denotes TIR
T5093 12277-12280 CC denotes and
T5092 12275-12276 -RRB- denotes )
T5091 12270-12275 NN denotes MyD88
T5090 12269-12270 -LRB- denotes (
T5089 12266-12268 CD denotes 88
T5088 12261-12265 NN denotes gene
T5087 12252-12260 NN denotes response
T5086 12244-12251 JJ denotes primary
T5085 12228-12243 NN denotes differentiation
T5084 12220-12227 JJ denotes myeloid
T5083 12212-12219 VB denotes recruit
T5082 12209-12211 TO denotes to
T5081 12201-12208 NN denotes factors
T5080 12192-12200 VB denotes bridging
T5079 12189-12191 IN denotes as
T5078 12183-12188 VB denotes serve
T5077 12174-12182 RB denotes probably
T5076 12169-12173 RB denotes most
T5075 12163-12168 WDT denotes which
T5074 12161-12162 -COMMA- denotes ,
T5073 12160-12161 -RRB- denotes )
T5072 12156-12160 NN denotes TRAM
T5071 12155-12156 -LRB- denotes (
T5070 12146-12154 NN denotes molecule
T5069 12138-12145 NN denotes adaptor
T5068 12125-12137 JJ denotes TRIF-related
T5067 12121-12124 CC denotes and
T5066 12119-12120 -RRB- denotes )
T5065 12116-12119 NNP denotes Mal
T5064 12113-12115 IN denotes as
T5063 12110-12112 TO denotes to
T5062 12101-12109 VB denotes referred
T5061 12096-12100 RB denotes also
T5060 12095-12096 -LRB- denotes (
T5059 12087-12094 NN denotes protein
T5058 12079-12086 NN denotes adaptor
T5057 12070-12078 NN denotes receptor
T5056 12060-12069 NN denotes Toll/IL-1
T5055 12057-12059 IN denotes of
T5054 12045-12056 NN denotes recruitment
T5053 12041-12044 DT denotes the
T5052 12033-12040 VB denotes induces
T5051 12014-12032 NN denotes lipopolysaccharide
T5050 12011-12013 IN denotes by
T5049 11999-12010 NN denotes stimulation
T5048 11994-11998 NN denotes TLR4
T5047 11992-11993 -COMMA- denotes ,
T5046 11985-11992 NN denotes example
T5045 11981-11984 IN denotes For
T5044 11970-11979 NN denotes receptors
T5043 11964-11969 JJ denotes other
T5042 11961-11963 TO denotes to
T5041 11955-11960 VB denotes apply
T5040 11944-11954 NN denotes principles
T5039 11933-11943 NN denotes signalling
T5038 11925-11932 JJ denotes Similar
T5037 11922-11923 -RRB- denotes ]
T5036 11920-11922 CD denotes 23
T5035 11919-11920 -LRB- denotes [
T5034 11911-11918 NN denotes complex
T5033 11906-11910 NN denotes TAK1
T5032 11902-11905 DT denotes the
T5031 11893-11901 VB denotes activate
T5030 11884-11892 RB denotes directly
T5029 11880-11883 MD denotes can
T5028 11873-11879 NN denotes chains
T5027 11859-11872 NN denotes polyubiquitin
T5026 11848-11858 JJ denotes unanchored
T5025 11843-11847 IN denotes that
T5024 11833-11842 VB denotes suggested
T5023 11824-11832 RB denotes recently
T5022 11820-11823 VB denotes was
T5021 11817-11819 PRP denotes it
T5020 11814-11816 IN denotes as
T5019 11812-11813 -COMMA- denotes ,
T5018 11805-11812 JJ denotes unclear
T5017 11797-11804 VB denotes remains
T5016 11790-11796 NN denotes chains
T5015 11776-11789 NN denotes polyubiquitin
T5014 11759-11775 JJ denotes protein-anchored
T5013 11756-11758 IN denotes of
T5012 11751-11755 NN denotes role
T5011 11745-11750 JJ denotes exact
T5010 11741-11744 DT denotes The
T5009 11738-11739 -RRB- denotes ]
T5008 11736-11738 CD denotes 22
T5007 11735-11736 -LRB- denotes [
T5006 11724-11734 NN denotes complexity
T5005 11716-11723 JJ denotes further
T5004 11711-11715 VB denotes adds
T5003 11700-11710 NN denotes signalling
T5002 11694-11699 NN denotes NF-κB
T5001 11680-11693 JJ denotes TNF-activated
T5000 11676-11679 IN denotes for
T4999 11666-11675 JJ denotes essential
T4998 11663-11665 VB denotes is
T4997 11659-11662 CC denotes and
T4996 11652-11658 NN denotes chains
T4995 11638-11651 NN denotes polyubiquitin
T4994 11631-11637 JJ denotes linear
T4993 11626-11630 IN denotes with
T4992 11621-11625 NN denotes NEMO
T4991 11612-11620 VB denotes modifies
T4990 11607-11611 WDT denotes that
T4989 11599-11606 NN denotes complex
T4988 11592-11598 NN denotes enzyme
T4987 11586-11591 NN denotes E2/E3
T4986 11577-11585 JJ denotes distinct
T4985 11575-11576 DT denotes a
T4984 11572-11574 IN denotes of
T4983 11557-11571 NN denotes identification
T4982 11550-11556 JJ denotes recent
T4981 11546-11549 DT denotes The
T4980 11532-11544 RB denotes respectively
T4979 11530-11531 -COMMA- denotes ,
T4978 11524-11530 NN denotes TAB1/2
T4977 11520-11523 CC denotes and
T4976 11515-11519 NN denotes NEMO
T4975 11506-11514 NN denotes proteins
T4974 11488-11505 JJ denotes ubiquitin-binding
T4973 11484-11487 DT denotes the
T4972 11480-11483 IN denotes via
T4971 11472-11479 NN denotes complex
T4970 11467-11471 NN denotes TAK1
T4969 11463-11466 CC denotes and
T4968 11459-11462 NN denotes IKK
T4967 11455-11458 DT denotes the
T4966 11447-11454 VB denotes recruit
T4965 11444-11446 TO denotes to
T4964 11435-11443 NN denotes scaffold
T4963 11433-11434 DT denotes a
T4962 11426-11432 VB denotes create
T4961 11423-11425 TO denotes to
T4960 11414-11422 VB denotes believed
T4959 11410-11413 VB denotes are
T4958 11405-11409 NN denotes RIP1
T4957 11402-11404 IN denotes on
T4956 11395-11401 NN denotes chains
T4955 11381-11394 NN denotes polyubiquitin
T4954 11377-11380 DT denotes The
T5198 12849-12859 NN denotes proteasome
T5197 12845-12848 DT denotes the
T5196 12842-12844 IN denotes by
T5195 12832-12841 VB denotes processed
T5194 12829-12831 VB denotes is
T5193 12824-12828 NN denotes p100
T5192 12822-12823 -COMMA- denotes ,
T5191 12815-12822 NN denotes pathway
T5190 12810-12814 DT denotes this
T5189 12807-12809 IN denotes In
T5188 12804-12805 -RRB- denotes )
T5187 12803-12804 CD denotes 2
T5186 12796-12802 NN denotes Figure
T5185 12795-12796 -LRB- denotes (
T5184 12790-12794 NN denotes RANK
T5183 12786-12789 CC denotes and
T5182 12784-12785 -COMMA- denotes ,
T5181 12780-12784 NN denotes CD40
T5180 12778-12779 -COMMA- denotes ,
T5179 12770-12778 NN denotes receptor
T5178 12765-12769 NN denotes BAFF
T5177 12763-12764 -COMMA- denotes ,
T5176 12755-12763 NN denotes receptor
T5175 12753-12754 NN denotes β
T5174 12741-12752 NN denotes lymphotoxin
T5173 12737-12740 DT denotes the
T5172 12734-12736 IN denotes by
T5171 12724-12733 VB denotes activated
T5170 12721-12723 VB denotes be
T5169 12717-12720 MD denotes can
T5168 12709-12716 NN denotes pathway
T5167 12703-12708 NN denotes NF-κB
T5166 12690-12702 JJ denotes noncanonical
T5165 12686-12689 DT denotes The
T5164 12683-12684 -RRB- denotes )
T5163 12682-12683 CD denotes 1
T5162 12675-12681 NN denotes Figure
T5161 12674-12675 -LRB- denotes (
T5160 12666-12673 NN denotes pathway
T5159 12662-12665 NN denotes TNF
T5158 12658-12661 DT denotes the
T5157 12655-12657 TO denotes to
T5156 12647-12654 JJ denotes similar
T5155 12640-12646 NN denotes manner
T5154 12615-12639 JJ denotes ubiquitination-dependent
T5153 12613-12614 DT denotes a
T5152 12610-12612 IN denotes in
T5151 12606-12609 NN denotes IKK
T5150 12602-12605 CC denotes and
T5149 12597-12601 NN denotes TAK1
T5148 12588-12596 VB denotes activate
T5147 12583-12587 RB denotes then
T5146 12574-12582 NN denotes pathways
T5145 12569-12573 DT denotes Both
T5144 12556-12567 NN denotes interaction
T4737 7939-7954 JJ denotes protein-protein
T4736 7930-7938 JJ denotes proximal
T4735 7927-7929 IN denotes of
T4734 7917-7926 NN denotes formation
T4733 7913-7916 DT denotes the
T4732 7904-7912 VB denotes requires
T4731 7894-7903 NN denotes receptors
T4730 7884-7893 JJ denotes different
T4729 7881-7883 IN denotes by
T4728 7871-7880 VB denotes initiated
T4727 7860-7870 NN denotes signalling
T4726 7854-7859 NN denotes NF-κB
T4725 7845-7852 NN denotes ligands
T4724 7841-7844 NN denotes TLR
T4723 7837-7840 CC denotes and
T4722 7835-7836 -COMMA- denotes ,
T4721 7830-7835 NN denotes RANKL
T4720 7828-7829 -COMMA- denotes ,
T4719 7820-7828 NN denotes antigens
T4718 7818-7819 -COMMA- denotes ,
T4717 7817-7818 -RRB- denotes )
T4716 7813-7817 NN denotes IL-1
T4715 7811-7812 -COMMA- denotes ,
T4714 7808-7811 NN denotes TNF
T4713 7806-7807 -COMMA- denotes ,
T4712 7799-7806 NN denotes example
T4711 7795-7798 IN denotes for
T4710 7794-7795 -LRB- denotes (
T4709 7784-7793 NN denotes cytokines
T4708 7768-7783 JJ denotes proinflammatory
T4707 7758-7767 VB denotes including
T4706 7750-7757 NN denotes stimuli
T4705 7745-7749 JJ denotes many
T4704 7742-7744 IN denotes by
T4703 7732-7741 VB denotes triggered
T4702 7729-7731 VB denotes is
T4701 7725-7728 CC denotes and
T4700 7723-7724 -COMMA- denotes ,
T4699 7715-7723 NN denotes immunity
T4698 7706-7714 JJ denotes adaptive
T4697 7702-7705 CC denotes and
T4696 7695-7701 JJ denotes innate
T4695 7692-7694 IN denotes in
T4694 7687-7691 NN denotes role
T4693 7681-7686 JJ denotes major
T4692 7679-7680 DT denotes a
T4691 7673-7678 VB denotes plays
T4690 7665-7672 NN denotes pathway
T4689 7659-7664 NN denotes NF-κB
T4688 7649-7658 JJ denotes canonical
T4687 7645-7648 DT denotes The
T4686 7635-7643 NN denotes pathways
T4685 7629-7634 NN denotes NF-κB
T4684 7627-7628 -RRB- denotes )
T4683 7616-7627 JJ denotes alternative
T4682 7613-7615 CC denotes or
T4681 7612-7613 -LRB- denotes (
T4680 7599-7611 JJ denotes noncanonical
T4679 7595-7598 CC denotes and
T4678 7593-7594 -RRB- denotes )
T4677 7584-7593 JJ denotes classical
T4676 7581-7583 CC denotes or
T4675 7580-7581 -LRB- denotes (
T4674 7570-7579 JJ denotes canonical
T4673 7563-7569 VB denotes termed
T4672 7561-7562 -COMMA- denotes ,
T4671 7553-7561 NN denotes pathways
T4670 7542-7552 NN denotes signalling
T4669 7536-7541 NN denotes NF-κB
T4668 7529-7535 JJ denotes unique
T4667 7525-7528 CD denotes two
T4666 7521-7524 VB denotes are
T4665 7515-7520 EX denotes There
T4664 7501-7513 RB denotes respectively
T4663 7499-7500 -COMMA- denotes ,
T4662 7491-7499 NN denotes subunits
T4661 7485-7490 NN denotes NF-κB
T4660 7481-7484 NN denotes p50
T4659 7477-7480 CC denotes and
T4658 7473-7476 NN denotes p52
T4657 7469-7472 DT denotes the
T4656 7466-7468 IN denotes of
T2489 6982-6984 NN denotes RA
T2488 6979-6981 IN denotes in
T2487 6968-6978 NN denotes expression
T2486 6963-6967 NN denotes gene
T2485 6950-6962 JJ denotes inflammatory
T2484 6946-6949 CC denotes and
T2483 6935-6945 NN denotes activation
T2482 6929-6934 NN denotes NF-κB
T2481 6926-6928 TO denotes to
T2480 6915-6925 VB denotes contribute
T2479 6911-6914 MD denotes may
T2478 6904-6910 NN denotes tissue
T2477 6898-6903 JJ denotes joint
T2476 6889-6897 JJ denotes inflamed
T2475 6885-6888 DT denotes the
T2474 6882-6884 IN denotes in
T2473 6874-6881 NN denotes ligands
T2472 6870-6873 NN denotes TLR
T2471 6862-6869 JJ denotes several
T2470 6857-6861 IN denotes that
T2469 6849-6856 VB denotes suggest
T2468 6841-6848 NN denotes studies
T2467 6835-6840 DT denotes these
T2466 6833-6834 -COMMA- denotes ,
T2465 6825-6833 RB denotes Together
T2464 6822-6823 -RRB- denotes )
T2463 6821-6822 -RRB- denotes ]
T2462 6816-6821 CD denotes 14,15
T2461 6815-6816 -LRB- denotes [
T2460 6812-6814 IN denotes in
T2459 6803-6811 VB denotes reviewed
T2458 6802-6803 -LRB- denotes (
T2457 6792-6801 NN denotes fragments
T2456 6787-6791 NN denotes acid
T2455 6775-6786 JJ denotes hyal-uronic
T2454 6771-6774 CC denotes and
T2453 6769-6770 -COMMA- denotes ,
T2452 6768-6769 NN denotes C
T2451 6759-6767 NN denotes tenascin
T2450 6757-6758 -COMMA- denotes ,
T2449 6749-6757 NN denotes biglycan
T2448 6747-6748 -COMMA- denotes ,
T2447 6736-6747 NN denotes fibronectin
T2446 6734-6735 -COMMA- denotes ,
T2445 6724-6734 NN denotes fibrinogen
T2444 6721-6723 IN denotes as
T2443 6716-6720 JJ denotes such
T2442 6705-6715 NN denotes components
T2441 6698-6704 NN denotes matrix
T2440 6684-6697 JJ denotes extracellular
T2439 6680-6683 VB denotes are
T2438 6670-6679 NN denotes pathology
T2437 6667-6669 NN denotes RA
T2436 6664-6666 IN denotes in
T2435 6655-6663 VB denotes involved
T2434 6652-6654 VB denotes be
T2433 6648-6651 MD denotes may
T2432 6643-6647 WDT denotes that
T2431 6635-6642 NN denotes ligands
T2430 6631-6634 NN denotes TLR
T2429 6620-6630 JJ denotes endogenous
T2428 6614-6619 JJ denotes Other
T2427 6611-6612 -RRB- denotes ]
T2426 6606-6611 CD denotes 17,18
T2425 6605-6606 -LRB- denotes [
T2424 6602-6604 NN denotes RA
T2423 6599-6601 IN denotes in
T2422 6586-6598 NN denotes inflammation
T2421 6578-6585 JJ denotes chronic
T2420 6565-6577 JJ denotes TLR4-induced
T2419 6562-6564 IN denotes in
T2418 6553-6561 VB denotes involved
T2047 4218-4221 DT denotes the
T2046 4215-4217 IN denotes of
T2045 4207-4214 NN denotes Binding
T2044 4204-4205 -RRB- denotes ]
T2043 4202-4204 CD denotes 10
T2042 4201-4202 -LRB- denotes [
T2041 4197-4200 NN denotes TNF
T2040 4187-4196 VB denotes including
T2039 4177-4186 NN denotes cytokines
T2038 4161-4176 JJ denotes proinflammatory
T2037 4158-4160 IN denotes by
T2036 4146-4157 VB denotes upregulated
T2035 4143-4145 VB denotes be
T2034 4139-4142 MD denotes can
T2033 4135-4138 CC denotes and
T2032 4133-4134 -COMMA- denotes ,
T2031 4128-4133 NN denotes cells
T2030 4118-4127 JJ denotes dendritic
T2029 4114-4117 CC denotes and
T2028 4112-4113 -COMMA- denotes ,
T2027 4101-4112 NN denotes macrophages
T2026 4099-4100 -COMMA- denotes ,
T2025 4094-4099 NN denotes cells
T2024 4092-4093 NN denotes B
T2023 4090-4091 -COMMA- denotes ,
T2022 4085-4090 NN denotes cells
T2021 4076-4084 JJ denotes synovial
T2020 4073-4075 NN denotes RA
T2019 4069-4072 CC denotes and
T2018 4060-4068 NN denotes patients
T2017 4057-4059 NN denotes RA
T2016 4053-4056 CC denotes and
T2015 4046-4052 JJ denotes normal
T2014 4041-4045 IN denotes from
T2013 4029-4040 NN denotes fibroblasts
T2012 4022-4028 NN denotes muscle
T2011 4015-4021 JJ denotes smooth
T2010 4005-4014 VB denotes including
T2009 4003-4004 -COMMA- denotes ,
T2008 3998-4003 NN denotes types
T2007 3993-3997 NN denotes cell
T2006 3990-3992 IN denotes of
T2005 3982-3989 NN denotes variety
T2004 3980-3981 DT denotes a
T2003 3977-3979 IN denotes on
T2002 3967-3976 VB denotes expressed
T2001 3954-3966 RB denotes functionally
T2000 3951-3953 VB denotes is
T1999 3946-3950 WDT denotes that
T1998 3939-3945 NN denotes member
T1997 3932-3938 NN denotes family
T1996 3923-3931 NN denotes receptor
T1995 3919-3922 NN denotes TNF
T1994 3911-3918 DT denotes another
T1993 3908-3910 VB denotes is
T1992 3903-3907 NN denotes CD40
T1991 3900-3901 -RRB- denotes ]
T1990 3899-3900 CD denotes 7
T1989 3898-3899 -LRB- denotes [
T1988 3893-3897 NN denotes loss
T1987 3888-3892 NN denotes bone
T1986 3883-3887 IN denotes with
T1985 3872-3882 VB denotes associated
T1984 3863-3871 NN denotes diseases
T1983 3857-3862 JJ denotes other
T1982 3853-3856 CC denotes and
T1981 3843-3852 NN denotes pathology
T1980 3840-3842 NN denotes RA
T1979 3837-3839 IN denotes in
T1978 3828-3836 VB denotes involved
T1977 3825-3827 VB denotes be
T1976 3822-3824 TO denotes to
T1975 3815-3821 JJ denotes likely
T1974 3811-3814 VB denotes are
T1973 3800-3810 NN denotes signalling
T1972 3789-3799 NN denotes RANK-NF-κB
T1971 3782-3788 JJ denotes proper
T1970 3779-3781 IN denotes in
T1969 3771-3778 NN denotes defects
T1968 3767-3770 CC denotes and
T1967 3765-3766 -COMMA- denotes ,
T1966 3747-3765 NN denotes osteoclastogenesis
T1965 3743-3746 IN denotes for
T1964 3733-3742 JJ denotes important
T1963 3730-3732 VB denotes is
T1962 3728-3729 -COMMA- denotes ,
T1961 3722-3728 NN denotes member
T1960 3715-3721 NN denotes family
T1959 3706-3714 NN denotes receptor
T1958 3702-3705 NN denotes TNF
T1957 3700-3701 DT denotes a
T1956 3698-3699 -COMMA- denotes ,
T1955 3697-3698 -RRB- denotes )
T1954 3693-3697 NN denotes RANK
T1953 3692-3693 -LRB- denotes (
T1952 3686-3691 NN denotes NF-κB
T1951 3683-3685 IN denotes of
T1950 3673-3682 NN denotes activator
T1949 3664-3672 NN denotes receptor
T1948 3661-3663 IN denotes by
T1947 3650-3660 NN denotes activation
T1946 3644-3649 NN denotes NF-κB
T1945 3641-3642 -RRB- denotes )
T1944 3640-3641 -RRB- denotes ]
T1943 3639-3640 CD denotes 3
T1942 3638-3639 -LRB- denotes [
T1941 3635-3637 IN denotes in
T1940 3626-3634 VB denotes reviewed
T1939 3625-3626 -LRB- denotes (
T1938 3622-3624 NN denotes RA
T1937 3619-3621 IN denotes in
T1936 3608-3618 NN denotes activities
T1935 3591-3607 JJ denotes pro-inflammatory
T1934 3585-3590 PRP-DOLLAR- denotes their
T1933 3582-3584 IN denotes of
T1932 3577-3581 JJ denotes most
T1931 3568-3576 VB denotes mediates
T1930 3558-3567 NN denotes cytokines
T1929 3552-3557 DT denotes these
T1928 3549-3551 IN denotes by
T1927 3538-3548 NN denotes activation
T1926 3532-3537 NN denotes NF-κB
T1925 3527-3531 IN denotes that
T1924 3518-3526 VB denotes expected
T1923 3515-3517 VB denotes be
T1922 3511-3514 MD denotes can
T1921 3508-3510 PRP denotes it
T1920 3504-3507 CC denotes and
T1919 3498-3503 NN denotes NF-κB
T1918 3495-3497 IN denotes of
T1917 3484-3494 NN denotes activators
T1916 3477-3483 JJ denotes potent
T1915 3472-3476 RB denotes very
T1914 3467-3471 DT denotes both
T1913 3463-3466 VB denotes are
T1912 3458-3462 NN denotes IL-1
T1911 3454-3457 CC denotes and
T1910 3450-3453 NN denotes TNF
T1909 3447-3448 -RRB- denotes )
T1908 3446-3447 -RRB- denotes ]
T1907 3445-3446 CD denotes 9
T1906 3444-3445 -LRB- denotes [
T1905 3441-3443 IN denotes in
T1904 3432-3440 VB denotes reviewed
T1903 3431-3432 -LRB- denotes (
T1902 3428-3430 NN denotes RA
T1901 3421-3427 JJ denotes severe
T1900 3417-3420 IN denotes for
T1899 3407-3416 NN denotes treatment
T1898 3397-3406 JJ denotes effective
T1897 3394-3396 DT denotes an
T1896 3391-3393 VB denotes is
T1895 3379-3390 NN denotes antagonists
T1894 3375-3378 NN denotes TNF
T1893 3372-3374 IN denotes of
T1892 3357-3371 NN denotes administration
T1891 3353-3356 CC denotes and
T1890 3351-3352 -COMMA- denotes ,
T1889 3347-3351 NN denotes role
T1888 3337-3346 JJ denotes important
T1887 3334-3336 DT denotes an
T1886 3329-3333 VB denotes play
T1885 3324-3328 NN denotes IL-1
T1884 3320-3323 CC denotes and
T1883 3316-3319 NN denotes TNF
T1882 3313-3315 IN denotes as
T1881 3308-3312 JJ denotes such
T1880 3298-3307 NN denotes cytokines
T1879 3282-3297 JJ denotes proinflammatory
T1878 3277-3281 IN denotes that
T1877 3268-3276 VB denotes accepted
T1876 3263-3267 RB denotes well
T1875 3260-3262 VB denotes is
T1874 3257-3259 PRP denotes It
T1873 3253-3255 NN denotes RA
T1872 3250-3252 IN denotes in
T1871 3244-3249 NN denotes NF-κB
T1870 3235-3243 VB denotes activate
T1869 3230-3234 WDT denotes that
T1868 3221-3229 NN denotes triggers
T1867 3211-3220 JJ denotes molecular
T1866 3207-3210 DT denotes the
T1865 3204-3206 IN denotes of
T1864 3189-3203 NN denotes identification
T1863 3185-3188 DT denotes the
T1862 3180-3184 IN denotes with
T1861 3174-3179 NN denotes deals
T1860 3165-3173 NN denotes research
T1859 3160-3164 JJ denotes much
T1858 3158-3159 -COMMA- denotes ,
T1857 3156-3158 NN denotes RA
T1856 3153-3155 IN denotes in
T1855 3140-3152 NN denotes inflammation
T1854 3137-3139 IN denotes of
T1853 3129-3136 NN denotes process
T1852 3125-3128 DT denotes the
T1851 3122-3124 TO denotes to
T1850 3114-3121 JJ denotes central
T1849 3111-3113 VB denotes is
T1848 3105-3110 NN denotes NF-κB
T1847 3099-3104 IN denotes Since
T2417 6550-6552 VB denotes be
T2416 6547-6549 TO denotes to
T2415 6537-6546 VB denotes suggested
T2414 6532-6536 VB denotes been
T2413 6527-6531 VB denotes have
T2412 6523-6526 CC denotes and
T2411 6521-6522 -COMMA- denotes ,
T2410 6516-6521 NN denotes fluid
T2409 6507-6515 JJ denotes synovial
T2408 6504-6506 NN denotes RA
T2407 6501-6503 IN denotes in
T2406 6493-6500 JJ denotes present
T2405 6482-6492 RB denotes abundantly
T2404 6477-6481 RB denotes also
T2403 6473-6476 VB denotes are
T2402 6471-6472 -COMMA- denotes ,
T2401 6463-6471 NN denotes proteins
T2400 6447-6462 JJ denotes calcium-binding
T2399 6444-6446 IN denotes of
T2398 6437-6443 NN denotes family
T2397 6432-6436 NN denotes S100
T2396 6428-6431 DT denotes the
T2395 6425-6427 TO denotes to
T2394 6415-6424 VB denotes belonging
T2393 6405-6414 NN denotes molecules
T2392 6397-6404 NN denotes pattern
T2391 6387-6396 JJ denotes molecular
T2390 6369-6386 JJ denotes damage-associated
T2389 6367-6368 -COMMA- denotes ,
T2388 6365-6367 CD denotes 14
T2387 6357-6364 NN denotes protein
T2386 6341-6356 JJ denotes myeloid-related
T2385 6337-6340 CC denotes and
T2384 6335-6336 CD denotes 8
T2383 6327-6334 NN denotes protein
T2382 6311-6326 JJ denotes Myeloid-related
T2381 6308-6309 -RRB- denotes ]
T2380 6306-6308 CD denotes 16
T2379 6305-6306 -LRB- denotes [
T2378 6300-6304 NN denotes mice
T2377 6297-6299 IN denotes in
T2376 6287-6296 NN denotes arthritis
T2375 6270-6286 JJ denotes collagen-induced
T2374 6262-6269 IN denotes against
T2373 6254-6261 NN denotes protect
T2372 6248-6253 NN denotes HMGB1
T2371 6245-6247 IN denotes of
T2370 6238-6244 NN denotes domain
T2369 6233-6237 NN denotes BoxA
T2368 6220-6232 JJ denotes antagonistic
T2367 6216-6219 DT denotes the
T2366 6213-6215 CC denotes or
T2365 6202-6212 NN denotes antibodies
T2364 6189-6201 VB denotes neutralising
T2363 6183-6188 NN denotes HMGB1
T2362 6179-6182 CC denotes and
T2361 6172-6178 NN denotes tissue
T2360 6163-6171 JJ denotes synovial
T2359 6160-6162 NN denotes RA
T2358 6157-6159 IN denotes in
T2357 6147-6156 VB denotes increased
T2356 6144-6146 VB denotes is
T2355 6138-6143 NN denotes HMGB1
T2354 6127-6136 NN denotes pathology
T2353 6124-6126 NN denotes RA
T2352 6121-6123 IN denotes in
T2351 6112-6120 VB denotes involved
T2350 6104-6111 NN denotes ligands
T2349 6099-6103 NN denotes TLR4
T2348 6088-6098 JJ denotes endogenous
T2347 6079-6087 JJ denotes putative
T2346 6074-6078 RB denotes most
T2345 6070-6073 DT denotes the
T2344 6067-6069 IN denotes of
T2343 6063-6066 CD denotes one
T2342 6060-6062 VB denotes is
T2341 6058-6059 -COMMA- denotes ,
T2340 6053-6058 NN denotes cells
T2339 6044-6052 JJ denotes necrotic
T2338 6041-6043 IN denotes by
T2337 6032-6040 VB denotes released
T2336 6022-6031 RB denotes passively
T2335 6019-6021 CC denotes or
T2334 6007-6018 NN denotes macrophages
T2333 6004-6006 IN denotes by
T2332 5995-6003 VB denotes secreted
T2331 5986-5994 RB denotes actively
T2330 5983-5985 VB denotes be
T2329 5979-5982 MD denotes can
T2328 5974-5978 WDT denotes that
T2327 5964-5973 NN denotes component
T2326 5954-5963 NN denotes chromatin
T2325 5944-5953 VB denotes conserved
T2324 5937-5943 RB denotes highly
T2323 5935-5936 DT denotes a
T2322 5933-5934 -COMMA- denotes ,
T2321 5932-5933 -RRB- denotes )
T2320 5927-5932 NN denotes HMGB1
T2319 5926-5927 -LRB- denotes (
T2318 5924-5925 CD denotes 1
T2317 5916-5923 NN denotes protein
T2316 5904-5915 JJ denotes chromosomal
T2315 5900-5903 NN denotes box
T2314 5894-5899 NN denotes group
T2313 5885-5893 NN denotes mobility
T2312 5880-5884 JJ denotes High
T2311 5871-5878 NN denotes disease
T2310 5867-5870 DT denotes the
T2309 5864-5866 IN denotes of
T2308 5851-5863 NN denotes pathogenesis
T2307 5847-5850 DT denotes the
T2306 5844-5846 IN denotes in
T2305 5834-5843 JJ denotes important
T2304 5828-5833 VB denotes being
T2303 5825-5827 IN denotes as
T2302 5812-5824 NN denotes inflammation
T2301 5798-5811 JJ denotes TLR-dependent
T2300 5789-5797 VB denotes identify
T2299 5781-5788 RB denotes clearly
T2298 5770-5780 NN denotes signalling
T2297 5766-5769 NN denotes TLR
T2296 5760-5765 VB denotes block
T2295 5757-5759 TO denotes to
T2294 5746-5756 NN denotes strategies
T2293 5743-5745 CC denotes or
T2292 5738-5742 NN denotes mice
T2291 5729-5737 NN denotes knockout
T2290 5725-5728 NN denotes TLR
T2289 5719-5724 VB denotes using
T2288 5712-5718 NN denotes models
T2287 5705-5711 NN denotes animal
T2286 5703-5704 -COMMA- denotes ,
T2285 5695-5703 RB denotes Moreover
T2284 5685-5693 NN denotes patients
T2283 5682-5684 NN denotes RA
T2282 5679-5681 IN denotes of
T2281 5672-5678 NN denotes joints
T2280 5663-5671 JJ denotes inflamed
T2279 5659-5662 DT denotes the
T2278 5652-5658 IN denotes within
T2277 5644-5651 JJ denotes present
T2276 5640-5643 VB denotes are
T2275 5632-5639 NN denotes ligands
T2274 5621-5631 JJ denotes endogenous
T2273 5613-5620 JJ denotes various
T2272 5609-5612 CC denotes and
T2237 5403-5405 IN denotes of
T2236 5397-5402 NN denotes group
T2235 5395-5396 DT denotes a
T2234 5393-5394 -COLON- denotes -
T2233 5385-5392 NN denotes ligands
T2232 5374-5384 JJ denotes endogenous
T2231 5371-5373 IN denotes of
T2230 5364-5370 NN denotes number
T2229 5353-5363 VB denotes increasing
T2228 5350-5352 DT denotes an
T2227 5348-5349 -COMMA- denotes ,
T2226 5341-5348 NN denotes ligands
T2225 5331-5340 JJ denotes microbial
T2224 5328-5330 TO denotes to
T2223 5319-5327 NN denotes addition
T2222 5316-5318 IN denotes In
T2221 5312-5314 NN denotes RA
T2220 5309-5311 IN denotes in
T2219 5296-5308 NN denotes inflammation
T2218 5280-5295 JJ denotes NF-κB-dependent
T2217 5271-5279 VB denotes inducing
T2216 5267-5270 IN denotes for
T2215 5256-5266 NN denotes candidates
T2214 5246-5255 JJ denotes potential
T2213 5242-5245 VB denotes are
T2212 5238-5241 CC denotes and
T2211 5229-5237 NN denotes diseases
T2210 5218-5228 JJ denotes autoimmune
T2209 5215-5217 IN denotes of
T2208 5207-5214 NN denotes variety
T2207 5205-5206 DT denotes a
T2206 5202-5204 IN denotes in
T2205 5191-5201 VB denotes implicated
T2204 5186-5190 VB denotes been
T2203 5181-5185 VB denotes have
T2202 5179-5180 -RRB- denotes )
T2201 5175-5179 NN denotes TLRs
T2200 5174-5175 -LRB- denotes (
T2199 5164-5173 NN denotes receptors
T2198 5154-5163 JJ denotes Toll-like
T2197 5151-5152 -RRB- denotes ]
T2196 5149-5151 CD denotes 13
T2195 5148-5149 -LRB- denotes [
T2194 5145-5147 NN denotes RA
T2193 5135-5144 VB denotes including
T2192 5122-5134 NN denotes inflammation
T2191 5114-5121 JJ denotes chronic
T2190 5111-5113 IN denotes of
T2189 5105-5110 NN denotes sites
T2188 5102-5104 IN denotes at
T2187 5092-5101 NN denotes formation
T2186 5086-5091 NN denotes organ
T2185 5077-5085 JJ denotes lymphoid
T2184 5068-5076 JJ denotes tertiary
T2183 5065-5067 IN denotes in
T2182 5054-5064 VB denotes implicated
T2181 5049-5053 VB denotes been
T2180 5045-5048 VB denotes has
T2179 5034-5044 NN denotes signalling
T2178 5025-5033 NN denotes receptor
T2177 5023-5024 NN denotes β
T2176 5011-5022 NN denotes lymphotoxin
T2175 5009-5010 -COMMA- denotes ,
T2174 5002-5009 RB denotes Finally
T2173 4999-5000 -RRB- denotes ]
T2172 4997-4999 CD denotes 13
T2171 4996-4997 -LRB- denotes [
T2170 4993-4995 NN denotes RA
T2169 4985-4992 VB denotes counter
T2168 4982-4984 TO denotes to
T2167 4972-4981 VB denotes developed
T2166 4967-4971 VB denotes been
T2165 4962-4966 VB denotes have
T2164 4957-4961 NN denotes BAFF
T2163 4954-4956 IN denotes of
T2162 4942-4953 NN denotes antagonists
T2161 4938-4941 CC denotes and
T2160 4936-4937 -COMMA- denotes ,
T2159 4934-4936 NN denotes RA
T2158 4930-4933 IN denotes for
T2157 4915-4929 JJ denotes characteristic
T2156 4910-4914 RB denotes also
T2155 4907-4909 VB denotes is
T2154 4905-4906 -COMMA- denotes ,
T2153 4894-4905 NN denotes lymphocytes
T2152 4892-4893 NN denotes B
T2151 4882-4891 VB denotes producing
T2150 4868-4881 NN denotes autoantibody-
T2149 4865-4867 IN denotes of
T2148 4856-4864 NN denotes survival
T2147 4852-4855 DT denotes the
T2146 4843-4851 VB denotes allowing
T2145 4841-4842 -COMMA- denotes ,
T2144 4840-4841 -RRB- denotes )
T2143 4836-4840 NN denotes BAFF
T2142 4835-4836 -LRB- denotes (
T2141 4828-4834 NN denotes factor
T2140 4817-4827 VB denotes activating
T2139 4810-4816 NN denotes B-cell
T2138 4803-4809 NN denotes member
T2137 4796-4802 NN denotes family
T2136 4787-4795 NN denotes receptor
T2135 4783-4786 NN denotes TNF
T2134 4779-4782 DT denotes the
T2133 4776-4778 IN denotes of
T2132 4765-4775 NN denotes expression
T2131 4756-4764 VB denotes Enhanced
T2130 4753-4754 -RRB- denotes ]
T2129 4748-4753 CD denotes 11,12
T2128 4747-4748 -LRB- denotes [
T2127 4739-4746 JJ denotes present
T2126 4731-4738 RB denotes already
T2125 4727-4730 VB denotes are
T2124 4716-4726 NN denotes antibodies
T2123 4705-4715 JJ denotes pathogenic
T2122 4701-4704 CC denotes and
T2121 4689-4700 VB denotes established
T2120 4686-4688 VB denotes is
T2119 4678-4685 NN denotes disease
T2118 4673-4677 RB denotes once
T2117 4664-4672 VB denotes required
T2116 4660-4663 RB denotes not
T2115 4656-4659 VB denotes are
T2114 4652-4655 CC denotes but
T2113 4650-4651 -COMMA- denotes ,
T2112 4641-4650 NN denotes induction
T2111 4631-4640 NN denotes arthritis
T2110 4628-4630 IN denotes of
T2109 4621-4627 NN denotes stages
T2108 4613-4620 JJ denotes initial
T2107 4609-4612 DT denotes the
T2106 4606-4608 IN denotes at
T2105 4596-4605 JJ denotes important
T2104 4593-4595 VB denotes be
T2103 4589-4592 MD denotes may
T2102 4581-4588 NN denotes signals
T2101 4576-4580 NN denotes CD40
T2100 4571-4575 IN denotes that
T2099 4560-4570 NN denotes conclusion
T2098 4556-4559 DT denotes the
T2097 4553-4555 TO denotes to
T2096 4549-4552 VB denotes led
T2095 4538-4548 NN denotes antibodies
T2094 4527-4537 JJ denotes anti-CD154
T2093 4524-4526 CC denotes or
T2092 4514-4523 NN denotes anti-CD40
T2091 4501-4513 JJ denotes antagonistic
T2090 4496-4500 IN denotes with
T2089 4488-4495 NN denotes studies
T2088 4486-4487 -COMMA- denotes ,
T2087 4479-4486 RB denotes However
T2086 4466-4477 NN denotes destruction
T2085 4460-4465 JJ denotes joint
T2084 4457-4459 TO denotes to
T2083 4445-4456 VB denotes contributes
T2082 4439-4444 WDT denotes which
T2081 4437-4438 -COMMA- denotes ,
T2080 4427-4437 NN denotes chemokines
T2079 4423-4426 CC denotes and
T2078 4413-4422 NN denotes cytokines
T2077 4397-4412 JJ denotes proinflammatory
T2076 4394-4396 IN denotes of
T2075 4384-4393 NN denotes secretion
T2074 4380-4383 CC denotes and
T2073 4366-4379 NN denotes proliferation
T2072 4355-4365 NN denotes fibroblast
T2071 4352-4354 IN denotes in
T2070 4342-4351 VB denotes resulting
T2069 4331-4341 NN denotes activation
T2068 4325-4330 NN denotes NF-κB
T2067 4316-4324 VB denotes triggers
T2066 4314-4315 -COMMA- denotes ,
T2065 4309-4314 NN denotes cells
T2064 4307-4308 NN denotes T
T2063 4302-4306 JJ denotes CD4+
T2062 4292-4301 VB denotes activated
T2061 4289-4291 IN denotes of
T2060 4281-4288 NN denotes surface
T2059 4277-4280 DT denotes the
T2058 4274-4276 IN denotes on
T2057 4264-4273 VB denotes expressed
T2056 4252-4263 RB denotes transiently
T2055 4249-4251 VB denotes is
T2054 4243-4248 WDT denotes which
T2053 4241-4242 -COMMA- denotes ,
T2052 4240-4241 -RRB- denotes )
T2051 4235-4240 NN denotes CD154
T2050 4234-4235 -LRB- denotes (
T2049 4227-4233 NN denotes ligand
T2048 4222-4226 NN denotes CD40
T2271 5601-5608 NN denotes tissues
T2270 5592-5600 JJ denotes synovial
T2269 5589-5591 NN denotes RA
T2268 5586-5588 IN denotes in
T2267 5576-5585 VB denotes expressed
T2266 5572-5575 VB denotes are
T2265 5567-5571 NN denotes TLRs
T2264 5564-5565 -RRB- denotes )
T2263 5563-5564 -RRB- denotes ]
T2262 5558-5563 CD denotes 14,15
T2261 5557-5558 -LRB- denotes [
T2260 5554-5556 IN denotes in
T2259 5545-5553 VB denotes reviewed
T2258 5544-5545 -LRB- denotes (
T2257 5531-5543 NN denotes inflammation
T2256 5523-5530 JJ denotes sterile
T2255 5513-5522 JJ denotes so-called
T2254 5504-5512 VB denotes inducing
T2253 5499-5503 NN denotes TLRs
T2252 5496-5498 IN denotes of
T2251 5485-5495 NN denotes activators
T2250 5475-5484 NN denotes candidate
T2249 5472-5474 IN denotes as
T2248 5463-5471 VB denotes reported
T2247 5458-5462 VB denotes been
T2246 5453-5457 VB denotes have
T2245 5451-5452 -COLON- denotes -
T2244 5445-5450 NN denotes cells
T2243 5441-5444 CC denotes and
T2242 5433-5440 NN denotes tissues
T2241 5428-5432 NN denotes host
T2240 5423-5427 IN denotes from
T2239 5415-5422 VB denotes derived
T2238 5406-5414 NN denotes proteins
T718 2709-2712 DT denotes the
T776 3047-3048 -RRB- denotes ]
T774 3045-3046 -LRB- denotes [
T773 3032-3044 NN denotes pathogenesis
T772 3029-3031 NN denotes RA
T771 3026-3028 IN denotes in
T770 3015-3025 NN denotes activation
T769 3009-3014 NN denotes NF-κB
T768 3006-3008 IN denotes of
T767 2995-3005 NN denotes importance
T766 2991-2994 DT denotes the
T765 2981-2990 VB denotes highlight
T764 2973-2980 RB denotes further
T763 2971-2972 -COMMA- denotes ,
T762 2966-2971 NN denotes c-REL
T761 2962-2965 CC denotes and
T760 2960-2961 -COMMA- denotes ,
T759 2953-2960 NN denotes TNFAIP3
T758 2951-2952 -COMMA- denotes ,
T757 2946-2951 NN denotes TRAF1
T756 2944-2945 -COMMA- denotes ,
T755 2940-2944 NN denotes CD40
T754 2930-2939 VB denotes including
T753 2928-2929 -COMMA- denotes ,
T752 2918-2928 NN denotes signalling
T751 2912-2917 NN denotes NF-κB
T750 2909-2911 TO denotes to
T749 2900-2908 JJ denotes relevant
T748 2894-2899 NN denotes genes
T747 2886-2893 JJ denotes several
T746 2881-2885 IN denotes with
T745 2869-2880 NN denotes association
T744 2861-2868 JJ denotes genetic
T743 2859-2860 DT denotes a
T742 2849-2858 VB denotes revealing
T741 2837-2848 NN denotes discoveries
T740 2830-2836 JJ denotes recent
T739 2828-2829 -COMMA- denotes ,
T738 2821-2828 RB denotes Finally
T737 2818-2819 -RRB- denotes ]
T736 2817-2818 CD denotes 7
T735 2816-2817 -LRB- denotes [
T734 2813-2815 NN denotes RA
T733 2810-2812 IN denotes as
T732 2805-2809 JJ denotes such
T731 2796-2804 NN denotes diseases
T730 2785-2795 JJ denotes osteolytic
T729 2782-2784 IN denotes in
T728 2774-2781 NN denotes erosion
T727 2769-2773 NN denotes bone
T726 2766-2768 IN denotes of
T725 2760-2765 NN denotes cause
T724 2754-2759 JJ denotes major
T723 2750-2753 DT denotes the
T722 2746-2749 VB denotes are
T721 2727-2745 NN denotes osteoclastogenesis
T720 2724-2726 IN denotes of
T719 2713-2723 NN denotes regulation
T717 2706-2708 IN denotes in
T716 2698-2705 NN denotes Defects
T715 2695-2696 -RRB- denotes )
T714 2690-2695 NN denotes RANKL
T713 2689-2690 -LRB- denotes (
T712 2682-2688 NN denotes ligand
T711 2676-2681 NN denotes NF-κB
T710 2673-2675 IN denotes of
T709 2663-2672 NN denotes activator
T708 2654-2662 NN denotes receptor
T707 2651-2653 IN denotes of
T706 2643-2650 NN denotes effects
T705 2639-2642 DT denotes the
T704 2629-2638 VB denotes mediating
T703 2626-2628 IN denotes by
T702 2619-2625 RB denotes mainly
T701 2617-2618 -COMMA- denotes ,
T700 2599-2617 NN denotes osteoclastogenesis
T699 2595-2598 IN denotes for
T698 2585-2594 JJ denotes essential
T697 2580-2584 RB denotes also
T696 2577-2579 VB denotes is
T695 2571-2576 NN denotes NF-κB
T694 2569-2570 -COMMA- denotes ,
T693 2559-2569 NN denotes expression
T668 2421-2424 DT denotes the
T667 2413-2420 VB denotes precede
T666 2410-2412 TO denotes to
T665 2402-2409 VB denotes appears
T664 2391-2401 NN denotes activation
T663 2385-2390 NN denotes NF-κB
T662 2382-2384 IN denotes of
T661 2375-2381 NN denotes course
T660 2370-2374 NN denotes time
T659 2366-2369 DT denotes The
T658 2363-2364 -RRB- denotes )
T657 2362-2363 -RRB- denotes ]
T656 2361-2362 CD denotes 4
T655 2360-2361 -LRB- denotes [
T654 2357-2359 IN denotes in
T653 2348-2356 VB denotes reviewed
T652 2347-2348 -LRB- denotes (
T651 2344-2346 NN denotes RA
T650 2341-2343 IN denotes of
T649 2329-2340 NN denotes progression
T648 2325-2328 CC denotes and
T647 2313-2324 NN denotes development
T646 2309-2312 DT denotes the
T645 2306-2308 IN denotes in
T644 2300-2305 NN denotes NF-κB
T643 2297-2299 IN denotes of
T642 2292-2296 NN denotes role
T641 2285-2291 JJ denotes active
T640 2281-2284 DT denotes the
T639 2269-2280 VB denotes demonstrate
T638 2264-2268 RB denotes also
T637 2254-2263 NN denotes arthritis
T636 2241-2253 JJ denotes inflammatory
T635 2238-2240 IN denotes of
T634 2231-2237 NN denotes models
T633 2224-2230 NN denotes animal
T632 2220-2223 CC denotes and
T631 2218-2219 -COMMA- denotes ,
T630 2210-2218 NN denotes patients
T629 2207-2209 NN denotes RA
T628 2202-2206 IN denotes from
T627 2195-2201 NN denotes tissue
T626 2186-2194 JJ denotes synovial
T625 2182-2185 CC denotes and
T624 2170-2181 NN denotes fibroblasts
T623 2161-2169 JJ denotes synovial
T622 2152-2160 VB denotes cultured
T621 2149-2151 IN denotes in
T620 2140-2148 VB denotes detected
T619 2137-2139 VB denotes be
T618 2133-2136 MD denotes can
T617 2122-2132 NN denotes activation
T616 2116-2121 NN denotes NF-κB
T615 2113-2114 -RRB- denotes )
T614 2112-2113 -RRB- denotes ]
T613 2109-2112 CD denotes 2,3
T612 2108-2109 -LRB- denotes [
T611 2105-2107 IN denotes in
T610 2096-2104 VB denotes reviewed
T609 2095-2096 -LRB- denotes (
T608 2089-2094 NN denotes NF-κB
T607 2086-2088 IN denotes of
T606 2075-2085 NN denotes activators
T605 2068-2074 JJ denotes potent
T604 2063-2067 RB denotes very
T603 2052-2062 PRP denotes themselves
T602 2048-2051 VB denotes are
T601 2043-2047 NN denotes IL-1
T600 2039-2042 CC denotes and
T599 2035-2038 NN denotes TNF
T598 2033-2034 -COMMA- denotes ,
T597 2025-2033 NN denotes addition
T596 2022-2024 IN denotes In
T595 2018-2020 NN denotes RA
T594 2015-2017 IN denotes in
T593 2006-2014 VB denotes involved
T592 2002-2005 VB denotes are
T591 1997-2001 WDT denotes that
T590 1995-1996 -COLON- denotes -
T589 1976-1994 NN denotes metalloproteinases
T588 1969-1975 NN denotes matrix
T587 1965-1968 CC denotes and
T586 1963-1964 -COMMA- denotes ,
T585 1955-1963 NN denotes synthase
T584 1949-1954 NN denotes oxide
T583 1942-1948 JJ denotes nitric
T582 1932-1941 JJ denotes inducible
T581 1930-1931 -COMMA- denotes ,
T580 1920-1930 NN denotes chemokines
T579 1918-1919 -COMMA- denotes ,
T578 1901-1918 NN denotes cyclo-oxygenase-2
T577 1899-1900 -COMMA- denotes ,
T576 1895-1899 NN denotes IL-6
T575 1893-1894 -COMMA- denotes ,
T574 1889-1893 NN denotes IL-1
T573 1887-1888 -COMMA- denotes ,
T572 1884-1887 NN denotes TNF
T571 1881-1883 IN denotes as
T570 1876-1880 JJ denotes such
T569 1874-1875 -COLON- denotes -
T568 1868-1873 NN denotes genes
T567 1865-1867 IN denotes of
T566 1858-1864 NN denotes number
T565 1852-1857 JJ denotes large
T564 1850-1851 DT denotes a
T563 1847-1849 IN denotes of
T562 1836-1846 NN denotes expression
T561 1832-1835 DT denotes the
T560 1823-1831 VB denotes regulate
T559 1818-1822 WDT denotes that
T558 1814-1817 CC denotes and
T557 1812-1813 -COMMA- denotes ,
T556 1811-1812 -RRB- denotes ]
T555 1810-1811 CD denotes 1
T554 1809-1810 -LRB- denotes [
T553 1796-1808 NN denotes heterodimers
T552 1793-1795 CC denotes or
T551 1782-1792 NN denotes homodimers
T550 1779-1781 IN denotes as
T549 1770-1778 VB denotes function
T548 1765-1769 WDT denotes that
T547 1763-1764 -RRB- denotes )
T546 1758-1763 NN denotes c-Rel
T545 1756-1757 -COMMA- denotes ,
T544 1752-1756 NN denotes RelB
T543 1750-1751 -COMMA- denotes ,
T542 1746-1750 NN denotes RelA
T541 1743-1745 CC denotes or
T540 1739-1742 NN denotes p65
T539 1737-1738 -COMMA- denotes ,
T538 1731-1737 NN denotes NF-κB1
T537 1728-1730 CC denotes or
T536 1723-1727 NN denotes p105
T535 1721-1722 -COMMA- denotes ,
T534 1715-1721 NN denotes NF-κB2
T533 1712-1714 CC denotes or
T532 1707-1711 NN denotes p100
T531 1706-1707 -LRB- denotes (
T530 1697-1705 NN denotes proteins
T529 1687-1696 VB denotes conserved
T528 1672-1686 RB denotes evolutionarily
T527 1668-1671 CC denotes and
T526 1660-1667 VB denotes related
T525 1647-1659 RB denotes structurally
T524 1644-1646 IN denotes of
T523 1637-1643 NN denotes family
T522 1635-1636 DT denotes a
T521 1624-1634 VB denotes represents
T520 1618-1623 NN denotes NF-κB
T519 1608-1616 NN denotes diseases
T518 1597-1607 JJ denotes autoimmune
T517 1591-1596 JJ denotes other
T516 1586-1590 JJ denotes many
T515 1582-1585 CC denotes and
T514 1579-1581 NN denotes RA
T513 1576-1578 IN denotes of
T512 1564-1575 NN denotes development
T511 1560-1563 DT denotes the
T510 1557-1559 IN denotes in
T509 1552-1556 NN denotes role
T508 1548-1551 JJ denotes key
T507 1546-1547 DT denotes a
T506 1540-1545 VB denotes plays
T505 1529-1539 NN denotes expression
T504 1524-1528 NN denotes gene
T503 1508-1523 JJ denotes NF-κB-dependent
T502 1505-1507 IN denotes of
T501 1494-1504 NN denotes activation
T500 1489-1493 IN denotes that
T499 1480-1488 VB denotes accepted
T498 1475-1479 RB denotes well
T497 1472-1474 VB denotes is
T496 1469-1471 PRP denotes it
T495 1465-1468 CC denotes but
T494 1463-1464 -COMMA- denotes ,
T493 1453-1463 VB denotes understood
T492 1449-1452 RB denotes not
T491 1443-1448 RB denotes still
T490 1440-1442 VB denotes is
T489 1437-1439 NN denotes RA
T488 1434-1436 IN denotes of
T487 1424-1433 NN denotes aetiology
T486 1420-1423 DT denotes The
T485 1414-1418 NN denotes bone
T484 1402-1413 JJ denotes subchondral
T483 1398-1401 CC denotes and
T482 1388-1397 NN denotes cartilage
T481 1378-1387 JJ denotes articular
T480 1369-1377 VB denotes degrades
T479 1365-1368 CC denotes and
T478 1357-1364 VB denotes invades
T477 1351-1356 WDT denotes which
T476 1349-1350 -COMMA- denotes ,
T475 1343-1349 NN denotes tissue
T474 1336-1342 NN denotes pannus
T473 1333-1335 IN denotes of
T472 1323-1332 NN denotes formation
T471 1319-1322 DT denotes the
T470 1316-1318 TO denotes to
T469 1310-1315 VB denotes leads
T468 1298-1309 NN denotes fibroblasts
T467 1289-1297 JJ denotes synovial
T466 1286-1288 IN denotes of
T465 1272-1285 NN denotes Proliferation
T464 1265-1270 NN denotes cells
T463 1256-1264 JJ denotes synovial
T462 1252-1255 CC denotes and
T461 1242-1251 NN denotes monocytes
T460 1229-1241 VB denotes infiltrating
T459 1226-1228 IN denotes by
T458 1207-1225 NN denotes metalloproteinases
T457 1200-1206 NN denotes matrix
T456 1196-1199 CC denotes and
T455 1194-1195 -COMMA- denotes ,
T454 1184-1194 NN denotes chemokines
T453 1182-1183 -COMMA- denotes ,
T440 1096-1099 DT denotes the
T439 1089-1095 VB denotes drives
T438 1083-1088 NN denotes space
T437 1077-1082 JJ denotes joint
T436 1073-1076 DT denotes the
T435 1068-1072 IN denotes into
T434 1061-1067 NN denotes system
T433 1054-1060 JJ denotes immune
T432 1045-1053 JJ denotes adaptive
T431 1041-1044 CC denotes and
T430 1034-1040 JJ denotes innate
T429 1030-1033 DT denotes the
T428 1027-1029 IN denotes of
T427 1021-1026 NN denotes cells
T426 1018-1020 IN denotes of
T425 1005-1017 NN denotes Infiltration
T424 993-1003 NN denotes disability
T423 989-992 CC denotes and
T422 981-988 NN denotes decline
T421 970-980 JJ denotes functional
T692 2554-2558 NN denotes gene
T691 2538-2553 JJ denotes proinflammatory
T690 2535-2537 IN denotes in
T689 2530-2534 NN denotes role
T688 2526-2529 PRP-DOLLAR- denotes its
T687 2523-2525 TO denotes to
T686 2518-2522 JJ denotes Next
T685 2515-2516 -RRB- denotes ]
T684 2512-2515 CD denotes 5,6
T683 2511-2512 -LRB- denotes [
T682 2502-2510 NN denotes severity
T681 2494-2501 NN denotes disease
T680 2484-2493 VB denotes decreases
T679 2478-2483 NN denotes means
T678 2468-2477 JJ denotes different
T677 2465-2467 IN denotes by
T676 2459-2464 NN denotes NF-κB
T675 2456-2458 IN denotes of
T674 2447-2455 NN denotes blockade
T673 2443-2446 CC denotes and
T672 2441-2442 -COMMA- denotes ,
T671 2434-2441 NN denotes disease
T670 2431-2433 IN denotes of
T669 2425-2430 NN denotes onset
T44 284-285 -COMMA- denotes ,
T43 276-284 NN denotes diseases
T42 263-275 JJ denotes inflammatory
T41 259-262 CC denotes and
T40 248-258 JJ denotes autoimmune
T39 243-247 JJ denotes many
T38 238-242 IN denotes with
T37 231-237 VB denotes linked
T36 226-230 VB denotes been
T35 222-225 VB denotes has
T34 213-221 NN denotes activity
T33 207-212 NN denotes NF-κB
T32 193-206 JJ denotes inappropriate
T31 189-192 CC denotes and
T30 187-188 -COMMA- denotes ,
T29 178-187 NN denotes responses
T28 172-177 JJ denotes mmune
T27 168-171 CC denotes and
T26 155-167 NN denotes inflammation
T25 152-154 IN denotes of
T24 141-151 NN denotes regulation
T23 137-140 DT denotes the
T22 134-136 IN denotes in
T21 128-133 NN denotes roles
T20 120-127 JJ denotes crucial
T19 114-119 VB denotes plays
T18 108-113 NN denotes NF-κB
T17 101-107 NN denotes factor
T16 87-100 NN denotes transcription
T15 83-86 DT denotes The
T452 1173-1182 NN denotes cytokines
T451 1170-1172 CD denotes 17
T450 1165-1169 NN denotes type
T449 1156-1164 NN denotes T-helper
T448 1152-1155 CC denotes and
T447 1150-1151 CD denotes 1
T446 1145-1149 NN denotes type
T445 1136-1144 NN denotes T-helper
T444 1120-1135 JJ denotes proinflammatory
T443 1117-1119 IN denotes of
T442 1106-1116 NN denotes production
T441 1100-1105 JJ denotes local
T98 662-671 NN denotes arthritis
T97 651-661 JJ denotes rheumatoid
T96 648-650 IN denotes of
T95 635-647 NN denotes pathogenesis
T94 631-634 DT denotes the
T93 628-630 IN denotes in
T92 617-627 VB denotes implicated
T91 612-616 VB denotes been
T90 607-611 VB denotes have
T89 601-606 WDT denotes which
T88 597-600 CC denotes and
T87 586-596 NN denotes signalling
T86 580-585 NN denotes NF-κB
T85 572-579 VB denotes control
T84 569-571 TO denotes to
T83 561-568 VB denotes evolved
T82 556-560 VB denotes have
T81 551-555 WDT denotes that
T80 540-550 NN denotes mechanisms
T79 529-539 JJ denotes regulatory
T78 520-528 JJ denotes negative
T77 512-519 JJ denotes various
T76 505-511 VB denotes review
T75 500-504 MD denotes will
T74 497-499 PRP denotes we
T73 492-496 RB denotes Here
T72 481-490 NN denotes responses
T71 475-480 NN denotes NF-κB
T70 472-474 IN denotes of
T69 460-471 NN denotes termination
T68 451-459 VB denotes ensuring
T67 440-450 NN denotes regulators
T66 431-439 NN denotes feedback
T65 422-430 JJ denotes negative
T64 419-421 IN denotes of
T63 408-418 NN denotes repertoire
T62 406-407 DT denotes a
T61 396-405 VB denotes including
T60 394-395 -COMMA- denotes ,
T59 389-394 NN denotes check
T58 386-388 IN denotes in
T57 375-385 NN denotes signalling
T56 369-374 NN denotes NF-κB
T55 364-368 VB denotes keep
T54 361-363 TO denotes to
T53 354-360 NN denotes system
T52 346-353 NN denotes control
T51 333-345 JJ denotes multilayered
T50 331-332 DT denotes a
T49 324-330 VB denotes employ
T48 318-323 NN denotes Cells
T47 307-316 NN denotes arthritis
T46 296-306 JJ denotes rheumatoid
T45 286-295 VB denotes including
T390 773-774 NN denotes %
T389 772-773 CD denotes 1
T388 769-771 TO denotes to
T387 766-768 IN denotes up
T386 756-765 VB denotes affecting
T385 754-755 -COMMA- denotes ,
T384 745-754 NN denotes arthritis
T383 732-744 JJ denotes inflammatory
T420 967-969 TO denotes to
T419 959-966 VB denotes leading
T418 957-958 -COMMA- denotes ,
T417 953-957 NN denotes bone
T416 949-952 CC denotes and
T415 939-948 NN denotes cartilage
T414 936-938 IN denotes of
T413 924-935 NN denotes destruction
T412 912-923 JJ denotes progressive
T411 910-911 DT denotes a
T410 905-909 IN denotes with
T409 894-904 VB denotes associated
T408 891-893 VB denotes is
T407 884-890 NN denotes joints
T406 881-883 IN denotes of
T405 868-880 NN denotes inflammation
T404 860-867 JJ denotes chronic
T403 854-859 WDT denotes which
T402 851-853 IN denotes in
T401 837-850 NN denotes polyarthritis
T400 825-836 JJ denotes symmetrical
T399 823-824 DT denotes a
T398 820-822 IN denotes by
T397 806-819 VB denotes characterised
T396 803-805 VB denotes is
T395 800-802 NN denotes RA
T394 788-798 NN denotes population
T393 782-787 JJ denotes adult
T392 778-781 DT denotes the
T391 775-777 IN denotes of
T382 725-731 JJ denotes common
T381 720-724 RB denotes most
T380 716-719 DT denotes the
T379 713-715 VB denotes is
T378 711-712 -RRB- denotes )
T377 709-711 NN denotes RA
T376 708-709 -LRB- denotes (
T375 698-707 NN denotes arthritis
T374 687-697 JJ denotes Rheumatoid
T15548 27358-27362 NN denotes IL-1
T19037 33648-33650 NN denotes RA
T19036 33645-33647 IN denotes as
T19035 33640-33644 JJ denotes such
T19034 33631-33639 NN denotes diseases
R1933 T2438 T2437 arg1Of pathology,RA
R1934 T2442 T2440 arg1Of components,extracellular
R1935 T2442 T2441 arg1Of components,matrix
R3886 T5372 T5374 arg1Of and,mediate
R3887 T5431 T5429 arg2Of activation,in
R3888 T5431 T5430 arg1Of activation,the
R3889 T5431 T5432 arg1Of activation,of
R3890 T5435 T5432 arg2Of pathway,of
R5839 T8669 T8668 arg1Of degradation,IκBα
R5840 T8671 T8670 arg2Of 34,[
R5841 T8672 T8670 arg3Of ],[
R7225 T10620 T10619 arg1Of tools,valuable
R9626 T14515 T14516 arg1Of it,is
R9627 T14515 T14517 arg1Of it,worth
R9628 T14516 T14511 arg1Of is,In
R11003 T16656 T16657 arg1Of work,in
R11004 T16656 T16662 arg1Of work,demonstrates
R11005 T16660 T16657 arg2Of population,in
R11006 T16660 T16658 arg1Of population,a
R13240 T19944 T19943 arg1Of kinase,IL-1R-associated
R13241 T19946 T19947 arg1Of MyD88,","
R14175 T21693 T21691 arg1Of regulator,a
R14176 T21693 T21692 arg1Of regulator,negative
R14177 T21693 T21694 arg1Of regulator,of
R1 T6 T5 arg1Of regulation,Negative
R2 T6 T7 arg1Of regulation,of
R3 T6 T9 arg1Of regulation,and
R4 T8 T7 arg2Of NF-κB,of
R5 T11 T9 arg2Of involvement,and
R6 T11 T10 arg1Of involvement,its
R7 T11 T12 arg1Of involvement,in
R8 T14 T12 arg2Of arthritis,in
R9 T14 T13 arg1Of arthritis,rheumatoid
R10 T18 T15 arg1Of NF-κB,The
R11 T18 T16 arg1Of NF-κB,transcription
R12 T18 T17 arg1Of NF-κB,factor
R13 T18 T19 arg1Of NF-κB,plays
R14 T19 T22 arg1Of plays,in
R15 T19 T31 arg1Of plays,and
R16 T21 T19 arg2Of roles,plays
R17 T21 T20 arg1Of roles,crucial
R18 T24 T22 arg2Of regulation,in
R19 T24 T23 arg1Of regulation,the
R20 T24 T25 arg1Of regulation,of
R21 T26 T27 arg1Of inflammation,and
R22 T27 T25 arg2Of and,of
R23 T29 T27 arg2Of responses,and
R24 T29 T28 arg1Of responses,mmune
R25 T31 T30 arg1Of and,","
R26 T34 T32 arg1Of activity,inappropriate
R27 T34 T33 arg1Of activity,NF-κB
R28 T34 T35 arg1Of activity,has
R29 T34 T36 arg1Of activity,been
R30 T34 T37 arg2Of activity,linked
R31 T37 T31 arg2Of linked,and
R32 T37 T35 arg2Of linked,has
R33 T37 T36 arg2Of linked,been
R34 T37 T38 arg1Of linked,with
R35 T40 T41 arg1Of autoimmune,and
R36 T42 T41 arg2Of inflammatory,and
R37 T43 T38 arg2Of diseases,with
R38 T43 T39 arg1Of diseases,many
R39 T43 T40 arg1Of diseases,autoimmune
R40 T43 T42 arg1Of diseases,inflammatory
R41 T43 T44 arg1Of diseases,","
R42 T43 T45 arg1Of diseases,including
R43 T47 T45 arg2Of arthritis,including
R44 T47 T46 arg1Of arthritis,rheumatoid
R45 T48 T49 arg1Of Cells,employ
R46 T49 T54 modOf employ,to
R47 T53 T49 arg2Of system,employ
R48 T53 T50 arg1Of system,a
R49 T53 T51 arg1Of system,multilayered
R50 T53 T52 arg1Of system,control
R51 T55 T54 arg1Of keep,to
R52 T55 T58 arg1Of keep,in
R53 T57 T55 arg2Of signalling,keep
R54 T57 T56 arg1Of signalling,NF-κB
R55 T59 T58 arg2Of check,in
R56 T59 T60 arg1Of check,","
R57 T59 T61 arg1Of check,including
R58 T63 T61 arg2Of repertoire,including
R59 T63 T62 arg1Of repertoire,a
R60 T63 T64 arg1Of repertoire,of
R61 T67 T64 arg2Of regulators,of
R62 T67 T65 arg1Of regulators,negative
R63 T67 T66 arg1Of regulators,feedback
R64 T67 T68 arg1Of regulators,ensuring
R65 T69 T68 arg2Of termination,ensuring
R66 T69 T70 arg1Of termination,of
R67 T72 T70 arg2Of responses,of
R68 T72 T71 arg1Of responses,NF-κB
R69 T74 T75 arg1Of we,will
R70 T74 T76 arg1Of we,review
R71 T76 T73 arg1Of review,Here
R72 T76 T75 arg2Of review,will
R73 T80 T76 arg2Of mechanisms,review
R74 T80 T77 arg1Of mechanisms,various
R75 T80 T78 arg1Of mechanisms,negative
R76 T80 T79 arg1Of mechanisms,regulatory
R77 T80 T81 arg1Of mechanisms,that
R78 T80 T82 arg1Of mechanisms,have
R79 T80 T83 arg1Of mechanisms,evolved
R80 T80 T85 arg1Of mechanisms,control
R81 T80 T89 arg1Of mechanisms,which
R82 T80 T90 arg1Of mechanisms,have
R83 T80 T91 arg1Of mechanisms,been
R84 T80 T92 arg2Of mechanisms,implicated
R85 T83 T82 arg2Of evolved,have
R86 T83 T88 arg1Of evolved,and
R87 T85 T83 arg2Of control,evolved
R88 T85 T84 arg1Of control,to
R89 T87 T85 arg2Of signalling,control
R90 T87 T86 arg1Of signalling,NF-κB
R91 T92 T88 arg2Of implicated,and
R92 T92 T90 arg2Of implicated,have
R93 T92 T91 arg2Of implicated,been
R94 T92 T93 arg1Of implicated,in
R95 T95 T93 arg2Of pathogenesis,in
R96 T95 T94 arg1Of pathogenesis,the
R97 T95 T96 arg1Of pathogenesis,of
R98 T98 T96 arg2Of arthritis,of
R99 T98 T97 arg1Of arthritis,rheumatoid
R243 T384 T380 arg1Of arthritis,the
R244 T384 T382 arg1Of arthritis,common
R245 T384 T383 arg1Of arthritis,inflammatory
R246 T389 T387 arg1Of 1,up
R247 T389 T388 arg1Of 1,to
R248 T390 T386 arg2Of %,affecting
R249 T390 T389 arg1Of %,1
R250 T390 T391 arg1Of %,of
R251 T394 T391 arg2Of population,of
R252 T394 T392 arg1Of population,the
R253 T394 T393 arg1Of population,adult
R254 T395 T396 arg1Of RA,is
R255 T395 T397 arg2Of RA,characterised
R256 T397 T396 arg2Of characterised,is
R257 T401 T397 arg1Of polyarthritis,characterised
R258 T401 T398 arg2Of polyarthritis,by
R259 T401 T399 arg1Of polyarthritis,a
R260 T401 T400 arg1Of polyarthritis,symmetrical
R261 T401 T402 arg2Of polyarthritis,in
R262 T401 T403 arg1Of polyarthritis,which
R263 T405 T404 arg1Of inflammation,chronic
R264 T405 T406 arg1Of inflammation,of
R265 T405 T408 arg1Of inflammation,is
R266 T405 T409 arg2Of inflammation,associated
R267 T407 T406 arg2Of joints,of
R268 T409 T402 arg1Of associated,in
R269 T409 T408 arg2Of associated,is
R270 T409 T410 arg1Of associated,with
R271 T409 T418 arg1Of associated,","
R272 T409 T419 modOf associated,leading
R273 T413 T410 arg2Of destruction,with
R274 T413 T411 arg1Of destruction,a
R275 T413 T412 arg1Of destruction,progressive
R276 T413 T414 arg1Of destruction,of
R277 T415 T416 arg1Of cartilage,and
R278 T416 T414 arg2Of and,of
R279 T417 T416 arg2Of bone,and
R280 T419 T420 arg1Of leading,to
R281 T422 T423 arg1Of decline,and
R282 T423 T420 arg2Of and,to
R283 T423 T421 arg1Of and,functional
R284 T424 T423 arg2Of disability,and
R285 T425 T426 arg1Of Infiltration,of
R286 T425 T435 arg1Of Infiltration,into
R287 T425 T439 arg1Of Infiltration,drives
R288 T425 T460 arg1Of Infiltration,infiltrating
R289 T427 T426 arg2Of cells,of
R290 T427 T428 arg1Of cells,of
R291 T430 T431 arg1Of innate,and
R292 T432 T431 arg2Of adaptive,and
R293 T434 T428 arg2Of system,of
R294 T434 T429 arg1Of system,the
R295 T434 T430 arg1Of system,innate
R296 T434 T432 arg1Of system,adaptive
R297 T434 T433 arg1Of system,immune
R298 T438 T435 arg2Of space,into
R299 T438 T436 arg1Of space,the
R300 T438 T437 arg1Of space,joint
R301 T439 T459 arg1Of drives,by
R302 T442 T439 arg2Of production,drives
R303 T442 T440 arg1Of production,the
R304 T442 T441 arg1Of production,local
R305 T442 T443 arg1Of production,of
R306 T447 T448 arg1Of 1,and
R307 T449 T448 arg2Of T-helper,and
R308 T452 T444 arg1Of cytokines,proinflammatory
R309 T452 T445 arg1Of cytokines,T-helper
R310 T452 T446 arg1Of cytokines,type
R311 T452 T447 arg1Of cytokines,1
R312 T452 T449 arg1Of cytokines,T-helper
R313 T452 T450 arg1Of cytokines,type
R314 T452 T451 arg1Of cytokines,17
R315 T452 T453 arg1Of cytokines,","
R316 T453 T456 arg1Of ",",and
R317 T454 T453 arg2Of chemokines,","
R318 T456 T443 arg2Of and,of
R319 T456 T455 arg1Of and,","
R320 T458 T456 arg2Of metalloproteinases,and
R321 T458 T457 arg1Of metalloproteinases,matrix
R322 T460 T459 arg2Of infiltrating,by
R323 T461 T462 arg1Of monocytes,and
R324 T462 T460 arg2Of and,infiltrating
R325 T464 T462 arg2Of cells,and
R326 T464 T463 arg1Of cells,synovial
R327 T465 T466 arg1Of Proliferation,of
R328 T465 T469 arg1Of Proliferation,leads
R329 T468 T466 arg2Of fibroblasts,of
R330 T468 T467 arg1Of fibroblasts,synovial
R331 T469 T470 arg1Of leads,to
R332 T472 T470 arg2Of formation,to
R333 T472 T471 arg1Of formation,the
R334 T472 T473 arg1Of formation,of
R335 T475 T473 arg2Of tissue,of
R336 T475 T474 arg1Of tissue,pannus
R337 T475 T476 arg1Of tissue,","
R338 T475 T477 arg1Of tissue,which
R339 T475 T478 arg1Of tissue,invades
R340 T475 T480 arg1Of tissue,degrades
R341 T478 T479 arg1Of invades,and
R342 T480 T479 arg2Of degrades,and
R343 T482 T481 arg1Of cartilage,articular
R344 T482 T483 arg1Of cartilage,and
R345 T483 T478 arg2Of and,invades
R346 T483 T480 arg2Of and,degrades
R347 T485 T483 arg2Of bone,and
R348 T485 T484 arg1Of bone,subchondral
R349 T487 T486 arg1Of aetiology,The
R350 T487 T488 arg1Of aetiology,of
R351 T487 T490 arg1Of aetiology,is
R352 T487 T493 arg2Of aetiology,understood
R353 T489 T488 arg2Of RA,of
R354 T493 T490 arg2Of understood,is
R355 T493 T491 arg1Of understood,still
R356 T493 T492 arg1Of understood,not
R357 T493 T495 arg1Of understood,but
R358 T495 T494 arg1Of but,","
R359 T496 T497 arg1Of it,is
R360 T496 T499 arg2Of it,accepted
R361 T499 T495 arg2Of accepted,but
R362 T499 T497 arg2Of accepted,is
R363 T499 T498 arg1Of accepted,well
R364 T501 T502 arg1Of activation,of
R365 T501 T506 arg1Of activation,plays
R366 T505 T502 arg2Of expression,of
R367 T505 T503 arg1Of expression,NF-κB-dependent
R368 T505 T504 arg1Of expression,gene
R369 T506 T499 arg3Of plays,accepted
R370 T506 T500 arg1Of plays,that
R371 T506 T510 arg1Of plays,in
R372 T509 T506 arg2Of role,plays
R373 T509 T507 arg1Of role,a
R374 T509 T508 arg1Of role,key
R375 T512 T510 arg2Of development,in
R376 T512 T511 arg1Of development,the
R377 T512 T513 arg1Of development,of
R378 T514 T515 arg1Of RA,and
R379 T515 T513 arg2Of and,of
R380 T519 T515 arg2Of diseases,and
R381 T519 T516 arg1Of diseases,many
R382 T519 T517 arg1Of diseases,other
R383 T519 T518 arg1Of diseases,autoimmune
R384 T520 T521 arg1Of NF-κB,represents
R385 T523 T521 arg2Of family,represents
R386 T523 T522 arg1Of family,a
R387 T523 T524 arg1Of family,of
R388 T523 T569 arg1Of family,-
R389 T523 T571 arg1Of family,as
R390 T526 T525 arg1Of related,structurally
R391 T526 T527 arg1Of related,and
R392 T529 T527 arg2Of conserved,and
R393 T529 T528 arg1Of conserved,evolutionarily
R394 T530 T524 arg2Of proteins,of
R395 T530 T526 arg1Of proteins,related
R396 T530 T529 arg1Of proteins,conserved
R397 T530 T531 arg1Of proteins,(
R398 T530 T548 arg1Of proteins,that
R399 T530 T549 arg1Of proteins,function
R400 T530 T559 arg1Of proteins,that
R401 T530 T560 arg1Of proteins,regulate
R402 T532 T533 arg1Of p100,or
R403 T533 T535 arg1Of or,","
R404 T534 T533 arg2Of NF-κB2,or
R405 T535 T539 arg1Of ",",","
R406 T536 T537 arg1Of p105,or
R407 T537 T535 arg2Of or,","
R408 T538 T537 arg2Of NF-κB1,or
R409 T539 T541 arg1Of ",",or
R410 T540 T539 arg2Of p65,","
R411 T541 T531 arg2Of or,(
R412 T542 T541 arg2Of RelA,or
R413 T542 T543 arg1Of RelA,","
R414 T542 T545 arg1Of RelA,","
R415 T544 T543 arg2Of RelB,","
R416 T546 T545 arg2Of c-Rel,","
R417 T547 T531 arg3Of ),(
R418 T549 T550 arg1Of function,as
R419 T549 T558 arg1Of function,and
R420 T551 T552 arg1Of homodimers,or
R421 T552 T550 arg2Of or,as
R422 T552 T554 arg1Of or,[
R423 T553 T552 arg2Of heterodimers,or
R424 T555 T554 arg2Of 1,[
R425 T556 T554 arg3Of ],[
R426 T558 T557 arg1Of and,","
R427 T560 T558 arg2Of regulate,and
R428 T562 T560 arg2Of expression,regulate
R429 T562 T561 arg1Of expression,the
R430 T562 T563 arg1Of expression,of
R431 T566 T563 arg2Of number,of
R432 T566 T564 arg1Of number,a
R433 T566 T565 arg1Of number,large
R434 T566 T567 arg1Of number,of
R435 T568 T567 arg2Of genes,of
R436 T571 T570 arg1Of as,such
R437 T572 T573 arg1Of TNF,","
R438 T573 T575 arg1Of ",",","
R439 T574 T573 arg2Of IL-1,","
R440 T575 T577 arg1Of ",",","
R441 T576 T575 arg2Of IL-6,","
R442 T577 T579 arg1Of ",",","
R443 T578 T577 arg2Of cyclo-oxygenase-2,","
R444 T579 T581 arg1Of ",",","
R445 T580 T579 arg2Of chemokines,","
R446 T581 T587 arg1Of ",",and
R447 T585 T581 arg2Of synthase,","
R448 T585 T582 arg1Of synthase,inducible
R449 T585 T583 arg1Of synthase,nitric
R450 T585 T584 arg1Of synthase,oxide
R451 T587 T571 arg2Of and,as
R452 T587 T586 arg1Of and,","
R453 T589 T587 arg2Of metalloproteinases,and
R454 T589 T588 arg1Of metalloproteinases,matrix
R455 T589 T590 arg1Of metalloproteinases,-
R456 T589 T591 arg1Of metalloproteinases,that
R457 T589 T592 arg1Of metalloproteinases,are
R458 T589 T593 arg2Of metalloproteinases,involved
R459 T593 T592 arg2Of involved,are
R460 T593 T594 arg1Of involved,in
R461 T595 T594 arg2Of RA,in
R462 T597 T596 arg2Of addition,In
R463 T599 T600 arg1Of TNF,and
R464 T600 T602 arg1Of and,are
R465 T601 T600 arg2Of IL-1,and
R466 T602 T596 arg1Of are,In
R467 T602 T598 arg1Of are,","
R468 T603 T602 arg2Of themselves,are
R469 T603 T606 arg1Of themselves,activators
R470 T605 T604 arg1Of potent,very
R471 T606 T605 arg1Of activators,potent
R472 T606 T607 arg1Of activators,of
R473 T606 T609 arg1Of activators,(
R474 T608 T607 arg2Of NF-κB,of
R475 T610 T609 arg2Of reviewed,(
R476 T610 T611 arg1Of reviewed,in
R477 T610 T612 arg1Of reviewed,[
R478 T613 T612 arg2Of "2,3",[
R479 T614 T612 arg3Of ],[
R480 T615 T609 arg3Of ),(
R481 T617 T616 arg1Of activation,NF-κB
R482 T617 T618 arg1Of activation,can
R483 T617 T619 arg1Of activation,be
R484 T617 T620 arg2Of activation,detected
R485 T620 T618 arg2Of detected,can
R486 T620 T619 arg2Of detected,be
R487 T620 T621 arg1Of detected,in
R488 T620 T632 arg1Of detected,and
R489 T624 T622 arg2Of fibroblasts,cultured
R490 T624 T623 arg1Of fibroblasts,synovial
R491 T624 T625 arg1Of fibroblasts,and
R492 T625 T621 arg2Of and,in
R493 T627 T625 arg2Of tissue,and
R494 T627 T626 arg1Of tissue,synovial
R495 T627 T628 arg1Of tissue,from
R496 T630 T628 arg2Of patients,from
R497 T630 T629 arg1Of patients,RA
R498 T632 T631 arg1Of and,","
R499 T634 T633 arg1Of models,animal
R500 T634 T635 arg1Of models,of
R501 T634 T639 arg1Of models,demonstrate
R502 T637 T635 arg2Of arthritis,of
R503 T637 T636 arg1Of arthritis,inflammatory
R504 T639 T632 arg2Of demonstrate,and
R505 T639 T638 arg1Of demonstrate,also
R506 T642 T639 arg2Of role,demonstrate
R507 T642 T640 arg1Of role,the
R508 T642 T641 arg1Of role,active
R509 T642 T643 arg1Of role,of
R510 T642 T645 arg1Of role,in
R511 T642 T652 arg1Of role,(
R512 T644 T643 arg2Of NF-κB,of
R513 T647 T648 arg1Of development,and
R514 T648 T645 arg2Of and,in
R515 T648 T646 arg1Of and,the
R516 T648 T650 arg1Of and,of
R517 T649 T648 arg2Of progression,and
R518 T651 T650 arg2Of RA,of
R519 T653 T652 arg2Of reviewed,(
R520 T653 T654 arg1Of reviewed,in
R521 T653 T655 arg1Of reviewed,[
R522 T656 T655 arg2Of 4,[
R523 T657 T655 arg3Of ],[
R524 T658 T652 arg3Of ),(
R525 T661 T659 arg1Of course,The
R526 T661 T660 arg1Of course,time
R527 T661 T662 arg1Of course,of
R528 T661 T665 arg1Of course,appears
R529 T661 T667 arg1Of course,precede
R530 T664 T662 arg2Of activation,of
R531 T664 T663 arg1Of activation,NF-κB
R532 T665 T673 arg1Of appears,and
R533 T667 T665 arg2Of precede,appears
R534 T667 T666 arg1Of precede,to
R535 T669 T667 arg2Of onset,precede
R536 T669 T668 arg1Of onset,the
R537 T669 T670 arg1Of onset,of
R538 T671 T670 arg2Of disease,of
R539 T673 T672 arg1Of and,","
R540 T674 T675 arg1Of blockade,of
R541 T674 T677 arg1Of blockade,by
R542 T674 T680 arg1Of blockade,decreases
R543 T676 T675 arg2Of NF-κB,of
R544 T679 T677 arg2Of means,by
R545 T679 T678 arg1Of means,different
R546 T680 T673 arg2Of decreases,and
R547 T680 T683 arg1Of decreases,[
R548 T682 T680 arg2Of severity,decreases
R549 T682 T681 arg1Of severity,disease
R550 T684 T683 arg2Of "5,6",[
R551 T685 T683 arg3Of ],[
R552 T686 T687 arg1Of Next,to
R553 T689 T687 arg2Of role,to
R554 T689 T688 arg1Of role,its
R555 T689 T690 arg1Of role,in
R556 T693 T690 arg2Of expression,in
R557 T693 T691 arg1Of expression,proinflammatory
R558 T693 T692 arg1Of expression,gene
R559 T695 T696 arg1Of NF-κB,is
R560 T695 T698 arg1Of NF-κB,essential
R561 T695 T704 arg1Of NF-κB,mediating
R562 T696 T686 arg1Of is,Next
R563 T696 T694 arg1Of is,","
R564 T696 T697 arg1Of is,also
R565 T696 T701 arg1Of is,","
R566 T696 T703 arg1Of is,by
R567 T698 T696 arg2Of essential,is
R568 T698 T699 arg1Of essential,for
R569 T700 T699 arg2Of osteoclastogenesis,for
R570 T703 T702 arg1Of by,mainly
R571 T704 T703 arg2Of mediating,by
R572 T706 T704 arg2Of effects,mediating
R573 T706 T705 arg1Of effects,the
R574 T706 T707 arg1Of effects,of
R575 T709 T707 arg2Of activator,of
R576 T709 T708 arg1Of activator,receptor
R577 T709 T710 arg1Of activator,of
R578 T712 T710 arg2Of ligand,of
R579 T712 T711 arg1Of ligand,NF-κB
R580 T712 T713 arg1Of ligand,(
R581 T714 T713 arg2Of RANKL,(
R582 T715 T713 arg3Of ),(
R583 T716 T717 arg1Of Defects,in
R584 T716 T722 arg1Of Defects,are
R585 T719 T717 arg2Of regulation,in
R586 T719 T718 arg1Of regulation,the
R587 T719 T720 arg1Of regulation,of
R588 T721 T720 arg2Of osteoclastogenesis,of
R589 T722 T729 arg1Of are,in
R590 T725 T722 arg2Of cause,are
R591 T725 T723 arg1Of cause,the
R592 T725 T724 arg1Of cause,major
R593 T725 T726 arg1Of cause,of
R594 T728 T726 arg2Of erosion,of
R595 T728 T727 arg1Of erosion,bone
R596 T731 T729 arg2Of diseases,in
R597 T731 T730 arg1Of diseases,osteolytic
R598 T731 T733 arg1Of diseases,as
R599 T733 T732 arg1Of as,such
R600 T734 T733 arg2Of RA,as
R601 T734 T735 arg1Of RA,[
R602 T736 T735 arg2Of 7,[
R603 T737 T735 arg3Of ],[
R604 T741 T740 arg1Of discoveries,recent
R605 T741 T742 arg1Of discoveries,revealing
R606 T741 T765 arg1Of discoveries,highlight
R607 T745 T742 arg2Of association,revealing
R608 T745 T743 arg1Of association,a
R609 T745 T744 arg1Of association,genetic
R610 T745 T746 arg1Of association,with
R611 T748 T746 arg2Of genes,with
R612 T748 T747 arg1Of genes,several
R613 T748 T749 arg1Of genes,relevant
R614 T748 T753 arg1Of genes,","
R615 T748 T754 arg1Of genes,including
R616 T749 T750 arg1Of relevant,to
R617 T752 T750 arg2Of signalling,to
R618 T752 T751 arg1Of signalling,NF-κB
R619 T755 T756 arg1Of CD40,","
R620 T756 T758 arg1Of ",",","
R621 T757 T756 arg2Of TRAF1,","
R622 T758 T761 arg1Of ",",and
R623 T759 T758 arg2Of TNFAIP3,","
R624 T761 T754 arg2Of and,including
R625 T761 T760 arg1Of and,","
R626 T762 T761 arg2Of c-REL,and
R627 T765 T738 arg1Of highlight,Finally
R628 T765 T739 arg1Of highlight,","
R629 T765 T763 arg1Of highlight,","
R630 T765 T764 arg1Of highlight,further
R631 T765 T774 arg1Of highlight,[
R632 T767 T765 arg2Of importance,highlight
R633 T767 T766 arg1Of importance,the
R634 T767 T768 arg1Of importance,of
R635 T767 T771 arg1Of importance,in
R636 T770 T768 arg2Of activation,of
R637 T770 T769 arg1Of activation,NF-κB
R638 T773 T771 arg2Of pathogenesis,in
R639 T773 T772 arg1Of pathogenesis,RA
R640 T775 T774 arg2Of 8,[
R641 T776 T774 arg3Of ],[
R1314 T1848 T1849 arg1Of NF-κB,is
R1315 T1848 T1850 arg1Of NF-κB,central
R1316 T1849 T1847 arg2Of is,Since
R1317 T1849 T1862 arg1Of is,with
R1318 T1850 T1849 arg2Of central,is
R1319 T1850 T1851 arg1Of central,to
R1320 T1853 T1851 arg2Of process,to
R1321 T1853 T1852 arg1Of process,the
R1322 T1853 T1854 arg1Of process,of
R1323 T1853 T1856 arg1Of process,in
R1324 T1853 T1858 arg1Of process,","
R1325 T1855 T1854 arg2Of inflammation,of
R1326 T1857 T1856 arg2Of RA,in
R1327 T1861 T1858 arg2Of deals,","
R1328 T1861 T1859 arg1Of deals,much
R1329 T1861 T1860 arg1Of deals,research
R1330 T1864 T1862 arg2Of identification,with
R1331 T1864 T1863 arg1Of identification,the
R1332 T1864 T1865 arg1Of identification,of
R1333 T1868 T1865 arg2Of triggers,of
R1334 T1868 T1866 arg1Of triggers,the
R1335 T1868 T1867 arg1Of triggers,molecular
R1336 T1869 T1870 arg1Of that,activate
R1337 T1870 T1847 arg1Of activate,Since
R1338 T1870 T1872 arg1Of activate,in
R1339 T1871 T1870 arg2Of NF-κB,activate
R1340 T1873 T1872 arg2Of RA,in
R1341 T1874 T1875 arg1Of It,is
R1342 T1874 T1877 arg2Of It,accepted
R1343 T1877 T1875 arg2Of accepted,is
R1344 T1877 T1876 arg1Of accepted,well
R1345 T1880 T1879 arg1Of cytokines,proinflammatory
R1346 T1880 T1882 arg1Of cytokines,as
R1347 T1880 T1886 arg1Of cytokines,play
R1348 T1882 T1881 arg1Of as,such
R1349 T1883 T1884 arg1Of TNF,and
R1350 T1884 T1882 arg2Of and,as
R1351 T1885 T1884 arg2Of IL-1,and
R1352 T1886 T1891 arg1Of play,and
R1353 T1889 T1886 arg2Of role,play
R1354 T1889 T1887 arg1Of role,an
R1355 T1889 T1888 arg1Of role,important
R1356 T1891 T1877 arg3Of and,accepted
R1357 T1891 T1878 arg1Of and,that
R1358 T1891 T1890 arg1Of and,","
R1359 T1892 T1893 arg1Of administration,of
R1360 T1892 T1896 arg1Of administration,is
R1361 T1895 T1893 arg2Of antagonists,of
R1362 T1895 T1894 arg1Of antagonists,TNF
R1363 T1896 T1891 arg2Of is,and
R1364 T1899 T1896 arg2Of treatment,is
R1365 T1899 T1897 arg1Of treatment,an
R1366 T1899 T1898 arg1Of treatment,effective
R1367 T1899 T1900 arg1Of treatment,for
R1368 T1902 T1900 arg2Of RA,for
R1369 T1902 T1901 arg1Of RA,severe
R1370 T1902 T1903 arg1Of RA,(
R1371 T1904 T1903 arg2Of reviewed,(
R1372 T1904 T1905 arg1Of reviewed,in
R1373 T1904 T1906 arg1Of reviewed,[
R1374 T1907 T1906 arg2Of 9,[
R1375 T1908 T1906 arg3Of ],[
R1376 T1909 T1903 arg3Of ),(
R1377 T1910 T1911 arg1Of TNF,and
R1378 T1911 T1913 arg1Of and,are
R1379 T1912 T1911 arg2Of IL-1,and
R1380 T1913 T1920 arg1Of are,and
R1381 T1916 T1915 arg1Of potent,very
R1382 T1917 T1913 arg2Of activators,are
R1383 T1917 T1914 arg1Of activators,both
R1384 T1917 T1916 arg1Of activators,potent
R1385 T1917 T1918 arg1Of activators,of
R1386 T1919 T1918 arg2Of NF-κB,of
R1387 T1921 T1922 arg1Of it,can
R1388 T1921 T1923 arg1Of it,be
R1389 T1921 T1924 arg2Of it,expected
R1390 T1924 T1920 arg2Of expected,and
R1391 T1924 T1922 arg2Of expected,can
R1392 T1924 T1923 arg2Of expected,be
R1393 T1927 T1926 arg1Of activation,NF-κB
R1394 T1927 T1928 arg1Of activation,by
R1395 T1927 T1931 arg1Of activation,mediates
R1396 T1930 T1928 arg2Of cytokines,by
R1397 T1930 T1929 arg1Of cytokines,these
R1398 T1931 T1924 arg3Of mediates,expected
R1399 T1931 T1925 arg1Of mediates,that
R1400 T1932 T1931 arg2Of most,mediates
R1401 T1932 T1933 arg1Of most,of
R1402 T1936 T1933 arg2Of activities,of
R1403 T1936 T1934 arg1Of activities,their
R1404 T1936 T1935 arg1Of activities,pro-inflammatory
R1405 T1936 T1937 arg1Of activities,in
R1406 T1938 T1937 arg2Of RA,in
R1407 T1938 T1939 arg1Of RA,(
R1408 T1940 T1939 arg2Of reviewed,(
R1409 T1940 T1941 arg1Of reviewed,in
R1410 T1940 T1942 arg1Of reviewed,[
R1411 T1943 T1942 arg2Of 3,[
R1412 T1944 T1942 arg3Of ],[
R1413 T1945 T1939 arg3Of ),(
R1414 T1947 T1946 arg1Of activation,NF-κB
R1415 T1947 T1948 arg1Of activation,by
R1416 T1947 T1963 arg1Of activation,is
R1417 T1947 T1964 arg1Of activation,important
R1418 T1950 T1948 arg2Of activator,by
R1419 T1950 T1949 arg1Of activator,receptor
R1420 T1950 T1951 arg1Of activator,of
R1421 T1952 T1951 arg2Of NF-κB,of
R1422 T1952 T1953 arg1Of NF-κB,(
R1423 T1952 T1956 arg1Of NF-κB,","
R1424 T1954 T1953 arg2Of RANK,(
R1425 T1955 T1953 arg3Of ),(
R1426 T1961 T1956 arg2Of member,","
R1427 T1961 T1957 arg1Of member,a
R1428 T1961 T1958 arg1Of member,TNF
R1429 T1961 T1959 arg1Of member,receptor
R1430 T1961 T1960 arg1Of member,family
R1431 T1963 T1962 arg1Of is,","
R1432 T1963 T1968 arg1Of is,and
R1433 T1964 T1963 arg2Of important,is
R1434 T1964 T1965 arg1Of important,for
R1435 T1966 T1965 arg2Of osteoclastogenesis,for
R1436 T1968 T1967 arg1Of and,","
R1437 T1969 T1970 arg1Of defects,in
R1438 T1969 T1974 arg1Of defects,are
R1439 T1969 T1975 arg1Of defects,likely
R1440 T1969 T1977 arg1Of defects,be
R1441 T1969 T1978 arg2Of defects,involved
R1442 T1973 T1970 arg2Of signalling,in
R1443 T1973 T1971 arg1Of signalling,proper
R1444 T1973 T1972 arg1Of signalling,RANK-NF-κB
R1445 T1974 T1968 arg2Of are,and
R1446 T1975 T1974 arg2Of likely,are
R1447 T1978 T1975 arg2Of involved,likely
R1448 T1978 T1976 arg1Of involved,to
R1449 T1978 T1977 arg2Of involved,be
R1450 T1978 T1979 arg1Of involved,in
R1451 T1981 T1980 arg1Of pathology,RA
R1452 T1981 T1982 arg1Of pathology,and
R1453 T1982 T1979 arg2Of and,in
R1454 T1982 T1985 arg2Of and,associated
R1455 T1984 T1982 arg2Of diseases,and
R1456 T1984 T1983 arg1Of diseases,other
R1457 T1985 T1986 arg1Of associated,with
R1458 T1988 T1986 arg2Of loss,with
R1459 T1988 T1987 arg1Of loss,bone
R1460 T1988 T1989 arg1Of loss,[
R1461 T1990 T1989 arg2Of 7,[
R1462 T1991 T1989 arg3Of ],[
R1463 T1992 T1993 arg1Of CD40,is
R1464 T1998 T1993 arg2Of member,is
R1465 T1998 T1994 arg1Of member,another
R1466 T1998 T1995 arg1Of member,TNF
R1467 T1998 T1996 arg1Of member,receptor
R1468 T1998 T1997 arg1Of member,family
R1469 T1998 T1999 arg1Of member,that
R1470 T1998 T2000 arg1Of member,is
R1471 T1998 T2002 arg2Of member,expressed
R1472 T1998 T2034 arg1Of member,can
R1473 T1998 T2035 arg1Of member,be
R1474 T1998 T2036 arg2Of member,upregulated
R1475 T2002 T2000 arg2Of expressed,is
R1476 T2002 T2001 arg1Of expressed,functionally
R1477 T2002 T2003 arg1Of expressed,on
R1478 T2002 T2033 arg1Of expressed,and
R1479 T2005 T2003 arg2Of variety,on
R1480 T2005 T2004 arg1Of variety,a
R1481 T2005 T2006 arg1Of variety,of
R1482 T2008 T2007 arg1Of types,cell
R1483 T2008 T2009 arg1Of types,","
R1484 T2008 T2010 arg1Of types,including
R1485 T2008 T2023 arg1Of types,","
R1486 T2013 T2010 arg2Of fibroblasts,including
R1487 T2013 T2011 arg1Of fibroblasts,smooth
R1488 T2013 T2012 arg1Of fibroblasts,muscle
R1489 T2013 T2014 arg1Of fibroblasts,from
R1490 T2015 T2016 arg1Of normal,and
R1491 T2017 T2016 arg2Of RA,and
R1492 T2018 T2015 arg1Of patients,normal
R1493 T2018 T2017 arg1Of patients,RA
R1494 T2018 T2019 arg1Of patients,and
R1495 T2019 T2014 arg2Of and,from
R1496 T2022 T2019 arg2Of cells,and
R1497 T2022 T2020 arg1Of cells,RA
R1498 T2022 T2021 arg1Of cells,synovial
R1499 T2023 T2006 arg2Of ",",of
R1500 T2025 T2024 arg1Of cells,B
R1501 T2025 T2026 arg1Of cells,","
R1502 T2026 T2029 arg1Of ",",and
R1503 T2027 T2026 arg2Of macrophages,","
R1504 T2029 T2023 arg2Of and,","
R1505 T2029 T2028 arg1Of and,","
R1506 T2031 T2029 arg2Of cells,and
R1507 T2031 T2030 arg1Of cells,dendritic
R1508 T2033 T2032 arg1Of and,","
R1509 T2036 T2033 arg2Of upregulated,and
R1510 T2036 T2034 arg2Of upregulated,can
R1511 T2036 T2035 arg2Of upregulated,be
R1512 T2039 T2036 arg1Of cytokines,upregulated
R1513 T2039 T2037 arg2Of cytokines,by
R1514 T2039 T2038 arg1Of cytokines,proinflammatory
R1515 T2039 T2040 arg1Of cytokines,including
R1516 T2041 T2040 arg2Of TNF,including
R1517 T2041 T2042 arg1Of TNF,[
R1518 T2043 T2042 arg2Of 10,[
R1519 T2044 T2042 arg3Of ],[
R1520 T2045 T2046 arg1Of Binding,of
R1521 T2045 T2067 arg1Of Binding,triggers
R1522 T2049 T2046 arg2Of ligand,of
R1523 T2049 T2047 arg1Of ligand,the
R1524 T2049 T2048 arg1Of ligand,CD40
R1525 T2049 T2050 arg1Of ligand,(
R1526 T2049 T2053 arg1Of ligand,","
R1527 T2049 T2054 arg1Of ligand,which
R1528 T2049 T2055 arg1Of ligand,is
R1529 T2049 T2057 arg2Of ligand,expressed
R1530 T2051 T2050 arg2Of CD154,(
R1531 T2052 T2050 arg3Of ),(
R1532 T2057 T2055 arg2Of expressed,is
R1533 T2057 T2056 arg1Of expressed,transiently
R1534 T2057 T2058 arg1Of expressed,on
R1535 T2060 T2058 arg2Of surface,on
R1536 T2060 T2059 arg1Of surface,the
R1537 T2060 T2061 arg1Of surface,of
R1538 T2065 T2061 arg2Of cells,of
R1539 T2065 T2062 arg2Of cells,activated
R1540 T2065 T2063 arg1Of cells,CD4+
R1541 T2065 T2064 arg1Of cells,T
R1542 T2067 T2066 arg1Of triggers,","
R1543 T2069 T2067 arg2Of activation,triggers
R1544 T2069 T2068 arg1Of activation,NF-κB
R1545 T2069 T2070 arg1Of activation,resulting
R1546 T2070 T2071 arg1Of resulting,in
R1547 T2073 T2072 arg1Of proliferation,fibroblast
R1548 T2073 T2074 arg1Of proliferation,and
R1549 T2074 T2071 arg2Of and,in
R1550 T2074 T2081 arg1Of and,","
R1551 T2074 T2082 arg1Of and,which
R1552 T2074 T2083 arg1Of and,contributes
R1553 T2075 T2074 arg2Of secretion,and
R1554 T2075 T2076 arg1Of secretion,of
R1555 T2078 T2077 arg1Of cytokines,proinflammatory
R1556 T2078 T2079 arg1Of cytokines,and
R1557 T2079 T2076 arg2Of and,of
R1558 T2080 T2079 arg2Of chemokines,and
R1559 T2083 T2084 arg1Of contributes,to
R1560 T2086 T2084 arg2Of destruction,to
R1561 T2086 T2085 arg1Of destruction,joint
R1562 T2089 T2090 arg1Of studies,with
R1563 T2089 T2096 arg1Of studies,led
R1564 T2089 T2115 arg1Of studies,are
R1565 T2089 T2117 arg2Of studies,required
R1566 T2092 T2091 arg1Of anti-CD40,antagonistic
R1567 T2092 T2093 arg1Of anti-CD40,or
R1568 T2093 T2090 arg2Of or,with
R1569 T2095 T2093 arg2Of antibodies,or
R1570 T2095 T2094 arg1Of antibodies,anti-CD154
R1571 T2096 T2097 arg1Of led,to
R1572 T2096 T2114 arg1Of led,but
R1573 T2099 T2097 arg2Of conclusion,to
R1574 T2099 T2098 arg1Of conclusion,the
R1575 T2102 T2101 arg1Of signals,CD40
R1576 T2102 T2103 arg1Of signals,may
R1577 T2102 T2104 arg1Of signals,be
R1578 T2102 T2105 arg1Of signals,important
R1579 T2104 T2099 arg2Of be,conclusion
R1580 T2104 T2100 arg1Of be,that
R1581 T2104 T2103 arg2Of be,may
R1582 T2105 T2104 arg2Of important,be
R1583 T2105 T2106 arg1Of important,at
R1584 T2109 T2106 arg2Of stages,at
R1585 T2109 T2107 arg1Of stages,the
R1586 T2109 T2108 arg1Of stages,initial
R1587 T2109 T2110 arg1Of stages,of
R1588 T2112 T2110 arg2Of induction,of
R1589 T2112 T2111 arg1Of induction,arthritis
R1590 T2114 T2087 arg1Of but,However
R1591 T2114 T2088 arg1Of but,","
R1592 T2114 T2113 arg1Of but,","
R1593 T2117 T2114 arg2Of required,but
R1594 T2117 T2115 arg2Of required,are
R1595 T2117 T2116 arg1Of required,not
R1596 T2117 T2118 arg1Of required,once
R1597 T2119 T2120 arg1Of disease,is
R1598 T2119 T2121 arg2Of disease,established
R1599 T2121 T2120 arg2Of established,is
R1600 T2121 T2122 arg1Of established,and
R1601 T2122 T2118 arg2Of and,once
R1602 T2124 T2123 arg1Of antibodies,pathogenic
R1603 T2124 T2125 arg1Of antibodies,are
R1604 T2124 T2127 arg1Of antibodies,present
R1605 T2125 T2122 arg2Of are,and
R1606 T2125 T2126 arg1Of are,already
R1607 T2125 T2128 arg1Of are,[
R1608 T2127 T2125 arg2Of present,are
R1609 T2129 T2128 arg2Of "11,12",[
R1610 T2130 T2128 arg3Of ],[
R1611 T2132 T2131 arg2Of expression,Enhanced
R1612 T2132 T2133 arg1Of expression,of
R1613 T2132 T2155 arg1Of expression,is
R1614 T2132 T2157 arg1Of expression,characteristic
R1615 T2139 T2133 arg2Of B-cell,of
R1616 T2139 T2134 arg1Of B-cell,the
R1617 T2139 T2135 arg1Of B-cell,TNF
R1618 T2139 T2136 arg1Of B-cell,receptor
R1619 T2139 T2137 arg1Of B-cell,family
R1620 T2139 T2138 arg1Of B-cell,member
R1621 T2139 T2140 arg1Of B-cell,activating
R1622 T2140 T2145 arg1Of activating,","
R1623 T2140 T2146 modOf activating,allowing
R1624 T2141 T2140 arg2Of factor,activating
R1625 T2141 T2142 arg1Of factor,(
R1626 T2143 T2142 arg2Of BAFF,(
R1627 T2144 T2142 arg3Of ),(
R1628 T2148 T2146 arg2Of survival,allowing
R1629 T2148 T2147 arg1Of survival,the
R1630 T2148 T2149 arg1Of survival,of
R1631 T2148 T2151 arg1Of survival,producing
R1632 T2150 T2149 arg2Of autoantibody-,of
R1633 T2153 T2151 arg2Of lymphocytes,producing
R1634 T2153 T2152 arg1Of lymphocytes,B
R1635 T2155 T2154 arg1Of is,","
R1636 T2155 T2156 arg1Of is,also
R1637 T2155 T2161 arg1Of is,and
R1638 T2157 T2155 arg2Of characteristic,is
R1639 T2157 T2158 arg1Of characteristic,for
R1640 T2159 T2158 arg2Of RA,for
R1641 T2161 T2160 arg1Of and,","
R1642 T2162 T2163 arg1Of antagonists,of
R1643 T2162 T2165 arg1Of antagonists,have
R1644 T2162 T2166 arg1Of antagonists,been
R1645 T2162 T2167 arg2Of antagonists,developed
R1646 T2164 T2163 arg2Of BAFF,of
R1647 T2167 T2161 arg2Of developed,and
R1648 T2167 T2165 arg2Of developed,have
R1649 T2167 T2166 arg2Of developed,been
R1650 T2167 T2168 modOf developed,to
R1651 T2169 T2168 arg1Of counter,to
R1652 T2170 T2169 arg2Of RA,counter
R1653 T2170 T2171 arg1Of RA,[
R1654 T2172 T2171 arg2Of 13,[
R1655 T2173 T2171 arg3Of ],[
R1656 T2179 T2176 arg1Of signalling,lymphotoxin
R1657 T2179 T2177 arg1Of signalling,β
R1658 T2179 T2178 arg1Of signalling,receptor
R1659 T2179 T2180 arg1Of signalling,has
R1660 T2179 T2181 arg1Of signalling,been
R1661 T2179 T2182 arg2Of signalling,implicated
R1662 T2182 T2174 arg1Of implicated,Finally
R1663 T2182 T2175 arg1Of implicated,","
R1664 T2182 T2180 arg2Of implicated,has
R1665 T2182 T2181 arg2Of implicated,been
R1666 T2182 T2183 arg1Of implicated,in
R1667 T2187 T2183 arg2Of formation,in
R1668 T2187 T2184 arg1Of formation,tertiary
R1669 T2187 T2185 arg1Of formation,lymphoid
R1670 T2187 T2186 arg1Of formation,organ
R1671 T2187 T2188 arg1Of formation,at
R1672 T2189 T2188 arg2Of sites,at
R1673 T2189 T2190 arg1Of sites,of
R1674 T2192 T2190 arg2Of inflammation,of
R1675 T2192 T2191 arg1Of inflammation,chronic
R1676 T2192 T2193 arg1Of inflammation,including
R1677 T2194 T2193 arg2Of RA,including
R1678 T2194 T2195 arg1Of RA,[
R1679 T2196 T2195 arg2Of 13,[
R1680 T2197 T2195 arg3Of ],[
R1681 T2199 T2198 arg1Of receptors,Toll-like
R1682 T2199 T2200 arg1Of receptors,(
R1683 T2199 T2203 arg1Of receptors,have
R1684 T2199 T2204 arg1Of receptors,been
R1685 T2199 T2205 arg2Of receptors,implicated
R1686 T2199 T2213 arg1Of receptors,are
R1687 T2201 T2200 arg2Of TLRs,(
R1688 T2202 T2200 arg3Of ),(
R1689 T2205 T2203 arg2Of implicated,have
R1690 T2205 T2204 arg2Of implicated,been
R1691 T2205 T2206 arg1Of implicated,in
R1692 T2205 T2212 arg1Of implicated,and
R1693 T2208 T2206 arg2Of variety,in
R1694 T2208 T2207 arg1Of variety,a
R1695 T2208 T2209 arg1Of variety,of
R1696 T2211 T2209 arg2Of diseases,of
R1697 T2211 T2210 arg1Of diseases,autoimmune
R1698 T2213 T2212 arg2Of are,and
R1699 T2215 T2213 arg2Of candidates,are
R1700 T2215 T2214 arg1Of candidates,potential
R1701 T2215 T2216 arg1Of candidates,for
R1702 T2217 T2216 arg2Of inducing,for
R1703 T2217 T2220 arg1Of inducing,in
R1704 T2219 T2217 arg2Of inflammation,inducing
R1705 T2219 T2218 arg1Of inflammation,NF-κB-dependent
R1706 T2221 T2220 arg2Of RA,in
R1707 T2223 T2222 arg2Of addition,In
R1708 T2223 T2224 arg1Of addition,to
R1709 T2226 T2224 arg2Of ligands,to
R1710 T2226 T2225 arg1Of ligands,microbial
R1711 T2230 T2228 arg1Of number,an
R1712 T2230 T2229 arg1Of number,increasing
R1713 T2230 T2231 arg1Of number,of
R1714 T2230 T2234 arg1Of number,-
R1715 T2230 T2246 arg1Of number,have
R1716 T2230 T2247 arg1Of number,been
R1717 T2230 T2248 arg2Of number,reported
R1718 T2233 T2231 arg2Of ligands,of
R1719 T2233 T2232 arg1Of ligands,endogenous
R1720 T2236 T2234 arg2Of group,-
R1721 T2236 T2235 arg1Of group,a
R1722 T2236 T2237 arg1Of group,of
R1723 T2238 T2237 arg2Of proteins,of
R1724 T2238 T2239 arg2Of proteins,derived
R1725 T2239 T2240 arg1Of derived,from
R1726 T2242 T2241 arg1Of tissues,host
R1727 T2242 T2243 arg1Of tissues,and
R1728 T2243 T2240 arg2Of and,from
R1729 T2244 T2243 arg2Of cells,and
R1730 T2244 T2245 arg1Of cells,-
R1731 T2248 T2222 arg1Of reported,In
R1732 T2248 T2227 arg1Of reported,","
R1733 T2248 T2246 arg2Of reported,have
R1734 T2248 T2247 arg2Of reported,been
R1735 T2248 T2249 arg1Of reported,as
R1736 T2251 T2249 arg2Of activators,as
R1737 T2251 T2250 arg1Of activators,candidate
R1738 T2251 T2252 arg1Of activators,of
R1739 T2253 T2252 arg2Of TLRs,of
R1740 T2253 T2254 arg1Of TLRs,inducing
R1741 T2257 T2254 arg2Of inflammation,inducing
R1742 T2257 T2255 arg1Of inflammation,so-called
R1743 T2257 T2256 arg1Of inflammation,sterile
R1744 T2257 T2258 arg1Of inflammation,(
R1745 T2259 T2258 arg2Of reviewed,(
R1746 T2259 T2260 arg1Of reviewed,in
R1747 T2259 T2261 arg1Of reviewed,[
R1748 T2262 T2261 arg2Of "14,15",[
R1749 T2263 T2261 arg3Of ],[
R1750 T2264 T2258 arg3Of ),(
R1751 T2265 T2266 arg1Of TLRs,are
R1752 T2265 T2267 arg2Of TLRs,expressed
R1753 T2267 T2266 arg2Of expressed,are
R1754 T2267 T2268 arg1Of expressed,in
R1755 T2269 T2268 arg2Of RA,in
R1756 T2271 T2270 arg1Of tissues,synovial
R1757 T2271 T2272 arg1Of tissues,and
R1758 T2272 T2276 arg1Of and,are
R1759 T2272 T2277 arg1Of and,present
R1760 T2275 T2272 arg2Of ligands,and
R1761 T2275 T2273 arg1Of ligands,various
R1762 T2275 T2274 arg1Of ligands,endogenous
R1763 T2276 T2266 modOf are,are
R1764 T2277 T2276 arg2Of present,are
R1765 T2277 T2278 arg1Of present,within
R1766 T2281 T2278 arg2Of joints,within
R1767 T2281 T2279 arg1Of joints,the
R1768 T2281 T2280 arg1Of joints,inflamed
R1769 T2281 T2282 arg1Of joints,of
R1770 T2284 T2282 arg2Of patients,of
R1771 T2284 T2283 arg1Of patients,RA
R1772 T2288 T2287 arg1Of models,animal
R1773 T2288 T2289 arg1Of models,using
R1774 T2288 T2300 arg1Of models,identify
R1775 T2292 T2290 arg1Of mice,TLR
R1776 T2292 T2291 arg1Of mice,knockout
R1777 T2292 T2293 arg1Of mice,or
R1778 T2293 T2289 arg2Of or,using
R1779 T2294 T2293 arg2Of strategies,or
R1780 T2294 T2295 modOf strategies,to
R1781 T2296 T2295 arg1Of block,to
R1782 T2298 T2296 arg2Of signalling,block
R1783 T2298 T2297 arg1Of signalling,TLR
R1784 T2300 T2285 arg1Of identify,Moreover
R1785 T2300 T2286 arg1Of identify,","
R1786 T2300 T2299 arg1Of identify,clearly
R1787 T2300 T2303 arg1Of identify,as
R1788 T2302 T2300 arg2Of inflammation,identify
R1789 T2302 T2301 arg1Of inflammation,TLR-dependent
R1790 T2304 T2303 arg2Of being,as
R1791 T2304 T2306 arg1Of being,in
R1792 T2305 T2304 arg2Of important,being
R1793 T2308 T2306 arg2Of pathogenesis,in
R1794 T2308 T2307 arg1Of pathogenesis,the
R1795 T2308 T2309 arg1Of pathogenesis,of
R1796 T2311 T2309 arg2Of disease,of
R1797 T2311 T2310 arg1Of disease,the
R1798 T2317 T2312 arg1Of protein,High
R1799 T2317 T2313 arg1Of protein,mobility
R1800 T2317 T2314 arg1Of protein,group
R1801 T2317 T2315 arg1Of protein,box
R1802 T2317 T2316 arg1Of protein,chromosomal
R1803 T2317 T2318 arg1Of protein,1
R1804 T2317 T2319 arg1Of protein,(
R1805 T2317 T2322 arg1Of protein,","
R1806 T2317 T2342 arg1Of protein,is
R1807 T2320 T2319 arg2Of HMGB1,(
R1808 T2321 T2319 arg3Of ),(
R1809 T2325 T2324 arg1Of conserved,highly
R1810 T2327 T2322 arg2Of component,","
R1811 T2327 T2323 arg1Of component,a
R1812 T2327 T2325 arg1Of component,conserved
R1813 T2327 T2326 arg1Of component,chromatin
R1814 T2327 T2328 arg1Of component,that
R1815 T2327 T2329 arg1Of component,can
R1816 T2327 T2330 arg1Of component,be
R1817 T2327 T2332 arg2Of component,secreted
R1818 T2327 T2337 arg2Of component,released
R1819 T2332 T2335 arg1Of secreted,or
R1820 T2334 T2332 arg1Of macrophages,secreted
R1821 T2334 T2333 arg2Of macrophages,by
R1822 T2335 T2329 arg2Of or,can
R1823 T2335 T2330 arg2Of or,be
R1824 T2335 T2331 arg1Of or,actively
R1825 T2337 T2335 arg2Of released,or
R1826 T2337 T2336 arg1Of released,passively
R1827 T2340 T2337 arg1Of cells,released
R1828 T2340 T2338 arg2Of cells,by
R1829 T2340 T2339 arg1Of cells,necrotic
R1830 T2342 T2341 arg1Of is,","
R1831 T2343 T2342 arg2Of one,is
R1832 T2343 T2344 arg1Of one,of
R1833 T2348 T2346 arg1Of endogenous,most
R1834 T2348 T2347 arg1Of endogenous,putative
R1835 T2350 T2344 arg2Of ligands,of
R1836 T2350 T2345 arg1Of ligands,the
R1837 T2350 T2348 arg1Of ligands,endogenous
R1838 T2350 T2349 arg1Of ligands,TLR4
R1839 T2350 T2351 arg2Of ligands,involved
R1840 T2351 T2352 arg1Of involved,in
R1841 T2354 T2352 arg2Of pathology,in
R1842 T2354 T2353 arg1Of pathology,RA
R1843 T2355 T2356 arg1Of HMGB1,is
R1844 T2355 T2357 arg2Of HMGB1,increased
R1845 T2357 T2356 arg2Of increased,is
R1846 T2357 T2358 arg1Of increased,in
R1847 T2357 T2374 arg1Of increased,against
R1848 T2361 T2359 arg1Of tissue,RA
R1849 T2361 T2360 arg1Of tissue,synovial
R1850 T2361 T2362 arg1Of tissue,and
R1851 T2362 T2366 arg1Of and,or
R1852 T2365 T2362 arg2Of antibodies,and
R1853 T2365 T2363 arg1Of antibodies,HMGB1
R1854 T2365 T2364 arg1Of antibodies,neutralising
R1855 T2366 T2358 arg2Of or,in
R1856 T2370 T2366 arg2Of domain,or
R1857 T2370 T2367 arg1Of domain,the
R1858 T2370 T2368 arg1Of domain,antagonistic
R1859 T2370 T2369 arg1Of domain,BoxA
R1860 T2370 T2371 arg1Of domain,of
R1861 T2373 T2371 arg2Of protect,of
R1862 T2373 T2372 arg1Of protect,HMGB1
R1863 T2376 T2374 arg2Of arthritis,against
R1864 T2376 T2375 arg1Of arthritis,collagen-induced
R1865 T2376 T2377 arg1Of arthritis,in
R1866 T2378 T2377 arg2Of mice,in
R1867 T2378 T2379 arg1Of mice,[
R1868 T2380 T2379 arg2Of 16,[
R1869 T2381 T2379 arg3Of ],[
R1870 T2383 T2382 arg1Of protein,Myeloid-related
R1871 T2383 T2384 arg1Of protein,8
R1872 T2383 T2385 arg1Of protein,and
R1873 T2385 T2389 arg1Of and,","
R1874 T2385 T2403 arg1Of and,are
R1875 T2385 T2406 arg1Of and,present
R1876 T2385 T2413 arg1Of and,have
R1877 T2385 T2414 arg1Of and,been
R1878 T2385 T2415 arg2Of and,suggested
R1879 T2385 T2417 arg1Of and,be
R1880 T2385 T2418 arg2Of and,involved
R1881 T2387 T2385 arg2Of protein,and
R1882 T2387 T2386 arg1Of protein,myeloid-related
R1883 T2387 T2388 arg1Of protein,14
R1884 T2393 T2389 arg2Of molecules,","
R1885 T2393 T2390 arg1Of molecules,damage-associated
R1886 T2393 T2391 arg1Of molecules,molecular
R1887 T2393 T2392 arg1Of molecules,pattern
R1888 T2393 T2394 arg1Of molecules,belonging
R1889 T2394 T2395 arg1Of belonging,to
R1890 T2398 T2395 arg2Of family,to
R1891 T2398 T2396 arg1Of family,the
R1892 T2398 T2397 arg1Of family,S100
R1893 T2398 T2399 arg1Of family,of
R1894 T2401 T2399 arg2Of proteins,of
R1895 T2401 T2400 arg1Of proteins,calcium-binding
R1896 T2403 T2404 arg1Of are,also
R1897 T2403 T2412 arg1Of are,and
R1898 T2406 T2403 arg2Of present,are
R1899 T2406 T2405 arg1Of present,abundantly
R1900 T2406 T2407 arg1Of present,in
R1901 T2410 T2407 arg2Of fluid,in
R1902 T2410 T2408 arg1Of fluid,RA
R1903 T2410 T2409 arg1Of fluid,synovial
R1904 T2412 T2402 arg1Of and,","
R1905 T2412 T2411 arg1Of and,","
R1906 T2415 T2412 arg2Of suggested,and
R1907 T2415 T2413 arg2Of suggested,have
R1908 T2415 T2414 arg2Of suggested,been
R1909 T2418 T2415 arg3Of involved,suggested
R1910 T2418 T2416 arg1Of involved,to
R1911 T2418 T2417 arg2Of involved,be
R1912 T2418 T2419 arg1Of involved,in
R1913 T2418 T2423 arg1Of involved,in
R1914 T2422 T2419 arg2Of inflammation,in
R1915 T2422 T2420 arg1Of inflammation,TLR4-induced
R1916 T2422 T2421 arg1Of inflammation,chronic
R1917 T2424 T2423 arg2Of RA,in
R1918 T2424 T2425 arg1Of RA,[
R1919 T2426 T2425 arg2Of "17,18",[
R1920 T2427 T2425 arg3Of ],[
R1921 T2431 T2428 arg1Of ligands,Other
R1922 T2431 T2429 arg1Of ligands,endogenous
R1923 T2431 T2430 arg1Of ligands,TLR
R1924 T2431 T2432 arg1Of ligands,that
R1925 T2431 T2433 arg1Of ligands,may
R1926 T2431 T2434 arg1Of ligands,be
R1927 T2431 T2435 arg2Of ligands,involved
R1928 T2431 T2439 arg1Of ligands,are
R1929 T2435 T2433 arg2Of involved,may
R1930 T2435 T2434 arg2Of involved,be
R1931 T2435 T2436 arg1Of involved,in
R1932 T2438 T2436 arg2Of pathology,in
R1936 T2442 T2444 arg1Of components,as
R1937 T2442 T2454 arg1Of components,and
R1938 T2444 T2443 arg1Of as,such
R1939 T2445 T2446 arg1Of fibrinogen,","
R1940 T2446 T2448 arg1Of ",",","
R1941 T2447 T2446 arg2Of fibronectin,","
R1942 T2448 T2450 arg1Of ",",","
