
PMC:3218875
Annnotations
testone
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T21324 | 14740-14751 | Protein_catabolism | denotes | degradation |
T21323 | 14649-14664 | Phosphorylation | denotes | phosphorylation |
T21322 | 14629-14637 | Positive_regulation | denotes | mediates |
T21321 | 14588-14602 | Phosphorylation | denotes | phosphorylates |
T21320 | 14545-14554 | Positive_regulation | denotes | increased |
T21319 | 14253-14262 | Binding | denotes | recruited |
T21318 | 14179-14190 | Protein_catabolism | denotes | degradation |
T21317 | 13987-13997 | Gene_expression | denotes | expression |
T21316 | 15143-15165 | Protein | denotes | tumour necrosis factor |
T21315 | 15138-15141 | Protein | denotes | TNF |
T21314 | 15071-15098 | Protein | denotes | receptor activator of NF-κB |
T21313 | 15065-15069 | Protein | denotes | RANK |
T21312 | 14846-14851 | Protein | denotes | TRAF1 |
T21311 | 14839-14844 | Protein | denotes | TRAF3 |
T21310 | 14799-14803 | Protein | denotes | RelB |
T21309 | 14763-14766 | Protein | denotes | p52 |
T21308 | 14755-14759 | Protein | denotes | p100 |
T21307 | 14644-14648 | Protein | denotes | p100 |
T21306 | 14617-14621 | Protein | denotes | IKK1 |
T21305 | 14579-14582 | Protein | denotes | NIK |
T21304 | 14555-14558 | Protein | denotes | NIK |
T21303 | 14513-14516 | Protein | denotes | NIK |
T21302 | 14491-14496 | Protein | denotes | TRAF3 |
T21301 | 14473-14476 | Protein | denotes | NIK |
T21300 | 14454-14459 | Protein | denotes | TRAF3 |
T21299 | 14407-14408 | Protein | denotes | 2 |
T21298 | 14401-14406 | Protein | denotes | cIAP1 |
T21297 | 14354-14355 | Protein | denotes | 2 |
T21296 | 14348-14353 | Protein | denotes | cIAP1 |
T21295 | 14286-14291 | Protein | denotes | TRAF2 |
T21294 | 14244-14249 | Protein | denotes | TRAF3 |
T21293 | 14207-14210 | Protein | denotes | NIK |
T21292 | 14194-14197 | Protein | denotes | NIK |
T21291 | 14108-14109 | Protein | denotes | 2 |
T21290 | 14102-14107 | Protein | denotes | cIAP1 |
T21289 | 14092-14097 | Protein | denotes | TRAF3 |
T21288 | 14085-14090 | Protein | denotes | TRAF2 |
T21287 | 14028-14031 | Protein | denotes | NIK |
T21286 | 13982-13985 | Protein | denotes | NIK |
T21285 | 13959-13980 | Protein | denotes | NF-κB inducing kinase |
T21284 | 13889-13893 | Protein | denotes | RANK |
T21283 | 13880-13884 | Protein | denotes | CD40 |
T19331 | 10316-10325 | Negative_regulation | denotes | inhibitor |
T19330 | 10010-10017 | Binding | denotes | binding |
T19329 | 9988-9995 | Negative_regulation | denotes | compete |
T19328 | 9914-9923 | Negative_regulation | denotes | inhibited |
T19327 | 9847-9857 | Gene_expression | denotes | expression |
T19326 | 9836-9846 | Negative_regulation | denotes | inhibiting |
T19325 | 9727-9734 | Binding | denotes | binding |
T19324 | 9692-9701 | Binding | denotes | recruited |
T19323 | 9356-9363 | Entity | denotes | nucleus |
T19322 | 9337-9348 | Localization | denotes | translocate |
T19321 | 9258-9269 | Protein_catabolism | denotes | degradation |
T19320 | 9180-9194 | Phosphorylation | denotes | phosphorylates |
T19319 | 8829-8837 | Positive_regulation | denotes | inducing |
T19318 | 8689-8700 | Binding | denotes | recruitment |
T19317 | 8677-8684 | Positive_regulation | denotes | trigger |
T19316 | 8599-8609 | Binding | denotes | engagement |
T19315 | 10701-10723 | Protein | denotes | tumour necrosis factor |
T19314 | 10696-10699 | Protein | denotes | TNF |
T19313 | 10558-10600 | Protein | denotes | single-immunoglobulinIL-1 receptor-related |
T19312 | 10550-10556 | Protein | denotes | SIGIRR |
T19311 | 10518-10548 | Protein | denotes | receptor interacting protein 1 |
T19310 | 10512-10516 | Protein | denotes | RIP1 |
T19309 | 10483-10510 | Protein | denotes | receptor activator of NF-κB |
T19308 | 10477-10481 | Protein | denotes | RANK |
T19307 | 10430-10455 | Protein | denotes | NF-κB essential modulator |
T19306 | 10424-10428 | Protein | denotes | NEMO |
T19305 | 10374-10422 | Protein | denotes | myeloid differentiation primary response gene 88 |
T19304 | 10367-10372 | Protein | denotes | MyD88 |
T19303 | 10277-10292 | Protein | denotes | cylindromatosis |
T19302 | 10271-10275 | Protein | denotes | CYLD |
T19301 | 10200-10230 | Protein | denotes | A20-binding inhibitor of NF-κB |
T19300 | 10194-10198 | Protein | denotes | ABIN |
T19299 | 10031-10036 | Protein | denotes | TRAF6 |
T19298 | 10021-10026 | Protein | denotes | IRAK1 |
T19297 | 10001-10005 | Protein | denotes | TLR4 |
T19296 | 9953-9959 | Protein | denotes | SIGIRR |
T19295 | 9871-9876 | Protein | denotes | TRAF6 |
T19294 | 9861-9866 | Protein | denotes | IRAK1 |
T19293 | 9771-9774 | Protein | denotes | p62 |
T19292 | 9760-9766 | Protein | denotes | ABIN-1 |
T19291 | 9667-9672 | Protein | denotes | TRAF6 |
T19290 | 9658-9662 | Protein | denotes | RIP1 |
T19289 | 9542-9546 | Protein | denotes | CYLD |
T19288 | 9534-9537 | Protein | denotes | A20 |
T19287 | 9400-9405 | Protein | denotes | TRAF1 |
T19286 | 9329-9332 | Protein | denotes | p50 |
T19285 | 9321-9324 | Protein | denotes | p65 |
T19284 | 9195-9199 | Protein | denotes | IκBα |
T19283 | 9160-9164 | Protein | denotes | IKK2 |
T19282 | 9121-9125 | Protein | denotes | TAK1 |
T19281 | 9115-9119 | Protein | denotes | TAK1 |
T19280 | 9106-9110 | Protein | denotes | IKK2 |
T19279 | 9023-9027 | Protein | denotes | NEMO |
T19278 | 8999-9004 | Protein | denotes | IRAK1 |
T19277 | 8990-8994 | Protein | denotes | RIP1 |
T19276 | 8926-8931 | Protein | denotes | cIAP2 |
T19275 | 8919-8924 | Protein | denotes | cIAP1 |
T19274 | 8912-8917 | Protein | denotes | TRAF6 |
T19273 | 8905-8910 | Protein | denotes | TRAF2 |
T19272 | 8874-8879 | Protein | denotes | IRAK4 |
T19271 | 8867-8872 | Protein | denotes | IRAK1 |
T19270 | 8861-8865 | Protein | denotes | RIP1 |
T19269 | 8844-8848 | Protein | denotes | TRIF |
T19268 | 8799-8842 | Protein | denotes | TIR domain-containing adaptor-inducing IFNβ |
T19267 | 8794-8797 | Protein | denotes | MAL |
T19266 | 8787-8792 | Protein | denotes | MyD88 |
T19265 | 8779-8784 | Protein | denotes | TRADD |
T19264 | 8731-8777 | Protein | denotes | TNF receptor 1-associated death domain protein |
T19263 | 8672-8676 | Protein | denotes | TLR4 |
T19262 | 8662-8666 | Protein | denotes | RANK |
T19261 | 8656-8660 | Protein | denotes | CD40 |
T19260 | 8649-8654 | Protein | denotes | TNFR1 |
T17361 | 32702-32712 | Gene_expression | denotes | expression |
T17360 | 32531-32540 | Localization | denotes | secretion |
T17359 | 32521-32530 | Positive_regulation | denotes | increased |
T17358 | 32481-32489 | Positive_regulation | denotes | elevated |
T17357 | 32341-32350 | Regulation | denotes | regulator |
T17356 | 31934-31944 | Gene_expression | denotes | expression |
T17355 | 31684-31694 | Gene_expression | denotes | production |
T17354 | 31672-31679 | Positive_regulation | denotes | promote |
T17353 | 31509-31516 | Negative_regulation | denotes | prevent |
T17352 | 31458-31472 | Positive_regulation | denotes | overexpression |
T17351 | 31269-31278 | Gene_expression | denotes | producing |
T17350 | 31237-31250 | Gene_expression | denotes | overexpressed |
T17349 | 31067-31076 | Gene_expression | denotes | expressed |
T17348 | 30952-30958 | Binding | denotes | target |
T17347 | 30689-30696 | Positive_regulation | denotes | induced |
T17346 | 30444-30448 | Binding | denotes | bind |
T17345 | 32659-32666 | Protein | denotes | miR-223 |
T17344 | 32646-32653 | Protein | denotes | miR-132 |
T17343 | 32638-32644 | Protein | denotes | miR-16 |
T17342 | 32575-32579 | Protein | denotes | IL-6 |
T17341 | 32544-32570 | Protein | denotes | matrix metalloproteinase-1 |
T17340 | 32500-32507 | Protein | denotes | miR-203 |
T17339 | 32368-32402 | Protein | denotes | monocyte chemoattractant protein 1 |
T17338 | 32324-32332 | Protein | denotes | miR-124a |
T17337 | 32152-32159 | Protein | denotes | miR-155 |
T17336 | 31754-31761 | Protein | denotes | miR-155 |
T17335 | 31680-31683 | Protein | denotes | TNF |
T17334 | 31651-31658 | Protein | denotes | miR-155 |
T17333 | 31450-31457 | Protein | denotes | miR-155 |
T17332 | 31364-31372 | Protein | denotes | miR-146a |
T17331 | 31263-31268 | Protein | denotes | IL-17 |
T17330 | 31254-31257 | Protein | denotes | CD4 |
T17329 | 31220-31228 | Protein | denotes | miR-146a |
T17328 | 31055-31062 | Protein | denotes | miR-155 |
T17327 | 31015-31019 | Protein | denotes | RIP1 |
T17326 | 31006-31010 | Protein | denotes | IKKε |
T17325 | 30931-30938 | Protein | denotes | miR-155 |
T17324 | 30894-30902 | Protein | denotes | miR-146a |
T17323 | 30853-30858 | Protein | denotes | TRAF6 |
T17322 | 30843-30848 | Protein | denotes | IRAK1 |
T17321 | 30771-30779 | Protein | denotes | miR-146a |
T17320 | 30736-30739 | Protein | denotes | TNF |
T17319 | 30729-30734 | Protein | denotes | IL-1β |
T17318 | 30590-30597 | Protein | denotes | miR-155 |
T17317 | 30584-30585 | Protein | denotes | b |
T17316 | 30575-30583 | Protein | denotes | miR-146a |
T16314 | 29761-29769 | Binding | denotes | interact |
T16313 | 29720-29727 | Binding | denotes | recruit |
T16312 | 29639-29646 | Binding | denotes | binding |
T16311 | 29336-29345 | Negative_regulation | denotes | deficient |
T16310 | 29128-29137 | Negative_regulation | denotes | deficient |
T16309 | 29110-29120 | Positive_regulation | denotes | activation |
T16308 | 29059-29073 | Positive_regulation | denotes | overexpression |
T16307 | 29038-29047 | Positive_regulation | denotes | inducible |
T16306 | 29015-29025 | Gene_expression | denotes | Expression |
T16305 | 30190-30195 | Protein | denotes | TRAF1 |
T16304 | 30057-30062 | Protein | denotes | TRAF1 |
T16303 | 29955-29960 | Protein | denotes | TRAF1 |
T16302 | 29728-29731 | Protein | denotes | A20 |
T16301 | 29708-29713 | Protein | denotes | TRAF1 |
T16300 | 29595-29600 | Protein | denotes | TRAF1 |
T16299 | 29528-29533 | Protein | denotes | TRAF1 |
T16298 | 29426-29431 | Protein | denotes | TRAF2 |
T16297 | 29330-29335 | Protein | denotes | TRAF1 |
T16296 | 29299-29303 | Protein | denotes | CD40 |
T16295 | 29251-29256 | Protein | denotes | TRAF1 |
T16294 | 29170-29173 | Protein | denotes | TNF |
T16293 | 29122-29127 | Protein | denotes | TRAF1 |
T16292 | 29092-29095 | Protein | denotes | TNF |
T16291 | 29077-29082 | Protein | denotes | TRAF1 |
T16290 | 29051-29054 | Protein | denotes | TNF |
T16289 | 29029-29034 | Protein | denotes | TRAF1 |
T16288 | 28862-28867 | Protein | denotes | TRAF1 |
T16287 | 28798-28807 | Protein | denotes | ubiquitin |
T16286 | 28688-28693 | Protein | denotes | TRAF1 |
T16285 | 28655-28687 | Protein | denotes | TNF receptor-associated factor 1 |
T15442 | 28574-28584 | Gene_expression | denotes | expression |
T15441 | 28436-28446 | Gene_expression | denotes | expression |
T15440 | 28391-28401 | Gene_expression | denotes | expression |
T15439 | 28219-28228 | Negative_regulation | denotes | deficient |
T15438 | 27898-27907 | Gene_expression | denotes | expressed |
T15437 | 27616-27627 | Binding | denotes | interaction |
T15436 | 27553-27562 | Negative_regulation | denotes | inhibitor |
T15435 | 28594-28600 | Protein | denotes | SIGIRR |
T15434 | 28510-28516 | Protein | denotes | SIGIRR |
T15433 | 28405-28411 | Protein | denotes | SIGIRR |
T15432 | 28212-28218 | Protein | denotes | SIGIRR |
T15431 | 28168-28174 | Protein | denotes | SIGIRR |
T15430 | 28019-28025 | Protein | denotes | SIGIRR |
T15429 | 27843-27849 | Protein | denotes | SIGIRR |
T15428 | 27813-27819 | Protein | denotes | SIGIRR |
T15427 | 27717-27722 | Protein | denotes | IL-1R |
T15426 | 27666-27671 | Protein | denotes | TRAF6 |
T15425 | 27657-27662 | Protein | denotes | IRAK1 |
T15424 | 27650-27655 | Protein | denotes | MyD88 |
T15423 | 27566-27571 | Protein | denotes | IL-1R |
T15422 | 27464-27469 | Protein | denotes | TIR-8 |
T15421 | 27433-27439 | Protein | denotes | SIGIRR |
T15420 | 27388-27431 | Protein | denotes | Single-immunoglobulin IL-1 receptor-related |
T15419 | 27336-27379 | Protein | denotes | Single-immunoglobulin IL-1 receptor-related |
T14064 | 26763-26766 | Positive_regulation | denotes | via |
T14063 | 26730-26739 | Binding | denotes | recruited |
T14062 | 26696-26703 | Positive_regulation | denotes | induced |
T14061 | 26635-26645 | Gene_expression | denotes | expression |
T14060 | 26593-26600 | Gene_expression | denotes | produce |
T14059 | 25997-26006 | Gene_expression | denotes | expressed |
T14058 | 27244-27248 | Protein | denotes | CYLD |
T14057 | 27135-27139 | Protein | denotes | RANK |
T14056 | 27106-27110 | Protein | denotes | CYLD |
T14055 | 26993-26996 | Protein | denotes | p62 |
T14054 | 26896-26901 | Protein | denotes | TRAF6 |
T14053 | 26862-26866 | Protein | denotes | CYLD |
T14052 | 26824-26838 | Protein | denotes | sequestosome 1 |
T14051 | 26805-26808 | Protein | denotes | p62 |
T14050 | 26771-26780 | Protein | denotes | ubiquitin |
T14049 | 26757-26762 | Protein | denotes | TRAF6 |
T14048 | 26690-26695 | Protein | denotes | RANKL |
T14047 | 26630-26634 | Protein | denotes | CYLD |
T14046 | 26559-26564 | Protein | denotes | RANKL |
T14045 | 26420-26424 | Protein | denotes | CYLD |
T14044 | 26333-26337 | Protein | denotes | RANK |
T14043 | 26290-26294 | Protein | denotes | CYLD |
T14042 | 26143-26147 | Protein | denotes | CYLD |
T14041 | 25985-25988 | Protein | denotes | A20 |
T14040 | 25948-25952 | Protein | denotes | CYLD |
T14039 | 25933-25936 | Protein | denotes | A20 |
T14038 | 25884-25887 | Protein | denotes | A20 |
T14037 | 25843-25847 | Protein | denotes | TAK1 |
T14036 | 25834-25838 | Protein | denotes | RIP1 |
T14035 | 25827-25832 | Protein | denotes | TRAF7 |
T14034 | 25820-25825 | Protein | denotes | TRAF6 |
T14033 | 25813-25818 | Protein | denotes | TRAF2 |
T14032 | 25807-25811 | Protein | denotes | NEMO |
T14031 | 25674-25678 | Protein | denotes | RANK |
T14030 | 25588-25611 | Protein | denotes | deubiquitinating enzyme |
T14029 | 25578-25582 | Protein | denotes | CYLD |
T14028 | 25385-25389 | Protein | denotes | CYLD |
T14027 | 25279-25283 | Protein | denotes | CYLD |
T14026 | 25262-25277 | Protein | denotes | Cylindromatosis |
T14025 | 25238-25253 | Protein | denotes | Cylindromatosis |
T12563 | 24568-24574 | Regulation | denotes | effect |
T12562 | 24482-24492 | Gene_expression | denotes | expression |
T12561 | 24208-24212 | Regulation | denotes | role |
T12560 | 24143-24147 | Transcription | denotes | mRNA |
T12559 | 24121-24125 | Positive_regulation | denotes | high |
T12558 | 24080-24087 | Positive_regulation | denotes | induced |
T12557 | 23922-23931 | Negative_regulation | denotes | deficient |
T12556 | 23874-23882 | Negative_regulation | denotes | inhibits |
T12555 | 23790-23797 | Negative_regulation | denotes | lacking |
T12554 | 23752-23759 | Gene_expression | denotes | express |
T12553 | 23717-23726 | Gene_expression | denotes | expressed |
T12552 | 23523-23532 | Negative_regulation | denotes | deficient |
T12551 | 23502-23511 | Negative_regulation | denotes | deficient |
T12550 | 23370-23374 | Regulation | denotes | role |
T12549 | 23315-23325 | Gene_expression | denotes | expression |
T12548 | 23229-23235 | Binding | denotes | target |
T12547 | 23128-23142 | Positive_regulation | denotes | overexpression |
T12546 | 23066-23076 | Positive_regulation | denotes | activation |
T12545 | 23052-23059 | Negative_regulation | denotes | inhibit |
T12544 | 22999-23008 | Gene_expression | denotes | expressed |
T12543 | 24679-24685 | Protein | denotes | ABIN-1 |
T12542 | 24537-24540 | Protein | denotes | A20 |
T12541 | 24526-24532 | Protein | denotes | ABIN-3 |
T12540 | 24239-24242 | Protein | denotes | A20 |
T12539 | 24217-24223 | Protein | denotes | ABIN-1 |
T12538 | 24136-24142 | Protein | denotes | ABIN-1 |
T12537 | 24076-24079 | Protein | denotes | TNF |
T12536 | 24048-24054 | Protein | denotes | ABIN-1 |
T12535 | 23962-23965 | Protein | denotes | TNF |
T12534 | 23915-23921 | Protein | denotes | ABIN-1 |
T12533 | 23883-23886 | Protein | denotes | TNF |
T12532 | 23853-23859 | Protein | denotes | ABIN-1 |
T12531 | 23848-23851 | Protein | denotes | A20 |
T12530 | 23762-23789 | Protein | denotes | truncated and inactive form |
T12529 | 23707-23713 | Protein | denotes | ABIN-3 |
T12528 | 23516-23522 | Protein | denotes | ABIN-2 |
T12527 | 23495-23501 | Protein | denotes | ABIN-1 |
T12526 | 23383-23386 | Protein | denotes | A20 |
T12525 | 23308-23314 | Protein | denotes | ABIN-3 |
T12524 | 23297-23303 | Protein | denotes | ABIN-1 |
T12523 | 23292-23295 | Protein | denotes | A20 |
T12522 | 23236-23239 | Protein | denotes | A20 |
T12521 | 23080-23083 | Protein | denotes | TNF |
T12520 | 23009-23012 | Protein | denotes | A20 |
T12519 | 22959-22965 | Protein | denotes | TNIP-3 |
T12518 | 22947-22953 | Protein | denotes | TNIP-2 |
T12517 | 22939-22945 | Protein | denotes | TNIP-1 |
T12516 | 22917-22923 | Protein | denotes | ABIN-3 |
T12515 | 22906-22912 | Protein | denotes | ABIN-2 |
T12514 | 22898-22904 | Protein | denotes | ABIN-1 |
T12513 | 22866-22869 | Protein | denotes | A20 |
T9496 | 22545-22554 | Negative_regulation | denotes | repressed |
T9495 | 21456-21460 | Negative_regulation | denotes | lack |
T9494 | 20970-20979 | Negative_regulation | denotes | decreased |
T9493 | 20888-20895 | Positive_regulation | denotes | mediate |
T9492 | 20586-20595 | Negative_regulation | denotes | decreased |
T9491 | 20503-20513 | Gene_expression | denotes | expression |
T9490 | 20275-20285 | Gene_expression | denotes | expressing |
T9489 | 20131-20140 | Regulation | denotes | regulated |
T9488 | 20110-20120 | Gene_expression | denotes | expression |
T9487 | 19933-19943 | Gene_expression | denotes | expression |
T9486 | 19790-19797 | Negative_regulation | denotes | lacking |
T9485 | 19475-19482 | Negative_regulation | denotes | lacking |
T9484 | 19315-19324 | Negative_regulation | denotes | deficient |
T9483 | 19130-19139 | Negative_regulation | denotes | deficient |
T9482 | 18850-18859 | Negative_regulation | denotes | inhibitor |
T9481 | 18738-18749 | Binding | denotes | association |
T9480 | 18512-18524 | Binding | denotes | interactions |
T9479 | 18498-18508 | Negative_regulation | denotes | disruption |
T9478 | 18451-18463 | Binding | denotes | interactions |
T9477 | 18417-18425 | Negative_regulation | denotes | disrupts |
T9476 | 22791-22794 | Protein | denotes | A20 |
T9475 | 22555-22558 | Protein | denotes | A20 |
T9474 | 22507-22510 | Protein | denotes | A20 |
T9473 | 22327-22330 | Protein | denotes | A20 |
T9472 | 22246-22249 | Protein | denotes | A20 |
T9471 | 22208-22216 | Protein | denotes | cytokine |
T9470 | 22176-22179 | Protein | denotes | TNF |
T9469 | 22151-22154 | Protein | denotes | TNF |
T9468 | 22116-22119 | Protein | denotes | A20 |
T9467 | 22029-22032 | Protein | denotes | A20 |
T9466 | 21982-21985 | Protein | denotes | A20 |
T9465 | 21828-21831 | Protein | denotes | A20 |
T9464 | 21607-21610 | Protein | denotes | A20 |
T9463 | 21461-21464 | Protein | denotes | A20 |
T9462 | 21257-21260 | Protein | denotes | A20 |
T9461 | 21162-21165 | Protein | denotes | A20 |
T9460 | 21013-21016 | Protein | denotes | A20 |
T9459 | 21004-21009 | Protein | denotes | IL-1β |
T9458 | 20996-20999 | Protein | denotes | TNF |
T9457 | 20869-20874 | Protein | denotes | IL-1β |
T9456 | 20861-20864 | Protein | denotes | TNF |
T9455 | 20703-20706 | Protein | denotes | A20 |
T9454 | 20639-20674 | Protein | denotes | monocyte chemo-attractant protein 1 |
T9453 | 20632-20637 | Protein | denotes | RANKL |
T9452 | 20618-20622 | Protein | denotes | IL-6 |
T9451 | 20611-20616 | Protein | denotes | IL-1β |
T9450 | 20606-20609 | Protein | denotes | TNF |
T9449 | 20499-20502 | Protein | denotes | A20 |
T9448 | 20271-20274 | Protein | denotes | A20 |
T9447 | 20168-20171 | Protein | denotes | A20 |
T9446 | 20106-20109 | Protein | denotes | A20 |
T9445 | 19929-19932 | Protein | denotes | A20 |
T9444 | 19798-19801 | Protein | denotes | A20 |
T9443 | 19677-19680 | Protein | denotes | A20 |
T9442 | 19643-19646 | Protein | denotes | TNF |
T9441 | 19483-19486 | Protein | denotes | A20 |
T9440 | 19360-19363 | Protein | denotes | TNF |
T9439 | 19311-19314 | Protein | denotes | A20 |
T9438 | 19126-19129 | Protein | denotes | A20 |
T9437 | 19062-19065 | Protein | denotes | A20 |
T9436 | 18964-18967 | Protein | denotes | A20 |
T9435 | 18882-18904 | Protein | denotes | Tax1-binding protein 1 |
T9434 | 18838-18877 | Protein | denotes | A20-binding inhibitor of NF-κB (ABIN) 1 |
T9433 | 18753-18756 | Protein | denotes | A20 |
T9432 | 18691-18694 | Protein | denotes | A20 |
T9431 | 18634-18635 | Protein | denotes | 2 |
T9430 | 18628-18633 | Protein | denotes | cIAP1 |
T9429 | 18618-18623 | Protein | denotes | TRAF2 |
T9428 | 18611-18616 | Protein | denotes | TRAF6 |
T9427 | 18577-18583 | Protein | denotes | Ubc5hc |
T9426 | 18567-18572 | Protein | denotes | Ubc13 |
T9425 | 18404-18409 | Protein | denotes | MALT1 |
T9424 | 18394-18399 | Protein | denotes | TRAF6 |
T9423 | 18388-18392 | Protein | denotes | RIP2 |
T9422 | 18382-18386 | Protein | denotes | RIP1 |
T9421 | 18275-18278 | Protein | denotes | A20 |
T9420 | 18132-18135 | Protein | denotes | TNF |
T9419 | 18038-18043 | Protein | denotes | NF-κB |
T9418 | 17986-18011 | Protein | denotes | ubiquitin-editing protein |
T9417 | 17972-17979 | Protein | denotes | TNFAIP3 |
T9416 | 17953-17956 | Protein | denotes | A20 |
T9415 | 17941-17944 | Protein | denotes | A20 |
T8347 | 17462-17473 | Protein_catabolism | denotes | degradation |
T8346 | 17428-17436 | Positive_regulation | denotes | enhanced |
T8345 | 17333-17343 | Gene_expression | denotes | expressing |
T8344 | 17302-17311 | Negative_regulation | denotes | deficient |
T8343 | 17781-17785 | Protein | denotes | IKK1 |
T8342 | 17680-17683 | Protein | denotes | NIK |
T8341 | 17660-17664 | Protein | denotes | IKK1 |
T8340 | 17596-17601 | Protein | denotes | STAT1 |
T8339 | 17480-17484 | Protein | denotes | IKK1 |
T8338 | 17457-17461 | Protein | denotes | IκBα |
T8337 | 17437-17441 | Protein | denotes | IKK2 |
T8336 | 17353-17357 | Protein | denotes | IKK1 |
T8335 | 17297-17301 | Protein | denotes | IKK1 |
T8334 | 17069-17073 | Protein | denotes | IKK1 |
T8333 | 16915-16921 | Protein | denotes | TOLLIP |
T8332 | 16903-16909 | Protein | denotes | IRAK-M |
T8331 | 16895-16901 | Protein | denotes | MyD88s |
T3983 | 15785-15795 | Gene_expression | denotes | production |
T3982 | 15752-15760 | Positive_regulation | denotes | mediated |
T3981 | 15734-15742 | Positive_regulation | denotes | required |
T3980 | 15469-15480 | Protein_catabolism | denotes | proteolysis |
T3979 | 15456-15461 | Positive_regulation | denotes | leads |
T3978 | 15362-15370 | Binding | denotes | interact |
T3977 | 15323-15330 | Binding | denotes | binding |
T3976 | 13803-13818 | Phosphorylation | denotes | phosphorylation |
T3975 | 13751-13762 | Protein_catabolism | denotes | degradation |
T3974 | 13678-13689 | Protein_catabolism | denotes | degradation |
T3973 | 13457-13468 | Protein_catabolism | denotes | degradation |
T3972 | 13227-13241 | Protein_modification | denotes | -translational |
T3971 | 13206-13215 | Regulation | denotes | regulated |
T3970 | 13137-13152 | Phosphorylation | denotes | phosphorylation |
T3969 | 12588-12596 | Positive_regulation | denotes | activate |
T3968 | 12556-12567 | Binding | denotes | interaction |
T3967 | 12509-12517 | Binding | denotes | recruits |
T3966 | 12465-12483 | Negative_regulation | denotes | selfubiquitination |
T3965 | 12311-12319 | Positive_regulation | denotes | inducing |
T3964 | 12045-12056 | Binding | denotes | recruitment |
T3963 | 12033-12040 | Positive_regulation | denotes | induces |
T3962 | 11498-11505 | Binding | denotes | binding |
T3961 | 11488-11498 | Entity | denotes | ubiquitin- |
T3960 | 11447-11454 | Binding | denotes | recruit |
T3959 | 11197-11202 | Binding | denotes | bound |
T3958 | 11071-11075 | Binding | denotes | bind |
T3957 | 10826-10837 | Binding | denotes | recruitment |
T3956 | 8180-8191 | Protein_catabolism | denotes | degradation |
T3955 | 8092-8107 | Phosphorylation | denotes | phosphorylation |
T3954 | 7344-7354 | Negative_regulation | denotes | inhibitors |
T3953 | 7193-7206 | Localization | denotes | translocation |
T3952 | 7185-7192 | Entity | denotes | nuclear |
T3951 | 7171-7178 | Negative_regulation | denotes | prevent |
T3950 | 15890-15894 | Protein | denotes | CD40 |
T3949 | 15850-15855 | Protein | denotes | TRAF3 |
T3948 | 15803-15808 | Protein | denotes | TRAF2 |
T3947 | 15780-15784 | Protein | denotes | IL-6 |
T3946 | 15747-15751 | Protein | denotes | CD40 |
T3945 | 15725-15730 | Protein | denotes | TRAF6 |
T3944 | 15676-15680 | Protein | denotes | CD40 |
T3943 | 15499-15504 | Protein | denotes | TRAF3 |
T3942 | 15489-15494 | Protein | denotes | TRAF2 |
T3941 | 15440-15445 | Protein | denotes | TRAF6 |
T3940 | 15429-15434 | Protein | denotes | TRAF5 |
T3939 | 15422-15427 | Protein | denotes | TRAF3 |
T3938 | 15415-15420 | Protein | denotes | TRAF2 |
T3937 | 15408-15413 | Protein | denotes | TRAF1 |
T3936 | 15357-15361 | Protein | denotes | RANK |
T3935 | 15348-15352 | Protein | denotes | CD40 |
T3934 | 15228-15232 | Protein | denotes | RANK |
T3933 | 15201-15223 | Protein | denotes | lymphotoxin β receptor |
T3932 | 15195-15199 | Protein | denotes | CD40 |
T3931 | 13798-13802 | Protein | denotes | IKK1 |
T3930 | 13777-13780 | Protein | denotes | NIK |
T3929 | 13725-13728 | Protein | denotes | NIK |
T3928 | 13672-13677 | Protein | denotes | TRAF3 |
T3927 | 13634-13635 | Protein | denotes | 2 |
T3926 | 13628-13633 | Protein | denotes | cIAP1 |
T3925 | 13618-13623 | Protein | denotes | TRAF2 |
T3924 | 13540-13545 | Protein | denotes | TRAF3 |
T3923 | 13426-13429 | Protein | denotes | NIK |
T3922 | 13395-13396 | Protein | denotes | 2 |
T3921 | 13389-13394 | Protein | denotes | cIAP1 |
T3920 | 13378-13383 | Protein | denotes | TRAF3 |
T3919 | 13371-13376 | Protein | denotes | TRAF2 |
T3918 | 13330-13333 | Protein | denotes | NIK |
T3903 | 12518-12523 | Protein | denotes | TRAF6 |
T3902 | 12499-12503 | Protein | denotes | TRIF |
T3901 | 12487-12492 | Protein | denotes | TRAF6 |
T3900 | 12427-12432 | Protein | denotes | TRAF6 |
T3899 | 12347-12352 | Protein | denotes | MyD88 |
T3898 | 12326-12330 | Protein | denotes | TRIF |
T3897 | 12281-12324 | Protein | denotes | TIR domain-containing adaptor-inducing IFNβ |
T3896 | 12270-12275 | Protein | denotes | MyD88 |
T3895 | 12220-12268 | Protein | denotes | myeloid differentiation primary response gene 88 |
T3894 | 12156-12160 | Protein | denotes | TRAM |
T3893 | 12125-12154 | Protein | denotes | TRIF-related adaptor molecule |
T3892 | 12116-12118 | Protein | denotes | Ma |
T3891 | 12060-12094 | Protein | denotes | Toll/IL-1 receptor adaptor protein |
T3890 | 11994-11998 | Protein | denotes | TLR4 |
T3889 | 11906-11910 | Protein | denotes | TAK1 |
T3888 | 11680-11683 | Protein | denotes | TNF |
T3887 | 11621-11625 | Protein | denotes | NEMO |
T3886 | 11529-11530 | Protein | denotes | 2 |
T3885 | 11524-11528 | Protein | denotes | TAB1 |
T3884 | 11515-11519 | Protein | denotes | NEMO |
T3883 | 11467-11471 | Protein | denotes | TAK1 |
T3882 | 11405-11409 | Protein | denotes | RIP1 |
T3881 | 11308-11312 | Protein | denotes | RIP1 |
T3880 | 11282-11283 | Protein | denotes | 2 |
T3879 | 11276-11281 | Protein | denotes | cIAP1 |
T3878 | 11270-11271 | Protein | denotes | 5 |
T3877 | 11264-11269 | Protein | denotes | TRAF2 |
T3876 | 11203-11207 | Protein | denotes | RIP1 |
T3875 | 11167-11170 | Protein | denotes | TNF |
T3874 | 11146-11151 | Protein | denotes | cIAP2 |
T3873 | 11101-11141 | Protein | denotes | cellular inhibitor of apoptosis (cIAP) 1 |
T3872 | 11050-11055 | Protein | denotes | TRAF5 |
T3871 | 11006-11045 | Protein | denotes | TNF receptor-associated factor (TRAF) 2 |
T3870 | 10935-10939 | Protein | denotes | RIP1 |
T3869 | 10903-10933 | Protein | denotes | receptor interacting protein 1 |
T3868 | 10881-10886 | Protein | denotes | TRADD |
T3867 | 10841-10879 | Protein | denotes | TNF receptor-1-associated death domain |
T3866 | 10795-10798 | Protein | denotes | TNF |
T3865 | 10782-10785 | Protein | denotes | TNF |
T3864 | 8474-8478 | Protein | denotes | IKK1 |
T3863 | 8460-8464 | Protein | denotes | NEMO |
T3862 | 8451-8455 | Protein | denotes | IKK2 |
T3861 | 8394-8398 | Protein | denotes | IKKγ |
T3860 | 8373-8377 | Protein | denotes | NEMO |
T3859 | 8346-8371 | Protein | denotes | NF-κB essential modulator |
T3858 | 8313-8317 | Protein | denotes | IKKβ |
T3857 | 8304-8308 | Protein | denotes | IKKα |
T3856 | 8284-8288 | Protein | denotes | IKK2 |
T3855 | 8275-8279 | Protein | denotes | IKK1 |
T3854 | 7830-7835 | Protein | denotes | RANKL |
T3853 | 7808-7811 | Protein | denotes | TNF |
T3852 | 7481-7484 | Protein | denotes | p50 |
T3851 | 7473-7476 | Protein | denotes | p52 |
T3850 | 7446-7450 | Protein | denotes | p105 |
T3849 | 7437-7441 | Protein | denotes | p100 |
T3848 | 7374-7379 | Protein | denotes | Bcl-3 |
T3847 | 7365-7369 | Protein | denotes | IκBξ |
T3846 | 7326-7332 | Protein | denotes | NF-κB2 |
T3845 | 7306-7310 | Protein | denotes | p100 |
T3844 | 7297-7303 | Protein | denotes | NF-κB1 |
T3843 | 7277-7281 | Protein | denotes | p105 |
T3842 | 7271-7275 | Protein | denotes | IκBε |
T3841 | 7265-7269 | Protein | denotes | IκBβ |
T3840 | 7259-7263 | Protein | denotes | IκBα |
T3917 | 13185-13188 | Protein | denotes | NIK |
T3916 | 13179-13182 | Protein | denotes | NIK |
T3915 | 13156-13177 | Protein | denotes | NF-κB inducing kinase |
T3914 | 13107-13111 | Protein | denotes | IKK1 |
T3913 | 12892-12896 | Protein | denotes | RelB |
T3912 | 12863-12866 | Protein | denotes | p52 |
T3911 | 12824-12828 | Protein | denotes | p100 |
T3910 | 12790-12794 | Protein | denotes | RANK |
T3909 | 12780-12784 | Protein | denotes | CD40 |
T3908 | 12765-12778 | Protein | denotes | BAFF receptor |
T3907 | 12741-12763 | Protein | denotes | lymphotoxin β receptor |
T3906 | 12662-12665 | Protein | denotes | TNF |
T3905 | 12597-12601 | Protein | denotes | TAK1 |
T3904 | 12533-12537 | Protein | denotes | RIP1 |
T1679 | 6147-6156 | Positive_regulation | denotes | increased |
T1678 | 6032-6040 | Localization | denotes | released |
T1677 | 5995-6003 | Localization | denotes | secreted |
T1676 | 4882-4891 | Gene_expression | denotes | producing |
T1675 | 4765-4775 | Gene_expression | denotes | expression |
T1674 | 4756-4764 | Positive_regulation | denotes | Enhanced |
T1673 | 4264-4273 | Gene_expression | denotes | expressed |
T1672 | 4207-4214 | Binding | denotes | Binding |
T1671 | 4146-4157 | Positive_regulation | denotes | upregulated |
T1670 | 3967-3976 | Gene_expression | denotes | expressed |
T1669 | 6759-6769 | Protein | denotes | tenascin C |
T1668 | 6749-6757 | Protein | denotes | biglycan |
T1667 | 6736-6747 | Protein | denotes | fibronectin |
T1666 | 6565-6569 | Protein | denotes | TLR4 |
T1665 | 6341-6367 | Protein | denotes | myeloid-related protein 14 |
T1664 | 6311-6336 | Protein | denotes | Myeloid-related protein 8 |
T1663 | 6248-6253 | Protein | denotes | HMGB1 |
T1662 | 6183-6188 | Protein | denotes | HMGB1 |
T1661 | 6138-6143 | Protein | denotes | HMGB1 |
T1660 | 6099-6111 | Protein | denotes | TLR4 ligands |
T1659 | 5954-5973 | Protein | denotes | chromatin component |
T1658 | 5927-5932 | Protein | denotes | HMGB1 |
T1657 | 5880-5925 | Protein | denotes | High mobility group box chromosomal protein 1 |
T1656 | 5011-5033 | Protein | denotes | lymphotoxin β receptor |
T1655 | 4957-4961 | Protein | denotes | BAFF |
T1654 | 4836-4840 | Protein | denotes | BAFF |
T1653 | 4810-4834 | Protein | denotes | B-cell activating factor |
T1652 | 4576-4580 | Protein | denotes | CD40 |
T1651 | 4302-4305 | Protein | denotes | CD4 |
T1650 | 4235-4240 | Protein | denotes | CD154 |
T1649 | 4222-4233 | Protein | denotes | CD40 ligand |
T1648 | 4197-4200 | Protein | denotes | TNF |
T1647 | 3919-3945 | Protein | denotes | TNF receptor family member |
T1646 | 3903-3907 | Protein | denotes | CD40 |
T1645 | 3789-3793 | Protein | denotes | RANK |
T1644 | 3693-3697 | Protein | denotes | RANK |
T1643 | 3664-3691 | Protein | denotes | receptor activator of NF-κB |
T1642 | 3450-3453 | Protein | denotes | TNF |
T1641 | 3375-3378 | Protein | denotes | TNF |
T1640 | 3316-3319 | Protein | denotes | TNF |
T280 | 2869-2880 | Binding | denotes | association |
T279 | 1836-1846 | Gene_expression | denotes | expression |
T278 | 1823-1831 | Regulation | denotes | regulate |
T277 | 2966-2971 | Protein | denotes | c-REL |
T276 | 2953-2960 | Protein | denotes | TNFAIP3 |
T275 | 2946-2951 | Protein | denotes | TRAF1 |
T274 | 2940-2944 | Protein | denotes | CD40 |
T273 | 2690-2695 | Protein | denotes | RANKL |
T272 | 2654-2688 | Protein | denotes | receptor activator of NF-κB ligand |
T271 | 2035-2038 | Protein | denotes | TNF |
T270 | 1932-1963 | Protein | denotes | inducible nitric oxide synthase |
T269 | 1901-1918 | Protein | denotes | cyclo-oxygenase-2 |
T268 | 1895-1899 | Protein | denotes | IL-6 |
T267 | 1884-1887 | Protein | denotes | TNF |
T266 | 1758-1763 | Protein | denotes | c-Rel |
T265 | 1752-1756 | Protein | denotes | RelB |
T264 | 1746-1750 | Protein | denotes | RelA |
T263 | 1739-1742 | Protein | denotes | p65 |
T262 | 1731-1737 | Protein | denotes | NF-κB1 |
T261 | 1723-1727 | Protein | denotes | p105 |
T260 | 1715-1721 | Protein | denotes | NF-κB2 |
T259 | 1707-1711 | Protein | denotes | p100 |
R206 | T261 | T278 | causeOf | p105,regulate |
R207 | T264 | T278 | causeOf | RelA,regulate |
R208 | T265 | T278 | causeOf | RelB,regulate |
R209 | T266 | T278 | causeOf | c-Rel,regulate |
R210 | T267 | T279 | themeOf | TNF,expression |
R211 | T268 | T279 | themeOf | IL-6,expression |
R212 | T269 | T279 | themeOf | cyclo-oxygenase-2,expression |
R213 | T270 | T279 | themeOf | inducible nitric oxide synthase,expression |
R214 | T273 | T272 | equivalentTo | RANKL,receptor activator of NF-κB ligand |
R215 | T274 | T280 | themeOf | CD40,association |
R216 | T275 | T280 | themeOf | TRAF1,association |
R217 | T276 | T280 | themeOf | TNFAIP3,association |
R218 | T277 | T280 | themeOf | c-REL,association |
R219 | T279 | T278 | themeOf | expression,regulate |
R1266 | T1644 | T1643 | equivalentTo | RANK,receptor activator of NF-κB |
R1267 | T1646 | T1670 | themeOf | CD40,expressed |
R1268 | T1647 | T1670 | themeOf | TNF receptor family member,expressed |
R1269 | T1648 | T1671 | causeOf | TNF,upregulated |
R1270 | T1649 | T1672 | themeOf | CD40 ligand,Binding |
R1271 | T1649 | T1673 | themeOf | CD40 ligand,expressed |
R1272 | T1650 | T1649 | equivalentTo | CD154,CD40 ligand |
R1273 | T1653 | T1675 | themeOf | B-cell activating factor,expression |
R1274 | T1654 | T1653 | equivalentTo | BAFF,B-cell activating factor |
R1275 | T1657 | T1659 | themeOf | High mobility group box chromosomal protein 1,chromatin component |
R1276 | T1657 | T1678 | themeOf | High mobility group box chromosomal protein 1,released |
R1277 | T1657 | T1677 | themeOf | High mobility group box chromosomal protein 1,secreted |
R1278 | T1658 | T1657 | equivalentTo | HMGB1,High mobility group box chromosomal protein 1 |
R1279 | T1659 | T1677 | themeOf | chromatin component,secreted |
R1280 | T1661 | T1679 | themeOf | HMGB1,increased |
R1281 | T1670 | T1671 | themeOf | expressed,upregulated |
R2776 | T3847 | T3954 | themeOf | IκBξ,inhibitors |
R2777 | T3848 | T3954 | themeOf | Bcl-3,inhibitors |
R2778 | T3867 | T3957 | themeOf | TNF receptor-1-associated death domain,recruitment |
R2779 | T3868 | T3867 | equivalentTo | TRADD,TNF receptor-1-associated death domain |
R2780 | T3869 | T3957 | themeOf | receptor interacting protein 1,recruitment |
R2781 | T3870 | T3867 | equivalentTo | RIP1,TNF receptor-1-associated death domain |
R2782 | T3870 | T3869 | equivalentTo | RIP1,receptor interacting protein 1 |
R2783 | T3871 | T3958 | themeOf | TNF receptor-associated factor (TRAF) 2,bind |
R2784 | T3872 | T3958 | themeOf | TRAF5,bind |
R2785 | T3873 | T3958 | themeOf | cellular inhibitor of apoptosis (cIAP) 1,bind |
R2786 | T3874 | T3958 | themeOf | cIAP2,bind |
R2787 | T3876 | T3959 | themeOf | RIP1,bound |
R2788 | T3883 | T3960 | themeOf | TAK1,recruit |
R2789 | T3890 | T3963 | causeOf | TLR4,induces |
R2790 | T3891 | T3964 | themeOf | Toll/IL-1 receptor adaptor protein,recruitment |
R2791 | T3893 | T3964 | themeOf | TRIF-related adaptor molecule,recruitment |
R2792 | T3894 | T3893 | equivalentTo | TRAM,TRIF-related adaptor molecule |
R2793 | T3896 | T3895 | equivalentTo | MyD88,myeloid differentiation primary response gene 88 |
R2794 | T3898 | T3897 | equivalentTo | TRIF,TIR domain-containing adaptor-inducing IFNβ |
R2795 | T3901 | T3966 | themeOf | TRAF6,selfubiquitination |
R2796 | T3902 | T3968 | themeOf | TRIF,interaction |
R2797 | T3902 | T3967 | themeOf | TRIF,recruits |
R2798 | T3903 | T3968 | themeOf | TRAF6,interaction |
R2799 | T3903 | T3967 | themeOf | TRAF6,recruits |
R2800 | T3904 | T3968 | themeOf | RIP1,interaction |
R2801 | T3904 | T3967 | themeOf | RIP1,recruits |
R2802 | T3905 | T3969 | themeOf | TAK1,activate |
R2803 | T3911 | T3970 | themeOf | p100,phosphorylation |
R2804 | T3915 | T3970 | causeOf | NF-κB inducing kinase,phosphorylation |
R2805 | T3916 | T3915 | equivalentTo | NIK,NF-κB inducing kinase |
R2806 | T3918 | T3973 | themeOf | NIK,degradation |
R2807 | T3919 | T3973 | themeOf | TRAF2,degradation |
R2808 | T3920 | T3973 | themeOf | TRAF3,degradation |
R2809 | T3921 | T3973 | themeOf | cIAP1,degradation |
R2810 | T3922 | T3973 | themeOf | 2,degradation |
R2811 | T3923 | T3973 | themeOf | NIK,degradation |
R2812 | T3928 | T3974 | themeOf | TRAF3,degradation |
R2813 | T3931 | T3976 | themeOf | IKK1,phosphorylation |
R2814 | T3935 | T3978 | themeOf | CD40,interact |
R2815 | T3935 | T3977 | themeOf | CD40,binding |
R2816 | T3936 | T3978 | themeOf | RANK,interact |
R2817 | T3937 | T3978 | themeOf | TRAF1,interact |
R2818 | T3938 | T3977 | themeOf | TRAF2,binding |
R2819 | T3938 | T3978 | themeOf | TRAF2,interact |
R2820 | T3939 | T3977 | themeOf | TRAF3,binding |
R2821 | T3939 | T3978 | themeOf | TRAF3,interact |
R2822 | T3940 | T3978 | themeOf | TRAF5,interact |
R2823 | T3940 | T3977 | themeOf | TRAF5,binding |
R2824 | T3941 | T3977 | themeOf | TRAF6,binding |
R2825 | T3941 | T3978 | themeOf | TRAF6,interact |
R2826 | T3942 | T3980 | themeOf | TRAF2,proteolysis |
R2827 | T3943 | T3980 | themeOf | TRAF3,proteolysis |
R2828 | T3945 | T3981 | causeOf | TRAF6,required |
R2829 | T3946 | T3982 | causeOf | CD40,mediated |
R2830 | T3947 | T3983 | themeOf | IL-6,production |
R2831 | T3952 | T3953 | locationOf | nuclear,translocation |
R2832 | T3953 | T3951 | themeOf | translocation,prevent |
R2833 | T3961 | T3962 | themeOf | ubiquitin-,binding |
R2834 | T3964 | T3963 | themeOf | recruitment,induces |
R2835 | T3972 | T3971 | themeOf | -translational,regulated |
R2836 | T3977 | T3979 | causeOf | binding,leads |
R2837 | T3978 | T3979 | causeOf | interact,leads |
R2838 | T3980 | T3979 | themeOf | proteolysis,leads |
R2839 | T3982 | T3981 | themeOf | mediated,required |
R2840 | T3983 | T3982 | themeOf | production,mediated |
R5567 | T8335 | T8344 | themeOf | IKK1,deficient |
R5568 | T8336 | T8345 | themeOf | IKK1,expressing |
R5569 | T8338 | T8347 | themeOf | IκBα,degradation |
R5570 | T8347 | T8346 | themeOf | degradation,enhanced |
R6327 | T9421 | T9477 | causeOf | A20,disrupts |
R6328 | T9423 | T9477 | causeOf | RIP2,disrupts |
R6329 | T9424 | T9477 | causeOf | TRAF6,disrupts |
R6330 | T9425 | T9477 | causeOf | MALT1,disrupts |
R6331 | T9427 | T9480 | themeOf | Ubc5hc,interactions |
R6332 | T9429 | T9480 | themeOf | TRAF2,interactions |
R6333 | T9430 | T9480 | themeOf | cIAP1,interactions |
R6334 | T9431 | T9480 | themeOf | 2,interactions |
R6335 | T9433 | T9481 | themeOf | A20,association |
R6336 | T9435 | T9482 | themeOf | Tax1-binding protein 1,inhibitor |
R6337 | T9438 | T9483 | themeOf | A20,deficient |
R6338 | T9439 | T9484 | themeOf | A20,deficient |
R6339 | T9441 | T9485 | themeOf | A20,lacking |
R6340 | T9444 | T9486 | themeOf | A20,lacking |
R6341 | T9445 | T9487 | themeOf | A20,expression |
R6342 | T9446 | T9488 | themeOf | A20,expression |
R6343 | T9447 | T9489 | causeOf | A20,regulated |
R6344 | T9448 | T9490 | themeOf | A20,expressing |
R6345 | T9449 | T9491 | themeOf | A20,expression |
R6346 | T9450 | T9492 | themeOf | TNF,decreased |
R6347 | T9451 | T9492 | themeOf | IL-1β,decreased |
R6348 | T9452 | T9492 | themeOf | IL-6,decreased |
R6349 | T9453 | T9492 | themeOf | RANKL,decreased |
R6350 | T9454 | T9492 | themeOf | monocyte chemo-attractant protein 1,decreased |
R6351 | T9456 | T9493 | causeOf | TNF,mediate |
R6352 | T9457 | T9493 | causeOf | IL-1β,mediate |
R6353 | T9458 | T9494 | themeOf | TNF,decreased |
R6354 | T9459 | T9494 | themeOf | IL-1β,decreased |
R6355 | T9463 | T9495 | themeOf | A20,lack |
R6356 | T9478 | T9477 | themeOf | interactions,disrupts |
R6357 | T9480 | T9479 | themeOf | interactions,disruption |
R6358 | T9488 | T9489 | themeOf | expression,regulated |
R8292 | T12514 | T12545 | causeOf | ABIN-1,inhibit |
R8293 | T12514 | T12544 | themeOf | ABIN-1,expressed |
R8294 | T12514 | T12547 | themeOf | ABIN-1,overexpression |
R8295 | T12515 | T12544 | themeOf | ABIN-2,expressed |
R8296 | T12516 | T12544 | themeOf | ABIN-3,expressed |
R8297 | T12517 | T12544 | themeOf | TNIP-1,expressed |
R8298 | T12518 | T12544 | themeOf | TNIP-2,expressed |
R8299 | T12520 | T12544 | themeOf | A20,expressed |
R8300 | T12521 | T12546 | causeOf | TNF,activation |
R8301 | T12522 | T12548 | themeOf | A20,target |
R8302 | T12523 | T12549 | themeOf | A20,expression |
R8303 | T12524 | T12549 | themeOf | ABIN-1,expression |
R8304 | T12525 | T12549 | themeOf | ABIN-3,expression |
R8305 | T12527 | T12551 | themeOf | ABIN-1,deficient |
R8306 | T12527 | T12552 | themeOf | ABIN-1,deficient |
R8307 | T12528 | T12552 | themeOf | ABIN-2,deficient |
R8308 | T12529 | T12554 | themeOf | ABIN-3,express |
R8309 | T12529 | T12553 | themeOf | ABIN-3,expressed |
R8310 | T12532 | T12556 | causeOf | ABIN-1,inhibits |
R8311 | T12534 | T12557 | themeOf | ABIN-1,deficient |
R8312 | T12537 | T12558 | causeOf | TNF,induced |
R8313 | T12541 | T12562 | themeOf | ABIN-3,expression |
R8314 | T12542 | T12562 | themeOf | A20,expression |
R8315 | T12546 | T12545 | themeOf | activation,inhibit |
R9294 | T14027 | T14026 | equivalentTo | CYLD,Cylindromatosis |
R9295 | T14041 | T14059 | themeOf | A20,expressed |
R9296 | T14047 | T14061 | themeOf | CYLD,expression |
R9297 | T14049 | T14063 | themeOf | TRAF6,recruited |
R9298 | T14052 | T14063 | themeOf | sequestosome 1,recruited |
R9299 | T14052 | T14064 | causeOf | sequestosome 1,via |
R9300 | T14063 | T14064 | themeOf | recruited,via |
R10157 | T15421 | T15420 | equivalentTo | SIGIRR,Single-immunoglobulin IL-1 receptor-related |
R10158 | T15423 | T15436 | themeOf | IL-1R,inhibitor |
R10159 | T15423 | T15437 | themeOf | IL-1R,interaction |
R10160 | T15424 | T15437 | themeOf | MyD88,interaction |
R10161 | T15425 | T15437 | themeOf | IRAK1,interaction |
R10162 | T15426 | T15437 | themeOf | TRAF6,interaction |
R10163 | T15429 | T15438 | themeOf | SIGIRR,expressed |
R10164 | T15432 | T15439 | themeOf | SIGIRR,deficient |
R10165 | T15433 | T15440 | themeOf | SIGIRR,expression |
R10166 | T15435 | T15442 | themeOf | SIGIRR,expression |
R10748 | T16289 | T16306 | themeOf | TRAF1,Expression |
R10749 | T16290 | T16307 | causeOf | TNF,inducible |
R10750 | T16291 | T16308 | themeOf | TRAF1,overexpression |
R10751 | T16293 | T16310 | themeOf | TRAF1,deficient |
R10752 | T16297 | T16311 | themeOf | TRAF1,deficient |
R10753 | T16300 | T16312 | themeOf | TRAF1,binding |
R10754 | T16301 | T16314 | themeOf | TRAF1,interact |
R10755 | T16301 | T16313 | themeOf | TRAF1,recruit |
R10756 | T16302 | T16313 | themeOf | A20,recruit |
R10757 | T16302 | T16314 | themeOf | A20,interact |
R10758 | T16306 | T16307 | themeOf | Expression,inducible |
R11370 | T17316 | T17347 | themeOf | miR-146a,induced |
R11371 | T17318 | T17347 | themeOf | miR-155,induced |
R11372 | T17319 | T17347 | causeOf | IL-1β,induced |
R11373 | T17320 | T17347 | causeOf | TNF,induced |
R11374 | T17325 | T17348 | themeOf | miR-155,target |
R11375 | T17326 | T17348 | themeOf | IKKε,target |
R11376 | T17327 | T17348 | themeOf | RIP1,target |
R11377 | T17328 | T17349 | themeOf | miR-155,expressed |
R11378 | T17329 | T17350 | themeOf | miR-146a,overexpressed |
R11379 | T17331 | T17351 | themeOf | IL-17,producing |
R11380 | T17333 | T17352 | themeOf | miR-155,overexpression |
R11381 | T17334 | T17354 | causeOf | miR-155,promote |
R11382 | T17335 | T17355 | themeOf | TNF,production |
R11383 | T17338 | T17357 | causeOf | miR-124a,regulator |
R11384 | T17339 | T17357 | themeOf | monocyte chemoattractant protein 1,regulator |
R11385 | T17341 | T17360 | themeOf | matrix metalloproteinase-1,secretion |
R11386 | T17342 | T17360 | themeOf | IL-6,secretion |
R11387 | T17343 | T17361 | themeOf | miR-16,expression |
R11388 | T17344 | T17361 | themeOf | miR-132,expression |
R11389 | T17345 | T17361 | themeOf | miR-223,expression |
R11390 | T17355 | T17354 | themeOf | production,promote |
R11391 | T17360 | T17359 | themeOf | secretion,increased |
R12749 | T19260 | T19316 | themeOf | TNFR1,engagement |
R12750 | T19261 | T19316 | themeOf | CD40,engagement |
R12751 | T19262 | T19316 | themeOf | RANK,engagement |
R12752 | T19263 | T19317 | causeOf | TLR4,trigger |
R12753 | T19263 | T19316 | themeOf | TLR4,engagement |
R12754 | T19264 | T19318 | themeOf | TNF receptor 1-associated death domain protein,recruitment |
R12755 | T19266 | T19318 | themeOf | MyD88,recruitment |
R12756 | T19267 | T19318 | themeOf | MAL,recruitment |
R12757 | T19268 | T19318 | themeOf | TIR domain-containing adaptor-inducing IFNβ,recruitment |
R12758 | T19269 | T19268 | equivalentTo | TRIF,TIR domain-containing adaptor-inducing IFNβ |
R12759 | T19270 | T19268 | equivalentTo | RIP1,TIR domain-containing adaptor-inducing IFNβ |
R12760 | T19271 | T19318 | themeOf | IRAK1,recruitment |
R12761 | T19272 | T19318 | themeOf | IRAK4,recruitment |
R12762 | T19273 | T19268 | equivalentTo | TRAF2,TIR domain-containing adaptor-inducing IFNβ |
R12763 | T19274 | T19318 | themeOf | TRAF6,recruitment |
R12764 | T19275 | T19318 | themeOf | cIAP1,recruitment |
R12765 | T19276 | T19318 | themeOf | cIAP2,recruitment |
R12766 | T19283 | T19321 | themeOf | IKK2,degradation |
R12767 | T19284 | T19320 | themeOf | IκBα,phosphorylates |
R12768 | T19285 | T19322 | themeOf | p65,translocate |
R12769 | T19286 | T19322 | themeOf | p50,translocate |
R12770 | T19290 | T19324 | themeOf | RIP1,recruited |
R12771 | T19291 | T19324 | themeOf | TRAF6,recruited |
R12772 | T19292 | T19324 | themeOf | ABIN-1,recruited |
R12773 | T19293 | T19324 | themeOf | p62,recruited |
R12774 | T19294 | T19327 | themeOf | IRAK1,expression |
R12775 | T19295 | T19327 | themeOf | TRAF6,expression |
R12776 | T19296 | T19328 | causeOf | SIGIRR,inhibited |
R12777 | T19297 | T19330 | themeOf | TLR4,binding |
R12778 | T19298 | T19330 | themeOf | IRAK1,binding |
R12779 | T19299 | T19330 | themeOf | TRAF6,binding |
R12780 | T19304 | T19331 | themeOf | MyD88,inhibitor |
R12781 | T19305 | T19331 | themeOf | myeloid differentiation primary response gene 88,inhibitor |
R12782 | T19306 | T19331 | themeOf | NEMO,inhibitor |
R12783 | T19307 | T19331 | themeOf | NF-κB essential modulator,inhibitor |
R12784 | T19308 | T19331 | themeOf | RANK,inhibitor |
R12785 | T19309 | T19331 | themeOf | receptor activator of NF-κB,inhibitor |
R12786 | T19309 | T19308 | themeOf | receptor activator of NF-κB,RANK |
R12787 | T19310 | T19331 | themeOf | RIP1,inhibitor |
R12788 | T19311 | T19331 | themeOf | receptor interacting protein 1,inhibitor |
R12789 | T19312 | T19331 | themeOf | SIGIRR,inhibitor |
R12790 | T19313 | T19331 | themeOf | single-immunoglobulinIL-1 receptor-related,inhibitor |
R12791 | T19314 | T19308 | themeOf | TNF,RANK |
R12792 | T19314 | T19331 | themeOf | TNF,inhibitor |
R12793 | T19315 | T19331 | themeOf | tumour necrosis factor,inhibitor |
R12794 | T19318 | T19317 | themeOf | recruitment,trigger |
R12795 | T19319 | T19317 | themeOf | inducing,trigger |
R12796 | T19323 | T19322 | locationOf | nucleus,translocate |
R12797 | T19327 | T19326 | themeOf | expression,inhibiting |
R12798 | T19330 | T19329 | themeOf | binding,compete |
R13906 | T21285 | T21317 | themeOf | NF-κB inducing kinase,expression |
R13907 | T21286 | T21285 | equivalentTo | NIK,NF-κB inducing kinase |
R13908 | T21292 | T21318 | themeOf | NIK,degradation |
R13909 | T21294 | T21319 | themeOf | TRAF3,recruited |
R13910 | T21304 | T21320 | themeOf | NIK,increased |
R13911 | T21305 | T21321 | themeOf | NIK,phosphorylates |
R13912 | T21306 | T21321 | themeOf | IKK1,phosphorylates |
R13913 | T21306 | T21322 | causeOf | IKK1,mediates |
R13914 | T21307 | T21323 | themeOf | p100,phosphorylation |
R13915 | T21308 | T21324 | themeOf | p100,degradation |
R13916 | T21309 | T21324 | themeOf | p52,degradation |
R13917 | T21323 | T21322 | themeOf | phosphorylation,mediates |
bionlp-st-ge-2016-spacy-parsed
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T114 | 0-8 | JJ | denotes | Negative |
T115 | 9-19 | NN | denotes | regulation |
T116 | 20-22 | IN | denotes | of |
T117 | 23-28 | NNP | denotes | NF-κB |
T118 | 29-32 | CC | denotes | and |
T119 | 33-36 | PRP$ | denotes | its |
T120 | 37-48 | NN | denotes | involvement |
T121 | 49-51 | IN | denotes | in |
T122 | 52-62 | JJ | denotes | rheumatoid |
T123 | 63-72 | NNS | denotes | arthritis |
T22073 | 15165-15166 | . | denotes | . |
T22072 | 15159-15165 | NN | denotes | factor |
T22071 | 15150-15158 | NN | denotes | necrosis |
T22070 | 15143-15149 | NN | denotes | tumour |
T22069 | 15141-15142 | , | denotes | , |
T22068 | 15138-15141 | NNP | denotes | TNF |
T22067 | 15136-15137 | : | denotes | ; |
T22066 | 15130-15136 | NN | denotes | factor |
T22065 | 15110-15129 | VBD | denotes | receptor-associated |
T22064 | 15106-15109 | NNP | denotes | TNF |
T22063 | 15104-15105 | , | denotes | , |
T22062 | 15100-15104 | NNP | denotes | TRAF |
T22061 | 15098-15099 | : | denotes | ; |
T22060 | 15093-15098 | NN | denotes | NF-κB |
T22059 | 15090-15092 | IN | denotes | of |
T22058 | 15080-15089 | NN | denotes | activator |
T22057 | 15071-15079 | NN | denotes | receptor |
T22056 | 15069-15070 | , | denotes | , |
T22055 | 15065-15069 | NNP | denotes | RANK |
T22054 | 15063-15064 | : | denotes | ; |
T22053 | 15057-15063 | NN | denotes | factor |
T22052 | 15049-15056 | JJ | denotes | nuclear |
T22051 | 15047-15048 | , | denotes | , |
T22050 | 15045-15047 | NNP | denotes | NF |
T22049 | 15043-15044 | : | denotes | ; |
T22048 | 15037-15043 | NN | denotes | kinase |
T22047 | 15033-15036 | NNP | denotes | IκB |
T22046 | 15031-15032 | , | denotes | , |
T22045 | 15028-15031 | NNP | denotes | IKK |
T22044 | 15026-15027 | : | denotes | ; |
T22043 | 15017-15026 | NN | denotes | apoptosis |
T22042 | 15014-15016 | IN | denotes | of |
T22041 | 15004-15013 | NN | denotes | inhibitor |
T22040 | 14995-15003 | JJ | denotes | cellular |
T22039 | 14993-14994 | , | denotes | , |
T22038 | 14989-14993 | NNP | denotes | cIAP |
T22037 | 14987-14988 | . | denotes | . |
T22036 | 14980-14987 | NNS | denotes | factors |
T22035 | 14960-14979 | JJ | denotes | receptor-associated |
T22034 | 14956-14959 | NNP | denotes | TNF |
T22033 | 14950-14955 | JJ | denotes | other |
T22032 | 14945-14949 | IN | denotes | with |
T22031 | 14935-14944 | VBG | denotes | competing |
T22030 | 14932-14934 | IN | denotes | by |
T22029 | 14923-14931 | RB | denotes | probably |
T22028 | 14918-14922 | JJS | denotes | most |
T22027 | 14916-14917 | , | denotes | , |
T22026 | 14909-14916 | NN | denotes | pathway |
T22025 | 14904-14908 | DT | denotes | this |
T22024 | 14901-14903 | IN | denotes | of |
T22023 | 14891-14900 | NN | denotes | regulator |
T22022 | 14882-14890 | JJ | denotes | negative |
T22021 | 14880-14881 | DT | denotes | a |
T22020 | 14877-14879 | IN | denotes | as |
T22019 | 14866-14876 | VBN | denotes | identified |
T22018 | 14861-14865 | VBN | denotes | been |
T22017 | 14856-14860 | RB | denotes | also |
T22016 | 14852-14855 | VBZ | denotes | has |
T22015 | 14846-14851 | CD | denotes | TRAF1 |
T22014 | 14844-14845 | , | denotes | , |
T22013 | 14839-14844 | CD | denotes | TRAF3 |
T22012 | 14836-14838 | TO | denotes | to |
T22011 | 14831-14835 | JJ | denotes | Next |
T22010 | 14829-14830 | . | denotes | . |
T22009 | 14816-14829 | NN | denotes | transcription |
T22008 | 14807-14815 | VB | denotes | activate |
T22007 | 14804-14806 | TO | denotes | to |
T22006 | 14799-14803 | NNP | denotes | RelB |
T22005 | 14794-14798 | IN | denotes | with |
T22004 | 14782-14793 | NN | denotes | heterodimer |
T22003 | 14780-14781 | DT | denotes | a |
T22002 | 14774-14779 | VBZ | denotes | forms |
T22001 | 14768-14773 | WDT | denotes | which |
T22000 | 14766-14767 | , | denotes | , |
T21999 | 14763-14766 | CD | denotes | p52 |
T21998 | 14760-14762 | TO | denotes | to |
T21997 | 14755-14759 | CD | denotes | p100 |
T21996 | 14752-14754 | IN | denotes | of |
T21995 | 14740-14751 | NN | denotes | degradation |
T21994 | 14728-14739 | JJ | denotes | proteasomal |
T21993 | 14720-14727 | JJ | denotes | partial |
T21992 | 14716-14719 | CC | denotes | and |
T21991 | 14697-14715 | NN | denotes | polyubiquitination |
T21990 | 14686-14696 | JJ | denotes | K48-linked |
T21989 | 14683-14685 | IN | denotes | by |
T21988 | 14674-14682 | VBN | denotes | followed |
T21987 | 14671-14673 | VBZ | denotes | is |
T21986 | 14666-14670 | DT | denotes | This |
T21985 | 14664-14665 | . | denotes | . |
T21984 | 14649-14664 | NN | denotes | phosphorylation |
T21983 | 14644-14648 | CD | denotes | p100 |
T21982 | 14638-14643 | NNP | denotes | NF-κB |
T21981 | 14629-14637 | VBZ | denotes | mediates |
T21980 | 14623-14628 | WDT | denotes | which |
T21979 | 14621-14622 | , | denotes | , |
T21978 | 14617-14621 | NNP | denotes | IKK1 |
T21977 | 14607-14616 | VBZ | denotes | activates |
T21976 | 14603-14606 | CC | denotes | and |
T21975 | 14588-14602 | VBZ | denotes | phosphorylates |
T21974 | 14583-14587 | RB | denotes | then |
T21973 | 14579-14582 | NNP | denotes | NIK |
T21972 | 14577-14578 | . | denotes | . |
T21971 | 14573-14577 | NN | denotes | cell |
T21970 | 14569-14572 | DT | denotes | the |
T21969 | 14566-14568 | IN | denotes | in |
T21968 | 14559-14565 | NNS | denotes | levels |
T21967 | 14555-14558 | NNP | denotes | NIK |
T21966 | 14545-14554 | VBN | denotes | increased |
T21965 | 14542-14544 | IN | denotes | in |
T21964 | 14532-14541 | VBG | denotes | resulting |
T21963 | 14530-14531 | , | denotes | , |
T21962 | 14520-14530 | VBN | denotes | stabilised |
T21961 | 14517-14519 | VBZ | denotes | is |
T21960 | 14513-14516 | NNP | denotes | NIK |
T21959 | 14509-14512 | CC | denotes | and |
T21958 | 14500-14508 | JJ | denotes | degraded |
T21957 | 14497-14499 | VBZ | denotes | is |
T21956 | 14491-14496 | CD | denotes | TRAF3 |
T21955 | 14489-14490 | , | denotes | , |
T21954 | 14483-14489 | NN | denotes | result |
T21953 | 14481-14482 | DT | denotes | a |
T21952 | 14478-14480 | IN | denotes | As |
T21951 | 14476-14477 | . | denotes | . |
T21950 | 14473-14476 | NNP | denotes | NIK |
T21949 | 14468-14472 | IN | denotes | than |
T21948 | 14461-14467 | RB | denotes | rather |
T21902 | 14144-14162 | NN | denotes | polyubiquitination |
T21901 | 14133-14143 | JJ | denotes | K48-linked |
T21900 | 14129-14132 | DT | denotes | the |
T21899 | 14117-14128 | VBZ | denotes | facilitates |
T21898 | 14111-14116 | WDT | denotes | which |
T21897 | 14109-14110 | , | denotes | , |
T21896 | 14102-14109 | NNP | denotes | cIAP1/2 |
T21895 | 14098-14101 | CC | denotes | and |
T21894 | 14092-14097 | CD | denotes | TRAF3 |
T21893 | 14090-14091 | , | denotes | , |
T21892 | 14085-14090 | CD | denotes | TRAF2 |
T21891 | 14077-14084 | VBZ | denotes | ligases |
T21890 | 14067-14076 | NN | denotes | ubiquitin |
T21889 | 14063-14066 | DT | denotes | the |
T21888 | 14058-14062 | IN | denotes | with |
T21887 | 14050-14057 | NN | denotes | complex |
T21886 | 14040-14049 | JJ | denotes | cytosolic |
T21885 | 14038-14039 | DT | denotes | a |
T21884 | 14032-14037 | VBZ | denotes | forms |
T21883 | 14028-14031 | NNP | denotes | NIK |
T21882 | 14022-14027 | NNS | denotes | cells |
T21881 | 14009-14021 | JJ | denotes | unstimulated |
T21880 | 14006-14008 | IN | denotes | In |
T21879 | 14004-14005 | . | denotes | . |
T21878 | 13998-14004 | NNS | denotes | levels |
T21877 | 13987-13997 | NN | denotes | expression |
T21876 | 13985-13986 | -RRB- | denotes | ) |
T21875 | 13982-13985 | NNP | denotes | NIK |
T21874 | 13981-13982 | -LRB- | denotes | ( |
T21873 | 13974-13980 | NN | denotes | kinase |
T21872 | 13965-13973 | VBG | denotes | inducing |
T21871 | 13959-13964 | JJ | denotes | NF-κB |
T21870 | 13956-13958 | IN | denotes | on |
T21869 | 13946-13955 | JJ | denotes | dependent |
T21868 | 13943-13945 | VBZ | denotes | is |
T21867 | 13938-13942 | WDT | denotes | that |
T21866 | 13930-13937 | NN | denotes | pathway |
T21865 | 13924-13929 | NN | denotes | NF-κB |
T21864 | 13911-13923 | JJ | denotes | noncanonical |
T21863 | 13907-13910 | DT | denotes | the |
T21862 | 13898-13906 | VB | denotes | activate |
T21861 | 13894-13897 | MD | denotes | can |
T21860 | 13889-13893 | NNP | denotes | RANK |
T21859 | 13885-13888 | CC | denotes | and |
T21858 | 13880-13884 | CD | denotes | CD40 |
T21857 | 13878-13879 | . | denotes | . |
T21856 | 13868-13878 | VBG | denotes | signalling |
T21855 | 13862-13867 | NNP | denotes | NF-κB |
T21854 | 13849-13861 | NNP | denotes | Noncanonical |
T20557 | 10723-10724 | . | denotes | . |
T20556 | 10717-10723 | NN | denotes | factor |
T20555 | 10708-10716 | NN | denotes | necrosis |
T20554 | 10701-10707 | NN | denotes | tumour |
T20553 | 10699-10700 | , | denotes | , |
T20552 | 10696-10699 | NNP | denotes | TNF |
T20551 | 10694-10695 | : | denotes | ; |
T20550 | 10686-10694 | NN | denotes | receptor |
T20549 | 10676-10685 | JJ | denotes | Toll-like |
T20548 | 10674-10675 | , | denotes | , |
T20547 | 10671-10674 | NNP | denotes | TLR |
T20546 | 10669-10670 | : | denotes | ; |
T20545 | 10663-10669 | NN | denotes | factor |
T20544 | 10643-10662 | VBD | denotes | receptor-associated |
T20543 | 10639-10642 | NNP | denotes | TNF |
T20542 | 10637-10638 | , | denotes | , |
T20541 | 10633-10637 | NNP | denotes | TRAF |
T20540 | 10631-10632 | : | denotes | ; |
T20539 | 10630-10631 | NN | denotes | R |
T20538 | 10628-10630 | CD | denotes | -1 |
T20537 | 10617-10628 | NNP | denotes | receptor/IL |
T20536 | 10607-10616 | JJ | denotes | Toll-like |
T20535 | 10605-10606 | , | denotes | , |
T20534 | 10602-10605 | NNP | denotes | TIR |
T20533 | 10600-10601 | : | denotes | ; |
T20532 | 10584-10600 | JJ | denotes | receptor-related |
T20531 | 10558-10583 | JJ | denotes | single-immunoglobulinIL-1 |
T20530 | 10556-10557 | , | denotes | , |
T20529 | 10550-10556 | NNP | denotes | SIGIRR |
T20528 | 10548-10549 | : | denotes | ; |
T20527 | 10547-10548 | CD | denotes | 1 |
T20526 | 10539-10546 | NN | denotes | protein |
T20525 | 10527-10538 | VBG | denotes | interacting |
T20524 | 10518-10526 | NN | denotes | receptor |
T20523 | 10516-10517 | , | denotes | , |
T20522 | 10512-10516 | NNP | denotes | RIP1 |
T20521 | 10510-10511 | : | denotes | ; |
T20520 | 10505-10510 | NNP | denotes | NF-κB |
T20519 | 10502-10504 | IN | denotes | of |
T20518 | 10492-10501 | NN | denotes | activator |
T20517 | 10483-10491 | NN | denotes | receptor |
T20516 | 10481-10482 | , | denotes | , |
T20515 | 10477-10481 | NNP | denotes | RANK |
T20514 | 10475-10476 | : | denotes | ; |
T20513 | 10469-10475 | NN | denotes | factor |
T20512 | 10461-10468 | JJ | denotes | nuclear |
T20511 | 10459-10460 | , | denotes | , |
T20510 | 10457-10459 | NNP | denotes | NF |
T20509 | 10455-10456 | : | denotes | ; |
T20508 | 10446-10455 | NN | denotes | modulator |
T20507 | 10436-10445 | JJ | denotes | essential |
T20506 | 10430-10435 | NNP | denotes | NF-κB |
T20505 | 10428-10429 | , | denotes | , |
T20504 | 10424-10428 | NNP | denotes | NEMO |
T20503 | 10422-10423 | : | denotes | ; |
T20502 | 10420-10422 | CD | denotes | 88 |
T20501 | 10415-10419 | NN | denotes | gene |
T20500 | 10406-10414 | NN | denotes | response |
T20499 | 10398-10405 | JJ | denotes | primary |
T20498 | 10382-10397 | NN | denotes | differentiation |
T20497 | 10374-10381 | JJ | denotes | myeloid |
T20496 | 10372-10373 | , | denotes | , |
T20495 | 10367-10372 | NNP | denotes | MyD88 |
T20494 | 10365-10366 | : | denotes | ; |
T20493 | 10359-10365 | NN | denotes | kinase |
T20492 | 10342-10358 | JJ | denotes | IL-1R-associated |
T20491 | 10340-10341 | , | denotes | , |
T20490 | 10336-10340 | NNP | denotes | IRAK |
T20489 | 10334-10335 | : | denotes | ; |
T20488 | 10329-10334 | NN | denotes | NF-κB |
T20487 | 10326-10328 | IN | denotes | of |
T20486 | 10316-10325 | NN | denotes | inhibitor |
T20485 | 10314-10315 | , | denotes | , |
T20484 | 10311-10314 | NNP | denotes | IκB |
T20483 | 10309-10310 | : | denotes | ; |
T20482 | 10303-10309 | NN | denotes | kinase |
T20481 | 10299-10302 | NNP | denotes | IκB |
T20480 | 10297-10298 | , | denotes | , |
T20479 | 10294-10297 | NNP | denotes | IKK |
T20478 | 10292-10293 | : | denotes | ; |
T20477 | 10277-10292 | NN | denotes | cylindromatosis |
T20476 | 10275-10276 | , | denotes | , |
T20475 | 10271-10275 | NNP | denotes | CYLD |
T20474 | 10269-10270 | : | denotes | ; |
T20473 | 10260-10269 | NN | denotes | apoptosis |
T20472 | 10257-10259 | IN | denotes | of |
T20471 | 10247-10256 | NN | denotes | inhibitor |
T20470 | 10238-10246 | JJ | denotes | cellular |
T20469 | 10236-10237 | , | denotes | , |
T20468 | 10232-10236 | NNP | denotes | cIAP |
T20467 | 10230-10231 | : | denotes | ; |
T20466 | 10225-10230 | NN | denotes | NF-κB |
T20465 | 10222-10224 | IN | denotes | of |
T20464 | 10212-10221 | NN | denotes | inhibitor |
T20463 | 10200-10211 | JJ | denotes | A20-binding |
T20462 | 10198-10199 | , | denotes | , |
T20461 | 10194-10198 | NNP | denotes | ABIN |
T20460 | 10192-10193 | . | denotes | . |
T20459 | 10182-10192 | NN | denotes | activation |
T20404 | 9861-9866 | NNP | denotes | IRAK1 |
T20403 | 9858-9860 | IN | denotes | of |
T20402 | 9847-9857 | NN | denotes | expression |
T20401 | 9836-9846 | VBG | denotes | inhibiting |
T20400 | 9833-9835 | IN | denotes | by |
T20399 | 9822-9832 | JJ | denotes | signalling |
T20398 | 9818-9821 | NNP | denotes | TLR |
T20397 | 9809-9817 | VB | denotes | regulate |
T20396 | 9798-9808 | RB | denotes | negatively |
T20395 | 9795-9797 | TO | denotes | to |
T20394 | 9787-9794 | VBN | denotes | thought |
T20393 | 9784-9786 | VBZ | denotes | is |
T20392 | 9776-9783 | NN | denotes | miR-146 |
T20391 | 9774-9775 | . | denotes | . |
T20390 | 9771-9774 | CD | denotes | p62 |
T20389 | 9767-9770 | CC | denotes | and |
T20388 | 9760-9766 | NNP | denotes | ABIN-1 |
T20387 | 9757-9759 | IN | denotes | as |
T20386 | 9752-9756 | JJ | denotes | such |
T20385 | 9743-9751 | NNS | denotes | proteins |
T20384 | 9735-9742 | NN | denotes | adaptor |
T20383 | 9717-9734 | JJ | denotes | ubiquitin-binding |
T20382 | 9708-9716 | JJ | denotes | specific |
T20381 | 9702-9707 | VBG | denotes | using |
T20380 | 9692-9701 | VBN | denotes | recruited |
T20379 | 9688-9691 | VBP | denotes | are |
T20378 | 9683-9687 | PRP | denotes | they |
T20377 | 9677-9682 | WDT | denotes | which |
T20376 | 9674-9676 | TO | denotes | to |
T20375 | 9672-9673 | , | denotes | , |
T20374 | 9667-9672 | NNP | denotes | TRAF6 |
T20373 | 9663-9666 | CC | denotes | and |
T20372 | 9658-9662 | NNP | denotes | RIP1 |
T20371 | 9648-9657 | VBG | denotes | including |
T20370 | 9639-9647 | NNS | denotes | proteins |
T20369 | 9628-9638 | VBG | denotes | signalling |
T20368 | 9619-9627 | JJ | denotes | specific |
T20367 | 9609-9618 | VBG | denotes | targeting |
T20366 | 9606-9608 | IN | denotes | by |
T20365 | 9595-9605 | NN | denotes | activation |
T20364 | 9589-9594 | JJ | denotes | NF-κB |
T20363 | 9581-9588 | VBP | denotes | control |
T20362 | 9576-9580 | WDT | denotes | that |
T20361 | 9568-9575 | NNS | denotes | enzymes |
T20360 | 9551-9567 | VBG | denotes | deubiquitinating |
T20359 | 9547-9550 | VBP | denotes | are |
T20358 | 9542-9546 | NNP | denotes | CYLD |
T20357 | 9538-9541 | CC | denotes | and |
T20356 | 9534-9537 | CD | denotes | A20 |
T20355 | 9532-9533 | . | denotes | . |
T20354 | 9527-9532 | NNS | denotes | TRAFs |
T20353 | 9521-9526 | JJ | denotes | other |
T20352 | 9516-9520 | IN | denotes | with |
T20351 | 9506-9515 | VBG | denotes | competing |
T20350 | 9503-9505 | IN | denotes | by |
T20349 | 9494-9502 | RB | denotes | probably |
T20348 | 9489-9493 | JJS | denotes | most |
T20347 | 9487-9488 | , | denotes | , |
T20346 | 9477-9487 | NN | denotes | activation |
T20345 | 9471-9476 | JJ | denotes | NF-κB |
T20344 | 9462-9470 | VB | denotes | regulate |
T20343 | 9451-9461 | RB | denotes | negatively |
T20342 | 9447-9450 | MD | denotes | can |
T20341 | 9445-9446 | , | denotes | , |
T20340 | 9437-9445 | NN | denotes | activity |
T20339 | 9430-9436 | NN | denotes | ligase |
T20338 | 9420-9429 | NN | denotes | ubiquitin |
T20337 | 9417-9419 | DT | denotes | no |
T20336 | 9413-9416 | VBZ | denotes | has |
T20335 | 9407-9412 | WDT | denotes | which |
T20334 | 9405-9406 | , | denotes | , |
T20333 | 9400-9405 | CD | denotes | TRAF1 |
T20332 | 9398-9399 | . | denotes | . |
T20331 | 9388-9398 | NN | denotes | expression |
T20330 | 9383-9387 | NN | denotes | gene |
T20329 | 9376-9382 | NN | denotes | target |
T20328 | 9368-9375 | VB | denotes | promote |
T20327 | 9364-9367 | CC | denotes | and |
T20326 | 9356-9363 | NN | denotes | nucleus |
T20325 | 9352-9355 | DT | denotes | the |
T20324 | 9349-9351 | TO | denotes | to |
T20323 | 9337-9348 | VB | denotes | translocate |
T20322 | 9334-9336 | TO | denotes | to |
T20321 | 9332-9333 | -RRB- | denotes | ) |
T20320 | 9329-9332 | CD | denotes | p50 |
T20319 | 9325-9328 | CC | denotes | and |
T20318 | 9321-9324 | CD | denotes | p65 |
T20317 | 9318-9320 | IN | denotes | of |
T20316 | 9306-9317 | NN | denotes | heterodimer |
T20315 | 9304-9305 | DT | denotes | a |
T20314 | 9301-9303 | IN | denotes | as |
T20313 | 9295-9300 | VBN | denotes | shown |
T20312 | 9290-9294 | RB | denotes | here |
T20311 | 9289-9290 | -LRB- | denotes | ( |
T20310 | 9283-9288 | NNP | denotes | NF-κB |
T20309 | 9276-9282 | VBZ | denotes | allows |
T20308 | 9271-9275 | DT | denotes | This |
T20307 | 9269-9270 | . | denotes | . |
T20306 | 9258-9269 | NN | denotes | degradation |
T20305 | 9246-9257 | JJ | denotes | proteasomal |
T20304 | 9242-9245 | CC | denotes | and |
T20303 | 9227-9241 | NN | denotes | ubiquitination |
T20302 | 9216-9226 | JJ | denotes | K48-linked |
T20301 | 9212-9215 | PRP$ | denotes | its |
T20300 | 9201-9211 | VBG | denotes | triggering |
T20299 | 9199-9200 | , | denotes | , |
T20298 | 9195-9199 | NNP | denotes | IκBα |
T20297 | 9180-9194 | NNS | denotes | phosphorylates |
T20296 | 9175-9179 | NN | denotes | turn |
T20295 | 9172-9174 | IN | denotes | in |
T20294 | 9166-9171 | WDT | denotes | which |
T20293 | 9164-9165 | , | denotes | , |
T20292 | 9160-9164 | NNP | denotes | IKK2 |
T20291 | 9150-9159 | VBZ | denotes | activates |
T20290 | 9146-9149 | CC | denotes | and |
T20289 | 9131-9145 | VBZ | denotes | phosphorylates |
T20288 | 9126-9130 | RB | denotes | then |
T20287 | 9121-9125 | CD | denotes | TAK1 |
T20286 | 9119-9120 | . | denotes | . |
T20285 | 9115-9119 | CD | denotes | TAK1 |
T20284 | 9111-9114 | CC | denotes | and |
T20283 | 9106-9110 | CD | denotes | IKK2 |
T20282 | 9093-9105 | RB | denotes | respectively |
T20281 | 9090-9092 | IN | denotes | of |
T20280 | 9079-9089 | NN | denotes | activation |
T20279 | 9075-9078 | CC | denotes | and |
T20278 | 9063-9074 | NN | denotes | recruitment |
T20277 | 9059-9062 | DT | denotes | the |
T20276 | 9056-9058 | IN | denotes | in |
T20275 | 9046-9055 | VBG | denotes | resulting |
T20274 | 9044-9045 | , | denotes | , |
T20273 | 9036-9044 | NNS | denotes | proteins |
T20272 | 9032-9035 | NNP | denotes | TAB |
T20271 | 9028-9031 | CC | denotes | and |
T20270 | 9023-9027 | NNP | denotes | NEMO |
T20269 | 9020-9022 | IN | denotes | by |
T20268 | 9009-9019 | VBN | denotes | recognised |
T20267 | 9006-9008 | VBZ | denotes | is |
T20266 | 9004-9005 | , | denotes | , |
T20265 | 8999-9004 | NNP | denotes | IRAK1 |
T20264 | 8995-8998 | CC | denotes | and |
T20263 | 8990-8994 | NNP | denotes | RIP1 |
T20262 | 8988-8989 | , | denotes | , |
T20261 | 8983-8988 | NNP | denotes | TRAFs |
T20260 | 8980-8982 | IN | denotes | of |
T20259 | 8961-8979 | NN | denotes | polyubiquitination |
T20258 | 8950-8960 | JJ | denotes | K63-linked |
T20257 | 8948-8949 | . | denotes | . |
T20256 | 8940-8948 | NN | denotes | receptor |
T20255 | 8936-8939 | DT | denotes | the |
T20254 | 8933-8935 | TO | denotes | to |
T20253 | 8931-8932 | -RRB- | denotes | ) |
T20252 | 8926-8931 | NNP | denotes | cIAP2 |
T20251 | 8924-8925 | , | denotes | , |
T20250 | 8919-8924 | NNP | denotes | cIAP1 |
T20249 | 8917-8918 | , | denotes | , |
T20248 | 8912-8917 | CD | denotes | TRAF6 |
T20247 | 8910-8911 | , | denotes | , |
T20246 | 8905-8910 | CD | denotes | TRAF2 |
T20245 | 8904-8905 | -LRB- | denotes | ( |
T20244 | 8896-8903 | NNS | denotes | ligases |
T20243 | 8886-8895 | NN | denotes | ubiquitin |
T20242 | 8882-8885 | CC | denotes | and |
T20241 | 8880-8881 | , | denotes | , |
T20240 | 8879-8880 | -RRB- | denotes | ) |
T20239 | 8874-8879 | NNP | denotes | IRAK4 |
T20238 | 8872-8873 | , | denotes | , |
T20237 | 8867-8872 | NNP | denotes | IRAK1 |
T20236 | 8865-8866 | , | denotes | , |
T20235 | 8861-8865 | CD | denotes | RIP1 |
T20234 | 8860-8861 | -LRB- | denotes | ( |
T20233 | 8852-8859 | NNS | denotes | kinases |
T20232 | 8850-8851 | , | denotes | , |
T20231 | 8849-8850 | -RRB- | denotes | ) |
T20230 | 8848-8849 | -RRB- | denotes | ) |
T20229 | 8844-8848 | NNP | denotes | TRIF |
T20228 | 8843-8844 | -LRB- | denotes | ( |
T20227 | 8838-8842 | NNP | denotes | IFNβ |
T20226 | 8821-8837 | JJ | denotes | adaptor-inducing |
T20225 | 8803-8820 | JJ | denotes | domain-containing |
T20224 | 8799-8802 | NNP | denotes | TIR |
T20223 | 8797-8798 | , | denotes | , |
T20222 | 8794-8797 | NNP | denotes | MAL |
T20221 | 8792-8793 | , | denotes | , |
T20220 | 8787-8792 | NNP | denotes | MyD88 |
T20219 | 8785-8786 | , | denotes | , |
T20218 | 8784-8785 | -RRB- | denotes | ) |
T20217 | 8779-8784 | NNP | denotes | TRADD |
T20216 | 8778-8779 | -LRB- | denotes | ( |
T20215 | 8770-8777 | NN | denotes | protein |
T20214 | 8763-8769 | NN | denotes | domain |
T20213 | 8757-8762 | NN | denotes | death |
T20212 | 8744-8756 | JJ | denotes | 1-associated |
T20211 | 8735-8743 | NN | denotes | receptor |
T20210 | 8731-8734 | NN | denotes | TNF |
T20209 | 8730-8731 | -LRB- | denotes | ( |
T20208 | 8721-8729 | NNS | denotes | proteins |
T20207 | 8713-8720 | NN | denotes | adaptor |
T20206 | 8704-8712 | JJ | denotes | specific |
T20205 | 8701-8703 | IN | denotes | of |
T20204 | 8689-8700 | NN | denotes | recruitment |
T20203 | 8685-8688 | DT | denotes | the |
T20202 | 8677-8684 | NN | denotes | trigger |
T20201 | 8672-8676 | CD | denotes | TLR4 |
T20200 | 8668-8671 | CC | denotes | and |
T20199 | 8666-8667 | , | denotes | , |
T20198 | 8662-8666 | NNP | denotes | RANK |
T20197 | 8660-8661 | , | denotes | , |
T20196 | 8656-8660 | NNP | denotes | CD40 |
T20195 | 8654-8655 | , | denotes | , |
T20194 | 8649-8654 | CD | denotes | TNFR1 |
T20193 | 8646-8648 | IN | denotes | as |
T20192 | 8641-8645 | JJ | denotes | such |
T20191 | 8631-8640 | NNS | denotes | receptors |
T20190 | 8622-8630 | NN | denotes | membrane |
T20189 | 8613-8621 | JJ | denotes | specific |
T20458 | 10176-10181 | JJ | denotes | NF-κB |
T20457 | 10173-10175 | IN | denotes | of |
T20456 | 10162-10172 | NN | denotes | regulation |
T20455 | 10153-10161 | NN | denotes | feedback |
T20454 | 10144-10152 | JJ | denotes | negative |
T20453 | 10140-10143 | DT | denotes | the |
T20452 | 10137-10139 | IN | denotes | in |
T20451 | 10132-10136 | PRP | denotes | them |
T20450 | 10120-10131 | VBG | denotes | implicating |
T20449 | 10118-10119 | , | denotes | , |
T20448 | 10109-10118 | JJ | denotes | dependent |
T20447 | 10103-10108 | JJ | denotes | NF-κB |
T20446 | 10100-10102 | VBZ | denotes | is |
T20445 | 10090-10099 | NNS | denotes | molecules |
T20444 | 10079-10089 | JJ | denotes | regulatory |
T20443 | 10070-10078 | JJ | denotes | negative |
T20442 | 10064-10069 | DT | denotes | these |
T20441 | 10061-10063 | IN | denotes | of |
T20440 | 10056-10060 | JJ | denotes | many |
T20439 | 10053-10055 | IN | denotes | of |
T20438 | 10042-10052 | NN | denotes | expression |
T20437 | 10038-10041 | DT | denotes | The |
T20436 | 10036-10037 | . | denotes | . |
T20435 | 10031-10036 | NNP | denotes | TRAF6 |
T20434 | 10027-10030 | CC | denotes | and |
T20433 | 10021-10026 | NNP | denotes | IRAK1 |
T20432 | 10018-10020 | TO | denotes | to |
T20431 | 10010-10017 | JJ | denotes | binding |
T20430 | 10006-10009 | IN | denotes | for |
T20429 | 10001-10005 | CD | denotes | TLR4 |
T20428 | 9996-10000 | IN | denotes | with |
T20427 | 9988-9995 | VB | denotes | compete |
T20426 | 9985-9987 | TO | denotes | to |
T20425 | 9976-9984 | VBN | denotes | proposed |
T20424 | 9971-9975 | VBN | denotes | been |
T20423 | 9967-9970 | VBZ | denotes | has |
T20422 | 9961-9966 | WDT | denotes | which |
T20421 | 9959-9960 | , | denotes | , |
T20420 | 9953-9959 | NNP | denotes | SIGIRR |
T20419 | 9945-9952 | NN | denotes | protein |
T20418 | 9931-9944 | NN | denotes | transmembrane |
T20417 | 9927-9930 | DT | denotes | the |
T20416 | 9924-9926 | IN | denotes | by |
T20415 | 9914-9923 | VBN | denotes | inhibited |
T20414 | 9911-9913 | VB | denotes | be |
T20413 | 9906-9910 | RB | denotes | also |
T20412 | 9902-9905 | MD | denotes | can |
T20411 | 9891-9901 | NN | denotes | signalling |
T20410 | 9887-9890 | NNP | denotes | TLR |
T20409 | 9885-9886 | , | denotes | , |
T20408 | 9878-9885 | RB | denotes | Finally |
T20407 | 9876-9877 | . | denotes | . |
T20406 | 9871-9876 | NNP | denotes | TRAF6 |
T20405 | 9867-9870 | CC | denotes | and |
T20188 | 8610-8612 | IN | denotes | of |
T20187 | 8599-8609 | NN | denotes | engagement |
T20186 | 8592-8598 | NNP | denotes | Ligand |
T20185 | 8590-8591 | . | denotes | . |
T20184 | 8580-8590 | NNS | denotes | regulators |
T20183 | 8571-8579 | JJ | denotes | negative |
T20182 | 8567-8570 | CC | denotes | and |
T20181 | 8556-8566 | VBG | denotes | signalling |
T20180 | 8550-8555 | NNP | denotes | NF-κB |
T20179 | 8540-8549 | NNP | denotes | Canonical |
T19188 | 33648-33650 | NNP | denotes | RA |
T19187 | 33645-33647 | IN | denotes | as |
T19186 | 33640-33644 | JJ | denotes | such |
T19185 | 33631-33639 | NNS | denotes | diseases |
T19184 | 33618-33630 | JJ | denotes | inflammatory |
T19183 | 33614-33617 | IN | denotes | for |
T19182 | 33603-33613 | NNS | denotes | treatments |
T19181 | 33599-33602 | JJ | denotes | new |
T19180 | 33596-33598 | TO | denotes | to |
T19179 | 33591-33595 | VB | denotes | lead |
T19178 | 33587-33590 | MD | denotes | may |
T19177 | 33577-33586 | NN | denotes | knowledge |
T19176 | 33572-33576 | DT | denotes | this |
T19175 | 33568-33571 | WRB | denotes | how |
T19174 | 33566-33567 | , | denotes | , |
T19173 | 33555-33566 | RB | denotes | importantly |
T19172 | 33550-33554 | RBR | denotes | more |
T19171 | 33548-33549 | , | denotes | , |
T19170 | 33545-33548 | CC | denotes | and |
T19169 | 33543-33544 | , | denotes | , |
T19168 | 33534-33543 | VBN | denotes | organised |
T19167 | 33531-33533 | VBZ | denotes | is |
T19166 | 33520-33530 | NN | denotes | signalling |
T19165 | 33514-33519 | JJ | denotes | NF-κB |
T19164 | 33510-33513 | WRB | denotes | how |
T19163 | 33502-33509 | VB | denotes | clarify |
T19162 | 33499-33501 | TO | denotes | to |
T19161 | 33493-33498 | NN | denotes | order |
T19160 | 33490-33492 | IN | denotes | in |
T19159 | 33481-33489 | NN | denotes | question |
T19158 | 33471-33480 | JJ | denotes | important |
T19157 | 33468-33470 | DT | denotes | an |
T19156 | 33465-33467 | VB | denotes | be |
T19155 | 33460-33464 | MD | denotes | will |
T19154 | 33450-33459 | VBN | denotes | regulated |
T19153 | 33439-33449 | PRP | denotes | themselves |
T19152 | 33435-33438 | VBP | denotes | are |
T19151 | 33427-33434 | NNS | denotes | signals |
T19150 | 33416-33426 | JJ | denotes | regulatory |
T19149 | 33410-33415 | DT | denotes | these |
T19148 | 33406-33409 | PDT | denotes | all |
T19147 | 33402-33405 | WRB | denotes | How |
T19146 | 33400-33401 | . | denotes | . |
T19145 | 33392-33400 | VBN | denotes | expected |
T19144 | 33389-33391 | VB | denotes | be |
T19143 | 33385-33388 | MD | denotes | can |
T19142 | 33374-33384 | NN | denotes | complexity |
T19141 | 33366-33373 | JJ | denotes | intense |
T19140 | 33364-33365 | , | denotes | , |
T19139 | 33358-33364 | VBP | denotes | target |
T19138 | 33353-33357 | PRP | denotes | they |
T19137 | 33347-33352 | NNS | denotes | mRNAs |
T19136 | 33338-33346 | JJ | denotes | multiple |
T19135 | 33334-33337 | DT | denotes | the |
T19134 | 33330-33333 | CC | denotes | and |
T19133 | 33323-33329 | NNS | denotes | humans |
T19132 | 33320-33322 | IN | denotes | in |
T19131 | 33313-33319 | NNS | denotes | miRNAs |
T19130 | 33310-33312 | IN | denotes | of |
T19129 | 33303-33309 | NN | denotes | number |
T19128 | 33299-33302 | DT | denotes | the |
T19127 | 33293-33298 | VBN | denotes | given |
T19126 | 33291-33292 | , | denotes | , |
T19125 | 33283-33291 | NN | denotes | addition |
T19124 | 33280-33282 | IN | denotes | In |
T19123 | 33278-33279 | . | denotes | . |
T19122 | 33274-33278 | PRP | denotes | them |
T19121 | 33266-33273 | IN | denotes | between |
T19120 | 33253-33265 | NN | denotes | relationship |
T19119 | 33249-33252 | DT | denotes | the |
T19118 | 33245-33248 | CC | denotes | and |
T19117 | 33234-33244 | NNS | denotes | regulators |
T19116 | 33228-33233 | DT | denotes | these |
T19115 | 33225-33227 | IN | denotes | of |
T19114 | 33220-33224 | DT | denotes | each |
T19113 | 33217-33219 | IN | denotes | of |
T19112 | 33212-33216 | NN | denotes | role |
T19111 | 33203-33211 | JJ | denotes | specific |
T19110 | 33199-33202 | DT | denotes | the |
T19109 | 33196-33198 | IN | denotes | of |
T19108 | 33187-33195 | NN | denotes | question |
T19107 | 33183-33186 | DT | denotes | the |
T19106 | 33176-33182 | VBZ | denotes | raises |
T19105 | 33174-33175 | , | denotes | , |
T19104 | 33167-33174 | RB | denotes | however |
T19103 | 33165-33166 | , | denotes | , |
T19102 | 33158-33165 | NN | denotes | pathway |
T19101 | 33152-33157 | NNP | denotes | NF-κB |
T19100 | 33148-33151 | DT | denotes | the |
T19099 | 33145-33147 | IN | denotes | of |
T19098 | 33134-33144 | NN | denotes | regulation |
T19097 | 33128-33133 | JJ | denotes | tight |
T19096 | 33126-33127 | DT | denotes | a |
T19095 | 33117-33125 | VBG | denotes | ensuring |
T19094 | 33106-33116 | NNS | denotes | regulators |
T19093 | 33097-33105 | JJ | denotes | negative |
T19092 | 33088-33096 | JJ | denotes | multiple |
T19091 | 33085-33087 | IN | denotes | of |
T19090 | 33075-33084 | NN | denotes | existence |
T19089 | 33071-33074 | DT | denotes | The |
T19088 | 33069-33070 | . | denotes | . |
T19087 | 33057-33069 | NNS | denotes | therapeutics |
T19086 | 33048-33056 | JJ | denotes | specific |
T19085 | 33045-33047 | IN | denotes | of |
T19084 | 33038-33044 | NN | denotes | design |
T19083 | 33034-33037 | DT | denotes | the |
T19082 | 33030-33033 | IN | denotes | for |
T19081 | 33020-33029 | JJ | denotes | important |
T19080 | 33015-33019 | RB | denotes | very |
T19079 | 33012-33014 | VB | denotes | be |
T19078 | 33007-33011 | RB | denotes | thus |
T19077 | 33003-33006 | MD | denotes | can |
T19076 | 32995-33002 | NN | denotes | control |
T19075 | 32989-32994 | IN | denotes | under |
T19074 | 32978-32988 | NN | denotes | activation |
T19073 | 32972-32977 | JJ | denotes | NF-κB |
T19072 | 32964-32971 | VBG | denotes | Keeping |
T19071 | 32962-32963 | . | denotes | . |
T19070 | 32951-32962 | NN | denotes | destruction |
T19069 | 32946-32950 | NN | denotes | bone |
T19068 | 32942-32945 | CC | denotes | and |
T19067 | 32932-32941 | NN | denotes | cartilage |
T19066 | 32929-32931 | TO | denotes | to |
T19065 | 32921-32928 | VBG | denotes | leading |
T19064 | 32918-32920 | NNP | denotes | RA |
T19063 | 32915-32917 | IN | denotes | in |
T19062 | 32905-32914 | NNS | denotes | processes |
T19061 | 32892-32904 | JJ | denotes | inflammatory |
T19060 | 32888-32891 | DT | denotes | the |
T19059 | 32885-32887 | IN | denotes | in |
T19058 | 32879-32884 | NNS | denotes | roles |
T19057 | 32871-32878 | JJ | denotes | crucial |
T19056 | 32865-32870 | VBZ | denotes | plays |
T19055 | 32857-32864 | NNS | denotes | factors |
T19054 | 32843-32856 | NN | denotes | transcription |
T19053 | 32840-32842 | IN | denotes | of |
T19052 | 32833-32839 | NN | denotes | family |
T19051 | 32827-32832 | NNP | denotes | NF-κB |
T19050 | 32823-32826 | DT | denotes | The |
T19189 | 33650-33651 | . | denotes | . |
T18500 | 32808-32809 | . | denotes | . |
T18499 | 32807-32808 | NNP | denotes | ] |
T18498 | 32799-32807 | CD | denotes | 83,88,91 |
T18497 | 32798-32799 | NNP | denotes | [ |
T18496 | 32785-32797 | NN | denotes | pathogenesis |
T18495 | 32781-32784 | IN | denotes | for |
T18494 | 32770-32780 | NNS | denotes | biomarkers |
T18493 | 32759-32769 | JJ | denotes | diagnostic |
T18492 | 32756-32758 | IN | denotes | as |
T18491 | 32746-32755 | JJ | denotes | potential |
T18490 | 32740-32745 | PRP$ | denotes | their |
T18489 | 32729-32739 | VBG | denotes | indicating |
T18488 | 32727-32728 | , | denotes | , |
T18487 | 32719-32727 | NNS | denotes | patients |
T18486 | 32716-32718 | NNP | denotes | RA |
T18485 | 32713-32715 | IN | denotes | in |
T18484 | 32702-32712 | NN | denotes | expression |
T18483 | 32694-32701 | JJ | denotes | altered |
T18482 | 32691-32693 | DT | denotes | an |
T18481 | 32686-32690 | VB | denotes | have |
T18480 | 32683-32685 | TO | denotes | to |
T18479 | 32677-32682 | VBN | denotes | shown |
T18478 | 32672-32676 | RB | denotes | also |
T18477 | 32667-32671 | VBD | denotes | were |
T18476 | 32659-32666 | JJ | denotes | miR-223 |
T18475 | 32655-32658 | CC | denotes | and |
T18474 | 32653-32654 | , | denotes | , |
T18473 | 32646-32653 | NNP | denotes | miR-132 |
T18472 | 32644-32645 | , | denotes | , |
T18471 | 32638-32644 | NNP | denotes | miR-16 |
T18470 | 32636-32637 | , | denotes | , |
T18469 | 32629-32636 | RB | denotes | Finally |
T18468 | 32627-32628 | . | denotes | . |
T18467 | 32626-32627 | NNP | denotes | ] |
T18466 | 32624-32626 | CD | denotes | 90 |
T18465 | 32623-32624 | NNP | denotes | [ |
T18464 | 32611-32622 | NNS | denotes | fibroblasts |
T18463 | 32602-32610 | JJ | denotes | synovial |
T18462 | 32599-32601 | NNP | denotes | RA |
T18461 | 32596-32598 | IN | denotes | in |
T18460 | 32587-32595 | VBN | denotes | detected |
T18459 | 32582-32586 | VBD | denotes | were |
T18458 | 32580-32581 | : | denotes | - |
T18457 | 32575-32579 | NN | denotes | IL-6 |
T18456 | 32571-32574 | CC | denotes | and |
T18455 | 32551-32570 | NN | denotes | metalloproteinase-1 |
T18454 | 32544-32550 | NN | denotes | matrix |
T18453 | 32541-32543 | IN | denotes | of |
T18452 | 32531-32540 | NN | denotes | secretion |
T18451 | 32521-32530 | VBN | denotes | increased |
T18450 | 32518-32520 | TO | denotes | to |
T18449 | 32510-32517 | VBG | denotes | leading |
T18448 | 32508-32509 | : | denotes | - |
T18447 | 32500-32507 | NN | denotes | miR-203 |
T18446 | 32497-32499 | IN | denotes | of |
T18445 | 32490-32496 | NNS | denotes | levels |
T18444 | 32481-32489 | JJ | denotes | elevated |
T18443 | 32479-32480 | , | denotes | , |
T18442 | 32470-32479 | RB | denotes | Similarly |
T18441 | 32468-32469 | . | denotes | . |
T18440 | 32467-32468 | NNP | denotes | ] |
T18439 | 32465-32467 | CD | denotes | 89 |
T18438 | 32464-32465 | NNP | denotes | [ |
T18437 | 32455-32463 | NNS | denotes | patients |
T18436 | 32452-32454 | NNP | denotes | RA |
T18435 | 32447-32451 | IN | denotes | from |
T18434 | 32434-32446 | NNS | denotes | synoviocytes |
T18433 | 32431-32433 | IN | denotes | in |
T18432 | 32421-32430 | VBN | denotes | decreased |
T18431 | 32418-32420 | VB | denotes | be |
T18430 | 32415-32417 | TO | denotes | to |
T18429 | 32409-32414 | VBN | denotes | shown |
T18428 | 32405-32408 | VBD | denotes | was |
T18427 | 32403-32404 | : | denotes | - |
T18426 | 32401-32402 | LS | denotes | 1 |
T18425 | 32393-32400 | NN | denotes | protein |
T18386 | 32152-32159 | NNP | denotes | miR-155 |
T18385 | 32148-32151 | CC | denotes | and |
T18384 | 32140-32147 | NNP | denotes | miR-146 |
T18383 | 32132-32139 | IN | denotes | Besides |
T18382 | 32130-32131 | . | denotes | . |
T18381 | 32124-32130 | NN | denotes | cohort |
T18380 | 32111-32123 | JJ | denotes | well-defined |
T18379 | 32107-32110 | CC | denotes | and |
T18378 | 32101-32106 | JJ | denotes | large |
T18377 | 32099-32100 | DT | denotes | a |
T18376 | 32093-32098 | VBG | denotes | using |
T18375 | 32080-32092 | NN | denotes | confirmation |
T18374 | 32072-32079 | VB | denotes | require |
T18373 | 32067-32071 | MD | denotes | will |
T18372 | 32062-32066 | DT | denotes | this |
T18371 | 32058-32061 | CC | denotes | but |
T18370 | 32056-32057 | , | denotes | , |
T18369 | 32055-32056 | NNP | denotes | ] |
T18368 | 32053-32055 | CD | denotes | 88 |
T18367 | 32052-32053 | NNP | denotes | [ |
T18366 | 32043-32051 | NN | denotes | efficacy |
T18365 | 32033-32042 | NN | denotes | treatment |
T18364 | 32030-32032 | CC | denotes | or |
T18363 | 32028-32029 | , | denotes | , |
T18362 | 32017-32028 | NN | denotes | progression |
T18361 | 32015-32016 | , | denotes | , |
T18360 | 32006-32015 | NN | denotes | diagnosis |
T18359 | 31998-32005 | NN | denotes | disease |
T18358 | 31994-31997 | IN | denotes | for |
T18357 | 31987-31993 | NN | denotes | marker |
T18356 | 31985-31986 | DT | denotes | a |
T18355 | 31982-31984 | IN | denotes | as |
T18354 | 31975-31981 | JJ | denotes | useful |
T18353 | 31963-31974 | RB | denotes | potentially |
T18352 | 31960-31962 | VBZ | denotes | is |
T18351 | 31951-31959 | NNS | denotes | patients |
T18350 | 31948-31950 | NNP | denotes | RA |
T18349 | 31945-31947 | IN | denotes | in |
T18348 | 31934-31944 | NN | denotes | expression |
T18347 | 31924-31933 | VBN | denotes | increased |
T18346 | 31918-31923 | PRP$ | denotes | their |
T18345 | 31916-31917 | , | denotes | , |
T18344 | 31908-31916 | NN | denotes | addition |
T18343 | 31905-31907 | IN | denotes | In |
T18342 | 31903-31904 | . | denotes | . |
T18341 | 31892-31903 | JJ | denotes | substantial |
T18340 | 31889-31891 | VBZ | denotes | is |
T18339 | 31878-31888 | NNS | denotes | treatments |
T18338 | 31874-31877 | JJ | denotes | new |
T18337 | 31871-31873 | IN | denotes | of |
T18336 | 31859-31870 | NN | denotes | development |
T18335 | 31855-31858 | DT | denotes | the |
T18334 | 31851-31854 | IN | denotes | for |
T18333 | 31841-31850 | NN | denotes | potential |
T18332 | 31835-31840 | PRP$ | denotes | their |
T18331 | 31831-31834 | CC | denotes | and |
T18330 | 31828-31830 | NNP | denotes | RA |
T18329 | 31825-31827 | IN | denotes | in |
T18328 | 31812-31824 | NN | denotes | inflammation |
T18327 | 31809-31811 | IN | denotes | of |
T18326 | 31798-31808 | NNS | denotes | regulators |
T18325 | 31789-31797 | JJ | denotes | negative |
T18324 | 31779-31788 | JJ | denotes | important |
T18323 | 31776-31778 | VB | denotes | be |
T18322 | 31766-31775 | RB | denotes | therefore |
T18321 | 31762-31765 | MD | denotes | may |
T18320 | 31754-31761 | NN | denotes | miR-155 |
T18319 | 31750-31753 | CC | denotes | and |
T18318 | 31742-31749 | NN | denotes | miR-146 |
T18317 | 31740-31741 | . | denotes | . |
T18316 | 31739-31740 | NNP | denotes | ] |
T18315 | 31737-31739 | CD | denotes | 87 |
T18314 | 31736-31737 | NNP | denotes | [ |
T18313 | 31733-31735 | NNP | denotes | RA |
T18312 | 31730-31732 | IN | denotes | of |
T18311 | 31717-31729 | NN | denotes | pathogenesis |
T18310 | 31713-31716 | DT | denotes | the |
T18309 | 31710-31712 | IN | denotes | in |
T18308 | 31702-31709 | NN | denotes | process |
T18307 | 31698-31701 | JJ | denotes | key |
T18306 | 31696-31697 | DT | denotes | a |
T18305 | 31694-31695 | , | denotes | , |
T18304 | 31684-31694 | NN | denotes | production |
T18303 | 31680-31683 | NNP | denotes | TNF |
T18302 | 31672-31679 | VB | denotes | promote |
T18301 | 31669-31671 | TO | denotes | to |
T18300 | 31663-31668 | VBN | denotes | shown |
T18299 | 31659-31662 | VBD | denotes | was |
T18298 | 31651-31658 | NN | denotes | miR-155 |
T18297 | 31649-31650 | , | denotes | , |
T18296 | 31641-31649 | RB | denotes | Moreover |
T18295 | 31639-31640 | . | denotes | . |
T18294 | 31638-31639 | NNP | denotes | ] |
T18293 | 31636-31638 | CD | denotes | 81 |
T18292 | 31635-31636 | NNP | denotes | [ |
T18278 | 31521-31524 | NNP | denotes | TLR |
T18277 | 31517-31520 | DT | denotes | the |
T18276 | 31509-31516 | VB | denotes | prevent |
T18275 | 31506-31508 | TO | denotes | to |
T18274 | 31501-31505 | JJ | denotes | able |
T18273 | 31497-31500 | VBD | denotes | was |
T18272 | 31485-31496 | NNS | denotes | fibroblasts |
T18271 | 31476-31484 | JJ | denotes | synovial |
T18270 | 31473-31475 | IN | denotes | in |
T18269 | 31458-31472 | NN | denotes | overexpression |
T18268 | 31450-31457 | NN | denotes | miR-155 |
T18267 | 31448-31449 | . | denotes | . |
T18266 | 31447-31448 | NNP | denotes | ] |
T18265 | 31445-31447 | CD | denotes | 86 |
T18264 | 31444-31445 | NNP | denotes | [ |
T18263 | 31429-31443 | NN | denotes | susceptibility |
T18262 | 31426-31428 | NNP | denotes | RA |
T18261 | 31421-31425 | IN | denotes | with |
T18260 | 31410-31420 | VBN | denotes | associated |
T18259 | 31407-31409 | VB | denotes | be |
T18258 | 31404-31406 | TO | denotes | to |
T18257 | 31398-31403 | VBN | denotes | shown |
T18256 | 31389-31397 | RB | denotes | recently |
T18255 | 31385-31388 | VBD | denotes | was |
T18254 | 31380-31384 | NN | denotes | gene |
T18253 | 31373-31379 | NN | denotes | target |
T18252 | 31364-31372 | NN | denotes | miR-146a |
T18251 | 31360-31363 | DT | denotes | the |
T18250 | 31357-31359 | IN | denotes | of |
T18249 | 31353-31356 | NNP | denotes | UTR |
T18248 | 31352-31353 | : | denotes | - |
T18247 | 31351-31352 | '' | denotes | ' |
T18246 | 31350-31351 | CD | denotes | 3 |
T18245 | 31346-31349 | DT | denotes | the |
T18244 | 31343-31345 | IN | denotes | in |
T18243 | 31330-31342 | NN | denotes | polymorphism |
T18242 | 31328-31329 | DT | denotes | a |
T18241 | 31326-31327 | , | denotes | , |
T18240 | 31313-31326 | RB | denotes | Interestingly |
T18239 | 31311-31312 | . | denotes | . |
T18238 | 31310-31311 | NNP | denotes | ] |
T18237 | 31305-31310 | CD | denotes | 84,85 |
T18236 | 31304-31305 | NNP | denotes | [ |
T18235 | 31295-31303 | NNS | denotes | patients |
T18234 | 31292-31294 | NNP | denotes | RA |
T18206 | 31148-31149 | , | denotes | , |
T18205 | 31147-31148 | NNP | denotes | ] |
T18204 | 31142-31147 | CD | denotes | 81,82 |
T18203 | 31141-31142 | NNP | denotes | [ |
T18202 | 31134-31140 | NN | denotes | tissue |
T18201 | 31125-31133 | JJ | denotes | synovial |
T18200 | 31121-31124 | CC | denotes | and |
T18199 | 31109-31120 | NNS | denotes | fibroblasts |
T18198 | 31100-31108 | JJ | denotes | synovial |
T18197 | 31097-31099 | NNP | denotes | RA |
T18196 | 31094-31096 | IN | denotes | in |
T18195 | 31087-31093 | NNS | denotes | levels |
T18194 | 31080-31086 | JJR | denotes | higher |
T18193 | 31077-31079 | IN | denotes | at |
T18192 | 31067-31076 | VBN | denotes | expressed |
T18191 | 31063-31066 | VBP | denotes | are |
T18190 | 31055-31062 | NNP | denotes | miR-155 |
T18189 | 31051-31054 | CC | denotes | and |
T18188 | 31043-31050 | NNP | denotes | miR-146 |
T18187 | 31038-31042 | DT | denotes | both |
T18186 | 31036-31037 | , | denotes | , |
T18185 | 31029-31036 | RB | denotes | Notably |
T18184 | 31027-31028 | . | denotes | . |
T18183 | 31026-31027 | NNP | denotes | ] |
T18182 | 31021-31026 | CD | denotes | 79,80 |
T18181 | 31020-31021 | NNP | denotes | [ |
T18180 | 31015-31019 | NNP | denotes | RIP1 |
T18179 | 31011-31014 | CC | denotes | and |
T18178 | 31006-31010 | NNP | denotes | IKKε |
T18177 | 30996-31005 | NNS | denotes | molecules |
T18176 | 30985-30995 | VBG | denotes | signalling |
T18175 | 30979-30984 | NN | denotes | NF-κB |
T18174 | 30975-30978 | DT | denotes | the |
T18173 | 30971-30974 | IN | denotes | for |
T18172 | 30959-30970 | NNS | denotes | transcripts |
T18171 | 30952-30958 | VB | denotes | target |
T18424 | 32377-32392 | JJ | denotes | chemoattractant |
T18423 | 32368-32376 | NN | denotes | monocyte |
T18422 | 32358-32367 | NN | denotes | chemokine |
T18421 | 32354-32357 | DT | denotes | the |
T18420 | 32351-32353 | IN | denotes | of |
T18419 | 32341-32350 | NN | denotes | regulator |
T18418 | 32337-32340 | JJ | denotes | key |
T18417 | 32335-32336 | DT | denotes | a |
T18416 | 32333-32334 | : | denotes | - |
T18415 | 32324-32332 | NN | denotes | miR-124a |
T18414 | 32322-32323 | , | denotes | , |
T18413 | 32315-32322 | NN | denotes | context |
T18412 | 32310-32314 | DT | denotes | this |
T18411 | 32307-32309 | IN | denotes | In |
T18410 | 32305-32306 | . | denotes | . |
T18409 | 32295-32305 | VBN | denotes | identified |
T18408 | 32286-32294 | RB | denotes | recently |
T18407 | 32281-32285 | VBD | denotes | were |
T18406 | 32271-32280 | NN | denotes | pathology |
T18405 | 32268-32270 | NNP | denotes | RA |
T18404 | 32265-32267 | IN | denotes | in |
T18403 | 32255-32264 | NNS | denotes | responses |
T18402 | 32242-32254 | JJ | denotes | inflammatory |
T18401 | 32226-32241 | JJ | denotes | NF-κB-dependent |
T18400 | 32223-32225 | IN | denotes | of |
T18399 | 32215-32222 | NN | denotes | control |
T18398 | 32211-32214 | DT | denotes | the |
T18397 | 32208-32210 | IN | denotes | in |
T18396 | 32203-32207 | NN | denotes | role |
T18395 | 32193-32202 | JJ | denotes | potential |
T18394 | 32191-32192 | DT | denotes | a |
T18393 | 32186-32190 | IN | denotes | with |
T18392 | 32179-32185 | NNS | denotes | miRNAs |
T18391 | 32173-32178 | JJ | denotes | other |
T18390 | 32170-32172 | IN | denotes | of |
T18389 | 32163-32169 | NN | denotes | number |
T18388 | 32161-32162 | DT | denotes | a |
T18387 | 32159-32160 | , | denotes | , |
T18170 | 30949-30951 | TO | denotes | to |
T18169 | 30943-30948 | VBN | denotes | shown |
T18168 | 30939-30942 | VBD | denotes | was |
T18167 | 30931-30938 | NN | denotes | miR-155 |
T18166 | 30929-30930 | , | denotes | , |
T18165 | 30920-30929 | RB | denotes | Similarly |
T18164 | 30918-30919 | . | denotes | . |
T18163 | 30917-30918 | -RRB- | denotes | ) |
T18162 | 30916-30917 | CD | denotes | 1 |
T18161 | 30909-30915 | NNP | denotes | Figure |
T18160 | 30908-30909 | -LRB- | denotes | ( |
T18159 | 30906-30907 | NNP | denotes | ] |
T18158 | 30904-30906 | CD | denotes | 78 |
T18157 | 30903-30904 | NNP | denotes | [ |
T18156 | 30894-30902 | JJ | denotes | miR-146a |
T18155 | 30891-30893 | IN | denotes | of |
T18154 | 30885-30890 | NNS | denotes | genes |
T18153 | 30878-30884 | NN | denotes | target |
T18152 | 30875-30877 | IN | denotes | as |
T18151 | 30864-30874 | VBN | denotes | identified |
T18150 | 30859-30863 | VBD | denotes | were |
T18149 | 30853-30858 | NNP | denotes | TRAF6 |
T18148 | 30849-30852 | CC | denotes | and |
T18147 | 30843-30848 | NNP | denotes | IRAK1 |
T18146 | 30833-30842 | NNS | denotes | molecules |
T18145 | 30822-30832 | VBG | denotes | signalling |
T18144 | 30816-30821 | NN | denotes | NF-κB |
T18143 | 30812-30815 | DT | denotes | the |
T18142 | 30808-30811 | CC | denotes | and |
T18141 | 30806-30807 | , | denotes | , |
T18140 | 30802-30806 | NN | denotes | gene |
T18139 | 30786-30801 | JJ | denotes | NF-κB-dependent |
T18138 | 30783-30785 | DT | denotes | an |
T18137 | 30780-30782 | VBZ | denotes | is |
T18136 | 30771-30779 | NN | denotes | miR-146a |
T18135 | 30769-30770 | , | denotes | , |
T18134 | 30761-30769 | NN | denotes | addition |
T18133 | 30758-30760 | IN | denotes | In |
T18132 | 30756-30757 | . | denotes | . |
T18131 | 30755-30756 | NNP | denotes | ] |
T18130 | 30750-30755 | CD | denotes | 78,79 |
T18129 | 30749-30750 | NNP | denotes | [ |
T18128 | 30744-30748 | NNP | denotes | TLRs |
T18127 | 30740-30743 | CC | denotes | and |
T18126 | 30736-30739 | NNP | denotes | TNF |
T18125 | 30734-30735 | , | denotes | , |
T18124 | 30729-30734 | NN | denotes | IL-1β |
T18123 | 30726-30728 | IN | denotes | as |
T18122 | 30721-30725 | JJ | denotes | such |
T18121 | 30713-30720 | NNS | denotes | stimuli |
T18120 | 30700-30712 | JJ | denotes | inflammatory |
T18119 | 30697-30699 | IN | denotes | by |
T18118 | 30689-30696 | VBN | denotes | induced |
T18117 | 30686-30688 | VB | denotes | be |
T18116 | 30682-30685 | MD | denotes | can |
T18115 | 30675-30681 | NNS | denotes | miRNAs |
T18114 | 30669-30674 | DT | denotes | these |
T18113 | 30663-30668 | IN | denotes | since |
T18112 | 30661-30662 | , | denotes | , |
T18111 | 30656-30661 | NNP | denotes | NF-κB |
T18110 | 30653-30655 | TO | denotes | to |
T18109 | 30642-30652 | NN | denotes | signalling |
T18108 | 30629-30641 | JJ | denotes | inflammatory |
T18107 | 30625-30628 | IN | denotes | for |
T18106 | 30616-30624 | NN | denotes | interest |
T18105 | 30605-30615 | JJ | denotes | particular |
T18104 | 30602-30604 | IN | denotes | of |
T18103 | 30598-30601 | VBP | denotes | are |
T18102 | 30590-30597 | NN | denotes | miR-155 |
T18101 | 30586-30589 | CC | denotes | and |
T18100 | 30584-30585 | NN | denotes | b |
T18099 | 30583-30584 | NN | denotes | / |
T18098 | 30575-30583 | JJ | denotes | miR-146a |
T18097 | 30573-30574 | . | denotes | . |
T18096 | 30572-30573 | NNP | denotes | ] |
T18095 | 30570-30572 | CD | denotes | 77 |
T16858 | 29363-29370 | RB | denotes | however |
T16857 | 29361-29362 | , | denotes | , |
T16856 | 29356-29361 | NNS | denotes | cells |
T16855 | 29346-29355 | JJ | denotes | dendritic |
T16854 | 29330-29345 | JJ | denotes | TRAF1-deficient |
T16853 | 29328-29329 | . | denotes | . |
T16852 | 29318-29328 | NN | denotes | activation |
T16851 | 29312-29317 | NN | denotes | NF-κB |
T16850 | 29299-29311 | JJ | denotes | CD40-induced |
T16849 | 29296-29298 | IN | denotes | of |
T16848 | 29286-29295 | NN | denotes | regulator |
T16847 | 29277-29285 | JJ | denotes | negative |
T16846 | 29275-29276 | DT | denotes | a |
T16845 | 29272-29274 | IN | denotes | as |
T16844 | 29262-29271 | NNS | denotes | functions |
T16843 | 29257-29261 | RB | denotes | also |
T16842 | 29251-29256 | CD | denotes | TRAF1 |
T16841 | 29249-29250 | . | denotes | . |
T16840 | 29242-29249 | NN | denotes | pathway |
T16839 | 29231-29241 | VBG | denotes | signalling |
T16838 | 29225-29230 | NN | denotes | NF-κB |
T16837 | 29221-29224 | DT | denotes | the |
T16836 | 29218-29220 | IN | denotes | of |
T16835 | 29207-29217 | NN | denotes | activation |
T16834 | 29203-29206 | CC | denotes | and |
T16833 | 29189-29202 | NN | denotes | proliferation |
T16832 | 29180-29188 | JJ | denotes | enhanced |
T16831 | 29175-29179 | IN | denotes | with |
T16830 | 29173-29174 | , | denotes | , |
T16829 | 29170-29173 | NNP | denotes | TNF |
T16828 | 29167-29169 | TO | denotes | to |
T16827 | 29150-29166 | JJ | denotes | hyper-responsive |
T16826 | 29146-29149 | VBP | denotes | are |
T16825 | 29140-29145 | NNS | denotes | cells |
T16824 | 29138-29139 | NNP | denotes | T |
T16823 | 29122-29137 | JJ | denotes | TRAF1-deficient |
T16822 | 29120-29121 | . | denotes | . |
T16821 | 29110-29120 | NN | denotes | activation |
T16820 | 29104-29109 | NN | denotes | NF-κB |
T16819 | 29092-29103 | JJ | denotes | TNF-induced |
T16818 | 29083-29091 | NNS | denotes | inhibits |
T16817 | 29077-29082 | CD | denotes | TRAF1 |
T16816 | 29074-29076 | IN | denotes | of |
T16815 | 29059-29073 | NN | denotes | overexpression |
T16814 | 29055-29058 | CC | denotes | and |
T16813 | 29051-29054 | NNP | denotes | TNF |
T16812 | 29048-29050 | IN | denotes | by |
T16811 | 29038-29047 | JJ | denotes | inducible |
T16810 | 29035-29037 | VBZ | denotes | is |
T16809 | 29029-29034 | CD | denotes | TRAF1 |
T16808 | 29026-29028 | IN | denotes | of |
T16807 | 29015-29025 | NN | denotes | Expression |
T16806 | 29013-29014 | . | denotes | . |
T16805 | 29012-29013 | NNP | denotes | ] |
T16804 | 29007-29012 | CD | denotes | 71,72 |
T16803 | 29006-29007 | NNP | denotes | [ |
T16802 | 28999-29005 | NN | denotes | manner |
T16801 | 28979-28998 | JJ | denotes | cell-type-dependent |
T16800 | 28977-28978 | DT | denotes | a |
T16799 | 28974-28976 | IN | denotes | in |
T16798 | 28965-28973 | RB | denotes | possibly |
T16797 | 28963-28964 | , | denotes | , |
T16796 | 28954-28963 | NNS | denotes | receptors |
T16795 | 28947-28953 | NN | denotes | family |
T16794 | 28943-28946 | NNP | denotes | TNF |
T16793 | 28935-28942 | JJ | denotes | certain |
T16792 | 28932-28934 | IN | denotes | by |
T16791 | 28921-28931 | NN | denotes | signalling |
T16790 | 28915-28920 | JJ | denotes | NF-κB |
T16789 | 28912-28914 | IN | denotes | of |
T16788 | 28902-28911 | NN | denotes | modulator |
T16787 | 28893-28901 | JJ | denotes | positive |
T16786 | 28891-28892 | DT | denotes | a |
T16785 | 28887-28890 | CC | denotes | and |
T16784 | 28878-28886 | JJ | denotes | negative |
T16783 | 28876-28877 | DT | denotes | a |
T16782 | 28871-28875 | DT | denotes | both |
T16781 | 28868-28870 | IN | denotes | as |
T16780 | 28862-28867 | CD | denotes | TRAF1 |
T16779 | 28858-28861 | IN | denotes | for |
T16778 | 28853-28857 | NN | denotes | role |
T16777 | 28851-28852 | DT | denotes | a |
T16776 | 28843-28850 | VBP | denotes | support |
T16775 | 28838-28842 | NNS | denotes | data |
T16774 | 28825-28837 | VBG | denotes | Accumulating |
T16773 | 28823-28824 | . | denotes | . |
T16772 | 28815-28823 | NN | denotes | activity |
T16771 | 28808-28814 | NN | denotes | ligase |
T16770 | 28798-28807 | NN | denotes | ubiquitin |
T16769 | 28792-28797 | VBZ | denotes | lacks |
T16768 | 28782-28791 | RB | denotes | therefore |
T16767 | 28778-28781 | CC | denotes | and |
T16766 | 28771-28777 | NN | denotes | domain |
T16765 | 28764-28770 | NN | denotes | finger |
T16764 | 28759-28763 | NN | denotes | RING |
T16763 | 28757-28758 | DT | denotes | a |
T16762 | 28751-28756 | VBZ | denotes | lacks |
T16761 | 28748-28750 | PRP | denotes | it |
T16760 | 28740-28747 | IN | denotes | because |
T16759 | 28733-28739 | NN | denotes | family |
T16758 | 28725-28732 | NN | denotes | protein |
T16757 | 28720-28724 | NNP | denotes | TRAF |
T16756 | 28716-28719 | DT | denotes | the |
T16755 | 28713-28715 | IN | denotes | of |
T16754 | 28706-28712 | NN | denotes | member |
T16753 | 28699-28705 | JJ | denotes | unique |
T16752 | 28697-28698 | DT | denotes | a |
T16751 | 28694-28696 | VBZ | denotes | is |
T16750 | 28688-28693 | CD | denotes | TRAF1 |
T16749 | 28686-28687 | CD | denotes | 1 |
T16748 | 28679-28685 | NN | denotes | factor |
T16747 | 28659-28678 | JJ | denotes | receptor-associated |
T16746 | 28655-28658 | NNP | denotes | TNF |
T16975 | 30081-30083 | VB | denotes | be |
T16974 | 30078-30080 | TO | denotes | to |
T16973 | 30071-30077 | JJ | denotes | likely |
T16972 | 30066-30070 | RBR | denotes | more |
T16971 | 30063-30065 | VBZ | denotes | is |
T16970 | 30057-30062 | CD | denotes | TRAF1 |
T16969 | 30052-30056 | IN | denotes | that |
T16968 | 30042-30051 | VBZ | denotes | indicates |
T16967 | 30037-30041 | NN | denotes | work |
T16966 | 30026-30036 | JJ | denotes | Subsequent |
T16965 | 30024-30025 | . | denotes | . |
T16964 | 30023-30024 | NNP | denotes | ] |
T16963 | 30021-30023 | CD | denotes | 74 |
T16962 | 30020-30021 | NNP | denotes | [ |
T16961 | 30014-30019 | VBZ | denotes | locus |
T16960 | 30009-30013 | NN | denotes | risk |
T16959 | 30006-30008 | NNP | denotes | RA |
T16958 | 29996-30005 | JJ | denotes | important |
T16957 | 29993-29995 | DT | denotes | an |
T16956 | 29990-29992 | IN | denotes | as |
T16955 | 29984-29989 | NN | denotes | locus |
T16954 | 29982-29983 | CD | denotes | 5 |
T16953 | 29972-29981 | NN | denotes | component |
T16952 | 29955-29971 | NN | denotes | TRAF1-complement |
T16951 | 29951-29954 | DT | denotes | the |
T16950 | 29948-29950 | IN | denotes | at |
T16949 | 29938-29947 | NN | denotes | variation |
T16948 | 29930-29937 | JJ | denotes | genetic |
T16947 | 29928-29929 | DT | denotes | a |
T16946 | 29917-29927 | VBD | denotes | identified |
T16945 | 29908-29916 | NNS | denotes | controls |
T16944 | 29902-29907 | CD | denotes | 1,800 |
T16943 | 29898-29901 | CC | denotes | and |
T16942 | 29892-29897 | NNS | denotes | cases |
T16941 | 29889-29891 | NNP | denotes | RA |
T16940 | 29867-29888 | JJ | denotes | autoantibody-positive |
T16939 | 29861-29866 | CD | denotes | 1,500 |
T16938 | 29847-29860 | RB | denotes | approximately |
T16937 | 29841-29846 | IN | denotes | among |
T16936 | 29836-29840 | NNS | denotes | SNPs |
T16935 | 29828-29835 | CD | denotes | 300,000 |
T16934 | 29823-29827 | IN | denotes | than |
T16933 | 29818-29822 | JJR | denotes | more |
T16932 | 29808-29817 | VBG | denotes | examining |
T16931 | 29802-29807 | NN | denotes | study |
T16930 | 29790-29801 | NN | denotes | association |
T16929 | 29778-29789 | JJ | denotes | genome-wide |
T16928 | 29776-29777 | DT | denotes | A |
T16927 | 29774-29775 | . | denotes | . |
T16926 | 29773-29774 | NNP | denotes | ] |
T16925 | 29771-29773 | CD | denotes | 73 |
T16924 | 29770-29771 | NNP | denotes | [ |
T16923 | 29761-29769 | VB | denotes | interact |
T16922 | 29750-29760 | RB | denotes | physically |
T16921 | 29746-29749 | MD | denotes | can |
T16920 | 29743-29745 | PRP | denotes | it |
T16919 | 29737-29742 | WDT | denotes | which |
T16918 | 29732-29736 | IN | denotes | with |
T16917 | 29728-29731 | NNP | denotes | A20 |
T16916 | 29720-29727 | VB | denotes | recruit |
T16915 | 29714-29719 | MD | denotes | might |
T16914 | 29708-29713 | NNP | denotes | TRAF1 |
T16913 | 29706-29707 | , | denotes | , |
T16912 | 29693-29706 | RB | denotes | Alternatively |
T16911 | 29691-29692 | . | denotes | . |
T16910 | 29683-29691 | NNS | denotes | proteins |
T16909 | 29672-29682 | JJ | denotes | signalling |
T16908 | 29666-29671 | JJ | denotes | other |
T16907 | 29663-29665 | CC | denotes | or |
T16906 | 29654-29662 | NN | denotes | receptor |
T16905 | 29650-29653 | DT | denotes | the |
T16904 | 29647-29649 | TO | denotes | to |
T16903 | 29639-29646 | JJ | denotes | binding |
T16902 | 29635-29638 | IN | denotes | for |
T16901 | 29627-29634 | NNS | denotes | members |
T16900 | 29620-29626 | NN | denotes | family |
T16899 | 29615-29619 | NNP | denotes | TRAF |
T16898 | 29610-29614 | IN | denotes | with |
T16897 | 29601-29609 | VBZ | denotes | competes |
T16896 | 29595-29600 | CD | denotes | TRAF1 |
T16895 | 29593-29594 | , | denotes | , |
T16894 | 29585-29593 | RB | denotes | probably |
T16893 | 29580-29584 | JJS | denotes | Most |
T16892 | 29578-29579 | . | denotes | . |
T16891 | 29571-29578 | JJ | denotes | unclear |
T16890 | 29565-29570 | RB | denotes | still |
T16889 | 29562-29564 | VBZ | denotes | is |
T16888 | 29551-29561 | NN | denotes | activation |
T16887 | 29548-29550 | NN | denotes | κB |
T16886 | 29546-29547 | : | denotes | - |
T16885 | 29544-29546 | SYM | denotes | NF |
T16884 | 29534-29543 | VBZ | denotes | modulates |
T16883 | 29528-29533 | NNP | denotes | TRAF1 |
T16882 | 29522-29527 | WDT | denotes | which |
T16881 | 29519-29521 | IN | denotes | by |
T16880 | 29509-29518 | NN | denotes | mechanism |
T16879 | 29505-29508 | DT | denotes | The |
T16878 | 29503-29504 | . | denotes | . |
T16877 | 29498-29503 | NNS | denotes | cells |
T16876 | 29492-29497 | DT | denotes | these |
T16875 | 29489-29491 | IN | denotes | in |
T16874 | 29484-29488 | NN | denotes | role |
T16873 | 29473-29483 | JJ | denotes | regulatory |
T16872 | 29464-29472 | JJ | denotes | positive |
T16871 | 29462-29463 | DT | denotes | a |
T16870 | 29451-29461 | VBG | denotes | suggesting |
T16869 | 29449-29450 | , | denotes | , |
T16868 | 29442-29449 | NNS | denotes | factors |
T16867 | 29426-29441 | JJ | denotes | TRAF2-dependent |
T16866 | 29423-29425 | IN | denotes | by |
T16865 | 29411-29422 | NN | denotes | stimulation |
T16864 | 29401-29410 | JJ | denotes | secondary |
T16863 | 29398-29400 | TO | denotes | to |
T16862 | 29388-29397 | NNS | denotes | responses |
T16861 | 29377-29387 | JJ | denotes | attenuated |
T16860 | 29372-29376 | VBP | denotes | show |
T16859 | 29370-29371 | , | denotes | , |
T16027 | 28474-28485 | VB | denotes | investigate |
T16026 | 28471-28473 | TO | denotes | to |
T16025 | 28468-28470 | CC | denotes | or |
T16024 | 28466-28467 | , | denotes | , |
T16023 | 28458-28466 | NNS | denotes | patients |
T16022 | 28450-28457 | NN | denotes | control |
T16021 | 28447-28449 | IN | denotes | in |
T16020 | 28436-28446 | NN | denotes | expression |
T16019 | 28432-28435 | PRP$ | denotes | its |
T16018 | 28427-28431 | IN | denotes | with |
T16017 | 28418-28426 | NNS | denotes | patients |
T16016 | 28415-28417 | NNP | denotes | RA |
T16015 | 28412-28414 | IN | denotes | in |
T16014 | 28405-28411 | NNP | denotes | SIGIRR |
T16013 | 28402-28404 | IN | denotes | of |
T16012 | 28391-28401 | NN | denotes | expression |
T16011 | 28387-28390 | DT | denotes | the |
T16010 | 28379-28386 | VB | denotes | compare |
T16009 | 28376-28378 | TO | denotes | to |
T16008 | 28364-28375 | JJ | denotes | interesting |
T16007 | 28361-28363 | VB | denotes | be |
T16006 | 28356-28360 | MD | denotes | will |
T16005 | 28353-28355 | PRP | denotes | It |
T16004 | 28351-28352 | . | denotes | . |
T16003 | 28350-28351 | NNP | denotes | ] |
T16002 | 28348-28350 | CD | denotes | 70 |
T16001 | 28347-28348 | NNP | denotes | [ |
T16000 | 28340-28346 | NNS | denotes | models |
T15999 | 28334-28339 | NN | denotes | mouse |
T15998 | 28324-28333 | NNS | denotes | arthritis |
T15997 | 28307-28323 | JJ | denotes | collagen-induced |
T15996 | 28304-28306 | IN | denotes | as |
T15995 | 28299-28303 | RB | denotes | well |
T15994 | 28296-28298 | RB | denotes | as |
T15993 | 28294-28295 | , | denotes | , |
T15992 | 28285-28294 | NNS | denotes | arthritis |
T15991 | 28269-28284 | JJ | denotes | zymosan-induced |
T15990 | 28266-28268 | IN | denotes | in |
T15989 | 28258-28265 | NN | denotes | disease |
T15988 | 28251-28257 | JJ | denotes | severe |
T15987 | 28246-28250 | RBR | denotes | more |
T15986 | 28244-28245 | DT | denotes | a |
T15985 | 28234-28243 | VBD | denotes | developed |
T15984 | 28229-28233 | NNS | denotes | mice |
T15983 | 28212-28228 | JJ | denotes | SIGIRR-deficient |
T15982 | 28206-28211 | IN | denotes | since |
T15981 | 28204-28205 | , | denotes | , |
T15980 | 28200-28204 | NN | denotes | vivo |
T15979 | 28197-28199 | IN | denotes | in |
T15978 | 28187-28196 | VBN | denotes | confirmed |
T15977 | 28179-28186 | JJ | denotes | further |
T15976 | 28175-28178 | VBD | denotes | was |
T15975 | 28168-28174 | NNP | denotes | SIGIRR |
T15974 | 28165-28167 | IN | denotes | of |
T15973 | 28156-28164 | NN | denotes | function |
T15972 | 28145-28155 | JJ | denotes | inhibitory |
T15971 | 28140-28144 | DT | denotes | This |
T15970 | 28138-28139 | . | denotes | . |
T15969 | 28133-28138 | NNS | denotes | cells |
T15968 | 28124-28132 | JJ | denotes | synovial |
T15967 | 28121-28123 | NNP | denotes | RA |
T15966 | 28115-28120 | JJ | denotes | human |
T15965 | 28112-28114 | IN | denotes | by |
T15964 | 28102-28111 | NNS | denotes | cytokines |
T15963 | 28089-28101 | JJ | denotes | inflammatory |
T15962 | 28086-28088 | IN | denotes | of |
T15961 | 28078-28085 | NN | denotes | release |
T15960 | 28066-28077 | JJ | denotes | spontaneous |
T15959 | 28062-28065 | DT | denotes | the |
T15958 | 28054-28061 | VB | denotes | inhibit |
T15957 | 28051-28053 | TO | denotes | to |
T15956 | 28045-28050 | VBN | denotes | shown |
T15955 | 28041-28044 | VBD | denotes | was |
T15954 | 28026-28040 | NN | denotes | overexpression |
T15953 | 28019-28025 | NNP | denotes | SIGIRR |
T15952 | 28017-28018 | , | denotes | , |
T15951 | 28009-28017 | RB | denotes | Recently |
T15950 | 28007-28008 | . | denotes | . |
T15949 | 28006-28007 | NNP | denotes | ] |
T15948 | 28001-28006 | CD | denotes | 69,70 |
T15947 | 28000-28001 | NNP | denotes | [ |
T15946 | 27987-27999 | NNS | denotes | macro-phages |
T15945 | 27980-27986 | JJ | denotes | mature |
T15944 | 27977-27979 | IN | denotes | in |
T15943 | 27973-27976 | RB | denotes | not |
T15942 | 27969-27972 | CC | denotes | but |
T15941 | 27967-27968 | , | denotes | , |
T15940 | 27962-27967 | NNS | denotes | cells |
T15939 | 27952-27961 | JJ | denotes | dendritic |
T15938 | 27943-27951 | NN | denotes | immature |
T15937 | 27939-27942 | CC | denotes | and |
T15936 | 27929-27938 | NNS | denotes | monocytes |
T15935 | 27927-27928 | , | denotes | , |
T15934 | 27922-27927 | NNS | denotes | cells |
T15933 | 27911-27921 | JJ | denotes | epithelial |
T15932 | 27908-27910 | IN | denotes | in |
T15931 | 27898-27907 | VBN | denotes | expressed |
T15930 | 27892-27897 | VBG | denotes | being |
T15929 | 27890-27891 | , | denotes | , |
T15928 | 27883-27890 | NN | denotes | pattern |
T15927 | 27872-27882 | NN | denotes | expression |
T15926 | 27861-27871 | VBN | denotes | restricted |
T15925 | 27856-27860 | RB | denotes | very |
T15924 | 27854-27855 | DT | denotes | a |
T15923 | 27850-27853 | VBZ | denotes | has |
T15922 | 27843-27849 | NNP | denotes | SIGIRR |
T15921 | 27841-27842 | . | denotes | . |
T15920 | 27833-27841 | JJ | denotes | unlikely |
T15919 | 27829-27832 | RB | denotes | not |
T15918 | 27826-27828 | VBZ | denotes | is |
T15917 | 27823-27825 | NNP | denotes | RA |
T15916 | 27820-27822 | IN | denotes | in |
T15915 | 27813-27819 | NNP | denotes | SIGIRR |
T15914 | 27809-27812 | IN | denotes | for |
T15913 | 27804-27808 | NN | denotes | role |
T15912 | 27793-27803 | JJ | denotes | regulatory |
T15911 | 27791-27792 | DT | denotes | a |
T15910 | 27789-27790 | , | denotes | , |
T15909 | 27788-27789 | NNP | denotes | ] |
T15908 | 27786-27788 | CD | denotes | 68 |
T15907 | 27785-27786 | NNP | denotes | [ |
T15906 | 27782-27784 | NNP | denotes | RA |
T15905 | 27779-27781 | IN | denotes | in |
T15904 | 27770-27778 | VBD | denotes | observed |
T15903 | 27757-27769 | NN | denotes | inflammation |
T15902 | 27749-27756 | JJ | denotes | chronic |
T15901 | 27745-27748 | DT | denotes | the |
T15900 | 27742-27744 | IN | denotes | in |
T15899 | 27731-27741 | VBG | denotes | signalling |
T15898 | 27727-27730 | NNP | denotes | TLR |
T15897 | 27723-27726 | CC | denotes | and |
T15896 | 27717-27722 | NN | denotes | IL-1R |
T15895 | 27714-27716 | IN | denotes | of |
T15894 | 27709-27713 | NN | denotes | role |
T15893 | 27699-27708 | JJ | denotes | important |
T15892 | 27695-27698 | DT | denotes | the |
T15891 | 27689-27694 | VBN | denotes | Given |
T15890 | 27687-27688 | . | denotes | . |
T15889 | 27686-27687 | -RRB- | denotes | ) |
T15888 | 27685-27686 | CD | denotes | 1 |
T15887 | 27678-27684 | NNP | denotes | Figure |
T15886 | 27677-27678 | -LRB- | denotes | ( |
T15885 | 27675-27676 | NNP | denotes | ] |
T15884 | 27673-27675 | CD | denotes | 67 |
T15883 | 27672-27673 | NNP | denotes | [ |
T15882 | 27666-27671 | NNP | denotes | TRAF6 |
T15881 | 27663-27665 | CC | denotes | or |
T15880 | 27657-27662 | NNP | denotes | IRAK1 |
T15879 | 27655-27656 | , | denotes | , |
T15878 | 27650-27655 | NNP | denotes | MyD88 |
T15877 | 27648-27649 | , | denotes | , |
T15876 | 27639-27648 | NNS | denotes | receptors |
T15875 | 27633-27638 | DT | denotes | these |
T15874 | 27628-27632 | IN | denotes | with |
T15873 | 27616-27627 | NN | denotes | interaction |
T15872 | 27609-27615 | JJ | denotes | direct |
T15871 | 27601-27608 | IN | denotes | through |
T15870 | 27592-27600 | RB | denotes | probably |
T15869 | 27590-27591 | , | denotes | , |
T15868 | 27580-27590 | NN | denotes | signalling |
T15867 | 27576-27579 | NNP | denotes | TLR |
T15866 | 27572-27575 | CC | denotes | and |
T15865 | 27566-27571 | NN | denotes | IL-1R |
T15864 | 27563-27565 | IN | denotes | of |
T15863 | 27553-27562 | NN | denotes | inhibitor |
T15862 | 27550-27552 | DT | denotes | an |
T15861 | 27547-27549 | IN | denotes | as |
T15860 | 27533-27546 | VBN | denotes | characterised |
T15859 | 27521-27532 | RB | denotes | extensively |
T15858 | 27516-27520 | VBN | denotes | been |
T15857 | 27512-27515 | VBZ | denotes | has |
T15856 | 27507-27511 | WDT | denotes | that |
T15855 | 27500-27506 | NN | denotes | family |
T15854 | 27498-27499 | NNP | denotes | R |
T15853 | 27496-27498 | CD | denotes | -1 |
T15852 | 27490-27496 | NNP | denotes | TLR/IL |
T15851 | 27486-27489 | DT | denotes | the |
T15850 | 27483-27485 | IN | denotes | of |
T15849 | 27476-27482 | NN | denotes | member |
T15848 | 27474-27475 | DT | denotes | a |
T15847 | 27471-27473 | VBZ | denotes | is |
T15846 | 27469-27470 | , | denotes | , |
T15845 | 27464-27469 | CD | denotes | TIR-8 |
T15844 | 27461-27463 | IN | denotes | as |
T15843 | 27455-27460 | VBN | denotes | known |
T15842 | 27450-27454 | RB | denotes | also |
T15841 | 27448-27449 | , | denotes | , |
T15840 | 27441-27448 | NN | denotes | protein |
T15839 | 27439-27440 | -RRB- | denotes | ) |
T15838 | 27433-27439 | NNP | denotes | SIGIRR |
T15837 | 27432-27433 | -LRB- | denotes | ( |
T15836 | 27415-27431 | JJ | denotes | receptor-related |
T15835 | 27410-27414 | NNP | denotes | IL-1 |
T15834 | 27388-27409 | NN | denotes | Single-immunoglobulin |
T15833 | 27380-27387 | NN | denotes | protein |
T15832 | 27363-27379 | JJ | denotes | receptor-related |
T15831 | 27358-27362 | NNP | denotes | IL-1 |
T15830 | 27336-27357 | NN | denotes | Single-immunoglobulin |
T16056 | 28652-28653 | . | denotes | . |
T16055 | 28650-28652 | NNP | denotes | RA |
T16054 | 28647-28649 | IN | denotes | in |
T16053 | 28640-28646 | NN | denotes | target |
T16052 | 28628-28639 | JJ | denotes | therapeutic |
T16051 | 28616-28627 | JJ | denotes | interesting |
T16050 | 28613-28615 | DT | denotes | an |
T16049 | 28610-28612 | VB | denotes | be |
T16048 | 28605-28609 | RB | denotes | also |
T16047 | 28601-28604 | MD | denotes | may |
T16046 | 28594-28600 | NNP | denotes | SIGIRR |
T16045 | 28592-28593 | , | denotes | , |
T16044 | 28585-28592 | NN | denotes | pattern |
T16043 | 28574-28584 | NN | denotes | expression |
T16042 | 28563-28573 | VBN | denotes | restricted |
T16041 | 28559-28562 | PRP$ | denotes | its |
T16040 | 28556-28558 | IN | denotes | of |
T16039 | 28548-28555 | IN | denotes | Because |
T16038 | 28546-28547 | . | denotes | . |
T16037 | 28538-28546 | NNS | denotes | patients |
T16036 | 28535-28537 | NNP | denotes | RA |
T16035 | 28532-28534 | IN | denotes | in |
T16034 | 28520-28531 | VBN | denotes | compromised |
T16033 | 28517-28519 | VBZ | denotes | is |
T16032 | 28510-28516 | NNP | denotes | SIGIRR |
T16031 | 28507-28509 | IN | denotes | of |
T16030 | 28498-28506 | NN | denotes | function |
T16029 | 28494-28497 | DT | denotes | the |
T16028 | 28486-28493 | IN | denotes | whether |
T13554 | 24915-24919 | VBP | denotes | show |
T15018 | 27333-27334 | . | denotes | . |
T15017 | 27331-27333 | NNP | denotes | RA |
T15016 | 27328-27330 | IN | denotes | as |
T15015 | 27323-27327 | JJ | denotes | such |
T15014 | 27313-27322 | NNS | denotes | disorders |
T15013 | 27308-27312 | NN | denotes | bone |
T15012 | 27305-27307 | IN | denotes | of |
T15011 | 27295-27304 | NN | denotes | pathology |
T15010 | 27291-27294 | DT | denotes | the |
T15009 | 27288-27290 | IN | denotes | in |
T15008 | 27279-27287 | VBN | denotes | involved |
T15007 | 27272-27278 | NN | denotes | factor |
T15006 | 27264-27271 | JJ | denotes | genetic |
T15005 | 27254-27263 | JJ | denotes | potential |
T15004 | 27252-27253 | DT | denotes | a |
T15003 | 27249-27251 | IN | denotes | as |
T15002 | 27244-27248 | NNP | denotes | CYLD |
T15001 | 27235-27243 | VBP | denotes | indicate |
T15000 | 27231-27234 | CC | denotes | and |
T14999 | 27212-27230 | NN | denotes | osteoclastogenesis |
T14998 | 27209-27211 | IN | denotes | of |
T14997 | 27198-27208 | NN | denotes | regulation |
T14996 | 27189-27197 | JJ | denotes | negative |
T14995 | 27185-27188 | DT | denotes | the |
T14994 | 27182-27184 | IN | denotes | in |
T14993 | 27177-27181 | NN | denotes | role |
T14992 | 27173-27176 | JJ | denotes | key |
T14991 | 27171-27172 | DT | denotes | a |
T14990 | 27165-27170 | NNS | denotes | plays |
T14989 | 27154-27164 | VBG | denotes | signalling |
T14988 | 27148-27153 | NN | denotes | NF-κB |
T14987 | 27135-27147 | JJ | denotes | RANK-induced |
T14986 | 27132-27134 | IN | denotes | of |
T14985 | 27120-27131 | NN | denotes | inhibi-tion |
T14984 | 27106-27119 | JJ | denotes | CYLD-mediated |
T14983 | 27101-27105 | IN | denotes | that |
T14982 | 27093-27100 | VBP | denotes | suggest |
T14981 | 27084-27092 | NNS | denotes | findings |
T14980 | 27078-27083 | DT | denotes | These |
T14979 | 27076-27077 | . | denotes | . |
T14978 | 27075-27076 | NNP | denotes | ] |
T14977 | 27073-27075 | CD | denotes | 66 |
T14976 | 27072-27073 | NNP | denotes | [ |
T14975 | 27067-27071 | NN | denotes | loss |
T14974 | 27062-27066 | NN | denotes | bone |
T14973 | 27050-27061 | JJ | denotes | progressive |
T14972 | 27042-27049 | VB | denotes | develop |
T14971 | 27038-27041 | CC | denotes | and |
T14970 | 27019-27037 | NN | denotes | osteoclastogenesis |
T14969 | 27010-27018 | JJ | denotes | abnormal |
T14968 | 27002-27009 | NN | denotes | display |
T14967 | 26997-27001 | RB | denotes | also |
T14966 | 26993-26996 | CD | denotes | p62 |
T14965 | 26990-26992 | IN | denotes | of |
T14964 | 26985-26989 | NN | denotes | form |
T14963 | 26977-26984 | VBN | denotes | mutated |
T14962 | 26975-26976 | DT | denotes | a |
T14961 | 26964-26974 | VBG | denotes | expressing |
T14960 | 26959-26963 | NNS | denotes | mice |
T14959 | 26948-26958 | JJ | denotes | transgenic |
T14958 | 26943-26947 | IN | denotes | that |
T14957 | 26932-26942 | VBG | denotes | mentioning |
T14956 | 26926-26931 | JJ | denotes | worth |
T14955 | 26923-26925 | VBZ | denotes | is |
T14954 | 26920-26922 | PRP | denotes | it |
T14953 | 26918-26919 | , | denotes | , |
T14952 | 26911-26918 | NN | denotes | context |
T14951 | 26906-26910 | DT | denotes | this |
T14950 | 26903-26905 | IN | denotes | In |
T14949 | 26901-26902 | . | denotes | . |
T14948 | 26896-26901 | CD | denotes | TRAF6 |
T14947 | 26893-26895 | IN | denotes | of |
T14946 | 26876-26892 | NN | denotes | deubiquitination |
T14945 | 26862-26875 | JJ | denotes | CYLD-mediated |
T14944 | 26858-26861 | DT | denotes | the |
T14943 | 26855-26857 | IN | denotes | by |
T14942 | 26846-26854 | VBN | denotes | followed |
T14941 | 26844-26845 | , | denotes | , |
T14940 | 26843-26844 | NNP | denotes | ] |
T14939 | 26841-26843 | CD | denotes | 65 |
T14938 | 26840-26841 | NNP | denotes | [ |
T14937 | 26838-26839 | -RRB- | denotes | ) |
T14936 | 26837-26838 | CD | denotes | 1 |
T14935 | 26824-26836 | JJ | denotes | sequestosome |
T14934 | 26821-26823 | IN | denotes | as |
T14933 | 26815-26820 | VBN | denotes | known |
T14932 | 26810-26814 | RB | denotes | also |
T14931 | 26809-26810 | -LRB- | denotes | ( |
T14930 | 26805-26808 | NN | denotes | p62 |
T14929 | 26797-26804 | NN | denotes | protein |
T14928 | 26789-26796 | NN | denotes | adaptor |
T14927 | 26771-26788 | JJ | denotes | ubiquitin-binding |
T14926 | 26767-26770 | DT | denotes | the |
T14925 | 26763-26766 | IN | denotes | via |
T14924 | 26757-26762 | CD | denotes | TRAF6 |
T14923 | 26743-26756 | VBN | denotes | ubiquitinated |
T14922 | 26740-26742 | TO | denotes | to |
T14921 | 26730-26739 | VBN | denotes | recruited |
T14920 | 26727-26729 | VBZ | denotes | is |
T14919 | 26723-26726 | CC | denotes | and |
T14918 | 26704-26722 | NN | denotes | osteoclastogenesis |
T14917 | 26690-26703 | JJ | denotes | RANKL-induced |
T14916 | 26687-26689 | IN | denotes | of |
T14915 | 26676-26686 | NNS | denotes | conditions |
T14914 | 26670-26675 | IN | denotes | under |
T14913 | 26658-26669 | VBN | denotes | upregulated |
T14912 | 26649-26657 | RB | denotes | markedly |
T14911 | 26646-26648 | VBZ | denotes | is |
T14910 | 26635-26645 | NN | denotes | expression |
T14909 | 26630-26634 | NNP | denotes | CYLD |
T14908 | 26628-26629 | . | denotes | . |
T14907 | 26617-26628 | NNS | denotes | osteoclasts |
T14906 | 26610-26616 | JJR | denotes | larger |
T14905 | 26606-26609 | CC | denotes | and |
T14904 | 26601-26605 | JJR | denotes | more |
T14903 | 26593-26600 | VB | denotes | produce |
T14902 | 26589-26592 | CC | denotes | and |
T14901 | 26573-26588 | NN | denotes | differentiation |
T14900 | 26559-26572 | JJ | denotes | RANKL-induced |
T14899 | 26556-26558 | TO | denotes | to |
T14898 | 26539-26555 | JJ | denotes | hyper-responsive |
T14897 | 26535-26538 | VBP | denotes | are |
T14896 | 26530-26534 | NNS | denotes | mice |
T14895 | 26524-26529 | DT | denotes | these |
T14894 | 26521-26523 | IN | denotes | of |
T14893 | 26510-26520 | NNS | denotes | precursors |
T14832 | 26133-26134 | , | denotes | , |
T14831 | 26123-26133 | NN | denotes | signalling |
T14830 | 26117-26122 | JJ | denotes | NF-κB |
T14829 | 26114-26116 | IN | denotes | of |
T14828 | 26107-26113 | NNS | denotes | phases |
T14827 | 26101-26106 | RB | denotes | later |
T14826 | 26091-26100 | VBZ | denotes | regulates |
T14825 | 26084-26090 | RB | denotes | mainly |
T14824 | 26076-26083 | NN | denotes | protein |
T14823 | 26071-26075 | DT | denotes | this |
T14822 | 26066-26070 | IN | denotes | that |
T14821 | 26056-26065 | VBN | denotes | suggested |
T14820 | 26051-26055 | VBN | denotes | been |
T14819 | 26047-26050 | VBZ | denotes | has |
T14818 | 26044-26046 | PRP | denotes | it |
T14817 | 26042-26043 | , | denotes | , |
T14816 | 26031-26042 | NN | denotes | stimulation |
T14815 | 26026-26030 | IN | denotes | upon |
T14814 | 26020-26025 | NNS | denotes | types |
T14813 | 26015-26019 | NN | denotes | cell |
T14812 | 26010-26014 | JJ | denotes | many |
T14811 | 26007-26009 | IN | denotes | in |
T14810 | 25997-26006 | VBN | denotes | expressed |
T14809 | 25992-25996 | RB | denotes | only |
T14808 | 25989-25991 | VBZ | denotes | is |
T14807 | 25985-25988 | NNP | denotes | A20 |
T14806 | 25982-25984 | IN | denotes | As |
T14805 | 25980-25981 | . | denotes | . |
T14804 | 25970-25980 | NN | denotes | activation |
T14803 | 25964-25969 | JJ | denotes | NF-κB |
T14802 | 25956-25963 | VB | denotes | control |
T14801 | 25953-25955 | TO | denotes | to |
T14800 | 25948-25952 | NNP | denotes | CYLD |
T14799 | 25945-25947 | IN | denotes | as |
T14798 | 25940-25944 | RB | denotes | well |
T14797 | 25937-25939 | RB | denotes | as |
T14796 | 25933-25936 | NNP | denotes | A20 |
T14795 | 25927-25932 | VBZ | denotes | needs |
T14794 | 25922-25926 | NN | denotes | cell |
T14793 | 25918-25921 | DT | denotes | the |
T14792 | 25914-25917 | WRB | denotes | why |
T14791 | 25908-25913 | JJ | denotes | clear |
T14790 | 25904-25907 | RB | denotes | not |
T14789 | 25898-25903 | RB | denotes | still |
T14788 | 25895-25897 | VBZ | denotes | is |
T14787 | 25892-25894 | PRP | denotes | it |
T14786 | 25888-25891 | CC | denotes | and |
T14785 | 25884-25887 | NNP | denotes | A20 |
T14784 | 25881-25883 | IN | denotes | by |
T14783 | 25872-25880 | VBN | denotes | targeted |
T14782 | 25867-25871 | RB | denotes | also |
T14781 | 25863-25866 | VBP | denotes | are |
T14780 | 25857-25862 | DT | denotes | these |
T14779 | 25854-25856 | IN | denotes | of |
T14778 | 25849-25853 | JJ | denotes | Many |
T14777 | 25847-25848 | . | denotes | . |
T14776 | 25843-25847 | NNP | denotes | TAK1 |
T14775 | 25839-25842 | CC | denotes | and |
T14774 | 25834-25838 | NNP | denotes | RIP1 |
T14773 | 25832-25833 | , | denotes | , |
T14772 | 25827-25832 | NNP | denotes | TRAF7 |
T14771 | 25825-25826 | , | denotes | , |
T14770 | 25820-25825 | NNP | denotes | TRAF6 |
T14769 | 25818-25819 | , | denotes | , |
T14768 | 25813-25818 | NNP | denotes | TRAF2 |
T14767 | 25811-25812 | , | denotes | , |
T14766 | 25807-25811 | NNP | denotes | NEMO |
T14765 | 25797-25806 | VBG | denotes | including |
T14764 | 25788-25796 | NNS | denotes | proteins |
T14763 | 25777-25787 | VBG | denotes | signalling |
T14762 | 25771-25776 | NN | denotes | NF-κB |
T14761 | 25763-25770 | JJ | denotes | several |
T14760 | 25745-25762 | JJ | denotes | deubiquitina-ting |
T14759 | 25742-25744 | IN | denotes | by |
T14758 | 25740-25741 | , | denotes | , |
T14757 | 25739-25740 | -RRB- | denotes | ) |
T14756 | 25738-25739 | CD | denotes | 1 |
T14755 | 25731-25737 | NN | denotes | Figure |
T14754 | 25730-25731 | -LRB- | denotes | ( |
T14753 | 25728-25729 | -RRB- | denotes | ) |
T14752 | 25727-25728 | NNP | denotes | ] |
T14751 | 25725-25727 | CD | denotes | 64 |
T14750 | 25724-25725 | NNP | denotes | [ |
T14749 | 25721-25723 | IN | denotes | in |
T14748 | 25712-25720 | VBN | denotes | reviewed |
T14747 | 25711-25712 | -LRB- | denotes | ( |
T14746 | 25699-25710 | NN | denotes | stimulation |
T14745 | 25690-25698 | NN | denotes | receptor |
T14744 | 25683-25689 | NNP | denotes | T-cell |
T14743 | 25679-25682 | CC | denotes | and |
T14742 | 25674-25678 | NNP | denotes | RANK |
T14741 | 25672-25673 | , | denotes | , |
T14740 | 25668-25672 | NNP | denotes | TNFR |
T14739 | 25665-25667 | IN | denotes | by |
T14738 | 25655-25664 | VBN | denotes | initiated |
T14737 | 25644-25654 | VBG | denotes | signalling |
T14736 | 25638-25643 | JJ | denotes | NF-κB |
T14735 | 25628-25637 | VBZ | denotes | regulates |
T14734 | 25617-25627 | RB | denotes | negatively |
T14733 | 25612-25616 | IN | denotes | that |
T14732 | 25605-25611 | NN | denotes | enzyme |
T14731 | 25588-25604 | VBG | denotes | deubiquitinating |
T14730 | 25586-25587 | DT | denotes | a |
T14729 | 25583-25585 | VBZ | denotes | is |
T14728 | 25578-25582 | NNP | denotes | CYLD |
T14727 | 25576-25577 | . | denotes | . |
T14726 | 25575-25576 | -RRB- | denotes | ) |
T14725 | 25574-25575 | NNP | denotes | ] |
T14724 | 25572-25574 | CD | denotes | 64 |
T14723 | 25571-25572 | NNP | denotes | [ |
T14722 | 25568-25570 | IN | denotes | in |
T14721 | 25559-25567 | VBN | denotes | reviewed |
T14720 | 25558-25559 | -LRB- | denotes | ( |
T14719 | 25539-25557 | NN | denotes | osteoclastogenesis |
T14718 | 25535-25538 | CC | denotes | and |
T14717 | 25533-25534 | , | denotes | , |
T14716 | 25518-25533 | NN | denotes | spermatogenesis |
T14715 | 25516-25517 | , | denotes | , |
T14714 | 25505-25516 | NN | denotes | progression |
T14713 | 25499-25504 | NN | denotes | cycle |
T14712 | 25494-25498 | NN | denotes | cell |
T14711 | 25491-25493 | TO | denotes | to |
T14710 | 25478-25490 | NN | denotes | inflammation |
T14709 | 25474-25477 | CC | denotes | and |
T14708 | 25465-25473 | NN | denotes | immunity |
T14707 | 25460-25464 | IN | denotes | from |
T14706 | 25452-25459 | VBG | denotes | ranging |
T14705 | 25442-25451 | NNS | denotes | processes |
T14704 | 25428-25441 | JJ | denotes | physiological |
T14703 | 25420-25427 | JJ | denotes | diverse |
T14702 | 25417-25419 | IN | denotes | in |
T14701 | 25415-25416 | , | denotes | , |
T14700 | 25408-25415 | RB | denotes | however |
T14699 | 25406-25407 | , | denotes | , |
T14698 | 25398-25406 | VBN | denotes | involved |
T14697 | 25393-25397 | RB | denotes | also |
T14696 | 25390-25392 | VBZ | denotes | is |
T14695 | 25385-25389 | NNP | denotes | CYLD |
T14694 | 25383-25384 | . | denotes | . |
T14693 | 25382-25383 | NNP | denotes | ] |
T14692 | 25380-25382 | CD | denotes | 63 |
T14691 | 25379-25380 | NNP | denotes | [ |
T14690 | 25363-25378 | NN | denotes | cylindromatosis |
T14689 | 25354-25362 | JJ | denotes | familial |
T14688 | 25351-25353 | IN | denotes | in |
T14687 | 25342-25350 | VBN | denotes | involved |
T14686 | 25331-25341 | NN | denotes | suppressor |
T14685 | 25324-25330 | NN | denotes | tumour |
T14684 | 25322-25323 | DT | denotes | a |
T14683 | 25319-25321 | IN | denotes | as |
T14682 | 25308-25318 | VBN | denotes | identified |
T14681 | 25297-25307 | RB | denotes | originally |
T14680 | 25293-25296 | VBD | denotes | was |
T14679 | 25285-25292 | NN | denotes | protein |
T14678 | 25283-25284 | -RRB- | denotes | ) |
T14677 | 25279-25283 | NNP | denotes | CYLD |
T14676 | 25278-25279 | -LRB- | denotes | ( |
T14675 | 25262-25277 | NNP | denotes | Cylindromatosis |
T14674 | 25254-25261 | NN | denotes | protein |
T14673 | 25238-25253 | NNP | denotes | Cylindromatosis |
T14892 | 26499-26509 | NNP | denotes | Osteoclast |
T14891 | 26497-26498 | . | denotes | . |
T14890 | 26485-26497 | NN | denotes | osteoporosis |
T14889 | 26478-26484 | JJ | denotes | severe |
T14888 | 26470-26477 | VB | denotes | develop |
T14887 | 26466-26469 | CC | denotes | and |
T14886 | 26450-26465 | NN | denotes | differentiation |
T14885 | 26439-26449 | NN | denotes | osteoclast |
T14884 | 26430-26438 | JJ | denotes | aberrant |
T14883 | 26425-26429 | VBP | denotes | have |
T14882 | 26420-26424 | NNP | denotes | CYLD |
T14881 | 26417-26419 | IN | denotes | of |
T14880 | 26406-26416 | NN | denotes | deficiency |
T14879 | 26398-26405 | JJ | denotes | genetic |
T14878 | 26396-26397 | DT | denotes | a |
T14877 | 26391-26395 | IN | denotes | with |
T14876 | 26386-26390 | NN | denotes | Mice |
T14875 | 26384-26385 | . | denotes | . |
T14874 | 26383-26384 | NNP | denotes | ] |
T14873 | 26381-26383 | CD | denotes | 65 |
T14872 | 26380-26381 | NNP | denotes | [ |
T14871 | 26375-26379 | NNS | denotes | mice |
T14870 | 26372-26374 | IN | denotes | in |
T14869 | 26353-26371 | NN | denotes | osteoclastogenesis |
T14868 | 26349-26352 | CC | denotes | and |
T14867 | 26338-26348 | NN | denotes | signalling |
T14866 | 26333-26337 | NNP | denotes | RANK |
T14865 | 26324-26332 | VB | denotes | regulate |
T14864 | 26313-26323 | RB | denotes | negatively |
T14863 | 26310-26312 | TO | denotes | to |
T14862 | 26304-26309 | VBN | denotes | shown |
T14861 | 26299-26303 | VBN | denotes | been |
T14860 | 26295-26298 | VBZ | denotes | has |
T14859 | 26290-26294 | NNP | denotes | CYLD |
T14858 | 26288-26289 | , | denotes | , |
T14857 | 26275-26288 | RB | denotes | Interestingly |
T14856 | 26273-26274 | . | denotes | . |
T14855 | 26272-26273 | NNP | denotes | ] |
T14854 | 26270-26272 | CD | denotes | 64 |
T14853 | 26269-26270 | NNP | denotes | [ |
T14852 | 26259-26268 | JJ | denotes | dependent |
T14851 | 26249-26258 | JJ | denotes | cell-type |
T14850 | 26246-26248 | VB | denotes | be |
T14849 | 26241-26245 | RB | denotes | also |
T14848 | 26235-26240 | MD | denotes | might |
T14847 | 26226-26234 | NN | denotes | activity |
T14846 | 26217-26225 | JJ | denotes | relative |
T14845 | 26211-26216 | PRP$ | denotes | their |
T14844 | 26209-26210 | , | denotes | , |
T14843 | 26201-26209 | NN | denotes | addition |
T14842 | 26198-26200 | IN | denotes | In |
T14841 | 26196-26197 | . | denotes | . |
T14840 | 26186-26196 | NN | denotes | signalling |
T14839 | 26180-26185 | JJ | denotes | early |
T14838 | 26176-26179 | CC | denotes | and |
T14837 | 26163-26175 | JJ | denotes | constitutive |
T14836 | 26154-26162 | VB | denotes | regulate |
T14835 | 26148-26153 | MD | denotes | would |
T14834 | 26143-26147 | NNP | denotes | CYLD |
T14833 | 26135-26142 | IN | denotes | whereas |
T13604 | 25235-25236 | . | denotes | . |
T13603 | 25233-25235 | NNP | denotes | RA |
T13602 | 25228-25232 | IN | denotes | with |
T13601 | 25217-25227 | VBN | denotes | associated |
T13600 | 25212-25216 | RB | denotes | also |
T13599 | 25208-25211 | VBP | denotes | are |
T13598 | 25194-25207 | NNS | denotes | erythematosus |
T13597 | 25188-25193 | NN | denotes | lupus |
T13596 | 25179-25187 | JJ | denotes | systemic |
T13595 | 25174-25178 | IN | denotes | with |
T13594 | 25163-25173 | VBN | denotes | associated |
T13593 | 25160-25162 | VB | denotes | be |
T13592 | 25157-25159 | TO | denotes | to |
T13591 | 25148-25156 | VBN | denotes | reported |
T13590 | 25143-25147 | VBN | denotes | been |
T13589 | 25138-25142 | VBP | denotes | have |
T13588 | 25133-25137 | WDT | denotes | that |
T13587 | 25128-25132 | NNS | denotes | SNPs |
T13586 | 25120-25127 | IN | denotes | whether |
T13585 | 25108-25119 | VB | denotes | investigate |
T13584 | 25105-25107 | TO | denotes | to |
T13583 | 25093-25104 | JJ | denotes | interesting |
T13582 | 25090-25092 | VB | denotes | be |
T13581 | 25080-25089 | RB | denotes | therefore |
T13580 | 25075-25079 | MD | denotes | will |
T13579 | 25072-25074 | PRP | denotes | It |
T13578 | 25070-25071 | . | denotes | . |
T13577 | 25069-25070 | -RRB- | denotes | ) |
T13576 | 25060-25069 | NN | denotes | rituximab |
T13575 | 25059-25060 | -LRB- | denotes | ( |
T13574 | 25049-25058 | NN | denotes | depletion |
T13573 | 25042-25048 | NNP | denotes | B-cell |
T13572 | 25039-25041 | IN | denotes | as |
T13571 | 25034-25038 | JJ | denotes | such |
T13570 | 25023-25033 | NNS | denotes | treatments |
T13569 | 25020-25022 | TO | denotes | to |
T13568 | 25011-25019 | NN | denotes | response |
T13567 | 25007-25010 | CC | denotes | and |
T13566 | 24998-25006 | NNS | denotes | features |
T13565 | 24989-24997 | JJ | denotes | systemic |
T13564 | 24987-24988 | , | denotes | , |
T13563 | 24977-24987 | NN | denotes | production |
T13562 | 24964-24976 | JJ | denotes | autoantibody |
T13390 | 23932-23936 | NNS | denotes | mice |
T13389 | 23922-23931 | JJ | denotes | deficient |
T13388 | 23915-23921 | NNP | denotes | ABIN-1 |
T13387 | 23911-23914 | CC | denotes | and |
T13386 | 23909-23910 | , | denotes | , |
T13385 | 23908-23909 | NNP | denotes | ] |
T13384 | 23906-23908 | CD | denotes | 58 |
T13383 | 23905-23906 | NNP | denotes | [ |
T13382 | 23895-23904 | NN | denotes | apoptosis |
T13381 | 23883-23894 | JJ | denotes | TNF-induced |
T13380 | 23874-23882 | VBZ | denotes | inhibits |
T13379 | 23865-23873 | RB | denotes | strongly |
T13378 | 23860-23864 | RB | denotes | also |
T13377 | 23853-23859 | NNP | denotes | ABIN-1 |
T13376 | 23851-23852 | , | denotes | , |
T13375 | 23848-23851 | NNP | denotes | A20 |
T13374 | 23844-23847 | IN | denotes | for |
T13373 | 23841-23843 | IN | denotes | As |
T13372 | 23839-23840 | . | denotes | . |
T13371 | 23838-23839 | NNP | denotes | ] |
T13370 | 23836-23838 | CD | denotes | 57 |
T13369 | 23835-23836 | NNP | denotes | [ |
T13368 | 23828-23834 | NN | denotes | domain |
T13367 | 23810-23827 | JJ | denotes | ubiquitin-binding |
T13366 | 23802-23809 | JJ | denotes | crucial |
T13365 | 23798-23801 | DT | denotes | the |
T13364 | 23790-23797 | VBG | denotes | lacking |
T13363 | 23785-23789 | NN | denotes | form |
T13362 | 23776-23784 | JJ | denotes | inactive |
T13361 | 23772-23775 | CC | denotes | and |
T13360 | 23762-23771 | VBN | denotes | truncated |
T13359 | 23760-23761 | DT | denotes | a |
T13358 | 23752-23759 | VB | denotes | express |
T13357 | 23747-23751 | RB | denotes | only |
T13356 | 23742-23746 | NNS | denotes | mice |
T13355 | 23738-23741 | CC | denotes | but |
T13354 | 23736-23737 | , | denotes | , |
T13353 | 23730-23736 | NNS | denotes | humans |
T13352 | 23727-23729 | IN | denotes | in |
T13351 | 23717-23726 | VBN | denotes | expressed |
T13350 | 23714-23716 | VBZ | denotes | is |
T13349 | 23707-23713 | NNP | denotes | ABIN-3 |
T13348 | 23696-23706 | NNP | denotes | Functional |
T13347 | 23694-23695 | . | denotes | . |
T13346 | 23693-23694 | NNP | denotes | ] |
T13345 | 23688-23693 | CD | denotes | 55,56 |
T13344 | 23687-23688 | NNP | denotes | [ |
T13343 | 23681-23686 | NNP | denotes | ABINs |
T13342 | 23672-23680 | JJ | denotes | multiple |
T13341 | 23669-23671 | IN | denotes | of |
T13340 | 23658-23668 | NNS | denotes | activities |
T13339 | 23647-23657 | NN | denotes | inhibitory |
T13338 | 23641-23646 | NN | denotes | NF-κB |
T13337 | 23631-23640 | JJ | denotes | redundant |
T13336 | 23620-23630 | VBG | denotes | reflecting |
T13335 | 23611-23619 | RB | denotes | possibly |
T13334 | 23609-23610 | , | denotes | , |
T13333 | 23597-23609 | RB | denotes | respectively |
T13332 | 23595-23596 | , | denotes | , |
T13331 | 23586-23595 | NNS | denotes | responses |
T13330 | 23580-23585 | NN | denotes | NF-κB |
T13329 | 23573-23579 | JJ | denotes | normal |
T13328 | 23570-23572 | CC | denotes | or |
T13327 | 23560-23569 | VBN | denotes | increased |
T13326 | 23551-23559 | RB | denotes | slightly |
T13325 | 23546-23550 | RB | denotes | only |
T13324 | 23538-23545 | VBP | denotes | exhibit |
T13323 | 23533-23537 | NNS | denotes | mice |
T13322 | 23516-23532 | JJ | denotes | ABIN-2-deficient |
T13321 | 23512-23515 | CC | denotes | and |
T13320 | 23495-23511 | JJ | denotes | ABIN-1-deficient |
T13319 | 23490-23494 | DT | denotes | both |
T13318 | 23488-23489 | , | denotes | , |
T13317 | 23476-23488 | RB | denotes | Unexpectedly |
T13316 | 23474-23475 | . | denotes | . |
T13315 | 23473-23474 | -RRB- | denotes | ) |
T13314 | 23472-23473 | NNP | denotes | ] |
T13313 | 23470-23472 | CD | denotes | 54 |
T13312 | 23469-23470 | NNP | denotes | [ |
T13311 | 23466-23468 | IN | denotes | in |
T13310 | 23457-23465 | VBN | denotes | reviewed |
T13309 | 23456-23457 | -LRB- | denotes | ( |
T13308 | 23445-23455 | NN | denotes | activation |
T13307 | 23439-23444 | JJ | denotes | NF-κB |
T13306 | 23436-23438 | IN | denotes | of |
T13305 | 23425-23435 | NN | denotes | regulation |
T13304 | 23416-23424 | NN | denotes | feedback |
T13303 | 23407-23415 | JJ | denotes | negative |
T13302 | 23403-23406 | DT | denotes | the |
T13301 | 23400-23402 | IN | denotes | in |
T13300 | 23392-23399 | NN | denotes | complex |
T13299 | 23383-23391 | NNP | denotes | A20/ABIN |
T13298 | 23379-23382 | DT | denotes | the |
T13297 | 23375-23378 | IN | denotes | for |
T13296 | 23370-23374 | NN | denotes | role |
T13295 | 23360-23369 | JJ | denotes | potential |
T13294 | 23358-23359 | DT | denotes | a |
T13293 | 23346-23357 | VBG | denotes | implicating |
T13292 | 23344-23345 | , | denotes | , |
T13291 | 23335-23344 | JJ | denotes | dependent |
T13290 | 23329-23334 | JJ | denotes | NF-κB |
T13289 | 23326-23328 | VBZ | denotes | is |
T13288 | 23315-23325 | NN | denotes | expression |
T13287 | 23308-23314 | NNP | denotes | ABIN-3 |
T13286 | 23304-23307 | CC | denotes | and |
T13285 | 23297-23303 | NNP | denotes | ABIN-1 |
T13284 | 23295-23296 | , | denotes | , |
T13283 | 23292-23295 | NNP | denotes | A20 |
T13282 | 23289-23291 | TO | denotes | to |
T13281 | 23281-23288 | JJ | denotes | Similar |
T13280 | 23279-23280 | . | denotes | . |
T13279 | 23278-23279 | NNP | denotes | ] |
T13278 | 23273-23278 | CD | denotes | 43,44 |
T13277 | 23272-23273 | NNP | denotes | [ |
T13276 | 23261-23271 | NNS | denotes | substrates |
T13275 | 23243-23260 | VBN | denotes | polyubiquitinated |
T13274 | 23240-23242 | TO | denotes | to |
T13273 | 23236-23239 | CD | denotes | A20 |
T13272 | 23229-23235 | VB | denotes | target |
T13271 | 23226-23228 | TO | denotes | to |
T13270 | 23217-23225 | VBN | denotes | proposed |
T13269 | 23212-23216 | VBN | denotes | been |
T13268 | 23207-23211 | VBP | denotes | have |
T13267 | 23202-23206 | PRP | denotes | they |
T13266 | 23200-23201 | , | denotes | , |
T13265 | 23195-23200 | NN | denotes | motif |
T13264 | 23177-23194 | JJ | denotes | ubiquitin-binding |
T13263 | 23168-23176 | JJ | denotes | specific |
T13262 | 23166-23167 | DT | denotes | a |
T13261 | 23158-23165 | VBP | denotes | contain |
T13260 | 23152-23157 | NNP | denotes | ABINs |
T13259 | 23144-23151 | IN | denotes | Because |
T13258 | 23142-23143 | . | denotes | . |
T13257 | 23128-23142 | NN | denotes | overexpression |
T13256 | 23123-23127 | IN | denotes | upon |
T13255 | 23115-23122 | NNS | denotes | stimuli |
T13254 | 23102-23114 | JJ | denotes | inflammatory |
T13253 | 23096-23101 | JJ | denotes | other |
T13252 | 23088-23095 | JJ | denotes | several |
T13251 | 23084-23087 | CC | denotes | and |
T13250 | 23080-23083 | NNP | denotes | TNF |
T13249 | 23077-23079 | IN | denotes | by |
T13248 | 23066-23076 | NN | denotes | activation |
T13247 | 23060-23065 | JJ | denotes | NF-κB |
T13246 | 23052-23059 | VB | denotes | inhibit |
T13245 | 23049-23051 | TO | denotes | to |
T13244 | 23043-23048 | VBN | denotes | shown |
T13243 | 23038-23042 | VBD | denotes | were |
T13242 | 23034-23037 | CC | denotes | and |
T13241 | 23025-23033 | NNS | denotes | proteins |
T13240 | 23013-23024 | VBG | denotes | interacting |
T13239 | 23009-23012 | NNP | denotes | A20 |
T13238 | 22999-23008 | VBN | denotes | expressed |
T13237 | 22986-22998 | RB | denotes | ubiquitously |
T13236 | 22983-22985 | IN | denotes | as |
T13235 | 22972-22982 | VBN | denotes | identified |
T13234 | 22967-22971 | VBD | denotes | were |
T13233 | 22965-22966 | -RRB- | denotes | ) |
T13232 | 22959-22965 | NNP | denotes | TNIP-3 |
T13231 | 22955-22958 | CC | denotes | and |
T13230 | 22953-22954 | , | denotes | , |
T13229 | 22947-22953 | CD | denotes | TNIP-2 |
T13228 | 22945-22946 | , | denotes | , |
T13227 | 22939-22945 | CD | denotes | TNIP-1 |
T13226 | 22936-22938 | IN | denotes | as |
T13225 | 22930-22935 | VBN | denotes | known |
T13224 | 22925-22929 | RB | denotes | also |
T13223 | 22924-22925 | -LRB- | denotes | ( |
T13222 | 22917-22923 | NNP | denotes | ABIN-3 |
T13221 | 22913-22916 | CC | denotes | and |
T13220 | 22906-22912 | NNP | denotes | ABIN-2 |
T13219 | 22904-22905 | , | denotes | , |
T13218 | 22898-22904 | NNP | denotes | ABIN-1 |
T13217 | 22892-22897 | NNP | denotes | NF-κB |
T13216 | 22889-22891 | IN | denotes | of |
T13215 | 22878-22888 | NNS | denotes | inhibitors |
T13214 | 22866-22877 | JJ | denotes | A20-binding |
T13561 | 24962-24963 | , | denotes | , |
T13560 | 24951-24962 | NN | denotes | involvement |
T13559 | 24945-24950 | JJ | denotes | joint |
T13558 | 24942-24944 | IN | denotes | in |
T13557 | 24934-24941 | VBP | denotes | overlap |
T13556 | 24925-24933 | JJ | denotes | clinical |
T13555 | 24920-24924 | DT | denotes | some |
T13553 | 24906-24914 | NNS | denotes | diseases |
T13552 | 24902-24905 | CD | denotes | two |
T13551 | 24898-24901 | DT | denotes | the |
T13550 | 24895-24897 | IN | denotes | as |
T13549 | 24886-24894 | VBN | denotes | expected |
T13548 | 24883-24885 | VB | denotes | be |
T13547 | 24877-24882 | MD | denotes | might |
T13546 | 24872-24876 | NN | denotes | loci |
T13545 | 24857-24871 | NN | denotes | susceptibility |
T13544 | 24854-24856 | NNP | denotes | RA |
T13543 | 24850-24853 | CC | denotes | and |
T13542 | 24836-24849 | NNS | denotes | erythematosus |
T13541 | 24830-24835 | NN | denotes | lupus |
T13540 | 24821-24829 | JJ | denotes | systemic |
T13539 | 24813-24820 | IN | denotes | between |
T13538 | 24805-24812 | VBP | denotes | overlap |
T13537 | 24802-24804 | IN | denotes | of |
T13536 | 24795-24801 | NN | denotes | degree |
T13535 | 24790-24794 | JJ | denotes | high |
T13534 | 24788-24789 | DT | denotes | A |
T13533 | 24786-24787 | . | denotes | . |
T13532 | 24785-24786 | NNP | denotes | ] |
T13531 | 24780-24785 | CD | denotes | 61,62 |
T13530 | 24779-24780 | NNP | denotes | [ |
T13529 | 24772-24778 | NNS | denotes | humans |
T13528 | 24769-24771 | IN | denotes | in |
T13527 | 24755-24768 | VBZ | denotes | erythematosus |
T13526 | 24749-24754 | NN | denotes | lupus |
T13525 | 24740-24748 | JJ | denotes | systemic |
T13524 | 24736-24739 | CC | denotes | and |
T13523 | 24726-24735 | NN | denotes | psoriasis |
T13522 | 24721-24725 | IN | denotes | with |
T13521 | 24710-24720 | VBN | denotes | associated |
T13520 | 24705-24709 | VBN | denotes | been |
T13519 | 24700-24704 | VBP | denotes | have |
T13518 | 24686-24699 | NNS | denotes | polymorphisms |
T13517 | 24679-24685 | JJ | denotes | ABIN-1 |
T13516 | 24677-24678 | , | denotes | , |
T13515 | 24664-24677 | RB | denotes | Interestingly |
T13514 | 24662-24663 | . | denotes | . |
T13513 | 24661-24662 | NNP | denotes | ] |
T13512 | 24659-24661 | CD | denotes | 60 |
T13511 | 24658-24659 | NNP | denotes | [ |
T13510 | 24646-24657 | NNS | denotes | macrophages |
T13509 | 24637-24645 | JJ | denotes | synovial |
T13508 | 24627-24636 | NNS | denotes | arthritis |
T13507 | 24614-24626 | JJ | denotes | inflammatory |
T13506 | 24611-24613 | IN | denotes | in |
T13505 | 24600-24610 | VBN | denotes | suppressed |
T13504 | 24591-24599 | RB | denotes | strongly |
T13503 | 24587-24590 | VBD | denotes | was |
T13502 | 24582-24586 | NNP | denotes | ITAM |
T13501 | 24578-24581 | DT | denotes | the |
T13500 | 24575-24577 | IN | denotes | of |
T13499 | 24568-24574 | NN | denotes | effect |
T13498 | 24557-24567 | JJ | denotes | protective |
T13497 | 24552-24556 | DT | denotes | this |
T13496 | 24550-24551 | , | denotes | , |
T13495 | 24542-24550 | RB | denotes | Moreover |
T13494 | 24540-24541 | . | denotes | . |
T13493 | 24537-24540 | NNP | denotes | A20 |
T13492 | 24533-24536 | CC | denotes | and |
T13491 | 24526-24532 | JJ | denotes | ABIN-3 |
T13490 | 24517-24525 | NNS | denotes | proteins |
T13489 | 24506-24516 | NN | denotes | inhibitory |
T13488 | 24500-24505 | JJ | denotes | NF-κB |
T13487 | 24496-24499 | DT | denotes | the |
T13486 | 24493-24495 | IN | denotes | of |
T13485 | 24482-24492 | NN | denotes | expression |
T13484 | 24478-24481 | DT | denotes | the |
T13483 | 24475-24477 | IN | denotes | on |
T13482 | 24468-24474 | VB | denotes | depend |
T13481 | 24465-24467 | TO | denotes | to |
T13480 | 24459-24464 | VBN | denotes | shown |
T13479 | 24455-24458 | VBD | denotes | was |
T13478 | 24445-24454 | NNS | denotes | receptors |
T13477 | 24437-24444 | VBN | denotes | coupled |
T13476 | 24436-24437 | : | denotes | - |
T13475 | 24435-24436 | -RRB- | denotes | ) |
T13474 | 24431-24435 | NNP | denotes | ITAM |
T13473 | 24430-24431 | -LRB- | denotes | ( |
T13472 | 24424-24429 | NN | denotes | motif |
T13471 | 24413-24423 | NN | denotes | activation |
T13470 | 24398-24412 | JJ | denotes | tyrosine-based |
T13469 | 24383-24397 | JJ | denotes | immunoreceptor |
T13468 | 24380-24382 | IN | denotes | by |
T13467 | 24370-24379 | NNS | denotes | responses |
T13466 | 24366-24369 | NNP | denotes | TLR |
T13465 | 24363-24365 | IN | denotes | of |
T13464 | 24352-24362 | NN | denotes | inhibition |
T13463 | 24350-24351 | , | denotes | , |
T13462 | 24345-24350 | NN | denotes | study |
T13461 | 24338-24344 | JJ | denotes | recent |
T13460 | 24336-24337 | DT | denotes | a |
T13459 | 24333-24335 | IN | denotes | In |
T13458 | 24331-24332 | . | denotes | . |
T13457 | 24330-24331 | NNP | denotes | ] |
T13456 | 24328-24330 | CD | denotes | 59 |
T13455 | 24327-24328 | NNP | denotes | [ |
T13454 | 24324-24326 | NNP | denotes | RA |
T13453 | 24321-24323 | IN | denotes | of |
T13452 | 24308-24320 | NN | denotes | pathogenesis |
T13451 | 24304-24307 | DT | denotes | the |
T13450 | 24300-24303 | CC | denotes | and |
T13449 | 24289-24299 | NN | denotes | signalling |
T13448 | 24283-24288 | JJ | denotes | NF-κB |
T13447 | 24280-24282 | IN | denotes | of |
T13446 | 24269-24279 | NN | denotes | regulation |
T13445 | 24260-24268 | NN | denotes | feedback |
T13444 | 24251-24259 | JJ | denotes | negative |
T13443 | 24247-24250 | DT | denotes | the |
T13442 | 24244-24246 | IN | denotes | in |
T13441 | 24242-24243 | , | denotes | , |
T13440 | 24239-24242 | NNP | denotes | A20 |
T13439 | 24234-24238 | IN | denotes | with |
T13438 | 24225-24233 | RB | denotes | together |
T13437 | 24223-24224 | , | denotes | , |
T13436 | 24217-24223 | NNP | denotes | ABIN-1 |
T13435 | 24213-24216 | IN | denotes | for |
T13434 | 24208-24212 | NN | denotes | role |
T13433 | 24198-24207 | JJ | denotes | potential |
T13432 | 24196-24197 | DT | denotes | a |
T13431 | 24185-24195 | VBG | denotes | indicating |
T13430 | 24183-24184 | , | denotes | , |
T13429 | 24175-24183 | NNS | denotes | biopsies |
T13428 | 24168-24174 | NN | denotes | tissue |
T13427 | 24165-24167 | NNP | denotes | RA |
T13426 | 24162-24164 | IN | denotes | in |
T13425 | 24153-24161 | VBN | denotes | detected |
T13424 | 24148-24152 | VBD | denotes | were |
T13423 | 24143-24147 | NNP | denotes | mRNA |
T13422 | 24136-24142 | NNP | denotes | ABIN-1 |
T13421 | 24133-24135 | IN | denotes | of |
T13420 | 24126-24132 | NNS | denotes | levels |
T13419 | 24121-24125 | JJ | denotes | high |
T13418 | 24117-24120 | CC | denotes | and |
T13417 | 24115-24116 | , | denotes | , |
T13416 | 24103-24115 | NNS | denotes | synoviocytes |
T13415 | 24097-24102 | JJ | denotes | human |
T13414 | 24094-24096 | IN | denotes | in |
T13413 | 24088-24093 | NNS | denotes | genes |
T13412 | 24076-24087 | JJ | denotes | TNF-induced |
T13411 | 24070-24075 | IN | denotes | among |
T13410 | 24059-24069 | VBN | denotes | identified |
T13409 | 24055-24058 | VBD | denotes | was |
T13408 | 24048-24054 | NN | denotes | ABIN-1 |
T13407 | 24046-24047 | , | denotes | , |
T13406 | 24038-24046 | NN | denotes | analysis |
T13405 | 24027-24037 | NN | denotes | microarray |
T13404 | 24011-24026 | NN | denotes | oligonucleotide |
T13403 | 24005-24010 | VBG | denotes | Using |
T13402 | 24003-24004 | . | denotes | . |
T13401 | 24002-24003 | NNP | denotes | ] |
T13400 | 24000-24002 | CD | denotes | 56 |
T13399 | 23999-24000 | NNP | denotes | [ |
T13398 | 23989-23998 | NN | denotes | apoptosis |
T13397 | 23983-23988 | NN | denotes | liver |
T13396 | 23976-23982 | JJ | denotes | foetal |
T13395 | 23962-23975 | JJ | denotes | TNF-dependent |
T13394 | 23959-23961 | TO | denotes | to |
T13393 | 23955-23958 | JJ | denotes | due |
T13392 | 23941-23954 | RB | denotes | embryonically |
T13391 | 23937-23940 | VBP | denotes | die |
T11686 | 22863-22864 | . | denotes | . |
T11685 | 22858-22863 | NNS | denotes | tools |
T11684 | 22849-22857 | JJ | denotes | valuable |
T11683 | 22844-22848 | RB | denotes | very |
T11682 | 22841-22843 | VB | denotes | be |
T11681 | 22836-22840 | MD | denotes | will |
T11680 | 22834-22835 | , | denotes | , |
T11679 | 22832-22834 | NNP | denotes | RA |
T11678 | 22828-22831 | IN | denotes | for |
T11677 | 22821-22827 | NNS | denotes | models |
T11676 | 22815-22820 | NN | denotes | mouse |
T11675 | 22810-22814 | IN | denotes | with |
T11674 | 22801-22809 | VBN | denotes | combined |
T11673 | 22799-22800 | , | denotes | , |
T11672 | 22795-22799 | NNS | denotes | SNPs |
T11671 | 22791-22794 | NNP | denotes | A20 |
T11670 | 22777-22790 | JJ | denotes | corresponding |
T11669 | 22773-22776 | DT | denotes | the |
T11668 | 22769-22772 | IN | denotes | for |
T11667 | 22764-22768 | NNS | denotes | mice |
T11666 | 22756-22763 | FW | denotes | knockin |
T11665 | 22754-22755 | , | denotes | , |
T11664 | 22747-22754 | NN | denotes | context |
T11663 | 22742-22746 | DT | denotes | this |
T11662 | 22739-22741 | IN | denotes | In |
T11661 | 22737-22738 | . | denotes | . |
T11660 | 22729-22737 | NNS | denotes | variants |
T11659 | 22723-22728 | DT | denotes | these |
T11658 | 22720-22722 | IN | denotes | of |
T11657 | 22707-22719 | NNS | denotes | consequences |
T11656 | 22696-22706 | JJ | denotes | functional |
T11655 | 22692-22695 | DT | denotes | the |
T11654 | 22682-22691 | VB | denotes | elucidate |
T11653 | 22679-22681 | TO | denotes | to |
T11652 | 22675-22678 | CC | denotes | and |
T11651 | 22666-22674 | NNS | denotes | variants |
T11650 | 22659-22665 | JJ | denotes | causal |
T11649 | 22652-22658 | JJ | denotes | actual |
T11648 | 22648-22651 | DT | denotes | the |
T11647 | 22639-22647 | VB | denotes | identify |
T11646 | 22636-22638 | TO | denotes | to |
T11645 | 22627-22635 | NN | denotes | interest |
T11644 | 22624-22626 | IN | denotes | of |
T11643 | 22621-22623 | VB | denotes | be |
T11642 | 22616-22620 | MD | denotes | will |
T11641 | 22613-22615 | PRP | denotes | It |
T11640 | 22611-22612 | . | denotes | . |
T11639 | 22610-22611 | NNP | denotes | ] |
T11638 | 22608-22610 | CD | denotes | 53 |
T11637 | 22607-22608 | NNP | denotes | [ |
T11636 | 22594-22606 | VBD | denotes | investigated |
T11635 | 22589-22593 | NNS | denotes | SNPs |
T11634 | 22585-22588 | DT | denotes | the |
T11633 | 22582-22584 | IN | denotes | of |
T11632 | 22577-22581 | DT | denotes | some |
T11631 | 22573-22576 | IN | denotes | for |
T11630 | 22559-22572 | NN | denotes | transcription |
T11629 | 22555-22558 | NNP | denotes | A20 |
T11628 | 22545-22554 | JJ | denotes | repressed |
T11627 | 22540-22544 | VB | denotes | show |
T11626 | 22534-22539 | MD | denotes | could |
T11625 | 22530-22533 | CC | denotes | and |
T11624 | 22528-22529 | , | denotes | , |
T11623 | 22520-22528 | NN | denotes | activity |
T11622 | 22511-22519 | NN | denotes | promoter |
T11621 | 22507-22510 | NNP | denotes | A20 |
T11620 | 22504-22506 | IN | denotes | on |
T11619 | 22495-22503 | NNS | denotes | variants |
T11618 | 22491-22494 | NNP | denotes | SNP |
T11617 | 22477-22490 | JJ | denotes | RA-associated |
T11616 | 22474-22476 | IN | denotes | of |
T11615 | 22466-22473 | NN | denotes | ability |
T11614 | 22455-22465 | JJ | denotes | regulatory |
T11613 | 22451-22454 | DT | denotes | the |
T11612 | 22445-22450 | NN | denotes | vitro |
T11611 | 22442-22444 | IN | denotes | in |
T11610 | 22432-22441 | VBN | denotes | evaluated |
T11609 | 22419-22431 | RB | denotes | functionally |
T11608 | 22408-22418 | NNS | denotes | colleagues |
T11607 | 22404-22407 | CC | denotes | and |
T11606 | 22398-22403 | NNP | denotes | Elsby |
T11605 | 22396-22397 | , | denotes | , |
T11604 | 22388-22396 | RB | denotes | Recently |
T11603 | 22386-22387 | . | denotes | . |
T11602 | 22379-22386 | JJ | denotes | unclear |
T11601 | 22372-22378 | VBP | denotes | remain |
T11600 | 22370-22371 | , | denotes | , |
T11599 | 22363-22370 | RB | denotes | however |
T11598 | 22361-22362 | , | denotes | , |
T11597 | 22359-22361 | NNP | denotes | RA |
T11596 | 22353-22358 | VBP | denotes | cause |
T11595 | 22348-22352 | PRP | denotes | they |
T11594 | 22344-22347 | WRB | denotes | how |
T11593 | 22340-22343 | CC | denotes | and |
T11592 | 22331-22339 | NN | denotes | activity |
T11591 | 22327-22330 | JJ | denotes | A20 |
T11590 | 22320-22326 | JJ | denotes | normal |
T11589 | 22313-22319 | VBP | denotes | affect |
T11588 | 22304-22312 | NNS | denotes | variants |
T11587 | 22298-22303 | DT | denotes | these |
T11586 | 22294-22297 | WRB | denotes | How |
T11585 | 22292-22293 | . | denotes | . |
T11584 | 22290-22292 | NNP | denotes | RA |
T11583 | 22286-22289 | IN | denotes | for |
T11582 | 22280-22285 | NN | denotes | locus |
T11581 | 22265-22279 | NN | denotes | susceptibility |
T11580 | 22255-22264 | NN | denotes | candidate |
T11579 | 22253-22254 | DT | denotes | a |
T11578 | 22250-22252 | IN | denotes | as |
T11577 | 22246-22249 | NNP | denotes | A20 |
T11576 | 22239-22245 | VBP | denotes | reveal |
T11575 | 22230-22238 | NNS | denotes | findings |
T11574 | 22224-22229 | DT | denotes | these |
T11573 | 22222-22223 | , | denotes | , |
T11572 | 22220-22222 | NNP | denotes | RA |
T11571 | 22217-22219 | IN | denotes | in |
T11570 | 22208-22216 | NN | denotes | cytokine |
T11569 | 22195-22207 | JJ | denotes | inflammatory |
T11568 | 22187-22194 | JJ | denotes | primary |
T11567 | 22183-22186 | DT | denotes | the |
T11566 | 22180-22182 | VBZ | denotes | is |
T11565 | 22176-22179 | NNP | denotes | TNF |
T11564 | 22172-22175 | CC | denotes | and |
T11563 | 22170-22171 | , | denotes | , |
T11562 | 22163-22170 | NNS | denotes | signals |
T11561 | 22151-22162 | JJ | denotes | TNF-induced |
T11560 | 22148-22150 | IN | denotes | of |
T11559 | 22136-22147 | NN | denotes | termination |
T11558 | 22132-22135 | IN | denotes | for |
T11557 | 22123-22131 | VBN | denotes | required |
T11556 | 22120-22122 | VBZ | denotes | is |
T11555 | 22116-22119 | NNP | denotes | A20 |
T11554 | 22113-22115 | IN | denotes | As |
T11417 | 21349-21357 | NN | denotes | activity |
T11416 | 21345-21348 | CC | denotes | and |
T11415 | 21338-21344 | NN | denotes | number |
T11414 | 21327-21337 | JJ | denotes | osteoclast |
T11413 | 21323-21326 | DT | denotes | the |
T11412 | 21312-21322 | VBG | denotes | decreasing |
T11411 | 21304-21311 | IN | denotes | through |
T11410 | 21292-21303 | NN | denotes | destruction |
T11409 | 21286-21291 | JJ | denotes | joint |
T11408 | 21277-21285 | VB | denotes | minimise |
T11407 | 21267-21276 | RB | denotes | therefore |
T11406 | 21261-21266 | MD | denotes | might |
T11405 | 21257-21260 | RB | denotes | A20 |
T11404 | 21255-21256 | . | denotes | . |
T11403 | 21249-21255 | NN | denotes | tissue |
T11402 | 21243-21248 | JJ | denotes | joint |
T11401 | 21240-21242 | IN | denotes | in |
T11400 | 21228-21239 | NNS | denotes | osteoclasts |
T11399 | 21218-21227 | VBN | denotes | activated |
T11398 | 21215-21217 | IN | denotes | of |
T11397 | 21208-21214 | NN | denotes | number |
T11396 | 21204-21207 | DT | denotes | the |
T11395 | 21201-21203 | IN | denotes | in |
T11394 | 21192-21200 | NN | denotes | decrease |
T11393 | 21190-21191 | DT | denotes | a |
T11392 | 21187-21189 | TO | denotes | to |
T11391 | 21181-21186 | VBZ | denotes | leads |
T11390 | 21166-21180 | NN | denotes | overexpression |
T11389 | 21162-21165 | CD | denotes | A20 |
T11388 | 21157-21161 | IN | denotes | that |
T11387 | 21144-21156 | VBD | denotes | demonstrated |
T11386 | 21139-21143 | RB | denotes | also |
T11385 | 21133-21138 | NN | denotes | study |
T11384 | 21128-21132 | DT | denotes | This |
T11383 | 21126-21127 | . | denotes | . |
T11382 | 21118-21126 | NNS | denotes | findings |
T11381 | 21105-21117 | JJ | denotes | radiological |
T11380 | 21101-21104 | CC | denotes | and |
T11379 | 21099-21100 | , | denotes | , |
T11378 | 21087-21099 | JJ | denotes | pathological |
T11377 | 21085-21086 | , | denotes | , |
T11376 | 21077-21085 | JJ | denotes | clinical |
T11375 | 21073-21076 | DT | denotes | the |
T11374 | 21070-21072 | IN | denotes | in |
T11373 | 21062-21069 | NNS | denotes | effects |
T11372 | 21051-21061 | JJ | denotes | beneficial |
T11371 | 21047-21050 | DT | denotes | the |
T11370 | 21039-21046 | VB | denotes | explain |
T11369 | 21033-21038 | MD | denotes | might |
T11368 | 21028-21032 | NNS | denotes | mice |
T11367 | 21013-21027 | JJ | denotes | A20-transduced |
T11366 | 21010-21012 | IN | denotes | in |
T11365 | 21004-21009 | NNP | denotes | IL-1β |
T11364 | 21000-21003 | CC | denotes | and |
T11363 | 20996-20999 | NNP | denotes | TNF |
T11362 | 20993-20995 | IN | denotes | of |
T11361 | 20986-20992 | NNS | denotes | levels |
T11360 | 20980-20985 | NN | denotes | serum |
T11359 | 20970-20979 | VBN | denotes | decreased |
T11358 | 20966-20969 | DT | denotes | the |
T11357 | 20964-20965 | , | denotes | , |
T11356 | 20962-20964 | NNP | denotes | RA |
T11355 | 20959-20961 | IN | denotes | in |
T11354 | 20954-20958 | NN | denotes | bone |
T11353 | 20950-20953 | CC | denotes | and |
T11352 | 20940-20949 | NN | denotes | cartilage |
T11351 | 20937-20939 | IN | denotes | of |
T11350 | 20929-20936 | NN | denotes | erosion |
T11349 | 20925-20928 | CC | denotes | and |
T11348 | 20923-20924 | , | denotes | , |
T11347 | 20914-20923 | NN | denotes | formation |
T11346 | 20907-20913 | NN | denotes | pannus |
T11345 | 20905-20906 | , | denotes | , |
T11344 | 20896-20905 | NNS | denotes | synovitis |
T11343 | 20888-20895 | VB | denotes | mediate |
T11342 | 20885-20887 | TO | denotes | to |
T11341 | 20879-20884 | VBN | denotes | known |
T11340 | 20875-20878 | VBP | denotes | are |
T11339 | 20869-20874 | NNP | denotes | IL-1β |
T11338 | 20865-20868 | CC | denotes | and |
T11337 | 20861-20864 | NNP | denotes | TNF |
T11336 | 20853-20860 | IN | denotes | Because |
T11335 | 20851-20852 | . | denotes | . |
T11334 | 20850-20851 | NNP | denotes | ] |
T11333 | 20848-20850 | CD | denotes | 51 |
T11332 | 20847-20848 | NNP | denotes | [ |
T11331 | 20836-20846 | NN | denotes | expression |
T11330 | 20831-20835 | NN | denotes | gene |
T11329 | 20818-20830 | JJ | denotes | κB-dependent |
T11328 | 20816-20817 | : | denotes | - |
T11327 | 20814-20816 | SYM | denotes | NF |
T11326 | 20810-20813 | CC | denotes | and |
T11325 | 20799-20809 | NN | denotes | activation |
T11324 | 20793-20798 | JJ | denotes | NF-κB |
T11323 | 20790-20792 | IN | denotes | of |
T11322 | 20778-20789 | NN | denotes | suppression |
T11321 | 20770-20777 | IN | denotes | through |
T11320 | 20765-20769 | NNS | denotes | mice |
T11319 | 20755-20764 | NNS | denotes | arthritis |
T11318 | 20738-20754 | JJ | denotes | collagen-induced |
T11317 | 20735-20737 | IN | denotes | in |
T11316 | 20728-20734 | NN | denotes | effect |
T11315 | 20717-20727 | JJ | denotes | protective |
T11314 | 20715-20716 | DT | denotes | a |
T11313 | 20707-20714 | VBZ | denotes | induces |
T11312 | 20703-20706 | NNP | denotes | A20 |
T11311 | 20698-20702 | IN | denotes | that |
T11310 | 20687-20697 | VBG | denotes | suggesting |
T11309 | 20685-20686 | , | denotes | , |
T11308 | 20680-20685 | NNP | denotes | IL-17 |
T11307 | 20676-20679 | CC | denotes | and |
T11306 | 20674-20675 | , | denotes | , |
T11305 | 20673-20674 | CD | denotes | 1 |
T11304 | 20665-20672 | NN | denotes | protein |
T11303 | 20648-20664 | JJ | denotes | chemo-attractant |
T11302 | 20639-20647 | JJ | denotes | monocyte |
T11301 | 20637-20638 | , | denotes | , |
T11300 | 20632-20637 | NNP | denotes | RANKL |
T11299 | 20624-20631 | JJ | denotes | soluble |
T11298 | 20622-20623 | , | denotes | , |
T11297 | 20618-20622 | NNP | denotes | IL-6 |
T11296 | 20616-20617 | , | denotes | , |
T11295 | 20611-20616 | NNP | denotes | IL-1β |
T11294 | 20609-20610 | , | denotes | , |
T11293 | 20606-20609 | NNP | denotes | TNF |
T11292 | 20603-20605 | IN | denotes | of |
T11291 | 20596-20602 | NNS | denotes | levels |
T11290 | 20586-20595 | VBD | denotes | decreased |
T11289 | 20582-20585 | CC | denotes | and |
T11288 | 20573-20581 | NN | denotes | activity |
T11287 | 20567-20572 | JJ | denotes | NF-κB |
T11286 | 20564-20566 | IN | denotes | of |
T11285 | 20553-20563 | NN | denotes | inhibition |
T11284 | 20548-20552 | IN | denotes | with |
T11283 | 20537-20547 | VBN | denotes | associated |
T11282 | 20533-20536 | VBD | denotes | was |
T11281 | 20526-20532 | NN | denotes | tissue |
T11280 | 20517-20525 | JJ | denotes | synovial |
T11279 | 20514-20516 | IN | denotes | in |
T11278 | 20503-20513 | NN | denotes | expression |
T11277 | 20499-20502 | CD | denotes | A20 |
T11276 | 20497-20498 | . | denotes | . |
T11275 | 20490-20497 | NN | denotes | setting |
T11274 | 20478-20489 | JJ | denotes | therapeutic |
T11273 | 20474-20477 | CC | denotes | and |
T11272 | 20461-20473 | NN | denotes | prophylactic |
T11271 | 20459-20460 | DT | denotes | a |
T11270 | 20454-20458 | DT | denotes | both |
T11269 | 20451-20453 | IN | denotes | in |
T11268 | 20449-20450 | , | denotes | , |
T11267 | 20443-20449 | NNS | denotes | joints |
T11266 | 20433-20442 | JJ | denotes | untreated |
T11265 | 20430-20432 | IN | denotes | in |
T11264 | 20425-20429 | RB | denotes | even |
T11263 | 20423-20424 | , | denotes | , |
T11262 | 20414-20423 | NNS | denotes | arthritis |
T11261 | 20397-20413 | JJ | denotes | collagen-induced |
T11260 | 20394-20396 | IN | denotes | of |
T11259 | 20388-20393 | NN | denotes | model |
T11258 | 20382-20387 | NN | denotes | mouse |
T11257 | 20380-20381 | DT | denotes | a |
T11256 | 20377-20379 | IN | denotes | in |
T11255 | 20365-20376 | NN | denotes | destruction |
T11254 | 20359-20364 | JJ | denotes | joint |
T11253 | 20355-20358 | CC | denotes | and |
T11252 | 20342-20354 | NN | denotes | inflammation |
T11251 | 20333-20341 | JJ | denotes | synovial |
T11250 | 20330-20332 | IN | denotes | of |
T11249 | 20321-20329 | NN | denotes | severity |
T11248 | 20317-20320 | DT | denotes | the |
T11247 | 20310-20316 | VB | denotes | reduce |
T11246 | 20307-20309 | TO | denotes | to |
T11245 | 20301-20306 | VBN | denotes | shown |
T11244 | 20297-20300 | VBD | denotes | was |
T11243 | 20286-20296 | NN | denotes | adenovirus |
T11242 | 20271-20285 | JJ | denotes | A20-expressing |
T11241 | 20268-20270 | DT | denotes | an |
T11240 | 20265-20267 | IN | denotes | of |
T11239 | 20255-20264 | NN | denotes | injection |
T11238 | 20239-20254 | JJ | denotes | intra-articular |
T11237 | 20237-20238 | , | denotes | , |
T11236 | 20229-20237 | RB | denotes | Recently |
T11235 | 20227-20228 | . | denotes | . |
T11234 | 20217-20227 | NN | denotes | signalling |
T11233 | 20211-20216 | JJ | denotes | NF-κB |
T11232 | 20208-20210 | IN | denotes | of |
T11231 | 20197-20207 | NN | denotes | regulation |
T11230 | 20188-20196 | NN | denotes | feedback |
T11229 | 20179-20187 | JJ | denotes | negative |
T11228 | 20175-20178 | DT | denotes | the |
T11227 | 20172-20174 | IN | denotes | in |
T11226 | 20168-20171 | NNP | denotes | A20 |
T11225 | 20156-20167 | VBG | denotes | implicating |
T11224 | 20154-20155 | , | denotes | , |
T11223 | 20153-20154 | NNP | denotes | ] |
T11222 | 20151-20153 | CD | denotes | 50 |
T11221 | 20150-20151 | NNP | denotes | [ |
T11220 | 20144-20149 | NNP | denotes | NF-κB |
T11219 | 20141-20143 | IN | denotes | by |
T11218 | 20131-20140 | VBN | denotes | regulated |
T11217 | 20124-20130 | PRP | denotes | itself |
T11216 | 20121-20123 | VBZ | denotes | is |
T11215 | 20110-20120 | NN | denotes | expression |
T11214 | 20106-20109 | NNP | denotes | A20 |
T11213 | 20104-20105 | , | denotes | , |
T11212 | 20091-20104 | RB | denotes | Interestingly |
T11211 | 20089-20090 | . | denotes | . |
T11210 | 20078-20089 | NNS | denotes | lymphocytes |
T11209 | 20074-20077 | CC | denotes | and |
T11208 | 20061-20073 | NNS | denotes | synoviocytes |
T11207 | 20059-20060 | , | denotes | , |
T11206 | 20048-20059 | NNS | denotes | fibroblasts |
T11205 | 20045-20047 | IN | denotes | as |
T11204 | 20040-20044 | JJ | denotes | such |
T11203 | 20038-20039 | , | denotes | , |
T11202 | 20036-20038 | NNP | denotes | RA |
T11193 | 19978-19983 | NNS | denotes | types |
T11192 | 19973-19977 | NN | denotes | cell |
T11191 | 19965-19972 | JJ | denotes | several |
T11190 | 19962-19964 | IN | denotes | in |
T11189 | 19953-19961 | VBN | denotes | observed |
T11188 | 19948-19952 | VBN | denotes | been |
T11187 | 19944-19947 | VBZ | denotes | has |
T11186 | 19933-19943 | NN | denotes | expression |
T11185 | 19929-19932 | CD | denotes | A20 |
T11184 | 19927-19928 | . | denotes | . |
T11183 | 19926-19927 | NNP | denotes | ] |
T11182 | 19921-19926 | CD | denotes | 48,49 |
T11181 | 19920-19921 | NNP | denotes | [ |
T11180 | 19911-19919 | NN | denotes | survival |
T11179 | 19904-19910 | NN | denotes | B-cell |
T11178 | 19891-19903 | JJ | denotes | unrestricted |
T11177 | 19888-19890 | TO | denotes | to |
T11176 | 19880-19887 | VBG | denotes | leading |
T11175 | 19874-19879 | NNS | denotes | cells |
T11174 | 19872-19873 | NNP | denotes | B |
T11173 | 19869-19871 | IN | denotes | in |
T11172 | 19859-19868 | NNS | denotes | responses |
T11171 | 19853-19858 | NN | denotes | NF-κB |
T11170 | 19841-19852 | JJ | denotes | hyperactive |
T11169 | 19838-19840 | TO | denotes | to |
T11168 | 19834-19837 | JJ | denotes | due |
T11167 | 19821-19833 | NN | denotes | autoimmunity |
T11166 | 19813-19820 | VBP | denotes | develop |
T11165 | 19807-19812 | NNS | denotes | cells |
T11164 | 19805-19806 | NNP | denotes | B |
T11163 | 19802-19804 | IN | denotes | in |
T11162 | 19798-19801 | NNP | denotes | A20 |
T11161 | 19790-19797 | VBG | denotes | lacking |
T11160 | 19785-19789 | NNS | denotes | mice |
T11159 | 19780-19784 | IN | denotes | that |
T11158 | 19773-19779 | VBD | denotes | showed |
T11157 | 19765-19772 | NNS | denotes | studies |
T11156 | 19753-19764 | JJ | denotes | independent |
T11155 | 19749-19752 | CD | denotes | Two |
T11154 | 19747-19748 | . | denotes | . |
T11153 | 19746-19747 | NNP | denotes | ] |
T11152 | 19744-19746 | CD | denotes | 47 |
T11151 | 19743-19744 | NNP | denotes | [ |
T11150 | 19732-19742 | NN | denotes | epithelium |
T11149 | 19721-19731 | JJ | denotes | intestinal |
T11148 | 19717-19720 | DT | denotes | the |
T11147 | 19714-19716 | IN | denotes | in |
T11146 | 19706-19713 | NN | denotes | protein |
T11145 | 19692-19705 | JJ | denotes | antiapoptotic |
T11144 | 19686-19691 | JJ | denotes | major |
T11143 | 19684-19685 | DT | denotes | a |
T11142 | 19681-19683 | IN | denotes | as |
T11141 | 19677-19680 | NNP | denotes | A20 |
T11140 | 19666-19676 | VBG | denotes | confirming |
T11139 | 19664-19665 | , | denotes | , |
T11138 | 19655-19664 | NN | denotes | apoptosis |
T11137 | 19643-19654 | JJ | denotes | TNF-induced |
T11136 | 19640-19642 | TO | denotes | to |
T11135 | 19634-19639 | NNS | denotes | cells |
T11134 | 19623-19633 | JJ | denotes | epithelial |
T11133 | 19612-19622 | JJ | denotes | intestinal |
T11132 | 19606-19611 | PRP$ | denotes | their |
T11131 | 19603-19605 | IN | denotes | of |
T11130 | 19586-19602 | NN | denotes | hypersensitivity |
T11129 | 19582-19585 | DT | denotes | the |
T11128 | 19579-19581 | TO | denotes | to |
T11127 | 19575-19578 | JJ | denotes | due |
T11126 | 19567-19574 | NNS | denotes | colitis |
T11125 | 19554-19566 | JJ | denotes | experimental |
T11124 | 19551-19553 | TO | denotes | to |
T11123 | 19536-19550 | NN | denotes | susceptibility |
T11122 | 19526-19535 | VBN | denotes | increased |
T11121 | 19518-19525 | VBP | denotes | exhibit |
T11120 | 19512-19517 | NNS | denotes | cells |
T11119 | 19501-19511 | JJ | denotes | epithelial |
T11118 | 19490-19500 | JJ | denotes | intestinal |
T11117 | 19487-19489 | IN | denotes | in |
T11116 | 19483-19486 | NNP | denotes | A20 |
T11115 | 19475-19482 | VBG | denotes | lacking |
T11114 | 19462-19474 | RB | denotes | specifically |
T11113 | 19457-19461 | NNS | denotes | mice |
T11112 | 19452-19456 | IN | denotes | that |
T11111 | 19445-19451 | VBD | denotes | showed |
T11110 | 19436-19444 | RB | denotes | recently |
T11109 | 19433-19435 | PRP | denotes | We |
T11108 | 19431-19432 | . | denotes | . |
T11107 | 19424-19431 | NN | denotes | protein |
T11106 | 19410-19423 | JJ | denotes | antiapoptotic |
T11105 | 19407-19409 | DT | denotes | an |
T11104 | 19404-19406 | IN | denotes | as |
T11103 | 19399-19403 | NN | denotes | role |
T11102 | 19395-19398 | PRP$ | denotes | its |
T11101 | 19384-19394 | VBG | denotes | confirming |
T11100 | 19382-19383 | , | denotes | , |
T11099 | 19373-19382 | NN | denotes | apoptosis |
T11098 | 19360-19372 | JJ | denotes | TNF-mediated |
T11097 | 19357-19359 | TO | denotes | to |
T11096 | 19345-19356 | JJ | denotes | susceptible |
T11095 | 19340-19344 | RBR | denotes | more |
T11094 | 19335-19339 | RB | denotes | also |
T11553 | 22111-22112 | . | denotes | . |
T11552 | 22105-22111 | NN | denotes | region |
T11551 | 22100-22104 | DT | denotes | this |
T11550 | 22097-22099 | IN | denotes | in |
T11549 | 22088-22096 | NNS | denotes | elements |
T11548 | 22084-22087 | NN | denotes | DNA |
T11547 | 22073-22083 | JJ | denotes | regulatory |
T11546 | 22063-22072 | JJ | denotes | potential |
T11545 | 22060-22062 | IN | denotes | of |
T11544 | 22051-22059 | NN | denotes | presence |
T11543 | 22047-22050 | DT | denotes | the |
T11542 | 22044-22046 | IN | denotes | by |
T11541 | 22035-22043 | RB | denotes | probably |
T11540 | 22033-22034 | , | denotes | , |
T11539 | 22032-22033 | -RRB- | denotes | ) |
T11538 | 22029-22032 | NNP | denotes | A20 |
T11537 | 22026-22028 | IN | denotes | of |
T11536 | 22015-22025 | JJ | denotes | downstream |
T11535 | 22012-22014 | NN | denotes | kb |
T11534 | 22008-22011 | CD | denotes | 150 |
T11533 | 22007-22008 | FW | denotes | ~ |
T11532 | 22006-22007 | -LRB- | denotes | ( |
T11531 | 22001-22005 | NN | denotes | gene |
T11530 | 21993-22000 | JJS | denotes | nearest |
T11529 | 21989-21992 | PRP$ | denotes | its |
T11528 | 21986-21988 | IN | denotes | as |
T11527 | 21982-21985 | NNP | denotes | A20 |
T11526 | 21972-21981 | VB | denotes | influence |
T11525 | 21969-21971 | TO | denotes | to |
T11524 | 21961-21968 | VBN | denotes | thought |
T11523 | 21957-21960 | VBP | denotes | are |
T11522 | 21952-21956 | PRP | denotes | they |
T11521 | 21950-21951 | , | denotes | , |
T11520 | 21946-21950 | NN | denotes | gene |
T11519 | 21944-21945 | DT | denotes | a |
T11518 | 21941-21943 | IN | denotes | in |
T11517 | 21933-21940 | VBN | denotes | located |
T11516 | 21929-21932 | RB | denotes | not |
T11515 | 21925-21928 | VBP | denotes | are |
T11514 | 21916-21924 | NNS | denotes | variants |
T11513 | 21905-21915 | VBN | denotes | identified |
T11512 | 21901-21904 | DT | denotes | the |
T11511 | 21892-21900 | IN | denotes | Although |
T11510 | 21890-21891 | . | denotes | . |
T11509 | 21889-21890 | NNP | denotes | ] |
T11508 | 21887-21889 | CD | denotes | 52 |
T11507 | 21886-21887 | NNP | denotes | [ |
T11506 | 21883-21885 | NNP | denotes | RA |
T11505 | 21880-21882 | TO | denotes | to |
T11504 | 21865-21879 | NN | denotes | susceptibility |
T11503 | 21861-21864 | CC | denotes | and |
T11502 | 21850-21860 | NN | denotes | chromosome |
T11501 | 21845-21849 | JJ | denotes | 6q23 |
T11500 | 21841-21844 | DT | denotes | the |
T11499 | 21838-21840 | IN | denotes | in |
T11498 | 21832-21837 | NN | denotes | locus |
T11497 | 21828-21831 | NNP | denotes | A20 |
T11496 | 21824-21827 | DT | denotes | the |
T11495 | 21821-21823 | IN | denotes | in |
T11494 | 21811-21820 | NNS | denotes | mutations |
T11493 | 21803-21810 | IN | denotes | between |
T11492 | 21791-21802 | NN | denotes | association |
T11491 | 21785-21790 | JJ | denotes | clear |
T11490 | 21783-21784 | DT | denotes | a |
T11489 | 21774-21782 | VBD | denotes | revealed |
T11488 | 21769-21773 | RB | denotes | also |
T11487 | 21761-21768 | NNS | denotes | studies |
T11486 | 21749-21760 | NN | denotes | association |
T11485 | 21737-21748 | JJ | denotes | genome-wide |
T11484 | 21729-21736 | JJ | denotes | Several |
T11483 | 21727-21728 | . | denotes | . |
T11482 | 21726-21727 | -RRB- | denotes | ) |
T11481 | 21725-21726 | NNP | denotes | ] |
T11480 | 21723-21725 | CD | denotes | 52 |
T11479 | 21722-21723 | NNP | denotes | [ |
T11478 | 21719-21721 | IN | denotes | in |
T11477 | 21710-21718 | VBN | denotes | reviewed |
T11476 | 21709-21710 | -LRB- | denotes | ( |
T11475 | 21697-21708 | NNS | denotes | pathologies |
T11474 | 21686-21696 | JJ | denotes | autoimmune |
T11473 | 21683-21685 | IN | denotes | of |
T11472 | 21671-21682 | NN | denotes | development |
T11471 | 21668-21670 | TO | denotes | to |
T11470 | 21653-21667 | NN | denotes | susceptibility |
T11469 | 21643-21652 | VBN | denotes | increased |
T11468 | 21638-21642 | IN | denotes | with |
T11467 | 21627-21637 | VBN | denotes | associated |
T11466 | 21622-21626 | VBN | denotes | been |
T11465 | 21617-21621 | VBP | denotes | have |
T11464 | 21611-21616 | NN | denotes | locus |
T11463 | 21607-21610 | NNP | denotes | A20 |
T11462 | 21601-21606 | JJ | denotes | human |
T11461 | 21597-21600 | DT | denotes | the |
T11460 | 21594-21596 | IN | denotes | in |
T11459 | 21589-21593 | NNS | denotes | SNPs |
T11458 | 21581-21588 | JJ | denotes | several |
T11457 | 21579-21580 | , | denotes | , |
T11456 | 21568-21579 | RB | denotes | Importantly |
T11455 | 21566-21567 | . | denotes | . |
T11454 | 21561-21566 | NNS | denotes | cells |
T11453 | 21559-21560 | NN | denotes | T |
T11452 | 21556-21558 | CC | denotes | or |
T11451 | 21550-21555 | NNS | denotes | cells |
T11450 | 21548-21549 | NNP | denotes | B |
T11449 | 21546-21547 | , | denotes | , |
T11448 | 21541-21546 | NNS | denotes | cells |
T11447 | 21531-21540 | JJ | denotes | dendritic |
T11446 | 21529-21530 | , | denotes | , |
T11445 | 21518-21529 | NNS | denotes | macrophages |
T11444 | 21516-21517 | , | denotes | , |
T11443 | 21505-21516 | NNS | denotes | fibroblasts |
T11442 | 21496-21504 | JJ | denotes | synovial |
T11441 | 21493-21495 | IN | denotes | as |
T11440 | 21488-21492 | JJ | denotes | such |
T11439 | 21482-21487 | NNS | denotes | types |
T11438 | 21477-21481 | NN | denotes | cell |
T11437 | 21468-21476 | JJ | denotes | specific |
T11436 | 21465-21467 | IN | denotes | in |
T11435 | 21461-21464 | CD | denotes | A20 |
T11434 | 21456-21460 | VBP | denotes | lack |
T11433 | 21451-21455 | WDT | denotes | that |
T11432 | 21446-21450 | NNS | denotes | mice |
T11431 | 21437-21445 | NN | denotes | knockout |
T11430 | 21425-21436 | JJ | denotes | conditional |
T11429 | 21422-21424 | IN | denotes | of |
T11428 | 21407-21421 | NN | denotes | susceptibility |
T11427 | 21403-21406 | DT | denotes | the |
T11426 | 21396-21402 | JJ | denotes | future |
T11425 | 21393-21395 | IN | denotes | in |
T11424 | 21385-21392 | VB | denotes | analyse |
T11423 | 21382-21384 | TO | denotes | to |
T11422 | 21370-21381 | JJ | denotes | interesting |
T11421 | 21367-21369 | VB | denotes | be |
T11420 | 21362-21366 | MD | denotes | will |
T11419 | 21359-21361 | PRP | denotes | It |
T11418 | 21357-21358 | . | denotes | . |
T11093 | 19331-19334 | VBP | denotes | are |
T11092 | 19325-19330 | NNS | denotes | cells |
T11091 | 19311-19324 | JJ | denotes | A20-deficient |
T11090 | 19309-19310 | . | denotes | . |
T11089 | 19308-19309 | NNP | denotes | ] |
T11088 | 19306-19308 | CD | denotes | 46 |
T11087 | 19305-19306 | NNP | denotes | [ |
T11086 | 19296-19304 | NN | denotes | molecule |
T11085 | 19291-19295 | DT | denotes | this |
T11084 | 19288-19290 | IN | denotes | of |
T11083 | 19279-19287 | NN | denotes | function |
T11082 | 19261-19278 | JJ | denotes | anti-inflammatory |
T11081 | 19254-19260 | JJ | denotes | potent |
T11080 | 19250-19253 | DT | denotes | the |
T11079 | 19237-19249 | VBG | denotes | illustrating |
T11078 | 19235-19236 | , | denotes | , |
T11077 | 19230-19235 | NN | denotes | birth |
T11076 | 19227-19229 | IN | denotes | of |
T11075 | 19221-19226 | NNS | denotes | weeks |
T11074 | 19219-19220 | CD | denotes | 2 |
T11073 | 19212-19218 | IN | denotes | within |
T11072 | 19208-19211 | VB | denotes | die |
T11071 | 19204-19207 | CC | denotes | and |
T11070 | 19195-19203 | NN | denotes | cachexia |
T11069 | 19191-19194 | CC | denotes | and |
T11068 | 19178-19190 | NN | denotes | inflammation |
T11067 | 19167-19177 | JJ | denotes | multiorgan |
T11066 | 19159-19166 | VBP | denotes | develop |
T11065 | 19145-19158 | RB | denotes | spontaneously |
T11064 | 19140-19144 | NNS | denotes | mice |
T11063 | 19126-19139 | JJ | denotes | A20-deficient |
T11062 | 19124-19125 | . | denotes | . |
T11061 | 19117-19124 | JJ | denotes | elusive |
T11060 | 19111-19116 | RB | denotes | still |
T11059 | 19107-19110 | VBP | denotes | are |
T11058 | 19105-19106 | , | denotes | , |
T11057 | 19098-19105 | RB | denotes | however |
T11056 | 19096-19097 | , | denotes | , |
T11055 | 19086-19096 | NN | denotes | signalling |
T11054 | 19076-19085 | JJ | denotes | apoptotic |
T11053 | 19066-19075 | VBZ | denotes | regulates |
T11052 | 19062-19065 | NNP | denotes | A20 |
T11051 | 19056-19061 | WDT | denotes | which |
T11050 | 19053-19055 | IN | denotes | by |
T11049 | 19042-19052 | NNS | denotes | mechanisms |
T11048 | 19038-19041 | DT | denotes | The |
T11047 | 19036-19037 | . | denotes | . |
T11046 | 19031-19036 | NNS | denotes | types |
T11045 | 19026-19030 | NN | denotes | cell |
T11044 | 19021-19025 | DT | denotes | some |
T11043 | 19018-19020 | IN | denotes | in |
T11042 | 19012-19017 | JJS | denotes | least |
T11041 | 19009-19011 | IN | denotes | at |
T11040 | 19007-19008 | , | denotes | , |
T11039 | 18998-19007 | NN | denotes | apoptosis |
T11038 | 18995-18997 | IN | denotes | of |
T11037 | 18985-18994 | NN | denotes | inhibitor |
T11036 | 18978-18984 | JJ | denotes | strong |
T11035 | 18976-18977 | DT | denotes | a |
T11034 | 18971-18975 | RB | denotes | also |
T11033 | 18968-18970 | VBZ | denotes | is |
T11032 | 18964-18967 | NNP | denotes | A20 |
T11031 | 18962-18963 | , | denotes | , |
T11030 | 18952-18962 | NN | denotes | activation |
T11029 | 18946-18951 | JJ | denotes | NF-κB |
T11028 | 18934-18945 | VBG | denotes | suppressing |
T11027 | 18931-18933 | IN | denotes | in |
T11026 | 18926-18930 | NN | denotes | role |
T11025 | 18922-18925 | PRP$ | denotes | its |
T11024 | 18919-18921 | TO | denotes | to |
T11023 | 18914-18918 | JJ | denotes | Next |
T11022 | 18912-18913 | . | denotes | . |
T11021 | 18911-18912 | NNP | denotes | ] |
T11020 | 18906-18911 | CD | denotes | 43-46 |
T11019 | 18905-18906 | NNP | denotes | [ |
T11018 | 18903-18904 | CD | denotes | 1 |
T11017 | 18895-18902 | NN | denotes | protein |
T11016 | 18882-18894 | JJ | denotes | Tax1-binding |
T11015 | 18878-18881 | CC | denotes | and |
T11014 | 18876-18877 | CD | denotes | 1 |
T11013 | 18874-18875 | -RRB- | denotes | ) |
T11012 | 18870-18874 | NNP | denotes | ABIN |
T11011 | 18869-18870 | -LRB- | denotes | ( |
T11010 | 18863-18868 | NNP | denotes | NF-κB |
T11009 | 18860-18862 | IN | denotes | of |
T11008 | 18850-18859 | NN | denotes | inhibitor |
T11007 | 18838-18849 | JJ | denotes | A20-binding |
T11006 | 18828-18837 | VBG | denotes | including |
T11005 | 18826-18827 | , | denotes | , |
T11004 | 18818-18826 | NNS | denotes | proteins |
T11003 | 18810-18817 | NN | denotes | adaptor |
T11002 | 18792-18809 | JJ | denotes | ubiquitin-binding |
T11001 | 18783-18791 | JJ | denotes | specific |
T11000 | 18774-18782 | VBZ | denotes | requires |
T10999 | 18766-18773 | NNS | denotes | targets |
T10998 | 18762-18765 | PRP$ | denotes | its |
T10997 | 18757-18761 | IN | denotes | with |
T10996 | 18753-18756 | CD | denotes | A20 |
T10995 | 18750-18752 | IN | denotes | of |
T10994 | 18738-18749 | NN | denotes | association |
T10993 | 18734-18737 | DT | denotes | The |
T10992 | 18732-18733 | . | denotes | . |
T10991 | 18731-18732 | NNP | denotes | ] |
T10990 | 18729-18731 | CD | denotes | 42 |
T10989 | 18728-18729 | NNP | denotes | [ |
T10988 | 18717-18727 | JJ | denotes | signalling |
T10987 | 18711-18716 | JJ | denotes | NF-κB |
T10986 | 18698-18710 | VB | denotes | downregulate |
T10985 | 18695-18697 | TO | denotes | to |
T10984 | 18691-18694 | CD | denotes | A20 |
T10983 | 18688-18690 | IN | denotes | by |
T10982 | 18683-18687 | VBN | denotes | used |
T10981 | 18673-18682 | NN | denotes | mechanism |
T10980 | 18663-18672 | JJ | denotes | important |
T10979 | 18655-18662 | DT | denotes | another |
T10978 | 18652-18654 | IN | denotes | as |
T10864 | 17963-17968 | VBN | denotes | known |
T10863 | 17958-17962 | RB | denotes | also |
T10862 | 17957-17958 | -LRB- | denotes | ( |
T10861 | 17953-17956 | NNP | denotes | A20 |
T10860 | 17945-17952 | NN | denotes | protein |
T10859 | 17941-17944 | CD | denotes | A20 |
T11201 | 20033-20035 | IN | denotes | of |
T11200 | 20017-20032 | NN | denotes | pathophysiology |
T11199 | 20013-20016 | DT | denotes | the |
T11198 | 20010-20012 | IN | denotes | in |
T11197 | 20004-20009 | NNS | denotes | roles |
T11196 | 19994-20003 | JJ | denotes | important |
T11195 | 19989-19993 | VBP | denotes | play |
T11194 | 19984-19988 | WDT | denotes | that |
T10977 | 18642-18651 | VBN | denotes | described |
T10976 | 18637-18641 | VBD | denotes | were |
T10975 | 18635-18636 | -RRB- | denotes | ) |
T10974 | 18628-18635 | NNP | denotes | cIAP1/2 |
T10973 | 18624-18627 | CC | denotes | and |
T10972 | 18618-18623 | CD | denotes | TRAF2 |
T10971 | 18616-18617 | , | denotes | , |
T10970 | 18611-18616 | CD | denotes | TRAF6 |
T10969 | 18610-18611 | -LRB- | denotes | ( |
T10968 | 18602-18609 | NNS | denotes | ligases |
T10967 | 18592-18601 | NN | denotes | ubiquitin |
T10966 | 18589-18591 | CD | denotes | E3 |
T10965 | 18585-18588 | CC | denotes | and |
T10964 | 18583-18584 | -RRB- | denotes | ) |
T10963 | 18577-18583 | JJ | denotes | Ubc5hc |
T10962 | 18573-18576 | CC | denotes | and |
T10961 | 18567-18572 | JJ | denotes | Ubc13 |
T10960 | 18566-18567 | -LRB- | denotes | ( |
T10959 | 18558-18565 | NNS | denotes | enzymes |
T10958 | 18546-18557 | VBG | denotes | conjugating |
T10957 | 18536-18545 | NN | denotes | ubiquitin |
T10956 | 18533-18535 | CD | denotes | E2 |
T10955 | 18525-18532 | IN | denotes | between |
T10954 | 18512-18524 | NNS | denotes | interactions |
T10953 | 18509-18511 | IN | denotes | of |
T10952 | 18498-18508 | NN | denotes | disruption |
T10951 | 18494-18497 | DT | denotes | the |
T10950 | 18492-18493 | , | denotes | , |
T10949 | 18484-18492 | RB | denotes | Recently |
T10948 | 18482-18483 | . | denotes | . |
T10947 | 18481-18482 | -RRB- | denotes | ) |
T10946 | 18480-18481 | CD | denotes | 1 |
T10945 | 18473-18479 | NNP | denotes | Figure |
T10944 | 18472-18473 | -LRB- | denotes | ( |
T10943 | 18470-18471 | NNP | denotes | ] |
T10942 | 18465-18470 | CD | denotes | 38-41 |
T10941 | 18464-18465 | NNP | denotes | [ |
T10940 | 18451-18463 | NNS | denotes | interactions |
T10939 | 18435-18450 | NN | denotes | protein-protein |
T10938 | 18426-18434 | JJ | denotes | specific |
T10937 | 18417-18425 | VBZ | denotes | disrupts |
T10936 | 18411-18416 | WDT | denotes | which |
T10935 | 18409-18410 | , | denotes | , |
T10934 | 18404-18409 | NNP | denotes | MALT1 |
T10933 | 18400-18403 | CC | denotes | and |
T10932 | 18394-18399 | NNP | denotes | TRAF6 |
T10931 | 18392-18393 | , | denotes | , |
T10930 | 18388-18392 | NNP | denotes | RIP2 |
T10929 | 18386-18387 | , | denotes | , |
T10928 | 18382-18386 | NNP | denotes | RIP1 |
T10927 | 18379-18381 | IN | denotes | as |
T10926 | 18374-18378 | JJ | denotes | such |
T10925 | 18372-18373 | , | denotes | , |
T10924 | 18363-18372 | NNS | denotes | molecules |
T10923 | 18352-18362 | VBG | denotes | signalling |
T10922 | 18346-18351 | NN | denotes | NF-κB |
T10921 | 18337-18345 | JJ | denotes | specific |
T10920 | 18320-18336 | VBG | denotes | deubiquitinating |
T10919 | 18317-18319 | IN | denotes | by |
T10918 | 18308-18316 | NN | denotes | function |
T10917 | 18302-18307 | JJ | denotes | NF-κB |
T10916 | 18294-18301 | VB | denotes | inhibit |
T10915 | 18291-18293 | TO | denotes | to |
T10914 | 18282-18290 | VBN | denotes | believed |
T10913 | 18279-18281 | VBZ | denotes | is |
T10912 | 18275-18278 | CD | denotes | A20 |
T10911 | 18273-18274 | . | denotes | . |
T10910 | 18272-18273 | -RRB- | denotes | ) |
T10909 | 18271-18272 | NNP | denotes | ] |
T10908 | 18269-18271 | CD | denotes | 37 |
T10907 | 18268-18269 | NNP | denotes | [ |
T10906 | 18265-18267 | IN | denotes | in |
T10905 | 18256-18264 | VBN | denotes | reviewed |
T10904 | 18255-18256 | -LRB- | denotes | ( |
T10903 | 18246-18254 | NN | denotes | receptor |
T10902 | 18244-18245 | CD | denotes | 2 |
T10901 | 18226-18243 | NN | denotes | domain-containing |
T10900 | 18210-18225 | NN | denotes | oligomerisation |
T10899 | 18191-18209 | JJ | denotes | nucleotide-binding |
T10898 | 18187-18190 | DT | denotes | the |
T10897 | 18183-18186 | CC | denotes | and |
T10896 | 18178-18182 | NNS | denotes | TLRs |
T10895 | 18175-18177 | IN | denotes | of |
T10894 | 18164-18174 | VBG | denotes | triggering |
T10893 | 18160-18163 | DT | denotes | the |
T10892 | 18156-18159 | CC | denotes | and |
T10891 | 18154-18155 | , | denotes | , |
T10890 | 18146-18154 | NNS | denotes | antigens |
T10889 | 18142-18145 | CC | denotes | and |
T10888 | 18137-18141 | NNP | denotes | IL-1 |
T10887 | 18135-18136 | , | denotes | , |
T10886 | 18132-18135 | NNP | denotes | TNF |
T10885 | 18122-18131 | VBG | denotes | including |
T10884 | 18120-18121 | , | denotes | , |
T10883 | 18113-18120 | NNS | denotes | stimuli |
T10882 | 18095-18112 | JJ | denotes | immune-activating |
T10881 | 18085-18094 | JJ | denotes | different |
T10880 | 18082-18084 | TO | denotes | to |
T10879 | 18073-18081 | NN | denotes | response |
T10878 | 18070-18072 | IN | denotes | in |
T10877 | 18059-18069 | NN | denotes | expression |
T10876 | 18054-18058 | NN | denotes | gene |
T10875 | 18038-18053 | JJ | denotes | NF-κB-dependent |
T10874 | 18028-18037 | VBZ | denotes | regulates |
T10873 | 18017-18027 | RB | denotes | negatively |
T10872 | 18012-18016 | WDT | denotes | that |
T10871 | 18004-18011 | NN | denotes | protein |
T10870 | 17986-18003 | JJ | denotes | ubiquitin-editing |
T10869 | 17984-17985 | DT | denotes | a |
T10868 | 17981-17983 | VBZ | denotes | is |
T10867 | 17979-17980 | -RRB- | denotes | ) |
T10866 | 17972-17979 | CD | denotes | TNFAIP3 |
T10865 | 17969-17971 | IN | denotes | as |
T9023 | 17363-17372 | VBD | denotes | increased |
T9022 | 17358-17362 | NN | denotes | show |
T9021 | 17353-17357 | NNP | denotes | IKK1 |
T9020 | 17344-17352 | JJ | denotes | inactive |
T9019 | 17333-17343 | VBG | denotes | expressing |
T9018 | 17328-17332 | NNS | denotes | mice |
T9017 | 17320-17327 | VB | denotes | knockin |
T9016 | 17317-17319 | CC | denotes | or |
T9015 | 17312-17316 | NNS | denotes | mice |
T9014 | 17297-17311 | JJ | denotes | IKK1-deficient |
T9013 | 17292-17296 | IN | denotes | from |
T9012 | 17280-17291 | NNS | denotes | Macrophages |
T9011 | 17278-17279 | . | denotes | . |
T9010 | 17270-17278 | NNS | denotes | pathways |
T9009 | 17264-17269 | NN | denotes | NF-κB |
T9008 | 17251-17263 | JJ | denotes | noncanonical |
T9007 | 17247-17250 | CC | denotes | and |
T9006 | 17237-17246 | JJ | denotes | canonical |
T9005 | 17232-17236 | DT | denotes | both |
T9004 | 17229-17231 | IN | denotes | of |
T9003 | 17218-17228 | NN | denotes | regulation |
T9002 | 17209-17217 | JJ | denotes | negative |
T9001 | 17205-17208 | DT | denotes | the |
T9000 | 17202-17204 | IN | denotes | in |
T8999 | 17197-17201 | NN | denotes | role |
T8998 | 17187-17196 | JJ | denotes | prominent |
T8997 | 17185-17186 | DT | denotes | a |
T8996 | 17179-17184 | VBZ | denotes | plays |
T8995 | 17174-17178 | RB | denotes | also |
T8994 | 17167-17173 | NN | denotes | kinase |
T8993 | 17162-17166 | DT | denotes | this |
T8992 | 17157-17161 | IN | denotes | that |
T8991 | 17147-17156 | VBN | denotes | mentioned |
T8990 | 17144-17146 | VB | denotes | be |
T8989 | 17137-17143 | MD | denotes | should |
T8988 | 17134-17136 | PRP | denotes | it |
T8987 | 17132-17133 | , | denotes | , |
T8986 | 17125-17132 | NN | denotes | pathway |
T8985 | 17119-17124 | NN | denotes | NF-κB |
T8984 | 17105-17118 | JJ | denotes | non-canonical |
T8983 | 17101-17104 | DT | denotes | the |
T8982 | 17098-17100 | IN | denotes | of |
T8981 | 17088-17097 | NN | denotes | component |
T8980 | 17079-17087 | JJ | denotes | critical |
T8979 | 17077-17078 | DT | denotes | a |
T8978 | 17074-17076 | VBZ | denotes | is |
T8977 | 17069-17073 | NNP | denotes | IKK1 |
T8976 | 17050-17068 | JJ | denotes | reported. Although |
T8975 | 17045-17049 | VBN | denotes | been |
T8974 | 17041-17044 | RB | denotes | yet |
T8973 | 17037-17040 | RB | denotes | not |
T8972 | 17033-17036 | VBZ | denotes | has |
T8971 | 17023-17032 | NN | denotes | pathology |
T8970 | 17020-17022 | NNP | denotes | RA |
T8969 | 17015-17019 | IN | denotes | with |
T8968 | 17010-17014 | NN | denotes | link |
T8967 | 17008-17009 | DT | denotes | a |
T8966 | 17002-17007 | IN | denotes | since |
T8965 | 17000-17001 | , | denotes | , |
T8964 | 16996-17000 | RB | denotes | here |
T8963 | 16986-16995 | VBN | denotes | discussed |
T8962 | 16982-16985 | RB | denotes | not |
T8961 | 16978-16981 | VBP | denotes | are |
T8960 | 16969-16977 | NNS | denotes | proteins |
T8959 | 16963-16968 | DT | denotes | These |
T8958 | 16961-16962 | . | denotes | . |
T8957 | 16960-16961 | -RRB- | denotes | ) |
T8956 | 16959-16960 | NNP | denotes | ] |
T8955 | 16957-16959 | CD | denotes | 33 |
T8954 | 16956-16957 | NNP | denotes | [ |
T8953 | 16953-16955 | IN | denotes | in |
T8952 | 16944-16952 | VBN | denotes | reviewed |
T8951 | 16943-16944 | -LRB- | denotes | ( |
T8950 | 16933-16942 | VBN | denotes | described |
T8949 | 16928-16932 | VBN | denotes | been |
T8948 | 16923-16927 | VBP | denotes | have |
T8947 | 16921-16922 | , | denotes | , |
T8946 | 16915-16921 | NNP | denotes | TOLLIP |
T8945 | 16911-16914 | CC | denotes | and |
T8944 | 16909-16910 | , | denotes | , |
T8943 | 16903-16909 | NNP | denotes | IRAK-M |
T8942 | 16901-16902 | , | denotes | , |
T8941 | 16895-16901 | NNS | denotes | MyD88s |
T8940 | 16892-16894 | IN | denotes | as |
T8939 | 16887-16891 | JJ | denotes | such |
T8938 | 16885-16886 | , | denotes | , |
T8937 | 16876-16885 | NNS | denotes | responses |
T8936 | 16863-16875 | JJ | denotes | inflammatory |
T8935 | 16847-16862 | JJ | denotes | NF-κB-dependent |
T8934 | 16844-16846 | IN | denotes | of |
T8933 | 16833-16843 | NN | denotes | regulation |
T8932 | 16824-16832 | JJ | denotes | negative |
T8931 | 16820-16823 | DT | denotes | the |
T8930 | 16817-16819 | IN | denotes | in |
T8929 | 16808-16816 | VBN | denotes | involved |
T8928 | 16799-16807 | NNS | denotes | proteins |
T8927 | 16793-16798 | JJ | denotes | other |
T8926 | 16785-16792 | JJ | denotes | Several |
T8925 | 16783-16784 | . | denotes | . |
T8924 | 16781-16783 | NNP | denotes | RA |
T8923 | 16778-16780 | IN | denotes | of |
T8922 | 16762-16777 | NN | denotes | immunopathology |
T8921 | 16758-16761 | DT | denotes | the |
T8920 | 16755-16757 | IN | denotes | in |
T8919 | 16747-16754 | NNS | denotes | factors |
T8918 | 16736-16746 | NN | denotes | inhibitory |
T8917 | 16730-16735 | JJ | denotes | NF-κB |
T8916 | 16724-16729 | DT | denotes | these |
T8915 | 16721-16723 | IN | denotes | of |
T8914 | 16716-16720 | NN | denotes | role |
T8913 | 16706-16715 | JJ | denotes | potential |
T8912 | 16702-16705 | DT | denotes | the |
T8911 | 16694-16701 | VBP | denotes | discuss |
T8910 | 16691-16693 | PRP | denotes | we |
T8909 | 16689-16690 | , | denotes | , |
T8908 | 16681-16689 | NN | denotes | addition |
T8907 | 16678-16680 | IN | denotes | In |
T8906 | 16676-16677 | . | denotes | . |
T8905 | 16672-16676 | NN | denotes | loop |
T8904 | 16663-16671 | NN | denotes | feedback |
T8903 | 16654-16662 | JJ | denotes | negative |
T8902 | 16652-16653 | DT | denotes | a |
T8901 | 16649-16651 | IN | denotes | in |
T8900 | 16642-16648 | VBG | denotes | acting |
T8899 | 16637-16641 | RB | denotes | thus |
T8898 | 16633-16636 | CC | denotes | and |
T8897 | 16626-16632 | PRP | denotes | itself |
T8896 | 16620-16625 | JJ | denotes | NF-κB |
T8895 | 16617-16619 | IN | denotes | of |
T8894 | 16609-16616 | NN | denotes | control |
T8893 | 16605-16608 | DT | denotes | the |
T8892 | 16599-16604 | IN | denotes | under |
T8891 | 16594-16598 | PRP | denotes | them |
T8890 | 16591-16593 | IN | denotes | of |
T8889 | 16586-16590 | DT | denotes | some |
T8888 | 16584-16585 | , | denotes | , |
T8887 | 16576-16584 | NN | denotes | response |
T8886 | 16570-16575 | NNP | denotes | NF-κB |
T8885 | 16566-16569 | DT | denotes | the |
T8884 | 16563-16565 | IN | denotes | of |
T8883 | 16551-16562 | NN | denotes | termination |
T8882 | 16548-16550 | CC | denotes | or |
T8881 | 16538-16547 | NN | denotes | dampening |
T8880 | 16534-16537 | DT | denotes | the |
T8879 | 16531-16533 | IN | denotes | in |
T8878 | 16522-16530 | VBN | denotes | involved |
T8877 | 16518-16521 | VBP | denotes | are |
T8876 | 16513-16517 | WDT | denotes | that |
T8875 | 16504-16512 | NNS | denotes | proteins |
T8874 | 16501-16503 | IN | denotes | of |
T8873 | 16494-16500 | NN | denotes | number |
T8872 | 16492-16493 | DT | denotes | a |
T8871 | 16489-16491 | IN | denotes | of |
T8870 | 16480-16488 | NN | denotes | overview |
T8869 | 16477-16479 | DT | denotes | an |
T8868 | 16472-16476 | VBP | denotes | give |
T8867 | 16469-16471 | PRP | denotes | we |
T8866 | 16463-16468 | IN | denotes | Below |
T8865 | 16461-16462 | . | denotes | . |
T8864 | 16460-16461 | NNP | denotes | ] |
T8863 | 16458-16460 | CD | denotes | 32 |
T8862 | 16457-16458 | NNP | denotes | [ |
T8861 | 16446-16456 | JJ | denotes | signalling |
T8860 | 16440-16445 | JJ | denotes | NF-κB |
T8859 | 16427-16439 | VBP | denotes | downregulate |
T8858 | 16422-16426 | WDT | denotes | that |
T8857 | 16413-16421 | NNS | denotes | proteins |
T8856 | 16402-16412 | JJ | denotes | inhibitory |
T8855 | 16399-16401 | IN | denotes | of |
T8854 | 16388-16398 | NN | denotes | expression |
T8853 | 16384-16387 | DT | denotes | the |
T8852 | 16374-16383 | VBG | denotes | including |
T8851 | 16372-16373 | , | denotes | , |
T8850 | 16362-16372 | NNS | denotes | mechanisms |
T8849 | 16352-16361 | JJ | denotes | different |
T8848 | 16345-16351 | VBP | denotes | employ |
T8847 | 16339-16344 | NNS | denotes | cells |
T8846 | 16337-16338 | , | denotes | , |
T8845 | 16333-16337 | DT | denotes | this |
T8844 | 16325-16332 | VB | denotes | achieve |
T8843 | 16322-16324 | TO | denotes | To |
T8842 | 16320-16321 | . | denotes | . |
T8841 | 16307-16320 | NN | denotes | tumorigenesis |
T8840 | 16300-16306 | CC | denotes | and/or |
T8839 | 16287-16299 | NN | denotes | inflammation |
T8838 | 16279-16286 | JJ | denotes | chronic |
T8837 | 16276-16278 | TO | denotes | to |
T8836 | 16271-16275 | VB | denotes | lead |
T8835 | 16267-16270 | MD | denotes | may |
T8834 | 16262-16266 | WDT | denotes | that |
T8833 | 16251-16261 | NN | denotes | activation |
T8832 | 16245-16250 | NN | denotes | NF-κB |
T8831 | 16234-16244 | JJ | denotes | persistent |
T8830 | 16226-16233 | VB | denotes | prevent |
T8829 | 16223-16225 | TO | denotes | to |
T8828 | 16213-16222 | JJ | denotes | essential |
T8827 | 16210-16212 | VBZ | denotes | is |
T8826 | 16201-16209 | NN | denotes | response |
T8825 | 16195-16200 | JJ | denotes | NF-κB |
T8824 | 16192-16194 | DT | denotes | an |
T8823 | 16180-16191 | VBG | denotes | terminating |
T8822 | 16178-16179 | , | denotes | , |
T8821 | 16170-16178 | RB | denotes | Moreover |
T8820 | 16168-16169 | . | denotes | . |
T8819 | 16160-16168 | NN | denotes | response |
T8818 | 16147-16159 | JJ | denotes | inflammatory |
T8817 | 16143-16146 | DT | denotes | the |
T8816 | 16133-16142 | VB | denotes | fine-tune |
T8815 | 16130-16132 | TO | denotes | to |
T8814 | 16118-16129 | NN | denotes | requirement |
T8813 | 16109-16117 | JJ | denotes | absolute |
T8812 | 16106-16108 | DT | denotes | an |
T8811 | 16103-16105 | VBZ | denotes | is |
T8810 | 16095-16102 | VBZ | denotes | induces |
T8809 | 16092-16094 | PRP | denotes | it |
T8808 | 16086-16091 | NNS | denotes | genes |
T9112 | 17938-17939 | . | denotes | . |
T9111 | 17936-17938 | NNP | denotes | RA |
T9110 | 17931-17935 | IN | denotes | like |
T9109 | 17922-17930 | NNS | denotes | diseases |
T9108 | 17909-17921 | JJ | denotes | inflammatory |
T9107 | 17901-17908 | JJ | denotes | chronic |
T9106 | 17897-17900 | IN | denotes | for |
T9105 | 17884-17896 | NNS | denotes | implications |
T9104 | 17875-17883 | JJ | denotes | possible |
T9103 | 17870-17874 | IN | denotes | with |
T9102 | 17861-17869 | NNS | denotes | pathways |
T9101 | 17855-17860 | NN | denotes | NF-κB |
T9100 | 17842-17854 | JJ | denotes | noncanonical |
T9099 | 17838-17841 | CC | denotes | and |
T9098 | 17828-17837 | JJ | denotes | canonical |
T9097 | 17823-17827 | DT | denotes | both |
T9096 | 17811-17822 | VBG | denotes | terminating |
T9095 | 17808-17810 | IN | denotes | in |
T9094 | 17802-17807 | NNS | denotes | roles |
T9093 | 17792-17801 | JJ | denotes | important |
T9092 | 17786-17791 | VBZ | denotes | plays |
T9091 | 17781-17785 | NNP | denotes | IKK1 |
T9090 | 17776-17780 | WDT | denotes | that |
T9089 | 17771-17775 | NN | denotes | idea |
T9088 | 17767-17770 | DT | denotes | the |
T9087 | 17756-17766 | VBG | denotes | supporting |
T9086 | 17754-17755 | , | denotes | , |
T9085 | 17753-17754 | NNP | denotes | ] |
T9084 | 17751-17753 | CD | denotes | 36 |
T9083 | 17750-17751 | NNP | denotes | [ |
T9082 | 17742-17749 | NN | denotes | pathway |
T9081 | 17736-17741 | NN | denotes | NF-κB |
T9080 | 17723-17735 | JJ | denotes | noncanonical |
T9079 | 17719-17722 | DT | denotes | the |
T9078 | 17716-17718 | IN | denotes | of |
T9077 | 17705-17715 | NN | denotes | regulation |
T9076 | 17696-17704 | NN | denotes | feedback |
T9075 | 17687-17695 | JJ | denotes | negative |
T9074 | 17684-17686 | IN | denotes | in |
T9073 | 17680-17683 | NNP | denotes | NIK |
T9072 | 17665-17679 | NNS | denotes | phosphorylates |
T9071 | 17660-17664 | CD | denotes | IKK1 |
T9070 | 17655-17659 | IN | denotes | that |
T9069 | 17642-17654 | VBN | denotes | demonstrated |
T9068 | 17638-17641 | VBZ | denotes | has |
T9067 | 17632-17637 | NN | denotes | study |
T9066 | 17625-17631 | JJ | denotes | recent |
T9065 | 17623-17624 | DT | denotes | a |
T9064 | 17621-17622 | , | denotes | , |
T9063 | 17608-17621 | RB | denotes | Interestingly |
T9062 | 17606-17607 | . | denotes | . |
T9061 | 17605-17606 | NNP | denotes | ] |
T9060 | 17603-17605 | CD | denotes | 35 |
T9059 | 17602-17603 | NNP | denotes | [ |
T9058 | 17596-17601 | NNP | denotes | STAT1 |
T9057 | 17580-17595 | VBG | denotes | phosphorylating |
T9056 | 17577-17579 | IN | denotes | by |
T9055 | 17566-17576 | NN | denotes | signalling |
T9054 | 17550-17565 | JJ | denotes | proinflammatory |
T9053 | 17537-17549 | VB | denotes | downregulate |
T9052 | 17534-17536 | TO | denotes | to |
T9051 | 17530-17533 | CC | denotes | and |
T9050 | 17524-17529 | NN | denotes | NF-κB |
T9049 | 17516-17523 | JJ | denotes | nuclear |
T9048 | 17508-17515 | VB | denotes | inhibit |
T9047 | 17505-17507 | TO | denotes | to |
T9046 | 17499-17504 | VBN | denotes | shown |
T9045 | 17494-17498 | VBN | denotes | been |
T9044 | 17489-17493 | RB | denotes | also |
T9043 | 17485-17488 | VBZ | denotes | has |
T9042 | 17480-17484 | CD | denotes | IKK1 |
T9041 | 17478-17479 | . | denotes | . |
T9040 | 17477-17478 | NNP | denotes | ] |
T9039 | 17475-17477 | CD | denotes | 34 |
T9038 | 17474-17475 | NNP | denotes | [ |
T9037 | 17462-17473 | NN | denotes | degradation |
T9036 | 17457-17461 | NNP | denotes | IκBα |
T9035 | 17453-17456 | CC | denotes | and |
T9034 | 17442-17452 | NN | denotes | activation |
T9033 | 17437-17441 | NNP | denotes | IKK2 |
T9032 | 17428-17436 | JJ | denotes | enhanced |
T9031 | 17425-17427 | IN | denotes | of |
T9030 | 17418-17424 | NN | denotes | result |
T9029 | 17416-17417 | DT | denotes | a |
T9028 | 17413-17415 | IN | denotes | as |
T9027 | 17403-17412 | NNS | denotes | cytokines |
T9026 | 17387-17402 | JJ | denotes | proinflammatory |
T9025 | 17384-17386 | IN | denotes | of |
T9024 | 17373-17383 | NN | denotes | production |
T8807 | 16082-16085 | DT | denotes | the |
T8806 | 16078-16081 | CC | denotes | and |
T8805 | 16070-16077 | NN | denotes | pathway |
T8804 | 16059-16069 | VBG | denotes | signalling |
T8803 | 16053-16058 | NN | denotes | NF-κB |
T8802 | 16049-16052 | DT | denotes | the |
T8801 | 16046-16048 | IN | denotes | of |
T8800 | 16035-16045 | NN | denotes | regulation |
T8799 | 16029-16034 | JJ | denotes | tight |
T8798 | 16027-16028 | DT | denotes | a |
T8797 | 16025-16026 | , | denotes | , |
T8796 | 16016-16025 | NNS | denotes | processes |
T8795 | 16007-16015 | JJ | denotes | cellular |
T8794 | 16002-16006 | JJ | denotes | many |
T8793 | 15999-16001 | TO | denotes | to |
T8792 | 15991-15998 | JJ | denotes | crucial |
T8791 | 15988-15990 | RB | denotes | so |
T8790 | 15985-15987 | VBZ | denotes | is |
T8789 | 15974-15984 | NN | denotes | activation |
T8788 | 15968-15973 | NNP | denotes | NF-κB |
T8787 | 15962-15967 | IN | denotes | Since |
T6864 | 15913-15914 | . | denotes | . |
T6863 | 15912-15913 | NNP | denotes | ] |
T6862 | 15907-15912 | CD | denotes | 30,31 |
T6861 | 15906-15907 | NNP | denotes | [ |
T6860 | 15895-15905 | VBG | denotes | signalling |
T6859 | 15890-15894 | NNP | denotes | CD40 |
T6858 | 15887-15889 | IN | denotes | of |
T6857 | 15877-15886 | NN | denotes | regulator |
T6856 | 15868-15876 | JJ | denotes | negative |
T6855 | 15866-15867 | DT | denotes | a |
T6854 | 15863-15865 | IN | denotes | as |
T6853 | 15856-15862 | VBZ | denotes | serves |
T6852 | 15850-15855 | CD | denotes | TRAF3 |
T6851 | 15846-15849 | CC | denotes | and |
T6850 | 15844-15845 | , | denotes | , |
T6849 | 15839-15844 | NNP | denotes | NF-κB |
T6848 | 15836-15838 | IN | denotes | of |
T6847 | 15825-15835 | NN | denotes | activation |
T6846 | 15821-15824 | IN | denotes | for |
T6845 | 15812-15820 | VBN | denotes | required |
T6844 | 15809-15811 | VBZ | denotes | is |
T6843 | 15803-15808 | CD | denotes | TRAF2 |
T6842 | 15797-15802 | IN | denotes | while |
T6841 | 15795-15796 | , | denotes | , |
T6840 | 15785-15795 | NN | denotes | production |
T6839 | 15780-15784 | NN | denotes | IL-6 |
T6838 | 15776-15779 | CC | denotes | and |
T6837 | 15765-15775 | NN | denotes | activation |
T6836 | 15761-15764 | NNP | denotes | JNK |
T6835 | 15747-15760 | JJ | denotes | CD40-mediated |
T6834 | 15743-15746 | IN | denotes | for |
T6833 | 15734-15742 | VBN | denotes | required |
T6832 | 15731-15733 | VBZ | denotes | is |
T6831 | 15725-15730 | NNP | denotes | TRAF6 |
T6830 | 15719-15724 | NNS | denotes | cells |
T6829 | 15717-15718 | NNP | denotes | B |
T6828 | 15714-15716 | IN | denotes | in |
T6827 | 15712-15713 | , | denotes | , |
T6826 | 15705-15712 | NN | denotes | example |
T6825 | 15701-15704 | IN | denotes | For |
T6824 | 15699-15700 | . | denotes | . |
T6823 | 15690-15699 | NNS | denotes | functions |
T6822 | 15676-15689 | JJ | denotes | CD40-mediated |
T6821 | 15667-15675 | JJ | denotes | distinct |
T6820 | 15663-15666 | CC | denotes | and |
T6819 | 15651-15662 | VBG | denotes | overlapping |
T6818 | 15646-15650 | IN | denotes | with |
T6817 | 15635-15645 | VBN | denotes | associated |
T6816 | 15631-15634 | VBP | denotes | are |
T6815 | 15621-15630 | NNS | denotes | molecules |
T6814 | 15616-15620 | NNP | denotes | TRAF |
T6813 | 15607-15615 | JJ | denotes | Specific |
T6812 | 15605-15606 | . | denotes | . |
T6811 | 15600-15605 | IN | denotes | above |
T6810 | 15590-15599 | VBN | denotes | described |
T6809 | 15587-15589 | IN | denotes | as |
T6808 | 15579-15586 | NN | denotes | pathway |
T6807 | 15566-15578 | JJ | denotes | noncanonical |
T6806 | 15562-15565 | DT | denotes | the |
T6805 | 15559-15561 | IN | denotes | of |
T6804 | 15548-15558 | NN | denotes | activation |
T6803 | 15544-15547 | DT | denotes | the |
T6802 | 15541-15543 | IN | denotes | in |
T6801 | 15536-15540 | NN | denotes | step |
T6800 | 15526-15535 | JJ | denotes | important |
T6799 | 15523-15525 | DT | denotes | an |
T6798 | 15512-15522 | VBZ | denotes | represents |
T6797 | 15506-15511 | WDT | denotes | which |
T6796 | 15504-15505 | , | denotes | , |
T6795 | 15499-15504 | CD | denotes | TRAF3 |
T6794 | 15495-15498 | CC | denotes | and |
T6793 | 15489-15494 | CD | denotes | TRAF2 |
T6792 | 15484-15488 | DT | denotes | both |
T6791 | 15481-15483 | IN | denotes | of |
T6790 | 15469-15480 | NN | denotes | proteolysis |
T6789 | 15465-15468 | DT | denotes | the |
T6788 | 15462-15464 | TO | denotes | to |
T6787 | 15456-15461 | VBZ | denotes | leads |
T6786 | 15451-15455 | DT | denotes | this |
T6785 | 15447-15450 | CC | denotes | and |
T6784 | 15445-15446 | , | denotes | , |
T6783 | 15440-15445 | NNP | denotes | TRAF6 |
T6782 | 15436-15439 | CC | denotes | and |
T6781 | 15434-15435 | , | denotes | , |
T6780 | 15429-15434 | CD | denotes | TRAF5 |
T6779 | 15427-15428 | , | denotes | , |
T6778 | 15422-15427 | CD | denotes | TRAF3 |
T6777 | 15420-15421 | , | denotes | , |
T6776 | 15415-15420 | CD | denotes | TRAF2 |
T6775 | 15413-15414 | , | denotes | , |
T6774 | 15408-15413 | CD | denotes | TRAF1 |
T6773 | 15398-15407 | VBG | denotes | including |
T6772 | 15396-15397 | , | denotes | , |
T6771 | 15389-15396 | NNS | denotes | members |
T6770 | 15384-15388 | NNP | denotes | TRAF |
T6769 | 15376-15383 | JJ | denotes | several |
T6768 | 15371-15375 | IN | denotes | with |
T6767 | 15362-15370 | NN | denotes | interact |
T6766 | 15357-15361 | NNP | denotes | RANK |
T6765 | 15353-15356 | CC | denotes | and |
T6764 | 15348-15352 | NNP | denotes | CD40 |
T6763 | 15346-15347 | , | denotes | , |
T6762 | 15340-15346 | NN | denotes | ligand |
T6761 | 15334-15339 | PRP$ | denotes | their |
T6760 | 15331-15333 | IN | denotes | of |
T6759 | 15323-15330 | JJ | denotes | binding |
T6758 | 15318-15322 | IN | denotes | Upon |
T6757 | 15316-15317 | . | denotes | . |
T6756 | 15308-15316 | NNS | denotes | pathways |
T6755 | 15297-15307 | VBG | denotes | signalling |
T6754 | 15291-15296 | NN | denotes | NF-κB |
T6753 | 15278-15290 | JJ | denotes | noncanonical |
T6752 | 15274-15277 | CC | denotes | and |
T6751 | 15264-15273 | JJ | denotes | canonical |
T6750 | 15259-15263 | DT | denotes | both |
T6749 | 15256-15258 | IN | denotes | of |
T6748 | 15245-15255 | NN | denotes | activation |
T6747 | 15241-15244 | DT | denotes | the |
T6746 | 15233-15240 | VB | denotes | mediate |
T6745 | 15228-15232 | VB | denotes | RANK |
T6744 | 15224-15227 | CC | denotes | and |
T6743 | 15215-15223 | NN | denotes | receptor |
T6742 | 15213-15214 | NN | denotes | β |
T6741 | 15201-15212 | NN | denotes | lymphotoxin |
T6740 | 15199-15200 | , | denotes | , |
T6739 | 15195-15199 | NNP | denotes | CD40 |
T6738 | 15190-15194 | IN | denotes | that |
T6737 | 15180-15189 | VBN | denotes | mentioned |
T6736 | 15177-15179 | VB | denotes | be |
T6735 | 15170-15176 | MD | denotes | should |
T6734 | 15167-15169 | PRP | denotes | It |
T6733 | 13837-13838 | . | denotes | . |
T6732 | 13836-13837 | -RRB- | denotes | ) |
T6731 | 13835-13836 | CD | denotes | 2 |
T6730 | 13828-13834 | NNP | denotes | Figure |
T6729 | 13827-13828 | -LRB- | denotes | ( |
T6728 | 13825-13826 | NNP | denotes | ] |
T6727 | 13820-13825 | CD | denotes | 28,29 |
T6726 | 13819-13820 | NNP | denotes | [ |
T6725 | 13803-13818 | NN | denotes | phosphorylation |
T6724 | 13798-13802 | CD | denotes | IKK1 |
T6723 | 13794-13797 | CC | denotes | and |
T6722 | 13781-13793 | NN | denotes | accumulation |
T6721 | 13777-13780 | NNP | denotes | NIK |
T6720 | 13774-13776 | IN | denotes | in |
T6719 | 13764-13773 | VBG | denotes | resulting |
T6718 | 13762-13763 | , | denotes | , |
T6717 | 13751-13762 | NN | denotes | degradation |
T6716 | 13738-13750 | JJ | denotes | constitutive |
T6715 | 13734-13737 | PRP$ | denotes | its |
T6714 | 13729-13733 | IN | denotes | from |
T6713 | 13725-13728 | NNP | denotes | NIK |
T6712 | 13715-13724 | VBG | denotes | releasing |
T6711 | 13712-13714 | TO | denotes | to |
T6710 | 13700-13711 | VBZ | denotes | contributes |
T6709 | 13695-13699 | DT | denotes | this |
T6708 | 13691-13694 | PDT | denotes | All |
T6707 | 13689-13690 | . | denotes | . |
T6706 | 13678-13689 | NN | denotes | degradation |
T6705 | 13672-13677 | CD | denotes | TRAF3 |
T6704 | 13661-13671 | JJ | denotes | subsequent |
T6703 | 13657-13660 | IN | denotes | for |
T6702 | 13647-13656 | JJ | denotes | essential |
T6701 | 13643-13646 | VBP | denotes | are |
T6700 | 13637-13642 | WDT | denotes | which |
T6699 | 13635-13636 | , | denotes | , |
T6698 | 13628-13635 | NNP | denotes | cIAP1/2 |
T6691 | 13596-13597 | , | denotes | , |
T6690 | 13588-13596 | NN | denotes | receptor |
T6689 | 13584-13587 | DT | denotes | the |
T6688 | 13581-13583 | TO | denotes | to |
T6687 | 13578-13580 | PRP | denotes | it |
T6686 | 13567-13577 | VBG | denotes | recruiting |
T6685 | 13564-13566 | IN | denotes | by |
T6684 | 13556-13563 | JJ | denotes | complex |
T6683 | 13551-13555 | DT | denotes | this |
T6682 | 13546-13550 | IN | denotes | from |
T6681 | 13540-13545 | CD | denotes | TRAF3 |
T6680 | 13533-13539 | VB | denotes | remove |
T6679 | 13530-13532 | TO | denotes | to |
T6678 | 13525-13529 | RB | denotes | only |
T6677 | 13521-13524 | RB | denotes | not |
T6676 | 13515-13520 | VBN | denotes | shown |
T6675 | 13510-13514 | VBN | denotes | been |
T6674 | 13506-13509 | VBZ | denotes | has |
T6673 | 13497-13505 | NN | denotes | ligation |
T6672 | 13488-13496 | NN | denotes | Receptor |
T6671 | 13486-13487 | . | denotes | . |
T6670 | 13476-13486 | JJ | denotes | proteasome |
T6669 | 13472-13475 | DT | denotes | the |
T6668 | 13469-13471 | IN | denotes | by |
T6667 | 13457-13468 | NN | denotes | degradation |
T6666 | 13446-13456 | JJ | denotes | continuous |
T6665 | 13442-13445 | PRP$ | denotes | its |
T6664 | 13439-13441 | TO | denotes | to |
T6663 | 13431-13438 | VBG | denotes | leading |
T6662 | 13429-13430 | , | denotes | , |
T6661 | 13426-13429 | NNP | denotes | NIK |
T6660 | 13404-13425 | VBZ | denotes | K48-polyubiquitinates |
T6659 | 13398-13403 | WDT | denotes | which |
T6658 | 13396-13397 | , | denotes | , |
T6657 | 13389-13396 | NNP | denotes | cIAP1/2 |
T6656 | 13385-13388 | CC | denotes | and |
T6655 | 13383-13384 | , | denotes | , |
T6654 | 13378-13383 | CD | denotes | TRAF3 |
T6653 | 13376-13377 | , | denotes | , |
T6652 | 13371-13376 | CD | denotes | TRAF2 |
T6651 | 13366-13370 | IN | denotes | with |
T6650 | 13358-13365 | NN | denotes | complex |
T6649 | 13346-13357 | JJ | denotes | cytoplasmic |
T6648 | 13344-13345 | DT | denotes | a |
T6647 | 13341-13343 | IN | denotes | in |
T6646 | 13334-13340 | VBZ | denotes | occurs |
T6645 | 13330-13333 | NNP | denotes | NIK |
T6644 | 13328-13329 | , | denotes | , |
T6643 | 13323-13328 | NNS | denotes | cells |
T6642 | 13310-13322 | JJ | denotes | unstimulated |
T6641 | 13307-13309 | IN | denotes | In |
T6640 | 13305-13306 | . | denotes | . |
T6639 | 13300-13305 | NNS | denotes | types |
T6638 | 13295-13299 | NN | denotes | cell |
T6637 | 13290-13294 | JJS | denotes | most |
T6636 | 13287-13289 | IN | denotes | in |
T6635 | 13280-13286 | NNS | denotes | levels |
T6634 | 13276-13279 | JJ | denotes | low |
T6633 | 13266-13275 | RB | denotes | extremely |
T6632 | 13263-13265 | IN | denotes | at |
T6631 | 13255-13262 | JJ | denotes | present |
T6630 | 13252-13254 | VBZ | denotes | is |
T6629 | 13248-13251 | CC | denotes | and |
T6628 | 13242-13247 | NN | denotes | level |
T6627 | 13223-13241 | JJ | denotes | post-translational |
T6626 | 13219-13222 | DT | denotes | the |
T6625 | 13216-13218 | IN | denotes | at |
T6624 | 13206-13215 | VBN | denotes | regulated |
T6623 | 13192-13205 | RB | denotes | predominantly |
T6622 | 13189-13191 | VBZ | denotes | is |
T6621 | 13185-13188 | NNP | denotes | NIK |
T6620 | 13183-13184 | . | denotes | . |
T6619 | 13182-13183 | -RRB- | denotes | ) |
T6618 | 13179-13182 | NNP | denotes | NIK |
T6617 | 13178-13179 | -LRB- | denotes | ( |
T6616 | 13171-13177 | NN | denotes | kinase |
T6615 | 13162-13170 | VBG | denotes | inducing |
T6614 | 13156-13161 | JJ | denotes | NF-κB |
T6613 | 13153-13155 | IN | denotes | by |
T6612 | 13137-13152 | NN | denotes | phosphorylation |
T6611 | 13132-13136 | IN | denotes | upon |
T6610 | 13122-13131 | VBN | denotes | activated |
T6609 | 13119-13121 | VBZ | denotes | is |
T6608 | 13113-13118 | WDT | denotes | which |
T6607 | 13111-13112 | , | denotes | , |
T6606 | 13107-13111 | NNP | denotes | IKK1 |
T6605 | 13104-13106 | IN | denotes | on |
T6604 | 13094-13103 | JJ | denotes | dependent |
T6603 | 13085-13093 | RB | denotes | strictly |
