PMC:3148254 / 8815-12487
Annnotations
bionlp-st-ge-2016-reference
Id | Subject | Object | Predicate | Lexical cue | Speculation |
---|---|---|---|---|---|
T4174 | 0-4 | Protein | denotes | HOIP | |
T4175 | 8-16 | Positive_regulation | denotes | required | |
T4176 | 8-16 | Positive_regulation | denotes | required | |
T4177 | 21-25 | Protein | denotes | CD40 | |
T4178 | 26-34 | Positive_regulation | denotes | mediated | |
T4179 | 26-34 | Positive_regulation | denotes | mediated | |
T4180 | 35-39 | Protein | denotes | CD80 | |
T4181 | 40-52 | Positive_regulation | denotes | upregulation | |
T4182 | 57-67 | Positive_regulation | denotes | activation | |
T4183 | 71-87 | Protein | denotes | germline epsilon | |
T4184 | 88-101 | Transcription | denotes | transcription | |
T4185 | 102-112 | Binding | denotes | Engagement | |
T4186 | 116-120 | Protein | denotes | CD40 | |
T4187 | 132-143 | Positive_regulation | denotes | upregulates | |
T4188 | 144-154 | Gene_expression | denotes | expression | |
T4189 | 158-162 | Protein | denotes | CD80 | |
T4190 | 315-319 | Protein | denotes | HOIP | |
T4191 | 323-327 | Protein | denotes | CD40 | |
T4192 | 354-366 | Positive_regulation | denotes | upregulation | |
T4193 | 370-374 | Protein | denotes | CD80 | |
T4194 | 375-382 | Positive_regulation | denotes | induced | true |
T4195 | 386-396 | Binding | denotes | engagement | |
T4196 | 400-404 | Protein | denotes | CD40 | |
T4197 | 425-429 | Protein | denotes | HOIP | |
T4198 | 445-449 | Protein | denotes | HOIP | |
T4199 | 450-463 | Positive_regulation | denotes | reconstituted | |
T4200 | 520-524 | Protein | denotes | CD40 | |
T4201 | 525-535 | Positive_regulation | denotes | stimulated | |
T4202 | 536-548 | Positive_regulation | denotes | upregulation | |
T4203 | 552-556 | Protein | denotes | CD80 | |
T4204 | 574-581 | Negative_regulation | denotes | reduced | |
T4205 | 589-593 | Protein | denotes | HOIP | |
T4206 | 594-603 | Negative_regulation | denotes | deficient | |
T4207 | 631-643 | Positive_regulation | denotes | upregulation | |
T4208 | 647-651 | Protein | denotes | CD80 | |
T4209 | 668-672 | Protein | denotes | HOIP | |
T4210 | 673-686 | Positive_regulation | denotes | reconstituted | |
T4211 | 714-720 | Negative_regulation | denotes | defect | |
T4212 | 724-728 | Protein | denotes | CD80 | |
T4213 | 729-741 | Positive_regulation | denotes | upregulation | |
T4214 | 749-753 | Protein | denotes | HOIP | |
T4215 | 754-763 | Negative_regulation | denotes | deficient | |
T4216 | 774-777 | Positive_regulation | denotes | due | |
T4217 | 785-795 | Negative_regulation | denotes | disruption | |
T4218 | 799-804 | Protein | denotes | Rnf31 | |
T4219 | 1424-1428 | Protein | denotes | CD40 | |
T4220 | 1849-1853 | Protein | denotes | IL-4 | |
T4221 | 1858-1862 | Protein | denotes | CD40 | |
T4222 | 2064-2068 | Protein | denotes | HOIP | |
T4223 | 2181-2185 | Protein | denotes | CD40 | |
T4224 | 2205-2209 | Protein | denotes | IL-4 | |
T4225 | 2225-2235 | Transcription | denotes | production | true |
T4226 | 2239-2255 | Protein | denotes | germline epsilon | |
T4227 | 2257-2260 | Protein | denotes | GLε | |
T4228 | 2338-2342 | Protein | denotes | IL-4 | |
T4229 | 2343-2350 | Positive_regulation | denotes | induced | |
T4230 | 2351-2354 | Protein | denotes | GLε | |
T4231 | 2355-2368 | Transcription | denotes | transcription | |
T4232 | 2439-2442 | Protein | denotes | GLε | |
T4233 | 2443-2453 | Gene_expression | denotes | expression | |
T4234 | 2471-2475 | Protein | denotes | HOIP | |
T4235 | 2476-2485 | Negative_regulation | denotes | deficient | |
T4236 | 2557-2561 | Protein | denotes | IL-4 | |
T4237 | 2580-2583 | Protein | denotes | GLε | |
T4238 | 2584-2594 | Gene_expression | denotes | expression | |
T4239 | 2600-2607 | Positive_regulation | denotes | induced | |
T4240 | 2611-2615 | Protein | denotes | HOIP | |
T4241 | 2616-2629 | Positive_regulation | denotes | reconstituted | |
T4242 | 2694-2698 | Protein | denotes | IL-4 | |
T4243 | 2742-2746 | Protein | denotes | HOIP | |
T4244 | 2792-2796 | Protein | denotes | CD40 | |
T15371 | 850-854 | Protein | denotes | CD40 | |
T15372 | 855-863 | Positive_regulation | denotes | mediated | |
T15373 | 864-868 | Protein | denotes | CD80 | |
T15374 | 869-881 | Positive_regulation | denotes | upregulation | |
T15375 | 885-894 | Negative_regulation | denotes | defective | |
T15376 | 898-902 | Protein | denotes | HOIP | |
T15377 | 903-912 | Negative_regulation | denotes | deficient | |
T15378 | 1043-1053 | Gene_expression | denotes | expression | true |
T15379 | 1057-1061 | Protein | denotes | CD80 | |
T15380 | 1205-1209 | Protein | denotes | HOIP | |
T15381 | 1210-1219 | Negative_regulation | denotes | deficient | |
T15382 | 1221-1225 | Protein | denotes | HOIP | |
T15383 | 1269-1273 | Protein | denotes | HOIP | |
T15384 | 1274-1282 | Negative_regulation | denotes | reversed | |
T15385 | 1283-1292 | Negative_regulation | denotes | defective | |
T15386 | 1293-1297 | Protein | denotes | CD80 | |
T15387 | 1298-1310 | Positive_regulation | denotes | upregulation | |
T15715 | 2852-2855 | Protein | denotes | GLε | |
T15716 | 2856-2869 | Transcription | denotes | transcription | |
T15717 | 2873-2882 | Negative_regulation | denotes | defective | |
T15718 | 2886-2890 | Protein | denotes | CD40 | |
T15719 | 2902-2906 | Protein | denotes | HOIP | |
T15720 | 2907-2916 | Negative_regulation | denotes | deficient | |
T15721 | 2935-2939 | Protein | denotes | HOIP | |
T15722 | 2940-2949 | Negative_regulation | denotes | deficient | |
T15723 | 3018-3022 | Protein | denotes | HOIP | |
T15724 | 3052-3056 | Protein | denotes | HOIP | |
T15725 | 3057-3066 | Negative_regulation | denotes | deficient | |
T15726 | 3091-3095 | Protein | denotes | HOIP | |
T15727 | 3117-3121 | Protein | denotes | HOIP | |
T15728 | 3127-3131 | Protein | denotes | HOIP | |
T15729 | 3236-3240 | Protein | denotes | IL-4 | |
T15730 | 3358-3361 | Protein | denotes | GLε | |
T15731 | 3362-3373 | Transcription | denotes | transcripts | true |
T15732 | 3416-3421 | Protein | denotes | Hprt1 | |
T15733 | 3422-3433 | Transcription | denotes | transcripts | |
T15734 | 3648-3652 | Protein | denotes | HOIP | |
T15735 | 3653-3662 | Negative_regulation | denotes | deficient | |
R3207 | T4174 | T4176 | causeOf | HOIP,required | |
R3208 | T4174 | T4175 | causeOf | HOIP,required | |
R3209 | T4178 | T4175 | themeOf | mediated,required | |
R3210 | T4179 | T4176 | themeOf | mediated,required | |
R3211 | T4180 | T4181 | themeOf | CD80,upregulation | |
R3212 | T4181 | T4179 | themeOf | upregulation,mediated | |
R3213 | T4182 | T4178 | themeOf | activation,mediated | |
R3214 | T4183 | T4184 | themeOf | germline epsilon,transcription | |
R3215 | T4184 | T4182 | themeOf | transcription,activation | |
R3216 | T4185 | T4187 | causeOf | Engagement,upregulates | |
R3217 | T4186 | T4185 | themeOf | CD40,Engagement | |
R3218 | T4188 | T4187 | themeOf | expression,upregulates | |
R3219 | T4189 | T4188 | themeOf | CD80,expression | |
R3220 | T4192 | T4194 | themeOf | upregulation,induced | |
R3221 | T4193 | T4192 | themeOf | CD80,upregulation | |
R3222 | T4195 | T4194 | causeOf | engagement,induced | |
R3223 | T4196 | T4195 | themeOf | CD40,engagement | |
R3224 | T4198 | T4199 | themeOf | HOIP,reconstituted | |
R3225 | T4200 | T4201 | causeOf | CD40,stimulated | |
R3226 | T4202 | T4201 | themeOf | upregulation,stimulated | |
R3227 | T4202 | T4204 | themeOf | upregulation,reduced | |
R3228 | T4203 | T4202 | themeOf | CD80,upregulation | |
R3229 | T4205 | T4206 | themeOf | HOIP,deficient | |
R3230 | T4206 | T4204 | causeOf | deficient,reduced | |
R3231 | T4208 | T4207 | themeOf | CD80,upregulation | |
R3232 | T4209 | T4210 | themeOf | HOIP,reconstituted | |
R3233 | T4211 | T4216 | themeOf | defect,due | |
R3234 | T4212 | T4213 | themeOf | CD80,upregulation | |
R3235 | T4213 | T4211 | themeOf | upregulation,defect | |
R3236 | T4214 | T4215 | themeOf | HOIP,deficient | |
R3237 | T4215 | T4211 | causeOf | deficient,defect | |
R3238 | T4217 | T4216 | causeOf | disruption,due | |
R3239 | T4218 | T4217 | themeOf | Rnf31,disruption | |
R3240 | T4226 | T4225 | themeOf | germline epsilon,production | |
R3241 | T4227 | T4226 | equivalentTo | GLε,germline epsilon | |
R3242 | T4230 | T4231 | themeOf | GLε,transcription | |
R3243 | T4231 | T4229 | themeOf | transcription,induced | |
R3244 | T4232 | T4233 | themeOf | GLε,expression | |
R3245 | T4234 | T4235 | themeOf | HOIP,deficient | |
R3246 | T4237 | T4238 | themeOf | GLε,expression | |
R3247 | T4238 | T4239 | themeOf | expression,induced | |
R3248 | T4240 | T4241 | themeOf | HOIP,reconstituted | |
R12170 | T15371 | T15372 | causeOf | CD40,mediated | |
R12171 | T15372 | T15375 | themeOf | mediated,defective | |
R12172 | T15373 | T15374 | themeOf | CD80,upregulation | |
R12173 | T15374 | T15372 | themeOf | upregulation,mediated | |
R12174 | T15376 | T15377 | themeOf | HOIP,deficient | |
R12175 | T15379 | T15378 | themeOf | CD80,expression | |
R12176 | T15380 | T15381 | themeOf | HOIP,deficient | |
R12177 | T15385 | T15384 | themeOf | defective,reversed | |
R12178 | T15386 | T15387 | themeOf | CD80,upregulation | |
R12179 | T15387 | T15385 | themeOf | upregulation,defective | |
R12421 | T15715 | T15716 | themeOf | GLε,transcription | |
R12422 | T15716 | T15717 | themeOf | transcription,defective | |
R12423 | T15719 | T15720 | themeOf | HOIP,deficient | |
R12424 | T15721 | T15722 | themeOf | HOIP,deficient | |
R12425 | T15724 | T15725 | themeOf | HOIP,deficient | |
R12426 | T15730 | T15731 | themeOf | GLε,transcripts | |
R12427 | T15732 | T15733 | themeOf | Hprt1,transcripts | |
R12428 | T15734 | T15735 | themeOf | HOIP,deficient |
bionlp-st-ge-2016-reference-tees
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T5261 | 21-25 | Protein | denotes | CD40 |
T5262 | 35-39 | Protein | denotes | CD80 |
T5263 | 71-87 | Protein | denotes | germline epsilon |
T5264 | 40-52 | Positive_regulation | denotes | upregulation |
T5265 | 88-101 | Transcription | denotes | transcription |
T5266 | 57-67 | Positive_regulation | denotes | activation |
T5267 | 8-16 | Positive_regulation | denotes | required |
T5268 | 116-120 | Protein | denotes | CD40 |
T5269 | 158-162 | Protein | denotes | CD80 |
T5270 | 102-112 | Binding | denotes | Engagement |
T5271 | 144-154 | Gene_expression | denotes | expression |
T5272 | 132-143 | Positive_regulation | denotes | upregulates |
T5273 | 323-327 | Protein | denotes | CD40 |
T5274 | 370-374 | Protein | denotes | CD80 |
T5275 | 400-404 | Protein | denotes | CD40 |
T5276 | 354-366 | Positive_regulation | denotes | upregulation |
T5277 | 386-396 | Binding | denotes | engagement |
T5278 | 520-524 | Protein | denotes | CD40 |
T5279 | 552-556 | Protein | denotes | CD80 |
T5280 | 536-548 | Positive_regulation | denotes | upregulation |
T5281 | 574-581 | Negative_regulation | denotes | reduced |
T5282 | 647-651 | Protein | denotes | CD80 |
T5283 | 724-728 | Protein | denotes | CD80 |
T5284 | 799-804 | Protein | denotes | Rnf31 |
T5285 | 631-643 | Positive_regulation | denotes | upregulation |
T5286 | 729-741 | Positive_regulation | denotes | upregulation |
T5287 | 785-795 | Negative_regulation | denotes | disruption |
T5288 | 714-720 | Negative_regulation | denotes | defect |
T5289 | 1424-1428 | Protein | denotes | CD40 |
T5290 | 1514-1528 | Protein | denotes | immunoglobulin |
T5291 | 1582-1596 | Protein | denotes | immunoglobulin |
T5292 | 1674-1677 | Protein | denotes | IgM |
T5293 | 1692-1695 | Protein | denotes | IgA |
T5294 | 1697-1700 | Protein | denotes | IgG |
T5295 | 1705-1708 | Protein | denotes | IgE |
T5296 | 1663-1673 | Gene_expression | denotes | expressing |
T5297 | 1682-1688 | Binding | denotes | switch |
T5298 | 1808-1811 | Protein | denotes | IgE |
T5299 | 1849-1853 | Protein | denotes | IL-4 |
T5300 | 1858-1870 | Protein | denotes | CD40 signals |
T5301 | 1834-1845 | Binding | denotes | combination |
T5302 | 1819-1826 | Positive_regulation | denotes | induced |
T5303 | 1909-1912 | Protein | denotes | IgE |
T5304 | 2015-2018 | Protein | denotes | IgE |
T5305 | 1913-1923 | Gene_expression | denotes | production |
T5306 | 1895-1904 | Positive_regulation | denotes | necessary |
T5307 | 2181-2185 | Protein | denotes | CD40 |
T5308 | 2205-2209 | Protein | denotes | IL-4 |
T5309 | 2284-2302 | Protein | denotes | Anti-CD40 antibody |
T5310 | 2338-2342 | Protein | denotes | IL-4 |
T5311 | 2303-2314 | Positive_regulation | denotes | stimulation |
T5312 | 2520-2524 | Protein | denotes | CD40 |
T5313 | 2548-2552 | Protein | denotes | CD40 |
T5314 | 2557-2561 | Protein | denotes | IL-4 |
T5315 | 2652-2670 | Protein | denotes | anti-CD40 antibody |
T5316 | 2792-2796 | Protein | denotes | CD40 |
T15644 | 850-854 | Protein | denotes | CD40 |
T15645 | 864-868 | Protein | denotes | CD80 |
T15646 | 869-881 | Positive_regulation | denotes | upregulation |
T15647 | 885-894 | Negative_regulation | denotes | defective |
T15648 | 855-863 | Positive_regulation | denotes | mediated |
T15649 | 960-984 | Protein | denotes | isotype control antibody |
T15650 | 1000-1004 | Protein | denotes | CD40 |
T15651 | 1057-1061 | Protein | denotes | CD80 |
T15652 | 1107-1111 | Protein | denotes | CD80 |
T15653 | 1157-1181 | Protein | denotes | isotype control antibody |
T15654 | 1043-1053 | Gene_expression | denotes | expression |
T15655 | 1293-1297 | Protein | denotes | CD80 |
T15656 | 1298-1310 | Positive_regulation | denotes | upregulation |
T15657 | 1274-1282 | Negative_regulation | denotes | reversed |
T16092 | 2886-2890 | Protein | denotes | CD40 |
T16093 | 3177-3181 | Protein | denotes | CD40 |
T16094 | 3188-3212 | Protein | denotes | isotype control antibody |
T16095 | 3214-3217 | Protein | denotes | iso |
T16096 | 3236-3240 | Protein | denotes | IL-4 |
T16097 | 3358-3373 | Protein | denotes | GLε transcripts |
T16098 | 3416-3433 | Protein | denotes | Hprt1 transcripts |
R4084 | T5262 | T5264 | themeOf | CD80,upregulation |
R4085 | T5263 | T5265 | themeOf | germline epsilon,transcription |
R4086 | T5265 | T5266 | themeOf | transcription,activation |
R4087 | T5266 | T5267 | themeOf | activation,required |
R4088 | T5268 | T5270 | themeOf | CD40,Engagement |
R4089 | T5269 | T5271 | themeOf | CD80,expression |
R4090 | T5270 | T5272 | causeOf | Engagement,upregulates |
R4091 | T5271 | T5272 | themeOf | expression,upregulates |
R4092 | T5274 | T5276 | themeOf | CD80,upregulation |
R4093 | T5275 | T5277 | themeOf | CD40,engagement |
R4094 | T5278 | T5280 | causeOf | CD40,upregulation |
R4095 | T5279 | T5280 | themeOf | CD80,upregulation |
R4096 | T5280 | T5281 | themeOf | upregulation,reduced |
R4097 | T5282 | T5285 | themeOf | CD80,upregulation |
R4098 | T5283 | T5286 | themeOf | CD80,upregulation |
R4099 | T5284 | T5287 | themeOf | Rnf31,disruption |
R4100 | T5286 | T5288 | themeOf | upregulation,defect |
R4101 | T5292 | T5296 | themeOf | IgM,expressing |
R4102 | T5295 | T5297 | themeOf | IgE,switch |
R4103 | T5298 | T5302 | themeOf | IgE,induced |
R4104 | T5300 | T5301 | themeOf | CD40 signals,combination |
R4105 | T5301 | T5302 | causeOf | combination,induced |
R4106 | T5303 | T5305 | themeOf | IgE,production |
R4107 | T5305 | T5306 | themeOf | production,necessary |
R4108 | T5309 | T5311 | themeOf | Anti-CD40 antibody,stimulation |
R12390 | T15644 | T15648 | causeOf | CD40,mediated |
R12391 | T15645 | T15646 | themeOf | CD80,upregulation |
R12392 | T15646 | T15647 | themeOf | upregulation,defective |
R12393 | T15646 | T15648 | themeOf | upregulation,mediated |
R12394 | T15651 | T15654 | themeOf | CD80,expression |
R12395 | T15655 | T15656 | themeOf | CD80,upregulation |
R12396 | T15656 | T15657 | themeOf | upregulation,reversed |
events-check-again
Id | Subject | Object | Predicate | Lexical cue | Speculation |
---|---|---|---|---|---|
T5317 | 0-4 | Protein | denotes | HOIP | |
T5318 | 8-16 | Positive_regulation | denotes | required | |
T5319 | 8-16 | Positive_regulation | denotes | required | |
T5320 | 21-25 | Protein | denotes | CD40 | |
T5321 | 26-34 | Positive_regulation | denotes | mediated | |
T5322 | 26-34 | Positive_regulation | denotes | mediated | |
T5323 | 35-39 | Protein | denotes | CD80 | |
T5324 | 40-52 | Positive_regulation | denotes | upregulation | |
T5325 | 57-67 | Positive_regulation | denotes | activation | |
T5326 | 71-87 | Protein | denotes | germline epsilon | |
T5327 | 88-101 | Transcription | denotes | transcription | |
T5328 | 102-112 | Binding | denotes | Engagement | |
T5329 | 116-120 | Protein | denotes | CD40 | |
T5330 | 132-143 | Positive_regulation | denotes | upregulates | |
T5331 | 144-154 | Gene_expression | denotes | expression | |
T5332 | 158-162 | Protein | denotes | CD80 | |
T5333 | 315-319 | Protein | denotes | HOIP | |
T5334 | 323-327 | Protein | denotes | CD40 | |
T5335 | 354-366 | Positive_regulation | denotes | upregulation | |
T5336 | 370-374 | Protein | denotes | CD80 | |
T5337 | 375-382 | Positive_regulation | denotes | induced | true |
T5338 | 386-396 | Binding | denotes | engagement | |
T5339 | 400-404 | Protein | denotes | CD40 | |
T5340 | 425-429 | Protein | denotes | HOIP | |
T5341 | 445-449 | Protein | denotes | HOIP | |
T5342 | 450-463 | Positive_regulation | denotes | reconstituted | |
T5343 | 520-524 | Protein | denotes | CD40 | |
T5344 | 525-535 | Positive_regulation | denotes | stimulated | |
T5345 | 536-548 | Positive_regulation | denotes | upregulation | |
T5346 | 552-556 | Protein | denotes | CD80 | |
T5347 | 574-581 | Negative_regulation | denotes | reduced | |
T5348 | 589-593 | Protein | denotes | HOIP | |
T5349 | 594-603 | Negative_regulation | denotes | deficient | |
T5350 | 631-643 | Positive_regulation | denotes | upregulation | |
T5351 | 647-651 | Protein | denotes | CD80 | |
T5352 | 668-672 | Protein | denotes | HOIP | |
T5353 | 673-686 | Positive_regulation | denotes | reconstituted | |
T5354 | 714-720 | Negative_regulation | denotes | defect | |
T5355 | 724-728 | Protein | denotes | CD80 | |
T5356 | 729-741 | Positive_regulation | denotes | upregulation | |
T5357 | 749-753 | Protein | denotes | HOIP | |
T5358 | 754-763 | Negative_regulation | denotes | deficient | |
T5359 | 774-777 | Positive_regulation | denotes | due | |
T5360 | 785-795 | Negative_regulation | denotes | disruption | |
T5361 | 799-804 | Protein | denotes | Rnf31 | |
T5362 | 1424-1428 | Protein | denotes | CD40 | |
T5363 | 1849-1853 | Protein | denotes | IL-4 | |
T5364 | 1858-1862 | Protein | denotes | CD40 | |
T5365 | 2064-2068 | Protein | denotes | HOIP | |
T5366 | 2181-2185 | Protein | denotes | CD40 | |
T5367 | 2205-2209 | Protein | denotes | IL-4 | |
T5368 | 2225-2235 | Transcription | denotes | production | true |
T5369 | 2239-2255 | Protein | denotes | germline epsilon | |
T5370 | 2257-2260 | Protein | denotes | GLε | |
T5371 | 2338-2342 | Protein | denotes | IL-4 | |
T5372 | 2343-2350 | Positive_regulation | denotes | induced | |
T5373 | 2351-2354 | Protein | denotes | GLε | |
T5374 | 2355-2368 | Transcription | denotes | transcription | |
T5375 | 2439-2442 | Protein | denotes | GLε | |
T5376 | 2443-2453 | Gene_expression | denotes | expression | |
T5377 | 2471-2475 | Protein | denotes | HOIP | |
T5378 | 2476-2485 | Negative_regulation | denotes | deficient | |
T5379 | 2557-2561 | Protein | denotes | IL-4 | |
T5380 | 2580-2583 | Protein | denotes | GLε | |
T5381 | 2584-2594 | Gene_expression | denotes | expression | |
T5382 | 2600-2607 | Positive_regulation | denotes | induced | |
T5383 | 2611-2615 | Protein | denotes | HOIP | |
T5384 | 2616-2629 | Positive_regulation | denotes | reconstituted | |
T5385 | 2694-2698 | Protein | denotes | IL-4 | |
T5386 | 2742-2746 | Protein | denotes | HOIP | |
T5387 | 2792-2796 | Protein | denotes | CD40 | |
T15658 | 850-854 | Protein | denotes | CD40 | |
T15659 | 855-863 | Positive_regulation | denotes | mediated | |
T15660 | 864-868 | Protein | denotes | CD80 | |
T15661 | 869-881 | Positive_regulation | denotes | upregulation | |
T15662 | 885-894 | Negative_regulation | denotes | defective | |
T15663 | 898-902 | Protein | denotes | HOIP | |
T15664 | 903-912 | Negative_regulation | denotes | deficient | |
T15665 | 1043-1053 | Gene_expression | denotes | expression | true |
T15666 | 1057-1061 | Protein | denotes | CD80 | |
T15667 | 1205-1209 | Protein | denotes | HOIP | |
T15668 | 1210-1219 | Negative_regulation | denotes | deficient | |
T15669 | 1221-1225 | Protein | denotes | HOIP | |
T15670 | 1269-1273 | Protein | denotes | HOIP | |
T15671 | 1274-1282 | Negative_regulation | denotes | reversed | |
T15672 | 1283-1292 | Negative_regulation | denotes | defective | |
T15673 | 1293-1297 | Protein | denotes | CD80 | |
T15674 | 1298-1310 | Positive_regulation | denotes | upregulation | |
T16099 | 2852-2855 | Protein | denotes | GLε | |
T16100 | 2856-2869 | Transcription | denotes | transcription | |