R1943 T2449 T2448 arg2Of biglycan,","
R1944 T2450 T2444 arg2Of ",",as
R1945 T2452 T2450 arg2Of C,","
R1946 T2452 T2451 arg1Of C,tenascin
R1947 T2454 T2439 arg2Of and,are
R1948 T2454 T2453 arg1Of and,","
R1949 T2457 T2454 arg2Of fragments,and
R1950 T2457 T2455 arg1Of fragments,hyal-uronic
R1951 T2457 T2456 arg1Of fragments,acid
R1952 T2457 T2458 arg1Of fragments,(
R1953 T2459 T2458 arg2Of reviewed,(
R1954 T2459 T2460 arg1Of reviewed,in
R1955 T2459 T2461 arg1Of reviewed,[
R1956 T2462 T2461 arg2Of "14,15",[
R1957 T2463 T2461 arg3Of ],[
R1958 T2464 T2458 arg3Of ),(
R1959 T2468 T2467 arg1Of studies,these
R1960 T2468 T2469 arg1Of studies,suggest
R1961 T2469 T2465 arg1Of suggest,Together
R1962 T2469 T2466 arg1Of suggest,","
R1963 T2473 T2471 arg1Of ligands,several
R1964 T2473 T2472 arg1Of ligands,TLR
R1965 T2473 T2474 arg1Of ligands,in
R1966 T2473 T2479 arg1Of ligands,may
R1967 T2473 T2480 arg1Of ligands,contribute
R1968 T2478 T2474 arg2Of tissue,in
R1969 T2478 T2475 arg1Of tissue,the
R1970 T2478 T2476 arg1Of tissue,inflamed
R1971 T2478 T2477 arg1Of tissue,joint
R1972 T2480 T2469 arg2Of contribute,suggest
R1973 T2480 T2470 arg1Of contribute,that
R1974 T2480 T2479 arg2Of contribute,may
R1975 T2480 T2481 arg1Of contribute,to
R1976 T2483 T2482 arg1Of activation,NF-κB
R1977 T2483 T2484 arg1Of activation,and
R1978 T2484 T2481 arg2Of and,to
R1979 T2484 T2488 arg1Of and,in
R1980 T2487 T2484 arg2Of expression,and
R1981 T2487 T2485 arg1Of expression,inflammatory
R1982 T2487 T2486 arg1Of expression,gene
R1983 T2489 T2488 arg2Of RA,in
R3033 T4573 T4572 arg1Of proteins,NF-κB
R3034 T4573 T4574 arg1Of proteins,are
R3035 T4573 T4575 arg2Of proteins,sequestered
R3036 T4575 T4574 arg2Of sequestered,are
R3037 T4575 T4576 arg1Of sequestered,in
R3038 T4575 T4579 arg1Of sequestered,as
R3039 T4575 T4587 arg1Of sequestered,as
R3040 T4578 T4576 arg2Of cytoplasm,in
R3041 T4578 T4577 arg1Of cytoplasm,the
R3042 T4581 T4579 arg2Of complexes,as
R3043 T4581 T4580 arg1Of complexes,latent
R3044 T4584 T4575 arg1Of proteins,sequestered
R3045 T4584 T4582 arg2Of proteins,by
R3046 T4584 T4583 arg1Of proteins,inhibitory
R3047 T4584 T4585 arg2Of proteins,referred
R3048 T4585 T4586 arg1Of referred,to
R3049 T4588 T4587 arg2Of inhibitor,as
R3050 T4588 T4589 arg1Of inhibitor,of
R3051 T4592 T4591 arg2Of IκB,(
R3052 T4593 T4591 arg3Of ),(
R3053 T4594 T4589 arg2Of proteins,of
R3054 T4594 T4590 arg1Of proteins,NF-κB
R3055 T4594 T4591 arg1Of proteins,(
R3056 T4594 T4595 arg1Of proteins,","
R3057 T4594 T4596 arg1Of proteins,which
R3058 T4594 T4597 arg1Of proteins,prevent
R3059 T4600 T4598 arg1Of translocation,NF-κB
R3060 T4600 T4599 arg1Of translocation,nuclear
R3061 T4600 T4601 arg1Of translocation,and
R3062 T4601 T4597 arg2Of and,prevent
R3063 T4603 T4601 arg2Of binding,and
R3064 T4603 T4602 arg1Of binding,DNA
R3065 T4603 T4604 arg1Of binding,[
R3066 T4605 T4604 arg2Of 19,[
R3067 T4606 T4604 arg3Of ],[
R3068 T4609 T4608 arg1Of majority,the
R3069 T4609 T4610 arg1Of majority,of
R3070 T4609 T4635 arg1Of majority,serve
R3071 T4611 T4610 arg2Of IκBs,of
R3072 T4611 T4612 arg1Of IκBs,(
R3073 T4613 T4614 arg1Of IκBα,","
R3074 T4614 T4616 arg1Of ",",","
R3075 T4615 T4614 arg2Of IκBβ,","
R3076 T4616 T4618 arg1Of ",",","
R3077 T4617 T4616 arg2Of IκBε,","
R3078 T4618 T4612 arg2Of ",",(
R3079 T4618 T4626 arg1Of ",",","
R3080 T4619 T4618 arg2Of p105,","
R3081 T4619 T4620 arg1Of p105,(
R3082 T4622 T4620 arg2Of known,(
R3083 T4622 T4621 arg1Of known,also
R3084 T4622 T4623 arg1Of known,as
R3085 T4624 T4623 arg2Of NF-κB1,as
R3086 T4625 T4620 arg3Of ),(
R3087 T4627 T4626 arg2Of p100,","
R3088 T4627 T4628 arg1Of p100,(
R3089 T4630 T4628 arg2Of known,(
R3090 T4630 T4629 arg1Of known,also
R3091 T4630 T4631 arg1Of known,as
R3092 T4632 T4631 arg2Of NF-κB2,as
R3093 T4633 T4628 arg3Of ),(
R3094 T4634 T4612 arg3Of ),(
R3095 T4635 T4607 arg2Of serve,Whereas
R3096 T4635 T4636 arg1Of serve,as
R3097 T4637 T4636 arg2Of inhibitors,as
R3098 T4637 T4638 arg1Of inhibitors,of
R3099 T4639 T4638 arg2Of NF-κB,of
R3100 T4641 T4642 arg1Of IκBξ,and
R3101 T4642 T4645 arg1Of and,potentiate
R3102 T4643 T4642 arg2Of Bcl-3,and
R3103 T4645 T4644 arg1Of potentiate,instead
R3104 T4645 T4652 arg1Of potentiate,and
R3105 T4647 T4645 arg2Of transactivation,potentiate
R3106 T4647 T4646 arg1Of transactivation,NF-κB
R3107 T4647 T4648 arg1Of transactivation,in
R3108 T4651 T4648 arg2Of p100,in
R3109 T4651 T4649 arg1Of p100,the
R3110 T4651 T4650 arg1Of p100,nucleus.
R3111 T4652 T4607 arg1Of and,Whereas
R3112 T4652 T4640 arg1Of and,","
R3113 T4653 T4654 arg1Of p105,are
R3114 T4654 T4652 arg2Of are,and
R3115 T4654 T4663 arg1Of are,","
R3116 T4654 T4664 arg1Of are,respectively
R3117 T4655 T4654 arg2Of precursors,are
R3118 T4655 T4656 arg1Of precursors,of
R3119 T4658 T4659 arg1Of p52,and
R3120 T4660 T4659 arg2Of p50,and
R3121 T4662 T4656 arg2Of subunits,of
R3122 T4662 T4657 arg1Of subunits,the
R3123 T4662 T4658 arg1Of subunits,p52
R3124 T4662 T4660 arg1Of subunits,p50
R3125 T4662 T4661 arg1Of subunits,NF-κB
R3126 T4665 T4666 arg1Of There,are
R3127 T4671 T4666 arg2Of pathways,are
R3128 T4671 T4667 arg1Of pathways,two
R3129 T4671 T4668 arg1Of pathways,unique
R3130 T4671 T4669 arg1Of pathways,NF-κB
R3131 T4671 T4670 arg1Of pathways,signalling
R3132 T4671 T4672 arg1Of pathways,","
R3133 T4671 T4673 arg2Of pathways,termed
R3134 T4674 T4675 arg1Of canonical,(
R3135 T4674 T4679 arg1Of canonical,and
R3136 T4677 T4675 arg2Of classical,(
R3137 T4677 T4676 arg1Of classical,or
R3138 T4678 T4675 arg3Of ),(
R3139 T4680 T4681 arg1Of noncanonical,(
R3140 T4680 T4682 arg1Of noncanonical,or
R3141 T4682 T4679 arg2Of or,and
R3142 T4685 T4682 arg2Of NF-κB,or
R3143 T4685 T4683 arg1Of NF-κB,alternative
R3144 T4685 T4684 arg1Of NF-κB,)
R3145 T4686 T4673 arg3Of pathways,termed
R3146 T4686 T4674 arg1Of pathways,canonical
R3147 T4686 T4680 arg1Of pathways,noncanonical
R3148 T4686 T4685 arg1Of pathways,NF-κB
R3149 T4690 T4687 arg1Of pathway,The
R3150 T4690 T4688 arg1Of pathway,canonical
R3151 T4690 T4689 arg1Of pathway,NF-κB
R3152 T4690 T4691 arg1Of pathway,plays
R3153 T4690 T4702 arg1Of pathway,is
R3154 T4690 T4703 arg2Of pathway,triggered
R3155 T4691 T4695 arg1Of plays,in
R3156 T4691 T4701 arg1Of plays,and
R3157 T4694 T4691 arg2Of role,plays
R3158 T4694 T4692 arg1Of role,a
R3159 T4694 T4693 arg1Of role,major
R3160 T4696 T4697 arg1Of innate,and
R3161 T4698 T4697 arg2Of adaptive,and
R3162 T4699 T4695 arg2Of immunity,in
R3163 T4699 T4696 arg1Of immunity,innate
R3164 T4699 T4698 arg1Of immunity,adaptive
R3165 T4701 T4700 arg1Of and,","
R3166 T4703 T4701 arg2Of triggered,and
R3167 T4703 T4702 arg2Of triggered,is
R3168 T4706 T4703 arg1Of stimuli,triggered
R3169 T4706 T4704 arg2Of stimuli,by
R3170 T4706 T4705 arg1Of stimuli,many
R3171 T4706 T4707 arg1Of stimuli,including
R3172 T4709 T4708 arg1Of cytokines,proinflammatory
R3173 T4709 T4710 arg1Of cytokines,(
R3174 T4709 T4718 arg1Of cytokines,","
R3175 T4711 T4710 arg2Of for,(
R3176 T4712 T4713 arg1Of example,","
R3177 T4713 T4715 arg1Of ",",","
R3178 T4714 T4713 arg2Of TNF,","
R3179 T4715 T4711 arg2Of ",",for
R3180 T4716 T4715 arg2Of IL-1,","
R3181 T4717 T4710 arg3Of ),(
R3182 T4718 T4707 arg2Of ",",including
R3183 T4719 T4720 arg1Of antigens,","
R3184 T4720 T4723 arg1Of ",",and
R3185 T4721 T4720 arg2Of RANKL,","
R3186 T4723 T4718 arg2Of and,","
R3187 T4723 T4722 arg1Of and,","
R3188 T4725 T4723 arg2Of ligands,and
R3189 T4725 T4724 arg1Of ligands,TLR
R3190 T4727 T4726 arg1Of signalling,NF-κB
R3191 T4727 T4728 arg2Of signalling,initiated
R3192 T4727 T4732 arg1Of signalling,requires
R3193 T4731 T4728 arg1Of receptors,initiated
R3194 T4731 T4729 arg2Of receptors,by
R3195 T4731 T4730 arg1Of receptors,different
R3196 T4734 T4732 arg2Of formation,requires
R3197 T4734 T4733 arg1Of formation,the
R3198 T4734 T4735 arg1Of formation,of
R3199 T4734 T4759 arg1Of formation,","
R3200 T4734 T4760 arg1Of formation,which
R3201 T4734 T4761 arg1Of formation,mediates
R3202 T4738 T4735 arg2Of interactions,of
R3203 T4738 T4736 arg1Of interactions,proximal
R3204 T4738 T4737 arg1Of interactions,protein-protein
R3205 T4738 T4739 arg1Of interactions,that
R3206 T4738 T4740 arg1Of interactions,are
R3207 T4738 T4743 arg1Of interactions,specific
R3208 T4738 T4747 arg1Of interactions,converge
R3209 T4740 T4741 arg1Of are,often
R3210 T4740 T4745 arg1Of are,but
R3211 T4743 T4740 arg2Of specific,are
R3212 T4743 T4742 arg1Of specific,receptor
R3213 T4745 T4744 arg1Of but,","
R3214 T4747 T4745 arg2Of converge,but
R3215 T4747 T4746 arg1Of converge,ultimately
R3216 T4747 T4748 arg1Of converge,in
R3217 T4750 T4748 arg2Of activation,in
R3218 T4750 T4749 arg1Of activation,the
R3219 T4750 T4751 arg1Of activation,of
R3220 T4754 T4753 arg1Of kinase,IκB
R3221 T4754 T4755 arg1Of kinase,(
R3222 T4756 T4755 arg2Of IKK,(
R3223 T4757 T4755 arg3Of ),(
R3224 T4758 T4751 arg2Of complex,of
R3225 T4758 T4752 arg1Of complex,the
R3226 T4758 T4754 arg1Of complex,kinase
R3227 T4762 T4761 arg2Of phosphorylation,mediates
R3228 T4762 T4763 arg1Of phosphorylation,of
R3229 T4767 T4763 arg2Of protein,of
R3230 T4767 T4764 arg1Of protein,the
R3231 T4767 T4765 arg1Of protein,inhibitory
R3232 T4767 T4766 arg1Of protein,IκB
R3233 T4767 T4768 arg1Of protein,leading
R3234 T4768 T4769 arg1Of leading,to
R3235 T4768 T4777 arg1Of leading,[
R3236 T4771 T4772 arg1Of K48-polyubiquitination,and
R3237 T4772 T4769 arg2Of and,to
R3238 T4772 T4770 arg1Of and,its
R3239 T4772 T4774 arg1Of and,by
R3240 T4773 T4772 arg2Of degradation,and
R3241 T4776 T4774 arg2Of proteasome,by
R3242 T4776 T4775 arg1Of proteasome,the
R3243 T4778 T4777 arg2Of 20,[
R3244 T4779 T4777 arg3Of ],[
R3245 T4782 T4780 arg1Of complex,The
R3246 T4782 T4781 arg1Of complex,IKK
R3247 T4782 T4783 arg1Of complex,is
R3248 T4782 T4784 arg2Of complex,comprised
R3249 T4784 T4783 arg2Of comprised,is
R3250 T4784 T4785 arg1Of comprised,of
R3251 T4784 T4816 arg1Of comprised,(
R3252 T4789 T4787 arg1Of subunits,two
R3253 T4789 T4788 arg1Of subunits,catalytic
R3254 T4790 T4791 arg1Of IKK1,and
R3255 T4791 T4786 arg1Of and,the
R3256 T4791 T4789 arg1Of and,subunits
R3257 T4791 T4793 arg1Of and,(
R3258 T4791 T4801 arg1Of and,and
R3259 T4792 T4791 arg2Of IKK2,and
R3260 T4795 T4793 arg2Of known,(
R3261 T4795 T4794 arg1Of known,also
R3262 T4795 T4796 arg1Of known,as
R3263 T4797 T4798 arg1Of IKKα,and
R3264 T4798 T4796 arg2Of and,as
R3265 T4799 T4798 arg2Of IKKβ,and
R3266 T4800 T4793 arg3Of ),(
R3267 T4801 T4785 arg2Of and,of
R3268 T4807 T4801 arg2Of modulator,and
R3269 T4807 T4802 arg1Of modulator,the
R3270 T4807 T4803 arg1Of modulator,regulatory
R3271 T4807 T4804 arg1Of modulator,subunit
R3272 T4807 T4805 arg1Of modulator,NF-κB
R3273 T4807 T4806 arg1Of modulator,essential
R3274 T4807 T4808 arg1Of modulator,(
R3275 T4809 T4808 arg2Of NEMO,(
R3276 T4809 T4810 arg1Of NEMO,-
R3277 T4809 T4812 arg2Of NEMO,known
R3278 T4812 T4811 arg1Of known,also
R3279 T4812 T4813 arg1Of known,as
R3280 T4814 T4813 arg2Of IKKγ,as
R3281 T4815 T4808 arg3Of ),(
R3282 T4817 T4816 arg2Of Figure,(
R3283 T4817 T4818 arg1Of Figure,1
R3284 T4819 T4816 arg3Of ),(
R3285 T4820 T4821 arg1Of Gene,targeting
R3286 T4820 T4823 arg1Of Gene,showed
R3287 T4822 T4821 arg2Of experiments,targeting
R3288 T4825 T4826 arg1Of IKK2,and
R3289 T4826 T4829 arg1Of and,but
R3290 T4827 T4826 arg2Of NEMO,and
R3291 T4829 T4828 arg1Of but,","
R3292 T4829 T4830 arg1Of but,not
R3293 T4829 T4833 arg1Of but,are
R3294 T4829 T4834 arg2Of but,required
R3295 T4831 T4829 arg2Of IKK1,but
R3296 T4834 T4823 arg2Of required,showed
R3297 T4834 T4824 arg1Of required,that
R3298 T4834 T4832 arg1Of required,","
R3299 T4834 T4833 arg2Of required,are
R3300 T4834 T4835 arg1Of required,for
R3301 T4834 T4839 arg1Of required,[
R3302 T4838 T4835 arg2Of activation,for
R3303 T4838 T4836 arg1Of activation,canonical
R3304 T4838 T4837 arg1Of activation,NF-κB
R3305 T4840 T4839 arg2Of 21,[
R3306 T4841 T4839 arg3Of ],[
R3307 T4842 T4843 arg1Of One,of
R3308 T4842 T4850 arg1Of One,is
R3309 T4846 T4845 arg1Of studied,best
R3310 T4849 T4843 arg2Of pathways,of
R3311 T4849 T4844 arg1Of pathways,the
R3312 T4849 T4846 arg1Of pathways,studied
R3313 T4849 T4847 arg1Of pathways,NF-κB
R3314 T4849 T4848 arg1Of pathways,signalling
R3315 T4853 T4850 arg2Of pathway,is
R3316 T4853 T4851 arg1Of pathway,the
R3317 T4853 T4852 arg1Of pathway,TNF
R3318 T4855 T4854 arg1Of stimulation,TNF
R3319 T4855 T4856 arg1Of stimulation,results
R3320 T4856 T4857 arg1Of results,in
R3321 T4859 T4860 arg1Of recruitment,of
R3322 T4859 T4870 arg1Of recruitment,of
R3323 T4859 T4878 arg1Of recruitment,","
R3324 T4859 T4879 arg1Of recruitment,which
R3325 T4859 T4880 arg1Of recruitment,function
R3326 T4859 T4896 arg1Of recruitment,and
R3327 T4860 T4869 arg1Of of,and
R3328 T4864 T4861 arg1Of domain,TNF
R3329 T4864 T4862 arg1Of domain,receptor-1-associated
R3330 T4864 T4863 arg1Of domain,death
R3331 T4864 T4865 arg1Of domain,(
R3332 T4866 T4865 arg2Of TRADD,(
R3333 T4867 T4865 arg3Of ),(
R3334 T4868 T4860 arg2Of protein,of
R3335 T4868 T4864 arg1Of protein,domain
R3336 T4870 T4869 arg2Of of,and
R3337 T4873 T4870 arg2Of protein,of
R3338 T4873 T4871 arg1Of protein,receptor
R3339 T4873 T4872 arg1Of protein,interacting
R3340 T4873 T4874 arg1Of protein,1
R3341 T4873 T4875 arg1Of protein,(
R3342 T4876 T4875 arg2Of RIP1,(
R3343 T4877 T4875 arg3Of ),(
R3344 T4880 T4881 arg1Of function,as
R3345 T4883 T4881 arg2Of proteins,as
R3346 T4883 T4882 arg1Of proteins,adaptor
R3347 T4883 T4884 arg1Of proteins,for
R3348 T4891 T4884 arg2Of factor,for
R3349 T4891 T4885 arg1Of factor,the
R3350 T4891 T4886 arg1Of factor,E3
R3351 T4891 T4887 arg1Of factor,ubiquitin
R3352 T4891 T4888 arg1Of factor,ligases
R3353 T4891 T4889 arg1Of factor,TNF
R3354 T4891 T4890 arg1Of factor,receptor-associated
R3355 T4891 T4892 arg1Of factor,(
R3356 T4891 T4895 arg1Of factor,2
R3357 T4893 T4892 arg2Of TRAF,(
R3358 T4894 T4892 arg3Of ),(
R3359 T4896 T4857 arg2Of and,in
R3360 T4896 T4858 arg1Of and,the
R3361 T4897 T4896 arg2Of TRAF5,and
R3362 T4897 T4898 arg1Of TRAF5,","
R3363 T4897 T4899 arg1Of TRAF5,which
R3364 T4897 T4902 arg1Of TRAF5,bind
R3365 T4901 T4900 arg2Of turn,in
R3366 T4902 T4900 arg1Of bind,in
R3367 T4908 T4902 arg2Of inhibitor,bind
R3368 T4908 T4903 arg1Of inhibitor,the
R3369 T4908 T4904 arg1Of inhibitor,E3
R3370 T4908 T4905 arg1Of inhibitor,ubiquitin
R3371 T4908 T4906 arg1Of inhibitor,ligases
R3372 T4908 T4907 arg1Of inhibitor,cellular
R3373 T4908 T4909 arg1Of inhibitor,of
R3374 T4910 T4911 arg1Of apoptosis,(
R3375 T4910 T4914 arg1Of apoptosis,1
R3376 T4910 T4915 arg1Of apoptosis,and
R3377 T4912 T4911 arg2Of cIAP,(
R3378 T4913 T4911 arg3Of ),(
R3379 T4915 T4909 arg2Of and,of
R3380 T4916 T4915 arg2Of cIAP2,and
R3381 T4916 T4917 arg1Of cIAP2,(
R3382 T4918 T4917 arg2Of Figure,(
R3383 T4918 T4919 arg1Of Figure,1
R3384 T4920 T4917 arg3Of ),(
R3385 T4923 T4921 arg2Of stimulation,On
R3386 T4923 T4922 arg1Of stimulation,TNF
R3387 T4925 T4926 arg1Of TNF-receptor,bound
R3388 T4926 T4921 arg1Of bound,On
R3389 T4926 T4924 arg1Of bound,","
R3390 T4927 T4928 arg1Of RIP1,is
R3391 T4927 T4930 arg2Of RIP1,modified
R3392 T4930 T4926 arg2Of modified,bound
R3393 T4930 T4928 arg2Of modified,is
R3394 T4930 T4929 arg1Of modified,rapidly
R3395 T4934 T4930 arg1Of chains,modified
R3396 T4934 T4931 arg2Of chains,by
R3397 T4934 T4932 arg1Of chains,K63-linked
R3398 T4934 T4933 arg1Of chains,polyubiquitin
R3399 T4935 T4936 arg1Of TRAF2/5,and
R3400 T4936 T4938 arg1Of and,are
R3401 T4937 T4936 arg2Of cIAP1/2,and
R3402 T4938 T4945 arg1Of are,but
R3403 T4940 T4938 arg2Of candidates,are
R3404 T4940 T4939 arg1Of candidates,good
R3405 T4940 T4941 arg1Of candidates,for
R3406 T4943 T4941 arg2Of ubiquitination,for
R3407 T4943 T4942 arg1Of ubiquitination,RIP1
R3408 T4945 T4944 arg1Of but,","
R3409 T4948 T4946 arg1Of role,the
R3410 T4948 T4947 arg1Of role,specific
R3411 T4948 T4949 arg1Of role,of
R3412 T4948 T4951 arg1Of role,is
R3413 T4948 T4953 arg1Of role,unclear
R3414 T4950 T4949 arg2Of each,of
R3415 T4951 T4945 arg2Of is,but
R3416 T4951 T4952 arg1Of is,still
R3417 T4953 T4951 arg2Of unclear,is
R3418 T4956 T4954 arg1Of chains,The
R3419 T4956 T4955 arg1Of chains,polyubiquitin
R3420 T4956 T4957 arg1Of chains,on
R3421 T4956 T4959 arg1Of chains,are
R3422 T4956 T4960 arg2Of chains,believed
R3423 T4956 T4962 arg1Of chains,create
R3424 T4958 T4957 arg2Of RIP1,on
R3425 T4960 T4959 arg2Of believed,are
R3426 T4962 T4960 arg3Of create,believed
R3427 T4962 T4961 arg1Of create,to
R3428 T4964 T4962 arg2Of scaffold,create
R3429 T4964 T4963 arg1Of scaffold,a
R3430 T4964 T4965 modOf scaffold,to
R3431 T4966 T4965 arg1Of recruit,to
R3432 T4966 T4979 arg1Of recruit,","
R3433 T4966 T4980 arg1Of recruit,respectively
R3434 T4968 T4969 arg1Of IKK,and
R3435 T4970 T4969 arg2Of TAK1,and
R3436 T4971 T4966 arg2Of complex,recruit
R3437 T4971 T4967 arg1Of complex,the
R3438 T4971 T4968 arg1Of complex,IKK
R3439 T4971 T4970 arg1Of complex,TAK1
R3440 T4971 T4972 arg1Of complex,via
R3441 T4975 T4973 arg1Of proteins,the
R3442 T4975 T4974 arg1Of proteins,ubiquitin-binding
R3443 T4976 T4977 arg1Of NEMO,and
R3444 T4977 T4972 arg2Of and,via
R3445 T4977 T4975 arg1Of and,proteins
R3446 T4978 T4977 arg2Of TAB1/2,and
R3447 T4983 T4981 arg1Of identification,The
R3448 T4983 T4982 arg1Of identification,recent
R3449 T4983 T4984 arg1Of identification,of
R3450 T4983 T5004 arg1Of identification,adds
R3451 T4989 T4984 arg2Of complex,of
R3452 T4989 T4985 arg1Of complex,a
R3453 T4989 T4986 arg1Of complex,distinct
R3454 T4989 T4987 arg1Of complex,E2/E3
R3455 T4989 T4988 arg1Of complex,enzyme
R3456 T4989 T4990 arg1Of complex,that
R3457 T4989 T4991 arg1Of complex,modifies
R3458 T4989 T4998 arg1Of complex,is
R3459 T4989 T4999 arg1Of complex,essential
R3460 T4991 T4997 arg1Of modifies,and
R3461 T4992 T4991 arg2Of NEMO,modifies
R3462 T4992 T4993 arg1Of NEMO,with
R3463 T4996 T4993 arg2Of chains,with
R3464 T4996 T4994 arg1Of chains,linear
R3465 T4996 T4995 arg1Of chains,polyubiquitin
R3466 T4998 T4997 arg2Of is,and
R3467 T4999 T4998 arg2Of essential,is
R3468 T4999 T5000 arg1Of essential,for
R3469 T5003 T5000 arg2Of signalling,for
R3470 T5003 T5001 arg1Of signalling,TNF-activated
R3471 T5003 T5002 arg1Of signalling,NF-κB
R3472 T5006 T5004 arg2Of complexity,adds
R3473 T5006 T5005 arg1Of complexity,further
R3474 T5006 T5007 arg1Of complexity,[
R3475 T5008 T5007 arg2Of 22,[
R3476 T5009 T5007 arg3Of ],[
R3477 T5012 T5010 arg1Of role,The
R3478 T5012 T5011 arg1Of role,exact
R3479 T5012 T5013 arg1Of role,of
R3480 T5012 T5017 arg1Of role,remains
R3481 T5012 T5018 arg1Of role,unclear
R3482 T5016 T5013 arg2Of chains,of
R3483 T5016 T5014 arg1Of chains,protein-anchored
R3484 T5016 T5015 arg1Of chains,polyubiquitin
R3485 T5017 T5019 arg1Of remains,","
R3486 T5017 T5020 arg1Of remains,as
R3487 T5018 T5017 arg2Of unclear,remains
R3488 T5021 T5022 arg1Of it,was
R3489 T5021 T5024 arg2Of it,suggested
R3490 T5024 T5020 arg2Of suggested,as
R3491 T5024 T5022 arg2Of suggested,was
R3492 T5024 T5023 arg1Of suggested,recently
R3493 T5028 T5026 arg1Of chains,unanchored
R3494 T5028 T5027 arg1Of chains,polyubiquitin
R3495 T5028 T5029 arg1Of chains,can
R3496 T5028 T5031 arg1Of chains,activate
R3497 T5031 T5024 arg3Of activate,suggested
R3498 T5031 T5025 arg1Of activate,that
R3499 T5031 T5029 arg2Of activate,can
R3500 T5031 T5030 arg1Of activate,directly
R3501 T5031 T5035 arg1Of activate,[
R3502 T5034 T5031 arg2Of complex,activate
R3503 T5034 T5032 arg1Of complex,the
R3504 T5034 T5033 arg1Of complex,TAK1
R3505 T5036 T5035 arg2Of 23,[
R3506 T5037 T5035 arg3Of ],[
R3507 T5040 T5038 arg1Of principles,Similar
R3508 T5040 T5039 arg1Of principles,signalling
R3509 T5040 T5041 arg1Of principles,apply
R3510 T5041 T5042 arg1Of apply,to
R3511 T5044 T5042 arg2Of receptors,to
R3512 T5044 T5043 arg1Of receptors,other
R3513 T5046 T5045 arg2Of example,For
R3514 T5049 T5048 arg1Of stimulation,TLR4
R3515 T5049 T5050 arg1Of stimulation,by
R3516 T5049 T5052 arg1Of stimulation,induces
R3517 T5051 T5050 arg2Of lipopolysaccharide,by
R3518 T5052 T5045 arg1Of induces,For
R3519 T5052 T5047 arg1Of induces,","
R3520 T5054 T5052 arg2Of recruitment,induces
R3521 T5054 T5053 arg1Of recruitment,the
R3522 T5054 T5055 arg1Of recruitment,of
R3523 T5059 T5056 arg1Of protein,Toll/IL-1
R3524 T5059 T5057 arg1Of protein,receptor
R3525 T5059 T5058 arg1Of protein,adaptor
R3526 T5059 T5060 arg1Of protein,(
R3527 T5059 T5067 arg1Of protein,and
R3528 T5062 T5060 arg2Of referred,(
R3529 T5062 T5061 arg1Of referred,also
R3530 T5062 T5063 arg1Of referred,to
R3531 T5062 T5064 arg1Of referred,as
R3532 T5065 T5064 arg2Of Mal,as
R3533 T5066 T5060 arg3Of ),(
R3534 T5067 T5055 arg2Of and,of
R3535 T5067 T5074 arg1Of and,","
R3536 T5067 T5075 arg1Of and,which
R3537 T5067 T5078 arg1Of and,serve
R3538 T5067 T5080 arg1Of and,bridging
R3539 T5070 T5067 arg2Of molecule,and
R3540 T5070 T5068 arg1Of molecule,TRIF-related
R3541 T5070 T5069 arg1Of molecule,adaptor
R3542 T5070 T5071 arg1Of molecule,(
R3543 T5072 T5071 arg2Of TRAM,(
R3544 T5073 T5071 arg3Of ),(
R3545 T5077 T5076 arg1Of probably,most
R3546 T5078 T5077 arg1Of serve,probably
R3547 T5078 T5079 arg1Of serve,as
R3548 T5080 T5079 arg2Of bridging,as
R3549 T5081 T5080 arg2Of factors,bridging
R3550 T5081 T5083 arg1Of factors,recruit
R3551 T5083 T5080 arg3Of recruit,bridging
R3552 T5083 T5082 arg1Of recruit,to
R3553 T5083 T5101 arg1Of recruit,","
R3554 T5083 T5102 arg1Of recruit,respectively
R3555 T5086 T5084 arg1Of primary,myeloid
R3556 T5086 T5085 arg1Of primary,differentiation
R3557 T5088 T5087 arg1Of gene,response
R3558 T5088 T5089 arg1Of gene,88
R3559 T5088 T5090 arg1Of gene,(
R3560 T5088 T5093 arg1Of gene,and
R3561 T5091 T5090 arg2Of MyD88,(
R3562 T5092 T5090 arg3Of ),(
R3563 T5093 T5083 arg2Of and,recruit
R3564 T5093 T5086 arg1Of and,primary
R3565 T5097 T5093 arg2Of IFNβ,and
R3566 T5097 T5094 arg1Of IFNβ,TIR
R3567 T5097 T5095 arg1Of IFNβ,domain-containing
R3568 T5097 T5096 arg1Of IFNβ,adaptor-inducing
R3569 T5097 T5098 arg1Of IFNβ,(
R3570 T5099 T5098 arg2Of TRIF,(
R3571 T5100 T5098 arg3Of ),(
R3572 T5103 T5106 arg1Of MyD88,recruits
R3573 T5105 T5104 arg2Of turn,in
R3574 T5106 T5104 arg1Of recruits,in
R3575 T5106 T5118 arg1Of recruits,","
R3576 T5106 T5119 modOf recruits,leading
R3577 T5106 T5126 arg1Of recruits,[
R3578 T5107 T5106 arg2Of members,recruits
R3579 T5107 T5108 arg1Of members,of
R3580 T5113 T5112 arg2Of IRAK,(
R3581 T5114 T5112 arg3Of ),(
R3582 T5115 T5116 arg1Of family,and
R3583 T5116 T5108 arg2Of and,of
R3584 T5116 T5109 arg1Of and,the
R3585 T5116 T5110 arg1Of and,IL-1R-associated
R3586 T5116 T5111 arg1Of and,kinase
R3587 T5116 T5112 arg1Of and,(
R3588 T5117 T5116 arg2Of TRAF6,and
R3589 T5119 T5120 arg1Of leading,to
R3590 T5121 T5122 arg1Of oligomerisation,and
R3591 T5122 T5120 arg2Of and,to
R3592 T5122 T5124 arg1Of and,of
R3593 T5123 T5122 arg2Of selfubiquitination,and
R3594 T5125 T5124 arg2Of TRAF6,of
R3595 T5127 T5126 arg2Of 24,[
R3596 T5128 T5126 arg3Of ],[
R3597 T5129 T5131 arg1Of TRIF,recruits
R3598 T5131 T5130 arg1Of recruits,also
R3599 T5131 T5141 arg1Of recruits,via
R3600 T5132 T5133 arg1Of TRAF6,[
R3601 T5132 T5136 arg1Of TRAF6,and
R3602 T5134 T5133 arg2Of 25,[
R3603 T5135 T5133 arg3Of ],[
R3604 T5136 T5131 arg2Of and,recruits
R3605 T5137 T5136 arg2Of RIP1,and
R3606 T5137 T5138 arg1Of RIP1,[
R3607 T5139 T5138 arg2Of 26,[
R3608 T5140 T5138 arg3Of ],[
R3609 T5144 T5141 arg2Of interaction,via
R3610 T5144 T5142 arg1Of interaction,a
R3611 T5144 T5143 arg1Of interaction,direct
R3612 T5146 T5145 arg1Of pathways,Both
R3613 T5146 T5148 arg1Of pathways,activate
R3614 T5148 T5147 arg1Of activate,then
R3615 T5148 T5152 arg1Of activate,in
R3616 T5149 T5150 arg1Of TAK1,and
R3617 T5150 T5148 arg2Of and,activate
R3618 T5151 T5150 arg2Of IKK,and
R3619 T5155 T5152 arg2Of manner,in
R3620 T5155 T5153 arg1Of manner,a
R3621 T5155 T5154 arg1Of manner,ubiquitination-dependent
R3622 T5155 T5156 arg1Of manner,similar
R3623 T5156 T5157 arg1Of similar,to
R3624 T5160 T5157 arg2Of pathway,to
R3625 T5160 T5158 arg1Of pathway,the
R3626 T5160 T5159 arg1Of pathway,TNF
R3627 T5160 T5161 arg1Of pathway,(
R3628 T5162 T5161 arg2Of Figure,(
R3629 T5162 T5163 arg1Of Figure,1
R3630 T5164 T5161 arg3Of ),(
R3631 T5168 T5165 arg1Of pathway,The
R3632 T5168 T5166 arg1Of pathway,noncanonical
R3633 T5168 T5167 arg1Of pathway,NF-κB
R3634 T5168 T5169 arg1Of pathway,can
R3635 T5168 T5170 arg1Of pathway,be
R3636 T5168 T5171 arg2Of pathway,activated
R3637 T5171 T5169 arg2Of activated,can
R3638 T5171 T5170 arg2Of activated,be
R3639 T5171 T5172 arg1Of activated,by
R3640 T5176 T5173 arg1Of receptor,the
R3641 T5176 T5174 arg1Of receptor,lymphotoxin
R3642 T5176 T5175 arg1Of receptor,β
R3643 T5176 T5177 arg1Of receptor,","
R3644 T5176 T5180 arg1Of receptor,","
R3645 T5179 T5177 arg2Of receptor,","
R3646 T5179 T5178 arg1Of receptor,BAFF
R3647 T5180 T5183 arg1Of ",",and
R3648 T5181 T5180 arg2Of CD40,","
R3649 T5183 T5172 arg2Of and,by
R3650 T5183 T5182 arg1Of and,","
R3651 T5184 T5183 arg2Of RANK,and
R3652 T5184 T5185 arg1Of RANK,(
R3653 T5186 T5185 arg2Of Figure,(
R3654 T5186 T5187 arg1Of Figure,2
R3655 T5188 T5185 arg3Of ),(
R3656 T5191 T5189 arg2Of pathway,In
R3657 T5191 T5190 arg1Of pathway,this
R3658 T5193 T5194 arg1Of p100,is
R3659 T5193 T5195 arg2Of p100,processed
R3660 T5195 T5194 arg2Of processed,is
R3661 T5195 T5226 arg1Of processed,and
R3662 T5198 T5199 arg1Of proteasome,to
R3663 T5198 T5201 arg1Of proteasome,","
R3664 T5198 T5202 arg1Of proteasome,which
R3665 T5198 T5209 arg1Of proteasome,regulates
R3666 T5198 T5220 arg1Of proteasome,","
R3667 T5200 T5199 arg2Of p52,to
R3668 T5203 T5204 arg1Of together,with
R3669 T5208 T5204 arg2Of subunit,with
R3670 T5208 T5205 arg1Of subunit,the
R3671 T5208 T5206 arg1Of subunit,RelB
R3672 T5208 T5207 arg1Of subunit,NF-κB
R3673 T5209 T5203 arg1Of regulates,together
R3674 T5212 T5209 arg2Of set,regulates
R3675 T5212 T5210 arg1Of set,a
R3676 T5212 T5211 arg1Of set,distinct
R3677 T5212 T5213 arg1Of set,of
R3678 T5215 T5213 arg2Of genes,of
R3679 T5215 T5214 arg1Of genes,target
R3680 T5215 T5216 arg1Of genes,that
R3681 T5215 T5217 arg1Of genes,control
R3682 T5219 T5217 arg2Of development,control
R3683 T5219 T5218 arg1Of development,B-cell
R3684 T5220 T5195 arg1Of ",",processed
R3685 T5220 T5196 arg2Of ",",by
R3686 T5220 T5197 arg1Of ",",the
R3687 T5224 T5220 arg2Of development,","
R3688 T5224 T5221 arg1Of development,secondary
R3689 T5224 T5222 arg1Of development,lymphoid
R3690 T5224 T5223 arg1Of development,organ
R3691 T5226 T5189 arg1Of and,In
R3692 T5226 T5192 arg1Of and,","
R3693 T5226 T5225 arg1Of and,","
R3694 T5229 T5228 arg2Of 27,[
R3695 T5230 T5228 arg3Of ],[
R3696 T5232 T5231 arg1Of noncanonical,The
R3697 T5234 T5227 arg1Of pathway,osteoclastogenesis
R3698 T5234 T5228 arg1Of pathway,[
R3699 T5234 T5232 arg1Of pathway,noncanonical
R3700 T5234 T5233 arg1Of pathway,NF-κB
R3701 T5234 T5235 arg1Of pathway,is
R3702 T5234 T5237 arg1Of pathway,dependent
R3703 T5235 T5226 arg2Of is,and
R3704 T5237 T5235 arg2Of dependent,is
R3705 T5237 T5236 arg1Of dependent,strictly
R3706 T5237 T5238 arg1Of dependent,on
R3707 T5239 T5238 arg2Of IKK1,on
R3708 T5239 T5240 arg1Of IKK1,","
R3709 T5239 T5241 arg1Of IKK1,which
R3710 T5239 T5242 arg1Of IKK1,is
R3711 T5239 T5243 arg2Of IKK1,activated
R3712 T5243 T5242 arg2Of activated,is
R3713 T5243 T5244 arg1Of activated,upon
R3714 T5245 T5244 arg2Of phosphorylation,upon
R3715 T5245 T5246 arg1Of phosphorylation,by
R3716 T5247 T5246 arg2Of NF-κB,by
R3717 T5247 T5248 arg1Of NF-κB,inducing
R3718 T5249 T5248 arg2Of kinase,inducing
R3719 T5249 T5250 arg1Of kinase,(
R3720 T5251 T5250 arg2Of NIK,(
R3721 T5252 T5250 arg3Of ),(
R3722 T5253 T5254 arg1Of NIK,is
R3723 T5253 T5256 arg2Of NIK,regulated
R3724 T5253 T5262 arg1Of NIK,is
R3725 T5253 T5263 arg1Of NIK,present
R3726 T5256 T5254 arg2Of regulated,is
R3727 T5256 T5255 arg1Of regulated,predominantly
R3728 T5256 T5257 arg1Of regulated,at
R3729 T5256 T5261 arg1Of regulated,and
R3730 T5260 T5257 arg2Of level,at
R3731 T5260 T5258 arg1Of level,the
R3732 T5260 T5259 arg1Of level,post-translational
R3733 T5262 T5261 arg2Of is,and
R3734 T5263 T5262 arg2Of present,is
R3735 T5263 T5264 arg1Of present,at
R3736 T5263 T5268 arg1Of present,in
R3737 T5266 T5265 arg1Of low,extremely
R3738 T5267 T5264 arg2Of levels,at
R3739 T5267 T5266 arg1Of levels,low
R3740 T5271 T5268 arg2Of types,in
R3741 T5271 T5269 arg1Of types,most
R3742 T5271 T5270 arg1Of types,cell
R3743 T5274 T5272 arg2Of cells,In
R3744 T5274 T5273 arg1Of cells,unstimulated
R3745 T5276 T5277 arg1Of NIK,occurs
R3746 T5277 T5272 arg1Of occurs,In
R3747 T5277 T5275 arg1Of occurs,","
R3748 T5277 T5278 arg1Of occurs,in
R3749 T5277 T5293 arg1Of occurs,","
R3750 T5277 T5294 modOf occurs,leading
R3751 T5281 T5278 arg2Of complex,in
R3752 T5281 T5279 arg1Of complex,a
R3753 T5281 T5280 arg1Of complex,cytoplasmic
R3754 T5281 T5282 arg1Of complex,with
R3755 T5283 T5284 arg1Of TRAF2,","
R3756 T5284 T5287 arg1Of ",",and
R3757 T5285 T5284 arg2Of TRAF3,","
R3758 T5287 T5282 arg2Of and,with
R3759 T5287 T5286 arg1Of and,","
R3760 T5287 T5289 arg1Of and,","
R3761 T5287 T5290 arg1Of and,which
R3762 T5287 T5291 arg1Of and,K48-polyubiquitinates
R3763 T5288 T5287 arg2Of cIAP1/2,and
R3764 T5292 T5291 arg2Of NIK,K48-polyubiquitinates
R3765 T5294 T5295 arg1Of leading,to
R3766 T5298 T5295 arg2Of degradation,to
R3767 T5298 T5296 arg1Of degradation,its
R3768 T5298 T5297 arg1Of degradation,continuous
R3769 T5298 T5299 arg1Of degradation,by
R3770 T5301 T5299 arg2Of proteasome,by
R3771 T5301 T5300 arg1Of proteasome,the
R3772 T5303 T5302 arg1Of ligation,Receptor
R3773 T5303 T5304 arg1Of ligation,has
R3774 T5303 T5305 arg1Of ligation,been
R3775 T5303 T5306 arg2Of ligation,shown
R3776 T5306 T5304 arg2Of shown,has
R3777 T5306 T5305 arg2Of shown,been
R3778 T5306 T5309 modOf shown,to
R3779 T5306 T5324 modOf shown,to
R3780 T5308 T5307 arg1Of only,not
R3781 T5310 T5309 arg1Of remove,to
R3782 T5310 T5315 arg1Of remove,by
R3783 T5310 T5322 arg1Of remove,but
R3784 T5311 T5310 arg2Of TRAF3,remove
R3785 T5311 T5312 arg1Of TRAF3,from
R3786 T5314 T5312 arg2Of complex,from
R3787 T5314 T5313 arg1Of complex,this
R3788 T5316 T5315 arg2Of recruiting,by
R3789 T5316 T5318 arg1Of recruiting,to
R3790 T5317 T5316 arg2Of it,recruiting
R3791 T5320 T5318 arg2Of receptor,to
R3792 T5320 T5319 arg1Of receptor,the
R3793 T5322 T5308 arg1Of but,only
R3794 T5322 T5321 arg1Of but,","
R3795 T5322 T5323 arg1Of but,also
R3796 T5325 T5322 arg2Of attract,but
R3797 T5325 T5324 arg1Of attract,to
R3798 T5326 T5327 arg1Of TRAF2,and
R3799 T5327 T5325 arg2Of and,attract
R3800 T5327 T5329 arg1Of and,","
R3801 T5327 T5330 arg1Of and,which
R3802 T5327 T5331 arg1Of and,are
R3803 T5327 T5332 arg1Of and,essential
R3804 T5328 T5327 arg2Of cIAP1/2,and
R3805 T5332 T5331 arg2Of essential,are
R3806 T5332 T5333 arg1Of essential,for
R3807 T5336 T5333 arg2Of degradation,for
R3808 T5336 T5334 arg1Of degradation,subsequent
R3809 T5336 T5335 arg1Of degradation,TRAF3
R3810 T5338 T5337 arg1Of this,All
R3811 T5338 T5339 arg1Of this,contributes
R3812 T5339 T5340 arg1Of contributes,to
R3813 T5341 T5340 arg2Of releasing,to
R3814 T5341 T5343 arg1Of releasing,from
R3815 T5341 T5347 arg1Of releasing,","
R3816 T5341 T5348 modOf releasing,resulting
R3817 T5341 T5355 arg1Of releasing,[
R3818 T5341 T5358 arg1Of releasing,(
R3819 T5342 T5341 arg2Of NIK,releasing
R3820 T5346 T5343 arg2Of degradation,from
R3821 T5346 T5344 arg1Of degradation,its
R3822 T5346 T5345 arg1Of degradation,constitutive
R3823 T5348 T5349 arg1Of resulting,in
R3824 T5351 T5350 arg1Of accumulation,NIK
R3825 T5351 T5352 arg1Of accumulation,and
R3826 T5352 T5349 arg2Of and,in
R3827 T5389 T5387 arg2Of ligand,of
R3828 T5389 T5388 arg1Of ligand,their
R3829 T5354 T5352 arg2Of phosphorylation,and
R3830 T5391 T5392 arg1Of CD40,and
R3831 T5354 T5353 arg1Of phosphorylation,IKK1
R3832 T5392 T5394 arg1Of and,interact
R3833 T5393 T5392 arg2Of RANK,and
R3834 T5356 T5355 arg2Of "28,29",[
R3835 T5394 T5395 arg1Of interact,with
R3836 T5357 T5355 arg3Of ],[
R3837 T5394 T5412 arg1Of interact,and
R3838 T5359 T5358 arg2Of Figure,(
R3839 T5398 T5395 arg2Of members,with
R3840 T5398 T5396 arg1Of members,several
R3841 T5398 T5397 arg1Of members,TRAF
R3842 T5398 T5399 arg1Of members,","
R3843 T5398 T5400 arg1Of members,including
R3844 T5401 T5402 arg1Of TRAF1,","
R3845 T5402 T5404 arg1Of ",",","
R3846 T5403 T5402 arg2Of TRAF2,","
R3847 T5359 T5360 arg1Of Figure,2
R3848 T5404 T5406 arg1Of ",",","
R3849 T5361 T5358 arg3Of ),(
R3850 T5405 T5404 arg2Of TRAF3,","
R3851 T5406 T5409 arg1Of ",",and
R3852 T5407 T5406 arg2Of TRAF5,","
R3853 T5362 T5363 arg1Of It,should
R3854 T5409 T5400 arg2Of and,including
R3855 T5409 T5408 arg1Of and,","
R3856 T5410 T5409 arg2Of TRAF6,and
R3857 T5362 T5364 arg1Of It,be
R3858 T5412 T5385 arg1Of and,Upon
R3859 T5412 T5390 arg1Of and,","
R3860 T5412 T5411 arg1Of and,","
R3861 T5364 T5363 arg2Of be,should
R3862 T5413 T5414 arg1Of this,leads
R3863 T5414 T5412 arg2Of leads,and
R3864 T5414 T5415 arg1Of leads,to
R3865 T5367 T5364 arg2Of CD40,be
R3866 T5417 T5415 arg2Of proteolysis,to
R3867 T5417 T5416 arg1Of proteolysis,the
R3868 T5417 T5418 arg1Of proteolysis,of
R3869 T5417 T5423 arg1Of proteolysis,","
R3870 T5417 T5424 arg1Of proteolysis,which
R3871 T5417 T5425 arg1Of proteolysis,represents
R3872 T5420 T5421 arg1Of TRAF2,and
R3873 T5421 T5418 arg2Of and,of
R3874 T5421 T5419 arg1Of and,both
R3875 T5422 T5421 arg2Of TRAF3,and
R3876 T5367 T5365 arg2Of CD40,mentioned
R3877 T5425 T5436 arg1Of represents,as
R3878 T5367 T5366 arg1Of CD40,that
R3879 T5371 T5372 arg1Of receptor,and
R3880 T5428 T5425 arg2Of step,represents
R3881 T5428 T5426 arg1Of step,an
R3882 T5428 T5427 arg1Of step,important
R3883 T5428 T5429 arg1Of step,in
R3884 T5372 T5369 arg1Of and,lymphotoxin
R3885 T5372 T5370 arg1Of and,β
R3891 T5435 T5433 arg1Of pathway,the
R3892 T5435 T5434 arg1Of pathway,noncanonical
R3893 T5373 T5372 arg2Of RANK,and
R3894 T5437 T5436 arg2Of described,as
R3895 T5437 T5438 arg1Of described,above
R3896 T5374 T5363 modOf mediate,should
R3897 T5441 T5439 arg1Of molecules,Specific
R3898 T5441 T5440 arg1Of molecules,TRAF
R3899 T5441 T5442 arg1Of molecules,are
R3900 T5441 T5443 arg2Of molecules,associated
R3901 T5443 T5442 arg2Of associated,are
R3902 T5443 T5444 arg1Of associated,with
R3903 T5374 T5368 arg1Of mediate,","
R3904 T5376 T5374 arg2Of activation,mediate
R3905 T5376 T5375 arg1Of activation,the
R3906 T5449 T5444 arg2Of functions,with
R3907 T5449 T5445 arg1Of functions,overlapping
R3908 T5449 T5446 arg1Of functions,and
R3909 T5449 T5447 arg1Of functions,distinct
R3910 T5449 T5448 arg1Of functions,CD40-mediated
R3911 T5376 T5377 arg1Of activation,of
R3912 T5451 T5450 arg2Of example,For
R3913 T5379 T5380 arg1Of canonical,and
R3914 T5455 T5453 arg2Of cells,in
R3915 T5455 T5454 arg1Of cells,B
R3916 T5456 T5457 arg1Of TRAF6,is
R3917 T5456 T5458 arg2Of TRAF6,required
R3918 T5380 T5378 arg1Of and,both
R3919 T5458 T5457 arg2Of required,is
R3920 T5458 T5459 arg1Of required,for
R3921 T5458 T5466 arg1Of required,","
R3922 T5458 T5467 arg1Of required,while
R3923 T5458 T5476 arg1Of required,and
R3924 T5381 T5380 arg2Of noncanonical,and
R3925 T5462 T5460 arg1Of activation,CD40-mediated
R3926 T5462 T5461 arg1Of activation,JNK
R3927 T5462 T5463 arg1Of activation,and
R3928 T5463 T5459 arg2Of and,for
R3929 T5384 T5377 arg2Of pathways,of
R3930 T5465 T5463 arg2Of production,and
R3931 T5465 T5464 arg1Of production,IL-6
R3932 T5468 T5469 arg1Of TRAF2,is
R3933 T5468 T5470 arg2Of TRAF2,required
R3934 T5470 T5467 arg2Of required,while
R3935 T5470 T5469 arg2Of required,is
R3936 T5470 T5471 arg1Of required,for
R3937 T5384 T5379 arg1Of pathways,canonical
R3938 T5472 T5471 arg2Of activation,for
R3939 T5472 T5473 arg1Of activation,of
R3940 T5474 T5473 arg2Of NF-κB,of
R3941 T5476 T5450 arg1Of and,For
R3942 T5476 T5452 arg1Of and,","
R3943 T5476 T5453 arg1Of and,in
R3944 T5476 T5475 arg1Of and,","
R3945 T5477 T5478 arg1Of TRAF3,serves
R3946 T5384 T5381 arg1Of pathways,noncanonical
R3947 T5478 T5476 arg2Of serves,and
R3948 T5478 T5479 arg1Of serves,as
R3949 T5384 T5382 arg1Of pathways,NF-κB
R3950 T5384 T5383 arg1Of pathways,signalling
R3951 T5386 T5385 arg2Of binding,Upon
R3952 T5478 T5486 arg1Of serves,[
R3953 T5386 T5387 arg1Of binding,of
R3954 T5485 T5483 arg2Of signalling,of
R3955 T5482 T5479 arg2Of regulator,as
R3956 T5482 T5480 arg1Of regulator,a
R3957 T5482 T5481 arg1Of regulator,negative
R3958 T5482 T5483 arg1Of regulator,of
R3959 T5485 T5484 arg1Of signalling,CD40
R3960 T5487 T5486 arg2Of "30,31",[
R3961 T5488 T5486 arg3Of ],[
R5593 T8428 T8427 arg1Of activation,NF-κB
R5594 T8428 T8429 arg1Of activation,is
R5595 T8428 T8431 arg1Of activation,crucial
R5596 T8429 T8426 arg2Of is,Since
R5597 T8431 T8429 arg2Of crucial,is
R5598 T8431 T8430 arg1Of crucial,so
R5599 T8431 T8432 arg1Of crucial,to
R5600 T8435 T8432 arg2Of processes,to
R5601 T8435 T8433 arg1Of processes,many
R5602 T8435 T8434 arg1Of processes,cellular
R5603 T8439 T8437 arg1Of regulation,a
R5604 T8439 T8438 arg1Of regulation,tight
R5605 T8439 T8440 arg1Of regulation,of
R5606 T8439 T8445 arg1Of regulation,and
R5607 T8444 T8440 arg2Of pathway,of
R5608 T8444 T8441 arg1Of pathway,the
R5609 T8444 T8442 arg1Of pathway,NF-κB
R5610 T8444 T8443 arg1Of pathway,signalling
R5611 T8445 T8450 arg1Of and,is
R5612 T8447 T8445 arg2Of genes,and
R5613 T8447 T8446 arg1Of genes,the
R5614 T8447 T8449 arg2Of genes,induces
R5615 T8448 T8449 arg1Of it,induces
R5616 T8450 T8426 arg1Of is,Since
R5617 T8450 T8436 arg1Of is,","
R5618 T8453 T8450 arg2Of requirement,is
R5619 T8453 T8451 arg1Of requirement,an
R5620 T8453 T8452 arg1Of requirement,absolute
R5621 T8453 T8454 modOf requirement,to
R5622 T8453 T8455 arg1Of requirement,fine-tune
R5623 T8455 T8454 arg1Of fine-tune,to
R5624 T8458 T8455 arg2Of response,fine-tune
R5625 T8458 T8456 arg1Of response,the
R5626 T8458 T8457 arg1Of response,inflammatory
R5627 T8461 T8465 arg1Of terminating,is
R5628 T8461 T8466 arg1Of terminating,essential
R5629 T8464 T8461 arg2Of response,terminating
R5630 T8464 T8462 arg1Of response,an
R5631 T8464 T8463 arg1Of response,NF-κB
R5632 T8465 T8459 arg1Of is,Moreover
R5633 T8465 T8460 arg1Of is,","
R5634 T8466 T8465 arg2Of essential,is
R5635 T8468 T8466 arg2Of prevent,essential
R5636 T8468 T8467 arg1Of prevent,to
R5637 T8471 T8468 arg2Of activation,prevent
R5638 T8471 T8469 arg1Of activation,persistent
R5639 T8471 T8470 arg1Of activation,NF-κB
R5640 T8471 T8472 arg1Of activation,that
R5641 T8471 T8473 arg1Of activation,may
R5642 T8471 T8474 arg1Of activation,lead
R5643 T8474 T8473 arg2Of lead,may
R5644 T8474 T8475 arg1Of lead,to
R5645 T8477 T8478 arg1Of inflammation,and/or
R5646 T8478 T8475 arg2Of and/or,to
R5647 T8478 T8476 arg1Of and/or,chronic
R5648 T8479 T8478 arg2Of tumorigenesis,and/or
R5649 T8481 T8480 arg1Of achieve,To
R5650 T8482 T8481 arg2Of this,achieve
R5651 T8484 T8481 arg1Of cells,achieve
R5652 T8484 T8485 arg1Of cells,employ
R5653 T8485 T8480 modOf employ,To
R5654 T8485 T8483 arg1Of employ,","
R5655 T8487 T8485 arg2Of mechanisms,employ
R5656 T8487 T8486 arg1Of mechanisms,different
R5657 T8487 T8488 arg1Of mechanisms,","
R5658 T8487 T8489 arg1Of mechanisms,including
R5659 T8491 T8489 arg2Of expression,including
R5660 T8491 T8490 arg1Of expression,the
R5661 T8491 T8492 arg1Of expression,of
R5662 T8494 T8492 arg2Of proteins,of
R5663 T8494 T8493 arg1Of proteins,inhibitory
R5664 T8494 T8495 arg1Of proteins,that
R5665 T8494 T8496 arg1Of proteins,downregulate
R5666 T8496 T8499 arg1Of downregulate,[
R5667 T8498 T8496 arg2Of signalling,downregulate
R5668 T8498 T8497 arg1Of signalling,NF-κB
R5669 T8500 T8499 arg2Of 32,[
R5670 T8501 T8499 arg3Of ],[
R5671 T8503 T8504 arg1Of we,give
R5672 T8504 T8524 arg1Of give,","
R5673 T8506 T8504 arg2Of overview,give
R5674 T8506 T8505 arg1Of overview,an
R5675 T8506 T8507 arg1Of overview,of
R5676 T8509 T8507 arg2Of number,of
R5677 T8509 T8508 arg1Of number,a
R5678 T8509 T8510 arg1Of number,of
R5679 T8511 T8510 arg2Of proteins,of
R5680 T8511 T8512 arg1Of proteins,that
R5681 T8511 T8513 arg1Of proteins,are
R5682 T8511 T8514 arg2Of proteins,involved
R5683 T8514 T8513 arg2Of involved,are
R5684 T8514 T8515 arg1Of involved,in
R5685 T8517 T8518 arg1Of dampening,or
R5686 T8518 T8515 arg2Of or,in
R5687 T8518 T8516 arg1Of or,the
R5688 T8518 T8520 arg1Of or,of
R5689 T8519 T8518 arg2Of termination,or
R5690 T8523 T8520 arg2Of response,of
R5691 T8523 T8521 arg1Of response,the
R5692 T8523 T8522 arg1Of response,NF-κB
R5693 T8525 T8504 arg3Of some,give
R5694 T8525 T8526 arg1Of some,of
R5695 T8527 T8526 arg2Of them,of
R5696 T8530 T8528 arg2Of control,under
R5697 T8530 T8529 arg1Of control,the
R5698 T8530 T8531 arg1Of control,of
R5699 T8533 T8531 arg2Of itself,of
R5700 T8533 T8532 arg1Of itself,NF-κB
R5701 T8536 T8534 arg2Of acting,and
R5702 T8536 T8535 arg1Of acting,thus
R5703 T8536 T8537 arg1Of acting,in
R5704 T8541 T8537 arg2Of loop,in
R5705 T8541 T8538 arg1Of loop,a
R5706 T8541 T8539 arg1Of loop,negative
R5707 T8541 T8540 arg1Of loop,feedback
R5708 T8543 T8542 arg2Of addition,In
R5709 T8545 T8546 arg1Of we,discuss
R5710 T8546 T8542 arg1Of discuss,In
R5711 T8546 T8544 arg1Of discuss,","
R5712 T8549 T8546 arg2Of role,discuss
R5713 T8549 T8547 arg1Of role,the
R5714 T8549 T8548 arg1Of role,potential
R5715 T8549 T8550 arg1Of role,of
R5716 T8549 T8555 arg1Of role,in
R5717 T8554 T8550 arg2Of factors,of
R5718 T8554 T8551 arg1Of factors,these
R5719 T8554 T8552 arg1Of factors,NF-κB
R5720 T8554 T8553 arg1Of factors,inhibitory
R5721 T8557 T8555 arg2Of immunopathology,in
R5722 T8557 T8556 arg1Of immunopathology,the
R5723 T8557 T8558 arg1Of immunopathology,of
R5724 T8559 T8558 arg2Of RA,of
R5725 T8562 T8560 arg1Of proteins,Several
R5726 T8562 T8561 arg1Of proteins,other
R5727 T8562 T8563 arg2Of proteins,involved
R5728 T8562 T8572 arg1Of proteins,","
R5729 T8562 T8574 arg1Of proteins,as
R5730 T8562 T8582 arg1Of proteins,have
R5731 T8562 T8583 arg1Of proteins,been
R5732 T8562 T8584 arg2Of proteins,described
R5733 T8563 T8564 arg1Of involved,in
R5734 T8567 T8564 arg2Of regulation,in
R5735 T8567 T8565 arg1Of regulation,the
R5736 T8567 T8566 arg1Of regulation,negative
R5737 T8567 T8568 arg1Of regulation,of
R5738 T8571 T8568 arg2Of responses,of
R5739 T8571 T8569 arg1Of responses,NF-κB-dependent
R5740 T8571 T8570 arg1Of responses,inflammatory
R5741 T8574 T8573 arg1Of as,such
R5742 T8575 T8576 arg1Of MyD88s,","
R5743 T8576 T8579 arg1Of ",",and
R5744 T8577 T8576 arg2Of IRAK-M,","
R5745 T8579 T8574 arg2Of and,as
R5746 T8579 T8578 arg1Of and,","
R5747 T8580 T8579 arg2Of TOLLIP,and
R5748 T8584 T8581 arg1Of described,","
R5749 T8584 T8582 arg2Of described,have
R5750 T8584 T8583 arg2Of described,been
R5751 T8584 T8585 arg1Of described,(
R5752 T8586 T8585 arg2Of reviewed,(
R5753 T8586 T8587 arg1Of reviewed,in
R5754 T8586 T8588 arg1Of reviewed,[
R5755 T8589 T8588 arg2Of 33,[
R5756 T8590 T8588 arg3Of ],[
R5757 T8591 T8585 arg3Of ),(
R5758 T8593 T8592 arg1Of proteins,These
R5759 T8593 T8594 arg1Of proteins,are
R5760 T8593 T8596 arg2Of proteins,discussed
R5761 T8596 T8594 arg2Of discussed,are
R5762 T8596 T8595 arg1Of discussed,not
R5763 T8596 T8597 arg1Of discussed,here
R5764 T8596 T8598 arg1Of discussed,","
R5765 T8596 T8599 arg1Of discussed,since
R5766 T8601 T8600 arg1Of link,a
R5767 T8601 T8602 arg1Of link,with
R5768 T8601 T8605 arg1Of link,has
R5769 T8601 T8608 arg1Of link,been
R5770 T8604 T8602 arg2Of pathology,with
R5771 T8604 T8603 arg1Of pathology,RA
R5772 T8608 T8605 arg2Of been,has
R5773 T8608 T8606 arg1Of been,not
R5774 T8608 T8607 arg1Of been,yet
R5775 T8608 T8609 arg1Of been,"reported. Although"
R5776 T8608 T8620 arg1Of been,","
R5777 T8610 T8611 arg1Of IKK1,is
R5778 T8611 T8609 arg2Of is,"reported. Although"
R5779 T8614 T8611 arg2Of component,is
R5780 T8614 T8612 arg1Of component,a
R5781 T8614 T8613 arg1Of component,critical
R5782 T8614 T8615 arg1Of component,of
R5783 T8619 T8615 arg2Of pathway,of
R5784 T8619 T8616 arg1Of pathway,the
R5785 T8619 T8617 arg1Of pathway,non-canonical
R5786 T8619 T8618 arg1Of pathway,NF-κB
R5787 T8620 T8599 arg2Of ",",since
R5788 T8621 T8622 arg1Of it,should
R5789 T8621 T8623 arg1Of it,be
R5790 T8621 T8624 arg2Of it,mentioned
R5791 T8624 T8622 arg2Of mentioned,should
R5792 T8624 T8623 arg2Of mentioned,be
R5793 T8624 T8625 arg1Of mentioned,that
R5794 T8627 T8626 arg1Of kinase,this
R5795 T8627 T8629 arg1Of kinase,plays
R5796 T8629 T8620 arg2Of plays,","
R5797 T8629 T8622 modOf plays,should
R5798 T8629 T8628 arg1Of plays,also
R5799 T8629 T8633 arg1Of plays,in
R5800 T8632 T8629 arg2Of role,plays
R5801 T8632 T8630 arg1Of role,a
R5802 T8632 T8631 arg1Of role,prominent
R5803 T8636 T8633 arg2Of regulation,in
R5804 T8636 T8634 arg1Of regulation,the
R5805 T8636 T8635 arg1Of regulation,negative
R5806 T8636 T8637 arg1Of regulation,of
R5807 T8639 T8640 arg1Of canonical,and
R5808 T8640 T8638 arg1Of and,both
R5809 T8641 T8640 arg2Of noncanonical,and
R5810 T8643 T8637 arg2Of pathways,of
R5811 T8643 T8639 arg1Of pathways,canonical
R5812 T8643 T8641 arg1Of pathways,noncanonical
R5813 T8643 T8642 arg1Of pathways,NF-κB
R5814 T8644 T8645 arg1Of Macrophages,from
R5815 T8644 T8654 arg1Of Macrophages,show
R5816 T8647 T8646 arg1Of mice,IKK1-deficient
R5817 T8647 T8648 arg1Of mice,or
R5818 T8648 T8645 arg2Of or,from
R5819 T8650 T8648 arg2Of mice,or
R5820 T8650 T8649 arg1Of mice,knockin
R5821 T8650 T8651 arg1Of mice,expressing
R5822 T8653 T8651 arg2Of IKK1,expressing
R5823 T8653 T8652 arg1Of IKK1,inactive
R5824 T8654 T8660 arg1Of show,as
R5825 T8654 T8670 arg1Of show,[
R5826 T8656 T8654 arg2Of production,show
R5827 T8656 T8655 arg2Of production,increased
R5828 T8656 T8657 arg1Of production,of
R5829 T8659 T8657 arg2Of cytokines,of
R5830 T8659 T8658 arg1Of cytokines,proinflammatory
R5831 T8662 T8660 arg2Of result,as
R5832 T8662 T8661 arg1Of result,a
R5833 T8662 T8663 arg1Of result,of
R5834 T8666 T8664 arg2Of activation,enhanced
R5835 T8666 T8665 arg1Of activation,IKK2
R5836 T8666 T8667 arg1Of activation,and
R5837 T8667 T8663 arg2Of and,of
R5838 T8669 T8667 arg2Of degradation,and
R5842 T8673 T8674 arg1Of IKK1,has
R5843 T8673 T8676 arg1Of IKK1,been
R5844 T8673 T8677 arg2Of IKK1,shown
R5845 T8673 T8679 arg1Of IKK1,inhibit
R5846 T8673 T8684 arg1Of IKK1,downregulate
R5847 T8673 T8688 arg1Of IKK1,phosphorylating
R5848 T8677 T8674 arg2Of shown,has
R5849 T8677 T8675 arg1Of shown,also
R5850 T8677 T8676 arg2Of shown,been
R5851 T8679 T8678 arg1Of inhibit,to
R5852 T8679 T8682 arg1Of inhibit,and
R5853 T8681 T8679 arg2Of NF-κB,inhibit
R5854 T8681 T8680 arg1Of NF-κB,nuclear
R5855 T8682 T8677 arg3Of and,shown
R5856 T8684 T8682 arg2Of downregulate,and
R5857 T8684 T8683 arg1Of downregulate,to
R5858 T8684 T8687 arg1Of downregulate,by
R5859 T8686 T8684 arg2Of signalling,downregulate
R5860 T8686 T8685 arg1Of signalling,proinflammatory
R5861 T8688 T8687 arg2Of phosphorylating,by
R5862 T8689 T8688 arg2Of STAT1,phosphorylating
R5863 T8689 T8690 arg1Of STAT1,[
R5864 T8691 T8690 arg2Of 35,[
R5865 T8692 T8690 arg3Of ],[
R5866 T8697 T8695 arg1Of study,a
R5867 T8697 T8696 arg1Of study,recent
R5868 T8697 T8698 arg1Of study,has
R5869 T8697 T8699 arg1Of study,demonstrated
R5870 T8699 T8693 arg1Of demonstrated,Interestingly
R5871 T8699 T8694 arg1Of demonstrated,","
R5872 T8699 T8698 arg2Of demonstrated,has
R5873 T8701 T8702 arg1Of IKK1,phosphorylates
R5874 T8702 T8699 arg2Of phosphorylates,demonstrated
R5875 T8702 T8700 arg1Of phosphorylates,that
R5876 T8702 T8704 arg1Of phosphorylates,in
R5877 T8702 T8716 arg1Of phosphorylates,","
R5878 T8702 T8717 modOf phosphorylates,supporting
R5879 T8703 T8702 arg2Of NIK,phosphorylates
R5880 T8707 T8704 arg2Of regulation,in
R5881 T8707 T8705 arg1Of regulation,negative
R5882 T8707 T8706 arg1Of regulation,feedback
R5883 T8707 T8708 arg1Of regulation,of
R5884 T8712 T8708 arg2Of pathway,of
R5885 T8712 T8709 arg1Of pathway,the
R5886 T8712 T8710 arg1Of pathway,noncanonical
R5887 T8712 T8711 arg1Of pathway,NF-κB
R5888 T8712 T8713 arg1Of pathway,[
R5889 T8714 T8713 arg2Of 36,[
R5890 T8715 T8713 arg3Of ],[
R5891 T8719 T8717 arg2Of idea,supporting
R5892 T8719 T8718 arg1Of idea,the
R5893 T8721 T8722 arg1Of IKK1,plays
R5894 T8721 T8726 arg1Of IKK1,terminating
R5895 T8722 T8719 arg2Of plays,idea
R5896 T8722 T8720 arg1Of plays,that
R5897 T8722 T8725 arg1Of plays,in
R5898 T8724 T8722 arg2Of roles,plays
R5899 T8724 T8723 arg1Of roles,important
R5900 T8726 T8725 arg2Of terminating,in
R5901 T8728 T8729 arg1Of canonical,and
R5902 T8729 T8727 arg1Of and,both
R5903 T8730 T8729 arg2Of noncanonical,and
R5904 T8732 T8726 arg2Of pathways,terminating
R5905 T8732 T8728 arg1Of pathways,canonical
R5906 T8732 T8730 arg1Of pathways,noncanonical
R5907 T8732 T8731 arg1Of pathways,NF-κB
R5908 T8732 T8733 arg1Of pathways,with
R5909 T8735 T8733 arg2Of implications,with
R5910 T8735 T8734 arg1Of implications,possible
R5911 T8735 T8736 arg1Of implications,for
R5912 T8739 T8736 arg2Of diseases,for
R5913 T8739 T8737 arg1Of diseases,chronic
R5914 T8739 T8738 arg1Of diseases,inflammatory
R5915 T8739 T8740 arg1Of diseases,like
R5916 T8741 T8740 arg2Of RA,like
R6414 T9822 T9821 arg1Of protein,A20
R6415 T9823 T9824 arg1Of A20,(
R6416 T9823 T9830 arg1Of A20,is
R6417 T9826 T9824 arg2Of known,(
R6418 T9826 T9825 arg1Of known,also
R6419 T9826 T9827 arg1Of known,as
R6420 T9828 T9827 arg2Of TNFAIP3,as
R6421 T9829 T9824 arg3Of ),(
R6422 T9833 T9830 arg2Of protein,is
R6423 T9833 T9831 arg1Of protein,a
R6424 T9833 T9832 arg1Of protein,ubiquitin-editing
R6425 T9833 T9834 arg1Of protein,that
R6426 T9833 T9836 arg1Of protein,regulates
R6427 T9836 T9835 arg1Of regulates,negatively
R6428 T9836 T9840 arg1Of regulates,in
R6429 T9839 T9836 arg2Of expression,regulates
R6430 T9839 T9837 arg1Of expression,NF-κB-dependent
R6431 T9839 T9838 arg1Of expression,gene
R6432 T9841 T9840 arg2Of response,in
R6433 T9841 T9842 arg1Of response,to
R6434 T9845 T9842 arg2Of stimuli,to
R6435 T9845 T9843 arg1Of stimuli,different
R6436 T9845 T9844 arg1Of stimuli,immune-activating
R6437 T9845 T9846 arg1Of stimuli,","
R6438 T9845 T9847 arg1Of stimuli,including
R6439 T9848 T9849 arg1Of TNF,","
R6440 T9849 T9851 arg1Of ",",and
R6441 T9850 T9849 arg2Of IL-1,","
R6442 T9851 T9854 arg1Of and,and
R6443 T9852 T9851 arg2Of antigens,and
R6444 T9854 T9847 arg2Of and,including
R6445 T9854 T9853 arg1Of and,","
R6446 T9856 T9854 arg2Of triggering,and
R6447 T9856 T9855 arg1Of triggering,the
R6448 T9856 T9857 arg1Of triggering,of
R6449 T9858 T9859 arg1Of TLRs,and
R6450 T9859 T9857 arg2Of and,of
R6451 T9862 T9860 arg1Of oligomerisation,the
R6452 T9862 T9861 arg1Of oligomerisation,nucleotide-binding
R6453 T9865 T9859 arg2Of receptor,and
R6454 T9865 T9862 arg1Of receptor,oligomerisation
R6455 T9865 T9863 arg1Of receptor,domain-containing
R6456 T9865 T9864 arg1Of receptor,2
R6457 T9865 T9866 arg1Of receptor,(
R6458 T9867 T9866 arg2Of reviewed,(
R6459 T9867 T9868 arg1Of reviewed,in
R6460 T9867 T9869 arg1Of reviewed,[
R6461 T9870 T9869 arg2Of 37,[
R6462 T9871 T9869 arg3Of ],[
R6463 T9872 T9866 arg3Of ),(
R6464 T9873 T9874 arg1Of A20,is
R6465 T9873 T9875 arg2Of A20,believed
R6466 T9873 T9877 arg1Of A20,inhibit
R6467 T9873 T9881 arg1Of A20,deubiquitinating
R6468 T9875 T9874 arg2Of believed,is
R6469 T9877 T9875 arg3Of inhibit,believed
R6470 T9877 T9876 arg1Of inhibit,to
R6471 T9877 T9880 arg1Of inhibit,by
R6472 T9879 T9877 arg2Of function,inhibit
R6473 T9879 T9878 arg1Of function,NF-κB
R6474 T9881 T9880 arg2Of deubiquitinating,by
R6475 T9885 T9881 arg2Of molecules,deubiquitinating
R6476 T9885 T9882 arg1Of molecules,specific
R6477 T9885 T9883 arg1Of molecules,NF-κB
R6478 T9885 T9884 arg1Of molecules,signalling
R6479 T9885 T9886 arg1Of molecules,","
R6480 T9885 T9888 arg1Of molecules,as
R6481 T9888 T9887 arg1Of as,such
R6482 T9889 T9890 arg1Of RIP1,","
R6483 T9890 T9892 arg1Of ",",","
R6484 T9891 T9890 arg2Of RIP2,","
R6485 T9892 T9894 arg1Of ",",and
R6486 T9893 T9892 arg2Of TRAF6,","
R6487 T9894 T9888 arg2Of and,as
R6488 T9894 T9896 arg1Of and,","
R6489 T9894 T9897 arg1Of and,which
R6490 T9894 T9898 arg1Of and,disrupts
R6491 T9895 T9894 arg2Of MALT1,and
R6492 T9898 T9902 arg1Of disrupts,[
R6493 T9898 T9905 arg1Of disrupts,(
R6494 T9901 T9898 arg2Of interactions,disrupts
R6495 T9901 T9899 arg1Of interactions,specific
R6496 T9901 T9900 arg1Of interactions,protein-protein
R6497 T9903 T9902 arg2Of 38-41,[
R6498 T9904 T9902 arg3Of ],[
R6499 T9906 T9905 arg2Of Figure,(
R6500 T9906 T9907 arg1Of Figure,1
R6501 T9908 T9905 arg3Of ),(
R6502 T9912 T9911 arg1Of disruption,the
R6503 T9912 T9913 arg1Of disruption,of
R6504 T9912 T9915 arg1Of disruption,between
R6505 T9912 T9925 arg1Of disruption,and
R6506 T9914 T9913 arg2Of interactions,of
R6507 T9919 T9915 arg2Of enzymes,between
R6508 T9919 T9916 arg1Of enzymes,E2
R6509 T9919 T9917 arg1Of enzymes,ubiquitin
R6510 T9919 T9918 arg1Of enzymes,conjugating
R6511 T9919 T9920 arg1Of enzymes,(
R6512 T9921 T9922 arg1Of Ubc13,and
R6513 T9922 T9920 arg2Of and,(
R6514 T9923 T9922 arg2Of Ubc5hc,and
R6515 T9924 T9920 arg3Of ),(
R6516 T9925 T9936 arg1Of and,were
R6517 T9925 T9937 arg2Of and,described
R6518 T9928 T9925 arg2Of ligases,and
R6519 T9928 T9926 arg1Of ligases,E3
R6520 T9928 T9927 arg1Of ligases,ubiquitin
R6521 T9928 T9929 arg1Of ligases,(
R6522 T9930 T9931 arg1Of TRAF6,","
R6523 T9931 T9933 arg1Of ",",and
R6524 T9932 T9931 arg2Of TRAF2,","
R6525 T9933 T9929 arg2Of and,(
R6526 T9934 T9933 arg2Of cIAP1/2,and
R6527 T9935 T9929 arg3Of ),(
R6528 T9937 T9909 arg1Of described,Recently
R6529 T9937 T9910 arg1Of described,","
R6530 T9937 T9936 arg2Of described,were
R6531 T9937 T9938 arg1Of described,as
R6532 T9941 T9938 arg2Of mechanism,as
R6533 T9941 T9939 arg1Of mechanism,another
R6534 T9941 T9940 arg1Of mechanism,important
R6535 T9941 T9942 arg2Of mechanism,used
R6536 T9942 T9943 arg1Of used,by
R6537 T9942 T9945 modOf used,to
R6538 T9944 T9943 arg2Of A20,by
R6539 T9946 T9945 arg1Of downregulate,to
R6540 T9946 T9949 arg1Of downregulate,[
R6541 T9948 T9946 arg2Of signalling,downregulate
R6542 T9948 T9947 arg1Of signalling,NF-κB
R6543 T9950 T9949 arg2Of 42,[
R6544 T9951 T9949 arg3Of ],[
R6545 T9953 T9952 arg1Of association,The
R6546 T9953 T9954 arg1Of association,of
R6547 T9953 T9956 arg1Of association,with
R6548 T9953 T9959 arg1Of association,requires
R6549 T9955 T9954 arg2Of A20,of
R6550 T9958 T9956 arg2Of targets,with
R6551 T9958 T9957 arg1Of targets,its
R6552 T9963 T9959 arg2Of proteins,requires
R6553 T9963 T9960 arg1Of proteins,specific
R6554 T9963 T9961 arg1Of proteins,ubiquitin-binding
R6555 T9963 T9962 arg1Of proteins,adaptor
R6556 T9963 T9964 arg1Of proteins,","
R6557 T9963 T9965 arg1Of proteins,including
R6558 T9967 T9965 arg2Of inhibitor,including
R6559 T9967 T9966 arg1Of inhibitor,A20-binding
R6560 T9967 T9968 arg1Of inhibitor,of
R6561 T9969 T9970 arg1Of NF-κB,(
R6562 T9969 T9973 arg1Of NF-κB,1
R6563 T9969 T9974 arg1Of NF-κB,and
R6564 T9971 T9970 arg2Of ABIN,(
R6565 T9972 T9970 arg3Of ),(
R6566 T9974 T9968 arg2Of and,of
R6567 T9976 T9974 arg2Of protein,and
R6568 T9976 T9975 arg1Of protein,Tax1-binding
R6569 T9976 T9977 arg1Of protein,1
R6570 T9976 T9978 arg1Of protein,[
R6571 T9979 T9978 arg2Of 43-46,[
R6572 T9980 T9978 arg3Of ],[
R6573 T9981 T9982 arg1Of Next,to
R6574 T9984 T9982 arg2Of role,to
R6575 T9984 T9983 arg1Of role,its
R6576 T9984 T9985 arg1Of role,in
R6577 T9986 T9985 arg2Of suppressing,in
R6578 T9988 T9986 arg2Of activation,suppressing
R6579 T9988 T9987 arg1Of activation,NF-κB
R6580 T9990 T9991 arg1Of A20,is
R6581 T9991 T9981 arg1Of is,Next
R6582 T9991 T9989 arg1Of is,","
R6583 T9991 T9992 arg1Of is,also
R6584 T9991 T9998 arg1Of is,","
R6585 T9991 T10001 arg1Of is,in
R6586 T9995 T9991 arg2Of inhibitor,is
R6587 T9995 T9993 arg1Of inhibitor,a
R6588 T9995 T9994 arg1Of inhibitor,strong
R6589 T9995 T9996 arg1Of inhibitor,of
R6590 T9997 T9996 arg2Of apoptosis,of
R6591 T10000 T9999 arg1Of least,at
R6592 T10001 T10000 arg1Of in,least
R6593 T10004 T10001 arg2Of types,in
R6594 T10004 T10002 arg1Of types,some
R6595 T10004 T10003 arg1Of types,cell
R6596 T10006 T10005 arg1Of mechanisms,The
R6597 T10006 T10007 arg2Of mechanisms,by
R6598 T10006 T10008 arg1Of mechanisms,which
R6599 T10006 T10016 arg1Of mechanisms,are
R6600 T10006 T10018 arg1Of mechanisms,elusive
R6601 T10009 T10010 arg1Of A20,regulates
R6602 T10010 T10007 arg1Of regulates,by
R6603 T10012 T10010 arg2Of signalling,regulates
R6604 T10012 T10011 arg1Of signalling,apoptotic
R6605 T10016 T10013 arg1Of are,","
R6606 T10016 T10014 arg1Of are,however
R6607 T10016 T10015 arg1Of are,","
R6608 T10016 T10017 arg1Of are,still
R6609 T10018 T10016 arg2Of elusive,are
R6610 T10020 T10019 arg1Of mice,A20-deficient
R6611 T10020 T10022 arg1Of mice,develop
R6612 T10020 T10028 arg1Of mice,die
R6613 T10020 T10035 arg1Of mice,illustrating
R6614 T10022 T10027 arg1Of develop,and
R6615 T10024 T10025 arg1Of inflammation,and
R6616 T10025 T10022 arg2Of and,develop
R6617 T10025 T10023 arg1Of and,multiorgan
R6618 T10026 T10025 arg2Of cachexia,and
R6619 T10027 T10034 arg1Of and,","
R6620 T10028 T10027 arg2Of die,and
R6621 T10028 T10029 arg1Of die,within
R6622 T10031 T10029 arg2Of weeks,within
R6623 T10031 T10030 arg1Of weeks,2
R6624 T10031 T10032 arg1Of weeks,of
R6625 T10033 T10032 arg2Of birth,of
R6626 T10034 T10021 arg1Of ",",spontaneously
R6627 T10034 T10043 arg1Of ",",[
R6628 T10035 T10034 arg2Of illustrating,","
R6629 T10039 T10035 arg2Of function,illustrating
R6630 T10039 T10036 arg1Of function,the
R6631 T10039 T10037 arg1Of function,potent
R6632 T10039 T10038 arg1Of function,anti-inflammatory
R6633 T10039 T10040 arg1Of function,of
R6634 T10042 T10040 arg2Of molecule,of
R6635 T10042 T10041 arg1Of molecule,this
R6636 T10044 T10043 arg2Of 46,[
R6637 T10045 T10043 arg3Of ],[
R6638 T10047 T10046 arg1Of cells,A20-deficient
R6639 T10047 T10048 arg1Of cells,are
R6640 T10047 T10051 arg1Of cells,susceptible
R6641 T10048 T10049 arg1Of are,also
R6642 T10048 T10055 arg1Of are,","
R6643 T10048 T10056 modOf are,confirming
R6644 T10051 T10048 arg2Of susceptible,are
R6645 T10051 T10050 arg1Of susceptible,more
R6646 T10051 T10052 arg1Of susceptible,to
R6647 T10054 T10052 arg2Of apoptosis,to
R6648 T10054 T10053 arg1Of apoptosis,TNF-mediated
R6649 T10058 T10056 arg2Of role,confirming
R6650 T10058 T10057 arg1Of role,its
R6651 T10058 T10059 arg1Of role,as
R6652 T10062 T10059 arg2Of protein,as
R6653 T10062 T10060 arg1Of protein,an
R6654 T10062 T10061 arg1Of protein,antiapoptotic
R6655 T10063 T10065 arg1Of We,showed
R6656 T10065 T10064 arg1Of showed,recently
R6657 T10067 T10069 arg1Of mice,lacking
R6658 T10067 T10075 arg1Of mice,exhibit
R6659 T10069 T10068 arg1Of lacking,specifically
R6660 T10069 T10071 arg1Of lacking,in
R6661 T10070 T10069 arg2Of A20,lacking
R6662 T10074 T10071 arg2Of cells,in
R6663 T10074 T10072 arg1Of cells,intestinal
R6664 T10074 T10073 arg1Of cells,epithelial
R6665 T10075 T10065 arg2Of exhibit,showed
R6666 T10075 T10066 arg1Of exhibit,that
R6667 T10075 T10093 arg1Of exhibit,","
R6668 T10075 T10094 modOf exhibit,confirming
R6669 T10077 T10075 arg2Of susceptibility,exhibit
R6670 T10077 T10076 arg2Of susceptibility,increased
R6671 T10077 T10078 arg1Of susceptibility,to
R6672 T10077 T10082 arg1Of susceptibility,to
R6673 T10080 T10078 arg2Of colitis,to
R6674 T10080 T10079 arg1Of colitis,experimental
R6675 T10082 T10081 arg1Of to,due
R6676 T10084 T10082 arg2Of hypersensitivity,to
R6677 T10084 T10083 arg1Of hypersensitivity,the
R6678 T10084 T10085 arg1Of hypersensitivity,of
R6679 T10084 T10090 arg1Of hypersensitivity,to
R6680 T10089 T10085 arg2Of cells,of
R6681 T10089 T10086 arg1Of cells,their
R6682 T10089 T10087 arg1Of cells,intestinal
R6683 T10089 T10088 arg1Of cells,epithelial
R6684 T10092 T10090 arg2Of apoptosis,to
R6685 T10092 T10091 arg1Of apoptosis,TNF-induced
R6686 T10094 T10096 arg1Of confirming,as
R6687 T10094 T10105 arg1Of confirming,[
R6688 T10095 T10094 arg2Of A20,confirming
R6689 T10100 T10096 arg2Of protein,as
R6690 T10100 T10097 arg1Of protein,a
R6691 T10100 T10098 arg1Of protein,major
R6692 T10100 T10099 arg1Of protein,antiapoptotic
R6693 T10100 T10101 arg1Of protein,in
R6694 T10104 T10101 arg2Of epithelium,in
R6695 T10104 T10102 arg1Of epithelium,the
R6696 T10104 T10103 arg1Of epithelium,intestinal
R6697 T10106 T10105 arg2Of 47,[
R6698 T10107 T10105 arg3Of ],[
R6699 T10110 T10108 arg1Of studies,Two
R6700 T10110 T10109 arg1Of studies,independent
R6701 T10110 T10111 arg1Of studies,showed
R6702 T10113 T10114 arg1Of mice,lacking
R6703 T10113 T10119 arg1Of mice,develop
R6704 T10114 T10116 arg1Of lacking,in
R6705 T10115 T10114 arg2Of A20,lacking
R6706 T10118 T10116 arg2Of cells,in
R6707 T10118 T10117 arg1Of cells,B
R6708 T10119 T10111 arg2Of develop,showed
R6709 T10119 T10112 arg1Of develop,that
R6710 T10119 T10122 arg1Of develop,to
R6711 T10120 T10119 arg2Of autoimmunity,develop
R6712 T10122 T10121 arg1Of to,due
R6713 T10125 T10122 arg2Of responses,to
R6714 T10125 T10123 arg1Of responses,hyperactive
R6715 T10125 T10124 arg1Of responses,NF-κB
R6716 T10125 T10126 arg1Of responses,in
R6717 T10128 T10126 arg2Of cells,in
R6718 T10128 T10127 arg1Of cells,B
R6719 T10128 T10129 arg1Of cells,leading
R6720 T10129 T10130 arg1Of leading,to
R6721 T10133 T10130 arg2Of survival,to
R6722 T10133 T10131 arg1Of survival,unrestricted
R6723 T10133 T10132 arg1Of survival,B-cell
R6724 T10133 T10134 arg1Of survival,[
R6725 T10135 T10134 arg2Of "48,49",[
R6726 T10136 T10134 arg3Of ],[
R6727 T10138 T10137 arg1Of expression,A20
R6728 T10138 T10139 arg1Of expression,has
R6729 T10138 T10140 arg1Of expression,been
R6730 T10138 T10141 arg2Of expression,observed
R6731 T10141 T10139 arg2Of observed,has
R6732 T10141 T10140 arg2Of observed,been
R6733 T10141 T10142 arg1Of observed,in
R6734 T10145 T10142 arg2Of types,in
R6735 T10145 T10143 arg1Of types,several
R6736 T10145 T10144 arg1Of types,cell
R6737 T10145 T10146 arg1Of types,that
R6738 T10145 T10147 arg1Of types,play
R6739 T10145 T10155 arg1Of types,","
R6740 T10145 T10157 arg1Of types,as
R6741 T10147 T10150 arg1Of play,in
R6742 T10149 T10147 arg2Of roles,play
R6743 T10149 T10148 arg1Of roles,important
R6744 T10152 T10150 arg2Of pathophysiology,in
R6745 T10152 T10151 arg1Of pathophysiology,the
R6746 T10152 T10153 arg1Of pathophysiology,of
R6747 T10154 T10153 arg2Of RA,of
R6748 T10157 T10156 arg1Of as,such
R6749 T10158 T10159 arg1Of fibroblasts,","
R6750 T10159 T10161 arg1Of ",",and
R6751 T10160 T10159 arg2Of synoviocytes,","
R6752 T10161 T10157 arg2Of and,as
R6753 T10162 T10161 arg2Of lymphocytes,and
R6754 T10166 T10165 arg1Of expression,A20
R6755 T10166 T10167 arg1Of expression,is
R6756 T10166 T10169 arg2Of expression,regulated
R6757 T10166 T10176 arg1Of expression,implicating
R6758 T10169 T10163 arg1Of regulated,Interestingly
R6759 T10169 T10164 arg1Of regulated,","
R6760 T10169 T10167 arg2Of regulated,is
R6761 T10169 T10168 arg1Of regulated,itself
R6762 T10169 T10175 arg1Of regulated,","
R6763 T10169 T10176 modOf regulated,implicating
R6764 T10171 T10169 arg1Of NF-κB,regulated
R6765 T10171 T10170 arg2Of NF-κB,by
R6766 T10171 T10172 arg1Of NF-κB,[
R6767 T10173 T10172 arg2Of 50,[
R6768 T10174 T10172 arg3Of ],[
R6769 T10176 T10178 arg1Of implicating,in
R6770 T10177 T10176 arg2Of A20,implicating
R6771 T10182 T10178 arg2Of regulation,in
R6772 T10182 T10179 arg1Of regulation,the
R6773 T10182 T10180 arg1Of regulation,negative
R6774 T10182 T10181 arg1Of regulation,feedback
R6775 T10182 T10183 arg1Of regulation,of
R6776 T10185 T10183 arg2Of signalling,of
R6777 T10185 T10184 arg1Of signalling,NF-κB
R6778 T10189 T10188 arg1Of injection,intra-articular
R6779 T10189 T10190 arg1Of injection,of
R6780 T10189 T10194 arg1Of injection,was
R6781 T10189 T10195 arg2Of injection,shown
R6782 T10189 T10197 arg1Of injection,reduce
R6783 T10193 T10190 arg2Of adenovirus,of
R6784 T10193 T10191 arg1Of adenovirus,an
R6785 T10193 T10192 arg1Of adenovirus,A20-expressing
R6786 T10195 T10186 arg1Of shown,Recently
R6787 T10195 T10187 arg1Of shown,","
R6788 T10195 T10194 arg2Of shown,was
R6789 T10197 T10195 arg3Of reduce,shown
R6790 T10197 T10196 arg1Of reduce,to
R6791 T10197 T10206 arg1Of reduce,in
R6792 T10197 T10213 arg1Of reduce,","
R6793 T10197 T10215 arg1Of reduce,in
R6794 T10197 T10218 arg1Of reduce,","
R6795 T10197 T10219 arg1Of reduce,in
R6796 T10199 T10197 arg2Of severity,reduce
R6797 T10199 T10198 arg1Of severity,the
R6798 T10199 T10200 arg1Of severity,of
R6799 T10202 T10201 arg1Of inflammation,synovial
R6800 T10202 T10203 arg1Of inflammation,and
R6801 T10203 T10200 arg2Of and,of
R6802 T10205 T10203 arg2Of destruction,and
R6803 T10205 T10204 arg1Of destruction,joint
R6804 T10209 T10206 arg2Of model,in
R6805 T10209 T10207 arg1Of model,a
R6806 T10209 T10208 arg1Of model,mouse
R6807 T10209 T10210 arg1Of model,of
R6808 T10212 T10210 arg2Of arthritis,of
R6809 T10212 T10211 arg1Of arthritis,collagen-induced
R6810 T10215 T10214 arg1Of in,even
R6811 T10217 T10215 arg2Of joints,in
R6812 T10217 T10216 arg1Of joints,untreated
R6813 T10222 T10223 arg1Of prophylactic,and
R6814 T10224 T10223 arg2Of therapeutic,and
R6815 T10225 T10219 arg2Of setting,in
R6816 T10225 T10220 arg1Of setting,both
R6817 T10225 T10221 arg1Of setting,a
R6818 T10225 T10222 arg1Of setting,prophylactic
R6819 T10225 T10224 arg1Of setting,therapeutic
R6820 T10227 T10226 arg1Of expression,A20
R6821 T10227 T10228 arg1Of expression,in
R6822 T10227 T10231 arg1Of expression,was
R6823 T10227 T10232 arg2Of expression,associated
R6824 T10230 T10228 arg2Of tissue,in
R6825 T10230 T10229 arg1Of tissue,synovial
R6826 T10232 T10231 arg2Of associated,was
R6827 T10232 T10233 arg1Of associated,with
R6828 T10232 T10258 arg1Of associated,","
R6829 T10232 T10259 modOf associated,suggesting
R6830 T10234 T10233 arg2Of inhibition,with
R6831 T10234 T10235 arg1Of inhibition,of
R6832 T10234 T10241 arg1Of inhibition,of
R6833 T10237 T10236 arg1Of activity,NF-κB
R6834 T10237 T10238 arg1Of activity,and
R6835 T10238 T10235 arg2Of and,of
R6836 T10240 T10238 arg2Of levels,and
R6837 T10240 T10239 arg2Of levels,decreased
R6838 T10242 T10243 arg1Of TNF,","
R6839 T10243 T10245 arg1Of ",",","
R6840 T10244 T10243 arg2Of IL-1β,","
R6841 T10245 T10247 arg1Of ",",","
R6842 T10246 T10245 arg2Of IL-6,","
R6843 T10247 T10250 arg1Of ",",","
R6844 T10249 T10247 arg2Of RANKL,","
R6845 T10249 T10248 arg1Of RANKL,soluble
R6846 T10250 T10256 arg1Of ",",and
R6847 T10253 T10250 arg2Of protein,","
R6848 T10253 T10251 arg1Of protein,monocyte
R6849 T10253 T10252 arg1Of protein,chemo-attractant
R6850 T10253 T10254 arg1Of protein,1
R6851 T10256 T10241 arg2Of and,of
R6852 T10256 T10255 arg1Of and,","
R6853 T10257 T10256 arg2Of IL-17,and
R6854 T10261 T10262 arg1Of A20,induces
R6855 T10262 T10259 arg2Of induces,suggesting
R6856 T10262 T10260 arg1Of induces,that
R6857 T10262 T10266 arg1Of induces,in
R6858 T10262 T10270 arg1Of induces,through
R6859 T10262 T10280 arg1Of induces,[
R6860 T10265 T10262 arg2Of effect,induces
R6861 T10265 T10263 arg1Of effect,a
R6862 T10265 T10264 arg1Of effect,protective
R6863 T10269 T10266 arg2Of mice,in
R6864 T10269 T10267 arg1Of mice,collagen-induced
R6865 T10269 T10268 arg1Of mice,arthritis
R6866 T10271 T10272 arg1Of suppression,of
R6867 T10271 T10275 arg1Of suppression,and
R6868 T10274 T10272 arg2Of activation,of
R6869 T10274 T10273 arg1Of activation,NF-κB
R6870 T10275 T10270 arg2Of and,through
R6871 T10279 T10275 arg2Of expression,and
R6872 T10279 T10276 arg1Of expression,NF-
R6873 T10279 T10277 arg1Of expression,κB-dependent
R6874 T10279 T10278 arg1Of expression,gene
R6875 T10281 T10280 arg2Of 51,[
R6876 T10282 T10280 arg3Of ],[
R6877 T10284 T10285 arg1Of TNF,and
R6878 T10285 T10287 arg1Of and,are
R6879 T10285 T10288 arg2Of and,known
R6880 T10285 T10290 arg1Of and,mediate
R6881 T10286 T10285 arg2Of IL-1β,and
R6882 T10288 T10283 arg2Of known,Because
R6883 T10288 T10287 arg2Of known,are
R6884 T10290 T10288 arg3Of mediate,known
R6885 T10290 T10289 arg1Of mediate,to
R6886 T10291 T10292 arg1Of synovitis,","
R6887 T10292 T10296 arg1Of ",",and
R6888 T10294 T10292 arg2Of formation,","
R6889 T10294 T10293 arg1Of formation,pannus
R6890 T10296 T10290 arg2Of and,mediate
R6891 T10296 T10295 arg1Of and,","
R6892 T10296 T10298 arg1Of and,of
R6893 T10297 T10296 arg2Of erosion,and
R6894 T10299 T10300 arg1Of cartilage,and
R6895 T10300 T10298 arg2Of and,of
R6896 T10300 T10302 arg1Of and,in
R6897 T10301 T10300 arg2Of bone,and
R6898 T10303 T10302 arg2Of RA,in
R6899 T10308 T10305 arg1Of levels,the
R6900 T10308 T10306 arg2Of levels,decreased
R6901 T10308 T10307 arg1Of levels,serum
R6902 T10308 T10309 arg1Of levels,of
R6903 T10308 T10316 arg1Of levels,might
R6904 T10308 T10317 arg1Of levels,explain
R6905 T10310 T10311 arg1Of TNF,and
R6906 T10311 T10309 arg2Of and,of
R6907 T10311 T10313 arg1Of and,in
R6908 T10312 T10311 arg2Of IL-1β,and
R6909 T10315 T10313 arg2Of mice,in
R6910 T10315 T10314 arg1Of mice,A20-transduced
R6911 T10317 T10283 arg1Of explain,Because
R6912 T10317 T10304 arg1Of explain,","
R6913 T10317 T10316 arg2Of explain,might
R6914 T10317 T10321 arg1Of explain,in
R6915 T10320 T10317 arg2Of effects,explain
R6916 T10320 T10318 arg1Of effects,the
R6917 T10320 T10319 arg1Of effects,beneficial
R6918 T10323 T10324 arg1Of clinical,","
R6919 T10324 T10327 arg1Of ",",and
R6920 T10325 T10324 arg2Of pathological,","
R6921 T10327 T10326 arg1Of and,","
R6922 T10328 T10327 arg2Of radiological,and
R6923 T10329 T10321 arg2Of findings,in
R6924 T10329 T10322 arg1Of findings,the
R6925 T10329 T10323 arg1Of findings,clinical
R6926 T10329 T10325 arg1Of findings,pathological
R6927 T10329 T10328 arg1Of findings,radiological
R6928 T10331 T10330 arg1Of study,This
R6929 T10331 T10333 arg1Of study,demonstrated
R6930 T10333 T10332 arg1Of demonstrated,also
R6931 T10336 T10335 arg1Of overexpression,A20
R6932 T10336 T10337 arg1Of overexpression,leads
R6933 T10337 T10333 arg2Of leads,demonstrated
R6934 T10337 T10334 arg1Of leads,that
R6935 T10337 T10338 arg1Of leads,to
R6936 T10340 T10338 arg2Of decrease,to
R6937 T10340 T10339 arg1Of decrease,a
R6938 T10340 T10341 arg1Of decrease,in
R6939 T10343 T10341 arg2Of number,in
R6940 T10343 T10342 arg1Of number,the
R6941 T10343 T10344 arg1Of number,of
R6942 T10343 T10347 arg1Of number,in
R6943 T10346 T10344 arg2Of osteoclasts,of
R6944 T10346 T10345 arg2Of osteoclasts,activated
R6945 T10349 T10347 arg2Of tissue,in
R6946 T10349 T10348 arg1Of tissue,joint
R6947 T10350 T10351 arg1Of A20,might
R6948 T10350 T10353 arg1Of A20,minimise
R6949 T10350 T10357 arg1Of A20,decreasing
R6950 T10353 T10351 arg2Of minimise,might
R6951 T10353 T10352 arg1Of minimise,therefore
R6952 T10353 T10356 arg1Of minimise,through
R6953 T10355 T10353 arg2Of destruction,minimise
R6954 T10355 T10354 arg1Of destruction,joint
R6955 T10357 T10356 arg2Of decreasing,through
R6956 T10360 T10361 arg1Of number,and
R6957 T10361 T10357 arg2Of and,decreasing
R6958 T10361 T10358 arg1Of and,the
R6959 T10361 T10359 arg1Of and,osteoclast
R6960 T10362 T10361 arg2Of activity,and
R6961 T10365 T10364 arg2Of be,will
R6962 T10366 T10365 arg2Of interesting,be
R6963 T10368 T10363 arg1Of analyse,It
R6964 T10368 T10364 arg1Of analyse,will
R6965 T10368 T10365 arg1Of analyse,be
R6966 T10368 T10366 arg1Of analyse,interesting
R6967 T10368 T10367 arg1Of analyse,to
R6968 T10368 T10369 arg1Of analyse,in
R6969 T10370 T10375 arg1Of future,knockout
R6970 T10375 T10371 arg1Of knockout,the
R6971 T10375 T10372 arg1Of knockout,susceptibility
R6972 T10375 T10373 arg1Of knockout,of
R6973 T10375 T10374 arg1Of knockout,conditional
R6974 T10376 T10369 arg2Of mice,in
R6975 T10376 T10370 arg1Of mice,future
R6976 T10377 T10368 arg2Of that,analyse
R6977 T10377 T10378 arg1Of that,lack
R6978 T10378 T10380 arg1Of lack,in
R6979 T10379 T10378 arg2Of A20,lack
R6980 T10383 T10381 arg1Of types,specific
R6981 T10383 T10382 arg1Of types,cell
R6982 T10383 T10385 arg1Of types,as
R6983 T10383 T10393 arg1Of types,","
R6984 T10385 T10384 arg1Of as,such
R6985 T10387 T10386 arg1Of fibroblasts,synovial
R6986 T10387 T10388 arg1Of fibroblasts,","
R6987 T10388 T10390 arg1Of ",",","
R6988 T10389 T10388 arg2Of macrophages,","
R6989 T10390 T10385 arg2Of ",",as
R6990 T10392 T10390 arg2Of cells,","
R6991 T10392 T10391 arg1Of cells,dendritic
R6992 T10393 T10396 arg1Of ",",or
R6993 T10395 T10393 arg2Of cells,","
R6994 T10395 T10394 arg1Of cells,B
R6995 T10396 T10380 arg2Of or,in
R6996 T10398 T10396 arg2Of cells,or
R6997 T10398 T10397 arg1Of cells,T
R6998 T10402 T10401 arg1Of SNPs,several
R6999 T10402 T10403 arg1Of SNPs,in
R7000 T10402 T10408 arg1Of SNPs,have
R7001 T10402 T10409 arg1Of SNPs,been
R7002 T10402 T10410 arg2Of SNPs,associated
R7003 T10407 T10403 arg2Of locus,in
R7004 T10407 T10404 arg1Of locus,the
R7005 T10407 T10405 arg1Of locus,human
R7006 T10407 T10406 arg1Of locus,A20
R7007 T10410 T10399 arg1Of associated,Importantly
R7008 T10410 T10400 arg1Of associated,","
R7009 T10410 T10408 arg2Of associated,have
R7010 T10410 T10409 arg2Of associated,been
R7011 T10410 T10411 arg1Of associated,with
R7012 T10413 T10411 arg2Of susceptibility,with
R7013 T10413 T10412 arg2Of susceptibility,increased
R7014 T10413 T10414 arg1Of susceptibility,to
R7015 T10415 T10414 arg2Of development,to
R7016 T10415 T10416 arg1Of development,of
R7017 T10415 T10419 arg1Of development,(
R7018 T10418 T10416 arg2Of pathologies,of
R7019 T10418 T10417 arg1Of pathologies,autoimmune
R7020 T10420 T10419 arg2Of reviewed,(
R7021 T10420 T10421 arg1Of reviewed,in
R7022 T10420 T10422 arg1Of reviewed,[
R7023 T10423 T10422 arg2Of 52,[
R7024 T10424 T10422 arg3Of ],[
R7025 T10425 T10419 arg3Of ),(
R7026 T10429 T10426 arg1Of studies,Several
R7027 T10429 T10427 arg1Of studies,genome-wide
R7028 T10429 T10428 arg1Of studies,association
R7029 T10429 T10431 arg1Of studies,revealed
R7030 T10431 T10430 arg1Of revealed,also
R7031 T10434 T10432 arg1Of association,a
R7032 T10434 T10433 arg1Of association,clear
R7033 T10434 T10435 arg1Of association,between
R7034 T10434 T10445 arg1Of association,and
R7035 T10436 T10435 arg2Of mutations,between
R7036 T10436 T10437 arg1Of mutations,in
R7037 T10440 T10437 arg2Of locus,in
R7038 T10440 T10438 arg1Of locus,the
R7039 T10440 T10439 arg1Of locus,A20
R7040 T10440 T10441 arg1Of locus,in
R7041 T10444 T10441 arg2Of chromosome,in
R7042 T10444 T10442 arg1Of chromosome,the
R7043 T10444 T10443 arg1Of chromosome,6q23
R7044 T10445 T10431 arg2Of and,revealed
R7045 T10446 T10445 arg2Of susceptibility,and
R7046 T10446 T10447 arg1Of susceptibility,to
R7047 T10448 T10447 arg2Of RA,to
R7048 T10448 T10449 arg1Of RA,[
R7049 T10450 T10449 arg2Of 52,[
R7050 T10451 T10449 arg3Of ],[
R7051 T10455 T10453 arg1Of variants,the
R7052 T10455 T10454 arg2Of variants,identified
R7053 T10455 T10456 arg1Of variants,are
R7054 T10455 T10458 arg2Of variants,located
R7055 T10458 T10452 arg2Of located,Although
R7056 T10458 T10456 arg2Of located,are
R7057 T10458 T10457 arg1Of located,not
R7058 T10458 T10459 arg1Of located,in
R7059 T10461 T10459 arg2Of gene,in
R7060 T10461 T10460 arg1Of gene,a
R7061 T10463 T10464 arg1Of they,are
R7062 T10463 T10465 arg2Of they,thought
R7063 T10463 T10467 arg1Of they,influence
R7064 T10465 T10452 arg1Of thought,Although
R7065 T10465 T10462 arg1Of thought,","
R7066 T10465 T10464 arg2Of thought,are
R7067 T10467 T10465 arg3Of influence,thought
R7068 T10467 T10466 arg1Of influence,to
R7069 T10467 T10469 arg1Of influence,as
R7070 T10467 T10480 arg1Of influence,","
R7071 T10467 T10482 arg1Of influence,by
R7072 T10468 T10467 arg2Of A20,influence
R7073 T10472 T10469 arg2Of gene,as
R7074 T10472 T10470 arg1Of gene,its
R7075 T10472 T10471 arg1Of gene,nearest
R7076 T10472 T10473 arg1Of gene,(
R7077 T10475 T10473 arg2Of kb,(
R7078 T10475 T10474 arg1Of kb,~150
R7079 T10475 T10476 arg1Of kb,downstream
R7080 T10476 T10477 arg1Of downstream,of
R7081 T10478 T10477 arg2Of A20,of
R7082 T10479 T10473 arg3Of ),(
R7083 T10482 T10481 arg1Of by,probably
R7084 T10484 T10482 arg2Of presence,by
R7085 T10484 T10483 arg1Of presence,the
R7086 T10484 T10485 arg1Of presence,of
R7087 T10489 T10485 arg2Of elements,of
R7088 T10489 T10486 arg1Of elements,potential
R7089 T10489 T10487 arg1Of elements,regulatory
R7090 T10489 T10488 arg1Of elements,DNA
R7091 T10489 T10490 arg1Of elements,in
R7092 T10492 T10490 arg2Of region,in
R7093 T10492 T10491 arg1Of region,this
R7094 T10494 T10495 arg1Of A20,is
R7095 T10494 T10496 arg2Of A20,required
R7096 T10496 T10495 arg2Of required,is
R7097 T10496 T10497 arg1Of required,for
R7098 T10496 T10503 arg1Of required,and
R7099 T10498 T10497 arg2Of termination,for
R7100 T10498 T10499 arg1Of termination,of
R7101 T10501 T10499 arg2Of signals,of
R7102 T10501 T10500 arg1Of signals,TNF-induced
R7103 T10503 T10493 arg2Of and,As
R7104 T10503 T10502 arg1Of and,","
R7105 T10504 T10505 arg1Of TNF,is
R7106 T10505 T10503 arg2Of is,and
R7107 T10509 T10505 arg2Of cytokine,is
R7108 T10509 T10506 arg1Of cytokine,the
R7109 T10509 T10507 arg1Of cytokine,primary
R7110 T10509 T10508 arg1Of cytokine,inflammatory
R7111 T10509 T10510 arg1Of cytokine,in
R7112 T10511 T10510 arg2Of RA,in
R7113 T10514 T10513 arg1Of findings,these
R7114 T10514 T10515 arg1Of findings,reveal
R7115 T10515 T10493 arg1Of reveal,As
R7116 T10515 T10512 arg1Of reveal,","
R7117 T10515 T10517 arg1Of reveal,as
R7118 T10516 T10515 arg2Of A20,reveal
R7119 T10521 T10517 arg2Of locus,as
R7120 T10521 T10518 arg1Of locus,a
R7121 T10521 T10519 arg1Of locus,candidate
R7122 T10521 T10520 arg1Of locus,susceptibility
R7123 T10521 T10522 arg1Of locus,for
R7124 T10523 T10522 arg2Of RA,for
R7125 T10526 T10525 arg1Of variants,these
R7126 T10526 T10527 arg1Of variants,affect
R7127 T10526 T10539 arg1Of variants,remain
R7128 T10526 T10540 arg1Of variants,unclear
R7129 T10527 T10536 arg1Of affect,","
R7130 T10530 T10528 arg1Of activity,normal
R7131 T10530 T10529 arg1Of activity,A20
R7132 T10530 T10531 arg1Of activity,and
R7133 T10531 T10527 arg2Of and,affect
R7134 T10532 T10531 arg2Of how,and
R7135 T10533 T10534 arg1Of they,cause
R7136 T10534 T10532 arg1Of cause,how
R7137 T10535 T10534 arg2Of RA,cause
R7138 T10536 T10524 arg1Of ",",How
R7139 T10539 T10536 arg2Of remain,","
R7140 T10539 T10537 arg1Of remain,however
R7141 T10539 T10538 arg1Of remain,","
R7142 T10540 T10539 arg2Of unclear,remain
R7143 T10543 T10544 arg1Of Elsby,and
R7144 T10544 T10547 arg1Of and,evaluated
R7145 T10544 T10563 arg1Of and,could
R7146 T10544 T10564 arg1Of and,show
R7147 T10545 T10544 arg2Of colleagues,and
R7148 T10547 T10549 arg1Of evaluated,vitro
R7149 T10547 T10562 arg1Of evaluated,and
R7150 T10549 T10548 arg1Of vitro,in
R7151 T10552 T10547 arg2Of ability,evaluated
R7152 T10552 T10550 arg1Of ability,the
R7153 T10552 T10551 arg1Of ability,regulatory
R7154 T10552 T10553 arg1Of ability,of
R7155 T10552 T10557 arg1Of ability,on
R7156 T10556 T10553 arg2Of variants,of
R7157 T10556 T10554 arg1Of variants,RA-associated
R7158 T10556 T10555 arg1Of variants,SNP
R7159 T10560 T10557 arg2Of activity,on
R7160 T10560 T10558 arg1Of activity,A20
R7161 T10560 T10559 arg1Of activity,promoter
R7162 T10562 T10541 arg1Of and,Recently
R7163 T10562 T10542 arg1Of and,","
R7164 T10562 T10546 arg1Of and,functionally
R7165 T10562 T10561 arg1Of and,","
R7166 T10564 T10562 arg2Of show,and
R7167 T10564 T10563 arg2Of show,could
R7168 T10567 T10564 arg2Of transcription,show
R7169 T10567 T10565 arg2Of transcription,repressed
R7170 T10567 T10566 arg1Of transcription,A20
R7171 T10567 T10568 arg1Of transcription,for
R7172 T10569 T10568 arg2Of some,for
R7173 T10569 T10570 arg1Of some,of
R7174 T10572 T10570 arg2Of SNPs,of
R7175 T10572 T10571 arg1Of SNPs,the
R7176 T10572 T10573 arg2Of SNPs,investigated
R7177 T10573 T10574 arg1Of investigated,[
R7178 T10575 T10574 arg2Of 53,[
R7179 T10576 T10574 arg3Of ],[
R7180 T10577 T10578 arg1Of It,will
R7181 T10577 T10579 arg1Of It,be
R7182 T10577 T10580 arg1Of It,of
R7183 T10579 T10578 arg2Of be,will
R7184 T10579 T10582 modOf be,to
R7185 T10579 T10589 modOf be,to
R7186 T10580 T10579 arg2Of of,be
R7187 T10581 T10580 arg2Of interest,of
R7188 T10583 T10582 arg1Of identify,to
R7189 T10583 T10588 arg1Of identify,and
R7190 T10587 T10583 arg2Of variants,identify
R7191 T10587 T10584 arg1Of variants,the
R7192 T10587 T10585 arg1Of variants,actual
R7193 T10587 T10586 arg1Of variants,causal
R7194 T10590 T10588 arg2Of elucidate,and
R7195 T10590 T10589 arg1Of elucidate,to
R7196 T10593 T10590 arg2Of consequences,elucidate
R7197 T10593 T10591 arg1Of consequences,the
R7198 T10593 T10592 arg1Of consequences,functional
R7199 T10593 T10594 arg1Of consequences,of
R7200 T10596 T10594 arg2Of variants,of
R7201 T10596 T10595 arg1Of variants,these
R7202 T10599 T10597 arg2Of context,In
R7203 T10599 T10598 arg1Of context,this
R7204 T10602 T10601 arg1Of mice,knockin
R7205 T10602 T10603 arg1Of mice,for
R7206 T10602 T10616 arg1Of mice,will
R7207 T10602 T10617 arg1Of mice,be
R7208 T10607 T10603 arg2Of SNPs,for
R7209 T10607 T10604 arg1Of SNPs,the
R7210 T10607 T10605 arg1Of SNPs,corresponding
R7211 T10607 T10606 arg1Of SNPs,A20
R7212 T10607 T10608 arg1Of SNPs,","
R7213 T10607 T10609 arg2Of SNPs,combined
R7214 T10609 T10610 arg1Of combined,with
R7215 T10612 T10610 arg2Of models,with
R7216 T10612 T10611 arg1Of models,mouse
R7217 T10612 T10613 arg1Of models,for
R7218 T10614 T10613 arg2Of RA,for
R7219 T10617 T10597 arg1Of be,In
R7220 T10617 T10600 arg1Of be,","
R7221 T10617 T10615 arg1Of be,","
R7222 T10617 T10616 arg2Of be,will
R7223 T10619 T10618 arg1Of valuable,very
R7224 T10620 T10617 arg2Of tools,be
R8366 T12738 T12737 arg1Of inhibitors,A20-binding
R8367 T12738 T12739 arg1Of inhibitors,of
R8368 T12740 T12739 arg2Of NF-κB,of
R8369 T12741 T12742 arg1Of ABIN-1,","
R8370 T12742 T12744 arg1Of ",",and
R8371 T12743 T12742 arg2Of ABIN-2,","
R8372 T12744 T12746 arg1Of and,(
R8373 T12744 T12757 arg1Of and,were
R8374 T12744 T12758 arg2Of and,identified
R8375 T12744 T12766 arg1Of and,were
R8376 T12744 T12767 arg2Of and,shown
R8377 T12744 T12769 arg1Of and,inhibit
R8378 T12745 T12744 arg2Of ABIN-3,and
R8379 T12748 T12746 arg2Of known,(
R8380 T12748 T12747 arg1Of known,also
R8381 T12748 T12749 arg1Of known,as
R8382 T12750 T12751 arg1Of TNIP-1,","
R8383 T12751 T12754 arg1Of ",",and
R8384 T12752 T12751 arg2Of TNIP-2,","
R8385 T12754 T12749 arg2Of and,as
R8386 T12754 T12753 arg1Of and,","
R8387 T12755 T12754 arg2Of TNIP-3,and
R8388 T12756 T12746 arg3Of ),(
R8389 T12758 T12757 arg2Of identified,were
R8390 T12758 T12759 arg1Of identified,as
R8391 T12758 T12765 arg1Of identified,and
R8392 T12761 T12760 arg1Of expressed,ubiquitously
R8393 T12764 T12759 arg2Of proteins,as
R8394 T12764 T12761 arg1Of proteins,expressed
R8395 T12764 T12762 arg1Of proteins,A20
R8396 T12764 T12763 arg1Of proteins,interacting
R8397 T12767 T12765 arg2Of shown,and
R8398 T12767 T12766 arg2Of shown,were
R8399 T12769 T12767 arg3Of inhibit,shown
R8400 T12769 T12768 arg1Of inhibit,to
R8401 T12771 T12769 arg2Of activation,inhibit
R8402 T12771 T12770 arg1Of activation,NF-κB
R8403 T12771 T12772 arg1Of activation,by
R8404 T12771 T12779 arg1Of activation,upon
R8405 T12773 T12774 arg1Of TNF,and
R8406 T12777 T12774 arg2Of inflammatory,and
R8407 T12777 T12775 arg1Of inflammatory,several
R8408 T12777 T12776 arg1Of inflammatory,other
R8409 T12778 T12772 arg2Of stimuli,by
R8410 T12778 T12773 arg1Of stimuli,TNF
R8411 T12778 T12777 arg1Of stimuli,inflammatory
R8412 T12780 T12779 arg2Of overexpression,upon
R8413 T12782 T12783 arg1Of ABINs,contain
R8414 T12783 T12781 arg2Of contain,Because
R8415 T12787 T12783 arg2Of motif,contain
R8416 T12787 T12784 arg1Of motif,a
R8417 T12787 T12785 arg1Of motif,specific
R8418 T12787 T12786 arg1Of motif,ubiquitin-binding
R8419 T12789 T12790 arg1Of they,have
R8420 T12789 T12791 arg1Of they,been
R8421 T12789 T12792 arg2Of they,proposed
R8422 T12789 T12794 arg1Of they,target
R8423 T12792 T12781 arg1Of proposed,Because
R8424 T12792 T12788 arg1Of proposed,","
R8425 T12792 T12790 arg2Of proposed,have
R8426 T12792 T12791 arg2Of proposed,been
R8427 T12794 T12792 arg3Of target,proposed
R8428 T12794 T12793 arg1Of target,to
R8429 T12795 T12794 arg2Of A20,target
R8430 T12795 T12796 arg1Of A20,to
R8431 T12798 T12796 arg2Of substrates,to
R8432 T12798 T12797 arg2Of substrates,polyubiquitinated
R8433 T12798 T12799 arg1Of substrates,[
R8434 T12800 T12799 arg2Of "43,44",[
R8435 T12801 T12799 arg3Of ],[
R8436 T12802 T12803 arg1Of Similar,to
R8437 T12804 T12803 arg2Of A20,to
R8438 T12806 T12807 arg1Of ABIN-1,and
R8439 T12807 T12810 arg1Of and,is
R8440 T12809 T12807 arg2Of expression,and
R8441 T12809 T12808 arg1Of expression,ABIN-3
R8442 T12810 T12802 arg1Of is,Similar
R8443 T12810 T12805 arg1Of is,","
R8444 T12810 T12813 arg1Of is,","
R8445 T12810 T12814 modOf is,implicating
R8446 T12811 T12810 arg2Of NF-κB,is
R8447 T12811 T12812 arg1Of NF-κB,dependent
R8448 T12817 T12814 arg2Of role,implicating
R8449 T12817 T12815 arg1Of role,a
R8450 T12817 T12816 arg1Of role,potential
R8451 T12817 T12818 arg1Of role,for
R8452 T12817 T12822 arg1Of role,in
R8453 T12821 T12818 arg2Of complex,for
R8454 T12821 T12819 arg1Of complex,the
R8455 T12821 T12820 arg1Of complex,A20/ABIN
R8456 T12826 T12822 arg2Of regulation,in
R8457 T12826 T12823 arg1Of regulation,the
R8458 T12826 T12824 arg1Of regulation,negative
R8459 T12826 T12825 arg1Of regulation,feedback
R8460 T12826 T12827 arg1Of regulation,of
R8461 T12826 T12830 arg1Of regulation,(
R8462 T12829 T12827 arg2Of activation,of
R8463 T12829 T12828 arg1Of activation,NF-κB
R8464 T12831 T12830 arg2Of reviewed,(
R8465 T12831 T12832 arg1Of reviewed,in
R8466 T12831 T12833 arg1Of reviewed,[
R8467 T12834 T12833 arg2Of 54,[
R8468 T12835 T12833 arg3Of ],[
R8469 T12836 T12830 arg3Of ),(
R8470 T12840 T12841 arg1Of ABIN-1-deficient,and
R8471 T12842 T12841 arg2Of ABIN-2-deficient,and
R8472 T12843 T12839 arg1Of mice,both
R8473 T12843 T12840 arg1Of mice,ABIN-1-deficient
R8474 T12843 T12842 arg1Of mice,ABIN-2-deficient
R8475 T12843 T12844 arg1Of mice,exhibit
R8476 T12843 T12856 arg1Of mice,reflecting
R8477 T12844 T12837 arg1Of exhibit,Unexpectedly
R8478 T12844 T12838 arg1Of exhibit,","
R8479 T12844 T12846 arg1Of exhibit,slightly
R8480 T12844 T12852 arg1Of exhibit,","
R8481 T12844 T12853 arg1Of exhibit,respectively
R8482 T12844 T12854 arg1Of exhibit,","
R8483 T12844 T12856 modOf exhibit,reflecting
R8484 T12846 T12845 arg1Of slightly,only
R8485 T12847 T12848 arg1Of increased,or
R8486 T12849 T12848 arg2Of normal,or
R8487 T12851 T12844 arg2Of responses,exhibit
R8488 T12851 T12847 arg1Of responses,increased
R8489 T12851 T12849 arg1Of responses,normal
R8490 T12851 T12850 arg1Of responses,NF-κB
R8491 T12856 T12855 arg1Of reflecting,possibly
R8492 T12860 T12856 arg2Of activities,reflecting
R8493 T12860 T12857 arg1Of activities,redundant
R8494 T12860 T12858 arg1Of activities,NF-κB
R8495 T12860 T12859 arg1Of activities,inhibitory
R8496 T12860 T12861 arg1Of activities,of
R8497 T12863 T12861 arg2Of ABINs,of
R8498 T12863 T12862 arg1Of ABINs,multiple
R8499 T12863 T12864 arg1Of ABINs,[
R8500 T12865 T12864 arg2Of "55,56",[
R8501 T12866 T12864 arg3Of ],[
R8502 T12868 T12867 arg1Of ABIN-3,Functional
R8503 T12868 T12869 arg1Of ABIN-3,is
R8504 T12868 T12870 arg2Of ABIN-3,expressed
R8505 T12870 T12869 arg2Of expressed,is
R8506 T12870 T12871 arg1Of expressed,in
R8507 T12870 T12874 arg1Of expressed,but
R8508 T12872 T12871 arg2Of humans,in
R8509 T12874 T12873 arg1Of but,","
R8510 T12875 T12877 arg1Of mice,express
R8511 T12877 T12874 arg2Of express,but
R8512 T12877 T12876 arg1Of express,only
R8513 T12879 T12880 arg1Of truncated,and
R8514 T12881 T12880 arg2Of inactive,and
R8515 T12882 T12877 arg2Of form,express
R8516 T12882 T12878 arg1Of form,a
R8517 T12882 T12879 arg1Of form,truncated
R8518 T12882 T12881 arg1Of form,inactive
R8519 T12882 T12883 arg1Of form,lacking
R8520 T12887 T12883 arg2Of domain,lacking
R8521 T12887 T12884 arg1Of domain,the
R8522 T12887 T12885 arg1Of domain,crucial
R8523 T12887 T12886 arg1Of domain,ubiquitin-binding
R8524 T12887 T12888 arg1Of domain,[
R8525 T12889 T12888 arg2Of 57,[
R8526 T12890 T12888 arg3Of ],[
R8527 T12892 T12891 arg1Of for,As
R8528 T12893 T12892 arg2Of A20,for
R8529 T12895 T12898 arg1Of ABIN-1,inhibits
R8530 T12898 T12896 arg1Of inhibits,also
R8531 T12898 T12897 arg1Of inhibits,strongly
R8532 T12898 T12905 arg1Of inhibits,and
R8533 T12900 T12898 arg2Of apoptosis,inhibits
R8534 T12900 T12899 arg1Of apoptosis,TNF-induced
R8535 T12900 T12901 arg1Of apoptosis,[
R8536 T12902 T12901 arg2Of 58,[
R8537 T12903 T12901 arg3Of ],[
R8538 T12905 T12892 arg1Of and,for
R8539 T12905 T12894 arg1Of and,","
R8540 T12905 T12904 arg1Of and,","
R8541 T12908 T12906 arg1Of mice,ABIN-1
R8542 T12908 T12907 arg1Of mice,deficient
R8543 T12908 T12909 arg1Of mice,die
R8544 T12909 T12905 arg2Of die,and
R8545 T12909 T12910 arg1Of die,embryonically
R8546 T12909 T12917 arg1Of die,[
R8547 T12910 T12912 arg1Of embryonically,to
R8548 T12912 T12911 arg1Of to,due
R8549 T12916 T12912 arg2Of apoptosis,to
R8550 T12916 T12913 arg1Of apoptosis,TNF-dependent
R8551 T12916 T12914 arg1Of apoptosis,foetal
R8552 T12916 T12915 arg1Of apoptosis,liver
R8553 T12918 T12917 arg2Of 56,[
R8554 T12919 T12917 arg3Of ],[
R8555 T12923 T12920 arg2Of analysis,Using
R8556 T12923 T12921 arg1Of analysis,oligonucleotide
R8557 T12923 T12922 arg1Of analysis,microarray
R8558 T12925 T12920 arg1Of ABIN-1,Using
R8559 T12925 T12926 arg1Of ABIN-1,was
R8560 T12925 T12927 arg2Of ABIN-1,identified
R8561 T12927 T12926 arg2Of identified,was
R8562 T12927 T12928 arg1Of identified,among
R8563 T12927 T12931 arg1Of identified,in
R8564 T12927 T12935 arg1Of identified,and
R8565 T12930 T12928 arg2Of genes,among
R8566 T12930 T12929 arg1Of genes,TNF-induced
R8567 T12933 T12931 arg2Of synoviocytes,in
