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PMC:3148254 / 8815-12487 JSONTXT

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bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Speculation
T4174 0-4 Protein denotes HOIP
T4175 8-16 Positive_regulation denotes required
T4176 8-16 Positive_regulation denotes required
T4177 21-25 Protein denotes CD40
T4178 26-34 Positive_regulation denotes mediated
T4179 26-34 Positive_regulation denotes mediated
T4180 35-39 Protein denotes CD80
T4181 40-52 Positive_regulation denotes upregulation
T4182 57-67 Positive_regulation denotes activation
T4183 71-87 Protein denotes germline epsilon
T4184 88-101 Transcription denotes transcription
T4185 102-112 Binding denotes Engagement
T4186 116-120 Protein denotes CD40
T4187 132-143 Positive_regulation denotes upregulates
T4188 144-154 Gene_expression denotes expression
T4189 158-162 Protein denotes CD80
T4190 315-319 Protein denotes HOIP
T4191 323-327 Protein denotes CD40
T4192 354-366 Positive_regulation denotes upregulation
T4193 370-374 Protein denotes CD80
T4194 375-382 Positive_regulation denotes induced true
T4195 386-396 Binding denotes engagement
T4196 400-404 Protein denotes CD40
T4197 425-429 Protein denotes HOIP
T4198 445-449 Protein denotes HOIP
T4199 450-463 Positive_regulation denotes reconstituted
T4200 520-524 Protein denotes CD40
T4201 525-535 Positive_regulation denotes stimulated
T4202 536-548 Positive_regulation denotes upregulation
T4203 552-556 Protein denotes CD80
T4204 574-581 Negative_regulation denotes reduced
T4205 589-593 Protein denotes HOIP
T4206 594-603 Negative_regulation denotes deficient
T4207 631-643 Positive_regulation denotes upregulation
T4208 647-651 Protein denotes CD80
T4209 668-672 Protein denotes HOIP
T4210 673-686 Positive_regulation denotes reconstituted
T4211 714-720 Negative_regulation denotes defect
T4212 724-728 Protein denotes CD80
T4213 729-741 Positive_regulation denotes upregulation
T4214 749-753 Protein denotes HOIP
T4215 754-763 Negative_regulation denotes deficient
T4216 774-777 Positive_regulation denotes due
T4217 785-795 Negative_regulation denotes disruption
T4218 799-804 Protein denotes Rnf31
T4219 1424-1428 Protein denotes CD40
T4220 1849-1853 Protein denotes IL-4
T4221 1858-1862 Protein denotes CD40
T4222 2064-2068 Protein denotes HOIP
T4223 2181-2185 Protein denotes CD40
T4224 2205-2209 Protein denotes IL-4
T4225 2225-2235 Transcription denotes production true
T4226 2239-2255 Protein denotes germline epsilon
T4227 2257-2260 Protein denotes GLε
T4228 2338-2342 Protein denotes IL-4
T4229 2343-2350 Positive_regulation denotes induced
T4230 2351-2354 Protein denotes GLε
T4231 2355-2368 Transcription denotes transcription
T4232 2439-2442 Protein denotes GLε
T4233 2443-2453 Gene_expression denotes expression
T4234 2471-2475 Protein denotes HOIP
T4235 2476-2485 Negative_regulation denotes deficient
T4236 2557-2561 Protein denotes IL-4
T4237 2580-2583 Protein denotes GLε
T4238 2584-2594 Gene_expression denotes expression
T4239 2600-2607 Positive_regulation denotes induced
T4240 2611-2615 Protein denotes HOIP
T4241 2616-2629 Positive_regulation denotes reconstituted
T4242 2694-2698 Protein denotes IL-4
T4243 2742-2746 Protein denotes HOIP
T4244 2792-2796 Protein denotes CD40
T15371 850-854 Protein denotes CD40
T15372 855-863 Positive_regulation denotes mediated
T15373 864-868 Protein denotes CD80
T15374 869-881 Positive_regulation denotes upregulation
T15375 885-894 Negative_regulation denotes defective