T16101 | 2873-2882 | Negative_regulation | denotes | defective | |
T16102 | 2886-2890 | Protein | denotes | CD40 | |
T16103 | 2902-2906 | Protein | denotes | HOIP | |
T16104 | 2907-2916 | Negative_regulation | denotes | deficient | |
T16105 | 2935-2939 | Protein | denotes | HOIP | |
T16106 | 2940-2949 | Negative_regulation | denotes | deficient | |
T16107 | 3018-3022 | Protein | denotes | HOIP | |
T16108 | 3052-3056 | Protein | denotes | HOIP | |
T16109 | 3057-3066 | Negative_regulation | denotes | deficient | |
T16110 | 3091-3095 | Protein | denotes | HOIP | |
T16111 | 3117-3121 | Protein | denotes | HOIP | |
T16112 | 3127-3131 | Protein | denotes | HOIP | |
T16113 | 3236-3240 | Protein | denotes | IL-4 | |
T16114 | 3358-3361 | Protein | denotes | GLε | |
T16115 | 3362-3373 | Transcription | denotes | transcripts | true |
T16116 | 3416-3421 | Protein | denotes | Hprt1 | |
T16117 | 3422-3433 | Transcription | denotes | transcripts | |
T16118 | 3648-3652 | Protein | denotes | HOIP | |
T16119 | 3653-3662 | Negative_regulation | denotes | deficient | |
R4109 | T5317 | T5319 | causeOf | HOIP,required | |
R4110 | T5317 | T5318 | causeOf | HOIP,required | |
R4111 | T5321 | T5318 | themeOf | mediated,required | |
R4112 | T5322 | T5319 | themeOf | mediated,required | |
R4113 | T5323 | T5324 | themeOf | CD80,upregulation | |
R4114 | T5324 | T5322 | themeOf | upregulation,mediated | |
R4115 | T5325 | T5321 | themeOf | activation,mediated | |
R4116 | T5326 | T5327 | themeOf | germline epsilon,transcription | |
R4117 | T5327 | T5325 | themeOf | transcription,activation | |
R4118 | T5328 | T5330 | causeOf | Engagement,upregulates | |
R4119 | T5329 | T5328 | themeOf | CD40,Engagement | |
R4120 | T5331 | T5330 | themeOf | expression,upregulates | |
R4121 | T5332 | T5331 | themeOf | CD80,expression | |
R4122 | T5335 | T5337 | themeOf | upregulation,induced | |
R4123 | T5336 | T5335 | themeOf | CD80,upregulation | |
R4124 | T5338 | T5337 | causeOf | engagement,induced | |
R4125 | T5339 | T5338 | themeOf | CD40,engagement | |
R4126 | T5341 | T5342 | themeOf | HOIP,reconstituted | |
R4127 | T5343 | T5344 | causeOf | CD40,stimulated | |
R4128 | T5345 | T5344 | themeOf | upregulation,stimulated | |
R4129 | T5345 | T5347 | themeOf | upregulation,reduced | |
R4130 | T5346 | T5345 | themeOf | CD80,upregulation | |
R4131 | T5348 | T5349 | themeOf | HOIP,deficient | |
R4132 | T5349 | T5347 | causeOf | deficient,reduced | |
R4133 | T5351 | T5350 | themeOf | CD80,upregulation | |
R4134 | T5352 | T5353 | themeOf | HOIP,reconstituted | |
R4135 | T5354 | T5359 | themeOf | defect,due | |
R4136 | T5355 | T5356 | themeOf | CD80,upregulation | |
R4137 | T5356 | T5354 | themeOf | upregulation,defect | |
R4138 | T5357 | T5358 | themeOf | HOIP,deficient | |
R4139 | T5358 | T5354 | causeOf | deficient,defect | |
R4140 | T5360 | T5359 | causeOf | disruption,due | |
R4141 | T5361 | T5360 | themeOf | Rnf31,disruption | |
R4142 | T5369 | T5368 | themeOf | germline epsilon,production | |
R4143 | T5370 | T5369 | equivalentTo | GLε,germline epsilon | |
R4144 | T5373 | T5374 | themeOf | GLε,transcription | |
R4145 | T5374 | T5372 | themeOf | transcription,induced | |
R4146 | T5375 | T5376 | themeOf | GLε,expression | |
R4147 | T5377 | T5378 | themeOf | HOIP,deficient | |
R4148 | T5380 | T5381 | themeOf | GLε,expression | |
R4149 | T5381 | T5382 | themeOf | expression,induced | |
R4150 | T5383 | T5384 | themeOf | HOIP,reconstituted | |
R12397 | T15658 | T15659 | causeOf | CD40,mediated | |
R12398 | T15659 | T15662 | themeOf | mediated,defective | |
R12399 | T15660 | T15661 | themeOf | CD80,upregulation | |
R12400 | T15661 | T15659 | themeOf | upregulation,mediated | |
R12401 | T15663 | T15664 | themeOf | HOIP,deficient | |
R12402 | T15666 | T15665 | themeOf | CD80,expression | |
R12403 | T15667 | T15668 | themeOf | HOIP,deficient | |
R12404 | T15672 | T15671 | themeOf | defective,reversed | |
R12405 | T15673 | T15674 | themeOf | CD80,upregulation | |
R12406 | T15674 | T15672 | themeOf | upregulation,defective | |
R12727 | T16099 | T16100 | themeOf | GLε,transcription | |
R12728 | T16100 | T16101 | themeOf | transcription,defective | |
R12729 | T16103 | T16104 | themeOf | HOIP,deficient | |
R12730 | T16105 | T16106 | themeOf | HOIP,deficient | |
R12731 | T16108 | T16109 | themeOf | HOIP,deficient | |
R12732 | T16114 | T16115 | themeOf | GLε,transcripts | |
R12733 | T16116 | T16117 | themeOf | Hprt1,transcripts | |
R12734 | T16118 | T16119 | themeOf | HOIP,deficient |
pmc-enju-pas
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T4639 | 0-4 | NN | denotes | HOIP |
T4640 | 5-7 | VB | denotes | is |
T4641 | 8-16 | VB | denotes | required |
T4642 | 17-20 | IN | denotes | for |
T4643 | 21-34 | JJ | denotes | CD40-mediated |
T4644 | 35-39 | NN | denotes | CD80 |
T4645 | 40-52 | NN | denotes | upregulation |
T4646 | 53-56 | CC | denotes | and |
T4647 | 57-67 | NN | denotes | activation |
T4648 | 68-70 | IN | denotes | of |
T4649 | 71-79 | NN | denotes | germline |
T4650 | 80-87 | NN | denotes | epsilon |
T4651 | 88-101 | NN | denotes | transcription |
T4652 | 102-112 | NN | denotes | Engagement |
T4653 | 113-115 | IN | denotes | of |
T4654 | 116-120 | NN | denotes | CD40 |
T4655 | 121-123 | IN | denotes | on |
T4656 | 124-125 | NN | denotes | B |
T4657 | 126-131 | NN | denotes | cells |
T4658 | 132-143 | VB | denotes | upregulates |
T4659 | 144-154 | NN | denotes | expression |
T4660 | 155-157 | IN | denotes | of |
T4661 | 158-162 | NN | denotes | CD80 |
T4662 | 163-164 | -LRB- | denotes | [ |
T4663 | 164-166 | CD | denotes | 10 |
T4664 | 166-167 | -RRB- | denotes | ] |
T4665 | 167-168 | -COMMA- | denotes | , |
T4666 | 169-170 | DT | denotes | a |
T4667 | 171-175 | NN | denotes | cell |
T4668 | 176-183 | NN | denotes | surface |
T4669 | 184-191 | NN | denotes | protein |
T4670 | 192-196 | WDT | denotes | that |
T4671 | 197-205 | VB | denotes | promotes |
T4672 | 206-216 | NN | denotes | activation |
T4673 | 217-219 | IN | denotes | of |
T4674 | 220-221 | NN | denotes | T |
T4675 | 222-227 | NN | denotes | cells |
T4676 | 228-239 | VB | denotes | interacting |
T4677 | 240-244 | IN | denotes | with |
T4678 | 245-246 | NN | denotes | B |
T4679 | 247-252 | NN | denotes | cells |
T4680 | 253-256 | CC | denotes | and |
T4681 | 257-262 | JJ | denotes | other |
T4682 | 263-266 | NN | denotes | APC |
T4683 | 268-270 | TO | denotes | To |
T4684 | 271-276 | VB | denotes | begin |
T4685 | 277-287 | VB | denotes | evaluating |
T4686 | 288-297 | JJ | denotes | potential |
T4687 | 298-311 | NN | denotes | contributions |
T4688 | 312-314 | IN | denotes | of |
T4689 | 315-319 | NN | denotes | HOIP |
T4690 | 320-322 | TO | denotes | to |
T4691 | 323-327 | NN | denotes | CD40 |
T4692 | 328-337 | NN | denotes | signaling |
T4693 | 337-338 | -COMMA- | denotes | , |
T4694 | 339-341 | PRP | denotes | we |
T4695 | 342-349 | VB | denotes | assayed |
T4696 | 350-353 | DT | denotes | the |
T4697 | 354-366 | NN | denotes | upregulation |
T4698 | 367-369 | IN | denotes | of |
T4699 | 370-374 | NN | denotes | CD80 |
T4700 | 375-382 | VB | denotes | induced |
T4701 | 383-385 | IN | denotes | by |
T4702 | 386-396 | NN | denotes | engagement |
T4703 | 397-399 | IN | denotes | of |
T4704 | 400-404 | NN | denotes | CD40 |
T4705 | 405-407 | IN | denotes | on |
T4706 | 408-416 | JJ | denotes | parental |
T4707 | 417-423 | NN | denotes | A20.2J |
T4708 | 423-424 | -COMMA- | denotes | , |
T4709 | 425-439 | JJ | denotes | HOIP-deficient |
T4710 | 439-440 | -COMMA- | denotes | , |
T4711 | 441-444 | CC | denotes | and |
T4712 | 445-463 | JJ | denotes | HOIP-reconstituted |
T4713 | 464-469 | NN | denotes | cells |
T4714 | 470-471 | -LRB- | denotes | ( |
T4715 | 471-475 | NN | denotes | Fig. |
T4716 | 476-477 | CD | denotes | 2 |
T4717 | 477-478 | -RRB- | denotes | ) |
T4718 | 480-488 | VB | denotes | Compared |
T4719 | 489-491 | TO | denotes | to |
T4720 | 492-495 | DT | denotes | the |
T4721 | 496-504 | JJ | denotes | parental |
T4722 | 505-509 | NN | denotes | cell |
T4723 | 510-514 | NN | denotes | line |
T4724 | 514-515 | -COMMA- | denotes | , |
T4725 | 516-519 | DT | denotes | the |
T4726 | 520-535 | JJ | denotes | CD40-stimulated |
T4727 | 536-548 | NN | denotes | upregulation |
T4728 | 549-551 | IN | denotes | of |
T4729 | 552-556 | NN | denotes | CD80 |
T4730 | 557-560 | VB | denotes | was |
T4731 | 561-573 | RB | denotes | dramatically |
T4732 | 574-581 | VB | denotes | reduced |
T4733 | 582-584 | IN | denotes | in |
T4734 | 585-588 | DT | denotes | all |
T4735 | 589-603 | JJ | denotes | HOIP-deficient |
T4736 | 604-609 | NN | denotes | cells |
T4737 | 610-616 | VB | denotes | tested |
T4738 | 618-620 | IN | denotes | In |
T4739 | 621-629 | NN | denotes | contrast |
T4740 | 629-630 | -COMMA- | denotes | , |
T4741 | 631-643 | NN | denotes | upregulation |
T4742 | 644-646 | IN | denotes | of |
T4743 | 647-651 | NN | denotes | CD80 |
T4744 | 652-655 | VB | denotes | was |
T4745 | 656-664 | VB | denotes | restored |
T4746 | 665-667 | IN | denotes | in |
T4747 | 668-686 | JJ | denotes | HOIP-reconstituted |
T4748 | 687-692 | NN | denotes | cells |
T4749 | 692-693 | -COMMA- | denotes | , |
T4750 | 694-704 | VB | denotes | confirming |
T4751 | 705-709 | IN | denotes | that |
T4752 | 710-713 | DT | denotes | the |
T4753 | 714-720 | NN | denotes | defect |
T4754 | 721-723 | IN | denotes | in |
T4755 | 724-728 | NN | denotes | CD80 |
T4756 | 729-741 | NN | denotes | upregulation |
T4757 | 742-744 | IN | denotes | in |
T4758 | 745-748 | DT | denotes | the |
T4759 | 749-763 | JJ | denotes | HOIP-deficient |
T4760 | 764-769 | NN | denotes | cells |
T4761 | 770-773 | VB | denotes | was |
T4762 | 774-777 | JJ | denotes | due |
T4763 | 778-780 | TO | denotes | to |
T4764 | 781-784 | DT | denotes | the |
T4765 | 785-795 | NN | denotes | disruption |
T4766 | 796-798 | IN | denotes | of |
T4767 | 799-804 | NN | denotes | Rnf31 |
T4768 | 1424-1428 | NN | denotes | CD40 |
T4769 | 1429-1436 | NN | denotes | signals |
T4770 | 1437-1439 | IN | denotes | in |
T4771 | 1440-1441 | NN | denotes | B |
T4772 | 1442-1447 | NN | denotes | cells |
T4773 | 1448-1451 | MD | denotes | can |
T4774 | 1452-1456 | RB | denotes | also |
T4775 | 1457-1467 | VB | denotes | contribute |
T4776 | 1468-1470 | TO | denotes | to |
T4777 | 1471-1474 | DT | denotes | the |
T4778 | 1475-1485 | NN | denotes | activation |
T4779 | 1486-1488 | IN | denotes | of |
T4780 | 1489-1492 | NN | denotes | DNA |
T4781 | 1493-1506 | NN | denotes | recombination |
T4782 | 1507-1509 | IN | denotes | in |
T4783 | 1510-1513 | DT | denotes | the |
T4784 | 1514-1528 | NN | denotes | immunoglobulin |
T4785 | 1529-1534 | JJ | denotes | heavy |
T4786 | 1535-1540 | NN | denotes | chain |
T4787 | 1541-1546 | NN | denotes | locus |
T4788 | 1547-1548 | -LRB- | denotes | [ |
T4789 | 1548-1550 | CD | denotes | 11 |
T4790 | 1550-1551 | -RRB- | denotes | ] |
T4791 | 1551-1552 | -COMMA- | denotes | , |
T4792 | 1553-1554 | -LRB- | denotes | [ |
T4793 | 1554-1556 | CD | denotes | 12 |
T4794 | 1556-1557 | -RRB- | denotes | ] |
T4795 | 1559-1563 | DT | denotes | This |
T4796 | 1564-1571 | NN | denotes | process |
T4797 | 1571-1572 | -COMMA- | denotes | , |
T4798 | 1573-1578 | VB | denotes | known |
T4799 | 1579-1581 | IN | denotes | as |
T4800 | 1582-1596 | NN | denotes | immunoglobulin |
T4801 | 1597-1602 | NN | denotes | class |
T4802 | 1603-1612 | NN | denotes | switching |
T4803 | 1613-1614 | -LRB- | denotes | ( |
T4804 | 1614-1616 | CC | denotes | or |
T4805 | 1617-1624 | NN | denotes | isotype |
T4806 | 1625-1634 | NN | denotes | switching |
T4807 | 1634-1635 | -RRB- | denotes | ) |
T4808 | 1635-1636 | -COMMA- | denotes | , |
T4809 | 1637-1643 | VB | denotes | allows |
T4810 | 1644-1645 | NN | denotes | B |
T4811 | 1646-1651 | NN | denotes | cells |
T4812 | 1651-1652 | -COMMA- | denotes | , |
T4813 | 1653-1662 | RB | denotes | initially |
T4814 | 1663-1673 | VB | denotes | expressing |
T4815 | 1674-1677 | NN | denotes | IgM |
T4816 | 1677-1678 | -COMMA- | denotes | , |
T4817 | 1679-1681 | TO | denotes | to |
T4818 | 1682-1688 | VB | denotes | switch |
T4819 | 1689-1691 | TO | denotes | to |
T4820 | 1692-1695 | NN | denotes | IgA |
T4821 | 1695-1696 | -COMMA- | denotes | , |
T4822 | 1697-1700 | NN | denotes | IgG |
T4823 | 1700-1701 | -COMMA- | denotes | , |
T4824 | 1702-1704 | CC | denotes | or |
T4825 | 1705-1708 | NN | denotes | IgE |
T4826 | 1709-1718 | VB | denotes | depending |
T4827 | 1719-1721 | IN | denotes | on |
T4828 | 1722-1725 | DT | denotes | the |
T4829 | 1726-1731 | NN | denotes | class |
T4830 | 1732-1734 | IN | denotes | of |
T4831 | 1735-1743 | NN | denotes | antibody |
T4832 | 1744-1748 | RB | denotes | most |
T4833 | 1749-1760 | JJ | denotes | appropriate |
T4834 | 1761-1764 | IN | denotes | for |
T4835 | 1765-1766 | DT | denotes | a |
T4836 | 1767-1777 | JJ | denotes | particular |
T4837 | 1778-1784 | JJ | denotes | immune |
T4838 | 1785-1793 | NN | denotes | response |
T4839 | 1795-1804 | VB | denotes | Switching |
T4840 | 1805-1807 | TO | denotes | to |
T4841 | 1808-1811 | NN | denotes | IgE |
T4842 | 1812-1815 | MD | denotes | can |
T4843 | 1816-1818 | VB | denotes | be |
T4844 | 1819-1826 | VB | denotes | induced |
T4845 | 1827-1829 | IN | denotes | by |
T4846 | 1830-1833 | DT | denotes | the |
T4847 | 1834-1845 | NN | denotes | combination |
T4848 | 1846-1848 | IN | denotes | of |
T4849 | 1849-1853 | NN | denotes | IL-4 |
T4850 | 1854-1857 | CC | denotes | and |
T4851 | 1858-1862 | NN | denotes | CD40 |
T4852 | 1863-1870 | NN | denotes | signals |
T4853 | 1872-1875 | DT | denotes | The |
T4854 | 1876-1880 | NN | denotes | gene |
T4855 | 1881-1894 | NN | denotes | rearrangement |
T4856 | 1895-1904 | JJ | denotes | necessary |
T4857 | 1905-1908 | IN | denotes | for |
T4858 | 1909-1912 | NN | denotes | IgE |
T4859 | 1913-1923 | NN | denotes | production |
T4860 | 1924-1926 | VB | denotes | is |
T4861 | 1927-1935 | VB | denotes | preceded |
T4862 | 1936-1938 | IN | denotes | by |
T4863 | 1939-1942 | DT | denotes | the |
T4864 | 1943-1953 | NN | denotes | production |
T4865 | 1954-1956 | IN | denotes | of |
T4866 | 1957-1967 | JJ | denotes | non-coding |
T4867 | 1968-1971 | NN | denotes | RNA |
T4868 | 1972-1983 | NN | denotes | transcripts |
T4869 | 1984-1988 | IN | denotes | from |
T4870 | 1989-1997 | NN | denotes | germline |
T4871 | 1998-2007 | NN | denotes | sequences |
T4872 | 2008-2010 | IN | denotes | in |
T4873 | 2011-2014 | DT | denotes | the |
T4874 | 2015-2018 | NN | denotes | IgE |
T4875 | 2019-2024 | JJ | denotes | heavy |
T4876 | 2025-2030 | NN | denotes | chain |
T4877 | 2031-2036 | NN | denotes | locus |
T4878 | 2037-2038 | -LRB- | denotes | [ |
T4879 | 2038-2040 | CD | denotes | 13 |
T4880 | 2040-2041 | -RRB- | denotes | ] |
T4881 | 2043-2045 | TO | denotes | To |
T4882 | 2046-2055 | VB | denotes | determine |
T4883 | 2056-2063 | IN | denotes | whether |
T4884 | 2064-2068 | NN | denotes | HOIP |
T4885 | 2069-2071 | VB | denotes | is |
T4886 | 2072-2080 | VB | denotes | required |
T4887 | 2081-2083 | IN | denotes | in |
T4888 | 2084-2087 | DT | denotes | the |
T4889 | 2088-2098 | NN | denotes | initiation |
T4890 | 2099-2101 | IN | denotes | of |
T4891 | 2102-2105 | DT | denotes | the |
T4892 | 2106-2111 | NN | denotes | class |
T4893 | 2112-2121 | NN | denotes | switching |
T4894 | 2122-2129 | NN | denotes | process |
T4895 | 2129-2130 | -COMMA- | denotes | , |
T4896 | 2131-2134 | DT | denotes | the |
T4897 | 2135-2143 | JJ | denotes | relevant |
T4898 | 2144-2145 | NN | denotes | B |
T4899 | 2146-2150 | NN | denotes | cell |
T4900 | 2151-2156 | NN | denotes | lines |
T4901 | 2157-2161 | VB | denotes | were |
T4902 | 2162-2172 | VB | denotes | stimulated |
T4903 | 2173-2180 | IN | denotes | through |
T4904 | 2181-2185 | NN | denotes | CD40 |
T4905 | 2186-2188 | IN | denotes | in |
T4906 | 2189-2192 | DT | denotes | the |
T4907 | 2193-2201 | NN | denotes | presence |
T4908 | 2202-2204 | IN | denotes | of |
T4909 | 2205-2209 | NN | denotes | IL-4 |
T4910 | 2210-2213 | CC | denotes | and |
T4911 | 2214-2220 | VB | denotes | tested |
T4912 | 2221-2224 | IN | denotes | for |
T4913 | 2225-2235 | NN | denotes | production |
T4914 | 2236-2238 | IN | denotes | of |
T4915 | 2239-2247 | NN | denotes | germline |
T4916 | 2248-2255 | NN | denotes | epsilon |
T4917 | 2256-2257 | -LRB- | denotes | ( |
T4918 | 2257-2260 | NN | denotes | GLε |
T4919 | 2260-2261 | -RRB- | denotes | ) |
T4920 | 2262-2273 | NN | denotes | transcripts |
T4921 | 2274-2275 | -LRB- | denotes | ( |
T4922 | 2275-2279 | NN | denotes | Fig. |
T4923 | 2280-2281 | CD | denotes | 3 |
T4924 | 2281-2282 | -RRB- | denotes | ) |
T4925 | 2284-2293 | JJ | denotes | Anti-CD40 |
T4926 | 2294-2302 | NN | denotes | antibody |
T4927 | 2303-2314 | NN | denotes | stimulation |
T4928 | 2315-2320 | RB | denotes | alone |
T4929 | 2321-2323 | CC | denotes | or |
T4930 | 2324-2332 | RB | denotes | together |
T4931 | 2333-2337 | IN | denotes | with |
T4932 | 2338-2342 | NN | denotes | IL-4 |
T4933 | 2343-2350 | VB | denotes | induced |
T4934 | 2351-2354 | NN | denotes | GLε |
T4935 | 2355-2368 | NN | denotes | transcription |
T4936 | 2369-2371 | IN | denotes | in |
T4937 | 2372-2380 | JJ | denotes | parental |
T4938 | 2381-2387 | NN | denotes | A20.2J |
T4939 | 2388-2393 | NN | denotes | cells |
T4940 | 2394-2396 | IN | denotes | as |
T4941 | 2397-2405 | VB | denotes | expected |
T4942 | 2407-2409 | IN | denotes | In |
T4943 | 2410-2418 | NN | denotes | contrast |
T4944 | 2418-2419 | -COMMA- | denotes | , |
T4945 | 2420-2424 | RB | denotes | only |
T4946 | 2425-2428 | JJ | denotes | low |
T4947 | 2429-2435 | NN | denotes | levels |
T4948 | 2436-2438 | IN | denotes | of |
T4949 | 2439-2442 | NN | denotes | GLε |
T4950 | 2443-2453 | NN | denotes | expression |
T4951 | 2454-2458 | VB | denotes | were |
T4952 | 2459-2467 | VB | denotes | detected |
T4953 | 2468-2470 | IN | denotes | in |
T4954 | 2471-2485 | JJ | denotes | HOIP-deficient |
T4955 | 2486-2491 | NN | denotes | cells |
T4956 | 2492-2502 | VB | denotes | stimulated |
T4957 | 2503-2507 | IN | denotes | with |
T4958 | 2508-2514 | CC | denotes | either |
T4959 | 2515-2524 | JJ | denotes | anti-CD40 |
T4960 | 2525-2533 | NN | denotes | antibody |
T4961 | 2534-2539 | RB | denotes | alone |
T4962 | 2540-2542 | CC | denotes | or |
T4963 | 2543-2552 | NN | denotes | anti-CD40 |
T4964 | 2553-2556 | CC | denotes | and |
T4965 | 2557-2561 | NN | denotes | IL-4 |
T4966 | 2563-2569 | JJ | denotes | Normal |
T4967 | 2570-2576 | NN | denotes | levels |
T4968 | 2577-2579 | IN | denotes | of |
T4969 | 2580-2583 | NN | denotes | GLε |
T4970 | 2584-2594 | NN | denotes | expression |
T4971 | 2595-2599 | VB | denotes | were |
T4972 | 2600-2607 | VB | denotes | induced |
T4973 | 2608-2610 | IN | denotes | in |
T4974 | 2611-2629 | JJ | denotes | HOIP-reconstituted |
T4975 | 2630-2635 | NN | denotes | cells |
T4976 | 2636-2646 | VB | denotes | stimulated |
T4977 | 2647-2651 | IN | denotes | with |
T4978 | 2652-2661 | JJ | denotes | anti-CD40 |
T4979 | 2662-2670 | NN | denotes | antibody |
T4980 | 2671-2676 | RB | denotes | alone |
T4981 | 2677-2679 | CC | denotes | or |
T4982 | 2680-2688 | RB | denotes | together |
T4983 | 2689-2693 | IN | denotes | with |
T4984 | 2694-2698 | NN | denotes | IL-4 |
T4985 | 2700-2712 | RB | denotes | Collectively |
T4986 | 2712-2713 | -COMMA- | denotes | , |
T4987 | 2714-2719 | DT | denotes | these |
T4988 | 2720-2724 | NN | denotes | data |
T4989 | 2725-2736 | VB | denotes | demonstrate |
T4990 | 2737-2741 | IN | denotes | that |
T4991 | 2742-2746 | NN | denotes | HOIP |
T4992 | 2747-2750 | VB | denotes | has |
T4993 | 2751-2752 | DT | denotes | a |
T4994 | 2753-2761 | JJ | denotes | critical |
T4995 | 2762-2766 | NN | denotes | role |
T4996 | 2767-2769 | IN | denotes | in |
T4997 | 2770-2778 | JJ | denotes | cellular |
T4998 | 2779-2788 | NN | denotes | responses |
T4999 | 2789-2791 | TO | denotes | to |
T5000 | 2792-2796 | NN | denotes | CD40 |
T5001 | 2797-2806 | NN | denotes | signaling |
T15490 | 850-863 | JJ | denotes | CD40-mediated |
T15491 | 864-868 | NN | denotes | CD80 |
T15492 | 869-881 | NN | denotes | upregulation |
T15493 | 882-884 | VB | denotes | is |
T15494 | 885-894 | JJ | denotes | defective |
T15495 | 895-897 | IN | denotes | in |
T15496 | 898-912 | JJ | denotes | HOIP-deficient |
T15497 | 913-918 | NN | denotes | cells |
T15498 | 920-925 | NN | denotes | Cells |
T15499 | 926-930 | VB | denotes | were |
T15500 | 931-940 | VB | denotes | incubated |
T15501 | 941-944 | IN | denotes | for |
T15502 | 945-947 | CD | denotes | 72 |
T15503 | 948-951 | NN | denotes | hrs |
T15504 | 952-956 | IN | denotes | with |
T15505 | 957-959 | DT | denotes | an |
T15506 | 960-967 | NN | denotes | isotype |
T15507 | 968-975 | NN | denotes | control |