R8568 T12933 T12932 arg1Of synoviocytes,human
R8569 T12935 T12920 modOf and,Using
R8570 T12935 T12924 arg1Of and,","
R8571 T12935 T12934 arg1Of and,","
R8572 T12937 T12936 arg1Of levels,high
R8573 T12937 T12938 arg1Of levels,of
R8574 T12937 T12941 arg1Of levels,were
R8575 T12937 T12942 arg2Of levels,detected
R8576 T12940 T12938 arg2Of mRNA,of
R8577 T12940 T12939 arg1Of mRNA,ABIN-1
R8578 T12942 T12935 arg2Of detected,and
R8579 T12942 T12941 arg2Of detected,were
R8580 T12942 T12943 arg1Of detected,in
R8581 T12942 T12947 arg1Of detected,","
R8582 T12942 T12948 modOf detected,indicating
R8583 T12946 T12943 arg2Of biopsies,in
R8584 T12946 T12944 arg1Of biopsies,RA
R8585 T12946 T12945 arg1Of biopsies,tissue
R8586 T12951 T12948 arg2Of role,indicating
R8587 T12951 T12949 arg1Of role,a
R8588 T12951 T12950 arg1Of role,potential
R8589 T12951 T12952 arg1Of role,for
R8590 T12951 T12956 arg1Of role,with
R8591 T12951 T12958 arg1Of role,","
R8592 T12951 T12959 arg1Of role,in
R8593 T12952 T12954 arg1Of for,","
R8594 T12953 T12952 arg2Of ABIN-1,for
R8595 T12956 T12954 arg2Of with,","
R8596 T12956 T12955 arg1Of with,together
R8597 T12957 T12956 arg2Of A20,with
R8598 T12963 T12960 arg1Of regulation,the
R8599 T12963 T12961 arg1Of regulation,negative
R8600 T12963 T12962 arg1Of regulation,feedback
R8601 T12963 T12964 arg1Of regulation,of
R8602 T12963 T12967 arg1Of regulation,and
R8603 T12966 T12964 arg2Of signalling,of
R8604 T12966 T12965 arg1Of signalling,NF-κB
R8605 T12967 T12959 arg2Of and,in
R8606 T12969 T12967 arg2Of pathogenesis,and
R8607 T12969 T12968 arg1Of pathogenesis,the
R8608 T12969 T12970 arg1Of pathogenesis,of
R8609 T12971 T12970 arg2Of RA,of
R8610 T12971 T12972 arg1Of RA,[
R8611 T12973 T12972 arg2Of 59,[
R8612 T12974 T12972 arg3Of ],[
R8613 T12978 T12975 arg2Of study,In
R8614 T12978 T12976 arg1Of study,a
R8615 T12978 T12977 arg1Of study,recent
R8616 T12980 T12981 arg1Of inhibition,of
R8617 T12980 T12984 arg1Of inhibition,by
R8618 T12980 T12994 arg1Of inhibition,was
R8619 T12980 T12995 arg2Of inhibition,shown
R8620 T12980 T12997 arg1Of inhibition,depend
R8621 T12983 T12981 arg2Of responses,of
R8622 T12983 T12982 arg1Of responses,TLR
R8623 T12990 T12989 arg2Of ITAM,(
R8624 T12991 T12989 arg3Of ),(
R8625 T12993 T12984 arg2Of receptors,by
R8626 T12993 T12985 arg1Of receptors,immunoreceptor
R8627 T12993 T12986 arg1Of receptors,tyrosine-based
R8628 T12993 T12987 arg1Of receptors,activation
R8629 T12993 T12988 arg1Of receptors,motif
R8630 T12993 T12989 arg1Of receptors,(
R8631 T12993 T12992 arg1Of receptors,-coupled
R8632 T12995 T12975 arg1Of shown,In
R8633 T12995 T12979 arg1Of shown,","
R8634 T12995 T12994 arg2Of shown,was
R8635 T12997 T12995 arg3Of depend,shown
R8636 T12997 T12996 arg1Of depend,to
R8637 T12997 T12998 arg1Of depend,on
R8638 T13000 T12998 arg2Of expression,on
R8639 T13000 T12999 arg1Of expression,the
R8640 T13000 T13001 arg1Of expression,of
R8641 T13005 T13002 arg1Of proteins,the
R8642 T13005 T13003 arg1Of proteins,NF-κB
R8643 T13005 T13004 arg1Of proteins,inhibitory
R8644 T13006 T13007 arg1Of ABIN-3,and
R8645 T13007 T13001 arg2Of and,of
R8646 T13007 T13005 arg1Of and,proteins
R8647 T13008 T13007 arg2Of A20,and
R8648 T13013 T13011 arg1Of effect,this
R8649 T13013 T13012 arg1Of effect,protective
R8650 T13013 T13014 arg1Of effect,of
R8651 T13013 T13017 arg1Of effect,was
R8652 T13013 T13019 arg2Of effect,suppressed
R8653 T13016 T13014 arg2Of ITAM,of
R8654 T13016 T13015 arg1Of ITAM,the
R8655 T13019 T13009 arg1Of suppressed,Moreover
R8656 T13019 T13010 arg1Of suppressed,","
R8657 T13019 T13017 arg2Of suppressed,was
R8658 T13019 T13018 arg1Of suppressed,strongly
R8659 T13019 T13020 arg1Of suppressed,in
R8660 T13024 T13020 arg2Of macrophages,in
R8661 T13024 T13021 arg1Of macrophages,inflammatory
R8662 T13024 T13022 arg1Of macrophages,arthritis
R8663 T13024 T13023 arg1Of macrophages,synovial
R8664 T13024 T13025 arg1Of macrophages,[
R8665 T13026 T13025 arg2Of 60,[
R8666 T13027 T13025 arg3Of ],[
R8667 T13031 T13030 arg1Of polymorphisms,ABIN-1
R8668 T13031 T13032 arg1Of polymorphisms,have
R8669 T13031 T13033 arg1Of polymorphisms,been
R8670 T13031 T13034 arg2Of polymorphisms,associated
R8671 T13034 T13028 arg1Of associated,Interestingly
R8672 T13034 T13029 arg1Of associated,","
R8673 T13034 T13032 arg2Of associated,have
R8674 T13034 T13033 arg2Of associated,been
R8675 T13034 T13035 arg1Of associated,with
R8676 T13036 T13037 arg1Of psoriasis,and
R8677 T13037 T13035 arg2Of and,with
R8678 T13037 T13041 arg1Of and,in
R8679 T13040 T13037 arg2Of erythematosus,and
R8680 T13040 T13038 arg1Of erythematosus,systemic
R8681 T13040 T13039 arg1Of erythematosus,lupus
R8682 T13042 T13041 arg2Of humans,in
R8683 T13042 T13043 arg1Of humans,[
R8684 T13044 T13043 arg2Of "61,62",[
R8685 T13045 T13043 arg3Of ],[
R8686 T13048 T13046 arg1Of degree,A
R8687 T13048 T13047 arg1Of degree,high
R8688 T13048 T13049 arg1Of degree,of
R8689 T13048 T13051 arg1Of degree,between
R8690 T13048 T13059 arg1Of degree,might
R8691 T13048 T13060 arg1Of degree,be
R8692 T13048 T13061 arg2Of degree,expected
R8693 T13050 T13049 arg2Of overlap,of
R8694 T13054 T13052 arg1Of erythematosus,systemic
R8695 T13054 T13053 arg1Of erythematosus,lupus
R8696 T13054 T13055 arg1Of erythematosus,and
R8697 T13055 T13051 arg2Of and,between
R8698 T13058 T13055 arg2Of loci,and
R8699 T13058 T13056 arg1Of loci,RA
R8700 T13058 T13057 arg1Of loci,susceptibility
R8701 T13061 T13059 arg2Of expected,might
R8702 T13061 T13060 arg2Of expected,be
R8703 T13061 T13062 arg1Of expected,as
R8704 T13065 T13063 arg1Of diseases,the
R8705 T13065 T13064 arg1Of diseases,two
R8706 T13065 T13066 arg1Of diseases,show
R8707 T13066 T13062 arg2Of show,as
R8708 T13066 T13070 arg1Of show,in
R8709 T13069 T13066 arg2Of overlap,show
R8710 T13069 T13067 arg1Of overlap,some
R8711 T13069 T13068 arg1Of overlap,clinical
R8712 T13072 T13071 arg1Of involvement,joint
R8713 T13072 T13073 arg1Of involvement,","
R8714 T13073 T13076 arg1Of ",",","
R8715 T13075 T13073 arg2Of production,","
R8716 T13075 T13074 arg1Of production,autoantibody
R8717 T13076 T13079 arg1Of ",",and
R8718 T13078 T13076 arg2Of features,","
R8719 T13078 T13077 arg1Of features,systemic
R8720 T13079 T13070 arg2Of and,in
R8721 T13080 T13079 arg2Of response,and
R8722 T13080 T13081 arg1Of response,to
R8723 T13082 T13081 arg2Of treatments,to
R8724 T13082 T13084 arg1Of treatments,as
R8725 T13084 T13083 arg1Of as,such
R8726 T13086 T13084 arg2Of depletion,as
R8727 T13086 T13085 arg1Of depletion,B-cell
R8728 T13086 T13087 arg1Of depletion,(
R8729 T13088 T13087 arg2Of rituximab,(
R8730 T13089 T13087 arg3Of ),(
R8731 T13093 T13091 arg2Of be,will
R8732 T13093 T13092 arg1Of be,therefore
R8733 T13094 T13093 arg2Of interesting,be
R8734 T13096 T13090 arg1Of investigate,It
R8735 T13096 T13091 arg1Of investigate,will
R8736 T13096 T13093 arg1Of investigate,be
R8737 T13096 T13094 arg1Of investigate,interesting
R8738 T13096 T13095 arg1Of investigate,to
R8739 T13098 T13099 arg1Of SNPs,that
R8740 T13098 T13100 arg1Of SNPs,have
R8741 T13098 T13101 arg1Of SNPs,been
R8742 T13098 T13102 arg2Of SNPs,reported
R8743 T13098 T13104 arg1Of SNPs,be
R8744 T13098 T13105 arg2Of SNPs,associated
R8745 T13098 T13110 arg1Of SNPs,are
R8746 T13098 T13112 arg2Of SNPs,associated
R8747 T13102 T13100 arg2Of reported,have
R8748 T13102 T13101 arg2Of reported,been
R8749 T13105 T13102 arg3Of associated,reported
R8750 T13105 T13103 arg1Of associated,to
R8751 T13105 T13104 arg2Of associated,be
R8752 T13105 T13106 arg1Of associated,with
R8753 T13109 T13106 arg2Of erythematosus,with
R8754 T13109 T13107 arg1Of erythematosus,systemic
R8755 T13109 T13108 arg1Of erythematosus,lupus
R8756 T13112 T13096 arg2Of associated,investigate
R8757 T13112 T13097 arg1Of associated,whether
R8758 T13112 T13110 arg2Of associated,are
R8759 T13112 T13111 arg1Of associated,also
R8760 T13112 T13113 arg1Of associated,with
R8761 T13114 T13113 arg2Of RA,with
R9347 T14245 T14244 arg1Of protein,Cylindromatosis
R9348 T14246 T14247 arg1Of Cylindromatosis,(
R9349 T14248 T14247 arg2Of CYLD,(
R9350 T14249 T14247 arg3Of ),(
R9351 T14250 T14246 arg1Of protein,Cylindromatosis
R9352 T14250 T14251 arg1Of protein,was
R9353 T14250 T14253 arg2Of protein,identified
R9354 T14253 T14251 arg2Of identified,was
R9355 T14253 T14252 arg1Of identified,originally
R9356 T14253 T14254 arg1Of identified,as
R9357 T14257 T14254 arg2Of suppressor,as
R9358 T14257 T14255 arg1Of suppressor,a
R9359 T14257 T14256 arg1Of suppressor,tumour
R9360 T14257 T14258 arg2Of suppressor,involved
R9361 T14258 T14259 arg1Of involved,in
R9362 T14261 T14259 arg2Of cylindromatosis,in
R9363 T14261 T14260 arg1Of cylindromatosis,familial
R9364 T14261 T14262 arg1Of cylindromatosis,[
R9365 T14263 T14262 arg2Of 63,[
R9366 T14264 T14262 arg3Of ],[
R9367 T14265 T14266 arg1Of CYLD,is
R9368 T14265 T14268 arg2Of CYLD,involved
R9369 T14268 T14266 arg2Of involved,is
R9370 T14268 T14267 arg1Of involved,also
R9371 T14268 T14269 arg1Of involved,","
R9372 T14268 T14270 arg1Of involved,however
R9373 T14268 T14271 arg1Of involved,","
R9374 T14268 T14272 arg1Of involved,in
R9375 T14275 T14272 arg2Of processes,in
R9376 T14275 T14273 arg1Of processes,diverse
R9377 T14275 T14274 arg1Of processes,physiological
R9378 T14275 T14276 arg1Of processes,ranging
R9379 T14276 T14277 arg1Of ranging,from
R9380 T14276 T14281 arg1Of ranging,to
R9381 T14278 T14279 arg1Of immunity,and
R9382 T14279 T14277 arg2Of and,from
R9383 T14280 T14279 arg2Of inflammation,and
R9384 T14284 T14282 arg1Of progression,cell
R9385 T14284 T14283 arg1Of progression,cycle
R9386 T14284 T14285 arg1Of progression,","
R9387 T14285 T14288 arg1Of ",",and
R9388 T14286 T14285 arg2Of spermatogenesis,","
R9389 T14288 T14281 arg2Of and,to
R9390 T14288 T14287 arg1Of and,","
R9391 T14289 T14288 arg2Of osteoclastogenesis,and
R9392 T14289 T14290 arg1Of osteoclastogenesis,(
R9393 T14291 T14290 arg2Of reviewed,(
R9394 T14291 T14292 arg1Of reviewed,in
R9395 T14291 T14293 arg1Of reviewed,[
R9396 T14294 T14293 arg2Of 64,[
R9397 T14295 T14293 arg3Of ],[
R9398 T14296 T14290 arg3Of ),(
R9399 T14297 T14298 arg1Of CYLD,is
R9400 T14298 T14327 arg1Of is,","
R9401 T14298 T14328 arg1Of is,by
R9402 T14301 T14298 arg2Of enzyme,is
R9403 T14301 T14299 arg1Of enzyme,a
R9404 T14301 T14300 arg1Of enzyme,deubiquitinating
R9405 T14301 T14302 arg1Of enzyme,that
R9406 T14301 T14304 arg1Of enzyme,regulates
R9407 T14304 T14303 arg1Of regulates,negatively
R9408 T14306 T14304 arg2Of signalling,regulates
R9409 T14306 T14305 arg1Of signalling,NF-κB
R9410 T14306 T14307 arg2Of signalling,initiated
R9411 T14306 T14316 arg1Of signalling,(
R9412 T14306 T14323 arg1Of signalling,(
R9413 T14309 T14310 arg1Of TNFR,","
R9414 T14310 T14312 arg1Of ",",and
R9415 T14311 T14310 arg2Of RANK,","
R9416 T14312 T14307 arg1Of and,initiated
R9417 T14312 T14308 arg2Of and,by
R9418 T14315 T14312 arg2Of stimulation,and
R9419 T14315 T14313 arg1Of stimulation,T-cell
R9420 T14315 T14314 arg1Of stimulation,receptor
R9421 T14317 T14316 arg2Of reviewed,(
R9422 T14317 T14318 arg1Of reviewed,in
R9423 T14317 T14319 arg1Of reviewed,[
R9424 T14320 T14319 arg2Of 64,[
R9425 T14321 T14319 arg3Of ],[
R9426 T14322 T14316 arg3Of ),(
R9427 T14324 T14323 arg2Of Figure,(
R9428 T14324 T14325 arg1Of Figure,1
R9429 T14326 T14323 arg3Of ),(
R9430 T14333 T14328 arg2Of proteins,by
R9431 T14333 T14329 arg1Of proteins,deubiquitina-ting
R9432 T14333 T14330 arg1Of proteins,several
R9433 T14333 T14331 arg1Of proteins,NF-κB
R9434 T14333 T14332 arg1Of proteins,signalling
R9435 T14333 T14334 arg1Of proteins,including
R9436 T14335 T14336 arg1Of NEMO,","
R9437 T14336 T14338 arg1Of ",",","
R9438 T14337 T14336 arg2Of TRAF2,","
R9439 T14338 T14340 arg1Of ",",","
R9440 T14339 T14338 arg2Of TRAF6,","
R9441 T14340 T14342 arg1Of ",",","
R9442 T14341 T14340 arg2Of TRAF7,","
R9443 T14342 T14344 arg1Of ",",and
R9444 T14343 T14342 arg2Of RIP1,","
R9445 T14344 T14334 arg2Of and,including
R9446 T14345 T14344 arg2Of TAK1,and
R9447 T14346 T14347 arg1Of Many,of
R9448 T14346 T14349 arg1Of Many,are
R9449 T14346 T14351 arg2Of Many,targeted
R9450 T14348 T14347 arg2Of these,of
R9451 T14351 T14349 arg2Of targeted,are
R9452 T14351 T14350 arg1Of targeted,also
R9453 T14351 T14354 arg1Of targeted,and
R9454 T14353 T14351 arg1Of A20,targeted
R9455 T14353 T14352 arg2Of A20,by
R9456 T14356 T14354 arg2Of is,and
R9457 T14356 T14357 arg1Of is,still
R9458 T14356 T14358 arg1Of is,not
R9459 T14359 T14356 arg2Of clear,is
R9460 T14360 T14355 arg1Of why,it
R9461 T14360 T14356 arg1Of why,is
R9462 T14360 T14359 arg1Of why,clear
R9463 T14362 T14361 arg1Of cell,the
R9464 T14362 T14363 arg1Of cell,needs
R9465 T14363 T14360 arg1Of needs,why
R9466 T14363 T14369 modOf needs,to
R9467 T14364 T14367 arg1Of A20,as
R9468 T14367 T14363 arg2Of as,needs
R9469 T14367 T14365 arg1Of as,as
R9470 T14367 T14366 arg1Of as,well
R9471 T14368 T14367 arg2Of CYLD,as
R9472 T14370 T14369 arg1Of control,to
R9473 T14372 T14370 arg2Of activation,control
R9474 T14372 T14371 arg1Of activation,NF-κB
R9475 T14374 T14375 arg1Of A20,is
R9476 T14374 T14377 arg2Of A20,expressed
R9477 T14377 T14373 arg2Of expressed,As
R9478 T14377 T14375 arg2Of expressed,is
R9479 T14377 T14376 arg1Of expressed,only
R9480 T14377 T14378 arg1Of expressed,in
R9481 T14377 T14382 arg1Of expressed,upon
R9482 T14381 T14378 arg2Of types,in
R9483 T14381 T14379 arg1Of types,many
R9484 T14381 T14380 arg1Of types,cell
R9485 T14383 T14382 arg2Of stimulation,upon
R9486 T14385 T14386 arg1Of it,has
R9487 T14385 T14387 arg1Of it,been
R9488 T14385 T14388 arg2Of it,suggested
R9489 T14388 T14373 arg1Of suggested,As
R9490 T14388 T14384 arg1Of suggested,","
R9491 T14388 T14386 arg2Of suggested,has
R9492 T14388 T14387 arg2Of suggested,been
R9493 T14391 T14390 arg1Of protein,this
R9494 T14391 T14393 arg1Of protein,regulates
R9495 T14393 T14392 arg1Of regulates,mainly
R9496 T14393 T14400 arg1Of regulates,whereas
R9497 T14395 T14393 arg2Of phases,regulates
R9498 T14395 T14394 arg1Of phases,later
R9499 T14395 T14396 arg1Of phases,of
R9500 T14398 T14396 arg2Of signalling,of
R9501 T14398 T14397 arg1Of signalling,NF-κB
R9502 T14400 T14388 arg3Of whereas,suggested
R9503 T14400 T14389 arg1Of whereas,that
R9504 T14400 T14399 arg1Of whereas,","
R9505 T14401 T14402 arg1Of CYLD,would
R9506 T14401 T14403 arg1Of CYLD,regulate
R9507 T14403 T14400 arg2Of regulate,whereas
R9508 T14403 T14402 arg2Of regulate,would
R9509 T14404 T14405 arg1Of constitutive,and
R9510 T14406 T14405 arg2Of early,and
R9511 T14407 T14403 arg2Of signalling,regulate
R9512 T14407 T14404 arg1Of signalling,constitutive
R9513 T14407 T14406 arg1Of signalling,early
R9514 T14409 T14408 arg2Of addition,In
R9515 T14413 T14411 arg1Of activity,their
R9516 T14413 T14412 arg1Of activity,relative
R9517 T14413 T14414 arg1Of activity,might
R9518 T14413 T14416 arg1Of activity,be
R9519 T14413 T14418 arg1Of activity,dependent
R9520 T14416 T14408 arg1Of be,In
R9521 T14416 T14410 arg1Of be,","
R9522 T14416 T14414 arg2Of be,might
R9523 T14416 T14415 arg1Of be,also
R9524 T14416 T14419 arg1Of be,[
R9525 T14418 T14416 arg2Of dependent,be
R9526 T14418 T14417 arg1Of dependent,cell-type
R9527 T14420 T14419 arg2Of 64,[
R9528 T14421 T14419 arg3Of ],[
R9529 T14424 T14425 arg1Of CYLD,has
R9530 T14424 T14426 arg1Of CYLD,been
R9531 T14424 T14427 arg2Of CYLD,shown
R9532 T14424 T14430 arg1Of CYLD,regulate
R9533 T14427 T14422 arg1Of shown,Interestingly
R9534 T14427 T14423 arg1Of shown,","
R9535 T14427 T14425 arg2Of shown,has
R9536 T14427 T14426 arg2Of shown,been
R9537 T14430 T14427 arg3Of regulate,shown
R9538 T14430 T14428 arg1Of regulate,to
R9539 T14430 T14429 arg1Of regulate,negatively
R9540 T14432 T14431 arg1Of signalling,RANK
R9541 T14432 T14433 arg1Of signalling,and
R9542 T14433 T14430 arg2Of and,regulate
R9543 T14433 T14435 arg1Of and,in
R9544 T14434 T14433 arg2Of osteoclastogenesis,and
R9545 T14436 T14435 arg2Of mice,in
R9546 T14436 T14437 arg1Of mice,[
R9547 T14438 T14437 arg2Of 65,[
R9548 T14439 T14437 arg3Of ],[
R9549 T14440 T14441 arg1Of Mice,with
R9550 T14440 T14447 arg1Of Mice,have
R9551 T14440 T14452 arg1Of Mice,develop
R9552 T14444 T14441 arg2Of deficiency,with
R9553 T14444 T14442 arg1Of deficiency,a
R9554 T14444 T14443 arg1Of deficiency,genetic
R9555 T14444 T14445 arg1Of deficiency,of
R9556 T14446 T14445 arg2Of CYLD,of
R9557 T14447 T14451 arg1Of have,and
R9558 T14450 T14447 arg2Of differentiation,have
R9559 T14450 T14448 arg1Of differentiation,aberrant
R9560 T14450 T14449 arg1Of differentiation,osteoclast
R9561 T14452 T14451 arg2Of develop,and
R9562 T14454 T14452 arg2Of osteoporosis,develop
R9563 T14454 T14453 arg1Of osteoporosis,severe
R9564 T14456 T14455 arg1Of precursors,Osteoclast
R9565 T14456 T14457 arg1Of precursors,of
R9566 T14456 T14460 arg1Of precursors,are
R9567 T14456 T14461 arg1Of precursors,hyper-responsive
R9568 T14456 T14466 arg1Of precursors,produce
R9569 T14459 T14457 arg2Of mice,of
R9570 T14459 T14458 arg1Of mice,these
R9571 T14460 T14465 arg1Of are,and
R9572 T14461 T14460 arg2Of hyper-responsive,are
R9573 T14461 T14462 arg1Of hyper-responsive,to
R9574 T14464 T14462 arg2Of differentiation,to
R9575 T14464 T14463 arg1Of differentiation,RANKL-induced
R9576 T14466 T14465 arg2Of produce,and
R9577 T14467 T14468 arg1Of more,and
R9578 T14469 T14468 arg2Of larger,and
R9579 T14470 T14466 arg2Of osteoclasts,produce
R9580 T14470 T14467 arg1Of osteoclasts,more
R9581 T14470 T14469 arg1Of osteoclasts,larger
R9582 T14472 T14471 arg1Of expression,CYLD
R9583 T14472 T14473 arg1Of expression,is
R9584 T14472 T14475 arg2Of expression,upregulated
R9585 T14472 T14482 arg1Of expression,is
R9586 T14472 T14483 arg2Of expression,recruited
R9587 T14475 T14473 arg2Of upregulated,is
R9588 T14475 T14474 arg1Of upregulated,markedly
R9589 T14475 T14476 arg1Of upregulated,under
R9590 T14475 T14481 arg1Of upregulated,and
R9591 T14477 T14476 arg2Of conditions,under
R9592 T14477 T14478 arg1Of conditions,of
R9593 T14480 T14478 arg2Of osteoclastogenesis,of
R9594 T14480 T14479 arg1Of osteoclastogenesis,RANKL-induced
R9595 T14481 T14503 arg1Of and,","
R9596 T14481 T14504 modOf and,followed
R9597 T14483 T14481 arg2Of recruited,and
R9598 T14483 T14482 arg2Of recruited,is
R9599 T14483 T14484 arg1Of recruited,to
R9600 T14483 T14487 arg1Of recruited,via
R9601 T14483 T14500 arg1Of recruited,[
R9602 T14486 T14484 arg2Of TRAF6,to
R9603 T14486 T14485 arg2Of TRAF6,ubiquitinated
R9604 T14492 T14487 arg2Of p62,via
R9605 T14492 T14488 arg1Of p62,the
R9606 T14492 T14489 arg1Of p62,ubiquitin-binding
R9607 T14492 T14490 arg1Of p62,adaptor
R9608 T14492 T14491 arg1Of p62,protein
R9609 T14492 T14493 arg1Of p62,(
R9610 T14495 T14493 arg2Of known,(
R9611 T14495 T14494 arg1Of known,also
R9612 T14495 T14496 arg1Of known,as
R9613 T14497 T14496 arg2Of sequestosome,as
R9614 T14497 T14498 arg1Of sequestosome,1
R9615 T14499 T14493 arg3Of ),(
R9616 T14501 T14500 arg2Of 65,[
R9617 T14502 T14500 arg3Of ],[
R9618 T14508 T14504 arg1Of deubiquitination,followed
R9619 T14508 T14505 arg2Of deubiquitination,by
R9620 T14508 T14506 arg1Of deubiquitination,the
R9621 T14508 T14507 arg1Of deubiquitination,CYLD-mediated
R9622 T14508 T14509 arg1Of deubiquitination,of
R9623 T14510 T14509 arg2Of TRAF6,of
R9624 T14513 T14511 arg2Of context,In
R9625 T14513 T14512 arg1Of context,this
R9629 T14516 T14514 arg1Of is,","
R9630 T14517 T14516 arg2Of worth,is
R9631 T14518 T14517 arg2Of mentioning,worth
R9632 T14521 T14520 arg1Of mice,transgenic
R9633 T14521 T14522 arg1Of mice,expressing
R9634 T14521 T14529 arg1Of mice,display
R9635 T14521 T14533 arg1Of mice,develop
R9636 T14525 T14522 arg2Of form,expressing
R9637 T14525 T14523 arg1Of form,a
R9638 T14525 T14524 arg2Of form,mutated
R9639 T14525 T14526 arg1Of form,of
R9640 T14527 T14526 arg2Of p62,of
R9641 T14529 T14532 arg1Of display,and
R9642 T14531 T14529 arg2Of osteoclastogenesis,display
R9643 T14531 T14530 arg1Of osteoclastogenesis,abnormal
R9644 T14532 T14518 arg2Of and,mentioning
R9645 T14532 T14519 arg1Of and,that
R9646 T14532 T14528 arg1Of and,also
R9647 T14533 T14532 arg2Of develop,and
R9648 T14533 T14537 arg1Of develop,[
R9649 T14536 T14533 arg2Of loss,develop
R9650 T14536 T14534 arg1Of loss,progressive
R9651 T14536 T14535 arg1Of loss,bone
R9652 T14538 T14537 arg2Of 66,[
R9653 T14539 T14537 arg3Of ],[
R9654 T14541 T14540 arg1Of findings,These
R9655 T14541 T14542 arg1Of findings,suggest
R9656 T14545 T14544 arg1Of inhibi-tion,CYLD-mediated
R9657 T14545 T14546 arg1Of inhibi-tion,of
R9658 T14545 T14550 arg1Of inhibi-tion,plays
R9659 T14545 T14561 arg1Of inhibi-tion,indicate
R9660 T14549 T14546 arg2Of signalling,of
R9661 T14549 T14547 arg1Of signalling,RANK-induced
R9662 T14549 T14548 arg1Of signalling,NF-κB
R9663 T14550 T14554 arg1Of plays,in
R9664 T14550 T14560 arg1Of plays,and
R9665 T14553 T14550 arg2Of role,plays
R9666 T14553 T14551 arg1Of role,a
R9667 T14553 T14552 arg1Of role,key
R9668 T14557 T14554 arg2Of regulation,in
R9669 T14557 T14555 arg1Of regulation,the
R9670 T14557 T14556 arg1Of regulation,negative
R9671 T14557 T14558 arg1Of regulation,of
R9672 T14559 T14558 arg2Of osteoclastogenesis,of
R9673 T14560 T14542 arg2Of and,suggest
R9674 T14560 T14543 arg1Of and,that
R9675 T14561 T14560 arg2Of indicate,and
R9676 T14561 T14563 arg1Of indicate,as
R9677 T14562 T14561 arg2Of CYLD,indicate
R9678 T14567 T14563 arg2Of factor,as
R9679 T14567 T14564 arg1Of factor,a
R9680 T14567 T14565 arg1Of factor,potential
R9681 T14567 T14566 arg1Of factor,genetic
R9682 T14567 T14568 arg2Of factor,involved
R9683 T14568 T14569 arg1Of involved,in
R9684 T14571 T14569 arg2Of pathology,in
R9685 T14571 T14570 arg1Of pathology,the
R9686 T14571 T14572 arg1Of pathology,of
R9687 T14574 T14572 arg2Of disorders,of
R9688 T14574 T14573 arg1Of disorders,bone
R9689 T14574 T14576 arg1Of disorders,as
R9690 T14576 T14575 arg1Of as,such
R9691 T14577 T14576 arg2Of RA,as
R10202 T15550 T15547 arg1Of protein,Single-immunoglobulin
R10203 T15550 T15548 arg1Of protein,IL-1
R10204 T15550 T15549 arg1Of protein,receptor-related
R10205 T15555 T15554 arg2Of SIGIRR,(
R10206 T15556 T15554 arg3Of ),(
R10207 T15557 T15551 arg1Of protein,Single-immunoglobulin
R10208 T15557 T15552 arg1Of protein,IL-1
R10209 T15557 T15553 arg1Of protein,receptor-related
R10210 T15557 T15554 arg1Of protein,(
R10211 T15557 T15558 arg1Of protein,","
R10212 T15557 T15559 arg1Of protein,also
R10213 T15557 T15560 arg2Of protein,known
R10214 T15557 T15564 arg1Of protein,is
R10215 T15560 T15561 arg1Of known,as
R10216 T15562 T15561 arg2Of TIR-8,as
R10217 T15564 T15563 arg1Of is,","
R10218 T15566 T15564 arg2Of member,is
R10219 T15566 T15565 arg1Of member,a
R10220 T15566 T15567 arg1Of member,of
R10221 T15570 T15567 arg2Of family,of
R10222 T15570 T15568 arg1Of family,the
R10223 T15570 T15569 arg1Of family,TLR/IL-1R
R10224 T15570 T15571 arg1Of family,that
R10225 T15570 T15572 arg1Of family,has
R10226 T15570 T15573 arg1Of family,been
R10227 T15570 T15575 arg2Of family,characterised
R10228 T15575 T15572 arg2Of characterised,has
R10229 T15575 T15573 arg2Of characterised,been
R10230 T15575 T15574 arg1Of characterised,extensively
R10231 T15575 T15576 arg1Of characterised,as
R10232 T15575 T15584 arg1Of characterised,","
R10233 T15575 T15586 arg1Of characterised,through
R10234 T15575 T15598 arg1Of characterised,[
R10235 T15575 T15601 arg1Of characterised,(
R10236 T15578 T15576 arg2Of inhibitor,as
R10237 T15578 T15577 arg1Of inhibitor,an
R10238 T15578 T15579 arg1Of inhibitor,of
R10239 T15580 T15581 arg1Of IL-1R,and
R10240 T15582 T15581 arg2Of TLR,and
R10241 T15583 T15579 arg2Of signalling,of
R10242 T15583 T15580 arg1Of signalling,IL-1R
R10243 T15583 T15582 arg1Of signalling,TLR
R10244 T15586 T15585 arg1Of through,probably
R10245 T15588 T15587 arg1Of interaction,direct
R10246 T15588 T15589 arg1Of interaction,with
R10247 T15588 T15594 arg1Of interaction,","
R10248 T15591 T15589 arg2Of receptors,with
R10249 T15591 T15590 arg1Of receptors,these
R10250 T15591 T15592 arg1Of receptors,","
R10251 T15593 T15592 arg2Of MyD88,","
R10252 T15594 T15596 arg1Of ",",or
R10253 T15595 T15594 arg2Of IRAK1,","
R10254 T15596 T15586 arg2Of or,through
R10255 T15597 T15596 arg2Of TRAF6,or
R10256 T15599 T15598 arg2Of 67,[
R10257 T15600 T15598 arg3Of ],[
R10258 T15602 T15601 arg2Of Figure,(
R10259 T15602 T15603 arg1Of Figure,1
R10260 T15604 T15601 arg3Of ),(
R10261 T15608 T15605 arg2Of role,Given
R10262 T15608 T15606 arg1Of role,the
R10263 T15608 T15607 arg1Of role,important
R10264 T15608 T15609 arg1Of role,of
R10265 T15608 T15614 arg1Of role,in
R10266 T15610 T15611 arg1Of IL-1R,and
R10267 T15612 T15611 arg2Of TLR,and
R10268 T15613 T15609 arg2Of signalling,of
R10269 T15613 T15610 arg1Of signalling,IL-1R
R10270 T15613 T15612 arg1Of signalling,TLR
R10271 T15617 T15614 arg2Of inflammation,in
R10272 T15617 T15615 arg1Of inflammation,the
R10273 T15617 T15616 arg1Of inflammation,chronic
R10274 T15617 T15618 arg2Of inflammation,observed
R10275 T15618 T15619 arg1Of observed,in
R10276 T15620 T15619 arg2Of RA,in
R10277 T15620 T15621 arg1Of RA,[
R10278 T15622 T15621 arg2Of 68,[
R10279 T15623 T15621 arg3Of ],[
R10280 T15627 T15625 arg1Of role,a
R10281 T15627 T15626 arg1Of role,regulatory
R10282 T15627 T15628 arg1Of role,for
R10283 T15627 T15630 arg1Of role,in
R10284 T15627 T15632 arg1Of role,is
R10285 T15627 T15634 arg1Of role,unlikely
R10286 T15629 T15628 arg2Of SIGIRR,for
R10287 T15631 T15630 arg2Of RA,in
R10288 T15632 T15605 arg1Of is,Given
R10289 T15632 T15624 arg1Of is,","
R10290 T15632 T15633 arg1Of is,not
R10291 T15634 T15632 arg2Of unlikely,is
R10292 T15635 T15636 arg1Of SIGIRR,has
R10293 T15635 T15643 arg1Of SIGIRR,being
R10294 T15635 T15644 arg2Of SIGIRR,expressed
R10295 T15636 T15642 arg1Of has,","
R10296 T15639 T15638 arg1Of restricted,very
R10297 T15641 T15636 arg2Of pattern,has
R10298 T15641 T15637 arg1Of pattern,a
R10299 T15641 T15639 arg1Of pattern,restricted
R10300 T15641 T15640 arg1Of pattern,expression
R10301 T15644 T15642 arg2Of expressed,","
R10302 T15644 T15643 arg2Of expressed,being
R10303 T15644 T15645 arg1Of expressed,in
R10304 T15644 T15657 arg1Of expressed,in
R10305 T15644 T15660 arg1Of expressed,[
R10306 T15645 T15655 arg1Of in,but
R10307 T15647 T15646 arg1Of cells,epithelial
R10308 T15647 T15648 arg1Of cells,","
R10309 T15648 T15650 arg1Of ",",and
R10310 T15649 T15648 arg2Of monocytes,","
R10311 T15650 T15645 arg2Of and,in
R10312 T15653 T15650 arg2Of cells,and
R10313 T15653 T15651 arg1Of cells,immature
R10314 T15653 T15652 arg1Of cells,dendritic
R10315 T15655 T15654 arg1Of but,","
R10316 T15657 T15655 arg2Of in,but
R10317 T15657 T15656 arg1Of in,not
R10318 T15659 T15657 arg2Of macro-phages,in
R10319 T15659 T15658 arg1Of macro-phages,mature
R10320 T15661 T15660 arg2Of "69,70",[
R10321 T15662 T15660 arg3Of ],[
R10322 T15666 T15665 arg1Of overexpression,SIGIRR
R10323 T15666 T15667 arg1Of overexpression,was
R10324 T15666 T15668 arg2Of overexpression,shown
R10325 T15666 T15670 arg1Of overexpression,inhibit
R10326 T15668 T15663 arg1Of shown,Recently
R10327 T15668 T15664 arg1Of shown,","
R10328 T15668 T15667 arg2Of shown,was
R10329 T15670 T15668 arg3Of inhibit,shown
R10330 T15670 T15669 arg1Of inhibit,to
R10331 T15673 T15670 arg2Of release,inhibit
R10332 T15673 T15671 arg1Of release,the
R10333 T15673 T15672 arg1Of release,spontaneous
R10334 T15673 T15674 arg1Of release,of
R10335 T15673 T15677 arg1Of release,by
R10336 T15676 T15674 arg2Of cytokines,of
R10337 T15676 T15675 arg1Of cytokines,inflammatory
R10338 T15681 T15677 arg2Of cells,by
R10339 T15681 T15678 arg1Of cells,human
R10340 T15681 T15679 arg1Of cells,RA
R10341 T15681 T15680 arg1Of cells,synovial
R10342 T15684 T15682 arg1Of function,This
R10343 T15684 T15683 arg1Of function,inhibitory
R10344 T15684 T15685 arg1Of function,of
R10345 T15684 T15687 arg1Of function,was
R10346 T15684 T15689 arg2Of function,confirmed
R10347 T15686 T15685 arg2Of SIGIRR,of
R10348 T15689 T15687 arg2Of confirmed,was
R10349 T15689 T15688 arg1Of confirmed,further
R10350 T15689 T15691 arg1Of confirmed,vivo
R10351 T15689 T15692 arg1Of confirmed,","
R10352 T15689 T15693 arg1Of confirmed,since
R10353 T15691 T15690 arg1Of vivo,in
R10354 T15695 T15694 arg1Of mice,SIGIRR-deficient
R10355 T15695 T15696 arg1Of mice,developed
R10356 T15696 T15693 arg2Of developed,since
R10357 T15696 T15712 arg1Of developed,[
R10358 T15699 T15698 arg1Of severe,more
R10359 T15700 T15697 arg1Of disease,a
R10360 T15700 T15699 arg1Of disease,severe
R10361 T15700 T15701 arg1Of disease,in
R10362 T15700 T15707 arg1Of disease,as
R10363 T15703 T15701 arg2Of arthritis,in
R10364 T15703 T15702 arg1Of arthritis,zymosan-induced
R10365 T15707 T15696 arg2Of as,developed
R10366 T15707 T15704 arg1Of as,","
R10367 T15707 T15705 arg1Of as,as
R10368 T15707 T15706 arg1Of as,well
R10369 T15711 T15707 arg2Of models,as
R10370 T15711 T15708 arg1Of models,collagen-induced
R10371 T15711 T15709 arg1Of models,arthritis
R10372 T15711 T15710 arg1Of models,mouse
R10373 T15713 T15712 arg2Of 70,[
R10374 T15714 T15712 arg3Of ],[
R10375 T15717 T15716 arg2Of be,will
R10376 T15718 T15717 arg2Of interesting,be
R10377 T15720 T15719 arg1Of compare,to
R10378 T15720 T15735 arg1Of compare,or
R10379 T15722 T15720 arg2Of expression,compare
R10380 T15722 T15721 arg1Of expression,the
R10381 T15722 T15723 arg1Of expression,of
R10382 T15722 T15725 arg1Of expression,in
R10383 T15724 T15723 arg2Of SIGIRR,of
R10384 T15727 T15725 arg2Of patients,in
R10385 T15727 T15726 arg1Of patients,RA
R10386 T15727 T15728 arg1Of patients,with
R10387 T15730 T15728 arg2Of expression,with
R10388 T15730 T15729 arg1Of expression,its
R10389 T15730 T15731 arg1Of expression,in
R10390 T15733 T15731 arg2Of patients,in
R10391 T15733 T15732 arg1Of patients,control
R10392 T15735 T15715 arg1Of or,It
R10393 T15735 T15716 arg1Of or,will
R10394 T15735 T15717 arg1Of or,be
R10395 T15735 T15718 arg1Of or,interesting
R10396 T15735 T15734 arg1Of or,","
R10397 T15737 T15735 arg2Of investigate,or
R10398 T15737 T15736 arg1Of investigate,to
R10399 T15740 T15739 arg1Of function,the
R10400 T15740 T15741 arg1Of function,of
R10401 T15740 T15743 arg1Of function,is
R10402 T15740 T15744 arg2Of function,compromised
R10403 T15742 T15741 arg2Of SIGIRR,of
R10404 T15744 T15737 arg2Of compromised,investigate
R10405 T15744 T15738 arg1Of compromised,whether
R10406 T15744 T15743 arg2Of compromised,is
R10407 T15744 T15745 arg1Of compromised,in
R10408 T15747 T15745 arg2Of patients,in
R10409 T15747 T15746 arg1Of patients,RA
R10410 T15748 T15749 arg1Of Because,of
R10411 T15753 T15748 arg2Of pattern,Because
R10412 T15753 T15750 arg1Of pattern,its
R10413 T15753 T15751 arg1Of pattern,restricted
R10414 T15753 T15752 arg1Of pattern,expression
R10415 T15755 T15756 arg1Of SIGIRR,may
R10416 T15755 T15758 arg1Of SIGIRR,be
R10417 T15758 T15748 arg1Of be,Because
R10418 T15758 T15754 arg1Of be,","
R10419 T15758 T15756 arg2Of be,may
R10420 T15758 T15757 arg1Of be,also
R10421 T15762 T15758 arg2Of target,be
R10422 T15762 T15759 arg1Of target,an
R10423 T15762 T15760 arg1Of target,interesting
R10424 T15762 T15761 arg1Of target,therapeutic
R10425 T15762 T15763 arg1Of target,in
R10426 T15764 T15763 arg2Of RA,in
R10780 T16432 T16430 arg1Of factor,TNF
R10781 T16432 T16431 arg1Of factor,receptor-associated
R10782 T16432 T16433 arg1Of factor,1
R10783 T16434 T16435 arg1Of TRAF1,is
R10784 T16435 T16444 arg1Of is,because
R10785 T16438 T16435 arg2Of member,is
R10786 T16438 T16436 arg1Of member,a
R10787 T16438 T16437 arg1Of member,unique
R10788 T16438 T16439 arg1Of member,of
R10789 T16443 T16439 arg2Of family,of
R10790 T16443 T16440 arg1Of family,the
R10791 T16443 T16441 arg1Of family,TRAF
R10792 T16443 T16442 arg1Of family,protein
R10793 T16445 T16446 arg1Of it,lacks
R10794 T16445 T16453 arg1Of it,lacks
R10795 T16446 T16451 arg1Of lacks,and
R10796 T16450 T16446 arg2Of domain,lacks
R10797 T16450 T16447 arg1Of domain,a
R10798 T16450 T16448 arg1Of domain,RING
R10799 T16450 T16449 arg1Of domain,finger
R10800 T16451 T16444 arg2Of and,because
R10801 T16453 T16451 arg2Of lacks,and
R10802 T16453 T16452 arg1Of lacks,therefore
R10803 T16456 T16453 arg2Of activity,lacks
R10804 T16456 T16454 arg1Of activity,ubiquitin
R10805 T16456 T16455 arg1Of activity,ligase
R10806 T16458 T16457 arg1Of data,Accumulating
R10807 T16458 T16459 arg1Of data,support
R10808 T16459 T16480 arg1Of support,","
R10809 T16459 T16482 arg1Of support,in
R10810 T16459 T16486 arg1Of support,[
R10811 T16461 T16459 arg2Of role,support
R10812 T16461 T16460 arg1Of role,a
R10813 T16461 T16462 arg1Of role,for
R10814 T16461 T16464 arg1Of role,as
R10815 T16461 T16475 arg1Of role,by
R10816 T16463 T16462 arg2Of TRAF1,for
R10817 T16467 T16468 arg1Of negative,and
R10818 T16470 T16468 arg2Of positive,and
R10819 T16470 T16469 arg1Of positive,a
R10820 T16471 T16464 arg2Of modulator,as
R10821 T16471 T16465 arg1Of modulator,both
R10822 T16471 T16466 arg1Of modulator,a
R10823 T16471 T16467 arg1Of modulator,negative
R10824 T16471 T16470 arg1Of modulator,positive
R10825 T16471 T16472 arg1Of modulator,of
R10826 T16474 T16472 arg2Of signalling,of
R10827 T16474 T16473 arg1Of signalling,NF-κB
R10828 T16479 T16475 arg2Of receptors,by
R10829 T16479 T16476 arg1Of receptors,certain
R10830 T16479 T16477 arg1Of receptors,TNF
R10831 T16479 T16478 arg1Of receptors,family
R10832 T16482 T16481 arg1Of in,possibly
R10833 T16485 T16482 arg2Of manner,in
R10834 T16485 T16483 arg1Of manner,a
R10835 T16485 T16484 arg1Of manner,cell-type-dependent
R10836 T16487 T16486 arg2Of "71,72",[
R10837 T16488 T16486 arg3Of ],[
R10838 T16489 T16490 arg1Of Expression,of
R10839 T16489 T16492 arg1Of Expression,is
R10840 T16489 T16493 arg1Of Expression,inducible
R10841 T16491 T16490 arg2Of TRAF1,of
R10842 T16492 T16496 arg1Of is,and
R10843 T16493 T16492 arg2Of inducible,is
R10844 T16493 T16494 arg1Of inducible,by
R10845 T16495 T16494 arg2Of TNF,by
R10846 T16497 T16498 arg1Of overexpression,of
R10847 T16497 T16500 arg1Of overexpression,inhibits
R10848 T16499 T16498 arg2Of TRAF1,of
R10849 T16500 T16496 arg2Of inhibits,and
R10850 T16503 T16500 arg2Of activation,inhibits
R10851 T16503 T16501 arg1Of activation,TNF-induced
R10852 T16503 T16502 arg1Of activation,NF-κB
R10853 T16506 T16504 arg1Of cells,TRAF1-deficient
R10854 T16506 T16505 arg1Of cells,T
R10855 T16506 T16507 arg1Of cells,are
R10856 T16506 T16508 arg1Of cells,hyper-responsive
R10857 T16507 T16511 arg1Of are,","
R10858 T16507 T16512 arg1Of are,with
R10859 T16508 T16507 arg2Of hyper-responsive,are
R10860 T16508 T16509 arg1Of hyper-responsive,to
R10861 T16510 T16509 arg2Of TNF,to
R10862 T16514 T16515 arg1Of proliferation,and
R10863 T16515 T16512 arg2Of and,with
R10864 T16515 T16513 arg2Of and,enhanced
R10865 T16515 T16517 arg1Of and,of
R10866 T16516 T16515 arg2Of activation,and
R10867 T16521 T16517 arg2Of pathway,of
R10868 T16521 T16518 arg1Of pathway,the
R10869 T16521 T16519 arg1Of pathway,NF-κB
R10870 T16521 T16520 arg1Of pathway,signalling
R10871 T16522 T16524 arg1Of TRAF1,functions
R10872 T16524 T16523 arg1Of functions,also
R10873 T16524 T16525 arg1Of functions,as
R10874 T16528 T16525 arg2Of regulator,as
R10875 T16528 T16526 arg1Of regulator,a
R10876 T16528 T16527 arg1Of regulator,negative
R10877 T16528 T16529 arg1Of regulator,of
R10878 T16532 T16529 arg2Of activation,of
R10879 T16532 T16530 arg1Of activation,CD40-induced
R10880 T16532 T16531 arg1Of activation,NF-κB
R10881 T16535 T16533 arg1Of cells,TRAF1-deficient
R10882 T16535 T16534 arg1Of cells,dendritic
R10883 T16535 T16539 arg1Of cells,show
R10884 T16539 T16536 arg1Of show,","
R10885 T16539 T16537 arg1Of show,however
R10886 T16539 T16538 arg1Of show,","
R10887 T16539 T16548 arg1Of show,","
R10888 T16539 T16549 modOf show,suggesting
R10889 T16541 T16539 arg2Of responses,show
R10890 T16541 T16540 arg2Of responses,attenuated
R10891 T16541 T16542 arg1Of responses,to
R10892 T16544 T16542 arg2Of stimulation,to
R10893 T16544 T16543 arg1Of stimulation,secondary
R10894 T16544 T16545 arg1Of stimulation,by
R10895 T16547 T16545 arg2Of factors,by
R10896 T16547 T16546 arg1Of factors,TRAF2-dependent
R10897 T16549 T16554 arg1Of suggesting,in
R10898 T16553 T16549 arg2Of role,suggesting
R10899 T16553 T16550 arg1Of role,a
R10900 T16553 T16551 arg1Of role,positive
R10901 T16553 T16552 arg1Of role,regulatory
R10902 T16556 T16554 arg2Of cells,in
R10903 T16556 T16555 arg1Of cells,these
R10904 T16558 T16557 arg1Of mechanism,The
R10905 T16558 T16559 arg2Of mechanism,by
R10906 T16558 T16560 arg1Of mechanism,which
R10907 T16558 T16566 arg1Of mechanism,is
R10908 T16558 T16568 arg1Of mechanism,unclear
R10909 T16561 T16562 arg1Of TRAF1,modulates
R10910 T16562 T16559 arg1Of modulates,by
R10911 T16565 T16562 arg2Of activation,modulates
R10912 T16565 T16563 arg1Of activation,NF-
R10913 T16565 T16564 arg1Of activation,κB
R10914 T16566 T16567 arg1Of is,still
R10915 T16568 T16566 arg2Of unclear,is
R10916 T16570 T16569 arg1Of probably,Most
R10917 T16572 T16573 arg1Of TRAF1,competes
R10918 T16573 T16570 arg1Of competes,probably
R10919 T16573 T16571 arg1Of competes,","
R10920 T16573 T16574 arg1Of competes,with
R10921 T16577 T16574 arg2Of members,with
R10922 T16577 T16575 arg1Of members,TRAF
R10923 T16577 T16576 arg1Of members,family
R10924 T16577 T16578 arg1Of members,for
R10925 T16579 T16578 arg2Of binding,for
R10926 T16579 T16580 arg1Of binding,to
R10927 T16586 T16580 arg2Of proteins,to
R10928 T16586 T16581 arg1Of proteins,the
R10929 T16586 T16582 arg1Of proteins,receptor
R10930 T16586 T16583 arg1Of proteins,or
R10931 T16586 T16584 arg1Of proteins,other
R10932 T16586 T16585 arg1Of proteins,signalling
R10933 T16589 T16590 arg1Of TRAF1,might
R10934 T16589 T16591 arg1Of TRAF1,recruit
R10935 T16591 T16587 arg1Of recruit,Alternatively
R10936 T16591 T16588 arg1Of recruit,","
R10937 T16591 T16590 arg2Of recruit,might
R10938 T16592 T16591 arg2Of A20,recruit
R10939 T16592 T16593 arg2Of A20,with
R10940 T16592 T16594 arg1Of A20,which
R10941 T16595 T16596 arg1Of it,can
R10942 T16595 T16598 arg1Of it,interact
R10943 T16598 T16593 arg1Of interact,with
R10944 T16598 T16596 arg2Of interact,can
R10945 T16598 T16597 arg1Of interact,physically
R10946 T16598 T16599 arg1Of interact,[
R10947 T16600 T16599 arg2Of 73,[
R10948 T16601 T16599 arg3Of ],[
R10949 T16605 T16602 arg1Of study,A
R10950 T16605 T16603 arg1Of study,genome-wide
R10951 T16605 T16604 arg1Of study,association
R10952 T16605 T16606 arg1Of study,examining
R10953 T16605 T16620 arg1Of study,identified
R10954 T16606 T16611 arg1Of examining,among
R10955 T16607 T16608 arg1Of more,than
R10956 T16609 T16608 arg2Of "300,000",than
R10957 T16610 T16606 arg2Of SNPs,examining
R10958 T16610 T16607 arg1Of SNPs,more
R10959 T16613 T16612 arg1Of "1,500",approximately
R10960 T16616 T16613 arg1Of cases,"1,500"
R10961 T16616 T16614 arg1Of cases,autoantibody-positive
R10962 T16616 T16615 arg1Of cases,RA
R10963 T16616 T16617 arg1Of cases,and
R10964 T16617 T16611 arg2Of and,among
R10965 T16619 T16617 arg2Of controls,and
R10966 T16619 T16618 arg1Of controls,"1,800"
R10967 T16620 T16630 arg1Of identified,as
R10968 T16620 T16636 arg1Of identified,[
R10969 T16623 T16620 arg2Of variation,identified
R10970 T16623 T16621 arg1Of variation,a
R10971 T16623 T16622 arg1Of variation,genetic
R10972 T16623 T16624 arg1Of variation,at
R10973 T16629 T16624 arg2Of locus,at
R10974 T16629 T16625 arg1Of locus,the
R10975 T16629 T16626 arg1Of locus,TRAF1-complement
R10976 T16629 T16627 arg1Of locus,component
R10977 T16629 T16628 arg1Of locus,5
R10978 T16635 T16630 arg2Of locus,as
R10979 T16635 T16631 arg1Of locus,an
R10980 T16635 T16632 arg1Of locus,important
R10981 T16635 T16633 arg1Of locus,RA
R10982 T16635 T16634 arg1Of locus,risk
R10983 T16637 T16636 arg2Of 74,[
R10984 T16638 T16636 arg3Of ],[
R10985 T16640 T16639 arg1Of work,Subsequent
R10986 T16640 T16641 arg1Of work,indicates
R10987 T16643 T16644 arg1Of TRAF1,is
R10988 T16643 T16646 arg1Of TRAF1,likely
R10989 T16643 T16648 arg1Of TRAF1,be
R10990 T16644 T16641 arg2Of is,indicates
R10991 T16644 T16642 arg1Of is,that
R10992 T16644 T16652 arg1Of is,[
R10993 T16646 T16644 arg2Of likely,is
R10994 T16646 T16645 arg1Of likely,more
R10995 T16648 T16646 arg2Of be,likely
R10996 T16648 T16647 arg1Of be,to
R10997 T16651 T16648 arg2Of locus,be
R10998 T16651 T16649 arg1Of locus,the
R10999 T16651 T16650 arg1Of locus,causative
R11000 T16653 T16652 arg2Of 75,[
R11001 T16654 T16652 arg3Of ],[
R11002 T16656 T16655 arg1Of work,Recent
R11007 T16660 T16659 arg1Of population,Korean
R11008 T16662 T16661 arg1Of demonstrates,also
R11009 T16664 T16662 arg2Of association,demonstrates
R11010 T16664 T16663 arg1Of association,genetic
R11011 T16664 T16665 arg1Of association,of
R11012 T16668 T16665 arg2Of region,of
R11013 T16668 T16666 arg1Of region,the
R11014 T16668 T16667 arg1Of region,TRAF1
R11015 T16668 T16669 arg1Of region,with
R11016 T16670 T16669 arg2Of RA,with
R11017 T16670 T16671 arg1Of RA,[
R11018 T16672 T16671 arg2Of 76,[
R11019 T16673 T16671 arg3Of ],[
R11440 T17544 T17545 arg1Of miRNAs,are
R11441 T17544 T17553 arg1Of miRNAs,represent
R11442 T17545 T17552 arg1Of are,and
R11443 T17547 T17546 arg1Of discovered,recently
R11444 T17548 T17545 arg2Of regulators,are
R11445 T17548 T17547 arg1Of regulators,discovered
R11446 T17548 T17549 arg1Of regulators,of
R11447 T17551 T17549 arg2Of expression,of
R11448 T17551 T17550 arg1Of expression,gene
R11449 T17553 T17552 arg2Of represent,and
R11450 T17555 T17553 arg2Of class,represent
R11451 T17555 T17554 arg1Of class,a
R11452 T17555 T17556 arg1Of class,of
R11453 T17559 T17556 arg2Of molecules,of
R11454 T17559 T17557 arg1Of molecules,noncoding
R11455 T17559 T17558 arg1Of molecules,RNA
R11456 T17559 T17560 arg1Of molecules,essential
R11457 T17560 T17561 arg1Of essential,in
R11458 T17563 T17564 arg1Of cellular,and
R11459 T17565 T17564 arg2Of developmental,and
R11460 T17566 T17561 arg2Of processes,in
R11461 T17566 T17562 arg1Of processes,many
R11462 T17566 T17563 arg1Of processes,cellular
R11463 T17566 T17565 arg1Of processes,developmental
R11464 T17566 T17567 arg1Of processes,","
R11465 T17566 T17568 arg1Of processes,including
R11466 T17570 T17569 arg1Of responses,immune
R11467 T17570 T17571 arg1Of responses,and
R11468 T17571 T17568 arg2Of and,including
R11469 T17572 T17571 arg2Of inflammation,and
R11470 T17573 T17574 arg1Of They,bind
R11471 T17576 T17574 arg2Of 3'-UTR,bind
R11472 T17576 T17575 arg1Of 3'-UTR,the
R11473 T17576 T17577 arg1Of 3'-UTR,of
R11474 T17579 T17577 arg2Of mRNAs,of
R11475 T17579 T17578 arg1Of mRNAs,target
R11476 T17579 T17580 arg1Of mRNAs,leading
R11477 T17580 T17581 arg1Of leading,to
R11478 T17583 T17582 arg1Of repression,the
R11479 T17583 T17584 arg1Of repression,of
R11480 T17583 T17587 arg1Of repression,and
R11481 T17586 T17584 arg2Of expression,of
R11482 T17586 T17585 arg1Of expression,protein
R11483 T17587 T17581 arg2Of and,to
R11484 T17589 T17587 arg2Of promotion,and
R11485 T17589 T17588 arg1Of promotion,the
R11486 T17589 T17590 arg1Of promotion,of
R11487 T17593 T17590 arg2Of degradation,of
R11488 T17593 T17591 arg1Of degradation,target
R11489 T17593 T17592 arg1Of degradation,mRNA
R11490 T17593 T17594 arg1Of degradation,[
R11491 T17595 T17594 arg2Of 77,[
R11492 T17596 T17594 arg3Of ],[
R11493 T17597 T17598 arg1Of miR-146a/b,and
R11494 T17598 T17600 arg1Of and,are
R11495 T17598 T17601 arg1Of and,of
R11496 T17599 T17598 arg2Of miR-155,and
R11497 T17600 T17609 arg1Of are,","
R11498 T17600 T17610 arg1Of are,since
R11499 T17601 T17600 arg2Of of,are
R11500 T17603 T17601 arg2Of interest,of
R11501 T17603 T17602 arg1Of interest,particular
R11502 T17603 T17604 arg1Of interest,for
R11503 T17606 T17604 arg2Of signalling,for
R11504 T17606 T17605 arg1Of signalling,inflammatory
R11505 T17606 T17607 arg1Of signalling,to
R11506 T17608 T17607 arg2Of NF-κB,to
R11507 T17612 T17611 arg1Of miRNAs,these
R11508 T17612 T17613 arg1Of miRNAs,can
R11509 T17612 T17614 arg1Of miRNAs,be
R11510 T17612 T17615 arg2Of miRNAs,induced
R11511 T17615 T17610 arg2Of induced,since
R11512 T17615 T17613 arg2Of induced,can
R11513 T17615 T17614 arg2Of induced,be
R11514 T17618 T17615 arg1Of stimuli,induced
R11515 T17618 T17616 arg2Of stimuli,by
R11516 T17618 T17617 arg1Of stimuli,inflammatory
R11517 T17618 T17620 arg1Of stimuli,as
R11518 T17620 T17619 arg1Of as,such
R11519 T17621 T17622 arg1Of IL-1β,","
R11520 T17622 T17624 arg1Of ",",and
R11521 T17623 T17622 arg2Of TNF,","
R11522 T17624 T17620 arg2Of and,as
R11523 T17625 T17624 arg2Of TLRs,and
R11524 T17625 T17626 arg1Of TLRs,[
R11525 T17627 T17626 arg2Of "78,79",[
R11526 T17628 T17626 arg3Of ],[
R11527 T17630 T17629 arg2Of addition,In
R11528 T17632 T17633 arg1Of miR-146a,is
R11529 T17633 T17629 arg1Of is,In
R11530 T17633 T17631 arg1Of is,","
R11531 T17633 T17638 arg1Of is,and
R11532 T17636 T17633 arg2Of gene,is
R11533 T17636 T17634 arg1Of gene,an
R11534 T17636 T17635 arg1Of gene,NF-κB-dependent
R11535 T17638 T17637 arg1Of and,","
R11536 T17643 T17644 arg1Of IRAK1,and
R11537 T17644 T17639 arg1Of and,the
R11538 T17644 T17640 arg1Of and,NF-κB
R11539 T17644 T17641 arg1Of and,signalling
R11540 T17644 T17642 arg1Of and,molecules
R11541 T17644 T17646 arg1Of and,were
R11542 T17644 T17647 arg2Of and,identified
R11543 T17645 T17644 arg2Of TRAF6,and
R11544 T17647 T17638 arg2Of identified,and
R11545 T17647 T17646 arg2Of identified,were
R11546 T17647 T17648 arg1Of identified,as
R11547 T17647 T17653 arg1Of identified,[
R11548 T17647 T17656 arg1Of identified,(
R11549 T17650 T17648 arg2Of genes,as
R11550 T17650 T17649 arg1Of genes,target
R11551 T17650 T17651 arg1Of genes,of
R11552 T17652 T17651 arg2Of miR-146a,of
R11553 T17654 T17653 arg2Of 78,[
R11554 T17655 T17653 arg3Of ],[
R11555 T17657 T17656 arg2Of Figure,(
R11556 T17657 T17658 arg1Of Figure,1
R11557 T17659 T17656 arg3Of ),(
R11558 T17662 T17663 arg1Of miR-155,was
R11559 T17662 T17664 arg2Of miR-155,shown
R11560 T17664 T17660 arg1Of shown,Similarly
R11561 T17664 T17661 arg1Of shown,","
R11562 T17664 T17663 arg2Of shown,was
R11563 T17664 T17665 arg1Of shown,to
R11564 T17664 T17668 arg1Of shown,for
R11565 T17667 T17665 arg2Of transcripts,to
R11566 T17667 T17666 arg1Of transcripts,target
R11567 T17673 T17669 arg1Of IKKε,the
R11568 T17673 T17670 arg1Of IKKε,NF-κB
R11569 T17673 T17671 arg1Of IKKε,signalling
R11570 T17673 T17672 arg1Of IKKε,molecules
R11571 T17673 T17674 arg1Of IKKε,and
R11572 T17674 T17668 arg2Of and,for
R11573 T17675 T17674 arg2Of RIP1,and
R11574 T17675 T17676 arg1Of RIP1,[
R11575 T17677 T17676 arg2Of "79,80",[
R11576 T17678 T17676 arg3Of ],[
R11577 T17682 T17683 arg1Of miR-146,and
R11578 T17683 T17681 arg1Of and,both
R11579 T17683 T17685 arg1Of and,are
R11580 T17683 T17686 arg2Of and,expressed
R11581 T17684 T17683 arg2Of miR-155,and
R11582 T17686 T17685 arg2Of expressed,are
R11583 T17686 T17687 arg1Of expressed,at
R11584 T17686 T17704 arg1Of expressed,in
R11585 T17686 T17712 arg1Of expressed,[
R11586 T17687 T17703 arg1Of at,as
R11587 T17689 T17687 arg2Of levels,at
R11588 T17689 T17688 arg1Of levels,higher
R11589 T17689 T17690 arg1Of levels,in
R11590 T17693 T17691 arg1Of fibroblasts,RA
R11591 T17693 T17692 arg1Of fibroblasts,synovial
R11592 T17693 T17694 arg1Of fibroblasts,and
R11593 T17694 T17690 arg2Of and,in
R11594 T17696 T17694 arg2Of tissue,and
R11595 T17696 T17695 arg1Of tissue,synovial
R11596 T17696 T17697 arg1Of tissue,[
R11597 T17698 T17697 arg2Of "81,82",[
R11598 T17699 T17697 arg3Of ],[
R11599 T17703 T17700 arg1Of as,","
R11600 T17703 T17701 arg1Of as,as
R11601 T17703 T17702 arg1Of as,well
R11602 T17704 T17703 arg2Of in,as
R11603 T17708 T17704 arg2Of cells,in
R11604 T17708 T17705 arg1Of cells,peripheral
R11605 T17708 T17706 arg1Of cells,blood
R11606 T17708 T17707 arg1Of cells,mononuclear
R11607 T17708 T17709 arg1Of cells,of
R11608 T17711 T17709 arg2Of patients,of
R11609 T17711 T17710 arg1Of patients,RA
R11610 T17713 T17712 arg2Of 83,[
R11611 T17714 T17712 arg3Of ],[
R11612 T17715 T17716 arg1Of . miR-14,6a
R11613 T17715 T17718 arg2Of . miR-14,lso overexpre
R11614 T17718 T17679 arg1Of lso overexpre,Notably
R11615 T17718 T17680 arg1Of lso overexpre,","
R11616 T17718 T17685 modOf lso overexpre,are
R11617 T17718 T17716 arg2Of lso overexpre,6a
R11618 T17718 T17717 arg1Of lso overexpre,is a
R11619 T17718 T17719 arg1Of lso overexpre,ss
R11620 T17720 T17721 arg1Of ed i,n C
R11621 T17722 T17721 arg2Of D4+ and IL-17-p,n C
R11622 T17724 T17719 arg2Of oduci,ss
R11623 T17724 T17720 arg1Of oduci,ed i
R11624 T17724 T17722 arg1Of oduci,D4+ and IL-17-p
R11625 T17724 T17723 arg1Of oduci,r
R11626 T17724 T17725 arg1Of oduci,ng T
R11627 T17727 T17725 arg2Of lls from,ng T
R11628 T17727 T17726 arg1Of lls from,ce
R11629 T17727 T17728 arg1Of lls from,R
R11630 T17729 T17728 arg2Of A pat,R
R11631 T17730 T17728 arg3Of i,R
R11632 T17734 T17733 arg1Of polymorphism,a
R11633 T17734 T17735 arg1Of polymorphism,in
R11634 T17734 T17743 arg1Of polymorphism,was
R11635 T17734 T17745 arg2Of polymorphism,shown
R11636 T17734 T17747 arg1Of polymorphism,be
R11637 T17734 T17748 arg2Of polymorphism,associated
R11638 T17737 T17735 arg2Of 3'-UTR,in
R11639 T17737 T17736 arg1Of 3'-UTR,the
R11640 T17737 T17738 arg1Of 3'-UTR,of
R11641 T17742 T17738 arg2Of gene,of
R11642 T17742 T17739 arg1Of gene,the
R11643 T17742 T17740 arg1Of gene,miR-146a
R11644 T17742 T17741 arg1Of gene,target
R11645 T17745 T17731 arg1Of shown,Interestingly
R11646 T17745 T17732 arg1Of shown,","
R11647 T17745 T17743 arg2Of shown,was
R11648 T17745 T17744 arg1Of shown,recently
R11649 T17748 T17745 arg3Of associated,shown
R11650 T17748 T17746 arg1Of associated,to
R11651 T17748 T17747 arg2Of associated,be
R11652 T17748 T17749 arg1Of associated,with
R11653 T17748 T17757 arg1Of associated,io
R11654 T17753 T17752 arg2Of 86,[
R11655 T17754 T17752 arg3Of ],[
R11656 T17756 T17749 arg2Of 55 overexpress,with
R11657 T17756 T17750 arg1Of 55 overexpress,RA
R11658 T17756 T17751 arg1Of 55 overexpress,susceptibility
R11659 T17756 T17752 arg1Of 55 overexpress,[
R11660 T17756 T17755 arg1Of 55 overexpress,. miR-1
R11661 T17759 T17758 arg1Of ovial fibro,n in syn
R11662 T17759 T17760 arg1Of ovial fibro,bla
R11663 T17759 T17761 arg1Of ovial fibro,sts
R11664 T17759 T17763 arg1Of ovial fibro,s able
R11665 T17760 T17757 arg2Of bla,io
R11666 T17761 T17760 arg2Of sts ,bla
R11667 T17763 T17761 arg2Of s able ,sts
R11668 T17763 T17762 arg1Of s able ,wa
R11669 T17765 T17766 arg1Of pre,ven
R11670 T17767 T17766 arg2Of t the TLR and cyto,ven
R11671 T17768 T17763 arg2Of kine-induc,s able
R11672 T17768 T17764 arg1Of kine-induc,to
R11673 T17768 T17765 arg1Of kine-induc,pre
R11674 T17768 T17767 arg1Of kine-induc,t the TLR and cyto
R11675 T17768 T17769 arg1Of kine-induc,ib
R11676 T17772 T17769 arg2Of of specific matrix,ib
R11677 T17772 T17770 arg1Of of specific matrix,le expre
R11678 T17772 T17771 arg1Of of specific matrix,ssion
R11679 T17772 T17773 arg1Of of specific matrix,meta
R11680 T17772 T17774 arg1Of of specific matrix,lloprot
R11681 T17774 T17777 arg1Of lloprot,at
R11682 T17774 T17779 arg1Of lloprot,t
R11683 T17776 T17774 arg2Of s that medi,lloprot
R11684 T17776 T17775 arg1Of s that medi,einase
R11685 T17778 T17777 arg2Of e ,at
R11686 T17780 T17779 arg2Of is,t
R11687 T17781 T17779 arg3Of s,t
R11688 T17784 T17785 arg1Of miR-155,was
R11689 T17784 T17786 arg2Of miR-155,shown
R11690 T17784 T17788 arg1Of miR-155,promote
R11691 T17786 T17785 arg2Of shown,was
R11692 T17786 T17804 arg1Of shown,46
R11693 T17788 T17786 arg3Of promote,shown
R11694 T17788 T17787 arg1Of promote,to
R11695 T17788 T17795 arg1Of promote,in
R11696 T17790 T17788 arg2Of production,promote
R11697 T17790 T17789 arg1Of production,TNF
R11698 T17790 T17791 arg1Of production,","
R11699 T17794 T17791 arg2Of process,","
R11700 T17794 T17792 arg1Of process,a
R11701 T17794 T17793 arg1Of process,key
R11702 T17797 T17795 arg2Of pathogenesis,in
R11703 T17797 T17796 arg1Of pathogenesis,the
R11704 T17797 T17798 arg1Of pathogenesis,of
R11705 T17799 T17798 arg2Of RA,of
R11706 T17801 T17800 arg2Of 87,[
R11707 T17802 T17800 arg3Of ],[
R11708 T17803 T17795 arg3Of . miR-1,in
R11709 T17803 T17800 arg1Of . miR-1,[
R11710 T17804 T17816 arg1Of 46 ,mma
R11711 T17805 T17806 arg1Of and miR,-15
R11712 T17805 T17808 arg1Of and miR,re
R11713 T17808 T17804 arg2Of re,46
R11714 T17808 T17806 arg2Of re,-15
R11715 T17808 T17807 arg1Of re,5 may the
R11716 T17810 T17809 arg1Of mportant,fore be i
R11717 T17811 T17808 arg2Of negative r,re
R11718 T17811 T17810 arg1Of negative r,mportant
R11719 T17811 T17812 arg1Of negative r,eg
R11720 T17811 T17814 arg1Of negative r,nf
R11721 T17813 T17812 arg2Of ulators of i,eg
R11722 T17815 T17814 arg2Of la,nf
R11723 T17816 T17782 arg1Of mma,Moreover
R11724 T17816 T17783 arg1Of mma,","
R11725 T17818 T17817 arg1Of in RA and,tion
R11726 T17818 T17819 arg1Of in RA and,the
R11727 T17818 T17825 arg1Of in RA and,t
R11728 T17818 T17826 arg1Of in RA and,of new trea
R11729 T17821 T17819 arg2Of potential f,the
R11730 T17821 T17820 arg1Of potential f,ir
R11731 T17821 T17822 arg1Of potential f,or
R11732 T17824 T17822 arg2Of developmen,or
R11733 T17824 T17823 arg1Of developmen,the
R11734 T17825 T17816 arg2Of t ,mma
R11735 T17826 T17825 arg2Of of new trea,t
R11736 T17828 T17827 arg2Of addition,In
R11737 T17832 T17830 arg1Of expression,their
R11738 T17832 T17831 arg2Of expression,increased
R11739 T17832 T17833 arg1Of expression,in
R11740 T17832 T17836 arg1Of expression,is
R11741 T17832 T17838 arg1Of expression,useful
R11742 T17835 T17833 arg2Of patients,in
R11743 T17835 T17834 arg1Of patients,RA
R11744 T17836 T17851 arg1Of is,[
R11745 T17836 T17855 arg1Of is,but
R11746 T17838 T17836 arg2Of useful,is
R11747 T17838 T17837 arg1Of useful,potentially
R11748 T17838 T17839 arg1Of useful,as
R11749 T17841 T17839 arg2Of marker,as
R11750 T17841 T17840 arg1Of marker,a
R11751 T17841 T17842 arg1Of marker,for
R11752 T17844 T17843 arg1Of diagnosis,disease
R11753 T17844 T17845 arg1Of diagnosis,","
R11754 T17845 T17848 arg1Of ",",or
R11755 T17846 T17845 arg2Of progression,","
R11756 T17848 T17842 arg2Of or,for
R11757 T17848 T17847 arg1Of or,","
R11758 T17850 T17848 arg2Of efficacy,or
R11759 T17850 T17849 arg1Of efficacy,treatment
R11760 T17852 T17851 arg2Of 88,[
R11761 T17853 T17851 arg3Of ],[
R11762 T17855 T17827 arg1Of but,In
R11763 T17855 T17829 arg1Of but,","
R11764 T17855 T17854 arg1Of but,","
R11765 T17856 T17857 arg1Of this,will
R11766 T17856 T17858 arg1Of this,require
R11767 T17856 T17860 arg1Of this,using
R11768 T17858 T17855 arg2Of require,but
R11769 T17858 T17857 arg2Of require,will
R11770 T17858 T17860 modOf require,using
R11771 T17859 T17858 arg2Of confirmation,require
R11772 T17862 T17863 arg1Of large,and
R11773 T17864 T17863 arg2Of well-defined,and
R11774 T17865 T17860 arg2Of cohort,using
R11775 T17865 T17861 arg1Of cohort,a
R11776 T17865 T17862 arg1Of cohort,large
R11777 T17865 T17864 arg1Of cohort,well-defined
R11778 T17867 T17868 arg1Of miR-146,and
R11779 T17868 T17866 arg2Of and,Besides
R11780 T17869 T17868 arg2Of miR-155,and
R11781 T17872 T17871 arg1Of number,a
R11782 T17872 T17873 arg1Of number,of
R11783 T17872 T17876 arg1Of number,with
R11784 T17872 T17890 arg1Of number,were
R11785 T17872 T17892 arg2Of number,identified
R11786 T17875 T17873 arg2Of miRNAs,of
R11787 T17875 T17874 arg1Of miRNAs,other
R11788 T17879 T17876 arg2Of role,with
R11789 T17879 T17877 arg1Of role,a
R11790 T17879 T17878 arg1Of role,potential
R11791 T17879 T17880 arg1Of role,in
R11792 T17879 T17887 arg1Of role,in
R11793 T17882 T17880 arg2Of control,in
R11794 T17882 T17881 arg1Of control,the
R11795 T17882 T17883 arg1Of control,of
R11796 T17886 T17883 arg2Of responses,of
R11797 T17886 T17884 arg1Of responses,NF-κB-dependent
R11798 T17886 T17885 arg1Of responses,inflammatory
R11799 T17889 T17887 arg2Of pathology,in
R11800 T17889 T17888 arg1Of pathology,RA
R11801 T17892 T17866 arg1Of identified,Besides
R11802 T17892 T17870 arg1Of identified,","
R11803 T17892 T17890 arg2Of identified,were
R11804 T17892 T17891 arg1Of identified,recently
R11805 T17895 T17893 arg2Of context,In
R11806 T17895 T17894 arg1Of context,this
R11807 T17897 T17898 arg1Of miR-124a,-
R11808 T17897 T17910 arg1Of miR-124a,was
R11809 T17897 T17911 arg2Of miR-124a,shown
R11810 T17897 T17913 arg1Of miR-124a,be
R11811 T17897 T17914 arg2Of miR-124a,decreased
R11812 T17901 T17898 arg2Of regulator,-
R11813 T17901 T17899 arg1Of regulator,a
R11814 T17901 T17900 arg1Of regulator,key
R11815 T17901 T17902 arg1Of regulator,of
R11816 T17907 T17902 arg2Of protein,of
R11817 T17907 T17903 arg1Of protein,the
R11818 T17907 T17904 arg1Of protein,chemokine
R11819 T17907 T17905 arg1Of protein,monocyte
R11820 T17907 T17906 arg1Of protein,chemoattractant
R11821 T17907 T17908 arg1Of protein,1
R11822 T17909 T17898 arg3Of -,-
R11823 T17911 T17893 arg1Of shown,In
R11824 T17911 T17896 arg1Of shown,","
R11825 T17911 T17910 arg2Of shown,was
R11826 T17914 T17911 arg3Of decreased,shown
R11827 T17914 T17912 arg1Of decreased,to
R11828 T17914 T17913 arg2Of decreased,be
R11829 T17914 T17915 arg1Of decreased,in
R11830 T17916 T17915 arg2Of synoviocytes,in
R11831 T17916 T17917 arg1Of synoviocytes,from
R11832 T17919 T17917 arg2Of patients,from
R11833 T17919 T17918 arg1Of patients,RA
R11834 T17919 T17920 arg1Of patients,[
R11835 T17921 T17920 arg2Of 89,[
R11836 T17922 T17920 arg3Of ],[
R11837 T17926 T17925 arg1Of levels,elevated
R11838 T17926 T17927 arg1Of levels,of
R11839 T17926 T17929 arg1Of levels,-
R11840 T17926 T17930 arg1Of levels,leading
R11841 T17926 T17939 arg1Of levels,-
R11842 T17926 T17940 arg1Of levels,were
R11843 T17926 T17941 arg2Of levels,detected
R11844 T17928 T17927 arg2Of miR-203,of
R11845 T17930 T17931 arg1Of leading,to
R11846 T17933 T17931 arg2Of secretion,to
R11847 T17933 T17932 arg2Of secretion,increased
R11848 T17933 T17934 arg1Of secretion,of
R11849 T17936 T17935 arg1Of metalloproteinase-1,matrix
R11850 T17936 T17937 arg1Of metalloproteinase-1,and
R11851 T17937 T17934 arg2Of and,of
R11852 T17938 T17937 arg2Of IL-6,and
R11853 T17941 T17923 arg1Of detected,Similarly
R11854 T17941 T17924 arg1Of detected,","
R11855 T17941 T17940 arg2Of detected,were
R11856 T17941 T17942 arg1Of detected,in
R11857 T17941 T17946 arg1Of detected,[
R11858 T17945 T17942 arg2Of fibroblasts,in
R11859 T17945 T17943 arg1Of fibroblasts,RA
R11860 T17945 T17944 arg1Of fibroblasts,synovial
R11861 T17947 T17946 arg2Of 90,[
R11862 T17948 T17946 arg3Of ],[
R11863 T17951 T17952 arg1Of miR-16,","
R11864 T17952 T17955 arg1Of ",",and
R11865 T17953 T17952 arg2Of miR-132,","
R11866 T17955 T17954 arg1Of and,","
R11867 T17955 T17957 arg1Of and,were
R11868 T17955 T17959 arg2Of and,shown
R11869 T17955 T17961 arg1Of and,have
R11870 T17956 T17955 arg2Of miR-223,and
R11871 T17959 T17949 arg1Of shown,Finally
R11872 T17959 T17950 arg1Of shown,","
R11873 T17959 T17957 arg2Of shown,were
R11874 T17959 T17958 arg1Of shown,also
R11875 T17959 T17968 arg1Of shown,","
R11876 T17959 T17969 modOf shown,indicating
R11877 T17961 T17959 arg3Of have,shown
R11878 T17961 T17960 arg1Of have,to
R11879 T17964 T17961 arg2Of expression,have
R11880 T17964 T17962 arg1Of expression,an
R11881 T17964 T17963 arg2Of expression,altered
R11882 T17964 T17965 arg1Of expression,in
R11883 T17967 T17965 arg2Of patients,in
R11884 T17967 T17966 arg1Of patients,RA
R11885 T17971 T17969 arg2Of potential,indicating
R11886 T17971 T17970 arg1Of potential,their
R11887 T17971 T17972 arg1Of potential,as
R11888 T17974 T17972 arg2Of biomarkers,as
R11889 T17974 T17973 arg1Of biomarkers,diagnostic
R11890 T17974 T17975 arg1Of biomarkers,for
R11891 T17976 T17975 arg2Of pathogenesis,for
R11892 T17976 T17977 arg1Of pathogenesis,[
R11893 T17978 T17977 arg2Of "83,88,91",[
R11894 T17979 T17977 arg3Of ],[
R12465 T18905 T18903 arg1Of family,The
R12466 T18905 T18904 arg1Of family,NF-κB
R12467 T18905 T18906 arg1Of family,of
R12468 T18905 T18909 arg1Of family,plays
R12469 T18908 T18906 arg2Of factors,of
R12470 T18908 T18907 arg1Of factors,transcription
R12471 T18909 T18912 arg1Of plays,in
R12472 T18911 T18909 arg2Of roles,plays
R12473 T18911 T18910 arg1Of roles,crucial
R12474 T18915 T18912 arg2Of processes,in
R12475 T18915 T18913 arg1Of processes,the
R12476 T18915 T18914 arg1Of processes,inflammatory
R12477 T18915 T18916 arg1Of processes,in
R12478 T18915 T18918 arg1Of processes,leading
R12479 T18917 T18916 arg2Of RA,in
R12480 T18918 T18919 arg1Of leading,to
R12481 T18920 T18921 arg1Of cartilage,and
R12482 T18922 T18921 arg2Of bone,and
R12483 T18923 T18919 arg2Of destruction,to
R12484 T18923 T18920 arg1Of destruction,cartilage
R12485 T18923 T18922 arg1Of destruction,bone
R12486 T18926 T18924 arg1Of activation,Keeping
R12487 T18926 T18925 arg1Of activation,NF-κB
R12488 T18926 T18927 arg1Of activation,under
R12489 T18926 T18929 arg1Of activation,can
R12490 T18926 T18931 arg1Of activation,be
R12491 T18926 T18933 arg1Of activation,important
R12492 T18928 T18927 arg2Of control,under
R12493 T18931 T18929 arg2Of be,can
R12494 T18931 T18930 arg1Of be,thus
R12495 T18933 T18931 arg2Of important,be
R12496 T18933 T18932 arg1Of important,very
R12497 T18933 T18934 arg1Of important,for
R12498 T18936 T18934 arg2Of design,for
R12499 T18936 T18935 arg1Of design,the
R12500 T18936 T18937 arg1Of design,of
R12501 T18939 T18937 arg2Of therapeutics,of
R12502 T18939 T18938 arg1Of therapeutics,specific
R12503 T18941 T18940 arg1Of existence,The
R12504 T18941 T18942 arg1Of existence,of
R12505 T18941 T18957 arg1Of existence,raises
R12506 T18945 T18942 arg2Of regulators,of
R12507 T18945 T18943 arg1Of regulators,multiple
R12508 T18945 T18944 arg1Of regulators,negative
R12509 T18945 T18946 arg1Of regulators,ensuring
R12510 T18949 T18946 arg2Of regulation,ensuring
R12511 T18949 T18947 arg1Of regulation,a
R12512 T18949 T18948 arg1Of regulation,tight
R12513 T18949 T18950 arg1Of regulation,of
R12514 T18953 T18950 arg2Of pathway,of
R12515 T18953 T18951 arg1Of pathway,the
R12516 T18953 T18952 arg1Of pathway,NF-κB
R12517 T18957 T18954 arg1Of raises,","
R12518 T18957 T18955 arg1Of raises,however
R12519 T18957 T18956 arg1Of raises,","
R12520 T18959 T18958 arg1Of question,the
R12521 T18959 T18960 arg1Of question,of
R12522 T18959 T18969 arg1Of question,and
R12523 T18963 T18960 arg2Of role,of
R12524 T18963 T18961 arg1Of role,the
R12525 T18963 T18962 arg1Of role,specific
R12526 T18963 T18964 arg1Of role,of
R12527 T18965 T18964 arg2Of each,of
R12528 T18965 T18966 arg1Of each,of
R12529 T18968 T18966 arg2Of regulators,of
R12530 T18968 T18967 arg1Of regulators,these
R12531 T18969 T18957 arg2Of and,raises
R12532 T18971 T18969 arg2Of relationship,and
R12533 T18971 T18970 arg1Of relationship,the
R12534 T18971 T18972 arg1Of relationship,between
R12535 T18973 T18972 arg2Of them,between
R12536 T18975 T18974 arg2Of addition,In
R12547 T18987 T18989 arg2Of mRNAs,target
R12548 T18988 T18989 arg1Of they,target
R12549 T18992 T18991 arg1Of complexity,intense
R12550 T18992 T18993 arg1Of complexity,can
R12551 T18992 T18994 arg1Of complexity,be
R12552 T18992 T18995 arg2Of complexity,expected
R12553 T18995 T18974 arg1Of expected,In
R12554 T18995 T18976 arg1Of expected,","
R12555 T18995 T18977 arg1Of expected,given
R12556 T18995 T18990 arg1Of expected,","
R12557 T18995 T18993 arg2Of expected,can
R12558 T18995 T18994 arg2Of expected,be
R12559 T18996 T19004 arg1Of How,will
R12560 T18996 T19005 arg1Of How,be
R12561 T18996 T19012 arg1Of How,clarify
R12562 T19000 T18997 arg1Of signals,all
R12563 T19000 T18998 arg1Of signals,these
R12564 T19000 T18999 arg1Of signals,regulatory
R12565 T19000 T19001 arg1Of signals,are
R12566 T19001 T18996 arg1Of are,How
R12567 T19002 T19003 arg1Of themselves,regulated
R12568 T19005 T19003 arg2Of be,regulated
R12569 T19005 T19004 arg2Of be,will
R12570 T19005 T19009 arg1Of be,in
R12571 T19008 T19005 arg2Of question,be
R12572 T19008 T19006 arg1Of question,an
R12573 T19008 T19007 arg1Of question,important
R12574 T19010 T19009 arg2Of order,in
R12575 T19012 T19009 arg3Of clarify,in
R12576 T19012 T19011 arg1Of clarify,to
R12577 T19012 T19018 arg1Of clarify,","
R12578 T19012 T19019 arg1Of clarify,and
R12579 T19012 T19020 arg1Of clarify,","
R12580 T19012 T19022 arg1Of clarify,importantly
R12581 T19012 T19023 arg1Of clarify,","
R12582 T19013 T19012 arg2Of how,clarify
R12583 T19015 T19014 arg1Of signalling,NF-κB
R12584 T19015 T19016 arg1Of signalling,is
R12585 T19015 T19017 arg2Of signalling,organised
R12586 T19017 T19013 arg1Of organised,how
R12587 T19017 T19016 arg2Of organised,is
R12588 T19022 T19021 arg1Of importantly,more
R12589 T19024 T19012 arg3Of how,clarify
R12590 T19026 T19025 arg1Of knowledge,this
R12591 T19026 T19027 arg1Of knowledge,may
R12592 T19026 T19028 arg1Of knowledge,lead
R12593 T19028 T19024 arg1Of lead,how
R12594 T19028 T19027 arg2Of lead,may
R12595 T19028 T19029 arg1Of lead,to
R12596 T19031 T19029 arg2Of treatments,to
R12597 T19031 T19030 arg1Of treatments,new
R12598 T19031 T19032 arg1Of treatments,for
R12599 T19034 T19032 arg2Of diseases,for
R12600 T19034 T19033 arg1Of diseases,inflammatory
R12601 T19034 T19036 arg1Of diseases,as
R12602 T19036 T19035 arg1Of as,such
R12603 T19037 T19036 arg2Of RA,as
R12928 T19642 T19640 arg1Of signalling,Canonical
R12929 T19642 T19641 arg1Of signalling,NF-κB
R12930 T19642 T19643 arg1Of signalling,and
R12931 T19645 T19643 arg2Of regulators,and
R12932 T19645 T19644 arg1Of regulators,negative
R12933 T19647 T19646 arg1Of engagement,Ligand
R12934 T19647 T19648 arg1Of engagement,of
R12935 T19647 T19662 arg1Of engagement,trigger
R12936 T19651 T19648 arg2Of receptors,of
R12937 T19651 T19649 arg1Of receptors,specific
R12938 T19651 T19650 arg1Of receptors,membrane
R12939 T19651 T19653 arg1Of receptors,as
R12940 T19653 T19652 arg1Of as,such
R12941 T19654 T19655 arg1Of TNFR1,","
R12942 T19655 T19657 arg1Of ",",","
R12943 T19656 T19655 arg2Of CD40,","
R12944 T19657 T19660 arg1Of ",",and
R12945 T19658 T19657 arg2Of RANK,","
R12946 T19660 T19653 arg2Of and,as
R12947 T19660 T19659 arg1Of and,","
R12948 T19661 T19660 arg2Of TLR4,and
R12949 T19664 T19662 arg2Of recruitment,trigger
R12950 T19664 T19663 arg1Of recruitment,the
R12951 T19664 T19665 arg1Of recruitment,of
R12952 T19668 T19666 arg1Of proteins,specific
R12953 T19668 T19667 arg1Of proteins,adaptor
R12954 T19668 T19669 arg1Of proteins,(
R12955 T19668 T19692 arg1Of proteins,","
R12956 T19675 T19670 arg1Of protein,TNF
R12957 T19675 T19671 arg1Of protein,receptor
R12958 T19675 T19672 arg1Of protein,1-associated
R12959 T19675 T19673 arg1Of protein,death
R12960 T19675 T19674 arg1Of protein,domain
R12961 T19675 T19676 arg1Of protein,(
R12962 T19675 T19679 arg1Of protein,","
R12963 T19677 T19676 arg2Of TRADD,(
R12964 T19678 T19676 arg3Of ),(
R12965 T19679 T19681 arg1Of ",",","
R12966 T19680 T19679 arg2Of MyD88,","
R12967 T19681 T19683 arg1Of ",",","
R12968 T19682 T19681 arg2Of MAL,","
R12969 T19683 T19669 arg2Of ",",(
R12970 T19687 T19683 arg2Of IFNβ,","
R12971 T19687 T19684 arg1Of IFNβ,TIR
R12972 T19687 T19685 arg1Of IFNβ,domain-containing
R12973 T19687 T19686 arg1Of IFNβ,adaptor-inducing
R12974 T19687 T19688 arg1Of IFNβ,(
R12975 T19689 T19688 arg2Of TRIF,(
R12976 T19690 T19688 arg3Of ),(
R12977 T19691 T19669 arg3Of ),(
R12978 T19692 T19665 arg2Of ",",of
R12979 T19692 T19714 arg1Of ",",to
R12980 T19693 T19694 arg1Of kinases,(
R12981 T19693 T19702 arg1Of kinases,and
R12982 T19695 T19694 arg2Of RIP1,(
R12983 T19695 T19696 arg1Of RIP1,","
R12984 T19695 T19698 arg1Of RIP1,","
R12985 T19697 T19696 arg2Of IRAK1,","
R12986 T19699 T19698 arg2Of IRAK4,","
R12987 T19700 T19694 arg3Of ),(
R12988 T19702 T19692 arg2Of and,","
R12989 T19702 T19701 arg1Of and,","
R12990 T19704 T19702 arg2Of ligases,and
R12991 T19704 T19703 arg1Of ligases,ubiquitin
R12992 T19704 T19705 arg1Of ligases,(
R12993 T19706 T19707 arg1Of TRAF2,","
R12994 T19707 T19709 arg1Of ",",","
R12995 T19708 T19707 arg2Of TRAF6,","
R12996 T19709 T19705 arg2Of ",",(
R12997 T19709 T19711 arg1Of ",",","
R12998 T19710 T19709 arg2Of cIAP1,","
R12999 T19712 T19711 arg2Of cIAP2,","
R13000 T19713 T19705 arg3Of ),(
R13001 T19716 T19714 arg2Of receptor,to
R13002 T19716 T19715 arg1Of receptor,the
R13003 T19718 T19717 arg1Of polyubiquitination,K63-linked
R13004 T19718 T19719 arg1Of polyubiquitination,of
R13005 T19718 T19726 arg1Of polyubiquitination,is
R13006 T19718 T19727 arg2Of polyubiquitination,recognised
R13007 T19720 T19719 arg2Of TRAFs,of
R13008 T19720 T19721 arg1Of TRAFs,","
R13009 T19722 T19723 arg1Of RIP1,and
R13010 T19723 T19721 arg2Of and,","
R13011 T19724 T19723 arg2Of IRAK1,and
R13012 T19727 T19725 arg1Of recognised,","
R13013 T19727 T19726 arg2Of recognised,is
R13014 T19727 T19733 arg1Of recognised,","
R13015 T19727 T19734 modOf recognised,resulting
R13016 T19729 T19730 arg1Of NEMO,and
R13017 T19731 T19730 arg2Of TAB,and
R13018 T19732 T19727 arg1Of proteins,recognised
R13019 T19732 T19728 arg2Of proteins,by
R13020 T19732 T19729 arg1Of proteins,NEMO
R13021 T19732 T19731 arg1Of proteins,TAB
R13022 T19734 T19735 arg1Of resulting,in
R13023 T19737 T19738 arg1Of recruitment,and
R13024 T19738 T19735 arg2Of and,in
R13025 T19738 T19736 arg1Of and,the
R13026 T19738 T19740 arg1Of and,of
R13027 T19739 T19738 arg2Of activation,and
R13028 T19742 T19743 arg1Of IKK2,and
R13029 T19743 T19740 arg2Of and,of
R13030 T19743 T19741 arg1Of and,respectively
R13031 T19744 T19743 arg2Of TAK1,and
R13032 T19745 T19747 arg1Of TAK1,phosphorylates
R13033 T19745 T19749 arg1Of TAK1,activates
R13034 T19747 T19748 arg1Of phosphorylates,and
R13035 T19748 T19746 arg1Of and,then
R13036 T19749 T19748 arg2Of activates,and
R13037 T19750 T19747 arg2Of IKK2,phosphorylates
R13038 T19750 T19749 arg2Of IKK2,activates
R13039 T19750 T19751 arg1Of IKK2,","
R13040 T19750 T19752 arg1Of IKK2,which
R13041 T19750 T19755 arg1Of IKK2,phosphorylates
R13042 T19750 T19758 arg1Of IKK2,triggering
R13043 T19754 T19753 arg2Of turn,in
R13044 T19755 T19753 arg1Of phosphorylates,in
R13045 T19755 T19757 arg1Of phosphorylates,","
R13046 T19755 T19758 modOf phosphorylates,triggering
R13047 T19756 T19755 arg2Of IκBα,phosphorylates
R13048 T19761 T19760 arg1Of ubiquitination,K48-linked
R13049 T19761 T19762 arg1Of ubiquitination,and
R13050 T19762 T19758 arg2Of and,triggering
R13051 T19762 T19759 arg1Of and,its
R13052 T19764 T19762 arg2Of degradation,and
R13053 T19764 T19763 arg1Of degradation,proteasomal
R13054 T19765 T19766 arg1Of This,allows
R13055 T19767 T19766 arg2Of NF-κB,allows
R13056 T19767 T19768 arg1Of NF-κB,(
R13057 T19767 T19780 arg1Of NF-κB,translocate
R13058 T19767 T19785 arg1Of NF-κB,promote
R13059 T19770 T19768 arg2Of shown,(
R13060 T19770 T19769 arg1Of shown,here
R13061 T19770 T19771 arg1Of shown,as
R13062 T19773 T19771 arg2Of heterodimer,as
R13063 T19773 T19772 arg1Of heterodimer,a
R13064 T19773 T19774 arg1Of heterodimer,of
R13065 T19775 T19776 arg1Of p65,and
R13066 T19776 T19774 arg2Of and,of
R13067 T19777 T19776 arg2Of p50,and
R13068 T19778 T19768 arg3Of ),(
R13069 T19780 T19781 arg1Of translocate,to
R13070 T19780 T19784 arg1Of translocate,and
R13071 T19783 T19781 arg2Of nucleus,to
R13072 T19783 T19782 arg1Of nucleus,the
R13073 T19784 T19766 arg3Of and,allows
R13074 T19784 T19779 arg1Of and,to
R13075 T19785 T19784 arg2Of promote,and
R13076 T19788 T19785 arg2Of expression,promote
R13077 T19788 T19786 arg1Of expression,target
R13078 T19788 T19787 arg1Of expression,gene
R13079 T19789 T19790 arg1Of TRAF1,","
R13080 T19789 T19791 arg1Of TRAF1,which
R13081 T19789 T19792 arg1Of TRAF1,has
R13082 T19789 T19798 arg1Of TRAF1,can
R13083 T19789 T19800 arg1Of TRAF1,regulate
R13084 T19789 T19807 arg1Of TRAF1,competing
R13085 T19796 T19792 arg2Of activity,has
R13086 T19796 T19793 arg1Of activity,no
R13087 T19796 T19794 arg1Of activity,ubiquitin
R13088 T19796 T19795 arg1Of activity,ligase
R13089 T19800 T19797 arg1Of regulate,","
R13090 T19800 T19798 arg2Of regulate,can
R13091 T19800 T19799 arg1Of regulate,negatively
R13092 T19800 T19803 arg1Of regulate,","
R13093 T19800 T19806 arg1Of regulate,by
R13094 T19802 T19800 arg2Of activation,regulate
R13095 T19802 T19801 arg1Of activation,NF-κB
R13096 T19805 T19804 arg1Of probably,most
R13097 T19806 T19805 arg1Of by,probably
R13098 T19807 T19806 arg2Of competing,by
R13099 T19807 T19808 arg1Of competing,with
R13100 T19810 T19808 arg2Of TRAFs,with
R13101 T19810 T19809 arg1Of TRAFs,other
R13102 T19811 T19812 arg1Of A20,and
R13103 T19812 T19814 arg1Of and,are
R13104 T19812 T19815 arg1Of and,deubiquitinating
R13105 T19813 T19812 arg2Of CYLD,and
R13106 T19815 T19814 arg2Of deubiquitinating,are
R13107 T19816 T19815 arg2Of enzymes,deubiquitinating
R13108 T19816 T19817 arg1Of enzymes,that
R13109 T19816 T19818 arg1Of enzymes,control
R13110 T19816 T19822 arg1Of enzymes,targeting
R13111 T19818 T19821 arg1Of control,by
R13112 T19820 T19818 arg2Of activation,control
R13113 T19820 T19819 arg1Of activation,NF-κB
R13114 T19822 T19821 arg2Of targeting,by
R13115 T19825 T19822 arg2Of proteins,targeting
R13116 T19825 T19823 arg1Of proteins,specific
R13117 T19825 T19824 arg1Of proteins,signalling
R13118 T19825 T19826 arg1Of proteins,including
R13119 T19827 T19828 arg1Of RIP1,and
R13120 T19828 T19826 arg2Of and,including
R13121 T19828 T19830 arg1Of and,","
R13122 T19828 T19831 arg2Of and,to
R13123 T19828 T19832 arg1Of and,which
R13124 T19829 T19828 arg2Of TRAF6,and
R13125 T19833 T19834 arg1Of they,are
R13126 T19833 T19835 arg2Of they,recruited
R13127 T19835 T19834 arg2Of recruited,are
R13128 T19835 T19836 modOf recruited,using
R13129 T19835 T19844 arg1Of recruited,and
R13130 T19840 T19836 arg2Of proteins,using
R13131 T19840 T19837 arg1Of proteins,specific
R13132 T19840 T19838 arg1Of proteins,ubiquitin-binding
R13133 T19840 T19839 arg1Of proteins,adaptor
R13134 T19840 T19842 arg1Of proteins,as
R13135 T19842 T19841 arg1Of as,such
R13136 T19843 T19842 arg2Of ABIN-1,as
R13137 T19844 T19831 arg1Of and,to
R13138 T19846 T19845 arg1Of miR-146,p62.
R13139 T19846 T19847 arg1Of miR-146,is
R13140 T19846 T19848 arg2Of miR-146,thought
R13141 T19846 T19851 arg1Of miR-146,regulate
R13142 T19846 T19855 arg1Of miR-146,inhibiting
R13143 T19848 T19844 arg2Of thought,and
R13144 T19848 T19847 arg2Of thought,is
R13145 T19851 T19848 arg3Of regulate,thought
R13146 T19851 T19849 arg1Of regulate,to
R13147 T19851 T19850 arg1Of regulate,negatively
R13148 T19851 T19854 arg1Of regulate,by
R13149 T19853 T19851 arg2Of signalling,regulate
R13150 T19853 T19852 arg1Of signalling,TLR
R13151 T19855 T19854 arg2Of inhibiting,by
R13152 T19856 T19855 arg2Of expression,inhibiting
R13153 T19856 T19857 arg1Of expression,of
R13154 T19858 T19859 arg1Of IRAK1,and
R13155 T19859 T19857 arg2Of and,of
R13156 T19860 T19859 arg2Of TRAF6,and
R13157 T19864 T19863 arg1Of signalling,TLR
R13158 T19864 T19865 arg1Of signalling,can
R13159 T19864 T19867 arg1Of signalling,be
R13160 T19864 T19868 arg2Of signalling,inhibited
R13161 T19868 T19861 arg1Of inhibited,Finally
R13162 T19868 T19862 arg1Of inhibited,","
R13163 T19868 T19865 arg2Of inhibited,can
R13164 T19868 T19866 arg1Of inhibited,also
R13165 T19868 T19867 arg2Of inhibited,be
R13166 T19873 T19868 arg1Of SIGIRR,inhibited
R13167 T19873 T19869 arg2Of SIGIRR,by
R13168 T19873 T19870 arg1Of SIGIRR,the
R13169 T19873 T19871 arg1Of SIGIRR,transmembrane
R13170 T19873 T19872 arg1Of SIGIRR,protein
R13171 T19873 T19874 arg1Of SIGIRR,","
R13172 T19873 T19875 arg1Of SIGIRR,which
R13173 T19873 T19876 arg1Of SIGIRR,has
R13174 T19873 T19877 arg1Of SIGIRR,been
R13175 T19873 T19878 arg2Of SIGIRR,proposed
R13176 T19873 T19880 arg1Of SIGIRR,compete
R13177 T19878 T19876 arg2Of proposed,has
R13178 T19878 T19877 arg2Of proposed,been
R13179 T19880 T19878 arg3Of compete,proposed
R13180 T19880 T19879 arg1Of compete,to
R13181 T19880 T19881 arg1Of compete,with
R13182 T19882 T19881 arg2Of TLR4,with
R13183 T19882 T19883 arg1Of TLR4,for
R13184 T19884 T19883 arg2Of binding,for
R13185 T19884 T19885 arg1Of binding,to
R13186 T19886 T19887 arg1Of IRAK1,and
R13187 T19887 T19885 arg2Of and,to
R13188 T19888 T19887 arg2Of TRAF6,and
R13189 T19890 T19889 arg1Of expression,The
R13190 T19890 T19891 arg1Of expression,of
R13191 T19890 T19898 arg1Of expression,is
R13192 T19890 T19902 arg1Of expression,implicating
R13193 T19892 T19891 arg2Of many,of
R13194 T19892 T19893 arg1Of many,of
R13195 T19897 T19893 arg2Of molecules,of
R13196 T19897 T19894 arg1Of molecules,these
R13197 T19897 T19895 arg1Of molecules,negative
R13198 T19897 T19896 arg1Of molecules,regulatory
R13199 T19898 T19901 arg1Of is,","
R13200 T19898 T19902 modOf is,implicating
R13201 T19899 T19898 arg2Of NF-κB,is
R13202 T19899 T19900 arg1Of NF-κB,dependent
R13203 T19902 T19904 arg1Of implicating,in
R13204 T19903 T19902 arg2Of them,implicating
R13205 T19908 T19904 arg2Of regulation,in
R13206 T19908 T19905 arg1Of regulation,the
R13207 T19908 T19906 arg1Of regulation,negative
R13208 T19908 T19907 arg1Of regulation,feedback
R13209 T19908 T19909 arg1Of regulation,of
R13210 T19911 T19909 arg2Of activation,of
R13211 T19911 T19910 arg1Of activation,NF-κB
R13212 T19912 T19913 arg1Of ABIN,","
R13213 T19912 T19918 arg1Of ABIN,;
R13214 T19915 T19913 arg2Of inhibitor,","
R13215 T19915 T19914 arg1Of inhibitor,A20-binding
R13216 T19915 T19916 arg1Of inhibitor,of
R13217 T19917 T19916 arg2Of NF-κB,of
R13218 T19919 T19918 arg2Of cIAP,;
R13219 T19919 T19920 arg1Of cIAP,","
R13220 T19922 T19920 arg2Of inhibitor,","
R13221 T19922 T19921 arg1Of inhibitor,cellular
R13222 T19922 T19923 arg1Of inhibitor,of
R13223 T19924 T19923 arg2Of apoptosis,of
R13224 T19926 T19927 arg1Of CYLD,","
R13225 T19928 T19927 arg2Of cylindromatosis,","
R13226 T19930 T19929 arg2Of IKK,;
R13227 T19930 T19931 arg1Of IKK,","
R13228 T19930 T19934 arg1Of IKK,;
R13229 T19933 T19931 arg2Of kinase,","
R13230 T19933 T19932 arg1Of kinase,IκB
R13231 T19935 T19934 arg2Of IκB,;
R13232 T19935 T19936 arg1Of IκB,","
R13233 T19935 T19940 arg1Of IκB,;
R13234 T19937 T19936 arg2Of inhibitor,","
R13235 T19937 T19938 arg1Of inhibitor,of
R13236 T19939 T19938 arg2Of NF-κB,of
R13237 T19941 T19940 arg2Of IRAK,;
R13238 T19941 T19942 arg1Of IRAK,","
R13239 T19944 T19942 arg2Of kinase,","
R13242 T19952 T19947 arg2Of gene,","
R13243 T19952 T19948 arg1Of gene,myeloid
R13244 T19952 T19949 arg1Of gene,differentiation
R13245 T19952 T19950 arg1Of gene,primary
R13246 T19952 T19951 arg1Of gene,response
R13247 T19952 T19953 arg1Of gene,88
R13248 T19955 T19954 arg2Of NEMO,;
R13249 T19955 T19956 arg1Of NEMO,","
R13250 T19959 T19956 arg2Of modulator,","
R13251 T19959 T19957 arg1Of modulator,NF-κB
R13252 T19959 T19958 arg1Of modulator,essential
R13253 T19961 T19962 arg1Of NF,","
R13254 T19964 T19962 arg2Of factor,","
R13255 T19964 T19963 arg1Of factor,nuclear
R13256 T19966 T19967 arg1Of RANK,","
R13257 T19966 T19972 arg1Of RANK,;
R13258 T19969 T19967 arg2Of activator,","
R13259 T19969 T19968 arg1Of activator,receptor
R13260 T19969 T19970 arg1Of activator,of
R13261 T19971 T19970 arg2Of NF-κB,of
R13262 T19973 T19972 arg2Of RIP1,;
R13263 T19973 T19974 arg1Of RIP1,","
R13264 T19973 T19979 arg1Of RIP1,;
R13265 T19977 T19974 arg2Of protein,","
R13266 T19977 T19975 arg1Of protein,receptor
R13267 T19977 T19976 arg1Of protein,interacting
R13268 T19977 T19978 arg1Of protein,1
R13269 T19980 T19979 arg2Of SIGIRR,;
R13270 T19980 T19981 arg1Of SIGIRR,","
R13271 T19982 T19981 arg2Of single-immunoglobulinIL-1,","
R13272 T19982 T19983 arg1Of single-immunoglobulinIL-1,receptor-related
R13273 T19985 T19986 arg1Of TIR,","
R13274 T19985 T19989 arg1Of TIR,;
R13275 T19988 T19986 arg2Of receptor/IL-1R,","
R13276 T19988 T19987 arg1Of receptor/IL-1R,Toll-like
R13277 T19990 T19989 arg2Of TRAF,;
R13278 T19990 T19991 arg1Of TRAF,","
R13279 T19990 T19995 arg1Of TRAF,;
R13280 T19994 T19991 arg2Of factor,","
R13281 T19994 T19992 arg1Of factor,TNF
R13282 T19994 T19993 arg1Of factor,receptor-associated
R13283 T19996 T19995 arg2Of TLR,;
R13284 T19996 T19997 arg1Of TLR,","
R13285 T19996 T20000 arg1Of TLR,;
R13286 T19999 T19997 arg2Of receptor,","
R13287 T19999 T19998 arg1Of receptor,Toll-like
R13288 T20001 T20000 arg2Of TNF,;
R13289 T20001 T20002 arg1Of TNF,","
R13290 T20005 T20002 arg2Of factor,","
R13291 T20005 T20003 arg1Of factor,tumour
R13292 T20005 T20004 arg1Of factor,necrosis
R14009 T21534 T21532 arg1Of signalling,Noncanonical
R14010 T21534 T21533 arg1Of signalling,NF-κB
R14011 T21535 T21536 arg1Of CD40,and
R14012 T21536 T21538 arg1Of and,can
R14013 T21536 T21539 arg1Of and,activate
R14014 T21537 T21536 arg2Of RANK,and
R14015 T21539 T21538 arg2Of activate,can
R14016 T21543 T21539 arg2Of pathway,activate
R14017 T21543 T21540 arg1Of pathway,the
R14018 T21543 T21541 arg1Of pathway,noncanonical
R14019 T21543 T21542 arg1Of pathway,NF-κB
R14020 T21543 T21544 arg1Of pathway,that
R14021 T21543 T21545 arg1Of pathway,is
R14022 T21543 T21546 arg1Of pathway,dependent
R14023 T21546 T21545 arg2Of dependent,is
R14024 T21546 T21547 arg1Of dependent,on
R14025 T21548 T21547 arg2Of NF-κB,on
R14026 T21548 T21549 arg1Of NF-κB,inducing
R14027 T21552 T21551 arg2Of NIK,(
R14028 T21553 T21551 arg3Of ),(
R14029 T21555 T21549 arg2Of levels,inducing
R14030 T21555 T21550 arg1Of levels,kinase
R14031 T21555 T21551 arg1Of levels,(
R14032 T21555 T21554 arg1Of levels,expression
R14033 T21558 T21556 arg2Of cells,In
R14034 T21558 T21557 arg1Of cells,unstimulated
R14035 T21559 T21560 arg1Of NIK,forms
R14036 T21560 T21556 arg1Of forms,In
R14037 T21560 T21584 arg1Of forms,","
R14038 T21563 T21560 arg2Of complex,forms
R14039 T21563 T21561 arg1Of complex,a
R14040 T21563 T21562 arg1Of complex,cytosolic
R14041 T21563 T21564 arg1Of complex,with
R14042 T21567 T21565 arg1Of ligases,the
R14043 T21567 T21566 arg1Of ligases,ubiquitin
R14044 T21568 T21569 arg1Of TRAF2,","
R14045 T21569 T21571 arg1Of ",",and
R14046 T21570 T21569 arg2Of TRAF3,","
R14047 T21571 T21564 arg2Of and,with
R14048 T21571 T21567 arg1Of and,ligases
R14049 T21571 T21573 arg1Of and,","
R14050 T21571 T21574 arg1Of and,which
R14051 T21571 T21575 arg1Of and,facilitates
R14052 T21572 T21571 arg2Of cIAP1/2,and
R14053 T21577 T21578 arg1Of K48-linked,polyubiquitination
R14054 T21577 T21579 arg1Of K48-linked,and
R14055 T21580 T21579 arg2Of proteasomal,and
R14056 T21581 T21575 arg2Of degradation,facilitates
R14057 T21581 T21576 arg1Of degradation,the
R14058 T21581 T21577 arg1Of degradation,K48-linked
R14059 T21581 T21580 arg1Of degradation,proteasomal
R14060 T21581 T21582 arg1Of degradation,of
R14061 T21583 T21582 arg2Of NIK,of
R14062 T21585 T21560 arg3Of keeping,forms
R14063 T21587 T21585 arg2Of levels,keeping
R14064 T21587 T21586 arg1Of levels,NIK
R14065 T21587 T21588 arg1Of levels,low
R14066 T21588 T21585 arg3Of low,keeping
R14067 T21591 T21589 arg2Of binding,Upon
R14068 T21591 T21590 arg1Of binding,ligand
R14069 T21593 T21594 arg1Of TRAF3,is
R14070 T21593 T21595 arg2Of TRAF3,recruited
R14071 T21595 T21589 arg1Of recruited,Upon
R14072 T21595 T21592 arg1Of recruited,","
R14073 T21595 T21594 arg2Of recruited,is
R14074 T21595 T21596 arg1Of recruited,to
R14075 T21598 T21596 arg2Of receptor,to
R14076 T21598 T21597 arg1Of receptor,the
R14077 T21598 T21599 arg1Of receptor,","
R14078 T21598 T21600 arg1Of receptor,where
R14079 T21601 T21602 arg1Of TRAF2,directs
R14080 T21602 T21600 arg2Of directs,where
R14081 T21602 T21608 arg1Of directs,","
R14082 T21602 T21609 modOf directs,resulting
R14083 T21605 T21602 arg2Of polyubiquitination,directs
R14084 T21605 T21603 arg1Of polyubiquitination,nondegradative
R14085 T21605 T21604 arg1Of polyubiquitination,K63-linked
R14086 T21605 T21606 arg1Of polyubiquitination,of
R14087 T21607 T21606 arg2Of cIAP1/2,of
R14088 T21609 T21610 arg1Of resulting,in
R14089 T21612 T21610 arg2Of activation,in
R14090 T21612 T21611 arg1Of activation,their
R14091 T21614 T21613 arg1Of cIAP1/2,Subsequently
R14092 T21614 T21615 arg1Of cIAP1/2,directs
R14093 T21618 T21617 arg1Of polyubiquitination,K48-linked
R14094 T21618 T21619 arg1Of polyubiquitination,to
R14095 T21618 T21623 arg1Of polyubiquitination,than
R14096 T21620 T21619 arg2Of TRAF3,to
R14097 T21623 T21615 arg2Of than,directs
R14098 T21623 T21616 arg1Of than,its
R14099 T21623 T21621 arg1Of than,","
R14100 T21623 T21622 arg1Of than,rather
R14101 T21624 T21623 arg2Of NIK,than
R14102 T21627 T21625 arg2Of result,As
R14103 T21627 T21626 arg1Of result,a
R14104 T21629 T21630 arg1Of TRAF3,is
R14105 T21629 T21631 arg2Of TRAF3,degraded
R14106 T21631 T21630 arg2Of degraded,is
R14107 T21631 T21632 arg1Of degraded,and
R14108 T21632 T21625 arg1Of and,As
R14109 T21632 T21628 arg1Of and,","
R14110 T21632 T21636 arg1Of and,","
R14111 T21632 T21637 modOf and,resulting
R14112 T21633 T21634 arg1Of NIK,is
R14113 T21633 T21635 arg2Of NIK,stabilised
R14114 T21635 T21632 arg2Of stabilised,and
R14115 T21635 T21634 arg2Of stabilised,is
R14116 T21637 T21638 arg1Of resulting,in
R14117 T21641 T21638 arg2Of levels,in
R14118 T21641 T21639 arg2Of levels,increased
R14119 T21641 T21640 arg1Of levels,NIK
R14120 T21641 T21642 arg1Of levels,in
R14121 T21644 T21642 arg2Of cell,in
R14122 T21644 T21643 arg1Of cell,the
R14123 T21645 T21647 arg1Of NIK,phosphorylates
R14124 T21645 T21649 arg1Of NIK,activates
R14125 T21647 T21648 arg1Of phosphorylates,and
R14126 T21648 T21646 arg1Of and,then
R14127 T21649 T21648 arg2Of activates,and
R14128 T21650 T21647 arg2Of IKK1,phosphorylates
R14129 T21650 T21649 arg2Of IKK1,activates
R14130 T21650 T21651 arg1Of IKK1,","
R14131 T21650 T21652 arg1Of IKK1,which
R14132 T21650 T21653 arg1Of IKK1,mediates
R14133 T21656 T21653 arg2Of phosphorylation,mediates
R14134 T21656 T21654 arg1Of phosphorylation,NF-κB
R14135 T21656 T21655 arg1Of phosphorylation,p100
R14136 T21657 T21658 arg1Of This,is
R14137 T21657 T21659 arg2Of This,followed
R14138 T21659 T21658 arg2Of followed,is
R14139 T21661 T21662 arg1Of K48-linked,polyubiquitination
R14140 T21661 T21663 arg1Of K48-linked,and
R14141 T21665 T21663 arg2Of proteasomal,and
R14142 T21665 T21664 arg1Of proteasomal,partial
R14143 T21666 T21659 arg1Of degradation,followed
R14144 T21666 T21660 arg2Of degradation,by
R14145 T21666 T21661 arg1Of degradation,K48-linked
R14146 T21666 T21665 arg1Of degradation,proteasomal
R14147 T21666 T21667 arg1Of degradation,of
R14148 T21666 T21671 arg1Of degradation,","
R14149 T21666 T21672 arg1Of degradation,which
R14150 T21666 T21673 arg1Of degradation,forms
R14151 T21668 T21667 arg2Of p100,of
R14152 T21668 T21669 arg1Of p100,to
R14153 T21670 T21669 arg2Of p52,to
R14154 T21675 T21673 arg2Of heterodimer,forms
R14155 T21675 T21674 arg1Of heterodimer,a
R14156 T21675 T21676 arg1Of heterodimer,with
R14157 T21675 T21678 modOf heterodimer,to
R14158 T21677 T21676 arg2Of RelB,with
R14159 T21679 T21678 arg1Of activate,to
R14160 T21680 T21679 arg2Of transcription,activate
R14161 T21681 T21682 arg1Of Next,to
R14162 T21683 T21682 arg2Of TRAF3,to
R14163 T21685 T21686 arg1Of TRAF1,has
R14164 T21685 T21688 arg1Of TRAF1,been
R14165 T21685 T21689 arg2Of TRAF1,identified
R14166 T21689 T21681 arg1Of identified,Next
R14167 T21689 T21684 arg1Of identified,","
R14168 T21689 T21686 arg2Of identified,has
R14169 T21689 T21687 arg1Of identified,also
R14170 T21689 T21688 arg2Of identified,been
R14171 T21689 T21690 arg1Of identified,as
R14172 T21689 T21697 arg1Of identified,","
R14173 T21689 T21700 arg1Of identified,by
R14174 T21693 T21690 arg2Of regulator,as
R14178 T21696 T21694 arg2Of pathway,of
R14179 T21696 T21695 arg1Of pathway,this
R14180 T21699 T21698 arg1Of probably,most
R14181 T21700 T21699 arg1Of by,probably
R14182 T21701 T21700 arg2Of competing,by
R14183 T21701 T21702 arg1Of competing,with
R14184 T21701 T21718 arg1Of competing,;
R14185 T21707 T21702 arg2Of cIAP,with
R14186 T21707 T21703 arg1Of cIAP,other
R14187 T21707 T21704 arg1Of cIAP,TNF
R14188 T21707 T21705 arg1Of cIAP,receptor-associated
R14189 T21707 T21706 arg1Of cIAP,factors.
R14190 T21707 T21708 arg1Of cIAP,","
R14191 T21707 T21713 arg1Of cIAP,;
R14192 T21710 T21708 arg2Of inhibitor,","
R14193 T21710 T21709 arg1Of inhibitor,cellular
R14194 T21710 T21711 arg1Of inhibitor,of
R14195 T21712 T21711 arg2Of apoptosis,of
R14196 T21714 T21713 arg2Of IKK,;
R14197 T21714 T21715 arg1Of IKK,","
R14198 T21717 T21715 arg2Of kinase,","
R14199 T21717 T21716 arg1Of kinase,IκB
R14200 T21719 T21689 arg3Of NF,identified
R14201 T21719 T21720 arg1Of NF,","
R14202 T21719 T21723 arg1Of NF,;
R14203 T21722 T21720 arg2Of factor,","
R14204 T21722 T21721 arg1Of factor,nuclear
R14205 T21724 T21723 arg2Of RANK,;
R14206 T21724 T21725 arg1Of RANK,","
R14207 T21724 T21730 arg1Of RANK,;
R14208 T21727 T21725 arg2Of activator,","
R14209 T21727 T21726 arg1Of activator,receptor
R14210 T21727 T21728 arg1Of activator,of
R14211 T21729 T21728 arg2Of NF-κB,of
R14212 T21731 T21730 arg2Of TRAF,;
R14213 T21731 T21732 arg1Of TRAF,","
R14214 T21731 T21736 arg1Of TRAF,;
R14215 T21735 T21732 arg2Of factor,","
R14216 T21735 T21733 arg1Of factor,TNF
R14217 T21735 T21734 arg1Of factor,receptor-associated
R14218 T21737 T21736 arg2Of TNF,;
R14219 T21737 T21738 arg1Of TNF,","
R14220 T21741 T21738 arg2Of factor,","
R14221 T21741 T21739 arg1Of factor,tumour
R14222 T21741 T21740 arg1Of factor,necrosis
R233 T375 T374 arg1Of arthritis,Rheumatoid
R234 T375 T376 arg1Of arthritis,(
R235 T375 T379 arg1Of arthritis,is
R236 T375 T386 arg1Of arthritis,affecting
R237 T377 T376 arg2Of RA,(
R238 T378 T376 arg3Of ),(
R239 T379 T385 arg1Of is,","
R240 T379 T386 modOf is,affecting
R241 T382 T381 arg1Of common,most
R242 T384 T379 arg2Of arthritis,is
R12537 T18979 T18977 arg2Of number,given
R12538 T18979 T18978 arg1Of number,the
R12539 T18979 T18980 arg1Of number,of
R12540 T18979 T18982 arg1Of number,in
R12541 T18981 T18980 arg2Of miRNAs,of
R12542 T18983 T18984 arg1Of humans,and
R12543 T18984 T18982 arg2Of and,in
R12544 T18987 T18984 arg2Of mRNAs,and
R12545 T18987 T18985 arg1Of mRNAs,the
R12546 T18987 T18986 arg1Of mRNAs,multiple