T6602 | 13082-13084 | VBZ | denotes | is |
T6601 | 13074-13081 | NN | denotes | pathway |
T6600 | 13068-13073 | NN | denotes | NF-κB |
T6599 | 13055-13067 | JJ | denotes | noncanonical |
T6598 | 13051-13054 | DT | denotes | The |
T6597 | 13049-13050 | NNP | denotes | ] |
T6596 | 13047-13049 | CD | denotes | 27 |
T6595 | 13046-13047 | NNP | denotes | [ |
T6594 | 13027-13045 | NN | denotes | osteoclastogenesis |
T6593 | 13023-13026 | CC | denotes | and |
T6592 | 13021-13022 | , | denotes | , |
T6591 | 13010-13021 | NN | denotes | development |
T6590 | 13004-13009 | NN | denotes | organ |
T6589 | 12995-13003 | JJ | denotes | lymphoid |
T6588 | 12985-12994 | JJ | denotes | secondary |
T6587 | 12983-12984 | , | denotes | , |
T6586 | 12972-12983 | NN | denotes | development |
T6585 | 12965-12971 | JJ | denotes | B-cell |
T6584 | 12957-12964 | VBP | denotes | control |
T6583 | 12952-12956 | WDT | denotes | that |
T6582 | 12946-12951 | NNS | denotes | genes |
T6581 | 12939-12945 | NN | denotes | target |
T6580 | 12936-12938 | IN | denotes | of |
T6579 | 12932-12935 | NN | denotes | set |
T6578 | 12923-12931 | JJ | denotes | distinct |
T6577 | 12921-12922 | DT | denotes | a |
T6576 | 12911-12920 | VBZ | denotes | regulates |
T6575 | 12903-12910 | NN | denotes | subunit |
T6574 | 12897-12902 | NNP | denotes | NF-κB |
T6573 | 12892-12896 | NNP | denotes | RelB |
T6572 | 12888-12891 | DT | denotes | the |
T6571 | 12883-12887 | IN | denotes | with |
T6570 | 12874-12882 | RB | denotes | together |
T6569 | 12868-12873 | WDT | denotes | which |
T6568 | 12866-12867 | , | denotes | , |
T6567 | 12863-12866 | VB | denotes | p52 |
T6566 | 12860-12862 | TO | denotes | to |
T6565 | 12849-12859 | JJ | denotes | proteasome |
T6564 | 12845-12848 | DT | denotes | the |
T6563 | 12842-12844 | IN | denotes | by |
T6562 | 12832-12841 | VBN | denotes | processed |
T6561 | 12829-12831 | VBZ | denotes | is |
T6560 | 12824-12828 | NN | denotes | p100 |
T6559 | 12822-12823 | , | denotes | , |
T6558 | 12815-12822 | NN | denotes | pathway |
T6557 | 12810-12814 | DT | denotes | this |
T6556 | 12807-12809 | IN | denotes | In |
T6555 | 12805-12806 | . | denotes | . |
T6554 | 12804-12805 | -RRB- | denotes | ) |
T6553 | 12803-12804 | CD | denotes | 2 |
T6552 | 12796-12802 | NNP | denotes | Figure |
T6551 | 12795-12796 | -LRB- | denotes | ( |
T6550 | 12790-12794 | NNP | denotes | RANK |
T6549 | 12786-12789 | CC | denotes | and |
T6548 | 12784-12785 | , | denotes | , |
T6547 | 12780-12784 | NNP | denotes | CD40 |
T6546 | 12778-12779 | , | denotes | , |
T6545 | 12770-12778 | NN | denotes | receptor |
T6544 | 12765-12769 | NN | denotes | BAFF |
T6543 | 12763-12764 | , | denotes | , |
T6542 | 12755-12763 | NN | denotes | receptor |
T6541 | 12753-12754 | NN | denotes | β |
T6540 | 12741-12752 | NN | denotes | lymphotoxin |
T6539 | 12737-12740 | DT | denotes | the |
T6538 | 12734-12736 | IN | denotes | by |
T6537 | 12724-12733 | VBN | denotes | activated |
T6536 | 12721-12723 | VB | denotes | be |
T6535 | 12717-12720 | MD | denotes | can |
T6534 | 12709-12716 | NN | denotes | pathway |
T6533 | 12703-12708 | NN | denotes | NF-κB |
T6532 | 12690-12702 | JJ | denotes | noncanonical |
T6531 | 12686-12689 | DT | denotes | The |
T6530 | 12684-12685 | . | denotes | . |
T6529 | 12683-12684 | -RRB- | denotes | ) |
T6528 | 12682-12683 | CD | denotes | 1 |
T6527 | 12675-12681 | NN | denotes | Figure |
T6526 | 12674-12675 | -LRB- | denotes | ( |
T6525 | 12666-12673 | NN | denotes | pathway |
T6524 | 12662-12665 | NNP | denotes | TNF |
T6523 | 12658-12661 | DT | denotes | the |
T6522 | 12655-12657 | TO | denotes | to |
T6521 | 12647-12654 | JJ | denotes | similar |
T6520 | 12640-12646 | NN | denotes | manner |
T6519 | 12615-12639 | JJ | denotes | ubiquitination-dependent |
T6518 | 12613-12614 | DT | denotes | a |
T6517 | 12610-12612 | IN | denotes | in |
T6516 | 12606-12609 | NNP | denotes | IKK |
T6515 | 12602-12605 | CC | denotes | and |
T6514 | 12597-12601 | CD | denotes | TAK1 |
T6513 | 12588-12596 | VBP | denotes | activate |
T6512 | 12583-12587 | RB | denotes | then |
T6511 | 12574-12582 | NNS | denotes | pathways |
T6510 | 12569-12573 | DT | denotes | Both |
T6509 | 12567-12568 | . | denotes | . |
T6508 | 12556-12567 | NN | denotes | interaction |
T6507 | 12549-12555 | JJ | denotes | direct |
T6506 | 12547-12548 | DT | denotes | a |
T6505 | 12543-12546 | IN | denotes | via |
T6504 | 12541-12542 | NNP | denotes | ] |
T6503 | 12539-12541 | CD | denotes | 26 |
T6502 | 12538-12539 | NNP | denotes | [ |
T6501 | 12533-12537 | NNP | denotes | RIP1 |
T6500 | 12529-12532 | CC | denotes | and |
T6499 | 12527-12528 | NNP | denotes | ] |
T6498 | 12525-12527 | CD | denotes | 25 |
T6497 | 12524-12525 | NNP | denotes | [ |
T6496 | 12518-12523 | CD | denotes | TRAF6 |
T6495 | 12509-12517 | VBZ | denotes | recruits |
T6494 | 12504-12508 | RB | denotes | also |
T6493 | 12499-12503 | NNP | denotes | TRIF |
T6492 | 12497-12498 | . | denotes | . |
T6491 | 12496-12497 | NNP | denotes | ] |
T6490 | 12494-12496 | CD | denotes | 24 |
T6489 | 12493-12494 | NNP | denotes | [ |
T6488 | 12487-12492 | CD | denotes | TRAF6 |
T6487 | 12484-12486 | IN | denotes | of |
T6486 | 12465-12483 | NN | denotes | selfubiquitination |
T6485 | 12461-12464 | CC | denotes | and |
T6484 | 12445-12460 | NN | denotes | oligomerisation |
T6483 | 12442-12444 | TO | denotes | to |
T6482 | 12434-12441 | VBG | denotes | leading |
T6481 | 12432-12433 | , | denotes | , |
T6480 | 12427-12432 | CD | denotes | TRAF6 |
T6479 | 12423-12426 | CC | denotes | and |
T6478 | 12416-12422 | NN | denotes | family |
T6477 | 12414-12415 | -RRB- | denotes | ) |
T6476 | 12410-12414 | NNP | denotes | IRAK |
T6404 | 11970-11979 | NNS | denotes | receptors |
T6403 | 11964-11969 | JJ | denotes | other |
T6402 | 11961-11963 | TO | denotes | to |
T6401 | 11955-11960 | VBP | denotes | apply |
T6400 | 11944-11954 | NNS | denotes | principles |
T6399 | 11933-11943 | JJ | denotes | signalling |
T6398 | 11925-11932 | JJ | denotes | Similar |
T6397 | 11923-11924 | . | denotes | . |
T6396 | 11922-11923 | NNP | denotes | ] |
T6395 | 11920-11922 | CD | denotes | 23 |
T6394 | 11919-11920 | NNP | denotes | [ |
T6393 | 11911-11918 | JJ | denotes | complex |
T6392 | 11906-11910 | CD | denotes | TAK1 |
T6391 | 11902-11905 | DT | denotes | the |
T6390 | 11893-11901 | VB | denotes | activate |
T6389 | 11884-11892 | RB | denotes | directly |
T6388 | 11880-11883 | MD | denotes | can |
T6387 | 11873-11879 | NNS | denotes | chains |
T6386 | 11859-11872 | NN | denotes | polyubiquitin |
T6385 | 11848-11858 | JJ | denotes | unanchored |
T6384 | 11843-11847 | IN | denotes | that |
T6383 | 11833-11842 | VBN | denotes | suggested |
T6382 | 11824-11832 | RB | denotes | recently |
T6381 | 11820-11823 | VBD | denotes | was |
T6380 | 11817-11819 | PRP | denotes | it |
T6379 | 11814-11816 | IN | denotes | as |
T6378 | 11812-11813 | , | denotes | , |
T6377 | 11805-11812 | JJ | denotes | unclear |
T6376 | 11797-11804 | VBZ | denotes | remains |
T6375 | 11790-11796 | NNS | denotes | chains |
T6374 | 11776-11789 | NN | denotes | polyubiquitin |
T6373 | 11759-11775 | JJ | denotes | protein-anchored |
T6372 | 11756-11758 | IN | denotes | of |
T6371 | 11751-11755 | NN | denotes | role |
T6370 | 11745-11750 | JJ | denotes | exact |
T6369 | 11741-11744 | DT | denotes | The |
T6368 | 11739-11740 | . | denotes | . |
T6367 | 11738-11739 | NNP | denotes | ] |
T6366 | 11736-11738 | CD | denotes | 22 |
T6365 | 11735-11736 | NNP | denotes | [ |
T6364 | 11724-11734 | NN | denotes | complexity |
T6363 | 11716-11723 | JJ | denotes | further |
T6362 | 11711-11715 | VBZ | denotes | adds |
T6361 | 11700-11710 | NN | denotes | signalling |
T6360 | 11694-11699 | JJ | denotes | NF-κB |
T6359 | 11680-11693 | JJ | denotes | TNF-activated |
T6358 | 11676-11679 | IN | denotes | for |
T6357 | 11666-11675 | JJ | denotes | essential |
T6356 | 11663-11665 | VBZ | denotes | is |
T6355 | 11659-11662 | CC | denotes | and |
T6354 | 11652-11658 | NNS | denotes | chains |
T6353 | 11638-11651 | NN | denotes | polyubiquitin |
T6352 | 11631-11637 | JJ | denotes | linear |
T6351 | 11626-11630 | IN | denotes | with |
T6350 | 11621-11625 | NNP | denotes | NEMO |
T6349 | 11612-11620 | VBZ | denotes | modifies |
T6348 | 11607-11611 | WDT | denotes | that |
T6347 | 11599-11606 | NN | denotes | complex |
T6346 | 11592-11598 | NN | denotes | enzyme |
T6345 | 11586-11591 | CD | denotes | E2/E3 |
T6344 | 11577-11585 | JJ | denotes | distinct |
T6343 | 11575-11576 | DT | denotes | a |
T6342 | 11572-11574 | IN | denotes | of |
T6341 | 11557-11571 | NN | denotes | identification |
T6340 | 11550-11556 | JJ | denotes | recent |
T6339 | 11546-11549 | DT | denotes | The |
T6338 | 11544-11545 | . | denotes | . |
T6337 | 11532-11544 | RB | denotes | respectively |
T6336 | 11530-11531 | , | denotes | , |
T6335 | 11524-11530 | NNP | denotes | TAB1/2 |
T6334 | 11520-11523 | CC | denotes | and |
T6333 | 11515-11519 | NNP | denotes | NEMO |
T6332 | 11506-11514 | NNS | denotes | proteins |
T6331 | 11488-11505 | JJ | denotes | ubiquitin-binding |
T6330 | 11484-11487 | DT | denotes | the |
T6329 | 11480-11483 | IN | denotes | via |
T6328 | 11472-11479 | JJ | denotes | complex |
T6327 | 11467-11471 | CD | denotes | TAK1 |
T6326 | 11463-11466 | CC | denotes | and |
T6325 | 11459-11462 | NNP | denotes | IKK |
T6324 | 11455-11458 | DT | denotes | the |
T6323 | 11447-11454 | VB | denotes | recruit |
T6322 | 11444-11446 | TO | denotes | to |
T6321 | 11435-11443 | NN | denotes | scaffold |
T6320 | 11433-11434 | DT | denotes | a |
T6319 | 11426-11432 | VB | denotes | create |
T6318 | 11423-11425 | TO | denotes | to |
T6317 | 11414-11422 | VBN | denotes | believed |
T6316 | 11410-11413 | VBP | denotes | are |
T6315 | 11405-11409 | NNP | denotes | RIP1 |
T6314 | 11402-11404 | IN | denotes | on |
T6313 | 11395-11401 | NNS | denotes | chains |
T6312 | 11381-11394 | NN | denotes | polyubiquitin |
T6311 | 11377-11380 | DT | denotes | The |
T6310 | 11375-11376 | . | denotes | . |
T6309 | 11368-11375 | JJ | denotes | unclear |
T6308 | 11362-11367 | RB | denotes | still |
T6307 | 11359-11361 | VBZ | denotes | is |
T6306 | 11354-11358 | DT | denotes | each |
T6305 | 11351-11353 | IN | denotes | of |
T6697 | 13624-13627 | CC | denotes | and |
T6696 | 13618-13623 | CD | denotes | TRAF2 |
T6695 | 13610-13617 | VB | denotes | attract |
T6694 | 13607-13609 | TO | denotes | to |
T6693 | 13602-13606 | RB | denotes | also |
T6692 | 13598-13601 | CC | denotes | but |
T6304 | 11346-11350 | NN | denotes | role |
T6303 | 11337-11345 | JJ | denotes | specific |
T6302 | 11333-11336 | DT | denotes | the |
T6301 | 11329-11332 | CC | denotes | but |
T6300 | 11327-11328 | , | denotes | , |
T6299 | 11313-11327 | NN | denotes | ubiquitination |
T6298 | 11308-11312 | NNP | denotes | RIP1 |
T6297 | 11304-11307 | IN | denotes | for |
T6296 | 11293-11303 | NNS | denotes | candidates |
T6295 | 11288-11292 | JJ | denotes | good |
T6294 | 11284-11287 | VBP | denotes | are |
T6293 | 11276-11283 | NNP | denotes | cIAP1/2 |
T6292 | 11272-11275 | CC | denotes | and |
T6291 | 11264-11271 | CD | denotes | TRAF2/5 |
T6290 | 11262-11263 | . | denotes | . |
T6289 | 11256-11262 | NNS | denotes | chains |
T6288 | 11242-11255 | NN | denotes | polyubiquitin |
T6287 | 11231-11241 | JJ | denotes | K63-linked |
T6286 | 11228-11230 | IN | denotes | by |
T6285 | 11219-11227 | VBN | denotes | modified |
T6284 | 11211-11218 | RB | denotes | rapidly |
T6283 | 11208-11210 | VBZ | denotes | is |
T6282 | 11203-11207 | NNP | denotes | RIP1 |
T6281 | 11197-11202 | VBN | denotes | bound |
T6280 | 11184-11196 | JJ | denotes | TNF-receptor |
T6279 | 11182-11183 | , | denotes | , |
T6278 | 11171-11182 | NN | denotes | stimulation |
T6277 | 11167-11170 | NNP | denotes | TNF |
T6276 | 11164-11166 | IN | denotes | On |
T6275 | 11162-11163 | . | denotes | . |
T6274 | 11161-11162 | -RRB- | denotes | ) |
T6273 | 11160-11161 | CD | denotes | 1 |
T6272 | 11153-11159 | NNP | denotes | Figure |
T6271 | 11152-11153 | -LRB- | denotes | ( |
T6270 | 11146-11151 | NNP | denotes | cIAP2 |
T6269 | 11142-11145 | CC | denotes | and |
T6268 | 11140-11141 | CD | denotes | 1 |
T6267 | 11138-11139 | -RRB- | denotes | ) |
T6266 | 11134-11138 | NNP | denotes | cIAP |
T6265 | 11133-11134 | -LRB- | denotes | ( |
T6264 | 11123-11132 | NN | denotes | apoptosis |
T6263 | 11120-11122 | IN | denotes | of |
T6262 | 11110-11119 | NN | denotes | inhibitor |
T6261 | 11101-11109 | JJ | denotes | cellular |
T6260 | 11093-11100 | VBZ | denotes | ligases |
T6259 | 11083-11092 | NN | denotes | ubiquitin |
T6258 | 11080-11082 | CD | denotes | E3 |
T6257 | 11076-11079 | DT | denotes | the |
T6256 | 11071-11075 | NN | denotes | bind |
T6255 | 11066-11070 | NN | denotes | turn |
T6254 | 11063-11065 | IN | denotes | in |
T6253 | 11057-11062 | WDT | denotes | which |
T6252 | 11055-11056 | , | denotes | , |
T6251 | 11050-11055 | CD | denotes | TRAF5 |
T6250 | 11046-11049 | CC | denotes | and |
T6249 | 11044-11045 | CD | denotes | 2 |
T6248 | 11042-11043 | -RRB- | denotes | ) |
T6247 | 11038-11042 | NNP | denotes | TRAF |
T6246 | 11037-11038 | -LRB- | denotes | ( |
T6245 | 11030-11036 | NN | denotes | factor |
T6244 | 11010-11029 | JJ | denotes | receptor-associated |
T6243 | 11006-11009 | NNP | denotes | TNF |
T6242 | 10998-11005 | VBZ | denotes | ligases |
T6241 | 10988-10997 | NN | denotes | ubiquitin |
T6240 | 10985-10987 | CD | denotes | E3 |
T6239 | 10981-10984 | DT | denotes | the |
T6238 | 10977-10980 | IN | denotes | for |
T6237 | 10968-10976 | NNS | denotes | proteins |
T6236 | 10960-10967 | NN | denotes | adaptor |
T6235 | 10957-10959 | IN | denotes | as |
T6234 | 10948-10956 | VBP | denotes | function |
T6233 | 10942-10947 | WDT | denotes | which |
T6232 | 10940-10941 | , | denotes | , |
T6231 | 10939-10940 | -RRB- | denotes | ) |
T6230 | 10935-10939 | NN | denotes | RIP1 |
T6229 | 10934-10935 | -LRB- | denotes | ( |
T6228 | 10932-10933 | CD | denotes | 1 |
T6227 | 10924-10931 | NN | denotes | protein |
T6226 | 10912-10923 | VBG | denotes | interacting |
T6225 | 10903-10911 | NN | denotes | receptor |
T6224 | 10900-10902 | IN | denotes | of |
T6223 | 10896-10899 | CC | denotes | and |
T6222 | 10888-10895 | NN | denotes | protein |
T6221 | 10886-10887 | -RRB- | denotes | ) |
T6220 | 10881-10886 | NNP | denotes | TRADD |
T6219 | 10880-10881 | -LRB- | denotes | ( |
T6218 | 10873-10879 | NN | denotes | domain |
T6217 | 10867-10872 | NN | denotes | death |
T6216 | 10845-10866 | JJ | denotes | receptor-1-associated |
T6215 | 10841-10844 | NNP | denotes | TNF |
T6214 | 10838-10840 | IN | denotes | of |
T6213 | 10826-10837 | NN | denotes | recruitment |
T6212 | 10822-10825 | DT | denotes | the |
T6211 | 10819-10821 | IN | denotes | in |
T6210 | 10811-10818 | NNS | denotes | results |
T6209 | 10799-10810 | NN | denotes | stimulation |
T6208 | 10795-10798 | NNP | denotes | TNF |
T6207 | 10793-10794 | . | denotes | . |
T6206 | 10786-10793 | NN | denotes | pathway |
T6205 | 10782-10785 | NNP | denotes | TNF |
T6204 | 10778-10781 | DT | denotes | the |
T6203 | 10775-10777 | VBZ | denotes | is |
T6202 | 10766-10774 | NNS | denotes | pathways |
T6201 | 10755-10765 | VBG | denotes | signalling |
T6200 | 10749-10754 | NNP | denotes | NF-κB |
T6199 | 10741-10748 | VBN | denotes | studied |
T6198 | 10736-10740 | JJS | denotes | best |
T6197 | 10732-10735 | DT | denotes | the |
T6196 | 10729-10731 | IN | denotes | of |
T6195 | 10725-10728 | CD | denotes | One |
T6194 | 8528-8529 | . | denotes | . |
T6193 | 8527-8528 | NNP | denotes | ] |
T6192 | 8525-8527 | CD | denotes | 21 |
T6191 | 8524-8525 | NNP | denotes | [ |
T6190 | 8513-8523 | NN | denotes | activation |
T6189 | 8507-8512 | NN | denotes | NF-κB |
T5971 | 7303-7304 | -RRB- | denotes | ) |
T5970 | 7297-7303 | NN | denotes | NF-κB1 |
T5969 | 7294-7296 | IN | denotes | as |
T5968 | 7288-7293 | VBN | denotes | known |
T5967 | 7283-7287 | RB | denotes | also |
T5966 | 7282-7283 | -LRB- | denotes | ( |
T5965 | 7277-7281 | NNS | denotes | p105 |
T5964 | 7275-7276 | , | denotes | , |
T5963 | 7271-7275 | NNP | denotes | IκBε |
T5962 | 7269-7270 | , | denotes | , |
T5961 | 7265-7269 | NNP | denotes | IκBβ |
T5960 | 7263-7264 | , | denotes | , |
T5959 | 7259-7263 | NNP | denotes | IκBα |
T5958 | 7258-7259 | -LRB- | denotes | ( |
T5957 | 7253-7257 | NNS | denotes | IκBs |
T5956 | 7250-7252 | IN | denotes | of |
T5955 | 7241-7249 | NN | denotes | majority |
T5954 | 7237-7240 | DT | denotes | the |
T5953 | 7229-7236 | IN | denotes | Whereas |
T5952 | 7227-7228 | . | denotes | . |
T5951 | 7226-7227 | NNP | denotes | ] |
T5950 | 7224-7226 | CD | denotes | 19 |
T5949 | 7223-7224 | NNP | denotes | [ |
T5948 | 7215-7222 | JJ | denotes | binding |
T5947 | 7211-7214 | NN | denotes | DNA |
T5946 | 7207-7210 | CC | denotes | and |
T5945 | 7193-7206 | NN | denotes | translocation |
T5944 | 7185-7192 | JJ | denotes | nuclear |
T5943 | 7179-7184 | JJ | denotes | NF-κB |
T5942 | 7171-7178 | VBP | denotes | prevent |
T5941 | 7165-7170 | WDT | denotes | which |
T5940 | 7163-7164 | , | denotes | , |
T5939 | 7155-7163 | NNS | denotes | proteins |
T5938 | 7153-7154 | -RRB- | denotes | ) |
T5937 | 7150-7153 | NNP | denotes | IκB |
T5936 | 7149-7150 | -LRB- | denotes | ( |
T5935 | 7143-7148 | NNP | denotes | NF-κB |
T5934 | 7140-7142 | IN | denotes | of |
T5933 | 7130-7139 | NN | denotes | inhibitor |
T5932 | 7127-7129 | IN | denotes | as |
T5931 | 7124-7126 | TO | denotes | to |
T5930 | 7115-7123 | VBD | denotes | referred |
T5929 | 7106-7114 | NNS | denotes | proteins |
T5928 | 7095-7105 | JJ | denotes | inhibitory |
T5927 | 7092-7094 | IN | denotes | by |
T5926 | 7082-7091 | NNS | denotes | complexes |
T5925 | 7075-7081 | NN | denotes | latent |
T5924 | 7072-7074 | IN | denotes | as |
T5923 | 7062-7071 | NN | denotes | cytoplasm |
T5922 | 7058-7061 | DT | denotes | the |
T5921 | 7055-7057 | IN | denotes | in |
T5920 | 7043-7054 | VBN | denotes | sequestered |
T5919 | 7039-7042 | VBP | denotes | are |
T5918 | 7030-7038 | NNS | denotes | proteins |
T5917 | 7024-7029 | NN | denotes | NF-κB |
T6475 | 12409-12410 | -LRB- | denotes | ( |
T6474 | 12402-12408 | NN | denotes | kinase |
T6473 | 12385-12401 | JJ | denotes | IL-1R-associated |
T6472 | 12381-12384 | DT | denotes | the |
T6471 | 12378-12380 | IN | denotes | of |
T6470 | 12370-12377 | NNS | denotes | members |
T6469 | 12361-12369 | NNS | denotes | recruits |
T6468 | 12356-12360 | NN | denotes | turn |
T6467 | 12353-12355 | IN | denotes | in |
T6466 | 12347-12352 | CD | denotes | MyD88 |
T6465 | 12345-12346 | . | denotes | . |
T6464 | 12333-12345 | RB | denotes | respectively |
T6463 | 12331-12332 | , | denotes | , |
T6462 | 12330-12331 | -RRB- | denotes | ) |
T6461 | 12326-12330 | NNP | denotes | TRIF |
T6460 | 12325-12326 | -LRB- | denotes | ( |
T6459 | 12320-12324 | NNP | denotes | IFNβ |
T6458 | 12303-12319 | JJ | denotes | adaptor-inducing |
T6457 | 12285-12302 | JJ | denotes | domain-containing |
T6456 | 12281-12284 | NNP | denotes | TIR |
T6455 | 12277-12280 | CC | denotes | and |
T6454 | 12275-12276 | -RRB- | denotes | ) |
T6453 | 12270-12275 | NNP | denotes | MyD88 |
T6452 | 12269-12270 | -LRB- | denotes | ( |
T6451 | 12266-12268 | CD | denotes | 88 |
T6450 | 12261-12265 | NN | denotes | gene |
T6449 | 12252-12260 | NN | denotes | response |
T6448 | 12244-12251 | JJ | denotes | primary |
T6447 | 12228-12243 | NN | denotes | differentiation |
T6446 | 12220-12227 | JJ | denotes | myeloid |
T6445 | 12212-12219 | VB | denotes | recruit |
T6444 | 12209-12211 | TO | denotes | to |
T6443 | 12201-12208 | NNS | denotes | factors |
T6442 | 12192-12200 | VBG | denotes | bridging |
T6441 | 12189-12191 | IN | denotes | as |
T6440 | 12183-12188 | VBP | denotes | serve |
T6439 | 12174-12182 | RB | denotes | probably |
T6438 | 12169-12173 | RBS | denotes | most |
T6437 | 12163-12168 | WDT | denotes | which |
T6436 | 12161-12162 | , | denotes | , |
T6435 | 12160-12161 | -RRB- | denotes | ) |
T6434 | 12156-12160 | NNP | denotes | TRAM |
T6433 | 12155-12156 | -LRB- | denotes | ( |
T6432 | 12146-12154 | NN | denotes | molecule |
T6431 | 12138-12145 | NN | denotes | adaptor |
T6430 | 12125-12137 | JJ | denotes | TRIF-related |
T6429 | 12121-12124 | CC | denotes | and |
T6428 | 12119-12120 | -RRB- | denotes | ) |
T6427 | 12116-12119 | NNP | denotes | Mal |
T6426 | 12113-12115 | IN | denotes | as |
T6425 | 12110-12112 | TO | denotes | to |
T6424 | 12101-12109 | VBD | denotes | referred |
T6423 | 12096-12100 | RB | denotes | also |
T6422 | 12095-12096 | -LRB- | denotes | ( |
T6421 | 12087-12094 | NN | denotes | protein |
T6420 | 12079-12086 | NN | denotes | adaptor |
T6419 | 12070-12078 | NN | denotes | receptor |
T6418 | 12067-12069 | CD | denotes | -1 |
T6417 | 12060-12067 | NNP | denotes | Toll/IL |
T6416 | 12057-12059 | IN | denotes | of |
T6415 | 12045-12056 | NN | denotes | recruitment |
T6414 | 12041-12044 | DT | denotes | the |
T6413 | 12033-12040 | VBZ | denotes | induces |
T6412 | 12014-12032 | NN | denotes | lipopolysaccharide |
T6411 | 12011-12013 | IN | denotes | by |
T6410 | 11999-12010 | NN | denotes | stimulation |
T6409 | 11994-11998 | CD | denotes | TLR4 |
T6408 | 11992-11993 | , | denotes | , |
T6407 | 11985-11992 | NN | denotes | example |
T6406 | 11981-11984 | IN | denotes | For |
T6405 | 11979-11980 | . | denotes | . |
T6161 | 8378-8379 | : | denotes | - |
T6160 | 8373-8377 | SYM | denotes | NEMO |
T6159 | 8372-8373 | -LRB- | denotes | ( |
T6158 | 8362-8371 | NN | denotes | modulator |
T6157 | 8352-8361 | JJ | denotes | essential |
T6156 | 8346-8351 | NN | denotes | NF-κB |
T6155 | 8338-8345 | NN | denotes | subunit |
T6154 | 8327-8337 | JJ | denotes | regulatory |
T6153 | 8323-8326 | DT | denotes | the |
T6152 | 8319-8322 | CC | denotes | and |
T6151 | 8317-8318 | -RRB- | denotes | ) |
T6150 | 8313-8317 | NNP | denotes | IKKβ |
T6149 | 8309-8312 | CC | denotes | and |
T6148 | 8304-8308 | NNP | denotes | IKKα |
T6147 | 8301-8303 | IN | denotes | as |
T6146 | 8295-8300 | VBN | denotes | known |
T6145 | 8290-8294 | RB | denotes | also |
T6144 | 8289-8290 | -LRB- | denotes | ( |
T6143 | 8284-8288 | NNP | denotes | IKK2 |
T6142 | 8280-8283 | CC | denotes | and |
T6141 | 8275-8279 | NNP | denotes | IKK1 |
T6140 | 8266-8274 | NNS | denotes | subunits |
T6139 | 8256-8265 | JJ | denotes | catalytic |
T6138 | 8252-8255 | CD | denotes | two |
T6137 | 8248-8251 | DT | denotes | the |
T6136 | 8245-8247 | IN | denotes | of |
T6135 | 8235-8244 | VBN | denotes | comprised |
T6134 | 8232-8234 | VBZ | denotes | is |
T6133 | 8224-8231 | NN | denotes | complex |
T6132 | 8220-8223 | NNP | denotes | IKK |
T6131 | 8216-8219 | DT | denotes | The |
T6130 | 8214-8215 | . | denotes | . |
T6129 | 8213-8214 | NNP | denotes | ] |
T6128 | 8211-8213 | CD | denotes | 20 |
T6127 | 8210-8211 | NNP | denotes | [ |
T6126 | 8199-8209 | JJ | denotes | proteasome |
T6125 | 8195-8198 | DT | denotes | the |
T6124 | 8192-8194 | IN | denotes | by |
T6123 | 8180-8191 | NN | denotes | degradation |
T6122 | 8176-8179 | CC | denotes | and |
T6121 | 8153-8175 | NN | denotes | K48-polyubiquitination |
T6120 | 8149-8152 | PRP$ | denotes | its |
T6119 | 8146-8148 | TO | denotes | to |
T6118 | 8138-8145 | VBG | denotes | leading |
T6117 | 8130-8137 | NN | denotes | protein |
T6116 | 8126-8129 | NNP | denotes | IκB |
T6115 | 8115-8125 | JJ | denotes | inhibitory |
T6114 | 8111-8114 | DT | denotes | the |
T6113 | 8108-8110 | IN | denotes | of |
T6112 | 8092-8107 | NN | denotes | phosphorylation |
T6111 | 8083-8091 | VBZ | denotes | mediates |
T6110 | 8077-8082 | WDT | denotes | which |
T6109 | 8075-8076 | , | denotes | , |
T6108 | 8068-8075 | JJ | denotes | complex |
T6107 | 8066-8067 | -RRB- | denotes | ) |
T6106 | 8063-8066 | NNP | denotes | IKK |
T6105 | 8062-8063 | -LRB- | denotes | ( |
T6104 | 8055-8061 | NN | denotes | kinase |
T6103 | 8051-8054 | NNP | denotes | IκB |
T6102 | 8047-8050 | DT | denotes | the |
T6101 | 8044-8046 | IN | denotes | of |
T6100 | 8033-8043 | NN | denotes | activation |
T6099 | 8029-8032 | DT | denotes | the |
T6098 | 8026-8028 | IN | denotes | in |
T6097 | 8017-8025 | NN | denotes | converge |
T6096 | 8006-8016 | RB | denotes | ultimately |
T6095 | 8002-8005 | CC | denotes | but |
T6094 | 8000-8001 | , | denotes | , |
T6093 | 7992-8000 | JJ | denotes | specific |
T6092 | 7983-7991 | NN | denotes | receptor |
T6091 | 7977-7982 | RB | denotes | often |
T6090 | 7973-7976 | VBP | denotes | are |
T6089 | 7968-7972 | WDT | denotes | that |
T6088 | 7955-7967 | NNS | denotes | interactions |
T6087 | 7939-7954 | NN | denotes | protein-protein |
T6086 | 7930-7938 | JJ | denotes | proximal |
T6085 | 7927-7929 | IN | denotes | of |
T6084 | 7917-7926 | NN | denotes | formation |
T6083 | 7913-7916 | DT | denotes | the |
T6082 | 7904-7912 | VBZ | denotes | requires |
T6081 | 7894-7903 | NNS | denotes | receptors |
T6080 | 7884-7893 | JJ | denotes | different |
T6079 | 7881-7883 | IN | denotes | by |
T6078 | 7871-7880 | VBN | denotes | initiated |
T6077 | 7860-7870 | JJ | denotes | signalling |
T6076 | 7854-7859 | JJ | denotes | NF-κB |
T6075 | 7852-7853 | . | denotes | . |
T6074 | 7845-7852 | NNS | denotes | ligands |
T6073 | 7841-7844 | NNP | denotes | TLR |
T6072 | 7837-7840 | CC | denotes | and |
T6071 | 7835-7836 | , | denotes | , |
T6070 | 7830-7835 | NNP | denotes | RANKL |
T6069 | 7828-7829 | , | denotes | , |
T6068 | 7820-7828 | NNS | denotes | antigens |
T6067 | 7818-7819 | , | denotes | , |
T6066 | 7817-7818 | -RRB- | denotes | ) |
T6065 | 7813-7817 | NNP | denotes | IL-1 |
T6064 | 7811-7812 | , | denotes | , |
T6063 | 7808-7811 | NNP | denotes | TNF |
T6062 | 7806-7807 | , | denotes | , |
T6061 | 7799-7806 | NN | denotes | example |
T6060 | 7795-7798 | IN | denotes | for |
T6059 | 7794-7795 | -LRB- | denotes | ( |
T6058 | 7784-7793 | NNS | denotes | cytokines |
T6057 | 7768-7783 | JJ | denotes | proinflammatory |
T6056 | 7758-7767 | VBG | denotes | including |
T6055 | 7750-7757 | NNS | denotes | stimuli |
T6054 | 7745-7749 | JJ | denotes | many |
T6053 | 7742-7744 | IN | denotes | by |
T6052 | 7732-7741 | VBN | denotes | triggered |
T6051 | 7729-7731 | VBZ | denotes | is |
T6050 | 7725-7728 | CC | denotes | and |
T6049 | 7723-7724 | , | denotes | , |
T6048 | 7715-7723 | NN | denotes | immunity |
T6047 | 7706-7714 | JJ | denotes | adaptive |
T6046 | 7702-7705 | CC | denotes | and |
T6045 | 7695-7701 | NN | denotes | innate |
T6044 | 7692-7694 | IN | denotes | in |
T6043 | 7687-7691 | NN | denotes | role |
T6042 | 7681-7686 | JJ | denotes | major |
T6041 | 7679-7680 | DT | denotes | a |
T6040 | 7673-7678 | VBZ | denotes | plays |
T6039 | 7665-7672 | NN | denotes | pathway |
T6038 | 7659-7664 | NN | denotes | NF-κB |
T6037 | 7649-7658 | JJ | denotes | canonical |
T6036 | 7645-7648 | DT | denotes | The |
T6035 | 7643-7644 | . | denotes | . |
T6034 | 7635-7643 | NNS | denotes | pathways |
T6033 | 7629-7634 | NN | denotes | NF-κB |
T6032 | 7627-7628 | -RRB- | denotes | ) |
T6031 | 7616-7627 | NN | denotes | alternative |
T6030 | 7613-7615 | CC | denotes | or |
T6029 | 7612-7613 | -LRB- | denotes | ( |
T6028 | 7599-7611 | JJ | denotes | noncanonical |
T6027 | 7595-7598 | CC | denotes | and |
T6026 | 7593-7594 | -RRB- | denotes | ) |
T6025 | 7584-7593 | JJ | denotes | classical |
T6024 | 7581-7583 | CC | denotes | or |
T6023 | 7580-7581 | -LRB- | denotes | ( |
T6022 | 7570-7579 | JJ | denotes | canonical |
T6021 | 7563-7569 | VBD | denotes | termed |
T6020 | 7561-7562 | , | denotes | , |
T6019 | 7553-7561 | NNS | denotes | pathways |
T6018 | 7542-7552 | VBG | denotes | signalling |
T6017 | 7536-7541 | NN | denotes | NF-κB |
T6016 | 7529-7535 | JJ | denotes | unique |
T6015 | 7525-7528 | CD | denotes | two |
T6014 | 7521-7524 | VBP | denotes | are |
T6013 | 7515-7520 | EX | denotes | There |
T6012 | 7513-7514 | . | denotes | . |
T6011 | 7501-7513 | RB | denotes | respectively |
T6010 | 7499-7500 | , | denotes | , |
T6009 | 7491-7499 | NNS | denotes | subunits |
T6008 | 7485-7490 | JJ | denotes | NF-κB |
T6007 | 7481-7484 | CD | denotes | p50 |
T6006 | 7477-7480 | CC | denotes | and |
T6005 | 7473-7476 | CD | denotes | p52 |
T6004 | 7469-7472 | DT | denotes | the |
T6003 | 7466-7468 | IN | denotes | of |
T6002 | 7455-7465 | NNS | denotes | precursors |
T6001 | 7451-7454 | VBP | denotes | are |
T6000 | 7446-7450 | NNS | denotes | p105 |
T5999 | 7442-7445 | CC | denotes | and |
T5998 | 7437-7441 | NN | denotes | p100 |
T5997 | 7435-7436 | . | denotes | . |
T5996 | 7428-7435 | NN | denotes | nucleus |
T5995 | 7424-7427 | DT | denotes | the |
T5994 | 7421-7423 | IN | denotes | in |
T5993 | 7405-7420 | NN | denotes | transactivation |
T5992 | 7399-7404 | NN | denotes | NF-κB |
T5991 | 7388-7398 | JJ | denotes | potentiate |
T5990 | 7380-7387 | RB | denotes | instead |
T5989 | 7374-7379 | JJ | denotes | Bcl-3 |
T5988 | 7370-7373 | CC | denotes | and |
T5987 | 7365-7369 | NNP | denotes | IκBξ |
T5986 | 7363-7364 | , | denotes | , |
T5985 | 7358-7363 | NNP | denotes | NF-κB |
T5984 | 7355-7357 | IN | denotes | of |
T5983 | 7344-7354 | NNS | denotes | inhibitors |
T5982 | 7341-7343 | IN | denotes | as |
T5981 | 7335-7340 | VBP | denotes | serve |
T5980 | 7333-7334 | -RRB- | denotes | ) |
T5979 | 7332-7333 | -RRB- | denotes | ) |
T5978 | 7326-7332 | NN | denotes | NF-κB2 |
T5977 | 7323-7325 | IN | denotes | as |
T5976 | 7317-7322 | VBN | denotes | known |
T5975 | 7312-7316 | RB | denotes | also |
T5974 | 7311-7312 | -LRB- | denotes | ( |
T5973 | 7306-7310 | NN | denotes | p100 |
T5972 | 7304-7305 | , | denotes | , |
T6188 | 8497-8506 | JJ | denotes | canonical |
T6187 | 8493-8496 | IN | denotes | for |
T6186 | 8484-8492 | VBN | denotes | required |
T6185 | 8480-8483 | VBP | denotes | are |
T6184 | 8478-8479 | , | denotes | , |
T6183 | 8474-8478 | NNP | denotes | IKK1 |
T6182 | 8470-8473 | RB | denotes | not |
T6181 | 8466-8469 | CC | denotes | but |
T6180 | 8464-8465 | , | denotes | , |
T6179 | 8460-8464 | NNP | denotes | NEMO |
T6178 | 8456-8459 | CC | denotes | and |
T6177 | 8451-8455 | NNP | denotes | IKK2 |
T6176 | 8446-8450 | IN | denotes | that |
T6175 | 8439-8445 | VBD | denotes | showed |
T6174 | 8427-8438 | NNS | denotes | experiments |
T6173 | 8417-8426 | VBG | denotes | targeting |
T6172 | 8412-8416 | NNP | denotes | Gene |
T6171 | 8410-8411 | . | denotes | . |
T6170 | 8409-8410 | -RRB- | denotes | ) |
T6169 | 8408-8409 | CD | denotes | 1 |
T6168 | 8401-8407 | NN | denotes | Figure |
T6167 | 8400-8401 | -LRB- | denotes | ( |
T6166 | 8398-8399 | -RRB- | denotes | ) |
T6165 | 8394-8398 | NNP | denotes | IKKγ |
T6164 | 8391-8393 | IN | denotes | as |
T6163 | 8385-8390 | VBN | denotes | known |
T6162 | 8380-8384 | RB | denotes | also |
T3270 | 6984-6985 | . | denotes | . |
T3269 | 6982-6984 | NNP | denotes | RA |
T3268 | 6979-6981 | IN | denotes | in |
T3267 | 6968-6978 | NN | denotes | expression |
T3266 | 6963-6967 | NN | denotes | gene |
T3265 | 6950-6962 | JJ | denotes | inflammatory |
T3264 | 6946-6949 | CC | denotes | and |
T3263 | 6935-6945 | NN | denotes | activation |
T3262 | 6929-6934 | JJ | denotes | NF-κB |
T3261 | 6926-6928 | TO | denotes | to |
T3260 | 6915-6925 | VB | denotes | contribute |
T3259 | 6911-6914 | MD | denotes | may |
T3258 | 6904-6910 | NN | denotes | tissue |
T3257 | 6898-6903 | JJ | denotes | joint |
T3256 | 6889-6897 | JJ | denotes | inflamed |
T3255 | 6885-6888 | DT | denotes | the |
T3254 | 6882-6884 | IN | denotes | in |
T3253 | 6874-6881 | NNS | denotes | ligands |
T3252 | 6870-6873 | NNP | denotes | TLR |
T3251 | 6862-6869 | JJ | denotes | several |
T3250 | 6857-6861 | IN | denotes | that |
T3249 | 6849-6856 | VBP | denotes | suggest |
T3248 | 6841-6848 | NNS | denotes | studies |
T3247 | 6835-6840 | DT | denotes | these |
T3246 | 6833-6834 | , | denotes | , |
T3245 | 6825-6833 | RB | denotes | Together |
T3244 | 6823-6824 | . | denotes | . |
T3243 | 6822-6823 | -RRB- | denotes | ) |
T3242 | 6821-6822 | NNP | denotes | ] |
T3241 | 6816-6821 | CD | denotes | 14,15 |
T3240 | 6815-6816 | NNP | denotes | [ |
T3239 | 6812-6814 | IN | denotes | in |
T3238 | 6803-6811 | VBN | denotes | reviewed |
T3237 | 6802-6803 | -LRB- | denotes | ( |
T3236 | 6792-6801 | NNS | denotes | fragments |
T3235 | 6787-6791 | NN | denotes | acid |
T3234 | 6775-6786 | JJ | denotes | hyal-uronic |
T3233 | 6771-6774 | CC | denotes | and |
T3232 | 6769-6770 | , | denotes | , |
T3231 | 6768-6769 | NNP | denotes | C |
T3230 | 6759-6767 | NN | denotes | tenascin |
T3229 | 6757-6758 | , | denotes | , |
T3228 | 6749-6757 | NN | denotes | biglycan |
T3227 | 6747-6748 | , | denotes | , |
T3226 | 6736-6747 | NN | denotes | fibronectin |
T3225 | 6734-6735 | , | denotes | , |
T3224 | 6724-6734 | NN | denotes | fibrinogen |
T3223 | 6721-6723 | IN | denotes | as |
T3222 | 6716-6720 | JJ | denotes | such |
T3221 | 6705-6715 | NNS | denotes | components |
T3220 | 6698-6704 | NN | denotes | matrix |
T3219 | 6684-6697 | JJ | denotes | extracellular |
T3218 | 6680-6683 | VBP | denotes | are |
T3217 | 6670-6679 | NN | denotes | pathology |
T3216 | 6667-6669 | NNP | denotes | RA |
T3215 | 6664-6666 | IN | denotes | in |
T3214 | 6655-6663 | VBN | denotes | involved |
T3213 | 6652-6654 | VB | denotes | be |
T3212 | 6648-6651 | MD | denotes | may |
T3211 | 6643-6647 | WDT | denotes | that |
T3210 | 6635-6642 | NNS | denotes | ligands |
T3209 | 6631-6634 | NNP | denotes | TLR |
T3208 | 6620-6630 | JJ | denotes | endogenous |
T3207 | 6614-6619 | JJ | denotes | Other |
T3206 | 6612-6613 | . | denotes | . |
T3205 | 6611-6612 | NNP | denotes | ] |
T3204 | 6606-6611 | CD | denotes | 17,18 |
T3203 | 6605-6606 | NNP | denotes | [ |
T3202 | 6602-6604 | NNP | denotes | RA |
T3201 | 6599-6601 | IN | denotes | in |
T3200 | 6586-6598 | NN | denotes | inflammation |
T3199 | 6578-6585 | NN | denotes | chronic |
T3198 | 6565-6577 | JJ | denotes | TLR4-induced |
T3197 | 6562-6564 | IN | denotes | in |
T3196 | 6553-6561 | VBN | denotes | involved |
T3195 | 6550-6552 | VB | denotes | be |
T3194 | 6547-6549 | TO | denotes | to |
T3193 | 6537-6546 | VBN | denotes | suggested |
T3192 | 6532-6536 | VBN | denotes | been |
T3191 | 6527-6531 | VBP | denotes | have |
T3190 | 6523-6526 | CC | denotes | and |
T3189 | 6521-6522 | , | denotes | , |
T3188 | 6516-6521 | NN | denotes | fluid |
T3187 | 6507-6515 | JJ | denotes | synovial |
T3186 | 6504-6506 | NNP | denotes | RA |
T3185 | 6501-6503 | IN | denotes | in |
T3184 | 6493-6500 | JJ | denotes | present |
T3183 | 6482-6492 | RB | denotes | abundantly |
T3182 | 6477-6481 | RB | denotes | also |
T3181 | 6473-6476 | VBP | denotes | are |
T3180 | 6471-6472 | , | denotes | , |
T3179 | 6463-6471 | NNS | denotes | proteins |
T3178 | 6447-6462 | JJ | denotes | calcium-binding |
T3177 | 6444-6446 | IN | denotes | of |
T3176 | 6437-6443 | NN | denotes | family |
T3175 | 6432-6436 | NNP | denotes | S100 |
T3174 | 6428-6431 | DT | denotes | the |
T3173 | 6425-6427 | TO | denotes | to |
T3172 | 6415-6424 | VBG | denotes | belonging |
T3171 | 6405-6414 | NNS | denotes | molecules |
T3170 | 6397-6404 | NN | denotes | pattern |
T3169 | 6387-6396 | JJ | denotes | molecular |
T3168 | 6369-6386 | JJ | denotes | damage-associated |
T3167 | 6367-6368 | , | denotes | , |
T3166 | 6365-6367 | CD | denotes | 14 |
T3165 | 6357-6364 | NN | denotes | protein |
T3164 | 6341-6356 | JJ | denotes | myeloid-related |
T3163 | 6337-6340 | CC | denotes | and |
T3162 | 6335-6336 | CD | denotes | 8 |
T3161 | 6327-6334 | NN | denotes | protein |
T3160 | 6311-6326 | JJ | denotes | Myeloid-related |
T3159 | 6309-6310 | . | denotes | . |
T3158 | 6308-6309 | NNP | denotes | ] |
T3157 | 6306-6308 | CD | denotes | 16 |
T3156 | 6305-6306 | NNP | denotes | [ |
T3155 | 6300-6304 | NNS | denotes | mice |
T3154 | 6297-6299 | IN | denotes | in |
T3153 | 6287-6296 | NNS | denotes | arthritis |
T3152 | 6270-6286 | JJ | denotes | collagen-induced |
T3151 | 6262-6269 | IN | denotes | against |
T3150 | 6254-6261 | VBP | denotes | protect |
T3149 | 6248-6253 | NNP | denotes | HMGB1 |
T3148 | 6245-6247 | IN | denotes | of |
T3147 | 6238-6244 | NN | denotes | domain |
T3146 | 6233-6237 | NNP | denotes | BoxA |
T3145 | 6220-6232 | JJ | denotes | antagonistic |
T3144 | 6216-6219 | DT | denotes | the |
T3143 | 6213-6215 | CC | denotes | or |
T3142 | 6202-6212 | NNS | denotes | antibodies |
T3141 | 6189-6201 | VBG | denotes | neutralising |
T3140 | 6183-6188 | NNP | denotes | HMGB1 |
T3139 | 6179-6182 | CC | denotes | and |
T3138 | 6172-6178 | NN | denotes | tissue |
T3137 | 6163-6171 | JJ | denotes | synovial |
T3136 | 6160-6162 | NNP | denotes | RA |
T3135 | 6157-6159 | IN | denotes | in |
T3134 | 6147-6156 | VBN | denotes | increased |
T3133 | 6144-6146 | VBZ | denotes | is |
T3132 | 6138-6143 | CD | denotes | HMGB1 |
T3131 | 6136-6137 | . | denotes | . |
T3130 | 6127-6136 | NN | denotes | pathology |
T3129 | 6124-6126 | NNP | denotes | RA |
T3128 | 6121-6123 | IN | denotes | in |
T3119 | 6063-6066 | CD | denotes | one |
T3118 | 6060-6062 | VBZ | denotes | is |
T3117 | 6058-6059 | , | denotes | , |
T3116 | 6053-6058 | NNS | denotes | cells |
T3115 | 6044-6052 | JJ | denotes | necrotic |
T3114 | 6041-6043 | IN | denotes | by |
T3113 | 6032-6040 | VBN | denotes | released |
T3112 | 6022-6031 | RB | denotes | passively |
T3111 | 6019-6021 | CC | denotes | or |
T3110 | 6007-6018 | NNS | denotes | macrophages |
T3109 | 6004-6006 | IN | denotes | by |
T3108 | 5995-6003 | VBN | denotes | secreted |
T3107 | 5986-5994 | RB | denotes | actively |
T3106 | 5983-5985 | VB | denotes | be |
T3105 | 5979-5982 | MD | denotes | can |
T3104 | 5974-5978 | WDT | denotes | that |
T3103 | 5964-5973 | NN | denotes | component |
T3102 | 5954-5963 | NN | denotes | chromatin |
T3101 | 5944-5953 | VBN | denotes | conserved |
T3100 | 5937-5943 | RB | denotes | highly |
T3099 | 5935-5936 | DT | denotes | a |
T3098 | 5933-5934 | , | denotes | , |
T3097 | 5932-5933 | -RRB- | denotes | ) |
T3096 | 5927-5932 | CD | denotes | HMGB1 |
T3095 | 5926-5927 | -LRB- | denotes | ( |
T3094 | 5924-5925 | CD | denotes | 1 |
T3093 | 5916-5923 | NN | denotes | protein |
T3092 | 5904-5915 | JJ | denotes | chromosomal |
T3091 | 5900-5903 | NN | denotes | box |
T3090 | 5894-5899 | NN | denotes | group |
T3089 | 5885-5893 | NN | denotes | mobility |
T3088 | 5880-5884 | NNP | denotes | High |
T3087 | 5878-5879 | . | denotes | . |
T3086 | 5871-5878 | NN | denotes | disease |
T3085 | 5867-5870 | DT | denotes | the |
T3084 | 5864-5866 | IN | denotes | of |
T3083 | 5851-5863 | NN | denotes | pathogenesis |
T3082 | 5847-5850 | DT | denotes | the |
T3081 | 5844-5846 | IN | denotes | in |
T3080 | 5834-5843 | JJ | denotes | important |
T3079 | 5828-5833 | VBG | denotes | being |
T3078 | 5825-5827 | IN | denotes | as |
T3077 | 5812-5824 | NN | denotes | inflammation |
T3076 | 5798-5811 | JJ | denotes | TLR-dependent |
T3075 | 5789-5797 | VB | denotes | identify |
T3074 | 5781-5788 | RB | denotes | clearly |
T3073 | 5770-5780 | VBG | denotes | signalling |
T3072 | 5766-5769 | NNP | denotes | TLR |
T3071 | 5760-5765 | VB | denotes | block |
T3070 | 5757-5759 | TO | denotes | to |
T3069 | 5746-5756 | NNS | denotes | strategies |
T3068 | 5743-5745 | CC | denotes | or |
T3067 | 5738-5742 | NNS | denotes | mice |
T3066 | 5729-5737 | NN | denotes | knockout |
T3065 | 5725-5728 | NNP | denotes | TLR |
T3064 | 5719-5724 | VBG | denotes | using |
T3063 | 5712-5718 | NNS | denotes | models |
T3062 | 5705-5711 | NN | denotes | animal |
T3061 | 5703-5704 | , | denotes | , |
T3060 | 5695-5703 | RB | denotes | Moreover |
T3059 | 5693-5694 | . | denotes | . |
T3058 | 5685-5693 | NNS | denotes | patients |
T3057 | 5682-5684 | NNP | denotes | RA |
T3056 | 5679-5681 | IN | denotes | of |
T3055 | 5672-5678 | NNS | denotes | joints |
T3054 | 5663-5671 | JJ | denotes | inflamed |
T3053 | 5659-5662 | DT | denotes | the |
T3052 | 5652-5658 | IN | denotes | within |
T3051 | 5644-5651 | JJ | denotes | present |
T3050 | 5640-5643 | VBP | denotes | are |
T3049 | 5632-5639 | NNS | denotes | ligands |
T3048 | 5621-5631 | JJ | denotes | endogenous |
T3047 | 5613-5620 | JJ | denotes | various |
T3046 | 5609-5612 | CC | denotes | and |
T3045 | 5601-5608 | NNS | denotes | tissues |
T3044 | 5592-5600 | JJ | denotes | synovial |
T3043 | 5589-5591 | NNP | denotes | RA |
T3042 | 5586-5588 | IN | denotes | in |
T3041 | 5576-5585 | VBN | denotes | expressed |
T3040 | 5572-5575 | VBP | denotes | are |
T3039 | 5567-5571 | NNS | denotes | TLRs |
T3038 | 5565-5566 | . | denotes | . |
T3037 | 5564-5565 | -RRB- | denotes | ) |
T3036 | 5563-5564 | NNP | denotes | ] |
T3035 | 5558-5563 | CD | denotes | 14,15 |
T3034 | 5557-5558 | NNP | denotes | [ |
T3033 | 5554-5556 | IN | denotes | in |
T3032 | 5545-5553 | VBN | denotes | reviewed |
T3031 | 5544-5545 | -LRB- | denotes | ( |
T3030 | 5531-5543 | NN | denotes | inflammation |
T3029 | 5523-5530 | JJ | denotes | sterile |
T3028 | 5513-5522 | JJ | denotes | so-called |
T3027 | 5504-5512 | VBG | denotes | inducing |
T3026 | 5499-5503 | NNS | denotes | TLRs |
T3025 | 5496-5498 | IN | denotes | of |
T3024 | 5485-5495 | NNS | denotes | activators |
T3023 | 5475-5484 | NN | denotes | candidate |
T3022 | 5472-5474 | IN | denotes | as |
T3021 | 5463-5471 | VBN | denotes | reported |
T3020 | 5458-5462 | VBN | denotes | been |
T3019 | 5453-5457 | VB | denotes | have |
T3018 | 5451-5452 | : | denotes | - |
T3017 | 5445-5450 | NNS | denotes | cells |
T3016 | 5441-5444 | CC | denotes | and |
T3015 | 5433-5440 | NNS | denotes | tissues |
T3014 | 5428-5432 | NN | denotes | host |
T3013 | 5423-5427 | IN | denotes | from |
T3012 | 5415-5422 | VBN | denotes | derived |
T3011 | 5406-5414 | NNS | denotes | proteins |
T3010 | 5403-5405 | IN | denotes | of |
T3009 | 5397-5402 | NN | denotes | group |
T3008 | 5395-5396 | DT | denotes | a |
T3007 | 5393-5394 | : | denotes | - |
T3006 | 5385-5392 | NNS | denotes | ligands |
T3005 | 5374-5384 | JJ | denotes | endogenous |
T3004 | 5371-5373 | IN | denotes | of |
T3003 | 5364-5370 | NN | denotes | number |
T3002 | 5353-5363 | VBG | denotes | increasing |
T3001 | 5350-5352 | DT | denotes | an |
T3000 | 5348-5349 | , | denotes | , |
T2999 | 5341-5348 | NNS | denotes | ligands |
T2998 | 5331-5340 | JJ | denotes | microbial |
T2997 | 5328-5330 | TO | denotes | to |
T2996 | 5319-5327 | NN | denotes | addition |
T2995 | 5316-5318 | IN | denotes | In |
T2994 | 5314-5315 | . | denotes | . |
T2993 | 5312-5314 | NNP | denotes | RA |
T2992 | 5309-5311 | IN | denotes | in |
T2991 | 5296-5308 | NN | denotes | inflammation |
T2990 | 5280-5295 | JJ | denotes | NF-κB-dependent |
T2989 | 5271-5279 | VBG | denotes | inducing |
T2988 | 5267-5270 | IN | denotes | for |
T2987 | 5256-5266 | NNS | denotes | candidates |
T2986 | 5246-5255 | JJ | denotes | potential |
T2985 | 5242-5245 | VBP | denotes | are |
T2984 | 5238-5241 | CC | denotes | and |
T2983 | 5229-5237 | NNS | denotes | diseases |
T2982 | 5218-5228 | JJ | denotes | autoimmune |
T2981 | 5215-5217 | IN | denotes | of |
T2980 | 5207-5214 | NN | denotes | variety |
T2979 | 5205-5206 | DT | denotes | a |
T2978 | 5202-5204 | IN | denotes | in |
T2977 | 5191-5201 | VBN | denotes | implicated |
T2976 | 5186-5190 | VBN | denotes | been |
T2975 | 5181-5185 | VBP | denotes | have |
T2974 | 5179-5180 | -RRB- | denotes | ) |
T2973 | 5175-5179 | NNS | denotes | TLRs |
T2972 | 5174-5175 | -LRB- | denotes | ( |
T2971 | 5164-5173 | NNS | denotes | receptors |
T2970 | 5154-5163 | JJ | denotes | Toll-like |
T2969 | 5152-5153 | . | denotes | . |
T2968 | 5151-5152 | NNP | denotes | ] |
T2967 | 5149-5151 | CD | denotes | 13 |
T2966 | 5148-5149 | NNP | denotes | [ |
T2965 | 5145-5147 | NNP | denotes | RA |
T2964 | 5135-5144 | VBG | denotes | including |
T2963 | 5122-5134 | NN | denotes | inflammation |
T2962 | 5114-5121 | JJ | denotes | chronic |
T2961 | 5111-5113 | IN | denotes | of |
T2960 | 5105-5110 | NNS | denotes | sites |
T2959 | 5102-5104 | IN | denotes | at |
T2958 | 5092-5101 | NN | denotes | formation |
T2957 | 5086-5091 | NN | denotes | organ |
T2956 | 5077-5085 | JJ | denotes | lymphoid |
T2955 | 5068-5076 | JJ | denotes | tertiary |
T2954 | 5065-5067 | IN | denotes | in |
T2953 | 5054-5064 | VBN | denotes | implicated |
T2952 | 5049-5053 | VBN | denotes | been |
T2951 | 5045-5048 | VBZ | denotes | has |
T2950 | 5034-5044 | NN | denotes | signalling |
T2949 | 5025-5033 | NN | denotes | receptor |
T2948 | 5023-5024 | NN | denotes | β |
T2947 | 5011-5022 | NN | denotes | lymphotoxin |
T2946 | 5009-5010 | , | denotes | , |
T2945 | 5002-5009 | RB | denotes | Finally |
T2944 | 5000-5001 | . | denotes | . |
T2943 | 4999-5000 | NNP | denotes | ] |
T2942 | 4997-4999 | CD | denotes | 13 |
T2941 | 4996-4997 | NNP | denotes | [ |
T2940 | 4993-4995 | NNP | denotes | RA |
T2939 | 4985-4992 | VB | denotes | counter |
T2938 | 4982-4984 | TO | denotes | to |
T2937 | 4972-4981 | VBN | denotes | developed |
T2936 | 4967-4971 | VBN | denotes | been |
T2935 | 4962-4966 | VBP | denotes | have |
T2934 | 4957-4961 | NNP | denotes | BAFF |
T2933 | 4954-4956 | IN | denotes | of |
T2932 | 4942-4953 | NNS | denotes | antagonists |
T2931 | 4938-4941 | CC | denotes | and |
T2930 | 4936-4937 | , | denotes | , |
T2929 | 4934-4936 | NNP | denotes | RA |
T2928 | 4930-4933 | IN | denotes | for |
T2927 | 4915-4929 | JJ | denotes | characteristic |
T2926 | 4910-4914 | RB | denotes | also |
T2925 | 4907-4909 | VBZ | denotes | is |
T2924 | 4905-4906 | , | denotes | , |
T2923 | 4894-4905 | NNS | denotes | lymphocytes |
T2922 | 4892-4893 | NNP | denotes | B |
T2921 | 4882-4891 | VBG | denotes | producing |
T2920 | 4880-4881 | : | denotes | - |
T2919 | 4868-4880 | NN | denotes | autoantibody |
T2918 | 4865-4867 | IN | denotes | of |
T2917 | 4856-4864 | NN | denotes | survival |
T2916 | 4852-4855 | DT | denotes | the |
T2915 | 4843-4851 | VBG | denotes | allowing |
T2914 | 4841-4842 | , | denotes | , |
T2913 | 4840-4841 | -RRB- | denotes | ) |
T2912 | 4836-4840 | NNP | denotes | BAFF |
T2911 | 4835-4836 | -LRB- | denotes | ( |
T2910 | 4828-4834 | NN | denotes | factor |
T2909 | 4817-4827 | VBG | denotes | activating |
T2908 | 4810-4816 | NNP | denotes | B-cell |
T2907 | 4803-4809 | NN | denotes | member |
T2906 | 4796-4802 | NN | denotes | family |
T2905 | 4787-4795 | NN | denotes | receptor |
T2904 | 4783-4786 | NNP | denotes | TNF |
T2892 | 4716-4726 | NNS | denotes | antibodies |
T2891 | 4705-4715 | JJ | denotes | pathogenic |
T2890 | 4701-4704 | CC | denotes | and |
T2889 | 4689-4700 | VBN | denotes | established |
T2888 | 4686-4688 | VBZ | denotes | is |
T2887 | 4678-4685 | NN | denotes | disease |
T2886 | 4673-4677 | RB | denotes | once |
T2885 | 4664-4672 | VBN | denotes | required |
T2884 | 4660-4663 | RB | denotes | not |
T2883 | 4656-4659 | VBP | denotes | are |
T2882 | 4652-4655 | CC | denotes | but |
T2881 | 4650-4651 | , | denotes | , |
T2880 | 4641-4650 | NN | denotes | induction |
T2879 | 4631-4640 | NN | denotes | arthritis |
T2878 | 4628-4630 | IN | denotes | of |
T2877 | 4621-4627 | NNS | denotes | stages |
T2876 | 4613-4620 | JJ | denotes | initial |
T2875 | 4609-4612 | DT | denotes | the |
T2874 | 4606-4608 | IN | denotes | at |
T2873 | 4596-4605 | JJ | denotes | important |
T2872 | 4593-4595 | VB | denotes | be |
T2871 | 4589-4592 | MD | denotes | may |
T2870 | 4581-4588 | NNS | denotes | signals |
T2869 | 4576-4580 | NNP | denotes | CD40 |
T2868 | 4571-4575 | WDT | denotes | that |
T2867 | 4560-4570 | NN | denotes | conclusion |
T2866 | 4556-4559 | DT | denotes | the |
T2865 | 4553-4555 | TO | denotes | to |
T2864 | 4549-4552 | VBD | denotes | led |
T2863 | 4538-4548 | NNS | denotes | antibodies |
T2862 | 4527-4537 | JJ | denotes | anti-CD154 |
T2861 | 4524-4526 | CC | denotes | or |
T2860 | 4514-4523 | JJ | denotes | anti-CD40 |
T2859 | 4501-4513 | JJ | denotes | antagonistic |
T2858 | 4496-4500 | IN | denotes | with |
T2857 | 4488-4495 | NNS | denotes | studies |
T2856 | 4486-4487 | , | denotes | , |
T2855 | 4479-4486 | RB | denotes | However |
T2854 | 4477-4478 | . | denotes | . |
T2853 | 4466-4477 | NN | denotes | destruction |
T2852 | 4460-4465 | JJ | denotes | joint |
T2851 | 4457-4459 | TO | denotes | to |
T2850 | 4445-4456 | VBZ | denotes | contributes |
T2849 | 4439-4444 | WDT | denotes | which |
T2848 | 4437-4438 | , | denotes | , |
T2847 | 4427-4437 | NNS | denotes | chemokines |
T2846 | 4423-4426 | CC | denotes | and |
T2845 | 4413-4422 | NNS | denotes | cytokines |
T2844 | 4397-4412 | JJ | denotes | proinflammatory |
T2843 | 4394-4396 | IN | denotes | of |
T2842 | 4384-4393 | NN | denotes | secretion |
T2841 | 4380-4383 | CC | denotes | and |
T2840 | 4366-4379 | NN | denotes | proliferation |
T2839 | 4355-4365 | NN | denotes | fibroblast |
T2838 | 4352-4354 | IN | denotes | in |
T2837 | 4342-4351 | VBG | denotes | resulting |
T2836 | 4331-4341 | NN | denotes | activation |
T2835 | 4325-4330 | NNP | denotes | NF-κB |
T2834 | 4316-4324 | VBZ | denotes | triggers |
T2833 | 4314-4315 | , | denotes | , |
T2832 | 4309-4314 | NNS | denotes | cells |
T2831 | 4307-4308 | NNP | denotes | T |
T2830 | 4305-4306 | CD | denotes | + |
T2829 | 4302-4305 | NNP | denotes | CD4 |
T2828 | 4292-4301 | VBN | denotes | activated |
T2827 | 4289-4291 | IN | denotes | of |
T2826 | 4281-4288 | NN | denotes | surface |
T2825 | 4277-4280 | DT | denotes | the |
T2824 | 4274-4276 | IN | denotes | on |
T2823 | 4264-4273 | VBN | denotes | expressed |
T2822 | 4252-4263 | RB | denotes | transiently |
T2821 | 4249-4251 | VBZ | denotes | is |
T2820 | 4243-4248 | WDT | denotes | which |
T2819 | 4241-4242 | , | denotes | , |
T2818 | 4240-4241 | -RRB- | denotes | ) |
T2817 | 4235-4240 | NNP | denotes | CD154 |
T2816 | 4234-4235 | -LRB- | denotes | ( |
T2815 | 4227-4233 | NN | denotes | ligand |
T2814 | 4222-4226 | NNP | denotes | CD40 |
T2813 | 4218-4221 | DT | denotes | the |
T2812 | 4215-4217 | IN | denotes | of |
T2811 | 4207-4214 | VBG | denotes | Binding |
T2810 | 4205-4206 | . | denotes | . |
T2809 | 4204-4205 | NNP | denotes | ] |
T2808 | 4202-4204 | CD | denotes | 10 |
T2807 | 4201-4202 | NNP | denotes | [ |
T2806 | 4197-4200 | NNP | denotes | TNF |
T2805 | 4187-4196 | VBG | denotes | including |
T2804 | 4177-4186 | NNS | denotes | cytokines |
T2803 | 4161-4176 | JJ | denotes | proinflammatory |
T2802 | 4158-4160 | IN | denotes | by |
T2801 | 4146-4157 | VBN | denotes | upregulated |
T2800 | 4143-4145 | VB | denotes | be |
T2799 | 4139-4142 | MD | denotes | can |
T2798 | 4135-4138 | CC | denotes | and |
T2797 | 4133-4134 | , | denotes | , |
T2796 | 4128-4133 | NNS | denotes | cells |
T2795 | 4118-4127 | JJ | denotes | dendritic |
T2794 | 4114-4117 | CC | denotes | and |
T2793 | 4112-4113 | , | denotes | , |
T3127 | 6112-6120 | VBN | denotes | involved |
T3126 | 6104-6111 | NNS | denotes | ligands |
T3125 | 6099-6103 | CD | denotes | TLR4 |
T3124 | 6088-6098 | JJ | denotes | endogenous |
T3123 | 6079-6087 | JJ | denotes | putative |
T3122 | 6074-6078 | RBS | denotes | most |
T3121 | 6070-6073 | DT | denotes | the |
T3120 | 6067-6069 | IN | denotes | of |
T2792 | 4101-4112 | NNS | denotes | macrophages |
T2791 | 4099-4100 | , | denotes | , |
T2790 | 4094-4099 | NNS | denotes | cells |
T2789 | 4092-4093 | NNP | denotes | B |
T2788 | 4090-4091 | , | denotes | , |
T2787 | 4085-4090 | NNS | denotes | cells |
T2786 | 4076-4084 | JJ | denotes | synovial |
T2785 | 4073-4075 | NNP | denotes | RA |
T2784 | 4069-4072 | CC | denotes | and |
T2783 | 4060-4068 | NNS | denotes | patients |
T2782 | 4057-4059 | NNP | denotes | RA |
T2781 | 4053-4056 | CC | denotes | and |
T2780 | 4046-4052 | JJ | denotes | normal |
T2779 | 4041-4045 | IN | denotes | from |
T2778 | 4029-4040 | NNS | denotes | fibroblasts |
T2777 | 4022-4028 | NN | denotes | muscle |
T2776 | 4015-4021 | JJ | denotes | smooth |
T2775 | 4005-4014 | VBG | denotes | including |
T2774 | 4003-4004 | , | denotes | , |
T2773 | 3998-4003 | NNS | denotes | types |
T2772 | 3993-3997 | NN | denotes | cell |
T2771 | 3990-3992 | IN | denotes | of |
T2770 | 3982-3989 | NN | denotes | variety |
T2769 | 3980-3981 | DT | denotes | a |
T2768 | 3977-3979 | IN | denotes | on |
T2767 | 3967-3976 | VBN | denotes | expressed |
T2766 | 3954-3966 | RB | denotes | functionally |
T2765 | 3951-3953 | VBZ | denotes | is |
T2764 | 3946-3950 | WDT | denotes | that |
T2763 | 3939-3945 | NN | denotes | member |
T2762 | 3932-3938 | NN | denotes | family |
T2761 | 3923-3931 | NN | denotes | receptor |
T2760 | 3919-3922 | NN | denotes | TNF |
T2759 | 3911-3918 | DT | denotes | another |
T2758 | 3908-3910 | VBZ | denotes | is |
T2757 | 3903-3907 | CD | denotes | CD40 |
T2756 | 3901-3902 | . | denotes | . |
T2755 | 3900-3901 | NNP | denotes | ] |
T2754 | 3899-3900 | CD | denotes | 7 |
T2753 | 3898-3899 | NN | denotes | [ |
T2752 | 3893-3897 | NN | denotes | loss |
T2751 | 3888-3892 | NN | denotes | bone |
T2750 | 3883-3887 | IN | denotes | with |
T2749 | 3872-3882 | VBN | denotes | associated |
T2748 | 3863-3871 | NNS | denotes | diseases |
T2747 | 3857-3862 | JJ | denotes | other |
T2746 | 3853-3856 | CC | denotes | and |
T2745 | 3843-3852 | NN | denotes | pathology |
T2744 | 3840-3842 | NNP | denotes | RA |
T2743 | 3837-3839 | IN | denotes | in |
T2742 | 3828-3836 | VBN | denotes | involved |
T2741 | 3825-3827 | VB | denotes | be |
T2740 | 3822-3824 | TO | denotes | to |
T2739 | 3815-3821 | JJ | denotes | likely |
T2738 | 3811-3814 | VBP | denotes | are |
T2737 | 3800-3810 | VBG | denotes | signalling |
T2736 | 3789-3799 | NN | denotes | RANK-NF-κB |
T2735 | 3782-3788 | JJ | denotes | proper |
T2734 | 3779-3781 | IN | denotes | in |
T2733 | 3771-3778 | NNS | denotes | defects |
T2732 | 3767-3770 | CC | denotes | and |
T2731 | 3765-3766 | , | denotes | , |
T2730 | 3747-3765 | NN | denotes | osteoclastogenesis |
T2729 | 3743-3746 | IN | denotes | for |
T2728 | 3733-3742 | JJ | denotes | important |
T2727 | 3730-3732 | VBZ | denotes | is |
T2726 | 3728-3729 | , | denotes | , |
T2725 | 3722-3728 | NN | denotes | member |
T2724 | 3715-3721 | NN | denotes | family |
T2723 | 3706-3714 | NN | denotes | receptor |
T2722 | 3702-3705 | NNP | denotes | TNF |
T2721 | 3700-3701 | DT | denotes | a |
T2720 | 3698-3699 | , | denotes | , |
T2719 | 3697-3698 | -RRB- | denotes | ) |
T2718 | 3693-3697 | NNP | denotes | RANK |
T2717 | 3692-3693 | -LRB- | denotes | ( |
T2716 | 3686-3691 | NNP | denotes | NF-κB |
T2715 | 3683-3685 | IN | denotes | of |
T2714 | 3673-3682 | NN | denotes | activator |
T2713 | 3664-3672 | NN | denotes | receptor |
T2712 | 3661-3663 | IN | denotes | by |
T2711 | 3650-3660 | NN | denotes | activation |
T2710 | 3644-3649 | JJ | denotes | NF-κB |
T2709 | 3642-3643 | . | denotes | . |
T2708 | 3641-3642 | -RRB- | denotes | ) |
T2707 | 3640-3641 | NNP | denotes | ] |
T2706 | 3639-3640 | CD | denotes | 3 |
T2705 | 3638-3639 | NNP | denotes | [ |
T2704 | 3635-3637 | IN | denotes | in |
T2703 | 3626-3634 | VBN | denotes | reviewed |
T2702 | 3625-3626 | -LRB- | denotes | ( |
T2701 | 3622-3624 | NNP | denotes | RA |
T2700 | 3619-3621 | IN | denotes | in |
T2699 | 3608-3618 | NNS | denotes | activities |
T2698 | 3591-3607 | JJ | denotes | pro-inflammatory |
T2697 | 3585-3590 | PRP$ | denotes | their |
T2696 | 3582-3584 | IN | denotes | of |
T2695 | 3577-3581 | JJS | denotes | most |
T2694 | 3568-3576 | VBZ | denotes | mediates |
T2693 | 3558-3567 | NNS | denotes | cytokines |
T2692 | 3552-3557 | DT | denotes | these |
T2691 | 3549-3551 | IN | denotes | by |
T2690 | 3538-3548 | NN | denotes | activation |
T2689 | 3532-3537 | JJ | denotes | NF-κB |
T2688 | 3527-3531 | DT | denotes | that |
T2687 | 3518-3526 | VBN | denotes | expected |
T2686 | 3515-3517 | VB | denotes | be |
T2685 | 3511-3514 | MD | denotes | can |
T2684 | 3508-3510 | PRP | denotes | it |
T2683 | 3504-3507 | CC | denotes | and |
T2682 | 3498-3503 | NN | denotes | NF-κB |
T2681 | 3495-3497 | IN | denotes | of |
T2680 | 3484-3494 | NNS | denotes | activators |
T2679 | 3477-3483 | JJ | denotes | potent |
T2678 | 3472-3476 | RB | denotes | very |
T2677 | 3467-3471 | DT | denotes | both |
T2633 | 3250-3252 | IN | denotes | in |
T2632 | 3244-3249 | NN | denotes | NF-κB |
T2631 | 3235-3243 | VBP | denotes | activate |
T2630 | 3230-3234 | IN | denotes | that |
T2629 | 3221-3229 | VBZ | denotes | triggers |
T2628 | 3211-3220 | JJ | denotes | molecular |
T2627 | 3207-3210 | DT | denotes | the |
T2626 | 3204-3206 | IN | denotes | of |
T2625 | 3189-3203 | NN | denotes | identification |
T2624 | 3185-3188 | DT | denotes | the |
T2623 | 3180-3184 | IN | denotes | with |
T2622 | 3174-3179 | NNS | denotes | deals |
T2621 | 3165-3173 | NN | denotes | research |
T2620 | 3160-3164 | JJ | denotes | much |
T2619 | 3158-3159 | , | denotes | , |
T2618 | 3156-3158 | NNP | denotes | RA |
T2617 | 3153-3155 | IN | denotes | in |
T2616 | 3140-3152 | NN | denotes | inflammation |
T2615 | 3137-3139 | IN | denotes | of |
T2614 | 3129-3136 | NN | denotes | process |
T2613 | 3125-3128 | DT | denotes | the |
T2612 | 3122-3124 | TO | denotes | to |
T2611 | 3114-3121 | JJ | denotes | central |
T2610 | 3111-3113 | VBZ | denotes | is |
T2609 | 3105-3110 | NNP | denotes | NF-κB |
T2608 | 3099-3104 | IN | denotes | Since |
T2903 | 4779-4782 | DT | denotes | the |
T2902 | 4776-4778 | IN | denotes | of |
T2901 | 4765-4775 | NN | denotes | expression |
T2900 | 4756-4764 | VBN | denotes | Enhanced |
T2899 | 4754-4755 | . | denotes | . |
T2898 | 4753-4754 | NNP | denotes | ] |
T2897 | 4748-4753 | CD | denotes | 11,12 |
T2896 | 4747-4748 | NNP | denotes | [ |
T2895 | 4739-4746 | JJ | denotes | present |
T2894 | 4731-4738 | RB | denotes | already |
T2893 | 4727-4730 | VBP | denotes | are |
T2676 | 3463-3466 | VBP | denotes | are |
T2675 | 3458-3462 | NNP | denotes | IL-1 |
T2674 | 3454-3457 | CC | denotes | and |
T2673 | 3450-3453 | NNP | denotes | TNF |
T2672 | 3448-3449 | . | denotes | . |
T2671 | 3447-3448 | -RRB- | denotes | ) |
T2670 | 3446-3447 | NNP | denotes | ] |
T2669 | 3445-3446 | CD | denotes | 9 |
T2668 | 3444-3445 | NNP | denotes | [ |
T2667 | 3441-3443 | IN | denotes | in |
T2666 | 3432-3440 | VBN | denotes | reviewed |
T2665 | 3431-3432 | -LRB- | denotes | ( |
T2664 | 3428-3430 | NNP | denotes | RA |
T2663 | 3421-3427 | JJ | denotes | severe |
T2662 | 3417-3420 | IN | denotes | for |
T2661 | 3407-3416 | NN | denotes | treatment |
T2660 | 3397-3406 | JJ | denotes | effective |
T2659 | 3394-3396 | DT | denotes | an |
T2658 | 3391-3393 | VBZ | denotes | is |
T2657 | 3379-3390 | NNS | denotes | antagonists |
T2656 | 3375-3378 | NNP | denotes | TNF |
T2655 | 3372-3374 | IN | denotes | of |
T2654 | 3357-3371 | NN | denotes | administration |
T2653 | 3353-3356 | CC | denotes | and |
T2652 | 3351-3352 | , | denotes | , |
T2651 | 3347-3351 | NN | denotes | role |
T2650 | 3337-3346 | JJ | denotes | important |
T2649 | 3334-3336 | DT | denotes | an |
T2648 | 3329-3333 | VBP | denotes | play |
T2647 | 3324-3328 | NNP | denotes | IL-1 |
T2646 | 3320-3323 | CC | denotes | and |
T2645 | 3316-3319 | NNP | denotes | TNF |
T2644 | 3313-3315 | IN | denotes | as |
T2643 | 3308-3312 | JJ | denotes | such |
T2642 | 3298-3307 | NNS | denotes | cytokines |
T2641 | 3282-3297 | JJ | denotes | proinflammatory |
T2640 | 3277-3281 | IN | denotes | that |
T2639 | 3268-3276 | VBN | denotes | accepted |
T2638 | 3263-3267 | RB | denotes | well |
T2637 | 3260-3262 | VBZ | denotes | is |
T2636 | 3257-3259 | PRP | denotes | It |
T2635 | 3255-3256 | . | denotes | . |
T2634 | 3253-3255 | NNP | denotes | RA |
T1246 | 3048-3049 | . | denotes | . |
T1245 | 3047-3048 | NNP | denotes | ] |
T1244 | 3046-3047 | CD | denotes | 8 |
T1243 | 3045-3046 | NN | denotes | [ |
T1242 | 3032-3044 | NN | denotes | pathogenesis |
T1241 | 3029-3031 | NNP | denotes | RA |
T1240 | 3026-3028 | IN | denotes | in |
T1239 | 3015-3025 | NN | denotes | activation |
T1238 | 3009-3014 | JJ | denotes | NF-κB |
T1237 | 3006-3008 | IN | denotes | of |
T1236 | 2995-3005 | NN | denotes | importance |
T1235 | 2991-2994 | DT | denotes | the |
T1234 | 2981-2990 | NN | denotes | highlight |
T1233 | 2973-2980 | JJ | denotes | further |
T1232 | 2971-2972 | , | denotes | , |
T1231 | 2966-2971 | NNP | denotes | c-REL |
T1230 | 2962-2965 | CC | denotes | and |
T1229 | 2960-2961 | , | denotes | , |
T1228 | 2953-2960 | CD | denotes | TNFAIP3 |
T1227 | 2951-2952 | , | denotes | , |
T1226 | 2946-2951 | CD | denotes | TRAF1 |
T1225 | 2944-2945 | , | denotes | , |
T1224 | 2940-2944 | NNP | denotes | CD40 |
T1223 | 2930-2939 | VBG | denotes | including |
T1222 | 2928-2929 | , | denotes | , |
T1221 | 2918-2928 | NN | denotes | signalling |
T1220 | 2912-2917 | JJ | denotes | NF-κB |
T1219 | 2909-2911 | TO | denotes | to |
T1218 | 2900-2908 | JJ | denotes | relevant |
T1217 | 2894-2899 | NNS | denotes | genes |
T1216 | 2886-2893 | JJ | denotes | several |
T1215 | 2881-2885 | IN | denotes | with |
T1214 | 2869-2880 | NN | denotes | association |
T1213 | 2861-2868 | JJ | denotes | genetic |
T1212 | 2859-2860 | DT | denotes | a |
T1211 | 2849-2858 | VBG | denotes | revealing |
T1210 | 2837-2848 | NNS | denotes | discoveries |
T1209 | 2830-2836 | JJ | denotes | recent |
T1208 | 2828-2829 | , | denotes | , |
T1207 | 2821-2828 | RB | denotes | Finally |
T1206 | 2819-2820 | . | denotes | . |
T1205 | 2818-2819 | NNP | denotes | ] |
T1204 | 2817-2818 | CD | denotes | 7 |
T1203 | 2816-2817 | NNP | denotes | [ |
T1202 | 2813-2815 | NNP | denotes | RA |
T1201 | 2810-2812 | IN | denotes | as |
T1200 | 2805-2809 | JJ | denotes | such |
T1132 | 2410-2412 | TO | denotes | to |
T1131 | 2402-2409 | VBZ | denotes | appears |
T1130 | 2391-2401 | NN | denotes | activation |
T1129 | 2385-2390 | JJ | denotes | NF-κB |
T1128 | 2382-2384 | IN | denotes | of |
T1127 | 2375-2381 | NN | denotes | course |
T1126 | 2370-2374 | NN | denotes | time |
T1125 | 2366-2369 | DT | denotes | The |
T1124 | 2364-2365 | . | denotes | . |
T1123 | 2363-2364 | -RRB- | denotes | ) |
T1122 | 2362-2363 | NNP | denotes | ] |
T1121 | 2361-2362 | CD | denotes | 4 |
T1120 | 2360-2361 | NNP | denotes | [ |
T1119 | 2357-2359 | IN | denotes | in |
T1118 | 2348-2356 | VBN | denotes | reviewed |
T1117 | 2347-2348 | -LRB- | denotes | ( |
T1116 | 2344-2346 | NNP | denotes | RA |
T1115 | 2341-2343 | IN | denotes | of |
T1114 | 2329-2340 | NN | denotes | progression |
T1113 | 2325-2328 | CC | denotes | and |
T1112 | 2313-2324 | NN | denotes | development |
T1111 | 2309-2312 | DT | denotes | the |
T1110 | 2306-2308 | IN | denotes | in |
T1109 | 2300-2305 | NN | denotes | NF-κB |
T1108 | 2297-2299 | IN | denotes | of |
T1107 | 2292-2296 | NN | denotes | role |
T1106 | 2285-2291 | JJ | denotes | active |
T1105 | 2281-2284 | DT | denotes | the |
T1104 | 2269-2280 | VBP | denotes | demonstrate |
T1103 | 2264-2268 | RB | denotes | also |
T1102 | 2254-2263 | NNS | denotes | arthritis |
T1101 | 2241-2253 | JJ | denotes | inflammatory |
T1100 | 2238-2240 | IN | denotes | of |
T1099 | 2231-2237 | NNS | denotes | models |
T1098 | 2224-2230 | NN | denotes | animal |
T1097 | 2220-2223 | CC | denotes | and |
T1096 | 2218-2219 | , | denotes | , |
T1095 | 2210-2218 | NNS | denotes | patients |
T1094 | 2207-2209 | NNP | denotes | RA |
T1093 | 2202-2206 | IN | denotes | from |
T1092 | 2195-2201 | NN | denotes | tissue |
T1091 | 2186-2194 | JJ | denotes | synovial |
T1090 | 2182-2185 | CC | denotes | and |
T1089 | 2170-2181 | NNS | denotes | fibroblasts |
T1088 | 2161-2169 | JJ | denotes | synovial |
T1087 | 2152-2160 | JJ | denotes | cultured |
T1086 | 2149-2151 | IN | denotes | in |
T1085 | 2140-2148 | VBN | denotes | detected |
T1084 | 2137-2139 | VB | denotes | be |
T1083 | 2133-2136 | MD | denotes | can |
T1082 | 2122-2132 | NN | denotes | activation |
T1081 | 2116-2121 | JJ | denotes | NF-κB |
T1080 | 2114-2115 | . | denotes | . |
T1079 | 2113-2114 | -RRB- | denotes | ) |
T1078 | 2112-2113 | NNP | denotes | ] |
T1077 | 2109-2112 | CD | denotes | 2,3 |
T1076 | 2108-2109 | NNP | denotes | [ |
T1075 | 2105-2107 | IN | denotes | in |
T1074 | 2096-2104 | VBN | denotes | reviewed |
T1073 | 2095-2096 | -LRB- | denotes | ( |
T1072 | 2089-2094 | NNP | denotes | NF-κB |
T1071 | 2086-2088 | IN | denotes | of |
T1070 | 2075-2085 | NNS | denotes | activators |
T1069 | 2068-2074 | JJ | denotes | potent |
T1068 | 2063-2067 | RB | denotes | very |
T1067 | 2052-2062 | PRP | denotes | themselves |
T1066 | 2048-2051 | VBP | denotes | are |
T1065 | 2043-2047 | NNP | denotes | IL-1 |
T1064 | 2039-2042 | CC | denotes | and |
T1063 | 2035-2038 | NNP | denotes | TNF |
T1062 | 2033-2034 | , | denotes | , |
T1061 | 2025-2033 | NN | denotes | addition |
T1060 | 2022-2024 | IN | denotes | In |
T1059 | 2020-2021 | . | denotes | . |
T1058 | 2018-2020 | NNP | denotes | RA |
T1057 | 2015-2017 | IN | denotes | in |
T1056 | 2006-2014 | VBN | denotes | involved |
T1055 | 2002-2005 | VBP | denotes | are |
T1054 | 1997-2001 | WDT | denotes | that |
T1053 | 1995-1996 | : | denotes | - |
T1052 | 1976-1994 | NNS | denotes | metalloproteinases |
T1051 | 1969-1975 | NN | denotes | matrix |
T1050 | 1965-1968 | CC | denotes | and |
T1049 | 1963-1964 | , | denotes | , |
T1048 | 1955-1963 | NN | denotes | synthase |
T1047 | 1949-1954 | NN | denotes | oxide |
T1046 | 1942-1948 | JJ | denotes | nitric |
T1045 | 1932-1941 | JJ | denotes | inducible |
T1044 | 1930-1931 | , | denotes | , |
T1043 | 1920-1930 | NNS | denotes | chemokines |
T1042 | 1918-1919 | , | denotes | , |
T1041 | 1901-1918 | JJ | denotes | cyclo-oxygenase-2 |
T1040 | 1899-1900 | , | denotes | , |
T1039 | 1895-1899 | NNP | denotes | IL-6 |
T1038 | 1893-1894 | , | denotes | , |
T1037 | 1889-1893 | NNP | denotes | IL-1 |
T1036 | 1887-1888 | , | denotes | , |
T1035 | 1884-1887 | NNP | denotes | TNF |
T1034 | 1881-1883 | IN | denotes | as |
T1033 | 1876-1880 | JJ | denotes | such |
T1032 | 1874-1875 | : | denotes | - |
T1031 | 1868-1873 | NNS | denotes | genes |
T1030 | 1865-1867 | IN | denotes | of |
T1029 | 1858-1864 | NN | denotes | number |
T1028 | 1852-1857 | JJ | denotes | large |
T1027 | 1850-1851 | DT | denotes | a |
T1026 | 1847-1849 | IN | denotes | of |
T1025 | 1836-1846 | NN | denotes | expression |
T1024 | 1832-1835 | DT | denotes | the |
T1023 | 1823-1831 | VB | denotes | regulate |
T1022 | 1818-1822 | IN | denotes | that |
T1021 | 1814-1817 | CC | denotes | and |
T1020 | 1812-1813 | , | denotes | , |
T1019 | 1811-1812 | NNP | denotes | ] |
T1018 | 1810-1811 | CD | denotes | 1 |
T1017 | 1809-1810 | VBP | denotes | [ |
T1016 | 1796-1808 | NNS | denotes | heterodimers |
T1015 | 1793-1795 | CC | denotes | or |
T1014 | 1782-1792 | NNS | denotes | homodimers |
T1013 | 1779-1781 | IN | denotes | as |
T1012 | 1770-1778 | VBP | denotes | function |
T1011 | 1765-1769 | WDT | denotes | that |
T1010 | 1763-1764 | -RRB- | denotes | ) |
T1009 | 1758-1763 | NNP | denotes | c-Rel |
T1008 | 1756-1757 | , | denotes | , |
T1007 | 1752-1756 | NNP | denotes | RelB |
T1006 | 1750-1751 | , | denotes | , |
T1005 | 1746-1750 | NNP | denotes | RelA |
T1004 | 1743-1745 | CC | denotes | or |
T1003 | 1739-1742 | CD | denotes | p65 |
T1002 | 1737-1738 | , | denotes | , |
T1001 | 1731-1737 | NNP | denotes | NF-κB1 |
T1000 | 1728-1730 | CC | denotes | or |
T999 | 1723-1727 | CD | denotes | p105 |
T998 | 1721-1722 | , | denotes | , |
T997 | 1715-1721 | NNP | denotes | NF-κB2 |
T996 | 1712-1714 | CC | denotes | or |
T995 | 1707-1711 | CD | denotes | p100 |
T994 | 1706-1707 | -LRB- | denotes | ( |
T993 | 1697-1705 | NNS | denotes | proteins |
T992 | 1687-1696 | VBD | denotes | conserved |
T991 | 1672-1686 | RB | denotes | evolutionarily |
T990 | 1668-1671 | CC | denotes | and |
T989 | 1660-1667 | VBN | denotes | related |
T988 | 1647-1659 | RB | denotes | structurally |
T987 | 1644-1646 | IN | denotes | of |
T986 | 1637-1643 | NN | denotes | family |
T985 | 1635-1636 | DT | denotes | a |
T984 | 1624-1634 | VBZ | denotes | represents |
T983 | 1618-1623 | NN | denotes | NF-κB |
T982 | 1616-1617 | . | denotes | . |
T981 | 1608-1616 | NNS | denotes | diseases |
T980 | 1597-1607 | JJ | denotes | autoimmune |
T979 | 1591-1596 | JJ | denotes | other |
T978 | 1586-1590 | JJ | denotes | many |
T977 | 1582-1585 | CC | denotes | and |
T976 | 1579-1581 | NNP | denotes | RA |
T975 | 1576-1578 | IN | denotes | of |
T974 | 1564-1575 | NN | denotes | development |
T973 | 1560-1563 | DT | denotes | the |
T972 | 1557-1559 | IN | denotes | in |
T971 | 1552-1556 | NN | denotes | role |
T970 | 1548-1551 | JJ | denotes | key |
T969 | 1546-1547 | DT | denotes | a |
T968 | 1540-1545 | VBZ | denotes | plays |
T967 | 1529-1539 | NN | denotes | expression |
T966 | 1524-1528 | NN | denotes | gene |
T965 | 1508-1523 | JJ | denotes | NF-κB-dependent |
T964 | 1505-1507 | IN | denotes | of |
T963 | 1494-1504 | NN | denotes | activation |
T962 | 1489-1493 | IN | denotes | that |
T961 | 1480-1488 | VBN | denotes | accepted |
T960 | 1475-1479 | RB | denotes | well |
T959 | 1472-1474 | VBZ | denotes | is |
T958 | 1469-1471 | PRP | denotes | it |
T957 | 1465-1468 | CC | denotes | but |
T956 | 1463-1464 | , | denotes | , |
T955 | 1453-1463 | VBN | denotes | understood |
T954 | 1449-1452 | RB | denotes | not |
T953 | 1443-1448 | RB | denotes | still |
T952 | 1440-1442 | VBZ | denotes | is |
T951 | 1437-1439 | NNP | denotes | RA |
T950 | 1434-1436 | IN | denotes | of |
T949 | 1424-1433 | NN | denotes | aetiology |
T948 | 1420-1423 | DT | denotes | The |
T947 | 1418-1419 | . | denotes | . |
T946 | 1414-1418 | NN | denotes | bone |
T945 | 1402-1413 | JJ | denotes | subchondral |
T944 | 1398-1401 | CC | denotes | and |
T943 | 1388-1397 | NN | denotes | cartilage |
T942 | 1378-1387 | JJ | denotes | articular |
T941 | 1369-1377 | VBZ | denotes | degrades |
T940 | 1365-1368 | CC | denotes | and |
T939 | 1357-1364 | VBZ | denotes | invades |
T938 | 1351-1356 | WDT | denotes | which |
T937 | 1349-1350 | , | denotes | , |
T936 | 1343-1349 | NN | denotes | tissue |
T935 | 1336-1342 | NN | denotes | pannus |
T934 | 1333-1335 | IN | denotes | of |
T933 | 1323-1332 | NN | denotes | formation |
T932 | 1319-1322 | DT | denotes | the |
T931 | 1316-1318 | TO | denotes | to |
T883 | 993-1003 | NN | denotes | disability |
T882 | 989-992 | CC | denotes | and |
T881 | 981-988 | NN | denotes | decline |
T880 | 970-980 | JJ | denotes | functional |
T879 | 967-969 | TO | denotes | to |
T878 | 959-966 | VBG | denotes | leading |
T877 | 957-958 | , | denotes | , |
T876 | 953-957 | NN | denotes | bone |
T875 | 949-952 | CC | denotes | and |
T874 | 939-948 | NN | denotes | cartilage |
T873 | 936-938 | IN | denotes | of |
T872 | 924-935 | NN | denotes | destruction |
T871 | 912-923 | JJ | denotes | progressive |
T870 | 910-911 | DT | denotes | a |
T869 | 905-909 | IN | denotes | with |
T868 | 894-904 | VBN | denotes | associated |
T867 | 891-893 | VBZ | denotes | is |
T833 | 698-707 | NNS | denotes | arthritis |
T832 | 687-697 | JJ | denotes | Rheumatoid |
T1199 | 2796-2804 | NNS | denotes | diseases |
T1198 | 2785-2795 | JJ | denotes | osteolytic |
T1197 | 2782-2784 | IN | denotes | in |
T1196 | 2774-2781 | NN | denotes | erosion |
T1195 | 2769-2773 | NN | denotes | bone |
T1194 | 2766-2768 | IN | denotes | of |
T1193 | 2760-2765 | NN | denotes | cause |
T1192 | 2754-2759 | JJ | denotes | major |
T1191 | 2750-2753 | DT | denotes | the |
T1190 | 2746-2749 | VBP | denotes | are |
T1189 | 2727-2745 | NN | denotes | osteoclastogenesis |
T1188 | 2724-2726 | IN | denotes | of |
T1187 | 2713-2723 | NN | denotes | regulation |
T1186 | 2709-2712 | DT | denotes | the |
T1185 | 2706-2708 | IN | denotes | in |
T1184 | 2698-2705 | NNS | denotes | Defects |
T1183 | 2696-2697 | . | denotes | . |
T1182 | 2695-2696 | -RRB- | denotes | ) |
T1181 | 2690-2695 | NNP | denotes | RANKL |
T1180 | 2689-2690 | -LRB- | denotes | ( |
T1179 | 2682-2688 | NN | denotes | ligand |
T1178 | 2676-2681 | JJ | denotes | NF-κB |
T1177 | 2673-2675 | IN | denotes | of |
T1176 | 2663-2672 | NN | denotes | activator |
T1175 | 2654-2662 | NN | denotes | receptor |
T1174 | 2651-2653 | IN | denotes | of |
T1173 | 2643-2650 | NNS | denotes | effects |
T1172 | 2639-2642 | DT | denotes | the |
T1171 | 2629-2638 | VBG | denotes | mediating |
T1170 | 2626-2628 | IN | denotes | by |
T1169 | 2619-2625 | RB | denotes | mainly |
T1168 | 2617-2618 | , | denotes | , |
T1167 | 2599-2617 | NN | denotes | osteoclastogenesis |
T1166 | 2595-2598 | IN | denotes | for |
T1165 | 2585-2594 | JJ | denotes | essential |
T1164 | 2580-2584 | RB | denotes | also |
T1163 | 2577-2579 | VBZ | denotes | is |
T1162 | 2571-2576 | NNP | denotes | NF-κB |
T1161 | 2569-2570 | , | denotes | , |
T1160 | 2559-2569 | NN | denotes | expression |
T1159 | 2554-2558 | NN | denotes | gene |
T1158 | 2538-2553 | JJ | denotes | proinflammatory |
T1157 | 2535-2537 | IN | denotes | in |
T1156 | 2530-2534 | NN | denotes | role |
T1155 | 2526-2529 | PRP$ | denotes | its |
T1154 | 2523-2525 | TO | denotes | to |
T1153 | 2518-2522 | JJ | denotes | Next |
T1152 | 2516-2517 | . | denotes | . |
T1151 | 2515-2516 | NNP | denotes | ] |
T1150 | 2512-2515 | CD | denotes | 5,6 |
T1149 | 2511-2512 | NNP | denotes | [ |
T1148 | 2502-2510 | NN | denotes | severity |
T1147 | 2494-2501 | NN | denotes | disease |
T1146 | 2484-2493 | VBZ | denotes | decreases |
T1145 | 2478-2483 | NNS | denotes | means |
T1144 | 2468-2477 | JJ | denotes | different |
T1143 | 2465-2467 | IN | denotes | by |
T1142 | 2459-2464 | NN | denotes | NF-κB |
T1141 | 2456-2458 | IN | denotes | of |
T1140 | 2447-2455 | NN | denotes | blockade |
T1139 | 2443-2446 | CC | denotes | and |
T1138 | 2441-2442 | , | denotes | , |
T1137 | 2434-2441 | NN | denotes | disease |
T1136 | 2431-2433 | IN | denotes | of |
T1135 | 2425-2430 | NN | denotes | onset |
T1134 | 2421-2424 | DT | denotes | the |
T1133 | 2413-2420 | VB | denotes | precede |
T210 | 671-672 | . | denotes | . |
T209 | 662-671 | NNS | denotes | arthritis |
T208 | 651-661 | JJ | denotes | rheumatoid |
T207 | 648-650 | IN | denotes | of |
T206 | 635-647 | NN | denotes | pathogenesis |
T205 | 631-634 | DT | denotes | the |
T204 | 628-630 | IN | denotes | in |
T203 | 617-627 | VBN | denotes | implicated |
T202 | 612-616 | VBN | denotes | been |
T201 | 607-611 | VBP | denotes | have |
T200 | 601-606 | WDT | denotes | which |
T199 | 597-600 | CC | denotes | and |
T198 | 586-596 | NN | denotes | signalling |
T197 | 580-585 | JJ | denotes | NF-κB |
T196 | 572-579 | VB | denotes | control |
T195 | 569-571 | TO | denotes | to |
T194 | 561-568 | VBN | denotes | evolved |
T193 | 556-560 | VBP | denotes | have |
T192 | 551-555 | WDT | denotes | that |
T191 | 540-550 | NNS | denotes | mechanisms |
T190 | 529-539 | JJ | denotes | regulatory |
T189 | 520-528 | JJ | denotes | negative |
T188 | 512-519 | JJ | denotes | various |
T187 | 505-511 | VB | denotes | review |
T186 | 500-504 | MD | denotes | will |
T185 | 497-499 | PRP | denotes | we |
T184 | 492-496 | RB | denotes | Here |
T183 | 490-491 | . | denotes | . |
T182 | 481-490 | NNS | denotes | responses |
T181 | 475-480 | JJ | denotes | NF-κB |
T180 | 472-474 | IN | denotes | of |
T179 | 460-471 | NN | denotes | termination |
T178 | 451-459 | VBG | denotes | ensuring |
T177 | 440-450 | NNS | denotes | regulators |
T176 | 431-439 | NN | denotes | feedback |
T175 | 422-430 | JJ | denotes | negative |
T174 | 419-421 | IN | denotes | of |
T173 | 408-418 | NN | denotes | repertoire |
T172 | 406-407 | DT | denotes | a |
T171 | 396-405 | VBG | denotes | including |
T170 | 394-395 | , | denotes | , |
T169 | 389-394 | NN | denotes | check |
T168 | 386-388 | IN | denotes | in |
T167 | 375-385 | NN | denotes | signalling |
T166 | 369-374 | JJ | denotes | NF-κB |
T165 | 364-368 | VB | denotes | keep |
T164 | 361-363 | TO | denotes | to |
T163 | 354-360 | NN | denotes | system |
T162 | 346-353 | NN | denotes | control |
T161 | 333-345 | JJ | denotes | multilayered |
T160 | 331-332 | DT | denotes | a |
T159 | 324-330 | VBP | denotes | employ |
T158 | 318-323 | NNS | denotes | Cells |
T157 | 316-317 | . | denotes | . |
T156 | 307-316 | NNS | denotes | arthritis |
T155 | 296-306 | JJ | denotes | rheumatoid |
T154 | 286-295 | VBG | denotes | including |
T153 | 284-285 | , | denotes | , |
T152 | 276-284 | NNS | denotes | diseases |
T151 | 263-275 | JJ | denotes | inflammatory |
T150 | 259-262 | CC | denotes | and |
T149 | 248-258 | JJ | denotes | autoimmune |
T148 | 243-247 | JJ | denotes | many |
T147 | 238-242 | IN | denotes | with |
T146 | 231-237 | VBN | denotes | linked |
T145 | 226-230 | VBN | denotes | been |
T144 | 222-225 | VBZ | denotes | has |
T143 | 213-221 | NN | denotes | activity |
T142 | 207-212 | NN | denotes | NF-κB |
T141 | 193-206 | JJ | denotes | inappropriate |
T140 | 189-192 | CC | denotes | and |
T139 | 187-188 | , | denotes | , |
T138 | 178-187 | NNS | denotes | responses |
T137 | 172-177 | NN | denotes | mmune |
T136 | 168-171 | CC | denotes | and |
T135 | 155-167 | NN | denotes | inflammation |
T134 | 152-154 | IN | denotes | of |
T133 | 141-151 | NN | denotes | regulation |
T132 | 137-140 | DT | denotes | the |
T131 | 134-136 | IN | denotes | in |
T130 | 128-133 | NNS | denotes | roles |
T129 | 120-127 | JJ | denotes | crucial |
T128 | 114-119 | VBZ | denotes | plays |
T127 | 108-113 | NNP | denotes | NF-κB |
T126 | 101-107 | NN | denotes | factor |
T125 | 87-100 | NN | denotes | transcription |
T124 | 83-86 | DT | denotes | The |
T843 | 754-755 | , | denotes | , |
T842 | 745-754 | NNS | denotes | arthritis |
T841 | 732-744 | JJ | denotes | inflammatory |
T866 | 884-890 | NNS | denotes | joints |
T865 | 881-883 | IN | denotes | of |
T864 | 868-880 | NN | denotes | inflammation |
T863 | 860-867 | JJ | denotes | chronic |
T862 | 854-859 | WDT | denotes | which |
T861 | 851-853 | IN | denotes | in |
T860 | 837-850 | NN | denotes | polyarthritis |
T859 | 825-836 | JJ | denotes | symmetrical |
T858 | 823-824 | DT | denotes | a |
T857 | 820-822 | IN | denotes | by |
T856 | 806-819 | VBN | denotes | characterised |
T855 | 803-805 | VBZ | denotes | is |
T854 | 800-802 | NNP | denotes | RA |
T853 | 798-799 | . | denotes | . |
T852 | 788-798 | NN | denotes | population |
T851 | 782-787 | NN | denotes | adult |
T850 | 778-781 | DT | denotes | the |
T849 | 775-777 | IN | denotes | of |
T848 | 773-774 | NN | denotes | % |
T847 | 772-773 | CD | denotes | 1 |
T846 | 769-771 | TO | denotes | to |
T845 | 766-768 | RP | denotes | up |
T844 | 756-765 | VBG | denotes | affecting |
T840 | 725-731 | JJ | denotes | common |
T839 | 720-724 | RBS | denotes | most |
T838 | 716-719 | DT | denotes | the |
T837 | 713-715 | VBZ | denotes | is |
T836 | 711-712 | -RRB- | denotes | ) |
T835 | 709-711 | NNP | denotes | RA |
T834 | 708-709 | -LRB- | denotes | ( |
T930 | 1310-1315 | VBZ | denotes | leads |
T929 | 1298-1309 | NNS | denotes | fibroblasts |
T928 | 1289-1297 | JJ | denotes | synovial |
T927 | 1286-1288 | IN | denotes | of |
T926 | 1272-1285 | NNP | denotes | Proliferation |
T925 | 1270-1271 | . | denotes | . |
T924 | 1265-1270 | NNS | denotes | cells |
T923 | 1256-1264 | JJ | denotes | synovial |
T922 | 1252-1255 | CC | denotes | and |
T921 | 1242-1251 | NNS | denotes | monocytes |
T920 | 1229-1241 | VBG | denotes | infiltrating |
T919 | 1226-1228 | IN | denotes | by |
T918 | 1207-1225 | NNS | denotes | metalloproteinases |
T917 | 1200-1206 | NN | denotes | matrix |
T908 | 1152-1155 | CC | denotes | and |
T907 | 1150-1151 | CD | denotes | 1 |
T906 | 1145-1149 | NN | denotes | type |
T905 | 1136-1144 | NN | denotes | T-helper |
T904 | 1120-1135 | JJ | denotes | proinflammatory |
T903 | 1117-1119 | IN | denotes | of |
T902 | 1106-1116 | NN | denotes | production |
T901 | 1100-1105 | JJ | denotes | local |
T900 | 1096-1099 | DT | denotes | the |
T899 | 1089-1095 | VBZ | denotes | drives |
T898 | 1083-1088 | NN | denotes | space |
T897 | 1077-1082 | JJ | denotes | joint |
T896 | 1073-1076 | DT | denotes | the |
T895 | 1068-1072 | IN | denotes | into |
T894 | 1061-1067 | NN | denotes | system |
T893 | 1054-1060 | JJ | denotes | immune |
T892 | 1045-1053 | JJ | denotes | adaptive |
T891 | 1041-1044 | CC | denotes | and |
T890 | 1034-1040 | NN | denotes | innate |
T889 | 1030-1033 | DT | denotes | the |
T888 | 1027-1029 | IN | denotes | of |
T887 | 1021-1026 | NNS | denotes | cells |
T886 | 1018-1020 | IN | denotes | of |
T885 | 1005-1017 | NNP | denotes | Infiltration |
T884 | 1003-1004 | . | denotes | . |
T916 | 1196-1199 | CC | denotes | and |
T915 | 1194-1195 | , | denotes | , |
T914 | 1184-1194 | NNS | denotes | chemokines |
T913 | 1182-1183 | , | denotes | , |
T912 | 1173-1182 | NNS | denotes | cytokines |
T911 | 1170-1172 | CD | denotes | 17 |
T910 | 1165-1169 | NN | denotes | type |
T909 | 1156-1164 | NNP | denotes | T-helper |
T16982 | 30108-30109 | . | denotes | . |
T16981 | 30107-30108 | NNP | denotes | ] |
T18051 | 30305-30310 | NN | denotes | class |
T18050 | 30303-30304 | DT | denotes | a |
T18049 | 30293-30302 | VB | denotes | represent |
T18048 | 30289-30292 | CC | denotes | and |
T18047 | 30278-30288 | NN | denotes | expression |
T18046 | 30273-30277 | NN | denotes | gene |
T18045 | 30270-30272 | IN | denotes | of |
T18044 | 30259-30269 | NNS | denotes | regulators |
T18043 | 30248-30258 | VBN | denotes | discovered |
T18042 | 30239-30247 | RB | denotes | recently |
T18041 | 30235-30238 | VBP | denotes | are |
T18040 | 30228-30234 | NNS | denotes | miRNAs |
T18039 | 30218-30227 | NNS | denotes | microRNAs |
T17002 | 30215-30216 | . | denotes | . |
T17001 | 30214-30215 | NNP | denotes | ] |
T17000 | 30212-30214 | CD | denotes | 76 |
T16999 | 30211-30212 | NNP | denotes | [ |
T16998 | 30208-30210 | NNP | denotes | RA |
T16997 | 30203-30207 | IN | denotes | with |
T16996 | 30196-30202 | NN | denotes | region |
T16995 | 30190-30195 | CD | denotes | TRAF1 |
T16994 | 30186-30189 | DT | denotes | the |
T16993 | 30183-30185 | IN | denotes | of |
T16992 | 30171-30182 | NN | denotes | association |
T16991 | 30163-30170 | JJ | denotes | genetic |
T16990 | 30150-30162 | VBZ | denotes | demonstrates |
T16989 | 30145-30149 | RB | denotes | also |
T16988 | 30134-30144 | NN | denotes | population |
T16987 | 30127-30133 | JJ | denotes | Korean |
T16986 | 30125-30126 | DT | denotes | a |
T16985 | 30122-30124 | IN | denotes | in |
T16984 | 30117-30121 | NN | denotes | work |
T16983 | 30110-30116 | JJ | denotes | Recent |
T16980 | 30105-30107 | CD | denotes | 75 |
T16979 | 30104-30105 | NNP | denotes | [ |
T16978 | 30098-30103 | NN | denotes | locus |
T16977 | 30088-30097 | JJ | denotes | causative |
T16976 | 30084-30087 | DT | denotes | the |
T18094 | 30569-30570 | NNP | denotes | [ |
T18093 | 30557-30568 | NN | denotes | degradation |
T18092 | 30552-30556 | NNP | denotes | mRNA |
T18091 | 30545-30551 | NN | denotes | target |
T18090 | 30542-30544 | IN | denotes | of |
T18089 | 30532-30541 | NN | denotes | promotion |
T18088 | 30528-30531 | DT | denotes | the |
T18087 | 30524-30527 | CC | denotes | and |
T18086 | 30513-30523 | NN | denotes | expression |
T18085 | 30505-30512 | NN | denotes | protein |
T18084 | 30502-30504 | IN | denotes | of |
T18083 | 30491-30501 | NN | denotes | repression |
T18082 | 30487-30490 | DT | denotes | the |
T18081 | 30484-30486 | TO | denotes | to |
T18080 | 30476-30483 | VBG | denotes | leading |
T18079 | 30470-30475 | NNS | denotes | mRNAs |
T18078 | 30463-30469 | NN | denotes | target |
T18077 | 30460-30462 | IN | denotes | of |
T18076 | 30456-30459 | NNP | denotes | UTR |
T18075 | 30455-30456 | : | denotes | - |
T18074 | 30454-30455 | '' | denotes | ' |
T18073 | 30453-30454 | CD | denotes | 3 |
T18072 | 30449-30452 | DT | denotes | the |
T18071 | 30444-30448 | NN | denotes | bind |
T18070 | 30439-30443 | PRP | denotes | They |
T18069 | 30437-30438 | . | denotes | . |
T18068 | 30425-30437 | NN | denotes | inflammation |
T18067 | 30421-30424 | CC | denotes | and |
T18066 | 30411-30420 | NNS | denotes | responses |
T18065 | 30404-30410 | JJ | denotes | immune |
T18064 | 30394-30403 | VBG | denotes | including |
T18063 | 30392-30393 | , | denotes | , |
T18062 | 30383-30392 | NNS | denotes | processes |
T18061 | 30369-30382 | JJ | denotes | developmental |
T18060 | 30365-30368 | CC | denotes | and |
T18059 | 30356-30364 | JJ | denotes | cellular |
T18058 | 30351-30355 | JJ | denotes | many |
T18057 | 30348-30350 | IN | denotes | in |
T18056 | 30338-30347 | JJ | denotes | essential |
T18055 | 30328-30337 | NNS | denotes | molecules |
T18054 | 30324-30327 | NNP | denotes | RNA |
T18053 | 30314-30323 | VBG | denotes | noncoding |
T18052 | 30311-30313 | IN | denotes | of |
T18233 | 31287-31291 | IN | denotes | from |
T18232 | 31281-31286 | NNS | denotes | cells |
T18231 | 31279-31280 | NN | denotes | T |
T18230 | 31263-31278 | JJ | denotes | IL-17-producing |
T18229 | 31259-31262 | CC | denotes | and |
T18228 | 31257-31258 | NNP | denotes | + |
T18227 | 31254-31257 | NNP | denotes | CD4 |
T18226 | 31251-31253 | IN | denotes | in |
T18225 | 31237-31250 | VBN | denotes | overexpressed |
T18224 | 31232-31236 | RB | denotes | also |
T18223 | 31229-31231 | VBZ | denotes | is |
T18222 | 31220-31228 | NN | denotes | miR-146a |
T18221 | 31218-31219 | . | denotes | . |
T18220 | 31217-31218 | NNP | denotes | ] |
T18219 | 31215-31217 | CD | denotes | 83 |
T18218 | 31214-31215 | NNP | denotes | [ |
T18217 | 31205-31213 | NNS | denotes | patients |
T18216 | 31202-31204 | NNP | denotes | RA |
T18215 | 31199-31201 | IN | denotes | of |
T18214 | 31193-31198 | NNS | denotes | cells |
T18213 | 31181-31192 | NN | denotes | mononuclear |
T18212 | 31175-31180 | NN | denotes | blood |
T18211 | 31164-31174 | JJ | denotes | peripheral |
T18210 | 31161-31163 | IN | denotes | in |
T18209 | 31158-31160 | IN | denotes | as |
T18208 | 31153-31157 | RB | denotes | well |
T18207 | 31150-31152 | RB | denotes | as |
T18291 | 31632-31634 | NNP | denotes | RA |
T18290 | 31629-31631 | IN | denotes | in |
T18289 | 31617-31628 | NN | denotes | destruction |
T18288 | 31610-31616 | NN | denotes | tissue |
T18287 | 31602-31609 | VBP | denotes | mediate |
T18286 | 31597-31601 | WDT | denotes | that |
T18285 | 31578-31596 | NNS | denotes | metalloproteinases |
T18284 | 31571-31577 | NN | denotes | matrix |
T18283 | 31562-31570 | JJ | denotes | specific |
T18282 | 31559-31561 | IN | denotes | of |
T18281 | 31548-31558 | NN | denotes | expression |
T18280 | 31529-31547 | JJ | denotes | cytokine-inducible |
T18279 | 31525-31528 | CC | denotes | and |
T21924 | 14278-14279 | , | denotes | , |
T21923 | 14270-14278 | NN | denotes | receptor |
T21922 | 14266-14269 | DT | denotes | the |
T21921 | 14263-14265 | TO | denotes | to |
T21920 | 14253-14262 | VBN | denotes | recruited |
T21919 | 14250-14252 | VBZ | denotes | is |
T21918 | 14244-14249 | CD | denotes | TRAF3 |
T21917 | 14242-14243 | , | denotes | , |
T21916 | 14235-14242 | JJ | denotes | binding |
T21915 | 14228-14234 | JJ | denotes | ligand |
T21914 | 14223-14227 | IN | denotes | Upon |
T21913 | 14221-14222 | . | denotes | . |
T21912 | 14218-14221 | JJ | denotes | low |
T21911 | 14211-14217 | NNS | denotes | levels |
T21910 | 14207-14210 | NNP | denotes | NIK |
T21909 | 14199-14206 | VBG | denotes | keeping |
T21908 | 14197-14198 | , | denotes | , |
T21907 | 14194-14197 | NNP | denotes | NIK |
T21906 | 14191-14193 | IN | denotes | of |
T21905 | 14179-14190 | NN | denotes | degradation |
T21904 | 14167-14178 | JJ | denotes | proteasomal |
T21903 | 14163-14166 | CC | denotes | and |
T21947 | 14459-14460 | , | denotes | , |
T21946 | 14454-14459 | CD | denotes | TRAF3 |
T21945 | 14451-14453 | TO | denotes | to |
T21944 | 14432-14450 | NN | denotes | polyubiquitination |
T21943 | 14421-14431 | JJ | denotes | K48-linked |
T21942 | 14417-14420 | PRP$ | denotes | its |
T21941 | 14409-14416 | VBZ | denotes | directs |
T21940 | 14401-14408 | JJ | denotes | cIAP1/2 |
T21939 | 14388-14400 | RB | denotes | Subsequently |
T21938 | 14386-14387 | . | denotes | . |
T21937 | 14376-14386 | NN | denotes | activation |
T21936 | 14370-14375 | PRP$ | denotes | their |
T21935 | 14367-14369 | IN | denotes | in |
T21934 | 14357-14366 | VBG | denotes | resulting |
T21933 | 14355-14356 | , | denotes | , |
T21932 | 14348-14355 | NNP | denotes | cIAP1/2 |
T21931 | 14345-14347 | IN | denotes | of |
T21930 | 14326-14344 | NN | denotes | polyubiquitination |
T21929 | 14315-14325 | JJ | denotes | K63-linked |
T21928 | 14300-14314 | JJ | denotes | nondegradative |
T21927 | 14292-14299 | VBZ | denotes | directs |
T21926 | 14286-14291 | CD | denotes | TRAF2 |
T21925 | 14280-14285 | WRB | denotes | where |
R3979 | T5917 | T5918 | compound | NF-κB,proteins |
R5921 | T8787 | T8790 | mark | Since,is |
R7232 | T10859 | T10861 | nummod | A20,A20 |
R7233 | T10860 | T10861 | compound | protein,A20 |
R7234 | T10861 | T10868 | nsubj | A20,is |
R7235 | T10862 | T10864 | punct | (,known |
R100 | T114 | T115 | amod | Negative,regulation |
R101 | T115 | T128 | nsubj | regulation,plays |
R102 | T116 | T115 | prep | of,regulation |
R103 | T117 | T116 | pobj | NF-κB,of |
R104 | T118 | T117 | cc | and,NF-κB |
R105 | T119 | T120 | poss | its,involvement |
R106 | T120 | T115 | appos | involvement,regulation |
R107 | T121 | T120 | prep | in,involvement |
R108 | T122 | T123 | amod | rheumatoid,arthritis |
R109 | T123 | T121 | pobj | arthritis,in |
R110 | T124 | T126 | det | The,factor |
R111 | T125 | T126 | compound | transcription,factor |
R112 | T126 | T128 | nsubj | factor,plays |
R113 | T127 | T128 | nsubj | NF-κB,plays |
R114 | T128 | T128 | ROOT | plays,plays |
R115 | T129 | T130 | amod | crucial,roles |
R116 | T130 | T128 | dobj | roles,plays |
R117 | T131 | T128 | prep | in,plays |
R118 | T132 | T133 | det | the,regulation |
R119 | T133 | T131 | pobj | regulation,in |
R120 | T134 | T133 | prep | of,regulation |
R121 | T135 | T138 | nmod | inflammation,responses |
R122 | T136 | T135 | cc | and,inflammation |
R123 | T137 | T135 | conj | mmune,inflammation |
R124 | T138 | T134 | pobj | responses,of |
R125 | T139 | T133 | punct | ",",regulation |
R126 | T140 | T133 | cc | and,regulation |
R127 | T141 | T143 | amod | inappropriate,activity |
R128 | T142 | T143 | compound | NF-κB,activity |
R129 | T143 | T133 | conj | activity,regulation |
R130 | T144 | T146 | aux | has,linked |
R131 | T145 | T146 | auxpass | been,linked |
R132 | T146 | T128 | conj | linked,plays |
R133 | T147 | T146 | prep | with,linked |
R134 | T148 | T152 | amod | many,diseases |
R135 | T149 | T152 | amod | autoimmune,diseases |
R136 | T150 | T149 | cc | and,autoimmune |
R137 | T151 | T149 | conj | inflammatory,autoimmune |
R138 | T152 | T147 | pobj | diseases,with |
R139 | T153 | T152 | punct | ",",diseases |
R140 | T154 | T152 | prep | including,diseases |
R141 | T155 | T156 | amod | rheumatoid,arthritis |
R142 | T156 | T154 | pobj | arthritis,including |
R143 | T157 | T128 | punct | .,plays |
R144 | T158 | T159 | nsubj | Cells,employ |
R145 | T159 | T159 | ROOT | employ,employ |
R146 | T160 | T163 | det | a,system |
R147 | T161 | T163 | amod | multilayered,system |
R148 | T162 | T163 | compound | control,system |
R149 | T163 | T159 | dobj | system,employ |
R150 | T164 | T165 | aux | to,keep |
R151 | T165 | T163 | relcl | keep,system |
R152 | T166 | T167 | amod | NF-κB,signalling |
R153 | T167 | T165 | dobj | signalling,keep |
R154 | T168 | T165 | prep | in,keep |
R155 | T169 | T168 | pobj | check,in |
R156 | T170 | T165 | punct | ",",keep |
R157 | T171 | T165 | prep | including,keep |
R158 | T172 | T173 | det | a,repertoire |
R159 | T173 | T171 | pobj | repertoire,including |
R160 | T174 | T173 | prep | of,repertoire |
R161 | T175 | T177 | amod | negative,regulators |
R162 | T176 | T177 | compound | feedback,regulators |
R163 | T177 | T174 | pobj | regulators,of |
R164 | T178 | T173 | acl | ensuring,repertoire |
R165 | T179 | T178 | dobj | termination,ensuring |
R166 | T180 | T179 | prep | of,termination |
R167 | T181 | T182 | amod | NF-κB,responses |
R168 | T182 | T180 | pobj | responses,of |
R169 | T183 | T159 | punct | .,employ |
R170 | T184 | T187 | advmod | Here,review |
R171 | T185 | T187 | nsubj | we,review |
R172 | T186 | T187 | aux | will,review |
R173 | T187 | T187 | ROOT | review,review |
R174 | T188 | T191 | amod | various,mechanisms |
R175 | T189 | T191 | amod | negative,mechanisms |
R176 | T190 | T191 | amod | regulatory,mechanisms |
R177 | T191 | T187 | dobj | mechanisms,review |
R178 | T192 | T194 | nsubj | that,evolved |
R179 | T193 | T194 | aux | have,evolved |
R180 | T194 | T191 | relcl | evolved,mechanisms |
R181 | T195 | T196 | aux | to,control |
R182 | T196 | T194 | xcomp | control,evolved |
R183 | T197 | T198 | compound | NF-κB,signalling |
R184 | T198 | T196 | dobj | signalling,control |
R185 | T199 | T194 | cc | and,evolved |
R186 | T200 | T203 | nsubjpass | which,implicated |
R187 | T201 | T203 | aux | have,implicated |
R188 | T202 | T203 | auxpass | been,implicated |
R189 | T203 | T194 | conj | implicated,evolved |
R190 | T204 | T203 | prep | in,implicated |
R191 | T205 | T206 | det | the,pathogenesis |
R192 | T206 | T204 | pobj | pathogenesis,in |
R193 | T207 | T206 | prep | of,pathogenesis |
R194 | T208 | T209 | amod | rheumatoid,arthritis |
R195 | T209 | T207 | pobj | arthritis,of |
R196 | T210 | T187 | punct | .,review |
R642 | T832 | T833 | amod | Rheumatoid,arthritis |
R643 | T833 | T837 | nsubj | arthritis,is |
R644 | T834 | T833 | punct | (,arthritis |
R645 | T835 | T833 | appos | RA,arthritis |
R646 | T836 | T833 | punct | ),arthritis |
R647 | T837 | T837 | ROOT | is,is |
R648 | T838 | T842 | det | the,arthritis |
R649 | T839 | T840 | advmod | most,common |
R650 | T840 | T842 | amod | common,arthritis |
R651 | T841 | T842 | amod | inflammatory,arthritis |
R652 | T842 | T837 | attr | arthritis,is |
R653 | T843 | T837 | punct | ",",is |
R654 | T844 | T837 | advcl | affecting,is |
R655 | T845 | T847 | quantmod | up,1 |
R656 | T846 | T847 | quantmod | to,1 |
R657 | T847 | T848 | nummod | 1,% |
R658 | T848 | T844 | dobj | %,affecting |
R659 | T849 | T848 | prep | of,% |
R660 | T850 | T852 | det | the,population |
R661 | T851 | T852 | compound | adult,population |
R662 | T852 | T849 | pobj | population,of |
R663 | T853 | T837 | punct | .,is |
R664 | T854 | T856 | nsubjpass | RA,characterised |
R665 | T855 | T856 | auxpass | is,characterised |
R666 | T856 | T856 | ROOT | characterised,characterised |
R667 | T857 | T856 | agent | by,characterised |
R668 | T858 | T860 | det | a,polyarthritis |
R669 | T859 | T860 | amod | symmetrical,polyarthritis |
R670 | T860 | T857 | pobj | polyarthritis,by |
R671 | T861 | T868 | prep | in,associated |
R672 | T862 | T861 | pobj | which,in |
R673 | T863 | T864 | amod | chronic,inflammation |
R674 | T864 | T868 | nsubjpass | inflammation,associated |
R675 | T865 | T864 | prep | of,inflammation |
R676 | T866 | T865 | pobj | joints,of |
R677 | T867 | T868 | auxpass | is,associated |
R678 | T868 | T860 | relcl | associated,polyarthritis |
R679 | T869 | T868 | prep | with,associated |
R680 | T870 | T872 | det | a,destruction |
R681 | T871 | T872 | amod | progressive,destruction |
R682 | T872 | T869 | pobj | destruction,with |
R683 | T873 | T872 | prep | of,destruction |
R684 | T874 | T873 | pobj | cartilage,of |
R685 | T875 | T874 | cc | and,cartilage |
R686 | T876 | T874 | conj | bone,cartilage |
R687 | T877 | T872 | punct | ",",destruction |
R688 | T878 | T872 | acl | leading,destruction |
R689 | T879 | T878 | prep | to,leading |
R690 | T880 | T881 | amod | functional,decline |
R691 | T881 | T879 | pobj | decline,to |
R692 | T882 | T881 | cc | and,decline |
R693 | T883 | T881 | conj | disability,decline |
R694 | T884 | T856 | punct | .,characterised |
R695 | T885 | T899 | nsubj | Infiltration,drives |
R696 | T886 | T885 | prep | of,Infiltration |
R697 | T887 | T886 | pobj | cells,of |
R698 | T888 | T887 | prep | of,cells |
R699 | T889 | T894 | det | the,system |
R700 | T890 | T894 | amod | innate,system |
R701 | T891 | T890 | cc | and,innate |
R702 | T892 | T890 | conj | adaptive,innate |
R703 | T893 | T894 | amod | immune,system |
R704 | T894 | T888 | pobj | system,of |
R705 | T895 | T885 | prep | into,Infiltration |
R706 | T896 | T898 | det | the,space |
R707 | T897 | T898 | amod | joint,space |
R708 | T898 | T899 | nsubj | space,drives |
R709 | T899 | T899 | ROOT | drives,drives |
R710 | T900 | T902 | det | the,production |
R711 | T901 | T902 | amod | local,production |
R712 | T902 | T899 | dobj | production,drives |
R713 | T903 | T902 | prep | of,production |
R714 | T904 | T906 | amod | proinflammatory,type |
R715 | T905 | T906 | compound | T-helper,type |
R716 | T906 | T903 | pobj | type,of |
R717 | T907 | T906 | nummod | 1,type |
R718 | T908 | T906 | cc | and,type |
R719 | T909 | T910 | compound | T-helper,type |
R720 | T910 | T906 | conj | type,type |
R721 | T911 | T912 | nummod | 17,cytokines |
R722 | T912 | T906 | appos | cytokines,type |
R723 | T913 | T912 | punct | ",",cytokines |
R724 | T914 | T912 | conj | chemokines,cytokines |
R725 | T915 | T914 | punct | ",",chemokines |
R726 | T916 | T914 | cc | and,chemokines |
R727 | T917 | T918 | compound | matrix,metalloproteinases |
R728 | T918 | T914 | conj | metalloproteinases,chemokines |
R729 | T919 | T899 | prep | by,drives |
R730 | T920 | T919 | pcomp | infiltrating,by |
R731 | T921 | T920 | dobj | monocytes,infiltrating |
R732 | T922 | T921 | cc | and,monocytes |
R733 | T923 | T924 | amod | synovial,cells |
R734 | T924 | T921 | conj | cells,monocytes |
R735 | T925 | T899 | punct | .,drives |
R736 | T926 | T930 | nsubj | Proliferation,leads |
R737 | T927 | T926 | prep | of,Proliferation |
R738 | T928 | T929 | amod | synovial,fibroblasts |
R739 | T929 | T927 | pobj | fibroblasts,of |
R740 | T930 | T930 | ROOT | leads,leads |
R741 | T931 | T930 | prep | to,leads |
R742 | T932 | T933 | det | the,formation |
R743 | T933 | T931 | pobj | formation,to |
R744 | T934 | T933 | prep | of,formation |
R745 | T935 | T936 | amod | pannus,tissue |
R746 | T936 | T934 | pobj | tissue,of |
R747 | T937 | T936 | punct | ",",tissue |
R748 | T938 | T939 | nsubj | which,invades |
R749 | T939 | T936 | relcl | invades,tissue |
R750 | T940 | T939 | cc | and,invades |
R751 | T941 | T939 | conj | degrades,invades |
R752 | T942 | T943 | amod | articular,cartilage |
R753 | T943 | T941 | dobj | cartilage,degrades |
R754 | T944 | T943 | cc | and,cartilage |
R755 | T945 | T946 | amod | subchondral,bone |
R756 | T946 | T943 | conj | bone,cartilage |
R757 | T947 | T930 | punct | .,leads |
R758 | T948 | T949 | det | The,aetiology |
R759 | T949 | T952 | nsubj | aetiology,is |
R760 | T950 | T949 | prep | of,aetiology |
R761 | T951 | T950 | pobj | RA,of |
R762 | T952 | T955 | auxpass | is,understood |
R763 | T953 | T955 | advmod | still,understood |
R764 | T954 | T955 | neg | not,understood |
R765 | T955 | T955 | ROOT | understood,understood |
R766 | T956 | T955 | punct | ",",understood |
R767 | T957 | T955 | cc | but,understood |
R768 | T958 | T961 | nsubjpass | it,accepted |
R769 | T959 | T961 | auxpass | is,accepted |
R770 | T960 | T961 | advmod | well,accepted |
R771 | T961 | T955 | conj | accepted,understood |
R772 | T962 | T968 | mark | that,plays |
R773 | T963 | T968 | nsubj | activation,plays |
R774 | T964 | T963 | prep | of,activation |
R775 | T965 | T967 | amod | NF-κB-dependent,expression |
R776 | T966 | T967 | compound | gene,expression |
R777 | T967 | T964 | pobj | expression,of |
R778 | T968 | T961 | ccomp | plays,accepted |
R779 | T969 | T971 | det | a,role |
R780 | T970 | T971 | amod | key,role |
R781 | T971 | T968 | dobj | role,plays |
R782 | T972 | T971 | prep | in,role |
R783 | T973 | T974 | det | the,development |
R784 | T974 | T972 | pobj | development,in |
R785 | T975 | T974 | prep | of,development |
R786 | T976 | T975 | pobj | RA,of |
R787 | T977 | T974 | cc | and,development |
R788 | T978 | T981 | amod | many,diseases |
R789 | T979 | T981 | amod | other,diseases |
R790 | T980 | T981 | amod | autoimmune,diseases |
R791 | T981 | T974 | conj | diseases,development |
R792 | T982 | T961 | punct | .,accepted |
R793 | T983 | T984 | nsubj | NF-κB,represents |
R794 | T984 | T984 | ROOT | represents,represents |
R795 | T985 | T986 | det | a,family |
R796 | T986 | T984 | dobj | family,represents |
R797 | T987 | T986 | prep | of,family |
R798 | T988 | T989 | advmod | structurally,related |
R799 | T989 | T987 | pcomp | related,of |
R800 | T990 | T984 | cc | and,represents |
R801 | T991 | T992 | advmod | evolutionarily,conserved |
R802 | T992 | T993 | amod | conserved,proteins |
R803 | T993 | T984 | conj | proteins,represents |
R804 | T994 | T993 | punct | (,proteins |
R805 | T995 | T1010 | nmod | p100,) |
R806 | T996 | T995 | cc | or,p100 |
R807 | T997 | T995 | conj | NF-κB2,p100 |
R808 | T998 | T997 | punct | ",",NF-κB2 |
R809 | T999 | T997 | conj | p105,NF-κB2 |
R810 | T1000 | T999 | cc | or,p105 |
R811 | T1001 | T999 | conj | NF-κB1,p105 |
R812 | T1002 | T1001 | punct | ",",NF-κB1 |
R813 | T1003 | T1001 | conj | p65,NF-κB1 |
R814 | T1004 | T1003 | cc | or,p65 |
R815 | T1005 | T1003 | conj | RelA,p65 |
R816 | T1006 | T1005 | punct | ",",RelA |
R817 | T1007 | T1005 | conj | RelB,RelA |
R818 | T1008 | T1007 | punct | ",",RelB |
R819 | T1009 | T1007 | conj | c-Rel,RelB |
R820 | T1010 | T993 | punct | ),proteins |
R821 | T1011 | T1012 | nsubj | that,function |
R822 | T1012 | T993 | relcl | function,proteins |
R823 | T1013 | T1012 | prep | as,function |
R824 | T1014 | T1013 | pobj | homodimers,as |
R825 | T1015 | T1014 | cc | or,homodimers |
R826 | T1016 | T1014 | conj | heterodimers,homodimers |
R827 | T1017 | T1019 | nmod | [,] |
R828 | T1018 | T1019 | nummod | 1,] |
R829 | T1019 | T993 | conj | ],proteins |
R830 | T1020 | T1019 | punct | ",",] |
R831 | T1021 | T984 | cc | and,represents |
R832 | T1022 | T1023 | mark | that,regulate |
R833 | T1023 | T984 | conj | regulate,represents |
R834 | T1024 | T1025 | det | the,expression |
R835 | T1025 | T1023 | dobj | expression,regulate |
R836 | T1026 | T1025 | prep | of,expression |
R837 | T1027 | T1029 | det | a,number |
R838 | T1028 | T1029 | amod | large,number |
R839 | T1029 | T1026 | pobj | number,of |
R840 | T1030 | T1029 | prep | of,number |
R841 | T1031 | T1030 | pobj | genes,of |
R842 | T1032 | T1031 | punct | -,genes |
R843 | T1033 | T1034 | amod | such,as |
R844 | T1034 | T1031 | prep | as,genes |
R845 | T1035 | T1034 | pobj | TNF,as |
R846 | T1036 | T1035 | punct | ",",TNF |
R847 | T1037 | T1035 | conj | IL-1,TNF |
R848 | T1038 | T1037 | punct | ",",IL-1 |
R849 | T1039 | T1037 | conj | IL-6,IL-1 |
R850 | T1040 | T1039 | punct | ",",IL-6 |
R851 | T1041 | T1039 | conj | cyclo-oxygenase-2,IL-6 |
R852 | T1042 | T1041 | punct | ",",cyclo-oxygenase-2 |
R853 | T1043 | T1041 | conj | chemokines,cyclo-oxygenase-2 |
R854 | T1044 | T1043 | punct | ",",chemokines |
R855 | T1045 | T1048 | amod | inducible,synthase |
R856 | T1046 | T1047 | amod | nitric,oxide |
R857 | T1047 | T1048 | compound | oxide,synthase |
R858 | T1048 | T1043 | conj | synthase,chemokines |
R859 | T1049 | T1048 | punct | ",",synthase |
R860 | T1050 | T1048 | cc | and,synthase |
R861 | T1051 | T1052 | compound | matrix,metalloproteinases |
R862 | T1052 | T1048 | conj | metalloproteinases,synthase |
R863 | T1053 | T1056 | punct | -,involved |
R864 | T1054 | T1056 | nsubjpass | that,involved |
R865 | T1055 | T1056 | auxpass | are,involved |
R866 | T1056 | T1025 | relcl | involved,expression |
R867 | T1057 | T1056 | prep | in,involved |
R868 | T1058 | T1057 | pobj | RA,in |
R869 | T1059 | T984 | punct | .,represents |
R870 | T1060 | T1066 | prep | In,are |
R871 | T1061 | T1060 | pobj | addition,In |
R872 | T1062 | T1066 | punct | ",",are |
R873 | T1063 | T1066 | nsubj | TNF,are |
R874 | T1064 | T1063 | cc | and,TNF |
R875 | T1065 | T1063 | conj | IL-1,TNF |
R876 | T1066 | T1066 | ROOT | are,are |
R877 | T1067 | T1066 | nsubj | themselves,are |
R878 | T1068 | T1069 | advmod | very,potent |
R879 | T1069 | T1070 | amod | potent,activators |
R880 | T1070 | T1066 | attr | activators,are |
R881 | T1071 | T1070 | prep | of,activators |
R882 | T1072 | T1071 | pobj | NF-κB,of |
R883 | T1073 | T1072 | punct | (,NF-κB |
R884 | T1074 | T1072 | acl | reviewed,NF-κB |
R885 | T1075 | T1074 | prep | in,reviewed |
R886 | T1076 | T1075 | pobj | [,in |
R887 | T1077 | T1078 | nummod | "2,3",] |
R888 | T1078 | T1076 | appos | ],[ |
R889 | T1079 | T1076 | punct | ),[ |
R890 | T1080 | T1066 | punct | .,are |
R891 | T1081 | T1082 | amod | NF-κB,activation |
R892 | T1082 | T1085 | nsubjpass | activation,detected |
R893 | T1083 | T1085 | aux | can,detected |
R894 | T1084 | T1085 | auxpass | be,detected |
R895 | T1085 | T1104 | ccomp | detected,demonstrate |
R896 | T1086 | T1085 | prep | in,detected |
R897 | T1087 | T1089 | amod | cultured,fibroblasts |
R898 | T1088 | T1089 | amod | synovial,fibroblasts |
R899 | T1089 | T1086 | pobj | fibroblasts,in |
R900 | T1090 | T1089 | cc | and,fibroblasts |
R901 | T1091 | T1092 | amod | synovial,tissue |
R902 | T1092 | T1089 | conj | tissue,fibroblasts |
R903 | T1093 | T1092 | prep | from,tissue |
R904 | T1094 | T1095 | compound | RA,patients |
R905 | T1095 | T1093 | pobj | patients,from |
R906 | T1096 | T1092 | punct | ",",tissue |
R907 | T1097 | T1092 | cc | and,tissue |
R908 | T1098 | T1099 | compound | animal,models |
R909 | T1099 | T1104 | nsubj | models,demonstrate |
R910 | T1100 | T1099 | prep | of,models |
R911 | T1101 | T1102 | amod | inflammatory,arthritis |
R912 | T1102 | T1100 | pobj | arthritis,of |
R913 | T1103 | T1104 | advmod | also,demonstrate |
R914 | T1104 | T1104 | ROOT | demonstrate,demonstrate |
R915 | T1105 | T1107 | det | the,role |
R916 | T1106 | T1107 | amod | active,role |
R917 | T1107 | T1104 | dobj | role,demonstrate |
R918 | T1108 | T1107 | prep | of,role |
R919 | T1109 | T1108 | pobj | NF-κB,of |
R920 | T1110 | T1107 | prep | in,role |
R921 | T1111 | T1112 | det | the,development |
R922 | T1112 | T1110 | pobj | development,in |
R923 | T1113 | T1112 | cc | and,development |
R924 | T1114 | T1112 | conj | progression,development |
R925 | T1115 | T1112 | prep | of,development |
R926 | T1116 | T1115 | pobj | RA,of |
R927 | T1117 | T1107 | punct | (,role |
R928 | T1118 | T1107 | acl | reviewed,role |
R929 | T1119 | T1118 | prep | in,reviewed |
R930 | T1120 | T1119 | pobj | [,in |
R931 | T1121 | T1122 | nummod | 4,] |
R932 | T1122 | T1120 | appos | ],[ |
R933 | T1123 | T1120 | punct | ),[ |
R934 | T1124 | T1104 | punct | .,demonstrate |
R935 | T1125 | T1127 | det | The,course |
R936 | T1126 | T1127 | compound | time,course |
R937 | T1127 | T1131 | nsubj | course,appears |
R938 | T1128 | T1127 | prep | of,course |
R939 | T1129 | T1130 | amod | NF-κB,activation |
R940 | T1130 | T1128 | pobj | activation,of |
R941 | T1131 | T1131 | ROOT | appears,appears |
R942 | T1132 | T1133 | aux | to,precede |
R943 | T1133 | T1131 | xcomp | precede,appears |
R944 | T1134 | T1135 | det | the,onset |
R945 | T1135 | T1133 | dobj | onset,precede |
R946 | T1136 | T1135 | prep | of,onset |
R947 | T1137 | T1136 | pobj | disease,of |
R948 | T1138 | T1135 | punct | ",",onset |
R949 | T1139 | T1135 | cc | and,onset |
R950 | T1140 | T1135 | conj | blockade,onset |
R951 | T1141 | T1135 | prep | of,onset |
R952 | T1142 | T1141 | pobj | NF-κB,of |
R953 | T1143 | T1133 | prep | by,precede |
R954 | T1144 | T1145 | amod | different,means |
R955 | T1145 | T1143 | pobj | means,by |
R956 | T1146 | T1131 | conj | decreases,appears |
R957 | T1147 | T1148 | compound | disease,severity |
R958 | T1148 | T1146 | dobj | severity,decreases |
R959 | T1149 | T1151 | compound | [,] |
R960 | T1150 | T1151 | compound | "5,6",] |
R961 | T1151 | T1151 | ROOT | ],] |
R962 | T1152 | T1131 | punct | .,appears |
R963 | T1153 | T1163 | advmod | Next,is |
R964 | T1154 | T1153 | prep | to,Next |
R965 | T1155 | T1156 | poss | its,role |
R966 | T1156 | T1154 | pobj | role,to |
R967 | T1157 | T1156 | prep | in,role |
R968 | T1158 | T1160 | amod | proinflammatory,expression |
R969 | T1159 | T1160 | compound | gene,expression |
R970 | T1160 | T1157 | pobj | expression,in |
R971 | T1161 | T1163 | punct | ",",is |
R972 | T1162 | T1163 | nsubj | NF-κB,is |
R973 | T1163 | T1163 | ROOT | is,is |
R974 | T1164 | T1163 | advmod | also,is |
R975 | T1165 | T1163 | acomp | essential,is |
R976 | T1166 | T1165 | prep | for,essential |
R977 | T1167 | T1166 | pobj | osteoclastogenesis,for |
R978 | T1168 | T1166 | punct | ",",for |
R979 | T1169 | T1170 | advmod | mainly,by |
R980 | T1170 | T1163 | prep | by,is |
R981 | T1171 | T1170 | pcomp | mediating,by |
R982 | T1172 | T1173 | det | the,effects |
R983 | T1173 | T1171 | dobj | effects,mediating |
R984 | T1174 | T1173 | prep | of,effects |
R985 | T1175 | T1176 | compound | receptor,activator |
R986 | T1176 | T1174 | pobj | activator,of |
R987 | T1177 | T1176 | prep | of,activator |
R988 | T1178 | T1179 | amod | NF-κB,ligand |
R989 | T1179 | T1177 | pobj | ligand,of |
R990 | T1180 | T1181 | punct | (,RANKL |
R991 | T1222 | T1221 | punct | ",",signalling |
R992 | T1181 | T1179 | appos | RANKL,ligand |
R993 | T1223 | T1221 | prep | including,signalling |
R994 | T1224 | T1223 | pobj | CD40,including |
R995 | T1182 | T1163 | punct | ),is |
R996 | T1183 | T1163 | punct | .,is |
R997 | T1225 | T1224 | punct | ",",CD40 |
R998 | T1184 | T1190 | nsubj | Defects,are |
R999 | T1226 | T1224 | appos | TRAF1,CD40 |
R1000 | T1185 | T1184 | prep | in,Defects |
R1001 | T1227 | T1224 | punct | ",",CD40 |
R1002 | T1228 | T1224 | appos | TNFAIP3,CD40 |
R1003 | T1229 | T1224 | punct | ",",CD40 |
R1004 | T1186 | T1187 | det | the,regulation |
R1005 | T1230 | T1224 | cc | and,CD40 |
R1006 | T1231 | T1224 | conj | c-REL,CD40 |
R1007 | T1232 | T1231 | punct | ",",c-REL |
R1008 | T1187 | T1185 | pobj | regulation,in |
R1009 | T1233 | T1234 | advmod | further,highlight |
R1010 | T1234 | T1221 | appos | highlight,signalling |
R1011 | T1188 | T1187 | prep | of,regulation |
R1012 | T1235 | T1236 | det | the,importance |
R1013 | T1236 | T1234 | dobj | importance,highlight |
R1014 | T1237 | T1236 | prep | of,importance |
R1015 | T1238 | T1239 | amod | NF-κB,activation |
R1016 | T1239 | T1237 | pobj | activation,of |
R1017 | T1240 | T1239 | prep | in,activation |
R1018 | T1189 | T1188 | pobj | osteoclastogenesis,of |
R1019 | T1241 | T1243 | nmod | RA,[ |
R1020 | T1242 | T1243 | compound | pathogenesis,[ |
R1021 | T1243 | T1240 | pobj | [,in |
R1022 | T1190 | T1190 | ROOT | are,are |
R1023 | T1244 | T1245 | nummod | 8,] |
R1024 | T1245 | T1243 | appos | ],[ |
R1025 | T1246 | T1207 | punct | .,Finally |
R1026 | T1191 | T1193 | det | the,cause |
R1027 | T1192 | T1193 | amod | major,cause |
R1028 | T1193 | T1190 | attr | cause,are |
R1029 | T1194 | T1193 | prep | of,cause |
R1030 | T1195 | T1196 | compound | bone,erosion |
R1031 | T1196 | T1194 | pobj | erosion,of |
R1032 | T1197 | T1196 | prep | in,erosion |
R1033 | T1198 | T1199 | amod | osteolytic,diseases |
R1034 | T1199 | T1197 | pobj | diseases,in |
R1035 | T1200 | T1201 | amod | such,as |
R1036 | T1201 | T1199 | prep | as,diseases |
R1037 | T1202 | T1203 | compound | RA,[ |
R1038 | T1203 | T1201 | pobj | [,as |
R1039 | T1204 | T1205 | nummod | 7,] |
R1040 | T1205 | T1203 | conj | ],[ |
R1041 | T1206 | T1190 | punct | .,are |
R1042 | T1207 | T1207 | ROOT | Finally,Finally |
R1043 | T1208 | T1210 | punct | ",",discoveries |
R1044 | T1209 | T1210 | amod | recent,discoveries |
R1045 | T1210 | T1207 | pobj | discoveries,Finally |
R1046 | T1211 | T1210 | acl | revealing,discoveries |
R1047 | T1212 | T1214 | det | a,association |
R1048 | T1213 | T1214 | amod | genetic,association |
R1049 | T1214 | T1211 | dobj | association,revealing |
R1050 | T1215 | T1214 | prep | with,association |
R1051 | T1216 | T1217 | amod | several,genes |
R1052 | T1217 | T1215 | pobj | genes,with |
R1053 | T1218 | T1217 | amod | relevant,genes |
R1054 | T1219 | T1218 | prep | to,relevant |
R1055 | T1220 | T1221 | amod | NF-κB,signalling |
R1056 | T1221 | T1219 | pobj | signalling,to |
R1987 | T2608 | T2610 | mark | Since,is |
R1988 | T2609 | T2610 | nsubj | NF-κB,is |
R1989 | T2610 | T2622 | advcl | is,deals |
R1990 | T2611 | T2610 | acomp | central,is |
R1991 | T2612 | T2611 | prep | to,central |
R1992 | T2613 | T2614 | det | the,process |
R1993 | T2614 | T2612 | pobj | process,to |
R1994 | T2615 | T2614 | prep | of,process |
R1995 | T2616 | T2615 | pobj | inflammation,of |
R1996 | T2617 | T2614 | prep | in,process |
R1997 | T2618 | T2617 | pobj | RA,in |
R1998 | T2619 | T2622 | punct | ",",deals |
R1999 | T2620 | T2622 | amod | much,deals |
R2000 | T2621 | T2622 | compound | research,deals |
R2001 | T2622 | T2622 | ROOT | deals,deals |
R2002 | T2623 | T2622 | prep | with,deals |
R2003 | T2624 | T2625 | det | the,identification |
R2004 | T2625 | T2623 | pobj | identification,with |
R2005 | T2626 | T2625 | prep | of,identification |
R2006 | T2627 | T2628 | det | the,molecular |
R2007 | T2628 | T2626 | pobj | molecular,of |
R2008 | T2629 | T2622 | conj | triggers,deals |
R2009 | T2630 | T2631 | nsubj | that,activate |
R2010 | T2631 | T2629 | ccomp | activate,triggers |
R2011 | T2632 | T2631 | dobj | NF-κB,activate |
R2012 | T2633 | T2631 | prep | in,activate |
R2013 | T2634 | T2633 | pobj | RA,in |
R2014 | T2635 | T2629 | punct | .,triggers |
R2015 | T2636 | T2639 | nsubjpass | It,accepted |
R2016 | T2637 | T2639 | auxpass | is,accepted |
R2017 | T2638 | T2639 | advmod | well,accepted |
R2018 | T2639 | T2639 | ROOT | accepted,accepted |
R2019 | T2640 | T2648 | mark | that,play |
R2020 | T2641 | T2642 | amod | proinflammatory,cytokines |
R2021 | T2642 | T2648 | nsubj | cytokines,play |
R2022 | T2643 | T2644 | amod | such,as |
R2023 | T2644 | T2642 | prep | as,cytokines |
R2024 | T2645 | T2644 | pobj | TNF,as |
R2025 | T2646 | T2645 | cc | and,TNF |
R2026 | T2647 | T2645 | conj | IL-1,TNF |
R2027 | T2648 | T2639 | ccomp | play,accepted |
R2028 | T2649 | T2651 | det | an,role |
R2029 | T2650 | T2651 | amod | important,role |
R2030 | T2651 | T2648 | dobj | role,play |
R2031 | T2652 | T2648 | punct | ",",play |
R2032 | T2653 | T2648 | cc | and,play |
R2033 | T2654 | T2648 | conj | administration,play |
R2034 | T2655 | T2654 | prep | of,administration |
R2035 | T2656 | T2657 | compound | TNF,antagonists |
R2036 | T2657 | T2655 | pobj | antagonists,of |
R2037 | T2658 | T2639 | conj | is,accepted |
R2038 | T2659 | T2661 | det | an,treatment |
R2039 | T2660 | T2661 | amod | effective,treatment |
R2040 | T2661 | T2658 | attr | treatment,is |
R2041 | T2662 | T2661 | prep | for,treatment |
R2042 | T2663 | T2664 | amod | severe,RA |
R2043 | T2664 | T2662 | pobj | RA,for |
R2044 | T2665 | T2666 | punct | (,reviewed |
R2045 | T2666 | T2664 | parataxis | reviewed,RA |
R2046 | T2667 | T2666 | prep | in,reviewed |
R2047 | T2668 | T2667 | pobj | [,in |
R2048 | T2669 | T2670 | nummod | 9,] |
R2049 | T2670 | T2668 | appos | ],[ |
R2050 | T2671 | T2668 | punct | ),[ |
R2051 | T2672 | T2639 | punct | .,accepted |
R2052 | T2673 | T2676 | nsubj | TNF,are |
R2053 | T2674 | T2673 | cc | and,TNF |
R2054 | T2675 | T2673 | conj | IL-1,TNF |
R2055 | T2676 | T2676 | ROOT | are,are |
R2056 | T2677 | T2676 | dep | both,are |
R2057 | T2678 | T2679 | advmod | very,potent |
R2058 | T2679 | T2680 | amod | potent,activators |
R2059 | T2680 | T2676 | attr | activators,are |
R2060 | T2681 | T2680 | prep | of,activators |
R2061 | T2682 | T2681 | pobj | NF-κB,of |
R2062 | T2683 | T2676 | cc | and,are |
R2063 | T2684 | T2687 | nsubjpass | it,expected |
R2064 | T2685 | T2687 | aux | can,expected |
R2065 | T2686 | T2687 | auxpass | be,expected |
R2066 | T2687 | T2676 | conj | expected,are |
R2067 | T2688 | T2690 | det | that,activation |
R2068 | T2689 | T2690 | amod | NF-κB,activation |
R2069 | T2690 | T2694 | nsubj | activation,mediates |
R2070 | T2691 | T2690 | prep | by,activation |
R2071 | T2692 | T2693 | det | these,cytokines |
R2072 | T2693 | T2691 | pobj | cytokines,by |
R2073 | T2694 | T2676 | conj | mediates,are |
R2074 | T2695 | T2694 | dobj | most,mediates |
R2075 | T2696 | T2695 | prep | of,most |
R2076 | T2697 | T2699 | poss | their,activities |
R2077 | T2698 | T2699 | amod | pro-inflammatory,activities |
R2078 | T2699 | T2696 | pobj | activities,of |
R2079 | T2700 | T2699 | prep | in,activities |
R2080 | T2701 | T2700 | pobj | RA,in |
R2081 | T2702 | T2701 | punct | (,RA |
R2082 | T2703 | T2694 | advcl | reviewed,mediates |
R2083 | T2704 | T2703 | prep | in,reviewed |
R2084 | T2705 | T2704 | pobj | [,in |
R2085 | T2706 | T2707 | nummod | 3,] |
R2086 | T2707 | T2705 | appos | ],[ |
R2087 | T2708 | T2705 | punct | ),[ |
R2088 | T2709 | T2694 | punct | .,mediates |
R2089 | T2710 | T2711 | amod | NF-κB,activation |
R2090 | T2711 | T2727 | nsubj | activation,is |
R2091 | T2712 | T2711 | prep | by,activation |
R2092 | T2713 | T2712 | pobj | receptor,by |
R2093 | T2714 | T2711 | conj | activator,activation |
R2094 | T2715 | T2711 | prep | of,activation |
R2095 | T2716 | T2715 | pobj | NF-κB,of |
R2096 | T2717 | T2716 | punct | (,NF-κB |
R2097 | T2718 | T2716 | appos | RANK,NF-κB |
R2098 | T2719 | T2716 | punct | ),NF-κB |
R2099 | T2720 | T2716 | punct | ",",NF-κB |
R2100 | T2721 | T2725 | det | a,member |
R2101 | T2722 | T2725 | compound | TNF,member |
R2102 | T2723 | T2725 | compound | receptor,member |
R2103 | T2724 | T2725 | compound | family,member |
R2104 | T2725 | T2716 | appos | member,NF-κB |
R2105 | T2726 | T2727 | punct | ",",is |
R2106 | T2727 | T2727 | ROOT | is,is |
R2107 | T2728 | T2727 | acomp | important,is |
R2108 | T2729 | T2728 | prep | for,important |
R2109 | T2730 | T2729 | pobj | osteoclastogenesis,for |
R2110 | T2731 | T2729 | punct | ",",for |
R2111 | T2732 | T2728 | cc | and,important |
R2112 | T2733 | T2728 | conj | defects,important |
R2113 | T2734 | T2727 | prep | in,is |
R2114 | T2735 | T2736 | amod | proper,RANK-NF-κB |
R2115 | T2736 | T2734 | pobj | RANK-NF-κB,in |
R2116 | T2737 | T2738 | nsubj | signalling,are |
R2117 | T2738 | T2727 | conj | are,is |
R2118 | T2739 | T2738 | acomp | likely,are |
R2119 | T2740 | T2742 | aux | to,involved |
R2120 | T2741 | T2742 | auxpass | be,involved |
R2121 | T2742 | T2739 | xcomp | involved,likely |
R2122 | T2743 | T2742 | prep | in,involved |
R2123 | T2744 | T2745 | compound | RA,pathology |
R2124 | T2745 | T2743 | pobj | pathology,in |
R2125 | T2746 | T2745 | cc | and,pathology |
R2126 | T2747 | T2748 | amod | other,diseases |
R2127 | T2748 | T2745 | conj | diseases,pathology |
R2128 | T2749 | T2748 | acl | associated,diseases |
R2129 | T2750 | T2749 | prep | with,associated |
R2130 | T2751 | T2752 | compound | bone,loss |
R2131 | T2752 | T2753 | compound | loss,[ |
R2132 | T2753 | T2755 | compound | [,] |
R2133 | T2754 | T2755 | nummod | 7,] |
R2134 | T2755 | T2750 | pobj | ],with |
R2135 | T2756 | T2738 | punct | .,are |
R2136 | T2757 | T2758 | nsubj | CD40,is |
R2137 | T2758 | T2758 | ROOT | is,is |
R2138 | T2759 | T2763 | det | another,member |
R2139 | T2760 | T2763 | compound | TNF,member |
R2140 | T2761 | T2763 | compound | receptor,member |
R2141 | T2762 | T2763 | compound | family,member |
R2142 | T2763 | T2758 | attr | member,is |
R2143 | T2764 | T2767 | nsubjpass | that,expressed |
R2144 | T2765 | T2767 | auxpass | is,expressed |
R2145 | T2766 | T2767 | advmod | functionally,expressed |
R2146 | T2767 | T2763 | relcl | expressed,member |
R2147 | T2768 | T2767 | prep | on,expressed |
R2148 | T2769 | T2770 | det | a,variety |
R2149 | T2770 | T2768 | pobj | variety,on |
R2150 | T2771 | T2770 | prep | of,variety |
R2151 | T2772 | T2773 | compound | cell,types |
R2152 | T2773 | T2771 | pobj | types,of |
R2153 | T2774 | T2770 | punct | ",",variety |
R2154 | T2775 | T2770 | prep | including,variety |
R2155 | T2776 | T2777 | amod | smooth,muscle |
R2156 | T2777 | T2778 | compound | muscle,fibroblasts |
R2157 | T2778 | T2775 | pobj | fibroblasts,including |
R2158 | T2779 | T2778 | prep | from,fibroblasts |
R2159 | T2780 | T2783 | amod | normal,patients |
R2160 | T2781 | T2780 | cc | and,normal |
R2161 | T2782 | T2783 | compound | RA,patients |
R2162 | T2783 | T2779 | pobj | patients,from |
R2163 | T2784 | T2778 | cc | and,fibroblasts |
R2164 | T2785 | T2787 | nmod | RA,cells |
R2165 | T2786 | T2787 | amod | synovial,cells |
R2166 | T2787 | T2778 | conj | cells,fibroblasts |
R2167 | T2788 | T2787 | punct | ",",cells |
R2168 | T2789 | T2790 | compound | B,cells |
R2169 | T2790 | T2787 | conj | cells,cells |
R2170 | T2791 | T2790 | punct | ",",cells |
R2171 | T2792 | T2790 | conj | macrophages,cells |
R2172 | T2793 | T2792 | punct | ",",macrophages |
R2173 | T2794 | T2792 | cc | and,macrophages |
R2174 | T2795 | T2796 | amod | dendritic,cells |
R2175 | T2796 | T2792 | conj | cells,macrophages |
R2176 | T2797 | T2758 | punct | ",",is |
R2177 | T2798 | T2758 | cc | and,is |
R2178 | T2799 | T2801 | aux | can,upregulated |
R2179 | T2800 | T2801 | auxpass | be,upregulated |
R2180 | T2801 | T2758 | conj | upregulated,is |
R2181 | T2802 | T2801 | agent | by,upregulated |
R2182 | T2803 | T2804 | amod | proinflammatory,cytokines |
R2183 | T2804 | T2802 | pobj | cytokines,by |
R2184 | T2805 | T2804 | prep | including,cytokines |
R2185 | T2806 | T2807 | compound | TNF,[ |
R2186 | T2807 | T2805 | pobj | [,including |
R2187 | T2808 | T2809 | nummod | 10,] |
R2188 | T2809 | T2807 | appos | ],[ |
R2189 | T2810 | T2758 | punct | .,is |
R2190 | T2811 | T2834 | advcl | Binding,triggers |
R2191 | T2812 | T2811 | prep | of,Binding |
R2192 | T2813 | T2815 | det | the,ligand |
R2193 | T2814 | T2815 | compound | CD40,ligand |
R2194 | T2815 | T2812 | pobj | ligand,of |
R2195 | T2816 | T2817 | punct | (,CD154 |
R2196 | T2817 | T2815 | appos | CD154,ligand |
R2197 | T2818 | T2817 | punct | ),CD154 |
R2198 | T2819 | T2815 | punct | ",",ligand |
R2199 | T2820 | T2823 | nsubjpass | which,expressed |
R2200 | T2821 | T2823 | auxpass | is,expressed |
R2201 | T2822 | T2823 | advmod | transiently,expressed |
R2202 | T2823 | T2815 | relcl | expressed,ligand |
R2203 | T2824 | T2823 | prep | on,expressed |
R2204 | T2825 | T2826 | det | the,surface |
R2205 | T2826 | T2824 | pobj | surface,on |
R2206 | T2827 | T2826 | prep | of,surface |
R2207 | T2828 | T2832 | amod | activated,cells |
R2208 | T2829 | T2832 | compound | CD4,cells |
R2209 | T2830 | T2832 | nummod | +,cells |
R2210 | T2831 | T2832 | compound | T,cells |
R2211 | T2832 | T2827 | pobj | cells,of |
R2212 | T2833 | T2834 | punct | ",",triggers |
R2213 | T2834 | T2834 | ROOT | triggers,triggers |
R2214 | T2835 | T2836 | compound | NF-κB,activation |
R2215 | T2836 | T2834 | dobj | activation,triggers |
R2216 | T2837 | T2836 | acl | resulting,activation |
R2217 | T2838 | T2837 | prep | in,resulting |
R2218 | T2839 | T2840 | compound | fibroblast,proliferation |
R2219 | T2840 | T2838 | pobj | proliferation,in |
R2220 | T2841 | T2840 | cc | and,proliferation |
R2221 | T2842 | T2840 | conj | secretion,proliferation |
R2222 | T2843 | T2842 | prep | of,secretion |
R2223 | T2844 | T2845 | amod | proinflammatory,cytokines |
R2224 | T2845 | T2843 | pobj | cytokines,of |
R2225 | T2846 | T2845 | cc | and,cytokines |
R2226 | T2847 | T2845 | conj | chemokines,cytokines |
R2227 | T2848 | T2845 | punct | ",",cytokines |
R2228 | T2849 | T2850 | nsubj | which,contributes |
R2229 | T2850 | T2840 | relcl | contributes,proliferation |
R2230 | T2851 | T2850 | prep | to,contributes |
R2231 | T2852 | T2853 | amod | joint,destruction |
R2232 | T2853 | T2851 | pobj | destruction,to |
R2233 | T2854 | T2834 | punct | .,triggers |
R2234 | T2855 | T2864 | advmod | However,led |
R2235 | T2856 | T2864 | punct | ",",led |
R2236 | T2857 | T2864 | nsubj | studies,led |
R2237 | T2858 | T2857 | prep | with,studies |
R2238 | T2859 | T2863 | amod | antagonistic,antibodies |
R2239 | T2860 | T2863 | amod | anti-CD40,antibodies |
R2240 | T2861 | T2860 | cc | or,anti-CD40 |
R2241 | T2862 | T2860 | conj | anti-CD154,anti-CD40 |
R2242 | T2863 | T2858 | pobj | antibodies,with |
R2243 | T2923 | T2918 | pobj | lymphocytes,of |
R2244 | T2864 | T2864 | ROOT | led,led |
R2245 | T2924 | T2925 | punct | ",",is |
R2246 | T2865 | T2864 | prep | to,led |
R2247 | T2925 | T2925 | ROOT | is,is |
R2248 | T2926 | T2925 | advmod | also,is |
R2249 | T2866 | T2867 | det | the,conclusion |
R2250 | T2927 | T2925 | acomp | characteristic,is |
R2251 | T2928 | T2927 | prep | for,characteristic |
R2252 | T2929 | T2928 | pobj | RA,for |
R2253 | T2867 | T2865 | pobj | conclusion,to |
R2254 | T2930 | T2925 | punct | ",",is |
R2255 | T2931 | T2925 | cc | and,is |
R2256 | T2932 | T2937 | nsubjpass | antagonists,developed |
R2257 | T2868 | T2872 | mark | that,be |
R2258 | T2933 | T2932 | prep | of,antagonists |
R2259 | T2934 | T2933 | pobj | BAFF,of |
R2260 | T2935 | T2937 | aux | have,developed |
R2261 | T2869 | T2870 | compound | CD40,signals |
R2262 | T2936 | T2937 | auxpass | been,developed |
R2263 | T2937 | T2925 | conj | developed,is |
R2264 | T2938 | T2939 | aux | to,counter |
R2265 | T2870 | T2872 | nsubj | signals,be |
R2266 | T2939 | T2937 | advcl | counter,developed |
R2267 | T2940 | T2941 | compound | RA,[ |
R2268 | T2941 | T2939 | dobj | [,counter |
R2269 | T2871 | T2872 | aux | may,be |
R2270 | T2942 | T2943 | nummod | 13,] |
R2271 | T2943 | T2941 | appos | ],[ |
R2272 | T2944 | T2925 | punct | .,is |
R2273 | T2872 | T2867 | acl | be,conclusion |
R2274 | T2945 | T2953 | advmod | Finally,implicated |
R2275 | T2946 | T2953 | punct | ",",implicated |
R2276 | T2947 | T2950 | amod | lymphotoxin,signalling |
R2277 | T2948 | T2949 | compound | β,receptor |
R2278 | T2949 | T2950 | compound | receptor,signalling |
R2279 | T2873 | T2872 | acomp | important,be |
R2280 | T2950 | T2953 | nsubjpass | signalling,implicated |
R2281 | T2951 | T2953 | aux | has,implicated |
R2282 | T2874 | T2872 | prep | at,be |
R2283 | T2952 | T2953 | auxpass | been,implicated |
R2284 | T2953 | T2953 | ROOT | implicated,implicated |
R2285 | T2954 | T2953 | prep | in,implicated |
R2286 | T2955 | T2958 | amod | tertiary,formation |
R2287 | T2875 | T2877 | det | the,stages |
R2288 | T2876 | T2877 | amod | initial,stages |
R2289 | T2956 | T2958 | amod | lymphoid,formation |
R2290 | T2877 | T2874 | pobj | stages,at |
R2291 | T2957 | T2958 | compound | organ,formation |
R2292 | T2958 | T2954 | pobj | formation,in |
R2293 | T2959 | T2958 | prep | at,formation |
R2294 | T2878 | T2877 | prep | of,stages |
R2295 | T2960 | T2959 | pobj | sites,at |
R2296 | T2961 | T2960 | prep | of,sites |
R2297 | T2962 | T2963 | amod | chronic,inflammation |
R2298 | T2879 | T2880 | compound | arthritis,induction |
R2299 | T2963 | T2961 | pobj | inflammation,of |
R2300 | T2964 | T2960 | prep | including,sites |
R2301 | T2965 | T2966 | compound | RA,[ |
R2302 | T2880 | T2878 | pobj | induction,of |
R2303 | T2966 | T2964 | pobj | [,including |
R2304 | T2967 | T2968 | nummod | 13,] |
R2305 | T2968 | T2966 | appos | ],[ |
R2306 | T2881 | T2864 | punct | ",",led |
R2307 | T2969 | T2953 | punct | .,implicated |
R2308 | T2970 | T2971 | amod | Toll-like,receptors |
R2309 | T2882 | T2864 | cc | but,led |
R2310 | T2971 | T2977 | nsubjpass | receptors,implicated |
R2311 | T2972 | T2971 | punct | (,receptors |
R2312 | T2973 | T2971 | appos | TLRs,receptors |
R2313 | T2974 | T2971 | punct | ),receptors |
R2314 | T2883 | T2885 | auxpass | are,required |
R2315 | T2975 | T2977 | aux | have,implicated |
R2316 | T2976 | T2977 | auxpass | been,implicated |
R2317 | T2977 | T2977 | ROOT | implicated,implicated |
R2318 | T2884 | T2885 | neg | not,required |
R2319 | T2978 | T2977 | prep | in,implicated |
R2320 | T2979 | T2980 | det | a,variety |
R2321 | T2885 | T2864 | conj | required,led |
R2322 | T2980 | T2978 | pobj | variety,in |
R2323 | T2981 | T2980 | prep | of,variety |
R2324 | T2982 | T2983 | amod | autoimmune,diseases |
R2325 | T2983 | T2981 | pobj | diseases,of |
R2326 | T2984 | T2977 | cc | and,implicated |
R2327 | T2985 | T2977 | conj | are,implicated |
R2328 | T2886 | T2889 | mark | once,established |
R2329 | T2986 | T2987 | amod | potential,candidates |
R2330 | T2987 | T2985 | attr | candidates,are |
R2331 | T2988 | T2987 | prep | for,candidates |
R2332 | T2989 | T2988 | pcomp | inducing,for |
R2333 | T2887 | T2889 | nsubjpass | disease,established |
R2334 | T2990 | T2991 | amod | NF-κB-dependent,inflammation |
R2335 | T2991 | T2989 | dobj | inflammation,inducing |
R2336 | T2888 | T2889 | auxpass | is,established |
R2337 | T2992 | T2991 | prep | in,inflammation |
R2338 | T2993 | T2992 | pobj | RA,in |
R2339 | T2994 | T2977 | punct | .,implicated |
R2340 | T2995 | T3021 | prep | In,reported |
R2341 | T2889 | T2885 | advcl | established,required |
R2342 | T2996 | T2995 | pobj | addition,In |
R2343 | T2997 | T2996 | prep | to,addition |
R2344 | T2998 | T2999 | amod | microbial,ligands |
R2345 | T2890 | T2889 | cc | and,established |
R2346 | T2999 | T2997 | pobj | ligands,to |
R2347 | T3000 | T2999 | punct | ",",ligands |
R2348 | T2891 | T2889 | conj | pathogenic,established |
R2349 | T3001 | T3003 | det | an,number |
R2350 | T3002 | T3003 | amod | increasing,number |
R2351 | T3003 | T2999 | appos | number,ligands |
R2352 | T2892 | T2893 | nsubj | antibodies,are |
R2353 | T3004 | T3003 | prep | of,number |
R2354 | T3005 | T3006 | amod | endogenous,ligands |
R2355 | T3006 | T3004 | pobj | ligands,of |
R2356 | T2893 | T2864 | conj | are,led |
R2357 | T3007 | T3006 | punct | -,ligands |
R2358 | T3008 | T3009 | det | a,group |
R2359 | T3009 | T3003 | conj | group,number |
R2360 | T2894 | T2893 | advmod | already,are |
R2361 | T3010 | T3009 | prep | of,group |
R2362 | T3011 | T3010 | pobj | proteins,of |
R2363 | T3012 | T3011 | acl | derived,proteins |
R2364 | T2895 | T2893 | acomp | present,are |
R2365 | T3013 | T3012 | prep | from,derived |
R2366 | T3014 | T3015 | compound | host,tissues |
R2367 | T3015 | T3013 | pobj | tissues,from |
R2368 | T2896 | T2898 | compound | [,] |
R2369 | T3016 | T3015 | cc | and,tissues |
R2370 | T3017 | T3015 | conj | cells,tissues |
R2371 | T3018 | T3021 | punct | -,reported |
R2372 | T2897 | T2898 | compound | "11,12",] |
R2373 | T3019 | T3021 | aux | have,reported |
R2374 | T2898 | T2893 | attr | ],are |
R2375 | T2899 | T2893 | punct | .,are |
R2376 | T3020 | T3021 | auxpass | been,reported |
R2377 | T3021 | T3021 | ROOT | reported,reported |
R2378 | T3022 | T3021 | prep | as,reported |
R2379 | T3023 | T3024 | compound | candidate,activators |
R2380 | T2900 | T2901 | amod | Enhanced,expression |
R2381 | T3024 | T3022 | pobj | activators,as |
R2382 | T3025 | T3024 | prep | of,activators |
R2383 | T3026 | T3025 | pobj | TLRs,of |
R2384 | T3027 | T3024 | acl | inducing,activators |
R2385 | T2901 | T2925 | nsubj | expression,is |
R2386 | T3028 | T3030 | amod | so-called,inflammation |
R2387 | T2902 | T2901 | prep | of,expression |
R2388 | T3029 | T3030 | amod | sterile,inflammation |
R2389 | T3030 | T3027 | dobj | inflammation,inducing |
R2390 | T3031 | T3030 | punct | (,inflammation |
R2391 | T2903 | T2907 | det | the,member |
R2392 | T3032 | T3030 | acl | reviewed,inflammation |
R2393 | T2904 | T2907 | compound | TNF,member |
R2394 | T3033 | T3032 | prep | in,reviewed |
R2395 | T2905 | T2907 | compound | receptor,member |
R2396 | T3034 | T3033 | pobj | [,in |
R2397 | T3035 | T3036 | nummod | "14,15",] |
R2398 | T2906 | T2907 | compound | family,member |
R2399 | T3036 | T3034 | appos | ],[ |
R2400 | T2907 | T2910 | nmod | member,factor |
R2401 | T3037 | T3034 | punct | ),[ |
R2402 | T2908 | T2910 | nmod | B-cell,factor |
R2403 | T3038 | T3021 | punct | .,reported |
R2404 | T3039 | T3041 | nsubjpass | TLRs,expressed |
R2405 | T3040 | T3041 | auxpass | are,expressed |
R2406 | T2909 | T2910 | amod | activating,factor |
R2407 | T3041 | T3041 | ROOT | expressed,expressed |
R2408 | T3042 | T3041 | prep | in,expressed |
R2409 | T3043 | T3045 | compound | RA,tissues |
R2410 | T2910 | T2902 | pobj | factor,of |
R2411 | T3044 | T3045 | compound | synovial,tissues |
R2412 | T3045 | T3042 | pobj | tissues,in |
R2413 | T2911 | T2912 | punct | (,BAFF |
R2414 | T3046 | T3045 | cc | and,tissues |
R2415 | T3047 | T3049 | amod | various,ligands |
R2416 | T3048 | T3049 | amod | endogenous,ligands |
R2417 | T2912 | T2910 | appos | BAFF,factor |
R2418 | T3049 | T3045 | conj | ligands,tissues |
R2419 | T3050 | T3041 | conj | are,expressed |
R2420 | T2913 | T2910 | punct | ),factor |
R2421 | T3051 | T3050 | acomp | present,are |
R2422 | T3052 | T3050 | prep | within,are |
R2423 | T3053 | T3055 | det | the,joints |
R2424 | T3054 | T3055 | amod | inflamed,joints |
R2425 | T2914 | T2901 | punct | ",",expression |
R2426 | T3055 | T3052 | pobj | joints,within |
R2427 | T3056 | T3055 | prep | of,joints |
R2428 | T3057 | T3058 | compound | RA,patients |
R2429 | T3058 | T3056 | pobj | patients,of |
R2430 | T3059 | T3041 | punct | .,expressed |
R2431 | T3060 | T3075 | advmod | Moreover,identify |
R2432 | T2915 | T2901 | acl | allowing,expression |
R2433 | T3061 | T3075 | punct | ",",identify |
R2434 | T3062 | T3063 | compound | animal,models |
R2435 | T3063 | T3075 | nsubj | models,identify |
R2436 | T2916 | T2917 | det | the,survival |
R2437 | T3064 | T3063 | acl | using,models |
R2438 | T3065 | T3067 | compound | TLR,mice |
R2439 | T3066 | T3067 | compound | knockout,mice |
R2440 | T2917 | T2915 | dobj | survival,allowing |
R2441 | T3067 | T3064 | dobj | mice,using |
R2442 | T3068 | T3067 | cc | or,mice |
R2443 | T3069 | T3067 | conj | strategies,mice |
R2444 | T2918 | T2917 | prep | of,survival |
R2445 | T3070 | T3071 | aux | to,block |
R2446 | T3071 | T3064 | xcomp | block,using |
R2447 | T3072 | T3071 | dobj | TLR,block |
R2448 | T3073 | T3064 | conj | signalling,using |
R2449 | T2919 | T2921 | npadvmod | autoantibody,producing |
R2450 | T3074 | T3075 | advmod | clearly,identify |
R2451 | T3075 | T3075 | ROOT | identify,identify |
R2452 | T3076 | T3077 | amod | TLR-dependent,inflammation |
R2453 | T2920 | T2921 | punct | -,producing |
R2454 | T3077 | T3075 | dobj | inflammation,identify |
R2455 | T3078 | T3075 | prep | as,identify |
R2456 | T3079 | T3078 | pcomp | being,as |
R2457 | T2921 | T2923 | amod | producing,lymphocytes |
R2458 | T3080 | T3079 | acomp | important,being |
R2459 | T3081 | T3079 | prep | in,being |
R2460 | T3082 | T3083 | det | the,pathogenesis |
R2461 | T2922 | T2923 | compound | B,lymphocytes |
R2462 | T3083 | T3081 | pobj | pathogenesis,in |
R2463 | T3084 | T3083 | prep | of,pathogenesis |
R2464 | T3085 | T3086 | det | the,disease |
R2465 | T3117 | T3093 | punct | ",",protein |
R2466 | T3086 | T3084 | pobj | disease,of |
R2467 | T3087 | T3075 | punct | .,identify |
R2468 | T3088 | T3091 | amod | High,box |
R2469 | T3118 | T3118 | ROOT | is,is |
R2470 | T3089 | T3091 | compound | mobility,box |
R2471 | T3090 | T3091 | compound | group,box |
R2472 | T3091 | T3093 | compound | box,protein |
R2473 | T3092 | T3093 | compound | chromosomal,protein |
R2474 | T3119 | T3118 | attr | one,is |
R2475 | T3093 | T3118 | nsubj | protein,is |
R2476 | T3094 | T3093 | nummod | 1,protein |
R2477 | T3095 | T3093 | punct | (,protein |
R2478 | T3096 | T3093 | appos | HMGB1,protein |
R2479 | T3097 | T3093 | punct | ),protein |
R2480 | T3098 | T3093 | punct | ",",protein |
R2481 | T3120 | T3119 | prep | of,one |
R2482 | T3099 | T3103 | det | a,component |
R2483 | T3100 | T3101 | advmod | highly,conserved |
R2484 | T3101 | T3103 | amod | conserved,component |
R2485 | T3102 | T3103 | compound | chromatin,component |
R2486 | T3121 | T3126 | det | the,ligands |
R2487 | T3103 | T3093 | appos | component,protein |
R2488 | T3104 | T3108 | nsubjpass | that,secreted |
R2489 | T3122 | T3123 | advmod | most,putative |
R2490 | T3105 | T3108 | aux | can,secreted |
R2491 | T3106 | T3108 | auxpass | be,secreted |
R2492 | T3107 | T3108 | advmod | actively,secreted |
R2493 | T3123 | T3126 | amod | putative,ligands |
R2494 | T3108 | T3103 | relcl | secreted,component |
R2495 | T3109 | T3108 | agent | by,secreted |
R2496 | T3110 | T3109 | pobj | macrophages,by |
R2497 | T3124 | T3126 | amod | endogenous,ligands |
R2498 | T3111 | T3110 | cc | or,macrophages |
R2499 | T3112 | T3113 | advmod | passively,released |
R2500 | T3113 | T3110 | acl | released,macrophages |
R2501 | T3125 | T3126 | nummod | TLR4,ligands |
R2502 | T3114 | T3113 | agent | by,released |
R2503 | T3126 | T3120 | pobj | ligands,of |
R2504 | T3127 | T3126 | acl | involved,ligands |
R2505 | T3115 | T3116 | amod | necrotic,cells |
R2506 | T3116 | T3114 | pobj | cells,by |
R2507 | T3128 | T3127 | prep | in,involved |
R2508 | T3129 | T3130 | compound | RA,pathology |
R2509 | T3130 | T3128 | pobj | pathology,in |
R2510 | T3131 | T3118 | punct | .,is |
R2511 | T3132 | T3134 | nsubjpass | HMGB1,increased |
R2512 | T3214 | T3210 | relcl | involved,ligands |
R2513 | T3215 | T3214 | prep | in,involved |
R2514 | T3133 | T3134 | auxpass | is,increased |
R2515 | T3216 | T3217 | compound | RA,pathology |
R2516 | T3217 | T3215 | pobj | pathology,in |
R2517 | T3218 | T3218 | ROOT | are,are |
R2518 | T3134 | T3134 | ROOT | increased,increased |
R2519 | T3219 | T3221 | amod | extracellular,components |
R2520 | T3220 | T3221 | compound | matrix,components |
R2521 | T3135 | T3134 | prep | in,increased |
R2522 | T3221 | T3218 | attr | components,are |
R2523 | T3222 | T3223 | amod | such,as |
R2524 | T3223 | T3221 | prep | as,components |
R2525 | T3136 | T3138 | nmod | RA,tissue |
R2526 | T3224 | T3223 | pobj | fibrinogen,as |
R2527 | T3225 | T3224 | punct | ",",fibrinogen |
R2528 | T3137 | T3138 | amod | synovial,tissue |
R2529 | T3226 | T3224 | conj | fibronectin,fibrinogen |
R2530 | T3227 | T3226 | punct | ",",fibronectin |
R2531 | T3228 | T3226 | conj | biglycan,fibronectin |
R2532 | T3138 | T3135 | pobj | tissue,in |
R2533 | T3229 | T3228 | punct | ",",biglycan |
R2534 | T3230 | T3231 | compound | tenascin,C |
R2535 | T3231 | T3228 | conj | C,biglycan |
R2536 | T3139 | T3138 | cc | and,tissue |
R2537 | T3232 | T3231 | punct | ",",C |
R2538 | T3233 | T3231 | cc | and,C |
R2539 | T3234 | T3236 | amod | hyal-uronic,fragments |
R2540 | T3140 | T3141 | nsubj | HMGB1,neutralising |
R2541 | T3235 | T3236 | compound | acid,fragments |
R2542 | T3236 | T3231 | conj | fragments,C |
R2543 | T3237 | T3236 | punct | (,fragments |
R2544 | T3141 | T3138 | conj | neutralising,tissue |
R2545 | T3238 | T3236 | acl | reviewed,fragments |
R2546 | T3239 | T3238 | prep | in,reviewed |
R2547 | T3142 | T3141 | dobj | antibodies,neutralising |
R2548 | T3240 | T3239 | pobj | [,in |
R2549 | T3241 | T3242 | nummod | "14,15",] |
R2550 | T3143 | T3142 | cc | or,antibodies |
R2551 | T3242 | T3240 | appos | ],[ |
R2552 | T3243 | T3240 | punct | ),[ |
R2553 | T3244 | T3218 | punct | .,are |
R2554 | T3144 | T3147 | det | the,domain |
R2555 | T3245 | T3249 | advmod | Together,suggest |
R2556 | T3246 | T3249 | punct | ",",suggest |
R2557 | T3247 | T3248 | det | these,studies |
R2558 | T3145 | T3147 | amod | antagonistic,domain |
R2559 | T3248 | T3249 | nsubj | studies,suggest |
R2560 | T3249 | T3249 | ROOT | suggest,suggest |
R2561 | T3250 | T3260 | mark | that,contribute |
R2562 | T3146 | T3147 | compound | BoxA,domain |
R2563 | T3251 | T3253 | amod | several,ligands |
R2564 | T3252 | T3253 | compound | TLR,ligands |
R2565 | T3253 | T3260 | nsubj | ligands,contribute |
R2566 | T3147 | T3142 | conj | domain,antibodies |
R2567 | T3254 | T3253 | prep | in,ligands |
R2568 | T3255 | T3258 | det | the,tissue |
R2569 | T3256 | T3258 | amod | inflamed,tissue |
R2570 | T3148 | T3147 | prep | of,domain |
R2571 | T3257 | T3258 | amod | joint,tissue |
R2572 | T3258 | T3254 | pobj | tissue,in |
R2573 | T3259 | T3260 | aux | may,contribute |
R2574 | T3149 | T3148 | pobj | HMGB1,of |
R2575 | T3260 | T3249 | ccomp | contribute,suggest |
R2576 | T3261 | T3260 | prep | to,contribute |
R2577 | T3262 | T3263 | amod | NF-κB,activation |
R2578 | T3263 | T3261 | pobj | activation,to |
R2579 | T3264 | T3263 | cc | and,activation |
R2580 | T3265 | T3267 | amod | inflammatory,expression |
R2581 | T3150 | T3134 | conj | protect,increased |
R2582 | T3266 | T3267 | compound | gene,expression |
R2583 | T3267 | T3263 | conj | expression,activation |
R2584 | T3268 | T3263 | prep | in,activation |
R2585 | T3151 | T3150 | prep | against,protect |
R2586 | T3269 | T3268 | pobj | RA,in |
R2587 | T3270 | T3249 | punct | .,suggest |
R2588 | T3152 | T3153 | amod | collagen-induced,arthritis |
R2589 | T3153 | T3151 | pobj | arthritis,against |
R2590 | T3154 | T3153 | prep | in,arthritis |
R2591 | T3155 | T3154 | pobj | mice,in |
R2592 | T3156 | T3158 | nmod | [,] |
R2593 | T3157 | T3158 | nummod | 16,] |
R2594 | T3158 | T3158 | ROOT | ],] |
R2595 | T3159 | T3134 | punct | .,increased |
R2596 | T3160 | T3161 | amod | Myeloid-related,protein |
R2597 | T3161 | T3181 | nsubj | protein,are |
R2598 | T3162 | T3161 | nummod | 8,protein |
R2599 | T3163 | T3161 | cc | and,protein |
R2600 | T3164 | T3165 | amod | myeloid-related,protein |
R2601 | T3165 | T3161 | conj | protein,protein |
R2602 | T3166 | T3165 | nummod | 14,protein |
R2603 | T3167 | T3165 | punct | ",",protein |
R2604 | T3168 | T3171 | amod | damage-associated,molecules |
R2605 | T3169 | T3170 | amod | molecular,pattern |
R2606 | T3170 | T3171 | compound | pattern,molecules |
R2607 | T3171 | T3165 | conj | molecules,protein |
R2608 | T3172 | T3171 | acl | belonging,molecules |
R2609 | T3173 | T3172 | prep | to,belonging |
R2610 | T3174 | T3176 | det | the,family |
R2611 | T3175 | T3176 | compound | S100,family |
R2615 | T3176 | T3173 | pobj | family,to |
R2620 | T3177 | T3176 | prep | of,family |
R2622 | T3178 | T3179 | amod | calcium-binding,proteins |
R2624 | T3179 | T3177 | pobj | proteins,of |
R2625 | T3180 | T3181 | punct | ",",are |
R2626 | T3181 | T3181 | ROOT | are,are |
R2631 | T3182 | T3181 | advmod | also,are |
R2632 | T3183 | T3184 | advmod | abundantly,present |
R2634 | T3184 | T3181 | acomp | present,are |
R2635 | T3185 | T3184 | prep | in,present |
R2636 | T3186 | T3188 | nmod | RA,fluid |
R2639 | T3187 | T3188 | compound | synovial,fluid |
R2640 | T3188 | T3185 | pobj | fluid,in |
R2641 | T3189 | T3181 | punct | ",",are |
R2642 | T3190 | T3181 | cc | and,are |
R2643 | T3191 | T3193 | aux | have,suggested |
R2644 | T3192 | T3193 | auxpass | been,suggested |
R2645 | T3193 | T3181 | conj | suggested,are |
R2646 | T3194 | T3196 | aux | to,involved |
R2647 | T3195 | T3196 | auxpass | be,involved |
R2649 | T3196 | T3193 | xcomp | involved,suggested |
R2650 | T3197 | T3196 | prep | in,involved |
R2651 | T3198 | T3200 | amod | TLR4-induced,inflammation |
R2653 | T3199 | T3200 | amod | chronic,inflammation |
R2655 | T3200 | T3197 | pobj | inflammation,in |
R2657 | T3201 | T3200 | prep | in,inflammation |
R2659 | T3202 | T3203 | compound | RA,[ |
R2660 | T3203 | T3201 | pobj | [,in |
R2661 | T3204 | T3205 | nummod | "17,18",] |
R2665 | T3205 | T3193 | conj | ],suggested |
R2668 | T3206 | T3181 | punct | .,are |
R2669 | T3207 | T3210 | amod | Other,ligands |
R2674 | T3208 | T3210 | amod | endogenous,ligands |
R2677 | T3209 | T3210 | compound | TLR,ligands |
R2678 | T3210 | T3218 | nsubj | ligands,are |
R2679 | T3211 | T3214 | nsubjpass | that,involved |
R2680 | T3212 | T3214 | aux | may,involved |
R2681 | T3213 | T3214 | auxpass | be,involved |
R3980 | T5918 | T5920 | nsubjpass | proteins,sequestered |
R3981 | T5919 | T5920 | auxpass | are,sequestered |
R3982 | T5920 | T5920 | ROOT | sequestered,sequestered |
R3983 | T5921 | T5920 | prep | in,sequestered |
R3984 | T5922 | T5923 | det | the,cytoplasm |
R3985 | T5923 | T5921 | pobj | cytoplasm,in |
R3986 | T5924 | T5920 | prep | as,sequestered |
R3987 | T5925 | T5926 | amod | latent,complexes |
R3988 | T5926 | T5924 | pobj | complexes,as |
R3989 | T5927 | T5920 | agent | by,sequestered |
R3990 | T5928 | T5929 | amod | inhibitory,proteins |
R3991 | T5929 | T5927 | pobj | proteins,by |
R3992 | T5930 | T5920 | conj | referred,sequestered |
R3993 | T5931 | T5930 | prep | to,referred |
R3994 | T5932 | T5930 | prep | as,referred |
R3995 | T5933 | T5932 | pobj | inhibitor,as |
R3996 | T5934 | T5933 | prep | of,inhibitor |
R3997 | T5935 | T5934 | pobj | NF-κB,of |
R3998 | T5936 | T5935 | punct | (,NF-κB |
R3999 | T5937 | T5935 | appos | IκB,NF-κB |
R4001 | T5938 | T5935 | punct | ),NF-κB |
R4004 | T5939 | T5934 | pobj | proteins,of |
R4007 | T5962 | T5961 | punct | ",",IκBβ |
R4008 | T5940 | T5939 | punct | ",",proteins |
R4009 | T5963 | T5961 | conj | IκBε,IκBβ |
R4010 | T5964 | T5963 | punct | ",",IκBε |
R4011 | T5965 | T5963 | conj | p105,IκBε |
R4012 | T5941 | T5942 | nsubj | which,prevent |
R4013 | T5966 | T5965 | punct | (,p105 |
R4014 | T5967 | T5968 | advmod | also,known |
R4015 | T5968 | T5965 | acl | known,p105 |
R4016 | T5942 | T5939 | relcl | prevent,proteins |
R4017 | T5969 | T5968 | prep | as,known |
R4018 | T5970 | T5969 | pobj | NF-κB1,as |
R4019 | T5943 | T5945 | amod | NF-κB,translocation |
R4020 | T5944 | T5945 | amod | nuclear,translocation |
R4021 | T5945 | T5942 | dobj | translocation,prevent |
R4022 | T5971 | T5965 | punct | ),p105 |
R4023 | T5972 | T5959 | punct | ",",IκBα |
R4024 | T5946 | T5945 | cc | and,translocation |
R4025 | T5973 | T5957 | appos | p100,IκBs |
R4026 | T5974 | T5976 | punct | (,known |
R4027 | T5947 | T5948 | npadvmod | DNA,binding |
R4028 | T5975 | T5976 | advmod | also,known |
R4029 | T5976 | T5973 | acl | known,p100 |
R4030 | T5977 | T5976 | prep | as,known |
R4031 | T5948 | T5951 | amod | binding,] |
R4032 | T5978 | T5977 | pobj | NF-κB2,as |
R4033 | T5979 | T5973 | punct | ),p100 |
R4034 | T5949 | T5951 | nmod | [,] |
R4035 | T5980 | T5955 | punct | ),majority |
R4036 | T5981 | T5981 | ROOT | serve,serve |
R4037 | T5982 | T5981 | prep | as,serve |
R4038 | T5983 | T5982 | pobj | inhibitors,as |
R4039 | T5950 | T5951 | nummod | 19,] |
R4040 | T5984 | T5983 | prep | of,inhibitors |
R4041 | T5985 | T5984 | pobj | NF-κB,of |
R4042 | T5986 | T5985 | punct | ",",NF-κB |
R4043 | T5987 | T5985 | conj | IκBξ,NF-κB |
R4044 | T5988 | T5987 | cc | and,IκBξ |
R4045 | T5989 | T5987 | conj | Bcl-3,IκBξ |
R4046 | T5951 | T5945 | conj | ],translocation |
R4047 | T5990 | T5993 | nmod | instead,transactivation |
R4048 | T5991 | T5993 | amod | potentiate,transactivation |
R4049 | T5992 | T5993 | compound | NF-κB,transactivation |
R4050 | T5993 | T5983 | conj | transactivation,inhibitors |
R4051 | T5952 | T5920 | punct | .,sequestered |
R4052 | T5994 | T5993 | prep | in,transactivation |
R4053 | T5995 | T5996 | det | the,nucleus |
R4054 | T5953 | T5981 | mark | Whereas,serve |
R4055 | T5996 | T5994 | pobj | nucleus,in |
R4056 | T5997 | T5981 | punct | .,serve |
R4057 | T5998 | T6001 | nsubj | p100,are |
R4058 | T5954 | T5955 | det | the,majority |
R4059 | T5999 | T5998 | cc | and,p100 |
R4060 | T6000 | T5998 | conj | p105,p100 |
R4061 | T6001 | T6001 | ROOT | are,are |
R4062 | T6002 | T6001 | attr | precursors,are |
R4063 | T5955 | T5981 | nsubj | majority,serve |
R4064 | T6003 | T6002 | prep | of,precursors |
R4065 | T6004 | T6005 | det | the,p52 |
R4066 | T5956 | T5955 | prep | of,majority |
R4067 | T6005 | T6009 | nummod | p52,subunits |
R4068 | T6006 | T6005 | cc | and,p52 |
R4069 | T6007 | T6005 | conj | p50,p52 |
R4070 | T6008 | T6009 | amod | NF-κB,subunits |
R4072 | T6009 | T6003 | pobj | subunits,of |
R4073 | T6010 | T6009 | punct | ",",subunits |
R4074 | T6011 | T6001 | advmod | respectively,are |
R4075 | T6012 | T6001 | punct | .,are |
R4076 | T6013 | T6014 | expl | There,are |
R4077 | T6014 | T6014 | ROOT | are,are |
R4078 | T6015 | T6019 | nummod | two,pathways |
R4080 | T6016 | T6019 | amod | unique,pathways |
R4081 | T6017 | T6018 | npadvmod | NF-κB,signalling |
R4082 | T6018 | T6019 | amod | signalling,pathways |
R4083 | T6019 | T6014 | attr | pathways,are |
R4085 | T6020 | T6019 | punct | ",",pathways |
R4086 | T6021 | T6019 | acl | termed,pathways |
R4087 | T6022 | T6021 | oprd | canonical,termed |
R4088 | T6057 | T6058 | amod | proinflammatory,cytokines |
R4089 | T6023 | T6022 | punct | (,canonical |
R4090 | T6024 | T6022 | cc | or,canonical |
R4091 | T6058 | T6056 | pobj | cytokines,including |
R4092 | T6059 | T6058 | punct | (,cytokines |
R4093 | T6025 | T6022 | conj | classical,canonical |
R4094 | T6026 | T6019 | punct | ),pathways |
R4095 | T6027 | T6014 | cc | and,are |
R4096 | T6028 | T6014 | conj | noncanonical,are |
R4097 | T6029 | T6028 | punct | (,noncanonical |
R4098 | T6030 | T6028 | cc | or,noncanonical |
R4099 | T6060 | T6058 | prep | for,cytokines |
R4100 | T6031 | T6028 | conj | alternative,noncanonical |
R4101 | T6032 | T6028 | punct | ),noncanonical |
R4102 | T6061 | T6060 | pobj | example,for |
R4103 | T6033 | T6034 | compound | NF-κB,pathways |
R4104 | T6034 | T6014 | attr | pathways,are |
R4105 | T6062 | T6068 | punct | ",",antigens |
R4106 | T6035 | T6014 | punct | .,are |
R4107 | T6036 | T6039 | det | The,pathway |
R4108 | T6037 | T6039 | amod | canonical,pathway |
R4109 | T6063 | T6068 | nmod | TNF,antigens |
R4110 | T6038 | T6039 | compound | NF-κB,pathway |
R4111 | T6039 | T6040 | nsubj | pathway,plays |
R4112 | T6040 | T6040 | ROOT | plays,plays |
R4113 | T6041 | T6043 | det | a,role |
R4114 | T6064 | T6063 | punct | ",",TNF |
R4115 | T6042 | T6043 | amod | major,role |
R4116 | T6043 | T6040 | dobj | role,plays |
R4117 | T6044 | T6043 | prep | in,role |
R4118 | T6065 | T6063 | conj | IL-1,TNF |
R4119 | T6045 | T6048 | amod | innate,immunity |
R4120 | T6046 | T6045 | cc | and,innate |
R4121 | T6047 | T6045 | conj | adaptive,innate |
R4122 | T6066 | T6065 | punct | ),IL-1 |
R4123 | T6048 | T6044 | pobj | immunity,in |
R4124 | T6049 | T6040 | punct | ",",plays |
R4125 | T6050 | T6040 | cc | and,plays |
R4126 | T6067 | T6065 | punct | ",",IL-1 |
R4127 | T6051 | T6052 | auxpass | is,triggered |
R4128 | T6052 | T6040 | conj | triggered,plays |
R4129 | T6053 | T6052 | agent | by,triggered |
R4130 | T6068 | T6058 | conj | antigens,cytokines |
R4131 | T6069 | T6068 | punct | ",",antigens |
R4132 | T6070 | T6068 | conj | RANKL,antigens |
R4133 | T6071 | T6070 | punct | ",",RANKL |
R4134 | T6151 | T6150 | punct | ),IKKβ |
R4135 | T6072 | T6070 | cc | and,RANKL |
R4136 | T6152 | T6146 | cc | and,known |
R4137 | T6153 | T6155 | det | the,subunit |
R4138 | T6073 | T6070 | conj | TLR,RANKL |
R4139 | T6154 | T6155 | amod | regulatory,subunit |
R4140 | T6155 | T6146 | conj | subunit,known |
R4141 | T6156 | T6158 | nmod | NF-κB,modulator |
R4142 | T6074 | T6070 | conj | ligands,RANKL |
R4143 | T6157 | T6158 | amod | essential,modulator |
R4144 | T6158 | T6155 | appos | modulator,subunit |
R4145 | T6159 | T6163 | punct | (,known |
R4146 | T6160 | T6163 | punct | NEMO,known |
R4147 | T6161 | T6163 | punct | -,known |
R4148 | T6162 | T6163 | advmod | also,known |
R4149 | T6075 | T6040 | punct | .,plays |
R4150 | T6163 | T6155 | acl | known,subunit |
R4151 | T6164 | T6163 | prep | as,known |
R4152 | T6165 | T6164 | pobj | IKKγ,as |
R4153 | T6076 | T6077 | amod | NF-κB,signalling |
R4154 | T6166 | T6140 | punct | ),subunits |
R4155 | T6167 | T6168 | punct | (,Figure |
R4156 | T6077 | T6082 | nsubj | signalling,requires |
R4157 | T6168 | T6140 | appos | Figure,subunits |
R4158 | T6169 | T6168 | nummod | 1,Figure |
R4159 | T6078 | T6077 | acl | initiated,signalling |
R4160 | T6170 | T6168 | punct | ),Figure |
R4161 | T6171 | T6135 | punct | .,comprised |
R4162 | T6172 | T6174 | compound | Gene,experiments |
R4163 | T6173 | T6174 | compound | targeting,experiments |
R4164 | T6079 | T6078 | agent | by,initiated |
R4165 | T6174 | T6175 | nsubj | experiments,showed |
R4166 | T6175 | T6175 | ROOT | showed,showed |
R4167 | T6176 | T6186 | mark | that,required |
R4168 | T6080 | T6081 | amod | different,receptors |
R4169 | T6177 | T6186 | nsubjpass | IKK2,required |
R4170 | T6178 | T6177 | cc | and,IKK2 |
R4171 | T6081 | T6079 | pobj | receptors,by |
R4172 | T6082 | T6082 | ROOT | requires,requires |
R4173 | T6179 | T6177 | conj | NEMO,IKK2 |
R4174 | T6180 | T6177 | punct | ",",IKK2 |
R4175 | T6181 | T6177 | cc | but,IKK2 |
R4176 | T6083 | T6084 | det | the,formation |
R4177 | T6182 | T6183 | neg | not,IKK1 |
R4178 | T6183 | T6177 | conj | IKK1,IKK2 |
R4179 | T6184 | T6186 | punct | ",",required |
R4180 | T6185 | T6186 | auxpass | are,required |
R4181 | T6084 | T6082 | dobj | formation,requires |
R4182 | T6186 | T6175 | ccomp | required,showed |
R4183 | T6085 | T6084 | prep | of,formation |
R4184 | T6187 | T6186 | prep | for,required |
R4185 | T6086 | T6088 | amod | proximal,interactions |
R4186 | T6188 | T6190 | amod | canonical,activation |
R4187 | T6087 | T6088 | compound | protein-protein,interactions |
R4188 | T6189 | T6190 | compound | NF-κB,activation |
R4189 | T6190 | T6187 | pobj | activation,for |
R4190 | T6088 | T6085 | pobj | interactions,of |
R4191 | T6191 | T6193 | nmod | [,] |
R4192 | T6192 | T6193 | nummod | 21,] |
R4193 | T6193 | T6190 | appos | ],activation |
R4194 | T6194 | T6175 | punct | .,showed |
R4195 | T6195 | T6203 | nsubj | One,is |
R4196 | T6196 | T6195 | prep | of,One |
R4197 | T6089 | T6090 | nsubj | that,are |
R4198 | T6197 | T6198 | det | the,best |
R4199 | T6198 | T6199 | advmod | best,studied |
R4200 | T6199 | T6200 | amod | studied,NF-κB |
R4201 | T6090 | T6088 | relcl | are,interactions |
R4202 | T6200 | T6201 | nsubj | NF-κB,signalling |
R4203 | T6201 | T6203 | csubj | signalling,is |
R4204 | T6202 | T6201 | dobj | pathways,signalling |
R4205 | T6091 | T6090 | advmod | often,are |
R4206 | T6203 | T6203 | ROOT | is,is |
R4207 | T6204 | T6206 | det | the,pathway |
R4208 | T6205 | T6206 | compound | TNF,pathway |
R4209 | T6092 | T6093 | npadvmod | receptor,specific |
R4210 | T6206 | T6203 | attr | pathway,is |
R4211 | T6207 | T6203 | punct | .,is |
R4212 | T6093 | T6090 | acomp | specific,are |
R4213 | T6208 | T6210 | compound | TNF,results |
R4214 | T6209 | T6210 | compound | stimulation,results |
R4215 | T6210 | T6210 | ROOT | results,results |
R4216 | T6094 | T6082 | punct | ",",requires |
R4217 | T6211 | T6210 | prep | in,results |
R4218 | T6212 | T6213 | det | the,recruitment |
R4219 | T6213 | T6211 | pobj | recruitment,in |
R4220 | T6095 | T6082 | cc | but,requires |
R4221 | T6214 | T6213 | prep | of,recruitment |
R4222 | T6215 | T6218 | nmod | TNF,domain |
R4223 | T6216 | T6218 | amod | receptor-1-associated,domain |
R4224 | T6096 | T6097 | advmod | ultimately,converge |
R4225 | T6217 | T6218 | compound | death,domain |
R4226 | T6218 | T6214 | pobj | domain,of |
R4227 | T6219 | T6218 | punct | (,domain |
R4228 | T6097 | T6082 | conj | converge,requires |
R4229 | T6220 | T6218 | appos | TRADD,domain |
R4230 | T6221 | T6220 | punct | ),TRADD |
R4231 | T6222 | T6218 | conj | protein,domain |
R4232 | T6098 | T6097 | prep | in,converge |
R4233 | T6223 | T6214 | cc | and,of |
R4234 | T6224 | T6214 | conj | of,of |
R4235 | T6225 | T6227 | compound | receptor,protein |
R4236 | T6099 | T6100 | det | the,activation |
R4237 | T6226 | T6227 | compound | interacting,protein |
R4238 | T6227 | T6224 | pobj | protein,of |
R4239 | T6228 | T6227 | nummod | 1,protein |
R4240 | T6100 | T6098 | pobj | activation,in |
R4241 | T6229 | T6227 | punct | (,protein |
R4242 | T6230 | T6227 | appos | RIP1,protein |
R4243 | T6231 | T6230 | punct | ),RIP1 |
R4244 | T6232 | T6227 | punct | ",",protein |
R4245 | T6233 | T6234 | nsubj | which,function |
R4246 | T6234 | T6210 | relcl | function,results |
R4247 | T6101 | T6100 | prep | of,activation |
R4248 | T6235 | T6234 | prep | as,function |
R4249 | T6236 | T6237 | compound | adaptor,proteins |
R4250 | T6237 | T6235 | pobj | proteins,as |
R4251 | T6238 | T6234 | prep | for,function |
R4252 | T6102 | T6104 | det | the,kinase |
R4253 | T6239 | T6245 | det | the,factor |
R4254 | T6240 | T6241 | nummod | E3,ubiquitin |
R4255 | T6103 | T6104 | compound | IκB,kinase |
R4256 | T6241 | T6242 | nsubj | ubiquitin,ligases |
R4257 | T6242 | T6245 | nmod | ligases,factor |
R4258 | T6243 | T6245 | nmod | TNF,factor |
R4259 | T6104 | T6101 | pobj | kinase,of |
R4260 | T6244 | T6245 | amod | receptor-associated,factor |
R4261 | T6245 | T6238 | pobj | factor,for |
R4262 | T6105 | T6106 | punct | (,IKK |
R4263 | T6246 | T6247 | punct | (,TRAF |
R4264 | T6247 | T6245 | appos | TRAF,factor |
R4265 | T6106 | T6104 | appos | IKK,kinase |
R4266 | T6107 | T6106 | punct | ),IKK |
R4267 | T6108 | T6104 | conj | complex,kinase |
R4268 | T6109 | T6104 | punct | ",",kinase |
R4269 | T6248 | T6247 | punct | ),TRAF |
R4270 | T6249 | T6247 | nummod | 2,TRAF |
R4271 | T6110 | T6111 | nsubj | which,mediates |
R4272 | T6250 | T6247 | cc | and,TRAF |
R4273 | T6251 | T6247 | conj | TRAF5,TRAF |
R4274 | T6252 | T6245 | punct | ",",factor |
R4275 | T6111 | T6104 | relcl | mediates,kinase |
R4276 | T6253 | T6256 | nsubj | which,bind |
R4277 | T6254 | T6256 | prep | in,bind |
R4278 | T6255 | T6254 | pobj | turn,in |
R4279 | T6112 | T6111 | dobj | phosphorylation,mediates |
R4280 | T6256 | T6245 | relcl | bind,factor |
R4281 | T6113 | T6112 | prep | of,phosphorylation |
R4282 | T6114 | T6117 | det | the,protein |
R4283 | T6257 | T6260 | dobj | the,ligases |
R4284 | T6258 | T6259 | nummod | E3,ubiquitin |
R4285 | T6115 | T6117 | amod | inhibitory,protein |
R4286 | T6259 | T6260 | nsubj | ubiquitin,ligases |
R4287 | T6260 | T6256 | dative | ligases,bind |
R4288 | T6261 | T6262 | amod | cellular,inhibitor |
R4289 | T6116 | T6117 | compound | IκB,protein |
R4290 | T6262 | T6256 | dobj | inhibitor,bind |
R4291 | T6263 | T6262 | prep | of,inhibitor |
R4292 | T6117 | T6113 | pobj | protein,of |
R4293 | T6264 | T6263 | pobj | apoptosis,of |
R4294 | T6265 | T6266 | punct | (,cIAP |
R4295 | T6266 | T6264 | appos | cIAP,apoptosis |
R4296 | T6267 | T6256 | punct | ),bind |
R4297 | T6268 | T6256 | nummod | 1,bind |
R4298 | T6118 | T6117 | acl | leading,protein |
R4299 | T6269 | T6256 | cc | and,bind |
R4300 | T6270 | T6274 | nmod | cIAP2,) |
R4301 | T6271 | T6272 | punct | (,Figure |
R4302 | T6119 | T6118 | prep | to,leading |
R4303 | T6272 | T6270 | appos | Figure,cIAP2 |
R4304 | T6273 | T6272 | nummod | 1,Figure |
R4305 | T6274 | T6256 | conj | ),bind |
R4306 | T6275 | T6210 | punct | .,results |
R4307 | T6120 | T6121 | poss | its,K48-polyubiquitination |
R4308 | T6276 | T6285 | prep | On,modified |
R4309 | T6277 | T6278 | compound | TNF,stimulation |
R4310 | T6121 | T6119 | pobj | K48-polyubiquitination,to |
R4311 | T6278 | T6276 | pobj | stimulation,On |
R4312 | T6279 | T6285 | punct | ",",modified |
R4313 | T6280 | T6282 | amod | TNF-receptor,RIP1 |
R4314 | T6122 | T6121 | cc | and,K48-polyubiquitination |
R4315 | T6281 | T6282 | amod | bound,RIP1 |
R4316 | T6282 | T6285 | nsubjpass | RIP1,modified |
R4317 | T6283 | T6285 | auxpass | is,modified |
R4318 | T6123 | T6121 | conj | degradation,K48-polyubiquitination |
R4319 | T6284 | T6285 | advmod | rapidly,modified |
R4320 | T6285 | T6285 | ROOT | modified,modified |
R4321 | T6124 | T6121 | prep | by,K48-polyubiquitination |
R4322 | T6286 | T6285 | agent | by,modified |
R4323 | T6287 | T6289 | amod | K63-linked,chains |
R4324 | T6288 | T6289 | compound | polyubiquitin,chains |
R4325 | T6125 | T6129 | det | the,] |
R4326 | T6289 | T6286 | pobj | chains,by |
R4327 | T6290 | T6285 | punct | .,modified |
R4328 | T6291 | T6294 | nsubj | TRAF2/5,are |
R4329 | T6126 | T6127 | compound | proteasome,[ |
R4330 | T6292 | T6291 | cc | and,TRAF2/5 |
R4331 | T6293 | T6291 | conj | cIAP1/2,TRAF2/5 |
R4332 | T6127 | T6129 | nmod | [,] |
R4333 | T6294 | T6294 | ROOT | are,are |
R4334 | T6295 | T6296 | amod | good,candidates |
R4335 | T6296 | T6294 | attr | candidates,are |
R4336 | T6128 | T6129 | nummod | 20,] |
R4337 | T6297 | T6296 | prep | for,candidates |
R4338 | T6298 | T6299 | compound | RIP1,ubiquitination |
R4339 | T6299 | T6297 | pobj | ubiquitination,for |
R4340 | T6129 | T6124 | pobj | ],by |
R4341 | T6300 | T6294 | punct | ",",are |
R4342 | T6301 | T6294 | cc | but,are |
R4343 | T6130 | T6082 | punct | .,requires |
R4344 | T6302 | T6304 | det | the,role |
R4345 | T6303 | T6304 | amod | specific,role |
R4346 | T6304 | T6307 | nsubj | role,is |
R4347 | T6305 | T6304 | prep | of,role |
R4348 | T6306 | T6305 | pobj | each,of |
R4349 | T6307 | T6294 | conj | is,are |
R4350 | T6131 | T6133 | det | The,complex |
R4351 | T6308 | T6307 | advmod | still,is |
R4352 | T6309 | T6307 | acomp | unclear,is |
R4353 | T6310 | T6307 | punct | .,is |
R4354 | T6132 | T6133 | compound | IKK,complex |
R4355 | T6311 | T6313 | det | The,chains |
R4356 | T6312 | T6313 | compound | polyubiquitin,chains |
R4357 | T6313 | T6317 | nsubjpass | chains,believed |
R4358 | T6133 | T6135 | nsubjpass | complex,comprised |
R4359 | T6314 | T6313 | prep | on,chains |
R4360 | T6315 | T6314 | pobj | RIP1,on |
R4361 | T6134 | T6135 | auxpass | is,comprised |
R4362 | T6316 | T6317 | auxpass | are,believed |
R4363 | T6317 | T6317 | ROOT | believed,believed |
R4364 | T6318 | T6319 | aux | to,create |
R4365 | T6135 | T6135 | ROOT | comprised,comprised |
R4366 | T6319 | T6317 | xcomp | create,believed |
R4367 | T6320 | T6321 | det | a,scaffold |
R4368 | T6321 | T6319 | dobj | scaffold,create |
R4369 | T6136 | T6135 | prep | of,comprised |
R4370 | T6322 | T6323 | aux | to,recruit |
R4371 | T6323 | T6319 | advcl | recruit,create |
R4372 | T6137 | T6140 | det | the,subunits |
R4373 | T6324 | T6325 | det | the,IKK |
R4374 | T6325 | T6323 | dobj | IKK,recruit |
R4375 | T6326 | T6325 | cc | and,IKK |
R4376 | T6138 | T6140 | nummod | two,subunits |
R4377 | T6327 | T6328 | nummod | TAK1,complex |
R4378 | T6328 | T6317 | conj | complex,believed |
R4379 | T6139 | T6140 | amod | catalytic,subunits |
R4380 | T6329 | T6328 | prep | via,complex |
R4381 | T6330 | T6332 | det | the,proteins |
R4382 | T6331 | T6332 | amod | ubiquitin-binding,proteins |
R4383 | T6332 | T6329 | pobj | proteins,via |
R4384 | T6140 | T6136 | pobj | subunits,of |
R4385 | T6333 | T6332 | appos | NEMO,proteins |
R4386 | T6334 | T6333 | cc | and,NEMO |
R4387 | T6141 | T6140 | appos | IKK1,subunits |
R4388 | T6335 | T6333 | conj | TAB1/2,NEMO |
R4389 | T6142 | T6141 | cc | and,IKK1 |
R4390 | T6143 | T6141 | conj | IKK2,IKK1 |
R4391 | T6336 | T6335 | punct | ",",TAB1/2 |
R4392 | T6337 | T6333 | conj | respectively,NEMO |
R4393 | T6144 | T6146 | punct | (,known |
R4394 | T6338 | T6317 | punct | .,believed |
R4395 | T6339 | T6341 | det | The,identification |
R4396 | T6340 | T6341 | amod | recent,identification |
R4397 | T6341 | T6356 | nsubj | identification,is |
R4398 | T6342 | T6341 | prep | of,identification |
R4399 | T6343 | T6347 | det | a,complex |
R4400 | T6145 | T6146 | advmod | also,known |
R4401 | T6344 | T6347 | amod | distinct,complex |
R4402 | T6146 | T6141 | parataxis | known,IKK1 |
R4403 | T6147 | T6146 | prep | as,known |
R4404 | T6148 | T6147 | pobj | IKKα,as |
R4405 | T6345 | T6346 | nummod | E2/E3,enzyme |
R4406 | T6346 | T6347 | compound | enzyme,complex |
R4407 | T6149 | T6148 | cc | and,IKKα |
R4408 | T6347 | T6342 | pobj | complex,of |
R4409 | T6348 | T6349 | nsubj | that,modifies |
R4410 | T6349 | T6347 | relcl | modifies,complex |
R4411 | T6150 | T6148 | conj | IKKβ,IKKα |
R4412 | T6350 | T6349 | dobj | NEMO,modifies |
R4413 | T6351 | T6349 | prep | with,modifies |
R4414 | T6442 | T6443 | amod | bridging,factors |
R4415 | T6352 | T6354 | amod | linear,chains |
R4416 | T6353 | T6354 | compound | polyubiquitin,chains |
R4417 | T6354 | T6351 | pobj | chains,with |
R4418 | T6355 | T6349 | cc | and,modifies |
R4419 | T6356 | T6362 | ccomp | is,adds |
R4420 | T6357 | T6356 | acomp | essential,is |
R4421 | T6443 | T6441 | pobj | factors,as |
R4422 | T6358 | T6357 | prep | for,essential |
R4423 | T6359 | T6361 | amod | TNF-activated,signalling |
R4424 | T6444 | T6445 | aux | to,recruit |
R4425 | T6360 | T6361 | compound | NF-κB,signalling |
R4426 | T6361 | T6358 | pobj | signalling,for |
R4427 | T6362 | T6362 | ROOT | adds,adds |
R4428 | T6363 | T6364 | amod | further,complexity |
R4429 | T6445 | T6440 | advcl | recruit,serve |
R4430 | T6364 | T6362 | dobj | complexity,adds |
R4431 | T6365 | T6367 | nmod | [,] |
R4432 | T6366 | T6367 | nummod | 22,] |
R4433 | T6446 | T6450 | amod | myeloid,gene |
R4434 | T6367 | T6362 | npadvmod | ],adds |
R4435 | T6368 | T6362 | punct | .,adds |
R4436 | T6369 | T6371 | det | The,role |
R4437 | T6447 | T6450 | nmod | differentiation,gene |
R4438 | T6370 | T6371 | amod | exact,role |
R4439 | T6371 | T6376 | nsubj | role,remains |
R4440 | T6448 | T6450 | amod | primary,gene |
R4441 | T6372 | T6371 | prep | of,role |
R4442 | T6373 | T6375 | amod | protein-anchored,chains |
R4443 | T6374 | T6375 | compound | polyubiquitin,chains |
R4444 | T6375 | T6372 | pobj | chains,of |
R4445 | T6449 | T6450 | compound | response,gene |
R4446 | T6376 | T6376 | ROOT | remains,remains |
R4447 | T6377 | T6376 | acomp | unclear,remains |
R4448 | T6378 | T6376 | punct | ",",remains |
R4449 | T6379 | T6383 | mark | as,suggested |
R4450 | T6380 | T6383 | nsubjpass | it,suggested |
R4451 | T6381 | T6383 | auxpass | was,suggested |
R4452 | T6450 | T6445 | dobj | gene,recruit |
R4453 | T6382 | T6383 | advmod | recently,suggested |
R4454 | T6383 | T6376 | advcl | suggested,remains |
R4455 | T6384 | T6390 | mark | that,activate |
R4456 | T6451 | T6450 | nummod | 88,gene |
R4457 | T6385 | T6387 | amod | unanchored,chains |
R4458 | T6386 | T6387 | compound | polyubiquitin,chains |
R4459 | T6387 | T6390 | nsubj | chains,activate |
R4460 | T6388 | T6390 | aux | can,activate |
R4461 | T6452 | T6453 | punct | (,MyD88 |
R4462 | T6389 | T6390 | advmod | directly,activate |
R4463 | T6390 | T6383 | ccomp | activate,suggested |
R4464 | T6391 | T6396 | det | the,] |
R4465 | T6453 | T6450 | appos | MyD88,gene |
R4466 | T6392 | T6396 | nummod | TAK1,] |
R4467 | T6393 | T6394 | amod | complex,[ |
R4468 | T6394 | T6396 | nmod | [,] |
R4469 | T6454 | T6453 | punct | ),MyD88 |
R4470 | T6395 | T6396 | nummod | 23,] |
R4471 | T6396 | T6390 | dobj | ],activate |
R4472 | T6455 | T6440 | cc | and,serve |
R4473 | T6397 | T6376 | punct | .,remains |
R4474 | T6398 | T6400 | amod | Similar,principles |
R4475 | T6399 | T6400 | amod | signalling,principles |
R4476 | T6456 | T6459 | compound | TIR,IFNβ |
R4477 | T6400 | T6401 | nsubj | principles,apply |
R4478 | T6401 | T6401 | ROOT | apply,apply |
R4479 | T6402 | T6401 | prep | to,apply |
R4480 | T6457 | T6459 | compound | domain-containing,IFNβ |
R4481 | T6403 | T6404 | amod | other,receptors |
R4482 | T6404 | T6402 | pobj | receptors,to |
R4483 | T6405 | T6401 | punct | .,apply |
R4484 | T6458 | T6459 | compound | adaptor-inducing,IFNβ |
R4485 | T6406 | T6413 | prep | For,induces |
R4486 | T6407 | T6406 | pobj | example,For |
R4487 | T6408 | T6413 | punct | ",",induces |
R4488 | T6459 | T6432 | appos | IFNβ,molecule |
R4489 | T6409 | T6410 | nummod | TLR4,stimulation |
R4490 | T6410 | T6413 | nsubj | stimulation,induces |
R4491 | T6411 | T6410 | prep | by,stimulation |
R4492 | T6460 | T6459 | punct | (,IFNβ |
R4493 | T6412 | T6411 | pobj | lipopolysaccharide,by |
R4494 | T6413 | T6413 | ROOT | induces,induces |
R4495 | T6461 | T6459 | appos | TRIF,IFNβ |
R4496 | T6414 | T6415 | det | the,recruitment |
R4497 | T6415 | T6413 | dobj | recruitment,induces |
R4498 | T6416 | T6415 | prep | of,recruitment |
R4499 | T6462 | T6459 | punct | ),IFNβ |
R4500 | T6417 | T6421 | nmod | Toll/IL,protein |
R4501 | T6418 | T6421 | nummod | -1,protein |
R4502 | T6419 | T6420 | compound | receptor,adaptor |
R4503 | T6420 | T6421 | compound | adaptor,protein |
R4504 | T6463 | T6459 | punct | ",",IFNβ |
R4505 | T6421 | T6416 | pobj | protein,of |
R4506 | T6422 | T6424 | punct | (,referred |
R4507 | T6464 | T6459 | advmod | respectively,IFNβ |
R4508 | T6423 | T6424 | advmod | also,referred |
R4509 | T6424 | T6424 | ROOT | referred,referred |
R4510 | T6425 | T6424 | prep | to,referred |
R4511 | T6465 | T6424 | punct | .,referred |
R4512 | T6426 | T6425 | prep | as,to |
R4513 | T6427 | T6426 | pobj | Mal,as |
R4514 | T6428 | T6425 | punct | ),to |
R4515 | T6466 | T6469 | nummod | MyD88,recruits |
R4516 | T6429 | T6424 | cc | and,referred |
R4517 | T6430 | T6432 | amod | TRIF-related,molecule |
R4518 | T6431 | T6432 | compound | adaptor,molecule |
R4519 | T6467 | T6469 | prep | in,recruits |
R4520 | T6432 | T6424 | conj | molecule,referred |
R4521 | T6433 | T6434 | punct | (,TRAM |
R4522 | T6468 | T6467 | pobj | turn,in |
R4523 | T6434 | T6432 | appos | TRAM,molecule |
R4524 | T6435 | T6434 | punct | ),TRAM |
R4525 | T6436 | T6432 | punct | ",",molecule |
R4526 | T6469 | T6469 | ROOT | recruits,recruits |
R4527 | T6437 | T6440 | nsubj | which,serve |
R4528 | T6438 | T6439 | advmod | most,probably |
R4529 | T6439 | T6440 | advmod | probably,serve |
R4530 | T6440 | T6432 | relcl | serve,molecule |
R4531 | T6470 | T6469 | dobj | members,recruits |
R4532 | T6441 | T6440 | prep | as,serve |
R4533 | T6471 | T6470 | prep | of,members |
R4534 | T6472 | T6474 | det | the,kinase |
R4535 | T6473 | T6474 | amod | IL-1R-associated,kinase |
R4536 | T6539 | T6542 | det | the,receptor |
R4537 | T6540 | T6542 | nmod | lymphotoxin,receptor |
R4538 | T6474 | T6471 | pobj | kinase,of |
R4539 | T6541 | T6542 | compound | β,receptor |
R4540 | T6542 | T6538 | pobj | receptor,by |
R4541 | T6475 | T6474 | punct | (,kinase |
R4542 | T6543 | T6542 | punct | ",",receptor |
R4543 | T6544 | T6545 | compound | BAFF,receptor |
R4544 | T6545 | T6542 | conj | receptor,receptor |
R4545 | T6476 | T6474 | appos | IRAK,kinase |
R4546 | T6546 | T6545 | punct | ",",receptor |
R4547 | T6547 | T6545 | conj | CD40,receptor |
R4548 | T6548 | T6547 | punct | ",",CD40 |
R4549 | T6549 | T6547 | cc | and,CD40 |
R4550 | T6550 | T6547 | conj | RANK,CD40 |
R4551 | T6551 | T6552 | punct | (,Figure |
R4552 | T6552 | T6550 | appos | Figure,RANK |
R4553 | T6477 | T6476 | punct | ),IRAK |
R4554 | T6478 | T6474 | conj | family,kinase |
R4555 | T6553 | T6552 | nummod | 2,Figure |
R4556 | T6479 | T6478 | cc | and,family |
R4557 | T6554 | T6550 | punct | ),RANK |
R4558 | T6555 | T6537 | punct | .,activated |
R4559 | T6480 | T6478 | conj | TRAF6,family |
R4560 | T6556 | T6562 | prep | In,processed |
R4561 | T6557 | T6558 | det | this,pathway |
R4562 | T6481 | T6469 | punct | ",",recruits |
R4563 | T6558 | T6556 | pobj | pathway,In |
R4564 | T6559 | T6562 | punct | ",",processed |
R4565 | T6560 | T6562 | nsubjpass | p100,processed |
R4566 | T6561 | T6562 | auxpass | is,processed |
R4567 | T6482 | T6469 | advcl | leading,recruits |
R4568 | T6562 | T6562 | ROOT | processed,processed |
R4569 | T6563 | T6562 | agent | by,processed |
R4570 | T6483 | T6482 | prep | to,leading |
R4571 | T6564 | T6565 | det | the,proteasome |
R4572 | T6565 | T6563 | pobj | proteasome,by |
R4573 | T6566 | T6565 | prep | to,proteasome |
R4574 | T6484 | T6483 | pobj | oligomerisation,to |
R4575 | T6567 | T6566 | pobj | p52,to |
R4576 | T6568 | T6567 | punct | ",",p52 |
R4577 | T6485 | T6484 | cc | and,oligomerisation |
R4578 | T6569 | T6576 | nsubj | which,regulates |
R4579 | T6486 | T6484 | conj | selfubiquitination,oligomerisation |
R4580 | T6570 | T6571 | advmod | together,with |
R4581 | T6487 | T6486 | prep | of,selfubiquitination |
R4582 | T6571 | T6576 | prep | with,regulates |
R4583 | T6572 | T6575 | det | the,subunit |
R4584 | T6488 | T6491 | nummod | TRAF6,] |
R4585 | T6573 | T6575 | compound | RelB,subunit |
R4586 | T6574 | T6575 | compound | NF-κB,subunit |
R4587 | T6575 | T6571 | pobj | subunit,with |
R4588 | T6576 | T6565 | relcl | regulates,proteasome |
R4589 | T6489 | T6491 | nmod | [,] |
R4590 | T6577 | T6579 | det | a,set |
R4591 | T6578 | T6579 | amod | distinct,set |
R4592 | T6490 | T6491 | nummod | 24,] |
R4593 | T6579 | T6576 | dobj | set,regulates |
R4594 | T6580 | T6579 | prep | of,set |
R4595 | T6581 | T6582 | compound | target,genes |
R4596 | T6491 | T6487 | pobj | ],of |
R4597 | T6582 | T6580 | pobj | genes,of |
R4598 | T6583 | T6584 | nsubj | that,control |
R4599 | T6584 | T6582 | relcl | control,genes |
R4600 | T6585 | T6586 | amod | B-cell,development |
R4601 | T6586 | T6584 | dobj | development,control |
R4602 | T6587 | T6586 | punct | ",",development |
R4603 | T6588 | T6591 | amod | secondary,development |
R4604 | T6589 | T6591 | amod | lymphoid,development |
R4605 | T6492 | T6469 | punct | .,recruits |
R4606 | T6590 | T6591 | compound | organ,development |
R4607 | T6591 | T6586 | conj | development,development |
R4608 | T6592 | T6591 | punct | ",",development |
R4609 | T6593 | T6591 | cc | and,development |
R4610 | T6493 | T6495 | nsubj | TRIF,recruits |
R4611 | T6594 | T6595 | compound | osteoclastogenesis,[ |
R4612 | T6595 | T6579 | appos | [,set |
R4613 | T6596 | T6597 | nummod | 27,] |
R4614 | T6494 | T6495 | advmod | also,recruits |
R4615 | T6597 | T6597 | ROOT | ],] |
R4616 | T6598 | T6601 | det | The,pathway |
R4617 | T6599 | T6601 | amod | noncanonical,pathway |
R4618 | T6495 | T6495 | ROOT | recruits,recruits |
R4619 | T6600 | T6601 | compound | NF-κB,pathway |
R4620 | T6601 | T6602 | nsubj | pathway,is |
R4621 | T6496 | T6499 | nummod | TRAF6,] |
R4622 | T6602 | T6602 | ROOT | is,is |
R4623 | T6603 | T6604 | advmod | strictly,dependent |
R4624 | T6604 | T6602 | acomp | dependent,is |
R4625 | T6605 | T6604 | prep | on,dependent |
R4626 | T6497 | T6499 | nmod | [,] |
R4627 | T6606 | T6605 | pobj | IKK1,on |
R4628 | T6498 | T6499 | nummod | 25,] |
R4629 | T6607 | T6606 | punct | ",",IKK1 |
R4630 | T6608 | T6610 | nsubjpass | which,activated |
R4631 | T6609 | T6610 | auxpass | is,activated |
R4632 | T6499 | T6495 | dobj | ],recruits |
R4633 | T6610 | T6606 | relcl | activated,IKK1 |
R4634 | T6611 | T6610 | prep | upon,activated |
R4635 | T6612 | T6611 | pobj | phosphorylation,upon |
R4636 | T6613 | T6610 | agent | by,activated |
R4637 | T6500 | T6499 | cc | and,] |
R4638 | T6614 | T6615 | advmod | NF-κB,inducing |
R4639 | T6615 | T6613 | pcomp | inducing,by |
R4640 | T6616 | T6615 | dobj | kinase,inducing |
R4641 | T6501 | T6502 | compound | RIP1,[ |
R4642 | T6617 | T6618 | punct | (,NIK |
R4643 | T6618 | T6616 | parataxis | NIK,kinase |
R4644 | T6619 | T6618 | punct | ),NIK |
R4645 | T6502 | T6499 | conj | [,] |
R4646 | T6620 | T6602 | punct | .,is |
R4647 | T6621 | T6624 | nsubjpass | NIK,regulated |
R4648 | T6622 | T6624 | auxpass | is,regulated |
R4649 | T6623 | T6624 | advmod | predominantly,regulated |
R4650 | T6624 | T6624 | ROOT | regulated,regulated |
R4651 | T6625 | T6624 | prep | at,regulated |
R4652 | T6503 | T6504 | nummod | 26,] |
R4653 | T6626 | T6628 | det | the,level |
R4654 | T6627 | T6628 | amod | post-translational,level |
R4655 | T6628 | T6625 | pobj | level,at |
R4656 | T6629 | T6624 | cc | and,regulated |
R4657 | T6504 | T6499 | conj | ],] |
R4658 | T6630 | T6624 | conj | is,regulated |
R4659 | T6631 | T6630 | acomp | present,is |
R4660 | T6632 | T6631 | prep | at,present |
R4661 | T6505 | T6495 | prep | via,recruits |
R4662 | T6633 | T6634 | advmod | extremely,low |
R4663 | T6634 | T6635 | amod | low,levels |
R4664 | T6506 | T6508 | det | a,interaction |
R4665 | T6635 | T6632 | pobj | levels,at |
R4666 | T6507 | T6508 | amod | direct,interaction |
R4667 | T6508 | T6505 | pobj | interaction,via |
R4668 | T6636 | T6635 | prep | in,levels |
R4669 | T6509 | T6495 | punct | .,recruits |
R4670 | T6637 | T6639 | amod | most,types |
R4671 | T6638 | T6639 | compound | cell,types |
R4672 | T6639 | T6636 | pobj | types,in |
R4673 | T6510 | T6511 | det | Both,pathways |
R4674 | T6640 | T6630 | punct | .,is |
R4675 | T6641 | T6646 | prep | In,occurs |
R4676 | T6511 | T6513 | nsubj | pathways,activate |
R4677 | T6642 | T6643 | amod | unstimulated,cells |
R4678 | T6643 | T6641 | pobj | cells,In |
R4679 | T6644 | T6646 | punct | ",",occurs |
R4680 | T6512 | T6513 | advmod | then,activate |
R4681 | T6645 | T6646 | nsubj | NIK,occurs |
R4682 | T6646 | T6646 | ROOT | occurs,occurs |
R4683 | T6513 | T6513 | ROOT | activate,activate |
R4684 | T6647 | T6646 | prep | in,occurs |
R4685 | T6514 | T6513 | dobj | TAK1,activate |
R4686 | T6515 | T6514 | cc | and,TAK1 |
R4687 | T6648 | T6650 | det | a,complex |
R4688 | T6649 | T6650 | compound | cytoplasmic,complex |
R4689 | T6516 | T6514 | conj | IKK,TAK1 |
R4690 | T6650 | T6647 | pobj | complex,in |
R4691 | T6651 | T6650 | prep | with,complex |
R4692 | T6517 | T6514 | prep | in,TAK1 |
R4693 | T6652 | T6651 | pobj | TRAF2,with |
R4694 | T6653 | T6652 | punct | ",",TRAF2 |
R4695 | T6654 | T6652 | conj | TRAF3,TRAF2 |
R4696 | T6518 | T6520 | det | a,manner |
R4697 | T6655 | T6646 | punct | ",",occurs |
R4698 | T6656 | T6646 | cc | and,occurs |
R4699 | T6657 | T6663 | nsubj | cIAP1/2,leading |
R4700 | T6658 | T6657 | punct | ",",cIAP1/2 |
R4701 | T6659 | T6660 | nsubj | which,K48-polyubiquitinates |
R4702 | T6519 | T6520 | amod | ubiquitination-dependent,manner |
R4703 | T6660 | T6657 | relcl | K48-polyubiquitinates,cIAP1/2 |
R4704 | T6661 | T6660 | dobj | NIK,K48-polyubiquitinates |
R4705 | T6662 | T6657 | punct | ",",cIAP1/2 |
R4706 | T6520 | T6517 | pobj | manner,in |
R4707 | T6663 | T6646 | conj | leading,occurs |
R4708 | T6664 | T6663 | prep | to,leading |
R4709 | T6665 | T6667 | poss | its,degradation |
R4710 | T6521 | T6520 | amod | similar,manner |
R4711 | T6666 | T6667 | amod | continuous,degradation |
R4712 | T6667 | T6664 | pobj | degradation,to |
R4713 | T6668 | T6667 | prep | by,degradation |
R4714 | T6522 | T6521 | prep | to,similar |
R4715 | T6669 | T6670 | det | the,proteasome |
R4716 | T6670 | T6668 | pobj | proteasome,by |
R4717 | T6671 | T6663 | punct | .,leading |
R4718 | T6523 | T6525 | det | the,pathway |
R4719 | T6672 | T6673 | compound | Receptor,ligation |
R4720 | T6673 | T6676 | nsubjpass | ligation,shown |
R4721 | T6674 | T6676 | aux | has,shown |
R4722 | T6524 | T6525 | compound | TNF,pathway |
R4723 | T6675 | T6676 | auxpass | been,shown |
R4724 | T6676 | T6676 | ROOT | shown,shown |
R4725 | T6677 | T6680 | preconj | not,remove |
R4726 | T6525 | T6522 | pobj | pathway,to |
R4727 | T6678 | T6677 | advmod | only,not |
R4728 | T6679 | T6680 | aux | to,remove |
R4729 | T6680 | T6676 | xcomp | remove,shown |
R4730 | T6526 | T6525 | punct | (,pathway |
R4731 | T6681 | T6680 | dobj | TRAF3,remove |
R4732 | T6682 | T6680 | prep | from,remove |
R4733 | T6683 | T6684 | det | this,complex |
R4734 | T6527 | T6525 | appos | Figure,pathway |
R4735 | T6684 | T6682 | pobj | complex,from |
R4736 | T6685 | T6680 | prep | by,remove |
R4737 | T6686 | T6685 | pcomp | recruiting,by |
R4738 | T6528 | T6527 | nummod | 1,Figure |
R4739 | T6687 | T6686 | dobj | it,recruiting |
R4740 | T6688 | T6686 | prep | to,recruiting |
R4741 | T6529 | T6525 | punct | ),pathway |
R4742 | T6689 | T6690 | det | the,receptor |
R4743 | T6690 | T6688 | pobj | receptor,to |
R4744 | T6691 | T6680 | punct | ",",remove |
R4745 | T6530 | T6513 | punct | .,activate |
R4746 | T6692 | T6680 | cc | but,remove |
R4747 | T6693 | T6692 | advmod | also,but |
R4748 | T6694 | T6695 | aux | to,attract |
R4749 | T6695 | T6680 | conj | attract,remove |
R4750 | T6696 | T6695 | dobj | TRAF2,attract |
R4751 | T6697 | T6695 | cc | and,attract |
R4752 | T6531 | T6534 | det | The,pathway |
R4753 | T6698 | T6695 | conj | cIAP1/2,attract |
R4754 | T6699 | T6698 | punct | ",",cIAP1/2 |
R4755 | T6700 | T6701 | nsubj | which,are |
R4756 | T6532 | T6534 | amod | noncanonical,pathway |
R4757 | T6701 | T6698 | relcl | are,cIAP1/2 |
R4758 | T6702 | T6701 | acomp | essential,are |
R4759 | T6703 | T6702 | prep | for,essential |
R4760 | T6533 | T6534 | compound | NF-κB,pathway |
R4761 | T6704 | T6706 | amod | subsequent,degradation |
R4762 | T6705 | T6706 | nummod | TRAF3,degradation |
R4763 | T6534 | T6537 | nsubjpass | pathway,activated |
R4764 | T6706 | T6703 | pobj | degradation,for |
R4765 | T6707 | T6676 | punct | .,shown |
R4766 | T6708 | T6709 | predet | All,this |
R4767 | T6535 | T6537 | aux | can,activated |
R4768 | T6709 | T6710 | nsubj | this,contributes |
R4769 | T6710 | T6710 | ROOT | contributes,contributes |
R4770 | T6536 | T6537 | auxpass | be,activated |
R4771 | T6711 | T6710 | prep | to,contributes |
R4772 | T6712 | T6711 | pcomp | releasing,to |
R4773 | T6713 | T6712 | dobj | NIK,releasing |
R4774 | T6537 | T6537 | ROOT | activated,activated |
R4775 | T6714 | T6710 | prep | from,contributes |
R4776 | T6715 | T6717 | poss | its,degradation |
R4777 | T6716 | T6717 | amod | constitutive,degradation |
R4778 | T6538 | T6537 | agent | by,activated |
R4779 | T6717 | T6714 | pobj | degradation,from |
R4780 | T6718 | T6710 | punct | ",",contributes |
R4781 | T6719 | T6710 | advcl | resulting,contributes |
R4782 | T6733 | T6710 | punct | .,contributes |
R4783 | T6720 | T6719 | prep | in,resulting |
R4784 | T6721 | T6722 | compound | NIK,accumulation |
R4785 | T6722 | T6720 | pobj | accumulation,in |
R4786 | T6723 | T6722 | cc | and,accumulation |
R4787 | T6724 | T6725 | nummod | IKK1,phosphorylation |
R4788 | T6734 | T6737 | nsubjpass | It,mentioned |
R4789 | T6725 | T6728 | compound | phosphorylation,] |
R4790 | T6726 | T6728 | compound | [,] |
R4791 | T6735 | T6737 | aux | should,mentioned |
R4792 | T6727 | T6728 | compound | "28,29",] |
R4793 | T6728 | T6728 | ROOT | ],] |
R4794 | T6736 | T6737 | auxpass | be,mentioned |
R4795 | T6729 | T6730 | punct | (,Figure |
R4796 | T6730 | T6728 | appos | Figure,] |
R4797 | T6731 | T6730 | nummod | 2,Figure |
R4798 | T6732 | T6730 | punct | ),Figure |
R4799 | T6737 | T6737 | ROOT | mentioned,mentioned |
R4800 | T6738 | T6746 | mark | that,mediate |
R4801 | T6739 | T6746 | nsubj | CD40,mediate |
R4802 | T6830 | T6828 | pobj | cells,in |
R4803 | T6831 | T6833 | nsubjpass | TRAF6,required |
R4804 | T6740 | T6739 | punct | ",",CD40 |
R4805 | T6832 | T6833 | auxpass | is,required |
R4806 | T6833 | T6833 | ROOT | required,required |
R4807 | T6834 | T6833 | prep | for,required |
R4808 | T6835 | T6837 | amod | CD40-mediated,activation |
R4809 | T6741 | T6743 | nmod | lymphotoxin,receptor |
R4810 | T6836 | T6837 | compound | JNK,activation |
R4811 | T6837 | T6834 | pobj | activation,for |
R4812 | T6742 | T6743 | compound | β,receptor |
R4813 | T6838 | T6837 | cc | and,activation |
R4814 | T6839 | T6837 | conj | IL-6,activation |
R4815 | T6840 | T6837 | conj | production,activation |
R4816 | T6743 | T6739 | appos | receptor,CD40 |
R4817 | T6841 | T6833 | punct | ",",required |
R4818 | T6842 | T6845 | mark | while,required |
R4819 | T6843 | T6845 | nsubjpass | TRAF2,required |
R4820 | T6744 | T6743 | cc | and,receptor |
R4821 | T6844 | T6845 | auxpass | is,required |
R4822 | T6845 | T6833 | advcl | required,required |
R4823 | T6846 | T6845 | prep | for,required |
R4824 | T6745 | T6743 | conj | RANK,receptor |
R4825 | T6847 | T6846 | pobj | activation,for |
R4826 | T6848 | T6847 | prep | of,activation |
R4827 | T6849 | T6848 | pobj | NF-κB,of |
R4828 | T6746 | T6737 | ccomp | mediate,mentioned |
R4829 | T6850 | T6845 | punct | ",",required |
R4830 | T6851 | T6833 | cc | and,required |
R4831 | T6747 | T6748 | det | the,activation |
R4832 | T6852 | T6853 | nsubj | TRAF3,serves |
R4833 | T6853 | T6833 | conj | serves,required |
R4834 | T6854 | T6853 | prep | as,serves |
R4835 | T6748 | T6746 | dobj | activation,mediate |
R4836 | T6855 | T6857 | det | a,regulator |
R4837 | T6856 | T6857 | amod | negative,regulator |
R4838 | T6749 | T6748 | prep | of,activation |
R4839 | T6857 | T6854 | pobj | regulator,as |
R4840 | T6858 | T6857 | prep | of,regulator |
R4841 | T6859 | T6860 | nsubj | CD40,signalling |
R4842 | T6750 | T6751 | preconj | both,canonical |
R4843 | T6860 | T6858 | pcomp | signalling,of |
R4844 | T6861 | T6863 | compound | [,] |
R4845 | T6751 | T6756 | amod | canonical,pathways |
R4846 | T6862 | T6863 | compound | "30,31",] |
R4847 | T6863 | T6860 | dobj | ],signalling |
R4848 | T6864 | T6853 | punct | .,serves |
R4849 | T6752 | T6751 | cc | and,canonical |
R4850 | T6753 | T6751 | conj | noncanonical,canonical |
R4851 | T6754 | T6755 | npadvmod | NF-κB,signalling |
R4852 | T6755 | T6756 | amod | signalling,pathways |
R4853 | T6756 | T6749 | pobj | pathways,of |
R4854 | T6757 | T6737 | punct | .,mentioned |
R4855 | T6758 | T6787 | prep | Upon,leads |
R4856 | T6759 | T6758 | pobj | binding,Upon |
R4857 | T6760 | T6759 | prep | of,binding |
R4858 | T6761 | T6762 | poss | their,ligand |
R4859 | T6762 | T6760 | pobj | ligand,of |
R4860 | T6763 | T6762 | punct | ",",ligand |
R4861 | T6764 | T6762 | appos | CD40,ligand |
R4862 | T6765 | T6764 | cc | and,CD40 |
R4863 | T6766 | T6767 | compound | RANK,interact |
R4864 | T6767 | T6787 | nsubj | interact,leads |
R4865 | T6768 | T6767 | prep | with,interact |
R4866 | T6769 | T6771 | amod | several,members |
R4867 | T6770 | T6771 | compound | TRAF,members |
R4868 | T6771 | T6768 | pobj | members,with |
R4869 | T6772 | T6771 | punct | ",",members |
R4870 | T6773 | T6771 | prep | including,members |
R4871 | T6774 | T6773 | pobj | TRAF1,including |
R4872 | T6775 | T6774 | punct | ",",TRAF1 |
R4873 | T6776 | T6774 | conj | TRAF2,TRAF1 |
R4874 | T6777 | T6771 | punct | ",",members |
R4875 | T6778 | T6771 | appos | TRAF3,members |
R4876 | T6779 | T6778 | punct | ",",TRAF3 |
R4877 | T6780 | T6778 | conj | TRAF5,TRAF3 |
R4878 | T6781 | T6767 | punct | ",",interact |
R4879 | T6782 | T6767 | cc | and,interact |
R4880 | T6783 | T6767 | conj | TRAF6,interact |
R4881 | T6784 | T6783 | punct | ",",TRAF6 |
R4882 | T6785 | T6783 | cc | and,TRAF6 |
R4883 | T6786 | T6787 | nsubj | this,leads |
R4884 | T6787 | T6787 | ROOT | leads,leads |
R4885 | T6788 | T6787 | prep | to,leads |
R4886 | T6789 | T6790 | det | the,proteolysis |
R4887 | T6790 | T6788 | pobj | proteolysis,to |
R4888 | T6791 | T6790 | prep | of,proteolysis |
R4889 | T6792 | T6793 | det | both,TRAF2 |
R4890 | T6793 | T6791 | pobj | TRAF2,of |
R4891 | T6794 | T6793 | cc | and,TRAF2 |
R4892 | T6795 | T6793 | conj | TRAF3,TRAF2 |
R4893 | T6796 | T6790 | punct | ",",proteolysis |
R4894 | T6797 | T6798 | nsubj | which,represents |
R4895 | T6798 | T6790 | relcl | represents,proteolysis |
R4896 | T6799 | T6801 | det | an,step |
R4897 | T6800 | T6801 | amod | important,step |
R4898 | T6801 | T6798 | dobj | step,represents |
R4899 | T6802 | T6801 | prep | in,step |
R4900 | T6803 | T6804 | det | the,activation |
R4901 | T6804 | T6802 | pobj | activation,in |
R4902 | T6805 | T6804 | prep | of,activation |
R4904 | T6806 | T6808 | det | the,pathway |
R4908 | T6807 | T6808 | amod | noncanonical,pathway |
R4912 | T6808 | T6805 | pobj | pathway,of |
R4914 | T6809 | T6810 | mark | as,described |
R4917 | T6810 | T6798 | advcl | described,represents |
R4918 | T6811 | T6810 | advmod | above,described |
R4920 | T6812 | T6787 | punct | .,leads |
R4921 | T6813 | T6815 | amod | Specific,molecules |
R4923 | T6814 | T6815 | compound | TRAF,molecules |
R4926 | T6815 | T6817 | nsubjpass | molecules,associated |
R4929 | T6816 | T6817 | auxpass | are,associated |
R4931 | T6817 | T6817 | ROOT | associated,associated |
R4934 | T6818 | T6817 | prep | with,associated |
R4938 | T6819 | T6818 | pobj | overlapping,with |
R4941 | T6820 | T6819 | cc | and,overlapping |
R4943 | T6821 | T6823 | amod | distinct,functions |
R4948 | T6822 | T6823 | amod | CD40-mediated,functions |
R4949 | T6823 | T6819 | conj | functions,overlapping |
R4950 | T6824 | T6817 | punct | .,associated |
R4951 | T6825 | T6833 | prep | For,required |
R4953 | T6826 | T6825 | pobj | example,For |
R4955 | T6827 | T6833 | punct | ",",required |
R4957 | T6828 | T6833 | prep | in,required |
R4958 | T6829 | T6830 | compound | B,cells |
R5922 | T8788 | T8789 | compound | NF-κB,activation |
R5923 | T8789 | T8790 | nsubj | activation,is |
R5924 | T8790 | T8811 | advcl | is,is |
R5925 | T8791 | T8792 | advmod | so,crucial |
R5926 | T8792 | T8790 | acomp | crucial,is |
R5927 | T8793 | T8792 | prep | to,crucial |
R5928 | T8794 | T8796 | amod | many,processes |
R5929 | T8795 | T8796 | amod | cellular,processes |
R5930 | T8796 | T8793 | pobj | processes,to |
R5931 | T8797 | T8811 | punct | ",",is |
R5932 | T8798 | T8800 | det | a,regulation |
R5933 | T8799 | T8800 | amod | tight,regulation |
R5934 | T8800 | T8811 | nsubj | regulation,is |
R5935 | T8801 | T8800 | prep | of,regulation |
R5936 | T8802 | T8805 | det | the,pathway |
R5937 | T8803 | T8805 | nmod | NF-κB,pathway |
R5938 | T8804 | T8805 | amod | signalling,pathway |
R5939 | T8805 | T8801 | pobj | pathway,of |
R5940 | T8806 | T8805 | cc | and,pathway |
R5941 | T8807 | T8808 | det | the,genes |
R5942 | T8808 | T8805 | conj | genes,pathway |
R5943 | T8809 | T8810 | nsubj | it,induces |
R5944 | T8810 | T8808 | relcl | induces,genes |
R5945 | T8811 | T8811 | ROOT | is,is |
R5946 | T8812 | T8814 | det | an,requirement |
R5947 | T8813 | T8814 | amod | absolute,requirement |
R5948 | T8814 | T8811 | attr | requirement,is |
R5949 | T8815 | T8816 | aux | to,fine-tune |
R5950 | T8816 | T8814 | acl | fine-tune,requirement |
R5951 | T8817 | T8819 | det | the,response |
R5952 | T8818 | T8819 | amod | inflammatory,response |
R5953 | T8819 | T8816 | dobj | response,fine-tune |
R5954 | T8820 | T8811 | punct | .,is |
R5955 | T8821 | T8827 | advmod | Moreover,is |
R5956 | T8822 | T8827 | punct | ",",is |
R5957 | T8823 | T8827 | csubj | terminating,is |
R5958 | T8824 | T8826 | det | an,response |
R5959 | T8825 | T8826 | amod | NF-κB,response |
R5960 | T8826 | T8823 | dobj | response,terminating |
R5961 | T8827 | T8827 | ROOT | is,is |
R5962 | T8828 | T8827 | acomp | essential,is |
R5963 | T8829 | T8830 | aux | to,prevent |
R5964 | T8830 | T8827 | xcomp | prevent,is |
R5965 | T8831 | T8833 | amod | persistent,activation |
R5966 | T8832 | T8833 | compound | NF-κB,activation |
R5967 | T8833 | T8830 | dobj | activation,prevent |
R5968 | T8834 | T8836 | nsubj | that,lead |
R5969 | T8835 | T8836 | aux | may,lead |
R5970 | T8836 | T8833 | relcl | lead,activation |
R5971 | T8837 | T8836 | prep | to,lead |
R5972 | T8838 | T8839 | amod | chronic,inflammation |
R5973 | T8839 | T8837 | pobj | inflammation,to |
R5974 | T8840 | T8839 | cc | and/or,inflammation |
R5975 | T8841 | T8839 | conj | tumorigenesis,inflammation |
R5976 | T8842 | T8827 | punct | .,is |
R5977 | T8843 | T8844 | aux | To,achieve |
R5978 | T8844 | T8848 | advcl | achieve,employ |
R5979 | T8845 | T8844 | dobj | this,achieve |
R5980 | T8846 | T8848 | punct | ",",employ |
R5981 | T8847 | T8848 | nsubj | cells,employ |
R5982 | T8848 | T8848 | ROOT | employ,employ |
R5983 | T8849 | T8850 | amod | different,mechanisms |
R5984 | T8850 | T8848 | dobj | mechanisms,employ |
R5985 | T8851 | T8850 | punct | ",",mechanisms |
R5986 | T8852 | T8850 | prep | including,mechanisms |
R5987 | T8853 | T8854 | det | the,expression |
R5988 | T8854 | T8852 | pobj | expression,including |
R5989 | T8855 | T8854 | prep | of,expression |
R5990 | T8856 | T8857 | amod | inhibitory,proteins |
R5991 | T8857 | T8855 | pobj | proteins,of |
R5992 | T8858 | T8861 | nsubj | that,signalling |
R5993 | T8859 | T8861 | dep | downregulate,signalling |
R5994 | T8860 | T8861 | amod | NF-κB,signalling |
R5995 | T8861 | T8854 | relcl | signalling,expression |
R5996 | T8862 | T8864 | nmod | [,] |
R5997 | T8863 | T8864 | nummod | 32,] |
R5998 | T8864 | T8861 | dobj | ],signalling |
R5999 | T8865 | T8848 | punct | .,employ |
R6000 | T8866 | T8868 | advmod | Below,give |
R6001 | T8867 | T8868 | nsubj | we,give |
R6002 | T8868 | T8868 | ROOT | give,give |
R6003 | T8869 | T8870 | det | an,overview |
R6004 | T8870 | T8868 | dobj | overview,give |
R6005 | T8871 | T8870 | prep | of,overview |
R6006 | T8872 | T8873 | det | a,number |
R6007 | T8873 | T8871 | pobj | number,of |
R6008 | T8874 | T8873 | prep | of,number |
R6009 | T8875 | T8874 | pobj | proteins,of |
R6010 | T8876 | T8878 | nsubjpass | that,involved |
R6011 | T8877 | T8878 | auxpass | are,involved |
R6012 | T8878 | T8875 | relcl | involved,proteins |
R6013 | T8879 | T8878 | prep | in,involved |
R6014 | T8880 | T8881 | det | the,dampening |
R6015 | T8881 | T8879 | pobj | dampening,in |
R6016 | T8882 | T8881 | cc | or,dampening |
R6017 | T8883 | T8881 | conj | termination,dampening |
R6018 | T8884 | T8883 | prep | of,termination |
R6019 | T8885 | T8887 | det | the,response |
R6020 | T8886 | T8887 | compound | NF-κB,response |
R6021 | T8887 | T8884 | pobj | response,of |
R6022 | T8888 | T8870 | punct | ",",overview |
R6023 | T8889 | T8900 | nsubj | some,acting |
R6024 | T8890 | T8889 | prep | of,some |
R6025 | T8891 | T8890 | pobj | them,of |
R6026 | T8892 | T8889 | prep | under,some |
R6027 | T8893 | T8894 | det | the,control |
R6028 | T8894 | T8892 | pobj | control,under |
R6029 | T8895 | T8894 | prep | of,control |
R6030 | T8896 | T8895 | pobj | NF-κB,of |
R6031 | T8897 | T8896 | dobj | itself,NF-κB |
R6032 | T8898 | T8896 | cc | and,NF-κB |
R6033 | T8899 | T8900 | advmod | thus,acting |
R6034 | T8900 | T8870 | acl | acting,overview |
R6035 | T8901 | T8900 | prep | in,acting |
R6036 | T8902 | T8905 | det | a,loop |
R6037 | T8903 | T8905 | amod | negative,loop |
R6038 | T8904 | T8905 | compound | feedback,loop |
R6039 | T8905 | T8901 | pobj | loop,in |
R6040 | T8906 | T8868 | punct | .,give |
R6041 | T8907 | T8911 | prep | In,discuss |
R6042 | T8908 | T8907 | pobj | addition,In |
R6043 | T8909 | T8911 | punct | ",",discuss |
R6044 | T8910 | T8911 | nsubj | we,discuss |
R6045 | T8911 | T8911 | ROOT | discuss,discuss |
R6046 | T8912 | T8914 | det | the,role |
R6047 | T8913 | T8914 | amod | potential,role |
R6048 | T8914 | T8911 | dobj | role,discuss |
R6049 | T8915 | T8914 | prep | of,role |
R6050 | T8916 | T8919 | det | these,factors |
R6051 | T8917 | T8919 | amod | NF-κB,factors |
R6052 | T8918 | T8919 | compound | inhibitory,factors |
R6053 | T8919 | T8915 | pobj | factors,of |
R6054 | T8920 | T8914 | prep | in,role |
R6055 | T8921 | T8922 | det | the,immunopathology |
R6056 | T8922 | T8920 | pobj | immunopathology,in |
R6057 | T8923 | T8922 | prep | of,immunopathology |
R6058 | T8924 | T8923 | pobj | RA,of |
R6059 | T8925 | T8911 | punct | .,discuss |
R6060 | T8926 | T8928 | amod | Several,proteins |
R6061 | T8927 | T8928 | amod | other,proteins |
R6062 | T8928 | T8950 | nsubjpass | proteins,described |
R6063 | T8929 | T8928 | acl | involved,proteins |
R6064 | T8930 | T8929 | prep | in,involved |
R6065 | T8931 | T8933 | det | the,regulation |
R6066 | T8932 | T8933 | amod | negative,regulation |
R6067 | T8933 | T8930 | pobj | regulation,in |
R6068 | T8934 | T8933 | prep | of,regulation |
R6069 | T8935 | T8937 | amod | NF-κB-dependent,responses |
R6070 | T8936 | T8937 | amod | inflammatory,responses |
R6071 | T8937 | T8934 | pobj | responses,of |
R6072 | T8938 | T8937 | punct | ",",responses |
R6073 | T8939 | T8940 | amod | such,as |
R6074 | T8940 | T8937 | prep | as,responses |
R6075 | T8941 | T8940 | pobj | MyD88s,as |
R6076 | T8942 | T8941 | punct | ",",MyD88s |
R6077 | T8943 | T8941 | conj | IRAK-M,MyD88s |
R6078 | T8944 | T8943 | punct | ",",IRAK-M |
R6079 | T8945 | T8943 | cc | and,IRAK-M |
R6080 | T8946 | T8943 | conj | TOLLIP,IRAK-M |
R6081 | T8947 | T8950 | punct | ",",described |
R6082 | T8948 | T8950 | aux | have,described |
R6083 | T8949 | T8950 | auxpass | been,described |
R6084 | T8950 | T8950 | ROOT | described,described |
R6085 | T8951 | T8950 | punct | (,described |
R6086 | T8952 | T8950 | advcl | reviewed,described |
R6087 | T8953 | T8952 | prep | in,reviewed |
R6088 | T8954 | T8953 | pobj | [,in |
R6089 | T8955 | T8956 | nummod | 33,] |
R6090 | T8956 | T8954 | appos | ],[ |
R6091 | T8957 | T8954 | punct | ),[ |
R6092 | T8958 | T8950 | punct | .,described |
R6093 | T8959 | T8960 | det | These,proteins |
R6094 | T8960 | T8963 | nsubjpass | proteins,discussed |
R6095 | T8961 | T8963 | auxpass | are,discussed |
R6096 | T8962 | T8963 | neg | not,discussed |
R6097 | T8963 | T8963 | ROOT | discussed,discussed |
R6098 | T8964 | T8963 | advmod | here,discussed |
R6099 | T8965 | T8963 | punct | ",",discussed |
R6100 | T8966 | T8963 | prep | since,discussed |
R6101 | T8967 | T8968 | det | a,link |
R6102 | T8968 | T8966 | pobj | link,since |
R6103 | T8969 | T8968 | prep | with,link |
R6104 | T8970 | T8971 | compound | RA,pathology |
R6105 | T8971 | T8969 | pobj | pathology,with |
R6106 | T8972 | T8978 | advcl | has,is |
R6107 | T8973 | T8976 | neg | not,"reported. Although" |
R6108 | T8974 | T8976 | advmod | yet,"reported. Although" |
R6109 | T8975 | T8976 | auxpass | been,"reported. Although" |
R6110 | T8976 | T8977 | compound | "reported. Although",IKK1 |
R6111 | T8977 | T8978 | nsubj | IKK1,is |
R6112 | T8978 | T8991 | advcl | is,mentioned |
R6113 | T8979 | T8981 | det | a,component |
R6114 | T8980 | T8981 | amod | critical,component |
R6115 | T8981 | T8978 | attr | component,is |
R6116 | T8982 | T8981 | prep | of,component |
R6117 | T8983 | T8986 | det | the,pathway |
R6118 | T8984 | T8986 | amod | non-canonical,pathway |
R6119 | T8985 | T8986 | compound | NF-κB,pathway |
R6120 | T8986 | T8982 | pobj | pathway,of |
R6121 | T8987 | T8991 | punct | ",",mentioned |
R6122 | T8988 | T8991 | nsubjpass | it,mentioned |
R6123 | T8989 | T8991 | aux | should,mentioned |
R6124 | T8990 | T8991 | auxpass | be,mentioned |
R6125 | T8991 | T8963 | advcl | mentioned,discussed |
R6126 | T8992 | T8996 | mark | that,plays |
R6127 | T8993 | T8994 | det | this,kinase |
R6128 | T8994 | T8996 | nsubj | kinase,plays |
R6129 | T8995 | T8996 | advmod | also,plays |
R6130 | T8996 | T8991 | ccomp | plays,mentioned |
R6131 | T8997 | T8999 | det | a,role |
R6132 | T8998 | T8999 | amod | prominent,role |
R6133 | T8999 | T8996 | dobj | role,plays |
R6134 | T9000 | T8999 | prep | in,role |
R6135 | T9001 | T9003 | det | the,regulation |
R6136 | T9002 | T9003 | amod | negative,regulation |
R6137 | T9003 | T9000 | pobj | regulation,in |
R6138 | T9004 | T9003 | prep | of,regulation |
R6139 | T9005 | T9006 | preconj | both,canonical |
R6140 | T9006 | T9010 | amod | canonical,pathways |
R6141 | T9007 | T9006 | cc | and,canonical |
R6142 | T9008 | T9006 | conj | noncanonical,canonical |
R6143 | T9009 | T9010 | compound | NF-κB,pathways |
R6144 | T9010 | T9004 | pobj | pathways,of |
R6145 | T9011 | T8963 | punct | .,discussed |
R6146 | T9012 | T9023 | nsubj | Macrophages,increased |
R6147 | T9013 | T9012 | prep | from,Macrophages |
R6148 | T9014 | T9015 | amod | IKK1-deficient,mice |
R6149 | T9015 | T9013 | pobj | mice,from |
R6150 | T9016 | T9015 | cc | or,mice |
R6151 | T9017 | T9018 | compound | knockin,mice |
R6152 | T9018 | T9015 | conj | mice,mice |
R6153 | T9019 | T9012 | acl | expressing,Macrophages |
R6154 | T9020 | T9022 | amod | inactive,show |
R6155 | T9021 | T9022 | compound | IKK1,show |
R6156 | T9022 | T9019 | dobj | show,expressing |
R6157 | T9023 | T9023 | ROOT | increased,increased |
R6158 | T9024 | T9023 | dobj | production,increased |
R6159 | T9025 | T9024 | prep | of,production |
R6160 | T9026 | T9027 | amod | proinflammatory,cytokines |
R6161 | T9027 | T9025 | pobj | cytokines,of |
R6162 | T9028 | T9023 | prep | as,increased |
R6163 | T9029 | T9030 | det | a,result |
R6164 | T9030 | T9028 | pobj | result,as |
R6165 | T9031 | T9030 | prep | of,result |
R6166 | T9032 | T9034 | amod | enhanced,activation |
R6167 | T9033 | T9034 | compound | IKK2,activation |
R6168 | T9034 | T9031 | pobj | activation,of |
R6169 | T9035 | T9034 | cc | and,activation |
R6170 | T9036 | T9037 | compound | IκBα,degradation |
R6171 | T9037 | T9034 | conj | degradation,activation |
R6172 | T9038 | T9040 | nmod | [,] |
R6173 | T9039 | T9040 | nummod | 34,] |
R6174 | T9040 | T9037 | appos | ],degradation |
R6175 | T9041 | T9023 | punct | .,increased |
R6176 | T9042 | T9046 | nsubjpass | IKK1,shown |
R6177 | T9043 | T9046 | aux | has,shown |
R6178 | T9044 | T9046 | advmod | also,shown |
R6179 | T9045 | T9046 | auxpass | been,shown |
R6180 | T9046 | T9046 | ROOT | shown,shown |
R6181 | T9047 | T9048 | aux | to,inhibit |
R6182 | T9048 | T9046 | advcl | inhibit,shown |
R6183 | T9049 | T9050 | amod | nuclear,NF-κB |
R6184 | T9050 | T9048 | dobj | NF-κB,inhibit |
R6185 | T9051 | T9048 | cc | and,inhibit |
R6186 | T9052 | T9053 | aux | to,downregulate |
R6187 | T9053 | T9048 | conj | downregulate,inhibit |
R6188 | T9054 | T9055 | compound | proinflammatory,signalling |
R6189 | T9055 | T9053 | dobj | signalling,downregulate |
R6190 | T9056 | T9053 | prep | by,downregulate |
R6191 | T9057 | T9056 | pcomp | phosphorylating,by |
R6192 | T9058 | T9059 | compound | STAT1,[ |
R6193 | T9059 | T9057 | dobj | [,phosphorylating |
R6194 | T9060 | T9061 | nummod | 35,] |
R6195 | T9061 | T9059 | appos | ],[ |
R6196 | T9062 | T9046 | punct | .,shown |
R6197 | T9063 | T9069 | advmod | Interestingly,demonstrated |
R6198 | T9064 | T9069 | punct | ",",demonstrated |
R6199 | T9065 | T9067 | det | a,study |
R6200 | T9066 | T9067 | amod | recent,study |
R6201 | T9067 | T9069 | nsubj | study,demonstrated |
R6202 | T9068 | T9069 | aux | has,demonstrated |
R6203 | T9069 | T9069 | ROOT | demonstrated,demonstrated |
R6204 | T9070 | T9069 | dobj | that,demonstrated |
R6205 | T9071 | T9072 | nummod | IKK1,phosphorylates |
R6206 | T9072 | T9070 | nsubj | phosphorylates,that |
R6207 | T9073 | T9072 | appos | NIK,phosphorylates |
R6208 | T9074 | T9073 | prep | in,NIK |
R6209 | T9075 | T9077 | amod | negative,regulation |
R6210 | T9076 | T9077 | compound | feedback,regulation |
R6211 | T9077 | T9074 | pobj | regulation,in |
R6212 | T9078 | T9077 | prep | of,regulation |
R6213 | T9079 | T9082 | det | the,pathway |
R6214 | T9080 | T9082 | amod | noncanonical,pathway |
R6215 | T9081 | T9082 | compound | NF-κB,pathway |
R6216 | T9082 | T9078 | pobj | pathway,of |
R6217 | T9083 | T9085 | nmod | [,] |
R6218 | T9084 | T9085 | nummod | 36,] |
R6219 | T9085 | T9082 | appos | ],pathway |
R6220 | T9086 | T9072 | punct | ",",phosphorylates |
R6221 | T9087 | T9072 | acl | supporting,phosphorylates |
R6222 | T9088 | T9089 | det | the,idea |
R6223 | T9089 | T9087 | dobj | idea,supporting |
R6224 | T9090 | T9092 | mark | that,plays |
R6225 | T9091 | T9092 | nsubj | IKK1,plays |
R6226 | T9092 | T9089 | acl | plays,idea |
R6227 | T9093 | T9094 | amod | important,roles |
R6228 | T9094 | T9092 | dobj | roles,plays |
R6229 | T9095 | T9092 | prep | in,plays |
R6230 | T9096 | T9095 | pcomp | terminating,in |
R6231 | T9097 | T9098 | preconj | both,canonical |
R6232 | T9098 | T9102 | amod | canonical,pathways |
R6233 | T9099 | T9098 | cc | and,canonical |
R6234 | T9100 | T9098 | conj | noncanonical,canonical |
R6235 | T9101 | T9102 | compound | NF-κB,pathways |
R6236 | T9102 | T9096 | dobj | pathways,terminating |
R6237 | T9103 | T9102 | prep | with,pathways |
R6238 | T9104 | T9105 | amod | possible,implications |
R6239 | T9105 | T9103 | pobj | implications,with |
R6240 | T9106 | T9105 | prep | for,implications |
R6241 | T9107 | T9109 | amod | chronic,diseases |
R6242 | T9108 | T9109 | amod | inflammatory,diseases |
R6243 | T9109 | T9106 | pobj | diseases,for |
R6244 | T9110 | T9109 | prep | like,diseases |
R6245 | T9111 | T9110 | pobj | RA,like |
R6246 | T9112 | T9069 | punct | .,demonstrated |
R7236 | T10863 | T10864 | advmod | also,known |
R7237 | T10864 | T10861 | acl | known,A20 |
R7238 | T10865 | T10864 | prep | as,known |
R7239 | T10866 | T10865 | pobj | TNFAIP3,as |
R7240 | T10867 | T10861 | punct | ),A20 |
R7241 | T10868 | T10868 | ROOT | is,is |
R7242 | T10869 | T10871 | det | a,protein |
R7243 | T10870 | T10871 | amod | ubiquitin-editing,protein |
R7244 | T10871 | T10868 | attr | protein,is |
R7245 | T10872 | T10874 | nsubj | that,regulates |
R7246 | T10873 | T10874 | advmod | negatively,regulates |
R7247 | T10874 | T10871 | relcl | regulates,protein |
R7248 | T10875 | T10877 | amod | NF-κB-dependent,expression |
R7249 | T10876 | T10877 | compound | gene,expression |
R7250 | T10877 | T10874 | dobj | expression,regulates |
R7251 | T10878 | T10874 | prep | in,regulates |
R7252 | T10879 | T10878 | pobj | response,in |
R7253 | T10880 | T10879 | prep | to,response |
R7254 | T10881 | T10883 | amod | different,stimuli |
R7255 | T10882 | T10883 | amod | immune-activating,stimuli |
R7256 | T10883 | T10880 | pobj | stimuli,to |
R7257 | T10884 | T10883 | punct | ",",stimuli |
R7258 | T10885 | T10883 | prep | including,stimuli |
R7259 | T10886 | T10885 | pobj | TNF,including |
R7260 | T10887 | T10886 | punct | ",",TNF |
R7261 | T10888 | T10886 | conj | IL-1,TNF |
R7262 | T10889 | T10888 | cc | and,IL-1 |
R7263 | T10890 | T10888 | conj | antigens,IL-1 |
R7264 | T10891 | T10883 | punct | ",",stimuli |
R7265 | T10892 | T10883 | cc | and,stimuli |
R7266 | T10893 | T10894 | det | the,triggering |
R7267 | T10894 | T10883 | conj | triggering,stimuli |
R7268 | T10895 | T10894 | prep | of,triggering |
R7269 | T10896 | T10895 | pobj | TLRs,of |
R7270 | T10897 | T10896 | cc | and,TLRs |
R7271 | T10898 | T10903 | det | the,receptor |
R7272 | T10899 | T10901 | nmod | nucleotide-binding,domain-containing |
R7273 | T10900 | T10901 | compound | oligomerisation,domain-containing |
R7274 | T10901 | T10903 | nmod | domain-containing,receptor |
R7275 | T10902 | T10903 | nummod | 2,receptor |
R7276 | T10903 | T10896 | conj | receptor,TLRs |
R7277 | T10904 | T10905 | punct | (,reviewed |
R7278 | T10905 | T10883 | acl | reviewed,stimuli |
R7279 | T10906 | T10905 | prep | in,reviewed |
R7280 | T10907 | T10906 | pobj | [,in |
R7281 | T10908 | T10909 | nummod | 37,] |
R7282 | T10909 | T10907 | appos | ],[ |
R7283 | T10910 | T10907 | punct | ),[ |
R7284 | T10911 | T10868 | punct | .,is |
R7285 | T10912 | T10914 | nsubjpass | A20,believed |
R7286 | T10913 | T10914 | auxpass | is,believed |
R7287 | T10914 | T10914 | ROOT | believed,believed |
R7288 | T10915 | T10916 | aux | to,inhibit |
R7289 | T10916 | T10914 | xcomp | inhibit,believed |
R7290 | T10917 | T10918 | amod | NF-κB,function |
R7291 | T10918 | T10916 | dobj | function,inhibit |
R7292 | T10919 | T10916 | prep | by,inhibit |
R7293 | T10920 | T10919 | pcomp | deubiquitinating,by |
R7294 | T10921 | T10924 | amod | specific,molecules |
R7295 | T10922 | T10923 | npadvmod | NF-κB,signalling |
R7296 | T10923 | T10924 | amod | signalling,molecules |
R7297 | T10924 | T10920 | dobj | molecules,deubiquitinating |
R7298 | T10925 | T10924 | punct | ",",molecules |
R7299 | T10926 | T10927 | amod | such,as |
R7300 | T10927 | T10924 | prep | as,molecules |
R7301 | T10928 | T10927 | pobj | RIP1,as |
R7302 | T10929 | T10928 | punct | ",",RIP1 |
R7303 | T10930 | T10928 | conj | RIP2,RIP1 |
R7304 | T10931 | T10930 | punct | ",",RIP2 |
R7305 | T10932 | T10930 | conj | TRAF6,RIP2 |
R7306 | T10933 | T10932 | cc | and,TRAF6 |
R7307 | T10934 | T10932 | conj | MALT1,TRAF6 |
R7308 | T10935 | T10928 | punct | ",",RIP1 |
R7309 | T10936 | T10937 | nsubj | which,disrupts |
R7310 | T10937 | T10928 | relcl | disrupts,RIP1 |
R7311 | T10938 | T10940 | amod | specific,interactions |
R7312 | T10939 | T10940 | amod | protein-protein,interactions |
R7313 | T10940 | T10937 | dobj | interactions,disrupts |
R7314 | T10941 | T10943 | nmod | [,] |
R7315 | T10942 | T10943 | nummod | 38-41,] |
R7316 | T10943 | T10940 | nmod | ],interactions |
R7317 | T10944 | T10945 | punct | (,Figure |
R7318 | T10945 | T10943 | appos | Figure,] |
R7319 | T10946 | T10945 | nummod | 1,Figure |
R7320 | T10947 | T10943 | punct | ),] |
R7321 | T10948 | T10914 | punct | .,believed |
R7322 | T10949 | T10977 | advmod | Recently,described |
R7323 | T10950 | T10977 | punct | ",",described |
R7324 | T10951 | T10952 | det | the,disruption |
R7325 | T10952 | T10977 | nsubjpass | disruption,described |
R7326 | T10953 | T10952 | prep | of,disruption |
R7327 | T10954 | T10953 | pobj | interactions,of |
R7328 | T10955 | T10952 | prep | between,disruption |
R7329 | T10956 | T10959 | nummod | E2,enzymes |
R7330 | T10957 | T10959 | nmod | ubiquitin,enzymes |
R7331 | T10958 | T10959 | amod | conjugating,enzymes |
R7332 | T10959 | T10955 | pobj | enzymes,between |
R7333 | T10960 | T10959 | punct | (,enzymes |
R7334 | T10961 | T10977 | nsubjpass | Ubc13,described |
R7335 | T10962 | T10961 | cc | and,Ubc13 |
R7336 | T10963 | T10961 | conj | Ubc5hc,Ubc13 |
R7337 | T10964 | T10963 | punct | ),Ubc5hc |
R7338 | T10965 | T10961 | cc | and,Ubc13 |
R7339 | T10966 | T10968 | nummod | E3,ligases |
R7340 | T10967 | T10968 | compound | ubiquitin,ligases |
R7341 | T10968 | T10961 | conj | ligases,Ubc13 |
R7342 | T10969 | T10968 | punct | (,ligases |
R7343 | T10970 | T10968 | appos | TRAF6,ligases |
R7344 | T10971 | T10970 | punct | ",",TRAF6 |
R7345 | T10972 | T10970 | conj | TRAF2,TRAF6 |
R7346 | T10973 | T10972 | cc | and,TRAF2 |
R7347 | T10974 | T10972 | conj | cIAP1/2,TRAF2 |
R7348 | T10975 | T10968 | punct | ),ligases |
R7349 | T10976 | T10977 | auxpass | were,described |
R7350 | T10977 | T10977 | ROOT | described,described |
R7351 | T10978 | T10977 | prep | as,described |
R7352 | T10979 | T10981 | det | another,mechanism |
R7353 | T10980 | T10981 | amod | important,mechanism |
R7354 | T10981 | T10978 | pobj | mechanism,as |
R7355 | T10982 | T10981 | acl | used,mechanism |
R7356 | T10983 | T10982 | agent | by,used |
R7357 | T10984 | T10983 | pobj | A20,by |
R7358 | T10985 | T10981 | prep | to,mechanism |
R7359 | T10986 | T10985 | pobj | downregulate,to |
R7360 | T10987 | T10988 | npadvmod | NF-κB,signalling |
R7361 | T10988 | T10986 | amod | signalling,downregulate |
R7362 | T10989 | T10991 | nmod | [,] |
R7363 | T10990 | T10991 | nummod | 42,] |
R7364 | T10991 | T10988 | dobj | ],signalling |
R7365 | T10992 | T10977 | punct | .,described |
R7366 | T10993 | T10994 | det | The,association |
R7367 | T10994 | T11000 | nsubj | association,requires |
R7368 | T10995 | T10994 | prep | of,association |
R7369 | T10996 | T10995 | pobj | A20,of |
R7370 | T10997 | T10994 | prep | with,association |
R7371 | T10998 | T10999 | poss | its,targets |
R7372 | T10999 | T10997 | pobj | targets,with |
R7373 | T11000 | T11000 | ROOT | requires,requires |
R7374 | T11001 | T11004 | amod | specific,proteins |
R7375 | T11002 | T11004 | amod | ubiquitin-binding,proteins |
R7376 | T11003 | T11004 | compound | adaptor,proteins |
R7377 | T11004 | T11000 | dobj | proteins,requires |
R7378 | T11005 | T11004 | punct | ",",proteins |
R7379 | T11006 | T11004 | prep | including,proteins |
R7380 | T11007 | T11008 | amod | A20-binding,inhibitor |
R7381 | T11008 | T11006 | pobj | inhibitor,including |
R7382 | T11009 | T11008 | prep | of,inhibitor |
R7383 | T11010 | T11009 | pobj | NF-κB,of |
R7384 | T11011 | T11010 | punct | (,NF-κB |
R7385 | T11012 | T11010 | appos | ABIN,NF-κB |
R7386 | T11013 | T11010 | punct | ),NF-κB |
R7387 | T11014 | T11010 | nummod | 1,NF-κB |
R7388 | T11015 | T11008 | cc | and,inhibitor |
R7389 | T11016 | T11017 | amod | Tax1-binding,protein |
R7390 | T11017 | T11008 | conj | protein,inhibitor |
R7391 | T11018 | T11019 | nummod | 1,[ |
R7392 | T11019 | T11021 | compound | [,] |
R7393 | T11020 | T11021 | compound | 43-46,] |
R7394 | T11021 | T11004 | appos | ],proteins |
R7395 | T11022 | T11000 | punct | .,requires |
R7396 | T11023 | T11033 | advmod | Next,is |
R7397 | T11024 | T11023 | prep | to,Next |
R7398 | T11025 | T11026 | poss | its,role |
R7399 | T11026 | T11024 | pobj | role,to |
R7400 | T11027 | T11026 | prep | in,role |
R7401 | T11028 | T11027 | pcomp | suppressing,in |
R7402 | T11029 | T11030 | amod | NF-κB,activation |
R7403 | T11030 | T11028 | dobj | activation,suppressing |
R7404 | T11031 | T11033 | punct | ",",is |
R7405 | T11032 | T11033 | nsubj | A20,is |
R7406 | T11033 | T11033 | ROOT | is,is |
R7407 | T11034 | T11033 | advmod | also,is |
R7408 | T11035 | T11037 | det | a,inhibitor |
R7409 | T11036 | T11037 | amod | strong,inhibitor |
R7410 | T11037 | T11033 | attr | inhibitor,is |
R7411 | T11038 | T11037 | prep | of,inhibitor |
R7412 | T11039 | T11038 | pobj | apoptosis,of |
R7413 | T11040 | T11037 | punct | ",",inhibitor |
R7414 | T11041 | T11042 | advmod | at,least |
R7415 | T11042 | T11043 | advmod | least,in |
R7416 | T11043 | T11037 | prep | in,inhibitor |
R7417 | T11044 | T11046 | det | some,types |
R7418 | T11045 | T11046 | compound | cell,types |
R7419 | T11046 | T11043 | pobj | types,in |
R7420 | T11047 | T11033 | punct | .,is |
R7421 | T11048 | T11049 | det | The,mechanisms |
R7422 | T11049 | T11059 | nsubj | mechanisms,are |
R7423 | T11050 | T11053 | prep | by,regulates |
R7424 | T11051 | T11050 | pobj | which,by |
R7425 | T11052 | T11053 | nsubj | A20,regulates |
R7426 | T11053 | T11049 | relcl | regulates,mechanisms |
R7427 | T11054 | T11055 | amod | apoptotic,signalling |
R7428 | T11055 | T11053 | dobj | signalling,regulates |
R7429 | T11056 | T11053 | punct | ",",regulates |
R7430 | T11057 | T11059 | advmod | however,are |
R7431 | T11058 | T11059 | punct | ",",are |
R7432 | T11059 | T11059 | ROOT | are,are |
R7433 | T11060 | T11059 | advmod | still,are |
R7434 | T11061 | T11059 | acomp | elusive,are |
R7435 | T11062 | T11059 | punct | .,are |
R7436 | T11063 | T11064 | amod | A20-deficient,mice |
R7437 | T11064 | T11066 | nsubj | mice,develop |
R7438 | T11065 | T11066 | advmod | spontaneously,develop |
R7439 | T11066 | T11066 | ROOT | develop,develop |
R7440 | T11067 | T11068 | amod | multiorgan,inflammation |
R7441 | T11068 | T11066 | dobj | inflammation,develop |
R7442 | T11069 | T11068 | cc | and,inflammation |
R7443 | T11070 | T11068 | conj | cachexia,inflammation |
R7444 | T11071 | T11070 | cc | and,cachexia |
R7445 | T11072 | T11066 | conj | die,develop |
R7446 | T11073 | T11072 | prep | within,die |
R7447 | T11074 | T11075 | nummod | 2,weeks |
R7448 | T11075 | T11073 | pobj | weeks,within |
R7449 | T11076 | T11075 | prep | of,weeks |
R7450 | T11077 | T11076 | pobj | birth,of |
R7451 | T11078 | T11072 | punct | ",",die |
R7452 | T11079 | T11072 | advcl | illustrating,die |
R7453 | T11080 | T11083 | det | the,function |
R7454 | T11081 | T11083 | amod | potent,function |
R7455 | T11082 | T11083 | amod | anti-inflammatory,function |
R7456 | T11083 | T11079 | dobj | function,illustrating |
R7457 | T11084 | T11083 | prep | of,function |
R7458 | T11085 | T11086 | det | this,molecule |
R7459 | T11086 | T11084 | pobj | molecule,of |
R7460 | T11087 | T11089 | nmod | [,] |
R7461 | T11088 | T11089 | nummod | 46,] |
R7462 | T11089 | T11083 | appos | ],function |
R7463 | T11090 | T11066 | punct | .,develop |
R7464 | T11091 | T11092 | amod | A20-deficient,cells |
R7465 | T11092 | T11093 | nsubj | cells,are |
R7466 | T11093 | T11093 | ROOT | are,are |
R7467 | T11094 | T11093 | advmod | also,are |
R7468 | T11095 | T11096 | advmod | more,susceptible |
R7469 | T11096 | T11093 | acomp | susceptible,are |
R7470 | T11097 | T11096 | prep | to,susceptible |
R7471 | T11098 | T11099 | amod | TNF-mediated,apoptosis |
R7472 | T11099 | T11097 | pobj | apoptosis,to |
R7473 | T11100 | T11093 | punct | ",",are |
R7474 | T11101 | T11093 | advcl | confirming,are |
R7475 | T11102 | T11103 | poss | its,role |
R7476 | T11103 | T11101 | dobj | role,confirming |
R7477 | T11104 | T11103 | prep | as,role |
R7478 | T11105 | T11107 | det | an,protein |
R7479 | T11106 | T11107 | amod | antiapoptotic,protein |
R7480 | T11107 | T11104 | pobj | protein,as |
R7481 | T11108 | T11093 | punct | .,are |
R7482 | T11109 | T11111 | nsubj | We,showed |
R7483 | T11110 | T11111 | advmod | recently,showed |
R7484 | T11111 | T11111 | ROOT | showed,showed |
R7485 | T11112 | T11121 | mark | that,exhibit |
R7486 | T11113 | T11121 | nsubj | mice,exhibit |
R7487 | T11114 | T11115 | advmod | specifically,lacking |
R7488 | T11115 | T11113 | acl | lacking,mice |
R7489 | T11116 | T11115 | dobj | A20,lacking |
R7490 | T11117 | T11115 | prep | in,lacking |
R7491 | T11118 | T11120 | amod | intestinal,cells |
R7492 | T11119 | T11120 | amod | epithelial,cells |
R7493 | T11120 | T11117 | pobj | cells,in |
R7494 | T11121 | T11111 | ccomp | exhibit,showed |
R7495 | T11122 | T11123 | amod | increased,susceptibility |
R7496 | T11123 | T11121 | dobj | susceptibility,exhibit |
R7497 | T11124 | T11121 | prep | to,exhibit |
R7498 | T11125 | T11126 | amod | experimental,colitis |
R7499 | T11126 | T11124 | pobj | colitis,to |
R7500 | T11127 | T11126 | amod | due,colitis |
R7501 | T11128 | T11127 | pcomp | to,due |
R7502 | T11129 | T11130 | det | the,hypersensitivity |
R7503 | T11130 | T11128 | pobj | hypersensitivity,to |
R7504 | T11131 | T11130 | prep | of,hypersensitivity |
R7505 | T11132 | T11135 | poss | their,cells |
R7506 | T11133 | T11135 | amod | intestinal,cells |
R7507 | T11134 | T11135 | amod | epithelial,cells |
R7508 | T11135 | T11131 | pobj | cells,of |
R7509 | T11136 | T11127 | pcomp | to,due |
R7510 | T11137 | T11138 | amod | TNF-induced,apoptosis |
R7511 | T11138 | T11136 | pobj | apoptosis,to |
R7512 | T11139 | T11121 | punct | ",",exhibit |
R7513 | T11140 | T11121 | advcl | confirming,exhibit |
R7514 | T11141 | T11140 | dobj | A20,confirming |
R7515 | T11142 | T11140 | prep | as,confirming |
R7516 | T11143 | T11146 | det | a,protein |
R7517 | T11144 | T11146 | amod | major,protein |
R7518 | T11145 | T11146 | amod | antiapoptotic,protein |
R7519 | T11146 | T11142 | pobj | protein,as |
R7520 | T11147 | T11146 | prep | in,protein |
R7521 | T11148 | T11151 | det | the,[ |
R7522 | T11149 | T11150 | amod | intestinal,epithelium |
R7523 | T11150 | T11151 | compound | epithelium,[ |
R7524 | T11151 | T11147 | pobj | [,in |
R7525 | T11152 | T11153 | nummod | 47,] |
R7526 | T11153 | T11151 | appos | ],[ |
R7527 | T11154 | T11111 | punct | .,showed |
R7528 | T11155 | T11157 | nummod | Two,studies |
R7529 | T11156 | T11157 | amod | independent,studies |
R7530 | T11157 | T11158 | nsubj | studies,showed |
R7531 | T11158 | T11158 | ROOT | showed,showed |
R7532 | T11159 | T11166 | mark | that,develop |
R7533 | T11160 | T11166 | nsubj | mice,develop |
R7534 | T11161 | T11160 | acl | lacking,mice |
R7535 | T11162 | T11161 | dobj | A20,lacking |
R7536 | T11163 | T11161 | prep | in,lacking |
R7537 | T11164 | T11165 | compound | B,cells |
R7538 | T11165 | T11163 | pobj | cells,in |
R7539 | T11166 | T11158 | ccomp | develop,showed |
R7540 | T11167 | T11166 | dobj | autoimmunity,develop |
R7541 | T11168 | T11166 | prep | due,develop |
R7542 | T11169 | T11168 | pcomp | to,due |
R7543 | T11170 | T11172 | amod | hyperactive,responses |
R7544 | T11171 | T11172 | compound | NF-κB,responses |
R7545 | T11172 | T11169 | pobj | responses,to |
R7546 | T11173 | T11172 | prep | in,responses |
R7547 | T11174 | T11175 | compound | B,cells |
R7548 | T11175 | T11173 | pobj | cells,in |
R7549 | T11176 | T11175 | acl | leading,cells |
