PMC:3216508 / 1882-2681 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3216508","sourcedb":"PMC","sourceid":"3216508","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3216508","text":"So far, a large number of polymorphisms in the human leucocyte antigens (HLA) have been discovered to be associated with TB susceptibility in a wide range of ethnic populations3. The variations in cytokines and their receptors have also been shown to influence susceptibility to TB. For example, A874T polymorphism in the first intron of interferon (IFN)-γ gene was reported to be associated with TB susceptibility in Sicilians4, South Africans5, and Chinese6. Other cytokines, such as IL-1, IL-2, IL-4, IL6, IL-10, IL-12, TNF-α, and TGF-β, have also been associated with TB3. A recent genome wide association study identified a single nucleotide polymorphism (SNP) in the gene desert region of 18q11.2 that was associated with tuberculosis with p-value of 6.8×10−9 in Ghana and Gambia populations7.","tracks":[]}