T15508 | 976-984 | NN | denotes | antibody |
T15509 | 985-986 | -LRB- | denotes | ( |
T15510 | 986-990 | JJ | denotes | left |
T15511 | 990-991 | -RRB- | denotes | ) |
T15512 | 992-994 | CC | denotes | or |
T15513 | 995-1004 | JJ | denotes | anti-CD40 |
T15514 | 1005-1013 | NN | denotes | antibody |
T15515 | 1014-1015 | -LRB- | denotes | ( |
T15516 | 1015-1020 | NN | denotes | right |
T15517 | 1020-1021 | -RRB- | denotes | ) |
T15518 | 1022-1025 | CC | denotes | and |
T15519 | 1026-1030 | RB | denotes | then |
T15520 | 1031-1038 | VB | denotes | stained |
T15521 | 1039-1042 | IN | denotes | for |
T15522 | 1043-1053 | NN | denotes | expression |
T15523 | 1054-1056 | IN | denotes | of |
T15524 | 1057-1061 | NN | denotes | CD80 |
T15525 | 1062-1063 | -LRB- | denotes | ( |
T15526 | 1063-1069 | VB | denotes | filled |
T15527 | 1070-1078 | NN | denotes | profiles |
T15528 | 1079-1087 | VB | denotes | indicate |
T15529 | 1088-1096 | NN | denotes | staining |
T15530 | 1097-1101 | IN | denotes | with |
T15531 | 1102-1111 | JJ | denotes | anti-CD80 |
T15532 | 1112-1120 | NN | denotes | antibody |
T15533 | 1120-1121 | -COLON- | denotes | ; |
T15534 | 1122-1126 | JJ | denotes | open |
T15535 | 1127-1135 | NN | denotes | profiles |
T15536 | 1136-1139 | VB | denotes | are |
T15537 | 1140-1148 | VB | denotes | staining |
T15538 | 1149-1153 | IN | denotes | with |
T15539 | 1154-1156 | DT | denotes | an |
T15540 | 1157-1164 | NN | denotes | isotype |
T15541 | 1165-1172 | NN | denotes | control |
T15542 | 1173-1181 | NN | denotes | antibody |
T15543 | 1181-1182 | -RRB- | denotes | ) |
T15544 | 1184-1196 | NN | denotes | Transduction |
T15545 | 1197-1199 | IN | denotes | of |
T15546 | 1200-1204 | CC | denotes | both |
T15547 | 1205-1219 | JJ | denotes | HOIP-deficient |
T15548 | 1220-1221 | -LRB- | denotes | ( |
T15549 | 1221-1228 | JJ | denotes | HOIP-/- |
T15550 | 1228-1229 | -RRB- | denotes | ) |
T15551 | 1230-1236 | NN | denotes | clones |
T15552 | 1237-1241 | IN | denotes | with |
T15553 | 1242-1243 | DT | denotes | a |
T15554 | 1244-1254 | NN | denotes | retrovirus |
T15555 | 1255-1263 | VB | denotes | encoding |
T15556 | 1264-1273 | NN | denotes | FLAG-HOIP |
T15557 | 1274-1282 | VB | denotes | reversed |
T15558 | 1283-1292 | JJ | denotes | defective |
T15559 | 1293-1297 | NN | denotes | CD80 |
T15560 | 1298-1310 | NN | denotes | upregulation |
T15561 | 1310-1311 | -COMMA- | denotes | , |
T15562 | 1312-1317 | IN | denotes | while |
T15563 | 1318-1330 | NN | denotes | transduction |
T15564 | 1331-1335 | IN | denotes | with |
T15565 | 1336-1338 | DT | denotes | an |
T15566 | 1339-1344 | JJ | denotes | empty |
T15567 | 1345-1351 | NN | denotes | vector |
T15568 | 1352-1353 | -LRB- | denotes | ( |
T15569 | 1353-1357 | NN | denotes | pMIP |
T15570 | 1357-1358 | -RRB- | denotes | ) |
T15571 | 1359-1362 | VB | denotes | did |
T15572 | 1363-1366 | RB | denotes | not |
T15573 | 1368-1375 | JJ | denotes | Similar |
T15574 | 1376-1383 | NN | denotes | results |
T15575 | 1384-1388 | VB | denotes | were |
T15576 | 1389-1397 | VB | denotes | obtained |
T15577 | 1398-1400 | IN | denotes | in |
T15578 | 1401-1402 | DT | denotes | a |
T15579 | 1403-1409 | JJ | denotes | second |
T15580 | 1410-1420 | NN | denotes | experiment |
T15889 | 2852-2855 | NN | denotes | GLε |
T15890 | 2856-2869 | NN | denotes | transcription |
T15891 | 2870-2872 | VB | denotes | is |
T15892 | 2873-2882 | JJ | denotes | defective |
T15893 | 2883-2885 | IN | denotes | in |
T15894 | 2886-2901 | JJ | denotes | CD40-stimulated |
T15895 | 2902-2916 | JJ | denotes | HOIP-deficient |
T15896 | 2917-2922 | NN | denotes | cells |
T15897 | 2924-2930 | NN | denotes | A20.2J |
T15898 | 2931-2934 | CC | denotes | and |
T15899 | 2935-2949 | JJ | denotes | HOIP-deficient |
T15900 | 2950-2955 | NN | denotes | cells |
T15901 | 2956-2966 | VB | denotes | transduced |
T15902 | 2967-2971 | IN | denotes | with |
T15903 | 2972-2974 | DT | denotes | an |
T15904 | 2975-2980 | JJ | denotes | empty |
T15905 | 2981-2991 | JJ | denotes | retroviral |
T15906 | 2992-2998 | NN | denotes | vector |
T15907 | 2999-3000 | -LRB- | denotes | ( |
T15908 | 3000-3006 | NN | denotes | A20.2J |
T15909 | 3007-3008 | SYM | denotes | + |
T15910 | 3009-3013 | NN | denotes | pMIP |
T15911 | 3014-3017 | CC | denotes | and |
T15912 | 3018-3025 | JJ | denotes | HOIP-/- |
T15913 | 3026-3027 | SYM | denotes | + |
T15914 | 3028-3032 | NN | denotes | pMIP |
T15915 | 3032-3033 | -COMMA- | denotes | , |
T15916 | 3034-3046 | RB | denotes | respectively |
T15917 | 3046-3047 | -RRB- | denotes | ) |
T15918 | 3047-3048 | -COMMA- | denotes | , |
T15919 | 3049-3051 | CC | denotes | or |
T15920 | 3052-3066 | JJ | denotes | HOIP-deficient |
T15921 | 3067-3072 | NN | denotes | cells |
T15922 | 3073-3083 | VB | denotes | transduced |
T15923 | 3084-3088 | IN | denotes | with |
T15924 | 3089-3090 | DT | denotes | a |
T15925 | 3091-3104 | JJ | denotes | HOIP-encoding |
T15926 | 3105-3115 | NN | denotes | retrovirus |
T15927 | 3116-3117 | -LRB- | denotes | ( |
T15928 | 3117-3124 | JJ | denotes | HOIP-/- |
T15929 | 3125-3126 | SYM | denotes | + |
T15930 | 3127-3131 | NN | denotes | HOIP |
T15931 | 3131-3132 | -RRB- | denotes | ) |
T15932 | 3133-3137 | VB | denotes | were |
T15933 | 3138-3146 | VB | denotes | cultured |
T15934 | 3147-3156 | RB | denotes | overnight |
T15935 | 3157-3161 | IN | denotes | with |
T15936 | 3162-3171 | JJ | denotes | agonistic |
T15937 | 3172-3181 | NN | denotes | anti-CD40 |
T15938 | 3182-3184 | CC | denotes | or |
T15939 | 3185-3187 | DT | denotes | an |
T15940 | 3188-3195 | NN | denotes | isotype |
T15941 | 3196-3203 | NN | denotes | control |
T15942 | 3204-3212 | NN | denotes | antibody |
T15943 | 3213-3214 | -LRB- | denotes | ( |
T15944 | 3214-3217 | NN | denotes | iso |
T15945 | 3217-3218 | -RRB- | denotes | ) |
T15946 | 3218-3219 | -COMMA- | denotes | , |
T15947 | 3220-3224 | IN | denotes | with |
T15948 | 3225-3227 | CC | denotes | or |
T15949 | 3228-3235 | IN | denotes | without |
T15950 | 3236-3240 | NN | denotes | IL-4 |
T15951 | 3242-3245 | NN | denotes | RNA |
T15952 | 3246-3249 | VB | denotes | was |
T15953 | 3250-3258 | VB | denotes | isolated |
T15954 | 3259-3263 | IN | denotes | from |
T15955 | 3264-3267 | DT | denotes | the |
T15956 | 3268-3273 | NN | denotes | cells |
T15957 | 3273-3274 | -COMMA- | denotes | , |
T15958 | 3275-3294 | JJ | denotes | reverse-transcribed |
T15959 | 3294-3295 | -COMMA- | denotes | , |
T15960 | 3296-3299 | CC | denotes | and |
T15961 | 3300-3304 | RB | denotes | then |
T15962 | 3305-3314 | VB | denotes | subjected |
T15963 | 3315-3317 | TO | denotes | to |
T15964 | 3318-3330 | JJ | denotes | quantitative |
T15965 | 3331-3334 | NN | denotes | PCR |
T15966 | 3335-3337 | TO | denotes | to |
T15967 | 3338-3347 | VB | denotes | determine |
T15968 | 3348-3354 | NN | denotes | levels |
T15969 | 3355-3357 | IN | denotes | of |
T15970 | 3358-3361 | NN | denotes | GLε |
T15971 | 3362-3373 | NN | denotes | transcripts |
T15972 | 3375-3382 | NN | denotes | Results |
T15973 | 3383-3387 | VB | denotes | were |
T15974 | 3388-3398 | VB | denotes | normalized |
T15975 | 3399-3401 | TO | denotes | to |
T15976 | 3402-3405 | DT | denotes | the |
T15977 | 3406-3412 | NN | denotes | levels |
T15978 | 3413-3415 | IN | denotes | of |
T15979 | 3416-3421 | NN | denotes | Hprt1 |
T15980 | 3422-3433 | NN | denotes | transcripts |
T15981 | 3434-3436 | IN | denotes | in |
T15982 | 3437-3441 | DT | denotes | each |
T15983 | 3442-3448 | NN | denotes | sample |
T15984 | 3450-3457 | NN | denotes | Symbols |
T15985 | 3458-3466 | VB | denotes | indicate |
T15986 | 3467-3470 | DT | denotes | the |
T15987 | 3471-3477 | NN | denotes | values |
T15988 | 3478-3482 | IN | denotes | from |
T15989 | 3483-3492 | NN | denotes | duplicate |
T15990 | 3493-3501 | NN | denotes | cultures |
T15991 | 3502-3503 | -LRB- | denotes | ( |
T15992 | 3503-3504 | DT | denotes | a |
T15993 | 3505-3509 | NN | denotes | line |
T15994 | 3510-3519 | VB | denotes | indicates |
T15995 | 3520-3523 | DT | denotes | the |
T15996 | 3524-3528 | NN | denotes | mean |
T15997 | 3529-3531 | IN | denotes | of |
T15998 | 3532-3535 | DT | denotes | the |
T15999 | 3536-3539 | CD | denotes | two |
T16000 | 3540-3546 | NN | denotes | values |
T16001 | 3546-3547 | -RRB- | denotes | ) |
T16002 | 3549-3556 | JJ | denotes | Similar |
T16003 | 3557-3564 | NN | denotes | results |
T16004 | 3565-3569 | VB | denotes | were |
T16005 | 3570-3578 | VB | denotes | obtained |
T16006 | 3579-3581 | IN | denotes | in |
T16007 | 3582-3583 | DT | denotes | a |
T16008 | 3584-3590 | JJ | denotes | second |
T16009 | 3591-3601 | NN | denotes | experiment |
T16010 | 3602-3605 | CC | denotes | and |
T16011 | 3606-3608 | IN | denotes | in |
T16012 | 3609-3611 | DT | denotes | an |
T16013 | 3612-3622 | JJ | denotes | additional |
T16014 | 3623-3633 | NN | denotes | experiment |
T16015 | 3634-3638 | IN | denotes | with |
T16016 | 3639-3640 | DT | denotes | a |
T16017 | 3641-3647 | JJ | denotes | second |
T16018 | 3648-3662 | JJ | denotes | HOIP-deficient |
T16019 | 3663-3668 | NN | denotes | clone |
R3629 | T4639 | T4640 | arg1Of | HOIP,is |
R3630 | T4639 | T4641 | arg2Of | HOIP,required |
R3631 | T4641 | T4640 | arg2Of | required,is |
R3632 | T4641 | T4642 | arg1Of | required,for |
R3633 | T4645 | T4643 | arg1Of | upregulation,CD40-mediated |
R3634 | T4645 | T4644 | arg1Of | upregulation,CD80 |
R3635 | T4645 | T4646 | arg1Of | upregulation,and |
R3636 | T4646 | T4642 | arg2Of | and,for |
R3637 | T4647 | T4646 | arg2Of | activation,and |
R3638 | T4647 | T4648 | arg1Of | activation,of |
R3639 | T4651 | T4648 | arg2Of | transcription,of |
R3640 | T4651 | T4649 | arg1Of | transcription,germline |
R3641 | T4651 | T4650 | arg1Of | transcription,epsilon |
R3642 | T4652 | T4653 | arg1Of | Engagement,of |
R3643 | T4652 | T4655 | arg1Of | Engagement,on |
R3644 | T4652 | T4658 | arg1Of | Engagement,upregulates |
R3645 | T4654 | T4653 | arg2Of | CD40,of |
R3646 | T4657 | T4655 | arg2Of | cells,on |
R3647 | T4657 | T4656 | arg1Of | cells,B |
R3648 | T4659 | T4658 | arg2Of | expression,upregulates |
R3649 | T4659 | T4660 | arg1Of | expression,of |
R3650 | T4661 | T4660 | arg2Of | CD80,of |
R3651 | T4661 | T4662 | arg1Of | CD80,[ |
R3652 | T4661 | T4665 | arg1Of | CD80,"," |
R3653 | T4663 | T4662 | arg2Of | 10,[ |
R3654 | T4664 | T4662 | arg3Of | ],[ |
R3655 | T4669 | T4665 | arg2Of | protein,"," |
R3656 | T4669 | T4666 | arg1Of | protein,a |
R3657 | T4669 | T4667 | arg1Of | protein,cell |
R3658 | T4669 | T4668 | arg1Of | protein,surface |
R3659 | T4669 | T4670 | arg1Of | protein,that |
R3660 | T4669 | T4671 | arg1Of | protein,promotes |
R3661 | T4672 | T4673 | arg1Of | activation,of |
R3662 | T4672 | T4680 | arg1Of | activation,and |
R3663 | T4675 | T4673 | arg2Of | cells,of |
R3664 | T4675 | T4674 | arg1Of | cells,T |
R3665 | T4675 | T4676 | arg1Of | cells,interacting |
R3666 | T4676 | T4677 | arg1Of | interacting,with |
R3667 | T4679 | T4677 | arg2Of | cells,with |
R3668 | T4679 | T4678 | arg1Of | cells,B |
R3669 | T4680 | T4671 | arg2Of | and,promotes |
R3670 | T4682 | T4680 | arg2Of | APC,and |
R3671 | T4682 | T4681 | arg1Of | APC,other |
R3672 | T4684 | T4683 | arg1Of | begin,To |
R3673 | T4685 | T4684 | arg2Of | evaluating,begin |
R3674 | T4687 | T4685 | arg2Of | contributions,evaluating |
R3675 | T4687 | T4686 | arg1Of | contributions,potential |
R3676 | T4687 | T4688 | arg1Of | contributions,of |
R3677 | T4689 | T4688 | arg2Of | HOIP,of |
R3678 | T4689 | T4690 | arg1Of | HOIP,to |
R3679 | T4692 | T4690 | arg2Of | signaling,to |
R3680 | T4692 | T4691 | arg1Of | signaling,CD40 |
R3681 | T4694 | T4684 | arg1Of | we,begin |
R3682 | T4694 | T4685 | arg1Of | we,evaluating |
R3683 | T4694 | T4695 | arg1Of | we,assayed |
R3684 | T4695 | T4683 | modOf | assayed,To |
R3685 | T4695 | T4693 | arg1Of | assayed,"," |
R3686 | T4697 | T4695 | arg2Of | upregulation,assayed |
R3687 | T4697 | T4696 | arg1Of | upregulation,the |
R3688 | T4697 | T4698 | arg1Of | upregulation,of |
R3689 | T4699 | T4698 | arg2Of | CD80,of |
R3690 | T4699 | T4700 | arg2Of | CD80,induced |
R3691 | T4702 | T4700 | arg1Of | engagement,induced |
R3692 | T4702 | T4701 | arg2Of | engagement,by |
R3693 | T4702 | T4703 | arg1Of | engagement,of |
R3694 | T4704 | T4703 | arg2Of | CD40,of |
R3695 | T4704 | T4705 | arg1Of | CD40,on |
R3696 | T4707 | T4708 | arg1Of | A20.2J,"," |
R3697 | T4709 | T4711 | arg1Of | HOIP-deficient,and |
R3698 | T4711 | T4708 | arg2Of | and,"," |
R3699 | T4711 | T4710 | arg1Of | and,"," |
R3700 | T4712 | T4711 | arg2Of | HOIP-reconstituted,and |
R3701 | T4713 | T4705 | arg2Of | cells,on |
R3702 | T4713 | T4706 | arg1Of | cells,parental |
R3703 | T4713 | T4707 | arg1Of | cells,A20.2J |
R3704 | T4713 | T4709 | arg1Of | cells,HOIP-deficient |
R3705 | T4713 | T4712 | arg1Of | cells,HOIP-reconstituted |
R3706 | T4713 | T4714 | arg1Of | cells,( |
R3707 | T4715 | T4714 | arg2Of | Fig.,( |
R3708 | T4715 | T4716 | arg1Of | Fig.,2 |
R3709 | T4717 | T4714 | arg3Of | ),( |
R3710 | T4719 | T4718 | arg2Of | to,Compared |
R3711 | T4723 | T4719 | arg2Of | line,to |
R3712 | T4723 | T4720 | arg1Of | line,the |
R3713 | T4723 | T4721 | arg1Of | line,parental |
R3714 | T4723 | T4722 | arg1Of | line,cell |
R3715 | T4727 | T4725 | arg1Of | upregulation,the |
R3716 | T4727 | T4726 | arg1Of | upregulation,CD40-stimulated |
R3717 | T4727 | T4728 | arg1Of | upregulation,of |
R3718 | T4727 | T4730 | arg1Of | upregulation,was |
R3719 | T4727 | T4732 | arg2Of | upregulation,reduced |
R3720 | T4729 | T4728 | arg2Of | CD80,of |
R3721 | T4732 | T4718 | arg1Of | reduced,Compared |
R3722 | T4732 | T4724 | arg1Of | reduced,"," |
R3723 | T4732 | T4730 | arg2Of | reduced,was |
R3724 | T4732 | T4731 | arg1Of | reduced,dramatically |
R3725 | T4732 | T4733 | arg1Of | reduced,in |
R3726 | T4736 | T4733 | arg2Of | cells,in |
R3727 | T4736 | T4734 | arg1Of | cells,all |
R3728 | T4736 | T4735 | arg1Of | cells,HOIP-deficient |
R3729 | T4736 | T4737 | arg2Of | cells,tested |
R3730 | T4739 | T4738 | arg2Of | contrast,In |
R3731 | T4741 | T4742 | arg1Of | upregulation,of |
R3732 | T4741 | T4744 | arg1Of | upregulation,was |
R3733 | T4741 | T4745 | arg2Of | upregulation,restored |
R3734 | T4743 | T4742 | arg2Of | CD80,of |
R3735 | T4745 | T4738 | arg1Of | restored,In |
R3736 | T4745 | T4740 | arg1Of | restored,"," |
R3737 | T4745 | T4744 | arg2Of | restored,was |
R3738 | T4745 | T4746 | arg1Of | restored,in |
R3739 | T4745 | T4749 | arg1Of | restored,"," |
R3740 | T4745 | T4750 | modOf | restored,confirming |
R3741 | T4748 | T4746 | arg2Of | cells,in |
R3742 | T4748 | T4747 | arg1Of | cells,HOIP-reconstituted |
R3743 | T4753 | T4752 | arg1Of | defect,the |
R3744 | T4753 | T4754 | arg1Of | defect,in |
R3745 | T4753 | T4757 | arg1Of | defect,in |
R3746 | T4753 | T4761 | arg1Of | defect,was |
R3747 | T4753 | T4762 | arg1Of | defect,due |
R3748 | T4756 | T4754 | arg2Of | upregulation,in |
R3749 | T4756 | T4755 | arg1Of | upregulation,CD80 |
R3750 | T4760 | T4757 | arg2Of | cells,in |
R3751 | T4760 | T4758 | arg1Of | cells,the |
R3752 | T4760 | T4759 | arg1Of | cells,HOIP-deficient |
R3753 | T4761 | T4750 | arg2Of | was,confirming |
R3754 | T4761 | T4751 | arg1Of | was,that |
R3755 | T4762 | T4761 | arg2Of | due,was |
R3756 | T4762 | T4763 | arg1Of | due,to |
R3757 | T4765 | T4763 | arg2Of | disruption,to |
R3758 | T4765 | T4764 | arg1Of | disruption,the |
R3759 | T4765 | T4766 | arg1Of | disruption,of |
R3760 | T4767 | T4766 | arg2Of | Rnf31,of |
R3761 | T4769 | T4768 | arg1Of | signals,CD40 |
R3762 | T4769 | T4770 | arg1Of | signals,in |
R3763 | T4769 | T4773 | arg1Of | signals,can |
R3764 | T4769 | T4775 | arg1Of | signals,contribute |
R3765 | T4772 | T4770 | arg2Of | cells,in |
R3766 | T4772 | T4771 | arg1Of | cells,B |
R3767 | T4775 | T4773 | arg2Of | contribute,can |
R3768 | T4775 | T4774 | arg1Of | contribute,also |
R3769 | T4775 | T4776 | arg1Of | contribute,to |
R3770 | T4775 | T4791 | arg1Of | contribute,"," |
R3771 | T4775 | T4792 | arg1Of | contribute,[ |
R3772 | T4778 | T4776 | arg2Of | activation,to |
R3773 | T4778 | T4777 | arg1Of | activation,the |
R3774 | T4778 | T4779 | arg1Of | activation,of |
R3775 | T4778 | T4782 | arg1Of | activation,in |
R3776 | T4781 | T4779 | arg2Of | recombination,of |
R3777 | T4781 | T4780 | arg1Of | recombination,DNA |
R3778 | T4787 | T4782 | arg2Of | locus,in |
R3779 | T4787 | T4783 | arg1Of | locus,the |
R3780 | T4787 | T4784 | arg1Of | locus,immunoglobulin |
R3781 | T4787 | T4785 | arg1Of | locus,heavy |
R3782 | T4787 | T4786 | arg1Of | locus,chain |
R3783 | T4787 | T4788 | arg1Of | locus,[ |
R3784 | T4789 | T4788 | arg2Of | 11,[ |
R3785 | T4790 | T4788 | arg3Of | ],[ |
R3786 | T4793 | T4792 | arg2Of | 12,[ |
R3787 | T4794 | T4792 | arg3Of | ],[ |
R3788 | T4796 | T4795 | arg1Of | process,This |
R3789 | T4796 | T4797 | arg1Of | process,"," |
R3790 | T4796 | T4798 | arg2Of | process,known |
R3791 | T4796 | T4809 | arg1Of | process,allows |
R3792 | T4796 | T4814 | arg1Of | process,expressing |
R3793 | T4798 | T4799 | arg1Of | known,as |
R3794 | T4802 | T4799 | arg2Of | switching,as |
R3795 | T4802 | T4800 | arg1Of | switching,immunoglobulin |
R3796 | T4802 | T4801 | arg1Of | switching,class |
R3797 | T4802 | T4803 | arg1Of | switching,( |
R3798 | T4806 | T4803 | arg2Of | switching,( |
R3799 | T4806 | T4804 | arg1Of | switching,or |
R3800 | T4806 | T4805 | arg1Of | switching,isotype |
R3801 | T4807 | T4803 | arg3Of | ),( |
R3802 | T4809 | T4808 | arg1Of | allows,"," |
R3803 | T4809 | T4812 | arg1Of | allows,"," |
R3804 | T4809 | T4814 | modOf | allows,expressing |
R3805 | T4811 | T4809 | arg2Of | cells,allows |
R3806 | T4811 | T4810 | arg1Of | cells,B |
R3807 | T4814 | T4813 | arg1Of | expressing,initially |
R3808 | T4814 | T4817 | modOf | expressing,to |
R3809 | T4815 | T4814 | arg2Of | IgM,expressing |
R3810 | T4815 | T4833 | arg1Of | IgM,appropriate |
R3811 | T4818 | T4816 | arg1Of | switch,"," |
R3812 | T4818 | T4817 | arg1Of | switch,to |
R3813 | T4818 | T4819 | arg1Of | switch,to |
R3814 | T4818 | T4826 | arg1Of | switch,depending |
R3815 | T4820 | T4821 | arg1Of | IgA,"," |
R3816 | T4821 | T4824 | arg1Of | ",",or |
R3817 | T4822 | T4821 | arg2Of | IgG,"," |
R3818 | T4824 | T4819 | arg2Of | or,to |
R3819 | T4824 | T4823 | arg1Of | or,"," |
R3820 | T4825 | T4824 | arg2Of | IgE,or |
R3821 | T4827 | T4826 | arg2Of | on,depending |
R3822 | T4829 | T4827 | arg2Of | class,on |
R3823 | T4829 | T4828 | arg1Of | class,the |
R3824 | T4829 | T4830 | arg1Of | class,of |
R3825 | T4831 | T4830 | arg2Of | antibody,of |
R3826 | T4833 | T4814 | arg3Of | appropriate,expressing |
R3827 | T4833 | T4832 | arg1Of | appropriate,most |
R3828 | T4833 | T4834 | arg1Of | appropriate,for |
R3829 | T4838 | T4834 | arg2Of | response,for |
R3830 | T4838 | T4835 | arg1Of | response,a |
R3831 | T4838 | T4836 | arg1Of | response,particular |
R3832 | T4838 | T4837 | arg1Of | response,immune |
R3833 | T4839 | T4840 | arg1Of | Switching,to |
R3834 | T4839 | T4842 | arg1Of | Switching,can |
R3835 | T4839 | T4843 | arg1Of | Switching,be |
R3836 | T4839 | T4844 | arg2Of | Switching,induced |
R3837 | T4841 | T4840 | arg2Of | IgE,to |
R3838 | T4844 | T4842 | arg2Of | induced,can |
R3839 | T4844 | T4843 | arg2Of | induced,be |
R3840 | T4847 | T4844 | arg1Of | combination,induced |
R3841 | T4847 | T4845 | arg2Of | combination,by |
R3842 | T4847 | T4846 | arg1Of | combination,the |
R3843 | T4847 | T4848 | arg1Of | combination,of |
R3844 | T4849 | T4850 | arg1Of | IL-4,and |
R3845 | T4851 | T4850 | arg2Of | CD40,and |
R3846 | T4852 | T4848 | arg2Of | signals,of |
R3847 | T4852 | T4849 | arg1Of | signals,IL-4 |
R3848 | T4852 | T4851 | arg1Of | signals,CD40 |
R3849 | T4855 | T4853 | arg1Of | rearrangement,The |
R3850 | T4855 | T4854 | arg1Of | rearrangement,gene |
R3851 | T4855 | T4856 | arg1Of | rearrangement,necessary |
R3852 | T4855 | T4860 | arg1Of | rearrangement,is |
R3853 | T4855 | T4861 | arg2Of | rearrangement,preceded |
R3854 | T4856 | T4857 | arg1Of | necessary,for |
R3855 | T4859 | T4857 | arg2Of | production,for |
R3856 | T4859 | T4858 | arg1Of | production,IgE |
R3857 | T4861 | T4860 | arg2Of | preceded,is |
R3858 | T4864 | T4861 | arg1Of | production,preceded |
R3859 | T4864 | T4862 | arg2Of | production,by |
R3860 | T4864 | T4863 | arg1Of | production,the |
R3861 | T4864 | T4865 | arg1Of | production,of |
R3862 | T4868 | T4865 | arg2Of | transcripts,of |
R3863 | T4868 | T4866 | arg1Of | transcripts,non-coding |
R3864 | T4868 | T4867 | arg1Of | transcripts,RNA |
R3865 | T4868 | T4869 | arg1Of | transcripts,from |
R3866 | T4871 | T4869 | arg2Of | sequences,from |
R3867 | T4871 | T4870 | arg1Of | sequences,germline |
R3868 | T4871 | T4872 | arg1Of | sequences,in |
R3869 | T4877 | T4872 | arg2Of | locus,in |
R3870 | T4877 | T4873 | arg1Of | locus,the |
