PMC:3216508 / 10748-11611 JSONTXT

{"project":"2_test","denotations":[{"id":"22355539-18264110-135382454","span":{"begin":82,"end":84},"obj":"18264110"},{"id":"22355539-15308104-135382455","span":{"begin":358,"end":360},"obj":"15308104"},{"id":"22355539-16619290-135382456","span":{"begin":452,"end":454},"obj":"16619290"},{"id":"22355539-19864591-135382457","span":{"begin":554,"end":556},"obj":"19864591"}],"text":"IL-22 has been reported to play a role in host defense against bacterial pathogens11. It is involved in host defense at environmental interfaces, such as mucosal surfaces of the airways and gastrointestinal tract. IL-22 can activate STAT3, which is a transcription activator that mediates the expression of a variety of genes in response to various cytokines14. It regulates genes that are involved in antimicrobial defense and cellular differentiation15. IL-22 can restrict the growth of M. tuberculosis in macrophages by enhancing phagolysosomal fusion10. However, the associations between genetic variations in the IL-22 gene and its promoter region and TB susceptibility have never been reported. In this study, we carried out this association study between the IL-22 gene, and found several SNPs in the IL-22 promoter region that influence TB susceptibility."}