UBERON-AE

Id Subject Object Predicate Lexical cue
T17435 31175-31180 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T17434 31610-31616 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T17433 31134-31140 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T15483 27521-27532 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensively
T12641 24168-24174 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T12640 23983-23988 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T9641 20980-20985 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T9640 21249-21255 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T9639 20526-20532 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T9638 19732-19742 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium
T9637 19721-19742 http://purl.obolibrary.org/obo/UBERON_0001277 denotes intestinal epithelium
T9636 19612-19633 http://purl.obolibrary.org/obo/UBERON_0001277 denotes intestinal epithelial
T9635 19490-19511 http://purl.obolibrary.org/obo/UBERON_0001277 denotes intestinal epithelial
T9634 19721-19731 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T9633 19612-19622 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T9632 19490-19500 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T4236 13004-13009 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organ
T1754 6775-6779 http://purl.obolibrary.org/obo/UBERON_3000101 denotes hyal
T1753 6507-6521 http://purl.obolibrary.org/obo/UBERON_0001090 denotes synovial fluid
T1752 6904-6910 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T1751 6172-6178 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T1750 5601-5608 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
T1749 5433-5440 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
T1748 5086-5091 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organ
T1747 3114-3121 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
T323 2195-2201 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T322 1343-1349 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T321 1054-1067 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system

GO-BP

Id Subject Object Predicate Lexical cue
T21763 15150-15158 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T21762 15150-15158 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T21761 15150-15158 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T21760 15150-15158 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T21759 15080-15098 http://purl.obolibrary.org/obo/GO_0051092 denotes activator of NF-κB
T21758 15028-15031 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T21757 15017-15026 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T21756 15017-15026 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T21755 14995-15003 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T21754 14816-14829 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T21753 14649-14664 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T21752 14740-14751 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T21751 14179-14190 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T21750 14579-14582 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T21749 14555-14558 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T21748 14513-14516 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T21747 14473-14476 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T21746 14207-14210 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T21745 14194-14197 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T21744 14028-14031 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T21743 13982-13985 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T21742 13868-13878 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T20034 10260-10269 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T20033 10260-10269 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T20032 10238-10246 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T20031 10316-10334 http://purl.obolibrary.org/obo/GO_0007252 denotes inhibitor of NF-κB
T20030 10212-10230 http://purl.obolibrary.org/obo/GO_0007252 denotes inhibitor of NF-κB
T20029 10316-10334 http://purl.obolibrary.org/obo/GO_0032088 denotes inhibitor of NF-κB
T20028 10212-10230 http://purl.obolibrary.org/obo/GO_0032088 denotes inhibitor of NF-κB
T20027 10162-10172 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T20026 9551-9575 http://purl.obolibrary.org/obo/GO_0004843 denotes deubiquitinating enzymes
T20025 10492-10510 http://purl.obolibrary.org/obo/GO_0051092 denotes activator of NF-κB
T20024 10176-10192 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T20023 9589-9605 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T20022 9471-9487 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T20021 9430-9445 http://purl.obolibrary.org/obo/GO_0016874 denotes ligase activity
T20020 9420-9445 http://purl.obolibrary.org/obo/GO_0034450 denotes ubiquitin ligase activity
T20019 9420-9445 http://purl.obolibrary.org/obo/GO_1904667 denotes ubiquitin ligase activity
T20018 9420-9445 http://purl.obolibrary.org/obo/GO_0061630 denotes ubiquitin ligase activity
T20017 9420-9445 http://purl.obolibrary.org/obo/GO_1904668 denotes ubiquitin ligase activity
T20016 9420-9445 http://purl.obolibrary.org/obo/GO_1990757 denotes ubiquitin ligase activity
T20015 9420-9445 http://purl.obolibrary.org/obo/GO_1904666 denotes ubiquitin ligase activity
T20014 9420-9445 http://purl.obolibrary.org/obo/GO_0050372 denotes ubiquitin ligase activity
T20013 9420-9445 http://purl.obolibrary.org/obo/GO_0004842 denotes ubiquitin ligase activity
T20012 9383-9398 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T20011 9258-9269 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T20010 8757-8762 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T20009 9891-9901 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T20008 9822-9832 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T20007 9628-9638 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T20006 8556-8566 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T20042 10708-10716 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T20041 10708-10716 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T20040 10708-10716 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T20039 10708-10716 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T20038 10617-10628 http://purl.obolibrary.org/obo/GO_0004896 denotes receptor/IL
T20037 10626-10631 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1R
T20036 10342-10347 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1R
T20035 10294-10297 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T19043 33514-33530 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signalling
T19042 33520-33530 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T19041 33427-33434 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T19040 33134-33144 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T19039 32972-32988 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T19038 32843-32856 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T17987 31812-31824 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T17986 30425-30437 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T17985 30404-30420 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T17984 31859-31870 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T17983 30369-30392 http://purl.obolibrary.org/obo/GO_0032502 denotes developmental processes
T17982 30356-30392 http://purl.obolibrary.org/obo/GO_0048869 denotes cellular and developmental processes
T17981 30356-30364 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T17980 30273-30288 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T18003 32531-32568 http://purl.obolibrary.org/obo/GO_1904465 denotes secretion of matrix metalloproteinase
T18002 32531-32568 http://purl.obolibrary.org/obo/GO_1990773 denotes secretion of matrix metalloproteinase
T18001 32531-32568 http://purl.obolibrary.org/obo/GO_1904466 denotes secretion of matrix metalloproteinase
T18000 32531-32568 http://purl.obolibrary.org/obo/GO_1904464 denotes secretion of matrix metalloproteinase
T17999 32531-32540 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T17998 32785-32797 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T17997 31717-31729 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T17996 31680-31694 http://purl.obolibrary.org/obo/GO_0032640 denotes TNF production
T17995 30979-30995 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signalling
T17994 30816-30832 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signalling
T17993 30985-30995 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T17992 30822-30832 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T17991 30642-30652 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T17990 30557-30568 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T17989 30552-30568 http://purl.obolibrary.org/obo/GO_0006402 denotes mRNA degradation
T17988 32242-32264 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T16690 29231-29249 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathway
T16689 29207-29241 http://purl.obolibrary.org/obo/GO_1901224 denotes activation of the NF-κB signalling
T16688 29544-29561 http://purl.obolibrary.org/obo/GO_0051092 denotes NF- κB activation
T16687 29312-29328 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T16686 29104-29120 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T16685 29672-29682 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T16684 29231-29241 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T16683 28921-28931 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T16682 28808-28823 http://purl.obolibrary.org/obo/GO_0016874 denotes ligase activity
T16681 28798-28823 http://purl.obolibrary.org/obo/GO_0034450 denotes ubiquitin ligase activity
T16680 28798-28823 http://purl.obolibrary.org/obo/GO_1904667 denotes ubiquitin ligase activity
T16679 28798-28823 http://purl.obolibrary.org/obo/GO_0061630 denotes ubiquitin ligase activity
T16678 28798-28823 http://purl.obolibrary.org/obo/GO_1904668 denotes ubiquitin ligase activity
T16677 28798-28823 http://purl.obolibrary.org/obo/GO_1990757 denotes ubiquitin ligase activity
T16676 28798-28823 http://purl.obolibrary.org/obo/GO_1904666 denotes ubiquitin ligase activity
T16675 28798-28823 http://purl.obolibrary.org/obo/GO_0050372 denotes ubiquitin ligase activity
T16674 28798-28823 http://purl.obolibrary.org/obo/GO_0004842 denotes ubiquitin ligase activity
T14593 27198-27208 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T14592 26876-26892 http://purl.obolibrary.org/obo/GO_0016579 denotes deubiquitination
T14591 26439-26465 http://purl.obolibrary.org/obo/GO_0030316 denotes osteoclast differentiation
T14590 25964-25980 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T14589 27154-27164 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T14588 26338-26348 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T14587 26186-26196 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T14586 26123-26133 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T14585 25777-25787 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T14584 25644-25654 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T14583 25588-25611 http://purl.obolibrary.org/obo/GO_0004843 denotes deubiquitinating enzyme
T14582 25518-25533 http://purl.obolibrary.org/obo/GO_0007283 denotes spermatogenesis
T14581 25494-25516 http://purl.obolibrary.org/obo/GO_0051726 denotes cell cycle progression
T14580 25494-25516 http://purl.obolibrary.org/obo/GO_0007050 denotes cell cycle progression
T14579 25494-25504 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T14578 25478-25490 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T13131 24308-24320 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T13130 24289-24299 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T13129 24283-24299 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signalling
T13128 24269-24299 http://purl.obolibrary.org/obo/GO_1901222 denotes regulation of NF-κB signalling
T13127 23989-23998 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T13126 23895-23904 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T13125 23989-23998 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T13124 23895-23904 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T13123 24269-24279 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T13122 23425-23435 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T13121 23439-23455 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T13120 23060-23076 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T13119 23052-23076 http://purl.obolibrary.org/obo/GO_1903721 denotes inhibit NF-κB activation
T13118 23052-23065 http://purl.obolibrary.org/obo/GO_0007252 denotes inhibit NF-κB
T13117 22878-22897 http://purl.obolibrary.org/obo/GO_0007252 denotes inhibitors of NF-κB
T13116 23052-23065 http://purl.obolibrary.org/obo/GO_0032088 denotes inhibit NF-κB
T13115 22878-22897 http://purl.obolibrary.org/obo/GO_0032088 denotes inhibitors of NF-κB
T10682 22559-22572 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T10681 21671-21682 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T10680 20914-20923 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T10679 20654-20664 http://purl.obolibrary.org/obo/GO_0042056 denotes attractant
T10678 20197-20207 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T10677 19586-19602 http://purl.obolibrary.org/obo/GO_0002524 denotes hypersensitivity
T10676 19612-19639 http://purl.obolibrary.org/obo/GO_0060576 denotes intestinal epithelial cells
T10675 19490-19517 http://purl.obolibrary.org/obo/GO_0060576 denotes intestinal epithelial cells
T10674 19612-19639 http://purl.obolibrary.org/obo/GO_0060575 denotes intestinal epithelial cells
T10673 19490-19517 http://purl.obolibrary.org/obo/GO_0060575 denotes intestinal epithelial cells
T10672 19612-19639 http://purl.obolibrary.org/obo/GO_0060574 denotes intestinal epithelial cells
T10671 19490-19517 http://purl.obolibrary.org/obo/GO_0060574 denotes intestinal epithelial cells
T10670 19612-19639 http://purl.obolibrary.org/obo/GO_0061582 denotes intestinal epithelial cells
T10669 19490-19517 http://purl.obolibrary.org/obo/GO_0061582 denotes intestinal epithelial cells
T10668 20342-20354 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T10667 19178-19190 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T10666 19655-19664 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T10665 19373-19382 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T10664 18998-19007 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T10663 19655-19664 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T10662 19373-19382 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T10661 18998-19007 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T10660 20793-20809 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T10659 18946-18962 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T10658 18589-18591 http://purl.obolibrary.org/obo/GO_0061667 denotes E3
T10657 18589-18591 http://purl.obolibrary.org/obo/GO_0061666 denotes E3
T10656 18589-18591 http://purl.obolibrary.org/obo/GO_0061665 denotes E3
T10655 18589-18591 http://purl.obolibrary.org/obo/GO_0061664 denotes E3
T10654 18589-18591 http://purl.obolibrary.org/obo/GO_0061663 denotes E3
T10653 18589-18591 http://purl.obolibrary.org/obo/GO_0061662 denotes E3
T10652 18589-18591 http://purl.obolibrary.org/obo/GO_0061661 denotes E3
T10651 18589-18591 http://purl.obolibrary.org/obo/GO_0061660 denotes E3
T10650 18589-18591 http://purl.obolibrary.org/obo/GO_0061659 denotes E3
T10649 18589-18591 http://purl.obolibrary.org/obo/GO_0061630 denotes E3
T10648 18533-18535 http://purl.obolibrary.org/obo/GO_0061658 denotes E2
T10647 18533-18535 http://purl.obolibrary.org/obo/GO_0061657 denotes E2
T10646 18533-18535 http://purl.obolibrary.org/obo/GO_0061656 denotes E2
T10645 18533-18535 http://purl.obolibrary.org/obo/GO_0061655 denotes E2
T10644 18533-18535 http://purl.obolibrary.org/obo/GO_0061654 denotes E2
T10643 18533-18535 http://purl.obolibrary.org/obo/GO_0061653 denotes E2
T10642 18533-18535 http://purl.obolibrary.org/obo/GO_0061652 denotes E2
T10641 18533-18535 http://purl.obolibrary.org/obo/GO_0061651 denotes E2
T10640 18533-18535 http://purl.obolibrary.org/obo/GO_0061650 denotes E2
T10639 18533-18535 http://purl.obolibrary.org/obo/GO_0061631 denotes E2
T10638 18589-18591 http://purl.obolibrary.org/obo/GO_0019787 denotes E3
T10637 18533-18535 http://purl.obolibrary.org/obo/GO_0019787 denotes E2
T10636 18589-18591 http://purl.obolibrary.org/obo/GO_0004842 denotes E3
T10635 18533-18535 http://purl.obolibrary.org/obo/GO_0004842 denotes E2
T10634 22163-22170 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T10633 20217-20227 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T10632 19086-19096 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T10631 18717-18727 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T10630 18352-18362 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T10629 20211-20227 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signalling
T10628 18711-18727 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signalling
T10627 18346-18362 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signalling
T10626 18850-18868 http://purl.obolibrary.org/obo/GO_0007252 denotes inhibitor of NF-κB
T10625 18294-18307 http://purl.obolibrary.org/obo/GO_0007252 denotes inhibit NF-κB
T10624 18850-18868 http://purl.obolibrary.org/obo/GO_0032088 denotes inhibitor of NF-κB
T10623 18294-18307 http://purl.obolibrary.org/obo/GO_0032088 denotes inhibit NF-κB
T10622 20831-20846 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T10621 18054-18069 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T8748 16053-16069 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signalling
T8747 17705-17715 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T8746 17218-17228 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T8745 16833-16843 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T8744 16035-16045 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T8743 16007-16025 http://purl.obolibrary.org/obo/GO_0009987 denotes cellular processes
T8742 16007-16015 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T8757 17680-17683 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T8756 17462-17473 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T8755 16287-16299 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T8754 16147-16168 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T8753 16059-16077 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathway
T8752 17566-17576 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T8751 16446-16456 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T8750 16059-16069 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T8749 16440-16456 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signalling
T5606 15780-15795 http://purl.obolibrary.org/obo/GO_0032675 denotes IL-6 production
T5605 15780-15795 http://purl.obolibrary.org/obo/GO_0032635 denotes IL-6 production
T5604 15761-15764 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T5603 15469-15480 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T5602 15278-15307 http://purl.obolibrary.org/obo/GO_1901222 denotes noncanonical NF-κB signalling
T5601 15278-15307 http://purl.obolibrary.org/obo/GO_1901223 denotes noncanonical NF-κB signalling
T5600 13777-13780 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T5599 13725-13728 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T5598 13426-13429 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T5597 13330-13333 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T5596 13185-13188 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T5595 13179-13182 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T5594 13004-13021 http://purl.obolibrary.org/obo/GO_0048513 denotes organ development
T5593 13010-13021 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T5592 12972-12983 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T5591 12967-12983 http://purl.obolibrary.org/obo/GO_0048468 denotes cell development
T5590 12965-12983 http://purl.obolibrary.org/obo/GO_0002329 denotes B-cell development
T5589 12965-12983 http://purl.obolibrary.org/obo/GO_0002328 denotes B-cell development
T5588 12385-12390 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1R
T5587 12065-12078 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1 receptor
T5586 15278-15307 http://purl.obolibrary.org/obo/GO_1901224 denotes noncanonical NF-κB signalling
T5585 11684-11710 http://purl.obolibrary.org/obo/GO_1901224 denotes activated NF-κB signalling
T5584 11586-11588 http://purl.obolibrary.org/obo/GO_0061658 denotes E2
T5583 11586-11588 http://purl.obolibrary.org/obo/GO_0061657 denotes E2
T5582 11586-11588 http://purl.obolibrary.org/obo/GO_0061656 denotes E2
T5581 11586-11588 http://purl.obolibrary.org/obo/GO_0061655 denotes E2
T5580 11586-11588 http://purl.obolibrary.org/obo/GO_0061654 denotes E2
T5579 11586-11588 http://purl.obolibrary.org/obo/GO_0061653 denotes E2
T5578 11586-11588 http://purl.obolibrary.org/obo/GO_0061652 denotes E2
T5577 11586-11588 http://purl.obolibrary.org/obo/GO_0061651 denotes E2
T5576 11586-11588 http://purl.obolibrary.org/obo/GO_0061650 denotes E2
T5575 11586-11588 http://purl.obolibrary.org/obo/GO_0061631 denotes E2
T5574 11859-11872 http://purl.obolibrary.org/obo/GO_0000209 denotes polyubiquitin
T5573 11776-11789 http://purl.obolibrary.org/obo/GO_0000209 denotes polyubiquitin
T5572 11638-11651 http://purl.obolibrary.org/obo/GO_0000209 denotes polyubiquitin
T5571 11381-11394 http://purl.obolibrary.org/obo/GO_0000209 denotes polyubiquitin
T5570 11242-11255 http://purl.obolibrary.org/obo/GO_0000209 denotes polyubiquitin
T5569 11123-11132 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T5568 11123-11132 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T5567 11101-11109 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T5566 11589-11591 http://purl.obolibrary.org/obo/GO_0061667 denotes E3
T5565 11080-11082 http://purl.obolibrary.org/obo/GO_0061667 denotes E3
T5564 10985-10987 http://purl.obolibrary.org/obo/GO_0061667 denotes E3
T5563 11589-11591 http://purl.obolibrary.org/obo/GO_0061666 denotes E3
T5562 11080-11082 http://purl.obolibrary.org/obo/GO_0061666 denotes E3
T5561 10985-10987 http://purl.obolibrary.org/obo/GO_0061666 denotes E3
T5560 11589-11591 http://purl.obolibrary.org/obo/GO_0061665 denotes E3
T5559 11080-11082 http://purl.obolibrary.org/obo/GO_0061665 denotes E3
T5558 10985-10987 http://purl.obolibrary.org/obo/GO_0061665 denotes E3
T5557 11589-11591 http://purl.obolibrary.org/obo/GO_0061664 denotes E3
T5556 11080-11082 http://purl.obolibrary.org/obo/GO_0061664 denotes E3
T5555 10985-10987 http://purl.obolibrary.org/obo/GO_0061664 denotes E3
T5554 11589-11591 http://purl.obolibrary.org/obo/GO_0061663 denotes E3
T5553 11080-11082 http://purl.obolibrary.org/obo/GO_0061663 denotes E3
T5552 10985-10987 http://purl.obolibrary.org/obo/GO_0061663 denotes E3
T5551 11589-11591 http://purl.obolibrary.org/obo/GO_0061662 denotes E3
T5550 11080-11082 http://purl.obolibrary.org/obo/GO_0061662 denotes E3
T5549 10985-10987 http://purl.obolibrary.org/obo/GO_0061662 denotes E3
T5548 11589-11591 http://purl.obolibrary.org/obo/GO_0061661 denotes E3
T5547 11080-11082 http://purl.obolibrary.org/obo/GO_0061661 denotes E3
T5546 10985-10987 http://purl.obolibrary.org/obo/GO_0061661 denotes E3
T5545 11589-11591 http://purl.obolibrary.org/obo/GO_0061660 denotes E3
T5544 11080-11082 http://purl.obolibrary.org/obo/GO_0061660 denotes E3
T5543 10985-10987 http://purl.obolibrary.org/obo/GO_0061660 denotes E3
T5542 11589-11591 http://purl.obolibrary.org/obo/GO_0061659 denotes E3
T5541 11080-11082 http://purl.obolibrary.org/obo/GO_0061659 denotes E3
T5540 10985-10987 http://purl.obolibrary.org/obo/GO_0061659 denotes E3
T5539 11589-11591 http://purl.obolibrary.org/obo/GO_0061630 denotes E3
T5538 11080-11082 http://purl.obolibrary.org/obo/GO_0061630 denotes E3
T5537 10985-10987 http://purl.obolibrary.org/obo/GO_0061630 denotes E3
T5536 11586-11588 http://purl.obolibrary.org/obo/GO_0019787 denotes E2
T5535 11080-11082 http://purl.obolibrary.org/obo/GO_0019787 denotes E3
T5534 10985-10987 http://purl.obolibrary.org/obo/GO_0019787 denotes E3
T5533 11586-11588 http://purl.obolibrary.org/obo/GO_0004842 denotes E2
T5532 11080-11082 http://purl.obolibrary.org/obo/GO_0004842 denotes E3
T5531 10985-10987 http://purl.obolibrary.org/obo/GO_0004842 denotes E3
T5530 10867-10872 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T5529 15825-15844 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T5528 11684-11699 http://purl.obolibrary.org/obo/GO_0051092 denotes activated NF-κB
T5527 8507-8523 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T5526 13457-13486 http://purl.obolibrary.org/obo/GO_1903009 denotes degradation by the proteasome
T5525 8180-8209 http://purl.obolibrary.org/obo/GO_1903009 denotes degradation by the proteasome
T5524 13751-13762 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T5523 13678-13689 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T5522 13457-13468 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T5521 8180-8191 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T5520 13803-13818 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T5519 13137-13152 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T5518 8092-8107 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T5517 12606-12609 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T5516 11459-11462 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T5515 8220-8223 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T5514 8063-8066 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T5513 7917-7926 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T5512 15297-15316 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathways
T5511 10755-10774 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathways
T5510 7542-7561 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathways
T5509 15895-15905 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T5508 15297-15307 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T5507 11933-11943 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T5506 11700-11710 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T5505 10755-10765 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T5504 7860-7870 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T5503 7542-7552 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T5502 15278-15307 http://purl.obolibrary.org/obo/GO_0038061 denotes noncanonical NF-κB signalling
T5501 11694-11710 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signalling
T5500 10749-10765 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signalling
T5499 7854-7870 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signalling
T5498 7536-7552 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signalling
T5497 7405-7420 http://purl.obolibrary.org/obo/GO_2000144 denotes transactivation
T5496 7344-7363 http://purl.obolibrary.org/obo/GO_0007252 denotes inhibitors of NF-κB
T5495 7130-7148 http://purl.obolibrary.org/obo/GO_0007252 denotes inhibitor of NF-κB
T5494 7344-7363 http://purl.obolibrary.org/obo/GO_0032088 denotes inhibitors of NF-κB
T5493 7130-7148 http://purl.obolibrary.org/obo/GO_0032088 denotes inhibitor of NF-κB
T5492 7043-7054 http://purl.obolibrary.org/obo/GO_0051235 denotes sequestered
T5491 7030-7071 http://purl.obolibrary.org/obo/GO_0051220 denotes proteins are sequestered in the cytoplasm
T5490 7030-7054 http://purl.obolibrary.org/obo/GO_0050821 denotes proteins are sequestered
T5489 7030-7054 http://purl.obolibrary.org/obo/GO_0045185 denotes proteins are sequestered
T2513 6963-6978 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T2512 5851-5863 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T2511 5092-5101 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T2510 4812-4827 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activating
T2509 4810-4827 http://purl.obolibrary.org/obo/GO_0042113 denotes B-cell activating
T2508 4810-4827 http://purl.obolibrary.org/obo/GO_0050864 denotes B-cell activating
T2507 4384-4393 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T2506 4355-4379 http://purl.obolibrary.org/obo/GO_0048144 denotes fibroblast proliferation
T2505 5770-5780 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T2504 5034-5044 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T2503 3800-3810 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T2502 3794-3810 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signalling
T2501 6929-6945 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T2500 4325-4341 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T2499 3644-3660 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T2498 3532-3548 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T2497 3484-3503 http://purl.obolibrary.org/obo/GO_0051092 denotes activators of NF-κB
T2496 3235-3249 http://purl.obolibrary.org/obo/GO_0051092 denotes activate NF-κB
T2495 6586-6598 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T2494 5812-5824 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T2493 5531-5543 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T2492 5296-5308 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T2491 5122-5134 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T798 3032-3044 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T797 2918-2928 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T796 2912-2928 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signalling
T795 2713-2723 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T794 1942-1963 http://purl.obolibrary.org/obo/GO_0051001 denotes nitric oxide synthase
T793 1942-1963 http://purl.obolibrary.org/obo/GO_0050999 denotes nitric oxide synthase
T792 1942-1963 http://purl.obolibrary.org/obo/GO_0051000 denotes nitric oxide synthase
T791 1942-1963 http://purl.obolibrary.org/obo/GO_0004517 denotes nitric oxide synthase
T790 1907-1916 http://purl.obolibrary.org/obo/GO_0016701 denotes oxygenase
T789 2313-2324 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T788 1564-1575 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T787 2554-2569 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T786 1524-1539 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T785 3009-3025 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T784 2385-2401 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T783 2116-2132 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T782 2075-2094 http://purl.obolibrary.org/obo/GO_0051092 denotes activators of NF-κB
T781 1494-1513 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T780 1369-1377 http://purl.obolibrary.org/obo/GO_0009056 denotes degrades
T779 1323-1332 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T778 1265-1285 http://purl.obolibrary.org/obo/GO_0008283 denotes cells. Proliferation
T777 868-880 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T15772 27757-27769 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T15771 27731-27741 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T15770 27580-27590 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T15769 27717-27722 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1R
T15768 27566-27571 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1R
T15767 27494-27499 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1R
T15766 27410-27423 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1 receptor
T15765 27358-27371 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1 receptor
T2490 3140-3152 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T100 141-151 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T101 87-100 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T102 155-167 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T103 369-385 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signalling
T104 580-596 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signalling
T105 375-385 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T106 586-596 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T107 635-647 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T99 9-19 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation

GO-MF

Id Subject Object Predicate Lexical cue
T21775 15028-15031 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T21774 14235-14242 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T21773 14228-14234 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T21772 14067-14076 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T21771 14579-14582 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T21770 14555-14558 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T21769 14513-14516 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T21768 14473-14476 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T21767 14207-14210 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T21766 14194-14197 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T21765 14028-14031 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T21764 13982-13985 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T20062 10617-10628 http://purl.obolibrary.org/obo/GO_0004896 denotes receptor/IL
T20061 10626-10631 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1R
T20060 10342-10347 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1R
T20059 10294-10297 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T20058 10001-10017 http://purl.obolibrary.org/obo/GO_0035662 denotes TLR4 for binding
T20057 9717-9734 http://purl.obolibrary.org/obo/GO_0043130 denotes ubiquitin-binding
T20056 9551-9575 http://purl.obolibrary.org/obo/GO_0004843 denotes deubiquitinating enzymes
T20055 9430-9445 http://purl.obolibrary.org/obo/GO_0016874 denotes ligase activity
T20054 9420-9445 http://purl.obolibrary.org/obo/GO_0034450 denotes ubiquitin ligase activity
T20053 9420-9445 http://purl.obolibrary.org/obo/GO_0061630 denotes ubiquitin ligase activity
T20052 9420-9445 http://purl.obolibrary.org/obo/GO_1990757 denotes ubiquitin ligase activity
T20051 9420-9445 http://purl.obolibrary.org/obo/GO_0050372 denotes ubiquitin ligase activity
T20050 9420-9445 http://purl.obolibrary.org/obo/GO_0004842 denotes ubiquitin ligase activity
T20049 9717-9726 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T20048 9420-9429 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T20047 8886-8895 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T20046 10204-10211 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T20045 10010-10017 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T20044 9727-9734 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T20043 8592-8598 http://purl.obolibrary.org/obo/GO_0005488 denotes Ligand
T18006 32575-32579 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T18005 32569-32577 http://purl.obolibrary.org/obo/GO_0005149 denotes 1 and IL
T18004 31263-31268 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T16699 29639-29662 http://purl.obolibrary.org/obo/GO_0005102 denotes binding to the receptor
T16698 29639-29646 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T16697 28808-28823 http://purl.obolibrary.org/obo/GO_0016874 denotes ligase activity
T16696 28798-28823 http://purl.obolibrary.org/obo/GO_0034450 denotes ubiquitin ligase activity
T16695 28798-28823 http://purl.obolibrary.org/obo/GO_0061630 denotes ubiquitin ligase activity
T16694 28798-28823 http://purl.obolibrary.org/obo/GO_1990757 denotes ubiquitin ligase activity
T16693 28798-28823 http://purl.obolibrary.org/obo/GO_0050372 denotes ubiquitin ligase activity
T16692 28798-28823 http://purl.obolibrary.org/obo/GO_0004842 denotes ubiquitin ligase activity
T16691 28798-28807 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T15783 27717-27722 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1R
T15782 27566-27571 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1R
T14599 26781-26788 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T14598 26771-26788 http://purl.obolibrary.org/obo/GO_0043130 denotes ubiquitin-binding
T14597 26771-26780 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T14596 25588-25611 http://purl.obolibrary.org/obo/GO_0004843 denotes deubiquitinating enzyme
T13150 23810-23827 http://purl.obolibrary.org/obo/GO_0043130 denotes ubiquitin-binding
T13149 23177-23194 http://purl.obolibrary.org/obo/GO_0043130 denotes ubiquitin-binding
T13148 23810-23819 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T13147 23177-23186 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T13146 23820-23827 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T13145 23187-23194 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T13144 22870-22877 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T10723 20680-20685 http://purl.obolibrary.org/obo/GO_0030367 denotes IL-17
T10722 20654-20664 http://purl.obolibrary.org/obo/GO_0042056 denotes attractant
T10721 20618-20622 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T10720 18887-18904 http://purl.obolibrary.org/obo/GO_0008157 denotes binding protein 1
T10719 18887-18902 http://purl.obolibrary.org/obo/GO_0005515 denotes binding protein
T10718 18792-18809 http://purl.obolibrary.org/obo/GO_0043130 denotes ubiquitin-binding
T10717 18589-18591 http://purl.obolibrary.org/obo/GO_0061667 denotes E3
T10716 18589-18591 http://purl.obolibrary.org/obo/GO_0061666 denotes E3
T10715 18589-18591 http://purl.obolibrary.org/obo/GO_0061665 denotes E3
T10714 18589-18591 http://purl.obolibrary.org/obo/GO_0061664 denotes E3
T10713 18589-18591 http://purl.obolibrary.org/obo/GO_0061663 denotes E3
T10712 18589-18591 http://purl.obolibrary.org/obo/GO_0061662 denotes E3
T10711 18589-18591 http://purl.obolibrary.org/obo/GO_0061661 denotes E3
T10710 18589-18591 http://purl.obolibrary.org/obo/GO_0061660 denotes E3
T10709 18589-18591 http://purl.obolibrary.org/obo/GO_0061659 denotes E3
T10708 18589-18591 http://purl.obolibrary.org/obo/GO_0061630 denotes E3
T10707 18533-18535 http://purl.obolibrary.org/obo/GO_0061658 denotes E2
T10706 18533-18535 http://purl.obolibrary.org/obo/GO_0061657 denotes E2
T10705 18533-18535 http://purl.obolibrary.org/obo/GO_0061656 denotes E2
T10704 18533-18535 http://purl.obolibrary.org/obo/GO_0061655 denotes E2
T10703 18533-18535 http://purl.obolibrary.org/obo/GO_0061654 denotes E2
T8758 17680-17683 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T5681 15780-15784 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T5680 15761-15764 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T5679 13777-13780 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T5678 13725-13728 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T5677 13426-13429 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T5676 13330-13333 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T5675 13185-13188 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T5674 13179-13182 http://purl.obolibrary.org/obo/GO_0004704 denotes NIK
T5673 12385-12390 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1R
T5672 12065-12078 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1 receptor
T5671 11767-11775 http://purl.obolibrary.org/obo/GO_0043495 denotes anchored
T5670 11586-11588 http://purl.obolibrary.org/obo/GO_0061658 denotes E2
T5669 11586-11588 http://purl.obolibrary.org/obo/GO_0061657 denotes E2
T5668 11586-11588 http://purl.obolibrary.org/obo/GO_0061656 denotes E2
T5667 11586-11588 http://purl.obolibrary.org/obo/GO_0061655 denotes E2
T5666 11586-11588 http://purl.obolibrary.org/obo/GO_0061654 denotes E2
T5665 11586-11588 http://purl.obolibrary.org/obo/GO_0061653 denotes E2
T5664 11586-11588 http://purl.obolibrary.org/obo/GO_0061652 denotes E2
T5663 11586-11588 http://purl.obolibrary.org/obo/GO_0061651 denotes E2
T5630 10985-10987 http://purl.obolibrary.org/obo/GO_0061660 denotes E3
T5629 11589-11591 http://purl.obolibrary.org/obo/GO_0061659 denotes E3
T5628 11080-11082 http://purl.obolibrary.org/obo/GO_0061659 denotes E3
T5627 10985-10987 http://purl.obolibrary.org/obo/GO_0061659 denotes E3
T5626 11589-11591 http://purl.obolibrary.org/obo/GO_0061630 denotes E3
T5625 11080-11082 http://purl.obolibrary.org/obo/GO_0061630 denotes E3
T5624 10985-10987 http://purl.obolibrary.org/obo/GO_0061630 denotes E3
T5623 11586-11588 http://purl.obolibrary.org/obo/GO_0019787 denotes E2
T5622 11080-11082 http://purl.obolibrary.org/obo/GO_0019787 denotes E3
T5621 10985-10987 http://purl.obolibrary.org/obo/GO_0019787 denotes E3
T5620 11586-11588 http://purl.obolibrary.org/obo/GO_0004842 denotes E2
T5619 11080-11082 http://purl.obolibrary.org/obo/GO_0004842 denotes E3
T5618 10985-10987 http://purl.obolibrary.org/obo/GO_0004842 denotes E3
T5617 12606-12609 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T5616 11459-11462 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T5615 8220-8223 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T5614 8063-8066 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T5613 12065-12069 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T5612 7813-7817 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T5611 15340-15346 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T5610 7845-7852 http://purl.obolibrary.org/obo/GO_0005488 denotes ligands
T5609 11498-11505 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T5608 7215-7222 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T5607 7211-7222 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T810 2682-2688 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T809 1942-1963 http://purl.obolibrary.org/obo/GO_0050998 denotes nitric oxide synthase
T808 1942-1963 http://purl.obolibrary.org/obo/GO_0004517 denotes nitric oxide synthase
T807 1907-1916 http://purl.obolibrary.org/obo/GO_0016701 denotes oxygenase
T806 1895-1899 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T805 2043-2047 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T804 1889-1893 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T10702 18533-18535 http://purl.obolibrary.org/obo/GO_0061653 denotes E2
T10701 18533-18535 http://purl.obolibrary.org/obo/GO_0061652 denotes E2
T10700 18533-18535 http://purl.obolibrary.org/obo/GO_0061651 denotes E2
T10699 18533-18535 http://purl.obolibrary.org/obo/GO_0061650 denotes E2
T10698 18533-18535 http://purl.obolibrary.org/obo/GO_0061631 denotes E2
T10697 18589-18591 http://purl.obolibrary.org/obo/GO_0019787 denotes E3
T10696 18533-18535 http://purl.obolibrary.org/obo/GO_0019787 denotes E2
T10695 18589-18591 http://purl.obolibrary.org/obo/GO_0004842 denotes E3
T10694 18533-18535 http://purl.obolibrary.org/obo/GO_0004842 denotes E2
T10693 18887-18894 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T10692 18842-18849 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T10691 18802-18809 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T10690 18202-18209 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T10689 18191-18209 http://purl.obolibrary.org/obo/GO_0000166 denotes nucleotide-binding
T10688 20673-20682 http://purl.obolibrary.org/obo/GO_0005149 denotes 1, and IL
T10687 18137-18141 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T10686 18792-18801 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T10685 18592-18601 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T10684 18536-18545 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T10683 17986-17995 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T5662 11586-11588 http://purl.obolibrary.org/obo/GO_0061650 denotes E2
T5661 11586-11588 http://purl.obolibrary.org/obo/GO_0061631 denotes E2
T5660 11498-11514 http://purl.obolibrary.org/obo/GO_0005515 denotes binding proteins
T5659 11488-11514 http://purl.obolibrary.org/obo/GO_0032182 denotes ubiquitin-binding proteins
T5658 11488-11514 http://purl.obolibrary.org/obo/GO_0031625 denotes ubiquitin-binding proteins
T5657 11488-11505 http://purl.obolibrary.org/obo/GO_0043130 denotes ubiquitin-binding
T5656 11488-11497 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T5655 11083-11092 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T5654 10988-10997 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T5653 11589-11591 http://purl.obolibrary.org/obo/GO_0061667 denotes E3
T5652 11080-11082 http://purl.obolibrary.org/obo/GO_0061667 denotes E3
T5651 10985-10987 http://purl.obolibrary.org/obo/GO_0061667 denotes E3
T5650 11589-11591 http://purl.obolibrary.org/obo/GO_0061666 denotes E3
T5649 11080-11082 http://purl.obolibrary.org/obo/GO_0061666 denotes E3
T5648 10985-10987 http://purl.obolibrary.org/obo/GO_0061666 denotes E3
T5647 11589-11591 http://purl.obolibrary.org/obo/GO_0061665 denotes E3
T5646 11080-11082 http://purl.obolibrary.org/obo/GO_0061665 denotes E3
T5645 10985-10987 http://purl.obolibrary.org/obo/GO_0061665 denotes E3
T5644 11589-11591 http://purl.obolibrary.org/obo/GO_0061664 denotes E3
T5643 11080-11082 http://purl.obolibrary.org/obo/GO_0061664 denotes E3
T5642 10985-10987 http://purl.obolibrary.org/obo/GO_0061664 denotes E3
T5641 11589-11591 http://purl.obolibrary.org/obo/GO_0061663 denotes E3
T5640 11080-11082 http://purl.obolibrary.org/obo/GO_0061663 denotes E3
T5639 10985-10987 http://purl.obolibrary.org/obo/GO_0061663 denotes E3
T5638 11589-11591 http://purl.obolibrary.org/obo/GO_0061662 denotes E3
T5637 11080-11082 http://purl.obolibrary.org/obo/GO_0061662 denotes E3
T5636 10985-10987 http://purl.obolibrary.org/obo/GO_0061662 denotes E3
T5635 11589-11591 http://purl.obolibrary.org/obo/GO_0061661 denotes E3
T5634 11080-11082 http://purl.obolibrary.org/obo/GO_0061661 denotes E3
T5633 10985-10987 http://purl.obolibrary.org/obo/GO_0061661 denotes E3
T5632 11589-11591 http://purl.obolibrary.org/obo/GO_0061660 denotes E3
T5631 11080-11082 http://purl.obolibrary.org/obo/GO_0061660 denotes E3
T15781 27494-27499 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1R
T15780 27410-27423 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1 receptor
T15779 27358-27371 http://purl.obolibrary.org/obo/GO_0004908 denotes IL-1 receptor
T15778 27410-27414 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T15777 27358-27362 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T15776 27395-27409 http://purl.obolibrary.org/obo/GO_0003823 denotes immunoglobulin
T15775 27343-27357 http://purl.obolibrary.org/obo/GO_0003823 denotes immunoglobulin
T2530 6455-6471 http://purl.obolibrary.org/obo/GO_0005515 denotes binding proteins
T2529 6447-6471 http://purl.obolibrary.org/obo/GO_0048306 denotes calcium-binding proteins
T2528 6202-6212 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T2527 4716-4726 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T2526 4538-4548 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T2525 6874-6881 http://purl.obolibrary.org/obo/GO_0005488 denotes ligands
T2524 6635-6642 http://purl.obolibrary.org/obo/GO_0005488 denotes ligands
T2523 6104-6111 http://purl.obolibrary.org/obo/GO_0005488 denotes ligands
T2522 5632-5639 http://purl.obolibrary.org/obo/GO_0005488 denotes ligands
T2521 5385-5392 http://purl.obolibrary.org/obo/GO_0005488 denotes ligands
T2520 5341-5348 http://purl.obolibrary.org/obo/GO_0005488 denotes ligands
T2519 4227-4233 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T2518 4207-4214 http://purl.obolibrary.org/obo/GO_0005488 denotes Binding
T2517 3458-3462 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1
T2516 3324-3328 http://purl.obolibrary.org/obo/GO_0005149 denotes IL-1

GO-CC

Id Subject Object Predicate Lexical cue
T21779 14050-14084 http://purl.obolibrary.org/obo/GO_0000153 denotes complex with the ubiquitin ligases
T21778 14050-14084 http://purl.obolibrary.org/obo/GO_0000151 denotes complex with the ubiquitin ligases
T21777 14573-14577 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T21776 14022-14027 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T20066 9931-9944 http://purl.obolibrary.org/obo/GO_0044214 denotes transmembrane
T20065 9931-9944 http://purl.obolibrary.org/obo/GO_0016021 denotes transmembrane
T20064 9356-9363 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T20063 8622-8630 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T18008 31281-31286 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18007 31193-31198 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16703 29498-29503 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16702 29356-29361 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16701 29140-29145 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16700 28979-28983 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T14604 26249-26253 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T14603 26015-26019 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T14602 25922-25926 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T14601 25685-25689 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T14600 25494-25498 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T13151 25044-25048 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T10734 21850-21860 http://purl.obolibrary.org/obo/GO_0005694 denotes chromosome
T10733 21561-21566 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10732 21550-21555 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10731 21541-21546 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10730 21477-21481 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T10729 19973-19977 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T10728 19906-19910 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T10727 19026-19030 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T8760 16339-16344 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8759 16007-16025 http://purl.obolibrary.org/obo/GO_0042995 denotes cellular processes
T5694 15719-15724 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5693 13323-13328 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5692 13295-13299 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5691 12967-12971 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5690 12065-12078 http://purl.obolibrary.org/obo/GO_0045323 denotes IL-1 receptor
T5689 11592-11606 http://purl.obolibrary.org/obo/GO_1902494 denotes enzyme complex
T5688 13476-13486 http://purl.obolibrary.org/obo/GO_0000502 denotes proteasome
T5687 12849-12859 http://purl.obolibrary.org/obo/GO_0000502 denotes proteasome
T5686 8199-8209 http://purl.obolibrary.org/obo/GO_0000502 denotes proteasome
T5685 8220-8231 http://purl.obolibrary.org/obo/GO_0008385 denotes IKK complex
T5684 8063-8075 http://purl.obolibrary.org/obo/GO_0008385 denotes IKK) complex
T5683 7428-7435 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T5682 7062-7071 http://purl.obolibrary.org/obo/GO_0005737 denotes cytoplasm
T812 1265-1270 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T811 1021-1026 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T21785 14050-14084 http://purl.obolibrary.org/obo/GO_0000836 denotes complex with the ubiquitin ligases
T21784 14050-14084 http://purl.obolibrary.org/obo/GO_0043494 denotes complex with the ubiquitin ligases
T21783 14050-14084 http://purl.obolibrary.org/obo/GO_0019005 denotes complex with the ubiquitin ligases
T21782 14050-14084 http://purl.obolibrary.org/obo/GO_0000152 denotes complex with the ubiquitin ligases
T21781 14050-14084 http://purl.obolibrary.org/obo/GO_0000837 denotes complex with the ubiquitin ligases
T21780 14050-14084 http://purl.obolibrary.org/obo/GO_0000835 denotes complex with the ubiquitin ligases
T15786 28133-28138 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15785 27962-27967 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15784 27922-27927 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2543 5954-5963 http://purl.obolibrary.org/obo/GO_0000785 denotes chromatin
T2542 5904-5915 http://purl.obolibrary.org/obo/GO_0005694 denotes chromosomal
T2541 5428-5432 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T2540 6202-6212 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T2539 4716-4726 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T2538 4538-4548 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T2537 6202-6212 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T2536 4716-4726 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T2535 4538-4548 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T2534 6053-6058 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2533 5445-5450 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2532 4812-4816 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2531 3993-3997 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2547 6724-6734 http://purl.obolibrary.org/obo/GO_0005577 denotes fibrinogen
T2546 6684-6715 http://purl.obolibrary.org/obo/GO_0044420 denotes extracellular matrix components
T2545 6684-6704 http://purl.obolibrary.org/obo/GO_0031012 denotes extracellular matrix
T2544 6684-6697 http://purl.obolibrary.org/obo/GO_0005576 denotes extracellular