R3871 | T4877 | T4874 | arg1Of | locus,IgE |
R3872 | T4877 | T4875 | arg1Of | locus,heavy |
R3873 | T4877 | T4876 | arg1Of | locus,chain |
R3874 | T4877 | T4878 | arg1Of | locus,[ |
R3875 | T4879 | T4878 | arg2Of | 13,[ |
R3876 | T4880 | T4878 | arg3Of | ],[ |
R3877 | T4882 | T4881 | arg1Of | determine,To |
R3878 | T4884 | T4885 | arg1Of | HOIP,is |
R3879 | T4884 | T4886 | arg2Of | HOIP,required |
R3880 | T4886 | T4882 | arg2Of | required,determine |
R3881 | T4886 | T4883 | arg1Of | required,whether |
R3882 | T4886 | T4885 | arg2Of | required,is |
R3883 | T4886 | T4887 | arg1Of | required,in |
R3884 | T4889 | T4887 | arg2Of | initiation,in |
R3885 | T4889 | T4888 | arg1Of | initiation,the |
R3886 | T4889 | T4890 | arg1Of | initiation,of |
R3887 | T4894 | T4890 | arg2Of | process,of |
R3888 | T4894 | T4891 | arg1Of | process,the |
R3889 | T4894 | T4892 | arg1Of | process,class |
R3890 | T4894 | T4893 | arg1Of | process,switching |
R3891 | T4900 | T4896 | arg1Of | lines,the |
R3892 | T4900 | T4897 | arg1Of | lines,relevant |
R3893 | T4900 | T4898 | arg1Of | lines,B |
R3894 | T4900 | T4899 | arg1Of | lines,cell |
R3895 | T4900 | T4901 | arg1Of | lines,were |
R3896 | T4900 | T4902 | arg2Of | lines,stimulated |
R3897 | T4900 | T4911 | arg2Of | lines,tested |
R3898 | T4902 | T4903 | arg1Of | stimulated,through |
R3899 | T4902 | T4905 | arg1Of | stimulated,in |
R3900 | T4902 | T4910 | arg1Of | stimulated,and |
R3901 | T4904 | T4903 | arg2Of | CD40,through |
R3902 | T4907 | T4905 | arg2Of | presence,in |
R3903 | T4907 | T4906 | arg1Of | presence,the |
R3904 | T4907 | T4908 | arg1Of | presence,of |
R3905 | T4909 | T4908 | arg2Of | IL-4,of |
R3906 | T4910 | T4881 | modOf | and,To |
R3907 | T4910 | T4895 | arg1Of | and,"," |
R3908 | T4910 | T4901 | arg2Of | and,were |
R3909 | T4911 | T4910 | arg2Of | tested,and |
R3910 | T4911 | T4912 | arg1Of | tested,for |
R3911 | T4913 | T4912 | arg2Of | production,for |
R3912 | T4913 | T4914 | arg1Of | production,of |
R3913 | T4916 | T4915 | arg1Of | epsilon,germline |
R3914 | T4916 | T4917 | arg1Of | epsilon,( |
R3915 | T4918 | T4917 | arg2Of | GLε,( |
R3916 | T4919 | T4917 | arg3Of | ),( |
R3917 | T4920 | T4914 | arg2Of | transcripts,of |
R3918 | T4920 | T4916 | arg1Of | transcripts,epsilon |
R3919 | T4920 | T4921 | arg1Of | transcripts,( |
R3920 | T4922 | T4921 | arg2Of | Fig.,( |
R3921 | T4922 | T4923 | arg1Of | Fig.,3 |
R3922 | T4924 | T4921 | arg3Of | ),( |
R3923 | T4927 | T4925 | arg1Of | stimulation,Anti-CD40 |
R3924 | T4927 | T4926 | arg1Of | stimulation,antibody |
R3925 | T4927 | T4928 | arg1Of | stimulation,alone |
R3926 | T4927 | T4930 | arg1Of | stimulation,together |
R3927 | T4927 | T4933 | arg1Of | stimulation,induced |
R3928 | T4928 | T4929 | arg1Of | alone,or |
R3929 | T4929 | T4931 | arg1Of | or,with |
R3930 | T4930 | T4929 | arg2Of | together,or |
R3931 | T4932 | T4931 | arg2Of | IL-4,with |
R3932 | T4935 | T4933 | arg2Of | transcription,induced |
R3933 | T4935 | T4934 | arg1Of | transcription,GLε |
R3934 | T4935 | T4936 | arg1Of | transcription,in |
R3935 | T4939 | T4936 | arg2Of | cells,in |
R3936 | T4939 | T4937 | arg1Of | cells,parental |
R3937 | T4939 | T4938 | arg1Of | cells,A20.2J |
R3938 | T4940 | T4933 | arg3Of | as,induced |
R3939 | T4941 | T4940 | arg2Of | expected,as |
R3940 | T4943 | T4942 | arg2Of | contrast,In |
R3941 | T4947 | T4945 | arg1Of | levels,only |
R3942 | T4947 | T4946 | arg1Of | levels,low |
R3943 | T4947 | T4948 | arg1Of | levels,of |
R3944 | T4947 | T4951 | arg1Of | levels,were |
R3945 | T4947 | T4952 | arg2Of | levels,detected |
R3946 | T4950 | T4948 | arg2Of | expression,of |
R3947 | T4950 | T4949 | arg1Of | expression,GLε |
R3948 | T4952 | T4942 | arg1Of | detected,In |
R3949 | T4952 | T4944 | arg1Of | detected,"," |
R3950 | T4952 | T4951 | arg2Of | detected,were |
R3951 | T4952 | T4953 | arg1Of | detected,in |
R3952 | T4955 | T4953 | arg2Of | cells,in |
R3953 | T4955 | T4954 | arg1Of | cells,HOIP-deficient |
R3954 | T4955 | T4956 | arg2Of | cells,stimulated |
R3955 | T4956 | T4957 | arg1Of | stimulated,with |
R3956 | T4960 | T4959 | arg1Of | antibody,anti-CD40 |
R3957 | T4960 | T4961 | arg1Of | antibody,alone |
R3958 | T4960 | T4962 | arg1Of | antibody,or |
R3959 | T4962 | T4957 | arg2Of | or,with |
R3960 | T4962 | T4958 | arg1Of | or,either |
R3961 | T4963 | T4964 | arg1Of | anti-CD40,and |
R3962 | T4964 | T4962 | arg2Of | and,or |
R3963 | T4965 | T4964 | arg2Of | IL-4,and |
R3964 | T4967 | T4966 | arg1Of | levels,Normal |
R3965 | T4967 | T4968 | arg1Of | levels,of |
R3966 | T4967 | T4971 | arg1Of | levels,were |
R3967 | T4967 | T4972 | arg2Of | levels,induced |
R3968 | T4970 | T4968 | arg2Of | expression,of |
R3969 | T4970 | T4969 | arg1Of | expression,GLε |
R3970 | T4972 | T4971 | arg2Of | induced,were |
R3971 | T4972 | T4973 | arg1Of | induced,in |
R3972 | T4975 | T4973 | arg2Of | cells,in |
R3973 | T4975 | T4974 | arg1Of | cells,HOIP-reconstituted |
R3974 | T4975 | T4976 | arg2Of | cells,stimulated |
R3975 | T4976 | T4977 | arg1Of | stimulated,with |
R3976 | T4979 | T4977 | arg2Of | antibody,with |
R3977 | T4979 | T4978 | arg1Of | antibody,anti-CD40 |
R3978 | T4979 | T4980 | arg1Of | antibody,alone |
R3979 | T4979 | T4982 | arg1Of | antibody,together |
R3980 | T4980 | T4981 | arg1Of | alone,or |
R3981 | T4981 | T4983 | arg1Of | or,with |
R3982 | T4982 | T4981 | arg2Of | together,or |
R3983 | T4984 | T4983 | arg2Of | IL-4,with |
R3984 | T4988 | T4987 | arg1Of | data,these |
R3985 | T4988 | T4989 | arg1Of | data,demonstrate |
R3986 | T4989 | T4985 | arg1Of | demonstrate,Collectively |
R3987 | T4989 | T4986 | arg1Of | demonstrate,"," |
R3988 | T4991 | T4992 | arg1Of | HOIP,has |
R3989 | T4992 | T4989 | arg2Of | has,demonstrate |
R3990 | T4992 | T4990 | arg1Of | has,that |
R3991 | T4992 | T4996 | arg1Of | has,in |
R3992 | T4995 | T4992 | arg2Of | role,has |
R3993 | T4995 | T4993 | arg1Of | role,a |
R3994 | T4995 | T4994 | arg1Of | role,critical |
R3995 | T4998 | T4996 | arg2Of | responses,in |
R3996 | T4998 | T4997 | arg1Of | responses,cellular |
R3997 | T4998 | T4999 | arg1Of | responses,to |
R3998 | T5001 | T4999 | arg2Of | signaling,to |
R3999 | T5001 | T5000 | arg1Of | signaling,CD40 |
R12278 | T15492 | T15490 | arg1Of | upregulation,CD40-mediated |
R12279 | T15492 | T15491 | arg1Of | upregulation,CD80 |
R12280 | T15492 | T15493 | arg1Of | upregulation,is |
R12281 | T15492 | T15494 | arg1Of | upregulation,defective |
R12282 | T15493 | T15495 | arg1Of | is,in |
R12283 | T15494 | T15493 | arg2Of | defective,is |
R12284 | T15497 | T15495 | arg2Of | cells,in |
R12285 | T15497 | T15496 | arg1Of | cells,HOIP-deficient |
R12286 | T15498 | T15499 | arg1Of | Cells,were |
R12287 | T15498 | T15500 | arg2Of | Cells,incubated |
R12288 | T15498 | T15520 | arg2Of | Cells,stained |
R12289 | T15500 | T15501 | arg1Of | incubated,for |
R12290 | T15500 | T15518 | arg1Of | incubated,and |
R12291 | T15503 | T15501 | arg2Of | hrs,for |
R12292 | T15503 | T15502 | arg1Of | hrs,72 |
R12293 | T15503 | T15504 | arg1Of | hrs,with |
R12294 | T15508 | T15506 | arg1Of | antibody,isotype |
R12295 | T15508 | T15507 | arg1Of | antibody,control |
R12296 | T15508 | T15509 | arg1Of | antibody,( |
R12297 | T15508 | T15512 | arg1Of | antibody,or |
R12298 | T15510 | T15509 | arg2Of | left,( |
R12299 | T15511 | T15509 | arg3Of | ),( |
R12300 | T15512 | T15504 | arg2Of | or,with |
R12301 | T15512 | T15505 | arg1Of | or,an |
R12302 | T15514 | T15512 | arg2Of | antibody,or |
R12303 | T15514 | T15513 | arg1Of | antibody,anti-CD40 |
R12304 | T15514 | T15515 | arg1Of | antibody,( |
R12305 | T15516 | T15515 | arg2Of | right,( |
R12306 | T15517 | T15515 | arg3Of | ),( |
R12307 | T15518 | T15499 | arg2Of | and,were |
R12308 | T15520 | T15518 | arg2Of | stained,and |
R12309 | T15520 | T15519 | arg1Of | stained,then |
R12310 | T15520 | T15521 | arg1Of | stained,for |
R12311 | T15522 | T15521 | arg2Of | expression,for |
R12312 | T15522 | T15523 | arg1Of | expression,of |
R12313 | T15524 | T15523 | arg2Of | CD80,of |
R12314 | T15524 | T15525 | arg1Of | CD80,( |
R12315 | T15527 | T15526 | arg2Of | profiles,filled |
R12316 | T15527 | T15528 | arg1Of | profiles,indicate |
R12317 | T15528 | T15525 | arg2Of | indicate,( |
R12318 | T15528 | T15530 | arg1Of | indicate,with |
R12319 | T15528 | T15533 | arg1Of | indicate,; |
R12320 | T15529 | T15528 | arg2Of | staining,indicate |
R12321 | T15532 | T15530 | arg2Of | antibody,with |
R12322 | T15532 | T15531 | arg1Of | antibody,anti-CD80 |
R12323 | T15535 | T15534 | arg1Of | profiles,open |
R12324 | T15535 | T15536 | arg1Of | profiles,are |
R12325 | T15535 | T15537 | arg1Of | profiles,staining |
R12326 | T15537 | T15533 | arg2Of | staining,; |
R12327 | T15537 | T15536 | arg2Of | staining,are |
R12328 | T15537 | T15538 | arg1Of | staining,with |
R12329 | T15542 | T15538 | arg2Of | antibody,with |
R12330 | T15542 | T15539 | arg1Of | antibody,an |
R12331 | T15542 | T15540 | arg1Of | antibody,isotype |
R12332 | T15542 | T15541 | arg1Of | antibody,control |
R12333 | T15543 | T15525 | arg3Of | ),( |
R12334 | T15544 | T15545 | arg1Of | Transduction,of |
R12335 | T15544 | T15557 | arg1Of | Transduction,reversed |
R12336 | T15547 | T15548 | arg1Of | HOIP-deficient,( |
R12337 | T15549 | T15548 | arg2Of | HOIP-/-,( |
R12338 | T15550 | T15548 | arg3Of | ),( |
R12339 | T15551 | T15545 | arg2Of | clones,of |
R12340 | T15551 | T15546 | arg1Of | clones,both |
R12341 | T15551 | T15547 | arg1Of | clones,HOIP-deficient |
R12342 | T15551 | T15552 | arg1Of | clones,with |
R12343 | T15554 | T15552 | arg2Of | retrovirus,with |
R12344 | T15554 | T15553 | arg1Of | retrovirus,a |
R12345 | T15554 | T15555 | arg1Of | retrovirus,encoding |
R12346 | T15556 | T15555 | arg2Of | FLAG-HOIP,encoding |
R12347 | T15557 | T15561 | arg1Of | reversed,"," |
R12348 | T15557 | T15562 | arg1Of | reversed,while |
R12349 | T15560 | T15557 | arg2Of | upregulation,reversed |
R12350 | T15560 | T15558 | arg1Of | upregulation,defective |
R12351 | T15560 | T15559 | arg1Of | upregulation,CD80 |
R12352 | T15563 | T15564 | arg1Of | transduction,with |
R12353 | T15563 | T15571 | arg1Of | transduction,did |
R12354 | T15567 | T15564 | arg2Of | vector,with |
R12355 | T15567 | T15565 | arg1Of | vector,an |
R12356 | T15567 | T15566 | arg1Of | vector,empty |
R12357 | T15567 | T15568 | arg1Of | vector,( |
R12358 | T15569 | T15568 | arg2Of | pMIP,( |
R12359 | T15570 | T15568 | arg3Of | ),( |
R12360 | T15571 | T15562 | arg2Of | did,while |
R12361 | T15571 | T15572 | arg1Of | did,not |
R12362 | T15574 | T15573 | arg1Of | results,Similar |
R12363 | T15574 | T15575 | arg1Of | results,were |
R12364 | T15574 | T15576 | arg2Of | results,obtained |
R12365 | T15576 | T15575 | arg2Of | obtained,were |
R12366 | T15576 | T15577 | arg1Of | obtained,in |
R12367 | T15580 | T15577 | arg2Of | experiment,in |
R12368 | T15580 | T15578 | arg1Of | experiment,a |
R12369 | T15580 | T15579 | arg1Of | experiment,second |
R12576 | T15890 | T15889 | arg1Of | transcription,GLε |
R12577 | T15890 | T15891 | arg1Of | transcription,is |
R12578 | T15890 | T15892 | arg1Of | transcription,defective |
R12579 | T15892 | T15891 | arg2Of | defective,is |
R12580 | T15892 | T15893 | arg1Of | defective,in |
R12581 | T15896 | T15893 | arg2Of | cells,in |
R12582 | T15896 | T15894 | arg1Of | cells,CD40-stimulated |
R12583 | T15896 | T15895 | arg1Of | cells,HOIP-deficient |
R12584 | T15900 | T15897 | arg1Of | cells,A20.2J |
R12585 | T15900 | T15898 | arg1Of | cells,and |
R12586 | T15900 | T15899 | arg1Of | cells,HOIP-deficient |
R12587 | T15900 | T15901 | arg2Of | cells,transduced |
R12588 | T15900 | T15907 | arg1Of | cells,( |
R12589 | T15900 | T15919 | arg1Of | cells,or |
R12590 | T15901 | T15902 | arg1Of | transduced,with |
R12591 | T15906 | T15902 | arg2Of | vector,with |
R12592 | T15906 | T15903 | arg1Of | vector,an |
R12593 | T15906 | T15904 | arg1Of | vector,empty |
R12594 | T15906 | T15905 | arg1Of | vector,retroviral |
R12595 | T15910 | T15908 | arg1Of | pMIP,A20.2J |
R12596 | T15910 | T15909 | arg1Of | pMIP,+ |
R12597 | T15910 | T15911 | arg1Of | pMIP,and |
R12598 | T15912 | T15911 | arg2Of | HOIP-/-,and |
R12599 | T15914 | T15907 | arg2Of | pMIP,( |
R12600 | T15914 | T15910 | arg1Of | pMIP,pMIP |
R12601 | T15914 | T15912 | arg1Of | pMIP,HOIP-/- |
R12602 | T15914 | T15913 | arg1Of | pMIP,+ |
R12603 | T15914 | T15915 | arg1Of | pMIP,"," |
R12604 | T15914 | T15916 | arg1Of | pMIP,respectively |
R12605 | T15917 | T15907 | arg3Of | ),( |
R12606 | T15919 | T15918 | arg1Of | or,"," |
R12607 | T15919 | T15932 | arg1Of | or,were |
R12608 | T15919 | T15933 | arg2Of | or,cultured |
R12609 | T15921 | T15919 | arg2Of | cells,or |
R12610 | T15921 | T15920 | arg1Of | cells,HOIP-deficient |
R12611 | T15921 | T15922 | arg2Of | cells,transduced |
R12612 | T15922 | T15923 | arg1Of | transduced,with |
R12613 | T15926 | T15923 | arg2Of | retrovirus,with |
R12614 | T15926 | T15924 | arg1Of | retrovirus,a |
R12615 | T15926 | T15925 | arg1Of | retrovirus,HOIP-encoding |
R12616 | T15926 | T15927 | arg1Of | retrovirus,( |
R12617 | T15930 | T15927 | arg2Of | HOIP,( |
R12618 | T15930 | T15928 | arg1Of | HOIP,HOIP-/- |
R12619 | T15930 | T15929 | arg1Of | HOIP,+ |
R12620 | T15931 | T15927 | arg3Of | ),( |
R12621 | T15933 | T15932 | arg2Of | cultured,were |
R12622 | T15933 | T15934 | arg1Of | cultured,overnight |
R12623 | T15933 | T15935 | arg1Of | cultured,with |
R12624 | T15933 | T15946 | arg1Of | cultured,"," |
R12625 | T15933 | T15947 | arg1Of | cultured,with |
R12626 | T15933 | T15949 | arg1Of | cultured,without |
R12627 | T15937 | T15936 | arg1Of | anti-CD40,agonistic |
R12628 | T15937 | T15938 | arg1Of | anti-CD40,or |
R12629 | T15938 | T15935 | arg2Of | or,with |
R12630 | T15942 | T15938 | arg2Of | antibody,or |
R12631 | T15942 | T15939 | arg1Of | antibody,an |
R12632 | T15942 | T15940 | arg1Of | antibody,isotype |
R12633 | T15942 | T15941 | arg1Of | antibody,control |
R12634 | T15942 | T15943 | arg1Of | antibody,( |
R12635 | T15944 | T15943 | arg2Of | iso,( |
R12636 | T15945 | T15943 | arg3Of | ),( |
R12637 | T15947 | T15948 | arg1Of | with,or |
R12638 | T15949 | T15948 | arg2Of | without,or |
R12639 | T15950 | T15947 | arg2Of | IL-4,with |
R12640 | T15950 | T15949 | arg2Of | IL-4,without |
R12641 | T15951 | T15952 | arg1Of | RNA,was |
R12642 | T15951 | T15953 | arg2Of | RNA,isolated |
R12643 | T15951 | T15962 | arg2Of | RNA,subjected |
R12644 | T15953 | T15954 | arg1Of | isolated,from |
R12645 | T15953 | T15960 | arg1Of | isolated,and |
R12646 | T15956 | T15954 | arg2Of | cells,from |
R12647 | T15956 | T15955 | arg1Of | cells,the |
R12648 | T15956 | T15957 | arg1Of | cells,"," |
R12649 | T15958 | T15957 | arg2Of | reverse-transcribed,"," |
R12650 | T15960 | T15952 | arg2Of | and,was |
R12651 | T15960 | T15959 | arg1Of | and,"," |
R12652 | T15962 | T15960 | arg2Of | subjected,and |
R12653 | T15962 | T15961 | arg1Of | subjected,then |
R12654 | T15962 | T15963 | arg1Of | subjected,to |
R12655 | T15962 | T15966 | modOf | subjected,to |
R12656 | T15965 | T15963 | arg2Of | PCR,to |
R12657 | T15965 | T15964 | arg1Of | PCR,quantitative |
R12658 | T15967 | T15966 | arg1Of | determine,to |
R12659 | T15968 | T15967 | arg2Of | levels,determine |
R12660 | T15968 | T15969 | arg1Of | levels,of |
R12661 | T15971 | T15969 | arg2Of | transcripts,of |
R12662 | T15971 | T15970 | arg1Of | transcripts,GLε |
R12663 | T15972 | T15973 | arg1Of | Results,were |
R12664 | T15972 | T15974 | arg2Of | Results,normalized |
R12665 | T15974 | T15973 | arg2Of | normalized,were |
R12666 | T15974 | T15975 | arg1Of | normalized,to |
R12667 | T15977 | T15975 | arg2Of | levels,to |
R12668 | T15977 | T15976 | arg1Of | levels,the |
R12669 | T15977 | T15978 | arg1Of | levels,of |
R12670 | T15977 | T15981 | arg1Of | levels,in |
R12671 | T15980 | T15978 | arg2Of | transcripts,of |
R12672 | T15980 | T15979 | arg1Of | transcripts,Hprt1 |
R12673 | T15983 | T15981 | arg2Of | sample,in |
R12674 | T15983 | T15982 | arg1Of | sample,each |
R12675 | T15984 | T15985 | arg1Of | Symbols,indicate |
R12676 | T15985 | T15991 | arg1Of | indicate,( |
R12677 | T15987 | T15985 | arg2Of | values,indicate |
R12678 | T15987 | T15986 | arg1Of | values,the |
R12679 | T15987 | T15988 | arg1Of | values,from |
R12680 | T15990 | T15988 | arg2Of | cultures,from |
R12681 | T15990 | T15989 | arg1Of | cultures,duplicate |
R12682 | T15993 | T15992 | arg1Of | line,a |
R12683 | T15993 | T15994 | arg1Of | line,indicates |
R12684 | T15994 | T15991 | arg2Of | indicates,( |
R12685 | T15996 | T15994 | arg2Of | mean,indicates |
R12686 | T15996 | T15995 | arg1Of | mean,the |
R12687 | T15996 | T15997 | arg1Of | mean,of |
R12688 | T16000 | T15997 | arg2Of | values,of |
R12689 | T16000 | T15998 | arg1Of | values,the |
R12690 | T16000 | T15999 | arg1Of | values,two |
R12691 | T16001 | T15991 | arg3Of | ),( |
R12692 | T16003 | T16002 | arg1Of | results,Similar |
R12693 | T16003 | T16004 | arg1Of | results,were |
R12694 | T16003 | T16005 | arg2Of | results,obtained |
R12695 | T16005 | T16004 | arg2Of | obtained,were |
R12696 | T16005 | T16006 | arg1Of | obtained,in |
R12697 | T16005 | T16011 | arg1Of | obtained,in |
R12698 | T16005 | T16015 | arg1Of | obtained,with |
R12699 | T16006 | T16010 | arg1Of | in,and |
R12700 | T16009 | T16006 | arg2Of | experiment,in |
R12701 | T16009 | T16007 | arg1Of | experiment,a |
R12702 | T16009 | T16008 | arg1Of | experiment,second |
R12703 | T16011 | T16010 | arg2Of | in,and |
R12704 | T16014 | T16011 | arg2Of | experiment,in |
R12705 | T16014 | T16012 | arg1Of | experiment,an |
R12706 | T16014 | T16013 | arg1Of | experiment,additional |
R12707 | T16019 | T16015 | arg2Of | clone,with |
R12708 | T16019 | T16016 | arg1Of | clone,a |
R12709 | T16019 | T16017 | arg1Of | clone,second |
R12710 | T16019 | T16018 | arg1Of | clone,HOIP-deficient |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
21829693-7681471-89653762 | 164-166 | 7681471 | denotes | 10 |
21829693-7681587-89653763 | 1548-1550 | 7681587 | denotes | 11 |
21829693-1701824-89653764 | 1554-1556 | 1701824 | denotes | 12 |
21829693-12949496-89653765 | 2038-2040 | 12949496 | denotes | 13 |
T72061 | 164-166 | 7681471 | denotes | 10 |
T18517 | 1548-1550 | 7681587 | denotes | 11 |
T73302 | 1554-1556 | 1701824 | denotes | 12 |
T513 | 2038-2040 | 12949496 | denotes | 13 |
bionlp-st-ge-2016-spacy-parsed
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T4259 | 0-4 | NNP | denotes | HOIP |
T4260 | 5-7 | VBZ | denotes | is |
T4261 | 8-16 | VBN | denotes | required |
T4262 | 17-20 | IN | denotes | for |
T4263 | 21-34 | JJ | denotes | CD40-mediated |
T4264 | 35-39 | NN | denotes | CD80 |
T4265 | 40-52 | NN | denotes | upregulation |
T4266 | 53-56 | CC | denotes | and |
T4267 | 57-67 | NN | denotes | activation |
T4268 | 68-70 | IN | denotes | of |
T4269 | 71-79 | NN | denotes | germline |
T4270 | 80-87 | NN | denotes | epsilon |
T4271 | 88-101 | NN | denotes | transcription |
T4272 | 102-112 | NNP | denotes | Engagement |
T4273 | 113-115 | IN | denotes | of |
T4274 | 116-120 | NNP | denotes | CD40 |
T4275 | 121-123 | IN | denotes | on |
T4276 | 124-125 | NNP | denotes | B |
T4277 | 126-131 | NNS | denotes | cells |
T4278 | 132-143 | VBZ | denotes | upregulates |
T4279 | 144-154 | NN | denotes | expression |
T4280 | 155-157 | IN | denotes | of |
T4281 | 158-162 | NNP | denotes | CD80 |
T4282 | 163-164 | NNP | denotes | [ |
T4283 | 164-166 | CD | denotes | 10 |
T4284 | 166-167 | NNP | denotes | ] |
T4285 | 167-168 | , | denotes | , |
T4286 | 169-170 | DT | denotes | a |
T4287 | 171-175 | NN | denotes | cell |
T4288 | 176-183 | NN | denotes | surface |
T4289 | 184-191 | NN | denotes | protein |
T4290 | 192-196 | WDT | denotes | that |
T4291 | 197-205 | VBZ | denotes | promotes |
T4292 | 206-216 | NN | denotes | activation |
T4293 | 217-219 | IN | denotes | of |
T4294 | 220-221 | NNP | denotes | T |
T4295 | 222-227 | NNS | denotes | cells |
T4296 | 228-239 | VBG | denotes | interacting |
T4297 | 240-244 | IN | denotes | with |
T4298 | 245-246 | NNP | denotes | B |
T4299 | 247-252 | NNS | denotes | cells |
T4300 | 253-256 | CC | denotes | and |
T4301 | 257-262 | JJ | denotes | other |
T4302 | 263-266 | NNP | denotes | APC |
T4303 | 266-267 | . | denotes | . |
T4304 | 268-270 | TO | denotes | To |
T4305 | 271-276 | VB | denotes | begin |
T4306 | 277-287 | VBG | denotes | evaluating |
T4307 | 288-297 | JJ | denotes | potential |
T4308 | 298-311 | NNS | denotes | contributions |
T4309 | 312-314 | IN | denotes | of |
T4310 | 315-319 | NNP | denotes | HOIP |
T4311 | 320-322 | TO | denotes | to |
T4312 | 323-327 | NNP | denotes | CD40 |
T4313 | 328-337 | VBG | denotes | signaling |
T4314 | 337-338 | , | denotes | , |
T4315 | 339-341 | PRP | denotes | we |
T4316 | 342-349 | VBD | denotes | assayed |
T4317 | 350-353 | DT | denotes | the |
T4318 | 354-366 | NN | denotes | upregulation |
T4319 | 367-369 | IN | denotes | of |