R7550 | T11177 | T11176 | prep | to,leading |
R7551 | T11178 | T11180 | amod | unrestricted,survival |
R7552 | T11179 | T11180 | compound | B-cell,survival |
R7553 | T11180 | T11177 | pobj | survival,to |
R7554 | T11181 | T11183 | nmod | [,] |
R7555 | T11182 | T11183 | nummod | "48,49",] |
R7556 | T11183 | T11168 | pobj | ],due |
R7557 | T11184 | T11158 | punct | .,showed |
R7558 | T11185 | T11186 | nummod | A20,expression |
R7559 | T11186 | T11189 | nsubjpass | expression,observed |
R7560 | T11187 | T11189 | aux | has,observed |
R7561 | T11188 | T11189 | auxpass | been,observed |
R7562 | T11189 | T11189 | ROOT | observed,observed |
R7563 | T11190 | T11189 | prep | in,observed |
R7564 | T11191 | T11193 | amod | several,types |
R7565 | T11192 | T11193 | compound | cell,types |
R7566 | T11193 | T11190 | pobj | types,in |
R7567 | T11194 | T11195 | nsubj | that,play |
R7568 | T11195 | T11193 | relcl | play,types |
R7569 | T11196 | T11197 | amod | important,roles |
R7570 | T11197 | T11195 | dobj | roles,play |
R7571 | T11198 | T11195 | prep | in,play |
R7572 | T11199 | T11200 | det | the,pathophysiology |
R7573 | T11200 | T11198 | pobj | pathophysiology,in |
R7574 | T11201 | T11200 | prep | of,pathophysiology |
R7575 | T11202 | T11201 | pobj | RA,of |
R7576 | T11203 | T11195 | punct | ",",play |
R7577 | T11204 | T11205 | amod | such,as |
R7578 | T11205 | T11193 | prep | as,types |
R7579 | T11206 | T11205 | pobj | fibroblasts,as |
R7580 | T11207 | T11206 | punct | ",",fibroblasts |
R7581 | T11208 | T11206 | conj | synoviocytes,fibroblasts |
R7582 | T11209 | T11208 | cc | and,synoviocytes |
R7583 | T11210 | T11208 | conj | lymphocytes,synoviocytes |
R7584 | T11211 | T11189 | punct | .,observed |
R7585 | T11212 | T11216 | advmod | Interestingly,is |
R7586 | T11213 | T11216 | punct | ",",is |
R7587 | T11214 | T11215 | compound | A20,expression |
R7588 | T11215 | T11216 | nsubj | expression,is |
R7589 | T11216 | T11216 | ROOT | is,is |
R7590 | T11217 | T11218 | nsubjpass | itself,regulated |
R7591 | T11218 | T11216 | ccomp | regulated,is |
R7592 | T11219 | T11218 | agent | by,regulated |
R7593 | T11220 | T11221 | compound | NF-κB,[ |
R7594 | T11221 | T11223 | nmod | [,] |
R7595 | T11222 | T11223 | nummod | 50,] |
R7596 | T11223 | T11219 | pobj | ],by |
R7597 | T11224 | T11216 | punct | ",",is |
R7598 | T11225 | T11216 | advcl | implicating,is |
R7599 | T11226 | T11225 | dobj | A20,implicating |
R7600 | T11227 | T11225 | prep | in,implicating |
R7601 | T11228 | T11231 | det | the,regulation |
R7602 | T11229 | T11231 | amod | negative,regulation |
R7603 | T11230 | T11231 | compound | feedback,regulation |
R7604 | T11231 | T11227 | pobj | regulation,in |
R7605 | T11232 | T11231 | prep | of,regulation |
R7606 | T11233 | T11234 | amod | NF-κB,signalling |
R7607 | T11234 | T11232 | pobj | signalling,of |
R7608 | T11235 | T11216 | punct | .,is |
R7609 | T11236 | T11245 | advmod | Recently,shown |
R7610 | T11237 | T11245 | punct | ",",shown |
R7611 | T11238 | T11239 | amod | intra-articular,injection |
R7612 | T11239 | T11245 | nsubjpass | injection,shown |
R7613 | T11240 | T11239 | prep | of,injection |
R7614 | T11241 | T11243 | det | an,adenovirus |
R7615 | T11242 | T11243 | amod | A20-expressing,adenovirus |
R7616 | T11243 | T11240 | pobj | adenovirus,of |
R7617 | T11244 | T11245 | auxpass | was,shown |
R7618 | T11245 | T11245 | ROOT | shown,shown |
R7619 | T11246 | T11247 | aux | to,reduce |
R7620 | T11247 | T11245 | xcomp | reduce,shown |
R7621 | T11248 | T11249 | det | the,severity |
R7622 | T11249 | T11247 | dobj | severity,reduce |
R7623 | T11250 | T11249 | prep | of,severity |
R7624 | T11251 | T11252 | amod | synovial,inflammation |
R7625 | T11252 | T11250 | pobj | inflammation,of |
R7626 | T11253 | T11252 | cc | and,inflammation |
R7627 | T11254 | T11255 | amod | joint,destruction |
R7628 | T11255 | T11252 | conj | destruction,inflammation |
R7629 | T11256 | T11247 | prep | in,reduce |
R7630 | T11257 | T11259 | det | a,model |
R7631 | T11258 | T11259 | compound | mouse,model |
R7632 | T11259 | T11256 | pobj | model,in |
R7633 | T11260 | T11259 | prep | of,model |
R7634 | T11261 | T11262 | amod | collagen-induced,arthritis |
R7635 | T11262 | T11260 | pobj | arthritis,of |
R7636 | T11263 | T11247 | punct | ",",reduce |
R7637 | T11264 | T11265 | advmod | even,in |
R7638 | T11265 | T11247 | prep | in,reduce |
R7639 | T11266 | T11267 | amod | untreated,joints |
R7640 | T11267 | T11265 | pobj | joints,in |
R7641 | T11268 | T11247 | punct | ",",reduce |
R7642 | T11269 | T11247 | prep | in,reduce |
R7643 | T11270 | T11275 | preconj | both,setting |
R7644 | T11271 | T11275 | det | a,setting |
R7645 | T11272 | T11275 | nmod | prophylactic,setting |
R7646 | T11273 | T11272 | cc | and,prophylactic |
R7647 | T11274 | T11275 | amod | therapeutic,setting |
R7648 | T11275 | T11269 | pobj | setting,in |
R7649 | T11276 | T11245 | punct | .,shown |
R7650 | T11277 | T11278 | nummod | A20,expression |
R7651 | T11278 | T11283 | nsubjpass | expression,associated |
R7652 | T11279 | T11278 | prep | in,expression |
R7653 | T11280 | T11281 | amod | synovial,tissue |
R7654 | T11281 | T11279 | pobj | tissue,in |
R7655 | T11282 | T11283 | auxpass | was,associated |
R7656 | T11283 | T11283 | ROOT | associated,associated |
R7657 | T11284 | T11283 | prep | with,associated |
R7658 | T11285 | T11284 | pobj | inhibition,with |
R7659 | T11286 | T11285 | prep | of,inhibition |
R7660 | T11287 | T11288 | amod | NF-κB,activity |
R7661 | T11288 | T11286 | pobj | activity,of |
R7662 | T11289 | T11283 | cc | and,associated |
R7663 | T11290 | T11291 | amod | decreased,levels |
R7664 | T11291 | T11283 | conj | levels,associated |
R7665 | T11292 | T11291 | prep | of,levels |
R7666 | T11293 | T11292 | pobj | TNF,of |
R7667 | T11294 | T11293 | punct | ",",TNF |
R7668 | T11295 | T11293 | conj | IL-1β,TNF |
R7669 | T11296 | T11295 | punct | ",",IL-1β |
R7670 | T11297 | T11295 | conj | IL-6,IL-1β |
R7671 | T11298 | T11297 | punct | ",",IL-6 |
R7672 | T11299 | T11300 | amod | soluble,RANKL |
R7673 | T11300 | T11297 | conj | RANKL,IL-6 |
R7674 | T11301 | T11300 | punct | ",",RANKL |
R7675 | T11302 | T11304 | amod | monocyte,protein |
R7676 | T11303 | T11304 | compound | chemo-attractant,protein |
R7677 | T11304 | T11300 | appos | protein,RANKL |
R7678 | T11305 | T11304 | nummod | 1,protein |
R7679 | T11306 | T11300 | punct | ",",RANKL |
R7680 | T11307 | T11300 | cc | and,RANKL |
R7681 | T11308 | T11300 | conj | IL-17,RANKL |
R7682 | T11309 | T11283 | punct | ",",associated |
R7683 | T11310 | T11283 | advcl | suggesting,associated |
R7684 | T11311 | T11313 | mark | that,induces |
R7685 | T11312 | T11313 | nsubj | A20,induces |
R7686 | T11313 | T11310 | ccomp | induces,suggesting |
R7687 | T11314 | T11316 | det | a,effect |
R7688 | T11315 | T11316 | amod | protective,effect |
R7689 | T11316 | T11313 | dobj | effect,induces |
R7690 | T11317 | T11316 | prep | in,effect |
R7691 | T11318 | T11320 | amod | collagen-induced,mice |
R7692 | T11319 | T11320 | compound | arthritis,mice |
R7693 | T11320 | T11317 | pobj | mice,in |
R7694 | T11321 | T11313 | prep | through,induces |
R7695 | T11322 | T11321 | pobj | suppression,through |
R7696 | T11323 | T11322 | prep | of,suppression |
R7697 | T11324 | T11325 | amod | NF-κB,activation |
R7698 | T11325 | T11323 | pobj | activation,of |
R7699 | T11326 | T11325 | cc | and,activation |
R7700 | T11327 | T11331 | punct | NF,expression |
R7701 | T11328 | T11329 | punct | -,κB-dependent |
R7702 | T11329 | T11331 | amod | κB-dependent,expression |
R7703 | T11330 | T11331 | compound | gene,expression |
R7704 | T11331 | T11313 | npadvmod | expression,induces |
R7705 | T11332 | T11331 | appos | [,expression |
R7706 | T11333 | T11334 | nummod | 51,] |
R7707 | T11334 | T11331 | appos | ],expression |
R7708 | T11335 | T11283 | punct | .,associated |
R7709 | T11336 | T11341 | mark | Because,known |
R7710 | T11337 | T11341 | nsubjpass | TNF,known |
R7711 | T11338 | T11337 | cc | and,TNF |
R7712 | T11339 | T11337 | conj | IL-1β,TNF |
R7713 | T11340 | T11341 | auxpass | are,known |
R7714 | T11341 | T11370 | advcl | known,explain |
R7715 | T11342 | T11343 | aux | to,mediate |
R7716 | T11343 | T11341 | xcomp | mediate,known |
R7717 | T11344 | T11343 | dobj | synovitis,mediate |
R7718 | T11345 | T11343 | punct | ",",mediate |
R7719 | T11346 | T11347 | compound | pannus,formation |
R7720 | T11347 | T11343 | conj | formation,mediate |
R7721 | T11348 | T11347 | punct | ",",formation |
R7722 | T11349 | T11347 | cc | and,formation |
R7723 | T11350 | T11347 | conj | erosion,formation |
R7724 | T11351 | T11350 | prep | of,erosion |
R7725 | T11352 | T11351 | pobj | cartilage,of |
R7726 | T11353 | T11352 | cc | and,cartilage |
R7727 | T11354 | T11352 | conj | bone,cartilage |
R7728 | T11355 | T11347 | prep | in,formation |
R7729 | T11356 | T11355 | pobj | RA,in |
R7730 | T11357 | T11370 | punct | ",",explain |
R7731 | T11358 | T11361 | det | the,levels |
R7732 | T11359 | T11361 | amod | decreased,levels |
R7733 | T11360 | T11361 | compound | serum,levels |
R7734 | T11361 | T11370 | nsubj | levels,explain |
R7735 | T11362 | T11361 | prep | of,levels |
R7736 | T11363 | T11362 | pobj | TNF,of |
R7737 | T11364 | T11363 | cc | and,TNF |
R7738 | T11365 | T11363 | conj | IL-1β,TNF |
R7739 | T11366 | T11361 | prep | in,levels |
R7740 | T11367 | T11368 | amod | A20-transduced,mice |
R7741 | T11368 | T11366 | pobj | mice,in |
R7742 | T11369 | T11370 | aux | might,explain |
R7743 | T11370 | T11370 | ROOT | explain,explain |
R7744 | T11371 | T11373 | det | the,effects |
R7745 | T11372 | T11373 | amod | beneficial,effects |
R7746 | T11373 | T11370 | dobj | effects,explain |
R7747 | T11374 | T11373 | prep | in,effects |
R7748 | T11375 | T11378 | det | the,pathological |
R7749 | T11376 | T11378 | amod | clinical,pathological |
R7750 | T11377 | T11378 | punct | ",",pathological |
R7751 | T11378 | T11374 | pobj | pathological,in |
R7752 | T11379 | T11373 | punct | ",",effects |
R7753 | T11380 | T11373 | cc | and,effects |
R7754 | T11381 | T11382 | amod | radiological,findings |
R7755 | T11382 | T11373 | conj | findings,effects |
R7756 | T11383 | T11370 | punct | .,explain |
R7757 | T11384 | T11385 | det | This,study |
R7758 | T11385 | T11387 | nsubj | study,demonstrated |
R7759 | T11386 | T11387 | advmod | also,demonstrated |
R7760 | T11387 | T11387 | ROOT | demonstrated,demonstrated |
R7761 | T11388 | T11391 | mark | that,leads |
R7762 | T11389 | T11390 | nummod | A20,overexpression |
R7763 | T11390 | T11391 | nsubj | overexpression,leads |
R7764 | T11391 | T11387 | ccomp | leads,demonstrated |
R7765 | T11392 | T11391 | prep | to,leads |
R7766 | T11393 | T11394 | det | a,decrease |
R7767 | T11394 | T11392 | pobj | decrease,to |
R7768 | T11395 | T11394 | prep | in,decrease |
R7769 | T11396 | T11397 | det | the,number |
R7770 | T11397 | T11395 | pobj | number,in |
R7771 | T11398 | T11397 | prep | of,number |
R7772 | T11399 | T11400 | amod | activated,osteoclasts |
R7773 | T11400 | T11398 | pobj | osteoclasts,of |
R7774 | T11401 | T11400 | prep | in,osteoclasts |
R7775 | T11402 | T11403 | amod | joint,tissue |
R7776 | T11403 | T11401 | pobj | tissue,in |
R7777 | T11404 | T11387 | punct | .,demonstrated |
R7778 | T11405 | T11408 | nsubj | A20,minimise |
R7779 | T11406 | T11408 | aux | might,minimise |
R7780 | T11407 | T11408 | advmod | therefore,minimise |
R7781 | T11408 | T11408 | ROOT | minimise,minimise |
R7782 | T11409 | T11410 | amod | joint,destruction |
R7783 | T11410 | T11408 | dobj | destruction,minimise |
R7784 | T11411 | T11408 | prep | through,minimise |
R7785 | T11412 | T11411 | pcomp | decreasing,through |
R7786 | T11413 | T11415 | det | the,number |
R7787 | T11414 | T11415 | amod | osteoclast,number |
R7788 | T11415 | T11412 | dobj | number,decreasing |
R7789 | T11416 | T11415 | cc | and,number |
R7790 | T11417 | T11415 | conj | activity,number |
R7791 | T11418 | T11408 | punct | .,minimise |
R7792 | T11419 | T11421 | nsubj | It,be |
R7793 | T11420 | T11421 | aux | will,be |
R7794 | T11421 | T11421 | ROOT | be,be |
R7795 | T11422 | T11421 | acomp | interesting,be |
R7796 | T11423 | T11424 | aux | to,analyse |
R7797 | T11424 | T11421 | xcomp | analyse,be |
R7798 | T11425 | T11424 | prep | in,analyse |
R7799 | T11426 | T11425 | pobj | future,in |
R7800 | T11427 | T11428 | det | the,susceptibility |
R7801 | T11428 | T11424 | dobj | susceptibility,analyse |
R7802 | T11429 | T11428 | prep | of,susceptibility |
R7803 | T11430 | T11432 | amod | conditional,mice |
R7804 | T11431 | T11432 | compound | knockout,mice |
R7805 | T11432 | T11429 | pobj | mice,of |
R7806 | T11433 | T11434 | nsubj | that,lack |
R7807 | T11434 | T11432 | relcl | lack,mice |
R7808 | T11435 | T11434 | dobj | A20,lack |
R7809 | T11436 | T11435 | prep | in,A20 |
R7810 | T11437 | T11439 | amod | specific,types |
R7811 | T11438 | T11439 | compound | cell,types |
R7812 | T11439 | T11436 | pobj | types,in |
R7813 | T11440 | T11441 | amod | such,as |
R7814 | T11441 | T11439 | prep | as,types |
R7815 | T11442 | T11443 | amod | synovial,fibroblasts |
R7816 | T11443 | T11441 | pobj | fibroblasts,as |
R7817 | T11444 | T11443 | punct | ",",fibroblasts |
R7818 | T11445 | T11443 | conj | macrophages,fibroblasts |
R7819 | T11446 | T11445 | punct | ",",macrophages |
R7820 | T11447 | T11448 | amod | dendritic,cells |
R7821 | T11448 | T11445 | conj | cells,macrophages |
R7822 | T11449 | T11445 | punct | ",",macrophages |
R7823 | T11450 | T11451 | compound | B,cells |
R7824 | T11451 | T11445 | conj | cells,macrophages |
R7825 | T11452 | T11451 | cc | or,cells |
R7826 | T11453 | T11454 | compound | T,cells |
R7827 | T11454 | T11451 | conj | cells,cells |
R7828 | T11455 | T11421 | punct | .,be |
R7829 | T11456 | T11467 | advmod | Importantly,associated |
R7830 | T11457 | T11467 | punct | ",",associated |
R7831 | T11458 | T11459 | amod | several,SNPs |
R7832 | T11459 | T11467 | nsubjpass | SNPs,associated |
R7833 | T11460 | T11459 | prep | in,SNPs |
R7834 | T11461 | T11464 | det | the,locus |
R7835 | T11462 | T11464 | amod | human,locus |
R7836 | T11463 | T11464 | compound | A20,locus |
R7837 | T11464 | T11460 | pobj | locus,in |
R7838 | T11465 | T11467 | aux | have,associated |
R7839 | T11466 | T11467 | auxpass | been,associated |
R7840 | T11467 | T11467 | ROOT | associated,associated |
R7841 | T11468 | T11467 | prep | with,associated |
R7842 | T11469 | T11470 | amod | increased,susceptibility |
R7843 | T11470 | T11468 | pobj | susceptibility,with |
R7844 | T11471 | T11470 | prep | to,susceptibility |
R7845 | T11472 | T11471 | pobj | development,to |
R7846 | T11473 | T11472 | prep | of,development |
R7847 | T11474 | T11475 | amod | autoimmune,pathologies |
R7848 | T11475 | T11473 | pobj | pathologies,of |
R7849 | T11476 | T11477 | punct | (,reviewed |
R7850 | T11477 | T11475 | acl | reviewed,pathologies |
R7851 | T11495 | T11494 | prep | in,mutations |
R7852 | T11478 | T11477 | prep | in,reviewed |
R7853 | T11496 | T11498 | det | the,locus |
R7854 | T11479 | T11478 | pobj | [,in |
R7855 | T11497 | T11498 | compound | A20,locus |
R7856 | T11498 | T11495 | pobj | locus,in |
R7857 | T11480 | T11481 | nummod | 52,] |
R7858 | T11499 | T11494 | prep | in,mutations |
R7859 | T11500 | T11502 | det | the,chromosome |
R7860 | T11481 | T11479 | appos | ],[ |
R7861 | T11501 | T11502 | amod | 6q23,chromosome |
R7862 | T11502 | T11499 | pobj | chromosome,in |
R7863 | T11503 | T11502 | cc | and,chromosome |
R7864 | T11482 | T11479 | punct | ),[ |
R7865 | T11504 | T11502 | conj | susceptibility,chromosome |
R7866 | T11505 | T11504 | prep | to,susceptibility |
R7867 | T11506 | T11507 | compound | RA,[ |
R7868 | T11483 | T11467 | punct | .,associated |
R7869 | T11507 | T11505 | pobj | [,to |
R7870 | T11508 | T11509 | nummod | 52,] |
R7871 | T11509 | T11507 | appos | ],[ |
R7872 | T11510 | T11489 | punct | .,revealed |
R7873 | T11484 | T11487 | amod | Several,studies |
R7874 | T11511 | T11517 | mark | Although,located |
R7875 | T11512 | T11514 | det | the,variants |
R7876 | T11485 | T11486 | compound | genome-wide,association |
R7877 | T11513 | T11514 | amod | identified,variants |
R7878 | T11514 | T11517 | nsubjpass | variants,located |
R7879 | T11515 | T11517 | auxpass | are,located |
R7880 | T11486 | T11487 | compound | association,studies |
R7881 | T11516 | T11517 | neg | not,located |
R7882 | T11517 | T11524 | advcl | located,thought |
R7883 | T11518 | T11517 | prep | in,located |
R7884 | T11487 | T11489 | nsubj | studies,revealed |
R7885 | T11519 | T11520 | det | a,gene |
R7886 | T11520 | T11518 | pobj | gene,in |
R7887 | T11521 | T11524 | punct | ",",thought |
R7888 | T11488 | T11489 | advmod | also,revealed |
R7889 | T11522 | T11524 | nsubjpass | they,thought |
R7890 | T11523 | T11524 | auxpass | are,thought |
R7891 | T11489 | T11489 | ROOT | revealed,revealed |
R7892 | T11524 | T11524 | ROOT | thought,thought |
R7893 | T11525 | T11526 | aux | to,influence |
R7894 | T11526 | T11524 | xcomp | influence,thought |
R7895 | T11527 | T11526 | dobj | A20,influence |
R7896 | T11490 | T11492 | det | a,association |
R7897 | T11528 | T11526 | prep | as,influence |
R7898 | T11529 | T11531 | poss | its,gene |
R7899 | T11491 | T11492 | amod | clear,association |
R7900 | T11530 | T11531 | amod | nearest,gene |
R7901 | T11531 | T11528 | pobj | gene,as |
R7902 | T11532 | T11531 | punct | (,gene |
R7903 | T11533 | T11531 | appos | ~,gene |
R7904 | T11492 | T11489 | dobj | association,revealed |
R7905 | T11534 | T11535 | nummod | 150,kb |
R7906 | T11535 | T11533 | appos | kb,~ |
R7907 | T11493 | T11492 | prep | between,association |
R7908 | T11536 | T11535 | amod | downstream,kb |
R7909 | T11537 | T11536 | prep | of,downstream |
R7910 | T11538 | T11537 | pobj | A20,of |
R7911 | T11494 | T11493 | pobj | mutations,between |
R7912 | T11539 | T11535 | punct | ),kb |
R7913 | T11540 | T11531 | punct | ",",gene |
R7914 | T11541 | T11542 | advmod | probably,by |
R7915 | T11592 | T11589 | dobj | activity,affect |
R7916 | T11542 | T11526 | prep | by,influence |
R7917 | T11543 | T11544 | det | the,presence |
R7918 | T11544 | T11542 | pobj | presence,by |
R7919 | T11545 | T11544 | prep | of,presence |
R7920 | T11593 | T11592 | cc | and,activity |
R7921 | T11546 | T11549 | amod | potential,elements |
R7922 | T11547 | T11549 | amod | regulatory,elements |
R7923 | T11548 | T11549 | compound | DNA,elements |
R7924 | T11594 | T11596 | advmod | how,cause |
R7925 | T11549 | T11545 | pobj | elements,of |
R7926 | T11550 | T11549 | prep | in,elements |
R7927 | T11551 | T11552 | det | this,region |
R7928 | T11595 | T11596 | nsubj | they,cause |
R7929 | T11552 | T11550 | pobj | region,in |
R7930 | T11553 | T11524 | punct | .,thought |
R7931 | T11554 | T11557 | mark | As,required |
R7932 | T11596 | T11601 | advcl | cause,remain |
R7933 | T11555 | T11557 | nsubjpass | A20,required |
R7934 | T11556 | T11557 | auxpass | is,required |
R7935 | T11557 | T11576 | advcl | required,reveal |
R7936 | T11558 | T11557 | prep | for,required |
R7937 | T11597 | T11596 | dobj | RA,cause |
R7938 | T11559 | T11558 | pobj | termination,for |
R7939 | T11560 | T11559 | prep | of,termination |
R7940 | T11561 | T11562 | amod | TNF-induced,signals |
R7941 | T11598 | T11601 | punct | ",",remain |
R7942 | T11562 | T11560 | pobj | signals,of |
R7943 | T11563 | T11557 | punct | ",",required |
R7944 | T11564 | T11557 | cc | and,required |
R7945 | T11565 | T11566 | nsubj | TNF,is |
R7946 | T11566 | T11557 | conj | is,required |
R7947 | T11567 | T11570 | det | the,cytokine |
R7948 | T11599 | T11601 | advmod | however,remain |
R7949 | T11568 | T11570 | amod | primary,cytokine |
R7950 | T11569 | T11570 | amod | inflammatory,cytokine |
R7951 | T11570 | T11566 | attr | cytokine,is |
R7952 | T11571 | T11570 | prep | in,cytokine |
R7953 | T11600 | T11601 | punct | ",",remain |
R7954 | T11572 | T11571 | pobj | RA,in |
R7955 | T11573 | T11576 | punct | ",",reveal |
R7956 | T11574 | T11575 | det | these,findings |
R7957 | T11575 | T11576 | nsubj | findings,reveal |
R7958 | T11601 | T11601 | ROOT | remain,remain |
R7959 | T11576 | T11576 | ROOT | reveal,reveal |
R7960 | T11577 | T11576 | dobj | A20,reveal |
R7961 | T11602 | T11601 | acomp | unclear,remain |
R7962 | T11578 | T11576 | prep | as,reveal |
R7963 | T11579 | T11582 | det | a,locus |
R7964 | T11580 | T11581 | compound | candidate,susceptibility |
R7965 | T11603 | T11601 | punct | .,remain |
R7966 | T11581 | T11582 | compound | susceptibility,locus |
R7967 | T11582 | T11578 | pobj | locus,as |
R7968 | T11583 | T11582 | prep | for,locus |
R7969 | T11604 | T11610 | advmod | Recently,evaluated |
R7970 | T11584 | T11583 | pobj | RA,for |
R7971 | T11585 | T11576 | punct | .,reveal |
R7972 | T11586 | T11589 | advmod | How,affect |
R7973 | T11587 | T11588 | det | these,variants |
R7974 | T11605 | T11610 | punct | ",",evaluated |
R7975 | T11588 | T11589 | nsubj | variants,affect |
R7976 | T11589 | T11601 | advcl | affect,remain |
R7977 | T11590 | T11592 | amod | normal,activity |
R7978 | T11606 | T11610 | nsubj | Elsby,evaluated |
R7979 | T11591 | T11592 | amod | A20,activity |
R7980 | T11607 | T11606 | cc | and,Elsby |
R7981 | T11608 | T11606 | conj | colleagues,Elsby |
R7982 | T11609 | T11610 | advmod | functionally,evaluated |
R7983 | T11610 | T11610 | ROOT | evaluated,evaluated |
R7984 | T11611 | T11610 | prep | in,evaluated |
R7985 | T11612 | T11611 | pobj | vitro,in |
R7986 | T11613 | T11615 | det | the,ability |
R7987 | T11614 | T11615 | amod | regulatory,ability |
R7988 | T11615 | T11610 | dobj | ability,evaluated |
R7989 | T11616 | T11615 | prep | of,ability |
R7990 | T11617 | T11619 | amod | RA-associated,variants |
R7991 | T11618 | T11619 | compound | SNP,variants |
R7992 | T11619 | T11616 | pobj | variants,of |
R7993 | T11620 | T11615 | prep | on,ability |
R7994 | T11621 | T11623 | compound | A20,activity |
R7995 | T11622 | T11623 | compound | promoter,activity |
R7996 | T11623 | T11620 | pobj | activity,on |
R7997 | T11624 | T11610 | punct | ",",evaluated |
R7998 | T11625 | T11610 | cc | and,evaluated |
R7999 | T11626 | T11627 | aux | could,show |
R8000 | T11627 | T11610 | conj | show,evaluated |
R8001 | T11628 | T11630 | amod | repressed,transcription |
R8002 | T11629 | T11630 | compound | A20,transcription |
R8003 | T11630 | T11627 | dobj | transcription,show |
R8004 | T11631 | T11630 | prep | for,transcription |
R8005 | T11632 | T11631 | pobj | some,for |
R8006 | T11633 | T11632 | prep | of,some |
R8007 | T11634 | T11635 | det | the,SNPs |
R8008 | T11635 | T11633 | pobj | SNPs,of |
R8009 | T11636 | T11627 | conj | investigated,show |
R8010 | T11637 | T11639 | nmod | [,] |
R8011 | T11638 | T11639 | nummod | 53,] |
R8012 | T11639 | T11636 | dobj | ],investigated |
R8013 | T11640 | T11610 | punct | .,evaluated |
R8014 | T11641 | T11643 | nsubj | It,be |
R8015 | T11642 | T11643 | aux | will,be |
R8016 | T11643 | T11643 | ROOT | be,be |
R8017 | T11644 | T11643 | prep | of,be |
R8018 | T11645 | T11644 | pobj | interest,of |
R8019 | T11646 | T11647 | aux | to,identify |
R8020 | T11647 | T11643 | advcl | identify,be |
R8021 | T11648 | T11651 | det | the,variants |
R8022 | T11649 | T11651 | amod | actual,variants |
R8023 | T11650 | T11651 | amod | causal,variants |
R8024 | T11651 | T11647 | dobj | variants,identify |
R8026 | T11652 | T11647 | cc | and,identify |
R8027 | T11653 | T11654 | aux | to,elucidate |
R8029 | T11654 | T11647 | conj | elucidate,identify |
R8031 | T11655 | T11657 | det | the,consequences |
R8033 | T11656 | T11657 | amod | functional,consequences |
R8034 | T11657 | T11654 | dobj | consequences,elucidate |
R8035 | T11658 | T11657 | prep | of,consequences |
R8037 | T11659 | T11660 | det | these,variants |
R8039 | T11660 | T11658 | pobj | variants,of |
R8041 | T11661 | T11643 | punct | .,be |
R8043 | T11662 | T11682 | prep | In,be |
R8044 | T11663 | T11664 | det | this,context |
R8046 | T11664 | T11662 | pobj | context,In |
R8048 | T11665 | T11682 | punct | ",",be |
R8052 | T11666 | T11667 | nmod | knockin,mice |
R8055 | T11667 | T11682 | nsubj | mice,be |
R8063 | T11668 | T11667 | prep | for,mice |
R8067 | T11669 | T11672 | det | the,SNPs |
R8070 | T11670 | T11672 | amod | corresponding,SNPs |
R8072 | T11671 | T11672 | compound | A20,SNPs |
R8075 | T11672 | T11668 | pobj | SNPs,for |
R8077 | T11673 | T11672 | punct | ",",SNPs |
R8080 | T11674 | T11672 | acl | combined,SNPs |
R8081 | T11675 | T11674 | prep | with,combined |
R8083 | T11676 | T11677 | compound | mouse,models |
R8086 | T11677 | T11675 | pobj | models,with |
R8087 | T11678 | T11677 | prep | for,models |
R8088 | T11679 | T11678 | pobj | RA,for |
R8089 | T11680 | T11682 | punct | ",",be |
R8090 | T11681 | T11682 | aux | will,be |
R8091 | T11682 | T11682 | ROOT | be,be |
R8092 | T11683 | T11684 | advmod | very,valuable |
R8094 | T11684 | T11685 | amod | valuable,tools |
R8098 | T11685 | T11682 | attr | tools,be |
R8099 | T11686 | T11682 | punct | .,be |
R8766 | T13215 | T13235 | nsubjpass | inhibitors,identified |
R8767 | T13216 | T13215 | prep | of,inhibitors |
R8768 | T13217 | T13218 | compound | NF-κB,ABIN-1 |
R8769 | T13218 | T13216 | pobj | ABIN-1,of |
R8770 | T13219 | T13218 | punct | ",",ABIN-1 |
R8771 | T13220 | T13218 | conj | ABIN-2,ABIN-1 |
R8772 | T13221 | T13220 | cc | and,ABIN-2 |
R8773 | T13222 | T13220 | conj | ABIN-3,ABIN-2 |
R8774 | T13223 | T13225 | punct | (,known |
R8775 | T13224 | T13225 | advmod | also,known |
R8776 | T13225 | T13215 | acl | known,inhibitors |
R8777 | T13226 | T13225 | prep | as,known |
R8778 | T13227 | T13226 | pobj | TNIP-1,as |
R8779 | T13228 | T13227 | punct | ",",TNIP-1 |
R8780 | T13229 | T13227 | appos | TNIP-2,TNIP-1 |
R8781 | T13230 | T13225 | punct | ",",known |
R8782 | T13231 | T13225 | cc | and,known |
R8783 | T13232 | T13215 | appos | TNIP-3,inhibitors |
R8784 | T13233 | T13215 | punct | ),inhibitors |
R8785 | T13234 | T13235 | auxpass | were,identified |
R8786 | T13235 | T13235 | ROOT | identified,identified |
R8787 | T13236 | T13235 | prep | as,identified |
R8788 | T13237 | T13238 | advmod | ubiquitously,expressed |
R8789 | T13238 | T13239 | amod | expressed,A20 |
R8790 | T13239 | T13240 | nsubj | A20,interacting |
R8791 | T13240 | T13236 | pcomp | interacting,as |
R8792 | T13241 | T13240 | dobj | proteins,interacting |
R8793 | T13242 | T13235 | cc | and,identified |
R8794 | T13243 | T13244 | auxpass | were,shown |
R8795 | T13244 | T13235 | conj | shown,identified |
R8796 | T13245 | T13246 | aux | to,inhibit |
R8797 | T13246 | T13244 | xcomp | inhibit,shown |
R8798 | T13247 | T13248 | amod | NF-κB,activation |
R8799 | T13248 | T13246 | dobj | activation,inhibit |
R8800 | T13249 | T13248 | prep | by,activation |
R8801 | T13250 | T13249 | pobj | TNF,by |
R8802 | T13251 | T13250 | cc | and,TNF |
R8803 | T13252 | T13255 | amod | several,stimuli |
R8804 | T13253 | T13255 | amod | other,stimuli |
R8805 | T13254 | T13255 | amod | inflammatory,stimuli |
R8806 | T13255 | T13250 | conj | stimuli,TNF |
R8807 | T13256 | T13255 | prep | upon,stimuli |
R8808 | T13257 | T13256 | pobj | overexpression,upon |
R8809 | T13258 | T13235 | punct | .,identified |
R8810 | T13259 | T13261 | mark | Because,contain |
R8811 | T13260 | T13261 | nsubj | ABINs,contain |
R8812 | T13261 | T13270 | advcl | contain,proposed |
R8813 | T13262 | T13265 | det | a,motif |
R8814 | T13263 | T13265 | amod | specific,motif |
R8815 | T13264 | T13265 | amod | ubiquitin-binding,motif |
R8816 | T13265 | T13261 | dobj | motif,contain |
R8817 | T13266 | T13270 | punct | ",",proposed |
R8818 | T13267 | T13270 | nsubjpass | they,proposed |
R8819 | T13268 | T13270 | aux | have,proposed |
R8820 | T13269 | T13270 | auxpass | been,proposed |
R8821 | T13270 | T13270 | ROOT | proposed,proposed |
R8822 | T13271 | T13272 | aux | to,target |
R8823 | T13272 | T13270 | xcomp | target,proposed |
R8824 | T13273 | T13272 | dobj | A20,target |
R8825 | T13274 | T13272 | prep | to,target |
R8826 | T13275 | T13276 | amod | polyubiquitinated,substrates |
R8827 | T13276 | T13274 | pobj | substrates,to |
R8828 | T13277 | T13279 | compound | [,] |
R8829 | T13278 | T13279 | compound | "43,44",] |
R8830 | T13279 | T13276 | appos | ],substrates |
R8831 | T13280 | T13270 | punct | .,proposed |
R8832 | T13281 | T13288 | amod | Similar,expression |
R8833 | T13282 | T13281 | prep | to,Similar |
R8834 | T13283 | T13282 | pobj | A20,to |
R8835 | T13284 | T13283 | punct | ",",A20 |
R8836 | T13285 | T13283 | conj | ABIN-1,A20 |
R8837 | T13286 | T13285 | cc | and,ABIN-1 |
R8838 | T13287 | T13288 | compound | ABIN-3,expression |
R8839 | T13288 | T13289 | nsubj | expression,is |
R8840 | T13289 | T13289 | ROOT | is,is |
R8841 | T13290 | T13291 | advmod | NF-κB,dependent |
R8842 | T13291 | T13289 | acomp | dependent,is |
R8843 | T13292 | T13289 | punct | ",",is |
R8844 | T13293 | T13289 | advcl | implicating,is |
R8845 | T13294 | T13296 | det | a,role |
R8846 | T13295 | T13296 | amod | potential,role |
R8847 | T13296 | T13293 | dobj | role,implicating |
R8848 | T13297 | T13296 | prep | for,role |
R8849 | T13298 | T13300 | det | the,complex |
R8850 | T13299 | T13300 | compound | A20/ABIN,complex |
R8851 | T13300 | T13297 | pobj | complex,for |
R8852 | T13301 | T13300 | prep | in,complex |
R8853 | T13302 | T13305 | det | the,regulation |
R8854 | T13303 | T13305 | amod | negative,regulation |
R8855 | T13304 | T13305 | compound | feedback,regulation |
R8856 | T13305 | T13301 | pobj | regulation,in |
R8857 | T13306 | T13305 | prep | of,regulation |
R8858 | T13307 | T13308 | amod | NF-κB,activation |
R8859 | T13308 | T13306 | pobj | activation,of |
R8860 | T13309 | T13310 | punct | (,reviewed |
R8861 | T13310 | T13296 | acl | reviewed,role |
R8862 | T13311 | T13310 | prep | in,reviewed |
R8863 | T13312 | T13311 | pobj | [,in |
R8864 | T13313 | T13314 | nummod | 54,] |
R8865 | T13314 | T13312 | appos | ],[ |
R8866 | T13315 | T13312 | punct | ),[ |
R8867 | T13316 | T13289 | punct | .,is |
R8868 | T13317 | T13324 | advmod | Unexpectedly,exhibit |
R8869 | T13318 | T13324 | punct | ",",exhibit |
R8870 | T13319 | T13320 | preconj | both,ABIN-1-deficient |
R8871 | T13320 | T13324 | amod | ABIN-1-deficient,exhibit |
R8872 | T13321 | T13320 | cc | and,ABIN-1-deficient |
R8873 | T13322 | T13320 | conj | ABIN-2-deficient,ABIN-1-deficient |
R8874 | T13323 | T13324 | nsubj | mice,exhibit |
R8875 | T13324 | T13324 | ROOT | exhibit,exhibit |
R8876 | T13325 | T13326 | advmod | only,slightly |
R8877 | T13326 | T13327 | advmod | slightly,increased |
R8878 | T13327 | T13331 | amod | increased,responses |
R8879 | T13328 | T13327 | cc | or,increased |
R8880 | T13329 | T13331 | amod | normal,responses |
R8881 | T13330 | T13331 | compound | NF-κB,responses |
R8882 | T13331 | T13324 | dobj | responses,exhibit |
R8883 | T13332 | T13331 | punct | ",",responses |
R8884 | T13333 | T13331 | advmod | respectively,responses |
R8885 | T13334 | T13331 | punct | ",",responses |
R8886 | T13335 | T13336 | advmod | possibly,reflecting |
R8887 | T13336 | T13324 | advcl | reflecting,exhibit |
R8888 | T13337 | T13340 | amod | redundant,activities |
R8889 | T13338 | T13340 | compound | NF-κB,activities |
R8890 | T13339 | T13340 | compound | inhibitory,activities |
R8891 | T13340 | T13336 | dobj | activities,reflecting |
R8892 | T13341 | T13340 | prep | of,activities |
R8893 | T13342 | T13346 | amod | multiple,] |
R8894 | T13343 | T13344 | compound | ABINs,[ |
R8895 | T13344 | T13346 | compound | [,] |
R8896 | T13345 | T13346 | compound | "55,56",] |
R8897 | T13346 | T13341 | pobj | ],of |
R8898 | T13347 | T13324 | punct | .,exhibit |
R8899 | T13348 | T13349 | compound | Functional,ABIN-3 |
R8900 | T13349 | T13351 | nsubjpass | ABIN-3,expressed |
R8901 | T13350 | T13351 | auxpass | is,expressed |
R8902 | T13351 | T13351 | ROOT | expressed,expressed |
R8903 | T13352 | T13351 | prep | in,expressed |
R8904 | T13353 | T13352 | pobj | humans,in |
R8905 | T13354 | T13351 | punct | ",",expressed |
R8906 | T13355 | T13351 | cc | but,expressed |
R8907 | T13356 | T13358 | nsubj | mice,express |
R8908 | T13357 | T13358 | advmod | only,express |
R8909 | T13358 | T13351 | conj | express,expressed |
R8910 | T13359 | T13363 | det | a,form |
R8911 | T13360 | T13363 | amod | truncated,form |
R8912 | T13361 | T13360 | cc | and,truncated |
R8913 | T13362 | T13360 | conj | inactive,truncated |
R8914 | T13363 | T13358 | dobj | form,express |
R8915 | T13364 | T13363 | acl | lacking,form |
R8916 | T13365 | T13368 | det | the,domain |
R8917 | T13366 | T13368 | amod | crucial,domain |
R8918 | T13367 | T13368 | compound | ubiquitin-binding,domain |
R8919 | T13368 | T13364 | dobj | domain,lacking |
R8920 | T13369 | T13371 | nmod | [,] |
R8921 | T13370 | T13371 | nummod | 57,] |
R8922 | T13371 | T13368 | appos | ],domain |
R8923 | T13372 | T13358 | punct | .,express |
R8924 | T13373 | T13380 | prep | As,inhibits |
R8925 | T13374 | T13373 | prep | for,As |
R8926 | T13375 | T13374 | pobj | A20,for |
R8927 | T13376 | T13380 | punct | ",",inhibits |
R8928 | T13377 | T13380 | nsubj | ABIN-1,inhibits |
R8929 | T13378 | T13380 | advmod | also,inhibits |
R8930 | T13379 | T13380 | advmod | strongly,inhibits |
R8931 | T13380 | T13380 | ROOT | inhibits,inhibits |
R8932 | T13381 | T13382 | amod | TNF-induced,apoptosis |
R8933 | T13382 | T13383 | compound | apoptosis,[ |
R8934 | T13383 | T13380 | dobj | [,inhibits |
R8935 | T13384 | T13385 | nummod | 58,] |
R8936 | T13385 | T13390 | nmod | ],mice |
R8937 | T13386 | T13385 | punct | ",",] |
R8938 | T13387 | T13385 | cc | and,] |
R8939 | T13388 | T13385 | conj | ABIN-1,] |
R8940 | T13389 | T13390 | amod | deficient,mice |
R8941 | T13390 | T13391 | nsubj | mice,die |
R8942 | T13391 | T13380 | conj | die,inhibits |
R8943 | T13392 | T13393 | advmod | embryonically,due |
R8944 | T13393 | T13391 | prep | due,die |
R8945 | T13394 | T13398 | nmod | to,apoptosis |
R8946 | T13395 | T13398 | amod | TNF-dependent,apoptosis |
R8947 | T13396 | T13397 | amod | foetal,liver |
R8948 | T13397 | T13398 | compound | liver,apoptosis |
R8949 | T13398 | T13393 | xcomp | apoptosis,due |
R8950 | T13399 | T13401 | nmod | [,] |
R8951 | T13400 | T13401 | nummod | 56,] |
R8952 | T13401 | T13398 | appos | ],apoptosis |
R8953 | T13402 | T13391 | punct | .,die |
R8954 | T13403 | T13410 | advcl | Using,identified |
R8955 | T13404 | T13406 | nmod | oligonucleotide,analysis |
R8956 | T13405 | T13406 | compound | microarray,analysis |
R8957 | T13406 | T13403 | dobj | analysis,Using |
R8958 | T13407 | T13410 | punct | ",",identified |
R8959 | T13408 | T13410 | nsubjpass | ABIN-1,identified |
R8960 | T13409 | T13410 | auxpass | was,identified |
R8961 | T13410 | T13410 | ROOT | identified,identified |
R8962 | T13411 | T13410 | prep | among,identified |
R8963 | T13412 | T13413 | amod | TNF-induced,genes |
R8964 | T13413 | T13411 | pobj | genes,among |
R8965 | T13414 | T13410 | prep | in,identified |
R8966 | T13415 | T13416 | amod | human,synoviocytes |
R8967 | T13416 | T13414 | pobj | synoviocytes,in |
R8968 | T13417 | T13410 | punct | ",",identified |
R8969 | T13418 | T13410 | cc | and,identified |
R8970 | T13419 | T13420 | amod | high,levels |
R8971 | T13420 | T13425 | nsubjpass | levels,detected |
R8972 | T13421 | T13420 | prep | of,levels |
R8973 | T13422 | T13423 | compound | ABIN-1,mRNA |
R8974 | T13423 | T13421 | pobj | mRNA,of |
R8975 | T13424 | T13425 | auxpass | were,detected |
R8976 | T13425 | T13410 | conj | detected,identified |
R8977 | T13426 | T13425 | prep | in,detected |
R8978 | T13427 | T13429 | compound | RA,biopsies |
R8979 | T13428 | T13429 | compound | tissue,biopsies |
R8980 | T13429 | T13426 | pobj | biopsies,in |
R8981 | T13430 | T13425 | punct | ",",detected |
R8982 | T13431 | T13425 | advcl | indicating,detected |
R8983 | T13432 | T13434 | det | a,role |
R8984 | T13433 | T13434 | amod | potential,role |
R8985 | T13434 | T13431 | dobj | role,indicating |
R8986 | T13435 | T13434 | prep | for,role |
R8987 | T13436 | T13435 | pobj | ABIN-1,for |
R8988 | T13437 | T13431 | punct | ",",indicating |
R8989 | T13438 | T13439 | advmod | together,with |
R8990 | T13439 | T13425 | prep | with,detected |
R8991 | T13440 | T13439 | pobj | A20,with |
R8992 | T13441 | T13425 | punct | ",",detected |
R8993 | T13442 | T13425 | prep | in,detected |
R8994 | T13443 | T13446 | det | the,regulation |
R8995 | T13444 | T13446 | amod | negative,regulation |
R8996 | T13445 | T13446 | compound | feedback,regulation |
R8997 | T13446 | T13442 | pobj | regulation,in |
R8998 | T13447 | T13446 | prep | of,regulation |
R8999 | T13448 | T13449 | compound | NF-κB,signalling |
R9000 | T13449 | T13447 | pobj | signalling,of |
R9001 | T13450 | T13449 | cc | and,signalling |
R9002 | T13451 | T13452 | det | the,pathogenesis |
R9003 | T13452 | T13449 | conj | pathogenesis,signalling |
R9004 | T13453 | T13452 | prep | of,pathogenesis |
R9005 | T13454 | T13455 | compound | RA,[ |
R9006 | T13455 | T13453 | pobj | [,of |
R9007 | T13456 | T13457 | nummod | 59,] |
R9008 | T13457 | T13452 | appos | ],pathogenesis |
R9009 | T13458 | T13425 | punct | .,detected |
R9010 | T13459 | T13480 | prep | In,shown |
R9011 | T13460 | T13462 | det | a,study |
R9012 | T13461 | T13462 | amod | recent,study |
R9013 | T13462 | T13459 | pobj | study,In |
R9014 | T13463 | T13480 | punct | ",",shown |
R9015 | T13464 | T13480 | nsubjpass | inhibition,shown |
R9016 | T13465 | T13464 | prep | of,inhibition |
R9017 | T13466 | T13467 | compound | TLR,responses |
R9018 | T13467 | T13465 | pobj | responses,of |
R9019 | T13468 | T13467 | prep | by,responses |
R9020 | T13469 | T13472 | amod | immunoreceptor,motif |
R9021 | T13470 | T13472 | amod | tyrosine-based,motif |
R9022 | T13471 | T13472 | compound | activation,motif |
R9023 | T13472 | T13468 | pobj | motif,by |
R9024 | T13473 | T13474 | punct | (,ITAM |
R9025 | T13474 | T13472 | appos | ITAM,motif |
R9026 | T13475 | T13474 | punct | ),ITAM |
R9027 | T13476 | T13472 | punct | -,motif |
R9028 | T13477 | T13478 | amod | coupled,receptors |
R9029 | T13478 | T13480 | nsubjpass | receptors,shown |
R9030 | T13479 | T13480 | auxpass | was,shown |
R9031 | T13480 | T13480 | ROOT | shown,shown |
R9032 | T13481 | T13482 | aux | to,depend |
R9033 | T13482 | T13480 | xcomp | depend,shown |
R9034 | T13483 | T13482 | prep | on,depend |
R9035 | T13484 | T13485 | det | the,expression |
R9036 | T13485 | T13483 | pobj | expression,on |
R9037 | T13486 | T13485 | prep | of,expression |
R9038 | T13487 | T13490 | det | the,proteins |
R9039 | T13488 | T13490 | amod | NF-κB,proteins |
R9040 | T13489 | T13490 | compound | inhibitory,proteins |
R9042 | T13491 | T13485 | appos | ABIN-3,expression |
R9043 | T13492 | T13491 | cc | and,ABIN-3 |
R9044 | T13493 | T13491 | conj | A20,ABIN-3 |
R9045 | T13494 | T13480 | punct | .,shown |
R9046 | T13495 | T13505 | advmod | Moreover,suppressed |
R9047 | T13496 | T13505 | punct | ",",suppressed |
R9048 | T13497 | T13499 | det | this,effect |
R9049 | T13498 | T13499 | amod | protective,effect |
R9050 | T13499 | T13505 | nsubjpass | effect,suppressed |
R9051 | T13500 | T13499 | prep | of,effect |
R9052 | T13501 | T13502 | det | the,ITAM |
R9053 | T13502 | T13500 | pobj | ITAM,of |
R9054 | T13503 | T13505 | auxpass | was,suppressed |
R9055 | T13504 | T13505 | advmod | strongly,suppressed |
R9056 | T13505 | T13505 | ROOT | suppressed,suppressed |
R9057 | T13506 | T13505 | prep | in,suppressed |
R9058 | T13507 | T13508 | amod | inflammatory,arthritis |
R9059 | T13508 | T13506 | pobj | arthritis,in |
R9060 | T13509 | T13510 | amod | synovial,macrophages |
R9061 | T13510 | T13511 | compound | macrophages,[ |
R9062 | T13511 | T13505 | dobj | [,suppressed |
R9063 | T13512 | T13513 | nummod | 60,] |
R9064 | T13513 | T13511 | appos | ],[ |
R9065 | T13514 | T13505 | punct | .,suppressed |
R9066 | T13515 | T13521 | advmod | Interestingly,associated |
R9067 | T13516 | T13521 | punct | ",",associated |
R9068 | T13517 | T13518 | amod | ABIN-1,polymorphisms |
R9069 | T13518 | T13521 | nsubjpass | polymorphisms,associated |
R9070 | T13519 | T13521 | aux | have,associated |
R9071 | T13520 | T13521 | auxpass | been,associated |
R9072 | T13521 | T13521 | ROOT | associated,associated |
R9073 | T13522 | T13521 | prep | with,associated |
R9074 | T13523 | T13522 | pobj | psoriasis,with |
R9075 | T13524 | T13523 | cc | and,psoriasis |
R9076 | T13525 | T13526 | amod | systemic,lupus |
R9077 | T13526 | T13523 | conj | lupus,psoriasis |
R9078 | T13527 | T13521 | conj | erythematosus,associated |
R9079 | T13528 | T13527 | prep | in,erythematosus |
R9080 | T13529 | T13528 | pobj | humans,in |
R9081 | T13530 | T13532 | compound | [,] |
R9082 | T13531 | T13532 | compound | "61,62",] |
R9083 | T13532 | T13521 | nsubjpass | ],associated |
R9084 | T13533 | T13521 | punct | .,associated |
R9085 | T13534 | T13536 | det | A,degree |
R9086 | T13535 | T13536 | amod | high,degree |
R9087 | T13536 | T13549 | nsubjpass | degree,expected |
R9088 | T13537 | T13536 | prep | of,degree |
R9089 | T13538 | T13537 | pobj | overlap,of |
R9090 | T13539 | T13538 | prep | between,overlap |
R9091 | T13540 | T13542 | amod | systemic,erythematosus |
R9092 | T13541 | T13542 | compound | lupus,erythematosus |
R9093 | T13542 | T13539 | pobj | erythematosus,between |
R9094 | T13543 | T13542 | cc | and,erythematosus |
R9095 | T13544 | T13545 | compound | RA,susceptibility |
R9096 | T13545 | T13546 | compound | susceptibility,loci |
R9097 | T13546 | T13542 | conj | loci,erythematosus |
R9098 | T13547 | T13549 | aux | might,expected |
R9099 | T13548 | T13549 | auxpass | be,expected |
R9100 | T13549 | T13549 | ROOT | expected,expected |
R9101 | T13550 | T13554 | mark | as,show |
R9102 | T13551 | T13553 | det | the,diseases |
R9103 | T13552 | T13553 | nummod | two,diseases |
R9104 | T13553 | T13554 | nsubj | diseases,show |
R9105 | T13554 | T13549 | advcl | show,expected |
R9106 | T13555 | T13557 | det | some,overlap |
R9107 | T13556 | T13557 | amod | clinical,overlap |
R9108 | T13557 | T13554 | dobj | overlap,show |
R9109 | T13558 | T13557 | prep | in,overlap |
R9110 | T13559 | T13560 | amod | joint,involvement |
R9111 | T13560 | T13558 | pobj | involvement,in |
R9112 | T13561 | T13557 | punct | ",",overlap |
R9113 | T13562 | T13563 | compound | autoantibody,production |
R9114 | T13563 | T13557 | conj | production,overlap |
R9115 | T13564 | T13563 | punct | ",",production |
R9116 | T13565 | T13566 | amod | systemic,features |
R9117 | T13566 | T13563 | conj | features,production |
R9118 | T13567 | T13566 | cc | and,features |
R9119 | T13568 | T13566 | conj | response,features |
R9120 | T13569 | T13568 | prep | to,response |
R9121 | T13570 | T13569 | pobj | treatments,to |
R9122 | T13571 | T13572 | amod | such,as |
R9123 | T13572 | T13570 | prep | as,treatments |
R9124 | T13573 | T13574 | compound | B-cell,depletion |
R9125 | T13574 | T13572 | pobj | depletion,as |
R9126 | T13575 | T13574 | punct | (,depletion |
R9127 | T13576 | T13574 | appos | rituximab,depletion |
R9128 | T13577 | T13574 | punct | ),depletion |
R9129 | T13578 | T13549 | punct | .,expected |
R9130 | T13579 | T13582 | nsubj | It,be |
R9131 | T13580 | T13582 | aux | will,be |
R9132 | T13581 | T13582 | advmod | therefore,be |
R9133 | T13582 | T13582 | ROOT | be,be |
R9134 | T13583 | T13582 | acomp | interesting,be |
R9135 | T13584 | T13585 | aux | to,investigate |
R9136 | T13585 | T13582 | xcomp | investigate,be |
R9137 | T13586 | T13601 | mark | whether,associated |
R9138 | T13587 | T13601 | nsubjpass | SNPs,associated |
R9139 | T13588 | T13591 | nsubjpass | that,reported |
R9140 | T13589 | T13591 | aux | have,reported |
R9141 | T13590 | T13591 | auxpass | been,reported |
R9142 | T13591 | T13587 | relcl | reported,SNPs |
R9143 | T13592 | T13594 | aux | to,associated |
R9144 | T13593 | T13594 | auxpass | be,associated |
R9145 | T13594 | T13591 | xcomp | associated,reported |
R9146 | T13595 | T13594 | prep | with,associated |
R9147 | T13596 | T13598 | amod | systemic,erythematosus |
R9148 | T13597 | T13598 | compound | lupus,erythematosus |
R9149 | T13598 | T13595 | pobj | erythematosus,with |
R9150 | T13599 | T13601 | auxpass | are,associated |
R9151 | T13600 | T13601 | advmod | also,associated |
R9152 | T13601 | T13585 | ccomp | associated,investigate |
R9153 | T13602 | T13601 | prep | with,associated |
R9154 | T13603 | T13602 | pobj | RA,with |
R9155 | T13604 | T13582 | punct | .,be |
R9695 | T14673 | T14675 | compound | Cylindromatosis,Cylindromatosis |
R9696 | T14674 | T14675 | compound | protein,Cylindromatosis |
R9697 | T14675 | T14682 | nsubjpass | Cylindromatosis,identified |
R9698 | T14676 | T14677 | punct | (,CYLD |
R9699 | T14677 | T14675 | appos | CYLD,Cylindromatosis |
R9700 | T14678 | T14677 | punct | ),CYLD |
R9701 | T14679 | T14682 | nsubjpass | protein,identified |
R9702 | T14680 | T14682 | auxpass | was,identified |
R9703 | T14681 | T14682 | advmod | originally,identified |
R9704 | T14682 | T14682 | ROOT | identified,identified |
R9705 | T14683 | T14682 | prep | as,identified |
R9706 | T14684 | T14686 | det | a,suppressor |
R9707 | T14685 | T14686 | compound | tumour,suppressor |
R9708 | T14686 | T14683 | pobj | suppressor,as |
R9709 | T14687 | T14686 | acl | involved,suppressor |
R9710 | T14688 | T14687 | prep | in,involved |
R9711 | T14689 | T14690 | amod | familial,cylindromatosis |
R9712 | T14690 | T14691 | compound | cylindromatosis,[ |
R9713 | T14691 | T14688 | pobj | [,in |
R9714 | T14692 | T14693 | nummod | 63,] |
R9715 | T14693 | T14691 | appos | ],[ |
R9716 | T14694 | T14682 | punct | .,identified |
R9717 | T14695 | T14698 | nsubjpass | CYLD,involved |
R9718 | T14696 | T14698 | auxpass | is,involved |
R9719 | T14697 | T14698 | advmod | also,involved |
R9720 | T14698 | T14721 | ccomp | involved,reviewed |
R9721 | T14699 | T14721 | punct | ",",reviewed |
R9722 | T14700 | T14721 | advmod | however,reviewed |
R9723 | T14701 | T14721 | punct | ",",reviewed |
R9724 | T14702 | T14721 | prep | in,reviewed |
R9725 | T14703 | T14705 | amod | diverse,processes |
R9726 | T14704 | T14705 | amod | physiological,processes |
R9727 | T14705 | T14702 | pobj | processes,in |
R9728 | T14706 | T14705 | acl | ranging,processes |
R9729 | T14707 | T14706 | prep | from,ranging |
R9730 | T14708 | T14707 | pobj | immunity,from |
R9731 | T14709 | T14708 | cc | and,immunity |
R9732 | T14710 | T14708 | conj | inflammation,immunity |
R9733 | T14711 | T14721 | prep | to,reviewed |
R9734 | T14712 | T14713 | compound | cell,cycle |
R9735 | T14713 | T14714 | compound | cycle,progression |
R9736 | T14714 | T14711 | pobj | progression,to |
R9737 | T14715 | T14714 | punct | ",",progression |
R9738 | T14716 | T14714 | conj | spermatogenesis,progression |
R9739 | T14717 | T14716 | punct | ",",spermatogenesis |
R9740 | T14718 | T14716 | cc | and,spermatogenesis |
R9741 | T14719 | T14716 | conj | osteoclastogenesis,spermatogenesis |
R9742 | T14720 | T14721 | punct | (,reviewed |
R9743 | T14721 | T14721 | ROOT | reviewed,reviewed |
R9744 | T14722 | T14721 | prep | in,reviewed |
R9745 | T14723 | T14722 | pobj | [,in |
R9746 | T14724 | T14725 | nummod | 64,] |
R9747 | T14725 | T14723 | appos | ],[ |
R9748 | T14726 | T14723 | punct | ),[ |
R9749 | T14727 | T14721 | punct | .,reviewed |
R9750 | T14728 | T14729 | nsubj | CYLD,is |
R9751 | T14729 | T14729 | ROOT | is,is |
R9752 | T14730 | T14732 | det | a,enzyme |
R9753 | T14731 | T14732 | amod | deubiquitinating,enzyme |
R9754 | T14732 | T14729 | attr | enzyme,is |
R9755 | T14733 | T14735 | nsubj | that,regulates |
R9756 | T14734 | T14735 | advmod | negatively,regulates |
R9757 | T14735 | T14732 | relcl | regulates,enzyme |
R9758 | T14736 | T14737 | amod | NF-κB,signalling |
R9759 | T14737 | T14735 | xcomp | signalling,regulates |
R9760 | T14738 | T14737 | acl | initiated,signalling |
R9761 | T14739 | T14738 | agent | by,initiated |
R9762 | T14740 | T14739 | pobj | TNFR,by |
R9763 | T14741 | T14740 | punct | ",",TNFR |
R9764 | T14742 | T14740 | conj | RANK,TNFR |
R9765 | T14743 | T14742 | cc | and,RANK |
R9766 | T14744 | T14742 | conj | T-cell,RANK |
R9767 | T14745 | T14746 | compound | receptor,stimulation |
R9768 | T14746 | T14740 | appos | stimulation,TNFR |
R9769 | T14747 | T14748 | punct | (,reviewed |
R9770 | T14748 | T14737 | acl | reviewed,signalling |
R9771 | T14749 | T14748 | prep | in,reviewed |
R9772 | T14750 | T14749 | pobj | [,in |
R9773 | T14751 | T14752 | nummod | 64,] |
R9774 | T14752 | T14750 | appos | ],[ |
R9775 | T14753 | T14750 | punct | ),[ |
R9776 | T14754 | T14755 | punct | (,Figure |
R9777 | T14755 | T14748 | appos | Figure,reviewed |
R9778 | T14756 | T14755 | nummod | 1,Figure |
R9779 | T14757 | T14755 | punct | ),Figure |
R9780 | T14758 | T14755 | punct | ",",Figure |
R9781 | T14759 | T14755 | prep | by,Figure |
R9782 | T14760 | T14764 | amod | deubiquitina-ting,proteins |
R9783 | T14761 | T14764 | amod | several,proteins |
R9784 | T14762 | T14763 | npadvmod | NF-κB,signalling |
R9785 | T14763 | T14764 | amod | signalling,proteins |
R9786 | T14764 | T14759 | pobj | proteins,by |
R9787 | T14765 | T14764 | prep | including,proteins |
R9788 | T14766 | T14765 | pobj | NEMO,including |
R9789 | T14767 | T14766 | punct | ",",NEMO |
R9790 | T14768 | T14766 | conj | TRAF2,NEMO |
R9791 | T14769 | T14768 | punct | ",",TRAF2 |
R9792 | T14770 | T14768 | conj | TRAF6,TRAF2 |
R9793 | T14771 | T14770 | punct | ",",TRAF6 |
R9794 | T14772 | T14770 | conj | TRAF7,TRAF6 |
R9795 | T14773 | T14772 | punct | ",",TRAF7 |
R9796 | T14774 | T14772 | conj | RIP1,TRAF7 |
R9797 | T14775 | T14774 | cc | and,RIP1 |
R9798 | T14776 | T14774 | conj | TAK1,RIP1 |
R9799 | T14777 | T14755 | punct | .,Figure |
R9800 | T14778 | T14783 | nsubjpass | Many,targeted |
R9801 | T14779 | T14778 | prep | of,Many |
R9802 | T14780 | T14779 | pobj | these,of |
R9803 | T14781 | T14783 | auxpass | are,targeted |
R9804 | T14782 | T14783 | advmod | also,targeted |
R9805 | T14783 | T14783 | ROOT | targeted,targeted |
R9806 | T14784 | T14783 | agent | by,targeted |
R9807 | T14785 | T14784 | pobj | A20,by |
R9808 | T14786 | T14783 | cc | and,targeted |
R9809 | T14787 | T14788 | nsubj | it,is |
R9810 | T14788 | T14783 | conj | is,targeted |
R9811 | T14789 | T14788 | advmod | still,is |
R9812 | T14790 | T14788 | neg | not,is |
R9813 | T14791 | T14788 | acomp | clear,is |
R9814 | T14792 | T14795 | advmod | why,needs |
R9815 | T14793 | T14794 | det | the,cell |
R9816 | T14794 | T14795 | nsubj | cell,needs |
R9817 | T14795 | T14788 | ccomp | needs,is |
R9818 | T14796 | T14802 | nsubj | A20,control |
R9819 | T14797 | T14799 | advmod | as,as |
R9820 | T14798 | T14799 | advmod | well,as |
R9821 | T14799 | T14796 | cc | as,A20 |
R9822 | T14800 | T14796 | conj | CYLD,A20 |
R9823 | T14801 | T14802 | aux | to,control |
R9824 | T14802 | T14795 | ccomp | control,needs |
R9825 | T14803 | T14804 | amod | NF-κB,activation |
R9826 | T14804 | T14802 | dobj | activation,control |
R9827 | T14805 | T14788 | punct | .,is |
R9828 | T14806 | T14810 | mark | As,expressed |
R9829 | T14807 | T14810 | nsubjpass | A20,expressed |
R9830 | T14808 | T14810 | auxpass | is,expressed |
R9831 | T14809 | T14810 | advmod | only,expressed |
R9832 | T14810 | T14821 | advcl | expressed,suggested |
R9833 | T14811 | T14810 | prep | in,expressed |
R9834 | T14812 | T14814 | amod | many,types |
R9835 | T14813 | T14814 | compound | cell,types |
R9836 | T14814 | T14811 | pobj | types,in |
R9837 | T14815 | T14810 | prep | upon,expressed |
R9838 | T14816 | T14815 | pobj | stimulation,upon |
R9839 | T14817 | T14821 | punct | ",",suggested |
R9840 | T14818 | T14821 | nsubjpass | it,suggested |
R9841 | T14819 | T14821 | aux | has,suggested |
R9842 | T14820 | T14821 | auxpass | been,suggested |
R9843 | T14821 | T14821 | ROOT | suggested,suggested |
R9844 | T14822 | T14826 | mark | that,regulates |
R9845 | T14823 | T14824 | det | this,protein |
R9846 | T14824 | T14826 | nsubj | protein,regulates |
R9847 | T14825 | T14826 | advmod | mainly,regulates |
R9848 | T14826 | T14821 | ccomp | regulates,suggested |
R9849 | T14827 | T14828 | amod | later,phases |
R9850 | T14828 | T14826 | dobj | phases,regulates |
R9851 | T14829 | T14828 | prep | of,phases |
R9852 | T14830 | T14831 | amod | NF-κB,signalling |
R9853 | T14831 | T14829 | pobj | signalling,of |
R9854 | T14832 | T14826 | punct | ",",regulates |
R9855 | T14833 | T14836 | mark | whereas,regulate |
R9856 | T14834 | T14836 | nsubj | CYLD,regulate |
R9857 | T14835 | T14836 | aux | would,regulate |
R9858 | T14836 | T14826 | advcl | regulate,regulates |
R9859 | T14837 | T14836 | dobj | constitutive,regulate |
R9860 | T14838 | T14837 | cc | and,constitutive |
R9861 | T14839 | T14840 | amod | early,signalling |
R9862 | T14840 | T14837 | conj | signalling,constitutive |
R9863 | T14841 | T14821 | punct | .,suggested |
R9864 | T14842 | T14850 | prep | In,be |
R9865 | T14843 | T14842 | pobj | addition,In |
R9866 | T14844 | T14850 | punct | ",",be |
R9867 | T14845 | T14847 | poss | their,activity |
R9868 | T14846 | T14847 | amod | relative,activity |
R9869 | T14847 | T14850 | nsubj | activity,be |
R9870 | T14848 | T14850 | aux | might,be |
R9871 | T14849 | T14850 | advmod | also,be |
R9872 | T14850 | T14850 | ROOT | be,be |
R9873 | T14851 | T14852 | npadvmod | cell-type,dependent |
R9874 | T14852 | T14855 | amod | dependent,] |
R9875 | T14853 | T14855 | nmod | [,] |
R9876 | T14854 | T14855 | nummod | 64,] |
R9877 | T14855 | T14850 | attr | ],be |
R9878 | T14856 | T14850 | punct | .,be |
R9879 | T14857 | T14862 | advmod | Interestingly,shown |
R9880 | T14858 | T14862 | punct | ",",shown |
R9881 | T14859 | T14862 | nsubjpass | CYLD,shown |
R9882 | T14860 | T14862 | aux | has,shown |
R9883 | T14861 | T14862 | auxpass | been,shown |
R9884 | T14862 | T14862 | ROOT | shown,shown |
R9885 | T14863 | T14865 | aux | to,regulate |
R9886 | T14864 | T14865 | advmod | negatively,regulate |
R9887 | T14865 | T14862 | xcomp | regulate,shown |
R9888 | T14866 | T14867 | compound | RANK,signalling |
R9889 | T14867 | T14865 | dobj | signalling,regulate |
R9890 | T14868 | T14867 | cc | and,signalling |
R9891 | T14869 | T14867 | conj | osteoclastogenesis,signalling |
R9892 | T14870 | T14867 | prep | in,signalling |
R9893 | T14871 | T14870 | pobj | mice,in |
R9894 | T14872 | T14874 | nmod | [,] |
R9895 | T14873 | T14874 | nummod | 65,] |
R9896 | T14874 | T14867 | appos | ],signalling |
R9897 | T14875 | T14862 | punct | .,shown |
R9898 | T14876 | T14883 | nsubj | Mice,have |
R9899 | T14877 | T14876 | prep | with,Mice |
R9900 | T14878 | T14880 | det | a,deficiency |
R9901 | T14879 | T14880 | amod | genetic,deficiency |
R9902 | T14880 | T14877 | pobj | deficiency,with |
R9903 | T14881 | T14880 | prep | of,deficiency |
R9904 | T14882 | T14881 | pobj | CYLD,of |
R9905 | T14883 | T14883 | ROOT | have,have |
R9906 | T14884 | T14886 | amod | aberrant,differentiation |
R9907 | T14885 | T14886 | compound | osteoclast,differentiation |
R9908 | T14886 | T14883 | dobj | differentiation,have |
R9909 | T14887 | T14883 | cc | and,have |
R9910 | T14888 | T14883 | conj | develop,have |
R9911 | T14889 | T14890 | amod | severe,osteoporosis |
R9912 | T14890 | T14888 | dobj | osteoporosis,develop |
R9913 | T14891 | T14883 | punct | .,have |
R9914 | T14892 | T14897 | dep | Osteoclast,are |
R9915 | T14893 | T14897 | nsubj | precursors,are |
R9916 | T14894 | T14893 | prep | of,precursors |
R9917 | T14895 | T14896 | det | these,mice |
R9918 | T14896 | T14894 | pobj | mice,of |
R9919 | T14897 | T14897 | ROOT | are,are |
R9920 | T14898 | T14897 | acomp | hyper-responsive,are |
R9921 | T14899 | T14898 | prep | to,hyper-responsive |
R9922 | T14900 | T14901 | amod | RANKL-induced,differentiation |
R9923 | T14901 | T14899 | pobj | differentiation,to |
R9924 | T14902 | T14897 | cc | and,are |
R9925 | T14903 | T14897 | conj | produce,are |
R9926 | T14904 | T14907 | amod | more,osteoclasts |
R9927 | T14905 | T14904 | cc | and,more |
R9928 | T14906 | T14904 | conj | larger,more |
R9929 | T14907 | T14903 | dobj | osteoclasts,produce |
R9930 | T14908 | T14897 | punct | .,are |
R9931 | T14909 | T14910 | compound | CYLD,expression |
R9932 | T14910 | T14913 | nsubjpass | expression,upregulated |
R9933 | T14911 | T14913 | auxpass | is,upregulated |
R9934 | T14912 | T14913 | advmod | markedly,upregulated |
R9935 | T14913 | T14913 | ROOT | upregulated,upregulated |
R9936 | T14914 | T14913 | prep | under,upregulated |
R9937 | T14915 | T14914 | pobj | conditions,under |
R9938 | T14916 | T14915 | prep | of,conditions |
R9939 | T14917 | T14918 | compound | RANKL-induced,osteoclastogenesis |
R9940 | T14918 | T14916 | pobj | osteoclastogenesis,of |
R9941 | T14919 | T14913 | cc | and,upregulated |
R9942 | T14920 | T14921 | auxpass | is,recruited |
R9943 | T14921 | T14913 | conj | recruited,upregulated |
R9944 | T14922 | T14921 | prep | to,recruited |
R9945 | T14923 | T14924 | amod | ubiquitinated,TRAF6 |
R9946 | T14924 | T14922 | pobj | TRAF6,to |
R9947 | T14925 | T14921 | prep | via,recruited |
R9948 | T14926 | T14929 | det | the,protein |
R9949 | T14927 | T14929 | amod | ubiquitin-binding,protein |
R9955 | T14933 | T14930 | acl | known,p62 |
R9956 | T14934 | T14933 | prep | as,known |
R9957 | T14935 | T14934 | pobj | sequestosome,as |
R9958 | T14936 | T14935 | nummod | 1,sequestosome |
R9959 | T14937 | T14930 | punct | ),p62 |
R9960 | T14938 | T14940 | nmod | [,] |
R9961 | T14939 | T14940 | nummod | 65,] |
R9962 | T14940 | T14940 | ROOT | ],] |
R9963 | T14941 | T14940 | punct | ",",] |
R9964 | T14942 | T14940 | acl | followed,] |
R9965 | T14943 | T14942 | agent | by,followed |
R9966 | T14944 | T14946 | det | the,deubiquitination |
R9967 | T14945 | T14946 | amod | CYLD-mediated,deubiquitination |
R9968 | T14946 | T14943 | pobj | deubiquitination,by |
R9969 | T14947 | T14946 | prep | of,deubiquitination |
R9970 | T14948 | T14947 | pobj | TRAF6,of |
R9971 | T14949 | T14913 | punct | .,upregulated |
R9972 | T14950 | T14955 | prep | In,is |
R9973 | T14951 | T14952 | det | this,context |
R9974 | T14952 | T14950 | pobj | context,In |
R9975 | T14953 | T14955 | punct | ",",is |
R9976 | T14954 | T14955 | nsubj | it,is |
R9977 | T14955 | T14955 | ROOT | is,is |
R9978 | T14956 | T14955 | acomp | worth,is |
R9979 | T14957 | T14956 | xcomp | mentioning,worth |
R9980 | T14958 | T14968 | mark | that,display |
R9981 | T14959 | T14960 | amod | transgenic,mice |
R9982 | T14960 | T14968 | nsubj | mice,display |
R9983 | T14961 | T14960 | acl | expressing,mice |
R9984 | T14962 | T14964 | det | a,form |
R9985 | T14963 | T14964 | amod | mutated,form |
R9986 | T14964 | T14961 | dobj | form,expressing |
R9987 | T14965 | T14964 | prep | of,form |
R9988 | T14966 | T14965 | pobj | p62,of |
R9989 | T14967 | T14968 | advmod | also,display |
R9990 | T14968 | T14955 | ccomp | display,is |
R9991 | T14969 | T14970 | amod | abnormal,osteoclastogenesis |
R9992 | T14970 | T14968 | dobj | osteoclastogenesis,display |
R9993 | T14971 | T14968 | cc | and,display |
R9994 | T14972 | T14968 | conj | develop,display |
R9995 | T14973 | T14975 | amod | progressive,loss |
R9996 | T14974 | T14975 | compound | bone,loss |
R9997 | T14975 | T14972 | dobj | loss,develop |
R9998 | T14976 | T14978 | nmod | [,] |
R9999 | T14977 | T14978 | nummod | 66,] |
R10000 | T14978 | T14975 | appos | ],loss |
R10001 | T14979 | T14955 | punct | .,is |
R10002 | T14980 | T14981 | det | These,findings |
R10003 | T14981 | T14982 | nsubj | findings,suggest |
R10004 | T14982 | T14982 | ROOT | suggest,suggest |
R10005 | T14983 | T15001 | mark | that,indicate |
R10006 | T14984 | T14985 | amod | CYLD-mediated,inhibi-tion |
R10007 | T14985 | T15001 | nsubj | inhibi-tion,indicate |
R10008 | T14986 | T14985 | prep | of,inhibi-tion |
R10009 | T14987 | T14988 | amod | RANK-induced,NF-κB |
R10010 | T14988 | T14989 | nsubj | NF-κB,signalling |
R10011 | T14989 | T14986 | pcomp | signalling,of |
R10012 | T14990 | T14989 | dobj | plays,signalling |
R10013 | T14991 | T14993 | det | a,role |
R10014 | T14992 | T14993 | amod | key,role |
R10015 | T14993 | T14989 | oprd | role,signalling |
R10016 | T14994 | T14993 | prep | in,role |
R10017 | T14995 | T14997 | det | the,regulation |
R10018 | T14996 | T14997 | amod | negative,regulation |
R10019 | T14997 | T14994 | pobj | regulation,in |
R10020 | T14998 | T14997 | prep | of,regulation |
R10021 | T14999 | T14998 | pobj | osteoclastogenesis,of |
R10022 | T15000 | T14989 | cc | and,signalling |
R10023 | T15001 | T14982 | ccomp | indicate,suggest |
R10029 | T15007 | T15003 | pobj | factor,as |
R10030 | T15008 | T15007 | acl | involved,factor |
R10031 | T15009 | T15008 | prep | in,involved |
R10032 | T15010 | T15011 | det | the,pathology |
R10033 | T15011 | T15009 | pobj | pathology,in |
R10034 | T15012 | T15011 | prep | of,pathology |
R10035 | T15013 | T15014 | compound | bone,disorders |
R10036 | T15014 | T15012 | pobj | disorders,of |
R10037 | T15015 | T15016 | amod | such,as |
R10038 | T15016 | T15014 | prep | as,disorders |
R10039 | T15017 | T15016 | pobj | RA,as |
R10040 | T15018 | T14982 | punct | .,suggest |
R10438 | T15830 | T15847 | nsubj | Single-immunoglobulin,is |
R10439 | T15831 | T15833 | amod | IL-1,protein |
R10440 | T15832 | T15833 | amod | receptor-related,protein |
R10441 | T15833 | T15847 | nsubj | protein,is |
R10442 | T15834 | T15840 | nmod | Single-immunoglobulin,protein |
R10443 | T15835 | T15836 | compound | IL-1,receptor-related |
R10444 | T15836 | T15840 | compound | receptor-related,protein |
R10445 | T15837 | T15838 | punct | (,SIGIRR |
R10446 | T15838 | T15836 | appos | SIGIRR,receptor-related |
R10447 | T15839 | T15838 | punct | ),SIGIRR |
R10448 | T15840 | T15833 | appos | protein,protein |
R10449 | T15841 | T15840 | punct | ",",protein |
R10450 | T15842 | T15843 | advmod | also,known |
R10451 | T15843 | T15833 | acl | known,protein |
R10452 | T15844 | T15843 | prep | as,known |
R10453 | T15845 | T15844 | pobj | TIR-8,as |
R10454 | T15846 | T15833 | punct | ",",protein |
R10455 | T15847 | T15847 | ROOT | is,is |
R10456 | T15848 | T15849 | det | a,member |
R10457 | T15849 | T15847 | attr | member,is |
R10458 | T15850 | T15849 | prep | of,member |
R10459 | T15851 | T15855 | det | the,family |
R10460 | T15852 | T15855 | compound | TLR/IL,family |
R10461 | T15853 | T15854 | nummod | -1,R |
R10462 | T15854 | T15855 | compound | R,family |
R10463 | T15855 | T15850 | pobj | family,of |
R10464 | T15856 | T15860 | nsubjpass | that,characterised |
R10465 | T15857 | T15860 | aux | has,characterised |
R10466 | T15858 | T15860 | auxpass | been,characterised |
R10467 | T15859 | T15860 | advmod | extensively,characterised |
R10468 | T15860 | T15855 | relcl | characterised,family |
R10469 | T15861 | T15860 | prep | as,characterised |
R10470 | T15862 | T15863 | det | an,inhibitor |
R10471 | T15863 | T15861 | pobj | inhibitor,as |
R10472 | T15864 | T15863 | prep | of,inhibitor |
R10473 | T15865 | T15864 | pobj | IL-1R,of |
R10474 | T15866 | T15865 | cc | and,IL-1R |
R10475 | T15867 | T15868 | compound | TLR,signalling |
R10476 | T15868 | T15865 | conj | signalling,IL-1R |
R10477 | T15869 | T15847 | punct | ",",is |
R10478 | T15870 | T15871 | advmod | probably,through |
R10479 | T15871 | T15847 | prep | through,is |
R10480 | T15872 | T15873 | amod | direct,interaction |
R10481 | T15873 | T15871 | pobj | interaction,through |
R10482 | T15874 | T15873 | prep | with,interaction |
R10483 | T15875 | T15876 | det | these,receptors |
R10484 | T15876 | T15874 | pobj | receptors,with |
R10485 | T15877 | T15873 | punct | ",",interaction |
R10486 | T15878 | T15873 | conj | MyD88,interaction |
R10487 | T15879 | T15878 | punct | ",",MyD88 |
R10488 | T15880 | T15878 | conj | IRAK1,MyD88 |
R10489 | T15881 | T15880 | cc | or,IRAK1 |
R10490 | T15882 | T15883 | compound | TRAF6,[ |
R10491 | T15883 | T15880 | conj | [,IRAK1 |
R10492 | T15884 | T15885 | nummod | 67,] |
R10493 | T15885 | T15880 | conj | ],IRAK1 |
R10494 | T15886 | T15887 | punct | (,Figure |
R10495 | T15887 | T15885 | appos | Figure,] |
R10496 | T15888 | T15887 | nummod | 1,Figure |
R10497 | T15889 | T15887 | punct | ),Figure |
R10498 | T15890 | T15847 | punct | .,is |
R10499 | T15891 | T15904 | prep | Given,observed |
R10500 | T15892 | T15894 | det | the,role |
R10501 | T15893 | T15894 | amod | important,role |
R10502 | T15894 | T15891 | pobj | role,Given |
R10503 | T15895 | T15894 | prep | of,role |
R10504 | T15896 | T15895 | pobj | IL-1R,of |
R10505 | T15897 | T15896 | cc | and,IL-1R |
R10506 | T15898 | T15896 | conj | TLR,IL-1R |
R10507 | T15899 | T15894 | acl | signalling,role |
R10508 | T15900 | T15899 | prep | in,signalling |
R10509 | T15901 | T15903 | det | the,inflammation |
R10510 | T15902 | T15903 | amod | chronic,inflammation |
R10511 | T15903 | T15900 | pobj | inflammation,in |
R10512 | T15904 | T15904 | ROOT | observed,observed |
R10513 | T15905 | T15904 | prep | in,observed |
R10514 | T15906 | T15907 | compound | RA,[ |
R10515 | T15907 | T15905 | pobj | [,in |
R10516 | T15908 | T15909 | nummod | 68,] |
R10517 | T15909 | T15918 | nsubj | ],is |
R10518 | T15910 | T15909 | punct | ",",] |
R10519 | T15911 | T15913 | det | a,role |
R10520 | T15912 | T15913 | amod | regulatory,role |
R10521 | T15913 | T15909 | appos | role,] |
R10522 | T15914 | T15913 | prep | for,role |
R10523 | T15915 | T15914 | pobj | SIGIRR,for |
R10524 | T15916 | T15913 | prep | in,role |
R10525 | T15917 | T15916 | pobj | RA,in |
R10526 | T15918 | T15904 | ccomp | is,observed |
R10527 | T15919 | T15918 | neg | not,is |
R10528 | T15920 | T15918 | acomp | unlikely,is |
R10529 | T15921 | T15904 | punct | .,observed |
R10530 | T15922 | T15923 | nsubj | SIGIRR,has |
R10531 | T15923 | T15923 | ROOT | has,has |
R10532 | T15924 | T15928 | det | a,pattern |
R10533 | T15925 | T15926 | advmod | very,restricted |
R10534 | T15926 | T15928 | amod | restricted,pattern |
R10535 | T15927 | T15928 | compound | expression,pattern |
R10536 | T15928 | T15923 | dobj | pattern,has |
R10537 | T15929 | T15928 | punct | ",",pattern |
R10538 | T15930 | T15931 | auxpass | being,expressed |
R10539 | T15931 | T15928 | acl | expressed,pattern |
R10540 | T15932 | T15931 | prep | in,expressed |
R10541 | T15933 | T15934 | amod | epithelial,cells |
R10542 | T15934 | T15932 | pobj | cells,in |
R10543 | T15935 | T15934 | punct | ",",cells |
R10544 | T15936 | T15934 | conj | monocytes,cells |
R10545 | T15937 | T15936 | cc | and,monocytes |
R10546 | T15938 | T15940 | amod | immature,cells |
R10547 | T15939 | T15940 | amod | dendritic,cells |
R10548 | T15940 | T15936 | conj | cells,monocytes |
R10549 | T15941 | T15931 | punct | ",",expressed |
R10550 | T15942 | T15931 | cc | but,expressed |
R10551 | T15943 | T15944 | neg | not,in |
R10552 | T15944 | T15923 | prep | in,has |
R10553 | T15945 | T15946 | amod | mature,macro-phages |
R10554 | T15946 | T15944 | pobj | macro-phages,in |
R10555 | T15947 | T15949 | compound | [,] |
R10556 | T15948 | T15949 | compound | "69,70",] |
R10557 | T15949 | T15944 | conj | ],in |
R10558 | T15950 | T15923 | punct | .,has |
R10559 | T15951 | T15956 | advmod | Recently,shown |
R10560 | T15952 | T15956 | punct | ",",shown |
R10561 | T15953 | T15954 | compound | SIGIRR,overexpression |
R10562 | T15954 | T15956 | nsubjpass | overexpression,shown |
R10563 | T15955 | T15956 | auxpass | was,shown |
R10564 | T15956 | T15956 | ROOT | shown,shown |
R10565 | T15957 | T15958 | aux | to,inhibit |
R10566 | T15958 | T15956 | xcomp | inhibit,shown |
R10567 | T15959 | T15961 | det | the,release |
R10568 | T15960 | T15961 | amod | spontaneous,release |
R10569 | T15961 | T15958 | dobj | release,inhibit |
R10570 | T15962 | T15961 | prep | of,release |
R10571 | T15963 | T15964 | amod | inflammatory,cytokines |
R10572 | T15964 | T15962 | pobj | cytokines,of |
R10573 | T15965 | T15961 | prep | by,release |
R10574 | T15966 | T15969 | amod | human,cells |
R10575 | T15967 | T15969 | nmod | RA,cells |
R10576 | T15968 | T15969 | amod | synovial,cells |
R10577 | T15969 | T15965 | pobj | cells,by |
R10578 | T15970 | T15956 | punct | .,shown |
R10579 | T15971 | T15973 | det | This,function |
R10580 | T15972 | T15973 | amod | inhibitory,function |
R10581 | T15973 | T15978 | nsubjpass | function,confirmed |
R10582 | T15974 | T15973 | prep | of,function |
R10583 | T15975 | T15974 | pobj | SIGIRR,of |
R10584 | T15976 | T15978 | auxpass | was,confirmed |
R10585 | T15977 | T15978 | advmod | further,confirmed |
R10586 | T15978 | T15978 | ROOT | confirmed,confirmed |
R10587 | T15979 | T15978 | prep | in,confirmed |
R10588 | T15980 | T15979 | pobj | vivo,in |
R10589 | T15981 | T15978 | punct | ",",confirmed |
R10590 | T15982 | T15985 | mark | since,developed |
R10591 | T15983 | T15984 | amod | SIGIRR-deficient,mice |
R10592 | T15984 | T15985 | nsubj | mice,developed |
R10593 | T15985 | T15978 | advcl | developed,confirmed |
R10594 | T15986 | T15989 | det | a,disease |
R10595 | T15987 | T15988 | advmod | more,severe |
R10596 | T15988 | T15989 | amod | severe,disease |
R10597 | T15989 | T15985 | dobj | disease,developed |
R10598 | T15990 | T15989 | prep | in,disease |
R10599 | T15991 | T15992 | amod | zymosan-induced,arthritis |
R10600 | T15992 | T15990 | pobj | arthritis,in |
R10601 | T15993 | T15989 | punct | ",",disease |
R10602 | T15994 | T15996 | advmod | as,as |
R10603 | T15995 | T15996 | advmod | well,as |
R10604 | T15996 | T15989 | cc | as,disease |
R10605 | T15997 | T16000 | amod | collagen-induced,models |
R10606 | T15998 | T15999 | compound | arthritis,mouse |
R10607 | T15999 | T16000 | compound | mouse,models |
R10608 | T16000 | T15989 | conj | models,disease |
R10609 | T16001 | T16001 | ROOT | [,[ |
R10610 | T16002 | T16003 | nummod | 70,] |
R10611 | T16003 | T16003 | ROOT | ],] |
R10612 | T16004 | T15978 | punct | .,confirmed |
R10613 | T16005 | T16007 | nsubj | It,be |
R10614 | T16006 | T16007 | aux | will,be |
R10615 | T16007 | T16007 | ROOT | be,be |
R10616 | T16008 | T16007 | acomp | interesting,be |
R10617 | T16009 | T16010 | aux | to,compare |
R10618 | T16010 | T16007 | xcomp | compare,be |
R10619 | T16011 | T16012 | det | the,expression |
R10620 | T16012 | T16010 | dobj | expression,compare |
R10621 | T16013 | T16012 | prep | of,expression |
R10622 | T16014 | T16013 | pobj | SIGIRR,of |
R10623 | T16015 | T16010 | prep | in,compare |
R10624 | T16016 | T16017 | compound | RA,patients |
R10625 | T16017 | T16015 | pobj | patients,in |
R10626 | T16018 | T16010 | prep | with,compare |
R10627 | T16019 | T16020 | poss | its,expression |
R10628 | T16020 | T16018 | pobj | expression,with |
R10629 | T16021 | T16020 | prep | in,expression |
R10630 | T16022 | T16023 | compound | control,patients |
R10631 | T16023 | T16021 | pobj | patients,in |
R10632 | T16024 | T16020 | punct | ",",expression |
R10633 | T16025 | T16010 | cc | or,compare |
R10634 | T16026 | T16027 | aux | to,investigate |
R10635 | T16027 | T16010 | conj | investigate,compare |
R10636 | T16028 | T16034 | mark | whether,compromised |
R10637 | T16029 | T16030 | det | the,function |
R10638 | T16030 | T16034 | nsubjpass | function,compromised |
R10639 | T16031 | T16030 | prep | of,function |
R10640 | T16032 | T16031 | pobj | SIGIRR,of |
R10641 | T16033 | T16034 | auxpass | is,compromised |
R10642 | T16034 | T16027 | ccomp | compromised,investigate |
R10643 | T16035 | T16034 | prep | in,compromised |
R10644 | T16036 | T16037 | compound | RA,patients |
R10645 | T16037 | T16035 | pobj | patients,in |
R10646 | T16038 | T16007 | punct | .,be |
R10647 | T16039 | T16049 | prep | Because,be |
R10648 | T16040 | T16039 | pcomp | of,Because |
R10649 | T16041 | T16044 | poss | its,pattern |
R11024 | T16746 | T16748 | nmod | TNF,factor |
R11025 | T16747 | T16748 | amod | receptor-associated,factor |
R11026 | T16748 | T16751 | nsubj | factor,is |
R11027 | T16749 | T16748 | nummod | 1,factor |
R11028 | T16750 | T16748 | nummod | TRAF1,factor |
R11029 | T16751 | T16751 | ROOT | is,is |
R11030 | T16752 | T16754 | det | a,member |
R11031 | T16753 | T16754 | amod | unique,member |
R11032 | T16754 | T16751 | attr | member,is |
R11033 | T16755 | T16754 | prep | of,member |
R11034 | T16756 | T16759 | det | the,family |
R11035 | T16757 | T16759 | compound | TRAF,family |
R11036 | T16758 | T16759 | compound | protein,family |
R11037 | T16759 | T16755 | pobj | family,of |
R11038 | T16760 | T16762 | mark | because,lacks |
R11039 | T16761 | T16762 | nsubj | it,lacks |
R11040 | T16762 | T16751 | advcl | lacks,is |
R11041 | T16763 | T16766 | det | a,domain |
R11042 | T16764 | T16766 | compound | RING,domain |
R11043 | T16765 | T16766 | compound | finger,domain |
R11044 | T16766 | T16762 | dobj | domain,lacks |
R11045 | T16767 | T16762 | cc | and,lacks |
R11046 | T16768 | T16769 | advmod | therefore,lacks |
R11047 | T16769 | T16762 | conj | lacks,lacks |
R11048 | T16770 | T16772 | amod | ubiquitin,activity |
R11049 | T16771 | T16772 | compound | ligase,activity |
R11050 | T16772 | T16769 | dobj | activity,lacks |
R11051 | T16773 | T16751 | punct | .,is |
R11052 | T16774 | T16774 | ROOT | Accumulating,Accumulating |
R11053 | T16775 | T16776 | nsubj | data,support |
R11054 | T16776 | T16774 | dobj | support,Accumulating |
R11055 | T16777 | T16778 | det | a,role |
R11056 | T16778 | T16776 | dobj | role,support |
R11057 | T16779 | T16778 | prep | for,role |
R11058 | T16780 | T16779 | pobj | TRAF1,for |
R11059 | T16781 | T16776 | prep | as,support |
R11060 | T16782 | T16784 | det | both,negative |
R11061 | T16783 | T16784 | det | a,negative |
R11062 | T16784 | T16781 | pobj | negative,as |
R11063 | T16785 | T16784 | cc | and,negative |
R11064 | T16786 | T16788 | det | a,modulator |
R11065 | T16787 | T16788 | amod | positive,modulator |
R11066 | T16788 | T16784 | conj | modulator,negative |
R11092 | T16814 | T16813 | cc | and,TNF |
R11093 | T16815 | T16813 | conj | overexpression,TNF |
R11094 | T16816 | T16815 | prep | of,overexpression |
R11095 | T16817 | T16818 | nummod | TRAF1,inhibits |
R11096 | T16818 | T16816 | pobj | inhibits,of |
R11097 | T16819 | T16821 | nmod | TNF-induced,activation |
R11098 | T16820 | T16821 | compound | NF-κB,activation |
R11099 | T16821 | T16815 | conj | activation,overexpression |
R11100 | T16822 | T16810 | punct | .,is |
R11101 | T16823 | T16825 | amod | TRAF1-deficient,cells |
R11102 | T16824 | T16825 | compound | T,cells |
R11103 | T16825 | T16826 | nsubj | cells,are |
R11104 | T16826 | T16826 | ROOT | are,are |
R11105 | T16827 | T16826 | acomp | hyper-responsive,are |
R11106 | T16828 | T16827 | prep | to,hyper-responsive |
R11107 | T16829 | T16828 | pobj | TNF,to |
R11108 | T16830 | T16826 | punct | ",",are |
R11109 | T16831 | T16826 | prep | with,are |
R11110 | T16832 | T16833 | amod | enhanced,proliferation |
R11111 | T16833 | T16831 | pobj | proliferation,with |
R11112 | T16834 | T16833 | cc | and,proliferation |
R11113 | T16835 | T16833 | conj | activation,proliferation |
R11114 | T16836 | T16833 | prep | of,proliferation |
R11115 | T16837 | T16840 | det | the,pathway |
R11116 | T16838 | T16840 | amod | NF-κB,pathway |
R11117 | T16839 | T16840 | amod | signalling,pathway |
R11118 | T16840 | T16836 | pobj | pathway,of |
R11119 | T16841 | T16826 | punct | .,are |
R11120 | T16842 | T16844 | nummod | TRAF1,functions |
R11122 | T16844 | T16844 | ROOT | functions,functions |
R11123 | T16845 | T16844 | prep | as,functions |
R11124 | T16846 | T16848 | det | a,regulator |
R11125 | T16847 | T16848 | amod | negative,regulator |
R11126 | T16848 | T16845 | pobj | regulator,as |
R11127 | T16849 | T16848 | prep | of,regulator |
R11128 | T16850 | T16852 | amod | CD40-induced,activation |
R11129 | T16851 | T16852 | compound | NF-κB,activation |
R11130 | T16852 | T16849 | pobj | activation,of |
R11131 | T16853 | T16844 | punct | .,functions |
R11132 | T16854 | T16856 | amod | TRAF1-deficient,cells |
R11133 | T16855 | T16856 | amod | dendritic,cells |
R11134 | T16856 | T16860 | nsubj | cells,show |
R11135 | T16857 | T16860 | punct | ",",show |
R11136 | T16858 | T16860 | advmod | however,show |
R11137 | T16859 | T16860 | punct | ",",show |
R11138 | T16860 | T16860 | ROOT | show,show |
R11139 | T16861 | T16862 | amod | attenuated,responses |
R11140 | T16862 | T16860 | dobj | responses,show |
R11141 | T16863 | T16862 | prep | to,responses |
R11142 | T16864 | T16865 | amod | secondary,stimulation |
R11143 | T16865 | T16863 | pobj | stimulation,to |
R11144 | T16866 | T16862 | prep | by,responses |
R11145 | T16867 | T16868 | amod | TRAF2-dependent,factors |
R11146 | T16868 | T16866 | pobj | factors,by |
R11147 | T16869 | T16862 | punct | ",",responses |
R11148 | T16870 | T16860 | advcl | suggesting,show |
R11149 | T16871 | T16874 | det | a,role |
R11150 | T16872 | T16874 | amod | positive,role |
R11151 | T16873 | T16874 | amod | regulatory,role |
R11152 | T16874 | T16870 | dobj | role,suggesting |
R11153 | T16875 | T16874 | prep | in,role |
R11154 | T16876 | T16877 | det | these,cells |
R11155 | T16877 | T16875 | pobj | cells,in |
R11156 | T16878 | T16860 | punct | .,show |
R11157 | T16879 | T16880 | det | The,mechanism |
R11158 | T16880 | T16889 | nsubj | mechanism,is |
R11159 | T16881 | T16884 | prep | by,modulates |
R11160 | T16882 | T16881 | pobj | which,by |
R11161 | T16883 | T16884 | nsubj | TRAF1,modulates |
R11162 | T16884 | T16880 | relcl | modulates,mechanism |
R11163 | T16885 | T16884 | punct | NF,modulates |
R11164 | T16886 | T16880 | punct | -,mechanism |
R11165 | T16887 | T16888 | compound | κB,activation |
R11166 | T16888 | T16880 | appos | activation,mechanism |
R11167 | T16889 | T16889 | ROOT | is,is |
R11168 | T16890 | T16889 | advmod | still,is |
R11169 | T16891 | T16889 | acomp | unclear,is |
R11170 | T16892 | T16889 | punct | .,is |
R11171 | T16893 | T16894 | advmod | Most,probably |
R11172 | T16894 | T16897 | advmod | probably,competes |
R11173 | T16895 | T16897 | punct | ",",competes |
R11174 | T16896 | T16897 | nsubj | TRAF1,competes |
R11175 | T16897 | T16897 | ROOT | competes,competes |
R11176 | T16898 | T16897 | prep | with,competes |
R11177 | T16899 | T16901 | compound | TRAF,members |
R11178 | T16900 | T16901 | compound | family,members |
R11179 | T16901 | T16898 | pobj | members,with |
R11180 | T16902 | T16897 | prep | for,competes |
R11181 | T16903 | T16902 | amod | binding,for |
R11182 | T16904 | T16903 | prep | to,binding |
R11183 | T16905 | T16906 | det | the,receptor |
R11184 | T16906 | T16904 | pobj | receptor,to |
R11185 | T16907 | T16906 | cc | or,receptor |
R11186 | T16908 | T16910 | amod | other,proteins |
R11187 | T16909 | T16910 | amod | signalling,proteins |
R11188 | T16910 | T16906 | conj | proteins,receptor |
R11189 | T16911 | T16897 | punct | .,competes |
R11190 | T16912 | T16916 | advmod | Alternatively,recruit |
R11191 | T16913 | T16916 | punct | ",",recruit |
R11192 | T16914 | T16916 | nsubj | TRAF1,recruit |
R11193 | T16915 | T16916 | aux | might,recruit |
R11194 | T16916 | T16916 | ROOT | recruit,recruit |
R11195 | T16917 | T16916 | dobj | A20,recruit |
R11196 | T16918 | T16923 | prep | with,interact |
R11197 | T16919 | T16918 | pobj | which,with |
R11198 | T16920 | T16923 | nsubj | it,interact |
R11199 | T16921 | T16923 | aux | can,interact |
R11200 | T16922 | T16923 | advmod | physically,interact |
R11201 | T16923 | T16916 | conj | interact,recruit |
R11202 | T16924 | T16923 | dobj | [,interact |
R11203 | T16925 | T16926 | nummod | 73,] |
R11204 | T16926 | T16924 | appos | ],[ |
R11205 | T16927 | T16916 | punct | .,recruit |
R11206 | T16928 | T16931 | det | A,study |
R11207 | T16929 | T16930 | compound | genome-wide,association |
R11208 | T16930 | T16931 | compound | association,study |
R11209 | T16931 | T16946 | nsubj | study,identified |
R11210 | T16932 | T16931 | acl | examining,study |
R11211 | T16933 | T16935 | amod | more,"300,000" |
R11212 | T16934 | T16935 | quantmod | than,"300,000" |
R11213 | T16935 | T16936 | nummod | "300,000",SNPs |
R11214 | T16936 | T16932 | dobj | SNPs,examining |
R11215 | T16937 | T16932 | prep | among,examining |
R11216 | T16938 | T16939 | advmod | approximately,"1,500" |
R11217 | T16939 | T16942 | nummod | "1,500",cases |
R11218 | T16940 | T16942 | amod | autoantibody-positive,cases |
R11219 | T16941 | T16942 | compound | RA,cases |
R11220 | T16942 | T16937 | pobj | cases,among |
R11221 | T16943 | T16942 | cc | and,cases |
R11222 | T16944 | T16945 | nummod | "1,800",controls |
R11223 | T16945 | T16942 | conj | controls,cases |
R11224 | T16946 | T16946 | ROOT | identified,identified |
R11225 | T16947 | T16949 | det | a,variation |
R11226 | T16948 | T16949 | amod | genetic,variation |
R11227 | T16949 | T16946 | dobj | variation,identified |
R11228 | T16950 | T16946 | prep | at,identified |
R11229 | T16951 | T16953 | det | the,component |
R11230 | T16952 | T16953 | compound | TRAF1-complement,component |
R11231 | T16953 | T16950 | pobj | component,at |
R11232 | T16954 | T16955 | nummod | 5,locus |
R11233 | T16955 | T16946 | npadvmod | locus,identified |
R11234 | T16956 | T16961 | mark | as,locus |
R11235 | T16957 | T16960 | det | an,risk |
R11236 | T16958 | T16960 | amod | important,risk |
R11237 | T16959 | T16960 | compound | RA,risk |
R11238 | T16960 | T16961 | nsubj | risk,locus |
R11239 | T16961 | T16946 | advcl | locus,identified |
R11240 | T16962 | T16964 | nmod | [,] |
R11241 | T16963 | T16964 | nummod | 74,] |
R11242 | T16964 | T16961 | dobj | ],locus |
R11243 | T16965 | T16946 | punct | .,identified |
R11244 | T16966 | T16967 | amod | Subsequent,work |
R11245 | T16967 | T16968 | nsubj | work,indicates |
R11246 | T16968 | T16968 | ROOT | indicates,indicates |
R11247 | T16969 | T16971 | mark | that,is |
R11248 | T16970 | T16971 | nsubj | TRAF1,is |
R11249 | T16971 | T16968 | ccomp | is,indicates |
R11250 | T16972 | T16973 | advmod | more,likely |
R11251 | T16973 | T16971 | acomp | likely,is |
R11252 | T16974 | T16975 | aux | to,be |
R11253 | T16975 | T16973 | xcomp | be,likely |
R11254 | T16976 | T16978 | det | the,locus |
R11255 | T16977 | T16978 | amod | causative,locus |
R11256 | T16978 | T16975 | attr | locus,be |
R11257 | T16979 | T16981 | nmod | [,] |
R11258 | T16980 | T16981 | nummod | 75,] |
R11259 | T16981 | T16978 | appos | ],locus |
R11260 | T16982 | T16968 | punct | .,indicates |
R11261 | T16983 | T16984 | amod | Recent,work |
R11262 | T16984 | T16990 | nsubj | work,demonstrates |
R11263 | T16985 | T16984 | prep | in,work |
R11264 | T16986 | T16988 | det | a,population |
R11265 | T16987 | T16988 | amod | Korean,population |
R11266 | T16988 | T16985 | pobj | population,in |
R11267 | T16989 | T16990 | advmod | also,demonstrates |
R11268 | T16990 | T16990 | ROOT | demonstrates,demonstrates |
R11269 | T16991 | T16992 | amod | genetic,association |
R11270 | T16992 | T16990 | dobj | association,demonstrates |
R11271 | T16993 | T16992 | prep | of,association |
R11272 | T16994 | T16996 | det | the,region |
R11273 | T16995 | T16996 | nummod | TRAF1,region |
R11274 | T16996 | T16993 | pobj | region,of |
R11275 | T16997 | T16990 | prep | with,demonstrates |
R11276 | T16998 | T16999 | compound | RA,[ |
R11279 | T17001 | T16999 | appos | ],[ |
R11280 | T17002 | T16990 | punct | .,demonstrates |
R11895 | T18039 | T18040 | compound | microRNAs,miRNAs |
R11896 | T18040 | T18043 | nsubjpass | miRNAs,discovered |
R11897 | T18041 | T18043 | auxpass | are,discovered |
R11898 | T18042 | T18043 | advmod | recently,discovered |
R11899 | T18043 | T18043 | ROOT | discovered,discovered |
R11900 | T18044 | T18043 | dobj | regulators,discovered |
R11901 | T18045 | T18044 | prep | of,regulators |
R11902 | T18046 | T18047 | compound | gene,expression |
R11903 | T18047 | T18045 | pobj | expression,of |
R11904 | T18048 | T18043 | cc | and,discovered |
R11905 | T18049 | T18043 | conj | represent,discovered |
R11906 | T18050 | T18051 | det | a,class |
R11907 | T18051 | T18049 | dobj | class,represent |
R11908 | T18052 | T18051 | prep | of,class |
R11909 | T18053 | T18052 | pcomp | noncoding,of |
R11910 | T18054 | T18055 | compound | RNA,molecules |
R11911 | T18055 | T18053 | dobj | molecules,noncoding |
R11912 | T18056 | T18051 | amod | essential,class |
R11913 | T18057 | T18051 | prep | in,class |
R11914 | T18058 | T18062 | amod | many,processes |
R11915 | T18059 | T18062 | amod | cellular,processes |
R11916 | T18060 | T18059 | cc | and,cellular |
R11917 | T18061 | T18059 | conj | developmental,cellular |
R11918 | T18062 | T18057 | pobj | processes,in |
R11919 | T18063 | T18062 | punct | ",",processes |
R11920 | T18064 | T18062 | prep | including,processes |
R11921 | T18065 | T18066 | amod | immune,responses |
R11922 | T18066 | T18064 | pobj | responses,including |
R11923 | T18067 | T18066 | cc | and,responses |
R11924 | T18068 | T18066 | conj | inflammation,responses |
R11925 | T18069 | T18043 | punct | .,discovered |
R11926 | T18070 | T18071 | nsubj | They,bind |
R11927 | T18071 | T18071 | ROOT | bind,bind |
R11928 | T18072 | T18073 | det | the,3 |
R11929 | T18073 | T18076 | meta | 3,UTR |
R11930 | T18074 | T18073 | punct | ',3 |
R11931 | T18075 | T18076 | punct | -,UTR |
R11932 | T18076 | T18071 | dobj | UTR,bind |
R11933 | T18077 | T18076 | prep | of,UTR |
R11934 | T18078 | T18079 | compound | target,mRNAs |
R11935 | T18079 | T18077 | pobj | mRNAs,of |
R11936 | T18080 | T18079 | acl | leading,mRNAs |
R11937 | T18081 | T18080 | prep | to,leading |
R11938 | T18082 | T18083 | det | the,repression |
R11939 | T18083 | T18081 | pobj | repression,to |
R11940 | T18084 | T18083 | prep | of,repression |
R11941 | T18085 | T18086 | compound | protein,expression |
R11942 | T18086 | T18084 | pobj | expression,of |
R11943 | T18087 | T18086 | cc | and,expression |
R11944 | T18088 | T18089 | det | the,promotion |
R11945 | T18089 | T18086 | conj | promotion,expression |
R11946 | T18090 | T18089 | prep | of,promotion |
R11947 | T18091 | T18092 | compound | target,mRNA |
R11948 | T18092 | T18093 | compound | mRNA,degradation |
R11949 | T18093 | T18090 | pobj | degradation,of |
R11950 | T18094 | T18096 | nmod | [,] |
R11951 | T18095 | T18096 | nummod | 77,] |
R11952 | T18096 | T18093 | appos | ],degradation |
R11953 | T18097 | T18071 | punct | .,bind |
R11954 | T18098 | T18100 | amod | miR-146a,b |
R11955 | T18099 | T18100 | compound | /,b |
R11956 | T18100 | T18103 | nsubj | b,are |
R11957 | T18101 | T18100 | cc | and,b |
R11958 | T18102 | T18100 | conj | miR-155,b |
R11959 | T18103 | T18103 | ROOT | are,are |
R11960 | T18104 | T18103 | prep | of,are |
R11961 | T18105 | T18106 | amod | particular,interest |
R11962 | T18106 | T18104 | pobj | interest,of |
R11963 | T18107 | T18103 | prep | for,are |
R11964 | T18108 | T18109 | amod | inflammatory,signalling |
R11965 | T18109 | T18107 | pobj | signalling,for |
R11966 | T18110 | T18109 | prep | to,signalling |
R11967 | T18111 | T18110 | pobj | NF-κB,to |
R11968 | T18112 | T18103 | punct | ",",are |
R11969 | T18113 | T18118 | mark | since,induced |
R11970 | T18114 | T18115 | det | these,miRNAs |
R11971 | T18115 | T18118 | nsubjpass | miRNAs,induced |
R11972 | T18116 | T18118 | aux | can,induced |
R11973 | T18117 | T18118 | auxpass | be,induced |
R11974 | T18118 | T18103 | advcl | induced,are |
R11975 | T18119 | T18118 | agent | by,induced |
R11976 | T18120 | T18121 | amod | inflammatory,stimuli |
R11977 | T18121 | T18119 | pobj | stimuli,by |
R11978 | T18122 | T18123 | amod | such,as |
R11979 | T18123 | T18121 | prep | as,stimuli |
R11980 | T18124 | T18123 | pobj | IL-1β,as |
R11981 | T18125 | T18124 | punct | ",",IL-1β |
R11982 | T18126 | T18124 | conj | TNF,IL-1β |
R11983 | T18127 | T18126 | cc | and,TNF |
R11984 | T18128 | T18129 | compound | TLRs,[ |
R11985 | T18129 | T18126 | conj | [,TNF |
R11986 | T18130 | T18131 | compound | "78,79",] |
R11987 | T18131 | T18126 | conj | ],TNF |
R11988 | T18132 | T18103 | punct | .,are |
R11989 | T18133 | T18137 | prep | In,is |
R11990 | T18134 | T18133 | pobj | addition,In |
R11991 | T18135 | T18137 | punct | ",",is |
R11992 | T18136 | T18137 | nsubj | miR-146a,is |
R11993 | T18137 | T18137 | ROOT | is,is |
R11994 | T18138 | T18140 | det | an,gene |
R11995 | T18139 | T18140 | amod | NF-κB-dependent,gene |
R11996 | T18140 | T18137 | attr | gene,is |
R11997 | T18141 | T18137 | punct | ",",is |
R11998 | T18142 | T18137 | cc | and,is |
R11999 | T18143 | T18144 | det | the,NF-κB |
R12000 | T18144 | T18145 | nsubj | NF-κB,signalling |
R12001 | T18145 | T18151 | advcl | signalling,identified |
R12002 | T18146 | T18145 | dobj | molecules,signalling |
R12003 | T18147 | T18151 | nsubjpass | IRAK1,identified |
R12004 | T18148 | T18147 | cc | and,IRAK1 |
R12005 | T18149 | T18147 | conj | TRAF6,IRAK1 |
R12006 | T18150 | T18151 | auxpass | were,identified |
R12007 | T18151 | T18137 | conj | identified,is |
R12008 | T18152 | T18151 | prep | as,identified |
R12009 | T18153 | T18154 | compound | target,genes |
R12010 | T18154 | T18152 | pobj | genes,as |
R12011 | T18155 | T18154 | prep | of,genes |
R12012 | T18156 | T18157 | compound | miR-146a,[ |
R12013 | T18157 | T18155 | pobj | [,of |
R12014 | T18158 | T18159 | nummod | 78,] |
R12015 | T18159 | T18154 | conj | ],genes |
R12016 | T18160 | T18161 | punct | (,Figure |
R12017 | T18161 | T18159 | appos | Figure,] |
R12018 | T18162 | T18161 | nummod | 1,Figure |
R12019 | T18163 | T18159 | punct | ),] |
R12020 | T18164 | T18151 | punct | .,identified |
R12021 | T18165 | T18169 | advmod | Similarly,shown |
R12022 | T18166 | T18169 | punct | ",",shown |
R12023 | T18167 | T18169 | nsubjpass | miR-155,shown |
R12024 | T18168 | T18169 | auxpass | was,shown |
R12025 | T18169 | T18169 | ROOT | shown,shown |
R12026 | T18170 | T18171 | aux | to,target |
R12027 | T18171 | T18169 | xcomp | target,shown |
R12028 | T18172 | T18171 | dobj | transcripts,target |
R12029 | T18173 | T18172 | prep | for,transcripts |
R12030 | T18174 | T18175 | det | the,NF-κB |
R12031 | T18175 | T18176 | nsubj | NF-κB,signalling |
R12032 | T18176 | T18173 | pcomp | signalling,for |
R12033 | T18177 | T18176 | dobj | molecules,signalling |
R12034 | T18178 | T18176 | dobj | IKKε,signalling |
R12035 | T18179 | T18178 | cc | and,IKKε |
R12036 | T18180 | T18181 | compound | RIP1,[ |
R12037 | T18181 | T18178 | conj | [,IKKε |
R12038 | T18182 | T18183 | compound | "79,80",] |
R12039 | T18183 | T18178 | conj | ],IKKε |
R12040 | T18184 | T18169 | punct | .,shown |
R12041 | T18185 | T18192 | advmod | Notably,expressed |
R12042 | T18186 | T18192 | punct | ",",expressed |
R12043 | T18187 | T18188 | preconj | both,miR-146 |
R12044 | T18188 | T18192 | nsubjpass | miR-146,expressed |
R12045 | T18189 | T18188 | cc | and,miR-146 |
R12046 | T18190 | T18188 | conj | miR-155,miR-146 |
R12047 | T18191 | T18192 | auxpass | are,expressed |
R12048 | T18192 | T18192 | ROOT | expressed,expressed |
R12049 | T18193 | T18192 | prep | at,expressed |
R12050 | T18194 | T18195 | amod | higher,levels |
R12051 | T18195 | T18193 | pobj | levels,at |
R12052 | T18196 | T18195 | prep | in,levels |
R12053 | T18197 | T18196 | pobj | RA,in |
R12054 | T18198 | T18199 | amod | synovial,fibroblasts |
R12055 | T18199 | T18195 | conj | fibroblasts,levels |
R12056 | T18200 | T18199 | cc | and,fibroblasts |
R12057 | T18201 | T18202 | amod | synovial,tissue |
R12058 | T18202 | T18205 | compound | tissue,] |
R12059 | T18203 | T18205 | compound | [,] |
R12060 | T18204 | T18205 | compound | "81,82",] |
R12061 | T18205 | T18199 | conj | ],fibroblasts |
R12062 | T18206 | T18205 | punct | ",",] |
R12063 | T18207 | T18209 | advmod | as,as |
R12064 | T18208 | T18209 | advmod | well,as |
R12065 | T18209 | T18193 | cc | as,at |
R12066 | T18210 | T18209 | prep | in,as |
R12067 | T18211 | T18214 | amod | peripheral,cells |
R12068 | T18212 | T18213 | compound | blood,mononuclear |
R12069 | T18213 | T18214 | compound | mononuclear,cells |
R12070 | T18214 | T18210 | pobj | cells,in |
R12071 | T18215 | T18214 | prep | of,cells |
R12072 | T18216 | T18217 | compound | RA,patients |
R12073 | T18217 | T18215 | pobj | patients,of |
R12074 | T18218 | T18220 | nmod | [,] |
R12075 | T18219 | T18220 | nummod | 83,] |
R12076 | T18220 | T18192 | dobj | ],expressed |
R12077 | T18221 | T18192 | punct | .,expressed |
R12078 | T18222 | T18225 | nsubjpass | miR-146a,overexpressed |
R12079 | T18223 | T18225 | auxpass | is,overexpressed |
R12080 | T18224 | T18225 | advmod | also,overexpressed |
R12081 | T18225 | T18225 | ROOT | overexpressed,overexpressed |
R12082 | T18226 | T18225 | prep | in,overexpressed |
R12083 | T18227 | T18228 | compound | CD4,+ |
R12084 | T18228 | T18226 | pobj | +,in |
R12085 | T18229 | T18228 | cc | and,+ |
R12086 | T18230 | T18228 | conj | IL-17-producing,+ |
R12087 | T18231 | T18232 | compound | T,cells |
R12088 | T18232 | T18225 | conj | cells,overexpressed |
R12089 | T18233 | T18232 | prep | from,cells |
R12090 | T18234 | T18235 | compound | RA,patients |
R12091 | T18235 | T18233 | pobj | patients,from |
R12092 | T18236 | T18237 | quantmod | [,"84,85" |
R12093 | T18237 | T18238 | nummod | "84,85",] |
R12094 | T18238 | T18232 | conj | ],cells |
R12095 | T18239 | T18225 | punct | .,overexpressed |
R12096 | T18240 | T18257 | advmod | Interestingly,shown |
R12097 | T18241 | T18257 | punct | ",",shown |
R12098 | T18242 | T18243 | det | a,polymorphism |
R12099 | T18243 | T18257 | nsubjpass | polymorphism,shown |
R12100 | T18244 | T18243 | prep | in,polymorphism |
R12101 | T18245 | T18249 | det | the,UTR |
R12102 | T18246 | T18249 | nummod | 3,UTR |
R12103 | T18247 | T18246 | punct | ',3 |
R12104 | T18248 | T18249 | punct | -,UTR |
R12105 | T18249 | T18244 | pobj | UTR,in |
R12106 | T18250 | T18249 | prep | of,UTR |
R12107 | T18251 | T18254 | det | the,gene |
R12108 | T18252 | T18254 | compound | miR-146a,gene |
R12109 | T18253 | T18254 | compound | target,gene |
R12110 | T18254 | T18250 | pobj | gene,of |
R12111 | T18255 | T18257 | auxpass | was,shown |
R12112 | T18256 | T18257 | advmod | recently,shown |
R12113 | T18257 | T18257 | ROOT | shown,shown |
R12114 | T18258 | T18260 | aux | to,associated |
R12115 | T18259 | T18260 | auxpass | be,associated |
R12116 | T18260 | T18257 | xcomp | associated,shown |
R12117 | T18261 | T18260 | prep | with,associated |
R12118 | T18262 | T18263 | compound | RA,susceptibility |
R12119 | T18263 | T18264 | compound | susceptibility,[ |
R12120 | T18264 | T18261 | pobj | [,with |
R12121 | T18265 | T18266 | nummod | 86,] |
R12122 | T18266 | T18264 | appos | ],[ |
R12123 | T18267 | T18257 | punct | .,shown |
R12124 | T18268 | T18269 | compound | miR-155,overexpression |
R12125 | T18269 | T18273 | nsubj | overexpression,was |
R12127 | T18271 | T18272 | amod | synovial,fibroblasts |
R12128 | T18272 | T18270 | pobj | fibroblasts,in |
R12129 | T18273 | T18273 | ROOT | was,was |
R12130 | T18274 | T18273 | acomp | able,was |
R12131 | T18275 | T18276 | aux | to,prevent |
R12132 | T18276 | T18274 | xcomp | prevent,able |
R12133 | T18277 | T18278 | det | the,TLR |
R12134 | T18278 | T18276 | dobj | TLR,prevent |
R12135 | T18279 | T18278 | cc | and,TLR |
R12136 | T18280 | T18281 | amod | cytokine-inducible,expression |
R12137 | T18281 | T18278 | conj | expression,TLR |
R12138 | T18282 | T18281 | prep | of,expression |
R12139 | T18283 | T18285 | amod | specific,metalloproteinases |
R12140 | T18284 | T18285 | compound | matrix,metalloproteinases |
R12141 | T18285 | T18282 | pobj | metalloproteinases,of |
R12142 | T18286 | T18287 | nsubj | that,mediate |
R12143 | T18287 | T18285 | relcl | mediate,metalloproteinases |
R12144 | T18288 | T18289 | amod | tissue,destruction |
R12145 | T18289 | T18287 | dobj | destruction,mediate |
R12146 | T18290 | T18287 | prep | in,mediate |
R12147 | T18291 | T18292 | compound | RA,[ |
R12148 | T18292 | T18290 | pobj | [,in |
R12149 | T18293 | T18294 | nummod | 81,] |
R12150 | T18294 | T18292 | appos | ],[ |
R12151 | T18295 | T18273 | punct | .,was |
R12152 | T18296 | T18300 | advmod | Moreover,shown |
R12153 | T18297 | T18300 | punct | ",",shown |
R12154 | T18298 | T18300 | nsubjpass | miR-155,shown |
R12155 | T18299 | T18300 | auxpass | was,shown |
R12156 | T18300 | T18300 | ROOT | shown,shown |
R12157 | T18301 | T18302 | aux | to,promote |
R12158 | T18302 | T18300 | xcomp | promote,shown |
R12159 | T18303 | T18304 | compound | TNF,production |
R12160 | T18304 | T18302 | dobj | production,promote |
R12161 | T18305 | T18304 | punct | ",",production |
R12162 | T18306 | T18308 | det | a,process |
R12163 | T18307 | T18308 | amod | key,process |
R12164 | T18308 | T18304 | appos | process,production |
R12165 | T18309 | T18308 | prep | in,process |
R12166 | T18310 | T18311 | det | the,pathogenesis |
R12167 | T18311 | T18309 | pobj | pathogenesis,in |
R12168 | T18312 | T18311 | prep | of,pathogenesis |
R12169 | T18313 | T18314 | compound | RA,[ |
R12170 | T18314 | T18312 | pobj | [,of |
R12171 | T18315 | T18316 | nummod | 87,] |
R12172 | T18316 | T18311 | appos | ],pathogenesis |
R12173 | T18317 | T18300 | punct | .,shown |
R12174 | T18318 | T18323 | nsubj | miR-146,be |
R12175 | T18319 | T18318 | cc | and,miR-146 |
R12176 | T18320 | T18318 | conj | miR-155,miR-146 |
R12177 | T18321 | T18323 | aux | may,be |
R12178 | T18322 | T18323 | advmod | therefore,be |
R12179 | T18323 | T18323 | ROOT | be,be |
R12180 | T18324 | T18326 | amod | important,regulators |
R12181 | T18325 | T18326 | amod | negative,regulators |
R12182 | T18326 | T18323 | attr | regulators,be |
R12183 | T18327 | T18326 | prep | of,regulators |
R12184 | T18328 | T18327 | pobj | inflammation,of |
R12185 | T18329 | T18328 | prep | in,inflammation |
R12186 | T18330 | T18329 | pobj | RA,in |
R12187 | T18331 | T18323 | cc | and,be |
R12188 | T18332 | T18333 | poss | their,potential |
R12189 | T18333 | T18340 | nsubj | potential,is |
R12190 | T18334 | T18333 | prep | for,potential |
R12191 | T18335 | T18336 | det | the,development |
R12192 | T18336 | T18334 | pobj | development,for |
R12193 | T18337 | T18336 | prep | of,development |
R12194 | T18338 | T18339 | amod | new,treatments |
R12195 | T18339 | T18337 | pobj | treatments,of |
R12196 | T18340 | T18323 | conj | is,be |
R12197 | T18341 | T18340 | acomp | substantial,is |
R12198 | T18342 | T18340 | punct | .,is |
R12199 | T18343 | T18352 | prep | In,is |
R12200 | T18344 | T18343 | pobj | addition,In |
R12201 | T18345 | T18352 | punct | ",",is |
R12202 | T18346 | T18348 | poss | their,expression |
R12203 | T18347 | T18348 | amod | increased,expression |
R12204 | T18348 | T18352 | nsubj | expression,is |
R12205 | T18349 | T18348 | prep | in,expression |
R12206 | T18350 | T18351 | compound | RA,patients |
R12207 | T18351 | T18349 | pobj | patients,in |
R12208 | T18352 | T18352 | ROOT | is,is |
R12209 | T18353 | T18354 | advmod | potentially,useful |
R12210 | T18354 | T18352 | acomp | useful,is |
R12211 | T18355 | T18354 | prep | as,useful |
R12212 | T18356 | T18357 | det | a,marker |
R12213 | T18357 | T18355 | pobj | marker,as |
R12214 | T18358 | T18357 | prep | for,marker |
R12215 | T18359 | T18360 | compound | disease,diagnosis |
R12216 | T18360 | T18358 | pobj | diagnosis,for |
R12217 | T18361 | T18360 | punct | ",",diagnosis |
R12218 | T18362 | T18360 | conj | progression,diagnosis |
R12219 | T18363 | T18362 | punct | ",",progression |
R12220 | T18364 | T18362 | cc | or,progression |
R12221 | T18365 | T18366 | compound | treatment,efficacy |
R12222 | T18366 | T18362 | conj | efficacy,progression |
R12223 | T18367 | T18369 | nmod | [,] |
R12224 | T18368 | T18369 | nummod | 88,] |
R12225 | T18369 | T18357 | appos | ],marker |
R12226 | T18370 | T18352 | punct | ",",is |
R12227 | T18371 | T18352 | cc | but,is |
R12228 | T18372 | T18374 | nsubj | this,require |
R12229 | T18373 | T18374 | aux | will,require |
R12230 | T18374 | T18352 | conj | require,is |
R12231 | T18375 | T18374 | dobj | confirmation,require |
R12232 | T18376 | T18374 | advcl | using,require |
R12233 | T18377 | T18381 | det | a,cohort |
R12234 | T18378 | T18381 | amod | large,cohort |
R12235 | T18379 | T18378 | cc | and,large |
R12236 | T18380 | T18378 | conj | well-defined,large |
R12237 | T18381 | T18376 | dobj | cohort,using |
R12238 | T18382 | T18374 | punct | .,require |
R12239 | T18383 | T18409 | prep | Besides,identified |
R12240 | T18384 | T18383 | pobj | miR-146,Besides |
R12241 | T18385 | T18384 | cc | and,miR-146 |
R12242 | T18386 | T18384 | conj | miR-155,miR-146 |
R12243 | T18387 | T18386 | punct | ",",miR-155 |
R12244 | T18388 | T18389 | det | a,number |
R12245 | T18389 | T18386 | appos | number,miR-155 |
R12246 | T18390 | T18389 | prep | of,number |
R12247 | T18391 | T18392 | amod | other,miRNAs |
R12248 | T18392 | T18390 | pobj | miRNAs,of |
R12249 | T18393 | T18389 | prep | with,number |
R12250 | T18394 | T18396 | det | a,role |
R12251 | T18395 | T18396 | amod | potential,role |
R12252 | T18396 | T18393 | pobj | role,with |
R12253 | T18397 | T18396 | prep | in,role |
R12254 | T18398 | T18399 | det | the,control |
R12255 | T18399 | T18397 | pobj | control,in |
R12256 | T18400 | T18399 | prep | of,control |
R12257 | T18401 | T18403 | amod | NF-κB-dependent,responses |
R12258 | T18402 | T18403 | amod | inflammatory,responses |
R12259 | T18403 | T18400 | pobj | responses,of |
R12260 | T18404 | T18403 | prep | in,responses |
R12261 | T18405 | T18406 | compound | RA,pathology |
R12262 | T18406 | T18404 | pobj | pathology,in |
R12263 | T18407 | T18409 | auxpass | were,identified |
R12264 | T18408 | T18409 | advmod | recently,identified |
R12265 | T18409 | T18409 | ROOT | identified,identified |
R12266 | T18410 | T18409 | punct | .,identified |
R12267 | T18411 | T18411 | ROOT | In,In |
R12268 | T18412 | T18413 | det | this,context |
R12269 | T18413 | T18411 | pobj | context,In |
R12270 | T18414 | T18411 | punct | ",",In |
R12271 | T18415 | T18411 | conj | miR-124a,In |
R12272 | T18416 | T18415 | punct | -,miR-124a |
R12273 | T18417 | T18419 | det | a,regulator |
R12274 | T18418 | T18419 | amod | key,regulator |
R12275 | T18419 | T18415 | appos | regulator,miR-124a |
R12276 | T18420 | T18419 | prep | of,regulator |
R12277 | T18421 | T18425 | det | the,protein |
R12278 | T18422 | T18425 | nmod | chemokine,protein |
R12279 | T18423 | T18425 | nmod | monocyte,protein |
R12280 | T18424 | T18425 | compound | chemoattractant,protein |
R12281 | T18425 | T18420 | pobj | protein,of |
R12282 | T18426 | T18429 | meta | 1,shown |
R12283 | T18427 | T18429 | punct | -,shown |
R12284 | T18428 | T18429 | auxpass | was,shown |
R12285 | T18429 | T18429 | ROOT | shown,shown |
R12286 | T18430 | T18432 | aux | to,decreased |
R12287 | T18431 | T18432 | auxpass | be,decreased |
R12288 | T18432 | T18429 | xcomp | decreased,shown |
R12289 | T18433 | T18432 | prep | in,decreased |
R12290 | T18434 | T18433 | pobj | synoviocytes,in |
R12291 | T18435 | T18434 | prep | from,synoviocytes |
R12292 | T18436 | T18437 | compound | RA,patients |
R12293 | T18437 | T18435 | pobj | patients,from |
R12294 | T18438 | T18440 | nmod | [,] |
R12295 | T18439 | T18440 | nummod | 89,] |
R12296 | T18440 | T18437 | appos | ],patients |
R12297 | T18441 | T18429 | punct | .,shown |
R12298 | T18442 | T18460 | advmod | Similarly,detected |
R12299 | T18443 | T18460 | punct | ",",detected |
R12300 | T18444 | T18445 | amod | elevated,levels |
R12301 | T18445 | T18460 | nsubjpass | levels,detected |
R12302 | T18446 | T18445 | prep | of,levels |
R12303 | T18447 | T18446 | pobj | miR-203,of |
R12304 | T18448 | T18449 | punct | -,leading |
R12305 | T18449 | T18445 | acl | leading,levels |
R12306 | T18450 | T18449 | prep | to,leading |
R12307 | T18451 | T18452 | amod | increased,secretion |
R12308 | T18452 | T18450 | pobj | secretion,to |
R12309 | T18453 | T18452 | prep | of,secretion |
R12310 | T18454 | T18455 | compound | matrix,metalloproteinase-1 |
R12311 | T18455 | T18453 | pobj | metalloproteinase-1,of |
R12312 | T18456 | T18455 | cc | and,metalloproteinase-1 |
R12313 | T18457 | T18455 | conj | IL-6,metalloproteinase-1 |
R12314 | T18458 | T18460 | punct | -,detected |
R12315 | T18459 | T18460 | auxpass | were,detected |
R12316 | T18460 | T18460 | ROOT | detected,detected |
R12317 | T18461 | T18460 | prep | in,detected |
R12318 | T18462 | T18464 | nmod | RA,fibroblasts |
R12319 | T18463 | T18464 | compound | synovial,fibroblasts |
R12320 | T18464 | T18465 | compound | fibroblasts,[ |
R12321 | T18465 | T18461 | pobj | [,in |
R12322 | T18466 | T18467 | nummod | 90,] |
R12323 | T18467 | T18465 | appos | ],[ |
R12324 | T18468 | T18460 | punct | .,detected |
R12325 | T18469 | T18479 | advmod | Finally,shown |
R12326 | T18470 | T18479 | punct | ",",shown |
R12327 | T18471 | T18479 | nsubjpass | miR-16,shown |
R12328 | T18472 | T18471 | punct | ",",miR-16 |
R12329 | T18473 | T18471 | conj | miR-132,miR-16 |
R12330 | T18474 | T18473 | punct | ",",miR-132 |
R12331 | T18475 | T18473 | cc | and,miR-132 |
R12332 | T18476 | T18473 | conj | miR-223,miR-132 |
R12333 | T18477 | T18479 | auxpass | were,shown |
R12334 | T18478 | T18479 | advmod | also,shown |
R12335 | T18479 | T18479 | ROOT | shown,shown |
R12336 | T18480 | T18481 | aux | to,have |
R12337 | T18481 | T18479 | xcomp | have,shown |
R12338 | T18482 | T18484 | det | an,expression |
R12339 | T18483 | T18484 | amod | altered,expression |
R12340 | T18484 | T18481 | dobj | expression,have |
R12341 | T18485 | T18484 | prep | in,expression |
R12342 | T18486 | T18487 | compound | RA,patients |
R12343 | T18487 | T18485 | pobj | patients,in |
R12344 | T18488 | T18479 | punct | ",",shown |
R12345 | T18489 | T18479 | advcl | indicating,shown |
R12346 | T18490 | T18491 | poss | their,potential |
R12347 | T18491 | T18489 | dobj | potential,indicating |
R12348 | T18492 | T18491 | prep | as,potential |
R12349 | T18493 | T18494 | amod | diagnostic,biomarkers |
R12350 | T18494 | T18492 | pobj | biomarkers,as |
R12351 | T18495 | T18494 | prep | for,biomarkers |
R12352 | T18496 | T18495 | pobj | pathogenesis,for |
R12353 | T18497 | T18499 | compound | [,] |
R12354 | T18498 | T18499 | compound | "83,88,91",] |
R12355 | T18499 | T18491 | appos | ],potential |
R12356 | T18500 | T18479 | punct | .,shown |
R12606 | T19050 | T19052 | det | The,family |
R12607 | T19051 | T19052 | compound | NF-κB,family |
R12608 | T19052 | T19056 | nsubj | family,plays |
R12609 | T19053 | T19052 | prep | of,family |
R12610 | T19054 | T19055 | compound | transcription,factors |
R12611 | T19055 | T19053 | pobj | factors,of |
R12612 | T19056 | T19056 | ROOT | plays,plays |
R12613 | T19057 | T19058 | amod | crucial,roles |
R12614 | T19058 | T19056 | dobj | roles,plays |
R12615 | T19059 | T19056 | prep | in,plays |
R12616 | T19060 | T19062 | det | the,processes |
R12617 | T19061 | T19062 | amod | inflammatory,processes |
R12618 | T19062 | T19059 | pobj | processes,in |
R12619 | T19063 | T19062 | prep | in,processes |
R12620 | T19064 | T19063 | pobj | RA,in |
R12621 | T19065 | T19056 | advcl | leading,plays |
R12622 | T19066 | T19065 | prep | to,leading |
R12623 | T19067 | T19066 | pobj | cartilage,to |
R12624 | T19068 | T19067 | cc | and,cartilage |
R12625 | T19069 | T19070 | compound | bone,destruction |
R12626 | T19070 | T19067 | conj | destruction,cartilage |
R12627 | T19071 | T19056 | punct | .,plays |
R12628 | T19072 | T19079 | csubj | Keeping,be |
R12629 | T19073 | T19074 | amod | NF-κB,activation |
R12630 | T19074 | T19072 | dobj | activation,Keeping |
R12631 | T19075 | T19074 | prep | under,activation |
R12632 | T19076 | T19075 | pobj | control,under |
R12633 | T19077 | T19079 | aux | can,be |
R12634 | T19078 | T19079 | advmod | thus,be |
R12635 | T19079 | T19079 | ROOT | be,be |
R12636 | T19080 | T19081 | advmod | very,important |
R12637 | T19081 | T19079 | acomp | important,be |
R12638 | T19082 | T19079 | prep | for,be |
R12639 | T19083 | T19084 | det | the,design |
R12640 | T19084 | T19082 | pobj | design,for |
R12641 | T19085 | T19084 | prep | of,design |
R12642 | T19086 | T19087 | amod | specific,therapeutics |
R12643 | T19087 | T19085 | pobj | therapeutics,of |
R12644 | T19088 | T19079 | punct | .,be |
R12645 | T19089 | T19090 | det | The,existence |
R12646 | T19090 | T19106 | nsubj | existence,raises |
R12647 | T19091 | T19090 | prep | of,existence |
R12648 | T19092 | T19094 | amod | multiple,regulators |
R12649 | T19093 | T19094 | amod | negative,regulators |
R12650 | T19094 | T19091 | pobj | regulators,of |
R12651 | T19095 | T19090 | acl | ensuring,existence |
R12652 | T19096 | T19098 | det | a,regulation |
R12653 | T19097 | T19098 | amod | tight,regulation |
R12654 | T19098 | T19095 | dobj | regulation,ensuring |
R12655 | T19099 | T19098 | prep | of,regulation |
R12656 | T19100 | T19102 | det | the,pathway |
R12657 | T19101 | T19102 | compound | NF-κB,pathway |
R12658 | T19102 | T19099 | pobj | pathway,of |
R12659 | T19103 | T19098 | punct | ",",regulation |
R12660 | T19104 | T19106 | advmod | however,raises |
R12661 | T19105 | T19106 | punct | ",",raises |
R12662 | T19106 | T19106 | ROOT | raises,raises |
R12663 | T19107 | T19108 | det | the,question |
R12664 | T19108 | T19106 | dobj | question,raises |
R12665 | T19109 | T19108 | prep | of,question |
R12666 | T19110 | T19112 | det | the,role |
R12667 | T19111 | T19112 | amod | specific,role |
R12668 | T19112 | T19109 | pobj | role,of |
R12669 | T19113 | T19112 | prep | of,role |
R12670 | T19114 | T19113 | pobj | each,of |
R12671 | T19115 | T19114 | prep | of,each |
R12672 | T19116 | T19117 | det | these,regulators |
R12673 | T19117 | T19115 | pobj | regulators,of |
R12674 | T19118 | T19114 | cc | and,each |
R12675 | T19119 | T19120 | det | the,relationship |
R12676 | T19120 | T19106 | dobj | relationship,raises |
R12677 | T19121 | T19120 | prep | between,relationship |
R12678 | T19122 | T19121 | pobj | them,between |
R12679 | T19123 | T19106 | punct | .,raises |
R12680 | T19124 | T19145 | prep | In,expected |
R12681 | T19125 | T19124 | pobj | addition,In |
R12682 | T19126 | T19145 | punct | ",",expected |
R12683 | T19127 | T19145 | prep | given,expected |
R12684 | T19128 | T19129 | det | the,number |
R12685 | T19129 | T19127 | pobj | number,given |
R12686 | T19130 | T19129 | prep | of,number |
R12687 | T19131 | T19130 | pobj | miRNAs,of |
R12688 | T19132 | T19131 | prep | in,miRNAs |
R12689 | T19133 | T19132 | pobj | humans,in |
R12690 | T19134 | T19129 | cc | and,number |
R12691 | T19135 | T19137 | det | the,mRNAs |
R12692 | T19136 | T19137 | amod | multiple,mRNAs |
R12693 | T19137 | T19129 | conj | mRNAs,number |
R12694 | T19138 | T19139 | nsubj | they,target |
R12695 | T19139 | T19137 | relcl | target,mRNAs |
R12696 | T19140 | T19145 | punct | ",",expected |
R12697 | T19141 | T19142 | amod | intense,complexity |
R12698 | T19142 | T19145 | nsubjpass | complexity,expected |
R12699 | T19143 | T19145 | aux | can,expected |
R12700 | T19144 | T19145 | auxpass | be,expected |
R12701 | T19145 | T19145 | ROOT | expected,expected |
R12702 | T19146 | T19145 | punct | .,expected |
R12703 | T19147 | T19154 | advmod | How,regulated |
R12704 | T19148 | T19151 | predet | all,signals |
R12705 | T19149 | T19151 | det | these,signals |
R12706 | T19150 | T19151 | amod | regulatory,signals |
R12707 | T19151 | T19154 | nsubjpass | signals,regulated |
R12708 | T19152 | T19154 | auxpass | are,regulated |
R12709 | T19153 | T19154 | npadvmod | themselves,regulated |
R12710 | T19154 | T19156 | csubj | regulated,be |
R12711 | T19155 | T19156 | aux | will,be |
R12712 | T19156 | T19156 | ROOT | be,be |
R12713 | T19157 | T19159 | det | an,question |
R12714 | T19158 | T19159 | amod | important,question |
R12715 | T19159 | T19156 | attr | question,be |
R12716 | T19160 | T19156 | prep | in,be |
R12717 | T19161 | T19160 | pobj | order,in |
R12718 | T19162 | T19163 | aux | to,clarify |
R12719 | T19163 | T19161 | acl | clarify,order |
R12720 | T19164 | T19167 | advmod | how,is |
R12721 | T19165 | T19167 | acomp | NF-κB,is |
R12722 | T19166 | T19167 | nsubj | signalling,is |
R12723 | T19167 | T19163 | ccomp | is,clarify |
R12724 | T19168 | T19167 | attr | organised,is |
R12725 | T19169 | T19167 | punct | ",",is |
R12726 | T19170 | T19167 | cc | and,is |
R12727 | T19171 | T19167 | punct | ",",is |
R12728 | T19172 | T19173 | advmod | more,importantly |
R12729 | T19173 | T19179 | advmod | importantly,lead |
R12730 | T19174 | T19179 | punct | ",",lead |
R12731 | T19175 | T19179 | advmod | how,lead |
R12732 | T19176 | T19177 | det | this,knowledge |
R12733 | T19177 | T19179 | nsubj | knowledge,lead |
R12734 | T19178 | T19179 | aux | may,lead |
R12735 | T19179 | T19156 | advcl | lead,be |
R12736 | T19180 | T19179 | prep | to,lead |
R12737 | T19181 | T19182 | amod | new,treatments |
R12738 | T19182 | T19180 | pobj | treatments,to |
R12739 | T19183 | T19182 | prep | for,treatments |
R12740 | T19184 | T19185 | amod | inflammatory,diseases |
R12741 | T19185 | T19183 | pobj | diseases,for |
R12742 | T19186 | T19187 | amod | such,as |
R12743 | T19187 | T19185 | prep | as,diseases |
R12744 | T19188 | T19187 | pobj | RA,as |
R12745 | T19189 | T19156 | punct | .,be |
R13295 | T20179 | T20180 | compound | Canonical,NF-κB |
R13296 | T20180 | T20181 | nsubj | NF-κB,signalling |
R13297 | T20181 | T20181 | ROOT | signalling,signalling |
R13300 | T20184 | T20181 | dobj | regulators,signalling |
R13301 | T20185 | T20181 | punct | .,signalling |
R13302 | T20186 | T20187 | compound | Ligand,engagement |
R13303 | T20187 | T20202 | dep | engagement,trigger |
R13304 | T20188 | T20187 | prep | of,engagement |
R13305 | T20189 | T20191 | amod | specific,receptors |
R13306 | T20190 | T20191 | compound | membrane,receptors |
R13307 | T20191 | T20188 | pobj | receptors,of |
R13308 | T20192 | T20193 | amod | such,as |
R13309 | T20193 | T20191 | prep | as,receptors |
R13310 | T20194 | T20193 | pobj | TNFR1,as |
R13311 | T20195 | T20194 | punct | ",",TNFR1 |
R13312 | T20196 | T20202 | nsubj | CD40,trigger |
R13313 | T20197 | T20196 | punct | ",",CD40 |
R13314 | T20198 | T20196 | conj | RANK,CD40 |
R13315 | T20199 | T20198 | punct | ",",RANK |
R13316 | T20200 | T20198 | cc | and,RANK |
R13317 | T20201 | T20202 | nummod | TLR4,trigger |
R13318 | T20202 | T20202 | ROOT | trigger,trigger |
R13319 | T20203 | T20204 | det | the,recruitment |
R13320 | T20204 | T20202 | dobj | recruitment,trigger |
R13321 | T20205 | T20204 | prep | of,recruitment |
R13322 | T20206 | T20208 | amod | specific,proteins |
R13323 | T20207 | T20208 | compound | adaptor,proteins |
R13324 | T20208 | T20205 | pobj | proteins,of |
R13325 | T20209 | T20208 | punct | (,proteins |
R13326 | T20210 | T20215 | compound | TNF,protein |
R13327 | T20211 | T20215 | compound | receptor,protein |
R13328 | T20212 | T20214 | amod | 1-associated,domain |
R13329 | T20213 | T20214 | compound | death,domain |
R13330 | T20214 | T20215 | compound | domain,protein |
R13331 | T20215 | T20208 | appos | protein,proteins |
R13332 | T20216 | T20217 | punct | (,TRADD |
R13333 | T20217 | T20215 | appos | TRADD,protein |
R13334 | T20218 | T20217 | punct | ),TRADD |
R13335 | T20219 | T20215 | punct | ",",protein |
R13336 | T20220 | T20215 | appos | MyD88,protein |
R13337 | T20221 | T20220 | punct | ",",MyD88 |
R13338 | T20222 | T20220 | conj | MAL,MyD88 |
R13339 | T20223 | T20222 | punct | ",",MAL |
R13340 | T20224 | T20227 | compound | TIR,IFNβ |
R13341 | T20225 | T20227 | compound | domain-containing,IFNβ |
R13342 | T20226 | T20227 | compound | adaptor-inducing,IFNβ |
R13343 | T20227 | T20222 | conj | IFNβ,MAL |
R13344 | T20228 | T20229 | punct | (,TRIF |
R13345 | T20229 | T20227 | appos | TRIF,IFNβ |
R13346 | T20230 | T20229 | punct | ),TRIF |
R13347 | T20231 | T20227 | punct | ),IFNβ |
R13348 | T20232 | T20227 | punct | ",",IFNβ |
R13349 | T20233 | T20227 | conj | kinases,IFNβ |
R13350 | T20234 | T20233 | punct | (,kinases |
R13351 | T20235 | T20233 | appos | RIP1,kinases |
R13352 | T20236 | T20233 | punct | ",",kinases |
R13353 | T20237 | T20233 | conj | IRAK1,kinases |
R13354 | T20238 | T20237 | punct | ",",IRAK1 |
R13355 | T20239 | T20237 | conj | IRAK4,IRAK1 |
R13356 | T20240 | T20237 | punct | ),IRAK1 |
R13357 | T20241 | T20237 | punct | ",",IRAK1 |
R13358 | T20242 | T20237 | cc | and,IRAK1 |
R13359 | T20243 | T20244 | compound | ubiquitin,ligases |
R13360 | T20244 | T20237 | conj | ligases,IRAK1 |
R13361 | T20245 | T20244 | punct | (,ligases |
R13362 | T20246 | T20244 | appos | TRAF2,ligases |
R13363 | T20247 | T20246 | punct | ",",TRAF2 |
R13364 | T20248 | T20246 | conj | TRAF6,TRAF2 |
R13365 | T20249 | T20244 | punct | ",",ligases |
R13366 | T20250 | T20244 | conj | cIAP1,ligases |
R13367 | T20251 | T20250 | punct | ",",cIAP1 |
R13368 | T20252 | T20250 | conj | cIAP2,cIAP1 |
R13369 | T20253 | T20227 | punct | ),IFNβ |
R13370 | T20254 | T20204 | prep | to,recruitment |
R13371 | T20255 | T20256 | det | the,receptor |
R13372 | T20256 | T20254 | pobj | receptor,to |
R13373 | T20257 | T20202 | punct | .,trigger |
R13374 | T20258 | T20259 | amod | K63-linked,polyubiquitination |
R13375 | T20259 | T20268 | nsubjpass | polyubiquitination,recognised |
R13380 | T20264 | T20263 | cc | and,RIP1 |
R13381 | T20265 | T20263 | conj | IRAK1,RIP1 |
R13382 | T20266 | T20268 | punct | ",",recognised |
R13383 | T20267 | T20268 | auxpass | is,recognised |
R13384 | T20268 | T20268 | ROOT | recognised,recognised |
R13385 | T20269 | T20268 | agent | by,recognised |
R13386 | T20270 | T20269 | pobj | NEMO,by |
R13387 | T20271 | T20270 | cc | and,NEMO |
R13388 | T20272 | T20270 | conj | TAB,NEMO |
R13389 | T20273 | T20268 | advcl | proteins,recognised |
R13390 | T20274 | T20268 | punct | ",",recognised |
R13391 | T20275 | T20268 | advcl | resulting,recognised |
R13392 | T20276 | T20275 | prep | in,resulting |
R13393 | T20277 | T20278 | det | the,recruitment |
R13394 | T20278 | T20276 | pobj | recruitment,in |
R13395 | T20279 | T20278 | cc | and,recruitment |
R13396 | T20280 | T20278 | conj | activation,recruitment |
R13397 | T20281 | T20278 | prep | of,recruitment |
R13398 | T20282 | T20283 | advmod | respectively,IKK2 |
R13399 | T20283 | T20275 | npadvmod | IKK2,resulting |
R13400 | T20284 | T20283 | cc | and,IKK2 |
R13401 | T20285 | T20283 | conj | TAK1,IKK2 |
R13402 | T20286 | T20268 | punct | .,recognised |
R13403 | T20287 | T20289 | nummod | TAK1,phosphorylates |
R13404 | T20288 | T20289 | advmod | then,phosphorylates |
R13405 | T20289 | T20289 | ROOT | phosphorylates,phosphorylates |
R13406 | T20290 | T20289 | cc | and,phosphorylates |
R13407 | T20291 | T20289 | conj | activates,phosphorylates |
R13408 | T20292 | T20291 | dobj | IKK2,activates |
R13409 | T20293 | T20292 | punct | ",",IKK2 |
R13410 | T20294 | T20300 | dep | which,triggering |
R13411 | T20295 | T20294 | prep | in,which |
R13412 | T20296 | T20295 | pobj | turn,in |
R13413 | T20297 | T20298 | compound | phosphorylates,IκBα |
R13414 | T20298 | T20295 | pobj | IκBα,in |
R13415 | T20299 | T20300 | punct | ",",triggering |
R13416 | T20300 | T20291 | advcl | triggering,activates |
R13417 | T20301 | T20303 | poss | its,ubiquitination |
R13418 | T20302 | T20303 | compound | K48-linked,ubiquitination |
R13419 | T20303 | T20300 | dobj | ubiquitination,triggering |
R13420 | T20304 | T20303 | cc | and,ubiquitination |
R13421 | T20305 | T20306 | amod | proteasomal,degradation |
R13422 | T20306 | T20303 | conj | degradation,ubiquitination |
R13423 | T20307 | T20289 | punct | .,phosphorylates |
R13424 | T20308 | T20309 | nsubj | This,allows |
R13425 | T20309 | T20309 | ROOT | allows,allows |
R13426 | T20310 | T20309 | dobj | NF-κB,allows |
R13427 | T20311 | T20313 | punct | (,shown |
R13428 | T20312 | T20313 | advmod | here,shown |
R13429 | T20313 | T20310 | parataxis | shown,NF-κB |
R13430 | T20314 | T20313 | prep | as,shown |
R13431 | T20315 | T20316 | det | a,heterodimer |
R13432 | T20316 | T20314 | pobj | heterodimer,as |
R13433 | T20317 | T20316 | prep | of,heterodimer |
R13434 | T20318 | T20317 | pobj | p65,of |
R13435 | T20319 | T20318 | cc | and,p65 |
R13436 | T20320 | T20318 | conj | p50,p65 |
R13437 | T20321 | T20313 | punct | ),shown |
R13438 | T20322 | T20310 | advmod | to,NF-κB |
R13439 | T20323 | T20322 | pobj | translocate,to |
R13440 | T20324 | T20323 | prep | to,translocate |
R13441 | T20325 | T20326 | det | the,nucleus |
R13442 | T20326 | T20324 | pobj | nucleus,to |
R13443 | T20327 | T20323 | cc | and,translocate |
R13444 | T20328 | T20323 | conj | promote,translocate |
R13445 | T20329 | T20330 | compound | target,gene |
R13446 | T20330 | T20331 | compound | gene,expression |
R13447 | T20331 | T20328 | dobj | expression,promote |
R13448 | T20332 | T20309 | punct | .,allows |
R13449 | T20333 | T20344 | dep | TRAF1,regulate |
R13450 | T20334 | T20333 | punct | ",",TRAF1 |
R13451 | T20335 | T20336 | nsubj | which,has |
R13452 | T20336 | T20333 | relcl | has,TRAF1 |
R13453 | T20337 | T20340 | det | no,activity |
R13454 | T20338 | T20340 | compound | ubiquitin,activity |
R13455 | T20339 | T20340 | compound | ligase,activity |
R13456 | T20340 | T20336 | dobj | activity,has |
R13457 | T20341 | T20344 | punct | ",",regulate |
R13458 | T20342 | T20344 | aux | can,regulate |
R13459 | T20343 | T20344 | advmod | negatively,regulate |
R13460 | T20344 | T20344 | ROOT | regulate,regulate |
R13461 | T20345 | T20346 | amod | NF-κB,activation |
R13462 | T20346 | T20344 | dobj | activation,regulate |
R13463 | T20347 | T20344 | punct | ",",regulate |
R13464 | T20348 | T20349 | advmod | most,probably |
R13465 | T20349 | T20350 | advmod | probably,by |
R13466 | T20350 | T20344 | prep | by,regulate |
R13467 | T20351 | T20350 | pcomp | competing,by |
R13468 | T20352 | T20351 | prep | with,competing |
R13469 | T20353 | T20354 | amod | other,TRAFs |
R13470 | T20354 | T20352 | pobj | TRAFs,with |
R13471 | T20355 | T20344 | punct | .,regulate |
R13472 | T20356 | T20360 | nsubj | A20,deubiquitinating |
R13473 | T20357 | T20356 | cc | and,A20 |
R13474 | T20358 | T20356 | conj | CYLD,A20 |
R13475 | T20359 | T20360 | aux | are,deubiquitinating |
R13476 | T20360 | T20360 | ROOT | deubiquitinating,deubiquitinating |
R13477 | T20361 | T20360 | dobj | enzymes,deubiquitinating |
R13478 | T20362 | T20363 | nsubj | that,control |
R13479 | T20363 | T20361 | relcl | control,enzymes |
R13480 | T20364 | T20365 | amod | NF-κB,activation |
R13481 | T20365 | T20363 | dobj | activation,control |
R13482 | T20366 | T20363 | prep | by,control |
R13483 | T20367 | T20366 | pcomp | targeting,by |
R13484 | T20368 | T20370 | amod | specific,proteins |
R13485 | T20369 | T20370 | amod | signalling,proteins |
R13486 | T20370 | T20367 | dobj | proteins,targeting |
R13487 | T20371 | T20370 | prep | including,proteins |
R13488 | T20372 | T20371 | pobj | RIP1,including |
R13489 | T20373 | T20372 | cc | and,RIP1 |
R13490 | T20374 | T20372 | conj | TRAF6,RIP1 |
R13491 | T20375 | T20370 | punct | ",",proteins |
R13492 | T20376 | T20380 | prep | to,recruited |
R13493 | T20377 | T20376 | pobj | which,to |
R13494 | T20378 | T20380 | nsubjpass | they,recruited |
R13495 | T20379 | T20380 | auxpass | are,recruited |
R13496 | T20380 | T20367 | ccomp | recruited,targeting |
R13497 | T20381 | T20380 | advcl | using,recruited |
R13498 | T20382 | T20385 | amod | specific,proteins |
R13499 | T20383 | T20385 | amod | ubiquitin-binding,proteins |
R13500 | T20384 | T20385 | compound | adaptor,proteins |
R13501 | T20385 | T20381 | dobj | proteins,using |
R13502 | T20386 | T20387 | amod | such,as |
R13503 | T20387 | T20385 | prep | as,proteins |
R13504 | T20388 | T20387 | pobj | ABIN-1,as |
R13505 | T20389 | T20388 | cc | and,ABIN-1 |
R13506 | T20390 | T20388 | conj | p62,ABIN-1 |
R13507 | T20391 | T20360 | punct | .,deubiquitinating |
R13508 | T20392 | T20394 | nsubjpass | miR-146,thought |
R13509 | T20393 | T20394 | auxpass | is,thought |
R13510 | T20394 | T20394 | ROOT | thought,thought |
R13511 | T20395 | T20397 | aux | to,regulate |
R13512 | T20396 | T20397 | advmod | negatively,regulate |
R13513 | T20397 | T20394 | xcomp | regulate,thought |
R13514 | T20398 | T20397 | dobj | TLR,regulate |
R13515 | T20399 | T20397 | oprd | signalling,regulate |
R13516 | T20400 | T20397 | prep | by,regulate |
R13517 | T20401 | T20400 | pcomp | inhibiting,by |
R13518 | T20402 | T20401 | dobj | expression,inhibiting |
R13519 | T20403 | T20402 | prep | of,expression |
R13520 | T20404 | T20403 | pobj | IRAK1,of |
R13521 | T20405 | T20404 | cc | and,IRAK1 |
R13522 | T20406 | T20404 | conj | TRAF6,IRAK1 |
R13523 | T20407 | T20394 | punct | .,thought |
R13524 | T20408 | T20415 | advmod | Finally,inhibited |
R13525 | T20409 | T20415 | punct | ",",inhibited |
R13526 | T20410 | T20411 | compound | TLR,signalling |
R13527 | T20411 | T20415 | nsubjpass | signalling,inhibited |
R13528 | T20412 | T20415 | aux | can,inhibited |
R13529 | T20413 | T20415 | advmod | also,inhibited |
R13530 | T20414 | T20415 | auxpass | be,inhibited |
R13531 | T20415 | T20415 | ROOT | inhibited,inhibited |
R13532 | T20416 | T20415 | agent | by,inhibited |
R13533 | T20417 | T20419 | det | the,protein |
R13534 | T20418 | T20419 | compound | transmembrane,protein |
R13535 | T20419 | T20416 | pobj | protein,by |
R13536 | T20420 | T20419 | appos | SIGIRR,protein |
R13537 | T20421 | T20419 | punct | ",",protein |
R13538 | T20422 | T20425 | nsubjpass | which,proposed |
R13539 | T20423 | T20425 | aux | has,proposed |
R13540 | T20424 | T20425 | auxpass | been,proposed |
R13541 | T20425 | T20419 | relcl | proposed,protein |
R13542 | T20426 | T20427 | aux | to,compete |
R13543 | T20427 | T20425 | xcomp | compete,proposed |
R13544 | T20428 | T20427 | prep | with,compete |
R13545 | T20429 | T20428 | pobj | TLR4,with |
R13546 | T20430 | T20429 | prep | for,TLR4 |
R13547 | T20431 | T20430 | amod | binding,for |
R13548 | T20432 | T20431 | prep | to,binding |
R13549 | T20433 | T20432 | pobj | IRAK1,to |
R13550 | T20434 | T20433 | cc | and,IRAK1 |
R13551 | T20435 | T20433 | conj | TRAF6,IRAK1 |
R13552 | T20436 | T20415 | punct | .,inhibited |
R13553 | T20437 | T20438 | det | The,expression |
R13554 | T20438 | T20446 | nsubj | expression,is |
R13555 | T20439 | T20438 | prep | of,expression |
R13556 | T20440 | T20439 | pobj | many,of |
R13557 | T20441 | T20440 | prep | of,many |
R13558 | T20442 | T20445 | det | these,molecules |
R13559 | T20443 | T20445 | amod | negative,molecules |
R13560 | T20444 | T20445 | amod | regulatory,molecules |
R13561 | T20445 | T20441 | pobj | molecules,of |
R13562 | T20446 | T20446 | ROOT | is,is |
R13563 | T20447 | T20448 | advmod | NF-κB,dependent |
R13564 | T20448 | T20446 | acomp | dependent,is |
R13565 | T20449 | T20446 | punct | ",",is |
R13566 | T20450 | T20446 | advcl | implicating,is |
R13567 | T20451 | T20450 | dobj | them,implicating |
R13568 | T20452 | T20450 | prep | in,implicating |
R13569 | T20453 | T20456 | det | the,regulation |
R13570 | T20454 | T20456 | amod | negative,regulation |
R13571 | T20455 | T20456 | compound | feedback,regulation |
R13572 | T20456 | T20452 | pobj | regulation,in |
R13573 | T20457 | T20456 | prep | of,regulation |
R13574 | T20458 | T20459 | amod | NF-κB,activation |
R13575 | T20459 | T20457 | pobj | activation,of |
R13576 | T20460 | T20446 | punct | .,is |
R13577 | T20461 | T20461 | ROOT | ABIN,ABIN |
R13578 | T20462 | T20464 | punct | ",",inhibitor |
R13579 | T20463 | T20464 | amod | A20-binding,inhibitor |
R13580 | T20464 | T20461 | appos | inhibitor,ABIN |
R13581 | T20465 | T20464 | prep | of,inhibitor |
R13582 | T20466 | T20465 | pobj | NF-κB,of |
R13583 | T20467 | T20461 | punct | ;,ABIN |
R13584 | T20468 | T20461 | conj | cIAP,ABIN |
R13585 | T20469 | T20468 | punct | ",",cIAP |
R13586 | T20470 | T20471 | amod | cellular,inhibitor |
R13587 | T20471 | T20468 | appos | inhibitor,cIAP |
R13588 | T20472 | T20471 | prep | of,inhibitor |
R13589 | T20473 | T20472 | pobj | apoptosis,of |
R13590 | T20474 | T20468 | punct | ;,cIAP |
R13591 | T20475 | T20468 | conj | CYLD,cIAP |
R13592 | T20476 | T20475 | punct | ",",CYLD |
R13593 | T20477 | T20475 | appos | cylindromatosis,CYLD |
R13594 | T20478 | T20475 | punct | ;,CYLD |
R13595 | T20479 | T20475 | conj | IKK,CYLD |
R13596 | T20480 | T20479 | punct | ",",IKK |
R13597 | T20481 | T20482 | compound | IκB,kinase |
R13598 | T20482 | T20479 | appos | kinase,IKK |
R13599 | T20483 | T20479 | punct | ;,IKK |
R13600 | T20484 | T20479 | conj | IκB,IKK |
R13601 | T20485 | T20484 | punct | ",",IκB |
R13602 | T20486 | T20484 | appos | inhibitor,IκB |
R13603 | T20487 | T20486 | prep | of,inhibitor |
R13604 | T20488 | T20487 | pobj | NF-κB,of |
R13605 | T20489 | T20484 | punct | ;,IκB |
R13606 | T20490 | T20484 | conj | IRAK,IκB |
R13607 | T20491 | T20490 | punct | ",",IRAK |
R13608 | T20492 | T20493 | amod | IL-1R-associated,kinase |
R13609 | T20493 | T20490 | appos | kinase,IRAK |
R13610 | T20494 | T20490 | punct | ;,IRAK |
R13611 | T20495 | T20490 | conj | MyD88,IRAK |
R13617 | T20501 | T20495 | appos | gene,MyD88 |
R13618 | T20502 | T20501 | nummod | 88,gene |
R13619 | T20503 | T20495 | punct | ;,MyD88 |
R13620 | T20504 | T20495 | conj | NEMO,MyD88 |
R13621 | T20505 | T20504 | punct | ",",NEMO |
R13622 | T20506 | T20508 | nmod | NF-κB,modulator |
R13623 | T20507 | T20508 | amod | essential,modulator |
R13624 | T20508 | T20504 | appos | modulator,NEMO |
R13625 | T20509 | T20504 | punct | ;,NEMO |
R13626 | T20510 | T20504 | conj | NF,NEMO |
R13627 | T20511 | T20510 | punct | ",",NF |
R13628 | T20512 | T20513 | amod | nuclear,factor |
R13629 | T20513 | T20510 | appos | factor,NF |
R13630 | T20514 | T20510 | punct | ;,NF |
R13631 | T20515 | T20510 | conj | RANK,NF |
R13632 | T20516 | T20515 | punct | ",",RANK |
R13633 | T20517 | T20518 | compound | receptor,activator |
R13634 | T20518 | T20515 | appos | activator,RANK |
R13635 | T20519 | T20518 | prep | of,activator |
R13636 | T20520 | T20519 | pobj | NF-κB,of |
R13637 | T20521 | T20461 | punct | ;,ABIN |
R13638 | T20522 | T20461 | conj | RIP1,ABIN |
R13639 | T20523 | T20522 | punct | ",",RIP1 |
R13640 | T20524 | T20526 | compound | receptor,protein |
R13641 | T20525 | T20526 | compound | interacting,protein |
R13642 | T20526 | T20461 | appos | protein,ABIN |
R13643 | T20527 | T20526 | nummod | 1,protein |
R13644 | T20528 | T20461 | punct | ;,ABIN |
R13645 | T20529 | T20461 | conj | SIGIRR,ABIN |
R13646 | T20530 | T20529 | punct | ",",SIGIRR |
R13647 | T20531 | T20532 | amod | single-immunoglobulinIL-1,receptor-related |
R13648 | T20532 | T20529 | amod | receptor-related,SIGIRR |
R13649 | T20533 | T20529 | punct | ;,SIGIRR |
R13650 | T20534 | T20529 | conj | TIR,SIGIRR |
R13651 | T20535 | T20534 | punct | ",",TIR |
R13652 | T20536 | T20537 | compound | Toll-like,receptor/IL |
R13653 | T20537 | T20534 | conj | receptor/IL,TIR |
R13654 | T20538 | T20539 | nummod | -1,R |
R13655 | T20539 | T20556 | ccomp | R,factor |
R13656 | T20540 | T20539 | punct | ;,R |
R13657 | T20541 | T20544 | npadvmod | TRAF,receptor-associated |
R13658 | T20542 | T20544 | punct | ",",receptor-associated |
R13659 | T20543 | T20544 | nsubj | TNF,receptor-associated |
R13660 | T20544 | T20556 | ccomp | receptor-associated,factor |
R13661 | T20545 | T20544 | dobj | factor,receptor-associated |
R13662 | T20546 | T20556 | punct | ;,factor |
R13663 | T20547 | T20556 | poss | TLR,factor |
R13664 | T20548 | T20550 | punct | ",",receptor |
R13665 | T20549 | T20550 | amod | Toll-like,receptor |
R13666 | T20550 | T20547 | appos | receptor,TLR |
R13667 | T20551 | T20547 | punct | ;,TLR |
R13668 | T20552 | T20547 | conj | TNF,TLR |
R13669 | T20553 | T20552 | punct | ",",TNF |
R13670 | T20554 | T20556 | compound | tumour,factor |
R13671 | T20555 | T20556 | compound | necrosis,factor |
R13672 | T20556 | T20556 | ROOT | factor,factor |
R13673 | T20557 | T20556 | punct | .,factor |
R14226 | T21854 | T21855 | compound | Noncanonical,NF-κB |
R14227 | T21855 | T21855 | ROOT | NF-κB,NF-κB |
R14228 | T21856 | T21855 | acl | signalling,NF-κB |
R14229 | T21857 | T21856 | punct | .,signalling |
R14230 | T21858 | T21858 | ROOT | CD40,CD40 |
R14231 | T21859 | T21858 | cc | and,CD40 |
R14232 | T21860 | T21862 | nsubj | RANK,activate |
R14233 | T21861 | T21862 | aux | can,activate |
R14234 | T21862 | T21858 | conj | activate,CD40 |
R14235 | T21863 | T21866 | det | the,pathway |
R14236 | T21864 | T21866 | amod | noncanonical,pathway |
R14237 | T21865 | T21866 | compound | NF-κB,pathway |
R14238 | T21866 | T21862 | dobj | pathway,activate |
R14239 | T21867 | T21868 | nsubj | that,is |
R14240 | T21868 | T21866 | relcl | is,pathway |
R14241 | T21869 | T21868 | acomp | dependent,is |
R14242 | T21870 | T21869 | prep | on,dependent |
R14243 | T21871 | T21872 | nsubj | NF-κB,inducing |
R14244 | T21872 | T21870 | pcomp | inducing,on |
R14245 | T21873 | T21878 | nmod | kinase,levels |
R14246 | T21874 | T21878 | punct | (,levels |
R14247 | T21875 | T21878 | compound | NIK,levels |
R14248 | T21876 | T21877 | punct | ),expression |
R14249 | T21877 | T21878 | compound | expression,levels |
R14250 | T21878 | T21872 | dobj | levels,inducing |
R14251 | T21879 | T21862 | punct | .,activate |
R14252 | T21880 | T21884 | prep | In,forms |
R14253 | T21881 | T21882 | amod | unstimulated,cells |
R14254 | T21882 | T21880 | pobj | cells,In |
R14255 | T21883 | T21884 | nsubj | NIK,forms |
R14256 | T21884 | T21884 | ROOT | forms,forms |
R14257 | T21885 | T21887 | det | a,complex |
R14258 | T21886 | T21887 | amod | cytosolic,complex |
R14259 | T21887 | T21884 | dobj | complex,forms |
R14260 | T21888 | T21887 | prep | with,complex |
R14261 | T21889 | T21890 | det | the,ubiquitin |
R14262 | T21890 | T21891 | nsubj | ubiquitin,ligases |
R14263 | T21891 | T21884 | conj | ligases,forms |
R14264 | T21892 | T21891 | dobj | TRAF2,ligases |
R14265 | T21893 | T21892 | punct | ",",TRAF2 |
R14266 | T21894 | T21892 | conj | TRAF3,TRAF2 |
R14267 | T21895 | T21894 | cc | and,TRAF3 |
R14268 | T21896 | T21894 | conj | cIAP1/2,TRAF3 |
R14269 | T21897 | T21896 | punct | ",",cIAP1/2 |
R14270 | T21898 | T21899 | nsubj | which,facilitates |
R14271 | T21899 | T21896 | relcl | facilitates,cIAP1/2 |
R14272 | T21900 | T21902 | det | the,polyubiquitination |
R14273 | T21901 | T21902 | amod | K48-linked,polyubiquitination |
R14274 | T21902 | T21899 | dobj | polyubiquitination,facilitates |
R14275 | T21903 | T21902 | cc | and,polyubiquitination |
R14276 | T21904 | T21905 | amod | proteasomal,degradation |
R14277 | T21905 | T21902 | conj | degradation,polyubiquitination |
R14278 | T21906 | T21905 | prep | of,degradation |
R14279 | T21907 | T21906 | pobj | NIK,of |
R14280 | T21908 | T21891 | punct | ",",ligases |
R14281 | T21909 | T21891 | advcl | keeping,ligases |
R14282 | T21910 | T21911 | compound | NIK,levels |
R14283 | T21911 | T21909 | dobj | levels,keeping |
R14284 | T21912 | T21909 | oprd | low,keeping |
R14285 | T21913 | T21891 | punct | .,ligases |
R14286 | T21914 | T21916 | mark | Upon,binding |
R14287 | T21915 | T21916 | advmod | ligand,binding |
R14288 | T21916 | T21920 | advcl | binding,recruited |
R14289 | T21917 | T21920 | punct | ",",recruited |
R14290 | T21918 | T21920 | nsubjpass | TRAF3,recruited |
R14291 | T21919 | T21920 | auxpass | is,recruited |
R14292 | T21920 | T21920 | ROOT | recruited,recruited |
R14293 | T21921 | T21920 | prep | to,recruited |
R14294 | T21922 | T21923 | det | the,receptor |
R14295 | T21923 | T21921 | pobj | receptor,to |
R14296 | T21924 | T21923 | punct | ",",receptor |
R14297 | T21925 | T21927 | advmod | where,directs |
R14298 | T21926 | T21927 | nummod | TRAF2,directs |
R14299 | T21927 | T21923 | relcl | directs,receptor |
R14300 | T21928 | T21930 | amod | nondegradative,polyubiquitination |
R14301 | T21929 | T21930 | amod | K63-linked,polyubiquitination |
R14302 | T21930 | T21927 | dobj | polyubiquitination,directs |
R14303 | T21931 | T21930 | prep | of,polyubiquitination |
R14304 | T21932 | T21931 | pobj | cIAP1/2,of |
R14305 | T21933 | T21927 | punct | ",",directs |
R14306 | T21934 | T21920 | advcl | resulting,recruited |
R14307 | T21935 | T21934 | prep | in,resulting |
R14308 | T21936 | T21937 | poss | their,activation |
R14309 | T21937 | T21935 | pobj | activation,in |
R14310 | T21938 | T21920 | punct | .,recruited |
R14311 | T21939 | T21941 | advmod | Subsequently,directs |
R14312 | T21940 | T21941 | nsubj | cIAP1/2,directs |
R14313 | T21941 | T21941 | ROOT | directs,directs |
R14314 | T21942 | T21944 | poss | its,polyubiquitination |
R14315 | T21943 | T21944 | amod | K48-linked,polyubiquitination |
R14316 | T21944 | T21941 | dobj | polyubiquitination,directs |
R14317 | T21945 | T21944 | prep | to,polyubiquitination |
R14318 | T21946 | T21945 | pobj | TRAF3,to |
R14319 | T21947 | T21944 | punct | ",",polyubiquitination |
R14320 | T21948 | T21949 | advmod | rather,than |
R14321 | T21949 | T21944 | cc | than,polyubiquitination |
R14322 | T21950 | T21949 | pobj | NIK,than |
R14323 | T21951 | T21941 | punct | .,directs |
R14324 | T21952 | T21957 | prep | As,is |
R14325 | T21953 | T21954 | det | a,result |
R14326 | T21954 | T21952 | pobj | result,As |
R14327 | T21955 | T21957 | punct | ",",is |
R14328 | T21956 | T21957 | nsubj | TRAF3,is |
R14329 | T21957 | T21957 | ROOT | is,is |
R14330 | T21958 | T21957 | acomp | degraded,is |
R14331 | T21959 | T21957 | cc | and,is |
R14332 | T21960 | T21961 | nsubj | NIK,is |
R14333 | T21961 | T21957 | conj | is,is |
R14334 | T21962 | T21961 | acomp | stabilised,is |
R14335 | T21963 | T21961 | punct | ",",is |
R14336 | T21964 | T21961 | advcl | resulting,is |
R14337 | T21965 | T21964 | prep | in,resulting |
R14338 | T21966 | T21968 | amod | increased,levels |
R14339 | T21967 | T21968 | compound | NIK,levels |
R14340 | T21968 | T21965 | pobj | levels,in |
R14341 | T21969 | T21968 | prep | in,levels |
R14342 | T21970 | T21971 | det | the,cell |
R14343 | T21971 | T21969 | pobj | cell,in |
R14344 | T21972 | T21961 | punct | .,is |
R14345 | T21973 | T21975 | nsubj | NIK,phosphorylates |
R14346 | T21974 | T21975 | advmod | then,phosphorylates |
R14347 | T21975 | T21975 | ROOT | phosphorylates,phosphorylates |
R14348 | T21976 | T21975 | cc | and,phosphorylates |
R14349 | T21977 | T21975 | conj | activates,phosphorylates |
R14350 | T21978 | T21977 | dobj | IKK1,activates |
R14351 | T21979 | T21978 | punct | ",",IKK1 |
R14352 | T21980 | T21981 | nsubj | which,mediates |
R14353 | T21981 | T21978 | relcl | mediates,IKK1 |
R14354 | T21982 | T21984 | nmod | NF-κB,phosphorylation |
R14355 | T21983 | T21984 | nummod | p100,phosphorylation |
R14356 | T21984 | T21981 | dobj | phosphorylation,mediates |
R14357 | T21985 | T21975 | punct | .,phosphorylates |
R14358 | T21986 | T21988 | nsubjpass | This,followed |
R14359 | T21987 | T21988 | auxpass | is,followed |
R14360 | T21988 | T21988 | ROOT | followed,followed |
R14361 | T21989 | T21988 | agent | by,followed |
R14362 | T21990 | T21991 | amod | K48-linked,polyubiquitination |
R14363 | T21991 | T21989 | pobj | polyubiquitination,by |
R14364 | T21992 | T21991 | cc | and,polyubiquitination |
R14365 | T21993 | T21995 | amod | partial,degradation |
R14366 | T21994 | T21995 | amod | proteasomal,degradation |
R14367 | T21995 | T21991 | conj | degradation,polyubiquitination |
R14368 | T21996 | T21995 | prep | of,degradation |
R14369 | T21997 | T21996 | pobj | p100,of |
R14370 | T21998 | T21995 | prep | to,degradation |
R14371 | T21999 | T21998 | pobj | p52,to |
R14372 | T22000 | T21999 | punct | ",",p52 |
R14373 | T22001 | T22002 | nsubj | which,forms |
R14374 | T22002 | T21999 | relcl | forms,p52 |
R14375 | T22003 | T22004 | det | a,heterodimer |
R14376 | T22004 | T22002 | dobj | heterodimer,forms |
R14377 | T22005 | T22004 | prep | with,heterodimer |
R14378 | T22006 | T22005 | pobj | RelB,with |
R14379 | T22007 | T22008 | aux | to,activate |
R14380 | T22008 | T22002 | advcl | activate,forms |
R14381 | T22009 | T22008 | dobj | transcription,activate |
R14382 | T22010 | T21988 | punct | .,followed |
R14383 | T22011 | T22019 | advmod | Next,identified |
R14384 | T22012 | T22011 | prep | to,Next |
R14385 | T22013 | T22012 | pobj | TRAF3,to |
R14386 | T22014 | T22019 | punct | ",",identified |
R14387 | T22015 | T22019 | nsubjpass | TRAF1,identified |
R14388 | T22016 | T22019 | aux | has,identified |
R14389 | T22017 | T22019 | advmod | also,identified |
R14390 | T22018 | T22019 | auxpass | been,identified |
R14391 | T22019 | T22019 | ROOT | identified,identified |
R14392 | T22020 | T22019 | prep | as,identified |
R14393 | T22021 | T22023 | det | a,regulator |
R14394 | T22022 | T22023 | amod | negative,regulator |
R14395 | T22023 | T22020 | pobj | regulator,as |
R14396 | T22024 | T22023 | prep | of,regulator |
R14397 | T22025 | T22026 | det | this,pathway |
R14398 | T22026 | T22024 | pobj | pathway,of |
R14399 | T22027 | T22023 | punct | ",",regulator |
R14400 | T22028 | T22029 | advmod | most,probably |
R14401 | T22029 | T22030 | advmod | probably,by |
R14402 | T22030 | T22019 | agent | by,identified |
R14403 | T22031 | T22030 | pcomp | competing,by |
R14404 | T22032 | T22031 | prep | with,competing |
R14405 | T22033 | T22036 | amod | other,factors |
R14406 | T22034 | T22036 | nmod | TNF,factors |
R14407 | T22035 | T22036 | amod | receptor-associated,factors |
R14408 | T22036 | T22032 | pobj | factors,with |
R14409 | T22037 | T22019 | punct | .,identified |
R14410 | T22038 | T22038 | ROOT | cIAP,cIAP |
R14411 | T22039 | T22038 | punct | ",",cIAP |
R14412 | T22040 | T22041 | amod | cellular,inhibitor |
R14413 | T22041 | T22038 | appos | inhibitor,cIAP |
R14414 | T22042 | T22041 | prep | of,inhibitor |
R14415 | T22043 | T22042 | pobj | apoptosis,of |
R14416 | T22044 | T22038 | punct | ;,cIAP |
R14417 | T22045 | T22038 | conj | IKK,cIAP |
R14418 | T22046 | T22045 | punct | ",",IKK |
R14419 | T22047 | T22048 | compound | IκB,kinase |
R14420 | T22048 | T22045 | appos | kinase,IKK |
R14421 | T22049 | T22045 | punct | ;,IKK |
R14422 | T22050 | T22045 | conj | NF,IKK |
R14423 | T22051 | T22050 | punct | ",",NF |
R14424 | T22052 | T22053 | amod | nuclear,factor |
R14425 | T22053 | T22050 | appos | factor,NF |
R14426 | T22054 | T22050 | punct | ;,NF |
R14427 | T22055 | T22050 | conj | RANK,NF |
R14428 | T22056 | T22055 | punct | ",",RANK |
R14429 | T22057 | T22058 | compound | receptor,activator |
R14430 | T22058 | T22038 | appos | activator,cIAP |
R14431 | T22059 | T22058 | prep | of,activator |
R14432 | T22060 | T22059 | pobj | NF-κB,of |
R14433 | T22061 | T22038 | punct | ;,cIAP |
R14434 | T22062 | T22038 | conj | TRAF,cIAP |
R14435 | T22063 | T22066 | punct | ",",factor |
R14436 | T22064 | T22066 | nmod | TNF,factor |
R14437 | T22065 | T22066 | amod | receptor-associated,factor |
R14438 | T22066 | T22038 | appos | factor,cIAP |
R14439 | T22067 | T22038 | punct | ;,cIAP |
R14440 | T22068 | T22038 | conj | TNF,cIAP |
R14441 | T22069 | T22068 | punct | ",",TNF |
R14442 | T22070 | T22072 | compound | tumour,factor |
R14443 | T22071 | T22072 | compound | necrosis,factor |
R14444 | T22072 | T22038 | appos | factor,cIAP |
R14445 | T22073 | T22038 | punct | .,cIAP |
R8765 | T13214 | T13215 | amod | A20-binding,inhibitors |
R10650 | T16042 | T16044 | amod | restricted,pattern |
R10651 | T16043 | T16044 | compound | expression,pattern |
R10652 | T16044 | T16039 | pobj | pattern,Because |
R10653 | T16045 | T16049 | punct | ",",be |
R10654 | T16046 | T16049 | nsubj | SIGIRR,be |
R10655 | T16047 | T16049 | aux | may,be |
R10656 | T16048 | T16049 | advmod | also,be |
R10657 | T16049 | T16049 | ROOT | be,be |
R10658 | T16050 | T16053 | det | an,target |
R10659 | T16051 | T16053 | amod | interesting,target |
R10660 | T16052 | T16053 | amod | therapeutic,target |
R10661 | T16053 | T16049 | attr | target,be |
R10662 | T16054 | T16049 | prep | in,be |
R10663 | T16055 | T16054 | pobj | RA,in |
R10664 | T16056 | T16049 | punct | .,be |
R9041 | T13490 | T13486 | pobj | proteins,of |
R11067 | T16789 | T16788 | prep | of,modulator |
R11068 | T16790 | T16791 | amod | NF-κB,signalling |
R11069 | T16791 | T16789 | pobj | signalling,of |
R11070 | T16792 | T16791 | prep | by,signalling |
R11071 | T16793 | T16796 | amod | certain,receptors |
R11072 | T16794 | T16796 | compound | TNF,receptors |
R11073 | T16795 | T16796 | compound | family,receptors |
R11074 | T16796 | T16792 | pobj | receptors,by |
R11075 | T16797 | T16796 | punct | ",",receptors |
R11076 | T16798 | T16799 | advmod | possibly,in |
R11077 | T16799 | T16788 | prep | in,modulator |
R11078 | T16800 | T16802 | det | a,manner |
R11079 | T16801 | T16802 | amod | cell-type-dependent,manner |
R11080 | T16802 | T16799 | pobj | manner,in |
R11081 | T16803 | T16805 | compound | [,] |
R11082 | T16804 | T16805 | compound | "71,72",] |
R11083 | T16805 | T16802 | appos | ],manner |
R11084 | T16806 | T16776 | punct | .,support |
R11085 | T16807 | T16810 | nsubj | Expression,is |
R11086 | T16808 | T16807 | prep | of,Expression |
R11087 | T16809 | T16808 | pobj | TRAF1,of |
R11088 | T16810 | T16810 | ROOT | is,is |
R11089 | T16811 | T16810 | acomp | inducible,is |
R11090 | T16812 | T16811 | prep | by,inducible |
R11091 | T16813 | T16812 | pobj | TNF,by |
R11121 | T16843 | T16844 | advmod | also,functions |
R11277 | T16999 | T16997 | pobj | [,with |
R11278 | T17000 | T17001 | nummod | 76,] |
R12126 | T18270 | T18269 | prep | in,overexpression |
R13298 | T20182 | T20181 | cc | and,signalling |
R13299 | T20183 | T20184 | amod | negative,regulators |
R13376 | T20260 | T20259 | prep | of,polyubiquitination |
R13377 | T20261 | T20260 | pobj | TRAFs,of |
R13378 | T20262 | T20261 | punct | ",",TRAFs |
R13379 | T20263 | T20261 | conj | RIP1,TRAFs |
R13612 | T20496 | T20495 | punct | ",",MyD88 |
R13613 | T20497 | T20498 | amod | myeloid,differentiation |
R13614 | T20498 | T20501 | nmod | differentiation,gene |
R13615 | T20499 | T20501 | amod | primary,gene |
R13616 | T20500 | T20501 | compound | response,gene |
R9950 | T14928 | T14929 | compound | adaptor,protein |
R9951 | T14929 | T14925 | pobj | protein,via |
R9952 | T14930 | T14921 | conj | p62,recruited |
R9953 | T14931 | T14933 | punct | (,known |
R9954 | T14932 | T14933 | advmod | also,known |
R10024 | T15002 | T15001 | dobj | CYLD,indicate |
R10025 | T15003 | T15001 | prep | as,indicate |
R10026 | T15004 | T15007 | det | a,factor |
R10027 | T15005 | T15007 | amod | potential,factor |
R10028 | T15006 | T15007 | amod | genetic,factor |
R4000 | T5957 | T5956 | pobj | IκBs,of |
R4002 | T5958 | T5973 | punct | (,p100 |
R4003 | T5959 | T5973 | nmod | IκBα,p100 |
R4005 | T5960 | T5959 | punct | ",",IκBα |
R4006 | T5961 | T5959 | conj | IκBβ,IκBα |
R4071 | T6054 | T6055 | amod | many,stimuli |
R4079 | T6055 | T6053 | pobj | stimuli,by |
R4084 | T6056 | T6055 | prep | including,stimuli |
DLUT931
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T22211 | 15004-15013 | Negative_regulation | denotes | inhibitor |
T22210 | 14891-14900 | Regulation | denotes | regulator |
T22209 | 14782-14793 | Binding | denotes | heterodimer |
T22208 | 14740-14751 | Protein_catabolism | denotes | degradation |
T22207 | 14649-14664 | Phosphorylation | denotes | phosphorylation |
T22206 | 14629-14637 | Positive_regulation | denotes | mediates |
T22205 | 14607-14616 | Positive_regulation | denotes | activates |
T22204 | 14545-14554 | Positive_regulation | denotes | increased |
T22203 | 14532-14541 | Positive_regulation | denotes | resulting |
T22202 | 14520-14530 | Positive_regulation | denotes | stabilised |
T22201 | 14500-14508 | Protein_catabolism | denotes | degraded |
T22200 | 14432-14450 | Binding | denotes | polyubiquitination |
T22199 | 14292-14299 | Negative_regulation | denotes | directs |
T22198 | 14326-14344 | Positive_regulation | denotes | polyubiquitination |
T22197 | 14300-14314 | Protein_catabolism | denotes | nondegradative |
T22196 | 14253-14262 | Binding | denotes | recruited |
T22195 | 14117-14128 | Positive_regulation | denotes | facilitates |
T22194 | 14218-14221 | Positive_regulation | denotes | low |
T22193 | 14179-14190 | Protein_catabolism | denotes | degradation |
T22192 | 14144-14162 | Binding | denotes | polyubiquitination |
T22191 | 13946-13955 | Regulation | denotes | dependent |
T22190 | 13987-13997 | Gene_expression | denotes | expression |
T22189 | 15143-15165 | Protein | denotes | tumour necrosis factor |
T22188 | 15138-15141 | Protein | denotes | TNF |
T22187 | 15071-15098 | Protein | denotes | receptor activator of NF-κB |
T22186 | 15065-15069 | Protein | denotes | RANK |
T22185 | 14846-14851 | Protein | denotes | TRAF1 |
T22184 | 14839-14844 | Protein | denotes | TRAF3 |
T22183 | 14799-14803 | Protein | denotes | RelB |
T22182 | 14763-14766 | Protein | denotes | p52 |
T22181 | 14755-14759 | Protein | denotes | p100 |
T22180 | 14644-14648 | Protein | denotes | p100 |
T22179 | 14617-14621 | Protein | denotes | IKK1 |
T22178 | 14579-14582 | Protein | denotes | NIK |
T22177 | 14555-14558 | Protein | denotes | NIK |
T22176 | 14513-14516 | Protein | denotes | NIK |
T22175 | 14491-14496 | Protein | denotes | TRAF3 |
T22174 | 14473-14476 | Protein | denotes | NIK |
T22173 | 14454-14459 | Protein | denotes | TRAF3 |
T22172 | 14407-14408 | Protein | denotes | 2 |
T22171 | 14401-14406 | Protein | denotes | cIAP1 |
T22170 | 14354-14355 | Protein | denotes | 2 |
T22169 | 14348-14353 | Protein | denotes | cIAP1 |
T22168 | 14286-14291 | Protein | denotes | TRAF2 |
T22167 | 14244-14249 | Protein | denotes | TRAF3 |
T22166 | 14108-14109 | Protein | denotes | 2 |
T22165 | 14102-14107 | Protein | denotes | cIAP1 |
T22164 | 14092-14097 | Protein | denotes | TRAF3 |
T22163 | 14085-14090 | Protein | denotes | TRAF2 |
T22162 | 14028-14031 | Protein | denotes | NIK |
T22161 | 14207-14210 | Protein | denotes | NIK |
T22160 | 14194-14197 | Protein | denotes | NIK |
T22159 | 13982-13985 | Protein | denotes | NIK |
T22158 | 13959-13980 | Protein | denotes | NF-κB inducing kinase |
T22157 | 13889-13893 | Protein | denotes | RANK |
T22156 | 13880-13884 | Protein | denotes | CD40 |
T20674 | 8787-8792 | Protein | denotes | MyD88 |
T20673 | 8779-8784 | Protein | denotes | TRADD |
T20672 | 8731-8777 | Protein | denotes | TNF receptor 1-associated death domain protein |
T20671 | 8672-8676 | Protein | denotes | TLR4 |
T20670 | 8662-8666 | Protein | denotes | RANK |
T20669 | 8656-8660 | Protein | denotes | CD40 |
T20668 | 8926-8931 | Protein | denotes | cIAP2 |
T20667 | 8919-8924 | Protein | denotes | cIAP1 |
T20666 | 8912-8917 | Protein | denotes | TRAF6 |
T20665 | 8905-8910 | Protein | denotes | TRAF2 |
T20664 | 8874-8879 | Protein | denotes | IRAK4 |
T20663 | 8867-8872 | Protein | denotes | IRAK1 |
T20662 | 8861-8865 | Protein | denotes | RIP1 |
T20661 | 8844-8848 | Protein | denotes | TRIF |
T20660 | 8649-8654 | Protein | denotes | TNFR1 |
T20726 | 10010-10017 | Binding | denotes | binding |
T20725 | 9988-9995 | Binding | denotes | compete |
T20724 | 9836-9846 | Negative_regulation | denotes | inhibiting |
T20723 | 9847-9857 | Gene_expression | denotes | expression |
T20722 | 9692-9701 | Binding | denotes | recruited |
T20721 | 9306-9317 | Binding | denotes | heterodimer |
T20720 | 9180-9194 | Phosphorylation | denotes | phosphorylates |
T20719 | 9150-9159 | Positive_regulation | denotes | activates |
T20718 | 9079-9089 | Positive_regulation | denotes | activation |
T20717 | 9063-9074 | Binding | denotes | recruitment |
T20716 | 8961-8979 | Ubiquitination | denotes | polyubiquitination |
T20715 | 10701-10723 | Protein | denotes | tumour necrosis factor |
T20714 | 10696-10699 | Protein | denotes | TNF |
T20713 | 10558-10600 | Protein | denotes | single-immunoglobulinIL-1 receptor-related |
T20712 | 10550-10556 | Protein | denotes | SIGIRR |
T20711 | 10518-10548 | Protein | denotes | receptor interacting protein 1 |
T20710 | 10512-10516 | Protein | denotes | RIP1 |
T20709 | 10483-10510 | Protein | denotes | receptor activator of NF-κB |
T20708 | 10477-10481 | Protein | denotes | RANK |
T20707 | 10430-10455 | Protein | denotes | NF-κB essential modulator |
T20706 | 10424-10428 | Protein | denotes | NEMO |
T20705 | 10374-10422 | Protein | denotes | myeloid differentiation primary response gene 88 |
T20704 | 10367-10372 | Protein | denotes | MyD88 |
T20703 | 10277-10292 | Protein | denotes | cylindromatosis |
T20702 | 10271-10275 | Protein | denotes | CYLD |
T20701 | 10200-10230 | Protein | denotes | A20-binding inhibitor of NF-κB |
T20700 | 10194-10198 | Protein | denotes | ABIN |
T20699 | 10031-10036 | Protein | denotes | TRAF6 |
T20698 | 10021-10026 | Protein | denotes | IRAK1 |
T20697 | 10001-10005 | Protein | denotes | TLR4 |
T20696 | 9953-9959 | Protein | denotes | SIGIRR |
T20695 | 9871-9876 | Protein | denotes | TRAF6 |
T20694 | 9861-9866 | Protein | denotes | IRAK1 |
T20693 | 9771-9774 | Protein | denotes | p62 |
T20692 | 9760-9766 | Protein | denotes | ABIN-1 |
T20691 | 9667-9672 | Protein | denotes | TRAF6 |
T20690 | 9658-9662 | Protein | denotes | RIP1 |
T20689 | 9542-9546 | Protein | denotes | CYLD |
T20688 | 9534-9537 | Protein | denotes | A20 |
T20687 | 9400-9405 | Protein | denotes | TRAF1 |
T20686 | 9329-9332 | Protein | denotes | p50 |
T20685 | 9321-9324 | Protein | denotes | p65 |
T20684 | 9195-9199 | Protein | denotes | IκBα |
T20683 | 9160-9164 | Protein | denotes | IKK2 |
T20682 | 9121-9125 | Protein | denotes | TAK1 |
T20681 | 9115-9119 | Protein | denotes | TAK1 |
T20680 | 9106-9110 | Protein | denotes | IKK2 |
T20679 | 9023-9027 | Protein | denotes | NEMO |
T20678 | 8999-9004 | Protein | denotes | IRAK1 |
T20677 | 8990-8994 | Protein | denotes | RIP1 |
T20676 | 8799-8842 | Protein | denotes | TIR domain-containing adaptor-inducing IFNβ |
T20675 | 8794-8797 | Protein | denotes | MAL |
T18593 | 32702-32712 | Gene_expression | denotes | expression |
T18592 | 32521-32530 | Positive_regulation | denotes | increased |
T18591 | 32510-32517 | Positive_regulation | denotes | leading |
T18590 | 32531-32540 | Localization | denotes | secretion |
T18589 | 32421-32430 | Negative_regulation | denotes | decreased |
T18588 | 32341-32350 | Regulation | denotes | regulator |
T18587 | 31672-31679 | Positive_regulation | denotes | promote |
T18586 | 31684-31694 | Gene_expression | denotes | production |
T18585 | 31458-31472 | Positive_regulation | denotes | overexpression |
T18584 | 31269-31278 | Gene_expression | denotes | producing |
T18583 | 31237-31250 | Gene_expression | denotes | overexpressed |
T18582 | 31067-31076 | Gene_expression | denotes | expressed |
T18581 | 30786-30801 | Regulation | denotes | NF-κB-dependent |
T18580 | 32659-32666 | Protein | denotes | miR-223 |
T18579 | 32646-32653 | Protein | denotes | miR-132 |
T18578 | 32638-32644 | Protein | denotes | miR-16 |
T18577 | 32575-32579 | Protein | denotes | IL-6 |
T18576 | 32544-32570 | Protein | denotes | matrix metalloproteinase-1 |
T18575 | 32500-32507 | Protein | denotes | miR-203 |
T18574 | 32368-32402 | Protein | denotes | monocyte chemoattractant protein 1 |
T18573 | 32324-32332 | Protein | denotes | miR-124a |
T18572 | 32152-32159 | Protein | denotes | miR-155 |
T18571 | 31754-31761 | Protein | denotes | miR-155 |
T18564 | 31220-31228 | Protein | denotes | miR-146a |
T18563 | 31055-31062 | Protein | denotes | miR-155 |
T18562 | 31015-31019 | Protein | denotes | RIP1 |
T18561 | 31006-31010 | Protein | denotes | IKKε |
T18560 | 30931-30938 | Protein | denotes | miR-155 |
T18559 | 30894-30902 | Protein | denotes | miR-146a |
T18558 | 30853-30858 | Protein | denotes | TRAF6 |
T18557 | 30843-30848 | Protein | denotes | IRAK1 |
T18556 | 30771-30779 | Protein | denotes | miR-146a |
T18555 | 30736-30739 | Protein | denotes | TNF |
T18554 | 30729-30734 | Protein | denotes | IL-1β |
T18553 | 30590-30597 | Protein | denotes | miR-155 |
T18552 | 30584-30585 | Protein | denotes | b |
T18551 | 30575-30583 | Protein | denotes | miR-146a |
T17070 | 30171-30182 | Binding | denotes | association |
T17069 | 29761-29769 | Binding | denotes | interact |
T17068 | 29720-29727 | Binding | denotes | recruit |
T17067 | 29639-29646 | Binding | denotes | binding |
T17066 | 29336-29345 | Negative_regulation | denotes | deficient |
T17065 | 29128-29137 | Negative_regulation | denotes | deficient |
T17064 | 29059-29073 | Positive_regulation | denotes | overexpression |
T17063 | 29038-29047 | Positive_regulation | denotes | inducible |
T17062 | 29015-29025 | Gene_expression | denotes | Expression |
T17061 | 30190-30195 | Protein | denotes | TRAF1 |
T17060 | 30057-30062 | Protein | denotes | TRAF1 |
T17059 | 29955-29960 | Protein | denotes | TRAF1 |
T17058 | 29728-29731 | Protein | denotes | A20 |
T17057 | 29708-29713 | Protein | denotes | TRAF1 |
T17056 | 29595-29600 | Protein | denotes | TRAF1 |
T17055 | 29528-29533 | Protein | denotes | TRAF1 |
T17054 | 29426-29431 | Protein | denotes | TRAF2 |
T17053 | 29330-29335 | Protein | denotes | TRAF1 |
T17052 | 29299-29303 | Protein | denotes | CD40 |
T17051 | 29251-29256 | Protein | denotes | TRAF1 |
T17050 | 29122-29127 | Protein | denotes | TRAF1 |
T17049 | 29170-29173 | Protein | denotes | TNF |
T17048 | 29092-29095 | Protein | denotes | TNF |
T17047 | 29077-29082 | Protein | denotes | TRAF1 |
T17046 | 29051-29054 | Protein | denotes | TNF |
T17045 | 29029-29034 | Protein | denotes | TRAF1 |
T17044 | 28862-28867 | Protein | denotes | TRAF1 |
T17043 | 28798-28807 | Protein | denotes | ubiquitin |
T17042 | 28688-28693 | Protein | denotes | TRAF1 |
T17041 | 28655-28687 | Protein | denotes | TNF receptor-associated factor 1 |
T16109 | 28574-28584 | Gene_expression | denotes | expression |
T16108 | 28520-28531 | Negative_regulation | denotes | compromised |
T16107 | 28391-28401 | Gene_expression | denotes | expression |
T16106 | 28219-28228 | Negative_regulation | denotes | deficient |
T16105 | 28026-28040 | Positive_regulation | denotes | overexpression |
T16104 | 27898-27907 | Gene_expression | denotes | expressed |
T16103 | 27872-27882 | Gene_expression | denotes | expression |
T16102 | 27616-27627 | Binding | denotes | interaction |
T16101 | 27553-27562 | Negative_regulation | denotes | inhibitor |
T16100 | 28594-28600 | Protein | denotes | SIGIRR |
T16099 | 28510-28516 | Protein | denotes | SIGIRR |
T16098 | 28405-28411 | Protein | denotes | SIGIRR |
T16097 | 28212-28218 | Protein | denotes | SIGIRR |
T16096 | 28168-28174 | Protein | denotes | SIGIRR |
T16095 | 28019-28025 | Protein | denotes | SIGIRR |
T16094 | 27843-27849 | Protein | denotes | SIGIRR |
T16093 | 27717-27722 | Protein | denotes | IL-1R |
T16092 | 27813-27819 | Protein | denotes | SIGIRR |
T16091 | 27666-27671 | Protein | denotes | TRAF6 |
T16090 | 27657-27662 | Protein | denotes | IRAK1 |
T16089 | 27650-27655 | Protein | denotes | MyD88 |
T16088 | 27566-27571 | Protein | denotes | IL-1R |
T16087 | 27464-27469 | Protein | denotes | TIR-8 |
T16086 | 27433-27439 | Protein | denotes | SIGIRR |
T16085 | 27388-27431 | Protein | denotes | Single-immunoglobulin IL-1 receptor-related |
T16084 | 27336-27379 | Protein | denotes | Single-immunoglobulin IL-1 receptor-related |
T15108 | 26635-26645 | Gene_expression | denotes | expression |
T15107 | 26406-26416 | Negative_regulation | denotes | deficiency |
T15106 | 25997-26006 | Gene_expression | denotes | expressed |
T15105 | 27244-27248 | Protein | denotes | CYLD |
T15104 | 27135-27139 | Protein | denotes | RANK |
T15103 | 27106-27110 | Protein | denotes | CYLD |
T15102 | 26993-26996 | Protein | denotes | p62 |
T15101 | 26896-26901 | Protein | denotes | TRAF6 |
T15100 | 26862-26866 | Protein | denotes | CYLD |
T15099 | 26824-26838 | Protein | denotes | sequestosome 1 |
T15098 | 26805-26808 | Protein | denotes | p62 |
T15097 | 26771-26780 | Protein | denotes | ubiquitin |
T15096 | 26757-26762 | Protein | denotes | TRAF6 |
T15095 | 26690-26695 | Protein | denotes | RANKL |
T15094 | 26630-26634 | Protein | denotes | CYLD |
T15093 | 26559-26564 | Protein | denotes | RANKL |
T15092 | 26420-26424 | Protein | denotes | CYLD |
T15091 | 26333-26337 | Protein | denotes | RANK |
T15090 | 26290-26294 | Protein | denotes | CYLD |
T15089 | 26143-26147 | Protein | denotes | CYLD |
T15088 | 25985-25988 | Protein | denotes | A20 |
T15087 | 25948-25952 | Protein | denotes | CYLD |
T15086 | 25933-25936 | Protein | denotes | A20 |
T15085 | 25884-25887 | Protein | denotes | A20 |
T15084 | 25813-25818 | Protein | denotes | TRAF2 |
T15083 | 25807-25811 | Protein | denotes | NEMO |
T15082 | 25674-25678 | Protein | denotes | RANK |
T15081 | 25588-25611 | Protein | denotes | deubiquitinating enzyme |
T15080 | 25578-25582 | Protein | denotes | CYLD |
T15079 | 25843-25847 | Protein | denotes | TAK1 |
T15078 | 25834-25838 | Protein | denotes | RIP1 |
T15077 | 25827-25832 | Protein | denotes | TRAF7 |
T15076 | 25820-25825 | Protein | denotes | TRAF6 |
T15075 | 25385-25389 | Protein | denotes | CYLD |
T15074 | 25279-25283 | Protein | denotes | CYLD |
T15073 | 25262-25277 | Protein | denotes | Cylindromatosis |
T15072 | 25238-25253 | Protein | denotes | Cylindromatosis |
T15114 | 26964-26974 | Gene_expression | denotes | expressing |
T15113 | 26876-26892 | Negative_regulation | denotes | deubiquitination |
T15112 | 26781-26788 | Binding | denotes | binding |
T15111 | 26743-26756 | Positive_regulation | denotes | ubiquitinated |
T15110 | 26730-26739 | Binding | denotes | recruited |
T15109 | 26658-26669 | Positive_regulation | denotes | upregulated |
T13722 | 24468-24474 | Regulation | denotes | depend |
T13721 | 24482-24492 | Gene_expression | denotes | expression |
T13720 | 23922-23931 | Negative_regulation | denotes | deficient |
T13719 | 23874-23882 | Negative_regulation | denotes | inhibits |
T13718 | 23790-23797 | Negative_regulation | denotes | lacking |
T13717 | 23810-23827 | Binding | denotes | ubiquitin-binding |
T13716 | 23752-23759 | Gene_expression | denotes | express |
T13715 | 23717-23726 | Gene_expression | denotes | expressed |
T13714 | 23523-23532 | Negative_regulation | denotes | deficient |
T13713 | 23502-23511 | Negative_regulation | denotes | deficient |
T13712 | 23335-23344 | Regulation | denotes | dependent |
T13711 | 23315-23325 | Gene_expression | denotes | expression |
T13710 | 23229-23235 | Binding | denotes | target |
T13709 | 23013-23024 | Binding | denotes | interacting |
T13708 | 22999-23008 | Gene_expression | denotes | expressed |
T13707 | 22878-22888 | Negative_regulation | denotes | inhibitors |
T13706 | 22870-22877 | Binding | denotes | binding |
T13705 | 24679-24685 | Protein | denotes | ABIN-1 |
T13704 | 24537-24540 | Protein | denotes | A20 |
T13703 | 24526-24532 | Protein | denotes | ABIN-3 |
T13702 | 24239-24242 | Protein | denotes | A20 |
T13701 | 24217-24223 | Protein | denotes | ABIN-1 |
T13700 | 24136-24142 | Protein | denotes | ABIN-1 |
T13699 | 24076-24079 | Protein | denotes | TNF |
T13698 | 24048-24054 | Protein | denotes | ABIN-1 |
T13697 | 23962-23965 | Protein | denotes | TNF |
T13696 | 23915-23921 | Protein | denotes | ABIN-1 |
T13695 | 23883-23886 | Protein | denotes | TNF |
T13694 | 23853-23859 | Protein | denotes | ABIN-1 |
T13693 | 23848-23851 | Protein | denotes | A20 |
T13692 | 23762-23789 | Protein | denotes | truncated and inactive form |
T13691 | 23707-23713 | Protein | denotes | ABIN-3 |
T13690 | 23516-23522 | Protein | denotes | ABIN-2 |
T13689 | 23495-23501 | Protein | denotes | ABIN-1 |
T13688 | 23383-23386 | Protein | denotes | A20 |
T13687 | 23308-23314 | Protein | denotes | ABIN-3 |
T13686 | 23297-23303 | Protein | denotes | ABIN-1 |
T13685 | 23292-23295 | Protein | denotes | A20 |
T13684 | 23236-23239 | Protein | denotes | A20 |
T13683 | 23080-23083 | Protein | denotes | TNF |
T13682 | 23009-23012 | Protein | denotes | A20 |
T13681 | 22959-22965 | Protein | denotes | TNIP-3 |
T13680 | 22947-22953 | Protein | denotes | TNIP-2 |
T13679 | 22939-22945 | Protein | denotes | TNIP-1 |
T13678 | 22917-22923 | Protein | denotes | ABIN-3 |
T13677 | 22906-22912 | Protein | denotes | ABIN-2 |
T13676 | 22898-22904 | Protein | denotes | ABIN-1 |
T13675 | 22866-22869 | Protein | denotes | A20 |
T11919 | 22545-22554 | Negative_regulation | denotes | repressed |
T11918 | 22559-22572 | Transcription | denotes | transcription |
T11917 | 22313-22319 | Regulation | denotes | affect |
T11916 | 21811-21820 | Negative_regulation | denotes | mutations |
T11915 | 21791-21802 | Binding | denotes | association |
T11914 | 21456-21460 | Negative_regulation | denotes | lack |
T11913 | 21166-21180 | Positive_regulation | denotes | overexpression |
T11912 | 21017-21027 | Gene_expression | denotes | transduced |
T11911 | 20970-20979 | Negative_regulation | denotes | decreased |
T11910 | 20586-20595 | Negative_regulation | denotes | decreased |
T11909 | 20503-20513 | Gene_expression | denotes | expression |
T11908 | 20275-20285 | Gene_expression | denotes | expressing |
T11907 | 20131-20140 | Regulation | denotes | regulated |
T11906 | 20110-20120 | Gene_expression | denotes | expression |
T11905 | 19933-19943 | Gene_expression | denotes | expression |
T11904 | 19790-19797 | Negative_regulation | denotes | lacking |
T11903 | 19475-19482 | Negative_regulation | denotes | lacking |
T11902 | 19315-19324 | Negative_regulation | denotes | deficient |
T11901 | 19130-19139 | Negative_regulation | denotes | deficient |
T11900 | 18985-18994 | Negative_regulation | denotes | inhibitor |
T11899 | 18774-18782 | Positive_regulation | denotes | requires |
T11898 | 18792-18809 | Binding | denotes | ubiquitin-binding |
T11897 | 18766-18773 | Regulation | denotes | targets |
T11896 | 18738-18749 | Binding | denotes | association |
T11895 | 22791-22794 | Protein | denotes | A20 |
T11894 | 22555-22558 | Protein | denotes | A20 |
T11893 | 22507-22510 | Protein | denotes | A20 |
T11892 | 22327-22330 | Protein | denotes | A20 |
T11891 | 22246-22249 | Protein | denotes | A20 |
T11890 | 22208-22216 | Protein | denotes | cytokine |
T11889 | 22176-22179 | Protein | denotes | TNF |
T11888 | 22151-22154 | Protein | denotes | TNF |
T11887 | 22116-22119 | Protein | denotes | A20 |
T11886 | 22029-22032 | Protein | denotes | A20 |
T11885 | 21982-21985 | Protein | denotes | A20 |
T11884 | 21828-21831 | Protein | denotes | A20 |
T11883 | 21607-21610 | Protein | denotes | A20 |
T11882 | 21461-21464 | Protein | denotes | A20 |
T11881 | 21257-21260 | Protein | denotes | A20 |
T11880 | 21162-21165 | Protein | denotes | A20 |
T11879 | 21013-21016 | Protein | denotes | A20 |
T11878 | 21004-21009 | Protein | denotes | IL-1β |
T11877 | 20996-20999 | Protein | denotes | TNF |
T11876 | 20869-20874 | Protein | denotes | IL-1β |
T11875 | 20861-20864 | Protein | denotes | TNF |
T11874 | 20703-20706 | Protein | denotes | A20 |
T11873 | 20639-20674 | Protein | denotes | monocyte chemo-attractant protein 1 |
T11872 | 20632-20637 | Protein | denotes | RANKL |
T11871 | 20618-20622 | Protein | denotes | IL-6 |
T11870 | 20611-20616 | Protein | denotes | IL-1β |
T11869 | 20606-20609 | Protein | denotes | TNF |
T11868 | 20499-20502 | Protein | denotes | A20 |
T11867 | 20271-20274 | Protein | denotes | A20 |
T11866 | 20168-20171 | Protein | denotes | A20 |
T11865 | 20106-20109 | Protein | denotes | A20 |
T11864 | 19929-19932 | Protein | denotes | A20 |
T11863 | 19798-19801 | Protein | denotes | A20 |
T11862 | 19677-19680 | Protein | denotes | A20 |
T11861 | 19643-19646 | Protein | denotes | TNF |
T11860 | 19483-19486 | Protein | denotes | A20 |
T11859 | 19360-19363 | Protein | denotes | TNF |
T11858 | 19311-19314 | Protein | denotes | A20 |
T11857 | 19126-19129 | Protein | denotes | A20 |
T11856 | 19062-19065 | Protein | denotes | A20 |
T11855 | 18964-18967 | Protein | denotes | A20 |
T11854 | 18882-18904 | Protein | denotes | Tax1-binding protein 1 |
T11853 | 18838-18877 | Protein | denotes | A20-binding inhibitor of NF-κB (ABIN) 1 |
T11852 | 18753-18756 | Protein | denotes | A20 |
T11851 | 18691-18694 | Protein | denotes | A20 |
T11850 | 18634-18635 | Protein | denotes | 2 |
T11849 | 18628-18633 | Protein | denotes | cIAP1 |
T11848 | 18618-18623 | Protein | denotes | TRAF2 |
T11847 | 18611-18616 | Protein | denotes | TRAF6 |
T11846 | 18577-18583 | Protein | denotes | Ubc5hc |
T11845 | 18567-18572 | Protein | denotes | Ubc13 |
T11844 | 18388-18392 | Protein | denotes | RIP2 |
T11843 | 18382-18386 | Protein | denotes | RIP1 |
T11842 | 18275-18278 | Protein | denotes | A20 |
T11841 | 18404-18409 | Protein | denotes | MALT1 |
T11840 | 18394-18399 | Protein | denotes | TRAF6 |
T11839 | 18132-18135 | Protein | denotes | TNF |
T11838 | 18038-18043 | Protein | denotes | NF-κB |
T11837 | 17986-18011 | Protein | denotes | ubiquitin-editing protein |
T11836 | 17972-17979 | Protein | denotes | TNFAIP3 |
T11835 | 17953-17956 | Protein | denotes | A20 |
T11834 | 17941-17944 | Protein | denotes | A20 |
T9170 | 17665-17679 | Phosphorylation | denotes | phosphorylates |
T9169 | 17580-17595 | Phosphorylation | denotes | phosphorylating |
T9168 | 17428-17436 | Positive_regulation | denotes | enhanced |
T9167 | 17418-17424 | Positive_regulation | denotes | result |
T9166 | 17462-17473 | Protein_catabolism | denotes | degradation |
T9165 | 17442-17452 | Positive_regulation | denotes | activation |
T9164 | 17344-17352 | Positive_regulation | denotes | inactive |
T9163 | 17333-17343 | Gene_expression | denotes | expressing |
T9162 | 17302-17311 | Negative_regulation | denotes | deficient |
T9161 | 17781-17785 | Protein | denotes | IKK1 |
T9160 | 17680-17683 | Protein | denotes | NIK |
T9159 | 17660-17664 | Protein | denotes | IKK1 |
T9158 | 17480-17484 | Protein | denotes | IKK1 |
T9157 | 17596-17601 | Protein | denotes | STAT1 |
T9156 | 17457-17461 | Protein | denotes | IκBα |
T9155 | 17437-17441 | Protein | denotes | IKK2 |
T9154 | 17353-17357 | Protein | denotes | IKK1 |
T9153 | 17297-17301 | Protein | denotes | IKK1 |
T9152 | 17069-17073 | Protein | denotes | IKK1 |
T9151 | 16915-16921 | Protein | denotes | TOLLIP |
T9150 | 16903-16909 | Protein | denotes | IRAK-M |
T9149 | 16895-16901 | Protein | denotes | MyD88s |
T7225 | 13781-13793 | Localization | denotes | accumulation |
T7224 | 13751-13762 | Protein_catabolism | denotes | degradation |
T7223 | 13715-13724 | Localization | denotes | releasing |
T7222 | 13647-13656 | Positive_regulation | denotes | essential |
T7221 | 13678-13689 | Protein_catabolism | denotes | degradation |
T7220 | 13610-13617 | Binding | denotes | attract |
T7219 | 13533-13539 | Negative_regulation | denotes | remove |
T7218 | 13431-13438 | Positive_regulation | denotes | leading |
T7217 | 13457-13468 | Protein_catabolism | denotes | degradation |
T7216 | 13206-13215 | Regulation | denotes | regulated |
T7215 | 13122-13131 | Positive_regulation | denotes | activated |
T7214 | 12832-12841 | Binding | denotes | processed |
T7213 | 12615-12639 | Regulation | denotes | ubiquitination-dependent |
T7212 | 12588-12596 | Positive_regulation | denotes | activate |
T7211 | 12556-12567 | Binding | denotes | interaction |
T7210 | 12509-12517 | Binding | denotes | recruits |
T7209 | 12434-12441 | Positive_regulation | denotes | leading |
T7208 | 12445-12460 | Binding | denotes | oligomerisation |
T7207 | 12361-12369 | Binding | denotes | recruits |
T7206 | 12033-12040 | Positive_regulation | denotes | induces |
T7205 | 12212-12219 | Binding | denotes | recruit |
T7204 | 12045-12056 | Binding | denotes | recruitment |
T7203 | 11893-11901 | Positive_regulation | denotes | activate |
T7202 | 11488-11505 | Binding | denotes | ubiquitin-binding |
T7201 | 11447-11454 | Binding | denotes | recruit |
T7200 | 11313-11327 | Binding | denotes | ubiquitination |
T7199 | 11219-11227 | Positive_regulation | denotes | modified |
T7198 | 11171-11182 | Positive_regulation | denotes | stimulation |
T7197 | 11071-11075 | Binding | denotes | bind |
T7196 | 10826-10837 | Binding | denotes | recruitment |
T7195 | 8484-8492 | Positive_regulation | denotes | required |
T7194 | 15890-15894 | Protein | denotes | CD40 |
T7193 | 15850-15855 | Protein | denotes | TRAF3 |
T7192 | 15803-15808 | Protein | denotes | TRAF2 |
T7191 | 15780-15784 | Protein | denotes | IL-6 |
T7190 | 15747-15751 | Protein | denotes | CD40 |
T7189 | 15725-15730 | Protein | denotes | TRAF6 |
T7188 | 15676-15680 | Protein | denotes | CD40 |
T7187 | 15499-15504 | Protein | denotes | TRAF3 |
T7186 | 15489-15494 | Protein | denotes | TRAF2 |
T7185 | 15440-15445 | Protein | denotes | TRAF6 |
T7184 | 15429-15434 | Protein | denotes | TRAF5 |
T7183 | 15422-15427 | Protein | denotes | TRAF3 |
T7182 | 15415-15420 | Protein | denotes | TRAF2 |
T7181 | 15408-15413 | Protein | denotes | TRAF1 |
T7180 | 15357-15361 | Protein | denotes | RANK |
T7179 | 15348-15352 | Protein | denotes | CD40 |
T7178 | 15228-15232 | Protein | denotes | RANK |
T7177 | 15201-15223 | Protein | denotes | lymphotoxin β receptor |
T7176 | 15195-15199 | Protein | denotes | CD40 |
T7175 | 13798-13802 | Protein | denotes | IKK1 |
T7174 | 13777-13780 | Protein | denotes | NIK |
T7173 | 13725-13728 | Protein | denotes | NIK |
T7172 | 13672-13677 | Protein | denotes | TRAF3 |
T7171 | 13634-13635 | Protein | denotes | 2 |
T7170 | 13628-13633 | Protein | denotes | cIAP1 |
T7169 | 13618-13623 | Protein | denotes | TRAF2 |
T7168 | 13540-13545 | Protein | denotes | TRAF3 |
T7167 | 13395-13396 | Protein | denotes | 2 |
T7166 | 13389-13394 | Protein | denotes | cIAP1 |
T7165 | 13378-13383 | Protein | denotes | TRAF3 |
T7164 | 13371-13376 | Protein | denotes | TRAF2 |
T7163 | 13330-13333 | Protein | denotes | NIK |
T7162 | 13426-13429 | Protein | denotes | NIK |
T7161 | 13185-13188 | Protein | denotes | NIK |
T7160 | 13179-13182 | Protein | denotes | NIK |
T7159 | 13156-13177 | Protein | denotes | NF-κB inducing kinase |
T7158 | 13107-13111 | Protein | denotes | IKK1 |
T7157 | 12892-12896 | Protein | denotes | RelB |
T7156 | 12863-12866 | Protein | denotes | p52 |
T7155 | 12824-12828 | Protein | denotes | p100 |
T7154 | 12790-12794 | Protein | denotes | RANK |
T7153 | 12780-12784 | Protein | denotes | CD40 |
T7152 | 12765-12778 | Protein | denotes | BAFF receptor |
T7151 | 12741-12763 | Protein | denotes | lymphotoxin β receptor |
T7150 | 12662-12665 | Protein | denotes | TNF |
T7149 | 12597-12601 | Protein | denotes | TAK1 |
T7148 | 12533-12537 | Protein | denotes | RIP1 |
T7147 | 12518-12523 | Protein | denotes | TRAF6 |
T7146 | 12499-12503 | Protein | denotes | TRIF |
T7145 | 12487-12492 | Protein | denotes | TRAF6 |
T7144 | 12427-12432 | Protein | denotes | TRAF6 |
T7143 | 12347-12352 | Protein | denotes | MyD88 |
T7142 | 12326-12330 | Protein | denotes | TRIF |
T7141 | 12281-12324 | Protein | denotes | TIR domain-containing adaptor-inducing IFNβ |
T7140 | 12270-12275 | Protein | denotes | MyD88 |
T7139 | 12220-12268 | Protein | denotes | myeloid differentiation primary response gene 88 |
T7138 | 12156-12160 | Protein | denotes | TRAM |
T7137 | 12125-12154 | Protein | denotes | TRIF-related adaptor molecule |
T7136 | 12116-12118 | Protein | denotes | Ma |
T7135 | 12060-12094 | Protein | denotes | Toll/IL-1 receptor adaptor protein |
T7134 | 11994-11998 | Protein | denotes | TLR4 |
T7133 | 11906-11910 | Protein | denotes | TAK1 |
T7132 | 11680-11683 | Protein | denotes | TNF |
T7131 | 11621-11625 | Protein | denotes | NEMO |
T7130 | 11529-11530 | Protein | denotes | 2 |
T7129 | 11524-11528 | Protein | denotes | TAB1 |
T7128 | 11515-11519 | Protein | denotes | NEMO |
T7127 | 11467-11471 | Protein | denotes | TAK1 |
T7126 | 11405-11409 | Protein | denotes | RIP1 |
T7125 | 11308-11312 | Protein | denotes | RIP1 |
T7124 | 11282-11283 | Protein | denotes | 2 |
T7123 | 11276-11281 | Protein | denotes | cIAP1 |
T7122 | 11270-11271 | Protein | denotes | 5 |
T7121 | 11264-11269 | Protein | denotes | TRAF2 |
T7120 | 11203-11207 | Protein | denotes | RIP1 |
T7119 | 11167-11170 | Protein | denotes | TNF |
T7118 | 11146-11151 | Protein | denotes | cIAP2 |
T7117 | 11101-11141 | Protein | denotes | cellular inhibitor of apoptosis (cIAP) 1 |
T7116 | 11050-11055 | Protein | denotes | TRAF5 |
T7115 | 11006-11045 | Protein | denotes | TNF receptor-associated factor (TRAF) 2 |
T7114 | 10935-10939 | Protein | denotes | RIP1 |
T7113 | 10903-10933 | Protein | denotes | receptor interacting protein 1 |
T7112 | 10881-10886 | Protein | denotes | TRADD |
T7111 | 10841-10879 | Protein | denotes | TNF receptor-1-associated death domain |
T7110 | 10795-10798 | Protein | denotes | TNF |
T7109 | 10782-10785 | Protein | denotes | TNF |
T7108 | 8474-8478 | Protein | denotes | IKK1 |
T7107 | 8460-8464 | Protein | denotes | NEMO |
T7106 | 8451-8455 | Protein | denotes | IKK2 |
T7105 | 8394-8398 | Protein | denotes | IKKγ |
T7104 | 8373-8377 | Protein | denotes | NEMO |
T7103 | 8346-8371 | Protein | denotes | NF-κB essential modulator |
T7102 | 8313-8317 | Protein | denotes | IKKβ |
T7101 | 8304-8308 | Protein | denotes | IKKα |
T7100 | 8284-8288 | Protein | denotes | IKK2 |
T7099 | 8275-8279 | Protein | denotes | IKK1 |
T7098 | 7830-7835 | Protein | denotes | RANKL |
T7097 | 7808-7811 | Protein | denotes | TNF |
T7096 | 7481-7484 | Protein | denotes | p50 |
T7095 | 7473-7476 | Protein | denotes | p52 |
T7094 | 7446-7450 | Protein | denotes | p105 |
T7093 | 7437-7441 | Protein | denotes | p100 |
T7092 | 7374-7379 | Protein | denotes | Bcl-3 |
T7091 | 7365-7369 | Protein | denotes | IκBξ |
T7090 | 7326-7332 | Protein | denotes | NF-κB2 |
T7089 | 7306-7310 | Protein | denotes | p100 |
T7088 | 7297-7303 | Protein | denotes | NF-κB1 |
T7087 | 7277-7281 | Protein | denotes | p105 |
T7086 | 7271-7275 | Protein | denotes | IκBε |
T7085 | 7265-7269 | Protein | denotes | IκBβ |
T7084 | 7259-7263 | Protein | denotes | IκBα |
T7233 | 15752-15760 | Positive_regulation | denotes | mediated |
T7232 | 15734-15742 | Positive_regulation | denotes | required |
T7231 | 15785-15795 | Gene_expression | denotes | production |
T7230 | 15681-15689 | Positive_regulation | denotes | mediated |
T7229 | 15323-15330 | Binding | denotes | binding |
T7228 | 13764-13773 | Positive_regulation | denotes | resulting |
T7227 | 13700-13711 | Positive_regulation | denotes | contributes |
T7226 | 13803-13818 | Phosphorylation | denotes | phosphorylation |
T3400 | 6570-6577 | Positive_regulation | denotes | induced |
T3399 | 6147-6156 | Positive_regulation | denotes | increased |
T3398 | 6032-6040 | Localization | denotes | released |
T3397 | 5995-6003 | Localization | denotes | secreted |
T3396 | 4756-4764 | Positive_regulation | denotes | Enhanced |
T3395 | 4765-4775 | Gene_expression | denotes | expression |
T3394 | 4264-4273 | Gene_expression | denotes | expressed |
T3393 | 4207-4214 | Binding | denotes | Binding |
T3392 | 4146-4157 | Positive_regulation | denotes | upregulated |
T3391 | 3967-3976 | Gene_expression | denotes | expressed |
T3390 | 3650-3660 | Positive_regulation | denotes | activation |
T3389 | 6759-6769 | Protein | denotes | tenascin C |
T3388 | 6749-6757 | Protein | denotes | biglycan |
T3387 | 6736-6747 | Protein | denotes | fibronectin |
T3386 | 6565-6569 | Protein | denotes | TLR4 |
T3385 | 6341-6367 | Protein | denotes | myeloid-related protein 14 |
T3384 | 6311-6336 | Protein | denotes | Myeloid-related protein 8 |
T3383 | 6248-6253 | Protein | denotes | HMGB1 |
T3382 | 6183-6188 | Protein | denotes | HMGB1 |
T3381 | 6138-6143 | Protein | denotes | HMGB1 |
T3380 | 6099-6111 | Protein | denotes | TLR4 ligands |
T3379 | 5954-5973 | Protein | denotes | chromatin component |
T3378 | 5927-5932 | Protein | denotes | HMGB1 |
T3377 | 5880-5925 | Protein | denotes | High mobility group box chromosomal protein 1 |
T3376 | 5011-5033 | Protein | denotes | lymphotoxin β receptor |
T3375 | 4957-4961 | Protein | denotes | BAFF |
T3374 | 4836-4840 | Protein | denotes | BAFF |
T3373 | 4810-4834 | Protein | denotes | B-cell activating factor |
T3372 | 4576-4580 | Protein | denotes | CD40 |
T3371 | 4302-4305 | Protein | denotes | CD4 |
T3370 | 4235-4240 | Protein | denotes | CD154 |
T3369 | 4222-4233 | Protein | denotes | CD40 ligand |
T3368 | 4197-4200 | Protein | denotes | TNF |
T3367 | 3919-3945 | Protein | denotes | TNF receptor family member |
T3366 | 3903-3907 | Protein | denotes | CD40 |
T3365 | 3789-3793 | Protein | denotes | RANK |
T3364 | 3693-3697 | Protein | denotes | RANK |
T3363 | 3664-3691 | Protein | denotes | receptor activator of NF-κB |
T3362 | 3450-3453 | Protein | denotes | TNF |
T3361 | 3375-3378 | Protein | denotes | TNF |
T3360 | 3316-3319 | Protein | denotes | TNF |
T1404 | 2629-2638 | Positive_regulation | denotes | mediating |
T1403 | 2643-2650 | Regulation | denotes | effects |
T1402 | 1823-1831 | Regulation | denotes | regulate |
T1401 | 1836-1846 | Gene_expression | denotes | expression |
T1400 | 2966-2971 | Protein | denotes | c-REL |
T1399 | 2953-2960 | Protein | denotes | TNFAIP3 |
T1398 | 2946-2951 | Protein | denotes | TRAF1 |
T1397 | 2940-2944 | Protein | denotes | CD40 |
T1396 | 2690-2695 | Protein | denotes | RANKL |
T1395 | 2654-2688 | Protein | denotes | receptor activator of NF-κB ligand |
T1394 | 2035-2038 | Protein | denotes | TNF |
T1393 | 1884-1887 | Protein | denotes | TNF |
T1392 | 1758-1763 | Protein | denotes | c-Rel |
T1391 | 1752-1756 | Protein | denotes | RelB |
T1390 | 1746-1750 | Protein | denotes | RelA |
T1389 | 1739-1742 | Protein | denotes | p65 |
T1388 | 1731-1737 | Protein | denotes | NF-κB1 |
T1387 | 1723-1727 | Protein | denotes | p105 |
T1386 | 1715-1721 | Protein | denotes | NF-κB2 |
T1385 | 1932-1963 | Protein | denotes | inducible nitric oxide synthase |
T1384 | 1901-1918 | Protein | denotes | cyclo-oxygenase-2 |
T1383 | 1895-1899 | Protein | denotes | IL-6 |
T1382 | 1707-1711 | Protein | denotes | p100 |
T18570 | 31680-31683 | Protein | denotes | TNF |
T18569 | 31651-31658 | Protein | denotes | miR-155 |
T18568 | 31450-31457 | Protein | denotes | miR-155 |
T18567 | 31364-31372 | Protein | denotes | miR-146a |
T18566 | 31263-31268 | Protein | denotes | IL-17 |
T18565 | 31254-31257 | Protein | denotes | CD4 |
R9179 | T13678 | T13709 | themeOf | ABIN-3,interacting |
R9182 | T13682 | T13709 | themeOf | A20,interacting |
R9185 | T13685 | T13712 | causeOf | A20,dependent |
R9187 | T13686 | T13712 | causeOf | ABIN-1,dependent |
R9188 | T13686 | T13712 | causeOf | ABIN-1,dependent |
R9189 | T13687 | T13711 | themeOf | ABIN-3,expression |
R9195 | T13692 | T13717 | themeOf | truncated and inactive form,ubiquitin-binding |
R9196 | T13693 | T13719 | themeOf | A20,inhibits |
R9197 | T13694 | T13719 | causeOf | ABIN-1,inhibits |
R9198 | T13696 | T13720 | themeOf | ABIN-1,deficient |
R9199 | T13703 | T13721 | themeOf | ABIN-3,expression |
R9203 | T13711 | T13712 | themeOf | expression,dependent |
R2685 | T3367 | T3392 | themeOf | TNF receptor family member,upregulated |
R2686 | T3367 | T3391 | themeOf | TNF receptor family member,expressed |
R2687 | T3369 | T3393 | themeOf | CD40 ligand,Binding |
R2688 | T3370 | T3393 | themeOf | CD154,Binding |
R2689 | T3370 | T3394 | themeOf | CD154,expressed |
R2691 | T3373 | T3395 | themeOf | B-cell activating factor,expression |
R2692 | T3374 | T3395 | themeOf | BAFF,expression |
R2695 | T3379 | T3397 | themeOf | chromatin component,secreted |
R2696 | T3379 | T3398 | themeOf | chromatin component,released |
R2697 | T3381 | T3399 | themeOf | HMGB1,increased |
R2700 | T3386 | T3400 | themeOf | TLR4,induced |
R2705 | T3395 | T3396 | themeOf | expression,Enhanced |
R2706 | T3395 | T3396 | themeOf | expression,Enhanced |
R4973 | T7106 | T7195 | themeOf | IKK2,required |
R4974 | T7107 | T7195 | themeOf | NEMO,required |
R4975 | T7108 | T7195 | causeOf | IKK1,required |
R4976 | T7108 | T7195 | causeOf | IKK1,required |
R4978 | T7111 | T7196 | themeOf | TNF receptor-1-associated death domain,recruitment |
R4979 | T7112 | T7196 | themeOf | TRADD,recruitment |
R4980 | T7112 | T7196 | themeOf | TRADD,recruitment |
R4981 | T7113 | T7196 | themeOf | receptor interacting protein 1,recruitment |
R4982 | T7113 | T7197 | themeOf | receptor interacting protein 1,bind |
R4983 | T7113 | T7196 | themeOf | receptor interacting protein 1,recruitment |
R4984 | T7113 | T7197 | themeOf | receptor interacting protein 1,bind |
R4985 | T7113 | T7197 | themeOf | receptor interacting protein 1,bind |
R4987 | T7114 | T7196 | themeOf | RIP1,recruitment |
R4988 | T7114 | T7197 | themeOf | RIP1,bind |
R4989 | T7114 | T7197 | themeOf | RIP1,bind |
R4990 | T7114 | T7197 | themeOf | RIP1,bind |
R4991 | T7115 | T7197 | themeOf | TNF receptor-associated factor (TRAF) 2,bind |
R4992 | T7115 | T7197 | themeOf | TNF receptor-associated factor (TRAF) 2,bind |
R4993 | T7116 | T7197 | themeOf | TRAF5,bind |
R4994 | T7116 | T7197 | themeOf | TRAF5,bind |
R4995 | T7116 | T7197 | themeOf | TRAF5,bind |
R4996 | T7116 | T7197 | themeOf | TRAF5,bind |
R4997 | T7117 | T7197 | themeOf | cellular inhibitor of apoptosis (cIAP) 1,bind |
R4998 | T7117 | T7197 | themeOf | cellular inhibitor of apoptosis (cIAP) 1,bind |
R4999 | T7117 | T7197 | themeOf | cellular inhibitor of apoptosis (cIAP) 1,bind |
R5000 | T7117 | T7197 | themeOf | cellular inhibitor of apoptosis (cIAP) 1,bind |
R5001 | T7118 | T7197 | themeOf | cIAP2,bind |
R5002 | T7118 | T7197 | themeOf | cIAP2,bind |
R5003 | T7118 | T7197 | themeOf | cIAP2,bind |
R5004 | T7118 | T7197 | themeOf | cIAP2,bind |
R5005 | T7119 | T7198 | themeOf | TNF,stimulation |
R5006 | T7120 | T7199 | themeOf | RIP1,modified |
R5007 | T7121 | T7200 | themeOf | TRAF2,ubiquitination |
R5009 | T7123 | T7200 | themeOf | cIAP1,ubiquitination |
R5010 | T7125 | T7200 | themeOf | RIP1,ubiquitination |
R5011 | T7125 | T7200 | themeOf | RIP1,ubiquitination |
R5012 | T7127 | T7201 | themeOf | TAK1,recruit |
R5013 | T7127 | T7201 | themeOf | TAK1,recruit |
R5014 | T7127 | T7201 | themeOf | TAK1,recruit |
R5015 | T7128 | T7201 | themeOf | NEMO,recruit |
R5016 | T7128 | T7202 | themeOf | NEMO,ubiquitin-binding |
R5017 | T7128 | T7202 | themeOf | NEMO,ubiquitin-binding |
R5018 | T7129 | T7202 | themeOf | TAB1,ubiquitin-binding |
R5019 | T7129 | T7201 | themeOf | TAB1,recruit |
R5020 | T7129 | T7202 | themeOf | TAB1,ubiquitin-binding |
R5021 | T7130 | T7201 | themeOf | 2,recruit |
R5022 | T7130 | T7202 | themeOf | 2,ubiquitin-binding |
R5023 | T7130 | T7202 | themeOf | 2,ubiquitin-binding |
R5024 | T7133 | T7203 | themeOf | TAK1,activate |
R5025 | T7135 | T7204 | themeOf | Toll/IL-1 receptor adaptor protein,recruitment |
R5026 | T7135 | T7205 | themeOf | Toll/IL-1 receptor adaptor protein,recruit |
R5027 | T7135 | T7204 | themeOf | Toll/IL-1 receptor adaptor protein,recruitment |
R5028 | T7135 | T7205 | themeOf | Toll/IL-1 receptor adaptor protein,recruit |
R5029 | T7135 | T7205 | themeOf | Toll/IL-1 receptor adaptor protein,recruit |
R5030 | T7135 | T7205 | themeOf | Toll/IL-1 receptor adaptor protein,recruit |
R5032 | T7137 | T7204 | themeOf | TRIF-related adaptor molecule,recruitment |
R5033 | T7137 | T7204 | themeOf | TRIF-related adaptor molecule,recruitment |
R5034 | T7137 | T7205 | themeOf | TRIF-related adaptor molecule,recruit |
R5035 | T7137 | T7205 | themeOf | TRIF-related adaptor molecule,recruit |
R5036 | T7138 | T7204 | themeOf | TRAM,recruitment |
R5037 | T7138 | T7204 | themeOf | TRAM,recruitment |
R5040 | T7138 | T7205 | themeOf | TRAM,recruit |
R5041 | T7138 | T7205 | themeOf | TRAM,recruit |
R5042 | T7139 | T7205 | themeOf | myeloid differentiation primary response gene 88,recruit |
R5043 | T7140 | T7205 | themeOf | MyD88,recruit |
R5044 | T7141 | T7205 | themeOf | TIR domain-containing adaptor-inducing IFNβ,recruit |
R5045 | T7141 | T7205 | themeOf | TIR domain-containing adaptor-inducing IFNβ,recruit |
R5046 | T7141 | T7205 | themeOf | TIR domain-containing adaptor-inducing IFNβ,recruit |
R5047 | T7142 | T7205 | themeOf | TRIF,recruit |
R5048 | T7142 | T7205 | themeOf | TRIF,recruit |
R5049 | T7142 | T7205 | themeOf | TRIF,recruit |
R5053 | T7143 | T7207 | themeOf | MyD88,recruits |
R5054 | T7144 | T7207 | themeOf | TRAF6,recruits |
R5055 | T7145 | T7208 | themeOf | TRAF6,oligomerisation |
R5056 | T7146 | T7210 | themeOf | TRIF,recruits |
R5057 | T7146 | T7211 | themeOf | TRIF,interaction |
R5058 | T7146 | T7210 | themeOf | TRIF,recruits |
R5059 | T7146 | T7211 | themeOf | TRIF,interaction |
R5060 | T7147 | T7210 | themeOf | TRAF6,recruits |
R5061 | T7147 | T7211 | themeOf | TRAF6,interaction |
R5062 | T7147 | T7211 | themeOf | TRAF6,interaction |
R5063 | T7148 | T7210 | themeOf | RIP1,recruits |
R5064 | T7148 | T7211 | themeOf | RIP1,interaction |
R5065 | T7148 | T7211 | themeOf | RIP1,interaction |
R5066 | T7149 | T7212 | themeOf | TAK1,activate |
R5068 | T7155 | T7214 | themeOf | p100,processed |
R5069 | T7156 | T7214 | themeOf | p52,processed |
R5070 | T7158 | T7215 | themeOf | IKK1,activated |
R5071 | T7159 | T7215 | causeOf | NF-κB inducing kinase,activated |
R5073 | T7161 | T7216 | themeOf | NIK,regulated |
R5074 | T7163 | T7217 | themeOf | NIK,degradation |
R5077 | T7167 | T7217 | themeOf | 2,degradation |
R5078 | T7168 | T7219 | themeOf | TRAF3,remove |
R5079 | T7169 | T7220 | themeOf | TRAF2,attract |
R5080 | T7169 | T7222 | causeOf | TRAF2,essential |
R5081 | T7169 | T7220 | themeOf | TRAF2,attract |
R5082 | T7170 | T7220 | themeOf | cIAP1,attract |
R5083 | T7170 | T7220 | themeOf | cIAP1,attract |
R5084 | T7170 | T7222 | causeOf | cIAP1,essential |
R5085 | T7171 | T7220 | themeOf | 2,attract |
R5086 | T7171 | T7220 | themeOf | 2,attract |
R5087 | T7171 | T7222 | causeOf | 2,essential |
R5088 | T7208 | T7209 | themeOf | oligomerisation,leading |
R5089 | T7172 | T7221 | themeOf | TRAF3,degradation |
R5090 | T7173 | T7223 | themeOf | NIK,releasing |
R5091 | T7173 | T7224 | themeOf | NIK,degradation |
R5092 | T7174 | T7225 | themeOf | NIK,accumulation |
R5093 | T7175 | T7226 | themeOf | IKK1,phosphorylation |
R5094 | T7212 | T7213 | themeOf | activate,ubiquitination-dependent |
R5095 | T7179 | T7229 | themeOf | CD40,binding |
R5096 | T7182 | T7229 | themeOf | TRAF2,binding |
R5097 | T7217 | T7218 | themeOf | degradation,leading |
R5098 | T7188 | T7230 | themeOf | CD40,mediated |
R5099 | T7189 | T7232 | causeOf | TRAF6,required |
R5100 | T7190 | T7233 | causeOf | CD40,mediated |
R5101 | T7191 | T7231 | themeOf | IL-6,production |
R5102 | T7217 | T7218 | themeOf | degradation,leading |
R5103 | T7221 | T7222 | themeOf | degradation,essential |
R5104 | T7198 | T7199 | themeOf | stimulation,modified |
R5105 | T7221 | T7222 | themeOf | degradation,essential |
R5106 | T7221 | T7222 | themeOf | degradation,essential |
R5107 | T7204 | T7206 | themeOf | recruitment,induces |
R5108 | T7204 | T7206 | themeOf | recruitment,induces |
R5109 | T7204 | T7206 | themeOf | recruitment,induces |
R5110 | T7223 | T7227 | themeOf | releasing,contributes |
R5111 | T7225 | T7228 | themeOf | accumulation,resulting |
R5112 | T7226 | T7228 | themeOf | phosphorylation,resulting |
R5113 | T7231 | T7232 | themeOf | production,required |
R5114 | T7231 | T7233 | themeOf | production,mediated |
R6255 | T9153 | T9162 | themeOf | IKK1,deficient |
R6256 | T9154 | T9163 | themeOf | IKK1,expressing |
R6257 | T9154 | T9164 | themeOf | IKK1,inactive |
R6258 | T9155 | T9165 | themeOf | IKK2,activation |
R6259 | T9156 | T9166 | themeOf | IκBα,degradation |
R6260 | T9157 | T9169 | themeOf | STAT1,phosphorylating |
R6261 | T9159 | T9170 | causeOf | IKK1,phosphorylates |
R6262 | T9160 | T9170 | themeOf | NIK,phosphorylates |
R6263 | T9165 | T9167 | themeOf | activation,result |
R6264 | T9165 | T9168 | themeOf | activation,enhanced |
R6265 | T9166 | T9167 | themeOf | degradation,result |
R8100 | T11852 | T11896 | themeOf | A20,association |
R8102 | T11884 | T11915 | themeOf | A20,association |
R8103 | T11884 | T11916 | themeOf | A20,mutations |
R8104 | T11853 | T11898 | themeOf | A20-binding inhibitor of NF-κB (ABIN) 1,ubiquitin-binding |
R8105 | T11853 | T11899 | causeOf | A20-binding inhibitor of NF-κB (ABIN) 1,requires |
R8106 | T11854 | T11898 | themeOf | Tax1-binding protein 1,ubiquitin-binding |
R8107 | T11855 | T11900 | themeOf | A20,inhibitor |
R8108 | T11892 | T11917 | themeOf | A20,affect |
R8109 | T11894 | T11918 | themeOf | A20,transcription |
R8110 | T11857 | T11901 | themeOf | A20,deficient |
R8111 | T11896 | T11897 | themeOf | association,targets |
R8112 | T11858 | T11902 | themeOf | A20,deficient |
R8113 | T11898 | T11899 | themeOf | ubiquitin-binding,requires |
R8114 | T11860 | T11903 | themeOf | A20,lacking |
R8115 | T11863 | T11904 | themeOf | A20,lacking |
R8116 | T11906 | T11907 | themeOf | expression,regulated |
R8117 | T11864 | T11905 | themeOf | A20,expression |
R8118 | T11865 | T11906 | themeOf | A20,expression |
R8119 | T11867 | T11908 | themeOf | A20,expressing |
R8120 | T11915 | T11916 | themeOf | association,mutations |
R8121 | T11868 | T11909 | themeOf | A20,expression |
R8122 | T11918 | T11919 | themeOf | transcription,repressed |
R8123 | T11869 | T11910 | themeOf | TNF,decreased |
R8124 | T11870 | T11910 | themeOf | IL-1β,decreased |
R8125 | T11871 | T11910 | themeOf | IL-6,decreased |
R8126 | T11872 | T11910 | themeOf | RANKL,decreased |
R8127 | T11873 | T11910 | themeOf | monocyte chemo-attractant protein 1,decreased |
R8128 | T11877 | T11911 | themeOf | TNF,decreased |
R8129 | T11878 | T11911 | themeOf | IL-1β,decreased |
R8130 | T11879 | T11912 | themeOf | A20,transduced |
R8132 | T11880 | T11913 | themeOf | A20,overexpression |
R8137 | T11882 | T11914 | themeOf | A20,lack |
R9177 | T13675 | T13706 | themeOf | A20,binding |
R9178 | T13677 | T13709 | themeOf | ABIN-2,interacting |
R9180 | T13682 | T13708 | themeOf | A20,expressed |
R9181 | T13682 | T13709 | themeOf | A20,interacting |
R9183 | T13684 | T13710 | themeOf | A20,target |
R9184 | T13685 | T13712 | causeOf | A20,dependent |
R9186 | T13686 | T13711 | themeOf | ABIN-1,expression |
R9190 | T13689 | T13713 | themeOf | ABIN-1,deficient |
R9191 | T13690 | T13714 | themeOf | ABIN-2,deficient |
R9192 | T13691 | T13715 | themeOf | ABIN-3,expressed |
R9193 | T13691 | T13717 | themeOf | ABIN-3,ubiquitin-binding |
R9194 | T13692 | T13716 | themeOf | truncated and inactive form,express |
R9201 | T13706 | T13707 | themeOf | binding,inhibitors |
R9202 | T13711 | T13712 | themeOf | expression,dependent |
R10680 | T16088 | T16101 | themeOf | IL-1R,inhibitor |
R10681 | T16088 | T16102 | themeOf | IL-1R,interaction |
R10682 | T16088 | T16102 | themeOf | IL-1R,interaction |
R10683 | T16088 | T16102 | themeOf | IL-1R,interaction |
R10684 | T16089 | T16101 | themeOf | MyD88,inhibitor |
R10685 | T16090 | T16101 | themeOf | IRAK1,inhibitor |
R10686 | T16091 | T16101 | themeOf | TRAF6,inhibitor |
R10687 | T16094 | T16103 | themeOf | SIGIRR,expression |
R10688 | T16094 | T16104 | themeOf | SIGIRR,expressed |
R10689 | T16095 | T16105 | themeOf | SIGIRR,overexpression |
R10690 | T16097 | T16106 | themeOf | SIGIRR,deficient |
R10691 | T16098 | T16107 | themeOf | SIGIRR,expression |
R10692 | T16099 | T16108 | themeOf | SIGIRR,compromised |
R10693 | T16100 | T16109 | themeOf | SIGIRR,expression |
R10694 | T16102 | T16101 | themeOf | interaction,inhibitor |
R10695 | T16102 | T16101 | themeOf | interaction,inhibitor |
R10696 | T16102 | T16101 | themeOf | interaction,inhibitor |
R11292 | T17045 | T17062 | themeOf | TRAF1,Expression |
R11293 | T17046 | T17063 | causeOf | TNF,inducible |
R11294 | T17047 | T17064 | themeOf | TRAF1,overexpression |
R11295 | T17050 | T17065 | themeOf | TRAF1,deficient |
R11296 | T17053 | T17066 | themeOf | TRAF1,deficient |
R11297 | T17056 | T17067 | themeOf | TRAF1,binding |
R11298 | T17057 | T17068 | themeOf | TRAF1,recruit |
R11299 | T17058 | T17068 | themeOf | A20,recruit |
R11300 | T17058 | T17069 | themeOf | A20,interact |
R11301 | T17061 | T17070 | themeOf | TRAF1,association |
R11302 | T17062 | T17063 | themeOf | Expression,inducible |
R12374 | T18556 | T18581 | themeOf | miR-146a,NF-κB-dependent |
R12375 | T18563 | T18582 | themeOf | miR-155,expressed |
R12376 | T18564 | T18583 | themeOf | miR-146a,overexpressed |
R12377 | T18565 | T18584 | themeOf | CD4,producing |
R12378 | T18566 | T18584 | themeOf | IL-17,producing |
R12379 | T18568 | T18585 | themeOf | miR-155,overexpression |
R12380 | T18569 | T18587 | causeOf | miR-155,promote |
R12381 | T18570 | T18586 | themeOf | TNF,production |
R12382 | T18573 | T18589 | themeOf | miR-124a,decreased |
R12383 | T18574 | T18588 | themeOf | monocyte chemoattractant protein 1,regulator |
R12384 | T18576 | T18590 | themeOf | matrix metalloproteinase-1,secretion |
R12385 | T18577 | T18590 | themeOf | IL-6,secretion |
R12386 | T18578 | T18593 | themeOf | miR-16,expression |
R12387 | T18579 | T18593 | themeOf | miR-132,expression |
R12388 | T18580 | T18593 | themeOf | miR-223,expression |
R12389 | T18586 | T18587 | themeOf | production,promote |
R12390 | T18590 | T18591 | themeOf | secretion,leading |
R12391 | T18590 | T18592 | themeOf | secretion,increased |
R12392 | T18590 | T18591 | themeOf | secretion,leading |
R12393 | T18590 | T18592 | themeOf | secretion,increased |
R13713 | T20677 | T20716 | themeOf | RIP1,polyubiquitination |
R13714 | T20678 | T20716 | themeOf | IRAK1,polyubiquitination |
R13715 | T20680 | T20717 | themeOf | IKK2,recruitment |
R13716 | T20681 | T20717 | themeOf | TAK1,recruitment |
R13717 | T20682 | T20719 | causeOf | TAK1,activates |
R13718 | T20683 | T20719 | themeOf | IKK2,activates |
R13719 | T20683 | T20720 | themeOf | IKK2,phosphorylates |
R13720 | T20684 | T20720 | themeOf | IκBα,phosphorylates |
R13721 | T20685 | T20721 | themeOf | p65,heterodimer |
R13722 | T20686 | T20721 | themeOf | p50,heterodimer |
R13723 | T20690 | T20722 | themeOf | RIP1,recruited |
R13724 | T20690 | T20722 | themeOf | RIP1,recruited |
R13725 | T20691 | T20722 | themeOf | TRAF6,recruited |
R13726 | T20692 | T20722 | themeOf | ABIN-1,recruited |
R13727 | T20692 | T20722 | themeOf | ABIN-1,recruited |
R13728 | T20693 | T20722 | themeOf | p62,recruited |
R13729 | T20694 | T20723 | themeOf | IRAK1,expression |
R13730 | T20695 | T20723 | themeOf | TRAF6,expression |
R13731 | T20696 | T20725 | themeOf | SIGIRR,compete |
R13732 | T20697 | T20725 | themeOf | TLR4,compete |
R13733 | T20698 | T20726 | themeOf | IRAK1,binding |
R13734 | T20699 | T20726 | themeOf | TRAF6,binding |
R13735 | T20717 | T20718 | themeOf | recruitment,activation |
R13736 | T20723 | T20724 | themeOf | expression,inhibiting |
R13737 | T20723 | T20724 | themeOf | expression,inhibiting |
R14470 | T22158 | T22190 | themeOf | NF-κB inducing kinase,expression |
R14471 | T22159 | T22190 | themeOf | NIK,expression |
R14472 | T22160 | T22192 | themeOf | NIK,polyubiquitination |
R14473 | T22160 | T22193 | themeOf | NIK,degradation |
R14474 | T22161 | T22194 | themeOf | NIK,low |
R14475 | T22167 | T22196 | themeOf | TRAF3,recruited |
R14476 | T22168 | T22199 | causeOf | TRAF2,directs |
R14477 | T22168 | T22199 | causeOf | TRAF2,directs |
R14478 | T22168 | T22199 | causeOf | TRAF2,directs |
R14479 | T22168 | T22199 | causeOf | TRAF2,directs |
R14480 | T22169 | T22197 | themeOf | cIAP1,nondegradative |
R14481 | T22169 | T22198 | themeOf | cIAP1,polyubiquitination |
R14482 | T22170 | T22197 | themeOf | 2,nondegradative |
R14483 | T22170 | T22198 | themeOf | 2,polyubiquitination |
R14484 | T22171 | T22200 | themeOf | cIAP1,polyubiquitination |
R14485 | T22173 | T22200 | themeOf | TRAF3,polyubiquitination |
R14486 | T22175 | T22201 | themeOf | TRAF3,degraded |
R14487 | T22176 | T22202 | themeOf | NIK,stabilised |
R14488 | T22177 | T22203 | themeOf | NIK,resulting |
R14489 | T22177 | T22204 | themeOf | NIK,increased |
R14490 | T22178 | T22205 | causeOf | NIK,activates |
R14491 | T22179 | T22205 | themeOf | IKK1,activates |
R14492 | T22179 | T22206 | themeOf | IKK1,mediates |
R14493 | T22180 | T22207 | themeOf | p100,phosphorylation |
R14494 | T22181 | T22208 | themeOf | p100,degradation |
R14495 | T22182 | T22208 | themeOf | p52,degradation |
R14496 | T22183 | T22209 | themeOf | RelB,heterodimer |
R14497 | T22185 | T22210 | themeOf | TRAF1,regulator |
R14498 | T22186 | T22211 | themeOf | RANK,inhibitor |
R14499 | T22187 | T22211 | themeOf | receptor activator of NF-κB,inhibitor |
R14500 | T22188 | T22211 | themeOf | TNF,inhibitor |
R14501 | T22189 | T22211 | themeOf | tumour necrosis factor,inhibitor |
R14502 | T22190 | T22191 | themeOf | expression,dependent |
R14503 | T22190 | T22191 | themeOf | expression,dependent |
R14504 | T22192 | T22195 | themeOf | polyubiquitination,facilitates |
R14505 | T22193 | T22195 | themeOf | degradation,facilitates |
R14506 | T22197 | T22198 | themeOf | nondegradative,polyubiquitination |
R14507 | T22197 | T22198 | themeOf | nondegradative,polyubiquitination |
R14508 | T22198 | T22199 | themeOf | polyubiquitination,directs |
R14509 | T22198 | T22199 | themeOf | polyubiquitination,directs |
R14510 | T22198 | T22199 | themeOf | polyubiquitination,directs |
R14511 | T22198 | T22199 | themeOf | polyubiquitination,directs |
R14512 | T22204 | T22203 | themeOf | increased,resulting |
R14513 | T22207 | T22206 | themeOf | phosphorylation,mediates |
R1113 | T1382 | T1402 | causeOf | p100,regulate |
R1114 | T1382 | T1402 | causeOf | p100,regulate |
R1115 | T1382 | T1402 | causeOf | p100,regulate |
R1116 | T1382 | T1402 | causeOf | p100,regulate |
R1117 | T1383 | T1401 | themeOf | IL-6,expression |
R1118 | T1384 | T1401 | themeOf | cyclo-oxygenase-2,expression |
R1119 | T1385 | T1401 | themeOf | inducible nitric oxide synthase,expression |
R1120 | T1393 | T1401 | themeOf | TNF,expression |
R1121 | T1395 | T1403 | themeOf | receptor activator of NF-κB ligand,effects |
R1122 | T1401 | T1402 | themeOf | expression,regulate |
R1123 | T1401 | T1402 | themeOf | expression,regulate |
R1124 | T1401 | T1402 | themeOf | expression,regulate |
R1125 | T1401 | T1402 | themeOf | expression,regulate |
R1126 | T1403 | T1404 | themeOf | effects,mediating |
R2683 | T3363 | T3390 | themeOf | receptor activator of NF-κB,activation |
R2684 | T3366 | T3391 | themeOf | CD40,expressed |
R9204 | T13711 | T13712 | themeOf | expression,dependent |
R9205 | T13711 | T13712 | themeOf | expression,dependent |
R9206 | T13717 | T13718 | themeOf | ubiquitin-binding,lacking |
R9207 | T13721 | T13722 | themeOf | expression,depend |
R9200 | T13704 | T13721 | themeOf | A20,expression |
R9208 | T13721 | T13722 | themeOf | expression,depend |
R10051 | T15088 | T15106 | themeOf | A20,expressed |
R10052 | T15092 | T15107 | themeOf | CYLD,deficiency |
R10053 | T15094 | T15108 | themeOf | CYLD,expression |
R10054 | T15096 | T15110 | themeOf | TRAF6,recruited |
R10055 | T15096 | T15111 | themeOf | TRAF6,ubiquitinated |
R10056 | T15097 | T15112 | themeOf | ubiquitin,binding |
R10057 | T15098 | T15110 | themeOf | p62,recruited |
R10058 | T15098 | T15112 | themeOf | p62,binding |
R10059 | T15101 | T15113 | themeOf | TRAF6,deubiquitination |
R10060 | T15102 | T15114 | themeOf | p62,expressing |
R10061 | T15108 | T15109 | themeOf | expression,upregulated |
R10677 | T16085 | T16102 | themeOf | Single-immunoglobulin IL-1 receptor-related,interaction |
R10678 | T16086 | T16102 | themeOf | SIGIRR,interaction |
R10679 | T16087 | T16102 | themeOf | TIR-8,interaction |
bionlp-st-ge-2016-uniprot
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T22106 | 15106-15136 | http://www.uniprot.org/uniprot/Q9Y4K3 | denotes | TNF receptor-associated factor |
T22105 | 15138-15141 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T22104 | 15106-15109 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T22103 | 14956-14959 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T22102 | 14799-14803 | http://www.uniprot.org/uniprot/Q01201 | denotes | RelB |
T22101 | 14763-14766 | http://www.uniprot.org/uniprot/Q00653 | denotes | p52 |
T22100 | 14755-14759 | http://www.uniprot.org/uniprot/Q00653 | denotes | p100 |
T22099 | 14644-14648 | http://www.uniprot.org/uniprot/Q00653 | denotes | p100 |
T22098 | 15033-15043 | http://www.uniprot.org/uniprot/Q60680-2 | denotes | IκB kinase |
T22097 | 14617-14621 | http://www.uniprot.org/uniprot/Q60680-2 | denotes | IKK1 |
T22096 | 15033-15043 | http://www.uniprot.org/uniprot/O15111 | denotes | IκB kinase |
T22095 | 14617-14621 | http://www.uniprot.org/uniprot/O15111 | denotes | IKK1 |
T22094 | 14401-14406 | http://www.uniprot.org/uniprot/Q13490 | denotes | cIAP1 |
T22093 | 14348-14353 | http://www.uniprot.org/uniprot/Q13490 | denotes | cIAP1 |
T22092 | 14102-14107 | http://www.uniprot.org/uniprot/Q13490 | denotes | cIAP1 |
T22091 | 15106-15136 | http://www.uniprot.org/uniprot/Q13114 | denotes | TNF receptor-associated factor |
T22090 | 14839-14844 | http://www.uniprot.org/uniprot/Q13114 | denotes | TRAF3 |
T22089 | 14491-14496 | http://www.uniprot.org/uniprot/Q13114 | denotes | TRAF3 |
T22088 | 14454-14459 | http://www.uniprot.org/uniprot/Q13114 | denotes | TRAF3 |
T22087 | 14244-14249 | http://www.uniprot.org/uniprot/Q13114 | denotes | TRAF3 |
T22086 | 14092-14097 | http://www.uniprot.org/uniprot/Q13114 | denotes | TRAF3 |
T22085 | 15106-15136 | http://www.uniprot.org/uniprot/Q12933 | denotes | TNF receptor-associated factor |
T22084 | 14286-14291 | http://www.uniprot.org/uniprot/Q12933 | denotes | TRAF2 |
T22083 | 14085-14090 | http://www.uniprot.org/uniprot/Q12933 | denotes | TRAF2 |
T22082 | 14579-14582 | http://www.uniprot.org/uniprot/Q99558 | denotes | NIK |
T22081 | 14555-14558 | http://www.uniprot.org/uniprot/Q99558 | denotes | NIK |
T22080 | 14513-14516 | http://www.uniprot.org/uniprot/Q99558 | denotes | NIK |
T22079 | 14473-14476 | http://www.uniprot.org/uniprot/Q99558 | denotes | NIK |
T22078 | 14207-14210 | http://www.uniprot.org/uniprot/Q99558 | denotes | NIK |
T22077 | 14194-14197 | http://www.uniprot.org/uniprot/Q99558 | denotes | NIK |
T22076 | 14028-14031 | http://www.uniprot.org/uniprot/Q99558 | denotes | NIK |
T22075 | 13982-13985 | http://www.uniprot.org/uniprot/Q99558 | denotes | NIK |
T22074 | 13880-13884 | http://www.uniprot.org/uniprot/P25942 | denotes | CD40 |
T20589 | 10299-10309 | http://www.uniprot.org/uniprot/Q60680-2 | denotes | IκB kinase |
T20588 | 10299-10309 | http://www.uniprot.org/uniprot/O15111 | denotes | IκB kinase |
T20587 | 9760-9766 | http://www.uniprot.org/uniprot/Q15025 | denotes | ABIN-1 |
T20586 | 10200-10203 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T20585 | 9534-9537 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T20584 | 9329-9332 | http://www.uniprot.org/uniprot/P19838 | denotes | p50 |
T20583 | 9321-9324 | http://www.uniprot.org/uniprot/P21579 | denotes | p65 |
T20582 | 9321-9324 | http://www.uniprot.org/uniprot/Q04206 | denotes | p65 |
T20581 | 9195-9199 | http://www.uniprot.org/uniprot/P25963 | denotes | IκBα |
T20580 | 9160-9164 | http://www.uniprot.org/uniprot/O14920 | denotes | IKK2 |
T20579 | 9106-9110 | http://www.uniprot.org/uniprot/O14920 | denotes | IKK2 |
T20578 | 10424-10428 | http://www.uniprot.org/uniprot/Q9Y6K9 | denotes | NEMO |
T20577 | 9023-9027 | http://www.uniprot.org/uniprot/Q9Y6K9 | denotes | NEMO |
T20576 | 8919-8924 | http://www.uniprot.org/uniprot/Q13490 | denotes | cIAP1 |
T20575 | 10031-10036 | http://www.uniprot.org/uniprot/Q9Y4K3 | denotes | TRAF6 |
T20574 | 9871-9876 | http://www.uniprot.org/uniprot/Q9Y4K3 | denotes | TRAF6 |
T20573 | 9667-9672 | http://www.uniprot.org/uniprot/Q9Y4K3 | denotes | TRAF6 |
T20572 | 8912-8917 | http://www.uniprot.org/uniprot/Q9Y4K3 | denotes | TRAF6 |
T20571 | 8905-8910 | http://www.uniprot.org/uniprot/Q12933 | denotes | TRAF2 |
T20570 | 10512-10516 | http://www.uniprot.org/uniprot/Q13546 | denotes | RIP1 |
T20569 | 9658-9662 | http://www.uniprot.org/uniprot/Q13546 | denotes | RIP1 |
T20568 | 8990-8994 | http://www.uniprot.org/uniprot/Q13546 | denotes | RIP1 |
T20567 | 8861-8865 | http://www.uniprot.org/uniprot/Q13546 | denotes | RIP1 |
T20566 | 8794-8797 | http://www.uniprot.org/uniprot/P01732 | denotes | MAL |
T20565 | 10367-10372 | http://www.uniprot.org/uniprot/Q99836 | denotes | MyD88 |
T20564 | 8787-8792 | http://www.uniprot.org/uniprot/Q99836 | denotes | MyD88 |
T20563 | 10696-10699 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T20562 | 10639-10642 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T20561 | 8731-8734 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T20560 | 10001-10005 | http://www.uniprot.org/uniprot/O00206 | denotes | TLR4 |
T20559 | 8672-8676 | http://www.uniprot.org/uniprot/O00206 | denotes | TLR4 |
T20558 | 8656-8660 | http://www.uniprot.org/uniprot/P25942 | denotes | CD40 |
T18508 | 32575-32579 | http://www.uniprot.org/uniprot/P05231 | denotes | IL-6 |
T18507 | 31263-31268 | http://www.uniprot.org/uniprot/Q16552 | denotes | IL-17 |
T18506 | 31254-31257 | http://www.uniprot.org/uniprot/P01730 | denotes | CD4 |
T18505 | 31015-31019 | http://www.uniprot.org/uniprot/Q13546 | denotes | RIP1 |
T18504 | 30853-30858 | http://www.uniprot.org/uniprot/Q9Y4K3 | denotes | TRAF6 |
T18503 | 31680-31683 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T18502 | 30736-30739 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T18501 | 30729-30734 | http://www.uniprot.org/uniprot/P01584 | denotes | IL-1β |
T17010 | 29728-29731 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T17009 | 29426-29431 | http://www.uniprot.org/uniprot/Q12933 | denotes | TRAF2 |
T17008 | 29299-29303 | http://www.uniprot.org/uniprot/P25942 | denotes | CD40 |
T17007 | 29170-29173 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T17006 | 29092-29095 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T17005 | 29051-29054 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T17004 | 28943-28946 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T17003 | 28655-28658 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T16058 | 27666-27671 | http://www.uniprot.org/uniprot/Q9Y4K3 | denotes | TRAF6 |
T16057 | 27650-27655 | http://www.uniprot.org/uniprot/Q99836 | denotes | MyD88 |
T15028 | 26824-26838 | http://www.uniprot.org/uniprot/Q13501 | denotes | sequestosome 1 |
T15027 | 25985-25988 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T15026 | 25933-25936 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T15025 | 25884-25887 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T15024 | 25834-25838 | http://www.uniprot.org/uniprot/Q13546 | denotes | RIP1 |
T15023 | 26896-26901 | http://www.uniprot.org/uniprot/Q9Y4K3 | denotes | TRAF6 |
T15022 | 26757-26762 | http://www.uniprot.org/uniprot/Q9Y4K3 | denotes | TRAF6 |
T15021 | 25820-25825 | http://www.uniprot.org/uniprot/Q9Y4K3 | denotes | TRAF6 |
T15020 | 25813-25818 | http://www.uniprot.org/uniprot/Q12933 | denotes | TRAF2 |
T15019 | 25807-25811 | http://www.uniprot.org/uniprot/Q9Y6K9 | denotes | NEMO |
T13627 | 24076-24079 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T13626 | 23962-23965 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T13625 | 23883-23886 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T13624 | 23080-23083 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T13623 | 23516-23522 | http://www.uniprot.org/uniprot/Q8NFZ5 | denotes | ABIN-2 |
T13622 | 22906-22912 | http://www.uniprot.org/uniprot/Q8NFZ5 | denotes | ABIN-2 |
T13621 | 24679-24685 | http://www.uniprot.org/uniprot/Q15025 | denotes | ABIN-1 |
T13620 | 24217-24223 | http://www.uniprot.org/uniprot/Q15025 | denotes | ABIN-1 |
T13619 | 24136-24142 | http://www.uniprot.org/uniprot/Q15025 | denotes | ABIN-1 |
T13618 | 24048-24054 | http://www.uniprot.org/uniprot/Q15025 | denotes | ABIN-1 |
T13617 | 23915-23921 | http://www.uniprot.org/uniprot/Q15025 | denotes | ABIN-1 |
T13616 | 23853-23859 | http://www.uniprot.org/uniprot/Q15025 | denotes | ABIN-1 |
T13615 | 23495-23501 | http://www.uniprot.org/uniprot/Q15025 | denotes | ABIN-1 |
T13614 | 23297-23303 | http://www.uniprot.org/uniprot/Q15025 | denotes | ABIN-1 |
T13613 | 22898-22904 | http://www.uniprot.org/uniprot/Q15025 | denotes | ABIN-1 |
T13612 | 24537-24540 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T13611 | 24239-24242 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T13610 | 23848-23851 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T13609 | 23383-23386 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T13608 | 23292-23295 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T13607 | 23236-23239 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T13606 | 23009-23012 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T13605 | 22866-22869 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11743 | 20680-20685 | http://www.uniprot.org/uniprot/Q16552 | denotes | IL-17 |
T11742 | 20618-20622 | http://www.uniprot.org/uniprot/P05231 | denotes | IL-6 |
T11741 | 21004-21009 | http://www.uniprot.org/uniprot/P01584 | denotes | IL-1β |
T11740 | 20869-20874 | http://www.uniprot.org/uniprot/P01584 | denotes | IL-1β |
T11739 | 20611-20616 | http://www.uniprot.org/uniprot/P01584 | denotes | IL-1β |
T11738 | 18887-18904 | http://www.uniprot.org/uniprot/Q9UFW8 | denotes | binding protein 1 |
T11737 | 18887-18904 | http://www.uniprot.org/uniprot/Q13541 | denotes | binding protein 1 |
T11736 | 18887-18904 | http://www.uniprot.org/uniprot/Q86VP1 | denotes | binding protein 1 |
T11735 | 18887-18904 | http://www.uniprot.org/uniprot/O00560 | denotes | binding protein 1 |
T11734 | 18870-18877 | http://www.uniprot.org/uniprot/Q15025 | denotes | ABIN) 1 |
T11733 | 18628-18633 | http://www.uniprot.org/uniprot/Q13490 | denotes | cIAP1 |
T11732 | 18618-18623 | http://www.uniprot.org/uniprot/Q12933 | denotes | TRAF2 |
T11731 | 18404-18409 | http://www.uniprot.org/uniprot/Q9UDY8 | denotes | MALT1 |
T11730 | 18611-18616 | http://www.uniprot.org/uniprot/Q9Y4K3 | denotes | TRAF6 |
T11729 | 18394-18399 | http://www.uniprot.org/uniprot/Q9Y4K3 | denotes | TRAF6 |
T11728 | 18382-18386 | http://www.uniprot.org/uniprot/Q13546 | denotes | RIP1 |
T11727 | 22176-22179 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T11726 | 22151-22154 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T11725 | 20996-20999 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T11724 | 20861-20864 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T11723 | 20606-20609 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T11722 | 19643-19646 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T11721 | 19360-19363 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T11720 | 18132-18135 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T11719 | 17972-17979 | http://www.uniprot.org/uniprot/P21580 | denotes | TNFAIP3 |
T11718 | 22555-22558 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11717 | 22507-22510 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11716 | 22327-22330 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11715 | 22246-22249 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11714 | 22116-22119 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11713 | 22029-22032 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11712 | 21982-21985 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11711 | 21828-21831 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11710 | 21607-21610 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11709 | 21461-21464 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11708 | 21257-21260 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11707 | 21162-21165 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11706 | 21013-21016 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11705 | 20703-20706 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11704 | 20499-20502 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11703 | 20271-20274 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11702 | 20168-20171 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11701 | 20106-20109 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11700 | 19929-19932 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11699 | 19798-19801 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11698 | 19677-19680 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11697 | 19483-19486 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11696 | 19311-19314 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11695 | 19126-19129 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11694 | 19062-19065 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11693 | 18964-18967 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11692 | 18838-18841 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11691 | 18753-18756 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11690 | 18691-18694 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11689 | 18275-18278 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11688 | 17953-17956 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T11687 | 17941-17944 | http://www.uniprot.org/uniprot/P21580 | denotes | A20 |
T9127 | 17680-17683 | http://www.uniprot.org/uniprot/Q99558 | denotes | NIK |
T9126 | 17457-17461 | http://www.uniprot.org/uniprot/P25963 | denotes | IκBα |
T9125 | 17437-17441 | http://www.uniprot.org/uniprot/O14920 | denotes | IKK2 |
T9124 | 17781-17785 | http://www.uniprot.org/uniprot/Q60680-2 | denotes | IKK1 |
T9123 | 17660-17664 | http://www.uniprot.org/uniprot/Q60680-2 | denotes | IKK1 |
T9122 | 17480-17484 | http://www.uniprot.org/uniprot/Q60680-2 | denotes | IKK1 |
T9121 | 17353-17357 | http://www.uniprot.org/uniprot/Q60680-2 | denotes | IKK1 |
T9120 | 17297-17301 | http://www.uniprot.org/uniprot/Q60680-2 | denotes | IKK1 |
T9119 | 17069-17073 | http://www.uniprot.org/uniprot/Q60680-2 | denotes | IKK1 |
T9118 | 17781-17785 | http://www.uniprot.org/uniprot/O15111 | denotes | IKK1 |
T9117 | 17660-17664 | http://www.uniprot.org/uniprot/O15111 | denotes | IKK1 |
T9116 | 17480-17484 | http://www.uniprot.org/uniprot/O15111 | denotes | IKK1 |
T9115 | 17353-17357 | http://www.uniprot.org/uniprot/O15111 | denotes | IKK1 |
T9114 | 17297-17301 | http://www.uniprot.org/uniprot/O15111 | denotes | IKK1 |
T9113 | 17069-17073 | http://www.uniprot.org/uniprot/O15111 | denotes | IKK1 |
T6913 | 13389-13394 | http://www.uniprot.org/uniprot/Q13490 | denotes | cIAP1 |
T6912 | 11276-11281 | http://www.uniprot.org/uniprot/Q13490 | denotes | cIAP1 |
T6911 | 15803-15808 | http://www.uniprot.org/uniprot/Q12933 | denotes | TRAF2 |
T6910 | 15489-15494 | http://www.uniprot.org/uniprot/Q12933 | denotes | TRAF2 |
T6909 | 15415-15420 | http://www.uniprot.org/uniprot/Q12933 | denotes | TRAF2 |
T6908 | 13618-13623 | http://www.uniprot.org/uniprot/Q12933 | denotes | TRAF2 |
T6907 | 13371-13376 | http://www.uniprot.org/uniprot/Q12933 | denotes | TRAF2 |
T6906 | 11264-11269 | http://www.uniprot.org/uniprot/Q12933 | denotes | TRAF2 |
