PMC:3216504 / 19900-20794 JSONTXT

{"project":"2_test","denotations":[{"id":"22355535-17015235-138031322","span":{"begin":805,"end":807},"obj":"17015235"},{"id":"22355535-12145742-138031323","span":{"begin":887,"end":889},"obj":"12145742"},{"id":"22355535-17512671-138031324","span":{"begin":887,"end":891},"obj":"17512671"},{"id":"22355535-17848917-138031325","span":{"begin":887,"end":893},"obj":"17848917"}],"text":"The locomotor activity differences between wild-type and Zic2kd/+ mice were context-dependent. In home cages, the mutant mice showed reduced locomotor activity in the early dark phase compared to wild-type mice, but in the open field test the mutant mice showed higher locomotor activity than wild-type mice. The tendency for Zic2kd/+ mice to display higher activity in a novel environment, compared to wild-type mice was also observed in the the Y-maze test and the light-dark box test (Figure S1C). Therefore, Zic2kd/+ mice appear to be generally hyperactive upon exposure to a novel environment. This hyperactivity is possibly consistent with symptoms of schizophrenia in humans; hyperactivity in response to a novel environment has been suggested as a useful animal correlate of schizophrenia symptoms34 and has been noted in some genetically engineered mouse models of schizophrenia353637."}