T4320 | 370-374 | CD | denotes | CD80 |
T4321 | 375-382 | VBN | denotes | induced |
T4322 | 383-385 | IN | denotes | by |
T4323 | 386-396 | NN | denotes | engagement |
T4324 | 397-399 | IN | denotes | of |
T4325 | 400-404 | NNP | denotes | CD40 |
T4326 | 405-407 | IN | denotes | on |
T4327 | 408-416 | JJ | denotes | parental |
T4328 | 417-420 | NNP | denotes | A20 |
T4329 | 420-422 | CD | denotes | .2 |
T4330 | 422-423 | NNP | denotes | J |
T4331 | 423-424 | , | denotes | , |
T4332 | 425-439 | NNP | denotes | HOIP-deficient |
T4333 | 439-440 | , | denotes | , |
T4334 | 441-444 | CC | denotes | and |
T4335 | 445-463 | JJ | denotes | HOIP-reconstituted |
T4336 | 464-469 | NNS | denotes | cells |
T4337 | 470-471 | -LRB- | denotes | ( |
T4338 | 471-475 | JJ | denotes | Fig. |
T4339 | 476-477 | CD | denotes | 2 |
T4340 | 477-478 | -RRB- | denotes | ) |
T4341 | 478-479 | . | denotes | . |
T4342 | 480-488 | VBN | denotes | Compared |
T4343 | 489-491 | TO | denotes | to |
T4344 | 492-495 | DT | denotes | the |
T4345 | 496-504 | JJ | denotes | parental |
T4346 | 505-509 | NN | denotes | cell |
T4347 | 510-514 | NN | denotes | line |
T4348 | 514-515 | , | denotes | , |
T4349 | 516-519 | DT | denotes | the |
T4350 | 520-535 | JJ | denotes | CD40-stimulated |
T4351 | 536-548 | NN | denotes | upregulation |
T4352 | 549-551 | IN | denotes | of |
T4353 | 552-556 | NN | denotes | CD80 |
T4354 | 557-560 | VBD | denotes | was |
T4355 | 561-573 | RB | denotes | dramatically |
T4356 | 574-581 | VBN | denotes | reduced |
T4357 | 582-584 | IN | denotes | in |
T4358 | 585-588 | DT | denotes | all |
T4359 | 589-603 | JJ | denotes | HOIP-deficient |
T4360 | 604-609 | NNS | denotes | cells |
T4361 | 610-616 | VBN | denotes | tested |
T4362 | 616-617 | . | denotes | . |
T4363 | 618-620 | IN | denotes | In |
T4364 | 621-629 | NN | denotes | contrast |
T4365 | 629-630 | , | denotes | , |
T4366 | 631-643 | NN | denotes | upregulation |
T4367 | 644-646 | IN | denotes | of |
T4368 | 647-651 | NN | denotes | CD80 |
T4369 | 652-655 | VBD | denotes | was |
T4370 | 656-664 | VBN | denotes | restored |
T4371 | 665-667 | IN | denotes | in |
T4372 | 668-686 | JJ | denotes | HOIP-reconstituted |
T4373 | 687-692 | NNS | denotes | cells |
T4374 | 692-693 | , | denotes | , |
T4375 | 694-704 | VBG | denotes | confirming |
T4376 | 705-709 | IN | denotes | that |
T4377 | 710-713 | DT | denotes | the |
T4378 | 714-720 | NN | denotes | defect |
T4379 | 721-723 | IN | denotes | in |
T4380 | 724-728 | NNP | denotes | CD80 |
T4381 | 729-741 | NN | denotes | upregulation |
T4382 | 742-744 | IN | denotes | in |
T4383 | 745-748 | DT | denotes | the |
T4384 | 749-763 | JJ | denotes | HOIP-deficient |
T4385 | 764-769 | NNS | denotes | cells |
T4386 | 770-773 | VBD | denotes | was |
T4387 | 774-777 | JJ | denotes | due |
T4388 | 778-780 | TO | denotes | to |
T4389 | 781-784 | DT | denotes | the |
T4390 | 785-795 | NN | denotes | disruption |
T4391 | 796-798 | IN | denotes | of |
T4392 | 799-804 | NNP | denotes | Rnf31 |
T4393 | 804-805 | . | denotes | . |
T4394 | 1424-1428 | CD | denotes | CD40 |
T4395 | 1429-1436 | NNS | denotes | signals |
T4396 | 1437-1439 | IN | denotes | in |
T4397 | 1440-1441 | NNP | denotes | B |
T4398 | 1442-1447 | NNS | denotes | cells |
T4399 | 1448-1451 | MD | denotes | can |
T4400 | 1452-1456 | RB | denotes | also |
T4401 | 1457-1467 | VB | denotes | contribute |
T4402 | 1468-1470 | TO | denotes | to |
T4403 | 1471-1474 | DT | denotes | the |
T4404 | 1475-1485 | NN | denotes | activation |
T4405 | 1486-1488 | IN | denotes | of |
T4406 | 1489-1492 | NNP | denotes | DNA |
T4407 | 1493-1506 | NN | denotes | recombination |
T4408 | 1507-1509 | IN | denotes | in |
T4409 | 1510-1513 | DT | denotes | the |
T4410 | 1514-1528 | NN | denotes | immunoglobulin |
T4411 | 1529-1534 | JJ | denotes | heavy |
T4412 | 1535-1540 | NN | denotes | chain |
T4413 | 1541-1546 | NN | denotes | locus |
T4414 | 1547-1548 | NNP | denotes | [ |
T4415 | 1548-1550 | CD | denotes | 11 |
T4416 | 1550-1551 | NNP | denotes | ] |
T4417 | 1551-1552 | , | denotes | , |
T4418 | 1553-1554 | NNP | denotes | [ |
T4419 | 1554-1556 | CD | denotes | 12 |
T4420 | 1556-1557 | NNP | denotes | ] |
T4421 | 1557-1558 | . | denotes | . |
T4422 | 1559-1563 | DT | denotes | This |
T4423 | 1564-1571 | NN | denotes | process |
T4424 | 1571-1572 | , | denotes | , |
T4425 | 1573-1578 | VBN | denotes | known |
T4426 | 1579-1581 | IN | denotes | as |
T4427 | 1582-1596 | JJ | denotes | immunoglobulin |
T4428 | 1597-1602 | NN | denotes | class |
T4429 | 1603-1612 | NN | denotes | switching |
T4430 | 1613-1614 | -LRB- | denotes | ( |
T4431 | 1614-1616 | CC | denotes | or |
T4432 | 1617-1624 | JJ | denotes | isotype |
T4433 | 1625-1634 | NN | denotes | switching |
T4434 | 1634-1635 | -RRB- | denotes | ) |
T4435 | 1635-1636 | , | denotes | , |
T4436 | 1637-1643 | VBZ | denotes | allows |
T4437 | 1644-1645 | NNP | denotes | B |
T4438 | 1646-1651 | NNS | denotes | cells |
T4439 | 1651-1652 | , | denotes | , |
T4440 | 1653-1662 | RB | denotes | initially |
T4441 | 1663-1673 | VBG | denotes | expressing |
T4442 | 1674-1677 | NNP | denotes | IgM |
T4443 | 1677-1678 | , | denotes | , |
T4444 | 1679-1681 | TO | denotes | to |
T4445 | 1682-1688 | VB | denotes | switch |
T4446 | 1689-1691 | TO | denotes | to |
T4447 | 1692-1695 | NNP | denotes | IgA |
T4448 | 1695-1696 | , | denotes | , |
T4449 | 1697-1700 | NNP | denotes | IgG |
T4450 | 1700-1701 | , | denotes | , |
T4451 | 1702-1704 | CC | denotes | or |
T4452 | 1705-1708 | NNP | denotes | IgE |
T4453 | 1709-1718 | VBG | denotes | depending |
T4454 | 1719-1721 | IN | denotes | on |
T4455 | 1722-1725 | DT | denotes | the |
T4456 | 1726-1731 | NN | denotes | class |
T4457 | 1732-1734 | IN | denotes | of |
T4458 | 1735-1743 | NN | denotes | antibody |
T4459 | 1744-1748 | RBS | denotes | most |
T4460 | 1749-1760 | JJ | denotes | appropriate |
T4461 | 1761-1764 | IN | denotes | for |
T4462 | 1765-1766 | DT | denotes | a |
T4463 | 1767-1777 | JJ | denotes | particular |
T4464 | 1778-1784 | JJ | denotes | immune |
T4465 | 1785-1793 | NN | denotes | response |
T4466 | 1793-1794 | . | denotes | . |
T4467 | 1795-1804 | VBG | denotes | Switching |
T4468 | 1805-1807 | TO | denotes | to |
T4469 | 1808-1811 | NNP | denotes | IgE |
T4470 | 1812-1815 | MD | denotes | can |
T4471 | 1816-1818 | VB | denotes | be |
T4472 | 1819-1826 | VBN | denotes | induced |
T4473 | 1827-1829 | IN | denotes | by |
T4474 | 1830-1833 | DT | denotes | the |
T4475 | 1834-1845 | NN | denotes | combination |
T4476 | 1846-1848 | IN | denotes | of |
T4477 | 1849-1853 | NN | denotes | IL-4 |
T4478 | 1854-1857 | CC | denotes | and |
T4479 | 1858-1862 | JJ | denotes | CD40 |
T4480 | 1863-1870 | NNS | denotes | signals |
T4481 | 1870-1871 | . | denotes | . |
T4482 | 1872-1875 | DT | denotes | The |
T4483 | 1876-1880 | NN | denotes | gene |
T4484 | 1881-1894 | NN | denotes | rearrangement |
T4485 | 1895-1904 | JJ | denotes | necessary |
T4486 | 1905-1908 | IN | denotes | for |
T4487 | 1909-1912 | JJ | denotes | IgE |
T4488 | 1913-1923 | NN | denotes | production |
T4489 | 1924-1926 | VBZ | denotes | is |
T4490 | 1927-1935 | VBN | denotes | preceded |
T4491 | 1936-1938 | IN | denotes | by |
T4492 | 1939-1942 | DT | denotes | the |
T4493 | 1943-1953 | NN | denotes | production |
T4494 | 1954-1956 | IN | denotes | of |
T4495 | 1957-1967 | JJ | denotes | non-coding |
T4496 | 1968-1971 | NNP | denotes | RNA |
T4497 | 1972-1983 | NNS | denotes | transcripts |
T4498 | 1984-1988 | IN | denotes | from |
T4499 | 1989-1997 | JJ | denotes | germline |
T4500 | 1998-2007 | NNS | denotes | sequences |
T4501 | 2008-2010 | IN | denotes | in |
T4502 | 2011-2014 | DT | denotes | the |
T4503 | 2015-2018 | NNP | denotes | IgE |
T4504 | 2019-2024 | NN | denotes | heavy |
T4505 | 2025-2030 | NN | denotes | chain |
T4506 | 2031-2036 | VBZ | denotes | locus |
T4507 | 2037-2038 | NNP | denotes | [ |
T4508 | 2038-2040 | CD | denotes | 13 |
T4509 | 2040-2041 | NNP | denotes | ] |
T4510 | 2041-2042 | . | denotes | . |
T4511 | 2043-2045 | TO | denotes | To |
T4512 | 2046-2055 | VB | denotes | determine |
T4513 | 2056-2063 | IN | denotes | whether |
T4514 | 2064-2068 | NNP | denotes | HOIP |
T4515 | 2069-2071 | VBZ | denotes | is |
T4516 | 2072-2080 | VBN | denotes | required |
T4517 | 2081-2083 | IN | denotes | in |
T4518 | 2084-2087 | DT | denotes | the |
T4519 | 2088-2098 | NN | denotes | initiation |
T4520 | 2099-2101 | IN | denotes | of |
T4521 | 2102-2105 | DT | denotes | the |
T4522 | 2106-2111 | NN | denotes | class |
T4523 | 2112-2121 | VBG | denotes | switching |
T4524 | 2122-2129 | NN | denotes | process |
T4525 | 2129-2130 | , | denotes | , |
T4526 | 2131-2134 | DT | denotes | the |
T4527 | 2135-2143 | JJ | denotes | relevant |
T4528 | 2144-2145 | NNP | denotes | B |
T4529 | 2146-2150 | NN | denotes | cell |
T4530 | 2151-2156 | NNS | denotes | lines |
T4531 | 2157-2161 | VBD | denotes | were |
T4532 | 2162-2172 | VBN | denotes | stimulated |
T4533 | 2173-2180 | IN | denotes | through |
T4534 | 2181-2185 | NNP | denotes | CD40 |
T4535 | 2186-2188 | IN | denotes | in |
T4536 | 2189-2192 | DT | denotes | the |
T4537 | 2193-2201 | NN | denotes | presence |
T4538 | 2202-2204 | IN | denotes | of |
T4539 | 2205-2209 | NN | denotes | IL-4 |
T4540 | 2210-2213 | CC | denotes | and |
T4541 | 2214-2220 | VBN | denotes | tested |
T4542 | 2221-2224 | IN | denotes | for |
T4543 | 2225-2235 | NN | denotes | production |
T4544 | 2236-2238 | IN | denotes | of |
T4545 | 2239-2247 | NN | denotes | germline |
T4546 | 2248-2255 | NN | denotes | epsilon |
T4547 | 2256-2257 | -LRB- | denotes | ( |
T4548 | 2257-2260 | NNP | denotes | GLε |
T4549 | 2260-2261 | -RRB- | denotes | ) |
T4550 | 2262-2273 | NNS | denotes | transcripts |
T4551 | 2274-2275 | -LRB- | denotes | ( |
T4552 | 2275-2279 | JJ | denotes | Fig. |
T4553 | 2280-2281 | CD | denotes | 3 |
T4554 | 2281-2282 | -RRB- | denotes | ) |
T4555 | 2282-2283 | . | denotes | . |
T4556 | 2284-2293 | JJ | denotes | Anti-CD40 |
T4557 | 2294-2302 | NN | denotes | antibody |
T4558 | 2303-2314 | NN | denotes | stimulation |
T4559 | 2315-2320 | RB | denotes | alone |
T4560 | 2321-2323 | CC | denotes | or |
T4561 | 2324-2332 | RB | denotes | together |
T4562 | 2333-2337 | IN | denotes | with |
T4563 | 2338-2342 | NN | denotes | IL-4 |
T4564 | 2343-2350 | VBD | denotes | induced |
T4565 | 2351-2354 | NNP | denotes | GLε |
T4566 | 2355-2368 | NN | denotes | transcription |
T4567 | 2369-2371 | IN | denotes | in |
T4568 | 2372-2380 | JJ | denotes | parental |
T4569 | 2381-2384 | NNP | denotes | A20 |
T4570 | 2384-2386 | CD | denotes | .2 |
T4571 | 2386-2387 | NNP | denotes | J |
T4572 | 2388-2393 | NNS | denotes | cells |
T4573 | 2394-2396 | IN | denotes | as |
T4574 | 2397-2405 | VBN | denotes | expected |
T4575 | 2405-2406 | . | denotes | . |
T4576 | 2407-2409 | IN | denotes | In |
T4577 | 2410-2418 | NN | denotes | contrast |
T4578 | 2418-2419 | , | denotes | , |
T4579 | 2420-2424 | RB | denotes | only |
T4580 | 2425-2428 | JJ | denotes | low |
T4581 | 2429-2435 | NNS | denotes | levels |
T4582 | 2436-2438 | IN | denotes | of |
T4583 | 2439-2442 | NNP | denotes | GLε |
T4584 | 2443-2453 | NN | denotes | expression |
T4585 | 2454-2458 | VBD | denotes | were |
T4586 | 2459-2467 | VBN | denotes | detected |
T4587 | 2468-2470 | IN | denotes | in |
T4588 | 2471-2485 | JJ | denotes | HOIP-deficient |
T4589 | 2486-2491 | NNS | denotes | cells |
T4590 | 2492-2502 | VBN | denotes | stimulated |
T4591 | 2503-2507 | IN | denotes | with |
T4592 | 2508-2514 | DT | denotes | either |
T4593 | 2515-2524 | JJ | denotes | anti-CD40 |
T4594 | 2525-2533 | NN | denotes | antibody |
T4595 | 2534-2539 | RB | denotes | alone |
T4596 | 2540-2542 | CC | denotes | or |
T4597 | 2543-2552 | JJ | denotes | anti-CD40 |
T4598 | 2553-2556 | CC | denotes | and |
T4599 | 2557-2561 | NN | denotes | IL-4 |
T4600 | 2561-2562 | . | denotes | . |
T4601 | 2563-2569 | JJ | denotes | Normal |
T4602 | 2570-2576 | NNS | denotes | levels |
T4603 | 2577-2579 | IN | denotes | of |
T4604 | 2580-2583 | NNP | denotes | GLε |
T4605 | 2584-2594 | NN | denotes | expression |
T4606 | 2595-2599 | VBD | denotes | were |
T4607 | 2600-2607 | VBN | denotes | induced |
T4608 | 2608-2610 | IN | denotes | in |
T4609 | 2611-2629 | JJ | denotes | HOIP-reconstituted |
T4610 | 2630-2635 | NNS | denotes | cells |
T4611 | 2636-2646 | VBN | denotes | stimulated |
T4612 | 2647-2651 | IN | denotes | with |
T4613 | 2652-2661 | JJ | denotes | anti-CD40 |
T4614 | 2662-2670 | NN | denotes | antibody |
T4615 | 2671-2676 | RB | denotes | alone |
T4616 | 2677-2679 | CC | denotes | or |
T4617 | 2680-2688 | RB | denotes | together |
T4618 | 2689-2693 | IN | denotes | with |
T4619 | 2694-2698 | NN | denotes | IL-4 |
T4620 | 2698-2699 | . | denotes | . |
T4621 | 2700-2712 | RB | denotes | Collectively |
T4622 | 2712-2713 | , | denotes | , |
T4623 | 2714-2719 | DT | denotes | these |
T4624 | 2720-2724 | NNS | denotes | data |
T4625 | 2725-2736 | VBP | denotes | demonstrate |
T4626 | 2737-2741 | IN | denotes | that |
T4627 | 2742-2746 | NNP | denotes | HOIP |
T4628 | 2747-2750 | VBZ | denotes | has |
T4629 | 2751-2752 | DT | denotes | a |
T4630 | 2753-2761 | JJ | denotes | critical |
T4631 | 2762-2766 | NN | denotes | role |
T4632 | 2767-2769 | IN | denotes | in |
T4633 | 2770-2778 | JJ | denotes | cellular |
T4634 | 2779-2788 | NNS | denotes | responses |
T4635 | 2789-2791 | TO | denotes | to |
T4636 | 2792-2796 | CD | denotes | CD40 |
T4637 | 2797-2806 | VBG | denotes | signaling |
T4638 | 2806-2807 | . | denotes | . |
T15392 | 850-863 | JJ | denotes | CD40-mediated |
T15393 | 864-868 | NN | denotes | CD80 |
T15394 | 869-881 | NN | denotes | upregulation |
T15395 | 882-884 | VBZ | denotes | is |
T15396 | 885-894 | JJ | denotes | defective |
T15397 | 895-897 | IN | denotes | in |
T15398 | 898-912 | JJ | denotes | HOIP-deficient |
T15399 | 913-918 | NNS | denotes | cells |
T15400 | 918-919 | . | denotes | . |
T15401 | 920-925 | NNS | denotes | Cells |
T15402 | 926-930 | VBD | denotes | were |
T15403 | 931-940 | VBN | denotes | incubated |
T15404 | 941-944 | IN | denotes | for |
T15405 | 945-947 | CD | denotes | 72 |
T15406 | 948-951 | NNS | denotes | hrs |
T15407 | 952-956 | IN | denotes | with |
T15408 | 957-959 | DT | denotes | an |
T15409 | 960-967 | NN | denotes | isotype |
T15410 | 968-975 | NN | denotes | control |
T15411 | 976-984 | NN | denotes | antibody |
T15412 | 985-986 | -LRB- | denotes | ( |
T15413 | 986-990 | VBN | denotes | left |
T15414 | 990-991 | -RRB- | denotes | ) |
T15415 | 992-994 | CC | denotes | or |
T15416 | 995-1004 | JJ | denotes | anti-CD40 |
T15417 | 1005-1013 | NN | denotes | antibody |
T15418 | 1014-1015 | -LRB- | denotes | ( |
T15419 | 1015-1020 | NN | denotes | right |
T15420 | 1020-1021 | -RRB- | denotes | ) |
T15421 | 1022-1025 | CC | denotes | and |
T15422 | 1026-1030 | RB | denotes | then |
T15423 | 1031-1038 | VBD | denotes | stained |
T15424 | 1039-1042 | IN | denotes | for |
T15425 | 1043-1053 | NN | denotes | expression |
T15426 | 1054-1056 | IN | denotes | of |
T15427 | 1057-1061 | NNP | denotes | CD80 |
T15428 | 1062-1063 | -LRB- | denotes | ( |
T15429 | 1063-1069 | VBN | denotes | filled |
T15430 | 1070-1078 | NNS | denotes | profiles |
T15431 | 1079-1087 | VBP | denotes | indicate |
T15432 | 1088-1096 | VBG | denotes | staining |
T15433 | 1097-1101 | IN | denotes | with |
T15434 | 1102-1111 | JJ | denotes | anti-CD80 |
T15435 | 1112-1120 | NN | denotes | antibody |
T15436 | 1120-1121 | : | denotes | ; |
T15437 | 1122-1126 | JJ | denotes | open |
T15438 | 1127-1135 | NNS | denotes | profiles |
T15439 | 1136-1139 | VBP | denotes | are |
T15440 | 1140-1148 | VBG | denotes | staining |
T15441 | 1149-1153 | IN | denotes | with |
T15442 | 1154-1156 | DT | denotes | an |
T15443 | 1157-1164 | NN | denotes | isotype |
T15444 | 1165-1172 | NN | denotes | control |
T15445 | 1173-1181 | NN | denotes | antibody |
T15446 | 1181-1182 | -RRB- | denotes | ) |
T15447 | 1182-1183 | . | denotes | . |
T15448 | 1184-1196 | NNP | denotes | Transduction |
T15449 | 1197-1199 | IN | denotes | of |
T15450 | 1200-1204 | DT | denotes | both |
T15451 | 1205-1219 | JJ | denotes | HOIP-deficient |
T15452 | 1220-1221 | -LRB- | denotes | ( |
T15453 | 1221-1225 | SYM | denotes | HOIP |
T15454 | 1225-1226 | : | denotes | - |
T15455 | 1226-1227 | SYM | denotes | / |
T15456 | 1227-1228 | : | denotes | - |
T15457 | 1228-1229 | -RRB- | denotes | ) |
T15458 | 1230-1236 | NNS | denotes | clones |
T15459 | 1237-1241 | IN | denotes | with |
T15460 | 1242-1243 | DT | denotes | a |
T15461 | 1244-1254 | NN | denotes | retrovirus |
T15462 | 1255-1263 | VBG | denotes | encoding |
T15463 | 1264-1273 | NNP | denotes | FLAG-HOIP |
T15464 | 1274-1282 | VBD | denotes | reversed |
T15465 | 1283-1292 | JJ | denotes | defective |
T15466 | 1293-1297 | NNP | denotes | CD80 |
T15467 | 1298-1310 | NN | denotes | upregulation |
T15468 | 1310-1311 | , | denotes | , |
T15469 | 1312-1317 | IN | denotes | while |
T15470 | 1318-1330 | NN | denotes | transduction |
T15471 | 1331-1335 | IN | denotes | with |
T15472 | 1336-1338 | DT | denotes | an |
T15473 | 1339-1344 | JJ | denotes | empty |
T15474 | 1345-1351 | NN | denotes | vector |
T15475 | 1352-1353 | -LRB- | denotes | ( |
T15476 | 1353-1357 | NNP | denotes | pMIP |
T15477 | 1357-1358 | -RRB- | denotes | ) |
T15478 | 1359-1362 | VBD | denotes | did |
T15479 | 1363-1366 | RB | denotes | not |
T15480 | 1366-1367 | . | denotes | . |
T15481 | 1368-1375 | JJ | denotes | Similar |
T15482 | 1376-1383 | NNS | denotes | results |
T15483 | 1384-1388 | VBD | denotes | were |
T15484 | 1389-1397 | VBN | denotes | obtained |
T15485 | 1398-1400 | IN | denotes | in |
T15486 | 1401-1402 | DT | denotes | a |
T15487 | 1403-1409 | JJ | denotes | second |
T15488 | 1410-1420 | NN | denotes | experiment |
T15489 | 1420-1421 | . | denotes | . |
T15742 | 2852-2855 | NNP | denotes | GLε |
T15743 | 2856-2869 | NN | denotes | transcription |
T15744 | 2870-2872 | VBZ | denotes | is |
T15745 | 2873-2882 | JJ | denotes | defective |
T15746 | 2883-2885 | IN | denotes | in |
T15747 | 2886-2901 | JJ | denotes | CD40-stimulated |
T15748 | 2902-2916 | JJ | denotes | HOIP-deficient |
T15749 | 2917-2922 | NNS | denotes | cells |
T15750 | 2922-2923 | . | denotes | . |
T15751 | 2924-2927 | CD | denotes | A20 |
T15752 | 2927-2929 | CD | denotes | .2 |
T15753 | 2929-2930 | NNP | denotes | J |
T15754 | 2931-2934 | CC | denotes | and |
T15755 | 2935-2949 | JJ | denotes | HOIP-deficient |
T15756 | 2950-2955 | NNS | denotes | cells |
T15757 | 2956-2966 | VBN | denotes | transduced |
T15758 | 2967-2971 | IN | denotes | with |
T15759 | 2972-2974 | DT | denotes | an |
T15760 | 2975-2980 | JJ | denotes | empty |
T15761 | 2981-2991 | NN | denotes | retroviral |
T15762 | 2992-2998 | NN | denotes | vector |
T15763 | 2999-3000 | -LRB- | denotes | ( |
T15764 | 3000-3003 | CD | denotes | A20 |
T15765 | 3003-3005 | CD | denotes | .2 |
T15766 | 3005-3006 | NNP | denotes | J |
T15767 | 3007-3008 | CD | denotes | + |
T15768 | 3009-3013 | NNP | denotes | pMIP |
T15769 | 3014-3017 | CC | denotes | and |
T15770 | 3018-3022 | NNP | denotes | HOIP |
T15771 | 3022-3023 | : | denotes | - |
T15772 | 3023-3024 | SYM | denotes | / |
T15773 | 3024-3025 | : | denotes | - |
T15774 | 3026-3027 | NN | denotes | + |
T15775 | 3028-3032 | NNP | denotes | pMIP |
T15776 | 3032-3033 | , | denotes | , |
T15777 | 3034-3046 | RB | denotes | respectively |
T15778 | 3046-3047 | -RRB- | denotes | ) |
T15779 | 3047-3048 | , | denotes | , |
T15780 | 3049-3051 | CC | denotes | or |
T15781 | 3052-3066 | JJ | denotes | HOIP-deficient |
T15782 | 3067-3072 | NNS | denotes | cells |
T15783 | 3073-3083 | VBN | denotes | transduced |
T15784 | 3084-3088 | IN | denotes | with |
T15785 | 3089-3090 | DT | denotes | a |
T15786 | 3091-3104 | JJ | denotes | HOIP-encoding |
T15787 | 3105-3115 | NN | denotes | retrovirus |
T15788 | 3116-3117 | -LRB- | denotes | ( |
T15789 | 3117-3121 | SYM | denotes | HOIP |
T15790 | 3121-3122 | : | denotes | - |
T15791 | 3122-3123 | SYM | denotes | / |
T15792 | 3123-3124 | : | denotes | - |
T15793 | 3125-3126 | NN | denotes | + |
T15794 | 3127-3131 | NNP | denotes | HOIP |
T15795 | 3131-3132 | -RRB- | denotes | ) |
T15796 | 3133-3137 | VBD | denotes | were |
T15797 | 3138-3146 | VBN | denotes | cultured |
T15798 | 3147-3156 | JJ | denotes | overnight |
T15799 | 3157-3161 | IN | denotes | with |
T15800 | 3162-3171 | JJ | denotes | agonistic |
T15801 | 3172-3181 | JJ | denotes | anti-CD40 |
T15802 | 3182-3184 | CC | denotes | or |
T15803 | 3185-3187 | DT | denotes | an |
T15804 | 3188-3195 | NN | denotes | isotype |
T15805 | 3196-3203 | NN | denotes | control |
T15806 | 3204-3212 | NN | denotes | antibody |
T15807 | 3213-3214 | -LRB- | denotes | ( |