T6905 | 12533-12537 | http://www.uniprot.org/uniprot/Q13546 | denotes | RIP1 |
T6904 | 11405-11409 | http://www.uniprot.org/uniprot/Q13546 | denotes | RIP1 |
T6903 | 11308-11312 | http://www.uniprot.org/uniprot/Q13546 | denotes | RIP1 |
T6902 | 11203-11207 | http://www.uniprot.org/uniprot/Q13546 | denotes | RIP1 |
T6901 | 10935-10939 | http://www.uniprot.org/uniprot/Q13546 | denotes | RIP1 |
T6900 | 11621-11625 | http://www.uniprot.org/uniprot/Q9Y6K9 | denotes | NEMO |
T6899 | 11515-11519 | http://www.uniprot.org/uniprot/Q9Y6K9 | denotes | NEMO |
T6898 | 8460-8464 | http://www.uniprot.org/uniprot/Q9Y6K9 | denotes | NEMO |
T6897 | 8373-8377 | http://www.uniprot.org/uniprot/Q9Y6K9 | denotes | NEMO |
T6896 | 8313-8317 | http://www.uniprot.org/uniprot/O14920 | denotes | IKKβ |
T6895 | 8284-8288 | http://www.uniprot.org/uniprot/O14920 | denotes | IKK2 |
T6894 | 13798-13802 | http://www.uniprot.org/uniprot/Q60680-2 | denotes | IKK1 |
T6893 | 13107-13111 | http://www.uniprot.org/uniprot/Q60680-2 | denotes | IKK1 |
T6892 | 8474-8478 | http://www.uniprot.org/uniprot/Q60680-2 | denotes | IKK1 |
T6891 | 8275-8279 | http://www.uniprot.org/uniprot/Q60680-2 | denotes | IKK1 |
T6890 | 8051-8061 | http://www.uniprot.org/uniprot/Q60680-2 | denotes | IκB kinase |
T6889 | 13798-13802 | http://www.uniprot.org/uniprot/O15111 | denotes | IKK1 |
T6888 | 13107-13111 | http://www.uniprot.org/uniprot/O15111 | denotes | IKK1 |
T6887 | 8474-8478 | http://www.uniprot.org/uniprot/O15111 | denotes | IKK1 |
T6886 | 8275-8279 | http://www.uniprot.org/uniprot/O15111 | denotes | IKK1 |
T6885 | 8051-8061 | http://www.uniprot.org/uniprot/O15111 | denotes | IκB kinase |
T6884 | 12662-12665 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T6883 | 11680-11683 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T6882 | 11184-11187 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T6881 | 11167-11170 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T6880 | 11006-11009 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T6879 | 10841-10844 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T6878 | 10795-10798 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T6877 | 10782-10785 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T6876 | 7808-7811 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T6875 | 12863-12866 | http://www.uniprot.org/uniprot/Q00653 | denotes | p52 |
T6874 | 7473-7476 | http://www.uniprot.org/uniprot/Q00653 | denotes | p52 |
T6873 | 7437-7441 | http://www.uniprot.org/uniprot/Q00653 | denotes | p100 |
T6872 | 7306-7310 | http://www.uniprot.org/uniprot/Q00653 | denotes | p100 |
T6871 | 7481-7484 | http://www.uniprot.org/uniprot/P19838 | denotes | p50 |
T6870 | 7446-7450 | http://www.uniprot.org/uniprot/P19838 | denotes | p105 |
T6869 | 7277-7281 | http://www.uniprot.org/uniprot/P19838 | denotes | p105 |
T6868 | 7446-7450 | http://www.uniprot.org/uniprot/Q14511 | denotes | p105 |
T6867 | 7277-7281 | http://www.uniprot.org/uniprot/Q14511 | denotes | p105 |
T6866 | 7271-7275 | http://www.uniprot.org/uniprot/O00221 | denotes | IκBε |
T6865 | 7265-7269 | http://www.uniprot.org/uniprot/Q15653 | denotes | IκBβ |
T6941 | 15780-15784 | http://www.uniprot.org/uniprot/P05231 | denotes | IL-6 |
T6940 | 15340-15352 | http://www.uniprot.org/uniprot/P29965 | denotes | ligand, CD40 |
T6939 | 15850-15855 | http://www.uniprot.org/uniprot/Q13114 | denotes | TRAF3 |
T6938 | 15499-15504 | http://www.uniprot.org/uniprot/Q13114 | denotes | TRAF3 |
T6937 | 15422-15427 | http://www.uniprot.org/uniprot/Q13114 | denotes | TRAF3 |
T6936 | 13672-13677 | http://www.uniprot.org/uniprot/Q13114 | denotes | TRAF3 |
T6935 | 13540-13545 | http://www.uniprot.org/uniprot/Q13114 | denotes | TRAF3 |
T6934 | 13378-13383 | http://www.uniprot.org/uniprot/Q13114 | denotes | TRAF3 |
T6933 | 13777-13780 | http://www.uniprot.org/uniprot/Q99558 | denotes | NIK |
T6932 | 13725-13728 | http://www.uniprot.org/uniprot/Q99558 | denotes | NIK |
T6931 | 13426-13429 | http://www.uniprot.org/uniprot/Q99558 | denotes | NIK |
T6930 | 13330-13333 | http://www.uniprot.org/uniprot/Q99558 | denotes | NIK |
T6929 | 13185-13188 | http://www.uniprot.org/uniprot/Q99558 | denotes | NIK |
T6928 | 13179-13182 | http://www.uniprot.org/uniprot/Q99558 | denotes | NIK |
T6927 | 12892-12896 | http://www.uniprot.org/uniprot/Q01201 | denotes | RelB |
T6926 | 15890-15894 | http://www.uniprot.org/uniprot/P25942 | denotes | CD40 |
T6925 | 15747-15751 | http://www.uniprot.org/uniprot/P25942 | denotes | CD40 |
T6924 | 15676-15680 | http://www.uniprot.org/uniprot/P25942 | denotes | CD40 |
T6923 | 15348-15352 | http://www.uniprot.org/uniprot/P25942 | denotes | CD40 |
T6922 | 15195-15199 | http://www.uniprot.org/uniprot/P25942 | denotes | CD40 |
T6921 | 12780-12784 | http://www.uniprot.org/uniprot/P25942 | denotes | CD40 |
T6920 | 15725-15730 | http://www.uniprot.org/uniprot/Q9Y4K3 | denotes | TRAF6 |
T6919 | 15440-15445 | http://www.uniprot.org/uniprot/Q9Y4K3 | denotes | TRAF6 |
T6918 | 12518-12523 | http://www.uniprot.org/uniprot/Q9Y4K3 | denotes | TRAF6 |
T6917 | 12487-12492 | http://www.uniprot.org/uniprot/Q9Y4K3 | denotes | TRAF6 |
T6916 | 12427-12432 | http://www.uniprot.org/uniprot/Q9Y4K3 | denotes | TRAF6 |
T6915 | 11994-11998 | http://www.uniprot.org/uniprot/O00206 | denotes | TLR4 |
T6914 | 13628-13633 | http://www.uniprot.org/uniprot/Q13490 | denotes | cIAP1 |
T3287 | 6565-6569 | http://www.uniprot.org/uniprot/O00206 | denotes | TLR4 |
T3286 | 6099-6103 | http://www.uniprot.org/uniprot/O00206 | denotes | TLR4 |
T3285 | 4302-4305 | http://www.uniprot.org/uniprot/P01730 | denotes | CD4 |
T3284 | 4532-4537 | http://www.uniprot.org/uniprot/P29965 | denotes | CD154 |
T3283 | 4235-4240 | http://www.uniprot.org/uniprot/P29965 | denotes | CD154 |
T3282 | 4222-4233 | http://www.uniprot.org/uniprot/P29965 | denotes | CD40 ligand |
T3281 | 4576-4580 | http://www.uniprot.org/uniprot/P25942 | denotes | CD40 |
T3280 | 4519-4523 | http://www.uniprot.org/uniprot/P25942 | denotes | CD40 |
T3279 | 4222-4226 | http://www.uniprot.org/uniprot/P25942 | denotes | CD40 |
T3278 | 3903-3907 | http://www.uniprot.org/uniprot/P25942 | denotes | CD40 |
T3277 | 4783-4786 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T3276 | 4197-4200 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T3275 | 3919-3922 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T3274 | 3702-3705 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T3273 | 3450-3453 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T3272 | 3375-3378 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T3271 | 3316-3319 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T1278 | 2953-2960 | http://www.uniprot.org/uniprot/P21580 | denotes | TNFAIP3 |
T1277 | 2940-2944 | http://www.uniprot.org/uniprot/P25942 | denotes | CD40 |
T1276 | 1895-1899 | http://www.uniprot.org/uniprot/P05231 | denotes | IL-6 |
T1275 | 2035-2038 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T1274 | 1884-1887 | http://www.uniprot.org/uniprot/P01375 | denotes | TNF |
T1273 | 2968-2971 | http://www.uniprot.org/uniprot/Q04864 | denotes | REL |
T1272 | 1758-1763 | http://www.uniprot.org/uniprot/Q04864 | denotes | c-Rel |
T1271 | 1752-1756 | http://www.uniprot.org/uniprot/Q01201 | denotes | RelB |
T1270 | 1739-1742 | http://www.uniprot.org/uniprot/P21579 | denotes | p65 |
T1269 | 1739-1742 | http://www.uniprot.org/uniprot/Q04206 | denotes | p65 |
T1268 | 1723-1727 | http://www.uniprot.org/uniprot/P19838 | denotes | p105 |
T1267 | 1723-1727 | http://www.uniprot.org/uniprot/Q14511 | denotes | p105 |
T1266 | 1707-1711 | http://www.uniprot.org/uniprot/Q00653 | denotes | p100 |
bionlp-st-ge-2016-test-proteins
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T21531 | 15143-15165 | Protein | denotes | tumour necrosis factor |
T21530 | 15138-15141 | Protein | denotes | TNF |
T21529 | 15071-15098 | Protein | denotes | receptor activator of NF-κB |
T21528 | 15065-15069 | Protein | denotes | RANK |
T21527 | 14846-14851 | Protein | denotes | TRAF1 |
T21526 | 14839-14844 | Protein | denotes | TRAF3 |
T21525 | 14799-14803 | Protein | denotes | RelB |
T21524 | 14763-14766 | Protein | denotes | p52 |
T21523 | 14755-14759 | Protein | denotes | p100 |
T21522 | 14644-14648 | Protein | denotes | p100 |
T21521 | 14617-14621 | Protein | denotes | IKK1 |
T21520 | 14579-14582 | Protein | denotes | NIK |
T21519 | 14555-14558 | Protein | denotes | NIK |
T21518 | 14513-14516 | Protein | denotes | NIK |
T21517 | 14491-14496 | Protein | denotes | TRAF3 |
T21516 | 14473-14476 | Protein | denotes | NIK |
T21515 | 14454-14459 | Protein | denotes | TRAF3 |
T21514 | 14407-14408 | Protein | denotes | 2 |
T21513 | 14401-14406 | Protein | denotes | cIAP1 |
T21512 | 14354-14355 | Protein | denotes | 2 |
T21511 | 14348-14353 | Protein | denotes | cIAP1 |
T21510 | 14286-14291 | Protein | denotes | TRAF2 |
T21509 | 14244-14249 | Protein | denotes | TRAF3 |
T21508 | 14207-14210 | Protein | denotes | NIK |
T21507 | 14194-14197 | Protein | denotes | NIK |
T21506 | 14108-14109 | Protein | denotes | 2 |
T21505 | 14102-14107 | Protein | denotes | cIAP1 |
T21504 | 14092-14097 | Protein | denotes | TRAF3 |
T21503 | 14085-14090 | Protein | denotes | TRAF2 |
T21502 | 14028-14031 | Protein | denotes | NIK |
T21501 | 13982-13985 | Protein | denotes | NIK |
T21500 | 13959-13980 | Protein | denotes | NF-κB inducing kinase |
T21499 | 13889-13893 | Protein | denotes | RANK |
T21498 | 13880-13884 | Protein | denotes | CD40 |
T19639 | 10701-10723 | Protein | denotes | tumour necrosis factor |
T19638 | 10696-10699 | Protein | denotes | TNF |
T19637 | 10558-10600 | Protein | denotes | single-immunoglobulinIL-1 receptor-related |
T19636 | 10550-10556 | Protein | denotes | SIGIRR |
T19635 | 10518-10548 | Protein | denotes | receptor interacting protein 1 |
T19634 | 10512-10516 | Protein | denotes | RIP1 |
T19633 | 10483-10510 | Protein | denotes | receptor activator of NF-κB |
T19632 | 10477-10481 | Protein | denotes | RANK |
T19631 | 10430-10455 | Protein | denotes | NF-κB essential modulator |
T19630 | 10424-10428 | Protein | denotes | NEMO |
T19629 | 10374-10422 | Protein | denotes | myeloid differentiation primary response gene 88 |
T19628 | 10367-10372 | Protein | denotes | MyD88 |
T19627 | 10277-10292 | Protein | denotes | cylindromatosis |
T19626 | 10271-10275 | Protein | denotes | CYLD |
T19625 | 10200-10230 | Protein | denotes | A20-binding inhibitor of NF-κB |
T19624 | 10194-10198 | Protein | denotes | ABIN |
T19623 | 10031-10036 | Protein | denotes | TRAF6 |
T19622 | 10021-10026 | Protein | denotes | IRAK1 |
T19621 | 10001-10005 | Protein | denotes | TLR4 |
T19620 | 9953-9959 | Protein | denotes | SIGIRR |
T19619 | 9871-9876 | Protein | denotes | TRAF6 |
T19618 | 9861-9866 | Protein | denotes | IRAK1 |
T19617 | 9771-9774 | Protein | denotes | p62 |
T19616 | 9760-9766 | Protein | denotes | ABIN-1 |
T19615 | 9667-9672 | Protein | denotes | TRAF6 |
T19614 | 9658-9662 | Protein | denotes | RIP1 |
T19613 | 9542-9546 | Protein | denotes | CYLD |
T19612 | 9534-9537 | Protein | denotes | A20 |
T19611 | 9400-9405 | Protein | denotes | TRAF1 |
T19610 | 9329-9332 | Protein | denotes | p50 |
T19609 | 9321-9324 | Protein | denotes | p65 |
T19608 | 9195-9199 | Protein | denotes | IκBα |
T19607 | 9160-9164 | Protein | denotes | IKK2 |
T19606 | 9121-9125 | Protein | denotes | TAK1 |
T19605 | 9115-9119 | Protein | denotes | TAK1 |
T19604 | 9106-9110 | Protein | denotes | IKK2 |
T19603 | 9023-9027 | Protein | denotes | NEMO |
T19602 | 8999-9004 | Protein | denotes | IRAK1 |
T19601 | 8990-8994 | Protein | denotes | RIP1 |
T19600 | 8926-8931 | Protein | denotes | cIAP2 |
T19599 | 8919-8924 | Protein | denotes | cIAP1 |
T19598 | 8912-8917 | Protein | denotes | TRAF6 |
T19597 | 8905-8910 | Protein | denotes | TRAF2 |
T19596 | 8874-8879 | Protein | denotes | IRAK4 |
T19595 | 8867-8872 | Protein | denotes | IRAK1 |
T19594 | 8861-8865 | Protein | denotes | RIP1 |
T19593 | 8844-8848 | Protein | denotes | TRIF |
T19592 | 8799-8842 | Protein | denotes | TIR domain-containing adaptor-inducing IFNβ |
T19591 | 8794-8797 | Protein | denotes | MAL |
T19590 | 8787-8792 | Protein | denotes | MyD88 |
T19589 | 8779-8784 | Protein | denotes | TRADD |
T19588 | 8731-8777 | Protein | denotes | TNF receptor 1-associated death domain protein |
T19587 | 8672-8676 | Protein | denotes | TLR4 |
T19586 | 8662-8666 | Protein | denotes | RANK |
T19585 | 8656-8660 | Protein | denotes | CD40 |
T19584 | 8649-8654 | Protein | denotes | TNFR1 |
T17520 | 30853-30858 | Protein | denotes | TRAF6 |
T17519 | 30843-30848 | Protein | denotes | IRAK1 |
T17518 | 30771-30779 | Protein | denotes | miR-146a |
T17517 | 30736-30739 | Protein | denotes | TNF |
T17516 | 30729-30734 | Protein | denotes | IL-1β |
T17515 | 30590-30597 | Protein | denotes | miR-155 |
T17514 | 30584-30585 | Protein | denotes | b |
T17513 | 30575-30583 | Protein | denotes | miR-146a |
T17542 | 32659-32666 | Protein | denotes | miR-223 |
T17541 | 32646-32653 | Protein | denotes | miR-132 |
T17540 | 32638-32644 | Protein | denotes | miR-16 |
T17539 | 32575-32579 | Protein | denotes | IL-6 |
T17538 | 32544-32570 | Protein | denotes | matrix metalloproteinase-1 |
T17537 | 32500-32507 | Protein | denotes | miR-203 |
T17536 | 32368-32402 | Protein | denotes | monocyte chemoattractant protein 1 |
T17535 | 32324-32332 | Protein | denotes | miR-124a |
T17534 | 32152-32159 | Protein | denotes | miR-155 |
T17533 | 31754-31761 | Protein | denotes | miR-155 |
T17532 | 31680-31683 | Protein | denotes | TNF |
T17531 | 31651-31658 | Protein | denotes | miR-155 |
T17530 | 31450-31457 | Protein | denotes | miR-155 |
T17529 | 31364-31372 | Protein | denotes | miR-146a |
T17528 | 31263-31268 | Protein | denotes | IL-17 |
T17527 | 31254-31257 | Protein | denotes | CD4 |
T17526 | 31220-31228 | Protein | denotes | miR-146a |
T17525 | 31055-31062 | Protein | denotes | miR-155 |
T17524 | 31015-31019 | Protein | denotes | RIP1 |
T17523 | 31006-31010 | Protein | denotes | IKKε |
T17522 | 30931-30938 | Protein | denotes | miR-155 |
T17521 | 30894-30902 | Protein | denotes | miR-146a |
T16429 | 30190-30195 | Protein | denotes | TRAF1 |
T16428 | 30057-30062 | Protein | denotes | TRAF1 |
T16427 | 29955-29960 | Protein | denotes | TRAF1 |
T16426 | 29728-29731 | Protein | denotes | A20 |
T16425 | 29708-29713 | Protein | denotes | TRAF1 |
T16424 | 29595-29600 | Protein | denotes | TRAF1 |
T16423 | 29528-29533 | Protein | denotes | TRAF1 |
T16422 | 29426-29431 | Protein | denotes | TRAF2 |
T16421 | 29330-29335 | Protein | denotes | TRAF1 |
T16420 | 29299-29303 | Protein | denotes | CD40 |
T16419 | 29251-29256 | Protein | denotes | TRAF1 |
T16418 | 29170-29173 | Protein | denotes | TNF |
T16417 | 29122-29127 | Protein | denotes | TRAF1 |
T16416 | 29092-29095 | Protein | denotes | TNF |
T16415 | 29077-29082 | Protein | denotes | TRAF1 |
T16414 | 29051-29054 | Protein | denotes | TNF |
T16413 | 29029-29034 | Protein | denotes | TRAF1 |
T16412 | 28862-28867 | Protein | denotes | TRAF1 |
T16411 | 28798-28807 | Protein | denotes | ubiquitin |
T16410 | 28688-28693 | Protein | denotes | TRAF1 |
T16409 | 28655-28687 | Protein | denotes | TNF receptor-associated factor 1 |
T15546 | 28594-28600 | Protein | denotes | SIGIRR |
T15545 | 28510-28516 | Protein | denotes | SIGIRR |
T15544 | 28405-28411 | Protein | denotes | SIGIRR |
T15543 | 28212-28218 | Protein | denotes | SIGIRR |
T15542 | 28168-28174 | Protein | denotes | SIGIRR |
T15541 | 28019-28025 | Protein | denotes | SIGIRR |
T15540 | 27843-27849 | Protein | denotes | SIGIRR |
T15539 | 27813-27819 | Protein | denotes | SIGIRR |
T15538 | 27717-27722 | Protein | denotes | IL-1R |
T15537 | 27666-27671 | Protein | denotes | TRAF6 |
T15536 | 27657-27662 | Protein | denotes | IRAK1 |
T15535 | 27650-27655 | Protein | denotes | MyD88 |
T15534 | 27566-27571 | Protein | denotes | IL-1R |
T15533 | 27464-27469 | Protein | denotes | TIR-8 |
T15532 | 27433-27439 | Protein | denotes | SIGIRR |
T15531 | 27388-27431 | Protein | denotes | Single-immunoglobulin IL-1 receptor-related |
T14243 | 27244-27248 | Protein | denotes | CYLD |
T14242 | 27135-27139 | Protein | denotes | RANK |
T14241 | 27106-27110 | Protein | denotes | CYLD |
T14240 | 26993-26996 | Protein | denotes | p62 |
T14239 | 26896-26901 | Protein | denotes | TRAF6 |
T14238 | 26862-26866 | Protein | denotes | CYLD |
T14237 | 26824-26838 | Protein | denotes | sequestosome 1 |
T14236 | 26805-26808 | Protein | denotes | p62 |
T14235 | 26771-26780 | Protein | denotes | ubiquitin |
T14234 | 26757-26762 | Protein | denotes | TRAF6 |
T14233 | 26690-26695 | Protein | denotes | RANKL |
T14232 | 26630-26634 | Protein | denotes | CYLD |
T14231 | 26559-26564 | Protein | denotes | RANKL |
T14230 | 26420-26424 | Protein | denotes | CYLD |
T14229 | 26333-26337 | Protein | denotes | RANK |
T14228 | 26290-26294 | Protein | denotes | CYLD |
T14227 | 26143-26147 | Protein | denotes | CYLD |
T14226 | 25985-25988 | Protein | denotes | A20 |
T14225 | 25948-25952 | Protein | denotes | CYLD |
T14224 | 25933-25936 | Protein | denotes | A20 |
T14223 | 25884-25887 | Protein | denotes | A20 |
T14222 | 25843-25847 | Protein | denotes | TAK1 |
T14221 | 25834-25838 | Protein | denotes | RIP1 |
T14220 | 25827-25832 | Protein | denotes | TRAF7 |
T14219 | 25820-25825 | Protein | denotes | TRAF6 |
T14218 | 25813-25818 | Protein | denotes | TRAF2 |
T14217 | 25807-25811 | Protein | denotes | NEMO |
T14216 | 25674-25678 | Protein | denotes | RANK |
T14215 | 25588-25611 | Protein | denotes | deubiquitinating enzyme |
T14214 | 25578-25582 | Protein | denotes | CYLD |
T14213 | 25385-25389 | Protein | denotes | CYLD |
T14212 | 25279-25283 | Protein | denotes | CYLD |
T14211 | 25262-25277 | Protein | denotes | Cylindromatosis |
T14210 | 25238-25253 | Protein | denotes | Cylindromatosis |
T12736 | 24679-24685 | Protein | denotes | ABIN-1 |
T12735 | 24537-24540 | Protein | denotes | A20 |
T12734 | 24526-24532 | Protein | denotes | ABIN-3 |
T12733 | 24239-24242 | Protein | denotes | A20 |
T12732 | 24217-24223 | Protein | denotes | ABIN-1 |
T12731 | 24136-24142 | Protein | denotes | ABIN-1 |
T12730 | 24076-24079 | Protein | denotes | TNF |
T12729 | 24048-24054 | Protein | denotes | ABIN-1 |
T12728 | 23962-23965 | Protein | denotes | TNF |
T12727 | 23915-23921 | Protein | denotes | ABIN-1 |
T12726 | 23883-23886 | Protein | denotes | TNF |
T12725 | 23853-23859 | Protein | denotes | ABIN-1 |
T12724 | 23848-23851 | Protein | denotes | A20 |
T12723 | 23762-23789 | Protein | denotes | truncated and inactive form |
T12722 | 23707-23713 | Protein | denotes | ABIN-3 |
T12721 | 23516-23522 | Protein | denotes | ABIN-2 |
T12720 | 23495-23501 | Protein | denotes | ABIN-1 |
T12719 | 23383-23386 | Protein | denotes | A20 |
T12718 | 23308-23314 | Protein | denotes | ABIN-3 |
T12717 | 23297-23303 | Protein | denotes | ABIN-1 |
T12716 | 23292-23295 | Protein | denotes | A20 |
T12715 | 23236-23239 | Protein | denotes | A20 |
T12714 | 23080-23083 | Protein | denotes | TNF |
T12713 | 23009-23012 | Protein | denotes | A20 |
T12712 | 22959-22965 | Protein | denotes | TNIP-3 |
T12711 | 22947-22953 | Protein | denotes | TNIP-2 |
T12710 | 22939-22945 | Protein | denotes | TNIP-1 |
T12709 | 22917-22923 | Protein | denotes | ABIN-3 |
T12708 | 22906-22912 | Protein | denotes | ABIN-2 |
T12707 | 22898-22904 | Protein | denotes | ABIN-1 |
T12706 | 22866-22869 | Protein | denotes | A20 |
T9786 | 19643-19646 | Protein | denotes | TNF |
T9785 | 19483-19486 | Protein | denotes | A20 |
T9784 | 19360-19363 | Protein | denotes | TNF |
T9783 | 19311-19314 | Protein | denotes | A20 |
T9782 | 19126-19129 | Protein | denotes | A20 |
T9781 | 19062-19065 | Protein | denotes | A20 |
T9780 | 18964-18967 | Protein | denotes | A20 |
T9779 | 18882-18904 | Protein | denotes | Tax1-binding protein 1 |
T9778 | 18838-18877 | Protein | denotes | A20-binding inhibitor of NF-κB (ABIN) 1 |
T9777 | 18753-18756 | Protein | denotes | A20 |
T9776 | 18691-18694 | Protein | denotes | A20 |
T9775 | 18634-18635 | Protein | denotes | 2 |
T9774 | 18628-18633 | Protein | denotes | cIAP1 |
T9773 | 18618-18623 | Protein | denotes | TRAF2 |
T9772 | 18611-18616 | Protein | denotes | TRAF6 |
T9771 | 18577-18583 | Protein | denotes | Ubc5hc |
T9770 | 18567-18572 | Protein | denotes | Ubc13 |
T9769 | 18404-18409 | Protein | denotes | MALT1 |
T9768 | 18394-18399 | Protein | denotes | TRAF6 |
T9767 | 18388-18392 | Protein | denotes | RIP2 |
T9766 | 18382-18386 | Protein | denotes | RIP1 |
T9765 | 18275-18278 | Protein | denotes | A20 |
T9764 | 18132-18135 | Protein | denotes | TNF |
T9763 | 18038-18043 | Protein | denotes | NF-κB |
T9762 | 17986-18011 | Protein | denotes | ubiquitin-editing protein |
T9761 | 17972-17979 | Protein | denotes | TNFAIP3 |
T9760 | 17953-17956 | Protein | denotes | A20 |
T9759 | 17941-17944 | Protein | denotes | A20 |
T9820 | 22791-22794 | Protein | denotes | A20 |
T9819 | 22555-22558 | Protein | denotes | A20 |
T9818 | 22507-22510 | Protein | denotes | A20 |
T9817 | 22327-22330 | Protein | denotes | A20 |
T9816 | 22246-22249 | Protein | denotes | A20 |
T9815 | 22208-22216 | Protein | denotes | cytokine |
T9814 | 22176-22179 | Protein | denotes | TNF |
T9813 | 22151-22154 | Protein | denotes | TNF |
T9812 | 22116-22119 | Protein | denotes | A20 |
T9811 | 22029-22032 | Protein | denotes | A20 |
T9810 | 21982-21985 | Protein | denotes | A20 |
T9809 | 21828-21831 | Protein | denotes | A20 |
T9808 | 21607-21610 | Protein | denotes | A20 |
T9807 | 21461-21464 | Protein | denotes | A20 |
T9806 | 21257-21260 | Protein | denotes | A20 |
T9805 | 21162-21165 | Protein | denotes | A20 |
T9804 | 21013-21016 | Protein | denotes | A20 |
T9803 | 21004-21009 | Protein | denotes | IL-1β |
T9802 | 20996-20999 | Protein | denotes | TNF |
T9801 | 20869-20874 | Protein | denotes | IL-1β |
T9800 | 20861-20864 | Protein | denotes | TNF |
T9799 | 20703-20706 | Protein | denotes | A20 |
T9798 | 20639-20674 | Protein | denotes | monocyte chemo-attractant protein 1 |
T9797 | 20632-20637 | Protein | denotes | RANKL |
T9796 | 20618-20622 | Protein | denotes | IL-6 |
T9795 | 20611-20616 | Protein | denotes | IL-1β |
T9794 | 20606-20609 | Protein | denotes | TNF |
T9793 | 20499-20502 | Protein | denotes | A20 |
T9792 | 20271-20274 | Protein | denotes | A20 |
T9791 | 20168-20171 | Protein | denotes | A20 |
T9790 | 20106-20109 | Protein | denotes | A20 |
T9789 | 19929-19932 | Protein | denotes | A20 |
T9788 | 19798-19801 | Protein | denotes | A20 |
T9787 | 19677-19680 | Protein | denotes | A20 |
T4563 | 15489-15494 | Protein | denotes | TRAF2 |
T4562 | 15440-15445 | Protein | denotes | TRAF6 |
T4561 | 15429-15434 | Protein | denotes | TRAF5 |
T4560 | 15422-15427 | Protein | denotes | TRAF3 |
T4559 | 15415-15420 | Protein | denotes | TRAF2 |
T4558 | 15408-15413 | Protein | denotes | TRAF1 |
T4557 | 15357-15361 | Protein | denotes | RANK |
T4556 | 15348-15352 | Protein | denotes | CD40 |
T4555 | 15228-15232 | Protein | denotes | RANK |
T4554 | 15201-15223 | Protein | denotes | lymphotoxin β receptor |
T4553 | 15195-15199 | Protein | denotes | CD40 |
T4552 | 13798-13802 | Protein | denotes | IKK1 |
T4551 | 13777-13780 | Protein | denotes | NIK |
T4550 | 13725-13728 | Protein | denotes | NIK |
T4549 | 13672-13677 | Protein | denotes | TRAF3 |
T4548 | 13634-13635 | Protein | denotes | 2 |
T4547 | 13628-13633 | Protein | denotes | cIAP1 |
T4546 | 13618-13623 | Protein | denotes | TRAF2 |
T4545 | 13540-13545 | Protein | denotes | TRAF3 |
T4544 | 13426-13429 | Protein | denotes | NIK |
T4543 | 13395-13396 | Protein | denotes | 2 |
T4542 | 13389-13394 | Protein | denotes | cIAP1 |
T4541 | 13378-13383 | Protein | denotes | TRAF3 |
T4540 | 13371-13376 | Protein | denotes | TRAF2 |
T4539 | 13330-13333 | Protein | denotes | NIK |
T4538 | 13185-13188 | Protein | denotes | NIK |
T4537 | 13179-13182 | Protein | denotes | NIK |
T4536 | 13156-13177 | Protein | denotes | NF-κB inducing kinase |
T4535 | 13107-13111 | Protein | denotes | IKK1 |
T4534 | 12892-12896 | Protein | denotes | RelB |
T4533 | 12863-12866 | Protein | denotes | p52 |
T4532 | 12824-12828 | Protein | denotes | p100 |
T4531 | 12790-12794 | Protein | denotes | RANK |
T4530 | 12780-12784 | Protein | denotes | CD40 |
T4529 | 12765-12778 | Protein | denotes | BAFF receptor |
T4528 | 12741-12763 | Protein | denotes | lymphotoxin β receptor |
T4527 | 12662-12665 | Protein | denotes | TNF |
T4526 | 12597-12601 | Protein | denotes | TAK1 |
T4525 | 12533-12537 | Protein | denotes | RIP1 |
T4524 | 12518-12523 | Protein | denotes | TRAF6 |
T4523 | 12499-12503 | Protein | denotes | TRIF |
T4522 | 12487-12492 | Protein | denotes | TRAF6 |
T4521 | 12427-12432 | Protein | denotes | TRAF6 |
T4520 | 12347-12352 | Protein | denotes | MyD88 |
T4519 | 12326-12330 | Protein | denotes | TRIF |
T4518 | 12281-12324 | Protein | denotes | TIR domain-containing adaptor-inducing IFNβ |
T4517 | 12270-12275 | Protein | denotes | MyD88 |
T4516 | 12220-12268 | Protein | denotes | myeloid differentiation primary response gene 88 |
T4515 | 12156-12160 | Protein | denotes | TRAM |
T4514 | 12125-12154 | Protein | denotes | TRIF-related adaptor molecule |
T4513 | 12116-12118 | Protein | denotes | Ma |
T4512 | 12060-12094 | Protein | denotes | Toll/IL-1 receptor adaptor protein |
T4511 | 11994-11998 | Protein | denotes | TLR4 |
T4510 | 11906-11910 | Protein | denotes | TAK1 |
T4509 | 11680-11683 | Protein | denotes | TNF |
T4508 | 11621-11625 | Protein | denotes | NEMO |
T4507 | 11529-11530 | Protein | denotes | 2 |
T4506 | 11524-11528 | Protein | denotes | TAB1 |
T4505 | 11515-11519 | Protein | denotes | NEMO |
T4504 | 11467-11471 | Protein | denotes | TAK1 |
T4503 | 11405-11409 | Protein | denotes | RIP1 |
T4502 | 11308-11312 | Protein | denotes | RIP1 |
T4501 | 11282-11283 | Protein | denotes | 2 |
T4500 | 11276-11281 | Protein | denotes | cIAP1 |
T4499 | 11270-11271 | Protein | denotes | 5 |
T4498 | 11264-11269 | Protein | denotes | TRAF2 |
T4497 | 11203-11207 | Protein | denotes | RIP1 |
T4496 | 11167-11170 | Protein | denotes | TNF |
T4495 | 11146-11151 | Protein | denotes | cIAP2 |
T4494 | 11101-11141 | Protein | denotes | cellular inhibitor of apoptosis (cIAP) 1 |
T4493 | 11050-11055 | Protein | denotes | TRAF5 |
T4492 | 11006-11045 | Protein | denotes | TNF receptor-associated factor (TRAF) 2 |
T4491 | 10935-10939 | Protein | denotes | RIP1 |
T4490 | 10903-10933 | Protein | denotes | receptor interacting protein 1 |
T4489 | 10881-10886 | Protein | denotes | TRADD |
T4488 | 10841-10879 | Protein | denotes | TNF receptor-1-associated death domain |
T4487 | 10795-10798 | Protein | denotes | TNF |
T4486 | 10782-10785 | Protein | denotes | TNF |
T4485 | 8474-8478 | Protein | denotes | IKK1 |
T4484 | 8460-8464 | Protein | denotes | NEMO |
T4483 | 8451-8455 | Protein | denotes | IKK2 |
T4482 | 8394-8398 | Protein | denotes | IKKγ |
T4481 | 8373-8377 | Protein | denotes | NEMO |
T4480 | 8346-8371 | Protein | denotes | NF-κB essential modulator |
T4479 | 8313-8317 | Protein | denotes | IKKβ |
T4478 | 8304-8308 | Protein | denotes | IKKα |
T4477 | 8284-8288 | Protein | denotes | IKK2 |
T4476 | 8275-8279 | Protein | denotes | IKK1 |
T4475 | 7830-7835 | Protein | denotes | RANKL |
T4474 | 7808-7811 | Protein | denotes | TNF |
T4473 | 7481-7484 | Protein | denotes | p50 |
T4472 | 7473-7476 | Protein | denotes | p52 |
T4471 | 7446-7450 | Protein | denotes | p105 |
T4470 | 7437-7441 | Protein | denotes | p100 |
T4469 | 7374-7379 | Protein | denotes | Bcl-3 |
T4468 | 7365-7369 | Protein | denotes | IκBξ |
T4467 | 7326-7332 | Protein | denotes | NF-κB2 |
T4466 | 7306-7310 | Protein | denotes | p100 |
T4465 | 7297-7303 | Protein | denotes | NF-κB1 |
T4464 | 7277-7281 | Protein | denotes | p105 |
T4463 | 7271-7275 | Protein | denotes | IκBε |
T4462 | 7265-7269 | Protein | denotes | IκBβ |
T4461 | 7259-7263 | Protein | denotes | IκBα |
T1846 | 6759-6769 | Protein | denotes | tenascin C |
T1845 | 6749-6757 | Protein | denotes | biglycan |
T1844 | 6736-6747 | Protein | denotes | fibronectin |
T1843 | 6565-6569 | Protein | denotes | TLR4 |
T1842 | 6341-6367 | Protein | denotes | myeloid-related protein 14 |
T1841 | 6311-6336 | Protein | denotes | Myeloid-related protein 8 |
T1840 | 6248-6253 | Protein | denotes | HMGB1 |
T1839 | 6183-6188 | Protein | denotes | HMGB1 |
T1838 | 6138-6143 | Protein | denotes | HMGB1 |
T1837 | 6099-6111 | Protein | denotes | TLR4 ligands |
T1836 | 5954-5973 | Protein | denotes | chromatin component |
T1835 | 5927-5932 | Protein | denotes | HMGB1 |
T1834 | 5880-5925 | Protein | denotes | High mobility group box chromosomal protein 1 |
T1833 | 5011-5033 | Protein | denotes | lymphotoxin β receptor |
T1832 | 4957-4961 | Protein | denotes | BAFF |
T1831 | 4836-4840 | Protein | denotes | BAFF |
T1830 | 4810-4834 | Protein | denotes | B-cell activating factor |
T1829 | 4576-4580 | Protein | denotes | CD40 |
T1828 | 4302-4305 | Protein | denotes | CD4 |
T1827 | 4235-4240 | Protein | denotes | CD154 |
T1826 | 4222-4233 | Protein | denotes | CD40 ligand |
T1825 | 4197-4200 | Protein | denotes | TNF |
T1824 | 3919-3945 | Protein | denotes | TNF receptor family member |
T1823 | 3903-3907 | Protein | denotes | CD40 |
T1822 | 3789-3793 | Protein | denotes | RANK |
T1821 | 3693-3697 | Protein | denotes | RANK |
T1820 | 3664-3691 | Protein | denotes | receptor activator of NF-κB |
T1819 | 3450-3453 | Protein | denotes | TNF |
T1818 | 3375-3378 | Protein | denotes | TNF |
T1817 | 3316-3319 | Protein | denotes | TNF |
T373 | 2966-2971 | Protein | denotes | c-REL |
T372 | 2953-2960 | Protein | denotes | TNFAIP3 |
T371 | 2946-2951 | Protein | denotes | TRAF1 |
T370 | 2940-2944 | Protein | denotes | CD40 |
T369 | 2690-2695 | Protein | denotes | RANKL |
T368 | 2654-2688 | Protein | denotes | receptor activator of NF-κB ligand |
T367 | 2035-2038 | Protein | denotes | TNF |
T366 | 1932-1963 | Protein | denotes | inducible nitric oxide synthase |
T365 | 1901-1918 | Protein | denotes | cyclo-oxygenase-2 |
T364 | 1895-1899 | Protein | denotes | IL-6 |
T363 | 1884-1887 | Protein | denotes | TNF |
T362 | 1758-1763 | Protein | denotes | c-Rel |
T361 | 1752-1756 | Protein | denotes | RelB |
T360 | 1746-1750 | Protein | denotes | RelA |
T359 | 1739-1742 | Protein | denotes | p65 |
T358 | 1731-1737 | Protein | denotes | NF-κB1 |
T357 | 1723-1727 | Protein | denotes | p105 |
T356 | 1715-1721 | Protein | denotes | NF-κB2 |
T355 | 1707-1711 | Protein | denotes | p100 |
T4566 | 15725-15730 | Protein | denotes | TRAF6 |
T4565 | 15676-15680 | Protein | denotes | CD40 |
T4564 | 15499-15504 | Protein | denotes | TRAF3 |
T15530 | 27336-27379 | Protein | denotes | Single-immunoglobulin IL-1 receptor-related |
T8425 | 17781-17785 | Protein | denotes | IKK1 |
T8424 | 17680-17683 | Protein | denotes | NIK |
T8423 | 17660-17664 | Protein | denotes | IKK1 |
T8422 | 17596-17601 | Protein | denotes | STAT1 |
T8421 | 17480-17484 | Protein | denotes | IKK1 |
T8420 | 17457-17461 | Protein | denotes | IκBα |
T8419 | 17437-17441 | Protein | denotes | IKK2 |
T8418 | 17353-17357 | Protein | denotes | IKK1 |
T8417 | 17297-17301 | Protein | denotes | IKK1 |
T8416 | 17069-17073 | Protein | denotes | IKK1 |
T8415 | 16915-16921 | Protein | denotes | TOLLIP |
T8414 | 16903-16909 | Protein | denotes | IRAK-M |
T8413 | 16895-16901 | Protein | denotes | MyD88s |
T4571 | 15890-15894 | Protein | denotes | CD40 |
T4570 | 15850-15855 | Protein | denotes | TRAF3 |
T4569 | 15803-15808 | Protein | denotes | TRAF2 |
T4568 | 15780-15784 | Protein | denotes | IL-6 |
T4567 | 15747-15751 | Protein | denotes | CD40 |
bionlp-st-ge-2016-coref
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T21497 | 14649-14664 | Antecedent | denotes | phosphorylation |
T21496 | 14666-14670 | Anaphor | denotes | This |
T21495 | 14617-14621 | Antecedent | denotes | IKK1 |
T21494 | 14623-14628 | Anaphor | denotes | which |
T21493 | 14354-14355 | Antecedent | denotes | 2 |
T21492 | 14348-14353 | Antecedent | denotes | cIAP1 |
T21491 | 14370-14375 | Anaphor | denotes | their |
T21490 | 14092-14097 | Antecedent | denotes | TRAF3 |
T21489 | 14085-14090 | Antecedent | denotes | TRAF2 |
T21488 | 14111-14116 | Anaphor | denotes | which |
T19583 | 9953-9959 | Antecedent | denotes | SIGIRR |
T19582 | 9961-9966 | Anaphor | denotes | which |
T19581 | 9771-9774 | Antecedent | denotes | p62 |
T19580 | 9760-9766 | Antecedent | denotes | ABIN-1 |
T19579 | 9735-9751 | Anaphor | denotes | adaptor proteins |
T19578 | 9542-9546 | Antecedent | denotes | CYLD |
T19577 | 9534-9537 | Antecedent | denotes | A20 |
T19576 | 9683-9687 | Anaphor | denotes | they |
T19575 | 9195-9199 | Antecedent | denotes | IκBα |
T19574 | 9212-9215 | Anaphor | denotes | its |
T19573 | 8672-8676 | Antecedent | denotes | TLR4 |
T19572 | 8662-8666 | Antecedent | denotes | RANK |
T19571 | 8656-8660 | Antecedent | denotes | CD40 |
T19570 | 8649-8654 | Antecedent | denotes | TNFR1 |
T19569 | 8622-8640 | Anaphor | denotes | membrane receptors |
T17512 | 31754-31761 | Antecedent | denotes | miR-155 |
T17511 | 31918-31923 | Anaphor | denotes | their |
T17510 | 30590-30597 | Antecedent | denotes | miR-155 |
T17509 | 30669-30681 | Anaphor | denotes | these miRNAs |
T16408 | 29708-29713 | Antecedent | denotes | TRAF1 |
T16407 | 29743-29745 | Anaphor | denotes | it |
T15529 | 28594-28600 | Antecedent | denotes | SIGIRR |
T15528 | 28559-28562 | Anaphor | denotes | its |
T15527 | 28405-28411 | Antecedent | denotes | SIGIRR |
T15526 | 28432-28435 | Anaphor | denotes | its |
T15525 | 27566-27571 | Antecedent | denotes | IL-1R |
T15524 | 27633-27648 | Anaphor | denotes | these receptors |
T15523 | 27464-27469 | Antecedent | denotes | TIR-8 |
T15522 | 27507-27511 | Anaphor | denotes | that |
T14209 | 25843-25847 | Antecedent | denotes | TAK1 |
T14208 | 25834-25838 | Antecedent | denotes | RIP1 |
T14207 | 25827-25832 | Antecedent | denotes | TRAF7 |
T14206 | 25820-25825 | Antecedent | denotes | TRAF6 |
T14205 | 25813-25818 | Antecedent | denotes | TRAF2 |
T14204 | 25807-25811 | Antecedent | denotes | NEMO |
T14203 | 25857-25862 | Anaphor | denotes | these |
T16406 | 29728-29731 | Antecedent | denotes | A20 |
T16405 | 29737-29742 | Anaphor | denotes | which |
T1811 | 3946-3950 | Anaphor | denotes | that |
T1816 | 5954-5973 | Antecedent | denotes | chromatin component |
T1815 | 5974-5978 | Anaphor | denotes | that |
T1814 | 4222-4233 | Antecedent | denotes | CD40 ligand |
T1813 | 4243-4248 | Anaphor | denotes | which |
T1812 | 3903-3907 | Antecedent | denotes | CD40 |
T4460 | 13725-13728 | Antecedent | denotes | NIK |
T4459 | 13734-13737 | Anaphor | denotes | its |
T4458 | 13540-13545 | Antecedent | denotes | TRAF3 |
T4457 | 13578-13580 | Anaphor | denotes | it |
T4456 | 13426-13429 | Antecedent | denotes | NIK |
T4455 | 13442-13445 | Anaphor | denotes | its |
T4454 | 13107-13111 | Antecedent | denotes | IKK1 |
T4453 | 13113-13118 | Anaphor | denotes | which |
T4452 | 11050-11055 | Antecedent | denotes | TRAF5 |
T4451 | 11006-11045 | Antecedent | denotes | TNF receptor-associated factor (TRAF) 2 |
T4450 | 11057-11062 | Anaphor | denotes | which |
T4449 | 10903-10933 | Antecedent | denotes | receptor interacting protein 1 |
T4448 | 10841-10879 | Antecedent | denotes | TNF receptor-1-associated death domain |
T4447 | 10942-10947 | Anaphor | denotes | which |
R3025 | T4447 | T4448 | boundBy | which,TNF receptor-1-associated death domain |
R3026 | T4447 | T4449 | boundBy | which,receptor interacting protein 1 |
R3027 | T4450 | T4451 | boundBy | which,TNF receptor-associated factor (TRAF) 2 |
R3028 | T4450 | T4452 | boundBy | which,TRAF5 |
R3029 | T4453 | T4454 | boundBy | which,IKK1 |
R3030 | T4455 | T4456 | boundBy | its,NIK |
R3031 | T4457 | T4458 | boundBy | it,TRAF3 |
R3032 | T4459 | T4460 | boundBy | its,NIK |
R9341 | T14203 | T14204 | boundBy | these,NEMO |
R9342 | T14203 | T14205 | boundBy | these,TRAF2 |
R9343 | T14203 | T14206 | boundBy | these,TRAF6 |
R9344 | T14203 | T14207 | boundBy | these,TRAF7 |
R9345 | T14203 | T14208 | boundBy | these,RIP1 |
R9346 | T14203 | T14209 | boundBy | these,TAK1 |
R10198 | T15522 | T15523 | boundBy | that,TIR-8 |
R10199 | T15524 | T15525 | boundBy | these receptors,IL-1R |
R10200 | T15526 | T15527 | boundBy | its,SIGIRR |
R10201 | T15528 | T15529 | boundBy | its,SIGIRR |
R12918 | T19569 | T19570 | boundBy | membrane receptors,TNFR1 |
R12919 | T19569 | T19571 | boundBy | membrane receptors,CD40 |
R12920 | T19569 | T19572 | boundBy | membrane receptors,RANK |
R12921 | T19569 | T19573 | boundBy | membrane receptors,TLR4 |
R12922 | T19574 | T19575 | boundBy | its,IκBα |
R12923 | T19576 | T19577 | boundBy | they,A20 |
R12924 | T19576 | T19578 | boundBy | they,CYLD |
R12925 | T19579 | T19580 | boundBy | adaptor proteins,ABIN-1 |
R12926 | T19579 | T19581 | boundBy | adaptor proteins,p62 |
R12927 | T19582 | T19583 | boundBy | which,SIGIRR |
R14003 | T21488 | T21489 | boundBy | which,TRAF2 |
R14004 | T21488 | T21490 | boundBy | which,TRAF3 |
R14005 | T21491 | T21492 | boundBy | their,cIAP1 |
R14006 | T21491 | T21493 | boundBy | their,2 |
R14007 | T21494 | T21495 | boundBy | which,IKK1 |
R14008 | T21496 | T21497 | boundBy | This,phosphorylation |
R1311 | T1811 | T1812 | boundBy | that,CD40 |
R1312 | T1813 | T1814 | boundBy | which,CD40 ligand |
R1313 | T1815 | T1816 | boundBy | that,chromatin component |
R10778 | T16405 | T16406 | boundBy | which,A20 |
R10779 | T16407 | T16408 | boundBy | it,TRAF1 |
R11438 | T17509 | T17510 | boundBy | these miRNAs,miR-155 |
R11439 | T17511 | T17512 | boundBy | their,miR-155 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
21639951-18267068-4289426 | 1810-1811 | 18267068 | denotes | 1 |
21639951-18982160-4289427 | 2111-2112 | 18982160 | denotes | 3 |
21639951-18853343-4289428 | 2361-2362 | 18853343 | denotes | 4 |
21639951-9892501-4289429 | 2512-2513 | 9892501 | denotes | 5 |
21639951-15899029-4289430 | 2514-2515 | 15899029 | denotes | 6 |
21639951-16356770-4289431 | 2817-2818 | 16356770 | denotes | 7 |
21639951-20192992-4289432 | 3046-3047 | 20192992 | denotes | 8 |
21639951-19798034-4289433 | 3445-3446 | 19798034 | denotes | 9 |
21639951-18982160-4289434 | 3639-3640 | 18982160 | denotes | 3 |
21639951-16356770-4289435 | 3899-3900 | 16356770 | denotes | 7 |
21639951-8973616-4289436 | 4202-4204 | 8973616 | denotes | 10 |
21639951-7689748-4289437 | 4748-4750 | 7689748 | denotes | 11 |
21639951-11083282-4289438 | 4751-4753 | 11083282 | denotes | 12 |
21639951-18771589-4289439 | 4997-4999 | 18771589 | denotes | 13 |
21639951-18771589-4289440 | 5149-5151 | 18771589 | denotes | 13 |
21639951-19772831-4289441 | 5558-5560 | 19772831 | denotes | 14 |
21639951-20629986-4289442 | 5561-5563 | 20629986 | denotes | 15 |
21639951-12847700-4289443 | 6306-6308 | 12847700 | denotes | 16 |
21639951-10728757-4289444 | 6606-6608 | 10728757 | denotes | 17 |
21639951-17767165-4289445 | 6609-6611 | 17767165 | denotes | 18 |
21639951-19772831-4289446 | 6816-6818 | 19772831 | denotes | 14 |
21639951-20629986-4289447 | 6819-6821 | 20629986 | denotes | 15 |
21639951-19302050-4289448 | 7224-7226 | 19302050 | denotes | 19 |
21639951-21135871-4289449 | 8211-8213 | 21135871 | denotes | 20 |
21639951-16470223-4289450 | 8525-8527 | 16470223 | denotes | 21 |
21639951-19136968-4289451 | 11736-11738 | 19136968 | denotes | 22 |
21639951-19675569-4289452 | 11920-11922 | 19675569 | denotes | 23 |
21639951-18438411-4289453 | 12494-12496 | 18438411 | denotes | 24 |
21639951-16306937-4289454 | 12525-12527 | 16306937 | denotes | 25 |
21639951-16115877-4289455 | 12539-12541 | 16115877 | denotes | 26 |
21639951-21173796-4289456 | 13047-13049 | 21173796 | denotes | 27 |
21639951-11520989-4289457 | 13820-13822 | 11520989 | denotes | 28 |
21639951-15140882-4289458 | 13823-13825 | 15140882 | denotes | 29 |
21639951-21041727-4289459 | 15907-15909 | 21041727 | denotes | 30 |
21639951-20348096-4289460 | 15910-15912 | 20348096 | denotes | 31 |
21639951-19233657-4289461 | 16458-16460 | 19233657 | denotes | 32 |
21639951-15928677-4289462 | 16957-16959 | 15928677 | denotes | 33 |
21639951-15858576-4289463 | 17475-17477 | 15858576 | denotes | 34 |
21639951-17540171-4289464 | 17603-17605 | 17540171 | denotes | 35 |
21639951-20501937-4289465 | 17751-17753 | 20501937 | denotes | 36 |
21639951-19008218-4289466 | 18269-18271 | 19008218 | denotes | 37 |
21639951-15258597-4289467 | 18465-18467 | 15258597 | denotes | 38 |
21639951-18342009-4289467 | 18465-18467 | 18342009 | denotes | 38 |
21639951-15334086-4289467 | 18465-18467 | 15334086 | denotes | 38 |
21639951-19494296-4289467 | 18465-18467 | 19494296 | denotes | 38 |
21639951-20185725-4289468 | 18729-18731 | 20185725 | denotes | 42 |
21639951-18239685-4289469 | 18906-18908 | 18239685 | denotes | 43 |
21639951-18212736-4289469 | 18906-18908 | 18212736 | denotes | 43 |
21639951-17703191-4289469 | 18906-18908 | 17703191 | denotes | 43 |
21639951-11009421-4289469 | 18906-18908 | 11009421 | denotes | 43 |
21639951-11009421-4289470 | 19306-19308 | 11009421 | denotes | 46 |
21639951-20530205-4289471 | 19744-19746 | 20530205 | denotes | 47 |
21639951-20705491-4289472 | 19921-19923 | 20705491 | denotes | 48 |
21639951-21088135-4289473 | 19924-19926 | 21088135 | denotes | 49 |
21639951-1381359-4289474 | 20151-20153 | 1381359 | denotes | 50 |
21639951-20506221-4289475 | 20848-20850 | 20506221 | denotes | 51 |
21639951-19643665-4289476 | 21723-21725 | 19643665 | denotes | 52 |
21639951-19643665-4289477 | 21887-21889 | 19643665 | denotes | 52 |
21639951-20822710-4289478 | 22608-22610 | 20822710 | denotes | 53 |
21639951-18239685-4289479 | 23273-23275 | 18239685 | denotes | 43 |
21639951-18212736-4289480 | 23276-23278 | 18212736 | denotes | 44 |
21639951-19464428-4289481 | 23470-23472 | 19464428 | denotes | 54 |
21639951-16633345-4289482 | 23688-23690 | 16633345 | denotes | 55 |
21639951-19060883-4289483 | 23691-23693 | 19060883 | denotes | 56 |
21639951-17088249-4289484 | 23836-23838 | 17088249 | denotes | 57 |
21639951-16025521-4289485 | 23906-23908 | 16025521 | denotes | 58 |
21639951-19060883-4289486 | 24000-24002 | 19060883 | denotes | 56 |
21639951-12965196-4289487 | 24328-24330 | 12965196 | denotes | 59 |
21639951-20362473-4289488 | 24659-24661 | 20362473 | denotes | 60 |
21639951-19169254-4289489 | 24780-24782 | 19169254 | denotes | 61 |
21639951-19838195-4289490 | 24783-24785 | 19838195 | denotes | 62 |
21639951-10835629-4289491 | 25380-25382 | 10835629 | denotes | 63 |
21639951-19373246-4289492 | 25572-25574 | 19373246 | denotes | 64 |
21639951-19373246-4289493 | 25725-25727 | 19373246 | denotes | 64 |
21639951-19373246-4289494 | 26270-26272 | 19373246 | denotes | 64 |
21639951-18382763-4289495 | 26381-26383 | 18382763 | denotes | 65 |
21639951-18382763-4289496 | 26841-26843 | 18382763 | denotes | 65 |
21639951-17187080-4289497 | 27073-27075 | 17187080 | denotes | 66 |
21639951-12925853-4289498 | 27673-27675 | 12925853 | denotes | 67 |
21639951-19835640-4289499 | 27786-27788 | 19835640 | denotes | 68 |
21639951-14715412-4289500 | 28001-28003 | 14715412 | denotes | 69 |
21639951-20506350-4289501 | 28004-28006 | 20506350 | denotes | 70 |
21639951-20506350-4289502 | 28348-28350 | 20506350 | denotes | 70 |
21639951-16622006-4289503 | 29007-29009 | 16622006 | denotes | 71 |
21639951-11672546-4289504 | 29010-29012 | 11672546 | denotes | 72 |
21639951-8692885-4289505 | 29771-29773 | 8692885 | denotes | 73 |
21639951-17804836-4289506 | 30021-30023 | 17804836 | denotes | 74 |
21639951-18648537-4289507 | 30105-30107 | 18648537 | denotes | 75 |
21639951-19714643-4289508 | 30212-30214 | 19714643 | denotes | 76 |
21639951-20098459-4289509 | 30570-30572 | 20098459 | denotes | 77 |
21639951-16885212-4289510 | 30750-30752 | 16885212 | denotes | 78 |
21639951-17242365-4289511 | 30753-30755 | 17242365 | denotes | 79 |
21639951-16885212-4289512 | 30904-30906 | 16885212 | denotes | 78 |
21639951-17242365-4289513 | 31021-31023 | 17242365 | denotes | 79 |
21639951-17911593-4289514 | 31024-31026 | 17911593 | denotes | 80 |
21639951-18383392-4289515 | 31142-31144 | 18383392 | denotes | 81 |
21639951-18438844-4289516 | 31145-31147 | 18438844 | denotes | 82 |
21639951-18759964-4289517 | 31215-31217 | 18759964 | denotes | 83 |
21639951-20459811-4289518 | 31305-31307 | 20459811 | denotes | 84 |
21639951-20870441-4289519 | 31445-31447 | 20870441 | denotes | 86 |
21639951-18383392-4289520 | 31636-31638 | 18383392 | denotes | 81 |
21639951-17463289-4289521 | 31737-31739 | 17463289 | denotes | 87 |
21639951-20470394-4289522 | 32053-32055 | 20470394 | denotes | 88 |
21639951-19404929-4289523 | 32465-32467 | 19404929 | denotes | 89 |
21639951-21279994-4289524 | 32624-32626 | 21279994 | denotes | 90 |
21639951-18759964-4289525 | 32799-32801 | 18759964 | denotes | 83 |
21639951-20470394-4289526 | 32802-32804 | 20470394 | denotes | 88 |
21639951-19931339-4289527 | 32805-32807 | 19931339 | denotes | 91 |
pmc-enju-pas
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T5 | 0-8 | JJ | denotes | Negative |
T6 | 9-19 | NN | denotes | regulation |
T7 | 20-22 | IN | denotes | of |
T8 | 23-28 | NN | denotes | NF-κB |
T9 | 29-32 | CC | denotes | and |
T10 | 33-36 | PRP-DOLLAR- | denotes | its |
T11 | 37-48 | NN | denotes | involvement |
T12 | 49-51 | IN | denotes | in |
T13 | 52-62 | JJ | denotes | rheumatoid |
T14 | 63-72 | NN | denotes | arthritis |
T775 | 3046-3047 | CD | denotes | 8 |
T21741 | 15159-15165 | NN | denotes | factor |
T21740 | 15150-15158 | NN | denotes | necrosis |
T21739 | 15143-15149 | NN | denotes | tumour |
T21738 | 15141-15142 | -COMMA- | denotes | , |
T21737 | 15138-15141 | NN | denotes | TNF |
T21736 | 15136-15137 | -COLON- | denotes | ; |
T21735 | 15130-15136 | NN | denotes | factor |
T21734 | 15110-15129 | JJ | denotes | receptor-associated |
T21733 | 15106-15109 | NN | denotes | TNF |
T21732 | 15104-15105 | -COMMA- | denotes | , |
T21731 | 15100-15104 | NN | denotes | TRAF |
T21730 | 15098-15099 | -COLON- | denotes | ; |
T21729 | 15093-15098 | NN | denotes | NF-κB |
T21728 | 15090-15092 | IN | denotes | of |
T21727 | 15080-15089 | NN | denotes | activator |
T21726 | 15071-15079 | NN | denotes | receptor |
T21725 | 15069-15070 | -COMMA- | denotes | , |
T21724 | 15065-15069 | NN | denotes | RANK |
T21723 | 15063-15064 | -COLON- | denotes | ; |
T21722 | 15057-15063 | NN | denotes | factor |
T21721 | 15049-15056 | JJ | denotes | nuclear |
T21720 | 15047-15048 | -COMMA- | denotes | , |
T21719 | 15045-15047 | NN | denotes | NF |
T21718 | 15043-15044 | -COLON- | denotes | ; |
T21717 | 15037-15043 | NN | denotes | kinase |
T21716 | 15033-15036 | NN | denotes | IκB |
T21715 | 15031-15032 | -COMMA- | denotes | , |
T21714 | 15028-15031 | NN | denotes | IKK |
T21713 | 15026-15027 | -COLON- | denotes | ; |
T21712 | 15017-15026 | NN | denotes | apoptosis |
T21711 | 15014-15016 | IN | denotes | of |
T21710 | 15004-15013 | NN | denotes | inhibitor |
T21709 | 14995-15003 | JJ | denotes | cellular |
T21708 | 14993-14994 | -COMMA- | denotes | , |
T21707 | 14989-14993 | NN | denotes | cIAP |
T21706 | 14980-14988 | NN | denotes | factors. |
T21705 | 14960-14979 | JJ | denotes | receptor-associated |
T21704 | 14956-14959 | NN | denotes | TNF |
T21703 | 14950-14955 | JJ | denotes | other |
T21702 | 14945-14949 | IN | denotes | with |
T21701 | 14935-14944 | VB | denotes | competing |
T21700 | 14932-14934 | IN | denotes | by |
T21699 | 14923-14931 | RB | denotes | probably |
T21698 | 14918-14922 | RB | denotes | most |
T21697 | 14916-14917 | -COMMA- | denotes | , |
T21696 | 14909-14916 | NN | denotes | pathway |
T21695 | 14904-14908 | DT | denotes | this |
T21694 | 14901-14903 | IN | denotes | of |
T21693 | 14891-14900 | NN | denotes | regulator |
T21692 | 14882-14890 | JJ | denotes | negative |
T21691 | 14880-14881 | DT | denotes | a |
T21690 | 14877-14879 | IN | denotes | as |
T21689 | 14866-14876 | VB | denotes | identified |
T21688 | 14861-14865 | VB | denotes | been |
T21687 | 14856-14860 | RB | denotes | also |
T21686 | 14852-14855 | VB | denotes | has |
T21685 | 14846-14851 | NN | denotes | TRAF1 |
T21684 | 14844-14845 | -COMMA- | denotes | , |
T21683 | 14839-14844 | NN | denotes | TRAF3 |
T21682 | 14836-14838 | TO | denotes | to |
T21681 | 14831-14835 | JJ | denotes | Next |
T21680 | 14816-14829 | NN | denotes | transcription |
T21679 | 14807-14815 | VB | denotes | activate |
T21678 | 14804-14806 | TO | denotes | to |
T21677 | 14799-14803 | NN | denotes | RelB |
T21676 | 14794-14798 | IN | denotes | with |
T21675 | 14782-14793 | NN | denotes | heterodimer |
T21674 | 14780-14781 | DT | denotes | a |
T21673 | 14774-14779 | VB | denotes | forms |
T21672 | 14768-14773 | WDT | denotes | which |
T21671 | 14766-14767 | -COMMA- | denotes | , |
T21670 | 14763-14766 | NN | denotes | p52 |
T21669 | 14760-14762 | TO | denotes | to |
T21668 | 14755-14759 | NN | denotes | p100 |
T21667 | 14752-14754 | IN | denotes | of |
T21666 | 14740-14751 | NN | denotes | degradation |
T21665 | 14728-14739 | JJ | denotes | proteasomal |
T21664 | 14720-14727 | JJ | denotes | partial |
T21663 | 14716-14719 | CC | denotes | and |
T21662 | 14697-14715 | NN | denotes | polyubiquitination |
T21661 | 14686-14696 | JJ | denotes | K48-linked |
T21660 | 14683-14685 | IN | denotes | by |
T21659 | 14674-14682 | VB | denotes | followed |
T21658 | 14671-14673 | VB | denotes | is |
T21657 | 14666-14670 | DT | denotes | This |
T21656 | 14649-14664 | NN | denotes | phosphorylation |
T21655 | 14644-14648 | NN | denotes | p100 |
T21654 | 14638-14643 | NN | denotes | NF-κB |
T21653 | 14629-14637 | VB | denotes | mediates |
T21652 | 14623-14628 | WDT | denotes | which |
T21651 | 14621-14622 | -COMMA- | denotes | , |
T21650 | 14617-14621 | NN | denotes | IKK1 |
T21649 | 14607-14616 | VB | denotes | activates |
T21648 | 14603-14606 | CC | denotes | and |
T21647 | 14588-14602 | VB | denotes | phosphorylates |
T21646 | 14583-14587 | RB | denotes | then |
T21645 | 14579-14582 | NN | denotes | NIK |
T21644 | 14573-14577 | NN | denotes | cell |
T21643 | 14569-14572 | DT | denotes | the |
T21642 | 14566-14568 | IN | denotes | in |
T21641 | 14559-14565 | NN | denotes | levels |
T21640 | 14555-14558 | NN | denotes | NIK |
T21639 | 14545-14554 | VB | denotes | increased |
T21638 | 14542-14544 | IN | denotes | in |
T21637 | 14532-14541 | VB | denotes | resulting |
T21636 | 14530-14531 | -COMMA- | denotes | , |
T21635 | 14520-14530 | VB | denotes | stabilised |
T21634 | 14517-14519 | VB | denotes | is |
T21633 | 14513-14516 | NN | denotes | NIK |
T21632 | 14509-14512 | CC | denotes | and |
T21631 | 14500-14508 | VB | denotes | degraded |
T21630 | 14497-14499 | VB | denotes | is |
T21629 | 14491-14496 | NN | denotes | TRAF3 |
T21628 | 14489-14490 | -COMMA- | denotes | , |
T21627 | 14483-14489 | NN | denotes | result |
T21626 | 14481-14482 | DT | denotes | a |
T21625 | 14478-14480 | IN | denotes | As |
T21624 | 14473-14476 | NN | denotes | NIK |
T21623 | 14468-14472 | IN | denotes | than |
T21622 | 14461-14467 | RB | denotes | rather |
T21621 | 14459-14460 | -COMMA- | denotes | , |
T21620 | 14454-14459 | NN | denotes | TRAF3 |
T21619 | 14451-14453 | TO | denotes | to |
T21618 | 14432-14450 | NN | denotes | polyubiquitination |
T21617 | 14421-14431 | JJ | denotes | K48-linked |
T21616 | 14417-14420 | PRP-DOLLAR- | denotes | its |
T21615 | 14409-14416 | VB | denotes | directs |
T21614 | 14401-14408 | NN | denotes | cIAP1/2 |
T21613 | 14388-14400 | RB | denotes | Subsequently |
T21612 | 14376-14386 | NN | denotes | activation |
T21611 | 14370-14375 | PRP-DOLLAR- | denotes | their |
T21610 | 14367-14369 | IN | denotes | in |
T21594 | 14250-14252 | VB | denotes | is |
T21593 | 14244-14249 | NN | denotes | TRAF3 |
T21592 | 14242-14243 | -COMMA- | denotes | , |
T21591 | 14235-14242 | NN | denotes | binding |
T21590 | 14228-14234 | NN | denotes | ligand |
T21589 | 14223-14227 | IN | denotes | Upon |
T21588 | 14218-14221 | JJ | denotes | low |
T21587 | 14211-14217 | NN | denotes | levels |
T21586 | 14207-14210 | NN | denotes | NIK |
T21585 | 14199-14206 | VB | denotes | keeping |
T21584 | 14197-14198 | -COMMA- | denotes | , |
T21583 | 14194-14197 | NN | denotes | NIK |
T21582 | 14191-14193 | IN | denotes | of |
T21581 | 14179-14190 | NN | denotes | degradation |
T21580 | 14167-14178 | JJ | denotes | proteasomal |
T21579 | 14163-14166 | CC | denotes | and |
T21578 | 14144-14162 | NN | denotes | polyubiquitination |
T21577 | 14133-14143 | JJ | denotes | K48-linked |
T21576 | 14129-14132 | DT | denotes | the |
T21575 | 14117-14128 | VB | denotes | facilitates |
T21574 | 14111-14116 | WDT | denotes | which |
T21573 | 14109-14110 | -COMMA- | denotes | , |
T21572 | 14102-14109 | NN | denotes | cIAP1/2 |
T21571 | 14098-14101 | CC | denotes | and |
T21570 | 14092-14097 | NN | denotes | TRAF3 |
T21569 | 14090-14091 | -COMMA- | denotes | , |
T21568 | 14085-14090 | NN | denotes | TRAF2 |
T21567 | 14077-14084 | NN | denotes | ligases |
T21566 | 14067-14076 | NN | denotes | ubiquitin |
T21565 | 14063-14066 | DT | denotes | the |
T21564 | 14058-14062 | IN | denotes | with |
T21563 | 14050-14057 | NN | denotes | complex |
T21562 | 14040-14049 | JJ | denotes | cytosolic |
T21561 | 14038-14039 | DT | denotes | a |
T21560 | 14032-14037 | VB | denotes | forms |
T21559 | 14028-14031 | NN | denotes | NIK |
T21558 | 14022-14027 | NN | denotes | cells |
T21557 | 14009-14021 | JJ | denotes | unstimulated |
T21556 | 14006-14008 | IN | denotes | In |
T21555 | 13998-14004 | NN | denotes | levels |
T21554 | 13987-13997 | NN | denotes | expression |
T21553 | 13985-13986 | -RRB- | denotes | ) |
T21552 | 13982-13985 | NN | denotes | NIK |
T21551 | 13981-13982 | -LRB- | denotes | ( |
T21550 | 13974-13980 | NN | denotes | kinase |
T21549 | 13965-13973 | VB | denotes | inducing |
T21548 | 13959-13964 | NN | denotes | NF-κB |
T21547 | 13956-13958 | IN | denotes | on |
T21546 | 13946-13955 | JJ | denotes | dependent |
T21545 | 13943-13945 | VB | denotes | is |
T21544 | 13938-13942 | WDT | denotes | that |
T21543 | 13930-13937 | NN | denotes | pathway |
T21542 | 13924-13929 | NN | denotes | NF-κB |
T21541 | 13911-13923 | JJ | denotes | noncanonical |
T21540 | 13907-13910 | DT | denotes | the |
T21539 | 13898-13906 | VB | denotes | activate |
T21538 | 13894-13897 | MD | denotes | can |
T21537 | 13889-13893 | NN | denotes | RANK |
T21536 | 13885-13888 | CC | denotes | and |
T21535 | 13880-13884 | NN | denotes | CD40 |
T21534 | 13868-13878 | NN | denotes | signalling |
T21533 | 13862-13867 | NN | denotes | NF-κB |
T21532 | 13849-13861 | JJ | denotes | Noncanonical |
T21605 | 14326-14344 | NN | denotes | polyubiquitination |
T21604 | 14315-14325 | JJ | denotes | K63-linked |
T21603 | 14300-14314 | JJ | denotes | nondegradative |
T21602 | 14292-14299 | VB | denotes | directs |
T21601 | 14286-14291 | NN | denotes | TRAF2 |
T21600 | 14280-14285 | WRB | denotes | where |
T21599 | 14278-14279 | -COMMA- | denotes | , |
T21598 | 14270-14278 | NN | denotes | receptor |
T21597 | 14266-14269 | DT | denotes | the |
T21596 | 14263-14265 | TO | denotes | to |
T21595 | 14253-14262 | VB | denotes | recruited |
T21609 | 14357-14366 | VB | denotes | resulting |
T21608 | 14355-14356 | -COMMA- | denotes | , |
T21607 | 14348-14355 | NN | denotes | cIAP1/2 |
T21606 | 14345-14347 | IN | denotes | of |
T20005 | 10717-10723 | NN | denotes | factor |
T20004 | 10708-10716 | NN | denotes | necrosis |
T20003 | 10701-10707 | NN | denotes | tumour |
T20002 | 10699-10700 | -COMMA- | denotes | , |
T20001 | 10696-10699 | NN | denotes | TNF |
T20000 | 10694-10695 | -COLON- | denotes | ; |
T19999 | 10686-10694 | NN | denotes | receptor |
T19998 | 10676-10685 | JJ | denotes | Toll-like |
T19997 | 10674-10675 | -COMMA- | denotes | , |
T19996 | 10671-10674 | NN | denotes | TLR |
T19995 | 10669-10670 | -COLON- | denotes | ; |
T19994 | 10663-10669 | NN | denotes | factor |
T19993 | 10643-10662 | JJ | denotes | receptor-associated |
T19992 | 10639-10642 | NN | denotes | TNF |
T19991 | 10637-10638 | -COMMA- | denotes | , |
T19990 | 10633-10637 | NN | denotes | TRAF |
T19989 | 10631-10632 | -COLON- | denotes | ; |
T19988 | 10617-10631 | NN | denotes | receptor/IL-1R |
T19987 | 10607-10616 | JJ | denotes | Toll-like |
T19986 | 10605-10606 | -COMMA- | denotes | , |
T19985 | 10602-10605 | NN | denotes | TIR |
T19984 | 10600-10601 | -COLON- | denotes | ; |
T19983 | 10584-10600 | JJ | denotes | receptor-related |
T19982 | 10558-10583 | NN | denotes | single-immunoglobulinIL-1 |
T19981 | 10556-10557 | -COMMA- | denotes | , |
T19980 | 10550-10556 | NN | denotes | SIGIRR |
T19979 | 10548-10549 | -COLON- | denotes | ; |
T19978 | 10547-10548 | CD | denotes | 1 |
T19977 | 10539-10546 | NN | denotes | protein |
T19976 | 10527-10538 | VB | denotes | interacting |
T19975 | 10518-10526 | NN | denotes | receptor |
T19974 | 10516-10517 | -COMMA- | denotes | , |
T19973 | 10512-10516 | NN | denotes | RIP1 |
T19972 | 10510-10511 | -COLON- | denotes | ; |
T19971 | 10505-10510 | NN | denotes | NF-κB |
T19970 | 10502-10504 | IN | denotes | of |
T19969 | 10492-10501 | NN | denotes | activator |
T19968 | 10483-10491 | NN | denotes | receptor |
T19967 | 10481-10482 | -COMMA- | denotes | , |
T19966 | 10477-10481 | NN | denotes | RANK |
T19965 | 10475-10476 | -COLON- | denotes | ; |
T19964 | 10469-10475 | NN | denotes | factor |
T19963 | 10461-10468 | JJ | denotes | nuclear |
T19962 | 10459-10460 | -COMMA- | denotes | , |
T19961 | 10457-10459 | NN | denotes | NF |
T19960 | 10455-10456 | -COLON- | denotes | ; |
T19959 | 10446-10455 | NN | denotes | modulator |
T19958 | 10436-10445 | JJ | denotes | essential |
T19957 | 10430-10435 | NN | denotes | NF-κB |
T19956 | 10428-10429 | -COMMA- | denotes | , |
T19955 | 10424-10428 | NN | denotes | NEMO |
T19954 | 10422-10423 | -COLON- | denotes | ; |
T19953 | 10420-10422 | CD | denotes | 88 |
T19952 | 10415-10419 | NN | denotes | gene |
T19951 | 10406-10414 | NN | denotes | response |
T19950 | 10398-10405 | JJ | denotes | primary |
T19949 | 10382-10397 | NN | denotes | differentiation |
T19948 | 10374-10381 | JJ | denotes | myeloid |
T19947 | 10372-10373 | -COMMA- | denotes | , |
T19946 | 10367-10372 | NN | denotes | MyD88 |
T19945 | 10365-10366 | -COLON- | denotes | ; |
T19944 | 10359-10365 | NN | denotes | kinase |
T19943 | 10342-10358 | JJ | denotes | IL-1R-associated |
T19942 | 10340-10341 | -COMMA- | denotes | , |
T19941 | 10336-10340 | NN | denotes | IRAK |
T19940 | 10334-10335 | -COLON- | denotes | ; |
T19939 | 10329-10334 | NN | denotes | NF-κB |
T19938 | 10326-10328 | IN | denotes | of |
T19937 | 10316-10325 | NN | denotes | inhibitor |
T19936 | 10314-10315 | -COMMA- | denotes | , |
T19935 | 10311-10314 | NN | denotes | IκB |
T19934 | 10309-10310 | -COLON- | denotes | ; |
T19933 | 10303-10309 | NN | denotes | kinase |
T19932 | 10299-10302 | NN | denotes | IκB |
T19931 | 10297-10298 | -COMMA- | denotes | , |
T19930 | 10294-10297 | NN | denotes | IKK |
T19929 | 10292-10293 | -COLON- | denotes | ; |
T19928 | 10277-10292 | NN | denotes | cylindromatosis |
T19927 | 10275-10276 | -COMMA- | denotes | , |
T19926 | 10271-10275 | NN | denotes | CYLD |
T19925 | 10269-10270 | -COLON- | denotes | ; |
T19924 | 10260-10269 | NN | denotes | apoptosis |
T19923 | 10257-10259 | IN | denotes | of |
T19922 | 10247-10256 | NN | denotes | inhibitor |
T19921 | 10238-10246 | JJ | denotes | cellular |
T19920 | 10236-10237 | -COMMA- | denotes | , |
T19919 | 10232-10236 | NN | denotes | cIAP |
T19918 | 10230-10231 | -COLON- | denotes | ; |
T19917 | 10225-10230 | NN | denotes | NF-κB |
T19916 | 10222-10224 | IN | denotes | of |
T19915 | 10212-10221 | NN | denotes | inhibitor |
T19914 | 10200-10211 | JJ | denotes | A20-binding |
T19913 | 10198-10199 | -COMMA- | denotes | , |
T19912 | 10194-10198 | NN | denotes | ABIN |
T19911 | 10182-10192 | NN | denotes | activation |
T19910 | 10176-10181 | NN | denotes | NF-κB |
T19909 | 10173-10175 | IN | denotes | of |
T19908 | 10162-10172 | NN | denotes | regulation |
T19907 | 10153-10161 | NN | denotes | feedback |
T19906 | 10144-10152 | JJ | denotes | negative |
T19905 | 10140-10143 | DT | denotes | the |
T19904 | 10137-10139 | IN | denotes | in |
T19903 | 10132-10136 | PRP | denotes | them |
T19902 | 10120-10131 | VB | denotes | implicating |
T19901 | 10118-10119 | -COMMA- | denotes | , |
T19900 | 10109-10118 | JJ | denotes | dependent |
T19899 | 10103-10108 | NN | denotes | NF-κB |
T19898 | 10100-10102 | VB | denotes | is |
T19897 | 10090-10099 | NN | denotes | molecules |
T19896 | 10079-10089 | JJ | denotes | regulatory |
T19895 | 10070-10078 | JJ | denotes | negative |
T19894 | 10064-10069 | DT | denotes | these |
T19893 | 10061-10063 | IN | denotes | of |
T19892 | 10056-10060 | JJ | denotes | many |
T19891 | 10053-10055 | IN | denotes | of |
T19890 | 10042-10052 | NN | denotes | expression |
T19889 | 10038-10041 | DT | denotes | The |
T19888 | 10031-10036 | NN | denotes | TRAF6 |
T19887 | 10027-10030 | CC | denotes | and |
T19886 | 10021-10026 | NN | denotes | IRAK1 |
T19885 | 10018-10020 | TO | denotes | to |
T19884 | 10010-10017 | VB | denotes | binding |
T19883 | 10006-10009 | IN | denotes | for |
T19882 | 10001-10005 | NN | denotes | TLR4 |
T19881 | 9996-10000 | IN | denotes | with |
T19880 | 9988-9995 | VB | denotes | compete |
T19879 | 9985-9987 | TO | denotes | to |
T19878 | 9976-9984 | VB | denotes | proposed |
T19877 | 9971-9975 | VB | denotes | been |
T19876 | 9967-9970 | VB | denotes | has |
T19875 | 9961-9966 | WDT | denotes | which |
T19874 | 9959-9960 | -COMMA- | denotes | , |
T19873 | 9953-9959 | NN | denotes | SIGIRR |
T19872 | 9945-9952 | NN | denotes | protein |
T19871 | 9931-9944 | JJ | denotes | transmembrane |
T19870 | 9927-9930 | DT | denotes | the |
T19869 | 9924-9926 | IN | denotes | by |
T19868 | 9914-9923 | VB | denotes | inhibited |
T19867 | 9911-9913 | VB | denotes | be |
T19866 | 9906-9910 | RB | denotes | also |
T19865 | 9902-9905 | MD | denotes | can |
T19864 | 9891-9901 | NN | denotes | signalling |
T19863 | 9887-9890 | NN | denotes | TLR |
T19862 | 9885-9886 | -COMMA- | denotes | , |
T19861 | 9878-9885 | RB | denotes | Finally |
T19860 | 9871-9876 | NN | denotes | TRAF6 |
T19859 | 9867-9870 | CC | denotes | and |
T19858 | 9861-9866 | NN | denotes | IRAK1 |
T19857 | 9858-9860 | IN | denotes | of |
T19856 | 9847-9857 | NN | denotes | expression |
T19855 | 9836-9846 | VB | denotes | inhibiting |
T19854 | 9833-9835 | IN | denotes | by |
T19853 | 9822-9832 | NN | denotes | signalling |
T19852 | 9818-9821 | NN | denotes | TLR |
T19851 | 9809-9817 | VB | denotes | regulate |
T19850 | 9798-9808 | RB | denotes | negatively |
T19849 | 9795-9797 | TO | denotes | to |
T19848 | 9787-9794 | VB | denotes | thought |
T19847 | 9784-9786 | VB | denotes | is |
T19846 | 9776-9783 | NN | denotes | miR-146 |
T19845 | 9771-9775 | NN | denotes | p62. |
T19844 | 9767-9770 | CC | denotes | and |
T19843 | 9760-9766 | NN | denotes | ABIN-1 |
T19842 | 9757-9759 | IN | denotes | as |
T19841 | 9752-9756 | JJ | denotes | such |
T19840 | 9743-9751 | NN | denotes | proteins |
T19839 | 9735-9742 | NN | denotes | adaptor |
T19838 | 9717-9734 | JJ | denotes | ubiquitin-binding |
T19837 | 9708-9716 | JJ | denotes | specific |
T19836 | 9702-9707 | VB | denotes | using |
T19835 | 9692-9701 | VB | denotes | recruited |
T19834 | 9688-9691 | VB | denotes | are |
T19833 | 9683-9687 | PRP | denotes | they |
T19832 | 9677-9682 | WDT | denotes | which |
T19831 | 9674-9676 | TO | denotes | to |
T19830 | 9672-9673 | -COMMA- | denotes | , |
T19829 | 9667-9672 | NN | denotes | TRAF6 |
T19828 | 9663-9666 | CC | denotes | and |
T19827 | 9658-9662 | NN | denotes | RIP1 |
T19826 | 9648-9657 | VB | denotes | including |
T19825 | 9639-9647 | NN | denotes | proteins |
T19824 | 9628-9638 | NN | denotes | signalling |
T19823 | 9619-9627 | JJ | denotes | specific |
T19822 | 9609-9618 | VB | denotes | targeting |
T19821 | 9606-9608 | IN | denotes | by |
T19820 | 9595-9605 | NN | denotes | activation |
T19819 | 9589-9594 | NN | denotes | NF-κB |
T19783 | 9356-9363 | NN | denotes | nucleus |
T19782 | 9352-9355 | DT | denotes | the |
T19781 | 9349-9351 | TO | denotes | to |
T19780 | 9337-9348 | VB | denotes | translocate |
T19779 | 9334-9336 | TO | denotes | to |
T19778 | 9332-9333 | -RRB- | denotes | ) |
T19777 | 9329-9332 | NN | denotes | p50 |
T19776 | 9325-9328 | CC | denotes | and |
T19775 | 9321-9324 | NN | denotes | p65 |
T19774 | 9318-9320 | IN | denotes | of |
T19773 | 9306-9317 | NN | denotes | heterodimer |
T19772 | 9304-9305 | DT | denotes | a |
T19771 | 9301-9303 | IN | denotes | as |
T19770 | 9295-9300 | VB | denotes | shown |
T19769 | 9290-9294 | RB | denotes | here |
T19768 | 9289-9290 | -LRB- | denotes | ( |
T19767 | 9283-9288 | NN | denotes | NF-κB |
T19766 | 9276-9282 | VB | denotes | allows |
T19765 | 9271-9275 | DT | denotes | This |
T19764 | 9258-9269 | NN | denotes | degradation |
T19763 | 9246-9257 | JJ | denotes | proteasomal |
T19762 | 9242-9245 | CC | denotes | and |
T19761 | 9227-9241 | NN | denotes | ubiquitination |
T19760 | 9216-9226 | JJ | denotes | K48-linked |
T19759 | 9212-9215 | PRP-DOLLAR- | denotes | its |
T19758 | 9201-9211 | VB | denotes | triggering |
T19757 | 9199-9200 | -COMMA- | denotes | , |
T19756 | 9195-9199 | NN | denotes | IκBα |
T19755 | 9180-9194 | VB | denotes | phosphorylates |
T19754 | 9175-9179 | NN | denotes | turn |
T19753 | 9172-9174 | IN | denotes | in |
T19752 | 9166-9171 | WDT | denotes | which |
T19751 | 9164-9165 | -COMMA- | denotes | , |
T19750 | 9160-9164 | NN | denotes | IKK2 |
T19749 | 9150-9159 | VB | denotes | activates |
T19748 | 9146-9149 | CC | denotes | and |
T19747 | 9131-9145 | VB | denotes | phosphorylates |
T19746 | 9126-9130 | RB | denotes | then |
T19745 | 9121-9125 | NN | denotes | TAK1 |
T19744 | 9115-9119 | NN | denotes | TAK1 |
T19743 | 9111-9114 | CC | denotes | and |
T19742 | 9106-9110 | NN | denotes | IKK2 |
T19741 | 9093-9105 | RB | denotes | respectively |
T19740 | 9090-9092 | IN | denotes | of |
T19739 | 9079-9089 | NN | denotes | activation |
T19738 | 9075-9078 | CC | denotes | and |
T19737 | 9063-9074 | NN | denotes | recruitment |
T19736 | 9059-9062 | DT | denotes | the |
T19735 | 9056-9058 | IN | denotes | in |
T19734 | 9046-9055 | VB | denotes | resulting |
T19733 | 9044-9045 | -COMMA- | denotes | , |
T19732 | 9036-9044 | NN | denotes | proteins |
T19731 | 9032-9035 | NN | denotes | TAB |
T19730 | 9028-9031 | CC | denotes | and |
T19729 | 9023-9027 | NN | denotes | NEMO |
T19728 | 9020-9022 | IN | denotes | by |
T19727 | 9009-9019 | VB | denotes | recognised |
T19726 | 9006-9008 | VB | denotes | is |
T19725 | 9004-9005 | -COMMA- | denotes | , |
T19724 | 8999-9004 | NN | denotes | IRAK1 |
T19723 | 8995-8998 | CC | denotes | and |
T19722 | 8990-8994 | NN | denotes | RIP1 |
T19721 | 8988-8989 | -COMMA- | denotes | , |
T19720 | 8983-8988 | NN | denotes | TRAFs |
T19719 | 8980-8982 | IN | denotes | of |
T19718 | 8961-8979 | NN | denotes | polyubiquitination |
T19717 | 8950-8960 | JJ | denotes | K63-linked |
T19716 | 8940-8948 | NN | denotes | receptor |
T19715 | 8936-8939 | DT | denotes | the |
T19714 | 8933-8935 | TO | denotes | to |
T19713 | 8931-8932 | -RRB- | denotes | ) |
T19712 | 8926-8931 | NN | denotes | cIAP2 |
T19711 | 8924-8925 | -COMMA- | denotes | , |
T19710 | 8919-8924 | NN | denotes | cIAP1 |
T19709 | 8917-8918 | -COMMA- | denotes | , |
T19708 | 8912-8917 | NN | denotes | TRAF6 |
T19707 | 8910-8911 | -COMMA- | denotes | , |
T19706 | 8905-8910 | NN | denotes | TRAF2 |
T19705 | 8904-8905 | -LRB- | denotes | ( |
T19704 | 8896-8903 | NN | denotes | ligases |
T19703 | 8886-8895 | NN | denotes | ubiquitin |
T19702 | 8882-8885 | CC | denotes | and |
T19701 | 8880-8881 | -COMMA- | denotes | , |
T19700 | 8879-8880 | -RRB- | denotes | ) |
T19699 | 8874-8879 | NN | denotes | IRAK4 |
T19698 | 8872-8873 | -COMMA- | denotes | , |
T19697 | 8867-8872 | NN | denotes | IRAK1 |
T19696 | 8865-8866 | -COMMA- | denotes | , |
T19695 | 8861-8865 | NN | denotes | RIP1 |
T19694 | 8860-8861 | -LRB- | denotes | ( |
T19693 | 8852-8859 | NN | denotes | kinases |
T19692 | 8850-8851 | -COMMA- | denotes | , |
T19691 | 8849-8850 | -RRB- | denotes | ) |
T19690 | 8848-8849 | -RRB- | denotes | ) |
T19689 | 8844-8848 | NN | denotes | TRIF |
T19688 | 8843-8844 | -LRB- | denotes | ( |
T19687 | 8838-8842 | NN | denotes | IFNβ |
T19686 | 8821-8837 | JJ | denotes | adaptor-inducing |
T19685 | 8803-8820 | JJ | denotes | domain-containing |
T19684 | 8799-8802 | NN | denotes | TIR |
T19683 | 8797-8798 | -COMMA- | denotes | , |
T19682 | 8794-8797 | NNP | denotes | MAL |
T19681 | 8792-8793 | -COMMA- | denotes | , |
T19680 | 8787-8792 | NN | denotes | MyD88 |
T19679 | 8785-8786 | -COMMA- | denotes | , |
T19678 | 8784-8785 | -RRB- | denotes | ) |
T19677 | 8779-8784 | NN | denotes | TRADD |
T19676 | 8778-8779 | -LRB- | denotes | ( |
T19675 | 8770-8777 | NN | denotes | protein |
T19674 | 8763-8769 | NN | denotes | domain |
T19673 | 8757-8762 | NN | denotes | death |
T19672 | 8744-8756 | JJ | denotes | 1-associated |
T19671 | 8735-8743 | NN | denotes | receptor |
T19670 | 8731-8734 | NN | denotes | TNF |
T19669 | 8730-8731 | -LRB- | denotes | ( |
T19668 | 8721-8729 | NN | denotes | proteins |
T19667 | 8713-8720 | NN | denotes | adaptor |
T19666 | 8704-8712 | JJ | denotes | specific |
T19665 | 8701-8703 | IN | denotes | of |
T19664 | 8689-8700 | NN | denotes | recruitment |
T19663 | 8685-8688 | DT | denotes | the |
T19662 | 8677-8684 | VB | denotes | trigger |
T19661 | 8672-8676 | NN | denotes | TLR4 |
T19660 | 8668-8671 | CC | denotes | and |
T19659 | 8666-8667 | -COMMA- | denotes | , |
T19658 | 8662-8666 | NN | denotes | RANK |
T19657 | 8660-8661 | -COMMA- | denotes | , |
T19656 | 8656-8660 | NN | denotes | CD40 |
T19655 | 8654-8655 | -COMMA- | denotes | , |
T19654 | 8649-8654 | NN | denotes | TNFR1 |
T19653 | 8646-8648 | IN | denotes | as |
T19652 | 8641-8645 | JJ | denotes | such |
T19651 | 8631-8640 | NN | denotes | receptors |
T19650 | 8622-8630 | NN | denotes | membrane |
T19649 | 8613-8621 | JJ | denotes | specific |
T19648 | 8610-8612 | IN | denotes | of |
T19647 | 8599-8609 | NN | denotes | engagement |
T19646 | 8592-8598 | NN | denotes | Ligand |
T19645 | 8580-8590 | NN | denotes | regulators |
T19644 | 8571-8579 | JJ | denotes | negative |
T19643 | 8567-8570 | CC | denotes | and |
T19642 | 8556-8566 | NN | denotes | signalling |
T19641 | 8550-8555 | NN | denotes | NF-κB |
T19640 | 8540-8549 | JJ | denotes | Canonical |
T19818 | 9581-9588 | VB | denotes | control |
T19817 | 9576-9580 | WDT | denotes | that |
T19816 | 9568-9575 | NN | denotes | enzymes |
T19815 | 9551-9567 | VB | denotes | deubiquitinating |
T19814 | 9547-9550 | VB | denotes | are |
T19813 | 9542-9546 | NN | denotes | CYLD |
T19812 | 9538-9541 | CC | denotes | and |
T19811 | 9534-9537 | NN | denotes | A20 |
T19810 | 9527-9532 | NN | denotes | TRAFs |
T19809 | 9521-9526 | JJ | denotes | other |
T19808 | 9516-9520 | IN | denotes | with |
T19807 | 9506-9515 | VB | denotes | competing |
T19806 | 9503-9505 | IN | denotes | by |
T19805 | 9494-9502 | RB | denotes | probably |
T19804 | 9489-9493 | RB | denotes | most |
T19803 | 9487-9488 | -COMMA- | denotes | , |
T19802 | 9477-9487 | NN | denotes | activation |
T19801 | 9471-9476 | NN | denotes | NF-κB |
T19800 | 9462-9470 | VB | denotes | regulate |
T19799 | 9451-9461 | RB | denotes | negatively |
T19798 | 9447-9450 | MD | denotes | can |
T19797 | 9445-9446 | -COMMA- | denotes | , |
T19796 | 9437-9445 | NN | denotes | activity |
T19795 | 9430-9436 | NN | denotes | ligase |
T19794 | 9420-9429 | NN | denotes | ubiquitin |
T19793 | 9417-9419 | DT | denotes | no |
T19792 | 9413-9416 | VB | denotes | has |
T19791 | 9407-9412 | WDT | denotes | which |
T19790 | 9405-9406 | -COMMA- | denotes | , |
T19789 | 9400-9405 | NN | denotes | TRAF1 |
T19788 | 9388-9398 | NN | denotes | expression |
T19787 | 9383-9387 | NN | denotes | gene |
T19786 | 9376-9382 | NN | denotes | target |
T19785 | 9368-9375 | VB | denotes | promote |
T19784 | 9364-9367 | CC | denotes | and |
T19033 | 33618-33630 | JJ | denotes | inflammatory |
T19032 | 33614-33617 | IN | denotes | for |
T19031 | 33603-33613 | NN | denotes | treatments |
T19030 | 33599-33602 | JJ | denotes | new |
T19029 | 33596-33598 | TO | denotes | to |
T19028 | 33591-33595 | VB | denotes | lead |
T19027 | 33587-33590 | MD | denotes | may |
T19026 | 33577-33586 | NN | denotes | knowledge |
T19025 | 33572-33576 | DT | denotes | this |
T19024 | 33568-33571 | WRB | denotes | how |
T19023 | 33566-33567 | -COMMA- | denotes | , |
T19022 | 33555-33566 | RB | denotes | importantly |
T19021 | 33550-33554 | RB | denotes | more |
T19020 | 33548-33549 | -COMMA- | denotes | , |
T19019 | 33545-33548 | CC | denotes | and |
T19018 | 33543-33544 | -COMMA- | denotes | , |
T19017 | 33534-33543 | VB | denotes | organised |
T19016 | 33531-33533 | VB | denotes | is |
T19015 | 33520-33530 | NN | denotes | signalling |
T19014 | 33514-33519 | NN | denotes | NF-κB |
T19013 | 33510-33513 | WRB | denotes | how |
T19012 | 33502-33509 | VB | denotes | clarify |
T19011 | 33499-33501 | TO | denotes | to |
T19010 | 33493-33498 | NN | denotes | order |
T19009 | 33490-33492 | IN | denotes | in |
T19008 | 33481-33489 | NN | denotes | question |
T19007 | 33471-33480 | JJ | denotes | important |
T19006 | 33468-33470 | DT | denotes | an |
T19005 | 33465-33467 | VB | denotes | be |
T19004 | 33460-33464 | MD | denotes | will |
T19003 | 33450-33459 | VB | denotes | regulated |
T19002 | 33439-33449 | PRP | denotes | themselves |
T19001 | 33435-33438 | VB | denotes | are |
T19000 | 33427-33434 | NN | denotes | signals |
T18999 | 33416-33426 | JJ | denotes | regulatory |
T18998 | 33410-33415 | DT | denotes | these |
T18997 | 33406-33409 | PDT | denotes | all |
T18996 | 33402-33405 | WRB | denotes | How |
T18995 | 33392-33400 | VB | denotes | expected |
T18994 | 33389-33391 | VB | denotes | be |
T18993 | 33385-33388 | MD | denotes | can |
T18992 | 33374-33384 | NN | denotes | complexity |
T18991 | 33366-33373 | JJ | denotes | intense |
T18990 | 33364-33365 | -COMMA- | denotes | , |
T18989 | 33358-33364 | VB | denotes | target |
T18988 | 33353-33357 | PRP | denotes | they |
T18987 | 33347-33352 | NN | denotes | mRNAs |
T18986 | 33338-33346 | JJ | denotes | multiple |
T18985 | 33334-33337 | DT | denotes | the |
T18984 | 33330-33333 | CC | denotes | and |
T18983 | 33323-33329 | NN | denotes | humans |
T18982 | 33320-33322 | IN | denotes | in |
T18981 | 33313-33319 | NN | denotes | miRNAs |
T18980 | 33310-33312 | IN | denotes | of |
T18979 | 33303-33309 | NN | denotes | number |
T18978 | 33299-33302 | DT | denotes | the |
T18977 | 33293-33298 | VB | denotes | given |
T18976 | 33291-33292 | -COMMA- | denotes | , |
T18975 | 33283-33291 | NN | denotes | addition |
T18974 | 33280-33282 | IN | denotes | In |
T18973 | 33274-33278 | PRP | denotes | them |
T18972 | 33266-33273 | IN | denotes | between |
T18971 | 33253-33265 | NN | denotes | relationship |
T18970 | 33249-33252 | DT | denotes | the |
T18969 | 33245-33248 | CC | denotes | and |
T18968 | 33234-33244 | NN | denotes | regulators |
T18967 | 33228-33233 | DT | denotes | these |
T18966 | 33225-33227 | IN | denotes | of |
T18965 | 33220-33224 | DT | denotes | each |
T18964 | 33217-33219 | IN | denotes | of |
T18963 | 33212-33216 | NN | denotes | role |
T18962 | 33203-33211 | JJ | denotes | specific |
T18961 | 33199-33202 | DT | denotes | the |
T18960 | 33196-33198 | IN | denotes | of |
T18959 | 33187-33195 | NN | denotes | question |
T18958 | 33183-33186 | DT | denotes | the |
T18957 | 33176-33182 | VB | denotes | raises |
T18956 | 33174-33175 | -COMMA- | denotes | , |
T18955 | 33167-33174 | RB | denotes | however |
T18954 | 33165-33166 | -COMMA- | denotes | , |
T18953 | 33158-33165 | NN | denotes | pathway |
T18952 | 33152-33157 | NN | denotes | NF-κB |
T18951 | 33148-33151 | DT | denotes | the |
T18950 | 33145-33147 | IN | denotes | of |
T18949 | 33134-33144 | NN | denotes | regulation |
T18948 | 33128-33133 | JJ | denotes | tight |
T18947 | 33126-33127 | DT | denotes | a |
T18946 | 33117-33125 | VB | denotes | ensuring |
T18945 | 33106-33116 | NN | denotes | regulators |
T18944 | 33097-33105 | JJ | denotes | negative |
T18943 | 33088-33096 | JJ | denotes | multiple |
T18942 | 33085-33087 | IN | denotes | of |
T18941 | 33075-33084 | NN | denotes | existence |
T18940 | 33071-33074 | DT | denotes | The |
T18939 | 33057-33069 | NN | denotes | therapeutics |
T18938 | 33048-33056 | JJ | denotes | specific |
T18937 | 33045-33047 | IN | denotes | of |
T18936 | 33038-33044 | NN | denotes | design |
T18935 | 33034-33037 | DT | denotes | the |
T18934 | 33030-33033 | IN | denotes | for |
T18933 | 33020-33029 | JJ | denotes | important |
T18932 | 33015-33019 | RB | denotes | very |
T18931 | 33012-33014 | VB | denotes | be |
T18930 | 33007-33011 | RB | denotes | thus |
T18929 | 33003-33006 | MD | denotes | can |
T18928 | 32995-33002 | NN | denotes | control |
T18927 | 32989-32994 | IN | denotes | under |
T18926 | 32978-32988 | NN | denotes | activation |
T18925 | 32972-32977 | NN | denotes | NF-κB |
T18924 | 32964-32971 | VB | denotes | Keeping |
T18923 | 32951-32962 | NN | denotes | destruction |
T18922 | 32946-32950 | NN | denotes | bone |
T18921 | 32942-32945 | CC | denotes | and |
T18920 | 32932-32941 | NN | denotes | cartilage |
T18919 | 32929-32931 | TO | denotes | to |
T18918 | 32921-32928 | VB | denotes | leading |
T18917 | 32918-32920 | NN | denotes | RA |
T18916 | 32915-32917 | IN | denotes | in |
T18915 | 32905-32914 | NN | denotes | processes |
T18914 | 32892-32904 | JJ | denotes | inflammatory |
T18913 | 32888-32891 | DT | denotes | the |
T18912 | 32885-32887 | IN | denotes | in |
T18911 | 32879-32884 | NN | denotes | roles |
T18910 | 32871-32878 | JJ | denotes | crucial |
T18909 | 32865-32870 | VB | denotes | plays |
T18908 | 32857-32864 | NN | denotes | factors |
T18907 | 32843-32856 | NN | denotes | transcription |
T18906 | 32840-32842 | IN | denotes | of |
T18905 | 32833-32839 | NN | denotes | family |
T18904 | 32827-32832 | NN | denotes | NF-κB |
T18903 | 32823-32826 | DT | denotes | The |
T17797 | 31717-31729 | NN | denotes | pathogenesis |
T17796 | 31713-31716 | DT | denotes | the |
T17795 | 31710-31712 | IN | denotes | in |
T17794 | 31702-31709 | NN | denotes | process |
T17793 | 31698-31701 | JJ | denotes | key |
T17792 | 31696-31697 | DT | denotes | a |
T17791 | 31694-31695 | -COMMA- | denotes | , |
T17790 | 31684-31694 | NN | denotes | production |
T17789 | 31680-31683 | NN | denotes | TNF |
T17788 | 31672-31679 | VB | denotes | promote |
T17787 | 31669-31671 | TO | denotes | to |
T17786 | 31663-31668 | VB | denotes | shown |
T17785 | 31659-31662 | VB | denotes | was |
T17784 | 31651-31658 | NN | denotes | miR-155 |
T17783 | 31649-31650 | -COMMA- | denotes | , |
T17782 | 31641-31649 | RB | denotes | Moreover |
T17781 | 31613-31614 | -RRB- | denotes | s |
T17780 | 31611-31613 | CD | denotes | is |
T17779 | 31610-31611 | -LRB- | denotes | t |
T17778 | 31608-31610 | NN | denotes | e |
T17777 | 31606-31608 | IN | denotes | at |
T17776 | 31595-31606 | NN | denotes | s that medi |
T17775 | 31589-31595 | NN | denotes | einase |
T17774 | 31582-31589 | VB | denotes | lloprot |
T17773 | 31578-31582 | WDT | denotes | meta |
T17772 | 31559-31577 | NN | denotes | of specific matrix |
T17771 | 31553-31559 | NN | denotes | ssion |
T17770 | 31545-31553 | JJ | denotes | le expre |
T17769 | 31543-31545 | IN | denotes | ib |
T17768 | 31533-31543 | NN | denotes | kine-induc |
T17767 | 31515-31533 | JJ | denotes | t the TLR and cyto |
T17766 | 31512-31515 | CC | denotes | ven |
T17765 | 31509-31512 | NN | denotes | pre |
T17764 | 31506-31509 | DT | denotes | to |
T17763 | 31499-31506 | VB | denotes | s able |
T17762 | 31497-31499 | TO | denotes | wa |
T17761 | 31493-31497 | JJ | denotes | sts |
T17760 | 31490-31493 | VB | denotes | bla |
T17759 | 31479-31490 | NN | denotes | ovial fibro |
T17758 | 31471-31479 | JJ | denotes | n in syn |
T17757 | 31469-31471 | IN | denotes | io |
T17756 | 31455-31469 | NN | denotes | 55 overexpress |
T17755 | 31448-31455 | NN | denotes | . miR-1 |
T17754 | 31447-31448 | -RRB- | denotes | ] |
T17753 | 31445-31447 | CD | denotes | 86 |
T17752 | 31444-31445 | -LRB- | denotes | [ |
T17751 | 31429-31443 | NN | denotes | susceptibility |
T17750 | 31426-31428 | NN | denotes | RA |
T17749 | 31421-31425 | IN | denotes | with |
T17748 | 31410-31420 | VB | denotes | associated |
T17747 | 31407-31409 | VB | denotes | be |
T17746 | 31404-31406 | TO | denotes | to |
T17745 | 31398-31403 | VB | denotes | shown |
T17744 | 31389-31397 | RB | denotes | recently |
T17743 | 31385-31388 | VB | denotes | was |
T17742 | 31380-31384 | NN | denotes | gene |
T17741 | 31373-31379 | NN | denotes | target |
T17740 | 31364-31372 | NN | denotes | miR-146a |
T17739 | 31360-31363 | DT | denotes | the |
T17738 | 31357-31359 | IN | denotes | of |
T17737 | 31350-31356 | NN | denotes | 3'-UTR |
T17736 | 31346-31349 | DT | denotes | the |
T17735 | 31343-31345 | IN | denotes | in |
T17734 | 31330-31342 | NN | denotes | polymorphism |
T17733 | 31328-31329 | DT | denotes | a |
T17732 | 31326-31327 | -COMMA- | denotes | , |
T17731 | 31313-31326 | RB | denotes | Interestingly |
T17730 | 31298-31299 | -RRB- | denotes | i |
T17729 | 31293-31298 | CD | denotes | A pat |
T17728 | 31292-31293 | -LRB- | denotes | R |
T17727 | 31283-31291 | NN | denotes | lls from |
T17726 | 31281-31283 | NN | denotes | ce |
T17725 | 31276-31280 | IN | denotes | ng T |
T17724 | 31271-31276 | NN | denotes | oduci |
T17723 | 31270-31271 | NN | denotes | r |
T17722 | 31255-31270 | JJ | denotes | D4+ and IL-17-p |
T17721 | 31252-31255 | CC | denotes | n C |
T17720 | 31248-31252 | JJ | denotes | ed i |
T17719 | 31246-31248 | IN | denotes | ss |
T17718 | 31233-31246 | VB | denotes | lso overexpre |
T17717 | 31229-31233 | RB | denotes | is a |
T17716 | 31226-31228 | VB | denotes | 6a |
T17715 | 31218-31226 | NN | denotes | . miR-14 |
T17714 | 31217-31218 | -RRB- | denotes | ] |
T17713 | 31215-31217 | CD | denotes | 83 |
T17712 | 31214-31215 | -LRB- | denotes | [ |
T17711 | 31205-31213 | NN | denotes | patients |
T17710 | 31202-31204 | NN | denotes | RA |
T17709 | 31199-31201 | IN | denotes | of |
T17708 | 31193-31198 | NN | denotes | cells |
T17707 | 31181-31192 | JJ | denotes | mononuclear |
T17706 | 31175-31180 | NN | denotes | blood |
T17705 | 31164-31174 | JJ | denotes | peripheral |
T17704 | 31161-31163 | IN | denotes | in |
T17703 | 31158-31160 | IN | denotes | as |
T17702 | 31153-31157 | RB | denotes | well |
T17701 | 31150-31152 | RB | denotes | as |
T17700 | 31148-31149 | -COMMA- | denotes | , |
T17699 | 31147-31148 | -RRB- | denotes | ] |
T17698 | 31142-31147 | CD | denotes | 81,82 |
T17697 | 31141-31142 | -LRB- | denotes | [ |
T17696 | 31134-31140 | NN | denotes | tissue |
T17695 | 31125-31133 | JJ | denotes | synovial |
T17694 | 31121-31124 | CC | denotes | and |
T17693 | 31109-31120 | NN | denotes | fibroblasts |
T17692 | 31100-31108 | JJ | denotes | synovial |
T17691 | 31097-31099 | NN | denotes | RA |
T17690 | 31094-31096 | IN | denotes | in |
T17689 | 31087-31093 | NN | denotes | levels |
T17688 | 31080-31086 | JJ | denotes | higher |
T17687 | 31077-31079 | IN | denotes | at |
T17686 | 31067-31076 | VB | denotes | expressed |
T17685 | 31063-31066 | VB | denotes | are |
T17684 | 31055-31062 | NN | denotes | miR-155 |
T17683 | 31051-31054 | CC | denotes | and |
T17682 | 31043-31050 | NN | denotes | miR-146 |
T17681 | 31038-31042 | CC | denotes | both |
T17680 | 31036-31037 | -COMMA- | denotes | , |
T17679 | 31029-31036 | RB | denotes | Notably |
T17678 | 31026-31027 | -RRB- | denotes | ] |
T17677 | 31021-31026 | CD | denotes | 79,80 |
T17676 | 31020-31021 | -LRB- | denotes | [ |
T17675 | 31015-31019 | NN | denotes | RIP1 |
T17674 | 31011-31014 | CC | denotes | and |
T17673 | 31006-31010 | NN | denotes | IKKε |
T17672 | 30996-31005 | NN | denotes | molecules |
T17671 | 30985-30995 | NN | denotes | signalling |
T17670 | 30979-30984 | NN | denotes | NF-κB |
T17669 | 30975-30978 | DT | denotes | the |
T17668 | 30971-30974 | IN | denotes | for |
T17667 | 30959-30970 | NN | denotes | transcripts |
T17666 | 30952-30958 | NN | denotes | target |
T17665 | 30949-30951 | TO | denotes | to |
T17664 | 30943-30948 | VB | denotes | shown |
T17663 | 30939-30942 | VB | denotes | was |
T17662 | 30931-30938 | NN | denotes | miR-155 |
T17661 | 30929-30930 | -COMMA- | denotes | , |
T17660 | 30920-30929 | RB | denotes | Similarly |
T17659 | 30917-30918 | -RRB- | denotes | ) |
T17658 | 30916-30917 | CD | denotes | 1 |
T17657 | 30909-30915 | NN | denotes | Figure |
T17656 | 30908-30909 | -LRB- | denotes | ( |
T17655 | 30906-30907 | -RRB- | denotes | ] |
T17654 | 30904-30906 | CD | denotes | 78 |
T17653 | 30903-30904 | -LRB- | denotes | [ |
T17652 | 30894-30902 | NN | denotes | miR-146a |
T17651 | 30891-30893 | IN | denotes | of |
T17650 | 30885-30890 | NN | denotes | genes |
T17649 | 30878-30884 | NN | denotes | target |
T17648 | 30875-30877 | IN | denotes | as |
T17647 | 30864-30874 | VB | denotes | identified |
T17646 | 30859-30863 | VB | denotes | were |
T17645 | 30853-30858 | NN | denotes | TRAF6 |
T17644 | 30849-30852 | CC | denotes | and |
T17643 | 30843-30848 | NN | denotes | IRAK1 |
T17642 | 30833-30842 | NN | denotes | molecules |
T17641 | 30822-30832 | NN | denotes | signalling |
T17640 | 30816-30821 | NN | denotes | NF-κB |
T17639 | 30812-30815 | DT | denotes | the |
T17638 | 30808-30811 | CC | denotes | and |
T17637 | 30806-30807 | -COMMA- | denotes | , |
T17636 | 30802-30806 | NN | denotes | gene |
T17635 | 30786-30801 | JJ | denotes | NF-κB-dependent |
T17634 | 30783-30785 | DT | denotes | an |
T17633 | 30780-30782 | VB | denotes | is |
T17632 | 30771-30779 | NN | denotes | miR-146a |
T17631 | 30769-30770 | -COMMA- | denotes | , |
T17630 | 30761-30769 | NN | denotes | addition |
T17629 | 30758-30760 | IN | denotes | In |
T17628 | 30755-30756 | -RRB- | denotes | ] |
T17627 | 30750-30755 | CD | denotes | 78,79 |
T17626 | 30749-30750 | -LRB- | denotes | [ |
T17625 | 30744-30748 | NN | denotes | TLRs |
T17624 | 30740-30743 | CC | denotes | and |
T17623 | 30736-30739 | NN | denotes | TNF |
T17622 | 30734-30735 | -COMMA- | denotes | , |
T17621 | 30729-30734 | NN | denotes | IL-1β |
T17620 | 30726-30728 | IN | denotes | as |
T17619 | 30721-30725 | JJ | denotes | such |
T17618 | 30713-30720 | NN | denotes | stimuli |
T17617 | 30700-30712 | JJ | denotes | inflammatory |
T17616 | 30697-30699 | IN | denotes | by |
T17615 | 30689-30696 | VB | denotes | induced |
T17614 | 30686-30688 | VB | denotes | be |
T17613 | 30682-30685 | MD | denotes | can |
T17612 | 30675-30681 | NN | denotes | miRNAs |
T17611 | 30669-30674 | DT | denotes | these |
T17610 | 30663-30668 | IN | denotes | since |
T17609 | 30661-30662 | -COMMA- | denotes | , |
T17608 | 30656-30661 | NN | denotes | NF-κB |
T17607 | 30653-30655 | TO | denotes | to |
T17606 | 30642-30652 | NN | denotes | signalling |
T17605 | 30629-30641 | JJ | denotes | inflammatory |
T17604 | 30625-30628 | IN | denotes | for |
T17603 | 30616-30624 | NN | denotes | interest |
T17602 | 30605-30615 | JJ | denotes | particular |
T17601 | 30602-30604 | IN | denotes | of |
T17600 | 30598-30601 | VB | denotes | are |
T17599 | 30590-30597 | NN | denotes | miR-155 |
T17598 | 30586-30589 | CC | denotes | and |
T17597 | 30575-30585 | NN | denotes | miR-146a/b |
T17596 | 30572-30573 | -RRB- | denotes | ] |
T17595 | 30570-30572 | CD | denotes | 77 |
T17594 | 30569-30570 | -LRB- | denotes | [ |
T17593 | 30557-30568 | NN | denotes | degradation |
T17592 | 30552-30556 | NN | denotes | mRNA |
T17591 | 30545-30551 | NN | denotes | target |
T17590 | 30542-30544 | IN | denotes | of |
T17589 | 30532-30541 | NN | denotes | promotion |
T17588 | 30528-30531 | DT | denotes | the |
T17587 | 30524-30527 | CC | denotes | and |
T17586 | 30513-30523 | NN | denotes | expression |
T17585 | 30505-30512 | NN | denotes | protein |
T17584 | 30502-30504 | IN | denotes | of |
T17583 | 30491-30501 | NN | denotes | repression |
T17582 | 30487-30490 | DT | denotes | the |
T17979 | 32807-32808 | -RRB- | denotes | ] |
T17978 | 32799-32807 | CD | denotes | 83,88,91 |
T17977 | 32798-32799 | -LRB- | denotes | [ |
T17976 | 32785-32797 | NN | denotes | pathogenesis |
T17975 | 32781-32784 | IN | denotes | for |
T17974 | 32770-32780 | NN | denotes | biomarkers |
T17973 | 32759-32769 | JJ | denotes | diagnostic |
T17972 | 32756-32758 | IN | denotes | as |
T17971 | 32746-32755 | NN | denotes | potential |
T17970 | 32740-32745 | PRP-DOLLAR- | denotes | their |
T17969 | 32729-32739 | VB | denotes | indicating |
T17968 | 32727-32728 | -COMMA- | denotes | , |
T17967 | 32719-32727 | NN | denotes | patients |
T17966 | 32716-32718 | NN | denotes | RA |
T17965 | 32713-32715 | IN | denotes | in |
T17964 | 32702-32712 | NN | denotes | expression |
T17963 | 32694-32701 | VB | denotes | altered |
T17962 | 32691-32693 | DT | denotes | an |
T17961 | 32686-32690 | VB | denotes | have |
T17960 | 32683-32685 | TO | denotes | to |
T17959 | 32677-32682 | VB | denotes | shown |
T17958 | 32672-32676 | RB | denotes | also |
T17957 | 32667-32671 | VB | denotes | were |
T17956 | 32659-32666 | NN | denotes | miR-223 |
T17955 | 32655-32658 | CC | denotes | and |
T17954 | 32653-32654 | -COMMA- | denotes | , |
T17953 | 32646-32653 | NN | denotes | miR-132 |
T17952 | 32644-32645 | -COMMA- | denotes | , |
T17951 | 32638-32644 | NN | denotes | miR-16 |
T17950 | 32636-32637 | -COMMA- | denotes | , |
T17949 | 32629-32636 | RB | denotes | Finally |
T17948 | 32626-32627 | -RRB- | denotes | ] |
T17947 | 32624-32626 | CD | denotes | 90 |
T17946 | 32623-32624 | -LRB- | denotes | [ |
T17945 | 32611-32622 | NN | denotes | fibroblasts |
T17944 | 32602-32610 | JJ | denotes | synovial |
T17943 | 32599-32601 | NN | denotes | RA |
T17942 | 32596-32598 | IN | denotes | in |
T17941 | 32587-32595 | VB | denotes | detected |
T17940 | 32582-32586 | VB | denotes | were |
T17939 | 32580-32581 | -COLON- | denotes | - |
T17938 | 32575-32579 | NN | denotes | IL-6 |
T17937 | 32571-32574 | CC | denotes | and |
T17936 | 32551-32570 | NN | denotes | metalloproteinase-1 |
T17935 | 32544-32550 | NN | denotes | matrix |
T17934 | 32541-32543 | IN | denotes | of |
T17933 | 32531-32540 | NN | denotes | secretion |
T17932 | 32521-32530 | VB | denotes | increased |
T17931 | 32518-32520 | TO | denotes | to |
T17930 | 32510-32517 | VB | denotes | leading |
T17929 | 32508-32509 | -COLON- | denotes | - |
T17928 | 32500-32507 | NN | denotes | miR-203 |
T17927 | 32497-32499 | IN | denotes | of |
T17926 | 32490-32496 | NN | denotes | levels |
T17925 | 32481-32489 | JJ | denotes | elevated |
T17924 | 32479-32480 | -COMMA- | denotes | , |
T17923 | 32470-32479 | RB | denotes | Similarly |
T17922 | 32467-32468 | -RRB- | denotes | ] |
T17921 | 32465-32467 | CD | denotes | 89 |
T17920 | 32464-32465 | -LRB- | denotes | [ |
T17919 | 32455-32463 | NN | denotes | patients |
T17918 | 32452-32454 | NN | denotes | RA |
T17917 | 32447-32451 | IN | denotes | from |
T17916 | 32434-32446 | NN | denotes | synoviocytes |
T17915 | 32431-32433 | IN | denotes | in |
T17914 | 32421-32430 | VB | denotes | decreased |
T17913 | 32418-32420 | VB | denotes | be |
T17912 | 32415-32417 | TO | denotes | to |
T17911 | 32409-32414 | VB | denotes | shown |
T17910 | 32405-32408 | VB | denotes | was |
T17909 | 32403-32404 | -COLON- | denotes | - |
T17908 | 32401-32402 | CD | denotes | 1 |
T17907 | 32393-32400 | NN | denotes | protein |
T17906 | 32377-32392 | NN | denotes | chemoattractant |
T17905 | 32368-32376 | NN | denotes | monocyte |
T17904 | 32358-32367 | NN | denotes | chemokine |
T17903 | 32354-32357 | DT | denotes | the |
T17902 | 32351-32353 | IN | denotes | of |
T17901 | 32341-32350 | NN | denotes | regulator |
T17900 | 32337-32340 | JJ | denotes | key |
T17899 | 32335-32336 | DT | denotes | a |
T17898 | 32333-32334 | -COLON- | denotes | - |
T17897 | 32324-32332 | NN | denotes | miR-124a |
T17896 | 32322-32323 | -COMMA- | denotes | , |
T17895 | 32315-32322 | NN | denotes | context |
T17894 | 32310-32314 | DT | denotes | this |
T17893 | 32307-32309 | IN | denotes | In |
T17892 | 32295-32305 | VB | denotes | identified |
T17891 | 32286-32294 | RB | denotes | recently |
T17890 | 32281-32285 | VB | denotes | were |
T17889 | 32271-32280 | NN | denotes | pathology |
T17888 | 32268-32270 | NN | denotes | RA |
T17887 | 32265-32267 | IN | denotes | in |
T17886 | 32255-32264 | NN | denotes | responses |
T17885 | 32242-32254 | JJ | denotes | inflammatory |
T17884 | 32226-32241 | JJ | denotes | NF-κB-dependent |
T17883 | 32223-32225 | IN | denotes | of |
T17882 | 32215-32222 | NN | denotes | control |
T17881 | 32211-32214 | DT | denotes | the |
T17880 | 32208-32210 | IN | denotes | in |
T17879 | 32203-32207 | NN | denotes | role |
T17878 | 32193-32202 | JJ | denotes | potential |
T17877 | 32191-32192 | DT | denotes | a |
T17876 | 32186-32190 | IN | denotes | with |
T17875 | 32179-32185 | NN | denotes | miRNAs |
T17874 | 32173-32178 | JJ | denotes | other |
T17873 | 32170-32172 | IN | denotes | of |
T17872 | 32163-32169 | NN | denotes | number |
T17871 | 32161-32162 | DT | denotes | a |
T17870 | 32159-32160 | -COMMA- | denotes | , |
T17869 | 32152-32159 | NN | denotes | miR-155 |
T17868 | 32148-32151 | CC | denotes | and |
T17867 | 32140-32147 | NN | denotes | miR-146 |
T17866 | 32132-32139 | IN | denotes | Besides |
T17865 | 32124-32130 | NN | denotes | cohort |
T17864 | 32111-32123 | JJ | denotes | well-defined |
T17863 | 32107-32110 | CC | denotes | and |
T17862 | 32101-32106 | JJ | denotes | large |
T17861 | 32099-32100 | DT | denotes | a |
T17860 | 32093-32098 | VB | denotes | using |
T17859 | 32080-32092 | NN | denotes | confirmation |
T17858 | 32072-32079 | VB | denotes | require |
T17857 | 32067-32071 | MD | denotes | will |
T17856 | 32062-32066 | DT | denotes | this |
T17855 | 32058-32061 | CC | denotes | but |
T17854 | 32056-32057 | -COMMA- | denotes | , |
T17853 | 32055-32056 | -RRB- | denotes | ] |
T17852 | 32053-32055 | CD | denotes | 88 |
T17851 | 32052-32053 | -LRB- | denotes | [ |
T17850 | 32043-32051 | NN | denotes | efficacy |
T17849 | 32033-32042 | NN | denotes | treatment |
T17848 | 32030-32032 | CC | denotes | or |
T17847 | 32028-32029 | -COMMA- | denotes | , |
T17846 | 32017-32028 | NN | denotes | progression |
T17845 | 32015-32016 | -COMMA- | denotes | , |
T17844 | 32006-32015 | NN | denotes | diagnosis |
T17843 | 31998-32005 | NN | denotes | disease |
T17842 | 31994-31997 | IN | denotes | for |
T17841 | 31987-31993 | NN | denotes | marker |
T17840 | 31985-31986 | DT | denotes | a |
T17839 | 31982-31984 | IN | denotes | as |
T17838 | 31975-31981 | JJ | denotes | useful |
T17837 | 31963-31974 | RB | denotes | potentially |
T17836 | 31960-31962 | VB | denotes | is |
T17835 | 31951-31959 | NN | denotes | patients |
T17834 | 31948-31950 | NN | denotes | RA |
T17833 | 31945-31947 | IN | denotes | in |
T17832 | 31934-31944 | NN | denotes | expression |
T17831 | 31924-31933 | VB | denotes | increased |
T17830 | 31918-31923 | PRP-DOLLAR- | denotes | their |
T17829 | 31916-31917 | -COMMA- | denotes | , |
T17828 | 31908-31916 | NN | denotes | addition |
T17827 | 31905-31907 | IN | denotes | In |
T17826 | 31871-31882 | JJ | denotes | of new trea |
T17825 | 31869-31871 | VB | denotes | t |
T17824 | 31859-31869 | NN | denotes | developmen |
T17823 | 31855-31858 | JJ | denotes | the |
T17822 | 31852-31854 | IN | denotes | or |
T17821 | 31841-31852 | NN | denotes | potential f |
T17820 | 31838-31841 | DT | denotes | ir |
T17819 | 31835-31838 | IN | denotes | the |
T17818 | 31825-31834 | NN | denotes | in RA and |
T17817 | 31820-31825 | PRP-DOLLAR- | denotes | tion |
T17816 | 31817-31820 | CC | denotes | mma |
T17815 | 31815-31817 | NN | denotes | la |
T17814 | 31813-31815 | IN | denotes | nf |
T17813 | 31801-31813 | NN | denotes | ulators of i |
T17812 | 31799-31801 | IN | denotes | eg |
T17811 | 31789-31799 | NN | denotes | negative r |
T17810 | 31780-31788 | JJ | denotes | mportant |
T17809 | 31771-31780 | JJ | denotes | fore be i |
T17808 | 31769-31771 | VB | denotes | re |
T17807 | 31760-31769 | RB | denotes | 5 may the |
T17806 | 31757-31760 | MD | denotes | -15 |
T17805 | 31750-31757 | NN | denotes | and miR |
T17804 | 31747-31750 | CC | denotes | 46 |
T17803 | 31740-31747 | NN | denotes | . miR-1 |
T17802 | 31739-31740 | -RRB- | denotes | ] |
T17801 | 31737-31739 | CD | denotes | 87 |
T17800 | 31736-31737 | -LRB- | denotes | [ |
T17799 | 31733-31735 | NN | denotes | RA |
T17798 | 31730-31732 | IN | denotes | of |
T17581 | 30484-30486 | TO | denotes | to |
T17580 | 30476-30483 | VB | denotes | leading |
T17579 | 30470-30475 | NN | denotes | mRNAs |
T17578 | 30463-30469 | NN | denotes | target |
T17577 | 30460-30462 | IN | denotes | of |
T17576 | 30453-30459 | NN | denotes | 3'-UTR |
T17575 | 30449-30452 | DT | denotes | the |
T17574 | 30444-30448 | VB | denotes | bind |
T17573 | 30439-30443 | PRP | denotes | They |
T17572 | 30425-30437 | NN | denotes | inflammation |
T17571 | 30421-30424 | CC | denotes | and |
T17570 | 30411-30420 | NN | denotes | responses |
T17569 | 30404-30410 | JJ | denotes | immune |
T17568 | 30394-30403 | VB | denotes | including |
T17567 | 30392-30393 | -COMMA- | denotes | , |
T17566 | 30383-30392 | NN | denotes | processes |
T17565 | 30369-30382 | JJ | denotes | developmental |
T17564 | 30365-30368 | CC | denotes | and |
T17563 | 30356-30364 | JJ | denotes | cellular |
T17562 | 30351-30355 | JJ | denotes | many |
T17561 | 30348-30350 | IN | denotes | in |
T17560 | 30338-30347 | JJ | denotes | essential |
T17559 | 30328-30337 | NN | denotes | molecules |
T17558 | 30324-30327 | NN | denotes | RNA |
T17557 | 30314-30323 | JJ | denotes | noncoding |
T17556 | 30311-30313 | IN | denotes | of |
T17555 | 30305-30310 | NN | denotes | class |
T17554 | 30303-30304 | DT | denotes | a |
T17553 | 30293-30302 | VB | denotes | represent |
T17552 | 30289-30292 | CC | denotes | and |
T17551 | 30278-30288 | NN | denotes | expression |
T17550 | 30273-30277 | NN | denotes | gene |
T17549 | 30270-30272 | IN | denotes | of |
T17548 | 30259-30269 | NN | denotes | regulators |
T17547 | 30248-30258 | VB | denotes | discovered |
T17546 | 30239-30247 | RB | denotes | recently |
T17545 | 30235-30238 | VB | denotes | are |
T17544 | 30228-30234 | NN | denotes | miRNAs |
T17543 | 30218-30227 | NN | denotes | microRNAs |
T16673 | 30214-30215 | -RRB- | denotes | ] |
T16672 | 30212-30214 | CD | denotes | 76 |
T16671 | 30211-30212 | -LRB- | denotes | [ |
T16670 | 30208-30210 | NN | denotes | RA |
T16669 | 30203-30207 | IN | denotes | with |
T16668 | 30196-30202 | NN | denotes | region |
T16667 | 30190-30195 | NN | denotes | TRAF1 |
T16666 | 30186-30189 | DT | denotes | the |
T16665 | 30183-30185 | IN | denotes | of |
T16664 | 30171-30182 | NN | denotes | association |
T16663 | 30163-30170 | JJ | denotes | genetic |
T16662 | 30150-30162 | VB | denotes | demonstrates |
T16661 | 30145-30149 | RB | denotes | also |
T16660 | 30134-30144 | NN | denotes | population |
T16659 | 30127-30133 | JJ | denotes | Korean |
T16658 | 30125-30126 | DT | denotes | a |
T16657 | 30122-30124 | IN | denotes | in |
T16656 | 30117-30121 | NN | denotes | work |
T16655 | 30110-30116 | JJ | denotes | Recent |
T16654 | 30107-30108 | -RRB- | denotes | ] |
T16653 | 30105-30107 | CD | denotes | 75 |
T16652 | 30104-30105 | -LRB- | denotes | [ |
T16651 | 30098-30103 | NN | denotes | locus |
T16650 | 30088-30097 | JJ | denotes | causative |
T16649 | 30084-30087 | DT | denotes | the |
T16648 | 30081-30083 | VB | denotes | be |
T16647 | 30078-30080 | TO | denotes | to |
T16646 | 30071-30077 | JJ | denotes | likely |
T16645 | 30066-30070 | RB | denotes | more |
T16644 | 30063-30065 | VB | denotes | is |
T16643 | 30057-30062 | NN | denotes | TRAF1 |
T16625 | 29951-29954 | DT | denotes | the |
T16624 | 29948-29950 | IN | denotes | at |
T16623 | 29938-29947 | NN | denotes | variation |
T16622 | 29930-29937 | JJ | denotes | genetic |
T16621 | 29928-29929 | DT | denotes | a |
T16620 | 29917-29927 | VB | denotes | identified |
T16619 | 29908-29916 | NN | denotes | controls |
T16618 | 29902-29907 | CD | denotes | 1,800 |
T16617 | 29898-29901 | CC | denotes | and |
T16616 | 29892-29897 | NN | denotes | cases |
T16615 | 29889-29891 | NN | denotes | RA |
T16614 | 29867-29888 | JJ | denotes | autoantibody-positive |
T16613 | 29861-29866 | CD | denotes | 1,500 |
T16612 | 29847-29860 | RB | denotes | approximately |
T16611 | 29841-29846 | IN | denotes | among |
T16610 | 29836-29840 | NN | denotes | SNPs |
T16609 | 29828-29835 | CD | denotes | 300,000 |
T16608 | 29823-29827 | IN | denotes | than |
T16607 | 29818-29822 | JJ | denotes | more |
T16606 | 29808-29817 | VB | denotes | examining |
T16605 | 29802-29807 | NN | denotes | study |
T16604 | 29790-29801 | NN | denotes | association |
T16603 | 29778-29789 | JJ | denotes | genome-wide |
T16602 | 29776-29777 | DT | denotes | A |
T16601 | 29773-29774 | -RRB- | denotes | ] |
T16600 | 29771-29773 | CD | denotes | 73 |
T16599 | 29770-29771 | -LRB- | denotes | [ |
T16598 | 29761-29769 | VB | denotes | interact |
T16597 | 29750-29760 | RB | denotes | physically |
T16596 | 29746-29749 | MD | denotes | can |
T16595 | 29743-29745 | PRP | denotes | it |
T16594 | 29737-29742 | WDT | denotes | which |
T16593 | 29732-29736 | IN | denotes | with |
T16592 | 29728-29731 | NN | denotes | A20 |
T16591 | 29720-29727 | VB | denotes | recruit |
T16590 | 29714-29719 | MD | denotes | might |
T16589 | 29708-29713 | NN | denotes | TRAF1 |
T16588 | 29706-29707 | -COMMA- | denotes | , |
T16587 | 29693-29706 | RB | denotes | Alternatively |
T16586 | 29683-29691 | NN | denotes | proteins |
T16585 | 29672-29682 | NN | denotes | signalling |
T16584 | 29666-29671 | JJ | denotes | other |
T16583 | 29663-29665 | CC | denotes | or |
T16582 | 29654-29662 | NN | denotes | receptor |
T16581 | 29650-29653 | DT | denotes | the |
T16580 | 29647-29649 | TO | denotes | to |
T16579 | 29639-29646 | VB | denotes | binding |
T16578 | 29635-29638 | IN | denotes | for |
T16577 | 29627-29634 | NN | denotes | members |
T16576 | 29620-29626 | NN | denotes | family |
T16575 | 29615-29619 | NN | denotes | TRAF |
T16574 | 29610-29614 | IN | denotes | with |
T16573 | 29601-29609 | VB | denotes | competes |
T16572 | 29595-29600 | NN | denotes | TRAF1 |
T16571 | 29593-29594 | -COMMA- | denotes | , |
T16570 | 29585-29593 | RB | denotes | probably |
T16569 | 29580-29584 | RB | denotes | Most |
T16568 | 29571-29578 | JJ | denotes | unclear |
T16567 | 29565-29570 | RB | denotes | still |
T16566 | 29562-29564 | VB | denotes | is |
T16565 | 29551-29561 | NN | denotes | activation |
T16564 | 29548-29550 | NN | denotes | κB |
T16563 | 29544-29547 | NF- | denotes | NF- |
T16562 | 29534-29543 | VB | denotes | modulates |
T16561 | 29528-29533 | NN | denotes | TRAF1 |
T16560 | 29522-29527 | WDT | denotes | which |
T16559 | 29519-29521 | IN | denotes | by |
T16558 | 29509-29518 | NN | denotes | mechanism |
T16557 | 29505-29508 | DT | denotes | The |
T16556 | 29498-29503 | NN | denotes | cells |
T16555 | 29492-29497 | DT | denotes | these |
T16554 | 29489-29491 | IN | denotes | in |
T16553 | 29484-29488 | NN | denotes | role |
T16552 | 29473-29483 | JJ | denotes | regulatory |
T16551 | 29464-29472 | JJ | denotes | positive |
T16550 | 29462-29463 | DT | denotes | a |
T16549 | 29451-29461 | VB | denotes | suggesting |
T16548 | 29449-29450 | -COMMA- | denotes | , |
T16547 | 29442-29449 | NN | denotes | factors |
T16546 | 29426-29441 | JJ | denotes | TRAF2-dependent |
T16545 | 29423-29425 | IN | denotes | by |
T16544 | 29411-29422 | NN | denotes | stimulation |
T16543 | 29401-29410 | JJ | denotes | secondary |
T16542 | 29398-29400 | TO | denotes | to |
T16541 | 29388-29397 | NN | denotes | responses |
T16540 | 29377-29387 | VB | denotes | attenuated |
T16539 | 29372-29376 | VB | denotes | show |
T16538 | 29370-29371 | -COMMA- | denotes | , |
T16537 | 29363-29370 | RB | denotes | however |
T16536 | 29361-29362 | -COMMA- | denotes | , |
T16535 | 29356-29361 | NN | denotes | cells |
T16534 | 29346-29355 | JJ | denotes | dendritic |
T16533 | 29330-29345 | JJ | denotes | TRAF1-deficient |
T16532 | 29318-29328 | NN | denotes | activation |
T16531 | 29312-29317 | NN | denotes | NF-κB |
T16530 | 29299-29311 | JJ | denotes | CD40-induced |
T16529 | 29296-29298 | IN | denotes | of |
T16528 | 29286-29295 | NN | denotes | regulator |
T16527 | 29277-29285 | JJ | denotes | negative |
T16526 | 29275-29276 | DT | denotes | a |
T16525 | 29272-29274 | IN | denotes | as |
T16524 | 29262-29271 | VB | denotes | functions |
T16523 | 29257-29261 | RB | denotes | also |
T16522 | 29251-29256 | NN | denotes | TRAF1 |
T16521 | 29242-29249 | NN | denotes | pathway |
T16520 | 29231-29241 | NN | denotes | signalling |
T16519 | 29225-29230 | NN | denotes | NF-κB |
T16518 | 29221-29224 | DT | denotes | the |
T16517 | 29218-29220 | IN | denotes | of |
T16516 | 29207-29217 | NN | denotes | activation |
T16515 | 29203-29206 | CC | denotes | and |
T16514 | 29189-29202 | NN | denotes | proliferation |
T16513 | 29180-29188 | VB | denotes | enhanced |
T16512 | 29175-29179 | IN | denotes | with |
T16511 | 29173-29174 | -COMMA- | denotes | , |
T16510 | 29170-29173 | NN | denotes | TNF |
T16509 | 29167-29169 | TO | denotes | to |
T16508 | 29150-29166 | JJ | denotes | hyper-responsive |
T16507 | 29146-29149 | VB | denotes | are |
T16506 | 29140-29145 | NN | denotes | cells |
T16505 | 29138-29139 | NN | denotes | T |
T16504 | 29122-29137 | JJ | denotes | TRAF1-deficient |
T16503 | 29110-29120 | NN | denotes | activation |
T16502 | 29104-29109 | NN | denotes | NF-κB |
T16501 | 29092-29103 | JJ | denotes | TNF-induced |
T16500 | 29083-29091 | VB | denotes | inhibits |
T16499 | 29077-29082 | NN | denotes | TRAF1 |
T16498 | 29074-29076 | IN | denotes | of |
T16497 | 29059-29073 | NN | denotes | overexpression |
T16496 | 29055-29058 | CC | denotes | and |
T16495 | 29051-29054 | NN | denotes | TNF |
T16494 | 29048-29050 | IN | denotes | by |
T16493 | 29038-29047 | JJ | denotes | inducible |
T16492 | 29035-29037 | VB | denotes | is |
T16491 | 29029-29034 | NN | denotes | TRAF1 |
T16490 | 29026-29028 | IN | denotes | of |
T16489 | 29015-29025 | NN | denotes | Expression |
T16488 | 29012-29013 | -RRB- | denotes | ] |
T16487 | 29007-29012 | CD | denotes | 71,72 |
T16486 | 29006-29007 | -LRB- | denotes | [ |
T16485 | 28999-29005 | NN | denotes | manner |
T16484 | 28979-28998 | JJ | denotes | cell-type-dependent |
T16483 | 28977-28978 | DT | denotes | a |
T16482 | 28974-28976 | IN | denotes | in |
T16481 | 28965-28973 | RB | denotes | possibly |
T16480 | 28963-28964 | -COMMA- | denotes | , |
T16479 | 28954-28963 | NN | denotes | receptors |
T16478 | 28947-28953 | NN | denotes | family |
T16477 | 28943-28946 | NN | denotes | TNF |
T16476 | 28935-28942 | JJ | denotes | certain |
T16475 | 28932-28934 | IN | denotes | by |
T16474 | 28921-28931 | NN | denotes | signalling |
T16473 | 28915-28920 | NN | denotes | NF-κB |
T16472 | 28912-28914 | IN | denotes | of |
T16471 | 28902-28911 | NN | denotes | modulator |
T16470 | 28893-28901 | JJ | denotes | positive |
T16469 | 28891-28892 | DT | denotes | a |
T16468 | 28887-28890 | CC | denotes | and |
T16467 | 28878-28886 | JJ | denotes | negative |
T16466 | 28876-28877 | DT | denotes | a |
T16465 | 28871-28875 | CC | denotes | both |
T16464 | 28868-28870 | IN | denotes | as |
T16463 | 28862-28867 | NN | denotes | TRAF1 |
T16462 | 28858-28861 | IN | denotes | for |
T16461 | 28853-28857 | NN | denotes | role |
T16460 | 28851-28852 | DT | denotes | a |
T16459 | 28843-28850 | VB | denotes | support |
T16458 | 28838-28842 | NN | denotes | data |
T16457 | 28825-28837 | VB | denotes | Accumulating |
T16456 | 28815-28823 | NN | denotes | activity |
T16455 | 28808-28814 | NN | denotes | ligase |
T16454 | 28798-28807 | NN | denotes | ubiquitin |
T16453 | 28792-28797 | VB | denotes | lacks |
T16452 | 28782-28791 | RB | denotes | therefore |
T16451 | 28778-28781 | CC | denotes | and |
T16450 | 28771-28777 | NN | denotes | domain |
T16449 | 28764-28770 | NN | denotes | finger |
T16448 | 28759-28763 | NN | denotes | RING |
T16447 | 28757-28758 | DT | denotes | a |
T16446 | 28751-28756 | VB | denotes | lacks |
T16445 | 28748-28750 | PRP | denotes | it |
T16444 | 28740-28747 | IN | denotes | because |
T16443 | 28733-28739 | NN | denotes | family |
T16442 | 28725-28732 | NN | denotes | protein |
T16441 | 28720-28724 | NN | denotes | TRAF |
T16440 | 28716-28719 | DT | denotes | the |
T16439 | 28713-28715 | IN | denotes | of |
T16438 | 28706-28712 | NN | denotes | member |
T16437 | 28699-28705 | JJ | denotes | unique |
T16436 | 28697-28698 | DT | denotes | a |
T16435 | 28694-28696 | VB | denotes | is |
T16434 | 28688-28693 | NN | denotes | TRAF1 |
T16433 | 28686-28687 | CD | denotes | 1 |
T16432 | 28679-28685 | NN | denotes | factor |
T16431 | 28659-28678 | JJ | denotes | receptor-associated |
T16430 | 28655-28658 | NN | denotes | TNF |
T16642 | 30052-30056 | IN | denotes | that |
T16641 | 30042-30051 | VB | denotes | indicates |
T16640 | 30037-30041 | NN | denotes | work |
T16639 | 30026-30036 | JJ | denotes | Subsequent |
T16638 | 30023-30024 | -RRB- | denotes | ] |
T16637 | 30021-30023 | CD | denotes | 74 |
T16636 | 30020-30021 | -LRB- | denotes | [ |
T16635 | 30014-30019 | NN | denotes | locus |
T16634 | 30009-30013 | NN | denotes | risk |
T16633 | 30006-30008 | NN | denotes | RA |
T16632 | 29996-30005 | JJ | denotes | important |
T16631 | 29993-29995 | DT | denotes | an |
T16630 | 29990-29992 | IN | denotes | as |
T16629 | 29984-29989 | NN | denotes | locus |
T16628 | 29982-29983 | CD | denotes | 5 |
T16627 | 29972-29981 | NN | denotes | component |
T16626 | 29955-29971 | NN | denotes | TRAF1-complement |
T15641 | 27883-27890 | NN | denotes | pattern |
T15640 | 27872-27882 | NN | denotes | expression |
T15639 | 27861-27871 | JJ | denotes | restricted |
T15638 | 27856-27860 | RB | denotes | very |
T15637 | 27854-27855 | DT | denotes | a |
T15636 | 27850-27853 | VB | denotes | has |
T15635 | 27843-27849 | NN | denotes | SIGIRR |
T15634 | 27833-27841 | JJ | denotes | unlikely |
T15633 | 27829-27832 | RB | denotes | not |
T15632 | 27826-27828 | VB | denotes | is |
T15631 | 27823-27825 | NN | denotes | RA |
T15630 | 27820-27822 | IN | denotes | in |
T15629 | 27813-27819 | NN | denotes | SIGIRR |
T15628 | 27809-27812 | IN | denotes | for |
T15627 | 27804-27808 | NN | denotes | role |
T15626 | 27793-27803 | JJ | denotes | regulatory |
T15625 | 27791-27792 | DT | denotes | a |
T15624 | 27789-27790 | -COMMA- | denotes | , |
T15623 | 27788-27789 | -RRB- | denotes | ] |
T15622 | 27786-27788 | CD | denotes | 68 |
T15621 | 27785-27786 | -LRB- | denotes | [ |
T15620 | 27782-27784 | NN | denotes | RA |
T15619 | 27779-27781 | IN | denotes | in |
T15618 | 27770-27778 | VB | denotes | observed |
T15617 | 27757-27769 | NN | denotes | inflammation |
T15616 | 27749-27756 | JJ | denotes | chronic |
T15615 | 27745-27748 | DT | denotes | the |
T15614 | 27742-27744 | IN | denotes | in |
T15613 | 27731-27741 | NN | denotes | signalling |
T15612 | 27727-27730 | NN | denotes | TLR |
T15611 | 27723-27726 | CC | denotes | and |
T15610 | 27717-27722 | NN | denotes | IL-1R |
T15609 | 27714-27716 | IN | denotes | of |
T15608 | 27709-27713 | NN | denotes | role |
T15607 | 27699-27708 | JJ | denotes | important |
T15606 | 27695-27698 | DT | denotes | the |
T15605 | 27689-27694 | VB | denotes | Given |
T15604 | 27686-27687 | -RRB- | denotes | ) |
T15603 | 27685-27686 | CD | denotes | 1 |
T15602 | 27678-27684 | NN | denotes | Figure |
T15601 | 27677-27678 | -LRB- | denotes | ( |
T15600 | 27675-27676 | -RRB- | denotes | ] |
T15599 | 27673-27675 | CD | denotes | 67 |
T15598 | 27672-27673 | -LRB- | denotes | [ |
T15597 | 27666-27671 | NN | denotes | TRAF6 |
T15596 | 27663-27665 | CC | denotes | or |
T15595 | 27657-27662 | NN | denotes | IRAK1 |
T15594 | 27655-27656 | -COMMA- | denotes | , |
T15593 | 27650-27655 | NN | denotes | MyD88 |
T15592 | 27648-27649 | -COMMA- | denotes | , |
T15591 | 27639-27648 | NN | denotes | receptors |
T15590 | 27633-27638 | DT | denotes | these |
T15589 | 27628-27632 | IN | denotes | with |
T15588 | 27616-27627 | NN | denotes | interaction |
T15587 | 27609-27615 | JJ | denotes | direct |
T15586 | 27601-27608 | IN | denotes | through |
T15585 | 27592-27600 | RB | denotes | probably |
T15584 | 27590-27591 | -COMMA- | denotes | , |
T15583 | 27580-27590 | NN | denotes | signalling |
T15582 | 27576-27579 | NN | denotes | TLR |
T15581 | 27572-27575 | CC | denotes | and |
T15580 | 27566-27571 | NN | denotes | IL-1R |
T15579 | 27563-27565 | IN | denotes | of |
T15578 | 27553-27562 | NN | denotes | inhibitor |
T15577 | 27550-27552 | DT | denotes | an |
T15576 | 27547-27549 | IN | denotes | as |
T15575 | 27533-27546 | VB | denotes | characterised |
T15574 | 27521-27532 | RB | denotes | extensively |
T15573 | 27516-27520 | VB | denotes | been |
T15572 | 27512-27515 | VB | denotes | has |
T15571 | 27507-27511 | WDT | denotes | that |
T15570 | 27500-27506 | NN | denotes | family |
T15569 | 27490-27499 | NN | denotes | TLR/IL-1R |
T15568 | 27486-27489 | DT | denotes | the |
T15567 | 27483-27485 | IN | denotes | of |
T15566 | 27476-27482 | NN | denotes | member |
T15565 | 27474-27475 | DT | denotes | a |
T15564 | 27471-27473 | VB | denotes | is |
T15563 | 27469-27470 | -COMMA- | denotes | , |
T15562 | 27464-27469 | NN | denotes | TIR-8 |
T15561 | 27461-27463 | IN | denotes | as |
T15560 | 27455-27460 | VB | denotes | known |
T15559 | 27450-27454 | RB | denotes | also |
T15558 | 27448-27449 | -COMMA- | denotes | , |
T15557 | 27441-27448 | NN | denotes | protein |
T15556 | 27439-27440 | -RRB- | denotes | ) |
T15555 | 27433-27439 | NN | denotes | SIGIRR |
T15554 | 27432-27433 | -LRB- | denotes | ( |
T15553 | 27415-27431 | JJ | denotes | receptor-related |
T15552 | 27410-27414 | NN | denotes | IL-1 |
T15551 | 27388-27409 | JJ | denotes | Single-immunoglobulin |
T15550 | 27380-27387 | NN | denotes | protein |
T15549 | 27363-27379 | JJ | denotes | receptor-related |
T15547 | 27336-27357 | JJ | denotes | Single-immunoglobulin |
T15764 | 28650-28652 | NN | denotes | RA |
T15763 | 28647-28649 | IN | denotes | in |
T15762 | 28640-28646 | NN | denotes | target |
T15761 | 28628-28639 | JJ | denotes | therapeutic |
T15760 | 28616-28627 | JJ | denotes | interesting |
T15759 | 28613-28615 | DT | denotes | an |
T15758 | 28610-28612 | VB | denotes | be |
T15757 | 28605-28609 | RB | denotes | also |
T15756 | 28601-28604 | MD | denotes | may |
T15755 | 28594-28600 | NN | denotes | SIGIRR |
T15754 | 28592-28593 | -COMMA- | denotes | , |
T15753 | 28585-28592 | NN | denotes | pattern |
T15752 | 28574-28584 | NN | denotes | expression |
T15751 | 28563-28573 | JJ | denotes | restricted |
T15750 | 28559-28562 | PRP-DOLLAR- | denotes | its |
T15749 | 28556-28558 | IN | denotes | of |
T15748 | 28548-28555 | IN | denotes | Because |
T15747 | 28538-28546 | NN | denotes | patients |
T15746 | 28535-28537 | NN | denotes | RA |
T15745 | 28532-28534 | IN | denotes | in |
T15744 | 28520-28531 | VB | denotes | compromised |
T15743 | 28517-28519 | VB | denotes | is |
T15742 | 28510-28516 | NN | denotes | SIGIRR |
T15741 | 28507-28509 | IN | denotes | of |
T15740 | 28498-28506 | NN | denotes | function |
T15739 | 28494-28497 | DT | denotes | the |
T15738 | 28486-28493 | IN | denotes | whether |
T15737 | 28474-28485 | VB | denotes | investigate |
T15736 | 28471-28473 | TO | denotes | to |
T15735 | 28468-28470 | CC | denotes | or |
T15734 | 28466-28467 | -COMMA- | denotes | , |
T15733 | 28458-28466 | NN | denotes | patients |
T15732 | 28450-28457 | NN | denotes | control |
T15731 | 28447-28449 | IN | denotes | in |
T15730 | 28436-28446 | NN | denotes | expression |
T15729 | 28432-28435 | PRP-DOLLAR- | denotes | its |
T15728 | 28427-28431 | IN | denotes | with |
T15727 | 28418-28426 | NN | denotes | patients |
T15726 | 28415-28417 | NN | denotes | RA |
T15725 | 28412-28414 | IN | denotes | in |
T15724 | 28405-28411 | NN | denotes | SIGIRR |
T15723 | 28402-28404 | IN | denotes | of |
T15722 | 28391-28401 | NN | denotes | expression |
T15721 | 28387-28390 | DT | denotes | the |
T15720 | 28379-28386 | VB | denotes | compare |
T15719 | 28376-28378 | TO | denotes | to |
T15718 | 28364-28375 | JJ | denotes | interesting |
T15717 | 28361-28363 | VB | denotes | be |
T15716 | 28356-28360 | MD | denotes | will |
T15715 | 28353-28355 | PRP | denotes | It |
T15714 | 28350-28351 | -RRB- | denotes | ] |
T15713 | 28348-28350 | CD | denotes | 70 |
T15712 | 28347-28348 | -LRB- | denotes | [ |
T15711 | 28340-28346 | NN | denotes | models |
T15710 | 28334-28339 | NN | denotes | mouse |
T15709 | 28324-28333 | NN | denotes | arthritis |
T15708 | 28307-28323 | JJ | denotes | collagen-induced |
T15707 | 28304-28306 | IN | denotes | as |
T15706 | 28299-28303 | RB | denotes | well |
T15705 | 28296-28298 | RB | denotes | as |
T15704 | 28294-28295 | -COMMA- | denotes | , |
T15703 | 28285-28294 | NN | denotes | arthritis |
T15702 | 28269-28284 | JJ | denotes | zymosan-induced |
T15701 | 28266-28268 | IN | denotes | in |
T15700 | 28258-28265 | NN | denotes | disease |
T15699 | 28251-28257 | JJ | denotes | severe |
T15698 | 28246-28250 | RB | denotes | more |
T15697 | 28244-28245 | DT | denotes | a |
T15696 | 28234-28243 | VB | denotes | developed |
T15695 | 28229-28233 | NN | denotes | mice |
T15694 | 28212-28228 | JJ | denotes | SIGIRR-deficient |
T15693 | 28206-28211 | IN | denotes | since |
T15692 | 28204-28205 | -COMMA- | denotes | , |
T15691 | 28200-28204 | FW | denotes | vivo |
T15690 | 28197-28199 | FW | denotes | in |
T15689 | 28187-28196 | VB | denotes | confirmed |
T15688 | 28179-28186 | RB | denotes | further |
T15687 | 28175-28178 | VB | denotes | was |
T15686 | 28168-28174 | NN | denotes | SIGIRR |
T15685 | 28165-28167 | IN | denotes | of |
T15684 | 28156-28164 | NN | denotes | function |
T15683 | 28145-28155 | JJ | denotes | inhibitory |
T15682 | 28140-28144 | DT | denotes | This |
T15681 | 28133-28138 | NN | denotes | cells |
T15680 | 28124-28132 | JJ | denotes | synovial |
T15679 | 28121-28123 | NN | denotes | RA |
T15678 | 28115-28120 | JJ | denotes | human |
T15677 | 28112-28114 | IN | denotes | by |
T15676 | 28102-28111 | NN | denotes | cytokines |
T15675 | 28089-28101 | JJ | denotes | inflammatory |
T15674 | 28086-28088 | IN | denotes | of |
T15673 | 28078-28085 | NN | denotes | release |
T15672 | 28066-28077 | JJ | denotes | spontaneous |
T15671 | 28062-28065 | DT | denotes | the |
T15670 | 28054-28061 | VB | denotes | inhibit |
T15669 | 28051-28053 | TO | denotes | to |
T15668 | 28045-28050 | VB | denotes | shown |
T15667 | 28041-28044 | VB | denotes | was |
T15666 | 28026-28040 | NN | denotes | overexpression |
T15665 | 28019-28025 | NN | denotes | SIGIRR |
T15664 | 28017-28018 | -COMMA- | denotes | , |
T15663 | 28009-28017 | RB | denotes | Recently |
T15662 | 28006-28007 | -RRB- | denotes | ] |
T15661 | 28001-28006 | CD | denotes | 69,70 |
T15660 | 28000-28001 | -LRB- | denotes | [ |
T15659 | 27987-27999 | NN | denotes | macro-phages |
T15658 | 27980-27986 | JJ | denotes | mature |
T15657 | 27977-27979 | IN | denotes | in |
T15656 | 27973-27976 | RB | denotes | not |
T15655 | 27969-27972 | CC | denotes | but |
T15654 | 27967-27968 | -COMMA- | denotes | , |
T15653 | 27962-27967 | NN | denotes | cells |
T15652 | 27952-27961 | JJ | denotes | dendritic |
T15651 | 27943-27951 | JJ | denotes | immature |
T15650 | 27939-27942 | CC | denotes | and |
T15649 | 27929-27938 | NN | denotes | monocytes |
T15648 | 27927-27928 | -COMMA- | denotes | , |
T15647 | 27922-27927 | NN | denotes | cells |
T15646 | 27911-27921 | JJ | denotes | epithelial |
T15645 | 27908-27910 | IN | denotes | in |
T15644 | 27898-27907 | VB | denotes | expressed |
T15643 | 27892-27897 | VB | denotes | being |
T15642 | 27890-27891 | -COMMA- | denotes | , |
T14577 | 27331-27333 | NN | denotes | RA |
T14576 | 27328-27330 | IN | denotes | as |
T14575 | 27323-27327 | JJ | denotes | such |
T14574 | 27313-27322 | NN | denotes | disorders |
T14573 | 27308-27312 | NN | denotes | bone |
T14572 | 27305-27307 | IN | denotes | of |
T14571 | 27295-27304 | NN | denotes | pathology |
T14570 | 27291-27294 | DT | denotes | the |
T14569 | 27288-27290 | IN | denotes | in |
T14568 | 27279-27287 | VB | denotes | involved |
T14567 | 27272-27278 | NN | denotes | factor |
T14566 | 27264-27271 | JJ | denotes | genetic |
T14565 | 27254-27263 | JJ | denotes | potential |
T14564 | 27252-27253 | DT | denotes | a |
T14563 | 27249-27251 | IN | denotes | as |
T14562 | 27244-27248 | NN | denotes | CYLD |
T14561 | 27235-27243 | VB | denotes | indicate |
T14560 | 27231-27234 | CC | denotes | and |
T14559 | 27212-27230 | NN | denotes | osteoclastogenesis |
T14558 | 27209-27211 | IN | denotes | of |
T14557 | 27198-27208 | NN | denotes | regulation |
T14556 | 27189-27197 | JJ | denotes | negative |
T14555 | 27185-27188 | DT | denotes | the |
T14554 | 27182-27184 | IN | denotes | in |
T14553 | 27177-27181 | NN | denotes | role |
T14552 | 27173-27176 | JJ | denotes | key |
T14551 | 27171-27172 | DT | denotes | a |
T14550 | 27165-27170 | VB | denotes | plays |
T14549 | 27154-27164 | NN | denotes | signalling |
T14548 | 27148-27153 | NN | denotes | NF-κB |
T14547 | 27135-27147 | JJ | denotes | RANK-induced |
T14546 | 27132-27134 | IN | denotes | of |
T14545 | 27120-27131 | NN | denotes | inhibi-tion |
T14544 | 27106-27119 | JJ | denotes | CYLD-mediated |
T14543 | 27101-27105 | IN | denotes | that |
T14542 | 27093-27100 | VB | denotes | suggest |
T14541 | 27084-27092 | NN | denotes | findings |
T14540 | 27078-27083 | DT | denotes | These |
T14539 | 27075-27076 | -RRB- | denotes | ] |
T14538 | 27073-27075 | CD | denotes | 66 |
T14537 | 27072-27073 | -LRB- | denotes | [ |
T14536 | 27067-27071 | NN | denotes | loss |
T14535 | 27062-27066 | NN | denotes | bone |
T14534 | 27050-27061 | JJ | denotes | progressive |
T14533 | 27042-27049 | VB | denotes | develop |
T14532 | 27038-27041 | CC | denotes | and |
T14531 | 27019-27037 | NN | denotes | osteoclastogenesis |
T14530 | 27010-27018 | JJ | denotes | abnormal |
T14529 | 27002-27009 | VB | denotes | display |
T14528 | 26997-27001 | RB | denotes | also |
T14527 | 26993-26996 | NN | denotes | p62 |
T14526 | 26990-26992 | IN | denotes | of |
T14525 | 26985-26989 | NN | denotes | form |
T14524 | 26977-26984 | VB | denotes | mutated |
T14523 | 26975-26976 | DT | denotes | a |
T14522 | 26964-26974 | VB | denotes | expressing |
T14521 | 26959-26963 | NN | denotes | mice |
T14520 | 26948-26958 | JJ | denotes | transgenic |
T14519 | 26943-26947 | IN | denotes | that |
T14518 | 26932-26942 | VB | denotes | mentioning |
T14517 | 26926-26931 | JJ | denotes | worth |
T14516 | 26923-26925 | VB | denotes | is |
T14515 | 26920-26922 | PRP | denotes | it |
T14514 | 26918-26919 | -COMMA- | denotes | , |
T14513 | 26911-26918 | NN | denotes | context |
T14512 | 26906-26910 | DT | denotes | this |
T14511 | 26903-26905 | IN | denotes | In |
T14510 | 26896-26901 | NN | denotes | TRAF6 |
T14509 | 26893-26895 | IN | denotes | of |
T14508 | 26876-26892 | NN | denotes | deubiquitination |
T14507 | 26862-26875 | JJ | denotes | CYLD-mediated |
T14506 | 26858-26861 | DT | denotes | the |
T14505 | 26855-26857 | IN | denotes | by |
T14504 | 26846-26854 | VB | denotes | followed |
T14503 | 26844-26845 | -COMMA- | denotes | , |
T14502 | 26843-26844 | -RRB- | denotes | ] |
T14501 | 26841-26843 | CD | denotes | 65 |
T14500 | 26840-26841 | -LRB- | denotes | [ |
T14499 | 26838-26839 | -RRB- | denotes | ) |
T14498 | 26837-26838 | CD | denotes | 1 |
T14497 | 26824-26836 | NN | denotes | sequestosome |
T14496 | 26821-26823 | IN | denotes | as |
T14495 | 26815-26820 | VB | denotes | known |
T14494 | 26810-26814 | RB | denotes | also |
T14493 | 26809-26810 | -LRB- | denotes | ( |
T14492 | 26805-26808 | NN | denotes | p62 |
T14491 | 26797-26804 | NN | denotes | protein |
T14490 | 26789-26796 | NN | denotes | adaptor |
T14489 | 26771-26788 | JJ | denotes | ubiquitin-binding |
T14488 | 26767-26770 | DT | denotes | the |
T14487 | 26763-26766 | IN | denotes | via |
T14486 | 26757-26762 | NN | denotes | TRAF6 |
T14485 | 26743-26756 | VB | denotes | ubiquitinated |
T14484 | 26740-26742 | TO | denotes | to |
T14483 | 26730-26739 | VB | denotes | recruited |
T14482 | 26727-26729 | VB | denotes | is |
T14481 | 26723-26726 | CC | denotes | and |
T14480 | 26704-26722 | NN | denotes | osteoclastogenesis |
T14479 | 26690-26703 | JJ | denotes | RANKL-induced |
T14478 | 26687-26689 | IN | denotes | of |
T14477 | 26676-26686 | NN | denotes | conditions |
T14476 | 26670-26675 | IN | denotes | under |
T14475 | 26658-26669 | VB | denotes | upregulated |
T14474 | 26649-26657 | RB | denotes | markedly |
T14473 | 26646-26648 | VB | denotes | is |
T14472 | 26635-26645 | NN | denotes | expression |
T14471 | 26630-26634 | NN | denotes | CYLD |
T14470 | 26617-26628 | NN | denotes | osteoclasts |
T14469 | 26610-26616 | JJ | denotes | larger |
T14468 | 26606-26609 | CC | denotes | and |
T14467 | 26601-26605 | JJ | denotes | more |
T14466 | 26593-26600 | VB | denotes | produce |
T14465 | 26589-26592 | CC | denotes | and |
T14464 | 26573-26588 | NN | denotes | differentiation |
T14463 | 26559-26572 | JJ | denotes | RANKL-induced |
T14462 | 26556-26558 | TO | denotes | to |
T14461 | 26539-26555 | JJ | denotes | hyper-responsive |
T14460 | 26535-26538 | VB | denotes | are |
T14459 | 26530-26534 | NN | denotes | mice |
T14458 | 26524-26529 | DT | denotes | these |
T14457 | 26521-26523 | IN | denotes | of |
T14456 | 26510-26520 | NN | denotes | precursors |
T14455 | 26499-26509 | NN | denotes | Osteoclast |
T14454 | 26485-26497 | NN | denotes | osteoporosis |
T14453 | 26478-26484 | JJ | denotes | severe |
T14452 | 26470-26477 | VB | denotes | develop |
T14451 | 26466-26469 | CC | denotes | and |
T14450 | 26450-26465 | NN | denotes | differentiation |
T14449 | 26439-26449 | NN | denotes | osteoclast |
T14448 | 26430-26438 | JJ | denotes | aberrant |
T14447 | 26425-26429 | VB | denotes | have |
T14446 | 26420-26424 | NN | denotes | CYLD |
T14445 | 26417-26419 | IN | denotes | of |
T14444 | 26406-26416 | NN | denotes | deficiency |
T14443 | 26398-26405 | JJ | denotes | genetic |
T14442 | 26396-26397 | DT | denotes | a |
T14441 | 26391-26395 | IN | denotes | with |
T14440 | 26386-26390 | NN | denotes | Mice |
T14439 | 26383-26384 | -RRB- | denotes | ] |
T14438 | 26381-26383 | CD | denotes | 65 |
T14437 | 26380-26381 | -LRB- | denotes | [ |
T14436 | 26375-26379 | NN | denotes | mice |
T14435 | 26372-26374 | IN | denotes | in |
T14434 | 26353-26371 | NN | denotes | osteoclastogenesis |
T14433 | 26349-26352 | CC | denotes | and |
T14432 | 26338-26348 | NN | denotes | signalling |
T14431 | 26333-26337 | NN | denotes | RANK |
T14430 | 26324-26332 | VB | denotes | regulate |
T14429 | 26313-26323 | RB | denotes | negatively |
T14428 | 26310-26312 | TO | denotes | to |
T14427 | 26304-26309 | VB | denotes | shown |
T14426 | 26299-26303 | VB | denotes | been |
T14425 | 26295-26298 | VB | denotes | has |
T14424 | 26290-26294 | NN | denotes | CYLD |
T14423 | 26288-26289 | -COMMA- | denotes | , |
T14422 | 26275-26288 | RB | denotes | Interestingly |
T14421 | 26272-26273 | -RRB- | denotes | ] |
T14420 | 26270-26272 | CD | denotes | 64 |
T14419 | 26269-26270 | -LRB- | denotes | [ |
T14418 | 26259-26268 | JJ | denotes | dependent |
T14417 | 26249-26258 | JJ | denotes | cell-type |
T14416 | 26246-26248 | VB | denotes | be |
T14415 | 26241-26245 | RB | denotes | also |
T14414 | 26235-26240 | MD | denotes | might |
T14413 | 26226-26234 | NN | denotes | activity |
T14265 | 25385-25389 | NN | denotes | CYLD |
T14264 | 25382-25383 | -RRB- | denotes | ] |
T14263 | 25380-25382 | CD | denotes | 63 |
T14262 | 25379-25380 | -LRB- | denotes | [ |
T14261 | 25363-25378 | NN | denotes | cylindromatosis |
T14260 | 25354-25362 | JJ | denotes | familial |
T14259 | 25351-25353 | IN | denotes | in |
T14258 | 25342-25350 | VB | denotes | involved |
T14257 | 25331-25341 | NN | denotes | suppressor |
T14256 | 25324-25330 | NN | denotes | tumour |
T14255 | 25322-25323 | DT | denotes | a |
T14254 | 25319-25321 | IN | denotes | as |
T14253 | 25308-25318 | VB | denotes | identified |
T14252 | 25297-25307 | RB | denotes | originally |
T14251 | 25293-25296 | VB | denotes | was |
T14250 | 25285-25292 | NN | denotes | protein |
T14249 | 25283-25284 | -RRB- | denotes | ) |
T14248 | 25279-25283 | NN | denotes | CYLD |
T14247 | 25278-25279 | -LRB- | denotes | ( |
T14246 | 25262-25277 | NN | denotes | Cylindromatosis |
T14245 | 25254-25261 | NN | denotes | protein |
T14244 | 25238-25253 | NN | denotes | Cylindromatosis |
T14412 | 26217-26225 | JJ | denotes | relative |
T14411 | 26211-26216 | PRP-DOLLAR- | denotes | their |
T14410 | 26209-26210 | -COMMA- | denotes | , |
T14409 | 26201-26209 | NN | denotes | addition |
T14408 | 26198-26200 | IN | denotes | In |
T14407 | 26186-26196 | NN | denotes | signalling |
T14406 | 26180-26185 | JJ | denotes | early |
T14405 | 26176-26179 | CC | denotes | and |
T14404 | 26163-26175 | JJ | denotes | constitutive |
T14403 | 26154-26162 | VB | denotes | regulate |
T14402 | 26148-26153 | MD | denotes | would |
T14401 | 26143-26147 | NN | denotes | CYLD |
T14400 | 26135-26142 | IN | denotes | whereas |
T14399 | 26133-26134 | -COMMA- | denotes | , |
T14398 | 26123-26133 | NN | denotes | signalling |
T14397 | 26117-26122 | NN | denotes | NF-κB |
T14396 | 26114-26116 | IN | denotes | of |
T14395 | 26107-26113 | NN | denotes | phases |
T14394 | 26101-26106 | JJ | denotes | later |
T14393 | 26091-26100 | VB | denotes | regulates |
T14392 | 26084-26090 | RB | denotes | mainly |
T14391 | 26076-26083 | NN | denotes | protein |
T14390 | 26071-26075 | DT | denotes | this |
T14389 | 26066-26070 | IN | denotes | that |
T14388 | 26056-26065 | VB | denotes | suggested |
T14387 | 26051-26055 | VB | denotes | been |
T14386 | 26047-26050 | VB | denotes | has |
T14385 | 26044-26046 | PRP | denotes | it |
T14384 | 26042-26043 | -COMMA- | denotes | , |
T14383 | 26031-26042 | NN | denotes | stimulation |
T14382 | 26026-26030 | IN | denotes | upon |
T14381 | 26020-26025 | NN | denotes | types |
T14380 | 26015-26019 | NN | denotes | cell |
T14379 | 26010-26014 | JJ | denotes | many |
T14378 | 26007-26009 | IN | denotes | in |
T14377 | 25997-26006 | VB | denotes | expressed |
T14376 | 25992-25996 | RB | denotes | only |
T14375 | 25989-25991 | VB | denotes | is |
T14374 | 25985-25988 | NN | denotes | A20 |
T14373 | 25982-25984 | IN | denotes | As |
T14372 | 25970-25980 | NN | denotes | activation |
T14371 | 25964-25969 | NN | denotes | NF-κB |
T14370 | 25956-25963 | VB | denotes | control |
T14369 | 25953-25955 | TO | denotes | to |
T14368 | 25948-25952 | NN | denotes | CYLD |
T14367 | 25945-25947 | IN | denotes | as |
T14366 | 25940-25944 | RB | denotes | well |
T14365 | 25937-25939 | RB | denotes | as |
T14364 | 25933-25936 | NN | denotes | A20 |
T14363 | 25927-25932 | VB | denotes | needs |
T14362 | 25922-25926 | NN | denotes | cell |
T14361 | 25918-25921 | DT | denotes | the |
T14360 | 25914-25917 | WRB | denotes | why |
T14359 | 25908-25913 | JJ | denotes | clear |
T14358 | 25904-25907 | RB | denotes | not |
T14357 | 25898-25903 | RB | denotes | still |
T14356 | 25895-25897 | VB | denotes | is |
T14355 | 25892-25894 | PRP | denotes | it |
T14354 | 25888-25891 | CC | denotes | and |
T14353 | 25884-25887 | NN | denotes | A20 |
T14352 | 25881-25883 | IN | denotes | by |
T14351 | 25872-25880 | VB | denotes | targeted |
T14350 | 25867-25871 | RB | denotes | also |
T14349 | 25863-25866 | VB | denotes | are |
T14348 | 25857-25862 | DT | denotes | these |
T14347 | 25854-25856 | IN | denotes | of |
T14346 | 25849-25853 | JJ | denotes | Many |
T14345 | 25843-25847 | NN | denotes | TAK1 |
T14344 | 25839-25842 | CC | denotes | and |
T14343 | 25834-25838 | NN | denotes | RIP1 |
T14342 | 25832-25833 | -COMMA- | denotes | , |
T14341 | 25827-25832 | NN | denotes | TRAF7 |
T14340 | 25825-25826 | -COMMA- | denotes | , |
T14339 | 25820-25825 | NN | denotes | TRAF6 |
T14338 | 25818-25819 | -COMMA- | denotes | , |
T14337 | 25813-25818 | NN | denotes | TRAF2 |
T14336 | 25811-25812 | -COMMA- | denotes | , |
T14335 | 25807-25811 | NN | denotes | NEMO |
T14334 | 25797-25806 | VB | denotes | including |
T14333 | 25788-25796 | NN | denotes | proteins |
T14332 | 25777-25787 | NN | denotes | signalling |
T14331 | 25771-25776 | NN | denotes | NF-κB |
T14330 | 25763-25770 | JJ | denotes | several |
T14329 | 25745-25762 | JJ | denotes | deubiquitina-ting |
T14328 | 25742-25744 | IN | denotes | by |
T14327 | 25740-25741 | -COMMA- | denotes | , |
T14326 | 25739-25740 | -RRB- | denotes | ) |
T14325 | 25738-25739 | CD | denotes | 1 |
T14324 | 25731-25737 | NN | denotes | Figure |
T14323 | 25730-25731 | -LRB- | denotes | ( |
T14322 | 25728-25729 | -RRB- | denotes | ) |
T14321 | 25727-25728 | -RRB- | denotes | ] |
T14320 | 25725-25727 | CD | denotes | 64 |
T14319 | 25724-25725 | -LRB- | denotes | [ |
T14318 | 25721-25723 | IN | denotes | in |
T14317 | 25712-25720 | VB | denotes | reviewed |
T14316 | 25711-25712 | -LRB- | denotes | ( |
T14315 | 25699-25710 | NN | denotes | stimulation |
T14314 | 25690-25698 | NN | denotes | receptor |
T14313 | 25683-25689 | NN | denotes | T-cell |
T14312 | 25679-25682 | CC | denotes | and |
T14311 | 25674-25678 | NN | denotes | RANK |
T14310 | 25672-25673 | -COMMA- | denotes | , |
T14309 | 25668-25672 | NN | denotes | TNFR |
T14308 | 25665-25667 | IN | denotes | by |
T14307 | 25655-25664 | VB | denotes | initiated |
T14306 | 25644-25654 | NN | denotes | signalling |
T14305 | 25638-25643 | NN | denotes | NF-κB |
T14304 | 25628-25637 | VB | denotes | regulates |
T14303 | 25617-25627 | RB | denotes | negatively |
T14302 | 25612-25616 | WDT | denotes | that |
T14301 | 25605-25611 | NN | denotes | enzyme |
T14300 | 25588-25604 | VB | denotes | deubiquitinating |
T14299 | 25586-25587 | DT | denotes | a |
T14298 | 25583-25585 | VB | denotes | is |
T14297 | 25578-25582 | NN | denotes | CYLD |
T14296 | 25575-25576 | -RRB- | denotes | ) |
T14295 | 25574-25575 | -RRB- | denotes | ] |
T14294 | 25572-25574 | CD | denotes | 64 |
T14293 | 25571-25572 | -LRB- | denotes | [ |
T14292 | 25568-25570 | IN | denotes | in |
T14291 | 25559-25567 | VB | denotes | reviewed |
T14290 | 25558-25559 | -LRB- | denotes | ( |
T14289 | 25539-25557 | NN | denotes | osteoclastogenesis |
T14288 | 25535-25538 | CC | denotes | and |
T14287 | 25533-25534 | -COMMA- | denotes | , |
T14286 | 25518-25533 | NN | denotes | spermatogenesis |
T14285 | 25516-25517 | -COMMA- | denotes | , |
T14284 | 25505-25516 | NN | denotes | progression |
T14283 | 25499-25504 | NN | denotes | cycle |
T14282 | 25494-25498 | NN | denotes | cell |
T14281 | 25491-25493 | TO | denotes | to |
T14280 | 25478-25490 | NN | denotes | inflammation |
T14279 | 25474-25477 | CC | denotes | and |
T14278 | 25465-25473 | NN | denotes | immunity |
T14277 | 25460-25464 | IN | denotes | from |
T14276 | 25452-25459 | VB | denotes | ranging |
T14275 | 25442-25451 | NN | denotes | processes |
T14274 | 25428-25441 | JJ | denotes | physiological |
T14273 | 25420-25427 | JJ | denotes | diverse |
T14272 | 25417-25419 | IN | denotes | in |
T14271 | 25415-25416 | -COMMA- | denotes | , |
T14270 | 25408-25415 | RB | denotes | however |
T14269 | 25406-25407 | -COMMA- | denotes | , |
T14268 | 25398-25406 | VB | denotes | involved |
T14267 | 25393-25397 | RB | denotes | also |
T14266 | 25390-25392 | VB | denotes | is |
T13114 | 25233-25235 | NN | denotes | RA |
T13113 | 25228-25232 | IN | denotes | with |
T13112 | 25217-25227 | VB | denotes | associated |
T13111 | 25212-25216 | RB | denotes | also |
T13110 | 25208-25211 | VB | denotes | are |
T13109 | 25194-25207 | NN | denotes | erythematosus |
T13108 | 25188-25193 | NN | denotes | lupus |
T13107 | 25179-25187 | JJ | denotes | systemic |
T13106 | 25174-25178 | IN | denotes | with |
T13105 | 25163-25173 | VB | denotes | associated |
T13104 | 25160-25162 | VB | denotes | be |
T13103 | 25157-25159 | TO | denotes | to |
T13102 | 25148-25156 | VB | denotes | reported |
T13101 | 25143-25147 | VB | denotes | been |
T13100 | 25138-25142 | VB | denotes | have |
T13099 | 25133-25137 | WDT | denotes | that |
T13098 | 25128-25132 | NN | denotes | SNPs |
T13097 | 25120-25127 | IN | denotes | whether |
T13096 | 25108-25119 | VB | denotes | investigate |
T13095 | 25105-25107 | TO | denotes | to |
T13094 | 25093-25104 | JJ | denotes | interesting |
T13093 | 25090-25092 | VB | denotes | be |
T13092 | 25080-25089 | RB | denotes | therefore |
T13091 | 25075-25079 | MD | denotes | will |
T13090 | 25072-25074 | PRP | denotes | It |
T13089 | 25069-25070 | -RRB- | denotes | ) |
T13088 | 25060-25069 | NN | denotes | rituximab |
T13087 | 25059-25060 | -LRB- | denotes | ( |
T13086 | 25049-25058 | NN | denotes | depletion |
T13085 | 25042-25048 | NN | denotes | B-cell |
T13084 | 25039-25041 | IN | denotes | as |
T13083 | 25034-25038 | JJ | denotes | such |
T13082 | 25023-25033 | NN | denotes | treatments |
T13081 | 25020-25022 | TO | denotes | to |
T13080 | 25011-25019 | NN | denotes | response |
T13079 | 25007-25010 | CC | denotes | and |
T13078 | 24998-25006 | NN | denotes | features |
T13077 | 24989-24997 | JJ | denotes | systemic |
T13076 | 24987-24988 | -COMMA- | denotes | , |
T13075 | 24977-24987 | NN | denotes | production |
T13074 | 24964-24976 | NN | denotes | autoantibody |
T13073 | 24962-24963 | -COMMA- | denotes | , |
T13072 | 24951-24962 | NN | denotes | involvement |
T13071 | 24945-24950 | JJ | denotes | joint |
T13070 | 24942-24944 | IN | denotes | in |
T13069 | 24934-24941 | NN | denotes | overlap |
T13068 | 24925-24933 | JJ | denotes | clinical |
T13067 | 24920-24924 | DT | denotes | some |
T13066 | 24915-24919 | VB | denotes | show |
T13065 | 24906-24914 | NN | denotes | diseases |
T13064 | 24902-24905 | CD | denotes | two |
T13063 | 24898-24901 | DT | denotes | the |
T13062 | 24895-24897 | IN | denotes | as |
T13061 | 24886-24894 | VB | denotes | expected |
T13060 | 24883-24885 | VB | denotes | be |
T13059 | 24877-24882 | MD | denotes | might |
T13058 | 24872-24876 | NN | denotes | loci |
T13057 | 24857-24871 | NN | denotes | susceptibility |
T13056 | 24854-24856 | NN | denotes | RA |
T13055 | 24850-24853 | CC | denotes | and |
T13054 | 24836-24849 | NN | denotes | erythematosus |
T13053 | 24830-24835 | NN | denotes | lupus |
T13052 | 24821-24829 | JJ | denotes | systemic |
T13051 | 24813-24820 | IN | denotes | between |
T13050 | 24805-24812 | NN | denotes | overlap |
T13049 | 24802-24804 | IN | denotes | of |
T13048 | 24795-24801 | NN | denotes | degree |
T13047 | 24790-24794 | JJ | denotes | high |
T13046 | 24788-24789 | DT | denotes | A |
T13045 | 24785-24786 | -RRB- | denotes | ] |
T13044 | 24780-24785 | CD | denotes | 61,62 |
T13043 | 24779-24780 | -LRB- | denotes | [ |
T13042 | 24772-24778 | NN | denotes | humans |
T13041 | 24769-24771 | IN | denotes | in |
T13040 | 24755-24768 | NN | denotes | erythematosus |
T13039 | 24749-24754 | NN | denotes | lupus |
T13038 | 24740-24748 | JJ | denotes | systemic |
T13037 | 24736-24739 | CC | denotes | and |
T13036 | 24726-24735 | NN | denotes | psoriasis |
T13035 | 24721-24725 | IN | denotes | with |
T13034 | 24710-24720 | VB | denotes | associated |
T13033 | 24705-24709 | VB | denotes | been |
T13032 | 24700-24704 | VB | denotes | have |
T13031 | 24686-24699 | NN | denotes | polymorphisms |
T13030 | 24679-24685 | NN | denotes | ABIN-1 |
T13029 | 24677-24678 | -COMMA- | denotes | , |
T13028 | 24664-24677 | RB | denotes | Interestingly |
T13027 | 24661-24662 | -RRB- | denotes | ] |
T13026 | 24659-24661 | CD | denotes | 60 |
T13025 | 24658-24659 | -LRB- | denotes | [ |
T13024 | 24646-24657 | NN | denotes | macrophages |
T13023 | 24637-24645 | JJ | denotes | synovial |
T13022 | 24627-24636 | NN | denotes | arthritis |
T13021 | 24614-24626 | JJ | denotes | inflammatory |
T13020 | 24611-24613 | IN | denotes | in |
T13019 | 24600-24610 | VB | denotes | suppressed |
T13018 | 24591-24599 | RB | denotes | strongly |
T13017 | 24587-24590 | VB | denotes | was |
T13016 | 24582-24586 | NNP | denotes | ITAM |
T13015 | 24578-24581 | DT | denotes | the |
T13014 | 24575-24577 | IN | denotes | of |
T13013 | 24568-24574 | NN | denotes | effect |
T13012 | 24557-24567 | JJ | denotes | protective |
T13011 | 24552-24556 | DT | denotes | this |
T13010 | 24550-24551 | -COMMA- | denotes | , |
T13009 | 24542-24550 | RB | denotes | Moreover |
T13008 | 24537-24540 | NN | denotes | A20 |
T13007 | 24533-24536 | CC | denotes | and |
T13006 | 24526-24532 | NN | denotes | ABIN-3 |
T13005 | 24517-24525 | NN | denotes | proteins |
T13004 | 24506-24516 | JJ | denotes | inhibitory |
T13003 | 24500-24505 | NN | denotes | NF-κB |
T13002 | 24496-24499 | DT | denotes | the |
T13001 | 24493-24495 | IN | denotes | of |
T13000 | 24482-24492 | NN | denotes | expression |
T12999 | 24478-24481 | DT | denotes | the |
T12998 | 24475-24477 | IN | denotes | on |
T12997 | 24468-24474 | VB | denotes | depend |
T12996 | 24465-24467 | TO | denotes | to |
T12995 | 24459-24464 | VB | denotes | shown |
T12994 | 24455-24458 | VB | denotes | was |
T12993 | 24445-24454 | NN | denotes | receptors |
T12992 | 24436-24444 | JJ | denotes | -coupled |
T12991 | 24435-24436 | -RRB- | denotes | ) |
T12990 | 24431-24435 | NN | denotes | ITAM |
T12989 | 24430-24431 | -LRB- | denotes | ( |
T12988 | 24424-24429 | NN | denotes | motif |
T12987 | 24413-24423 | NN | denotes | activation |
T12986 | 24398-24412 | JJ | denotes | tyrosine-based |
T12985 | 24383-24397 | NN | denotes | immunoreceptor |
T12984 | 24380-24382 | IN | denotes | by |
T12983 | 24370-24379 | NN | denotes | responses |
T12982 | 24366-24369 | NN | denotes | TLR |
T12981 | 24363-24365 | IN | denotes | of |
T12980 | 24352-24362 | NN | denotes | inhibition |
T12979 | 24350-24351 | -COMMA- | denotes | , |
T12978 | 24345-24350 | NN | denotes | study |
T12977 | 24338-24344 | JJ | denotes | recent |
T12976 | 24336-24337 | DT | denotes | a |
T12975 | 24333-24335 | IN | denotes | In |
T12974 | 24330-24331 | -RRB- | denotes | ] |
T12973 | 24328-24330 | CD | denotes | 59 |
T12972 | 24327-24328 | -LRB- | denotes | [ |
T12971 | 24324-24326 | NN | denotes | RA |
T12970 | 24321-24323 | IN | denotes | of |
T12969 | 24308-24320 | NN | denotes | pathogenesis |
T12968 | 24304-24307 | DT | denotes | the |
T12967 | 24300-24303 | CC | denotes | and |
T12966 | 24289-24299 | NN | denotes | signalling |
T12965 | 24283-24288 | NN | denotes | NF-κB |
T12964 | 24280-24282 | IN | denotes | of |
T12963 | 24269-24279 | NN | denotes | regulation |
T12962 | 24260-24268 | NN | denotes | feedback |
T12961 | 24251-24259 | JJ | denotes | negative |
T12960 | 24247-24250 | DT | denotes | the |
T12959 | 24244-24246 | IN | denotes | in |
T12958 | 24242-24243 | -COMMA- | denotes | , |
T12957 | 24239-24242 | NN | denotes | A20 |
T12956 | 24234-24238 | IN | denotes | with |
T12955 | 24225-24233 | RB | denotes | together |
T12954 | 24223-24224 | -COMMA- | denotes | , |
T12953 | 24217-24223 | NN | denotes | ABIN-1 |
T12952 | 24213-24216 | IN | denotes | for |
T12951 | 24208-24212 | NN | denotes | role |
T12950 | 24198-24207 | JJ | denotes | potential |
T12949 | 24196-24197 | DT | denotes | a |
T12948 | 24185-24195 | VB | denotes | indicating |
T12947 | 24183-24184 | -COMMA- | denotes | , |
T12946 | 24175-24183 | NN | denotes | biopsies |
T12945 | 24168-24174 | NN | denotes | tissue |
T12944 | 24165-24167 | NN | denotes | RA |
T12943 | 24162-24164 | IN | denotes | in |
T12942 | 24153-24161 | VB | denotes | detected |
T12753 | 22953-22954 | -COMMA- | denotes | , |
T12752 | 22947-22953 | NN | denotes | TNIP-2 |
T12751 | 22945-22946 | -COMMA- | denotes | , |
T12750 | 22939-22945 | NN | denotes | TNIP-1 |
T12749 | 22936-22938 | IN | denotes | as |
T12748 | 22930-22935 | VB | denotes | known |
T12747 | 22925-22929 | RB | denotes | also |
T12746 | 22924-22925 | -LRB- | denotes | ( |
T12745 | 22917-22923 | NN | denotes | ABIN-3 |
T12744 | 22913-22916 | CC | denotes | and |
T12743 | 22906-22912 | NN | denotes | ABIN-2 |
T12742 | 22904-22905 | -COMMA- | denotes | , |
T12741 | 22898-22904 | NN | denotes | ABIN-1 |
T12740 | 22892-22897 | NN | denotes | NF-κB |
T12739 | 22889-22891 | IN | denotes | of |
T12738 | 22878-22888 | NN | denotes | inhibitors |
T12737 | 22866-22877 | JJ | denotes | A20-binding |
T12941 | 24148-24152 | VB | denotes | were |
T12940 | 24143-24147 | NN | denotes | mRNA |
T12939 | 24136-24142 | NN | denotes | ABIN-1 |
T12938 | 24133-24135 | IN | denotes | of |
T12937 | 24126-24132 | NN | denotes | levels |
T12936 | 24121-24125 | JJ | denotes | high |
T12935 | 24117-24120 | CC | denotes | and |
T12934 | 24115-24116 | -COMMA- | denotes | , |
T12933 | 24103-24115 | NN | denotes | synoviocytes |
T12932 | 24097-24102 | JJ | denotes | human |
T12931 | 24094-24096 | IN | denotes | in |
T12930 | 24088-24093 | NN | denotes | genes |
T12929 | 24076-24087 | JJ | denotes | TNF-induced |
T12928 | 24070-24075 | IN | denotes | among |
T12927 | 24059-24069 | VB | denotes | identified |
T12926 | 24055-24058 | VB | denotes | was |
T12925 | 24048-24054 | NN | denotes | ABIN-1 |
T12924 | 24046-24047 | -COMMA- | denotes | , |
T12923 | 24038-24046 | NN | denotes | analysis |
T12922 | 24027-24037 | NN | denotes | microarray |
T12921 | 24011-24026 | NN | denotes | oligonucleotide |
T12920 | 24005-24010 | VB | denotes | Using |
T12919 | 24002-24003 | -RRB- | denotes | ] |
T12918 | 24000-24002 | CD | denotes | 56 |
T12917 | 23999-24000 | -LRB- | denotes | [ |
T12916 | 23989-23998 | NN | denotes | apoptosis |
T12915 | 23983-23988 | NN | denotes | liver |
T12914 | 23976-23982 | JJ | denotes | foetal |
T12913 | 23962-23975 | JJ | denotes | TNF-dependent |
T12912 | 23959-23961 | TO | denotes | to |
T12911 | 23955-23958 | JJ | denotes | due |
T12910 | 23941-23954 | RB | denotes | embryonically |
T12909 | 23937-23940 | VB | denotes | die |
T12908 | 23932-23936 | NN | denotes | mice |
T12907 | 23922-23931 | JJ | denotes | deficient |
T12906 | 23915-23921 | NN | denotes | ABIN-1 |
T12905 | 23911-23914 | CC | denotes | and |
T12904 | 23909-23910 | -COMMA- | denotes | , |
T12903 | 23908-23909 | -RRB- | denotes | ] |
T12902 | 23906-23908 | CD | denotes | 58 |
T12901 | 23905-23906 | -LRB- | denotes | [ |
T12900 | 23895-23904 | NN | denotes | apoptosis |
T12899 | 23883-23894 | JJ | denotes | TNF-induced |
T12898 | 23874-23882 | VB | denotes | inhibits |
T12897 | 23865-23873 | RB | denotes | strongly |
T12896 | 23860-23864 | RB | denotes | also |
T12895 | 23853-23859 | NN | denotes | ABIN-1 |
T12894 | 23851-23852 | -COMMA- | denotes | , |
T12893 | 23848-23851 | NN | denotes | A20 |
T12892 | 23844-23847 | IN | denotes | for |
T12891 | 23841-23843 | IN | denotes | As |
T12890 | 23838-23839 | -RRB- | denotes | ] |
T12889 | 23836-23838 | CD | denotes | 57 |
T12888 | 23835-23836 | -LRB- | denotes | [ |
T12887 | 23828-23834 | NN | denotes | domain |
T12886 | 23810-23827 | JJ | denotes | ubiquitin-binding |
T12885 | 23802-23809 | JJ | denotes | crucial |
T12884 | 23798-23801 | DT | denotes | the |
T12883 | 23790-23797 | VB | denotes | lacking |
T12882 | 23785-23789 | NN | denotes | form |
T12881 | 23776-23784 | JJ | denotes | inactive |
T12880 | 23772-23775 | CC | denotes | and |
T12879 | 23762-23771 | VB | denotes | truncated |
T12878 | 23760-23761 | DT | denotes | a |
T12877 | 23752-23759 | VB | denotes | express |
T12876 | 23747-23751 | RB | denotes | only |
T12875 | 23742-23746 | NN | denotes | mice |
T12874 | 23738-23741 | CC | denotes | but |
T12873 | 23736-23737 | -COMMA- | denotes | , |
T12872 | 23730-23736 | NN | denotes | humans |
T12871 | 23727-23729 | IN | denotes | in |
T12870 | 23717-23726 | VB | denotes | expressed |
T12869 | 23714-23716 | VB | denotes | is |
T12868 | 23707-23713 | NN | denotes | ABIN-3 |
T12867 | 23696-23706 | JJ | denotes | Functional |
T12866 | 23693-23694 | -RRB- | denotes | ] |
T12865 | 23688-23693 | CD | denotes | 55,56 |
T12864 | 23687-23688 | -LRB- | denotes | [ |
T12863 | 23681-23686 | NN | denotes | ABINs |
T12862 | 23672-23680 | JJ | denotes | multiple |
T12861 | 23669-23671 | IN | denotes | of |
T12860 | 23658-23668 | NN | denotes | activities |
T12859 | 23647-23657 | JJ | denotes | inhibitory |
T12858 | 23641-23646 | NN | denotes | NF-κB |
T12857 | 23631-23640 | JJ | denotes | redundant |
T12856 | 23620-23630 | VB | denotes | reflecting |
T12855 | 23611-23619 | RB | denotes | possibly |
T12854 | 23609-23610 | -COMMA- | denotes | , |
T12853 | 23597-23609 | RB | denotes | respectively |
T12852 | 23595-23596 | -COMMA- | denotes | , |
T12851 | 23586-23595 | NN | denotes | responses |
T12850 | 23580-23585 | NN | denotes | NF-κB |
T12849 | 23573-23579 | JJ | denotes | normal |
T12848 | 23570-23572 | CC | denotes | or |
T12847 | 23560-23569 | VB | denotes | increased |
T12846 | 23551-23559 | RB | denotes | slightly |
T12845 | 23546-23550 | RB | denotes | only |
T12844 | 23538-23545 | VB | denotes | exhibit |
T12843 | 23533-23537 | NN | denotes | mice |
T12842 | 23516-23532 | JJ | denotes | ABIN-2-deficient |
T12841 | 23512-23515 | CC | denotes | and |
T12840 | 23495-23511 | JJ | denotes | ABIN-1-deficient |
T12839 | 23490-23494 | CC | denotes | both |
T12838 | 23488-23489 | -COMMA- | denotes | , |
T12837 | 23476-23488 | RB | denotes | Unexpectedly |
T12836 | 23473-23474 | -RRB- | denotes | ) |
T12835 | 23472-23473 | -RRB- | denotes | ] |
T12834 | 23470-23472 | CD | denotes | 54 |
T12833 | 23469-23470 | -LRB- | denotes | [ |
T12832 | 23466-23468 | IN | denotes | in |
T12831 | 23457-23465 | VB | denotes | reviewed |
T12830 | 23456-23457 | -LRB- | denotes | ( |
T12829 | 23445-23455 | NN | denotes | activation |
T12828 | 23439-23444 | NN | denotes | NF-κB |
T12827 | 23436-23438 | IN | denotes | of |
T12826 | 23425-23435 | NN | denotes | regulation |
T12825 | 23416-23424 | NN | denotes | feedback |
T12824 | 23407-23415 | JJ | denotes | negative |
T12823 | 23403-23406 | DT | denotes | the |
T12822 | 23400-23402 | IN | denotes | in |
T12821 | 23392-23399 | NN | denotes | complex |
T12820 | 23383-23391 | NN | denotes | A20/ABIN |
T12819 | 23379-23382 | DT | denotes | the |
T12818 | 23375-23378 | IN | denotes | for |
T12817 | 23370-23374 | NN | denotes | role |
T12816 | 23360-23369 | JJ | denotes | potential |
T12815 | 23358-23359 | DT | denotes | a |
T12814 | 23346-23357 | VB | denotes | implicating |
T12813 | 23344-23345 | -COMMA- | denotes | , |
T12812 | 23335-23344 | JJ | denotes | dependent |
T12811 | 23329-23334 | NN | denotes | NF-κB |
T12810 | 23326-23328 | VB | denotes | is |
T12809 | 23315-23325 | NN | denotes | expression |
T12808 | 23308-23314 | NN | denotes | ABIN-3 |
T12807 | 23304-23307 | CC | denotes | and |
T12806 | 23297-23303 | NN | denotes | ABIN-1 |
T12805 | 23295-23296 | -COMMA- | denotes | , |
T12804 | 23292-23295 | NN | denotes | A20 |
T12803 | 23289-23291 | TO | denotes | to |
T12802 | 23281-23288 | JJ | denotes | Similar |
T12801 | 23278-23279 | -RRB- | denotes | ] |
T12800 | 23273-23278 | CD | denotes | 43,44 |
T12799 | 23272-23273 | -LRB- | denotes | [ |
T12798 | 23261-23271 | NN | denotes | substrates |
T12797 | 23243-23260 | VB | denotes | polyubiquitinated |
T12796 | 23240-23242 | TO | denotes | to |
T12795 | 23236-23239 | NN | denotes | A20 |
T12794 | 23229-23235 | VB | denotes | target |
T12793 | 23226-23228 | TO | denotes | to |
T12792 | 23217-23225 | VB | denotes | proposed |
T12791 | 23212-23216 | VB | denotes | been |
T12790 | 23207-23211 | VB | denotes | have |
T12789 | 23202-23206 | PRP | denotes | they |
T12788 | 23200-23201 | -COMMA- | denotes | , |
T12787 | 23195-23200 | NN | denotes | motif |
T12786 | 23177-23194 | JJ | denotes | ubiquitin-binding |
T12785 | 23168-23176 | JJ | denotes | specific |
T12784 | 23166-23167 | DT | denotes | a |
T12783 | 23158-23165 | VB | denotes | contain |
T12782 | 23152-23157 | NN | denotes | ABINs |
T12781 | 23144-23151 | IN | denotes | Because |
T12780 | 23128-23142 | NN | denotes | overexpression |
T12779 | 23123-23127 | IN | denotes | upon |
T12778 | 23115-23122 | NN | denotes | stimuli |
T12777 | 23102-23114 | JJ | denotes | inflammatory |
T12776 | 23096-23101 | JJ | denotes | other |
T12775 | 23088-23095 | JJ | denotes | several |
T12774 | 23084-23087 | CC | denotes | and |
T12773 | 23080-23083 | NN | denotes | TNF |
T12772 | 23077-23079 | IN | denotes | by |
T12771 | 23066-23076 | NN | denotes | activation |
T12770 | 23060-23065 | NN | denotes | NF-κB |
T12769 | 23052-23059 | VB | denotes | inhibit |
T12768 | 23049-23051 | TO | denotes | to |
T12767 | 23043-23048 | VB | denotes | shown |
T12766 | 23038-23042 | VB | denotes | were |
T12765 | 23034-23037 | CC | denotes | and |
T12764 | 23025-23033 | NN | denotes | proteins |
T12763 | 23013-23024 | VB | denotes | interacting |
T12762 | 23009-23012 | NN | denotes | A20 |
T12761 | 22999-23008 | VB | denotes | expressed |
T12760 | 22986-22998 | RB | denotes | ubiquitously |
T12759 | 22983-22985 | IN | denotes | as |
T12758 | 22972-22982 | VB | denotes | identified |
T12757 | 22967-22971 | VB | denotes | were |
T12756 | 22965-22966 | -RRB- | denotes | ) |
T12755 | 22959-22965 | NN | denotes | TNIP-3 |
T12754 | 22955-22958 | CC | denotes | and |
T10168 | 20124-20130 | PRP | denotes | itself |
T10253 | 20665-20672 | NN | denotes | protein |
T10252 | 20648-20664 | JJ | denotes | chemo-attractant |
T10251 | 20639-20647 | NN | denotes | monocyte |
T10250 | 20637-20638 | -COMMA- | denotes | , |
T10249 | 20632-20637 | NN | denotes | RANKL |
T10248 | 20624-20631 | JJ | denotes | soluble |
T10247 | 20622-20623 | -COMMA- | denotes | , |
T10246 | 20618-20622 | NN | denotes | IL-6 |
T10245 | 20616-20617 | -COMMA- | denotes | , |
T10244 | 20611-20616 | NN | denotes | IL-1β |
T10243 | 20609-20610 | -COMMA- | denotes | , |
T10242 | 20606-20609 | NN | denotes | TNF |
T10241 | 20603-20605 | IN | denotes | of |
T10240 | 20596-20602 | NN | denotes | levels |
T10239 | 20586-20595 | VB | denotes | decreased |
T10238 | 20582-20585 | CC | denotes | and |
T10237 | 20573-20581 | NN | denotes | activity |
T10236 | 20567-20572 | NN | denotes | NF-κB |
T10235 | 20564-20566 | IN | denotes | of |
T10234 | 20553-20563 | NN | denotes | inhibition |
T10233 | 20548-20552 | IN | denotes | with |
T10232 | 20537-20547 | VB | denotes | associated |
T10231 | 20533-20536 | VB | denotes | was |
T10230 | 20526-20532 | NN | denotes | tissue |
T10229 | 20517-20525 | JJ | denotes | synovial |
T10228 | 20514-20516 | IN | denotes | in |
T10227 | 20503-20513 | NN | denotes | expression |
T10226 | 20499-20502 | NN | denotes | A20 |
T10225 | 20490-20497 | NN | denotes | setting |
T10224 | 20478-20489 | JJ | denotes | therapeutic |
T10223 | 20474-20477 | CC | denotes | and |
T10222 | 20461-20473 | JJ | denotes | prophylactic |
T10221 | 20459-20460 | DT | denotes | a |
T10220 | 20454-20458 | CC | denotes | both |
T10219 | 20451-20453 | IN | denotes | in |
T10218 | 20449-20450 | -COMMA- | denotes | , |
T10217 | 20443-20449 | NN | denotes | joints |
T10216 | 20433-20442 | JJ | denotes | untreated |
T10215 | 20430-20432 | IN | denotes | in |
T10214 | 20425-20429 | RB | denotes | even |
T10213 | 20423-20424 | -COMMA- | denotes | , |
T10212 | 20414-20423 | NN | denotes | arthritis |
T10211 | 20397-20413 | JJ | denotes | collagen-induced |
T10210 | 20394-20396 | IN | denotes | of |
T10209 | 20388-20393 | NN | denotes | model |
T10208 | 20382-20387 | NN | denotes | mouse |
T10207 | 20380-20381 | DT | denotes | a |
T10206 | 20377-20379 | IN | denotes | in |
T10205 | 20365-20376 | NN | denotes | destruction |
T10204 | 20359-20364 | JJ | denotes | joint |
T10203 | 20355-20358 | CC | denotes | and |
T10202 | 20342-20354 | NN | denotes | inflammation |
T10201 | 20333-20341 | JJ | denotes | synovial |
T10200 | 20330-20332 | IN | denotes | of |
T10199 | 20321-20329 | NN | denotes | severity |
T10198 | 20317-20320 | DT | denotes | the |
T10197 | 20310-20316 | VB | denotes | reduce |
T10196 | 20307-20309 | TO | denotes | to |
T10195 | 20301-20306 | VB | denotes | shown |
T10194 | 20297-20300 | VB | denotes | was |
T10193 | 20286-20296 | NN | denotes | adenovirus |
T10192 | 20271-20285 | JJ | denotes | A20-expressing |
T10191 | 20268-20270 | DT | denotes | an |
T10190 | 20265-20267 | IN | denotes | of |
T10189 | 20255-20264 | NN | denotes | injection |
T10188 | 20239-20254 | JJ | denotes | intra-articular |
T10187 | 20237-20238 | -COMMA- | denotes | , |
T10186 | 20229-20237 | RB | denotes | Recently |
T10185 | 20217-20227 | NN | denotes | signalling |
T10184 | 20211-20216 | NN | denotes | NF-κB |
T10183 | 20208-20210 | IN | denotes | of |
T10182 | 20197-20207 | NN | denotes | regulation |
T10181 | 20188-20196 | NN | denotes | feedback |
T10180 | 20179-20187 | JJ | denotes | negative |
T10179 | 20175-20178 | DT | denotes | the |
T10178 | 20172-20174 | IN | denotes | in |
T10177 | 20168-20171 | NN | denotes | A20 |
T10176 | 20156-20167 | VB | denotes | implicating |
T10175 | 20154-20155 | -COMMA- | denotes | , |
T10174 | 20153-20154 | -RRB- | denotes | ] |
T10173 | 20151-20153 | CD | denotes | 50 |
T10172 | 20150-20151 | -LRB- | denotes | [ |
T10171 | 20144-20149 | NN | denotes | NF-κB |
T10170 | 20141-20143 | IN | denotes | by |
T10169 | 20131-20140 | VB | denotes | regulated |
T10167 | 20121-20123 | VB | denotes | is |
T10166 | 20110-20120 | NN | denotes | expression |
T10165 | 20106-20109 | NN | denotes | A20 |
T10164 | 20104-20105 | -COMMA- | denotes | , |
T10163 | 20091-20104 | RB | denotes | Interestingly |
T10162 | 20078-20089 | NN | denotes | lymphocytes |
T10161 | 20074-20077 | CC | denotes | and |
T10160 | 20061-20073 | NN | denotes | synoviocytes |
T10159 | 20059-20060 | -COMMA- | denotes | , |
T10158 | 20048-20059 | NN | denotes | fibroblasts |
T10157 | 20045-20047 | IN | denotes | as |
T10156 | 20040-20044 | JJ | denotes | such |
T10155 | 20038-20039 | -COMMA- | denotes | , |
T10154 | 20036-20038 | NN | denotes | RA |
T10153 | 20033-20035 | IN | denotes | of |
T10152 | 20017-20032 | NN | denotes | pathophysiology |
T10151 | 20013-20016 | DT | denotes | the |
T10150 | 20010-20012 | IN | denotes | in |
T10149 | 20004-20009 | NN | denotes | roles |
T10148 | 19994-20003 | JJ | denotes | important |
T10147 | 19989-19993 | VB | denotes | play |
T10146 | 19984-19988 | WDT | denotes | that |
T10145 | 19978-19983 | NN | denotes | types |
T10144 | 19973-19977 | NN | denotes | cell |
T10143 | 19965-19972 | JJ | denotes | several |
T10142 | 19962-19964 | IN | denotes | in |
T10141 | 19953-19961 | VB | denotes | observed |
T10140 | 19948-19952 | VB | denotes | been |
T10139 | 19944-19947 | VB | denotes | has |
T10138 | 19933-19943 | NN | denotes | expression |
T10137 | 19929-19932 | NN | denotes | A20 |
T10136 | 19926-19927 | -RRB- | denotes | ] |
T10135 | 19921-19926 | CD | denotes | 48,49 |
T10134 | 19920-19921 | -LRB- | denotes | [ |
T10133 | 19911-19919 | NN | denotes | survival |
T10132 | 19904-19910 | NN | denotes | B-cell |
T10131 | 19891-19903 | JJ | denotes | unrestricted |
T10130 | 19888-19890 | TO | denotes | to |
T10129 | 19880-19887 | VB | denotes | leading |
T10128 | 19874-19879 | NN | denotes | cells |
T10127 | 19872-19873 | NN | denotes | B |
T10126 | 19869-19871 | IN | denotes | in |
T10125 | 19859-19868 | NN | denotes | responses |
T10124 | 19853-19858 | NN | denotes | NF-κB |
T10123 | 19841-19852 | JJ | denotes | hyperactive |
T10122 | 19838-19840 | TO | denotes | to |
T10121 | 19834-19837 | JJ | denotes | due |
T10120 | 19821-19833 | NN | denotes | autoimmunity |
T10119 | 19813-19820 | VB | denotes | develop |
T10118 | 19807-19812 | NN | denotes | cells |
T10117 | 19805-19806 | NN | denotes | B |
T10116 | 19802-19804 | IN | denotes | in |
T10115 | 19798-19801 | NN | denotes | A20 |
T10114 | 19790-19797 | VB | denotes | lacking |
T10113 | 19785-19789 | NN | denotes | mice |
T10112 | 19780-19784 | IN | denotes | that |
T10111 | 19773-19779 | VB | denotes | showed |
T10110 | 19765-19772 | NN | denotes | studies |
T10109 | 19753-19764 | JJ | denotes | independent |
T10108 | 19749-19752 | CD | denotes | Two |
T10107 | 19746-19747 | -RRB- | denotes | ] |
T10106 | 19744-19746 | CD | denotes | 47 |
T10105 | 19743-19744 | -LRB- | denotes | [ |
T10104 | 19732-19742 | NN | denotes | epithelium |
T10103 | 19721-19731 | JJ | denotes | intestinal |
T10102 | 19717-19720 | DT | denotes | the |
T10101 | 19714-19716 | IN | denotes | in |
T10100 | 19706-19713 | NN | denotes | protein |
T10099 | 19692-19705 | JJ | denotes | antiapoptotic |
T10098 | 19686-19691 | JJ | denotes | major |
T10097 | 19684-19685 | DT | denotes | a |
T10096 | 19681-19683 | IN | denotes | as |
T10095 | 19677-19680 | NN | denotes | A20 |
T10094 | 19666-19676 | VB | denotes | confirming |
T10093 | 19664-19665 | -COMMA- | denotes | , |
T10092 | 19655-19664 | NN | denotes | apoptosis |
T10091 | 19643-19654 | JJ | denotes | TNF-induced |
T10090 | 19640-19642 | TO | denotes | to |
T10089 | 19634-19639 | NN | denotes | cells |
T10088 | 19623-19633 | JJ | denotes | epithelial |
T10087 | 19612-19622 | JJ | denotes | intestinal |
T10086 | 19606-19611 | PRP-DOLLAR- | denotes | their |
T10085 | 19603-19605 | IN | denotes | of |
T10084 | 19586-19602 | NN | denotes | hypersensitivity |
T10083 | 19582-19585 | DT | denotes | the |
T10082 | 19579-19581 | TO | denotes | to |
T10081 | 19575-19578 | JJ | denotes | due |
T10080 | 19567-19574 | NN | denotes | colitis |
T10079 | 19554-19566 | JJ | denotes | experimental |
T10078 | 19551-19553 | TO | denotes | to |
T10077 | 19536-19550 | NN | denotes | susceptibility |
T10076 | 19526-19535 | VB | denotes | increased |
T10075 | 19518-19525 | VB | denotes | exhibit |
T10074 | 19512-19517 | NN | denotes | cells |
T10073 | 19501-19511 | JJ | denotes | epithelial |
T10072 | 19490-19500 | JJ | denotes | intestinal |
T10071 | 19487-19489 | IN | denotes | in |
T10070 | 19483-19486 | NN | denotes | A20 |
T10069 | 19475-19482 | VB | denotes | lacking |
T10068 | 19462-19474 | RB | denotes | specifically |
T10067 | 19457-19461 | NN | denotes | mice |
T10066 | 19452-19456 | IN | denotes | that |
T10065 | 19445-19451 | VB | denotes | showed |
T10064 | 19436-19444 | RB | denotes | recently |
T10063 | 19433-19435 | PRP | denotes | We |
T10062 | 19424-19431 | NN | denotes | protein |
T10061 | 19410-19423 | JJ | denotes | antiapoptotic |
T10060 | 19407-19409 | DT | denotes | an |
T10059 | 19404-19406 | IN | denotes | as |
T10058 | 19399-19403 | NN | denotes | role |
T10057 | 19395-19398 | PRP-DOLLAR- | denotes | its |
T10056 | 19384-19394 | VB | denotes | confirming |
T10055 | 19382-19383 | -COMMA- | denotes | , |
T10054 | 19373-19382 | NN | denotes | apoptosis |
T10053 | 19360-19372 | JJ | denotes | TNF-mediated |
T10052 | 19357-19359 | TO | denotes | to |
T10051 | 19345-19356 | JJ | denotes | susceptible |
T10050 | 19340-19344 | RB | denotes | more |
T10049 | 19335-19339 | RB | denotes | also |
T10048 | 19331-19334 | VB | denotes | are |
T10047 | 19325-19330 | NN | denotes | cells |
T10046 | 19311-19324 | JJ | denotes | A20-deficient |
T10045 | 19308-19309 | -RRB- | denotes | ] |
T10044 | 19306-19308 | CD | denotes | 46 |
T10043 | 19305-19306 | -LRB- | denotes | [ |
T10042 | 19296-19304 | NN | denotes | molecule |
T10041 | 19291-19295 | DT | denotes | this |
T10040 | 19288-19290 | IN | denotes | of |
T10039 | 19279-19287 | NN | denotes | function |
T10038 | 19261-19278 | JJ | denotes | anti-inflammatory |
T10443 | 21845-21849 | NN | denotes | 6q23 |
T10442 | 21841-21844 | DT | denotes | the |
T10441 | 21838-21840 | IN | denotes | in |
T10440 | 21832-21837 | NN | denotes | locus |
T10439 | 21828-21831 | NN | denotes | A20 |
T10438 | 21824-21827 | DT | denotes | the |
T10437 | 21821-21823 | IN | denotes | in |
T10436 | 21811-21820 | NN | denotes | mutations |
T10435 | 21803-21810 | IN | denotes | between |
T10434 | 21791-21802 | NN | denotes | association |
T10433 | 21785-21790 | JJ | denotes | clear |
T10432 | 21783-21784 | DT | denotes | a |
T10431 | 21774-21782 | VB | denotes | revealed |
T10430 | 21769-21773 | RB | denotes | also |
T10429 | 21761-21768 | NN | denotes | studies |
T10428 | 21749-21760 | NN | denotes | association |
T10427 | 21737-21748 | JJ | denotes | genome-wide |
T10426 | 21729-21736 | JJ | denotes | Several |
T10425 | 21726-21727 | -RRB- | denotes | ) |
T10424 | 21725-21726 | -RRB- | denotes | ] |
T10423 | 21723-21725 | CD | denotes | 52 |
T10422 | 21722-21723 | -LRB- | denotes | [ |
T10421 | 21719-21721 | IN | denotes | in |
T10420 | 21710-21718 | VB | denotes | reviewed |
T10419 | 21709-21710 | -LRB- | denotes | ( |
T10418 | 21697-21708 | NN | denotes | pathologies |
T10417 | 21686-21696 | JJ | denotes | autoimmune |
T10416 | 21683-21685 | IN | denotes | of |
T10415 | 21671-21682 | NN | denotes | development |
T10414 | 21668-21670 | TO | denotes | to |
T10413 | 21653-21667 | NN | denotes | susceptibility |
T10412 | 21643-21652 | VB | denotes | increased |
T10411 | 21638-21642 | IN | denotes | with |
T10410 | 21627-21637 | VB | denotes | associated |
T10409 | 21622-21626 | VB | denotes | been |
T10408 | 21617-21621 | VB | denotes | have |
T10407 | 21611-21616 | NN | denotes | locus |
T10406 | 21607-21610 | NN | denotes | A20 |
T10405 | 21601-21606 | JJ | denotes | human |
T10404 | 21597-21600 | DT | denotes | the |
T10403 | 21594-21596 | IN | denotes | in |
T10402 | 21589-21593 | NN | denotes | SNPs |
T10401 | 21581-21588 | JJ | denotes | several |
T10400 | 21579-21580 | -COMMA- | denotes | , |
T10399 | 21568-21579 | RB | denotes | Importantly |
T10398 | 21561-21566 | NN | denotes | cells |
T10397 | 21559-21560 | NN | denotes | T |
T10396 | 21556-21558 | CC | denotes | or |
T10395 | 21550-21555 | NN | denotes | cells |
T10394 | 21548-21549 | NN | denotes | B |
T10393 | 21546-21547 | -COMMA- | denotes | , |
T10392 | 21541-21546 | NN | denotes | cells |
T10391 | 21531-21540 | JJ | denotes | dendritic |
T10390 | 21529-21530 | -COMMA- | denotes | , |
T10389 | 21518-21529 | NN | denotes | macrophages |
T10388 | 21516-21517 | -COMMA- | denotes | , |
T10387 | 21505-21516 | NN | denotes | fibroblasts |
T10386 | 21496-21504 | JJ | denotes | synovial |
T10385 | 21493-21495 | IN | denotes | as |
T10384 | 21488-21492 | JJ | denotes | such |
T10383 | 21482-21487 | NN | denotes | types |
T10382 | 21477-21481 | NN | denotes | cell |
T10381 | 21468-21476 | JJ | denotes | specific |
T10380 | 21465-21467 | IN | denotes | in |
T10379 | 21461-21464 | NN | denotes | A20 |
T10378 | 21456-21460 | VB | denotes | lack |
T10377 | 21451-21455 | WDT | denotes | that |
T10376 | 21446-21450 | NN | denotes | mice |
T10375 | 21437-21445 | NN | denotes | knockout |
T10374 | 21425-21436 | JJ | denotes | conditional |
T10373 | 21422-21424 | IN | denotes | of |
T10372 | 21407-21421 | NN | denotes | susceptibility |
T10371 | 21403-21406 | DT | denotes | the |
T10370 | 21396-21402 | JJ | denotes | future |
T10369 | 21393-21395 | IN | denotes | in |
T10368 | 21385-21392 | VB | denotes | analyse |
T10367 | 21382-21384 | TO | denotes | to |
T10366 | 21370-21381 | JJ | denotes | interesting |
T10365 | 21367-21369 | VB | denotes | be |
T10364 | 21362-21366 | MD | denotes | will |
T10363 | 21359-21361 | PRP | denotes | It |
T10362 | 21349-21357 | NN | denotes | activity |
T10361 | 21345-21348 | CC | denotes | and |
T10360 | 21338-21344 | NN | denotes | number |
T10359 | 21327-21337 | NN | denotes | osteoclast |
T10358 | 21323-21326 | DT | denotes | the |
T10357 | 21312-21322 | VB | denotes | decreasing |
T10356 | 21304-21311 | IN | denotes | through |
T10355 | 21292-21303 | NN | denotes | destruction |
T10354 | 21286-21291 | JJ | denotes | joint |
T10353 | 21277-21285 | VB | denotes | minimise |
T10352 | 21267-21276 | RB | denotes | therefore |
T10351 | 21261-21266 | MD | denotes | might |
T10350 | 21257-21260 | NN | denotes | A20 |
T10349 | 21249-21255 | NN | denotes | tissue |
T10348 | 21243-21248 | JJ | denotes | joint |
T10347 | 21240-21242 | IN | denotes | in |
T10346 | 21228-21239 | NN | denotes | osteoclasts |
T10345 | 21218-21227 | VB | denotes | activated |
T10344 | 21215-21217 | IN | denotes | of |
T10343 | 21208-21214 | NN | denotes | number |
T10342 | 21204-21207 | DT | denotes | the |
T10341 | 21201-21203 | IN | denotes | in |
T10340 | 21192-21200 | NN | denotes | decrease |
T10339 | 21190-21191 | DT | denotes | a |
T10338 | 21187-21189 | TO | denotes | to |
T10337 | 21181-21186 | VB | denotes | leads |
T10336 | 21166-21180 | NN | denotes | overexpression |
T10335 | 21162-21165 | NN | denotes | A20 |
T10334 | 21157-21161 | IN | denotes | that |
T10333 | 21144-21156 | VB | denotes | demonstrated |
T10332 | 21139-21143 | RB | denotes | also |
T10331 | 21133-21138 | NN | denotes | study |
T10330 | 21128-21132 | DT | denotes | This |
T10329 | 21118-21126 | NN | denotes | findings |
T10328 | 21105-21117 | JJ | denotes | radiological |
T10327 | 21101-21104 | CC | denotes | and |
T10326 | 21099-21100 | -COMMA- | denotes | , |
T10325 | 21087-21099 | JJ | denotes | pathological |
T10324 | 21085-21086 | -COMMA- | denotes | , |
T10323 | 21077-21085 | JJ | denotes | clinical |
T10322 | 21073-21076 | DT | denotes | the |
T10321 | 21070-21072 | IN | denotes | in |
T10320 | 21062-21069 | NN | denotes | effects |
T10319 | 21051-21061 | JJ | denotes | beneficial |
T10318 | 21047-21050 | DT | denotes | the |
T10317 | 21039-21046 | VB | denotes | explain |
T10316 | 21033-21038 | MD | denotes | might |
T10315 | 21028-21032 | NN | denotes | mice |
T10314 | 21013-21027 | JJ | denotes | A20-transduced |
T10313 | 21010-21012 | IN | denotes | in |
T10312 | 21004-21009 | NN | denotes | IL-1β |
T10311 | 21000-21003 | CC | denotes | and |
T10310 | 20996-20999 | NN | denotes | TNF |
T10309 | 20993-20995 | IN | denotes | of |
T10308 | 20986-20992 | NN | denotes | levels |
T10307 | 20980-20985 | NN | denotes | serum |
T10306 | 20970-20979 | VB | denotes | decreased |
T10305 | 20966-20969 | DT | denotes | the |
T10304 | 20964-20965 | -COMMA- | denotes | , |
T10303 | 20962-20964 | NN | denotes | RA |
T10302 | 20959-20961 | IN | denotes | in |
T10301 | 20954-20958 | NN | denotes | bone |
T10300 | 20950-20953 | CC | denotes | and |
T10299 | 20940-20949 | NN | denotes | cartilage |
T10298 | 20937-20939 | IN | denotes | of |
T10297 | 20929-20936 | NN | denotes | erosion |
T10296 | 20925-20928 | CC | denotes | and |
T10295 | 20923-20924 | -COMMA- | denotes | , |
T10294 | 20914-20923 | NN | denotes | formation |
T10293 | 20907-20913 | NN | denotes | pannus |
T10292 | 20905-20906 | -COMMA- | denotes | , |
T10291 | 20896-20905 | NN | denotes | synovitis |
T10290 | 20888-20895 | VB | denotes | mediate |
T10289 | 20885-20887 | TO | denotes | to |
T10288 | 20879-20884 | VB | denotes | known |
T10287 | 20875-20878 | VB | denotes | are |
T10286 | 20869-20874 | NN | denotes | IL-1β |
T10285 | 20865-20868 | CC | denotes | and |
T10284 | 20861-20864 | NN | denotes | TNF |
T10283 | 20853-20860 | IN | denotes | Because |
T10282 | 20850-20851 | -RRB- | denotes | ] |
T10281 | 20848-20850 | CD | denotes | 51 |
T10280 | 20847-20848 | -LRB- | denotes | [ |
T10279 | 20836-20846 | NN | denotes | expression |
T10278 | 20831-20835 | NN | denotes | gene |
T10277 | 20818-20830 | JJ | denotes | κB-dependent |
T10276 | 20814-20817 | NF- | denotes | NF- |
T10275 | 20810-20813 | CC | denotes | and |
T10274 | 20799-20809 | NN | denotes | activation |
T10273 | 20793-20798 | NN | denotes | NF-κB |
T10272 | 20790-20792 | IN | denotes | of |
T10271 | 20778-20789 | NN | denotes | suppression |
T10270 | 20770-20777 | IN | denotes | through |
T10269 | 20765-20769 | NN | denotes | mice |
T10268 | 20755-20764 | NN | denotes | arthritis |
T10267 | 20738-20754 | JJ | denotes | collagen-induced |
T10266 | 20735-20737 | IN | denotes | in |
T10265 | 20728-20734 | NN | denotes | effect |
T10264 | 20717-20727 | JJ | denotes | protective |
T10263 | 20715-20716 | DT | denotes | a |
T10262 | 20707-20714 | VB | denotes | induces |
T10261 | 20703-20706 | NN | denotes | A20 |
T10260 | 20698-20702 | IN | denotes | that |
T10259 | 20687-20697 | VB | denotes | suggesting |
T10258 | 20685-20686 | -COMMA- | denotes | , |
T10257 | 20680-20685 | NN | denotes | IL-17 |
T10256 | 20676-20679 | CC | denotes | and |
T10255 | 20674-20675 | -COMMA- | denotes | , |
T10254 | 20673-20674 | CD | denotes | 1 |
T9976 | 18895-18902 | NN | denotes | protein |
T9975 | 18882-18894 | JJ | denotes | Tax1-binding |
T9974 | 18878-18881 | CC | denotes | and |
T9973 | 18876-18877 | CD | denotes | 1 |
T9972 | 18874-18875 | -RRB- | denotes | ) |
T9971 | 18870-18874 | NN | denotes | ABIN |
T9970 | 18869-18870 | -LRB- | denotes | ( |
T9969 | 18863-18868 | NN | denotes | NF-κB |
T9968 | 18860-18862 | IN | denotes | of |
T9967 | 18850-18859 | NN | denotes | inhibitor |
T9966 | 18838-18849 | JJ | denotes | A20-binding |
T9965 | 18828-18837 | VB | denotes | including |
T9964 | 18826-18827 | -COMMA- | denotes | , |
T9963 | 18818-18826 | NN | denotes | proteins |
T9962 | 18810-18817 | NN | denotes | adaptor |
T9961 | 18792-18809 | JJ | denotes | ubiquitin-binding |
T9960 | 18783-18791 | JJ | denotes | specific |
T9959 | 18774-18782 | VB | denotes | requires |
T9958 | 18766-18773 | NN | denotes | targets |
T9957 | 18762-18765 | PRP-DOLLAR- | denotes | its |
T9956 | 18757-18761 | IN | denotes | with |
T9955 | 18753-18756 | NN | denotes | A20 |
T9954 | 18750-18752 | IN | denotes | of |
T9953 | 18738-18749 | NN | denotes | association |
T9952 | 18734-18737 | DT | denotes | The |
T9951 | 18731-18732 | -RRB- | denotes | ] |
T9950 | 18729-18731 | CD | denotes | 42 |
T9949 | 18728-18729 | -LRB- | denotes | [ |
T9948 | 18717-18727 | NN | denotes | signalling |
T9947 | 18711-18716 | NN | denotes | NF-κB |
T9946 | 18698-18710 | VB | denotes | downregulate |
T9945 | 18695-18697 | TO | denotes | to |
T9944 | 18691-18694 | NN | denotes | A20 |
T9943 | 18688-18690 | IN | denotes | by |
T9942 | 18683-18687 | VB | denotes | used |
T9941 | 18673-18682 | NN | denotes | mechanism |
T9940 | 18663-18672 | JJ | denotes | important |
T9939 | 18655-18662 | DT | denotes | another |
T9938 | 18652-18654 | IN | denotes | as |
T9937 | 18642-18651 | VB | denotes | described |
T9936 | 18637-18641 | VB | denotes | were |
T9935 | 18635-18636 | -RRB- | denotes | ) |
T9934 | 18628-18635 | NN | denotes | cIAP1/2 |
T9933 | 18624-18627 | CC | denotes | and |
T9932 | 18618-18623 | NN | denotes | TRAF2 |
T9931 | 18616-18617 | -COMMA- | denotes | , |
T9930 | 18611-18616 | NN | denotes | TRAF6 |
T9929 | 18610-18611 | -LRB- | denotes | ( |
T9928 | 18602-18609 | NN | denotes | ligases |
T9927 | 18592-18601 | NN | denotes | ubiquitin |
T9926 | 18589-18591 | NN | denotes | E3 |
T9925 | 18585-18588 | CC | denotes | and |
T9924 | 18583-18584 | -RRB- | denotes | ) |
T9923 | 18577-18583 | NN | denotes | Ubc5hc |
T9922 | 18573-18576 | CC | denotes | and |
T9921 | 18567-18572 | NN | denotes | Ubc13 |
T9920 | 18566-18567 | -LRB- | denotes | ( |
T9919 | 18558-18565 | NN | denotes | enzymes |
T9918 | 18546-18557 | VB | denotes | conjugating |
T9917 | 18536-18545 | NN | denotes | ubiquitin |
T9916 | 18533-18535 | NN | denotes | E2 |
T9915 | 18525-18532 | IN | denotes | between |
T9914 | 18512-18524 | NN | denotes | interactions |
T9913 | 18509-18511 | IN | denotes | of |
T9912 | 18498-18508 | NN | denotes | disruption |
T9911 | 18494-18497 | DT | denotes | the |
T9910 | 18492-18493 | -COMMA- | denotes | , |
T9909 | 18484-18492 | RB | denotes | Recently |
T9908 | 18481-18482 | -RRB- | denotes | ) |
T9907 | 18480-18481 | CD | denotes | 1 |
T9906 | 18473-18479 | NN | denotes | Figure |
T9905 | 18472-18473 | -LRB- | denotes | ( |
T9904 | 18470-18471 | -RRB- | denotes | ] |
T9903 | 18465-18470 | CD | denotes | 38-41 |
T9902 | 18464-18465 | -LRB- | denotes | [ |
T9901 | 18451-18463 | NN | denotes | interactions |
T9900 | 18435-18450 | JJ | denotes | protein-protein |
T9899 | 18426-18434 | JJ | denotes | specific |
T9898 | 18417-18425 | VB | denotes | disrupts |
T9897 | 18411-18416 | WDT | denotes | which |
T9896 | 18409-18410 | -COMMA- | denotes | , |
T9895 | 18404-18409 | NN | denotes | MALT1 |
T9894 | 18400-18403 | CC | denotes | and |
T9893 | 18394-18399 | NN | denotes | TRAF6 |
T9892 | 18392-18393 | -COMMA- | denotes | , |
T9891 | 18388-18392 | NN | denotes | RIP2 |
T9890 | 18386-18387 | -COMMA- | denotes | , |
T9889 | 18382-18386 | NN | denotes | RIP1 |
T9888 | 18379-18381 | IN | denotes | as |
T9887 | 18374-18378 | JJ | denotes | such |
T9886 | 18372-18373 | -COMMA- | denotes | , |
T9885 | 18363-18372 | NN | denotes | molecules |
T9884 | 18352-18362 | NN | denotes | signalling |
T9883 | 18346-18351 | NN | denotes | NF-κB |
T9882 | 18337-18345 | JJ | denotes | specific |
T9881 | 18320-18336 | VB | denotes | deubiquitinating |
T9880 | 18317-18319 | IN | denotes | by |
T9879 | 18308-18316 | NN | denotes | function |
T9878 | 18302-18307 | NN | denotes | NF-κB |
T9877 | 18294-18301 | VB | denotes | inhibit |
T9876 | 18291-18293 | TO | denotes | to |
T9875 | 18282-18290 | VB | denotes | believed |
T9874 | 18279-18281 | VB | denotes | is |
T9873 | 18275-18278 | NN | denotes | A20 |
T9872 | 18272-18273 | -RRB- | denotes | ) |
T9871 | 18271-18272 | -RRB- | denotes | ] |
T9870 | 18269-18271 | CD | denotes | 37 |
T9869 | 18268-18269 | -LRB- | denotes | [ |
T9868 | 18265-18267 | IN | denotes | in |
T9867 | 18256-18264 | VB | denotes | reviewed |
T9866 | 18255-18256 | -LRB- | denotes | ( |
T9865 | 18246-18254 | NN | denotes | receptor |
T9864 | 18244-18245 | CD | denotes | 2 |
T9863 | 18226-18243 | JJ | denotes | domain-containing |
T9862 | 18210-18225 | NN | denotes | oligomerisation |
T9861 | 18191-18209 | JJ | denotes | nucleotide-binding |
T9860 | 18187-18190 | DT | denotes | the |
T9859 | 18183-18186 | CC | denotes | and |
T9858 | 18178-18182 | NN | denotes | TLRs |
T9857 | 18175-18177 | IN | denotes | of |
T9856 | 18164-18174 | NN | denotes | triggering |
T9855 | 18160-18163 | DT | denotes | the |
T9854 | 18156-18159 | CC | denotes | and |
T9853 | 18154-18155 | -COMMA- | denotes | , |
T9852 | 18146-18154 | NN | denotes | antigens |
T9851 | 18142-18145 | CC | denotes | and |
T9850 | 18137-18141 | NN | denotes | IL-1 |
T9849 | 18135-18136 | -COMMA- | denotes | , |
T9848 | 18132-18135 | NN | denotes | TNF |
T9847 | 18122-18131 | VB | denotes | including |
T9846 | 18120-18121 | -COMMA- | denotes | , |
T9845 | 18113-18120 | NN | denotes | stimuli |
T9844 | 18095-18112 | JJ | denotes | immune-activating |
T9843 | 18085-18094 | JJ | denotes | different |
T9842 | 18082-18084 | TO | denotes | to |
T9841 | 18073-18081 | NN | denotes | response |
T9840 | 18070-18072 | IN | denotes | in |
T9839 | 18059-18069 | NN | denotes | expression |
T9838 | 18054-18058 | NN | denotes | gene |
T9837 | 18038-18053 | JJ | denotes | NF-κB-dependent |
T9836 | 18028-18037 | VB | denotes | regulates |
T9835 | 18017-18027 | RB | denotes | negatively |
T9834 | 18012-18016 | WDT | denotes | that |
T9833 | 18004-18011 | NN | denotes | protein |
T9832 | 17986-18003 | JJ | denotes | ubiquitin-editing |
T9831 | 17984-17985 | DT | denotes | a |
T9830 | 17981-17983 | VB | denotes | is |
T9829 | 17979-17980 | -RRB- | denotes | ) |
T9828 | 17972-17979 | NN | denotes | TNFAIP3 |
T9827 | 17969-17971 | IN | denotes | as |
T9826 | 17963-17968 | VB | denotes | known |
T9825 | 17958-17962 | RB | denotes | also |
T9824 | 17957-17958 | -LRB- | denotes | ( |
T9823 | 17953-17956 | NN | denotes | A20 |
T9822 | 17945-17952 | NN | denotes | protein |
T9821 | 17941-17944 | NN | denotes | A20 |
T10620 | 22858-22863 | NN | denotes | tools |
T10619 | 22849-22857 | JJ | denotes | valuable |
T10618 | 22844-22848 | RB | denotes | very |
T10617 | 22841-22843 | VB | denotes | be |
T10616 | 22836-22840 | MD | denotes | will |
T10615 | 22834-22835 | -COMMA- | denotes | , |
T10614 | 22832-22834 | NN | denotes | RA |
T10613 | 22828-22831 | IN | denotes | for |
T10612 | 22821-22827 | NN | denotes | models |
T10611 | 22815-22820 | NN | denotes | mouse |
T10610 | 22810-22814 | IN | denotes | with |
T10609 | 22801-22809 | VB | denotes | combined |
T10608 | 22799-22800 | -COMMA- | denotes | , |
T10607 | 22795-22799 | NN | denotes | SNPs |
T10606 | 22791-22794 | NN | denotes | A20 |
T10605 | 22777-22790 | VB | denotes | corresponding |
T10604 | 22773-22776 | DT | denotes | the |
T10603 | 22769-22772 | IN | denotes | for |
T10602 | 22764-22768 | NN | denotes | mice |
T10601 | 22756-22763 | JJ | denotes | knockin |
T10600 | 22754-22755 | -COMMA- | denotes | , |
T10599 | 22747-22754 | NN | denotes | context |
T10598 | 22742-22746 | DT | denotes | this |
T10597 | 22739-22741 | IN | denotes | In |
T10596 | 22729-22737 | NN | denotes | variants |
T10595 | 22723-22728 | DT | denotes | these |
T10594 | 22720-22722 | IN | denotes | of |
T10593 | 22707-22719 | NN | denotes | consequences |
T10592 | 22696-22706 | JJ | denotes | functional |
T10591 | 22692-22695 | DT | denotes | the |
T10590 | 22682-22691 | VB | denotes | elucidate |
T10589 | 22679-22681 | TO | denotes | to |
T10588 | 22675-22678 | CC | denotes | and |
T10587 | 22666-22674 | NN | denotes | variants |
T10586 | 22659-22665 | JJ | denotes | causal |
T8558 | 16778-16780 | IN | denotes | of |
T8557 | 16762-16777 | NN | denotes | immunopathology |
T8556 | 16758-16761 | DT | denotes | the |
T8555 | 16755-16757 | IN | denotes | in |
T8554 | 16747-16754 | NN | denotes | factors |
T8553 | 16736-16746 | JJ | denotes | inhibitory |
T8552 | 16730-16735 | NN | denotes | NF-κB |
T8551 | 16724-16729 | DT | denotes | these |
T8550 | 16721-16723 | IN | denotes | of |
T8549 | 16716-16720 | NN | denotes | role |
T8548 | 16706-16715 | JJ | denotes | potential |
T8547 | 16702-16705 | DT | denotes | the |
T8546 | 16694-16701 | VB | denotes | discuss |
T8545 | 16691-16693 | PRP | denotes | we |
T8544 | 16689-16690 | -COMMA- | denotes | , |
T8543 | 16681-16689 | NN | denotes | addition |
T8542 | 16678-16680 | IN | denotes | In |
T8541 | 16672-16676 | NN | denotes | loop |
T8540 | 16663-16671 | NN | denotes | feedback |
T8539 | 16654-16662 | JJ | denotes | negative |
T8538 | 16652-16653 | DT | denotes | a |
T8537 | 16649-16651 | IN | denotes | in |
T8536 | 16642-16648 | VB | denotes | acting |
T8535 | 16637-16641 | RB | denotes | thus |
T8534 | 16633-16636 | CC | denotes | and |
T8533 | 16626-16632 | PRP | denotes | itself |
T8532 | 16620-16625 | NN | denotes | NF-κB |
T8531 | 16617-16619 | IN | denotes | of |
T8530 | 16609-16616 | NN | denotes | control |
T8529 | 16605-16608 | DT | denotes | the |
T8528 | 16599-16604 | IN | denotes | under |
T8527 | 16594-16598 | PRP | denotes | them |
T8526 | 16591-16593 | IN | denotes | of |
T8525 | 16586-16590 | DT | denotes | some |
T8524 | 16584-16585 | -COMMA- | denotes | , |
T8523 | 16576-16584 | NN | denotes | response |
T8522 | 16570-16575 | NN | denotes | NF-κB |
T8521 | 16566-16569 | DT | denotes | the |
T8520 | 16563-16565 | IN | denotes | of |
T8519 | 16551-16562 | NN | denotes | termination |
T8518 | 16548-16550 | CC | denotes | or |
T8517 | 16538-16547 | NN | denotes | dampening |
T8516 | 16534-16537 | DT | denotes | the |
T8515 | 16531-16533 | IN | denotes | in |
T8514 | 16522-16530 | VB | denotes | involved |
T8513 | 16518-16521 | VB | denotes | are |
T8512 | 16513-16517 | WDT | denotes | that |
T8511 | 16504-16512 | NN | denotes | proteins |
T8510 | 16501-16503 | IN | denotes | of |
T8509 | 16494-16500 | NN | denotes | number |
T8508 | 16492-16493 | DT | denotes | a |
T8507 | 16489-16491 | IN | denotes | of |
T8506 | 16480-16488 | NN | denotes | overview |
T8505 | 16477-16479 | DT | denotes | an |
T8504 | 16472-16476 | VB | denotes | give |
T8503 | 16469-16471 | PRP | denotes | we |
T8502 | 16463-16468 | IN | denotes | Below |
T8501 | 16460-16461 | -RRB- | denotes | ] |
T8500 | 16458-16460 | CD | denotes | 32 |
T8499 | 16457-16458 | -LRB- | denotes | [ |
T8498 | 16446-16456 | NN | denotes | signalling |
T8497 | 16440-16445 | NN | denotes | NF-κB |
T8496 | 16427-16439 | VB | denotes | downregulate |
T8495 | 16422-16426 | WDT | denotes | that |
T8494 | 16413-16421 | NN | denotes | proteins |
T8493 | 16402-16412 | JJ | denotes | inhibitory |
T8492 | 16399-16401 | IN | denotes | of |
T8491 | 16388-16398 | NN | denotes | expression |
T8490 | 16384-16387 | DT | denotes | the |
T8489 | 16374-16383 | VB | denotes | including |
T8488 | 16372-16373 | -COMMA- | denotes | , |
T8487 | 16362-16372 | NN | denotes | mechanisms |
T8486 | 16352-16361 | JJ | denotes | different |
T8485 | 16345-16351 | VB | denotes | employ |
T8484 | 16339-16344 | NN | denotes | cells |
T8483 | 16337-16338 | -COMMA- | denotes | , |
T8482 | 16333-16337 | DT | denotes | this |
T8481 | 16325-16332 | VB | denotes | achieve |
T8480 | 16322-16324 | TO | denotes | To |
T8479 | 16307-16320 | NN | denotes | tumorigenesis |
T8478 | 16300-16306 | CC | denotes | and/or |
T8477 | 16287-16299 | NN | denotes | inflammation |
T8476 | 16279-16286 | JJ | denotes | chronic |
T8475 | 16276-16278 | TO | denotes | to |
T8474 | 16271-16275 | VB | denotes | lead |
T8473 | 16267-16270 | MD | denotes | may |
T8472 | 16262-16266 | WDT | denotes | that |
T8471 | 16251-16261 | NN | denotes | activation |
T8470 | 16245-16250 | NN | denotes | NF-κB |
T8469 | 16234-16244 | JJ | denotes | persistent |
T8468 | 16226-16233 | VB | denotes | prevent |
T8467 | 16223-16225 | TO | denotes | to |
T8466 | 16213-16222 | JJ | denotes | essential |
T8465 | 16210-16212 | VB | denotes | is |
T8464 | 16201-16209 | NN | denotes | response |
T8463 | 16195-16200 | NN | denotes | NF-κB |
T8462 | 16192-16194 | DT | denotes | an |
T8461 | 16180-16191 | VB | denotes | terminating |
T8460 | 16178-16179 | -COMMA- | denotes | , |
T8459 | 16170-16178 | RB | denotes | Moreover |
T10585 | 22652-22658 | JJ | denotes | actual |
T10584 | 22648-22651 | DT | denotes | the |
T10583 | 22639-22647 | VB | denotes | identify |
T10582 | 22636-22638 | TO | denotes | to |
T10581 | 22627-22635 | NN | denotes | interest |
T10580 | 22624-22626 | IN | denotes | of |
T10579 | 22621-22623 | VB | denotes | be |
T10578 | 22616-22620 | MD | denotes | will |
T10577 | 22613-22615 | PRP | denotes | It |
T10576 | 22610-22611 | -RRB- | denotes | ] |
T10575 | 22608-22610 | CD | denotes | 53 |
T10574 | 22607-22608 | -LRB- | denotes | [ |
T10573 | 22594-22606 | VB | denotes | investigated |
T10572 | 22589-22593 | NN | denotes | SNPs |
T10571 | 22585-22588 | DT | denotes | the |
T10570 | 22582-22584 | IN | denotes | of |
T10569 | 22577-22581 | DT | denotes | some |
T10568 | 22573-22576 | IN | denotes | for |
T10567 | 22559-22572 | NN | denotes | transcription |
T10566 | 22555-22558 | NN | denotes | A20 |
T10565 | 22545-22554 | VB | denotes | repressed |
T10564 | 22540-22544 | VB | denotes | show |
T10563 | 22534-22539 | MD | denotes | could |
T10562 | 22530-22533 | CC | denotes | and |
T10561 | 22528-22529 | -COMMA- | denotes | , |
T10560 | 22520-22528 | NN | denotes | activity |
T10559 | 22511-22519 | NN | denotes | promoter |
T10558 | 22507-22510 | NN | denotes | A20 |
T10557 | 22504-22506 | IN | denotes | on |
T10556 | 22495-22503 | NN | denotes | variants |
T10555 | 22491-22494 | NN | denotes | SNP |
T10554 | 22477-22490 | JJ | denotes | RA-associated |
T10553 | 22474-22476 | IN | denotes | of |
T10552 | 22466-22473 | NN | denotes | ability |
T10551 | 22455-22465 | JJ | denotes | regulatory |
T10550 | 22451-22454 | DT | denotes | the |
T10549 | 22445-22450 | FW | denotes | vitro |
T10548 | 22442-22444 | FW | denotes | in |
T10547 | 22432-22441 | VB | denotes | evaluated |
T10546 | 22419-22431 | RB | denotes | functionally |
T10545 | 22408-22418 | NN | denotes | colleagues |
T10544 | 22404-22407 | CC | denotes | and |
T10543 | 22398-22403 | NNP | denotes | Elsby |
T10542 | 22396-22397 | -COMMA- | denotes | , |
T10541 | 22388-22396 | RB | denotes | Recently |
T10540 | 22379-22386 | JJ | denotes | unclear |
T10539 | 22372-22378 | VB | denotes | remain |
T10538 | 22370-22371 | -COMMA- | denotes | , |
T10537 | 22363-22370 | RB | denotes | however |
T10536 | 22361-22362 | -COMMA- | denotes | , |
T10535 | 22359-22361 | NN | denotes | RA |
T10534 | 22353-22358 | VB | denotes | cause |
T10533 | 22348-22352 | PRP | denotes | they |
T10532 | 22344-22347 | WRB | denotes | how |
T10531 | 22340-22343 | CC | denotes | and |
T10530 | 22331-22339 | NN | denotes | activity |
T10529 | 22327-22330 | NN | denotes | A20 |
T10528 | 22320-22326 | JJ | denotes | normal |
T10527 | 22313-22319 | VB | denotes | affect |
T10526 | 22304-22312 | NN | denotes | variants |
T10525 | 22298-22303 | DT | denotes | these |
T10524 | 22294-22297 | WRB | denotes | How |
T10523 | 22290-22292 | NN | denotes | RA |
T10522 | 22286-22289 | IN | denotes | for |
T10521 | 22280-22285 | NN | denotes | locus |
T10520 | 22265-22279 | NN | denotes | susceptibility |
T10519 | 22255-22264 | NN | denotes | candidate |
T10518 | 22253-22254 | DT | denotes | a |
T10517 | 22250-22252 | IN | denotes | as |
T10516 | 22246-22249 | NN | denotes | A20 |
T10515 | 22239-22245 | VB | denotes | reveal |
T10514 | 22230-22238 | NN | denotes | findings |
T10513 | 22224-22229 | DT | denotes | these |
T10512 | 22222-22223 | -COMMA- | denotes | , |
T10511 | 22220-22222 | NN | denotes | RA |
T10510 | 22217-22219 | IN | denotes | in |
T10509 | 22208-22216 | NN | denotes | cytokine |
T10508 | 22195-22207 | JJ | denotes | inflammatory |
T10507 | 22187-22194 | JJ | denotes | primary |
T10506 | 22183-22186 | DT | denotes | the |
T10505 | 22180-22182 | VB | denotes | is |
T10504 | 22176-22179 | NN | denotes | TNF |
T10503 | 22172-22175 | CC | denotes | and |
T10502 | 22170-22171 | -COMMA- | denotes | , |
T10501 | 22163-22170 | NN | denotes | signals |
T10500 | 22151-22162 | JJ | denotes | TNF-induced |
T10499 | 22148-22150 | IN | denotes | of |
T10498 | 22136-22147 | NN | denotes | termination |
T10497 | 22132-22135 | IN | denotes | for |
T10496 | 22123-22131 | VB | denotes | required |
T10495 | 22120-22122 | VB | denotes | is |
T10494 | 22116-22119 | NN | denotes | A20 |
T10493 | 22113-22115 | IN | denotes | As |
T10492 | 22105-22111 | NN | denotes | region |
T10491 | 22100-22104 | DT | denotes | this |
T10490 | 22097-22099 | IN | denotes | in |
T10489 | 22088-22096 | NN | denotes | elements |
T10488 | 22084-22087 | NN | denotes | DNA |
T10487 | 22073-22083 | JJ | denotes | regulatory |
T10486 | 22063-22072 | JJ | denotes | potential |
T10485 | 22060-22062 | IN | denotes | of |
T10484 | 22051-22059 | NN | denotes | presence |
T10483 | 22047-22050 | DT | denotes | the |
T10482 | 22044-22046 | IN | denotes | by |
T10481 | 22035-22043 | RB | denotes | probably |
T10480 | 22033-22034 | -COMMA- | denotes | , |
T10479 | 22032-22033 | -RRB- | denotes | ) |
T10478 | 22029-22032 | NN | denotes | A20 |
T10477 | 22026-22028 | IN | denotes | of |
T10476 | 22015-22025 | RB | denotes | downstream |
T10475 | 22012-22014 | NN | denotes | kb |
T10474 | 22007-22011 | CD | denotes | ~150 |
T10473 | 22006-22007 | -LRB- | denotes | ( |
T10472 | 22001-22005 | NN | denotes | gene |
T10471 | 21993-22000 | JJ | denotes | nearest |
T10470 | 21989-21992 | PRP-DOLLAR- | denotes | its |
T10469 | 21986-21988 | IN | denotes | as |
T10468 | 21982-21985 | NN | denotes | A20 |
T10467 | 21972-21981 | VB | denotes | influence |
T10466 | 21969-21971 | TO | denotes | to |
T10465 | 21961-21968 | VB | denotes | thought |
T10464 | 21957-21960 | VB | denotes | are |
T10463 | 21952-21956 | PRP | denotes | they |
T10462 | 21950-21951 | -COMMA- | denotes | , |
T10025 | 19191-19194 | CC | denotes | and |
T10024 | 19178-19190 | NN | denotes | inflammation |
T10023 | 19167-19177 | JJ | denotes | multiorgan |
T10022 | 19159-19166 | VB | denotes | develop |
T10021 | 19145-19158 | RB | denotes | spontaneously |
T10020 | 19140-19144 | NN | denotes | mice |
T10019 | 19126-19139 | JJ | denotes | A20-deficient |
T10018 | 19117-19124 | JJ | denotes | elusive |
T10017 | 19111-19116 | RB | denotes | still |
T10016 | 19107-19110 | VB | denotes | are |
T10015 | 19105-19106 | -COMMA- | denotes | , |
T10014 | 19098-19105 | RB | denotes | however |
T10013 | 19096-19097 | -COMMA- | denotes | , |
T10012 | 19086-19096 | NN | denotes | signalling |
T10011 | 19076-19085 | JJ | denotes | apoptotic |
T10010 | 19066-19075 | VB | denotes | regulates |
T10009 | 19062-19065 | NN | denotes | A20 |
T10008 | 19056-19061 | WDT | denotes | which |
T10007 | 19053-19055 | IN | denotes | by |
T10006 | 19042-19052 | NN | denotes | mechanisms |
T10005 | 19038-19041 | DT | denotes | The |
T10004 | 19031-19036 | NN | denotes | types |
T10003 | 19026-19030 | NN | denotes | cell |
T10002 | 19021-19025 | DT | denotes | some |
T10001 | 19018-19020 | IN | denotes | in |
T10000 | 19012-19017 | JJ | denotes | least |
T9999 | 19009-19011 | IN | denotes | at |
T9998 | 19007-19008 | -COMMA- | denotes | , |
T9997 | 18998-19007 | NN | denotes | apoptosis |
T9996 | 18995-18997 | IN | denotes | of |
T9995 | 18985-18994 | NN | denotes | inhibitor |
T9994 | 18978-18984 | JJ | denotes | strong |
T9993 | 18976-18977 | DT | denotes | a |
T9992 | 18971-18975 | RB | denotes | also |
T9991 | 18968-18970 | VB | denotes | is |
T9990 | 18964-18967 | NN | denotes | A20 |
T9989 | 18962-18963 | -COMMA- | denotes | , |
T9988 | 18952-18962 | NN | denotes | activation |
T9987 | 18946-18951 | NN | denotes | NF-κB |
T9986 | 18934-18945 | VB | denotes | suppressing |
T9985 | 18931-18933 | IN | denotes | in |
T9984 | 18926-18930 | NN | denotes | role |
T9983 | 18922-18925 | PRP-DOLLAR- | denotes | its |
T9982 | 18919-18921 | TO | denotes | to |
T9981 | 18914-18918 | JJ | denotes | Next |
T9980 | 18911-18912 | -RRB- | denotes | ] |
T9979 | 18906-18911 | CD | denotes | 43-46 |
T9978 | 18905-18906 | -LRB- | denotes | [ |
T9977 | 18903-18904 | CD | denotes | 1 |
T8458 | 16160-16168 | NN | denotes | response |
T8457 | 16147-16159 | JJ | denotes | inflammatory |
T8456 | 16143-16146 | DT | denotes | the |
T8455 | 16133-16142 | VB | denotes | fine-tune |
T8454 | 16130-16132 | TO | denotes | to |
T8453 | 16118-16129 | NN | denotes | requirement |
T8452 | 16109-16117 | JJ | denotes | absolute |
T8451 | 16106-16108 | DT | denotes | an |
T8450 | 16103-16105 | VB | denotes | is |
T8449 | 16095-16102 | VB | denotes | induces |
T8448 | 16092-16094 | PRP | denotes | it |
T8447 | 16086-16091 | NN | denotes | genes |
T8446 | 16082-16085 | DT | denotes | the |
T8445 | 16078-16081 | CC | denotes | and |
T8444 | 16070-16077 | NN | denotes | pathway |
T8443 | 16059-16069 | NN | denotes | signalling |
T8442 | 16053-16058 | NN | denotes | NF-κB |
T8441 | 16049-16052 | DT | denotes | the |
T8440 | 16046-16048 | IN | denotes | of |
T8439 | 16035-16045 | NN | denotes | regulation |
T8438 | 16029-16034 | JJ | denotes | tight |
T8437 | 16027-16028 | DT | denotes | a |
T8436 | 16025-16026 | -COMMA- | denotes | , |
T8435 | 16016-16025 | NN | denotes | processes |
T8434 | 16007-16015 | JJ | denotes | cellular |
T8433 | 16002-16006 | JJ | denotes | many |
T8432 | 15999-16001 | TO | denotes | to |
T8431 | 15991-15998 | JJ | denotes | crucial |
T8430 | 15988-15990 | RB | denotes | so |
T8429 | 15985-15987 | VB | denotes | is |
T8428 | 15974-15984 | NN | denotes | activation |
T8427 | 15968-15973 | NN | denotes | NF-κB |
T8426 | 15962-15967 | IN | denotes | Since |
T10461 | 21946-21950 | NN | denotes | gene |
T10460 | 21944-21945 | DT | denotes | a |
T10459 | 21941-21943 | IN | denotes | in |
T10458 | 21933-21940 | VB | denotes | located |
T10457 | 21929-21932 | RB | denotes | not |
T10456 | 21925-21928 | VB | denotes | are |
T10455 | 21916-21924 | NN | denotes | variants |
T10454 | 21905-21915 | VB | denotes | identified |
T10453 | 21901-21904 | DT | denotes | the |
T10452 | 21892-21900 | IN | denotes | Although |
T10451 | 21889-21890 | -RRB- | denotes | ] |
T10450 | 21887-21889 | CD | denotes | 52 |
T10449 | 21886-21887 | -LRB- | denotes | [ |
T10448 | 21883-21885 | NN | denotes | RA |
T10447 | 21880-21882 | TO | denotes | to |
T10446 | 21865-21879 | NN | denotes | susceptibility |
T10445 | 21861-21864 | CC | denotes | and |
T10444 | 21850-21860 | NN | denotes | chromosome |
T10037 | 19254-19260 | JJ | denotes | potent |
T10036 | 19250-19253 | DT | denotes | the |
T10035 | 19237-19249 | VB | denotes | illustrating |
T10034 | 19235-19236 | -COMMA- | denotes | , |
T10033 | 19230-19235 | NN | denotes | birth |
T10032 | 19227-19229 | IN | denotes | of |
T10031 | 19221-19226 | NN | denotes | weeks |
T10030 | 19219-19220 | CD | denotes | 2 |
T10029 | 19212-19218 | IN | denotes | within |
T10028 | 19208-19211 | VB | denotes | die |
T10027 | 19204-19207 | CC | denotes | and |
T10026 | 19195-19203 | NN | denotes | cachexia |
T8741 | 17936-17938 | NN | denotes | RA |
T8740 | 17931-17935 | IN | denotes | like |
T8739 | 17922-17930 | NN | denotes | diseases |
T8738 | 17909-17921 | JJ | denotes | inflammatory |
T8737 | 17901-17908 | JJ | denotes | chronic |
T8736 | 17897-17900 | IN | denotes | for |
T8735 | 17884-17896 | NN | denotes | implications |
T8734 | 17875-17883 | JJ | denotes | possible |
T8733 | 17870-17874 | IN | denotes | with |
T8732 | 17861-17869 | NN | denotes | pathways |
T8731 | 17855-17860 | NN | denotes | NF-κB |
T8730 | 17842-17854 | JJ | denotes | noncanonical |
T8729 | 17838-17841 | CC | denotes | and |
T8728 | 17828-17837 | JJ | denotes | canonical |
T8727 | 17823-17827 | CC | denotes | both |
T8726 | 17811-17822 | VB | denotes | terminating |
T8725 | 17808-17810 | IN | denotes | in |
T8724 | 17802-17807 | NN | denotes | roles |
T8723 | 17792-17801 | JJ | denotes | important |
T8722 | 17786-17791 | VB | denotes | plays |
T8721 | 17781-17785 | NN | denotes | IKK1 |
T8720 | 17776-17780 | IN | denotes | that |
T8719 | 17771-17775 | NN | denotes | idea |
T8718 | 17767-17770 | DT | denotes | the |
T8717 | 17756-17766 | VB | denotes | supporting |
T8716 | 17754-17755 | -COMMA- | denotes | , |
T8715 | 17753-17754 | -RRB- | denotes | ] |
T8714 | 17751-17753 | CD | denotes | 36 |
T8713 | 17750-17751 | -LRB- | denotes | [ |
T8712 | 17742-17749 | NN | denotes | pathway |
T8711 | 17736-17741 | NN | denotes | NF-κB |
T8710 | 17723-17735 | JJ | denotes | noncanonical |
T8709 | 17719-17722 | DT | denotes | the |
T8708 | 17716-17718 | IN | denotes | of |
T8707 | 17705-17715 | NN | denotes | regulation |
T8706 | 17696-17704 | NN | denotes | feedback |
T8705 | 17687-17695 | JJ | denotes | negative |
T8704 | 17684-17686 | IN | denotes | in |
T8703 | 17680-17683 | NN | denotes | NIK |
T8702 | 17665-17679 | VB | denotes | phosphorylates |
T8701 | 17660-17664 | NN | denotes | IKK1 |
T8700 | 17655-17659 | IN | denotes | that |
T8699 | 17642-17654 | VB | denotes | demonstrated |
T8698 | 17638-17641 | VB | denotes | has |
T8697 | 17632-17637 | NN | denotes | study |
T8696 | 17625-17631 | JJ | denotes | recent |
T8695 | 17623-17624 | DT | denotes | a |
T8694 | 17621-17622 | -COMMA- | denotes | , |
T8693 | 17608-17621 | RB | denotes | Interestingly |
T8692 | 17605-17606 | -RRB- | denotes | ] |
T8691 | 17603-17605 | CD | denotes | 35 |
T8690 | 17602-17603 | -LRB- | denotes | [ |
T8689 | 17596-17601 | NN | denotes | STAT1 |
T8688 | 17580-17595 | VB | denotes | phosphorylating |
T8687 | 17577-17579 | IN | denotes | by |
T8686 | 17566-17576 | NN | denotes | signalling |
T8685 | 17550-17565 | JJ | denotes | proinflammatory |
T8684 | 17537-17549 | VB | denotes | downregulate |
T8683 | 17534-17536 | TO | denotes | to |
T8682 | 17530-17533 | CC | denotes | and |
T8681 | 17524-17529 | NN | denotes | NF-κB |
T8680 | 17516-17523 | JJ | denotes | nuclear |
T8679 | 17508-17515 | VB | denotes | inhibit |
T8678 | 17505-17507 | TO | denotes | to |
T8677 | 17499-17504 | VB | denotes | shown |
T8676 | 17494-17498 | VB | denotes | been |
T8675 | 17489-17493 | RB | denotes | also |
T8674 | 17485-17488 | VB | denotes | has |
T8673 | 17480-17484 | NN | denotes | IKK1 |
T8672 | 17477-17478 | -RRB- | denotes | ] |
T8671 | 17475-17477 | CD | denotes | 34 |
T8670 | 17474-17475 | -LRB- | denotes | [ |
T8669 | 17462-17473 | NN | denotes | degradation |
T8668 | 17457-17461 | NN | denotes | IκBα |
T8667 | 17453-17456 | CC | denotes | and |
T8666 | 17442-17452 | NN | denotes | activation |
T8665 | 17437-17441 | NN | denotes | IKK2 |
T8664 | 17428-17436 | VB | denotes | enhanced |
T8663 | 17425-17427 | IN | denotes | of |
T8662 | 17418-17424 | NN | denotes | result |
T8661 | 17416-17417 | DT | denotes | a |
T8660 | 17413-17415 | IN | denotes | as |
T8659 | 17403-17412 | NN | denotes | cytokines |
T8658 | 17387-17402 | JJ | denotes | proinflammatory |
T8657 | 17384-17386 | IN | denotes | of |
T8656 | 17373-17383 | NN | denotes | production |
T8655 | 17363-17372 | VB | denotes | increased |
T8654 | 17358-17362 | VB | denotes | show |
T8653 | 17353-17357 | NN | denotes | IKK1 |
T8652 | 17344-17352 | JJ | denotes | inactive |
T8651 | 17333-17343 | VB | denotes | expressing |
T8650 | 17328-17332 | NN | denotes | mice |
T8649 | 17320-17327 | JJ | denotes | knockin |
T8648 | 17317-17319 | CC | denotes | or |
T8647 | 17312-17316 | NN | denotes | mice |
T8646 | 17297-17311 | JJ | denotes | IKK1-deficient |
T8645 | 17292-17296 | IN | denotes | from |
T8644 | 17280-17291 | NN | denotes | Macrophages |
T8643 | 17270-17278 | NN | denotes | pathways |
T8642 | 17264-17269 | NN | denotes | NF-κB |
T8641 | 17251-17263 | JJ | denotes | noncanonical |
T8640 | 17247-17250 | CC | denotes | and |
T8639 | 17237-17246 | JJ | denotes | canonical |
T8638 | 17232-17236 | CC | denotes | both |
T8637 | 17229-17231 | IN | denotes | of |
T8636 | 17218-17228 | NN | denotes | regulation |
T8635 | 17209-17217 | JJ | denotes | negative |
T8634 | 17205-17208 | DT | denotes | the |
T8633 | 17202-17204 | IN | denotes | in |
T8632 | 17197-17201 | NN | denotes | role |
T8631 | 17187-17196 | JJ | denotes | prominent |
T8630 | 17185-17186 | DT | denotes | a |
T8629 | 17179-17184 | VB | denotes | plays |
T8628 | 17174-17178 | RB | denotes | also |
T8627 | 17167-17173 | NN | denotes | kinase |
T8626 | 17162-17166 | DT | denotes | this |
T8625 | 17157-17161 | IN | denotes | that |
T8624 | 17147-17156 | VB | denotes | mentioned |
T8623 | 17144-17146 | VB | denotes | be |
T8622 | 17137-17143 | MD | denotes | should |
T8621 | 17134-17136 | PRP | denotes | it |
T8620 | 17132-17133 | -COMMA- | denotes | , |
T8619 | 17125-17132 | NN | denotes | pathway |
T8618 | 17119-17124 | NN | denotes | NF-κB |
T8617 | 17105-17118 | JJ | denotes | non-canonical |
T8616 | 17101-17104 | DT | denotes | the |
T8615 | 17098-17100 | IN | denotes | of |
T8614 | 17088-17097 | NN | denotes | component |
T8613 | 17079-17087 | JJ | denotes | critical |
T8612 | 17077-17078 | DT | denotes | a |
T8611 | 17074-17076 | VB | denotes | is |
T8610 | 17069-17073 | NN | denotes | IKK1 |
T8609 | 17050-17068 | IN | denotes | reported. Although |
T8608 | 17045-17049 | VB | denotes | been |
T8607 | 17041-17044 | RB | denotes | yet |
T8606 | 17037-17040 | RB | denotes | not |
T8605 | 17033-17036 | VB | denotes | has |
T8604 | 17023-17032 | NN | denotes | pathology |
T8603 | 17020-17022 | NN | denotes | RA |
T8602 | 17015-17019 | IN | denotes | with |
T8601 | 17010-17014 | NN | denotes | link |
T8600 | 17008-17009 | DT | denotes | a |
T8599 | 17002-17007 | IN | denotes | since |
T8598 | 17000-17001 | -COMMA- | denotes | , |
T8597 | 16996-17000 | RB | denotes | here |
T8596 | 16986-16995 | VB | denotes | discussed |
T8595 | 16982-16985 | RB | denotes | not |
T8594 | 16978-16981 | VB | denotes | are |
T8593 | 16969-16977 | NN | denotes | proteins |
T8592 | 16963-16968 | DT | denotes | These |
T8591 | 16960-16961 | -RRB- | denotes | ) |
T8590 | 16959-16960 | -RRB- | denotes | ] |
T8589 | 16957-16959 | CD | denotes | 33 |
T8588 | 16956-16957 | -LRB- | denotes | [ |
T8587 | 16953-16955 | IN | denotes | in |
T8586 | 16944-16952 | VB | denotes | reviewed |
T8585 | 16943-16944 | -LRB- | denotes | ( |
T8584 | 16933-16942 | VB | denotes | described |
T8583 | 16928-16932 | VB | denotes | been |
T8582 | 16923-16927 | VB | denotes | have |
T8581 | 16921-16922 | -COMMA- | denotes | , |
T8580 | 16915-16921 | NN | denotes | TOLLIP |
T8579 | 16911-16914 | CC | denotes | and |
T8578 | 16909-16910 | -COMMA- | denotes | , |
T8577 | 16903-16909 | NN | denotes | IRAK-M |
T8576 | 16901-16902 | -COMMA- | denotes | , |
T8575 | 16895-16901 | NN | denotes | MyD88s |
T8574 | 16892-16894 | IN | denotes | as |
T8573 | 16887-16891 | JJ | denotes | such |
T8572 | 16885-16886 | -COMMA- | denotes | , |
T8571 | 16876-16885 | NN | denotes | responses |
T8570 | 16863-16875 | JJ | denotes | inflammatory |
T8569 | 16847-16862 | JJ | denotes | NF-κB-dependent |
T8568 | 16844-16846 | IN | denotes | of |
T8567 | 16833-16843 | NN | denotes | regulation |
T8566 | 16824-16832 | JJ | denotes | negative |
T8565 | 16820-16823 | DT | denotes | the |
T8564 | 16817-16819 | IN | denotes | in |
T8563 | 16808-16816 | VB | denotes | involved |
T8562 | 16799-16807 | NN | denotes | proteins |
T8561 | 16793-16798 | JJ | denotes | other |
T8560 | 16785-16792 | JJ | denotes | Several |
T8559 | 16781-16783 | NN | denotes | RA |
T5414 | 15456-15461 | VB | denotes | leads |
T5413 | 15451-15455 | DT | denotes | this |
T5412 | 15447-15450 | CC | denotes | and |
T5411 | 15445-15446 | -COMMA- | denotes | , |
T5410 | 15440-15445 | NN | denotes | TRAF6 |
T5409 | 15436-15439 | CC | denotes | and |
T5408 | 15434-15435 | -COMMA- | denotes | , |
T5407 | 15429-15434 | NN | denotes | TRAF5 |
T5406 | 15427-15428 | -COMMA- | denotes | , |
T5405 | 15422-15427 | NN | denotes | TRAF3 |
T5404 | 15420-15421 | -COMMA- | denotes | , |
T5403 | 15415-15420 | NN | denotes | TRAF2 |
T5402 | 15413-15414 | -COMMA- | denotes | , |
T5401 | 15408-15413 | NN | denotes | TRAF1 |
T5400 | 15398-15407 | VB | denotes | including |
T5399 | 15396-15397 | -COMMA- | denotes | , |
T5398 | 15389-15396 | NN | denotes | members |
T5397 | 15384-15388 | NN | denotes | TRAF |
T5396 | 15376-15383 | JJ | denotes | several |
T5395 | 15371-15375 | IN | denotes | with |
T5394 | 15362-15370 | VB | denotes | interact |
T5393 | 15357-15361 | NN | denotes | RANK |
T5392 | 15353-15356 | CC | denotes | and |
T5391 | 15348-15352 | NN | denotes | CD40 |
T5390 | 15346-15347 | -COMMA- | denotes | , |
T5389 | 15340-15346 | NN | denotes | ligand |
T5388 | 15334-15339 | PRP-DOLLAR- | denotes | their |
T5387 | 15331-15333 | IN | denotes | of |
T5386 | 15323-15330 | NN | denotes | binding |
T5385 | 15318-15322 | IN | denotes | Upon |
T5384 | 15308-15316 | NN | denotes | pathways |
T5383 | 15297-15307 | NN | denotes | signalling |
T5382 | 15291-15296 | NN | denotes | NF-κB |
T5381 | 15278-15290 | JJ | denotes | noncanonical |
T5380 | 15274-15277 | CC | denotes | and |
T5379 | 15264-15273 | JJ | denotes | canonical |
T5378 | 15259-15263 | CC | denotes | both |
T5377 | 15256-15258 | IN | denotes | of |
T5376 | 15245-15255 | NN | denotes | activation |
T5375 | 15241-15244 | DT | denotes | the |
T5374 | 15233-15240 | VB | denotes | mediate |
T5373 | 15228-15232 | NN | denotes | RANK |
T5372 | 15224-15227 | CC | denotes | and |
T5371 | 15215-15223 | NN | denotes | receptor |
T5370 | 15213-15214 | NN | denotes | β |
T5369 | 15201-15212 | NN | denotes | lymphotoxin |
T5368 | 15199-15200 | -COMMA- | denotes | , |
T5367 | 15195-15199 | NN | denotes | CD40 |
T5366 | 15190-15194 | IN | denotes | that |
T5365 | 15180-15189 | VB | denotes | mentioned |
T5364 | 15177-15179 | VB | denotes | be |
T5363 | 15170-15176 | MD | denotes | should |
T5362 | 15167-15169 | PRP | denotes | It |
T5361 | 13836-13837 | -RRB- | denotes | ) |
T5360 | 13835-13836 | CD | denotes | 2 |
T5359 | 13828-13834 | NN | denotes | Figure |
T5358 | 13827-13828 | -LRB- | denotes | ( |
T5357 | 13825-13826 | -RRB- | denotes | ] |
T5356 | 13820-13825 | CD | denotes | 28,29 |
T5355 | 13819-13820 | -LRB- | denotes | [ |
T5354 | 13803-13818 | NN | denotes | phosphorylation |
T5353 | 13798-13802 | NN | denotes | IKK1 |
T5352 | 13794-13797 | CC | denotes | and |
T5351 | 13781-13793 | NN | denotes | accumulation |
T5350 | 13777-13780 | NN | denotes | NIK |
T5349 | 13774-13776 | IN | denotes | in |
T5348 | 13764-13773 | VB | denotes | resulting |
T5347 | 13762-13763 | -COMMA- | denotes | , |
T5346 | 13751-13762 | NN | denotes | degradation |
T5345 | 13738-13750 | JJ | denotes | constitutive |
T5344 | 13734-13737 | PRP-DOLLAR- | denotes | its |
T5343 | 13729-13733 | IN | denotes | from |
T5342 | 13725-13728 | NN | denotes | NIK |
T5341 | 13715-13724 | VB | denotes | releasing |
T5340 | 13712-13714 | TO | denotes | to |
T5339 | 13700-13711 | VB | denotes | contributes |
T5338 | 13695-13699 | DT | denotes | this |
T5337 | 13691-13694 | PDT | denotes | All |
T5336 | 13678-13689 | NN | denotes | degradation |
T5335 | 13672-13677 | NN | denotes | TRAF3 |
T5334 | 13661-13671 | JJ | denotes | subsequent |
T5333 | 13657-13660 | IN | denotes | for |
T5332 | 13647-13656 | JJ | denotes | essential |
T5331 | 13643-13646 | VB | denotes | are |
T5330 | 13637-13642 | WDT | denotes | which |
T5329 | 13635-13636 | -COMMA- | denotes | , |
T5328 | 13628-13635 | NN | denotes | cIAP1/2 |
T5327 | 13624-13627 | CC | denotes | and |
T5326 | 13618-13623 | NN | denotes | TRAF2 |
T5325 | 13610-13617 | VB | denotes | attract |
T5324 | 13607-13609 | TO | denotes | to |
T5323 | 13602-13606 | RB | denotes | also |
T5322 | 13598-13601 | CC | denotes | but |
T5321 | 13596-13597 | -COMMA- | denotes | , |
T5320 | 13588-13596 | NN | denotes | receptor |
T5319 | 13584-13587 | DT | denotes | the |
T5318 | 13581-13583 | TO | denotes | to |
T5317 | 13578-13580 | PRP | denotes | it |
T5316 | 13567-13577 | VB | denotes | recruiting |
T5315 | 13564-13566 | IN | denotes | by |
T5314 | 13556-13563 | NN | denotes | complex |
T5313 | 13551-13555 | DT | denotes | this |
T5312 | 13546-13550 | IN | denotes | from |
T5311 | 13540-13545 | NN | denotes | TRAF3 |
T5310 | 13533-13539 | VB | denotes | remove |
T5309 | 13530-13532 | TO | denotes | to |
T5308 | 13525-13529 | RB | denotes | only |
T5307 | 13521-13524 | RB | denotes | not |
T5306 | 13515-13520 | VB | denotes | shown |
T5305 | 13510-13514 | VB | denotes | been |
T5304 | 13506-13509 | VB | denotes | has |
T5303 | 13497-13505 | NN | denotes | ligation |
T5302 | 13488-13496 | NN | denotes | Receptor |
T5301 | 13476-13486 | NN | denotes | proteasome |
T5300 | 13472-13475 | DT | denotes | the |
T5299 | 13469-13471 | IN | denotes | by |
T5298 | 13457-13468 | NN | denotes | degradation |
T5297 | 13446-13456 | JJ | denotes | continuous |
T5296 | 13442-13445 | PRP-DOLLAR- | denotes | its |
T5295 | 13439-13441 | TO | denotes | to |
T5294 | 13431-13438 | VB | denotes | leading |
T5293 | 13429-13430 | -COMMA- | denotes | , |
T5292 | 13426-13429 | NN | denotes | NIK |
T5291 | 13404-13425 | VB | denotes | K48-polyubiquitinates |
T5290 | 13398-13403 | WDT | denotes | which |
T5289 | 13396-13397 | -COMMA- | denotes | , |
T5288 | 13389-13396 | NN | denotes | cIAP1/2 |
T5287 | 13385-13388 | CC | denotes | and |
T5286 | 13383-13384 | -COMMA- | denotes | , |
T5285 | 13378-13383 | NN | denotes | TRAF3 |
T5284 | 13376-13377 | -COMMA- | denotes | , |
T5283 | 13371-13376 | NN | denotes | TRAF2 |
T5282 | 13366-13370 | IN | denotes | with |
T5281 | 13358-13365 | NN | denotes | complex |
T5280 | 13346-13357 | JJ | denotes | cytoplasmic |
T5279 | 13344-13345 | DT | denotes | a |
T5278 | 13341-13343 | IN | denotes | in |
T5277 | 13334-13340 | VB | denotes | occurs |
T5276 | 13330-13333 | NN | denotes | NIK |
T5275 | 13328-13329 | -COMMA- | denotes | , |
T5274 | 13323-13328 | NN | denotes | cells |
T5273 | 13310-13322 | JJ | denotes | unstimulated |
T5272 | 13307-13309 | IN | denotes | In |
T5271 | 13300-13305 | NN | denotes | types |
T5270 | 13295-13299 | NN | denotes | cell |
T5269 | 13290-13294 | JJ | denotes | most |
T5268 | 13287-13289 | IN | denotes | in |
T5267 | 13280-13286 | NN | denotes | levels |
T5266 | 13276-13279 | JJ | denotes | low |
T5265 | 13266-13275 | RB | denotes | extremely |
T5264 | 13263-13265 | IN | denotes | at |
T5263 | 13255-13262 | JJ | denotes | present |
T5262 | 13252-13254 | VB | denotes | is |
T5261 | 13248-13251 | CC | denotes | and |
T5260 | 13242-13247 | NN | denotes | level |
T5259 | 13223-13241 | JJ | denotes | post-translational |
T5258 | 13219-13222 | DT | denotes | the |
T5257 | 13216-13218 | IN | denotes | at |
T5256 | 13206-13215 | VB | denotes | regulated |
T5255 | 13192-13205 | RB | denotes | predominantly |
T5254 | 13189-13191 | VB | denotes | is |
T5253 | 13185-13188 | NN | denotes | NIK |
T5252 | 13182-13183 | -RRB- | denotes | ) |
T5251 | 13179-13182 | NN | denotes | NIK |
T5250 | 13178-13179 | -LRB- | denotes | ( |
T5249 | 13171-13177 | NN | denotes | kinase |
T5248 | 13162-13170 | VB | denotes | inducing |
T5247 | 13156-13161 | NN | denotes | NF-κB |
T5246 | 13153-13155 | IN | denotes | by |
T5245 | 13137-13152 | NN | denotes | phosphorylation |
T5244 | 13132-13136 | IN | denotes | upon |
T5243 | 13122-13131 | VB | denotes | activated |
T5242 | 13119-13121 | VB | denotes | is |
T5241 | 13113-13118 | WDT | denotes | which |
T5240 | 13111-13112 | -COMMA- | denotes | , |
T5239 | 13107-13111 | NN | denotes | IKK1 |
T5238 | 13104-13106 | IN | denotes | on |
T5237 | 13094-13103 | JJ | denotes | dependent |
T5236 | 13085-13093 | RB | denotes | strictly |
T5235 | 13082-13084 | VB | denotes | is |
T5234 | 13074-13081 | NN | denotes | pathway |
T5233 | 13068-13073 | NN | denotes | NF-κB |
T5232 | 13055-13067 | JJ | denotes | noncanonical |
T5231 | 13051-13054 | DT | denotes | The |
T5230 | 13049-13050 | -RRB- | denotes | ] |
T5229 | 13047-13049 | CD | denotes | 27 |
T5228 | 13046-13047 | -LRB- | denotes | [ |
T5227 | 13027-13045 | NN | denotes | osteoclastogenesis |
T5226 | 13023-13026 | CC | denotes | and |
T5225 | 13021-13022 | -COMMA- | denotes | , |
T5224 | 13010-13021 | NN | denotes | development |
T5223 | 13004-13009 | NN | denotes | organ |
T5222 | 12995-13003 | JJ | denotes | lymphoid |
T5221 | 12985-12994 | JJ | denotes | secondary |
T5220 | 12983-12984 | -COMMA- | denotes | , |
T5219 | 12972-12983 | NN | denotes | development |
T5218 | 12965-12971 | NN | denotes | B-cell |
T5217 | 12957-12964 | VB | denotes | control |
T5216 | 12952-12956 | WDT | denotes | that |
T5215 | 12946-12951 | NN | denotes | genes |
T5214 | 12939-12945 | NN | denotes | target |
T5213 | 12936-12938 | IN | denotes | of |
T5212 | 12932-12935 | NN | denotes | set |
T5211 | 12923-12931 | JJ | denotes | distinct |
T5210 | 12921-12922 | DT | denotes | a |
T5209 | 12911-12920 | VB | denotes | regulates |
T5208 | 12903-12910 | NN | denotes | subunit |
T5207 | 12897-12902 | NN | denotes | NF-κB |
T5206 | 12892-12896 | NN | denotes | RelB |
T5205 | 12888-12891 | DT | denotes | the |
T5204 | 12883-12887 | IN | denotes | with |
T5203 | 12874-12882 | RB | denotes | together |
T5202 | 12868-12873 | WDT | denotes | which |
T5201 | 12866-12867 | -COMMA- | denotes | , |
T5200 | 12863-12866 | NN | denotes | p52 |
T5199 | 12860-12862 | TO | denotes | to |
T4953 | 11368-11375 | JJ | denotes | unclear |
T4952 | 11362-11367 | RB | denotes | still |
T4951 | 11359-11361 | VB | denotes | is |
T4950 | 11354-11358 | DT | denotes | each |
T4949 | 11351-11353 | IN | denotes | of |
T4948 | 11346-11350 | NN | denotes | role |
T4947 | 11337-11345 | JJ | denotes | specific |
T4946 | 11333-11336 | DT | denotes | the |
T4945 | 11329-11332 | CC | denotes | but |
T4944 | 11327-11328 | -COMMA- | denotes | , |
T4943 | 11313-11327 | NN | denotes | ubiquitination |
T4942 | 11308-11312 | NN | denotes | RIP1 |
T4941 | 11304-11307 | IN | denotes | for |
T4940 | 11293-11303 | NN | denotes | candidates |
T4939 | 11288-11292 | JJ | denotes | good |
T4938 | 11284-11287 | VB | denotes | are |
T4937 | 11276-11283 | NN | denotes | cIAP1/2 |
T4936 | 11272-11275 | CC | denotes | and |
T4935 | 11264-11271 | NN | denotes | TRAF2/5 |
T4934 | 11256-11262 | NN | denotes | chains |
T4933 | 11242-11255 | NN | denotes | polyubiquitin |
T4932 | 11231-11241 | JJ | denotes | K63-linked |
T4931 | 11228-11230 | IN | denotes | by |
T4930 | 11219-11227 | VB | denotes | modified |
T4929 | 11211-11218 | RB | denotes | rapidly |
T4928 | 11208-11210 | VB | denotes | is |
T4927 | 11203-11207 | NN | denotes | RIP1 |
T4926 | 11197-11202 | VB | denotes | bound |
T4925 | 11184-11196 | NN | denotes | TNF-receptor |
T4924 | 11182-11183 | -COMMA- | denotes | , |
T4923 | 11171-11182 | NN | denotes | stimulation |
T4922 | 11167-11170 | NN | denotes | TNF |
T4921 | 11164-11166 | IN | denotes | On |
T4920 | 11161-11162 | -RRB- | denotes | ) |
T4919 | 11160-11161 | CD | denotes | 1 |
T4918 | 11153-11159 | NN | denotes | Figure |
T4917 | 11152-11153 | -LRB- | denotes | ( |
T4916 | 11146-11151 | NN | denotes | cIAP2 |
T4915 | 11142-11145 | CC | denotes | and |
T4914 | 11140-11141 | CD | denotes | 1 |
T4913 | 11138-11139 | -RRB- | denotes | ) |
T4912 | 11134-11138 | NN | denotes | cIAP |
T4911 | 11133-11134 | -LRB- | denotes | ( |
T4910 | 11123-11132 | NN | denotes | apoptosis |
T4909 | 11120-11122 | IN | denotes | of |
T4908 | 11110-11119 | NN | denotes | inhibitor |
T4907 | 11101-11109 | JJ | denotes | cellular |
T4906 | 11093-11100 | NN | denotes | ligases |
T4905 | 11083-11092 | NN | denotes | ubiquitin |
T4904 | 11080-11082 | NN | denotes | E3 |
T4903 | 11076-11079 | DT | denotes | the |
T4902 | 11071-11075 | VB | denotes | bind |
T4901 | 11066-11070 | NN | denotes | turn |
T4900 | 11063-11065 | IN | denotes | in |
T4899 | 11057-11062 | WDT | denotes | which |
T4898 | 11055-11056 | -COMMA- | denotes | , |
T4897 | 11050-11055 | NN | denotes | TRAF5 |
T4896 | 11046-11049 | CC | denotes | and |
T4895 | 11044-11045 | CD | denotes | 2 |
T4894 | 11042-11043 | -RRB- | denotes | ) |
T4893 | 11038-11042 | NN | denotes | TRAF |
T4892 | 11037-11038 | -LRB- | denotes | ( |
T4891 | 11030-11036 | NN | denotes | factor |
T4890 | 11010-11029 | JJ | denotes | receptor-associated |
T4889 | 11006-11009 | NN | denotes | TNF |
T4888 | 10998-11005 | NN | denotes | ligases |
T4887 | 10988-10997 | NN | denotes | ubiquitin |
T4886 | 10985-10987 | NN | denotes | E3 |
T4885 | 10981-10984 | DT | denotes | the |