sentences

Id Subject Object Predicate Lexical cue
T21404 14223-14387 Sentence denotes Upon ligand binding, TRAF3 is recruited to the receptor, where TRAF2 directs nondegradative K63-linked polyubiquitination of cIAP1/2, resulting in their activation.
T21403 14006-14222 Sentence denotes In unstimulated cells NIK forms a cytosolic complex with the ubiquitin ligases TRAF2, TRAF3 and cIAP1/2, which facilitates the K48-linked polyubiquitination and proteasomal degradation of NIK, keeping NIK levels low.
T21402 13880-14005 Sentence denotes CD40 and RANK can activate the noncanonical NF-κB pathway that is dependent on NF-κB inducing kinase (NIK) expression levels.
T21401 13849-13879 Sentence denotes Noncanonical NF-κB signalling.
T21409 14831-15166 Sentence denotes Next to TRAF3, TRAF1 has also been identified as a negative regulator of this pathway, most probably by competing with other TNF receptor-associated factors. cIAP, cellular inhibitor of apoptosis; IKK, IκB kinase; NF, nuclear factor; RANK, receptor activator of NF-κB; TRAF, TNF receptor-associated factor; TNF, tumour necrosis factor.
T21408 14666-14830 Sentence denotes This is followed by K48-linked polyubiquitination and partial proteasomal degradation of p100 to p52, which forms a heterodimer with RelB to activate transcription.
T21407 14579-14665 Sentence denotes NIK then phosphorylates and activates IKK1, which mediates NF-κB p100 phosphorylation.
T21406 14478-14578 Sentence denotes As a result, TRAF3 is degraded and NIK is stabilised, resulting in increased NIK levels in the cell.
T21405 14388-14477 Sentence denotes Subsequently cIAP1/2 directs its K48-linked polyubiquitination to TRAF3, rather than NIK.
T19469 10194-10724 Sentence denotes ABIN, A20-binding inhibitor of NF-κB; cIAP, cellular inhibitor of apoptosis; CYLD, cylindromatosis; IKK, IκB kinase; IκB, inhibitor of NF-κB; IRAK, IL-1R-associated kinase; MyD88, myeloid differentiation primary response gene 88; NEMO, NF-κB essential modulator; NF, nuclear factor; RANK, receptor activator of NF-κB; RIP1, receptor interacting protein 1; SIGIRR, single-immunoglobulinIL-1 receptor-related; TIR, Toll-like receptor/IL-1R; TRAF, TNF receptor-associated factor; TLR, Toll-like receptor; TNF, tumour necrosis factor.
T19468 10038-10193 Sentence denotes The expression of many of these negative regulatory molecules is NF-κB dependent, implicating them in the negative feedback regulation of NF-κB activation.
T19467 9878-10037 Sentence denotes Finally, TLR signalling can also be inhibited by the transmembrane protein SIGIRR, which has been proposed to compete with TLR4 for binding to IRAK1 and TRAF6.
T19466 9534-9877 Sentence denotes A20 and CYLD are deubiquitinating enzymes that control NF-κB activation by targeting specific signalling proteins including RIP1 and TRAF6, to which they are recruited using specific ubiquitin-binding adaptor proteins such as ABIN-1 and p62. miR-146 is thought to negatively regulate TLR signalling by inhibiting expression of IRAK1 and TRAF6.
T19465 9400-9533 Sentence denotes TRAF1, which has no ubiquitin ligase activity, can negatively regulate NF-κB activation, most probably by competing with other TRAFs.
T19464 9271-9399 Sentence denotes This allows NF-κB (here shown as a heterodimer of p65 and p50) to translocate to the nucleus and promote target gene expression.
T19463 9121-9270 Sentence denotes TAK1 then phosphorylates and activates IKK2, which in turn phosphorylates IκBα, triggering its K48-linked ubiquitination and proteasomal degradation.
T19462 8950-9120 Sentence denotes K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1, is recognised by NEMO and TAB proteins, resulting in the recruitment and activation of respectively IKK2 and TAK1.
T19461 8592-8949 Sentence denotes Ligand engagement of specific membrane receptors such as TNFR1, CD40, RANK, and TLR4 trigger the recruitment of specific adaptor proteins (TNF receptor 1-associated death domain protein (TRADD), MyD88, MAL, TIR domain-containing adaptor-inducing IFNβ (TRIF)), kinases (RIP1, IRAK1, IRAK4), and ubiquitin ligases (TRAF2, TRAF6, cIAP1, cIAP2) to the receptor.
T19460 8540-8591 Sentence denotes Canonical NF-κB signalling and negative regulators.
T17449 32629-32809 Sentence denotes Finally, miR-16, miR-132, and miR-223 were also shown to have an altered expression in RA patients, indicating their potential as diagnostic biomarkers for pathogenesis [83,88,91].
T17448 32470-32628 Sentence denotes Similarly, elevated levels of miR-203 - leading to increased secretion of matrix metalloproteinase-1 and IL-6 - were detected in RA synovial fibroblasts [90].
T17447 32307-32469 Sentence denotes In this context, miR-124a - a key regulator of the chemokine monocyte chemoattractant protein 1 - was shown to be decreased in synoviocytes from RA patients [89].
T17446 32132-32306 Sentence denotes Besides miR-146 and miR-155, a number of other miRNAs with a potential role in the control of NF-κB-dependent inflammatory responses in RA pathology were recently identified.
T17445 31905-32131 Sentence denotes In addition, their increased expression in RA patients is potentially useful as a marker for disease diagnosis, progression, or treatment efficacy [88], but this will require confirmation using a large and well-defined cohort.
T17444 31641-31904 Sentence denotes Moreover, miR-155 was shown to promote TNF production, a key process in the pathogenesis of RA [87]. miR-146 and miR-155 may therefore be important negative regulators of inflammation in RA and their potential for the development of new treatments is substantial.
T17443 31313-31640 Sentence denotes Interestingly, a polymorphism in the 3'-UTR of the miR-146a target gene was recently shown to be associated with RA susceptibility [86]. miR-155 overexpression in synovial fibroblasts was able to prevent the TLR and cytokine-inducible expression of specific matrix metalloproteinases that mediate tissue destruction in RA [81].
T17442 31029-31312 Sentence denotes Notably, both miR-146 and miR-155 are expressed at higher levels in RA synovial fibroblasts and synovial tissue [81,82], as well as in peripheral blood mononuclear cells of RA patients [83]. miR-146a is also overexpressed in CD4+ and IL-17-producing T cells from RA patients [84,85].
T17441 30920-31028 Sentence denotes Similarly, miR-155 was shown to target transcripts for the NF-κB signalling molecules IKKε and RIP1 [79,80].
T17440 30758-30919 Sentence denotes In addition, miR-146a is an NF-κB-dependent gene, and the NF-κB signalling molecules IRAK1 and TRAF6 were identified as target genes of miR-146a [78] (Figure 1).
T17439 30575-30757 Sentence denotes miR-146a/b and miR-155 are of particular interest for inflammatory signalling to NF-κB, since these miRNAs can be induced by inflammatory stimuli such as IL-1β, TNF and TLRs [78,79].
T17438 30439-30574 Sentence denotes They bind the 3'-UTR of target mRNAs leading to the repression of protein expression and the promotion of target mRNA degradation [77].
T17437 30228-30438 Sentence denotes miRNAs are recently discovered regulators of gene expression and represent a class of noncoding RNA molecules essential in many cellular and developmental processes, including immune responses and inflammation.
T17436 30218-30227 Sentence denotes microRNAs
T16375 30110-30216 Sentence denotes Recent work in a Korean population also demonstrates genetic association of the TRAF1 region with RA [76].
T16374 30026-30109 Sentence denotes Subsequent work indicates that TRAF1 is more likely to be the causative locus [75].
T16373 29776-30025 Sentence denotes A genome-wide association study examining more than 300,000 SNPs among approximately 1,500 autoantibody-positive RA cases and 1,800 controls identified a genetic variation at the TRAF1-complement component 5 locus as an important RA risk locus [74].
T16372 29693-29775 Sentence denotes Alternatively, TRAF1 might recruit A20 with which it can physically interact [73].
T16371 29580-29692 Sentence denotes Most probably, TRAF1 competes with TRAF family members for binding to the receptor or other signalling proteins.
T16370 29505-29579 Sentence denotes The mechanism by which TRAF1 modulates NF- κB activation is still unclear.
T16369 29330-29504 Sentence denotes TRAF1-deficient dendritic cells, however, show attenuated responses to secondary stimulation by TRAF2-dependent factors, suggesting a positive regulatory role in these cells.
T16368 29251-29329 Sentence denotes TRAF1 also functions as a negative regulator of CD40-induced NF-κB activation.
T16367 29122-29250 Sentence denotes TRAF1-deficient T cells are hyper-responsive to TNF, with enhanced proliferation and activation of the NF-κB signalling pathway.
T16366 29015-29121 Sentence denotes Expression of TRAF1 is inducible by TNF and overexpression of TRAF1 inhibits TNF-induced NF-κB activation.
T16365 28825-29014 Sentence denotes Accumulating data support a role for TRAF1 as both a negative and a positive modulator of NF-κB signalling by certain TNF family receptors, possibly in a cell-type-dependent manner [71,72].
T16364 28688-28824 Sentence denotes TRAF1 is a unique member of the TRAF protein family because it lacks a RING finger domain and therefore lacks ubiquitin ligase activity.
T16363 28655-28687 Sentence denotes TNF receptor-associated factor 1
T15491 28548-28653 Sentence denotes Because of its restricted expression pattern, SIGIRR may also be an interesting therapeutic target in RA.
T15490 28353-28547 Sentence denotes It will be interesting to compare the expression of SIGIRR in RA patients with its expression in control patients, or to investigate whether the function of SIGIRR is compromised in RA patients.
T15489 28140-28352 Sentence denotes This inhibitory function of SIGIRR was further confirmed in vivo, since SIGIRR-deficient mice developed a more severe disease in zymosan-induced arthritis, as well as collagen-induced arthritis mouse models [70].
T15488 28009-28139 Sentence denotes Recently, SIGIRR overexpression was shown to inhibit the spontaneous release of inflammatory cytokines by human RA synovial cells.
T15487 27843-28008 Sentence denotes SIGIRR has a very restricted expression pattern, being expressed in epithelial cells, monocytes and immature dendritic cells, but not in mature macro-phages [69,70].
T15486 27689-27842 Sentence denotes Given the important role of IL-1R and TLR signalling in the chronic inflammation observed in RA [68], a regulatory role for SIGIRR in RA is not unlikely.
T15485 27388-27688 Sentence denotes Single-immunoglobulin IL-1 receptor-related (SIGIRR) protein, also known as TIR-8, is a member of the TLR/IL-1R family that has been extensively characterised as an inhibitor of IL-1R and TLR signalling, probably through direct interaction with these receptors, MyD88, IRAK1 or TRAF6 [67] (Figure 1).
T15484 27336-27387 Sentence denotes Single-immunoglobulin IL-1 receptor-related protein
T14151 27078-27334 Sentence denotes These findings suggest that CYLD-mediated inhibi-tion of RANK-induced NF-κB signalling plays a key role in the negative regulation of osteoclastogenesis and indicate CYLD as a potential genetic factor involved in the pathology of bone disorders such as RA.
T14150 26903-27077 Sentence denotes In this context, it is worth mentioning that transgenic mice expressing a mutated form of p62 also display abnormal osteoclastogenesis and develop progressive bone loss [66].
T14149 26630-26902 Sentence denotes CYLD expression is markedly upregulated under conditions of RANKL-induced osteoclastogenesis and is recruited to ubiquitinated TRAF6 via the ubiquitin-binding adaptor protein p62 (also known as sequestosome 1) [65], followed by the CYLD-mediated deubiquitination of TRAF6.
T14148 26499-26629 Sentence denotes Osteoclast precursors of these mice are hyper-responsive to RANKL-induced differentiation and produce more and larger osteoclasts.
T14147 26386-26498 Sentence denotes Mice with a genetic deficiency of CYLD have aberrant osteoclast differentiation and develop severe osteoporosis.
T14146 26275-26385 Sentence denotes Interestingly, CYLD has been shown to negatively regulate RANK signalling and osteoclastogenesis in mice [65].
T14145 26198-26274 Sentence denotes In addition, their relative activity might also be cell-type dependent [64].
T14144 25982-26197 Sentence denotes As A20 is only expressed in many cell types upon stimulation, it has been suggested that this protein mainly regulates later phases of NF-κB signalling, whereas CYLD would regulate constitutive and early signalling.
T14143 25849-25981 Sentence denotes Many of these are also targeted by A20 and it is still not clear why the cell needs A20 as well as CYLD to control NF-κB activation.
T14142 25578-25848 Sentence denotes CYLD is a deubiquitinating enzyme that negatively regulates NF-κB signalling initiated by TNFR, RANK and T-cell receptor stimulation (reviewed in [64]) (Figure 1), by deubiquitina-ting several NF-κB signalling proteins including NEMO, TRAF2, TRAF6, TRAF7, RIP1 and TAK1.
T14141 25385-25577 Sentence denotes CYLD is also involved, however, in diverse physiological processes ranging from immunity and inflammation to cell cycle progression, spermatogenesis, and osteoclastogenesis (reviewed in [64]).
T14140 25262-25384 Sentence denotes Cylindromatosis (CYLD) protein was originally identified as a tumour suppressor involved in familial cylindromatosis [63].
T14139 25238-25261 Sentence denotes Cylindromatosis protein
T12654 25072-25236 Sentence denotes It will therefore be interesting to investigate whether SNPs that have been reported to be associated with systemic lupus erythematosus are also associated with RA.
T12653 24788-25071 Sentence denotes A high degree of overlap between systemic lupus erythematosus and RA susceptibility loci might be expected as the two diseases show some clinical overlap in joint involvement, autoantibody production, systemic features and response to treatments such as B-cell depletion (rituximab).
T12652 24664-24787 Sentence denotes Interestingly, ABIN-1 polymorphisms have been associated with psoriasis and systemic lupus erythematosus in humans [61,62].
T12651 24542-24663 Sentence denotes Moreover, this protective effect of the ITAM was strongly suppressed in inflammatory arthritis synovial macrophages [60].
T12650 24333-24541 Sentence denotes In a recent study, inhibition of TLR responses by immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptors was shown to depend on the expression of the NF-κB inhibitory proteins ABIN-3 and A20.
T12649 24005-24332 Sentence denotes Using oligonucleotide microarray analysis, ABIN-1 was identified among TNF-induced genes in human synoviocytes, and high levels of ABIN-1 mRNA were detected in RA tissue biopsies, indicating a potential role for ABIN-1, together with A20, in the negative feedback regulation of NF-κB signalling and the pathogenesis of RA [59].
T12648 23841-24004 Sentence denotes As for A20, ABIN-1 also strongly inhibits TNF-induced apoptosis [58], and ABIN-1 deficient mice die embryonically due to TNF-dependent foetal liver apoptosis [56].
T12647 23696-23840 Sentence denotes Functional ABIN-3 is expressed in humans, but mice only express a truncated and inactive form lacking the crucial ubiquitin-binding domain [57].
T12646 23476-23695 Sentence denotes Unexpectedly, both ABIN-1-deficient and ABIN-2-deficient mice exhibit only slightly increased or normal NF-κB responses, respectively, possibly reflecting redundant NF-κB inhibitory activities of multiple ABINs [55,56].
T12645 23281-23475 Sentence denotes Similar to A20, ABIN-1 and ABIN-3 expression is NF-κB dependent, implicating a potential role for the A20/ABIN complex in the negative feedback regulation of NF-κB activation (reviewed in [54]).
T12644 23144-23280 Sentence denotes Because ABINs contain a specific ubiquitin-binding motif, they have been proposed to target A20 to polyubiquitinated substrates [43,44].
T12643 22898-23143 Sentence denotes ABIN-1, ABIN-2 and ABIN-3 (also known as TNIP-1, TNIP-2, and TNIP-3) were identified as ubiquitously expressed A20 interacting proteins and were shown to inhibit NF-κB activation by TNF and several other inflammatory stimuli upon overexpression.
T12642 22866-22897 Sentence denotes A20-binding inhibitors of NF-κB
T9668 22739-22864 Sentence denotes In this context, knockin mice for the corresponding A20 SNPs, combined with mouse models for RA, will be very valuable tools.
T9667 22613-22738 Sentence denotes It will be of interest to identify the actual causal variants and to elucidate the functional consequences of these variants.
T9666 22388-22612 Sentence denotes Recently, Elsby and colleagues functionally evaluated in vitro the regulatory ability of RA-associated SNP variants on A20 promoter activity, and could show repressed A20 transcription for some of the SNPs investigated [53].
T9665 22294-22387 Sentence denotes How these variants affect normal A20 activity and how they cause RA, however, remain unclear.
T9664 22113-22293 Sentence denotes As A20 is required for termination of TNF-induced signals, and TNF is the primary inflammatory cytokine in RA, these findings reveal A20 as a candidate susceptibility locus for RA.
T9663 21892-22112 Sentence denotes Although the identified variants are not located in a gene, they are thought to influence A20 as its nearest gene (~150 kb downstream of A20), probably by the presence of potential regulatory DNA elements in this region.
T9662 21729-21891 Sentence denotes Several genome-wide association studies also revealed a clear association between mutations in the A20 locus in the 6q23 chromosome and susceptibility to RA [52].
T9661 21568-21728 Sentence denotes Importantly, several SNPs in the human A20 locus have been associated with increased susceptibility to development of autoimmune pathologies (reviewed in [52]).
T9660 21359-21567 Sentence denotes It will be interesting to analyse in future the susceptibility of conditional knockout mice that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells.
T9659 21257-21358 Sentence denotes A20 might therefore minimise joint destruction through decreasing the osteoclast number and activity.
T9658 21128-21256 Sentence denotes This study also demonstrated that A20 overexpression leads to a decrease in the number of activated osteoclasts in joint tissue.
T9657 20853-21127 Sentence denotes Because TNF and IL-1β are known to mediate synovitis, pannus formation, and erosion of cartilage and bone in RA, the decreased serum levels of TNF and IL-1β in A20-transduced mice might explain the beneficial effects in the clinical, pathological, and radiological findings.
T9656 20499-20852 Sentence denotes A20 expression in synovial tissue was associated with inhibition of NF-κB activity and decreased levels of TNF, IL-1β, IL-6, soluble RANKL, monocyte chemo-attractant protein 1, and IL-17, suggesting that A20 induces a protective effect in collagen-induced arthritis mice through suppression of NF-κB activation and NF- κB-dependent gene expression [51].
T9655 20229-20498 Sentence denotes Recently, intra-articular injection of an A20-expressing adenovirus was shown to reduce the severity of synovial inflammation and joint destruction in a mouse model of collagen-induced arthritis, even in untreated joints, in both a prophylactic and therapeutic setting.
T9654 20091-20228 Sentence denotes Interestingly, A20 expression is itself regulated by NF-κB [50], implicating A20 in the negative feedback regulation of NF-κB signalling.
T9653 19929-20090 Sentence denotes A20 expression has been observed in several cell types that play important roles in the pathophysiology of RA, such as fibroblasts, synoviocytes and lymphocytes.
T9652 19749-19928 Sentence denotes Two independent studies showed that mice lacking A20 in B cells develop autoimmunity due to hyperactive NF-κB responses in B cells leading to unrestricted B-cell survival [48,49].
T9651 19433-19748 Sentence denotes We recently showed that mice specifically lacking A20 in intestinal epithelial cells exhibit increased susceptibility to experimental colitis due to the hypersensitivity of their intestinal epithelial cells to TNF-induced apoptosis, confirming A20 as a major antiapoptotic protein in the intestinal epithelium [47].
T9650 19311-19432 Sentence denotes A20-deficient cells are also more susceptible to TNF-mediated apoptosis, confirming its role as an antiapoptotic protein.
T9649 19126-19310 Sentence denotes A20-deficient mice spontaneously develop multiorgan inflammation and cachexia and die within 2 weeks of birth, illustrating the potent anti-inflammatory function of this molecule [46].
T9648 19038-19125 Sentence denotes The mechanisms by which A20 regulates apoptotic signalling, however, are still elusive.
T9647 18914-19037 Sentence denotes Next to its role in suppressing NF-κB activation, A20 is also a strong inhibitor of apoptosis, at least in some cell types.
T9646 18734-18913 Sentence denotes The association of A20 with its targets requires specific ubiquitin-binding adaptor proteins, including A20-binding inhibitor of NF-κB (ABIN) 1 and Tax1-binding protein 1 [43-46].
T9645 18484-18733 Sentence denotes Recently, the disruption of interactions between E2 ubiquitin conjugating enzymes (Ubc13 and Ubc5hc) and E3 ubiquitin ligases (TRAF6, TRAF2 and cIAP1/2) were described as another important mechanism used by A20 to downregulate NF-κB signalling [42].
T9644 18275-18483 Sentence denotes A20 is believed to inhibit NF-κB function by deubiquitinating specific NF-κB signalling molecules, such as RIP1, RIP2, TRAF6 and MALT1, which disrupts specific protein-protein interactions [38-41] (Figure 1).
T9643 17953-18274 Sentence denotes A20 (also known as TNFAIP3) is a ubiquitin-editing protein that negatively regulates NF-κB-dependent gene expression in response to different immune-activating stimuli, including TNF, IL-1 and antigens, and the triggering of TLRs and the nucleotide-binding oligomerisation domain-containing 2 receptor (reviewed in [37]).
T9642 17941-17952 Sentence denotes A20 protein
T8388 17608-17939 Sentence denotes Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback regulation of the noncanonical NF-κB pathway [36], supporting the idea that IKK1 plays important roles in terminating both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA.
T8387 17480-17607 Sentence denotes IKK1 has also been shown to inhibit nuclear NF-κB and to downregulate proinflammatory signalling by phosphorylating STAT1 [35].
T8386 17280-17479 Sentence denotes Macrophages from IKK1-deficient mice or knockin mice expressing inactive IKK1 show increased production of proinflammatory cytokines as a result of enhanced IKK2 activation and IκBα degradation [34].
T8385 16963-17279 Sentence denotes These proteins are not discussed here, since a link with RA pathology has not yet been reported. Although IKK1 is a critical component of the non-canonical NF-κB pathway, it should be mentioned that this kinase also plays a prominent role in the negative regulation of both canonical and noncanonical NF-κB pathways.
T8384 16785-16962 Sentence denotes Several other proteins involved in the negative regulation of NF-κB-dependent inflammatory responses, such as MyD88s, IRAK-M, and TOLLIP, have been described (reviewed in [33]).
T8383 16678-16784 Sentence denotes In addition, we discuss the potential role of these NF-κB inhibitory factors in the immunopathology of RA.
T8382 16463-16677 Sentence denotes Below we give an overview of a number of proteins that are involved in the dampening or termination of the NF-κB response, some of them under the control of NF-κB itself and thus acting in a negative feedback loop.
T8381 16322-16462 Sentence denotes To achieve this, cells employ different mechanisms, including the expression of inhibitory proteins that downregulate NF-κB signalling [32].
T8380 16170-16321 Sentence denotes Moreover, terminating an NF-κB response is essential to prevent persistent NF-κB activation that may lead to chronic inflammation and/or tumorigenesis.
T8379 15962-16169 Sentence denotes Since NF-κB activation is so crucial to many cellular processes, a tight regulation of the NF-κB signalling pathway and the genes it induces is an absolute requirement to fine-tune the inflammatory response.
T4265 15701-15914 Sentence denotes For example, in B cells TRAF6 is required for CD40-mediated JNK activation and IL-6 production, while TRAF2 is required for activation of NF-κB, and TRAF3 serves as a negative regulator of CD40 signalling [30,31].
T4264 15607-15700 Sentence denotes Specific TRAF molecules are associated with overlapping and distinct CD40-mediated functions.
T4263 15318-15606 Sentence denotes Upon binding of their ligand, CD40 and RANK interact with several TRAF members, including TRAF1, TRAF2, TRAF3, TRAF5, and TRAF6, and this leads to the proteolysis of both TRAF2 and TRAF3, which represents an important step in the activation of the noncanonical pathway as described above.
T4262 15167-15317 Sentence denotes It should be mentioned that CD40, lymphotoxin β receptor and RANK mediate the activation of both canonical and noncanonical NF-κB signalling pathways.
T4261 13691-13838 Sentence denotes All this contributes to releasing NIK from its constitutive degradation, resulting in NIK accumulation and IKK1 phosphorylation [28,29] (Figure 2).
T4260 13488-13690 Sentence denotes Receptor ligation has been shown not only to remove TRAF3 from this complex by recruiting it to the receptor, but also to attract TRAF2 and cIAP1/2, which are essential for subsequent TRAF3 degradation.
T4259 13307-13487 Sentence denotes In unstimulated cells, NIK occurs in a cytoplasmic complex with TRAF2, TRAF3, and cIAP1/2, which K48-polyubiquitinates NIK, leading to its continuous degradation by the proteasome.
T4258 13185-13306 Sentence denotes NIK is predominantly regulated at the post-translational level and is present at extremely low levels in most cell types.
T4257 12807-13184 Sentence denotes In this pathway, p100 is processed by the proteasome to p52, which together with the RelB NF-κB subunit regulates a distinct set of target genes that control B-cell development, secondary lymphoid organ development, and osteoclastogenesis [27] The noncanonical NF-κB pathway is strictly dependent on IKK1, which is activated upon phosphorylation by NF-κB inducing kinase (NIK).
T4256 12686-12806 Sentence denotes The noncanonical NF-κB pathway can be activated by the lymphotoxin β receptor, BAFF receptor, CD40, and RANK (Figure 2).
T4255 12569-12685 Sentence denotes Both pathways then activate TAK1 and IKK in a ubiquitination-dependent manner similar to the TNF pathway (Figure 1).
T4254 12499-12568 Sentence denotes TRIF also recruits TRAF6 [25] and RIP1 [26] via a direct interaction.
T4253 12347-12498 Sentence denotes MyD88 in turn recruits members of the IL-1R-associated kinase (IRAK) family and TRAF6, leading to oligomerisation and selfubiquitination of TRAF6 [24].
T4252 11981-12346 Sentence denotes For example, TLR4 stimulation by lipopolysaccharide induces the recruitment of Toll/IL-1 receptor adaptor protein (also referred to as Mal) and TRIF-related adaptor molecule (TRAM), which most probably serve as bridging factors to recruit myeloid differentiation primary response gene 88 (MyD88) and TIR domain-containing adaptor-inducing IFNβ (TRIF), respectively.
T4251 11925-11980 Sentence denotes Similar signalling principles apply to other receptors.
T4250 11741-11924 Sentence denotes The exact role of protein-anchored polyubiquitin chains remains unclear, as it was recently suggested that unanchored polyubiquitin chains can directly activate the TAK1 complex [23].
T4249 11546-11740 Sentence denotes The recent identification of a distinct E2/E3 enzyme complex that modifies NEMO with linear polyubiquitin chains and is essential for TNF-activated NF-κB signalling adds further complexity [22].
T4248 11377-11545 Sentence denotes The polyubiquitin chains on RIP1 are believed to create a scaffold to recruit the IKK and TAK1 complex via the ubiquitin-binding proteins NEMO and TAB1/2, respectively.
T4247 11264-11376 Sentence denotes TRAF2/5 and cIAP1/2 are good candidates for RIP1 ubiquitination, but the specific role of each is still unclear.
T4246 11164-11263 Sentence denotes On TNF stimulation, TNF-receptor bound RIP1 is rapidly modified by K63-linked polyubiquitin chains.
T4245 10795-11163 Sentence denotes TNF stimulation results in the recruitment of TNF receptor-1-associated death domain (TRADD) protein and of receptor interacting protein 1 (RIP1), which function as adaptor proteins for the E3 ubiquitin ligases TNF receptor-associated factor (TRAF) 2 and TRAF5, which in turn bind the E3 ubiquitin ligases cellular inhibitor of apoptosis (cIAP) 1 and cIAP2 (Figure 1).
T4244 10725-10794 Sentence denotes One of the best studied NF-κB signalling pathways is the TNF pathway.
T4243 8412-8529 Sentence denotes Gene targeting experiments showed that IKK2 and NEMO, but not IKK1, are required for canonical NF-κB activation [21].
T4242 8216-8411 Sentence denotes The IKK complex is comprised of the two catalytic subunits IKK1 and IKK2 (also known as IKKα and IKKβ) and the regulatory subunit NF-κB essential modulator (NEMO - also known as IKKγ) (Figure 1).
T4241 7854-8215 Sentence denotes NF-κB signalling initiated by different receptors requires the formation of proximal protein-protein interactions that are often receptor specific, but ultimately converge in the activation of the IκB kinase (IKK) complex, which mediates phosphorylation of the inhibitory IκB protein leading to its K48-polyubiquitination and degradation by the proteasome [20].
T1758 3644-3902 Sentence denotes NF-κB activation by receptor activator of NF-κB (RANK), a TNF receptor family member, is important for osteoclastogenesis, and defects in proper RANK-NF-κB signalling are likely to be involved in RA pathology and other diseases associated with bone loss [7].
T1757 3450-3643 Sentence denotes TNF and IL-1 are both very potent activators of NF-κB and it can be expected that NF-κB activation by these cytokines mediates most of their pro-inflammatory activities in RA (reviewed in [3]).
T1756 3257-3449 Sentence denotes It is well accepted that proinflammatory cytokines such as TNF and IL-1 play an important role, and administration of TNF antagonists is an effective treatment for severe RA (reviewed in [9]).
T1755 3099-3256 Sentence denotes Since NF-κB is central to the process of inflammation in RA, much research deals with the identification of the molecular triggers that activate NF-κB in RA.
T4240 7645-7853 Sentence denotes The canonical NF-κB pathway plays a major role in innate and adaptive immunity, and is triggered by many stimuli including proinflammatory cytokines (for example, TNF, IL-1), antigens, RANKL, and TLR ligands.
T4239 7515-7644 Sentence denotes There are two unique NF-κB signalling pathways, termed canonical (or classical) and noncanonical (or alternative) NF-κB pathways.
T4238 7229-7514 Sentence denotes Whereas the majority of IκBs (IκBα, IκBβ, IκBε, p105 (also known as NF-κB1), p100 (also known as NF-κB2)) serve as inhibitors of NF-κB, IκBξ and Bcl-3 instead potentiate NF-κB transactivation in the nucleus. p100 and p105 are precursors of the p52 and p50 NF-κB subunits, respectively.
T4237 7024-7228 Sentence denotes NF-κB proteins are sequestered in the cytoplasm as latent complexes by inhibitory proteins referred to as inhibitor of NF-κB (IκB) proteins, which prevent NF-κB nuclear translocation and DNA binding [19].
T335 2821-3049 Sentence denotes Finally, recent discoveries revealing a genetic association with several genes relevant to NF-κB signalling, including CD40, TRAF1, TNFAIP3, and c-REL, further highlight the importance of NF-κB activation in RA pathogenesis [8].
T334 2698-2820 Sentence denotes Defects in the regulation of osteoclastogenesis are the major cause of bone erosion in osteolytic diseases such as RA [7].
T333 2518-2697 Sentence denotes Next to its role in proinflammatory gene expression, NF-κB is also essential for osteoclastogenesis, mainly by mediating the effects of receptor activator of NF-κB ligand (RANKL).
T332 2366-2517 Sentence denotes The time course of NF-κB activation appears to precede the onset of disease, and blockade of NF-κB by different means decreases disease severity [5,6].
T331 2116-2365 Sentence denotes NF-κB activation can be detected in cultured synovial fibroblasts and synovial tissue from RA patients, and animal models of inflammatory arthritis also demonstrate the active role of NF-κB in the development and progression of RA (reviewed in [4]).
T330 2022-2115 Sentence denotes In addition, TNF and IL-1 are themselves very potent activators of NF-κB (reviewed in [2,3]).
T329 1618-2021 Sentence denotes NF-κB represents a family of structurally related and evolutionarily conserved proteins (p100 or NF-κB2, p105 or NF-κB1, p65 or RelA, RelB, c-Rel) that function as homodimers or heterodimers [1], and that regulate the expression of a large number of genes - such as TNF, IL-1, IL-6, cyclo-oxygenase-2, chemokines, inducible nitric oxide synthase, and matrix metalloproteinases - that are involved in RA.
T328 1420-1617 Sentence denotes The aetiology of RA is still not understood, but it is well accepted that activation of NF-κB-dependent gene expression plays a key role in the development of RA and many other autoimmune diseases.
T327 1272-1419 Sentence denotes Proliferation of synovial fibroblasts leads to the formation of pannus tissue, which invades and degrades articular cartilage and subchondral bone.
T326 1005-1271 Sentence denotes Infiltration of cells of the innate and adaptive immune system into the joint space drives the local production of proinflammatory T-helper type 1 and T-helper type 17 cytokines, chemokines, and matrix metalloproteinases by infiltrating monocytes and synovial cells.
T325 800-1004 Sentence denotes RA is characterised by a symmetrical polyarthritis in which chronic inflammation of joints is associated with a progressive destruction of cartilage and bone, leading to functional decline and disability.
T324 687-799 Sentence denotes Rheumatoid arthritis (RA) is the most common inflammatory arthritis, affecting up to 1% of the adult population.
T18902 33402-33651 Sentence denotes How all these regulatory signals are themselves regulated will be an important question in order to clarify how NF-κB signalling is organised, and, more importantly, how this knowledge may lead to new treatments for inflammatory diseases such as RA.
T18901 33280-33401 Sentence denotes In addition, given the number of miRNAs in humans and the multiple mRNAs they target, intense complexity can be expected.
T18900 33071-33279 Sentence denotes The existence of multiple negative regulators ensuring a tight regulation of the NF-κB pathway, however, raises the question of the specific role of each of these regulators and the relationship between them.
T18899 32964-33070 Sentence denotes Keeping NF-κB activation under control can thus be very important for the design of specific therapeutics.
T18898 32823-32963 Sentence denotes The NF-κB family of transcription factors plays crucial roles in the inflammatory processes in RA leading to cartilage and bone destruction.
T1772 6825-6985 Sentence denotes Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA.
T1771 6614-6824 Sentence denotes Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]).
T1770 6311-6613 Sentence denotes Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18].
T1769 6138-6310 Sentence denotes HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16].
T1768 5880-6137 Sentence denotes High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology.
T1767 5695-5879 Sentence denotes Moreover, animal models using TLR knockout mice or strategies to block TLR signalling clearly identify TLR-dependent inflammation as being important in the pathogenesis of the disease.
T1766 5567-5694 Sentence denotes TLRs are expressed in RA synovial tissues and various endogenous ligands are present within the inflamed joints of RA patients.
T1765 5316-5566 Sentence denotes In addition to microbial ligands, an increasing number of endogenous ligands - a group of proteins derived from host tissues and cells - have been reported as candidate activators of TLRs inducing so-called sterile inflammation (reviewed in [14,15]).
T1764 5154-5315 Sentence denotes Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases and are potential candidates for inducing NF-κB-dependent inflammation in RA.
T1763 5002-5153 Sentence denotes Finally, lymphotoxin β receptor signalling has been implicated in tertiary lymphoid organ formation at sites of chronic inflammation including RA [13].
T1762 4756-5001 Sentence denotes Enhanced expression of the TNF receptor family member B-cell activating factor (BAFF), allowing the survival of autoantibody- producing B lymphocytes, is also characteristic for RA, and antagonists of BAFF have been developed to counter RA [13].
T1761 4479-4755 Sentence denotes However, studies with antagonistic anti-CD40 or anti-CD154 antibodies led to the conclusion that CD40 signals may be important at the initial stages of arthritis induction, but are not required once disease is established and pathogenic antibodies are already present [11,12].
T1760 4207-4478 Sentence denotes Binding of the CD40 ligand (CD154), which is transiently expressed on the surface of activated CD4+ T cells, triggers NF-κB activation resulting in fibroblast proliferation and secretion of proinflammatory cytokines and chemokines, which contributes to joint destruction.
T1759 3903-4206 Sentence denotes CD40 is another TNF receptor family member that is functionally expressed on a variety of cell types, including smooth muscle fibroblasts from normal and RA patients and RA synovial cells, B cells, macrophages, and dendritic cells, and can be upregulated by proinflammatory cytokines including TNF [10].
T1 0-72 Sentence denotes Negative regulation of NF-κB and its involvement in rheumatoid arthritis
T2 83-317 Sentence denotes The transcription factor NF-κB plays crucial roles in the regulation of inflammation and mmune responses, and inappropriate NF-κB activity has been linked with many autoimmune and inflammatory diseases, including rheumatoid arthritis.
T3 318-491 Sentence denotes Cells employ a multilayered control system to keep NF-κB signalling in check, including a repertoire of negative feedback regulators ensuring termination of NF-κB responses.
T4 492-672 Sentence denotes Here we will review various negative regulatory mechanisms that have evolved to control NF-κB signalling and which have been implicated in the pathogenesis of rheumatoid arthritis.
T1 0-72 Sentence denotes Negative regulation of NF-κB and its involvement in rheumatoid arthritis
T2 74-82 Sentence denotes Abstract
T3 83-317 Sentence denotes The transcription factor NF-κB plays crucial roles in the regulation of inflammation and mmune responses, and inappropriate NF-κB activity has been linked with many autoimmune and inflammatory diseases, including rheumatoid arthritis.
T4 318-491 Sentence denotes Cells employ a multilayered control system to keep NF-κB signalling in check, including a repertoire of negative feedback regulators ensuring termination of NF-κB responses.
T5 492-672 Sentence denotes Here we will review various negative regulatory mechanisms that have evolved to control NF-κB signalling and which have been implicated in the pathogenesis of rheumatoid arthritis.
T6 674-686 Sentence denotes Introduction
T7 687-799 Sentence denotes Rheumatoid arthritis (RA) is the most common inflammatory arthritis, affecting up to 1% of the adult population.
T8 800-1004 Sentence denotes RA is characterised by a symmetrical polyarthritis in which chronic inflammation of joints is associated with a progressive destruction of cartilage and bone, leading to functional decline and disability.
T9 1005-1271 Sentence denotes Infiltration of cells of the innate and adaptive immune system into the joint space drives the local production of proinflammatory T-helper type 1 and T-helper type 17 cytokines, chemokines, and matrix metalloproteinases by infiltrating monocytes and synovial cells.
T10 1272-1419 Sentence denotes Proliferation of synovial fibroblasts leads to the formation of pannus tissue, which invades and degrades articular cartilage and subchondral bone.
T11 1420-1617 Sentence denotes The aetiology of RA is still not understood, but it is well accepted that activation of NF-κB-dependent gene expression plays a key role in the development of RA and many other autoimmune diseases.
T12 1618-2021 Sentence denotes NF-κB represents a family of structurally related and evolutionarily conserved proteins (p100 or NF-κB2, p105 or NF-κB1, p65 or RelA, RelB, c-Rel) that function as homodimers or heterodimers [1], and that regulate the expression of a large number of genes - such as TNF, IL-1, IL-6, cyclo-oxygenase-2, chemokines, inducible nitric oxide synthase, and matrix metalloproteinases - that are involved in RA.
T13 2022-2115 Sentence denotes In addition, TNF and IL-1 are themselves very potent activators of NF-κB (reviewed in [2,3]).
T14 2116-2365 Sentence denotes NF-κB activation can be detected in cultured synovial fibroblasts and synovial tissue from RA patients, and animal models of inflammatory arthritis also demonstrate the active role of NF-κB in the development and progression of RA (reviewed in [4]).
T15 2366-2517 Sentence denotes The time course of NF-κB activation appears to precede the onset of disease, and blockade of NF-κB by different means decreases disease severity [5,6].
T16 2518-2697 Sentence denotes Next to its role in proinflammatory gene expression, NF-κB is also essential for osteoclastogenesis, mainly by mediating the effects of receptor activator of NF-κB ligand (RANKL).
T17 2698-2820 Sentence denotes Defects in the regulation of osteoclastogenesis are the major cause of bone erosion in osteolytic diseases such as RA [7].
T18 2821-3049 Sentence denotes Finally, recent discoveries revealing a genetic association with several genes relevant to NF-κB signalling, including CD40, TRAF1, TNFAIP3, and c-REL, further highlight the importance of NF-κB activation in RA pathogenesis [8].
T19 3051-3098 Sentence denotes Pathological triggers of NF-κB signalling in RA
T20 3099-3256 Sentence denotes Since NF-κB is central to the process of inflammation in RA, much research deals with the identification of the molecular triggers that activate NF-κB in RA.
T21 3257-3449 Sentence denotes It is well accepted that proinflammatory cytokines such as TNF and IL-1 play an important role, and administration of TNF antagonists is an effective treatment for severe RA (reviewed in [9]).
T22 3450-3643 Sentence denotes TNF and IL-1 are both very potent activators of NF-κB and it can be expected that NF-κB activation by these cytokines mediates most of their pro-inflammatory activities in RA (reviewed in [3]).
T23 3644-3902 Sentence denotes NF-κB activation by receptor activator of NF-κB (RANK), a TNF receptor family member, is important for osteoclastogenesis, and defects in proper RANK-NF-κB signalling are likely to be involved in RA pathology and other diseases associated with bone loss [7].
T24 3903-4206 Sentence denotes CD40 is another TNF receptor family member that is functionally expressed on a variety of cell types, including smooth muscle fibroblasts from normal and RA patients and RA synovial cells, B cells, macrophages, and dendritic cells, and can be upregulated by proinflammatory cytokines including TNF [10].
T25 4207-4478 Sentence denotes Binding of the CD40 ligand (CD154), which is transiently expressed on the surface of activated CD4+ T cells, triggers NF-κB activation resulting in fibroblast proliferation and secretion of proinflammatory cytokines and chemokines, which contributes to joint destruction.
T26 4479-4755 Sentence denotes However, studies with antagonistic anti-CD40 or anti-CD154 antibodies led to the conclusion that CD40 signals may be important at the initial stages of arthritis induction, but are not required once disease is established and pathogenic antibodies are already present [11,12].
T27 4756-5001 Sentence denotes Enhanced expression of the TNF receptor family member B-cell activating factor (BAFF), allowing the survival of autoantibody- producing B lymphocytes, is also characteristic for RA, and antagonists of BAFF have been developed to counter RA [13].
T28 5002-5153 Sentence denotes Finally, lymphotoxin β receptor signalling has been implicated in tertiary lymphoid organ formation at sites of chronic inflammation including RA [13].
T29 5154-5315 Sentence denotes Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases and are potential candidates for inducing NF-κB-dependent inflammation in RA.
T30 5316-5566 Sentence denotes In addition to microbial ligands, an increasing number of endogenous ligands - a group of proteins derived from host tissues and cells - have been reported as candidate activators of TLRs inducing so-called sterile inflammation (reviewed in [14,15]).
T31 5567-5694 Sentence denotes TLRs are expressed in RA synovial tissues and various endogenous ligands are present within the inflamed joints of RA patients.
T32 5695-5879 Sentence denotes Moreover, animal models using TLR knockout mice or strategies to block TLR signalling clearly identify TLR-dependent inflammation as being important in the pathogenesis of the disease.
T33 5880-6137 Sentence denotes High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology.
T34 6138-6310 Sentence denotes HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16].
T35 6311-6613 Sentence denotes Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18].
T36 6614-6824 Sentence denotes Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]).
T37 6825-6985 Sentence denotes Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA.
T38 6987-7023 Sentence denotes Basic principles of NF-κB signalling
T39 7024-7228 Sentence denotes NF-κB proteins are sequestered in the cytoplasm as latent complexes by inhibitory proteins referred to as inhibitor of NF-κB (IκB) proteins, which prevent NF-κB nuclear translocation and DNA binding [19].
T40 7229-7514 Sentence denotes Whereas the majority of IκBs (IκBα, IκBβ, IκBε, p105 (also known as NF-κB1), p100 (also known as NF-κB2)) serve as inhibitors of NF-κB, IκBξ and Bcl-3 instead potentiate NF-κB transactivation in the nucleus. p100 and p105 are precursors of the p52 and p50 NF-κB subunits, respectively.
T41 7515-7644 Sentence denotes There are two unique NF-κB signalling pathways, termed canonical (or classical) and noncanonical (or alternative) NF-κB pathways.
T42 7645-7853 Sentence denotes The canonical NF-κB pathway plays a major role in innate and adaptive immunity, and is triggered by many stimuli including proinflammatory cytokines (for example, TNF, IL-1), antigens, RANKL, and TLR ligands.
T43 7854-8215 Sentence denotes NF-κB signalling initiated by different receptors requires the formation of proximal protein-protein interactions that are often receptor specific, but ultimately converge in the activation of the IκB kinase (IKK) complex, which mediates phosphorylation of the inhibitory IκB protein leading to its K48-polyubiquitination and degradation by the proteasome [20].
T44 8216-8411 Sentence denotes The IKK complex is comprised of the two catalytic subunits IKK1 and IKK2 (also known as IKKα and IKKβ) and the regulatory subunit NF-κB essential modulator (NEMO - also known as IKKγ) (Figure 1).
T45 8412-8529 Sentence denotes Gene targeting experiments showed that IKK2 and NEMO, but not IKK1, are required for canonical NF-κB activation [21].
T46 8530-8591 Sentence denotes Figure 1 Canonical NF-κB signalling and negative regulators.
T47 8592-8949 Sentence denotes Ligand engagement of specific membrane receptors such as TNFR1, CD40, RANK, and TLR4 trigger the recruitment of specific adaptor proteins (TNF receptor 1-associated death domain protein (TRADD), MyD88, MAL, TIR domain-containing adaptor-inducing IFNβ (TRIF)), kinases (RIP1, IRAK1, IRAK4), and ubiquitin ligases (TRAF2, TRAF6, cIAP1, cIAP2) to the receptor.
T48 8950-9120 Sentence denotes K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1, is recognised by NEMO and TAB proteins, resulting in the recruitment and activation of respectively IKK2 and TAK1.
T49 9121-9270 Sentence denotes TAK1 then phosphorylates and activates IKK2, which in turn phosphorylates IκBα, triggering its K48-linked ubiquitination and proteasomal degradation.
T50 9271-9399 Sentence denotes This allows NF-κB (here shown as a heterodimer of p65 and p50) to translocate to the nucleus and promote target gene expression.
T51 9400-9533 Sentence denotes TRAF1, which has no ubiquitin ligase activity, can negatively regulate NF-κB activation, most probably by competing with other TRAFs.
T52 9534-9877 Sentence denotes A20 and CYLD are deubiquitinating enzymes that control NF-κB activation by targeting specific signalling proteins including RIP1 and TRAF6, to which they are recruited using specific ubiquitin-binding adaptor proteins such as ABIN-1 and p62. miR-146 is thought to negatively regulate TLR signalling by inhibiting expression of IRAK1 and TRAF6.
T53 9878-10037 Sentence denotes Finally, TLR signalling can also be inhibited by the transmembrane protein SIGIRR, which has been proposed to compete with TLR4 for binding to IRAK1 and TRAF6.
T54 10038-10193 Sentence denotes The expression of many of these negative regulatory molecules is NF-κB dependent, implicating them in the negative feedback regulation of NF-κB activation.
T55 10194-10724 Sentence denotes ABIN, A20-binding inhibitor of NF-κB; cIAP, cellular inhibitor of apoptosis; CYLD, cylindromatosis; IKK, IκB kinase; IκB, inhibitor of NF-κB; IRAK, IL-1R-associated kinase; MyD88, myeloid differentiation primary response gene 88; NEMO, NF-κB essential modulator; NF, nuclear factor; RANK, receptor activator of NF-κB; RIP1, receptor interacting protein 1; SIGIRR, single-immunoglobulinIL-1 receptor-related; TIR, Toll-like receptor/IL-1R; TRAF, TNF receptor-associated factor; TLR, Toll-like receptor; TNF, tumour necrosis factor.
T56 10725-10794 Sentence denotes One of the best studied NF-κB signalling pathways is the TNF pathway.
T57 10795-11163 Sentence denotes TNF stimulation results in the recruitment of TNF receptor-1-associated death domain (TRADD) protein and of receptor interacting protein 1 (RIP1), which function as adaptor proteins for the E3 ubiquitin ligases TNF receptor-associated factor (TRAF) 2 and TRAF5, which in turn bind the E3 ubiquitin ligases cellular inhibitor of apoptosis (cIAP) 1 and cIAP2 (Figure 1).
T58 11164-11263 Sentence denotes On TNF stimulation, TNF-receptor bound RIP1 is rapidly modified by K63-linked polyubiquitin chains.
T59 11264-11376 Sentence denotes TRAF2/5 and cIAP1/2 are good candidates for RIP1 ubiquitination, but the specific role of each is still unclear.
T60 11377-11545 Sentence denotes The polyubiquitin chains on RIP1 are believed to create a scaffold to recruit the IKK and TAK1 complex via the ubiquitin-binding proteins NEMO and TAB1/2, respectively.
T61 11546-11740 Sentence denotes The recent identification of a distinct E2/E3 enzyme complex that modifies NEMO with linear polyubiquitin chains and is essential for TNF-activated NF-κB signalling adds further complexity [22].
T62 11741-11924 Sentence denotes The exact role of protein-anchored polyubiquitin chains remains unclear, as it was recently suggested that unanchored polyubiquitin chains can directly activate the TAK1 complex [23].
T63 11925-11980 Sentence denotes Similar signalling principles apply to other receptors.
T64 11981-12346 Sentence denotes For example, TLR4 stimulation by lipopolysaccharide induces the recruitment of Toll/IL-1 receptor adaptor protein (also referred to as Mal) and TRIF-related adaptor molecule (TRAM), which most probably serve as bridging factors to recruit myeloid differentiation primary response gene 88 (MyD88) and TIR domain-containing adaptor-inducing IFNβ (TRIF), respectively.
T65 12347-12498 Sentence denotes MyD88 in turn recruits members of the IL-1R-associated kinase (IRAK) family and TRAF6, leading to oligomerisation and selfubiquitination of TRAF6 [24].
T66 12499-12568 Sentence denotes TRIF also recruits TRAF6 [25] and RIP1 [26] via a direct interaction.
T67 12569-12685 Sentence denotes Both pathways then activate TAK1 and IKK in a ubiquitination-dependent manner similar to the TNF pathway (Figure 1).
T68 12686-12806 Sentence denotes The noncanonical NF-κB pathway can be activated by the lymphotoxin β receptor, BAFF receptor, CD40, and RANK (Figure 2).
T69 12807-13184 Sentence denotes In this pathway, p100 is processed by the proteasome to p52, which together with the RelB NF-κB subunit regulates a distinct set of target genes that control B-cell development, secondary lymphoid organ development, and osteoclastogenesis [27] The noncanonical NF-κB pathway is strictly dependent on IKK1, which is activated upon phosphorylation by NF-κB inducing kinase (NIK).
T70 13185-13306 Sentence denotes NIK is predominantly regulated at the post-translational level and is present at extremely low levels in most cell types.
T71 13307-13487 Sentence denotes In unstimulated cells, NIK occurs in a cytoplasmic complex with TRAF2, TRAF3, and cIAP1/2, which K48-polyubiquitinates NIK, leading to its continuous degradation by the proteasome.
T72 13488-13690 Sentence denotes Receptor ligation has been shown not only to remove TRAF3 from this complex by recruiting it to the receptor, but also to attract TRAF2 and cIAP1/2, which are essential for subsequent TRAF3 degradation.
T73 13691-13838 Sentence denotes All this contributes to releasing NIK from its constitutive degradation, resulting in NIK accumulation and IKK1 phosphorylation [28,29] (Figure 2).
T74 13839-13879 Sentence denotes Figure 2 Noncanonical NF-κB signalling.
T75 13880-14005 Sentence denotes CD40 and RANK can activate the noncanonical NF-κB pathway that is dependent on NF-κB inducing kinase (NIK) expression levels.
T76 14006-14222 Sentence denotes In unstimulated cells NIK forms a cytosolic complex with the ubiquitin ligases TRAF2, TRAF3 and cIAP1/2, which facilitates the K48-linked polyubiquitination and proteasomal degradation of NIK, keeping NIK levels low.
T77 14223-14387 Sentence denotes Upon ligand binding, TRAF3 is recruited to the receptor, where TRAF2 directs nondegradative K63-linked polyubiquitination of cIAP1/2, resulting in their activation.
T78 14388-14477 Sentence denotes Subsequently cIAP1/2 directs its K48-linked polyubiquitination to TRAF3, rather than NIK.
T79 14478-14578 Sentence denotes As a result, TRAF3 is degraded and NIK is stabilised, resulting in increased NIK levels in the cell.
T80 14579-14665 Sentence denotes NIK then phosphorylates and activates IKK1, which mediates NF-κB p100 phosphorylation.
T81 14666-14830 Sentence denotes This is followed by K48-linked polyubiquitination and partial proteasomal degradation of p100 to p52, which forms a heterodimer with RelB to activate transcription.
T82 14831-15166 Sentence denotes Next to TRAF3, TRAF1 has also been identified as a negative regulator of this pathway, most probably by competing with other TNF receptor-associated factors. cIAP, cellular inhibitor of apoptosis; IKK, IκB kinase; NF, nuclear factor; RANK, receptor activator of NF-κB; TRAF, TNF receptor-associated factor; TNF, tumour necrosis factor.
T83 15167-15317 Sentence denotes It should be mentioned that CD40, lymphotoxin β receptor and RANK mediate the activation of both canonical and noncanonical NF-κB signalling pathways.
T84 15318-15606 Sentence denotes Upon binding of their ligand, CD40 and RANK interact with several TRAF members, including TRAF1, TRAF2, TRAF3, TRAF5, and TRAF6, and this leads to the proteolysis of both TRAF2 and TRAF3, which represents an important step in the activation of the noncanonical pathway as described above.
T85 15607-15700 Sentence denotes Specific TRAF molecules are associated with overlapping and distinct CD40-mediated functions.
T86 15701-15914 Sentence denotes For example, in B cells TRAF6 is required for CD40-mediated JNK activation and IL-6 production, while TRAF2 is required for activation of NF-κB, and TRAF3 serves as a negative regulator of CD40 signalling [30,31].
T87 15916-15961 Sentence denotes Negative regulation of NF-κB signalling in RA
T88 15962-16169 Sentence denotes Since NF-κB activation is so crucial to many cellular processes, a tight regulation of the NF-κB signalling pathway and the genes it induces is an absolute requirement to fine-tune the inflammatory response.
T89 16170-16321 Sentence denotes Moreover, terminating an NF-κB response is essential to prevent persistent NF-κB activation that may lead to chronic inflammation and/or tumorigenesis.
T90 16322-16462 Sentence denotes To achieve this, cells employ different mechanisms, including the expression of inhibitory proteins that downregulate NF-κB signalling [32].
T91 16463-16677 Sentence denotes Below we give an overview of a number of proteins that are involved in the dampening or termination of the NF-κB response, some of them under the control of NF-κB itself and thus acting in a negative feedback loop.
T92 16678-16784 Sentence denotes In addition, we discuss the potential role of these NF-κB inhibitory factors in the immunopathology of RA.
T93 16785-16962 Sentence denotes Several other proteins involved in the negative regulation of NF-κB-dependent inflammatory responses, such as MyD88s, IRAK-M, and TOLLIP, have been described (reviewed in [33]).
T94 16963-17059 Sentence denotes These proteins are not discussed here, since a link with RA pathology has not yet been reported.
T95 17060-17279 Sentence denotes Although IKK1 is a critical component of the non-canonical NF-κB pathway, it should be mentioned that this kinase also plays a prominent role in the negative regulation of both canonical and noncanonical NF-κB pathways.
T96 17280-17479 Sentence denotes Macrophages from IKK1-deficient mice or knockin mice expressing inactive IKK1 show increased production of proinflammatory cytokines as a result of enhanced IKK2 activation and IκBα degradation [34].
T97 17480-17607 Sentence denotes IKK1 has also been shown to inhibit nuclear NF-κB and to downregulate proinflammatory signalling by phosphorylating STAT1 [35].
T98 17608-17939 Sentence denotes Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback regulation of the noncanonical NF-κB pathway [36], supporting the idea that IKK1 plays important roles in terminating both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA.
T99 17941-17952 Sentence denotes A20 protein
T100 17953-18274 Sentence denotes A20 (also known as TNFAIP3) is a ubiquitin-editing protein that negatively regulates NF-κB-dependent gene expression in response to different immune-activating stimuli, including TNF, IL-1 and antigens, and the triggering of TLRs and the nucleotide-binding oligomerisation domain-containing 2 receptor (reviewed in [37]).
T101 18275-18483 Sentence denotes A20 is believed to inhibit NF-κB function by deubiquitinating specific NF-κB signalling molecules, such as RIP1, RIP2, TRAF6 and MALT1, which disrupts specific protein-protein interactions [38-41] (Figure 1).
T102 18484-18733 Sentence denotes Recently, the disruption of interactions between E2 ubiquitin conjugating enzymes (Ubc13 and Ubc5hc) and E3 ubiquitin ligases (TRAF6, TRAF2 and cIAP1/2) were described as another important mechanism used by A20 to downregulate NF-κB signalling [42].
T103 18734-18913 Sentence denotes The association of A20 with its targets requires specific ubiquitin-binding adaptor proteins, including A20-binding inhibitor of NF-κB (ABIN) 1 and Tax1-binding protein 1 [43-46].
T104 18914-19037 Sentence denotes Next to its role in suppressing NF-κB activation, A20 is also a strong inhibitor of apoptosis, at least in some cell types.
T105 19038-19125 Sentence denotes The mechanisms by which A20 regulates apoptotic signalling, however, are still elusive.
T106 19126-19310 Sentence denotes A20-deficient mice spontaneously develop multiorgan inflammation and cachexia and die within 2 weeks of birth, illustrating the potent anti-inflammatory function of this molecule [46].
T107 19311-19432 Sentence denotes A20-deficient cells are also more susceptible to TNF-mediated apoptosis, confirming its role as an antiapoptotic protein.
T108 19433-19748 Sentence denotes We recently showed that mice specifically lacking A20 in intestinal epithelial cells exhibit increased susceptibility to experimental colitis due to the hypersensitivity of their intestinal epithelial cells to TNF-induced apoptosis, confirming A20 as a major antiapoptotic protein in the intestinal epithelium [47].
T109 19749-19928 Sentence denotes Two independent studies showed that mice lacking A20 in B cells develop autoimmunity due to hyperactive NF-κB responses in B cells leading to unrestricted B-cell survival [48,49].
T110 19929-20090 Sentence denotes A20 expression has been observed in several cell types that play important roles in the pathophysiology of RA, such as fibroblasts, synoviocytes and lymphocytes.
T111 20091-20228 Sentence denotes Interestingly, A20 expression is itself regulated by NF-κB [50], implicating A20 in the negative feedback regulation of NF-κB signalling.
T112 20229-20498 Sentence denotes Recently, intra-articular injection of an A20-expressing adenovirus was shown to reduce the severity of synovial inflammation and joint destruction in a mouse model of collagen-induced arthritis, even in untreated joints, in both a prophylactic and therapeutic setting.
T113 20499-20852 Sentence denotes A20 expression in synovial tissue was associated with inhibition of NF-κB activity and decreased levels of TNF, IL-1β, IL-6, soluble RANKL, monocyte chemo-attractant protein 1, and IL-17, suggesting that A20 induces a protective effect in collagen-induced arthritis mice through suppression of NF-κB activation and NF- κB-dependent gene expression [51].
T114 20853-21127 Sentence denotes Because TNF and IL-1β are known to mediate synovitis, pannus formation, and erosion of cartilage and bone in RA, the decreased serum levels of TNF and IL-1β in A20-transduced mice might explain the beneficial effects in the clinical, pathological, and radiological findings.
T115 21128-21256 Sentence denotes This study also demonstrated that A20 overexpression leads to a decrease in the number of activated osteoclasts in joint tissue.
T116 21257-21358 Sentence denotes A20 might therefore minimise joint destruction through decreasing the osteoclast number and activity.
T117 21359-21567 Sentence denotes It will be interesting to analyse in future the susceptibility of conditional knockout mice that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells.
T118 21568-21728 Sentence denotes Importantly, several SNPs in the human A20 locus have been associated with increased susceptibility to development of autoimmune pathologies (reviewed in [52]).
T119 21729-21891 Sentence denotes Several genome-wide association studies also revealed a clear association between mutations in the A20 locus in the 6q23 chromosome and susceptibility to RA [52].
T120 21892-22112 Sentence denotes Although the identified variants are not located in a gene, they are thought to influence A20 as its nearest gene (~150 kb downstream of A20), probably by the presence of potential regulatory DNA elements in this region.
T121 22113-22293 Sentence denotes As A20 is required for termination of TNF-induced signals, and TNF is the primary inflammatory cytokine in RA, these findings reveal A20 as a candidate susceptibility locus for RA.
T122 22294-22387 Sentence denotes How these variants affect normal A20 activity and how they cause RA, however, remain unclear.
T123 22388-22612 Sentence denotes Recently, Elsby and colleagues functionally evaluated in vitro the regulatory ability of RA-associated SNP variants on A20 promoter activity, and could show repressed A20 transcription for some of the SNPs investigated [53].
T124 22613-22738 Sentence denotes It will be of interest to identify the actual causal variants and to elucidate the functional consequences of these variants.
T125 22739-22864 Sentence denotes In this context, knockin mice for the corresponding A20 SNPs, combined with mouse models for RA, will be very valuable tools.
T126 22866-22897 Sentence denotes A20-binding inhibitors of NF-κB
T127 22898-23143 Sentence denotes ABIN-1, ABIN-2 and ABIN-3 (also known as TNIP-1, TNIP-2, and TNIP-3) were identified as ubiquitously expressed A20 interacting proteins and were shown to inhibit NF-κB activation by TNF and several other inflammatory stimuli upon overexpression.
T128 23144-23280 Sentence denotes Because ABINs contain a specific ubiquitin-binding motif, they have been proposed to target A20 to polyubiquitinated substrates [43,44].
T129 23281-23475 Sentence denotes Similar to A20, ABIN-1 and ABIN-3 expression is NF-κB dependent, implicating a potential role for the A20/ABIN complex in the negative feedback regulation of NF-κB activation (reviewed in [54]).
T130 23476-23695 Sentence denotes Unexpectedly, both ABIN-1-deficient and ABIN-2-deficient mice exhibit only slightly increased or normal NF-κB responses, respectively, possibly reflecting redundant NF-κB inhibitory activities of multiple ABINs [55,56].
T131 23696-23840 Sentence denotes Functional ABIN-3 is expressed in humans, but mice only express a truncated and inactive form lacking the crucial ubiquitin-binding domain [57].
T132 23841-24004 Sentence denotes As for A20, ABIN-1 also strongly inhibits TNF-induced apoptosis [58], and ABIN-1 deficient mice die embryonically due to TNF-dependent foetal liver apoptosis [56].
T133 24005-24332 Sentence denotes Using oligonucleotide microarray analysis, ABIN-1 was identified among TNF-induced genes in human synoviocytes, and high levels of ABIN-1 mRNA were detected in RA tissue biopsies, indicating a potential role for ABIN-1, together with A20, in the negative feedback regulation of NF-κB signalling and the pathogenesis of RA [59].
T134 24333-24541 Sentence denotes In a recent study, inhibition of TLR responses by immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptors was shown to depend on the expression of the NF-κB inhibitory proteins ABIN-3 and A20.
T135 24542-24663 Sentence denotes Moreover, this protective effect of the ITAM was strongly suppressed in inflammatory arthritis synovial macrophages [60].
T136 24664-24787 Sentence denotes Interestingly, ABIN-1 polymorphisms have been associated with psoriasis and systemic lupus erythematosus in humans [61,62].
T137 24788-25071 Sentence denotes A high degree of overlap between systemic lupus erythematosus and RA susceptibility loci might be expected as the two diseases show some clinical overlap in joint involvement, autoantibody production, systemic features and response to treatments such as B-cell depletion (rituximab).
T138 25072-25236 Sentence denotes It will therefore be interesting to investigate whether SNPs that have been reported to be associated with systemic lupus erythematosus are also associated with RA.
T139 25238-25261 Sentence denotes Cylindromatosis protein
T140 25262-25384 Sentence denotes Cylindromatosis (CYLD) protein was originally identified as a tumour suppressor involved in familial cylindromatosis [63].
T141 25385-25577 Sentence denotes CYLD is also involved, however, in diverse physiological processes ranging from immunity and inflammation to cell cycle progression, spermatogenesis, and osteoclastogenesis (reviewed in [64]).
T142 25578-25848 Sentence denotes CYLD is a deubiquitinating enzyme that negatively regulates NF-κB signalling initiated by TNFR, RANK and T-cell receptor stimulation (reviewed in [64]) (Figure 1), by deubiquitina-ting several NF-κB signalling proteins including NEMO, TRAF2, TRAF6, TRAF7, RIP1 and TAK1.
T143 25849-25981 Sentence denotes Many of these are also targeted by A20 and it is still not clear why the cell needs A20 as well as CYLD to control NF-κB activation.
T144 25982-26197 Sentence denotes As A20 is only expressed in many cell types upon stimulation, it has been suggested that this protein mainly regulates later phases of NF-κB signalling, whereas CYLD would regulate constitutive and early signalling.
T145 26198-26274 Sentence denotes In addition, their relative activity might also be cell-type dependent [64].
T146 26275-26385 Sentence denotes Interestingly, CYLD has been shown to negatively regulate RANK signalling and osteoclastogenesis in mice [65].
T147 26386-26498 Sentence denotes Mice with a genetic deficiency of CYLD have aberrant osteoclast differentiation and develop severe osteoporosis.
T148 26499-26629 Sentence denotes Osteoclast precursors of these mice are hyper-responsive to RANKL-induced differentiation and produce more and larger osteoclasts.
T149 26630-26902 Sentence denotes CYLD expression is markedly upregulated under conditions of RANKL-induced osteoclastogenesis and is recruited to ubiquitinated TRAF6 via the ubiquitin-binding adaptor protein p62 (also known as sequestosome 1) [65], followed by the CYLD-mediated deubiquitination of TRAF6.
T150 26903-27077 Sentence denotes In this context, it is worth mentioning that transgenic mice expressing a mutated form of p62 also display abnormal osteoclastogenesis and develop progressive bone loss [66].
T151 27078-27334 Sentence denotes These findings suggest that CYLD-mediated inhibi-tion of RANK-induced NF-κB signalling plays a key role in the negative regulation of osteoclastogenesis and indicate CYLD as a potential genetic factor involved in the pathology of bone disorders such as RA.
T152 27336-27387 Sentence denotes Single-immunoglobulin IL-1 receptor-related protein
T153 27388-27688 Sentence denotes Single-immunoglobulin IL-1 receptor-related (SIGIRR) protein, also known as TIR-8, is a member of the TLR/IL-1R family that has been extensively characterised as an inhibitor of IL-1R and TLR signalling, probably through direct interaction with these receptors, MyD88, IRAK1 or TRAF6 [67] (Figure 1).
T154 27689-27842 Sentence denotes Given the important role of IL-1R and TLR signalling in the chronic inflammation observed in RA [68], a regulatory role for SIGIRR in RA is not unlikely.
T155 27843-28008 Sentence denotes SIGIRR has a very restricted expression pattern, being expressed in epithelial cells, monocytes and immature dendritic cells, but not in mature macro-phages [69,70].
T156 28009-28139 Sentence denotes Recently, SIGIRR overexpression was shown to inhibit the spontaneous release of inflammatory cytokines by human RA synovial cells.
T157 28140-28352 Sentence denotes This inhibitory function of SIGIRR was further confirmed in vivo, since SIGIRR-deficient mice developed a more severe disease in zymosan-induced arthritis, as well as collagen-induced arthritis mouse models [70].
T158 28353-28547 Sentence denotes It will be interesting to compare the expression of SIGIRR in RA patients with its expression in control patients, or to investigate whether the function of SIGIRR is compromised in RA patients.
T159 28548-28653 Sentence denotes Because of its restricted expression pattern, SIGIRR may also be an interesting therapeutic target in RA.
T160 28655-28687 Sentence denotes TNF receptor-associated factor 1
T161 28688-28824 Sentence denotes TRAF1 is a unique member of the TRAF protein family because it lacks a RING finger domain and therefore lacks ubiquitin ligase activity.
T162 28825-29014 Sentence denotes Accumulating data support a role for TRAF1 as both a negative and a positive modulator of NF-κB signalling by certain TNF family receptors, possibly in a cell-type-dependent manner [71,72].
T163 29015-29121 Sentence denotes Expression of TRAF1 is inducible by TNF and overexpression of TRAF1 inhibits TNF-induced NF-κB activation.
T164 29122-29250 Sentence denotes TRAF1-deficient T cells are hyper-responsive to TNF, with enhanced proliferation and activation of the NF-κB signalling pathway.
T165 29251-29329 Sentence denotes TRAF1 also functions as a negative regulator of CD40-induced NF-κB activation.
T166 29330-29504 Sentence denotes TRAF1-deficient dendritic cells, however, show attenuated responses to secondary stimulation by TRAF2-dependent factors, suggesting a positive regulatory role in these cells.
T167 29505-29579 Sentence denotes The mechanism by which TRAF1 modulates NF- κB activation is still unclear.
T168 29580-29692 Sentence denotes Most probably, TRAF1 competes with TRAF family members for binding to the receptor or other signalling proteins.
T169 29693-29775 Sentence denotes Alternatively, TRAF1 might recruit A20 with which it can physically interact [73].
T170 29776-30025 Sentence denotes A genome-wide association study examining more than 300,000 SNPs among approximately 1,500 autoantibody-positive RA cases and 1,800 controls identified a genetic variation at the TRAF1-complement component 5 locus as an important RA risk locus [74].
T171 30026-30109 Sentence denotes Subsequent work indicates that TRAF1 is more likely to be the causative locus [75].
T172 30110-30216 Sentence denotes Recent work in a Korean population also demonstrates genetic association of the TRAF1 region with RA [76].
T173 30218-30227 Sentence denotes microRNAs
T174 30228-30438 Sentence denotes miRNAs are recently discovered regulators of gene expression and represent a class of noncoding RNA molecules essential in many cellular and developmental processes, including immune responses and inflammation.
T175 30439-30574 Sentence denotes They bind the 3'-UTR of target mRNAs leading to the repression of protein expression and the promotion of target mRNA degradation [77].
T176 30575-30757 Sentence denotes miR-146a/b and miR-155 are of particular interest for inflammatory signalling to NF-κB, since these miRNAs can be induced by inflammatory stimuli such as IL-1β, TNF and TLRs [78,79].
T177 30758-30919 Sentence denotes In addition, miR-146a is an NF-κB-dependent gene, and the NF-κB signalling molecules IRAK1 and TRAF6 were identified as target genes of miR-146a [78] (Figure 1).
T178 30920-31028 Sentence denotes Similarly, miR-155 was shown to target transcripts for the NF-κB signalling molecules IKKε and RIP1 [79,80].
T179 31029-31312 Sentence denotes Notably, both miR-146 and miR-155 are expressed at higher levels in RA synovial fibroblasts and synovial tissue [81,82], as well as in peripheral blood mononuclear cells of RA patients [83]. miR-146a is also overexpressed in CD4+ and IL-17-producing T cells from RA patients [84,85].
T180 31313-31640 Sentence denotes Interestingly, a polymorphism in the 3'-UTR of the miR-146a target gene was recently shown to be associated with RA susceptibility [86]. miR-155 overexpression in synovial fibroblasts was able to prevent the TLR and cytokine-inducible expression of specific matrix metalloproteinases that mediate tissue destruction in RA [81].
T181 31641-31904 Sentence denotes Moreover, miR-155 was shown to promote TNF production, a key process in the pathogenesis of RA [87]. miR-146 and miR-155 may therefore be important negative regulators of inflammation in RA and their potential for the development of new treatments is substantial.
T182 31905-32131 Sentence denotes In addition, their increased expression in RA patients is potentially useful as a marker for disease diagnosis, progression, or treatment efficacy [88], but this will require confirmation using a large and well-defined cohort.
T183 32132-32306 Sentence denotes Besides miR-146 and miR-155, a number of other miRNAs with a potential role in the control of NF-κB-dependent inflammatory responses in RA pathology were recently identified.
T184 32307-32469 Sentence denotes In this context, miR-124a - a key regulator of the chemokine monocyte chemoattractant protein 1 - was shown to be decreased in synoviocytes from RA patients [89].
T185 32470-32628 Sentence denotes Similarly, elevated levels of miR-203 - leading to increased secretion of matrix metalloproteinase-1 and IL-6 - were detected in RA synovial fibroblasts [90].
T186 32629-32809 Sentence denotes Finally, miR-16, miR-132, and miR-223 were also shown to have an altered expression in RA patients, indicating their potential as diagnostic biomarkers for pathogenesis [83,88,91].
T187 32811-32822 Sentence denotes Conclusions
T188 32823-32963 Sentence denotes The NF-κB family of transcription factors plays crucial roles in the inflammatory processes in RA leading to cartilage and bone destruction.
T189 32964-33070 Sentence denotes Keeping NF-κB activation under control can thus be very important for the design of specific therapeutics.
T190 33071-33279 Sentence denotes The existence of multiple negative regulators ensuring a tight regulation of the NF-κB pathway, however, raises the question of the specific role of each of these regulators and the relationship between them.
T191 33280-33401 Sentence denotes In addition, given the number of miRNAs in humans and the multiple mRNAs they target, intense complexity can be expected.
T192 33402-33651 Sentence denotes How all these regulatory signals are themselves regulated will be an important question in order to clarify how NF-κB signalling is organised, and, more importantly, how this knowledge may lead to new treatments for inflammatory diseases such as RA.
T193 33653-33666 Sentence denotes Abbreviations
T194 33667-34405 Sentence denotes ABIN: A20-binding inhibitor of NF-κB; BAFF: B-cell activating factor; cIAP: cellular inhibitor of apoptosis; CYLD: cylindromatosis; HMGB1: high mobility group box chromosomal protein 1; IFN: interferon; IKK: IκB kinase; IκB: inhibitor of NF-κB; IL: interleukin; IRAK: IL-1R-associated kinase; ITAM: immunoreceptor tyrosine-based activation motif; miRNA: microRNA; MyD88: myeloid differentiation primary response gene 88; NEMO: NF-κB essential modulator; NF: nuclear factor; NIK: NF-κB inducing kinase; RA: rheumatoid arthritis; RANK: receptor activator of NF-κB; RANKL: receptor activator of NF-κB ligand; RIP1: receptor interacting protein 1; SIGIRR: single-immunoglobulin IL-1 receptor-related; SNP: single nucleotide polymorphism; TIR:
T195 34406-34474 Sentence denotes Toll-like receptor/IL-1R; TRAF: TNF receptor-associated factor; TLR:
T196 34475-34600 Sentence denotes Toll-like receptor; TNF: tumour necrosis factor; TRIF: TIR domain-containing adaptor-inducing IFNβ; UTR: untranslated region.
T197 34602-34621 Sentence denotes Competing interests
T198 34622-34680 Sentence denotes The authors declare that they have no competing interests.

ICD10

Id Subject Object Predicate Lexical cue
T15774 28324-28333 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis
T15773 28285-28294 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis
T14595 27308-27322 http://purl.bioontology.org/ontology/ICD10/M89.9 denotes bone disorders
T14594 26485-26497 http://purl.bioontology.org/ontology/ICD10/M81.9 denotes osteoporosis
T13143 25188-25207 http://purl.bioontology.org/ontology/ICD10/L93 denotes lupus erythematosus
T13142 24830-24849 http://purl.bioontology.org/ontology/ICD10/L93 denotes lupus erythematosus
T13141 24749-24768 http://purl.bioontology.org/ontology/ICD10/L93 denotes lupus erythematosus
T10726 20755-20764 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis
T10725 20414-20423 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis
T10724 19195-19203 http://purl.bioontology.org/ontology/ICD10/R64 denotes cachexia
T2515 6287-6296 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis
T2514 4631-4640 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis
T803 837-850 http://purl.bioontology.org/ontology/ICD10/M13.0 denotes polyarthritis
T13140 25179-25207 http://purl.bioontology.org/ontology/ICD10/M32 denotes systemic lupus erythematosus
T13139 24821-24849 http://purl.bioontology.org/ontology/ICD10/M32 denotes systemic lupus erythematosus
T13138 24740-24768 http://purl.bioontology.org/ontology/ICD10/M32 denotes systemic lupus erythematosus
T13137 25179-25207 http://purl.bioontology.org/ontology/ICD10/M32.9 denotes systemic lupus erythematosus
T13136 24821-24849 http://purl.bioontology.org/ontology/ICD10/M32.9 denotes systemic lupus erythematosus
T13135 24740-24768 http://purl.bioontology.org/ontology/ICD10/M32.9 denotes systemic lupus erythematosus
T13134 24726-24735 http://purl.bioontology.org/ontology/ICD10/L40.9 denotes psoriasis
T13133 24726-24735 http://purl.bioontology.org/ontology/ICD10/L40 denotes psoriasis
T13132 24627-24636 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis
T802 2254-2263 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis
T801 745-754 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis
T800 698-707 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis
T799 687-707 http://purl.bioontology.org/ontology/ICD10/M06.9 denotes Rheumatoid arthritis
T109 296-316 http://purl.bioontology.org/ontology/ICD10/M06.9 denotes rheumatoid arthritis
T110 651-671 http://purl.bioontology.org/ontology/ICD10/M06.9 denotes rheumatoid arthritis
T112 307-316 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis
T113 662-671 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis
T108 52-72 http://purl.bioontology.org/ontology/ICD10/M06.9 denotes rheumatoid arthritis
T111 63-72 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis

simple1

Id Subject Object Predicate Lexical cue
T21825 14085-14090 Protein denotes TRAF2
T21824 14028-14031 Protein denotes NIK
T21823 13982-13985 Protein denotes NIK
T21822 13959-13980 Protein denotes NF-κB inducing kinase
T21821 13889-13893 Protein denotes RANK
T21820 13880-13884 Protein denotes CD40
T21853 15143-15165 Protein denotes tumour necrosis factor
T21852 15138-15141 Protein denotes TNF
T21851 15071-15098 Protein denotes receptor activator of NF-κB
T21850 15065-15069 Protein denotes RANK
T21849 14846-14851 Protein denotes TRAF1
T21848 14839-14844 Protein denotes TRAF3
T21847 14799-14803 Protein denotes RelB
T21846 14763-14766 Protein denotes p52
T21845 14755-14759 Protein denotes p100
T21844 14644-14648 Protein denotes p100
T21843 14617-14621 Protein denotes IKK1
T21842 14579-14582 Protein denotes NIK
T21841 14555-14558 Protein denotes NIK
T21840 14513-14516 Protein denotes NIK
T21839 14491-14496 Protein denotes TRAF3
T21838 14473-14476 Protein denotes NIK
T21837 14454-14459 Protein denotes TRAF3
T21836 14407-14408 Protein denotes 2
T21835 14401-14406 Protein denotes cIAP1
T21834 14354-14355 Protein denotes 2
T21833 14348-14353 Protein denotes cIAP1
T21832 14286-14291 Protein denotes TRAF2
T21831 14244-14249 Protein denotes TRAF3
T21830 14207-14210 Protein denotes NIK
T21829 14194-14197 Protein denotes NIK
T21828 14108-14109 Protein denotes 2
T21827 14102-14107 Protein denotes cIAP1
T21826 14092-14097 Protein denotes TRAF3
T20178 10701-10723 Protein denotes tumour necrosis factor
T20177 10696-10699 Protein denotes TNF
T20176 10558-10600 Protein denotes single-immunoglobulinIL-1 receptor-related
T20175 10550-10556 Protein denotes SIGIRR
T20174 10518-10548 Protein denotes receptor interacting protein 1
T20173 10512-10516 Protein denotes RIP1
T20172 10483-10510 Protein denotes receptor activator of NF-κB
T20171 10477-10481 Protein denotes RANK
T20170 10430-10455 Protein denotes NF-κB essential modulator
T20169 10424-10428 Protein denotes NEMO
T20168 10374-10422 Protein denotes myeloid differentiation primary response gene 88
T20167 10367-10372 Protein denotes MyD88
T20166 10277-10292 Protein denotes cylindromatosis
T20165 10271-10275 Protein denotes CYLD
T20164 10200-10230 Protein denotes A20-binding inhibitor of NF-κB
T20163 10194-10198 Protein denotes ABIN
T20162 10031-10036 Protein denotes TRAF6
T20161 10021-10026 Protein denotes IRAK1
T20160 10001-10005 Protein denotes TLR4
T20159 9953-9959 Protein denotes SIGIRR
T20158 9871-9876 Protein denotes TRAF6
T20157 9861-9866 Protein denotes IRAK1
T20156 9771-9774 Protein denotes p62
T20155 9760-9766 Protein denotes ABIN-1
T20154 9667-9672 Protein denotes TRAF6
T20153 9658-9662 Protein denotes RIP1
T20152 9542-9546 Protein denotes CYLD
T20151 9534-9537 Protein denotes A20
T20150 9400-9405 Protein denotes TRAF1
T20149 9329-9332 Protein denotes p50
T20148 9321-9324 Protein denotes p65
T20147 9195-9199 Protein denotes IκBα
T20146 9160-9164 Protein denotes IKK2
T20145 9121-9125 Protein denotes TAK1
T20144 9115-9119 Protein denotes TAK1
T20143 9106-9110 Protein denotes IKK2
T20142 9023-9027 Protein denotes NEMO
T20141 8999-9004 Protein denotes IRAK1
T20140 8990-8994 Protein denotes RIP1
T20139 8926-8931 Protein denotes cIAP2
T20138 8919-8924 Protein denotes cIAP1
T20137 8912-8917 Protein denotes TRAF6
T20136 8905-8910 Protein denotes TRAF2
T20135 8874-8879 Protein denotes IRAK4
T20134 8867-8872 Protein denotes IRAK1
T20133 8861-8865 Protein denotes RIP1
T20132 8844-8848 Protein denotes TRIF
T20131 8799-8842 Protein denotes TIR domain-containing adaptor-inducing IFNβ
T20130 8794-8797 Protein denotes MAL
T20129 8787-8792 Protein denotes MyD88
T20128 8779-8784 Protein denotes TRADD
T20127 8731-8777 Protein denotes TNF receptor 1-associated death domain protein
T20126 8672-8676 Protein denotes TLR4
T20125 8662-8666 Protein denotes RANK
T20124 8656-8660 Protein denotes CD40
T20123 8649-8654 Protein denotes TNFR1
T18038 32659-32666 Protein denotes miR-223
T18037 32646-32653 Protein denotes miR-132
T18036 32638-32644 Protein denotes miR-16
T18035 32575-32579 Protein denotes IL-6
T18034 32544-32570 Protein denotes matrix metalloproteinase-1
T18033 32500-32507 Protein denotes miR-203
T18032 32368-32402 Protein denotes monocyte chemoattractant protein 1
T18031 32324-32332 Protein denotes miR-124a
T18030 32152-32159 Protein denotes miR-155
T18029 31754-31761 Protein denotes miR-155
T18028 31680-31683 Protein denotes TNF
T18027 31651-31658 Protein denotes miR-155
T18026 31450-31457 Protein denotes miR-155
T18025 31364-31372 Protein denotes miR-146a
T18024 31263-31268 Protein denotes IL-17
T18023 31254-31257 Protein denotes CD4
T18022 31220-31228 Protein denotes miR-146a
T18021 31055-31062 Protein denotes miR-155
T18020 31015-31019 Protein denotes RIP1
T18019 31006-31010 Protein denotes IKKε
T18018 30931-30938 Protein denotes miR-155
T18017 30894-30902 Protein denotes miR-146a
T18016 30853-30858 Protein denotes TRAF6
T18015 30843-30848 Protein denotes IRAK1
T18014 30771-30779 Protein denotes miR-146a
T18013 30736-30739 Protein denotes TNF
T18012 30729-30734 Protein denotes IL-1β
T18011 30590-30597 Protein denotes miR-155
T18010 30584-30585 Protein denotes b
T18009 30575-30583 Protein denotes miR-146a
T16745 30190-30195 Protein denotes TRAF1
T16744 30057-30062 Protein denotes TRAF1
T16743 29955-29960 Protein denotes TRAF1
T16742 29728-29731 Protein denotes A20
T16741 29708-29713 Protein denotes TRAF1
T16740 29595-29600 Protein denotes TRAF1
T16739 29528-29533 Protein denotes TRAF1
T16738 29426-29431 Protein denotes TRAF2
T16737 29330-29335 Protein denotes TRAF1
T16736 29299-29303 Protein denotes CD40
T16735 29251-29256 Protein denotes TRAF1
T16734 29170-29173 Protein denotes TNF
T16733 29122-29127 Protein denotes TRAF1
T16732 29092-29095 Protein denotes TNF
T16731 29077-29082 Protein denotes TRAF1
T16730 29051-29054 Protein denotes TNF
T16729 29029-29034 Protein denotes TRAF1
T16728 28862-28867 Protein denotes TRAF1
T16727 28798-28807 Protein denotes ubiquitin
T16726 28688-28693 Protein denotes TRAF1
T16725 28655-28687 Protein denotes TNF receptor-associated factor 1
T15829 28594-28600 Protein denotes SIGIRR
T15828 28510-28516 Protein denotes SIGIRR
T15827 28405-28411 Protein denotes SIGIRR
T15826 28212-28218 Protein denotes SIGIRR
T15825 28168-28174 Protein denotes SIGIRR
T15824 28019-28025 Protein denotes SIGIRR
T15823 27843-27849 Protein denotes SIGIRR
T15822 27813-27819 Protein denotes SIGIRR
T15821 27717-27722 Protein denotes IL-1R
T15820 27666-27671 Protein denotes TRAF6
T15819 27657-27662 Protein denotes IRAK1
T15818 27650-27655 Protein denotes MyD88
T15817 27566-27571 Protein denotes IL-1R
T15816 27464-27469 Protein denotes TIR-8
T15815 27433-27439 Protein denotes SIGIRR
T15814 27388-27431 Protein denotes Single-immunoglobulin IL-1 receptor-related
T15813 27336-27379 Protein denotes Single-immunoglobulin IL-1 receptor-related
T14638 27244-27248 Protein denotes CYLD
T14637 27135-27139 Protein denotes RANK
T14636 27106-27110 Protein denotes CYLD
T14635 26993-26996 Protein denotes p62
T14634 26896-26901 Protein denotes TRAF6
T14633 26862-26866 Protein denotes CYLD
T14632 26824-26838 Protein denotes sequestosome 1
T14631 26805-26808 Protein denotes p62
T14630 26771-26780 Protein denotes ubiquitin
T14629 26757-26762 Protein denotes TRAF6
T14628 26690-26695 Protein denotes RANKL
T14627 26630-26634 Protein denotes CYLD
T14626 26559-26564 Protein denotes RANKL
T14625 26420-26424 Protein denotes CYLD
T14624 26333-26337 Protein denotes RANK
T14623 26290-26294 Protein denotes CYLD
T14622 26143-26147 Protein denotes CYLD
T14621 25985-25988 Protein denotes A20
T14620 25948-25952 Protein denotes CYLD
T14619 25933-25936 Protein denotes A20
T14618 25884-25887 Protein denotes A20
T14617 25843-25847 Protein denotes TAK1
T14616 25834-25838 Protein denotes RIP1
T14615 25827-25832 Protein denotes TRAF7
T14614 25820-25825 Protein denotes TRAF6
T14613 25813-25818 Protein denotes TRAF2
T14612 25807-25811 Protein denotes NEMO
T14611 25674-25678 Protein denotes RANK
T14610 25588-25611 Protein denotes deubiquitinating enzyme
T14609 25578-25582 Protein denotes CYLD
T14608 25385-25389 Protein denotes CYLD
T14607 25279-25283 Protein denotes CYLD
T14606 25262-25277 Protein denotes Cylindromatosis
T14605 25238-25253 Protein denotes Cylindromatosis
T13200 24679-24685 Protein denotes ABIN-1
T13199 24537-24540 Protein denotes A20
T13198 24526-24532 Protein denotes ABIN-3
T13197 24239-24242 Protein denotes A20
T13196 24217-24223 Protein denotes ABIN-1
T13195 24136-24142 Protein denotes ABIN-1
T13194 24076-24079 Protein denotes TNF
T13193 24048-24054 Protein denotes ABIN-1
T13192 23962-23965 Protein denotes TNF
T13191 23915-23921 Protein denotes ABIN-1
T13190 23883-23886 Protein denotes TNF
T13189 23853-23859 Protein denotes ABIN-1
T13188 23848-23851 Protein denotes A20
T13187 23762-23789 Protein denotes truncated and inactive form
T13186 23707-23713 Protein denotes ABIN-3
T13185 23516-23522 Protein denotes ABIN-2
T13184 23495-23501 Protein denotes ABIN-1
T13183 23383-23386 Protein denotes A20
T13182 23308-23314 Protein denotes ABIN-3
T13181 23297-23303 Protein denotes ABIN-1
T13180 23292-23295 Protein denotes A20
T13179 23236-23239 Protein denotes A20
T13178 23080-23083 Protein denotes TNF
T13177 23009-23012 Protein denotes A20
T13176 22959-22965 Protein denotes TNIP-3
T13175 22947-22953 Protein denotes TNIP-2
T13174 22939-22945 Protein denotes TNIP-1
T13173 22917-22923 Protein denotes ABIN-3
T13172 22906-22912 Protein denotes ABIN-2
T13171 22898-22904 Protein denotes ABIN-1
T13170 22866-22869 Protein denotes A20
T10796 22791-22794 Protein denotes A20
T10795 22555-22558 Protein denotes A20
T10794 22507-22510 Protein denotes A20
T10793 22327-22330 Protein denotes A20
T10792 22246-22249 Protein denotes A20
T10791 22208-22216 Protein denotes cytokine
T10790 22176-22179 Protein denotes TNF
T10789 22151-22154 Protein denotes TNF
T10788 22116-22119 Protein denotes A20
T10787 22029-22032 Protein denotes A20
T10786 21982-21985 Protein denotes A20
T10785 21828-21831 Protein denotes A20
T10784 21607-21610 Protein denotes A20
T10783 21461-21464 Protein denotes A20
T10782 21257-21260 Protein denotes A20
T10781 21162-21165 Protein denotes A20
T10780 21013-21016 Protein denotes A20
T10779 21004-21009 Protein denotes IL-1β
T10778 20996-20999 Protein denotes TNF
T10777 20869-20874 Protein denotes IL-1β
T10776 20861-20864 Protein denotes TNF
T10775 20703-20706 Protein denotes A20
T10774 20639-20674 Protein denotes monocyte chemo-attractant protein 1
T10773 20632-20637 Protein denotes RANKL
T10772 20618-20622 Protein denotes IL-6
T10771 20611-20616 Protein denotes IL-1β
T10770 20606-20609 Protein denotes TNF
T10769 20499-20502 Protein denotes A20
T10768 20271-20274 Protein denotes A20
T10767 20168-20171 Protein denotes A20
T10766 20106-20109 Protein denotes A20
T10765 19929-19932 Protein denotes A20
T10764 19798-19801 Protein denotes A20
T10763 19677-19680 Protein denotes A20
T10762 19643-19646 Protein denotes TNF
T10761 19483-19486 Protein denotes A20
T10760 19360-19363 Protein denotes TNF
T10759 19311-19314 Protein denotes A20
T10758 19126-19129 Protein denotes A20
T10757 19062-19065 Protein denotes A20
T10756 18964-18967 Protein denotes A20
T10755 18882-18904 Protein denotes Tax1-binding protein 1
T10754 18838-18877 Protein denotes A20-binding inhibitor of NF-κB (ABIN) 1
T10753 18753-18756 Protein denotes A20
T10752 18691-18694 Protein denotes A20
T10751 18634-18635 Protein denotes 2
T10750 18628-18633 Protein denotes cIAP1
T10749 18618-18623 Protein denotes TRAF2
T10748 18611-18616 Protein denotes TRAF6
T10747 18577-18583 Protein denotes Ubc5hc
T10746 18567-18572 Protein denotes Ubc13
T10745 18404-18409 Protein denotes MALT1
T10744 18394-18399 Protein denotes TRAF6
T10743 18388-18392 Protein denotes RIP2
T10742 18382-18386 Protein denotes RIP1
T10741 18275-18278 Protein denotes A20
T10740 18132-18135 Protein denotes TNF
T10739 18038-18043 Protein denotes NF-κB
T10738 17986-18011 Protein denotes ubiquitin-editing protein
T10737 17972-17979 Protein denotes TNFAIP3
T10736 17953-17956 Protein denotes A20
T10735 17941-17944 Protein denotes A20
T8773 17781-17785 Protein denotes IKK1
T8772 17680-17683 Protein denotes NIK
T8771 17660-17664 Protein denotes IKK1
T8770 17596-17601 Protein denotes STAT1
T8769 17480-17484 Protein denotes IKK1
T8768 17457-17461 Protein denotes IκBα
T8767 17437-17441 Protein denotes IKK2
T8766 17353-17357 Protein denotes IKK1
T8765 17297-17301 Protein denotes IKK1
T8764 17069-17073 Protein denotes IKK1
T8763 16915-16921 Protein denotes TOLLIP
T8762 16903-16909 Protein denotes IRAK-M
T8761 16895-16901 Protein denotes MyD88s
T5900 15890-15894 Protein denotes CD40
T5899 15850-15855 Protein denotes TRAF3
T5898 15803-15808 Protein denotes TRAF2
T5897 15780-15784 Protein denotes IL-6
T5896 15747-15751 Protein denotes CD40
T5895 15725-15730 Protein denotes TRAF6
T5894 15676-15680 Protein denotes CD40
T5893 15499-15504 Protein denotes TRAF3
T5892 15489-15494 Protein denotes TRAF2
T5891 15440-15445 Protein denotes TRAF6
T5890 15429-15434 Protein denotes TRAF5
T5889 15422-15427 Protein denotes TRAF3
T5888 15415-15420 Protein denotes TRAF2
T5887 15408-15413 Protein denotes TRAF1
T5886 15357-15361 Protein denotes RANK
T5885 15348-15352 Protein denotes CD40
T5884 15228-15232 Protein denotes RANK
T5883 15201-15223 Protein denotes lymphotoxin β receptor
T5882 15195-15199 Protein denotes CD40
T5881 13798-13802 Protein denotes IKK1
T5880 13777-13780 Protein denotes NIK
T5879 13725-13728 Protein denotes NIK
T5878 13672-13677 Protein denotes TRAF3
T5877 13634-13635 Protein denotes 2
T5876 13628-13633 Protein denotes cIAP1
T5875 13618-13623 Protein denotes TRAF2
T5874 13540-13545 Protein denotes TRAF3
T5873 13426-13429 Protein denotes NIK
T5872 13395-13396 Protein denotes 2
T5871 13389-13394 Protein denotes cIAP1
T5870 13378-13383 Protein denotes TRAF3
T5869 13371-13376 Protein denotes TRAF2
T5868 13330-13333 Protein denotes NIK
T5867 13185-13188 Protein denotes NIK
T5866 13179-13182 Protein denotes NIK
T5865 13156-13177 Protein denotes NF-κB inducing kinase
T5864 13107-13111 Protein denotes IKK1
T5863 12892-12896 Protein denotes RelB
T5862 12863-12866 Protein denotes p52
T5861 12824-12828 Protein denotes p100
T5860 12790-12794 Protein denotes RANK
T5859 12780-12784 Protein denotes CD40
T5858 12765-12778 Protein denotes BAFF receptor
T5857 12741-12763 Protein denotes lymphotoxin β receptor
T5856 12662-12665 Protein denotes TNF
T5855 12597-12601 Protein denotes TAK1
T5854 12533-12537 Protein denotes RIP1
T5853 12518-12523 Protein denotes TRAF6
T5852 12499-12503 Protein denotes TRIF
T5851 12487-12492 Protein denotes TRAF6
T5850 12427-12432 Protein denotes TRAF6
T5849 12347-12352 Protein denotes MyD88
T5848 12326-12330 Protein denotes TRIF
T5847 12281-12324 Protein denotes TIR domain-containing adaptor-inducing IFNβ
T5846 12270-12275 Protein denotes MyD88
T5845 12220-12268 Protein denotes myeloid differentiation primary response gene 88
T5844 12156-12160 Protein denotes TRAM
T5843 12125-12154 Protein denotes TRIF-related adaptor molecule
T5842 12116-12118 Protein denotes Ma
T5841 12060-12094 Protein denotes Toll/IL-1 receptor adaptor protein
T5840 11994-11998 Protein denotes TLR4
T5839 11906-11910 Protein denotes TAK1
T5838 11680-11683 Protein denotes TNF
T5837 11621-11625 Protein denotes NEMO
T5836 11529-11530 Protein denotes 2
T5835 11524-11528 Protein denotes TAB1
T5834 11515-11519 Protein denotes NEMO
T5833 11467-11471 Protein denotes TAK1
T5832 11405-11409 Protein denotes RIP1
T5831 11308-11312 Protein denotes RIP1
T5830 11282-11283 Protein denotes 2
T5829 11276-11281 Protein denotes cIAP1
T5828 11270-11271 Protein denotes 5
T5827 11264-11269 Protein denotes TRAF2
T5826 11203-11207 Protein denotes RIP1
T5825 11167-11170 Protein denotes TNF
T5824 11146-11151 Protein denotes cIAP2
T5823 11101-11141 Protein denotes cellular inhibitor of apoptosis (cIAP) 1
T5822 11050-11055 Protein denotes TRAF5
T5821 11006-11045 Protein denotes TNF receptor-associated factor (TRAF) 2
T5820 10935-10939 Protein denotes RIP1
T5819 10903-10933 Protein denotes receptor interacting protein 1
T5818 10881-10886 Protein denotes TRADD
T5817 10841-10879 Protein denotes TNF receptor-1-associated death domain
T5816 10795-10798 Protein denotes TNF
T5815 10782-10785 Protein denotes TNF
T5814 8474-8478 Protein denotes IKK1
T5813 8460-8464 Protein denotes NEMO
T5812 8451-8455 Protein denotes IKK2
T5811 8394-8398 Protein denotes IKKγ
T5810 8373-8377 Protein denotes NEMO
T5809 8346-8371 Protein denotes NF-κB essential modulator
T5808 8313-8317 Protein denotes IKKβ
T5807 8304-8308 Protein denotes IKKα
T5806 8284-8288 Protein denotes IKK2
T5805 8275-8279 Protein denotes IKK1
T5804 7830-7835 Protein denotes RANKL
T5803 7808-7811 Protein denotes TNF
T5802 7481-7484 Protein denotes p50
T5801 7473-7476 Protein denotes p52
T5800 7446-7450 Protein denotes p105
T5799 7437-7441 Protein denotes p100
T5798 7374-7379 Protein denotes Bcl-3
T5797 7365-7369 Protein denotes IκBξ
T5796 7326-7332 Protein denotes NF-κB2
T5795 7306-7310 Protein denotes p100
T5794 7297-7303 Protein denotes NF-κB1
T5793 7277-7281 Protein denotes p105
T5792 7271-7275 Protein denotes IκBε
T5791 7265-7269 Protein denotes IκBβ
T5790 7259-7263 Protein denotes IκBα
T2603 6759-6769 Protein denotes tenascin C
T2602 6749-6757 Protein denotes biglycan
T2601 6736-6747 Protein denotes fibronectin
T2600 6565-6569 Protein denotes TLR4
T2599 6341-6367 Protein denotes myeloid-related protein 14
T2598 6311-6336 Protein denotes Myeloid-related protein 8
T2597 6248-6253 Protein denotes HMGB1
T2596 6183-6188 Protein denotes HMGB1
T2595 6138-6143 Protein denotes HMGB1
T2594 6099-6111 Protein denotes TLR4 ligands
T2593 5954-5973 Protein denotes chromatin component
T2592 5927-5932 Protein denotes HMGB1
T2591 5880-5925 Protein denotes High mobility group box chromosomal protein 1
T2590 5011-5033 Protein denotes lymphotoxin β receptor
T2589 4957-4961 Protein denotes BAFF
T2588 4836-4840 Protein denotes BAFF
T2587 4810-4834 Protein denotes B-cell activating factor
T2586 4576-4580 Protein denotes CD40
T2585 4302-4305 Protein denotes CD4
T2584 4235-4240 Protein denotes CD154
T2583 4222-4233 Protein denotes CD40 ligand
T2582 4197-4200 Protein denotes TNF
T2581 3919-3945 Protein denotes TNF receptor family member
T2580 3903-3907 Protein denotes CD40
T2579 3789-3793 Protein denotes RANK
T2578 3693-3697 Protein denotes RANK
T2577 3664-3691 Protein denotes receptor activator of NF-κB
T2576 3450-3453 Protein denotes TNF
T2575 3375-3378 Protein denotes TNF
T2574 3316-3319 Protein denotes TNF
T831 2966-2971 Protein denotes c-REL
T830 2953-2960 Protein denotes TNFAIP3
T829 2946-2951 Protein denotes TRAF1
T828 2940-2944 Protein denotes CD40
T827 2690-2695 Protein denotes RANKL
T826 2654-2688 Protein denotes receptor activator of NF-κB ligand
T825 2035-2038 Protein denotes TNF
T824 1932-1963 Protein denotes inducible nitric oxide synthase
T823 1901-1918 Protein denotes cyclo-oxygenase-2
T822 1895-1899 Protein denotes IL-6
T821 1884-1887 Protein denotes TNF
T820 1758-1763 Protein denotes c-Rel
T819 1752-1756 Protein denotes RelB
T818 1746-1750 Protein denotes RelA
T817 1739-1742 Protein denotes p65
T816 1731-1737 Protein denotes NF-κB1
T815 1723-1727 Protein denotes p105
T814 1715-1721 Protein denotes NF-κB2
T813 1707-1711 Protein denotes p100