T15808 | 3214-3217 | FW | denotes | iso |
T15809 | 3217-3218 | -RRB- | denotes | ) |
T15810 | 3218-3219 | , | denotes | , |
T15811 | 3220-3224 | IN | denotes | with |
T15812 | 3225-3227 | CC | denotes | or |
T15813 | 3228-3235 | IN | denotes | without |
T15814 | 3236-3240 | NN | denotes | IL-4 |
T15815 | 3240-3241 | . | denotes | . |
T15816 | 3242-3245 | NNP | denotes | RNA |
T15817 | 3246-3249 | VBD | denotes | was |
T15818 | 3250-3258 | VBN | denotes | isolated |
T15819 | 3259-3263 | IN | denotes | from |
T15820 | 3264-3267 | DT | denotes | the |
T15821 | 3268-3273 | NNS | denotes | cells |
T15822 | 3273-3274 | , | denotes | , |
T15823 | 3275-3294 | JJ | denotes | reverse-transcribed |
T15824 | 3294-3295 | , | denotes | , |
T15825 | 3296-3299 | CC | denotes | and |
T15826 | 3300-3304 | RB | denotes | then |
T15827 | 3305-3314 | VBN | denotes | subjected |
T15828 | 3315-3317 | TO | denotes | to |
T15829 | 3318-3330 | JJ | denotes | quantitative |
T15830 | 3331-3334 | NNP | denotes | PCR |
T15831 | 3335-3337 | TO | denotes | to |
T15832 | 3338-3347 | VB | denotes | determine |
T15833 | 3348-3354 | NNS | denotes | levels |
T15834 | 3355-3357 | IN | denotes | of |
T15835 | 3358-3361 | NNP | denotes | GLε |
T15836 | 3362-3373 | NNS | denotes | transcripts |
T15837 | 3373-3374 | . | denotes | . |
T15838 | 3375-3382 | NNS | denotes | Results |
T15839 | 3383-3387 | VBD | denotes | were |
T15840 | 3388-3398 | VBN | denotes | normalized |
T15841 | 3399-3401 | TO | denotes | to |
T15842 | 3402-3405 | DT | denotes | the |
T15843 | 3406-3412 | NNS | denotes | levels |
T15844 | 3413-3415 | IN | denotes | of |
T15845 | 3416-3421 | JJ | denotes | Hprt1 |
T15846 | 3422-3433 | NNS | denotes | transcripts |
T15847 | 3434-3436 | IN | denotes | in |
T15848 | 3437-3441 | DT | denotes | each |
T15849 | 3442-3448 | NN | denotes | sample |
T15850 | 3448-3449 | . | denotes | . |
T15851 | 3450-3457 | NNS | denotes | Symbols |
T15852 | 3458-3466 | VBP | denotes | indicate |
T15853 | 3467-3470 | DT | denotes | the |
T15854 | 3471-3477 | NNS | denotes | values |
T15855 | 3478-3482 | IN | denotes | from |
T15856 | 3483-3492 | VBP | denotes | duplicate |
T15857 | 3493-3501 | NNS | denotes | cultures |
T15858 | 3502-3503 | -LRB- | denotes | ( |
T15859 | 3503-3504 | DT | denotes | a |
T15860 | 3505-3509 | NN | denotes | line |
T15861 | 3510-3519 | VBZ | denotes | indicates |
T15862 | 3520-3523 | DT | denotes | the |
T15863 | 3524-3528 | NN | denotes | mean |
T15864 | 3529-3531 | IN | denotes | of |
T15865 | 3532-3535 | DT | denotes | the |
T15866 | 3536-3539 | CD | denotes | two |
T15867 | 3540-3546 | NNS | denotes | values |
T15868 | 3546-3547 | -RRB- | denotes | ) |
T15869 | 3547-3548 | . | denotes | . |
T15870 | 3549-3556 | JJ | denotes | Similar |
T15871 | 3557-3564 | NNS | denotes | results |
T15872 | 3565-3569 | VBD | denotes | were |
T15873 | 3570-3578 | VBN | denotes | obtained |
T15874 | 3579-3581 | IN | denotes | in |
T15875 | 3582-3583 | DT | denotes | a |
T15876 | 3584-3590 | JJ | denotes | second |
T15877 | 3591-3601 | NN | denotes | experiment |
T15878 | 3602-3605 | CC | denotes | and |
T15879 | 3606-3608 | IN | denotes | in |
T15880 | 3609-3611 | DT | denotes | an |
T15881 | 3612-3622 | JJ | denotes | additional |
T15882 | 3623-3633 | NN | denotes | experiment |
T15883 | 3634-3638 | IN | denotes | with |
T15884 | 3639-3640 | DT | denotes | a |
T15885 | 3641-3647 | JJ | denotes | second |
T15886 | 3648-3662 | JJ | denotes | HOIP-deficient |
T15887 | 3663-3668 | NN | denotes | clone |
T15888 | 3668-3669 | . | denotes | . |
R3249 | T4259 | T4261 | nsubjpass | HOIP,required |
R3250 | T4260 | T4261 | auxpass | is,required |
R3251 | T4261 | T4261 | ROOT | required,required |
R3252 | T4262 | T4261 | prep | for,required |
R3253 | T4263 | T4265 | amod | CD40-mediated,upregulation |
R3254 | T4264 | T4265 | compound | CD80,upregulation |
R3255 | T4265 | T4262 | pobj | upregulation,for |
R3256 | T4266 | T4265 | cc | and,upregulation |
R3257 | T4267 | T4265 | conj | activation,upregulation |
R3258 | T4268 | T4267 | prep | of,activation |
R3259 | T4269 | T4271 | compound | germline,transcription |
R3260 | T4270 | T4271 | compound | epsilon,transcription |
R3261 | T4271 | T4268 | pobj | transcription,of |
R3262 | T4272 | T4265 | conj | Engagement,upregulation |
R3263 | T4273 | T4272 | prep | of,Engagement |
R3264 | T4274 | T4273 | pobj | CD40,of |
R3265 | T4275 | T4272 | prep | on,Engagement |
R3266 | T4276 | T4277 | compound | B,cells |
R3267 | T4277 | T4275 | pobj | cells,on |
R3268 | T4278 | T4279 | compound | upregulates,expression |
R3269 | T4279 | T4261 | dobj | expression,required |
R3270 | T4280 | T4279 | prep | of,expression |
R3271 | T4281 | T4282 | compound | CD80,[ |
R3272 | T4282 | T4280 | pobj | [,of |
R3273 | T4283 | T4284 | nummod | 10,] |
R3274 | T4284 | T4279 | appos | ],expression |
R3275 | T4285 | T4284 | punct | ",",] |
R3276 | T4286 | T4289 | det | a,protein |
R3277 | T4287 | T4288 | compound | cell,surface |
R3278 | T4288 | T4289 | compound | surface,protein |
R3279 | T4289 | T4279 | appos | protein,expression |
R3280 | T4290 | T4291 | nsubj | that,promotes |
R3281 | T4291 | T4289 | relcl | promotes,protein |
R3282 | T4292 | T4291 | dobj | activation,promotes |
R3283 | T4293 | T4292 | prep | of,activation |
R3284 | T4294 | T4295 | compound | T,cells |
R3285 | T4295 | T4293 | pobj | cells,of |
R3286 | T4296 | T4295 | acl | interacting,cells |
R3287 | T4297 | T4296 | prep | with,interacting |
R3288 | T4298 | T4299 | compound | B,cells |
R3289 | T4299 | T4297 | pobj | cells,with |
R3290 | T4300 | T4299 | cc | and,cells |
R3291 | T4301 | T4302 | amod | other,APC |
R3292 | T4302 | T4299 | conj | APC,cells |
R3293 | T4303 | T4261 | punct | .,required |
R3294 | T4304 | T4305 | aux | To,begin |
R3295 | T4305 | T4316 | advcl | begin,assayed |
R3296 | T4306 | T4305 | xcomp | evaluating,begin |
R3297 | T4307 | T4308 | amod | potential,contributions |
R3298 | T4308 | T4306 | dobj | contributions,evaluating |
R3299 | T4309 | T4308 | prep | of,contributions |
R3300 | T4310 | T4309 | pobj | HOIP,of |
R3301 | T4311 | T4306 | prep | to,evaluating |
R3302 | T4312 | T4313 | nsubj | CD40,signaling |
R3303 | T4313 | T4311 | pcomp | signaling,to |
R3304 | T4314 | T4316 | punct | ",",assayed |
R3305 | T4315 | T4316 | nsubj | we,assayed |
R3306 | T4316 | T4316 | ROOT | assayed,assayed |
R3307 | T4317 | T4318 | det | the,upregulation |
R3308 | T4318 | T4316 | dobj | upregulation,assayed |
R3309 | T4319 | T4318 | prep | of,upregulation |
R3310 | T4320 | T4319 | pobj | CD80,of |
R3311 | T4321 | T4318 | acl | induced,upregulation |
R3312 | T4322 | T4321 | agent | by,induced |
R3313 | T4323 | T4322 | pobj | engagement,by |
R3314 | T4324 | T4323 | prep | of,engagement |
R3315 | T4325 | T4324 | pobj | CD40,of |
R3316 | T4326 | T4323 | prep | on,engagement |
R3317 | T4327 | T4330 | amod | parental,J |
R3318 | T4328 | T4330 | nmod | A20,J |
R3319 | T4329 | T4330 | nummod | .2,J |
R3320 | T4330 | T4326 | pobj | J,on |
R3321 | T4331 | T4330 | punct | ",",J |
R3322 | T4332 | T4330 | conj | HOIP-deficient,J |
R3323 | T4333 | T4332 | punct | ",",HOIP-deficient |
R3324 | T4334 | T4332 | cc | and,HOIP-deficient |
R3325 | T4335 | T4336 | amod | HOIP-reconstituted,cells |
R3326 | T4336 | T4332 | conj | cells,HOIP-deficient |
R3327 | T4337 | T4338 | punct | (,Fig. |
R3328 | T4338 | T4336 | parataxis | Fig.,cells |
R3329 | T4339 | T4338 | nummod | 2,Fig. |
R3330 | T4340 | T4338 | punct | ),Fig. |
R3331 | T4341 | T4316 | punct | .,assayed |
R3332 | T4342 | T4356 | prep | Compared,reduced |
R3333 | T4343 | T4342 | prep | to,Compared |
R3334 | T4344 | T4347 | det | the,line |
R3335 | T4345 | T4347 | amod | parental,line |
R3336 | T4346 | T4347 | compound | cell,line |
R3337 | T4347 | T4343 | pobj | line,to |
R3338 | T4348 | T4347 | punct | ",",line |
R3339 | T4349 | T4351 | det | the,upregulation |
R3340 | T4350 | T4351 | amod | CD40-stimulated,upregulation |
R3341 | T4351 | T4356 | nsubjpass | upregulation,reduced |
R3342 | T4352 | T4351 | prep | of,upregulation |
R3343 | T4353 | T4352 | pobj | CD80,of |
R3344 | T4354 | T4356 | auxpass | was,reduced |
R3345 | T4355 | T4356 | advmod | dramatically,reduced |
R3346 | T4356 | T4356 | ROOT | reduced,reduced |
R3347 | T4357 | T4356 | prep | in,reduced |
R3348 | T4358 | T4360 | det | all,cells |
R3349 | T4359 | T4360 | amod | HOIP-deficient,cells |
R3350 | T4360 | T4357 | pobj | cells,in |
R3351 | T4361 | T4356 | conj | tested,reduced |
R3352 | T4362 | T4356 | punct | .,reduced |
R3353 | T4363 | T4370 | prep | In,restored |
R3354 | T4364 | T4363 | pobj | contrast,In |
R3355 | T4365 | T4370 | punct | ",",restored |
R3356 | T4366 | T4370 | nsubjpass | upregulation,restored |
R3357 | T4367 | T4366 | prep | of,upregulation |
R3358 | T4368 | T4367 | pobj | CD80,of |
R3359 | T4369 | T4370 | auxpass | was,restored |
R3360 | T4370 | T4370 | ROOT | restored,restored |
R3361 | T4371 | T4370 | prep | in,restored |
R3362 | T4372 | T4373 | amod | HOIP-reconstituted,cells |
R3363 | T4373 | T4371 | pobj | cells,in |
R3364 | T4374 | T4370 | punct | ",",restored |
R3365 | T4375 | T4370 | advcl | confirming,restored |
R3366 | T4376 | T4386 | mark | that,was |
R3367 | T4377 | T4378 | det | the,defect |
R3368 | T4378 | T4386 | nsubj | defect,was |
R3369 | T4379 | T4378 | prep | in,defect |
R3370 | T4380 | T4381 | compound | CD80,upregulation |
R3371 | T4381 | T4379 | pobj | upregulation,in |
R3372 | T4382 | T4381 | prep | in,upregulation |
R3373 | T4383 | T4385 | det | the,cells |
R3374 | T4384 | T4385 | amod | HOIP-deficient,cells |
R3375 | T4385 | T4382 | pobj | cells,in |
R3376 | T4386 | T4375 | ccomp | was,confirming |
R3377 | T4387 | T4386 | acomp | due,was |
R3378 | T4388 | T4387 | prep | to,due |
R3379 | T4389 | T4390 | det | the,disruption |
R3380 | T4390 | T4388 | pobj | disruption,to |
R3381 | T4391 | T4390 | prep | of,disruption |
R3382 | T4392 | T4391 | pobj | Rnf31,of |
R3383 | T4393 | T4370 | punct | .,restored |
R3384 | T4394 | T4395 | nummod | CD40,signals |
R3385 | T4395 | T4401 | nsubj | signals,contribute |
R3386 | T4396 | T4395 | prep | in,signals |
R3387 | T4397 | T4398 | compound | B,cells |
R3388 | T4398 | T4396 | pobj | cells,in |
R3389 | T4399 | T4401 | aux | can,contribute |
R3390 | T4400 | T4401 | advmod | also,contribute |
R3391 | T4401 | T4401 | ROOT | contribute,contribute |
R3392 | T4402 | T4401 | prep | to,contribute |
R3393 | T4403 | T4404 | det | the,activation |
R3394 | T4404 | T4402 | pobj | activation,to |
R3395 | T4405 | T4404 | prep | of,activation |
R3396 | T4406 | T4407 | compound | DNA,recombination |
R3397 | T4407 | T4405 | pobj | recombination,of |
R3398 | T4408 | T4404 | prep | in,activation |
R3399 | T4409 | T4413 | det | the,locus |
R3400 | T4410 | T4413 | compound | immunoglobulin,locus |
R3401 | T4411 | T4412 | amod | heavy,chain |
R3402 | T4412 | T4413 | compound | chain,locus |
R3403 | T4413 | T4408 | pobj | locus,in |
R3404 | T4414 | T4416 | compound | [,] |
R3405 | T4415 | T4416 | compound | 11,] |
R3406 | T4416 | T4404 | appos | ],activation |
R3407 | T4417 | T4416 | punct | ",",] |
R3408 | T4418 | T4420 | nmod | [,] |
R3409 | T4419 | T4420 | nummod | 12,] |
R3410 | T4420 | T4416 | appos | ],] |
R3411 | T4421 | T4401 | punct | .,contribute |
R3412 | T4422 | T4423 | det | This,process |
R3413 | T4423 | T4436 | nsubj | process,allows |
R3414 | T4424 | T4423 | punct | ",",process |
R3415 | T4425 | T4423 | acl | known,process |
R3416 | T4426 | T4425 | prep | as,known |
R3417 | T4427 | T4429 | amod | immunoglobulin,switching |
R3418 | T4428 | T4429 | compound | class,switching |
R3419 | T4429 | T4426 | pobj | switching,as |
R3420 | T4430 | T4429 | punct | (,switching |
R3421 | T4431 | T4429 | cc | or,switching |
R3422 | T4432 | T4433 | compound | isotype,switching |
R3423 | T4433 | T4429 | conj | switching,switching |
R3424 | T4434 | T4423 | punct | ),process |
R3425 | T4435 | T4436 | punct | ",",allows |
R3426 | T4436 | T4436 | ROOT | allows,allows |
R3427 | T4437 | T4438 | compound | B,cells |
R3428 | T4438 | T4436 | dobj | cells,allows |
R3429 | T4439 | T4436 | punct | ",",allows |
R3430 | T4440 | T4441 | advmod | initially,expressing |
R3431 | T4441 | T4436 | advcl | expressing,allows |
R3432 | T4442 | T4441 | dobj | IgM,expressing |
R3433 | T4443 | T4436 | punct | ",",allows |
R3434 | T4444 | T4445 | aux | to,switch |
R3435 | T4445 | T4436 | advcl | switch,allows |
R3436 | T4446 | T4445 | prep | to,switch |
R3437 | T4447 | T4446 | pobj | IgA,to |
R3438 | T4448 | T4447 | punct | ",",IgA |
R3439 | T4449 | T4447 | conj | IgG,IgA |
R3440 | T4450 | T4449 | punct | ",",IgG |
R3441 | T4451 | T4449 | cc | or,IgG |
R3442 | T4452 | T4449 | conj | IgE,IgG |
R3443 | T4453 | T4445 | prep | depending,switch |
R3444 | T4454 | T4453 | prep | on,depending |
R3445 | T4455 | T4456 | det | the,class |
R3446 | T4456 | T4454 | pobj | class,on |
R3447 | T4457 | T4456 | prep | of,class |
R3448 | T4458 | T4457 | pobj | antibody,of |
R3449 | T4459 | T4460 | advmod | most,appropriate |
R3450 | T4460 | T4456 | amod | appropriate,class |
R3451 | T4461 | T4460 | prep | for,appropriate |
R3452 | T4462 | T4465 | det | a,response |
R3453 | T4463 | T4465 | amod | particular,response |
R3454 | T4464 | T4465 | amod | immune,response |
R3455 | T4465 | T4461 | pobj | response,for |
R3456 | T4466 | T4436 | punct | .,allows |
R3457 | T4467 | T4472 | nsubjpass | Switching,induced |
R3458 | T4468 | T4467 | prep | to,Switching |
R3459 | T4469 | T4468 | pobj | IgE,to |
R3460 | T4470 | T4472 | aux | can,induced |
R3461 | T4471 | T4472 | auxpass | be,induced |
R3462 | T4472 | T4472 | ROOT | induced,induced |
R3463 | T4473 | T4472 | agent | by,induced |
R3464 | T4474 | T4475 | det | the,combination |
R3465 | T4475 | T4473 | pobj | combination,by |
R3466 | T4476 | T4475 | prep | of,combination |
R3467 | T4477 | T4480 | nmod | IL-4,signals |
R3468 | T4478 | T4477 | cc | and,IL-4 |
R3469 | T4479 | T4480 | amod | CD40,signals |
R3470 | T4480 | T4476 | pobj | signals,of |
R3471 | T4481 | T4472 | punct | .,induced |
R3472 | T4482 | T4484 | det | The,rearrangement |
R3473 | T4483 | T4484 | compound | gene,rearrangement |
R3474 | T4484 | T4490 | nsubjpass | rearrangement,preceded |
R3475 | T4485 | T4484 | amod | necessary,rearrangement |
R3476 | T4486 | T4485 | prep | for,necessary |
R3477 | T4487 | T4488 | amod | IgE,production |
R3478 | T4488 | T4486 | pobj | production,for |
R3479 | T4489 | T4490 | auxpass | is,preceded |
R3480 | T4490 | T4490 | ROOT | preceded,preceded |
R3481 | T4491 | T4490 | agent | by,preceded |
R3482 | T4492 | T4493 | det | the,production |
R3483 | T4493 | T4491 | pobj | production,by |
R3484 | T4494 | T4493 | prep | of,production |
R3485 | T4495 | T4497 | amod | non-coding,transcripts |
R3486 | T4496 | T4497 | compound | RNA,transcripts |
R3487 | T4497 | T4494 | pobj | transcripts,of |
R3488 | T4498 | T4497 | prep | from,transcripts |
R3489 | T4499 | T4500 | amod | germline,sequences |
R3490 | T4500 | T4498 | pobj | sequences,from |
R3491 | T4501 | T4500 | prep | in,sequences |
R3492 | T4502 | T4505 | det | the,chain |
R3493 | T4503 | T4505 | nmod | IgE,chain |
R3494 | T4504 | T4505 | amod | heavy,chain |
R3495 | T4505 | T4501 | pobj | chain,in |
R3496 | T4506 | T4491 | pobj | locus,by |
R3497 | T4507 | T4509 | nmod | [,] |
R3498 | T4508 | T4509 | nummod | 13,] |
R3499 | T4509 | T4506 | appos | ],locus |
R3500 | T4510 | T4490 | punct | .,preceded |
R3501 | T4511 | T4512 | aux | To,determine |
R3502 | T4512 | T4532 | advcl | determine,stimulated |
R3503 | T4513 | T4516 | mark | whether,required |
R3504 | T4514 | T4516 | nsubjpass | HOIP,required |
R3505 | T4515 | T4516 | auxpass | is,required |
R3506 | T4516 | T4512 | ccomp | required,determine |
R3507 | T4517 | T4516 | prep | in,required |
R3508 | T4518 | T4519 | det | the,initiation |
R3509 | T4519 | T4517 | pobj | initiation,in |
R3510 | T4520 | T4519 | prep | of,initiation |
R3511 | T4521 | T4524 | det | the,process |
R3512 | T4522 | T4524 | compound | class,process |
R3513 | T4523 | T4524 | compound | switching,process |
R3514 | T4524 | T4520 | pobj | process,of |
R3515 | T4525 | T4532 | punct | ",",stimulated |
R3516 | T4526 | T4530 | det | the,lines |
R3517 | T4527 | T4530 | amod | relevant,lines |
R3518 | T4528 | T4529 | compound | B,cell |
R3519 | T4529 | T4530 | compound | cell,lines |
R3520 | T4530 | T4532 | nsubjpass | lines,stimulated |
R3521 | T4531 | T4532 | auxpass | were,stimulated |
R3522 | T4532 | T4532 | ROOT | stimulated,stimulated |
R3523 | T4533 | T4532 | prep | through,stimulated |
R3524 | T4534 | T4533 | pobj | CD40,through |
R3525 | T4535 | T4532 | prep | in,stimulated |
R3526 | T4536 | T4537 | det | the,presence |
R3527 | T4537 | T4535 | pobj | presence,in |
R3528 | T4538 | T4537 | prep | of,presence |
R3529 | T4539 | T4538 | pobj | IL-4,of |
R3530 | T4540 | T4532 | cc | and,stimulated |
R3531 | T4541 | T4532 | conj | tested,stimulated |
R3532 | T4542 | T4541 | prep | for,tested |
R3533 | T4543 | T4542 | pobj | production,for |
R3534 | T4544 | T4543 | prep | of,production |
R3535 | T4545 | T4546 | compound | germline,epsilon |
R3536 | T4546 | T4544 | pobj | epsilon,of |
R3537 | T4547 | T4548 | punct | (,GLε |
R3538 | T4548 | T4546 | appos | GLε,epsilon |
R3539 | T4549 | T4546 | punct | ),epsilon |
R3540 | T4550 | T4542 | pobj | transcripts,for |
R3541 | T4551 | T4552 | punct | (,Fig. |
R3542 | T4552 | T4550 | appos | Fig.,transcripts |
R3543 | T4553 | T4552 | nummod | 3,Fig. |
R3544 | T4554 | T4552 | punct | ),Fig. |
R3545 | T4555 | T4532 | punct | .,stimulated |
R3546 | T4556 | T4558 | amod | Anti-CD40,stimulation |
R3547 | T4557 | T4558 | compound | antibody,stimulation |
R3548 | T4558 | T4564 | nsubj | stimulation,induced |
R3549 | T4559 | T4558 | advmod | alone,stimulation |
R3550 | T4560 | T4559 | cc | or,alone |
R3551 | T4561 | T4559 | conj | together,alone |
R3552 | T4562 | T4558 | prep | with,stimulation |
R3553 | T4563 | T4562 | pobj | IL-4,with |
R3554 | T4564 | T4564 | ROOT | induced,induced |
R3555 | T4565 | T4566 | compound | GLε,transcription |
R3556 | T4566 | T4564 | dobj | transcription,induced |
R3557 | T4567 | T4566 | prep | in,transcription |
R3558 | T4568 | T4572 | amod | parental,cells |
R3559 | T4569 | T4572 | compound | A20,cells |
R3560 | T4570 | T4571 | compound | .2,J |
R3561 | T4571 | T4572 | compound | J,cells |
R3562 | T4572 | T4567 | pobj | cells,in |
R3563 | T4573 | T4574 | mark | as,expected |
R3564 | T4574 | T4572 | advcl | expected,cells |
R3565 | T4575 | T4564 | punct | .,induced |
R3566 | T4576 | T4586 | prep | In,detected |
R3567 | T4577 | T4576 | pobj | contrast,In |
R3568 | T4578 | T4586 | punct | ",",detected |
R3569 | T4579 | T4581 | advmod | only,levels |
R3570 | T4580 | T4581 | amod | low,levels |
R3571 | T4581 | T4586 | nsubjpass | levels,detected |
R3572 | T4582 | T4581 | prep | of,levels |
R3573 | T4583 | T4584 | compound | GLε,expression |
R3574 | T4584 | T4582 | pobj | expression,of |
R3575 | T4585 | T4586 | auxpass | were,detected |
R3576 | T4586 | T4586 | ROOT | detected,detected |
R3577 | T4587 | T4586 | prep | in,detected |
R3578 | T4588 | T4589 | amod | HOIP-deficient,cells |
R3579 | T4589 | T4587 | pobj | cells,in |
R3580 | T4590 | T4586 | conj | stimulated,detected |
R3581 | T4591 | T4590 | prep | with,stimulated |
R3582 | T4592 | T4594 | det | either,antibody |
R3583 | T4593 | T4594 | amod | anti-CD40,antibody |
R3584 | T4594 | T4591 | pobj | antibody,with |
R3585 | T4595 | T4594 | advmod | alone,antibody |
R3586 | T4596 | T4594 | cc | or,antibody |
R3587 | T4597 | T4594 | conj | anti-CD40,antibody |
R3588 | T4598 | T4597 | cc | and,anti-CD40 |
R3589 | T4599 | T4597 | conj | IL-4,anti-CD40 |
R3590 | T4600 | T4586 | punct | .,detected |
R3591 | T4601 | T4602 | amod | Normal,levels |
R3592 | T4602 | T4607 | nsubjpass | levels,induced |
R3593 | T4603 | T4602 | prep | of,levels |
R3594 | T4604 | T4605 | compound | GLε,expression |
R3595 | T4605 | T4603 | pobj | expression,of |
R3596 | T4606 | T4607 | auxpass | were,induced |
R3597 | T4607 | T4607 | ROOT | induced,induced |
R3598 | T4608 | T4607 | prep | in,induced |
R3599 | T4609 | T4610 | amod | HOIP-reconstituted,cells |
R3600 | T4610 | T4608 | pobj | cells,in |
R3601 | T4611 | T4607 | conj | stimulated,induced |
R3602 | T4612 | T4611 | prep | with,stimulated |
R3603 | T4613 | T4614 | amod | anti-CD40,antibody |
R3604 | T4614 | T4612 | pobj | antibody,with |
R3605 | T4615 | T4614 | advmod | alone,antibody |
R3606 | T4616 | T4615 | cc | or,alone |
R3607 | T4617 | T4618 | advmod | together,with |
R3608 | T4618 | T4615 | conj | with,alone |
R3609 | T4619 | T4618 | pobj | IL-4,with |
R3610 | T4620 | T4607 | punct | .,induced |
R3611 | T4621 | T4625 | advmod | Collectively,demonstrate |
R3612 | T4622 | T4625 | punct | ",",demonstrate |
R3613 | T4623 | T4624 | det | these,data |