T4884 | 10977-10980 | IN | denotes | for |
T4883 | 10968-10976 | NN | denotes | proteins |
T4882 | 10960-10967 | NN | denotes | adaptor |
T4881 | 10957-10959 | IN | denotes | as |
T4880 | 10948-10956 | VB | denotes | function |
T4879 | 10942-10947 | WDT | denotes | which |
T4878 | 10940-10941 | -COMMA- | denotes | , |
T4877 | 10939-10940 | -RRB- | denotes | ) |
T4876 | 10935-10939 | NN | denotes | RIP1 |
T4875 | 10934-10935 | -LRB- | denotes | ( |
T4874 | 10932-10933 | CD | denotes | 1 |
T4873 | 10924-10931 | NN | denotes | protein |
T4872 | 10912-10923 | VB | denotes | interacting |
T4871 | 10903-10911 | NN | denotes | receptor |
T4870 | 10900-10902 | IN | denotes | of |
T4869 | 10896-10899 | CC | denotes | and |
T4868 | 10888-10895 | NN | denotes | protein |
T4867 | 10886-10887 | -RRB- | denotes | ) |
T4866 | 10881-10886 | NN | denotes | TRADD |
T4865 | 10880-10881 | -LRB- | denotes | ( |
T4864 | 10873-10879 | NN | denotes | domain |
T4863 | 10867-10872 | NN | denotes | death |
T4862 | 10845-10866 | JJ | denotes | receptor-1-associated |
T4861 | 10841-10844 | NN | denotes | TNF |
T4860 | 10838-10840 | IN | denotes | of |
T4859 | 10826-10837 | NN | denotes | recruitment |
T4858 | 10822-10825 | DT | denotes | the |
T4857 | 10819-10821 | IN | denotes | in |
T4856 | 10811-10818 | VB | denotes | results |
T4855 | 10799-10810 | NN | denotes | stimulation |
T4854 | 10795-10798 | NN | denotes | TNF |
T5488 | 15912-15913 | -RRB- | denotes | ] |
T5487 | 15907-15912 | CD | denotes | 30,31 |
T5486 | 15906-15907 | -LRB- | denotes | [ |
T5485 | 15895-15905 | NN | denotes | signalling |
T5484 | 15890-15894 | NN | denotes | CD40 |
T5483 | 15887-15889 | IN | denotes | of |
T5482 | 15877-15886 | NN | denotes | regulator |
T5481 | 15868-15876 | JJ | denotes | negative |
T5480 | 15866-15867 | DT | denotes | a |
T5479 | 15863-15865 | IN | denotes | as |
T5478 | 15856-15862 | VB | denotes | serves |
T5477 | 15850-15855 | NN | denotes | TRAF3 |
T5476 | 15846-15849 | CC | denotes | and |
T5475 | 15844-15845 | -COMMA- | denotes | , |
T5474 | 15839-15844 | NN | denotes | NF-κB |
T5473 | 15836-15838 | IN | denotes | of |
T5472 | 15825-15835 | NN | denotes | activation |
T5471 | 15821-15824 | IN | denotes | for |
T5470 | 15812-15820 | VB | denotes | required |
T5469 | 15809-15811 | VB | denotes | is |
T5468 | 15803-15808 | NN | denotes | TRAF2 |
T5467 | 15797-15802 | IN | denotes | while |
T5466 | 15795-15796 | -COMMA- | denotes | , |
T5465 | 15785-15795 | NN | denotes | production |
T5464 | 15780-15784 | NN | denotes | IL-6 |
T5463 | 15776-15779 | CC | denotes | and |
T5462 | 15765-15775 | NN | denotes | activation |
T5461 | 15761-15764 | NN | denotes | JNK |
T5460 | 15747-15760 | JJ | denotes | CD40-mediated |
T5459 | 15743-15746 | IN | denotes | for |
T5458 | 15734-15742 | VB | denotes | required |
T5457 | 15731-15733 | VB | denotes | is |
T5456 | 15725-15730 | NN | denotes | TRAF6 |
T5455 | 15719-15724 | NN | denotes | cells |
T5454 | 15717-15718 | NN | denotes | B |
T5453 | 15714-15716 | IN | denotes | in |
T5452 | 15712-15713 | -COMMA- | denotes | , |
T5451 | 15705-15712 | NN | denotes | example |
T5450 | 15701-15704 | IN | denotes | For |
T5449 | 15690-15699 | NN | denotes | functions |
T5448 | 15676-15689 | JJ | denotes | CD40-mediated |
T5447 | 15667-15675 | JJ | denotes | distinct |
T5446 | 15663-15666 | CC | denotes | and |
T5445 | 15651-15662 | VB | denotes | overlapping |
T5444 | 15646-15650 | IN | denotes | with |
T5443 | 15635-15645 | VB | denotes | associated |
T5442 | 15631-15634 | VB | denotes | are |
T5441 | 15621-15630 | NN | denotes | molecules |
T5440 | 15616-15620 | NN | denotes | TRAF |
T5439 | 15607-15615 | JJ | denotes | Specific |
T5438 | 15600-15605 | RB | denotes | above |
T5437 | 15590-15599 | VB | denotes | described |
T5436 | 15587-15589 | IN | denotes | as |
T5435 | 15579-15586 | NN | denotes | pathway |
T5434 | 15566-15578 | JJ | denotes | noncanonical |
T5433 | 15562-15565 | DT | denotes | the |
T5432 | 15559-15561 | IN | denotes | of |
T5431 | 15548-15558 | NN | denotes | activation |
T5430 | 15544-15547 | DT | denotes | the |
T5429 | 15541-15543 | IN | denotes | in |
T5428 | 15536-15540 | NN | denotes | step |
T5427 | 15526-15535 | JJ | denotes | important |
T5426 | 15523-15525 | DT | denotes | an |
T5425 | 15512-15522 | VB | denotes | represents |
T5424 | 15506-15511 | WDT | denotes | which |
T5423 | 15504-15505 | -COMMA- | denotes | , |
T5422 | 15499-15504 | NN | denotes | TRAF3 |
T5421 | 15495-15498 | CC | denotes | and |
T5420 | 15489-15494 | NN | denotes | TRAF2 |
T5419 | 15484-15488 | CC | denotes | both |
T5418 | 15481-15483 | IN | denotes | of |
T5417 | 15469-15480 | NN | denotes | proteolysis |
T5416 | 15465-15468 | DT | denotes | the |
T5415 | 15462-15464 | TO | denotes | to |
T4853 | 10786-10793 | NN | denotes | pathway |
T4852 | 10782-10785 | NN | denotes | TNF |
T4851 | 10778-10781 | DT | denotes | the |
T4850 | 10775-10777 | VB | denotes | is |
T4849 | 10766-10774 | NN | denotes | pathways |
T4848 | 10755-10765 | NN | denotes | signalling |
T4847 | 10749-10754 | NN | denotes | NF-κB |
T4846 | 10741-10748 | VB | denotes | studied |
T4845 | 10736-10740 | JJ | denotes | best |
T4844 | 10732-10735 | DT | denotes | the |
T4843 | 10729-10731 | IN | denotes | of |
T4842 | 10725-10728 | CD | denotes | One |
T4841 | 8527-8528 | -RRB- | denotes | ] |
T4840 | 8525-8527 | CD | denotes | 21 |
T4839 | 8524-8525 | -LRB- | denotes | [ |
T4838 | 8513-8523 | NN | denotes | activation |
T4837 | 8507-8512 | NN | denotes | NF-κB |
T4836 | 8497-8506 | JJ | denotes | canonical |
T4835 | 8493-8496 | IN | denotes | for |
T4834 | 8484-8492 | VB | denotes | required |
T4833 | 8480-8483 | VB | denotes | are |
T4832 | 8478-8479 | -COMMA- | denotes | , |
T4831 | 8474-8478 | NN | denotes | IKK1 |
T4830 | 8470-8473 | RB | denotes | not |
T4829 | 8466-8469 | CC | denotes | but |
T4828 | 8464-8465 | -COMMA- | denotes | , |
T4827 | 8460-8464 | NN | denotes | NEMO |
T4826 | 8456-8459 | CC | denotes | and |
T4825 | 8451-8455 | NN | denotes | IKK2 |
T4824 | 8446-8450 | IN | denotes | that |
T4823 | 8439-8445 | VB | denotes | showed |
T4822 | 8427-8438 | NN | denotes | experiments |
T4821 | 8417-8426 | VB | denotes | targeting |
T4820 | 8412-8416 | NN | denotes | Gene |
T4819 | 8409-8410 | -RRB- | denotes | ) |
T4818 | 8408-8409 | CD | denotes | 1 |
T4817 | 8401-8407 | NN | denotes | Figure |
T4816 | 8400-8401 | -LRB- | denotes | ( |
T4815 | 8398-8399 | -RRB- | denotes | ) |
T4814 | 8394-8398 | NN | denotes | IKKγ |
T4813 | 8391-8393 | IN | denotes | as |
T4812 | 8385-8390 | VB | denotes | known |
T4811 | 8380-8384 | RB | denotes | also |
T4810 | 8378-8379 | -COLON- | denotes | - |
T4809 | 8373-8377 | NN | denotes | NEMO |
T4808 | 8372-8373 | -LRB- | denotes | ( |
T4807 | 8362-8371 | NN | denotes | modulator |
T4806 | 8352-8361 | JJ | denotes | essential |
T4805 | 8346-8351 | NN | denotes | NF-κB |
T4804 | 8338-8345 | NN | denotes | subunit |
T4803 | 8327-8337 | JJ | denotes | regulatory |
T4802 | 8323-8326 | DT | denotes | the |
T4801 | 8319-8322 | CC | denotes | and |
T4800 | 8317-8318 | -RRB- | denotes | ) |
T4799 | 8313-8317 | NN | denotes | IKKβ |
T4798 | 8309-8312 | CC | denotes | and |
T4797 | 8304-8308 | NN | denotes | IKKα |
T4796 | 8301-8303 | IN | denotes | as |
T4795 | 8295-8300 | VB | denotes | known |
T4794 | 8290-8294 | RB | denotes | also |
T4793 | 8289-8290 | -LRB- | denotes | ( |
T4792 | 8284-8288 | NN | denotes | IKK2 |
T4791 | 8280-8283 | CC | denotes | and |
T4790 | 8275-8279 | NN | denotes | IKK1 |
T4789 | 8266-8274 | NN | denotes | subunits |
T4788 | 8256-8265 | JJ | denotes | catalytic |
T4787 | 8252-8255 | CD | denotes | two |
T4786 | 8248-8251 | DT | denotes | the |
T4785 | 8245-8247 | IN | denotes | of |
T4784 | 8235-8244 | VB | denotes | comprised |
T4783 | 8232-8234 | VB | denotes | is |
T4782 | 8224-8231 | NN | denotes | complex |
T4781 | 8220-8223 | NN | denotes | IKK |
T4780 | 8216-8219 | DT | denotes | The |
T4779 | 8213-8214 | -RRB- | denotes | ] |
T4778 | 8211-8213 | CD | denotes | 20 |
T4777 | 8210-8211 | -LRB- | denotes | [ |
T4776 | 8199-8209 | NN | denotes | proteasome |
T4775 | 8195-8198 | DT | denotes | the |
T4774 | 8192-8194 | IN | denotes | by |
T4773 | 8180-8191 | NN | denotes | degradation |
T4772 | 8176-8179 | CC | denotes | and |
T4771 | 8153-8175 | NN | denotes | K48-polyubiquitination |
T4770 | 8149-8152 | PRP-DOLLAR- | denotes | its |
T4769 | 8146-8148 | TO | denotes | to |
T4768 | 8138-8145 | VB | denotes | leading |
T4767 | 8130-8137 | NN | denotes | protein |
T4766 | 8126-8129 | NN | denotes | IκB |
T4765 | 8115-8125 | JJ | denotes | inhibitory |
T4764 | 8111-8114 | DT | denotes | the |
T4763 | 8108-8110 | IN | denotes | of |
T4762 | 8092-8107 | NN | denotes | phosphorylation |
T4761 | 8083-8091 | VB | denotes | mediates |
T4760 | 8077-8082 | WDT | denotes | which |
T4759 | 8075-8076 | -COMMA- | denotes | , |
T4758 | 8068-8075 | NN | denotes | complex |
T4757 | 8066-8067 | -RRB- | denotes | ) |
T4756 | 8063-8066 | NN | denotes | IKK |
T4755 | 8062-8063 | -LRB- | denotes | ( |
T4754 | 8055-8061 | NN | denotes | kinase |
T4753 | 8051-8054 | NN | denotes | IκB |
T4752 | 8047-8050 | DT | denotes | the |
T4751 | 8044-8046 | IN | denotes | of |
T4750 | 8033-8043 | NN | denotes | activation |
T4749 | 8029-8032 | DT | denotes | the |
T4748 | 8026-8028 | IN | denotes | in |
T4747 | 8017-8025 | VB | denotes | converge |
T4746 | 8006-8016 | RB | denotes | ultimately |
T4745 | 8002-8005 | CC | denotes | but |
T4744 | 8000-8001 | -COMMA- | denotes | , |
T4743 | 7992-8000 | JJ | denotes | specific |
T4742 | 7983-7991 | NN | denotes | receptor |
T4741 | 7977-7982 | RB | denotes | often |
T4740 | 7973-7976 | VB | denotes | are |
T4739 | 7968-7972 | WDT | denotes | that |
T4738 | 7955-7967 | NN | denotes | interactions |
T4655 | 7455-7465 | NN | denotes | precursors |
T4654 | 7451-7454 | VB | denotes | are |
T4653 | 7446-7450 | NN | denotes | p105 |
T4652 | 7442-7445 | CC | denotes | and |
T4651 | 7437-7441 | NN | denotes | p100 |
T4650 | 7428-7436 | NN | denotes | nucleus. |
T4649 | 7424-7427 | DT | denotes | the |
T4648 | 7421-7423 | IN | denotes | in |
T4647 | 7405-7420 | NN | denotes | transactivation |
T4646 | 7399-7404 | NN | denotes | NF-κB |
T4645 | 7388-7398 | VB | denotes | potentiate |
T4644 | 7380-7387 | RB | denotes | instead |
T4643 | 7374-7379 | NN | denotes | Bcl-3 |
T4642 | 7370-7373 | CC | denotes | and |
T4641 | 7365-7369 | NN | denotes | IκBξ |
T4640 | 7363-7364 | -COMMA- | denotes | , |
T4639 | 7358-7363 | NN | denotes | NF-κB |
T4638 | 7355-7357 | IN | denotes | of |
T4637 | 7344-7354 | NN | denotes | inhibitors |
T4636 | 7341-7343 | IN | denotes | as |
T4635 | 7335-7340 | VB | denotes | serve |
T4634 | 7333-7334 | -RRB- | denotes | ) |
T4633 | 7332-7333 | -RRB- | denotes | ) |
T4632 | 7326-7332 | NN | denotes | NF-κB2 |
T4631 | 7323-7325 | IN | denotes | as |
T4630 | 7317-7322 | VB | denotes | known |
T4629 | 7312-7316 | RB | denotes | also |
T4628 | 7311-7312 | -LRB- | denotes | ( |
T4627 | 7306-7310 | NN | denotes | p100 |
T4626 | 7304-7305 | -COMMA- | denotes | , |
T4625 | 7303-7304 | -RRB- | denotes | ) |
T4624 | 7297-7303 | NN | denotes | NF-κB1 |
T4623 | 7294-7296 | IN | denotes | as |
T4622 | 7288-7293 | VB | denotes | known |
T4621 | 7283-7287 | RB | denotes | also |
T4620 | 7282-7283 | -LRB- | denotes | ( |
T4619 | 7277-7281 | NN | denotes | p105 |
T4618 | 7275-7276 | -COMMA- | denotes | , |
T4617 | 7271-7275 | NN | denotes | IκBε |
T4616 | 7269-7270 | -COMMA- | denotes | , |
T4615 | 7265-7269 | NN | denotes | IκBβ |
T4614 | 7263-7264 | -COMMA- | denotes | , |
T4613 | 7259-7263 | NN | denotes | IκBα |
T4612 | 7258-7259 | -LRB- | denotes | ( |
T4611 | 7253-7257 | NN | denotes | IκBs |
T4610 | 7250-7252 | IN | denotes | of |
T4609 | 7241-7249 | NN | denotes | majority |
T4608 | 7237-7240 | DT | denotes | the |
T4607 | 7229-7236 | IN | denotes | Whereas |
T4606 | 7226-7227 | -RRB- | denotes | ] |
T4605 | 7224-7226 | CD | denotes | 19 |
T4604 | 7223-7224 | -LRB- | denotes | [ |
T4603 | 7215-7222 | NN | denotes | binding |
T4602 | 7211-7214 | NN | denotes | DNA |
T4601 | 7207-7210 | CC | denotes | and |
T4600 | 7193-7206 | NN | denotes | translocation |
T4599 | 7185-7192 | JJ | denotes | nuclear |
T4598 | 7179-7184 | NN | denotes | NF-κB |
T4597 | 7171-7178 | VB | denotes | prevent |
T4596 | 7165-7170 | WDT | denotes | which |
T4595 | 7163-7164 | -COMMA- | denotes | , |
T4594 | 7155-7163 | NN | denotes | proteins |
T4593 | 7153-7154 | -RRB- | denotes | ) |
T4592 | 7150-7153 | NN | denotes | IκB |
T4591 | 7149-7150 | -LRB- | denotes | ( |
T4590 | 7143-7148 | NN | denotes | NF-κB |
T4589 | 7140-7142 | IN | denotes | of |
T4588 | 7130-7139 | NN | denotes | inhibitor |
T4587 | 7127-7129 | IN | denotes | as |
T4586 | 7124-7126 | TO | denotes | to |
T4585 | 7115-7123 | VB | denotes | referred |
T4584 | 7106-7114 | NN | denotes | proteins |
T4583 | 7095-7105 | JJ | denotes | inhibitory |
T4582 | 7092-7094 | IN | denotes | by |
T4581 | 7082-7091 | NN | denotes | complexes |
T4580 | 7075-7081 | JJ | denotes | latent |
T4579 | 7072-7074 | IN | denotes | as |
T4578 | 7062-7071 | NN | denotes | cytoplasm |
T4577 | 7058-7061 | DT | denotes | the |
T4576 | 7055-7057 | IN | denotes | in |
T4575 | 7043-7054 | VB | denotes | sequestered |
T4574 | 7039-7042 | VB | denotes | are |
T4573 | 7030-7038 | NN | denotes | proteins |
T4572 | 7024-7029 | NN | denotes | NF-κB |
T5143 | 12549-12555 | JJ | denotes | direct |
T5142 | 12547-12548 | DT | denotes | a |
T5141 | 12543-12546 | IN | denotes | via |
T5140 | 12541-12542 | -RRB- | denotes | ] |
T5139 | 12539-12541 | CD | denotes | 26 |
T5138 | 12538-12539 | -LRB- | denotes | [ |
T5137 | 12533-12537 | NN | denotes | RIP1 |
T5136 | 12529-12532 | CC | denotes | and |
T5135 | 12527-12528 | -RRB- | denotes | ] |
T5134 | 12525-12527 | CD | denotes | 25 |
T5133 | 12524-12525 | -LRB- | denotes | [ |
T5132 | 12518-12523 | NN | denotes | TRAF6 |
T5131 | 12509-12517 | VB | denotes | recruits |
T5130 | 12504-12508 | RB | denotes | also |
T5129 | 12499-12503 | NN | denotes | TRIF |
T5128 | 12496-12497 | -RRB- | denotes | ] |
T5127 | 12494-12496 | CD | denotes | 24 |
T5126 | 12493-12494 | -LRB- | denotes | [ |
T5125 | 12487-12492 | NN | denotes | TRAF6 |
T5124 | 12484-12486 | IN | denotes | of |
T5123 | 12465-12483 | NN | denotes | selfubiquitination |
T5122 | 12461-12464 | CC | denotes | and |
T5121 | 12445-12460 | NN | denotes | oligomerisation |
T5120 | 12442-12444 | TO | denotes | to |
T5119 | 12434-12441 | VB | denotes | leading |
T5118 | 12432-12433 | -COMMA- | denotes | , |
T5117 | 12427-12432 | NN | denotes | TRAF6 |
T5116 | 12423-12426 | CC | denotes | and |
T5115 | 12416-12422 | NN | denotes | family |
T5114 | 12414-12415 | -RRB- | denotes | ) |
T5113 | 12410-12414 | NN | denotes | IRAK |
T5112 | 12409-12410 | -LRB- | denotes | ( |
T5111 | 12402-12408 | NN | denotes | kinase |
T5110 | 12385-12401 | JJ | denotes | IL-1R-associated |
T5109 | 12381-12384 | DT | denotes | the |
T5108 | 12378-12380 | IN | denotes | of |
T5107 | 12370-12377 | NN | denotes | members |
T5106 | 12361-12369 | VB | denotes | recruits |
T5105 | 12356-12360 | NN | denotes | turn |
T5104 | 12353-12355 | IN | denotes | in |
T5103 | 12347-12352 | NN | denotes | MyD88 |
T5102 | 12333-12345 | RB | denotes | respectively |
T5101 | 12331-12332 | -COMMA- | denotes | , |
T5100 | 12330-12331 | -RRB- | denotes | ) |
T5099 | 12326-12330 | NN | denotes | TRIF |
T5098 | 12325-12326 | -LRB- | denotes | ( |
T5097 | 12320-12324 | NN | denotes | IFNβ |
T5096 | 12303-12319 | JJ | denotes | adaptor-inducing |
T5095 | 12285-12302 | JJ | denotes | domain-containing |
T5094 | 12281-12284 | NN | denotes | TIR |
T5093 | 12277-12280 | CC | denotes | and |
T5092 | 12275-12276 | -RRB- | denotes | ) |
T5091 | 12270-12275 | NN | denotes | MyD88 |
T5090 | 12269-12270 | -LRB- | denotes | ( |
T5089 | 12266-12268 | CD | denotes | 88 |
T5088 | 12261-12265 | NN | denotes | gene |
T5087 | 12252-12260 | NN | denotes | response |
T5086 | 12244-12251 | JJ | denotes | primary |
T5085 | 12228-12243 | NN | denotes | differentiation |
T5084 | 12220-12227 | JJ | denotes | myeloid |
T5083 | 12212-12219 | VB | denotes | recruit |
T5082 | 12209-12211 | TO | denotes | to |
T5081 | 12201-12208 | NN | denotes | factors |
T5080 | 12192-12200 | VB | denotes | bridging |
T5079 | 12189-12191 | IN | denotes | as |
T5078 | 12183-12188 | VB | denotes | serve |
T5077 | 12174-12182 | RB | denotes | probably |
T5076 | 12169-12173 | RB | denotes | most |
T5075 | 12163-12168 | WDT | denotes | which |
T5074 | 12161-12162 | -COMMA- | denotes | , |
T5073 | 12160-12161 | -RRB- | denotes | ) |
T5072 | 12156-12160 | NN | denotes | TRAM |
T5071 | 12155-12156 | -LRB- | denotes | ( |
T5070 | 12146-12154 | NN | denotes | molecule |
T5069 | 12138-12145 | NN | denotes | adaptor |
T5068 | 12125-12137 | JJ | denotes | TRIF-related |
T5067 | 12121-12124 | CC | denotes | and |
T5066 | 12119-12120 | -RRB- | denotes | ) |
T5065 | 12116-12119 | NNP | denotes | Mal |
T5064 | 12113-12115 | IN | denotes | as |
T5063 | 12110-12112 | TO | denotes | to |
T5062 | 12101-12109 | VB | denotes | referred |
T5061 | 12096-12100 | RB | denotes | also |
T5060 | 12095-12096 | -LRB- | denotes | ( |
T5059 | 12087-12094 | NN | denotes | protein |
T5058 | 12079-12086 | NN | denotes | adaptor |
T5057 | 12070-12078 | NN | denotes | receptor |
T5056 | 12060-12069 | NN | denotes | Toll/IL-1 |
T5055 | 12057-12059 | IN | denotes | of |
T5054 | 12045-12056 | NN | denotes | recruitment |
T5053 | 12041-12044 | DT | denotes | the |
T5052 | 12033-12040 | VB | denotes | induces |
T5051 | 12014-12032 | NN | denotes | lipopolysaccharide |
T5050 | 12011-12013 | IN | denotes | by |
T5049 | 11999-12010 | NN | denotes | stimulation |
T5048 | 11994-11998 | NN | denotes | TLR4 |
T5047 | 11992-11993 | -COMMA- | denotes | , |
T5046 | 11985-11992 | NN | denotes | example |
T5045 | 11981-11984 | IN | denotes | For |
T5044 | 11970-11979 | NN | denotes | receptors |
T5043 | 11964-11969 | JJ | denotes | other |
T5042 | 11961-11963 | TO | denotes | to |
T5041 | 11955-11960 | VB | denotes | apply |
T5040 | 11944-11954 | NN | denotes | principles |
T5039 | 11933-11943 | NN | denotes | signalling |
T5038 | 11925-11932 | JJ | denotes | Similar |
T5037 | 11922-11923 | -RRB- | denotes | ] |
T5036 | 11920-11922 | CD | denotes | 23 |
T5035 | 11919-11920 | -LRB- | denotes | [ |
T5034 | 11911-11918 | NN | denotes | complex |
T5033 | 11906-11910 | NN | denotes | TAK1 |
T5032 | 11902-11905 | DT | denotes | the |
T5031 | 11893-11901 | VB | denotes | activate |
T5030 | 11884-11892 | RB | denotes | directly |
T5029 | 11880-11883 | MD | denotes | can |
T5028 | 11873-11879 | NN | denotes | chains |
T5027 | 11859-11872 | NN | denotes | polyubiquitin |
T5026 | 11848-11858 | JJ | denotes | unanchored |
T5025 | 11843-11847 | IN | denotes | that |
T5024 | 11833-11842 | VB | denotes | suggested |
T5023 | 11824-11832 | RB | denotes | recently |
T5022 | 11820-11823 | VB | denotes | was |
T5021 | 11817-11819 | PRP | denotes | it |
T5020 | 11814-11816 | IN | denotes | as |
T5019 | 11812-11813 | -COMMA- | denotes | , |
T5018 | 11805-11812 | JJ | denotes | unclear |
T5017 | 11797-11804 | VB | denotes | remains |
T5016 | 11790-11796 | NN | denotes | chains |
T5015 | 11776-11789 | NN | denotes | polyubiquitin |
T5014 | 11759-11775 | JJ | denotes | protein-anchored |
T5013 | 11756-11758 | IN | denotes | of |
T5012 | 11751-11755 | NN | denotes | role |
T5011 | 11745-11750 | JJ | denotes | exact |
T5010 | 11741-11744 | DT | denotes | The |
T5009 | 11738-11739 | -RRB- | denotes | ] |
T5008 | 11736-11738 | CD | denotes | 22 |
T5007 | 11735-11736 | -LRB- | denotes | [ |
T5006 | 11724-11734 | NN | denotes | complexity |
T5005 | 11716-11723 | JJ | denotes | further |
T5004 | 11711-11715 | VB | denotes | adds |
T5003 | 11700-11710 | NN | denotes | signalling |
T5002 | 11694-11699 | NN | denotes | NF-κB |
T5001 | 11680-11693 | JJ | denotes | TNF-activated |
T5000 | 11676-11679 | IN | denotes | for |
T4999 | 11666-11675 | JJ | denotes | essential |
T4998 | 11663-11665 | VB | denotes | is |
T4997 | 11659-11662 | CC | denotes | and |
T4996 | 11652-11658 | NN | denotes | chains |
T4995 | 11638-11651 | NN | denotes | polyubiquitin |
T4994 | 11631-11637 | JJ | denotes | linear |
T4993 | 11626-11630 | IN | denotes | with |
T4992 | 11621-11625 | NN | denotes | NEMO |
T4991 | 11612-11620 | VB | denotes | modifies |
T4990 | 11607-11611 | WDT | denotes | that |
T4989 | 11599-11606 | NN | denotes | complex |
T4988 | 11592-11598 | NN | denotes | enzyme |
T4987 | 11586-11591 | NN | denotes | E2/E3 |
T4986 | 11577-11585 | JJ | denotes | distinct |
T4985 | 11575-11576 | DT | denotes | a |
T4984 | 11572-11574 | IN | denotes | of |
T4983 | 11557-11571 | NN | denotes | identification |
T4982 | 11550-11556 | JJ | denotes | recent |
T4981 | 11546-11549 | DT | denotes | The |
T4980 | 11532-11544 | RB | denotes | respectively |
T4979 | 11530-11531 | -COMMA- | denotes | , |
T4978 | 11524-11530 | NN | denotes | TAB1/2 |
T4977 | 11520-11523 | CC | denotes | and |
T4976 | 11515-11519 | NN | denotes | NEMO |
T4975 | 11506-11514 | NN | denotes | proteins |
T4974 | 11488-11505 | JJ | denotes | ubiquitin-binding |
T4973 | 11484-11487 | DT | denotes | the |
T4972 | 11480-11483 | IN | denotes | via |
T4971 | 11472-11479 | NN | denotes | complex |
T4970 | 11467-11471 | NN | denotes | TAK1 |
T4969 | 11463-11466 | CC | denotes | and |
T4968 | 11459-11462 | NN | denotes | IKK |
T4967 | 11455-11458 | DT | denotes | the |
T4966 | 11447-11454 | VB | denotes | recruit |
T4965 | 11444-11446 | TO | denotes | to |
T4964 | 11435-11443 | NN | denotes | scaffold |
T4963 | 11433-11434 | DT | denotes | a |
T4962 | 11426-11432 | VB | denotes | create |
T4961 | 11423-11425 | TO | denotes | to |
T4960 | 11414-11422 | VB | denotes | believed |
T4959 | 11410-11413 | VB | denotes | are |
T4958 | 11405-11409 | NN | denotes | RIP1 |
T4957 | 11402-11404 | IN | denotes | on |
T4956 | 11395-11401 | NN | denotes | chains |
T4955 | 11381-11394 | NN | denotes | polyubiquitin |
T4954 | 11377-11380 | DT | denotes | The |
T5198 | 12849-12859 | NN | denotes | proteasome |
T5197 | 12845-12848 | DT | denotes | the |
T5196 | 12842-12844 | IN | denotes | by |
T5195 | 12832-12841 | VB | denotes | processed |
T5194 | 12829-12831 | VB | denotes | is |
T5193 | 12824-12828 | NN | denotes | p100 |
T5192 | 12822-12823 | -COMMA- | denotes | , |
T5191 | 12815-12822 | NN | denotes | pathway |
T5190 | 12810-12814 | DT | denotes | this |
T5189 | 12807-12809 | IN | denotes | In |
T5188 | 12804-12805 | -RRB- | denotes | ) |
T5187 | 12803-12804 | CD | denotes | 2 |
T5186 | 12796-12802 | NN | denotes | Figure |
T5185 | 12795-12796 | -LRB- | denotes | ( |
T5184 | 12790-12794 | NN | denotes | RANK |
T5183 | 12786-12789 | CC | denotes | and |
T5182 | 12784-12785 | -COMMA- | denotes | , |
T5181 | 12780-12784 | NN | denotes | CD40 |
T5180 | 12778-12779 | -COMMA- | denotes | , |
T5179 | 12770-12778 | NN | denotes | receptor |
T5178 | 12765-12769 | NN | denotes | BAFF |
T5177 | 12763-12764 | -COMMA- | denotes | , |
T5176 | 12755-12763 | NN | denotes | receptor |
T5175 | 12753-12754 | NN | denotes | β |
T5174 | 12741-12752 | NN | denotes | lymphotoxin |
T5173 | 12737-12740 | DT | denotes | the |
T5172 | 12734-12736 | IN | denotes | by |
T5171 | 12724-12733 | VB | denotes | activated |
T5170 | 12721-12723 | VB | denotes | be |
T5169 | 12717-12720 | MD | denotes | can |
T5168 | 12709-12716 | NN | denotes | pathway |
T5167 | 12703-12708 | NN | denotes | NF-κB |
T5166 | 12690-12702 | JJ | denotes | noncanonical |
T5165 | 12686-12689 | DT | denotes | The |
T5164 | 12683-12684 | -RRB- | denotes | ) |
T5163 | 12682-12683 | CD | denotes | 1 |
T5162 | 12675-12681 | NN | denotes | Figure |
T5161 | 12674-12675 | -LRB- | denotes | ( |
T5160 | 12666-12673 | NN | denotes | pathway |
T5159 | 12662-12665 | NN | denotes | TNF |
T5158 | 12658-12661 | DT | denotes | the |
T5157 | 12655-12657 | TO | denotes | to |
T5156 | 12647-12654 | JJ | denotes | similar |
T5155 | 12640-12646 | NN | denotes | manner |
T5154 | 12615-12639 | JJ | denotes | ubiquitination-dependent |
T5153 | 12613-12614 | DT | denotes | a |
T5152 | 12610-12612 | IN | denotes | in |
T5151 | 12606-12609 | NN | denotes | IKK |
T5150 | 12602-12605 | CC | denotes | and |
T5149 | 12597-12601 | NN | denotes | TAK1 |
T5148 | 12588-12596 | VB | denotes | activate |
T5147 | 12583-12587 | RB | denotes | then |
T5146 | 12574-12582 | NN | denotes | pathways |
T5145 | 12569-12573 | DT | denotes | Both |
T5144 | 12556-12567 | NN | denotes | interaction |
T4737 | 7939-7954 | JJ | denotes | protein-protein |
T4736 | 7930-7938 | JJ | denotes | proximal |
T4735 | 7927-7929 | IN | denotes | of |
T4734 | 7917-7926 | NN | denotes | formation |
T4733 | 7913-7916 | DT | denotes | the |
T4732 | 7904-7912 | VB | denotes | requires |
T4731 | 7894-7903 | NN | denotes | receptors |
T4730 | 7884-7893 | JJ | denotes | different |
T4729 | 7881-7883 | IN | denotes | by |
T4728 | 7871-7880 | VB | denotes | initiated |
T4727 | 7860-7870 | NN | denotes | signalling |
T4726 | 7854-7859 | NN | denotes | NF-κB |
T4725 | 7845-7852 | NN | denotes | ligands |
T4724 | 7841-7844 | NN | denotes | TLR |
T4723 | 7837-7840 | CC | denotes | and |
T4722 | 7835-7836 | -COMMA- | denotes | , |
T4721 | 7830-7835 | NN | denotes | RANKL |
T4720 | 7828-7829 | -COMMA- | denotes | , |
T4719 | 7820-7828 | NN | denotes | antigens |
T4718 | 7818-7819 | -COMMA- | denotes | , |
T4717 | 7817-7818 | -RRB- | denotes | ) |
T4716 | 7813-7817 | NN | denotes | IL-1 |
T4715 | 7811-7812 | -COMMA- | denotes | , |
T4714 | 7808-7811 | NN | denotes | TNF |
T4713 | 7806-7807 | -COMMA- | denotes | , |
T4712 | 7799-7806 | NN | denotes | example |
T4711 | 7795-7798 | IN | denotes | for |
T4710 | 7794-7795 | -LRB- | denotes | ( |
T4709 | 7784-7793 | NN | denotes | cytokines |
T4708 | 7768-7783 | JJ | denotes | proinflammatory |
T4707 | 7758-7767 | VB | denotes | including |
T4706 | 7750-7757 | NN | denotes | stimuli |
T4705 | 7745-7749 | JJ | denotes | many |
T4704 | 7742-7744 | IN | denotes | by |
T4703 | 7732-7741 | VB | denotes | triggered |
T4702 | 7729-7731 | VB | denotes | is |
T4701 | 7725-7728 | CC | denotes | and |
T4700 | 7723-7724 | -COMMA- | denotes | , |
T4699 | 7715-7723 | NN | denotes | immunity |
T4698 | 7706-7714 | JJ | denotes | adaptive |
T4697 | 7702-7705 | CC | denotes | and |
T4696 | 7695-7701 | JJ | denotes | innate |
T4695 | 7692-7694 | IN | denotes | in |
T4694 | 7687-7691 | NN | denotes | role |
T4693 | 7681-7686 | JJ | denotes | major |
T4692 | 7679-7680 | DT | denotes | a |
T4691 | 7673-7678 | VB | denotes | plays |
T4690 | 7665-7672 | NN | denotes | pathway |
T4689 | 7659-7664 | NN | denotes | NF-κB |
T4688 | 7649-7658 | JJ | denotes | canonical |
T4687 | 7645-7648 | DT | denotes | The |
T4686 | 7635-7643 | NN | denotes | pathways |
T4685 | 7629-7634 | NN | denotes | NF-κB |
T4684 | 7627-7628 | -RRB- | denotes | ) |
T4683 | 7616-7627 | JJ | denotes | alternative |
T4682 | 7613-7615 | CC | denotes | or |
T4681 | 7612-7613 | -LRB- | denotes | ( |
T4680 | 7599-7611 | JJ | denotes | noncanonical |
T4679 | 7595-7598 | CC | denotes | and |
T4678 | 7593-7594 | -RRB- | denotes | ) |
T4677 | 7584-7593 | JJ | denotes | classical |
T4676 | 7581-7583 | CC | denotes | or |
T4675 | 7580-7581 | -LRB- | denotes | ( |
T4674 | 7570-7579 | JJ | denotes | canonical |
T4673 | 7563-7569 | VB | denotes | termed |
T4672 | 7561-7562 | -COMMA- | denotes | , |
T4671 | 7553-7561 | NN | denotes | pathways |
T4670 | 7542-7552 | NN | denotes | signalling |
T4669 | 7536-7541 | NN | denotes | NF-κB |
T4668 | 7529-7535 | JJ | denotes | unique |
T4667 | 7525-7528 | CD | denotes | two |
T4666 | 7521-7524 | VB | denotes | are |
T4665 | 7515-7520 | EX | denotes | There |
T4664 | 7501-7513 | RB | denotes | respectively |
T4663 | 7499-7500 | -COMMA- | denotes | , |
T4662 | 7491-7499 | NN | denotes | subunits |
T4661 | 7485-7490 | NN | denotes | NF-κB |
T4660 | 7481-7484 | NN | denotes | p50 |
T4659 | 7477-7480 | CC | denotes | and |
T4658 | 7473-7476 | NN | denotes | p52 |
T4657 | 7469-7472 | DT | denotes | the |
T4656 | 7466-7468 | IN | denotes | of |
T2489 | 6982-6984 | NN | denotes | RA |
T2488 | 6979-6981 | IN | denotes | in |
T2487 | 6968-6978 | NN | denotes | expression |
T2486 | 6963-6967 | NN | denotes | gene |
T2485 | 6950-6962 | JJ | denotes | inflammatory |
T2484 | 6946-6949 | CC | denotes | and |
T2483 | 6935-6945 | NN | denotes | activation |
T2482 | 6929-6934 | NN | denotes | NF-κB |
T2481 | 6926-6928 | TO | denotes | to |
T2480 | 6915-6925 | VB | denotes | contribute |
T2479 | 6911-6914 | MD | denotes | may |
T2478 | 6904-6910 | NN | denotes | tissue |
T2477 | 6898-6903 | JJ | denotes | joint |
T2476 | 6889-6897 | JJ | denotes | inflamed |
T2475 | 6885-6888 | DT | denotes | the |
T2474 | 6882-6884 | IN | denotes | in |
T2473 | 6874-6881 | NN | denotes | ligands |
T2472 | 6870-6873 | NN | denotes | TLR |
T2471 | 6862-6869 | JJ | denotes | several |
T2470 | 6857-6861 | IN | denotes | that |
T2469 | 6849-6856 | VB | denotes | suggest |
T2468 | 6841-6848 | NN | denotes | studies |
T2467 | 6835-6840 | DT | denotes | these |
T2466 | 6833-6834 | -COMMA- | denotes | , |
T2465 | 6825-6833 | RB | denotes | Together |
T2464 | 6822-6823 | -RRB- | denotes | ) |
T2463 | 6821-6822 | -RRB- | denotes | ] |
T2462 | 6816-6821 | CD | denotes | 14,15 |
T2461 | 6815-6816 | -LRB- | denotes | [ |
T2460 | 6812-6814 | IN | denotes | in |
T2459 | 6803-6811 | VB | denotes | reviewed |
T2458 | 6802-6803 | -LRB- | denotes | ( |
T2457 | 6792-6801 | NN | denotes | fragments |
T2456 | 6787-6791 | NN | denotes | acid |
T2455 | 6775-6786 | JJ | denotes | hyal-uronic |
T2454 | 6771-6774 | CC | denotes | and |
T2453 | 6769-6770 | -COMMA- | denotes | , |
T2452 | 6768-6769 | NN | denotes | C |
T2451 | 6759-6767 | NN | denotes | tenascin |
T2450 | 6757-6758 | -COMMA- | denotes | , |
T2449 | 6749-6757 | NN | denotes | biglycan |
T2448 | 6747-6748 | -COMMA- | denotes | , |
T2447 | 6736-6747 | NN | denotes | fibronectin |
T2446 | 6734-6735 | -COMMA- | denotes | , |
T2445 | 6724-6734 | NN | denotes | fibrinogen |
T2444 | 6721-6723 | IN | denotes | as |
T2443 | 6716-6720 | JJ | denotes | such |
T2442 | 6705-6715 | NN | denotes | components |
T2441 | 6698-6704 | NN | denotes | matrix |
T2440 | 6684-6697 | JJ | denotes | extracellular |
T2439 | 6680-6683 | VB | denotes | are |
T2438 | 6670-6679 | NN | denotes | pathology |
T2437 | 6667-6669 | NN | denotes | RA |
T2436 | 6664-6666 | IN | denotes | in |
T2435 | 6655-6663 | VB | denotes | involved |
T2434 | 6652-6654 | VB | denotes | be |
T2433 | 6648-6651 | MD | denotes | may |
T2432 | 6643-6647 | WDT | denotes | that |
T2431 | 6635-6642 | NN | denotes | ligands |
T2430 | 6631-6634 | NN | denotes | TLR |
T2429 | 6620-6630 | JJ | denotes | endogenous |
T2428 | 6614-6619 | JJ | denotes | Other |
T2427 | 6611-6612 | -RRB- | denotes | ] |
T2426 | 6606-6611 | CD | denotes | 17,18 |
T2425 | 6605-6606 | -LRB- | denotes | [ |
T2424 | 6602-6604 | NN | denotes | RA |
T2423 | 6599-6601 | IN | denotes | in |
T2422 | 6586-6598 | NN | denotes | inflammation |
T2421 | 6578-6585 | JJ | denotes | chronic |
T2420 | 6565-6577 | JJ | denotes | TLR4-induced |
T2419 | 6562-6564 | IN | denotes | in |
T2418 | 6553-6561 | VB | denotes | involved |
T2047 | 4218-4221 | DT | denotes | the |
T2046 | 4215-4217 | IN | denotes | of |
T2045 | 4207-4214 | NN | denotes | Binding |
T2044 | 4204-4205 | -RRB- | denotes | ] |
T2043 | 4202-4204 | CD | denotes | 10 |
T2042 | 4201-4202 | -LRB- | denotes | [ |
T2041 | 4197-4200 | NN | denotes | TNF |
T2040 | 4187-4196 | VB | denotes | including |
T2039 | 4177-4186 | NN | denotes | cytokines |
T2038 | 4161-4176 | JJ | denotes | proinflammatory |
T2037 | 4158-4160 | IN | denotes | by |
T2036 | 4146-4157 | VB | denotes | upregulated |
T2035 | 4143-4145 | VB | denotes | be |
T2034 | 4139-4142 | MD | denotes | can |
T2033 | 4135-4138 | CC | denotes | and |
T2032 | 4133-4134 | -COMMA- | denotes | , |
T2031 | 4128-4133 | NN | denotes | cells |
T2030 | 4118-4127 | JJ | denotes | dendritic |
T2029 | 4114-4117 | CC | denotes | and |
T2028 | 4112-4113 | -COMMA- | denotes | , |
T2027 | 4101-4112 | NN | denotes | macrophages |
T2026 | 4099-4100 | -COMMA- | denotes | , |
T2025 | 4094-4099 | NN | denotes | cells |
T2024 | 4092-4093 | NN | denotes | B |
T2023 | 4090-4091 | -COMMA- | denotes | , |
T2022 | 4085-4090 | NN | denotes | cells |
T2021 | 4076-4084 | JJ | denotes | synovial |
T2020 | 4073-4075 | NN | denotes | RA |
T2019 | 4069-4072 | CC | denotes | and |
T2018 | 4060-4068 | NN | denotes | patients |
T2017 | 4057-4059 | NN | denotes | RA |
T2016 | 4053-4056 | CC | denotes | and |
T2015 | 4046-4052 | JJ | denotes | normal |
T2014 | 4041-4045 | IN | denotes | from |
T2013 | 4029-4040 | NN | denotes | fibroblasts |
T2012 | 4022-4028 | NN | denotes | muscle |
T2011 | 4015-4021 | JJ | denotes | smooth |
T2010 | 4005-4014 | VB | denotes | including |
T2009 | 4003-4004 | -COMMA- | denotes | , |
T2008 | 3998-4003 | NN | denotes | types |
T2007 | 3993-3997 | NN | denotes | cell |
T2006 | 3990-3992 | IN | denotes | of |
T2005 | 3982-3989 | NN | denotes | variety |
T2004 | 3980-3981 | DT | denotes | a |
T2003 | 3977-3979 | IN | denotes | on |
T2002 | 3967-3976 | VB | denotes | expressed |
T2001 | 3954-3966 | RB | denotes | functionally |
T2000 | 3951-3953 | VB | denotes | is |
T1999 | 3946-3950 | WDT | denotes | that |
T1998 | 3939-3945 | NN | denotes | member |
T1997 | 3932-3938 | NN | denotes | family |
T1996 | 3923-3931 | NN | denotes | receptor |
T1995 | 3919-3922 | NN | denotes | TNF |
T1994 | 3911-3918 | DT | denotes | another |
T1993 | 3908-3910 | VB | denotes | is |
T1992 | 3903-3907 | NN | denotes | CD40 |
T1991 | 3900-3901 | -RRB- | denotes | ] |
T1990 | 3899-3900 | CD | denotes | 7 |
T1989 | 3898-3899 | -LRB- | denotes | [ |
T1988 | 3893-3897 | NN | denotes | loss |
T1987 | 3888-3892 | NN | denotes | bone |
T1986 | 3883-3887 | IN | denotes | with |
T1985 | 3872-3882 | VB | denotes | associated |
T1984 | 3863-3871 | NN | denotes | diseases |
T1983 | 3857-3862 | JJ | denotes | other |
T1982 | 3853-3856 | CC | denotes | and |
T1981 | 3843-3852 | NN | denotes | pathology |
T1980 | 3840-3842 | NN | denotes | RA |
T1979 | 3837-3839 | IN | denotes | in |
T1978 | 3828-3836 | VB | denotes | involved |
T1977 | 3825-3827 | VB | denotes | be |
T1976 | 3822-3824 | TO | denotes | to |
T1975 | 3815-3821 | JJ | denotes | likely |
T1974 | 3811-3814 | VB | denotes | are |
T1973 | 3800-3810 | NN | denotes | signalling |
T1972 | 3789-3799 | NN | denotes | RANK-NF-κB |
T1971 | 3782-3788 | JJ | denotes | proper |
T1970 | 3779-3781 | IN | denotes | in |
T1969 | 3771-3778 | NN | denotes | defects |
T1968 | 3767-3770 | CC | denotes | and |
T1967 | 3765-3766 | -COMMA- | denotes | , |
T1966 | 3747-3765 | NN | denotes | osteoclastogenesis |
T1965 | 3743-3746 | IN | denotes | for |
T1964 | 3733-3742 | JJ | denotes | important |
T1963 | 3730-3732 | VB | denotes | is |
T1962 | 3728-3729 | -COMMA- | denotes | , |
T1961 | 3722-3728 | NN | denotes | member |
T1960 | 3715-3721 | NN | denotes | family |
T1959 | 3706-3714 | NN | denotes | receptor |
T1958 | 3702-3705 | NN | denotes | TNF |
T1957 | 3700-3701 | DT | denotes | a |
T1956 | 3698-3699 | -COMMA- | denotes | , |
T1955 | 3697-3698 | -RRB- | denotes | ) |
T1954 | 3693-3697 | NN | denotes | RANK |
T1953 | 3692-3693 | -LRB- | denotes | ( |
T1952 | 3686-3691 | NN | denotes | NF-κB |
T1951 | 3683-3685 | IN | denotes | of |
T1950 | 3673-3682 | NN | denotes | activator |
T1949 | 3664-3672 | NN | denotes | receptor |
T1948 | 3661-3663 | IN | denotes | by |
T1947 | 3650-3660 | NN | denotes | activation |
T1946 | 3644-3649 | NN | denotes | NF-κB |
T1945 | 3641-3642 | -RRB- | denotes | ) |
T1944 | 3640-3641 | -RRB- | denotes | ] |
T1943 | 3639-3640 | CD | denotes | 3 |
T1942 | 3638-3639 | -LRB- | denotes | [ |
T1941 | 3635-3637 | IN | denotes | in |
T1940 | 3626-3634 | VB | denotes | reviewed |
T1939 | 3625-3626 | -LRB- | denotes | ( |
T1938 | 3622-3624 | NN | denotes | RA |
T1937 | 3619-3621 | IN | denotes | in |
T1936 | 3608-3618 | NN | denotes | activities |
T1935 | 3591-3607 | JJ | denotes | pro-inflammatory |
T1934 | 3585-3590 | PRP-DOLLAR- | denotes | their |
T1933 | 3582-3584 | IN | denotes | of |
T1932 | 3577-3581 | JJ | denotes | most |
T1931 | 3568-3576 | VB | denotes | mediates |
T1930 | 3558-3567 | NN | denotes | cytokines |
T1929 | 3552-3557 | DT | denotes | these |
T1928 | 3549-3551 | IN | denotes | by |
T1927 | 3538-3548 | NN | denotes | activation |
T1926 | 3532-3537 | NN | denotes | NF-κB |
T1925 | 3527-3531 | IN | denotes | that |
T1924 | 3518-3526 | VB | denotes | expected |
T1923 | 3515-3517 | VB | denotes | be |
T1922 | 3511-3514 | MD | denotes | can |
T1921 | 3508-3510 | PRP | denotes | it |
T1920 | 3504-3507 | CC | denotes | and |
T1919 | 3498-3503 | NN | denotes | NF-κB |
T1918 | 3495-3497 | IN | denotes | of |
T1917 | 3484-3494 | NN | denotes | activators |
T1916 | 3477-3483 | JJ | denotes | potent |
T1915 | 3472-3476 | RB | denotes | very |
T1914 | 3467-3471 | DT | denotes | both |
T1913 | 3463-3466 | VB | denotes | are |
T1912 | 3458-3462 | NN | denotes | IL-1 |
T1911 | 3454-3457 | CC | denotes | and |
T1910 | 3450-3453 | NN | denotes | TNF |
T1909 | 3447-3448 | -RRB- | denotes | ) |
T1908 | 3446-3447 | -RRB- | denotes | ] |
T1907 | 3445-3446 | CD | denotes | 9 |
T1906 | 3444-3445 | -LRB- | denotes | [ |
T1905 | 3441-3443 | IN | denotes | in |
T1904 | 3432-3440 | VB | denotes | reviewed |
T1903 | 3431-3432 | -LRB- | denotes | ( |
T1902 | 3428-3430 | NN | denotes | RA |
T1901 | 3421-3427 | JJ | denotes | severe |
T1900 | 3417-3420 | IN | denotes | for |
T1899 | 3407-3416 | NN | denotes | treatment |
T1898 | 3397-3406 | JJ | denotes | effective |
T1897 | 3394-3396 | DT | denotes | an |
T1896 | 3391-3393 | VB | denotes | is |
T1895 | 3379-3390 | NN | denotes | antagonists |
T1894 | 3375-3378 | NN | denotes | TNF |
T1893 | 3372-3374 | IN | denotes | of |
T1892 | 3357-3371 | NN | denotes | administration |
T1891 | 3353-3356 | CC | denotes | and |
T1890 | 3351-3352 | -COMMA- | denotes | , |
T1889 | 3347-3351 | NN | denotes | role |
T1888 | 3337-3346 | JJ | denotes | important |
T1887 | 3334-3336 | DT | denotes | an |
T1886 | 3329-3333 | VB | denotes | play |
T1885 | 3324-3328 | NN | denotes | IL-1 |
T1884 | 3320-3323 | CC | denotes | and |
T1883 | 3316-3319 | NN | denotes | TNF |
T1882 | 3313-3315 | IN | denotes | as |
T1881 | 3308-3312 | JJ | denotes | such |
T1880 | 3298-3307 | NN | denotes | cytokines |
T1879 | 3282-3297 | JJ | denotes | proinflammatory |
T1878 | 3277-3281 | IN | denotes | that |
T1877 | 3268-3276 | VB | denotes | accepted |
T1876 | 3263-3267 | RB | denotes | well |
T1875 | 3260-3262 | VB | denotes | is |
T1874 | 3257-3259 | PRP | denotes | It |
T1873 | 3253-3255 | NN | denotes | RA |
T1872 | 3250-3252 | IN | denotes | in |
T1871 | 3244-3249 | NN | denotes | NF-κB |
T1870 | 3235-3243 | VB | denotes | activate |
T1869 | 3230-3234 | WDT | denotes | that |
T1868 | 3221-3229 | NN | denotes | triggers |
T1867 | 3211-3220 | JJ | denotes | molecular |
T1866 | 3207-3210 | DT | denotes | the |
T1865 | 3204-3206 | IN | denotes | of |
T1864 | 3189-3203 | NN | denotes | identification |
T1863 | 3185-3188 | DT | denotes | the |
T1862 | 3180-3184 | IN | denotes | with |
T1861 | 3174-3179 | NN | denotes | deals |
T1860 | 3165-3173 | NN | denotes | research |
T1859 | 3160-3164 | JJ | denotes | much |
T1858 | 3158-3159 | -COMMA- | denotes | , |
T1857 | 3156-3158 | NN | denotes | RA |
T1856 | 3153-3155 | IN | denotes | in |
T1855 | 3140-3152 | NN | denotes | inflammation |
T1854 | 3137-3139 | IN | denotes | of |
T1853 | 3129-3136 | NN | denotes | process |
T1852 | 3125-3128 | DT | denotes | the |
T1851 | 3122-3124 | TO | denotes | to |
T1850 | 3114-3121 | JJ | denotes | central |
T1849 | 3111-3113 | VB | denotes | is |
T1848 | 3105-3110 | NN | denotes | NF-κB |
T1847 | 3099-3104 | IN | denotes | Since |
T2417 | 6550-6552 | VB | denotes | be |
T2416 | 6547-6549 | TO | denotes | to |
T2415 | 6537-6546 | VB | denotes | suggested |
T2414 | 6532-6536 | VB | denotes | been |
T2413 | 6527-6531 | VB | denotes | have |
T2412 | 6523-6526 | CC | denotes | and |
T2411 | 6521-6522 | -COMMA- | denotes | , |
T2410 | 6516-6521 | NN | denotes | fluid |
T2409 | 6507-6515 | JJ | denotes | synovial |
T2408 | 6504-6506 | NN | denotes | RA |
T2407 | 6501-6503 | IN | denotes | in |
T2406 | 6493-6500 | JJ | denotes | present |
T2405 | 6482-6492 | RB | denotes | abundantly |
T2404 | 6477-6481 | RB | denotes | also |
T2403 | 6473-6476 | VB | denotes | are |
T2402 | 6471-6472 | -COMMA- | denotes | , |
T2401 | 6463-6471 | NN | denotes | proteins |
T2400 | 6447-6462 | JJ | denotes | calcium-binding |
T2399 | 6444-6446 | IN | denotes | of |
T2398 | 6437-6443 | NN | denotes | family |
T2397 | 6432-6436 | NN | denotes | S100 |
T2396 | 6428-6431 | DT | denotes | the |
T2395 | 6425-6427 | TO | denotes | to |
T2394 | 6415-6424 | VB | denotes | belonging |
T2393 | 6405-6414 | NN | denotes | molecules |
T2392 | 6397-6404 | NN | denotes | pattern |
T2391 | 6387-6396 | JJ | denotes | molecular |
T2390 | 6369-6386 | JJ | denotes | damage-associated |
T2389 | 6367-6368 | -COMMA- | denotes | , |
T2388 | 6365-6367 | CD | denotes | 14 |
T2387 | 6357-6364 | NN | denotes | protein |
T2386 | 6341-6356 | JJ | denotes | myeloid-related |
T2385 | 6337-6340 | CC | denotes | and |
T2384 | 6335-6336 | CD | denotes | 8 |
T2383 | 6327-6334 | NN | denotes | protein |
T2382 | 6311-6326 | JJ | denotes | Myeloid-related |
T2381 | 6308-6309 | -RRB- | denotes | ] |
T2380 | 6306-6308 | CD | denotes | 16 |
T2379 | 6305-6306 | -LRB- | denotes | [ |
T2378 | 6300-6304 | NN | denotes | mice |
T2377 | 6297-6299 | IN | denotes | in |
T2376 | 6287-6296 | NN | denotes | arthritis |
T2375 | 6270-6286 | JJ | denotes | collagen-induced |
T2374 | 6262-6269 | IN | denotes | against |
T2373 | 6254-6261 | NN | denotes | protect |
T2372 | 6248-6253 | NN | denotes | HMGB1 |
T2371 | 6245-6247 | IN | denotes | of |
T2370 | 6238-6244 | NN | denotes | domain |
T2369 | 6233-6237 | NN | denotes | BoxA |
T2368 | 6220-6232 | JJ | denotes | antagonistic |
T2367 | 6216-6219 | DT | denotes | the |
T2366 | 6213-6215 | CC | denotes | or |
T2365 | 6202-6212 | NN | denotes | antibodies |
T2364 | 6189-6201 | VB | denotes | neutralising |
T2363 | 6183-6188 | NN | denotes | HMGB1 |
T2362 | 6179-6182 | CC | denotes | and |
T2361 | 6172-6178 | NN | denotes | tissue |
T2360 | 6163-6171 | JJ | denotes | synovial |
T2359 | 6160-6162 | NN | denotes | RA |
T2358 | 6157-6159 | IN | denotes | in |
T2357 | 6147-6156 | VB | denotes | increased |
T2356 | 6144-6146 | VB | denotes | is |
T2355 | 6138-6143 | NN | denotes | HMGB1 |
T2354 | 6127-6136 | NN | denotes | pathology |
T2353 | 6124-6126 | NN | denotes | RA |
T2352 | 6121-6123 | IN | denotes | in |
T2351 | 6112-6120 | VB | denotes | involved |
T2350 | 6104-6111 | NN | denotes | ligands |
T2349 | 6099-6103 | NN | denotes | TLR4 |
T2348 | 6088-6098 | JJ | denotes | endogenous |
T2347 | 6079-6087 | JJ | denotes | putative |
T2346 | 6074-6078 | RB | denotes | most |
T2345 | 6070-6073 | DT | denotes | the |
T2344 | 6067-6069 | IN | denotes | of |
T2343 | 6063-6066 | CD | denotes | one |
T2342 | 6060-6062 | VB | denotes | is |
T2341 | 6058-6059 | -COMMA- | denotes | , |
T2340 | 6053-6058 | NN | denotes | cells |
T2339 | 6044-6052 | JJ | denotes | necrotic |
T2338 | 6041-6043 | IN | denotes | by |
T2337 | 6032-6040 | VB | denotes | released |
T2336 | 6022-6031 | RB | denotes | passively |
T2335 | 6019-6021 | CC | denotes | or |
T2334 | 6007-6018 | NN | denotes | macrophages |
T2333 | 6004-6006 | IN | denotes | by |
T2332 | 5995-6003 | VB | denotes | secreted |
T2331 | 5986-5994 | RB | denotes | actively |
T2330 | 5983-5985 | VB | denotes | be |
T2329 | 5979-5982 | MD | denotes | can |
T2328 | 5974-5978 | WDT | denotes | that |
T2327 | 5964-5973 | NN | denotes | component |
T2326 | 5954-5963 | NN | denotes | chromatin |
T2325 | 5944-5953 | VB | denotes | conserved |
T2324 | 5937-5943 | RB | denotes | highly |
T2323 | 5935-5936 | DT | denotes | a |
T2322 | 5933-5934 | -COMMA- | denotes | , |
T2321 | 5932-5933 | -RRB- | denotes | ) |
T2320 | 5927-5932 | NN | denotes | HMGB1 |
T2319 | 5926-5927 | -LRB- | denotes | ( |
T2318 | 5924-5925 | CD | denotes | 1 |
T2317 | 5916-5923 | NN | denotes | protein |
T2316 | 5904-5915 | JJ | denotes | chromosomal |
T2315 | 5900-5903 | NN | denotes | box |
T2314 | 5894-5899 | NN | denotes | group |
T2313 | 5885-5893 | NN | denotes | mobility |
T2312 | 5880-5884 | JJ | denotes | High |
T2311 | 5871-5878 | NN | denotes | disease |
T2310 | 5867-5870 | DT | denotes | the |
T2309 | 5864-5866 | IN | denotes | of |
T2308 | 5851-5863 | NN | denotes | pathogenesis |
T2307 | 5847-5850 | DT | denotes | the |
T2306 | 5844-5846 | IN | denotes | in |
T2305 | 5834-5843 | JJ | denotes | important |
T2304 | 5828-5833 | VB | denotes | being |
T2303 | 5825-5827 | IN | denotes | as |
T2302 | 5812-5824 | NN | denotes | inflammation |
T2301 | 5798-5811 | JJ | denotes | TLR-dependent |
T2300 | 5789-5797 | VB | denotes | identify |
T2299 | 5781-5788 | RB | denotes | clearly |
T2298 | 5770-5780 | NN | denotes | signalling |
T2297 | 5766-5769 | NN | denotes | TLR |
T2296 | 5760-5765 | VB | denotes | block |
T2295 | 5757-5759 | TO | denotes | to |
T2294 | 5746-5756 | NN | denotes | strategies |
T2293 | 5743-5745 | CC | denotes | or |
T2292 | 5738-5742 | NN | denotes | mice |
T2291 | 5729-5737 | NN | denotes | knockout |
T2290 | 5725-5728 | NN | denotes | TLR |
T2289 | 5719-5724 | VB | denotes | using |
T2288 | 5712-5718 | NN | denotes | models |
T2287 | 5705-5711 | NN | denotes | animal |
T2286 | 5703-5704 | -COMMA- | denotes | , |
T2285 | 5695-5703 | RB | denotes | Moreover |
T2284 | 5685-5693 | NN | denotes | patients |
T2283 | 5682-5684 | NN | denotes | RA |
T2282 | 5679-5681 | IN | denotes | of |
T2281 | 5672-5678 | NN | denotes | joints |
T2280 | 5663-5671 | JJ | denotes | inflamed |
T2279 | 5659-5662 | DT | denotes | the |
T2278 | 5652-5658 | IN | denotes | within |
T2277 | 5644-5651 | JJ | denotes | present |
T2276 | 5640-5643 | VB | denotes | are |
T2275 | 5632-5639 | NN | denotes | ligands |
T2274 | 5621-5631 | JJ | denotes | endogenous |
T2273 | 5613-5620 | JJ | denotes | various |
T2272 | 5609-5612 | CC | denotes | and |
T2237 | 5403-5405 | IN | denotes | of |
T2236 | 5397-5402 | NN | denotes | group |
T2235 | 5395-5396 | DT | denotes | a |
T2234 | 5393-5394 | -COLON- | denotes | - |
T2233 | 5385-5392 | NN | denotes | ligands |
T2232 | 5374-5384 | JJ | denotes | endogenous |
T2231 | 5371-5373 | IN | denotes | of |
T2230 | 5364-5370 | NN | denotes | number |
T2229 | 5353-5363 | VB | denotes | increasing |
T2228 | 5350-5352 | DT | denotes | an |
T2227 | 5348-5349 | -COMMA- | denotes | , |
T2226 | 5341-5348 | NN | denotes | ligands |
T2225 | 5331-5340 | JJ | denotes | microbial |
T2224 | 5328-5330 | TO | denotes | to |
T2223 | 5319-5327 | NN | denotes | addition |
T2222 | 5316-5318 | IN | denotes | In |
T2221 | 5312-5314 | NN | denotes | RA |
T2220 | 5309-5311 | IN | denotes | in |
T2219 | 5296-5308 | NN | denotes | inflammation |
T2218 | 5280-5295 | JJ | denotes | NF-κB-dependent |
T2217 | 5271-5279 | VB | denotes | inducing |
T2216 | 5267-5270 | IN | denotes | for |
T2215 | 5256-5266 | NN | denotes | candidates |
T2214 | 5246-5255 | JJ | denotes | potential |
T2213 | 5242-5245 | VB | denotes | are |
T2212 | 5238-5241 | CC | denotes | and |
T2211 | 5229-5237 | NN | denotes | diseases |
T2210 | 5218-5228 | JJ | denotes | autoimmune |
T2209 | 5215-5217 | IN | denotes | of |
T2208 | 5207-5214 | NN | denotes | variety |
T2207 | 5205-5206 | DT | denotes | a |
T2206 | 5202-5204 | IN | denotes | in |
T2205 | 5191-5201 | VB | denotes | implicated |
T2204 | 5186-5190 | VB | denotes | been |
T2203 | 5181-5185 | VB | denotes | have |
T2202 | 5179-5180 | -RRB- | denotes | ) |
T2201 | 5175-5179 | NN | denotes | TLRs |
T2200 | 5174-5175 | -LRB- | denotes | ( |
T2199 | 5164-5173 | NN | denotes | receptors |
T2198 | 5154-5163 | JJ | denotes | Toll-like |
T2197 | 5151-5152 | -RRB- | denotes | ] |
T2196 | 5149-5151 | CD | denotes | 13 |
T2195 | 5148-5149 | -LRB- | denotes | [ |
T2194 | 5145-5147 | NN | denotes | RA |
T2193 | 5135-5144 | VB | denotes | including |
T2192 | 5122-5134 | NN | denotes | inflammation |
T2191 | 5114-5121 | JJ | denotes | chronic |
T2190 | 5111-5113 | IN | denotes | of |
T2189 | 5105-5110 | NN | denotes | sites |
T2188 | 5102-5104 | IN | denotes | at |
T2187 | 5092-5101 | NN | denotes | formation |
T2186 | 5086-5091 | NN | denotes | organ |
T2185 | 5077-5085 | JJ | denotes | lymphoid |
T2184 | 5068-5076 | JJ | denotes | tertiary |
T2183 | 5065-5067 | IN | denotes | in |
T2182 | 5054-5064 | VB | denotes | implicated |
T2181 | 5049-5053 | VB | denotes | been |
T2180 | 5045-5048 | VB | denotes | has |
T2179 | 5034-5044 | NN | denotes | signalling |
T2178 | 5025-5033 | NN | denotes | receptor |
T2177 | 5023-5024 | NN | denotes | β |
T2176 | 5011-5022 | NN | denotes | lymphotoxin |
T2175 | 5009-5010 | -COMMA- | denotes | , |
T2174 | 5002-5009 | RB | denotes | Finally |
T2173 | 4999-5000 | -RRB- | denotes | ] |
T2172 | 4997-4999 | CD | denotes | 13 |
T2171 | 4996-4997 | -LRB- | denotes | [ |
T2170 | 4993-4995 | NN | denotes | RA |
T2169 | 4985-4992 | VB | denotes | counter |
T2168 | 4982-4984 | TO | denotes | to |
T2167 | 4972-4981 | VB | denotes | developed |
T2166 | 4967-4971 | VB | denotes | been |
T2165 | 4962-4966 | VB | denotes | have |
T2164 | 4957-4961 | NN | denotes | BAFF |
T2163 | 4954-4956 | IN | denotes | of |
T2162 | 4942-4953 | NN | denotes | antagonists |
T2161 | 4938-4941 | CC | denotes | and |
T2160 | 4936-4937 | -COMMA- | denotes | , |
T2159 | 4934-4936 | NN | denotes | RA |
T2158 | 4930-4933 | IN | denotes | for |
T2157 | 4915-4929 | JJ | denotes | characteristic |
T2156 | 4910-4914 | RB | denotes | also |
T2155 | 4907-4909 | VB | denotes | is |
T2154 | 4905-4906 | -COMMA- | denotes | , |
T2153 | 4894-4905 | NN | denotes | lymphocytes |
T2152 | 4892-4893 | NN | denotes | B |
T2151 | 4882-4891 | VB | denotes | producing |
T2150 | 4868-4881 | NN | denotes | autoantibody- |
T2149 | 4865-4867 | IN | denotes | of |
T2148 | 4856-4864 | NN | denotes | survival |
T2147 | 4852-4855 | DT | denotes | the |
T2146 | 4843-4851 | VB | denotes | allowing |
T2145 | 4841-4842 | -COMMA- | denotes | , |
T2144 | 4840-4841 | -RRB- | denotes | ) |
T2143 | 4836-4840 | NN | denotes | BAFF |
T2142 | 4835-4836 | -LRB- | denotes | ( |
T2141 | 4828-4834 | NN | denotes | factor |
T2140 | 4817-4827 | VB | denotes | activating |
T2139 | 4810-4816 | NN | denotes | B-cell |
T2138 | 4803-4809 | NN | denotes | member |
T2137 | 4796-4802 | NN | denotes | family |
T2136 | 4787-4795 | NN | denotes | receptor |
T2135 | 4783-4786 | NN | denotes | TNF |
T2134 | 4779-4782 | DT | denotes | the |
T2133 | 4776-4778 | IN | denotes | of |
T2132 | 4765-4775 | NN | denotes | expression |
T2131 | 4756-4764 | VB | denotes | Enhanced |
T2130 | 4753-4754 | -RRB- | denotes | ] |
T2129 | 4748-4753 | CD | denotes | 11,12 |
T2128 | 4747-4748 | -LRB- | denotes | [ |
T2127 | 4739-4746 | JJ | denotes | present |
T2126 | 4731-4738 | RB | denotes | already |
T2125 | 4727-4730 | VB | denotes | are |
T2124 | 4716-4726 | NN | denotes | antibodies |
T2123 | 4705-4715 | JJ | denotes | pathogenic |
T2122 | 4701-4704 | CC | denotes | and |
T2121 | 4689-4700 | VB | denotes | established |
T2120 | 4686-4688 | VB | denotes | is |
T2119 | 4678-4685 | NN | denotes | disease |
T2118 | 4673-4677 | RB | denotes | once |
T2117 | 4664-4672 | VB | denotes | required |
T2116 | 4660-4663 | RB | denotes | not |
T2115 | 4656-4659 | VB | denotes | are |
T2114 | 4652-4655 | CC | denotes | but |
T2113 | 4650-4651 | -COMMA- | denotes | , |
T2112 | 4641-4650 | NN | denotes | induction |
T2111 | 4631-4640 | NN | denotes | arthritis |
T2110 | 4628-4630 | IN | denotes | of |
T2109 | 4621-4627 | NN | denotes | stages |
T2108 | 4613-4620 | JJ | denotes | initial |
T2107 | 4609-4612 | DT | denotes | the |
T2106 | 4606-4608 | IN | denotes | at |
T2105 | 4596-4605 | JJ | denotes | important |
T2104 | 4593-4595 | VB | denotes | be |
T2103 | 4589-4592 | MD | denotes | may |
T2102 | 4581-4588 | NN | denotes | signals |
T2101 | 4576-4580 | NN | denotes | CD40 |
T2100 | 4571-4575 | IN | denotes | that |
T2099 | 4560-4570 | NN | denotes | conclusion |
T2098 | 4556-4559 | DT | denotes | the |
T2097 | 4553-4555 | TO | denotes | to |
T2096 | 4549-4552 | VB | denotes | led |
T2095 | 4538-4548 | NN | denotes | antibodies |
T2094 | 4527-4537 | JJ | denotes | anti-CD154 |
T2093 | 4524-4526 | CC | denotes | or |
T2092 | 4514-4523 | NN | denotes | anti-CD40 |
T2091 | 4501-4513 | JJ | denotes | antagonistic |
T2090 | 4496-4500 | IN | denotes | with |
T2089 | 4488-4495 | NN | denotes | studies |
T2088 | 4486-4487 | -COMMA- | denotes | , |
T2087 | 4479-4486 | RB | denotes | However |
T2086 | 4466-4477 | NN | denotes | destruction |
T2085 | 4460-4465 | JJ | denotes | joint |
T2084 | 4457-4459 | TO | denotes | to |
T2083 | 4445-4456 | VB | denotes | contributes |
T2082 | 4439-4444 | WDT | denotes | which |
T2081 | 4437-4438 | -COMMA- | denotes | , |
T2080 | 4427-4437 | NN | denotes | chemokines |
T2079 | 4423-4426 | CC | denotes | and |
T2078 | 4413-4422 | NN | denotes | cytokines |
T2077 | 4397-4412 | JJ | denotes | proinflammatory |
T2076 | 4394-4396 | IN | denotes | of |
T2075 | 4384-4393 | NN | denotes | secretion |
T2074 | 4380-4383 | CC | denotes | and |
T2073 | 4366-4379 | NN | denotes | proliferation |
T2072 | 4355-4365 | NN | denotes | fibroblast |
T2071 | 4352-4354 | IN | denotes | in |
T2070 | 4342-4351 | VB | denotes | resulting |
T2069 | 4331-4341 | NN | denotes | activation |
T2068 | 4325-4330 | NN | denotes | NF-κB |
T2067 | 4316-4324 | VB | denotes | triggers |
T2066 | 4314-4315 | -COMMA- | denotes | , |
T2065 | 4309-4314 | NN | denotes | cells |
T2064 | 4307-4308 | NN | denotes | T |
T2063 | 4302-4306 | JJ | denotes | CD4+ |
T2062 | 4292-4301 | VB | denotes | activated |
T2061 | 4289-4291 | IN | denotes | of |
T2060 | 4281-4288 | NN | denotes | surface |
T2059 | 4277-4280 | DT | denotes | the |
T2058 | 4274-4276 | IN | denotes | on |
T2057 | 4264-4273 | VB | denotes | expressed |
T2056 | 4252-4263 | RB | denotes | transiently |
T2055 | 4249-4251 | VB | denotes | is |
T2054 | 4243-4248 | WDT | denotes | which |
T2053 | 4241-4242 | -COMMA- | denotes | , |
T2052 | 4240-4241 | -RRB- | denotes | ) |
T2051 | 4235-4240 | NN | denotes | CD154 |
T2050 | 4234-4235 | -LRB- | denotes | ( |
T2049 | 4227-4233 | NN | denotes | ligand |
T2048 | 4222-4226 | NN | denotes | CD40 |
T2271 | 5601-5608 | NN | denotes | tissues |
T2270 | 5592-5600 | JJ | denotes | synovial |
T2269 | 5589-5591 | NN | denotes | RA |
T2268 | 5586-5588 | IN | denotes | in |
T2267 | 5576-5585 | VB | denotes | expressed |
T2266 | 5572-5575 | VB | denotes | are |
T2265 | 5567-5571 | NN | denotes | TLRs |
T2264 | 5564-5565 | -RRB- | denotes | ) |
T2263 | 5563-5564 | -RRB- | denotes | ] |
T2262 | 5558-5563 | CD | denotes | 14,15 |
T2261 | 5557-5558 | -LRB- | denotes | [ |
T2260 | 5554-5556 | IN | denotes | in |
T2259 | 5545-5553 | VB | denotes | reviewed |
T2258 | 5544-5545 | -LRB- | denotes | ( |
T2257 | 5531-5543 | NN | denotes | inflammation |
T2256 | 5523-5530 | JJ | denotes | sterile |
T2255 | 5513-5522 | JJ | denotes | so-called |
T2254 | 5504-5512 | VB | denotes | inducing |
T2253 | 5499-5503 | NN | denotes | TLRs |
T2252 | 5496-5498 | IN | denotes | of |
T2251 | 5485-5495 | NN | denotes | activators |
T2250 | 5475-5484 | NN | denotes | candidate |
T2249 | 5472-5474 | IN | denotes | as |
T2248 | 5463-5471 | VB | denotes | reported |
T2247 | 5458-5462 | VB | denotes | been |
T2246 | 5453-5457 | VB | denotes | have |
T2245 | 5451-5452 | -COLON- | denotes | - |
T2244 | 5445-5450 | NN | denotes | cells |
T2243 | 5441-5444 | CC | denotes | and |
T2242 | 5433-5440 | NN | denotes | tissues |
T2241 | 5428-5432 | NN | denotes | host |
T2240 | 5423-5427 | IN | denotes | from |
T2239 | 5415-5422 | VB | denotes | derived |
T2238 | 5406-5414 | NN | denotes | proteins |
T718 | 2709-2712 | DT | denotes | the |
T776 | 3047-3048 | -RRB- | denotes | ] |
T774 | 3045-3046 | -LRB- | denotes | [ |
T773 | 3032-3044 | NN | denotes | pathogenesis |
T772 | 3029-3031 | NN | denotes | RA |
T771 | 3026-3028 | IN | denotes | in |
T770 | 3015-3025 | NN | denotes | activation |
T769 | 3009-3014 | NN | denotes | NF-κB |
T768 | 3006-3008 | IN | denotes | of |
T767 | 2995-3005 | NN | denotes | importance |
T766 | 2991-2994 | DT | denotes | the |
T765 | 2981-2990 | VB | denotes | highlight |
T764 | 2973-2980 | RB | denotes | further |
T763 | 2971-2972 | -COMMA- | denotes | , |
T762 | 2966-2971 | NN | denotes | c-REL |
T761 | 2962-2965 | CC | denotes | and |
T760 | 2960-2961 | -COMMA- | denotes | , |
T759 | 2953-2960 | NN | denotes | TNFAIP3 |
T758 | 2951-2952 | -COMMA- | denotes | , |
T757 | 2946-2951 | NN | denotes | TRAF1 |
T756 | 2944-2945 | -COMMA- | denotes | , |
T755 | 2940-2944 | NN | denotes | CD40 |
T754 | 2930-2939 | VB | denotes | including |
T753 | 2928-2929 | -COMMA- | denotes | , |
T752 | 2918-2928 | NN | denotes | signalling |
T751 | 2912-2917 | NN | denotes | NF-κB |
T750 | 2909-2911 | TO | denotes | to |
T749 | 2900-2908 | JJ | denotes | relevant |
T748 | 2894-2899 | NN | denotes | genes |
T747 | 2886-2893 | JJ | denotes | several |
T746 | 2881-2885 | IN | denotes | with |
T745 | 2869-2880 | NN | denotes | association |
T744 | 2861-2868 | JJ | denotes | genetic |
T743 | 2859-2860 | DT | denotes | a |
T742 | 2849-2858 | VB | denotes | revealing |
T741 | 2837-2848 | NN | denotes | discoveries |
T740 | 2830-2836 | JJ | denotes | recent |
T739 | 2828-2829 | -COMMA- | denotes | , |
T738 | 2821-2828 | RB | denotes | Finally |
T737 | 2818-2819 | -RRB- | denotes | ] |
T736 | 2817-2818 | CD | denotes | 7 |
T735 | 2816-2817 | -LRB- | denotes | [ |
T734 | 2813-2815 | NN | denotes | RA |
T733 | 2810-2812 | IN | denotes | as |
T732 | 2805-2809 | JJ | denotes | such |
T731 | 2796-2804 | NN | denotes | diseases |
T730 | 2785-2795 | JJ | denotes | osteolytic |
T729 | 2782-2784 | IN | denotes | in |
T728 | 2774-2781 | NN | denotes | erosion |
T727 | 2769-2773 | NN | denotes | bone |
T726 | 2766-2768 | IN | denotes | of |
T725 | 2760-2765 | NN | denotes | cause |
T724 | 2754-2759 | JJ | denotes | major |
T723 | 2750-2753 | DT | denotes | the |
T722 | 2746-2749 | VB | denotes | are |
T721 | 2727-2745 | NN | denotes | osteoclastogenesis |
T720 | 2724-2726 | IN | denotes | of |
T719 | 2713-2723 | NN | denotes | regulation |
T717 | 2706-2708 | IN | denotes | in |
T716 | 2698-2705 | NN | denotes | Defects |
T715 | 2695-2696 | -RRB- | denotes | ) |
T714 | 2690-2695 | NN | denotes | RANKL |
T713 | 2689-2690 | -LRB- | denotes | ( |
T712 | 2682-2688 | NN | denotes | ligand |
T711 | 2676-2681 | NN | denotes | NF-κB |
T710 | 2673-2675 | IN | denotes | of |
T709 | 2663-2672 | NN | denotes | activator |
T708 | 2654-2662 | NN | denotes | receptor |
T707 | 2651-2653 | IN | denotes | of |
T706 | 2643-2650 | NN | denotes | effects |
T705 | 2639-2642 | DT | denotes | the |
T704 | 2629-2638 | VB | denotes | mediating |
T703 | 2626-2628 | IN | denotes | by |
T702 | 2619-2625 | RB | denotes | mainly |
T701 | 2617-2618 | -COMMA- | denotes | , |
T700 | 2599-2617 | NN | denotes | osteoclastogenesis |
T699 | 2595-2598 | IN | denotes | for |
T698 | 2585-2594 | JJ | denotes | essential |
T697 | 2580-2584 | RB | denotes | also |
T696 | 2577-2579 | VB | denotes | is |
T695 | 2571-2576 | NN | denotes | NF-κB |
T694 | 2569-2570 | -COMMA- | denotes | , |
T693 | 2559-2569 | NN | denotes | expression |
T668 | 2421-2424 | DT | denotes | the |
T667 | 2413-2420 | VB | denotes | precede |
T666 | 2410-2412 | TO | denotes | to |
T665 | 2402-2409 | VB | denotes | appears |
T664 | 2391-2401 | NN | denotes | activation |
T663 | 2385-2390 | NN | denotes | NF-κB |
T662 | 2382-2384 | IN | denotes | of |
T661 | 2375-2381 | NN | denotes | course |
T660 | 2370-2374 | NN | denotes | time |
T659 | 2366-2369 | DT | denotes | The |
T658 | 2363-2364 | -RRB- | denotes | ) |
T657 | 2362-2363 | -RRB- | denotes | ] |
T656 | 2361-2362 | CD | denotes | 4 |
T655 | 2360-2361 | -LRB- | denotes | [ |
T654 | 2357-2359 | IN | denotes | in |
T653 | 2348-2356 | VB | denotes | reviewed |
T652 | 2347-2348 | -LRB- | denotes | ( |
T651 | 2344-2346 | NN | denotes | RA |
T650 | 2341-2343 | IN | denotes | of |
T649 | 2329-2340 | NN | denotes | progression |
T648 | 2325-2328 | CC | denotes | and |
T647 | 2313-2324 | NN | denotes | development |
T646 | 2309-2312 | DT | denotes | the |
T645 | 2306-2308 | IN | denotes | in |
T644 | 2300-2305 | NN | denotes | NF-κB |
T643 | 2297-2299 | IN | denotes | of |
T642 | 2292-2296 | NN | denotes | role |
T641 | 2285-2291 | JJ | denotes | active |
T640 | 2281-2284 | DT | denotes | the |
T639 | 2269-2280 | VB | denotes | demonstrate |
T638 | 2264-2268 | RB | denotes | also |
T637 | 2254-2263 | NN | denotes | arthritis |
T636 | 2241-2253 | JJ | denotes | inflammatory |
T635 | 2238-2240 | IN | denotes | of |
T634 | 2231-2237 | NN | denotes | models |
T633 | 2224-2230 | NN | denotes | animal |
T632 | 2220-2223 | CC | denotes | and |
T631 | 2218-2219 | -COMMA- | denotes | , |
T630 | 2210-2218 | NN | denotes | patients |
T629 | 2207-2209 | NN | denotes | RA |
T628 | 2202-2206 | IN | denotes | from |
T627 | 2195-2201 | NN | denotes | tissue |
T626 | 2186-2194 | JJ | denotes | synovial |
T625 | 2182-2185 | CC | denotes | and |
T624 | 2170-2181 | NN | denotes | fibroblasts |
T623 | 2161-2169 | JJ | denotes | synovial |
T622 | 2152-2160 | VB | denotes | cultured |
T621 | 2149-2151 | IN | denotes | in |
T620 | 2140-2148 | VB | denotes | detected |
T619 | 2137-2139 | VB | denotes | be |
T618 | 2133-2136 | MD | denotes | can |
T617 | 2122-2132 | NN | denotes | activation |
T616 | 2116-2121 | NN | denotes | NF-κB |
T615 | 2113-2114 | -RRB- | denotes | ) |
T614 | 2112-2113 | -RRB- | denotes | ] |
T613 | 2109-2112 | CD | denotes | 2,3 |
T612 | 2108-2109 | -LRB- | denotes | [ |
T611 | 2105-2107 | IN | denotes | in |
T610 | 2096-2104 | VB | denotes | reviewed |
T609 | 2095-2096 | -LRB- | denotes | ( |
T608 | 2089-2094 | NN | denotes | NF-κB |
T607 | 2086-2088 | IN | denotes | of |
T606 | 2075-2085 | NN | denotes | activators |
T605 | 2068-2074 | JJ | denotes | potent |
T604 | 2063-2067 | RB | denotes | very |
T603 | 2052-2062 | PRP | denotes | themselves |
T602 | 2048-2051 | VB | denotes | are |
T601 | 2043-2047 | NN | denotes | IL-1 |
T600 | 2039-2042 | CC | denotes | and |
T599 | 2035-2038 | NN | denotes | TNF |
T598 | 2033-2034 | -COMMA- | denotes | , |
T597 | 2025-2033 | NN | denotes | addition |
T596 | 2022-2024 | IN | denotes | In |
T595 | 2018-2020 | NN | denotes | RA |
T594 | 2015-2017 | IN | denotes | in |
T593 | 2006-2014 | VB | denotes | involved |
T592 | 2002-2005 | VB | denotes | are |
T591 | 1997-2001 | WDT | denotes | that |
T590 | 1995-1996 | -COLON- | denotes | - |
T589 | 1976-1994 | NN | denotes | metalloproteinases |
T588 | 1969-1975 | NN | denotes | matrix |
T587 | 1965-1968 | CC | denotes | and |
T586 | 1963-1964 | -COMMA- | denotes | , |
T585 | 1955-1963 | NN | denotes | synthase |
T584 | 1949-1954 | NN | denotes | oxide |
T583 | 1942-1948 | JJ | denotes | nitric |
T582 | 1932-1941 | JJ | denotes | inducible |
T581 | 1930-1931 | -COMMA- | denotes | , |
T580 | 1920-1930 | NN | denotes | chemokines |
T579 | 1918-1919 | -COMMA- | denotes | , |
T578 | 1901-1918 | NN | denotes | cyclo-oxygenase-2 |
T577 | 1899-1900 | -COMMA- | denotes | , |
T576 | 1895-1899 | NN | denotes | IL-6 |
T575 | 1893-1894 | -COMMA- | denotes | , |
T574 | 1889-1893 | NN | denotes | IL-1 |
T573 | 1887-1888 | -COMMA- | denotes | , |
T572 | 1884-1887 | NN | denotes | TNF |
T571 | 1881-1883 | IN | denotes | as |
T570 | 1876-1880 | JJ | denotes | such |
T569 | 1874-1875 | -COLON- | denotes | - |
T568 | 1868-1873 | NN | denotes | genes |
T567 | 1865-1867 | IN | denotes | of |
T566 | 1858-1864 | NN | denotes | number |
T565 | 1852-1857 | JJ | denotes | large |
T564 | 1850-1851 | DT | denotes | a |
T563 | 1847-1849 | IN | denotes | of |
T562 | 1836-1846 | NN | denotes | expression |
T561 | 1832-1835 | DT | denotes | the |
T560 | 1823-1831 | VB | denotes | regulate |
T559 | 1818-1822 | WDT | denotes | that |
T558 | 1814-1817 | CC | denotes | and |
T557 | 1812-1813 | -COMMA- | denotes | , |
T556 | 1811-1812 | -RRB- | denotes | ] |
T555 | 1810-1811 | CD | denotes | 1 |
T554 | 1809-1810 | -LRB- | denotes | [ |
T553 | 1796-1808 | NN | denotes | heterodimers |
T552 | 1793-1795 | CC | denotes | or |
T551 | 1782-1792 | NN | denotes | homodimers |
T550 | 1779-1781 | IN | denotes | as |
T549 | 1770-1778 | VB | denotes | function |
T548 | 1765-1769 | WDT | denotes | that |
T547 | 1763-1764 | -RRB- | denotes | ) |
T546 | 1758-1763 | NN | denotes | c-Rel |
T545 | 1756-1757 | -COMMA- | denotes | , |
T544 | 1752-1756 | NN | denotes | RelB |
T543 | 1750-1751 | -COMMA- | denotes | , |
T542 | 1746-1750 | NN | denotes | RelA |
T541 | 1743-1745 | CC | denotes | or |
T540 | 1739-1742 | NN | denotes | p65 |
T539 | 1737-1738 | -COMMA- | denotes | , |
T538 | 1731-1737 | NN | denotes | NF-κB1 |
T537 | 1728-1730 | CC | denotes | or |
T536 | 1723-1727 | NN | denotes | p105 |
T535 | 1721-1722 | -COMMA- | denotes | , |
T534 | 1715-1721 | NN | denotes | NF-κB2 |
T533 | 1712-1714 | CC | denotes | or |
T532 | 1707-1711 | NN | denotes | p100 |
T531 | 1706-1707 | -LRB- | denotes | ( |
T530 | 1697-1705 | NN | denotes | proteins |
T529 | 1687-1696 | VB | denotes | conserved |
T528 | 1672-1686 | RB | denotes | evolutionarily |
T527 | 1668-1671 | CC | denotes | and |
T526 | 1660-1667 | VB | denotes | related |
T525 | 1647-1659 | RB | denotes | structurally |
T524 | 1644-1646 | IN | denotes | of |
T523 | 1637-1643 | NN | denotes | family |
T522 | 1635-1636 | DT | denotes | a |
T521 | 1624-1634 | VB | denotes | represents |
T520 | 1618-1623 | NN | denotes | NF-κB |
T519 | 1608-1616 | NN | denotes | diseases |
T518 | 1597-1607 | JJ | denotes | autoimmune |
T517 | 1591-1596 | JJ | denotes | other |
T516 | 1586-1590 | JJ | denotes | many |
T515 | 1582-1585 | CC | denotes | and |
T514 | 1579-1581 | NN | denotes | RA |
T513 | 1576-1578 | IN | denotes | of |
T512 | 1564-1575 | NN | denotes | development |
T511 | 1560-1563 | DT | denotes | the |
T510 | 1557-1559 | IN | denotes | in |
T509 | 1552-1556 | NN | denotes | role |
T508 | 1548-1551 | JJ | denotes | key |
T507 | 1546-1547 | DT | denotes | a |
T506 | 1540-1545 | VB | denotes | plays |
T505 | 1529-1539 | NN | denotes | expression |
T504 | 1524-1528 | NN | denotes | gene |
T503 | 1508-1523 | JJ | denotes | NF-κB-dependent |
T502 | 1505-1507 | IN | denotes | of |
T501 | 1494-1504 | NN | denotes | activation |
T500 | 1489-1493 | IN | denotes | that |
T499 | 1480-1488 | VB | denotes | accepted |
T498 | 1475-1479 | RB | denotes | well |
T497 | 1472-1474 | VB | denotes | is |
T496 | 1469-1471 | PRP | denotes | it |
T495 | 1465-1468 | CC | denotes | but |
T494 | 1463-1464 | -COMMA- | denotes | , |
T493 | 1453-1463 | VB | denotes | understood |
T492 | 1449-1452 | RB | denotes | not |
T491 | 1443-1448 | RB | denotes | still |
T490 | 1440-1442 | VB | denotes | is |
T489 | 1437-1439 | NN | denotes | RA |
T488 | 1434-1436 | IN | denotes | of |
T487 | 1424-1433 | NN | denotes | aetiology |
T486 | 1420-1423 | DT | denotes | The |
T485 | 1414-1418 | NN | denotes | bone |
T484 | 1402-1413 | JJ | denotes | subchondral |
T483 | 1398-1401 | CC | denotes | and |
T482 | 1388-1397 | NN | denotes | cartilage |
T481 | 1378-1387 | JJ | denotes | articular |
T480 | 1369-1377 | VB | denotes | degrades |
T479 | 1365-1368 | CC | denotes | and |
T478 | 1357-1364 | VB | denotes | invades |
T477 | 1351-1356 | WDT | denotes | which |
T476 | 1349-1350 | -COMMA- | denotes | , |
T475 | 1343-1349 | NN | denotes | tissue |
T474 | 1336-1342 | NN | denotes | pannus |
T473 | 1333-1335 | IN | denotes | of |
T472 | 1323-1332 | NN | denotes | formation |
T471 | 1319-1322 | DT | denotes | the |
T470 | 1316-1318 | TO | denotes | to |
T469 | 1310-1315 | VB | denotes | leads |
T468 | 1298-1309 | NN | denotes | fibroblasts |
T467 | 1289-1297 | JJ | denotes | synovial |
T466 | 1286-1288 | IN | denotes | of |
T465 | 1272-1285 | NN | denotes | Proliferation |
T464 | 1265-1270 | NN | denotes | cells |
T463 | 1256-1264 | JJ | denotes | synovial |
T462 | 1252-1255 | CC | denotes | and |
T461 | 1242-1251 | NN | denotes | monocytes |
T460 | 1229-1241 | VB | denotes | infiltrating |
T459 | 1226-1228 | IN | denotes | by |
T458 | 1207-1225 | NN | denotes | metalloproteinases |
T457 | 1200-1206 | NN | denotes | matrix |
T456 | 1196-1199 | CC | denotes | and |
T455 | 1194-1195 | -COMMA- | denotes | , |
T454 | 1184-1194 | NN | denotes | chemokines |
T453 | 1182-1183 | -COMMA- | denotes | , |
T440 | 1096-1099 | DT | denotes | the |
T439 | 1089-1095 | VB | denotes | drives |
T438 | 1083-1088 | NN | denotes | space |
T437 | 1077-1082 | JJ | denotes | joint |
T436 | 1073-1076 | DT | denotes | the |
T435 | 1068-1072 | IN | denotes | into |
T434 | 1061-1067 | NN | denotes | system |
T433 | 1054-1060 | JJ | denotes | immune |
T432 | 1045-1053 | JJ | denotes | adaptive |
T431 | 1041-1044 | CC | denotes | and |
T430 | 1034-1040 | JJ | denotes | innate |
T429 | 1030-1033 | DT | denotes | the |
T428 | 1027-1029 | IN | denotes | of |
T427 | 1021-1026 | NN | denotes | cells |
T426 | 1018-1020 | IN | denotes | of |
T425 | 1005-1017 | NN | denotes | Infiltration |
T424 | 993-1003 | NN | denotes | disability |
T423 | 989-992 | CC | denotes | and |
T422 | 981-988 | NN | denotes | decline |
T421 | 970-980 | JJ | denotes | functional |
T692 | 2554-2558 | NN | denotes | gene |
T691 | 2538-2553 | JJ | denotes | proinflammatory |
T690 | 2535-2537 | IN | denotes | in |
T689 | 2530-2534 | NN | denotes | role |
T688 | 2526-2529 | PRP-DOLLAR- | denotes | its |
T687 | 2523-2525 | TO | denotes | to |
T686 | 2518-2522 | JJ | denotes | Next |
T685 | 2515-2516 | -RRB- | denotes | ] |
T684 | 2512-2515 | CD | denotes | 5,6 |
T683 | 2511-2512 | -LRB- | denotes | [ |
T682 | 2502-2510 | NN | denotes | severity |
T681 | 2494-2501 | NN | denotes | disease |
T680 | 2484-2493 | VB | denotes | decreases |
T679 | 2478-2483 | NN | denotes | means |
T678 | 2468-2477 | JJ | denotes | different |
T677 | 2465-2467 | IN | denotes | by |
T676 | 2459-2464 | NN | denotes | NF-κB |
T675 | 2456-2458 | IN | denotes | of |
T674 | 2447-2455 | NN | denotes | blockade |
T673 | 2443-2446 | CC | denotes | and |
T672 | 2441-2442 | -COMMA- | denotes | , |
T671 | 2434-2441 | NN | denotes | disease |
T670 | 2431-2433 | IN | denotes | of |
T669 | 2425-2430 | NN | denotes | onset |
T44 | 284-285 | -COMMA- | denotes | , |
T43 | 276-284 | NN | denotes | diseases |
T42 | 263-275 | JJ | denotes | inflammatory |
T41 | 259-262 | CC | denotes | and |
T40 | 248-258 | JJ | denotes | autoimmune |
T39 | 243-247 | JJ | denotes | many |
T38 | 238-242 | IN | denotes | with |
T37 | 231-237 | VB | denotes | linked |
T36 | 226-230 | VB | denotes | been |
T35 | 222-225 | VB | denotes | has |
T34 | 213-221 | NN | denotes | activity |
T33 | 207-212 | NN | denotes | NF-κB |
T32 | 193-206 | JJ | denotes | inappropriate |
T31 | 189-192 | CC | denotes | and |
T30 | 187-188 | -COMMA- | denotes | , |
T29 | 178-187 | NN | denotes | responses |
T28 | 172-177 | JJ | denotes | mmune |
T27 | 168-171 | CC | denotes | and |
T26 | 155-167 | NN | denotes | inflammation |
T25 | 152-154 | IN | denotes | of |
T24 | 141-151 | NN | denotes | regulation |
T23 | 137-140 | DT | denotes | the |
T22 | 134-136 | IN | denotes | in |
T21 | 128-133 | NN | denotes | roles |
T20 | 120-127 | JJ | denotes | crucial |
T19 | 114-119 | VB | denotes | plays |
T18 | 108-113 | NN | denotes | NF-κB |
T17 | 101-107 | NN | denotes | factor |
T16 | 87-100 | NN | denotes | transcription |
T15 | 83-86 | DT | denotes | The |
T452 | 1173-1182 | NN | denotes | cytokines |
T451 | 1170-1172 | CD | denotes | 17 |
T450 | 1165-1169 | NN | denotes | type |
T449 | 1156-1164 | NN | denotes | T-helper |
T448 | 1152-1155 | CC | denotes | and |
T447 | 1150-1151 | CD | denotes | 1 |
T446 | 1145-1149 | NN | denotes | type |
T445 | 1136-1144 | NN | denotes | T-helper |
T444 | 1120-1135 | JJ | denotes | proinflammatory |
T443 | 1117-1119 | IN | denotes | of |
T442 | 1106-1116 | NN | denotes | production |
T441 | 1100-1105 | JJ | denotes | local |
T98 | 662-671 | NN | denotes | arthritis |
T97 | 651-661 | JJ | denotes | rheumatoid |
T96 | 648-650 | IN | denotes | of |
T95 | 635-647 | NN | denotes | pathogenesis |
T94 | 631-634 | DT | denotes | the |
T93 | 628-630 | IN | denotes | in |
T92 | 617-627 | VB | denotes | implicated |
T91 | 612-616 | VB | denotes | been |
T90 | 607-611 | VB | denotes | have |
T89 | 601-606 | WDT | denotes | which |
T88 | 597-600 | CC | denotes | and |
T87 | 586-596 | NN | denotes | signalling |
T86 | 580-585 | NN | denotes | NF-κB |
T85 | 572-579 | VB | denotes | control |
T84 | 569-571 | TO | denotes | to |
T83 | 561-568 | VB | denotes | evolved |
T82 | 556-560 | VB | denotes | have |
T81 | 551-555 | WDT | denotes | that |
T80 | 540-550 | NN | denotes | mechanisms |
T79 | 529-539 | JJ | denotes | regulatory |
T78 | 520-528 | JJ | denotes | negative |
T77 | 512-519 | JJ | denotes | various |
T76 | 505-511 | VB | denotes | review |
T75 | 500-504 | MD | denotes | will |
T74 | 497-499 | PRP | denotes | we |
T73 | 492-496 | RB | denotes | Here |
T72 | 481-490 | NN | denotes | responses |
T71 | 475-480 | NN | denotes | NF-κB |
T70 | 472-474 | IN | denotes | of |
T69 | 460-471 | NN | denotes | termination |
T68 | 451-459 | VB | denotes | ensuring |
T67 | 440-450 | NN | denotes | regulators |
T66 | 431-439 | NN | denotes | feedback |
T65 | 422-430 | JJ | denotes | negative |
T64 | 419-421 | IN | denotes | of |
T63 | 408-418 | NN | denotes | repertoire |
T62 | 406-407 | DT | denotes | a |
T61 | 396-405 | VB | denotes | including |
T60 | 394-395 | -COMMA- | denotes | , |
T59 | 389-394 | NN | denotes | check |
T58 | 386-388 | IN | denotes | in |
T57 | 375-385 | NN | denotes | signalling |
T56 | 369-374 | NN | denotes | NF-κB |
T55 | 364-368 | VB | denotes | keep |
T54 | 361-363 | TO | denotes | to |
T53 | 354-360 | NN | denotes | system |
T52 | 346-353 | NN | denotes | control |
T51 | 333-345 | JJ | denotes | multilayered |
T50 | 331-332 | DT | denotes | a |
T49 | 324-330 | VB | denotes | employ |
T48 | 318-323 | NN | denotes | Cells |
T47 | 307-316 | NN | denotes | arthritis |
T46 | 296-306 | JJ | denotes | rheumatoid |
T45 | 286-295 | VB | denotes | including |
T390 | 773-774 | NN | denotes | % |
T389 | 772-773 | CD | denotes | 1 |
T388 | 769-771 | TO | denotes | to |
T387 | 766-768 | IN | denotes | up |
T386 | 756-765 | VB | denotes | affecting |
T385 | 754-755 | -COMMA- | denotes | , |
T384 | 745-754 | NN | denotes | arthritis |
T383 | 732-744 | JJ | denotes | inflammatory |
T420 | 967-969 | TO | denotes | to |
T419 | 959-966 | VB | denotes | leading |
T418 | 957-958 | -COMMA- | denotes | , |
T417 | 953-957 | NN | denotes | bone |
T416 | 949-952 | CC | denotes | and |
T415 | 939-948 | NN | denotes | cartilage |
T414 | 936-938 | IN | denotes | of |
T413 | 924-935 | NN | denotes | destruction |
T412 | 912-923 | JJ | denotes | progressive |
T411 | 910-911 | DT | denotes | a |
T410 | 905-909 | IN | denotes | with |
T409 | 894-904 | VB | denotes | associated |
T408 | 891-893 | VB | denotes | is |
T407 | 884-890 | NN | denotes | joints |
T406 | 881-883 | IN | denotes | of |
T405 | 868-880 | NN | denotes | inflammation |
T404 | 860-867 | JJ | denotes | chronic |
T403 | 854-859 | WDT | denotes | which |
T402 | 851-853 | IN | denotes | in |
T401 | 837-850 | NN | denotes | polyarthritis |
T400 | 825-836 | JJ | denotes | symmetrical |
T399 | 823-824 | DT | denotes | a |
T398 | 820-822 | IN | denotes | by |
T397 | 806-819 | VB | denotes | characterised |
T396 | 803-805 | VB | denotes | is |
T395 | 800-802 | NN | denotes | RA |
T394 | 788-798 | NN | denotes | population |
T393 | 782-787 | JJ | denotes | adult |
T392 | 778-781 | DT | denotes | the |
T391 | 775-777 | IN | denotes | of |
T382 | 725-731 | JJ | denotes | common |
T381 | 720-724 | RB | denotes | most |
T380 | 716-719 | DT | denotes | the |
T379 | 713-715 | VB | denotes | is |
T378 | 711-712 | -RRB- | denotes | ) |
T377 | 709-711 | NN | denotes | RA |
T376 | 708-709 | -LRB- | denotes | ( |
T375 | 698-707 | NN | denotes | arthritis |
T374 | 687-697 | JJ | denotes | Rheumatoid |
T15548 | 27358-27362 | NN | denotes | IL-1 |
T19037 | 33648-33650 | NN | denotes | RA |
T19036 | 33645-33647 | IN | denotes | as |
T19035 | 33640-33644 | JJ | denotes | such |
T19034 | 33631-33639 | NN | denotes | diseases |
R1933 | T2438 | T2437 | arg1Of | pathology,RA |
R1934 | T2442 | T2440 | arg1Of | components,extracellular |
R1935 | T2442 | T2441 | arg1Of | components,matrix |
R3886 | T5372 | T5374 | arg1Of | and,mediate |
R3887 | T5431 | T5429 | arg2Of | activation,in |
R3888 | T5431 | T5430 | arg1Of | activation,the |
R3889 | T5431 | T5432 | arg1Of | activation,of |
R3890 | T5435 | T5432 | arg2Of | pathway,of |
R5839 | T8669 | T8668 | arg1Of | degradation,IκBα |
R5840 | T8671 | T8670 | arg2Of | 34,[ |
R5841 | T8672 | T8670 | arg3Of | ],[ |
R7225 | T10620 | T10619 | arg1Of | tools,valuable |
R9626 | T14515 | T14516 | arg1Of | it,is |
R9627 | T14515 | T14517 | arg1Of | it,worth |
R9628 | T14516 | T14511 | arg1Of | is,In |
R11003 | T16656 | T16657 | arg1Of | work,in |
R11004 | T16656 | T16662 | arg1Of | work,demonstrates |
R11005 | T16660 | T16657 | arg2Of | population,in |
R11006 | T16660 | T16658 | arg1Of | population,a |
R13240 | T19944 | T19943 | arg1Of | kinase,IL-1R-associated |
R13241 | T19946 | T19947 | arg1Of | MyD88,"," |
R14175 | T21693 | T21691 | arg1Of | regulator,a |
R14176 | T21693 | T21692 | arg1Of | regulator,negative |
R14177 | T21693 | T21694 | arg1Of | regulator,of |
R1 | T6 | T5 | arg1Of | regulation,Negative |
R2 | T6 | T7 | arg1Of | regulation,of |
R3 | T6 | T9 | arg1Of | regulation,and |
R4 | T8 | T7 | arg2Of | NF-κB,of |
R5 | T11 | T9 | arg2Of | involvement,and |
R6 | T11 | T10 | arg1Of | involvement,its |
R7 | T11 | T12 | arg1Of | involvement,in |
R8 | T14 | T12 | arg2Of | arthritis,in |
R9 | T14 | T13 | arg1Of | arthritis,rheumatoid |
R10 | T18 | T15 | arg1Of | NF-κB,The |
R11 | T18 | T16 | arg1Of | NF-κB,transcription |
R12 | T18 | T17 | arg1Of | NF-κB,factor |
R13 | T18 | T19 | arg1Of | NF-κB,plays |
R14 | T19 | T22 | arg1Of | plays,in |
R15 | T19 | T31 | arg1Of | plays,and |
R16 | T21 | T19 | arg2Of | roles,plays |
R17 | T21 | T20 | arg1Of | roles,crucial |
R18 | T24 | T22 | arg2Of | regulation,in |
R19 | T24 | T23 | arg1Of | regulation,the |
R20 | T24 | T25 | arg1Of | regulation,of |
R21 | T26 | T27 | arg1Of | inflammation,and |
R22 | T27 | T25 | arg2Of | and,of |
R23 | T29 | T27 | arg2Of | responses,and |
R24 | T29 | T28 | arg1Of | responses,mmune |
R25 | T31 | T30 | arg1Of | and,"," |
R26 | T34 | T32 | arg1Of | activity,inappropriate |
R27 | T34 | T33 | arg1Of | activity,NF-κB |
R28 | T34 | T35 | arg1Of | activity,has |
R29 | T34 | T36 | arg1Of | activity,been |
R30 | T34 | T37 | arg2Of | activity,linked |
R31 | T37 | T31 | arg2Of | linked,and |
R32 | T37 | T35 | arg2Of | linked,has |
R33 | T37 | T36 | arg2Of | linked,been |
R34 | T37 | T38 | arg1Of | linked,with |
R35 | T40 | T41 | arg1Of | autoimmune,and |
R36 | T42 | T41 | arg2Of | inflammatory,and |
R37 | T43 | T38 | arg2Of | diseases,with |
R38 | T43 | T39 | arg1Of | diseases,many |
R39 | T43 | T40 | arg1Of | diseases,autoimmune |
R40 | T43 | T42 | arg1Of | diseases,inflammatory |
R41 | T43 | T44 | arg1Of | diseases,"," |
R42 | T43 | T45 | arg1Of | diseases,including |
R43 | T47 | T45 | arg2Of | arthritis,including |
R44 | T47 | T46 | arg1Of | arthritis,rheumatoid |
R45 | T48 | T49 | arg1Of | Cells,employ |
R46 | T49 | T54 | modOf | employ,to |
R47 | T53 | T49 | arg2Of | system,employ |
R48 | T53 | T50 | arg1Of | system,a |
R49 | T53 | T51 | arg1Of | system,multilayered |
R50 | T53 | T52 | arg1Of | system,control |
R51 | T55 | T54 | arg1Of | keep,to |
R52 | T55 | T58 | arg1Of | keep,in |
R53 | T57 | T55 | arg2Of | signalling,keep |
R54 | T57 | T56 | arg1Of | signalling,NF-κB |
R55 | T59 | T58 | arg2Of | check,in |
R56 | T59 | T60 | arg1Of | check,"," |
R57 | T59 | T61 | arg1Of | check,including |
R58 | T63 | T61 | arg2Of | repertoire,including |
R59 | T63 | T62 | arg1Of | repertoire,a |
R60 | T63 | T64 | arg1Of | repertoire,of |
R61 | T67 | T64 | arg2Of | regulators,of |
R62 | T67 | T65 | arg1Of | regulators,negative |
R63 | T67 | T66 | arg1Of | regulators,feedback |
R64 | T67 | T68 | arg1Of | regulators,ensuring |
R65 | T69 | T68 | arg2Of | termination,ensuring |
R66 | T69 | T70 | arg1Of | termination,of |
R67 | T72 | T70 | arg2Of | responses,of |
R68 | T72 | T71 | arg1Of | responses,NF-κB |
R69 | T74 | T75 | arg1Of | we,will |
R70 | T74 | T76 | arg1Of | we,review |
R71 | T76 | T73 | arg1Of | review,Here |
R72 | T76 | T75 | arg2Of | review,will |
R73 | T80 | T76 | arg2Of | mechanisms,review |
R74 | T80 | T77 | arg1Of | mechanisms,various |
R75 | T80 | T78 | arg1Of | mechanisms,negative |
R76 | T80 | T79 | arg1Of | mechanisms,regulatory |
R77 | T80 | T81 | arg1Of | mechanisms,that |
R78 | T80 | T82 | arg1Of | mechanisms,have |
R79 | T80 | T83 | arg1Of | mechanisms,evolved |
R80 | T80 | T85 | arg1Of | mechanisms,control |
R81 | T80 | T89 | arg1Of | mechanisms,which |
R82 | T80 | T90 | arg1Of | mechanisms,have |
R83 | T80 | T91 | arg1Of | mechanisms,been |
R84 | T80 | T92 | arg2Of | mechanisms,implicated |
R85 | T83 | T82 | arg2Of | evolved,have |
R86 | T83 | T88 | arg1Of | evolved,and |
R87 | T85 | T83 | arg2Of | control,evolved |
R88 | T85 | T84 | arg1Of | control,to |
R89 | T87 | T85 | arg2Of | signalling,control |
R90 | T87 | T86 | arg1Of | signalling,NF-κB |
R91 | T92 | T88 | arg2Of | implicated,and |
R92 | T92 | T90 | arg2Of | implicated,have |
R93 | T92 | T91 | arg2Of | implicated,been |
R94 | T92 | T93 | arg1Of | implicated,in |
R95 | T95 | T93 | arg2Of | pathogenesis,in |
R96 | T95 | T94 | arg1Of | pathogenesis,the |
R97 | T95 | T96 | arg1Of | pathogenesis,of |
R98 | T98 | T96 | arg2Of | arthritis,of |
R99 | T98 | T97 | arg1Of | arthritis,rheumatoid |
R243 | T384 | T380 | arg1Of | arthritis,the |
R244 | T384 | T382 | arg1Of | arthritis,common |
R245 | T384 | T383 | arg1Of | arthritis,inflammatory |
R246 | T389 | T387 | arg1Of | 1,up |
R247 | T389 | T388 | arg1Of | 1,to |
R248 | T390 | T386 | arg2Of | %,affecting |
R249 | T390 | T389 | arg1Of | %,1 |
R250 | T390 | T391 | arg1Of | %,of |
R251 | T394 | T391 | arg2Of | population,of |
R252 | T394 | T392 | arg1Of | population,the |
R253 | T394 | T393 | arg1Of | population,adult |
R254 | T395 | T396 | arg1Of | RA,is |
R255 | T395 | T397 | arg2Of | RA,characterised |
R256 | T397 | T396 | arg2Of | characterised,is |
R257 | T401 | T397 | arg1Of | polyarthritis,characterised |
R258 | T401 | T398 | arg2Of | polyarthritis,by |
R259 | T401 | T399 | arg1Of | polyarthritis,a |
R260 | T401 | T400 | arg1Of | polyarthritis,symmetrical |
R261 | T401 | T402 | arg2Of | polyarthritis,in |
R262 | T401 | T403 | arg1Of | polyarthritis,which |
R263 | T405 | T404 | arg1Of | inflammation,chronic |
R264 | T405 | T406 | arg1Of | inflammation,of |
R265 | T405 | T408 | arg1Of | inflammation,is |
R266 | T405 | T409 | arg2Of | inflammation,associated |
R267 | T407 | T406 | arg2Of | joints,of |
R268 | T409 | T402 | arg1Of | associated,in |
R269 | T409 | T408 | arg2Of | associated,is |
R270 | T409 | T410 | arg1Of | associated,with |
R271 | T409 | T418 | arg1Of | associated,"," |
R272 | T409 | T419 | modOf | associated,leading |
R273 | T413 | T410 | arg2Of | destruction,with |
R274 | T413 | T411 | arg1Of | destruction,a |
R275 | T413 | T412 | arg1Of | destruction,progressive |
R276 | T413 | T414 | arg1Of | destruction,of |
R277 | T415 | T416 | arg1Of | cartilage,and |
R278 | T416 | T414 | arg2Of | and,of |
R279 | T417 | T416 | arg2Of | bone,and |
R280 | T419 | T420 | arg1Of | leading,to |
R281 | T422 | T423 | arg1Of | decline,and |
R282 | T423 | T420 | arg2Of | and,to |
R283 | T423 | T421 | arg1Of | and,functional |
R284 | T424 | T423 | arg2Of | disability,and |
R285 | T425 | T426 | arg1Of | Infiltration,of |
R286 | T425 | T435 | arg1Of | Infiltration,into |
R287 | T425 | T439 | arg1Of | Infiltration,drives |
R288 | T425 | T460 | arg1Of | Infiltration,infiltrating |
R289 | T427 | T426 | arg2Of | cells,of |
R290 | T427 | T428 | arg1Of | cells,of |
R291 | T430 | T431 | arg1Of | innate,and |
R292 | T432 | T431 | arg2Of | adaptive,and |
R293 | T434 | T428 | arg2Of | system,of |
R294 | T434 | T429 | arg1Of | system,the |
R295 | T434 | T430 | arg1Of | system,innate |
R296 | T434 | T432 | arg1Of | system,adaptive |
R297 | T434 | T433 | arg1Of | system,immune |
R298 | T438 | T435 | arg2Of | space,into |
R299 | T438 | T436 | arg1Of | space,the |
R300 | T438 | T437 | arg1Of | space,joint |
R301 | T439 | T459 | arg1Of | drives,by |
R302 | T442 | T439 | arg2Of | production,drives |
R303 | T442 | T440 | arg1Of | production,the |
R304 | T442 | T441 | arg1Of | production,local |
R305 | T442 | T443 | arg1Of | production,of |
R306 | T447 | T448 | arg1Of | 1,and |
R307 | T449 | T448 | arg2Of | T-helper,and |
R308 | T452 | T444 | arg1Of | cytokines,proinflammatory |
R309 | T452 | T445 | arg1Of | cytokines,T-helper |
R310 | T452 | T446 | arg1Of | cytokines,type |
R311 | T452 | T447 | arg1Of | cytokines,1 |
R312 | T452 | T449 | arg1Of | cytokines,T-helper |
R313 | T452 | T450 | arg1Of | cytokines,type |
R314 | T452 | T451 | arg1Of | cytokines,17 |
R315 | T452 | T453 | arg1Of | cytokines,"," |
R316 | T453 | T456 | arg1Of | ",",and |
R317 | T454 | T453 | arg2Of | chemokines,"," |
R318 | T456 | T443 | arg2Of | and,of |
R319 | T456 | T455 | arg1Of | and,"," |
R320 | T458 | T456 | arg2Of | metalloproteinases,and |
R321 | T458 | T457 | arg1Of | metalloproteinases,matrix |
R322 | T460 | T459 | arg2Of | infiltrating,by |
R323 | T461 | T462 | arg1Of | monocytes,and |
R324 | T462 | T460 | arg2Of | and,infiltrating |
R325 | T464 | T462 | arg2Of | cells,and |
R326 | T464 | T463 | arg1Of | cells,synovial |
R327 | T465 | T466 | arg1Of | Proliferation,of |
R328 | T465 | T469 | arg1Of | Proliferation,leads |
R329 | T468 | T466 | arg2Of | fibroblasts,of |
R330 | T468 | T467 | arg1Of | fibroblasts,synovial |
R331 | T469 | T470 | arg1Of | leads,to |
R332 | T472 | T470 | arg2Of | formation,to |
R333 | T472 | T471 | arg1Of | formation,the |
R334 | T472 | T473 | arg1Of | formation,of |
R335 | T475 | T473 | arg2Of | tissue,of |
R336 | T475 | T474 | arg1Of | tissue,pannus |
R337 | T475 | T476 | arg1Of | tissue,"," |
R338 | T475 | T477 | arg1Of | tissue,which |
R339 | T475 | T478 | arg1Of | tissue,invades |
R340 | T475 | T480 | arg1Of | tissue,degrades |
R341 | T478 | T479 | arg1Of | invades,and |
R342 | T480 | T479 | arg2Of | degrades,and |
R343 | T482 | T481 | arg1Of | cartilage,articular |
R344 | T482 | T483 | arg1Of | cartilage,and |
R345 | T483 | T478 | arg2Of | and,invades |
R346 | T483 | T480 | arg2Of | and,degrades |
R347 | T485 | T483 | arg2Of | bone,and |
R348 | T485 | T484 | arg1Of | bone,subchondral |
R349 | T487 | T486 | arg1Of | aetiology,The |
R350 | T487 | T488 | arg1Of | aetiology,of |
R351 | T487 | T490 | arg1Of | aetiology,is |
R352 | T487 | T493 | arg2Of | aetiology,understood |
R353 | T489 | T488 | arg2Of | RA,of |
R354 | T493 | T490 | arg2Of | understood,is |
R355 | T493 | T491 | arg1Of | understood,still |
R356 | T493 | T492 | arg1Of | understood,not |
R357 | T493 | T495 | arg1Of | understood,but |
R358 | T495 | T494 | arg1Of | but,"," |
R359 | T496 | T497 | arg1Of | it,is |
R360 | T496 | T499 | arg2Of | it,accepted |
R361 | T499 | T495 | arg2Of | accepted,but |
R362 | T499 | T497 | arg2Of | accepted,is |
R363 | T499 | T498 | arg1Of | accepted,well |
R364 | T501 | T502 | arg1Of | activation,of |
R365 | T501 | T506 | arg1Of | activation,plays |
R366 | T505 | T502 | arg2Of | expression,of |
R367 | T505 | T503 | arg1Of | expression,NF-κB-dependent |
R368 | T505 | T504 | arg1Of | expression,gene |
R369 | T506 | T499 | arg3Of | plays,accepted |
R370 | T506 | T500 | arg1Of | plays,that |
R371 | T506 | T510 | arg1Of | plays,in |
R372 | T509 | T506 | arg2Of | role,plays |
R373 | T509 | T507 | arg1Of | role,a |
R374 | T509 | T508 | arg1Of | role,key |
R375 | T512 | T510 | arg2Of | development,in |
R376 | T512 | T511 | arg1Of | development,the |
R377 | T512 | T513 | arg1Of | development,of |
R378 | T514 | T515 | arg1Of | RA,and |
R379 | T515 | T513 | arg2Of | and,of |
R380 | T519 | T515 | arg2Of | diseases,and |
R381 | T519 | T516 | arg1Of | diseases,many |
R382 | T519 | T517 | arg1Of | diseases,other |
R383 | T519 | T518 | arg1Of | diseases,autoimmune |
R384 | T520 | T521 | arg1Of | NF-κB,represents |
R385 | T523 | T521 | arg2Of | family,represents |
R386 | T523 | T522 | arg1Of | family,a |
R387 | T523 | T524 | arg1Of | family,of |
R388 | T523 | T569 | arg1Of | family,- |
R389 | T523 | T571 | arg1Of | family,as |
R390 | T526 | T525 | arg1Of | related,structurally |
R391 | T526 | T527 | arg1Of | related,and |
R392 | T529 | T527 | arg2Of | conserved,and |
R393 | T529 | T528 | arg1Of | conserved,evolutionarily |
R394 | T530 | T524 | arg2Of | proteins,of |
R395 | T530 | T526 | arg1Of | proteins,related |
R396 | T530 | T529 | arg1Of | proteins,conserved |
R397 | T530 | T531 | arg1Of | proteins,( |
R398 | T530 | T548 | arg1Of | proteins,that |
R399 | T530 | T549 | arg1Of | proteins,function |
R400 | T530 | T559 | arg1Of | proteins,that |
R401 | T530 | T560 | arg1Of | proteins,regulate |
R402 | T532 | T533 | arg1Of | p100,or |
R403 | T533 | T535 | arg1Of | or,"," |
R404 | T534 | T533 | arg2Of | NF-κB2,or |
R405 | T535 | T539 | arg1Of | ",","," |
R406 | T536 | T537 | arg1Of | p105,or |
R407 | T537 | T535 | arg2Of | or,"," |
R408 | T538 | T537 | arg2Of | NF-κB1,or |
R409 | T539 | T541 | arg1Of | ",",or |
R410 | T540 | T539 | arg2Of | p65,"," |
R411 | T541 | T531 | arg2Of | or,( |
R412 | T542 | T541 | arg2Of | RelA,or |
R413 | T542 | T543 | arg1Of | RelA,"," |
R414 | T542 | T545 | arg1Of | RelA,"," |
R415 | T544 | T543 | arg2Of | RelB,"," |
R416 | T546 | T545 | arg2Of | c-Rel,"," |
R417 | T547 | T531 | arg3Of | ),( |
R418 | T549 | T550 | arg1Of | function,as |
R419 | T549 | T558 | arg1Of | function,and |
R420 | T551 | T552 | arg1Of | homodimers,or |
R421 | T552 | T550 | arg2Of | or,as |
R422 | T552 | T554 | arg1Of | or,[ |
R423 | T553 | T552 | arg2Of | heterodimers,or |
R424 | T555 | T554 | arg2Of | 1,[ |
R425 | T556 | T554 | arg3Of | ],[ |
R426 | T558 | T557 | arg1Of | and,"," |
R427 | T560 | T558 | arg2Of | regulate,and |
R428 | T562 | T560 | arg2Of | expression,regulate |
R429 | T562 | T561 | arg1Of | expression,the |
R430 | T562 | T563 | arg1Of | expression,of |
R431 | T566 | T563 | arg2Of | number,of |
R432 | T566 | T564 | arg1Of | number,a |
R433 | T566 | T565 | arg1Of | number,large |
R434 | T566 | T567 | arg1Of | number,of |
R435 | T568 | T567 | arg2Of | genes,of |
R436 | T571 | T570 | arg1Of | as,such |
R437 | T572 | T573 | arg1Of | TNF,"," |
R438 | T573 | T575 | arg1Of | ",","," |
R439 | T574 | T573 | arg2Of | IL-1,"," |
R440 | T575 | T577 | arg1Of | ",","," |
R441 | T576 | T575 | arg2Of | IL-6,"," |
R442 | T577 | T579 | arg1Of | ",","," |
R443 | T578 | T577 | arg2Of | cyclo-oxygenase-2,"," |
R444 | T579 | T581 | arg1Of | ",","," |
R445 | T580 | T579 | arg2Of | chemokines,"," |
R446 | T581 | T587 | arg1Of | ",",and |
R447 | T585 | T581 | arg2Of | synthase,"," |
R448 | T585 | T582 | arg1Of | synthase,inducible |
R449 | T585 | T583 | arg1Of | synthase,nitric |
R450 | T585 | T584 | arg1Of | synthase,oxide |
R451 | T587 | T571 | arg2Of | and,as |
R452 | T587 | T586 | arg1Of | and,"," |
R453 | T589 | T587 | arg2Of | metalloproteinases,and |
R454 | T589 | T588 | arg1Of | metalloproteinases,matrix |
R455 | T589 | T590 | arg1Of | metalloproteinases,- |
R456 | T589 | T591 | arg1Of | metalloproteinases,that |
R457 | T589 | T592 | arg1Of | metalloproteinases,are |
R458 | T589 | T593 | arg2Of | metalloproteinases,involved |
R459 | T593 | T592 | arg2Of | involved,are |
R460 | T593 | T594 | arg1Of | involved,in |
R461 | T595 | T594 | arg2Of | RA,in |
R462 | T597 | T596 | arg2Of | addition,In |
R463 | T599 | T600 | arg1Of | TNF,and |
R464 | T600 | T602 | arg1Of | and,are |
R465 | T601 | T600 | arg2Of | IL-1,and |
R466 | T602 | T596 | arg1Of | are,In |
R467 | T602 | T598 | arg1Of | are,"," |
R468 | T603 | T602 | arg2Of | themselves,are |
R469 | T603 | T606 | arg1Of | themselves,activators |
R470 | T605 | T604 | arg1Of | potent,very |
R471 | T606 | T605 | arg1Of | activators,potent |
R472 | T606 | T607 | arg1Of | activators,of |
R473 | T606 | T609 | arg1Of | activators,( |
R474 | T608 | T607 | arg2Of | NF-κB,of |
R475 | T610 | T609 | arg2Of | reviewed,( |
R476 | T610 | T611 | arg1Of | reviewed,in |
R477 | T610 | T612 | arg1Of | reviewed,[ |
R478 | T613 | T612 | arg2Of | "2,3",[ |
R479 | T614 | T612 | arg3Of | ],[ |
R480 | T615 | T609 | arg3Of | ),( |
R481 | T617 | T616 | arg1Of | activation,NF-κB |
R482 | T617 | T618 | arg1Of | activation,can |
R483 | T617 | T619 | arg1Of | activation,be |
R484 | T617 | T620 | arg2Of | activation,detected |
R485 | T620 | T618 | arg2Of | detected,can |
R486 | T620 | T619 | arg2Of | detected,be |
R487 | T620 | T621 | arg1Of | detected,in |
R488 | T620 | T632 | arg1Of | detected,and |
R489 | T624 | T622 | arg2Of | fibroblasts,cultured |
R490 | T624 | T623 | arg1Of | fibroblasts,synovial |
R491 | T624 | T625 | arg1Of | fibroblasts,and |
R492 | T625 | T621 | arg2Of | and,in |
R493 | T627 | T625 | arg2Of | tissue,and |
R494 | T627 | T626 | arg1Of | tissue,synovial |
R495 | T627 | T628 | arg1Of | tissue,from |
R496 | T630 | T628 | arg2Of | patients,from |
R497 | T630 | T629 | arg1Of | patients,RA |
R498 | T632 | T631 | arg1Of | and,"," |
R499 | T634 | T633 | arg1Of | models,animal |
R500 | T634 | T635 | arg1Of | models,of |
R501 | T634 | T639 | arg1Of | models,demonstrate |
R502 | T637 | T635 | arg2Of | arthritis,of |
R503 | T637 | T636 | arg1Of | arthritis,inflammatory |
R504 | T639 | T632 | arg2Of | demonstrate,and |
R505 | T639 | T638 | arg1Of | demonstrate,also |
R506 | T642 | T639 | arg2Of | role,demonstrate |
R507 | T642 | T640 | arg1Of | role,the |
R508 | T642 | T641 | arg1Of | role,active |
R509 | T642 | T643 | arg1Of | role,of |
R510 | T642 | T645 | arg1Of | role,in |
R511 | T642 | T652 | arg1Of | role,( |
R512 | T644 | T643 | arg2Of | NF-κB,of |
R513 | T647 | T648 | arg1Of | development,and |
R514 | T648 | T645 | arg2Of | and,in |
R515 | T648 | T646 | arg1Of | and,the |
R516 | T648 | T650 | arg1Of | and,of |
R517 | T649 | T648 | arg2Of | progression,and |
R518 | T651 | T650 | arg2Of | RA,of |
R519 | T653 | T652 | arg2Of | reviewed,( |
R520 | T653 | T654 | arg1Of | reviewed,in |
R521 | T653 | T655 | arg1Of | reviewed,[ |
R522 | T656 | T655 | arg2Of | 4,[ |
R523 | T657 | T655 | arg3Of | ],[ |
R524 | T658 | T652 | arg3Of | ),( |
R525 | T661 | T659 | arg1Of | course,The |
R526 | T661 | T660 | arg1Of | course,time |
R527 | T661 | T662 | arg1Of | course,of |
R528 | T661 | T665 | arg1Of | course,appears |
R529 | T661 | T667 | arg1Of | course,precede |
R530 | T664 | T662 | arg2Of | activation,of |
R531 | T664 | T663 | arg1Of | activation,NF-κB |
R532 | T665 | T673 | arg1Of | appears,and |
R533 | T667 | T665 | arg2Of | precede,appears |
R534 | T667 | T666 | arg1Of | precede,to |
R535 | T669 | T667 | arg2Of | onset,precede |
R536 | T669 | T668 | arg1Of | onset,the |
R537 | T669 | T670 | arg1Of | onset,of |
R538 | T671 | T670 | arg2Of | disease,of |
R539 | T673 | T672 | arg1Of | and,"," |
R540 | T674 | T675 | arg1Of | blockade,of |
R541 | T674 | T677 | arg1Of | blockade,by |
R542 | T674 | T680 | arg1Of | blockade,decreases |
R543 | T676 | T675 | arg2Of | NF-κB,of |
R544 | T679 | T677 | arg2Of | means,by |
R545 | T679 | T678 | arg1Of | means,different |
R546 | T680 | T673 | arg2Of | decreases,and |
R547 | T680 | T683 | arg1Of | decreases,[ |
R548 | T682 | T680 | arg2Of | severity,decreases |
R549 | T682 | T681 | arg1Of | severity,disease |
R550 | T684 | T683 | arg2Of | "5,6",[ |
R551 | T685 | T683 | arg3Of | ],[ |
R552 | T686 | T687 | arg1Of | Next,to |
R553 | T689 | T687 | arg2Of | role,to |
R554 | T689 | T688 | arg1Of | role,its |
R555 | T689 | T690 | arg1Of | role,in |
R556 | T693 | T690 | arg2Of | expression,in |
R557 | T693 | T691 | arg1Of | expression,proinflammatory |
R558 | T693 | T692 | arg1Of | expression,gene |
R559 | T695 | T696 | arg1Of | NF-κB,is |
R560 | T695 | T698 | arg1Of | NF-κB,essential |
R561 | T695 | T704 | arg1Of | NF-κB,mediating |
R562 | T696 | T686 | arg1Of | is,Next |
R563 | T696 | T694 | arg1Of | is,"," |
R564 | T696 | T697 | arg1Of | is,also |
R565 | T696 | T701 | arg1Of | is,"," |
R566 | T696 | T703 | arg1Of | is,by |
R567 | T698 | T696 | arg2Of | essential,is |
R568 | T698 | T699 | arg1Of | essential,for |
R569 | T700 | T699 | arg2Of | osteoclastogenesis,for |
R570 | T703 | T702 | arg1Of | by,mainly |
R571 | T704 | T703 | arg2Of | mediating,by |
R572 | T706 | T704 | arg2Of | effects,mediating |
R573 | T706 | T705 | arg1Of | effects,the |
R574 | T706 | T707 | arg1Of | effects,of |
R575 | T709 | T707 | arg2Of | activator,of |
R576 | T709 | T708 | arg1Of | activator,receptor |
R577 | T709 | T710 | arg1Of | activator,of |
R578 | T712 | T710 | arg2Of | ligand,of |
R579 | T712 | T711 | arg1Of | ligand,NF-κB |
R580 | T712 | T713 | arg1Of | ligand,( |
R581 | T714 | T713 | arg2Of | RANKL,( |
R582 | T715 | T713 | arg3Of | ),( |
R583 | T716 | T717 | arg1Of | Defects,in |
R584 | T716 | T722 | arg1Of | Defects,are |
R585 | T719 | T717 | arg2Of | regulation,in |
R586 | T719 | T718 | arg1Of | regulation,the |
R587 | T719 | T720 | arg1Of | regulation,of |
R588 | T721 | T720 | arg2Of | osteoclastogenesis,of |
R589 | T722 | T729 | arg1Of | are,in |
R590 | T725 | T722 | arg2Of | cause,are |
R591 | T725 | T723 | arg1Of | cause,the |
R592 | T725 | T724 | arg1Of | cause,major |
R593 | T725 | T726 | arg1Of | cause,of |
R594 | T728 | T726 | arg2Of | erosion,of |
R595 | T728 | T727 | arg1Of | erosion,bone |
R596 | T731 | T729 | arg2Of | diseases,in |
R597 | T731 | T730 | arg1Of | diseases,osteolytic |
R598 | T731 | T733 | arg1Of | diseases,as |
R599 | T733 | T732 | arg1Of | as,such |
R600 | T734 | T733 | arg2Of | RA,as |
R601 | T734 | T735 | arg1Of | RA,[ |
R602 | T736 | T735 | arg2Of | 7,[ |
R603 | T737 | T735 | arg3Of | ],[ |
R604 | T741 | T740 | arg1Of | discoveries,recent |
R605 | T741 | T742 | arg1Of | discoveries,revealing |
R606 | T741 | T765 | arg1Of | discoveries,highlight |
R607 | T745 | T742 | arg2Of | association,revealing |
R608 | T745 | T743 | arg1Of | association,a |
R609 | T745 | T744 | arg1Of | association,genetic |
R610 | T745 | T746 | arg1Of | association,with |
R611 | T748 | T746 | arg2Of | genes,with |
R612 | T748 | T747 | arg1Of | genes,several |
R613 | T748 | T749 | arg1Of | genes,relevant |
R614 | T748 | T753 | arg1Of | genes,"," |
R615 | T748 | T754 | arg1Of | genes,including |
R616 | T749 | T750 | arg1Of | relevant,to |
R617 | T752 | T750 | arg2Of | signalling,to |
R618 | T752 | T751 | arg1Of | signalling,NF-κB |
R619 | T755 | T756 | arg1Of | CD40,"," |
R620 | T756 | T758 | arg1Of | ",","," |
R621 | T757 | T756 | arg2Of | TRAF1,"," |
R622 | T758 | T761 | arg1Of | ",",and |
R623 | T759 | T758 | arg2Of | TNFAIP3,"," |
R624 | T761 | T754 | arg2Of | and,including |
R625 | T761 | T760 | arg1Of | and,"," |
R626 | T762 | T761 | arg2Of | c-REL,and |
R627 | T765 | T738 | arg1Of | highlight,Finally |
R628 | T765 | T739 | arg1Of | highlight,"," |
R629 | T765 | T763 | arg1Of | highlight,"," |
R630 | T765 | T764 | arg1Of | highlight,further |
R631 | T765 | T774 | arg1Of | highlight,[ |
R632 | T767 | T765 | arg2Of | importance,highlight |
R633 | T767 | T766 | arg1Of | importance,the |
R634 | T767 | T768 | arg1Of | importance,of |
R635 | T767 | T771 | arg1Of | importance,in |
R636 | T770 | T768 | arg2Of | activation,of |
R637 | T770 | T769 | arg1Of | activation,NF-κB |
R638 | T773 | T771 | arg2Of | pathogenesis,in |
R639 | T773 | T772 | arg1Of | pathogenesis,RA |
R640 | T775 | T774 | arg2Of | 8,[ |
R641 | T776 | T774 | arg3Of | ],[ |
R1314 | T1848 | T1849 | arg1Of | NF-κB,is |
R1315 | T1848 | T1850 | arg1Of | NF-κB,central |
R1316 | T1849 | T1847 | arg2Of | is,Since |
R1317 | T1849 | T1862 | arg1Of | is,with |
R1318 | T1850 | T1849 | arg2Of | central,is |
R1319 | T1850 | T1851 | arg1Of | central,to |
R1320 | T1853 | T1851 | arg2Of | process,to |
R1321 | T1853 | T1852 | arg1Of | process,the |
R1322 | T1853 | T1854 | arg1Of | process,of |
R1323 | T1853 | T1856 | arg1Of | process,in |
R1324 | T1853 | T1858 | arg1Of | process,"," |
R1325 | T1855 | T1854 | arg2Of | inflammation,of |
R1326 | T1857 | T1856 | arg2Of | RA,in |
R1327 | T1861 | T1858 | arg2Of | deals,"," |
R1328 | T1861 | T1859 | arg1Of | deals,much |
R1329 | T1861 | T1860 | arg1Of | deals,research |
R1330 | T1864 | T1862 | arg2Of | identification,with |
R1331 | T1864 | T1863 | arg1Of | identification,the |
R1332 | T1864 | T1865 | arg1Of | identification,of |
R1333 | T1868 | T1865 | arg2Of | triggers,of |
R1334 | T1868 | T1866 | arg1Of | triggers,the |
R1335 | T1868 | T1867 | arg1Of | triggers,molecular |
R1336 | T1869 | T1870 | arg1Of | that,activate |
R1337 | T1870 | T1847 | arg1Of | activate,Since |
R1338 | T1870 | T1872 | arg1Of | activate,in |
R1339 | T1871 | T1870 | arg2Of | NF-κB,activate |
R1340 | T1873 | T1872 | arg2Of | RA,in |
R1341 | T1874 | T1875 | arg1Of | It,is |
R1342 | T1874 | T1877 | arg2Of | It,accepted |
R1343 | T1877 | T1875 | arg2Of | accepted,is |
R1344 | T1877 | T1876 | arg1Of | accepted,well |
R1345 | T1880 | T1879 | arg1Of | cytokines,proinflammatory |
R1346 | T1880 | T1882 | arg1Of | cytokines,as |
R1347 | T1880 | T1886 | arg1Of | cytokines,play |
R1348 | T1882 | T1881 | arg1Of | as,such |
R1349 | T1883 | T1884 | arg1Of | TNF,and |
R1350 | T1884 | T1882 | arg2Of | and,as |
R1351 | T1885 | T1884 | arg2Of | IL-1,and |
R1352 | T1886 | T1891 | arg1Of | play,and |
R1353 | T1889 | T1886 | arg2Of | role,play |
R1354 | T1889 | T1887 | arg1Of | role,an |
R1355 | T1889 | T1888 | arg1Of | role,important |
R1356 | T1891 | T1877 | arg3Of | and,accepted |
R1357 | T1891 | T1878 | arg1Of | and,that |
R1358 | T1891 | T1890 | arg1Of | and,"," |
R1359 | T1892 | T1893 | arg1Of | administration,of |
R1360 | T1892 | T1896 | arg1Of | administration,is |
R1361 | T1895 | T1893 | arg2Of | antagonists,of |
R1362 | T1895 | T1894 | arg1Of | antagonists,TNF |
R1363 | T1896 | T1891 | arg2Of | is,and |
R1364 | T1899 | T1896 | arg2Of | treatment,is |
R1365 | T1899 | T1897 | arg1Of | treatment,an |
R1366 | T1899 | T1898 | arg1Of | treatment,effective |
R1367 | T1899 | T1900 | arg1Of | treatment,for |
R1368 | T1902 | T1900 | arg2Of | RA,for |
R1369 | T1902 | T1901 | arg1Of | RA,severe |
R1370 | T1902 | T1903 | arg1Of | RA,( |
R1371 | T1904 | T1903 | arg2Of | reviewed,( |
R1372 | T1904 | T1905 | arg1Of | reviewed,in |
R1373 | T1904 | T1906 | arg1Of | reviewed,[ |
R1374 | T1907 | T1906 | arg2Of | 9,[ |
R1375 | T1908 | T1906 | arg3Of | ],[ |
R1376 | T1909 | T1903 | arg3Of | ),( |
R1377 | T1910 | T1911 | arg1Of | TNF,and |
R1378 | T1911 | T1913 | arg1Of | and,are |
R1379 | T1912 | T1911 | arg2Of | IL-1,and |
R1380 | T1913 | T1920 | arg1Of | are,and |
R1381 | T1916 | T1915 | arg1Of | potent,very |
R1382 | T1917 | T1913 | arg2Of | activators,are |
R1383 | T1917 | T1914 | arg1Of | activators,both |
R1384 | T1917 | T1916 | arg1Of | activators,potent |
R1385 | T1917 | T1918 | arg1Of | activators,of |
R1386 | T1919 | T1918 | arg2Of | NF-κB,of |
R1387 | T1921 | T1922 | arg1Of | it,can |
R1388 | T1921 | T1923 | arg1Of | it,be |
R1389 | T1921 | T1924 | arg2Of | it,expected |
R1390 | T1924 | T1920 | arg2Of | expected,and |
R1391 | T1924 | T1922 | arg2Of | expected,can |
R1392 | T1924 | T1923 | arg2Of | expected,be |
R1393 | T1927 | T1926 | arg1Of | activation,NF-κB |
R1394 | T1927 | T1928 | arg1Of | activation,by |
R1395 | T1927 | T1931 | arg1Of | activation,mediates |
R1396 | T1930 | T1928 | arg2Of | cytokines,by |
R1397 | T1930 | T1929 | arg1Of | cytokines,these |
R1398 | T1931 | T1924 | arg3Of | mediates,expected |
R1399 | T1931 | T1925 | arg1Of | mediates,that |
R1400 | T1932 | T1931 | arg2Of | most,mediates |
R1401 | T1932 | T1933 | arg1Of | most,of |
R1402 | T1936 | T1933 | arg2Of | activities,of |
R1403 | T1936 | T1934 | arg1Of | activities,their |
R1404 | T1936 | T1935 | arg1Of | activities,pro-inflammatory |
R1405 | T1936 | T1937 | arg1Of | activities,in |
R1406 | T1938 | T1937 | arg2Of | RA,in |
R1407 | T1938 | T1939 | arg1Of | RA,( |
R1408 | T1940 | T1939 | arg2Of | reviewed,( |
R1409 | T1940 | T1941 | arg1Of | reviewed,in |
R1410 | T1940 | T1942 | arg1Of | reviewed,[ |
R1411 | T1943 | T1942 | arg2Of | 3,[ |
R1412 | T1944 | T1942 | arg3Of | ],[ |
R1413 | T1945 | T1939 | arg3Of | ),( |
R1414 | T1947 | T1946 | arg1Of | activation,NF-κB |
R1415 | T1947 | T1948 | arg1Of | activation,by |
R1416 | T1947 | T1963 | arg1Of | activation,is |
R1417 | T1947 | T1964 | arg1Of | activation,important |
R1418 | T1950 | T1948 | arg2Of | activator,by |
R1419 | T1950 | T1949 | arg1Of | activator,receptor |
R1420 | T1950 | T1951 | arg1Of | activator,of |
R1421 | T1952 | T1951 | arg2Of | NF-κB,of |
R1422 | T1952 | T1953 | arg1Of | NF-κB,( |
R1423 | T1952 | T1956 | arg1Of | NF-κB,"," |
R1424 | T1954 | T1953 | arg2Of | RANK,( |
R1425 | T1955 | T1953 | arg3Of | ),( |
R1426 | T1961 | T1956 | arg2Of | member,"," |
R1427 | T1961 | T1957 | arg1Of | member,a |
R1428 | T1961 | T1958 | arg1Of | member,TNF |
R1429 | T1961 | T1959 | arg1Of | member,receptor |
R1430 | T1961 | T1960 | arg1Of | member,family |
R1431 | T1963 | T1962 | arg1Of | is,"," |
R1432 | T1963 | T1968 | arg1Of | is,and |
R1433 | T1964 | T1963 | arg2Of | important,is |
R1434 | T1964 | T1965 | arg1Of | important,for |
R1435 | T1966 | T1965 | arg2Of | osteoclastogenesis,for |
R1436 | T1968 | T1967 | arg1Of | and,"," |
R1437 | T1969 | T1970 | arg1Of | defects,in |
R1438 | T1969 | T1974 | arg1Of | defects,are |
R1439 | T1969 | T1975 | arg1Of | defects,likely |
R1440 | T1969 | T1977 | arg1Of | defects,be |
R1441 | T1969 | T1978 | arg2Of | defects,involved |
R1442 | T1973 | T1970 | arg2Of | signalling,in |
R1443 | T1973 | T1971 | arg1Of | signalling,proper |
R1444 | T1973 | T1972 | arg1Of | signalling,RANK-NF-κB |
R1445 | T1974 | T1968 | arg2Of | are,and |
R1446 | T1975 | T1974 | arg2Of | likely,are |
R1447 | T1978 | T1975 | arg2Of | involved,likely |
R1448 | T1978 | T1976 | arg1Of | involved,to |
R1449 | T1978 | T1977 | arg2Of | involved,be |
R1450 | T1978 | T1979 | arg1Of | involved,in |
R1451 | T1981 | T1980 | arg1Of | pathology,RA |
R1452 | T1981 | T1982 | arg1Of | pathology,and |
R1453 | T1982 | T1979 | arg2Of | and,in |
R1454 | T1982 | T1985 | arg2Of | and,associated |
R1455 | T1984 | T1982 | arg2Of | diseases,and |
R1456 | T1984 | T1983 | arg1Of | diseases,other |
R1457 | T1985 | T1986 | arg1Of | associated,with |
R1458 | T1988 | T1986 | arg2Of | loss,with |
R1459 | T1988 | T1987 | arg1Of | loss,bone |
R1460 | T1988 | T1989 | arg1Of | loss,[ |
R1461 | T1990 | T1989 | arg2Of | 7,[ |
R1462 | T1991 | T1989 | arg3Of | ],[ |
R1463 | T1992 | T1993 | arg1Of | CD40,is |
R1464 | T1998 | T1993 | arg2Of | member,is |
R1465 | T1998 | T1994 | arg1Of | member,another |
R1466 | T1998 | T1995 | arg1Of | member,TNF |
R1467 | T1998 | T1996 | arg1Of | member,receptor |
R1468 | T1998 | T1997 | arg1Of | member,family |
R1469 | T1998 | T1999 | arg1Of | member,that |
R1470 | T1998 | T2000 | arg1Of | member,is |
R1471 | T1998 | T2002 | arg2Of | member,expressed |
R1472 | T1998 | T2034 | arg1Of | member,can |
R1473 | T1998 | T2035 | arg1Of | member,be |
R1474 | T1998 | T2036 | arg2Of | member,upregulated |
R1475 | T2002 | T2000 | arg2Of | expressed,is |
R1476 | T2002 | T2001 | arg1Of | expressed,functionally |
R1477 | T2002 | T2003 | arg1Of | expressed,on |
R1478 | T2002 | T2033 | arg1Of | expressed,and |
R1479 | T2005 | T2003 | arg2Of | variety,on |
R1480 | T2005 | T2004 | arg1Of | variety,a |
R1481 | T2005 | T2006 | arg1Of | variety,of |
R1482 | T2008 | T2007 | arg1Of | types,cell |
R1483 | T2008 | T2009 | arg1Of | types,"," |
R1484 | T2008 | T2010 | arg1Of | types,including |
R1485 | T2008 | T2023 | arg1Of | types,"," |
R1486 | T2013 | T2010 | arg2Of | fibroblasts,including |
R1487 | T2013 | T2011 | arg1Of | fibroblasts,smooth |
R1488 | T2013 | T2012 | arg1Of | fibroblasts,muscle |
R1489 | T2013 | T2014 | arg1Of | fibroblasts,from |
R1490 | T2015 | T2016 | arg1Of | normal,and |
R1491 | T2017 | T2016 | arg2Of | RA,and |
R1492 | T2018 | T2015 | arg1Of | patients,normal |
R1493 | T2018 | T2017 | arg1Of | patients,RA |
R1494 | T2018 | T2019 | arg1Of | patients,and |
R1495 | T2019 | T2014 | arg2Of | and,from |
R1496 | T2022 | T2019 | arg2Of | cells,and |
R1497 | T2022 | T2020 | arg1Of | cells,RA |
R1498 | T2022 | T2021 | arg1Of | cells,synovial |
R1499 | T2023 | T2006 | arg2Of | ",",of |
R1500 | T2025 | T2024 | arg1Of | cells,B |
R1501 | T2025 | T2026 | arg1Of | cells,"," |
R1502 | T2026 | T2029 | arg1Of | ",",and |
R1503 | T2027 | T2026 | arg2Of | macrophages,"," |
R1504 | T2029 | T2023 | arg2Of | and,"," |
R1505 | T2029 | T2028 | arg1Of | and,"," |
R1506 | T2031 | T2029 | arg2Of | cells,and |
R1507 | T2031 | T2030 | arg1Of | cells,dendritic |
R1508 | T2033 | T2032 | arg1Of | and,"," |
R1509 | T2036 | T2033 | arg2Of | upregulated,and |
R1510 | T2036 | T2034 | arg2Of | upregulated,can |
R1511 | T2036 | T2035 | arg2Of | upregulated,be |
R1512 | T2039 | T2036 | arg1Of | cytokines,upregulated |
R1513 | T2039 | T2037 | arg2Of | cytokines,by |
R1514 | T2039 | T2038 | arg1Of | cytokines,proinflammatory |
R1515 | T2039 | T2040 | arg1Of | cytokines,including |
R1516 | T2041 | T2040 | arg2Of | TNF,including |
R1517 | T2041 | T2042 | arg1Of | TNF,[ |
R1518 | T2043 | T2042 | arg2Of | 10,[ |
R1519 | T2044 | T2042 | arg3Of | ],[ |
R1520 | T2045 | T2046 | arg1Of | Binding,of |
R1521 | T2045 | T2067 | arg1Of | Binding,triggers |
R1522 | T2049 | T2046 | arg2Of | ligand,of |
R1523 | T2049 | T2047 | arg1Of | ligand,the |
R1524 | T2049 | T2048 | arg1Of | ligand,CD40 |
R1525 | T2049 | T2050 | arg1Of | ligand,( |
R1526 | T2049 | T2053 | arg1Of | ligand,"," |
R1527 | T2049 | T2054 | arg1Of | ligand,which |
R1528 | T2049 | T2055 | arg1Of | ligand,is |
R1529 | T2049 | T2057 | arg2Of | ligand,expressed |
R1530 | T2051 | T2050 | arg2Of | CD154,( |
R1531 | T2052 | T2050 | arg3Of | ),( |
R1532 | T2057 | T2055 | arg2Of | expressed,is |
R1533 | T2057 | T2056 | arg1Of | expressed,transiently |
R1534 | T2057 | T2058 | arg1Of | expressed,on |
R1535 | T2060 | T2058 | arg2Of | surface,on |
R1536 | T2060 | T2059 | arg1Of | surface,the |
R1537 | T2060 | T2061 | arg1Of | surface,of |
R1538 | T2065 | T2061 | arg2Of | cells,of |
R1539 | T2065 | T2062 | arg2Of | cells,activated |
R1540 | T2065 | T2063 | arg1Of | cells,CD4+ |
R1541 | T2065 | T2064 | arg1Of | cells,T |
R1542 | T2067 | T2066 | arg1Of | triggers,"," |
R1543 | T2069 | T2067 | arg2Of | activation,triggers |
R1544 | T2069 | T2068 | arg1Of | activation,NF-κB |
R1545 | T2069 | T2070 | arg1Of | activation,resulting |
R1546 | T2070 | T2071 | arg1Of | resulting,in |
R1547 | T2073 | T2072 | arg1Of | proliferation,fibroblast |
R1548 | T2073 | T2074 | arg1Of | proliferation,and |
R1549 | T2074 | T2071 | arg2Of | and,in |
R1550 | T2074 | T2081 | arg1Of | and,"," |
R1551 | T2074 | T2082 | arg1Of | and,which |
R1552 | T2074 | T2083 | arg1Of | and,contributes |
R1553 | T2075 | T2074 | arg2Of | secretion,and |
R1554 | T2075 | T2076 | arg1Of | secretion,of |
R1555 | T2078 | T2077 | arg1Of | cytokines,proinflammatory |
R1556 | T2078 | T2079 | arg1Of | cytokines,and |
R1557 | T2079 | T2076 | arg2Of | and,of |
R1558 | T2080 | T2079 | arg2Of | chemokines,and |
R1559 | T2083 | T2084 | arg1Of | contributes,to |
R1560 | T2086 | T2084 | arg2Of | destruction,to |
R1561 | T2086 | T2085 | arg1Of | destruction,joint |
R1562 | T2089 | T2090 | arg1Of | studies,with |
R1563 | T2089 | T2096 | arg1Of | studies,led |
R1564 | T2089 | T2115 | arg1Of | studies,are |
R1565 | T2089 | T2117 | arg2Of | studies,required |
R1566 | T2092 | T2091 | arg1Of | anti-CD40,antagonistic |
R1567 | T2092 | T2093 | arg1Of | anti-CD40,or |
R1568 | T2093 | T2090 | arg2Of | or,with |
R1569 | T2095 | T2093 | arg2Of | antibodies,or |
R1570 | T2095 | T2094 | arg1Of | antibodies,anti-CD154 |
R1571 | T2096 | T2097 | arg1Of | led,to |
R1572 | T2096 | T2114 | arg1Of | led,but |
R1573 | T2099 | T2097 | arg2Of | conclusion,to |
R1574 | T2099 | T2098 | arg1Of | conclusion,the |
R1575 | T2102 | T2101 | arg1Of | signals,CD40 |
R1576 | T2102 | T2103 | arg1Of | signals,may |
R1577 | T2102 | T2104 | arg1Of | signals,be |
R1578 | T2102 | T2105 | arg1Of | signals,important |
R1579 | T2104 | T2099 | arg2Of | be,conclusion |
R1580 | T2104 | T2100 | arg1Of | be,that |
R1581 | T2104 | T2103 | arg2Of | be,may |
R1582 | T2105 | T2104 | arg2Of | important,be |
R1583 | T2105 | T2106 | arg1Of | important,at |
R1584 | T2109 | T2106 | arg2Of | stages,at |
R1585 | T2109 | T2107 | arg1Of | stages,the |
R1586 | T2109 | T2108 | arg1Of | stages,initial |
R1587 | T2109 | T2110 | arg1Of | stages,of |
R1588 | T2112 | T2110 | arg2Of | induction,of |
R1589 | T2112 | T2111 | arg1Of | induction,arthritis |
R1590 | T2114 | T2087 | arg1Of | but,However |
R1591 | T2114 | T2088 | arg1Of | but,"," |
R1592 | T2114 | T2113 | arg1Of | but,"," |
R1593 | T2117 | T2114 | arg2Of | required,but |
R1594 | T2117 | T2115 | arg2Of | required,are |
R1595 | T2117 | T2116 | arg1Of | required,not |
R1596 | T2117 | T2118 | arg1Of | required,once |
R1597 | T2119 | T2120 | arg1Of | disease,is |
R1598 | T2119 | T2121 | arg2Of | disease,established |
R1599 | T2121 | T2120 | arg2Of | established,is |
R1600 | T2121 | T2122 | arg1Of | established,and |
R1601 | T2122 | T2118 | arg2Of | and,once |
R1602 | T2124 | T2123 | arg1Of | antibodies,pathogenic |
R1603 | T2124 | T2125 | arg1Of | antibodies,are |
R1604 | T2124 | T2127 | arg1Of | antibodies,present |
R1605 | T2125 | T2122 | arg2Of | are,and |
R1606 | T2125 | T2126 | arg1Of | are,already |
R1607 | T2125 | T2128 | arg1Of | are,[ |
R1608 | T2127 | T2125 | arg2Of | present,are |
R1609 | T2129 | T2128 | arg2Of | "11,12",[ |
R1610 | T2130 | T2128 | arg3Of | ],[ |
R1611 | T2132 | T2131 | arg2Of | expression,Enhanced |
R1612 | T2132 | T2133 | arg1Of | expression,of |
R1613 | T2132 | T2155 | arg1Of | expression,is |
R1614 | T2132 | T2157 | arg1Of | expression,characteristic |
R1615 | T2139 | T2133 | arg2Of | B-cell,of |
R1616 | T2139 | T2134 | arg1Of | B-cell,the |
R1617 | T2139 | T2135 | arg1Of | B-cell,TNF |
R1618 | T2139 | T2136 | arg1Of | B-cell,receptor |
R1619 | T2139 | T2137 | arg1Of | B-cell,family |
R1620 | T2139 | T2138 | arg1Of | B-cell,member |
R1621 | T2139 | T2140 | arg1Of | B-cell,activating |
R1622 | T2140 | T2145 | arg1Of | activating,"," |
R1623 | T2140 | T2146 | modOf | activating,allowing |
R1624 | T2141 | T2140 | arg2Of | factor,activating |
R1625 | T2141 | T2142 | arg1Of | factor,( |
R1626 | T2143 | T2142 | arg2Of | BAFF,( |
R1627 | T2144 | T2142 | arg3Of | ),( |
R1628 | T2148 | T2146 | arg2Of | survival,allowing |
R1629 | T2148 | T2147 | arg1Of | survival,the |
R1630 | T2148 | T2149 | arg1Of | survival,of |
R1631 | T2148 | T2151 | arg1Of | survival,producing |
R1632 | T2150 | T2149 | arg2Of | autoantibody-,of |
R1633 | T2153 | T2151 | arg2Of | lymphocytes,producing |
R1634 | T2153 | T2152 | arg1Of | lymphocytes,B |
R1635 | T2155 | T2154 | arg1Of | is,"," |
R1636 | T2155 | T2156 | arg1Of | is,also |
R1637 | T2155 | T2161 | arg1Of | is,and |
R1638 | T2157 | T2155 | arg2Of | characteristic,is |
R1639 | T2157 | T2158 | arg1Of | characteristic,for |
R1640 | T2159 | T2158 | arg2Of | RA,for |
R1641 | T2161 | T2160 | arg1Of | and,"," |
R1642 | T2162 | T2163 | arg1Of | antagonists,of |
R1643 | T2162 | T2165 | arg1Of | antagonists,have |
R1644 | T2162 | T2166 | arg1Of | antagonists,been |
R1645 | T2162 | T2167 | arg2Of | antagonists,developed |
R1646 | T2164 | T2163 | arg2Of | BAFF,of |
R1647 | T2167 | T2161 | arg2Of | developed,and |
R1648 | T2167 | T2165 | arg2Of | developed,have |
R1649 | T2167 | T2166 | arg2Of | developed,been |
R1650 | T2167 | T2168 | modOf | developed,to |
R1651 | T2169 | T2168 | arg1Of | counter,to |
R1652 | T2170 | T2169 | arg2Of | RA,counter |
R1653 | T2170 | T2171 | arg1Of | RA,[ |
R1654 | T2172 | T2171 | arg2Of | 13,[ |
R1655 | T2173 | T2171 | arg3Of | ],[ |
R1656 | T2179 | T2176 | arg1Of | signalling,lymphotoxin |
R1657 | T2179 | T2177 | arg1Of | signalling,β |
R1658 | T2179 | T2178 | arg1Of | signalling,receptor |
R1659 | T2179 | T2180 | arg1Of | signalling,has |
R1660 | T2179 | T2181 | arg1Of | signalling,been |
R1661 | T2179 | T2182 | arg2Of | signalling,implicated |
R1662 | T2182 | T2174 | arg1Of | implicated,Finally |
R1663 | T2182 | T2175 | arg1Of | implicated,"," |
R1664 | T2182 | T2180 | arg2Of | implicated,has |
R1665 | T2182 | T2181 | arg2Of | implicated,been |
R1666 | T2182 | T2183 | arg1Of | implicated,in |
R1667 | T2187 | T2183 | arg2Of | formation,in |
R1668 | T2187 | T2184 | arg1Of | formation,tertiary |
R1669 | T2187 | T2185 | arg1Of | formation,lymphoid |
R1670 | T2187 | T2186 | arg1Of | formation,organ |
R1671 | T2187 | T2188 | arg1Of | formation,at |
R1672 | T2189 | T2188 | arg2Of | sites,at |
R1673 | T2189 | T2190 | arg1Of | sites,of |
R1674 | T2192 | T2190 | arg2Of | inflammation,of |
R1675 | T2192 | T2191 | arg1Of | inflammation,chronic |
R1676 | T2192 | T2193 | arg1Of | inflammation,including |
R1677 | T2194 | T2193 | arg2Of | RA,including |
R1678 | T2194 | T2195 | arg1Of | RA,[ |
R1679 | T2196 | T2195 | arg2Of | 13,[ |
R1680 | T2197 | T2195 | arg3Of | ],[ |
R1681 | T2199 | T2198 | arg1Of | receptors,Toll-like |
R1682 | T2199 | T2200 | arg1Of | receptors,( |
R1683 | T2199 | T2203 | arg1Of | receptors,have |
R1684 | T2199 | T2204 | arg1Of | receptors,been |
R1685 | T2199 | T2205 | arg2Of | receptors,implicated |
R1686 | T2199 | T2213 | arg1Of | receptors,are |
R1687 | T2201 | T2200 | arg2Of | TLRs,( |
R1688 | T2202 | T2200 | arg3Of | ),( |
R1689 | T2205 | T2203 | arg2Of | implicated,have |
R1690 | T2205 | T2204 | arg2Of | implicated,been |
R1691 | T2205 | T2206 | arg1Of | implicated,in |
R1692 | T2205 | T2212 | arg1Of | implicated,and |
R1693 | T2208 | T2206 | arg2Of | variety,in |
R1694 | T2208 | T2207 | arg1Of | variety,a |
R1695 | T2208 | T2209 | arg1Of | variety,of |
R1696 | T2211 | T2209 | arg2Of | diseases,of |
R1697 | T2211 | T2210 | arg1Of | diseases,autoimmune |
R1698 | T2213 | T2212 | arg2Of | are,and |
R1699 | T2215 | T2213 | arg2Of | candidates,are |
R1700 | T2215 | T2214 | arg1Of | candidates,potential |
R1701 | T2215 | T2216 | arg1Of | candidates,for |
R1702 | T2217 | T2216 | arg2Of | inducing,for |
R1703 | T2217 | T2220 | arg1Of | inducing,in |
R1704 | T2219 | T2217 | arg2Of | inflammation,inducing |
R1705 | T2219 | T2218 | arg1Of | inflammation,NF-κB-dependent |
R1706 | T2221 | T2220 | arg2Of | RA,in |
R1707 | T2223 | T2222 | arg2Of | addition,In |
R1708 | T2223 | T2224 | arg1Of | addition,to |
R1709 | T2226 | T2224 | arg2Of | ligands,to |
R1710 | T2226 | T2225 | arg1Of | ligands,microbial |
R1711 | T2230 | T2228 | arg1Of | number,an |
R1712 | T2230 | T2229 | arg1Of | number,increasing |
R1713 | T2230 | T2231 | arg1Of | number,of |
R1714 | T2230 | T2234 | arg1Of | number,- |
R1715 | T2230 | T2246 | arg1Of | number,have |
R1716 | T2230 | T2247 | arg1Of | number,been |
R1717 | T2230 | T2248 | arg2Of | number,reported |
R1718 | T2233 | T2231 | arg2Of | ligands,of |
R1719 | T2233 | T2232 | arg1Of | ligands,endogenous |
R1720 | T2236 | T2234 | arg2Of | group,- |
R1721 | T2236 | T2235 | arg1Of | group,a |
R1722 | T2236 | T2237 | arg1Of | group,of |
R1723 | T2238 | T2237 | arg2Of | proteins,of |
R1724 | T2238 | T2239 | arg2Of | proteins,derived |
R1725 | T2239 | T2240 | arg1Of | derived,from |
R1726 | T2242 | T2241 | arg1Of | tissues,host |
R1727 | T2242 | T2243 | arg1Of | tissues,and |
R1728 | T2243 | T2240 | arg2Of | and,from |
R1729 | T2244 | T2243 | arg2Of | cells,and |
R1730 | T2244 | T2245 | arg1Of | cells,- |
R1731 | T2248 | T2222 | arg1Of | reported,In |
R1732 | T2248 | T2227 | arg1Of | reported,"," |
R1733 | T2248 | T2246 | arg2Of | reported,have |
R1734 | T2248 | T2247 | arg2Of | reported,been |
R1735 | T2248 | T2249 | arg1Of | reported,as |
R1736 | T2251 | T2249 | arg2Of | activators,as |
R1737 | T2251 | T2250 | arg1Of | activators,candidate |
R1738 | T2251 | T2252 | arg1Of | activators,of |
R1739 | T2253 | T2252 | arg2Of | TLRs,of |
R1740 | T2253 | T2254 | arg1Of | TLRs,inducing |
R1741 | T2257 | T2254 | arg2Of | inflammation,inducing |
R1742 | T2257 | T2255 | arg1Of | inflammation,so-called |
R1743 | T2257 | T2256 | arg1Of | inflammation,sterile |
R1744 | T2257 | T2258 | arg1Of | inflammation,( |
R1745 | T2259 | T2258 | arg2Of | reviewed,( |
R1746 | T2259 | T2260 | arg1Of | reviewed,in |
R1747 | T2259 | T2261 | arg1Of | reviewed,[ |
R1748 | T2262 | T2261 | arg2Of | "14,15",[ |
R1749 | T2263 | T2261 | arg3Of | ],[ |
R1750 | T2264 | T2258 | arg3Of | ),( |
R1751 | T2265 | T2266 | arg1Of | TLRs,are |
R1752 | T2265 | T2267 | arg2Of | TLRs,expressed |
R1753 | T2267 | T2266 | arg2Of | expressed,are |
R1754 | T2267 | T2268 | arg1Of | expressed,in |
R1755 | T2269 | T2268 | arg2Of | RA,in |
R1756 | T2271 | T2270 | arg1Of | tissues,synovial |
R1757 | T2271 | T2272 | arg1Of | tissues,and |
R1758 | T2272 | T2276 | arg1Of | and,are |
R1759 | T2272 | T2277 | arg1Of | and,present |
R1760 | T2275 | T2272 | arg2Of | ligands,and |
R1761 | T2275 | T2273 | arg1Of | ligands,various |
R1762 | T2275 | T2274 | arg1Of | ligands,endogenous |
R1763 | T2276 | T2266 | modOf | are,are |
R1764 | T2277 | T2276 | arg2Of | present,are |
R1765 | T2277 | T2278 | arg1Of | present,within |
R1766 | T2281 | T2278 | arg2Of | joints,within |
R1767 | T2281 | T2279 | arg1Of | joints,the |
R1768 | T2281 | T2280 | arg1Of | joints,inflamed |
R1769 | T2281 | T2282 | arg1Of | joints,of |
R1770 | T2284 | T2282 | arg2Of | patients,of |
R1771 | T2284 | T2283 | arg1Of | patients,RA |
R1772 | T2288 | T2287 | arg1Of | models,animal |
R1773 | T2288 | T2289 | arg1Of | models,using |
R1774 | T2288 | T2300 | arg1Of | models,identify |
R1775 | T2292 | T2290 | arg1Of | mice,TLR |
R1776 | T2292 | T2291 | arg1Of | mice,knockout |
R1777 | T2292 | T2293 | arg1Of | mice,or |
R1778 | T2293 | T2289 | arg2Of | or,using |
R1779 | T2294 | T2293 | arg2Of | strategies,or |
R1780 | T2294 | T2295 | modOf | strategies,to |
R1781 | T2296 | T2295 | arg1Of | block,to |
R1782 | T2298 | T2296 | arg2Of | signalling,block |
R1783 | T2298 | T2297 | arg1Of | signalling,TLR |
R1784 | T2300 | T2285 | arg1Of | identify,Moreover |
R1785 | T2300 | T2286 | arg1Of | identify,"," |
R1786 | T2300 | T2299 | arg1Of | identify,clearly |
R1787 | T2300 | T2303 | arg1Of | identify,as |
R1788 | T2302 | T2300 | arg2Of | inflammation,identify |
R1789 | T2302 | T2301 | arg1Of | inflammation,TLR-dependent |
R1790 | T2304 | T2303 | arg2Of | being,as |
R1791 | T2304 | T2306 | arg1Of | being,in |
R1792 | T2305 | T2304 | arg2Of | important,being |
R1793 | T2308 | T2306 | arg2Of | pathogenesis,in |
R1794 | T2308 | T2307 | arg1Of | pathogenesis,the |
R1795 | T2308 | T2309 | arg1Of | pathogenesis,of |
R1796 | T2311 | T2309 | arg2Of | disease,of |
R1797 | T2311 | T2310 | arg1Of | disease,the |
R1798 | T2317 | T2312 | arg1Of | protein,High |
R1799 | T2317 | T2313 | arg1Of | protein,mobility |
R1800 | T2317 | T2314 | arg1Of | protein,group |
R1801 | T2317 | T2315 | arg1Of | protein,box |
R1802 | T2317 | T2316 | arg1Of | protein,chromosomal |
R1803 | T2317 | T2318 | arg1Of | protein,1 |
R1804 | T2317 | T2319 | arg1Of | protein,( |
R1805 | T2317 | T2322 | arg1Of | protein,"," |
R1806 | T2317 | T2342 | arg1Of | protein,is |
R1807 | T2320 | T2319 | arg2Of | HMGB1,( |
R1808 | T2321 | T2319 | arg3Of | ),( |
R1809 | T2325 | T2324 | arg1Of | conserved,highly |
R1810 | T2327 | T2322 | arg2Of | component,"," |
R1811 | T2327 | T2323 | arg1Of | component,a |
R1812 | T2327 | T2325 | arg1Of | component,conserved |
R1813 | T2327 | T2326 | arg1Of | component,chromatin |
R1814 | T2327 | T2328 | arg1Of | component,that |
R1815 | T2327 | T2329 | arg1Of | component,can |
R1816 | T2327 | T2330 | arg1Of | component,be |
R1817 | T2327 | T2332 | arg2Of | component,secreted |
R1818 | T2327 | T2337 | arg2Of | component,released |
R1819 | T2332 | T2335 | arg1Of | secreted,or |
R1820 | T2334 | T2332 | arg1Of | macrophages,secreted |
R1821 | T2334 | T2333 | arg2Of | macrophages,by |
R1822 | T2335 | T2329 | arg2Of | or,can |
R1823 | T2335 | T2330 | arg2Of | or,be |
R1824 | T2335 | T2331 | arg1Of | or,actively |
R1825 | T2337 | T2335 | arg2Of | released,or |
R1826 | T2337 | T2336 | arg1Of | released,passively |
R1827 | T2340 | T2337 | arg1Of | cells,released |
R1828 | T2340 | T2338 | arg2Of | cells,by |
R1829 | T2340 | T2339 | arg1Of | cells,necrotic |
R1830 | T2342 | T2341 | arg1Of | is,"," |
R1831 | T2343 | T2342 | arg2Of | one,is |
R1832 | T2343 | T2344 | arg1Of | one,of |
R1833 | T2348 | T2346 | arg1Of | endogenous,most |
R1834 | T2348 | T2347 | arg1Of | endogenous,putative |
R1835 | T2350 | T2344 | arg2Of | ligands,of |
R1836 | T2350 | T2345 | arg1Of | ligands,the |
R1837 | T2350 | T2348 | arg1Of | ligands,endogenous |
R1838 | T2350 | T2349 | arg1Of | ligands,TLR4 |
R1839 | T2350 | T2351 | arg2Of | ligands,involved |
R1840 | T2351 | T2352 | arg1Of | involved,in |
R1841 | T2354 | T2352 | arg2Of | pathology,in |
R1842 | T2354 | T2353 | arg1Of | pathology,RA |
R1843 | T2355 | T2356 | arg1Of | HMGB1,is |
R1844 | T2355 | T2357 | arg2Of | HMGB1,increased |
R1845 | T2357 | T2356 | arg2Of | increased,is |
R1846 | T2357 | T2358 | arg1Of | increased,in |
R1847 | T2357 | T2374 | arg1Of | increased,against |
R1848 | T2361 | T2359 | arg1Of | tissue,RA |
R1849 | T2361 | T2360 | arg1Of | tissue,synovial |
R1850 | T2361 | T2362 | arg1Of | tissue,and |
R1851 | T2362 | T2366 | arg1Of | and,or |
R1852 | T2365 | T2362 | arg2Of | antibodies,and |
R1853 | T2365 | T2363 | arg1Of | antibodies,HMGB1 |
R1854 | T2365 | T2364 | arg1Of | antibodies,neutralising |
R1855 | T2366 | T2358 | arg2Of | or,in |
R1856 | T2370 | T2366 | arg2Of | domain,or |
R1857 | T2370 | T2367 | arg1Of | domain,the |
R1858 | T2370 | T2368 | arg1Of | domain,antagonistic |
R1859 | T2370 | T2369 | arg1Of | domain,BoxA |
R1860 | T2370 | T2371 | arg1Of | domain,of |
R1861 | T2373 | T2371 | arg2Of | protect,of |
R1862 | T2373 | T2372 | arg1Of | protect,HMGB1 |
R1863 | T2376 | T2374 | arg2Of | arthritis,against |
R1864 | T2376 | T2375 | arg1Of | arthritis,collagen-induced |
R1865 | T2376 | T2377 | arg1Of | arthritis,in |
R1866 | T2378 | T2377 | arg2Of | mice,in |
R1867 | T2378 | T2379 | arg1Of | mice,[ |
R1868 | T2380 | T2379 | arg2Of | 16,[ |
R1869 | T2381 | T2379 | arg3Of | ],[ |
R1870 | T2383 | T2382 | arg1Of | protein,Myeloid-related |
R1871 | T2383 | T2384 | arg1Of | protein,8 |
R1872 | T2383 | T2385 | arg1Of | protein,and |
R1873 | T2385 | T2389 | arg1Of | and,"," |
R1874 | T2385 | T2403 | arg1Of | and,are |
R1875 | T2385 | T2406 | arg1Of | and,present |
R1876 | T2385 | T2413 | arg1Of | and,have |
R1877 | T2385 | T2414 | arg1Of | and,been |
R1878 | T2385 | T2415 | arg2Of | and,suggested |
R1879 | T2385 | T2417 | arg1Of | and,be |
R1880 | T2385 | T2418 | arg2Of | and,involved |
R1881 | T2387 | T2385 | arg2Of | protein,and |
R1882 | T2387 | T2386 | arg1Of | protein,myeloid-related |
R1883 | T2387 | T2388 | arg1Of | protein,14 |
R1884 | T2393 | T2389 | arg2Of | molecules,"," |
R1885 | T2393 | T2390 | arg1Of | molecules,damage-associated |
R1886 | T2393 | T2391 | arg1Of | molecules,molecular |
R1887 | T2393 | T2392 | arg1Of | molecules,pattern |
R1888 | T2393 | T2394 | arg1Of | molecules,belonging |
R1889 | T2394 | T2395 | arg1Of | belonging,to |
R1890 | T2398 | T2395 | arg2Of | family,to |
R1891 | T2398 | T2396 | arg1Of | family,the |
R1892 | T2398 | T2397 | arg1Of | family,S100 |
R1893 | T2398 | T2399 | arg1Of | family,of |
R1894 | T2401 | T2399 | arg2Of | proteins,of |
R1895 | T2401 | T2400 | arg1Of | proteins,calcium-binding |
R1896 | T2403 | T2404 | arg1Of | are,also |
R1897 | T2403 | T2412 | arg1Of | are,and |
R1898 | T2406 | T2403 | arg2Of | present,are |
R1899 | T2406 | T2405 | arg1Of | present,abundantly |
R1900 | T2406 | T2407 | arg1Of | present,in |
R1901 | T2410 | T2407 | arg2Of | fluid,in |
R1902 | T2410 | T2408 | arg1Of | fluid,RA |
R1903 | T2410 | T2409 | arg1Of | fluid,synovial |
R1904 | T2412 | T2402 | arg1Of | and,"," |
R1905 | T2412 | T2411 | arg1Of | and,"," |
R1906 | T2415 | T2412 | arg2Of | suggested,and |
R1907 | T2415 | T2413 | arg2Of | suggested,have |
R1908 | T2415 | T2414 | arg2Of | suggested,been |
R1909 | T2418 | T2415 | arg3Of | involved,suggested |
R1910 | T2418 | T2416 | arg1Of | involved,to |
R1911 | T2418 | T2417 | arg2Of | involved,be |
R1912 | T2418 | T2419 | arg1Of | involved,in |
R1913 | T2418 | T2423 | arg1Of | involved,in |
R1914 | T2422 | T2419 | arg2Of | inflammation,in |
R1915 | T2422 | T2420 | arg1Of | inflammation,TLR4-induced |
R1916 | T2422 | T2421 | arg1Of | inflammation,chronic |
R1917 | T2424 | T2423 | arg2Of | RA,in |
R1918 | T2424 | T2425 | arg1Of | RA,[ |
R1919 | T2426 | T2425 | arg2Of | "17,18",[ |
R1920 | T2427 | T2425 | arg3Of | ],[ |
R1921 | T2431 | T2428 | arg1Of | ligands,Other |
R1922 | T2431 | T2429 | arg1Of | ligands,endogenous |
R1923 | T2431 | T2430 | arg1Of | ligands,TLR |
R1924 | T2431 | T2432 | arg1Of | ligands,that |
R1925 | T2431 | T2433 | arg1Of | ligands,may |
R1926 | T2431 | T2434 | arg1Of | ligands,be |
R1927 | T2431 | T2435 | arg2Of | ligands,involved |
R1928 | T2431 | T2439 | arg1Of | ligands,are |
R1929 | T2435 | T2433 | arg2Of | involved,may |
R1930 | T2435 | T2434 | arg2Of | involved,be |
R1931 | T2435 | T2436 | arg1Of | involved,in |
R1932 | T2438 | T2436 | arg2Of | pathology,in |
R1936 | T2442 | T2444 | arg1Of | components,as |
R1937 | T2442 | T2454 | arg1Of | components,and |
R1938 | T2444 | T2443 | arg1Of | as,such |
R1939 | T2445 | T2446 | arg1Of | fibrinogen,"," |
R1940 | T2446 | T2448 | arg1Of | ",","," |
R1941 | T2447 | T2446 | arg2Of | fibronectin,"," |
R1942 | T2448 | T2450 | arg1Of | ",","," |
R1943 | T2449 | T2448 | arg2Of | biglycan,"," |
R1944 | T2450 | T2444 | arg2Of | ",",as |
R1945 | T2452 | T2450 | arg2Of | C,"," |
R1946 | T2452 | T2451 | arg1Of | C,tenascin |
R1947 | T2454 | T2439 | arg2Of | and,are |
R1948 | T2454 | T2453 | arg1Of | and,"," |
R1949 | T2457 | T2454 | arg2Of | fragments,and |
R1950 | T2457 | T2455 | arg1Of | fragments,hyal-uronic |
R1951 | T2457 | T2456 | arg1Of | fragments,acid |
R1952 | T2457 | T2458 | arg1Of | fragments,( |
R1953 | T2459 | T2458 | arg2Of | reviewed,( |
R1954 | T2459 | T2460 | arg1Of | reviewed,in |
R1955 | T2459 | T2461 | arg1Of | reviewed,[ |
R1956 | T2462 | T2461 | arg2Of | "14,15",[ |
R1957 | T2463 | T2461 | arg3Of | ],[ |
R1958 | T2464 | T2458 | arg3Of | ),( |
R1959 | T2468 | T2467 | arg1Of | studies,these |
R1960 | T2468 | T2469 | arg1Of | studies,suggest |
R1961 | T2469 | T2465 | arg1Of | suggest,Together |
R1962 | T2469 | T2466 | arg1Of | suggest,"," |
R1963 | T2473 | T2471 | arg1Of | ligands,several |
R1964 | T2473 | T2472 | arg1Of | ligands,TLR |
R1965 | T2473 | T2474 | arg1Of | ligands,in |
R1966 | T2473 | T2479 | arg1Of | ligands,may |
R1967 | T2473 | T2480 | arg1Of | ligands,contribute |
R1968 | T2478 | T2474 | arg2Of | tissue,in |
R1969 | T2478 | T2475 | arg1Of | tissue,the |
R1970 | T2478 | T2476 | arg1Of | tissue,inflamed |
R1971 | T2478 | T2477 | arg1Of | tissue,joint |
R1972 | T2480 | T2469 | arg2Of | contribute,suggest |
R1973 | T2480 | T2470 | arg1Of | contribute,that |
R1974 | T2480 | T2479 | arg2Of | contribute,may |
R1975 | T2480 | T2481 | arg1Of | contribute,to |
R1976 | T2483 | T2482 | arg1Of | activation,NF-κB |
R1977 | T2483 | T2484 | arg1Of | activation,and |
R1978 | T2484 | T2481 | arg2Of | and,to |
R1979 | T2484 | T2488 | arg1Of | and,in |
R1980 | T2487 | T2484 | arg2Of | expression,and |
R1981 | T2487 | T2485 | arg1Of | expression,inflammatory |
R1982 | T2487 | T2486 | arg1Of | expression,gene |
R1983 | T2489 | T2488 | arg2Of | RA,in |
R3033 | T4573 | T4572 | arg1Of | proteins,NF-κB |
R3034 | T4573 | T4574 | arg1Of | proteins,are |
R3035 | T4573 | T4575 | arg2Of | proteins,sequestered |
R3036 | T4575 | T4574 | arg2Of | sequestered,are |
R3037 | T4575 | T4576 | arg1Of | sequestered,in |
R3038 | T4575 | T4579 | arg1Of | sequestered,as |
R3039 | T4575 | T4587 | arg1Of | sequestered,as |
R3040 | T4578 | T4576 | arg2Of | cytoplasm,in |
R3041 | T4578 | T4577 | arg1Of | cytoplasm,the |
R3042 | T4581 | T4579 | arg2Of | complexes,as |
R3043 | T4581 | T4580 | arg1Of | complexes,latent |
R3044 | T4584 | T4575 | arg1Of | proteins,sequestered |
R3045 | T4584 | T4582 | arg2Of | proteins,by |
R3046 | T4584 | T4583 | arg1Of | proteins,inhibitory |
R3047 | T4584 | T4585 | arg2Of | proteins,referred |
R3048 | T4585 | T4586 | arg1Of | referred,to |
R3049 | T4588 | T4587 | arg2Of | inhibitor,as |
R3050 | T4588 | T4589 | arg1Of | inhibitor,of |
R3051 | T4592 | T4591 | arg2Of | IκB,( |
R3052 | T4593 | T4591 | arg3Of | ),( |
R3053 | T4594 | T4589 | arg2Of | proteins,of |
R3054 | T4594 | T4590 | arg1Of | proteins,NF-κB |
R3055 | T4594 | T4591 | arg1Of | proteins,( |
R3056 | T4594 | T4595 | arg1Of | proteins,"," |
R3057 | T4594 | T4596 | arg1Of | proteins,which |
R3058 | T4594 | T4597 | arg1Of | proteins,prevent |
R3059 | T4600 | T4598 | arg1Of | translocation,NF-κB |
R3060 | T4600 | T4599 | arg1Of | translocation,nuclear |
R3061 | T4600 | T4601 | arg1Of | translocation,and |
R3062 | T4601 | T4597 | arg2Of | and,prevent |
R3063 | T4603 | T4601 | arg2Of | binding,and |
R3064 | T4603 | T4602 | arg1Of | binding,DNA |
R3065 | T4603 | T4604 | arg1Of | binding,[ |
R3066 | T4605 | T4604 | arg2Of | 19,[ |
R3067 | T4606 | T4604 | arg3Of | ],[ |
R3068 | T4609 | T4608 | arg1Of | majority,the |
R3069 | T4609 | T4610 | arg1Of | majority,of |
R3070 | T4609 | T4635 | arg1Of | majority,serve |
R3071 | T4611 | T4610 | arg2Of | IκBs,of |
R3072 | T4611 | T4612 | arg1Of | IκBs,( |
R3073 | T4613 | T4614 | arg1Of | IκBα,"," |
R3074 | T4614 | T4616 | arg1Of | ",","," |
R3075 | T4615 | T4614 | arg2Of | IκBβ,"," |
R3076 | T4616 | T4618 | arg1Of | ",","," |
R3077 | T4617 | T4616 | arg2Of | IκBε,"," |
R3078 | T4618 | T4612 | arg2Of | ",",( |
R3079 | T4618 | T4626 | arg1Of | ",","," |
R3080 | T4619 | T4618 | arg2Of | p105,"," |
R3081 | T4619 | T4620 | arg1Of | p105,( |
R3082 | T4622 | T4620 | arg2Of | known,( |
R3083 | T4622 | T4621 | arg1Of | known,also |
R3084 | T4622 | T4623 | arg1Of | known,as |
R3085 | T4624 | T4623 | arg2Of | NF-κB1,as |
R3086 | T4625 | T4620 | arg3Of | ),( |
R3087 | T4627 | T4626 | arg2Of | p100,"," |
R3088 | T4627 | T4628 | arg1Of | p100,( |
R3089 | T4630 | T4628 | arg2Of | known,( |
R3090 | T4630 | T4629 | arg1Of | known,also |
R3091 | T4630 | T4631 | arg1Of | known,as |
R3092 | T4632 | T4631 | arg2Of | NF-κB2,as |
R3093 | T4633 | T4628 | arg3Of | ),( |
R3094 | T4634 | T4612 | arg3Of | ),( |
R3095 | T4635 | T4607 | arg2Of | serve,Whereas |
R3096 | T4635 | T4636 | arg1Of | serve,as |
R3097 | T4637 | T4636 | arg2Of | inhibitors,as |
R3098 | T4637 | T4638 | arg1Of | inhibitors,of |
R3099 | T4639 | T4638 | arg2Of | NF-κB,of |
R3100 | T4641 | T4642 | arg1Of | IκBξ,and |
R3101 | T4642 | T4645 | arg1Of | and,potentiate |
R3102 | T4643 | T4642 | arg2Of | Bcl-3,and |
R3103 | T4645 | T4644 | arg1Of | potentiate,instead |
R3104 | T4645 | T4652 | arg1Of | potentiate,and |
R3105 | T4647 | T4645 | arg2Of | transactivation,potentiate |
R3106 | T4647 | T4646 | arg1Of | transactivation,NF-κB |
R3107 | T4647 | T4648 | arg1Of | transactivation,in |
R3108 | T4651 | T4648 | arg2Of | p100,in |
R3109 | T4651 | T4649 | arg1Of | p100,the |
R3110 | T4651 | T4650 | arg1Of | p100,nucleus. |
R3111 | T4652 | T4607 | arg1Of | and,Whereas |
R3112 | T4652 | T4640 | arg1Of | and,"," |
R3113 | T4653 | T4654 | arg1Of | p105,are |
R3114 | T4654 | T4652 | arg2Of | are,and |
R3115 | T4654 | T4663 | arg1Of | are,"," |
R3116 | T4654 | T4664 | arg1Of | are,respectively |
R3117 | T4655 | T4654 | arg2Of | precursors,are |
R3118 | T4655 | T4656 | arg1Of | precursors,of |
R3119 | T4658 | T4659 | arg1Of | p52,and |
R3120 | T4660 | T4659 | arg2Of | p50,and |
R3121 | T4662 | T4656 | arg2Of | subunits,of |
R3122 | T4662 | T4657 | arg1Of | subunits,the |
R3123 | T4662 | T4658 | arg1Of | subunits,p52 |
R3124 | T4662 | T4660 | arg1Of | subunits,p50 |
R3125 | T4662 | T4661 | arg1Of | subunits,NF-κB |
R3126 | T4665 | T4666 | arg1Of | There,are |
R3127 | T4671 | T4666 | arg2Of | pathways,are |
R3128 | T4671 | T4667 | arg1Of | pathways,two |
R3129 | T4671 | T4668 | arg1Of | pathways,unique |
R3130 | T4671 | T4669 | arg1Of | pathways,NF-κB |
R3131 | T4671 | T4670 | arg1Of | pathways,signalling |
R3132 | T4671 | T4672 | arg1Of | pathways,"," |
R3133 | T4671 | T4673 | arg2Of | pathways,termed |
R3134 | T4674 | T4675 | arg1Of | canonical,( |
R3135 | T4674 | T4679 | arg1Of | canonical,and |
R3136 | T4677 | T4675 | arg2Of | classical,( |
R3137 | T4677 | T4676 | arg1Of | classical,or |
R3138 | T4678 | T4675 | arg3Of | ),( |
R3139 | T4680 | T4681 | arg1Of | noncanonical,( |
R3140 | T4680 | T4682 | arg1Of | noncanonical,or |
R3141 | T4682 | T4679 | arg2Of | or,and |
R3142 | T4685 | T4682 | arg2Of | NF-κB,or |
R3143 | T4685 | T4683 | arg1Of | NF-κB,alternative |
R3144 | T4685 | T4684 | arg1Of | NF-κB,) |
R3145 | T4686 | T4673 | arg3Of | pathways,termed |
R3146 | T4686 | T4674 | arg1Of | pathways,canonical |
R3147 | T4686 | T4680 | arg1Of | pathways,noncanonical |
R3148 | T4686 | T4685 | arg1Of | pathways,NF-κB |
R3149 | T4690 | T4687 | arg1Of | pathway,The |
R3150 | T4690 | T4688 | arg1Of | pathway,canonical |
R3151 | T4690 | T4689 | arg1Of | pathway,NF-κB |
R3152 | T4690 | T4691 | arg1Of | pathway,plays |
R3153 | T4690 | T4702 | arg1Of | pathway,is |
R3154 | T4690 | T4703 | arg2Of | pathway,triggered |
R3155 | T4691 | T4695 | arg1Of | plays,in |
R3156 | T4691 | T4701 | arg1Of | plays,and |
R3157 | T4694 | T4691 | arg2Of | role,plays |
R3158 | T4694 | T4692 | arg1Of | role,a |
R3159 | T4694 | T4693 | arg1Of | role,major |
R3160 | T4696 | T4697 | arg1Of | innate,and |
R3161 | T4698 | T4697 | arg2Of | adaptive,and |
R3162 | T4699 | T4695 | arg2Of | immunity,in |
R3163 | T4699 | T4696 | arg1Of | immunity,innate |
R3164 | T4699 | T4698 | arg1Of | immunity,adaptive |
R3165 | T4701 | T4700 | arg1Of | and,"," |
R3166 | T4703 | T4701 | arg2Of | triggered,and |
R3167 | T4703 | T4702 | arg2Of | triggered,is |
R3168 | T4706 | T4703 | arg1Of | stimuli,triggered |
R3169 | T4706 | T4704 | arg2Of | stimuli,by |
R3170 | T4706 | T4705 | arg1Of | stimuli,many |
R3171 | T4706 | T4707 | arg1Of | stimuli,including |
R3172 | T4709 | T4708 | arg1Of | cytokines,proinflammatory |
R3173 | T4709 | T4710 | arg1Of | cytokines,( |
R3174 | T4709 | T4718 | arg1Of | cytokines,"," |
R3175 | T4711 | T4710 | arg2Of | for,( |
R3176 | T4712 | T4713 | arg1Of | example,"," |
R3177 | T4713 | T4715 | arg1Of | ",","," |
R3178 | T4714 | T4713 | arg2Of | TNF,"," |
R3179 | T4715 | T4711 | arg2Of | ",",for |
R3180 | T4716 | T4715 | arg2Of | IL-1,"," |
R3181 | T4717 | T4710 | arg3Of | ),( |
R3182 | T4718 | T4707 | arg2Of | ",",including |
R3183 | T4719 | T4720 | arg1Of | antigens,"," |
R3184 | T4720 | T4723 | arg1Of | ",",and |
R3185 | T4721 | T4720 | arg2Of | RANKL,"," |
R3186 | T4723 | T4718 | arg2Of | and,"," |
R3187 | T4723 | T4722 | arg1Of | and,"," |
R3188 | T4725 | T4723 | arg2Of | ligands,and |
R3189 | T4725 | T4724 | arg1Of | ligands,TLR |
R3190 | T4727 | T4726 | arg1Of | signalling,NF-κB |
R3191 | T4727 | T4728 | arg2Of | signalling,initiated |
R3192 | T4727 | T4732 | arg1Of | signalling,requires |
R3193 | T4731 | T4728 | arg1Of | receptors,initiated |
R3194 | T4731 | T4729 | arg2Of | receptors,by |
R3195 | T4731 | T4730 | arg1Of | receptors,different |
R3196 | T4734 | T4732 | arg2Of | formation,requires |
R3197 | T4734 | T4733 | arg1Of | formation,the |
R3198 | T4734 | T4735 | arg1Of | formation,of |
R3199 | T4734 | T4759 | arg1Of | formation,"," |
R3200 | T4734 | T4760 | arg1Of | formation,which |
R3201 | T4734 | T4761 | arg1Of | formation,mediates |
R3202 | T4738 | T4735 | arg2Of | interactions,of |
R3203 | T4738 | T4736 | arg1Of | interactions,proximal |
R3204 | T4738 | T4737 | arg1Of | interactions,protein-protein |
R3205 | T4738 | T4739 | arg1Of | interactions,that |
R3206 | T4738 | T4740 | arg1Of | interactions,are |
R3207 | T4738 | T4743 | arg1Of | interactions,specific |
R3208 | T4738 | T4747 | arg1Of | interactions,converge |
R3209 | T4740 | T4741 | arg1Of | are,often |
R3210 | T4740 | T4745 | arg1Of | are,but |
R3211 | T4743 | T4740 | arg2Of | specific,are |
R3212 | T4743 | T4742 | arg1Of | specific,receptor |
R3213 | T4745 | T4744 | arg1Of | but,"," |
R3214 | T4747 | T4745 | arg2Of | converge,but |
R3215 | T4747 | T4746 | arg1Of | converge,ultimately |
R3216 | T4747 | T4748 | arg1Of | converge,in |
R3217 | T4750 | T4748 | arg2Of | activation,in |
R3218 | T4750 | T4749 | arg1Of | activation,the |
R3219 | T4750 | T4751 | arg1Of | activation,of |
R3220 | T4754 | T4753 | arg1Of | kinase,IκB |
R3221 | T4754 | T4755 | arg1Of | kinase,( |
R3222 | T4756 | T4755 | arg2Of | IKK,( |
R3223 | T4757 | T4755 | arg3Of | ),( |
R3224 | T4758 | T4751 | arg2Of | complex,of |
R3225 | T4758 | T4752 | arg1Of | complex,the |
R3226 | T4758 | T4754 | arg1Of | complex,kinase |
R3227 | T4762 | T4761 | arg2Of | phosphorylation,mediates |
R3228 | T4762 | T4763 | arg1Of | phosphorylation,of |
R3229 | T4767 | T4763 | arg2Of | protein,of |
R3230 | T4767 | T4764 | arg1Of | protein,the |
R3231 | T4767 | T4765 | arg1Of | protein,inhibitory |
R3232 | T4767 | T4766 | arg1Of | protein,IκB |
R3233 | T4767 | T4768 | arg1Of | protein,leading |
R3234 | T4768 | T4769 | arg1Of | leading,to |
R3235 | T4768 | T4777 | arg1Of | leading,[ |
R3236 | T4771 | T4772 | arg1Of | K48-polyubiquitination,and |
R3237 | T4772 | T4769 | arg2Of | and,to |
R3238 | T4772 | T4770 | arg1Of | and,its |
R3239 | T4772 | T4774 | arg1Of | and,by |
R3240 | T4773 | T4772 | arg2Of | degradation,and |
R3241 | T4776 | T4774 | arg2Of | proteasome,by |
R3242 | T4776 | T4775 | arg1Of | proteasome,the |
R3243 | T4778 | T4777 | arg2Of | 20,[ |
R3244 | T4779 | T4777 | arg3Of | ],[ |
R3245 | T4782 | T4780 | arg1Of | complex,The |
R3246 | T4782 | T4781 | arg1Of | complex,IKK |
R3247 | T4782 | T4783 | arg1Of | complex,is |
R3248 | T4782 | T4784 | arg2Of | complex,comprised |
R3249 | T4784 | T4783 | arg2Of | comprised,is |
R3250 | T4784 | T4785 | arg1Of | comprised,of |
R3251 | T4784 | T4816 | arg1Of | comprised,( |
R3252 | T4789 | T4787 | arg1Of | subunits,two |
R3253 | T4789 | T4788 | arg1Of | subunits,catalytic |
R3254 | T4790 | T4791 | arg1Of | IKK1,and |
R3255 | T4791 | T4786 | arg1Of | and,the |
R3256 | T4791 | T4789 | arg1Of | and,subunits |
R3257 | T4791 | T4793 | arg1Of | and,( |
R3258 | T4791 | T4801 | arg1Of | and,and |
R3259 | T4792 | T4791 | arg2Of | IKK2,and |
R3260 | T4795 | T4793 | arg2Of | known,( |
R3261 | T4795 | T4794 | arg1Of | known,also |
R3262 | T4795 | T4796 | arg1Of | known,as |
R3263 | T4797 | T4798 | arg1Of | IKKα,and |
R3264 | T4798 | T4796 | arg2Of | and,as |
R3265 | T4799 | T4798 | arg2Of | IKKβ,and |
R3266 | T4800 | T4793 | arg3Of | ),( |
R3267 | T4801 | T4785 | arg2Of | and,of |
R3268 | T4807 | T4801 | arg2Of | modulator,and |
R3269 | T4807 | T4802 | arg1Of | modulator,the |
R3270 | T4807 | T4803 | arg1Of | modulator,regulatory |
R3271 | T4807 | T4804 | arg1Of | modulator,subunit |
R3272 | T4807 | T4805 | arg1Of | modulator,NF-κB |
R3273 | T4807 | T4806 | arg1Of | modulator,essential |
R3274 | T4807 | T4808 | arg1Of | modulator,( |
R3275 | T4809 | T4808 | arg2Of | NEMO,( |
R3276 | T4809 | T4810 | arg1Of | NEMO,- |
R3277 | T4809 | T4812 | arg2Of | NEMO,known |
R3278 | T4812 | T4811 | arg1Of | known,also |
R3279 | T4812 | T4813 | arg1Of | known,as |
R3280 | T4814 | T4813 | arg2Of | IKKγ,as |
R3281 | T4815 | T4808 | arg3Of | ),( |
R3282 | T4817 | T4816 | arg2Of | Figure,( |
R3283 | T4817 | T4818 | arg1Of | Figure,1 |
R3284 | T4819 | T4816 | arg3Of | ),( |
R3285 | T4820 | T4821 | arg1Of | Gene,targeting |
R3286 | T4820 | T4823 | arg1Of | Gene,showed |
R3287 | T4822 | T4821 | arg2Of | experiments,targeting |
R3288 | T4825 | T4826 | arg1Of | IKK2,and |
R3289 | T4826 | T4829 | arg1Of | and,but |
R3290 | T4827 | T4826 | arg2Of | NEMO,and |
R3291 | T4829 | T4828 | arg1Of | but,"," |
R3292 | T4829 | T4830 | arg1Of | but,not |
R3293 | T4829 | T4833 | arg1Of | but,are |
R3294 | T4829 | T4834 | arg2Of | but,required |
R3295 | T4831 | T4829 | arg2Of | IKK1,but |
R3296 | T4834 | T4823 | arg2Of | required,showed |
R3297 | T4834 | T4824 | arg1Of | required,that |
R3298 | T4834 | T4832 | arg1Of | required,"," |
R3299 | T4834 | T4833 | arg2Of | required,are |
R3300 | T4834 | T4835 | arg1Of | required,for |
R3301 | T4834 | T4839 | arg1Of | required,[ |
R3302 | T4838 | T4835 | arg2Of | activation,for |
R3303 | T4838 | T4836 | arg1Of | activation,canonical |
R3304 | T4838 | T4837 | arg1Of | activation,NF-κB |
R3305 | T4840 | T4839 | arg2Of | 21,[ |
R3306 | T4841 | T4839 | arg3Of | ],[ |
R3307 | T4842 | T4843 | arg1Of | One,of |
R3308 | T4842 | T4850 | arg1Of | One,is |
R3309 | T4846 | T4845 | arg1Of | studied,best |
R3310 | T4849 | T4843 | arg2Of | pathways,of |
R3311 | T4849 | T4844 | arg1Of | pathways,the |
R3312 | T4849 | T4846 | arg1Of | pathways,studied |
R3313 | T4849 | T4847 | arg1Of | pathways,NF-κB |
R3314 | T4849 | T4848 | arg1Of | pathways,signalling |
R3315 | T4853 | T4850 | arg2Of | pathway,is |
R3316 | T4853 | T4851 | arg1Of | pathway,the |
R3317 | T4853 | T4852 | arg1Of | pathway,TNF |
R3318 | T4855 | T4854 | arg1Of | stimulation,TNF |
R3319 | T4855 | T4856 | arg1Of | stimulation,results |
R3320 | T4856 | T4857 | arg1Of | results,in |
R3321 | T4859 | T4860 | arg1Of | recruitment,of |
R3322 | T4859 | T4870 | arg1Of | recruitment,of |
R3323 | T4859 | T4878 | arg1Of | recruitment,"," |
R3324 | T4859 | T4879 | arg1Of | recruitment,which |
R3325 | T4859 | T4880 | arg1Of | recruitment,function |
R3326 | T4859 | T4896 | arg1Of | recruitment,and |
R3327 | T4860 | T4869 | arg1Of | of,and |
R3328 | T4864 | T4861 | arg1Of | domain,TNF |
R3329 | T4864 | T4862 | arg1Of | domain,receptor-1-associated |
R3330 | T4864 | T4863 | arg1Of | domain,death |
R3331 | T4864 | T4865 | arg1Of | domain,( |
R3332 | T4866 | T4865 | arg2Of | TRADD,( |
R3333 | T4867 | T4865 | arg3Of | ),( |
R3334 | T4868 | T4860 | arg2Of | protein,of |
R3335 | T4868 | T4864 | arg1Of | protein,domain |
R3336 | T4870 | T4869 | arg2Of | of,and |
R3337 | T4873 | T4870 | arg2Of | protein,of |
R3338 | T4873 | T4871 | arg1Of | protein,receptor |
R3339 | T4873 | T4872 | arg1Of | protein,interacting |
R3340 | T4873 | T4874 | arg1Of | protein,1 |
R3341 | T4873 | T4875 | arg1Of | protein,( |
R3342 | T4876 | T4875 | arg2Of | RIP1,( |
R3343 | T4877 | T4875 | arg3Of | ),( |
R3344 | T4880 | T4881 | arg1Of | function,as |
R3345 | T4883 | T4881 | arg2Of | proteins,as |
R3346 | T4883 | T4882 | arg1Of | proteins,adaptor |
R3347 | T4883 | T4884 | arg1Of | proteins,for |
R3348 | T4891 | T4884 | arg2Of | factor,for |
R3349 | T4891 | T4885 | arg1Of | factor,the |
R3350 | T4891 | T4886 | arg1Of | factor,E3 |
R3351 | T4891 | T4887 | arg1Of | factor,ubiquitin |
R3352 | T4891 | T4888 | arg1Of | factor,ligases |
R3353 | T4891 | T4889 | arg1Of | factor,TNF |
R3354 | T4891 | T4890 | arg1Of | factor,receptor-associated |
R3355 | T4891 | T4892 | arg1Of | factor,( |
R3356 | T4891 | T4895 | arg1Of | factor,2 |
R3357 | T4893 | T4892 | arg2Of | TRAF,( |
R3358 | T4894 | T4892 | arg3Of | ),( |
R3359 | T4896 | T4857 | arg2Of | and,in |
R3360 | T4896 | T4858 | arg1Of | and,the |
R3361 | T4897 | T4896 | arg2Of | TRAF5,and |
R3362 | T4897 | T4898 | arg1Of | TRAF5,"," |
R3363 | T4897 | T4899 | arg1Of | TRAF5,which |
R3364 | T4897 | T4902 | arg1Of | TRAF5,bind |
R3365 | T4901 | T4900 | arg2Of | turn,in |
R3366 | T4902 | T4900 | arg1Of | bind,in |
R3367 | T4908 | T4902 | arg2Of | inhibitor,bind |
R3368 | T4908 | T4903 | arg1Of | inhibitor,the |
R3369 | T4908 | T4904 | arg1Of | inhibitor,E3 |
R3370 | T4908 | T4905 | arg1Of | inhibitor,ubiquitin |
R3371 | T4908 | T4906 | arg1Of | inhibitor,ligases |
R3372 | T4908 | T4907 | arg1Of | inhibitor,cellular |
R3373 | T4908 | T4909 | arg1Of | inhibitor,of |
R3374 | T4910 | T4911 | arg1Of | apoptosis,( |
R3375 | T4910 | T4914 | arg1Of | apoptosis,1 |
R3376 | T4910 | T4915 | arg1Of | apoptosis,and |
R3377 | T4912 | T4911 | arg2Of | cIAP,( |
R3378 | T4913 | T4911 | arg3Of | ),( |
R3379 | T4915 | T4909 | arg2Of | and,of |
R3380 | T4916 | T4915 | arg2Of | cIAP2,and |
R3381 | T4916 | T4917 | arg1Of | cIAP2,( |
R3382 | T4918 | T4917 | arg2Of | Figure,( |
R3383 | T4918 | T4919 | arg1Of | Figure,1 |
R3384 | T4920 | T4917 | arg3Of | ),( |
R3385 | T4923 | T4921 | arg2Of | stimulation,On |
R3386 | T4923 | T4922 | arg1Of | stimulation,TNF |
R3387 | T4925 | T4926 | arg1Of | TNF-receptor,bound |
R3388 | T4926 | T4921 | arg1Of | bound,On |
R3389 | T4926 | T4924 | arg1Of | bound,"," |
R3390 | T4927 | T4928 | arg1Of | RIP1,is |
R3391 | T4927 | T4930 | arg2Of | RIP1,modified |
R3392 | T4930 | T4926 | arg2Of | modified,bound |
R3393 | T4930 | T4928 | arg2Of | modified,is |
R3394 | T4930 | T4929 | arg1Of | modified,rapidly |
R3395 | T4934 | T4930 | arg1Of | chains,modified |
R3396 | T4934 | T4931 | arg2Of | chains,by |
R3397 | T4934 | T4932 | arg1Of | chains,K63-linked |
R3398 | T4934 | T4933 | arg1Of | chains,polyubiquitin |
R3399 | T4935 | T4936 | arg1Of | TRAF2/5,and |
R3400 | T4936 | T4938 | arg1Of | and,are |
R3401 | T4937 | T4936 | arg2Of | cIAP1/2,and |
R3402 | T4938 | T4945 | arg1Of | are,but |
R3403 | T4940 | T4938 | arg2Of | candidates,are |
R3404 | T4940 | T4939 | arg1Of | candidates,good |
R3405 | T4940 | T4941 | arg1Of | candidates,for |
R3406 | T4943 | T4941 | arg2Of | ubiquitination,for |
R3407 | T4943 | T4942 | arg1Of | ubiquitination,RIP1 |
R3408 | T4945 | T4944 | arg1Of | but,"," |
R3409 | T4948 | T4946 | arg1Of | role,the |
R3410 | T4948 | T4947 | arg1Of | role,specific |
R3411 | T4948 | T4949 | arg1Of | role,of |
R3412 | T4948 | T4951 | arg1Of | role,is |
R3413 | T4948 | T4953 | arg1Of | role,unclear |
R3414 | T4950 | T4949 | arg2Of | each,of |
R3415 | T4951 | T4945 | arg2Of | is,but |
R3416 | T4951 | T4952 | arg1Of | is,still |
R3417 | T4953 | T4951 | arg2Of | unclear,is |
R3418 | T4956 | T4954 | arg1Of | chains,The |
R3419 | T4956 | T4955 | arg1Of | chains,polyubiquitin |
R3420 | T4956 | T4957 | arg1Of | chains,on |
R3421 | T4956 | T4959 | arg1Of | chains,are |
R3422 | T4956 | T4960 | arg2Of | chains,believed |
R3423 | T4956 | T4962 | arg1Of | chains,create |
R3424 | T4958 | T4957 | arg2Of | RIP1,on |
R3425 | T4960 | T4959 | arg2Of | believed,are |
R3426 | T4962 | T4960 | arg3Of | create,believed |
R3427 | T4962 | T4961 | arg1Of | create,to |
R3428 | T4964 | T4962 | arg2Of | scaffold,create |
R3429 | T4964 | T4963 | arg1Of | scaffold,a |
R3430 | T4964 | T4965 | modOf | scaffold,to |
R3431 | T4966 | T4965 | arg1Of | recruit,to |
R3432 | T4966 | T4979 | arg1Of | recruit,"," |
R3433 | T4966 | T4980 | arg1Of | recruit,respectively |
R3434 | T4968 | T4969 | arg1Of | IKK,and |
R3435 | T4970 | T4969 | arg2Of | TAK1,and |
R3436 | T4971 | T4966 | arg2Of | complex,recruit |
R3437 | T4971 | T4967 | arg1Of | complex,the |
R3438 | T4971 | T4968 | arg1Of | complex,IKK |
R3439 | T4971 | T4970 | arg1Of | complex,TAK1 |
R3440 | T4971 | T4972 | arg1Of | complex,via |
R3441 | T4975 | T4973 | arg1Of | proteins,the |
R3442 | T4975 | T4974 | arg1Of | proteins,ubiquitin-binding |
R3443 | T4976 | T4977 | arg1Of | NEMO,and |
R3444 | T4977 | T4972 | arg2Of | and,via |
R3445 | T4977 | T4975 | arg1Of | and,proteins |
R3446 | T4978 | T4977 | arg2Of | TAB1/2,and |
R3447 | T4983 | T4981 | arg1Of | identification,The |
R3448 | T4983 | T4982 | arg1Of | identification,recent |
R3449 | T4983 | T4984 | arg1Of | identification,of |
R3450 | T4983 | T5004 | arg1Of | identification,adds |
R3451 | T4989 | T4984 | arg2Of | complex,of |
R3452 | T4989 | T4985 | arg1Of | complex,a |
R3453 | T4989 | T4986 | arg1Of | complex,distinct |
R3454 | T4989 | T4987 | arg1Of | complex,E2/E3 |
R3455 | T4989 | T4988 | arg1Of | complex,enzyme |
R3456 | T4989 | T4990 | arg1Of | complex,that |
R3457 | T4989 | T4991 | arg1Of | complex,modifies |
R3458 | T4989 | T4998 | arg1Of | complex,is |
R3459 | T4989 | T4999 | arg1Of | complex,essential |
R3460 | T4991 | T4997 | arg1Of | modifies,and |
R3461 | T4992 | T4991 | arg2Of | NEMO,modifies |
R3462 | T4992 | T4993 | arg1Of | NEMO,with |
R3463 | T4996 | T4993 | arg2Of | chains,with |
R3464 | T4996 | T4994 | arg1Of | chains,linear |
R3465 | T4996 | T4995 | arg1Of | chains,polyubiquitin |
R3466 | T4998 | T4997 | arg2Of | is,and |
R3467 | T4999 | T4998 | arg2Of | essential,is |
R3468 | T4999 | T5000 | arg1Of | essential,for |
R3469 | T5003 | T5000 | arg2Of | signalling,for |
R3470 | T5003 | T5001 | arg1Of | signalling,TNF-activated |
R3471 | T5003 | T5002 | arg1Of | signalling,NF-κB |
R3472 | T5006 | T5004 | arg2Of | complexity,adds |
R3473 | T5006 | T5005 | arg1Of | complexity,further |
R3474 | T5006 | T5007 | arg1Of | complexity,[ |
R3475 | T5008 | T5007 | arg2Of | 22,[ |
R3476 | T5009 | T5007 | arg3Of | ],[ |
R3477 | T5012 | T5010 | arg1Of | role,The |
R3478 | T5012 | T5011 | arg1Of | role,exact |
R3479 | T5012 | T5013 | arg1Of | role,of |
R3480 | T5012 | T5017 | arg1Of | role,remains |
R3481 | T5012 | T5018 | arg1Of | role,unclear |
R3482 | T5016 | T5013 | arg2Of | chains,of |
R3483 | T5016 | T5014 | arg1Of | chains,protein-anchored |
R3484 | T5016 | T5015 | arg1Of | chains,polyubiquitin |
R3485 | T5017 | T5019 | arg1Of | remains,"," |
R3486 | T5017 | T5020 | arg1Of | remains,as |
R3487 | T5018 | T5017 | arg2Of | unclear,remains |
R3488 | T5021 | T5022 | arg1Of | it,was |
R3489 | T5021 | T5024 | arg2Of | it,suggested |
R3490 | T5024 | T5020 | arg2Of | suggested,as |
R3491 | T5024 | T5022 | arg2Of | suggested,was |
R3492 | T5024 | T5023 | arg1Of | suggested,recently |
R3493 | T5028 | T5026 | arg1Of | chains,unanchored |
R3494 | T5028 | T5027 | arg1Of | chains,polyubiquitin |
R3495 | T5028 | T5029 | arg1Of | chains,can |
R3496 | T5028 | T5031 | arg1Of | chains,activate |
R3497 | T5031 | T5024 | arg3Of | activate,suggested |
R3498 | T5031 | T5025 | arg1Of | activate,that |
R3499 | T5031 | T5029 | arg2Of | activate,can |
R3500 | T5031 | T5030 | arg1Of | activate,directly |
R3501 | T5031 | T5035 | arg1Of | activate,[ |
R3502 | T5034 | T5031 | arg2Of | complex,activate |
R3503 | T5034 | T5032 | arg1Of | complex,the |
R3504 | T5034 | T5033 | arg1Of | complex,TAK1 |
R3505 | T5036 | T5035 | arg2Of | 23,[ |
R3506 | T5037 | T5035 | arg3Of | ],[ |
R3507 | T5040 | T5038 | arg1Of | principles,Similar |
R3508 | T5040 | T5039 | arg1Of | principles,signalling |
R3509 | T5040 | T5041 | arg1Of | principles,apply |
R3510 | T5041 | T5042 | arg1Of | apply,to |
R3511 | T5044 | T5042 | arg2Of | receptors,to |
R3512 | T5044 | T5043 | arg1Of | receptors,other |
R3513 | T5046 | T5045 | arg2Of | example,For |
R3514 | T5049 | T5048 | arg1Of | stimulation,TLR4 |
R3515 | T5049 | T5050 | arg1Of | stimulation,by |
R3516 | T5049 | T5052 | arg1Of | stimulation,induces |
R3517 | T5051 | T5050 | arg2Of | lipopolysaccharide,by |
R3518 | T5052 | T5045 | arg1Of | induces,For |
R3519 | T5052 | T5047 | arg1Of | induces,"," |
R3520 | T5054 | T5052 | arg2Of | recruitment,induces |
R3521 | T5054 | T5053 | arg1Of | recruitment,the |
R3522 | T5054 | T5055 | arg1Of | recruitment,of |
R3523 | T5059 | T5056 | arg1Of | protein,Toll/IL-1 |
R3524 | T5059 | T5057 | arg1Of | protein,receptor |
R3525 | T5059 | T5058 | arg1Of | protein,adaptor |
R3526 | T5059 | T5060 | arg1Of | protein,( |
R3527 | T5059 | T5067 | arg1Of | protein,and |
R3528 | T5062 | T5060 | arg2Of | referred,( |
R3529 | T5062 | T5061 | arg1Of | referred,also |
R3530 | T5062 | T5063 | arg1Of | referred,to |
R3531 | T5062 | T5064 | arg1Of | referred,as |
R3532 | T5065 | T5064 | arg2Of | Mal,as |
R3533 | T5066 | T5060 | arg3Of | ),( |
R3534 | T5067 | T5055 | arg2Of | and,of |
R3535 | T5067 | T5074 | arg1Of | and,"," |
R3536 | T5067 | T5075 | arg1Of | and,which |
R3537 | T5067 | T5078 | arg1Of | and,serve |
R3538 | T5067 | T5080 | arg1Of | and,bridging |
R3539 | T5070 | T5067 | arg2Of | molecule,and |
R3540 | T5070 | T5068 | arg1Of | molecule,TRIF-related |
R3541 | T5070 | T5069 | arg1Of | molecule,adaptor |
R3542 | T5070 | T5071 | arg1Of | molecule,( |
R3543 | T5072 | T5071 | arg2Of | TRAM,( |
R3544 | T5073 | T5071 | arg3Of | ),( |
R3545 | T5077 | T5076 | arg1Of | probably,most |
R3546 | T5078 | T5077 | arg1Of | serve,probably |
R3547 | T5078 | T5079 | arg1Of | serve,as |
R3548 | T5080 | T5079 | arg2Of | bridging,as |
R3549 | T5081 | T5080 | arg2Of | factors,bridging |
R3550 | T5081 | T5083 | arg1Of | factors,recruit |
R3551 | T5083 | T5080 | arg3Of | recruit,bridging |
R3552 | T5083 | T5082 | arg1Of | recruit,to |
R3553 | T5083 | T5101 | arg1Of | recruit,"," |
R3554 | T5083 | T5102 | arg1Of | recruit,respectively |
R3555 | T5086 | T5084 | arg1Of | primary,myeloid |
R3556 | T5086 | T5085 | arg1Of | primary,differentiation |
R3557 | T5088 | T5087 | arg1Of | gene,response |
R3558 | T5088 | T5089 | arg1Of | gene,88 |
R3559 | T5088 | T5090 | arg1Of | gene,( |
R3560 | T5088 | T5093 | arg1Of | gene,and |
R3561 | T5091 | T5090 | arg2Of | MyD88,( |
R3562 | T5092 | T5090 | arg3Of | ),( |
R3563 | T5093 | T5083 | arg2Of | and,recruit |
R3564 | T5093 | T5086 | arg1Of | and,primary |
R3565 | T5097 | T5093 | arg2Of | IFNβ,and |
R3566 | T5097 | T5094 | arg1Of | IFNβ,TIR |
R3567 | T5097 | T5095 | arg1Of | IFNβ,domain-containing |
R3568 | T5097 | T5096 | arg1Of | IFNβ,adaptor-inducing |
R3569 | T5097 | T5098 | arg1Of | IFNβ,( |
R3570 | T5099 | T5098 | arg2Of | TRIF,( |
R3571 | T5100 | T5098 | arg3Of | ),( |
R3572 | T5103 | T5106 | arg1Of | MyD88,recruits |
R3573 | T5105 | T5104 | arg2Of | turn,in |
R3574 | T5106 | T5104 | arg1Of | recruits,in |
R3575 | T5106 | T5118 | arg1Of | recruits,"," |
R3576 | T5106 | T5119 | modOf | recruits,leading |
R3577 | T5106 | T5126 | arg1Of | recruits,[ |
R3578 | T5107 | T5106 | arg2Of | members,recruits |
R3579 | T5107 | T5108 | arg1Of | members,of |
R3580 | T5113 | T5112 | arg2Of | IRAK,( |
R3581 | T5114 | T5112 | arg3Of | ),( |
R3582 | T5115 | T5116 | arg1Of | family,and |
R3583 | T5116 | T5108 | arg2Of | and,of |
R3584 | T5116 | T5109 | arg1Of | and,the |
R3585 | T5116 | T5110 | arg1Of | and,IL-1R-associated |
R3586 | T5116 | T5111 | arg1Of | and,kinase |
R3587 | T5116 | T5112 | arg1Of | and,( |
R3588 | T5117 | T5116 | arg2Of | TRAF6,and |
R3589 | T5119 | T5120 | arg1Of | leading,to |
R3590 | T5121 | T5122 | arg1Of | oligomerisation,and |
R3591 | T5122 | T5120 | arg2Of | and,to |
R3592 | T5122 | T5124 | arg1Of | and,of |
R3593 | T5123 | T5122 | arg2Of | selfubiquitination,and |
R3594 | T5125 | T5124 | arg2Of | TRAF6,of |
R3595 | T5127 | T5126 | arg2Of | 24,[ |
R3596 | T5128 | T5126 | arg3Of | ],[ |
R3597 | T5129 | T5131 | arg1Of | TRIF,recruits |
R3598 | T5131 | T5130 | arg1Of | recruits,also |
R3599 | T5131 | T5141 | arg1Of | recruits,via |
R3600 | T5132 | T5133 | arg1Of | TRAF6,[ |
R3601 | T5132 | T5136 | arg1Of | TRAF6,and |
R3602 | T5134 | T5133 | arg2Of | 25,[ |
R3603 | T5135 | T5133 | arg3Of | ],[ |
R3604 | T5136 | T5131 | arg2Of | and,recruits |
R3605 | T5137 | T5136 | arg2Of | RIP1,and |
R3606 | T5137 | T5138 | arg1Of | RIP1,[ |
R3607 | T5139 | T5138 | arg2Of | 26,[ |
R3608 | T5140 | T5138 | arg3Of | ],[ |
R3609 | T5144 | T5141 | arg2Of | interaction,via |
R3610 | T5144 | T5142 | arg1Of | interaction,a |
R3611 | T5144 | T5143 | arg1Of | interaction,direct |
R3612 | T5146 | T5145 | arg1Of | pathways,Both |
R3613 | T5146 | T5148 | arg1Of | pathways,activate |
R3614 | T5148 | T5147 | arg1Of | activate,then |
R3615 | T5148 | T5152 | arg1Of | activate,in |
R3616 | T5149 | T5150 | arg1Of | TAK1,and |
R3617 | T5150 | T5148 | arg2Of | and,activate |
R3618 | T5151 | T5150 | arg2Of | IKK,and |
R3619 | T5155 | T5152 | arg2Of | manner,in |
R3620 | T5155 | T5153 | arg1Of | manner,a |
R3621 | T5155 | T5154 | arg1Of | manner,ubiquitination-dependent |
R3622 | T5155 | T5156 | arg1Of | manner,similar |
R3623 | T5156 | T5157 | arg1Of | similar,to |
R3624 | T5160 | T5157 | arg2Of | pathway,to |
R3625 | T5160 | T5158 | arg1Of | pathway,the |
R3626 | T5160 | T5159 | arg1Of | pathway,TNF |
R3627 | T5160 | T5161 | arg1Of | pathway,( |
R3628 | T5162 | T5161 | arg2Of | Figure,( |
R3629 | T5162 | T5163 | arg1Of | Figure,1 |
R3630 | T5164 | T5161 | arg3Of | ),( |
R3631 | T5168 | T5165 | arg1Of | pathway,The |
R3632 | T5168 | T5166 | arg1Of | pathway,noncanonical |
R3633 | T5168 | T5167 | arg1Of | pathway,NF-κB |
R3634 | T5168 | T5169 | arg1Of | pathway,can |
R3635 | T5168 | T5170 | arg1Of | pathway,be |
R3636 | T5168 | T5171 | arg2Of | pathway,activated |
R3637 | T5171 | T5169 | arg2Of | activated,can |
R3638 | T5171 | T5170 | arg2Of | activated,be |
R3639 | T5171 | T5172 | arg1Of | activated,by |
R3640 | T5176 | T5173 | arg1Of | receptor,the |
R3641 | T5176 | T5174 | arg1Of | receptor,lymphotoxin |
R3642 | T5176 | T5175 | arg1Of | receptor,β |
R3643 | T5176 | T5177 | arg1Of | receptor,"," |
R3644 | T5176 | T5180 | arg1Of | receptor,"," |
R3645 | T5179 | T5177 | arg2Of | receptor,"," |
R3646 | T5179 | T5178 | arg1Of | receptor,BAFF |
R3647 | T5180 | T5183 | arg1Of | ",",and |
R3648 | T5181 | T5180 | arg2Of | CD40,"," |
R3649 | T5183 | T5172 | arg2Of | and,by |
R3650 | T5183 | T5182 | arg1Of | and,"," |
R3651 | T5184 | T5183 | arg2Of | RANK,and |
R3652 | T5184 | T5185 | arg1Of | RANK,( |
R3653 | T5186 | T5185 | arg2Of | Figure,( |
R3654 | T5186 | T5187 | arg1Of | Figure,2 |
R3655 | T5188 | T5185 | arg3Of | ),( |
R3656 | T5191 | T5189 | arg2Of | pathway,In |
R3657 | T5191 | T5190 | arg1Of | pathway,this |
R3658 | T5193 | T5194 | arg1Of | p100,is |
R3659 | T5193 | T5195 | arg2Of | p100,processed |
R3660 | T5195 | T5194 | arg2Of | processed,is |
R3661 | T5195 | T5226 | arg1Of | processed,and |
R3662 | T5198 | T5199 | arg1Of | proteasome,to |
R3663 | T5198 | T5201 | arg1Of | proteasome,"," |
R3664 | T5198 | T5202 | arg1Of | proteasome,which |
R3665 | T5198 | T5209 | arg1Of | proteasome,regulates |
R3666 | T5198 | T5220 | arg1Of | proteasome,"," |
R3667 | T5200 | T5199 | arg2Of | p52,to |
R3668 | T5203 | T5204 | arg1Of | together,with |
R3669 | T5208 | T5204 | arg2Of | subunit,with |
R3670 | T5208 | T5205 | arg1Of | subunit,the |
R3671 | T5208 | T5206 | arg1Of | subunit,RelB |
R3672 | T5208 | T5207 | arg1Of | subunit,NF-κB |
R3673 | T5209 | T5203 | arg1Of | regulates,together |
R3674 | T5212 | T5209 | arg2Of | set,regulates |
R3675 | T5212 | T5210 | arg1Of | set,a |
R3676 | T5212 | T5211 | arg1Of | set,distinct |
R3677 | T5212 | T5213 | arg1Of | set,of |
R3678 | T5215 | T5213 | arg2Of | genes,of |
R3679 | T5215 | T5214 | arg1Of | genes,target |
R3680 | T5215 | T5216 | arg1Of | genes,that |
R3681 | T5215 | T5217 | arg1Of | genes,control |
R3682 | T5219 | T5217 | arg2Of | development,control |
R3683 | T5219 | T5218 | arg1Of | development,B-cell |
R3684 | T5220 | T5195 | arg1Of | ",",processed |
R3685 | T5220 | T5196 | arg2Of | ",",by |
R3686 | T5220 | T5197 | arg1Of | ",",the |
R3687 | T5224 | T5220 | arg2Of | development,"," |
R3688 | T5224 | T5221 | arg1Of | development,secondary |
R3689 | T5224 | T5222 | arg1Of | development,lymphoid |
R3690 | T5224 | T5223 | arg1Of | development,organ |
R3691 | T5226 | T5189 | arg1Of | and,In |
R3692 | T5226 | T5192 | arg1Of | and,"," |
R3693 | T5226 | T5225 | arg1Of | and,"," |
R3694 | T5229 | T5228 | arg2Of | 27,[ |
R3695 | T5230 | T5228 | arg3Of | ],[ |
R3696 | T5232 | T5231 | arg1Of | noncanonical,The |
R3697 | T5234 | T5227 | arg1Of | pathway,osteoclastogenesis |
R3698 | T5234 | T5228 | arg1Of | pathway,[ |
R3699 | T5234 | T5232 | arg1Of | pathway,noncanonical |
R3700 | T5234 | T5233 | arg1Of | pathway,NF-κB |
R3701 | T5234 | T5235 | arg1Of | pathway,is |
R3702 | T5234 | T5237 | arg1Of | pathway,dependent |
R3703 | T5235 | T5226 | arg2Of | is,and |
R3704 | T5237 | T5235 | arg2Of | dependent,is |
R3705 | T5237 | T5236 | arg1Of | dependent,strictly |
R3706 | T5237 | T5238 | arg1Of | dependent,on |
R3707 | T5239 | T5238 | arg2Of | IKK1,on |
R3708 | T5239 | T5240 | arg1Of | IKK1,"," |
R3709 | T5239 | T5241 | arg1Of | IKK1,which |
R3710 | T5239 | T5242 | arg1Of | IKK1,is |
R3711 | T5239 | T5243 | arg2Of | IKK1,activated |
R3712 | T5243 | T5242 | arg2Of | activated,is |
R3713 | T5243 | T5244 | arg1Of | activated,upon |
R3714 | T5245 | T5244 | arg2Of | phosphorylation,upon |
R3715 | T5245 | T5246 | arg1Of | phosphorylation,by |
R3716 | T5247 | T5246 | arg2Of | NF-κB,by |
R3717 | T5247 | T5248 | arg1Of | NF-κB,inducing |
R3718 | T5249 | T5248 | arg2Of | kinase,inducing |
R3719 | T5249 | T5250 | arg1Of | kinase,( |
R3720 | T5251 | T5250 | arg2Of | NIK,( |
R3721 | T5252 | T5250 | arg3Of | ),( |
R3722 | T5253 | T5254 | arg1Of | NIK,is |
R3723 | T5253 | T5256 | arg2Of | NIK,regulated |
R3724 | T5253 | T5262 | arg1Of | NIK,is |
R3725 | T5253 | T5263 | arg1Of | NIK,present |
R3726 | T5256 | T5254 | arg2Of | regulated,is |
R3727 | T5256 | T5255 | arg1Of | regulated,predominantly |
R3728 | T5256 | T5257 | arg1Of | regulated,at |
R3729 | T5256 | T5261 | arg1Of | regulated,and |
R3730 | T5260 | T5257 | arg2Of | level,at |
R3731 | T5260 | T5258 | arg1Of | level,the |
R3732 | T5260 | T5259 | arg1Of | level,post-translational |
R3733 | T5262 | T5261 | arg2Of | is,and |
R3734 | T5263 | T5262 | arg2Of | present,is |
R3735 | T5263 | T5264 | arg1Of | present,at |
R3736 | T5263 | T5268 | arg1Of | present,in |
R3737 | T5266 | T5265 | arg1Of | low,extremely |
R3738 | T5267 | T5264 | arg2Of | levels,at |
R3739 | T5267 | T5266 | arg1Of | levels,low |
R3740 | T5271 | T5268 | arg2Of | types,in |
R3741 | T5271 | T5269 | arg1Of | types,most |
R3742 | T5271 | T5270 | arg1Of | types,cell |
R3743 | T5274 | T5272 | arg2Of | cells,In |
R3744 | T5274 | T5273 | arg1Of | cells,unstimulated |
R3745 | T5276 | T5277 | arg1Of | NIK,occurs |
R3746 | T5277 | T5272 | arg1Of | occurs,In |
R3747 | T5277 | T5275 | arg1Of | occurs,"," |
R3748 | T5277 | T5278 | arg1Of | occurs,in |
R3749 | T5277 | T5293 | arg1Of | occurs,"," |
R3750 | T5277 | T5294 | modOf | occurs,leading |
R3751 | T5281 | T5278 | arg2Of | complex,in |
R3752 | T5281 | T5279 | arg1Of | complex,a |
R3753 | T5281 | T5280 | arg1Of | complex,cytoplasmic |
R3754 | T5281 | T5282 | arg1Of | complex,with |
R3755 | T5283 | T5284 | arg1Of | TRAF2,"," |
R3756 | T5284 | T5287 | arg1Of | ",",and |
R3757 | T5285 | T5284 | arg2Of | TRAF3,"," |
R3758 | T5287 | T5282 | arg2Of | and,with |
R3759 | T5287 | T5286 | arg1Of | and,"," |
R3760 | T5287 | T5289 | arg1Of | and,"," |
R3761 | T5287 | T5290 | arg1Of | and,which |
R3762 | T5287 | T5291 | arg1Of | and,K48-polyubiquitinates |
R3763 | T5288 | T5287 | arg2Of | cIAP1/2,and |
R3764 | T5292 | T5291 | arg2Of | NIK,K48-polyubiquitinates |
R3765 | T5294 | T5295 | arg1Of | leading,to |
R3766 | T5298 | T5295 | arg2Of | degradation,to |
R3767 | T5298 | T5296 | arg1Of | degradation,its |
R3768 | T5298 | T5297 | arg1Of | degradation,continuous |
R3769 | T5298 | T5299 | arg1Of | degradation,by |
R3770 | T5301 | T5299 | arg2Of | proteasome,by |
R3771 | T5301 | T5300 | arg1Of | proteasome,the |
R3772 | T5303 | T5302 | arg1Of | ligation,Receptor |
R3773 | T5303 | T5304 | arg1Of | ligation,has |
R3774 | T5303 | T5305 | arg1Of | ligation,been |
R3775 | T5303 | T5306 | arg2Of | ligation,shown |
R3776 | T5306 | T5304 | arg2Of | shown,has |
R3777 | T5306 | T5305 | arg2Of | shown,been |
R3778 | T5306 | T5309 | modOf | shown,to |
R3779 | T5306 | T5324 | modOf | shown,to |
R3780 | T5308 | T5307 | arg1Of | only,not |
R3781 | T5310 | T5309 | arg1Of | remove,to |
R3782 | T5310 | T5315 | arg1Of | remove,by |
R3783 | T5310 | T5322 | arg1Of | remove,but |
R3784 | T5311 | T5310 | arg2Of | TRAF3,remove |
R3785 | T5311 | T5312 | arg1Of | TRAF3,from |
R3786 | T5314 | T5312 | arg2Of | complex,from |
R3787 | T5314 | T5313 | arg1Of | complex,this |
R3788 | T5316 | T5315 | arg2Of | recruiting,by |
R3789 | T5316 | T5318 | arg1Of | recruiting,to |
R3790 | T5317 | T5316 | arg2Of | it,recruiting |
R3791 | T5320 | T5318 | arg2Of | receptor,to |
R3792 | T5320 | T5319 | arg1Of | receptor,the |
R3793 | T5322 | T5308 | arg1Of | but,only |
R3794 | T5322 | T5321 | arg1Of | but,"," |
R3795 | T5322 | T5323 | arg1Of | but,also |
R3796 | T5325 | T5322 | arg2Of | attract,but |
R3797 | T5325 | T5324 | arg1Of | attract,to |
R3798 | T5326 | T5327 | arg1Of | TRAF2,and |
R3799 | T5327 | T5325 | arg2Of | and,attract |
R3800 | T5327 | T5329 | arg1Of | and,"," |
R3801 | T5327 | T5330 | arg1Of | and,which |
R3802 | T5327 | T5331 | arg1Of | and,are |
R3803 | T5327 | T5332 | arg1Of | and,essential |
R3804 | T5328 | T5327 | arg2Of | cIAP1/2,and |
R3805 | T5332 | T5331 | arg2Of | essential,are |
R3806 | T5332 | T5333 | arg1Of | essential,for |
R3807 | T5336 | T5333 | arg2Of | degradation,for |
R3808 | T5336 | T5334 | arg1Of | degradation,subsequent |
R3809 | T5336 | T5335 | arg1Of | degradation,TRAF3 |
R3810 | T5338 | T5337 | arg1Of | this,All |
R3811 | T5338 | T5339 | arg1Of | this,contributes |
R3812 | T5339 | T5340 | arg1Of | contributes,to |
R3813 | T5341 | T5340 | arg2Of | releasing,to |
R3814 | T5341 | T5343 | arg1Of | releasing,from |
R3815 | T5341 | T5347 | arg1Of | releasing,"," |
R3816 | T5341 | T5348 | modOf | releasing,resulting |
R3817 | T5341 | T5355 | arg1Of | releasing,[ |
R3818 | T5341 | T5358 | arg1Of | releasing,( |
R3819 | T5342 | T5341 | arg2Of | NIK,releasing |
R3820 | T5346 | T5343 | arg2Of | degradation,from |
R3821 | T5346 | T5344 | arg1Of | degradation,its |
R3822 | T5346 | T5345 | arg1Of | degradation,constitutive |
R3823 | T5348 | T5349 | arg1Of | resulting,in |
R3824 | T5351 | T5350 | arg1Of | accumulation,NIK |
R3825 | T5351 | T5352 | arg1Of | accumulation,and |
R3826 | T5352 | T5349 | arg2Of | and,in |
R3827 | T5389 | T5387 | arg2Of | ligand,of |
R3828 | T5389 | T5388 | arg1Of | ligand,their |
R3829 | T5354 | T5352 | arg2Of | phosphorylation,and |
R3830 | T5391 | T5392 | arg1Of | CD40,and |
R3831 | T5354 | T5353 | arg1Of | phosphorylation,IKK1 |
R3832 | T5392 | T5394 | arg1Of | and,interact |
R3833 | T5393 | T5392 | arg2Of | RANK,and |
R3834 | T5356 | T5355 | arg2Of | "28,29",[ |
R3835 | T5394 | T5395 | arg1Of | interact,with |
R3836 | T5357 | T5355 | arg3Of | ],[ |
R3837 | T5394 | T5412 | arg1Of | interact,and |
R3838 | T5359 | T5358 | arg2Of | Figure,( |
R3839 | T5398 | T5395 | arg2Of | members,with |
R3840 | T5398 | T5396 | arg1Of | members,several |
R3841 | T5398 | T5397 | arg1Of | members,TRAF |
R3842 | T5398 | T5399 | arg1Of | members,"," |
R3843 | T5398 | T5400 | arg1Of | members,including |
R3844 | T5401 | T5402 | arg1Of | TRAF1,"," |
R3845 | T5402 | T5404 | arg1Of | ",","," |
R3846 | T5403 | T5402 | arg2Of | TRAF2,"," |
R3847 | T5359 | T5360 | arg1Of | Figure,2 |
R3848 | T5404 | T5406 | arg1Of | ",","," |
R3849 | T5361 | T5358 | arg3Of | ),( |
R3850 | T5405 | T5404 | arg2Of | TRAF3,"," |
R3851 | T5406 | T5409 | arg1Of | ",",and |
R3852 | T5407 | T5406 | arg2Of | TRAF5,"," |
R3853 | T5362 | T5363 | arg1Of | It,should |
R3854 | T5409 | T5400 | arg2Of | and,including |
R3855 | T5409 | T5408 | arg1Of | and,"," |
R3856 | T5410 | T5409 | arg2Of | TRAF6,and |
R3857 | T5362 | T5364 | arg1Of | It,be |
R3858 | T5412 | T5385 | arg1Of | and,Upon |
R3859 | T5412 | T5390 | arg1Of | and,"," |
R3860 | T5412 | T5411 | arg1Of | and,"," |
R3861 | T5364 | T5363 | arg2Of | be,should |
R3862 | T5413 | T5414 | arg1Of | this,leads |
R3863 | T5414 | T5412 | arg2Of | leads,and |
R3864 | T5414 | T5415 | arg1Of | leads,to |
R3865 | T5367 | T5364 | arg2Of | CD40,be |
R3866 | T5417 | T5415 | arg2Of | proteolysis,to |
R3867 | T5417 | T5416 | arg1Of | proteolysis,the |
R3868 | T5417 | T5418 | arg1Of | proteolysis,of |
R3869 | T5417 | T5423 | arg1Of | proteolysis,"," |
R3870 | T5417 | T5424 | arg1Of | proteolysis,which |
R3871 | T5417 | T5425 | arg1Of | proteolysis,represents |
R3872 | T5420 | T5421 | arg1Of | TRAF2,and |
R3873 | T5421 | T5418 | arg2Of | and,of |
R3874 | T5421 | T5419 | arg1Of | and,both |
R3875 | T5422 | T5421 | arg2Of | TRAF3,and |
R3876 | T5367 | T5365 | arg2Of | CD40,mentioned |
R3877 | T5425 | T5436 | arg1Of | represents,as |
R3878 | T5367 | T5366 | arg1Of | CD40,that |
R3879 | T5371 | T5372 | arg1Of | receptor,and |
R3880 | T5428 | T5425 | arg2Of | step,represents |
R3881 | T5428 | T5426 | arg1Of | step,an |
R3882 | T5428 | T5427 | arg1Of | step,important |
R3883 | T5428 | T5429 | arg1Of | step,in |
R3884 | T5372 | T5369 | arg1Of | and,lymphotoxin |
R3885 | T5372 | T5370 | arg1Of | and,β |
R3891 | T5435 | T5433 | arg1Of | pathway,the |
R3892 | T5435 | T5434 | arg1Of | pathway,noncanonical |
R3893 | T5373 | T5372 | arg2Of | RANK,and |
R3894 | T5437 | T5436 | arg2Of | described,as |
R3895 | T5437 | T5438 | arg1Of | described,above |
R3896 | T5374 | T5363 | modOf | mediate,should |
R3897 | T5441 | T5439 | arg1Of | molecules,Specific |
R3898 | T5441 | T5440 | arg1Of | molecules,TRAF |
R3899 | T5441 | T5442 | arg1Of | molecules,are |
R3900 | T5441 | T5443 | arg2Of | molecules,associated |
R3901 | T5443 | T5442 | arg2Of | associated,are |
R3902 | T5443 | T5444 | arg1Of | associated,with |
R3903 | T5374 | T5368 | arg1Of | mediate,"," |
R3904 | T5376 | T5374 | arg2Of | activation,mediate |
R3905 | T5376 | T5375 | arg1Of | activation,the |
R3906 | T5449 | T5444 | arg2Of | functions,with |
R3907 | T5449 | T5445 | arg1Of | functions,overlapping |
R3908 | T5449 | T5446 | arg1Of | functions,and |
R3909 | T5449 | T5447 | arg1Of | functions,distinct |
R3910 | T5449 | T5448 | arg1Of | functions,CD40-mediated |
R3911 | T5376 | T5377 | arg1Of | activation,of |
R3912 | T5451 | T5450 | arg2Of | example,For |
R3913 | T5379 | T5380 | arg1Of | canonical,and |
R3914 | T5455 | T5453 | arg2Of | cells,in |
R3915 | T5455 | T5454 | arg1Of | cells,B |
R3916 | T5456 | T5457 | arg1Of | TRAF6,is |
R3917 | T5456 | T5458 | arg2Of | TRAF6,required |
R3918 | T5380 | T5378 | arg1Of | and,both |
R3919 | T5458 | T5457 | arg2Of | required,is |
R3920 | T5458 | T5459 | arg1Of | required,for |
R3921 | T5458 | T5466 | arg1Of | required,"," |
R3922 | T5458 | T5467 | arg1Of | required,while |
R3923 | T5458 | T5476 | arg1Of | required,and |
R3924 | T5381 | T5380 | arg2Of | noncanonical,and |
R3925 | T5462 | T5460 | arg1Of | activation,CD40-mediated |
R3926 | T5462 | T5461 | arg1Of | activation,JNK |
R3927 | T5462 | T5463 | arg1Of | activation,and |
R3928 | T5463 | T5459 | arg2Of | and,for |
R3929 | T5384 | T5377 | arg2Of | pathways,of |
R3930 | T5465 | T5463 | arg2Of | production,and |
R3931 | T5465 | T5464 | arg1Of | production,IL-6 |
R3932 | T5468 | T5469 | arg1Of | TRAF2,is |
R3933 | T5468 | T5470 | arg2Of | TRAF2,required |
R3934 | T5470 | T5467 | arg2Of | required,while |
R3935 | T5470 | T5469 | arg2Of | required,is |
R3936 | T5470 | T5471 | arg1Of | required,for |
R3937 | T5384 | T5379 | arg1Of | pathways,canonical |
R3938 | T5472 | T5471 | arg2Of | activation,for |
R3939 | T5472 | T5473 | arg1Of | activation,of |
R3940 | T5474 | T5473 | arg2Of | NF-κB,of |
R3941 | T5476 | T5450 | arg1Of | and,For |
R3942 | T5476 | T5452 | arg1Of | and,"," |
R3943 | T5476 | T5453 | arg1Of | and,in |
R3944 | T5476 | T5475 | arg1Of | and,"," |
R3945 | T5477 | T5478 | arg1Of | TRAF3,serves |
R3946 | T5384 | T5381 | arg1Of | pathways,noncanonical |
R3947 | T5478 | T5476 | arg2Of | serves,and |
R3948 | T5478 | T5479 | arg1Of | serves,as |
R3949 | T5384 | T5382 | arg1Of | pathways,NF-κB |
R3950 | T5384 | T5383 | arg1Of | pathways,signalling |
R3951 | T5386 | T5385 | arg2Of | binding,Upon |
R3952 | T5478 | T5486 | arg1Of | serves,[ |
R3953 | T5386 | T5387 | arg1Of | binding,of |
R3954 | T5485 | T5483 | arg2Of | signalling,of |
R3955 | T5482 | T5479 | arg2Of | regulator,as |
R3956 | T5482 | T5480 | arg1Of | regulator,a |
R3957 | T5482 | T5481 | arg1Of | regulator,negative |
R3958 | T5482 | T5483 | arg1Of | regulator,of |
R3959 | T5485 | T5484 | arg1Of | signalling,CD40 |
R3960 | T5487 | T5486 | arg2Of | "30,31",[ |
R3961 | T5488 | T5486 | arg3Of | ],[ |
R5593 | T8428 | T8427 | arg1Of | activation,NF-κB |
R5594 | T8428 | T8429 | arg1Of | activation,is |
R5595 | T8428 | T8431 | arg1Of | activation,crucial |
R5596 | T8429 | T8426 | arg2Of | is,Since |
R5597 | T8431 | T8429 | arg2Of | crucial,is |
R5598 | T8431 | T8430 | arg1Of | crucial,so |
R5599 | T8431 | T8432 | arg1Of | crucial,to |
R5600 | T8435 | T8432 | arg2Of | processes,to |
R5601 | T8435 | T8433 | arg1Of | processes,many |
R5602 | T8435 | T8434 | arg1Of | processes,cellular |
R5603 | T8439 | T8437 | arg1Of | regulation,a |
R5604 | T8439 | T8438 | arg1Of | regulation,tight |
R5605 | T8439 | T8440 | arg1Of | regulation,of |
R5606 | T8439 | T8445 | arg1Of | regulation,and |
R5607 | T8444 | T8440 | arg2Of | pathway,of |
R5608 | T8444 | T8441 | arg1Of | pathway,the |
R5609 | T8444 | T8442 | arg1Of | pathway,NF-κB |
R5610 | T8444 | T8443 | arg1Of | pathway,signalling |
R5611 | T8445 | T8450 | arg1Of | and,is |
R5612 | T8447 | T8445 | arg2Of | genes,and |
R5613 | T8447 | T8446 | arg1Of | genes,the |
R5614 | T8447 | T8449 | arg2Of | genes,induces |
R5615 | T8448 | T8449 | arg1Of | it,induces |
R5616 | T8450 | T8426 | arg1Of | is,Since |
R5617 | T8450 | T8436 | arg1Of | is,"," |
R5618 | T8453 | T8450 | arg2Of | requirement,is |
R5619 | T8453 | T8451 | arg1Of | requirement,an |
R5620 | T8453 | T8452 | arg1Of | requirement,absolute |
R5621 | T8453 | T8454 | modOf | requirement,to |
R5622 | T8453 | T8455 | arg1Of | requirement,fine-tune |
R5623 | T8455 | T8454 | arg1Of | fine-tune,to |
R5624 | T8458 | T8455 | arg2Of | response,fine-tune |
R5625 | T8458 | T8456 | arg1Of | response,the |
R5626 | T8458 | T8457 | arg1Of | response,inflammatory |
R5627 | T8461 | T8465 | arg1Of | terminating,is |
R5628 | T8461 | T8466 | arg1Of | terminating,essential |
R5629 | T8464 | T8461 | arg2Of | response,terminating |
R5630 | T8464 | T8462 | arg1Of | response,an |
R5631 | T8464 | T8463 | arg1Of | response,NF-κB |
R5632 | T8465 | T8459 | arg1Of | is,Moreover |
R5633 | T8465 | T8460 | arg1Of | is,"," |
R5634 | T8466 | T8465 | arg2Of | essential,is |
R5635 | T8468 | T8466 | arg2Of | prevent,essential |
R5636 | T8468 | T8467 | arg1Of | prevent,to |
R5637 | T8471 | T8468 | arg2Of | activation,prevent |
R5638 | T8471 | T8469 | arg1Of | activation,persistent |
R5639 | T8471 | T8470 | arg1Of | activation,NF-κB |
R5640 | T8471 | T8472 | arg1Of | activation,that |
R5641 | T8471 | T8473 | arg1Of | activation,may |
R5642 | T8471 | T8474 | arg1Of | activation,lead |
R5643 | T8474 | T8473 | arg2Of | lead,may |
R5644 | T8474 | T8475 | arg1Of | lead,to |
R5645 | T8477 | T8478 | arg1Of | inflammation,and/or |
R5646 | T8478 | T8475 | arg2Of | and/or,to |
R5647 | T8478 | T8476 | arg1Of | and/or,chronic |
R5648 | T8479 | T8478 | arg2Of | tumorigenesis,and/or |
R5649 | T8481 | T8480 | arg1Of | achieve,To |
R5650 | T8482 | T8481 | arg2Of | this,achieve |
R5651 | T8484 | T8481 | arg1Of | cells,achieve |
R5652 | T8484 | T8485 | arg1Of | cells,employ |
R5653 | T8485 | T8480 | modOf | employ,To |
R5654 | T8485 | T8483 | arg1Of | employ,"," |
R5655 | T8487 | T8485 | arg2Of | mechanisms,employ |
R5656 | T8487 | T8486 | arg1Of | mechanisms,different |
R5657 | T8487 | T8488 | arg1Of | mechanisms,"," |
R5658 | T8487 | T8489 | arg1Of | mechanisms,including |
R5659 | T8491 | T8489 | arg2Of | expression,including |
R5660 | T8491 | T8490 | arg1Of | expression,the |
R5661 | T8491 | T8492 | arg1Of | expression,of |
R5662 | T8494 | T8492 | arg2Of | proteins,of |
R5663 | T8494 | T8493 | arg1Of | proteins,inhibitory |
R5664 | T8494 | T8495 | arg1Of | proteins,that |
R5665 | T8494 | T8496 | arg1Of | proteins,downregulate |
R5666 | T8496 | T8499 | arg1Of | downregulate,[ |
R5667 | T8498 | T8496 | arg2Of | signalling,downregulate |
R5668 | T8498 | T8497 | arg1Of | signalling,NF-κB |
R5669 | T8500 | T8499 | arg2Of | 32,[ |
R5670 | T8501 | T8499 | arg3Of | ],[ |
R5671 | T8503 | T8504 | arg1Of | we,give |
R5672 | T8504 | T8524 | arg1Of | give,"," |
R5673 | T8506 | T8504 | arg2Of | overview,give |
R5674 | T8506 | T8505 | arg1Of | overview,an |
R5675 | T8506 | T8507 | arg1Of | overview,of |
R5676 | T8509 | T8507 | arg2Of | number,of |
R5677 | T8509 | T8508 | arg1Of | number,a |
R5678 | T8509 | T8510 | arg1Of | number,of |
R5679 | T8511 | T8510 | arg2Of | proteins,of |
R5680 | T8511 | T8512 | arg1Of | proteins,that |
R5681 | T8511 | T8513 | arg1Of | proteins,are |
R5682 | T8511 | T8514 | arg2Of | proteins,involved |
R5683 | T8514 | T8513 | arg2Of | involved,are |
R5684 | T8514 | T8515 | arg1Of | involved,in |
R5685 | T8517 | T8518 | arg1Of | dampening,or |
R5686 | T8518 | T8515 | arg2Of | or,in |
R5687 | T8518 | T8516 | arg1Of | or,the |
R5688 | T8518 | T8520 | arg1Of | or,of |
R5689 | T8519 | T8518 | arg2Of | termination,or |
R5690 | T8523 | T8520 | arg2Of | response,of |
R5691 | T8523 | T8521 | arg1Of | response,the |
R5692 | T8523 | T8522 | arg1Of | response,NF-κB |
R5693 | T8525 | T8504 | arg3Of | some,give |
R5694 | T8525 | T8526 | arg1Of | some,of |
R5695 | T8527 | T8526 | arg2Of | them,of |
R5696 | T8530 | T8528 | arg2Of | control,under |
R5697 | T8530 | T8529 | arg1Of | control,the |
R5698 | T8530 | T8531 | arg1Of | control,of |
R5699 | T8533 | T8531 | arg2Of | itself,of |
R5700 | T8533 | T8532 | arg1Of | itself,NF-κB |
R5701 | T8536 | T8534 | arg2Of | acting,and |
R5702 | T8536 | T8535 | arg1Of | acting,thus |
R5703 | T8536 | T8537 | arg1Of | acting,in |
R5704 | T8541 | T8537 | arg2Of | loop,in |
R5705 | T8541 | T8538 | arg1Of | loop,a |
R5706 | T8541 | T8539 | arg1Of | loop,negative |
R5707 | T8541 | T8540 | arg1Of | loop,feedback |
R5708 | T8543 | T8542 | arg2Of | addition,In |
R5709 | T8545 | T8546 | arg1Of | we,discuss |
R5710 | T8546 | T8542 | arg1Of | discuss,In |
R5711 | T8546 | T8544 | arg1Of | discuss,"," |
R5712 | T8549 | T8546 | arg2Of | role,discuss |
R5713 | T8549 | T8547 | arg1Of | role,the |
R5714 | T8549 | T8548 | arg1Of | role,potential |
R5715 | T8549 | T8550 | arg1Of | role,of |
R5716 | T8549 | T8555 | arg1Of | role,in |
R5717 | T8554 | T8550 | arg2Of | factors,of |
R5718 | T8554 | T8551 | arg1Of | factors,these |
R5719 | T8554 | T8552 | arg1Of | factors,NF-κB |
R5720 | T8554 | T8553 | arg1Of | factors,inhibitory |
R5721 | T8557 | T8555 | arg2Of | immunopathology,in |
R5722 | T8557 | T8556 | arg1Of | immunopathology,the |
R5723 | T8557 | T8558 | arg1Of | immunopathology,of |
R5724 | T8559 | T8558 | arg2Of | RA,of |
R5725 | T8562 | T8560 | arg1Of | proteins,Several |
R5726 | T8562 | T8561 | arg1Of | proteins,other |
R5727 | T8562 | T8563 | arg2Of | proteins,involved |
R5728 | T8562 | T8572 | arg1Of | proteins,"," |
R5729 | T8562 | T8574 | arg1Of | proteins,as |
R5730 | T8562 | T8582 | arg1Of | proteins,have |
R5731 | T8562 | T8583 | arg1Of | proteins,been |
R5732 | T8562 | T8584 | arg2Of | proteins,described |
R5733 | T8563 | T8564 | arg1Of | involved,in |
R5734 | T8567 | T8564 | arg2Of | regulation,in |
R5735 | T8567 | T8565 | arg1Of | regulation,the |
R5736 | T8567 | T8566 | arg1Of | regulation,negative |
R5737 | T8567 | T8568 | arg1Of | regulation,of |
R5738 | T8571 | T8568 | arg2Of | responses,of |
R5739 | T8571 | T8569 | arg1Of | responses,NF-κB-dependent |
R5740 | T8571 | T8570 | arg1Of | responses,inflammatory |
R5741 | T8574 | T8573 | arg1Of | as,such |
R5742 | T8575 | T8576 | arg1Of | MyD88s,"," |
R5743 | T8576 | T8579 | arg1Of | ",",and |
R5744 | T8577 | T8576 | arg2Of | IRAK-M,"," |
R5745 | T8579 | T8574 | arg2Of | and,as |
R5746 | T8579 | T8578 | arg1Of | and,"," |
R5747 | T8580 | T8579 | arg2Of | TOLLIP,and |
R5748 | T8584 | T8581 | arg1Of | described,"," |
R5749 | T8584 | T8582 | arg2Of | described,have |
R5750 | T8584 | T8583 | arg2Of | described,been |
R5751 | T8584 | T8585 | arg1Of | described,( |
R5752 | T8586 | T8585 | arg2Of | reviewed,( |
R5753 | T8586 | T8587 | arg1Of | reviewed,in |
R5754 | T8586 | T8588 | arg1Of | reviewed,[ |
R5755 | T8589 | T8588 | arg2Of | 33,[ |
R5756 | T8590 | T8588 | arg3Of | ],[ |
R5757 | T8591 | T8585 | arg3Of | ),( |
R5758 | T8593 | T8592 | arg1Of | proteins,These |
R5759 | T8593 | T8594 | arg1Of | proteins,are |
R5760 | T8593 | T8596 | arg2Of | proteins,discussed |
R5761 | T8596 | T8594 | arg2Of | discussed,are |
R5762 | T8596 | T8595 | arg1Of | discussed,not |
R5763 | T8596 | T8597 | arg1Of | discussed,here |
R5764 | T8596 | T8598 | arg1Of | discussed,"," |
R5765 | T8596 | T8599 | arg1Of | discussed,since |
R5766 | T8601 | T8600 | arg1Of | link,a |
R5767 | T8601 | T8602 | arg1Of | link,with |
R5768 | T8601 | T8605 | arg1Of | link,has |
R5769 | T8601 | T8608 | arg1Of | link,been |
R5770 | T8604 | T8602 | arg2Of | pathology,with |
R5771 | T8604 | T8603 | arg1Of | pathology,RA |
R5772 | T8608 | T8605 | arg2Of | been,has |
R5773 | T8608 | T8606 | arg1Of | been,not |
R5774 | T8608 | T8607 | arg1Of | been,yet |
R5775 | T8608 | T8609 | arg1Of | been,"reported. Although" |
R5776 | T8608 | T8620 | arg1Of | been,"," |
R5777 | T8610 | T8611 | arg1Of | IKK1,is |
R5778 | T8611 | T8609 | arg2Of | is,"reported. Although" |
R5779 | T8614 | T8611 | arg2Of | component,is |
R5780 | T8614 | T8612 | arg1Of | component,a |
R5781 | T8614 | T8613 | arg1Of | component,critical |
R5782 | T8614 | T8615 | arg1Of | component,of |
R5783 | T8619 | T8615 | arg2Of | pathway,of |
R5784 | T8619 | T8616 | arg1Of | pathway,the |
R5785 | T8619 | T8617 | arg1Of | pathway,non-canonical |
R5786 | T8619 | T8618 | arg1Of | pathway,NF-κB |
R5787 | T8620 | T8599 | arg2Of | ",",since |
R5788 | T8621 | T8622 | arg1Of | it,should |
R5789 | T8621 | T8623 | arg1Of | it,be |
R5790 | T8621 | T8624 | arg2Of | it,mentioned |
R5791 | T8624 | T8622 | arg2Of | mentioned,should |
R5792 | T8624 | T8623 | arg2Of | mentioned,be |
R5793 | T8624 | T8625 | arg1Of | mentioned,that |
R5794 | T8627 | T8626 | arg1Of | kinase,this |
R5795 | T8627 | T8629 | arg1Of | kinase,plays |
R5796 | T8629 | T8620 | arg2Of | plays,"," |
R5797 | T8629 | T8622 | modOf | plays,should |
R5798 | T8629 | T8628 | arg1Of | plays,also |
R5799 | T8629 | T8633 | arg1Of | plays,in |
R5800 | T8632 | T8629 | arg2Of | role,plays |
R5801 | T8632 | T8630 | arg1Of | role,a |
R5802 | T8632 | T8631 | arg1Of | role,prominent |
R5803 | T8636 | T8633 | arg2Of | regulation,in |
R5804 | T8636 | T8634 | arg1Of | regulation,the |
R5805 | T8636 | T8635 | arg1Of | regulation,negative |
R5806 | T8636 | T8637 | arg1Of | regulation,of |
R5807 | T8639 | T8640 | arg1Of | canonical,and |
R5808 | T8640 | T8638 | arg1Of | and,both |
R5809 | T8641 | T8640 | arg2Of | noncanonical,and |
R5810 | T8643 | T8637 | arg2Of | pathways,of |
R5811 | T8643 | T8639 | arg1Of | pathways,canonical |
R5812 | T8643 | T8641 | arg1Of | pathways,noncanonical |
R5813 | T8643 | T8642 | arg1Of | pathways,NF-κB |
R5814 | T8644 | T8645 | arg1Of | Macrophages,from |
R5815 | T8644 | T8654 | arg1Of | Macrophages,show |
R5816 | T8647 | T8646 | arg1Of | mice,IKK1-deficient |
R5817 | T8647 | T8648 | arg1Of | mice,or |
R5818 | T8648 | T8645 | arg2Of | or,from |
R5819 | T8650 | T8648 | arg2Of | mice,or |
R5820 | T8650 | T8649 | arg1Of | mice,knockin |
R5821 | T8650 | T8651 | arg1Of | mice,expressing |
R5822 | T8653 | T8651 | arg2Of | IKK1,expressing |
R5823 | T8653 | T8652 | arg1Of | IKK1,inactive |
R5824 | T8654 | T8660 | arg1Of | show,as |
R5825 | T8654 | T8670 | arg1Of | show,[ |
R5826 | T8656 | T8654 | arg2Of | production,show |
R5827 | T8656 | T8655 | arg2Of | production,increased |
R5828 | T8656 | T8657 | arg1Of | production,of |
R5829 | T8659 | T8657 | arg2Of | cytokines,of |
R5830 | T8659 | T8658 | arg1Of | cytokines,proinflammatory |
R5831 | T8662 | T8660 | arg2Of | result,as |
R5832 | T8662 | T8661 | arg1Of | result,a |
R5833 | T8662 | T8663 | arg1Of | result,of |
R5834 | T8666 | T8664 | arg2Of | activation,enhanced |
R5835 | T8666 | T8665 | arg1Of | activation,IKK2 |
R5836 | T8666 | T8667 | arg1Of | activation,and |
R5837 | T8667 | T8663 | arg2Of | and,of |
R5838 | T8669 | T8667 | arg2Of | degradation,and |
R5842 | T8673 | T8674 | arg1Of | IKK1,has |
R5843 | T8673 | T8676 | arg1Of | IKK1,been |
R5844 | T8673 | T8677 | arg2Of | IKK1,shown |
R5845 | T8673 | T8679 | arg1Of | IKK1,inhibit |
R5846 | T8673 | T8684 | arg1Of | IKK1,downregulate |
R5847 | T8673 | T8688 | arg1Of | IKK1,phosphorylating |
R5848 | T8677 | T8674 | arg2Of | shown,has |
R5849 | T8677 | T8675 | arg1Of | shown,also |
R5850 | T8677 | T8676 | arg2Of | shown,been |
R5851 | T8679 | T8678 | arg1Of | inhibit,to |
R5852 | T8679 | T8682 | arg1Of | inhibit,and |
R5853 | T8681 | T8679 | arg2Of | NF-κB,inhibit |
R5854 | T8681 | T8680 | arg1Of | NF-κB,nuclear |
R5855 | T8682 | T8677 | arg3Of | and,shown |
R5856 | T8684 | T8682 | arg2Of | downregulate,and |
R5857 | T8684 | T8683 | arg1Of | downregulate,to |
R5858 | T8684 | T8687 | arg1Of | downregulate,by |
R5859 | T8686 | T8684 | arg2Of | signalling,downregulate |
R5860 | T8686 | T8685 | arg1Of | signalling,proinflammatory |
R5861 | T8688 | T8687 | arg2Of | phosphorylating,by |
R5862 | T8689 | T8688 | arg2Of | STAT1,phosphorylating |
R5863 | T8689 | T8690 | arg1Of | STAT1,[ |
R5864 | T8691 | T8690 | arg2Of | 35,[ |
R5865 | T8692 | T8690 | arg3Of | ],[ |
R5866 | T8697 | T8695 | arg1Of | study,a |
R5867 | T8697 | T8696 | arg1Of | study,recent |
R5868 | T8697 | T8698 | arg1Of | study,has |
R5869 | T8697 | T8699 | arg1Of | study,demonstrated |
R5870 | T8699 | T8693 | arg1Of | demonstrated,Interestingly |
R5871 | T8699 | T8694 | arg1Of | demonstrated,"," |
R5872 | T8699 | T8698 | arg2Of | demonstrated,has |
R5873 | T8701 | T8702 | arg1Of | IKK1,phosphorylates |
R5874 | T8702 | T8699 | arg2Of | phosphorylates,demonstrated |
R5875 | T8702 | T8700 | arg1Of | phosphorylates,that |
R5876 | T8702 | T8704 | arg1Of | phosphorylates,in |
R5877 | T8702 | T8716 | arg1Of | phosphorylates,"," |
R5878 | T8702 | T8717 | modOf | phosphorylates,supporting |
R5879 | T8703 | T8702 | arg2Of | NIK,phosphorylates |
R5880 | T8707 | T8704 | arg2Of | regulation,in |
R5881 | T8707 | T8705 | arg1Of | regulation,negative |
R5882 | T8707 | T8706 | arg1Of | regulation,feedback |
R5883 | T8707 | T8708 | arg1Of | regulation,of |
R5884 | T8712 | T8708 | arg2Of | pathway,of |
R5885 | T8712 | T8709 | arg1Of | pathway,the |
R5886 | T8712 | T8710 | arg1Of | pathway,noncanonical |
R5887 | T8712 | T8711 | arg1Of | pathway,NF-κB |
R5888 | T8712 | T8713 | arg1Of | pathway,[ |
R5889 | T8714 | T8713 | arg2Of | 36,[ |
R5890 | T8715 | T8713 | arg3Of | ],[ |
R5891 | T8719 | T8717 | arg2Of | idea,supporting |
R5892 | T8719 | T8718 | arg1Of | idea,the |
R5893 | T8721 | T8722 | arg1Of | IKK1,plays |
R5894 | T8721 | T8726 | arg1Of | IKK1,terminating |
R5895 | T8722 | T8719 | arg2Of | plays,idea |
R5896 | T8722 | T8720 | arg1Of | plays,that |
R5897 | T8722 | T8725 | arg1Of | plays,in |
R5898 | T8724 | T8722 | arg2Of | roles,plays |
R5899 | T8724 | T8723 | arg1Of | roles,important |
R5900 | T8726 | T8725 | arg2Of | terminating,in |
R5901 | T8728 | T8729 | arg1Of | canonical,and |
R5902 | T8729 | T8727 | arg1Of | and,both |
R5903 | T8730 | T8729 | arg2Of | noncanonical,and |
R5904 | T8732 | T8726 | arg2Of | pathways,terminating |
R5905 | T8732 | T8728 | arg1Of | pathways,canonical |
R5906 | T8732 | T8730 | arg1Of | pathways,noncanonical |
R5907 | T8732 | T8731 | arg1Of | pathways,NF-κB |
R5908 | T8732 | T8733 | arg1Of | pathways,with |
R5909 | T8735 | T8733 | arg2Of | implications,with |
R5910 | T8735 | T8734 | arg1Of | implications,possible |
R5911 | T8735 | T8736 | arg1Of | implications,for |
R5912 | T8739 | T8736 | arg2Of | diseases,for |
R5913 | T8739 | T8737 | arg1Of | diseases,chronic |
R5914 | T8739 | T8738 | arg1Of | diseases,inflammatory |
R5915 | T8739 | T8740 | arg1Of | diseases,like |
R5916 | T8741 | T8740 | arg2Of | RA,like |
R6414 | T9822 | T9821 | arg1Of | protein,A20 |
R6415 | T9823 | T9824 | arg1Of | A20,( |
R6416 | T9823 | T9830 | arg1Of | A20,is |
R6417 | T9826 | T9824 | arg2Of | known,( |
R6418 | T9826 | T9825 | arg1Of | known,also |
R6419 | T9826 | T9827 | arg1Of | known,as |
R6420 | T9828 | T9827 | arg2Of | TNFAIP3,as |
R6421 | T9829 | T9824 | arg3Of | ),( |
R6422 | T9833 | T9830 | arg2Of | protein,is |
R6423 | T9833 | T9831 | arg1Of | protein,a |
R6424 | T9833 | T9832 | arg1Of | protein,ubiquitin-editing |
R6425 | T9833 | T9834 | arg1Of | protein,that |
R6426 | T9833 | T9836 | arg1Of | protein,regulates |
R6427 | T9836 | T9835 | arg1Of | regulates,negatively |
R6428 | T9836 | T9840 | arg1Of | regulates,in |
R6429 | T9839 | T9836 | arg2Of | expression,regulates |
R6430 | T9839 | T9837 | arg1Of | expression,NF-κB-dependent |
R6431 | T9839 | T9838 | arg1Of | expression,gene |
R6432 | T9841 | T9840 | arg2Of | response,in |
R6433 | T9841 | T9842 | arg1Of | response,to |
R6434 | T9845 | T9842 | arg2Of | stimuli,to |
R6435 | T9845 | T9843 | arg1Of | stimuli,different |
R6436 | T9845 | T9844 | arg1Of | stimuli,immune-activating |
R6437 | T9845 | T9846 | arg1Of | stimuli,"," |
R6438 | T9845 | T9847 | arg1Of | stimuli,including |
R6439 | T9848 | T9849 | arg1Of | TNF,"," |
R6440 | T9849 | T9851 | arg1Of | ",",and |
R6441 | T9850 | T9849 | arg2Of | IL-1,"," |
R6442 | T9851 | T9854 | arg1Of | and,and |
R6443 | T9852 | T9851 | arg2Of | antigens,and |
R6444 | T9854 | T9847 | arg2Of | and,including |
R6445 | T9854 | T9853 | arg1Of | and,"," |
R6446 | T9856 | T9854 | arg2Of | triggering,and |
R6447 | T9856 | T9855 | arg1Of | triggering,the |
R6448 | T9856 | T9857 | arg1Of | triggering,of |
R6449 | T9858 | T9859 | arg1Of | TLRs,and |
R6450 | T9859 | T9857 | arg2Of | and,of |
R6451 | T9862 | T9860 | arg1Of | oligomerisation,the |
R6452 | T9862 | T9861 | arg1Of | oligomerisation,nucleotide-binding |
R6453 | T9865 | T9859 | arg2Of | receptor,and |
R6454 | T9865 | T9862 | arg1Of | receptor,oligomerisation |
R6455 | T9865 | T9863 | arg1Of | receptor,domain-containing |
R6456 | T9865 | T9864 | arg1Of | receptor,2 |
R6457 | T9865 | T9866 | arg1Of | receptor,( |
R6458 | T9867 | T9866 | arg2Of | reviewed,( |
R6459 | T9867 | T9868 | arg1Of | reviewed,in |
R6460 | T9867 | T9869 | arg1Of | reviewed,[ |
R6461 | T9870 | T9869 | arg2Of | 37,[ |
R6462 | T9871 | T9869 | arg3Of | ],[ |
R6463 | T9872 | T9866 | arg3Of | ),( |
R6464 | T9873 | T9874 | arg1Of | A20,is |
R6465 | T9873 | T9875 | arg2Of | A20,believed |
R6466 | T9873 | T9877 | arg1Of | A20,inhibit |
R6467 | T9873 | T9881 | arg1Of | A20,deubiquitinating |
R6468 | T9875 | T9874 | arg2Of | believed,is |
R6469 | T9877 | T9875 | arg3Of | inhibit,believed |
R6470 | T9877 | T9876 | arg1Of | inhibit,to |
R6471 | T9877 | T9880 | arg1Of | inhibit,by |
R6472 | T9879 | T9877 | arg2Of | function,inhibit |
R6473 | T9879 | T9878 | arg1Of | function,NF-κB |
R6474 | T9881 | T9880 | arg2Of | deubiquitinating,by |
R6475 | T9885 | T9881 | arg2Of | molecules,deubiquitinating |
R6476 | T9885 | T9882 | arg1Of | molecules,specific |
R6477 | T9885 | T9883 | arg1Of | molecules,NF-κB |
R6478 | T9885 | T9884 | arg1Of | molecules,signalling |
R6479 | T9885 | T9886 | arg1Of | molecules,"," |
R6480 | T9885 | T9888 | arg1Of | molecules,as |
R6481 | T9888 | T9887 | arg1Of | as,such |
R6482 | T9889 | T9890 | arg1Of | RIP1,"," |
R6483 | T9890 | T9892 | arg1Of | ",","," |
R6484 | T9891 | T9890 | arg2Of | RIP2,"," |
R6485 | T9892 | T9894 | arg1Of | ",",and |
R6486 | T9893 | T9892 | arg2Of | TRAF6,"," |
R6487 | T9894 | T9888 | arg2Of | and,as |
R6488 | T9894 | T9896 | arg1Of | and,"," |
R6489 | T9894 | T9897 | arg1Of | and,which |
R6490 | T9894 | T9898 | arg1Of | and,disrupts |
R6491 | T9895 | T9894 | arg2Of | MALT1,and |
R6492 | T9898 | T9902 | arg1Of | disrupts,[ |
R6493 | T9898 | T9905 | arg1Of | disrupts,( |
R6494 | T9901 | T9898 | arg2Of | interactions,disrupts |
R6495 | T9901 | T9899 | arg1Of | interactions,specific |
R6496 | T9901 | T9900 | arg1Of | interactions,protein-protein |
R6497 | T9903 | T9902 | arg2Of | 38-41,[ |
R6498 | T9904 | T9902 | arg3Of | ],[ |
R6499 | T9906 | T9905 | arg2Of | Figure,( |
R6500 | T9906 | T9907 | arg1Of | Figure,1 |
R6501 | T9908 | T9905 | arg3Of | ),( |
R6502 | T9912 | T9911 | arg1Of | disruption,the |
R6503 | T9912 | T9913 | arg1Of | disruption,of |
R6504 | T9912 | T9915 | arg1Of | disruption,between |
R6505 | T9912 | T9925 | arg1Of | disruption,and |
R6506 | T9914 | T9913 | arg2Of | interactions,of |
R6507 | T9919 | T9915 | arg2Of | enzymes,between |
R6508 | T9919 | T9916 | arg1Of | enzymes,E2 |
R6509 | T9919 | T9917 | arg1Of | enzymes,ubiquitin |
R6510 | T9919 | T9918 | arg1Of | enzymes,conjugating |
R6511 | T9919 | T9920 | arg1Of | enzymes,( |
R6512 | T9921 | T9922 | arg1Of | Ubc13,and |
R6513 | T9922 | T9920 | arg2Of | and,( |
R6514 | T9923 | T9922 | arg2Of | Ubc5hc,and |
R6515 | T9924 | T9920 | arg3Of | ),( |
R6516 | T9925 | T9936 | arg1Of | and,were |
R6517 | T9925 | T9937 | arg2Of | and,described |
R6518 | T9928 | T9925 | arg2Of | ligases,and |
R6519 | T9928 | T9926 | arg1Of | ligases,E3 |
R6520 | T9928 | T9927 | arg1Of | ligases,ubiquitin |
R6521 | T9928 | T9929 | arg1Of | ligases,( |
R6522 | T9930 | T9931 | arg1Of | TRAF6,"," |
R6523 | T9931 | T9933 | arg1Of | ",",and |
R6524 | T9932 | T9931 | arg2Of | TRAF2,"," |
R6525 | T9933 | T9929 | arg2Of | and,( |
R6526 | T9934 | T9933 | arg2Of | cIAP1/2,and |
R6527 | T9935 | T9929 | arg3Of | ),( |
R6528 | T9937 | T9909 | arg1Of | described,Recently |
R6529 | T9937 | T9910 | arg1Of | described,"," |
R6530 | T9937 | T9936 | arg2Of | described,were |
R6531 | T9937 | T9938 | arg1Of | described,as |
R6532 | T9941 | T9938 | arg2Of | mechanism,as |
R6533 | T9941 | T9939 | arg1Of | mechanism,another |
R6534 | T9941 | T9940 | arg1Of | mechanism,important |
R6535 | T9941 | T9942 | arg2Of | mechanism,used |
R6536 | T9942 | T9943 | arg1Of | used,by |
R6537 | T9942 | T9945 | modOf | used,to |
R6538 | T9944 | T9943 | arg2Of | A20,by |
R6539 | T9946 | T9945 | arg1Of | downregulate,to |
R6540 | T9946 | T9949 | arg1Of | downregulate,[ |
R6541 | T9948 | T9946 | arg2Of | signalling,downregulate |
R6542 | T9948 | T9947 | arg1Of | signalling,NF-κB |
R6543 | T9950 | T9949 | arg2Of | 42,[ |
R6544 | T9951 | T9949 | arg3Of | ],[ |
R6545 | T9953 | T9952 | arg1Of | association,The |
R6546 | T9953 | T9954 | arg1Of | association,of |
R6547 | T9953 | T9956 | arg1Of | association,with |
R6548 | T9953 | T9959 | arg1Of | association,requires |
R6549 | T9955 | T9954 | arg2Of | A20,of |
R6550 | T9958 | T9956 | arg2Of | targets,with |
R6551 | T9958 | T9957 | arg1Of | targets,its |
R6552 | T9963 | T9959 | arg2Of | proteins,requires |
R6553 | T9963 | T9960 | arg1Of | proteins,specific |
R6554 | T9963 | T9961 | arg1Of | proteins,ubiquitin-binding |
R6555 | T9963 | T9962 | arg1Of | proteins,adaptor |
R6556 | T9963 | T9964 | arg1Of | proteins,"," |
R6557 | T9963 | T9965 | arg1Of | proteins,including |
R6558 | T9967 | T9965 | arg2Of | inhibitor,including |
R6559 | T9967 | T9966 | arg1Of | inhibitor,A20-binding |
R6560 | T9967 | T9968 | arg1Of | inhibitor,of |
R6561 | T9969 | T9970 | arg1Of | NF-κB,( |
R6562 | T9969 | T9973 | arg1Of | NF-κB,1 |
R6563 | T9969 | T9974 | arg1Of | NF-κB,and |
R6564 | T9971 | T9970 | arg2Of | ABIN,( |
R6565 | T9972 | T9970 | arg3Of | ),( |
R6566 | T9974 | T9968 | arg2Of | and,of |
R6567 | T9976 | T9974 | arg2Of | protein,and |
R6568 | T9976 | T9975 | arg1Of | protein,Tax1-binding |
R6569 | T9976 | T9977 | arg1Of | protein,1 |
R6570 | T9976 | T9978 | arg1Of | protein,[ |
R6571 | T9979 | T9978 | arg2Of | 43-46,[ |
R6572 | T9980 | T9978 | arg3Of | ],[ |
R6573 | T9981 | T9982 | arg1Of | Next,to |
R6574 | T9984 | T9982 | arg2Of | role,to |
R6575 | T9984 | T9983 | arg1Of | role,its |
R6576 | T9984 | T9985 | arg1Of | role,in |
R6577 | T9986 | T9985 | arg2Of | suppressing,in |
R6578 | T9988 | T9986 | arg2Of | activation,suppressing |
R6579 | T9988 | T9987 | arg1Of | activation,NF-κB |
R6580 | T9990 | T9991 | arg1Of | A20,is |
R6581 | T9991 | T9981 | arg1Of | is,Next |
R6582 | T9991 | T9989 | arg1Of | is,"," |
R6583 | T9991 | T9992 | arg1Of | is,also |
R6584 | T9991 | T9998 | arg1Of | is,"," |
R6585 | T9991 | T10001 | arg1Of | is,in |
R6586 | T9995 | T9991 | arg2Of | inhibitor,is |
R6587 | T9995 | T9993 | arg1Of | inhibitor,a |
R6588 | T9995 | T9994 | arg1Of | inhibitor,strong |
R6589 | T9995 | T9996 | arg1Of | inhibitor,of |
R6590 | T9997 | T9996 | arg2Of | apoptosis,of |
R6591 | T10000 | T9999 | arg1Of | least,at |
R6592 | T10001 | T10000 | arg1Of | in,least |
R6593 | T10004 | T10001 | arg2Of | types,in |
R6594 | T10004 | T10002 | arg1Of | types,some |
R6595 | T10004 | T10003 | arg1Of | types,cell |
R6596 | T10006 | T10005 | arg1Of | mechanisms,The |
R6597 | T10006 | T10007 | arg2Of | mechanisms,by |
R6598 | T10006 | T10008 | arg1Of | mechanisms,which |
R6599 | T10006 | T10016 | arg1Of | mechanisms,are |
R6600 | T10006 | T10018 | arg1Of | mechanisms,elusive |
R6601 | T10009 | T10010 | arg1Of | A20,regulates |
R6602 | T10010 | T10007 | arg1Of | regulates,by |
R6603 | T10012 | T10010 | arg2Of | signalling,regulates |
R6604 | T10012 | T10011 | arg1Of | signalling,apoptotic |
R6605 | T10016 | T10013 | arg1Of | are,"," |
R6606 | T10016 | T10014 | arg1Of | are,however |
R6607 | T10016 | T10015 | arg1Of | are,"," |
R6608 | T10016 | T10017 | arg1Of | are,still |
R6609 | T10018 | T10016 | arg2Of | elusive,are |
R6610 | T10020 | T10019 | arg1Of | mice,A20-deficient |
R6611 | T10020 | T10022 | arg1Of | mice,develop |
R6612 | T10020 | T10028 | arg1Of | mice,die |
R6613 | T10020 | T10035 | arg1Of | mice,illustrating |
R6614 | T10022 | T10027 | arg1Of | develop,and |
R6615 | T10024 | T10025 | arg1Of | inflammation,and |
R6616 | T10025 | T10022 | arg2Of | and,develop |
R6617 | T10025 | T10023 | arg1Of | and,multiorgan |
R6618 | T10026 | T10025 | arg2Of | cachexia,and |
R6619 | T10027 | T10034 | arg1Of | and,"," |
R6620 | T10028 | T10027 | arg2Of | die,and |
R6621 | T10028 | T10029 | arg1Of | die,within |
R6622 | T10031 | T10029 | arg2Of | weeks,within |
R6623 | T10031 | T10030 | arg1Of | weeks,2 |
R6624 | T10031 | T10032 | arg1Of | weeks,of |
R6625 | T10033 | T10032 | arg2Of | birth,of |
R6626 | T10034 | T10021 | arg1Of | ",",spontaneously |
R6627 | T10034 | T10043 | arg1Of | ",",[ |
R6628 | T10035 | T10034 | arg2Of | illustrating,"," |
R6629 | T10039 | T10035 | arg2Of | function,illustrating |
R6630 | T10039 | T10036 | arg1Of | function,the |
R6631 | T10039 | T10037 | arg1Of | function,potent |
R6632 | T10039 | T10038 | arg1Of | function,anti-inflammatory |
R6633 | T10039 | T10040 | arg1Of | function,of |
R6634 | T10042 | T10040 | arg2Of | molecule,of |
R6635 | T10042 | T10041 | arg1Of | molecule,this |
R6636 | T10044 | T10043 | arg2Of | 46,[ |
R6637 | T10045 | T10043 | arg3Of | ],[ |
R6638 | T10047 | T10046 | arg1Of | cells,A20-deficient |
R6639 | T10047 | T10048 | arg1Of | cells,are |
R6640 | T10047 | T10051 | arg1Of | cells,susceptible |
R6641 | T10048 | T10049 | arg1Of | are,also |
R6642 | T10048 | T10055 | arg1Of | are,"," |
R6643 | T10048 | T10056 | modOf | are,confirming |
R6644 | T10051 | T10048 | arg2Of | susceptible,are |
R6645 | T10051 | T10050 | arg1Of | susceptible,more |
R6646 | T10051 | T10052 | arg1Of | susceptible,to |
R6647 | T10054 | T10052 | arg2Of | apoptosis,to |
R6648 | T10054 | T10053 | arg1Of | apoptosis,TNF-mediated |
R6649 | T10058 | T10056 | arg2Of | role,confirming |
R6650 | T10058 | T10057 | arg1Of | role,its |
R6651 | T10058 | T10059 | arg1Of | role,as |
R6652 | T10062 | T10059 | arg2Of | protein,as |
R6653 | T10062 | T10060 | arg1Of | protein,an |
R6654 | T10062 | T10061 | arg1Of | protein,antiapoptotic |
R6655 | T10063 | T10065 | arg1Of | We,showed |
R6656 | T10065 | T10064 | arg1Of | showed,recently |
R6657 | T10067 | T10069 | arg1Of | mice,lacking |
R6658 | T10067 | T10075 | arg1Of | mice,exhibit |
R6659 | T10069 | T10068 | arg1Of | lacking,specifically |
R6660 | T10069 | T10071 | arg1Of | lacking,in |
R6661 | T10070 | T10069 | arg2Of | A20,lacking |
R6662 | T10074 | T10071 | arg2Of | cells,in |
R6663 | T10074 | T10072 | arg1Of | cells,intestinal |
R6664 | T10074 | T10073 | arg1Of | cells,epithelial |
R6665 | T10075 | T10065 | arg2Of | exhibit,showed |
R6666 | T10075 | T10066 | arg1Of | exhibit,that |
R6667 | T10075 | T10093 | arg1Of | exhibit,"," |
R6668 | T10075 | T10094 | modOf | exhibit,confirming |
R6669 | T10077 | T10075 | arg2Of | susceptibility,exhibit |
R6670 | T10077 | T10076 | arg2Of | susceptibility,increased |
R6671 | T10077 | T10078 | arg1Of | susceptibility,to |
R6672 | T10077 | T10082 | arg1Of | susceptibility,to |
R6673 | T10080 | T10078 | arg2Of | colitis,to |
R6674 | T10080 | T10079 | arg1Of | colitis,experimental |
R6675 | T10082 | T10081 | arg1Of | to,due |
R6676 | T10084 | T10082 | arg2Of | hypersensitivity,to |
R6677 | T10084 | T10083 | arg1Of | hypersensitivity,the |
R6678 | T10084 | T10085 | arg1Of | hypersensitivity,of |
R6679 | T10084 | T10090 | arg1Of | hypersensitivity,to |
R6680 | T10089 | T10085 | arg2Of | cells,of |
R6681 | T10089 | T10086 | arg1Of | cells,their |
R6682 | T10089 | T10087 | arg1Of | cells,intestinal |
R6683 | T10089 | T10088 | arg1Of | cells,epithelial |
R6684 | T10092 | T10090 | arg2Of | apoptosis,to |
R6685 | T10092 | T10091 | arg1Of | apoptosis,TNF-induced |
R6686 | T10094 | T10096 | arg1Of | confirming,as |
R6687 | T10094 | T10105 | arg1Of | confirming,[ |
R6688 | T10095 | T10094 | arg2Of | A20,confirming |
R6689 | T10100 | T10096 | arg2Of | protein,as |
R6690 | T10100 | T10097 | arg1Of | protein,a |
R6691 | T10100 | T10098 | arg1Of | protein,major |
R6692 | T10100 | T10099 | arg1Of | protein,antiapoptotic |
R6693 | T10100 | T10101 | arg1Of | protein,in |
R6694 | T10104 | T10101 | arg2Of | epithelium,in |
R6695 | T10104 | T10102 | arg1Of | epithelium,the |
R6696 | T10104 | T10103 | arg1Of | epithelium,intestinal |
R6697 | T10106 | T10105 | arg2Of | 47,[ |
R6698 | T10107 | T10105 | arg3Of | ],[ |
R6699 | T10110 | T10108 | arg1Of | studies,Two |
R6700 | T10110 | T10109 | arg1Of | studies,independent |
R6701 | T10110 | T10111 | arg1Of | studies,showed |
R6702 | T10113 | T10114 | arg1Of | mice,lacking |
R6703 | T10113 | T10119 | arg1Of | mice,develop |
R6704 | T10114 | T10116 | arg1Of | lacking,in |
R6705 | T10115 | T10114 | arg2Of | A20,lacking |
R6706 | T10118 | T10116 | arg2Of | cells,in |
R6707 | T10118 | T10117 | arg1Of | cells,B |
R6708 | T10119 | T10111 | arg2Of | develop,showed |
R6709 | T10119 | T10112 | arg1Of | develop,that |
R6710 | T10119 | T10122 | arg1Of | develop,to |
R6711 | T10120 | T10119 | arg2Of | autoimmunity,develop |
R6712 | T10122 | T10121 | arg1Of | to,due |
R6713 | T10125 | T10122 | arg2Of | responses,to |
R6714 | T10125 | T10123 | arg1Of | responses,hyperactive |
R6715 | T10125 | T10124 | arg1Of | responses,NF-κB |
R6716 | T10125 | T10126 | arg1Of | responses,in |
R6717 | T10128 | T10126 | arg2Of | cells,in |
R6718 | T10128 | T10127 | arg1Of | cells,B |
R6719 | T10128 | T10129 | arg1Of | cells,leading |
R6720 | T10129 | T10130 | arg1Of | leading,to |
R6721 | T10133 | T10130 | arg2Of | survival,to |
R6722 | T10133 | T10131 | arg1Of | survival,unrestricted |
R6723 | T10133 | T10132 | arg1Of | survival,B-cell |
R6724 | T10133 | T10134 | arg1Of | survival,[ |
R6725 | T10135 | T10134 | arg2Of | "48,49",[ |
R6726 | T10136 | T10134 | arg3Of | ],[ |
R6727 | T10138 | T10137 | arg1Of | expression,A20 |
R6728 | T10138 | T10139 | arg1Of | expression,has |
R6729 | T10138 | T10140 | arg1Of | expression,been |
R6730 | T10138 | T10141 | arg2Of | expression,observed |
R6731 | T10141 | T10139 | arg2Of | observed,has |
R6732 | T10141 | T10140 | arg2Of | observed,been |
R6733 | T10141 | T10142 | arg1Of | observed,in |
R6734 | T10145 | T10142 | arg2Of | types,in |
R6735 | T10145 | T10143 | arg1Of | types,several |
R6736 | T10145 | T10144 | arg1Of | types,cell |
R6737 | T10145 | T10146 | arg1Of | types,that |
R6738 | T10145 | T10147 | arg1Of | types,play |
R6739 | T10145 | T10155 | arg1Of | types,"," |
R6740 | T10145 | T10157 | arg1Of | types,as |
R6741 | T10147 | T10150 | arg1Of | play,in |
R6742 | T10149 | T10147 | arg2Of | roles,play |
R6743 | T10149 | T10148 | arg1Of | roles,important |
R6744 | T10152 | T10150 | arg2Of | pathophysiology,in |
R6745 | T10152 | T10151 | arg1Of | pathophysiology,the |
R6746 | T10152 | T10153 | arg1Of | pathophysiology,of |
R6747 | T10154 | T10153 | arg2Of | RA,of |
R6748 | T10157 | T10156 | arg1Of | as,such |
R6749 | T10158 | T10159 | arg1Of | fibroblasts,"," |
R6750 | T10159 | T10161 | arg1Of | ",",and |
R6751 | T10160 | T10159 | arg2Of | synoviocytes,"," |
R6752 | T10161 | T10157 | arg2Of | and,as |
R6753 | T10162 | T10161 | arg2Of | lymphocytes,and |
R6754 | T10166 | T10165 | arg1Of | expression,A20 |
R6755 | T10166 | T10167 | arg1Of | expression,is |
R6756 | T10166 | T10169 | arg2Of | expression,regulated |
R6757 | T10166 | T10176 | arg1Of | expression,implicating |
R6758 | T10169 | T10163 | arg1Of | regulated,Interestingly |
R6759 | T10169 | T10164 | arg1Of | regulated,"," |
R6760 | T10169 | T10167 | arg2Of | regulated,is |
R6761 | T10169 | T10168 | arg1Of | regulated,itself |
R6762 | T10169 | T10175 | arg1Of | regulated,"," |
R6763 | T10169 | T10176 | modOf | regulated,implicating |
R6764 | T10171 | T10169 | arg1Of | NF-κB,regulated |
R6765 | T10171 | T10170 | arg2Of | NF-κB,by |
R6766 | T10171 | T10172 | arg1Of | NF-κB,[ |
R6767 | T10173 | T10172 | arg2Of | 50,[ |
R6768 | T10174 | T10172 | arg3Of | ],[ |
R6769 | T10176 | T10178 | arg1Of | implicating,in |
R6770 | T10177 | T10176 | arg2Of | A20,implicating |
R6771 | T10182 | T10178 | arg2Of | regulation,in |
R6772 | T10182 | T10179 | arg1Of | regulation,the |
R6773 | T10182 | T10180 | arg1Of | regulation,negative |
R6774 | T10182 | T10181 | arg1Of | regulation,feedback |
R6775 | T10182 | T10183 | arg1Of | regulation,of |
R6776 | T10185 | T10183 | arg2Of | signalling,of |
R6777 | T10185 | T10184 | arg1Of | signalling,NF-κB |
R6778 | T10189 | T10188 | arg1Of | injection,intra-articular |
R6779 | T10189 | T10190 | arg1Of | injection,of |
R6780 | T10189 | T10194 | arg1Of | injection,was |
R6781 | T10189 | T10195 | arg2Of | injection,shown |
R6782 | T10189 | T10197 | arg1Of | injection,reduce |
R6783 | T10193 | T10190 | arg2Of | adenovirus,of |
R6784 | T10193 | T10191 | arg1Of | adenovirus,an |
R6785 | T10193 | T10192 | arg1Of | adenovirus,A20-expressing |
R6786 | T10195 | T10186 | arg1Of | shown,Recently |
R6787 | T10195 | T10187 | arg1Of | shown,"," |
R6788 | T10195 | T10194 | arg2Of | shown,was |
R6789 | T10197 | T10195 | arg3Of | reduce,shown |
R6790 | T10197 | T10196 | arg1Of | reduce,to |
R6791 | T10197 | T10206 | arg1Of | reduce,in |
R6792 | T10197 | T10213 | arg1Of | reduce,"," |
R6793 | T10197 | T10215 | arg1Of | reduce,in |
R6794 | T10197 | T10218 | arg1Of | reduce,"," |
R6795 | T10197 | T10219 | arg1Of | reduce,in |
R6796 | T10199 | T10197 | arg2Of | severity,reduce |
R6797 | T10199 | T10198 | arg1Of | severity,the |
R6798 | T10199 | T10200 | arg1Of | severity,of |
R6799 | T10202 | T10201 | arg1Of | inflammation,synovial |
R6800 | T10202 | T10203 | arg1Of | inflammation,and |
R6801 | T10203 | T10200 | arg2Of | and,of |
R6802 | T10205 | T10203 | arg2Of | destruction,and |
R6803 | T10205 | T10204 | arg1Of | destruction,joint |
R6804 | T10209 | T10206 | arg2Of | model,in |
R6805 | T10209 | T10207 | arg1Of | model,a |
R6806 | T10209 | T10208 | arg1Of | model,mouse |
R6807 | T10209 | T10210 | arg1Of | model,of |
R6808 | T10212 | T10210 | arg2Of | arthritis,of |
R6809 | T10212 | T10211 | arg1Of | arthritis,collagen-induced |
R6810 | T10215 | T10214 | arg1Of | in,even |
R6811 | T10217 | T10215 | arg2Of | joints,in |
R6812 | T10217 | T10216 | arg1Of | joints,untreated |
R6813 | T10222 | T10223 | arg1Of | prophylactic,and |
R6814 | T10224 | T10223 | arg2Of | therapeutic,and |
R6815 | T10225 | T10219 | arg2Of | setting,in |
R6816 | T10225 | T10220 | arg1Of | setting,both |
R6817 | T10225 | T10221 | arg1Of | setting,a |
R6818 | T10225 | T10222 | arg1Of | setting,prophylactic |
R6819 | T10225 | T10224 | arg1Of | setting,therapeutic |
R6820 | T10227 | T10226 | arg1Of | expression,A20 |
R6821 | T10227 | T10228 | arg1Of | expression,in |
R6822 | T10227 | T10231 | arg1Of | expression,was |
R6823 | T10227 | T10232 | arg2Of | expression,associated |
R6824 | T10230 | T10228 | arg2Of | tissue,in |
R6825 | T10230 | T10229 | arg1Of | tissue,synovial |
R6826 | T10232 | T10231 | arg2Of | associated,was |
R6827 | T10232 | T10233 | arg1Of | associated,with |
R6828 | T10232 | T10258 | arg1Of | associated,"," |
R6829 | T10232 | T10259 | modOf | associated,suggesting |
R6830 | T10234 | T10233 | arg2Of | inhibition,with |
R6831 | T10234 | T10235 | arg1Of | inhibition,of |
R6832 | T10234 | T10241 | arg1Of | inhibition,of |
R6833 | T10237 | T10236 | arg1Of | activity,NF-κB |
R6834 | T10237 | T10238 | arg1Of | activity,and |
R6835 | T10238 | T10235 | arg2Of | and,of |
R6836 | T10240 | T10238 | arg2Of | levels,and |
R6837 | T10240 | T10239 | arg2Of | levels,decreased |
R6838 | T10242 | T10243 | arg1Of | TNF,"," |
R6839 | T10243 | T10245 | arg1Of | ",","," |
R6840 | T10244 | T10243 | arg2Of | IL-1β,"," |
R6841 | T10245 | T10247 | arg1Of | ",","," |
R6842 | T10246 | T10245 | arg2Of | IL-6,"," |
R6843 | T10247 | T10250 | arg1Of | ",","," |
R6844 | T10249 | T10247 | arg2Of | RANKL,"," |
R6845 | T10249 | T10248 | arg1Of | RANKL,soluble |
R6846 | T10250 | T10256 | arg1Of | ",",and |
R6847 | T10253 | T10250 | arg2Of | protein,"," |
R6848 | T10253 | T10251 | arg1Of | protein,monocyte |
R6849 | T10253 | T10252 | arg1Of | protein,chemo-attractant |
R6850 | T10253 | T10254 | arg1Of | protein,1 |
R6851 | T10256 | T10241 | arg2Of | and,of |
R6852 | T10256 | T10255 | arg1Of | and,"," |
R6853 | T10257 | T10256 | arg2Of | IL-17,and |
R6854 | T10261 | T10262 | arg1Of | A20,induces |
R6855 | T10262 | T10259 | arg2Of | induces,suggesting |
R6856 | T10262 | T10260 | arg1Of | induces,that |
R6857 | T10262 | T10266 | arg1Of | induces,in |
R6858 | T10262 | T10270 | arg1Of | induces,through |
R6859 | T10262 | T10280 | arg1Of | induces,[ |
R6860 | T10265 | T10262 | arg2Of | effect,induces |
R6861 | T10265 | T10263 | arg1Of | effect,a |
R6862 | T10265 | T10264 | arg1Of | effect,protective |
R6863 | T10269 | T10266 | arg2Of | mice,in |
R6864 | T10269 | T10267 | arg1Of | mice,collagen-induced |
R6865 | T10269 | T10268 | arg1Of | mice,arthritis |
R6866 | T10271 | T10272 | arg1Of | suppression,of |
R6867 | T10271 | T10275 | arg1Of | suppression,and |
R6868 | T10274 | T10272 | arg2Of | activation,of |
R6869 | T10274 | T10273 | arg1Of | activation,NF-κB |
R6870 | T10275 | T10270 | arg2Of | and,through |
R6871 | T10279 | T10275 | arg2Of | expression,and |
R6872 | T10279 | T10276 | arg1Of | expression,NF- |
R6873 | T10279 | T10277 | arg1Of | expression,κB-dependent |
R6874 | T10279 | T10278 | arg1Of | expression,gene |
R6875 | T10281 | T10280 | arg2Of | 51,[ |
R6876 | T10282 | T10280 | arg3Of | ],[ |
R6877 | T10284 | T10285 | arg1Of | TNF,and |
R6878 | T10285 | T10287 | arg1Of | and,are |
R6879 | T10285 | T10288 | arg2Of | and,known |
R6880 | T10285 | T10290 | arg1Of | and,mediate |
R6881 | T10286 | T10285 | arg2Of | IL-1β,and |
R6882 | T10288 | T10283 | arg2Of | known,Because |
R6883 | T10288 | T10287 | arg2Of | known,are |
R6884 | T10290 | T10288 | arg3Of | mediate,known |
R6885 | T10290 | T10289 | arg1Of | mediate,to |
R6886 | T10291 | T10292 | arg1Of | synovitis,"," |
R6887 | T10292 | T10296 | arg1Of | ",",and |
R6888 | T10294 | T10292 | arg2Of | formation,"," |
R6889 | T10294 | T10293 | arg1Of | formation,pannus |
R6890 | T10296 | T10290 | arg2Of | and,mediate |
R6891 | T10296 | T10295 | arg1Of | and,"," |
R6892 | T10296 | T10298 | arg1Of | and,of |
R6893 | T10297 | T10296 | arg2Of | erosion,and |
R6894 | T10299 | T10300 | arg1Of | cartilage,and |
R6895 | T10300 | T10298 | arg2Of | and,of |
R6896 | T10300 | T10302 | arg1Of | and,in |
R6897 | T10301 | T10300 | arg2Of | bone,and |
R6898 | T10303 | T10302 | arg2Of | RA,in |
R6899 | T10308 | T10305 | arg1Of | levels,the |
R6900 | T10308 | T10306 | arg2Of | levels,decreased |
R6901 | T10308 | T10307 | arg1Of | levels,serum |
R6902 | T10308 | T10309 | arg1Of | levels,of |
R6903 | T10308 | T10316 | arg1Of | levels,might |
R6904 | T10308 | T10317 | arg1Of | levels,explain |
R6905 | T10310 | T10311 | arg1Of | TNF,and |
R6906 | T10311 | T10309 | arg2Of | and,of |
R6907 | T10311 | T10313 | arg1Of | and,in |
R6908 | T10312 | T10311 | arg2Of | IL-1β,and |
R6909 | T10315 | T10313 | arg2Of | mice,in |
R6910 | T10315 | T10314 | arg1Of | mice,A20-transduced |
R6911 | T10317 | T10283 | arg1Of | explain,Because |
R6912 | T10317 | T10304 | arg1Of | explain,"," |
R6913 | T10317 | T10316 | arg2Of | explain,might |
R6914 | T10317 | T10321 | arg1Of | explain,in |
R6915 | T10320 | T10317 | arg2Of | effects,explain |
R6916 | T10320 | T10318 | arg1Of | effects,the |
R6917 | T10320 | T10319 | arg1Of | effects,beneficial |
R6918 | T10323 | T10324 | arg1Of | clinical,"," |
R6919 | T10324 | T10327 | arg1Of | ",",and |
R6920 | T10325 | T10324 | arg2Of | pathological,"," |
R6921 | T10327 | T10326 | arg1Of | and,"," |
R6922 | T10328 | T10327 | arg2Of | radiological,and |
R6923 | T10329 | T10321 | arg2Of | findings,in |
R6924 | T10329 | T10322 | arg1Of | findings,the |
R6925 | T10329 | T10323 | arg1Of | findings,clinical |
R6926 | T10329 | T10325 | arg1Of | findings,pathological |
R6927 | T10329 | T10328 | arg1Of | findings,radiological |
R6928 | T10331 | T10330 | arg1Of | study,This |
R6929 | T10331 | T10333 | arg1Of | study,demonstrated |
R6930 | T10333 | T10332 | arg1Of | demonstrated,also |
R6931 | T10336 | T10335 | arg1Of | overexpression,A20 |
R6932 | T10336 | T10337 | arg1Of | overexpression,leads |
R6933 | T10337 | T10333 | arg2Of | leads,demonstrated |
R6934 | T10337 | T10334 | arg1Of | leads,that |
R6935 | T10337 | T10338 | arg1Of | leads,to |
R6936 | T10340 | T10338 | arg2Of | decrease,to |
R6937 | T10340 | T10339 | arg1Of | decrease,a |