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T22376 14102-14107 Protein denotes cIAP1
T22375 14092-14097 Protein denotes TRAF3
T22374 14085-14090 Protein denotes TRAF2
T22373 14028-14031 Protein denotes NIK
T22372 14207-14210 Protein denotes NIK
T22371 14194-14197 Protein denotes NIK
T22370 13982-13985 Protein denotes NIK
T22369 13959-13980 Protein denotes NF-κB inducing kinase
T22368 13889-13893 Protein denotes RANK
T22367 13880-13884 Protein denotes CD40
T22418 14740-14751 Protein_catabolism denotes degradation
T22417 14649-14664 Phosphorylation denotes phosphorylation
T22416 14607-14616 Positive_regulation denotes activates
T22415 14588-14602 Phosphorylation denotes phosphorylates
T22414 14629-14637 Positive_regulation denotes mediates
T22413 14532-14541 Positive_regulation denotes resulting
T22412 14483-14489 Positive_regulation denotes result
T22411 14500-14508 Protein_catabolism denotes degraded
T22410 14545-14554 Positive_regulation denotes increased
T22409 14520-14530 Positive_regulation denotes stabilised
T22408 14432-14450 Binding denotes polyubiquitination
T22407 14253-14262 Binding denotes recruited
T22406 14326-14344 Binding denotes polyubiquitination
T22405 14144-14162 Binding denotes polyubiquitination
T22404 14179-14190 Protein_catabolism denotes degradation
T22403 14117-14128 Positive_regulation denotes facilitates
T22402 13946-13955 Regulation denotes dependent
T22401 13987-13997 Gene_expression denotes expression
T22400 15143-15165 Protein denotes tumour necrosis factor
T22399 15138-15141 Protein denotes TNF
T22398 15071-15098 Protein denotes receptor activator of NF-κB
T22397 15065-15069 Protein denotes RANK
T22396 14846-14851 Protein denotes TRAF1
T22395 14839-14844 Protein denotes TRAF3
T22394 14799-14803 Protein denotes RelB
T22393 14763-14766 Protein denotes p52
T22392 14755-14759 Protein denotes p100
T22391 14644-14648 Protein denotes p100
T22390 14617-14621 Protein denotes IKK1
T22389 14579-14582 Protein denotes NIK
T22388 14555-14558 Protein denotes NIK
T22387 14513-14516 Protein denotes NIK
T22386 14491-14496 Protein denotes TRAF3
T22385 14473-14476 Protein denotes NIK
T22384 14454-14459 Protein denotes TRAF3
T22383 14407-14408 Protein denotes 2
T22382 14401-14406 Protein denotes cIAP1
T22381 14354-14355 Protein denotes 2
T22380 14348-14353 Protein denotes cIAP1
T22379 14286-14291 Protein denotes TRAF2
T22378 14244-14249 Protein denotes TRAF3
T22377 14108-14109 Protein denotes 2
T21070 10010-10017 Binding denotes binding
T21069 9988-9995 Binding denotes compete
T21068 9836-9846 Negative_regulation denotes inhibiting
T21067 9847-9857 Gene_expression denotes expression
T21066 9609-9618 Binding denotes targeting
T21065 9306-9317 Binding denotes heterodimer
T21064 9180-9194 Phosphorylation denotes phosphorylates
T21063 9131-9145 Phosphorylation denotes phosphorylates
T21062 9150-9159 Positive_regulation denotes activates
T21061 8961-8979 Binding denotes polyubiquitination
T21060 9079-9089 Positive_regulation denotes activation
T21059 9063-9074 Binding denotes recruitment
T21058 8599-8609 Binding denotes engagement
T21057 8677-8684 Positive_regulation denotes trigger
T21056 8689-8700 Binding denotes recruitment
T21055 10701-10723 Protein denotes tumour necrosis factor
T21054 10696-10699 Protein denotes TNF
T21053 10558-10600 Protein denotes single-immunoglobulinIL-1 receptor-related
T21052 10550-10556 Protein denotes SIGIRR
T21051 10518-10548 Protein denotes receptor interacting protein 1
T21050 10512-10516 Protein denotes RIP1
T21049 10483-10510 Protein denotes receptor activator of NF-κB
T21048 10477-10481 Protein denotes RANK
T21047 10430-10455 Protein denotes NF-κB essential modulator
T21046 10424-10428 Protein denotes NEMO
T21045 10374-10422 Protein denotes myeloid differentiation primary response gene 88
T21044 10367-10372 Protein denotes MyD88
T21043 10277-10292 Protein denotes cylindromatosis
T21042 10271-10275 Protein denotes CYLD
T21041 10200-10230 Protein denotes A20-binding inhibitor of NF-κB
T21040 10194-10198 Protein denotes ABIN
T21039 10031-10036 Protein denotes TRAF6
T21038 10021-10026 Protein denotes IRAK1
T21037 10001-10005 Protein denotes TLR4
T21036 9953-9959 Protein denotes SIGIRR
T21035 9871-9876 Protein denotes TRAF6
T21034 9861-9866 Protein denotes IRAK1
T21033 9771-9774 Protein denotes p62
T21032 9760-9766 Protein denotes ABIN-1
T21031 9667-9672 Protein denotes TRAF6
T21030 9658-9662 Protein denotes RIP1
T21029 9542-9546 Protein denotes CYLD
T18774 31237-31250 Gene_expression denotes overexpressed
T18773 31067-31076 Gene_expression denotes expressed
T18772 30786-30801 Regulation denotes NF-κB-dependent
T18771 32659-32666 Protein denotes miR-223
T18770 32646-32653 Protein denotes miR-132
T18769 32638-32644 Protein denotes miR-16
T18768 32575-32579 Protein denotes IL-6
T18767 32544-32570 Protein denotes matrix metalloproteinase-1
T18766 32500-32507 Protein denotes miR-203
T18765 32368-32402 Protein denotes monocyte chemoattractant protein 1
T18764 32324-32332 Protein denotes miR-124a
T18763 32152-32159 Protein denotes miR-155
T18762 31754-31761 Protein denotes miR-155
T18761 31680-31683 Protein denotes TNF
T18760 31651-31658 Protein denotes miR-155
T18759 31450-31457 Protein denotes miR-155
T18758 31364-31372 Protein denotes miR-146a
T18757 31263-31268 Protein denotes IL-17
T18756 31254-31257 Protein denotes CD4
T18755 31220-31228 Protein denotes miR-146a
T18754 31055-31062 Protein denotes miR-155
T18753 31015-31019 Protein denotes RIP1
T18752 31006-31010 Protein denotes IKKε
T18751 30931-30938 Protein denotes miR-155
T18750 30894-30902 Protein denotes miR-146a
T18749 30853-30858 Protein denotes TRAF6
T18748 30843-30848 Protein denotes IRAK1
T18747 30771-30779 Protein denotes miR-146a
T18746 30736-30739 Protein denotes TNF
T18745 30729-30734 Protein denotes IL-1β
T18744 30590-30597 Protein denotes miR-155
T18743 30584-30585 Protein denotes b
T18742 30575-30583 Protein denotes miR-146a
T17215 30171-30182 Binding denotes association
T17214 29720-29727 Binding denotes recruit
T17213 29761-29769 Binding denotes interact
T17212 29639-29646 Binding denotes binding
T17211 29336-29345 Negative_regulation denotes deficient
T17210 29128-29137 Negative_regulation denotes deficient
T17209 29038-29047 Positive_regulation denotes inducible
T17208 29059-29073 Gene_expression denotes overexpression
T17207 29015-29025 Gene_expression denotes Expression
T17206 29059-29073 Positive_regulation denotes overexpression
T17205 30190-30195 Protein denotes TRAF1
T17204 30057-30062 Protein denotes TRAF1
T17203 29955-29960 Protein denotes TRAF1
T17202 29728-29731 Protein denotes A20
T17201 29708-29713 Protein denotes TRAF1
T17200 29595-29600 Protein denotes TRAF1
T17199 29528-29533 Protein denotes TRAF1
T17198 29426-29431 Protein denotes TRAF2
T17197 29330-29335 Protein denotes TRAF1
T17196 29299-29303 Protein denotes CD40
T17195 29251-29256 Protein denotes TRAF1
T17194 29122-29127 Protein denotes TRAF1
T17193 29170-29173 Protein denotes TNF
T17192 29092-29095 Protein denotes TNF
T17191 29077-29082 Protein denotes TRAF1
T17190 29051-29054 Protein denotes TNF
T17189 29029-29034 Protein denotes TRAF1
T17188 28862-28867 Protein denotes TRAF1
T17187 28798-28807 Protein denotes ubiquitin
T17186 28688-28693 Protein denotes TRAF1
T17185 28655-28687 Protein denotes TNF receptor-associated factor 1
T16200 28574-28584 Gene_expression denotes expression
T16199 28640-28646 Regulation denotes target
T16198 28391-28401 Gene_expression denotes expression
T16197 28219-28228 Negative_regulation denotes deficient
T16196 28026-28040 Positive_regulation denotes overexpression
T16195 28026-28040 Gene_expression denotes overexpression
T16194 27898-27907 Gene_expression denotes expressed
T16193 27616-27627 Binding denotes interaction
T16192 27553-27562 Negative_regulation denotes inhibitor
T16191 28594-28600 Protein denotes SIGIRR
T16190 28510-28516 Protein denotes SIGIRR
T16189 28405-28411 Protein denotes SIGIRR
T16188 28212-28218 Protein denotes SIGIRR
T16187 28168-28174 Protein denotes SIGIRR
T16186 28019-28025 Protein denotes SIGIRR
T16185 27843-27849 Protein denotes SIGIRR
T16184 27717-27722 Protein denotes IL-1R
T16183 27813-27819 Protein denotes SIGIRR
T16182 27666-27671 Protein denotes TRAF6
T16181 27657-27662 Protein denotes IRAK1
T16180 27650-27655 Protein denotes MyD88
T16179 27566-27571 Protein denotes IL-1R
T16178 27464-27469 Protein denotes TIR-8
T16177 27433-27439 Protein denotes SIGIRR
T16176 27388-27431 Protein denotes Single-immunoglobulin IL-1 receptor-related
T16175 27336-27379 Protein denotes Single-immunoglobulin IL-1 receptor-related
T15301 26964-26974 Gene_expression denotes expressing
T15300 26635-26645 Gene_expression denotes expression
T15299 26781-26788 Binding denotes binding
T15298 26876-26892 Negative_regulation denotes deubiquitination
T15297 26658-26669 Positive_regulation denotes upregulated
T15296 26406-26416 Negative_regulation denotes deficiency
T15295 25997-26006 Gene_expression denotes expressed
T15294 25872-25880 Binding denotes targeted
T15293 27244-27248 Protein denotes CYLD
T15292 27135-27139 Protein denotes RANK
T15291 27106-27110 Protein denotes CYLD
T15290 26993-26996 Protein denotes p62
T15289 26896-26901 Protein denotes TRAF6
T15288 26862-26866 Protein denotes CYLD
T15287 26824-26838 Protein denotes sequestosome 1
T15286 26805-26808 Protein denotes p62
T15285 26771-26780 Protein denotes ubiquitin
T15284 26757-26762 Protein denotes TRAF6
T15283 26690-26695 Protein denotes RANKL
T15282 26630-26634 Protein denotes CYLD
T15281 26559-26564 Protein denotes RANKL
T15280 26420-26424 Protein denotes CYLD
T15279 26333-26337 Protein denotes RANK
T15278 26290-26294 Protein denotes CYLD
T15277 26143-26147 Protein denotes CYLD
T15276 25985-25988 Protein denotes A20
T15275 25948-25952 Protein denotes CYLD
T15274 25933-25936 Protein denotes A20
T15273 25884-25887 Protein denotes A20
T15272 25813-25818 Protein denotes TRAF2
T15271 25807-25811 Protein denotes NEMO
T15270 25674-25678 Protein denotes RANK
T15269 25588-25611 Protein denotes deubiquitinating enzyme
T15268 25578-25582 Protein denotes CYLD
T15267 25843-25847 Protein denotes TAK1
T15266 25834-25838 Protein denotes RIP1
T15265 25827-25832 Protein denotes TRAF7
T15264 25820-25825 Protein denotes TRAF6
T15263 25385-25389 Protein denotes CYLD
T15262 25279-25283 Protein denotes CYLD
T15261 25262-25277 Protein denotes Cylindromatosis
T15260 25238-25253 Protein denotes Cylindromatosis
T13888 24468-24474 Regulation denotes depend
T13887 24482-24492 Gene_expression denotes expression
T13886 24080-24087 Positive_regulation denotes induced
T13885 24126-24132 Transcription denotes levels
T13884 23922-23931 Negative_regulation denotes deficient
T13883 23752-23759 Gene_expression denotes express
T13882 23717-23726 Gene_expression denotes expressed
T13881 23502-23511 Negative_regulation denotes deficient
T13880 23523-23532 Negative_regulation denotes deficient
T13879 23315-23325 Gene_expression denotes expression
T13878 23370-23374 Positive_regulation denotes role
T13877 23229-23235 Binding denotes target
T13876 23013-23024 Binding denotes interacting
T13875 22999-23008 Gene_expression denotes expressed
T13874 22870-22877 Binding denotes binding
T13873 24679-24685 Protein denotes ABIN-1
T13872 24537-24540 Protein denotes A20
T13871 24526-24532 Protein denotes ABIN-3
T13870 24239-24242 Protein denotes A20
T13869 24217-24223 Protein denotes ABIN-1
T13868 24136-24142 Protein denotes ABIN-1
T13867 24076-24079 Protein denotes TNF
T13866 24048-24054 Protein denotes ABIN-1
T13865 23962-23965 Protein denotes TNF
T13864 23915-23921 Protein denotes ABIN-1
T13863 23883-23886 Protein denotes TNF
T13862 23853-23859 Protein denotes ABIN-1
T13861 23848-23851 Protein denotes A20
T13860 23762-23789 Protein denotes truncated and inactive form
T13859 23707-23713 Protein denotes ABIN-3
T13858 23516-23522 Protein denotes ABIN-2
T13857 23495-23501 Protein denotes ABIN-1
T13856 23383-23386 Protein denotes A20
T13855 23308-23314 Protein denotes ABIN-3
T13854 23297-23303 Protein denotes ABIN-1
T13853 23292-23295 Protein denotes A20
T13852 23236-23239 Protein denotes A20
T13851 23080-23083 Protein denotes TNF
T13850 23009-23012 Protein denotes A20
T13849 22959-22965 Protein denotes TNIP-3
T13848 22947-22953 Protein denotes TNIP-2
T13847 22939-22945 Protein denotes TNIP-1
T13846 22917-22923 Protein denotes ABIN-3
T13845 22906-22912 Protein denotes ABIN-2
T13844 22898-22904 Protein denotes ABIN-1
T13843 22866-22869 Protein denotes A20
T12275 22545-22554 Negative_regulation denotes repressed
T12274 22559-22572 Transcription denotes transcription
T12273 22313-22319 Regulation denotes affect
T12272 22155-22162 Positive_regulation denotes induced
T12271 22123-22131 Positive_regulation denotes required
T12270 21972-21981 Regulation denotes influence
T12269 21791-21802 Binding denotes association
T12268 21456-21460 Negative_regulation denotes lack
T12267 21166-21180 Positive_regulation denotes overexpression
T12266 21166-21180 Gene_expression denotes overexpression
T12265 21017-21027 Gene_expression denotes transduced
T12264 20970-20979 Negative_regulation denotes decreased
T12263 20503-20513 Gene_expression denotes expression
T12262 20836-20846 Gene_expression denotes expression
T12261 20553-20563 Negative_regulation denotes inhibition
T12260 20586-20595 Negative_regulation denotes decreased
T12259 20275-20285 Gene_expression denotes expressing
T12258 20131-20140 Regulation denotes regulated
T12257 20110-20120 Gene_expression denotes expression
T12256 19933-19943 Gene_expression denotes expression
T12255 19790-19797 Negative_regulation denotes lacking
T12254 19475-19482 Negative_regulation denotes lacking
T12253 19315-19324 Negative_regulation denotes deficient
T12252 19130-19139 Negative_regulation denotes deficient
T12251 19066-19075 Regulation denotes regulates
T12250 18985-18994 Negative_regulation denotes inhibitor
T12249 18774-18782 Positive_regulation denotes requires
T12248 18766-18773 Regulation denotes targets
T12247 18738-18749 Binding denotes association
T12246 18498-18508 Negative_regulation denotes disruption
T12245 18512-18524 Binding denotes interactions
T12244 18451-18463 Binding denotes interactions
T12243 18028-18037 Regulation denotes regulates
T12242 22791-22794 Protein denotes A20
T12241 22555-22558 Protein denotes A20
T12240 22507-22510 Protein denotes A20
T12239 22327-22330 Protein denotes A20
T12238 22246-22249 Protein denotes A20
T12237 22208-22216 Protein denotes cytokine
T12236 22176-22179 Protein denotes TNF
T12235 22151-22154 Protein denotes TNF
T12234 22116-22119 Protein denotes A20
T12233 22029-22032 Protein denotes A20
T12232 21982-21985 Protein denotes A20
T12231 21828-21831 Protein denotes A20
T12230 21607-21610 Protein denotes A20
T12229 21461-21464 Protein denotes A20
T12228 21257-21260 Protein denotes A20
T12227 21162-21165 Protein denotes A20
T12226 21013-21016 Protein denotes A20
T12225 21004-21009 Protein denotes IL-1β
T12224 20996-20999 Protein denotes TNF
T12223 20869-20874 Protein denotes IL-1β
T12222 20861-20864 Protein denotes TNF
T12221 20703-20706 Protein denotes A20
T12220 20639-20674 Protein denotes monocyte chemo-attractant protein 1
T12219 20632-20637 Protein denotes RANKL
T12218 20618-20622 Protein denotes IL-6
T12217 20611-20616 Protein denotes IL-1β
T12216 20606-20609 Protein denotes TNF
T12215 20499-20502 Protein denotes A20
T12214 20271-20274 Protein denotes A20
T12213 20168-20171 Protein denotes A20
T12212 20106-20109 Protein denotes A20
T12211 19929-19932 Protein denotes A20
T12210 19798-19801 Protein denotes A20
T12209 19677-19680 Protein denotes A20
T12208 19643-19646 Protein denotes TNF
T12207 19483-19486 Protein denotes A20
T12206 19360-19363 Protein denotes TNF
T12205 19311-19314 Protein denotes A20
T12204 19126-19129 Protein denotes A20
T12203 19062-19065 Protein denotes A20
T12202 18964-18967 Protein denotes A20
T12201 18882-18904 Protein denotes Tax1-binding protein 1
T12200 18838-18877 Protein denotes A20-binding inhibitor of NF-κB (ABIN) 1
T12199 18753-18756 Protein denotes A20
T12198 18691-18694 Protein denotes A20
T12197 18634-18635 Protein denotes 2
T12196 18628-18633 Protein denotes cIAP1
T12195 18618-18623 Protein denotes TRAF2
T12194 18611-18616 Protein denotes TRAF6
T12193 18577-18583 Protein denotes Ubc5hc
T12192 18567-18572 Protein denotes Ubc13
T12191 18388-18392 Protein denotes RIP2
T12190 18382-18386 Protein denotes RIP1
T12189 18275-18278 Protein denotes A20
T12188 18404-18409 Protein denotes MALT1
T12187 18394-18399 Protein denotes TRAF6
T12186 18132-18135 Protein denotes TNF
T12185 18038-18043 Protein denotes NF-κB
T12184 17986-18011 Protein denotes ubiquitin-editing protein
T12183 17972-17979 Protein denotes TNFAIP3
T12182 17953-17956 Protein denotes A20
T12181 17941-17944 Protein denotes A20
T9289 17665-17679 Phosphorylation denotes phosphorylates
T9288 17580-17595 Phosphorylation denotes phosphorylating
T9287 17428-17436 Positive_regulation denotes enhanced
T9286 17462-17473 Protein_catabolism denotes degradation
T9285 17418-17424 Positive_regulation denotes result
T9284 17333-17343 Gene_expression denotes expressing
T9283 17442-17452 Positive_regulation denotes activation
T9282 17302-17311 Negative_regulation denotes deficient
T9281 17781-17785 Protein denotes IKK1
T9280 17680-17683 Protein denotes NIK
T9279 17660-17664 Protein denotes IKK1
T9278 17480-17484 Protein denotes IKK1
T9277 17596-17601 Protein denotes STAT1
T9276 17457-17461 Protein denotes IκBα
T9275 17437-17441 Protein denotes IKK2
T9274 17353-17357 Protein denotes IKK1
T9273 17297-17301 Protein denotes IKK1
T9272 17069-17073 Protein denotes IKK1
T9271 16915-16921 Protein denotes TOLLIP
T9270 16903-16909 Protein denotes IRAK-M
T9269 16895-16901 Protein denotes MyD88s
T7967 15785-15795 Gene_expression denotes production
T7966 15734-15742 Positive_regulation denotes required
T7965 15812-15820 Positive_regulation denotes required
T7964 15362-15370 Binding denotes interact
T7963 15469-15480 Protein_catabolism denotes proteolysis
T7962 13803-13818 Phosphorylation denotes phosphorylation
T7961 13715-13724 Localization denotes releasing
T7960 13751-13762 Protein_catabolism denotes degradation
T7959 13764-13773 Positive_regulation denotes resulting
T7958 13781-13793 Positive_regulation denotes accumulation
T7957 13647-13656 Positive_regulation denotes essential
T7956 13533-13539 Negative_regulation denotes remove
T7955 13678-13689 Protein_catabolism denotes degradation
T7954 13610-13617 Binding denotes attract
T7953 13358-13365 Binding denotes complex
T7952 13404-13425 Positive_regulation denotes K48-polyubiquitinates
T7951 13431-13438 Positive_regulation denotes leading
T7950 13457-13468 Protein_catabolism denotes degradation
T7949 13206-13215 Regulation denotes regulated
T7948 13122-13131 Positive_regulation denotes activated
T7947 12911-12920 Regulation denotes regulates
T7946 12588-12596 Positive_regulation denotes activate
T7945 12556-12567 Binding denotes interaction
T7944 12509-12517 Binding denotes recruits
T7943 11999-12010 Positive_regulation denotes stimulation
T7942 12033-12040 Positive_regulation denotes induces
T7941 12045-12056 Binding denotes recruitment
T7940 12212-12219 Binding denotes recruit
T7939 11893-11901 Positive_regulation denotes activate
T7938 11612-11620 Regulation denotes modifies
T7937 11447-11454 Binding denotes recruit
T7936 11313-11327 Binding denotes ubiquitination
T7935 11197-11202 Binding denotes bound
T7934 11219-11227 Regulation denotes modified
T7933 11071-11075 Binding denotes bind
T7932 10799-10810 Negative_regulation denotes stimulation
T7931 10811-10818 Positive_regulation denotes results
T7930 10826-10837 Binding denotes recruitment
T7929 15890-15894 Protein denotes CD40
T7928 15850-15855 Protein denotes TRAF3
T7927 15803-15808 Protein denotes TRAF2
T7926 15780-15784 Protein denotes IL-6
T7925 15747-15751 Protein denotes CD40
T7924 15725-15730 Protein denotes TRAF6
T7923 15676-15680 Protein denotes CD40
T7922 15499-15504 Protein denotes TRAF3
T7921 15489-15494 Protein denotes TRAF2
T7920 15440-15445 Protein denotes TRAF6
T7919 15429-15434 Protein denotes TRAF5
T7918 15422-15427 Protein denotes TRAF3
T7917 15415-15420 Protein denotes TRAF2
T7916 15408-15413 Protein denotes TRAF1
T7915 15357-15361 Protein denotes RANK
T7914 15348-15352 Protein denotes CD40
T7913 15228-15232 Protein denotes RANK
T7912 15201-15223 Protein denotes lymphotoxin β receptor
T7911 15195-15199 Protein denotes CD40
T7910 13798-13802 Protein denotes IKK1
T7909 13777-13780 Protein denotes NIK
T7908 13725-13728 Protein denotes NIK
T7907 13672-13677 Protein denotes TRAF3
T7906 13634-13635 Protein denotes 2
T7905 13628-13633 Protein denotes cIAP1
T7904 13618-13623 Protein denotes TRAF2
T7903 13540-13545 Protein denotes TRAF3
T7902 13395-13396 Protein denotes 2
T7901 13389-13394 Protein denotes cIAP1
T7900 13378-13383 Protein denotes TRAF3
T7899 13371-13376 Protein denotes TRAF2
T7898 13330-13333 Protein denotes NIK
T7897 13426-13429 Protein denotes NIK
T7896 13185-13188 Protein denotes NIK
T7895 13179-13182 Protein denotes NIK
T7894 13156-13177 Protein denotes NF-κB inducing kinase
T7893 13107-13111 Protein denotes IKK1
T7892 12892-12896 Protein denotes RelB
T7891 12863-12866 Protein denotes p52
T7890 12824-12828 Protein denotes p100
T7889 12790-12794 Protein denotes RANK
T7888 12780-12784 Protein denotes CD40
T7887 12765-12778 Protein denotes BAFF receptor
T7886 12741-12763 Protein denotes lymphotoxin β receptor
T7885 12662-12665 Protein denotes TNF
T7884 12597-12601 Protein denotes TAK1
T7883 12533-12537 Protein denotes RIP1
T7882 12518-12523 Protein denotes TRAF6
T7881 12499-12503 Protein denotes TRIF
T7880 12487-12492 Protein denotes TRAF6
T7879 12427-12432 Protein denotes TRAF6
T7878 12347-12352 Protein denotes MyD88
T7877 12326-12330 Protein denotes TRIF
T7876 12281-12324 Protein denotes TIR domain-containing adaptor-inducing IFNβ
T7875 12270-12275 Protein denotes MyD88
T7874 12220-12268 Protein denotes myeloid differentiation primary response gene 88
T7873 12156-12160 Protein denotes TRAM
T7872 12125-12154 Protein denotes TRIF-related adaptor molecule
T7871 12116-12118 Protein denotes Ma
T7870 12060-12094 Protein denotes Toll/IL-1 receptor adaptor protein
T7869 11994-11998 Protein denotes TLR4
T7868 11906-11910 Protein denotes TAK1
T7867 11680-11683 Protein denotes TNF
T7866 11621-11625 Protein denotes NEMO
T7865 11529-11530 Protein denotes 2
T7864 11524-11528 Protein denotes TAB1
T7863 11515-11519 Protein denotes NEMO
T7862 11467-11471 Protein denotes TAK1
T7861 11405-11409 Protein denotes RIP1
T7860 11308-11312 Protein denotes RIP1
T7859 11282-11283 Protein denotes 2
T7858 11276-11281 Protein denotes cIAP1
T7857 11270-11271 Protein denotes 5
T7856 11264-11269 Protein denotes TRAF2
T7855 11203-11207 Protein denotes RIP1
T7854 11167-11170 Protein denotes TNF
T7853 11146-11151 Protein denotes cIAP2
T7852 11101-11141 Protein denotes cellular inhibitor of apoptosis (cIAP) 1
T7851 11050-11055 Protein denotes TRAF5
T7850 11006-11045 Protein denotes TNF receptor-associated factor (TRAF) 2
T7849 10935-10939 Protein denotes RIP1
T7848 10903-10933 Protein denotes receptor interacting protein 1
T7847 10881-10886 Protein denotes TRADD
T7846 10841-10879 Protein denotes TNF receptor-1-associated death domain
T7845 10795-10798 Protein denotes TNF
T7844 10782-10785 Protein denotes TNF
T7843 8474-8478 Protein denotes IKK1
T7842 8460-8464 Protein denotes NEMO
T7841 8451-8455 Protein denotes IKK2
T7840 8394-8398 Protein denotes IKKγ
T7839 8373-8377 Protein denotes NEMO
T7838 8346-8371 Protein denotes NF-κB essential modulator
T7837 8313-8317 Protein denotes IKKβ
T7836 8304-8308 Protein denotes IKKα
T7835 8284-8288 Protein denotes IKK2
T7834 8275-8279 Protein denotes IKK1
T7833 7830-7835 Protein denotes RANKL
T7832 7808-7811 Protein denotes TNF
T7831 7481-7484 Protein denotes p50
T7830 7473-7476 Protein denotes p52
T7829 7446-7450 Protein denotes p105
T7828 7437-7441 Protein denotes p100
T7827 7374-7379 Protein denotes Bcl-3
T7826 7365-7369 Protein denotes IκBξ
T7825 7326-7332 Protein denotes NF-κB2
T7824 7306-7310 Protein denotes p100
T7823 7297-7303 Protein denotes NF-κB1
T7822 7277-7281 Protein denotes p105
T7821 7271-7275 Protein denotes IκBε
T7820 7265-7269 Protein denotes IκBβ
T7819 7259-7263 Protein denotes IκBα
T3583 6570-6577 Positive_regulation denotes induced
T3582 6147-6156 Positive_regulation denotes increased
T3581 6032-6040 Localization denotes released
T3580 5995-6003 Localization denotes secreted
T3579 4765-4775 Gene_expression denotes expression
T3578 4756-4764 Positive_regulation denotes Enhanced
T3577 4207-4214 Binding denotes Binding
T3576 4264-4273 Gene_expression denotes expressed
T3575 3967-3976 Gene_expression denotes expressed
T3574 4146-4157 Positive_regulation denotes upregulated
T3573 6759-6769 Protein denotes tenascin C
T3572 6749-6757 Protein denotes biglycan
T3571 6736-6747 Protein denotes fibronectin
T3570 6565-6569 Protein denotes TLR4
T3569 6341-6367 Protein denotes myeloid-related protein 14
T3568 6311-6336 Protein denotes Myeloid-related protein 8
T3567 6248-6253 Protein denotes HMGB1
T3566 6183-6188 Protein denotes HMGB1
T3565 6138-6143 Protein denotes HMGB1
T3564 6099-6111 Protein denotes TLR4 ligands
T3563 5954-5973 Protein denotes chromatin component
T3562 5927-5932 Protein denotes HMGB1
T3561 5880-5925 Protein denotes High mobility group box chromosomal protein 1
T3560 5011-5033 Protein denotes lymphotoxin β receptor
T3559 4957-4961 Protein denotes BAFF
T3558 4836-4840 Protein denotes BAFF
T3557 4810-4834 Protein denotes B-cell activating factor
T3556 4576-4580 Protein denotes CD40
T3555 4302-4305 Protein denotes CD4
T3554 4235-4240 Protein denotes CD154
T3553 4222-4233 Protein denotes CD40 ligand
T3552 4197-4200 Protein denotes TNF
T3551 3919-3945 Protein denotes TNF receptor family member
T3550 3903-3907 Protein denotes CD40
T3549 3789-3793 Protein denotes RANK
T3548 3693-3697 Protein denotes RANK
T3547 3664-3691 Protein denotes receptor activator of NF-κB
T3546 3450-3453 Protein denotes TNF
T3545 3375-3378 Protein denotes TNF
T3544 3316-3319 Protein denotes TNF
T1527 2869-2880 Binding denotes association
T1526 1836-1846 Gene_expression denotes expression
T1525 1823-1831 Regulation denotes regulate
T1524 2966-2971 Protein denotes c-REL
T1523 2953-2960 Protein denotes TNFAIP3
T1522 2946-2951 Protein denotes TRAF1
T1521 2940-2944 Protein denotes CD40
T1520 2690-2695 Protein denotes RANKL
T1519 2654-2688 Protein denotes receptor activator of NF-κB ligand
T1518 2035-2038 Protein denotes TNF
T1517 1884-1887 Protein denotes TNF
T1516 1758-1763 Protein denotes c-Rel
T1515 1752-1756 Protein denotes RelB
T1514 1746-1750 Protein denotes RelA
T1513 1739-1742 Protein denotes p65
T1512 1731-1737 Protein denotes NF-κB1
T1511 1723-1727 Protein denotes p105
T1510 1715-1721 Protein denotes NF-κB2
T1509 1932-1963 Protein denotes inducible nitric oxide synthase
T1508 1901-1918 Protein denotes cyclo-oxygenase-2
T1507 1895-1899 Protein denotes IL-6
T1506 1707-1711 Protein denotes p100
T21009 8656-8660 Protein denotes CD40
T21008 8926-8931 Protein denotes cIAP2
T21007 8919-8924 Protein denotes cIAP1
T21006 8912-8917 Protein denotes TRAF6
T21005 8905-8910 Protein denotes TRAF2
T21004 8874-8879 Protein denotes IRAK4
T21003 8867-8872 Protein denotes IRAK1
T21002 8861-8865 Protein denotes RIP1
T21001 8844-8848 Protein denotes TRIF
T21000 8649-8654 Protein denotes TNFR1
T21010 8662-8666 Protein denotes RANK
T18785 32702-32712 Gene_expression denotes expression
T18784 32521-32530 Positive_regulation denotes increased
T18783 32531-32540 Localization denotes secretion
T18782 32481-32489 Positive_regulation denotes elevated
T18781 32421-32430 Negative_regulation denotes decreased
T18780 31684-31694 Gene_expression denotes production
T18779 31672-31679 Positive_regulation denotes promote
T18778 31458-31472 Positive_regulation denotes overexpression
T18777 31458-31472 Gene_expression denotes overexpression
T18776 31269-31278 Gene_expression denotes producing
T18775 31237-31250 Positive_regulation denotes overexpressed
T21028 9534-9537 Protein denotes A20
T21027 9400-9405 Protein denotes TRAF1
T21026 9329-9332 Protein denotes p50
T21025 9321-9324 Protein denotes p65
T21024 9195-9199 Protein denotes IκBα
T21023 9160-9164 Protein denotes IKK2
T21022 9121-9125 Protein denotes TAK1
T21021 9115-9119 Protein denotes TAK1
T21020 9106-9110 Protein denotes IKK2
T21019 9023-9027 Protein denotes NEMO
T21018 8999-9004 Protein denotes IRAK1
T21017 8990-8994 Protein denotes RIP1
T21016 8799-8842 Protein denotes TIR domain-containing adaptor-inducing IFNβ
T21015 8794-8797 Protein denotes MAL
T21014 8787-8792 Protein denotes MyD88
T21013 8779-8784 Protein denotes TRADD
T21012 8731-8777 Protein denotes TNF receptor 1-associated death domain protein
T21011 8672-8676 Protein denotes TLR4
R1206 T1507 T1526 themeOf IL-6,expression
R1254 T1508 T1526 themeOf cyclo-oxygenase-2,expression
R1255 T1509 T1526 themeOf inducible nitric oxide synthase,expression
R1256 T1517 T1526 themeOf TNF,expression
R1257 T1523 T1527 themeOf TNFAIP3,association
R1259 T1526 T1525 themeOf expression,regulate
R1260 T1526 T1525 themeOf expression,regulate
R1261 T1526 T1525 themeOf expression,regulate
R1262 T1526 T1525 themeOf expression,regulate
R2748 T3550 T3574 themeOf CD40,upregulated
R2749 T3550 T3575 themeOf CD40,expressed
R2751 T3551 T3574 themeOf TNF receptor family member,upregulated
R2752 T3551 T3575 themeOf TNF receptor family member,expressed
R2753 T3552 T3574 causeOf TNF,upregulated
R2754 T3552 T3574 causeOf TNF,upregulated
R2755 T3553 T3576 themeOf CD40 ligand,expressed
R2756 T3553 T3577 themeOf CD40 ligand,Binding
R2757 T3554 T3576 themeOf CD154,expressed
R2758 T3554 T3577 themeOf CD154,Binding
R2759 T3557 T3579 themeOf B-cell activating factor,expression
R2760 T3558 T3579 themeOf BAFF,expression
R2761 T3561 T3580 themeOf High mobility group box chromosomal protein 1,secreted
R2762 T3561 T3581 themeOf High mobility group box chromosomal protein 1,released
R2763 T3562 T3581 themeOf HMGB1,released
R2764 T3563 T3580 themeOf chromatin component,secreted
R2765 T3563 T3581 themeOf chromatin component,released
R2766 T3564 T3581 themeOf TLR4 ligands,released
R2767 T3565 T3582 themeOf HMGB1,increased
R2769 T3570 T3583 themeOf TLR4,induced
R2770 T3579 T3578 themeOf expression,Enhanced
R2771 T3579 T3578 themeOf expression,Enhanced
R5432 T7855 T7935 themeOf RIP1,bound
R5433 T7855 T7934 themeOf RIP1,modified
R5435 T7845 T7932 themeOf TNF,stimulation
R5437 T7846 T7930 themeOf TNF receptor-1-associated death domain,recruitment
R5438 T7847 T7930 themeOf TRADD,recruitment
R5439 T7848 T7930 themeOf receptor interacting protein 1,recruitment
R5441 T7849 T7930 themeOf RIP1,recruitment
R5443 T7851 T7933 themeOf TRAF5,bind
R5444 T7851 T7933 themeOf TRAF5,bind
R5446 T7852 T7933 themeOf cellular inhibitor of apoptosis (cIAP) 1,bind
R5447 T7853 T7933 themeOf cIAP2,bind
R5492 T7906 T7954 themeOf 2,attract
R5494 T7907 T7955 themeOf TRAF3,degradation
R5496 T7908 T7960 themeOf NIK,degradation
R5535 T7924 T7966 causeOf TRAF6,required
R5536 T7926 T7967 themeOf IL-6,production
R5537 T7927 T7965 themeOf TRAF2,required
R5538 T7930 T7931 themeOf recruitment,results
R5540 T7930 T7931 themeOf recruitment,results
R5541 T7930 T7931 themeOf recruitment,results
R5542 T7930 T7931 themeOf recruitment,results
R5543 T7941 T7942 themeOf recruitment,induces
R5546 T7941 T7942 themeOf recruitment,induces
R5547 T7941 T7942 themeOf recruitment,induces
R5548 T7950 T7951 themeOf degradation,leading
R6305 T9273 T9282 themeOf IKK1,deficient
R6306 T9274 T9284 themeOf IKK1,expressing
R6307 T9275 T9283 themeOf IKK2,activation
R6308 T9276 T9286 themeOf IκBα,degradation
R6309 T9277 T9288 themeOf STAT1,phosphorylating
R6310 T9280 T9289 themeOf NIK,phosphorylates
R6311 T9283 T9287 themeOf activation,enhanced
R6312 T9284 T9282 themeOf expressing,deficient
R6313 T9286 T9285 themeOf degradation,result
R8223 T12182 T12243 themeOf A20,regulates
R8225 T12257 T12258 themeOf expression,regulated
R8226 T12191 T12244 themeOf RIP2,interactions
R8227 T12192 T12246 themeOf Ubc13,disruption
R8228 T12192 T12245 themeOf Ubc13,interactions
R8229 T12193 T12245 themeOf Ubc5hc,interactions
R8230 T12194 T12245 themeOf TRAF6,interactions
R8231 T12195 T12245 themeOf TRAF2,interactions
R8232 T12196 T12245 themeOf cIAP1,interactions
R8233 T12197 T12245 themeOf 2,interactions
R8234 T12266 T12267 themeOf overexpression,overexpression
R8235 T12199 T12247 themeOf A20,association
R8236 T12200 T12249 themeOf A20-binding inhibitor of NF-κB (ABIN) 1,requires
R8237 T12202 T12250 themeOf A20,inhibitor
R8238 T12203 T12251 themeOf A20,regulates
R8239 T12204 T12252 themeOf A20,deficient
R8240 T12205 T12253 themeOf A20,deficient
R8241 T12207 T12254 themeOf A20,lacking
R8242 T12210 T12255 themeOf A20,lacking
R8243 T12274 T12275 themeOf transcription,repressed
R8244 T12211 T12256 themeOf A20,expression
R8245 T12212 T12257 themeOf A20,expression
R8246 T12214 T12259 themeOf A20,expressing
R8247 T12215 T12263 themeOf A20,expression
R8248 T12216 T12261 themeOf TNF,inhibition
R8249 T12216 T12260 themeOf TNF,decreased
R8250 T12217 T12261 themeOf IL-1β,inhibition
R8251 T12217 T12260 themeOf IL-1β,decreased
R8252 T12218 T12261 themeOf IL-6,inhibition
R8253 T12218 T12260 themeOf IL-6,decreased
R8254 T12219 T12260 themeOf RANKL,decreased
R8255 T12220 T12261 themeOf monocyte chemo-attractant protein 1,inhibition
R8256 T12220 T12260 themeOf monocyte chemo-attractant protein 1,decreased
R8257 T12221 T12262 themeOf A20,expression
R8258 T12224 T12264 themeOf TNF,decreased
R8259 T12225 T12264 themeOf IL-1β,decreased
R8260 T12226 T12265 themeOf A20,transduced
R8262 T12227 T12266 themeOf A20,overexpression
R8263 T12229 T12268 themeOf A20,lack
R8264 T12231 T12269 themeOf A20,association
R8265 T12232 T12270 themeOf A20,influence
R8266 T12234 T12271 themeOf A20,required
R8267 T12235 T12272 themeOf TNF,induced
R8268 T12239 T12273 themeOf A20,affect
R8269 T12241 T12274 themeOf A20,transcription
R8272 T12247 T12248 themeOf association,targets
R9260 T13843 T13874 themeOf A20,binding
R9261 T13845 T13875 themeOf ABIN-2,expressed
R9262 T13846 T13875 themeOf ABIN-3,expressed
R9263 T13847 T13875 themeOf TNIP-1,expressed
R9264 T13848 T13875 themeOf TNIP-2,expressed
R9265 T13850 T13875 themeOf A20,expressed
R9266 T13850 T13876 themeOf A20,interacting
R9267 T13852 T13877 themeOf A20,target
R9268 T13854 T13879 themeOf ABIN-1,expression
R9269 T13855 T13879 themeOf ABIN-3,expression
R9270 T13856 T13878 themeOf A20,role
R9271 T13857 T13881 themeOf ABIN-1,deficient
R9272 T13857 T13880 themeOf ABIN-1,deficient
R9273 T13858 T13880 themeOf ABIN-2,deficient
R9274 T13859 T13882 themeOf ABIN-3,expressed
R9275 T13860 T13883 themeOf truncated and inactive form,express
R9276 T13864 T13884 themeOf ABIN-1,deficient
R9277 T13867 T13886 themeOf TNF,induced
R9278 T13868 T13885 themeOf ABIN-1,levels
R9280 T13872 T13887 themeOf A20,expression
R9281 T13887 T13888 themeOf expression,depend
R9282 T13887 T13888 themeOf expression,depend
R10719 T16176 T16192 themeOf Single-immunoglobulin IL-1 receptor-related,inhibitor
R10720 T16176 T16193 themeOf Single-immunoglobulin IL-1 receptor-related,interaction
R10721 T16177 T16192 themeOf SIGIRR,inhibitor
R10722 T16177 T16193 themeOf SIGIRR,interaction
R10723 T16178 T16192 themeOf TIR-8,inhibitor
R10724 T16178 T16193 themeOf TIR-8,interaction
R10725 T16179 T16192 themeOf IL-1R,inhibitor
R10726 T16181 T16192 themeOf IRAK1,inhibitor
R10727 T16181 T16193 themeOf IRAK1,interaction
R10728 T16185 T16194 themeOf SIGIRR,expressed
R10729 T16186 T16195 themeOf SIGIRR,overexpression
R10730 T16188 T16197 themeOf SIGIRR,deficient
R10731 T16189 T16198 themeOf SIGIRR,expression
R10732 T16191 T16199 themeOf SIGIRR,target
R10733 T16191 T16200 themeOf SIGIRR,expression
R10734 T16195 T16196 themeOf overexpression,overexpression
R11350 T17189 T17207 themeOf TRAF1,Expression
R11351 T17190 T17209 causeOf TNF,inducible
R11352 T17191 T17208 themeOf TRAF1,overexpression
R11353 T17194 T17210 themeOf TRAF1,deficient
R11354 T17197 T17211 themeOf TRAF1,deficient
R11355 T17200 T17212 themeOf TRAF1,binding
R11356 T17201 T17214 themeOf TRAF1,recruit
R11357 T17202 T17213 themeOf A20,interact
R11358 T17202 T17214 themeOf A20,recruit
R11359 T17205 T17215 themeOf TRAF1,association
R11360 T17207 T17209 themeOf Expression,inducible
R11361 T17208 T17206 themeOf overexpression,overexpression
R12435 T18747 T18772 themeOf miR-146a,NF-κB-dependent
R12436 T18754 T18773 themeOf miR-155,expressed
R12437 T18755 T18774 themeOf miR-146a,overexpressed
R12438 T18757 T18776 themeOf IL-17,producing
R12439 T18759 T18777 themeOf miR-155,overexpression
R12440 T18761 T18780 themeOf TNF,production
R12441 T18764 T18781 themeOf miR-124a,decreased
R12442 T18766 T18782 themeOf miR-203,elevated
R12443 T18767 T18783 themeOf matrix metalloproteinase-1,secretion
R12444 T18768 T18783 themeOf IL-6,secretion
R12445 T18770 T18785 themeOf miR-132,expression
R12446 T18774 T18775 themeOf overexpressed,overexpressed
R12447 T18777 T18778 themeOf overexpression,overexpression
R12448 T18780 T18779 themeOf production,promote
R12449 T18783 T18784 themeOf secretion,increased
R12450 T18783 T18784 themeOf secretion,increased
R13828 T21000 T21058 themeOf TNFR1,engagement
R13829 T21001 T21056 themeOf TRIF,recruitment
R13830 T21002 T21056 themeOf RIP1,recruitment
R13831 T21003 T21056 themeOf IRAK1,recruitment
R13832 T21004 T21056 themeOf IRAK4,recruitment
R13833 T21005 T21056 themeOf TRAF2,recruitment
R13834 T21006 T21056 themeOf TRAF6,recruitment
R13835 T21007 T21056 themeOf cIAP1,recruitment
R13836 T21008 T21056 themeOf cIAP2,recruitment
R13837 T21009 T21058 themeOf CD40,engagement
R13838 T21010 T21058 themeOf RANK,engagement
R13839 T21011 T21058 themeOf TLR4,engagement
R13840 T21012 T21056 themeOf TNF receptor 1-associated death domain protein,recruitment
R13841 T21013 T21056 themeOf TRADD,recruitment
R13842 T21014 T21056 themeOf MyD88,recruitment
R13843 T21015 T21056 themeOf MAL,recruitment
R13844 T21016 T21056 themeOf TIR domain-containing adaptor-inducing IFNβ,recruitment
R13845 T21017 T21061 themeOf RIP1,polyubiquitination
R13846 T21018 T21061 themeOf IRAK1,polyubiquitination
R13847 T21020 T21059 themeOf IKK2,recruitment
R13848 T21021 T21059 themeOf TAK1,recruitment
R13849 T21021 T21060 themeOf TAK1,activation
R13850 T21022 T21063 themeOf TAK1,phosphorylates
R13851 T21022 T21062 causeOf TAK1,activates
R13852 T21023 T21063 themeOf IKK2,phosphorylates
R13853 T21023 T21062 themeOf IKK2,activates
R13854 T21024 T21064 themeOf IκBα,phosphorylates
R13855 T21025 T21065 themeOf p65,heterodimer
R13856 T21026 T21065 themeOf p50,heterodimer
R13857 T21028 T21066 themeOf A20,targeting
R13858 T21028 T21066 themeOf A20,targeting
R13859 T21030 T21066 themeOf RIP1,targeting
R13860 T21031 T21066 themeOf TRAF6,targeting
R13861 T21034 T21067 themeOf IRAK1,expression
R13862 T21035 T21067 themeOf TRAF6,expression
R13863 T21037 T21069 themeOf TLR4,compete
R13864 T21037 T21070 themeOf TLR4,binding
R13865 T21037 T21070 themeOf TLR4,binding
R13866 T21038 T21070 themeOf IRAK1,binding
R13867 T21039 T21070 themeOf TRAF6,binding
R13868 T21056 T21057 themeOf recruitment,trigger
R13869 T21056 T21057 themeOf recruitment,trigger
R13870 T21056 T21057 themeOf recruitment,trigger
R13871 T21056 T21057 themeOf recruitment,trigger
R13872 T21056 T21057 themeOf recruitment,trigger
R13873 T21056 T21057 themeOf recruitment,trigger
R13874 T21056 T21057 themeOf recruitment,trigger
R13875 T21056 T21057 themeOf recruitment,trigger
R13876 T21056 T21057 themeOf recruitment,trigger
R13880 T21056 T21057 themeOf recruitment,trigger
R13881 T21067 T21068 themeOf expression,inhibiting
R13882 T21067 T21068 themeOf expression,inhibiting
R14569 T22369 T22402 themeOf NF-κB inducing kinase,dependent
R14570 T22369 T22401 themeOf NF-κB inducing kinase,expression
R14571 T22370 T22401 themeOf NIK,expression
R14572 T22371 T22405 themeOf NIK,polyubiquitination
R14573 T22371 T22404 themeOf NIK,degradation
R14575 T22380 T22406 themeOf cIAP1,polyubiquitination
R14591 T22404 T22403 themeOf degradation,facilitates
R14592 T22405 T22403 themeOf polyubiquitination,facilitates
R5434 T7860 T7936 themeOf RIP1,ubiquitination
R5436 T7862 T7937 themeOf TAK1,recruit
R5440 T7862 T7937 themeOf TAK1,recruit
R5442 T7862 T7937 themeOf TAK1,recruit
R5445 T7863 T7937 themeOf NEMO,recruit
R5448 T7864 T7937 themeOf TAB1,recruit
R5449 T7865 T7937 themeOf 2,recruit
R5450 T7955 T7957 themeOf degradation,essential
R5451 T7866 T7938 themeOf NEMO,modifies
R5452 T7958 T7959 themeOf accumulation,resulting
R5453 T7868 T7939 themeOf TAK1,activate
R5454 T7962 T7959 themeOf phosphorylation,resulting
R5455 T7869 T7943 themeOf TLR4,stimulation
R5456 T7870 T7941 themeOf Toll/IL-1 receptor adaptor protein,recruitment
R5457 T7872 T7941 themeOf TRIF-related adaptor molecule,recruitment
R5459 T7873 T7941 themeOf TRAM,recruitment
R5460 T7874 T7940 themeOf myeloid differentiation primary response gene 88,recruit
R5461 T7875 T7940 themeOf MyD88,recruit
R5462 T7876 T7940 themeOf TIR domain-containing adaptor-inducing IFNβ,recruit
R5463 T7877 T7940 themeOf TRIF,recruit
R5464 T7881 T7945 themeOf TRIF,interaction
R5465 T7882 T7944 themeOf TRAF6,recruits
R5466 T7883 T7944 themeOf RIP1,recruits
R5469 T7884 T7946 themeOf TAK1,activate
R5470 T7892 T7947 themeOf RelB,regulates
R5476 T7893 T7948 themeOf IKK1,activated
R5477 T7893 T7948 themeOf IKK1,activated
R5478 T7894 T7948 causeOf NF-κB inducing kinase,activated
R5480 T7895 T7948 causeOf NIK,activated
R5481 T7896 T7949 themeOf NIK,regulated
R5482 T7897 T7952 themeOf NIK,K48-polyubiquitinates
R5483 T7897 T7950 themeOf NIK,degradation
R5484 T7901 T7953 themeOf cIAP1,complex
R5485 T7903 T7956 themeOf TRAF3,remove
R5486 T7904 T7954 themeOf TRAF2,attract
R5488 T7905 T7954 themeOf cIAP1,attract
R5490 T7905 T7957 themeOf cIAP1,essential
R5458 T7967 T7966 themeOf production,required
R5498 T7908 T7961 themeOf NIK,releasing
R5499 T7909 T7958 themeOf NIK,accumulation
R5503 T7910 T7962 themeOf IKK1,phosphorylation
R5504 T7914 T7964 themeOf CD40,interact
R5507 T7914 T7964 themeOf CD40,interact
R5509 T7914 T7964 themeOf CD40,interact
R5510 T7914 T7964 themeOf CD40,interact
R5512 T7914 T7964 themeOf CD40,interact
R5513 T7915 T7964 themeOf RANK,interact
R5515 T7915 T7964 themeOf RANK,interact
R5516 T7915 T7964 themeOf RANK,interact
R5517 T7915 T7964 themeOf RANK,interact
R5518 T7915 T7964 themeOf RANK,interact
R5519 T7916 T7964 themeOf TRAF1,interact
R5520 T7916 T7964 themeOf TRAF1,interact
R5521 T7917 T7964 themeOf TRAF2,interact
R5523 T7917 T7964 themeOf TRAF2,interact
R5524 T7918 T7964 themeOf TRAF3,interact
R5525 T7918 T7964 themeOf TRAF3,interact
R5526 T7919 T7964 themeOf TRAF5,interact
R5528 T7919 T7964 themeOf TRAF5,interact
R5529 T7920 T7964 themeOf TRAF6,interact
R5531 T7920 T7964 themeOf TRAF6,interact
R5533 T7921 T7963 themeOf TRAF2,proteolysis
R5534 T7922 T7963 themeOf TRAF3,proteolysis
R9279 T13871 T13887 themeOf ABIN-3,expression
R10133 T15273 T15294 themeOf A20,targeted
R10134 T15276 T15295 themeOf A20,expressed
R10135 T15280 T15296 themeOf CYLD,deficiency
R10136 T15282 T15300 themeOf CYLD,expression
R10137 T15285 T15299 themeOf ubiquitin,binding
R10138 T15286 T15299 themeOf p62,binding
R10139 T15286 T15300 themeOf p62,expression
R10140 T15289 T15298 themeOf TRAF6,deubiquitination
R10141 T15290 T15301 themeOf p62,expressing
R10142 T15300 T15297 themeOf expression,upregulated
R10143 T15300 T15297 themeOf expression,upregulated
R13877 T21056 T21057 themeOf recruitment,trigger
R13878 T21056 T21057 themeOf recruitment,trigger
R13879 T21056 T21057 themeOf recruitment,trigger
R14574 T22378 T22407 themeOf TRAF3,recruited
R14576 T22381 T22406 themeOf 2,polyubiquitination
R14577 T22382 T22408 themeOf cIAP1,polyubiquitination
R14578 T22384 T22408 themeOf TRAF3,polyubiquitination
R14579 T22385 T22408 themeOf NIK,polyubiquitination
R14580 T22386 T22411 themeOf TRAF3,degraded
R14581 T22387 T22409 themeOf NIK,stabilised
R14582 T22388 T22413 themeOf NIK,resulting
R14583 T22388 T22410 themeOf NIK,increased
R14584 T22389 T22415 themeOf NIK,phosphorylates
R14585 T22389 T22416 causeOf NIK,activates
R14586 T22390 T22415 themeOf IKK1,phosphorylates
R14587 T22390 T22416 themeOf IKK1,activates
R14588 T22391 T22417 themeOf p100,phosphorylation
R14589 T22392 T22418 themeOf p100,degradation
R14590 T22393 T22418 themeOf p52,degradation
R14593 T22411 T22412 themeOf degraded,result
R14594 T22417 T22414 themeOf phosphorylation,mediates

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T22109 13959-13980 Protein denotes NF-κB inducing kinase
T22108 13889-13893 Protein denotes RANK
T22107 13880-13884 Protein denotes CD40
T22155 14740-14751 Protein_catabolism denotes degradation
T22154 14607-14616 Positive_regulation denotes activates
T22153 14588-14602 Phosphorylation denotes phosphorylates
T22152 14649-14664 Phosphorylation denotes phosphorylation
T22151 14629-14637 Positive_regulation denotes mediates
T22150 14545-14554 Positive_regulation denotes increased
T22149 14500-14508 Protein_catabolism denotes degraded
T22147 14326-14344 Binding denotes polyubiquitination
T22146 14376-14386 Positive_regulation denotes activation
T22145 14253-14262 Binding denotes recruited
T22144 14179-14190 Protein_catabolism denotes degradation
T22143 14144-14162 Binding denotes polyubiquitination
T22142 13987-13997 Gene_expression denotes expression
T22141 13946-13955 Regulation denotes dependent
T22140 15143-15165 Protein denotes tumour necrosis factor
T22139 15138-15141 Protein denotes TNF
T22138 15071-15098 Protein denotes receptor activator of NF-κB
T22137 15065-15069 Protein denotes RANK
T22136 14846-14851 Protein denotes TRAF1
T22135 14839-14844 Protein denotes TRAF3
T22134 14799-14803 Protein denotes RelB
T22133 14763-14766 Protein denotes p52
T22132 14755-14759 Protein denotes p100
T22131 14644-14648 Protein denotes p100
T22130 14617-14621 Protein denotes IKK1
T22129 14579-14582 Protein denotes NIK
T22128 14555-14558 Protein denotes NIK
T22127 14513-14516 Protein denotes NIK
T22126 14491-14496 Protein denotes TRAF3
T22125 14473-14476 Protein denotes NIK
T22124 14454-14459 Protein denotes TRAF3
T22123 14407-14408 Protein denotes 2
T22122 14401-14406 Protein denotes cIAP1
T22121 14354-14355 Protein denotes 2
T22120 14348-14353 Protein denotes cIAP1
T22119 14286-14291 Protein denotes TRAF2
T22118 14244-14249 Protein denotes TRAF3
T22117 14108-14109 Protein denotes 2
T22116 14102-14107 Protein denotes cIAP1
T22115 14092-14097 Protein denotes TRAF3
T22114 14085-14090 Protein denotes TRAF2
T22113 14028-14031 Protein denotes NIK
T22112 14207-14210 Protein denotes NIK
T22111 14194-14197 Protein denotes NIK
T22110 13982-13985 Protein denotes NIK
T20659 9914-9923 Negative_regulation denotes inhibited
T20658 10010-10017 Binding denotes binding
T20649 8961-8979 Positive_regulation denotes polyubiquitination
T20648 9046-9055 Positive_regulation denotes resulting
T20647 8599-8609 Binding denotes engagement
T20646 8689-8700 Binding denotes recruitment
T20645 10701-10723 Protein denotes tumour necrosis factor
T20644 10696-10699 Protein denotes TNF
T20643 10558-10600 Protein denotes single-immunoglobulinIL-1 receptor-related
T20642 10550-10556 Protein denotes SIGIRR
T20641 10518-10548 Protein denotes receptor interacting protein 1
T20640 10512-10516 Protein denotes RIP1
T20639 10483-10510 Protein denotes receptor activator of NF-κB
T20638 10477-10481 Protein denotes RANK
T20637 10430-10455 Protein denotes NF-κB essential modulator
T20636 10424-10428 Protein denotes NEMO
T20635 10374-10422 Protein denotes myeloid differentiation primary response gene 88
T20634 10367-10372 Protein denotes MyD88
T20633 10277-10292 Protein denotes cylindromatosis
T20632 10271-10275 Protein denotes CYLD
T20631 10200-10230 Protein denotes A20-binding inhibitor of NF-κB
T20630 10194-10198 Protein denotes ABIN
T20629 10031-10036 Protein denotes TRAF6
T20628 10021-10026 Protein denotes IRAK1
T20627 10001-10005 Protein denotes TLR4
T20626 9953-9959 Protein denotes SIGIRR
T20625 9871-9876 Protein denotes TRAF6
T20624 9861-9866 Protein denotes IRAK1
T20623 9771-9774 Protein denotes p62
T20622 9760-9766 Protein denotes ABIN-1
T20621 9667-9672 Protein denotes TRAF6
T20620 9658-9662 Protein denotes RIP1
T20619 9542-9546 Protein denotes CYLD
T20618 9534-9537 Protein denotes A20
T20617 9400-9405 Protein denotes TRAF1
T20616 9329-9332 Protein denotes p50
T20615 9321-9324 Protein denotes p65
T20614 9195-9199 Protein denotes IκBα
T20613 9160-9164 Protein denotes IKK2
T20612 9121-9125 Protein denotes TAK1
T20611 9115-9119 Protein denotes TAK1
T20610 9106-9110 Protein denotes IKK2
T20609 9023-9027 Protein denotes NEMO
T20608 8999-9004 Protein denotes IRAK1
T20607 8990-8994 Protein denotes RIP1
T20606 8799-8842 Protein denotes TIR domain-containing adaptor-inducing IFNβ
T20605 8794-8797 Protein denotes MAL
T20604 8787-8792 Protein denotes MyD88
T20603 8779-8784 Protein denotes TRADD
T20602 8731-8777 Protein denotes TNF receptor 1-associated death domain protein
T20601 8672-8676 Protein denotes TLR4
T20600 8662-8666 Protein denotes RANK
T20599 8656-8660 Protein denotes CD40
T20598 8926-8931 Protein denotes cIAP2
T20597 8919-8924 Protein denotes cIAP1
T20596 8912-8917 Protein denotes TRAF6
T20595 8905-8910 Protein denotes TRAF2
T20594 8874-8879 Protein denotes IRAK4
T20593 8867-8872 Protein denotes IRAK1
T20592 8861-8865 Protein denotes RIP1
T20591 8844-8848 Protein denotes TRIF
T20590 8649-8654 Protein denotes TNFR1
T18550 32531-32540 Localization denotes secretion
T18549 32481-32489 Positive_regulation denotes elevated
T18548 32521-32530 Positive_regulation denotes increased
T18547 32421-32430 Negative_regulation denotes decreased
T18546 31672-31679 Positive_regulation denotes promote
T18545 31684-31694 Gene_expression denotes production
T18544 31458-31472 Positive_regulation denotes overexpression
T18543 31373-31379 Binding denotes target
T18542 31269-31278 Gene_expression denotes producing
T18541 31237-31250 Gene_expression denotes overexpressed
T18540 31067-31076 Gene_expression denotes expressed
T18539 30689-30696 Positive_regulation denotes induced
T18538 32659-32666 Protein denotes miR-223
T18537 32646-32653 Protein denotes miR-132
T18536 32638-32644 Protein denotes miR-16
T18535 32575-32579 Protein denotes IL-6
T18534 32544-32570 Protein denotes matrix metalloproteinase-1
T18533 32500-32507 Protein denotes miR-203
T18532 32368-32402 Protein denotes monocyte chemoattractant protein 1
T18531 32324-32332 Protein denotes miR-124a
T18530 32152-32159 Protein denotes miR-155
T18529 31754-31761 Protein denotes miR-155
T18528 31680-31683 Protein denotes TNF
T18527 31651-31658 Protein denotes miR-155
T18526 31450-31457 Protein denotes miR-155
T18525 31364-31372 Protein denotes miR-146a
T18524 31263-31268 Protein denotes IL-17
T18523 31254-31257 Protein denotes CD4
T18522 31220-31228 Protein denotes miR-146a
T18521 31055-31062 Protein denotes miR-155
T18520 31015-31019 Protein denotes RIP1
T18519 31006-31010 Protein denotes IKKε
T18518 30931-30938 Protein denotes miR-155
T18517 30894-30902 Protein denotes miR-146a
T18516 30853-30858 Protein denotes TRAF6
T18515 30843-30848 Protein denotes IRAK1
T18514 30771-30779 Protein denotes miR-146a
T18513 30736-30739 Protein denotes TNF
T18512 30729-30734 Protein denotes IL-1β
T18511 30590-30597 Protein denotes miR-155
T18510 30584-30585 Protein denotes b
T18509 30575-30583 Protein denotes miR-146a
T17040 30171-30182 Binding denotes association
T17039 29720-29727 Binding denotes recruit
T17038 29761-29769 Binding denotes interact
T17037 29639-29646 Binding denotes binding
T17036 29336-29345 Negative_regulation denotes deficient
T17035 29128-29137 Negative_regulation denotes deficient
T17034 29015-29025 Gene_expression denotes Expression
T17033 29059-29073 Positive_regulation denotes overexpression
T17032 29038-29047 Positive_regulation denotes inducible
T17031 30190-30195 Protein denotes TRAF1
T17030 30057-30062 Protein denotes TRAF1
T17029 29955-29960 Protein denotes TRAF1
T17028 29728-29731 Protein denotes A20
T17027 29708-29713 Protein denotes TRAF1
T17026 29595-29600 Protein denotes TRAF1
T17025 29528-29533 Protein denotes TRAF1
T17024 29426-29431 Protein denotes TRAF2
T17023 29330-29335 Protein denotes TRAF1
T17022 29299-29303 Protein denotes CD40
T17021 29251-29256 Protein denotes TRAF1
T17020 29122-29127 Protein denotes TRAF1
T17019 29170-29173 Protein denotes TNF
T17018 29092-29095 Protein denotes TNF
T17017 29077-29082 Protein denotes TRAF1
T17016 29051-29054 Protein denotes TNF
T17015 29029-29034 Protein denotes TRAF1
T17014 28862-28867 Protein denotes TRAF1
T17013 28798-28807 Protein denotes ubiquitin
T17012 28688-28693 Protein denotes TRAF1
T17011 28655-28687 Protein denotes TNF receptor-associated factor 1
T16083 28574-28584 Gene_expression denotes expression
T16082 28640-28646 Regulation denotes target
T16081 28391-28401 Gene_expression denotes expression
T16080 28219-28228 Negative_regulation denotes deficient
T16079 28026-28040 Positive_regulation denotes overexpression
T16078 27898-27907 Gene_expression denotes expressed
T16077 27553-27562 Negative_regulation denotes inhibitor
T16076 27616-27627 Binding denotes interaction
T16075 28594-28600 Protein denotes SIGIRR
T16074 28510-28516 Protein denotes SIGIRR
T16073 28405-28411 Protein denotes SIGIRR
T16072 28212-28218 Protein denotes SIGIRR
T16064 27650-27655 Protein denotes MyD88
T16063 27566-27571 Protein denotes IL-1R
T16062 27464-27469 Protein denotes TIR-8
T16061 27433-27439 Protein denotes SIGIRR
T16060 27388-27431 Protein denotes Single-immunoglobulin IL-1 receptor-related
T16059 27336-27379 Protein denotes Single-immunoglobulin IL-1 receptor-related
T15071 26964-26974 Gene_expression denotes expressing
T15069 26658-26669 Positive_regulation denotes upregulated
T15068 26730-26739 Binding denotes recruited
T15067 26876-26892 Negative_regulation denotes deubiquitination
T15066 26635-26645 Gene_expression denotes expression
T15065 26565-26572 Positive_regulation denotes induced
T15064 26406-26416 Negative_regulation denotes deficiency
T15063 25997-26006 Gene_expression denotes expressed
T15062 27244-27248 Protein denotes CYLD
T15061 27135-27139 Protein denotes RANK
T15060 27106-27110 Protein denotes CYLD
T15059 26993-26996 Protein denotes p62
T15058 26896-26901 Protein denotes TRAF6
T15057 26862-26866 Protein denotes CYLD
T15056 26824-26838 Protein denotes sequestosome 1
T15055 26805-26808 Protein denotes p62
T15054 26771-26780 Protein denotes ubiquitin
T15053 26757-26762 Protein denotes TRAF6
T15052 26690-26695 Protein denotes RANKL
T15051 26630-26634 Protein denotes CYLD
T15050 26559-26564 Protein denotes RANKL
T15049 26420-26424 Protein denotes CYLD
T15048 26333-26337 Protein denotes RANK
T15047 26290-26294 Protein denotes CYLD
T15046 26143-26147 Protein denotes CYLD
T15045 25985-25988 Protein denotes A20
T15044 25948-25952 Protein denotes CYLD
T15043 25933-25936 Protein denotes A20
T15042 25884-25887 Protein denotes A20
T15041 25813-25818 Protein denotes TRAF2
T15040 25807-25811 Protein denotes NEMO
T15039 25674-25678 Protein denotes RANK
T15038 25588-25611 Protein denotes deubiquitinating enzyme
T15037 25578-25582 Protein denotes CYLD
T15036 25843-25847 Protein denotes TAK1
T15035 25834-25838 Protein denotes RIP1
T15034 25827-25832 Protein denotes TRAF7
T15033 25820-25825 Protein denotes TRAF6
T15032 25385-25389 Protein denotes CYLD
T15031 25279-25283 Protein denotes CYLD
T15030 25262-25277 Protein denotes Cylindromatosis
T15029 25238-25253 Protein denotes Cylindromatosis
T13674 24468-24474 Regulation denotes depend
T13673 24482-24492 Gene_expression denotes expression
T13672 24080-24087 Positive_regulation denotes induced
T13671 23887-23894 Positive_regulation denotes induced
T13670 23874-23882 Negative_regulation denotes inhibits
T13669 23922-23931 Negative_regulation denotes deficient
T13668 23752-23759 Gene_expression denotes express
T13667 23717-23726 Gene_expression denotes expressed
T13666 23790-23797 Negative_regulation denotes lacking
T13665 23523-23532 Negative_regulation denotes deficient
T13664 23502-23511 Negative_regulation denotes deficient
T13663 23315-23325 Gene_expression denotes expression
T13662 23229-23235 Binding denotes target
T13661 23013-23024 Binding denotes interacting
T13660 22999-23008 Gene_expression denotes expressed
T13659 22870-22877 Binding denotes binding
T13658 24679-24685 Protein denotes ABIN-1
T13657 24537-24540 Protein denotes A20
T13656 24526-24532 Protein denotes ABIN-3
T13655 24239-24242 Protein denotes A20
T13654 24217-24223 Protein denotes ABIN-1
T13653 24136-24142 Protein denotes ABIN-1
T13652 24076-24079 Protein denotes TNF
T13651 24048-24054 Protein denotes ABIN-1
T13650 23962-23965 Protein denotes TNF
T13649 23915-23921 Protein denotes ABIN-1
T13648 23883-23886 Protein denotes TNF
T13647 23853-23859 Protein denotes ABIN-1
T13646 23848-23851 Protein denotes A20
T13645 23762-23789 Protein denotes truncated and inactive form
T13644 23707-23713 Protein denotes ABIN-3
T13643 23516-23522 Protein denotes ABIN-2
T13642 23495-23501 Protein denotes ABIN-1
T13641 23383-23386 Protein denotes A20
T13640 23308-23314 Protein denotes ABIN-3
T13639 23297-23303 Protein denotes ABIN-1
T13638 23292-23295 Protein denotes A20
T13637 23236-23239 Protein denotes A20
T13636 23080-23083 Protein denotes TNF
T13635 23009-23012 Protein denotes A20
T13634 22959-22965 Protein denotes TNIP-3
T13633 22947-22953 Protein denotes TNIP-2
T13632 22939-22945 Protein denotes TNIP-1
T13631 22917-22923 Protein denotes ABIN-3
T13630 22906-22912 Protein denotes ABIN-2
T13629 22898-22904 Protein denotes ABIN-1
T11762 18753-18756 Protein denotes A20
T11761 18691-18694 Protein denotes A20
T11760 18634-18635 Protein denotes 2
T11759 18628-18633 Protein denotes cIAP1
T11758 18618-18623 Protein denotes TRAF2
T11757 18611-18616 Protein denotes TRAF6
T11756 18577-18583 Protein denotes Ubc5hc
T11755 18567-18572 Protein denotes Ubc13
T11754 18388-18392 Protein denotes RIP2
T11753 18382-18386 Protein denotes RIP1
T11752 18275-18278 Protein denotes A20
T11751 18404-18409 Protein denotes MALT1
T11750 18394-18399 Protein denotes TRAF6
T11749 18132-18135 Protein denotes TNF
T11748 18038-18043 Protein denotes NF-κB
T11747 17986-18011 Protein denotes ubiquitin-editing protein
T11746 17972-17979 Protein denotes TNFAIP3
T11745 17953-17956 Protein denotes A20
T11744 17941-17944 Protein denotes A20
T11833 22545-22554 Negative_regulation denotes repressed
T11826 21166-21180 Positive_regulation denotes overexpression
T11810 18985-18994 Negative_regulation denotes inhibitor
T11809 18766-18773 Regulation denotes targets
T11808 18774-18782 Positive_regulation denotes requires
T11807 18738-18749 Binding denotes association
T11806 18498-18508 Negative_regulation denotes disruption
T11805 22791-22794 Protein denotes A20
T11804 22555-22558 Protein denotes A20
T11803 22507-22510 Protein denotes A20
T11802 22327-22330 Protein denotes A20
T11801 22246-22249 Protein denotes A20
T11800 22208-22216 Protein denotes cytokine
T11799 22176-22179 Protein denotes TNF
T11798 22151-22154 Protein denotes TNF
T11797 22116-22119 Protein denotes A20
T11796 22029-22032 Protein denotes A20
T11795 21982-21985 Protein denotes A20
T11794 21828-21831 Protein denotes A20
T11793 21607-21610 Protein denotes A20
T11792 21461-21464 Protein denotes A20
T11791 21257-21260 Protein denotes A20
T11790 21162-21165 Protein denotes A20
T11789 21013-21016 Protein denotes A20
T11788 21004-21009 Protein denotes IL-1β
T9148 17665-17679 Phosphorylation denotes phosphorylates
T9147 17580-17595 Phosphorylation denotes phosphorylating
T9146 17428-17436 Positive_regulation denotes enhanced
T9145 17302-17311 Negative_regulation denotes deficient
T9144 17418-17424 Positive_regulation denotes result
T9143 17462-17473 Protein_catabolism denotes degradation
T9142 17442-17452 Positive_regulation denotes activation
T9141 17333-17343 Gene_expression denotes expressing
T9140 17781-17785 Protein denotes IKK1
T9139 17680-17683 Protein denotes NIK
T9138 17660-17664 Protein denotes IKK1
T9137 17480-17484 Protein denotes IKK1
T9136 17596-17601 Protein denotes STAT1
T9135 17457-17461 Protein denotes IκBα
T9134 17437-17441 Protein denotes IKK2
T9133 17353-17357 Protein denotes IKK1
T9132 17297-17301 Protein denotes IKK1
T9131 17069-17073 Protein denotes IKK1
T9130 16915-16921 Protein denotes TOLLIP
T9129 16903-16909 Protein denotes IRAK-M
T9128 16895-16901 Protein denotes MyD88s
T7083 15812-15820 Positive_regulation denotes required
T7082 15785-15795 Gene_expression denotes production
T7081 15734-15742 Positive_regulation denotes required
T7080 15362-15370 Binding denotes interact
T7079 13803-13818 Phosphorylation denotes phosphorylation
T7078 13781-13793 Positive_regulation denotes accumulation
T7077 13751-13762 Protein_catabolism denotes degradation
T7076 13764-13773 Positive_regulation denotes resulting
T7075 13715-13724 Negative_regulation denotes releasing
T7074 13533-13539 Negative_regulation denotes remove
T7073 13567-13577 Binding denotes recruiting
T7072 13610-13617 Binding denotes attract
T7071 13647-13656 Positive_regulation denotes essential
T7070 13678-13689 Protein_catabolism denotes degradation
T7069 13457-13468 Protein_catabolism denotes degradation
T7068 13206-13215 Regulation denotes regulated
T7067 13122-13131 Positive_regulation denotes activated
T7066 12588-12596 Positive_regulation denotes activate
T7065 12509-12517 Binding denotes recruits
T7064 12556-12567 Binding denotes interaction
T7063 11999-12010 Positive_regulation denotes stimulation
T7062 12212-12219 Binding denotes recruit
T7061 12033-12040 Positive_regulation denotes induces
T7060 12045-12056 Binding denotes recruitment
T7059 11612-11620 Regulation denotes modifies
T7058 11447-11454 Binding denotes recruit
T7057 11313-11327 Binding denotes ubiquitination
T7056 11197-11202 Binding denotes bound
T7055 11071-11075 Binding denotes bind
T7054 10826-10837 Binding denotes recruitment
T7053 8484-8492 Positive_regulation denotes required
T7052 15890-15894 Protein denotes CD40
T7051 15850-15855 Protein denotes TRAF3
T7050 15803-15808 Protein denotes TRAF2
T7049 15780-15784 Protein denotes IL-6
T7048 15747-15751 Protein denotes CD40
T7047 15725-15730 Protein denotes TRAF6
T7046 15676-15680 Protein denotes CD40
T7045 15499-15504 Protein denotes TRAF3
T7044 15489-15494 Protein denotes TRAF2
T7043 15440-15445 Protein denotes TRAF6
T7042 15429-15434 Protein denotes TRAF5
T7041 15422-15427 Protein denotes TRAF3
T7040 15415-15420 Protein denotes TRAF2
T7011 12780-12784 Protein denotes CD40
T7010 12765-12778 Protein denotes BAFF receptor
T7009 12741-12763 Protein denotes lymphotoxin β receptor
T7008 12662-12665 Protein denotes TNF
T7007 12597-12601 Protein denotes TAK1
T7006 12533-12537 Protein denotes RIP1
T7005 12518-12523 Protein denotes TRAF6
T7004 12499-12503 Protein denotes TRIF
T7003 12487-12492 Protein denotes TRAF6
T7002 12427-12432 Protein denotes TRAF6
T7001 12347-12352 Protein denotes MyD88
T7000 12326-12330 Protein denotes TRIF
T6999 12281-12324 Protein denotes TIR domain-containing adaptor-inducing IFNβ
T6998 12270-12275 Protein denotes MyD88
T6997 12220-12268 Protein denotes myeloid differentiation primary response gene 88
T6996 12156-12160 Protein denotes TRAM
T6995 12125-12154 Protein denotes TRIF-related adaptor molecule
T6994 12116-12118 Protein denotes Ma
T6993 12060-12094 Protein denotes Toll/IL-1 receptor adaptor protein
T6992 11994-11998 Protein denotes TLR4
T6991 11906-11910 Protein denotes TAK1
T6990 11680-11683 Protein denotes TNF
T6989 11621-11625 Protein denotes NEMO
T6988 11529-11530 Protein denotes 2
T6987 11524-11528 Protein denotes TAB1
T6986 11515-11519 Protein denotes NEMO
T6985 11467-11471 Protein denotes TAK1
T6984 11405-11409 Protein denotes RIP1
T6983 11308-11312 Protein denotes RIP1
T6982 11282-11283 Protein denotes 2
T6981 11276-11281 Protein denotes cIAP1
T6980 11270-11271 Protein denotes 5
T6979 11264-11269 Protein denotes TRAF2
T6978 11203-11207 Protein denotes RIP1
T6977 11167-11170 Protein denotes TNF
T6976 11146-11151 Protein denotes cIAP2
T6975 11101-11141 Protein denotes cellular inhibitor of apoptosis (cIAP) 1
T6974 11050-11055 Protein denotes TRAF5
T6973 11006-11045 Protein denotes TNF receptor-associated factor (TRAF) 2
T6972 10935-10939 Protein denotes RIP1
T6971 10903-10933 Protein denotes receptor interacting protein 1
T6970 10881-10886 Protein denotes TRADD
T6969 10841-10879 Protein denotes TNF receptor-1-associated death domain
T6968 10795-10798 Protein denotes TNF
T6967 10782-10785 Protein denotes TNF
T6966 8474-8478 Protein denotes IKK1
T6965 8460-8464 Protein denotes NEMO
T6964 8451-8455 Protein denotes IKK2
T6963 8394-8398 Protein denotes IKKγ
T6962 8373-8377 Protein denotes NEMO
T6961 8346-8371 Protein denotes NF-κB essential modulator
T6960 8313-8317 Protein denotes IKKβ
T6959 8304-8308 Protein denotes IKKα
T6958 8284-8288 Protein denotes IKK2
T6957 8275-8279 Protein denotes IKK1
T6956 7830-7835 Protein denotes RANKL
T6955 7808-7811 Protein denotes TNF
T6954 7481-7484 Protein denotes p50
T6953 7473-7476 Protein denotes p52
T6952 7446-7450 Protein denotes p105
T6951 7437-7441 Protein denotes p100
T6950 7374-7379 Protein denotes Bcl-3
T6949 7365-7369 Protein denotes IκBξ
T6948 7326-7332 Protein denotes NF-κB2
T6947 7306-7310 Protein denotes p100
T6946 7297-7303 Protein denotes NF-κB1
T6945 7277-7281 Protein denotes p105
T6944 7271-7275 Protein denotes IκBε
T6943 7265-7269 Protein denotes IκBβ
T6942 7259-7263 Protein denotes IκBα
T3327 6570-6577 Positive_regulation denotes induced
T3326 6147-6156 Positive_regulation denotes increased
T3325 6032-6040 Localization denotes released
T3324 5995-6003 Localization denotes secreted
T3323 4756-4764 Positive_regulation denotes Enhanced
T3322 4765-4775 Gene_expression denotes expression
T3321 4264-4273 Gene_expression denotes expressed
T3320 4207-4214 Binding denotes Binding
T3319 3967-3976 Gene_expression denotes expressed
T3318 4146-4157 Positive_regulation denotes upregulated
T3317 6759-6769 Protein denotes tenascin C
T3316 6749-6757 Protein denotes biglycan
T3304 5011-5033 Protein denotes lymphotoxin β receptor
T3303 4957-4961 Protein denotes BAFF
T3302 4836-4840 Protein denotes BAFF
T3301 4810-4834 Protein denotes B-cell activating factor
T3300 4576-4580 Protein denotes CD40
T3299 4302-4305 Protein denotes CD4
T3298 4235-4240 Protein denotes CD154
T3297 4222-4233 Protein denotes CD40 ligand
T3296 4197-4200 Protein denotes TNF
T3295 3919-3945 Protein denotes TNF receptor family member
T3294 3903-3907 Protein denotes CD40
T3293 3789-3793 Protein denotes RANK
T3292 3693-3697 Protein denotes RANK
T3291 3664-3691 Protein denotes receptor activator of NF-κB
T3290 3450-3453 Protein denotes TNF
T3289 3375-3378 Protein denotes TNF
T3288 3316-3319 Protein denotes TNF
T1299 1823-1831 Regulation denotes regulate
T1298 1836-1846 Gene_expression denotes expression
T1297 2966-2971 Protein denotes c-REL
T1296 2953-2960 Protein denotes TNFAIP3
T1295 2946-2951 Protein denotes TRAF1
T1294 2940-2944 Protein denotes CD40
T1293 2690-2695 Protein denotes RANKL
T1292 2654-2688 Protein denotes receptor activator of NF-κB ligand
T1291 2035-2038 Protein denotes TNF
T1290 1884-1887 Protein denotes TNF
T1289 1758-1763 Protein denotes c-Rel
T1288 1752-1756 Protein denotes RelB
T1287 1746-1750 Protein denotes RelA
T1286 1739-1742 Protein denotes p65
T1285 1731-1737 Protein denotes NF-κB1
T1284 1723-1727 Protein denotes p105
T1283 1715-1721 Protein denotes NF-κB2
T1282 1932-1963 Protein denotes inducible nitric oxide synthase
T1281 1901-1918 Protein denotes cyclo-oxygenase-2
T1280 1895-1899 Protein denotes IL-6
T1279 1707-1711 Protein denotes p100
T3315 6736-6747 Protein denotes fibronectin
T3314 6565-6569 Protein denotes TLR4
T3313 6341-6367 Protein denotes myeloid-related protein 14
T3312 6311-6336 Protein denotes Myeloid-related protein 8
T3311 6248-6253 Protein denotes HMGB1
T3310 6183-6188 Protein denotes HMGB1
T3309 6138-6143 Protein denotes HMGB1
T3308 6099-6111 Protein denotes TLR4 ligands
T3307 5954-5973 Protein denotes chromatin component
T3306 5927-5932 Protein denotes HMGB1
T3305 5880-5925 Protein denotes High mobility group box chromosomal protein 1
T7024 13389-13394 Protein denotes cIAP1
T7023 13378-13383 Protein denotes TRAF3
T7022 13371-13376 Protein denotes TRAF2
T7021 13330-13333 Protein denotes NIK
T7020 13426-13429 Protein denotes NIK
T7019 13185-13188 Protein denotes NIK
T7018 13179-13182 Protein denotes NIK
T7017 13156-13177 Protein denotes NF-κB inducing kinase
T7016 13107-13111 Protein denotes IKK1
T7015 12892-12896 Protein denotes RelB
T7014 12863-12866 Protein denotes p52
T7013 12824-12828 Protein denotes p100
T7012 12790-12794 Protein denotes RANK
T7039 15408-15413 Protein denotes TRAF1
T7038 15357-15361 Protein denotes RANK
T7037 15348-15352 Protein denotes CD40
T7036 15228-15232 Protein denotes RANK
T7035 15201-15223 Protein denotes lymphotoxin β receptor
T7034 15195-15199 Protein denotes CD40
T7033 13798-13802 Protein denotes IKK1
T7032 13777-13780 Protein denotes NIK
T7031 13725-13728 Protein denotes NIK
T7030 13672-13677 Protein denotes TRAF3
T7029 13634-13635 Protein denotes 2
T7028 13628-13633 Protein denotes cIAP1
T7027 13618-13623 Protein denotes TRAF2
T7026 13540-13545 Protein denotes TRAF3
T7025 13395-13396 Protein denotes 2
T11769 19360-19363 Protein denotes TNF
T11768 19311-19314 Protein denotes A20
T11767 19126-19129 Protein denotes A20
T11766 19062-19065 Protein denotes A20
T11765 18964-18967 Protein denotes A20
T11764 18882-18904 Protein denotes Tax1-binding protein 1
T11763 18838-18877 Protein denotes A20-binding inhibitor of NF-κB (ABIN) 1
T11787 20996-20999 Protein denotes TNF
T11786 20869-20874 Protein denotes IL-1β
T11785 20861-20864 Protein denotes TNF
T11784 20703-20706 Protein denotes A20
T11783 20639-20674 Protein denotes monocyte chemo-attractant protein 1
T11782 20632-20637 Protein denotes RANKL
T11781 20618-20622 Protein denotes IL-6
T11780 20611-20616 Protein denotes IL-1β
T11779 20606-20609 Protein denotes TNF
T11778 20499-20502 Protein denotes A20
T11777 20271-20274 Protein denotes A20
T11776 20168-20171 Protein denotes A20
T11775 20106-20109 Protein denotes A20
T11774 19929-19932 Protein denotes A20
T11773 19798-19801 Protein denotes A20
T11772 19677-19680 Protein denotes A20
T11771 19643-19646 Protein denotes TNF
T11770 19483-19486 Protein denotes A20
T11816 19933-19943 Gene_expression denotes expression
T11815 19790-19797 Negative_regulation denotes lacking
T11814 19475-19482 Negative_regulation denotes lacking
T11813 19647-19654 Positive_regulation denotes induced
T11812 19315-19324 Negative_regulation denotes deficient
T11811 19130-19139 Negative_regulation denotes deficient
T11825 20970-20979 Negative_regulation denotes decreased
T11824 20707-20714 Positive_regulation denotes induces
T11823 20586-20595 Negative_regulation denotes decreased
T11822 20553-20563 Negative_regulation denotes inhibition
T11821 20503-20513 Gene_expression denotes expression
T11820 20836-20846 Gene_expression denotes expression
T11819 20275-20285 Gene_expression denotes expressing
T11818 20131-20140 Regulation denotes regulated
T11817 20110-20120 Gene_expression denotes expression
T13628 22866-22869 Protein denotes A20
T11832 22559-22572 Transcription denotes transcription
T11831 22123-22131 Positive_regulation denotes required
T11830 22155-22162 Positive_regulation denotes induced
T11829 21972-21981 Regulation denotes influence
T11828 21791-21802 Binding denotes association
T11827 21456-21460 Negative_regulation denotes lack
T15070 26781-26788 Binding denotes binding
T16071 28168-28174 Protein denotes SIGIRR
T16070 28019-28025 Protein denotes SIGIRR
T16069 27843-27849 Protein denotes SIGIRR
T16068 27717-27722 Protein denotes IL-1R
T16067 27813-27819 Protein denotes SIGIRR
T16066 27666-27671 Protein denotes TRAF6
T16065 27657-27662 Protein denotes IRAK1
T22148 14432-14450 Binding denotes polyubiquitination
T20657 9988-9995 Negative_regulation denotes compete
T20656 9847-9857 Gene_expression denotes expression
T20655 9836-9846 Negative_regulation denotes inhibiting
T20654 9609-9618 Binding denotes targeting
T20653 9180-9194 Phosphorylation denotes phosphorylates
T20652 9150-9159 Positive_regulation denotes activates
T20651 9131-9145 Phosphorylation denotes phosphorylates
T20650 9063-9074 Binding denotes recruitment
R1058 T1281 T1298 themeOf cyclo-oxygenase-2,expression
R1059 T1283 T1299 causeOf NF-κB2,regulate
R1064 T1298 T1299 themeOf expression,regulate
R2612 T3294 T3319 themeOf CD40,expressed
R2613 T3295 T3318 themeOf TNF receptor family member,upregulated
R2614 T3295 T3319 themeOf TNF receptor family member,expressed
R2616 T3297 T3321 themeOf CD40 ligand,expressed
R2617 T3297 T3320 themeOf CD40 ligand,Binding
R2618 T3298 T3321 themeOf CD154,expressed
R2619 T3298 T3320 themeOf CD154,Binding
R2621 T3301 T3322 themeOf B-cell activating factor,expression
R2623 T3302 T3322 themeOf BAFF,expression
R2627 T3305 T3325 themeOf High mobility group box chromosomal protein 1,released
R2628 T3307 T3324 themeOf chromatin component,secreted
R2629 T3307 T3325 themeOf chromatin component,released
R2630 T3309 T3326 themeOf HMGB1,increased
R2633 T3314 T3327 themeOf TLR4,induced
R2637 T3322 T3323 themeOf expression,Enhanced
R2638 T3322 T3323 themeOf expression,Enhanced
R4903 T6964 T7053 causeOf IKK2,required
R4905 T6965 T7053 themeOf NEMO,required
R4906 T6965 T7053 themeOf NEMO,required
R4907 T6966 T7053 causeOf IKK1,required
R4909 T6969 T7054 themeOf TNF receptor-1-associated death domain,recruitment
R4910 T6970 T7054 themeOf TRADD,recruitment
R4911 T6971 T7054 themeOf receptor interacting protein 1,recruitment
R4913 T6972 T7054 themeOf RIP1,recruitment
R4915 T6975 T7055 themeOf cellular inhibitor of apoptosis (cIAP) 1,bind
R4916 T6976 T7055 themeOf cIAP2,bind
R4919 T6978 T7056 themeOf RIP1,bound
R4922 T6983 T7057 themeOf RIP1,ubiquitination
R4924 T6986 T7058 themeOf NEMO,recruit
R4925 T6987 T7058 themeOf TAB1,recruit
R4927 T6988 T7058 themeOf 2,recruit
R4928 T6989 T7059 themeOf NEMO,modifies
R4930 T6992 T7063 themeOf TLR4,stimulation
R4932 T6993 T7060 themeOf Toll/IL-1 receptor adaptor protein,recruitment
R4933 T6995 T7060 themeOf TRIF-related adaptor molecule,recruitment
R4935 T6996 T7060 themeOf TRAM,recruitment
R4936 T6997 T7062 themeOf myeloid differentiation primary response gene 88,recruit
R4937 T6998 T7062 themeOf MyD88,recruit
R4939 T6999 T7062 themeOf TIR domain-containing adaptor-inducing IFNβ,recruit
R4940 T7000 T7062 themeOf TRIF,recruit
R4942 T7004 T7064 themeOf TRIF,interaction
R4944 T7005 T7064 themeOf TRAF6,interaction
R4945 T7005 T7065 themeOf TRAF6,recruits
R4946 T7006 T7065 themeOf RIP1,recruits
R4947 T7007 T7066 themeOf TAK1,activate
R4952 T7016 T7067 causeOf IKK1,activated
R4954 T7017 T7067 themeOf NF-κB inducing kinase,activated
R4956 T7019 T7068 themeOf NIK,regulated
R4959 T7025 T7069 themeOf 2,degradation
R4960 T7026 T7074 themeOf TRAF3,remove
R4961 T7026 T7073 themeOf TRAF3,recruiting
R4962 T7027 T7072 themeOf TRAF2,attract
R4963 T7028 T7072 themeOf cIAP1,attract
R4964 T7029 T7072 themeOf 2,attract
R4965 T7030 T7070 themeOf TRAF3,degradation
R4966 T7031 T7077 themeOf NIK,degradation
R4967 T7031 T7075 themeOf NIK,releasing
R4968 T7032 T7078 themeOf NIK,accumulation
R4969 T7033 T7079 themeOf IKK1,phosphorylation
R4970 T7037 T7080 themeOf CD40,interact
R4971 T7038 T7080 themeOf RANK,interact
R4972 T7047 T7081 causeOf TRAF6,required
R4977 T7049 T7082 themeOf IL-6,production
R4986 T7050 T7083 themeOf TRAF2,required
R5008 T7060 T7061 themeOf recruitment,induces
R5031 T7060 T7061 themeOf recruitment,induces
R5038 T7060 T7061 themeOf recruitment,induces
R5039 T7063 T7061 causeOf stimulation,induces
R5050 T7063 T7061 causeOf stimulation,induces
R5051 T7063 T7061 causeOf stimulation,induces
R5052 T7070 T7071 themeOf degradation,essential
R5067 T7077 T7075 themeOf degradation,releasing
R5072 T7078 T7076 themeOf accumulation,resulting
R5075 T7079 T7076 themeOf phosphorylation,resulting
R5076 T7082 T7081 themeOf production,required
R6247 T9132 T9145 themeOf IKK1,deficient
R6248 T9133 T9141 themeOf IKK1,expressing
R6249 T9134 T9142 themeOf IKK2,activation
R6250 T9135 T9143 themeOf IκBα,degradation
R6251 T9136 T9147 themeOf STAT1,phosphorylating
R6252 T9139 T9148 themeOf NIK,phosphorylates
R6253 T9142 T9146 themeOf activation,enhanced
R6254 T9143 T9144 themeOf degradation,result
R8025 T11755 T11806 themeOf Ubc13,disruption
R8028 T11756 T11806 themeOf Ubc5hc,disruption
R8030 T11759 T11806 themeOf cIAP1,disruption
R8032 T11762 T11807 themeOf A20,association
R8036 T11763 T11808 themeOf A20-binding inhibitor of NF-κB (ABIN) 1,requires
R8038 T11765 T11810 themeOf A20,inhibitor
R8040 T11767 T11811 themeOf A20,deficient
R8042 T11768 T11812 themeOf A20,deficient
R8045 T11770 T11814 themeOf A20,lacking
R8047 T11771 T11813 themeOf TNF,induced
R8049 T11773 T11815 themeOf A20,lacking
R8050 T11774 T11816 themeOf A20,expression
R8051 T11775 T11817 themeOf A20,expression
R8053 T11777 T11819 themeOf A20,expressing
R8054 T11778 T11821 themeOf A20,expression
R8056 T11779 T11822 themeOf TNF,inhibition
R8057 T11779 T11823 themeOf TNF,decreased
R8058 T11780 T11822 themeOf IL-1β,inhibition
R8059 T11780 T11823 themeOf IL-1β,decreased
R8060 T11781 T11822 themeOf IL-6,inhibition
R8061 T11781 T11823 themeOf IL-6,decreased
R8062 T11782 T11823 themeOf RANKL,decreased
R8064 T11783 T11823 themeOf monocyte chemo-attractant protein 1,decreased
R8065 T11784 T11824 themeOf A20,induces
R8066 T11784 T11820 themeOf A20,expression
R8068 T11787 T11825 themeOf TNF,decreased
R8069 T11788 T11825 themeOf IL-1β,decreased
R8071 T11790 T11826 themeOf A20,overexpression
R8073 T11792 T11827 themeOf A20,lack
R8074 T11794 T11828 themeOf A20,association
R8076 T11795 T11829 themeOf A20,influence
R8078 T11797 T11831 themeOf A20,required
R8079 T11798 T11830 themeOf TNF,induced
R8082 T11804 T11832 themeOf A20,transcription
R8084 T11807 T11809 themeOf association,targets
R8085 T11807 T11808 causeOf association,requires
R8093 T11817 T11818 themeOf expression,regulated
R8095 T11822 T11823 themeOf inhibition,decreased
R8096 T11822 T11823 themeOf inhibition,decreased
R8097 T11822 T11823 themeOf inhibition,decreased
R8101 T11832 T11833 themeOf transcription,repressed
R9156 T13628 T13659 themeOf A20,binding
R9157 T13630 T13660 themeOf ABIN-2,expressed
R9158 T13635 T13661 themeOf A20,interacting
R9159 T13635 T13660 themeOf A20,expressed
R9160 T13637 T13662 themeOf A20,target
R9161 T13639 T13663 themeOf ABIN-1,expression
R9162 T13640 T13663 themeOf ABIN-3,expression
R9163 T13642 T13664 themeOf ABIN-1,deficient
R9164 T13643 T13665 themeOf ABIN-2,deficient
R9165 T13644 T13667 themeOf ABIN-3,expressed
R9166 T13645 T13668 themeOf truncated and inactive form,express
R9167 T13645 T13666 themeOf truncated and inactive form,lacking
R9168 T13646 T13670 themeOf A20,inhibits
R9169 T13647 T13670 causeOf ABIN-1,inhibits
R9170 T13648 T13671 themeOf TNF,induced
R9171 T13649 T13669 themeOf ABIN-1,deficient
R9172 T13652 T13672 themeOf TNF,induced
R9173 T13656 T13673 themeOf ABIN-3,expression
R9174 T13657 T13673 themeOf A20,expression
R9175 T13673 T13674 themeOf expression,depend
R9176 T13673 T13674 themeOf expression,depend
R10041 T15045 T15063 themeOf A20,expressed
R10042 T15049 T15064 themeOf CYLD,deficiency
R10043 T15050 T15065 themeOf RANKL,induced
R10044 T15051 T15066 themeOf CYLD,expression
R10045 T15054 T15070 themeOf ubiquitin,binding
R10046 T15055 T15068 themeOf p62,recruited
R10047 T15055 T15070 themeOf p62,binding
R10048 T15058 T15067 themeOf TRAF6,deubiquitination
R10049 T15059 T15071 themeOf p62,expressing
R10050 T15066 T15069 themeOf expression,upregulated
R10665 T16060 T16076 themeOf Single-immunoglobulin IL-1 receptor-related,interaction
R10666 T16061 T16076 themeOf SIGIRR,interaction
R10667 T16062 T16076 themeOf TIR-8,interaction
R10668 T16063 T16076 themeOf IL-1R,interaction
R10669 T16065 T16077 themeOf IRAK1,inhibitor
R10670 T16065 T16076 themeOf IRAK1,interaction
R10671 T16069 T16078 themeOf SIGIRR,expressed
R10672 T16070 T16079 themeOf SIGIRR,overexpression
R10673 T16072 T16080 themeOf SIGIRR,deficient
R10674 T16073 T16081 themeOf SIGIRR,expression
R10675 T16075 T16082 themeOf SIGIRR,target
R10676 T16075 T16083 themeOf SIGIRR,expression
R11281 T17015 T17034 themeOf TRAF1,Expression
R11282 T17016 T17032 causeOf TNF,inducible
R11283 T17017 T17033 themeOf TRAF1,overexpression
R11284 T17020 T17035 themeOf TRAF1,deficient
R11285 T17023 T17036 themeOf TRAF1,deficient
R11286 T17026 T17037 themeOf TRAF1,binding
R11287 T17027 T17039 themeOf TRAF1,recruit
R11288 T17028 T17038 themeOf A20,interact
R11289 T17028 T17039 themeOf A20,recruit
R11290 T17031 T17040 themeOf TRAF1,association
R11291 T17034 T17032 themeOf Expression,inducible
R12357 T18512 T18539 themeOf IL-1β,induced
R12358 T18513 T18539 causeOf TNF,induced
R12359 T18521 T18540 themeOf miR-155,expressed
R12360 T18522 T18541 themeOf miR-146a,overexpressed
R12361 T18524 T18542 themeOf IL-17,producing
R12362 T18525 T18543 themeOf miR-146a,target
R12363 T18526 T18544 themeOf miR-155,overexpression
R12364 T18528 T18545 themeOf TNF,production
R12365 T18531 T18547 themeOf miR-124a,decreased
R12366 T18533 T18549 themeOf miR-203,elevated
R12367 T18534 T18548 themeOf matrix metalloproteinase-1,increased
R12368 T18534 T18550 themeOf matrix metalloproteinase-1,secretion
R12369 T18535 T18548 themeOf IL-6,increased
R12370 T18535 T18550 themeOf IL-6,secretion
R12371 T18545 T18546 themeOf production,promote
R12372 T18550 T18548 themeOf secretion,increased
R12373 T18550 T18548 themeOf secretion,increased
R13674 T20590 T20647 themeOf TNFR1,engagement
R13675 T20591 T20646 themeOf TRIF,recruitment
R13676 T20592 T20646 themeOf RIP1,recruitment
R13677 T20593 T20646 themeOf IRAK1,recruitment
R13678 T20594 T20646 themeOf IRAK4,recruitment
R13679 T20595 T20646 themeOf TRAF2,recruitment
R13680 T20596 T20646 themeOf TRAF6,recruitment
R13681 T20597 T20646 themeOf cIAP1,recruitment
R13682 T20598 T20646 themeOf cIAP2,recruitment
R13683 T20601 T20647 themeOf TLR4,engagement
R13684 T20602 T20646 themeOf TNF receptor 1-associated death domain protein,recruitment
R13685 T20603 T20646 themeOf TRADD,recruitment
R13686 T20604 T20646 themeOf MyD88,recruitment
R13687 T20605 T20646 themeOf MAL,recruitment
R13688 T20606 T20646 themeOf TIR domain-containing adaptor-inducing IFNβ,recruitment
R13689 T20607 T20649 themeOf RIP1,polyubiquitination
R13690 T20608 T20649 themeOf IRAK1,polyubiquitination
R13691 T20610 T20650 themeOf IKK2,recruitment
R13692 T20611 T20650 themeOf TAK1,recruitment
R13693 T20612 T20651 themeOf TAK1,phosphorylates
R13694 T20612 T20652 causeOf TAK1,activates
R13695 T20613 T20651 themeOf IKK2,phosphorylates
R13696 T20613 T20652 themeOf IKK2,activates
R13697 T20614 T20653 themeOf IκBα,phosphorylates
R13698 T20620 T20654 themeOf RIP1,targeting
R13699 T20624 T20656 themeOf IRAK1,expression
R13700 T20625 T20656 themeOf TRAF6,expression
R13701 T20626 T20659 themeOf SIGIRR,inhibited
R13702 T20627 T20657 themeOf TLR4,compete
R13703 T20627 T20658 themeOf TLR4,binding
R13704 T20627 T20658 themeOf TLR4,binding
R13705 T20628 T20658 themeOf IRAK1,binding
R13706 T20629 T20658 themeOf TRAF6,binding
R13707 T20650 T20648 themeOf recruitment,resulting
R13708 T20650 T20648 themeOf recruitment,resulting
R13709 T20656 T20655 themeOf expression,inhibiting
R13710 T20656 T20655 themeOf expression,inhibiting
R13711 T20658 T20657 themeOf binding,compete
R13712 T20658 T20657 themeOf binding,compete
R14446 T22109 T22141 themeOf NF-κB inducing kinase,dependent
R14447 T22109 T22142 themeOf NF-κB inducing kinase,expression
R14448 T22110 T22142 themeOf NIK,expression
R14449 T22111 T22143 themeOf NIK,polyubiquitination
R14450 T22111 T22144 themeOf NIK,degradation
R14451 T22118 T22145 themeOf TRAF3,recruited
R14452 T22120 T22147 themeOf cIAP1,polyubiquitination
R14453 T22120 T22146 themeOf cIAP1,activation
R14454 T22121 T22147 themeOf 2,polyubiquitination
R14455 T22124 T22148 themeOf TRAF3,polyubiquitination
R14456 T22125 T22148 themeOf NIK,polyubiquitination
R14457 T22126 T22149 themeOf TRAF3,degraded
R14458 T22128 T22150 themeOf NIK,increased
R14459 T22129 T22153 themeOf NIK,phosphorylates
R14460 T22129 T22154 causeOf NIK,activates
R14461 T22130 T22153 themeOf IKK1,phosphorylates
R14462 T22130 T22154 themeOf IKK1,activates
R14463 T22130 T22151 causeOf IKK1,mediates
R14464 T22131 T22152 themeOf p100,phosphorylation
R14465 T22132 T22155 themeOf p100,degradation
R14466 T22133 T22155 themeOf p52,degradation
R14467 T22142 T22141 themeOf expression,dependent
R14468 T22142 T22141 themeOf expression,dependent
R14469 T22152 T22151 themeOf phosphorylation,mediates