R3614 | T4624 | T4625 | nsubj | data,demonstrate |
R3615 | T4625 | T4625 | ROOT | demonstrate,demonstrate |
R3616 | T4626 | T4628 | mark | that,has |
R3617 | T4627 | T4628 | nsubj | HOIP,has |
R3618 | T4628 | T4625 | ccomp | has,demonstrate |
R3619 | T4629 | T4631 | det | a,role |
R3620 | T4630 | T4631 | amod | critical,role |
R3621 | T4631 | T4628 | dobj | role,has |
R3622 | T4632 | T4631 | prep | in,role |
R3623 | T4633 | T4634 | amod | cellular,responses |
R3624 | T4634 | T4632 | pobj | responses,in |
R3625 | T4635 | T4634 | prep | to,responses |
R3626 | T4636 | T4637 | dep | CD40,signaling |
R3627 | T4637 | T4628 | prep | signaling,has |
R3628 | T4638 | T4625 | punct | .,demonstrate |
R12180 | T15392 | T15394 | amod | CD40-mediated,upregulation |
R12181 | T15393 | T15394 | compound | CD80,upregulation |
R12182 | T15394 | T15395 | nsubj | upregulation,is |
R12183 | T15395 | T15395 | ROOT | is,is |
R12184 | T15396 | T15395 | acomp | defective,is |
R12185 | T15397 | T15396 | prep | in,defective |
R12186 | T15398 | T15399 | amod | HOIP-deficient,cells |
R12187 | T15399 | T15397 | pobj | cells,in |
R12188 | T15400 | T15395 | punct | .,is |
R12189 | T15401 | T15403 | nsubjpass | Cells,incubated |
R12190 | T15402 | T15403 | auxpass | were,incubated |
R12191 | T15403 | T15403 | ROOT | incubated,incubated |
R12192 | T15404 | T15403 | prep | for,incubated |
R12193 | T15405 | T15406 | nummod | 72,hrs |
R12194 | T15406 | T15404 | pobj | hrs,for |
R12195 | T15407 | T15403 | prep | with,incubated |
R12196 | T15408 | T15411 | det | an,antibody |
R12197 | T15409 | T15410 | amod | isotype,control |
R12198 | T15410 | T15411 | compound | control,antibody |
R12199 | T15411 | T15407 | pobj | antibody,with |
R12200 | T15412 | T15413 | punct | (,left |
R12201 | T15413 | T15403 | advcl | left,incubated |
R12202 | T15414 | T15413 | punct | ),left |
R12203 | T15415 | T15413 | cc | or,left |
R12204 | T15416 | T15417 | amod | anti-CD40,antibody |
R12205 | T15417 | T15403 | conj | antibody,incubated |
R12206 | T15418 | T15419 | punct | (,right |
R12207 | T15419 | T15417 | parataxis | right,antibody |
R12208 | T15420 | T15419 | punct | ),right |
R12209 | T15421 | T15403 | cc | and,incubated |
R12210 | T15422 | T15423 | advmod | then,stained |
R12211 | T15423 | T15403 | conj | stained,incubated |
R12212 | T15424 | T15423 | prep | for,stained |
R12213 | T15425 | T15424 | pobj | expression,for |
R12214 | T15426 | T15425 | prep | of,expression |
R12215 | T15427 | T15426 | pobj | CD80,of |
R12216 | T15428 | T15429 | punct | (,filled |
R12217 | T15429 | T15430 | amod | filled,profiles |
R12218 | T15430 | T15431 | nsubj | profiles,indicate |
R12219 | T15431 | T15423 | ccomp | indicate,stained |
R12220 | T15432 | T15431 | ccomp | staining,indicate |
R12221 | T15433 | T15432 | prep | with,staining |
R12222 | T15434 | T15435 | amod | anti-CD80,antibody |
R12223 | T15435 | T15433 | pobj | antibody,with |
R12224 | T15436 | T15431 | punct | ;,indicate |
R12225 | T15437 | T15438 | amod | open,profiles |
R12226 | T15438 | T15440 | nsubj | profiles,staining |
R12227 | T15439 | T15440 | aux | are,staining |
R12228 | T15440 | T15403 | conj | staining,incubated |
R12229 | T15441 | T15440 | prep | with,staining |
R12230 | T15442 | T15445 | det | an,antibody |
R12231 | T15443 | T15444 | amod | isotype,control |
R12232 | T15444 | T15445 | compound | control,antibody |
R12233 | T15445 | T15441 | pobj | antibody,with |
R12234 | T15446 | T15440 | punct | ),staining |
R12235 | T15447 | T15440 | punct | .,staining |
R12236 | T15448 | T15464 | nsubj | Transduction,reversed |
R12237 | T15449 | T15448 | prep | of,Transduction |
R12238 | T15450 | T15451 | det | both,HOIP-deficient |
R12239 | T15451 | T15449 | pobj | HOIP-deficient,of |
R12240 | T15452 | T15451 | punct | (,HOIP-deficient |
R12241 | T15453 | T15455 | amod | HOIP,/ |
R12242 | T15454 | T15455 | punct | -,/ |
R12243 | T15455 | T15455 | ROOT | /,/ |
R12244 | T15456 | T15455 | punct | -,/ |
R12245 | T15457 | T15455 | punct | ),/ |
R12246 | T15458 | T15464 | nsubj | clones,reversed |
R12247 | T15459 | T15458 | prep | with,clones |
R12248 | T15460 | T15461 | det | a,retrovirus |
R12249 | T15461 | T15459 | pobj | retrovirus,with |
R12250 | T15462 | T15461 | acl | encoding,retrovirus |
R12251 | T15463 | T15464 | nsubj | FLAG-HOIP,reversed |
R12252 | T15464 | T15464 | ROOT | reversed,reversed |
R12253 | T15465 | T15467 | amod | defective,upregulation |
R12254 | T15466 | T15467 | compound | CD80,upregulation |
R12255 | T15467 | T15464 | dobj | upregulation,reversed |
R12256 | T15468 | T15464 | punct | ",",reversed |
R12257 | T15469 | T15470 | mark | while,transduction |
R12258 | T15470 | T15464 | advcl | transduction,reversed |
R12259 | T15471 | T15470 | prep | with,transduction |
R12260 | T15472 | T15474 | det | an,vector |
R12261 | T15473 | T15474 | amod | empty,vector |
R12262 | T15474 | T15471 | pobj | vector,with |
R12263 | T15475 | T15474 | punct | (,vector |
R12264 | T15476 | T15474 | appos | pMIP,vector |
R12265 | T15477 | T15474 | punct | ),vector |
R12266 | T15478 | T15480 | aux | did,. |
R12267 | T15479 | T15478 | neg | not,did |
R12268 | T15480 | T15464 | punct | .,reversed |
R12269 | T15481 | T15482 | amod | Similar,results |
R12270 | T15482 | T15484 | nsubjpass | results,obtained |
R12271 | T15483 | T15484 | auxpass | were,obtained |
R12272 | T15484 | T15484 | ROOT | obtained,obtained |
R12273 | T15485 | T15484 | prep | in,obtained |
R12274 | T15486 | T15488 | det | a,experiment |
R12275 | T15487 | T15488 | amod | second,experiment |
R12276 | T15488 | T15485 | pobj | experiment,in |
R12277 | T15489 | T15484 | punct | .,obtained |
R12429 | T15742 | T15743 | compound | GLε,transcription |
R12430 | T15743 | T15744 | nsubj | transcription,is |
R12431 | T15744 | T15744 | ROOT | is,is |
R12432 | T15745 | T15744 | acomp | defective,is |
R12433 | T15746 | T15745 | prep | in,defective |
R12434 | T15747 | T15749 | amod | CD40-stimulated,cells |
R12435 | T15748 | T15749 | amod | HOIP-deficient,cells |
R12436 | T15749 | T15746 | pobj | cells,in |
R12437 | T15750 | T15744 | punct | .,is |
R12438 | T15751 | T15753 | nummod | A20,J |
R12439 | T15752 | T15753 | nummod | .2,J |
R12440 | T15753 | T15756 | nmod | J,cells |
R12441 | T15754 | T15753 | cc | and,J |
R12442 | T15755 | T15753 | conj | HOIP-deficient,J |
R12443 | T15756 | T15756 | ROOT | cells,cells |
R12444 | T15757 | T15756 | acl | transduced,cells |
R12445 | T15758 | T15757 | prep | with,transduced |
R12446 | T15759 | T15762 | det | an,vector |
R12447 | T15760 | T15762 | amod | empty,vector |
R12448 | T15761 | T15762 | compound | retroviral,vector |
R12449 | T15762 | T15758 | pobj | vector,with |
R12450 | T15763 | T15762 | punct | (,vector |
R12451 | T15764 | T15768 | nummod | A20,pMIP |
R12452 | T15765 | T15768 | nummod | .2,pMIP |
R12453 | T15766 | T15768 | nmod | J,pMIP |
R12454 | T15767 | T15768 | nummod | +,pMIP |
R12455 | T15768 | T15762 | appos | pMIP,vector |
R12456 | T15769 | T15768 | cc | and,pMIP |
R12457 | T15770 | T15768 | conj | HOIP,pMIP |
R12458 | T15771 | T15762 | punct | -,vector |
R12459 | T15772 | T15762 | punct | /,vector |
R12460 | T15773 | T15762 | punct | -,vector |
R12461 | T15774 | T15775 | compound | +,pMIP |
R12462 | T15775 | T15762 | appos | pMIP,vector |
R12463 | T15776 | T15775 | punct | ",",pMIP |
R12464 | T15777 | T15775 | advmod | respectively,pMIP |
R12465 | T15778 | T15775 | punct | ),pMIP |
R12466 | T15779 | T15775 | punct | ",",pMIP |
R12467 | T15780 | T15775 | cc | or,pMIP |
R12468 | T15781 | T15782 | amod | HOIP-deficient,cells |
R12469 | T15782 | T15775 | conj | cells,pMIP |
R12470 | T15783 | T15762 | acl | transduced,vector |
R12471 | T15784 | T15783 | prep | with,transduced |
R12472 | T15785 | T15787 | det | a,retrovirus |
R12473 | T15786 | T15787 | amod | HOIP-encoding,retrovirus |
R12474 | T15787 | T15784 | pobj | retrovirus,with |
R12475 | T15788 | T15797 | punct | (,cultured |
R12476 | T15789 | T15793 | punct | HOIP,+ |
R12477 | T15790 | T15793 | punct | -,+ |
R12478 | T15791 | T15793 | punct | /,+ |
R12479 | T15792 | T15793 | punct | -,+ |
R12480 | T15793 | T15797 | nsubjpass | +,cultured |
R12481 | T15794 | T15793 | npadvmod | HOIP,+ |
R12482 | T15795 | T15797 | punct | ),cultured |
R12483 | T15796 | T15797 | auxpass | were,cultured |
R12484 | T15797 | T15787 | parataxis | cultured,retrovirus |
R12485 | T15798 | T15797 | npadvmod | overnight,cultured |
R12486 | T15799 | T15797 | prep | with,cultured |
R12487 | T15800 | T15801 | amod | agonistic,anti-CD40 |
R12488 | T15801 | T15799 | pobj | anti-CD40,with |
R12489 | T15802 | T15801 | cc | or,anti-CD40 |
R12490 | T15803 | T15806 | det | an,antibody |
R12491 | T15804 | T15806 | nmod | isotype,antibody |
R12492 | T15805 | T15806 | compound | control,antibody |
R12493 | T15806 | T15801 | conj | antibody,anti-CD40 |
R12494 | T15807 | T15806 | punct | (,antibody |
R12495 | T15808 | T15806 | parataxis | iso,antibody |
R12496 | T15809 | T15808 | punct | ),iso |
R12497 | T15810 | T15806 | punct | ",",antibody |
R12498 | T15811 | T15806 | conj | with,antibody |
R12499 | T15812 | T15811 | cc | or,with |
R12500 | T15813 | T15811 | conj | without,with |
R12501 | T15814 | T15813 | pobj | IL-4,without |
R12502 | T15815 | T15756 | punct | .,cells |
R12503 | T15816 | T15818 | nsubjpass | RNA,isolated |
R12504 | T15817 | T15818 | auxpass | was,isolated |
R12505 | T15818 | T15818 | ROOT | isolated,isolated |
R12506 | T15819 | T15818 | prep | from,isolated |
R12507 | T15820 | T15821 | det | the,cells |
R12508 | T15821 | T15819 | pobj | cells,from |
R12509 | T15822 | T15818 | punct | ",",isolated |
R12510 | T15823 | T15818 | conj | reverse-transcribed,isolated |
R12511 | T15824 | T15823 | punct | ",",reverse-transcribed |
R12512 | T15825 | T15823 | cc | and,reverse-transcribed |
R12513 | T15826 | T15827 | advmod | then,subjected |
R12514 | T15827 | T15823 | conj | subjected,reverse-transcribed |
R12515 | T15828 | T15827 | prep | to,subjected |
R12516 | T15829 | T15830 | amod | quantitative,PCR |
R12517 | T15830 | T15828 | pobj | PCR,to |
R12518 | T15831 | T15832 | aux | to,determine |
R12519 | T15832 | T15827 | advcl | determine,subjected |
R12520 | T15833 | T15832 | dobj | levels,determine |
R12521 | T15834 | T15833 | prep | of,levels |
R12522 | T15835 | T15836 | compound | GLε,transcripts |
R12523 | T15836 | T15834 | pobj | transcripts,of |
R12524 | T15837 | T15818 | punct | .,isolated |
R12525 | T15838 | T15839 | nsubj | Results,were |
R12526 | T15839 | T15839 | ROOT | were,were |
R12527 | T15840 | T15839 | acomp | normalized,were |
R12528 | T15841 | T15840 | prep | to,normalized |
R12529 | T15842 | T15843 | det | the,levels |
R12530 | T15843 | T15841 | pobj | levels,to |
R12531 | T15844 | T15843 | prep | of,levels |
R12532 | T15845 | T15846 | amod | Hprt1,transcripts |
R12533 | T15846 | T15844 | pobj | transcripts,of |
R12534 | T15847 | T15843 | prep | in,levels |
R12535 | T15848 | T15849 | det | each,sample |
R12536 | T15849 | T15847 | pobj | sample,in |
R12537 | T15850 | T15839 | punct | .,were |
R12538 | T15851 | T15852 | nsubj | Symbols,indicate |
R12539 | T15852 | T15852 | ROOT | indicate,indicate |
R12540 | T15853 | T15854 | det | the,values |
R12541 | T15854 | T15852 | dobj | values,indicate |
R12542 | T15855 | T15852 | prep | from,indicate |
R12543 | T15856 | T15857 | compound | duplicate,cultures |
R12544 | T15857 | T15855 | pobj | cultures,from |
R12545 | T15858 | T15857 | punct | (,cultures |
R12546 | T15859 | T15860 | det | a,line |
R12547 | T15860 | T15861 | nsubj | line,indicates |
R12548 | T15861 | T15852 | ccomp | indicates,indicate |
R12549 | T15862 | T15863 | det | the,mean |
R12550 | T15863 | T15861 | dobj | mean,indicates |
R12551 | T15864 | T15863 | prep | of,mean |
R12552 | T15865 | T15867 | det | the,values |
R12553 | T15866 | T15867 | nummod | two,values |
R12554 | T15867 | T15864 | pobj | values,of |
R12555 | T15868 | T15861 | punct | ),indicates |
R12556 | T15869 | T15852 | punct | .,indicate |
R12557 | T15870 | T15871 | amod | Similar,results |
R12558 | T15871 | T15873 | nsubjpass | results,obtained |
R12559 | T15872 | T15873 | auxpass | were,obtained |
R12560 | T15873 | T15873 | ROOT | obtained,obtained |
R12561 | T15874 | T15873 | prep | in,obtained |
R12562 | T15875 | T15877 | det | a,experiment |
R12563 | T15876 | T15877 | amod | second,experiment |
R12564 | T15877 | T15874 | pobj | experiment,in |
R12565 | T15878 | T15874 | cc | and,in |
R12566 | T15879 | T15874 | conj | in,in |
R12567 | T15880 | T15882 | det | an,experiment |
R12568 | T15881 | T15882 | amod | additional,experiment |
R12569 | T15882 | T15879 | pobj | experiment,in |
R12570 | T15883 | T15882 | prep | with,experiment |
R12571 | T15884 | T15887 | det | a,clone |
R12572 | T15885 | T15887 | amod | second,clone |
R12573 | T15886 | T15887 | amod | HOIP-deficient,clone |
R12574 | T15887 | T15883 | pobj | clone,with |
R12575 | T15888 | T15873 | punct | .,obtained |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T5069 | 88-101 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
T5070 | 2355-2368 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
T5071 | 171-191 | http://purl.obolibrary.org/obo/GO_0033580 | denotes | cell surface protein |
T5072 | 171-191 | http://purl.obolibrary.org/obo/GO_0034394 | denotes | cell surface protein |
T5073 | 171-191 | http://purl.obolibrary.org/obo/GO_0033575 | denotes | cell surface protein |
T5074 | 328-337 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
T5075 | 2797-2806 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
T5076 | 1475-1506 | http://purl.obolibrary.org/obo/GO_0045911 | denotes | activation of DNA recombination |
T5077 | 1489-1506 | http://purl.obolibrary.org/obo/GO_0006310 | denotes | DNA recombination |
T5078 | 1597-1612 | http://purl.obolibrary.org/obo/GO_0045190 | denotes | class switching |
T5079 | 1603-1624 | http://purl.obolibrary.org/obo/GO_0045190 | denotes | switching (or isotype |
T5080 | 1597-1624 | http://purl.obolibrary.org/obo/GO_0048290 | denotes | class switching (or isotype |
T5081 | 1597-1624 | http://purl.obolibrary.org/obo/GO_0048292 | denotes | class switching (or isotype |
T5082 | 1597-1624 | http://purl.obolibrary.org/obo/GO_0048289 | denotes | class switching (or isotype |
T5083 | 1597-1624 | http://purl.obolibrary.org/obo/GO_0048291 | denotes | class switching (or isotype |
T5084 | 1778-1793 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
T5085 | 2770-2778 | http://purl.obolibrary.org/obo/GO_0007349 | denotes | cellular |
T15595 | 1184-1196 | http://purl.obolibrary.org/obo/GO_0009293 | denotes | Transduction |
T15596 | 1318-1330 | http://purl.obolibrary.org/obo/GO_0009293 | denotes | transduction |
T16041 | 2856-2869 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
GO-MF
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T5086 | 1514-1528 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | immunoglobulin |
T5087 | 1582-1596 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | immunoglobulin |
T5088 | 1735-1743 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibody |
T5089 | 2294-2302 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibody |
T5090 | 2525-2533 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibody |
T5091 | 2662-2670 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibody |
T5092 | 1849-1853 | http://purl.obolibrary.org/obo/GO_0005136 | denotes | IL-4 |
T5093 | 2205-2209 | http://purl.obolibrary.org/obo/GO_0005136 | denotes | IL-4 |
T5094 | 2338-2342 | http://purl.obolibrary.org/obo/GO_0005136 | denotes | IL-4 |
T5095 | 2557-2561 | http://purl.obolibrary.org/obo/GO_0005136 | denotes | IL-4 |
T5096 | 2694-2698 | http://purl.obolibrary.org/obo/GO_0005136 | denotes | IL-4 |
T15597 | 976-984 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibody |
T15598 | 1005-1013 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibody |
T15599 | 1112-1120 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibody |
T15600 | 1173-1181 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibody |
T16042 | 3204-3212 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibody |
T16043 | 3236-3240 | http://purl.obolibrary.org/obo/GO_0005136 | denotes | IL-4 |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T16044 | 2917-2922 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T16045 | 2950-2955 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T16046 | 3067-3072 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T16047 | 3268-3273 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T16048 | 3204-3212 | http://purl.obolibrary.org/obo/GO_0019815 | denotes | antibody |
T16049 | 3204-3212 | http://purl.obolibrary.org/obo/GO_0042571 | denotes | antibody |
T5097 | 126-131 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T5098 | 222-227 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T5099 | 247-252 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T5100 | 464-469 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T5101 | 604-609 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T5102 | 687-692 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T5103 | 764-769 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T5104 | 1442-1447 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T5105 | 1646-1651 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T5106 | 2388-2393 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T5107 | 2486-2491 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T5108 | 2630-2635 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T5109 | 171-183 | http://purl.obolibrary.org/obo/GO_0009986 | denotes | cell surface |
T5110 | 263-266 | http://purl.obolibrary.org/obo/GO_0005680 | denotes | APC |
T5111 | 1735-1743 | http://purl.obolibrary.org/obo/GO_0019815 | denotes | antibody |
T5112 | 2294-2302 | http://purl.obolibrary.org/obo/GO_0019815 | denotes | antibody |
T5113 | 2525-2533 | http://purl.obolibrary.org/obo/GO_0019815 | denotes | antibody |
T5114 | 2662-2670 | http://purl.obolibrary.org/obo/GO_0019815 | denotes | antibody |
T5115 | 1735-1743 | http://purl.obolibrary.org/obo/GO_0042571 | denotes | antibody |
T5116 | 2294-2302 | http://purl.obolibrary.org/obo/GO_0042571 | denotes | antibody |
T5117 | 2525-2533 | http://purl.obolibrary.org/obo/GO_0042571 | denotes | antibody |
T5118 | 2662-2670 | http://purl.obolibrary.org/obo/GO_0042571 | denotes | antibody |
T15601 | 913-918 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T15602 | 976-984 | http://purl.obolibrary.org/obo/GO_0019815 | denotes | antibody |
T15603 | 1005-1013 | http://purl.obolibrary.org/obo/GO_0019815 | denotes | antibody |
T15604 | 1112-1120 | http://purl.obolibrary.org/obo/GO_0019815 | denotes | antibody |
T15605 | 1173-1181 | http://purl.obolibrary.org/obo/GO_0019815 | denotes | antibody |
T15606 | 976-984 | http://purl.obolibrary.org/obo/GO_0042571 | denotes | antibody |
T15607 | 1005-1013 | http://purl.obolibrary.org/obo/GO_0042571 | denotes | antibody |
T15608 | 1112-1120 | http://purl.obolibrary.org/obo/GO_0042571 | denotes | antibody |
T15609 | 1173-1181 | http://purl.obolibrary.org/obo/GO_0042571 | denotes | antibody |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T4245 | 0-101 | Sentence | denotes | HOIP is required for CD40-mediated CD80 upregulation and activation of germline epsilon transcription |
T4246 | 102-267 | Sentence | denotes | Engagement of CD40 on B cells upregulates expression of CD80 [10], a cell surface protein that promotes activation of T cells interacting with B cells and other APC. |
T4247 | 268-479 | Sentence | denotes | To begin evaluating potential contributions of HOIP to CD40 signaling, we assayed the upregulation of CD80 induced by engagement of CD40 on parental A20.2J, HOIP-deficient, and HOIP-reconstituted cells (Fig. 2). |
T4248 | 480-617 | Sentence | denotes | Compared to the parental cell line, the CD40-stimulated upregulation of CD80 was dramatically reduced in all HOIP-deficient cells tested. |
T4249 | 618-805 | Sentence | denotes | In contrast, upregulation of CD80 was restored in HOIP-reconstituted cells, confirming that the defect in CD80 upregulation in the HOIP-deficient cells was due to the disruption of Rnf31. |
T4250 | 1424-1558 | Sentence | denotes | CD40 signals in B cells can also contribute to the activation of DNA recombination in the immunoglobulin heavy chain locus [11], [12]. |
T4251 | 1559-1794 | Sentence | denotes | This process, known as immunoglobulin class switching (or isotype switching), allows B cells, initially expressing IgM, to switch to IgA, IgG, or IgE depending on the class of antibody most appropriate for a particular immune response. |
T4252 | 1795-1871 | Sentence | denotes | Switching to IgE can be induced by the combination of IL-4 and CD40 signals. |