R6938 | T10340 | T10341 | arg1Of | decrease,in |
R6939 | T10343 | T10341 | arg2Of | number,in |
R6940 | T10343 | T10342 | arg1Of | number,the |
R6941 | T10343 | T10344 | arg1Of | number,of |
R6942 | T10343 | T10347 | arg1Of | number,in |
R6943 | T10346 | T10344 | arg2Of | osteoclasts,of |
R6944 | T10346 | T10345 | arg2Of | osteoclasts,activated |
R6945 | T10349 | T10347 | arg2Of | tissue,in |
R6946 | T10349 | T10348 | arg1Of | tissue,joint |
R6947 | T10350 | T10351 | arg1Of | A20,might |
R6948 | T10350 | T10353 | arg1Of | A20,minimise |
R6949 | T10350 | T10357 | arg1Of | A20,decreasing |
R6950 | T10353 | T10351 | arg2Of | minimise,might |
R6951 | T10353 | T10352 | arg1Of | minimise,therefore |
R6952 | T10353 | T10356 | arg1Of | minimise,through |
R6953 | T10355 | T10353 | arg2Of | destruction,minimise |
R6954 | T10355 | T10354 | arg1Of | destruction,joint |
R6955 | T10357 | T10356 | arg2Of | decreasing,through |
R6956 | T10360 | T10361 | arg1Of | number,and |
R6957 | T10361 | T10357 | arg2Of | and,decreasing |
R6958 | T10361 | T10358 | arg1Of | and,the |
R6959 | T10361 | T10359 | arg1Of | and,osteoclast |
R6960 | T10362 | T10361 | arg2Of | activity,and |
R6961 | T10365 | T10364 | arg2Of | be,will |
R6962 | T10366 | T10365 | arg2Of | interesting,be |
R6963 | T10368 | T10363 | arg1Of | analyse,It |
R6964 | T10368 | T10364 | arg1Of | analyse,will |
R6965 | T10368 | T10365 | arg1Of | analyse,be |
R6966 | T10368 | T10366 | arg1Of | analyse,interesting |
R6967 | T10368 | T10367 | arg1Of | analyse,to |
R6968 | T10368 | T10369 | arg1Of | analyse,in |
R6969 | T10370 | T10375 | arg1Of | future,knockout |
R6970 | T10375 | T10371 | arg1Of | knockout,the |
R6971 | T10375 | T10372 | arg1Of | knockout,susceptibility |
R6972 | T10375 | T10373 | arg1Of | knockout,of |
R6973 | T10375 | T10374 | arg1Of | knockout,conditional |
R6974 | T10376 | T10369 | arg2Of | mice,in |
R6975 | T10376 | T10370 | arg1Of | mice,future |
R6976 | T10377 | T10368 | arg2Of | that,analyse |
R6977 | T10377 | T10378 | arg1Of | that,lack |
R6978 | T10378 | T10380 | arg1Of | lack,in |
R6979 | T10379 | T10378 | arg2Of | A20,lack |
R6980 | T10383 | T10381 | arg1Of | types,specific |
R6981 | T10383 | T10382 | arg1Of | types,cell |
R6982 | T10383 | T10385 | arg1Of | types,as |
R6983 | T10383 | T10393 | arg1Of | types,"," |
R6984 | T10385 | T10384 | arg1Of | as,such |
R6985 | T10387 | T10386 | arg1Of | fibroblasts,synovial |
R6986 | T10387 | T10388 | arg1Of | fibroblasts,"," |
R6987 | T10388 | T10390 | arg1Of | ",","," |
R6988 | T10389 | T10388 | arg2Of | macrophages,"," |
R6989 | T10390 | T10385 | arg2Of | ",",as |
R6990 | T10392 | T10390 | arg2Of | cells,"," |
R6991 | T10392 | T10391 | arg1Of | cells,dendritic |
R6992 | T10393 | T10396 | arg1Of | ",",or |
R6993 | T10395 | T10393 | arg2Of | cells,"," |
R6994 | T10395 | T10394 | arg1Of | cells,B |
R6995 | T10396 | T10380 | arg2Of | or,in |
R6996 | T10398 | T10396 | arg2Of | cells,or |
R6997 | T10398 | T10397 | arg1Of | cells,T |
R6998 | T10402 | T10401 | arg1Of | SNPs,several |
R6999 | T10402 | T10403 | arg1Of | SNPs,in |
R7000 | T10402 | T10408 | arg1Of | SNPs,have |
R7001 | T10402 | T10409 | arg1Of | SNPs,been |
R7002 | T10402 | T10410 | arg2Of | SNPs,associated |
R7003 | T10407 | T10403 | arg2Of | locus,in |
R7004 | T10407 | T10404 | arg1Of | locus,the |
R7005 | T10407 | T10405 | arg1Of | locus,human |
R7006 | T10407 | T10406 | arg1Of | locus,A20 |
R7007 | T10410 | T10399 | arg1Of | associated,Importantly |
R7008 | T10410 | T10400 | arg1Of | associated,"," |
R7009 | T10410 | T10408 | arg2Of | associated,have |
R7010 | T10410 | T10409 | arg2Of | associated,been |
R7011 | T10410 | T10411 | arg1Of | associated,with |
R7012 | T10413 | T10411 | arg2Of | susceptibility,with |
R7013 | T10413 | T10412 | arg2Of | susceptibility,increased |
R7014 | T10413 | T10414 | arg1Of | susceptibility,to |
R7015 | T10415 | T10414 | arg2Of | development,to |
R7016 | T10415 | T10416 | arg1Of | development,of |
R7017 | T10415 | T10419 | arg1Of | development,( |
R7018 | T10418 | T10416 | arg2Of | pathologies,of |
R7019 | T10418 | T10417 | arg1Of | pathologies,autoimmune |
R7020 | T10420 | T10419 | arg2Of | reviewed,( |
R7021 | T10420 | T10421 | arg1Of | reviewed,in |
R7022 | T10420 | T10422 | arg1Of | reviewed,[ |
R7023 | T10423 | T10422 | arg2Of | 52,[ |
R7024 | T10424 | T10422 | arg3Of | ],[ |
R7025 | T10425 | T10419 | arg3Of | ),( |
R7026 | T10429 | T10426 | arg1Of | studies,Several |
R7027 | T10429 | T10427 | arg1Of | studies,genome-wide |
R7028 | T10429 | T10428 | arg1Of | studies,association |
R7029 | T10429 | T10431 | arg1Of | studies,revealed |
R7030 | T10431 | T10430 | arg1Of | revealed,also |
R7031 | T10434 | T10432 | arg1Of | association,a |
R7032 | T10434 | T10433 | arg1Of | association,clear |
R7033 | T10434 | T10435 | arg1Of | association,between |
R7034 | T10434 | T10445 | arg1Of | association,and |
R7035 | T10436 | T10435 | arg2Of | mutations,between |
R7036 | T10436 | T10437 | arg1Of | mutations,in |
R7037 | T10440 | T10437 | arg2Of | locus,in |
R7038 | T10440 | T10438 | arg1Of | locus,the |
R7039 | T10440 | T10439 | arg1Of | locus,A20 |
R7040 | T10440 | T10441 | arg1Of | locus,in |
R7041 | T10444 | T10441 | arg2Of | chromosome,in |
R7042 | T10444 | T10442 | arg1Of | chromosome,the |
R7043 | T10444 | T10443 | arg1Of | chromosome,6q23 |
R7044 | T10445 | T10431 | arg2Of | and,revealed |
R7045 | T10446 | T10445 | arg2Of | susceptibility,and |
R7046 | T10446 | T10447 | arg1Of | susceptibility,to |
R7047 | T10448 | T10447 | arg2Of | RA,to |
R7048 | T10448 | T10449 | arg1Of | RA,[ |
R7049 | T10450 | T10449 | arg2Of | 52,[ |
R7050 | T10451 | T10449 | arg3Of | ],[ |
R7051 | T10455 | T10453 | arg1Of | variants,the |
R7052 | T10455 | T10454 | arg2Of | variants,identified |
R7053 | T10455 | T10456 | arg1Of | variants,are |
R7054 | T10455 | T10458 | arg2Of | variants,located |
R7055 | T10458 | T10452 | arg2Of | located,Although |
R7056 | T10458 | T10456 | arg2Of | located,are |
R7057 | T10458 | T10457 | arg1Of | located,not |
R7058 | T10458 | T10459 | arg1Of | located,in |
R7059 | T10461 | T10459 | arg2Of | gene,in |
R7060 | T10461 | T10460 | arg1Of | gene,a |
R7061 | T10463 | T10464 | arg1Of | they,are |
R7062 | T10463 | T10465 | arg2Of | they,thought |
R7063 | T10463 | T10467 | arg1Of | they,influence |
R7064 | T10465 | T10452 | arg1Of | thought,Although |
R7065 | T10465 | T10462 | arg1Of | thought,"," |
R7066 | T10465 | T10464 | arg2Of | thought,are |
R7067 | T10467 | T10465 | arg3Of | influence,thought |
R7068 | T10467 | T10466 | arg1Of | influence,to |
R7069 | T10467 | T10469 | arg1Of | influence,as |
R7070 | T10467 | T10480 | arg1Of | influence,"," |
R7071 | T10467 | T10482 | arg1Of | influence,by |
R7072 | T10468 | T10467 | arg2Of | A20,influence |
R7073 | T10472 | T10469 | arg2Of | gene,as |
R7074 | T10472 | T10470 | arg1Of | gene,its |
R7075 | T10472 | T10471 | arg1Of | gene,nearest |
R7076 | T10472 | T10473 | arg1Of | gene,( |
R7077 | T10475 | T10473 | arg2Of | kb,( |
R7078 | T10475 | T10474 | arg1Of | kb,~150 |
R7079 | T10475 | T10476 | arg1Of | kb,downstream |
R7080 | T10476 | T10477 | arg1Of | downstream,of |
R7081 | T10478 | T10477 | arg2Of | A20,of |
R7082 | T10479 | T10473 | arg3Of | ),( |
R7083 | T10482 | T10481 | arg1Of | by,probably |
R7084 | T10484 | T10482 | arg2Of | presence,by |
R7085 | T10484 | T10483 | arg1Of | presence,the |
R7086 | T10484 | T10485 | arg1Of | presence,of |
R7087 | T10489 | T10485 | arg2Of | elements,of |
R7088 | T10489 | T10486 | arg1Of | elements,potential |
R7089 | T10489 | T10487 | arg1Of | elements,regulatory |
R7090 | T10489 | T10488 | arg1Of | elements,DNA |
R7091 | T10489 | T10490 | arg1Of | elements,in |
R7092 | T10492 | T10490 | arg2Of | region,in |
R7093 | T10492 | T10491 | arg1Of | region,this |
R7094 | T10494 | T10495 | arg1Of | A20,is |
R7095 | T10494 | T10496 | arg2Of | A20,required |
R7096 | T10496 | T10495 | arg2Of | required,is |
R7097 | T10496 | T10497 | arg1Of | required,for |
R7098 | T10496 | T10503 | arg1Of | required,and |
R7099 | T10498 | T10497 | arg2Of | termination,for |
R7100 | T10498 | T10499 | arg1Of | termination,of |
R7101 | T10501 | T10499 | arg2Of | signals,of |
R7102 | T10501 | T10500 | arg1Of | signals,TNF-induced |
R7103 | T10503 | T10493 | arg2Of | and,As |
R7104 | T10503 | T10502 | arg1Of | and,"," |
R7105 | T10504 | T10505 | arg1Of | TNF,is |
R7106 | T10505 | T10503 | arg2Of | is,and |
R7107 | T10509 | T10505 | arg2Of | cytokine,is |
R7108 | T10509 | T10506 | arg1Of | cytokine,the |
R7109 | T10509 | T10507 | arg1Of | cytokine,primary |
R7110 | T10509 | T10508 | arg1Of | cytokine,inflammatory |
R7111 | T10509 | T10510 | arg1Of | cytokine,in |
R7112 | T10511 | T10510 | arg2Of | RA,in |
R7113 | T10514 | T10513 | arg1Of | findings,these |
R7114 | T10514 | T10515 | arg1Of | findings,reveal |
R7115 | T10515 | T10493 | arg1Of | reveal,As |
R7116 | T10515 | T10512 | arg1Of | reveal,"," |
R7117 | T10515 | T10517 | arg1Of | reveal,as |
R7118 | T10516 | T10515 | arg2Of | A20,reveal |
R7119 | T10521 | T10517 | arg2Of | locus,as |
R7120 | T10521 | T10518 | arg1Of | locus,a |
R7121 | T10521 | T10519 | arg1Of | locus,candidate |
R7122 | T10521 | T10520 | arg1Of | locus,susceptibility |
R7123 | T10521 | T10522 | arg1Of | locus,for |
R7124 | T10523 | T10522 | arg2Of | RA,for |
R7125 | T10526 | T10525 | arg1Of | variants,these |
R7126 | T10526 | T10527 | arg1Of | variants,affect |
R7127 | T10526 | T10539 | arg1Of | variants,remain |
R7128 | T10526 | T10540 | arg1Of | variants,unclear |
R7129 | T10527 | T10536 | arg1Of | affect,"," |
R7130 | T10530 | T10528 | arg1Of | activity,normal |
R7131 | T10530 | T10529 | arg1Of | activity,A20 |
R7132 | T10530 | T10531 | arg1Of | activity,and |
R7133 | T10531 | T10527 | arg2Of | and,affect |
R7134 | T10532 | T10531 | arg2Of | how,and |
R7135 | T10533 | T10534 | arg1Of | they,cause |
R7136 | T10534 | T10532 | arg1Of | cause,how |
R7137 | T10535 | T10534 | arg2Of | RA,cause |
R7138 | T10536 | T10524 | arg1Of | ",",How |
R7139 | T10539 | T10536 | arg2Of | remain,"," |
R7140 | T10539 | T10537 | arg1Of | remain,however |
R7141 | T10539 | T10538 | arg1Of | remain,"," |
R7142 | T10540 | T10539 | arg2Of | unclear,remain |
R7143 | T10543 | T10544 | arg1Of | Elsby,and |
R7144 | T10544 | T10547 | arg1Of | and,evaluated |
R7145 | T10544 | T10563 | arg1Of | and,could |
R7146 | T10544 | T10564 | arg1Of | and,show |
R7147 | T10545 | T10544 | arg2Of | colleagues,and |
R7148 | T10547 | T10549 | arg1Of | evaluated,vitro |
R7149 | T10547 | T10562 | arg1Of | evaluated,and |
R7150 | T10549 | T10548 | arg1Of | vitro,in |
R7151 | T10552 | T10547 | arg2Of | ability,evaluated |
R7152 | T10552 | T10550 | arg1Of | ability,the |
R7153 | T10552 | T10551 | arg1Of | ability,regulatory |
R7154 | T10552 | T10553 | arg1Of | ability,of |
R7155 | T10552 | T10557 | arg1Of | ability,on |
R7156 | T10556 | T10553 | arg2Of | variants,of |
R7157 | T10556 | T10554 | arg1Of | variants,RA-associated |
R7158 | T10556 | T10555 | arg1Of | variants,SNP |
R7159 | T10560 | T10557 | arg2Of | activity,on |
R7160 | T10560 | T10558 | arg1Of | activity,A20 |
R7161 | T10560 | T10559 | arg1Of | activity,promoter |
R7162 | T10562 | T10541 | arg1Of | and,Recently |
R7163 | T10562 | T10542 | arg1Of | and,"," |
R7164 | T10562 | T10546 | arg1Of | and,functionally |
R7165 | T10562 | T10561 | arg1Of | and,"," |
R7166 | T10564 | T10562 | arg2Of | show,and |
R7167 | T10564 | T10563 | arg2Of | show,could |
R7168 | T10567 | T10564 | arg2Of | transcription,show |
R7169 | T10567 | T10565 | arg2Of | transcription,repressed |
R7170 | T10567 | T10566 | arg1Of | transcription,A20 |
R7171 | T10567 | T10568 | arg1Of | transcription,for |
R7172 | T10569 | T10568 | arg2Of | some,for |
R7173 | T10569 | T10570 | arg1Of | some,of |
R7174 | T10572 | T10570 | arg2Of | SNPs,of |
R7175 | T10572 | T10571 | arg1Of | SNPs,the |
R7176 | T10572 | T10573 | arg2Of | SNPs,investigated |
R7177 | T10573 | T10574 | arg1Of | investigated,[ |
R7178 | T10575 | T10574 | arg2Of | 53,[ |
R7179 | T10576 | T10574 | arg3Of | ],[ |
R7180 | T10577 | T10578 | arg1Of | It,will |
R7181 | T10577 | T10579 | arg1Of | It,be |
R7182 | T10577 | T10580 | arg1Of | It,of |
R7183 | T10579 | T10578 | arg2Of | be,will |
R7184 | T10579 | T10582 | modOf | be,to |
R7185 | T10579 | T10589 | modOf | be,to |
R7186 | T10580 | T10579 | arg2Of | of,be |
R7187 | T10581 | T10580 | arg2Of | interest,of |
R7188 | T10583 | T10582 | arg1Of | identify,to |
R7189 | T10583 | T10588 | arg1Of | identify,and |
R7190 | T10587 | T10583 | arg2Of | variants,identify |
R7191 | T10587 | T10584 | arg1Of | variants,the |
R7192 | T10587 | T10585 | arg1Of | variants,actual |
R7193 | T10587 | T10586 | arg1Of | variants,causal |
R7194 | T10590 | T10588 | arg2Of | elucidate,and |
R7195 | T10590 | T10589 | arg1Of | elucidate,to |
R7196 | T10593 | T10590 | arg2Of | consequences,elucidate |
R7197 | T10593 | T10591 | arg1Of | consequences,the |
R7198 | T10593 | T10592 | arg1Of | consequences,functional |
R7199 | T10593 | T10594 | arg1Of | consequences,of |
R7200 | T10596 | T10594 | arg2Of | variants,of |
R7201 | T10596 | T10595 | arg1Of | variants,these |
R7202 | T10599 | T10597 | arg2Of | context,In |
R7203 | T10599 | T10598 | arg1Of | context,this |
R7204 | T10602 | T10601 | arg1Of | mice,knockin |
R7205 | T10602 | T10603 | arg1Of | mice,for |
R7206 | T10602 | T10616 | arg1Of | mice,will |
R7207 | T10602 | T10617 | arg1Of | mice,be |
R7208 | T10607 | T10603 | arg2Of | SNPs,for |
R7209 | T10607 | T10604 | arg1Of | SNPs,the |
R7210 | T10607 | T10605 | arg1Of | SNPs,corresponding |
R7211 | T10607 | T10606 | arg1Of | SNPs,A20 |
R7212 | T10607 | T10608 | arg1Of | SNPs,"," |
R7213 | T10607 | T10609 | arg2Of | SNPs,combined |
R7214 | T10609 | T10610 | arg1Of | combined,with |
R7215 | T10612 | T10610 | arg2Of | models,with |
R7216 | T10612 | T10611 | arg1Of | models,mouse |
R7217 | T10612 | T10613 | arg1Of | models,for |
R7218 | T10614 | T10613 | arg2Of | RA,for |
R7219 | T10617 | T10597 | arg1Of | be,In |
R7220 | T10617 | T10600 | arg1Of | be,"," |
R7221 | T10617 | T10615 | arg1Of | be,"," |
R7222 | T10617 | T10616 | arg2Of | be,will |
R7223 | T10619 | T10618 | arg1Of | valuable,very |
R7224 | T10620 | T10617 | arg2Of | tools,be |
R8366 | T12738 | T12737 | arg1Of | inhibitors,A20-binding |
R8367 | T12738 | T12739 | arg1Of | inhibitors,of |
R8368 | T12740 | T12739 | arg2Of | NF-κB,of |
R8369 | T12741 | T12742 | arg1Of | ABIN-1,"," |
R8370 | T12742 | T12744 | arg1Of | ",",and |
R8371 | T12743 | T12742 | arg2Of | ABIN-2,"," |
R8372 | T12744 | T12746 | arg1Of | and,( |
R8373 | T12744 | T12757 | arg1Of | and,were |
R8374 | T12744 | T12758 | arg2Of | and,identified |
R8375 | T12744 | T12766 | arg1Of | and,were |
R8376 | T12744 | T12767 | arg2Of | and,shown |
R8377 | T12744 | T12769 | arg1Of | and,inhibit |
R8378 | T12745 | T12744 | arg2Of | ABIN-3,and |
R8379 | T12748 | T12746 | arg2Of | known,( |
R8380 | T12748 | T12747 | arg1Of | known,also |
R8381 | T12748 | T12749 | arg1Of | known,as |
R8382 | T12750 | T12751 | arg1Of | TNIP-1,"," |
R8383 | T12751 | T12754 | arg1Of | ",",and |
R8384 | T12752 | T12751 | arg2Of | TNIP-2,"," |
R8385 | T12754 | T12749 | arg2Of | and,as |
R8386 | T12754 | T12753 | arg1Of | and,"," |
R8387 | T12755 | T12754 | arg2Of | TNIP-3,and |
R8388 | T12756 | T12746 | arg3Of | ),( |
R8389 | T12758 | T12757 | arg2Of | identified,were |
R8390 | T12758 | T12759 | arg1Of | identified,as |
R8391 | T12758 | T12765 | arg1Of | identified,and |
R8392 | T12761 | T12760 | arg1Of | expressed,ubiquitously |
R8393 | T12764 | T12759 | arg2Of | proteins,as |
R8394 | T12764 | T12761 | arg1Of | proteins,expressed |
R8395 | T12764 | T12762 | arg1Of | proteins,A20 |
R8396 | T12764 | T12763 | arg1Of | proteins,interacting |
R8397 | T12767 | T12765 | arg2Of | shown,and |
R8398 | T12767 | T12766 | arg2Of | shown,were |
R8399 | T12769 | T12767 | arg3Of | inhibit,shown |
R8400 | T12769 | T12768 | arg1Of | inhibit,to |
R8401 | T12771 | T12769 | arg2Of | activation,inhibit |
R8402 | T12771 | T12770 | arg1Of | activation,NF-κB |
R8403 | T12771 | T12772 | arg1Of | activation,by |
R8404 | T12771 | T12779 | arg1Of | activation,upon |
R8405 | T12773 | T12774 | arg1Of | TNF,and |
R8406 | T12777 | T12774 | arg2Of | inflammatory,and |
R8407 | T12777 | T12775 | arg1Of | inflammatory,several |
R8408 | T12777 | T12776 | arg1Of | inflammatory,other |
R8409 | T12778 | T12772 | arg2Of | stimuli,by |
R8410 | T12778 | T12773 | arg1Of | stimuli,TNF |
R8411 | T12778 | T12777 | arg1Of | stimuli,inflammatory |
R8412 | T12780 | T12779 | arg2Of | overexpression,upon |
R8413 | T12782 | T12783 | arg1Of | ABINs,contain |
R8414 | T12783 | T12781 | arg2Of | contain,Because |
R8415 | T12787 | T12783 | arg2Of | motif,contain |
R8416 | T12787 | T12784 | arg1Of | motif,a |
R8417 | T12787 | T12785 | arg1Of | motif,specific |
R8418 | T12787 | T12786 | arg1Of | motif,ubiquitin-binding |
R8419 | T12789 | T12790 | arg1Of | they,have |
R8420 | T12789 | T12791 | arg1Of | they,been |
R8421 | T12789 | T12792 | arg2Of | they,proposed |
R8422 | T12789 | T12794 | arg1Of | they,target |
R8423 | T12792 | T12781 | arg1Of | proposed,Because |
R8424 | T12792 | T12788 | arg1Of | proposed,"," |
R8425 | T12792 | T12790 | arg2Of | proposed,have |
R8426 | T12792 | T12791 | arg2Of | proposed,been |
R8427 | T12794 | T12792 | arg3Of | target,proposed |
R8428 | T12794 | T12793 | arg1Of | target,to |
R8429 | T12795 | T12794 | arg2Of | A20,target |
R8430 | T12795 | T12796 | arg1Of | A20,to |
R8431 | T12798 | T12796 | arg2Of | substrates,to |
R8432 | T12798 | T12797 | arg2Of | substrates,polyubiquitinated |
R8433 | T12798 | T12799 | arg1Of | substrates,[ |
R8434 | T12800 | T12799 | arg2Of | "43,44",[ |
R8435 | T12801 | T12799 | arg3Of | ],[ |
R8436 | T12802 | T12803 | arg1Of | Similar,to |
R8437 | T12804 | T12803 | arg2Of | A20,to |
R8438 | T12806 | T12807 | arg1Of | ABIN-1,and |
R8439 | T12807 | T12810 | arg1Of | and,is |
R8440 | T12809 | T12807 | arg2Of | expression,and |
R8441 | T12809 | T12808 | arg1Of | expression,ABIN-3 |
R8442 | T12810 | T12802 | arg1Of | is,Similar |
R8443 | T12810 | T12805 | arg1Of | is,"," |
R8444 | T12810 | T12813 | arg1Of | is,"," |
R8445 | T12810 | T12814 | modOf | is,implicating |
R8446 | T12811 | T12810 | arg2Of | NF-κB,is |
R8447 | T12811 | T12812 | arg1Of | NF-κB,dependent |
R8448 | T12817 | T12814 | arg2Of | role,implicating |
R8449 | T12817 | T12815 | arg1Of | role,a |
R8450 | T12817 | T12816 | arg1Of | role,potential |
R8451 | T12817 | T12818 | arg1Of | role,for |
R8452 | T12817 | T12822 | arg1Of | role,in |
R8453 | T12821 | T12818 | arg2Of | complex,for |
R8454 | T12821 | T12819 | arg1Of | complex,the |
R8455 | T12821 | T12820 | arg1Of | complex,A20/ABIN |
R8456 | T12826 | T12822 | arg2Of | regulation,in |
R8457 | T12826 | T12823 | arg1Of | regulation,the |
R8458 | T12826 | T12824 | arg1Of | regulation,negative |
R8459 | T12826 | T12825 | arg1Of | regulation,feedback |
R8460 | T12826 | T12827 | arg1Of | regulation,of |
R8461 | T12826 | T12830 | arg1Of | regulation,( |
R8462 | T12829 | T12827 | arg2Of | activation,of |
R8463 | T12829 | T12828 | arg1Of | activation,NF-κB |
R8464 | T12831 | T12830 | arg2Of | reviewed,( |
R8465 | T12831 | T12832 | arg1Of | reviewed,in |
R8466 | T12831 | T12833 | arg1Of | reviewed,[ |
R8467 | T12834 | T12833 | arg2Of | 54,[ |
R8468 | T12835 | T12833 | arg3Of | ],[ |
R8469 | T12836 | T12830 | arg3Of | ),( |
R8470 | T12840 | T12841 | arg1Of | ABIN-1-deficient,and |
R8471 | T12842 | T12841 | arg2Of | ABIN-2-deficient,and |
R8472 | T12843 | T12839 | arg1Of | mice,both |
R8473 | T12843 | T12840 | arg1Of | mice,ABIN-1-deficient |
R8474 | T12843 | T12842 | arg1Of | mice,ABIN-2-deficient |
R8475 | T12843 | T12844 | arg1Of | mice,exhibit |
R8476 | T12843 | T12856 | arg1Of | mice,reflecting |
R8477 | T12844 | T12837 | arg1Of | exhibit,Unexpectedly |
R8478 | T12844 | T12838 | arg1Of | exhibit,"," |
R8479 | T12844 | T12846 | arg1Of | exhibit,slightly |
R8480 | T12844 | T12852 | arg1Of | exhibit,"," |
R8481 | T12844 | T12853 | arg1Of | exhibit,respectively |
R8482 | T12844 | T12854 | arg1Of | exhibit,"," |
R8483 | T12844 | T12856 | modOf | exhibit,reflecting |
R8484 | T12846 | T12845 | arg1Of | slightly,only |
R8485 | T12847 | T12848 | arg1Of | increased,or |
R8486 | T12849 | T12848 | arg2Of | normal,or |
R8487 | T12851 | T12844 | arg2Of | responses,exhibit |
R8488 | T12851 | T12847 | arg1Of | responses,increased |
R8489 | T12851 | T12849 | arg1Of | responses,normal |
R8490 | T12851 | T12850 | arg1Of | responses,NF-κB |
R8491 | T12856 | T12855 | arg1Of | reflecting,possibly |
R8492 | T12860 | T12856 | arg2Of | activities,reflecting |
R8493 | T12860 | T12857 | arg1Of | activities,redundant |
R8494 | T12860 | T12858 | arg1Of | activities,NF-κB |
R8495 | T12860 | T12859 | arg1Of | activities,inhibitory |
R8496 | T12860 | T12861 | arg1Of | activities,of |
R8497 | T12863 | T12861 | arg2Of | ABINs,of |
R8498 | T12863 | T12862 | arg1Of | ABINs,multiple |
R8499 | T12863 | T12864 | arg1Of | ABINs,[ |
R8500 | T12865 | T12864 | arg2Of | "55,56",[ |
R8501 | T12866 | T12864 | arg3Of | ],[ |
R8502 | T12868 | T12867 | arg1Of | ABIN-3,Functional |
R8503 | T12868 | T12869 | arg1Of | ABIN-3,is |
R8504 | T12868 | T12870 | arg2Of | ABIN-3,expressed |
R8505 | T12870 | T12869 | arg2Of | expressed,is |
R8506 | T12870 | T12871 | arg1Of | expressed,in |
R8507 | T12870 | T12874 | arg1Of | expressed,but |
R8508 | T12872 | T12871 | arg2Of | humans,in |
R8509 | T12874 | T12873 | arg1Of | but,"," |
R8510 | T12875 | T12877 | arg1Of | mice,express |
R8511 | T12877 | T12874 | arg2Of | express,but |
R8512 | T12877 | T12876 | arg1Of | express,only |
R8513 | T12879 | T12880 | arg1Of | truncated,and |
R8514 | T12881 | T12880 | arg2Of | inactive,and |
R8515 | T12882 | T12877 | arg2Of | form,express |
R8516 | T12882 | T12878 | arg1Of | form,a |
R8517 | T12882 | T12879 | arg1Of | form,truncated |
R8518 | T12882 | T12881 | arg1Of | form,inactive |
R8519 | T12882 | T12883 | arg1Of | form,lacking |
R8520 | T12887 | T12883 | arg2Of | domain,lacking |
R8521 | T12887 | T12884 | arg1Of | domain,the |
R8522 | T12887 | T12885 | arg1Of | domain,crucial |
R8523 | T12887 | T12886 | arg1Of | domain,ubiquitin-binding |
R8524 | T12887 | T12888 | arg1Of | domain,[ |
R8525 | T12889 | T12888 | arg2Of | 57,[ |
R8526 | T12890 | T12888 | arg3Of | ],[ |
R8527 | T12892 | T12891 | arg1Of | for,As |
R8528 | T12893 | T12892 | arg2Of | A20,for |
R8529 | T12895 | T12898 | arg1Of | ABIN-1,inhibits |
R8530 | T12898 | T12896 | arg1Of | inhibits,also |
R8531 | T12898 | T12897 | arg1Of | inhibits,strongly |
R8532 | T12898 | T12905 | arg1Of | inhibits,and |
R8533 | T12900 | T12898 | arg2Of | apoptosis,inhibits |
R8534 | T12900 | T12899 | arg1Of | apoptosis,TNF-induced |
R8535 | T12900 | T12901 | arg1Of | apoptosis,[ |
R8536 | T12902 | T12901 | arg2Of | 58,[ |
R8537 | T12903 | T12901 | arg3Of | ],[ |
R8538 | T12905 | T12892 | arg1Of | and,for |
R8539 | T12905 | T12894 | arg1Of | and,"," |
R8540 | T12905 | T12904 | arg1Of | and,"," |
R8541 | T12908 | T12906 | arg1Of | mice,ABIN-1 |
R8542 | T12908 | T12907 | arg1Of | mice,deficient |
R8543 | T12908 | T12909 | arg1Of | mice,die |
R8544 | T12909 | T12905 | arg2Of | die,and |
R8545 | T12909 | T12910 | arg1Of | die,embryonically |
R8546 | T12909 | T12917 | arg1Of | die,[ |
R8547 | T12910 | T12912 | arg1Of | embryonically,to |
R8548 | T12912 | T12911 | arg1Of | to,due |
R8549 | T12916 | T12912 | arg2Of | apoptosis,to |
R8550 | T12916 | T12913 | arg1Of | apoptosis,TNF-dependent |
R8551 | T12916 | T12914 | arg1Of | apoptosis,foetal |
R8552 | T12916 | T12915 | arg1Of | apoptosis,liver |
R8553 | T12918 | T12917 | arg2Of | 56,[ |
R8554 | T12919 | T12917 | arg3Of | ],[ |
R8555 | T12923 | T12920 | arg2Of | analysis,Using |
R8556 | T12923 | T12921 | arg1Of | analysis,oligonucleotide |
R8557 | T12923 | T12922 | arg1Of | analysis,microarray |
R8558 | T12925 | T12920 | arg1Of | ABIN-1,Using |
R8559 | T12925 | T12926 | arg1Of | ABIN-1,was |
R8560 | T12925 | T12927 | arg2Of | ABIN-1,identified |
R8561 | T12927 | T12926 | arg2Of | identified,was |
R8562 | T12927 | T12928 | arg1Of | identified,among |
R8563 | T12927 | T12931 | arg1Of | identified,in |
R8564 | T12927 | T12935 | arg1Of | identified,and |
R8565 | T12930 | T12928 | arg2Of | genes,among |
R8566 | T12930 | T12929 | arg1Of | genes,TNF-induced |
R8567 | T12933 | T12931 | arg2Of | synoviocytes,in |
R8568 | T12933 | T12932 | arg1Of | synoviocytes,human |
R8569 | T12935 | T12920 | modOf | and,Using |
R8570 | T12935 | T12924 | arg1Of | and,"," |
R8571 | T12935 | T12934 | arg1Of | and,"," |
R8572 | T12937 | T12936 | arg1Of | levels,high |
R8573 | T12937 | T12938 | arg1Of | levels,of |
R8574 | T12937 | T12941 | arg1Of | levels,were |
R8575 | T12937 | T12942 | arg2Of | levels,detected |
R8576 | T12940 | T12938 | arg2Of | mRNA,of |
R8577 | T12940 | T12939 | arg1Of | mRNA,ABIN-1 |
R8578 | T12942 | T12935 | arg2Of | detected,and |
R8579 | T12942 | T12941 | arg2Of | detected,were |
R8580 | T12942 | T12943 | arg1Of | detected,in |
R8581 | T12942 | T12947 | arg1Of | detected,"," |
R8582 | T12942 | T12948 | modOf | detected,indicating |
R8583 | T12946 | T12943 | arg2Of | biopsies,in |
R8584 | T12946 | T12944 | arg1Of | biopsies,RA |
R8585 | T12946 | T12945 | arg1Of | biopsies,tissue |
R8586 | T12951 | T12948 | arg2Of | role,indicating |
R8587 | T12951 | T12949 | arg1Of | role,a |
R8588 | T12951 | T12950 | arg1Of | role,potential |
R8589 | T12951 | T12952 | arg1Of | role,for |
R8590 | T12951 | T12956 | arg1Of | role,with |
R8591 | T12951 | T12958 | arg1Of | role,"," |
R8592 | T12951 | T12959 | arg1Of | role,in |
R8593 | T12952 | T12954 | arg1Of | for,"," |
R8594 | T12953 | T12952 | arg2Of | ABIN-1,for |
R8595 | T12956 | T12954 | arg2Of | with,"," |
R8596 | T12956 | T12955 | arg1Of | with,together |
R8597 | T12957 | T12956 | arg2Of | A20,with |
R8598 | T12963 | T12960 | arg1Of | regulation,the |
R8599 | T12963 | T12961 | arg1Of | regulation,negative |
R8600 | T12963 | T12962 | arg1Of | regulation,feedback |
R8601 | T12963 | T12964 | arg1Of | regulation,of |
R8602 | T12963 | T12967 | arg1Of | regulation,and |
R8603 | T12966 | T12964 | arg2Of | signalling,of |
R8604 | T12966 | T12965 | arg1Of | signalling,NF-κB |
R8605 | T12967 | T12959 | arg2Of | and,in |
R8606 | T12969 | T12967 | arg2Of | pathogenesis,and |
R8607 | T12969 | T12968 | arg1Of | pathogenesis,the |
R8608 | T12969 | T12970 | arg1Of | pathogenesis,of |
R8609 | T12971 | T12970 | arg2Of | RA,of |
R8610 | T12971 | T12972 | arg1Of | RA,[ |
R8611 | T12973 | T12972 | arg2Of | 59,[ |
R8612 | T12974 | T12972 | arg3Of | ],[ |
R8613 | T12978 | T12975 | arg2Of | study,In |
R8614 | T12978 | T12976 | arg1Of | study,a |
R8615 | T12978 | T12977 | arg1Of | study,recent |
R8616 | T12980 | T12981 | arg1Of | inhibition,of |
R8617 | T12980 | T12984 | arg1Of | inhibition,by |
R8618 | T12980 | T12994 | arg1Of | inhibition,was |
R8619 | T12980 | T12995 | arg2Of | inhibition,shown |
R8620 | T12980 | T12997 | arg1Of | inhibition,depend |
R8621 | T12983 | T12981 | arg2Of | responses,of |
R8622 | T12983 | T12982 | arg1Of | responses,TLR |
R8623 | T12990 | T12989 | arg2Of | ITAM,( |
R8624 | T12991 | T12989 | arg3Of | ),( |
R8625 | T12993 | T12984 | arg2Of | receptors,by |
R8626 | T12993 | T12985 | arg1Of | receptors,immunoreceptor |
R8627 | T12993 | T12986 | arg1Of | receptors,tyrosine-based |
R8628 | T12993 | T12987 | arg1Of | receptors,activation |
R8629 | T12993 | T12988 | arg1Of | receptors,motif |
R8630 | T12993 | T12989 | arg1Of | receptors,( |
R8631 | T12993 | T12992 | arg1Of | receptors,-coupled |
R8632 | T12995 | T12975 | arg1Of | shown,In |
R8633 | T12995 | T12979 | arg1Of | shown,"," |
R8634 | T12995 | T12994 | arg2Of | shown,was |
R8635 | T12997 | T12995 | arg3Of | depend,shown |
R8636 | T12997 | T12996 | arg1Of | depend,to |
R8637 | T12997 | T12998 | arg1Of | depend,on |
R8638 | T13000 | T12998 | arg2Of | expression,on |
R8639 | T13000 | T12999 | arg1Of | expression,the |
R8640 | T13000 | T13001 | arg1Of | expression,of |
R8641 | T13005 | T13002 | arg1Of | proteins,the |
R8642 | T13005 | T13003 | arg1Of | proteins,NF-κB |
R8643 | T13005 | T13004 | arg1Of | proteins,inhibitory |
R8644 | T13006 | T13007 | arg1Of | ABIN-3,and |
R8645 | T13007 | T13001 | arg2Of | and,of |
R8646 | T13007 | T13005 | arg1Of | and,proteins |
R8647 | T13008 | T13007 | arg2Of | A20,and |
R8648 | T13013 | T13011 | arg1Of | effect,this |
R8649 | T13013 | T13012 | arg1Of | effect,protective |
R8650 | T13013 | T13014 | arg1Of | effect,of |
R8651 | T13013 | T13017 | arg1Of | effect,was |
R8652 | T13013 | T13019 | arg2Of | effect,suppressed |
R8653 | T13016 | T13014 | arg2Of | ITAM,of |
R8654 | T13016 | T13015 | arg1Of | ITAM,the |
R8655 | T13019 | T13009 | arg1Of | suppressed,Moreover |
R8656 | T13019 | T13010 | arg1Of | suppressed,"," |
R8657 | T13019 | T13017 | arg2Of | suppressed,was |
R8658 | T13019 | T13018 | arg1Of | suppressed,strongly |
R8659 | T13019 | T13020 | arg1Of | suppressed,in |
R8660 | T13024 | T13020 | arg2Of | macrophages,in |
R8661 | T13024 | T13021 | arg1Of | macrophages,inflammatory |
R8662 | T13024 | T13022 | arg1Of | macrophages,arthritis |
R8663 | T13024 | T13023 | arg1Of | macrophages,synovial |
R8664 | T13024 | T13025 | arg1Of | macrophages,[ |
R8665 | T13026 | T13025 | arg2Of | 60,[ |
R8666 | T13027 | T13025 | arg3Of | ],[ |
R8667 | T13031 | T13030 | arg1Of | polymorphisms,ABIN-1 |
R8668 | T13031 | T13032 | arg1Of | polymorphisms,have |
R8669 | T13031 | T13033 | arg1Of | polymorphisms,been |
R8670 | T13031 | T13034 | arg2Of | polymorphisms,associated |
R8671 | T13034 | T13028 | arg1Of | associated,Interestingly |
R8672 | T13034 | T13029 | arg1Of | associated,"," |
R8673 | T13034 | T13032 | arg2Of | associated,have |
R8674 | T13034 | T13033 | arg2Of | associated,been |
R8675 | T13034 | T13035 | arg1Of | associated,with |
R8676 | T13036 | T13037 | arg1Of | psoriasis,and |
R8677 | T13037 | T13035 | arg2Of | and,with |
R8678 | T13037 | T13041 | arg1Of | and,in |
R8679 | T13040 | T13037 | arg2Of | erythematosus,and |
R8680 | T13040 | T13038 | arg1Of | erythematosus,systemic |
R8681 | T13040 | T13039 | arg1Of | erythematosus,lupus |
R8682 | T13042 | T13041 | arg2Of | humans,in |
R8683 | T13042 | T13043 | arg1Of | humans,[ |
R8684 | T13044 | T13043 | arg2Of | "61,62",[ |
R8685 | T13045 | T13043 | arg3Of | ],[ |
R8686 | T13048 | T13046 | arg1Of | degree,A |
R8687 | T13048 | T13047 | arg1Of | degree,high |
R8688 | T13048 | T13049 | arg1Of | degree,of |
R8689 | T13048 | T13051 | arg1Of | degree,between |
R8690 | T13048 | T13059 | arg1Of | degree,might |
R8691 | T13048 | T13060 | arg1Of | degree,be |
R8692 | T13048 | T13061 | arg2Of | degree,expected |
R8693 | T13050 | T13049 | arg2Of | overlap,of |
R8694 | T13054 | T13052 | arg1Of | erythematosus,systemic |
R8695 | T13054 | T13053 | arg1Of | erythematosus,lupus |
R8696 | T13054 | T13055 | arg1Of | erythematosus,and |
R8697 | T13055 | T13051 | arg2Of | and,between |
R8698 | T13058 | T13055 | arg2Of | loci,and |
R8699 | T13058 | T13056 | arg1Of | loci,RA |
R8700 | T13058 | T13057 | arg1Of | loci,susceptibility |
R8701 | T13061 | T13059 | arg2Of | expected,might |
R8702 | T13061 | T13060 | arg2Of | expected,be |
R8703 | T13061 | T13062 | arg1Of | expected,as |
R8704 | T13065 | T13063 | arg1Of | diseases,the |
R8705 | T13065 | T13064 | arg1Of | diseases,two |
R8706 | T13065 | T13066 | arg1Of | diseases,show |
R8707 | T13066 | T13062 | arg2Of | show,as |
R8708 | T13066 | T13070 | arg1Of | show,in |
R8709 | T13069 | T13066 | arg2Of | overlap,show |
R8710 | T13069 | T13067 | arg1Of | overlap,some |
R8711 | T13069 | T13068 | arg1Of | overlap,clinical |
R8712 | T13072 | T13071 | arg1Of | involvement,joint |
R8713 | T13072 | T13073 | arg1Of | involvement,"," |
R8714 | T13073 | T13076 | arg1Of | ",","," |
R8715 | T13075 | T13073 | arg2Of | production,"," |
R8716 | T13075 | T13074 | arg1Of | production,autoantibody |
R8717 | T13076 | T13079 | arg1Of | ",",and |
R8718 | T13078 | T13076 | arg2Of | features,"," |
R8719 | T13078 | T13077 | arg1Of | features,systemic |
R8720 | T13079 | T13070 | arg2Of | and,in |
R8721 | T13080 | T13079 | arg2Of | response,and |
R8722 | T13080 | T13081 | arg1Of | response,to |
R8723 | T13082 | T13081 | arg2Of | treatments,to |
R8724 | T13082 | T13084 | arg1Of | treatments,as |
R8725 | T13084 | T13083 | arg1Of | as,such |
R8726 | T13086 | T13084 | arg2Of | depletion,as |
R8727 | T13086 | T13085 | arg1Of | depletion,B-cell |
R8728 | T13086 | T13087 | arg1Of | depletion,( |
R8729 | T13088 | T13087 | arg2Of | rituximab,( |
R8730 | T13089 | T13087 | arg3Of | ),( |
R8731 | T13093 | T13091 | arg2Of | be,will |
R8732 | T13093 | T13092 | arg1Of | be,therefore |
R8733 | T13094 | T13093 | arg2Of | interesting,be |
R8734 | T13096 | T13090 | arg1Of | investigate,It |
R8735 | T13096 | T13091 | arg1Of | investigate,will |
R8736 | T13096 | T13093 | arg1Of | investigate,be |
R8737 | T13096 | T13094 | arg1Of | investigate,interesting |
R8738 | T13096 | T13095 | arg1Of | investigate,to |
R8739 | T13098 | T13099 | arg1Of | SNPs,that |
R8740 | T13098 | T13100 | arg1Of | SNPs,have |
R8741 | T13098 | T13101 | arg1Of | SNPs,been |
R8742 | T13098 | T13102 | arg2Of | SNPs,reported |
R8743 | T13098 | T13104 | arg1Of | SNPs,be |
R8744 | T13098 | T13105 | arg2Of | SNPs,associated |
R8745 | T13098 | T13110 | arg1Of | SNPs,are |
R8746 | T13098 | T13112 | arg2Of | SNPs,associated |
R8747 | T13102 | T13100 | arg2Of | reported,have |
R8748 | T13102 | T13101 | arg2Of | reported,been |
R8749 | T13105 | T13102 | arg3Of | associated,reported |
R8750 | T13105 | T13103 | arg1Of | associated,to |
R8751 | T13105 | T13104 | arg2Of | associated,be |
R8752 | T13105 | T13106 | arg1Of | associated,with |
R8753 | T13109 | T13106 | arg2Of | erythematosus,with |
R8754 | T13109 | T13107 | arg1Of | erythematosus,systemic |
R8755 | T13109 | T13108 | arg1Of | erythematosus,lupus |
R8756 | T13112 | T13096 | arg2Of | associated,investigate |
R8757 | T13112 | T13097 | arg1Of | associated,whether |
R8758 | T13112 | T13110 | arg2Of | associated,are |
R8759 | T13112 | T13111 | arg1Of | associated,also |
R8760 | T13112 | T13113 | arg1Of | associated,with |
R8761 | T13114 | T13113 | arg2Of | RA,with |
R9347 | T14245 | T14244 | arg1Of | protein,Cylindromatosis |
R9348 | T14246 | T14247 | arg1Of | Cylindromatosis,( |
R9349 | T14248 | T14247 | arg2Of | CYLD,( |
R9350 | T14249 | T14247 | arg3Of | ),( |
R9351 | T14250 | T14246 | arg1Of | protein,Cylindromatosis |
R9352 | T14250 | T14251 | arg1Of | protein,was |
R9353 | T14250 | T14253 | arg2Of | protein,identified |
R9354 | T14253 | T14251 | arg2Of | identified,was |
R9355 | T14253 | T14252 | arg1Of | identified,originally |
R9356 | T14253 | T14254 | arg1Of | identified,as |
R9357 | T14257 | T14254 | arg2Of | suppressor,as |
R9358 | T14257 | T14255 | arg1Of | suppressor,a |
R9359 | T14257 | T14256 | arg1Of | suppressor,tumour |
R9360 | T14257 | T14258 | arg2Of | suppressor,involved |
R9361 | T14258 | T14259 | arg1Of | involved,in |
R9362 | T14261 | T14259 | arg2Of | cylindromatosis,in |
R9363 | T14261 | T14260 | arg1Of | cylindromatosis,familial |
R9364 | T14261 | T14262 | arg1Of | cylindromatosis,[ |
R9365 | T14263 | T14262 | arg2Of | 63,[ |
R9366 | T14264 | T14262 | arg3Of | ],[ |
R9367 | T14265 | T14266 | arg1Of | CYLD,is |
R9368 | T14265 | T14268 | arg2Of | CYLD,involved |
R9369 | T14268 | T14266 | arg2Of | involved,is |
R9370 | T14268 | T14267 | arg1Of | involved,also |
R9371 | T14268 | T14269 | arg1Of | involved,"," |
R9372 | T14268 | T14270 | arg1Of | involved,however |
R9373 | T14268 | T14271 | arg1Of | involved,"," |
R9374 | T14268 | T14272 | arg1Of | involved,in |
R9375 | T14275 | T14272 | arg2Of | processes,in |
R9376 | T14275 | T14273 | arg1Of | processes,diverse |
R9377 | T14275 | T14274 | arg1Of | processes,physiological |
R9378 | T14275 | T14276 | arg1Of | processes,ranging |
R9379 | T14276 | T14277 | arg1Of | ranging,from |
R9380 | T14276 | T14281 | arg1Of | ranging,to |
R9381 | T14278 | T14279 | arg1Of | immunity,and |
R9382 | T14279 | T14277 | arg2Of | and,from |
R9383 | T14280 | T14279 | arg2Of | inflammation,and |
R9384 | T14284 | T14282 | arg1Of | progression,cell |
R9385 | T14284 | T14283 | arg1Of | progression,cycle |
R9386 | T14284 | T14285 | arg1Of | progression,"," |
R9387 | T14285 | T14288 | arg1Of | ",",and |
R9388 | T14286 | T14285 | arg2Of | spermatogenesis,"," |
R9389 | T14288 | T14281 | arg2Of | and,to |
R9390 | T14288 | T14287 | arg1Of | and,"," |
R9391 | T14289 | T14288 | arg2Of | osteoclastogenesis,and |
R9392 | T14289 | T14290 | arg1Of | osteoclastogenesis,( |
R9393 | T14291 | T14290 | arg2Of | reviewed,( |
R9394 | T14291 | T14292 | arg1Of | reviewed,in |
R9395 | T14291 | T14293 | arg1Of | reviewed,[ |
R9396 | T14294 | T14293 | arg2Of | 64,[ |
R9397 | T14295 | T14293 | arg3Of | ],[ |
R9398 | T14296 | T14290 | arg3Of | ),( |
R9399 | T14297 | T14298 | arg1Of | CYLD,is |
R9400 | T14298 | T14327 | arg1Of | is,"," |
R9401 | T14298 | T14328 | arg1Of | is,by |
R9402 | T14301 | T14298 | arg2Of | enzyme,is |
R9403 | T14301 | T14299 | arg1Of | enzyme,a |
R9404 | T14301 | T14300 | arg1Of | enzyme,deubiquitinating |
R9405 | T14301 | T14302 | arg1Of | enzyme,that |
R9406 | T14301 | T14304 | arg1Of | enzyme,regulates |
R9407 | T14304 | T14303 | arg1Of | regulates,negatively |
R9408 | T14306 | T14304 | arg2Of | signalling,regulates |
R9409 | T14306 | T14305 | arg1Of | signalling,NF-κB |
R9410 | T14306 | T14307 | arg2Of | signalling,initiated |
R9411 | T14306 | T14316 | arg1Of | signalling,( |
R9412 | T14306 | T14323 | arg1Of | signalling,( |
R9413 | T14309 | T14310 | arg1Of | TNFR,"," |
R9414 | T14310 | T14312 | arg1Of | ",",and |
R9415 | T14311 | T14310 | arg2Of | RANK,"," |
R9416 | T14312 | T14307 | arg1Of | and,initiated |
R9417 | T14312 | T14308 | arg2Of | and,by |
R9418 | T14315 | T14312 | arg2Of | stimulation,and |
R9419 | T14315 | T14313 | arg1Of | stimulation,T-cell |
R9420 | T14315 | T14314 | arg1Of | stimulation,receptor |
R9421 | T14317 | T14316 | arg2Of | reviewed,( |
R9422 | T14317 | T14318 | arg1Of | reviewed,in |
R9423 | T14317 | T14319 | arg1Of | reviewed,[ |
R9424 | T14320 | T14319 | arg2Of | 64,[ |
R9425 | T14321 | T14319 | arg3Of | ],[ |
R9426 | T14322 | T14316 | arg3Of | ),( |
R9427 | T14324 | T14323 | arg2Of | Figure,( |
R9428 | T14324 | T14325 | arg1Of | Figure,1 |
R9429 | T14326 | T14323 | arg3Of | ),( |
R9430 | T14333 | T14328 | arg2Of | proteins,by |
R9431 | T14333 | T14329 | arg1Of | proteins,deubiquitina-ting |
R9432 | T14333 | T14330 | arg1Of | proteins,several |
R9433 | T14333 | T14331 | arg1Of | proteins,NF-κB |
R9434 | T14333 | T14332 | arg1Of | proteins,signalling |
R9435 | T14333 | T14334 | arg1Of | proteins,including |
R9436 | T14335 | T14336 | arg1Of | NEMO,"," |
R9437 | T14336 | T14338 | arg1Of | ",","," |
R9438 | T14337 | T14336 | arg2Of | TRAF2,"," |
R9439 | T14338 | T14340 | arg1Of | ",","," |
R9440 | T14339 | T14338 | arg2Of | TRAF6,"," |
R9441 | T14340 | T14342 | arg1Of | ",","," |
R9442 | T14341 | T14340 | arg2Of | TRAF7,"," |
R9443 | T14342 | T14344 | arg1Of | ",",and |
R9444 | T14343 | T14342 | arg2Of | RIP1,"," |
R9445 | T14344 | T14334 | arg2Of | and,including |
R9446 | T14345 | T14344 | arg2Of | TAK1,and |
R9447 | T14346 | T14347 | arg1Of | Many,of |
R9448 | T14346 | T14349 | arg1Of | Many,are |
R9449 | T14346 | T14351 | arg2Of | Many,targeted |
R9450 | T14348 | T14347 | arg2Of | these,of |
R9451 | T14351 | T14349 | arg2Of | targeted,are |
R9452 | T14351 | T14350 | arg1Of | targeted,also |
R9453 | T14351 | T14354 | arg1Of | targeted,and |
R9454 | T14353 | T14351 | arg1Of | A20,targeted |
R9455 | T14353 | T14352 | arg2Of | A20,by |
R9456 | T14356 | T14354 | arg2Of | is,and |
R9457 | T14356 | T14357 | arg1Of | is,still |
R9458 | T14356 | T14358 | arg1Of | is,not |
R9459 | T14359 | T14356 | arg2Of | clear,is |
R9460 | T14360 | T14355 | arg1Of | why,it |
R9461 | T14360 | T14356 | arg1Of | why,is |
R9462 | T14360 | T14359 | arg1Of | why,clear |
R9463 | T14362 | T14361 | arg1Of | cell,the |
R9464 | T14362 | T14363 | arg1Of | cell,needs |
R9465 | T14363 | T14360 | arg1Of | needs,why |
R9466 | T14363 | T14369 | modOf | needs,to |
R9467 | T14364 | T14367 | arg1Of | A20,as |
R9468 | T14367 | T14363 | arg2Of | as,needs |
R9469 | T14367 | T14365 | arg1Of | as,as |
R9470 | T14367 | T14366 | arg1Of | as,well |
R9471 | T14368 | T14367 | arg2Of | CYLD,as |
R9472 | T14370 | T14369 | arg1Of | control,to |
R9473 | T14372 | T14370 | arg2Of | activation,control |
R9474 | T14372 | T14371 | arg1Of | activation,NF-κB |
R9475 | T14374 | T14375 | arg1Of | A20,is |
R9476 | T14374 | T14377 | arg2Of | A20,expressed |
R9477 | T14377 | T14373 | arg2Of | expressed,As |
R9478 | T14377 | T14375 | arg2Of | expressed,is |
R9479 | T14377 | T14376 | arg1Of | expressed,only |
R9480 | T14377 | T14378 | arg1Of | expressed,in |
R9481 | T14377 | T14382 | arg1Of | expressed,upon |
R9482 | T14381 | T14378 | arg2Of | types,in |
R9483 | T14381 | T14379 | arg1Of | types,many |
R9484 | T14381 | T14380 | arg1Of | types,cell |
R9485 | T14383 | T14382 | arg2Of | stimulation,upon |
R9486 | T14385 | T14386 | arg1Of | it,has |
R9487 | T14385 | T14387 | arg1Of | it,been |
R9488 | T14385 | T14388 | arg2Of | it,suggested |
R9489 | T14388 | T14373 | arg1Of | suggested,As |
R9490 | T14388 | T14384 | arg1Of | suggested,"," |
R9491 | T14388 | T14386 | arg2Of | suggested,has |
R9492 | T14388 | T14387 | arg2Of | suggested,been |
R9493 | T14391 | T14390 | arg1Of | protein,this |
R9494 | T14391 | T14393 | arg1Of | protein,regulates |
R9495 | T14393 | T14392 | arg1Of | regulates,mainly |
R9496 | T14393 | T14400 | arg1Of | regulates,whereas |
R9497 | T14395 | T14393 | arg2Of | phases,regulates |
R9498 | T14395 | T14394 | arg1Of | phases,later |
R9499 | T14395 | T14396 | arg1Of | phases,of |
R9500 | T14398 | T14396 | arg2Of | signalling,of |
R9501 | T14398 | T14397 | arg1Of | signalling,NF-κB |
R9502 | T14400 | T14388 | arg3Of | whereas,suggested |
R9503 | T14400 | T14389 | arg1Of | whereas,that |
R9504 | T14400 | T14399 | arg1Of | whereas,"," |
R9505 | T14401 | T14402 | arg1Of | CYLD,would |
R9506 | T14401 | T14403 | arg1Of | CYLD,regulate |
R9507 | T14403 | T14400 | arg2Of | regulate,whereas |
R9508 | T14403 | T14402 | arg2Of | regulate,would |
R9509 | T14404 | T14405 | arg1Of | constitutive,and |
R9510 | T14406 | T14405 | arg2Of | early,and |
R9511 | T14407 | T14403 | arg2Of | signalling,regulate |
R9512 | T14407 | T14404 | arg1Of | signalling,constitutive |
R9513 | T14407 | T14406 | arg1Of | signalling,early |
R9514 | T14409 | T14408 | arg2Of | addition,In |
R9515 | T14413 | T14411 | arg1Of | activity,their |
R9516 | T14413 | T14412 | arg1Of | activity,relative |
R9517 | T14413 | T14414 | arg1Of | activity,might |
R9518 | T14413 | T14416 | arg1Of | activity,be |
R9519 | T14413 | T14418 | arg1Of | activity,dependent |
R9520 | T14416 | T14408 | arg1Of | be,In |
R9521 | T14416 | T14410 | arg1Of | be,"," |
R9522 | T14416 | T14414 | arg2Of | be,might |
R9523 | T14416 | T14415 | arg1Of | be,also |
R9524 | T14416 | T14419 | arg1Of | be,[ |
R9525 | T14418 | T14416 | arg2Of | dependent,be |
R9526 | T14418 | T14417 | arg1Of | dependent,cell-type |
R9527 | T14420 | T14419 | arg2Of | 64,[ |
R9528 | T14421 | T14419 | arg3Of | ],[ |
R9529 | T14424 | T14425 | arg1Of | CYLD,has |
R9530 | T14424 | T14426 | arg1Of | CYLD,been |
R9531 | T14424 | T14427 | arg2Of | CYLD,shown |
R9532 | T14424 | T14430 | arg1Of | CYLD,regulate |
R9533 | T14427 | T14422 | arg1Of | shown,Interestingly |
R9534 | T14427 | T14423 | arg1Of | shown,"," |
R9535 | T14427 | T14425 | arg2Of | shown,has |
R9536 | T14427 | T14426 | arg2Of | shown,been |
R9537 | T14430 | T14427 | arg3Of | regulate,shown |
R9538 | T14430 | T14428 | arg1Of | regulate,to |
R9539 | T14430 | T14429 | arg1Of | regulate,negatively |
R9540 | T14432 | T14431 | arg1Of | signalling,RANK |
R9541 | T14432 | T14433 | arg1Of | signalling,and |
R9542 | T14433 | T14430 | arg2Of | and,regulate |
R9543 | T14433 | T14435 | arg1Of | and,in |
R9544 | T14434 | T14433 | arg2Of | osteoclastogenesis,and |
R9545 | T14436 | T14435 | arg2Of | mice,in |
R9546 | T14436 | T14437 | arg1Of | mice,[ |
R9547 | T14438 | T14437 | arg2Of | 65,[ |
R9548 | T14439 | T14437 | arg3Of | ],[ |
R9549 | T14440 | T14441 | arg1Of | Mice,with |
R9550 | T14440 | T14447 | arg1Of | Mice,have |
R9551 | T14440 | T14452 | arg1Of | Mice,develop |
R9552 | T14444 | T14441 | arg2Of | deficiency,with |
R9553 | T14444 | T14442 | arg1Of | deficiency,a |
R9554 | T14444 | T14443 | arg1Of | deficiency,genetic |
R9555 | T14444 | T14445 | arg1Of | deficiency,of |
R9556 | T14446 | T14445 | arg2Of | CYLD,of |
R9557 | T14447 | T14451 | arg1Of | have,and |
R9558 | T14450 | T14447 | arg2Of | differentiation,have |
R9559 | T14450 | T14448 | arg1Of | differentiation,aberrant |
R9560 | T14450 | T14449 | arg1Of | differentiation,osteoclast |
R9561 | T14452 | T14451 | arg2Of | develop,and |
R9562 | T14454 | T14452 | arg2Of | osteoporosis,develop |
R9563 | T14454 | T14453 | arg1Of | osteoporosis,severe |
R9564 | T14456 | T14455 | arg1Of | precursors,Osteoclast |
R9565 | T14456 | T14457 | arg1Of | precursors,of |
R9566 | T14456 | T14460 | arg1Of | precursors,are |
R9567 | T14456 | T14461 | arg1Of | precursors,hyper-responsive |
R9568 | T14456 | T14466 | arg1Of | precursors,produce |
R9569 | T14459 | T14457 | arg2Of | mice,of |
R9570 | T14459 | T14458 | arg1Of | mice,these |
R9571 | T14460 | T14465 | arg1Of | are,and |
R9572 | T14461 | T14460 | arg2Of | hyper-responsive,are |
R9573 | T14461 | T14462 | arg1Of | hyper-responsive,to |
R9574 | T14464 | T14462 | arg2Of | differentiation,to |
R9575 | T14464 | T14463 | arg1Of | differentiation,RANKL-induced |
R9576 | T14466 | T14465 | arg2Of | produce,and |
R9577 | T14467 | T14468 | arg1Of | more,and |
R9578 | T14469 | T14468 | arg2Of | larger,and |
R9579 | T14470 | T14466 | arg2Of | osteoclasts,produce |
R9580 | T14470 | T14467 | arg1Of | osteoclasts,more |
R9581 | T14470 | T14469 | arg1Of | osteoclasts,larger |
R9582 | T14472 | T14471 | arg1Of | expression,CYLD |
R9583 | T14472 | T14473 | arg1Of | expression,is |
R9584 | T14472 | T14475 | arg2Of | expression,upregulated |
R9585 | T14472 | T14482 | arg1Of | expression,is |
R9586 | T14472 | T14483 | arg2Of | expression,recruited |
R9587 | T14475 | T14473 | arg2Of | upregulated,is |
R9588 | T14475 | T14474 | arg1Of | upregulated,markedly |
R9589 | T14475 | T14476 | arg1Of | upregulated,under |
R9590 | T14475 | T14481 | arg1Of | upregulated,and |
R9591 | T14477 | T14476 | arg2Of | conditions,under |
R9592 | T14477 | T14478 | arg1Of | conditions,of |
R9593 | T14480 | T14478 | arg2Of | osteoclastogenesis,of |
R9594 | T14480 | T14479 | arg1Of | osteoclastogenesis,RANKL-induced |
R9595 | T14481 | T14503 | arg1Of | and,"," |
R9596 | T14481 | T14504 | modOf | and,followed |
R9597 | T14483 | T14481 | arg2Of | recruited,and |
R9598 | T14483 | T14482 | arg2Of | recruited,is |
R9599 | T14483 | T14484 | arg1Of | recruited,to |
R9600 | T14483 | T14487 | arg1Of | recruited,via |
R9601 | T14483 | T14500 | arg1Of | recruited,[ |
R9602 | T14486 | T14484 | arg2Of | TRAF6,to |
R9603 | T14486 | T14485 | arg2Of | TRAF6,ubiquitinated |
R9604 | T14492 | T14487 | arg2Of | p62,via |
R9605 | T14492 | T14488 | arg1Of | p62,the |
R9606 | T14492 | T14489 | arg1Of | p62,ubiquitin-binding |
R9607 | T14492 | T14490 | arg1Of | p62,adaptor |
R9608 | T14492 | T14491 | arg1Of | p62,protein |
R9609 | T14492 | T14493 | arg1Of | p62,( |
R9610 | T14495 | T14493 | arg2Of | known,( |
R9611 | T14495 | T14494 | arg1Of | known,also |
R9612 | T14495 | T14496 | arg1Of | known,as |
R9613 | T14497 | T14496 | arg2Of | sequestosome,as |
R9614 | T14497 | T14498 | arg1Of | sequestosome,1 |
R9615 | T14499 | T14493 | arg3Of | ),( |
R9616 | T14501 | T14500 | arg2Of | 65,[ |
R9617 | T14502 | T14500 | arg3Of | ],[ |
R9618 | T14508 | T14504 | arg1Of | deubiquitination,followed |
R9619 | T14508 | T14505 | arg2Of | deubiquitination,by |
R9620 | T14508 | T14506 | arg1Of | deubiquitination,the |
R9621 | T14508 | T14507 | arg1Of | deubiquitination,CYLD-mediated |
R9622 | T14508 | T14509 | arg1Of | deubiquitination,of |
R9623 | T14510 | T14509 | arg2Of | TRAF6,of |
R9624 | T14513 | T14511 | arg2Of | context,In |
R9625 | T14513 | T14512 | arg1Of | context,this |
R9629 | T14516 | T14514 | arg1Of | is,"," |
R9630 | T14517 | T14516 | arg2Of | worth,is |
R9631 | T14518 | T14517 | arg2Of | mentioning,worth |
R9632 | T14521 | T14520 | arg1Of | mice,transgenic |
R9633 | T14521 | T14522 | arg1Of | mice,expressing |
R9634 | T14521 | T14529 | arg1Of | mice,display |
R9635 | T14521 | T14533 | arg1Of | mice,develop |
R9636 | T14525 | T14522 | arg2Of | form,expressing |
R9637 | T14525 | T14523 | arg1Of | form,a |
R9638 | T14525 | T14524 | arg2Of | form,mutated |
R9639 | T14525 | T14526 | arg1Of | form,of |
R9640 | T14527 | T14526 | arg2Of | p62,of |
R9641 | T14529 | T14532 | arg1Of | display,and |
R9642 | T14531 | T14529 | arg2Of | osteoclastogenesis,display |
R9643 | T14531 | T14530 | arg1Of | osteoclastogenesis,abnormal |
R9644 | T14532 | T14518 | arg2Of | and,mentioning |
R9645 | T14532 | T14519 | arg1Of | and,that |
R9646 | T14532 | T14528 | arg1Of | and,also |
R9647 | T14533 | T14532 | arg2Of | develop,and |
R9648 | T14533 | T14537 | arg1Of | develop,[ |
R9649 | T14536 | T14533 | arg2Of | loss,develop |
R9650 | T14536 | T14534 | arg1Of | loss,progressive |
R9651 | T14536 | T14535 | arg1Of | loss,bone |
R9652 | T14538 | T14537 | arg2Of | 66,[ |
R9653 | T14539 | T14537 | arg3Of | ],[ |
R9654 | T14541 | T14540 | arg1Of | findings,These |
R9655 | T14541 | T14542 | arg1Of | findings,suggest |
R9656 | T14545 | T14544 | arg1Of | inhibi-tion,CYLD-mediated |
R9657 | T14545 | T14546 | arg1Of | inhibi-tion,of |
R9658 | T14545 | T14550 | arg1Of | inhibi-tion,plays |
R9659 | T14545 | T14561 | arg1Of | inhibi-tion,indicate |
R9660 | T14549 | T14546 | arg2Of | signalling,of |
R9661 | T14549 | T14547 | arg1Of | signalling,RANK-induced |
R9662 | T14549 | T14548 | arg1Of | signalling,NF-κB |
R9663 | T14550 | T14554 | arg1Of | plays,in |
R9664 | T14550 | T14560 | arg1Of | plays,and |
R9665 | T14553 | T14550 | arg2Of | role,plays |
R9666 | T14553 | T14551 | arg1Of | role,a |
R9667 | T14553 | T14552 | arg1Of | role,key |
R9668 | T14557 | T14554 | arg2Of | regulation,in |
R9669 | T14557 | T14555 | arg1Of | regulation,the |
R9670 | T14557 | T14556 | arg1Of | regulation,negative |
R9671 | T14557 | T14558 | arg1Of | regulation,of |
R9672 | T14559 | T14558 | arg2Of | osteoclastogenesis,of |
R9673 | T14560 | T14542 | arg2Of | and,suggest |
R9674 | T14560 | T14543 | arg1Of | and,that |
R9675 | T14561 | T14560 | arg2Of | indicate,and |
R9676 | T14561 | T14563 | arg1Of | indicate,as |
R9677 | T14562 | T14561 | arg2Of | CYLD,indicate |
R9678 | T14567 | T14563 | arg2Of | factor,as |
R9679 | T14567 | T14564 | arg1Of | factor,a |
R9680 | T14567 | T14565 | arg1Of | factor,potential |
R9681 | T14567 | T14566 | arg1Of | factor,genetic |
R9682 | T14567 | T14568 | arg2Of | factor,involved |
R9683 | T14568 | T14569 | arg1Of | involved,in |
R9684 | T14571 | T14569 | arg2Of | pathology,in |
R9685 | T14571 | T14570 | arg1Of | pathology,the |
R9686 | T14571 | T14572 | arg1Of | pathology,of |
R9687 | T14574 | T14572 | arg2Of | disorders,of |
R9688 | T14574 | T14573 | arg1Of | disorders,bone |
R9689 | T14574 | T14576 | arg1Of | disorders,as |
R9690 | T14576 | T14575 | arg1Of | as,such |
R9691 | T14577 | T14576 | arg2Of | RA,as |
R10202 | T15550 | T15547 | arg1Of | protein,Single-immunoglobulin |
R10203 | T15550 | T15548 | arg1Of | protein,IL-1 |
R10204 | T15550 | T15549 | arg1Of | protein,receptor-related |
R10205 | T15555 | T15554 | arg2Of | SIGIRR,( |
R10206 | T15556 | T15554 | arg3Of | ),( |
R10207 | T15557 | T15551 | arg1Of | protein,Single-immunoglobulin |
R10208 | T15557 | T15552 | arg1Of | protein,IL-1 |
R10209 | T15557 | T15553 | arg1Of | protein,receptor-related |
R10210 | T15557 | T15554 | arg1Of | protein,( |
R10211 | T15557 | T15558 | arg1Of | protein,"," |
R10212 | T15557 | T15559 | arg1Of | protein,also |
R10213 | T15557 | T15560 | arg2Of | protein,known |
R10214 | T15557 | T15564 | arg1Of | protein,is |
R10215 | T15560 | T15561 | arg1Of | known,as |
R10216 | T15562 | T15561 | arg2Of | TIR-8,as |
R10217 | T15564 | T15563 | arg1Of | is,"," |
R10218 | T15566 | T15564 | arg2Of | member,is |
R10219 | T15566 | T15565 | arg1Of | member,a |
R10220 | T15566 | T15567 | arg1Of | member,of |
R10221 | T15570 | T15567 | arg2Of | family,of |
R10222 | T15570 | T15568 | arg1Of | family,the |
R10223 | T15570 | T15569 | arg1Of | family,TLR/IL-1R |
R10224 | T15570 | T15571 | arg1Of | family,that |
R10225 | T15570 | T15572 | arg1Of | family,has |
R10226 | T15570 | T15573 | arg1Of | family,been |
R10227 | T15570 | T15575 | arg2Of | family,characterised |
R10228 | T15575 | T15572 | arg2Of | characterised,has |
R10229 | T15575 | T15573 | arg2Of | characterised,been |
R10230 | T15575 | T15574 | arg1Of | characterised,extensively |
R10231 | T15575 | T15576 | arg1Of | characterised,as |
R10232 | T15575 | T15584 | arg1Of | characterised,"," |
R10233 | T15575 | T15586 | arg1Of | characterised,through |
R10234 | T15575 | T15598 | arg1Of | characterised,[ |
R10235 | T15575 | T15601 | arg1Of | characterised,( |
R10236 | T15578 | T15576 | arg2Of | inhibitor,as |
R10237 | T15578 | T15577 | arg1Of | inhibitor,an |
R10238 | T15578 | T15579 | arg1Of | inhibitor,of |
R10239 | T15580 | T15581 | arg1Of | IL-1R,and |
R10240 | T15582 | T15581 | arg2Of | TLR,and |
R10241 | T15583 | T15579 | arg2Of | signalling,of |
R10242 | T15583 | T15580 | arg1Of | signalling,IL-1R |
R10243 | T15583 | T15582 | arg1Of | signalling,TLR |
R10244 | T15586 | T15585 | arg1Of | through,probably |
R10245 | T15588 | T15587 | arg1Of | interaction,direct |
R10246 | T15588 | T15589 | arg1Of | interaction,with |
R10247 | T15588 | T15594 | arg1Of | interaction,"," |
R10248 | T15591 | T15589 | arg2Of | receptors,with |
R10249 | T15591 | T15590 | arg1Of | receptors,these |
R10250 | T15591 | T15592 | arg1Of | receptors,"," |
R10251 | T15593 | T15592 | arg2Of | MyD88,"," |
R10252 | T15594 | T15596 | arg1Of | ",",or |
R10253 | T15595 | T15594 | arg2Of | IRAK1,"," |
R10254 | T15596 | T15586 | arg2Of | or,through |
R10255 | T15597 | T15596 | arg2Of | TRAF6,or |
R10256 | T15599 | T15598 | arg2Of | 67,[ |
R10257 | T15600 | T15598 | arg3Of | ],[ |
R10258 | T15602 | T15601 | arg2Of | Figure,( |
R10259 | T15602 | T15603 | arg1Of | Figure,1 |
R10260 | T15604 | T15601 | arg3Of | ),( |
R10261 | T15608 | T15605 | arg2Of | role,Given |
R10262 | T15608 | T15606 | arg1Of | role,the |
R10263 | T15608 | T15607 | arg1Of | role,important |
R10264 | T15608 | T15609 | arg1Of | role,of |
R10265 | T15608 | T15614 | arg1Of | role,in |
R10266 | T15610 | T15611 | arg1Of | IL-1R,and |
R10267 | T15612 | T15611 | arg2Of | TLR,and |
R10268 | T15613 | T15609 | arg2Of | signalling,of |
R10269 | T15613 | T15610 | arg1Of | signalling,IL-1R |
R10270 | T15613 | T15612 | arg1Of | signalling,TLR |
R10271 | T15617 | T15614 | arg2Of | inflammation,in |
R10272 | T15617 | T15615 | arg1Of | inflammation,the |
R10273 | T15617 | T15616 | arg1Of | inflammation,chronic |
R10274 | T15617 | T15618 | arg2Of | inflammation,observed |
R10275 | T15618 | T15619 | arg1Of | observed,in |
R10276 | T15620 | T15619 | arg2Of | RA,in |
R10277 | T15620 | T15621 | arg1Of | RA,[ |
R10278 | T15622 | T15621 | arg2Of | 68,[ |
R10279 | T15623 | T15621 | arg3Of | ],[ |
R10280 | T15627 | T15625 | arg1Of | role,a |
R10281 | T15627 | T15626 | arg1Of | role,regulatory |
R10282 | T15627 | T15628 | arg1Of | role,for |
R10283 | T15627 | T15630 | arg1Of | role,in |
R10284 | T15627 | T15632 | arg1Of | role,is |
R10285 | T15627 | T15634 | arg1Of | role,unlikely |
R10286 | T15629 | T15628 | arg2Of | SIGIRR,for |
R10287 | T15631 | T15630 | arg2Of | RA,in |
R10288 | T15632 | T15605 | arg1Of | is,Given |
R10289 | T15632 | T15624 | arg1Of | is,"," |
R10290 | T15632 | T15633 | arg1Of | is,not |
R10291 | T15634 | T15632 | arg2Of | unlikely,is |
R10292 | T15635 | T15636 | arg1Of | SIGIRR,has |
R10293 | T15635 | T15643 | arg1Of | SIGIRR,being |
R10294 | T15635 | T15644 | arg2Of | SIGIRR,expressed |
R10295 | T15636 | T15642 | arg1Of | has,"," |
R10296 | T15639 | T15638 | arg1Of | restricted,very |
R10297 | T15641 | T15636 | arg2Of | pattern,has |
R10298 | T15641 | T15637 | arg1Of | pattern,a |
R10299 | T15641 | T15639 | arg1Of | pattern,restricted |
R10300 | T15641 | T15640 | arg1Of | pattern,expression |
R10301 | T15644 | T15642 | arg2Of | expressed,"," |
R10302 | T15644 | T15643 | arg2Of | expressed,being |
R10303 | T15644 | T15645 | arg1Of | expressed,in |
R10304 | T15644 | T15657 | arg1Of | expressed,in |
R10305 | T15644 | T15660 | arg1Of | expressed,[ |
R10306 | T15645 | T15655 | arg1Of | in,but |
R10307 | T15647 | T15646 | arg1Of | cells,epithelial |
R10308 | T15647 | T15648 | arg1Of | cells,"," |
R10309 | T15648 | T15650 | arg1Of | ",",and |
R10310 | T15649 | T15648 | arg2Of | monocytes,"," |
R10311 | T15650 | T15645 | arg2Of | and,in |
R10312 | T15653 | T15650 | arg2Of | cells,and |
R10313 | T15653 | T15651 | arg1Of | cells,immature |
R10314 | T15653 | T15652 | arg1Of | cells,dendritic |
R10315 | T15655 | T15654 | arg1Of | but,"," |
R10316 | T15657 | T15655 | arg2Of | in,but |
R10317 | T15657 | T15656 | arg1Of | in,not |
R10318 | T15659 | T15657 | arg2Of | macro-phages,in |
R10319 | T15659 | T15658 | arg1Of | macro-phages,mature |
R10320 | T15661 | T15660 | arg2Of | "69,70",[ |
R10321 | T15662 | T15660 | arg3Of | ],[ |
R10322 | T15666 | T15665 | arg1Of | overexpression,SIGIRR |
R10323 | T15666 | T15667 | arg1Of | overexpression,was |
R10324 | T15666 | T15668 | arg2Of | overexpression,shown |
R10325 | T15666 | T15670 | arg1Of | overexpression,inhibit |
R10326 | T15668 | T15663 | arg1Of | shown,Recently |
R10327 | T15668 | T15664 | arg1Of | shown,"," |
R10328 | T15668 | T15667 | arg2Of | shown,was |
R10329 | T15670 | T15668 | arg3Of | inhibit,shown |
R10330 | T15670 | T15669 | arg1Of | inhibit,to |
R10331 | T15673 | T15670 | arg2Of | release,inhibit |
R10332 | T15673 | T15671 | arg1Of | release,the |
R10333 | T15673 | T15672 | arg1Of | release,spontaneous |
R10334 | T15673 | T15674 | arg1Of | release,of |
R10335 | T15673 | T15677 | arg1Of | release,by |
R10336 | T15676 | T15674 | arg2Of | cytokines,of |
R10337 | T15676 | T15675 | arg1Of | cytokines,inflammatory |
R10338 | T15681 | T15677 | arg2Of | cells,by |
R10339 | T15681 | T15678 | arg1Of | cells,human |
R10340 | T15681 | T15679 | arg1Of | cells,RA |
R10341 | T15681 | T15680 | arg1Of | cells,synovial |
R10342 | T15684 | T15682 | arg1Of | function,This |
R10343 | T15684 | T15683 | arg1Of | function,inhibitory |
R10344 | T15684 | T15685 | arg1Of | function,of |
R10345 | T15684 | T15687 | arg1Of | function,was |
R10346 | T15684 | T15689 | arg2Of | function,confirmed |
R10347 | T15686 | T15685 | arg2Of | SIGIRR,of |
R10348 | T15689 | T15687 | arg2Of | confirmed,was |
R10349 | T15689 | T15688 | arg1Of | confirmed,further |
R10350 | T15689 | T15691 | arg1Of | confirmed,vivo |
R10351 | T15689 | T15692 | arg1Of | confirmed,"," |
R10352 | T15689 | T15693 | arg1Of | confirmed,since |
R10353 | T15691 | T15690 | arg1Of | vivo,in |
R10354 | T15695 | T15694 | arg1Of | mice,SIGIRR-deficient |
R10355 | T15695 | T15696 | arg1Of | mice,developed |
R10356 | T15696 | T15693 | arg2Of | developed,since |
R10357 | T15696 | T15712 | arg1Of | developed,[ |
R10358 | T15699 | T15698 | arg1Of | severe,more |
R10359 | T15700 | T15697 | arg1Of | disease,a |
R10360 | T15700 | T15699 | arg1Of | disease,severe |
R10361 | T15700 | T15701 | arg1Of | disease,in |
R10362 | T15700 | T15707 | arg1Of | disease,as |
R10363 | T15703 | T15701 | arg2Of | arthritis,in |
R10364 | T15703 | T15702 | arg1Of | arthritis,zymosan-induced |
R10365 | T15707 | T15696 | arg2Of | as,developed |
R10366 | T15707 | T15704 | arg1Of | as,"," |
R10367 | T15707 | T15705 | arg1Of | as,as |
R10368 | T15707 | T15706 | arg1Of | as,well |
R10369 | T15711 | T15707 | arg2Of | models,as |
R10370 | T15711 | T15708 | arg1Of | models,collagen-induced |
R10371 | T15711 | T15709 | arg1Of | models,arthritis |
R10372 | T15711 | T15710 | arg1Of | models,mouse |
R10373 | T15713 | T15712 | arg2Of | 70,[ |
R10374 | T15714 | T15712 | arg3Of | ],[ |
R10375 | T15717 | T15716 | arg2Of | be,will |
R10376 | T15718 | T15717 | arg2Of | interesting,be |
R10377 | T15720 | T15719 | arg1Of | compare,to |
R10378 | T15720 | T15735 | arg1Of | compare,or |
R10379 | T15722 | T15720 | arg2Of | expression,compare |
R10380 | T15722 | T15721 | arg1Of | expression,the |
R10381 | T15722 | T15723 | arg1Of | expression,of |
R10382 | T15722 | T15725 | arg1Of | expression,in |
R10383 | T15724 | T15723 | arg2Of | SIGIRR,of |
R10384 | T15727 | T15725 | arg2Of | patients,in |
R10385 | T15727 | T15726 | arg1Of | patients,RA |
R10386 | T15727 | T15728 | arg1Of | patients,with |
R10387 | T15730 | T15728 | arg2Of | expression,with |
R10388 | T15730 | T15729 | arg1Of | expression,its |
R10389 | T15730 | T15731 | arg1Of | expression,in |
R10390 | T15733 | T15731 | arg2Of | patients,in |
R10391 | T15733 | T15732 | arg1Of | patients,control |
R10392 | T15735 | T15715 | arg1Of | or,It |
R10393 | T15735 | T15716 | arg1Of | or,will |
R10394 | T15735 | T15717 | arg1Of | or,be |
R10395 | T15735 | T15718 | arg1Of | or,interesting |
R10396 | T15735 | T15734 | arg1Of | or,"," |
R10397 | T15737 | T15735 | arg2Of | investigate,or |
R10398 | T15737 | T15736 | arg1Of | investigate,to |
R10399 | T15740 | T15739 | arg1Of | function,the |
R10400 | T15740 | T15741 | arg1Of | function,of |
R10401 | T15740 | T15743 | arg1Of | function,is |
R10402 | T15740 | T15744 | arg2Of | function,compromised |
R10403 | T15742 | T15741 | arg2Of | SIGIRR,of |
R10404 | T15744 | T15737 | arg2Of | compromised,investigate |
R10405 | T15744 | T15738 | arg1Of | compromised,whether |
R10406 | T15744 | T15743 | arg2Of | compromised,is |
R10407 | T15744 | T15745 | arg1Of | compromised,in |
R10408 | T15747 | T15745 | arg2Of | patients,in |
R10409 | T15747 | T15746 | arg1Of | patients,RA |
R10410 | T15748 | T15749 | arg1Of | Because,of |
R10411 | T15753 | T15748 | arg2Of | pattern,Because |
R10412 | T15753 | T15750 | arg1Of | pattern,its |
R10413 | T15753 | T15751 | arg1Of | pattern,restricted |
R10414 | T15753 | T15752 | arg1Of | pattern,expression |
R10415 | T15755 | T15756 | arg1Of | SIGIRR,may |
R10416 | T15755 | T15758 | arg1Of | SIGIRR,be |
R10417 | T15758 | T15748 | arg1Of | be,Because |
R10418 | T15758 | T15754 | arg1Of | be,"," |
R10419 | T15758 | T15756 | arg2Of | be,may |
R10420 | T15758 | T15757 | arg1Of | be,also |
R10421 | T15762 | T15758 | arg2Of | target,be |
R10422 | T15762 | T15759 | arg1Of | target,an |
R10423 | T15762 | T15760 | arg1Of | target,interesting |
R10424 | T15762 | T15761 | arg1Of | target,therapeutic |
R10425 | T15762 | T15763 | arg1Of | target,in |
R10426 | T15764 | T15763 | arg2Of | RA,in |
R10780 | T16432 | T16430 | arg1Of | factor,TNF |
R10781 | T16432 | T16431 | arg1Of | factor,receptor-associated |
R10782 | T16432 | T16433 | arg1Of | factor,1 |
R10783 | T16434 | T16435 | arg1Of | TRAF1,is |
R10784 | T16435 | T16444 | arg1Of | is,because |
R10785 | T16438 | T16435 | arg2Of | member,is |
R10786 | T16438 | T16436 | arg1Of | member,a |
R10787 | T16438 | T16437 | arg1Of | member,unique |
R10788 | T16438 | T16439 | arg1Of | member,of |
R10789 | T16443 | T16439 | arg2Of | family,of |
R10790 | T16443 | T16440 | arg1Of | family,the |
R10791 | T16443 | T16441 | arg1Of | family,TRAF |
R10792 | T16443 | T16442 | arg1Of | family,protein |
R10793 | T16445 | T16446 | arg1Of | it,lacks |
R10794 | T16445 | T16453 | arg1Of | it,lacks |
R10795 | T16446 | T16451 | arg1Of | lacks,and |
R10796 | T16450 | T16446 | arg2Of | domain,lacks |
R10797 | T16450 | T16447 | arg1Of | domain,a |
R10798 | T16450 | T16448 | arg1Of | domain,RING |
R10799 | T16450 | T16449 | arg1Of | domain,finger |
R10800 | T16451 | T16444 | arg2Of | and,because |
R10801 | T16453 | T16451 | arg2Of | lacks,and |
R10802 | T16453 | T16452 | arg1Of | lacks,therefore |
R10803 | T16456 | T16453 | arg2Of | activity,lacks |
R10804 | T16456 | T16454 | arg1Of | activity,ubiquitin |
R10805 | T16456 | T16455 | arg1Of | activity,ligase |
R10806 | T16458 | T16457 | arg1Of | data,Accumulating |
R10807 | T16458 | T16459 | arg1Of | data,support |
R10808 | T16459 | T16480 | arg1Of | support,"," |
R10809 | T16459 | T16482 | arg1Of | support,in |
R10810 | T16459 | T16486 | arg1Of | support,[ |
R10811 | T16461 | T16459 | arg2Of | role,support |
R10812 | T16461 | T16460 | arg1Of | role,a |
R10813 | T16461 | T16462 | arg1Of | role,for |
R10814 | T16461 | T16464 | arg1Of | role,as |
R10815 | T16461 | T16475 | arg1Of | role,by |
R10816 | T16463 | T16462 | arg2Of | TRAF1,for |
R10817 | T16467 | T16468 | arg1Of | negative,and |
R10818 | T16470 | T16468 | arg2Of | positive,and |
R10819 | T16470 | T16469 | arg1Of | positive,a |
R10820 | T16471 | T16464 | arg2Of | modulator,as |
R10821 | T16471 | T16465 | arg1Of | modulator,both |
R10822 | T16471 | T16466 | arg1Of | modulator,a |
R10823 | T16471 | T16467 | arg1Of | modulator,negative |
R10824 | T16471 | T16470 | arg1Of | modulator,positive |
R10825 | T16471 | T16472 | arg1Of | modulator,of |
R10826 | T16474 | T16472 | arg2Of | signalling,of |
R10827 | T16474 | T16473 | arg1Of | signalling,NF-κB |
R10828 | T16479 | T16475 | arg2Of | receptors,by |
R10829 | T16479 | T16476 | arg1Of | receptors,certain |
R10830 | T16479 | T16477 | arg1Of | receptors,TNF |
R10831 | T16479 | T16478 | arg1Of | receptors,family |
R10832 | T16482 | T16481 | arg1Of | in,possibly |
R10833 | T16485 | T16482 | arg2Of | manner,in |
R10834 | T16485 | T16483 | arg1Of | manner,a |
R10835 | T16485 | T16484 | arg1Of | manner,cell-type-dependent |
R10836 | T16487 | T16486 | arg2Of | "71,72",[ |
R10837 | T16488 | T16486 | arg3Of | ],[ |
R10838 | T16489 | T16490 | arg1Of | Expression,of |
R10839 | T16489 | T16492 | arg1Of | Expression,is |
R10840 | T16489 | T16493 | arg1Of | Expression,inducible |
R10841 | T16491 | T16490 | arg2Of | TRAF1,of |
R10842 | T16492 | T16496 | arg1Of | is,and |
R10843 | T16493 | T16492 | arg2Of | inducible,is |
R10844 | T16493 | T16494 | arg1Of | inducible,by |
R10845 | T16495 | T16494 | arg2Of | TNF,by |
R10846 | T16497 | T16498 | arg1Of | overexpression,of |
R10847 | T16497 | T16500 | arg1Of | overexpression,inhibits |
R10848 | T16499 | T16498 | arg2Of | TRAF1,of |
R10849 | T16500 | T16496 | arg2Of | inhibits,and |
R10850 | T16503 | T16500 | arg2Of | activation,inhibits |
R10851 | T16503 | T16501 | arg1Of | activation,TNF-induced |
R10852 | T16503 | T16502 | arg1Of | activation,NF-κB |
R10853 | T16506 | T16504 | arg1Of | cells,TRAF1-deficient |
R10854 | T16506 | T16505 | arg1Of | cells,T |
R10855 | T16506 | T16507 | arg1Of | cells,are |
R10856 | T16506 | T16508 | arg1Of | cells,hyper-responsive |
R10857 | T16507 | T16511 | arg1Of | are,"," |
R10858 | T16507 | T16512 | arg1Of | are,with |
R10859 | T16508 | T16507 | arg2Of | hyper-responsive,are |
R10860 | T16508 | T16509 | arg1Of | hyper-responsive,to |
R10861 | T16510 | T16509 | arg2Of | TNF,to |
R10862 | T16514 | T16515 | arg1Of | proliferation,and |
R10863 | T16515 | T16512 | arg2Of | and,with |
R10864 | T16515 | T16513 | arg2Of | and,enhanced |
R10865 | T16515 | T16517 | arg1Of | and,of |
R10866 | T16516 | T16515 | arg2Of | activation,and |
R10867 | T16521 | T16517 | arg2Of | pathway,of |
R10868 | T16521 | T16518 | arg1Of | pathway,the |
R10869 | T16521 | T16519 | arg1Of | pathway,NF-κB |
R10870 | T16521 | T16520 | arg1Of | pathway,signalling |
R10871 | T16522 | T16524 | arg1Of | TRAF1,functions |
R10872 | T16524 | T16523 | arg1Of | functions,also |
R10873 | T16524 | T16525 | arg1Of | functions,as |
R10874 | T16528 | T16525 | arg2Of | regulator,as |
R10875 | T16528 | T16526 | arg1Of | regulator,a |
R10876 | T16528 | T16527 | arg1Of | regulator,negative |
R10877 | T16528 | T16529 | arg1Of | regulator,of |
R10878 | T16532 | T16529 | arg2Of | activation,of |
R10879 | T16532 | T16530 | arg1Of | activation,CD40-induced |
R10880 | T16532 | T16531 | arg1Of | activation,NF-κB |
R10881 | T16535 | T16533 | arg1Of | cells,TRAF1-deficient |
R10882 | T16535 | T16534 | arg1Of | cells,dendritic |
R10883 | T16535 | T16539 | arg1Of | cells,show |
R10884 | T16539 | T16536 | arg1Of | show,"," |
R10885 | T16539 | T16537 | arg1Of | show,however |
R10886 | T16539 | T16538 | arg1Of | show,"," |
R10887 | T16539 | T16548 | arg1Of | show,"," |
R10888 | T16539 | T16549 | modOf | show,suggesting |
R10889 | T16541 | T16539 | arg2Of | responses,show |
R10890 | T16541 | T16540 | arg2Of | responses,attenuated |
R10891 | T16541 | T16542 | arg1Of | responses,to |
R10892 | T16544 | T16542 | arg2Of | stimulation,to |
R10893 | T16544 | T16543 | arg1Of | stimulation,secondary |
R10894 | T16544 | T16545 | arg1Of | stimulation,by |
R10895 | T16547 | T16545 | arg2Of | factors,by |
R10896 | T16547 | T16546 | arg1Of | factors,TRAF2-dependent |
R10897 | T16549 | T16554 | arg1Of | suggesting,in |
R10898 | T16553 | T16549 | arg2Of | role,suggesting |
R10899 | T16553 | T16550 | arg1Of | role,a |
R10900 | T16553 | T16551 | arg1Of | role,positive |
R10901 | T16553 | T16552 | arg1Of | role,regulatory |
R10902 | T16556 | T16554 | arg2Of | cells,in |
R10903 | T16556 | T16555 | arg1Of | cells,these |
R10904 | T16558 | T16557 | arg1Of | mechanism,The |
R10905 | T16558 | T16559 | arg2Of | mechanism,by |
R10906 | T16558 | T16560 | arg1Of | mechanism,which |
R10907 | T16558 | T16566 | arg1Of | mechanism,is |
R10908 | T16558 | T16568 | arg1Of | mechanism,unclear |
R10909 | T16561 | T16562 | arg1Of | TRAF1,modulates |
R10910 | T16562 | T16559 | arg1Of | modulates,by |
R10911 | T16565 | T16562 | arg2Of | activation,modulates |
R10912 | T16565 | T16563 | arg1Of | activation,NF- |
R10913 | T16565 | T16564 | arg1Of | activation,κB |
R10914 | T16566 | T16567 | arg1Of | is,still |
R10915 | T16568 | T16566 | arg2Of | unclear,is |
R10916 | T16570 | T16569 | arg1Of | probably,Most |
R10917 | T16572 | T16573 | arg1Of | TRAF1,competes |
R10918 | T16573 | T16570 | arg1Of | competes,probably |
R10919 | T16573 | T16571 | arg1Of | competes,"," |
R10920 | T16573 | T16574 | arg1Of | competes,with |
R10921 | T16577 | T16574 | arg2Of | members,with |
R10922 | T16577 | T16575 | arg1Of | members,TRAF |
R10923 | T16577 | T16576 | arg1Of | members,family |
R10924 | T16577 | T16578 | arg1Of | members,for |
R10925 | T16579 | T16578 | arg2Of | binding,for |
R10926 | T16579 | T16580 | arg1Of | binding,to |
R10927 | T16586 | T16580 | arg2Of | proteins,to |
R10928 | T16586 | T16581 | arg1Of | proteins,the |
R10929 | T16586 | T16582 | arg1Of | proteins,receptor |
R10930 | T16586 | T16583 | arg1Of | proteins,or |
R10931 | T16586 | T16584 | arg1Of | proteins,other |
R10932 | T16586 | T16585 | arg1Of | proteins,signalling |
R10933 | T16589 | T16590 | arg1Of | TRAF1,might |
R10934 | T16589 | T16591 | arg1Of | TRAF1,recruit |
R10935 | T16591 | T16587 | arg1Of | recruit,Alternatively |
R10936 | T16591 | T16588 | arg1Of | recruit,"," |
R10937 | T16591 | T16590 | arg2Of | recruit,might |
R10938 | T16592 | T16591 | arg2Of | A20,recruit |
R10939 | T16592 | T16593 | arg2Of | A20,with |
R10940 | T16592 | T16594 | arg1Of | A20,which |
R10941 | T16595 | T16596 | arg1Of | it,can |
R10942 | T16595 | T16598 | arg1Of | it,interact |
R10943 | T16598 | T16593 | arg1Of | interact,with |
R10944 | T16598 | T16596 | arg2Of | interact,can |
R10945 | T16598 | T16597 | arg1Of | interact,physically |
R10946 | T16598 | T16599 | arg1Of | interact,[ |
R10947 | T16600 | T16599 | arg2Of | 73,[ |
R10948 | T16601 | T16599 | arg3Of | ],[ |
R10949 | T16605 | T16602 | arg1Of | study,A |
R10950 | T16605 | T16603 | arg1Of | study,genome-wide |
R10951 | T16605 | T16604 | arg1Of | study,association |
R10952 | T16605 | T16606 | arg1Of | study,examining |
R10953 | T16605 | T16620 | arg1Of | study,identified |
R10954 | T16606 | T16611 | arg1Of | examining,among |
R10955 | T16607 | T16608 | arg1Of | more,than |
R10956 | T16609 | T16608 | arg2Of | "300,000",than |
R10957 | T16610 | T16606 | arg2Of | SNPs,examining |
R10958 | T16610 | T16607 | arg1Of | SNPs,more |
R10959 | T16613 | T16612 | arg1Of | "1,500",approximately |
R10960 | T16616 | T16613 | arg1Of | cases,"1,500" |
R10961 | T16616 | T16614 | arg1Of | cases,autoantibody-positive |
R10962 | T16616 | T16615 | arg1Of | cases,RA |
R10963 | T16616 | T16617 | arg1Of | cases,and |
R10964 | T16617 | T16611 | arg2Of | and,among |
R10965 | T16619 | T16617 | arg2Of | controls,and |
R10966 | T16619 | T16618 | arg1Of | controls,"1,800" |
R10967 | T16620 | T16630 | arg1Of | identified,as |
R10968 | T16620 | T16636 | arg1Of | identified,[ |
R10969 | T16623 | T16620 | arg2Of | variation,identified |
R10970 | T16623 | T16621 | arg1Of | variation,a |
R10971 | T16623 | T16622 | arg1Of | variation,genetic |
R10972 | T16623 | T16624 | arg1Of | variation,at |
R10973 | T16629 | T16624 | arg2Of | locus,at |
R10974 | T16629 | T16625 | arg1Of | locus,the |
R10975 | T16629 | T16626 | arg1Of | locus,TRAF1-complement |
R10976 | T16629 | T16627 | arg1Of | locus,component |
R10977 | T16629 | T16628 | arg1Of | locus,5 |
R10978 | T16635 | T16630 | arg2Of | locus,as |
R10979 | T16635 | T16631 | arg1Of | locus,an |
R10980 | T16635 | T16632 | arg1Of | locus,important |
R10981 | T16635 | T16633 | arg1Of | locus,RA |
R10982 | T16635 | T16634 | arg1Of | locus,risk |
R10983 | T16637 | T16636 | arg2Of | 74,[ |
R10984 | T16638 | T16636 | arg3Of | ],[ |
R10985 | T16640 | T16639 | arg1Of | work,Subsequent |
R10986 | T16640 | T16641 | arg1Of | work,indicates |
R10987 | T16643 | T16644 | arg1Of | TRAF1,is |
R10988 | T16643 | T16646 | arg1Of | TRAF1,likely |
R10989 | T16643 | T16648 | arg1Of | TRAF1,be |
R10990 | T16644 | T16641 | arg2Of | is,indicates |
R10991 | T16644 | T16642 | arg1Of | is,that |
R10992 | T16644 | T16652 | arg1Of | is,[ |
R10993 | T16646 | T16644 | arg2Of | likely,is |
R10994 | T16646 | T16645 | arg1Of | likely,more |
R10995 | T16648 | T16646 | arg2Of | be,likely |
R10996 | T16648 | T16647 | arg1Of | be,to |
R10997 | T16651 | T16648 | arg2Of | locus,be |
R10998 | T16651 | T16649 | arg1Of | locus,the |
R10999 | T16651 | T16650 | arg1Of | locus,causative |
R11000 | T16653 | T16652 | arg2Of | 75,[ |
R11001 | T16654 | T16652 | arg3Of | ],[ |
R11002 | T16656 | T16655 | arg1Of | work,Recent |
R11007 | T16660 | T16659 | arg1Of | population,Korean |
R11008 | T16662 | T16661 | arg1Of | demonstrates,also |
R11009 | T16664 | T16662 | arg2Of | association,demonstrates |
R11010 | T16664 | T16663 | arg1Of | association,genetic |
R11011 | T16664 | T16665 | arg1Of | association,of |
R11012 | T16668 | T16665 | arg2Of | region,of |
R11013 | T16668 | T16666 | arg1Of | region,the |
R11014 | T16668 | T16667 | arg1Of | region,TRAF1 |
R11015 | T16668 | T16669 | arg1Of | region,with |
R11016 | T16670 | T16669 | arg2Of | RA,with |
R11017 | T16670 | T16671 | arg1Of | RA,[ |
R11018 | T16672 | T16671 | arg2Of | 76,[ |
R11019 | T16673 | T16671 | arg3Of | ],[ |
R11440 | T17544 | T17545 | arg1Of | miRNAs,are |
R11441 | T17544 | T17553 | arg1Of | miRNAs,represent |
R11442 | T17545 | T17552 | arg1Of | are,and |
R11443 | T17547 | T17546 | arg1Of | discovered,recently |
R11444 | T17548 | T17545 | arg2Of | regulators,are |
R11445 | T17548 | T17547 | arg1Of | regulators,discovered |
R11446 | T17548 | T17549 | arg1Of | regulators,of |
R11447 | T17551 | T17549 | arg2Of | expression,of |
R11448 | T17551 | T17550 | arg1Of | expression,gene |
R11449 | T17553 | T17552 | arg2Of | represent,and |
R11450 | T17555 | T17553 | arg2Of | class,represent |
R11451 | T17555 | T17554 | arg1Of | class,a |
R11452 | T17555 | T17556 | arg1Of | class,of |
R11453 | T17559 | T17556 | arg2Of | molecules,of |
R11454 | T17559 | T17557 | arg1Of | molecules,noncoding |
R11455 | T17559 | T17558 | arg1Of | molecules,RNA |
R11456 | T17559 | T17560 | arg1Of | molecules,essential |
R11457 | T17560 | T17561 | arg1Of | essential,in |
R11458 | T17563 | T17564 | arg1Of | cellular,and |
R11459 | T17565 | T17564 | arg2Of | developmental,and |
R11460 | T17566 | T17561 | arg2Of | processes,in |
R11461 | T17566 | T17562 | arg1Of | processes,many |
R11462 | T17566 | T17563 | arg1Of | processes,cellular |
R11463 | T17566 | T17565 | arg1Of | processes,developmental |
R11464 | T17566 | T17567 | arg1Of | processes,"," |
R11465 | T17566 | T17568 | arg1Of | processes,including |
R11466 | T17570 | T17569 | arg1Of | responses,immune |
R11467 | T17570 | T17571 | arg1Of | responses,and |
R11468 | T17571 | T17568 | arg2Of | and,including |
R11469 | T17572 | T17571 | arg2Of | inflammation,and |
R11470 | T17573 | T17574 | arg1Of | They,bind |
R11471 | T17576 | T17574 | arg2Of | 3'-UTR,bind |
R11472 | T17576 | T17575 | arg1Of | 3'-UTR,the |
R11473 | T17576 | T17577 | arg1Of | 3'-UTR,of |
R11474 | T17579 | T17577 | arg2Of | mRNAs,of |
R11475 | T17579 | T17578 | arg1Of | mRNAs,target |
R11476 | T17579 | T17580 | arg1Of | mRNAs,leading |
R11477 | T17580 | T17581 | arg1Of | leading,to |
R11478 | T17583 | T17582 | arg1Of | repression,the |
R11479 | T17583 | T17584 | arg1Of | repression,of |
R11480 | T17583 | T17587 | arg1Of | repression,and |
R11481 | T17586 | T17584 | arg2Of | expression,of |
R11482 | T17586 | T17585 | arg1Of | expression,protein |
R11483 | T17587 | T17581 | arg2Of | and,to |
R11484 | T17589 | T17587 | arg2Of | promotion,and |
R11485 | T17589 | T17588 | arg1Of | promotion,the |
R11486 | T17589 | T17590 | arg1Of | promotion,of |
R11487 | T17593 | T17590 | arg2Of | degradation,of |
R11488 | T17593 | T17591 | arg1Of | degradation,target |
R11489 | T17593 | T17592 | arg1Of | degradation,mRNA |
R11490 | T17593 | T17594 | arg1Of | degradation,[ |
R11491 | T17595 | T17594 | arg2Of | 77,[ |
R11492 | T17596 | T17594 | arg3Of | ],[ |
R11493 | T17597 | T17598 | arg1Of | miR-146a/b,and |
R11494 | T17598 | T17600 | arg1Of | and,are |
R11495 | T17598 | T17601 | arg1Of | and,of |
R11496 | T17599 | T17598 | arg2Of | miR-155,and |
R11497 | T17600 | T17609 | arg1Of | are,"," |
R11498 | T17600 | T17610 | arg1Of | are,since |
R11499 | T17601 | T17600 | arg2Of | of,are |
R11500 | T17603 | T17601 | arg2Of | interest,of |
R11501 | T17603 | T17602 | arg1Of | interest,particular |
R11502 | T17603 | T17604 | arg1Of | interest,for |
R11503 | T17606 | T17604 | arg2Of | signalling,for |
R11504 | T17606 | T17605 | arg1Of | signalling,inflammatory |
R11505 | T17606 | T17607 | arg1Of | signalling,to |
R11506 | T17608 | T17607 | arg2Of | NF-κB,to |
R11507 | T17612 | T17611 | arg1Of | miRNAs,these |
R11508 | T17612 | T17613 | arg1Of | miRNAs,can |
R11509 | T17612 | T17614 | arg1Of | miRNAs,be |
R11510 | T17612 | T17615 | arg2Of | miRNAs,induced |
R11511 | T17615 | T17610 | arg2Of | induced,since |
R11512 | T17615 | T17613 | arg2Of | induced,can |
R11513 | T17615 | T17614 | arg2Of | induced,be |
R11514 | T17618 | T17615 | arg1Of | stimuli,induced |
R11515 | T17618 | T17616 | arg2Of | stimuli,by |
R11516 | T17618 | T17617 | arg1Of | stimuli,inflammatory |
R11517 | T17618 | T17620 | arg1Of | stimuli,as |
R11518 | T17620 | T17619 | arg1Of | as,such |
R11519 | T17621 | T17622 | arg1Of | IL-1β,"," |
R11520 | T17622 | T17624 | arg1Of | ",",and |
R11521 | T17623 | T17622 | arg2Of | TNF,"," |
R11522 | T17624 | T17620 | arg2Of | and,as |
R11523 | T17625 | T17624 | arg2Of | TLRs,and |
R11524 | T17625 | T17626 | arg1Of | TLRs,[ |
R11525 | T17627 | T17626 | arg2Of | "78,79",[ |
R11526 | T17628 | T17626 | arg3Of | ],[ |
R11527 | T17630 | T17629 | arg2Of | addition,In |
R11528 | T17632 | T17633 | arg1Of | miR-146a,is |
R11529 | T17633 | T17629 | arg1Of | is,In |
R11530 | T17633 | T17631 | arg1Of | is,"," |
R11531 | T17633 | T17638 | arg1Of | is,and |
R11532 | T17636 | T17633 | arg2Of | gene,is |
R11533 | T17636 | T17634 | arg1Of | gene,an |
R11534 | T17636 | T17635 | arg1Of | gene,NF-κB-dependent |
R11535 | T17638 | T17637 | arg1Of | and,"," |
R11536 | T17643 | T17644 | arg1Of | IRAK1,and |
R11537 | T17644 | T17639 | arg1Of | and,the |
R11538 | T17644 | T17640 | arg1Of | and,NF-κB |
R11539 | T17644 | T17641 | arg1Of | and,signalling |
R11540 | T17644 | T17642 | arg1Of | and,molecules |
R11541 | T17644 | T17646 | arg1Of | and,were |
R11542 | T17644 | T17647 | arg2Of | and,identified |
R11543 | T17645 | T17644 | arg2Of | TRAF6,and |
R11544 | T17647 | T17638 | arg2Of | identified,and |
R11545 | T17647 | T17646 | arg2Of | identified,were |
R11546 | T17647 | T17648 | arg1Of | identified,as |
R11547 | T17647 | T17653 | arg1Of | identified,[ |
R11548 | T17647 | T17656 | arg1Of | identified,( |
R11549 | T17650 | T17648 | arg2Of | genes,as |
R11550 | T17650 | T17649 | arg1Of | genes,target |
R11551 | T17650 | T17651 | arg1Of | genes,of |
R11552 | T17652 | T17651 | arg2Of | miR-146a,of |
R11553 | T17654 | T17653 | arg2Of | 78,[ |
R11554 | T17655 | T17653 | arg3Of | ],[ |
R11555 | T17657 | T17656 | arg2Of | Figure,( |
R11556 | T17657 | T17658 | arg1Of | Figure,1 |
R11557 | T17659 | T17656 | arg3Of | ),( |
R11558 | T17662 | T17663 | arg1Of | miR-155,was |
R11559 | T17662 | T17664 | arg2Of | miR-155,shown |
R11560 | T17664 | T17660 | arg1Of | shown,Similarly |
R11561 | T17664 | T17661 | arg1Of | shown,"," |
R11562 | T17664 | T17663 | arg2Of | shown,was |
R11563 | T17664 | T17665 | arg1Of | shown,to |
R11564 | T17664 | T17668 | arg1Of | shown,for |
R11565 | T17667 | T17665 | arg2Of | transcripts,to |
R11566 | T17667 | T17666 | arg1Of | transcripts,target |
R11567 | T17673 | T17669 | arg1Of | IKKε,the |
R11568 | T17673 | T17670 | arg1Of | IKKε,NF-κB |
R11569 | T17673 | T17671 | arg1Of | IKKε,signalling |
R11570 | T17673 | T17672 | arg1Of | IKKε,molecules |
R11571 | T17673 | T17674 | arg1Of | IKKε,and |
R11572 | T17674 | T17668 | arg2Of | and,for |
R11573 | T17675 | T17674 | arg2Of | RIP1,and |
R11574 | T17675 | T17676 | arg1Of | RIP1,[ |
R11575 | T17677 | T17676 | arg2Of | "79,80",[ |
R11576 | T17678 | T17676 | arg3Of | ],[ |
R11577 | T17682 | T17683 | arg1Of | miR-146,and |
R11578 | T17683 | T17681 | arg1Of | and,both |
R11579 | T17683 | T17685 | arg1Of | and,are |
R11580 | T17683 | T17686 | arg2Of | and,expressed |
R11581 | T17684 | T17683 | arg2Of | miR-155,and |
R11582 | T17686 | T17685 | arg2Of | expressed,are |
R11583 | T17686 | T17687 | arg1Of | expressed,at |
R11584 | T17686 | T17704 | arg1Of | expressed,in |
R11585 | T17686 | T17712 | arg1Of | expressed,[ |
R11586 | T17687 | T17703 | arg1Of | at,as |
R11587 | T17689 | T17687 | arg2Of | levels,at |
R11588 | T17689 | T17688 | arg1Of | levels,higher |
R11589 | T17689 | T17690 | arg1Of | levels,in |
R11590 | T17693 | T17691 | arg1Of | fibroblasts,RA |
R11591 | T17693 | T17692 | arg1Of | fibroblasts,synovial |
R11592 | T17693 | T17694 | arg1Of | fibroblasts,and |
R11593 | T17694 | T17690 | arg2Of | and,in |
R11594 | T17696 | T17694 | arg2Of | tissue,and |
R11595 | T17696 | T17695 | arg1Of | tissue,synovial |
R11596 | T17696 | T17697 | arg1Of | tissue,[ |
R11597 | T17698 | T17697 | arg2Of | "81,82",[ |
R11598 | T17699 | T17697 | arg3Of | ],[ |
R11599 | T17703 | T17700 | arg1Of | as,"," |
R11600 | T17703 | T17701 | arg1Of | as,as |
R11601 | T17703 | T17702 | arg1Of | as,well |
R11602 | T17704 | T17703 | arg2Of | in,as |
R11603 | T17708 | T17704 | arg2Of | cells,in |
R11604 | T17708 | T17705 | arg1Of | cells,peripheral |
R11605 | T17708 | T17706 | arg1Of | cells,blood |
R11606 | T17708 | T17707 | arg1Of | cells,mononuclear |
R11607 | T17708 | T17709 | arg1Of | cells,of |
R11608 | T17711 | T17709 | arg2Of | patients,of |
R11609 | T17711 | T17710 | arg1Of | patients,RA |
R11610 | T17713 | T17712 | arg2Of | 83,[ |
R11611 | T17714 | T17712 | arg3Of | ],[ |
R11612 | T17715 | T17716 | arg1Of | . miR-14,6a |
R11613 | T17715 | T17718 | arg2Of | . miR-14,lso overexpre |
R11614 | T17718 | T17679 | arg1Of | lso overexpre,Notably |
R11615 | T17718 | T17680 | arg1Of | lso overexpre,"," |
R11616 | T17718 | T17685 | modOf | lso overexpre,are |
R11617 | T17718 | T17716 | arg2Of | lso overexpre,6a |
R11618 | T17718 | T17717 | arg1Of | lso overexpre,is a |
R11619 | T17718 | T17719 | arg1Of | lso overexpre,ss |
R11620 | T17720 | T17721 | arg1Of | ed i,n C |
R11621 | T17722 | T17721 | arg2Of | D4+ and IL-17-p,n C |
R11622 | T17724 | T17719 | arg2Of | oduci,ss |
R11623 | T17724 | T17720 | arg1Of | oduci,ed i |
R11624 | T17724 | T17722 | arg1Of | oduci,D4+ and IL-17-p |
R11625 | T17724 | T17723 | arg1Of | oduci,r |
R11626 | T17724 | T17725 | arg1Of | oduci,ng T |
R11627 | T17727 | T17725 | arg2Of | lls from,ng T |
R11628 | T17727 | T17726 | arg1Of | lls from,ce |
R11629 | T17727 | T17728 | arg1Of | lls from,R |
R11630 | T17729 | T17728 | arg2Of | A pat,R |
R11631 | T17730 | T17728 | arg3Of | i,R |
R11632 | T17734 | T17733 | arg1Of | polymorphism,a |
R11633 | T17734 | T17735 | arg1Of | polymorphism,in |
R11634 | T17734 | T17743 | arg1Of | polymorphism,was |
R11635 | T17734 | T17745 | arg2Of | polymorphism,shown |
R11636 | T17734 | T17747 | arg1Of | polymorphism,be |
R11637 | T17734 | T17748 | arg2Of | polymorphism,associated |
R11638 | T17737 | T17735 | arg2Of | 3'-UTR,in |
R11639 | T17737 | T17736 | arg1Of | 3'-UTR,the |
R11640 | T17737 | T17738 | arg1Of | 3'-UTR,of |
R11641 | T17742 | T17738 | arg2Of | gene,of |
R11642 | T17742 | T17739 | arg1Of | gene,the |
R11643 | T17742 | T17740 | arg1Of | gene,miR-146a |
R11644 | T17742 | T17741 | arg1Of | gene,target |
R11645 | T17745 | T17731 | arg1Of | shown,Interestingly |
R11646 | T17745 | T17732 | arg1Of | shown,"," |
R11647 | T17745 | T17743 | arg2Of | shown,was |
R11648 | T17745 | T17744 | arg1Of | shown,recently |
R11649 | T17748 | T17745 | arg3Of | associated,shown |
R11650 | T17748 | T17746 | arg1Of | associated,to |
R11651 | T17748 | T17747 | arg2Of | associated,be |
R11652 | T17748 | T17749 | arg1Of | associated,with |
R11653 | T17748 | T17757 | arg1Of | associated,io |
R11654 | T17753 | T17752 | arg2Of | 86,[ |
R11655 | T17754 | T17752 | arg3Of | ],[ |
R11656 | T17756 | T17749 | arg2Of | 55 overexpress,with |
R11657 | T17756 | T17750 | arg1Of | 55 overexpress,RA |
R11658 | T17756 | T17751 | arg1Of | 55 overexpress,susceptibility |
R11659 | T17756 | T17752 | arg1Of | 55 overexpress,[ |
R11660 | T17756 | T17755 | arg1Of | 55 overexpress,. miR-1 |
R11661 | T17759 | T17758 | arg1Of | ovial fibro,n in syn |
R11662 | T17759 | T17760 | arg1Of | ovial fibro,bla |
R11663 | T17759 | T17761 | arg1Of | ovial fibro,sts |
R11664 | T17759 | T17763 | arg1Of | ovial fibro,s able |
R11665 | T17760 | T17757 | arg2Of | bla,io |
R11666 | T17761 | T17760 | arg2Of | sts ,bla |
R11667 | T17763 | T17761 | arg2Of | s able ,sts |
R11668 | T17763 | T17762 | arg1Of | s able ,wa |
R11669 | T17765 | T17766 | arg1Of | pre,ven |
R11670 | T17767 | T17766 | arg2Of | t the TLR and cyto,ven |
R11671 | T17768 | T17763 | arg2Of | kine-induc,s able |
R11672 | T17768 | T17764 | arg1Of | kine-induc,to |
R11673 | T17768 | T17765 | arg1Of | kine-induc,pre |
R11674 | T17768 | T17767 | arg1Of | kine-induc,t the TLR and cyto |
R11675 | T17768 | T17769 | arg1Of | kine-induc,ib |
R11676 | T17772 | T17769 | arg2Of | of specific matrix,ib |
R11677 | T17772 | T17770 | arg1Of | of specific matrix,le expre |
R11678 | T17772 | T17771 | arg1Of | of specific matrix,ssion |
R11679 | T17772 | T17773 | arg1Of | of specific matrix,meta |
R11680 | T17772 | T17774 | arg1Of | of specific matrix,lloprot |
R11681 | T17774 | T17777 | arg1Of | lloprot,at |
R11682 | T17774 | T17779 | arg1Of | lloprot,t |
R11683 | T17776 | T17774 | arg2Of | s that medi,lloprot |
R11684 | T17776 | T17775 | arg1Of | s that medi,einase |
R11685 | T17778 | T17777 | arg2Of | e ,at |
R11686 | T17780 | T17779 | arg2Of | is,t |
R11687 | T17781 | T17779 | arg3Of | s,t |
R11688 | T17784 | T17785 | arg1Of | miR-155,was |
R11689 | T17784 | T17786 | arg2Of | miR-155,shown |
R11690 | T17784 | T17788 | arg1Of | miR-155,promote |
R11691 | T17786 | T17785 | arg2Of | shown,was |
R11692 | T17786 | T17804 | arg1Of | shown,46 |
R11693 | T17788 | T17786 | arg3Of | promote,shown |
R11694 | T17788 | T17787 | arg1Of | promote,to |
R11695 | T17788 | T17795 | arg1Of | promote,in |
R11696 | T17790 | T17788 | arg2Of | production,promote |
R11697 | T17790 | T17789 | arg1Of | production,TNF |
R11698 | T17790 | T17791 | arg1Of | production,"," |
R11699 | T17794 | T17791 | arg2Of | process,"," |
R11700 | T17794 | T17792 | arg1Of | process,a |
R11701 | T17794 | T17793 | arg1Of | process,key |
R11702 | T17797 | T17795 | arg2Of | pathogenesis,in |
R11703 | T17797 | T17796 | arg1Of | pathogenesis,the |
R11704 | T17797 | T17798 | arg1Of | pathogenesis,of |
R11705 | T17799 | T17798 | arg2Of | RA,of |
R11706 | T17801 | T17800 | arg2Of | 87,[ |
R11707 | T17802 | T17800 | arg3Of | ],[ |
R11708 | T17803 | T17795 | arg3Of | . miR-1,in |
R11709 | T17803 | T17800 | arg1Of | . miR-1,[ |
R11710 | T17804 | T17816 | arg1Of | 46 ,mma |
R11711 | T17805 | T17806 | arg1Of | and miR,-15 |
R11712 | T17805 | T17808 | arg1Of | and miR,re |
R11713 | T17808 | T17804 | arg2Of | re,46 |
R11714 | T17808 | T17806 | arg2Of | re,-15 |
R11715 | T17808 | T17807 | arg1Of | re,5 may the |
R11716 | T17810 | T17809 | arg1Of | mportant,fore be i |
R11717 | T17811 | T17808 | arg2Of | negative r,re |
R11718 | T17811 | T17810 | arg1Of | negative r,mportant |
R11719 | T17811 | T17812 | arg1Of | negative r,eg |
R11720 | T17811 | T17814 | arg1Of | negative r,nf |
R11721 | T17813 | T17812 | arg2Of | ulators of i,eg |
R11722 | T17815 | T17814 | arg2Of | la,nf |
R11723 | T17816 | T17782 | arg1Of | mma,Moreover |
R11724 | T17816 | T17783 | arg1Of | mma,"," |
R11725 | T17818 | T17817 | arg1Of | in RA and,tion |
R11726 | T17818 | T17819 | arg1Of | in RA and,the |
R11727 | T17818 | T17825 | arg1Of | in RA and,t |
R11728 | T17818 | T17826 | arg1Of | in RA and,of new trea |
R11729 | T17821 | T17819 | arg2Of | potential f,the |
R11730 | T17821 | T17820 | arg1Of | potential f,ir |
R11731 | T17821 | T17822 | arg1Of | potential f,or |
R11732 | T17824 | T17822 | arg2Of | developmen,or |
R11733 | T17824 | T17823 | arg1Of | developmen,the |
R11734 | T17825 | T17816 | arg2Of | t ,mma |
R11735 | T17826 | T17825 | arg2Of | of new trea,t |
R11736 | T17828 | T17827 | arg2Of | addition,In |
R11737 | T17832 | T17830 | arg1Of | expression,their |
R11738 | T17832 | T17831 | arg2Of | expression,increased |
R11739 | T17832 | T17833 | arg1Of | expression,in |
R11740 | T17832 | T17836 | arg1Of | expression,is |
R11741 | T17832 | T17838 | arg1Of | expression,useful |
R11742 | T17835 | T17833 | arg2Of | patients,in |
R11743 | T17835 | T17834 | arg1Of | patients,RA |
R11744 | T17836 | T17851 | arg1Of | is,[ |
R11745 | T17836 | T17855 | arg1Of | is,but |
R11746 | T17838 | T17836 | arg2Of | useful,is |
R11747 | T17838 | T17837 | arg1Of | useful,potentially |
R11748 | T17838 | T17839 | arg1Of | useful,as |
R11749 | T17841 | T17839 | arg2Of | marker,as |
R11750 | T17841 | T17840 | arg1Of | marker,a |
R11751 | T17841 | T17842 | arg1Of | marker,for |
R11752 | T17844 | T17843 | arg1Of | diagnosis,disease |
R11753 | T17844 | T17845 | arg1Of | diagnosis,"," |
R11754 | T17845 | T17848 | arg1Of | ",",or |
R11755 | T17846 | T17845 | arg2Of | progression,"," |
R11756 | T17848 | T17842 | arg2Of | or,for |
R11757 | T17848 | T17847 | arg1Of | or,"," |
R11758 | T17850 | T17848 | arg2Of | efficacy,or |
R11759 | T17850 | T17849 | arg1Of | efficacy,treatment |
R11760 | T17852 | T17851 | arg2Of | 88,[ |
R11761 | T17853 | T17851 | arg3Of | ],[ |
R11762 | T17855 | T17827 | arg1Of | but,In |
R11763 | T17855 | T17829 | arg1Of | but,"," |
R11764 | T17855 | T17854 | arg1Of | but,"," |
R11765 | T17856 | T17857 | arg1Of | this,will |
R11766 | T17856 | T17858 | arg1Of | this,require |
R11767 | T17856 | T17860 | arg1Of | this,using |
R11768 | T17858 | T17855 | arg2Of | require,but |
R11769 | T17858 | T17857 | arg2Of | require,will |
R11770 | T17858 | T17860 | modOf | require,using |
R11771 | T17859 | T17858 | arg2Of | confirmation,require |
R11772 | T17862 | T17863 | arg1Of | large,and |
R11773 | T17864 | T17863 | arg2Of | well-defined,and |
R11774 | T17865 | T17860 | arg2Of | cohort,using |
R11775 | T17865 | T17861 | arg1Of | cohort,a |
R11776 | T17865 | T17862 | arg1Of | cohort,large |
R11777 | T17865 | T17864 | arg1Of | cohort,well-defined |
R11778 | T17867 | T17868 | arg1Of | miR-146,and |
R11779 | T17868 | T17866 | arg2Of | and,Besides |
R11780 | T17869 | T17868 | arg2Of | miR-155,and |
R11781 | T17872 | T17871 | arg1Of | number,a |
R11782 | T17872 | T17873 | arg1Of | number,of |
R11783 | T17872 | T17876 | arg1Of | number,with |
R11784 | T17872 | T17890 | arg1Of | number,were |
R11785 | T17872 | T17892 | arg2Of | number,identified |
R11786 | T17875 | T17873 | arg2Of | miRNAs,of |
R11787 | T17875 | T17874 | arg1Of | miRNAs,other |
R11788 | T17879 | T17876 | arg2Of | role,with |
R11789 | T17879 | T17877 | arg1Of | role,a |
R11790 | T17879 | T17878 | arg1Of | role,potential |
R11791 | T17879 | T17880 | arg1Of | role,in |
R11792 | T17879 | T17887 | arg1Of | role,in |
R11793 | T17882 | T17880 | arg2Of | control,in |
R11794 | T17882 | T17881 | arg1Of | control,the |
R11795 | T17882 | T17883 | arg1Of | control,of |
R11796 | T17886 | T17883 | arg2Of | responses,of |
R11797 | T17886 | T17884 | arg1Of | responses,NF-κB-dependent |
R11798 | T17886 | T17885 | arg1Of | responses,inflammatory |
R11799 | T17889 | T17887 | arg2Of | pathology,in |
R11800 | T17889 | T17888 | arg1Of | pathology,RA |
R11801 | T17892 | T17866 | arg1Of | identified,Besides |
R11802 | T17892 | T17870 | arg1Of | identified,"," |
R11803 | T17892 | T17890 | arg2Of | identified,were |
R11804 | T17892 | T17891 | arg1Of | identified,recently |
R11805 | T17895 | T17893 | arg2Of | context,In |
R11806 | T17895 | T17894 | arg1Of | context,this |
R11807 | T17897 | T17898 | arg1Of | miR-124a,- |
R11808 | T17897 | T17910 | arg1Of | miR-124a,was |
R11809 | T17897 | T17911 | arg2Of | miR-124a,shown |
R11810 | T17897 | T17913 | arg1Of | miR-124a,be |
R11811 | T17897 | T17914 | arg2Of | miR-124a,decreased |
R11812 | T17901 | T17898 | arg2Of | regulator,- |
R11813 | T17901 | T17899 | arg1Of | regulator,a |
R11814 | T17901 | T17900 | arg1Of | regulator,key |
R11815 | T17901 | T17902 | arg1Of | regulator,of |
R11816 | T17907 | T17902 | arg2Of | protein,of |
R11817 | T17907 | T17903 | arg1Of | protein,the |
R11818 | T17907 | T17904 | arg1Of | protein,chemokine |
R11819 | T17907 | T17905 | arg1Of | protein,monocyte |
R11820 | T17907 | T17906 | arg1Of | protein,chemoattractant |
R11821 | T17907 | T17908 | arg1Of | protein,1 |
R11822 | T17909 | T17898 | arg3Of | -,- |
R11823 | T17911 | T17893 | arg1Of | shown,In |
R11824 | T17911 | T17896 | arg1Of | shown,"," |
R11825 | T17911 | T17910 | arg2Of | shown,was |
R11826 | T17914 | T17911 | arg3Of | decreased,shown |
R11827 | T17914 | T17912 | arg1Of | decreased,to |
R11828 | T17914 | T17913 | arg2Of | decreased,be |
R11829 | T17914 | T17915 | arg1Of | decreased,in |
R11830 | T17916 | T17915 | arg2Of | synoviocytes,in |
R11831 | T17916 | T17917 | arg1Of | synoviocytes,from |
R11832 | T17919 | T17917 | arg2Of | patients,from |
R11833 | T17919 | T17918 | arg1Of | patients,RA |
R11834 | T17919 | T17920 | arg1Of | patients,[ |
R11835 | T17921 | T17920 | arg2Of | 89,[ |
R11836 | T17922 | T17920 | arg3Of | ],[ |
R11837 | T17926 | T17925 | arg1Of | levels,elevated |
R11838 | T17926 | T17927 | arg1Of | levels,of |
R11839 | T17926 | T17929 | arg1Of | levels,- |
R11840 | T17926 | T17930 | arg1Of | levels,leading |
R11841 | T17926 | T17939 | arg1Of | levels,- |
R11842 | T17926 | T17940 | arg1Of | levels,were |
R11843 | T17926 | T17941 | arg2Of | levels,detected |
R11844 | T17928 | T17927 | arg2Of | miR-203,of |
R11845 | T17930 | T17931 | arg1Of | leading,to |
R11846 | T17933 | T17931 | arg2Of | secretion,to |
R11847 | T17933 | T17932 | arg2Of | secretion,increased |
R11848 | T17933 | T17934 | arg1Of | secretion,of |
R11849 | T17936 | T17935 | arg1Of | metalloproteinase-1,matrix |
R11850 | T17936 | T17937 | arg1Of | metalloproteinase-1,and |
R11851 | T17937 | T17934 | arg2Of | and,of |
R11852 | T17938 | T17937 | arg2Of | IL-6,and |
R11853 | T17941 | T17923 | arg1Of | detected,Similarly |
R11854 | T17941 | T17924 | arg1Of | detected,"," |
R11855 | T17941 | T17940 | arg2Of | detected,were |
R11856 | T17941 | T17942 | arg1Of | detected,in |
R11857 | T17941 | T17946 | arg1Of | detected,[ |
R11858 | T17945 | T17942 | arg2Of | fibroblasts,in |
R11859 | T17945 | T17943 | arg1Of | fibroblasts,RA |
R11860 | T17945 | T17944 | arg1Of | fibroblasts,synovial |
R11861 | T17947 | T17946 | arg2Of | 90,[ |
R11862 | T17948 | T17946 | arg3Of | ],[ |
R11863 | T17951 | T17952 | arg1Of | miR-16,"," |
R11864 | T17952 | T17955 | arg1Of | ",",and |
R11865 | T17953 | T17952 | arg2Of | miR-132,"," |
R11866 | T17955 | T17954 | arg1Of | and,"," |
R11867 | T17955 | T17957 | arg1Of | and,were |
R11868 | T17955 | T17959 | arg2Of | and,shown |
R11869 | T17955 | T17961 | arg1Of | and,have |
R11870 | T17956 | T17955 | arg2Of | miR-223,and |
R11871 | T17959 | T17949 | arg1Of | shown,Finally |
R11872 | T17959 | T17950 | arg1Of | shown,"," |
R11873 | T17959 | T17957 | arg2Of | shown,were |
R11874 | T17959 | T17958 | arg1Of | shown,also |
R11875 | T17959 | T17968 | arg1Of | shown,"," |
R11876 | T17959 | T17969 | modOf | shown,indicating |
R11877 | T17961 | T17959 | arg3Of | have,shown |
R11878 | T17961 | T17960 | arg1Of | have,to |
R11879 | T17964 | T17961 | arg2Of | expression,have |
R11880 | T17964 | T17962 | arg1Of | expression,an |
R11881 | T17964 | T17963 | arg2Of | expression,altered |
R11882 | T17964 | T17965 | arg1Of | expression,in |
R11883 | T17967 | T17965 | arg2Of | patients,in |
R11884 | T17967 | T17966 | arg1Of | patients,RA |
R11885 | T17971 | T17969 | arg2Of | potential,indicating |
R11886 | T17971 | T17970 | arg1Of | potential,their |
R11887 | T17971 | T17972 | arg1Of | potential,as |
R11888 | T17974 | T17972 | arg2Of | biomarkers,as |
R11889 | T17974 | T17973 | arg1Of | biomarkers,diagnostic |
R11890 | T17974 | T17975 | arg1Of | biomarkers,for |
R11891 | T17976 | T17975 | arg2Of | pathogenesis,for |
R11892 | T17976 | T17977 | arg1Of | pathogenesis,[ |
R11893 | T17978 | T17977 | arg2Of | "83,88,91",[ |
R11894 | T17979 | T17977 | arg3Of | ],[ |
R12465 | T18905 | T18903 | arg1Of | family,The |
R12466 | T18905 | T18904 | arg1Of | family,NF-κB |
R12467 | T18905 | T18906 | arg1Of | family,of |
R12468 | T18905 | T18909 | arg1Of | family,plays |
R12469 | T18908 | T18906 | arg2Of | factors,of |
R12470 | T18908 | T18907 | arg1Of | factors,transcription |
R12471 | T18909 | T18912 | arg1Of | plays,in |
R12472 | T18911 | T18909 | arg2Of | roles,plays |
R12473 | T18911 | T18910 | arg1Of | roles,crucial |
R12474 | T18915 | T18912 | arg2Of | processes,in |
R12475 | T18915 | T18913 | arg1Of | processes,the |
R12476 | T18915 | T18914 | arg1Of | processes,inflammatory |
R12477 | T18915 | T18916 | arg1Of | processes,in |
R12478 | T18915 | T18918 | arg1Of | processes,leading |
R12479 | T18917 | T18916 | arg2Of | RA,in |
R12480 | T18918 | T18919 | arg1Of | leading,to |
R12481 | T18920 | T18921 | arg1Of | cartilage,and |
R12482 | T18922 | T18921 | arg2Of | bone,and |
R12483 | T18923 | T18919 | arg2Of | destruction,to |
R12484 | T18923 | T18920 | arg1Of | destruction,cartilage |
R12485 | T18923 | T18922 | arg1Of | destruction,bone |
R12486 | T18926 | T18924 | arg1Of | activation,Keeping |
R12487 | T18926 | T18925 | arg1Of | activation,NF-κB |
R12488 | T18926 | T18927 | arg1Of | activation,under |
R12489 | T18926 | T18929 | arg1Of | activation,can |
R12490 | T18926 | T18931 | arg1Of | activation,be |
R12491 | T18926 | T18933 | arg1Of | activation,important |
R12492 | T18928 | T18927 | arg2Of | control,under |
R12493 | T18931 | T18929 | arg2Of | be,can |
R12494 | T18931 | T18930 | arg1Of | be,thus |
R12495 | T18933 | T18931 | arg2Of | important,be |
R12496 | T18933 | T18932 | arg1Of | important,very |
R12497 | T18933 | T18934 | arg1Of | important,for |
R12498 | T18936 | T18934 | arg2Of | design,for |
R12499 | T18936 | T18935 | arg1Of | design,the |
R12500 | T18936 | T18937 | arg1Of | design,of |
R12501 | T18939 | T18937 | arg2Of | therapeutics,of |
R12502 | T18939 | T18938 | arg1Of | therapeutics,specific |
R12503 | T18941 | T18940 | arg1Of | existence,The |
R12504 | T18941 | T18942 | arg1Of | existence,of |
R12505 | T18941 | T18957 | arg1Of | existence,raises |
R12506 | T18945 | T18942 | arg2Of | regulators,of |
R12507 | T18945 | T18943 | arg1Of | regulators,multiple |
R12508 | T18945 | T18944 | arg1Of | regulators,negative |
R12509 | T18945 | T18946 | arg1Of | regulators,ensuring |
R12510 | T18949 | T18946 | arg2Of | regulation,ensuring |
R12511 | T18949 | T18947 | arg1Of | regulation,a |
R12512 | T18949 | T18948 | arg1Of | regulation,tight |
R12513 | T18949 | T18950 | arg1Of | regulation,of |
R12514 | T18953 | T18950 | arg2Of | pathway,of |
R12515 | T18953 | T18951 | arg1Of | pathway,the |
R12516 | T18953 | T18952 | arg1Of | pathway,NF-κB |
R12517 | T18957 | T18954 | arg1Of | raises,"," |
R12518 | T18957 | T18955 | arg1Of | raises,however |
R12519 | T18957 | T18956 | arg1Of | raises,"," |
R12520 | T18959 | T18958 | arg1Of | question,the |
R12521 | T18959 | T18960 | arg1Of | question,of |
R12522 | T18959 | T18969 | arg1Of | question,and |
R12523 | T18963 | T18960 | arg2Of | role,of |
R12524 | T18963 | T18961 | arg1Of | role,the |
R12525 | T18963 | T18962 | arg1Of | role,specific |
R12526 | T18963 | T18964 | arg1Of | role,of |
R12527 | T18965 | T18964 | arg2Of | each,of |
R12528 | T18965 | T18966 | arg1Of | each,of |
R12529 | T18968 | T18966 | arg2Of | regulators,of |
R12530 | T18968 | T18967 | arg1Of | regulators,these |
R12531 | T18969 | T18957 | arg2Of | and,raises |
R12532 | T18971 | T18969 | arg2Of | relationship,and |
R12533 | T18971 | T18970 | arg1Of | relationship,the |
R12534 | T18971 | T18972 | arg1Of | relationship,between |
R12535 | T18973 | T18972 | arg2Of | them,between |
R12536 | T18975 | T18974 | arg2Of | addition,In |
R12547 | T18987 | T18989 | arg2Of | mRNAs,target |
R12548 | T18988 | T18989 | arg1Of | they,target |
R12549 | T18992 | T18991 | arg1Of | complexity,intense |
R12550 | T18992 | T18993 | arg1Of | complexity,can |
R12551 | T18992 | T18994 | arg1Of | complexity,be |
R12552 | T18992 | T18995 | arg2Of | complexity,expected |
R12553 | T18995 | T18974 | arg1Of | expected,In |
R12554 | T18995 | T18976 | arg1Of | expected,"," |
R12555 | T18995 | T18977 | arg1Of | expected,given |
R12556 | T18995 | T18990 | arg1Of | expected,"," |
R12557 | T18995 | T18993 | arg2Of | expected,can |
R12558 | T18995 | T18994 | arg2Of | expected,be |
R12559 | T18996 | T19004 | arg1Of | How,will |
R12560 | T18996 | T19005 | arg1Of | How,be |
R12561 | T18996 | T19012 | arg1Of | How,clarify |
R12562 | T19000 | T18997 | arg1Of | signals,all |
R12563 | T19000 | T18998 | arg1Of | signals,these |
R12564 | T19000 | T18999 | arg1Of | signals,regulatory |
R12565 | T19000 | T19001 | arg1Of | signals,are |
R12566 | T19001 | T18996 | arg1Of | are,How |
R12567 | T19002 | T19003 | arg1Of | themselves,regulated |
R12568 | T19005 | T19003 | arg2Of | be,regulated |
R12569 | T19005 | T19004 | arg2Of | be,will |
R12570 | T19005 | T19009 | arg1Of | be,in |
R12571 | T19008 | T19005 | arg2Of | question,be |
R12572 | T19008 | T19006 | arg1Of | question,an |
R12573 | T19008 | T19007 | arg1Of | question,important |
R12574 | T19010 | T19009 | arg2Of | order,in |
R12575 | T19012 | T19009 | arg3Of | clarify,in |
R12576 | T19012 | T19011 | arg1Of | clarify,to |
R12577 | T19012 | T19018 | arg1Of | clarify,"," |
R12578 | T19012 | T19019 | arg1Of | clarify,and |
R12579 | T19012 | T19020 | arg1Of | clarify,"," |
R12580 | T19012 | T19022 | arg1Of | clarify,importantly |
R12581 | T19012 | T19023 | arg1Of | clarify,"," |
R12582 | T19013 | T19012 | arg2Of | how,clarify |
R12583 | T19015 | T19014 | arg1Of | signalling,NF-κB |
R12584 | T19015 | T19016 | arg1Of | signalling,is |
R12585 | T19015 | T19017 | arg2Of | signalling,organised |
R12586 | T19017 | T19013 | arg1Of | organised,how |
R12587 | T19017 | T19016 | arg2Of | organised,is |
R12588 | T19022 | T19021 | arg1Of | importantly,more |
R12589 | T19024 | T19012 | arg3Of | how,clarify |
R12590 | T19026 | T19025 | arg1Of | knowledge,this |
R12591 | T19026 | T19027 | arg1Of | knowledge,may |
R12592 | T19026 | T19028 | arg1Of | knowledge,lead |
R12593 | T19028 | T19024 | arg1Of | lead,how |
R12594 | T19028 | T19027 | arg2Of | lead,may |
R12595 | T19028 | T19029 | arg1Of | lead,to |
R12596 | T19031 | T19029 | arg2Of | treatments,to |
R12597 | T19031 | T19030 | arg1Of | treatments,new |
R12598 | T19031 | T19032 | arg1Of | treatments,for |
R12599 | T19034 | T19032 | arg2Of | diseases,for |
R12600 | T19034 | T19033 | arg1Of | diseases,inflammatory |
R12601 | T19034 | T19036 | arg1Of | diseases,as |
R12602 | T19036 | T19035 | arg1Of | as,such |
R12603 | T19037 | T19036 | arg2Of | RA,as |
R12928 | T19642 | T19640 | arg1Of | signalling,Canonical |
R12929 | T19642 | T19641 | arg1Of | signalling,NF-κB |
R12930 | T19642 | T19643 | arg1Of | signalling,and |
R12931 | T19645 | T19643 | arg2Of | regulators,and |
R12932 | T19645 | T19644 | arg1Of | regulators,negative |
R12933 | T19647 | T19646 | arg1Of | engagement,Ligand |
R12934 | T19647 | T19648 | arg1Of | engagement,of |
R12935 | T19647 | T19662 | arg1Of | engagement,trigger |
R12936 | T19651 | T19648 | arg2Of | receptors,of |
R12937 | T19651 | T19649 | arg1Of | receptors,specific |
R12938 | T19651 | T19650 | arg1Of | receptors,membrane |
R12939 | T19651 | T19653 | arg1Of | receptors,as |
R12940 | T19653 | T19652 | arg1Of | as,such |
R12941 | T19654 | T19655 | arg1Of | TNFR1,"," |
R12942 | T19655 | T19657 | arg1Of | ",","," |
R12943 | T19656 | T19655 | arg2Of | CD40,"," |
R12944 | T19657 | T19660 | arg1Of | ",",and |
R12945 | T19658 | T19657 | arg2Of | RANK,"," |
R12946 | T19660 | T19653 | arg2Of | and,as |
R12947 | T19660 | T19659 | arg1Of | and,"," |
R12948 | T19661 | T19660 | arg2Of | TLR4,and |
R12949 | T19664 | T19662 | arg2Of | recruitment,trigger |
R12950 | T19664 | T19663 | arg1Of | recruitment,the |
R12951 | T19664 | T19665 | arg1Of | recruitment,of |
R12952 | T19668 | T19666 | arg1Of | proteins,specific |
R12953 | T19668 | T19667 | arg1Of | proteins,adaptor |
R12954 | T19668 | T19669 | arg1Of | proteins,( |
R12955 | T19668 | T19692 | arg1Of | proteins,"," |
R12956 | T19675 | T19670 | arg1Of | protein,TNF |
R12957 | T19675 | T19671 | arg1Of | protein,receptor |
R12958 | T19675 | T19672 | arg1Of | protein,1-associated |
R12959 | T19675 | T19673 | arg1Of | protein,death |
R12960 | T19675 | T19674 | arg1Of | protein,domain |
R12961 | T19675 | T19676 | arg1Of | protein,( |
R12962 | T19675 | T19679 | arg1Of | protein,"," |
R12963 | T19677 | T19676 | arg2Of | TRADD,( |
R12964 | T19678 | T19676 | arg3Of | ),( |
R12965 | T19679 | T19681 | arg1Of | ",","," |
R12966 | T19680 | T19679 | arg2Of | MyD88,"," |
R12967 | T19681 | T19683 | arg1Of | ",","," |
R12968 | T19682 | T19681 | arg2Of | MAL,"," |
R12969 | T19683 | T19669 | arg2Of | ",",( |
R12970 | T19687 | T19683 | arg2Of | IFNβ,"," |
R12971 | T19687 | T19684 | arg1Of | IFNβ,TIR |
R12972 | T19687 | T19685 | arg1Of | IFNβ,domain-containing |
R12973 | T19687 | T19686 | arg1Of | IFNβ,adaptor-inducing |
R12974 | T19687 | T19688 | arg1Of | IFNβ,( |
R12975 | T19689 | T19688 | arg2Of | TRIF,( |
R12976 | T19690 | T19688 | arg3Of | ),( |
R12977 | T19691 | T19669 | arg3Of | ),( |
R12978 | T19692 | T19665 | arg2Of | ",",of |
R12979 | T19692 | T19714 | arg1Of | ",",to |
R12980 | T19693 | T19694 | arg1Of | kinases,( |
R12981 | T19693 | T19702 | arg1Of | kinases,and |
R12982 | T19695 | T19694 | arg2Of | RIP1,( |
R12983 | T19695 | T19696 | arg1Of | RIP1,"," |
R12984 | T19695 | T19698 | arg1Of | RIP1,"," |
R12985 | T19697 | T19696 | arg2Of | IRAK1,"," |
R12986 | T19699 | T19698 | arg2Of | IRAK4,"," |
R12987 | T19700 | T19694 | arg3Of | ),( |
R12988 | T19702 | T19692 | arg2Of | and,"," |
R12989 | T19702 | T19701 | arg1Of | and,"," |
R12990 | T19704 | T19702 | arg2Of | ligases,and |
R12991 | T19704 | T19703 | arg1Of | ligases,ubiquitin |
R12992 | T19704 | T19705 | arg1Of | ligases,( |
R12993 | T19706 | T19707 | arg1Of | TRAF2,"," |
R12994 | T19707 | T19709 | arg1Of | ",","," |
R12995 | T19708 | T19707 | arg2Of | TRAF6,"," |
R12996 | T19709 | T19705 | arg2Of | ",",( |
R12997 | T19709 | T19711 | arg1Of | ",","," |
R12998 | T19710 | T19709 | arg2Of | cIAP1,"," |
R12999 | T19712 | T19711 | arg2Of | cIAP2,"," |
R13000 | T19713 | T19705 | arg3Of | ),( |
R13001 | T19716 | T19714 | arg2Of | receptor,to |
R13002 | T19716 | T19715 | arg1Of | receptor,the |
R13003 | T19718 | T19717 | arg1Of | polyubiquitination,K63-linked |
R13004 | T19718 | T19719 | arg1Of | polyubiquitination,of |
R13005 | T19718 | T19726 | arg1Of | polyubiquitination,is |
R13006 | T19718 | T19727 | arg2Of | polyubiquitination,recognised |
R13007 | T19720 | T19719 | arg2Of | TRAFs,of |
R13008 | T19720 | T19721 | arg1Of | TRAFs,"," |
R13009 | T19722 | T19723 | arg1Of | RIP1,and |
R13010 | T19723 | T19721 | arg2Of | and,"," |
R13011 | T19724 | T19723 | arg2Of | IRAK1,and |
R13012 | T19727 | T19725 | arg1Of | recognised,"," |
R13013 | T19727 | T19726 | arg2Of | recognised,is |
R13014 | T19727 | T19733 | arg1Of | recognised,"," |
R13015 | T19727 | T19734 | modOf | recognised,resulting |
R13016 | T19729 | T19730 | arg1Of | NEMO,and |
R13017 | T19731 | T19730 | arg2Of | TAB,and |
R13018 | T19732 | T19727 | arg1Of | proteins,recognised |
R13019 | T19732 | T19728 | arg2Of | proteins,by |
R13020 | T19732 | T19729 | arg1Of | proteins,NEMO |
R13021 | T19732 | T19731 | arg1Of | proteins,TAB |
R13022 | T19734 | T19735 | arg1Of | resulting,in |
R13023 | T19737 | T19738 | arg1Of | recruitment,and |
R13024 | T19738 | T19735 | arg2Of | and,in |
R13025 | T19738 | T19736 | arg1Of | and,the |
R13026 | T19738 | T19740 | arg1Of | and,of |
R13027 | T19739 | T19738 | arg2Of | activation,and |
R13028 | T19742 | T19743 | arg1Of | IKK2,and |
R13029 | T19743 | T19740 | arg2Of | and,of |
R13030 | T19743 | T19741 | arg1Of | and,respectively |
R13031 | T19744 | T19743 | arg2Of | TAK1,and |
R13032 | T19745 | T19747 | arg1Of | TAK1,phosphorylates |
R13033 | T19745 | T19749 | arg1Of | TAK1,activates |
R13034 | T19747 | T19748 | arg1Of | phosphorylates,and |
R13035 | T19748 | T19746 | arg1Of | and,then |
R13036 | T19749 | T19748 | arg2Of | activates,and |
R13037 | T19750 | T19747 | arg2Of | IKK2,phosphorylates |
R13038 | T19750 | T19749 | arg2Of | IKK2,activates |
R13039 | T19750 | T19751 | arg1Of | IKK2,"," |
R13040 | T19750 | T19752 | arg1Of | IKK2,which |
R13041 | T19750 | T19755 | arg1Of | IKK2,phosphorylates |
R13042 | T19750 | T19758 | arg1Of | IKK2,triggering |
R13043 | T19754 | T19753 | arg2Of | turn,in |
R13044 | T19755 | T19753 | arg1Of | phosphorylates,in |
R13045 | T19755 | T19757 | arg1Of | phosphorylates,"," |
R13046 | T19755 | T19758 | modOf | phosphorylates,triggering |
R13047 | T19756 | T19755 | arg2Of | IκBα,phosphorylates |
R13048 | T19761 | T19760 | arg1Of | ubiquitination,K48-linked |
R13049 | T19761 | T19762 | arg1Of | ubiquitination,and |
R13050 | T19762 | T19758 | arg2Of | and,triggering |
R13051 | T19762 | T19759 | arg1Of | and,its |
R13052 | T19764 | T19762 | arg2Of | degradation,and |
R13053 | T19764 | T19763 | arg1Of | degradation,proteasomal |
R13054 | T19765 | T19766 | arg1Of | This,allows |
R13055 | T19767 | T19766 | arg2Of | NF-κB,allows |
R13056 | T19767 | T19768 | arg1Of | NF-κB,( |
R13057 | T19767 | T19780 | arg1Of | NF-κB,translocate |
R13058 | T19767 | T19785 | arg1Of | NF-κB,promote |
R13059 | T19770 | T19768 | arg2Of | shown,( |
R13060 | T19770 | T19769 | arg1Of | shown,here |
R13061 | T19770 | T19771 | arg1Of | shown,as |
R13062 | T19773 | T19771 | arg2Of | heterodimer,as |
R13063 | T19773 | T19772 | arg1Of | heterodimer,a |
R13064 | T19773 | T19774 | arg1Of | heterodimer,of |
R13065 | T19775 | T19776 | arg1Of | p65,and |
R13066 | T19776 | T19774 | arg2Of | and,of |
R13067 | T19777 | T19776 | arg2Of | p50,and |
R13068 | T19778 | T19768 | arg3Of | ),( |
R13069 | T19780 | T19781 | arg1Of | translocate,to |
R13070 | T19780 | T19784 | arg1Of | translocate,and |
R13071 | T19783 | T19781 | arg2Of | nucleus,to |
R13072 | T19783 | T19782 | arg1Of | nucleus,the |
R13073 | T19784 | T19766 | arg3Of | and,allows |
R13074 | T19784 | T19779 | arg1Of | and,to |
R13075 | T19785 | T19784 | arg2Of | promote,and |
R13076 | T19788 | T19785 | arg2Of | expression,promote |
R13077 | T19788 | T19786 | arg1Of | expression,target |
R13078 | T19788 | T19787 | arg1Of | expression,gene |
R13079 | T19789 | T19790 | arg1Of | TRAF1,"," |
R13080 | T19789 | T19791 | arg1Of | TRAF1,which |
R13081 | T19789 | T19792 | arg1Of | TRAF1,has |
R13082 | T19789 | T19798 | arg1Of | TRAF1,can |
R13083 | T19789 | T19800 | arg1Of | TRAF1,regulate |
R13084 | T19789 | T19807 | arg1Of | TRAF1,competing |
R13085 | T19796 | T19792 | arg2Of | activity,has |
R13086 | T19796 | T19793 | arg1Of | activity,no |
R13087 | T19796 | T19794 | arg1Of | activity,ubiquitin |
R13088 | T19796 | T19795 | arg1Of | activity,ligase |
R13089 | T19800 | T19797 | arg1Of | regulate,"," |
R13090 | T19800 | T19798 | arg2Of | regulate,can |
R13091 | T19800 | T19799 | arg1Of | regulate,negatively |
R13092 | T19800 | T19803 | arg1Of | regulate,"," |
R13093 | T19800 | T19806 | arg1Of | regulate,by |
R13094 | T19802 | T19800 | arg2Of | activation,regulate |
R13095 | T19802 | T19801 | arg1Of | activation,NF-κB |
R13096 | T19805 | T19804 | arg1Of | probably,most |
R13097 | T19806 | T19805 | arg1Of | by,probably |
R13098 | T19807 | T19806 | arg2Of | competing,by |
R13099 | T19807 | T19808 | arg1Of | competing,with |
R13100 | T19810 | T19808 | arg2Of | TRAFs,with |
R13101 | T19810 | T19809 | arg1Of | TRAFs,other |
R13102 | T19811 | T19812 | arg1Of | A20,and |
R13103 | T19812 | T19814 | arg1Of | and,are |
R13104 | T19812 | T19815 | arg1Of | and,deubiquitinating |
R13105 | T19813 | T19812 | arg2Of | CYLD,and |
R13106 | T19815 | T19814 | arg2Of | deubiquitinating,are |
R13107 | T19816 | T19815 | arg2Of | enzymes,deubiquitinating |
R13108 | T19816 | T19817 | arg1Of | enzymes,that |
R13109 | T19816 | T19818 | arg1Of | enzymes,control |
R13110 | T19816 | T19822 | arg1Of | enzymes,targeting |
R13111 | T19818 | T19821 | arg1Of | control,by |
R13112 | T19820 | T19818 | arg2Of | activation,control |
R13113 | T19820 | T19819 | arg1Of | activation,NF-κB |
R13114 | T19822 | T19821 | arg2Of | targeting,by |
R13115 | T19825 | T19822 | arg2Of | proteins,targeting |
R13116 | T19825 | T19823 | arg1Of | proteins,specific |
R13117 | T19825 | T19824 | arg1Of | proteins,signalling |
R13118 | T19825 | T19826 | arg1Of | proteins,including |
R13119 | T19827 | T19828 | arg1Of | RIP1,and |
R13120 | T19828 | T19826 | arg2Of | and,including |
R13121 | T19828 | T19830 | arg1Of | and,"," |
R13122 | T19828 | T19831 | arg2Of | and,to |
R13123 | T19828 | T19832 | arg1Of | and,which |
R13124 | T19829 | T19828 | arg2Of | TRAF6,and |
R13125 | T19833 | T19834 | arg1Of | they,are |
R13126 | T19833 | T19835 | arg2Of | they,recruited |
R13127 | T19835 | T19834 | arg2Of | recruited,are |
R13128 | T19835 | T19836 | modOf | recruited,using |
R13129 | T19835 | T19844 | arg1Of | recruited,and |
R13130 | T19840 | T19836 | arg2Of | proteins,using |
R13131 | T19840 | T19837 | arg1Of | proteins,specific |
R13132 | T19840 | T19838 | arg1Of | proteins,ubiquitin-binding |
R13133 | T19840 | T19839 | arg1Of | proteins,adaptor |
R13134 | T19840 | T19842 | arg1Of | proteins,as |
R13135 | T19842 | T19841 | arg1Of | as,such |
R13136 | T19843 | T19842 | arg2Of | ABIN-1,as |
R13137 | T19844 | T19831 | arg1Of | and,to |
R13138 | T19846 | T19845 | arg1Of | miR-146,p62. |
R13139 | T19846 | T19847 | arg1Of | miR-146,is |
R13140 | T19846 | T19848 | arg2Of | miR-146,thought |
R13141 | T19846 | T19851 | arg1Of | miR-146,regulate |
R13142 | T19846 | T19855 | arg1Of | miR-146,inhibiting |
R13143 | T19848 | T19844 | arg2Of | thought,and |
R13144 | T19848 | T19847 | arg2Of | thought,is |
R13145 | T19851 | T19848 | arg3Of | regulate,thought |
R13146 | T19851 | T19849 | arg1Of | regulate,to |
R13147 | T19851 | T19850 | arg1Of | regulate,negatively |
R13148 | T19851 | T19854 | arg1Of | regulate,by |
R13149 | T19853 | T19851 | arg2Of | signalling,regulate |
R13150 | T19853 | T19852 | arg1Of | signalling,TLR |
R13151 | T19855 | T19854 | arg2Of | inhibiting,by |
R13152 | T19856 | T19855 | arg2Of | expression,inhibiting |
R13153 | T19856 | T19857 | arg1Of | expression,of |
R13154 | T19858 | T19859 | arg1Of | IRAK1,and |
R13155 | T19859 | T19857 | arg2Of | and,of |
R13156 | T19860 | T19859 | arg2Of | TRAF6,and |
R13157 | T19864 | T19863 | arg1Of | signalling,TLR |
R13158 | T19864 | T19865 | arg1Of | signalling,can |
R13159 | T19864 | T19867 | arg1Of | signalling,be |
R13160 | T19864 | T19868 | arg2Of | signalling,inhibited |
R13161 | T19868 | T19861 | arg1Of | inhibited,Finally |
R13162 | T19868 | T19862 | arg1Of | inhibited,"," |
R13163 | T19868 | T19865 | arg2Of | inhibited,can |
R13164 | T19868 | T19866 | arg1Of | inhibited,also |
R13165 | T19868 | T19867 | arg2Of | inhibited,be |
R13166 | T19873 | T19868 | arg1Of | SIGIRR,inhibited |
R13167 | T19873 | T19869 | arg2Of | SIGIRR,by |
R13168 | T19873 | T19870 | arg1Of | SIGIRR,the |
R13169 | T19873 | T19871 | arg1Of | SIGIRR,transmembrane |
R13170 | T19873 | T19872 | arg1Of | SIGIRR,protein |
R13171 | T19873 | T19874 | arg1Of | SIGIRR,"," |
R13172 | T19873 | T19875 | arg1Of | SIGIRR,which |
R13173 | T19873 | T19876 | arg1Of | SIGIRR,has |
R13174 | T19873 | T19877 | arg1Of | SIGIRR,been |
R13175 | T19873 | T19878 | arg2Of | SIGIRR,proposed |
R13176 | T19873 | T19880 | arg1Of | SIGIRR,compete |
R13177 | T19878 | T19876 | arg2Of | proposed,has |
R13178 | T19878 | T19877 | arg2Of | proposed,been |
R13179 | T19880 | T19878 | arg3Of | compete,proposed |
R13180 | T19880 | T19879 | arg1Of | compete,to |
R13181 | T19880 | T19881 | arg1Of | compete,with |
R13182 | T19882 | T19881 | arg2Of | TLR4,with |
R13183 | T19882 | T19883 | arg1Of | TLR4,for |
R13184 | T19884 | T19883 | arg2Of | binding,for |
R13185 | T19884 | T19885 | arg1Of | binding,to |
R13186 | T19886 | T19887 | arg1Of | IRAK1,and |
R13187 | T19887 | T19885 | arg2Of | and,to |
R13188 | T19888 | T19887 | arg2Of | TRAF6,and |
R13189 | T19890 | T19889 | arg1Of | expression,The |
R13190 | T19890 | T19891 | arg1Of | expression,of |
R13191 | T19890 | T19898 | arg1Of | expression,is |
R13192 | T19890 | T19902 | arg1Of | expression,implicating |
R13193 | T19892 | T19891 | arg2Of | many,of |
R13194 | T19892 | T19893 | arg1Of | many,of |
R13195 | T19897 | T19893 | arg2Of | molecules,of |
R13196 | T19897 | T19894 | arg1Of | molecules,these |
R13197 | T19897 | T19895 | arg1Of | molecules,negative |
R13198 | T19897 | T19896 | arg1Of | molecules,regulatory |
R13199 | T19898 | T19901 | arg1Of | is,"," |
R13200 | T19898 | T19902 | modOf | is,implicating |
R13201 | T19899 | T19898 | arg2Of | NF-κB,is |
R13202 | T19899 | T19900 | arg1Of | NF-κB,dependent |
R13203 | T19902 | T19904 | arg1Of | implicating,in |
R13204 | T19903 | T19902 | arg2Of | them,implicating |
R13205 | T19908 | T19904 | arg2Of | regulation,in |
R13206 | T19908 | T19905 | arg1Of | regulation,the |
R13207 | T19908 | T19906 | arg1Of | regulation,negative |
R13208 | T19908 | T19907 | arg1Of | regulation,feedback |
R13209 | T19908 | T19909 | arg1Of | regulation,of |
R13210 | T19911 | T19909 | arg2Of | activation,of |
R13211 | T19911 | T19910 | arg1Of | activation,NF-κB |
R13212 | T19912 | T19913 | arg1Of | ABIN,"," |
R13213 | T19912 | T19918 | arg1Of | ABIN,; |
R13214 | T19915 | T19913 | arg2Of | inhibitor,"," |
R13215 | T19915 | T19914 | arg1Of | inhibitor,A20-binding |
R13216 | T19915 | T19916 | arg1Of | inhibitor,of |
R13217 | T19917 | T19916 | arg2Of | NF-κB,of |
R13218 | T19919 | T19918 | arg2Of | cIAP,; |
R13219 | T19919 | T19920 | arg1Of | cIAP,"," |
R13220 | T19922 | T19920 | arg2Of | inhibitor,"," |
R13221 | T19922 | T19921 | arg1Of | inhibitor,cellular |
R13222 | T19922 | T19923 | arg1Of | inhibitor,of |
R13223 | T19924 | T19923 | arg2Of | apoptosis,of |
R13224 | T19926 | T19927 | arg1Of | CYLD,"," |
R13225 | T19928 | T19927 | arg2Of | cylindromatosis,"," |
R13226 | T19930 | T19929 | arg2Of | IKK,; |
R13227 | T19930 | T19931 | arg1Of | IKK,"," |
R13228 | T19930 | T19934 | arg1Of | IKK,; |
R13229 | T19933 | T19931 | arg2Of | kinase,"," |
R13230 | T19933 | T19932 | arg1Of | kinase,IκB |
R13231 | T19935 | T19934 | arg2Of | IκB,; |
R13232 | T19935 | T19936 | arg1Of | IκB,"," |
R13233 | T19935 | T19940 | arg1Of | IκB,; |
R13234 | T19937 | T19936 | arg2Of | inhibitor,"," |
R13235 | T19937 | T19938 | arg1Of | inhibitor,of |
R13236 | T19939 | T19938 | arg2Of | NF-κB,of |
R13237 | T19941 | T19940 | arg2Of | IRAK,; |
R13238 | T19941 | T19942 | arg1Of | IRAK,"," |
R13239 | T19944 | T19942 | arg2Of | kinase,"," |
R13242 | T19952 | T19947 | arg2Of | gene,"," |
R13243 | T19952 | T19948 | arg1Of | gene,myeloid |
R13244 | T19952 | T19949 | arg1Of | gene,differentiation |
R13245 | T19952 | T19950 | arg1Of | gene,primary |
R13246 | T19952 | T19951 | arg1Of | gene,response |
R13247 | T19952 | T19953 | arg1Of | gene,88 |
R13248 | T19955 | T19954 | arg2Of | NEMO,; |
R13249 | T19955 | T19956 | arg1Of | NEMO,"," |
R13250 | T19959 | T19956 | arg2Of | modulator,"," |
R13251 | T19959 | T19957 | arg1Of | modulator,NF-κB |
R13252 | T19959 | T19958 | arg1Of | modulator,essential |
R13253 | T19961 | T19962 | arg1Of | NF,"," |
R13254 | T19964 | T19962 | arg2Of | factor,"," |
R13255 | T19964 | T19963 | arg1Of | factor,nuclear |
R13256 | T19966 | T19967 | arg1Of | RANK,"," |
R13257 | T19966 | T19972 | arg1Of | RANK,; |
R13258 | T19969 | T19967 | arg2Of | activator,"," |
R13259 | T19969 | T19968 | arg1Of | activator,receptor |
R13260 | T19969 | T19970 | arg1Of | activator,of |
R13261 | T19971 | T19970 | arg2Of | NF-κB,of |
R13262 | T19973 | T19972 | arg2Of | RIP1,; |
R13263 | T19973 | T19974 | arg1Of | RIP1,"," |
R13264 | T19973 | T19979 | arg1Of | RIP1,; |
R13265 | T19977 | T19974 | arg2Of | protein,"," |
R13266 | T19977 | T19975 | arg1Of | protein,receptor |
R13267 | T19977 | T19976 | arg1Of | protein,interacting |
R13268 | T19977 | T19978 | arg1Of | protein,1 |
R13269 | T19980 | T19979 | arg2Of | SIGIRR,; |
R13270 | T19980 | T19981 | arg1Of | SIGIRR,"," |
R13271 | T19982 | T19981 | arg2Of | single-immunoglobulinIL-1,"," |
R13272 | T19982 | T19983 | arg1Of | single-immunoglobulinIL-1,receptor-related |
R13273 | T19985 | T19986 | arg1Of | TIR,"," |
R13274 | T19985 | T19989 | arg1Of | TIR,; |
R13275 | T19988 | T19986 | arg2Of | receptor/IL-1R,"," |
R13276 | T19988 | T19987 | arg1Of | receptor/IL-1R,Toll-like |
R13277 | T19990 | T19989 | arg2Of | TRAF,; |
R13278 | T19990 | T19991 | arg1Of | TRAF,"," |
R13279 | T19990 | T19995 | arg1Of | TRAF,; |
R13280 | T19994 | T19991 | arg2Of | factor,"," |
R13281 | T19994 | T19992 | arg1Of | factor,TNF |
R13282 | T19994 | T19993 | arg1Of | factor,receptor-associated |
R13283 | T19996 | T19995 | arg2Of | TLR,; |
R13284 | T19996 | T19997 | arg1Of | TLR,"," |
R13285 | T19996 | T20000 | arg1Of | TLR,; |
R13286 | T19999 | T19997 | arg2Of | receptor,"," |
R13287 | T19999 | T19998 | arg1Of | receptor,Toll-like |
R13288 | T20001 | T20000 | arg2Of | TNF,; |
R13289 | T20001 | T20002 | arg1Of | TNF,"," |
R13290 | T20005 | T20002 | arg2Of | factor,"," |
R13291 | T20005 | T20003 | arg1Of | factor,tumour |
R13292 | T20005 | T20004 | arg1Of | factor,necrosis |
R14009 | T21534 | T21532 | arg1Of | signalling,Noncanonical |
R14010 | T21534 | T21533 | arg1Of | signalling,NF-κB |
R14011 | T21535 | T21536 | arg1Of | CD40,and |
R14012 | T21536 | T21538 | arg1Of | and,can |
R14013 | T21536 | T21539 | arg1Of | and,activate |
R14014 | T21537 | T21536 | arg2Of | RANK,and |
R14015 | T21539 | T21538 | arg2Of | activate,can |
R14016 | T21543 | T21539 | arg2Of | pathway,activate |
R14017 | T21543 | T21540 | arg1Of | pathway,the |
R14018 | T21543 | T21541 | arg1Of | pathway,noncanonical |
R14019 | T21543 | T21542 | arg1Of | pathway,NF-κB |
R14020 | T21543 | T21544 | arg1Of | pathway,that |
R14021 | T21543 | T21545 | arg1Of | pathway,is |
R14022 | T21543 | T21546 | arg1Of | pathway,dependent |
R14023 | T21546 | T21545 | arg2Of | dependent,is |
R14024 | T21546 | T21547 | arg1Of | dependent,on |
R14025 | T21548 | T21547 | arg2Of | NF-κB,on |
R14026 | T21548 | T21549 | arg1Of | NF-κB,inducing |
R14027 | T21552 | T21551 | arg2Of | NIK,( |
R14028 | T21553 | T21551 | arg3Of | ),( |
R14029 | T21555 | T21549 | arg2Of | levels,inducing |
R14030 | T21555 | T21550 | arg1Of | levels,kinase |
R14031 | T21555 | T21551 | arg1Of | levels,( |
R14032 | T21555 | T21554 | arg1Of | levels,expression |
R14033 | T21558 | T21556 | arg2Of | cells,In |
R14034 | T21558 | T21557 | arg1Of | cells,unstimulated |
R14035 | T21559 | T21560 | arg1Of | NIK,forms |
R14036 | T21560 | T21556 | arg1Of | forms,In |
R14037 | T21560 | T21584 | arg1Of | forms,"," |
R14038 | T21563 | T21560 | arg2Of | complex,forms |
R14039 | T21563 | T21561 | arg1Of | complex,a |
R14040 | T21563 | T21562 | arg1Of | complex,cytosolic |
R14041 | T21563 | T21564 | arg1Of | complex,with |
R14042 | T21567 | T21565 | arg1Of | ligases,the |
R14043 | T21567 | T21566 | arg1Of | ligases,ubiquitin |
R14044 | T21568 | T21569 | arg1Of | TRAF2,"," |
R14045 | T21569 | T21571 | arg1Of | ",",and |
R14046 | T21570 | T21569 | arg2Of | TRAF3,"," |
R14047 | T21571 | T21564 | arg2Of | and,with |
R14048 | T21571 | T21567 | arg1Of | and,ligases |
R14049 | T21571 | T21573 | arg1Of | and,"," |
R14050 | T21571 | T21574 | arg1Of | and,which |
R14051 | T21571 | T21575 | arg1Of | and,facilitates |
R14052 | T21572 | T21571 | arg2Of | cIAP1/2,and |
R14053 | T21577 | T21578 | arg1Of | K48-linked,polyubiquitination |
R14054 | T21577 | T21579 | arg1Of | K48-linked,and |
R14055 | T21580 | T21579 | arg2Of | proteasomal,and |
R14056 | T21581 | T21575 | arg2Of | degradation,facilitates |
R14057 | T21581 | T21576 | arg1Of | degradation,the |
R14058 | T21581 | T21577 | arg1Of | degradation,K48-linked |
R14059 | T21581 | T21580 | arg1Of | degradation,proteasomal |
R14060 | T21581 | T21582 | arg1Of | degradation,of |
R14061 | T21583 | T21582 | arg2Of | NIK,of |
R14062 | T21585 | T21560 | arg3Of | keeping,forms |
R14063 | T21587 | T21585 | arg2Of | levels,keeping |
R14064 | T21587 | T21586 | arg1Of | levels,NIK |
R14065 | T21587 | T21588 | arg1Of | levels,low |
R14066 | T21588 | T21585 | arg3Of | low,keeping |
R14067 | T21591 | T21589 | arg2Of | binding,Upon |
R14068 | T21591 | T21590 | arg1Of | binding,ligand |
R14069 | T21593 | T21594 | arg1Of | TRAF3,is |
R14070 | T21593 | T21595 | arg2Of | TRAF3,recruited |
R14071 | T21595 | T21589 | arg1Of | recruited,Upon |
R14072 | T21595 | T21592 | arg1Of | recruited,"," |
R14073 | T21595 | T21594 | arg2Of | recruited,is |
R14074 | T21595 | T21596 | arg1Of | recruited,to |
R14075 | T21598 | T21596 | arg2Of | receptor,to |
R14076 | T21598 | T21597 | arg1Of | receptor,the |
R14077 | T21598 | T21599 | arg1Of | receptor,"," |
R14078 | T21598 | T21600 | arg1Of | receptor,where |
R14079 | T21601 | T21602 | arg1Of | TRAF2,directs |
R14080 | T21602 | T21600 | arg2Of | directs,where |
R14081 | T21602 | T21608 | arg1Of | directs,"," |
R14082 | T21602 | T21609 | modOf | directs,resulting |
R14083 | T21605 | T21602 | arg2Of | polyubiquitination,directs |
R14084 | T21605 | T21603 | arg1Of | polyubiquitination,nondegradative |
R14085 | T21605 | T21604 | arg1Of | polyubiquitination,K63-linked |
R14086 | T21605 | T21606 | arg1Of | polyubiquitination,of |
R14087 | T21607 | T21606 | arg2Of | cIAP1/2,of |
R14088 | T21609 | T21610 | arg1Of | resulting,in |
R14089 | T21612 | T21610 | arg2Of | activation,in |
R14090 | T21612 | T21611 | arg1Of | activation,their |
R14091 | T21614 | T21613 | arg1Of | cIAP1/2,Subsequently |
R14092 | T21614 | T21615 | arg1Of | cIAP1/2,directs |
R14093 | T21618 | T21617 | arg1Of | polyubiquitination,K48-linked |
R14094 | T21618 | T21619 | arg1Of | polyubiquitination,to |
R14095 | T21618 | T21623 | arg1Of | polyubiquitination,than |
R14096 | T21620 | T21619 | arg2Of | TRAF3,to |
R14097 | T21623 | T21615 | arg2Of | than,directs |
R14098 | T21623 | T21616 | arg1Of | than,its |
R14099 | T21623 | T21621 | arg1Of | than,"," |
R14100 | T21623 | T21622 | arg1Of | than,rather |
R14101 | T21624 | T21623 | arg2Of | NIK,than |
R14102 | T21627 | T21625 | arg2Of | result,As |
R14103 | T21627 | T21626 | arg1Of | result,a |
R14104 | T21629 | T21630 | arg1Of | TRAF3,is |
R14105 | T21629 | T21631 | arg2Of | TRAF3,degraded |
R14106 | T21631 | T21630 | arg2Of | degraded,is |
R14107 | T21631 | T21632 | arg1Of | degraded,and |
R14108 | T21632 | T21625 | arg1Of | and,As |
R14109 | T21632 | T21628 | arg1Of | and,"," |
R14110 | T21632 | T21636 | arg1Of | and,"," |
R14111 | T21632 | T21637 | modOf | and,resulting |
R14112 | T21633 | T21634 | arg1Of | NIK,is |
R14113 | T21633 | T21635 | arg2Of | NIK,stabilised |
R14114 | T21635 | T21632 | arg2Of | stabilised,and |
R14115 | T21635 | T21634 | arg2Of | stabilised,is |
R14116 | T21637 | T21638 | arg1Of | resulting,in |
R14117 | T21641 | T21638 | arg2Of | levels,in |
R14118 | T21641 | T21639 | arg2Of | levels,increased |
R14119 | T21641 | T21640 | arg1Of | levels,NIK |
R14120 | T21641 | T21642 | arg1Of | levels,in |
R14121 | T21644 | T21642 | arg2Of | cell,in |
R14122 | T21644 | T21643 | arg1Of | cell,the |
R14123 | T21645 | T21647 | arg1Of | NIK,phosphorylates |
R14124 | T21645 | T21649 | arg1Of | NIK,activates |
R14125 | T21647 | T21648 | arg1Of | phosphorylates,and |
R14126 | T21648 | T21646 | arg1Of | and,then |
R14127 | T21649 | T21648 | arg2Of | activates,and |
R14128 | T21650 | T21647 | arg2Of | IKK1,phosphorylates |
R14129 | T21650 | T21649 | arg2Of | IKK1,activates |
R14130 | T21650 | T21651 | arg1Of | IKK1,"," |
R14131 | T21650 | T21652 | arg1Of | IKK1,which |
R14132 | T21650 | T21653 | arg1Of | IKK1,mediates |
R14133 | T21656 | T21653 | arg2Of | phosphorylation,mediates |
R14134 | T21656 | T21654 | arg1Of | phosphorylation,NF-κB |
R14135 | T21656 | T21655 | arg1Of | phosphorylation,p100 |
R14136 | T21657 | T21658 | arg1Of | This,is |
R14137 | T21657 | T21659 | arg2Of | This,followed |
R14138 | T21659 | T21658 | arg2Of | followed,is |
R14139 | T21661 | T21662 | arg1Of | K48-linked,polyubiquitination |
R14140 | T21661 | T21663 | arg1Of | K48-linked,and |
R14141 | T21665 | T21663 | arg2Of | proteasomal,and |
R14142 | T21665 | T21664 | arg1Of | proteasomal,partial |
R14143 | T21666 | T21659 | arg1Of | degradation,followed |
R14144 | T21666 | T21660 | arg2Of | degradation,by |
R14145 | T21666 | T21661 | arg1Of | degradation,K48-linked |
R14146 | T21666 | T21665 | arg1Of | degradation,proteasomal |
R14147 | T21666 | T21667 | arg1Of | degradation,of |
R14148 | T21666 | T21671 | arg1Of | degradation,"," |
R14149 | T21666 | T21672 | arg1Of | degradation,which |
R14150 | T21666 | T21673 | arg1Of | degradation,forms |
R14151 | T21668 | T21667 | arg2Of | p100,of |
R14152 | T21668 | T21669 | arg1Of | p100,to |
R14153 | T21670 | T21669 | arg2Of | p52,to |
R14154 | T21675 | T21673 | arg2Of | heterodimer,forms |
R14155 | T21675 | T21674 | arg1Of | heterodimer,a |
R14156 | T21675 | T21676 | arg1Of | heterodimer,with |
R14157 | T21675 | T21678 | modOf | heterodimer,to |
R14158 | T21677 | T21676 | arg2Of | RelB,with |
R14159 | T21679 | T21678 | arg1Of | activate,to |
R14160 | T21680 | T21679 | arg2Of | transcription,activate |
R14161 | T21681 | T21682 | arg1Of | Next,to |
R14162 | T21683 | T21682 | arg2Of | TRAF3,to |
R14163 | T21685 | T21686 | arg1Of | TRAF1,has |
R14164 | T21685 | T21688 | arg1Of | TRAF1,been |
R14165 | T21685 | T21689 | arg2Of | TRAF1,identified |
R14166 | T21689 | T21681 | arg1Of | identified,Next |
R14167 | T21689 | T21684 | arg1Of | identified,"," |
R14168 | T21689 | T21686 | arg2Of | identified,has |
R14169 | T21689 | T21687 | arg1Of | identified,also |
R14170 | T21689 | T21688 | arg2Of | identified,been |
R14171 | T21689 | T21690 | arg1Of | identified,as |
R14172 | T21689 | T21697 | arg1Of | identified,"," |
R14173 | T21689 | T21700 | arg1Of | identified,by |
R14174 | T21693 | T21690 | arg2Of | regulator,as |
R14178 | T21696 | T21694 | arg2Of | pathway,of |
R14179 | T21696 | T21695 | arg1Of | pathway,this |
R14180 | T21699 | T21698 | arg1Of | probably,most |
R14181 | T21700 | T21699 | arg1Of | by,probably |
R14182 | T21701 | T21700 | arg2Of | competing,by |
R14183 | T21701 | T21702 | arg1Of | competing,with |
R14184 | T21701 | T21718 | arg1Of | competing,; |
R14185 | T21707 | T21702 | arg2Of | cIAP,with |
R14186 | T21707 | T21703 | arg1Of | cIAP,other |
R14187 | T21707 | T21704 | arg1Of | cIAP,TNF |
R14188 | T21707 | T21705 | arg1Of | cIAP,receptor-associated |
R14189 | T21707 | T21706 | arg1Of | cIAP,factors. |
R14190 | T21707 | T21708 | arg1Of | cIAP,"," |
R14191 | T21707 | T21713 | arg1Of | cIAP,; |
R14192 | T21710 | T21708 | arg2Of | inhibitor,"," |
R14193 | T21710 | T21709 | arg1Of | inhibitor,cellular |
R14194 | T21710 | T21711 | arg1Of | inhibitor,of |
R14195 | T21712 | T21711 | arg2Of | apoptosis,of |
R14196 | T21714 | T21713 | arg2Of | IKK,; |
R14197 | T21714 | T21715 | arg1Of | IKK,"," |
R14198 | T21717 | T21715 | arg2Of | kinase,"," |
R14199 | T21717 | T21716 | arg1Of | kinase,IκB |
R14200 | T21719 | T21689 | arg3Of | NF,identified |
R14201 | T21719 | T21720 | arg1Of | NF,"," |
R14202 | T21719 | T21723 | arg1Of | NF,; |
R14203 | T21722 | T21720 | arg2Of | factor,"," |
R14204 | T21722 | T21721 | arg1Of | factor,nuclear |
R14205 | T21724 | T21723 | arg2Of | RANK,; |
R14206 | T21724 | T21725 | arg1Of | RANK,"," |
R14207 | T21724 | T21730 | arg1Of | RANK,; |
R14208 | T21727 | T21725 | arg2Of | activator,"," |
R14209 | T21727 | T21726 | arg1Of | activator,receptor |
R14210 | T21727 | T21728 | arg1Of | activator,of |
R14211 | T21729 | T21728 | arg2Of | NF-κB,of |
R14212 | T21731 | T21730 | arg2Of | TRAF,; |
R14213 | T21731 | T21732 | arg1Of | TRAF,"," |
R14214 | T21731 | T21736 | arg1Of | TRAF,; |
R14215 | T21735 | T21732 | arg2Of | factor,"," |
R14216 | T21735 | T21733 | arg1Of | factor,TNF |
R14217 | T21735 | T21734 | arg1Of | factor,receptor-associated |
R14218 | T21737 | T21736 | arg2Of | TNF,; |
R14219 | T21737 | T21738 | arg1Of | TNF,"," |
R14220 | T21741 | T21738 | arg2Of | factor,"," |
R14221 | T21741 | T21739 | arg1Of | factor,tumour |
R14222 | T21741 | T21740 | arg1Of | factor,necrosis |
R233 | T375 | T374 | arg1Of | arthritis,Rheumatoid |
R234 | T375 | T376 | arg1Of | arthritis,( |
R235 | T375 | T379 | arg1Of | arthritis,is |
R236 | T375 | T386 | arg1Of | arthritis,affecting |
R237 | T377 | T376 | arg2Of | RA,( |
R238 | T378 | T376 | arg3Of | ),( |
R239 | T379 | T385 | arg1Of | is,"," |
R240 | T379 | T386 | modOf | is,affecting |
R241 | T382 | T381 | arg1Of | common,most |
R242 | T384 | T379 | arg2Of | arthritis,is |
R12537 | T18979 | T18977 | arg2Of | number,given |
R12538 | T18979 | T18978 | arg1Of | number,the |
R12539 | T18979 | T18980 | arg1Of | number,of |
R12540 | T18979 | T18982 | arg1Of | number,in |
R12541 | T18981 | T18980 | arg2Of | miRNAs,of |
R12542 | T18983 | T18984 | arg1Of | humans,and |
R12543 | T18984 | T18982 | arg2Of | and,in |
R12544 | T18987 | T18984 | arg2Of | mRNAs,and |
R12545 | T18987 | T18985 | arg1Of | mRNAs,the |
R12546 | T18987 | T18986 | arg1Of | mRNAs,multiple |
UBERON-AE
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T17435 | 31175-31180 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T17434 | 31610-31616 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissue |
T17433 | 31134-31140 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissue |
T15483 | 27521-27532 | http://purl.obolibrary.org/obo/UBERON_2000106 | denotes | extensively |
T12641 | 24168-24174 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissue |
T12640 | 23983-23988 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
T9641 | 20980-20985 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | serum |
T9640 | 21249-21255 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissue |
T9639 | 20526-20532 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissue |
T9638 | 19732-19742 | http://purl.obolibrary.org/obo/UBERON_0000483 | denotes | epithelium |
T9637 | 19721-19742 | http://purl.obolibrary.org/obo/UBERON_0001277 | denotes | intestinal epithelium |
T9636 | 19612-19633 | http://purl.obolibrary.org/obo/UBERON_0001277 | denotes | intestinal epithelial |
T9635 | 19490-19511 | http://purl.obolibrary.org/obo/UBERON_0001277 | denotes | intestinal epithelial |
T9634 | 19721-19731 | http://purl.obolibrary.org/obo/UBERON_0000160 | denotes | intestinal |
T9633 | 19612-19622 | http://purl.obolibrary.org/obo/UBERON_0000160 | denotes | intestinal |
T9632 | 19490-19500 | http://purl.obolibrary.org/obo/UBERON_0000160 | denotes | intestinal |
T4236 | 13004-13009 | http://purl.obolibrary.org/obo/UBERON_0000062 | denotes | organ |
T1754 | 6775-6779 | http://purl.obolibrary.org/obo/UBERON_3000101 | denotes | hyal |
T1753 | 6507-6521 | http://purl.obolibrary.org/obo/UBERON_0001090 | denotes | synovial fluid |
T1752 | 6904-6910 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissue |
T1751 | 6172-6178 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissue |
T1750 | 5601-5608 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
T1749 | 5433-5440 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissues |
T1748 | 5086-5091 | http://purl.obolibrary.org/obo/UBERON_0000062 | denotes | organ |
T1747 | 3114-3121 | http://purl.obolibrary.org/obo/UBERON_0012131 | denotes | central |
T323 | 2195-2201 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissue |
T322 | 1343-1349 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissue |
T321 | 1054-1067 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T21763 | 15150-15158 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
T21762 | 15150-15158 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
T21761 | 15150-15158 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
T21760 | 15150-15158 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
T21759 | 15080-15098 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | activator of NF-κB |
T21758 | 15028-15031 | http://purl.obolibrary.org/obo/GO_0008384 | denotes | IKK |
T21757 | 15017-15026 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T21756 | 15017-15026 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T21755 | 14995-15003 | http://purl.obolibrary.org/obo/GO_0007349 | denotes | cellular |
T21754 | 14816-14829 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
T21753 | 14649-14664 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T21752 | 14740-14751 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degradation |
T21751 | 14179-14190 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degradation |
T21750 | 14579-14582 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T21749 | 14555-14558 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T21748 | 14513-14516 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T21747 | 14473-14476 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T21746 | 14207-14210 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T21745 | 14194-14197 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T21744 | 14028-14031 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T21743 | 13982-13985 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T21742 | 13868-13878 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T20034 | 10260-10269 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T20033 | 10260-10269 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T20032 | 10238-10246 | http://purl.obolibrary.org/obo/GO_0007349 | denotes | cellular |
T20031 | 10316-10334 | http://purl.obolibrary.org/obo/GO_0007252 | denotes | inhibitor of NF-κB |
T20030 | 10212-10230 | http://purl.obolibrary.org/obo/GO_0007252 | denotes | inhibitor of NF-κB |
T20029 | 10316-10334 | http://purl.obolibrary.org/obo/GO_0032088 | denotes | inhibitor of NF-κB |
T20028 | 10212-10230 | http://purl.obolibrary.org/obo/GO_0032088 | denotes | inhibitor of NF-κB |
T20027 | 10162-10172 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
T20026 | 9551-9575 | http://purl.obolibrary.org/obo/GO_0004843 | denotes | deubiquitinating enzymes |
T20025 | 10492-10510 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | activator of NF-κB |
T20024 | 10176-10192 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T20023 | 9589-9605 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T20022 | 9471-9487 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T20021 | 9430-9445 | http://purl.obolibrary.org/obo/GO_0016874 | denotes | ligase activity |
T20020 | 9420-9445 | http://purl.obolibrary.org/obo/GO_0034450 | denotes | ubiquitin ligase activity |
T20019 | 9420-9445 | http://purl.obolibrary.org/obo/GO_1904667 | denotes | ubiquitin ligase activity |
T20018 | 9420-9445 | http://purl.obolibrary.org/obo/GO_0061630 | denotes | ubiquitin ligase activity |
T20017 | 9420-9445 | http://purl.obolibrary.org/obo/GO_1904668 | denotes | ubiquitin ligase activity |
T20016 | 9420-9445 | http://purl.obolibrary.org/obo/GO_1990757 | denotes | ubiquitin ligase activity |
T20015 | 9420-9445 | http://purl.obolibrary.org/obo/GO_1904666 | denotes | ubiquitin ligase activity |
T20014 | 9420-9445 | http://purl.obolibrary.org/obo/GO_0050372 | denotes | ubiquitin ligase activity |
T20013 | 9420-9445 | http://purl.obolibrary.org/obo/GO_0004842 | denotes | ubiquitin ligase activity |
T20012 | 9383-9398 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
T20011 | 9258-9269 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degradation |
T20010 | 8757-8762 | http://purl.obolibrary.org/obo/GO_0016265 | denotes | death |
T20009 | 9891-9901 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T20008 | 9822-9832 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T20007 | 9628-9638 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T20006 | 8556-8566 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T20042 | 10708-10716 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
T20041 | 10708-10716 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
T20040 | 10708-10716 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
T20039 | 10708-10716 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
T20038 | 10617-10628 | http://purl.obolibrary.org/obo/GO_0004896 | denotes | receptor/IL |
T20037 | 10626-10631 | http://purl.obolibrary.org/obo/GO_0004908 | denotes | IL-1R |
T20036 | 10342-10347 | http://purl.obolibrary.org/obo/GO_0004908 | denotes | IL-1R |
T20035 | 10294-10297 | http://purl.obolibrary.org/obo/GO_0008384 | denotes | IKK |
T19043 | 33514-33530 | http://purl.obolibrary.org/obo/GO_0038061 | denotes | NF-κB signalling |
T19042 | 33520-33530 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T19041 | 33427-33434 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signals |
T19040 | 33134-33144 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
T19039 | 32972-32988 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T19038 | 32843-32856 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
T17987 | 31812-31824 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T17986 | 30425-30437 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T17985 | 30404-30420 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
T17984 | 31859-31870 | http://purl.obolibrary.org/obo/GO_0032502 | denotes | development |
T17983 | 30369-30392 | http://purl.obolibrary.org/obo/GO_0032502 | denotes | developmental processes |
T17982 | 30356-30392 | http://purl.obolibrary.org/obo/GO_0048869 | denotes | cellular and developmental processes |
T17981 | 30356-30364 | http://purl.obolibrary.org/obo/GO_0007349 | denotes | cellular |
T17980 | 30273-30288 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
T18003 | 32531-32568 | http://purl.obolibrary.org/obo/GO_1904465 | denotes | secretion of matrix metalloproteinase |
T18002 | 32531-32568 | http://purl.obolibrary.org/obo/GO_1990773 | denotes | secretion of matrix metalloproteinase |
T18001 | 32531-32568 | http://purl.obolibrary.org/obo/GO_1904466 | denotes | secretion of matrix metalloproteinase |
T18000 | 32531-32568 | http://purl.obolibrary.org/obo/GO_1904464 | denotes | secretion of matrix metalloproteinase |
T17999 | 32531-32540 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
T17998 | 32785-32797 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
T17997 | 31717-31729 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
T17996 | 31680-31694 | http://purl.obolibrary.org/obo/GO_0032640 | denotes | TNF production |
T17995 | 30979-30995 | http://purl.obolibrary.org/obo/GO_0038061 | denotes | NF-κB signalling |
T17994 | 30816-30832 | http://purl.obolibrary.org/obo/GO_0038061 | denotes | NF-κB signalling |
T17993 | 30985-30995 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T17992 | 30822-30832 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T17991 | 30642-30652 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T17990 | 30557-30568 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degradation |
T17989 | 30552-30568 | http://purl.obolibrary.org/obo/GO_0006402 | denotes | mRNA degradation |
T17988 | 32242-32264 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory responses |
T16690 | 29231-29249 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signalling pathway |
T16689 | 29207-29241 | http://purl.obolibrary.org/obo/GO_1901224 | denotes | activation of the NF-κB signalling |
T16688 | 29544-29561 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF- κB activation |
T16687 | 29312-29328 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T16686 | 29104-29120 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T16685 | 29672-29682 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T16684 | 29231-29241 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T16683 | 28921-28931 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T16682 | 28808-28823 | http://purl.obolibrary.org/obo/GO_0016874 | denotes | ligase activity |
T16681 | 28798-28823 | http://purl.obolibrary.org/obo/GO_0034450 | denotes | ubiquitin ligase activity |
T16680 | 28798-28823 | http://purl.obolibrary.org/obo/GO_1904667 | denotes | ubiquitin ligase activity |
T16679 | 28798-28823 | http://purl.obolibrary.org/obo/GO_0061630 | denotes | ubiquitin ligase activity |
T16678 | 28798-28823 | http://purl.obolibrary.org/obo/GO_1904668 | denotes | ubiquitin ligase activity |
T16677 | 28798-28823 | http://purl.obolibrary.org/obo/GO_1990757 | denotes | ubiquitin ligase activity |
T16676 | 28798-28823 | http://purl.obolibrary.org/obo/GO_1904666 | denotes | ubiquitin ligase activity |
T16675 | 28798-28823 | http://purl.obolibrary.org/obo/GO_0050372 | denotes | ubiquitin ligase activity |
T16674 | 28798-28823 | http://purl.obolibrary.org/obo/GO_0004842 | denotes | ubiquitin ligase activity |
T14593 | 27198-27208 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
T14592 | 26876-26892 | http://purl.obolibrary.org/obo/GO_0016579 | denotes | deubiquitination |
T14591 | 26439-26465 | http://purl.obolibrary.org/obo/GO_0030316 | denotes | osteoclast differentiation |
T14590 | 25964-25980 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T14589 | 27154-27164 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T14588 | 26338-26348 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T14587 | 26186-26196 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T14586 | 26123-26133 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T14585 | 25777-25787 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T14584 | 25644-25654 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T14583 | 25588-25611 | http://purl.obolibrary.org/obo/GO_0004843 | denotes | deubiquitinating enzyme |
T14582 | 25518-25533 | http://purl.obolibrary.org/obo/GO_0007283 | denotes | spermatogenesis |
T14581 | 25494-25516 | http://purl.obolibrary.org/obo/GO_0051726 | denotes | cell cycle progression |
T14580 | 25494-25516 | http://purl.obolibrary.org/obo/GO_0007050 | denotes | cell cycle progression |
T14579 | 25494-25504 | http://purl.obolibrary.org/obo/GO_0007049 | denotes | cell cycle |
T14578 | 25478-25490 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T13131 | 24308-24320 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
T13130 | 24289-24299 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T13129 | 24283-24299 | http://purl.obolibrary.org/obo/GO_0038061 | denotes | NF-κB signalling |
T13128 | 24269-24299 | http://purl.obolibrary.org/obo/GO_1901222 | denotes | regulation of NF-κB signalling |
T13127 | 23989-23998 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T13126 | 23895-23904 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T13125 | 23989-23998 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T13124 | 23895-23904 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T13123 | 24269-24279 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
T13122 | 23425-23435 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
T13121 | 23439-23455 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T13120 | 23060-23076 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T13119 | 23052-23076 | http://purl.obolibrary.org/obo/GO_1903721 | denotes | inhibit NF-κB activation |
T13118 | 23052-23065 | http://purl.obolibrary.org/obo/GO_0007252 | denotes | inhibit NF-κB |
T13117 | 22878-22897 | http://purl.obolibrary.org/obo/GO_0007252 | denotes | inhibitors of NF-κB |
T13116 | 23052-23065 | http://purl.obolibrary.org/obo/GO_0032088 | denotes | inhibit NF-κB |
T13115 | 22878-22897 | http://purl.obolibrary.org/obo/GO_0032088 | denotes | inhibitors of NF-κB |
T10682 | 22559-22572 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
T10681 | 21671-21682 | http://purl.obolibrary.org/obo/GO_0032502 | denotes | development |
T10680 | 20914-20923 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
T10679 | 20654-20664 | http://purl.obolibrary.org/obo/GO_0042056 | denotes | attractant |
T10678 | 20197-20207 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
T10677 | 19586-19602 | http://purl.obolibrary.org/obo/GO_0002524 | denotes | hypersensitivity |
T10676 | 19612-19639 | http://purl.obolibrary.org/obo/GO_0060576 | denotes | intestinal epithelial cells |
T10675 | 19490-19517 | http://purl.obolibrary.org/obo/GO_0060576 | denotes | intestinal epithelial cells |
T10674 | 19612-19639 | http://purl.obolibrary.org/obo/GO_0060575 | denotes | intestinal epithelial cells |
T10673 | 19490-19517 | http://purl.obolibrary.org/obo/GO_0060575 | denotes | intestinal epithelial cells |
T10672 | 19612-19639 | http://purl.obolibrary.org/obo/GO_0060574 | denotes | intestinal epithelial cells |
T10671 | 19490-19517 | http://purl.obolibrary.org/obo/GO_0060574 | denotes | intestinal epithelial cells |
T10670 | 19612-19639 | http://purl.obolibrary.org/obo/GO_0061582 | denotes | intestinal epithelial cells |
T10669 | 19490-19517 | http://purl.obolibrary.org/obo/GO_0061582 | denotes | intestinal epithelial cells |
T10668 | 20342-20354 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T10667 | 19178-19190 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T10666 | 19655-19664 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T10665 | 19373-19382 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T10664 | 18998-19007 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T10663 | 19655-19664 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T10662 | 19373-19382 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T10661 | 18998-19007 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T10660 | 20793-20809 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T10659 | 18946-18962 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T10658 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0061667 | denotes | E3 |
T10657 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0061666 | denotes | E3 |
T10656 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0061665 | denotes | E3 |
T10655 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0061664 | denotes | E3 |
T10654 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0061663 | denotes | E3 |
T10653 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0061662 | denotes | E3 |
T10652 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0061661 | denotes | E3 |
T10651 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0061660 | denotes | E3 |
T10650 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0061659 | denotes | E3 |
T10649 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0061630 | denotes | E3 |
T10648 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0061658 | denotes | E2 |
T10647 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0061657 | denotes | E2 |
T10646 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0061656 | denotes | E2 |
T10645 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0061655 | denotes | E2 |
T10644 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0061654 | denotes | E2 |
T10643 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0061653 | denotes | E2 |
T10642 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0061652 | denotes | E2 |
T10641 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0061651 | denotes | E2 |
T10640 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0061650 | denotes | E2 |
T10639 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0061631 | denotes | E2 |
T10638 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0019787 | denotes | E3 |
T10637 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0019787 | denotes | E2 |
T10636 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0004842 | denotes | E3 |
T10635 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0004842 | denotes | E2 |
T10634 | 22163-22170 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signals |
T10633 | 20217-20227 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T10632 | 19086-19096 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T10631 | 18717-18727 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T10630 | 18352-18362 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T10629 | 20211-20227 | http://purl.obolibrary.org/obo/GO_0038061 | denotes | NF-κB signalling |
T10628 | 18711-18727 | http://purl.obolibrary.org/obo/GO_0038061 | denotes | NF-κB signalling |
T10627 | 18346-18362 | http://purl.obolibrary.org/obo/GO_0038061 | denotes | NF-κB signalling |
T10626 | 18850-18868 | http://purl.obolibrary.org/obo/GO_0007252 | denotes | inhibitor of NF-κB |
T10625 | 18294-18307 | http://purl.obolibrary.org/obo/GO_0007252 | denotes | inhibit NF-κB |
T10624 | 18850-18868 | http://purl.obolibrary.org/obo/GO_0032088 | denotes | inhibitor of NF-κB |
T10623 | 18294-18307 | http://purl.obolibrary.org/obo/GO_0032088 | denotes | inhibit NF-κB |
T10622 | 20831-20846 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
T10621 | 18054-18069 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
T8748 | 16053-16069 | http://purl.obolibrary.org/obo/GO_0038061 | denotes | NF-κB signalling |
T8747 | 17705-17715 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
T8746 | 17218-17228 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
T8745 | 16833-16843 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
T8744 | 16035-16045 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
T8743 | 16007-16025 | http://purl.obolibrary.org/obo/GO_0009987 | denotes | cellular processes |
T8742 | 16007-16015 | http://purl.obolibrary.org/obo/GO_0007349 | denotes | cellular |
T8757 | 17680-17683 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T8756 | 17462-17473 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degradation |
T8755 | 16287-16299 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T8754 | 16147-16168 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
T8753 | 16059-16077 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signalling pathway |
T8752 | 17566-17576 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T8751 | 16446-16456 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T8750 | 16059-16069 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T8749 | 16440-16456 | http://purl.obolibrary.org/obo/GO_0038061 | denotes | NF-κB signalling |
T5606 | 15780-15795 | http://purl.obolibrary.org/obo/GO_0032675 | denotes | IL-6 production |
T5605 | 15780-15795 | http://purl.obolibrary.org/obo/GO_0032635 | denotes | IL-6 production |
T5604 | 15761-15764 | http://purl.obolibrary.org/obo/GO_0004705 | denotes | JNK |
T5603 | 15469-15480 | http://purl.obolibrary.org/obo/GO_0006508 | denotes | proteolysis |
T5602 | 15278-15307 | http://purl.obolibrary.org/obo/GO_1901222 | denotes | noncanonical NF-κB signalling |
T5601 | 15278-15307 | http://purl.obolibrary.org/obo/GO_1901223 | denotes | noncanonical NF-κB signalling |
T5600 | 13777-13780 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T5599 | 13725-13728 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T5598 | 13426-13429 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T5597 | 13330-13333 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T5596 | 13185-13188 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T5595 | 13179-13182 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T5594 | 13004-13021 | http://purl.obolibrary.org/obo/GO_0048513 | denotes | organ development |
T5593 | 13010-13021 | http://purl.obolibrary.org/obo/GO_0032502 | denotes | development |
T5592 | 12972-12983 | http://purl.obolibrary.org/obo/GO_0032502 | denotes | development |
T5591 | 12967-12983 | http://purl.obolibrary.org/obo/GO_0048468 | denotes | cell development |
T5590 | 12965-12983 | http://purl.obolibrary.org/obo/GO_0002329 | denotes | B-cell development |
T5589 | 12965-12983 | http://purl.obolibrary.org/obo/GO_0002328 | denotes | B-cell development |
T5588 | 12385-12390 | http://purl.obolibrary.org/obo/GO_0004908 | denotes | IL-1R |
T5587 | 12065-12078 | http://purl.obolibrary.org/obo/GO_0004908 | denotes | IL-1 receptor |
T5586 | 15278-15307 | http://purl.obolibrary.org/obo/GO_1901224 | denotes | noncanonical NF-κB signalling |
T5585 | 11684-11710 | http://purl.obolibrary.org/obo/GO_1901224 | denotes | activated NF-κB signalling |
T5584 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0061658 | denotes | E2 |
T5583 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0061657 | denotes | E2 |
T5582 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0061656 | denotes | E2 |
T5581 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0061655 | denotes | E2 |
T5580 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0061654 | denotes | E2 |
T5579 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0061653 | denotes | E2 |
T5578 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0061652 | denotes | E2 |
T5577 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0061651 | denotes | E2 |
T5576 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0061650 | denotes | E2 |
T5575 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0061631 | denotes | E2 |
T5574 | 11859-11872 | http://purl.obolibrary.org/obo/GO_0000209 | denotes | polyubiquitin |
T5573 | 11776-11789 | http://purl.obolibrary.org/obo/GO_0000209 | denotes | polyubiquitin |
T5572 | 11638-11651 | http://purl.obolibrary.org/obo/GO_0000209 | denotes | polyubiquitin |
T5571 | 11381-11394 | http://purl.obolibrary.org/obo/GO_0000209 | denotes | polyubiquitin |
T5570 | 11242-11255 | http://purl.obolibrary.org/obo/GO_0000209 | denotes | polyubiquitin |
T5569 | 11123-11132 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
T5568 | 11123-11132 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
T5567 | 11101-11109 | http://purl.obolibrary.org/obo/GO_0007349 | denotes | cellular |
T5566 | 11589-11591 | http://purl.obolibrary.org/obo/GO_0061667 | denotes | E3 |
T5565 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0061667 | denotes | E3 |
T5564 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0061667 | denotes | E3 |
T5563 | 11589-11591 | http://purl.obolibrary.org/obo/GO_0061666 | denotes | E3 |
T5562 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0061666 | denotes | E3 |
T5561 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0061666 | denotes | E3 |
T5560 | 11589-11591 | http://purl.obolibrary.org/obo/GO_0061665 | denotes | E3 |
T5559 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0061665 | denotes | E3 |
T5558 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0061665 | denotes | E3 |
T5557 | 11589-11591 | http://purl.obolibrary.org/obo/GO_0061664 | denotes | E3 |
T5556 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0061664 | denotes | E3 |
T5555 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0061664 | denotes | E3 |
T5554 | 11589-11591 | http://purl.obolibrary.org/obo/GO_0061663 | denotes | E3 |
T5553 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0061663 | denotes | E3 |
T5552 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0061663 | denotes | E3 |
T5551 | 11589-11591 | http://purl.obolibrary.org/obo/GO_0061662 | denotes | E3 |
T5550 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0061662 | denotes | E3 |
T5549 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0061662 | denotes | E3 |
T5548 | 11589-11591 | http://purl.obolibrary.org/obo/GO_0061661 | denotes | E3 |
T5547 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0061661 | denotes | E3 |
T5546 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0061661 | denotes | E3 |
T5545 | 11589-11591 | http://purl.obolibrary.org/obo/GO_0061660 | denotes | E3 |
T5544 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0061660 | denotes | E3 |
T5543 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0061660 | denotes | E3 |
T5542 | 11589-11591 | http://purl.obolibrary.org/obo/GO_0061659 | denotes | E3 |
T5541 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0061659 | denotes | E3 |
T5540 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0061659 | denotes | E3 |
T5539 | 11589-11591 | http://purl.obolibrary.org/obo/GO_0061630 | denotes | E3 |
T5538 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0061630 | denotes | E3 |
T5537 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0061630 | denotes | E3 |
T5536 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0019787 | denotes | E2 |
T5535 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0019787 | denotes | E3 |
T5534 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0019787 | denotes | E3 |
T5533 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0004842 | denotes | E2 |
T5532 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0004842 | denotes | E3 |
T5531 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0004842 | denotes | E3 |
T5530 | 10867-10872 | http://purl.obolibrary.org/obo/GO_0016265 | denotes | death |
T5529 | 15825-15844 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | activation of NF-κB |
T5528 | 11684-11699 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | activated NF-κB |
T5527 | 8507-8523 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T5526 | 13457-13486 | http://purl.obolibrary.org/obo/GO_1903009 | denotes | degradation by the proteasome |
T5525 | 8180-8209 | http://purl.obolibrary.org/obo/GO_1903009 | denotes | degradation by the proteasome |
T5524 | 13751-13762 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degradation |
T5523 | 13678-13689 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degradation |
T5522 | 13457-13468 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degradation |
T5521 | 8180-8191 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degradation |
T5520 | 13803-13818 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T5519 | 13137-13152 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T5518 | 8092-8107 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T5517 | 12606-12609 | http://purl.obolibrary.org/obo/GO_0008384 | denotes | IKK |
T5516 | 11459-11462 | http://purl.obolibrary.org/obo/GO_0008384 | denotes | IKK |
T5515 | 8220-8223 | http://purl.obolibrary.org/obo/GO_0008384 | denotes | IKK |
T5514 | 8063-8066 | http://purl.obolibrary.org/obo/GO_0008384 | denotes | IKK |
T5513 | 7917-7926 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
T5512 | 15297-15316 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signalling pathways |
T5511 | 10755-10774 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signalling pathways |
T5510 | 7542-7561 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signalling pathways |
T5509 | 15895-15905 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T5508 | 15297-15307 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T5507 | 11933-11943 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T5506 | 11700-11710 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T5505 | 10755-10765 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T5504 | 7860-7870 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T5503 | 7542-7552 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T5502 | 15278-15307 | http://purl.obolibrary.org/obo/GO_0038061 | denotes | noncanonical NF-κB signalling |
T5501 | 11694-11710 | http://purl.obolibrary.org/obo/GO_0038061 | denotes | NF-κB signalling |
T5500 | 10749-10765 | http://purl.obolibrary.org/obo/GO_0038061 | denotes | NF-κB signalling |
T5499 | 7854-7870 | http://purl.obolibrary.org/obo/GO_0038061 | denotes | NF-κB signalling |
T5498 | 7536-7552 | http://purl.obolibrary.org/obo/GO_0038061 | denotes | NF-κB signalling |
T5497 | 7405-7420 | http://purl.obolibrary.org/obo/GO_2000144 | denotes | transactivation |
T5496 | 7344-7363 | http://purl.obolibrary.org/obo/GO_0007252 | denotes | inhibitors of NF-κB |
T5495 | 7130-7148 | http://purl.obolibrary.org/obo/GO_0007252 | denotes | inhibitor of NF-κB |
T5494 | 7344-7363 | http://purl.obolibrary.org/obo/GO_0032088 | denotes | inhibitors of NF-κB |
T5493 | 7130-7148 | http://purl.obolibrary.org/obo/GO_0032088 | denotes | inhibitor of NF-κB |
T5492 | 7043-7054 | http://purl.obolibrary.org/obo/GO_0051235 | denotes | sequestered |
T5491 | 7030-7071 | http://purl.obolibrary.org/obo/GO_0051220 | denotes | proteins are sequestered in the cytoplasm |
T5490 | 7030-7054 | http://purl.obolibrary.org/obo/GO_0050821 | denotes | proteins are sequestered |
T5489 | 7030-7054 | http://purl.obolibrary.org/obo/GO_0045185 | denotes | proteins are sequestered |
T2513 | 6963-6978 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
T2512 | 5851-5863 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
T2511 | 5092-5101 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
T2510 | 4812-4827 | http://purl.obolibrary.org/obo/GO_0001775 | denotes | cell activating |
T2509 | 4810-4827 | http://purl.obolibrary.org/obo/GO_0042113 | denotes | B-cell activating |
T2508 | 4810-4827 | http://purl.obolibrary.org/obo/GO_0050864 | denotes | B-cell activating |
T2507 | 4384-4393 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
T2506 | 4355-4379 | http://purl.obolibrary.org/obo/GO_0048144 | denotes | fibroblast proliferation |
T2505 | 5770-5780 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T2504 | 5034-5044 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T2503 | 3800-3810 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T2502 | 3794-3810 | http://purl.obolibrary.org/obo/GO_0038061 | denotes | NF-κB signalling |
T2501 | 6929-6945 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T2500 | 4325-4341 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T2499 | 3644-3660 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T2498 | 3532-3548 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T2497 | 3484-3503 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | activators of NF-κB |
T2496 | 3235-3249 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | activate NF-κB |
T2495 | 6586-6598 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T2494 | 5812-5824 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T2493 | 5531-5543 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T2492 | 5296-5308 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T2491 | 5122-5134 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T798 | 3032-3044 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
T797 | 2918-2928 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T796 | 2912-2928 | http://purl.obolibrary.org/obo/GO_0038061 | denotes | NF-κB signalling |
T795 | 2713-2723 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
T794 | 1942-1963 | http://purl.obolibrary.org/obo/GO_0051001 | denotes | nitric oxide synthase |
T793 | 1942-1963 | http://purl.obolibrary.org/obo/GO_0050999 | denotes | nitric oxide synthase |
T792 | 1942-1963 | http://purl.obolibrary.org/obo/GO_0051000 | denotes | nitric oxide synthase |
T791 | 1942-1963 | http://purl.obolibrary.org/obo/GO_0004517 | denotes | nitric oxide synthase |
T790 | 1907-1916 | http://purl.obolibrary.org/obo/GO_0016701 | denotes | oxygenase |
T789 | 2313-2324 | http://purl.obolibrary.org/obo/GO_0032502 | denotes | development |
T788 | 1564-1575 | http://purl.obolibrary.org/obo/GO_0032502 | denotes | development |
T787 | 2554-2569 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
T786 | 1524-1539 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
T785 | 3009-3025 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T784 | 2385-2401 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T783 | 2116-2132 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T782 | 2075-2094 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | activators of NF-κB |
T781 | 1494-1513 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | activation of NF-κB |
T780 | 1369-1377 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degrades |
T779 | 1323-1332 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
T778 | 1265-1285 | http://purl.obolibrary.org/obo/GO_0008283 | denotes | cells. Proliferation |
T777 | 868-880 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T15772 | 27757-27769 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T15771 | 27731-27741 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T15770 | 27580-27590 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T15769 | 27717-27722 | http://purl.obolibrary.org/obo/GO_0004908 | denotes | IL-1R |
T15768 | 27566-27571 | http://purl.obolibrary.org/obo/GO_0004908 | denotes | IL-1R |
T15767 | 27494-27499 | http://purl.obolibrary.org/obo/GO_0004908 | denotes | IL-1R |
T15766 | 27410-27423 | http://purl.obolibrary.org/obo/GO_0004908 | denotes | IL-1 receptor |
T15765 | 27358-27371 | http://purl.obolibrary.org/obo/GO_0004908 | denotes | IL-1 receptor |
T2490 | 3140-3152 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T100 | 141-151 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
T101 | 87-100 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
T102 | 155-167 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T103 | 369-385 | http://purl.obolibrary.org/obo/GO_0038061 | denotes | NF-κB signalling |
T104 | 580-596 | http://purl.obolibrary.org/obo/GO_0038061 | denotes | NF-κB signalling |
T105 | 375-385 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T106 | 586-596 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
T107 | 635-647 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
T99 | 9-19 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
GO-MF
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T21775 | 15028-15031 | http://purl.obolibrary.org/obo/GO_0008384 | denotes | IKK |
T21774 | 14235-14242 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T21773 | 14228-14234 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | ligand |
T21772 | 14067-14076 | http://purl.obolibrary.org/obo/GO_0031386 | denotes | ubiquitin |
T21771 | 14579-14582 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T21770 | 14555-14558 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T21769 | 14513-14516 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T21768 | 14473-14476 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T21767 | 14207-14210 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T21766 | 14194-14197 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T21765 | 14028-14031 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T21764 | 13982-13985 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T20062 | 10617-10628 | http://purl.obolibrary.org/obo/GO_0004896 | denotes | receptor/IL |
T20061 | 10626-10631 | http://purl.obolibrary.org/obo/GO_0004908 | denotes | IL-1R |
T20060 | 10342-10347 | http://purl.obolibrary.org/obo/GO_0004908 | denotes | IL-1R |
T20059 | 10294-10297 | http://purl.obolibrary.org/obo/GO_0008384 | denotes | IKK |
T20058 | 10001-10017 | http://purl.obolibrary.org/obo/GO_0035662 | denotes | TLR4 for binding |
T20057 | 9717-9734 | http://purl.obolibrary.org/obo/GO_0043130 | denotes | ubiquitin-binding |
T20056 | 9551-9575 | http://purl.obolibrary.org/obo/GO_0004843 | denotes | deubiquitinating enzymes |
T20055 | 9430-9445 | http://purl.obolibrary.org/obo/GO_0016874 | denotes | ligase activity |
T20054 | 9420-9445 | http://purl.obolibrary.org/obo/GO_0034450 | denotes | ubiquitin ligase activity |
T20053 | 9420-9445 | http://purl.obolibrary.org/obo/GO_0061630 | denotes | ubiquitin ligase activity |
T20052 | 9420-9445 | http://purl.obolibrary.org/obo/GO_1990757 | denotes | ubiquitin ligase activity |
T20051 | 9420-9445 | http://purl.obolibrary.org/obo/GO_0050372 | denotes | ubiquitin ligase activity |
T20050 | 9420-9445 | http://purl.obolibrary.org/obo/GO_0004842 | denotes | ubiquitin ligase activity |
T20049 | 9717-9726 | http://purl.obolibrary.org/obo/GO_0031386 | denotes | ubiquitin |
T20048 | 9420-9429 | http://purl.obolibrary.org/obo/GO_0031386 | denotes | ubiquitin |
T20047 | 8886-8895 | http://purl.obolibrary.org/obo/GO_0031386 | denotes | ubiquitin |
T20046 | 10204-10211 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T20045 | 10010-10017 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T20044 | 9727-9734 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T20043 | 8592-8598 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | Ligand |
T18006 | 32575-32579 | http://purl.obolibrary.org/obo/GO_0005138 | denotes | IL-6 |
T18005 | 32569-32577 | http://purl.obolibrary.org/obo/GO_0005149 | denotes | 1 and IL |
T18004 | 31263-31268 | http://purl.obolibrary.org/obo/GO_0030367 | denotes | IL-17 |
T16699 | 29639-29662 | http://purl.obolibrary.org/obo/GO_0005102 | denotes | binding to the receptor |
T16698 | 29639-29646 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T16697 | 28808-28823 | http://purl.obolibrary.org/obo/GO_0016874 | denotes | ligase activity |
T16696 | 28798-28823 | http://purl.obolibrary.org/obo/GO_0034450 | denotes | ubiquitin ligase activity |
T16695 | 28798-28823 | http://purl.obolibrary.org/obo/GO_0061630 | denotes | ubiquitin ligase activity |
T16694 | 28798-28823 | http://purl.obolibrary.org/obo/GO_1990757 | denotes | ubiquitin ligase activity |
T16693 | 28798-28823 | http://purl.obolibrary.org/obo/GO_0050372 | denotes | ubiquitin ligase activity |
T16692 | 28798-28823 | http://purl.obolibrary.org/obo/GO_0004842 | denotes | ubiquitin ligase activity |
T16691 | 28798-28807 | http://purl.obolibrary.org/obo/GO_0031386 | denotes | ubiquitin |
T15783 | 27717-27722 | http://purl.obolibrary.org/obo/GO_0004908 | denotes | IL-1R |
T15782 | 27566-27571 | http://purl.obolibrary.org/obo/GO_0004908 | denotes | IL-1R |
T14599 | 26781-26788 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T14598 | 26771-26788 | http://purl.obolibrary.org/obo/GO_0043130 | denotes | ubiquitin-binding |
T14597 | 26771-26780 | http://purl.obolibrary.org/obo/GO_0031386 | denotes | ubiquitin |
T14596 | 25588-25611 | http://purl.obolibrary.org/obo/GO_0004843 | denotes | deubiquitinating enzyme |
T13150 | 23810-23827 | http://purl.obolibrary.org/obo/GO_0043130 | denotes | ubiquitin-binding |
T13149 | 23177-23194 | http://purl.obolibrary.org/obo/GO_0043130 | denotes | ubiquitin-binding |
T13148 | 23810-23819 | http://purl.obolibrary.org/obo/GO_0031386 | denotes | ubiquitin |
T13147 | 23177-23186 | http://purl.obolibrary.org/obo/GO_0031386 | denotes | ubiquitin |
T13146 | 23820-23827 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T13145 | 23187-23194 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T13144 | 22870-22877 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T10723 | 20680-20685 | http://purl.obolibrary.org/obo/GO_0030367 | denotes | IL-17 |
T10722 | 20654-20664 | http://purl.obolibrary.org/obo/GO_0042056 | denotes | attractant |
T10721 | 20618-20622 | http://purl.obolibrary.org/obo/GO_0005138 | denotes | IL-6 |
T10720 | 18887-18904 | http://purl.obolibrary.org/obo/GO_0008157 | denotes | binding protein 1 |
T10719 | 18887-18902 | http://purl.obolibrary.org/obo/GO_0005515 | denotes | binding protein |
T10718 | 18792-18809 | http://purl.obolibrary.org/obo/GO_0043130 | denotes | ubiquitin-binding |
T10717 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0061667 | denotes | E3 |
T10716 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0061666 | denotes | E3 |
T10715 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0061665 | denotes | E3 |
T10714 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0061664 | denotes | E3 |
T10713 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0061663 | denotes | E3 |
T10712 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0061662 | denotes | E3 |
T10711 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0061661 | denotes | E3 |
T10710 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0061660 | denotes | E3 |
T10709 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0061659 | denotes | E3 |
T10708 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0061630 | denotes | E3 |
T10707 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0061658 | denotes | E2 |
T10706 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0061657 | denotes | E2 |
T10705 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0061656 | denotes | E2 |
T10704 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0061655 | denotes | E2 |
T10703 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0061654 | denotes | E2 |
T8758 | 17680-17683 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T5681 | 15780-15784 | http://purl.obolibrary.org/obo/GO_0005138 | denotes | IL-6 |
T5680 | 15761-15764 | http://purl.obolibrary.org/obo/GO_0004705 | denotes | JNK |
T5679 | 13777-13780 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T5678 | 13725-13728 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T5677 | 13426-13429 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T5676 | 13330-13333 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T5675 | 13185-13188 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T5674 | 13179-13182 | http://purl.obolibrary.org/obo/GO_0004704 | denotes | NIK |
T5673 | 12385-12390 | http://purl.obolibrary.org/obo/GO_0004908 | denotes | IL-1R |
T5672 | 12065-12078 | http://purl.obolibrary.org/obo/GO_0004908 | denotes | IL-1 receptor |
T5671 | 11767-11775 | http://purl.obolibrary.org/obo/GO_0043495 | denotes | anchored |
T5670 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0061658 | denotes | E2 |
T5669 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0061657 | denotes | E2 |
T5668 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0061656 | denotes | E2 |
T5667 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0061655 | denotes | E2 |
T5666 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0061654 | denotes | E2 |
T5665 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0061653 | denotes | E2 |
T5664 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0061652 | denotes | E2 |
T5663 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0061651 | denotes | E2 |
T5630 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0061660 | denotes | E3 |
T5629 | 11589-11591 | http://purl.obolibrary.org/obo/GO_0061659 | denotes | E3 |
T5628 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0061659 | denotes | E3 |
T5627 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0061659 | denotes | E3 |
T5626 | 11589-11591 | http://purl.obolibrary.org/obo/GO_0061630 | denotes | E3 |
T5625 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0061630 | denotes | E3 |
T5624 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0061630 | denotes | E3 |
T5623 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0019787 | denotes | E2 |
T5622 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0019787 | denotes | E3 |
T5621 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0019787 | denotes | E3 |
T5620 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0004842 | denotes | E2 |
T5619 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0004842 | denotes | E3 |
T5618 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0004842 | denotes | E3 |
T5617 | 12606-12609 | http://purl.obolibrary.org/obo/GO_0008384 | denotes | IKK |
T5616 | 11459-11462 | http://purl.obolibrary.org/obo/GO_0008384 | denotes | IKK |
T5615 | 8220-8223 | http://purl.obolibrary.org/obo/GO_0008384 | denotes | IKK |
T5614 | 8063-8066 | http://purl.obolibrary.org/obo/GO_0008384 | denotes | IKK |
T5613 | 12065-12069 | http://purl.obolibrary.org/obo/GO_0005149 | denotes | IL-1 |
T5612 | 7813-7817 | http://purl.obolibrary.org/obo/GO_0005149 | denotes | IL-1 |
T5611 | 15340-15346 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | ligand |
T5610 | 7845-7852 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | ligands |
T5609 | 11498-11505 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T5608 | 7215-7222 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T5607 | 7211-7222 | http://purl.obolibrary.org/obo/GO_0003677 | denotes | DNA binding |
T810 | 2682-2688 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | ligand |
T809 | 1942-1963 | http://purl.obolibrary.org/obo/GO_0050998 | denotes | nitric oxide synthase |
T808 | 1942-1963 | http://purl.obolibrary.org/obo/GO_0004517 | denotes | nitric oxide synthase |
T807 | 1907-1916 | http://purl.obolibrary.org/obo/GO_0016701 | denotes | oxygenase |
T806 | 1895-1899 | http://purl.obolibrary.org/obo/GO_0005138 | denotes | IL-6 |
T805 | 2043-2047 | http://purl.obolibrary.org/obo/GO_0005149 | denotes | IL-1 |
T804 | 1889-1893 | http://purl.obolibrary.org/obo/GO_0005149 | denotes | IL-1 |
T10702 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0061653 | denotes | E2 |
T10701 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0061652 | denotes | E2 |
T10700 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0061651 | denotes | E2 |
T10699 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0061650 | denotes | E2 |
T10698 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0061631 | denotes | E2 |
T10697 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0019787 | denotes | E3 |
T10696 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0019787 | denotes | E2 |
T10695 | 18589-18591 | http://purl.obolibrary.org/obo/GO_0004842 | denotes | E3 |
T10694 | 18533-18535 | http://purl.obolibrary.org/obo/GO_0004842 | denotes | E2 |
T10693 | 18887-18894 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T10692 | 18842-18849 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T10691 | 18802-18809 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T10690 | 18202-18209 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
T10689 | 18191-18209 | http://purl.obolibrary.org/obo/GO_0000166 | denotes | nucleotide-binding |
T10688 | 20673-20682 | http://purl.obolibrary.org/obo/GO_0005149 | denotes | 1, and IL |
T10687 | 18137-18141 | http://purl.obolibrary.org/obo/GO_0005149 | denotes | IL-1 |
T10686 | 18792-18801 | http://purl.obolibrary.org/obo/GO_0031386 | denotes | ubiquitin |
T10685 | 18592-18601 | http://purl.obolibrary.org/obo/GO_0031386 | denotes | ubiquitin |
T10684 | 18536-18545 | http://purl.obolibrary.org/obo/GO_0031386 | denotes | ubiquitin |
T10683 | 17986-17995 | http://purl.obolibrary.org/obo/GO_0031386 | denotes | ubiquitin |
T5662 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0061650 | denotes | E2 |
T5661 | 11586-11588 | http://purl.obolibrary.org/obo/GO_0061631 | denotes | E2 |
T5660 | 11498-11514 | http://purl.obolibrary.org/obo/GO_0005515 | denotes | binding proteins |
T5659 | 11488-11514 | http://purl.obolibrary.org/obo/GO_0032182 | denotes | ubiquitin-binding proteins |
T5658 | 11488-11514 | http://purl.obolibrary.org/obo/GO_0031625 | denotes | ubiquitin-binding proteins |
T5657 | 11488-11505 | http://purl.obolibrary.org/obo/GO_0043130 | denotes | ubiquitin-binding |
T5656 | 11488-11497 | http://purl.obolibrary.org/obo/GO_0031386 | denotes | ubiquitin |
T5655 | 11083-11092 | http://purl.obolibrary.org/obo/GO_0031386 | denotes | ubiquitin |
T5654 | 10988-10997 | http://purl.obolibrary.org/obo/GO_0031386 | denotes | ubiquitin |
T5653 | 11589-11591 | http://purl.obolibrary.org/obo/GO_0061667 | denotes | E3 |
T5652 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0061667 | denotes | E3 |
T5651 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0061667 | denotes | E3 |
T5650 | 11589-11591 | http://purl.obolibrary.org/obo/GO_0061666 | denotes | E3 |
T5649 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0061666 | denotes | E3 |
T5648 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0061666 | denotes | E3 |
T5647 | 11589-11591 | http://purl.obolibrary.org/obo/GO_0061665 | denotes | E3 |
T5646 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0061665 | denotes | E3 |
T5645 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0061665 | denotes | E3 |
T5644 | 11589-11591 | http://purl.obolibrary.org/obo/GO_0061664 | denotes | E3 |
T5643 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0061664 | denotes | E3 |
T5642 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0061664 | denotes | E3 |
T5641 | 11589-11591 | http://purl.obolibrary.org/obo/GO_0061663 | denotes | E3 |
T5640 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0061663 | denotes | E3 |
T5639 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0061663 | denotes | E3 |
T5638 | 11589-11591 | http://purl.obolibrary.org/obo/GO_0061662 | denotes | E3 |
T5637 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0061662 | denotes | E3 |
T5636 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0061662 | denotes | E3 |
T5635 | 11589-11591 | http://purl.obolibrary.org/obo/GO_0061661 | denotes | E3 |
T5634 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0061661 | denotes | E3 |
T5633 | 10985-10987 | http://purl.obolibrary.org/obo/GO_0061661 | denotes | E3 |
T5632 | 11589-11591 | http://purl.obolibrary.org/obo/GO_0061660 | denotes | E3 |
T5631 | 11080-11082 | http://purl.obolibrary.org/obo/GO_0061660 | denotes | E3 |
T15781 | 27494-27499 | http://purl.obolibrary.org/obo/GO_0004908 | denotes | IL-1R |
T15780 | 27410-27423 | http://purl.obolibrary.org/obo/GO_0004908 | denotes | IL-1 receptor |
T15779 | 27358-27371 | http://purl.obolibrary.org/obo/GO_0004908 | denotes | IL-1 receptor |
T15778 | 27410-27414 | http://purl.obolibrary.org/obo/GO_0005149 | denotes | IL-1 |
T15777 | 27358-27362 | http://purl.obolibrary.org/obo/GO_0005149 | denotes | IL-1 |
T15776 | 27395-27409 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | immunoglobulin |
T15775 | 27343-27357 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | immunoglobulin |
T2530 | 6455-6471 | http://purl.obolibrary.org/obo/GO_0005515 | denotes | binding proteins |
T2529 | 6447-6471 | http://purl.obolibrary.org/obo/GO_0048306 | denotes | calcium-binding proteins |
T2528 | 6202-6212 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibodies |
T2527 | 4716-4726 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibodies |
T2526 | 4538-4548 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibodies |
T2525 | 6874-6881 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | ligands |
T2524 | 6635-6642 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | ligands |
T2523 | 6104-6111 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | ligands |
T2522 | 5632-5639 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | ligands |
T2521 | 5385-5392 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | ligands |
T2520 | 5341-5348 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | ligands |
T2519 | 4227-4233 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | ligand |
T2518 | 4207-4214 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | Binding |
T2517 | 3458-3462 | http://purl.obolibrary.org/obo/GO_0005149 | denotes | IL-1 |
T2516 | 3324-3328 | http://purl.obolibrary.org/obo/GO_0005149 | denotes | IL-1 |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T21779 | 14050-14084 | http://purl.obolibrary.org/obo/GO_0000153 | denotes | complex with the ubiquitin ligases |
T21778 | 14050-14084 | http://purl.obolibrary.org/obo/GO_0000151 | denotes | complex with the ubiquitin ligases |
T21777 | 14573-14577 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T21776 | 14022-14027 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T20066 | 9931-9944 | http://purl.obolibrary.org/obo/GO_0044214 | denotes | transmembrane |
T20065 | 9931-9944 | http://purl.obolibrary.org/obo/GO_0016021 | denotes | transmembrane |
T20064 | 9356-9363 | http://purl.obolibrary.org/obo/GO_0005634 | denotes | nucleus |
T20063 | 8622-8630 | http://purl.obolibrary.org/obo/GO_0016020 | denotes | membrane |
T18008 | 31281-31286 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T18007 | 31193-31198 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T16703 | 29498-29503 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T16702 | 29356-29361 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T16701 | 29140-29145 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T16700 | 28979-28983 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T14604 | 26249-26253 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T14603 | 26015-26019 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T14602 | 25922-25926 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T14601 | 25685-25689 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T14600 | 25494-25498 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T13151 | 25044-25048 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T10734 | 21850-21860 | http://purl.obolibrary.org/obo/GO_0005694 | denotes | chromosome |
T10733 | 21561-21566 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T10732 | 21550-21555 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T10731 | 21541-21546 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T10730 | 21477-21481 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T10729 | 19973-19977 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T10728 | 19906-19910 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T10727 | 19026-19030 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T8760 | 16339-16344 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T8759 | 16007-16025 | http://purl.obolibrary.org/obo/GO_0042995 | denotes | cellular processes |
T5694 | 15719-15724 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T5693 | 13323-13328 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T5692 | 13295-13299 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T5691 | 12967-12971 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T5690 | 12065-12078 | http://purl.obolibrary.org/obo/GO_0045323 | denotes | IL-1 receptor |
T5689 | 11592-11606 | http://purl.obolibrary.org/obo/GO_1902494 | denotes | enzyme complex |
T5688 | 13476-13486 | http://purl.obolibrary.org/obo/GO_0000502 | denotes | proteasome |
T5687 | 12849-12859 | http://purl.obolibrary.org/obo/GO_0000502 | denotes | proteasome |
T5686 | 8199-8209 | http://purl.obolibrary.org/obo/GO_0000502 | denotes | proteasome |
T5685 | 8220-8231 | http://purl.obolibrary.org/obo/GO_0008385 | denotes | IKK complex |
T5684 | 8063-8075 | http://purl.obolibrary.org/obo/GO_0008385 | denotes | IKK) complex |
T5683 | 7428-7435 | http://purl.obolibrary.org/obo/GO_0005634 | denotes | nucleus |
T5682 | 7062-7071 | http://purl.obolibrary.org/obo/GO_0005737 | denotes | cytoplasm |
T812 | 1265-1270 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T811 | 1021-1026 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T21785 | 14050-14084 | http://purl.obolibrary.org/obo/GO_0000836 | denotes | complex with the ubiquitin ligases |
T21784 | 14050-14084 | http://purl.obolibrary.org/obo/GO_0043494 | denotes | complex with the ubiquitin ligases |
T21783 | 14050-14084 | http://purl.obolibrary.org/obo/GO_0019005 | denotes | complex with the ubiquitin ligases |
T21782 | 14050-14084 | http://purl.obolibrary.org/obo/GO_0000152 | denotes | complex with the ubiquitin ligases |
T21781 | 14050-14084 | http://purl.obolibrary.org/obo/GO_0000837 | denotes | complex with the ubiquitin ligases |
T21780 | 14050-14084 | http://purl.obolibrary.org/obo/GO_0000835 | denotes | complex with the ubiquitin ligases |
T15786 | 28133-28138 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T15785 | 27962-27967 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T15784 | 27922-27927 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T2543 | 5954-5963 | http://purl.obolibrary.org/obo/GO_0000785 | denotes | chromatin |
T2542 | 5904-5915 | http://purl.obolibrary.org/obo/GO_0005694 | denotes | chromosomal |
T2541 | 5428-5432 | http://purl.obolibrary.org/obo/GO_0018995 | denotes | host |
T2540 | 6202-6212 | http://purl.obolibrary.org/obo/GO_0042571 | denotes | antibodies |
T2539 | 4716-4726 | http://purl.obolibrary.org/obo/GO_0042571 | denotes | antibodies |
T2538 | 4538-4548 | http://purl.obolibrary.org/obo/GO_0042571 | denotes | antibodies |
T2537 | 6202-6212 | http://purl.obolibrary.org/obo/GO_0019815 | denotes | antibodies |
T2536 | 4716-4726 | http://purl.obolibrary.org/obo/GO_0019815 | denotes | antibodies |
T2535 | 4538-4548 | http://purl.obolibrary.org/obo/GO_0019815 | denotes | antibodies |
T2534 | 6053-6058 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T2533 | 5445-5450 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T2532 | 4812-4816 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T2531 | 3993-3997 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T2547 | 6724-6734 | http://purl.obolibrary.org/obo/GO_0005577 | denotes | fibrinogen |
T2546 | 6684-6715 | http://purl.obolibrary.org/obo/GO_0044420 | denotes | extracellular matrix components |
T2545 | 6684-6704 | http://purl.obolibrary.org/obo/GO_0031012 | denotes | extracellular matrix |
T2544 | 6684-6697 | http://purl.obolibrary.org/obo/GO_0005576 | denotes | extracellular |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T21404 | 14223-14387 | Sentence | denotes | Upon ligand binding, TRAF3 is recruited to the receptor, where TRAF2 directs nondegradative K63-linked polyubiquitination of cIAP1/2, resulting in their activation. |
T21403 | 14006-14222 | Sentence | denotes | In unstimulated cells NIK forms a cytosolic complex with the ubiquitin ligases TRAF2, TRAF3 and cIAP1/2, which facilitates the K48-linked polyubiquitination and proteasomal degradation of NIK, keeping NIK levels low. |
T21402 | 13880-14005 | Sentence | denotes | CD40 and RANK can activate the noncanonical NF-κB pathway that is dependent on NF-κB inducing kinase (NIK) expression levels. |
T21401 | 13849-13879 | Sentence | denotes | Noncanonical NF-κB signalling. |
T21409 | 14831-15166 | Sentence | denotes | Next to TRAF3, TRAF1 has also been identified as a negative regulator of this pathway, most probably by competing with other TNF receptor-associated factors. cIAP, cellular inhibitor of apoptosis; IKK, IκB kinase; NF, nuclear factor; RANK, receptor activator of NF-κB; TRAF, TNF receptor-associated factor; TNF, tumour necrosis factor. |
T21408 | 14666-14830 | Sentence | denotes | This is followed by K48-linked polyubiquitination and partial proteasomal degradation of p100 to p52, which forms a heterodimer with RelB to activate transcription. |
T21407 | 14579-14665 | Sentence | denotes | NIK then phosphorylates and activates IKK1, which mediates NF-κB p100 phosphorylation. |
T21406 | 14478-14578 | Sentence | denotes | As a result, TRAF3 is degraded and NIK is stabilised, resulting in increased NIK levels in the cell. |
T21405 | 14388-14477 | Sentence | denotes | Subsequently cIAP1/2 directs its K48-linked polyubiquitination to TRAF3, rather than NIK. |
T19469 | 10194-10724 | Sentence | denotes | ABIN, A20-binding inhibitor of NF-κB; cIAP, cellular inhibitor of apoptosis; CYLD, cylindromatosis; IKK, IκB kinase; IκB, inhibitor of NF-κB; IRAK, IL-1R-associated kinase; MyD88, myeloid differentiation primary response gene 88; NEMO, NF-κB essential modulator; NF, nuclear factor; RANK, receptor activator of NF-κB; RIP1, receptor interacting protein 1; SIGIRR, single-immunoglobulinIL-1 receptor-related; TIR, Toll-like receptor/IL-1R; TRAF, TNF receptor-associated factor; TLR, Toll-like receptor; TNF, tumour necrosis factor. |
T19468 | 10038-10193 | Sentence | denotes | The expression of many of these negative regulatory molecules is NF-κB dependent, implicating them in the negative feedback regulation of NF-κB activation. |
T19467 | 9878-10037 | Sentence | denotes | Finally, TLR signalling can also be inhibited by the transmembrane protein SIGIRR, which has been proposed to compete with TLR4 for binding to IRAK1 and TRAF6. |
T19466 | 9534-9877 | Sentence | denotes | A20 and CYLD are deubiquitinating enzymes that control NF-κB activation by targeting specific signalling proteins including RIP1 and TRAF6, to which they are recruited using specific ubiquitin-binding adaptor proteins such as ABIN-1 and p62. miR-146 is thought to negatively regulate TLR signalling by inhibiting expression of IRAK1 and TRAF6. |
T19465 | 9400-9533 | Sentence | denotes | TRAF1, which has no ubiquitin ligase activity, can negatively regulate NF-κB activation, most probably by competing with other TRAFs. |
T19464 | 9271-9399 | Sentence | denotes | This allows NF-κB (here shown as a heterodimer of p65 and p50) to translocate to the nucleus and promote target gene expression. |
T19463 | 9121-9270 | Sentence | denotes | TAK1 then phosphorylates and activates IKK2, which in turn phosphorylates IκBα, triggering its K48-linked ubiquitination and proteasomal degradation. |
T19462 | 8950-9120 | Sentence | denotes | K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1, is recognised by NEMO and TAB proteins, resulting in the recruitment and activation of respectively IKK2 and TAK1. |
T19461 | 8592-8949 | Sentence | denotes | Ligand engagement of specific membrane receptors such as TNFR1, CD40, RANK, and TLR4 trigger the recruitment of specific adaptor proteins (TNF receptor 1-associated death domain protein (TRADD), MyD88, MAL, TIR domain-containing adaptor-inducing IFNβ (TRIF)), kinases (RIP1, IRAK1, IRAK4), and ubiquitin ligases (TRAF2, TRAF6, cIAP1, cIAP2) to the receptor. |
T19460 | 8540-8591 | Sentence | denotes | Canonical NF-κB signalling and negative regulators. |
T17449 | 32629-32809 | Sentence | denotes | Finally, miR-16, miR-132, and miR-223 were also shown to have an altered expression in RA patients, indicating their potential as diagnostic biomarkers for pathogenesis [83,88,91]. |
T17448 | 32470-32628 | Sentence | denotes | Similarly, elevated levels of miR-203 - leading to increased secretion of matrix metalloproteinase-1 and IL-6 - were detected in RA synovial fibroblasts [90]. |
T17447 | 32307-32469 | Sentence | denotes | In this context, miR-124a - a key regulator of the chemokine monocyte chemoattractant protein 1 - was shown to be decreased in synoviocytes from RA patients [89]. |
T17446 | 32132-32306 | Sentence | denotes | Besides miR-146 and miR-155, a number of other miRNAs with a potential role in the control of NF-κB-dependent inflammatory responses in RA pathology were recently identified. |
T17445 | 31905-32131 | Sentence | denotes | In addition, their increased expression in RA patients is potentially useful as a marker for disease diagnosis, progression, or treatment efficacy [88], but this will require confirmation using a large and well-defined cohort. |
T17444 | 31641-31904 | Sentence | denotes | Moreover, miR-155 was shown to promote TNF production, a key process in the pathogenesis of RA [87]. miR-146 and miR-155 may therefore be important negative regulators of inflammation in RA and their potential for the development of new treatments is substantial. |
T17443 | 31313-31640 | Sentence | denotes | Interestingly, a polymorphism in the 3'-UTR of the miR-146a target gene was recently shown to be associated with RA susceptibility [86]. miR-155 overexpression in synovial fibroblasts was able to prevent the TLR and cytokine-inducible expression of specific matrix metalloproteinases that mediate tissue destruction in RA [81]. |
T17442 | 31029-31312 | Sentence | denotes | Notably, both miR-146 and miR-155 are expressed at higher levels in RA synovial fibroblasts and synovial tissue [81,82], as well as in peripheral blood mononuclear cells of RA patients [83]. miR-146a is also overexpressed in CD4+ and IL-17-producing T cells from RA patients [84,85]. |
T17441 | 30920-31028 | Sentence | denotes | Similarly, miR-155 was shown to target transcripts for the NF-κB signalling molecules IKKε and RIP1 [79,80]. |
T17440 | 30758-30919 | Sentence | denotes | In addition, miR-146a is an NF-κB-dependent gene, and the NF-κB signalling molecules IRAK1 and TRAF6 were identified as target genes of miR-146a [78] (Figure 1). |
T17439 | 30575-30757 | Sentence | denotes | miR-146a/b and miR-155 are of particular interest for inflammatory signalling to NF-κB, since these miRNAs can be induced by inflammatory stimuli such as IL-1β, TNF and TLRs [78,79]. |
T17438 | 30439-30574 | Sentence | denotes | They bind the 3'-UTR of target mRNAs leading to the repression of protein expression and the promotion of target mRNA degradation [77]. |
T17437 | 30228-30438 | Sentence | denotes | miRNAs are recently discovered regulators of gene expression and represent a class of noncoding RNA molecules essential in many cellular and developmental processes, including immune responses and inflammation. |
T17436 | 30218-30227 | Sentence | denotes | microRNAs |
T16375 | 30110-30216 | Sentence | denotes | Recent work in a Korean population also demonstrates genetic association of the TRAF1 region with RA [76]. |
T16374 | 30026-30109 | Sentence | denotes | Subsequent work indicates that TRAF1 is more likely to be the causative locus [75]. |
T16373 | 29776-30025 | Sentence | denotes | A genome-wide association study examining more than 300,000 SNPs among approximately 1,500 autoantibody-positive RA cases and 1,800 controls identified a genetic variation at the TRAF1-complement component 5 locus as an important RA risk locus [74]. |
T16372 | 29693-29775 | Sentence | denotes | Alternatively, TRAF1 might recruit A20 with which it can physically interact [73]. |
T16371 | 29580-29692 | Sentence | denotes | Most probably, TRAF1 competes with TRAF family members for binding to the receptor or other signalling proteins. |
T16370 | 29505-29579 | Sentence | denotes | The mechanism by which TRAF1 modulates NF- κB activation is still unclear. |
T16369 | 29330-29504 | Sentence | denotes | TRAF1-deficient dendritic cells, however, show attenuated responses to secondary stimulation by TRAF2-dependent factors, suggesting a positive regulatory role in these cells. |
T16368 | 29251-29329 | Sentence | denotes | TRAF1 also functions as a negative regulator of CD40-induced NF-κB activation. |
T16367 | 29122-29250 | Sentence | denotes | TRAF1-deficient T cells are hyper-responsive to TNF, with enhanced proliferation and activation of the NF-κB signalling pathway. |
T16366 | 29015-29121 | Sentence | denotes | Expression of TRAF1 is inducible by TNF and overexpression of TRAF1 inhibits TNF-induced NF-κB activation. |
T16365 | 28825-29014 | Sentence | denotes | Accumulating data support a role for TRAF1 as both a negative and a positive modulator of NF-κB signalling by certain TNF family receptors, possibly in a cell-type-dependent manner [71,72]. |
T16364 | 28688-28824 | Sentence | denotes | TRAF1 is a unique member of the TRAF protein family because it lacks a RING finger domain and therefore lacks ubiquitin ligase activity. |
T16363 | 28655-28687 | Sentence | denotes | TNF receptor-associated factor 1 |
T15491 | 28548-28653 | Sentence | denotes | Because of its restricted expression pattern, SIGIRR may also be an interesting therapeutic target in RA. |
T15490 | 28353-28547 | Sentence | denotes | It will be interesting to compare the expression of SIGIRR in RA patients with its expression in control patients, or to investigate whether the function of SIGIRR is compromised in RA patients. |
T15489 | 28140-28352 | Sentence | denotes | This inhibitory function of SIGIRR was further confirmed in vivo, since SIGIRR-deficient mice developed a more severe disease in zymosan-induced arthritis, as well as collagen-induced arthritis mouse models [70]. |
T15488 | 28009-28139 | Sentence | denotes | Recently, SIGIRR overexpression was shown to inhibit the spontaneous release of inflammatory cytokines by human RA synovial cells. |
T15487 | 27843-28008 | Sentence | denotes | SIGIRR has a very restricted expression pattern, being expressed in epithelial cells, monocytes and immature dendritic cells, but not in mature macro-phages [69,70]. |
T15486 | 27689-27842 | Sentence | denotes | Given the important role of IL-1R and TLR signalling in the chronic inflammation observed in RA [68], a regulatory role for SIGIRR in RA is not unlikely. |
T15485 | 27388-27688 | Sentence | denotes | Single-immunoglobulin IL-1 receptor-related (SIGIRR) protein, also known as TIR-8, is a member of the TLR/IL-1R family that has been extensively characterised as an inhibitor of IL-1R and TLR signalling, probably through direct interaction with these receptors, MyD88, IRAK1 or TRAF6 [67] (Figure 1). |
T15484 | 27336-27387 | Sentence | denotes | Single-immunoglobulin IL-1 receptor-related protein |
T14151 | 27078-27334 | Sentence | denotes | These findings suggest that CYLD-mediated inhibi-tion of RANK-induced NF-κB signalling plays a key role in the negative regulation of osteoclastogenesis and indicate CYLD as a potential genetic factor involved in the pathology of bone disorders such as RA. |
T14150 | 26903-27077 | Sentence | denotes | In this context, it is worth mentioning that transgenic mice expressing a mutated form of p62 also display abnormal osteoclastogenesis and develop progressive bone loss [66]. |
T14149 | 26630-26902 | Sentence | denotes | CYLD expression is markedly upregulated under conditions of RANKL-induced osteoclastogenesis and is recruited to ubiquitinated TRAF6 via the ubiquitin-binding adaptor protein p62 (also known as sequestosome 1) [65], followed by the CYLD-mediated deubiquitination of TRAF6. |
T14148 | 26499-26629 | Sentence | denotes | Osteoclast precursors of these mice are hyper-responsive to RANKL-induced differentiation and produce more and larger osteoclasts. |
T14147 | 26386-26498 | Sentence | denotes | Mice with a genetic deficiency of CYLD have aberrant osteoclast differentiation and develop severe osteoporosis. |
T14146 | 26275-26385 | Sentence | denotes | Interestingly, CYLD has been shown to negatively regulate RANK signalling and osteoclastogenesis in mice [65]. |
T14145 | 26198-26274 | Sentence | denotes | In addition, their relative activity might also be cell-type dependent [64]. |
T14144 | 25982-26197 | Sentence | denotes | As A20 is only expressed in many cell types upon stimulation, it has been suggested that this protein mainly regulates later phases of NF-κB signalling, whereas CYLD would regulate constitutive and early signalling. |
T14143 | 25849-25981 | Sentence | denotes | Many of these are also targeted by A20 and it is still not clear why the cell needs A20 as well as CYLD to control NF-κB activation. |
T14142 | 25578-25848 | Sentence | denotes | CYLD is a deubiquitinating enzyme that negatively regulates NF-κB signalling initiated by TNFR, RANK and T-cell receptor stimulation (reviewed in [64]) (Figure 1), by deubiquitina-ting several NF-κB signalling proteins including NEMO, TRAF2, TRAF6, TRAF7, RIP1 and TAK1. |
T14141 | 25385-25577 | Sentence | denotes | CYLD is also involved, however, in diverse physiological processes ranging from immunity and inflammation to cell cycle progression, spermatogenesis, and osteoclastogenesis (reviewed in [64]). |
T14140 | 25262-25384 | Sentence | denotes | Cylindromatosis (CYLD) protein was originally identified as a tumour suppressor involved in familial cylindromatosis [63]. |
T14139 | 25238-25261 | Sentence | denotes | Cylindromatosis protein |
T12654 | 25072-25236 | Sentence | denotes | It will therefore be interesting to investigate whether SNPs that have been reported to be associated with systemic lupus erythematosus are also associated with RA. |
T12653 | 24788-25071 | Sentence | denotes | A high degree of overlap between systemic lupus erythematosus and RA susceptibility loci might be expected as the two diseases show some clinical overlap in joint involvement, autoantibody production, systemic features and response to treatments such as B-cell depletion (rituximab). |
T12652 | 24664-24787 | Sentence | denotes | Interestingly, ABIN-1 polymorphisms have been associated with psoriasis and systemic lupus erythematosus in humans [61,62]. |
T12651 | 24542-24663 | Sentence | denotes | Moreover, this protective effect of the ITAM was strongly suppressed in inflammatory arthritis synovial macrophages [60]. |
T12650 | 24333-24541 | Sentence | denotes | In a recent study, inhibition of TLR responses by immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptors was shown to depend on the expression of the NF-κB inhibitory proteins ABIN-3 and A20. |
T12649 | 24005-24332 | Sentence | denotes | Using oligonucleotide microarray analysis, ABIN-1 was identified among TNF-induced genes in human synoviocytes, and high levels of ABIN-1 mRNA were detected in RA tissue biopsies, indicating a potential role for ABIN-1, together with A20, in the negative feedback regulation of NF-κB signalling and the pathogenesis of RA [59]. |
T12648 | 23841-24004 | Sentence | denotes | As for A20, ABIN-1 also strongly inhibits TNF-induced apoptosis [58], and ABIN-1 deficient mice die embryonically due to TNF-dependent foetal liver apoptosis [56]. |
T12647 | 23696-23840 | Sentence | denotes | Functional ABIN-3 is expressed in humans, but mice only express a truncated and inactive form lacking the crucial ubiquitin-binding domain [57]. |
T12646 | 23476-23695 | Sentence | denotes | Unexpectedly, both ABIN-1-deficient and ABIN-2-deficient mice exhibit only slightly increased or normal NF-κB responses, respectively, possibly reflecting redundant NF-κB inhibitory activities of multiple ABINs [55,56]. |
T12645 | 23281-23475 | Sentence | denotes | Similar to A20, ABIN-1 and ABIN-3 expression is NF-κB dependent, implicating a potential role for the A20/ABIN complex in the negative feedback regulation of NF-κB activation (reviewed in [54]). |
T12644 | 23144-23280 | Sentence | denotes | Because ABINs contain a specific ubiquitin-binding motif, they have been proposed to target A20 to polyubiquitinated substrates [43,44]. |
T12643 | 22898-23143 | Sentence | denotes | ABIN-1, ABIN-2 and ABIN-3 (also known as TNIP-1, TNIP-2, and TNIP-3) were identified as ubiquitously expressed A20 interacting proteins and were shown to inhibit NF-κB activation by TNF and several other inflammatory stimuli upon overexpression. |
T12642 | 22866-22897 | Sentence | denotes | A20-binding inhibitors of NF-κB |
T9668 | 22739-22864 | Sentence | denotes | In this context, knockin mice for the corresponding A20 SNPs, combined with mouse models for RA, will be very valuable tools. |
T9667 | 22613-22738 | Sentence | denotes | It will be of interest to identify the actual causal variants and to elucidate the functional consequences of these variants. |
T9666 | 22388-22612 | Sentence | denotes | Recently, Elsby and colleagues functionally evaluated in vitro the regulatory ability of RA-associated SNP variants on A20 promoter activity, and could show repressed A20 transcription for some of the SNPs investigated [53]. |
T9665 | 22294-22387 | Sentence | denotes | How these variants affect normal A20 activity and how they cause RA, however, remain unclear. |
T9664 | 22113-22293 | Sentence | denotes | As A20 is required for termination of TNF-induced signals, and TNF is the primary inflammatory cytokine in RA, these findings reveal A20 as a candidate susceptibility locus for RA. |
T9663 | 21892-22112 | Sentence | denotes | Although the identified variants are not located in a gene, they are thought to influence A20 as its nearest gene (~150 kb downstream of A20), probably by the presence of potential regulatory DNA elements in this region. |
T9662 | 21729-21891 | Sentence | denotes | Several genome-wide association studies also revealed a clear association between mutations in the A20 locus in the 6q23 chromosome and susceptibility to RA [52]. |
T9661 | 21568-21728 | Sentence | denotes | Importantly, several SNPs in the human A20 locus have been associated with increased susceptibility to development of autoimmune pathologies (reviewed in [52]). |
T9660 | 21359-21567 | Sentence | denotes | It will be interesting to analyse in future the susceptibility of conditional knockout mice that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells. |
T9659 | 21257-21358 | Sentence | denotes | A20 might therefore minimise joint destruction through decreasing the osteoclast number and activity. |
T9658 | 21128-21256 | Sentence | denotes | This study also demonstrated that A20 overexpression leads to a decrease in the number of activated osteoclasts in joint tissue. |
T9657 | 20853-21127 | Sentence | denotes | Because TNF and IL-1β are known to mediate synovitis, pannus formation, and erosion of cartilage and bone in RA, the decreased serum levels of TNF and IL-1β in A20-transduced mice might explain the beneficial effects in the clinical, pathological, and radiological findings. |
T9656 | 20499-20852 | Sentence | denotes | A20 expression in synovial tissue was associated with inhibition of NF-κB activity and decreased levels of TNF, IL-1β, IL-6, soluble RANKL, monocyte chemo-attractant protein 1, and IL-17, suggesting that A20 induces a protective effect in collagen-induced arthritis mice through suppression of NF-κB activation and NF- κB-dependent gene expression [51]. |
T9655 | 20229-20498 | Sentence | denotes | Recently, intra-articular injection of an A20-expressing adenovirus was shown to reduce the severity of synovial inflammation and joint destruction in a mouse model of collagen-induced arthritis, even in untreated joints, in both a prophylactic and therapeutic setting. |
T9654 | 20091-20228 | Sentence | denotes | Interestingly, A20 expression is itself regulated by NF-κB [50], implicating A20 in the negative feedback regulation of NF-κB signalling. |
T9653 | 19929-20090 | Sentence | denotes | A20 expression has been observed in several cell types that play important roles in the pathophysiology of RA, such as fibroblasts, synoviocytes and lymphocytes. |
T9652 | 19749-19928 | Sentence | denotes | Two independent studies showed that mice lacking A20 in B cells develop autoimmunity due to hyperactive NF-κB responses in B cells leading to unrestricted B-cell survival [48,49]. |
T9651 | 19433-19748 | Sentence | denotes | We recently showed that mice specifically lacking A20 in intestinal epithelial cells exhibit increased susceptibility to experimental colitis due to the hypersensitivity of their intestinal epithelial cells to TNF-induced apoptosis, confirming A20 as a major antiapoptotic protein in the intestinal epithelium [47]. |
T9650 | 19311-19432 | Sentence | denotes | A20-deficient cells are also more susceptible to TNF-mediated apoptosis, confirming its role as an antiapoptotic protein. |
T9649 | 19126-19310 | Sentence | denotes | A20-deficient mice spontaneously develop multiorgan inflammation and cachexia and die within 2 weeks of birth, illustrating the potent anti-inflammatory function of this molecule [46]. |
T9648 | 19038-19125 | Sentence | denotes | The mechanisms by which A20 regulates apoptotic signalling, however, are still elusive. |
T9647 | 18914-19037 | Sentence | denotes | Next to its role in suppressing NF-κB activation, A20 is also a strong inhibitor of apoptosis, at least in some cell types. |
T9646 | 18734-18913 | Sentence | denotes | The association of A20 with its targets requires specific ubiquitin-binding adaptor proteins, including A20-binding inhibitor of NF-κB (ABIN) 1 and Tax1-binding protein 1 [43-46]. |
T9645 | 18484-18733 | Sentence | denotes | Recently, the disruption of interactions between E2 ubiquitin conjugating enzymes (Ubc13 and Ubc5hc) and E3 ubiquitin ligases (TRAF6, TRAF2 and cIAP1/2) were described as another important mechanism used by A20 to downregulate NF-κB signalling [42]. |
T9644 | 18275-18483 | Sentence | denotes | A20 is believed to inhibit NF-κB function by deubiquitinating specific NF-κB signalling molecules, such as RIP1, RIP2, TRAF6 and MALT1, which disrupts specific protein-protein interactions [38-41] (Figure 1). |
T9643 | 17953-18274 | Sentence | denotes | A20 (also known as TNFAIP3) is a ubiquitin-editing protein that negatively regulates NF-κB-dependent gene expression in response to different immune-activating stimuli, including TNF, IL-1 and antigens, and the triggering of TLRs and the nucleotide-binding oligomerisation domain-containing 2 receptor (reviewed in [37]). |