T15376 898-902 Protein denotes HOIP
T15377 903-912 Negative_regulation denotes deficient
T15378 1043-1053 Gene_expression denotes expression true
T15379 1057-1061 Protein denotes CD80
T15380 1205-1209 Protein denotes HOIP
T15381 1210-1219 Negative_regulation denotes deficient
T15382 1221-1225 Protein denotes HOIP
T15383 1269-1273 Protein denotes HOIP
T15384 1274-1282 Negative_regulation denotes reversed
T15385 1283-1292 Negative_regulation denotes defective
T15386 1293-1297 Protein denotes CD80
T15387 1298-1310 Positive_regulation denotes upregulation
T15715 2852-2855 Protein denotes GLε
T15716 2856-2869 Transcription denotes transcription
T15717 2873-2882 Negative_regulation denotes defective
T15718 2886-2890 Protein denotes CD40
T15719 2902-2906 Protein denotes HOIP
T15720 2907-2916 Negative_regulation denotes deficient
T15721 2935-2939 Protein denotes HOIP
T15722 2940-2949 Negative_regulation denotes deficient
T15723 3018-3022 Protein denotes HOIP
T15724 3052-3056 Protein denotes HOIP
T15725 3057-3066 Negative_regulation denotes deficient
T15726 3091-3095 Protein denotes HOIP
T15727 3117-3121 Protein denotes HOIP
T15728 3127-3131 Protein denotes HOIP
T15729 3236-3240 Protein denotes IL-4
T15730 3358-3361 Protein denotes GLε
T15731 3362-3373 Transcription denotes transcripts true
T15732 3416-3421 Protein denotes Hprt1
T15733 3422-3433 Transcription denotes transcripts
T15734 3648-3652 Protein denotes HOIP
T15735 3653-3662 Negative_regulation denotes deficient
R3207 T4174 T4176 causeOf HOIP,required
R3208 T4174 T4175 causeOf HOIP,required
R3209 T4178 T4175 themeOf mediated,required
R3210 T4179 T4176 themeOf mediated,required
R3211 T4180 T4181 themeOf CD80,upregulation
R3212 T4181 T4179 themeOf upregulation,mediated
R3213 T4182 T4178 themeOf activation,mediated
R3214 T4183 T4184 themeOf germline epsilon,transcription
R3215 T4184 T4182 themeOf transcription,activation
R3216 T4185 T4187 causeOf Engagement,upregulates
R3217 T4186 T4185 themeOf CD40,Engagement
R3218 T4188 T4187 themeOf expression,upregulates
R3219 T4189 T4188 themeOf CD80,expression
R3220 T4192 T4194 themeOf upregulation,induced
R3221 T4193 T4192 themeOf CD80,upregulation
R3222 T4195 T4194 causeOf engagement,induced
R3223 T4196 T4195 themeOf CD40,engagement
R3224 T4198 T4199 themeOf HOIP,reconstituted
R3225 T4200 T4201 causeOf CD40,stimulated
R3226 T4202 T4201 themeOf upregulation,stimulated
R3227 T4202 T4204 themeOf upregulation,reduced
R3228 T4203 T4202 themeOf CD80,upregulation
R3229 T4205 T4206 themeOf HOIP,deficient
R3230 T4206 T4204 causeOf deficient,reduced
R3231 T4208 T4207 themeOf CD80,upregulation
R3232 T4209 T4210 themeOf HOIP,reconstituted
R3233 T4211 T4216 themeOf defect,due
R3234 T4212 T4213 themeOf CD80,upregulation
R3235 T4213 T4211 themeOf upregulation,defect
R3236 T4214 T4215 themeOf HOIP,deficient
R3237 T4215 T4211 causeOf deficient,defect
R3238 T4217 T4216 causeOf disruption,due
R3239 T4218 T4217 themeOf Rnf31,disruption
R3240 T4226 T4225 themeOf germline epsilon,production
R3241 T4227 T4226 equivalentTo GLε,germline epsilon
R3242 T4230 T4231 themeOf GLε,transcription
R3243 T4231 T4229 themeOf transcription,induced
R3244 T4232 T4233 themeOf GLε,expression
R3245 T4234 T4235 themeOf HOIP,deficient
R3246 T4237 T4238 themeOf GLε,expression
R3247 T4238 T4239 themeOf expression,induced
R3248 T4240 T4241 themeOf HOIP,reconstituted
R12170 T15371 T15372 causeOf CD40,mediated
R12171 T15372 T15375 themeOf mediated,defective