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue Speculation
T236 23-28 Protein denotes NF-κB
T22486 14491-14508 Protein_catabolism denotes TRAF3 is degraded
T22485 13956-13997 Gene_expression denotes on NF-κB inducing kinase (NIK) expression
T22484 14638-14664 Phosphorylation denotes NF-κB p100 phosphorylation
T22483 14167-14221 Protein_catabolism denotes proteasomal degradation of NIK, keeping NIK levels low
T22482 14228-14252 Binding denotes ligand binding, TRAF3 is
T22481 14417-14450 Binding denotes its K48-linked polyubiquitination
T22480 14720-14767 Protein_catabolism denotes partial proteasomal degradation of p100 to p52,
T22479 14280-14386 Regulation denotes where TRAF2 directs nondegradative K63-linked polyubiquitination of cIAP1/2, resulting in their activation
T22478 14579-14622 Positive_regulation denotes NIK then phosphorylates and activates IKK1,
T22477 14388-14476 Regulation denotes Subsequently cIAP1/2 directs its K48-linked polyubiquitination to TRAF3, rather than NIK
T22476 14623-14664 Regulation denotes which mediates NF-κB p100 phosphorylation
T22475 14513-14530 Regulation denotes NIK is stabilised
T22474 15106-15141 Binding denotes TNF receptor-associated factor; TNF
T22473 15106-15109 Protein denotes TNF
T22472 14989-14993 Protein denotes cIAP
T22471 13907-13997 Protein denotes the noncanonical NF-κB pathway that is dependent on NF-κB inducing kinase (NIK) expression
T22470 14228-14234 Entity denotes ligand
T22469 14760-14767 Protein denotes to p52,
T22468 14794-14803 Protein denotes with RelB
T22467 13959-13986 Protein denotes NF-κB inducing kinase (NIK)
T22466 14491-14496 Protein denotes TRAF3
T22465 14421-14431 Entity denotes K48-linked
T22464 14133-14143 Entity denotes K48-linked
T22463 14401-14408 Protein denotes cIAP1/2
T22462 14579-14582 Protein denotes NIK
T22461 15065-15070 Protein denotes RANK,
T22460 14454-14459 Protein denotes TRAF3
T22459 14009-14027 Entity denotes unstimulated cells
T22458 14960-14979 Protein denotes receptor-associated
T22457 14638-14643 Protein denotes NF-κB
T22456 14839-14844 Protein denotes TRAF3
T22455 14407-14408 Protein denotes 2
T22454 13982-13985 Protein denotes NIK
T22453 14092-14097 Protein denotes TRAF3
T22452 14846-14851 Protein denotes TRAF1
T22451 14401-14408 Protein denotes cIAP1/2
T22450 14569-14577 Entity denotes the cell
T22449 14617-14622 Protein denotes IKK1,
T22448 14348-14386 Protein denotes cIAP1/2, resulting in their activation
T22447 15106-15129 Protein denotes TNF receptor-associated
T22446 15100-15142 Protein denotes TRAF, TNF receptor-associated factor; TNF,
T22445 14752-14759 Protein denotes of p100
T22444 15106-15141 Protein denotes TNF receptor-associated factor; TNF
T22443 14063-14090 Protein denotes the ubiquitin ligases TRAF2
T22442 14102-14110 Protein denotes cIAP1/2,
T22441 14473-14476 Protein denotes NIK
T22440 14038-14110 Entity denotes a cytosolic complex with the ubiquitin ligases TRAF2, TRAF3 and cIAP1/2,
T22439 15045-15165 Protein denotes NF, nuclear factor; RANK, receptor activator of NF-κB; TRAF, TNF receptor-associated factor; TNF, tumour necrosis factor
T22438 14286-14291 Protein denotes TRAF2
T22437 14555-14558 Protein denotes NIK
T22436 14207-14210 Protein denotes NIK
T22435 13889-13893 Protein denotes RANK
T22434 14956-14959 Protein denotes TNF
T22433 14995-15043 Entity denotes cellular inhibitor of apoptosis; IKK, IκB kinase
T22432 15045-15165 Protein denotes NF, nuclear factor; RANK, receptor activator of NF-κB; TRAF, TNF receptor-associated factor; TNF, tumour necrosis factor
T22431 14244-14249 Protein denotes TRAF3
T22430 13880-13884 Protein denotes CD40
T22429 14513-14516 Protein denotes NIK
T22428 14780-14829 Entity denotes a heterodimer with RelB to activate transcription
T22427 14028-14031 Protein denotes NIK
T22426 14191-14221 Protein denotes of NIK, keeping NIK levels low
T22425 14063-14090 Protein denotes the ubiquitin ligases TRAF2
T22424 15017-15043 Protein denotes apoptosis; IKK, IκB kinase
T22423 14638-14648 Protein denotes NF-κB p100
T22422 14266-14279 Protein denotes the receptor,
T22421 14067-14076 Protein denotes ubiquitin
T22420 14686-14696 Entity denotes K48-linked
T22419 14315-14325 Entity denotes K63-linked
T21192 10038-10118 Regulation denotes The expression of many of these negative regulatory molecules is NF-κB dependent
T21191 9914-9960 Negative_regulation denotes inhibited by the transmembrane protein SIGIRR,
T21190 9121-9165 Positive_regulation denotes TAK1 then phosphorylates and activates IKK2,
T21189 9847-9876 Gene_expression denotes expression of IRAK1 and TRAF6
T21188 9847-9876 Gene_expression denotes expression of IRAK1 and TRAF6
T21187 9166-9200 Phosphorylation denotes which in turn phosphorylates IκBα,
T21186 10010-10036 Binding denotes binding to IRAK1 and TRAF6
T21185 9708-9756 Binding denotes specific ubiquitin-binding adaptor proteins such
T21184 10173-10192 Positive_regulation denotes of NF-κB activation
T21183 8950-9005 Ubiquitination denotes K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1,
T21182 8950-9005 Ubiquitination denotes K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1,
T21181 8950-9005 Ubiquitination denotes K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1,
T21180 9471-9488 Positive_regulation denotes NF-κB activation,
T21179 9576-9672 Regulation denotes that control NF-κB activation by targeting specific signalling proteins including RIP1 and TRAF6
T21178 9674-9774 Binding denotes to which they are recruited using specific ubiquitin-binding adaptor proteins such as ABIN-1 and p62
T21177 9447-9532 Regulation denotes can negatively regulate NF-κB activation, most probably by competing with other TRAFs
T21176 9334-9398 Positive_regulation denotes to translocate to the nucleus and promote target gene expression
T21175 9836-9876 Negative_regulation denotes inhibiting expression of IRAK1 and TRAF6
T21174 9836-9876 Negative_regulation denotes inhibiting expression of IRAK1 and TRAF6
T21173 8622-8641 Localization denotes membrane receptors
T21172 10194-10230 Protein denotes ABIN, A20-binding inhibitor of NF-κB
T21171 8779-8784 Protein denotes TRADD
T21170 10053-10099 Entity denotes of many of these negative regulatory molecules
T21169 10336-10455 Protein denotes IRAK, IL-1R-associated kinase; MyD88, myeloid differentiation primary response gene 88; NEMO, NF-κB essential modulator
T21168 10061-10099 Entity denotes of these negative regulatory molecules
T21167 9871-9876 Protein denotes TRAF6
T21166 9115-9119 Protein denotes TAK1
T21165 9760-9766 Protein denotes ABIN-1
T21164 9160-9165 Protein denotes IKK2,
T21163 9708-9756 Protein denotes specific ubiquitin-binding adaptor proteins such
T21162 9924-9952 Protein denotes by the transmembrane protein
T21161 9023-9027 Protein denotes NEMO
T21160 10457-10548 Protein denotes NF, nuclear factor; RANK, receptor activator of NF-κB; RIP1, receptor interacting protein 1
T21159 10194-10199 Protein denotes ABIN,
T21158 10550-10557 Protein denotes SIGIRR,
T21157 10299-10309 Protein denotes IκB kinase
T21156 10639-10662 Protein denotes TNF receptor-associated
T21155 9914-9960 Protein denotes inhibited by the transmembrane protein SIGIRR,
T21154 10021-10026 Protein denotes IRAK1
T21153 9861-9866 Protein denotes IRAK1
T21152 10176-10181 Protein denotes NF-κB
T21151 10336-10341 Protein denotes IRAK,
T21150 8861-8873 Protein denotes RIP1, IRAK1,
T21149 9106-9110 Protein denotes IKK2
T21148 8950-8960 Entity denotes K63-linked
T21147 10424-10429 Protein denotes NEMO,
T21146 9417-9436 Protein denotes no ubiquitin ligase
T21145 8662-8666 Protein denotes RANK
T21144 8649-8654 Protein denotes TNFR1
T21143 9216-9226 Entity denotes K48-linked
T21142 10696-10700 Protein denotes TNF,
T21141 8999-9004 Protein denotes IRAK1
T21140 10336-10455 Protein denotes IRAK, IL-1R-associated kinase; MyD88, myeloid differentiation primary response gene 88; NEMO, NF-κB essential modulator
T21139 8867-8872 Protein denotes IRAK1
T21138 8731-8785 Protein denotes TNF receptor 1-associated death domain protein (TRADD)
T21137 8919-8932 Protein denotes cIAP1, cIAP2)
T21136 9996-10005 Protein denotes with TLR4
T21135 10676-10723 Protein denotes Toll-like receptor; TNF, tumour necrosis factor
T21134 8905-8911 Protein denotes TRAF2,
T21133 9771-9774 Protein denotes p62
T21132 10457-10548 Protein denotes NF, nuclear factor; RANK, receptor activator of NF-κB; RIP1, receptor interacting protein 1
T21131 10367-10373 Protein denotes MyD88,
T21130 10633-10638 Protein denotes TRAF,
T21129 9551-9672 Protein denotes deubiquitinating enzymes that control NF-κB activation by targeting specific signalling proteins including RIP1 and TRAF6
T21128 9321-9324 Protein denotes p65
T21127 8592-8598 Entity denotes Ligand
T21126 8886-8903 Protein denotes ubiquitin ligases
T21125 8852-8881 Protein denotes kinases (RIP1, IRAK1, IRAK4),
T21124 8886-8895 Protein denotes ubiquitin
T21123 10342-10346 Protein denotes IL-1
T21122 10232-10236 Protein denotes cIAP
T21121 9735-9751 Protein denotes adaptor proteins
T21120 9283-9288 Protein denotes NF-κB
T21119 10676-10723 Protein denotes Toll-like receptor; TNF, tumour necrosis factor
T21118 8622-8630 Entity denotes membrane
T21117 8794-8850 Protein denotes MAL, TIR domain-containing adaptor-inducing IFNβ (TRIF))
T21116 8672-8676 Protein denotes TLR4
T21115 9352-9363 Entity denotes the nucleus
T21114 10550-10625 Protein denotes SIGIRR, single-immunoglobulinIL-1 receptor-related; TIR, Toll-like receptor
T21113 10639-10642 Protein denotes TNF
T21112 10512-10517 Protein denotes RIP1,
T21111 10271-10292 Protein denotes CYLD, cylindromatosis
T21110 9195-9200 Protein denotes IκBα,
T21109 8905-8918 Protein denotes TRAF2, TRAF6,
T21108 10329-10334 Protein denotes NF-κB
T21107 10550-10625 Protein denotes SIGIRR, single-immunoglobulinIL-1 receptor-related; TIR, Toll-like receptor
T21106 9471-9476 Protein denotes NF-κB
T21105 9329-9332 Protein denotes p50
T21104 9589-9605 Protein denotes NF-κB activation
T21103 8940-8948 Protein denotes receptor
T21102 9304-9332 Entity denotes a heterodimer of p65 and p50
T21101 8656-8660 Protein denotes CD40
T21100 8799-8849 Protein denotes TIR domain-containing adaptor-inducing IFNβ (TRIF)
T21099 9619-9647 Protein denotes specific signalling proteins
T21098 10626-10630 Protein denotes IL-1
T21097 10316-10334 Entity denotes inhibitor of NF-κB
T21096 9542-9546 Protein denotes CYLD
T21095 9516-9532 Protein denotes with other TRAFs
T21094 8861-8879 Protein denotes RIP1, IRAK1, IRAK4
T21093 9420-9429 Protein denotes ubiquitin
T21092 8926-8931 Protein denotes cIAP2
T21091 10336-10455 Protein denotes IRAK, IL-1R-associated kinase; MyD88, myeloid differentiation primary response gene 88; NEMO, NF-κB essential modulator
T21090 10602-10606 Protein denotes TIR,
T21089 10103-10118 Protein denotes NF-κB dependent
T21088 8990-8994 Protein denotes RIP1
T21087 10271-10276 Protein denotes CYLD,
T21086 9400-9446 Protein denotes TRAF1, which has no ubiquitin ligase activity,
T21085 10336-10455 Protein denotes IRAK, IL-1R-associated kinase; MyD88, myeloid differentiation primary response gene 88; NEMO, NF-κB essential modulator
T21084 9121-9125 Protein denotes TAK1
T21083 8540-8590 Protein denotes Canonical NF-κB signalling and negative regulators
T21082 10238-10256 Entity denotes cellular inhibitor
T21081 9036-9044 Protein denotes proteins
T21080 9776-9783 Entity denotes miR-146
T21079 8844-8848 Protein denotes TRIF
T21078 10477-10482 Protein denotes RANK,
T21077 8622-8640 Protein denotes membrane receptors
T21076 10031-10036 Protein denotes TRAF6
T21075 9667-9672 Protein denotes TRAF6
T21074 8787-8792 Protein denotes MyD88
T21073 9658-9662 Protein denotes RIP1
T21072 8983-8988 Protein denotes TRAFs
T21071 9534-9537 Protein denotes A20
T18867 31029-31120 Gene_expression denotes Notably, both miR-146 and miR-155 are expressed at higher levels in RA synovial fibroblasts
T18866 30542-30568 Protein_catabolism denotes of target mRNA degradation
T18865 31529-31639 Gene_expression denotes cytokine-inducible expression of specific matrix metalloproteinases that mediate tissue destruction in RA [81]
T18864 31559-31639 Regulation denotes of specific matrix metalloproteinases that mediate tissue destruction in RA [81]
T18863 31220-31311 Positive_regulation denotes miR-146a is also overexpressed in CD4+ and IL-17-producing T cells from RA patients [84,85]
T18862 31220-31311 Gene_expression denotes miR-146a is also overexpressed in CD4+ and IL-17-producing T cells from RA patients [84,85]
T18861 31450-31496 Gene_expression denotes miR-155 overexpression in synovial fibroblasts
T18860 31450-31496 Positive_regulation denotes miR-155 overexpression in synovial fibroblasts
T18859 32518-32579 Gene_expression denotes to increased secretion of matrix metalloproteinase-1 and IL-6
T18858 32518-32579 Gene_expression denotes to increased secretion of matrix metalloproteinase-1 and IL-6
T18857 31918-31944 Positive_regulation denotes their increased expression
T18856 30528-30573 Positive_regulation denotes the promotion of target mRNA degradation [77]
T18855 32518-32579 Positive_regulation denotes to increased secretion of matrix metalloproteinase-1 and IL-6
T18854 32518-32579 Positive_regulation denotes to increased secretion of matrix metalloproteinase-1 and IL-6
T18853 30502-30523 Gene_expression denotes of protein expression
T18852 30736-30739 Protein denotes TNF
T18851 31754-31761 Protein denotes miR-155
T18850 32575-32579 Protein denotes IL-6
T18849 32452-32454 Protein denotes RA
T18848 32358-32367 Protein denotes chemokine
T18847 30575-30585 Protein denotes miR-146a/b
T18846 32599-32601 Protein denotes RA
T18845 31220-31228 Protein denotes miR-146a
T18844 31292-31294 Protein denotes RA
T18843 31632-31639 Protein denotes RA [81]
T18842 32140-32147 Entity denotes miR-146
T18841 30786-30801 Protein denotes NF-κB-dependent
T18840 32434-32446 Entity denotes synoviocytes
T18839 31559-31639 Protein denotes of specific matrix metalloproteinases that mediate tissue destruction in RA [81]
T18838 30783-30806 Protein denotes an NF-κB-dependent gene
T18837 32638-32644 Protein denotes miR-16
T18836 30812-30848 Entity denotes the NF-κB signalling molecules IRAK1
T18835 31450-31457 Protein denotes miR-155
T18834 30975-31010 Protein denotes the NF-κB signalling molecules IKKε
T18833 31055-31062 Protein denotes miR-155
T18832 30656-30661 Protein denotes NF-κB
T18831 30878-30918 Protein denotes target genes of miR-146a [78] (Figure 1)
T18830 30975-31010 Entity denotes the NF-κB signalling molecules IKKε
T18829 30853-30858 Protein denotes TRAF6
T18828 30894-30907 Protein denotes miR-146a [78]
T18827 31476-31496 Entity denotes synovial fibroblasts
T18826 31651-31658 Protein denotes miR-155
T18825 31254-31311 Entity denotes CD4+ and IL-17-producing T cells from RA patients [84,85]
T18824 31742-31749 Entity denotes miR-146
T18823 32659-32666 Protein denotes miR-223
T18822 30959-30970 Protein denotes transcripts
T18821 30697-30734 Protein denotes by inflammatory stimuli such as IL-1β
T18820 32324-32332 Protein denotes miR-124a
T18819 32716-32718 Protein denotes RA
T18818 30979-30984 Protein denotes NF-κB
T18817 32544-32570 Protein denotes matrix metalloproteinase-1
T18816 30575-30585 Protein denotes miR-146a/b
T18815 30812-30848 Protein denotes the NF-κB signalling molecules IRAK1
T18814 31380-31384 Protein denotes gene
T18813 30931-30938 Protein denotes miR-155
T18812 31097-31120 Entity denotes RA synovial fibroblasts
T18811 30552-30556 Protein denotes mRNA
T18810 30584-30585 Protein denotes b
T18809 31364-31372 Protein denotes miR-146a
T18808 32268-32280 Protein denotes RA pathology
T18807 31828-31830 Protein denotes RA
T18806 31043-31050 Entity denotes miR-146
T18805 31097-31099 Protein denotes RA
T18804 30324-30327 Protein denotes RNA
T18803 32646-32653 Protein denotes miR-132
T18802 31948-31950 Protein denotes RA
T18801 30590-30597 Protein denotes miR-155
T18800 32611-32627 Entity denotes fibroblasts [90]
T18799 32354-32402 Protein denotes the chemokine monocyte chemoattractant protein 1
T18798 32500-32507 Protein denotes miR-203
T18797 30311-30347 Entity denotes of noncoding RNA molecules essential
T18796 30771-30779 Protein denotes miR-146a
T18795 31015-31019 Protein denotes RIP1
T18794 30816-30821 Protein denotes NF-κB
T18793 32226-32241 Protein denotes NF-κB-dependent
T18792 30463-30573 Protein denotes target mRNAs leading to the repression of protein expression and the promotion of target mRNA degradation [77]
T18791 31164-31218 Entity denotes peripheral blood mononuclear cells of RA patients [83]
T18790 32152-32160 Protein denotes miR-155,
T18789 31733-31735 Protein denotes RA
T18788 31426-31428 Protein denotes RA
T18787 31202-31204 Protein denotes RA
T18786 30505-30512 Protein denotes protein
T19203 32972-32988 Positive_regulation denotes NF-κB activation
T19202 32827-32832 Protein denotes NF-κB
T19201 33145-33165 Protein denotes of the NF-κB pathway
T19200 33334-33365 Protein denotes the multiple mRNAs they target,
T19199 33618-33650 Protein denotes inflammatory diseases such as RA
T19198 32972-32977 Protein denotes NF-κB
T19197 33514-33530 Protein denotes NF-κB signalling
T19196 32918-32920 Protein denotes RA
T17221 29528-29533 Protein denotes TRAF1
T17220 29615-29619 Protein denotes TRAF
T17219 29595-29600 Protein denotes TRAF1
T17218 30057-30062 Protein denotes TRAF1
T17217 29544-29561 Protein denotes NF- κB activation
T17216 29708-29713 Protein denotes TRAF1
T17264 29639-29691 Binding denotes binding to the receptor or other signalling proteins
T17263 29299-29328 Positive_regulation denotes CD40-induced NF-κB activation
T17262 29732-29769 Binding denotes with which it can physically interact true
T17261 29092-29120 Positive_regulation denotes TNF-induced NF-κB activation
T17260 29720-29731 Binding denotes recruit A20
T17259 29015-29034 Gene_expression denotes Expression of TRAF1
T17258 29048-29120 Negative_regulation denotes by TNF and overexpression of TRAF1 inhibits TNF-induced NF-κB activation
T17257 29728-29731 Protein denotes A20
T17256 30203-30215 Protein denotes with RA [76]
T17255 30006-30008 Protein denotes RA
T17254 28862-28867 Protein denotes TRAF1
T17253 29961-29983 Protein denotes complement component 5
T17252 29092-29103 Protein denotes TNF-induced
T17251 28935-28963 Protein denotes certain TNF family receptors
T17250 28943-28946 Protein denotes TNF
T17249 29955-29983 Protein denotes TRAF1-complement component 5
T17248 29312-29317 Protein denotes NF-κB
T17247 28757-28777 Entity denotes a RING finger domain
T17246 28915-28931 Protein denotes NF-κB signalling
T17245 28688-28693 Protein denotes TRAF1
T17244 29077-29082 Protein denotes TRAF1
T17243 29170-29202 Protein denotes TNF, with enhanced proliferation
T17242 29122-29145 Entity denotes TRAF1-deficient T cells
T17241 30190-30195 Protein denotes TRAF1
T17240 29955-29983 Protein denotes TRAF1-complement component 5
T17239 29251-29256 Protein denotes TRAF1
T17238 28720-28724 Protein denotes TRAF
T17237 29889-29891 Protein denotes RA
T17236 28798-28823 Protein denotes ubiquitin ligase activity
T17235 29104-29109 Protein denotes NF-κB
T17234 29426-29441 Protein denotes TRAF2-dependent
T17233 29650-29662 Protein denotes the receptor
T17232 29336-29361 Entity denotes deficient dendritic cells
T17231 29051-29054 Protein denotes TNF
T17230 29299-29311 Protein denotes CD40-induced
T17229 28798-28807 Protein denotes ubiquitin
T17228 29330-29335 Protein denotes TRAF1
T17227 28713-28739 Protein denotes of the TRAF protein family
T17226 28655-28687 Protein denotes TNF receptor-associated factor 1
T17225 29218-29249 Protein denotes of the NF-κB signalling pathway
T17224 29492-29503 Entity denotes these cells
T17223 29026-29034 Protein denotes of TRAF1
T17222 29666-29691 Protein denotes other signalling proteins
T16246 28019-28040 Gene_expression denotes SIGIRR overexpression
T16245 28019-28040 Positive_regulation denotes SIGIRR overexpression
T16244 28009-28138 Negative_regulation denotes Recently, SIGIRR overexpression was shown to inhibit the spontaneous release of inflammatory cytokines by human RA synovial cells
T16243 28009-28138 Negative_regulation denotes Recently, SIGIRR overexpression was shown to inhibit the spontaneous release of inflammatory cytokines by human RA synovial cells
T16242 28062-28138 Regulation denotes the spontaneous release of inflammatory cytokines by human RA synovial cells
T16241 28376-28457 Gene_expression denotes to compare the expression of SIGIRR in RA patients with its expression in control
T16240 27609-27687 Binding denotes direct interaction with these receptors, MyD88, IRAK1 or TRAF6 [67] (Figure 1)
T16239 27854-27882 Negative_regulation denotes a very restricted expression
T16238 28121-28123 Protein denotes RA
T16237 27633-27648 Protein denotes these receptors
T16236 28019-28025 Protein denotes SIGIRR
T16235 27566-27571 Protein denotes IL-1R
T16234 27464-27470 Protein denotes TIR-8,
T16233 27657-27662 Protein denotes IRAK1
T16232 27813-27819 Protein denotes SIGIRR
T16231 27494-27499 Protein denotes IL-1R
T16230 28402-28411 Protein denotes of SIGIRR
T16229 27343-27357 Protein denotes immunoglobulin
T16228 27843-27849 Protein denotes SIGIRR
T16227 27553-27579 Entity denotes inhibitor of IL-1R and TLR
T16226 28307-28323 Entity denotes collagen-induced
T16225 27358-27362 Protein denotes IL-1
T16224 27388-27440 Protein denotes Single-immunoglobulin IL-1 receptor-related (SIGIRR)
T16223 28415-28417 Protein denotes RA
T16222 27943-27968 Entity denotes immature dendritic cells,
T16221 27343-27387 Protein denotes immunoglobulin IL-1 receptor-related protein
T16220 27980-27999 Entity denotes mature macro-phages
T16219 28507-28516 Protein denotes of SIGIRR
T16218 28212-28233 Protein denotes SIGIRR-deficient mice
T16217 28086-28111 Protein denotes of inflammatory cytokines
T16216 27717-27722 Protein denotes IL-1R
T16215 28594-28600 Protein denotes SIGIRR
T16214 27911-27927 Entity denotes epithelial cells
T16213 27358-27379 Protein denotes IL-1 receptor-related
T16212 28112-28138 Entity denotes by human RA synovial cells
T16211 27666-27676 Protein denotes TRAF6 [67]
T16210 28650-28652 Protein denotes RA
T16209 27823-27825 Protein denotes RA
T16208 27782-27789 Protein denotes RA [68]
T16207 28535-28537 Protein denotes RA
T16206 27433-27439 Protein denotes SIGIRR
T16205 27929-27938 Entity denotes monocytes
T16204 28168-28174 Protein denotes SIGIRR
T16203 28269-28284 Entity denotes zymosan-induced
T16202 27650-27655 Protein denotes MyD88
T16201 27388-27448 Protein denotes Single-immunoglobulin IL-1 receptor-related (SIGIRR) protein
T15367 26743-26762 Ubiquitination denotes ubiquitinated TRAF6
T15366 25638-25664 Positive_regulation denotes NF-κB signalling initiated
T15365 26275-26384 Regulation denotes Interestingly, CYLD has been shown to negatively regulate RANK signalling and osteoclastogenesis in mice [65]
T15364 25683-25699 Localization denotes T-cell receptor
T15363 25683-25710 Positive_regulation denotes T-cell receptor stimulation
T15362 26855-26901 Regulation denotes by the CYLD-mediated deubiquitination of TRAF6
T15361 26630-26645 Gene_expression denotes CYLD expression
T15360 25933-25980 Regulation denotes A20 as well as CYLD to control NF-κB activation
T15359 25964-25980 Positive_regulation denotes NF-κB activation
T15358 25612-25710 Regulation denotes that negatively regulates NF-κB signalling initiated by TNFR, RANK and T-cell receptor stimulation
T15357 26690-26703 Protein denotes RANKL-induced
T15356 27106-27119 Protein denotes CYLD-mediated
T15355 26143-26147 Protein denotes CYLD
T15354 25605-25710 Protein denotes enzyme that negatively regulates NF-κB signalling initiated by TNFR, RANK and T-cell receptor stimulation
T15353 26990-26996 Protein denotes of p62
T15352 26499-26534 Entity denotes Osteoclast precursors of these mice
T15351 27308-27333 Protein denotes bone disorders such as RA
T15350 25385-25389 Protein denotes CYLD
T15349 25964-25969 Protein denotes NF-κB
T15348 26071-26083 Protein denotes this protein
T15347 25807-25811 Protein denotes NEMO
T15346 27244-27248 Protein denotes CYLD
T15345 26333-26384 Protein denotes RANK signalling and osteoclastogenesis in mice [65]
T15344 25881-25887 Protein denotes by A20
T15343 26290-26294 Protein denotes CYLD
T15342 25985-25988 Protein denotes A20
T15341 26824-26838 Protein denotes sequestosome 1
T15340 25668-25672 Protein denotes TNFR
T15339 25683-25689 Entity denotes T-cell
T15338 25843-25847 Protein denotes TAK1
T15337 26417-26424 Protein denotes of CYLD
T15336 26010-26025 Entity denotes many cell types
T15335 25238-25261 Protein denotes Cylindromatosis protein
T15334 26893-26901 Protein denotes of TRAF6
T15333 25262-25284 Protein denotes Cylindromatosis (CYLD)
T15332 25745-25796 Protein denotes deubiquitina-ting several NF-κB signalling proteins
T15331 25827-25832 Protein denotes TRAF7
T15330 26743-26762 Protein denotes ubiquitinated TRAF6
T15329 25933-25952 Protein denotes A20 as well as CYLD
T15328 25813-25818 Protein denotes TRAF2
T15327 27135-27164 Protein denotes RANK-induced NF-κB signalling
T15326 26610-26628 Entity denotes larger osteoclasts
T15325 26789-26808 Protein denotes adaptor protein p62
T15324 25279-25283 Protein denotes CYLD
T15323 26386-26424 Protein denotes Mice with a genetic deficiency of CYLD
T15322 27135-27147 Protein denotes RANK-induced
T15321 25238-25253 Protein denotes Cylindromatosis
T15320 26789-26808 Protein denotes adaptor protein p62
T15319 26249-26268 Entity denotes cell-type dependent
T15318 26767-26788 Protein denotes the ubiquitin-binding
T15317 25745-25796 Protein denotes deubiquitina-ting several NF-κB signalling proteins
T15316 25948-25952 Protein denotes CYLD
T15315 25674-25678 Protein denotes RANK
T15314 26630-26634 Protein denotes CYLD
T15313 26114-26133 Protein denotes of NF-κB signalling
T15312 26862-26875 Protein denotes CYLD-mediated
T15311 26559-26564 Protein denotes RANKL
T15310 25834-25838 Protein denotes RIP1
T15309 25820-25825 Protein denotes TRAF6
T15308 25262-25292 Protein denotes Cylindromatosis (CYLD) protein
T15307 25683-25698 Protein denotes T-cell receptor
T15306 25578-25582 Protein denotes CYLD
T15305 25918-25926 Entity denotes the cell
T15304 25638-25643 Protein denotes NF-κB
T15303 26375-26384 Protein denotes mice [65]
T15302 25351-25383 Protein denotes in familial cylindromatosis [63]
T13959 23009-23033 Binding denotes A20 interacting proteins
T13958 23436-23455 Positive_regulation denotes of NF-κB activation
T13957 23696-23736 Gene_expression denotes Functional ABIN-3 is expressed in humans
T13956 24964-24987 Gene_expression denotes autoantibody production
T13955 24475-24540 Gene_expression denotes on the expression of the NF-κB inhibitory proteins ABIN-3 and A20
T13954 24076-24116 Localization denotes TNF-induced genes in human synoviocytes,
T13953 24076-24116 Gene_expression denotes TNF-induced genes in human synoviocytes,
T13952 24076-24116 Positive_regulation denotes TNF-induced genes in human synoviocytes,
T13951 22986-23095 Gene_expression denotes ubiquitously expressed A20 interacting proteins and were shown to inhibit NF-κB activation by TNF and several
T13950 24552-24662 Negative_regulation denotes this protective effect of the ITAM was strongly suppressed in inflammatory arthritis synovial macrophages [60]
T13949 25228-25235 Protein denotes with RA
T13948 22939-22966 Protein denotes TNIP-1, TNIP-2, and TNIP-3)
T13947 23387-23391 Protein denotes ABIN
T13946 24431-24435 Entity denotes ITAM
T13945 23915-23936 Protein denotes ABIN-1 deficient mice
T13944 23329-23344 Protein denotes NF-κB dependent
T13943 24048-24054 Protein denotes ABIN-1
T13942 23009-23033 Protein denotes A20 interacting proteins
T13941 24217-24224 Protein denotes ABIN-1,
T13940 22892-22897 Protein denotes NF-κB
T13939 24380-24436 Entity denotes by immunoreceptor tyrosine-based activation motif (ITAM)
T13938 25060-25069 Entity denotes rituximab
T13937 24280-24299 Protein denotes of NF-κB signalling
T13936 24493-24540 Protein denotes of the NF-κB inhibitory proteins ABIN-3 and A20
T13935 23060-23065 Protein denotes NF-κB
T13934 23080-23083 Protein denotes TNF
T13933 23883-23894 Protein denotes TNF-induced
T13932 24076-24116 Protein denotes TNF-induced genes in human synoviocytes,
T13931 24165-24167 Protein denotes RA
T13930 23962-23975 Protein denotes TNF-dependent
T13929 23379-23399 Entity denotes the A20/ABIN complex
T13928 22898-22904 Protein denotes ABIN-1
T13927 22959-22965 Protein denotes TNIP-3
T13926 24239-24331 Protein denotes A20, in the negative feedback regulation of NF-κB signalling and the pathogenesis of RA [59]
T13925 23292-23295 Protein denotes A20
T13924 23439-23444 Protein denotes NF-κB
T13923 23009-23033 Protein denotes A20 interacting proteins
T13922 23236-23239 Protein denotes A20
T13921 23297-23303 Protein denotes ABIN-1
T13920 22906-22912 Protein denotes ABIN-2
T13919 23243-23279 Entity denotes polyubiquitinated substrates [43,44]
T13918 24537-24540 Protein denotes A20
T13917 24614-24662 Entity denotes inflammatory arthritis synovial macrophages [60]
T13916 23379-23399 Protein denotes the A20/ABIN complex
T13915 24679-24699 Protein denotes ABIN-1 polymorphisms
T13914 24575-24586 Entity denotes of the ITAM
T13913 23580-23585 Protein denotes NF-κB
T13912 23742-23746 Protein denotes mice
T13911 24097-24116 Entity denotes human synoviocytes,
T13910 24136-24147 Protein denotes ABIN-1 mRNA
T13909 23516-23537 Protein denotes ABIN-2-deficient mice
T13908 24436-24454 Protein denotes -coupled receptors
T13907 24526-24532 Protein denotes ABIN-3
T13906 23915-23921 Protein denotes ABIN-1
T13905 22947-22954 Protein denotes TNIP-2,
T13904 24964-24976 Protein denotes autoantibody
T13903 23308-23314 Protein denotes ABIN-3
T13902 23696-23713 Protein denotes Functional ABIN-3
T13901 24136-24142 Protein denotes ABIN-1
T13900 22866-22897 Entity denotes A20-binding inhibitors of NF-κB
T13899 23641-23646 Protein denotes NF-κB
T13898 24076-24087 Protein denotes TNF-induced
T13897 24324-24326 Protein denotes RA
T13896 24500-24505 Protein denotes NF-κB
T13895 23810-23839 Entity denotes ubiquitin-binding domain [57]
T13894 25042-25048 Entity denotes B-cell
T13893 23762-23789 Protein denotes truncated and inactive form
T13892 22917-22923 Protein denotes ABIN-3
T13891 24854-24856 Protein denotes RA
T13890 24005-24046 Entity denotes Using oligonucleotide microarray analysis
T13889 23853-23859 Protein denotes ABIN-1
T12419 18038-18069 Regulation denotes NF-κB-dependent gene expression
T12418 19684-19747 Localization denotes a major antiapoptotic protein in the intestinal epithelium [47]
T12417 18734-18809 Regulation denotes The association of A20 with its targets requires specific ubiquitin-binding
T12416 21162-21180 Gene_expression denotes A20 overexpression
T12415 21162-21180 Positive_regulation denotes A20 overexpression
T12414 20106-20120 Gene_expression denotes A20 expression
T12413 20141-20171 Gene_expression denotes by NF-κB [50], implicating A20
T12412 21783-21820 Binding denotes a clear association between mutations
T12411 22545-22572 Negative_regulation denotes repressed A20 transcription
T12410 20499-20513 Gene_expression denotes A20 expression
T12409 18783-18809 Binding denotes specific ubiquitin-binding
T12408 18934-18963 Negative_regulation denotes suppressing NF-κB activation,
T12407 21451-21566 Localization denotes that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells
T12406 22534-22572 Transcription denotes could show repressed A20 transcription
T12405 18734-18756 Binding denotes The association of A20
T12404 18946-18962 Positive_regulation denotes NF-κB activation
T12403 20567-20572 Protein denotes NF-κB
T12402 22507-22519 Entity denotes A20 promoter
T12401 21162-21165 Protein denotes A20
T12400 22290-22292 Protein denotes RA
T12399 20618-20622 Protein denotes IL-6
T12398 22832-22834 Protein denotes RA
T12397 22359-22361 Protein denotes RA
T12396 20397-20413 Entity denotes collagen-induced
T12395 18337-18373 Protein denotes specific NF-κB signalling molecules,
T12394 21982-21985 Protein denotes A20
T12393 21944-21950 Protein denotes a gene
T12392 18810-18912 Protein denotes adaptor proteins, including A20-binding inhibitor of NF-κB (ABIN) 1 and Tax1-binding protein 1 [43-46]
T12391 17972-17979 Protein denotes TNFAIP3
T12390 18882-18912 Protein denotes Tax1-binding protein 1 [43-46]
T12389 20861-20864 Protein denotes TNF
T12388 19872-19879 Entity denotes B cells
T12387 21531-21546 Entity denotes dendritic cells
T12386 18302-18307 Protein denotes NF-κB
T12385 22507-22510 Protein denotes A20
T12384 18388-18392 Protein denotes RIP2
T12383 20698-20706 Protein denotes that A20
T12382 18577-18583 Protein denotes Ubc5hc
T12381 18382-18386 Protein denotes RIP1
T12380 19606-19639 Entity denotes their intestinal epithelial cells
T12379 20208-20216 Protein denotes of NF-κB
T12378 18628-18635 Protein denotes cIAP1/2
T12377 19250-19278 Entity denotes the potent anti-inflammatory
T12376 19853-19858 Protein denotes NF-κB
T12375 19360-19372 Protein denotes TNF-mediated
T12374 20606-20610 Protein denotes TNF,
T12373 22220-22222 Protein denotes RA
T12372 19311-19314 Protein denotes A20
T12371 20996-20999 Protein denotes TNF
T12370 18618-18623 Protein denotes TRAF2
T12369 18146-18154 Entity denotes antigens
T12368 18533-18584 Protein denotes E2 ubiquitin conjugating enzymes (Ubc13 and Ubc5hc)
T12367 18589-18636 Protein denotes E3 ubiquitin ligases (TRAF6, TRAF2 and cIAP1/2)
T12366 19684-19747 Protein denotes a major antiapoptotic protein in the intestinal epithelium [47]
T12365 18187-18225 Protein denotes the nucleotide-binding oligomerisation
T12364 20078-20089 Entity denotes lymphocytes
T12363 18226-18254 Protein denotes domain-containing 2 receptor
T12362 18964-18967 Protein denotes A20
T12361 18137-18141 Protein denotes IL-1
T12360 19062-19065 Protein denotes A20
T12359 19904-19910 Entity denotes B-cell
T12358 18038-18053 Protein denotes NF-κB-dependent
T12357 17984-18011 Protein denotes a ubiquitin-editing protein
T12356 19798-19801 Protein denotes A20
T12355 19780-19789 Protein denotes that mice
T12354 22116-22119 Protein denotes A20
T12353 21989-22005 Protein denotes its nearest gene
T12352 20168-20171 Protein denotes A20
T12351 18589-18636 Protein denotes E3 ubiquitin ligases (TRAF6, TRAF2 and cIAP1/2)
T12350 18634-18635 Protein denotes 2
T12349 22327-22330 Protein denotes A20
T12348 21607-21610 Protein denotes A20
T12347 20048-20059 Entity denotes fibroblasts
T12346 18750-18756 Protein denotes of A20
T12345 21215-21239 Entity denotes of activated osteoclasts
T12344 19126-19144 Protein denotes A20-deficient mice
T12343 19407-19431 Protein denotes an antiapoptotic protein
T12342 21518-21529 Entity denotes macrophages
T12341 17953-17956 Protein denotes A20
T12340 19021-19036 Entity denotes some cell types
T12339 17941-17944 Protein denotes A20
T12338 20036-20038 Protein denotes RA
T12337 18976-19008 Entity denotes a strong inhibitor of apoptosis,
T12336 19315-19330 Entity denotes deficient cells
T12335 18946-18951 Protein denotes NF-κB
T12334 19929-19932 Protein denotes A20
T12333 21446-21450 Protein denotes mice
T12332 20869-20874 Protein denotes IL-1β
T12331 18628-18635 Protein denotes cIAP1/2
T12330 21451-21566 Protein denotes that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells
T12329 20793-20809 Protein denotes NF-κB activation
T12328 18567-18572 Protein denotes Ubc13
T12327 22029-22032 Protein denotes A20
T12326 18792-18801 Protein denotes ubiquitin
T12325 21468-21516 Entity denotes specific cell types such as synovial fibroblasts
T12324 20738-20754 Entity denotes collagen-induced
T12323 20144-20155 Protein denotes NF-κB [50],
T12322 20765-20769 Protein denotes mice
T12321 21883-21890 Protein denotes RA [52]
T12320 22246-22249 Protein denotes A20
T12319 22474-22490 Entity denotes of RA-associated
T12318 18337-18373 Entity denotes specific NF-κB signalling molecules,
T12317 20639-20675 Protein denotes monocyte chemo-attractant protein 1,
T12316 20499-20502 Protein denotes A20
T12315 22183-22222 Protein denotes the primary inflammatory cytokine in RA
T12314 21559-21566 Entity denotes T cells
T12313 19452-19461 Protein denotes that mice
T12312 21468-21495 Entity denotes specific cell types such as
T12311 19677-19680 Protein denotes A20
T12310 20061-20073 Entity denotes synoviocytes
T12309 21257-21260 Protein denotes A20
T12308 19805-19812 Entity denotes B cells
T12307 19643-19654 Protein denotes TNF-induced
T12306 18688-18694 Protein denotes by A20
T12305 21004-21032 Protein denotes IL-1β in A20-transduced mice
T12304 19483-19486 Protein denotes A20
T12303 19490-19517 Entity denotes intestinal epithelial cells
T12302 19965-20039 Entity denotes several cell types that play important roles in the pathophysiology of RA,
T12301 18711-18716 Protein denotes NF-κB
T12300 18611-18616 Protein denotes TRAF6
T12299 20606-20623 Protein denotes TNF, IL-1β, IL-6,
T12298 21824-21831 Protein denotes the A20
T12297 18394-18399 Protein denotes TRAF6
T12296 18275-18278 Protein denotes A20
T12295 18132-18135 Protein denotes TNF
T12294 20962-20965 Protein denotes RA,
T12293 19288-19309 Entity denotes of this molecule [46]
T12292 22151-22162 Protein denotes TNF-induced
T12291 22084-22087 Entity denotes DNA
T12290 21841-21860 Entity denotes the 6q23 chromosome
T12289 20106-20109 Protein denotes A20
T12288 22791-22794 Protein denotes A20
T12287 21013-21032 Protein denotes A20-transduced mice
T12286 21548-21555 Entity denotes B cells
T12285 18838-18877 Protein denotes A20-binding inhibitor of NF-κB (ABIN) 1
T12284 20459-20473 Entity denotes a prophylactic
T12283 22555-22558 Protein denotes A20
T12282 22176-22179 Protein denotes TNF
T12281 21323-21344 Entity denotes the osteoclast number
T12280 18404-18410 Protein denotes MALT1,
T12279 20632-20686 Protein denotes RANKL, monocyte chemo-attractant protein 1, and IL-17,
T12278 17941-17952 Protein denotes A20 protein
T12277 20268-20285 Protein denotes an A20-expressing
T12276 20680-20685 Protein denotes IL-17
T9339 17705-17741 Regulation denotes regulation of the noncanonical NF-κB
T9338 17580-17606 Phosphorylation denotes phosphorylating STAT1 [35]
T9337 17457-17473 Protein_catabolism denotes IκBα degradation
T9336 15968-15984 Positive_regulation denotes NF-κB activation
T9335 17428-17452 Positive_regulation denotes enhanced IKK2 activation
T9334 17508-17529 Negative_regulation denotes inhibit nuclear NF-κB
T9333 17333-17357 Gene_expression denotes expressing inactive IKK1
T9332 16234-16261 Positive_regulation denotes persistent NF-κB activation
T9331 16605-16625 Regulation denotes the control of NF-κB
T9330 17608-17704 Phosphorylation denotes Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback
T9329 17428-17452 Positive_regulation denotes enhanced IKK2 activation
T9328 17363-17383 Positive_regulation denotes increased production
T9327 16226-16261 Negative_regulation denotes prevent persistent NF-κB activation
T9326 16402-16461 Protein denotes inhibitory proteins that downregulate NF-κB signalling [32]
T9325 16570-16575 Protein denotes NF-κB
T9324 17297-17301 Protein denotes IKK1
T9323 16847-16862 Protein denotes NF-κB-dependent
T9322 17823-17938 Protein denotes both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA
T9321 17162-17173 Protein denotes this kinase
T9320 17312-17316 Protein denotes mice
T9319 17344-17357 Protein denotes inactive IKK1
T9318 17069-17073 Protein denotes IKK1
T9317 17776-17785 Protein denotes that IKK1
T9316 17596-17606 Protein denotes STAT1 [35]
T9315 17936-17938 Protein denotes RA
T9314 16903-16909 Protein denotes IRAK-M
T9313 17660-17664 Protein denotes IKK1
T9312 16778-16783 Protein denotes of RA
T9311 17457-17461 Protein denotes IκBα
T9310 16049-16077 Protein denotes the NF-κB signalling pathway
T9309 16195-16200 Protein denotes NF-κB
T9308 17680-17683 Protein denotes NIK
T9307 16245-16250 Protein denotes NF-κB
T9306 15968-15973 Protein denotes NF-κB
T9305 17437-17441 Protein denotes IKK2
T9304 16339-16344 Entity denotes cells
T9303 16617-16625 Protein denotes of NF-κB
T9302 16895-16901 Protein denotes MyD88s
T9301 17280-17301 Entity denotes Macrophages from IKK1
T9300 17716-17741 Protein denotes of the noncanonical NF-κB
T9299 16082-16102 Protein denotes the genes it induces
T9298 17480-17484 Protein denotes IKK1
T9297 16785-16886 Protein denotes Several other proteins involved in the negative regulation of NF-κB-dependent inflammatory responses,
T9296 17098-17133 Protein denotes of the non-canonical NF-κB pathway,
T9295 17020-17032 Protein denotes RA pathology
T9294 17229-17278 Protein denotes of both canonical and noncanonical NF-κB pathways
T9293 16915-16921 Protein denotes TOLLIP
T9292 17516-17529 Protein denotes nuclear NF-κB
T9291 16501-16512 Protein denotes of proteins
T9290 16440-16461 Protein denotes NF-κB signalling [32]
T8206 11994-12032 Positive_regulation denotes TLR4 stimulation by lipopolysaccharide
T8205 15323-15346 Binding denotes binding of their ligand
T8204 8077-8107 Regulation denotes which mediates phosphorylation
T8203 13657-13689 Protein_catabolism denotes for subsequent TRAF3 degradation
T8202 13777-13793 Binding denotes NIK accumulation
T8201 15201-15316 Regulation denotes lymphotoxin β receptor and RANK mediate the activation of both canonical and noncanonical NF-κB signalling pathways
T8200 15201-15316 Regulation denotes lymphotoxin β receptor and RANK mediate the activation of both canonical and noncanonical NF-κB signalling pathways
T8199 11676-11710 Positive_regulation denotes for TNF-activated NF-κB signalling
T8198 15747-15775 Regulation denotes CD40-mediated JNK activation
T8197 15825-15845 Positive_regulation denotes activation of NF-κB,
T8196 15635-15689 Binding denotes associated with overlapping and distinct CD40-mediated
T8195 11572-11710 Regulation denotes of a distinct E2/E3 enzyme complex that modifies NEMO with linear polyubiquitin chains and is essential for TNF-activated NF-κB signalling
T8194 11444-11530 Binding denotes to recruit the IKK and TAK1 complex via the ubiquitin-binding proteins NEMO and TAB1/2
T8193 13798-13818 Phosphorylation denotes IKK1 phosphorylation
T8192 12209-12345 Binding denotes to recruit myeloid differentiation primary response gene 88 (MyD88) and TIR domain-containing adaptor-inducing IFNβ (TRIF), respectively
T8191 7399-7435 Positive_regulation denotes NF-κB transactivation in the nucleus
T8190 13567-13580 Binding denotes recruiting it
T8189 12469-12497 Ubiquitination denotes ubiquitination of TRAF6 [24]
T8188 13637-13689 Regulation denotes which are essential for subsequent TRAF3 degradation
T8187 11308-11328 Ubiquitination denotes RIP1 ubiquitination,
T8186 11167-11182 Positive_regulation denotes TNF stimulation
T8185 15717-15731 Localization denotes B cells TRAF6
T8184 13607-13636 Binding denotes to attract TRAF2 and cIAP1/2,
T8183 10795-10810 Positive_regulation denotes TNF stimulation
T8182 12504-12567 Binding denotes also recruits TRAF6 [25] and RIP1 [26] via a direct interaction
T8181 15780-15796 Gene_expression denotes IL-6 production,
T8180 8497-8528 Positive_regulation denotes canonical NF-κB activation [21]
T8179 11057-11151 Binding denotes which in turn bind the E3 ubiquitin ligases cellular inhibitor of apoptosis (cIAP) 1 and cIAP2
T8178 11057-11151 Binding denotes which in turn bind the E3 ubiquitin ligases cellular inhibitor of apoptosis (cIAP) 1 and cIAP2
T8177 15747-15775 Positive_regulation denotes CD40-mediated JNK activation
T8176 7365-7435 Positive_regulation denotes IκBξ and Bcl-3 instead potentiate NF-κB transactivation in the nucleus
T8175 7365-7435 Positive_regulation denotes IκBξ and Bcl-3 instead potentiate NF-κB transactivation in the nucleus
T8174 7024-7114 Binding denotes NF-κB proteins are sequestered in the cytoplasm as latent complexes by inhibitory proteins
T8173 13530-13597 Negative_regulation denotes to remove TRAF3 from this complex by recruiting it to the receptor,
T8172 13712-13728 Regulation denotes to releasing NIK
T8171 11184-11207 Binding denotes TNF-receptor bound RIP1
T8170 11498-11514 Binding denotes binding proteins
T8169 10819-10895 Binding denotes in the recruitment of TNF receptor-1-associated death domain (TRADD) protein
T8168 12041-12094 Binding denotes the recruitment of Toll/IL-1 receptor adaptor protein
T8167 11076-11141 Protein denotes the E3 ubiquitin ligases cellular inhibitor of apoptosis (cIAP) 1
T8166 12863-12867 Protein denotes p52,
T8165 8313-8317 Protein denotes IKKβ
T8164 8412-8438 Protein denotes Gene targeting experiments
T8163 8304-8308 Protein denotes IKKα
T8162 7854-7903 Protein denotes NF-κB signalling initiated by different receptors
T8161 12597-12601 Protein denotes TAK1
T8160 13378-13383 Protein denotes TRAF3
T8159 11498-11514 Protein denotes binding proteins
T8158 7259-7263 Protein denotes IκBα
T8157 8460-8464 Protein denotes NEMO
T8156 13469-13486 Entity denotes by the proteasome
T8155 11184-11202 Protein denotes TNF-receptor bound
T8154 8149-8175 Entity denotes its K48-polyubiquitination
T8153 11776-11789 Protein denotes polyubiquitin
T8152 15190-15199 Protein denotes that CD40
T8151 13777-13780 Protein denotes NIK
T8150 7374-7379 Protein denotes Bcl-3
T8149 12385-12389 Protein denotes IL-1
T8148 7768-7818 Protein denotes proinflammatory cytokines (for example, TNF, IL-1)
T8147 7830-7835 Protein denotes RANKL
T8146 8044-8076 Entity denotes of the IκB kinase (IKK) complex,
T8145 11455-11479 Entity denotes the IKK and TAK1 complex
T8144 15384-15388 Protein denotes TRAF
T8143 13290-13305 Entity denotes most cell types
T8142 11621-11625 Protein denotes NEMO
T8141 12220-12276 Protein denotes myeloid differentiation primary response gene 88 (MyD88)
T8140 7179-7184 Protein denotes NF-κB
T8139 11680-11693 Protein denotes TNF-activated
T8138 15440-15445 Protein denotes TRAF6
T8137 10841-10887 Protein denotes TNF receptor-1-associated death domain (TRADD)
T8136 15607-15630 Entity denotes Specific TRAF molecules
T8135 11276-11283 Protein denotes cIAP1/2
T8134 7983-8000 Protein denotes receptor specific
T8133 12156-12160 Protein denotes TRAM
T8132 12741-12754 Protein denotes lymphotoxin β
T8131 11484-11519 Protein denotes the ubiquitin-binding proteins NEMO
T8130 10795-10798 Protein denotes TNF
T8129 11276-11283 Protein denotes cIAP1/2
T8128 13179-13182 Protein denotes NIK
T8127 7237-7281 Protein denotes the majority of IκBs (IκBα, IκBβ, IκBε, p105
T8126 10988-10997 Protein denotes ubiquitin
T8125 10935-10939 Protein denotes RIP1
T8124 10838-10895 Protein denotes of TNF receptor-1-associated death domain (TRADD) protein
T8123 7024-7038 Protein denotes NF-κB proteins
T8122 11529-11530 Protein denotes 2
T8121 7481-7484 Protein denotes p50
T8120 7326-7332 Protein denotes NF-κB2
T8119 11488-11514 Protein denotes ubiquitin-binding proteins
T8118 11964-11979 Protein denotes other receptors
T8117 12518-12528 Protein denotes TRAF6 [25]
T8116 13389-13396 Protein denotes cIAP1/2
T8115 10981-11045 Protein denotes the E3 ubiquitin ligases TNF receptor-associated factor (TRAF) 2
T8114 7808-7812 Protein denotes TNF,
T8113 7820-7828 Entity denotes antigens
T8112 13488-13496 Protein denotes Receptor
T8111 15803-15808 Protein denotes TRAF2
T8110 7446-7450 Protein denotes p105
T8109 11167-11170 Protein denotes TNF
T8108 8474-8478 Protein denotes IKK1
T8107 7058-7071 Entity denotes the cytoplasm
T8106 15228-15232 Protein denotes RANK
T8105 12445-12460 Protein denotes oligomerisation
T8104 15489-15494 Protein denotes TRAF2
T8103 12703-12716 Protein denotes NF-κB pathway
T8102 7536-7569 Protein denotes NF-κB signalling pathways, termed
T8101 12842-12867 Entity denotes by the proteasome to p52,
T8100 15422-15427 Protein denotes TRAF3
T8099 12326-12330 Protein denotes TRIF
T8098 8507-8512 Protein denotes NF-κB
T8097 11270-11271 Protein denotes 5
T8096 13546-13563 Entity denotes from this complex
T8095 11231-11241 Entity denotes K63-linked
T8094 12402-12415 Protein denotes kinase (IRAK)
T8093 13310-13328 Entity denotes unstimulated cells
T8092 12011-12032 Entity denotes by lipopolysaccharide
T8091 13584-13597 Protein denotes the receptor,
T8090 7024-7029 Protein denotes NF-κB
T8089 8284-8288 Protein denotes IKK2
T8088 11488-11514 Protein denotes ubiquitin-binding proteins
T8087 11308-11312 Protein denotes RIP1
T8086 15331-15346 Entity denotes of their ligand
T8085 10749-10774 Protein denotes NF-κB signalling pathways
T8084 12427-12433 Protein denotes TRAF6,
T8083 11524-11530 Protein denotes TAB1/2
T8082 13051-13081 Protein denotes The noncanonical NF-κB pathway
T8081 11405-11409 Protein denotes RIP1
T8080 11264-11271 Protein denotes TRAF2/5
T8079 12897-12902 Protein denotes NF-κB
T8078 8192-8209 Entity denotes by the proteasome
T8077 15348-15352 Protein denotes CD40
T8076 8224-8231 Entity denotes complex
T8075 13185-13188 Protein denotes NIK
T8074 13371-13376 Protein denotes TRAF2
T8073 7437-7441 Protein denotes p100
T8072 11902-11923 Protein denotes the TAK1 complex [23]
T8071 12780-12784 Protein denotes CD40
T8070 15890-15913 Protein denotes CD40 signalling [30,31]
T8069 13672-13677 Protein denotes TRAF3
T8068 12765-12778 Protein denotes BAFF receptor
T8067 15717-15724 Entity denotes B cells
T8066 8373-8398 Protein denotes NEMO - also known as IKKγ
T8065 13330-13333 Protein denotes NIK
T8064 12533-12537 Protein denotes RIP1
T8063 12737-12763 Protein denotes the lymphotoxin β receptor
T8062 10903-10941 Protein denotes receptor interacting protein 1 (RIP1),
T8061 8248-8279 Protein denotes the two catalytic subunits IKK1
T8060 10981-11045 Protein denotes the E3 ubiquitin ligases TNF receptor-associated factor (TRAF) 2
T8059 12790-12794 Protein denotes RANK
T8058 7947-7954 Protein denotes protein
T8057 15635-15689 Protein denotes associated with overlapping and distinct CD40-mediated
T8056 11902-11923 Entity denotes the TAK1 complex [23]
T8055 7645-7672 Protein denotes The canonical NF-κB pathway
T8054 15357-15361 Protein denotes RANK
T8053 7808-7817 Protein denotes TNF, IL-1
T8052 13389-13396 Protein denotes cIAP1/2
T8051 7344-7364 Entity denotes inhibitors of NF-κB,
T8050 11083-11092 Protein denotes ubiquitin
T8049 15616-15620 Protein denotes TRAF
T8048 15415-15420 Protein denotes TRAF2
T8047 7473-7476 Protein denotes p52
T8046 11859-11872 Protein denotes polyubiquitin
T7969 10778-10793 Protein denotes the TNF pathway
T7968 11572-11710 Protein denotes of a distinct E2/E3 enzyme complex that modifies NEMO with linear polyubiquitin chains and is essential for TNF-activated NF-κB signalling
T8045 7399-7404 Protein denotes NF-κB
T8044 7629-7643 Protein denotes NF-κB pathways
T8043 12824-12828 Protein denotes p100
T8042 11676-11710 Protein denotes for TNF-activated NF-κB signalling
T8041 11242-11255 Protein denotes polyubiquitin
T8040 8130-8214 Protein denotes protein leading to its K48-polyubiquitination and degradation by the proteasome [20]
T8039 15201-15223 Protein denotes lymphotoxin β receptor
T8038 11994-11998 Protein denotes TLR4
T8037 15717-15730 Protein denotes B cells TRAF6
T8036 8044-8076 Protein denotes of the IκB kinase (IKK) complex,
T8035 7130-7164 Entity denotes inhibitor of NF-κB (IκB) proteins,
T8034 8323-8399 Protein denotes the regulatory subunit NF-κB essential modulator (NEMO - also known as IKKγ)
T8033 7297-7303 Protein denotes NF-κB1
T8032 15201-15214 Protein denotes lymphotoxin β
T8031 12499-12503 Protein denotes TRIF
T8030 7143-7163 Protein denotes NF-κB (IκB) proteins
T8029 13725-13728 Protein denotes NIK
T8028 13628-13636 Protein denotes cIAP1/2,
T8027 13540-13545 Protein denotes TRAF3
T8026 12270-12275 Protein denotes MyD88
T8025 11467-11471 Protein denotes TAK1
T8024 11050-11056 Protein denotes TRAF5,
T8023 13618-13623 Protein denotes TRAF2
T8022 7271-7275 Protein denotes IκBε
T8021 15499-15504 Protein denotes TRAF3
T8020 11638-11651 Protein denotes polyubiquitin
T8019 12484-12497 Protein denotes of TRAF6 [24]
T8018 15836-15844 Protein denotes of NF-κB
T8017 12655-12684 Protein denotes to the TNF pathway (Figure 1)
T8016 7481-7490 Protein denotes p50 NF-κB
T8015 11076-11141 Protein denotes the E3 ubiquitin ligases cellular inhibitor of apoptosis (cIAP) 1
T8014 11282-11283 Protein denotes 2
T8013 13798-13802 Protein denotes IKK1
T8012 11524-11530 Protein denotes TAB1/2
T8011 15780-15784 Protein denotes IL-6
T8010 7881-7903 Protein denotes by different receptors
T8009 10968-11056 Protein denotes proteins for the E3 ubiquitin ligases TNF receptor-associated factor (TRAF) 2 and TRAF5,
T8008 8394-8398 Protein denotes IKKγ
T8007 7143-7154 Protein denotes NF-κB (IκB)
T8006 8446-8455 Protein denotes that IKK2
T8005 7358-7363 Protein denotes NF-κB
T8004 11184-11202 Protein denotes TNF-receptor bound
T8003 12410-12414 Protein denotes IRAK
T8002 7095-7114 Protein denotes inhibitory proteins
T8001 13153-13183 Protein denotes by NF-κB inducing kinase (NIK)
T8000 12939-12984 Protein denotes target genes that control B-cell development,
T7999 12347-12352 Protein denotes MyD88
T7998 7927-8000 Protein denotes of proximal protein-protein interactions that are often receptor specific
T7997 13395-13396 Protein denotes 2
T7996 12125-12162 Protein denotes TRIF-related adaptor molecule (TRAM),
T7995 15429-15434 Protein denotes TRAF5
T7994 13344-13365 Entity denotes a cytoplasmic complex
T7993 12765-12769 Protein denotes BAFF
T7992 7306-7310 Protein denotes p100
T7991 12281-12331 Protein denotes TIR domain-containing adaptor-inducing IFNβ (TRIF)
T7990 13104-13112 Protein denotes on IKK1,
T7989 12057-12094 Protein denotes of Toll/IL-1 receptor adaptor protein
T7988 11184-11207 Protein denotes TNF-receptor bound RIP1
T7987 15761-15764 Protein denotes JNK
T7986 7365-7369 Protein denotes IκBξ
T7985 7265-7276 Protein denotes IκBβ, IκBε,
T7984 11264-11271 Protein denotes TRAF2/5
T7983 11146-11151 Protein denotes cIAP2
T7982 12116-12119 Protein denotes Mal
T7981 15850-15855 Protein denotes TRAF3
T7980 7075-7114 Entity denotes latent complexes by inhibitory proteins
T7979 15747-15760 Protein denotes CD40-mediated
T7978 11572-11710 Entity denotes of a distinct E2/E3 enzyme complex that modifies NEMO with linear polyubiquitin chains and is essential for TNF-activated NF-κB signalling
T7977 15256-15316 Protein denotes of both canonical and noncanonical NF-κB signalling pathways
T7976 10881-10886 Protein denotes TRADD
T7975 15408-15413 Protein denotes TRAF1
T7974 11759-11775 Protein denotes protein-anchored
T7973 7424-7435 Entity denotes the nucleus
T7972 7841-7852 Entity denotes TLR ligands
T7971 12965-12971 Entity denotes B-cell
T7970 11381-11394 Protein denotes polyubiquitin
T3698 6929-6945 Positive_regulation denotes NF-κB activation
T3697 4207-4242 Binding denotes Binding of the CD40 ligand (CD154),
T3696 5406-5432 Gene_expression denotes proteins derived from host
T3695 4325-4351 Positive_regulation denotes NF-κB activation resulting
T3694 3394-3430 Regulation denotes an effective treatment for severe RA
T3693 3644-3729 Positive_regulation denotes NF-κB activation by receptor activator of NF-κB (RANK), a TNF receptor family member,
T3692 5154-5237 Gene_expression denotes Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases
T3691 5613-5639 Entity denotes various endogenous ligands
T3690 4215-4242 Entity denotes of the CD40 ligand (CD154),
T3689 3702-3705 Protein denotes TNF
T3688 5589-5591 Protein denotes RA
T3665 6341-6367 Protein denotes myeloid-related protein 14
T3664 4118-4133 Entity denotes dendritic cells
T3663 6004-6018 Entity denotes by macrophages
T3662 6099-6103 Protein denotes TLR4
T3661 3282-3319 Protein denotes proinflammatory cytokines such as TNF
T3660 6736-6747 Protein denotes fibronectin
T3659 3552-3567 Protein denotes these cytokines
T3658 3498-3503 Protein denotes NF-κB
T3657 4101-4134 Entity denotes macrophages, and dendritic cells,
T3656 3923-3931 Protein denotes receptor
T3655 4076-4090 Entity denotes synovial cells
T3654 6775-6791 Entity denotes hyal-uronic acid
T3653 6982-6984 Protein denotes RA
T3652 5738-5742 Protein denotes mice
T3651 4957-4961 Protein denotes BAFF
T3650 6183-6212 Entity denotes HMGB1 neutralising antibodies
T3649 6311-6336 Protein denotes Myeloid-related protein 8
T3648 5475-5495 Entity denotes candidate activators
T3647 5682-5684 Protein denotes RA
T3646 5406-5432 Protein denotes proteins derived from host
T3645 6929-6934 Protein denotes NF-κB
T3644 3156-3158 Protein denotes RA
T3643 6160-6162 Protein denotes RA
T3642 4427-4438 Protein denotes chemokines,
T3641 4836-4840 Protein denotes BAFF
T3640 6504-6506 Protein denotes RA
T3639 4057-4059 Protein denotes RA
T3638 5954-5963 Entity denotes chromatin
T3637 6724-6734 Protein denotes fibrinogen
T3636 3450-3453 Protein denotes TNF
T3635 3706-3714 Protein denotes receptor
T3634 6749-6757 Protein denotes biglycan
T3633 4705-4726 Entity denotes pathogenic antibodies
T3632 4501-4523 Protein denotes antagonistic anti-CD40
T3631 4073-4075 Protein denotes RA
T3630 3458-3462 Protein denotes IL-1
T3629 5331-5349 Entity denotes microbial ligands,
T3628 3686-3698 Protein denotes NF-κB (RANK)
T3627 6236-6253 Entity denotes A domain of HMGB1
T3626 6300-6309 Protein denotes mice [16]
T3625 6121-6136 Protein denotes in RA pathology
T3624 6447-6471 Protein denotes calcium-binding proteins
T3623 3244-3249 Protein denotes NF-κB
T3622 5312-5314 Protein denotes RA
T3621 4015-4040 Entity denotes smooth muscle fibroblasts
T3620 6684-6723 Entity denotes extracellular matrix components such as
T3619 5499-5543 Protein denotes TLRs inducing so-called sterile inflammation
T3618 4865-4880 Protein denotes of autoantibody
T3617 6063-6136 Entity denotes one of the most putative endogenous TLR4 ligands involved in RA pathology
T3616 3375-3390 Entity denotes TNF antagonists
T3615 3919-3922 Protein denotes TNF
T3614 6428-6472 Protein denotes the S100 family of calcium-binding proteins,
T3613 6183-6212 Protein denotes HMGB1 neutralising antibodies
T3612 6270-6286 Entity denotes collagen-induced
T3611 3282-3315 Protein denotes proinflammatory cytokines such as
T3610 4776-4816 Entity denotes of the TNF receptor family member B-cell
T3609 4571-4580 Protein denotes that CD40
T3608 6635-6669 Entity denotes ligands that may be involved in RA
T3607 4527-4548 Entity denotes anti-CD154 antibodies
T3606 4235-4240 Protein denotes CD154
T3605 3622-3624 Protein denotes RA
T3604 3693-3697 Protein denotes RANK
T3603 3990-4004 Entity denotes of cell types,
T3602 3417-3430 Protein denotes for severe RA
T3601 6067-6136 Entity denotes of the most putative endogenous TLR4 ligands involved in RA pathology
T3600 3105-3110 Protein denotes NF-κB
T3599 6138-6143 Protein denotes HMGB1
T3598 5154-5180 Protein denotes Toll-like receptors (TLRs)
T3597 5927-5932 Protein denotes HMGB1
T3596 4177-4205 Protein denotes cytokines including TNF [10]
T3595 4197-4205 Protein denotes TNF [10]
T3594 5280-5295 Protein denotes NF-κB-dependent
T3593 5371-5432 Entity denotes of endogenous ligands - a group of proteins derived from host
T3592 6248-6253 Protein denotes HMGB1
T3591 3903-3907 Protein denotes CD40
T3590 3782-3810 Protein denotes proper RANK-NF-κB signalling
T3589 5145-5152 Protein denotes RA [13]
T3588 6759-6767 Protein denotes tenascin
T3587 6862-6910 Entity denotes several TLR ligands in the inflamed joint tissue
T3586 5880-5934 Protein denotes High mobility group box chromosomal protein 1 (HMGB1),
T3585 6405-6414 Entity denotes molecules
T3584 3661-3682 Protein denotes by receptor activator
T3687 6565-6577 Protein denotes TLR4-induced
T3686 3375-3378 Protein denotes TNF
T3685 4222-4226 Protein denotes CD40
T3684 5011-5044 Protein denotes lymphotoxin β receptor signalling
T3683 4942-4961 Entity denotes antagonists of BAFF
T3682 3840-3852 Protein denotes RA pathology
T3681 3253-3255 Protein denotes RA
T3680 4527-4548 Protein denotes anti-CD154 antibodies
T3679 6664-6669 Protein denotes in RA
T3678 3782-3810 Protein denotes proper RANK-NF-κB signalling
T3677 6602-6604 Protein denotes RA
T3676 4289-4314 Entity denotes of activated CD4+ T cells
T3675 3467-3503 Entity denotes both very potent activators of NF-κB
T3674 4092-4099 Entity denotes B cells
T3673 4325-4330 Protein denotes NF-κB
T3672 4783-4809 Protein denotes TNF receptor family member
T3671 4413-4422 Protein denotes cytokines
T3670 4934-4937 Entity denotes RA,
T3669 3324-3328 Protein denotes IL-1
T3668 3532-3567 Protein denotes NF-κB activation by these cytokines
T3667 3644-3649 Protein denotes NF-κB
T3666 4892-4905 Entity denotes B lymphocytes
T1590 3006-3044 Positive_regulation denotes of NF-κB activation in RA pathogenesis
T1589 2116-2218 Positive_regulation denotes NF-κB activation can be detected in cultured synovial fibroblasts and synovial tissue from RA patients
T1588 1229-1270 Binding denotes infiltrating monocytes and synovial cells
T1587 1505-1539 Regulation denotes of NF-κB-dependent gene expression
T1586 2859-2899 Binding denotes a genetic association with several genes
T1585 1618-1623 Protein denotes NF-κB
T1584 1746-1757 Protein denotes RelA, RelB,
T1583 1746-1763 Protein denotes RelA, RelB, c-Rel
T1582 2207-2209 Protein denotes RA
T1581 1200-1225 Protein denotes matrix metalloproteinases
T1580 2785-2819 Protein denotes osteolytic diseases such as RA [7]
T1579 1508-1523 Protein denotes NF-κB-dependent
T1578 2676-2681 Protein denotes NF-κB
T1577 1120-1144 Entity denotes proinflammatory T-helper
T1576 1932-1964 Protein denotes inducible nitric oxide synthase,
T1575 3029-3044 Protein denotes RA pathogenesis
T1574 1242-1251 Entity denotes monocytes
T1573 2676-2696 Entity denotes NF-κB ligand (RANKL)
T1572 2341-2346 Protein denotes of RA
T1571 1868-1883 Protein denotes genes - such as
T1570 1018-1026 Entity denotes of cells
T1569 1889-1893 Protein denotes IL-1
T1568 1715-1721 Protein denotes NF-κB2
T1567 2035-2038 Protein denotes TNF
T1566 3009-3014 Protein denotes NF-κB
T1565 2690-2695 Protein denotes RANKL
T1564 2063-2094 Entity denotes very potent activators of NF-κB
T1563 1707-1711 Protein denotes p100
T1562 1752-1756 Protein denotes RelB
T1561 2015-2020 Protein denotes in RA
T1560 2953-2960 Protein denotes TNFAIP3
T1559 1731-1737 Protein denotes NF-κB1
T1558 2043-2047 Protein denotes IL-1
T1557 2116-2121 Protein denotes NF-κB
T1556 1170-1182 Protein denotes 17 cytokines
T1555 1782-1792 Entity denotes homodimers
T1554 2571-2576 Protein denotes NF-κB
T1553 1884-1894 Protein denotes TNF, IL-1,
T1552 2297-2305 Protein denotes of NF-κB
T1551 1286-1309 Entity denotes of synovial fibroblasts
T1550 2456-2464 Protein denotes of NF-κB
T1549 1184-1195 Protein denotes chemokines,
T1548 1865-1975 Protein denotes of genes - such as TNF, IL-1, IL-6, cyclo-oxygenase-2, chemokines, inducible nitric oxide synthase, and matrix
T1547 2966-2971 Protein denotes c-REL
T1546 1579-1581 Protein denotes RA
T1545 709-711 Protein denotes RA
T1544 1145-1151 Protein denotes type 1
T1543 2940-2944 Protein denotes CD40
T1542 1901-1918 Protein denotes cyclo-oxygenase-2
T1541 1723-1727 Protein denotes p105
T1540 1156-1164 Entity denotes T-helper
T1539 1697-1764 Protein denotes proteins (p100 or NF-κB2, p105 or NF-κB1, p65 or RelA, RelB, c-Rel)
T1538 2881-2899 Protein denotes with several genes
T1537 1256-1270 Entity denotes synovial cells
T1536 2912-2929 Protein denotes NF-κB signalling,
T1535 2152-2181 Entity denotes cultured synovial fibroblasts
T1534 2654-2696 Protein denotes receptor activator of NF-κB ligand (RANKL)
T1533 2946-2951 Protein denotes TRAF1
T1532 1434-1439 Protein denotes of RA
T1531 1796-1808 Entity denotes heterodimers
T1530 2089-2094 Protein denotes NF-κB
T1529 1895-1919 Protein denotes IL-6, cyclo-oxygenase-2,
T1528 1707-1742 Protein denotes p100 or NF-κB2, p105 or NF-κB1, p65
T239 572-585 Regulation denotes control NF-κB
T238 193-237 Binding denotes inappropriate NF-κB activity has been linked
T237 207-212 Protein denotes NF-κB
T235 369-385 Protein denotes NF-κB signalling
T234 108-113 Protein denotes NF-κB
T233 318-323 Entity denotes Cells
T232 580-585 Protein denotes NF-κB
T231 475-480 Protein denotes NF-κB
R201 T232 T239 themeOf NF-κB,control NF-κB
R1258 T1538 T1586 themeOf with several genes,a genetic association with several genes
R1263 T1557 T1589 themeOf NF-κB,NF-κB activation can be detected in cultured synovial fibroblasts and synovial tissue from RA patients
R1264 T1566 T1590 themeOf NF-κB,of NF-κB activation in RA pathogenesis
R1265 T1579 T1587 causeOf NF-κB-dependent,of NF-κB-dependent gene expression
R2747 T3584 T3693 causeOf by receptor activator,"NF-κB activation by receptor activator of NF-κB (RANK), a TNF receptor family member,"
R2750 T3598 T3692 themeOf Toll-like receptors (TLRs),Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases
R2768 T3602 T3694 themeOf for severe RA,an effective treatment for severe RA
R2772 T3645 T3698 themeOf NF-κB,NF-κB activation
R2773 T3646 T3696 themeOf proteins derived from host,proteins derived from host
R2774 T3667 T3693 themeOf NF-κB,"NF-κB activation by receptor activator of NF-κB (RANK), a TNF receptor family member,"
R2775 T3673 T3695 themeOf NF-κB,NF-κB activation resulting
R5467 T7978 T8195 causeOf of a distinct E2/E3 enzyme complex that modifies NEMO with linear polyubiquitin chains and is essential for TNF-activated NF-κB signalling,of a distinct E2/E3 enzyme complex that modifies NEMO with linear polyubiquitin chains and is essential for TNF-activated NF-κB signalling
R5468 T7979 T8198 causeOf CD40-mediated,CD40-mediated JNK activation
R5471 T7983 T8179 themeOf cIAP2,which in turn bind the E3 ubiquitin ligases cellular inhibitor of apoptosis (cIAP) 1 and cIAP2
R5472 T7986 T8176 causeOf IκBξ,IκBξ and Bcl-3 instead potentiate NF-κB transactivation in the nucleus
R5473 T7987 T8177 themeOf JNK,CD40-mediated JNK activation
R5474 T7988 T8171 themeOf TNF-receptor bound RIP1,TNF-receptor bound RIP1
R5475 T7989 T8168 themeOf of Toll/IL-1 receptor adaptor protein,the recruitment of Toll/IL-1 receptor adaptor protein
R5479 T7991 T8192 themeOf TIR domain-containing adaptor-inducing IFNβ (TRIF),"to recruit myeloid differentiation primary response gene 88 (MyD88) and TIR domain-containing adaptor-inducing IFNβ (TRIF), respectively"
R5487 T8011 T8181 themeOf IL-6,"IL-6 production,"
R5489 T8013 T8193 themeOf IKK1,IKK1 phosphorylation
R5491 T8015 T8178 themeOf the E3 ubiquitin ligases cellular inhibitor of apoptosis (cIAP) 1,which in turn bind the E3 ubiquitin ligases cellular inhibitor of apoptosis (cIAP) 1 and cIAP2
R5493 T8018 T8197 themeOf of NF-κB,"activation of NF-κB,"
R5495 T8019 T8189 themeOf of TRAF6 [24],ubiquitination of TRAF6 [24]
R5497 T8023 T8184 themeOf TRAF2,"to attract TRAF2 and cIAP1/2,"
R5500 T8027 T8173 themeOf TRAF3,"to remove TRAF3 from this complex by recruiting it to the receptor,"
R5501 T8028 T8184 themeOf "cIAP1/2,","to attract TRAF2 and cIAP1/2,"
R5502 T8029 T8172 themeOf NIK,to releasing NIK
R5505 T8037 T8185 themeOf B cells TRAF6,B cells TRAF6
R5506 T8038 T8206 themeOf TLR4,TLR4 stimulation by lipopolysaccharide
R5508 T8039 T8201 causeOf lymphotoxin β receptor,lymphotoxin β receptor and RANK mediate the activation of both canonical and noncanonical NF-κB signalling pathways
R5511 T8042 T8199 themeOf for TNF-activated NF-κB signalling,for TNF-activated NF-κB signalling
R5514 T8045 T8191 themeOf NF-κB,NF-κB transactivation in the nucleus
R5522 T8057 T8196 themeOf associated with overlapping and distinct CD40-mediated,associated with overlapping and distinct CD40-mediated
R5527 T8064 T8182 themeOf RIP1,also recruits TRAF6 [25] and RIP1 [26] via a direct interaction
R5530 T8067 T8185 locationOf B cells,B cells TRAF6
R5532 T8069 T8203 themeOf TRAF3,for subsequent TRAF3 degradation
R5539 T8087 T8187 themeOf RIP1,"RIP1 ubiquitination,"
R5544 T8092 T8206 causeOf by lipopolysaccharide,TLR4 stimulation by lipopolysaccharide
R5545 T8098 T8180 themeOf NF-κB,canonical NF-κB activation [21]
R5549 T8106 T8200 causeOf RANK,lymphotoxin β receptor and RANK mediate the activation of both canonical and noncanonical NF-κB signalling pathways
R5550 T8109 T8186 themeOf TNF,TNF stimulation
R5551 T8203 T8188 themeOf for subsequent TRAF3 degradation,which are essential for subsequent TRAF3 degradation
R5552 T8117 T8182 themeOf TRAF6 [25],also recruits TRAF6 [25] and RIP1 [26] via a direct interaction
R5553 T8123 T8174 themeOf NF-κB proteins,NF-κB proteins are sequestered in the cytoplasm as latent complexes by inhibitory proteins
R5554 T8124 T8169 themeOf of TNF receptor-1-associated death domain (TRADD) protein,in the recruitment of TNF receptor-1-associated death domain (TRADD) protein
R5555 T8130 T8183 themeOf TNF,TNF stimulation
R5556 T8139 T8199 causeOf TNF-activated,for TNF-activated NF-κB signalling
R5557 T8141 T8192 themeOf myeloid differentiation primary response gene 88 (MyD88),"to recruit myeloid differentiation primary response gene 88 (MyD88) and TIR domain-containing adaptor-inducing IFNβ (TRIF), respectively"
R5558 T8142 T8195 themeOf NEMO,of a distinct E2/E3 enzyme complex that modifies NEMO with linear polyubiquitin chains and is essential for TNF-activated NF-κB signalling
R5559 T8145 T8194 themeOf the IKK and TAK1 complex,to recruit the IKK and TAK1 complex via the ubiquitin-binding proteins NEMO and TAB1/2
R5560 T8150 T8175 causeOf Bcl-3,IκBξ and Bcl-3 instead potentiate NF-κB transactivation in the nucleus
R5561 T8151 T8202 themeOf NIK,NIK accumulation
R5562 T8155 T8171 themeOf TNF-receptor bound,TNF-receptor bound RIP1
R5563 T8159 T8170 themeOf binding proteins,binding proteins
R5564 T8177 T8198 themeOf CD40-mediated JNK activation,CD40-mediated JNK activation
R5565 T8191 T8175 themeOf NF-κB transactivation in the nucleus,IκBξ and Bcl-3 instead potentiate NF-κB transactivation in the nucleus
R5566 T8191 T8176 themeOf NF-κB transactivation in the nucleus,IκBξ and Bcl-3 instead potentiate NF-κB transactivation in the nucleus
R6314 T9292 T9334 themeOf nuclear NF-κB,inhibit nuclear NF-κB
R6315 T9300 T9339 themeOf of the noncanonical NF-κB,regulation of the noncanonical NF-κB
R6316 T9303 T9331 themeOf of NF-κB,the control of NF-κB
R6317 T9305 T9335 themeOf IKK2,enhanced IKK2 activation
R6318 T9306 T9336 themeOf NF-κB,NF-κB activation
R6319 T9307 T9332 themeOf NF-κB,persistent NF-κB activation
R6320 T9308 T9330 themeOf NIK,"Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback"
R6321 T9311 T9337 themeOf IκBα,IκBα degradation
R6322 T9313 T9330 causeOf IKK1,"Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback"
R6323 T9316 T9338 themeOf STAT1 [35],phosphorylating STAT1 [35]
R6324 T9319 T9333 themeOf inactive IKK1,expressing inactive IKK1
R6325 T9332 T9327 themeOf persistent NF-κB activation,prevent persistent NF-κB activation
R6326 T9335 T9329 themeOf enhanced IKK2 activation,enhanced IKK2 activation
R8261 T12283 T12406 themeOf A20,could show repressed A20 transcription
R8270 T12286 T12407 locationOf B cells,"that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells"
R8271 T12289 T12414 themeOf A20,A20 expression
R8273 T12314 T12407 locationOf T cells,"that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells"
R8274 T12316 T12410 themeOf A20,A20 expression
R8275 T12325 T12407 locationOf specific cell types such as synovial fibroblasts,"that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells"
R8276 T12326 T12409 themeOf ubiquitin,specific ubiquitin-binding
R8277 T12330 T12407 themeOf "that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells","that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells"
R8278 T12335 T12404 themeOf NF-κB,NF-κB activation
R8279 T12342 T12407 locationOf macrophages,"that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells"
R8280 T12346 T12405 themeOf of A20,The association of A20
R8281 T12352 T12413 themeOf A20,"by NF-κB [50], implicating A20"
R8282 T12358 T12419 causeOf NF-κB-dependent,NF-κB-dependent gene expression
R8283 T12366 T12418 themeOf a major antiapoptotic protein in the intestinal epithelium [47],a major antiapoptotic protein in the intestinal epithelium [47]
R8284 T12387 T12407 locationOf dendritic cells,"that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells"
R8285 T12401 T12415 themeOf A20,A20 overexpression
R8286 T12401 T12416 themeOf A20,A20 overexpression
R8287 T12402 T12385 partOf A20 promoter,A20
R8288 T12404 T12408 themeOf NF-κB activation,"suppressing NF-κB activation,"
R8289 T12405 T12417 themeOf The association of A20,The association of A20 with its targets requires specific ubiquitin-binding
R8290 T12406 T12411 themeOf could show repressed A20 transcription,repressed A20 transcription
R8291 T12409 T12417 causeOf specific ubiquitin-binding,The association of A20 with its targets requires specific ubiquitin-binding
R9283 T13898 T13952 causeOf TNF-induced,"TNF-induced genes in human synoviocytes,"
R9284 T13902 T13957 themeOf Functional ABIN-3,Functional ABIN-3 is expressed in humans
R9285 T13904 T13956 themeOf autoantibody,autoantibody production
R9286 T13911 T13954 locationOf "human synoviocytes,","TNF-induced genes in human synoviocytes,"
R9287 T13923 T13959 themeOf A20 interacting proteins,A20 interacting proteins
R9288 T13924 T13958 themeOf NF-κB,of NF-κB activation
R9289 T13932 T13952 themeOf "TNF-induced genes in human synoviocytes,","TNF-induced genes in human synoviocytes,"
R9290 T13932 T13953 themeOf "TNF-induced genes in human synoviocytes,","TNF-induced genes in human synoviocytes,"
R9291 T13932 T13954 themeOf "TNF-induced genes in human synoviocytes,","TNF-induced genes in human synoviocytes,"
R9292 T13936 T13955 themeOf of the NF-κB inhibitory proteins ABIN-3 and A20,on the expression of the NF-κB inhibitory proteins ABIN-3 and A20
R9293 T13942 T13951 themeOf A20 interacting proteins,ubiquitously expressed A20 interacting proteins and were shown to inhibit NF-κB activation by TNF and several
R10144 T15304 T15358 themeOf NF-κB,"that negatively regulates NF-κB signalling initiated by TNFR, RANK and T-cell receptor stimulation"
R10145 T15304 T15366 themeOf NF-κB,NF-κB signalling initiated
R10146 T15307 T15363 themeOf T-cell receptor,T-cell receptor stimulation
R10147 T15307 T15364 themeOf T-cell receptor,T-cell receptor
R10148 T15312 T15362 causeOf CYLD-mediated,by the CYLD-mediated deubiquitination of TRAF6
R10149 T15314 T15361 themeOf CYLD,CYLD expression
R10150 T15329 T15360 causeOf A20 as well as CYLD,A20 as well as CYLD to control NF-κB activation
R10151 T15330 T15367 themeOf ubiquitinated TRAF6,ubiquitinated TRAF6
R10152 T15339 T15364 locationOf T-cell,T-cell receptor
R10153 T15343 T15365 causeOf CYLD,"Interestingly, CYLD has been shown to negatively regulate RANK signalling and osteoclastogenesis in mice [65]"
R10154 T15345 T15365 themeOf RANK signalling and osteoclastogenesis in mice [65],"Interestingly, CYLD has been shown to negatively regulate RANK signalling and osteoclastogenesis in mice [65]"
R10155 T15349 T15359 themeOf NF-κB,NF-κB activation
R10156 T15359 T15360 themeOf NF-κB activation,A20 as well as CYLD to control NF-κB activation
R10735 T16202 T16240 themeOf MyD88,"direct interaction with these receptors, MyD88, IRAK1 or TRAF6 [67] (Figure 1)"
R10736 T16211 T16240 themeOf TRAF6 [67],"direct interaction with these receptors, MyD88, IRAK1 or TRAF6 [67] (Figure 1)"
R10737 T16212 T16242 causeOf by human RA synovial cells,the spontaneous release of inflammatory cytokines by human RA synovial cells
R10738 T16217 T16242 themeOf of inflammatory cytokines,the spontaneous release of inflammatory cytokines by human RA synovial cells
R10739 T16230 T16241 themeOf of SIGIRR,to compare the expression of SIGIRR in RA patients with its expression in control
R10740 T16233 T16240 themeOf IRAK1,"direct interaction with these receptors, MyD88, IRAK1 or TRAF6 [67] (Figure 1)"
R10741 T16236 T16245 themeOf SIGIRR,SIGIRR overexpression
R10742 T16236 T16246 themeOf SIGIRR,SIGIRR overexpression
R10743 T16237 T16240 themeOf these receptors,"direct interaction with these receptors, MyD88, IRAK1 or TRAF6 [67] (Figure 1)"
R10744 T16242 T16243 themeOf the spontaneous release of inflammatory cytokines by human RA synovial cells,"Recently, SIGIRR overexpression was shown to inhibit the spontaneous release of inflammatory cytokines by human RA synovial cells"
R10745 T16242 T16244 themeOf the spontaneous release of inflammatory cytokines by human RA synovial cells,"Recently, SIGIRR overexpression was shown to inhibit the spontaneous release of inflammatory cytokines by human RA synovial cells"
R10746 T16245 T16244 causeOf SIGIRR overexpression,"Recently, SIGIRR overexpression was shown to inhibit the spontaneous release of inflammatory cytokines by human RA synovial cells"
R10747 T16246 T16243 causeOf SIGIRR overexpression,"Recently, SIGIRR overexpression was shown to inhibit the spontaneous release of inflammatory cytokines by human RA synovial cells"
R11362 T17222 T17264 themeOf other signalling proteins,binding to the receptor or other signalling proteins
R11363 T17223 T17259 themeOf of TRAF1,Expression of TRAF1
R11364 T17233 T17264 themeOf the receptor,binding to the receptor or other signalling proteins
R11365 T17235 T17261 themeOf NF-κB,TNF-induced NF-κB activation
R11366 T17244 T17258 causeOf TRAF1,by TNF and overexpression of TRAF1 inhibits TNF-induced NF-κB activation
R11367 T17248 T17263 themeOf NF-κB,CD40-induced NF-κB activation
R11368 T17257 T17260 themeOf A20,recruit A20
R11369 T17261 T17258 themeOf TNF-induced NF-κB activation,by TNF and overexpression of TRAF1 inhibits TNF-induced NF-κB activation
R12451 T18786 T18853 themeOf protein,of protein expression
R12452 T18811 T18866 themeOf mRNA,of target mRNA degradation
R12453 T18817 T18858 themeOf matrix metalloproteinase-1,to increased secretion of matrix metalloproteinase-1 and IL-6
R12454 T18833 T18867 themeOf miR-155,"Notably, both miR-146 and miR-155 are expressed at higher levels in RA synovial fibroblasts"
R12455 T18835 T18860 themeOf miR-155,miR-155 overexpression in synovial fibroblasts
R12456 T18835 T18861 themeOf miR-155,miR-155 overexpression in synovial fibroblasts
R12457 T18839 T18864 causeOf of specific matrix metalloproteinases that mediate tissue destruction in RA [81],of specific matrix metalloproteinases that mediate tissue destruction in RA [81]
R12458 T18839 T18865 themeOf of specific matrix metalloproteinases that mediate tissue destruction in RA [81],cytokine-inducible expression of specific matrix metalloproteinases that mediate tissue destruction in RA [81]
R12459 T18845 T18862 themeOf miR-146a,"miR-146a is also overexpressed in CD4+ and IL-17-producing T cells from RA patients [84,85]"
R12460 T18845 T18863 themeOf miR-146a,"miR-146a is also overexpressed in CD4+ and IL-17-producing T cells from RA patients [84,85]"
R12461 T18850 T18859 themeOf IL-6,to increased secretion of matrix metalloproteinase-1 and IL-6
R12462 T18858 T18854 themeOf to increased secretion of matrix metalloproteinase-1 and IL-6,to increased secretion of matrix metalloproteinase-1 and IL-6
R12463 T18859 T18855 themeOf to increased secretion of matrix metalloproteinase-1 and IL-6,to increased secretion of matrix metalloproteinase-1 and IL-6
R12464 T18866 T18856 themeOf of target mRNA degradation,the promotion of target mRNA degradation [77]
R12748 T19198 T19203 themeOf NF-κB,NF-κB activation
R13883 T21072 T21183 themeOf TRAFs,"K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1,"
R13884 T21076 T21186 themeOf TRAF6,binding to IRAK1 and TRAF6
R13885 T21077 T21173 themeOf membrane receptors,membrane receptors
R13886 T21084 T21190 causeOf TAK1,"TAK1 then phosphorylates and activates IKK2,"
R13887 T21088 T21181 themeOf RIP1,"K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1,"
R13888 T21089 T21192 causeOf NF-κB dependent,The expression of many of these negative regulatory molecules is NF-κB dependent
R13889 T21104 T21179 themeOf NF-κB activation,that control NF-κB activation by targeting specific signalling proteins including RIP1 and TRAF6
R13890 T21106 T21180 themeOf NF-κB,"NF-κB activation,"
R13891 T21110 T21187 themeOf "IκBα,","which in turn phosphorylates IκBα,"
R13892 T21118 T21173 locationOf membrane,membrane receptors
R13893 T21121 T21185 themeOf adaptor proteins,specific ubiquitin-binding adaptor proteins such
R13894 T21141 T21182 themeOf IRAK1,"K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1,"
R13895 T21152 T21184 themeOf NF-κB,of NF-κB activation
R13896 T21153 T21188 themeOf IRAK1,expression of IRAK1 and TRAF6
R13897 T21154 T21186 themeOf IRAK1,binding to IRAK1 and TRAF6
R13898 T21155 T21191 themeOf "inhibited by the transmembrane protein SIGIRR,","inhibited by the transmembrane protein SIGIRR,"
R13899 T21162 T21191 causeOf by the transmembrane protein,"inhibited by the transmembrane protein SIGIRR,"
R13900 T21163 T21185 themeOf specific ubiquitin-binding adaptor proteins such,specific ubiquitin-binding adaptor proteins such
R13901 T21164 T21190 themeOf "IKK2,","TAK1 then phosphorylates and activates IKK2,"
R13902 T21167 T21189 themeOf TRAF6,expression of IRAK1 and TRAF6
R13903 T21180 T21177 themeOf "NF-κB activation,","can negatively regulate NF-κB activation, most probably by competing with other TRAFs"
R13904 T21188 T21174 themeOf expression of IRAK1 and TRAF6,inhibiting expression of IRAK1 and TRAF6
R13905 T21189 T21175 themeOf expression of IRAK1 and TRAF6,inhibiting expression of IRAK1 and TRAF6
R14595 T22423 T22484 themeOf NF-κB p100,NF-κB p100 phosphorylation
R14596 T22426 T22483 themeOf "of NIK, keeping NIK levels low","proteasomal degradation of NIK, keeping NIK levels low"
R14597 T22429 T22475 themeOf NIK,NIK is stabilised
R14598 T22438 T22479 causeOf TRAF2,"where TRAF2 directs nondegradative K63-linked polyubiquitination of cIAP1/2, resulting in their activation"
R14599 T22444 T22474 themeOf TNF receptor-associated factor; TNF,TNF receptor-associated factor; TNF
R14600 T22445 T22480 themeOf of p100,"partial proteasomal degradation of p100 to p52,"
R14601 T22447 T22474 themeOf TNF receptor-associated,TNF receptor-associated factor; TNF
R14602 T22449 T22478 themeOf "IKK1,","NIK then phosphorylates and activates IKK1,"
R14603 T22462 T22478 causeOf NIK,"NIK then phosphorylates and activates IKK1,"
R14604 T22463 T22477 causeOf cIAP1/2,"Subsequently cIAP1/2 directs its K48-linked polyubiquitination to TRAF3, rather than NIK"
R14605 T22465 T22481 themeOf K48-linked,its K48-linked polyubiquitination
R14606 T22466 T22486 themeOf TRAF3,TRAF3 is degraded
R14607 T22467 T22485 themeOf NF-κB inducing kinase (NIK),on NF-κB inducing kinase (NIK) expression
R14608 T22484 T22476 themeOf NF-κB p100 phosphorylation,which mediates NF-κB p100 phosphorylation

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T22308 15143-15165 Protein denotes tumour necrosis factor
T22307 15138-15141 Protein denotes TNF
T22306 15106-15136 Protein denotes TNF receptor-associated factor
T22305 15100-15104 Protein denotes TRAF
T22304 15093-15098 Protein denotes NF-κB
T22303 15065-15069 Protein denotes RANK
T22302 15045-15063 Protein denotes NF, nuclear factor
T22301 15033-15043 Protein denotes IκB kinase
T22300 15028-15031 Protein denotes IKK
T22299 14935-14944 Binding denotes competing
T22277 14555-14558 Protein denotes NIK
T22276 14513-14516 Protein denotes NIK
T22275 14491-14496 Protein denotes TRAF3
T22274 14473-14476 Protein denotes NIK
T22273 14454-14459 Protein denotes TRAF3
T22272 14253-14262 Binding denotes recruited
T22271 14235-14242 Binding denotes binding
T22270 14348-14355 Protein denotes cIAP1/2
T22269 14286-14291 Protein denotes TRAF2
T22268 14244-14249 Protein denotes TRAF3
T22267 14179-14190 Protein_catabolism denotes degradation
T22266 14207-14210 Protein denotes NIK
T20894 10701-10723 Protein denotes tumour necrosis factor
T20893 10696-10699 Protein denotes TNF
T20892 10676-10694 Protein denotes Toll-like receptor
T20891 10671-10674 Protein denotes TLR
T20890 10639-10669 Protein denotes TNF receptor-associated factor
T20889 10633-10637 Protein denotes TRAF
T20888 10626-10631 Protein denotes IL-1R
T20887 10607-10625 Protein denotes Toll-like receptor
T20886 10602-10605 Protein denotes TIR
T20885 10558-10592 Protein denotes single-immunoglobulinIL-1 receptor
T20884 10550-10556 Protein denotes SIGIRR
T20883 10518-10548 Protein denotes receptor interacting protein 1
T20882 10512-10516 Protein denotes RIP1
T20881 10505-10510 Protein denotes NF-κB
T20880 10477-10481 Protein denotes RANK
T20879 10430-10435 Protein denotes NF-κB
T20878 10424-10428 Protein denotes NEMO
T20877 10367-10372 Protein denotes MyD88
T20876 10342-10347 Protein denotes IL-1R
T20875 10336-10340 Protein denotes IRAK
T20874 10329-10334 Protein denotes NF-κB
T20873 10311-10314 Protein denotes IκB
T20872 10299-10309 Protein denotes IκB kinase
T20871 10294-10297 Protein denotes IKK
T20870 10232-10236 Protein denotes cIAP
T20869 10225-10230 Protein denotes NF-κB
T20868 10176-10181 Protein denotes NF-κB
T20867 10103-10108 Protein denotes NF-κB
T20866 10010-10017 Binding denotes binding
T20865 10010-10017 Binding denotes binding
T20864 9988-9995 Binding denotes compete
T20863 9914-9923 Negative_regulation denotes inhibited
T20862 10031-10036 Protein denotes TRAF6
T20861 10021-10026 Protein denotes IRAK1
T20860 10001-10005 Protein denotes TLR4
T20859 9887-9890 Protein denotes TLR
T20858 9809-9817 Regulation denotes regulate
T20857 9809-9817 Regulation denotes regulate
T20856 9836-9846 Negative_regulation denotes inhibiting
T20855 9836-9846 Negative_regulation denotes inhibiting
T20854 9847-9857 Gene_expression denotes expression
T20853 9847-9857 Gene_expression denotes expression
T20852 9871-9876 Protein denotes TRAF6
T20851 9861-9866 Protein denotes IRAK1
T20850 9818-9821 Protein denotes TLR
T20849 9581-9588 Regulation denotes control
T20848 9581-9588 Regulation denotes control
T20847 9595-9605 Positive_regulation denotes activation
T20846 9771-9774 Protein denotes p62
T20845 9667-9672 Protein denotes TRAF6
T20844 9658-9662 Protein denotes RIP1
T20843 9589-9594 Protein denotes NF-κB
T20842 9542-9546 Protein denotes CYLD
T20841 9534-9537 Protein denotes A20
T20840 9462-9470 Regulation denotes regulate
T20839 9506-9515 Binding denotes competing
T20838 9477-9487 Positive_regulation denotes activation
T20837 9527-9532 Protein denotes TRAFs
T20836 9471-9476 Protein denotes NF-κB
T20835 9420-9436 Protein denotes ubiquitin ligase
T20834 9400-9405 Protein denotes TRAF1
T20833 9337-9348 Localization denotes translocate
T20832 9356-9363 Entity denotes nucleus
T20831 9329-9332 Protein denotes p50
T20830 9321-9324 Protein denotes p65
T20829 9283-9288 Protein denotes NF-κB
T20828 9201-9211 Positive_regulation denotes triggering
T20827 9258-9269 Protein_catabolism denotes degradation
T20826 9180-9194 Phosphorylation denotes phosphorylates
T20825 9180-9194 Phosphorylation denotes phosphorylates
T20824 9150-9159 Positive_regulation denotes activates
T20823 9131-9145 Phosphorylation denotes phosphorylates
T20822 9195-9199 Protein denotes IκBα
T20821 9160-9164 Protein denotes IKK2
T20820 9121-9125 Protein denotes TAK1
T20819 9063-9074 Binding denotes recruitment
T20818 8961-8979 Localization denotes polyubiquitination
T20817 8961-8979 Localization denotes polyubiquitination
T20816 9115-9119 Protein denotes TAK1
T20815 9106-9110 Protein denotes IKK2
T20814 9032-9044 Protein denotes TAB proteins
T20813 9023-9027 Protein denotes NEMO
T20812 8999-9004 Protein denotes IRAK1
T20811 8990-8994 Protein denotes RIP1
T20810 8983-8988 Protein denotes TRAFs
T20809 8926-8931 Protein denotes cIAP2
T20808 8919-8924 Protein denotes cIAP1
T20807 8912-8917 Protein denotes TRAF6
T20806 8905-8910 Protein denotes TRAF2
T20805 8886-8903 Protein denotes ubiquitin ligases
T20804 8874-8879 Protein denotes IRAK4
T20803 8867-8872 Protein denotes IRAK1
T19049 33514-33519 Protein denotes NF-κB
T19048 33134-33144 Regulation denotes regulation
T19047 33152-33157 Protein denotes NF-κB
T19046 32978-32988 Positive_regulation denotes activation
T19045 32972-32977 Protein denotes NF-κB
T19044 32827-32839 Protein denotes NF-κB family
T18634 32521-32530 Positive_regulation denotes increased
T18633 32521-32530 Positive_regulation denotes increased
T18632 32510-32517 Positive_regulation denotes leading
T18631 32510-32517 Positive_regulation denotes leading
T18630 32531-32540 Localization denotes secretion
T18629 32531-32540 Localization denotes secretion
T18628 32575-32579 Protein denotes IL-6
T18627 32544-32570 Protein denotes matrix metalloproteinase-1
T18626 32421-32430 Negative_regulation denotes decreased
T18625 32358-32402 Protein denotes chemokine monocyte chemoattractant protein 1
T18624 32324-32332 Protein denotes miR-124a
T18623 32226-32231 Protein denotes NF-κB
T18622 31672-31679 Positive_regulation denotes promote
T18621 31684-31694 Gene_expression denotes production
T18620 31680-31683 Protein denotes TNF
T18619 31509-31516 Negative_regulation denotes prevent
T18618 31548-31558 Gene_expression denotes expression
T18617 31578-31596 Protein denotes metalloproteinases
T18616 31364-31372 Protein denotes miR-146a
T18615 31263-31278 Gene_expression denotes IL-17-producing
T18614 31237-31250 Positive_regulation denotes overexpressed
T18613 31254-31258 Protein denotes CD4+
T18612 31220-31228 Protein denotes miR-146a
T18611 31067-31076 Gene_expression denotes expressed
T18610 31067-31076 Gene_expression denotes expressed
T18609 31055-31062 Protein denotes miR-155
T18608 31043-31050 Protein denotes miR-146
T18607 31020-31026 Entity denotes [79,80
T18606 30996-31019 Protein denotes molecules IKKε and RIP1
T17119 29059-29073 Positive_regulation denotes overexpression
T17118 29059-29073 Gene_expression denotes overexpression
T17117 29038-29047 Positive_regulation denotes inducible
T17116 29015-29025 Gene_expression denotes Expression
T17115 29104-29109 Protein denotes NF-κB
T17114 29092-29095 Protein denotes TNF
T17113 29077-29082 Protein denotes TRAF1
T17112 29051-29054 Protein denotes TNF
T17111 29029-29034 Protein denotes TRAF1
T17110 28943-28963 Protein denotes TNF family receptors
T17109 28915-28920 Protein denotes NF-κB
T17108 28862-28867 Protein denotes TRAF1
T17107 28792-28797 Negative_regulation denotes lacks
T17106 28798-28814 Protein denotes ubiquitin ligase
T17105 28720-28724 Protein denotes TRAF
T17104 28688-28693 Protein denotes TRAF1
T17103 28655-28685 Protein denotes TNF receptor-associated factor
T15812 28574-28584 Gene_expression denotes expression
T15811 28594-28600 Protein denotes SIGIRR
T15810 28510-28516 Protein denotes SIGIRR
T15809 28307-28315 Protein denotes collagen
T15808 28168-28174 Protein denotes SIGIRR
T15807 28026-28040 Positive_regulation denotes overexpression
T15806 28026-28040 Gene_expression denotes overexpression
T15805 28019-28025 Protein denotes SIGIRR
T15804 27709-27713 Positive_regulation denotes role
T15803 27709-27713 Positive_regulation denotes role
T15802 27813-27819 Protein denotes SIGIRR
T15801 27727-27730 Protein denotes TLR
T15800 27717-27722 Protein denotes IL-1R
T15799 27553-27562 Negative_regulation denotes inhibitor
T15798 27553-27562 Negative_regulation denotes inhibitor
T15797 27616-27627 Binding denotes interaction
T15796 27616-27627 Binding denotes interaction
T15795 27666-27671 Protein denotes TRAF6
T15794 27657-27662 Protein denotes IRAK1
T15793 27650-27655 Protein denotes MyD88
T15792 27576-27579 Protein denotes TLR
T15791 27566-27571 Protein denotes IL-1R
T15790 27490-27506 Protein denotes TLR/IL-1R family
T15789 27464-27469 Protein denotes TIR-8
T15788 27388-27423 Protein denotes Single-immunoglobulin IL-1 receptor
T15787 27336-27371 Protein denotes Single-immunoglobulin IL-1 receptor
T15167 27244-27248 Protein denotes CYLD
T15166 27148-27153 Protein denotes NF-κB
T15165 27135-27139 Protein denotes RANK
T15164 26964-26974 Gene_expression denotes expressing
T15163 26993-26996 Protein denotes p62
T15162 26730-26739 Negative_regulation denotes recruited
T15161 26658-26669 Positive_regulation denotes upregulated
T15160 26635-26645 Gene_expression denotes expression
T15159 26896-26901 Protein denotes TRAF6
T15158 26805-26808 Protein denotes p62
T15157 26771-26780 Protein denotes ubiquitin
T15156 26743-26762 Protein denotes ubiquitinated TRAF6
T15155 26690-26695 Protein denotes RANKL
T15154 26630-26634 Protein denotes CYLD
T15153 26559-26564 Protein denotes RANKL
T15152 26406-26416 Negative_regulation denotes deficiency
T15151 26420-26424 Protein denotes CYLD
T15150 26324-26332 Regulation denotes regulate
T15149 26333-26337 Protein denotes RANK
T15148 26290-26294 Protein denotes CYLD
T15147 26091-26100 Regulation denotes regulates
T15146 26117-26122 Protein denotes NF-κB
T15145 25956-25963 Regulation denotes control
T15144 25970-25980 Positive_regulation denotes activation
T15143 25964-25969 Protein denotes NF-κB
T15142 25948-25952 Protein denotes CYLD
T15141 25628-25637 Regulation denotes regulates
T15140 25628-25637 Regulation denotes regulates
T15139 25628-25637 Regulation denotes regulates
T15138 25628-25637 Regulation denotes regulates
T15137 25628-25637 Regulation denotes regulates
T15136 25628-25637 Regulation denotes regulates
T15135 25628-25637 Regulation denotes regulates
T15134 25745-25762 Gene_expression denotes deubiquitina-ting
T15133 25745-25762 Gene_expression denotes deubiquitina-ting
T15132 25745-25762 Gene_expression denotes deubiquitina-ting
T15131 25745-25762 Gene_expression denotes deubiquitina-ting
T15130 25745-25762 Gene_expression denotes deubiquitina-ting
T15129 25745-25762 Gene_expression denotes deubiquitina-ting
T15128 25745-25762 Gene_expression denotes deubiquitina-ting
T15127 25843-25847 Protein denotes TAK1
T15126 25834-25838 Protein denotes RIP1
T15125 25827-25832 Protein denotes TRAF7
T15124 25820-25825 Protein denotes TRAF6
T15123 25813-25818 Protein denotes TRAF2
T15122 25807-25811 Protein denotes NEMO
T15121 25771-25796 Protein denotes NF-κB signalling proteins
T15120 25683-25698 Protein denotes T-cell receptor
T15119 25674-25678 Protein denotes RANK
T15118 25668-25672 Protein denotes TNFR
T15117 25638-25643 Protein denotes NF-κB
T15116 25578-25582 Protein denotes CYLD
T15115 25385-25389 Protein denotes CYLD
T13777 23387-23391 Protein denotes ABIN
T13776 23383-23386 Protein denotes A20
T13775 23329-23334 Protein denotes NF-κB
T13774 23152-23157 Protein denotes ABINs
T13773 23052-23059 Negative_regulation denotes inhibit
T13772 23066-23076 Positive_regulation denotes activation
T13771 22999-23008 Gene_expression denotes expressed
T13770 23080-23083 Protein denotes TNF
T13769 23060-23065 Protein denotes NF-κB
T13768 23009-23033 Protein denotes A20 interacting proteins
T13767 22959-22965 Protein denotes TNIP-3
T13766 22947-22953 Protein denotes TNIP-2
T13765 22939-22945 Protein denotes TNIP-1
T13764 22878-22888 Negative_regulation denotes inhibitors
T13763 22892-22897 Protein denotes NF-κB
T13802 24600-24610 Negative_regulation denotes suppressed
T13801 24582-24586 Protein denotes ITAM
T13800 24468-24474 Regulation denotes depend
T13799 24468-24474 Regulation denotes depend
T13798 24468-24474 Regulation denotes depend
T13797 24482-24492 Gene_expression denotes expression
T13796 24482-24492 Gene_expression denotes expression
T13795 24482-24492 Gene_expression denotes expression
T13794 24352-24362 Negative_regulation denotes inhibition
T13793 24537-24540 Protein denotes A20
T13792 24517-24532 Protein denotes proteins ABIN-3
T13791 24500-24505 Protein denotes NF-κB
T13790 24366-24369 Protein denotes TLR
T13789 24126-24132 Positive_regulation denotes levels
T13788 24283-24288 Protein denotes NF-κB
T13787 24136-24147 Protein denotes ABIN-1 mRNA
T13786 24076-24079 Protein denotes TNF
T13785 23962-23965 Protein denotes TNF
T13784 23883-23886 Protein denotes TNF
T13783 23810-23819 Protein denotes ubiquitin
T13782 23641-23646 Protein denotes NF-κB
T13781 23580-23585 Protein denotes NF-κB
T13780 23370-23374 Positive_regulation denotes role
T13779 23370-23374 Positive_regulation denotes role
T13778 23439-23444 Protein denotes NF-κB
T12010 22791-22799 Protein denotes A20 SNPs
T12009 22507-22519 Protein denotes A20 promoter
T12008 22176-22179 Protein denotes TNF
T12007 22151-22154 Protein denotes TNF
T12006 22116-22119 Protein denotes A20
T12005 21828-21837 Protein denotes A20 locus
T12004 21601-21616 Protein denotes human A20 locus
T12003 21166-21180 Positive_regulation denotes overexpression
T12002 21166-21180 Gene_expression denotes overexpression
T12001 21162-21165 Protein denotes A20
T12000 20970-20979 Negative_regulation denotes decreased
T11999 20970-20979 Negative_regulation denotes decreased
T11998 21004-21009 Protein denotes IL-1β
T11997 20996-20999 Protein denotes TNF
T11996 20869-20874 Protein denotes IL-1β
T11995 20861-20864 Protein denotes TNF
T11994 20553-20563 Negative_regulation denotes inhibition
T11993 20553-20563 Negative_regulation denotes inhibition
T11992 20553-20563 Negative_regulation denotes inhibition
T11991 20553-20563 Negative_regulation denotes inhibition
T11990 20553-20563 Negative_regulation denotes inhibition
T11989 20586-20595 Negative_regulation denotes decreased
T11988 20586-20595 Negative_regulation denotes decreased
T11987 20586-20595 Negative_regulation denotes decreased
T11986 20586-20595 Negative_regulation denotes decreased
T11985 20586-20595 Negative_regulation denotes decreased
T11984 20503-20513 Gene_expression denotes expression
T11983 20814-20820 Protein denotes NF- κB
T11982 20793-20798 Protein denotes NF-κB
T11981 20738-20746 Protein denotes collagen
T11980 20680-20685 Protein denotes IL-17
T11979 20632-20637 Protein denotes RANKL
T11978 20618-20622 Protein denotes IL-6
T11977 20611-20616 Protein denotes IL-1β
T11976 20606-20609 Protein denotes TNF
T11975 20567-20572 Protein denotes NF-κB
T11974 20499-20502 Protein denotes A20
T11973 20275-20285 Gene_expression denotes expressing
T11972 20397-20405 Protein denotes collagen
T11971 20271-20274 Protein denotes A20
T11970 20131-20140 Regulation denotes regulated
T11969 20110-20120 Gene_expression denotes expression
T11968 20211-20216 Protein denotes NF-κB
T11967 20144-20149 Protein denotes NF-κB
T11966 20106-20109 Protein denotes A20
T11965 19933-19943 Gene_expression denotes expression
T11964 19929-19932 Protein denotes A20
T11963 19853-19858 Protein denotes NF-κB
T11962 19643-19646 Protein denotes TNF
T11961 19360-19363 Protein denotes TNF
T11960 18934-18945 Negative_regulation denotes suppressing
T11959 18952-18962 Positive_regulation denotes activation
T11958 18964-18967 Protein denotes A20
T11957 18946-18951 Protein denotes NF-κB
T11956 18850-18859 Negative_regulation denotes inhibitor
T11955 18850-18859 Negative_regulation denotes inhibitor
T11954 18738-18749 Binding denotes association
T11953 18882-18904 Protein denotes Tax1-binding protein 1
T11952 18863-18877 Protein denotes NF-κB (ABIN) 1
T11951 18753-18756 Protein denotes A20
T11950 18698-18710 Negative_regulation denotes downregulate
T11949 18711-18716 Protein denotes NF-κB
T11948 18628-18635 Protein denotes cIAP1/2
T11947 18618-18623 Protein denotes TRAF2
T11946 18611-18616 Protein denotes TRAF6
T11945 18589-18609 Protein denotes E3 ubiquitin ligases
T11944 18577-18583 Protein denotes Ubc5hc
T11943 18567-18572 Protein denotes Ubc13
T11942 18533-18545 Protein denotes E2 ubiquitin
T11941 18451-18463 Binding denotes interactions
T11940 18320-18336 Positive_regulation denotes deubiquitinating
T11939 18320-18336 Positive_regulation denotes deubiquitinating
T11938 18320-18336 Positive_regulation denotes deubiquitinating
T11937 18320-18336 Positive_regulation denotes deubiquitinating
T11936 18320-18336 Positive_regulation denotes deubiquitinating
T11935 18294-18301 Negative_regulation denotes inhibit
T11934 18404-18409 Protein denotes MALT1
T11933 18394-18399 Protein denotes TRAF6
T11932 18388-18392 Protein denotes RIP2
T11931 18382-18386 Protein denotes RIP1
T11930 18346-18351 Protein denotes NF-κB
T11929 18302-18307 Protein denotes NF-κB
T11928 18275-18278 Protein denotes A20
T11927 18137-18141 Protein denotes IL-1
T11926 18132-18135 Protein denotes TNF
T11925 18038-18043 Protein denotes NF-κB
T11924 17996-18003 Protein denotes editing
T11923 17986-17995 Protein denotes ubiquitin
T11922 17972-17979 Protein denotes TNFAIP3
T11921 17953-17956 Protein denotes A20
T11920 17941-17952 Protein denotes A20 protein
T9228 17665-17679 Phosphorylation denotes phosphorylates
T9227 17665-17679 Phosphorylation denotes phosphorylates
T9226 17855-17860 Protein denotes NF-κB
T9225 17781-17785 Protein denotes IKK1
T9224 17736-17741 Protein denotes NF-κB
T9223 17680-17683 Protein denotes NIK
T9222 17660-17664 Protein denotes IKK1
T9221 17508-17515 Negative_regulation denotes inhibit
T9220 17580-17595 Phosphorylation denotes phosphorylating
T9219 17596-17601 Protein denotes STAT1
T9218 17516-17529 Protein denotes nuclear NF-κB
T9217 17480-17484 Protein denotes IKK1
T9216 17302-17311 Negative_regulation denotes deficient
T9215 17428-17436 Positive_regulation denotes enhanced
T9214 17428-17436 Positive_regulation denotes enhanced
T9213 17333-17343 Gene_expression denotes expressing
T9212 17302-17311 Negative_regulation denotes deficient
T9211 17457-17478 Protein denotes IκBα degradation [34]
T9210 17437-17441 Protein denotes IKK2
T9209 17353-17357 Protein denotes IKK1
T9208 17297-17301 Protein denotes IKK1
T9207 17264-17269 Protein denotes NF-κB
T9206 17119-17124 Protein denotes NF-κB
T9205 17069-17073 Protein denotes IKK1
T9204 16903-16909 Protein denotes IRAK-M
T9203 16895-16901 Protein denotes MyD88s
T9202 16847-16852 Protein denotes NF-κB
T9201 16716-16720 Regulation denotes role
T9200 16730-16735 Protein denotes NF-κB
T9199 16620-16625 Protein denotes NF-κB
T9198 16570-16575 Protein denotes NF-κB
T9197 16427-16439 Negative_regulation denotes downregulate
T9196 16440-16445 Protein denotes NF-κB
T9195 16251-16261 Positive_regulation denotes activation
T9194 16245-16250 Protein denotes NF-κB
T9193 16195-16200 Protein denotes NF-κB
T9192 16035-16045 Regulation denotes regulation
T9191 15974-15984 Positive_regulation denotes activation
T9190 16053-16058 Protein denotes NF-κB
T9189 15968-15973 Protein denotes NF-κB
T7585 15812-15820 Positive_regulation denotes required
T7584 15765-15775 Positive_regulation denotes activation
T7583 15752-15760 Positive_regulation denotes mediated
T7582 15734-15742 Positive_regulation denotes required
T7581 15734-15742 Positive_regulation denotes required
T7580 15825-15835 Positive_regulation denotes activation
T7579 15785-15795 Gene_expression denotes production
T7578 15765-15775 Positive_regulation denotes activation
T7577 15890-15894 Protein denotes CD40
T7576 15850-15855 Protein denotes TRAF3
T7575 15839-15844 Protein denotes NF-κB
T7574 15803-15808 Protein denotes TRAF2
T7573 15780-15784 Protein denotes IL-6
T7572 15761-15764 Protein denotes JNK
T7571 15747-15751 Protein denotes CD40
T7570 15635-15645 Binding denotes associated
T7569 15676-15680 Protein denotes CD40
T7568 15616-15630 Protein denotes TRAF molecules
T7567 15456-15461 Positive_regulation denotes leads
T7566 15456-15461 Positive_regulation denotes leads
T7565 15469-15480 Protein_catabolism denotes proteolysis
T7564 15469-15480 Protein_catabolism denotes proteolysis
T7534 13803-13818 Phosphorylation denotes phosphorylation
T7533 13781-13793 Positive_regulation denotes accumulation
T7532 13798-13802 Protein denotes IKK1
T7531 13777-13780 Protein denotes NIK
T7530 13678-13689 Protein_catabolism denotes degradation
T7529 13678-13689 Protein_catabolism denotes degradation
T7528 13533-13539 Negative_regulation denotes remove
T7527 13628-13635 Protein denotes cIAP1/2
T7526 13618-13623 Protein denotes TRAF2
T7525 13540-13545 Protein denotes TRAF3
T7524 13431-13438 Positive_regulation denotes leading
T7523 13457-13468 Protein_catabolism denotes degradation
T7522 13358-13365 Binding denotes complex
T7521 13358-13365 Binding denotes complex
T7520 13358-13365 Binding denotes complex
T7519 13389-13396 Protein denotes cIAP1/2
T7518 13378-13383 Protein denotes TRAF3
T7517 13371-13376 Protein denotes TRAF2
T7516 13330-13333 Protein denotes NIK
T7515 13122-13131 Positive_regulation denotes activated
T7514 13122-13131 Positive_regulation denotes activated
T7513 13122-13131 Positive_regulation denotes activated
T7512 13122-13131 Positive_regulation denotes activated
T7511 13137-13152 Phosphorylation denotes phosphorylation
T7510 13137-13152 Phosphorylation denotes phosphorylation
T7509 13122-13131 Positive_regulation denotes activated
T7508 13094-13103 Positive_regulation denotes dependent
T7507 13179-13182 Protein denotes NIK
T7506 13156-13177 Protein denotes NF-κB inducing kinase
T7505 13107-13111 Protein denotes IKK1
T7504 13068-13073 Protein denotes NF-κB
T7503 12900-12902 Protein denotes κB
T7502 12892-12899 Protein denotes RelB NF
T7501 12863-12866 Protein denotes p52
T7500 12824-12828 Protein denotes p100
T7499 12790-12794 Protein denotes RANK
T7498 12780-12784 Protein denotes CD40
T7497 12765-12778 Protein denotes BAFF receptor
T7496 12741-12763 Protein denotes lymphotoxin β receptor
T7495 12703-12708 Protein denotes NF-κB
T7494 12588-12596 Positive_regulation denotes activate
T7493 12588-12596 Positive_regulation denotes activate
T7492 12662-12665 Protein denotes TNF
T7491 12606-12609 Protein denotes IKK
T7490 12597-12601 Protein denotes TAK1
T7489 12509-12517 Negative_regulation denotes recruits
T7488 12509-12517 Negative_regulation denotes recruits
T7487 12533-12537 Protein denotes RIP1
T7486 12518-12523 Protein denotes TRAF6
T7485 12499-12503 Protein denotes TRIF
T7484 12445-12460 Binding denotes oligomerisation
T7483 12361-12369 Binding denotes recruits
T7482 12361-12369 Binding denotes recruits
T7481 12487-12492 Protein denotes TRAF6
T7480 12427-12432 Protein denotes TRAF6
T7479 12410-12414 Protein denotes IRAK
T7478 12385-12408 Protein denotes IL-1R-associated kinase
T7477 12347-12352 Protein denotes MyD88
T7476 12033-12040 Positive_regulation denotes induces
T7475 12212-12219 Binding denotes recruit
T7474 12212-12219 Binding denotes recruit
T7473 12212-12219 Binding denotes recruit
T7472 12212-12219 Binding denotes recruit
T7471 12212-12219 Binding denotes recruit
T7470 12045-12056 Binding denotes recruitment
T7469 11999-12010 Positive_regulation denotes stimulation
T7468 12220-12268 Protein denotes myeloid differentiation primary response gene 88
T7467 12326-12330 Protein denotes TRIF
T7466 12320-12324 Protein denotes IFNβ
T7465 12281-12284 Protein denotes TIR
T7464 12270-12275 Protein denotes MyD88
T7463 12125-12129 Protein denotes TRIF
T7462 12116-12119 Protein denotes Mal
T7461 12060-12094 Protein denotes Toll/IL-1 receptor adaptor protein
T7460 11994-11998 Protein denotes TLR4
T7459 11893-11901 Positive_regulation denotes activate
T7458 11906-11910 Protein denotes TAK1
T7457 11859-11872 Protein denotes polyubiquitin
T7456 11776-11789 Protein denotes polyubiquitin
T7455 11684-11693 Positive_regulation denotes activated
T7454 11694-11699 Protein denotes NF-κB
T7453 11680-11683 Protein denotes TNF
T7452 11589-11591 Protein denotes E3
T7451 11586-11588 Protein denotes E2
T7450 11524-11530 Protein denotes TAB1/2
T7449 11515-11519 Protein denotes NEMO
T7448 11488-11497 Protein denotes ubiquitin
T7447 11467-11471 Protein denotes TAK1
T7446 11459-11462 Protein denotes IKK
T7445 11405-11409 Protein denotes RIP1
T7444 11381-11394 Protein denotes polyubiquitin
T7443 11308-11312 Protein denotes RIP1
T7442 11276-11283 Protein denotes cIAP1/2
T7441 11264-11271 Protein denotes TRAF2/5
T7440 11171-11182 Positive_regulation denotes stimulation
T7439 11242-11255 Protein denotes polyubiquitin
T7438 11203-11207 Protein denotes RIP1
T7437 11184-11196 Protein denotes TNF-receptor
T7436 11167-11170 Protein denotes TNF
T7435 11019-11029 Binding denotes associated
T7434 11019-11029 Binding denotes associated
T7433 10826-10837 Binding denotes recruitment
T7432 10826-10837 Binding denotes recruitment
T7431 10826-10837 Binding denotes recruitment
T7430 10826-10837 Binding denotes recruitment
T7429 10826-10837 Binding denotes recruitment
T7428 10826-10837 Binding denotes recruitment
T7427 11083-11100 Protein denotes ubiquitin ligases
T7426 11080-11082 Protein denotes E3
T7425 11050-11055 Protein denotes TRAF5
T7424 11006-11018 Protein denotes TNF receptor
T7423 10985-10997 Protein denotes E3 ubiquitin
T7422 10935-10939 Protein denotes RIP1
T7421 10903-10933 Protein denotes receptor interacting protein 1
T7420 10881-10886 Protein denotes TRADD
T7419 10841-10879 Protein denotes TNF receptor-1-associated death domain
T7418 10795-10798 Protein denotes TNF
T7417 10782-10785 Protein denotes TNF
T7416 10749-10754 Protein denotes NF-κB
T7415 8484-8492 Positive_regulation denotes required
T7414 8484-8492 Positive_regulation denotes required
T7413 8484-8492 Positive_regulation denotes required
T7412 8513-8523 Positive_regulation denotes activation
T7411 8507-8512 Protein denotes NF-κB
T7410 8474-8478 Protein denotes IKK1
T7409 8460-8464 Protein denotes NEMO
T7408 8451-8455 Protein denotes IKK2
T7407 8235-8244 Gene_expression denotes comprised
T7406 8235-8244 Gene_expression denotes comprised
T7405 8235-8244 Gene_expression denotes comprised
T7404 8338-8351 Protein denotes subunit NF-κB
T7403 8313-8317 Protein denotes IKKβ
T7402 8304-8308 Protein denotes IKKα
T7401 8284-8288 Protein denotes IKK2
T7400 8275-8279 Protein denotes IKK1
T7399 8220-8231 Protein denotes IKK complex
T7398 8083-8091 Positive_regulation denotes mediates
T7397 8083-8091 Positive_regulation denotes mediates
T7396 8083-8091 Positive_regulation denotes mediates
T7395 8033-8043 Positive_regulation denotes activation
T7394 8033-8043 Positive_regulation denotes activation
T7393 8180-8191 Protein_catabolism denotes degradation
T7392 8180-8191 Protein_catabolism denotes degradation
T7391 8092-8107 Phosphorylation denotes phosphorylation
T7390 8068-8075 Entity denotes complex
T7389 8126-8137 Protein denotes IκB protein
T7388 8063-8066 Protein denotes IKK
T7387 8051-8061 Protein denotes IκB kinase
T7386 7854-7859 Protein denotes NF-κB
T7385 7841-7844 Protein denotes TLR
T7384 7830-7835 Protein denotes RANKL
T7383 7808-7811 Protein denotes TNF
T7382 7659-7664 Protein denotes NF-κB
T7381 7632-7634 Protein denotes κB
T7380 7536-7541 Protein denotes NF-κB
T7379 7481-7499 Protein denotes p50 NF-κB subunits
T7378 7473-7476 Protein denotes p52
T7377 7446-7450 Protein denotes p105
T7376 7437-7441 Protein denotes p100
T7375 7344-7354 Negative_regulation denotes inhibitors
T7374 7344-7354 Negative_regulation denotes inhibitors
T7373 7405-7420 Positive_regulation denotes transactivation
T7372 7405-7420 Positive_regulation denotes transactivation
T7371 7344-7354 Negative_regulation denotes inhibitors
T7370 7388-7404 Protein denotes potentiate NF-κB
T7369 7374-7379 Protein denotes Bcl-3
T7368 7365-7369 Protein denotes IκBξ
T7563 15362-15370 Binding denotes interact
T7562 15362-15370 Binding denotes interact
T7561 15323-15330 Binding denotes binding
T7560 15323-15330 Binding denotes binding
T7559 15323-15330 Binding denotes binding
T7558 15323-15330 Binding denotes binding
T7557 15323-15330 Binding denotes binding
T7556 15323-15330 Binding denotes binding
T7555 15323-15330 Binding denotes binding
T7554 15323-15330 Binding denotes binding
T7553 15323-15330 Binding denotes binding
T7552 15323-15330 Binding denotes binding
T7551 15323-15330 Binding denotes binding
T7550 15499-15504 Protein denotes TRAF3
T7549 15489-15494 Protein denotes TRAF2
T7548 15440-15445 Protein denotes TRAF6
T7547 15429-15434 Protein denotes TRAF5
T7546 15422-15427 Protein denotes TRAF3
T7545 15415-15420 Protein denotes TRAF2
T7544 15408-15413 Protein denotes TRAF1
T7543 15357-15361 Protein denotes RANK
T7542 15348-15352 Protein denotes CD40
T7541 15291-15296 Protein denotes NF-κB
T7540 15228-15232 Protein denotes RANK
T7539 15201-15223 Protein denotes lymphotoxin β receptor
T7538 15195-15199 Protein denotes CD40
T7537 13781-13793 Positive_regulation denotes accumulation
T7536 13764-13773 Positive_regulation denotes resulting
T7535 13764-13773 Positive_regulation denotes resulting
T3444 4765-4775 Gene_expression denotes expression
T3443 4836-4840 Protein denotes BAFF
T3442 4783-4834 Protein denotes TNF receptor family member B-cell activating factor
T3441 4576-4588 Protein denotes CD40 signals
T3440 4527-4548 Protein denotes anti-CD154 antibodies
T3439 4519-4523 Protein denotes CD40
T3438 4331-4341 Positive_regulation denotes activation
T3437 4331-4341 Positive_regulation denotes activation
T3436 4264-4273 Gene_expression denotes expressed
T3435 4264-4273 Gene_expression denotes expressed
T3359 4207-4214 Binding denotes Binding
T3358 4328-4330 Protein denotes κB
T3357 4325-4327 Protein denotes NF
T3356 4302-4306 Protein denotes CD4+
T3355 4235-4240 Protein denotes CD154
T3354 4222-4233 Protein denotes CD40 ligand
T3353 4146-4157 Positive_regulation denotes upregulated
T3352 4146-4157 Positive_regulation denotes upregulated
T3351 4146-4157 Positive_regulation denotes upregulated
T3350 3967-3976 Gene_expression denotes expressed
T3349 3967-3976 Gene_expression denotes expressed
T3348 3919-3945 Protein denotes TNF receptor family member
T3347 3903-3907 Protein denotes CD40
T1341 1823-1831 Regulation denotes regulate
T1340 1823-1831 Regulation denotes regulate
T1313 1901-1918 Protein denotes cyclo-oxygenase-2
T1312 1895-1899 Protein denotes IL-6
T1311 1889-1893 Protein denotes IL-1
T1310 1884-1887 Protein denotes TNF
T1309 1758-1763 Protein denotes c-Rel
T1308 1752-1756 Protein denotes RelB
T1307 1746-1750 Protein denotes RelA
T1306 1739-1742 Protein denotes p65
T1305 1731-1737 Protein denotes NF-κB1
T1304 1723-1727 Protein denotes p105
T1303 1715-1721 Protein denotes NF-κB2
T1302 1707-1711 Protein denotes p100
T213 9-19 Regulation denotes regulation
T214 37-48 Regulation denotes involvement
T1301 1618-1623 Protein denotes NF-κB
T1300 1508-1513 Protein denotes NF-κB
T215 87-113 Protein denotes transcription factor NF-κB
T216 207-212 Protein denotes NF-κB
T217 369-374 Protein denotes NF-κB
T218 475-480 Protein denotes NF-κB
T219 580-585 Protein denotes NF-κB
T220 572-579 Regulation denotes control
T211 23-28 Protein denotes NF-κB
T212 0-8 Gene_expression denotes Negative
T1339 1823-1831 Regulation denotes regulate
T1338 1823-1831 Regulation denotes regulate
T1337 1823-1831 Regulation denotes regulate
T1336 1823-1831 Regulation denotes regulate
T1335 1823-1831 Regulation denotes regulate
T1334 1823-1831 Regulation denotes regulate
T1333 1823-1831 Regulation denotes regulate
T1332 1823-1831 Regulation denotes regulate
T1331 1823-1831 Regulation denotes regulate
T1330 1823-1831 Regulation denotes regulate
T1329 1823-1831 Regulation denotes regulate
T1328 1823-1831 Regulation denotes regulate
T1327 1823-1831 Regulation denotes regulate
T1326 1823-1831 Regulation denotes regulate
T1325 1823-1831 Regulation denotes regulate
T1324 1823-1831 Regulation denotes regulate
T1323 1823-1831 Regulation denotes regulate
T1322 1932-1941 Positive_regulation denotes inducible
T1321 1836-1846 Gene_expression denotes expression
T1320 1836-1846 Gene_expression denotes expression
T1319 1836-1846 Gene_expression denotes expression
T1318 1836-1846 Gene_expression denotes expression
T1317 1836-1846 Gene_expression denotes expression
T1316 1836-1846 Gene_expression denotes expression
T1315 1976-1994 Protein denotes metalloproteinases
T1314 1942-1963 Protein denotes nitric oxide synthase
T1349 1823-1831 Regulation denotes regulate
T1348 1823-1831 Regulation denotes regulate
T1347 1823-1831 Regulation denotes regulate
T1346 1823-1831 Regulation denotes regulate
T1345 1823-1831 Regulation denotes regulate
T1344 1823-1831 Regulation denotes regulate
T1343 1823-1831 Regulation denotes regulate
T1342 1823-1831 Regulation denotes regulate
T1365 2300-2305 Protein denotes NF-κB
T1364 2116-2121 Protein denotes NF-κB
T1363 2075-2085 Positive_regulation denotes activators
T1362 2075-2085 Positive_regulation denotes activators
T1361 2089-2094 Protein denotes NF-κB
T1360 2043-2047 Protein denotes IL-1
T1359 2035-2038 Protein denotes TNF
T1358 1823-1831 Regulation denotes regulate
T1357 1823-1831 Regulation denotes regulate
T1356 1823-1831 Regulation denotes regulate
T1355 1823-1831 Regulation denotes regulate
T1354 1823-1831 Regulation denotes regulate
T1353 1823-1831 Regulation denotes regulate
T1352 1823-1831 Regulation denotes regulate
T1351 1823-1831 Regulation denotes regulate
T1350 1823-1831 Regulation denotes regulate
T1367 2385-2390 Protein denotes NF-κB
T1366 2122-2132 Positive_regulation denotes activation
T3343 3702-3728 Protein denotes TNF receptor family member
T3342 3693-3697 Protein denotes RANK
T3341 3686-3691 Protein denotes NF-κB
T3340 3644-3649 Protein denotes NF-κB
T3339 3568-3576 Positive_regulation denotes mediates
T3338 3538-3548 Positive_regulation denotes activation
T3337 3532-3537 Protein denotes NF-κB
T3336 3498-3503 Protein denotes NF-κB
T3335 3458-3462 Protein denotes IL-1
T3334 3450-3453 Protein denotes TNF
T3333 3375-3378 Protein denotes TNF
T3332 3324-3328 Protein denotes IL-1
T3331 3316-3319 Protein denotes TNF
T3330 3235-3243 Positive_regulation denotes activate
T3329 3244-3249 Protein denotes NF-κB
T3328 3105-3110 Protein denotes NF-κB
T3346 3650-3660 Positive_regulation denotes activation
T3345 3650-3660 Positive_regulation denotes activation
T3344 3789-3799 Protein denotes RANK-NF-κB
T1381 3015-3025 Positive_regulation denotes activation
T1380 3009-3014 Protein denotes NF-κB
T1379 2953-2960 Protein denotes TNFAIP3
T1378 2946-2951 Protein denotes TRAF1
T1377 2940-2944 Protein denotes CD40
T1376 2912-2917 Protein denotes NF-κB
T1375 2663-2672 Positive_regulation denotes activator
T1374 2663-2672 Positive_regulation denotes activator
T1373 2690-2695 Protein denotes RANKL
T1372 2676-2688 Protein denotes NF-κB ligand
T1371 2571-2576 Protein denotes NF-κB
T1370 2447-2455 Negative_regulation denotes blockade
T1369 2391-2401 Positive_regulation denotes activation
T1368 2459-2464 Protein denotes NF-κB
T3434 4207-4214 Binding denotes Binding
T18605 30979-30984 Protein denotes NF-κB
T18604 30894-30902 Protein denotes miR-146a
T18603 30853-30858 Protein denotes TRAF6
T18602 30843-30848 Protein denotes IRAK1
T18601 30816-30821 Protein denotes NF-κB
T18600 30786-30791 Protein denotes NF-κB
T18599 30771-30779 Protein denotes miR-146a
T18598 30736-30739 Protein denotes TNF
T18597 30729-30734 Protein denotes IL-1β
T18596 30656-30661 Protein denotes NF-κB
T18595 30590-30597 Protein denotes miR-155
T18594 30575-30585 Protein denotes miR-146a/b
T3472 6915-6925 Positive_regulation denotes contribute
T3471 6935-6945 Positive_regulation denotes activation
T3470 6929-6934 Protein denotes NF-κB
T3469 6759-6769 Protein denotes tenascin C
T3468 6736-6747 Protein denotes fibronectin
T3467 6724-6734 Protein denotes fibrinogen
T3466 6565-6569 Protein denotes TLR4
T3465 6432-6443 Protein denotes S100 family
T3464 6147-6156 Positive_regulation denotes increased
T3463 6270-6278 Protein denotes collagen
T3462 6248-6253 Protein denotes HMGB1
T3461 6233-6244 Protein denotes BoxA domain
T3460 6183-6212 Protein denotes HMGB1 neutralising antibodies
T3459 6138-6143 Protein denotes HMGB1
T3458 6032-6040 Localization denotes released
T3457 6032-6040 Localization denotes released
T3456 5995-6003 Localization denotes secreted
T3455 5995-6003 Localization denotes secreted
T3454 6099-6103 Protein denotes TLR4
T3453 5927-5932 Protein denotes HMGB1
T3452 5880-5925 Protein denotes High mobility group box chromosomal protein 1
T3451 5760-5765 Negative_regulation denotes block
T3450 5766-5769 Protein denotes TLR
T3449 5280-5285 Protein denotes NF-κB
T3448 5011-5033 Protein denotes lymphotoxin β receptor
T3447 4756-4764 Positive_regulation denotes Enhanced
T3446 4756-4764 Positive_regulation denotes Enhanced
T3445 4765-4775 Gene_expression denotes expression
T7367 7358-7363 Protein denotes NF-κB
T7366 7326-7332 Protein denotes NF-κB2
T7365 7306-7310 Protein denotes p100
T7364 7297-7303 Protein denotes NF-κB1
T7363 7277-7281 Protein denotes p105
T7362 7171-7178 Negative_regulation denotes prevent
T7361 7171-7178 Negative_regulation denotes prevent
T7360 7193-7206 Localization denotes translocation
T7359 7185-7192 Entity denotes nuclear
T7358 7130-7139 Negative_regulation denotes inhibitor
T7357 7130-7139 Negative_regulation denotes inhibitor
T7356 7179-7184 Protein denotes NF-κB
T7355 7150-7153 Protein denotes IκB
T7354 7143-7148 Protein denotes NF-κB
T7353 7024-7038 Protein denotes NF-κB proteins
T22265 14194-14197 Protein denotes NIK
T22264 14102-14109 Protein denotes cIAP1/2
T22263 14092-14097 Protein denotes TRAF3
T22262 14085-14090 Protein denotes TRAF2
T22261 14067-14076 Protein denotes ubiquitin
T22260 13946-13955 Positive_regulation denotes dependent
T22259 13946-13955 Positive_regulation denotes dependent
T22258 13987-13997 Gene_expression denotes expression
T22257 13987-13997 Gene_expression denotes expression
T22256 13982-13985 Protein denotes NIK
T22255 13959-13980 Protein denotes NF-κB inducing kinase
T22254 13924-13929 Protein denotes NF-κB
T22253 13889-13893 Protein denotes RANK
T22252 13880-13884 Protein denotes CD40
T22251 13862-13867 Protein denotes NF-κB
T17143 30171-30182 Binding denotes association
T17142 30190-30195 Protein denotes TRAF1
T17141 30057-30062 Protein denotes TRAF1
T17140 29955-29989 Protein denotes TRAF1-complement component 5 locus
T17139 29761-29769 Binding denotes interact
T17138 29708-29713 Protein denotes TRAF1
T17137 29639-29646 Binding denotes binding
T17136 29639-29646 Binding denotes binding
T17135 29615-29619 Protein denotes TRAF
T17134 29595-29600 Protein denotes TRAF1
T17133 29534-29543 Regulation denotes modulates
T17132 29551-29561 Positive_regulation denotes activation
T17131 29544-29550 Protein denotes NF- κB
T17130 29528-29533 Protein denotes TRAF1
T17129 29336-29345 Negative_regulation denotes deficient
T17128 29426-29431 Protein denotes TRAF2
T17127 29330-29335 Protein denotes TRAF1
T17126 29312-29317 Protein denotes NF-κB
T17125 29299-29303 Protein denotes CD40
T17124 29251-29256 Protein denotes TRAF1
T17123 29128-29137 Negative_regulation denotes deficient
T17122 29225-29230 Protein denotes NF-κB
T17121 29170-29173 Protein denotes TNF
T17120 29122-29127 Protein denotes TRAF1
T22286 14649-14664 Phosphorylation denotes phosphorylation
T22285 14607-14616 Positive_regulation denotes activates
T22284 14588-14602 Phosphorylation denotes phosphorylates
T22283 14644-14648 Protein denotes p100
T22282 14638-14643 Protein denotes NF-κB
T22281 14617-14621 Protein denotes IKK1
T22280 14579-14582 Protein denotes NIK
T22279 14545-14554 Positive_regulation denotes increased
T22278 14500-14508 Protein_catabolism denotes degraded
T22298 14956-14987 Protein denotes TNF receptor-associated factors
T22297 14846-14851 Protein denotes TRAF1
T22296 14839-14844 Protein denotes TRAF3
T22295 14782-14793 Binding denotes heterodimer
T22294 14740-14751 Protein_catabolism denotes degradation
T22293 14740-14751 Protein_catabolism denotes degradation
T22292 14799-14803 Protein denotes RelB
T22291 14763-14766 Protein denotes p52
T22290 14755-14759 Protein denotes p100
T22289 14629-14637 Positive_regulation denotes mediates
T22288 14629-14637 Positive_regulation denotes mediates
T22287 14649-14664 Phosphorylation denotes phosphorylation
T20802 8861-8865 Protein denotes RIP1
T20801 8844-8848 Protein denotes TRIF
T20800 8838-8842 Protein denotes IFNβ
T20799 8799-8802 Protein denotes TIR
T20798 8794-8797 Protein denotes MAL
T20797 8787-8792 Protein denotes MyD88
T20796 8779-8784 Protein denotes TRADD
T20795 8731-8777 Protein denotes TNF receptor 1-associated death domain protein
T20794 8672-8676 Protein denotes TLR4
T20793 8662-8666 Protein denotes RANK
T20792 8656-8660 Protein denotes CD40
T20791 8649-8654 Protein denotes TNFR1
T20790 8550-8555 Protein denotes NF-κB
R202 T211 T212 themeOf NF-κB,Negative
R203 T212 T213 themeOf Negative,regulation
R204 T213 T214 themeOf regulation,involvement
R205 T219 T220 themeOf NF-κB,control
R1057 T1310 T1316 themeOf TNF,expression
R1060 T1311 T1317 themeOf IL-1,expression
R1061 T1312 T1318 themeOf IL-6,expression
R1062 T1313 T1319 themeOf cyclo-oxygenase-2,expression
R1063 T1314 T1320 themeOf nitric oxide synthase,expression
R1065 T1314 T1322 themeOf nitric oxide synthase,inducible
R1066 T1315 T1321 themeOf metalloproteinases,expression
R1067 T1316 T1323 themeOf expression,regulate
R1068 T1316 T1329 themeOf expression,regulate
R1069 T1316 T1335 themeOf expression,regulate
R1070 T1316 T1341 themeOf expression,regulate
R1071 T1316 T1347 themeOf expression,regulate
R1072 T1342 T1304 Cause regulate,p105
R1073 T1316 T1353 themeOf expression,regulate
R1074 T1317 T1324 themeOf expression,regulate
R1075 T1343 T1304 Cause regulate,p105
R1076 T1344 T1304 Cause regulate,p105
R1077 T1345 T1304 Cause regulate,p105
R1078 T1346 T1304 Cause regulate,p105
R1079 T1347 T1305 Cause regulate,NF-κB1
R1080 T1348 T1305 Cause regulate,NF-κB1
R1081 T1349 T1305 Cause regulate,NF-κB1
R1082 T1317 T1330 themeOf expression,regulate
R1083 T1350 T1305 Cause regulate,NF-κB1
R1084 T1351 T1305 Cause regulate,NF-κB1
R1085 T1352 T1305 Cause regulate,NF-κB1
R1086 T1353 T1307 Cause regulate,RelA
R1087 T1354 T1307 Cause regulate,RelA
R1088 T1355 T1307 Cause regulate,RelA
R1089 T1356 T1307 Cause regulate,RelA
R1090 T1357 T1307 Cause regulate,RelA
R1091 T1358 T1307 Cause regulate,RelA
R1092 T1361 T1362 themeOf NF-κB,activators
R1093 T1361 T1363 themeOf NF-κB,activators
R1094 T1362 T1359 Cause activators,TNF
R1095 T1363 T1360 Cause activators,IL-1
R1096 T1364 T1366 themeOf NF-κB,activation
R1097 T1367 T1369 themeOf NF-κB,activation
R1098 T1317 T1336 themeOf expression,regulate
R1099 T1368 T1370 themeOf NF-κB,blockade
R1100 T1317 T1342 themeOf expression,regulate
R1101 T1317 T1348 themeOf expression,regulate
R1102 T1317 T1354 themeOf expression,regulate
R1103 T1318 T1325 themeOf expression,regulate
R1104 T1372 T1374 themeOf NF-κB ligand,activator
R1105 T1373 T1375 themeOf RANKL,activator
R1106 T1380 T1381 themeOf NF-κB,activation
R1107 T1318 T1331 themeOf expression,regulate
R1108 T1318 T1337 themeOf expression,regulate
R1109 T1318 T1343 themeOf expression,regulate
R1110 T1318 T1349 themeOf expression,regulate
R1111 T1318 T1355 themeOf expression,regulate
R1112 T1319 T1326 themeOf expression,regulate
R1127 T1319 T1332 themeOf expression,regulate
R1128 T1319 T1338 themeOf expression,regulate
R1129 T1319 T1344 themeOf expression,regulate
R1130 T1319 T1350 themeOf expression,regulate
R1131 T1319 T1356 themeOf expression,regulate
R1132 T1320 T1327 themeOf expression,regulate
R1133 T1320 T1333 themeOf expression,regulate
R1134 T1320 T1339 themeOf expression,regulate
R1135 T1320 T1345 themeOf expression,regulate
R1136 T1320 T1351 themeOf expression,regulate
R1137 T1320 T1357 themeOf expression,regulate
R1138 T1321 T1328 themeOf expression,regulate
R1139 T1321 T1334 themeOf expression,regulate
R1140 T1321 T1340 themeOf expression,regulate
R1141 T1321 T1346 themeOf expression,regulate
R1142 T1321 T1352 themeOf expression,regulate
R1143 T1321 T1358 themeOf expression,regulate
R1144 T1323 T1301 Cause regulate,NF-κB
R1145 T1324 T1301 Cause regulate,NF-κB
R1146 T1325 T1301 Cause regulate,NF-κB
R1147 T1326 T1301 Cause regulate,NF-κB
R1149 T1327 T1301 Cause regulate,NF-κB
R1150 T1328 T1301 Cause regulate,NF-κB
R1151 T1329 T1302 Cause regulate,p100
R1152 T1330 T1302 Cause regulate,p100
R1153 T1331 T1302 Cause regulate,p100
R1154 T1332 T1302 Cause regulate,p100
R1155 T1333 T1302 Cause regulate,p100
R1156 T1334 T1302 Cause regulate,p100
R1157 T1335 T1303 Cause regulate,NF-κB2
R1158 T1336 T1303 Cause regulate,NF-κB2
R1159 T1337 T1303 Cause regulate,NF-κB2
R1160 T1338 T1303 Cause regulate,NF-κB2
R1162 T1339 T1303 Cause regulate,NF-κB2
R1166 T1340 T1303 Cause regulate,NF-κB2
R1171 T1341 T1304 Cause regulate,p105
R2648 T3329 T3330 themeOf NF-κB,activate
R2652 T3337 T3338 themeOf NF-κB,activation
R2654 T3338 T3339 themeOf activation,mediates
R2656 T3340 T3345 themeOf NF-κB,activation
R2658 T3343 T3346 themeOf TNF receptor family member,activation
R2662 T3347 T3349 themeOf CD40,expressed
R2663 T3347 T3351 themeOf CD40,upregulated
R2664 T3348 T3350 themeOf TNF receptor family member,expressed
R2666 T3349 T3352 themeOf expressed,upregulated
R2667 T3350 T3353 themeOf expressed,upregulated
R2670 T3354 T3359 themeOf CD40 ligand,Binding
R2671 T3354 T3435 themeOf CD40 ligand,expressed
R2672 T3355 T3434 themeOf CD154,Binding
R2673 T3355 T3436 themeOf CD154,expressed
R2675 T3357 T3437 themeOf NF,activation
R2676 T3358 T3438 themeOf κB,activation
R2707 T3445 T3447 themeOf expression,Enhanced
R2708 T3450 T3451 themeOf TLR,block
R2709 T3442 T3444 themeOf TNF receptor family member B-cell activating factor,expression
R2710 T3443 T3445 themeOf BAFF,expression
R2711 T3444 T3446 themeOf expression,Enhanced
R2712 T3452 T3455 themeOf High mobility group box chromosomal protein 1,secreted
R2713 T3452 T3457 themeOf High mobility group box chromosomal protein 1,released
R2714 T3453 T3456 themeOf HMGB1,secreted
R2715 T3453 T3458 themeOf HMGB1,released
R2716 T3459 T3464 themeOf HMGB1,increased
R2718 T3470 T3471 themeOf NF-κB,activation
R2726 T3471 T3472 themeOf activation,contribute
R5116 T7354 T7357 themeOf NF-κB,inhibitor
R5117 T7355 T7358 themeOf IκB,inhibitor
R5119 T7356 T7360 themeOf NF-κB,translocation
R5120 T7360 T7359 ToLoc translocation,nuclear
R5122 T7360 T7361 themeOf translocation,prevent
R5123 T7360 T7362 themeOf translocation,prevent
R5124 T7361 T7357 Cause prevent,inhibitor
R5125 T7362 T7358 Cause prevent,inhibitor
R5128 T7367 T7371 themeOf NF-κB,inhibitors
R5130 T7370 T7372 themeOf potentiate NF-κB,transactivation
R5131 T7370 T7373 themeOf potentiate NF-κB,transactivation
R5132 T7372 T7368 Cause transactivation,IκBξ
R5134 T7372 T7374 themeOf transactivation,inhibitors
R5137 T7373 T7369 Cause transactivation,Bcl-3
R5138 T7373 T7375 themeOf transactivation,inhibitors
R5141 T7387 T7394 themeOf IκB kinase,activation
R5144 T7388 T7392 themeOf IKK,degradation
R5145 T7388 T7395 themeOf IKK,activation
R5146 T7389 T7391 themeOf IκB protein,phosphorylation
R5148 T7389 T7393 themeOf IκB protein,degradation
R5149 T7390 T7387 SiteParent complex,IκB kinase
R5153 T7390 T7388 SiteParent complex,IKK
R5154 T7391 T7396 themeOf phosphorylation,mediates
R5155 T7392 T7397 themeOf degradation,mediates
R5158 T7393 T7398 themeOf degradation,mediates
R5160 T7394 T7390 Site activation,complex
R5161 T7395 T7390 Site activation,complex
R5163 T7396 T7388 Cause mediates,IKK
R5168 T7397 T7388 Cause mediates,IKK
R5171 T7398 T7388 Cause mediates,IKK
R5172 T7399 T7405 themeOf IKK complex,comprised
R5173 T7400 T7406 themeOf IKK1,comprised
R5174 T7401 T7407 themeOf IKK2,comprised
R5175 T7411 T7412 themeOf NF-κB,activation
R5176 T7412 T7413 themeOf activation,required
R5177 T7486 T7488 themeOf TRAF6,recruits
R5178 T7412 T7414 themeOf activation,required
R5179 T7487 T7489 themeOf RIP1,recruits
R5180 T7412 T7415 themeOf activation,required
R5181 T7488 T7485 Cause recruits,TRIF
R5182 T7413 T7408 Cause required,IKK2
R5183 T7489 T7485 Cause recruits,TRIF
R5184 T7490 T7493 themeOf TAK1,activate
R5185 T7491 T7494 themeOf IKK,activate
R5186 T7414 T7409 Cause required,NEMO
R5187 T7415 T7410 Cause required,IKK1
R5188 T7419 T7431 themeOf TNF receptor-1-associated death domain,recruitment
R5189 T7420 T7428 themeOf TRADD,recruitment
R5190 T7505 T7508 themeOf IKK1,dependent
R5191 T7505 T7509 themeOf IKK1,activated
R5192 T7505 T7510 themeOf IKK1,phosphorylation
R5193 T7420 T7432 themeOf TRADD,recruitment
R5194 T7507 T7511 themeOf NIK,phosphorylation
R5195 T7420 T7433 themeOf TRADD,recruitment
R5196 T7421 T7429 themeOf receptor interacting protein 1,recruitment
R5197 T7509 T7507 Cause activated,NIK
R5198 T7510 T7512 themeOf phosphorylation,activated
R5199 T7510 T7514 themeOf phosphorylation,activated
R5200 T7511 T7513 themeOf phosphorylation,activated
R5201 T7511 T7515 themeOf phosphorylation,activated
R5202 T7421 T7432 themeOf receptor interacting protein 1,recruitment
R5203 T7512 T7506 Cause activated,NF-κB inducing kinase
R5204 T7422 T7430 themeOf RIP1,recruitment
R5205 T7513 T7506 Cause activated,NF-κB inducing kinase
R5206 T7514 T7507 Cause activated,NIK
R5207 T7515 T7507 Cause activated,NIK
R5208 T7516 T7520 themeOf NIK,complex
R5209 T7516 T7521 themeOf NIK,complex
R5210 T7516 T7522 themeOf NIK,complex
R5211 T7516 T7523 themeOf NIK,degradation
R5212 T7517 T7520 themeOf TRAF2,complex
R5213 T7518 T7521 themeOf TRAF3,complex
R5214 T7519 T7522 themeOf cIAP1/2,complex
R5215 T7422 T7431 themeOf RIP1,recruitment
R5216 T7422 T7433 themeOf RIP1,recruitment
R5217 T7422 T7434 themeOf RIP1,associated
R5218 T7523 T7524 themeOf degradation,leading
R5219 T7424 T7434 themeOf TNF receptor,associated
R5220 T7525 T7528 themeOf TRAF3,remove
R5221 T7424 T7435 themeOf TNF receptor,associated
R5222 T7526 T7529 themeOf TRAF2,degradation
R5223 T7425 T7435 themeOf TRAF5,associated
R5224 T7527 T7530 themeOf cIAP1/2,degradation
R5225 T7436 T7440 themeOf TNF,stimulation
R5226 T7531 T7533 themeOf NIK,accumulation
R5227 T7532 T7534 themeOf IKK1,phosphorylation
R5228 T7533 T7535 themeOf accumulation,resulting
R5229 T7534 T7536 themeOf phosphorylation,resulting
R5230 T7534 T7537 themeOf phosphorylation,accumulation
R5231 T7542 T7554 themeOf CD40,binding
R5232 T7542 T7555 themeOf CD40,binding
R5233 T7542 T7556 themeOf CD40,binding
R5234 T7542 T7562 themeOf CD40,interact
R5235 T7542 T7563 themeOf CD40,interact
R5236 T7543 T7557 themeOf RANK,binding
R5237 T7543 T7558 themeOf RANK,binding
R5238 T7543 T7559 themeOf RANK,binding
R5239 T7454 T7455 themeOf NF-κB,activated
R5240 T7546 T7551 themeOf TRAF3,binding
R5241 T7546 T7554 themeOf TRAF3,binding
R5242 T7546 T7557 themeOf TRAF3,binding
R5243 T7546 T7560 themeOf TRAF3,binding
R5244 T7547 T7552 themeOf TRAF5,binding
R5245 T7547 T7555 themeOf TRAF5,binding
R5246 T7547 T7558 themeOf TRAF5,binding
R5247 T7547 T7561 themeOf TRAF5,binding
R5248 T7547 T7562 themeOf TRAF5,interact
R5249 T7548 T7553 themeOf TRAF6,binding
R5250 T7548 T7556 themeOf TRAF6,binding
R5251 T7548 T7559 themeOf TRAF6,binding
R5252 T7548 T7560 themeOf TRAF6,binding
R5253 T7548 T7561 themeOf TRAF6,binding
R5254 T7548 T7563 themeOf TRAF6,interact
R5255 T7549 T7564 themeOf TRAF2,proteolysis
R5256 T7550 T7565 themeOf TRAF3,proteolysis
R5257 T7564 T7566 themeOf proteolysis,leads
R5258 T7565 T7567 themeOf proteolysis,leads
R5259 T7568 T7570 themeOf TRAF molecules,associated
R5260 T7455 T7453 Cause activated,TNF
R5261 T7458 T7459 themeOf TAK1,activate
R5262 T7572 T7578 themeOf JNK,activation
R5263 T7573 T7579 themeOf IL-6,production
R5264 T7460 T7469 themeOf TLR4,stimulation
R5265 T7575 T7580 themeOf NF-κB,activation
R5266 T7461 T7470 themeOf Toll/IL-1 receptor adaptor protein,recruitment
R5267 T7578 T7581 themeOf activation,required
R5268 T7578 T7583 themeOf activation,mediated
R5269 T7579 T7582 themeOf production,required
R5270 T7579 T7584 themeOf production,activation
R5271 T7464 T7471 themeOf MyD88,recruit
R5272 T7580 T7585 themeOf activation,required
R5273 T7465 T7472 themeOf TIR,recruit
R5274 T7583 T7571 Cause mediated,CD40
R5275 T7465 T7475 themeOf TIR,recruit
R5276 T7585 T7574 Cause required,TRAF2
R5277 T7466 T7473 themeOf IFNβ,recruit
R5278 T7467 T7474 themeOf TRIF,recruit
R5279 T7467 T7475 themeOf TRIF,recruit
R5280 T7470 T7476 themeOf recruitment,induces
R5281 T7476 T7469 Cause induces,stimulation
R5284 T7477 T7482 themeOf MyD88,recruits
R5285 T7477 T7483 themeOf MyD88,recruits
R5286 T7479 T7482 themeOf IRAK,recruits
R5289 T7480 T7483 themeOf TRAF6,recruits
R5291 T7481 T7484 themeOf TRAF6,oligomerisation
R6275 T9189 T9191 themeOf NF-κB,activation
R6276 T9191 T9192 themeOf activation,regulation
R6277 T9194 T9195 themeOf NF-κB,activation
R6278 T9196 T9197 themeOf NF-κB,downregulate
R6279 T9200 T9201 themeOf NF-κB,role
R6280 T9208 T9212 themeOf IKK1,deficient
R6281 T9209 T9213 themeOf IKK1,expressing
R6282 T9210 T9214 themeOf IKK2,enhanced
R6283 T9211 T9215 themeOf IκBα degradation [34],enhanced
R6284 T9213 T9216 themeOf expressing,deficient
R6285 T9218 T9221 themeOf nuclear NF-κB,inhibit
R6286 T9219 T9220 themeOf STAT1,phosphorylating
R6287 T9221 T9220 Cause inhibit,phosphorylating
R6288 T9222 T9227 themeOf IKK1,phosphorylates
R6289 T9223 T9228 themeOf NIK,phosphorylates
R8131 T11929 T11935 themeOf NF-κB,inhibit
R8133 T11930 T11936 themeOf NF-κB,deubiquitinating
R8134 T11931 T11937 themeOf RIP1,deubiquitinating
R8135 T11931 T11941 themeOf RIP1,interactions
R8136 T11932 T11938 themeOf RIP2,deubiquitinating
R8138 T11933 T11939 themeOf TRAF6,deubiquitinating
R8139 T11934 T11940 themeOf MALT1,deubiquitinating
R8140 T11935 T11928 Cause inhibit,A20
R8141 T11949 T11950 themeOf NF-κB,downregulate
R8142 T11951 T11954 themeOf A20,association
R8143 T11952 T11955 themeOf NF-κB (ABIN) 1,inhibitor
R8144 T11953 T11956 themeOf Tax1-binding protein 1,inhibitor
R8145 T11957 T11959 themeOf NF-κB,activation
R8146 T11959 T11960 themeOf activation,suppressing
R8147 T11964 T11965 themeOf A20,expression
R8149 T11966 T11969 themeOf A20,expression
R8151 T11969 T11970 themeOf expression,regulated
R8156 T11970 T11967 Cause regulated,NF-κB
R8157 T11971 T11973 themeOf A20,expressing
R8158 T11974 T11984 themeOf A20,expression
R8160 T11976 T11985 themeOf TNF,decreased
R8164 T11977 T11986 themeOf IL-1β,decreased
R8166 T11978 T11987 themeOf IL-6,decreased
R8168 T11979 T11988 themeOf RANKL,decreased
R8169 T11980 T11989 themeOf IL-17,decreased
R8172 T11985 T11990 themeOf decreased,inhibition
R8176 T11986 T11991 themeOf decreased,inhibition
R8178 T11987 T11992 themeOf decreased,inhibition
R8179 T11988 T11993 themeOf decreased,inhibition
R8180 T11989 T11994 themeOf decreased,inhibition
R8181 T11997 T11999 themeOf TNF,decreased
R8185 T11998 T12000 themeOf IL-1β,decreased
R8187 T12001 T12002 themeOf A20,overexpression
R8188 T12002 T12003 themeOf overexpression,overexpression
R9222 T13763 T13764 themeOf NF-κB,inhibitors
R9223 T13768 T13771 themeOf A20 interacting proteins,expressed
R9224 T13769 T13772 themeOf NF-κB,activation
R9225 T13772 T13773 themeOf activation,inhibit
R9226 T13773 T13770 Cause inhibit,TNF
R9227 T13776 T13779 themeOf A20,role
R9228 T13777 T13780 themeOf ABIN,role
R9229 T13787 T13789 themeOf ABIN-1 mRNA,levels
R9230 T13790 T13794 themeOf TLR,inhibition
R9231 T13791 T13795 themeOf NF-κB,expression
R9232 T13792 T13796 themeOf proteins ABIN-3,expression
R9233 T13793 T13797 themeOf A20,expression
R9234 T13795 T13798 themeOf expression,depend
R9235 T13796 T13799 themeOf expression,depend
R9236 T13797 T13800 themeOf expression,depend
R9237 T13798 T13794 Cause depend,inhibition
R9238 T13799 T13794 Cause depend,inhibition
R9239 T13800 T13794 Cause depend,inhibition
R9240 T13801 T13802 themeOf ITAM,suppressed
R10062 T15117 T15135 themeOf NF-κB,regulates
R10063 T15117 T15136 themeOf NF-κB,regulates
R10064 T15117 T15137 themeOf NF-κB,regulates
R10065 T15117 T15138 themeOf NF-κB,regulates
R10066 T15117 T15139 themeOf NF-κB,regulates
R10067 T15117 T15140 themeOf NF-κB,regulates
R10068 T15117 T15141 themeOf NF-κB,regulates
R10069 T15121 T15128 themeOf NF-κB signalling proteins,deubiquitina-ting
R10070 T15122 T15129 themeOf NEMO,deubiquitina-ting
R10071 T15123 T15130 themeOf TRAF2,deubiquitina-ting
R10072 T15124 T15131 themeOf TRAF6,deubiquitina-ting
R10073 T15125 T15132 themeOf TRAF7,deubiquitina-ting
R10074 T15126 T15133 themeOf RIP1,deubiquitina-ting
R10075 T15127 T15134 themeOf TAK1,deubiquitina-ting
R10076 T15135 T15128 Cause regulates,deubiquitina-ting
R10077 T15136 T15129 Cause regulates,deubiquitina-ting
R10078 T15137 T15130 Cause regulates,deubiquitina-ting
R10079 T15138 T15131 Cause regulates,deubiquitina-ting
R10080 T15139 T15132 Cause regulates,deubiquitina-ting
R10081 T15140 T15133 Cause regulates,deubiquitina-ting
R10082 T15141 T15134 Cause regulates,deubiquitina-ting
R10083 T15143 T15144 themeOf NF-κB,activation
R10084 T15144 T15145 themeOf activation,control
R10085 T15145 T15142 Cause control,CYLD
R10086 T15146 T15147 themeOf NF-κB,regulates
R10087 T15149 T15150 themeOf RANK,regulate
R10088 T15150 T15148 Cause regulate,CYLD
R10089 T15151 T15152 themeOf CYLD,deficiency
R10090 T15154 T15160 themeOf CYLD,expression
R10091 T15160 T15161 themeOf expression,upregulated
R10092 T15160 T15162 themeOf expression,recruited
R10093 T15163 T15164 themeOf p62,expressing
R11316 T17106 T17107 themeOf ubiquitin ligase,lacks
R11317 T17107 T17104 Cause lacks,TRAF1
R11318 T17111 T17116 themeOf TRAF1,Expression
R11319 T17113 T17118 themeOf TRAF1,overexpression
R11320 T17116 T17117 themeOf Expression,inducible
R11321 T17117 T17112 Cause inducible,TNF
R11322 T17118 T17119 themeOf overexpression,overexpression
R11323 T17120 T17123 themeOf TRAF1,deficient
R11324 T17127 T17129 themeOf TRAF1,deficient
R11325 T17131 T17132 themeOf NF- κB,activation
R11326 T17132 T17133 themeOf activation,modulates
R11327 T17133 T17130 Cause modulates,TRAF1
R11328 T17134 T17136 themeOf TRAF1,binding
R11329 T17134 T17137 themeOf TRAF1,binding
R11330 T17135 T17137 themeOf TRAF,binding
R11331 T17138 T17139 themeOf TRAF1,interact
R11332 T17142 T17143 themeOf TRAF1,association
R12394 T18607 T18605 SiteParent "[79,80",NF-κB
R12395 T18607 T18606 SiteParent "[79,80",molecules IKKε and RIP1
R12396 T18608 T18610 themeOf miR-146,expressed
R12397 T18609 T18611 themeOf miR-155,expressed
R12398 T18612 T18614 themeOf miR-146a,overexpressed
R12399 T18613 T18615 themeOf CD4+,IL-17-producing
R12400 T18617 T18618 themeOf metalloproteinases,expression
R12401 T18618 T18619 themeOf expression,prevent
R12402 T18620 T18621 themeOf TNF,production
R12403 T18621 T18622 themeOf production,promote
R12404 T18624 T18626 themeOf miR-124a,decreased
R12405 T18627 T18629 themeOf matrix metalloproteinase-1,secretion
R12406 T18628 T18630 themeOf IL-6,secretion
R12407 T18629 T18631 themeOf secretion,leading
R12408 T18629 T18633 themeOf secretion,increased
R12409 T18630 T18632 themeOf secretion,leading
R12410 T18630 T18634 themeOf secretion,increased
R12604 T19045 T19046 themeOf NF-κB,activation
R12605 T19047 T19048 themeOf NF-κB,regulation
R13788 T20855 T20857 causeOf inhibiting,regulate
R13789 T20856 T20858 causeOf inhibiting,regulate
R13790 T20859 T20863 themeOf TLR,inhibited
R13791 T20860 T20864 themeOf TLR4,compete
R14523 T22255 T22257 themeOf NF-κB inducing kinase,expression
R14524 T22256 T22258 themeOf NIK,expression
R14525 T22257 T22259 themeOf expression,dependent
R14526 T22258 T22260 themeOf expression,dependent
R14527 T22265 T22267 themeOf NIK,degradation
R14528 T22268 T22271 themeOf TRAF3,binding
R14529 T22268 T22272 themeOf TRAF3,recruited
R14530 T22275 T22278 themeOf TRAF3,degraded
R14531 T22277 T22279 themeOf NIK,increased
R14532 T22280 T22284 themeOf NIK,phosphorylates
R14533 T22281 T22285 themeOf IKK1,activates
R14534 T22282 T22286 themeOf NF-κB,phosphorylation
R14535 T22283 T22287 themeOf p100,phosphorylation
R14536 T22285 T22280 Cause activates,NIK
R14537 T22286 T22288 themeOf phosphorylation,mediates
R14538 T22287 T22289 themeOf phosphorylation,mediates
R14539 T22288 T22281 Cause mediates,IKK1
R14540 T22289 T22281 Cause mediates,IKK1
R14541 T22290 T22293 themeOf p100,degradation
R14542 T22291 T22294 themeOf p52,degradation
R14543 T22292 T22295 themeOf RelB,heterodimer
R14544 T22297 T22299 themeOf TRAF1,competing
R14545 T22298 T22299 themeOf TNF receptor-associated factors,competing
R10427 T15788 T15796 themeOf Single-immunoglobulin IL-1 receptor,interaction
R10429 T15794 T15796 themeOf IRAK1,interaction
R10428 T15788 T15797 themeOf Single-immunoglobulin IL-1 receptor,interaction
R10430 T15795 T15797 themeOf TRAF6,interaction
R10431 T15796 T15798 themeOf interaction,inhibitor
R10432 T15797 T15799 themeOf interaction,inhibitor
R10433 T15800 T15803 themeOf IL-1R,role
R10434 T15801 T15804 themeOf TLR,role
R10435 T15805 T15806 themeOf SIGIRR,overexpression
R10436 T15806 T15807 themeOf overexpression,overexpression
R10437 T15811 T15812 themeOf SIGIRR,expression
R13760 T20811 T20817 themeOf RIP1,polyubiquitination
R13761 T20812 T20818 themeOf IRAK1,polyubiquitination
R13762 T20812 T20819 themeOf IRAK1,recruitment
R13763 T20816 T20819 themeOf TAK1,recruitment
R13764 T20820 T20823 themeOf TAK1,phosphorylates
R13765 T20820 T20824 causeOf TAK1,activates
R13766 T20821 T20824 themeOf IKK2,activates
R13767 T20821 T20825 themeOf IKK2,phosphorylates
R13768 T20822 T20826 themeOf IκBα,phosphorylates
R13769 T20822 T20827 themeOf IκBα,degradation
R13770 T20827 T20828 themeOf degradation,triggering
R13771 T20829 T20833 themeOf NF-κB,translocate
R13772 T20832 T20833 locationOf nucleus,translocate
R13773 T20836 T20838 themeOf NF-κB,activation
R13774 T20837 T20839 themeOf TRAFs,competing
R13775 T20838 T20840 themeOf activation,regulate
R13776 T20839 T20840 causeOf competing,regulate
R13777 T20841 T20848 causeOf A20,control
R13778 T20842 T20849 causeOf CYLD,control
R13779 T20843 T20847 themeOf NF-κB,activation
R13780 T20847 T20848 themeOf activation,control
R13781 T20847 T20849 themeOf activation,control
R13782 T20850 T20857 themeOf TLR,regulate
R13783 T20850 T20858 themeOf TLR,regulate
R13784 T20851 T20853 themeOf IRAK1,expression
R13785 T20852 T20854 themeOf TRAF6,expression
R13786 T20853 T20855 themeOf expression,inhibiting
R13787 T20854 T20856 themeOf expression,inhibiting
R13792 T20861 T20865 themeOf IRAK1,binding
R13793 T20862 T20866 themeOf TRAF6,binding