T9642 | 17941-17952 | Sentence | denotes | A20 protein |
T8388 | 17608-17939 | Sentence | denotes | Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback regulation of the noncanonical NF-κB pathway [36], supporting the idea that IKK1 plays important roles in terminating both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA. |
T8387 | 17480-17607 | Sentence | denotes | IKK1 has also been shown to inhibit nuclear NF-κB and to downregulate proinflammatory signalling by phosphorylating STAT1 [35]. |
T8386 | 17280-17479 | Sentence | denotes | Macrophages from IKK1-deficient mice or knockin mice expressing inactive IKK1 show increased production of proinflammatory cytokines as a result of enhanced IKK2 activation and IκBα degradation [34]. |
T8385 | 16963-17279 | Sentence | denotes | These proteins are not discussed here, since a link with RA pathology has not yet been reported. Although IKK1 is a critical component of the non-canonical NF-κB pathway, it should be mentioned that this kinase also plays a prominent role in the negative regulation of both canonical and noncanonical NF-κB pathways. |
T8384 | 16785-16962 | Sentence | denotes | Several other proteins involved in the negative regulation of NF-κB-dependent inflammatory responses, such as MyD88s, IRAK-M, and TOLLIP, have been described (reviewed in [33]). |
T8383 | 16678-16784 | Sentence | denotes | In addition, we discuss the potential role of these NF-κB inhibitory factors in the immunopathology of RA. |
T8382 | 16463-16677 | Sentence | denotes | Below we give an overview of a number of proteins that are involved in the dampening or termination of the NF-κB response, some of them under the control of NF-κB itself and thus acting in a negative feedback loop. |
T8381 | 16322-16462 | Sentence | denotes | To achieve this, cells employ different mechanisms, including the expression of inhibitory proteins that downregulate NF-κB signalling [32]. |
T8380 | 16170-16321 | Sentence | denotes | Moreover, terminating an NF-κB response is essential to prevent persistent NF-κB activation that may lead to chronic inflammation and/or tumorigenesis. |
T8379 | 15962-16169 | Sentence | denotes | Since NF-κB activation is so crucial to many cellular processes, a tight regulation of the NF-κB signalling pathway and the genes it induces is an absolute requirement to fine-tune the inflammatory response. |
T4265 | 15701-15914 | Sentence | denotes | For example, in B cells TRAF6 is required for CD40-mediated JNK activation and IL-6 production, while TRAF2 is required for activation of NF-κB, and TRAF3 serves as a negative regulator of CD40 signalling [30,31]. |
T4264 | 15607-15700 | Sentence | denotes | Specific TRAF molecules are associated with overlapping and distinct CD40-mediated functions. |
T4263 | 15318-15606 | Sentence | denotes | Upon binding of their ligand, CD40 and RANK interact with several TRAF members, including TRAF1, TRAF2, TRAF3, TRAF5, and TRAF6, and this leads to the proteolysis of both TRAF2 and TRAF3, which represents an important step in the activation of the noncanonical pathway as described above. |
T4262 | 15167-15317 | Sentence | denotes | It should be mentioned that CD40, lymphotoxin β receptor and RANK mediate the activation of both canonical and noncanonical NF-κB signalling pathways. |
T4261 | 13691-13838 | Sentence | denotes | All this contributes to releasing NIK from its constitutive degradation, resulting in NIK accumulation and IKK1 phosphorylation [28,29] (Figure 2). |
T4260 | 13488-13690 | Sentence | denotes | Receptor ligation has been shown not only to remove TRAF3 from this complex by recruiting it to the receptor, but also to attract TRAF2 and cIAP1/2, which are essential for subsequent TRAF3 degradation. |
T4259 | 13307-13487 | Sentence | denotes | In unstimulated cells, NIK occurs in a cytoplasmic complex with TRAF2, TRAF3, and cIAP1/2, which K48-polyubiquitinates NIK, leading to its continuous degradation by the proteasome. |
T4258 | 13185-13306 | Sentence | denotes | NIK is predominantly regulated at the post-translational level and is present at extremely low levels in most cell types. |
T4257 | 12807-13184 | Sentence | denotes | In this pathway, p100 is processed by the proteasome to p52, which together with the RelB NF-κB subunit regulates a distinct set of target genes that control B-cell development, secondary lymphoid organ development, and osteoclastogenesis [27] The noncanonical NF-κB pathway is strictly dependent on IKK1, which is activated upon phosphorylation by NF-κB inducing kinase (NIK). |
T4256 | 12686-12806 | Sentence | denotes | The noncanonical NF-κB pathway can be activated by the lymphotoxin β receptor, BAFF receptor, CD40, and RANK (Figure 2). |
T4255 | 12569-12685 | Sentence | denotes | Both pathways then activate TAK1 and IKK in a ubiquitination-dependent manner similar to the TNF pathway (Figure 1). |
T4254 | 12499-12568 | Sentence | denotes | TRIF also recruits TRAF6 [25] and RIP1 [26] via a direct interaction. |
T4253 | 12347-12498 | Sentence | denotes | MyD88 in turn recruits members of the IL-1R-associated kinase (IRAK) family and TRAF6, leading to oligomerisation and selfubiquitination of TRAF6 [24]. |
T4252 | 11981-12346 | Sentence | denotes | For example, TLR4 stimulation by lipopolysaccharide induces the recruitment of Toll/IL-1 receptor adaptor protein (also referred to as Mal) and TRIF-related adaptor molecule (TRAM), which most probably serve as bridging factors to recruit myeloid differentiation primary response gene 88 (MyD88) and TIR domain-containing adaptor-inducing IFNβ (TRIF), respectively. |
T4251 | 11925-11980 | Sentence | denotes | Similar signalling principles apply to other receptors. |
T4250 | 11741-11924 | Sentence | denotes | The exact role of protein-anchored polyubiquitin chains remains unclear, as it was recently suggested that unanchored polyubiquitin chains can directly activate the TAK1 complex [23]. |
T4249 | 11546-11740 | Sentence | denotes | The recent identification of a distinct E2/E3 enzyme complex that modifies NEMO with linear polyubiquitin chains and is essential for TNF-activated NF-κB signalling adds further complexity [22]. |
T4248 | 11377-11545 | Sentence | denotes | The polyubiquitin chains on RIP1 are believed to create a scaffold to recruit the IKK and TAK1 complex via the ubiquitin-binding proteins NEMO and TAB1/2, respectively. |
T4247 | 11264-11376 | Sentence | denotes | TRAF2/5 and cIAP1/2 are good candidates for RIP1 ubiquitination, but the specific role of each is still unclear. |
T4246 | 11164-11263 | Sentence | denotes | On TNF stimulation, TNF-receptor bound RIP1 is rapidly modified by K63-linked polyubiquitin chains. |
T4245 | 10795-11163 | Sentence | denotes | TNF stimulation results in the recruitment of TNF receptor-1-associated death domain (TRADD) protein and of receptor interacting protein 1 (RIP1), which function as adaptor proteins for the E3 ubiquitin ligases TNF receptor-associated factor (TRAF) 2 and TRAF5, which in turn bind the E3 ubiquitin ligases cellular inhibitor of apoptosis (cIAP) 1 and cIAP2 (Figure 1). |
T4244 | 10725-10794 | Sentence | denotes | One of the best studied NF-κB signalling pathways is the TNF pathway. |
T4243 | 8412-8529 | Sentence | denotes | Gene targeting experiments showed that IKK2 and NEMO, but not IKK1, are required for canonical NF-κB activation [21]. |
T4242 | 8216-8411 | Sentence | denotes | The IKK complex is comprised of the two catalytic subunits IKK1 and IKK2 (also known as IKKα and IKKβ) and the regulatory subunit NF-κB essential modulator (NEMO - also known as IKKγ) (Figure 1). |
T4241 | 7854-8215 | Sentence | denotes | NF-κB signalling initiated by different receptors requires the formation of proximal protein-protein interactions that are often receptor specific, but ultimately converge in the activation of the IκB kinase (IKK) complex, which mediates phosphorylation of the inhibitory IκB protein leading to its K48-polyubiquitination and degradation by the proteasome [20]. |
T1758 | 3644-3902 | Sentence | denotes | NF-κB activation by receptor activator of NF-κB (RANK), a TNF receptor family member, is important for osteoclastogenesis, and defects in proper RANK-NF-κB signalling are likely to be involved in RA pathology and other diseases associated with bone loss [7]. |
T1757 | 3450-3643 | Sentence | denotes | TNF and IL-1 are both very potent activators of NF-κB and it can be expected that NF-κB activation by these cytokines mediates most of their pro-inflammatory activities in RA (reviewed in [3]). |
T1756 | 3257-3449 | Sentence | denotes | It is well accepted that proinflammatory cytokines such as TNF and IL-1 play an important role, and administration of TNF antagonists is an effective treatment for severe RA (reviewed in [9]). |
T1755 | 3099-3256 | Sentence | denotes | Since NF-κB is central to the process of inflammation in RA, much research deals with the identification of the molecular triggers that activate NF-κB in RA. |
T4240 | 7645-7853 | Sentence | denotes | The canonical NF-κB pathway plays a major role in innate and adaptive immunity, and is triggered by many stimuli including proinflammatory cytokines (for example, TNF, IL-1), antigens, RANKL, and TLR ligands. |
T4239 | 7515-7644 | Sentence | denotes | There are two unique NF-κB signalling pathways, termed canonical (or classical) and noncanonical (or alternative) NF-κB pathways. |
T4238 | 7229-7514 | Sentence | denotes | Whereas the majority of IκBs (IκBα, IκBβ, IκBε, p105 (also known as NF-κB1), p100 (also known as NF-κB2)) serve as inhibitors of NF-κB, IκBξ and Bcl-3 instead potentiate NF-κB transactivation in the nucleus. p100 and p105 are precursors of the p52 and p50 NF-κB subunits, respectively. |
T4237 | 7024-7228 | Sentence | denotes | NF-κB proteins are sequestered in the cytoplasm as latent complexes by inhibitory proteins referred to as inhibitor of NF-κB (IκB) proteins, which prevent NF-κB nuclear translocation and DNA binding [19]. |
T335 | 2821-3049 | Sentence | denotes | Finally, recent discoveries revealing a genetic association with several genes relevant to NF-κB signalling, including CD40, TRAF1, TNFAIP3, and c-REL, further highlight the importance of NF-κB activation in RA pathogenesis [8]. |
T334 | 2698-2820 | Sentence | denotes | Defects in the regulation of osteoclastogenesis are the major cause of bone erosion in osteolytic diseases such as RA [7]. |
T333 | 2518-2697 | Sentence | denotes | Next to its role in proinflammatory gene expression, NF-κB is also essential for osteoclastogenesis, mainly by mediating the effects of receptor activator of NF-κB ligand (RANKL). |
T332 | 2366-2517 | Sentence | denotes | The time course of NF-κB activation appears to precede the onset of disease, and blockade of NF-κB by different means decreases disease severity [5,6]. |
T331 | 2116-2365 | Sentence | denotes | NF-κB activation can be detected in cultured synovial fibroblasts and synovial tissue from RA patients, and animal models of inflammatory arthritis also demonstrate the active role of NF-κB in the development and progression of RA (reviewed in [4]). |
T330 | 2022-2115 | Sentence | denotes | In addition, TNF and IL-1 are themselves very potent activators of NF-κB (reviewed in [2,3]). |
T329 | 1618-2021 | Sentence | denotes | NF-κB represents a family of structurally related and evolutionarily conserved proteins (p100 or NF-κB2, p105 or NF-κB1, p65 or RelA, RelB, c-Rel) that function as homodimers or heterodimers [1], and that regulate the expression of a large number of genes - such as TNF, IL-1, IL-6, cyclo-oxygenase-2, chemokines, inducible nitric oxide synthase, and matrix metalloproteinases - that are involved in RA. |
T328 | 1420-1617 | Sentence | denotes | The aetiology of RA is still not understood, but it is well accepted that activation of NF-κB-dependent gene expression plays a key role in the development of RA and many other autoimmune diseases. |
T327 | 1272-1419 | Sentence | denotes | Proliferation of synovial fibroblasts leads to the formation of pannus tissue, which invades and degrades articular cartilage and subchondral bone. |
T326 | 1005-1271 | Sentence | denotes | Infiltration of cells of the innate and adaptive immune system into the joint space drives the local production of proinflammatory T-helper type 1 and T-helper type 17 cytokines, chemokines, and matrix metalloproteinases by infiltrating monocytes and synovial cells. |
T325 | 800-1004 | Sentence | denotes | RA is characterised by a symmetrical polyarthritis in which chronic inflammation of joints is associated with a progressive destruction of cartilage and bone, leading to functional decline and disability. |
T324 | 687-799 | Sentence | denotes | Rheumatoid arthritis (RA) is the most common inflammatory arthritis, affecting up to 1% of the adult population. |
T18902 | 33402-33651 | Sentence | denotes | How all these regulatory signals are themselves regulated will be an important question in order to clarify how NF-κB signalling is organised, and, more importantly, how this knowledge may lead to new treatments for inflammatory diseases such as RA. |
T18901 | 33280-33401 | Sentence | denotes | In addition, given the number of miRNAs in humans and the multiple mRNAs they target, intense complexity can be expected. |
T18900 | 33071-33279 | Sentence | denotes | The existence of multiple negative regulators ensuring a tight regulation of the NF-κB pathway, however, raises the question of the specific role of each of these regulators and the relationship between them. |
T18899 | 32964-33070 | Sentence | denotes | Keeping NF-κB activation under control can thus be very important for the design of specific therapeutics. |
T18898 | 32823-32963 | Sentence | denotes | The NF-κB family of transcription factors plays crucial roles in the inflammatory processes in RA leading to cartilage and bone destruction. |
T1772 | 6825-6985 | Sentence | denotes | Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA. |
T1771 | 6614-6824 | Sentence | denotes | Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). |
T1770 | 6311-6613 | Sentence | denotes | Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. |
T1769 | 6138-6310 | Sentence | denotes | HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. |
T1768 | 5880-6137 | Sentence | denotes | High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. |
T1767 | 5695-5879 | Sentence | denotes | Moreover, animal models using TLR knockout mice or strategies to block TLR signalling clearly identify TLR-dependent inflammation as being important in the pathogenesis of the disease. |
T1766 | 5567-5694 | Sentence | denotes | TLRs are expressed in RA synovial tissues and various endogenous ligands are present within the inflamed joints of RA patients. |
T1765 | 5316-5566 | Sentence | denotes | In addition to microbial ligands, an increasing number of endogenous ligands - a group of proteins derived from host tissues and cells - have been reported as candidate activators of TLRs inducing so-called sterile inflammation (reviewed in [14,15]). |
T1764 | 5154-5315 | Sentence | denotes | Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases and are potential candidates for inducing NF-κB-dependent inflammation in RA. |
T1763 | 5002-5153 | Sentence | denotes | Finally, lymphotoxin β receptor signalling has been implicated in tertiary lymphoid organ formation at sites of chronic inflammation including RA [13]. |
T1762 | 4756-5001 | Sentence | denotes | Enhanced expression of the TNF receptor family member B-cell activating factor (BAFF), allowing the survival of autoantibody- producing B lymphocytes, is also characteristic for RA, and antagonists of BAFF have been developed to counter RA [13]. |
T1761 | 4479-4755 | Sentence | denotes | However, studies with antagonistic anti-CD40 or anti-CD154 antibodies led to the conclusion that CD40 signals may be important at the initial stages of arthritis induction, but are not required once disease is established and pathogenic antibodies are already present [11,12]. |
T1760 | 4207-4478 | Sentence | denotes | Binding of the CD40 ligand (CD154), which is transiently expressed on the surface of activated CD4+ T cells, triggers NF-κB activation resulting in fibroblast proliferation and secretion of proinflammatory cytokines and chemokines, which contributes to joint destruction. |
T1759 | 3903-4206 | Sentence | denotes | CD40 is another TNF receptor family member that is functionally expressed on a variety of cell types, including smooth muscle fibroblasts from normal and RA patients and RA synovial cells, B cells, macrophages, and dendritic cells, and can be upregulated by proinflammatory cytokines including TNF [10]. |
T1 | 0-72 | Sentence | denotes | Negative regulation of NF-κB and its involvement in rheumatoid arthritis |
T2 | 83-317 | Sentence | denotes | The transcription factor NF-κB plays crucial roles in the regulation of inflammation and mmune responses, and inappropriate NF-κB activity has been linked with many autoimmune and inflammatory diseases, including rheumatoid arthritis. |
T3 | 318-491 | Sentence | denotes | Cells employ a multilayered control system to keep NF-κB signalling in check, including a repertoire of negative feedback regulators ensuring termination of NF-κB responses. |
T4 | 492-672 | Sentence | denotes | Here we will review various negative regulatory mechanisms that have evolved to control NF-κB signalling and which have been implicated in the pathogenesis of rheumatoid arthritis. |
T1 | 0-72 | Sentence | denotes | Negative regulation of NF-κB and its involvement in rheumatoid arthritis |
T2 | 74-82 | Sentence | denotes | Abstract |
T3 | 83-317 | Sentence | denotes | The transcription factor NF-κB plays crucial roles in the regulation of inflammation and mmune responses, and inappropriate NF-κB activity has been linked with many autoimmune and inflammatory diseases, including rheumatoid arthritis. |
T4 | 318-491 | Sentence | denotes | Cells employ a multilayered control system to keep NF-κB signalling in check, including a repertoire of negative feedback regulators ensuring termination of NF-κB responses. |
T5 | 492-672 | Sentence | denotes | Here we will review various negative regulatory mechanisms that have evolved to control NF-κB signalling and which have been implicated in the pathogenesis of rheumatoid arthritis. |
T6 | 674-686 | Sentence | denotes | Introduction |
T7 | 687-799 | Sentence | denotes | Rheumatoid arthritis (RA) is the most common inflammatory arthritis, affecting up to 1% of the adult population. |
T8 | 800-1004 | Sentence | denotes | RA is characterised by a symmetrical polyarthritis in which chronic inflammation of joints is associated with a progressive destruction of cartilage and bone, leading to functional decline and disability. |
T9 | 1005-1271 | Sentence | denotes | Infiltration of cells of the innate and adaptive immune system into the joint space drives the local production of proinflammatory T-helper type 1 and T-helper type 17 cytokines, chemokines, and matrix metalloproteinases by infiltrating monocytes and synovial cells. |
T10 | 1272-1419 | Sentence | denotes | Proliferation of synovial fibroblasts leads to the formation of pannus tissue, which invades and degrades articular cartilage and subchondral bone. |
T11 | 1420-1617 | Sentence | denotes | The aetiology of RA is still not understood, but it is well accepted that activation of NF-κB-dependent gene expression plays a key role in the development of RA and many other autoimmune diseases. |
T12 | 1618-2021 | Sentence | denotes | NF-κB represents a family of structurally related and evolutionarily conserved proteins (p100 or NF-κB2, p105 or NF-κB1, p65 or RelA, RelB, c-Rel) that function as homodimers or heterodimers [1], and that regulate the expression of a large number of genes - such as TNF, IL-1, IL-6, cyclo-oxygenase-2, chemokines, inducible nitric oxide synthase, and matrix metalloproteinases - that are involved in RA. |
T13 | 2022-2115 | Sentence | denotes | In addition, TNF and IL-1 are themselves very potent activators of NF-κB (reviewed in [2,3]). |
T14 | 2116-2365 | Sentence | denotes | NF-κB activation can be detected in cultured synovial fibroblasts and synovial tissue from RA patients, and animal models of inflammatory arthritis also demonstrate the active role of NF-κB in the development and progression of RA (reviewed in [4]). |
T15 | 2366-2517 | Sentence | denotes | The time course of NF-κB activation appears to precede the onset of disease, and blockade of NF-κB by different means decreases disease severity [5,6]. |
T16 | 2518-2697 | Sentence | denotes | Next to its role in proinflammatory gene expression, NF-κB is also essential for osteoclastogenesis, mainly by mediating the effects of receptor activator of NF-κB ligand (RANKL). |
T17 | 2698-2820 | Sentence | denotes | Defects in the regulation of osteoclastogenesis are the major cause of bone erosion in osteolytic diseases such as RA [7]. |
T18 | 2821-3049 | Sentence | denotes | Finally, recent discoveries revealing a genetic association with several genes relevant to NF-κB signalling, including CD40, TRAF1, TNFAIP3, and c-REL, further highlight the importance of NF-κB activation in RA pathogenesis [8]. |
T19 | 3051-3098 | Sentence | denotes | Pathological triggers of NF-κB signalling in RA |
T20 | 3099-3256 | Sentence | denotes | Since NF-κB is central to the process of inflammation in RA, much research deals with the identification of the molecular triggers that activate NF-κB in RA. |
T21 | 3257-3449 | Sentence | denotes | It is well accepted that proinflammatory cytokines such as TNF and IL-1 play an important role, and administration of TNF antagonists is an effective treatment for severe RA (reviewed in [9]). |
T22 | 3450-3643 | Sentence | denotes | TNF and IL-1 are both very potent activators of NF-κB and it can be expected that NF-κB activation by these cytokines mediates most of their pro-inflammatory activities in RA (reviewed in [3]). |
T23 | 3644-3902 | Sentence | denotes | NF-κB activation by receptor activator of NF-κB (RANK), a TNF receptor family member, is important for osteoclastogenesis, and defects in proper RANK-NF-κB signalling are likely to be involved in RA pathology and other diseases associated with bone loss [7]. |
T24 | 3903-4206 | Sentence | denotes | CD40 is another TNF receptor family member that is functionally expressed on a variety of cell types, including smooth muscle fibroblasts from normal and RA patients and RA synovial cells, B cells, macrophages, and dendritic cells, and can be upregulated by proinflammatory cytokines including TNF [10]. |
T25 | 4207-4478 | Sentence | denotes | Binding of the CD40 ligand (CD154), which is transiently expressed on the surface of activated CD4+ T cells, triggers NF-κB activation resulting in fibroblast proliferation and secretion of proinflammatory cytokines and chemokines, which contributes to joint destruction. |
T26 | 4479-4755 | Sentence | denotes | However, studies with antagonistic anti-CD40 or anti-CD154 antibodies led to the conclusion that CD40 signals may be important at the initial stages of arthritis induction, but are not required once disease is established and pathogenic antibodies are already present [11,12]. |
T27 | 4756-5001 | Sentence | denotes | Enhanced expression of the TNF receptor family member B-cell activating factor (BAFF), allowing the survival of autoantibody- producing B lymphocytes, is also characteristic for RA, and antagonists of BAFF have been developed to counter RA [13]. |
T28 | 5002-5153 | Sentence | denotes | Finally, lymphotoxin β receptor signalling has been implicated in tertiary lymphoid organ formation at sites of chronic inflammation including RA [13]. |
T29 | 5154-5315 | Sentence | denotes | Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases and are potential candidates for inducing NF-κB-dependent inflammation in RA. |
T30 | 5316-5566 | Sentence | denotes | In addition to microbial ligands, an increasing number of endogenous ligands - a group of proteins derived from host tissues and cells - have been reported as candidate activators of TLRs inducing so-called sterile inflammation (reviewed in [14,15]). |
T31 | 5567-5694 | Sentence | denotes | TLRs are expressed in RA synovial tissues and various endogenous ligands are present within the inflamed joints of RA patients. |
T32 | 5695-5879 | Sentence | denotes | Moreover, animal models using TLR knockout mice or strategies to block TLR signalling clearly identify TLR-dependent inflammation as being important in the pathogenesis of the disease. |
T33 | 5880-6137 | Sentence | denotes | High mobility group box chromosomal protein 1 (HMGB1), a highly conserved chromatin component that can be actively secreted by macrophages or passively released by necrotic cells, is one of the most putative endogenous TLR4 ligands involved in RA pathology. |
T34 | 6138-6310 | Sentence | denotes | HMGB1 is increased in RA synovial tissue and HMGB1 neutralising antibodies or the antagonistic BoxA domain of HMGB1 protect against collagen-induced arthritis in mice [16]. |
T35 | 6311-6613 | Sentence | denotes | Myeloid-related protein 8 and myeloid-related protein 14, damage-associated molecular pattern molecules belonging to the S100 family of calcium-binding proteins, are also abundantly present in RA synovial fluid, and have been suggested to be involved in TLR4-induced chronic inflammation in RA [17,18]. |
T36 | 6614-6824 | Sentence | denotes | Other endogenous TLR ligands that may be involved in RA pathology are extracellular matrix components such as fibrinogen, fibronectin, biglycan, tenascin C, and hyal-uronic acid fragments (reviewed in [14,15]). |
T37 | 6825-6985 | Sentence | denotes | Together, these studies suggest that several TLR ligands in the inflamed joint tissue may contribute to NF-κB activation and inflammatory gene expression in RA. |
T38 | 6987-7023 | Sentence | denotes | Basic principles of NF-κB signalling |
T39 | 7024-7228 | Sentence | denotes | NF-κB proteins are sequestered in the cytoplasm as latent complexes by inhibitory proteins referred to as inhibitor of NF-κB (IκB) proteins, which prevent NF-κB nuclear translocation and DNA binding [19]. |
T40 | 7229-7514 | Sentence | denotes | Whereas the majority of IκBs (IκBα, IκBβ, IκBε, p105 (also known as NF-κB1), p100 (also known as NF-κB2)) serve as inhibitors of NF-κB, IκBξ and Bcl-3 instead potentiate NF-κB transactivation in the nucleus. p100 and p105 are precursors of the p52 and p50 NF-κB subunits, respectively. |
T41 | 7515-7644 | Sentence | denotes | There are two unique NF-κB signalling pathways, termed canonical (or classical) and noncanonical (or alternative) NF-κB pathways. |
T42 | 7645-7853 | Sentence | denotes | The canonical NF-κB pathway plays a major role in innate and adaptive immunity, and is triggered by many stimuli including proinflammatory cytokines (for example, TNF, IL-1), antigens, RANKL, and TLR ligands. |
T43 | 7854-8215 | Sentence | denotes | NF-κB signalling initiated by different receptors requires the formation of proximal protein-protein interactions that are often receptor specific, but ultimately converge in the activation of the IκB kinase (IKK) complex, which mediates phosphorylation of the inhibitory IκB protein leading to its K48-polyubiquitination and degradation by the proteasome [20]. |
T44 | 8216-8411 | Sentence | denotes | The IKK complex is comprised of the two catalytic subunits IKK1 and IKK2 (also known as IKKα and IKKβ) and the regulatory subunit NF-κB essential modulator (NEMO - also known as IKKγ) (Figure 1). |
T45 | 8412-8529 | Sentence | denotes | Gene targeting experiments showed that IKK2 and NEMO, but not IKK1, are required for canonical NF-κB activation [21]. |
T46 | 8530-8591 | Sentence | denotes | Figure 1 Canonical NF-κB signalling and negative regulators. |
T47 | 8592-8949 | Sentence | denotes | Ligand engagement of specific membrane receptors such as TNFR1, CD40, RANK, and TLR4 trigger the recruitment of specific adaptor proteins (TNF receptor 1-associated death domain protein (TRADD), MyD88, MAL, TIR domain-containing adaptor-inducing IFNβ (TRIF)), kinases (RIP1, IRAK1, IRAK4), and ubiquitin ligases (TRAF2, TRAF6, cIAP1, cIAP2) to the receptor. |
T48 | 8950-9120 | Sentence | denotes | K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1, is recognised by NEMO and TAB proteins, resulting in the recruitment and activation of respectively IKK2 and TAK1. |
T49 | 9121-9270 | Sentence | denotes | TAK1 then phosphorylates and activates IKK2, which in turn phosphorylates IκBα, triggering its K48-linked ubiquitination and proteasomal degradation. |
T50 | 9271-9399 | Sentence | denotes | This allows NF-κB (here shown as a heterodimer of p65 and p50) to translocate to the nucleus and promote target gene expression. |
T51 | 9400-9533 | Sentence | denotes | TRAF1, which has no ubiquitin ligase activity, can negatively regulate NF-κB activation, most probably by competing with other TRAFs. |
T52 | 9534-9877 | Sentence | denotes | A20 and CYLD are deubiquitinating enzymes that control NF-κB activation by targeting specific signalling proteins including RIP1 and TRAF6, to which they are recruited using specific ubiquitin-binding adaptor proteins such as ABIN-1 and p62. miR-146 is thought to negatively regulate TLR signalling by inhibiting expression of IRAK1 and TRAF6. |
T53 | 9878-10037 | Sentence | denotes | Finally, TLR signalling can also be inhibited by the transmembrane protein SIGIRR, which has been proposed to compete with TLR4 for binding to IRAK1 and TRAF6. |
T54 | 10038-10193 | Sentence | denotes | The expression of many of these negative regulatory molecules is NF-κB dependent, implicating them in the negative feedback regulation of NF-κB activation. |
T55 | 10194-10724 | Sentence | denotes | ABIN, A20-binding inhibitor of NF-κB; cIAP, cellular inhibitor of apoptosis; CYLD, cylindromatosis; IKK, IκB kinase; IκB, inhibitor of NF-κB; IRAK, IL-1R-associated kinase; MyD88, myeloid differentiation primary response gene 88; NEMO, NF-κB essential modulator; NF, nuclear factor; RANK, receptor activator of NF-κB; RIP1, receptor interacting protein 1; SIGIRR, single-immunoglobulinIL-1 receptor-related; TIR, Toll-like receptor/IL-1R; TRAF, TNF receptor-associated factor; TLR, Toll-like receptor; TNF, tumour necrosis factor. |
T56 | 10725-10794 | Sentence | denotes | One of the best studied NF-κB signalling pathways is the TNF pathway. |
T57 | 10795-11163 | Sentence | denotes | TNF stimulation results in the recruitment of TNF receptor-1-associated death domain (TRADD) protein and of receptor interacting protein 1 (RIP1), which function as adaptor proteins for the E3 ubiquitin ligases TNF receptor-associated factor (TRAF) 2 and TRAF5, which in turn bind the E3 ubiquitin ligases cellular inhibitor of apoptosis (cIAP) 1 and cIAP2 (Figure 1). |
T58 | 11164-11263 | Sentence | denotes | On TNF stimulation, TNF-receptor bound RIP1 is rapidly modified by K63-linked polyubiquitin chains. |
T59 | 11264-11376 | Sentence | denotes | TRAF2/5 and cIAP1/2 are good candidates for RIP1 ubiquitination, but the specific role of each is still unclear. |
T60 | 11377-11545 | Sentence | denotes | The polyubiquitin chains on RIP1 are believed to create a scaffold to recruit the IKK and TAK1 complex via the ubiquitin-binding proteins NEMO and TAB1/2, respectively. |
T61 | 11546-11740 | Sentence | denotes | The recent identification of a distinct E2/E3 enzyme complex that modifies NEMO with linear polyubiquitin chains and is essential for TNF-activated NF-κB signalling adds further complexity [22]. |
T62 | 11741-11924 | Sentence | denotes | The exact role of protein-anchored polyubiquitin chains remains unclear, as it was recently suggested that unanchored polyubiquitin chains can directly activate the TAK1 complex [23]. |
T63 | 11925-11980 | Sentence | denotes | Similar signalling principles apply to other receptors. |
T64 | 11981-12346 | Sentence | denotes | For example, TLR4 stimulation by lipopolysaccharide induces the recruitment of Toll/IL-1 receptor adaptor protein (also referred to as Mal) and TRIF-related adaptor molecule (TRAM), which most probably serve as bridging factors to recruit myeloid differentiation primary response gene 88 (MyD88) and TIR domain-containing adaptor-inducing IFNβ (TRIF), respectively. |
T65 | 12347-12498 | Sentence | denotes | MyD88 in turn recruits members of the IL-1R-associated kinase (IRAK) family and TRAF6, leading to oligomerisation and selfubiquitination of TRAF6 [24]. |
T66 | 12499-12568 | Sentence | denotes | TRIF also recruits TRAF6 [25] and RIP1 [26] via a direct interaction. |
T67 | 12569-12685 | Sentence | denotes | Both pathways then activate TAK1 and IKK in a ubiquitination-dependent manner similar to the TNF pathway (Figure 1). |
T68 | 12686-12806 | Sentence | denotes | The noncanonical NF-κB pathway can be activated by the lymphotoxin β receptor, BAFF receptor, CD40, and RANK (Figure 2). |
T69 | 12807-13184 | Sentence | denotes | In this pathway, p100 is processed by the proteasome to p52, which together with the RelB NF-κB subunit regulates a distinct set of target genes that control B-cell development, secondary lymphoid organ development, and osteoclastogenesis [27] The noncanonical NF-κB pathway is strictly dependent on IKK1, which is activated upon phosphorylation by NF-κB inducing kinase (NIK). |
T70 | 13185-13306 | Sentence | denotes | NIK is predominantly regulated at the post-translational level and is present at extremely low levels in most cell types. |
T71 | 13307-13487 | Sentence | denotes | In unstimulated cells, NIK occurs in a cytoplasmic complex with TRAF2, TRAF3, and cIAP1/2, which K48-polyubiquitinates NIK, leading to its continuous degradation by the proteasome. |
T72 | 13488-13690 | Sentence | denotes | Receptor ligation has been shown not only to remove TRAF3 from this complex by recruiting it to the receptor, but also to attract TRAF2 and cIAP1/2, which are essential for subsequent TRAF3 degradation. |
T73 | 13691-13838 | Sentence | denotes | All this contributes to releasing NIK from its constitutive degradation, resulting in NIK accumulation and IKK1 phosphorylation [28,29] (Figure 2). |
T74 | 13839-13879 | Sentence | denotes | Figure 2 Noncanonical NF-κB signalling. |
T75 | 13880-14005 | Sentence | denotes | CD40 and RANK can activate the noncanonical NF-κB pathway that is dependent on NF-κB inducing kinase (NIK) expression levels. |
T76 | 14006-14222 | Sentence | denotes | In unstimulated cells NIK forms a cytosolic complex with the ubiquitin ligases TRAF2, TRAF3 and cIAP1/2, which facilitates the K48-linked polyubiquitination and proteasomal degradation of NIK, keeping NIK levels low. |
T77 | 14223-14387 | Sentence | denotes | Upon ligand binding, TRAF3 is recruited to the receptor, where TRAF2 directs nondegradative K63-linked polyubiquitination of cIAP1/2, resulting in their activation. |
T78 | 14388-14477 | Sentence | denotes | Subsequently cIAP1/2 directs its K48-linked polyubiquitination to TRAF3, rather than NIK. |
T79 | 14478-14578 | Sentence | denotes | As a result, TRAF3 is degraded and NIK is stabilised, resulting in increased NIK levels in the cell. |
T80 | 14579-14665 | Sentence | denotes | NIK then phosphorylates and activates IKK1, which mediates NF-κB p100 phosphorylation. |
T81 | 14666-14830 | Sentence | denotes | This is followed by K48-linked polyubiquitination and partial proteasomal degradation of p100 to p52, which forms a heterodimer with RelB to activate transcription. |
T82 | 14831-15166 | Sentence | denotes | Next to TRAF3, TRAF1 has also been identified as a negative regulator of this pathway, most probably by competing with other TNF receptor-associated factors. cIAP, cellular inhibitor of apoptosis; IKK, IκB kinase; NF, nuclear factor; RANK, receptor activator of NF-κB; TRAF, TNF receptor-associated factor; TNF, tumour necrosis factor. |
T83 | 15167-15317 | Sentence | denotes | It should be mentioned that CD40, lymphotoxin β receptor and RANK mediate the activation of both canonical and noncanonical NF-κB signalling pathways. |
T84 | 15318-15606 | Sentence | denotes | Upon binding of their ligand, CD40 and RANK interact with several TRAF members, including TRAF1, TRAF2, TRAF3, TRAF5, and TRAF6, and this leads to the proteolysis of both TRAF2 and TRAF3, which represents an important step in the activation of the noncanonical pathway as described above. |
T85 | 15607-15700 | Sentence | denotes | Specific TRAF molecules are associated with overlapping and distinct CD40-mediated functions. |
T86 | 15701-15914 | Sentence | denotes | For example, in B cells TRAF6 is required for CD40-mediated JNK activation and IL-6 production, while TRAF2 is required for activation of NF-κB, and TRAF3 serves as a negative regulator of CD40 signalling [30,31]. |
T87 | 15916-15961 | Sentence | denotes | Negative regulation of NF-κB signalling in RA |
T88 | 15962-16169 | Sentence | denotes | Since NF-κB activation is so crucial to many cellular processes, a tight regulation of the NF-κB signalling pathway and the genes it induces is an absolute requirement to fine-tune the inflammatory response. |
T89 | 16170-16321 | Sentence | denotes | Moreover, terminating an NF-κB response is essential to prevent persistent NF-κB activation that may lead to chronic inflammation and/or tumorigenesis. |
T90 | 16322-16462 | Sentence | denotes | To achieve this, cells employ different mechanisms, including the expression of inhibitory proteins that downregulate NF-κB signalling [32]. |
T91 | 16463-16677 | Sentence | denotes | Below we give an overview of a number of proteins that are involved in the dampening or termination of the NF-κB response, some of them under the control of NF-κB itself and thus acting in a negative feedback loop. |
T92 | 16678-16784 | Sentence | denotes | In addition, we discuss the potential role of these NF-κB inhibitory factors in the immunopathology of RA. |
T93 | 16785-16962 | Sentence | denotes | Several other proteins involved in the negative regulation of NF-κB-dependent inflammatory responses, such as MyD88s, IRAK-M, and TOLLIP, have been described (reviewed in [33]). |
T94 | 16963-17059 | Sentence | denotes | These proteins are not discussed here, since a link with RA pathology has not yet been reported. |
T95 | 17060-17279 | Sentence | denotes | Although IKK1 is a critical component of the non-canonical NF-κB pathway, it should be mentioned that this kinase also plays a prominent role in the negative regulation of both canonical and noncanonical NF-κB pathways. |
T96 | 17280-17479 | Sentence | denotes | Macrophages from IKK1-deficient mice or knockin mice expressing inactive IKK1 show increased production of proinflammatory cytokines as a result of enhanced IKK2 activation and IκBα degradation [34]. |
T97 | 17480-17607 | Sentence | denotes | IKK1 has also been shown to inhibit nuclear NF-κB and to downregulate proinflammatory signalling by phosphorylating STAT1 [35]. |
T98 | 17608-17939 | Sentence | denotes | Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback regulation of the noncanonical NF-κB pathway [36], supporting the idea that IKK1 plays important roles in terminating both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA. |
T99 | 17941-17952 | Sentence | denotes | A20 protein |
T100 | 17953-18274 | Sentence | denotes | A20 (also known as TNFAIP3) is a ubiquitin-editing protein that negatively regulates NF-κB-dependent gene expression in response to different immune-activating stimuli, including TNF, IL-1 and antigens, and the triggering of TLRs and the nucleotide-binding oligomerisation domain-containing 2 receptor (reviewed in [37]). |
T101 | 18275-18483 | Sentence | denotes | A20 is believed to inhibit NF-κB function by deubiquitinating specific NF-κB signalling molecules, such as RIP1, RIP2, TRAF6 and MALT1, which disrupts specific protein-protein interactions [38-41] (Figure 1). |
T102 | 18484-18733 | Sentence | denotes | Recently, the disruption of interactions between E2 ubiquitin conjugating enzymes (Ubc13 and Ubc5hc) and E3 ubiquitin ligases (TRAF6, TRAF2 and cIAP1/2) were described as another important mechanism used by A20 to downregulate NF-κB signalling [42]. |
T103 | 18734-18913 | Sentence | denotes | The association of A20 with its targets requires specific ubiquitin-binding adaptor proteins, including A20-binding inhibitor of NF-κB (ABIN) 1 and Tax1-binding protein 1 [43-46]. |
T104 | 18914-19037 | Sentence | denotes | Next to its role in suppressing NF-κB activation, A20 is also a strong inhibitor of apoptosis, at least in some cell types. |
T105 | 19038-19125 | Sentence | denotes | The mechanisms by which A20 regulates apoptotic signalling, however, are still elusive. |
T106 | 19126-19310 | Sentence | denotes | A20-deficient mice spontaneously develop multiorgan inflammation and cachexia and die within 2 weeks of birth, illustrating the potent anti-inflammatory function of this molecule [46]. |
T107 | 19311-19432 | Sentence | denotes | A20-deficient cells are also more susceptible to TNF-mediated apoptosis, confirming its role as an antiapoptotic protein. |
T108 | 19433-19748 | Sentence | denotes | We recently showed that mice specifically lacking A20 in intestinal epithelial cells exhibit increased susceptibility to experimental colitis due to the hypersensitivity of their intestinal epithelial cells to TNF-induced apoptosis, confirming A20 as a major antiapoptotic protein in the intestinal epithelium [47]. |
T109 | 19749-19928 | Sentence | denotes | Two independent studies showed that mice lacking A20 in B cells develop autoimmunity due to hyperactive NF-κB responses in B cells leading to unrestricted B-cell survival [48,49]. |
T110 | 19929-20090 | Sentence | denotes | A20 expression has been observed in several cell types that play important roles in the pathophysiology of RA, such as fibroblasts, synoviocytes and lymphocytes. |
T111 | 20091-20228 | Sentence | denotes | Interestingly, A20 expression is itself regulated by NF-κB [50], implicating A20 in the negative feedback regulation of NF-κB signalling. |
T112 | 20229-20498 | Sentence | denotes | Recently, intra-articular injection of an A20-expressing adenovirus was shown to reduce the severity of synovial inflammation and joint destruction in a mouse model of collagen-induced arthritis, even in untreated joints, in both a prophylactic and therapeutic setting. |
T113 | 20499-20852 | Sentence | denotes | A20 expression in synovial tissue was associated with inhibition of NF-κB activity and decreased levels of TNF, IL-1β, IL-6, soluble RANKL, monocyte chemo-attractant protein 1, and IL-17, suggesting that A20 induces a protective effect in collagen-induced arthritis mice through suppression of NF-κB activation and NF- κB-dependent gene expression [51]. |
T114 | 20853-21127 | Sentence | denotes | Because TNF and IL-1β are known to mediate synovitis, pannus formation, and erosion of cartilage and bone in RA, the decreased serum levels of TNF and IL-1β in A20-transduced mice might explain the beneficial effects in the clinical, pathological, and radiological findings. |
T115 | 21128-21256 | Sentence | denotes | This study also demonstrated that A20 overexpression leads to a decrease in the number of activated osteoclasts in joint tissue. |
T116 | 21257-21358 | Sentence | denotes | A20 might therefore minimise joint destruction through decreasing the osteoclast number and activity. |
T117 | 21359-21567 | Sentence | denotes | It will be interesting to analyse in future the susceptibility of conditional knockout mice that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells. |
T118 | 21568-21728 | Sentence | denotes | Importantly, several SNPs in the human A20 locus have been associated with increased susceptibility to development of autoimmune pathologies (reviewed in [52]). |
T119 | 21729-21891 | Sentence | denotes | Several genome-wide association studies also revealed a clear association between mutations in the A20 locus in the 6q23 chromosome and susceptibility to RA [52]. |
T120 | 21892-22112 | Sentence | denotes | Although the identified variants are not located in a gene, they are thought to influence A20 as its nearest gene (~150 kb downstream of A20), probably by the presence of potential regulatory DNA elements in this region. |
T121 | 22113-22293 | Sentence | denotes | As A20 is required for termination of TNF-induced signals, and TNF is the primary inflammatory cytokine in RA, these findings reveal A20 as a candidate susceptibility locus for RA. |
T122 | 22294-22387 | Sentence | denotes | How these variants affect normal A20 activity and how they cause RA, however, remain unclear. |
T123 | 22388-22612 | Sentence | denotes | Recently, Elsby and colleagues functionally evaluated in vitro the regulatory ability of RA-associated SNP variants on A20 promoter activity, and could show repressed A20 transcription for some of the SNPs investigated [53]. |
T124 | 22613-22738 | Sentence | denotes | It will be of interest to identify the actual causal variants and to elucidate the functional consequences of these variants. |
T125 | 22739-22864 | Sentence | denotes | In this context, knockin mice for the corresponding A20 SNPs, combined with mouse models for RA, will be very valuable tools. |
T126 | 22866-22897 | Sentence | denotes | A20-binding inhibitors of NF-κB |
T127 | 22898-23143 | Sentence | denotes | ABIN-1, ABIN-2 and ABIN-3 (also known as TNIP-1, TNIP-2, and TNIP-3) were identified as ubiquitously expressed A20 interacting proteins and were shown to inhibit NF-κB activation by TNF and several other inflammatory stimuli upon overexpression. |
T128 | 23144-23280 | Sentence | denotes | Because ABINs contain a specific ubiquitin-binding motif, they have been proposed to target A20 to polyubiquitinated substrates [43,44]. |
T129 | 23281-23475 | Sentence | denotes | Similar to A20, ABIN-1 and ABIN-3 expression is NF-κB dependent, implicating a potential role for the A20/ABIN complex in the negative feedback regulation of NF-κB activation (reviewed in [54]). |
T130 | 23476-23695 | Sentence | denotes | Unexpectedly, both ABIN-1-deficient and ABIN-2-deficient mice exhibit only slightly increased or normal NF-κB responses, respectively, possibly reflecting redundant NF-κB inhibitory activities of multiple ABINs [55,56]. |
T131 | 23696-23840 | Sentence | denotes | Functional ABIN-3 is expressed in humans, but mice only express a truncated and inactive form lacking the crucial ubiquitin-binding domain [57]. |
T132 | 23841-24004 | Sentence | denotes | As for A20, ABIN-1 also strongly inhibits TNF-induced apoptosis [58], and ABIN-1 deficient mice die embryonically due to TNF-dependent foetal liver apoptosis [56]. |
T133 | 24005-24332 | Sentence | denotes | Using oligonucleotide microarray analysis, ABIN-1 was identified among TNF-induced genes in human synoviocytes, and high levels of ABIN-1 mRNA were detected in RA tissue biopsies, indicating a potential role for ABIN-1, together with A20, in the negative feedback regulation of NF-κB signalling and the pathogenesis of RA [59]. |
T134 | 24333-24541 | Sentence | denotes | In a recent study, inhibition of TLR responses by immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptors was shown to depend on the expression of the NF-κB inhibitory proteins ABIN-3 and A20. |
T135 | 24542-24663 | Sentence | denotes | Moreover, this protective effect of the ITAM was strongly suppressed in inflammatory arthritis synovial macrophages [60]. |
T136 | 24664-24787 | Sentence | denotes | Interestingly, ABIN-1 polymorphisms have been associated with psoriasis and systemic lupus erythematosus in humans [61,62]. |
T137 | 24788-25071 | Sentence | denotes | A high degree of overlap between systemic lupus erythematosus and RA susceptibility loci might be expected as the two diseases show some clinical overlap in joint involvement, autoantibody production, systemic features and response to treatments such as B-cell depletion (rituximab). |
T138 | 25072-25236 | Sentence | denotes | It will therefore be interesting to investigate whether SNPs that have been reported to be associated with systemic lupus erythematosus are also associated with RA. |
T139 | 25238-25261 | Sentence | denotes | Cylindromatosis protein |
T140 | 25262-25384 | Sentence | denotes | Cylindromatosis (CYLD) protein was originally identified as a tumour suppressor involved in familial cylindromatosis [63]. |
T141 | 25385-25577 | Sentence | denotes | CYLD is also involved, however, in diverse physiological processes ranging from immunity and inflammation to cell cycle progression, spermatogenesis, and osteoclastogenesis (reviewed in [64]). |
T142 | 25578-25848 | Sentence | denotes | CYLD is a deubiquitinating enzyme that negatively regulates NF-κB signalling initiated by TNFR, RANK and T-cell receptor stimulation (reviewed in [64]) (Figure 1), by deubiquitina-ting several NF-κB signalling proteins including NEMO, TRAF2, TRAF6, TRAF7, RIP1 and TAK1. |
T143 | 25849-25981 | Sentence | denotes | Many of these are also targeted by A20 and it is still not clear why the cell needs A20 as well as CYLD to control NF-κB activation. |
T144 | 25982-26197 | Sentence | denotes | As A20 is only expressed in many cell types upon stimulation, it has been suggested that this protein mainly regulates later phases of NF-κB signalling, whereas CYLD would regulate constitutive and early signalling. |
T145 | 26198-26274 | Sentence | denotes | In addition, their relative activity might also be cell-type dependent [64]. |
T146 | 26275-26385 | Sentence | denotes | Interestingly, CYLD has been shown to negatively regulate RANK signalling and osteoclastogenesis in mice [65]. |
T147 | 26386-26498 | Sentence | denotes | Mice with a genetic deficiency of CYLD have aberrant osteoclast differentiation and develop severe osteoporosis. |
T148 | 26499-26629 | Sentence | denotes | Osteoclast precursors of these mice are hyper-responsive to RANKL-induced differentiation and produce more and larger osteoclasts. |
T149 | 26630-26902 | Sentence | denotes | CYLD expression is markedly upregulated under conditions of RANKL-induced osteoclastogenesis and is recruited to ubiquitinated TRAF6 via the ubiquitin-binding adaptor protein p62 (also known as sequestosome 1) [65], followed by the CYLD-mediated deubiquitination of TRAF6. |
T150 | 26903-27077 | Sentence | denotes | In this context, it is worth mentioning that transgenic mice expressing a mutated form of p62 also display abnormal osteoclastogenesis and develop progressive bone loss [66]. |
T151 | 27078-27334 | Sentence | denotes | These findings suggest that CYLD-mediated inhibi-tion of RANK-induced NF-κB signalling plays a key role in the negative regulation of osteoclastogenesis and indicate CYLD as a potential genetic factor involved in the pathology of bone disorders such as RA. |
T152 | 27336-27387 | Sentence | denotes | Single-immunoglobulin IL-1 receptor-related protein |
T153 | 27388-27688 | Sentence | denotes | Single-immunoglobulin IL-1 receptor-related (SIGIRR) protein, also known as TIR-8, is a member of the TLR/IL-1R family that has been extensively characterised as an inhibitor of IL-1R and TLR signalling, probably through direct interaction with these receptors, MyD88, IRAK1 or TRAF6 [67] (Figure 1). |
T154 | 27689-27842 | Sentence | denotes | Given the important role of IL-1R and TLR signalling in the chronic inflammation observed in RA [68], a regulatory role for SIGIRR in RA is not unlikely. |
T155 | 27843-28008 | Sentence | denotes | SIGIRR has a very restricted expression pattern, being expressed in epithelial cells, monocytes and immature dendritic cells, but not in mature macro-phages [69,70]. |
T156 | 28009-28139 | Sentence | denotes | Recently, SIGIRR overexpression was shown to inhibit the spontaneous release of inflammatory cytokines by human RA synovial cells. |
T157 | 28140-28352 | Sentence | denotes | This inhibitory function of SIGIRR was further confirmed in vivo, since SIGIRR-deficient mice developed a more severe disease in zymosan-induced arthritis, as well as collagen-induced arthritis mouse models [70]. |
T158 | 28353-28547 | Sentence | denotes | It will be interesting to compare the expression of SIGIRR in RA patients with its expression in control patients, or to investigate whether the function of SIGIRR is compromised in RA patients. |
T159 | 28548-28653 | Sentence | denotes | Because of its restricted expression pattern, SIGIRR may also be an interesting therapeutic target in RA. |
T160 | 28655-28687 | Sentence | denotes | TNF receptor-associated factor 1 |
T161 | 28688-28824 | Sentence | denotes | TRAF1 is a unique member of the TRAF protein family because it lacks a RING finger domain and therefore lacks ubiquitin ligase activity. |
T162 | 28825-29014 | Sentence | denotes | Accumulating data support a role for TRAF1 as both a negative and a positive modulator of NF-κB signalling by certain TNF family receptors, possibly in a cell-type-dependent manner [71,72]. |
T163 | 29015-29121 | Sentence | denotes | Expression of TRAF1 is inducible by TNF and overexpression of TRAF1 inhibits TNF-induced NF-κB activation. |
T164 | 29122-29250 | Sentence | denotes | TRAF1-deficient T cells are hyper-responsive to TNF, with enhanced proliferation and activation of the NF-κB signalling pathway. |
T165 | 29251-29329 | Sentence | denotes | TRAF1 also functions as a negative regulator of CD40-induced NF-κB activation. |
T166 | 29330-29504 | Sentence | denotes | TRAF1-deficient dendritic cells, however, show attenuated responses to secondary stimulation by TRAF2-dependent factors, suggesting a positive regulatory role in these cells. |
T167 | 29505-29579 | Sentence | denotes | The mechanism by which TRAF1 modulates NF- κB activation is still unclear. |
T168 | 29580-29692 | Sentence | denotes | Most probably, TRAF1 competes with TRAF family members for binding to the receptor or other signalling proteins. |
T169 | 29693-29775 | Sentence | denotes | Alternatively, TRAF1 might recruit A20 with which it can physically interact [73]. |
T170 | 29776-30025 | Sentence | denotes | A genome-wide association study examining more than 300,000 SNPs among approximately 1,500 autoantibody-positive RA cases and 1,800 controls identified a genetic variation at the TRAF1-complement component 5 locus as an important RA risk locus [74]. |
T171 | 30026-30109 | Sentence | denotes | Subsequent work indicates that TRAF1 is more likely to be the causative locus [75]. |
T172 | 30110-30216 | Sentence | denotes | Recent work in a Korean population also demonstrates genetic association of the TRAF1 region with RA [76]. |
T173 | 30218-30227 | Sentence | denotes | microRNAs |
T174 | 30228-30438 | Sentence | denotes | miRNAs are recently discovered regulators of gene expression and represent a class of noncoding RNA molecules essential in many cellular and developmental processes, including immune responses and inflammation. |
T175 | 30439-30574 | Sentence | denotes | They bind the 3'-UTR of target mRNAs leading to the repression of protein expression and the promotion of target mRNA degradation [77]. |
T176 | 30575-30757 | Sentence | denotes | miR-146a/b and miR-155 are of particular interest for inflammatory signalling to NF-κB, since these miRNAs can be induced by inflammatory stimuli such as IL-1β, TNF and TLRs [78,79]. |
T177 | 30758-30919 | Sentence | denotes | In addition, miR-146a is an NF-κB-dependent gene, and the NF-κB signalling molecules IRAK1 and TRAF6 were identified as target genes of miR-146a [78] (Figure 1). |
T178 | 30920-31028 | Sentence | denotes | Similarly, miR-155 was shown to target transcripts for the NF-κB signalling molecules IKKε and RIP1 [79,80]. |
T179 | 31029-31312 | Sentence | denotes | Notably, both miR-146 and miR-155 are expressed at higher levels in RA synovial fibroblasts and synovial tissue [81,82], as well as in peripheral blood mononuclear cells of RA patients [83]. miR-146a is also overexpressed in CD4+ and IL-17-producing T cells from RA patients [84,85]. |
T180 | 31313-31640 | Sentence | denotes | Interestingly, a polymorphism in the 3'-UTR of the miR-146a target gene was recently shown to be associated with RA susceptibility [86]. miR-155 overexpression in synovial fibroblasts was able to prevent the TLR and cytokine-inducible expression of specific matrix metalloproteinases that mediate tissue destruction in RA [81]. |
T181 | 31641-31904 | Sentence | denotes | Moreover, miR-155 was shown to promote TNF production, a key process in the pathogenesis of RA [87]. miR-146 and miR-155 may therefore be important negative regulators of inflammation in RA and their potential for the development of new treatments is substantial. |
T182 | 31905-32131 | Sentence | denotes | In addition, their increased expression in RA patients is potentially useful as a marker for disease diagnosis, progression, or treatment efficacy [88], but this will require confirmation using a large and well-defined cohort. |
T183 | 32132-32306 | Sentence | denotes | Besides miR-146 and miR-155, a number of other miRNAs with a potential role in the control of NF-κB-dependent inflammatory responses in RA pathology were recently identified. |
T184 | 32307-32469 | Sentence | denotes | In this context, miR-124a - a key regulator of the chemokine monocyte chemoattractant protein 1 - was shown to be decreased in synoviocytes from RA patients [89]. |
T185 | 32470-32628 | Sentence | denotes | Similarly, elevated levels of miR-203 - leading to increased secretion of matrix metalloproteinase-1 and IL-6 - were detected in RA synovial fibroblasts [90]. |
T186 | 32629-32809 | Sentence | denotes | Finally, miR-16, miR-132, and miR-223 were also shown to have an altered expression in RA patients, indicating their potential as diagnostic biomarkers for pathogenesis [83,88,91]. |
T187 | 32811-32822 | Sentence | denotes | Conclusions |
T188 | 32823-32963 | Sentence | denotes | The NF-κB family of transcription factors plays crucial roles in the inflammatory processes in RA leading to cartilage and bone destruction. |
T189 | 32964-33070 | Sentence | denotes | Keeping NF-κB activation under control can thus be very important for the design of specific therapeutics. |
T190 | 33071-33279 | Sentence | denotes | The existence of multiple negative regulators ensuring a tight regulation of the NF-κB pathway, however, raises the question of the specific role of each of these regulators and the relationship between them. |
T191 | 33280-33401 | Sentence | denotes | In addition, given the number of miRNAs in humans and the multiple mRNAs they target, intense complexity can be expected. |
T192 | 33402-33651 | Sentence | denotes | How all these regulatory signals are themselves regulated will be an important question in order to clarify how NF-κB signalling is organised, and, more importantly, how this knowledge may lead to new treatments for inflammatory diseases such as RA. |
T193 | 33653-33666 | Sentence | denotes | Abbreviations |
T194 | 33667-34405 | Sentence | denotes | ABIN: A20-binding inhibitor of NF-κB; BAFF: B-cell activating factor; cIAP: cellular inhibitor of apoptosis; CYLD: cylindromatosis; HMGB1: high mobility group box chromosomal protein 1; IFN: interferon; IKK: IκB kinase; IκB: inhibitor of NF-κB; IL: interleukin; IRAK: IL-1R-associated kinase; ITAM: immunoreceptor tyrosine-based activation motif; miRNA: microRNA; MyD88: myeloid differentiation primary response gene 88; NEMO: NF-κB essential modulator; NF: nuclear factor; NIK: NF-κB inducing kinase; RA: rheumatoid arthritis; RANK: receptor activator of NF-κB; RANKL: receptor activator of NF-κB ligand; RIP1: receptor interacting protein 1; SIGIRR: single-immunoglobulin IL-1 receptor-related; SNP: single nucleotide polymorphism; TIR: |
T195 | 34406-34474 | Sentence | denotes | Toll-like receptor/IL-1R; TRAF: TNF receptor-associated factor; TLR: |
T196 | 34475-34600 | Sentence | denotes | Toll-like receptor; TNF: tumour necrosis factor; TRIF: TIR domain-containing adaptor-inducing IFNβ; UTR: untranslated region. |
T197 | 34602-34621 | Sentence | denotes | Competing interests |
T198 | 34622-34680 | Sentence | denotes | The authors declare that they have no competing interests. |
ICD10
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T15774 | 28324-28333 | http://purl.bioontology.org/ontology/ICD10/M13.9 | denotes | arthritis |
T15773 | 28285-28294 | http://purl.bioontology.org/ontology/ICD10/M13.9 | denotes | arthritis |
T14595 | 27308-27322 | http://purl.bioontology.org/ontology/ICD10/M89.9 | denotes | bone disorders |
T14594 | 26485-26497 | http://purl.bioontology.org/ontology/ICD10/M81.9 | denotes | osteoporosis |
T13143 | 25188-25207 | http://purl.bioontology.org/ontology/ICD10/L93 | denotes | lupus erythematosus |
T13142 | 24830-24849 | http://purl.bioontology.org/ontology/ICD10/L93 | denotes | lupus erythematosus |
T13141 | 24749-24768 | http://purl.bioontology.org/ontology/ICD10/L93 | denotes | lupus erythematosus |
T10726 | 20755-20764 | http://purl.bioontology.org/ontology/ICD10/M13.9 | denotes | arthritis |
T10725 | 20414-20423 | http://purl.bioontology.org/ontology/ICD10/M13.9 | denotes | arthritis |
T10724 | 19195-19203 | http://purl.bioontology.org/ontology/ICD10/R64 | denotes | cachexia |
T2515 | 6287-6296 | http://purl.bioontology.org/ontology/ICD10/M13.9 | denotes | arthritis |
T2514 | 4631-4640 | http://purl.bioontology.org/ontology/ICD10/M13.9 | denotes | arthritis |
T803 | 837-850 | http://purl.bioontology.org/ontology/ICD10/M13.0 | denotes | polyarthritis |
T13140 | 25179-25207 | http://purl.bioontology.org/ontology/ICD10/M32 | denotes | systemic lupus erythematosus |
T13139 | 24821-24849 | http://purl.bioontology.org/ontology/ICD10/M32 | denotes | systemic lupus erythematosus |
T13138 | 24740-24768 | http://purl.bioontology.org/ontology/ICD10/M32 | denotes | systemic lupus erythematosus |
T13137 | 25179-25207 | http://purl.bioontology.org/ontology/ICD10/M32.9 | denotes | systemic lupus erythematosus |
T13136 | 24821-24849 | http://purl.bioontology.org/ontology/ICD10/M32.9 | denotes | systemic lupus erythematosus |
T13135 | 24740-24768 | http://purl.bioontology.org/ontology/ICD10/M32.9 | denotes | systemic lupus erythematosus |
T13134 | 24726-24735 | http://purl.bioontology.org/ontology/ICD10/L40.9 | denotes | psoriasis |
T13133 | 24726-24735 | http://purl.bioontology.org/ontology/ICD10/L40 | denotes | psoriasis |
T13132 | 24627-24636 | http://purl.bioontology.org/ontology/ICD10/M13.9 | denotes | arthritis |
T802 | 2254-2263 | http://purl.bioontology.org/ontology/ICD10/M13.9 | denotes | arthritis |
T801 | 745-754 | http://purl.bioontology.org/ontology/ICD10/M13.9 | denotes | arthritis |
T800 | 698-707 | http://purl.bioontology.org/ontology/ICD10/M13.9 | denotes | arthritis |
T799 | 687-707 | http://purl.bioontology.org/ontology/ICD10/M06.9 | denotes | Rheumatoid arthritis |
T109 | 296-316 | http://purl.bioontology.org/ontology/ICD10/M06.9 | denotes | rheumatoid arthritis |
T110 | 651-671 | http://purl.bioontology.org/ontology/ICD10/M06.9 | denotes | rheumatoid arthritis |
T112 | 307-316 | http://purl.bioontology.org/ontology/ICD10/M13.9 | denotes | arthritis |
T113 | 662-671 | http://purl.bioontology.org/ontology/ICD10/M13.9 | denotes | arthritis |
T108 | 52-72 | http://purl.bioontology.org/ontology/ICD10/M06.9 | denotes | rheumatoid arthritis |
T111 | 63-72 | http://purl.bioontology.org/ontology/ICD10/M13.9 | denotes | arthritis |
simple1
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T21825 | 14085-14090 | Protein | denotes | TRAF2 |
T21824 | 14028-14031 | Protein | denotes | NIK |
T21823 | 13982-13985 | Protein | denotes | NIK |
T21822 | 13959-13980 | Protein | denotes | NF-κB inducing kinase |
T21821 | 13889-13893 | Protein | denotes | RANK |
T21820 | 13880-13884 | Protein | denotes | CD40 |
T21853 | 15143-15165 | Protein | denotes | tumour necrosis factor |
T21852 | 15138-15141 | Protein | denotes | TNF |
T21851 | 15071-15098 | Protein | denotes | receptor activator of NF-κB |
T21850 | 15065-15069 | Protein | denotes | RANK |
T21849 | 14846-14851 | Protein | denotes | TRAF1 |
T21848 | 14839-14844 | Protein | denotes | TRAF3 |
T21847 | 14799-14803 | Protein | denotes | RelB |
T21846 | 14763-14766 | Protein | denotes | p52 |
T21845 | 14755-14759 | Protein | denotes | p100 |
T21844 | 14644-14648 | Protein | denotes | p100 |
T21843 | 14617-14621 | Protein | denotes | IKK1 |
T21842 | 14579-14582 | Protein | denotes | NIK |
T21841 | 14555-14558 | Protein | denotes | NIK |
T21840 | 14513-14516 | Protein | denotes | NIK |
T21839 | 14491-14496 | Protein | denotes | TRAF3 |
T21838 | 14473-14476 | Protein | denotes | NIK |
T21837 | 14454-14459 | Protein | denotes | TRAF3 |
T21836 | 14407-14408 | Protein | denotes | 2 |
T21835 | 14401-14406 | Protein | denotes | cIAP1 |
T21834 | 14354-14355 | Protein | denotes | 2 |
T21833 | 14348-14353 | Protein | denotes | cIAP1 |
T21832 | 14286-14291 | Protein | denotes | TRAF2 |
T21831 | 14244-14249 | Protein | denotes | TRAF3 |
T21830 | 14207-14210 | Protein | denotes | NIK |
T21829 | 14194-14197 | Protein | denotes | NIK |
T21828 | 14108-14109 | Protein | denotes | 2 |
T21827 | 14102-14107 | Protein | denotes | cIAP1 |
T21826 | 14092-14097 | Protein | denotes | TRAF3 |
T20178 | 10701-10723 | Protein | denotes | tumour necrosis factor |
T20177 | 10696-10699 | Protein | denotes | TNF |
T20176 | 10558-10600 | Protein | denotes | single-immunoglobulinIL-1 receptor-related |
T20175 | 10550-10556 | Protein | denotes | SIGIRR |
T20174 | 10518-10548 | Protein | denotes | receptor interacting protein 1 |
T20173 | 10512-10516 | Protein | denotes | RIP1 |
T20172 | 10483-10510 | Protein | denotes | receptor activator of NF-κB |
T20171 | 10477-10481 | Protein | denotes | RANK |
T20170 | 10430-10455 | Protein | denotes | NF-κB essential modulator |
T20169 | 10424-10428 | Protein | denotes | NEMO |
T20168 | 10374-10422 | Protein | denotes | myeloid differentiation primary response gene 88 |
T20167 | 10367-10372 | Protein | denotes | MyD88 |
T20166 | 10277-10292 | Protein | denotes | cylindromatosis |
T20165 | 10271-10275 | Protein | denotes | CYLD |
T20164 | 10200-10230 | Protein | denotes | A20-binding inhibitor of NF-κB |
T20163 | 10194-10198 | Protein | denotes | ABIN |
T20162 | 10031-10036 | Protein | denotes | TRAF6 |
T20161 | 10021-10026 | Protein | denotes | IRAK1 |
T20160 | 10001-10005 | Protein | denotes | TLR4 |
T20159 | 9953-9959 | Protein | denotes | SIGIRR |
T20158 | 9871-9876 | Protein | denotes | TRAF6 |
T20157 | 9861-9866 | Protein | denotes | IRAK1 |
T20156 | 9771-9774 | Protein | denotes | p62 |
T20155 | 9760-9766 | Protein | denotes | ABIN-1 |
T20154 | 9667-9672 | Protein | denotes | TRAF6 |
T20153 | 9658-9662 | Protein | denotes | RIP1 |
T20152 | 9542-9546 | Protein | denotes | CYLD |
T20151 | 9534-9537 | Protein | denotes | A20 |
T20150 | 9400-9405 | Protein | denotes | TRAF1 |
T20149 | 9329-9332 | Protein | denotes | p50 |
T20148 | 9321-9324 | Protein | denotes | p65 |
T20147 | 9195-9199 | Protein | denotes | IκBα |
T20146 | 9160-9164 | Protein | denotes | IKK2 |
T20145 | 9121-9125 | Protein | denotes | TAK1 |
T20144 | 9115-9119 | Protein | denotes | TAK1 |
T20143 | 9106-9110 | Protein | denotes | IKK2 |
T20142 | 9023-9027 | Protein | denotes | NEMO |
T20141 | 8999-9004 | Protein | denotes | IRAK1 |
T20140 | 8990-8994 | Protein | denotes | RIP1 |
T20139 | 8926-8931 | Protein | denotes | cIAP2 |
T20138 | 8919-8924 | Protein | denotes | cIAP1 |
T20137 | 8912-8917 | Protein | denotes | TRAF6 |
T20136 | 8905-8910 | Protein | denotes | TRAF2 |
T20135 | 8874-8879 | Protein | denotes | IRAK4 |
T20134 | 8867-8872 | Protein | denotes | IRAK1 |
T20133 | 8861-8865 | Protein | denotes | RIP1 |
T20132 | 8844-8848 | Protein | denotes | TRIF |
T20131 | 8799-8842 | Protein | denotes | TIR domain-containing adaptor-inducing IFNβ |
T20130 | 8794-8797 | Protein | denotes | MAL |
T20129 | 8787-8792 | Protein | denotes | MyD88 |
T20128 | 8779-8784 | Protein | denotes | TRADD |
T20127 | 8731-8777 | Protein | denotes | TNF receptor 1-associated death domain protein |
T20126 | 8672-8676 | Protein | denotes | TLR4 |
T20125 | 8662-8666 | Protein | denotes | RANK |
T20124 | 8656-8660 | Protein | denotes | CD40 |
T20123 | 8649-8654 | Protein | denotes | TNFR1 |
T18038 | 32659-32666 | Protein | denotes | miR-223 |
T18037 | 32646-32653 | Protein | denotes | miR-132 |
T18036 | 32638-32644 | Protein | denotes | miR-16 |
T18035 | 32575-32579 | Protein | denotes | IL-6 |
T18034 | 32544-32570 | Protein | denotes | matrix metalloproteinase-1 |
T18033 | 32500-32507 | Protein | denotes | miR-203 |
T18032 | 32368-32402 | Protein | denotes | monocyte chemoattractant protein 1 |
T18031 | 32324-32332 | Protein | denotes | miR-124a |
T18030 | 32152-32159 | Protein | denotes | miR-155 |
T18029 | 31754-31761 | Protein | denotes | miR-155 |
T18028 | 31680-31683 | Protein | denotes | TNF |
T18027 | 31651-31658 | Protein | denotes | miR-155 |
T18026 | 31450-31457 | Protein | denotes | miR-155 |
T18025 | 31364-31372 | Protein | denotes | miR-146a |
T18024 | 31263-31268 | Protein | denotes | IL-17 |
T18023 | 31254-31257 | Protein | denotes | CD4 |
T18022 | 31220-31228 | Protein | denotes | miR-146a |
T18021 | 31055-31062 | Protein | denotes | miR-155 |
T18020 | 31015-31019 | Protein | denotes | RIP1 |
T18019 | 31006-31010 | Protein | denotes | IKKε |
T18018 | 30931-30938 | Protein | denotes | miR-155 |
T18017 | 30894-30902 | Protein | denotes | miR-146a |
T18016 | 30853-30858 | Protein | denotes | TRAF6 |
T18015 | 30843-30848 | Protein | denotes | IRAK1 |
T18014 | 30771-30779 | Protein | denotes | miR-146a |
T18013 | 30736-30739 | Protein | denotes | TNF |
T18012 | 30729-30734 | Protein | denotes | IL-1β |
T18011 | 30590-30597 | Protein | denotes | miR-155 |
T18010 | 30584-30585 | Protein | denotes | b |
T18009 | 30575-30583 | Protein | denotes | miR-146a |
T16745 | 30190-30195 | Protein | denotes | TRAF1 |
T16744 | 30057-30062 | Protein | denotes | TRAF1 |
T16743 | 29955-29960 | Protein | denotes | TRAF1 |
T16742 | 29728-29731 | Protein | denotes | A20 |
T16741 | 29708-29713 | Protein | denotes | TRAF1 |
T16740 | 29595-29600 | Protein | denotes | TRAF1 |
T16739 | 29528-29533 | Protein | denotes | TRAF1 |
T16738 | 29426-29431 | Protein | denotes | TRAF2 |
T16737 | 29330-29335 | Protein | denotes | TRAF1 |
T16736 | 29299-29303 | Protein | denotes | CD40 |
T16735 | 29251-29256 | Protein | denotes | TRAF1 |
T16734 | 29170-29173 | Protein | denotes | TNF |
T16733 | 29122-29127 | Protein | denotes | TRAF1 |
T16732 | 29092-29095 | Protein | denotes | TNF |
T16731 | 29077-29082 | Protein | denotes | TRAF1 |
T16730 | 29051-29054 | Protein | denotes | TNF |
T16729 | 29029-29034 | Protein | denotes | TRAF1 |
T16728 | 28862-28867 | Protein | denotes | TRAF1 |
T16727 | 28798-28807 | Protein | denotes | ubiquitin |
T16726 | 28688-28693 | Protein | denotes | TRAF1 |
T16725 | 28655-28687 | Protein | denotes | TNF receptor-associated factor 1 |
T15829 | 28594-28600 | Protein | denotes | SIGIRR |
T15828 | 28510-28516 | Protein | denotes | SIGIRR |
T15827 | 28405-28411 | Protein | denotes | SIGIRR |
T15826 | 28212-28218 | Protein | denotes | SIGIRR |
T15825 | 28168-28174 | Protein | denotes | SIGIRR |
T15824 | 28019-28025 | Protein | denotes | SIGIRR |
T15823 | 27843-27849 | Protein | denotes | SIGIRR |
T15822 | 27813-27819 | Protein | denotes | SIGIRR |
T15821 | 27717-27722 | Protein | denotes | IL-1R |
T15820 | 27666-27671 | Protein | denotes | TRAF6 |
T15819 | 27657-27662 | Protein | denotes | IRAK1 |
T15818 | 27650-27655 | Protein | denotes | MyD88 |
T15817 | 27566-27571 | Protein | denotes | IL-1R |
T15816 | 27464-27469 | Protein | denotes | TIR-8 |
T15815 | 27433-27439 | Protein | denotes | SIGIRR |
T15814 | 27388-27431 | Protein | denotes | Single-immunoglobulin IL-1 receptor-related |
T15813 | 27336-27379 | Protein | denotes | Single-immunoglobulin IL-1 receptor-related |
T14638 | 27244-27248 | Protein | denotes | CYLD |
T14637 | 27135-27139 | Protein | denotes | RANK |
T14636 | 27106-27110 | Protein | denotes | CYLD |
T14635 | 26993-26996 | Protein | denotes | p62 |
T14634 | 26896-26901 | Protein | denotes | TRAF6 |
T14633 | 26862-26866 | Protein | denotes | CYLD |
T14632 | 26824-26838 | Protein | denotes | sequestosome 1 |
T14631 | 26805-26808 | Protein | denotes | p62 |
T14630 | 26771-26780 | Protein | denotes | ubiquitin |
T14629 | 26757-26762 | Protein | denotes | TRAF6 |
T14628 | 26690-26695 | Protein | denotes | RANKL |
T14627 | 26630-26634 | Protein | denotes | CYLD |
T14626 | 26559-26564 | Protein | denotes | RANKL |
T14625 | 26420-26424 | Protein | denotes | CYLD |
T14624 | 26333-26337 | Protein | denotes | RANK |
T14623 | 26290-26294 | Protein | denotes | CYLD |
T14622 | 26143-26147 | Protein | denotes | CYLD |
T14621 | 25985-25988 | Protein | denotes | A20 |
T14620 | 25948-25952 | Protein | denotes | CYLD |
T14619 | 25933-25936 | Protein | denotes | A20 |
T14618 | 25884-25887 | Protein | denotes | A20 |
T14617 | 25843-25847 | Protein | denotes | TAK1 |
T14616 | 25834-25838 | Protein | denotes | RIP1 |
T14615 | 25827-25832 | Protein | denotes | TRAF7 |
T14614 | 25820-25825 | Protein | denotes | TRAF6 |
T14613 | 25813-25818 | Protein | denotes | TRAF2 |
T14612 | 25807-25811 | Protein | denotes | NEMO |
T14611 | 25674-25678 | Protein | denotes | RANK |
T14610 | 25588-25611 | Protein | denotes | deubiquitinating enzyme |
T14609 | 25578-25582 | Protein | denotes | CYLD |
T14608 | 25385-25389 | Protein | denotes | CYLD |
T14607 | 25279-25283 | Protein | denotes | CYLD |
T14606 | 25262-25277 | Protein | denotes | Cylindromatosis |
T14605 | 25238-25253 | Protein | denotes | Cylindromatosis |
T13200 | 24679-24685 | Protein | denotes | ABIN-1 |
T13199 | 24537-24540 | Protein | denotes | A20 |
T13198 | 24526-24532 | Protein | denotes | ABIN-3 |
T13197 | 24239-24242 | Protein | denotes | A20 |
T13196 | 24217-24223 | Protein | denotes | ABIN-1 |
T13195 | 24136-24142 | Protein | denotes | ABIN-1 |
T13194 | 24076-24079 | Protein | denotes | TNF |
T13193 | 24048-24054 | Protein | denotes | ABIN-1 |
T13192 | 23962-23965 | Protein | denotes | TNF |
T13191 | 23915-23921 | Protein | denotes | ABIN-1 |
T13190 | 23883-23886 | Protein | denotes | TNF |
T13189 | 23853-23859 | Protein | denotes | ABIN-1 |
T13188 | 23848-23851 | Protein | denotes | A20 |
T13187 | 23762-23789 | Protein | denotes | truncated and inactive form |
T13186 | 23707-23713 | Protein | denotes | ABIN-3 |
T13185 | 23516-23522 | Protein | denotes | ABIN-2 |
T13184 | 23495-23501 | Protein | denotes | ABIN-1 |
T13183 | 23383-23386 | Protein | denotes | A20 |
T13182 | 23308-23314 | Protein | denotes | ABIN-3 |
T13181 | 23297-23303 | Protein | denotes | ABIN-1 |
T13180 | 23292-23295 | Protein | denotes | A20 |
T13179 | 23236-23239 | Protein | denotes | A20 |
T13178 | 23080-23083 | Protein | denotes | TNF |
T13177 | 23009-23012 | Protein | denotes | A20 |
T13176 | 22959-22965 | Protein | denotes | TNIP-3 |
T13175 | 22947-22953 | Protein | denotes | TNIP-2 |
T13174 | 22939-22945 | Protein | denotes | TNIP-1 |
T13173 | 22917-22923 | Protein | denotes | ABIN-3 |
T13172 | 22906-22912 | Protein | denotes | ABIN-2 |
T13171 | 22898-22904 | Protein | denotes | ABIN-1 |
T13170 | 22866-22869 | Protein | denotes | A20 |
T10796 | 22791-22794 | Protein | denotes | A20 |
T10795 | 22555-22558 | Protein | denotes | A20 |
T10794 | 22507-22510 | Protein | denotes | A20 |
T10793 | 22327-22330 | Protein | denotes | A20 |
T10792 | 22246-22249 | Protein | denotes | A20 |
T10791 | 22208-22216 | Protein | denotes | cytokine |
T10790 | 22176-22179 | Protein | denotes | TNF |
T10789 | 22151-22154 | Protein | denotes | TNF |
T10788 | 22116-22119 | Protein | denotes | A20 |
T10787 | 22029-22032 | Protein | denotes | A20 |
T10786 | 21982-21985 | Protein | denotes | A20 |
T10785 | 21828-21831 | Protein | denotes | A20 |
T10784 | 21607-21610 | Protein | denotes | A20 |
T10783 | 21461-21464 | Protein | denotes | A20 |
T10782 | 21257-21260 | Protein | denotes | A20 |
T10781 | 21162-21165 | Protein | denotes | A20 |
T10780 | 21013-21016 | Protein | denotes | A20 |
T10779 | 21004-21009 | Protein | denotes | IL-1β |
T10778 | 20996-20999 | Protein | denotes | TNF |
T10777 | 20869-20874 | Protein | denotes | IL-1β |
T10776 | 20861-20864 | Protein | denotes | TNF |
T10775 | 20703-20706 | Protein | denotes | A20 |
T10774 | 20639-20674 | Protein | denotes | monocyte chemo-attractant protein 1 |
T10773 | 20632-20637 | Protein | denotes | RANKL |
T10772 | 20618-20622 | Protein | denotes | IL-6 |
T10771 | 20611-20616 | Protein | denotes | IL-1β |
T10770 | 20606-20609 | Protein | denotes | TNF |
T10769 | 20499-20502 | Protein | denotes | A20 |
T10768 | 20271-20274 | Protein | denotes | A20 |
T10767 | 20168-20171 | Protein | denotes | A20 |
T10766 | 20106-20109 | Protein | denotes | A20 |
T10765 | 19929-19932 | Protein | denotes | A20 |
T10764 | 19798-19801 | Protein | denotes | A20 |
T10763 | 19677-19680 | Protein | denotes | A20 |
T10762 | 19643-19646 | Protein | denotes | TNF |
T10761 | 19483-19486 | Protein | denotes | A20 |
T10760 | 19360-19363 | Protein | denotes | TNF |
T10759 | 19311-19314 | Protein | denotes | A20 |
T10758 | 19126-19129 | Protein | denotes | A20 |
T10757 | 19062-19065 | Protein | denotes | A20 |
T10756 | 18964-18967 | Protein | denotes | A20 |
T10755 | 18882-18904 | Protein | denotes | Tax1-binding protein 1 |
T10754 | 18838-18877 | Protein | denotes | A20-binding inhibitor of NF-κB (ABIN) 1 |
T10753 | 18753-18756 | Protein | denotes | A20 |
T10752 | 18691-18694 | Protein | denotes | A20 |
T10751 | 18634-18635 | Protein | denotes | 2 |
T10750 | 18628-18633 | Protein | denotes | cIAP1 |
T10749 | 18618-18623 | Protein | denotes | TRAF2 |
T10748 | 18611-18616 | Protein | denotes | TRAF6 |
T10747 | 18577-18583 | Protein | denotes | Ubc5hc |
T10746 | 18567-18572 | Protein | denotes | Ubc13 |
T10745 | 18404-18409 | Protein | denotes | MALT1 |
T10744 | 18394-18399 | Protein | denotes | TRAF6 |
T10743 | 18388-18392 | Protein | denotes | RIP2 |
T10742 | 18382-18386 | Protein | denotes | RIP1 |
T10741 | 18275-18278 | Protein | denotes | A20 |
T10740 | 18132-18135 | Protein | denotes | TNF |
T10739 | 18038-18043 | Protein | denotes | NF-κB |
T10738 | 17986-18011 | Protein | denotes | ubiquitin-editing protein |
T10737 | 17972-17979 | Protein | denotes | TNFAIP3 |
T10736 | 17953-17956 | Protein | denotes | A20 |
T10735 | 17941-17944 | Protein | denotes | A20 |
T8773 | 17781-17785 | Protein | denotes | IKK1 |
T8772 | 17680-17683 | Protein | denotes | NIK |
T8771 | 17660-17664 | Protein | denotes | IKK1 |
T8770 | 17596-17601 | Protein | denotes | STAT1 |
T8769 | 17480-17484 | Protein | denotes | IKK1 |
T8768 | 17457-17461 | Protein | denotes | IκBα |
T8767 | 17437-17441 | Protein | denotes | IKK2 |
T8766 | 17353-17357 | Protein | denotes | IKK1 |
T8765 | 17297-17301 | Protein | denotes | IKK1 |
T8764 | 17069-17073 | Protein | denotes | IKK1 |
T8763 | 16915-16921 | Protein | denotes | TOLLIP |
T8762 | 16903-16909 | Protein | denotes | IRAK-M |
T8761 | 16895-16901 | Protein | denotes | MyD88s |
T5900 | 15890-15894 | Protein | denotes | CD40 |
T5899 | 15850-15855 | Protein | denotes | TRAF3 |
T5898 | 15803-15808 | Protein | denotes | TRAF2 |
T5897 | 15780-15784 | Protein | denotes | IL-6 |
T5896 | 15747-15751 | Protein | denotes | CD40 |
T5895 | 15725-15730 | Protein | denotes | TRAF6 |
T5894 | 15676-15680 | Protein | denotes | CD40 |
T5893 | 15499-15504 | Protein | denotes | TRAF3 |
T5892 | 15489-15494 | Protein | denotes | TRAF2 |
T5891 | 15440-15445 | Protein | denotes | TRAF6 |
T5890 | 15429-15434 | Protein | denotes | TRAF5 |
T5889 | 15422-15427 | Protein | denotes | TRAF3 |
T5888 | 15415-15420 | Protein | denotes | TRAF2 |
T5887 | 15408-15413 | Protein | denotes | TRAF1 |
T5886 | 15357-15361 | Protein | denotes | RANK |
T5885 | 15348-15352 | Protein | denotes | CD40 |
T5884 | 15228-15232 | Protein | denotes | RANK |
T5883 | 15201-15223 | Protein | denotes | lymphotoxin β receptor |
T5882 | 15195-15199 | Protein | denotes | CD40 |
T5881 | 13798-13802 | Protein | denotes | IKK1 |
T5880 | 13777-13780 | Protein | denotes | NIK |
T5879 | 13725-13728 | Protein | denotes | NIK |
T5878 | 13672-13677 | Protein | denotes | TRAF3 |
T5877 | 13634-13635 | Protein | denotes | 2 |
T5876 | 13628-13633 | Protein | denotes | cIAP1 |
T5875 | 13618-13623 | Protein | denotes | TRAF2 |
T5874 | 13540-13545 | Protein | denotes | TRAF3 |
T5873 | 13426-13429 | Protein | denotes | NIK |
T5872 | 13395-13396 | Protein | denotes | 2 |
T5871 | 13389-13394 | Protein | denotes | cIAP1 |
T5870 | 13378-13383 | Protein | denotes | TRAF3 |
T5869 | 13371-13376 | Protein | denotes | TRAF2 |
T5868 | 13330-13333 | Protein | denotes | NIK |
T5867 | 13185-13188 | Protein | denotes | NIK |
T5866 | 13179-13182 | Protein | denotes | NIK |
T5865 | 13156-13177 | Protein | denotes | NF-κB inducing kinase |
T5864 | 13107-13111 | Protein | denotes | IKK1 |
T5863 | 12892-12896 | Protein | denotes | RelB |
T5862 | 12863-12866 | Protein | denotes | p52 |
T5861 | 12824-12828 | Protein | denotes | p100 |
T5860 | 12790-12794 | Protein | denotes | RANK |
T5859 | 12780-12784 | Protein | denotes | CD40 |
T5858 | 12765-12778 | Protein | denotes | BAFF receptor |
T5857 | 12741-12763 | Protein | denotes | lymphotoxin β receptor |
T5856 | 12662-12665 | Protein | denotes | TNF |
T5855 | 12597-12601 | Protein | denotes | TAK1 |
T5854 | 12533-12537 | Protein | denotes | RIP1 |
T5853 | 12518-12523 | Protein | denotes | TRAF6 |
T5852 | 12499-12503 | Protein | denotes | TRIF |
T5851 | 12487-12492 | Protein | denotes | TRAF6 |
T5850 | 12427-12432 | Protein | denotes | TRAF6 |
T5849 | 12347-12352 | Protein | denotes | MyD88 |
T5848 | 12326-12330 | Protein | denotes | TRIF |
T5847 | 12281-12324 | Protein | denotes | TIR domain-containing adaptor-inducing IFNβ |
T5846 | 12270-12275 | Protein | denotes | MyD88 |
T5845 | 12220-12268 | Protein | denotes | myeloid differentiation primary response gene 88 |
T5844 | 12156-12160 | Protein | denotes | TRAM |
T5843 | 12125-12154 | Protein | denotes | TRIF-related adaptor molecule |
T5842 | 12116-12118 | Protein | denotes | Ma |
T5841 | 12060-12094 | Protein | denotes | Toll/IL-1 receptor adaptor protein |
T5840 | 11994-11998 | Protein | denotes | TLR4 |
T5839 | 11906-11910 | Protein | denotes | TAK1 |
T5838 | 11680-11683 | Protein | denotes | TNF |
T5837 | 11621-11625 | Protein | denotes | NEMO |
T5836 | 11529-11530 | Protein | denotes | 2 |
T5835 | 11524-11528 | Protein | denotes | TAB1 |
T5834 | 11515-11519 | Protein | denotes | NEMO |
T5833 | 11467-11471 | Protein | denotes | TAK1 |
T5832 | 11405-11409 | Protein | denotes | RIP1 |
T5831 | 11308-11312 | Protein | denotes | RIP1 |
T5830 | 11282-11283 | Protein | denotes | 2 |
T5829 | 11276-11281 | Protein | denotes | cIAP1 |
T5828 | 11270-11271 | Protein | denotes | 5 |
T5827 | 11264-11269 | Protein | denotes | TRAF2 |
T5826 | 11203-11207 | Protein | denotes | RIP1 |
T5825 | 11167-11170 | Protein | denotes | TNF |
T5824 | 11146-11151 | Protein | denotes | cIAP2 |
T5823 | 11101-11141 | Protein | denotes | cellular inhibitor of apoptosis (cIAP) 1 |
T5822 | 11050-11055 | Protein | denotes | TRAF5 |
T5821 | 11006-11045 | Protein | denotes | TNF receptor-associated factor (TRAF) 2 |
T5820 | 10935-10939 | Protein | denotes | RIP1 |
T5819 | 10903-10933 | Protein | denotes | receptor interacting protein 1 |
T5818 | 10881-10886 | Protein | denotes | TRADD |
T5817 | 10841-10879 | Protein | denotes | TNF receptor-1-associated death domain |
T5816 | 10795-10798 | Protein | denotes | TNF |
T5815 | 10782-10785 | Protein | denotes | TNF |
T5814 | 8474-8478 | Protein | denotes | IKK1 |
T5813 | 8460-8464 | Protein | denotes | NEMO |
T5812 | 8451-8455 | Protein | denotes | IKK2 |
T5811 | 8394-8398 | Protein | denotes | IKKγ |
T5810 | 8373-8377 | Protein | denotes | NEMO |
T5809 | 8346-8371 | Protein | denotes | NF-κB essential modulator |
T5808 | 8313-8317 | Protein | denotes | IKKβ |
T5807 | 8304-8308 | Protein | denotes | IKKα |
T5806 | 8284-8288 | Protein | denotes | IKK2 |
T5805 | 8275-8279 | Protein | denotes | IKK1 |
T5804 | 7830-7835 | Protein | denotes | RANKL |
T5803 | 7808-7811 | Protein | denotes | TNF |
T5802 | 7481-7484 | Protein | denotes | p50 |
T5801 | 7473-7476 | Protein | denotes | p52 |
T5800 | 7446-7450 | Protein | denotes | p105 |
T5799 | 7437-7441 | Protein | denotes | p100 |
T5798 | 7374-7379 | Protein | denotes | Bcl-3 |
T5797 | 7365-7369 | Protein | denotes | IκBξ |
T5796 | 7326-7332 | Protein | denotes | NF-κB2 |
T5795 | 7306-7310 | Protein | denotes | p100 |
T5794 | 7297-7303 | Protein | denotes | NF-κB1 |
T5793 | 7277-7281 | Protein | denotes | p105 |
T5792 | 7271-7275 | Protein | denotes | IκBε |
T5791 | 7265-7269 | Protein | denotes | IκBβ |
T5790 | 7259-7263 | Protein | denotes | IκBα |
T2603 | 6759-6769 | Protein | denotes | tenascin C |
T2602 | 6749-6757 | Protein | denotes | biglycan |
T2601 | 6736-6747 | Protein | denotes | fibronectin |
T2600 | 6565-6569 | Protein | denotes | TLR4 |
T2599 | 6341-6367 | Protein | denotes | myeloid-related protein 14 |
T2598 | 6311-6336 | Protein | denotes | Myeloid-related protein 8 |
T2597 | 6248-6253 | Protein | denotes | HMGB1 |
T2596 | 6183-6188 | Protein | denotes | HMGB1 |
T2595 | 6138-6143 | Protein | denotes | HMGB1 |
T2594 | 6099-6111 | Protein | denotes | TLR4 ligands |
T2593 | 5954-5973 | Protein | denotes | chromatin component |
T2592 | 5927-5932 | Protein | denotes | HMGB1 |
T2591 | 5880-5925 | Protein | denotes | High mobility group box chromosomal protein 1 |
T2590 | 5011-5033 | Protein | denotes | lymphotoxin β receptor |
T2589 | 4957-4961 | Protein | denotes | BAFF |
T2588 | 4836-4840 | Protein | denotes | BAFF |
T2587 | 4810-4834 | Protein | denotes | B-cell activating factor |
T2586 | 4576-4580 | Protein | denotes | CD40 |
T2585 | 4302-4305 | Protein | denotes | CD4 |
T2584 | 4235-4240 | Protein | denotes | CD154 |
T2583 | 4222-4233 | Protein | denotes | CD40 ligand |
T2582 | 4197-4200 | Protein | denotes | TNF |
T2581 | 3919-3945 | Protein | denotes | TNF receptor family member |
T2580 | 3903-3907 | Protein | denotes | CD40 |
T2579 | 3789-3793 | Protein | denotes | RANK |
T2578 | 3693-3697 | Protein | denotes | RANK |
T2577 | 3664-3691 | Protein | denotes | receptor activator of NF-κB |
T2576 | 3450-3453 | Protein | denotes | TNF |
T2575 | 3375-3378 | Protein | denotes | TNF |
T2574 | 3316-3319 | Protein | denotes | TNF |
T831 | 2966-2971 | Protein | denotes | c-REL |
T830 | 2953-2960 | Protein | denotes | TNFAIP3 |
T829 | 2946-2951 | Protein | denotes | TRAF1 |
T828 | 2940-2944 | Protein | denotes | CD40 |
T827 | 2690-2695 | Protein | denotes | RANKL |
T826 | 2654-2688 | Protein | denotes | receptor activator of NF-κB ligand |
T825 | 2035-2038 | Protein | denotes | TNF |
T824 | 1932-1963 | Protein | denotes | inducible nitric oxide synthase |
T823 | 1901-1918 | Protein | denotes | cyclo-oxygenase-2 |
T822 | 1895-1899 | Protein | denotes | IL-6 |
T821 | 1884-1887 | Protein | denotes | TNF |
T820 | 1758-1763 | Protein | denotes | c-Rel |
T819 | 1752-1756 | Protein | denotes | RelB |
T818 | 1746-1750 | Protein | denotes | RelA |
T817 | 1739-1742 | Protein | denotes | p65 |
T816 | 1731-1737 | Protein | denotes | NF-κB1 |
T815 | 1723-1727 | Protein | denotes | p105 |
T814 | 1715-1721 | Protein | denotes | NF-κB2 |
T813 | 1707-1711 | Protein | denotes | p100 |
BioNLP16_DUT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T22376 | 14102-14107 | Protein | denotes | cIAP1 |
T22375 | 14092-14097 | Protein | denotes | TRAF3 |
T22374 | 14085-14090 | Protein | denotes | TRAF2 |
T22373 | 14028-14031 | Protein | denotes | NIK |
T22372 | 14207-14210 | Protein | denotes | NIK |
T22371 | 14194-14197 | Protein | denotes | NIK |
T22370 | 13982-13985 | Protein | denotes | NIK |
T22369 | 13959-13980 | Protein | denotes | NF-κB inducing kinase |
T22368 | 13889-13893 | Protein | denotes | RANK |
T22367 | 13880-13884 | Protein | denotes | CD40 |
T22418 | 14740-14751 | Protein_catabolism | denotes | degradation |
T22417 | 14649-14664 | Phosphorylation | denotes | phosphorylation |
T22416 | 14607-14616 | Positive_regulation | denotes | activates |
T22415 | 14588-14602 | Phosphorylation | denotes | phosphorylates |
T22414 | 14629-14637 | Positive_regulation | denotes | mediates |
T22413 | 14532-14541 | Positive_regulation | denotes | resulting |
T22412 | 14483-14489 | Positive_regulation | denotes | result |
T22411 | 14500-14508 | Protein_catabolism | denotes | degraded |
T22410 | 14545-14554 | Positive_regulation | denotes | increased |
T22409 | 14520-14530 | Positive_regulation | denotes | stabilised |
T22408 | 14432-14450 | Binding | denotes | polyubiquitination |
T22407 | 14253-14262 | Binding | denotes | recruited |
T22406 | 14326-14344 | Binding | denotes | polyubiquitination |
T22405 | 14144-14162 | Binding | denotes | polyubiquitination |
T22404 | 14179-14190 | Protein_catabolism | denotes | degradation |
T22403 | 14117-14128 | Positive_regulation | denotes | facilitates |
T22402 | 13946-13955 | Regulation | denotes | dependent |
T22401 | 13987-13997 | Gene_expression | denotes | expression |
T22400 | 15143-15165 | Protein | denotes | tumour necrosis factor |
T22399 | 15138-15141 | Protein | denotes | TNF |
T22398 | 15071-15098 | Protein | denotes | receptor activator of NF-κB |
T22397 | 15065-15069 | Protein | denotes | RANK |
T22396 | 14846-14851 | Protein | denotes | TRAF1 |
T22395 | 14839-14844 | Protein | denotes | TRAF3 |
T22394 | 14799-14803 | Protein | denotes | RelB |
T22393 | 14763-14766 | Protein | denotes | p52 |
T22392 | 14755-14759 | Protein | denotes | p100 |
T22391 | 14644-14648 | Protein | denotes | p100 |
T22390 | 14617-14621 | Protein | denotes | IKK1 |
T22389 | 14579-14582 | Protein | denotes | NIK |
T22388 | 14555-14558 | Protein | denotes | NIK |
T22387 | 14513-14516 | Protein | denotes | NIK |
T22386 | 14491-14496 | Protein | denotes | TRAF3 |
T22385 | 14473-14476 | Protein | denotes | NIK |
T22384 | 14454-14459 | Protein | denotes | TRAF3 |
T22383 | 14407-14408 | Protein | denotes | 2 |
T22382 | 14401-14406 | Protein | denotes | cIAP1 |
T22381 | 14354-14355 | Protein | denotes | 2 |
T22380 | 14348-14353 | Protein | denotes | cIAP1 |
T22379 | 14286-14291 | Protein | denotes | TRAF2 |
T22378 | 14244-14249 | Protein | denotes | TRAF3 |
T22377 | 14108-14109 | Protein | denotes | 2 |
T21070 | 10010-10017 | Binding | denotes | binding |
T21069 | 9988-9995 | Binding | denotes | compete |
T21068 | 9836-9846 | Negative_regulation | denotes | inhibiting |
T21067 | 9847-9857 | Gene_expression | denotes | expression |
T21066 | 9609-9618 | Binding | denotes | targeting |
T21065 | 9306-9317 | Binding | denotes | heterodimer |
T21064 | 9180-9194 | Phosphorylation | denotes | phosphorylates |
T21063 | 9131-9145 | Phosphorylation | denotes | phosphorylates |
T21062 | 9150-9159 | Positive_regulation | denotes | activates |
T21061 | 8961-8979 | Binding | denotes | polyubiquitination |
T21060 | 9079-9089 | Positive_regulation | denotes | activation |
T21059 | 9063-9074 | Binding | denotes | recruitment |
T21058 | 8599-8609 | Binding | denotes | engagement |
T21057 | 8677-8684 | Positive_regulation | denotes | trigger |
T21056 | 8689-8700 | Binding | denotes | recruitment |
T21055 | 10701-10723 | Protein | denotes | tumour necrosis factor |
T21054 | 10696-10699 | Protein | denotes | TNF |
T21053 | 10558-10600 | Protein | denotes | single-immunoglobulinIL-1 receptor-related |
T21052 | 10550-10556 | Protein | denotes | SIGIRR |
T21051 | 10518-10548 | Protein | denotes | receptor interacting protein 1 |
T21050 | 10512-10516 | Protein | denotes | RIP1 |
T21049 | 10483-10510 | Protein | denotes | receptor activator of NF-κB |
T21048 | 10477-10481 | Protein | denotes | RANK |
T21047 | 10430-10455 | Protein | denotes | NF-κB essential modulator |
T21046 | 10424-10428 | Protein | denotes | NEMO |
T21045 | 10374-10422 | Protein | denotes | myeloid differentiation primary response gene 88 |
T21044 | 10367-10372 | Protein | denotes | MyD88 |
T21043 | 10277-10292 | Protein | denotes | cylindromatosis |
T21042 | 10271-10275 | Protein | denotes | CYLD |
T21041 | 10200-10230 | Protein | denotes | A20-binding inhibitor of NF-κB |
T21040 | 10194-10198 | Protein | denotes | ABIN |
T21039 | 10031-10036 | Protein | denotes | TRAF6 |
T21038 | 10021-10026 | Protein | denotes | IRAK1 |
T21037 | 10001-10005 | Protein | denotes | TLR4 |
T21036 | 9953-9959 | Protein | denotes | SIGIRR |
T21035 | 9871-9876 | Protein | denotes | TRAF6 |
T21034 | 9861-9866 | Protein | denotes | IRAK1 |
T21033 | 9771-9774 | Protein | denotes | p62 |
T21032 | 9760-9766 | Protein | denotes | ABIN-1 |
T21031 | 9667-9672 | Protein | denotes | TRAF6 |
T21030 | 9658-9662 | Protein | denotes | RIP1 |
T21029 | 9542-9546 | Protein | denotes | CYLD |
T18774 | 31237-31250 | Gene_expression | denotes | overexpressed |
T18773 | 31067-31076 | Gene_expression | denotes | expressed |
T18772 | 30786-30801 | Regulation | denotes | NF-κB-dependent |
T18771 | 32659-32666 | Protein | denotes | miR-223 |
T18770 | 32646-32653 | Protein | denotes | miR-132 |
T18769 | 32638-32644 | Protein | denotes | miR-16 |
T18768 | 32575-32579 | Protein | denotes | IL-6 |
T18767 | 32544-32570 | Protein | denotes | matrix metalloproteinase-1 |
T18766 | 32500-32507 | Protein | denotes | miR-203 |
T18765 | 32368-32402 | Protein | denotes | monocyte chemoattractant protein 1 |
T18764 | 32324-32332 | Protein | denotes | miR-124a |
T18763 | 32152-32159 | Protein | denotes | miR-155 |
T18762 | 31754-31761 | Protein | denotes | miR-155 |
T18761 | 31680-31683 | Protein | denotes | TNF |
T18760 | 31651-31658 | Protein | denotes | miR-155 |
T18759 | 31450-31457 | Protein | denotes | miR-155 |
T18758 | 31364-31372 | Protein | denotes | miR-146a |
T18757 | 31263-31268 | Protein | denotes | IL-17 |
T18756 | 31254-31257 | Protein | denotes | CD4 |
T18755 | 31220-31228 | Protein | denotes | miR-146a |
T18754 | 31055-31062 | Protein | denotes | miR-155 |
T18753 | 31015-31019 | Protein | denotes | RIP1 |
T18752 | 31006-31010 | Protein | denotes | IKKε |
T18751 | 30931-30938 | Protein | denotes | miR-155 |
T18750 | 30894-30902 | Protein | denotes | miR-146a |
T18749 | 30853-30858 | Protein | denotes | TRAF6 |
T18748 | 30843-30848 | Protein | denotes | IRAK1 |
T18747 | 30771-30779 | Protein | denotes | miR-146a |
T18746 | 30736-30739 | Protein | denotes | TNF |
T18745 | 30729-30734 | Protein | denotes | IL-1β |
T18744 | 30590-30597 | Protein | denotes | miR-155 |
T18743 | 30584-30585 | Protein | denotes | b |
T18742 | 30575-30583 | Protein | denotes | miR-146a |
T17215 | 30171-30182 | Binding | denotes | association |
T17214 | 29720-29727 | Binding | denotes | recruit |
T17213 | 29761-29769 | Binding | denotes | interact |
T17212 | 29639-29646 | Binding | denotes | binding |
T17211 | 29336-29345 | Negative_regulation | denotes | deficient |
T17210 | 29128-29137 | Negative_regulation | denotes | deficient |
T17209 | 29038-29047 | Positive_regulation | denotes | inducible |
T17208 | 29059-29073 | Gene_expression | denotes | overexpression |
T17207 | 29015-29025 | Gene_expression | denotes | Expression |
T17206 | 29059-29073 | Positive_regulation | denotes | overexpression |
T17205 | 30190-30195 | Protein | denotes | TRAF1 |
T17204 | 30057-30062 | Protein | denotes | TRAF1 |
T17203 | 29955-29960 | Protein | denotes | TRAF1 |
T17202 | 29728-29731 | Protein | denotes | A20 |
T17201 | 29708-29713 | Protein | denotes | TRAF1 |
T17200 | 29595-29600 | Protein | denotes | TRAF1 |
T17199 | 29528-29533 | Protein | denotes | TRAF1 |
T17198 | 29426-29431 | Protein | denotes | TRAF2 |
T17197 | 29330-29335 | Protein | denotes | TRAF1 |
T17196 | 29299-29303 | Protein | denotes | CD40 |
T17195 | 29251-29256 | Protein | denotes | TRAF1 |
T17194 | 29122-29127 | Protein | denotes | TRAF1 |
T17193 | 29170-29173 | Protein | denotes | TNF |
T17192 | 29092-29095 | Protein | denotes | TNF |
T17191 | 29077-29082 | Protein | denotes | TRAF1 |
T17190 | 29051-29054 | Protein | denotes | TNF |
T17189 | 29029-29034 | Protein | denotes | TRAF1 |
T17188 | 28862-28867 | Protein | denotes | TRAF1 |
T17187 | 28798-28807 | Protein | denotes | ubiquitin |
T17186 | 28688-28693 | Protein | denotes | TRAF1 |
T17185 | 28655-28687 | Protein | denotes | TNF receptor-associated factor 1 |
T16200 | 28574-28584 | Gene_expression | denotes | expression |
T16199 | 28640-28646 | Regulation | denotes | target |
T16198 | 28391-28401 | Gene_expression | denotes | expression |
T16197 | 28219-28228 | Negative_regulation | denotes | deficient |
T16196 | 28026-28040 | Positive_regulation | denotes | overexpression |
T16195 | 28026-28040 | Gene_expression | denotes | overexpression |
T16194 | 27898-27907 | Gene_expression | denotes | expressed |
T16193 | 27616-27627 | Binding | denotes | interaction |
T16192 | 27553-27562 | Negative_regulation | denotes | inhibitor |
T16191 | 28594-28600 | Protein | denotes | SIGIRR |
T16190 | 28510-28516 | Protein | denotes | SIGIRR |
T16189 | 28405-28411 | Protein | denotes | SIGIRR |
T16188 | 28212-28218 | Protein | denotes | SIGIRR |
T16187 | 28168-28174 | Protein | denotes | SIGIRR |
T16186 | 28019-28025 | Protein | denotes | SIGIRR |
T16185 | 27843-27849 | Protein | denotes | SIGIRR |
T16184 | 27717-27722 | Protein | denotes | IL-1R |
T16183 | 27813-27819 | Protein | denotes | SIGIRR |
T16182 | 27666-27671 | Protein | denotes | TRAF6 |
T16181 | 27657-27662 | Protein | denotes | IRAK1 |
T16180 | 27650-27655 | Protein | denotes | MyD88 |
T16179 | 27566-27571 | Protein | denotes | IL-1R |
T16178 | 27464-27469 | Protein | denotes | TIR-8 |
T16177 | 27433-27439 | Protein | denotes | SIGIRR |
T16176 | 27388-27431 | Protein | denotes | Single-immunoglobulin IL-1 receptor-related |
T16175 | 27336-27379 | Protein | denotes | Single-immunoglobulin IL-1 receptor-related |
T15301 | 26964-26974 | Gene_expression | denotes | expressing |
T15300 | 26635-26645 | Gene_expression | denotes | expression |
T15299 | 26781-26788 | Binding | denotes | binding |
T15298 | 26876-26892 | Negative_regulation | denotes | deubiquitination |
T15297 | 26658-26669 | Positive_regulation | denotes | upregulated |
T15296 | 26406-26416 | Negative_regulation | denotes | deficiency |
T15295 | 25997-26006 | Gene_expression | denotes | expressed |
T15294 | 25872-25880 | Binding | denotes | targeted |
T15293 | 27244-27248 | Protein | denotes | CYLD |
T15292 | 27135-27139 | Protein | denotes | RANK |
T15291 | 27106-27110 | Protein | denotes | CYLD |
T15290 | 26993-26996 | Protein | denotes | p62 |
T15289 | 26896-26901 | Protein | denotes | TRAF6 |
T15288 | 26862-26866 | Protein | denotes | CYLD |
T15287 | 26824-26838 | Protein | denotes | sequestosome 1 |
T15286 | 26805-26808 | Protein | denotes | p62 |
T15285 | 26771-26780 | Protein | denotes | ubiquitin |
T15284 | 26757-26762 | Protein | denotes | TRAF6 |
T15283 | 26690-26695 | Protein | denotes | RANKL |
T15282 | 26630-26634 | Protein | denotes | CYLD |
T15281 | 26559-26564 | Protein | denotes | RANKL |
T15280 | 26420-26424 | Protein | denotes | CYLD |
T15279 | 26333-26337 | Protein | denotes | RANK |
T15278 | 26290-26294 | Protein | denotes | CYLD |
T15277 | 26143-26147 | Protein | denotes | CYLD |
T15276 | 25985-25988 | Protein | denotes | A20 |
T15275 | 25948-25952 | Protein | denotes | CYLD |
T15274 | 25933-25936 | Protein | denotes | A20 |
T15273 | 25884-25887 | Protein | denotes | A20 |
T15272 | 25813-25818 | Protein | denotes | TRAF2 |
T15271 | 25807-25811 | Protein | denotes | NEMO |
T15270 | 25674-25678 | Protein | denotes | RANK |
T15269 | 25588-25611 | Protein | denotes | deubiquitinating enzyme |
T15268 | 25578-25582 | Protein | denotes | CYLD |
T15267 | 25843-25847 | Protein | denotes | TAK1 |
T15266 | 25834-25838 | Protein | denotes | RIP1 |
T15265 | 25827-25832 | Protein | denotes | TRAF7 |
T15264 | 25820-25825 | Protein | denotes | TRAF6 |
T15263 | 25385-25389 | Protein | denotes | CYLD |
T15262 | 25279-25283 | Protein | denotes | CYLD |
T15261 | 25262-25277 | Protein | denotes | Cylindromatosis |
T15260 | 25238-25253 | Protein | denotes | Cylindromatosis |
T13888 | 24468-24474 | Regulation | denotes | depend |
T13887 | 24482-24492 | Gene_expression | denotes | expression |
T13886 | 24080-24087 | Positive_regulation | denotes | induced |
T13885 | 24126-24132 | Transcription | denotes | levels |
T13884 | 23922-23931 | Negative_regulation | denotes | deficient |
T13883 | 23752-23759 | Gene_expression | denotes | express |
T13882 | 23717-23726 | Gene_expression | denotes | expressed |
T13881 | 23502-23511 | Negative_regulation | denotes | deficient |
T13880 | 23523-23532 | Negative_regulation | denotes | deficient |
T13879 | 23315-23325 | Gene_expression | denotes | expression |
T13878 | 23370-23374 | Positive_regulation | denotes | role |
T13877 | 23229-23235 | Binding | denotes | target |
T13876 | 23013-23024 | Binding | denotes | interacting |
T13875 | 22999-23008 | Gene_expression | denotes | expressed |
T13874 | 22870-22877 | Binding | denotes | binding |
T13873 | 24679-24685 | Protein | denotes | ABIN-1 |
T13872 | 24537-24540 | Protein | denotes | A20 |
T13871 | 24526-24532 | Protein | denotes | ABIN-3 |
T13870 | 24239-24242 | Protein | denotes | A20 |
T13869 | 24217-24223 | Protein | denotes | ABIN-1 |
T13868 | 24136-24142 | Protein | denotes | ABIN-1 |
T13867 | 24076-24079 | Protein | denotes | TNF |
T13866 | 24048-24054 | Protein | denotes | ABIN-1 |
T13865 | 23962-23965 | Protein | denotes | TNF |
T13864 | 23915-23921 | Protein | denotes | ABIN-1 |
T13863 | 23883-23886 | Protein | denotes | TNF |
T13862 | 23853-23859 | Protein | denotes | ABIN-1 |
T13861 | 23848-23851 | Protein | denotes | A20 |
T13860 | 23762-23789 | Protein | denotes | truncated and inactive form |
T13859 | 23707-23713 | Protein | denotes | ABIN-3 |
T13858 | 23516-23522 | Protein | denotes | ABIN-2 |
T13857 | 23495-23501 | Protein | denotes | ABIN-1 |
T13856 | 23383-23386 | Protein | denotes | A20 |
T13855 | 23308-23314 | Protein | denotes | ABIN-3 |
T13854 | 23297-23303 | Protein | denotes | ABIN-1 |
T13853 | 23292-23295 | Protein | denotes | A20 |
T13852 | 23236-23239 | Protein | denotes | A20 |
T13851 | 23080-23083 | Protein | denotes | TNF |
T13850 | 23009-23012 | Protein | denotes | A20 |
T13849 | 22959-22965 | Protein | denotes | TNIP-3 |
T13848 | 22947-22953 | Protein | denotes | TNIP-2 |
T13847 | 22939-22945 | Protein | denotes | TNIP-1 |
T13846 | 22917-22923 | Protein | denotes | ABIN-3 |
T13845 | 22906-22912 | Protein | denotes | ABIN-2 |
T13844 | 22898-22904 | Protein | denotes | ABIN-1 |
T13843 | 22866-22869 | Protein | denotes | A20 |
T12275 | 22545-22554 | Negative_regulation | denotes | repressed |
T12274 | 22559-22572 | Transcription | denotes | transcription |
T12273 | 22313-22319 | Regulation | denotes | affect |
T12272 | 22155-22162 | Positive_regulation | denotes | induced |
T12271 | 22123-22131 | Positive_regulation | denotes | required |
T12270 | 21972-21981 | Regulation | denotes | influence |
T12269 | 21791-21802 | Binding | denotes | association |
T12268 | 21456-21460 | Negative_regulation | denotes | lack |
T12267 | 21166-21180 | Positive_regulation | denotes | overexpression |
T12266 | 21166-21180 | Gene_expression | denotes | overexpression |
T12265 | 21017-21027 | Gene_expression | denotes | transduced |
T12264 | 20970-20979 | Negative_regulation | denotes | decreased |
T12263 | 20503-20513 | Gene_expression | denotes | expression |
T12262 | 20836-20846 | Gene_expression | denotes | expression |
T12261 | 20553-20563 | Negative_regulation | denotes | inhibition |
T12260 | 20586-20595 | Negative_regulation | denotes | decreased |
T12259 | 20275-20285 | Gene_expression | denotes | expressing |
T12258 | 20131-20140 | Regulation | denotes | regulated |
T12257 | 20110-20120 | Gene_expression | denotes | expression |
T12256 | 19933-19943 | Gene_expression | denotes | expression |
T12255 | 19790-19797 | Negative_regulation | denotes | lacking |
T12254 | 19475-19482 | Negative_regulation | denotes | lacking |
T12253 | 19315-19324 | Negative_regulation | denotes | deficient |
T12252 | 19130-19139 | Negative_regulation | denotes | deficient |
T12251 | 19066-19075 | Regulation | denotes | regulates |
T12250 | 18985-18994 | Negative_regulation | denotes | inhibitor |
T12249 | 18774-18782 | Positive_regulation | denotes | requires |
T12248 | 18766-18773 | Regulation | denotes | targets |
T12247 | 18738-18749 | Binding | denotes | association |
T12246 | 18498-18508 | Negative_regulation | denotes | disruption |
T12245 | 18512-18524 | Binding | denotes | interactions |
T12244 | 18451-18463 | Binding | denotes | interactions |
T12243 | 18028-18037 | Regulation | denotes | regulates |
T12242 | 22791-22794 | Protein | denotes | A20 |
T12241 | 22555-22558 | Protein | denotes | A20 |
T12240 | 22507-22510 | Protein | denotes | A20 |
T12239 | 22327-22330 | Protein | denotes | A20 |
T12238 | 22246-22249 | Protein | denotes | A20 |
T12237 | 22208-22216 | Protein | denotes | cytokine |
T12236 | 22176-22179 | Protein | denotes | TNF |
T12235 | 22151-22154 | Protein | denotes | TNF |
T12234 | 22116-22119 | Protein | denotes | A20 |
T12233 | 22029-22032 | Protein | denotes | A20 |
T12232 | 21982-21985 | Protein | denotes | A20 |
T12231 | 21828-21831 | Protein | denotes | A20 |
T12230 | 21607-21610 | Protein | denotes | A20 |
T12229 | 21461-21464 | Protein | denotes | A20 |
T12228 | 21257-21260 | Protein | denotes | A20 |
T12227 | 21162-21165 | Protein | denotes | A20 |
T12226 | 21013-21016 | Protein | denotes | A20 |
T12225 | 21004-21009 | Protein | denotes | IL-1β |
T12224 | 20996-20999 | Protein | denotes | TNF |
T12223 | 20869-20874 | Protein | denotes | IL-1β |
T12222 | 20861-20864 | Protein | denotes | TNF |
T12221 | 20703-20706 | Protein | denotes | A20 |
T12220 | 20639-20674 | Protein | denotes | monocyte chemo-attractant protein 1 |
T12219 | 20632-20637 | Protein | denotes | RANKL |
T12218 | 20618-20622 | Protein | denotes | IL-6 |
T12217 | 20611-20616 | Protein | denotes | IL-1β |
T12216 | 20606-20609 | Protein | denotes | TNF |
T12215 | 20499-20502 | Protein | denotes | A20 |
T12214 | 20271-20274 | Protein | denotes | A20 |
T12213 | 20168-20171 | Protein | denotes | A20 |
T12212 | 20106-20109 | Protein | denotes | A20 |
T12211 | 19929-19932 | Protein | denotes | A20 |
T12210 | 19798-19801 | Protein | denotes | A20 |
T12209 | 19677-19680 | Protein | denotes | A20 |
T12208 | 19643-19646 | Protein | denotes | TNF |
T12207 | 19483-19486 | Protein | denotes | A20 |
T12206 | 19360-19363 | Protein | denotes | TNF |
T12205 | 19311-19314 | Protein | denotes | A20 |
T12204 | 19126-19129 | Protein | denotes | A20 |
T12203 | 19062-19065 | Protein | denotes | A20 |
T12202 | 18964-18967 | Protein | denotes | A20 |
T12201 | 18882-18904 | Protein | denotes | Tax1-binding protein 1 |
T12200 | 18838-18877 | Protein | denotes | A20-binding inhibitor of NF-κB (ABIN) 1 |
T12199 | 18753-18756 | Protein | denotes | A20 |
T12198 | 18691-18694 | Protein | denotes | A20 |
T12197 | 18634-18635 | Protein | denotes | 2 |
T12196 | 18628-18633 | Protein | denotes | cIAP1 |
T12195 | 18618-18623 | Protein | denotes | TRAF2 |
T12194 | 18611-18616 | Protein | denotes | TRAF6 |
T12193 | 18577-18583 | Protein | denotes | Ubc5hc |
T12192 | 18567-18572 | Protein | denotes | Ubc13 |
T12191 | 18388-18392 | Protein | denotes | RIP2 |
T12190 | 18382-18386 | Protein | denotes | RIP1 |
T12189 | 18275-18278 | Protein | denotes | A20 |
T12188 | 18404-18409 | Protein | denotes | MALT1 |
T12187 | 18394-18399 | Protein | denotes | TRAF6 |
T12186 | 18132-18135 | Protein | denotes | TNF |
T12185 | 18038-18043 | Protein | denotes | NF-κB |
T12184 | 17986-18011 | Protein | denotes | ubiquitin-editing protein |
T12183 | 17972-17979 | Protein | denotes | TNFAIP3 |
T12182 | 17953-17956 | Protein | denotes | A20 |
T12181 | 17941-17944 | Protein | denotes | A20 |
T9289 | 17665-17679 | Phosphorylation | denotes | phosphorylates |
T9288 | 17580-17595 | Phosphorylation | denotes | phosphorylating |
T9287 | 17428-17436 | Positive_regulation | denotes | enhanced |
T9286 | 17462-17473 | Protein_catabolism | denotes | degradation |
T9285 | 17418-17424 | Positive_regulation | denotes | result |
T9284 | 17333-17343 | Gene_expression | denotes | expressing |
T9283 | 17442-17452 | Positive_regulation | denotes | activation |
T9282 | 17302-17311 | Negative_regulation | denotes | deficient |
T9281 | 17781-17785 | Protein | denotes | IKK1 |
T9280 | 17680-17683 | Protein | denotes | NIK |
T9279 | 17660-17664 | Protein | denotes | IKK1 |
T9278 | 17480-17484 | Protein | denotes | IKK1 |
T9277 | 17596-17601 | Protein | denotes | STAT1 |
T9276 | 17457-17461 | Protein | denotes | IκBα |
T9275 | 17437-17441 | Protein | denotes | IKK2 |
T9274 | 17353-17357 | Protein | denotes | IKK1 |
T9273 | 17297-17301 | Protein | denotes | IKK1 |
T9272 | 17069-17073 | Protein | denotes | IKK1 |
T9271 | 16915-16921 | Protein | denotes | TOLLIP |
T9270 | 16903-16909 | Protein | denotes | IRAK-M |
T9269 | 16895-16901 | Protein | denotes | MyD88s |
T7967 | 15785-15795 | Gene_expression | denotes | production |
T7966 | 15734-15742 | Positive_regulation | denotes | required |
T7965 | 15812-15820 | Positive_regulation | denotes | required |
T7964 | 15362-15370 | Binding | denotes | interact |
T7963 | 15469-15480 | Protein_catabolism | denotes | proteolysis |
T7962 | 13803-13818 | Phosphorylation | denotes | phosphorylation |
T7961 | 13715-13724 | Localization | denotes | releasing |
T7960 | 13751-13762 | Protein_catabolism | denotes | degradation |
T7959 | 13764-13773 | Positive_regulation | denotes | resulting |
T7958 | 13781-13793 | Positive_regulation | denotes | accumulation |
T7957 | 13647-13656 | Positive_regulation | denotes | essential |
T7956 | 13533-13539 | Negative_regulation | denotes | remove |
T7955 | 13678-13689 | Protein_catabolism | denotes | degradation |
T7954 | 13610-13617 | Binding | denotes | attract |
T7953 | 13358-13365 | Binding | denotes | complex |
T7952 | 13404-13425 | Positive_regulation | denotes | K48-polyubiquitinates |
T7951 | 13431-13438 | Positive_regulation | denotes | leading |
T7950 | 13457-13468 | Protein_catabolism | denotes | degradation |
T7949 | 13206-13215 | Regulation | denotes | regulated |
T7948 | 13122-13131 | Positive_regulation | denotes | activated |
T7947 | 12911-12920 | Regulation | denotes | regulates |
T7946 | 12588-12596 | Positive_regulation | denotes | activate |
T7945 | 12556-12567 | Binding | denotes | interaction |
T7944 | 12509-12517 | Binding | denotes | recruits |
T7943 | 11999-12010 | Positive_regulation | denotes | stimulation |
T7942 | 12033-12040 | Positive_regulation | denotes | induces |
T7941 | 12045-12056 | Binding | denotes | recruitment |
T7940 | 12212-12219 | Binding | denotes | recruit |
T7939 | 11893-11901 | Positive_regulation | denotes | activate |
T7938 | 11612-11620 | Regulation | denotes | modifies |
T7937 | 11447-11454 | Binding | denotes | recruit |
T7936 | 11313-11327 | Binding | denotes | ubiquitination |
T7935 | 11197-11202 | Binding | denotes | bound |
T7934 | 11219-11227 | Regulation | denotes | modified |
T7933 | 11071-11075 | Binding | denotes | bind |
T7932 | 10799-10810 | Negative_regulation | denotes | stimulation |
T7931 | 10811-10818 | Positive_regulation | denotes | results |
T7930 | 10826-10837 | Binding | denotes | recruitment |
T7929 | 15890-15894 | Protein | denotes | CD40 |
T7928 | 15850-15855 | Protein | denotes | TRAF3 |
T7927 | 15803-15808 | Protein | denotes | TRAF2 |
T7926 | 15780-15784 | Protein | denotes | IL-6 |
T7925 | 15747-15751 | Protein | denotes | CD40 |
T7924 | 15725-15730 | Protein | denotes | TRAF6 |
T7923 | 15676-15680 | Protein | denotes | CD40 |
T7922 | 15499-15504 | Protein | denotes | TRAF3 |
T7921 | 15489-15494 | Protein | denotes | TRAF2 |
T7920 | 15440-15445 | Protein | denotes | TRAF6 |
T7919 | 15429-15434 | Protein | denotes | TRAF5 |
T7918 | 15422-15427 | Protein | denotes | TRAF3 |
T7917 | 15415-15420 | Protein | denotes | TRAF2 |
T7916 | 15408-15413 | Protein | denotes | TRAF1 |
T7915 | 15357-15361 | Protein | denotes | RANK |
T7914 | 15348-15352 | Protein | denotes | CD40 |
T7913 | 15228-15232 | Protein | denotes | RANK |
T7912 | 15201-15223 | Protein | denotes | lymphotoxin β receptor |
T7911 | 15195-15199 | Protein | denotes | CD40 |
T7910 | 13798-13802 | Protein | denotes | IKK1 |
T7909 | 13777-13780 | Protein | denotes | NIK |
T7908 | 13725-13728 | Protein | denotes | NIK |
T7907 | 13672-13677 | Protein | denotes | TRAF3 |
T7906 | 13634-13635 | Protein | denotes | 2 |
T7905 | 13628-13633 | Protein | denotes | cIAP1 |
T7904 | 13618-13623 | Protein | denotes | TRAF2 |
T7903 | 13540-13545 | Protein | denotes | TRAF3 |
T7902 | 13395-13396 | Protein | denotes | 2 |
T7901 | 13389-13394 | Protein | denotes | cIAP1 |
T7900 | 13378-13383 | Protein | denotes | TRAF3 |
T7899 | 13371-13376 | Protein | denotes | TRAF2 |
T7898 | 13330-13333 | Protein | denotes | NIK |
T7897 | 13426-13429 | Protein | denotes | NIK |
T7896 | 13185-13188 | Protein | denotes | NIK |
T7895 | 13179-13182 | Protein | denotes | NIK |
T7894 | 13156-13177 | Protein | denotes | NF-κB inducing kinase |
T7893 | 13107-13111 | Protein | denotes | IKK1 |
T7892 | 12892-12896 | Protein | denotes | RelB |
T7891 | 12863-12866 | Protein | denotes | p52 |
T7890 | 12824-12828 | Protein | denotes | p100 |
T7889 | 12790-12794 | Protein | denotes | RANK |
T7888 | 12780-12784 | Protein | denotes | CD40 |
T7887 | 12765-12778 | Protein | denotes | BAFF receptor |
T7886 | 12741-12763 | Protein | denotes | lymphotoxin β receptor |
T7885 | 12662-12665 | Protein | denotes | TNF |
T7884 | 12597-12601 | Protein | denotes | TAK1 |
T7883 | 12533-12537 | Protein | denotes | RIP1 |
T7882 | 12518-12523 | Protein | denotes | TRAF6 |
T7881 | 12499-12503 | Protein | denotes | TRIF |
T7880 | 12487-12492 | Protein | denotes | TRAF6 |
T7879 | 12427-12432 | Protein | denotes | TRAF6 |
T7878 | 12347-12352 | Protein | denotes | MyD88 |
T7877 | 12326-12330 | Protein | denotes | TRIF |
T7876 | 12281-12324 | Protein | denotes | TIR domain-containing adaptor-inducing IFNβ |
T7875 | 12270-12275 | Protein | denotes | MyD88 |
T7874 | 12220-12268 | Protein | denotes | myeloid differentiation primary response gene 88 |
T7873 | 12156-12160 | Protein | denotes | TRAM |
T7872 | 12125-12154 | Protein | denotes | TRIF-related adaptor molecule |
T7871 | 12116-12118 | Protein | denotes | Ma |
T7870 | 12060-12094 | Protein | denotes | Toll/IL-1 receptor adaptor protein |
T7869 | 11994-11998 | Protein | denotes | TLR4 |
T7868 | 11906-11910 | Protein | denotes | TAK1 |
T7867 | 11680-11683 | Protein | denotes | TNF |
T7866 | 11621-11625 | Protein | denotes | NEMO |
T7865 | 11529-11530 | Protein | denotes | 2 |
T7864 | 11524-11528 | Protein | denotes | TAB1 |
T7863 | 11515-11519 | Protein | denotes | NEMO |
T7862 | 11467-11471 | Protein | denotes | TAK1 |
T7861 | 11405-11409 | Protein | denotes | RIP1 |
T7860 | 11308-11312 | Protein | denotes | RIP1 |
T7859 | 11282-11283 | Protein | denotes | 2 |
T7858 | 11276-11281 | Protein | denotes | cIAP1 |
T7857 | 11270-11271 | Protein | denotes | 5 |
T7856 | 11264-11269 | Protein | denotes | TRAF2 |
T7855 | 11203-11207 | Protein | denotes | RIP1 |
T7854 | 11167-11170 | Protein | denotes | TNF |
T7853 | 11146-11151 | Protein | denotes | cIAP2 |
T7852 | 11101-11141 | Protein | denotes | cellular inhibitor of apoptosis (cIAP) 1 |
T7851 | 11050-11055 | Protein | denotes | TRAF5 |
T7850 | 11006-11045 | Protein | denotes | TNF receptor-associated factor (TRAF) 2 |
T7849 | 10935-10939 | Protein | denotes | RIP1 |
T7848 | 10903-10933 | Protein | denotes | receptor interacting protein 1 |
T7847 | 10881-10886 | Protein | denotes | TRADD |
T7846 | 10841-10879 | Protein | denotes | TNF receptor-1-associated death domain |
T7845 | 10795-10798 | Protein | denotes | TNF |
T7844 | 10782-10785 | Protein | denotes | TNF |
T7843 | 8474-8478 | Protein | denotes | IKK1 |
T7842 | 8460-8464 | Protein | denotes | NEMO |
T7841 | 8451-8455 | Protein | denotes | IKK2 |
T7840 | 8394-8398 | Protein | denotes | IKKγ |
T7839 | 8373-8377 | Protein | denotes | NEMO |
T7838 | 8346-8371 | Protein | denotes | NF-κB essential modulator |
T7837 | 8313-8317 | Protein | denotes | IKKβ |
T7836 | 8304-8308 | Protein | denotes | IKKα |
T7835 | 8284-8288 | Protein | denotes | IKK2 |
T7834 | 8275-8279 | Protein | denotes | IKK1 |
T7833 | 7830-7835 | Protein | denotes | RANKL |
T7832 | 7808-7811 | Protein | denotes | TNF |
T7831 | 7481-7484 | Protein | denotes | p50 |
T7830 | 7473-7476 | Protein | denotes | p52 |
T7829 | 7446-7450 | Protein | denotes | p105 |
T7828 | 7437-7441 | Protein | denotes | p100 |
T7827 | 7374-7379 | Protein | denotes | Bcl-3 |
T7826 | 7365-7369 | Protein | denotes | IκBξ |
T7825 | 7326-7332 | Protein | denotes | NF-κB2 |
T7824 | 7306-7310 | Protein | denotes | p100 |
T7823 | 7297-7303 | Protein | denotes | NF-κB1 |
T7822 | 7277-7281 | Protein | denotes | p105 |
T7821 | 7271-7275 | Protein | denotes | IκBε |
T7820 | 7265-7269 | Protein | denotes | IκBβ |
T7819 | 7259-7263 | Protein | denotes | IκBα |
T3583 | 6570-6577 | Positive_regulation | denotes | induced |
T3582 | 6147-6156 | Positive_regulation | denotes | increased |
T3581 | 6032-6040 | Localization | denotes | released |
T3580 | 5995-6003 | Localization | denotes | secreted |
T3579 | 4765-4775 | Gene_expression | denotes | expression |
T3578 | 4756-4764 | Positive_regulation | denotes | Enhanced |
T3577 | 4207-4214 | Binding | denotes | Binding |
T3576 | 4264-4273 | Gene_expression | denotes | expressed |
T3575 | 3967-3976 | Gene_expression | denotes | expressed |
T3574 | 4146-4157 | Positive_regulation | denotes | upregulated |
T3573 | 6759-6769 | Protein | denotes | tenascin C |
T3572 | 6749-6757 | Protein | denotes | biglycan |
T3571 | 6736-6747 | Protein | denotes | fibronectin |
T3570 | 6565-6569 | Protein | denotes | TLR4 |
T3569 | 6341-6367 | Protein | denotes | myeloid-related protein 14 |
T3568 | 6311-6336 | Protein | denotes | Myeloid-related protein 8 |
T3567 | 6248-6253 | Protein | denotes | HMGB1 |
T3566 | 6183-6188 | Protein | denotes | HMGB1 |
T3565 | 6138-6143 | Protein | denotes | HMGB1 |
T3564 | 6099-6111 | Protein | denotes | TLR4 ligands |
T3563 | 5954-5973 | Protein | denotes | chromatin component |
T3562 | 5927-5932 | Protein | denotes | HMGB1 |
T3561 | 5880-5925 | Protein | denotes | High mobility group box chromosomal protein 1 |
T3560 | 5011-5033 | Protein | denotes | lymphotoxin β receptor |
T3559 | 4957-4961 | Protein | denotes | BAFF |
T3558 | 4836-4840 | Protein | denotes | BAFF |
T3557 | 4810-4834 | Protein | denotes | B-cell activating factor |
T3556 | 4576-4580 | Protein | denotes | CD40 |
T3555 | 4302-4305 | Protein | denotes | CD4 |
T3554 | 4235-4240 | Protein | denotes | CD154 |
T3553 | 4222-4233 | Protein | denotes | CD40 ligand |
T3552 | 4197-4200 | Protein | denotes | TNF |
T3551 | 3919-3945 | Protein | denotes | TNF receptor family member |
T3550 | 3903-3907 | Protein | denotes | CD40 |
T3549 | 3789-3793 | Protein | denotes | RANK |
T3548 | 3693-3697 | Protein | denotes | RANK |
T3547 | 3664-3691 | Protein | denotes | receptor activator of NF-κB |
T3546 | 3450-3453 | Protein | denotes | TNF |
T3545 | 3375-3378 | Protein | denotes | TNF |
T3544 | 3316-3319 | Protein | denotes | TNF |
T1527 | 2869-2880 | Binding | denotes | association |
T1526 | 1836-1846 | Gene_expression | denotes | expression |
T1525 | 1823-1831 | Regulation | denotes | regulate |
T1524 | 2966-2971 | Protein | denotes | c-REL |
T1523 | 2953-2960 | Protein | denotes | TNFAIP3 |
T1522 | 2946-2951 | Protein | denotes | TRAF1 |
T1521 | 2940-2944 | Protein | denotes | CD40 |
T1520 | 2690-2695 | Protein | denotes | RANKL |
T1519 | 2654-2688 | Protein | denotes | receptor activator of NF-κB ligand |
T1518 | 2035-2038 | Protein | denotes | TNF |
T1517 | 1884-1887 | Protein | denotes | TNF |
T1516 | 1758-1763 | Protein | denotes | c-Rel |
T1515 | 1752-1756 | Protein | denotes | RelB |
T1514 | 1746-1750 | Protein | denotes | RelA |
T1513 | 1739-1742 | Protein | denotes | p65 |
T1512 | 1731-1737 | Protein | denotes | NF-κB1 |
T1511 | 1723-1727 | Protein | denotes | p105 |
T1510 | 1715-1721 | Protein | denotes | NF-κB2 |
T1509 | 1932-1963 | Protein | denotes | inducible nitric oxide synthase |
T1508 | 1901-1918 | Protein | denotes | cyclo-oxygenase-2 |
T1507 | 1895-1899 | Protein | denotes | IL-6 |
T1506 | 1707-1711 | Protein | denotes | p100 |
T21009 | 8656-8660 | Protein | denotes | CD40 |
T21008 | 8926-8931 | Protein | denotes | cIAP2 |
T21007 | 8919-8924 | Protein | denotes | cIAP1 |
T21006 | 8912-8917 | Protein | denotes | TRAF6 |
T21005 | 8905-8910 | Protein | denotes | TRAF2 |
T21004 | 8874-8879 | Protein | denotes | IRAK4 |
T21003 | 8867-8872 | Protein | denotes | IRAK1 |
T21002 | 8861-8865 | Protein | denotes | RIP1 |
T21001 | 8844-8848 | Protein | denotes | TRIF |
T21000 | 8649-8654 | Protein | denotes | TNFR1 |
T21010 | 8662-8666 | Protein | denotes | RANK |
T18785 | 32702-32712 | Gene_expression | denotes | expression |
T18784 | 32521-32530 | Positive_regulation | denotes | increased |
T18783 | 32531-32540 | Localization | denotes | secretion |
T18782 | 32481-32489 | Positive_regulation | denotes | elevated |
T18781 | 32421-32430 | Negative_regulation | denotes | decreased |
T18780 | 31684-31694 | Gene_expression | denotes | production |
T18779 | 31672-31679 | Positive_regulation | denotes | promote |
T18778 | 31458-31472 | Positive_regulation | denotes | overexpression |
T18777 | 31458-31472 | Gene_expression | denotes | overexpression |
T18776 | 31269-31278 | Gene_expression | denotes | producing |
T18775 | 31237-31250 | Positive_regulation | denotes | overexpressed |
T21028 | 9534-9537 | Protein | denotes | A20 |
T21027 | 9400-9405 | Protein | denotes | TRAF1 |
T21026 | 9329-9332 | Protein | denotes | p50 |
T21025 | 9321-9324 | Protein | denotes | p65 |
T21024 | 9195-9199 | Protein | denotes | IκBα |
T21023 | 9160-9164 | Protein | denotes | IKK2 |
T21022 | 9121-9125 | Protein | denotes | TAK1 |
T21021 | 9115-9119 | Protein | denotes | TAK1 |
T21020 | 9106-9110 | Protein | denotes | IKK2 |
T21019 | 9023-9027 | Protein | denotes | NEMO |
T21018 | 8999-9004 | Protein | denotes | IRAK1 |
T21017 | 8990-8994 | Protein | denotes | RIP1 |
T21016 | 8799-8842 | Protein | denotes | TIR domain-containing adaptor-inducing IFNβ |
T21015 | 8794-8797 | Protein | denotes | MAL |
T21014 | 8787-8792 | Protein | denotes | MyD88 |
T21013 | 8779-8784 | Protein | denotes | TRADD |
T21012 | 8731-8777 | Protein | denotes | TNF receptor 1-associated death domain protein |
T21011 | 8672-8676 | Protein | denotes | TLR4 |
R1206 | T1507 | T1526 | themeOf | IL-6,expression |
R1254 | T1508 | T1526 | themeOf | cyclo-oxygenase-2,expression |
R1255 | T1509 | T1526 | themeOf | inducible nitric oxide synthase,expression |
R1256 | T1517 | T1526 | themeOf | TNF,expression |
R1257 | T1523 | T1527 | themeOf | TNFAIP3,association |
R1259 | T1526 | T1525 | themeOf | expression,regulate |
R1260 | T1526 | T1525 | themeOf | expression,regulate |
R1261 | T1526 | T1525 | themeOf | expression,regulate |
R1262 | T1526 | T1525 | themeOf | expression,regulate |
R2748 | T3550 | T3574 | themeOf | CD40,upregulated |
R2749 | T3550 | T3575 | themeOf | CD40,expressed |
R2751 | T3551 | T3574 | themeOf | TNF receptor family member,upregulated |
R2752 | T3551 | T3575 | themeOf | TNF receptor family member,expressed |
R2753 | T3552 | T3574 | causeOf | TNF,upregulated |
R2754 | T3552 | T3574 | causeOf | TNF,upregulated |
R2755 | T3553 | T3576 | themeOf | CD40 ligand,expressed |
R2756 | T3553 | T3577 | themeOf | CD40 ligand,Binding |
R2757 | T3554 | T3576 | themeOf | CD154,expressed |
R2758 | T3554 | T3577 | themeOf | CD154,Binding |
R2759 | T3557 | T3579 | themeOf | B-cell activating factor,expression |
R2760 | T3558 | T3579 | themeOf | BAFF,expression |
R2761 | T3561 | T3580 | themeOf | High mobility group box chromosomal protein 1,secreted |
R2762 | T3561 | T3581 | themeOf | High mobility group box chromosomal protein 1,released |
R2763 | T3562 | T3581 | themeOf | HMGB1,released |
R2764 | T3563 | T3580 | themeOf | chromatin component,secreted |
R2765 | T3563 | T3581 | themeOf | chromatin component,released |
R2766 | T3564 | T3581 | themeOf | TLR4 ligands,released |
R2767 | T3565 | T3582 | themeOf | HMGB1,increased |
R2769 | T3570 | T3583 | themeOf | TLR4,induced |
R2770 | T3579 | T3578 | themeOf | expression,Enhanced |
R2771 | T3579 | T3578 | themeOf | expression,Enhanced |
R5432 | T7855 | T7935 | themeOf | RIP1,bound |
R5433 | T7855 | T7934 | themeOf | RIP1,modified |
R5435 | T7845 | T7932 | themeOf | TNF,stimulation |
R5437 | T7846 | T7930 | themeOf | TNF receptor-1-associated death domain,recruitment |
R5438 | T7847 | T7930 | themeOf | TRADD,recruitment |
R5439 | T7848 | T7930 | themeOf | receptor interacting protein 1,recruitment |
R5441 | T7849 | T7930 | themeOf | RIP1,recruitment |
R5443 | T7851 | T7933 | themeOf | TRAF5,bind |
R5444 | T7851 | T7933 | themeOf | TRAF5,bind |
R5446 | T7852 | T7933 | themeOf | cellular inhibitor of apoptosis (cIAP) 1,bind |
R5447 | T7853 | T7933 | themeOf | cIAP2,bind |
R5492 | T7906 | T7954 | themeOf | 2,attract |
R5494 | T7907 | T7955 | themeOf | TRAF3,degradation |
R5496 | T7908 | T7960 | themeOf | NIK,degradation |
R5535 | T7924 | T7966 | causeOf | TRAF6,required |
R5536 | T7926 | T7967 | themeOf | IL-6,production |
R5537 | T7927 | T7965 | themeOf | TRAF2,required |
R5538 | T7930 | T7931 | themeOf | recruitment,results |
R5540 | T7930 | T7931 | themeOf | recruitment,results |
R5541 | T7930 | T7931 | themeOf | recruitment,results |
R5542 | T7930 | T7931 | themeOf | recruitment,results |
R5543 | T7941 | T7942 | themeOf | recruitment,induces |
R5546 | T7941 | T7942 | themeOf | recruitment,induces |
R5547 | T7941 | T7942 | themeOf | recruitment,induces |
R5548 | T7950 | T7951 | themeOf | degradation,leading |
R6305 | T9273 | T9282 | themeOf | IKK1,deficient |
R6306 | T9274 | T9284 | themeOf | IKK1,expressing |
R6307 | T9275 | T9283 | themeOf | IKK2,activation |
R6308 | T9276 | T9286 | themeOf | IκBα,degradation |
R6309 | T9277 | T9288 | themeOf | STAT1,phosphorylating |
R6310 | T9280 | T9289 | themeOf | NIK,phosphorylates |
R6311 | T9283 | T9287 | themeOf | activation,enhanced |
R6312 | T9284 | T9282 | themeOf | expressing,deficient |
R6313 | T9286 | T9285 | themeOf | degradation,result |
R8223 | T12182 | T12243 | themeOf | A20,regulates |
R8225 | T12257 | T12258 | themeOf | expression,regulated |
R8226 | T12191 | T12244 | themeOf | RIP2,interactions |
R8227 | T12192 | T12246 | themeOf | Ubc13,disruption |
R8228 | T12192 | T12245 | themeOf | Ubc13,interactions |
R8229 | T12193 | T12245 | themeOf | Ubc5hc,interactions |
R8230 | T12194 | T12245 | themeOf | TRAF6,interactions |
R8231 | T12195 | T12245 | themeOf | TRAF2,interactions |
R8232 | T12196 | T12245 | themeOf | cIAP1,interactions |
R8233 | T12197 | T12245 | themeOf | 2,interactions |
R8234 | T12266 | T12267 | themeOf | overexpression,overexpression |
R8235 | T12199 | T12247 | themeOf | A20,association |
R8236 | T12200 | T12249 | themeOf | A20-binding inhibitor of NF-κB (ABIN) 1,requires |
R8237 | T12202 | T12250 | themeOf | A20,inhibitor |
R8238 | T12203 | T12251 | themeOf | A20,regulates |
R8239 | T12204 | T12252 | themeOf | A20,deficient |
R8240 | T12205 | T12253 | themeOf | A20,deficient |
R8241 | T12207 | T12254 | themeOf | A20,lacking |
R8242 | T12210 | T12255 | themeOf | A20,lacking |
R8243 | T12274 | T12275 | themeOf | transcription,repressed |
R8244 | T12211 | T12256 | themeOf | A20,expression |
R8245 | T12212 | T12257 | themeOf | A20,expression |
R8246 | T12214 | T12259 | themeOf | A20,expressing |
R8247 | T12215 | T12263 | themeOf | A20,expression |
R8248 | T12216 | T12261 | themeOf | TNF,inhibition |
R8249 | T12216 | T12260 | themeOf | TNF,decreased |
R8250 | T12217 | T12261 | themeOf | IL-1β,inhibition |
R8251 | T12217 | T12260 | themeOf | IL-1β,decreased |
R8252 | T12218 | T12261 | themeOf | IL-6,inhibition |
R8253 | T12218 | T12260 | themeOf | IL-6,decreased |
R8254 | T12219 | T12260 | themeOf | RANKL,decreased |
R8255 | T12220 | T12261 | themeOf | monocyte chemo-attractant protein 1,inhibition |
R8256 | T12220 | T12260 | themeOf | monocyte chemo-attractant protein 1,decreased |
R8257 | T12221 | T12262 | themeOf | A20,expression |
R8258 | T12224 | T12264 | themeOf | TNF,decreased |
R8259 | T12225 | T12264 | themeOf | IL-1β,decreased |
R8260 | T12226 | T12265 | themeOf | A20,transduced |
R8262 | T12227 | T12266 | themeOf | A20,overexpression |
R8263 | T12229 | T12268 | themeOf | A20,lack |
R8264 | T12231 | T12269 | themeOf | A20,association |
R8265 | T12232 | T12270 | themeOf | A20,influence |
R8266 | T12234 | T12271 | themeOf | A20,required |
R8267 | T12235 | T12272 | themeOf | TNF,induced |
R8268 | T12239 | T12273 | themeOf | A20,affect |
R8269 | T12241 | T12274 | themeOf | A20,transcription |
R8272 | T12247 | T12248 | themeOf | association,targets |
R9260 | T13843 | T13874 | themeOf | A20,binding |
R9261 | T13845 | T13875 | themeOf | ABIN-2,expressed |
R9262 | T13846 | T13875 | themeOf | ABIN-3,expressed |
R9263 | T13847 | T13875 | themeOf | TNIP-1,expressed |
R9264 | T13848 | T13875 | themeOf | TNIP-2,expressed |
R9265 | T13850 | T13875 | themeOf | A20,expressed |
R9266 | T13850 | T13876 | themeOf | A20,interacting |
R9267 | T13852 | T13877 | themeOf | A20,target |
R9268 | T13854 | T13879 | themeOf | ABIN-1,expression |
R9269 | T13855 | T13879 | themeOf | ABIN-3,expression |
R9270 | T13856 | T13878 | themeOf | A20,role |
R9271 | T13857 | T13881 | themeOf | ABIN-1,deficient |
R9272 | T13857 | T13880 | themeOf | ABIN-1,deficient |
R9273 | T13858 | T13880 | themeOf | ABIN-2,deficient |
R9274 | T13859 | T13882 | themeOf | ABIN-3,expressed |
R9275 | T13860 | T13883 | themeOf | truncated and inactive form,express |
R9276 | T13864 | T13884 | themeOf | ABIN-1,deficient |
R9277 | T13867 | T13886 | themeOf | TNF,induced |
R9278 | T13868 | T13885 | themeOf | ABIN-1,levels |
R9280 | T13872 | T13887 | themeOf | A20,expression |
R9281 | T13887 | T13888 | themeOf | expression,depend |
R9282 | T13887 | T13888 | themeOf | expression,depend |
R10719 | T16176 | T16192 | themeOf | Single-immunoglobulin IL-1 receptor-related,inhibitor |
R10720 | T16176 | T16193 | themeOf | Single-immunoglobulin IL-1 receptor-related,interaction |
R10721 | T16177 | T16192 | themeOf | SIGIRR,inhibitor |
R10722 | T16177 | T16193 | themeOf | SIGIRR,interaction |
R10723 | T16178 | T16192 | themeOf | TIR-8,inhibitor |
R10724 | T16178 | T16193 | themeOf | TIR-8,interaction |
R10725 | T16179 | T16192 | themeOf | IL-1R,inhibitor |
R10726 | T16181 | T16192 | themeOf | IRAK1,inhibitor |
R10727 | T16181 | T16193 | themeOf | IRAK1,interaction |
R10728 | T16185 | T16194 | themeOf | SIGIRR,expressed |
R10729 | T16186 | T16195 | themeOf | SIGIRR,overexpression |
R10730 | T16188 | T16197 | themeOf | SIGIRR,deficient |
R10731 | T16189 | T16198 | themeOf | SIGIRR,expression |
R10732 | T16191 | T16199 | themeOf | SIGIRR,target |
R10733 | T16191 | T16200 | themeOf | SIGIRR,expression |
R10734 | T16195 | T16196 | themeOf | overexpression,overexpression |
R11350 | T17189 | T17207 | themeOf | TRAF1,Expression |
R11351 | T17190 | T17209 | causeOf | TNF,inducible |
R11352 | T17191 | T17208 | themeOf | TRAF1,overexpression |
R11353 | T17194 | T17210 | themeOf | TRAF1,deficient |
R11354 | T17197 | T17211 | themeOf | TRAF1,deficient |
R11355 | T17200 | T17212 | themeOf | TRAF1,binding |
R11356 | T17201 | T17214 | themeOf | TRAF1,recruit |
R11357 | T17202 | T17213 | themeOf | A20,interact |
R11358 | T17202 | T17214 | themeOf | A20,recruit |
R11359 | T17205 | T17215 | themeOf | TRAF1,association |
R11360 | T17207 | T17209 | themeOf | Expression,inducible |
R11361 | T17208 | T17206 | themeOf | overexpression,overexpression |
R12435 | T18747 | T18772 | themeOf | miR-146a,NF-κB-dependent |
R12436 | T18754 | T18773 | themeOf | miR-155,expressed |
R12437 | T18755 | T18774 | themeOf | miR-146a,overexpressed |
R12438 | T18757 | T18776 | themeOf | IL-17,producing |
R12439 | T18759 | T18777 | themeOf | miR-155,overexpression |
R12440 | T18761 | T18780 | themeOf | TNF,production |
R12441 | T18764 | T18781 | themeOf | miR-124a,decreased |
R12442 | T18766 | T18782 | themeOf | miR-203,elevated |
R12443 | T18767 | T18783 | themeOf | matrix metalloproteinase-1,secretion |
R12444 | T18768 | T18783 | themeOf | IL-6,secretion |
R12445 | T18770 | T18785 | themeOf | miR-132,expression |
R12446 | T18774 | T18775 | themeOf | overexpressed,overexpressed |
R12447 | T18777 | T18778 | themeOf | overexpression,overexpression |
R12448 | T18780 | T18779 | themeOf | production,promote |
R12449 | T18783 | T18784 | themeOf | secretion,increased |
R12450 | T18783 | T18784 | themeOf | secretion,increased |
R13828 | T21000 | T21058 | themeOf | TNFR1,engagement |
R13829 | T21001 | T21056 | themeOf | TRIF,recruitment |
R13830 | T21002 | T21056 | themeOf | RIP1,recruitment |
R13831 | T21003 | T21056 | themeOf | IRAK1,recruitment |
R13832 | T21004 | T21056 | themeOf | IRAK4,recruitment |
R13833 | T21005 | T21056 | themeOf | TRAF2,recruitment |
R13834 | T21006 | T21056 | themeOf | TRAF6,recruitment |
R13835 | T21007 | T21056 | themeOf | cIAP1,recruitment |
R13836 | T21008 | T21056 | themeOf | cIAP2,recruitment |
R13837 | T21009 | T21058 | themeOf | CD40,engagement |
R13838 | T21010 | T21058 | themeOf | RANK,engagement |
R13839 | T21011 | T21058 | themeOf | TLR4,engagement |
R13840 | T21012 | T21056 | themeOf | TNF receptor 1-associated death domain protein,recruitment |
R13841 | T21013 | T21056 | themeOf | TRADD,recruitment |
R13842 | T21014 | T21056 | themeOf | MyD88,recruitment |
R13843 | T21015 | T21056 | themeOf | MAL,recruitment |
R13844 | T21016 | T21056 | themeOf | TIR domain-containing adaptor-inducing IFNβ,recruitment |
R13845 | T21017 | T21061 | themeOf | RIP1,polyubiquitination |
R13846 | T21018 | T21061 | themeOf | IRAK1,polyubiquitination |
R13847 | T21020 | T21059 | themeOf | IKK2,recruitment |
R13848 | T21021 | T21059 | themeOf | TAK1,recruitment |
R13849 | T21021 | T21060 | themeOf | TAK1,activation |
R13850 | T21022 | T21063 | themeOf | TAK1,phosphorylates |
R13851 | T21022 | T21062 | causeOf | TAK1,activates |
R13852 | T21023 | T21063 | themeOf | IKK2,phosphorylates |
R13853 | T21023 | T21062 | themeOf | IKK2,activates |
R13854 | T21024 | T21064 | themeOf | IκBα,phosphorylates |
R13855 | T21025 | T21065 | themeOf | p65,heterodimer |
R13856 | T21026 | T21065 | themeOf | p50,heterodimer |
R13857 | T21028 | T21066 | themeOf | A20,targeting |
R13858 | T21028 | T21066 | themeOf | A20,targeting |
R13859 | T21030 | T21066 | themeOf | RIP1,targeting |
R13860 | T21031 | T21066 | themeOf | TRAF6,targeting |
R13861 | T21034 | T21067 | themeOf | IRAK1,expression |
R13862 | T21035 | T21067 | themeOf | TRAF6,expression |
R13863 | T21037 | T21069 | themeOf | TLR4,compete |
R13864 | T21037 | T21070 | themeOf | TLR4,binding |
R13865 | T21037 | T21070 | themeOf | TLR4,binding |
R13866 | T21038 | T21070 | themeOf | IRAK1,binding |
R13867 | T21039 | T21070 | themeOf | TRAF6,binding |
R13868 | T21056 | T21057 | themeOf | recruitment,trigger |
R13869 | T21056 | T21057 | themeOf | recruitment,trigger |
R13870 | T21056 | T21057 | themeOf | recruitment,trigger |
R13871 | T21056 | T21057 | themeOf | recruitment,trigger |
R13872 | T21056 | T21057 | themeOf | recruitment,trigger |
R13873 | T21056 | T21057 | themeOf | recruitment,trigger |
R13874 | T21056 | T21057 | themeOf | recruitment,trigger |
R13875 | T21056 | T21057 | themeOf | recruitment,trigger |
R13876 | T21056 | T21057 | themeOf | recruitment,trigger |
R13880 | T21056 | T21057 | themeOf | recruitment,trigger |
R13881 | T21067 | T21068 | themeOf | expression,inhibiting |
R13882 | T21067 | T21068 | themeOf | expression,inhibiting |
R14569 | T22369 | T22402 | themeOf | NF-κB inducing kinase,dependent |
R14570 | T22369 | T22401 | themeOf | NF-κB inducing kinase,expression |
R14571 | T22370 | T22401 | themeOf | NIK,expression |
R14572 | T22371 | T22405 | themeOf | NIK,polyubiquitination |
R14573 | T22371 | T22404 | themeOf | NIK,degradation |
R14575 | T22380 | T22406 | themeOf | cIAP1,polyubiquitination |
R14591 | T22404 | T22403 | themeOf | degradation,facilitates |
R14592 | T22405 | T22403 | themeOf | polyubiquitination,facilitates |
R5434 | T7860 | T7936 | themeOf | RIP1,ubiquitination |
R5436 | T7862 | T7937 | themeOf | TAK1,recruit |
R5440 | T7862 | T7937 | themeOf | TAK1,recruit |
R5442 | T7862 | T7937 | themeOf | TAK1,recruit |
R5445 | T7863 | T7937 | themeOf | NEMO,recruit |
R5448 | T7864 | T7937 | themeOf | TAB1,recruit |
R5449 | T7865 | T7937 | themeOf | 2,recruit |
R5450 | T7955 | T7957 | themeOf | degradation,essential |
R5451 | T7866 | T7938 | themeOf | NEMO,modifies |
R5452 | T7958 | T7959 | themeOf | accumulation,resulting |
R5453 | T7868 | T7939 | themeOf | TAK1,activate |
R5454 | T7962 | T7959 | themeOf | phosphorylation,resulting |
R5455 | T7869 | T7943 | themeOf | TLR4,stimulation |
R5456 | T7870 | T7941 | themeOf | Toll/IL-1 receptor adaptor protein,recruitment |
R5457 | T7872 | T7941 | themeOf | TRIF-related adaptor molecule,recruitment |
R5459 | T7873 | T7941 | themeOf | TRAM,recruitment |
R5460 | T7874 | T7940 | themeOf | myeloid differentiation primary response gene 88,recruit |
R5461 | T7875 | T7940 | themeOf | MyD88,recruit |
R5462 | T7876 | T7940 | themeOf | TIR domain-containing adaptor-inducing IFNβ,recruit |
R5463 | T7877 | T7940 | themeOf | TRIF,recruit |
R5464 | T7881 | T7945 | themeOf | TRIF,interaction |
R5465 | T7882 | T7944 | themeOf | TRAF6,recruits |
R5466 | T7883 | T7944 | themeOf | RIP1,recruits |
R5469 | T7884 | T7946 | themeOf | TAK1,activate |
R5470 | T7892 | T7947 | themeOf | RelB,regulates |
R5476 | T7893 | T7948 | themeOf | IKK1,activated |
R5477 | T7893 | T7948 | themeOf | IKK1,activated |
R5478 | T7894 | T7948 | causeOf | NF-κB inducing kinase,activated |
R5480 | T7895 | T7948 | causeOf | NIK,activated |
R5481 | T7896 | T7949 | themeOf | NIK,regulated |
R5482 | T7897 | T7952 | themeOf | NIK,K48-polyubiquitinates |
R5483 | T7897 | T7950 | themeOf | NIK,degradation |
R5484 | T7901 | T7953 | themeOf | cIAP1,complex |
R5485 | T7903 | T7956 | themeOf | TRAF3,remove |
R5486 | T7904 | T7954 | themeOf | TRAF2,attract |
R5488 | T7905 | T7954 | themeOf | cIAP1,attract |
R5490 | T7905 | T7957 | themeOf | cIAP1,essential |
R5458 | T7967 | T7966 | themeOf | production,required |
R5498 | T7908 | T7961 | themeOf | NIK,releasing |
R5499 | T7909 | T7958 | themeOf | NIK,accumulation |
R5503 | T7910 | T7962 | themeOf | IKK1,phosphorylation |
R5504 | T7914 | T7964 | themeOf | CD40,interact |
R5507 | T7914 | T7964 | themeOf | CD40,interact |
R5509 | T7914 | T7964 | themeOf | CD40,interact |
R5510 | T7914 | T7964 | themeOf | CD40,interact |
R5512 | T7914 | T7964 | themeOf | CD40,interact |
R5513 | T7915 | T7964 | themeOf | RANK,interact |
R5515 | T7915 | T7964 | themeOf | RANK,interact |
R5516 | T7915 | T7964 | themeOf | RANK,interact |
R5517 | T7915 | T7964 | themeOf | RANK,interact |
R5518 | T7915 | T7964 | themeOf | RANK,interact |
R5519 | T7916 | T7964 | themeOf | TRAF1,interact |
R5520 | T7916 | T7964 | themeOf | TRAF1,interact |
R5521 | T7917 | T7964 | themeOf | TRAF2,interact |
R5523 | T7917 | T7964 | themeOf | TRAF2,interact |
R5524 | T7918 | T7964 | themeOf | TRAF3,interact |
R5525 | T7918 | T7964 | themeOf | TRAF3,interact |
R5526 | T7919 | T7964 | themeOf | TRAF5,interact |
R5528 | T7919 | T7964 | themeOf | TRAF5,interact |
R5529 | T7920 | T7964 | themeOf | TRAF6,interact |
R5531 | T7920 | T7964 | themeOf | TRAF6,interact |
R5533 | T7921 | T7963 | themeOf | TRAF2,proteolysis |
R5534 | T7922 | T7963 | themeOf | TRAF3,proteolysis |
R9279 | T13871 | T13887 | themeOf | ABIN-3,expression |
R10133 | T15273 | T15294 | themeOf | A20,targeted |
R10134 | T15276 | T15295 | themeOf | A20,expressed |
R10135 | T15280 | T15296 | themeOf | CYLD,deficiency |
R10136 | T15282 | T15300 | themeOf | CYLD,expression |
R10137 | T15285 | T15299 | themeOf | ubiquitin,binding |
R10138 | T15286 | T15299 | themeOf | p62,binding |
R10139 | T15286 | T15300 | themeOf | p62,expression |
R10140 | T15289 | T15298 | themeOf | TRAF6,deubiquitination |
R10141 | T15290 | T15301 | themeOf | p62,expressing |
R10142 | T15300 | T15297 | themeOf | expression,upregulated |
R10143 | T15300 | T15297 | themeOf | expression,upregulated |
R13877 | T21056 | T21057 | themeOf | recruitment,trigger |
R13878 | T21056 | T21057 | themeOf | recruitment,trigger |
R13879 | T21056 | T21057 | themeOf | recruitment,trigger |
R14574 | T22378 | T22407 | themeOf | TRAF3,recruited |
R14576 | T22381 | T22406 | themeOf | 2,polyubiquitination |
R14577 | T22382 | T22408 | themeOf | cIAP1,polyubiquitination |
R14578 | T22384 | T22408 | themeOf | TRAF3,polyubiquitination |
R14579 | T22385 | T22408 | themeOf | NIK,polyubiquitination |
R14580 | T22386 | T22411 | themeOf | TRAF3,degraded |
R14581 | T22387 | T22409 | themeOf | NIK,stabilised |
R14582 | T22388 | T22413 | themeOf | NIK,resulting |
R14583 | T22388 | T22410 | themeOf | NIK,increased |
R14584 | T22389 | T22415 | themeOf | NIK,phosphorylates |
R14585 | T22389 | T22416 | causeOf | NIK,activates |
R14586 | T22390 | T22415 | themeOf | IKK1,phosphorylates |
R14587 | T22390 | T22416 | themeOf | IKK1,activates |
R14588 | T22391 | T22417 | themeOf | p100,phosphorylation |
R14589 | T22392 | T22418 | themeOf | p100,degradation |
R14590 | T22393 | T22418 | themeOf | p52,degradation |
R14593 | T22411 | T22412 | themeOf | degraded,result |
R14594 | T22417 | T22414 | themeOf | phosphorylation,mediates |
BioNLP16_Messiy
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T22109 | 13959-13980 | Protein | denotes | NF-κB inducing kinase |
T22108 | 13889-13893 | Protein | denotes | RANK |
T22107 | 13880-13884 | Protein | denotes | CD40 |
T22155 | 14740-14751 | Protein_catabolism | denotes | degradation |
T22154 | 14607-14616 | Positive_regulation | denotes | activates |
T22153 | 14588-14602 | Phosphorylation | denotes | phosphorylates |
T22152 | 14649-14664 | Phosphorylation | denotes | phosphorylation |
T22151 | 14629-14637 | Positive_regulation | denotes | mediates |
T22150 | 14545-14554 | Positive_regulation | denotes | increased |
T22149 | 14500-14508 | Protein_catabolism | denotes | degraded |
T22147 | 14326-14344 | Binding | denotes | polyubiquitination |
T22146 | 14376-14386 | Positive_regulation | denotes | activation |
T22145 | 14253-14262 | Binding | denotes | recruited |
T22144 | 14179-14190 | Protein_catabolism | denotes | degradation |
T22143 | 14144-14162 | Binding | denotes | polyubiquitination |
T22142 | 13987-13997 | Gene_expression | denotes | expression |
T22141 | 13946-13955 | Regulation | denotes | dependent |
T22140 | 15143-15165 | Protein | denotes | tumour necrosis factor |
T22139 | 15138-15141 | Protein | denotes | TNF |
T22138 | 15071-15098 | Protein | denotes | receptor activator of NF-κB |
T22137 | 15065-15069 | Protein | denotes | RANK |
T22136 | 14846-14851 | Protein | denotes | TRAF1 |
T22135 | 14839-14844 | Protein | denotes | TRAF3 |
T22134 | 14799-14803 | Protein | denotes | RelB |
T22133 | 14763-14766 | Protein | denotes | p52 |
T22132 | 14755-14759 | Protein | denotes | p100 |
T22131 | 14644-14648 | Protein | denotes | p100 |
T22130 | 14617-14621 | Protein | denotes | IKK1 |
T22129 | 14579-14582 | Protein | denotes | NIK |
T22128 | 14555-14558 | Protein | denotes | NIK |
T22127 | 14513-14516 | Protein | denotes | NIK |
T22126 | 14491-14496 | Protein | denotes | TRAF3 |
T22125 | 14473-14476 | Protein | denotes | NIK |
T22124 | 14454-14459 | Protein | denotes | TRAF3 |
T22123 | 14407-14408 | Protein | denotes | 2 |
T22122 | 14401-14406 | Protein | denotes | cIAP1 |
T22121 | 14354-14355 | Protein | denotes | 2 |
T22120 | 14348-14353 | Protein | denotes | cIAP1 |
T22119 | 14286-14291 | Protein | denotes | TRAF2 |
T22118 | 14244-14249 | Protein | denotes | TRAF3 |
T22117 | 14108-14109 | Protein | denotes | 2 |
T22116 | 14102-14107 | Protein | denotes | cIAP1 |
T22115 | 14092-14097 | Protein | denotes | TRAF3 |
T22114 | 14085-14090 | Protein | denotes | TRAF2 |
T22113 | 14028-14031 | Protein | denotes | NIK |
T22112 | 14207-14210 | Protein | denotes | NIK |
T22111 | 14194-14197 | Protein | denotes | NIK |
T22110 | 13982-13985 | Protein | denotes | NIK |
T20659 | 9914-9923 | Negative_regulation | denotes | inhibited |
T20658 | 10010-10017 | Binding | denotes | binding |
T20649 | 8961-8979 | Positive_regulation | denotes | polyubiquitination |
T20648 | 9046-9055 | Positive_regulation | denotes | resulting |
T20647 | 8599-8609 | Binding | denotes | engagement |
T20646 | 8689-8700 | Binding | denotes | recruitment |
T20645 | 10701-10723 | Protein | denotes | tumour necrosis factor |
T20644 | 10696-10699 | Protein | denotes | TNF |
T20643 | 10558-10600 | Protein | denotes | single-immunoglobulinIL-1 receptor-related |
T20642 | 10550-10556 | Protein | denotes | SIGIRR |
T20641 | 10518-10548 | Protein | denotes | receptor interacting protein 1 |
T20640 | 10512-10516 | Protein | denotes | RIP1 |
T20639 | 10483-10510 | Protein | denotes | receptor activator of NF-κB |
T20638 | 10477-10481 | Protein | denotes | RANK |
T20637 | 10430-10455 | Protein | denotes | NF-κB essential modulator |
T20636 | 10424-10428 | Protein | denotes | NEMO |
T20635 | 10374-10422 | Protein | denotes | myeloid differentiation primary response gene 88 |
T20634 | 10367-10372 | Protein | denotes | MyD88 |
T20633 | 10277-10292 | Protein | denotes | cylindromatosis |
T20632 | 10271-10275 | Protein | denotes | CYLD |
T20631 | 10200-10230 | Protein | denotes | A20-binding inhibitor of NF-κB |
T20630 | 10194-10198 | Protein | denotes | ABIN |
T20629 | 10031-10036 | Protein | denotes | TRAF6 |
T20628 | 10021-10026 | Protein | denotes | IRAK1 |
T20627 | 10001-10005 | Protein | denotes | TLR4 |
T20626 | 9953-9959 | Protein | denotes | SIGIRR |
T20625 | 9871-9876 | Protein | denotes | TRAF6 |
T20624 | 9861-9866 | Protein | denotes | IRAK1 |
T20623 | 9771-9774 | Protein | denotes | p62 |
T20622 | 9760-9766 | Protein | denotes | ABIN-1 |
T20621 | 9667-9672 | Protein | denotes | TRAF6 |
T20620 | 9658-9662 | Protein | denotes | RIP1 |
T20619 | 9542-9546 | Protein | denotes | CYLD |
T20618 | 9534-9537 | Protein | denotes | A20 |
T20617 | 9400-9405 | Protein | denotes | TRAF1 |
T20616 | 9329-9332 | Protein | denotes | p50 |
T20615 | 9321-9324 | Protein | denotes | p65 |
T20614 | 9195-9199 | Protein | denotes | IκBα |
T20613 | 9160-9164 | Protein | denotes | IKK2 |
T20612 | 9121-9125 | Protein | denotes | TAK1 |
T20611 | 9115-9119 | Protein | denotes | TAK1 |
T20610 | 9106-9110 | Protein | denotes | IKK2 |
T20609 | 9023-9027 | Protein | denotes | NEMO |
T20608 | 8999-9004 | Protein | denotes | IRAK1 |
T20607 | 8990-8994 | Protein | denotes | RIP1 |
T20606 | 8799-8842 | Protein | denotes | TIR domain-containing adaptor-inducing IFNβ |
T20605 | 8794-8797 | Protein | denotes | MAL |
T20604 | 8787-8792 | Protein | denotes | MyD88 |
T20603 | 8779-8784 | Protein | denotes | TRADD |
T20602 | 8731-8777 | Protein | denotes | TNF receptor 1-associated death domain protein |
T20601 | 8672-8676 | Protein | denotes | TLR4 |
T20600 | 8662-8666 | Protein | denotes | RANK |
T20599 | 8656-8660 | Protein | denotes | CD40 |
T20598 | 8926-8931 | Protein | denotes | cIAP2 |
T20597 | 8919-8924 | Protein | denotes | cIAP1 |
T20596 | 8912-8917 | Protein | denotes | TRAF6 |
T20595 | 8905-8910 | Protein | denotes | TRAF2 |
T20594 | 8874-8879 | Protein | denotes | IRAK4 |
T20593 | 8867-8872 | Protein | denotes | IRAK1 |
T20592 | 8861-8865 | Protein | denotes | RIP1 |
T20591 | 8844-8848 | Protein | denotes | TRIF |
T20590 | 8649-8654 | Protein | denotes | TNFR1 |
T18550 | 32531-32540 | Localization | denotes | secretion |
T18549 | 32481-32489 | Positive_regulation | denotes | elevated |
T18548 | 32521-32530 | Positive_regulation | denotes | increased |
T18547 | 32421-32430 | Negative_regulation | denotes | decreased |
T18546 | 31672-31679 | Positive_regulation | denotes | promote |
T18545 | 31684-31694 | Gene_expression | denotes | production |
T18544 | 31458-31472 | Positive_regulation | denotes | overexpression |
T18543 | 31373-31379 | Binding | denotes | target |
T18542 | 31269-31278 | Gene_expression | denotes | producing |
T18541 | 31237-31250 | Gene_expression | denotes | overexpressed |
T18540 | 31067-31076 | Gene_expression | denotes | expressed |
T18539 | 30689-30696 | Positive_regulation | denotes | induced |
T18538 | 32659-32666 | Protein | denotes | miR-223 |
T18537 | 32646-32653 | Protein | denotes | miR-132 |
T18536 | 32638-32644 | Protein | denotes | miR-16 |
T18535 | 32575-32579 | Protein | denotes | IL-6 |
T18534 | 32544-32570 | Protein | denotes | matrix metalloproteinase-1 |
T18533 | 32500-32507 | Protein | denotes | miR-203 |
T18532 | 32368-32402 | Protein | denotes | monocyte chemoattractant protein 1 |
T18531 | 32324-32332 | Protein | denotes | miR-124a |
T18530 | 32152-32159 | Protein | denotes | miR-155 |
T18529 | 31754-31761 | Protein | denotes | miR-155 |
T18528 | 31680-31683 | Protein | denotes | TNF |
T18527 | 31651-31658 | Protein | denotes | miR-155 |
T18526 | 31450-31457 | Protein | denotes | miR-155 |
T18525 | 31364-31372 | Protein | denotes | miR-146a |
T18524 | 31263-31268 | Protein | denotes | IL-17 |
T18523 | 31254-31257 | Protein | denotes | CD4 |
T18522 | 31220-31228 | Protein | denotes | miR-146a |
T18521 | 31055-31062 | Protein | denotes | miR-155 |
T18520 | 31015-31019 | Protein | denotes | RIP1 |
T18519 | 31006-31010 | Protein | denotes | IKKε |
T18518 | 30931-30938 | Protein | denotes | miR-155 |
T18517 | 30894-30902 | Protein | denotes | miR-146a |
T18516 | 30853-30858 | Protein | denotes | TRAF6 |
T18515 | 30843-30848 | Protein | denotes | IRAK1 |
T18514 | 30771-30779 | Protein | denotes | miR-146a |
T18513 | 30736-30739 | Protein | denotes | TNF |
T18512 | 30729-30734 | Protein | denotes | IL-1β |
T18511 | 30590-30597 | Protein | denotes | miR-155 |
T18510 | 30584-30585 | Protein | denotes | b |
T18509 | 30575-30583 | Protein | denotes | miR-146a |
T17040 | 30171-30182 | Binding | denotes | association |
T17039 | 29720-29727 | Binding | denotes | recruit |
T17038 | 29761-29769 | Binding | denotes | interact |
T17037 | 29639-29646 | Binding | denotes | binding |
T17036 | 29336-29345 | Negative_regulation | denotes | deficient |
T17035 | 29128-29137 | Negative_regulation | denotes | deficient |
T17034 | 29015-29025 | Gene_expression | denotes | Expression |
T17033 | 29059-29073 | Positive_regulation | denotes | overexpression |
T17032 | 29038-29047 | Positive_regulation | denotes | inducible |
T17031 | 30190-30195 | Protein | denotes | TRAF1 |
T17030 | 30057-30062 | Protein | denotes | TRAF1 |
T17029 | 29955-29960 | Protein | denotes | TRAF1 |
T17028 | 29728-29731 | Protein | denotes | A20 |
T17027 | 29708-29713 | Protein | denotes | TRAF1 |
T17026 | 29595-29600 | Protein | denotes | TRAF1 |
T17025 | 29528-29533 | Protein | denotes | TRAF1 |
T17024 | 29426-29431 | Protein | denotes | TRAF2 |
T17023 | 29330-29335 | Protein | denotes | TRAF1 |
T17022 | 29299-29303 | Protein | denotes | CD40 |
T17021 | 29251-29256 | Protein | denotes | TRAF1 |
T17020 | 29122-29127 | Protein | denotes | TRAF1 |
T17019 | 29170-29173 | Protein | denotes | TNF |
T17018 | 29092-29095 | Protein | denotes | TNF |
T17017 | 29077-29082 | Protein | denotes | TRAF1 |
T17016 | 29051-29054 | Protein | denotes | TNF |
T17015 | 29029-29034 | Protein | denotes | TRAF1 |
T17014 | 28862-28867 | Protein | denotes | TRAF1 |
T17013 | 28798-28807 | Protein | denotes | ubiquitin |
T17012 | 28688-28693 | Protein | denotes | TRAF1 |
T17011 | 28655-28687 | Protein | denotes | TNF receptor-associated factor 1 |
T16083 | 28574-28584 | Gene_expression | denotes | expression |
T16082 | 28640-28646 | Regulation | denotes | target |
T16081 | 28391-28401 | Gene_expression | denotes | expression |
T16080 | 28219-28228 | Negative_regulation | denotes | deficient |
T16079 | 28026-28040 | Positive_regulation | denotes | overexpression |
T16078 | 27898-27907 | Gene_expression | denotes | expressed |
T16077 | 27553-27562 | Negative_regulation | denotes | inhibitor |
T16076 | 27616-27627 | Binding | denotes | interaction |
T16075 | 28594-28600 | Protein | denotes | SIGIRR |
T16074 | 28510-28516 | Protein | denotes | SIGIRR |
T16073 | 28405-28411 | Protein | denotes | SIGIRR |
T16072 | 28212-28218 | Protein | denotes | SIGIRR |
T16064 | 27650-27655 | Protein | denotes | MyD88 |
T16063 | 27566-27571 | Protein | denotes | IL-1R |
T16062 | 27464-27469 | Protein | denotes | TIR-8 |
T16061 | 27433-27439 | Protein | denotes | SIGIRR |
T16060 | 27388-27431 | Protein | denotes | Single-immunoglobulin IL-1 receptor-related |
T16059 | 27336-27379 | Protein | denotes | Single-immunoglobulin IL-1 receptor-related |
T15071 | 26964-26974 | Gene_expression | denotes | expressing |
T15069 | 26658-26669 | Positive_regulation | denotes | upregulated |
T15068 | 26730-26739 | Binding | denotes | recruited |
T15067 | 26876-26892 | Negative_regulation | denotes | deubiquitination |
T15066 | 26635-26645 | Gene_expression | denotes | expression |
T15065 | 26565-26572 | Positive_regulation | denotes | induced |
T15064 | 26406-26416 | Negative_regulation | denotes | deficiency |
T15063 | 25997-26006 | Gene_expression | denotes | expressed |
T15062 | 27244-27248 | Protein | denotes | CYLD |
T15061 | 27135-27139 | Protein | denotes | RANK |
T15060 | 27106-27110 | Protein | denotes | CYLD |
T15059 | 26993-26996 | Protein | denotes | p62 |
T15058 | 26896-26901 | Protein | denotes | TRAF6 |
T15057 | 26862-26866 | Protein | denotes | CYLD |
T15056 | 26824-26838 | Protein | denotes | sequestosome 1 |
T15055 | 26805-26808 | Protein | denotes | p62 |
T15054 | 26771-26780 | Protein | denotes | ubiquitin |
T15053 | 26757-26762 | Protein | denotes | TRAF6 |
T15052 | 26690-26695 | Protein | denotes | RANKL |
T15051 | 26630-26634 | Protein | denotes | CYLD |
T15050 | 26559-26564 | Protein | denotes | RANKL |
T15049 | 26420-26424 | Protein | denotes | CYLD |
T15048 | 26333-26337 | Protein | denotes | RANK |
T15047 | 26290-26294 | Protein | denotes | CYLD |
T15046 | 26143-26147 | Protein | denotes | CYLD |
T15045 | 25985-25988 | Protein | denotes | A20 |
T15044 | 25948-25952 | Protein | denotes | CYLD |
T15043 | 25933-25936 | Protein | denotes | A20 |
T15042 | 25884-25887 | Protein | denotes | A20 |
T15041 | 25813-25818 | Protein | denotes | TRAF2 |
T15040 | 25807-25811 | Protein | denotes | NEMO |
T15039 | 25674-25678 | Protein | denotes | RANK |
T15038 | 25588-25611 | Protein | denotes | deubiquitinating enzyme |
T15037 | 25578-25582 | Protein | denotes | CYLD |
T15036 | 25843-25847 | Protein | denotes | TAK1 |
T15035 | 25834-25838 | Protein | denotes | RIP1 |
T15034 | 25827-25832 | Protein | denotes | TRAF7 |
T15033 | 25820-25825 | Protein | denotes | TRAF6 |
T15032 | 25385-25389 | Protein | denotes | CYLD |
T15031 | 25279-25283 | Protein | denotes | CYLD |
T15030 | 25262-25277 | Protein | denotes | Cylindromatosis |
T15029 | 25238-25253 | Protein | denotes | Cylindromatosis |
T13674 | 24468-24474 | Regulation | denotes | depend |
T13673 | 24482-24492 | Gene_expression | denotes | expression |
T13672 | 24080-24087 | Positive_regulation | denotes | induced |
T13671 | 23887-23894 | Positive_regulation | denotes | induced |
T13670 | 23874-23882 | Negative_regulation | denotes | inhibits |
T13669 | 23922-23931 | Negative_regulation | denotes | deficient |
T13668 | 23752-23759 | Gene_expression | denotes | express |
T13667 | 23717-23726 | Gene_expression | denotes | expressed |
T13666 | 23790-23797 | Negative_regulation | denotes | lacking |
T13665 | 23523-23532 | Negative_regulation | denotes | deficient |
T13664 | 23502-23511 | Negative_regulation | denotes | deficient |
T13663 | 23315-23325 | Gene_expression | denotes | expression |
T13662 | 23229-23235 | Binding | denotes | target |
T13661 | 23013-23024 | Binding | denotes | interacting |
T13660 | 22999-23008 | Gene_expression | denotes | expressed |
T13659 | 22870-22877 | Binding | denotes | binding |
T13658 | 24679-24685 | Protein | denotes | ABIN-1 |
T13657 | 24537-24540 | Protein | denotes | A20 |
T13656 | 24526-24532 | Protein | denotes | ABIN-3 |
T13655 | 24239-24242 | Protein | denotes | A20 |
T13654 | 24217-24223 | Protein | denotes | ABIN-1 |
T13653 | 24136-24142 | Protein | denotes | ABIN-1 |
T13652 | 24076-24079 | Protein | denotes | TNF |
T13651 | 24048-24054 | Protein | denotes | ABIN-1 |
T13650 | 23962-23965 | Protein | denotes | TNF |
T13649 | 23915-23921 | Protein | denotes | ABIN-1 |
T13648 | 23883-23886 | Protein | denotes | TNF |
T13647 | 23853-23859 | Protein | denotes | ABIN-1 |
T13646 | 23848-23851 | Protein | denotes | A20 |
T13645 | 23762-23789 | Protein | denotes | truncated and inactive form |
T13644 | 23707-23713 | Protein | denotes | ABIN-3 |
T13643 | 23516-23522 | Protein | denotes | ABIN-2 |
T13642 | 23495-23501 | Protein | denotes | ABIN-1 |
T13641 | 23383-23386 | Protein | denotes | A20 |
T13640 | 23308-23314 | Protein | denotes | ABIN-3 |
T13639 | 23297-23303 | Protein | denotes | ABIN-1 |
T13638 | 23292-23295 | Protein | denotes | A20 |
T13637 | 23236-23239 | Protein | denotes | A20 |
T13636 | 23080-23083 | Protein | denotes | TNF |
T13635 | 23009-23012 | Protein | denotes | A20 |
T13634 | 22959-22965 | Protein | denotes | TNIP-3 |
T13633 | 22947-22953 | Protein | denotes | TNIP-2 |
T13632 | 22939-22945 | Protein | denotes | TNIP-1 |
T13631 | 22917-22923 | Protein | denotes | ABIN-3 |
T13630 | 22906-22912 | Protein | denotes | ABIN-2 |
T13629 | 22898-22904 | Protein | denotes | ABIN-1 |
T11762 | 18753-18756 | Protein | denotes | A20 |
T11761 | 18691-18694 | Protein | denotes | A20 |
T11760 | 18634-18635 | Protein | denotes | 2 |
T11759 | 18628-18633 | Protein | denotes | cIAP1 |
T11758 | 18618-18623 | Protein | denotes | TRAF2 |
T11757 | 18611-18616 | Protein | denotes | TRAF6 |
T11756 | 18577-18583 | Protein | denotes | Ubc5hc |
T11755 | 18567-18572 | Protein | denotes | Ubc13 |
T11754 | 18388-18392 | Protein | denotes | RIP2 |
T11753 | 18382-18386 | Protein | denotes | RIP1 |
T11752 | 18275-18278 | Protein | denotes | A20 |
T11751 | 18404-18409 | Protein | denotes | MALT1 |
T11750 | 18394-18399 | Protein | denotes | TRAF6 |
T11749 | 18132-18135 | Protein | denotes | TNF |
T11748 | 18038-18043 | Protein | denotes | NF-κB |
T11747 | 17986-18011 | Protein | denotes | ubiquitin-editing protein |
T11746 | 17972-17979 | Protein | denotes | TNFAIP3 |
T11745 | 17953-17956 | Protein | denotes | A20 |
T11744 | 17941-17944 | Protein | denotes | A20 |
T11833 | 22545-22554 | Negative_regulation | denotes | repressed |
T11826 | 21166-21180 | Positive_regulation | denotes | overexpression |
T11810 | 18985-18994 | Negative_regulation | denotes | inhibitor |
T11809 | 18766-18773 | Regulation | denotes | targets |
T11808 | 18774-18782 | Positive_regulation | denotes | requires |
T11807 | 18738-18749 | Binding | denotes | association |
T11806 | 18498-18508 | Negative_regulation | denotes | disruption |
T11805 | 22791-22794 | Protein | denotes | A20 |
T11804 | 22555-22558 | Protein | denotes | A20 |
T11803 | 22507-22510 | Protein | denotes | A20 |
T11802 | 22327-22330 | Protein | denotes | A20 |
T11801 | 22246-22249 | Protein | denotes | A20 |
T11800 | 22208-22216 | Protein | denotes | cytokine |
T11799 | 22176-22179 | Protein | denotes | TNF |
T11798 | 22151-22154 | Protein | denotes | TNF |
T11797 | 22116-22119 | Protein | denotes | A20 |
T11796 | 22029-22032 | Protein | denotes | A20 |
T11795 | 21982-21985 | Protein | denotes | A20 |
T11794 | 21828-21831 | Protein | denotes | A20 |
T11793 | 21607-21610 | Protein | denotes | A20 |
T11792 | 21461-21464 | Protein | denotes | A20 |
T11791 | 21257-21260 | Protein | denotes | A20 |
T11790 | 21162-21165 | Protein | denotes | A20 |
T11789 | 21013-21016 | Protein | denotes | A20 |
T11788 | 21004-21009 | Protein | denotes | IL-1β |
T9148 | 17665-17679 | Phosphorylation | denotes | phosphorylates |
T9147 | 17580-17595 | Phosphorylation | denotes | phosphorylating |
T9146 | 17428-17436 | Positive_regulation | denotes | enhanced |
T9145 | 17302-17311 | Negative_regulation | denotes | deficient |
T9144 | 17418-17424 | Positive_regulation | denotes | result |
T9143 | 17462-17473 | Protein_catabolism | denotes | degradation |
T9142 | 17442-17452 | Positive_regulation | denotes | activation |
T9141 | 17333-17343 | Gene_expression | denotes | expressing |
T9140 | 17781-17785 | Protein | denotes | IKK1 |
T9139 | 17680-17683 | Protein | denotes | NIK |
T9138 | 17660-17664 | Protein | denotes | IKK1 |
T9137 | 17480-17484 | Protein | denotes | IKK1 |
T9136 | 17596-17601 | Protein | denotes | STAT1 |
T9135 | 17457-17461 | Protein | denotes | IκBα |
T9134 | 17437-17441 | Protein | denotes | IKK2 |
T9133 | 17353-17357 | Protein | denotes | IKK1 |
T9132 | 17297-17301 | Protein | denotes | IKK1 |
T9131 | 17069-17073 | Protein | denotes | IKK1 |
T9130 | 16915-16921 | Protein | denotes | TOLLIP |
T9129 | 16903-16909 | Protein | denotes | IRAK-M |
T9128 | 16895-16901 | Protein | denotes | MyD88s |
T7083 | 15812-15820 | Positive_regulation | denotes | required |
T7082 | 15785-15795 | Gene_expression | denotes | production |
T7081 | 15734-15742 | Positive_regulation | denotes | required |
T7080 | 15362-15370 | Binding | denotes | interact |
T7079 | 13803-13818 | Phosphorylation | denotes | phosphorylation |
T7078 | 13781-13793 | Positive_regulation | denotes | accumulation |
T7077 | 13751-13762 | Protein_catabolism | denotes | degradation |
T7076 | 13764-13773 | Positive_regulation | denotes | resulting |
T7075 | 13715-13724 | Negative_regulation | denotes | releasing |
T7074 | 13533-13539 | Negative_regulation | denotes | remove |
T7073 | 13567-13577 | Binding | denotes | recruiting |
T7072 | 13610-13617 | Binding | denotes | attract |
T7071 | 13647-13656 | Positive_regulation | denotes | essential |
T7070 | 13678-13689 | Protein_catabolism | denotes | degradation |
T7069 | 13457-13468 | Protein_catabolism | denotes | degradation |
T7068 | 13206-13215 | Regulation | denotes | regulated |
T7067 | 13122-13131 | Positive_regulation | denotes | activated |
T7066 | 12588-12596 | Positive_regulation | denotes | activate |
T7065 | 12509-12517 | Binding | denotes | recruits |
T7064 | 12556-12567 | Binding | denotes | interaction |
T7063 | 11999-12010 | Positive_regulation | denotes | stimulation |
T7062 | 12212-12219 | Binding | denotes | recruit |
T7061 | 12033-12040 | Positive_regulation | denotes | induces |
T7060 | 12045-12056 | Binding | denotes | recruitment |
T7059 | 11612-11620 | Regulation | denotes | modifies |
T7058 | 11447-11454 | Binding | denotes | recruit |
T7057 | 11313-11327 | Binding | denotes | ubiquitination |
T7056 | 11197-11202 | Binding | denotes | bound |
T7055 | 11071-11075 | Binding | denotes | bind |
T7054 | 10826-10837 | Binding | denotes | recruitment |
T7053 | 8484-8492 | Positive_regulation | denotes | required |
T7052 | 15890-15894 | Protein | denotes | CD40 |
T7051 | 15850-15855 | Protein | denotes | TRAF3 |
T7050 | 15803-15808 | Protein | denotes | TRAF2 |
T7049 | 15780-15784 | Protein | denotes | IL-6 |
T7048 | 15747-15751 | Protein | denotes | CD40 |
T7047 | 15725-15730 | Protein | denotes | TRAF6 |
T7046 | 15676-15680 | Protein | denotes | CD40 |
T7045 | 15499-15504 | Protein | denotes | TRAF3 |
T7044 | 15489-15494 | Protein | denotes | TRAF2 |
T7043 | 15440-15445 | Protein | denotes | TRAF6 |
T7042 | 15429-15434 | Protein | denotes | TRAF5 |
T7041 | 15422-15427 | Protein | denotes | TRAF3 |
T7040 | 15415-15420 | Protein | denotes | TRAF2 |
T7011 | 12780-12784 | Protein | denotes | CD40 |
T7010 | 12765-12778 | Protein | denotes | BAFF receptor |
T7009 | 12741-12763 | Protein | denotes | lymphotoxin β receptor |
T7008 | 12662-12665 | Protein | denotes | TNF |
T7007 | 12597-12601 | Protein | denotes | TAK1 |
T7006 | 12533-12537 | Protein | denotes | RIP1 |
T7005 | 12518-12523 | Protein | denotes | TRAF6 |
T7004 | 12499-12503 | Protein | denotes | TRIF |
T7003 | 12487-12492 | Protein | denotes | TRAF6 |
T7002 | 12427-12432 | Protein | denotes | TRAF6 |
T7001 | 12347-12352 | Protein | denotes | MyD88 |
T7000 | 12326-12330 | Protein | denotes | TRIF |
T6999 | 12281-12324 | Protein | denotes | TIR domain-containing adaptor-inducing IFNβ |
T6998 | 12270-12275 | Protein | denotes | MyD88 |
T6997 | 12220-12268 | Protein | denotes | myeloid differentiation primary response gene 88 |
T6996 | 12156-12160 | Protein | denotes | TRAM |
T6995 | 12125-12154 | Protein | denotes | TRIF-related adaptor molecule |
T6994 | 12116-12118 | Protein | denotes | Ma |
T6993 | 12060-12094 | Protein | denotes | Toll/IL-1 receptor adaptor protein |
T6992 | 11994-11998 | Protein | denotes | TLR4 |
T6991 | 11906-11910 | Protein | denotes | TAK1 |
T6990 | 11680-11683 | Protein | denotes | TNF |
T6989 | 11621-11625 | Protein | denotes | NEMO |
T6988 | 11529-11530 | Protein | denotes | 2 |
T6987 | 11524-11528 | Protein | denotes | TAB1 |
T6986 | 11515-11519 | Protein | denotes | NEMO |
T6985 | 11467-11471 | Protein | denotes | TAK1 |
T6984 | 11405-11409 | Protein | denotes | RIP1 |
T6983 | 11308-11312 | Protein | denotes | RIP1 |
T6982 | 11282-11283 | Protein | denotes | 2 |
T6981 | 11276-11281 | Protein | denotes | cIAP1 |
T6980 | 11270-11271 | Protein | denotes | 5 |
T6979 | 11264-11269 | Protein | denotes | TRAF2 |
T6978 | 11203-11207 | Protein | denotes | RIP1 |
T6977 | 11167-11170 | Protein | denotes | TNF |
T6976 | 11146-11151 | Protein | denotes | cIAP2 |
T6975 | 11101-11141 | Protein | denotes | cellular inhibitor of apoptosis (cIAP) 1 |
T6974 | 11050-11055 | Protein | denotes | TRAF5 |
T6973 | 11006-11045 | Protein | denotes | TNF receptor-associated factor (TRAF) 2 |
T6972 | 10935-10939 | Protein | denotes | RIP1 |
T6971 | 10903-10933 | Protein | denotes | receptor interacting protein 1 |
T6970 | 10881-10886 | Protein | denotes | TRADD |
T6969 | 10841-10879 | Protein | denotes | TNF receptor-1-associated death domain |
T6968 | 10795-10798 | Protein | denotes | TNF |
T6967 | 10782-10785 | Protein | denotes | TNF |
T6966 | 8474-8478 | Protein | denotes | IKK1 |
T6965 | 8460-8464 | Protein | denotes | NEMO |
T6964 | 8451-8455 | Protein | denotes | IKK2 |
T6963 | 8394-8398 | Protein | denotes | IKKγ |
T6962 | 8373-8377 | Protein | denotes | NEMO |
T6961 | 8346-8371 | Protein | denotes | NF-κB essential modulator |
T6960 | 8313-8317 | Protein | denotes | IKKβ |
T6959 | 8304-8308 | Protein | denotes | IKKα |
T6958 | 8284-8288 | Protein | denotes | IKK2 |
T6957 | 8275-8279 | Protein | denotes | IKK1 |
T6956 | 7830-7835 | Protein | denotes | RANKL |
T6955 | 7808-7811 | Protein | denotes | TNF |
T6954 | 7481-7484 | Protein | denotes | p50 |
T6953 | 7473-7476 | Protein | denotes | p52 |
T6952 | 7446-7450 | Protein | denotes | p105 |
T6951 | 7437-7441 | Protein | denotes | p100 |
T6950 | 7374-7379 | Protein | denotes | Bcl-3 |
T6949 | 7365-7369 | Protein | denotes | IκBξ |
T6948 | 7326-7332 | Protein | denotes | NF-κB2 |
T6947 | 7306-7310 | Protein | denotes | p100 |
T6946 | 7297-7303 | Protein | denotes | NF-κB1 |
T6945 | 7277-7281 | Protein | denotes | p105 |
T6944 | 7271-7275 | Protein | denotes | IκBε |
T6943 | 7265-7269 | Protein | denotes | IκBβ |
T6942 | 7259-7263 | Protein | denotes | IκBα |
T3327 | 6570-6577 | Positive_regulation | denotes | induced |
T3326 | 6147-6156 | Positive_regulation | denotes | increased |
T3325 | 6032-6040 | Localization | denotes | released |
T3324 | 5995-6003 | Localization | denotes | secreted |
T3323 | 4756-4764 | Positive_regulation | denotes | Enhanced |
T3322 | 4765-4775 | Gene_expression | denotes | expression |
T3321 | 4264-4273 | Gene_expression | denotes | expressed |
T3320 | 4207-4214 | Binding | denotes | Binding |
T3319 | 3967-3976 | Gene_expression | denotes | expressed |
T3318 | 4146-4157 | Positive_regulation | denotes | upregulated |
T3317 | 6759-6769 | Protein | denotes | tenascin C |
T3316 | 6749-6757 | Protein | denotes | biglycan |
T3304 | 5011-5033 | Protein | denotes | lymphotoxin β receptor |
T3303 | 4957-4961 | Protein | denotes | BAFF |
T3302 | 4836-4840 | Protein | denotes | BAFF |
T3301 | 4810-4834 | Protein | denotes | B-cell activating factor |
T3300 | 4576-4580 | Protein | denotes | CD40 |
T3299 | 4302-4305 | Protein | denotes | CD4 |
T3298 | 4235-4240 | Protein | denotes | CD154 |
T3297 | 4222-4233 | Protein | denotes | CD40 ligand |
T3296 | 4197-4200 | Protein | denotes | TNF |
T3295 | 3919-3945 | Protein | denotes | TNF receptor family member |
T3294 | 3903-3907 | Protein | denotes | CD40 |
T3293 | 3789-3793 | Protein | denotes | RANK |
T3292 | 3693-3697 | Protein | denotes | RANK |
T3291 | 3664-3691 | Protein | denotes | receptor activator of NF-κB |
T3290 | 3450-3453 | Protein | denotes | TNF |
T3289 | 3375-3378 | Protein | denotes | TNF |
T3288 | 3316-3319 | Protein | denotes | TNF |
T1299 | 1823-1831 | Regulation | denotes | regulate |
T1298 | 1836-1846 | Gene_expression | denotes | expression |
T1297 | 2966-2971 | Protein | denotes | c-REL |
T1296 | 2953-2960 | Protein | denotes | TNFAIP3 |
T1295 | 2946-2951 | Protein | denotes | TRAF1 |
T1294 | 2940-2944 | Protein | denotes | CD40 |
T1293 | 2690-2695 | Protein | denotes | RANKL |
T1292 | 2654-2688 | Protein | denotes | receptor activator of NF-κB ligand |
T1291 | 2035-2038 | Protein | denotes | TNF |
T1290 | 1884-1887 | Protein | denotes | TNF |
T1289 | 1758-1763 | Protein | denotes | c-Rel |
T1288 | 1752-1756 | Protein | denotes | RelB |
T1287 | 1746-1750 | Protein | denotes | RelA |
T1286 | 1739-1742 | Protein | denotes | p65 |
T1285 | 1731-1737 | Protein | denotes | NF-κB1 |
T1284 | 1723-1727 | Protein | denotes | p105 |
T1283 | 1715-1721 | Protein | denotes | NF-κB2 |
T1282 | 1932-1963 | Protein | denotes | inducible nitric oxide synthase |
T1281 | 1901-1918 | Protein | denotes | cyclo-oxygenase-2 |
T1280 | 1895-1899 | Protein | denotes | IL-6 |
T1279 | 1707-1711 | Protein | denotes | p100 |
T3315 | 6736-6747 | Protein | denotes | fibronectin |
T3314 | 6565-6569 | Protein | denotes | TLR4 |
T3313 | 6341-6367 | Protein | denotes | myeloid-related protein 14 |
T3312 | 6311-6336 | Protein | denotes | Myeloid-related protein 8 |
T3311 | 6248-6253 | Protein | denotes | HMGB1 |
T3310 | 6183-6188 | Protein | denotes | HMGB1 |
T3309 | 6138-6143 | Protein | denotes | HMGB1 |
T3308 | 6099-6111 | Protein | denotes | TLR4 ligands |
T3307 | 5954-5973 | Protein | denotes | chromatin component |
T3306 | 5927-5932 | Protein | denotes | HMGB1 |
T3305 | 5880-5925 | Protein | denotes | High mobility group box chromosomal protein 1 |
T7024 | 13389-13394 | Protein | denotes | cIAP1 |
T7023 | 13378-13383 | Protein | denotes | TRAF3 |
T7022 | 13371-13376 | Protein | denotes | TRAF2 |
T7021 | 13330-13333 | Protein | denotes | NIK |
T7020 | 13426-13429 | Protein | denotes | NIK |
T7019 | 13185-13188 | Protein | denotes | NIK |
T7018 | 13179-13182 | Protein | denotes | NIK |
T7017 | 13156-13177 | Protein | denotes | NF-κB inducing kinase |
T7016 | 13107-13111 | Protein | denotes | IKK1 |
T7015 | 12892-12896 | Protein | denotes | RelB |
T7014 | 12863-12866 | Protein | denotes | p52 |
T7013 | 12824-12828 | Protein | denotes | p100 |
T7012 | 12790-12794 | Protein | denotes | RANK |
T7039 | 15408-15413 | Protein | denotes | TRAF1 |
T7038 | 15357-15361 | Protein | denotes | RANK |
T7037 | 15348-15352 | Protein | denotes | CD40 |
T7036 | 15228-15232 | Protein | denotes | RANK |
T7035 | 15201-15223 | Protein | denotes | lymphotoxin β receptor |
T7034 | 15195-15199 | Protein | denotes | CD40 |
T7033 | 13798-13802 | Protein | denotes | IKK1 |
T7032 | 13777-13780 | Protein | denotes | NIK |
T7031 | 13725-13728 | Protein | denotes | NIK |
T7030 | 13672-13677 | Protein | denotes | TRAF3 |
T7029 | 13634-13635 | Protein | denotes | 2 |
T7028 | 13628-13633 | Protein | denotes | cIAP1 |
T7027 | 13618-13623 | Protein | denotes | TRAF2 |
T7026 | 13540-13545 | Protein | denotes | TRAF3 |
T7025 | 13395-13396 | Protein | denotes | 2 |
T11769 | 19360-19363 | Protein | denotes | TNF |
T11768 | 19311-19314 | Protein | denotes | A20 |
T11767 | 19126-19129 | Protein | denotes | A20 |
T11766 | 19062-19065 | Protein | denotes | A20 |
T11765 | 18964-18967 | Protein | denotes | A20 |
T11764 | 18882-18904 | Protein | denotes | Tax1-binding protein 1 |
T11763 | 18838-18877 | Protein | denotes | A20-binding inhibitor of NF-κB (ABIN) 1 |
T11787 | 20996-20999 | Protein | denotes | TNF |
T11786 | 20869-20874 | Protein | denotes | IL-1β |
T11785 | 20861-20864 | Protein | denotes | TNF |
T11784 | 20703-20706 | Protein | denotes | A20 |
T11783 | 20639-20674 | Protein | denotes | monocyte chemo-attractant protein 1 |
T11782 | 20632-20637 | Protein | denotes | RANKL |
T11781 | 20618-20622 | Protein | denotes | IL-6 |
T11780 | 20611-20616 | Protein | denotes | IL-1β |
T11779 | 20606-20609 | Protein | denotes | TNF |
T11778 | 20499-20502 | Protein | denotes | A20 |
T11777 | 20271-20274 | Protein | denotes | A20 |
T11776 | 20168-20171 | Protein | denotes | A20 |
T11775 | 20106-20109 | Protein | denotes | A20 |
T11774 | 19929-19932 | Protein | denotes | A20 |
T11773 | 19798-19801 | Protein | denotes | A20 |
T11772 | 19677-19680 | Protein | denotes | A20 |
T11771 | 19643-19646 | Protein | denotes | TNF |
T11770 | 19483-19486 | Protein | denotes | A20 |
T11816 | 19933-19943 | Gene_expression | denotes | expression |
T11815 | 19790-19797 | Negative_regulation | denotes | lacking |
T11814 | 19475-19482 | Negative_regulation | denotes | lacking |
T11813 | 19647-19654 | Positive_regulation | denotes | induced |
T11812 | 19315-19324 | Negative_regulation | denotes | deficient |
T11811 | 19130-19139 | Negative_regulation | denotes | deficient |
T11825 | 20970-20979 | Negative_regulation | denotes | decreased |
T11824 | 20707-20714 | Positive_regulation | denotes | induces |
T11823 | 20586-20595 | Negative_regulation | denotes | decreased |
T11822 | 20553-20563 | Negative_regulation | denotes | inhibition |
T11821 | 20503-20513 | Gene_expression | denotes | expression |
T11820 | 20836-20846 | Gene_expression | denotes | expression |
T11819 | 20275-20285 | Gene_expression | denotes | expressing |
T11818 | 20131-20140 | Regulation | denotes | regulated |
T11817 | 20110-20120 | Gene_expression | denotes | expression |
T13628 | 22866-22869 | Protein | denotes | A20 |
T11832 | 22559-22572 | Transcription | denotes | transcription |
T11831 | 22123-22131 | Positive_regulation | denotes | required |
T11830 | 22155-22162 | Positive_regulation | denotes | induced |
T11829 | 21972-21981 | Regulation | denotes | influence |
T11828 | 21791-21802 | Binding | denotes | association |
T11827 | 21456-21460 | Negative_regulation | denotes | lack |
T15070 | 26781-26788 | Binding | denotes | binding |
T16071 | 28168-28174 | Protein | denotes | SIGIRR |
T16070 | 28019-28025 | Protein | denotes | SIGIRR |
T16069 | 27843-27849 | Protein | denotes | SIGIRR |
T16068 | 27717-27722 | Protein | denotes | IL-1R |
T16067 | 27813-27819 | Protein | denotes | SIGIRR |
T16066 | 27666-27671 | Protein | denotes | TRAF6 |
T16065 | 27657-27662 | Protein | denotes | IRAK1 |
T22148 | 14432-14450 | Binding | denotes | polyubiquitination |
T20657 | 9988-9995 | Negative_regulation | denotes | compete |
T20656 | 9847-9857 | Gene_expression | denotes | expression |
T20655 | 9836-9846 | Negative_regulation | denotes | inhibiting |
T20654 | 9609-9618 | Binding | denotes | targeting |
T20653 | 9180-9194 | Phosphorylation | denotes | phosphorylates |
T20652 | 9150-9159 | Positive_regulation | denotes | activates |
T20651 | 9131-9145 | Phosphorylation | denotes | phosphorylates |
T20650 | 9063-9074 | Binding | denotes | recruitment |
R1058 | T1281 | T1298 | themeOf | cyclo-oxygenase-2,expression |
R1059 | T1283 | T1299 | causeOf | NF-κB2,regulate |
R1064 | T1298 | T1299 | themeOf | expression,regulate |
R2612 | T3294 | T3319 | themeOf | CD40,expressed |
R2613 | T3295 | T3318 | themeOf | TNF receptor family member,upregulated |
R2614 | T3295 | T3319 | themeOf | TNF receptor family member,expressed |
R2616 | T3297 | T3321 | themeOf | CD40 ligand,expressed |
R2617 | T3297 | T3320 | themeOf | CD40 ligand,Binding |
R2618 | T3298 | T3321 | themeOf | CD154,expressed |
R2619 | T3298 | T3320 | themeOf | CD154,Binding |
R2621 | T3301 | T3322 | themeOf | B-cell activating factor,expression |
R2623 | T3302 | T3322 | themeOf | BAFF,expression |
R2627 | T3305 | T3325 | themeOf | High mobility group box chromosomal protein 1,released |
R2628 | T3307 | T3324 | themeOf | chromatin component,secreted |
R2629 | T3307 | T3325 | themeOf | chromatin component,released |
R2630 | T3309 | T3326 | themeOf | HMGB1,increased |
R2633 | T3314 | T3327 | themeOf | TLR4,induced |
R2637 | T3322 | T3323 | themeOf | expression,Enhanced |
R2638 | T3322 | T3323 | themeOf | expression,Enhanced |
R4903 | T6964 | T7053 | causeOf | IKK2,required |
R4905 | T6965 | T7053 | themeOf | NEMO,required |
R4906 | T6965 | T7053 | themeOf | NEMO,required |
R4907 | T6966 | T7053 | causeOf | IKK1,required |
R4909 | T6969 | T7054 | themeOf | TNF receptor-1-associated death domain,recruitment |
R4910 | T6970 | T7054 | themeOf | TRADD,recruitment |
R4911 | T6971 | T7054 | themeOf | receptor interacting protein 1,recruitment |
R4913 | T6972 | T7054 | themeOf | RIP1,recruitment |
R4915 | T6975 | T7055 | themeOf | cellular inhibitor of apoptosis (cIAP) 1,bind |
R4916 | T6976 | T7055 | themeOf | cIAP2,bind |
R4919 | T6978 | T7056 | themeOf | RIP1,bound |
R4922 | T6983 | T7057 | themeOf | RIP1,ubiquitination |
R4924 | T6986 | T7058 | themeOf | NEMO,recruit |
R4925 | T6987 | T7058 | themeOf | TAB1,recruit |
R4927 | T6988 | T7058 | themeOf | 2,recruit |
R4928 | T6989 | T7059 | themeOf | NEMO,modifies |
R4930 | T6992 | T7063 | themeOf | TLR4,stimulation |
R4932 | T6993 | T7060 | themeOf | Toll/IL-1 receptor adaptor protein,recruitment |
R4933 | T6995 | T7060 | themeOf | TRIF-related adaptor molecule,recruitment |
R4935 | T6996 | T7060 | themeOf | TRAM,recruitment |
R4936 | T6997 | T7062 | themeOf | myeloid differentiation primary response gene 88,recruit |
R4937 | T6998 | T7062 | themeOf | MyD88,recruit |
R4939 | T6999 | T7062 | themeOf | TIR domain-containing adaptor-inducing IFNβ,recruit |
R4940 | T7000 | T7062 | themeOf | TRIF,recruit |
R4942 | T7004 | T7064 | themeOf | TRIF,interaction |
R4944 | T7005 | T7064 | themeOf | TRAF6,interaction |
R4945 | T7005 | T7065 | themeOf | TRAF6,recruits |
R4946 | T7006 | T7065 | themeOf | RIP1,recruits |
R4947 | T7007 | T7066 | themeOf | TAK1,activate |
R4952 | T7016 | T7067 | causeOf | IKK1,activated |
R4954 | T7017 | T7067 | themeOf | NF-κB inducing kinase,activated |
R4956 | T7019 | T7068 | themeOf | NIK,regulated |
R4959 | T7025 | T7069 | themeOf | 2,degradation |
R4960 | T7026 | T7074 | themeOf | TRAF3,remove |
R4961 | T7026 | T7073 | themeOf | TRAF3,recruiting |
R4962 | T7027 | T7072 | themeOf | TRAF2,attract |
R4963 | T7028 | T7072 | themeOf | cIAP1,attract |
R4964 | T7029 | T7072 | themeOf | 2,attract |
R4965 | T7030 | T7070 | themeOf | TRAF3,degradation |
R4966 | T7031 | T7077 | themeOf | NIK,degradation |
R4967 | T7031 | T7075 | themeOf | NIK,releasing |
R4968 | T7032 | T7078 | themeOf | NIK,accumulation |
R4969 | T7033 | T7079 | themeOf | IKK1,phosphorylation |
R4970 | T7037 | T7080 | themeOf | CD40,interact |
R4971 | T7038 | T7080 | themeOf | RANK,interact |
R4972 | T7047 | T7081 | causeOf | TRAF6,required |
R4977 | T7049 | T7082 | themeOf | IL-6,production |
R4986 | T7050 | T7083 | themeOf | TRAF2,required |
R5008 | T7060 | T7061 | themeOf | recruitment,induces |
R5031 | T7060 | T7061 | themeOf | recruitment,induces |
R5038 | T7060 | T7061 | themeOf | recruitment,induces |
R5039 | T7063 | T7061 | causeOf | stimulation,induces |
R5050 | T7063 | T7061 | causeOf | stimulation,induces |
R5051 | T7063 | T7061 | causeOf | stimulation,induces |
R5052 | T7070 | T7071 | themeOf | degradation,essential |
R5067 | T7077 | T7075 | themeOf | degradation,releasing |
R5072 | T7078 | T7076 | themeOf | accumulation,resulting |
R5075 | T7079 | T7076 | themeOf | phosphorylation,resulting |
R5076 | T7082 | T7081 | themeOf | production,required |
R6247 | T9132 | T9145 | themeOf | IKK1,deficient |
R6248 | T9133 | T9141 | themeOf | IKK1,expressing |
R6249 | T9134 | T9142 | themeOf | IKK2,activation |
R6250 | T9135 | T9143 | themeOf | IκBα,degradation |
R6251 | T9136 | T9147 | themeOf | STAT1,phosphorylating |
R6252 | T9139 | T9148 | themeOf | NIK,phosphorylates |
R6253 | T9142 | T9146 | themeOf | activation,enhanced |
R6254 | T9143 | T9144 | themeOf | degradation,result |
R8025 | T11755 | T11806 | themeOf | Ubc13,disruption |
R8028 | T11756 | T11806 | themeOf | Ubc5hc,disruption |
R8030 | T11759 | T11806 | themeOf | cIAP1,disruption |
R8032 | T11762 | T11807 | themeOf | A20,association |
R8036 | T11763 | T11808 | themeOf | A20-binding inhibitor of NF-κB (ABIN) 1,requires |
R8038 | T11765 | T11810 | themeOf | A20,inhibitor |
R8040 | T11767 | T11811 | themeOf | A20,deficient |
R8042 | T11768 | T11812 | themeOf | A20,deficient |
R8045 | T11770 | T11814 | themeOf | A20,lacking |
R8047 | T11771 | T11813 | themeOf | TNF,induced |
R8049 | T11773 | T11815 | themeOf | A20,lacking |
R8050 | T11774 | T11816 | themeOf | A20,expression |
R8051 | T11775 | T11817 | themeOf | A20,expression |
R8053 | T11777 | T11819 | themeOf | A20,expressing |
R8054 | T11778 | T11821 | themeOf | A20,expression |
R8056 | T11779 | T11822 | themeOf | TNF,inhibition |
R8057 | T11779 | T11823 | themeOf | TNF,decreased |
R8058 | T11780 | T11822 | themeOf | IL-1β,inhibition |
R8059 | T11780 | T11823 | themeOf | IL-1β,decreased |
R8060 | T11781 | T11822 | themeOf | IL-6,inhibition |
R8061 | T11781 | T11823 | themeOf | IL-6,decreased |
R8062 | T11782 | T11823 | themeOf | RANKL,decreased |
R8064 | T11783 | T11823 | themeOf | monocyte chemo-attractant protein 1,decreased |
R8065 | T11784 | T11824 | themeOf | A20,induces |
R8066 | T11784 | T11820 | themeOf | A20,expression |
R8068 | T11787 | T11825 | themeOf | TNF,decreased |
R8069 | T11788 | T11825 | themeOf | IL-1β,decreased |
R8071 | T11790 | T11826 | themeOf | A20,overexpression |
R8073 | T11792 | T11827 | themeOf | A20,lack |
R8074 | T11794 | T11828 | themeOf | A20,association |
R8076 | T11795 | T11829 | themeOf | A20,influence |
R8078 | T11797 | T11831 | themeOf | A20,required |
R8079 | T11798 | T11830 | themeOf | TNF,induced |
R8082 | T11804 | T11832 | themeOf | A20,transcription |
R8084 | T11807 | T11809 | themeOf | association,targets |
R8085 | T11807 | T11808 | causeOf | association,requires |
R8093 | T11817 | T11818 | themeOf | expression,regulated |
R8095 | T11822 | T11823 | themeOf | inhibition,decreased |
R8096 | T11822 | T11823 | themeOf | inhibition,decreased |
R8097 | T11822 | T11823 | themeOf | inhibition,decreased |
R8101 | T11832 | T11833 | themeOf | transcription,repressed |
R9156 | T13628 | T13659 | themeOf | A20,binding |
R9157 | T13630 | T13660 | themeOf | ABIN-2,expressed |
R9158 | T13635 | T13661 | themeOf | A20,interacting |
R9159 | T13635 | T13660 | themeOf | A20,expressed |
R9160 | T13637 | T13662 | themeOf | A20,target |
R9161 | T13639 | T13663 | themeOf | ABIN-1,expression |
R9162 | T13640 | T13663 | themeOf | ABIN-3,expression |
R9163 | T13642 | T13664 | themeOf | ABIN-1,deficient |
R9164 | T13643 | T13665 | themeOf | ABIN-2,deficient |
R9165 | T13644 | T13667 | themeOf | ABIN-3,expressed |
R9166 | T13645 | T13668 | themeOf | truncated and inactive form,express |
R9167 | T13645 | T13666 | themeOf | truncated and inactive form,lacking |
R9168 | T13646 | T13670 | themeOf | A20,inhibits |
R9169 | T13647 | T13670 | causeOf | ABIN-1,inhibits |
R9170 | T13648 | T13671 | themeOf | TNF,induced |
R9171 | T13649 | T13669 | themeOf | ABIN-1,deficient |
R9172 | T13652 | T13672 | themeOf | TNF,induced |
R9173 | T13656 | T13673 | themeOf | ABIN-3,expression |
R9174 | T13657 | T13673 | themeOf | A20,expression |
R9175 | T13673 | T13674 | themeOf | expression,depend |
R9176 | T13673 | T13674 | themeOf | expression,depend |
R10041 | T15045 | T15063 | themeOf | A20,expressed |
R10042 | T15049 | T15064 | themeOf | CYLD,deficiency |
R10043 | T15050 | T15065 | themeOf | RANKL,induced |
R10044 | T15051 | T15066 | themeOf | CYLD,expression |
R10045 | T15054 | T15070 | themeOf | ubiquitin,binding |
R10046 | T15055 | T15068 | themeOf | p62,recruited |
R10047 | T15055 | T15070 | themeOf | p62,binding |
R10048 | T15058 | T15067 | themeOf | TRAF6,deubiquitination |
R10049 | T15059 | T15071 | themeOf | p62,expressing |
R10050 | T15066 | T15069 | themeOf | expression,upregulated |
R10665 | T16060 | T16076 | themeOf | Single-immunoglobulin IL-1 receptor-related,interaction |
R10666 | T16061 | T16076 | themeOf | SIGIRR,interaction |
R10667 | T16062 | T16076 | themeOf | TIR-8,interaction |
R10668 | T16063 | T16076 | themeOf | IL-1R,interaction |
R10669 | T16065 | T16077 | themeOf | IRAK1,inhibitor |
R10670 | T16065 | T16076 | themeOf | IRAK1,interaction |
R10671 | T16069 | T16078 | themeOf | SIGIRR,expressed |
R10672 | T16070 | T16079 | themeOf | SIGIRR,overexpression |
R10673 | T16072 | T16080 | themeOf | SIGIRR,deficient |
R10674 | T16073 | T16081 | themeOf | SIGIRR,expression |
R10675 | T16075 | T16082 | themeOf | SIGIRR,target |
R10676 | T16075 | T16083 | themeOf | SIGIRR,expression |
R11281 | T17015 | T17034 | themeOf | TRAF1,Expression |
R11282 | T17016 | T17032 | causeOf | TNF,inducible |
R11283 | T17017 | T17033 | themeOf | TRAF1,overexpression |
R11284 | T17020 | T17035 | themeOf | TRAF1,deficient |
R11285 | T17023 | T17036 | themeOf | TRAF1,deficient |
R11286 | T17026 | T17037 | themeOf | TRAF1,binding |
R11287 | T17027 | T17039 | themeOf | TRAF1,recruit |
R11288 | T17028 | T17038 | themeOf | A20,interact |
R11289 | T17028 | T17039 | themeOf | A20,recruit |
R11290 | T17031 | T17040 | themeOf | TRAF1,association |
R11291 | T17034 | T17032 | themeOf | Expression,inducible |
R12357 | T18512 | T18539 | themeOf | IL-1β,induced |
R12358 | T18513 | T18539 | causeOf | TNF,induced |
R12359 | T18521 | T18540 | themeOf | miR-155,expressed |
R12360 | T18522 | T18541 | themeOf | miR-146a,overexpressed |
R12361 | T18524 | T18542 | themeOf | IL-17,producing |
R12362 | T18525 | T18543 | themeOf | miR-146a,target |
R12363 | T18526 | T18544 | themeOf | miR-155,overexpression |
R12364 | T18528 | T18545 | themeOf | TNF,production |
R12365 | T18531 | T18547 | themeOf | miR-124a,decreased |
R12366 | T18533 | T18549 | themeOf | miR-203,elevated |
R12367 | T18534 | T18548 | themeOf | matrix metalloproteinase-1,increased |
R12368 | T18534 | T18550 | themeOf | matrix metalloproteinase-1,secretion |
R12369 | T18535 | T18548 | themeOf | IL-6,increased |
R12370 | T18535 | T18550 | themeOf | IL-6,secretion |
R12371 | T18545 | T18546 | themeOf | production,promote |
R12372 | T18550 | T18548 | themeOf | secretion,increased |
R12373 | T18550 | T18548 | themeOf | secretion,increased |
R13674 | T20590 | T20647 | themeOf | TNFR1,engagement |
R13675 | T20591 | T20646 | themeOf | TRIF,recruitment |
R13676 | T20592 | T20646 | themeOf | RIP1,recruitment |
R13677 | T20593 | T20646 | themeOf | IRAK1,recruitment |
R13678 | T20594 | T20646 | themeOf | IRAK4,recruitment |
R13679 | T20595 | T20646 | themeOf | TRAF2,recruitment |
R13680 | T20596 | T20646 | themeOf | TRAF6,recruitment |
R13681 | T20597 | T20646 | themeOf | cIAP1,recruitment |
R13682 | T20598 | T20646 | themeOf | cIAP2,recruitment |
R13683 | T20601 | T20647 | themeOf | TLR4,engagement |
R13684 | T20602 | T20646 | themeOf | TNF receptor 1-associated death domain protein,recruitment |
R13685 | T20603 | T20646 | themeOf | TRADD,recruitment |
R13686 | T20604 | T20646 | themeOf | MyD88,recruitment |
R13687 | T20605 | T20646 | themeOf | MAL,recruitment |
R13688 | T20606 | T20646 | themeOf | TIR domain-containing adaptor-inducing IFNβ,recruitment |
R13689 | T20607 | T20649 | themeOf | RIP1,polyubiquitination |
R13690 | T20608 | T20649 | themeOf | IRAK1,polyubiquitination |
R13691 | T20610 | T20650 | themeOf | IKK2,recruitment |
R13692 | T20611 | T20650 | themeOf | TAK1,recruitment |
R13693 | T20612 | T20651 | themeOf | TAK1,phosphorylates |
R13694 | T20612 | T20652 | causeOf | TAK1,activates |
R13695 | T20613 | T20651 | themeOf | IKK2,phosphorylates |
R13696 | T20613 | T20652 | themeOf | IKK2,activates |
R13697 | T20614 | T20653 | themeOf | IκBα,phosphorylates |
R13698 | T20620 | T20654 | themeOf | RIP1,targeting |
R13699 | T20624 | T20656 | themeOf | IRAK1,expression |
R13700 | T20625 | T20656 | themeOf | TRAF6,expression |
R13701 | T20626 | T20659 | themeOf | SIGIRR,inhibited |
R13702 | T20627 | T20657 | themeOf | TLR4,compete |
R13703 | T20627 | T20658 | themeOf | TLR4,binding |
R13704 | T20627 | T20658 | themeOf | TLR4,binding |
R13705 | T20628 | T20658 | themeOf | IRAK1,binding |
R13706 | T20629 | T20658 | themeOf | TRAF6,binding |
R13707 | T20650 | T20648 | themeOf | recruitment,resulting |
R13708 | T20650 | T20648 | themeOf | recruitment,resulting |
R13709 | T20656 | T20655 | themeOf | expression,inhibiting |
R13710 | T20656 | T20655 | themeOf | expression,inhibiting |
R13711 | T20658 | T20657 | themeOf | binding,compete |
R13712 | T20658 | T20657 | themeOf | binding,compete |
R14446 | T22109 | T22141 | themeOf | NF-κB inducing kinase,dependent |
R14447 | T22109 | T22142 | themeOf | NF-κB inducing kinase,expression |
R14448 | T22110 | T22142 | themeOf | NIK,expression |
R14449 | T22111 | T22143 | themeOf | NIK,polyubiquitination |
R14450 | T22111 | T22144 | themeOf | NIK,degradation |
R14451 | T22118 | T22145 | themeOf | TRAF3,recruited |
R14452 | T22120 | T22147 | themeOf | cIAP1,polyubiquitination |
R14453 | T22120 | T22146 | themeOf | cIAP1,activation |
R14454 | T22121 | T22147 | themeOf | 2,polyubiquitination |
R14455 | T22124 | T22148 | themeOf | TRAF3,polyubiquitination |
R14456 | T22125 | T22148 | themeOf | NIK,polyubiquitination |
R14457 | T22126 | T22149 | themeOf | TRAF3,degraded |
R14458 | T22128 | T22150 | themeOf | NIK,increased |
R14459 | T22129 | T22153 | themeOf | NIK,phosphorylates |
R14460 | T22129 | T22154 | causeOf | NIK,activates |
R14461 | T22130 | T22153 | themeOf | IKK1,phosphorylates |
R14462 | T22130 | T22154 | themeOf | IKK1,activates |
R14463 | T22130 | T22151 | causeOf | IKK1,mediates |
R14464 | T22131 | T22152 | themeOf | p100,phosphorylation |
R14465 | T22132 | T22155 | themeOf | p100,degradation |
R14466 | T22133 | T22155 | themeOf | p52,degradation |
R14467 | T22142 | T22141 | themeOf | expression,dependent |
R14468 | T22142 | T22141 | themeOf | expression,dependent |
R14469 | T22152 | T22151 | themeOf | phosphorylation,mediates |
bionlp-st-ge-2016-test-ihmc
Id | Subject | Object | Predicate | Lexical cue | Speculation |
---|---|---|---|---|---|
T236 | 23-28 | Protein | denotes | NF-κB | |
T22486 | 14491-14508 | Protein_catabolism | denotes | TRAF3 is degraded | |
T22485 | 13956-13997 | Gene_expression | denotes | on NF-κB inducing kinase (NIK) expression | |
T22484 | 14638-14664 | Phosphorylation | denotes | NF-κB p100 phosphorylation | |
T22483 | 14167-14221 | Protein_catabolism | denotes | proteasomal degradation of NIK, keeping NIK levels low | |
T22482 | 14228-14252 | Binding | denotes | ligand binding, TRAF3 is | |
T22481 | 14417-14450 | Binding | denotes | its K48-linked polyubiquitination | |
T22480 | 14720-14767 | Protein_catabolism | denotes | partial proteasomal degradation of p100 to p52, | |
T22479 | 14280-14386 | Regulation | denotes | where TRAF2 directs nondegradative K63-linked polyubiquitination of cIAP1/2, resulting in their activation | |
T22478 | 14579-14622 | Positive_regulation | denotes | NIK then phosphorylates and activates IKK1, | |
T22477 | 14388-14476 | Regulation | denotes | Subsequently cIAP1/2 directs its K48-linked polyubiquitination to TRAF3, rather than NIK | |
T22476 | 14623-14664 | Regulation | denotes | which mediates NF-κB p100 phosphorylation | |
T22475 | 14513-14530 | Regulation | denotes | NIK is stabilised | |
T22474 | 15106-15141 | Binding | denotes | TNF receptor-associated factor; TNF | |
T22473 | 15106-15109 | Protein | denotes | TNF | |
T22472 | 14989-14993 | Protein | denotes | cIAP | |
T22471 | 13907-13997 | Protein | denotes | the noncanonical NF-κB pathway that is dependent on NF-κB inducing kinase (NIK) expression | |
T22470 | 14228-14234 | Entity | denotes | ligand | |
T22469 | 14760-14767 | Protein | denotes | to p52, | |
T22468 | 14794-14803 | Protein | denotes | with RelB | |
T22467 | 13959-13986 | Protein | denotes | NF-κB inducing kinase (NIK) | |
T22466 | 14491-14496 | Protein | denotes | TRAF3 | |
T22465 | 14421-14431 | Entity | denotes | K48-linked | |
T22464 | 14133-14143 | Entity | denotes | K48-linked | |
T22463 | 14401-14408 | Protein | denotes | cIAP1/2 | |
T22462 | 14579-14582 | Protein | denotes | NIK | |
T22461 | 15065-15070 | Protein | denotes | RANK, | |
T22460 | 14454-14459 | Protein | denotes | TRAF3 | |
T22459 | 14009-14027 | Entity | denotes | unstimulated cells | |
T22458 | 14960-14979 | Protein | denotes | receptor-associated | |
T22457 | 14638-14643 | Protein | denotes | NF-κB | |
T22456 | 14839-14844 | Protein | denotes | TRAF3 | |
T22455 | 14407-14408 | Protein | denotes | 2 | |
T22454 | 13982-13985 | Protein | denotes | NIK | |
T22453 | 14092-14097 | Protein | denotes | TRAF3 | |
T22452 | 14846-14851 | Protein | denotes | TRAF1 | |
T22451 | 14401-14408 | Protein | denotes | cIAP1/2 | |
T22450 | 14569-14577 | Entity | denotes | the cell | |
T22449 | 14617-14622 | Protein | denotes | IKK1, | |
T22448 | 14348-14386 | Protein | denotes | cIAP1/2, resulting in their activation | |
T22447 | 15106-15129 | Protein | denotes | TNF receptor-associated | |
T22446 | 15100-15142 | Protein | denotes | TRAF, TNF receptor-associated factor; TNF, | |
T22445 | 14752-14759 | Protein | denotes | of p100 | |
T22444 | 15106-15141 | Protein | denotes | TNF receptor-associated factor; TNF | |
T22443 | 14063-14090 | Protein | denotes | the ubiquitin ligases TRAF2 | |
T22442 | 14102-14110 | Protein | denotes | cIAP1/2, | |
T22441 | 14473-14476 | Protein | denotes | NIK | |
T22440 | 14038-14110 | Entity | denotes | a cytosolic complex with the ubiquitin ligases TRAF2, TRAF3 and cIAP1/2, | |
T22439 | 15045-15165 | Protein | denotes | NF, nuclear factor; RANK, receptor activator of NF-κB; TRAF, TNF receptor-associated factor; TNF, tumour necrosis factor | |
T22438 | 14286-14291 | Protein | denotes | TRAF2 | |
T22437 | 14555-14558 | Protein | denotes | NIK | |
T22436 | 14207-14210 | Protein | denotes | NIK | |
T22435 | 13889-13893 | Protein | denotes | RANK | |
T22434 | 14956-14959 | Protein | denotes | TNF | |
T22433 | 14995-15043 | Entity | denotes | cellular inhibitor of apoptosis; IKK, IκB kinase | |
T22432 | 15045-15165 | Protein | denotes | NF, nuclear factor; RANK, receptor activator of NF-κB; TRAF, TNF receptor-associated factor; TNF, tumour necrosis factor | |
T22431 | 14244-14249 | Protein | denotes | TRAF3 | |
T22430 | 13880-13884 | Protein | denotes | CD40 | |
T22429 | 14513-14516 | Protein | denotes | NIK | |
T22428 | 14780-14829 | Entity | denotes | a heterodimer with RelB to activate transcription | |
T22427 | 14028-14031 | Protein | denotes | NIK | |
T22426 | 14191-14221 | Protein | denotes | of NIK, keeping NIK levels low | |
T22425 | 14063-14090 | Protein | denotes | the ubiquitin ligases TRAF2 | |
T22424 | 15017-15043 | Protein | denotes | apoptosis; IKK, IκB kinase | |
T22423 | 14638-14648 | Protein | denotes | NF-κB p100 | |
T22422 | 14266-14279 | Protein | denotes | the receptor, | |
T22421 | 14067-14076 | Protein | denotes | ubiquitin | |
T22420 | 14686-14696 | Entity | denotes | K48-linked | |
T22419 | 14315-14325 | Entity | denotes | K63-linked | |
T21192 | 10038-10118 | Regulation | denotes | The expression of many of these negative regulatory molecules is NF-κB dependent | |
T21191 | 9914-9960 | Negative_regulation | denotes | inhibited by the transmembrane protein SIGIRR, | |
T21190 | 9121-9165 | Positive_regulation | denotes | TAK1 then phosphorylates and activates IKK2, | |
T21189 | 9847-9876 | Gene_expression | denotes | expression of IRAK1 and TRAF6 | |
T21188 | 9847-9876 | Gene_expression | denotes | expression of IRAK1 and TRAF6 | |
T21187 | 9166-9200 | Phosphorylation | denotes | which in turn phosphorylates IκBα, | |
T21186 | 10010-10036 | Binding | denotes | binding to IRAK1 and TRAF6 | |
T21185 | 9708-9756 | Binding | denotes | specific ubiquitin-binding adaptor proteins such | |
T21184 | 10173-10192 | Positive_regulation | denotes | of NF-κB activation | |
T21183 | 8950-9005 | Ubiquitination | denotes | K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1, | |
T21182 | 8950-9005 | Ubiquitination | denotes | K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1, | |
T21181 | 8950-9005 | Ubiquitination | denotes | K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1, | |
T21180 | 9471-9488 | Positive_regulation | denotes | NF-κB activation, | |
T21179 | 9576-9672 | Regulation | denotes | that control NF-κB activation by targeting specific signalling proteins including RIP1 and TRAF6 | |
T21178 | 9674-9774 | Binding | denotes | to which they are recruited using specific ubiquitin-binding adaptor proteins such as ABIN-1 and p62 | |
T21177 | 9447-9532 | Regulation | denotes | can negatively regulate NF-κB activation, most probably by competing with other TRAFs | |
T21176 | 9334-9398 | Positive_regulation | denotes | to translocate to the nucleus and promote target gene expression | |
T21175 | 9836-9876 | Negative_regulation | denotes | inhibiting expression of IRAK1 and TRAF6 | |
T21174 | 9836-9876 | Negative_regulation | denotes | inhibiting expression of IRAK1 and TRAF6 | |
T21173 | 8622-8641 | Localization | denotes | membrane receptors | |
T21172 | 10194-10230 | Protein | denotes | ABIN, A20-binding inhibitor of NF-κB | |
T21171 | 8779-8784 | Protein | denotes | TRADD | |
T21170 | 10053-10099 | Entity | denotes | of many of these negative regulatory molecules | |
T21169 | 10336-10455 | Protein | denotes | IRAK, IL-1R-associated kinase; MyD88, myeloid differentiation primary response gene 88; NEMO, NF-κB essential modulator | |
T21168 | 10061-10099 | Entity | denotes | of these negative regulatory molecules | |
T21167 | 9871-9876 | Protein | denotes | TRAF6 | |
T21166 | 9115-9119 | Protein | denotes | TAK1 | |
T21165 | 9760-9766 | Protein | denotes | ABIN-1 | |
T21164 | 9160-9165 | Protein | denotes | IKK2, | |
T21163 | 9708-9756 | Protein | denotes | specific ubiquitin-binding adaptor proteins such | |
T21162 | 9924-9952 | Protein | denotes | by the transmembrane protein | |
T21161 | 9023-9027 | Protein | denotes | NEMO | |
T21160 | 10457-10548 | Protein | denotes | NF, nuclear factor; RANK, receptor activator of NF-κB; RIP1, receptor interacting protein 1 | |
T21159 | 10194-10199 | Protein | denotes | ABIN, | |
T21158 | 10550-10557 | Protein | denotes | SIGIRR, | |
T21157 | 10299-10309 | Protein | denotes | IκB kinase | |
T21156 | 10639-10662 | Protein | denotes | TNF receptor-associated | |
T21155 | 9914-9960 | Protein | denotes | inhibited by the transmembrane protein SIGIRR, | |
T21154 | 10021-10026 | Protein | denotes | IRAK1 | |
T21153 | 9861-9866 | Protein | denotes | IRAK1 | |
T21152 | 10176-10181 | Protein | denotes | NF-κB | |
T21151 | 10336-10341 | Protein | denotes | IRAK, | |
T21150 | 8861-8873 | Protein | denotes | RIP1, IRAK1, | |
T21149 | 9106-9110 | Protein | denotes | IKK2 | |
T21148 | 8950-8960 | Entity | denotes | K63-linked | |
T21147 | 10424-10429 | Protein | denotes | NEMO, | |
T21146 | 9417-9436 | Protein | denotes | no ubiquitin ligase | |
T21145 | 8662-8666 | Protein | denotes | RANK | |
T21144 | 8649-8654 | Protein | denotes | TNFR1 | |
T21143 | 9216-9226 | Entity | denotes | K48-linked | |
T21142 | 10696-10700 | Protein | denotes | TNF, | |
T21141 | 8999-9004 | Protein | denotes | IRAK1 | |
T21140 | 10336-10455 | Protein | denotes | IRAK, IL-1R-associated kinase; MyD88, myeloid differentiation primary response gene 88; NEMO, NF-κB essential modulator | |
T21139 | 8867-8872 | Protein | denotes | IRAK1 | |
T21138 | 8731-8785 | Protein | denotes | TNF receptor 1-associated death domain protein (TRADD) | |
T21137 | 8919-8932 | Protein | denotes | cIAP1, cIAP2) | |
T21136 | 9996-10005 | Protein | denotes | with TLR4 | |
T21135 | 10676-10723 | Protein | denotes | Toll-like receptor; TNF, tumour necrosis factor | |
T21134 | 8905-8911 | Protein | denotes | TRAF2, | |
T21133 | 9771-9774 | Protein | denotes | p62 | |
T21132 | 10457-10548 | Protein | denotes | NF, nuclear factor; RANK, receptor activator of NF-κB; RIP1, receptor interacting protein 1 | |
T21131 | 10367-10373 | Protein | denotes | MyD88, | |
T21130 | 10633-10638 | Protein | denotes | TRAF, | |
T21129 | 9551-9672 | Protein | denotes | deubiquitinating enzymes that control NF-κB activation by targeting specific signalling proteins including RIP1 and TRAF6 | |
T21128 | 9321-9324 | Protein | denotes | p65 | |
T21127 | 8592-8598 | Entity | denotes | Ligand | |
T21126 | 8886-8903 | Protein | denotes | ubiquitin ligases | |
T21125 | 8852-8881 | Protein | denotes | kinases (RIP1, IRAK1, IRAK4), | |
T21124 | 8886-8895 | Protein | denotes | ubiquitin | |
T21123 | 10342-10346 | Protein | denotes | IL-1 | |
T21122 | 10232-10236 | Protein | denotes | cIAP | |
T21121 | 9735-9751 | Protein | denotes | adaptor proteins | |
T21120 | 9283-9288 | Protein | denotes | NF-κB | |
T21119 | 10676-10723 | Protein | denotes | Toll-like receptor; TNF, tumour necrosis factor | |
T21118 | 8622-8630 | Entity | denotes | membrane | |
T21117 | 8794-8850 | Protein | denotes | MAL, TIR domain-containing adaptor-inducing IFNβ (TRIF)) | |
T21116 | 8672-8676 | Protein | denotes | TLR4 | |
T21115 | 9352-9363 | Entity | denotes | the nucleus | |
T21114 | 10550-10625 | Protein | denotes | SIGIRR, single-immunoglobulinIL-1 receptor-related; TIR, Toll-like receptor | |
T21113 | 10639-10642 | Protein | denotes | TNF | |
T21112 | 10512-10517 | Protein | denotes | RIP1, | |
T21111 | 10271-10292 | Protein | denotes | CYLD, cylindromatosis | |
T21110 | 9195-9200 | Protein | denotes | IκBα, | |
T21109 | 8905-8918 | Protein | denotes | TRAF2, TRAF6, | |
T21108 | 10329-10334 | Protein | denotes | NF-κB | |
T21107 | 10550-10625 | Protein | denotes | SIGIRR, single-immunoglobulinIL-1 receptor-related; TIR, Toll-like receptor | |
T21106 | 9471-9476 | Protein | denotes | NF-κB | |
T21105 | 9329-9332 | Protein | denotes | p50 | |
T21104 | 9589-9605 | Protein | denotes | NF-κB activation | |
T21103 | 8940-8948 | Protein | denotes | receptor | |
T21102 | 9304-9332 | Entity | denotes | a heterodimer of p65 and p50 | |
T21101 | 8656-8660 | Protein | denotes | CD40 | |
T21100 | 8799-8849 | Protein | denotes | TIR domain-containing adaptor-inducing IFNβ (TRIF) | |
T21099 | 9619-9647 | Protein | denotes | specific signalling proteins | |
T21098 | 10626-10630 | Protein | denotes | IL-1 | |
T21097 | 10316-10334 | Entity | denotes | inhibitor of NF-κB | |
T21096 | 9542-9546 | Protein | denotes | CYLD | |
T21095 | 9516-9532 | Protein | denotes | with other TRAFs | |
T21094 | 8861-8879 | Protein | denotes | RIP1, IRAK1, IRAK4 | |
T21093 | 9420-9429 | Protein | denotes | ubiquitin | |
T21092 | 8926-8931 | Protein | denotes | cIAP2 | |
T21091 | 10336-10455 | Protein | denotes | IRAK, IL-1R-associated kinase; MyD88, myeloid differentiation primary response gene 88; NEMO, NF-κB essential modulator | |
T21090 | 10602-10606 | Protein | denotes | TIR, | |
T21089 | 10103-10118 | Protein | denotes | NF-κB dependent | |
T21088 | 8990-8994 | Protein | denotes | RIP1 | |
T21087 | 10271-10276 | Protein | denotes | CYLD, | |
T21086 | 9400-9446 | Protein | denotes | TRAF1, which has no ubiquitin ligase activity, | |
T21085 | 10336-10455 | Protein | denotes | IRAK, IL-1R-associated kinase; MyD88, myeloid differentiation primary response gene 88; NEMO, NF-κB essential modulator | |
T21084 | 9121-9125 | Protein | denotes | TAK1 | |
T21083 | 8540-8590 | Protein | denotes | Canonical NF-κB signalling and negative regulators | |
T21082 | 10238-10256 | Entity | denotes | cellular inhibitor | |
T21081 | 9036-9044 | Protein | denotes | proteins | |
T21080 | 9776-9783 | Entity | denotes | miR-146 | |
T21079 | 8844-8848 | Protein | denotes | TRIF | |
T21078 | 10477-10482 | Protein | denotes | RANK, | |
T21077 | 8622-8640 | Protein | denotes | membrane receptors | |
T21076 | 10031-10036 | Protein | denotes | TRAF6 | |
T21075 | 9667-9672 | Protein | denotes | TRAF6 | |
T21074 | 8787-8792 | Protein | denotes | MyD88 | |
T21073 | 9658-9662 | Protein | denotes | RIP1 | |
T21072 | 8983-8988 | Protein | denotes | TRAFs | |
T21071 | 9534-9537 | Protein | denotes | A20 | |
T18867 | 31029-31120 | Gene_expression | denotes | Notably, both miR-146 and miR-155 are expressed at higher levels in RA synovial fibroblasts | |
T18866 | 30542-30568 | Protein_catabolism | denotes | of target mRNA degradation | |
T18865 | 31529-31639 | Gene_expression | denotes | cytokine-inducible expression of specific matrix metalloproteinases that mediate tissue destruction in RA [81] | |
T18864 | 31559-31639 | Regulation | denotes | of specific matrix metalloproteinases that mediate tissue destruction in RA [81] | |
T18863 | 31220-31311 | Positive_regulation | denotes | miR-146a is also overexpressed in CD4+ and IL-17-producing T cells from RA patients [84,85] | |
T18862 | 31220-31311 | Gene_expression | denotes | miR-146a is also overexpressed in CD4+ and IL-17-producing T cells from RA patients [84,85] | |
T18861 | 31450-31496 | Gene_expression | denotes | miR-155 overexpression in synovial fibroblasts | |
T18860 | 31450-31496 | Positive_regulation | denotes | miR-155 overexpression in synovial fibroblasts | |
T18859 | 32518-32579 | Gene_expression | denotes | to increased secretion of matrix metalloproteinase-1 and IL-6 | |
T18858 | 32518-32579 | Gene_expression | denotes | to increased secretion of matrix metalloproteinase-1 and IL-6 | |
T18857 | 31918-31944 | Positive_regulation | denotes | their increased expression | |
T18856 | 30528-30573 | Positive_regulation | denotes | the promotion of target mRNA degradation [77] | |
T18855 | 32518-32579 | Positive_regulation | denotes | to increased secretion of matrix metalloproteinase-1 and IL-6 | |
T18854 | 32518-32579 | Positive_regulation | denotes | to increased secretion of matrix metalloproteinase-1 and IL-6 | |
T18853 | 30502-30523 | Gene_expression | denotes | of protein expression | |
T18852 | 30736-30739 | Protein | denotes | TNF | |
T18851 | 31754-31761 | Protein | denotes | miR-155 | |
T18850 | 32575-32579 | Protein | denotes | IL-6 | |
T18849 | 32452-32454 | Protein | denotes | RA | |
T18848 | 32358-32367 | Protein | denotes | chemokine | |
T18847 | 30575-30585 | Protein | denotes | miR-146a/b | |
T18846 | 32599-32601 | Protein | denotes | RA | |
T18845 | 31220-31228 | Protein | denotes | miR-146a | |
T18844 | 31292-31294 | Protein | denotes | RA | |
T18843 | 31632-31639 | Protein | denotes | RA [81] | |
T18842 | 32140-32147 | Entity | denotes | miR-146 | |
T18841 | 30786-30801 | Protein | denotes | NF-κB-dependent | |
T18840 | 32434-32446 | Entity | denotes | synoviocytes | |
T18839 | 31559-31639 | Protein | denotes | of specific matrix metalloproteinases that mediate tissue destruction in RA [81] | |
T18838 | 30783-30806 | Protein | denotes | an NF-κB-dependent gene | |
T18837 | 32638-32644 | Protein | denotes | miR-16 | |
T18836 | 30812-30848 | Entity | denotes | the NF-κB signalling molecules IRAK1 | |
T18835 | 31450-31457 | Protein | denotes | miR-155 | |
T18834 | 30975-31010 | Protein | denotes | the NF-κB signalling molecules IKKε | |
T18833 | 31055-31062 | Protein | denotes | miR-155 | |
T18832 | 30656-30661 | Protein | denotes | NF-κB | |
T18831 | 30878-30918 | Protein | denotes | target genes of miR-146a [78] (Figure 1) | |
T18830 | 30975-31010 | Entity | denotes | the NF-κB signalling molecules IKKε | |
T18829 | 30853-30858 | Protein | denotes | TRAF6 | |
T18828 | 30894-30907 | Protein | denotes | miR-146a [78] | |
T18827 | 31476-31496 | Entity | denotes | synovial fibroblasts | |
T18826 | 31651-31658 | Protein | denotes | miR-155 | |
T18825 | 31254-31311 | Entity | denotes | CD4+ and IL-17-producing T cells from RA patients [84,85] | |
T18824 | 31742-31749 | Entity | denotes | miR-146 | |
T18823 | 32659-32666 | Protein | denotes | miR-223 | |
T18822 | 30959-30970 | Protein | denotes | transcripts | |
T18821 | 30697-30734 | Protein | denotes | by inflammatory stimuli such as IL-1β | |
T18820 | 32324-32332 | Protein | denotes | miR-124a | |
T18819 | 32716-32718 | Protein | denotes | RA | |
T18818 | 30979-30984 | Protein | denotes | NF-κB | |
T18817 | 32544-32570 | Protein | denotes | matrix metalloproteinase-1 | |
T18816 | 30575-30585 | Protein | denotes | miR-146a/b | |
T18815 | 30812-30848 | Protein | denotes | the NF-κB signalling molecules IRAK1 | |
T18814 | 31380-31384 | Protein | denotes | gene | |
T18813 | 30931-30938 | Protein | denotes | miR-155 | |
T18812 | 31097-31120 | Entity | denotes | RA synovial fibroblasts | |
T18811 | 30552-30556 | Protein | denotes | mRNA | |
T18810 | 30584-30585 | Protein | denotes | b | |
T18809 | 31364-31372 | Protein | denotes | miR-146a | |
T18808 | 32268-32280 | Protein | denotes | RA pathology | |
T18807 | 31828-31830 | Protein | denotes | RA | |
T18806 | 31043-31050 | Entity | denotes | miR-146 | |
T18805 | 31097-31099 | Protein | denotes | RA | |
T18804 | 30324-30327 | Protein | denotes | RNA | |
T18803 | 32646-32653 | Protein | denotes | miR-132 | |
T18802 | 31948-31950 | Protein | denotes | RA | |
T18801 | 30590-30597 | Protein | denotes | miR-155 | |
T18800 | 32611-32627 | Entity | denotes | fibroblasts [90] | |
T18799 | 32354-32402 | Protein | denotes | the chemokine monocyte chemoattractant protein 1 | |
T18798 | 32500-32507 | Protein | denotes | miR-203 | |
T18797 | 30311-30347 | Entity | denotes | of noncoding RNA molecules essential | |
T18796 | 30771-30779 | Protein | denotes | miR-146a | |
T18795 | 31015-31019 | Protein | denotes | RIP1 | |
T18794 | 30816-30821 | Protein | denotes | NF-κB | |
T18793 | 32226-32241 | Protein | denotes | NF-κB-dependent | |
T18792 | 30463-30573 | Protein | denotes | target mRNAs leading to the repression of protein expression and the promotion of target mRNA degradation [77] | |
T18791 | 31164-31218 | Entity | denotes | peripheral blood mononuclear cells of RA patients [83] | |
T18790 | 32152-32160 | Protein | denotes | miR-155, | |
T18789 | 31733-31735 | Protein | denotes | RA | |
T18788 | 31426-31428 | Protein | denotes | RA | |
T18787 | 31202-31204 | Protein | denotes | RA | |
T18786 | 30505-30512 | Protein | denotes | protein | |
T19203 | 32972-32988 | Positive_regulation | denotes | NF-κB activation | |
T19202 | 32827-32832 | Protein | denotes | NF-κB | |
T19201 | 33145-33165 | Protein | denotes | of the NF-κB pathway | |
T19200 | 33334-33365 | Protein | denotes | the multiple mRNAs they target, | |
T19199 | 33618-33650 | Protein | denotes | inflammatory diseases such as RA | |
T19198 | 32972-32977 | Protein | denotes | NF-κB | |
T19197 | 33514-33530 | Protein | denotes | NF-κB signalling | |
T19196 | 32918-32920 | Protein | denotes | RA | |
T17221 | 29528-29533 | Protein | denotes | TRAF1 | |
T17220 | 29615-29619 | Protein | denotes | TRAF | |
T17219 | 29595-29600 | Protein | denotes | TRAF1 | |
T17218 | 30057-30062 | Protein | denotes | TRAF1 | |
T17217 | 29544-29561 | Protein | denotes | NF- κB activation | |
T17216 | 29708-29713 | Protein | denotes | TRAF1 | |
T17264 | 29639-29691 | Binding | denotes | binding to the receptor or other signalling proteins | |
T17263 | 29299-29328 | Positive_regulation | denotes | CD40-induced NF-κB activation | |
T17262 | 29732-29769 | Binding | denotes | with which it can physically interact | true |
T17261 | 29092-29120 | Positive_regulation | denotes | TNF-induced NF-κB activation | |
T17260 | 29720-29731 | Binding | denotes | recruit A20 | |
T17259 | 29015-29034 | Gene_expression | denotes | Expression of TRAF1 | |
T17258 | 29048-29120 | Negative_regulation | denotes | by TNF and overexpression of TRAF1 inhibits TNF-induced NF-κB activation | |
T17257 | 29728-29731 | Protein | denotes | A20 | |
T17256 | 30203-30215 | Protein | denotes | with RA [76] | |
T17255 | 30006-30008 | Protein | denotes | RA | |
T17254 | 28862-28867 | Protein | denotes | TRAF1 | |
T17253 | 29961-29983 | Protein | denotes | complement component 5 | |
T17252 | 29092-29103 | Protein | denotes | TNF-induced | |
T17251 | 28935-28963 | Protein | denotes | certain TNF family receptors | |
T17250 | 28943-28946 | Protein | denotes | TNF | |
T17249 | 29955-29983 | Protein | denotes | TRAF1-complement component 5 | |
T17248 | 29312-29317 | Protein | denotes | NF-κB | |
T17247 | 28757-28777 | Entity | denotes | a RING finger domain | |
T17246 | 28915-28931 | Protein | denotes | NF-κB signalling | |
T17245 | 28688-28693 | Protein | denotes | TRAF1 | |
T17244 | 29077-29082 | Protein | denotes | TRAF1 | |
T17243 | 29170-29202 | Protein | denotes | TNF, with enhanced proliferation | |
T17242 | 29122-29145 | Entity | denotes | TRAF1-deficient T cells | |
T17241 | 30190-30195 | Protein | denotes | TRAF1 | |
T17240 | 29955-29983 | Protein | denotes | TRAF1-complement component 5 | |
T17239 | 29251-29256 | Protein | denotes | TRAF1 | |
T17238 | 28720-28724 | Protein | denotes | TRAF | |
T17237 | 29889-29891 | Protein | denotes | RA | |
T17236 | 28798-28823 | Protein | denotes | ubiquitin ligase activity | |
T17235 | 29104-29109 | Protein | denotes | NF-κB | |
T17234 | 29426-29441 | Protein | denotes | TRAF2-dependent | |
T17233 | 29650-29662 | Protein | denotes | the receptor | |
T17232 | 29336-29361 | Entity | denotes | deficient dendritic cells | |
T17231 | 29051-29054 | Protein | denotes | TNF | |
T17230 | 29299-29311 | Protein | denotes | CD40-induced | |
T17229 | 28798-28807 | Protein | denotes | ubiquitin | |
T17228 | 29330-29335 | Protein | denotes | TRAF1 | |
T17227 | 28713-28739 | Protein | denotes | of the TRAF protein family | |
T17226 | 28655-28687 | Protein | denotes | TNF receptor-associated factor 1 | |
T17225 | 29218-29249 | Protein | denotes | of the NF-κB signalling pathway | |
T17224 | 29492-29503 | Entity | denotes | these cells | |
T17223 | 29026-29034 | Protein | denotes | of TRAF1 | |
T17222 | 29666-29691 | Protein | denotes | other signalling proteins | |
T16246 | 28019-28040 | Gene_expression | denotes | SIGIRR overexpression | |
T16245 | 28019-28040 | Positive_regulation | denotes | SIGIRR overexpression | |
T16244 | 28009-28138 | Negative_regulation | denotes | Recently, SIGIRR overexpression was shown to inhibit the spontaneous release of inflammatory cytokines by human RA synovial cells | |
T16243 | 28009-28138 | Negative_regulation | denotes | Recently, SIGIRR overexpression was shown to inhibit the spontaneous release of inflammatory cytokines by human RA synovial cells | |
T16242 | 28062-28138 | Regulation | denotes | the spontaneous release of inflammatory cytokines by human RA synovial cells | |
T16241 | 28376-28457 | Gene_expression | denotes | to compare the expression of SIGIRR in RA patients with its expression in control | |
T16240 | 27609-27687 | Binding | denotes | direct interaction with these receptors, MyD88, IRAK1 or TRAF6 [67] (Figure 1) | |
T16239 | 27854-27882 | Negative_regulation | denotes | a very restricted expression | |
T16238 | 28121-28123 | Protein | denotes | RA | |
T16237 | 27633-27648 | Protein | denotes | these receptors | |
T16236 | 28019-28025 | Protein | denotes | SIGIRR | |
T16235 | 27566-27571 | Protein | denotes | IL-1R | |
T16234 | 27464-27470 | Protein | denotes | TIR-8, | |
T16233 | 27657-27662 | Protein | denotes | IRAK1 | |
T16232 | 27813-27819 | Protein | denotes | SIGIRR | |
T16231 | 27494-27499 | Protein | denotes | IL-1R | |
T16230 | 28402-28411 | Protein | denotes | of SIGIRR | |
T16229 | 27343-27357 | Protein | denotes | immunoglobulin | |
T16228 | 27843-27849 | Protein | denotes | SIGIRR | |
T16227 | 27553-27579 | Entity | denotes | inhibitor of IL-1R and TLR | |
T16226 | 28307-28323 | Entity | denotes | collagen-induced | |
T16225 | 27358-27362 | Protein | denotes | IL-1 | |
T16224 | 27388-27440 | Protein | denotes | Single-immunoglobulin IL-1 receptor-related (SIGIRR) | |
T16223 | 28415-28417 | Protein | denotes | RA | |
T16222 | 27943-27968 | Entity | denotes | immature dendritic cells, | |
T16221 | 27343-27387 | Protein | denotes | immunoglobulin IL-1 receptor-related protein | |
T16220 | 27980-27999 | Entity | denotes | mature macro-phages | |
T16219 | 28507-28516 | Protein | denotes | of SIGIRR | |
T16218 | 28212-28233 | Protein | denotes | SIGIRR-deficient mice | |
T16217 | 28086-28111 | Protein | denotes | of inflammatory cytokines | |
T16216 | 27717-27722 | Protein | denotes | IL-1R | |
T16215 | 28594-28600 | Protein | denotes | SIGIRR | |
T16214 | 27911-27927 | Entity | denotes | epithelial cells | |
T16213 | 27358-27379 | Protein | denotes | IL-1 receptor-related | |
T16212 | 28112-28138 | Entity | denotes | by human RA synovial cells | |
T16211 | 27666-27676 | Protein | denotes | TRAF6 [67] | |
T16210 | 28650-28652 | Protein | denotes | RA | |
T16209 | 27823-27825 | Protein | denotes | RA | |
T16208 | 27782-27789 | Protein | denotes | RA [68] | |
T16207 | 28535-28537 | Protein | denotes | RA | |