R12172 T15373 T15374 themeOf CD80,upregulation
R12173 T15374 T15372 themeOf upregulation,mediated
R12174 T15376 T15377 themeOf HOIP,deficient
R12175 T15379 T15378 themeOf CD80,expression
R12176 T15380 T15381 themeOf HOIP,deficient
R12177 T15385 T15384 themeOf defective,reversed
R12178 T15386 T15387 themeOf CD80,upregulation
R12179 T15387 T15385 themeOf upregulation,defective
R12421 T15715 T15716 themeOf GLε,transcription
R12422 T15716 T15717 themeOf transcription,defective
R12423 T15719 T15720 themeOf HOIP,deficient
R12424 T15721 T15722 themeOf HOIP,deficient
R12425 T15724 T15725 themeOf HOIP,deficient
R12426 T15730 T15731 themeOf GLε,transcripts
R12427 T15732 T15733 themeOf Hprt1,transcripts
R12428 T15734 T15735 themeOf HOIP,deficient

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T5261 21-25 Protein denotes CD40
T5262 35-39 Protein denotes CD80
T5263 71-87 Protein denotes germline epsilon
T5264 40-52 Positive_regulation denotes upregulation
T5265 88-101 Transcription denotes transcription
T5266 57-67 Positive_regulation denotes activation
T5267 8-16 Positive_regulation denotes required
T5268 116-120 Protein denotes CD40
T5269 158-162 Protein denotes CD80
T5270 102-112 Binding denotes Engagement
T5271 144-154 Gene_expression denotes expression
T5272 132-143 Positive_regulation denotes upregulates
T5273 323-327 Protein denotes CD40
T5274 370-374 Protein denotes CD80
T5275 400-404 Protein denotes CD40
T5276 354-366 Positive_regulation denotes upregulation
T5277 386-396 Binding denotes engagement
T5278 520-524 Protein denotes CD40
T5279 552-556 Protein denotes CD80
T5280 536-548 Positive_regulation denotes upregulation
T5281 574-581 Negative_regulation denotes reduced
T5282 647-651 Protein denotes CD80
T5283 724-728 Protein denotes CD80
T5284 799-804 Protein denotes Rnf31
T5285 631-643 Positive_regulation denotes upregulation
T5286 729-741 Positive_regulation denotes upregulation
T5287 785-795 Negative_regulation denotes disruption
T5288 714-720 Negative_regulation denotes defect
T5289 1424-1428 Protein denotes CD40
T5290 1514-1528 Protein denotes immunoglobulin
T5291 1582-1596 Protein denotes immunoglobulin
T5292 1674-1677 Protein denotes IgM
T5293 1692-1695 Protein denotes IgA
T5294 1697-1700 Protein denotes IgG
T5295 1705-1708 Protein denotes IgE
T5296 1663-1673 Gene_expression denotes expressing
T5297 1682-1688 Binding denotes switch
T5298 1808-1811 Protein denotes IgE
T5299 1849-1853 Protein denotes IL-4
T5300 1858-1870 Protein denotes CD40 signals
T5301 1834-1845 Binding denotes combination
T5302 1819-1826 Positive_regulation denotes induced
T5303 1909-1912 Protein denotes IgE
T5304 2015-2018 Protein denotes IgE
T5305 1913-1923 Gene_expression denotes production
T5306 1895-1904 Positive_regulation denotes necessary
T5307 2181-2185 Protein denotes CD40
T5308 2205-2209 Protein denotes IL-4
T5309 2284-2302 Protein denotes Anti-CD40 antibody
T5310 2338-2342 Protein denotes IL-4
T5311 2303-2314 Positive_regulation denotes stimulation
T5312 2520-2524 Protein denotes CD40
T5313 2548-2552 Protein denotes CD40
T5314 2557-2561 Protein denotes IL-4
T5315 2652-2670 Protein denotes anti-CD40 antibody
T5316 2792-2796 Protein denotes CD40
T15644 850-854 Protein denotes CD40
T15645 864-868 Protein denotes CD80
T15646 869-881 Positive_regulation denotes upregulation
T15647 885-894 Negative_regulation denotes defective
T15648 855-863 Positive_regulation denotes mediated
T15649 960-984 Protein denotes isotype control antibody
T15650 1000-1004 Protein denotes CD40
