PMC:3216508 / 15741-16332 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3216508","sourcedb":"PMC","sourceid":"3216508","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3216508","text":"In summary, our study demonstrates an association between polymorphisms in the promoter of IL-22 gene and TB susceptibility. The rs2227473 polymorphism and associated SNPs in the promoter region of the IL-22 gene are associated with decreased susceptibility to pulmonary TB in Chinese. The ‘TGTAG' haplotype, which presents in 45.6% of the Chinese population, is associated with increased susceptibility to TB. The rs2227473 polymorphism affects IL-22's protein expression. Our SNP selection strategy focusing on regulatory SNPs is effective in identifying susceptive loci for the IL22 gene.","tracks":[]}