T4253 | 1872-2042 | Sentence | denotes | The gene rearrangement necessary for IgE production is preceded by the production of non-coding RNA transcripts from germline sequences in the IgE heavy chain locus [13]. |
T4254 | 2043-2283 | Sentence | denotes | To determine whether HOIP is required in the initiation of the class switching process, the relevant B cell lines were stimulated through CD40 in the presence of IL-4 and tested for production of germline epsilon (GLε) transcripts (Fig. 3). |
T4255 | 2284-2406 | Sentence | denotes | Anti-CD40 antibody stimulation alone or together with IL-4 induced GLε transcription in parental A20.2J cells as expected. |
T4256 | 2407-2562 | Sentence | denotes | In contrast, only low levels of GLε expression were detected in HOIP-deficient cells stimulated with either anti-CD40 antibody alone or anti-CD40 and IL-4. |
T4257 | 2563-2699 | Sentence | denotes | Normal levels of GLε expression were induced in HOIP-reconstituted cells stimulated with anti-CD40 antibody alone or together with IL-4. |
T4258 | 2700-2807 | Sentence | denotes | Collectively, these data demonstrate that HOIP has a critical role in cellular responses to CD40 signaling. |
T15388 | 850-919 | Sentence | denotes | CD40-mediated CD80 upregulation is defective in HOIP-deficient cells. |
T15389 | 920-1183 | Sentence | denotes | Cells were incubated for 72 hrs with an isotype control antibody (left) or anti-CD40 antibody (right) and then stained for expression of CD80 (filled profiles indicate staining with anti-CD80 antibody; open profiles are staining with an isotype control antibody). |
T15390 | 1184-1367 | Sentence | denotes | Transduction of both HOIP-deficient (HOIP-/-) clones with a retrovirus encoding FLAG-HOIP reversed defective CD80 upregulation, while transduction with an empty vector (pMIP) did not. |
T15391 | 1368-1421 | Sentence | denotes | Similar results were obtained in a second experiment. |
T15736 | 2852-2923 | Sentence | denotes | GLε transcription is defective in CD40-stimulated HOIP-deficient cells. |
T15737 | 2924-3241 | Sentence | denotes | A20.2J and HOIP-deficient cells transduced with an empty retroviral vector (A20.2J + pMIP and HOIP-/- + pMIP, respectively), or HOIP-deficient cells transduced with a HOIP-encoding retrovirus (HOIP-/- + HOIP) were cultured overnight with agonistic anti-CD40 or an isotype control antibody (iso), with or without IL-4. |
T15738 | 3242-3374 | Sentence | denotes | RNA was isolated from the cells, reverse-transcribed, and then subjected to quantitative PCR to determine levels of GLε transcripts. |
T15739 | 3375-3449 | Sentence | denotes | Results were normalized to the levels of Hprt1 transcripts in each sample. |
T15740 | 3450-3548 | Sentence | denotes | Symbols indicate the values from duplicate cultures (a line indicates the mean of the two values). |
T15741 | 3549-3669 | Sentence | denotes | Similar results were obtained in a second experiment and in an additional experiment with a second HOIP-deficient clone. |
T62 | 0-101 | Sentence | denotes | HOIP is required for CD40-mediated CD80 upregulation and activation of germline epsilon transcription |
T63 | 102-267 | Sentence | denotes | Engagement of CD40 on B cells upregulates expression of CD80 [10], a cell surface protein that promotes activation of T cells interacting with B cells and other APC. |
T64 | 268-479 | Sentence | denotes | To begin evaluating potential contributions of HOIP to CD40 signaling, we assayed the upregulation of CD80 induced by engagement of CD40 on parental A20.2J, HOIP-deficient, and HOIP-reconstituted cells (Fig. 2). |
T65 | 480-617 | Sentence | denotes | Compared to the parental cell line, the CD40-stimulated upregulation of CD80 was dramatically reduced in all HOIP-deficient cells tested. |
T66 | 618-805 | Sentence | denotes | In contrast, upregulation of CD80 was restored in HOIP-reconstituted cells, confirming that the defect in CD80 upregulation in the HOIP-deficient cells was due to the disruption of Rnf31. |
T67 | 806-919 | Sentence | denotes | 10.1371/journal.pone.0023061.g002 Figure 2 CD40-mediated CD80 upregulation is defective in HOIP-deficient cells. |
T68 | 920-1183 | Sentence | denotes | Cells were incubated for 72 hrs with an isotype control antibody (left) or anti-CD40 antibody (right) and then stained for expression of CD80 (filled profiles indicate staining with anti-CD80 antibody; open profiles are staining with an isotype control antibody). |
T69 | 1184-1367 | Sentence | denotes | Transduction of both HOIP-deficient (HOIP-/-) clones with a retrovirus encoding FLAG-HOIP reversed defective CD80 upregulation, while transduction with an empty vector (pMIP) did not. |
T70 | 1368-1421 | Sentence | denotes | Similar results were obtained in a second experiment. |
T71 | 1424-1558 | Sentence | denotes | CD40 signals in B cells can also contribute to the activation of DNA recombination in the immunoglobulin heavy chain locus [11], [12]. |
T72 | 1559-1794 | Sentence | denotes | This process, known as immunoglobulin class switching (or isotype switching), allows B cells, initially expressing IgM, to switch to IgA, IgG, or IgE depending on the class of antibody most appropriate for a particular immune response. |
T73 | 1795-1871 | Sentence | denotes | Switching to IgE can be induced by the combination of IL-4 and CD40 signals. |
T74 | 1872-2042 | Sentence | denotes | The gene rearrangement necessary for IgE production is preceded by the production of non-coding RNA transcripts from germline sequences in the IgE heavy chain locus [13]. |
T75 | 2043-2283 | Sentence | denotes | To determine whether HOIP is required in the initiation of the class switching process, the relevant B cell lines were stimulated through CD40 in the presence of IL-4 and tested for production of germline epsilon (GLε) transcripts (Fig. 3). |
T76 | 2284-2406 | Sentence | denotes | Anti-CD40 antibody stimulation alone or together with IL-4 induced GLε transcription in parental A20.2J cells as expected. |
T77 | 2407-2562 | Sentence | denotes | In contrast, only low levels of GLε expression were detected in HOIP-deficient cells stimulated with either anti-CD40 antibody alone or anti-CD40 and IL-4. |
T78 | 2563-2699 | Sentence | denotes | Normal levels of GLε expression were induced in HOIP-reconstituted cells stimulated with anti-CD40 antibody alone or together with IL-4. |
T79 | 2700-2807 | Sentence | denotes | Collectively, these data demonstrate that HOIP has a critical role in cellular responses to CD40 signaling. |
T80 | 2808-2923 | Sentence | denotes | 10.1371/journal.pone.0023061.g003 Figure 3 GLε transcription is defective in CD40-stimulated HOIP-deficient cells. |
T81 | 2924-3241 | Sentence | denotes | A20.2J and HOIP-deficient cells transduced with an empty retroviral vector (A20.2J + pMIP and HOIP-/- + pMIP, respectively), or HOIP-deficient cells transduced with a HOIP-encoding retrovirus (HOIP-/- + HOIP) were cultured overnight with agonistic anti-CD40 or an isotype control antibody (iso), with or without IL-4. |
T82 | 3242-3374 | Sentence | denotes | RNA was isolated from the cells, reverse-transcribed, and then subjected to quantitative PCR to determine levels of GLε transcripts. |
T83 | 3375-3449 | Sentence | denotes | Results were normalized to the levels of Hprt1 transcripts in each sample. |
T84 | 3450-3548 | Sentence | denotes | Symbols indicate the values from duplicate cultures (a line indicates the mean of the two values). |
T85 | 3549-3669 | Sentence | denotes | Similar results were obtained in a second experiment and in an additional experiment with a second HOIP-deficient clone. |
bionlp-st-ge-2016-uniprot
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T5002 | 0-4 | Q96EP0 | denotes | HOIP |
T5003 | 21-25 | P25942 | denotes | CD40 |
T5004 | 35-39 | P33681 | denotes | CD80 |
T5005 | 71-87 | Q28322 | denotes | germline epsilon |
T5006 | 116-120 | P25942 | denotes | CD40 |
T5007 | 158-162 | P33681 | denotes | CD80 |
T5008 | 315-319 | Q96EP0 | denotes | HOIP |
T5009 | 323-327 | P25942 | denotes | CD40 |
T5010 | 370-374 | P33681 | denotes | CD80 |
T5011 | 400-404 | P25942 | denotes | CD40 |
T5012 | 417-420 | P21580 | denotes | A20 |
T5013 | 425-429 | Q96EP0 | denotes | HOIP |
T5014 | 445-449 | Q96EP0 | denotes | HOIP |
T5015 | 520-524 | P25942 | denotes | CD40 |
T5016 | 552-556 | P33681 | denotes | CD80 |
T5017 | 589-593 | Q96EP0 | denotes | HOIP |
T5018 | 647-651 | P33681 | denotes | CD80 |
T5019 | 668-672 | Q96EP0 | denotes | HOIP |
T5020 | 724-728 | P33681 | denotes | CD80 |
T5021 | 749-753 | Q96EP0 | denotes | HOIP |
T5022 | 799-804 | Q96EP0 | denotes | Rnf31 |
T5023 | 1424-1428 | P25942 | denotes | CD40 |
T5024 | 1514-1540 | P01860 | denotes | immunoglobulin heavy chain |
T5025 | 1514-1540 | P01877 | denotes | immunoglobulin heavy chain |
T5026 | 1514-1540 | P01871 | denotes | immunoglobulin heavy chain |
T5027 | 1514-1540 | P01876 | denotes | immunoglobulin heavy chain |
T5028 | 1514-1540 | P01859 | denotes | immunoglobulin heavy chain |
T5029 | 1514-1540 | P01861 | denotes | immunoglobulin heavy chain |
T5030 | 1514-1540 | P01854 | denotes | immunoglobulin heavy chain |
T5031 | 1514-1540 | P01857 | denotes | immunoglobulin heavy chain |
T5032 | 1514-1540 | P01880 | denotes | immunoglobulin heavy chain |
T5033 | 1849-1853 | P05112 | denotes | IL-4 |
T5034 | 1858-1862 | P25942 | denotes | CD40 |
T5035 | 2064-2068 | Q96EP0 | denotes | HOIP |
T5036 | 2181-2185 | P25942 | denotes | CD40 |
T5037 | 2205-2209 | P05112 | denotes | IL-4 |
T5038 | 2239-2255 | Q28322 | denotes | germline epsilon |
T5039 | 2257-2260 | Q28322 | denotes | GLε |
T5040 | 2289-2293 | P25942 | denotes | CD40 |
T5041 | 2338-2342 | P05112 | denotes | IL-4 |
T5042 | 2351-2354 | Q28322 | denotes | GLε |
T5043 | 2381-2384 | P21580 | denotes | A20 |
T5044 | 2439-2442 | Q28322 | denotes | GLε |
T5045 | 2471-2475 | Q96EP0 | denotes | HOIP |
T5046 | 2520-2524 | P25942 | denotes | CD40 |
T5047 | 2548-2552 | P25942 | denotes | CD40 |
T5048 | 2557-2561 | P05112 | denotes | IL-4 |
T5049 | 2580-2583 | Q28322 | denotes | GLε |
T5050 | 2611-2615 | Q96EP0 | denotes | HOIP |
T5051 | 2657-2661 | P25942 | denotes | CD40 |
T5052 | 2694-2698 | P05112 | denotes | IL-4 |
T5053 | 2742-2746 | Q96EP0 | denotes | HOIP |
T5054 | 2792-2796 | P25942 | denotes | CD40 |
T15581 | 850-854 | P25942 | denotes | CD40 |
T15582 | 864-868 | P33681 | denotes | CD80 |
T15583 | 898-902 | Q96EP0 | denotes | HOIP |
T15584 | 1000-1004 | P25942 | denotes | CD40 |
T15585 | 1057-1061 | P33681 | denotes | CD80 |
T15586 | 1107-1111 | P33681 | denotes | CD80 |
T15587 | 1205-1209 | Q96EP0 | denotes | HOIP |
T15588 | 1221-1225 | Q96EP0 | denotes | HOIP |
T15589 | 1269-1273 | Q96EP0 | denotes | HOIP |
T15590 | 1293-1297 | P33681 | denotes | CD80 |
T16020 | 2852-2855 | Q28322 | denotes | GLε |
T16021 | 2886-2890 | P25942 | denotes | CD40 |
T16022 | 2902-2906 | Q96EP0 | denotes | HOIP |
T16023 | 2924-2927 | P21580 | denotes | A20 |
T16024 | 2935-2939 | Q96EP0 | denotes | HOIP |
T16025 | 3000-3003 | P21580 | denotes | A20 |
T16026 | 3018-3022 | Q96EP0 | denotes | HOIP |
T16027 | 3052-3056 | Q96EP0 | denotes | HOIP |
T16028 | 3091-3095 | Q96EP0 | denotes | HOIP |
T16029 | 3117-3121 | Q96EP0 | denotes | HOIP |
T16030 | 3127-3131 | Q96EP0 | denotes | HOIP |
T16031 | 3177-3181 | P25942 | denotes | CD40 |
T16032 | 3236-3240 | P05112 | denotes | IL-4 |
T16033 | 3358-3361 | Q28322 | denotes | GLε |
T16034 | 3648-3652 | Q96EP0 | denotes | HOIP |
test2
Id | Subject | Object | Predicate | Lexical cue | Speculation |
---|---|---|---|---|---|
T4105 | 0-4 | Protein | denotes | HOIP | |
T4106 | 8-16 | Positive_regulation | denotes | required | |
T4107 | 21-25 | Protein | denotes | CD40 | |
T4108 | 26-34 | Positive_regulation | denotes | mediated | |
T4109 | 35-39 | Protein | denotes | CD80 | |
T4110 | 40-52 | Positive_regulation | denotes | upregulation | |
T4111 | 71-87 | Protein | denotes | germline epsilon | |
T4112 | 102-112 | Binding | denotes | Engagement | |
T4113 | 116-120 | Protein | denotes | CD40 | |
T4114 | 132-143 | Positive_regulation | denotes | upregulates | |
T4115 | 144-154 | Gene_expression | denotes | expression | |
T4116 | 158-162 | Protein | denotes | CD80 | true |
T4117 | 315-319 | Protein | denotes | HOIP | |
T4118 | 323-327 | Protein | denotes | CD40 | |
T4119 | 354-366 | Positive_regulation | denotes | upregulation | |
T4120 | 370-374 | Protein | denotes | CD80 | |
T4121 | 375-382 | Positive_regulation | denotes | induced | |
T4122 | 386-396 | Binding | denotes | engagement | |
T4123 | 400-404 | Protein | denotes | CD40 | |
T4124 | 425-429 | Protein | denotes | HOIP | |
T4125 | 430-439 | Negative_regulation | denotes | deficient | |
T4126 | 445-449 | Protein | denotes | HOIP | |
T4127 | 450-463 | Positive_regulation | denotes | reconstituted | |
T4128 | 520-524 | Protein | denotes | CD40 | |
T4129 | 525-535 | Positive_regulation | denotes | stimulated | |
T4130 | 536-548 | Positive_regulation | denotes | upregulation | true |
T4131 | 552-556 | Protein | denotes | CD80 | |
T4132 | 574-581 | Negative_regulation | denotes | reduced | |
T4133 | 589-593 | Protein | denotes | HOIP | |
T4134 | 594-603 | Negative_regulation | denotes | deficient | |
T4135 | 631-643 | Positive_regulation | denotes | upregulation | |
T4136 | 647-651 | Protein | denotes | CD80 | |
T4137 | 668-672 | Protein | denotes | HOIP | |
T4138 | 673-686 | Positive_regulation | denotes | reconstituted | |
T4139 | 714-720 | Negative_regulation | denotes | defect | |
T4140 | 724-728 | Protein | denotes | CD80 | |
T4141 | 729-741 | Positive_regulation | denotes | upregulation | |
T4142 | 749-753 | Protein | denotes | HOIP | |
T4143 | 754-763 | Negative_regulation | denotes | deficient | |
T4144 | 774-777 | Positive_regulation | denotes | due | |
T4145 | 785-795 | Negative_regulation | denotes | disruption | |
T4146 | 799-804 | Protein | denotes | Rnf31 | |
T4147 | 1424-1428 | Protein | denotes | CD40 | |
T4148 | 1819-1826 | Positive_regulation | denotes | induced | |
T4149 | 1849-1853 | Protein | denotes | IL-4 | |
T4150 | 1858-1862 | Protein | denotes | CD40 | |
T4151 | 2064-2068 | Protein | denotes | HOIP | |
T4152 | 2181-2185 | Protein | denotes | CD40 | |
T4153 | 2205-2209 | Protein | denotes | IL-4 | |
T4154 | 2225-2235 | Gene_expression | denotes | production | |
T4155 | 2239-2255 | Protein | denotes | germline epsilon | |
T4156 | 2257-2260 | Protein | denotes | GLε | |
T4157 | 2338-2342 | Protein | denotes | IL-4 | |
T4158 | 2343-2350 | Positive_regulation | denotes | induced | |
T4159 | 2351-2354 | Protein | denotes | GLε | |
T4160 | 2355-2368 | Transcription | denotes | transcription | |
T4161 | 2439-2442 | Protein | denotes | GLε | |
T4162 | 2443-2453 | Gene_expression | denotes | expression | |
T4163 | 2471-2475 | Protein | denotes | HOIP | |
T4164 | 2476-2485 | Negative_regulation | denotes | deficient | |
T4165 | 2557-2561 | Protein | denotes | IL-4 | |
T4166 | 2580-2583 | Protein | denotes | GLε | |
T4167 | 2584-2594 | Gene_expression | denotes | expression | |
T4168 | 2600-2607 | Positive_regulation | denotes | induced | |
T4169 | 2611-2615 | Protein | denotes | HOIP | |
T4170 | 2616-2629 | Positive_regulation | denotes | reconstituted | |
T4171 | 2694-2698 | Protein | denotes | IL-4 | |
T4172 | 2742-2746 | Protein | denotes | HOIP | |
T4173 | 2792-2796 | Protein | denotes | CD40 | |
T15355 | 850-854 | Protein | denotes | CD40 | |
T15356 | 855-863 | Positive_regulation | denotes | mediated | |
T15357 | 864-868 | Protein | denotes | CD80 | |
T15358 | 869-881 | Positive_regulation | denotes | upregulation | |
T15359 | 885-894 | Negative_regulation | denotes | defective | true |
T15360 | 898-902 | Protein | denotes | HOIP | |
T15361 | 903-912 | Negative_regulation | denotes | deficient | |
T15362 | 1043-1053 | Gene_expression | denotes | expression | |
T15363 | 1057-1061 | Protein | denotes | CD80 | |
T15364 | 1205-1209 | Protein | denotes | HOIP | |
T15365 | 1210-1219 | Negative_regulation | denotes | deficient | |
T15366 | 1221-1225 | Protein | denotes | HOIP | |
T15367 | 1269-1273 | Protein | denotes | HOIP | |
T15368 | 1283-1292 | Negative_regulation | denotes | defective | |
T15369 | 1293-1297 | Protein | denotes | CD80 | |
T15370 | 1298-1310 | Positive_regulation | denotes | upregulation | |
T15696 | 2852-2855 | Protein | denotes | GLε | |
T15697 | 2856-2869 | Transcription | denotes | transcription | |
T15698 | 2886-2890 | Protein | denotes | CD40 | |
T15699 | 2902-2906 | Protein | denotes | HOIP | |
T15700 | 2907-2916 | Negative_regulation | denotes | deficient | |
T15701 | 2935-2939 | Protein | denotes | HOIP | true |
T15702 | 2940-2949 | Negative_regulation | denotes | deficient | |
T15703 | 3018-3022 | Protein | denotes | HOIP | |
T15704 | 3052-3056 | Protein | denotes | HOIP | |
T15705 | 3057-3066 | Negative_regulation | denotes | deficient | |
T15706 | 3091-3095 | Protein | denotes | HOIP | |
T15707 | 3117-3121 | Protein | denotes | HOIP | |
T15708 | 3127-3131 | Protein | denotes | HOIP | |
T15709 | 3236-3240 | Protein | denotes | IL-4 | |
T15710 | 3358-3361 | Protein | denotes | GLε | |
T15711 | 3416-3421 | Protein | denotes | Hprt1 | |
T15712 | 3422-3433 | Transcription | denotes | transcripts | |
T15713 | 3648-3652 | Protein | denotes | HOIP | |
T15714 | 3653-3662 | Negative_regulation | denotes | deficient | |
R3163 | T4105 | T4106 | causeOf | HOIP,required | |
R3164 | T4107 | T4108 | causeOf | CD40,mediated | |
R3165 | T4108 | T4106 | themeOf | mediated,required | |
R3166 | T4109 | T4110 | themeOf | CD80,upregulation | |
R3167 | T4110 | T4108 | themeOf | upregulation,mediated | |
R3168 | T4112 | T4114 | causeOf | Engagement,upregulates | |
R3169 | T4113 | T4112 | themeOf | CD40,Engagement | |
R3170 | T4115 | T4114 | themeOf | expression,upregulates | |
R3171 | T4116 | T4115 | themeOf | CD80,expression | |
R3172 | T4119 | T4121 | themeOf | upregulation,induced | |
R3173 | T4120 | T4119 | themeOf | CD80,upregulation | |
R3174 | T4122 | T4121 | causeOf | engagement,induced | |
R3175 | T4123 | T4122 | themeOf | CD40,engagement | |
R3176 | T4124 | T4125 | themeOf | HOIP,deficient | |
R3177 | T4126 | T4127 | themeOf | HOIP,reconstituted | |
R3178 | T4128 | T4129 | causeOf | CD40,stimulated | |
R3179 | T4129 | T4132 | themeOf | stimulated,reduced | |
R3180 | T4130 | T4129 | themeOf | upregulation,stimulated | |
R3181 | T4130 | T4132 | themeOf | upregulation,reduced | |
R3182 | T4131 | T4130 | themeOf | CD80,upregulation | |
R3183 | T4133 | T4134 | themeOf | HOIP,deficient | |
R3184 | T4134 | T4132 | causeOf | deficient,reduced | |
R3185 | T4136 | T4135 | themeOf | CD80,upregulation | |
R3186 | T4137 | T4138 | themeOf | HOIP,reconstituted | |
R3187 | T4139 | T4144 | themeOf | defect,due | |
R3188 | T4140 | T4141 | themeOf | CD80,upregulation | |
R3189 | T4141 | T4144 | themeOf | upregulation,due | |
R3190 | T4141 | T4139 | themeOf | upregulation,defect | |
R3191 | T4142 | T4143 | themeOf | HOIP,deficient | |
R3192 | T4143 | T4139 | causeOf | deficient,defect | |
R3193 | T4145 | T4144 | causeOf | disruption,due | |
R3194 | T4145 | T4139 | causeOf | disruption,defect | |
R3195 | T4146 | T4145 | themeOf | Rnf31,disruption | |
R3196 | T4155 | T4154 | themeOf | germline epsilon,production | |
R3197 | T4156 | T4155 | equivalentTo | GLε,germline epsilon | |
R3198 | T4157 | T4158 | causeOf | IL-4,induced | |
R3199 | T4159 | T4160 | themeOf | GLε,transcription | |
R3200 | T4160 | T4158 | themeOf | transcription,induced | |
R3201 | T4161 | T4162 | themeOf | GLε,expression | |
R3202 | T4163 | T4164 | themeOf | HOIP,deficient | |
R3203 | T4166 | T4167 | themeOf | GLε,expression | |
R3204 | T4167 | T4168 | themeOf | expression,induced | |
R3205 | T4169 | T4170 | themeOf | HOIP,reconstituted | |
R3206 | T4170 | T4168 | causeOf | reconstituted,induced | |
R12159 | T15355 | T15356 | causeOf | CD40,mediated | |
R12160 | T15356 | T15359 | themeOf | mediated,defective | |
R12161 | T15357 | T15358 | themeOf | CD80,upregulation | |
R12162 | T15358 | T15356 | themeOf | upregulation,mediated | |
R12163 | T15358 | T15359 | themeOf | upregulation,defective | |
R12164 | T15360 | T15361 | themeOf | HOIP,deficient | |
R12165 | T15361 | T15359 | causeOf | deficient,defective | |
R12166 | T15363 | T15362 | themeOf | CD80,expression | |
R12167 | T15364 | T15365 | themeOf | HOIP,deficient | |
R12168 | T15369 | T15370 | themeOf | CD80,upregulation | |
R12169 | T15370 | T15368 | themeOf | upregulation,defective | |
R12415 | T15696 | T15697 | themeOf | GLε,transcription | |
R12416 | T15699 | T15700 | themeOf | HOIP,deficient | |
R12417 | T15701 | T15702 | themeOf | HOIP,deficient | |
R12418 | T15704 | T15705 | themeOf | HOIP,deficient | |
R12419 | T15711 | T15712 | themeOf | Hprt1,transcripts | |
R12420 | T15713 | T15714 | themeOf | HOIP,deficient |