T15651 1057-1061 Protein denotes CD80
T15652 1107-1111 Protein denotes CD80
T15653 1157-1181 Protein denotes isotype control antibody
T15654 1043-1053 Gene_expression denotes expression
T15655 1293-1297 Protein denotes CD80
T15656 1298-1310 Positive_regulation denotes upregulation
T15657 1274-1282 Negative_regulation denotes reversed
T16092 2886-2890 Protein denotes CD40
T16093 3177-3181 Protein denotes CD40
T16094 3188-3212 Protein denotes isotype control antibody
T16095 3214-3217 Protein denotes iso
T16096 3236-3240 Protein denotes IL-4
T16097 3358-3373 Protein denotes GLε transcripts
T16098 3416-3433 Protein denotes Hprt1 transcripts
R4084 T5262 T5264 themeOf CD80,upregulation
R4085 T5263 T5265 themeOf germline epsilon,transcription
R4086 T5265 T5266 themeOf transcription,activation
R4087 T5266 T5267 themeOf activation,required
R4088 T5268 T5270 themeOf CD40,Engagement
R4089 T5269 T5271 themeOf CD80,expression
R4090 T5270 T5272 causeOf Engagement,upregulates
R4091 T5271 T5272 themeOf expression,upregulates
R4092 T5274 T5276 themeOf CD80,upregulation
R4093 T5275 T5277 themeOf CD40,engagement
R4094 T5278 T5280 causeOf CD40,upregulation
R4095 T5279 T5280 themeOf CD80,upregulation
R4096 T5280 T5281 themeOf upregulation,reduced
R4097 T5282 T5285 themeOf CD80,upregulation
R4098 T5283 T5286 themeOf CD80,upregulation
R4099 T5284 T5287 themeOf Rnf31,disruption
R4100 T5286 T5288 themeOf upregulation,defect
R4101 T5292 T5296 themeOf IgM,expressing
R4102 T5295 T5297 themeOf IgE,switch
R4103 T5298 T5302 themeOf IgE,induced
R4104 T5300 T5301 themeOf CD40 signals,combination
R4105 T5301 T5302 causeOf combination,induced
R4106 T5303 T5305 themeOf IgE,production
R4107 T5305 T5306 themeOf production,necessary
R4108 T5309 T5311 themeOf Anti-CD40 antibody,stimulation
R12390 T15644 T15648 causeOf CD40,mediated
R12391 T15645 T15646 themeOf CD80,upregulation
R12392 T15646 T15647 themeOf upregulation,defective
R12393 T15646 T15648 themeOf upregulation,mediated
R12394 T15651 T15654 themeOf CD80,expression
R12395 T15655 T15656 themeOf CD80,upregulation
R12396 T15656 T15657 themeOf upregulation,reversed

events-check-again

Id Subject Object Predicate Lexical cue Speculation
T5317 0-4 Protein denotes HOIP
T5318 8-16 Positive_regulation denotes required
T5319 8-16 Positive_regulation denotes required
T5320 21-25 Protein denotes CD40
T5321 26-34 Positive_regulation denotes mediated
T5322 26-34 Positive_regulation denotes mediated
T5323 35-39 Protein denotes CD80
T5324 40-52 Positive_regulation denotes upregulation
T5325 57-67 Positive_regulation denotes activation
T5326 71-87 Protein denotes germline epsilon
T5327 88-101 Transcription denotes transcription
T5328 102-112 Binding denotes Engagement
T5329 116-120 Protein denotes CD40
T5330 132-143 Positive_regulation denotes upregulates
T5331 144-154 Gene_expression denotes expression
T5332 158-162 Protein denotes CD80
T5333 315-319 Protein denotes HOIP
T5334 323-327 Protein denotes CD40
T5335 354-366 Positive_regulation denotes upregulation
T5336 370-374 Protein denotes CD80
T5337 375-382 Positive_regulation denotes induced true
T5338 386-396 Binding denotes engagement
T5339 400-404 Protein denotes CD40
T5340 425-429 Protein denotes HOIP
T5341 445-449 Protein denotes HOIP
T5342 450-463 Positive_regulation denotes reconstituted
T5343 520-524 Protein denotes CD40
T5344 525-535 Positive_regulation denotes stimulated
T5345 536-548 Positive_regulation denotes upregulation
T5346 552-556 Protein denotes CD80
