PMC:3216504 / 8489-9143 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3216504","sourcedb":"PMC","sourceid":"3216504","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3216504","text":"We also observed abnormal behavioral traits in Zic2kd/+ mice in the Y-maze spontaneous alternation test. Zic2kd/+ mice showed a significantly lower alteration percentage (P = 0.046, U-test) and a significantly higher number of arm entries (P = 0.0040) than the wild-type mice (Figure 2C), suggesting that Zic2kd/+ mice have working memory impairment and a higher level of locomotor activity in a novel environment. Together with the absence of behavioral traits related to mood disturbances or anxiety-like behaviors, our results from the water maze, fear-conditioning and Y-maze tests are consistent with the impaired cognitive function in Zic2kd/+mice.","tracks":[]}