test3

Id Subject Object Predicate Lexical cue
T19395 8731-8777 Protein denotes TNF receptor 1-associated death domain protein
T19394 8689-8700 Binding denotes recruitment
T19393 8677-8684 Positive_regulation denotes trigger
T21400 15143-15165 Protein denotes tumour necrosis factor
T21399 15138-15141 Protein denotes TNF
T21398 15071-15098 Protein denotes receptor activator of NF-κB
T21397 15065-15069 Protein denotes RANK
T21396 14846-14851 Protein denotes TRAF1
T21395 14839-14844 Protein denotes TRAF3
T21394 14799-14803 Protein denotes RelB
T21393 14763-14766 Protein denotes p52
T21392 14755-14759 Protein denotes p100
T21391 14740-14751 Protein_catabolism denotes degradation
T21390 14649-14664 Phosphorylation denotes phosphorylation
T21389 14644-14648 Protein denotes p100
T21388 14629-14637 Positive_regulation denotes mediates
T21387 14617-14621 Protein denotes IKK1
T21386 14607-14616 Positive_regulation denotes activates
T21385 14579-14582 Protein denotes NIK
T21384 14555-14558 Protein denotes NIK
T21383 14513-14516 Protein denotes NIK
T21382 14500-14508 Protein_catabolism denotes degraded
T21381 14491-14496 Protein denotes TRAF3
T21380 14473-14476 Protein denotes NIK
T21379 14454-14459 Protein denotes TRAF3
T21378 14407-14408 Protein denotes 2
T21377 14401-14406 Protein denotes cIAP1
T21376 14354-14355 Protein denotes 2
T21375 14348-14353 Protein denotes cIAP1
T21374 14286-14291 Protein denotes TRAF2
T21373 14253-14262 Binding denotes recruited
T21372 14244-14249 Protein denotes TRAF3
T21371 14235-14242 Binding denotes binding
T21370 14207-14210 Protein denotes NIK
T21369 14194-14197 Protein denotes NIK
T21368 14179-14190 Protein_catabolism denotes degradation
T21367 14108-14109 Protein denotes 2
T21366 14102-14107 Protein denotes cIAP1
T21365 14092-14097 Protein denotes TRAF3
T21364 14085-14090 Protein denotes TRAF2
T21363 14028-14031 Protein denotes NIK
T21362 13982-13985 Protein denotes NIK
T21361 13959-13980 Protein denotes NF-κB inducing kinase
T21360 13889-13893 Protein denotes RANK
T21359 13880-13884 Protein denotes CD40
T21358 15143-15165 Protein denotes tumour necrosis factor
T21357 15138-15141 Protein denotes TNF
T21356 15071-15098 Protein denotes receptor activator of NF-κB
T21355 15065-15069 Protein denotes RANK
T21354 14846-14851 Protein denotes TRAF1
T21353 14839-14844 Protein denotes TRAF3
T21352 14799-14803 Protein denotes RelB
T21351 14763-14766 Protein denotes p52
T21350 14755-14759 Protein denotes p100
T21349 14644-14648 Protein denotes p100
T21348 14617-14621 Protein denotes IKK1
T21347 14579-14582 Protein denotes NIK
T21346 14555-14558 Protein denotes NIK
T21345 14513-14516 Protein denotes NIK
T21344 14491-14496 Protein denotes TRAF3
T21343 14473-14476 Protein denotes NIK
T21342 14454-14459 Protein denotes TRAF3
T21341 14407-14408 Protein denotes 2
T21340 14401-14406 Protein denotes cIAP1
T21339 14354-14355 Protein denotes 2
T21338 14348-14353 Protein denotes cIAP1
T21337 14286-14291 Protein denotes TRAF2
T21336 14244-14249 Protein denotes TRAF3
T21335 14207-14210 Protein denotes NIK
T21334 14194-14197 Protein denotes NIK
T21333 14108-14109 Protein denotes 2
T21332 14102-14107 Protein denotes cIAP1
T21331 14092-14097 Protein denotes TRAF3
T21330 14085-14090 Protein denotes TRAF2
T21329 14028-14031 Protein denotes NIK
T21328 13982-13985 Protein denotes NIK
T21327 13959-13980 Protein denotes NF-κB inducing kinase
T21326 13889-13893 Protein denotes RANK
T21325 13880-13884 Protein denotes CD40
T19459 10701-10723 Protein denotes tumour necrosis factor
T19458 10696-10699 Protein denotes TNF
T19457 10558-10600 Protein denotes single-immunoglobulinIL-1 receptor-related
T19456 10550-10556 Protein denotes SIGIRR
T19455 10518-10548 Protein denotes receptor interacting protein 1
T19454 10512-10516 Protein denotes RIP1
T19453 10483-10510 Protein denotes receptor activator of NF-κB
T19452 10477-10481 Protein denotes RANK
T19451 10430-10455 Protein denotes NF-κB essential modulator
T19450 10424-10428 Protein denotes NEMO
T19449 10374-10422 Protein denotes myeloid differentiation primary response gene 88
T19448 10367-10372 Protein denotes MyD88
T19447 10277-10292 Protein denotes cylindromatosis
T19446 10271-10275 Protein denotes CYLD
T19445 10200-10230 Protein denotes A20-binding inhibitor of NF-κB
T19444 10194-10198 Protein denotes ABIN
T19443 10031-10036 Protein denotes TRAF6
T19442 10021-10026 Protein denotes IRAK1
T19441 10010-10017 Binding denotes binding
T19440 10001-10005 Protein denotes TLR4
T19439 9988-9995 Negative_regulation denotes compete
T19438 9953-9959 Protein denotes SIGIRR
T19437 9914-9923 Negative_regulation denotes inhibited
T19436 9871-9876 Protein denotes TRAF6
T19435 9861-9866 Protein denotes IRAK1
T19434 9847-9857 Gene_expression denotes expression
T19433 9836-9846 Negative_regulation denotes inhibiting
T19432 9771-9774 Protein denotes p62
T19431 9760-9766 Protein denotes ABIN-1
T19430 9727-9734 Binding denotes binding
T19429 9692-9701 Binding denotes recruited
T19428 9667-9672 Protein denotes TRAF6
T19427 9658-9662 Protein denotes RIP1
T19426 9542-9546 Protein denotes CYLD
T19425 9534-9537 Protein denotes A20
T19424 9400-9405 Protein denotes TRAF1
T19423 9356-9363 Entity denotes nucleus
T19422 9337-9348 Localization denotes translocate
T19421 9329-9332 Protein denotes p50
T19420 9321-9324 Protein denotes p65
T19419 9258-9269 Protein_catabolism denotes degradation
T19418 9195-9199 Protein denotes IκBα
T19417 9180-9194 Phosphorylation denotes phosphorylates
T19416 9160-9164 Protein denotes IKK2
T19415 9121-9125 Protein denotes TAK1
T19414 9115-9119 Protein denotes TAK1
T19413 9106-9110 Protein denotes IKK2
T19412 9063-9074 Binding denotes recruitment
T19411 9046-9055 Positive_regulation denotes resulting
T19410 9023-9027 Protein denotes NEMO
T19409 8999-9004 Protein denotes IRAK1
T19408 8990-8994 Protein denotes RIP1
T19407 8926-8931 Protein denotes cIAP2
T19406 8919-8924 Protein denotes cIAP1
T19405 8912-8917 Protein denotes TRAF6
T19404 8905-8910 Protein denotes TRAF2
T19403 8874-8879 Protein denotes IRAK4
T19402 8867-8872 Protein denotes IRAK1
T19401 8861-8865 Protein denotes RIP1
T19400 8844-8848 Protein denotes TRIF
T19399 8799-8842 Protein denotes TIR domain-containing adaptor-inducing IFNβ
T19398 8794-8797 Protein denotes MAL
T19397 8787-8792 Protein denotes MyD88
T19396 8779-8784 Protein denotes TRADD
T19392 8672-8676 Protein denotes TLR4
T19391 8662-8666 Protein denotes RANK
T19390 8656-8660 Protein denotes CD40
T19389 8649-8654 Protein denotes TNFR1
T19388 8599-8609 Binding denotes engagement
T19387 10701-10723 Protein denotes tumour necrosis factor
T19386 10696-10699 Protein denotes TNF
T19385 10558-10600 Protein denotes single-immunoglobulinIL-1 receptor-related
T19384 10550-10556 Protein denotes SIGIRR
T19383 10518-10548 Protein denotes receptor interacting protein 1
T19382 10512-10516 Protein denotes RIP1
T19381 10483-10510 Protein denotes receptor activator of NF-κB
T19380 10477-10481 Protein denotes RANK
T19379 10430-10455 Protein denotes NF-κB essential modulator
T19378 10424-10428 Protein denotes NEMO
T19377 10374-10422 Protein denotes myeloid differentiation primary response gene 88
T19376 10367-10372 Protein denotes MyD88
T19375 10277-10292 Protein denotes cylindromatosis
T19374 10271-10275 Protein denotes CYLD
T19373 10200-10230 Protein denotes A20-binding inhibitor of NF-κB
T19372 10194-10198 Protein denotes ABIN
T19371 10031-10036 Protein denotes TRAF6
T19370 10021-10026 Protein denotes IRAK1
T19369 10001-10005 Protein denotes TLR4
T19368 9953-9959 Protein denotes SIGIRR
T19367 9871-9876 Protein denotes TRAF6
T19366 9861-9866 Protein denotes IRAK1
T19365 9771-9774 Protein denotes p62
T19364 9760-9766 Protein denotes ABIN-1
T19363 9667-9672 Protein denotes TRAF6
T19362 9658-9662 Protein denotes RIP1
T19361 9542-9546 Protein denotes CYLD
T19360 9534-9537 Protein denotes A20
T19359 9400-9405 Protein denotes TRAF1
T19358 9329-9332 Protein denotes p50
T19357 9321-9324 Protein denotes p65
T19356 9195-9199 Protein denotes IκBα
T19355 9160-9164 Protein denotes IKK2
T19354 9121-9125 Protein denotes TAK1
T19353 9115-9119 Protein denotes TAK1
T19352 9106-9110 Protein denotes IKK2
T19351 9023-9027 Protein denotes NEMO
T19350 8999-9004 Protein denotes IRAK1
T19349 8990-8994 Protein denotes RIP1
T19348 8926-8931 Protein denotes cIAP2
T19347 8919-8924 Protein denotes cIAP1
T19346 8912-8917 Protein denotes TRAF6
T19345 8905-8910 Protein denotes TRAF2
T19344 8874-8879 Protein denotes IRAK4
T19343 8867-8872 Protein denotes IRAK1
T19342 8861-8865 Protein denotes RIP1
T19341 8844-8848 Protein denotes TRIF
T19340 8799-8842 Protein denotes TIR domain-containing adaptor-inducing IFNβ
T19339 8794-8797 Protein denotes MAL
T19338 8787-8792 Protein denotes MyD88
T19337 8779-8784 Protein denotes TRADD
T19336 8731-8777 Protein denotes TNF receptor 1-associated death domain protein
T19335 8672-8676 Protein denotes TLR4
T19334 8662-8666 Protein denotes RANK
T19333 8656-8660 Protein denotes CD40
T19332 8649-8654 Protein denotes TNFR1
T17432 32702-32712 Gene_expression denotes expression
T17431 32659-32666 Protein denotes miR-223
T17430 32646-32653 Protein denotes miR-132
T17429 32638-32644 Protein denotes miR-16
T17428 32575-32579 Protein denotes IL-6
T17427 32544-32570 Protein denotes matrix metalloproteinase-1
T17426 32531-32540 Gene_expression denotes secretion
T17425 32521-32530 Positive_regulation denotes increased
T17424 32500-32507 Protein denotes miR-203
T17423 32481-32489 Positive_regulation denotes elevated
T17422 32368-32402 Protein denotes monocyte chemoattractant protein 1
T17421 32341-32350 Regulation denotes regulator
T17420 32324-32332 Protein denotes miR-124a
T17419 32152-32159 Protein denotes miR-155
T17418 31934-31944 Gene_expression denotes expression
T17417 31754-31761 Protein denotes miR-155
T17416 31684-31694 Gene_expression denotes production
T17415 31680-31683 Protein denotes TNF
T17414 31672-31679 Positive_regulation denotes promote
T17413 31651-31658 Protein denotes miR-155
T17412 31450-31457 Protein denotes miR-155
T17411 31364-31372 Protein denotes miR-146a
T17410 31269-31278 Gene_expression denotes producing
T17409 31263-31268 Protein denotes IL-17
T17408 31254-31257 Protein denotes CD4
T17407 31220-31228 Protein denotes miR-146a
T17406 31055-31062 Protein denotes miR-155
T17405 31015-31019 Protein denotes RIP1
T17404 31006-31010 Protein denotes IKKε
T17403 30931-30938 Protein denotes miR-155
T17402 30894-30902 Protein denotes miR-146a
T17401 30853-30858 Protein denotes TRAF6
T17400 30843-30848 Protein denotes IRAK1
T17399 30771-30779 Protein denotes miR-146a
T17398 30736-30739 Protein denotes TNF
T17397 30729-30734 Protein denotes IL-1β
T17396 30689-30696 Positive_regulation denotes induced
T17395 30590-30597 Protein denotes miR-155
T17394 30584-30585 Protein denotes b
T17393 30575-30583 Protein denotes miR-146a
T17392 30444-30448 Binding denotes bind
T17391 32659-32666 Protein denotes miR-223
T17390 32646-32653 Protein denotes miR-132
T17389 32638-32644 Protein denotes miR-16
T17388 32575-32579 Protein denotes IL-6
T17387 32544-32570 Protein denotes matrix metalloproteinase-1
T17386 32500-32507 Protein denotes miR-203
T17385 32368-32402 Protein denotes monocyte chemoattractant protein 1
T17384 32324-32332 Protein denotes miR-124a
T17383 32152-32159 Protein denotes miR-155
T17382 31754-31761 Protein denotes miR-155
T17381 31680-31683 Protein denotes TNF
T17380 31651-31658 Protein denotes miR-155
T17379 31450-31457 Protein denotes miR-155
T17378 31364-31372 Protein denotes miR-146a
T17377 31263-31268 Protein denotes IL-17
T17376 31254-31257 Protein denotes CD4
T17375 31220-31228 Protein denotes miR-146a
T17374 31055-31062 Protein denotes miR-155
T17373 31015-31019 Protein denotes RIP1
T17372 31006-31010 Protein denotes IKKε
T17371 30931-30938 Protein denotes miR-155
T17370 30894-30902 Protein denotes miR-146a
T17369 30853-30858 Protein denotes TRAF6
T17368 30843-30848 Protein denotes IRAK1
T17367 30771-30779 Protein denotes miR-146a
T17366 30736-30739 Protein denotes TNF
T17365 30729-30734 Protein denotes IL-1β
T17364 30590-30597 Protein denotes miR-155
T17363 30584-30585 Protein denotes b
T17362 30575-30583 Protein denotes miR-146a
T16340 29029-29034 Protein denotes TRAF1
T16339 29015-29025 Gene_expression denotes Expression
T16338 28862-28867 Protein denotes TRAF1
T16337 28798-28807 Protein denotes ubiquitin
T16336 28688-28693 Protein denotes TRAF1
T16335 30190-30195 Protein denotes TRAF1
T16334 30057-30062 Protein denotes TRAF1
T16333 29955-29960 Protein denotes TRAF1
T16332 29728-29731 Protein denotes A20
T16331 29708-29713 Protein denotes TRAF1
T16330 29595-29600 Protein denotes TRAF1
T16329 29528-29533 Protein denotes TRAF1
T16328 29426-29431 Protein denotes TRAF2
T16327 29330-29335 Protein denotes TRAF1
T16326 29299-29303 Protein denotes CD40
T16325 29251-29256 Protein denotes TRAF1
T16324 29170-29173 Protein denotes TNF
T16323 29122-29127 Protein denotes TRAF1
T16322 29092-29095 Protein denotes TNF
T16321 29077-29082 Protein denotes TRAF1
T16320 29051-29054 Protein denotes TNF
T16319 29029-29034 Protein denotes TRAF1
T16318 28862-28867 Protein denotes TRAF1
T16317 28798-28807 Protein denotes ubiquitin
T16316 28688-28693 Protein denotes TRAF1
T16315 28655-28687 Protein denotes TNF receptor-associated factor 1
T16362 30190-30195 Protein denotes TRAF1
T16361 30171-30182 Binding denotes association
T16360 30057-30062 Protein denotes TRAF1
T16359 29955-29960 Protein denotes TRAF1
T16358 29728-29731 Protein denotes A20
T16357 29708-29713 Protein denotes TRAF1
T16356 29639-29646 Binding denotes binding
T16355 29595-29600 Protein denotes TRAF1
T16354 29528-29533 Protein denotes TRAF1
T16353 29426-29431 Protein denotes TRAF2
T16352 29336-29345 Negative_regulation denotes deficient
T16351 29330-29335 Protein denotes TRAF1
T16350 29299-29303 Protein denotes CD40
T16349 29251-29256 Protein denotes TRAF1
T16348 29170-29173 Protein denotes TNF
T16347 29128-29137 Negative_regulation denotes deficient
T16346 29122-29127 Protein denotes TRAF1
T16345 29092-29095 Protein denotes TNF
T16344 29077-29082 Protein denotes TRAF1
T16343 29059-29073 Positive_regulation denotes overexpression
T16342 29051-29054 Protein denotes TNF
T16341 29038-29047 Positive_regulation denotes inducible
T15482 28594-28600 Protein denotes SIGIRR
T15481 28510-28516 Protein denotes SIGIRR
T15480 28436-28446 Gene_expression denotes expression
T15479 28405-28411 Protein denotes SIGIRR
T15478 28391-28401 Gene_expression denotes expression
T15477 28219-28228 Negative_regulation denotes deficient
T15476 28212-28218 Protein denotes SIGIRR
T15475 28168-28174 Protein denotes SIGIRR
T15474 28019-28025 Protein denotes SIGIRR
T15473 27898-27907 Gene_expression denotes expressed
T15472 27843-27849 Protein denotes SIGIRR
T15471 27813-27819 Protein denotes SIGIRR
T15470 27717-27722 Protein denotes IL-1R
T15469 27666-27671 Protein denotes TRAF6
T15468 27657-27662 Protein denotes IRAK1
T15467 27650-27655 Protein denotes MyD88
T15466 27616-27627 Binding denotes interaction
T15465 27566-27571 Protein denotes IL-1R
T15464 27553-27562 Negative_regulation denotes inhibitor
T15463 27464-27469 Protein denotes TIR-8
T15462 27433-27439 Protein denotes SIGIRR
T15461 27388-27431 Protein denotes Single-immunoglobulin IL-1 receptor-related
T15460 27336-27379 Protein denotes Single-immunoglobulin IL-1 receptor-related
T15459 28594-28600 Protein denotes SIGIRR
T15458 28510-28516 Protein denotes SIGIRR
T15457 28405-28411 Protein denotes SIGIRR
T15456 28212-28218 Protein denotes SIGIRR
T15455 28168-28174 Protein denotes SIGIRR
T15454 28019-28025 Protein denotes SIGIRR
T15453 27843-27849 Protein denotes SIGIRR
T15452 27813-27819 Protein denotes SIGIRR
T15451 27717-27722 Protein denotes IL-1R
T15450 27666-27671 Protein denotes TRAF6
T15449 27657-27662 Protein denotes IRAK1
T15448 27650-27655 Protein denotes MyD88
T15447 27566-27571 Protein denotes IL-1R
T15446 27464-27469 Protein denotes TIR-8
T15445 27433-27439 Protein denotes SIGIRR
T15444 27388-27431 Protein denotes Single-immunoglobulin IL-1 receptor-related
T15443 27336-27379 Protein denotes Single-immunoglobulin IL-1 receptor-related
T14138 27244-27248 Protein denotes CYLD
T14137 27135-27139 Protein denotes RANK
T14136 27106-27110 Protein denotes CYLD
T14135 26993-26996 Protein denotes p62
T14134 26896-26901 Protein denotes TRAF6
T14133 26867-26875 Positive_regulation denotes mediated
T14132 26862-26866 Protein denotes CYLD
T14131 26824-26838 Protein denotes sequestosome 1
T14130 26805-26808 Protein denotes p62
T14129 26781-26788 Binding denotes binding
T14128 26771-26780 Protein denotes ubiquitin
T14127 26763-26766 Positive_regulation denotes via
T14126 26757-26762 Protein denotes TRAF6
T14125 26730-26739 Binding denotes recruited
T14124 26696-26703 Positive_regulation denotes induced
T14123 26690-26695 Protein denotes RANKL
T14122 26630-26634 Protein denotes CYLD
T14121 26559-26564 Protein denotes RANKL
T14120 26420-26424 Protein denotes CYLD
T14119 26333-26337 Protein denotes RANK
T14118 26290-26294 Protein denotes CYLD
T14117 26143-26147 Protein denotes CYLD
T14116 25997-26006 Gene_expression denotes expressed
T14115 25985-25988 Protein denotes A20
T14114 25948-25952 Protein denotes CYLD
T14113 25933-25936 Protein denotes A20
T14112 25884-25887 Protein denotes A20
T14111 25843-25847 Protein denotes TAK1
T14110 25834-25838 Protein denotes RIP1
T14109 25827-25832 Protein denotes TRAF7
T14108 25820-25825 Protein denotes TRAF6
T14107 25813-25818 Protein denotes TRAF2
T14106 25807-25811 Protein denotes NEMO
T14105 25674-25678 Protein denotes RANK
T14104 25588-25611 Protein denotes deubiquitinating enzyme
T14103 25578-25582 Protein denotes CYLD
T14102 25385-25389 Protein denotes CYLD
T14101 25279-25283 Protein denotes CYLD
T14100 25262-25277 Protein denotes Cylindromatosis
T14099 25238-25253 Protein denotes Cylindromatosis
T14098 27244-27248 Protein denotes CYLD
T14097 27135-27139 Protein denotes RANK
T14096 27106-27110 Protein denotes CYLD
T14095 26993-26996 Protein denotes p62
T14094 26896-26901 Protein denotes TRAF6
T14093 26862-26866 Protein denotes CYLD
T14092 26824-26838 Protein denotes sequestosome 1
T14091 26805-26808 Protein denotes p62
T14090 26771-26780 Protein denotes ubiquitin
T14089 26757-26762 Protein denotes TRAF6
T14088 26690-26695 Protein denotes RANKL
T14087 26630-26634 Protein denotes CYLD
T14086 26559-26564 Protein denotes RANKL
T14085 26420-26424 Protein denotes CYLD
T14084 26333-26337 Protein denotes RANK
T14083 26290-26294 Protein denotes CYLD
T14082 26143-26147 Protein denotes CYLD
T14081 25985-25988 Protein denotes A20
T14080 25948-25952 Protein denotes CYLD
T14079 25933-25936 Protein denotes A20
T14078 25884-25887 Protein denotes A20
T14077 25843-25847 Protein denotes TAK1
T14076 25834-25838 Protein denotes RIP1
T14075 25827-25832 Protein denotes TRAF7
T14074 25820-25825 Protein denotes TRAF6
T14073 25813-25818 Protein denotes TRAF2
T14072 25807-25811 Protein denotes NEMO
T14071 25674-25678 Protein denotes RANK
T14070 25588-25611 Protein denotes deubiquitinating enzyme
T14069 25578-25582 Protein denotes CYLD
T14068 25385-25389 Protein denotes CYLD
T14067 25279-25283 Protein denotes CYLD
T14066 25262-25277 Protein denotes Cylindromatosis
T14065 25238-25253 Protein denotes Cylindromatosis
T12639 24679-24685 Protein denotes ABIN-1
T12638 24537-24540 Protein denotes A20
T12637 24526-24532 Protein denotes ABIN-3
T12636 24482-24492 Gene_expression denotes expression
T12635 24239-24242 Protein denotes A20
T12634 24217-24223 Protein denotes ABIN-1
T12633 24208-24212 Regulation denotes role
T12632 24136-24142 Protein denotes ABIN-1
T12631 24121-24125 Positive_regulation denotes high
T12630 24080-24087 Positive_regulation denotes induced
T12629 24076-24079 Protein denotes TNF
T12628 24048-24054 Protein denotes ABIN-1
T12627 23962-23965 Protein denotes TNF
T12626 23922-23931 Negative_regulation denotes deficient
T12625 23915-23921 Protein denotes ABIN-1
T12624 23883-23886 Protein denotes TNF
T12623 23853-23859 Protein denotes ABIN-1
T12622 23848-23851 Protein denotes A20
T12621 23819-23834 Entity denotes -binding domain
T12620 23762-23789 Protein denotes truncated and inactive form
T12619 23717-23726 Gene_expression denotes expressed
T12618 23707-23713 Protein denotes ABIN-3
T12617 23560-23569 Positive_regulation denotes increased
T12616 23523-23532 Negative_regulation denotes deficient
T12615 23516-23522 Protein denotes ABIN-2
T12614 23502-23511 Negative_regulation denotes deficient
T12613 23495-23501 Protein denotes ABIN-1
T12612 23383-23386 Protein denotes A20
T12611 23315-23325 Gene_expression denotes expression
T12610 23308-23314 Protein denotes ABIN-3
T12609 23297-23303 Protein denotes ABIN-1
T12608 23292-23295 Protein denotes A20
T12607 23236-23239 Protein denotes A20
T12606 23229-23235 Binding denotes target
T12605 23080-23083 Protein denotes TNF
T12604 23066-23076 Positive_regulation denotes activation
T12603 23009-23012 Protein denotes A20
T12602 22999-23008 Gene_expression denotes expressed
T12601 22959-22965 Protein denotes TNIP-3
T12600 22947-22953 Protein denotes TNIP-2
T12599 22939-22945 Protein denotes TNIP-1
T12598 22917-22923 Protein denotes ABIN-3
T12597 22906-22912 Protein denotes ABIN-2
T12596 22898-22904 Protein denotes ABIN-1
T12595 22866-22869 Protein denotes A20
T12594 24679-24685 Protein denotes ABIN-1
T12593 24537-24540 Protein denotes A20
T12592 24526-24532 Protein denotes ABIN-3
T12591 24239-24242 Protein denotes A20
T12590 24217-24223 Protein denotes ABIN-1
T12589 24136-24142 Protein denotes ABIN-1
T12588 24076-24079 Protein denotes TNF
T12587 24048-24054 Protein denotes ABIN-1
T12586 23962-23965 Protein denotes TNF
T12585 23915-23921 Protein denotes ABIN-1
T12584 23883-23886 Protein denotes TNF
T12583 23853-23859 Protein denotes ABIN-1
T12582 23848-23851 Protein denotes A20
T12581 23762-23789 Protein denotes truncated and inactive form
T12580 23707-23713 Protein denotes ABIN-3
T12579 23516-23522 Protein denotes ABIN-2
T12578 23495-23501 Protein denotes ABIN-1
T12577 23383-23386 Protein denotes A20
T12576 23308-23314 Protein denotes ABIN-3
T12575 23297-23303 Protein denotes ABIN-1
T12574 23292-23295 Protein denotes A20
T12573 23236-23239 Protein denotes A20
T12572 23080-23083 Protein denotes TNF
T12571 23009-23012 Protein denotes A20
T12570 22959-22965 Protein denotes TNIP-3
T12569 22947-22953 Protein denotes TNIP-2
T12568 22939-22945 Protein denotes TNIP-1
T12567 22917-22923 Protein denotes ABIN-3
T12566 22906-22912 Protein denotes ABIN-2
T12565 22898-22904 Protein denotes ABIN-1
T12564 22866-22869 Protein denotes A20
T9631 22791-22794 Protein denotes A20
T9630 22555-22558 Protein denotes A20
T9629 22507-22510 Protein denotes A20
T9628 22327-22330 Protein denotes A20
T9627 22246-22249 Protein denotes A20
T9626 22208-22216 Protein denotes cytokine
T9625 22176-22179 Protein denotes TNF
T9624 22151-22154 Protein denotes TNF
T9623 22116-22119 Protein denotes A20
T9622 22029-22032 Protein denotes A20
T9621 21982-21985 Protein denotes A20
T9620 21828-21831 Protein denotes A20
T9619 21607-21610 Protein denotes A20
T9618 21461-21464 Protein denotes A20
T9617 21257-21260 Protein denotes A20
T9616 21162-21165 Protein denotes A20
T9615 21013-21016 Protein denotes A20
T9614 21004-21009 Protein denotes IL-1β
T9613 20996-20999 Protein denotes TNF
T9612 20970-20979 Negative_regulation denotes decreased
T9611 20869-20874 Protein denotes IL-1β
T9610 20861-20864 Protein denotes TNF
T9609 20703-20706 Protein denotes A20
T9608 20639-20674 Protein denotes monocyte chemo-attractant protein 1
T9607 20632-20637 Protein denotes RANKL
T9606 20618-20622 Protein denotes IL-6
T9605 20611-20616 Protein denotes IL-1β
T9604 20606-20609 Protein denotes TNF
T9603 20586-20595 Negative_regulation denotes decreased
T9602 20499-20502 Protein denotes A20
T9601 20271-20274 Protein denotes A20
T9600 20168-20171 Protein denotes A20
T9599 20131-20140 Regulation denotes regulated
T9598 20110-20120 Gene_expression denotes expression
T9597 20106-20109 Protein denotes A20
T9596 19929-19932 Protein denotes A20
T9595 19798-19801 Protein denotes A20
T9594 19790-19797 Negative_regulation denotes lacking
T9593 19677-19680 Protein denotes A20
T9592 19643-19646 Protein denotes TNF
T9591 19483-19486 Protein denotes A20
T9590 19475-19482 Negative_regulation denotes lacking
T9589 19360-19363 Protein denotes TNF
T9588 19315-19324 Negative_regulation denotes deficient
T9587 19311-19314 Protein denotes A20
T9586 19126-19129 Protein denotes A20
T9585 19062-19065 Protein denotes A20
T9584 18964-18967 Protein denotes A20
T9583 18882-18904 Protein denotes Tax1-binding protein 1
T9582 18838-18877 Protein denotes A20-binding inhibitor of NF-κB (ABIN) 1
T9581 18802-18809 Binding denotes binding
T9580 18753-18756 Protein denotes A20
T9579 18738-18749 Binding denotes association
T9578 18691-18694 Protein denotes A20
T9577 18634-18635 Protein denotes 2
T9576 18628-18633 Protein denotes cIAP1
T9575 18618-18623 Protein denotes TRAF2
T9574 18611-18616 Protein denotes TRAF6
T9573 18577-18583 Protein denotes Ubc5hc
T9572 18567-18572 Protein denotes Ubc13
T9571 18451-18463 Binding denotes interactions
T9557 22555-22558 Protein denotes A20
T9556 22507-22510 Protein denotes A20
T9555 22327-22330 Protein denotes A20
T9554 22246-22249 Protein denotes A20
T9553 22208-22216 Protein denotes cytokine
T9552 22176-22179 Protein denotes TNF
T9551 22151-22154 Protein denotes TNF
T9550 22116-22119 Protein denotes A20
T9549 22029-22032 Protein denotes A20
T9548 21982-21985 Protein denotes A20
T9547 21828-21831 Protein denotes A20
T9546 21607-21610 Protein denotes A20
T9545 21461-21464 Protein denotes A20
T9544 21257-21260 Protein denotes A20
T9543 21162-21165 Protein denotes A20
T9542 21013-21016 Protein denotes A20
T9541 21004-21009 Protein denotes IL-1β
T9540 20996-20999 Protein denotes TNF
T9539 20869-20874 Protein denotes IL-1β
T9538 20861-20864 Protein denotes TNF
T9537 20703-20706 Protein denotes A20
T9536 20639-20674 Protein denotes monocyte chemo-attractant protein 1
T9535 20632-20637 Protein denotes RANKL
T9534 20618-20622 Protein denotes IL-6
T9533 20611-20616 Protein denotes IL-1β
T9532 20606-20609 Protein denotes TNF
T9531 20499-20502 Protein denotes A20
T9530 20271-20274 Protein denotes A20
T9529 20168-20171 Protein denotes A20
T9528 20106-20109 Protein denotes A20
T9527 19929-19932 Protein denotes A20
T9526 19798-19801 Protein denotes A20
T9525 19677-19680 Protein denotes A20
T9524 19643-19646 Protein denotes TNF
T9523 19483-19486 Protein denotes A20
T9522 19360-19363 Protein denotes TNF
T9521 19311-19314 Protein denotes A20
T9520 19126-19129 Protein denotes A20
T9519 19062-19065 Protein denotes A20
T9518 18964-18967 Protein denotes A20
T9517 18882-18904 Protein denotes Tax1-binding protein 1
T9516 18838-18877 Protein denotes A20-binding inhibitor of NF-κB (ABIN) 1
T9515 18753-18756 Protein denotes A20
T9514 18691-18694 Protein denotes A20
T9513 18634-18635 Protein denotes 2
T9512 18628-18633 Protein denotes cIAP1
T9511 18618-18623 Protein denotes TRAF2
T9510 18611-18616 Protein denotes TRAF6
T9509 18577-18583 Protein denotes Ubc5hc
T9508 18567-18572 Protein denotes Ubc13
T9507 18404-18409 Protein denotes MALT1
T9506 18394-18399 Protein denotes TRAF6
T9505 18388-18392 Protein denotes RIP2
T9504 18382-18386 Protein denotes RIP1
T9503 18275-18278 Protein denotes A20
T9502 18132-18135 Protein denotes TNF
T9501 18038-18043 Protein denotes NF-κB
T9500 17986-18011 Protein denotes ubiquitin-editing protein
T9499 17972-17979 Protein denotes TNFAIP3
T9498 17953-17956 Protein denotes A20
T9497 17941-17944 Protein denotes A20
T9570 18417-18425 Negative_regulation denotes disrupts
T9569 18404-18409 Protein denotes MALT1
T9568 18394-18399 Protein denotes TRAF6
T9567 18388-18392 Protein denotes RIP2
T9566 18382-18386 Protein denotes RIP1
T9565 18275-18278 Protein denotes A20
T9564 18132-18135 Protein denotes TNF
T9563 18038-18043 Protein denotes NF-κB
T9562 17986-18011 Protein denotes ubiquitin-editing protein
T9561 17972-17979 Protein denotes TNFAIP3
T9560 17953-17956 Protein denotes A20
T9559 17941-17944 Protein denotes A20
T9558 22791-22794 Protein denotes A20
T8378 17781-17785 Protein denotes IKK1
T8377 17680-17683 Protein denotes NIK
T8376 17660-17664 Protein denotes IKK1
T8375 17596-17601 Protein denotes STAT1
T8374 17480-17484 Protein denotes IKK1
T8373 17462-17473 Protein_catabolism denotes degradation
T8372 17457-17461 Protein denotes IκBα
T8371 17442-17452 Positive_regulation denotes activation
T8370 17437-17441 Protein denotes IKK2
T8369 17428-17436 Positive_regulation denotes enhanced
T8368 17353-17357 Protein denotes IKK1
T8367 17333-17343 Gene_expression denotes expressing
T8366 17302-17311 Negative_regulation denotes deficient
T8365 17297-17301 Protein denotes IKK1
T8364 17069-17073 Protein denotes IKK1
T8363 16915-16921 Protein denotes TOLLIP
T8362 16903-16909 Protein denotes IRAK-M
T8361 16895-16901 Protein denotes MyD88s
T8360 17781-17785 Protein denotes IKK1
T8359 17680-17683 Protein denotes NIK
T8358 17660-17664 Protein denotes IKK1
T8357 17596-17601 Protein denotes STAT1
T8356 17480-17484 Protein denotes IKK1
T8355 17457-17461 Protein denotes IκBα
T8354 17437-17441 Protein denotes IKK2
T8353 17353-17357 Protein denotes IKK1
T8352 17297-17301 Protein denotes IKK1
T8351 17069-17073 Protein denotes IKK1
T8350 16915-16921 Protein denotes TOLLIP
T8349 16903-16909 Protein denotes IRAK-M
T8348 16895-16901 Protein denotes MyD88s
T4235 15890-15894 Protein denotes CD40
T4234 15877-15886 Negative_regulation denotes regulator
T4233 15850-15855 Protein denotes TRAF3
T4232 15812-15820 Positive_regulation denotes required
T4231 15803-15808 Protein denotes TRAF2
T4230 15785-15795 Gene_expression denotes production
T4229 15780-15784 Protein denotes IL-6
T4228 15747-15751 Protein denotes CD40
T4227 15734-15742 Positive_regulation denotes required
T4226 15725-15730 Protein denotes TRAF6
T4225 15676-15680 Protein denotes CD40
T4224 15499-15504 Protein denotes TRAF3
T4223 15489-15494 Protein denotes TRAF2
T4222 15440-15445 Protein denotes TRAF6
T4221 15429-15434 Protein denotes TRAF5
T4220 15422-15427 Protein denotes TRAF3
T4219 15415-15420 Protein denotes TRAF2
T4218 15408-15413 Protein denotes TRAF1
T4217 15362-15370 Binding denotes interact
T4216 15357-15361 Protein denotes RANK
T4215 15348-15352 Protein denotes CD40
T4214 15323-15330 Binding denotes binding
T4213 15228-15232 Protein denotes RANK
T4212 15201-15223 Protein denotes lymphotoxin β receptor
T4211 15195-15199 Protein denotes CD40
T4210 13803-13818 Phosphorylation denotes phosphorylation
T4209 13798-13802 Protein denotes IKK1
T4208 13777-13780 Protein denotes NIK
T4207 13751-13762 Protein_catabolism denotes degradation
T4206 13725-13728 Protein denotes NIK
T4205 13678-13689 Protein_catabolism denotes degradation
T4204 13672-13677 Protein denotes TRAF3
T4203 13647-13656 Positive_regulation denotes essential
T4202 13634-13635 Protein denotes 2
T4201 13628-13633 Protein denotes cIAP1
T4200 13618-13623 Protein denotes TRAF2
T4199 13540-13545 Protein denotes TRAF3
T4198 13457-13468 Protein_catabolism denotes degradation
T4197 13426-13429 Protein denotes NIK
T4196 13395-13396 Protein denotes 2
T4195 13389-13394 Protein denotes cIAP1
T4194 13378-13383 Protein denotes TRAF3
T4193 13371-13376 Protein denotes TRAF2
T4192 13330-13333 Protein denotes NIK
T4191 13185-13188 Protein denotes NIK
T4190 13179-13182 Protein denotes NIK
T4189 13156-13177 Protein denotes NF-κB inducing kinase
T4188 13137-13152 Phosphorylation denotes phosphorylation
T4187 13122-13131 Positive_regulation denotes activated
T4186 13107-13111 Protein denotes IKK1
T4185 13094-13103 Regulation denotes dependent
T4184 12892-12896 Protein denotes RelB
T4183 12863-12866 Protein denotes p52
T4182 12824-12828 Protein denotes p100
T4181 12790-12794 Protein denotes RANK
T4180 12780-12784 Protein denotes CD40
T4179 12765-12778 Protein denotes BAFF receptor
T4178 12741-12763 Protein denotes lymphotoxin β receptor
T4177 12724-12733 Positive_regulation denotes activated
T4176 12662-12665 Protein denotes TNF
T4175 12597-12601 Protein denotes TAK1
T4133 11006-11045 Protein denotes TNF receptor-associated factor (TRAF) 2
T4132 10935-10939 Protein denotes RIP1
T4131 10903-10933 Protein denotes receptor interacting protein 1
T4130 10881-10886 Protein denotes TRADD
T4129 10841-10879 Protein denotes TNF receptor-1-associated death domain
T4128 10826-10837 Binding denotes recruitment
T4127 10795-10798 Protein denotes TNF
T4126 10782-10785 Protein denotes TNF
T4125 8474-8478 Protein denotes IKK1
T4124 8460-8464 Protein denotes NEMO
T4123 8451-8455 Protein denotes IKK2
T4122 8394-8398 Protein denotes IKKγ
T4121 8373-8377 Protein denotes NEMO
T4120 8346-8371 Protein denotes NF-κB essential modulator
T4119 8313-8317 Protein denotes IKKβ
T4118 8304-8308 Protein denotes IKKα
T4117 8284-8288 Protein denotes IKK2
T4116 8275-8279 Protein denotes IKK1
T4115 8180-8191 Protein_catabolism denotes degradation
T4114 8092-8107 Phosphorylation denotes phosphorylation
T4113 8083-8091 Positive_regulation denotes mediates
T4112 7830-7835 Protein denotes RANKL
T4111 7808-7811 Protein denotes TNF
T4110 7481-7484 Protein denotes p50
T4109 7473-7476 Protein denotes p52
T4108 7446-7450 Protein denotes p105
T4107 7437-7441 Protein denotes p100
T4106 7374-7379 Protein denotes Bcl-3
T4105 7365-7369 Protein denotes IκBξ
T4104 7344-7354 Negative_regulation denotes inhibitors
T4103 7326-7332 Protein denotes NF-κB2
T4102 7306-7310 Protein denotes p100
T4101 7297-7303 Protein denotes NF-κB1
T4100 7277-7281 Protein denotes p105
T4099 7271-7275 Protein denotes IκBε
T4098 7265-7269 Protein denotes IκBβ
T4097 7259-7263 Protein denotes IκBα
T4096 7193-7206 Localization denotes translocation
T4095 7171-7178 Negative_regulation denotes prevent
T4094 15890-15894 Protein denotes CD40
T4093 15850-15855 Protein denotes TRAF3
T4092 15803-15808 Protein denotes TRAF2
T4091 15780-15784 Protein denotes IL-6
T4090 15747-15751 Protein denotes CD40
T4089 15725-15730 Protein denotes TRAF6
T4088 15676-15680 Protein denotes CD40
T4087 15499-15504 Protein denotes TRAF3
T4086 15489-15494 Protein denotes TRAF2
T4085 15440-15445 Protein denotes TRAF6
T4084 15429-15434 Protein denotes TRAF5
T4083 15422-15427 Protein denotes TRAF3
T4082 15415-15420 Protein denotes TRAF2
T4081 15408-15413 Protein denotes TRAF1
T4080 15357-15361 Protein denotes RANK
T4079 15348-15352 Protein denotes CD40
T4078 15228-15232 Protein denotes RANK
T4077 15201-15223 Protein denotes lymphotoxin β receptor
T4076 15195-15199 Protein denotes CD40
T4075 13798-13802 Protein denotes IKK1
T4074 13777-13780 Protein denotes NIK
T4073 13725-13728 Protein denotes NIK
T4072 13672-13677 Protein denotes TRAF3
T4071 13634-13635 Protein denotes 2
T4070 13628-13633 Protein denotes cIAP1
T4069 13618-13623 Protein denotes TRAF2
T4068 13540-13545 Protein denotes TRAF3
T4067 13426-13429 Protein denotes NIK
T4066 13395-13396 Protein denotes 2
T4065 13389-13394 Protein denotes cIAP1
T4064 13378-13383 Protein denotes TRAF3
T4063 13371-13376 Protein denotes TRAF2
T4062 13330-13333 Protein denotes NIK
T4061 13185-13188 Protein denotes NIK
T4060 13179-13182 Protein denotes NIK
T4059 13156-13177 Protein denotes NF-κB inducing kinase
T4058 13107-13111 Protein denotes IKK1
T4057 12892-12896 Protein denotes RelB
T4056 12863-12866 Protein denotes p52
T4055 12824-12828 Protein denotes p100
T4054 12790-12794 Protein denotes RANK
T4053 12780-12784 Protein denotes CD40
T4052 12765-12778 Protein denotes BAFF receptor
T4051 12741-12763 Protein denotes lymphotoxin β receptor
T4050 12662-12665 Protein denotes TNF
T4049 12597-12601 Protein denotes TAK1
T4048 12533-12537 Protein denotes RIP1
T4047 12518-12523 Protein denotes TRAF6
T4046 12499-12503 Protein denotes TRIF
T4045 12487-12492 Protein denotes TRAF6
T4044 12427-12432 Protein denotes TRAF6
T4043 12347-12352 Protein denotes MyD88
T4042 12326-12330 Protein denotes TRIF
T4041 12281-12324 Protein denotes TIR domain-containing adaptor-inducing IFNβ
T4040 12270-12275 Protein denotes MyD88
T4039 12220-12268 Protein denotes myeloid differentiation primary response gene 88
T4038 12156-12160 Protein denotes TRAM
T4037 12125-12154 Protein denotes TRIF-related adaptor molecule
T4036 12116-12118 Protein denotes Ma
T4035 12060-12094 Protein denotes Toll/IL-1 receptor adaptor protein
T4034 11994-11998 Protein denotes TLR4
T4033 11906-11910 Protein denotes TAK1
T4032 11680-11683 Protein denotes TNF
T4031 11621-11625 Protein denotes NEMO
T4030 11529-11530 Protein denotes 2
T4029 11524-11528 Protein denotes TAB1
T4028 11515-11519 Protein denotes NEMO
T4027 11467-11471 Protein denotes TAK1
T4026 11405-11409 Protein denotes RIP1
T4025 11308-11312 Protein denotes RIP1
T4024 11282-11283 Protein denotes 2
T4023 11276-11281 Protein denotes cIAP1
T4022 11270-11271 Protein denotes 5
T4021 11264-11269 Protein denotes TRAF2
T4020 11203-11207 Protein denotes RIP1
T4019 11167-11170 Protein denotes TNF
T4018 11146-11151 Protein denotes cIAP2
T4017 11101-11141 Protein denotes cellular inhibitor of apoptosis (cIAP) 1
T4016 11050-11055 Protein denotes TRAF5
T4015 11006-11045 Protein denotes TNF receptor-associated factor (TRAF) 2
T4014 10935-10939 Protein denotes RIP1
T4013 10903-10933 Protein denotes receptor interacting protein 1
T4012 10881-10886 Protein denotes TRADD
T4011 10841-10879 Protein denotes TNF receptor-1-associated death domain
T4010 10795-10798 Protein denotes TNF
T4009 10782-10785 Protein denotes TNF
T4008 8474-8478 Protein denotes IKK1
T4007 8460-8464 Protein denotes NEMO
T4006 8451-8455 Protein denotes IKK2
T4005 8394-8398 Protein denotes IKKγ
T4004 8373-8377 Protein denotes NEMO
T4003 8346-8371 Protein denotes NF-κB essential modulator
T4002 8313-8317 Protein denotes IKKβ
T4001 8304-8308 Protein denotes IKKα
T4000 8284-8288 Protein denotes IKK2
T3999 8275-8279 Protein denotes IKK1
T3998 7830-7835 Protein denotes RANKL
T3997 7808-7811 Protein denotes TNF
T3996 7481-7484 Protein denotes p50
T3995 7473-7476 Protein denotes p52
T3994 7446-7450 Protein denotes p105
T3993 7437-7441 Protein denotes p100
T3992 7374-7379 Protein denotes Bcl-3
T3991 7365-7369 Protein denotes IκBξ
T3990 7326-7332 Protein denotes NF-κB2
T3989 7306-7310 Protein denotes p100
T3988 7297-7303 Protein denotes NF-κB1
T3987 7277-7281 Protein denotes p105
T3986 7271-7275 Protein denotes IκBε
T3985 7265-7269 Protein denotes IκBβ
T3984 7259-7263 Protein denotes IκBα
T4174 12556-12567 Binding denotes interaction
T4173 12533-12537 Protein denotes RIP1
T4172 12518-12523 Protein denotes TRAF6
T4171 12509-12517 Binding denotes recruits
T4170 12499-12503 Protein denotes TRIF
T4169 12487-12492 Protein denotes TRAF6
T4168 12427-12432 Protein denotes TRAF6
T4167 12347-12352 Protein denotes MyD88
T4166 12326-12330 Protein denotes TRIF
T4165 12281-12324 Protein denotes TIR domain-containing adaptor-inducing IFNβ
T4164 12270-12275 Protein denotes MyD88
T4163 12220-12268 Protein denotes myeloid differentiation primary response gene 88
T4162 12156-12160 Protein denotes TRAM
T4161 12125-12154 Protein denotes TRIF-related adaptor molecule
T4160 12116-12119 Protein denotes Mal
T4159 12060-12094 Protein denotes Toll/IL-1 receptor adaptor protein
T4158 12045-12056 Binding denotes recruitment
T4157 12033-12040 Positive_regulation denotes induces
T4156 11994-11998 Protein denotes TLR4
T4155 11906-11910 Protein denotes TAK1
T4154 11680-11683 Protein denotes TNF
T4153 11621-11625 Protein denotes NEMO
T4152 11529-11530 Protein denotes 2
T4151 11524-11528 Protein denotes TAB1
T4150 11515-11519 Protein denotes NEMO
T4149 11498-11505 Binding denotes binding
T4148 11467-11471 Protein denotes TAK1
T4147 11447-11454 Binding denotes recruit
T4146 11405-11409 Protein denotes RIP1
T4145 11308-11312 Protein denotes RIP1
T4144 11282-11283 Protein denotes 2
T4143 11276-11281 Protein denotes cIAP1
T4142 11270-11271 Protein denotes 5
T4141 11264-11269 Protein denotes TRAF2
T4140 11203-11207 Protein denotes RIP1
T4139 11197-11202 Binding denotes bound
T4138 11167-11170 Protein denotes TNF
T4137 11146-11151 Protein denotes cIAP2
T4136 11101-11141 Protein denotes cellular inhibitor of apoptosis (cIAP) 1
T4135 11071-11075 Binding denotes bind
T4134 11050-11055 Protein denotes TRAF5
T1746 6759-6769 Protein denotes tenascin C
T1745 6749-6757 Protein denotes biglycan
T1744 6736-6747 Protein denotes fibronectin
T1743 6565-6569 Protein denotes TLR4
T1742 6341-6367 Protein denotes myeloid-related protein 14
T1741 6311-6336 Protein denotes Myeloid-related protein 8
T1740 6248-6253 Protein denotes HMGB1
T1739 6183-6188 Protein denotes HMGB1
T1738 6138-6143 Protein denotes HMGB1
T1737 6099-6111 Protein denotes TLR4 ligands
T1736 6032-6040 Localization denotes released
T1735 5954-5973 Protein denotes chromatin component
T1734 5927-5932 Protein denotes HMGB1
T1733 5880-5925 Protein denotes High mobility group box chromosomal protein 1
T1732 5011-5033 Protein denotes lymphotoxin β receptor
T1731 4957-4961 Protein denotes BAFF
T1730 4882-4891 Gene_expression denotes producing
T1729 4836-4840 Protein denotes BAFF
T1728 4810-4834 Protein denotes B-cell activating factor
T1727 4765-4775 Gene_expression denotes expression
T1726 4756-4764 Positive_regulation denotes Enhanced
T1725 4576-4580 Protein denotes CD40
T1724 4302-4305 Protein denotes CD4
T1723 4264-4273 Gene_expression denotes expressed
T1722 4235-4240 Protein denotes CD154
T1721 4222-4233 Protein denotes CD40 ligand
T1720 4207-4214 Binding denotes Binding
T1719 4197-4200 Protein denotes TNF
T1718 3967-3976 Gene_expression denotes expressed
T1717 3919-3945 Protein denotes TNF receptor family member
T1716 3903-3907 Protein denotes CD40
T1715 3789-3793 Protein denotes RANK
T1714 3693-3697 Protein denotes RANK
T1713 3664-3691 Protein denotes receptor activator of NF-κB
T1712 3450-3453 Protein denotes TNF
T1711 3375-3378 Protein denotes TNF
T1710 3316-3319 Protein denotes TNF
T1709 6759-6769 Protein denotes tenascin C
T1708 6749-6757 Protein denotes biglycan
T1707 6736-6747 Protein denotes fibronectin
T1706 6565-6569 Protein denotes TLR4
T1705 6341-6367 Protein denotes myeloid-related protein 14
T1704 6311-6336 Protein denotes Myeloid-related protein 8
T1703 6248-6253 Protein denotes HMGB1
T1702 6183-6188 Protein denotes HMGB1
T1701 6138-6143 Protein denotes HMGB1
T1700 6099-6111 Protein denotes TLR4 ligands
T1699 5954-5973 Protein denotes chromatin component
T1698 5927-5932 Protein denotes HMGB1
T1697 5880-5925 Protein denotes High mobility group box chromosomal protein 1
T1696 5011-5033 Protein denotes lymphotoxin β receptor
T1695 4957-4961 Protein denotes BAFF
T1694 4836-4840 Protein denotes BAFF
T1693 4810-4834 Protein denotes B-cell activating factor
T1692 4576-4580 Protein denotes CD40
T1691 4302-4305 Protein denotes CD4
T1690 4235-4240 Protein denotes CD154
T1689 4222-4233 Protein denotes CD40 ligand
T1688 4197-4200 Protein denotes TNF
T1687 3919-3945 Protein denotes TNF receptor family member
T1686 3903-3907 Protein denotes CD40
T1685 3789-3793 Protein denotes RANK
T1684 3693-3697 Protein denotes RANK
T1683 3664-3691 Protein denotes receptor activator of NF-κB
T1682 3450-3453 Protein denotes TNF
T1681 3375-3378 Protein denotes TNF
T1680 3316-3319 Protein denotes TNF
T320 2966-2971 Protein denotes c-REL
T319 2953-2960 Protein denotes TNFAIP3
T318 2946-2951 Protein denotes TRAF1
T317 2940-2944 Protein denotes CD40
T316 2690-2695 Protein denotes RANKL
T315 2654-2688 Protein denotes receptor activator of NF-κB ligand
T314 2035-2038 Protein denotes TNF
T313 1932-1963 Protein denotes inducible nitric oxide synthase
T312 1901-1918 Protein denotes cyclo-oxygenase-2
T311 1895-1899 Protein denotes IL-6
T310 1884-1887 Protein denotes TNF
T309 1836-1846 Gene_expression denotes expression
T308 1823-1831 Regulation denotes regulate
T307 1758-1763 Protein denotes c-Rel
T306 1752-1756 Protein denotes RelB
T305 1746-1750 Protein denotes RelA
T304 1739-1742 Protein denotes p65
T303 1731-1737 Protein denotes NF-κB1
T302 1723-1727 Protein denotes p105
T301 1715-1721 Protein denotes NF-κB2
T300 1707-1711 Protein denotes p100
T299 2966-2971 Protein denotes c-REL
T298 2953-2960 Protein denotes TNFAIP3
T297 2946-2951 Protein denotes TRAF1
T296 2940-2944 Protein denotes CD40
T295 2690-2695 Protein denotes RANKL
T294 2654-2688 Protein denotes receptor activator of NF-κB ligand
T293 2035-2038 Protein denotes TNF
T292 1932-1963 Protein denotes inducible nitric oxide synthase
T291 1901-1918 Protein denotes cyclo-oxygenase-2
T290 1895-1899 Protein denotes IL-6
T289 1884-1887 Protein denotes TNF
T288 1758-1763 Protein denotes c-Rel
T287 1752-1756 Protein denotes RelB
T286 1746-1750 Protein denotes RelA
T285 1739-1742 Protein denotes p65
T284 1731-1737 Protein denotes NF-κB1
T283 1723-1727 Protein denotes p105
T282 1715-1721 Protein denotes NF-κB2
T281 1707-1711 Protein denotes p100
R220 T302 T308 causeOf p105,regulate
R221 T304 T308 causeOf p65,regulate
R222 T307 T308 causeOf c-Rel,regulate
R223 T309 T308 themeOf expression,regulate
R224 T310 T309 themeOf TNF,expression
R225 T311 T309 themeOf IL-6,expression
R226 T312 T309 themeOf cyclo-oxygenase-2,expression
R227 T313 T309 themeOf inducible nitric oxide synthase,expression
R228 T316 T315 equivalentTo RANKL,receptor activator of NF-κB ligand
R1282 T1714 T1713 equivalentTo RANK,receptor activator of NF-κB
R1283 T1715 T1714 themeOf RANK,RANK
R1284 T1716 T1718 themeOf CD40,expressed
R1285 T1717 T1718 themeOf TNF receptor family member,expressed
R1286 T1721 T1723 themeOf CD40 ligand,expressed
R1287 T1721 T1720 themeOf CD40 ligand,Binding
R1288 T1722 T1721 equivalentTo CD154,CD40 ligand
R1289 T1727 T1726 themeOf expression,Enhanced
R1290 T1728 T1727 themeOf B-cell activating factor,expression
R1291 T1729 T1728 equivalentTo BAFF,B-cell activating factor
R1292 T1733 T1736 themeOf High mobility group box chromosomal protein 1,released
R1293 T1733 T1735 themeOf High mobility group box chromosomal protein 1,chromatin component
R1294 T1734 T1735 themeOf HMGB1,chromatin component
R1295 T1734 T1733 equivalentTo HMGB1,High mobility group box chromosomal protein 1
R1296 T1735 T1736 themeOf chromatin component,released
R2841 T4096 T4095 themeOf translocation,prevent
R2842 T4105 T4104 themeOf IκBξ,inhibitors
R2843 T4106 T4104 themeOf Bcl-3,inhibitors
R2844 T4114 T4113 themeOf phosphorylation,mediates
R2845 T4121 T4120 equivalentTo NEMO,NF-κB essential modulator
R2846 T4129 T4128 themeOf TNF receptor-1-associated death domain,recruitment
R2847 T4130 T4129 equivalentTo TRADD,TNF receptor-1-associated death domain
R2848 T4131 T4129 equivalentTo receptor interacting protein 1,TNF receptor-1-associated death domain
R2849 T4131 T4135 themeOf receptor interacting protein 1,bind
R2850 T4131 T4128 themeOf receptor interacting protein 1,recruitment
R2851 T4132 T4129 equivalentTo RIP1,TNF receptor-1-associated death domain
R2852 T4132 T4131 equivalentTo RIP1,receptor interacting protein 1
R2853 T4133 T4131 equivalentTo TNF receptor-associated factor (TRAF) 2,receptor interacting protein 1
R2854 T4134 T4135 themeOf TRAF5,bind
R2855 T4134 T4128 themeOf TRAF5,recruitment
R2856 T4136 T4135 themeOf cellular inhibitor of apoptosis (cIAP) 1,bind
R2857 T4137 T4135 themeOf cIAP2,bind
R2858 T4140 T4139 themeOf RIP1,bound
R2859 T4148 T4147 themeOf TAK1,recruit
R2860 T4150 T4149 themeOf NEMO,binding
R2861 T4151 T4149 themeOf TAB1,binding
R2862 T4151 T4147 themeOf TAB1,recruit
R2863 T4152 T4149 themeOf 2,binding
R2864 T4156 T4157 causeOf TLR4,induces
R2865 T4158 T4157 themeOf recruitment,induces
R2866 T4159 T4158 themeOf Toll/IL-1 receptor adaptor protein,recruitment
R2867 T4160 T4158 themeOf Mal,recruitment
R2868 T4161 T4158 themeOf TRIF-related adaptor molecule,recruitment
R2869 T4162 T4159 equivalentTo TRAM,Toll/IL-1 receptor adaptor protein
R2870 T4162 T4161 equivalentTo TRAM,TRIF-related adaptor molecule
R2871 T4164 T4163 equivalentTo MyD88,myeloid differentiation primary response gene 88
R2872 T4165 T4158 themeOf TIR domain-containing adaptor-inducing IFNβ,recruitment
R2873 T4166 T4165 equivalentTo TRIF,TIR domain-containing adaptor-inducing IFNβ
R2874 T4166 T4163 equivalentTo TRIF,myeloid differentiation primary response gene 88
R2875 T4170 T4174 themeOf TRIF,interaction
R2876 T4170 T4171 themeOf TRIF,recruits
R2877 T4172 T4174 themeOf TRAF6,interaction
R2878 T4172 T4171 themeOf TRAF6,recruits
R2879 T4173 T4174 themeOf RIP1,interaction
R2880 T4173 T4171 themeOf RIP1,recruits
R2881 T4178 T4177 causeOf lymphotoxin β receptor,activated
R2882 T4186 T4188 themeOf IKK1,phosphorylation
R2883 T4186 T4185 causeOf IKK1,dependent
R2884 T4186 T4187 themeOf IKK1,activated
R2885 T4189 T4187 causeOf NF-κB inducing kinase,activated
R2886 T4189 T4188 causeOf NF-κB inducing kinase,phosphorylation
R2887 T4190 T4189 equivalentTo NIK,NF-κB inducing kinase
R2888 T4192 T4198 themeOf NIK,degradation
R2889 T4193 T4198 themeOf TRAF2,degradation
R2890 T4194 T4198 themeOf TRAF3,degradation
R2891 T4195 T4198 themeOf cIAP1,degradation
R2892 T4196 T4198 themeOf 2,degradation
R2893 T4197 T4198 themeOf NIK,degradation
R2894 T4204 T4205 themeOf TRAF3,degradation
R2895 T4205 T4203 themeOf degradation,essential
R2896 T4206 T4207 themeOf NIK,degradation
R2897 T4208 T4210 themeOf NIK,phosphorylation
R2898 T4209 T4210 themeOf IKK1,phosphorylation
R2899 T4215 T4214 themeOf CD40,binding
R2900 T4215 T4217 themeOf CD40,interact
R2901 T4218 T4214 themeOf TRAF1,binding
R2902 T4218 T4217 themeOf TRAF1,interact
R2903 T4219 T4217 themeOf TRAF2,interact
R2904 T4219 T4214 themeOf TRAF2,binding
R2905 T4220 T4217 themeOf TRAF3,interact
R2906 T4220 T4214 themeOf TRAF3,binding
R2907 T4221 T4214 themeOf TRAF5,binding
R2908 T4221 T4217 themeOf TRAF5,interact
R2909 T4222 T4214 themeOf TRAF6,binding
R2910 T4222 T4217 themeOf TRAF6,interact
R2911 T4226 T4227 causeOf TRAF6,required
R2912 T4229 T4230 themeOf IL-6,production
R2913 T4231 T4232 causeOf TRAF2,required
R5571 T8365 T8366 themeOf IKK1,deficient
R5572 T8368 T8367 themeOf IKK1,expressing
R5573 T8370 T8373 themeOf IKK2,degradation
R5574 T8370 T8371 themeOf IKK2,activation
R5575 T8371 T8369 themeOf activation,enhanced
R5576 T8372 T8373 themeOf IκBα,degradation
R5577 T8373 T8369 themeOf degradation,enhanced
R6359 T9566 T9571 themeOf RIP1,interactions
R6360 T9567 T9571 themeOf RIP2,interactions
R6361 T9568 T9571 themeOf TRAF6,interactions
R6362 T9569 T9571 themeOf MALT1,interactions
R6363 T9571 T9570 themeOf interactions,disrupts
R6364 T9580 T9579 themeOf A20,association
R6365 T9587 T9588 themeOf A20,deficient
R6366 T9591 T9590 themeOf A20,lacking
R6367 T9595 T9594 themeOf A20,lacking
R6368 T9597 T9598 themeOf A20,expression
R6369 T9598 T9599 themeOf expression,regulated
R6370 T9604 T9603 themeOf TNF,decreased
R6371 T9605 T9603 themeOf IL-1β,decreased
R6372 T9606 T9603 themeOf IL-6,decreased
R6373 T9607 T9603 themeOf RANKL,decreased
R6374 T9608 T9603 themeOf monocyte chemo-attractant protein 1,decreased
R6375 T9613 T9612 themeOf TNF,decreased
R6376 T9614 T9612 themeOf IL-1β,decreased
R8316 T12596 T12602 themeOf ABIN-1,expressed
R8317 T12597 T12602 themeOf ABIN-2,expressed
R8318 T12598 T12602 themeOf ABIN-3,expressed
R8319 T12599 T12602 themeOf TNIP-1,expressed
R8320 T12600 T12602 themeOf TNIP-2,expressed
R8321 T12601 T12602 themeOf TNIP-3,expressed
R8322 T12603 T12602 themeOf A20,expressed
R8323 T12607 T12606 themeOf A20,target
R8324 T12608 T12611 themeOf A20,expression
R8325 T12609 T12611 themeOf ABIN-1,expression
R8326 T12610 T12611 themeOf ABIN-3,expression
R8327 T12613 T12614 themeOf ABIN-1,deficient
R8328 T12613 T12616 themeOf ABIN-1,deficient
R8329 T12615 T12616 themeOf ABIN-2,deficient
R8330 T12618 T12620 themeOf ABIN-3,truncated and inactive form
R8331 T12618 T12619 themeOf ABIN-3,expressed
R8332 T12619 T12620 themeOf expressed,truncated and inactive form
R8333 T12625 T12626 themeOf ABIN-1,deficient
R8334 T12630 T12633 themeOf induced,role
R8335 T12634 T12633 causeOf ABIN-1,role
R8336 T12637 T12636 themeOf ABIN-3,expression
R8337 T12638 T12636 themeOf A20,expression
R9301 T14101 T14100 equivalentTo CYLD,Cylindromatosis
R9302 T14103 T14105 themeOf CYLD,RANK
R9303 T14103 T14104 themeOf CYLD,deubiquitinating enzyme
R9304 T14104 T14105 themeOf deubiquitinating enzyme,RANK
R9305 T14115 T14116 themeOf A20,expressed
R9306 T14118 T14119 themeOf CYLD,RANK
R9307 T14123 T14124 causeOf RANKL,induced
R9308 T14126 T14125 themeOf TRAF6,recruited
R9309 T14130 T14129 themeOf p62,binding
R9310 T14131 T14127 causeOf sequestosome 1,via
R9311 T14132 T14133 causeOf CYLD,mediated
R10167 T15461 T15466 themeOf Single-immunoglobulin IL-1 receptor-related,interaction
R10168 T15462 T15461 equivalentTo SIGIRR,Single-immunoglobulin IL-1 receptor-related
R10169 T15463 T15466 themeOf TIR-8,interaction
R10170 T15463 T15461 equivalentTo TIR-8,Single-immunoglobulin IL-1 receptor-related
R10171 T15465 T15466 themeOf IL-1R,interaction
R10172 T15467 T15466 themeOf MyD88,interaction
R10173 T15468 T15466 themeOf IRAK1,interaction
R10174 T15469 T15466 themeOf TRAF6,interaction
R10175 T15472 T15473 themeOf SIGIRR,expressed
R10176 T15476 T15477 themeOf SIGIRR,deficient
R10177 T15479 T15478 themeOf SIGIRR,expression
R10178 T15479 T15480 themeOf SIGIRR,expression
R10759 T16339 T16341 themeOf Expression,inducible
R10760 T16340 T16339 themeOf TRAF1,Expression
R10761 T16342 T16341 causeOf TNF,inducible
R10762 T16343 T16341 causeOf overexpression,inducible
R10763 T16344 T16343 themeOf TRAF1,overexpression
R10764 T16346 T16347 themeOf TRAF1,deficient
R10765 T16351 T16352 themeOf TRAF1,deficient
R10766 T16355 T16356 themeOf TRAF1,binding
R10767 T16362 T16361 themeOf TRAF1,association
R11392 T17409 T17410 themeOf IL-17,producing
R11393 T17413 T17414 causeOf miR-155,promote
R11394 T17415 T17416 themeOf TNF,production
R11395 T17416 T17414 themeOf production,promote
R11396 T17426 T17425 themeOf secretion,increased
R11397 T17427 T17426 themeOf matrix metalloproteinase-1,secretion
R11398 T17428 T17426 themeOf IL-6,secretion
R11399 T17429 T17432 themeOf miR-16,expression
R11400 T17430 T17432 themeOf miR-132,expression
R11401 T17431 T17432 themeOf miR-223,expression
R12799 T19388 T19393 causeOf engagement,trigger
R12800 T19389 T19388 themeOf TNFR1,engagement
R12801 T19390 T19388 themeOf CD40,engagement
R12802 T19391 T19388 themeOf RANK,engagement
R12803 T19392 T19393 causeOf TLR4,trigger
R12804 T19392 T19388 themeOf TLR4,engagement
R12805 T19394 T19393 themeOf recruitment,trigger
R12806 T19396 T19395 equivalentTo TRADD,TNF receptor 1-associated death domain protein
R12807 T19398 T19394 themeOf MAL,recruitment
R12808 T19399 T19394 themeOf TIR domain-containing adaptor-inducing IFNβ,recruitment
R12809 T19400 T19399 equivalentTo TRIF,TIR domain-containing adaptor-inducing IFNβ
R12810 T19401 T19399 equivalentTo RIP1,TIR domain-containing adaptor-inducing IFNβ
R12811 T19404 T19403 equivalentTo TRAF2,IRAK4
R12812 T19404 T19399 equivalentTo TRAF2,TIR domain-containing adaptor-inducing IFNβ
R12813 T19405 T19394 themeOf TRAF6,recruitment
R12814 T19406 T19394 themeOf cIAP1,recruitment
R12815 T19407 T19394 themeOf cIAP2,recruitment
R12816 T19408 T19412 themeOf RIP1,recruitment
R12817 T19409 T19412 themeOf IRAK1,recruitment
R12818 T19410 T19412 themeOf NEMO,recruitment
R12819 T19412 T19411 themeOf recruitment,resulting
R12820 T19413 T19412 themeOf IKK2,recruitment
R12821 T19414 T19412 themeOf TAK1,recruitment
R12822 T19418 T19417 themeOf IκBα,phosphorylates
R12823 T19420 T19422 themeOf p65,translocate
R12824 T19421 T19422 themeOf p50,translocate
R12825 T19423 T19422 locationOf nucleus,translocate
R12826 T19425 T19429 themeOf A20,recruited
R12827 T19426 T19429 themeOf CYLD,recruited
R12828 T19427 T19430 themeOf RIP1,binding
R12829 T19427 T19429 themeOf RIP1,recruited
R12830 T19428 T19429 themeOf TRAF6,recruited
R12831 T19428 T19430 themeOf TRAF6,binding
R12832 T19431 T19429 themeOf ABIN-1,recruited
R12833 T19432 T19429 themeOf p62,recruited
R12834 T19432 T19430 themeOf p62,binding
R12835 T19434 T19433 themeOf expression,inhibiting
R12836 T19435 T19434 themeOf IRAK1,expression
R12837 T19436 T19434 themeOf TRAF6,expression
R12838 T19440 T19441 themeOf TLR4,binding
R12839 T19441 T19439 themeOf binding,compete
R12840 T19442 T19441 themeOf IRAK1,binding
R12841 T19443 T19441 themeOf TRAF6,binding
R12842 T19457 T19452 themeOf single-immunoglobulinIL-1 receptor-related,RANK
R13918 T21362 T21361 equivalentTo NIK,NF-κB inducing kinase
R13919 T21369 T21368 themeOf NIK,degradation
R13920 T21372 T21371 themeOf TRAF3,binding
R13921 T21372 T21373 themeOf TRAF3,recruited
R13922 T21381 T21382 themeOf TRAF3,degraded
R13923 T21385 T21386 causeOf NIK,activates
R13924 T21385 T21388 causeOf NIK,mediates
R13925 T21387 T21386 themeOf IKK1,activates
R13926 T21387 T21388 causeOf IKK1,mediates
R13927 T21389 T21390 themeOf p100,phosphorylation
R13928 T21390 T21388 themeOf phosphorylation,mediates
R13929 T21392 T21391 themeOf p100,degradation
R13930 T21393 T21391 themeOf p52,degradation
R13931 T21394 T21391 themeOf RelB,degradation