T16206 | 27433-27439 | Protein | denotes | SIGIRR | |
T16205 | 27929-27938 | Entity | denotes | monocytes | |
T16204 | 28168-28174 | Protein | denotes | SIGIRR | |
T16203 | 28269-28284 | Entity | denotes | zymosan-induced | |
T16202 | 27650-27655 | Protein | denotes | MyD88 | |
T16201 | 27388-27448 | Protein | denotes | Single-immunoglobulin IL-1 receptor-related (SIGIRR) protein | |
T15367 | 26743-26762 | Ubiquitination | denotes | ubiquitinated TRAF6 | |
T15366 | 25638-25664 | Positive_regulation | denotes | NF-κB signalling initiated | |
T15365 | 26275-26384 | Regulation | denotes | Interestingly, CYLD has been shown to negatively regulate RANK signalling and osteoclastogenesis in mice [65] | |
T15364 | 25683-25699 | Localization | denotes | T-cell receptor | |
T15363 | 25683-25710 | Positive_regulation | denotes | T-cell receptor stimulation | |
T15362 | 26855-26901 | Regulation | denotes | by the CYLD-mediated deubiquitination of TRAF6 | |
T15361 | 26630-26645 | Gene_expression | denotes | CYLD expression | |
T15360 | 25933-25980 | Regulation | denotes | A20 as well as CYLD to control NF-κB activation | |
T15359 | 25964-25980 | Positive_regulation | denotes | NF-κB activation | |
T15358 | 25612-25710 | Regulation | denotes | that negatively regulates NF-κB signalling initiated by TNFR, RANK and T-cell receptor stimulation | |
T15357 | 26690-26703 | Protein | denotes | RANKL-induced | |
T15356 | 27106-27119 | Protein | denotes | CYLD-mediated | |
T15355 | 26143-26147 | Protein | denotes | CYLD | |
T15354 | 25605-25710 | Protein | denotes | enzyme that negatively regulates NF-κB signalling initiated by TNFR, RANK and T-cell receptor stimulation | |
T15353 | 26990-26996 | Protein | denotes | of p62 | |
T15352 | 26499-26534 | Entity | denotes | Osteoclast precursors of these mice | |
T15351 | 27308-27333 | Protein | denotes | bone disorders such as RA | |
T15350 | 25385-25389 | Protein | denotes | CYLD | |
T15349 | 25964-25969 | Protein | denotes | NF-κB | |
T15348 | 26071-26083 | Protein | denotes | this protein | |
T15347 | 25807-25811 | Protein | denotes | NEMO | |
T15346 | 27244-27248 | Protein | denotes | CYLD | |
T15345 | 26333-26384 | Protein | denotes | RANK signalling and osteoclastogenesis in mice [65] | |
T15344 | 25881-25887 | Protein | denotes | by A20 | |
T15343 | 26290-26294 | Protein | denotes | CYLD | |
T15342 | 25985-25988 | Protein | denotes | A20 | |
T15341 | 26824-26838 | Protein | denotes | sequestosome 1 | |
T15340 | 25668-25672 | Protein | denotes | TNFR | |
T15339 | 25683-25689 | Entity | denotes | T-cell | |
T15338 | 25843-25847 | Protein | denotes | TAK1 | |
T15337 | 26417-26424 | Protein | denotes | of CYLD | |
T15336 | 26010-26025 | Entity | denotes | many cell types | |
T15335 | 25238-25261 | Protein | denotes | Cylindromatosis protein | |
T15334 | 26893-26901 | Protein | denotes | of TRAF6 | |
T15333 | 25262-25284 | Protein | denotes | Cylindromatosis (CYLD) | |
T15332 | 25745-25796 | Protein | denotes | deubiquitina-ting several NF-κB signalling proteins | |
T15331 | 25827-25832 | Protein | denotes | TRAF7 | |
T15330 | 26743-26762 | Protein | denotes | ubiquitinated TRAF6 | |
T15329 | 25933-25952 | Protein | denotes | A20 as well as CYLD | |
T15328 | 25813-25818 | Protein | denotes | TRAF2 | |
T15327 | 27135-27164 | Protein | denotes | RANK-induced NF-κB signalling | |
T15326 | 26610-26628 | Entity | denotes | larger osteoclasts | |
T15325 | 26789-26808 | Protein | denotes | adaptor protein p62 | |
T15324 | 25279-25283 | Protein | denotes | CYLD | |
T15323 | 26386-26424 | Protein | denotes | Mice with a genetic deficiency of CYLD | |
T15322 | 27135-27147 | Protein | denotes | RANK-induced | |
T15321 | 25238-25253 | Protein | denotes | Cylindromatosis | |
T15320 | 26789-26808 | Protein | denotes | adaptor protein p62 | |
T15319 | 26249-26268 | Entity | denotes | cell-type dependent | |
T15318 | 26767-26788 | Protein | denotes | the ubiquitin-binding | |
T15317 | 25745-25796 | Protein | denotes | deubiquitina-ting several NF-κB signalling proteins | |
T15316 | 25948-25952 | Protein | denotes | CYLD | |
T15315 | 25674-25678 | Protein | denotes | RANK | |
T15314 | 26630-26634 | Protein | denotes | CYLD | |
T15313 | 26114-26133 | Protein | denotes | of NF-κB signalling | |
T15312 | 26862-26875 | Protein | denotes | CYLD-mediated | |
T15311 | 26559-26564 | Protein | denotes | RANKL | |
T15310 | 25834-25838 | Protein | denotes | RIP1 | |
T15309 | 25820-25825 | Protein | denotes | TRAF6 | |
T15308 | 25262-25292 | Protein | denotes | Cylindromatosis (CYLD) protein | |
T15307 | 25683-25698 | Protein | denotes | T-cell receptor | |
T15306 | 25578-25582 | Protein | denotes | CYLD | |
T15305 | 25918-25926 | Entity | denotes | the cell | |
T15304 | 25638-25643 | Protein | denotes | NF-κB | |
T15303 | 26375-26384 | Protein | denotes | mice [65] | |
T15302 | 25351-25383 | Protein | denotes | in familial cylindromatosis [63] | |
T13959 | 23009-23033 | Binding | denotes | A20 interacting proteins | |
T13958 | 23436-23455 | Positive_regulation | denotes | of NF-κB activation | |
T13957 | 23696-23736 | Gene_expression | denotes | Functional ABIN-3 is expressed in humans | |
T13956 | 24964-24987 | Gene_expression | denotes | autoantibody production | |
T13955 | 24475-24540 | Gene_expression | denotes | on the expression of the NF-κB inhibitory proteins ABIN-3 and A20 | |
T13954 | 24076-24116 | Localization | denotes | TNF-induced genes in human synoviocytes, | |
T13953 | 24076-24116 | Gene_expression | denotes | TNF-induced genes in human synoviocytes, | |
T13952 | 24076-24116 | Positive_regulation | denotes | TNF-induced genes in human synoviocytes, | |
T13951 | 22986-23095 | Gene_expression | denotes | ubiquitously expressed A20 interacting proteins and were shown to inhibit NF-κB activation by TNF and several | |
T13950 | 24552-24662 | Negative_regulation | denotes | this protective effect of the ITAM was strongly suppressed in inflammatory arthritis synovial macrophages [60] | |
T13949 | 25228-25235 | Protein | denotes | with RA | |
T13948 | 22939-22966 | Protein | denotes | TNIP-1, TNIP-2, and TNIP-3) | |
T13947 | 23387-23391 | Protein | denotes | ABIN | |
T13946 | 24431-24435 | Entity | denotes | ITAM | |
T13945 | 23915-23936 | Protein | denotes | ABIN-1 deficient mice | |
T13944 | 23329-23344 | Protein | denotes | NF-κB dependent | |
T13943 | 24048-24054 | Protein | denotes | ABIN-1 | |
T13942 | 23009-23033 | Protein | denotes | A20 interacting proteins | |
T13941 | 24217-24224 | Protein | denotes | ABIN-1, | |
T13940 | 22892-22897 | Protein | denotes | NF-κB | |
T13939 | 24380-24436 | Entity | denotes | by immunoreceptor tyrosine-based activation motif (ITAM) | |
T13938 | 25060-25069 | Entity | denotes | rituximab | |
T13937 | 24280-24299 | Protein | denotes | of NF-κB signalling | |
T13936 | 24493-24540 | Protein | denotes | of the NF-κB inhibitory proteins ABIN-3 and A20 | |
T13935 | 23060-23065 | Protein | denotes | NF-κB | |
T13934 | 23080-23083 | Protein | denotes | TNF | |
T13933 | 23883-23894 | Protein | denotes | TNF-induced | |
T13932 | 24076-24116 | Protein | denotes | TNF-induced genes in human synoviocytes, | |
T13931 | 24165-24167 | Protein | denotes | RA | |
T13930 | 23962-23975 | Protein | denotes | TNF-dependent | |
T13929 | 23379-23399 | Entity | denotes | the A20/ABIN complex | |
T13928 | 22898-22904 | Protein | denotes | ABIN-1 | |
T13927 | 22959-22965 | Protein | denotes | TNIP-3 | |
T13926 | 24239-24331 | Protein | denotes | A20, in the negative feedback regulation of NF-κB signalling and the pathogenesis of RA [59] | |
T13925 | 23292-23295 | Protein | denotes | A20 | |
T13924 | 23439-23444 | Protein | denotes | NF-κB | |
T13923 | 23009-23033 | Protein | denotes | A20 interacting proteins | |
T13922 | 23236-23239 | Protein | denotes | A20 | |
T13921 | 23297-23303 | Protein | denotes | ABIN-1 | |
T13920 | 22906-22912 | Protein | denotes | ABIN-2 | |
T13919 | 23243-23279 | Entity | denotes | polyubiquitinated substrates [43,44] | |
T13918 | 24537-24540 | Protein | denotes | A20 | |
T13917 | 24614-24662 | Entity | denotes | inflammatory arthritis synovial macrophages [60] | |
T13916 | 23379-23399 | Protein | denotes | the A20/ABIN complex | |
T13915 | 24679-24699 | Protein | denotes | ABIN-1 polymorphisms | |
T13914 | 24575-24586 | Entity | denotes | of the ITAM | |
T13913 | 23580-23585 | Protein | denotes | NF-κB | |
T13912 | 23742-23746 | Protein | denotes | mice | |
T13911 | 24097-24116 | Entity | denotes | human synoviocytes, | |
T13910 | 24136-24147 | Protein | denotes | ABIN-1 mRNA | |
T13909 | 23516-23537 | Protein | denotes | ABIN-2-deficient mice | |
T13908 | 24436-24454 | Protein | denotes | -coupled receptors | |
T13907 | 24526-24532 | Protein | denotes | ABIN-3 | |
T13906 | 23915-23921 | Protein | denotes | ABIN-1 | |
T13905 | 22947-22954 | Protein | denotes | TNIP-2, | |
T13904 | 24964-24976 | Protein | denotes | autoantibody | |
T13903 | 23308-23314 | Protein | denotes | ABIN-3 | |
T13902 | 23696-23713 | Protein | denotes | Functional ABIN-3 | |
T13901 | 24136-24142 | Protein | denotes | ABIN-1 | |
T13900 | 22866-22897 | Entity | denotes | A20-binding inhibitors of NF-κB | |
T13899 | 23641-23646 | Protein | denotes | NF-κB | |
T13898 | 24076-24087 | Protein | denotes | TNF-induced | |
T13897 | 24324-24326 | Protein | denotes | RA | |
T13896 | 24500-24505 | Protein | denotes | NF-κB | |
T13895 | 23810-23839 | Entity | denotes | ubiquitin-binding domain [57] | |
T13894 | 25042-25048 | Entity | denotes | B-cell | |
T13893 | 23762-23789 | Protein | denotes | truncated and inactive form | |
T13892 | 22917-22923 | Protein | denotes | ABIN-3 | |
T13891 | 24854-24856 | Protein | denotes | RA | |
T13890 | 24005-24046 | Entity | denotes | Using oligonucleotide microarray analysis | |
T13889 | 23853-23859 | Protein | denotes | ABIN-1 | |
T12419 | 18038-18069 | Regulation | denotes | NF-κB-dependent gene expression | |
T12418 | 19684-19747 | Localization | denotes | a major antiapoptotic protein in the intestinal epithelium [47] | |
T12417 | 18734-18809 | Regulation | denotes | The association of A20 with its targets requires specific ubiquitin-binding | |
T12416 | 21162-21180 | Gene_expression | denotes | A20 overexpression | |
T12415 | 21162-21180 | Positive_regulation | denotes | A20 overexpression | |
T12414 | 20106-20120 | Gene_expression | denotes | A20 expression | |
T12413 | 20141-20171 | Gene_expression | denotes | by NF-κB [50], implicating A20 | |
T12412 | 21783-21820 | Binding | denotes | a clear association between mutations | |
T12411 | 22545-22572 | Negative_regulation | denotes | repressed A20 transcription | |
T12410 | 20499-20513 | Gene_expression | denotes | A20 expression | |
T12409 | 18783-18809 | Binding | denotes | specific ubiquitin-binding | |
T12408 | 18934-18963 | Negative_regulation | denotes | suppressing NF-κB activation, | |
T12407 | 21451-21566 | Localization | denotes | that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells | |
T12406 | 22534-22572 | Transcription | denotes | could show repressed A20 transcription | |
T12405 | 18734-18756 | Binding | denotes | The association of A20 | |
T12404 | 18946-18962 | Positive_regulation | denotes | NF-κB activation | |
T12403 | 20567-20572 | Protein | denotes | NF-κB | |
T12402 | 22507-22519 | Entity | denotes | A20 promoter | |
T12401 | 21162-21165 | Protein | denotes | A20 | |
T12400 | 22290-22292 | Protein | denotes | RA | |
T12399 | 20618-20622 | Protein | denotes | IL-6 | |
T12398 | 22832-22834 | Protein | denotes | RA | |
T12397 | 22359-22361 | Protein | denotes | RA | |
T12396 | 20397-20413 | Entity | denotes | collagen-induced | |
T12395 | 18337-18373 | Protein | denotes | specific NF-κB signalling molecules, | |
T12394 | 21982-21985 | Protein | denotes | A20 | |
T12393 | 21944-21950 | Protein | denotes | a gene | |
T12392 | 18810-18912 | Protein | denotes | adaptor proteins, including A20-binding inhibitor of NF-κB (ABIN) 1 and Tax1-binding protein 1 [43-46] | |
T12391 | 17972-17979 | Protein | denotes | TNFAIP3 | |
T12390 | 18882-18912 | Protein | denotes | Tax1-binding protein 1 [43-46] | |
T12389 | 20861-20864 | Protein | denotes | TNF | |
T12388 | 19872-19879 | Entity | denotes | B cells | |
T12387 | 21531-21546 | Entity | denotes | dendritic cells | |
T12386 | 18302-18307 | Protein | denotes | NF-κB | |
T12385 | 22507-22510 | Protein | denotes | A20 | |
T12384 | 18388-18392 | Protein | denotes | RIP2 | |
T12383 | 20698-20706 | Protein | denotes | that A20 | |
T12382 | 18577-18583 | Protein | denotes | Ubc5hc | |
T12381 | 18382-18386 | Protein | denotes | RIP1 | |
T12380 | 19606-19639 | Entity | denotes | their intestinal epithelial cells | |
T12379 | 20208-20216 | Protein | denotes | of NF-κB | |
T12378 | 18628-18635 | Protein | denotes | cIAP1/2 | |
T12377 | 19250-19278 | Entity | denotes | the potent anti-inflammatory | |
T12376 | 19853-19858 | Protein | denotes | NF-κB | |
T12375 | 19360-19372 | Protein | denotes | TNF-mediated | |
T12374 | 20606-20610 | Protein | denotes | TNF, | |
T12373 | 22220-22222 | Protein | denotes | RA | |
T12372 | 19311-19314 | Protein | denotes | A20 | |
T12371 | 20996-20999 | Protein | denotes | TNF | |
T12370 | 18618-18623 | Protein | denotes | TRAF2 | |
T12369 | 18146-18154 | Entity | denotes | antigens | |
T12368 | 18533-18584 | Protein | denotes | E2 ubiquitin conjugating enzymes (Ubc13 and Ubc5hc) | |
T12367 | 18589-18636 | Protein | denotes | E3 ubiquitin ligases (TRAF6, TRAF2 and cIAP1/2) | |
T12366 | 19684-19747 | Protein | denotes | a major antiapoptotic protein in the intestinal epithelium [47] | |
T12365 | 18187-18225 | Protein | denotes | the nucleotide-binding oligomerisation | |
T12364 | 20078-20089 | Entity | denotes | lymphocytes | |
T12363 | 18226-18254 | Protein | denotes | domain-containing 2 receptor | |
T12362 | 18964-18967 | Protein | denotes | A20 | |
T12361 | 18137-18141 | Protein | denotes | IL-1 | |
T12360 | 19062-19065 | Protein | denotes | A20 | |
T12359 | 19904-19910 | Entity | denotes | B-cell | |
T12358 | 18038-18053 | Protein | denotes | NF-κB-dependent | |
T12357 | 17984-18011 | Protein | denotes | a ubiquitin-editing protein | |
T12356 | 19798-19801 | Protein | denotes | A20 | |
T12355 | 19780-19789 | Protein | denotes | that mice | |
T12354 | 22116-22119 | Protein | denotes | A20 | |
T12353 | 21989-22005 | Protein | denotes | its nearest gene | |
T12352 | 20168-20171 | Protein | denotes | A20 | |
T12351 | 18589-18636 | Protein | denotes | E3 ubiquitin ligases (TRAF6, TRAF2 and cIAP1/2) | |
T12350 | 18634-18635 | Protein | denotes | 2 | |
T12349 | 22327-22330 | Protein | denotes | A20 | |
T12348 | 21607-21610 | Protein | denotes | A20 | |
T12347 | 20048-20059 | Entity | denotes | fibroblasts | |
T12346 | 18750-18756 | Protein | denotes | of A20 | |
T12345 | 21215-21239 | Entity | denotes | of activated osteoclasts | |
T12344 | 19126-19144 | Protein | denotes | A20-deficient mice | |
T12343 | 19407-19431 | Protein | denotes | an antiapoptotic protein | |
T12342 | 21518-21529 | Entity | denotes | macrophages | |
T12341 | 17953-17956 | Protein | denotes | A20 | |
T12340 | 19021-19036 | Entity | denotes | some cell types | |
T12339 | 17941-17944 | Protein | denotes | A20 | |
T12338 | 20036-20038 | Protein | denotes | RA | |
T12337 | 18976-19008 | Entity | denotes | a strong inhibitor of apoptosis, | |
T12336 | 19315-19330 | Entity | denotes | deficient cells | |
T12335 | 18946-18951 | Protein | denotes | NF-κB | |
T12334 | 19929-19932 | Protein | denotes | A20 | |
T12333 | 21446-21450 | Protein | denotes | mice | |
T12332 | 20869-20874 | Protein | denotes | IL-1β | |
T12331 | 18628-18635 | Protein | denotes | cIAP1/2 | |
T12330 | 21451-21566 | Protein | denotes | that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells | |
T12329 | 20793-20809 | Protein | denotes | NF-κB activation | |
T12328 | 18567-18572 | Protein | denotes | Ubc13 | |
T12327 | 22029-22032 | Protein | denotes | A20 | |
T12326 | 18792-18801 | Protein | denotes | ubiquitin | |
T12325 | 21468-21516 | Entity | denotes | specific cell types such as synovial fibroblasts | |
T12324 | 20738-20754 | Entity | denotes | collagen-induced | |
T12323 | 20144-20155 | Protein | denotes | NF-κB [50], | |
T12322 | 20765-20769 | Protein | denotes | mice | |
T12321 | 21883-21890 | Protein | denotes | RA [52] | |
T12320 | 22246-22249 | Protein | denotes | A20 | |
T12319 | 22474-22490 | Entity | denotes | of RA-associated | |
T12318 | 18337-18373 | Entity | denotes | specific NF-κB signalling molecules, | |
T12317 | 20639-20675 | Protein | denotes | monocyte chemo-attractant protein 1, | |
T12316 | 20499-20502 | Protein | denotes | A20 | |
T12315 | 22183-22222 | Protein | denotes | the primary inflammatory cytokine in RA | |
T12314 | 21559-21566 | Entity | denotes | T cells | |
T12313 | 19452-19461 | Protein | denotes | that mice | |
T12312 | 21468-21495 | Entity | denotes | specific cell types such as | |
T12311 | 19677-19680 | Protein | denotes | A20 | |
T12310 | 20061-20073 | Entity | denotes | synoviocytes | |
T12309 | 21257-21260 | Protein | denotes | A20 | |
T12308 | 19805-19812 | Entity | denotes | B cells | |
T12307 | 19643-19654 | Protein | denotes | TNF-induced | |
T12306 | 18688-18694 | Protein | denotes | by A20 | |
T12305 | 21004-21032 | Protein | denotes | IL-1β in A20-transduced mice | |
T12304 | 19483-19486 | Protein | denotes | A20 | |
T12303 | 19490-19517 | Entity | denotes | intestinal epithelial cells | |
T12302 | 19965-20039 | Entity | denotes | several cell types that play important roles in the pathophysiology of RA, | |
T12301 | 18711-18716 | Protein | denotes | NF-κB | |
T12300 | 18611-18616 | Protein | denotes | TRAF6 | |
T12299 | 20606-20623 | Protein | denotes | TNF, IL-1β, IL-6, | |
T12298 | 21824-21831 | Protein | denotes | the A20 | |
T12297 | 18394-18399 | Protein | denotes | TRAF6 | |
T12296 | 18275-18278 | Protein | denotes | A20 | |
T12295 | 18132-18135 | Protein | denotes | TNF | |
T12294 | 20962-20965 | Protein | denotes | RA, | |
T12293 | 19288-19309 | Entity | denotes | of this molecule [46] | |
T12292 | 22151-22162 | Protein | denotes | TNF-induced | |
T12291 | 22084-22087 | Entity | denotes | DNA | |
T12290 | 21841-21860 | Entity | denotes | the 6q23 chromosome | |
T12289 | 20106-20109 | Protein | denotes | A20 | |
T12288 | 22791-22794 | Protein | denotes | A20 | |
T12287 | 21013-21032 | Protein | denotes | A20-transduced mice | |
T12286 | 21548-21555 | Entity | denotes | B cells | |
T12285 | 18838-18877 | Protein | denotes | A20-binding inhibitor of NF-κB (ABIN) 1 | |
T12284 | 20459-20473 | Entity | denotes | a prophylactic | |
T12283 | 22555-22558 | Protein | denotes | A20 | |
T12282 | 22176-22179 | Protein | denotes | TNF | |
T12281 | 21323-21344 | Entity | denotes | the osteoclast number | |
T12280 | 18404-18410 | Protein | denotes | MALT1, | |
T12279 | 20632-20686 | Protein | denotes | RANKL, monocyte chemo-attractant protein 1, and IL-17, | |
T12278 | 17941-17952 | Protein | denotes | A20 protein | |
T12277 | 20268-20285 | Protein | denotes | an A20-expressing | |
T12276 | 20680-20685 | Protein | denotes | IL-17 | |
T9339 | 17705-17741 | Regulation | denotes | regulation of the noncanonical NF-κB | |
T9338 | 17580-17606 | Phosphorylation | denotes | phosphorylating STAT1 [35] | |
T9337 | 17457-17473 | Protein_catabolism | denotes | IκBα degradation | |
T9336 | 15968-15984 | Positive_regulation | denotes | NF-κB activation | |
T9335 | 17428-17452 | Positive_regulation | denotes | enhanced IKK2 activation | |
T9334 | 17508-17529 | Negative_regulation | denotes | inhibit nuclear NF-κB | |
T9333 | 17333-17357 | Gene_expression | denotes | expressing inactive IKK1 | |
T9332 | 16234-16261 | Positive_regulation | denotes | persistent NF-κB activation | |
T9331 | 16605-16625 | Regulation | denotes | the control of NF-κB | |
T9330 | 17608-17704 | Phosphorylation | denotes | Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback | |
T9329 | 17428-17452 | Positive_regulation | denotes | enhanced IKK2 activation | |
T9328 | 17363-17383 | Positive_regulation | denotes | increased production | |
T9327 | 16226-16261 | Negative_regulation | denotes | prevent persistent NF-κB activation | |
T9326 | 16402-16461 | Protein | denotes | inhibitory proteins that downregulate NF-κB signalling [32] | |
T9325 | 16570-16575 | Protein | denotes | NF-κB | |
T9324 | 17297-17301 | Protein | denotes | IKK1 | |
T9323 | 16847-16862 | Protein | denotes | NF-κB-dependent | |
T9322 | 17823-17938 | Protein | denotes | both canonical and noncanonical NF-κB pathways with possible implications for chronic inflammatory diseases like RA | |
T9321 | 17162-17173 | Protein | denotes | this kinase | |
T9320 | 17312-17316 | Protein | denotes | mice | |
T9319 | 17344-17357 | Protein | denotes | inactive IKK1 | |
T9318 | 17069-17073 | Protein | denotes | IKK1 | |
T9317 | 17776-17785 | Protein | denotes | that IKK1 | |
T9316 | 17596-17606 | Protein | denotes | STAT1 [35] | |
T9315 | 17936-17938 | Protein | denotes | RA | |
T9314 | 16903-16909 | Protein | denotes | IRAK-M | |
T9313 | 17660-17664 | Protein | denotes | IKK1 | |
T9312 | 16778-16783 | Protein | denotes | of RA | |
T9311 | 17457-17461 | Protein | denotes | IκBα | |
T9310 | 16049-16077 | Protein | denotes | the NF-κB signalling pathway | |
T9309 | 16195-16200 | Protein | denotes | NF-κB | |
T9308 | 17680-17683 | Protein | denotes | NIK | |
T9307 | 16245-16250 | Protein | denotes | NF-κB | |
T9306 | 15968-15973 | Protein | denotes | NF-κB | |
T9305 | 17437-17441 | Protein | denotes | IKK2 | |
T9304 | 16339-16344 | Entity | denotes | cells | |
T9303 | 16617-16625 | Protein | denotes | of NF-κB | |
T9302 | 16895-16901 | Protein | denotes | MyD88s | |
T9301 | 17280-17301 | Entity | denotes | Macrophages from IKK1 | |
T9300 | 17716-17741 | Protein | denotes | of the noncanonical NF-κB | |
T9299 | 16082-16102 | Protein | denotes | the genes it induces | |
T9298 | 17480-17484 | Protein | denotes | IKK1 | |
T9297 | 16785-16886 | Protein | denotes | Several other proteins involved in the negative regulation of NF-κB-dependent inflammatory responses, | |
T9296 | 17098-17133 | Protein | denotes | of the non-canonical NF-κB pathway, | |
T9295 | 17020-17032 | Protein | denotes | RA pathology | |
T9294 | 17229-17278 | Protein | denotes | of both canonical and noncanonical NF-κB pathways | |
T9293 | 16915-16921 | Protein | denotes | TOLLIP | |
T9292 | 17516-17529 | Protein | denotes | nuclear NF-κB | |
T9291 | 16501-16512 | Protein | denotes | of proteins | |
T9290 | 16440-16461 | Protein | denotes | NF-κB signalling [32] | |
T8206 | 11994-12032 | Positive_regulation | denotes | TLR4 stimulation by lipopolysaccharide | |
T8205 | 15323-15346 | Binding | denotes | binding of their ligand | |
T8204 | 8077-8107 | Regulation | denotes | which mediates phosphorylation | |
T8203 | 13657-13689 | Protein_catabolism | denotes | for subsequent TRAF3 degradation | |
T8202 | 13777-13793 | Binding | denotes | NIK accumulation | |
T8201 | 15201-15316 | Regulation | denotes | lymphotoxin β receptor and RANK mediate the activation of both canonical and noncanonical NF-κB signalling pathways | |
T8200 | 15201-15316 | Regulation | denotes | lymphotoxin β receptor and RANK mediate the activation of both canonical and noncanonical NF-κB signalling pathways | |
T8199 | 11676-11710 | Positive_regulation | denotes | for TNF-activated NF-κB signalling | |
T8198 | 15747-15775 | Regulation | denotes | CD40-mediated JNK activation | |
T8197 | 15825-15845 | Positive_regulation | denotes | activation of NF-κB, | |
T8196 | 15635-15689 | Binding | denotes | associated with overlapping and distinct CD40-mediated | |
T8195 | 11572-11710 | Regulation | denotes | of a distinct E2/E3 enzyme complex that modifies NEMO with linear polyubiquitin chains and is essential for TNF-activated NF-κB signalling | |
T8194 | 11444-11530 | Binding | denotes | to recruit the IKK and TAK1 complex via the ubiquitin-binding proteins NEMO and TAB1/2 | |
T8193 | 13798-13818 | Phosphorylation | denotes | IKK1 phosphorylation | |
T8192 | 12209-12345 | Binding | denotes | to recruit myeloid differentiation primary response gene 88 (MyD88) and TIR domain-containing adaptor-inducing IFNβ (TRIF), respectively | |
T8191 | 7399-7435 | Positive_regulation | denotes | NF-κB transactivation in the nucleus | |
T8190 | 13567-13580 | Binding | denotes | recruiting it | |
T8189 | 12469-12497 | Ubiquitination | denotes | ubiquitination of TRAF6 [24] | |
T8188 | 13637-13689 | Regulation | denotes | which are essential for subsequent TRAF3 degradation | |
T8187 | 11308-11328 | Ubiquitination | denotes | RIP1 ubiquitination, | |
T8186 | 11167-11182 | Positive_regulation | denotes | TNF stimulation | |
T8185 | 15717-15731 | Localization | denotes | B cells TRAF6 | |
T8184 | 13607-13636 | Binding | denotes | to attract TRAF2 and cIAP1/2, | |
T8183 | 10795-10810 | Positive_regulation | denotes | TNF stimulation | |
T8182 | 12504-12567 | Binding | denotes | also recruits TRAF6 [25] and RIP1 [26] via a direct interaction | |
T8181 | 15780-15796 | Gene_expression | denotes | IL-6 production, | |
T8180 | 8497-8528 | Positive_regulation | denotes | canonical NF-κB activation [21] | |
T8179 | 11057-11151 | Binding | denotes | which in turn bind the E3 ubiquitin ligases cellular inhibitor of apoptosis (cIAP) 1 and cIAP2 | |
T8178 | 11057-11151 | Binding | denotes | which in turn bind the E3 ubiquitin ligases cellular inhibitor of apoptosis (cIAP) 1 and cIAP2 | |
T8177 | 15747-15775 | Positive_regulation | denotes | CD40-mediated JNK activation | |
T8176 | 7365-7435 | Positive_regulation | denotes | IκBξ and Bcl-3 instead potentiate NF-κB transactivation in the nucleus | |
T8175 | 7365-7435 | Positive_regulation | denotes | IκBξ and Bcl-3 instead potentiate NF-κB transactivation in the nucleus | |
T8174 | 7024-7114 | Binding | denotes | NF-κB proteins are sequestered in the cytoplasm as latent complexes by inhibitory proteins | |
T8173 | 13530-13597 | Negative_regulation | denotes | to remove TRAF3 from this complex by recruiting it to the receptor, | |
T8172 | 13712-13728 | Regulation | denotes | to releasing NIK | |
T8171 | 11184-11207 | Binding | denotes | TNF-receptor bound RIP1 | |
T8170 | 11498-11514 | Binding | denotes | binding proteins | |
T8169 | 10819-10895 | Binding | denotes | in the recruitment of TNF receptor-1-associated death domain (TRADD) protein | |
T8168 | 12041-12094 | Binding | denotes | the recruitment of Toll/IL-1 receptor adaptor protein | |
T8167 | 11076-11141 | Protein | denotes | the E3 ubiquitin ligases cellular inhibitor of apoptosis (cIAP) 1 | |
T8166 | 12863-12867 | Protein | denotes | p52, | |
T8165 | 8313-8317 | Protein | denotes | IKKβ | |
T8164 | 8412-8438 | Protein | denotes | Gene targeting experiments | |
T8163 | 8304-8308 | Protein | denotes | IKKα | |
T8162 | 7854-7903 | Protein | denotes | NF-κB signalling initiated by different receptors | |
T8161 | 12597-12601 | Protein | denotes | TAK1 | |
T8160 | 13378-13383 | Protein | denotes | TRAF3 | |
T8159 | 11498-11514 | Protein | denotes | binding proteins | |
T8158 | 7259-7263 | Protein | denotes | IκBα | |
T8157 | 8460-8464 | Protein | denotes | NEMO | |
T8156 | 13469-13486 | Entity | denotes | by the proteasome | |
T8155 | 11184-11202 | Protein | denotes | TNF-receptor bound | |
T8154 | 8149-8175 | Entity | denotes | its K48-polyubiquitination | |
T8153 | 11776-11789 | Protein | denotes | polyubiquitin | |
T8152 | 15190-15199 | Protein | denotes | that CD40 | |
T8151 | 13777-13780 | Protein | denotes | NIK | |
T8150 | 7374-7379 | Protein | denotes | Bcl-3 | |
T8149 | 12385-12389 | Protein | denotes | IL-1 | |
T8148 | 7768-7818 | Protein | denotes | proinflammatory cytokines (for example, TNF, IL-1) | |
T8147 | 7830-7835 | Protein | denotes | RANKL | |
T8146 | 8044-8076 | Entity | denotes | of the IκB kinase (IKK) complex, | |
T8145 | 11455-11479 | Entity | denotes | the IKK and TAK1 complex | |
T8144 | 15384-15388 | Protein | denotes | TRAF | |
T8143 | 13290-13305 | Entity | denotes | most cell types | |
T8142 | 11621-11625 | Protein | denotes | NEMO | |
T8141 | 12220-12276 | Protein | denotes | myeloid differentiation primary response gene 88 (MyD88) | |
T8140 | 7179-7184 | Protein | denotes | NF-κB | |
T8139 | 11680-11693 | Protein | denotes | TNF-activated | |
T8138 | 15440-15445 | Protein | denotes | TRAF6 | |
T8137 | 10841-10887 | Protein | denotes | TNF receptor-1-associated death domain (TRADD) | |
T8136 | 15607-15630 | Entity | denotes | Specific TRAF molecules | |
T8135 | 11276-11283 | Protein | denotes | cIAP1/2 | |
T8134 | 7983-8000 | Protein | denotes | receptor specific | |
T8133 | 12156-12160 | Protein | denotes | TRAM | |
T8132 | 12741-12754 | Protein | denotes | lymphotoxin β | |
T8131 | 11484-11519 | Protein | denotes | the ubiquitin-binding proteins NEMO | |
T8130 | 10795-10798 | Protein | denotes | TNF | |
T8129 | 11276-11283 | Protein | denotes | cIAP1/2 | |
T8128 | 13179-13182 | Protein | denotes | NIK | |
T8127 | 7237-7281 | Protein | denotes | the majority of IκBs (IκBα, IκBβ, IκBε, p105 | |
T8126 | 10988-10997 | Protein | denotes | ubiquitin | |
T8125 | 10935-10939 | Protein | denotes | RIP1 | |
T8124 | 10838-10895 | Protein | denotes | of TNF receptor-1-associated death domain (TRADD) protein | |
T8123 | 7024-7038 | Protein | denotes | NF-κB proteins | |
T8122 | 11529-11530 | Protein | denotes | 2 | |
T8121 | 7481-7484 | Protein | denotes | p50 | |
T8120 | 7326-7332 | Protein | denotes | NF-κB2 | |
T8119 | 11488-11514 | Protein | denotes | ubiquitin-binding proteins | |
T8118 | 11964-11979 | Protein | denotes | other receptors | |
T8117 | 12518-12528 | Protein | denotes | TRAF6 [25] | |
T8116 | 13389-13396 | Protein | denotes | cIAP1/2 | |
T8115 | 10981-11045 | Protein | denotes | the E3 ubiquitin ligases TNF receptor-associated factor (TRAF) 2 | |
T8114 | 7808-7812 | Protein | denotes | TNF, | |
T8113 | 7820-7828 | Entity | denotes | antigens | |
T8112 | 13488-13496 | Protein | denotes | Receptor | |
T8111 | 15803-15808 | Protein | denotes | TRAF2 | |
T8110 | 7446-7450 | Protein | denotes | p105 | |
T8109 | 11167-11170 | Protein | denotes | TNF | |
T8108 | 8474-8478 | Protein | denotes | IKK1 | |
T8107 | 7058-7071 | Entity | denotes | the cytoplasm | |
T8106 | 15228-15232 | Protein | denotes | RANK | |
T8105 | 12445-12460 | Protein | denotes | oligomerisation | |
T8104 | 15489-15494 | Protein | denotes | TRAF2 | |
T8103 | 12703-12716 | Protein | denotes | NF-κB pathway | |
T8102 | 7536-7569 | Protein | denotes | NF-κB signalling pathways, termed | |
T8101 | 12842-12867 | Entity | denotes | by the proteasome to p52, | |
T8100 | 15422-15427 | Protein | denotes | TRAF3 | |
T8099 | 12326-12330 | Protein | denotes | TRIF | |
T8098 | 8507-8512 | Protein | denotes | NF-κB | |
T8097 | 11270-11271 | Protein | denotes | 5 | |
T8096 | 13546-13563 | Entity | denotes | from this complex | |
T8095 | 11231-11241 | Entity | denotes | K63-linked | |
T8094 | 12402-12415 | Protein | denotes | kinase (IRAK) | |
T8093 | 13310-13328 | Entity | denotes | unstimulated cells | |
T8092 | 12011-12032 | Entity | denotes | by lipopolysaccharide | |
T8091 | 13584-13597 | Protein | denotes | the receptor, | |
T8090 | 7024-7029 | Protein | denotes | NF-κB | |
T8089 | 8284-8288 | Protein | denotes | IKK2 | |
T8088 | 11488-11514 | Protein | denotes | ubiquitin-binding proteins | |
T8087 | 11308-11312 | Protein | denotes | RIP1 | |
T8086 | 15331-15346 | Entity | denotes | of their ligand | |
T8085 | 10749-10774 | Protein | denotes | NF-κB signalling pathways | |
T8084 | 12427-12433 | Protein | denotes | TRAF6, | |
T8083 | 11524-11530 | Protein | denotes | TAB1/2 | |
T8082 | 13051-13081 | Protein | denotes | The noncanonical NF-κB pathway | |
T8081 | 11405-11409 | Protein | denotes | RIP1 | |
T8080 | 11264-11271 | Protein | denotes | TRAF2/5 | |
T8079 | 12897-12902 | Protein | denotes | NF-κB | |
T8078 | 8192-8209 | Entity | denotes | by the proteasome | |
T8077 | 15348-15352 | Protein | denotes | CD40 | |
T8076 | 8224-8231 | Entity | denotes | complex | |
T8075 | 13185-13188 | Protein | denotes | NIK | |
T8074 | 13371-13376 | Protein | denotes | TRAF2 | |
T8073 | 7437-7441 | Protein | denotes | p100 | |
T8072 | 11902-11923 | Protein | denotes | the TAK1 complex [23] | |
T8071 | 12780-12784 | Protein | denotes | CD40 | |
T8070 | 15890-15913 | Protein | denotes | CD40 signalling [30,31] | |
T8069 | 13672-13677 | Protein | denotes | TRAF3 | |
T8068 | 12765-12778 | Protein | denotes | BAFF receptor | |
T8067 | 15717-15724 | Entity | denotes | B cells | |
T8066 | 8373-8398 | Protein | denotes | NEMO - also known as IKKγ | |
T8065 | 13330-13333 | Protein | denotes | NIK | |
T8064 | 12533-12537 | Protein | denotes | RIP1 | |
T8063 | 12737-12763 | Protein | denotes | the lymphotoxin β receptor | |
T8062 | 10903-10941 | Protein | denotes | receptor interacting protein 1 (RIP1), | |
T8061 | 8248-8279 | Protein | denotes | the two catalytic subunits IKK1 | |
T8060 | 10981-11045 | Protein | denotes | the E3 ubiquitin ligases TNF receptor-associated factor (TRAF) 2 | |
T8059 | 12790-12794 | Protein | denotes | RANK | |
T8058 | 7947-7954 | Protein | denotes | protein | |
T8057 | 15635-15689 | Protein | denotes | associated with overlapping and distinct CD40-mediated | |
T8056 | 11902-11923 | Entity | denotes | the TAK1 complex [23] | |
T8055 | 7645-7672 | Protein | denotes | The canonical NF-κB pathway | |
T8054 | 15357-15361 | Protein | denotes | RANK | |
T8053 | 7808-7817 | Protein | denotes | TNF, IL-1 | |
T8052 | 13389-13396 | Protein | denotes | cIAP1/2 | |
T8051 | 7344-7364 | Entity | denotes | inhibitors of NF-κB, | |
T8050 | 11083-11092 | Protein | denotes | ubiquitin | |
T8049 | 15616-15620 | Protein | denotes | TRAF | |
T8048 | 15415-15420 | Protein | denotes | TRAF2 | |
T8047 | 7473-7476 | Protein | denotes | p52 | |
T8046 | 11859-11872 | Protein | denotes | polyubiquitin | |
T7969 | 10778-10793 | Protein | denotes | the TNF pathway | |
T7968 | 11572-11710 | Protein | denotes | of a distinct E2/E3 enzyme complex that modifies NEMO with linear polyubiquitin chains and is essential for TNF-activated NF-κB signalling | |
T8045 | 7399-7404 | Protein | denotes | NF-κB | |
T8044 | 7629-7643 | Protein | denotes | NF-κB pathways | |
T8043 | 12824-12828 | Protein | denotes | p100 | |
T8042 | 11676-11710 | Protein | denotes | for TNF-activated NF-κB signalling | |
T8041 | 11242-11255 | Protein | denotes | polyubiquitin | |
T8040 | 8130-8214 | Protein | denotes | protein leading to its K48-polyubiquitination and degradation by the proteasome [20] | |
T8039 | 15201-15223 | Protein | denotes | lymphotoxin β receptor | |
T8038 | 11994-11998 | Protein | denotes | TLR4 | |
T8037 | 15717-15730 | Protein | denotes | B cells TRAF6 | |
T8036 | 8044-8076 | Protein | denotes | of the IκB kinase (IKK) complex, | |
T8035 | 7130-7164 | Entity | denotes | inhibitor of NF-κB (IκB) proteins, | |
T8034 | 8323-8399 | Protein | denotes | the regulatory subunit NF-κB essential modulator (NEMO - also known as IKKγ) | |
T8033 | 7297-7303 | Protein | denotes | NF-κB1 | |
T8032 | 15201-15214 | Protein | denotes | lymphotoxin β | |
T8031 | 12499-12503 | Protein | denotes | TRIF | |
T8030 | 7143-7163 | Protein | denotes | NF-κB (IκB) proteins | |
T8029 | 13725-13728 | Protein | denotes | NIK | |
T8028 | 13628-13636 | Protein | denotes | cIAP1/2, | |
T8027 | 13540-13545 | Protein | denotes | TRAF3 | |
T8026 | 12270-12275 | Protein | denotes | MyD88 | |
T8025 | 11467-11471 | Protein | denotes | TAK1 | |
T8024 | 11050-11056 | Protein | denotes | TRAF5, | |
T8023 | 13618-13623 | Protein | denotes | TRAF2 | |
T8022 | 7271-7275 | Protein | denotes | IκBε | |
T8021 | 15499-15504 | Protein | denotes | TRAF3 | |
T8020 | 11638-11651 | Protein | denotes | polyubiquitin | |
T8019 | 12484-12497 | Protein | denotes | of TRAF6 [24] | |
T8018 | 15836-15844 | Protein | denotes | of NF-κB | |
T8017 | 12655-12684 | Protein | denotes | to the TNF pathway (Figure 1) | |
T8016 | 7481-7490 | Protein | denotes | p50 NF-κB | |
T8015 | 11076-11141 | Protein | denotes | the E3 ubiquitin ligases cellular inhibitor of apoptosis (cIAP) 1 | |
T8014 | 11282-11283 | Protein | denotes | 2 | |
T8013 | 13798-13802 | Protein | denotes | IKK1 | |
T8012 | 11524-11530 | Protein | denotes | TAB1/2 | |
T8011 | 15780-15784 | Protein | denotes | IL-6 | |
T8010 | 7881-7903 | Protein | denotes | by different receptors | |
T8009 | 10968-11056 | Protein | denotes | proteins for the E3 ubiquitin ligases TNF receptor-associated factor (TRAF) 2 and TRAF5, | |
T8008 | 8394-8398 | Protein | denotes | IKKγ | |
T8007 | 7143-7154 | Protein | denotes | NF-κB (IκB) | |
T8006 | 8446-8455 | Protein | denotes | that IKK2 | |
T8005 | 7358-7363 | Protein | denotes | NF-κB | |
T8004 | 11184-11202 | Protein | denotes | TNF-receptor bound | |
T8003 | 12410-12414 | Protein | denotes | IRAK | |
T8002 | 7095-7114 | Protein | denotes | inhibitory proteins | |
T8001 | 13153-13183 | Protein | denotes | by NF-κB inducing kinase (NIK) | |
T8000 | 12939-12984 | Protein | denotes | target genes that control B-cell development, | |
T7999 | 12347-12352 | Protein | denotes | MyD88 | |
T7998 | 7927-8000 | Protein | denotes | of proximal protein-protein interactions that are often receptor specific | |
T7997 | 13395-13396 | Protein | denotes | 2 | |
T7996 | 12125-12162 | Protein | denotes | TRIF-related adaptor molecule (TRAM), | |
T7995 | 15429-15434 | Protein | denotes | TRAF5 | |
T7994 | 13344-13365 | Entity | denotes | a cytoplasmic complex | |
T7993 | 12765-12769 | Protein | denotes | BAFF | |
T7992 | 7306-7310 | Protein | denotes | p100 | |
T7991 | 12281-12331 | Protein | denotes | TIR domain-containing adaptor-inducing IFNβ (TRIF) | |
T7990 | 13104-13112 | Protein | denotes | on IKK1, | |
T7989 | 12057-12094 | Protein | denotes | of Toll/IL-1 receptor adaptor protein | |
T7988 | 11184-11207 | Protein | denotes | TNF-receptor bound RIP1 | |
T7987 | 15761-15764 | Protein | denotes | JNK | |
T7986 | 7365-7369 | Protein | denotes | IκBξ | |
T7985 | 7265-7276 | Protein | denotes | IκBβ, IκBε, | |
T7984 | 11264-11271 | Protein | denotes | TRAF2/5 | |
T7983 | 11146-11151 | Protein | denotes | cIAP2 | |
T7982 | 12116-12119 | Protein | denotes | Mal | |
T7981 | 15850-15855 | Protein | denotes | TRAF3 | |
T7980 | 7075-7114 | Entity | denotes | latent complexes by inhibitory proteins | |
T7979 | 15747-15760 | Protein | denotes | CD40-mediated | |
T7978 | 11572-11710 | Entity | denotes | of a distinct E2/E3 enzyme complex that modifies NEMO with linear polyubiquitin chains and is essential for TNF-activated NF-κB signalling | |
T7977 | 15256-15316 | Protein | denotes | of both canonical and noncanonical NF-κB signalling pathways | |
T7976 | 10881-10886 | Protein | denotes | TRADD | |
T7975 | 15408-15413 | Protein | denotes | TRAF1 | |
T7974 | 11759-11775 | Protein | denotes | protein-anchored | |
T7973 | 7424-7435 | Entity | denotes | the nucleus | |
T7972 | 7841-7852 | Entity | denotes | TLR ligands | |
T7971 | 12965-12971 | Entity | denotes | B-cell | |
T7970 | 11381-11394 | Protein | denotes | polyubiquitin | |
T3698 | 6929-6945 | Positive_regulation | denotes | NF-κB activation | |
T3697 | 4207-4242 | Binding | denotes | Binding of the CD40 ligand (CD154), | |
T3696 | 5406-5432 | Gene_expression | denotes | proteins derived from host | |
T3695 | 4325-4351 | Positive_regulation | denotes | NF-κB activation resulting | |
T3694 | 3394-3430 | Regulation | denotes | an effective treatment for severe RA | |
T3693 | 3644-3729 | Positive_regulation | denotes | NF-κB activation by receptor activator of NF-κB (RANK), a TNF receptor family member, | |
T3692 | 5154-5237 | Gene_expression | denotes | Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases | |
T3691 | 5613-5639 | Entity | denotes | various endogenous ligands | |
T3690 | 4215-4242 | Entity | denotes | of the CD40 ligand (CD154), | |
T3689 | 3702-3705 | Protein | denotes | TNF | |
T3688 | 5589-5591 | Protein | denotes | RA | |
T3665 | 6341-6367 | Protein | denotes | myeloid-related protein 14 | |
T3664 | 4118-4133 | Entity | denotes | dendritic cells | |
T3663 | 6004-6018 | Entity | denotes | by macrophages | |
T3662 | 6099-6103 | Protein | denotes | TLR4 | |
T3661 | 3282-3319 | Protein | denotes | proinflammatory cytokines such as TNF | |
T3660 | 6736-6747 | Protein | denotes | fibronectin | |
T3659 | 3552-3567 | Protein | denotes | these cytokines | |
T3658 | 3498-3503 | Protein | denotes | NF-κB | |
T3657 | 4101-4134 | Entity | denotes | macrophages, and dendritic cells, | |
T3656 | 3923-3931 | Protein | denotes | receptor | |
T3655 | 4076-4090 | Entity | denotes | synovial cells | |
T3654 | 6775-6791 | Entity | denotes | hyal-uronic acid | |
T3653 | 6982-6984 | Protein | denotes | RA | |
T3652 | 5738-5742 | Protein | denotes | mice | |
T3651 | 4957-4961 | Protein | denotes | BAFF | |
T3650 | 6183-6212 | Entity | denotes | HMGB1 neutralising antibodies | |
T3649 | 6311-6336 | Protein | denotes | Myeloid-related protein 8 | |
T3648 | 5475-5495 | Entity | denotes | candidate activators | |
T3647 | 5682-5684 | Protein | denotes | RA | |
T3646 | 5406-5432 | Protein | denotes | proteins derived from host | |
T3645 | 6929-6934 | Protein | denotes | NF-κB | |
T3644 | 3156-3158 | Protein | denotes | RA | |
T3643 | 6160-6162 | Protein | denotes | RA | |
T3642 | 4427-4438 | Protein | denotes | chemokines, | |
T3641 | 4836-4840 | Protein | denotes | BAFF | |
T3640 | 6504-6506 | Protein | denotes | RA | |
T3639 | 4057-4059 | Protein | denotes | RA | |
T3638 | 5954-5963 | Entity | denotes | chromatin | |
T3637 | 6724-6734 | Protein | denotes | fibrinogen | |
T3636 | 3450-3453 | Protein | denotes | TNF | |
T3635 | 3706-3714 | Protein | denotes | receptor | |
T3634 | 6749-6757 | Protein | denotes | biglycan | |
T3633 | 4705-4726 | Entity | denotes | pathogenic antibodies | |
T3632 | 4501-4523 | Protein | denotes | antagonistic anti-CD40 | |
T3631 | 4073-4075 | Protein | denotes | RA | |
T3630 | 3458-3462 | Protein | denotes | IL-1 | |
T3629 | 5331-5349 | Entity | denotes | microbial ligands, | |
T3628 | 3686-3698 | Protein | denotes | NF-κB (RANK) | |
T3627 | 6236-6253 | Entity | denotes | A domain of HMGB1 | |
T3626 | 6300-6309 | Protein | denotes | mice [16] | |
T3625 | 6121-6136 | Protein | denotes | in RA pathology | |
T3624 | 6447-6471 | Protein | denotes | calcium-binding proteins | |
T3623 | 3244-3249 | Protein | denotes | NF-κB | |
T3622 | 5312-5314 | Protein | denotes | RA | |
T3621 | 4015-4040 | Entity | denotes | smooth muscle fibroblasts | |
T3620 | 6684-6723 | Entity | denotes | extracellular matrix components such as | |
T3619 | 5499-5543 | Protein | denotes | TLRs inducing so-called sterile inflammation | |
T3618 | 4865-4880 | Protein | denotes | of autoantibody | |
T3617 | 6063-6136 | Entity | denotes | one of the most putative endogenous TLR4 ligands involved in RA pathology | |
T3616 | 3375-3390 | Entity | denotes | TNF antagonists | |
T3615 | 3919-3922 | Protein | denotes | TNF | |
T3614 | 6428-6472 | Protein | denotes | the S100 family of calcium-binding proteins, | |
T3613 | 6183-6212 | Protein | denotes | HMGB1 neutralising antibodies | |
T3612 | 6270-6286 | Entity | denotes | collagen-induced | |
T3611 | 3282-3315 | Protein | denotes | proinflammatory cytokines such as | |
T3610 | 4776-4816 | Entity | denotes | of the TNF receptor family member B-cell | |
T3609 | 4571-4580 | Protein | denotes | that CD40 | |
T3608 | 6635-6669 | Entity | denotes | ligands that may be involved in RA | |
T3607 | 4527-4548 | Entity | denotes | anti-CD154 antibodies | |
T3606 | 4235-4240 | Protein | denotes | CD154 | |
T3605 | 3622-3624 | Protein | denotes | RA | |
T3604 | 3693-3697 | Protein | denotes | RANK | |
T3603 | 3990-4004 | Entity | denotes | of cell types, | |
T3602 | 3417-3430 | Protein | denotes | for severe RA | |
T3601 | 6067-6136 | Entity | denotes | of the most putative endogenous TLR4 ligands involved in RA pathology | |
T3600 | 3105-3110 | Protein | denotes | NF-κB | |
T3599 | 6138-6143 | Protein | denotes | HMGB1 | |
T3598 | 5154-5180 | Protein | denotes | Toll-like receptors (TLRs) | |
T3597 | 5927-5932 | Protein | denotes | HMGB1 | |
T3596 | 4177-4205 | Protein | denotes | cytokines including TNF [10] | |
T3595 | 4197-4205 | Protein | denotes | TNF [10] | |
T3594 | 5280-5295 | Protein | denotes | NF-κB-dependent | |
T3593 | 5371-5432 | Entity | denotes | of endogenous ligands - a group of proteins derived from host | |
T3592 | 6248-6253 | Protein | denotes | HMGB1 | |
T3591 | 3903-3907 | Protein | denotes | CD40 | |
T3590 | 3782-3810 | Protein | denotes | proper RANK-NF-κB signalling | |
T3589 | 5145-5152 | Protein | denotes | RA [13] | |
T3588 | 6759-6767 | Protein | denotes | tenascin | |
T3587 | 6862-6910 | Entity | denotes | several TLR ligands in the inflamed joint tissue | |
T3586 | 5880-5934 | Protein | denotes | High mobility group box chromosomal protein 1 (HMGB1), | |
T3585 | 6405-6414 | Entity | denotes | molecules | |
T3584 | 3661-3682 | Protein | denotes | by receptor activator | |
T3687 | 6565-6577 | Protein | denotes | TLR4-induced | |
T3686 | 3375-3378 | Protein | denotes | TNF | |
T3685 | 4222-4226 | Protein | denotes | CD40 | |
T3684 | 5011-5044 | Protein | denotes | lymphotoxin β receptor signalling | |
T3683 | 4942-4961 | Entity | denotes | antagonists of BAFF | |
T3682 | 3840-3852 | Protein | denotes | RA pathology | |
T3681 | 3253-3255 | Protein | denotes | RA | |
T3680 | 4527-4548 | Protein | denotes | anti-CD154 antibodies | |
T3679 | 6664-6669 | Protein | denotes | in RA | |
T3678 | 3782-3810 | Protein | denotes | proper RANK-NF-κB signalling | |
T3677 | 6602-6604 | Protein | denotes | RA | |
T3676 | 4289-4314 | Entity | denotes | of activated CD4+ T cells | |
T3675 | 3467-3503 | Entity | denotes | both very potent activators of NF-κB | |
T3674 | 4092-4099 | Entity | denotes | B cells | |
T3673 | 4325-4330 | Protein | denotes | NF-κB | |
T3672 | 4783-4809 | Protein | denotes | TNF receptor family member | |
T3671 | 4413-4422 | Protein | denotes | cytokines | |
T3670 | 4934-4937 | Entity | denotes | RA, | |
T3669 | 3324-3328 | Protein | denotes | IL-1 | |
T3668 | 3532-3567 | Protein | denotes | NF-κB activation by these cytokines | |
T3667 | 3644-3649 | Protein | denotes | NF-κB | |
T3666 | 4892-4905 | Entity | denotes | B lymphocytes | |
T1590 | 3006-3044 | Positive_regulation | denotes | of NF-κB activation in RA pathogenesis | |
T1589 | 2116-2218 | Positive_regulation | denotes | NF-κB activation can be detected in cultured synovial fibroblasts and synovial tissue from RA patients | |
T1588 | 1229-1270 | Binding | denotes | infiltrating monocytes and synovial cells | |
T1587 | 1505-1539 | Regulation | denotes | of NF-κB-dependent gene expression | |
T1586 | 2859-2899 | Binding | denotes | a genetic association with several genes | |
T1585 | 1618-1623 | Protein | denotes | NF-κB | |
T1584 | 1746-1757 | Protein | denotes | RelA, RelB, | |
T1583 | 1746-1763 | Protein | denotes | RelA, RelB, c-Rel | |
T1582 | 2207-2209 | Protein | denotes | RA | |
T1581 | 1200-1225 | Protein | denotes | matrix metalloproteinases | |
T1580 | 2785-2819 | Protein | denotes | osteolytic diseases such as RA [7] | |
T1579 | 1508-1523 | Protein | denotes | NF-κB-dependent | |
T1578 | 2676-2681 | Protein | denotes | NF-κB | |
T1577 | 1120-1144 | Entity | denotes | proinflammatory T-helper | |
T1576 | 1932-1964 | Protein | denotes | inducible nitric oxide synthase, | |
T1575 | 3029-3044 | Protein | denotes | RA pathogenesis | |
T1574 | 1242-1251 | Entity | denotes | monocytes | |
T1573 | 2676-2696 | Entity | denotes | NF-κB ligand (RANKL) | |
T1572 | 2341-2346 | Protein | denotes | of RA | |
T1571 | 1868-1883 | Protein | denotes | genes - such as | |
T1570 | 1018-1026 | Entity | denotes | of cells | |
T1569 | 1889-1893 | Protein | denotes | IL-1 | |
T1568 | 1715-1721 | Protein | denotes | NF-κB2 | |
T1567 | 2035-2038 | Protein | denotes | TNF | |
T1566 | 3009-3014 | Protein | denotes | NF-κB | |
T1565 | 2690-2695 | Protein | denotes | RANKL | |
T1564 | 2063-2094 | Entity | denotes | very potent activators of NF-κB | |
T1563 | 1707-1711 | Protein | denotes | p100 | |
T1562 | 1752-1756 | Protein | denotes | RelB | |
T1561 | 2015-2020 | Protein | denotes | in RA | |
T1560 | 2953-2960 | Protein | denotes | TNFAIP3 | |
T1559 | 1731-1737 | Protein | denotes | NF-κB1 | |
T1558 | 2043-2047 | Protein | denotes | IL-1 | |
T1557 | 2116-2121 | Protein | denotes | NF-κB | |
T1556 | 1170-1182 | Protein | denotes | 17 cytokines | |
T1555 | 1782-1792 | Entity | denotes | homodimers | |
T1554 | 2571-2576 | Protein | denotes | NF-κB | |
T1553 | 1884-1894 | Protein | denotes | TNF, IL-1, | |
T1552 | 2297-2305 | Protein | denotes | of NF-κB | |
T1551 | 1286-1309 | Entity | denotes | of synovial fibroblasts | |
T1550 | 2456-2464 | Protein | denotes | of NF-κB | |
T1549 | 1184-1195 | Protein | denotes | chemokines, | |
T1548 | 1865-1975 | Protein | denotes | of genes - such as TNF, IL-1, IL-6, cyclo-oxygenase-2, chemokines, inducible nitric oxide synthase, and matrix | |
T1547 | 2966-2971 | Protein | denotes | c-REL | |
T1546 | 1579-1581 | Protein | denotes | RA | |
T1545 | 709-711 | Protein | denotes | RA | |
T1544 | 1145-1151 | Protein | denotes | type 1 | |
T1543 | 2940-2944 | Protein | denotes | CD40 | |
T1542 | 1901-1918 | Protein | denotes | cyclo-oxygenase-2 | |
T1541 | 1723-1727 | Protein | denotes | p105 | |
T1540 | 1156-1164 | Entity | denotes | T-helper | |
T1539 | 1697-1764 | Protein | denotes | proteins (p100 or NF-κB2, p105 or NF-κB1, p65 or RelA, RelB, c-Rel) | |
T1538 | 2881-2899 | Protein | denotes | with several genes | |
T1537 | 1256-1270 | Entity | denotes | synovial cells | |
T1536 | 2912-2929 | Protein | denotes | NF-κB signalling, | |
T1535 | 2152-2181 | Entity | denotes | cultured synovial fibroblasts | |
T1534 | 2654-2696 | Protein | denotes | receptor activator of NF-κB ligand (RANKL) | |
T1533 | 2946-2951 | Protein | denotes | TRAF1 | |
T1532 | 1434-1439 | Protein | denotes | of RA | |
T1531 | 1796-1808 | Entity | denotes | heterodimers | |
T1530 | 2089-2094 | Protein | denotes | NF-κB | |
T1529 | 1895-1919 | Protein | denotes | IL-6, cyclo-oxygenase-2, | |
T1528 | 1707-1742 | Protein | denotes | p100 or NF-κB2, p105 or NF-κB1, p65 | |
T239 | 572-585 | Regulation | denotes | control NF-κB | |
T238 | 193-237 | Binding | denotes | inappropriate NF-κB activity has been linked | |
T237 | 207-212 | Protein | denotes | NF-κB | |
T235 | 369-385 | Protein | denotes | NF-κB signalling | |
T234 | 108-113 | Protein | denotes | NF-κB | |
T233 | 318-323 | Entity | denotes | Cells | |
T232 | 580-585 | Protein | denotes | NF-κB | |
T231 | 475-480 | Protein | denotes | NF-κB | |
R201 | T232 | T239 | themeOf | NF-κB,control NF-κB | |
R1258 | T1538 | T1586 | themeOf | with several genes,a genetic association with several genes | |
R1263 | T1557 | T1589 | themeOf | NF-κB,NF-κB activation can be detected in cultured synovial fibroblasts and synovial tissue from RA patients | |
R1264 | T1566 | T1590 | themeOf | NF-κB,of NF-κB activation in RA pathogenesis | |
R1265 | T1579 | T1587 | causeOf | NF-κB-dependent,of NF-κB-dependent gene expression | |
R2747 | T3584 | T3693 | causeOf | by receptor activator,"NF-κB activation by receptor activator of NF-κB (RANK), a TNF receptor family member," | |
R2750 | T3598 | T3692 | themeOf | Toll-like receptors (TLRs),Toll-like receptors (TLRs) have been implicated in a variety of autoimmune diseases | |
R2768 | T3602 | T3694 | themeOf | for severe RA,an effective treatment for severe RA | |
R2772 | T3645 | T3698 | themeOf | NF-κB,NF-κB activation | |
R2773 | T3646 | T3696 | themeOf | proteins derived from host,proteins derived from host | |
R2774 | T3667 | T3693 | themeOf | NF-κB,"NF-κB activation by receptor activator of NF-κB (RANK), a TNF receptor family member," | |
R2775 | T3673 | T3695 | themeOf | NF-κB,NF-κB activation resulting | |
R5467 | T7978 | T8195 | causeOf | of a distinct E2/E3 enzyme complex that modifies NEMO with linear polyubiquitin chains and is essential for TNF-activated NF-κB signalling,of a distinct E2/E3 enzyme complex that modifies NEMO with linear polyubiquitin chains and is essential for TNF-activated NF-κB signalling | |
R5468 | T7979 | T8198 | causeOf | CD40-mediated,CD40-mediated JNK activation | |
R5471 | T7983 | T8179 | themeOf | cIAP2,which in turn bind the E3 ubiquitin ligases cellular inhibitor of apoptosis (cIAP) 1 and cIAP2 | |
R5472 | T7986 | T8176 | causeOf | IκBξ,IκBξ and Bcl-3 instead potentiate NF-κB transactivation in the nucleus | |
R5473 | T7987 | T8177 | themeOf | JNK,CD40-mediated JNK activation | |
R5474 | T7988 | T8171 | themeOf | TNF-receptor bound RIP1,TNF-receptor bound RIP1 | |
R5475 | T7989 | T8168 | themeOf | of Toll/IL-1 receptor adaptor protein,the recruitment of Toll/IL-1 receptor adaptor protein | |
R5479 | T7991 | T8192 | themeOf | TIR domain-containing adaptor-inducing IFNβ (TRIF),"to recruit myeloid differentiation primary response gene 88 (MyD88) and TIR domain-containing adaptor-inducing IFNβ (TRIF), respectively" | |
R5487 | T8011 | T8181 | themeOf | IL-6,"IL-6 production," | |
R5489 | T8013 | T8193 | themeOf | IKK1,IKK1 phosphorylation | |
R5491 | T8015 | T8178 | themeOf | the E3 ubiquitin ligases cellular inhibitor of apoptosis (cIAP) 1,which in turn bind the E3 ubiquitin ligases cellular inhibitor of apoptosis (cIAP) 1 and cIAP2 | |
R5493 | T8018 | T8197 | themeOf | of NF-κB,"activation of NF-κB," | |
R5495 | T8019 | T8189 | themeOf | of TRAF6 [24],ubiquitination of TRAF6 [24] | |
R5497 | T8023 | T8184 | themeOf | TRAF2,"to attract TRAF2 and cIAP1/2," | |
R5500 | T8027 | T8173 | themeOf | TRAF3,"to remove TRAF3 from this complex by recruiting it to the receptor," | |
R5501 | T8028 | T8184 | themeOf | "cIAP1/2,","to attract TRAF2 and cIAP1/2," | |
R5502 | T8029 | T8172 | themeOf | NIK,to releasing NIK | |
R5505 | T8037 | T8185 | themeOf | B cells TRAF6,B cells TRAF6 | |
R5506 | T8038 | T8206 | themeOf | TLR4,TLR4 stimulation by lipopolysaccharide | |
R5508 | T8039 | T8201 | causeOf | lymphotoxin β receptor,lymphotoxin β receptor and RANK mediate the activation of both canonical and noncanonical NF-κB signalling pathways | |
R5511 | T8042 | T8199 | themeOf | for TNF-activated NF-κB signalling,for TNF-activated NF-κB signalling | |
R5514 | T8045 | T8191 | themeOf | NF-κB,NF-κB transactivation in the nucleus | |
R5522 | T8057 | T8196 | themeOf | associated with overlapping and distinct CD40-mediated,associated with overlapping and distinct CD40-mediated | |
R5527 | T8064 | T8182 | themeOf | RIP1,also recruits TRAF6 [25] and RIP1 [26] via a direct interaction | |
R5530 | T8067 | T8185 | locationOf | B cells,B cells TRAF6 | |
R5532 | T8069 | T8203 | themeOf | TRAF3,for subsequent TRAF3 degradation | |
R5539 | T8087 | T8187 | themeOf | RIP1,"RIP1 ubiquitination," | |
R5544 | T8092 | T8206 | causeOf | by lipopolysaccharide,TLR4 stimulation by lipopolysaccharide | |
R5545 | T8098 | T8180 | themeOf | NF-κB,canonical NF-κB activation [21] | |
R5549 | T8106 | T8200 | causeOf | RANK,lymphotoxin β receptor and RANK mediate the activation of both canonical and noncanonical NF-κB signalling pathways | |
R5550 | T8109 | T8186 | themeOf | TNF,TNF stimulation | |
R5551 | T8203 | T8188 | themeOf | for subsequent TRAF3 degradation,which are essential for subsequent TRAF3 degradation | |
R5552 | T8117 | T8182 | themeOf | TRAF6 [25],also recruits TRAF6 [25] and RIP1 [26] via a direct interaction | |
R5553 | T8123 | T8174 | themeOf | NF-κB proteins,NF-κB proteins are sequestered in the cytoplasm as latent complexes by inhibitory proteins | |
R5554 | T8124 | T8169 | themeOf | of TNF receptor-1-associated death domain (TRADD) protein,in the recruitment of TNF receptor-1-associated death domain (TRADD) protein | |
R5555 | T8130 | T8183 | themeOf | TNF,TNF stimulation | |
R5556 | T8139 | T8199 | causeOf | TNF-activated,for TNF-activated NF-κB signalling | |
R5557 | T8141 | T8192 | themeOf | myeloid differentiation primary response gene 88 (MyD88),"to recruit myeloid differentiation primary response gene 88 (MyD88) and TIR domain-containing adaptor-inducing IFNβ (TRIF), respectively" | |
R5558 | T8142 | T8195 | themeOf | NEMO,of a distinct E2/E3 enzyme complex that modifies NEMO with linear polyubiquitin chains and is essential for TNF-activated NF-κB signalling | |
R5559 | T8145 | T8194 | themeOf | the IKK and TAK1 complex,to recruit the IKK and TAK1 complex via the ubiquitin-binding proteins NEMO and TAB1/2 | |
R5560 | T8150 | T8175 | causeOf | Bcl-3,IκBξ and Bcl-3 instead potentiate NF-κB transactivation in the nucleus | |
R5561 | T8151 | T8202 | themeOf | NIK,NIK accumulation | |
R5562 | T8155 | T8171 | themeOf | TNF-receptor bound,TNF-receptor bound RIP1 | |
R5563 | T8159 | T8170 | themeOf | binding proteins,binding proteins | |
R5564 | T8177 | T8198 | themeOf | CD40-mediated JNK activation,CD40-mediated JNK activation | |
R5565 | T8191 | T8175 | themeOf | NF-κB transactivation in the nucleus,IκBξ and Bcl-3 instead potentiate NF-κB transactivation in the nucleus | |
R5566 | T8191 | T8176 | themeOf | NF-κB transactivation in the nucleus,IκBξ and Bcl-3 instead potentiate NF-κB transactivation in the nucleus | |
R6314 | T9292 | T9334 | themeOf | nuclear NF-κB,inhibit nuclear NF-κB | |
R6315 | T9300 | T9339 | themeOf | of the noncanonical NF-κB,regulation of the noncanonical NF-κB | |
R6316 | T9303 | T9331 | themeOf | of NF-κB,the control of NF-κB | |
R6317 | T9305 | T9335 | themeOf | IKK2,enhanced IKK2 activation | |
R6318 | T9306 | T9336 | themeOf | NF-κB,NF-κB activation | |
R6319 | T9307 | T9332 | themeOf | NF-κB,persistent NF-κB activation | |
R6320 | T9308 | T9330 | themeOf | NIK,"Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback" | |
R6321 | T9311 | T9337 | themeOf | IκBα,IκBα degradation | |
R6322 | T9313 | T9330 | causeOf | IKK1,"Interestingly, a recent study has demonstrated that IKK1 phosphorylates NIK in negative feedback" | |
R6323 | T9316 | T9338 | themeOf | STAT1 [35],phosphorylating STAT1 [35] | |
R6324 | T9319 | T9333 | themeOf | inactive IKK1,expressing inactive IKK1 | |
R6325 | T9332 | T9327 | themeOf | persistent NF-κB activation,prevent persistent NF-κB activation | |
R6326 | T9335 | T9329 | themeOf | enhanced IKK2 activation,enhanced IKK2 activation | |
R8261 | T12283 | T12406 | themeOf | A20,could show repressed A20 transcription | |
R8270 | T12286 | T12407 | locationOf | B cells,"that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells" | |
R8271 | T12289 | T12414 | themeOf | A20,A20 expression | |
R8273 | T12314 | T12407 | locationOf | T cells,"that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells" | |
R8274 | T12316 | T12410 | themeOf | A20,A20 expression | |
R8275 | T12325 | T12407 | locationOf | specific cell types such as synovial fibroblasts,"that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells" | |
R8276 | T12326 | T12409 | themeOf | ubiquitin,specific ubiquitin-binding | |
R8277 | T12330 | T12407 | themeOf | "that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells","that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells" | |
R8278 | T12335 | T12404 | themeOf | NF-κB,NF-κB activation | |
R8279 | T12342 | T12407 | locationOf | macrophages,"that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells" | |
R8280 | T12346 | T12405 | themeOf | of A20,The association of A20 | |
R8281 | T12352 | T12413 | themeOf | A20,"by NF-κB [50], implicating A20" | |
R8282 | T12358 | T12419 | causeOf | NF-κB-dependent,NF-κB-dependent gene expression | |
R8283 | T12366 | T12418 | themeOf | a major antiapoptotic protein in the intestinal epithelium [47],a major antiapoptotic protein in the intestinal epithelium [47] | |
R8284 | T12387 | T12407 | locationOf | dendritic cells,"that lack A20 in specific cell types such as synovial fibroblasts, macrophages, dendritic cells, B cells or T cells" | |
R8285 | T12401 | T12415 | themeOf | A20,A20 overexpression | |
R8286 | T12401 | T12416 | themeOf | A20,A20 overexpression | |
R8287 | T12402 | T12385 | partOf | A20 promoter,A20 | |
R8288 | T12404 | T12408 | themeOf | NF-κB activation,"suppressing NF-κB activation," | |
R8289 | T12405 | T12417 | themeOf | The association of A20,The association of A20 with its targets requires specific ubiquitin-binding | |
R8290 | T12406 | T12411 | themeOf | could show repressed A20 transcription,repressed A20 transcription | |
R8291 | T12409 | T12417 | causeOf | specific ubiquitin-binding,The association of A20 with its targets requires specific ubiquitin-binding | |
R9283 | T13898 | T13952 | causeOf | TNF-induced,"TNF-induced genes in human synoviocytes," | |
R9284 | T13902 | T13957 | themeOf | Functional ABIN-3,Functional ABIN-3 is expressed in humans | |
R9285 | T13904 | T13956 | themeOf | autoantibody,autoantibody production | |
R9286 | T13911 | T13954 | locationOf | "human synoviocytes,","TNF-induced genes in human synoviocytes," | |
R9287 | T13923 | T13959 | themeOf | A20 interacting proteins,A20 interacting proteins | |
R9288 | T13924 | T13958 | themeOf | NF-κB,of NF-κB activation | |
R9289 | T13932 | T13952 | themeOf | "TNF-induced genes in human synoviocytes,","TNF-induced genes in human synoviocytes," | |
R9290 | T13932 | T13953 | themeOf | "TNF-induced genes in human synoviocytes,","TNF-induced genes in human synoviocytes," | |
R9291 | T13932 | T13954 | themeOf | "TNF-induced genes in human synoviocytes,","TNF-induced genes in human synoviocytes," | |
R9292 | T13936 | T13955 | themeOf | of the NF-κB inhibitory proteins ABIN-3 and A20,on the expression of the NF-κB inhibitory proteins ABIN-3 and A20 | |
R9293 | T13942 | T13951 | themeOf | A20 interacting proteins,ubiquitously expressed A20 interacting proteins and were shown to inhibit NF-κB activation by TNF and several | |
R10144 | T15304 | T15358 | themeOf | NF-κB,"that negatively regulates NF-κB signalling initiated by TNFR, RANK and T-cell receptor stimulation" | |
R10145 | T15304 | T15366 | themeOf | NF-κB,NF-κB signalling initiated | |
R10146 | T15307 | T15363 | themeOf | T-cell receptor,T-cell receptor stimulation | |
R10147 | T15307 | T15364 | themeOf | T-cell receptor,T-cell receptor | |
R10148 | T15312 | T15362 | causeOf | CYLD-mediated,by the CYLD-mediated deubiquitination of TRAF6 | |
R10149 | T15314 | T15361 | themeOf | CYLD,CYLD expression | |
R10150 | T15329 | T15360 | causeOf | A20 as well as CYLD,A20 as well as CYLD to control NF-κB activation | |
R10151 | T15330 | T15367 | themeOf | ubiquitinated TRAF6,ubiquitinated TRAF6 | |
R10152 | T15339 | T15364 | locationOf | T-cell,T-cell receptor | |
R10153 | T15343 | T15365 | causeOf | CYLD,"Interestingly, CYLD has been shown to negatively regulate RANK signalling and osteoclastogenesis in mice [65]" | |
R10154 | T15345 | T15365 | themeOf | RANK signalling and osteoclastogenesis in mice [65],"Interestingly, CYLD has been shown to negatively regulate RANK signalling and osteoclastogenesis in mice [65]" | |
R10155 | T15349 | T15359 | themeOf | NF-κB,NF-κB activation | |
R10156 | T15359 | T15360 | themeOf | NF-κB activation,A20 as well as CYLD to control NF-κB activation | |
R10735 | T16202 | T16240 | themeOf | MyD88,"direct interaction with these receptors, MyD88, IRAK1 or TRAF6 [67] (Figure 1)" | |
R10736 | T16211 | T16240 | themeOf | TRAF6 [67],"direct interaction with these receptors, MyD88, IRAK1 or TRAF6 [67] (Figure 1)" | |
R10737 | T16212 | T16242 | causeOf | by human RA synovial cells,the spontaneous release of inflammatory cytokines by human RA synovial cells | |
R10738 | T16217 | T16242 | themeOf | of inflammatory cytokines,the spontaneous release of inflammatory cytokines by human RA synovial cells | |
R10739 | T16230 | T16241 | themeOf | of SIGIRR,to compare the expression of SIGIRR in RA patients with its expression in control | |
R10740 | T16233 | T16240 | themeOf | IRAK1,"direct interaction with these receptors, MyD88, IRAK1 or TRAF6 [67] (Figure 1)" | |
R10741 | T16236 | T16245 | themeOf | SIGIRR,SIGIRR overexpression | |
R10742 | T16236 | T16246 | themeOf | SIGIRR,SIGIRR overexpression | |
R10743 | T16237 | T16240 | themeOf | these receptors,"direct interaction with these receptors, MyD88, IRAK1 or TRAF6 [67] (Figure 1)" | |
R10744 | T16242 | T16243 | themeOf | the spontaneous release of inflammatory cytokines by human RA synovial cells,"Recently, SIGIRR overexpression was shown to inhibit the spontaneous release of inflammatory cytokines by human RA synovial cells" | |
R10745 | T16242 | T16244 | themeOf | the spontaneous release of inflammatory cytokines by human RA synovial cells,"Recently, SIGIRR overexpression was shown to inhibit the spontaneous release of inflammatory cytokines by human RA synovial cells" | |
R10746 | T16245 | T16244 | causeOf | SIGIRR overexpression,"Recently, SIGIRR overexpression was shown to inhibit the spontaneous release of inflammatory cytokines by human RA synovial cells" | |
R10747 | T16246 | T16243 | causeOf | SIGIRR overexpression,"Recently, SIGIRR overexpression was shown to inhibit the spontaneous release of inflammatory cytokines by human RA synovial cells" | |
R11362 | T17222 | T17264 | themeOf | other signalling proteins,binding to the receptor or other signalling proteins | |
R11363 | T17223 | T17259 | themeOf | of TRAF1,Expression of TRAF1 | |
R11364 | T17233 | T17264 | themeOf | the receptor,binding to the receptor or other signalling proteins | |
R11365 | T17235 | T17261 | themeOf | NF-κB,TNF-induced NF-κB activation | |
R11366 | T17244 | T17258 | causeOf | TRAF1,by TNF and overexpression of TRAF1 inhibits TNF-induced NF-κB activation | |
R11367 | T17248 | T17263 | themeOf | NF-κB,CD40-induced NF-κB activation | |
R11368 | T17257 | T17260 | themeOf | A20,recruit A20 | |
R11369 | T17261 | T17258 | themeOf | TNF-induced NF-κB activation,by TNF and overexpression of TRAF1 inhibits TNF-induced NF-κB activation | |
R12451 | T18786 | T18853 | themeOf | protein,of protein expression | |
R12452 | T18811 | T18866 | themeOf | mRNA,of target mRNA degradation | |
R12453 | T18817 | T18858 | themeOf | matrix metalloproteinase-1,to increased secretion of matrix metalloproteinase-1 and IL-6 | |
R12454 | T18833 | T18867 | themeOf | miR-155,"Notably, both miR-146 and miR-155 are expressed at higher levels in RA synovial fibroblasts" | |
R12455 | T18835 | T18860 | themeOf | miR-155,miR-155 overexpression in synovial fibroblasts | |
R12456 | T18835 | T18861 | themeOf | miR-155,miR-155 overexpression in synovial fibroblasts | |
R12457 | T18839 | T18864 | causeOf | of specific matrix metalloproteinases that mediate tissue destruction in RA [81],of specific matrix metalloproteinases that mediate tissue destruction in RA [81] | |
R12458 | T18839 | T18865 | themeOf | of specific matrix metalloproteinases that mediate tissue destruction in RA [81],cytokine-inducible expression of specific matrix metalloproteinases that mediate tissue destruction in RA [81] | |
R12459 | T18845 | T18862 | themeOf | miR-146a,"miR-146a is also overexpressed in CD4+ and IL-17-producing T cells from RA patients [84,85]" | |
R12460 | T18845 | T18863 | themeOf | miR-146a,"miR-146a is also overexpressed in CD4+ and IL-17-producing T cells from RA patients [84,85]" | |
R12461 | T18850 | T18859 | themeOf | IL-6,to increased secretion of matrix metalloproteinase-1 and IL-6 | |
R12462 | T18858 | T18854 | themeOf | to increased secretion of matrix metalloproteinase-1 and IL-6,to increased secretion of matrix metalloproteinase-1 and IL-6 | |
R12463 | T18859 | T18855 | themeOf | to increased secretion of matrix metalloproteinase-1 and IL-6,to increased secretion of matrix metalloproteinase-1 and IL-6 | |
R12464 | T18866 | T18856 | themeOf | of target mRNA degradation,the promotion of target mRNA degradation [77] | |
R12748 | T19198 | T19203 | themeOf | NF-κB,NF-κB activation | |
R13883 | T21072 | T21183 | themeOf | TRAFs,"K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1," | |
R13884 | T21076 | T21186 | themeOf | TRAF6,binding to IRAK1 and TRAF6 | |
R13885 | T21077 | T21173 | themeOf | membrane receptors,membrane receptors | |
R13886 | T21084 | T21190 | causeOf | TAK1,"TAK1 then phosphorylates and activates IKK2," | |
R13887 | T21088 | T21181 | themeOf | RIP1,"K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1," | |
R13888 | T21089 | T21192 | causeOf | NF-κB dependent,The expression of many of these negative regulatory molecules is NF-κB dependent | |
R13889 | T21104 | T21179 | themeOf | NF-κB activation,that control NF-κB activation by targeting specific signalling proteins including RIP1 and TRAF6 | |
R13890 | T21106 | T21180 | themeOf | NF-κB,"NF-κB activation," | |
R13891 | T21110 | T21187 | themeOf | "IκBα,","which in turn phosphorylates IκBα," | |
R13892 | T21118 | T21173 | locationOf | membrane,membrane receptors | |
R13893 | T21121 | T21185 | themeOf | adaptor proteins,specific ubiquitin-binding adaptor proteins such | |
R13894 | T21141 | T21182 | themeOf | IRAK1,"K63-linked polyubiquitination of TRAFs, RIP1 and IRAK1," | |
R13895 | T21152 | T21184 | themeOf | NF-κB,of NF-κB activation | |
R13896 | T21153 | T21188 | themeOf | IRAK1,expression of IRAK1 and TRAF6 | |
R13897 | T21154 | T21186 | themeOf | IRAK1,binding to IRAK1 and TRAF6 | |
R13898 | T21155 | T21191 | themeOf | "inhibited by the transmembrane protein SIGIRR,","inhibited by the transmembrane protein SIGIRR," | |
R13899 | T21162 | T21191 | causeOf | by the transmembrane protein,"inhibited by the transmembrane protein SIGIRR," | |
R13900 | T21163 | T21185 | themeOf | specific ubiquitin-binding adaptor proteins such,specific ubiquitin-binding adaptor proteins such | |
R13901 | T21164 | T21190 | themeOf | "IKK2,","TAK1 then phosphorylates and activates IKK2," | |
R13902 | T21167 | T21189 | themeOf | TRAF6,expression of IRAK1 and TRAF6 | |
R13903 | T21180 | T21177 | themeOf | "NF-κB activation,","can negatively regulate NF-κB activation, most probably by competing with other TRAFs" | |
R13904 | T21188 | T21174 | themeOf | expression of IRAK1 and TRAF6,inhibiting expression of IRAK1 and TRAF6 | |
R13905 | T21189 | T21175 | themeOf | expression of IRAK1 and TRAF6,inhibiting expression of IRAK1 and TRAF6 | |
R14595 | T22423 | T22484 | themeOf | NF-κB p100,NF-κB p100 phosphorylation | |
R14596 | T22426 | T22483 | themeOf | "of NIK, keeping NIK levels low","proteasomal degradation of NIK, keeping NIK levels low" | |
R14597 | T22429 | T22475 | themeOf | NIK,NIK is stabilised | |
R14598 | T22438 | T22479 | causeOf | TRAF2,"where TRAF2 directs nondegradative K63-linked polyubiquitination of cIAP1/2, resulting in their activation" | |
R14599 | T22444 | T22474 | themeOf | TNF receptor-associated factor; TNF,TNF receptor-associated factor; TNF | |
R14600 | T22445 | T22480 | themeOf | of p100,"partial proteasomal degradation of p100 to p52," | |
R14601 | T22447 | T22474 | themeOf | TNF receptor-associated,TNF receptor-associated factor; TNF | |
R14602 | T22449 | T22478 | themeOf | "IKK1,","NIK then phosphorylates and activates IKK1," | |
R14603 | T22462 | T22478 | causeOf | NIK,"NIK then phosphorylates and activates IKK1," | |
R14604 | T22463 | T22477 | causeOf | cIAP1/2,"Subsequently cIAP1/2 directs its K48-linked polyubiquitination to TRAF3, rather than NIK" | |
R14605 | T22465 | T22481 | themeOf | K48-linked,its K48-linked polyubiquitination | |
R14606 | T22466 | T22486 | themeOf | TRAF3,TRAF3 is degraded | |
R14607 | T22467 | T22485 | themeOf | NF-κB inducing kinase (NIK),on NF-κB inducing kinase (NIK) expression | |
R14608 | T22484 | T22476 | themeOf | NF-κB p100 phosphorylation,which mediates NF-κB p100 phosphorylation |
bionlp-st-ge-2016-test-tees
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T22308 | 15143-15165 | Protein | denotes | tumour necrosis factor |
T22307 | 15138-15141 | Protein | denotes | TNF |
T22306 | 15106-15136 | Protein | denotes | TNF receptor-associated factor |
T22305 | 15100-15104 | Protein | denotes | TRAF |
T22304 | 15093-15098 | Protein | denotes | NF-κB |
T22303 | 15065-15069 | Protein | denotes | RANK |
T22302 | 15045-15063 | Protein | denotes | NF, nuclear factor |
T22301 | 15033-15043 | Protein | denotes | IκB kinase |
T22300 | 15028-15031 | Protein | denotes | IKK |
T22299 | 14935-14944 | Binding | denotes | competing |
T22277 | 14555-14558 | Protein | denotes | NIK |
T22276 | 14513-14516 | Protein | denotes | NIK |
T22275 | 14491-14496 | Protein | denotes | TRAF3 |
T22274 | 14473-14476 | Protein | denotes | NIK |
T22273 | 14454-14459 | Protein | denotes | TRAF3 |
T22272 | 14253-14262 | Binding | denotes | recruited |
T22271 | 14235-14242 | Binding | denotes | binding |
T22270 | 14348-14355 | Protein | denotes | cIAP1/2 |
T22269 | 14286-14291 | Protein | denotes | TRAF2 |
T22268 | 14244-14249 | Protein | denotes | TRAF3 |
T22267 | 14179-14190 | Protein_catabolism | denotes | degradation |
T22266 | 14207-14210 | Protein | denotes | NIK |
T20894 | 10701-10723 | Protein | denotes | tumour necrosis factor |
T20893 | 10696-10699 | Protein | denotes | TNF |
T20892 | 10676-10694 | Protein | denotes | Toll-like receptor |
T20891 | 10671-10674 | Protein | denotes | TLR |
T20890 | 10639-10669 | Protein | denotes | TNF receptor-associated factor |
T20889 | 10633-10637 | Protein | denotes | TRAF |
T20888 | 10626-10631 | Protein | denotes | IL-1R |
T20887 | 10607-10625 | Protein | denotes | Toll-like receptor |
T20886 | 10602-10605 | Protein | denotes | TIR |
T20885 | 10558-10592 | Protein | denotes | single-immunoglobulinIL-1 receptor |
T20884 | 10550-10556 | Protein | denotes | SIGIRR |
T20883 | 10518-10548 | Protein | denotes | receptor interacting protein 1 |
T20882 | 10512-10516 | Protein | denotes | RIP1 |
T20881 | 10505-10510 | Protein | denotes | NF-κB |
T20880 | 10477-10481 | Protein | denotes | RANK |
T20879 | 10430-10435 | Protein | denotes | NF-κB |
T20878 | 10424-10428 | Protein | denotes | NEMO |
T20877 | 10367-10372 | Protein | denotes | MyD88 |
T20876 | 10342-10347 | Protein | denotes | IL-1R |
T20875 | 10336-10340 | Protein | denotes | IRAK |
T20874 | 10329-10334 | Protein | denotes | NF-κB |
T20873 | 10311-10314 | Protein | denotes | IκB |
T20872 | 10299-10309 | Protein | denotes | IκB kinase |
T20871 | 10294-10297 | Protein | denotes | IKK |
T20870 | 10232-10236 | Protein | denotes | cIAP |
T20869 | 10225-10230 | Protein | denotes | NF-κB |
T20868 | 10176-10181 | Protein | denotes | NF-κB |
T20867 | 10103-10108 | Protein | denotes | NF-κB |
T20866 | 10010-10017 | Binding | denotes | binding |
T20865 | 10010-10017 | Binding | denotes | binding |
T20864 | 9988-9995 | Binding | denotes | compete |
T20863 | 9914-9923 | Negative_regulation | denotes | inhibited |
T20862 | 10031-10036 | Protein | denotes | TRAF6 |
T20861 | 10021-10026 | Protein | denotes | IRAK1 |
T20860 | 10001-10005 | Protein | denotes | TLR4 |
T20859 | 9887-9890 | Protein | denotes | TLR |
T20858 | 9809-9817 | Regulation | denotes | regulate |
T20857 | 9809-9817 | Regulation | denotes | regulate |
T20856 | 9836-9846 | Negative_regulation | denotes | inhibiting |
T20855 | 9836-9846 | Negative_regulation | denotes | inhibiting |
T20854 | 9847-9857 | Gene_expression | denotes | expression |
T20853 | 9847-9857 | Gene_expression | denotes | expression |
T20852 | 9871-9876 | Protein | denotes | TRAF6 |
T20851 | 9861-9866 | Protein | denotes | IRAK1 |
T20850 | 9818-9821 | Protein | denotes | TLR |
T20849 | 9581-9588 | Regulation | denotes | control |
T20848 | 9581-9588 | Regulation | denotes | control |
T20847 | 9595-9605 | Positive_regulation | denotes | activation |
T20846 | 9771-9774 | Protein | denotes | p62 |
T20845 | 9667-9672 | Protein | denotes | TRAF6 |
T20844 | 9658-9662 | Protein | denotes | RIP1 |
T20843 | 9589-9594 | Protein | denotes | NF-κB |
T20842 | 9542-9546 | Protein | denotes | CYLD |
T20841 | 9534-9537 | Protein | denotes | A20 |
T20840 | 9462-9470 | Regulation | denotes | regulate |
T20839 | 9506-9515 | Binding | denotes | competing |
T20838 | 9477-9487 | Positive_regulation | denotes | activation |
T20837 | 9527-9532 | Protein | denotes | TRAFs |
T20836 | 9471-9476 | Protein | denotes | NF-κB |
T20835 | 9420-9436 | Protein | denotes | ubiquitin ligase |
T20834 | 9400-9405 | Protein | denotes | TRAF1 |
T20833 | 9337-9348 | Localization | denotes | translocate |
T20832 | 9356-9363 | Entity | denotes | nucleus |
T20831 | 9329-9332 | Protein | denotes | p50 |
T20830 | 9321-9324 | Protein | denotes | p65 |
T20829 | 9283-9288 | Protein | denotes | NF-κB |
T20828 | 9201-9211 | Positive_regulation | denotes | triggering |
T20827 | 9258-9269 | Protein_catabolism | denotes | degradation |
T20826 | 9180-9194 | Phosphorylation | denotes | phosphorylates |
T20825 | 9180-9194 | Phosphorylation | denotes | phosphorylates |
T20824 | 9150-9159 | Positive_regulation | denotes | activates |
T20823 | 9131-9145 | Phosphorylation | denotes | phosphorylates |
T20822 | 9195-9199 | Protein | denotes | IκBα |
T20821 | 9160-9164 | Protein | denotes | IKK2 |
T20820 | 9121-9125 | Protein | denotes | TAK1 |
T20819 | 9063-9074 | Binding | denotes | recruitment |
T20818 | 8961-8979 | Localization | denotes | polyubiquitination |
T20817 | 8961-8979 | Localization | denotes | polyubiquitination |
T20816 | 9115-9119 | Protein | denotes | TAK1 |
T20815 | 9106-9110 | Protein | denotes | IKK2 |
T20814 | 9032-9044 | Protein | denotes | TAB proteins |
T20813 | 9023-9027 | Protein | denotes | NEMO |
T20812 | 8999-9004 | Protein | denotes | IRAK1 |
T20811 | 8990-8994 | Protein | denotes | RIP1 |
T20810 | 8983-8988 | Protein | denotes | TRAFs |
T20809 | 8926-8931 | Protein | denotes | cIAP2 |
T20808 | 8919-8924 | Protein | denotes | cIAP1 |
T20807 | 8912-8917 | Protein | denotes | TRAF6 |
T20806 | 8905-8910 | Protein | denotes | TRAF2 |
T20805 | 8886-8903 | Protein | denotes | ubiquitin ligases |
T20804 | 8874-8879 | Protein | denotes | IRAK4 |
T20803 | 8867-8872 | Protein | denotes | IRAK1 |
T19049 | 33514-33519 | Protein | denotes | NF-κB |
T19048 | 33134-33144 | Regulation | denotes | regulation |
T19047 | 33152-33157 | Protein | denotes | NF-κB |
T19046 | 32978-32988 | Positive_regulation | denotes | activation |
T19045 | 32972-32977 | Protein | denotes | NF-κB |
T19044 | 32827-32839 | Protein | denotes | NF-κB family |
T18634 | 32521-32530 | Positive_regulation | denotes | increased |
T18633 | 32521-32530 | Positive_regulation | denotes | increased |
T18632 | 32510-32517 | Positive_regulation | denotes | leading |
T18631 | 32510-32517 | Positive_regulation | denotes | leading |
T18630 | 32531-32540 | Localization | denotes | secretion |
T18629 | 32531-32540 | Localization | denotes | secretion |
T18628 | 32575-32579 | Protein | denotes | IL-6 |
T18627 | 32544-32570 | Protein | denotes | matrix metalloproteinase-1 |
T18626 | 32421-32430 | Negative_regulation | denotes | decreased |
T18625 | 32358-32402 | Protein | denotes | chemokine monocyte chemoattractant protein 1 |
T18624 | 32324-32332 | Protein | denotes | miR-124a |
T18623 | 32226-32231 | Protein | denotes | NF-κB |
T18622 | 31672-31679 | Positive_regulation | denotes | promote |
T18621 | 31684-31694 | Gene_expression | denotes | production |
T18620 | 31680-31683 | Protein | denotes | TNF |
T18619 | 31509-31516 | Negative_regulation | denotes | prevent |
T18618 | 31548-31558 | Gene_expression | denotes | expression |
T18617 | 31578-31596 | Protein | denotes | metalloproteinases |
T18616 | 31364-31372 | Protein | denotes | miR-146a |
T18615 | 31263-31278 | Gene_expression | denotes | IL-17-producing |
T18614 | 31237-31250 | Positive_regulation | denotes | overexpressed |
T18613 | 31254-31258 | Protein | denotes | CD4+ |
T18612 | 31220-31228 | Protein | denotes | miR-146a |
T18611 | 31067-31076 | Gene_expression | denotes | expressed |
T18610 | 31067-31076 | Gene_expression | denotes | expressed |
T18609 | 31055-31062 | Protein | denotes | miR-155 |
T18608 | 31043-31050 | Protein | denotes | miR-146 |
T18607 | 31020-31026 | Entity | denotes | [79,80 |
T18606 | 30996-31019 | Protein | denotes | molecules IKKε and RIP1 |
T17119 | 29059-29073 | Positive_regulation | denotes | overexpression |
T17118 | 29059-29073 | Gene_expression | denotes | overexpression |
T17117 | 29038-29047 | Positive_regulation | denotes | inducible |
T17116 | 29015-29025 | Gene_expression | denotes | Expression |
T17115 | 29104-29109 | Protein | denotes | NF-κB |
T17114 | 29092-29095 | Protein | denotes | TNF |
T17113 | 29077-29082 | Protein | denotes | TRAF1 |
T17112 | 29051-29054 | Protein | denotes | TNF |
T17111 | 29029-29034 | Protein | denotes | TRAF1 |
T17110 | 28943-28963 | Protein | denotes | TNF family receptors |
T17109 | 28915-28920 | Protein | denotes | NF-κB |
T17108 | 28862-28867 | Protein | denotes | TRAF1 |
T17107 | 28792-28797 | Negative_regulation | denotes | lacks |
T17106 | 28798-28814 | Protein | denotes | ubiquitin ligase |
T17105 | 28720-28724 | Protein | denotes | TRAF |
T17104 | 28688-28693 | Protein | denotes | TRAF1 |
T17103 | 28655-28685 | Protein | denotes | TNF receptor-associated factor |
T15812 | 28574-28584 | Gene_expression | denotes | expression |
T15811 | 28594-28600 | Protein | denotes | SIGIRR |
T15810 | 28510-28516 | Protein | denotes | SIGIRR |
T15809 | 28307-28315 | Protein | denotes | collagen |
T15808 | 28168-28174 | Protein | denotes | SIGIRR |
T15807 | 28026-28040 | Positive_regulation | denotes | overexpression |
T15806 | 28026-28040 | Gene_expression | denotes | overexpression |
T15805 | 28019-28025 | Protein | denotes | SIGIRR |
T15804 | 27709-27713 | Positive_regulation | denotes | role |
T15803 | 27709-27713 | Positive_regulation | denotes | role |
T15802 | 27813-27819 | Protein | denotes | SIGIRR |
T15801 | 27727-27730 | Protein | denotes | TLR |
T15800 | 27717-27722 | Protein | denotes | IL-1R |
T15799 | 27553-27562 | Negative_regulation | denotes | inhibitor |
T15798 | 27553-27562 | Negative_regulation | denotes | inhibitor |
T15797 | 27616-27627 | Binding | denotes | interaction |
T15796 | 27616-27627 | Binding | denotes | interaction |
T15795 | 27666-27671 | Protein | denotes | TRAF6 |
T15794 | 27657-27662 | Protein | denotes | IRAK1 |
T15793 | 27650-27655 | Protein | denotes | MyD88 |
T15792 | 27576-27579 | Protein | denotes | TLR |
T15791 | 27566-27571 | Protein | denotes | IL-1R |
T15790 | 27490-27506 | Protein | denotes | TLR/IL-1R family |
T15789 | 27464-27469 | Protein | denotes | TIR-8 |
T15788 | 27388-27423 | Protein | denotes | Single-immunoglobulin IL-1 receptor |
T15787 | 27336-27371 | Protein | denotes | Single-immunoglobulin IL-1 receptor |
T15167 | 27244-27248 | Protein | denotes | CYLD |
T15166 | 27148-27153 | Protein | denotes | NF-κB |
T15165 | 27135-27139 | Protein | denotes | RANK |
T15164 | 26964-26974 | Gene_expression | denotes | expressing |
T15163 | 26993-26996 | Protein | denotes | p62 |
T15162 | 26730-26739 | Negative_regulation | denotes | recruited |
T15161 | 26658-26669 | Positive_regulation | denotes | upregulated |
T15160 | 26635-26645 | Gene_expression | denotes | expression |
T15159 | 26896-26901 | Protein | denotes | TRAF6 |
T15158 | 26805-26808 | Protein | denotes | p62 |
T15157 | 26771-26780 | Protein | denotes | ubiquitin |
T15156 | 26743-26762 | Protein | denotes | ubiquitinated TRAF6 |
T15155 | 26690-26695 | Protein | denotes | RANKL |
T15154 | 26630-26634 | Protein | denotes | CYLD |
T15153 | 26559-26564 | Protein | denotes | RANKL |
T15152 | 26406-26416 | Negative_regulation | denotes | deficiency |
T15151 | 26420-26424 | Protein | denotes | CYLD |
T15150 | 26324-26332 | Regulation | denotes | regulate |
T15149 | 26333-26337 | Protein | denotes | RANK |
T15148 | 26290-26294 | Protein | denotes | CYLD |
T15147 | 26091-26100 | Regulation | denotes | regulates |
T15146 | 26117-26122 | Protein | denotes | NF-κB |
T15145 | 25956-25963 | Regulation | denotes | control |
T15144 | 25970-25980 | Positive_regulation | denotes | activation |
T15143 | 25964-25969 | Protein | denotes | NF-κB |
T15142 | 25948-25952 | Protein | denotes | CYLD |
T15141 | 25628-25637 | Regulation | denotes | regulates |
T15140 | 25628-25637 | Regulation | denotes | regulates |
T15139 | 25628-25637 | Regulation | denotes | regulates |
T15138 | 25628-25637 | Regulation | denotes | regulates |
T15137 | 25628-25637 | Regulation | denotes | regulates |
T15136 | 25628-25637 | Regulation | denotes | regulates |
T15135 | 25628-25637 | Regulation | denotes | regulates |
T15134 | 25745-25762 | Gene_expression | denotes | deubiquitina-ting |
T15133 | 25745-25762 | Gene_expression | denotes | deubiquitina-ting |
T15132 | 25745-25762 | Gene_expression | denotes | deubiquitina-ting |
T15131 | 25745-25762 | Gene_expression | denotes | deubiquitina-ting |
T15130 | 25745-25762 | Gene_expression | denotes | deubiquitina-ting |
T15129 | 25745-25762 | Gene_expression | denotes | deubiquitina-ting |
T15128 | 25745-25762 | Gene_expression | denotes | deubiquitina-ting |
T15127 | 25843-25847 | Protein | denotes | TAK1 |
T15126 | 25834-25838 | Protein | denotes | RIP1 |
T15125 | 25827-25832 | Protein | denotes | TRAF7 |
T15124 | 25820-25825 | Protein | denotes | TRAF6 |
T15123 | 25813-25818 | Protein | denotes | TRAF2 |
T15122 | 25807-25811 | Protein | denotes | NEMO |
T15121 | 25771-25796 | Protein | denotes | NF-κB signalling proteins |
T15120 | 25683-25698 | Protein | denotes | T-cell receptor |
T15119 | 25674-25678 | Protein | denotes | RANK |
T15118 | 25668-25672 | Protein | denotes | TNFR |
T15117 | 25638-25643 | Protein | denotes | NF-κB |
T15116 | 25578-25582 | Protein | denotes | CYLD |
T15115 | 25385-25389 | Protein | denotes | CYLD |
T13777 | 23387-23391 | Protein | denotes | ABIN |
T13776 | 23383-23386 | Protein | denotes | A20 |
T13775 | 23329-23334 | Protein | denotes | NF-κB |
T13774 | 23152-23157 | Protein | denotes | ABINs |
T13773 | 23052-23059 | Negative_regulation | denotes | inhibit |
T13772 | 23066-23076 | Positive_regulation | denotes | activation |
T13771 | 22999-23008 | Gene_expression | denotes | expressed |
T13770 | 23080-23083 | Protein | denotes | TNF |
T13769 | 23060-23065 | Protein | denotes | NF-κB |
T13768 | 23009-23033 | Protein | denotes | A20 interacting proteins |
T13767 | 22959-22965 | Protein | denotes | TNIP-3 |
T13766 | 22947-22953 | Protein | denotes | TNIP-2 |
T13765 | 22939-22945 | Protein | denotes | TNIP-1 |
T13764 | 22878-22888 | Negative_regulation | denotes | inhibitors |
T13763 | 22892-22897 | Protein | denotes | NF-κB |
T13802 | 24600-24610 | Negative_regulation | denotes | suppressed |
T13801 | 24582-24586 | Protein | denotes | ITAM |
T13800 | 24468-24474 | Regulation | denotes | depend |
T13799 | 24468-24474 | Regulation | denotes | depend |
T13798 | 24468-24474 | Regulation | denotes | depend |
T13797 | 24482-24492 | Gene_expression | denotes | expression |
T13796 | 24482-24492 | Gene_expression | denotes | expression |
T13795 | 24482-24492 | Gene_expression | denotes | expression |
T13794 | 24352-24362 | Negative_regulation | denotes | inhibition |
T13793 | 24537-24540 | Protein | denotes | A20 |
T13792 | 24517-24532 | Protein | denotes | proteins ABIN-3 |
T13791 | 24500-24505 | Protein | denotes | NF-κB |
T13790 | 24366-24369 | Protein | denotes | TLR |
T13789 | 24126-24132 | Positive_regulation | denotes | levels |
T13788 | 24283-24288 | Protein | denotes | NF-κB |
T13787 | 24136-24147 | Protein | denotes | ABIN-1 mRNA |
T13786 | 24076-24079 | Protein | denotes | TNF |
T13785 | 23962-23965 | Protein | denotes | TNF |
T13784 | 23883-23886 | Protein | denotes | TNF |
T13783 | 23810-23819 | Protein | denotes | ubiquitin |
T13782 | 23641-23646 | Protein | denotes | NF-κB |
T13781 | 23580-23585 | Protein | denotes | NF-κB |
T13780 | 23370-23374 | Positive_regulation | denotes | role |
T13779 | 23370-23374 | Positive_regulation | denotes | role |
T13778 | 23439-23444 | Protein | denotes | NF-κB |
T12010 | 22791-22799 | Protein | denotes | A20 SNPs |
T12009 | 22507-22519 | Protein | denotes | A20 promoter |
T12008 | 22176-22179 | Protein | denotes | TNF |
T12007 | 22151-22154 | Protein | denotes | TNF |
T12006 | 22116-22119 | Protein | denotes | A20 |
T12005 | 21828-21837 | Protein | denotes | A20 locus |
T12004 | 21601-21616 | Protein | denotes | human A20 locus |
T12003 | 21166-21180 | Positive_regulation | denotes | overexpression |
T12002 | 21166-21180 | Gene_expression | denotes | overexpression |
T12001 | 21162-21165 | Protein | denotes | A20 |
T12000 | 20970-20979 | Negative_regulation | denotes | decreased |
T11999 | 20970-20979 | Negative_regulation | denotes | decreased |
T11998 | 21004-21009 | Protein | denotes | IL-1β |
T11997 | 20996-20999 | Protein | denotes | TNF |
T11996 | 20869-20874 | Protein | denotes | IL-1β |
T11995 | 20861-20864 | Protein | denotes | TNF |
T11994 | 20553-20563 | Negative_regulation | denotes | inhibition |
T11993 | 20553-20563 | Negative_regulation | denotes | inhibition |
T11992 | 20553-20563 | Negative_regulation | denotes | inhibition |
T11991 | 20553-20563 | Negative_regulation | denotes | inhibition |
T11990 | 20553-20563 | Negative_regulation | denotes | inhibition |
T11989 | 20586-20595 | Negative_regulation | denotes | decreased |
T11988 | 20586-20595 | Negative_regulation | denotes | decreased |
T11987 | 20586-20595 | Negative_regulation | denotes | decreased |
T11986 | 20586-20595 | Negative_regulation | denotes | decreased |
T11985 | 20586-20595 | Negative_regulation | denotes | decreased |
T11984 | 20503-20513 | Gene_expression | denotes | expression |
T11983 | 20814-20820 | Protein | denotes | NF- κB |
T11982 | 20793-20798 | Protein | denotes | NF-κB |
T11981 | 20738-20746 | Protein | denotes | collagen |
T11980 | 20680-20685 | Protein | denotes | IL-17 |
T11979 | 20632-20637 | Protein | denotes | RANKL |
T11978 | 20618-20622 | Protein | denotes | IL-6 |
T11977 | 20611-20616 | Protein | denotes | IL-1β |
T11976 | 20606-20609 | Protein | denotes | TNF |
T11975 | 20567-20572 | Protein | denotes | NF-κB |
T11974 | 20499-20502 | Protein | denotes | A20 |
T11973 | 20275-20285 | Gene_expression | denotes | expressing |
T11972 | 20397-20405 | Protein | denotes | collagen |
T11971 | 20271-20274 | Protein | denotes | A20 |
T11970 | 20131-20140 | Regulation | denotes | regulated |
T11969 | 20110-20120 | Gene_expression | denotes | expression |
T11968 | 20211-20216 | Protein | denotes | NF-κB |
T11967 | 20144-20149 | Protein | denotes | NF-κB |
T11966 | 20106-20109 | Protein | denotes | A20 |
T11965 | 19933-19943 | Gene_expression | denotes | expression |
T11964 | 19929-19932 | Protein | denotes | A20 |
T11963 | 19853-19858 | Protein | denotes | NF-κB |
T11962 | 19643-19646 | Protein | denotes | TNF |
T11961 | 19360-19363 | Protein | denotes | TNF |
T11960 | 18934-18945 | Negative_regulation | denotes | suppressing |
T11959 | 18952-18962 | Positive_regulation | denotes | activation |
T11958 | 18964-18967 | Protein | denotes | A20 |
T11957 | 18946-18951 | Protein | denotes | NF-κB |
T11956 | 18850-18859 | Negative_regulation | denotes | inhibitor |
T11955 | 18850-18859 | Negative_regulation | denotes | inhibitor |
T11954 | 18738-18749 | Binding | denotes | association |
T11953 | 18882-18904 | Protein | denotes | Tax1-binding protein 1 |
T11952 | 18863-18877 | Protein | denotes | NF-κB (ABIN) 1 |
T11951 | 18753-18756 | Protein | denotes | A20 |
T11950 | 18698-18710 | Negative_regulation | denotes | downregulate |
T11949 | 18711-18716 | Protein | denotes | NF-κB |
T11948 | 18628-18635 | Protein | denotes | cIAP1/2 |
T11947 | 18618-18623 | Protein | denotes | TRAF2 |
T11946 | 18611-18616 | Protein | denotes | TRAF6 |
T11945 | 18589-18609 | Protein | denotes | E3 ubiquitin ligases |
T11944 | 18577-18583 | Protein | denotes | Ubc5hc |
T11943 | 18567-18572 | Protein | denotes | Ubc13 |
T11942 | 18533-18545 | Protein | denotes | E2 ubiquitin |
T11941 | 18451-18463 | Binding | denotes | interactions |
T11940 | 18320-18336 | Positive_regulation | denotes | deubiquitinating |
T11939 | 18320-18336 | Positive_regulation | denotes | deubiquitinating |
T11938 | 18320-18336 | Positive_regulation | denotes | deubiquitinating |
T11937 | 18320-18336 | Positive_regulation | denotes | deubiquitinating |
T11936 | 18320-18336 | Positive_regulation | denotes | deubiquitinating |
T11935 | 18294-18301 | Negative_regulation | denotes | inhibit |
T11934 | 18404-18409 | Protein | denotes | MALT1 |
T11933 | 18394-18399 | Protein | denotes | TRAF6 |
T11932 | 18388-18392 | Protein | denotes | RIP2 |
T11931 | 18382-18386 | Protein | denotes | RIP1 |
T11930 | 18346-18351 | Protein | denotes | NF-κB |
T11929 | 18302-18307 | Protein | denotes | NF-κB |
T11928 | 18275-18278 | Protein | denotes | A20 |
T11927 | 18137-18141 | Protein | denotes | IL-1 |
T11926 | 18132-18135 | Protein | denotes | TNF |
T11925 | 18038-18043 | Protein | denotes | NF-κB |
T11924 | 17996-18003 | Protein | denotes | editing |
T11923 | 17986-17995 | Protein | denotes | ubiquitin |
T11922 | 17972-17979 | Protein | denotes | TNFAIP3 |
T11921 | 17953-17956 | Protein | denotes | A20 |
T11920 | 17941-17952 | Protein | denotes | A20 protein |
T9228 | 17665-17679 | Phosphorylation | denotes | phosphorylates |
T9227 | 17665-17679 | Phosphorylation | denotes | phosphorylates |
T9226 | 17855-17860 | Protein | denotes | NF-κB |
T9225 | 17781-17785 | Protein | denotes | IKK1 |
T9224 | 17736-17741 | Protein | denotes | NF-κB |
T9223 | 17680-17683 | Protein | denotes | NIK |
T9222 | 17660-17664 | Protein | denotes | IKK1 |
T9221 | 17508-17515 | Negative_regulation | denotes | inhibit |
T9220 | 17580-17595 | Phosphorylation | denotes | phosphorylating |
T9219 | 17596-17601 | Protein | denotes | STAT1 |
T9218 | 17516-17529 | Protein | denotes | nuclear NF-κB |
T9217 | 17480-17484 | Protein | denotes | IKK1 |
T9216 | 17302-17311 | Negative_regulation | denotes | deficient |
T9215 | 17428-17436 | Positive_regulation | denotes | enhanced |
T9214 | 17428-17436 | Positive_regulation | denotes | enhanced |
T9213 | 17333-17343 | Gene_expression | denotes | expressing |
T9212 | 17302-17311 | Negative_regulation | denotes | deficient |
T9211 | 17457-17478 | Protein | denotes | IκBα degradation [34] |
T9210 | 17437-17441 | Protein | denotes | IKK2 |
T9209 | 17353-17357 | Protein | denotes | IKK1 |
T9208 | 17297-17301 | Protein | denotes | IKK1 |
T9207 | 17264-17269 | Protein | denotes | NF-κB |
T9206 | 17119-17124 | Protein | denotes | NF-κB |
T9205 | 17069-17073 | Protein | denotes | IKK1 |
T9204 | 16903-16909 | Protein | denotes | IRAK-M |
T9203 | 16895-16901 | Protein | denotes | MyD88s |
T9202 | 16847-16852 | Protein | denotes | NF-κB |
T9201 | 16716-16720 | Regulation | denotes | role |
T9200 | 16730-16735 | Protein | denotes | NF-κB |
T9199 | 16620-16625 | Protein | denotes | NF-κB |
T9198 | 16570-16575 | Protein | denotes | NF-κB |
T9197 | 16427-16439 | Negative_regulation | denotes | downregulate |
T9196 | 16440-16445 | Protein | denotes | NF-κB |
T9195 | 16251-16261 | Positive_regulation | denotes | activation |
T9194 | 16245-16250 | Protein | denotes | NF-κB |
T9193 | 16195-16200 | Protein | denotes | NF-κB |
T9192 | 16035-16045 | Regulation | denotes | regulation |
T9191 | 15974-15984 | Positive_regulation | denotes | activation |
T9190 | 16053-16058 | Protein | denotes | NF-κB |
T9189 | 15968-15973 | Protein | denotes | NF-κB |
T7585 | 15812-15820 | Positive_regulation | denotes | required |
T7584 | 15765-15775 | Positive_regulation | denotes | activation |
T7583 | 15752-15760 | Positive_regulation | denotes | mediated |
T7582 | 15734-15742 | Positive_regulation | denotes | required |
T7581 | 15734-15742 | Positive_regulation | denotes | required |
T7580 | 15825-15835 | Positive_regulation | denotes | activation |
T7579 | 15785-15795 | Gene_expression | denotes | production |
T7578 | 15765-15775 | Positive_regulation | denotes | activation |
T7577 | 15890-15894 | Protein | denotes | CD40 |
T7576 | 15850-15855 | Protein | denotes | TRAF3 |
T7575 | 15839-15844 | Protein | denotes | NF-κB |
T7574 | 15803-15808 | Protein | denotes | TRAF2 |
T7573 | 15780-15784 | Protein | denotes | IL-6 |
T7572 | 15761-15764 | Protein | denotes | JNK |
T7571 | 15747-15751 | Protein | denotes | CD40 |
T7570 | 15635-15645 | Binding | denotes | associated |
T7569 | 15676-15680 | Protein | denotes | CD40 |
T7568 | 15616-15630 | Protein | denotes | TRAF molecules |
T7567 | 15456-15461 | Positive_regulation | denotes | leads |
T7566 | 15456-15461 | Positive_regulation | denotes | leads |
T7565 | 15469-15480 | Protein_catabolism | denotes | proteolysis |
T7564 | 15469-15480 | Protein_catabolism | denotes | proteolysis |
T7534 | 13803-13818 | Phosphorylation | denotes | phosphorylation |
T7533 | 13781-13793 | Positive_regulation | denotes | accumulation |
T7532 | 13798-13802 | Protein | denotes | IKK1 |
T7531 | 13777-13780 | Protein | denotes | NIK |
T7530 | 13678-13689 | Protein_catabolism | denotes | degradation |
T7529 | 13678-13689 | Protein_catabolism | denotes | degradation |
T7528 | 13533-13539 | Negative_regulation | denotes | remove |
T7527 | 13628-13635 | Protein | denotes | cIAP1/2 |
T7526 | 13618-13623 | Protein | denotes | TRAF2 |
T7525 | 13540-13545 | Protein | denotes | TRAF3 |
T7524 | 13431-13438 | Positive_regulation | denotes | leading |
T7523 | 13457-13468 | Protein_catabolism | denotes | degradation |
T7522 | 13358-13365 | Binding | denotes | complex |
T7521 | 13358-13365 | Binding | denotes | complex |
T7520 | 13358-13365 | Binding | denotes | complex |
T7519 | 13389-13396 | Protein | denotes | cIAP1/2 |
T7518 | 13378-13383 | Protein | denotes | TRAF3 |
T7517 | 13371-13376 | Protein | denotes | TRAF2 |
T7516 | 13330-13333 | Protein | denotes | NIK |
T7515 | 13122-13131 | Positive_regulation | denotes | activated |
T7514 | 13122-13131 | Positive_regulation | denotes | activated |
T7513 | 13122-13131 | Positive_regulation | denotes | activated |
T7512 | 13122-13131 | Positive_regulation | denotes | activated |
T7511 | 13137-13152 | Phosphorylation | denotes | phosphorylation |
T7510 | 13137-13152 | Phosphorylation | denotes | phosphorylation |
T7509 | 13122-13131 | Positive_regulation | denotes | activated |
T7508 | 13094-13103 | Positive_regulation | denotes | dependent |
T7507 | 13179-13182 | Protein | denotes | NIK |
T7506 | 13156-13177 | Protein | denotes | NF-κB inducing kinase |
T7505 | 13107-13111 | Protein | denotes | IKK1 |
T7504 | 13068-13073 | Protein | denotes | NF-κB |
T7503 | 12900-12902 | Protein | denotes | κB |
T7502 | 12892-12899 | Protein | denotes | RelB NF |
T7501 | 12863-12866 | Protein | denotes | p52 |
T7500 | 12824-12828 | Protein | denotes | p100 |
T7499 | 12790-12794 | Protein | denotes | RANK |
T7498 | 12780-12784 | Protein | denotes | CD40 |
T7497 | 12765-12778 | Protein | denotes | BAFF receptor |
T7496 | 12741-12763 | Protein | denotes | lymphotoxin β receptor |
T7495 | 12703-12708 | Protein | denotes | NF-κB |
T7494 | 12588-12596 | Positive_regulation | denotes | activate |
T7493 | 12588-12596 | Positive_regulation | denotes | activate |
T7492 | 12662-12665 | Protein | denotes | TNF |
T7491 | 12606-12609 | Protein | denotes | IKK |
T7490 | 12597-12601 | Protein | denotes | TAK1 |
T7489 | 12509-12517 | Negative_regulation | denotes | recruits |
T7488 | 12509-12517 | Negative_regulation | denotes | recruits |
T7487 | 12533-12537 | Protein | denotes | RIP1 |
T7486 | 12518-12523 | Protein | denotes | TRAF6 |
T7485 | 12499-12503 | Protein | denotes | TRIF |
T7484 | 12445-12460 | Binding | denotes | oligomerisation |
T7483 | 12361-12369 | Binding | denotes | recruits |
T7482 | 12361-12369 | Binding | denotes | recruits |
T7481 | 12487-12492 | Protein | denotes | TRAF6 |
T7480 | 12427-12432 | Protein | denotes | TRAF6 |
T7479 | 12410-12414 | Protein | denotes | IRAK |
T7478 | 12385-12408 | Protein | denotes | IL-1R-associated kinase |
T7477 | 12347-12352 | Protein | denotes | MyD88 |
T7476 | 12033-12040 | Positive_regulation | denotes | induces |
T7475 | 12212-12219 | Binding | denotes | recruit |
T7474 | 12212-12219 | Binding | denotes | recruit |
T7473 | 12212-12219 | Binding | denotes | recruit |
T7472 | 12212-12219 | Binding | denotes | recruit |
T7471 | 12212-12219 | Binding | denotes | recruit |
T7470 | 12045-12056 | Binding | denotes | recruitment |
T7469 | 11999-12010 | Positive_regulation | denotes | stimulation |
T7468 | 12220-12268 | Protein | denotes | myeloid differentiation primary response gene 88 |
T7467 | 12326-12330 | Protein | denotes | TRIF |
T7466 | 12320-12324 | Protein | denotes | IFNβ |
T7465 | 12281-12284 | Protein | denotes | TIR |
T7464 | 12270-12275 | Protein | denotes | MyD88 |
T7463 | 12125-12129 | Protein | denotes | TRIF |
T7462 | 12116-12119 | Protein | denotes | Mal |
T7461 | 12060-12094 | Protein | denotes | Toll/IL-1 receptor adaptor protein |
T7460 | 11994-11998 | Protein | denotes | TLR4 |
T7459 | 11893-11901 | Positive_regulation | denotes | activate |
T7458 | 11906-11910 | Protein | denotes | TAK1 |
T7457 | 11859-11872 | Protein | denotes | polyubiquitin |
T7456 | 11776-11789 | Protein | denotes | polyubiquitin |
T7455 | 11684-11693 | Positive_regulation | denotes | activated |
T7454 | 11694-11699 | Protein | denotes | NF-κB |
T7453 | 11680-11683 | Protein | denotes | TNF |
T7452 | 11589-11591 | Protein | denotes | E3 |
T7451 | 11586-11588 | Protein | denotes | E2 |
T7450 | 11524-11530 | Protein | denotes | TAB1/2 |
T7449 | 11515-11519 | Protein | denotes | NEMO |
T7448 | 11488-11497 | Protein | denotes | ubiquitin |
T7447 | 11467-11471 | Protein | denotes | TAK1 |
T7446 | 11459-11462 | Protein | denotes | IKK |
T7445 | 11405-11409 | Protein | denotes | RIP1 |
T7444 | 11381-11394 | Protein | denotes | polyubiquitin |
T7443 | 11308-11312 | Protein | denotes | RIP1 |
T7442 | 11276-11283 | Protein | denotes | cIAP1/2 |
T7441 | 11264-11271 | Protein | denotes | TRAF2/5 |
T7440 | 11171-11182 | Positive_regulation | denotes | stimulation |
T7439 | 11242-11255 | Protein | denotes | polyubiquitin |
T7438 | 11203-11207 | Protein | denotes | RIP1 |
T7437 | 11184-11196 | Protein | denotes | TNF-receptor |
T7436 | 11167-11170 | Protein | denotes | TNF |
T7435 | 11019-11029 | Binding | denotes | associated |
T7434 | 11019-11029 | Binding | denotes | associated |
T7433 | 10826-10837 | Binding | denotes | recruitment |
T7432 | 10826-10837 | Binding | denotes | recruitment |
T7431 | 10826-10837 | Binding | denotes | recruitment |
T7430 | 10826-10837 | Binding | denotes | recruitment |
T7429 | 10826-10837 | Binding | denotes | recruitment |
T7428 | 10826-10837 | Binding | denotes | recruitment |
T7427 | 11083-11100 | Protein | denotes | ubiquitin ligases |
T7426 | 11080-11082 | Protein | denotes | E3 |
T7425 | 11050-11055 | Protein | denotes | TRAF5 |
T7424 | 11006-11018 | Protein | denotes | TNF receptor |
T7423 | 10985-10997 | Protein | denotes | E3 ubiquitin |
T7422 | 10935-10939 | Protein | denotes | RIP1 |
T7421 | 10903-10933 | Protein | denotes | receptor interacting protein 1 |
T7420 | 10881-10886 | Protein | denotes | TRADD |
T7419 | 10841-10879 | Protein | denotes | TNF receptor-1-associated death domain |
T7418 | 10795-10798 | Protein | denotes | TNF |
T7417 | 10782-10785 | Protein | denotes | TNF |
T7416 | 10749-10754 | Protein | denotes | NF-κB |
T7415 | 8484-8492 | Positive_regulation | denotes | required |
T7414 | 8484-8492 | Positive_regulation | denotes | required |
T7413 | 8484-8492 | Positive_regulation | denotes | required |
T7412 | 8513-8523 | Positive_regulation | denotes | activation |
T7411 | 8507-8512 | Protein | denotes | NF-κB |
T7410 | 8474-8478 | Protein | denotes | IKK1 |
T7409 | 8460-8464 | Protein | denotes | NEMO |
T7408 | 8451-8455 | Protein | denotes | IKK2 |
T7407 | 8235-8244 | Gene_expression | denotes | comprised |
T7406 | 8235-8244 | Gene_expression | denotes | comprised |
T7405 | 8235-8244 | Gene_expression | denotes | comprised |
T7404 | 8338-8351 | Protein | denotes | subunit NF-κB |
T7403 | 8313-8317 | Protein | denotes | IKKβ |
T7402 | 8304-8308 | Protein | denotes | IKKα |
T7401 | 8284-8288 | Protein | denotes | IKK2 |
T7400 | 8275-8279 | Protein | denotes | IKK1 |
T7399 | 8220-8231 | Protein | denotes | IKK complex |
T7398 | 8083-8091 | Positive_regulation | denotes | mediates |
T7397 | 8083-8091 | Positive_regulation | denotes | mediates |
T7396 | 8083-8091 | Positive_regulation | denotes | mediates |
T7395 | 8033-8043 | Positive_regulation | denotes | activation |
T7394 | 8033-8043 | Positive_regulation | denotes | activation |
T7393 | 8180-8191 | Protein_catabolism | denotes | degradation |
T7392 | 8180-8191 | Protein_catabolism | denotes | degradation |
T7391 | 8092-8107 | Phosphorylation | denotes | phosphorylation |
T7390 | 8068-8075 | Entity | denotes | complex |
T7389 | 8126-8137 | Protein | denotes | IκB protein |
T7388 | 8063-8066 | Protein | denotes | IKK |
T7387 | 8051-8061 | Protein | denotes | IκB kinase |
T7386 | 7854-7859 | Protein | denotes | NF-κB |
T7385 | 7841-7844 | Protein | denotes | TLR |
T7384 | 7830-7835 | Protein | denotes | RANKL |
T7383 | 7808-7811 | Protein | denotes | TNF |
T7382 | 7659-7664 | Protein | denotes | NF-κB |
T7381 | 7632-7634 | Protein | denotes | κB |
T7380 | 7536-7541 | Protein | denotes | NF-κB |
T7379 | 7481-7499 | Protein | denotes | p50 NF-κB subunits |
T7378 | 7473-7476 | Protein | denotes | p52 |
T7377 | 7446-7450 | Protein | denotes | p105 |
T7376 | 7437-7441 | Protein | denotes | p100 |
T7375 | 7344-7354 | Negative_regulation | denotes | inhibitors |
T7374 | 7344-7354 | Negative_regulation | denotes | inhibitors |
T7373 | 7405-7420 | Positive_regulation | denotes | transactivation |
T7372 | 7405-7420 | Positive_regulation | denotes | transactivation |
T7371 | 7344-7354 | Negative_regulation | denotes | inhibitors |
T7370 | 7388-7404 | Protein | denotes | potentiate NF-κB |
T7369 | 7374-7379 | Protein | denotes | Bcl-3 |
T7368 | 7365-7369 | Protein | denotes | IκBξ |
T7563 | 15362-15370 | Binding | denotes | interact |
T7562 | 15362-15370 | Binding | denotes | interact |
T7561 | 15323-15330 | Binding | denotes | binding |
T7560 | 15323-15330 | Binding | denotes | binding |
T7559 | 15323-15330 | Binding | denotes | binding |
T7558 | 15323-15330 | Binding | denotes | binding |
T7557 | 15323-15330 | Binding | denotes | binding |
T7556 | 15323-15330 | Binding | denotes | binding |
T7555 | 15323-15330 | Binding | denotes | binding |
T7554 | 15323-15330 | Binding | denotes | binding |
T7553 | 15323-15330 | Binding | denotes | binding |
T7552 | 15323-15330 | Binding | denotes | binding |
T7551 | 15323-15330 | Binding | denotes | binding |
T7550 | 15499-15504 | Protein | denotes | TRAF3 |
T7549 | 15489-15494 | Protein | denotes | TRAF2 |
T7548 | 15440-15445 | Protein | denotes | TRAF6 |
T7547 | 15429-15434 | Protein | denotes | TRAF5 |
T7546 | 15422-15427 | Protein | denotes | TRAF3 |
T7545 | 15415-15420 | Protein | denotes | TRAF2 |
T7544 | 15408-15413 | Protein | denotes | TRAF1 |
T7543 | 15357-15361 | Protein | denotes | RANK |
T7542 | 15348-15352 | Protein | denotes | CD40 |
T7541 | 15291-15296 | Protein | denotes | NF-κB |
T7540 | 15228-15232 | Protein | denotes | RANK |
T7539 | 15201-15223 | Protein | denotes | lymphotoxin β receptor |
T7538 | 15195-15199 | Protein | denotes | CD40 |
T7537 | 13781-13793 | Positive_regulation | denotes | accumulation |
T7536 | 13764-13773 | Positive_regulation | denotes | resulting |
T7535 | 13764-13773 | Positive_regulation | denotes | resulting |
T3444 | 4765-4775 | Gene_expression | denotes | expression |
T3443 | 4836-4840 | Protein | denotes | BAFF |
T3442 | 4783-4834 | Protein | denotes | TNF receptor family member B-cell activating factor |
T3441 | 4576-4588 | Protein | denotes | CD40 signals |
T3440 | 4527-4548 | Protein | denotes | anti-CD154 antibodies |
T3439 | 4519-4523 | Protein | denotes | CD40 |
T3438 | 4331-4341 | Positive_regulation | denotes | activation |
T3437 | 4331-4341 | Positive_regulation | denotes | activation |
T3436 | 4264-4273 | Gene_expression | denotes | expressed |
T3435 | 4264-4273 | Gene_expression | denotes | expressed |
T3359 | 4207-4214 | Binding | denotes | Binding |
T3358 | 4328-4330 | Protein | denotes | κB |
T3357 | 4325-4327 | Protein | denotes | NF |
T3356 | 4302-4306 | Protein | denotes | CD4+ |
T3355 | 4235-4240 | Protein | denotes | CD154 |
T3354 | 4222-4233 | Protein | denotes | CD40 ligand |
T3353 | 4146-4157 | Positive_regulation | denotes | upregulated |
T3352 | 4146-4157 | Positive_regulation | denotes | upregulated |
T3351 | 4146-4157 | Positive_regulation | denotes | upregulated |
T3350 | 3967-3976 | Gene_expression | denotes | expressed |
T3349 | 3967-3976 | Gene_expression | denotes | expressed |
T3348 | 3919-3945 | Protein | denotes | TNF receptor family member |
T3347 | 3903-3907 | Protein | denotes | CD40 |
T1341 | 1823-1831 | Regulation | denotes | regulate |
T1340 | 1823-1831 | Regulation | denotes | regulate |
T1313 | 1901-1918 | Protein | denotes | cyclo-oxygenase-2 |
T1312 | 1895-1899 | Protein | denotes | IL-6 |
T1311 | 1889-1893 | Protein | denotes | IL-1 |
T1310 | 1884-1887 | Protein | denotes | TNF |
T1309 | 1758-1763 | Protein | denotes | c-Rel |
T1308 | 1752-1756 | Protein | denotes | RelB |
T1307 | 1746-1750 | Protein | denotes | RelA |
T1306 | 1739-1742 | Protein | denotes | p65 |
T1305 | 1731-1737 | Protein | denotes | NF-κB1 |
T1304 | 1723-1727 | Protein | denotes | p105 |
T1303 | 1715-1721 | Protein | denotes | NF-κB2 |
T1302 | 1707-1711 | Protein | denotes | p100 |
T213 | 9-19 | Regulation | denotes | regulation |
T214 | 37-48 | Regulation | denotes | involvement |
T1301 | 1618-1623 | Protein | denotes | NF-κB |
T1300 | 1508-1513 | Protein | denotes | NF-κB |
T215 | 87-113 | Protein | denotes | transcription factor NF-κB |
T216 | 207-212 | Protein | denotes | NF-κB |
T217 | 369-374 | Protein | denotes | NF-κB |
T218 | 475-480 | Protein | denotes | NF-κB |
T219 | 580-585 | Protein | denotes | NF-κB |
T220 | 572-579 | Regulation | denotes | control |
T211 | 23-28 | Protein | denotes | NF-κB |
T212 | 0-8 | Gene_expression | denotes | Negative |
T1339 | 1823-1831 | Regulation | denotes | regulate |
T1338 | 1823-1831 | Regulation | denotes | regulate |
T1337 | 1823-1831 | Regulation | denotes | regulate |
T1336 | 1823-1831 | Regulation | denotes | regulate |
T1335 | 1823-1831 | Regulation | denotes | regulate |
T1334 | 1823-1831 | Regulation | denotes | regulate |
T1333 | 1823-1831 | Regulation | denotes | regulate |
T1332 | 1823-1831 | Regulation | denotes | regulate |
T1331 | 1823-1831 | Regulation | denotes | regulate |
T1330 | 1823-1831 | Regulation | denotes | regulate |
T1329 | 1823-1831 | Regulation | denotes | regulate |
T1328 | 1823-1831 | Regulation | denotes | regulate |
T1327 | 1823-1831 | Regulation | denotes | regulate |
T1326 | 1823-1831 | Regulation | denotes | regulate |
T1325 | 1823-1831 | Regulation | denotes | regulate |
T1324 | 1823-1831 | Regulation | denotes | regulate |
T1323 | 1823-1831 | Regulation | denotes | regulate |
T1322 | 1932-1941 | Positive_regulation | denotes | inducible |
T1321 | 1836-1846 | Gene_expression | denotes | expression |
T1320 | 1836-1846 | Gene_expression | denotes | expression |
T1319 | 1836-1846 | Gene_expression | denotes | expression |
T1318 | 1836-1846 | Gene_expression | denotes | expression |
T1317 | 1836-1846 | Gene_expression | denotes | expression |
T1316 | 1836-1846 | Gene_expression | denotes | expression |
T1315 | 1976-1994 | Protein | denotes | metalloproteinases |
T1314 | 1942-1963 | Protein | denotes | nitric oxide synthase |
T1349 | 1823-1831 | Regulation | denotes | regulate |
T1348 | 1823-1831 | Regulation | denotes | regulate |
T1347 | 1823-1831 | Regulation | denotes | regulate |
T1346 | 1823-1831 | Regulation | denotes | regulate |
T1345 | 1823-1831 | Regulation | denotes | regulate |
T1344 | 1823-1831 | Regulation | denotes | regulate |
T1343 | 1823-1831 | Regulation | denotes | regulate |
T1342 | 1823-1831 | Regulation | denotes | regulate |
T1365 | 2300-2305 | Protein | denotes | NF-κB |
T1364 | 2116-2121 | Protein | denotes | NF-κB |
T1363 | 2075-2085 | Positive_regulation | denotes | activators |
T1362 | 2075-2085 | Positive_regulation | denotes | activators |
T1361 | 2089-2094 | Protein | denotes | NF-κB |
T1360 | 2043-2047 | Protein | denotes | IL-1 |
T1359 | 2035-2038 | Protein | denotes | TNF |
T1358 | 1823-1831 | Regulation | denotes | regulate |
T1357 | 1823-1831 | Regulation | denotes | regulate |
T1356 | 1823-1831 | Regulation | denotes | regulate |
T1355 | 1823-1831 | Regulation | denotes | regulate |
T1354 | 1823-1831 | Regulation | denotes | regulate |
T1353 | 1823-1831 | Regulation | denotes | regulate |
T1352 | 1823-1831 | Regulation | denotes | regulate |
T1351 | 1823-1831 | Regulation | denotes | regulate |
T1350 | 1823-1831 | Regulation | denotes | regulate |
T1367 | 2385-2390 | Protein | denotes | NF-κB |
T1366 | 2122-2132 | Positive_regulation | denotes | activation |
T3343 | 3702-3728 | Protein | denotes | TNF receptor family member |
T3342 | 3693-3697 | Protein | denotes | RANK |
T3341 | 3686-3691 | Protein | denotes | NF-κB |
T3340 | 3644-3649 | Protein | denotes | NF-κB |
T3339 | 3568-3576 | Positive_regulation | denotes | mediates |
T3338 | 3538-3548 | Positive_regulation | denotes | activation |
T3337 | 3532-3537 | Protein | denotes | NF-κB |
T3336 | 3498-3503 | Protein | denotes | NF-κB |
T3335 | 3458-3462 | Protein | denotes | IL-1 |
T3334 | 3450-3453 | Protein | denotes | TNF |
T3333 | 3375-3378 | Protein | denotes | TNF |
T3332 | 3324-3328 | Protein | denotes | IL-1 |
T3331 | 3316-3319 | Protein | denotes | TNF |
T3330 | 3235-3243 | Positive_regulation | denotes | activate |
T3329 | 3244-3249 | Protein | denotes | NF-κB |
T3328 | 3105-3110 | Protein | denotes | NF-κB |
T3346 | 3650-3660 | Positive_regulation | denotes | activation |
T3345 | 3650-3660 | Positive_regulation | denotes | activation |
T3344 | 3789-3799 | Protein | denotes | RANK-NF-κB |
T1381 | 3015-3025 | Positive_regulation | denotes | activation |
T1380 | 3009-3014 | Protein | denotes | NF-κB |
T1379 | 2953-2960 | Protein | denotes | TNFAIP3 |
T1378 | 2946-2951 | Protein | denotes | TRAF1 |
T1377 | 2940-2944 | Protein | denotes | CD40 |
T1376 | 2912-2917 | Protein | denotes | NF-κB |
T1375 | 2663-2672 | Positive_regulation | denotes | activator |
T1374 | 2663-2672 | Positive_regulation | denotes | activator |
T1373 | 2690-2695 | Protein | denotes | RANKL |
T1372 | 2676-2688 | Protein | denotes | NF-κB ligand |
T1371 | 2571-2576 | Protein | denotes | NF-κB |
T1370 | 2447-2455 | Negative_regulation | denotes | blockade |
T1369 | 2391-2401 | Positive_regulation | denotes | activation |
T1368 | 2459-2464 | Protein | denotes | NF-κB |
T3434 | 4207-4214 | Binding | denotes | Binding |
T18605 | 30979-30984 | Protein | denotes | NF-κB |
T18604 | 30894-30902 | Protein | denotes | miR-146a |
T18603 | 30853-30858 | Protein | denotes | TRAF6 |
T18602 | 30843-30848 | Protein | denotes | IRAK1 |
T18601 | 30816-30821 | Protein | denotes | NF-κB |
T18600 | 30786-30791 | Protein | denotes | NF-κB |
T18599 | 30771-30779 | Protein | denotes | miR-146a |
T18598 | 30736-30739 | Protein | denotes | TNF |
T18597 | 30729-30734 | Protein | denotes | IL-1β |
T18596 | 30656-30661 | Protein | denotes | NF-κB |
T18595 | 30590-30597 | Protein | denotes | miR-155 |
T18594 | 30575-30585 | Protein | denotes | miR-146a/b |
T3472 | 6915-6925 | Positive_regulation | denotes | contribute |
T3471 | 6935-6945 | Positive_regulation | denotes | activation |
T3470 | 6929-6934 | Protein | denotes | NF-κB |
T3469 | 6759-6769 | Protein | denotes | tenascin C |
T3468 | 6736-6747 | Protein | denotes | fibronectin |
T3467 | 6724-6734 | Protein | denotes | fibrinogen |
T3466 | 6565-6569 | Protein | denotes | TLR4 |
T3465 | 6432-6443 | Protein | denotes | S100 family |
T3464 | 6147-6156 | Positive_regulation | denotes | increased |
T3463 | 6270-6278 | Protein | denotes | collagen |
T3462 | 6248-6253 | Protein | denotes | HMGB1 |
T3461 | 6233-6244 | Protein | denotes | BoxA domain |
T3460 | 6183-6212 | Protein | denotes | HMGB1 neutralising antibodies |
T3459 | 6138-6143 | Protein | denotes | HMGB1 |
T3458 | 6032-6040 | Localization | denotes | released |
T3457 | 6032-6040 | Localization | denotes | released |
T3456 | 5995-6003 | Localization | denotes | secreted |
T3455 | 5995-6003 | Localization | denotes | secreted |
T3454 | 6099-6103 | Protein | denotes | TLR4 |
T3453 | 5927-5932 | Protein | denotes | HMGB1 |
T3452 | 5880-5925 | Protein | denotes | High mobility group box chromosomal protein 1 |
T3451 | 5760-5765 | Negative_regulation | denotes | block |
T3450 | 5766-5769 | Protein | denotes | TLR |
T3449 | 5280-5285 | Protein | denotes | NF-κB |
T3448 | 5011-5033 | Protein | denotes | lymphotoxin β receptor |
T3447 | 4756-4764 | Positive_regulation | denotes | Enhanced |
T3446 | 4756-4764 | Positive_regulation | denotes | Enhanced |
T3445 | 4765-4775 | Gene_expression | denotes | expression |
T7367 | 7358-7363 | Protein | denotes | NF-κB |
T7366 | 7326-7332 | Protein | denotes | NF-κB2 |
T7365 | 7306-7310 | Protein | denotes | p100 |
T7364 | 7297-7303 | Protein | denotes | NF-κB1 |
T7363 | 7277-7281 | Protein | denotes | p105 |
T7362 | 7171-7178 | Negative_regulation | denotes | prevent |
T7361 | 7171-7178 | Negative_regulation | denotes | prevent |
T7360 | 7193-7206 | Localization | denotes | translocation |
T7359 | 7185-7192 | Entity | denotes | nuclear |
T7358 | 7130-7139 | Negative_regulation | denotes | inhibitor |
T7357 | 7130-7139 | Negative_regulation | denotes | inhibitor |
T7356 | 7179-7184 | Protein | denotes | NF-κB |
T7355 | 7150-7153 | Protein | denotes | IκB |
T7354 | 7143-7148 | Protein | denotes | NF-κB |
T7353 | 7024-7038 | Protein | denotes | NF-κB proteins |
T22265 | 14194-14197 | Protein | denotes | NIK |
T22264 | 14102-14109 | Protein | denotes | cIAP1/2 |
T22263 | 14092-14097 | Protein | denotes | TRAF3 |
T22262 | 14085-14090 | Protein | denotes | TRAF2 |
T22261 | 14067-14076 | Protein | denotes | ubiquitin |
T22260 | 13946-13955 | Positive_regulation | denotes | dependent |
T22259 | 13946-13955 | Positive_regulation | denotes | dependent |
T22258 | 13987-13997 | Gene_expression | denotes | expression |
T22257 | 13987-13997 | Gene_expression | denotes | expression |
T22256 | 13982-13985 | Protein | denotes | NIK |
T22255 | 13959-13980 | Protein | denotes | NF-κB inducing kinase |
T22254 | 13924-13929 | Protein | denotes | NF-κB |
T22253 | 13889-13893 | Protein | denotes | RANK |
T22252 | 13880-13884 | Protein | denotes | CD40 |
T22251 | 13862-13867 | Protein | denotes | NF-κB |
T17143 | 30171-30182 | Binding | denotes | association |
T17142 | 30190-30195 | Protein | denotes | TRAF1 |
T17141 | 30057-30062 | Protein | denotes | TRAF1 |
T17140 | 29955-29989 | Protein | denotes | TRAF1-complement component 5 locus |
T17139 | 29761-29769 | Binding | denotes | interact |
T17138 | 29708-29713 | Protein | denotes | TRAF1 |
T17137 | 29639-29646 | Binding | denotes | binding |
T17136 | 29639-29646 | Binding | denotes | binding |
T17135 | 29615-29619 | Protein | denotes | TRAF |
T17134 | 29595-29600 | Protein | denotes | TRAF1 |
T17133 | 29534-29543 | Regulation | denotes | modulates |
T17132 | 29551-29561 | Positive_regulation | denotes | activation |
T17131 | 29544-29550 | Protein | denotes | NF- κB |
T17130 | 29528-29533 | Protein | denotes | TRAF1 |
T17129 | 29336-29345 | Negative_regulation | denotes | deficient |
T17128 | 29426-29431 | Protein | denotes | TRAF2 |
T17127 | 29330-29335 | Protein | denotes | TRAF1 |
T17126 | 29312-29317 | Protein | denotes | NF-κB |
T17125 | 29299-29303 | Protein | denotes | CD40 |
T17124 | 29251-29256 | Protein | denotes | TRAF1 |
T17123 | 29128-29137 | Negative_regulation | denotes | deficient |
T17122 | 29225-29230 | Protein | denotes | NF-κB |
T17121 | 29170-29173 | Protein | denotes | TNF |
T17120 | 29122-29127 | Protein | denotes | TRAF1 |
T22286 | 14649-14664 | Phosphorylation | denotes | phosphorylation |
T22285 | 14607-14616 | Positive_regulation | denotes | activates |
T22284 | 14588-14602 | Phosphorylation | denotes | phosphorylates |
T22283 | 14644-14648 | Protein | denotes | p100 |
T22282 | 14638-14643 | Protein | denotes | NF-κB |
T22281 | 14617-14621 | Protein | denotes | IKK1 |
T22280 | 14579-14582 | Protein | denotes | NIK |
T22279 | 14545-14554 | Positive_regulation | denotes | increased |
T22278 | 14500-14508 | Protein_catabolism | denotes | degraded |
T22298 | 14956-14987 | Protein | denotes | TNF receptor-associated factors |
T22297 | 14846-14851 | Protein | denotes | TRAF1 |
T22296 | 14839-14844 | Protein | denotes | TRAF3 |
T22295 | 14782-14793 | Binding | denotes | heterodimer |
T22294 | 14740-14751 | Protein_catabolism | denotes | degradation |
T22293 | 14740-14751 | Protein_catabolism | denotes | degradation |
T22292 | 14799-14803 | Protein | denotes | RelB |
T22291 | 14763-14766 | Protein | denotes | p52 |
T22290 | 14755-14759 | Protein | denotes | p100 |
T22289 | 14629-14637 | Positive_regulation | denotes | mediates |
T22288 | 14629-14637 | Positive_regulation | denotes | mediates |
T22287 | 14649-14664 | Phosphorylation | denotes | phosphorylation |
T20802 | 8861-8865 | Protein | denotes | RIP1 |
T20801 | 8844-8848 | Protein | denotes | TRIF |
T20800 | 8838-8842 | Protein | denotes | IFNβ |
T20799 | 8799-8802 | Protein | denotes | TIR |
T20798 | 8794-8797 | Protein | denotes | MAL |
T20797 | 8787-8792 | Protein | denotes | MyD88 |
T20796 | 8779-8784 | Protein | denotes | TRADD |
T20795 | 8731-8777 | Protein | denotes | TNF receptor 1-associated death domain protein |
T20794 | 8672-8676 | Protein | denotes | TLR4 |
T20793 | 8662-8666 | Protein | denotes | RANK |
T20792 | 8656-8660 | Protein | denotes | CD40 |
T20791 | 8649-8654 | Protein | denotes | TNFR1 |
T20790 | 8550-8555 | Protein | denotes | NF-κB |
R202 | T211 | T212 | themeOf | NF-κB,Negative |
R203 | T212 | T213 | themeOf | Negative,regulation |
R204 | T213 | T214 | themeOf | regulation,involvement |
R205 | T219 | T220 | themeOf | NF-κB,control |
R1057 | T1310 | T1316 | themeOf | TNF,expression |
R1060 | T1311 | T1317 | themeOf | IL-1,expression |
R1061 | T1312 | T1318 | themeOf | IL-6,expression |
R1062 | T1313 | T1319 | themeOf | cyclo-oxygenase-2,expression |
R1063 | T1314 | T1320 | themeOf | nitric oxide synthase,expression |
R1065 | T1314 | T1322 | themeOf | nitric oxide synthase,inducible |
R1066 | T1315 | T1321 | themeOf | metalloproteinases,expression |
R1067 | T1316 | T1323 | themeOf | expression,regulate |
R1068 | T1316 | T1329 | themeOf | expression,regulate |
R1069 | T1316 | T1335 | themeOf | expression,regulate |
R1070 | T1316 | T1341 | themeOf | expression,regulate |
R1071 | T1316 | T1347 | themeOf | expression,regulate |
R1072 | T1342 | T1304 | Cause | regulate,p105 |
R1073 | T1316 | T1353 | themeOf | expression,regulate |
R1074 | T1317 | T1324 | themeOf | expression,regulate |
R1075 | T1343 | T1304 | Cause | regulate,p105 |
R1076 | T1344 | T1304 | Cause | regulate,p105 |
R1077 | T1345 | T1304 | Cause | regulate,p105 |
R1078 | T1346 | T1304 | Cause | regulate,p105 |
R1079 | T1347 | T1305 | Cause | regulate,NF-κB1 |
R1080 | T1348 | T1305 | Cause | regulate,NF-κB1 |
R1081 | T1349 | T1305 | Cause | regulate,NF-κB1 |
R1082 | T1317 | T1330 | themeOf | expression,regulate |
R1083 | T1350 | T1305 | Cause | regulate,NF-κB1 |
R1084 | T1351 | T1305 | Cause | regulate,NF-κB1 |
R1085 | T1352 | T1305 | Cause | regulate,NF-κB1 |
R1086 | T1353 | T1307 | Cause | regulate,RelA |
R1087 | T1354 | T1307 | Cause | regulate,RelA |
R1088 | T1355 | T1307 | Cause | regulate,RelA |
R1089 | T1356 | T1307 | Cause | regulate,RelA |
R1090 | T1357 | T1307 | Cause | regulate,RelA |
R1091 | T1358 | T1307 | Cause | regulate,RelA |
R1092 | T1361 | T1362 | themeOf | NF-κB,activators |
R1093 | T1361 | T1363 | themeOf | NF-κB,activators |
R1094 | T1362 | T1359 | Cause | activators,TNF |
R1095 | T1363 | T1360 | Cause | activators,IL-1 |
R1096 | T1364 | T1366 | themeOf | NF-κB,activation |
R1097 | T1367 | T1369 | themeOf | NF-κB,activation |
R1098 | T1317 | T1336 | themeOf | expression,regulate |
R1099 | T1368 | T1370 | themeOf | NF-κB,blockade |
R1100 | T1317 | T1342 | themeOf | expression,regulate |
R1101 | T1317 | T1348 | themeOf | expression,regulate |
R1102 | T1317 | T1354 | themeOf | expression,regulate |
R1103 | T1318 | T1325 | themeOf | expression,regulate |
R1104 | T1372 | T1374 | themeOf | NF-κB ligand,activator |
R1105 | T1373 | T1375 | themeOf | RANKL,activator |
R1106 | T1380 | T1381 | themeOf | NF-κB,activation |
R1107 | T1318 | T1331 | themeOf | expression,regulate |
R1108 | T1318 | T1337 | themeOf | expression,regulate |
R1109 | T1318 | T1343 | themeOf | expression,regulate |
R1110 | T1318 | T1349 | themeOf | expression,regulate |
R1111 | T1318 | T1355 | themeOf | expression,regulate |
R1112 | T1319 | T1326 | themeOf | expression,regulate |
R1127 | T1319 | T1332 | themeOf | expression,regulate |
R1128 | T1319 | T1338 | themeOf | expression,regulate |
R1129 | T1319 | T1344 | themeOf | expression,regulate |
R1130 | T1319 | T1350 | themeOf | expression,regulate |
R1131 | T1319 | T1356 | themeOf | expression,regulate |
R1132 | T1320 | T1327 | themeOf | expression,regulate |
R1133 | T1320 | T1333 | themeOf | expression,regulate |
R1134 | T1320 | T1339 | themeOf | expression,regulate |
R1135 | T1320 | T1345 | themeOf | expression,regulate |
R1136 | T1320 | T1351 | themeOf | expression,regulate |
R1137 | T1320 | T1357 | themeOf | expression,regulate |
R1138 | T1321 | T1328 | themeOf | expression,regulate |
R1139 | T1321 | T1334 | themeOf | expression,regulate |
R1140 | T1321 | T1340 | themeOf | expression,regulate |
R1141 | T1321 | T1346 | themeOf | expression,regulate |
R1142 | T1321 | T1352 | themeOf | expression,regulate |
R1143 | T1321 | T1358 | themeOf | expression,regulate |
R1144 | T1323 | T1301 | Cause | regulate,NF-κB |
R1145 | T1324 | T1301 | Cause | regulate,NF-κB |
R1146 | T1325 | T1301 | Cause | regulate,NF-κB |
R1147 | T1326 | T1301 | Cause | regulate,NF-κB |
R1149 | T1327 | T1301 | Cause | regulate,NF-κB |
R1150 | T1328 | T1301 | Cause | regulate,NF-κB |
R1151 | T1329 | T1302 | Cause | regulate,p100 |
R1152 | T1330 | T1302 | Cause | regulate,p100 |
R1153 | T1331 | T1302 | Cause | regulate,p100 |
R1154 | T1332 | T1302 | Cause | regulate,p100 |
R1155 | T1333 | T1302 | Cause | regulate,p100 |
R1156 | T1334 | T1302 | Cause | regulate,p100 |
R1157 | T1335 | T1303 | Cause | regulate,NF-κB2 |
R1158 | T1336 | T1303 | Cause | regulate,NF-κB2 |
R1159 | T1337 | T1303 | Cause | regulate,NF-κB2 |
R1160 | T1338 | T1303 | Cause | regulate,NF-κB2 |
R1162 | T1339 | T1303 | Cause | regulate,NF-κB2 |
R1166 | T1340 | T1303 | Cause | regulate,NF-κB2 |
R1171 | T1341 | T1304 | Cause | regulate,p105 |
R2648 | T3329 | T3330 | themeOf | NF-κB,activate |
R2652 | T3337 | T3338 | themeOf | NF-κB,activation |
R2654 | T3338 | T3339 | themeOf | activation,mediates |
R2656 | T3340 | T3345 | themeOf | NF-κB,activation |
R2658 | T3343 | T3346 | themeOf | TNF receptor family member,activation |
R2662 | T3347 | T3349 | themeOf | CD40,expressed |
R2663 | T3347 | T3351 | themeOf | CD40,upregulated |
R2664 | T3348 | T3350 | themeOf | TNF receptor family member,expressed |
R2666 | T3349 | T3352 | themeOf | expressed,upregulated |
R2667 | T3350 | T3353 | themeOf | expressed,upregulated |
R2670 | T3354 | T3359 | themeOf | CD40 ligand,Binding |
R2671 | T3354 | T3435 | themeOf | CD40 ligand,expressed |
R2672 | T3355 | T3434 | themeOf | CD154,Binding |
R2673 | T3355 | T3436 | themeOf | CD154,expressed |
R2675 | T3357 | T3437 | themeOf | NF,activation |
R2676 | T3358 | T3438 | themeOf | κB,activation |
R2707 | T3445 | T3447 | themeOf | expression,Enhanced |
R2708 | T3450 | T3451 | themeOf | TLR,block |
R2709 | T3442 | T3444 | themeOf | TNF receptor family member B-cell activating factor,expression |
R2710 | T3443 | T3445 | themeOf | BAFF,expression |
R2711 | T3444 | T3446 | themeOf | expression,Enhanced |
R2712 | T3452 | T3455 | themeOf | High mobility group box chromosomal protein 1,secreted |
R2713 | T3452 | T3457 | themeOf | High mobility group box chromosomal protein 1,released |
R2714 | T3453 | T3456 | themeOf | HMGB1,secreted |
R2715 | T3453 | T3458 | themeOf | HMGB1,released |
R2716 | T3459 | T3464 | themeOf | HMGB1,increased |
R2718 | T3470 | T3471 | themeOf | NF-κB,activation |
R2726 | T3471 | T3472 | themeOf | activation,contribute |
R5116 | T7354 | T7357 | themeOf | NF-κB,inhibitor |
R5117 | T7355 | T7358 | themeOf | IκB,inhibitor |
R5119 | T7356 | T7360 | themeOf | NF-κB,translocation |
R5120 | T7360 | T7359 | ToLoc | translocation,nuclear |
R5122 | T7360 | T7361 | themeOf | translocation,prevent |
R5123 | T7360 | T7362 | themeOf | translocation,prevent |
R5124 | T7361 | T7357 | Cause | prevent,inhibitor |
R5125 | T7362 | T7358 | Cause | prevent,inhibitor |
R5128 | T7367 | T7371 | themeOf | NF-κB,inhibitors |
R5130 | T7370 | T7372 | themeOf | potentiate NF-κB,transactivation |
R5131 | T7370 | T7373 | themeOf | potentiate NF-κB,transactivation |
R5132 | T7372 | T7368 | Cause | transactivation,IκBξ |
R5134 | T7372 | T7374 | themeOf | transactivation,inhibitors |
R5137 | T7373 | T7369 | Cause | transactivation,Bcl-3 |
R5138 | T7373 | T7375 | themeOf | transactivation,inhibitors |
R5141 | T7387 | T7394 | themeOf | IκB kinase,activation |
R5144 | T7388 | T7392 | themeOf | IKK,degradation |
R5145 | T7388 | T7395 | themeOf | IKK,activation |
R5146 | T7389 | T7391 | themeOf | IκB protein,phosphorylation |
R5148 | T7389 | T7393 | themeOf | IκB protein,degradation |
R5149 | T7390 | T7387 | SiteParent | complex,IκB kinase |
R5153 | T7390 | T7388 | SiteParent | complex,IKK |
R5154 | T7391 | T7396 | themeOf | phosphorylation,mediates |
R5155 | T7392 | T7397 | themeOf | degradation,mediates |
R5158 | T7393 | T7398 | themeOf | degradation,mediates |
R5160 | T7394 | T7390 | Site | activation,complex |
R5161 | T7395 | T7390 | Site | activation,complex |
R5163 | T7396 | T7388 | Cause | mediates,IKK |
R5168 | T7397 | T7388 | Cause | mediates,IKK |
R5171 | T7398 | T7388 | Cause | mediates,IKK |
R5172 | T7399 | T7405 | themeOf | IKK complex,comprised |
R5173 | T7400 | T7406 | themeOf | IKK1,comprised |
R5174 | T7401 | T7407 | themeOf | IKK2,comprised |
R5175 | T7411 | T7412 | themeOf | NF-κB,activation |
R5176 | T7412 | T7413 | themeOf | activation,required |
R5177 | T7486 | T7488 | themeOf | TRAF6,recruits |
R5178 | T7412 | T7414 | themeOf | activation,required |
R5179 | T7487 | T7489 | themeOf | RIP1,recruits |
R5180 | T7412 | T7415 | themeOf | activation,required |
R5181 | T7488 | T7485 | Cause | recruits,TRIF |
R5182 | T7413 | T7408 | Cause | required,IKK2 |
R5183 | T7489 | T7485 | Cause | recruits,TRIF |
R5184 | T7490 | T7493 | themeOf | TAK1,activate |
R5185 | T7491 | T7494 | themeOf | IKK,activate |
R5186 | T7414 | T7409 | Cause | required,NEMO |
R5187 | T7415 | T7410 | Cause | required,IKK1 |
R5188 | T7419 | T7431 | themeOf | TNF receptor-1-associated death domain,recruitment |
R5189 | T7420 | T7428 | themeOf | TRADD,recruitment |
R5190 | T7505 | T7508 | themeOf | IKK1,dependent |
R5191 | T7505 | T7509 | themeOf | IKK1,activated |
R5192 | T7505 | T7510 | themeOf | IKK1,phosphorylation |
R5193 | T7420 | T7432 | themeOf | TRADD,recruitment |
R5194 | T7507 | T7511 | themeOf | NIK,phosphorylation |
R5195 | T7420 | T7433 | themeOf | TRADD,recruitment |
R5196 | T7421 | T7429 | themeOf | receptor interacting protein 1,recruitment |
R5197 | T7509 | T7507 | Cause | activated,NIK |
R5198 | T7510 | T7512 | themeOf | phosphorylation,activated |
R5199 | T7510 | T7514 | themeOf | phosphorylation,activated |
R5200 | T7511 | T7513 | themeOf | phosphorylation,activated |
R5201 | T7511 | T7515 | themeOf | phosphorylation,activated |
R5202 | T7421 | T7432 | themeOf | receptor interacting protein 1,recruitment |
R5203 | T7512 | T7506 | Cause | activated,NF-κB inducing kinase |
R5204 | T7422 | T7430 | themeOf | RIP1,recruitment |
R5205 | T7513 | T7506 | Cause | activated,NF-κB inducing kinase |
R5206 | T7514 | T7507 | Cause | activated,NIK |
R5207 | T7515 | T7507 | Cause | activated,NIK |
R5208 | T7516 | T7520 | themeOf | NIK,complex |
R5209 | T7516 | T7521 | themeOf | NIK,complex |
R5210 | T7516 | T7522 | themeOf | NIK,complex |
R5211 | T7516 | T7523 | themeOf | NIK,degradation |
R5212 | T7517 | T7520 | themeOf | TRAF2,complex |
R5213 | T7518 | T7521 | themeOf | TRAF3,complex |
R5214 | T7519 | T7522 | themeOf | cIAP1/2,complex |
R5215 | T7422 | T7431 | themeOf | RIP1,recruitment |
R5216 | T7422 | T7433 | themeOf | RIP1,recruitment |
R5217 | T7422 | T7434 | themeOf | RIP1,associated |
R5218 | T7523 | T7524 | themeOf | degradation,leading |
R5219 | T7424 | T7434 | themeOf | TNF receptor,associated |
R5220 | T7525 | T7528 | themeOf | TRAF3,remove |
R5221 | T7424 | T7435 | themeOf | TNF receptor,associated |
R5222 | T7526 | T7529 | themeOf | TRAF2,degradation |
R5223 | T7425 | T7435 | themeOf | TRAF5,associated |
R5224 | T7527 | T7530 | themeOf | cIAP1/2,degradation |
R5225 | T7436 | T7440 | themeOf | TNF,stimulation |
R5226 | T7531 | T7533 | themeOf | NIK,accumulation |
R5227 | T7532 | T7534 | themeOf | IKK1,phosphorylation |
R5228 | T7533 | T7535 | themeOf | accumulation,resulting |
R5229 | T7534 | T7536 | themeOf | phosphorylation,resulting |
R5230 | T7534 | T7537 | themeOf | phosphorylation,accumulation |
R5231 | T7542 | T7554 | themeOf | CD40,binding |
R5232 | T7542 | T7555 | themeOf | CD40,binding |
R5233 | T7542 | T7556 | themeOf | CD40,binding |
R5234 | T7542 | T7562 | themeOf | CD40,interact |
R5235 | T7542 | T7563 | themeOf | CD40,interact |
R5236 | T7543 | T7557 | themeOf | RANK,binding |
R5237 | T7543 | T7558 | themeOf | RANK,binding |
R5238 | T7543 | T7559 | themeOf | RANK,binding |
R5239 | T7454 | T7455 | themeOf | NF-κB,activated |
R5240 | T7546 | T7551 | themeOf | TRAF3,binding |
R5241 | T7546 | T7554 | themeOf | TRAF3,binding |
R5242 | T7546 | T7557 | themeOf | TRAF3,binding |
R5243 | T7546 | T7560 | themeOf | TRAF3,binding |
R5244 | T7547 | T7552 | themeOf | TRAF5,binding |
R5245 | T7547 | T7555 | themeOf | TRAF5,binding |
R5246 | T7547 | T7558 | themeOf | TRAF5,binding |
R5247 | T7547 | T7561 | themeOf | TRAF5,binding |
R5248 | T7547 | T7562 | themeOf | TRAF5,interact |
R5249 | T7548 | T7553 | themeOf | TRAF6,binding |
R5250 | T7548 | T7556 | themeOf | TRAF6,binding |
R5251 | T7548 | T7559 | themeOf | TRAF6,binding |
R5252 | T7548 | T7560 | themeOf | TRAF6,binding |
R5253 | T7548 | T7561 | themeOf | TRAF6,binding |
R5254 | T7548 | T7563 | themeOf | TRAF6,interact |
R5255 | T7549 | T7564 | themeOf | TRAF2,proteolysis |
R5256 | T7550 | T7565 | themeOf | TRAF3,proteolysis |
R5257 | T7564 | T7566 | themeOf | proteolysis,leads |
R5258 | T7565 | T7567 | themeOf | proteolysis,leads |
R5259 | T7568 | T7570 | themeOf | TRAF molecules,associated |
R5260 | T7455 | T7453 | Cause | activated,TNF |
R5261 | T7458 | T7459 | themeOf | TAK1,activate |
R5262 | T7572 | T7578 | themeOf | JNK,activation |
R5263 | T7573 | T7579 | themeOf | IL-6,production |
R5264 | T7460 | T7469 | themeOf | TLR4,stimulation |
R5265 | T7575 | T7580 | themeOf | NF-κB,activation |
R5266 | T7461 | T7470 | themeOf | Toll/IL-1 receptor adaptor protein,recruitment |
R5267 | T7578 | T7581 | themeOf | activation,required |
R5268 | T7578 | T7583 | themeOf | activation,mediated |
R5269 | T7579 | T7582 | themeOf | production,required |
R5270 | T7579 | T7584 | themeOf | production,activation |
R5271 | T7464 | T7471 | themeOf | MyD88,recruit |
R5272 | T7580 | T7585 | themeOf | activation,required |
R5273 | T7465 | T7472 | themeOf | TIR,recruit |
R5274 | T7583 | T7571 | Cause | mediated,CD40 |
R5275 | T7465 | T7475 | themeOf | TIR,recruit |
R5276 | T7585 | T7574 | Cause | required,TRAF2 |
R5277 | T7466 | T7473 | themeOf | IFNβ,recruit |
R5278 | T7467 | T7474 | themeOf | TRIF,recruit |
R5279 | T7467 | T7475 | themeOf | TRIF,recruit |
R5280 | T7470 | T7476 | themeOf | recruitment,induces |
R5281 | T7476 | T7469 | Cause | induces,stimulation |
R5284 | T7477 | T7482 | themeOf | MyD88,recruits |
R5285 | T7477 | T7483 | themeOf | MyD88,recruits |
R5286 | T7479 | T7482 | themeOf | IRAK,recruits |
R5289 | T7480 | T7483 | themeOf | TRAF6,recruits |
R5291 | T7481 | T7484 | themeOf | TRAF6,oligomerisation |
R6275 | T9189 | T9191 | themeOf | NF-κB,activation |
R6276 | T9191 | T9192 | themeOf | activation,regulation |
R6277 | T9194 | T9195 | themeOf | NF-κB,activation |
R6278 | T9196 | T9197 | themeOf | NF-κB,downregulate |
R6279 | T9200 | T9201 | themeOf | NF-κB,role |
R6280 | T9208 | T9212 | themeOf | IKK1,deficient |
R6281 | T9209 | T9213 | themeOf | IKK1,expressing |
R6282 | T9210 | T9214 | themeOf | IKK2,enhanced |
R6283 | T9211 | T9215 | themeOf | IκBα degradation [34],enhanced |
R6284 | T9213 | T9216 | themeOf | expressing,deficient |
R6285 | T9218 | T9221 | themeOf | nuclear NF-κB,inhibit |
R6286 | T9219 | T9220 | themeOf | STAT1,phosphorylating |
R6287 | T9221 | T9220 | Cause | inhibit,phosphorylating |
R6288 | T9222 | T9227 | themeOf | IKK1,phosphorylates |
R6289 | T9223 | T9228 | themeOf | NIK,phosphorylates |
R8131 | T11929 | T11935 | themeOf | NF-κB,inhibit |
R8133 | T11930 | T11936 | themeOf | NF-κB,deubiquitinating |
R8134 | T11931 | T11937 | themeOf | RIP1,deubiquitinating |
R8135 | T11931 | T11941 | themeOf | RIP1,interactions |
R8136 | T11932 | T11938 | themeOf | RIP2,deubiquitinating |
R8138 | T11933 | T11939 | themeOf | TRAF6,deubiquitinating |
R8139 | T11934 | T11940 | themeOf | MALT1,deubiquitinating |
R8140 | T11935 | T11928 | Cause | inhibit,A20 |
R8141 | T11949 | T11950 | themeOf | NF-κB,downregulate |
R8142 | T11951 | T11954 | themeOf | A20,association |
R8143 | T11952 | T11955 | themeOf | NF-κB (ABIN) 1,inhibitor |
R8144 | T11953 | T11956 | themeOf | Tax1-binding protein 1,inhibitor |
R8145 | T11957 | T11959 | themeOf | NF-κB,activation |
R8146 | T11959 | T11960 | themeOf | activation,suppressing |
R8147 | T11964 | T11965 | themeOf | A20,expression |
R8149 | T11966 | T11969 | themeOf | A20,expression |
R8151 | T11969 | T11970 | themeOf | expression,regulated |
R8156 | T11970 | T11967 | Cause | regulated,NF-κB |
R8157 | T11971 | T11973 | themeOf | A20,expressing |
R8158 | T11974 | T11984 | themeOf | A20,expression |
R8160 | T11976 | T11985 | themeOf | TNF,decreased |
R8164 | T11977 | T11986 | themeOf | IL-1β,decreased |
R8166 | T11978 | T11987 | themeOf | IL-6,decreased |
R8168 | T11979 | T11988 | themeOf | RANKL,decreased |
R8169 | T11980 | T11989 | themeOf | IL-17,decreased |
R8172 | T11985 | T11990 | themeOf | decreased,inhibition |
R8176 | T11986 | T11991 | themeOf | decreased,inhibition |
R8178 | T11987 | T11992 | themeOf | decreased,inhibition |
R8179 | T11988 | T11993 | themeOf | decreased,inhibition |
R8180 | T11989 | T11994 | themeOf | decreased,inhibition |
R8181 | T11997 | T11999 | themeOf | TNF,decreased |
R8185 | T11998 | T12000 | themeOf | IL-1β,decreased |
R8187 | T12001 | T12002 | themeOf | A20,overexpression |
R8188 | T12002 | T12003 | themeOf | overexpression,overexpression |
R9222 | T13763 | T13764 | themeOf | NF-κB,inhibitors |
R9223 | T13768 | T13771 | themeOf | A20 interacting proteins,expressed |
R9224 | T13769 | T13772 | themeOf | NF-κB,activation |
R9225 | T13772 | T13773 | themeOf | activation,inhibit |
R9226 | T13773 | T13770 | Cause | inhibit,TNF |
R9227 | T13776 | T13779 | themeOf | A20,role |
R9228 | T13777 | T13780 | themeOf | ABIN,role |
R9229 | T13787 | T13789 | themeOf | ABIN-1 mRNA,levels |
R9230 | T13790 | T13794 | themeOf | TLR,inhibition |
R9231 | T13791 | T13795 | themeOf | NF-κB,expression |
R9232 | T13792 | T13796 | themeOf | proteins ABIN-3,expression |
R9233 | T13793 | T13797 | themeOf | A20,expression |
R9234 | T13795 | T13798 | themeOf | expression,depend |
R9235 | T13796 | T13799 | themeOf | expression,depend |
R9236 | T13797 | T13800 | themeOf | expression,depend |
R9237 | T13798 | T13794 | Cause | depend,inhibition |
R9238 | T13799 | T13794 | Cause | depend,inhibition |
R9239 | T13800 | T13794 | Cause | depend,inhibition |
R9240 | T13801 | T13802 | themeOf | ITAM,suppressed |
R10062 | T15117 | T15135 | themeOf | NF-κB,regulates |
R10063 | T15117 | T15136 | themeOf | NF-κB,regulates |
R10064 | T15117 | T15137 | themeOf | NF-κB,regulates |
R10065 | T15117 | T15138 | themeOf | NF-κB,regulates |
R10066 | T15117 | T15139 | themeOf | NF-κB,regulates |
R10067 | T15117 | T15140 | themeOf | NF-κB,regulates |
R10068 | T15117 | T15141 | themeOf | NF-κB,regulates |
R10069 | T15121 | T15128 | themeOf | NF-κB signalling proteins,deubiquitina-ting |
R10070 | T15122 | T15129 | themeOf | NEMO,deubiquitina-ting |
R10071 | T15123 | T15130 | themeOf | TRAF2,deubiquitina-ting |
R10072 | T15124 | T15131 | themeOf | TRAF6,deubiquitina-ting |
R10073 | T15125 | T15132 | themeOf | TRAF7,deubiquitina-ting |
R10074 | T15126 | T15133 | themeOf | RIP1,deubiquitina-ting |
R10075 | T15127 | T15134 | themeOf | TAK1,deubiquitina-ting |
R10076 | T15135 | T15128 | Cause | regulates,deubiquitina-ting |
R10077 | T15136 | T15129 | Cause | regulates,deubiquitina-ting |
R10078 | T15137 | T15130 | Cause | regulates,deubiquitina-ting |
R10079 | T15138 | T15131 | Cause | regulates,deubiquitina-ting |
R10080 | T15139 | T15132 | Cause | regulates,deubiquitina-ting |
R10081 | T15140 | T15133 | Cause | regulates,deubiquitina-ting |
R10082 | T15141 | T15134 | Cause | regulates,deubiquitina-ting |
R10083 | T15143 | T15144 | themeOf | NF-κB,activation |
R10084 | T15144 | T15145 | themeOf | activation,control |
R10085 | T15145 | T15142 | Cause | control,CYLD |
R10086 | T15146 | T15147 | themeOf | NF-κB,regulates |
R10087 | T15149 | T15150 | themeOf | RANK,regulate |
R10088 | T15150 | T15148 | Cause | regulate,CYLD |
R10089 | T15151 | T15152 | themeOf | CYLD,deficiency |
R10090 | T15154 | T15160 | themeOf | CYLD,expression |
R10091 | T15160 | T15161 | themeOf | expression,upregulated |
R10092 | T15160 | T15162 | themeOf | expression,recruited |
R10093 | T15163 | T15164 | themeOf | p62,expressing |
R11316 | T17106 | T17107 | themeOf | ubiquitin ligase,lacks |
R11317 | T17107 | T17104 | Cause | lacks,TRAF1 |
R11318 | T17111 | T17116 | themeOf | TRAF1,Expression |
R11319 | T17113 | T17118 | themeOf | TRAF1,overexpression |
R11320 | T17116 | T17117 | themeOf | Expression,inducible |
R11321 | T17117 | T17112 | Cause | inducible,TNF |
R11322 | T17118 | T17119 | themeOf | overexpression,overexpression |
R11323 | T17120 | T17123 | themeOf | TRAF1,deficient |
R11324 | T17127 | T17129 | themeOf | TRAF1,deficient |
R11325 | T17131 | T17132 | themeOf | NF- κB,activation |
R11326 | T17132 | T17133 | themeOf | activation,modulates |
R11327 | T17133 | T17130 | Cause | modulates,TRAF1 |
R11328 | T17134 | T17136 | themeOf | TRAF1,binding |
R11329 | T17134 | T17137 | themeOf | TRAF1,binding |
R11330 | T17135 | T17137 | themeOf | TRAF,binding |
R11331 | T17138 | T17139 | themeOf | TRAF1,interact |
R11332 | T17142 | T17143 | themeOf | TRAF1,association |
R12394 | T18607 | T18605 | SiteParent | "[79,80",NF-κB |
R12395 | T18607 | T18606 | SiteParent | "[79,80",molecules IKKε and RIP1 |
R12396 | T18608 | T18610 | themeOf | miR-146,expressed |
R12397 | T18609 | T18611 | themeOf | miR-155,expressed |
R12398 | T18612 | T18614 | themeOf | miR-146a,overexpressed |
R12399 | T18613 | T18615 | themeOf | CD4+,IL-17-producing |
R12400 | T18617 | T18618 | themeOf | metalloproteinases,expression |
R12401 | T18618 | T18619 | themeOf | expression,prevent |
R12402 | T18620 | T18621 | themeOf | TNF,production |
R12403 | T18621 | T18622 | themeOf | production,promote |
R12404 | T18624 | T18626 | themeOf | miR-124a,decreased |
R12405 | T18627 | T18629 | themeOf | matrix metalloproteinase-1,secretion |
R12406 | T18628 | T18630 | themeOf | IL-6,secretion |
R12407 | T18629 | T18631 | themeOf | secretion,leading |
R12408 | T18629 | T18633 | themeOf | secretion,increased |
R12409 | T18630 | T18632 | themeOf | secretion,leading |
R12410 | T18630 | T18634 | themeOf | secretion,increased |
R12604 | T19045 | T19046 | themeOf | NF-κB,activation |
R12605 | T19047 | T19048 | themeOf | NF-κB,regulation |
R13788 | T20855 | T20857 | causeOf | inhibiting,regulate |
R13789 | T20856 | T20858 | causeOf | inhibiting,regulate |
R13790 | T20859 | T20863 | themeOf | TLR,inhibited |
R13791 | T20860 | T20864 | themeOf | TLR4,compete |
R14523 | T22255 | T22257 | themeOf | NF-κB inducing kinase,expression |
R14524 | T22256 | T22258 | themeOf | NIK,expression |
R14525 | T22257 | T22259 | themeOf | expression,dependent |
R14526 | T22258 | T22260 | themeOf | expression,dependent |
R14527 | T22265 | T22267 | themeOf | NIK,degradation |
R14528 | T22268 | T22271 | themeOf | TRAF3,binding |
R14529 | T22268 | T22272 | themeOf | TRAF3,recruited |
R14530 | T22275 | T22278 | themeOf | TRAF3,degraded |
R14531 | T22277 | T22279 | themeOf | NIK,increased |
R14532 | T22280 | T22284 | themeOf | NIK,phosphorylates |
R14533 | T22281 | T22285 | themeOf | IKK1,activates |
R14534 | T22282 | T22286 | themeOf | NF-κB,phosphorylation |
R14535 | T22283 | T22287 | themeOf | p100,phosphorylation |
R14536 | T22285 | T22280 | Cause | activates,NIK |
R14537 | T22286 | T22288 | themeOf | phosphorylation,mediates |
R14538 | T22287 | T22289 | themeOf | phosphorylation,mediates |
R14539 | T22288 | T22281 | Cause | mediates,IKK1 |
R14540 | T22289 | T22281 | Cause | mediates,IKK1 |
R14541 | T22290 | T22293 | themeOf | p100,degradation |
R14542 | T22291 | T22294 | themeOf | p52,degradation |
R14543 | T22292 | T22295 | themeOf | RelB,heterodimer |
R14544 | T22297 | T22299 | themeOf | TRAF1,competing |
R14545 | T22298 | T22299 | themeOf | TNF receptor-associated factors,competing |
R10427 | T15788 | T15796 | themeOf | Single-immunoglobulin IL-1 receptor,interaction |
R10429 | T15794 | T15796 | themeOf | IRAK1,interaction |
R10428 | T15788 | T15797 | themeOf | Single-immunoglobulin IL-1 receptor,interaction |
R10430 | T15795 | T15797 | themeOf | TRAF6,interaction |
R10431 | T15796 | T15798 | themeOf | interaction,inhibitor |
R10432 | T15797 | T15799 | themeOf | interaction,inhibitor |
R10433 | T15800 | T15803 | themeOf | IL-1R,role |
R10434 | T15801 | T15804 | themeOf | TLR,role |
R10435 | T15805 | T15806 | themeOf | SIGIRR,overexpression |
R10436 | T15806 | T15807 | themeOf | overexpression,overexpression |
R10437 | T15811 | T15812 | themeOf | SIGIRR,expression |
R13760 | T20811 | T20817 | themeOf | RIP1,polyubiquitination |
R13761 | T20812 | T20818 | themeOf | IRAK1,polyubiquitination |
R13762 | T20812 | T20819 | themeOf | IRAK1,recruitment |
R13763 | T20816 | T20819 | themeOf | TAK1,recruitment |
R13764 | T20820 | T20823 | themeOf | TAK1,phosphorylates |
R13765 | T20820 | T20824 | causeOf | TAK1,activates |
R13766 | T20821 | T20824 | themeOf | IKK2,activates |
R13767 | T20821 | T20825 | themeOf | IKK2,phosphorylates |
R13768 | T20822 | T20826 | themeOf | IκBα,phosphorylates |
R13769 | T20822 | T20827 | themeOf | IκBα,degradation |
R13770 | T20827 | T20828 | themeOf | degradation,triggering |
R13771 | T20829 | T20833 | themeOf | NF-κB,translocate |
R13772 | T20832 | T20833 | locationOf | nucleus,translocate |
R13773 | T20836 | T20838 | themeOf | NF-κB,activation |
R13774 | T20837 | T20839 | themeOf | TRAFs,competing |
R13775 | T20838 | T20840 | themeOf | activation,regulate |
R13776 | T20839 | T20840 | causeOf | competing,regulate |
R13777 | T20841 | T20848 | causeOf | A20,control |
R13778 | T20842 | T20849 | causeOf | CYLD,control |
R13779 | T20843 | T20847 | themeOf | NF-κB,activation |
R13780 | T20847 | T20848 | themeOf | activation,control |
R13781 | T20847 | T20849 | themeOf | activation,control |
R13782 | T20850 | T20857 | themeOf | TLR,regulate |
R13783 | T20850 | T20858 | themeOf | TLR,regulate |
R13784 | T20851 | T20853 | themeOf | IRAK1,expression |
R13785 | T20852 | T20854 | themeOf | TRAF6,expression |
R13786 | T20853 | T20855 | themeOf | expression,inhibiting |
R13787 | T20854 | T20856 | themeOf | expression,inhibiting |
R13792 | T20861 | T20865 | themeOf | IRAK1,binding |
R13793 | T20862 | T20866 | themeOf | TRAF6,binding |
test3
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T19395 | 8731-8777 | Protein | denotes | TNF receptor 1-associated death domain protein |
T19394 | 8689-8700 | Binding | denotes | recruitment |
T19393 | 8677-8684 | Positive_regulation | denotes | trigger |
T21400 | 15143-15165 | Protein | denotes | tumour necrosis factor |
T21399 | 15138-15141 | Protein | denotes | TNF |
T21398 | 15071-15098 | Protein | denotes | receptor activator of NF-κB |
T21397 | 15065-15069 | Protein | denotes | RANK |
T21396 | 14846-14851 | Protein | denotes | TRAF1 |
T21395 | 14839-14844 | Protein | denotes | TRAF3 |
T21394 | 14799-14803 | Protein | denotes | RelB |
T21393 | 14763-14766 | Protein | denotes | p52 |
T21392 | 14755-14759 | Protein | denotes | p100 |
T21391 | 14740-14751 | Protein_catabolism | denotes | degradation |
T21390 | 14649-14664 | Phosphorylation | denotes | phosphorylation |
T21389 | 14644-14648 | Protein | denotes | p100 |
T21388 | 14629-14637 | Positive_regulation | denotes | mediates |
T21387 | 14617-14621 | Protein | denotes | IKK1 |
T21386 | 14607-14616 | Positive_regulation | denotes | activates |
T21385 | 14579-14582 | Protein | denotes | NIK |
T21384 | 14555-14558 | Protein | denotes | NIK |
T21383 | 14513-14516 | Protein | denotes | NIK |
T21382 | 14500-14508 | Protein_catabolism | denotes | degraded |
T21381 | 14491-14496 | Protein | denotes | TRAF3 |
T21380 | 14473-14476 | Protein | denotes | NIK |
T21379 | 14454-14459 | Protein | denotes | TRAF3 |
T21378 | 14407-14408 | Protein | denotes | 2 |
T21377 | 14401-14406 | Protein | denotes | cIAP1 |
T21376 | 14354-14355 | Protein | denotes | 2 |
T21375 | 14348-14353 | Protein | denotes | cIAP1 |
T21374 | 14286-14291 | Protein | denotes | TRAF2 |
T21373 | 14253-14262 | Binding | denotes | recruited |
T21372 | 14244-14249 | Protein | denotes | TRAF3 |
T21371 | 14235-14242 | Binding | denotes | binding |
T21370 | 14207-14210 | Protein | denotes | NIK |
T21369 | 14194-14197 | Protein | denotes | NIK |
T21368 | 14179-14190 | Protein_catabolism | denotes | degradation |
T21367 | 14108-14109 | Protein | denotes | 2 |
T21366 | 14102-14107 | Protein | denotes | cIAP1 |
T21365 | 14092-14097 | Protein | denotes | TRAF3 |
T21364 | 14085-14090 | Protein | denotes | TRAF2 |
T21363 | 14028-14031 | Protein | denotes | NIK |
T21362 | 13982-13985 | Protein | denotes | NIK |
T21361 | 13959-13980 | Protein | denotes | NF-κB inducing kinase |
T21360 | 13889-13893 | Protein | denotes | RANK |
T21359 | 13880-13884 | Protein | denotes | CD40 |
T21358 | 15143-15165 | Protein | denotes | tumour necrosis factor |
T21357 | 15138-15141 | Protein | denotes | TNF |
T21356 | 15071-15098 | Protein | denotes | receptor activator of NF-κB |
T21355 | 15065-15069 | Protein | denotes | RANK |
T21354 | 14846-14851 | Protein | denotes | TRAF1 |
T21353 | 14839-14844 | Protein | denotes | TRAF3 |
T21352 | 14799-14803 | Protein | denotes | RelB |
T21351 | 14763-14766 | Protein | denotes | p52 |
T21350 | 14755-14759 | Protein | denotes | p100 |
T21349 | 14644-14648 | Protein | denotes | p100 |
T21348 | 14617-14621 | Protein | denotes | IKK1 |
T21347 | 14579-14582 | Protein | denotes | NIK |
T21346 | 14555-14558 | Protein | denotes | NIK |
T21345 | 14513-14516 | Protein | denotes | NIK |
T21344 | 14491-14496 | Protein | denotes | TRAF3 |
T21343 | 14473-14476 | Protein | denotes | NIK |
T21342 | 14454-14459 | Protein | denotes | TRAF3 |
T21341 | 14407-14408 | Protein | denotes | 2 |
T21340 | 14401-14406 | Protein | denotes | cIAP1 |
T21339 | 14354-14355 | Protein | denotes | 2 |
T21338 | 14348-14353 | Protein | denotes | cIAP1 |
T21337 | 14286-14291 | Protein | denotes | TRAF2 |
T21336 | 14244-14249 | Protein | denotes | TRAF3 |
T21335 | 14207-14210 | Protein | denotes | NIK |
T21334 | 14194-14197 | Protein | denotes | NIK |
T21333 | 14108-14109 | Protein | denotes | 2 |
T21332 | 14102-14107 | Protein | denotes | cIAP1 |
T21331 | 14092-14097 | Protein | denotes | TRAF3 |
T21330 | 14085-14090 | Protein | denotes | TRAF2 |
T21329 | 14028-14031 | Protein | denotes | NIK |
T21328 | 13982-13985 | Protein | denotes | NIK |
T21327 | 13959-13980 | Protein | denotes | NF-κB inducing kinase |
T21326 | 13889-13893 | Protein | denotes | RANK |
T21325 | 13880-13884 | Protein | denotes | CD40 |
T19459 | 10701-10723 | Protein | denotes | tumour necrosis factor |
T19458 | 10696-10699 | Protein | denotes | TNF |
T19457 | 10558-10600 | Protein | denotes | single-immunoglobulinIL-1 receptor-related |
T19456 | 10550-10556 | Protein | denotes | SIGIRR |
T19455 | 10518-10548 | Protein | denotes | receptor interacting protein 1 |
T19454 | 10512-10516 | Protein | denotes | RIP1 |
T19453 | 10483-10510 | Protein | denotes | receptor activator of NF-κB |
T19452 | 10477-10481 | Protein | denotes | RANK |
T19451 | 10430-10455 | Protein | denotes | NF-κB essential modulator |
T19450 | 10424-10428 | Protein | denotes | NEMO |
T19449 | 10374-10422 | Protein | denotes | myeloid differentiation primary response gene 88 |
T19448 | 10367-10372 | Protein | denotes | MyD88 |
T19447 | 10277-10292 | Protein | denotes | cylindromatosis |
T19446 | 10271-10275 | Protein | denotes | CYLD |
T19445 | 10200-10230 | Protein | denotes | A20-binding inhibitor of NF-κB |
T19444 | 10194-10198 | Protein | denotes | ABIN |
T19443 | 10031-10036 | Protein | denotes | TRAF6 |
T19442 | 10021-10026 | Protein | denotes | IRAK1 |
T19441 | 10010-10017 | Binding | denotes | binding |
T19440 | 10001-10005 | Protein | denotes | TLR4 |
T19439 | 9988-9995 | Negative_regulation | denotes | compete |
T19438 | 9953-9959 | Protein | denotes | SIGIRR |
T19437 | 9914-9923 | Negative_regulation | denotes | inhibited |
T19436 | 9871-9876 | Protein | denotes | TRAF6 |
T19435 | 9861-9866 | Protein | denotes | IRAK1 |
T19434 | 9847-9857 | Gene_expression | denotes | expression |
T19433 | 9836-9846 | Negative_regulation | denotes | inhibiting |
T19432 | 9771-9774 | Protein | denotes | p62 |
T19431 | 9760-9766 | Protein | denotes | ABIN-1 |
T19430 | 9727-9734 | Binding | denotes | binding |
T19429 | 9692-9701 | Binding | denotes | recruited |
T19428 | 9667-9672 | Protein | denotes | TRAF6 |
T19427 | 9658-9662 | Protein | denotes | RIP1 |
T19426 | 9542-9546 | Protein | denotes | CYLD |
T19425 | 9534-9537 | Protein | denotes | A20 |
T19424 | 9400-9405 | Protein | denotes | TRAF1 |
T19423 | 9356-9363 | Entity | denotes | nucleus |
T19422 | 9337-9348 | Localization | denotes | translocate |
T19421 | 9329-9332 | Protein | denotes | p50 |
T19420 | 9321-9324 | Protein | denotes | p65 |
T19419 | 9258-9269 | Protein_catabolism | denotes | degradation |
T19418 | 9195-9199 | Protein | denotes | IκBα |
T19417 | 9180-9194 | Phosphorylation | denotes | phosphorylates |
T19416 | 9160-9164 | Protein | denotes | IKK2 |
T19415 | 9121-9125 | Protein | denotes | TAK1 |
T19414 | 9115-9119 | Protein | denotes | TAK1 |
T19413 | 9106-9110 | Protein | denotes | IKK2 |
T19412 | 9063-9074 | Binding | denotes | recruitment |
T19411 | 9046-9055 | Positive_regulation | denotes | resulting |
T19410 | 9023-9027 | Protein | denotes | NEMO |
T19409 | 8999-9004 | Protein | denotes | IRAK1 |
T19408 | 8990-8994 | Protein | denotes | RIP1 |
T19407 | 8926-8931 | Protein | denotes | cIAP2 |
T19406 | 8919-8924 | Protein | denotes | cIAP1 |
T19405 | 8912-8917 | Protein | denotes | TRAF6 |
T19404 | 8905-8910 | Protein | denotes | TRAF2 |
T19403 | 8874-8879 | Protein | denotes | IRAK4 |
T19402 | 8867-8872 | Protein | denotes | IRAK1 |
T19401 | 8861-8865 | Protein | denotes | RIP1 |
T19400 | 8844-8848 | Protein | denotes | TRIF |
T19399 | 8799-8842 | Protein | denotes | TIR domain-containing adaptor-inducing IFNβ |
T19398 | 8794-8797 | Protein | denotes | MAL |
T19397 | 8787-8792 | Protein | denotes | MyD88 |
T19396 | 8779-8784 | Protein | denotes | TRADD |
T19392 | 8672-8676 | Protein | denotes | TLR4 |
T19391 | 8662-8666 | Protein | denotes | RANK |
T19390 | 8656-8660 | Protein | denotes | CD40 |
T19389 | 8649-8654 | Protein | denotes | TNFR1 |
T19388 | 8599-8609 | Binding | denotes | engagement |
T19387 | 10701-10723 | Protein | denotes | tumour necrosis factor |
T19386 | 10696-10699 | Protein | denotes | TNF |
T19385 | 10558-10600 | Protein | denotes | single-immunoglobulinIL-1 receptor-related |
T19384 | 10550-10556 | Protein | denotes | SIGIRR |
T19383 | 10518-10548 | Protein | denotes | receptor interacting protein 1 |
T19382 | 10512-10516 | Protein | denotes | RIP1 |
T19381 | 10483-10510 | Protein | denotes | receptor activator of NF-κB |
T19380 | 10477-10481 | Protein | denotes | RANK |
T19379 | 10430-10455 | Protein | denotes | NF-κB essential modulator |
T19378 | 10424-10428 | Protein | denotes | NEMO |
T19377 | 10374-10422 | Protein | denotes | myeloid differentiation primary response gene 88 |
T19376 | 10367-10372 | Protein | denotes | MyD88 |
T19375 | 10277-10292 | Protein | denotes | cylindromatosis |
T19374 | 10271-10275 | Protein | denotes | CYLD |
T19373 | 10200-10230 | Protein | denotes | A20-binding inhibitor of NF-κB |
T19372 | 10194-10198 | Protein | denotes | ABIN |
T19371 | 10031-10036 | Protein | denotes | TRAF6 |
T19370 | 10021-10026 | Protein | denotes | IRAK1 |
T19369 | 10001-10005 | Protein | denotes | TLR4 |
T19368 | 9953-9959 | Protein | denotes | SIGIRR |
T19367 | 9871-9876 | Protein | denotes | TRAF6 |
T19366 | 9861-9866 | Protein | denotes | IRAK1 |
T19365 | 9771-9774 | Protein | denotes | p62 |
T19364 | 9760-9766 | Protein | denotes | ABIN-1 |
T19363 | 9667-9672 | Protein | denotes | TRAF6 |
T19362 | 9658-9662 | Protein | denotes | RIP1 |
T19361 | 9542-9546 | Protein | denotes | CYLD |
T19360 | 9534-9537 | Protein | denotes | A20 |
T19359 | 9400-9405 | Protein | denotes | TRAF1 |
T19358 | 9329-9332 | Protein | denotes | p50 |
T19357 | 9321-9324 | Protein | denotes | p65 |
T19356 | 9195-9199 | Protein | denotes | IκBα |
T19355 | 9160-9164 | Protein | denotes | IKK2 |
T19354 | 9121-9125 | Protein | denotes | TAK1 |
T19353 | 9115-9119 | Protein | denotes | TAK1 |
T19352 | 9106-9110 | Protein | denotes | IKK2 |
T19351 | 9023-9027 | Protein | denotes | NEMO |
T19350 | 8999-9004 | Protein | denotes | IRAK1 |
T19349 | 8990-8994 | Protein | denotes | RIP1 |
T19348 | 8926-8931 | Protein | denotes | cIAP2 |
T19347 | 8919-8924 | Protein | denotes | cIAP1 |
T19346 | 8912-8917 | Protein | denotes | TRAF6 |
T19345 | 8905-8910 | Protein | denotes | TRAF2 |
T19344 | 8874-8879 | Protein | denotes | IRAK4 |
T19343 | 8867-8872 | Protein | denotes | IRAK1 |
T19342 | 8861-8865 | Protein | denotes | RIP1 |
T19341 | 8844-8848 | Protein | denotes | TRIF |
T19340 | 8799-8842 | Protein | denotes | TIR domain-containing adaptor-inducing IFNβ |
T19339 | 8794-8797 | Protein | denotes | MAL |
T19338 | 8787-8792 | Protein | denotes | MyD88 |
T19337 | 8779-8784 | Protein | denotes | TRADD |
T19336 | 8731-8777 | Protein | denotes | TNF receptor 1-associated death domain protein |
T19335 | 8672-8676 | Protein | denotes | TLR4 |
T19334 | 8662-8666 | Protein | denotes | RANK |
T19333 | 8656-8660 | Protein | denotes | CD40 |
T19332 | 8649-8654 | Protein | denotes | TNFR1 |
T17432 | 32702-32712 | Gene_expression | denotes | expression |
T17431 | 32659-32666 | Protein | denotes | miR-223 |
T17430 | 32646-32653 | Protein | denotes | miR-132 |
T17429 | 32638-32644 | Protein | denotes | miR-16 |
T17428 | 32575-32579 | Protein | denotes | IL-6 |
T17427 | 32544-32570 | Protein | denotes | matrix metalloproteinase-1 |
T17426 | 32531-32540 | Gene_expression | denotes | secretion |
T17425 | 32521-32530 | Positive_regulation | denotes | increased |
T17424 | 32500-32507 | Protein | denotes | miR-203 |
T17423 | 32481-32489 | Positive_regulation | denotes | elevated |
T17422 | 32368-32402 | Protein | denotes | monocyte chemoattractant protein 1 |
T17421 | 32341-32350 | Regulation | denotes | regulator |
T17420 | 32324-32332 | Protein | denotes | miR-124a |
T17419 | 32152-32159 | Protein | denotes | miR-155 |
T17418 | 31934-31944 | Gene_expression | denotes | expression |
T17417 | 31754-31761 | Protein | denotes | miR-155 |
T17416 | 31684-31694 | Gene_expression | denotes | production |
T17415 | 31680-31683 | Protein | denotes | TNF |
T17414 | 31672-31679 | Positive_regulation | denotes | promote |
T17413 | 31651-31658 | Protein | denotes | miR-155 |
T17412 | 31450-31457 | Protein | denotes | miR-155 |
T17411 | 31364-31372 | Protein | denotes | miR-146a |
T17410 | 31269-31278 | Gene_expression | denotes | producing |
T17409 | 31263-31268 | Protein | denotes | IL-17 |
T17408 | 31254-31257 | Protein | denotes | CD4 |
T17407 | 31220-31228 | Protein | denotes | miR-146a |
T17406 | 31055-31062 | Protein | denotes | miR-155 |
T17405 | 31015-31019 | Protein | denotes | RIP1 |
T17404 | 31006-31010 | Protein | denotes | IKKε |
T17403 | 30931-30938 | Protein | denotes | miR-155 |
T17402 | 30894-30902 | Protein | denotes | miR-146a |
T17401 | 30853-30858 | Protein | denotes | TRAF6 |
T17400 | 30843-30848 | Protein | denotes | IRAK1 |
T17399 | 30771-30779 | Protein | denotes | miR-146a |
T17398 | 30736-30739 | Protein | denotes | TNF |
T17397 | 30729-30734 | Protein | denotes | IL-1β |
T17396 | 30689-30696 | Positive_regulation | denotes | induced |
T17395 | 30590-30597 | Protein | denotes | miR-155 |
T17394 | 30584-30585 | Protein | denotes | b |
T17393 | 30575-30583 | Protein | denotes | miR-146a |
T17392 | 30444-30448 | Binding | denotes | bind |
T17391 | 32659-32666 | Protein | denotes | miR-223 |
T17390 | 32646-32653 | Protein | denotes | miR-132 |
T17389 | 32638-32644 | Protein | denotes | miR-16 |
T17388 | 32575-32579 | Protein | denotes | IL-6 |
T17387 | 32544-32570 | Protein | denotes | matrix metalloproteinase-1 |
T17386 | 32500-32507 | Protein | denotes | miR-203 |
T17385 | 32368-32402 | Protein | denotes | monocyte chemoattractant protein 1 |
T17384 | 32324-32332 | Protein | denotes | miR-124a |
T17383 | 32152-32159 | Protein | denotes | miR-155 |
T17382 | 31754-31761 | Protein | denotes | miR-155 |
T17381 | 31680-31683 | Protein | denotes | TNF |
T17380 | 31651-31658 | Protein | denotes | miR-155 |
T17379 | 31450-31457 | Protein | denotes | miR-155 |
T17378 | 31364-31372 | Protein | denotes | miR-146a |
T17377 | 31263-31268 | Protein | denotes | IL-17 |
T17376 | 31254-31257 | Protein | denotes | CD4 |
T17375 | 31220-31228 | Protein | denotes | miR-146a |
T17374 | 31055-31062 | Protein | denotes | miR-155 |
T17373 | 31015-31019 | Protein | denotes | RIP1 |
T17372 | 31006-31010 | Protein | denotes | IKKε |
T17371 | 30931-30938 | Protein | denotes | miR-155 |
T17370 | 30894-30902 | Protein | denotes | miR-146a |
T17369 | 30853-30858 | Protein | denotes | TRAF6 |
T17368 | 30843-30848 | Protein | denotes | IRAK1 |
T17367 | 30771-30779 | Protein | denotes | miR-146a |
T17366 | 30736-30739 | Protein | denotes | TNF |
T17365 | 30729-30734 | Protein | denotes | IL-1β |
T17364 | 30590-30597 | Protein | denotes | miR-155 |
T17363 | 30584-30585 | Protein | denotes | b |
T17362 | 30575-30583 | Protein | denotes | miR-146a |
T16340 | 29029-29034 | Protein | denotes | TRAF1 |
T16339 | 29015-29025 | Gene_expression | denotes | Expression |
T16338 | 28862-28867 | Protein | denotes | TRAF1 |
T16337 | 28798-28807 | Protein | denotes | ubiquitin |
T16336 | 28688-28693 | Protein | denotes | TRAF1 |
T16335 | 30190-30195 | Protein | denotes | TRAF1 |
T16334 | 30057-30062 | Protein | denotes | TRAF1 |
T16333 | 29955-29960 | Protein | denotes | TRAF1 |
T16332 | 29728-29731 | Protein | denotes | A20 |
T16331 | 29708-29713 | Protein | denotes | TRAF1 |
T16330 | 29595-29600 | Protein | denotes | TRAF1 |
T16329 | 29528-29533 | Protein | denotes | TRAF1 |
T16328 | 29426-29431 | Protein | denotes | TRAF2 |
T16327 | 29330-29335 | Protein | denotes | TRAF1 |
T16326 | 29299-29303 | Protein | denotes | CD40 |
T16325 | 29251-29256 | Protein | denotes | TRAF1 |
T16324 | 29170-29173 | Protein | denotes | TNF |
T16323 | 29122-29127 | Protein | denotes | TRAF1 |
T16322 | 29092-29095 | Protein | denotes | TNF |
T16321 | 29077-29082 | Protein | denotes | TRAF1 |
T16320 | 29051-29054 | Protein | denotes | TNF |
T16319 | 29029-29034 | Protein | denotes | TRAF1 |
T16318 | 28862-28867 | Protein | denotes | TRAF1 |
T16317 | 28798-28807 | Protein | denotes | ubiquitin |
T16316 | 28688-28693 | Protein | denotes | TRAF1 |
T16315 | 28655-28687 | Protein | denotes | TNF receptor-associated factor 1 |
T16362 | 30190-30195 | Protein | denotes | TRAF1 |
T16361 | 30171-30182 | Binding | denotes | association |
T16360 | 30057-30062 | Protein | denotes | TRAF1 |
T16359 | 29955-29960 | Protein | denotes | TRAF1 |
T16358 | 29728-29731 | Protein | denotes | A20 |
T16357 | 29708-29713 | Protein | denotes | TRAF1 |
T16356 | 29639-29646 | Binding | denotes | binding |
T16355 | 29595-29600 | Protein | denotes | TRAF1 |
T16354 | 29528-29533 | Protein | denotes | TRAF1 |
T16353 | 29426-29431 | Protein | denotes | TRAF2 |
T16352 | 29336-29345 | Negative_regulation | denotes | deficient |
T16351 | 29330-29335 | Protein | denotes | TRAF1 |
T16350 | 29299-29303 | Protein | denotes | CD40 |
T16349 | 29251-29256 | Protein | denotes | TRAF1 |
T16348 | 29170-29173 | Protein | denotes | TNF |
T16347 | 29128-29137 | Negative_regulation | denotes | deficient |
T16346 | 29122-29127 | Protein | denotes | TRAF1 |
T16345 | 29092-29095 | Protein | denotes | TNF |
T16344 | 29077-29082 | Protein | denotes | TRAF1 |
T16343 | 29059-29073 | Positive_regulation | denotes | overexpression |
T16342 | 29051-29054 | Protein | denotes | TNF |
T16341 | 29038-29047 | Positive_regulation | denotes | inducible |
T15482 | 28594-28600 | Protein | denotes | SIGIRR |
T15481 | 28510-28516 | Protein | denotes | SIGIRR |
T15480 | 28436-28446 | Gene_expression | denotes | expression |
T15479 | 28405-28411 | Protein | denotes | SIGIRR |
T15478 | 28391-28401 | Gene_expression | denotes | expression |
T15477 | 28219-28228 | Negative_regulation | denotes | deficient |
T15476 | 28212-28218 | Protein | denotes | SIGIRR |
T15475 | 28168-28174 | Protein | denotes | SIGIRR |
T15474 | 28019-28025 | Protein | denotes | SIGIRR |
T15473 | 27898-27907 | Gene_expression | denotes | expressed |
T15472 | 27843-27849 | Protein | denotes | SIGIRR |
T15471 | 27813-27819 | Protein | denotes | SIGIRR |
T15470 | 27717-27722 | Protein | denotes | IL-1R |
T15469 | 27666-27671 | Protein | denotes | TRAF6 |
T15468 | 27657-27662 | Protein | denotes | IRAK1 |
T15467 | 27650-27655 | Protein | denotes | MyD88 |
T15466 | 27616-27627 | Binding | denotes | interaction |
T15465 | 27566-27571 | Protein | denotes | IL-1R |
T15464 | 27553-27562 | Negative_regulation | denotes | inhibitor |
T15463 | 27464-27469 | Protein | denotes | TIR-8 |
T15462 | 27433-27439 | Protein | denotes | SIGIRR |
T15461 | 27388-27431 | Protein | denotes | Single-immunoglobulin IL-1 receptor-related |
T15460 | 27336-27379 | Protein | denotes | Single-immunoglobulin IL-1 receptor-related |
T15459 | 28594-28600 | Protein | denotes | SIGIRR |
T15458 | 28510-28516 | Protein | denotes | SIGIRR |
T15457 | 28405-28411 | Protein | denotes | SIGIRR |
T15456 | 28212-28218 | Protein | denotes | SIGIRR |
T15455 | 28168-28174 | Protein | denotes | SIGIRR |
T15454 | 28019-28025 | Protein | denotes | SIGIRR |
T15453 | 27843-27849 | Protein | denotes | SIGIRR |
T15452 | 27813-27819 | Protein | denotes | SIGIRR |
T15451 | 27717-27722 | Protein | denotes | IL-1R |
T15450 | 27666-27671 | Protein | denotes | TRAF6 |
T15449 | 27657-27662 | Protein | denotes | IRAK1 |
T15448 | 27650-27655 | Protein | denotes | MyD88 |
T15447 | 27566-27571 | Protein | denotes | IL-1R |
T15446 | 27464-27469 | Protein | denotes | TIR-8 |
T15445 | 27433-27439 | Protein | denotes | SIGIRR |
T15444 | 27388-27431 | Protein | denotes | Single-immunoglobulin IL-1 receptor-related |
T15443 | 27336-27379 | Protein | denotes | Single-immunoglobulin IL-1 receptor-related |
T14138 | 27244-27248 | Protein | denotes | CYLD |
T14137 | 27135-27139 | Protein | denotes | RANK |
T14136 | 27106-27110 | Protein | denotes | CYLD |
T14135 | 26993-26996 | Protein | denotes | p62 |
T14134 | 26896-26901 | Protein | denotes | TRAF6 |
T14133 | 26867-26875 | Positive_regulation | denotes | mediated |
T14132 | 26862-26866 | Protein | denotes | CYLD |
T14131 | 26824-26838 | Protein | denotes | sequestosome 1 |
T14130 | 26805-26808 | Protein | denotes | p62 |
T14129 | 26781-26788 | Binding | denotes | binding |
T14128 | 26771-26780 | Protein | denotes | ubiquitin |
T14127 | 26763-26766 | Positive_regulation | denotes | via |
T14126 | 26757-26762 | Protein | denotes | TRAF6 |
T14125 | 26730-26739 | Binding | denotes | recruited |
T14124 | 26696-26703 | Positive_regulation | denotes | induced |
T14123 | 26690-26695 | Protein | denotes | RANKL |
T14122 | 26630-26634 | Protein | denotes | CYLD |
T14121 | 26559-26564 | Protein | denotes | RANKL |
T14120 | 26420-26424 | Protein | denotes | CYLD |
T14119 | 26333-26337 | Protein | denotes | RANK |
T14118 | 26290-26294 | Protein | denotes | CYLD |
T14117 | 26143-26147 | Protein | denotes | CYLD |
T14116 | 25997-26006 | Gene_expression | denotes | expressed |
T14115 | 25985-25988 | Protein | denotes | A20 |
T14114 | 25948-25952 | Protein | denotes | CYLD |
T14113 | 25933-25936 | Protein | denotes | A20 |
T14112 | 25884-25887 | Protein | denotes | A20 |
T14111 | 25843-25847 | Protein | denotes | TAK1 |
T14110 | 25834-25838 | Protein | denotes | RIP1 |
T14109 | 25827-25832 | Protein | denotes | TRAF7 |
T14108 | 25820-25825 | Protein | denotes | TRAF6 |
T14107 | 25813-25818 | Protein | denotes | TRAF2 |
T14106 | 25807-25811 | Protein | denotes | NEMO |
T14105 | 25674-25678 | Protein | denotes | RANK |
T14104 | 25588-25611 | Protein | denotes | deubiquitinating enzyme |
T14103 | 25578-25582 | Protein | denotes | CYLD |
T14102 | 25385-25389 | Protein | denotes | CYLD |
T14101 | 25279-25283 | Protein | denotes | CYLD |
T14100 | 25262-25277 | Protein | denotes | Cylindromatosis |
T14099 | 25238-25253 | Protein | denotes | Cylindromatosis |
T14098 | 27244-27248 | Protein | denotes | CYLD |
T14097 | 27135-27139 | Protein | denotes | RANK |
T14096 | 27106-27110 | Protein | denotes | CYLD |
T14095 | 26993-26996 | Protein | denotes | p62 |
T14094 | 26896-26901 | Protein | denotes | TRAF6 |
T14093 | 26862-26866 | Protein | denotes | CYLD |
T14092 | 26824-26838 | Protein | denotes | sequestosome 1 |
T14091 | 26805-26808 | Protein | denotes | p62 |
T14090 | 26771-26780 | Protein | denotes | ubiquitin |
T14089 | 26757-26762 | Protein | denotes | TRAF6 |
T14088 | 26690-26695 | Protein | denotes | RANKL |
T14087 | 26630-26634 | Protein | denotes | CYLD |
T14086 | 26559-26564 | Protein | denotes | RANKL |
T14085 | 26420-26424 | Protein | denotes | CYLD |
T14084 | 26333-26337 | Protein | denotes | RANK |
T14083 | 26290-26294 | Protein | denotes | CYLD |
T14082 | 26143-26147 | Protein | denotes | CYLD |
T14081 | 25985-25988 | Protein | denotes | A20 |
T14080 | 25948-25952 | Protein | denotes | CYLD |
T14079 | 25933-25936 | Protein | denotes | A20 |
T14078 | 25884-25887 | Protein | denotes | A20 |
T14077 | 25843-25847 | Protein | denotes | TAK1 |
T14076 | 25834-25838 | Protein | denotes | RIP1 |
T14075 | 25827-25832 | Protein | denotes | TRAF7 |
T14074 | 25820-25825 | Protein | denotes | TRAF6 |
T14073 | 25813-25818 | Protein | denotes | TRAF2 |
T14072 | 25807-25811 | Protein | denotes | NEMO |
T14071 | 25674-25678 | Protein | denotes | RANK |
T14070 | 25588-25611 | Protein | denotes | deubiquitinating enzyme |
T14069 | 25578-25582 | Protein | denotes | CYLD |
T14068 | 25385-25389 | Protein | denotes | CYLD |
T14067 | 25279-25283 | Protein | denotes | CYLD |
T14066 | 25262-25277 | Protein | denotes | Cylindromatosis |
T14065 | 25238-25253 | Protein | denotes | Cylindromatosis |
T12639 | 24679-24685 | Protein | denotes | ABIN-1 |
T12638 | 24537-24540 | Protein | denotes | A20 |
T12637 | 24526-24532 | Protein | denotes | ABIN-3 |
T12636 | 24482-24492 | Gene_expression | denotes | expression |
T12635 | 24239-24242 | Protein | denotes | A20 |
T12634 | 24217-24223 | Protein | denotes | ABIN-1 |
T12633 | 24208-24212 | Regulation | denotes | role |
T12632 | 24136-24142 | Protein | denotes | ABIN-1 |
T12631 | 24121-24125 | Positive_regulation | denotes | high |
T12630 | 24080-24087 | Positive_regulation | denotes | induced |
T12629 | 24076-24079 | Protein | denotes | TNF |
T12628 | 24048-24054 | Protein | denotes | ABIN-1 |
T12627 | 23962-23965 | Protein | denotes | TNF |
T12626 | 23922-23931 | Negative_regulation | denotes | deficient |
T12625 | 23915-23921 | Protein | denotes | ABIN-1 |
T12624 | 23883-23886 | Protein | denotes | TNF |
T12623 | 23853-23859 | Protein | denotes | ABIN-1 |
T12622 | 23848-23851 | Protein | denotes | A20 |
T12621 | 23819-23834 | Entity | denotes | -binding domain |
T12620 | 23762-23789 | Protein | denotes | truncated and inactive form |
T12619 | 23717-23726 | Gene_expression | denotes | expressed |
T12618 | 23707-23713 | Protein | denotes | ABIN-3 |
T12617 | 23560-23569 | Positive_regulation | denotes | increased |
T12616 | 23523-23532 | Negative_regulation | denotes | deficient |
T12615 | 23516-23522 | Protein | denotes | ABIN-2 |
T12614 | 23502-23511 | Negative_regulation | denotes | deficient |
T12613 | 23495-23501 | Protein | denotes | ABIN-1 |
T12612 | 23383-23386 | Protein | denotes | A20 |
T12611 | 23315-23325 | Gene_expression | denotes | expression |
T12610 | 23308-23314 | Protein | denotes | ABIN-3 |
T12609 | 23297-23303 | Protein | denotes | ABIN-1 |
T12608 | 23292-23295 | Protein | denotes | A20 |
T12607 | 23236-23239 | Protein | denotes | A20 |
T12606 | 23229-23235 | Binding | denotes | target |
T12605 | 23080-23083 | Protein | denotes | TNF |
T12604 | 23066-23076 | Positive_regulation | denotes | activation |
T12603 | 23009-23012 | Protein | denotes | A20 |
T12602 | 22999-23008 | Gene_expression | denotes | expressed |
T12601 | 22959-22965 | Protein | denotes | TNIP-3 |
T12600 | 22947-22953 | Protein | denotes | TNIP-2 |
T12599 | 22939-22945 | Protein | denotes | TNIP-1 |
T12598 | 22917-22923 | Protein | denotes | ABIN-3 |
T12597 | 22906-22912 | Protein | denotes | ABIN-2 |
T12596 | 22898-22904 | Protein | denotes | ABIN-1 |
T12595 | 22866-22869 | Protein | denotes | A20 |
T12594 | 24679-24685 | Protein | denotes | ABIN-1 |
T12593 | 24537-24540 | Protein | denotes | A20 |
T12592 | 24526-24532 | Protein | denotes | ABIN-3 |
T12591 | 24239-24242 | Protein | denotes | A20 |
T12590 | 24217-24223 | Protein | denotes | ABIN-1 |
T12589 | 24136-24142 | Protein | denotes | ABIN-1 |
T12588 | 24076-24079 | Protein | denotes | TNF |
T12587 | 24048-24054 | Protein | denotes | ABIN-1 |
T12586 | 23962-23965 | Protein | denotes | TNF |
T12585 | 23915-23921 | Protein | denotes | ABIN-1 |
T12584 | 23883-23886 | Protein | denotes | TNF |
T12583 | 23853-23859 | Protein | denotes | ABIN-1 |
T12582 | 23848-23851 | Protein | denotes | A20 |
T12581 | 23762-23789 | Protein | denotes | truncated and inactive form |
T12580 | 23707-23713 | Protein | denotes | ABIN-3 |
T12579 | 23516-23522 | Protein | denotes | ABIN-2 |
T12578 | 23495-23501 | Protein | denotes | ABIN-1 |
T12577 | 23383-23386 | Protein | denotes | A20 |
T12576 | 23308-23314 | Protein | denotes | ABIN-3 |
T12575 | 23297-23303 | Protein | denotes | ABIN-1 |
T12574 | 23292-23295 | Protein | denotes | A20 |
T12573 | 23236-23239 | Protein | denotes | A20 |
T12572 | 23080-23083 | Protein | denotes | TNF |
T12571 | 23009-23012 | Protein | denotes | A20 |
T12570 | 22959-22965 | Protein | denotes | TNIP-3 |
T12569 | 22947-22953 | Protein | denotes | TNIP-2 |
T12568 | 22939-22945 | Protein | denotes | TNIP-1 |
T12567 | 22917-22923 | Protein | denotes | ABIN-3 |
T12566 | 22906-22912 | Protein | denotes | ABIN-2 |
T12565 | 22898-22904 | Protein | denotes | ABIN-1 |
T12564 | 22866-22869 | Protein | denotes | A20 |
T9631 | 22791-22794 | Protein | denotes | A20 |
T9630 | 22555-22558 | Protein | denotes | A20 |
T9629 | 22507-22510 | Protein | denotes | A20 |
T9628 | 22327-22330 | Protein | denotes | A20 |
T9627 | 22246-22249 | Protein | denotes | A20 |
T9626 | 22208-22216 | Protein | denotes | cytokine |
T9625 | 22176-22179 | Protein | denotes | TNF |
T9624 | 22151-22154 | Protein | denotes | TNF |
T9623 | 22116-22119 | Protein | denotes | A20 |
T9622 | 22029-22032 | Protein | denotes | A20 |
T9621 | 21982-21985 | Protein | denotes | A20 |
T9620 | 21828-21831 | Protein | denotes | A20 |
T9619 | 21607-21610 | Protein | denotes | A20 |
T9618 | 21461-21464 | Protein | denotes | A20 |
T9617 | 21257-21260 | Protein | denotes | A20 |
T9616 | 21162-21165 | Protein | denotes | A20 |
T9615 | 21013-21016 | Protein | denotes | A20 |
T9614 | 21004-21009 | Protein | denotes | IL-1β |
T9613 | 20996-20999 | Protein | denotes | TNF |
T9612 | 20970-20979 | Negative_regulation | denotes | decreased |
T9611 | 20869-20874 | Protein | denotes | IL-1β |
T9610 | 20861-20864 | Protein | denotes | TNF |
T9609 | 20703-20706 | Protein | denotes | A20 |
T9608 | 20639-20674 | Protein | denotes | monocyte chemo-attractant protein 1 |
T9607 | 20632-20637 | Protein | denotes | RANKL |
T9606 | 20618-20622 | Protein | denotes | IL-6 |
T9605 | 20611-20616 | Protein | denotes | IL-1β |
T9604 | 20606-20609 | Protein | denotes | TNF |
T9603 | 20586-20595 | Negative_regulation | denotes | decreased |
T9602 | 20499-20502 | Protein | denotes | A20 |
T9601 | 20271-20274 | Protein | denotes | A20 |
T9600 | 20168-20171 | Protein | denotes | A20 |
T9599 | 20131-20140 | Regulation | denotes | regulated |
T9598 | 20110-20120 | Gene_expression | denotes | expression |
T9597 | 20106-20109 | Protein | denotes | A20 |
T9596 | 19929-19932 | Protein | denotes | A20 |
T9595 | 19798-19801 | Protein | denotes | A20 |
T9594 | 19790-19797 | Negative_regulation | denotes | lacking |
T9593 | 19677-19680 | Protein | denotes | A20 |
T9592 | 19643-19646 | Protein | denotes | TNF |
T9591 | 19483-19486 | Protein | denotes | A20 |
T9590 | 19475-19482 | Negative_regulation | denotes | lacking |
T9589 | 19360-19363 | Protein | denotes | TNF |
T9588 | 19315-19324 | Negative_regulation | denotes | deficient |
T9587 | 19311-19314 | Protein | denotes | A20 |
T9586 | 19126-19129 | Protein | denotes | A20 |
T9585 | 19062-19065 | Protein | denotes | A20 |
T9584 | 18964-18967 | Protein | denotes | A20 |
T9583 | 18882-18904 | Protein | denotes | Tax1-binding protein 1 |
T9582 | 18838-18877 | Protein | denotes | A20-binding inhibitor of NF-κB (ABIN) 1 |
T9581 | 18802-18809 | Binding | denotes | binding |
T9580 | 18753-18756 | Protein | denotes | A20 |
T9579 | 18738-18749 | Binding | denotes | association |
T9578 | 18691-18694 | Protein | denotes | A20 |
T9577 | 18634-18635 | Protein | denotes | 2 |
T9576 | 18628-18633 | Protein | denotes | cIAP1 |
T9575 | 18618-18623 | Protein | denotes | TRAF2 |
T9574 | 18611-18616 | Protein | denotes | TRAF6 |
T9573 | 18577-18583 | Protein | denotes | Ubc5hc |
T9572 | 18567-18572 | Protein | denotes | Ubc13 |
T9571 | 18451-18463 | Binding | denotes | interactions |
T9557 | 22555-22558 | Protein | denotes | A20 |
T9556 | 22507-22510 | Protein | denotes | A20 |
T9555 | 22327-22330 | Protein | denotes | A20 |
T9554 | 22246-22249 | Protein | denotes | A20 |
T9553 | 22208-22216 | Protein | denotes | cytokine |
T9552 | 22176-22179 | Protein | denotes | TNF |
T9551 | 22151-22154 | Protein | denotes | TNF |
T9550 | 22116-22119 | Protein | denotes | A20 |
T9549 | 22029-22032 | Protein | denotes | A20 |
T9548 | 21982-21985 | Protein | denotes | A20 |
T9547 | 21828-21831 | Protein | denotes | A20 |
T9546 | 21607-21610 | Protein | denotes | A20 |
T9545 | 21461-21464 | Protein | denotes | A20 |
T9544 | 21257-21260 | Protein | denotes | A20 |
T9543 | 21162-21165 | Protein | denotes | A20 |
T9542 | 21013-21016 | Protein | denotes | A20 |
T9541 | 21004-21009 | Protein | denotes | IL-1β |
T9540 | 20996-20999 | Protein | denotes | TNF |
T9539 | 20869-20874 | Protein | denotes | IL-1β |
T9538 | 20861-20864 | Protein | denotes | TNF |
T9537 | 20703-20706 | Protein | denotes | A20 |
T9536 | 20639-20674 | Protein | denotes | monocyte chemo-attractant protein 1 |
T9535 | 20632-20637 | Protein | denotes | RANKL |
T9534 | 20618-20622 | Protein | denotes | IL-6 |
T9533 | 20611-20616 | Protein | denotes | IL-1β |
T9532 | 20606-20609 | Protein | denotes | TNF |
T9531 | 20499-20502 | Protein | denotes | A20 |
T9530 | 20271-20274 | Protein | denotes | A20 |
T9529 | 20168-20171 | Protein | denotes | A20 |
T9528 | 20106-20109 | Protein | denotes | A20 |
T9527 | 19929-19932 | Protein | denotes | A20 |
T9526 | 19798-19801 | Protein | denotes | A20 |
T9525 | 19677-19680 | Protein | denotes | A20 |
T9524 | 19643-19646 | Protein | denotes | TNF |
T9523 | 19483-19486 | Protein | denotes | A20 |
T9522 | 19360-19363 | Protein | denotes | TNF |
T9521 | 19311-19314 | Protein | denotes | A20 |
T9520 | 19126-19129 | Protein | denotes | A20 |
T9519 | 19062-19065 | Protein | denotes | A20 |
T9518 | 18964-18967 | Protein | denotes | A20 |
T9517 | 18882-18904 | Protein | denotes | Tax1-binding protein 1 |
T9516 | 18838-18877 | Protein | denotes | A20-binding inhibitor of NF-κB (ABIN) 1 |
T9515 | 18753-18756 | Protein | denotes | A20 |
T9514 | 18691-18694 | Protein | denotes | A20 |
T9513 | 18634-18635 | Protein | denotes | 2 |
T9512 | 18628-18633 | Protein | denotes | cIAP1 |
T9511 | 18618-18623 | Protein | denotes | TRAF2 |
T9510 | 18611-18616 | Protein | denotes | TRAF6 |
T9509 | 18577-18583 | Protein | denotes | Ubc5hc |
T9508 | 18567-18572 | Protein | denotes | Ubc13 |
T9507 | 18404-18409 | Protein | denotes | MALT1 |
T9506 | 18394-18399 | Protein | denotes | TRAF6 |
T9505 | 18388-18392 | Protein | denotes | RIP2 |
T9504 | 18382-18386 | Protein | denotes | RIP1 |
T9503 | 18275-18278 | Protein | denotes | A20 |
T9502 | 18132-18135 | Protein | denotes | TNF |
T9501 | 18038-18043 | Protein | denotes | NF-κB |
T9500 | 17986-18011 | Protein | denotes | ubiquitin-editing protein |
T9499 | 17972-17979 | Protein | denotes | TNFAIP3 |
T9498 | 17953-17956 | Protein | denotes | A20 |
T9497 | 17941-17944 | Protein | denotes | A20 |
T9570 | 18417-18425 | Negative_regulation | denotes | disrupts |
T9569 | 18404-18409 | Protein | denotes | MALT1 |
T9568 | 18394-18399 | Protein | denotes | TRAF6 |
T9567 | 18388-18392 | Protein | denotes | RIP2 |
T9566 | 18382-18386 | Protein | denotes | RIP1 |
T9565 | 18275-18278 | Protein | denotes | A20 |
T9564 | 18132-18135 | Protein | denotes | TNF |
T9563 | 18038-18043 | Protein | denotes | NF-κB |
T9562 | 17986-18011 | Protein | denotes | ubiquitin-editing protein |
T9561 | 17972-17979 | Protein | denotes | TNFAIP3 |
T9560 | 17953-17956 | Protein | denotes | A20 |
T9559 | 17941-17944 | Protein | denotes | A20 |
T9558 | 22791-22794 | Protein | denotes | A20 |
T8378 | 17781-17785 | Protein | denotes | IKK1 |
T8377 | 17680-17683 | Protein | denotes | NIK |
T8376 | 17660-17664 | Protein | denotes | IKK1 |
T8375 | 17596-17601 | Protein | denotes | STAT1 |
T8374 | 17480-17484 | Protein | denotes | IKK1 |
T8373 | 17462-17473 | Protein_catabolism | denotes | degradation |
T8372 | 17457-17461 | Protein | denotes | IκBα |
T8371 | 17442-17452 | Positive_regulation | denotes | activation |
T8370 | 17437-17441 | Protein | denotes | IKK2 |
T8369 | 17428-17436 | Positive_regulation | denotes | enhanced |
T8368 | 17353-17357 | Protein | denotes | IKK1 |
T8367 | 17333-17343 | Gene_expression | denotes | expressing |
T8366 | 17302-17311 | Negative_regulation | denotes | deficient |
T8365 | 17297-17301 | Protein | denotes | IKK1 |
T8364 | 17069-17073 | Protein | denotes | IKK1 |
T8363 | 16915-16921 | Protein | denotes | TOLLIP |
T8362 | 16903-16909 | Protein | denotes | IRAK-M |
T8361 | 16895-16901 | Protein | denotes | MyD88s |
T8360 | 17781-17785 | Protein | denotes | IKK1 |
T8359 | 17680-17683 | Protein | denotes | NIK |
T8358 | 17660-17664 | Protein | denotes | IKK1 |
T8357 | 17596-17601 | Protein | denotes | STAT1 |
T8356 | 17480-17484 | Protein | denotes | IKK1 |
T8355 | 17457-17461 | Protein | denotes | IκBα |
T8354 | 17437-17441 | Protein | denotes | IKK2 |
T8353 | 17353-17357 | Protein | denotes | IKK1 |
T8352 | 17297-17301 | Protein | denotes | IKK1 |
T8351 | 17069-17073 | Protein | denotes | IKK1 |
T8350 | 16915-16921 | Protein | denotes | TOLLIP |
T8349 | 16903-16909 | Protein | denotes | IRAK-M |
T8348 | 16895-16901 | Protein | denotes | MyD88s |
T4235 | 15890-15894 | Protein | denotes | CD40 |
T4234 | 15877-15886 | Negative_regulation | denotes | regulator |
T4233 | 15850-15855 | Protein | denotes | TRAF3 |
T4232 | 15812-15820 | Positive_regulation | denotes | required |
T4231 | 15803-15808 | Protein | denotes | TRAF2 |
T4230 | 15785-15795 | Gene_expression | denotes | production |
T4229 | 15780-15784 | Protein | denotes | IL-6 |
T4228 | 15747-15751 | Protein | denotes | CD40 |
T4227 | 15734-15742 | Positive_regulation | denotes | required |
T4226 | 15725-15730 | Protein | denotes | TRAF6 |
T4225 | 15676-15680 | Protein | denotes | CD40 |
T4224 | 15499-15504 | Protein | denotes | TRAF3 |
T4223 | 15489-15494 | Protein | denotes | TRAF2 |
T4222 | 15440-15445 | Protein | denotes | TRAF6 |
T4221 | 15429-15434 | Protein | denotes | TRAF5 |
T4220 | 15422-15427 | Protein | denotes | TRAF3 |
T4219 | 15415-15420 | Protein | denotes | TRAF2 |
T4218 | 15408-15413 | Protein | denotes | TRAF1 |
T4217 | 15362-15370 | Binding | denotes | interact |
T4216 | 15357-15361 | Protein | denotes | RANK |
T4215 | 15348-15352 | Protein | denotes | CD40 |
T4214 | 15323-15330 | Binding | denotes | binding |
T4213 | 15228-15232 | Protein | denotes | RANK |
T4212 | 15201-15223 | Protein | denotes | lymphotoxin β receptor |
T4211 | 15195-15199 | Protein | denotes | CD40 |
T4210 | 13803-13818 | Phosphorylation | denotes | phosphorylation |
T4209 | 13798-13802 | Protein | denotes | IKK1 |
T4208 | 13777-13780 | Protein | denotes | NIK |
T4207 | 13751-13762 | Protein_catabolism | denotes | degradation |
T4206 | 13725-13728 | Protein | denotes | NIK |
T4205 | 13678-13689 | Protein_catabolism | denotes | degradation |
T4204 | 13672-13677 | Protein | denotes | TRAF3 |
T4203 | 13647-13656 | Positive_regulation | denotes | essential |
T4202 | 13634-13635 | Protein | denotes | 2 |
T4201 | 13628-13633 | Protein | denotes | cIAP1 |
T4200 | 13618-13623 | Protein | denotes | TRAF2 |
T4199 | 13540-13545 | Protein | denotes | TRAF3 |
T4198 | 13457-13468 | Protein_catabolism | denotes | degradation |
T4197 | 13426-13429 | Protein | denotes | NIK |
T4196 | 13395-13396 | Protein | denotes | 2 |
T4195 | 13389-13394 | Protein | denotes | cIAP1 |
T4194 | 13378-13383 | Protein | denotes | TRAF3 |
T4193 | 13371-13376 | Protein | denotes | TRAF2 |
T4192 | 13330-13333 | Protein | denotes | NIK |
T4191 | 13185-13188 | Protein | denotes | NIK |
T4190 | 13179-13182 | Protein | denotes | NIK |
T4189 | 13156-13177 | Protein | denotes | NF-κB inducing kinase |
T4188 | 13137-13152 | Phosphorylation | denotes | phosphorylation |
T4187 | 13122-13131 | Positive_regulation | denotes | activated |
T4186 | 13107-13111 | Protein | denotes | IKK1 |
T4185 | 13094-13103 | Regulation | denotes | dependent |
T4184 | 12892-12896 | Protein | denotes | RelB |
T4183 | 12863-12866 | Protein | denotes | p52 |
T4182 | 12824-12828 | Protein | denotes | p100 |
T4181 | 12790-12794 | Protein | denotes | RANK |
T4180 | 12780-12784 | Protein | denotes | CD40 |
T4179 | 12765-12778 | Protein | denotes | BAFF receptor |
T4178 | 12741-12763 | Protein | denotes | lymphotoxin β receptor |
T4177 | 12724-12733 | Positive_regulation | denotes | activated |
T4176 | 12662-12665 | Protein | denotes | TNF |
T4175 | 12597-12601 | Protein | denotes | TAK1 |
T4133 | 11006-11045 | Protein | denotes | TNF receptor-associated factor (TRAF) 2 |
T4132 | 10935-10939 | Protein | denotes | RIP1 |
T4131 | 10903-10933 | Protein | denotes | receptor interacting protein 1 |
T4130 | 10881-10886 | Protein | denotes | TRADD |
T4129 | 10841-10879 | Protein | denotes | TNF receptor-1-associated death domain |
T4128 | 10826-10837 | Binding | denotes | recruitment |
T4127 | 10795-10798 | Protein | denotes | TNF |
T4126 | 10782-10785 | Protein | denotes | TNF |
T4125 | 8474-8478 | Protein | denotes | IKK1 |
T4124 | 8460-8464 | Protein | denotes | NEMO |
T4123 | 8451-8455 | Protein | denotes | IKK2 |
T4122 | 8394-8398 | Protein | denotes | IKKγ |
T4121 | 8373-8377 | Protein | denotes | NEMO |
T4120 | 8346-8371 | Protein | denotes | NF-κB essential modulator |
T4119 | 8313-8317 | Protein | denotes | IKKβ |
T4118 | 8304-8308 | Protein | denotes | IKKα |
T4117 | 8284-8288 | Protein | denotes | IKK2 |
T4116 | 8275-8279 | Protein | denotes | IKK1 |
T4115 | 8180-8191 | Protein_catabolism | denotes | degradation |
T4114 | 8092-8107 | Phosphorylation | denotes | phosphorylation |
T4113 | 8083-8091 | Positive_regulation | denotes | mediates |
T4112 | 7830-7835 | Protein | denotes | RANKL |
T4111 | 7808-7811 | Protein | denotes | TNF |
T4110 | 7481-7484 | Protein | denotes | p50 |
T4109 | 7473-7476 | Protein | denotes | p52 |
T4108 | 7446-7450 | Protein | denotes | p105 |
T4107 | 7437-7441 | Protein | denotes | p100 |
T4106 | 7374-7379 | Protein | denotes | Bcl-3 |
T4105 | 7365-7369 | Protein | denotes | IκBξ |
T4104 | 7344-7354 | Negative_regulation | denotes | inhibitors |
T4103 | 7326-7332 | Protein | denotes | NF-κB2 |
T4102 | 7306-7310 | Protein | denotes | p100 |
T4101 | 7297-7303 | Protein | denotes | NF-κB1 |
T4100 | 7277-7281 | Protein | denotes | p105 |
T4099 | 7271-7275 | Protein | denotes | IκBε |
T4098 | 7265-7269 | Protein | denotes | IκBβ |
T4097 | 7259-7263 | Protein | denotes | IκBα |
T4096 | 7193-7206 | Localization | denotes | translocation |
T4095 | 7171-7178 | Negative_regulation | denotes | prevent |
T4094 | 15890-15894 | Protein | denotes | CD40 |
T4093 | 15850-15855 | Protein | denotes | TRAF3 |
T4092 | 15803-15808 | Protein | denotes | TRAF2 |
T4091 | 15780-15784 | Protein | denotes | IL-6 |
T4090 | 15747-15751 | Protein | denotes | CD40 |
T4089 | 15725-15730 | Protein | denotes | TRAF6 |
T4088 | 15676-15680 | Protein | denotes | CD40 |
T4087 | 15499-15504 | Protein | denotes | TRAF3 |
T4086 | 15489-15494 | Protein | denotes | TRAF2 |
T4085 | 15440-15445 | Protein | denotes | TRAF6 |
T4084 | 15429-15434 | Protein | denotes | TRAF5 |
T4083 | 15422-15427 | Protein | denotes | TRAF3 |
T4082 | 15415-15420 | Protein | denotes | TRAF2 |
T4081 | 15408-15413 | Protein | denotes | TRAF1 |
T4080 | 15357-15361 | Protein | denotes | RANK |
T4079 | 15348-15352 | Protein | denotes | CD40 |
T4078 | 15228-15232 | Protein | denotes | RANK |
T4077 | 15201-15223 | Protein | denotes | lymphotoxin β receptor |
T4076 | 15195-15199 | Protein | denotes | CD40 |
T4075 | 13798-13802 | Protein | denotes | IKK1 |
T4074 | 13777-13780 | Protein | denotes | NIK |
T4073 | 13725-13728 | Protein | denotes | NIK |
T4072 | 13672-13677 | Protein | denotes | TRAF3 |
T4071 | 13634-13635 | Protein | denotes | 2 |
T4070 | 13628-13633 | Protein | denotes | cIAP1 |
T4069 | 13618-13623 | Protein | denotes | TRAF2 |
T4068 | 13540-13545 | Protein | denotes | TRAF3 |
T4067 | 13426-13429 | Protein | denotes | NIK |
T4066 | 13395-13396 | Protein | denotes | 2 |
T4065 | 13389-13394 | Protein | denotes | cIAP1 |
T4064 | 13378-13383 | Protein | denotes | TRAF3 |
T4063 | 13371-13376 | Protein | denotes | TRAF2 |
T4062 | 13330-13333 | Protein | denotes | NIK |
T4061 | 13185-13188 | Protein | denotes | NIK |
T4060 | 13179-13182 | Protein | denotes | NIK |
T4059 | 13156-13177 | Protein | denotes | NF-κB inducing kinase |
T4058 | 13107-13111 | Protein | denotes | IKK1 |
T4057 | 12892-12896 | Protein | denotes | RelB |
T4056 | 12863-12866 | Protein | denotes | p52 |
T4055 | 12824-12828 | Protein | denotes | p100 |
T4054 | 12790-12794 | Protein | denotes | RANK |
T4053 | 12780-12784 | Protein | denotes | CD40 |
T4052 | 12765-12778 | Protein | denotes | BAFF receptor |
T4051 | 12741-12763 | Protein | denotes | lymphotoxin β receptor |
T4050 | 12662-12665 | Protein | denotes | TNF |
T4049 | 12597-12601 | Protein | denotes | TAK1 |
T4048 | 12533-12537 | Protein | denotes | RIP1 |
T4047 | 12518-12523 | Protein | denotes | TRAF6 |
T4046 | 12499-12503 | Protein | denotes | TRIF |
T4045 | 12487-12492 | Protein | denotes | TRAF6 |
T4044 | 12427-12432 | Protein | denotes | TRAF6 |
T4043 | 12347-12352 | Protein | denotes | MyD88 |
T4042 | 12326-12330 | Protein | denotes | TRIF |
T4041 | 12281-12324 | Protein | denotes | TIR domain-containing adaptor-inducing IFNβ |
T4040 | 12270-12275 | Protein | denotes | MyD88 |
T4039 | 12220-12268 | Protein | denotes | myeloid differentiation primary response gene 88 |
T4038 | 12156-12160 | Protein | denotes | TRAM |
T4037 | 12125-12154 | Protein | denotes | TRIF-related adaptor molecule |
T4036 | 12116-12118 | Protein | denotes | Ma |
T4035 | 12060-12094 | Protein | denotes | Toll/IL-1 receptor adaptor protein |
T4034 | 11994-11998 | Protein | denotes | TLR4 |
T4033 | 11906-11910 | Protein | denotes | TAK1 |
T4032 | 11680-11683 | Protein | denotes | TNF |
T4031 | 11621-11625 | Protein | denotes | NEMO |
T4030 | 11529-11530 | Protein | denotes | 2 |
T4029 | 11524-11528 | Protein | denotes | TAB1 |
T4028 | 11515-11519 | Protein | denotes | NEMO |
T4027 | 11467-11471 | Protein | denotes | TAK1 |
T4026 | 11405-11409 | Protein | denotes | RIP1 |
T4025 | 11308-11312 | Protein | denotes | RIP1 |
T4024 | 11282-11283 | Protein | denotes | 2 |
T4023 | 11276-11281 | Protein | denotes | cIAP1 |
T4022 | 11270-11271 | Protein | denotes | 5 |
T4021 | 11264-11269 | Protein | denotes | TRAF2 |
T4020 | 11203-11207 | Protein | denotes | RIP1 |
T4019 | 11167-11170 | Protein | denotes | TNF |
T4018 | 11146-11151 | Protein | denotes | cIAP2 |
T4017 | 11101-11141 | Protein | denotes | cellular inhibitor of apoptosis (cIAP) 1 |
T4016 | 11050-11055 | Protein | denotes | TRAF5 |
T4015 | 11006-11045 | Protein | denotes | TNF receptor-associated factor (TRAF) 2 |
T4014 | 10935-10939 | Protein | denotes | RIP1 |
T4013 | 10903-10933 | Protein | denotes | receptor interacting protein 1 |
T4012 | 10881-10886 | Protein | denotes | TRADD |
T4011 | 10841-10879 | Protein | denotes | TNF receptor-1-associated death domain |
T4010 | 10795-10798 | Protein | denotes | TNF |
T4009 | 10782-10785 | Protein | denotes | TNF |
T4008 | 8474-8478 | Protein | denotes | IKK1 |
T4007 | 8460-8464 | Protein | denotes | NEMO |
T4006 | 8451-8455 | Protein | denotes | IKK2 |
T4005 | 8394-8398 | Protein | denotes | IKKγ |
T4004 | 8373-8377 | Protein | denotes | NEMO |
T4003 | 8346-8371 | Protein | denotes | NF-κB essential modulator |
T4002 | 8313-8317 | Protein | denotes | IKKβ |
T4001 | 8304-8308 | Protein | denotes | IKKα |
T4000 | 8284-8288 | Protein | denotes | IKK2 |
T3999 | 8275-8279 | Protein | denotes | IKK1 |
T3998 | 7830-7835 | Protein | denotes | RANKL |
T3997 | 7808-7811 | Protein | denotes | TNF |
T3996 | 7481-7484 | Protein | denotes | p50 |
T3995 | 7473-7476 | Protein | denotes | p52 |
T3994 | 7446-7450 | Protein | denotes | p105 |
T3993 | 7437-7441 | Protein | denotes | p100 |
T3992 | 7374-7379 | Protein | denotes | Bcl-3 |
T3991 | 7365-7369 | Protein | denotes | IκBξ |
T3990 | 7326-7332 | Protein | denotes | NF-κB2 |
T3989 | 7306-7310 | Protein | denotes | p100 |
T3988 | 7297-7303 | Protein | denotes | NF-κB1 |
T3987 | 7277-7281 | Protein | denotes | p105 |
T3986 | 7271-7275 | Protein | denotes | IκBε |
T3985 | 7265-7269 | Protein | denotes | IκBβ |
T3984 | 7259-7263 | Protein | denotes | IκBα |
T4174 | 12556-12567 | Binding | denotes | interaction |
T4173 | 12533-12537 | Protein | denotes | RIP1 |
T4172 | 12518-12523 | Protein | denotes | TRAF6 |
T4171 | 12509-12517 | Binding | denotes | recruits |
T4170 | 12499-12503 | Protein | denotes | TRIF |
T4169 | 12487-12492 | Protein | denotes | TRAF6 |
T4168 | 12427-12432 | Protein | denotes | TRAF6 |
T4167 | 12347-12352 | Protein | denotes | MyD88 |
T4166 | 12326-12330 | Protein | denotes | TRIF |
T4165 | 12281-12324 | Protein | denotes | TIR domain-containing adaptor-inducing IFNβ |
T4164 | 12270-12275 | Protein | denotes | MyD88 |
T4163 | 12220-12268 | Protein | denotes | myeloid differentiation primary response gene 88 |
T4162 | 12156-12160 | Protein | denotes | TRAM |
T4161 | 12125-12154 | Protein | denotes | TRIF-related adaptor molecule |
T4160 | 12116-12119 | Protein | denotes | Mal |
T4159 | 12060-12094 | Protein | denotes | Toll/IL-1 receptor adaptor protein |
T4158 | 12045-12056 | Binding | denotes | recruitment |
T4157 | 12033-12040 | Positive_regulation | denotes | induces |
T4156 | 11994-11998 | Protein | denotes | TLR4 |
T4155 | 11906-11910 | Protein | denotes | TAK1 |
T4154 | 11680-11683 | Protein | denotes | TNF |
T4153 | 11621-11625 | Protein | denotes | NEMO |
T4152 | 11529-11530 | Protein | denotes | 2 |
T4151 | 11524-11528 | Protein | denotes | TAB1 |
T4150 | 11515-11519 | Protein | denotes | NEMO |
T4149 | 11498-11505 | Binding | denotes | binding |
T4148 | 11467-11471 | Protein | denotes | TAK1 |
T4147 | 11447-11454 | Binding | denotes | recruit |
T4146 | 11405-11409 | Protein | denotes | RIP1 |
T4145 | 11308-11312 | Protein | denotes | RIP1 |
T4144 | 11282-11283 | Protein | denotes | 2 |
T4143 | 11276-11281 | Protein | denotes | cIAP1 |
T4142 | 11270-11271 | Protein | denotes | 5 |
T4141 | 11264-11269 | Protein | denotes | TRAF2 |
T4140 | 11203-11207 | Protein | denotes | RIP1 |
T4139 | 11197-11202 | Binding | denotes | bound |
T4138 | 11167-11170 | Protein | denotes | TNF |
T4137 | 11146-11151 | Protein | denotes | cIAP2 |
T4136 | 11101-11141 | Protein | denotes | cellular inhibitor of apoptosis (cIAP) 1 |
T4135 | 11071-11075 | Binding | denotes | bind |
T4134 | 11050-11055 | Protein | denotes | TRAF5 |
T1746 | 6759-6769 | Protein | denotes | tenascin C |
T1745 | 6749-6757 | Protein | denotes | biglycan |
T1744 | 6736-6747 | Protein | denotes | fibronectin |
T1743 | 6565-6569 | Protein | denotes | TLR4 |
T1742 | 6341-6367 | Protein | denotes | myeloid-related protein 14 |
T1741 | 6311-6336 | Protein | denotes | Myeloid-related protein 8 |
T1740 | 6248-6253 | Protein | denotes | HMGB1 |
T1739 | 6183-6188 | Protein | denotes | HMGB1 |
T1738 | 6138-6143 | Protein | denotes | HMGB1 |
T1737 | 6099-6111 | Protein | denotes | TLR4 ligands |
T1736 | 6032-6040 | Localization | denotes | released |
T1735 | 5954-5973 | Protein | denotes | chromatin component |
T1734 | 5927-5932 | Protein | denotes | HMGB1 |
T1733 | 5880-5925 | Protein | denotes | High mobility group box chromosomal protein 1 |
T1732 | 5011-5033 | Protein | denotes | lymphotoxin β receptor |
T1731 | 4957-4961 | Protein | denotes | BAFF |
T1730 | 4882-4891 | Gene_expression | denotes | producing |
T1729 | 4836-4840 | Protein | denotes | BAFF |
T1728 | 4810-4834 | Protein | denotes | B-cell activating factor |
T1727 | 4765-4775 | Gene_expression | denotes | expression |
T1726 | 4756-4764 | Positive_regulation | denotes | Enhanced |
T1725 | 4576-4580 | Protein | denotes | CD40 |
T1724 | 4302-4305 | Protein | denotes | CD4 |
T1723 | 4264-4273 | Gene_expression | denotes | expressed |
T1722 | 4235-4240 | Protein | denotes | CD154 |
T1721 | 4222-4233 | Protein | denotes | CD40 ligand |
T1720 | 4207-4214 | Binding | denotes | Binding |
T1719 | 4197-4200 | Protein | denotes | TNF |
T1718 | 3967-3976 | Gene_expression | denotes | expressed |
T1717 | 3919-3945 | Protein | denotes | TNF receptor family member |
T1716 | 3903-3907 | Protein | denotes | CD40 |
T1715 | 3789-3793 | Protein | denotes | RANK |
T1714 | 3693-3697 | Protein | denotes | RANK |
T1713 | 3664-3691 | Protein | denotes | receptor activator of NF-κB |
T1712 | 3450-3453 | Protein | denotes | TNF |
T1711 | 3375-3378 | Protein | denotes | TNF |
T1710 | 3316-3319 | Protein | denotes | TNF |
T1709 | 6759-6769 | Protein | denotes | tenascin C |
T1708 | 6749-6757 | Protein | denotes | biglycan |
T1707 | 6736-6747 | Protein | denotes | fibronectin |
T1706 | 6565-6569 | Protein | denotes | TLR4 |
T1705 | 6341-6367 | Protein | denotes | myeloid-related protein 14 |
T1704 | 6311-6336 | Protein | denotes | Myeloid-related protein 8 |
T1703 | 6248-6253 | Protein | denotes | HMGB1 |
T1702 | 6183-6188 | Protein | denotes | HMGB1 |
T1701 | 6138-6143 | Protein | denotes | HMGB1 |
T1700 | 6099-6111 | Protein | denotes | TLR4 ligands |
T1699 | 5954-5973 | Protein | denotes | chromatin component |
T1698 | 5927-5932 | Protein | denotes | HMGB1 |
T1697 | 5880-5925 | Protein | denotes | High mobility group box chromosomal protein 1 |
T1696 | 5011-5033 | Protein | denotes | lymphotoxin β receptor |
T1695 | 4957-4961 | Protein | denotes | BAFF |
T1694 | 4836-4840 | Protein | denotes | BAFF |
T1693 | 4810-4834 | Protein | denotes | B-cell activating factor |
T1692 | 4576-4580 | Protein | denotes | CD40 |
T1691 | 4302-4305 | Protein | denotes | CD4 |
T1690 | 4235-4240 | Protein | denotes | CD154 |
T1689 | 4222-4233 | Protein | denotes | CD40 ligand |
T1688 | 4197-4200 | Protein | denotes | TNF |
T1687 | 3919-3945 | Protein | denotes | TNF receptor family member |
T1686 | 3903-3907 | Protein | denotes | CD40 |
T1685 | 3789-3793 | Protein | denotes | RANK |
T1684 | 3693-3697 | Protein | denotes | RANK |
T1683 | 3664-3691 | Protein | denotes | receptor activator of NF-κB |
T1682 | 3450-3453 | Protein | denotes | TNF |
T1681 | 3375-3378 | Protein | denotes | TNF |
T1680 | 3316-3319 | Protein | denotes | TNF |
T320 | 2966-2971 | Protein | denotes | c-REL |
T319 | 2953-2960 | Protein | denotes | TNFAIP3 |
T318 | 2946-2951 | Protein | denotes | TRAF1 |
T317 | 2940-2944 | Protein | denotes | CD40 |
T316 | 2690-2695 | Protein | denotes | RANKL |
T315 | 2654-2688 | Protein | denotes | receptor activator of NF-κB ligand |
T314 | 2035-2038 | Protein | denotes | TNF |
T313 | 1932-1963 | Protein | denotes | inducible nitric oxide synthase |
T312 | 1901-1918 | Protein | denotes | cyclo-oxygenase-2 |
T311 | 1895-1899 | Protein | denotes | IL-6 |
T310 | 1884-1887 | Protein | denotes | TNF |
T309 | 1836-1846 | Gene_expression | denotes | expression |
T308 | 1823-1831 | Regulation | denotes | regulate |
T307 | 1758-1763 | Protein | denotes | c-Rel |
T306 | 1752-1756 | Protein | denotes | RelB |
T305 | 1746-1750 | Protein | denotes | RelA |
T304 | 1739-1742 | Protein | denotes | p65 |
T303 | 1731-1737 | Protein | denotes | NF-κB1 |
T302 | 1723-1727 | Protein | denotes | p105 |
T301 | 1715-1721 | Protein | denotes | NF-κB2 |
T300 | 1707-1711 | Protein | denotes | p100 |
T299 | 2966-2971 | Protein | denotes | c-REL |
T298 | 2953-2960 | Protein | denotes | TNFAIP3 |
T297 | 2946-2951 | Protein | denotes | TRAF1 |
T296 | 2940-2944 | Protein | denotes | CD40 |
T295 | 2690-2695 | Protein | denotes | RANKL |
T294 | 2654-2688 | Protein | denotes | receptor activator of NF-κB ligand |
T293 | 2035-2038 | Protein | denotes | TNF |
T292 | 1932-1963 | Protein | denotes | inducible nitric oxide synthase |
T291 | 1901-1918 | Protein | denotes | cyclo-oxygenase-2 |
T290 | 1895-1899 | Protein | denotes | IL-6 |
T289 | 1884-1887 | Protein | denotes | TNF |
T288 | 1758-1763 | Protein | denotes | c-Rel |
T287 | 1752-1756 | Protein | denotes | RelB |
T286 | 1746-1750 | Protein | denotes | RelA |
T285 | 1739-1742 | Protein | denotes | p65 |
T284 | 1731-1737 | Protein | denotes | NF-κB1 |
T283 | 1723-1727 | Protein | denotes | p105 |
T282 | 1715-1721 | Protein | denotes | NF-κB2 |
T281 | 1707-1711 | Protein | denotes | p100 |
R220 | T302 | T308 | causeOf | p105,regulate |
R221 | T304 | T308 | causeOf | p65,regulate |
R222 | T307 | T308 | causeOf | c-Rel,regulate |
R223 | T309 | T308 | themeOf | expression,regulate |
R224 | T310 | T309 | themeOf | TNF,expression |
R225 | T311 | T309 | themeOf | IL-6,expression |
R226 | T312 | T309 | themeOf | cyclo-oxygenase-2,expression |
R227 | T313 | T309 | themeOf | inducible nitric oxide synthase,expression |
R228 | T316 | T315 | equivalentTo | RANKL,receptor activator of NF-κB ligand |
R1282 | T1714 | T1713 | equivalentTo | RANK,receptor activator of NF-κB |
R1283 | T1715 | T1714 | themeOf | RANK,RANK |
R1284 | T1716 | T1718 | themeOf | CD40,expressed |
R1285 | T1717 | T1718 | themeOf | TNF receptor family member,expressed |
R1286 | T1721 | T1723 | themeOf | CD40 ligand,expressed |
R1287 | T1721 | T1720 | themeOf | CD40 ligand,Binding |
R1288 | T1722 | T1721 | equivalentTo | CD154,CD40 ligand |
R1289 | T1727 | T1726 | themeOf | expression,Enhanced |
R1290 | T1728 | T1727 | themeOf | B-cell activating factor,expression |
R1291 | T1729 | T1728 | equivalentTo | BAFF,B-cell activating factor |
R1292 | T1733 | T1736 | themeOf | High mobility group box chromosomal protein 1,released |
R1293 | T1733 | T1735 | themeOf | High mobility group box chromosomal protein 1,chromatin component |
R1294 | T1734 | T1735 | themeOf | HMGB1,chromatin component |
R1295 | T1734 | T1733 | equivalentTo | HMGB1,High mobility group box chromosomal protein 1 |
R1296 | T1735 | T1736 | themeOf | chromatin component,released |
R2841 | T4096 | T4095 | themeOf | translocation,prevent |
R2842 | T4105 | T4104 | themeOf | IκBξ,inhibitors |
R2843 | T4106 | T4104 | themeOf | Bcl-3,inhibitors |
R2844 | T4114 | T4113 | themeOf | phosphorylation,mediates |
R2845 | T4121 | T4120 | equivalentTo | NEMO,NF-κB essential modulator |
R2846 | T4129 | T4128 | themeOf | TNF receptor-1-associated death domain,recruitment |
R2847 | T4130 | T4129 | equivalentTo | TRADD,TNF receptor-1-associated death domain |
R2848 | T4131 | T4129 | equivalentTo | receptor interacting protein 1,TNF receptor-1-associated death domain |
R2849 | T4131 | T4135 | themeOf | receptor interacting protein 1,bind |
R2850 | T4131 | T4128 | themeOf | receptor interacting protein 1,recruitment |
R2851 | T4132 | T4129 | equivalentTo | RIP1,TNF receptor-1-associated death domain |
R2852 | T4132 | T4131 | equivalentTo | RIP1,receptor interacting protein 1 |
R2853 | T4133 | T4131 | equivalentTo | TNF receptor-associated factor (TRAF) 2,receptor interacting protein 1 |
R2854 | T4134 | T4135 | themeOf | TRAF5,bind |
R2855 | T4134 | T4128 | themeOf | TRAF5,recruitment |
R2856 | T4136 | T4135 | themeOf | cellular inhibitor of apoptosis (cIAP) 1,bind |
R2857 | T4137 | T4135 | themeOf | cIAP2,bind |
R2858 | T4140 | T4139 | themeOf | RIP1,bound |
R2859 | T4148 | T4147 | themeOf | TAK1,recruit |
R2860 | T4150 | T4149 | themeOf | NEMO,binding |
R2861 | T4151 | T4149 | themeOf | TAB1,binding |
R2862 | T4151 | T4147 | themeOf | TAB1,recruit |
R2863 | T4152 | T4149 | themeOf | 2,binding |
R2864 | T4156 | T4157 | causeOf | TLR4,induces |
R2865 | T4158 | T4157 | themeOf | recruitment,induces |
R2866 | T4159 | T4158 | themeOf | Toll/IL-1 receptor adaptor protein,recruitment |
R2867 | T4160 | T4158 | themeOf | Mal,recruitment |
R2868 | T4161 | T4158 | themeOf | TRIF-related adaptor molecule,recruitment |
R2869 | T4162 | T4159 | equivalentTo | TRAM,Toll/IL-1 receptor adaptor protein |
R2870 | T4162 | T4161 | equivalentTo | TRAM,TRIF-related adaptor molecule |
R2871 | T4164 | T4163 | equivalentTo | MyD88,myeloid differentiation primary response gene 88 |
R2872 | T4165 | T4158 | themeOf | TIR domain-containing adaptor-inducing IFNβ,recruitment |
R2873 | T4166 | T4165 | equivalentTo | TRIF,TIR domain-containing adaptor-inducing IFNβ |
R2874 | T4166 | T4163 | equivalentTo | TRIF,myeloid differentiation primary response gene 88 |
R2875 | T4170 | T4174 | themeOf | TRIF,interaction |
R2876 | T4170 | T4171 | themeOf | TRIF,recruits |
R2877 | T4172 | T4174 | themeOf | TRAF6,interaction |
R2878 | T4172 | T4171 | themeOf | TRAF6,recruits |
R2879 | T4173 | T4174 | themeOf | RIP1,interaction |
R2880 | T4173 | T4171 | themeOf | RIP1,recruits |
R2881 | T4178 | T4177 | causeOf | lymphotoxin β receptor,activated |
R2882 | T4186 | T4188 | themeOf | IKK1,phosphorylation |
R2883 | T4186 | T4185 | causeOf | IKK1,dependent |
R2884 | T4186 | T4187 | themeOf | IKK1,activated |
R2885 | T4189 | T4187 | causeOf | NF-κB inducing kinase,activated |
R2886 | T4189 | T4188 | causeOf | NF-κB inducing kinase,phosphorylation |
R2887 | T4190 | T4189 | equivalentTo | NIK,NF-κB inducing kinase |
R2888 | T4192 | T4198 | themeOf | NIK,degradation |
R2889 | T4193 | T4198 | themeOf | TRAF2,degradation |
R2890 | T4194 | T4198 | themeOf | TRAF3,degradation |
R2891 | T4195 | T4198 | themeOf | cIAP1,degradation |
R2892 | T4196 | T4198 | themeOf | 2,degradation |
R2893 | T4197 | T4198 | themeOf | NIK,degradation |
R2894 | T4204 | T4205 | themeOf | TRAF3,degradation |
R2895 | T4205 | T4203 | themeOf | degradation,essential |
R2896 | T4206 | T4207 | themeOf | NIK,degradation |
R2897 | T4208 | T4210 | themeOf | NIK,phosphorylation |
R2898 | T4209 | T4210 | themeOf | IKK1,phosphorylation |
R2899 | T4215 | T4214 | themeOf | CD40,binding |
R2900 | T4215 | T4217 | themeOf | CD40,interact |
R2901 | T4218 | T4214 | themeOf | TRAF1,binding |
R2902 | T4218 | T4217 | themeOf | TRAF1,interact |
R2903 | T4219 | T4217 | themeOf | TRAF2,interact |
R2904 | T4219 | T4214 | themeOf | TRAF2,binding |
R2905 | T4220 | T4217 | themeOf | TRAF3,interact |
R2906 | T4220 | T4214 | themeOf | TRAF3,binding |
R2907 | T4221 | T4214 | themeOf | TRAF5,binding |
R2908 | T4221 | T4217 | themeOf | TRAF5,interact |
R2909 | T4222 | T4214 | themeOf | TRAF6,binding |
R2910 | T4222 | T4217 | themeOf | TRAF6,interact |
R2911 | T4226 | T4227 | causeOf | TRAF6,required |
R2912 | T4229 | T4230 | themeOf | IL-6,production |
R2913 | T4231 | T4232 | causeOf | TRAF2,required |
R5571 | T8365 | T8366 | themeOf | IKK1,deficient |
R5572 | T8368 | T8367 | themeOf | IKK1,expressing |
R5573 | T8370 | T8373 | themeOf | IKK2,degradation |
R5574 | T8370 | T8371 | themeOf | IKK2,activation |
R5575 | T8371 | T8369 | themeOf | activation,enhanced |
R5576 | T8372 | T8373 | themeOf | IκBα,degradation |
R5577 | T8373 | T8369 | themeOf | degradation,enhanced |
R6359 | T9566 | T9571 | themeOf | RIP1,interactions |
R6360 | T9567 | T9571 | themeOf | RIP2,interactions |
R6361 | T9568 | T9571 | themeOf | TRAF6,interactions |
R6362 | T9569 | T9571 | themeOf | MALT1,interactions |
R6363 | T9571 | T9570 | themeOf | interactions,disrupts |
R6364 | T9580 | T9579 | themeOf | A20,association |
R6365 | T9587 | T9588 | themeOf | A20,deficient |
R6366 | T9591 | T9590 | themeOf | A20,lacking |
R6367 | T9595 | T9594 | themeOf | A20,lacking |
R6368 | T9597 | T9598 | themeOf | A20,expression |
R6369 | T9598 | T9599 | themeOf | expression,regulated |
R6370 | T9604 | T9603 | themeOf | TNF,decreased |
R6371 | T9605 | T9603 | themeOf | IL-1β,decreased |
R6372 | T9606 | T9603 | themeOf | IL-6,decreased |
R6373 | T9607 | T9603 | themeOf | RANKL,decreased |
R6374 | T9608 | T9603 | themeOf | monocyte chemo-attractant protein 1,decreased |
R6375 | T9613 | T9612 | themeOf | TNF,decreased |
R6376 | T9614 | T9612 | themeOf | IL-1β,decreased |
R8316 | T12596 | T12602 | themeOf | ABIN-1,expressed |
R8317 | T12597 | T12602 | themeOf | ABIN-2,expressed |
R8318 | T12598 | T12602 | themeOf | ABIN-3,expressed |
R8319 | T12599 | T12602 | themeOf | TNIP-1,expressed |
R8320 | T12600 | T12602 | themeOf | TNIP-2,expressed |
R8321 | T12601 | T12602 | themeOf | TNIP-3,expressed |
R8322 | T12603 | T12602 | themeOf | A20,expressed |
R8323 | T12607 | T12606 | themeOf | A20,target |
R8324 | T12608 | T12611 | themeOf | A20,expression |
R8325 | T12609 | T12611 | themeOf | ABIN-1,expression |
R8326 | T12610 | T12611 | themeOf | ABIN-3,expression |
R8327 | T12613 | T12614 | themeOf | ABIN-1,deficient |
R8328 | T12613 | T12616 | themeOf | ABIN-1,deficient |
R8329 | T12615 | T12616 | themeOf | ABIN-2,deficient |
R8330 | T12618 | T12620 | themeOf | ABIN-3,truncated and inactive form |
R8331 | T12618 | T12619 | themeOf | ABIN-3,expressed |
R8332 | T12619 | T12620 | themeOf | expressed,truncated and inactive form |
R8333 | T12625 | T12626 | themeOf | ABIN-1,deficient |
R8334 | T12630 | T12633 | themeOf | induced,role |
R8335 | T12634 | T12633 | causeOf | ABIN-1,role |
R8336 | T12637 | T12636 | themeOf | ABIN-3,expression |
R8337 | T12638 | T12636 | themeOf | A20,expression |
R9301 | T14101 | T14100 | equivalentTo | CYLD,Cylindromatosis |
R9302 | T14103 | T14105 | themeOf | CYLD,RANK |
R9303 | T14103 | T14104 | themeOf | CYLD,deubiquitinating enzyme |
R9304 | T14104 | T14105 | themeOf | deubiquitinating enzyme,RANK |
R9305 | T14115 | T14116 | themeOf | A20,expressed |
R9306 | T14118 | T14119 | themeOf | CYLD,RANK |
R9307 | T14123 | T14124 | causeOf | RANKL,induced |
R9308 | T14126 | T14125 | themeOf | TRAF6,recruited |
R9309 | T14130 | T14129 | themeOf | p62,binding |
R9310 | T14131 | T14127 | causeOf | sequestosome 1,via |
R9311 | T14132 | T14133 | causeOf | CYLD,mediated |
R10167 | T15461 | T15466 | themeOf | Single-immunoglobulin IL-1 receptor-related,interaction |
R10168 | T15462 | T15461 | equivalentTo | SIGIRR,Single-immunoglobulin IL-1 receptor-related |
R10169 | T15463 | T15466 | themeOf | TIR-8,interaction |
R10170 | T15463 | T15461 | equivalentTo | TIR-8,Single-immunoglobulin IL-1 receptor-related |
R10171 | T15465 | T15466 | themeOf | IL-1R,interaction |
R10172 | T15467 | T15466 | themeOf | MyD88,interaction |
R10173 | T15468 | T15466 | themeOf | IRAK1,interaction |
R10174 | T15469 | T15466 | themeOf | TRAF6,interaction |
R10175 | T15472 | T15473 | themeOf | SIGIRR,expressed |
R10176 | T15476 | T15477 | themeOf | SIGIRR,deficient |
R10177 | T15479 | T15478 | themeOf | SIGIRR,expression |
R10178 | T15479 | T15480 | themeOf | SIGIRR,expression |
R10759 | T16339 | T16341 | themeOf | Expression,inducible |
R10760 | T16340 | T16339 | themeOf | TRAF1,Expression |
R10761 | T16342 | T16341 | causeOf | TNF,inducible |
R10762 | T16343 | T16341 | causeOf | overexpression,inducible |
R10763 | T16344 | T16343 | themeOf | TRAF1,overexpression |
R10764 | T16346 | T16347 | themeOf | TRAF1,deficient |
R10765 | T16351 | T16352 | themeOf | TRAF1,deficient |
R10766 | T16355 | T16356 | themeOf | TRAF1,binding |
R10767 | T16362 | T16361 | themeOf | TRAF1,association |
R11392 | T17409 | T17410 | themeOf | IL-17,producing |
R11393 | T17413 | T17414 | causeOf | miR-155,promote |
R11394 | T17415 | T17416 | themeOf | TNF,production |
R11395 | T17416 | T17414 | themeOf | production,promote |
R11396 | T17426 | T17425 | themeOf | secretion,increased |
R11397 | T17427 | T17426 | themeOf | matrix metalloproteinase-1,secretion |
R11398 | T17428 | T17426 | themeOf | IL-6,secretion |
R11399 | T17429 | T17432 | themeOf | miR-16,expression |
R11400 | T17430 | T17432 | themeOf | miR-132,expression |
R11401 | T17431 | T17432 | themeOf | miR-223,expression |
R12799 | T19388 | T19393 | causeOf | engagement,trigger |
R12800 | T19389 | T19388 | themeOf | TNFR1,engagement |
R12801 | T19390 | T19388 | themeOf | CD40,engagement |
R12802 | T19391 | T19388 | themeOf | RANK,engagement |
R12803 | T19392 | T19393 | causeOf | TLR4,trigger |
R12804 | T19392 | T19388 | themeOf | TLR4,engagement |
R12805 | T19394 | T19393 | themeOf | recruitment,trigger |
R12806 | T19396 | T19395 | equivalentTo | TRADD,TNF receptor 1-associated death domain protein |
R12807 | T19398 | T19394 | themeOf | MAL,recruitment |
R12808 | T19399 | T19394 | themeOf | TIR domain-containing adaptor-inducing IFNβ,recruitment |
R12809 | T19400 | T19399 | equivalentTo | TRIF,TIR domain-containing adaptor-inducing IFNβ |
R12810 | T19401 | T19399 | equivalentTo | RIP1,TIR domain-containing adaptor-inducing IFNβ |
R12811 | T19404 | T19403 | equivalentTo | TRAF2,IRAK4 |
R12812 | T19404 | T19399 | equivalentTo | TRAF2,TIR domain-containing adaptor-inducing IFNβ |
R12813 | T19405 | T19394 | themeOf | TRAF6,recruitment |
R12814 | T19406 | T19394 | themeOf | cIAP1,recruitment |
R12815 | T19407 | T19394 | themeOf | cIAP2,recruitment |
R12816 | T19408 | T19412 | themeOf | RIP1,recruitment |
R12817 | T19409 | T19412 | themeOf | IRAK1,recruitment |
R12818 | T19410 | T19412 | themeOf | NEMO,recruitment |
R12819 | T19412 | T19411 | themeOf | recruitment,resulting |
R12820 | T19413 | T19412 | themeOf | IKK2,recruitment |
R12821 | T19414 | T19412 | themeOf | TAK1,recruitment |
R12822 | T19418 | T19417 | themeOf | IκBα,phosphorylates |
R12823 | T19420 | T19422 | themeOf | p65,translocate |
R12824 | T19421 | T19422 | themeOf | p50,translocate |
R12825 | T19423 | T19422 | locationOf | nucleus,translocate |
R12826 | T19425 | T19429 | themeOf | A20,recruited |
R12827 | T19426 | T19429 | themeOf | CYLD,recruited |
R12828 | T19427 | T19430 | themeOf | RIP1,binding |
R12829 | T19427 | T19429 | themeOf | RIP1,recruited |
R12830 | T19428 | T19429 | themeOf | TRAF6,recruited |
R12831 | T19428 | T19430 | themeOf | TRAF6,binding |
R12832 | T19431 | T19429 | themeOf | ABIN-1,recruited |
R12833 | T19432 | T19429 | themeOf | p62,recruited |
R12834 | T19432 | T19430 | themeOf | p62,binding |
R12835 | T19434 | T19433 | themeOf | expression,inhibiting |
R12836 | T19435 | T19434 | themeOf | IRAK1,expression |
R12837 | T19436 | T19434 | themeOf | TRAF6,expression |
R12838 | T19440 | T19441 | themeOf | TLR4,binding |
R12839 | T19441 | T19439 | themeOf | binding,compete |
R12840 | T19442 | T19441 | themeOf | IRAK1,binding |
R12841 | T19443 | T19441 | themeOf | TRAF6,binding |
R12842 | T19457 | T19452 | themeOf | single-immunoglobulinIL-1 receptor-related,RANK |
R13918 | T21362 | T21361 | equivalentTo | NIK,NF-κB inducing kinase |
R13919 | T21369 | T21368 | themeOf | NIK,degradation |
R13920 | T21372 | T21371 | themeOf | TRAF3,binding |
R13921 | T21372 | T21373 | themeOf | TRAF3,recruited |
R13922 | T21381 | T21382 | themeOf | TRAF3,degraded |
R13923 | T21385 | T21386 | causeOf | NIK,activates |
R13924 | T21385 | T21388 | causeOf | NIK,mediates |
R13925 | T21387 | T21386 | themeOf | IKK1,activates |
R13926 | T21387 | T21388 | causeOf | IKK1,mediates |
R13927 | T21389 | T21390 | themeOf | p100,phosphorylation |
R13928 | T21390 | T21388 | themeOf | phosphorylation,mediates |
R13929 | T21392 | T21391 | themeOf | p100,degradation |
R13930 | T21393 | T21391 | themeOf | p52,degradation |
R13931 | T21394 | T21391 | themeOf | RelB,degradation |