T5347 574-581 Negative_regulation denotes reduced
T5348 589-593 Protein denotes HOIP
T5349 594-603 Negative_regulation denotes deficient
T5350 631-643 Positive_regulation denotes upregulation
T5351 647-651 Protein denotes CD80
T5352 668-672 Protein denotes HOIP
T5353 673-686 Positive_regulation denotes reconstituted
T5354 714-720 Negative_regulation denotes defect
T5355 724-728 Protein denotes CD80
T5356 729-741 Positive_regulation denotes upregulation
T5357 749-753 Protein denotes HOIP
T5358 754-763 Negative_regulation denotes deficient
T5359 774-777 Positive_regulation denotes due
T5360 785-795 Negative_regulation denotes disruption
T5361 799-804 Protein denotes Rnf31
T5362 1424-1428 Protein denotes CD40
T5363 1849-1853 Protein denotes IL-4
T5364 1858-1862 Protein denotes CD40
T5365 2064-2068 Protein denotes HOIP
T5366 2181-2185 Protein denotes CD40
T5367 2205-2209 Protein denotes IL-4
T5368 2225-2235 Transcription denotes production true
T5369 2239-2255 Protein denotes germline epsilon
T5370 2257-2260 Protein denotes GLε
T5371 2338-2342 Protein denotes IL-4
T5372 2343-2350 Positive_regulation denotes induced
T5373 2351-2354 Protein denotes GLε
T5374 2355-2368 Transcription denotes transcription
T5375 2439-2442 Protein denotes GLε
T5376 2443-2453 Gene_expression denotes expression
T5377 2471-2475 Protein denotes HOIP
T5378 2476-2485 Negative_regulation denotes deficient
T5379 2557-2561 Protein denotes IL-4
T5380 2580-2583 Protein denotes GLε
T5381 2584-2594 Gene_expression denotes expression
T5382 2600-2607 Positive_regulation denotes induced
T5383 2611-2615 Protein denotes HOIP
T5384 2616-2629 Positive_regulation denotes reconstituted
T5385 2694-2698 Protein denotes IL-4
T5386 2742-2746 Protein denotes HOIP
T5387 2792-2796 Protein denotes CD40
T15658 850-854 Protein denotes CD40
T15659 855-863 Positive_regulation denotes mediated
T15660 864-868 Protein denotes CD80
T15661 869-881 Positive_regulation denotes upregulation
T15662 885-894 Negative_regulation denotes defective
T15663 898-902 Protein denotes HOIP
T15664 903-912 Negative_regulation denotes deficient
T15665 1043-1053 Gene_expression denotes expression true
T15666 1057-1061 Protein denotes CD80
T15667 1205-1209 Protein denotes HOIP
T15668 1210-1219 Negative_regulation denotes deficient
T15669 1221-1225 Protein denotes HOIP
T15670 1269-1273 Protein denotes HOIP
T15671 1274-1282 Negative_regulation denotes reversed
T15672 1283-1292 Negative_regulation denotes defective
T15673 1293-1297 Protein denotes CD80
T15674 1298-1310 Positive_regulation denotes upregulation
T16099 2852-2855 Protein denotes GLε
T16100 2856-2869 Transcription denotes transcription
T16101 2873-2882 Negative_regulation denotes defective
T16102 2886-2890 Protein denotes CD40
T16103 2902-2906 Protein denotes HOIP
T16104 2907-2916 Negative_regulation denotes deficient
T16105 2935-2939 Protein denotes HOIP
T16106 2940-2949 Negative_regulation denotes deficient
T16107 3018-3022 Protein denotes HOIP
T16108 3052-3056 Protein denotes HOIP
T16109 3057-3066 Negative_regulation denotes deficient
T16110 3091-3095 Protein denotes HOIP
T16111 3117-3121 Protein denotes HOIP
T16112 3127-3131 Protein denotes HOIP
T16113 3236-3240 Protein denotes IL-4
T16114 3358-3361 Protein denotes GLε
T16115 3362-3373 Transcription denotes transcripts true
T16116 3416-3421 Protein denotes Hprt1
T16117 3422-3433 Transcription denotes transcripts
T16118 3648-3652 Protein denotes HOIP
T16119 3653-3662 Negative_regulation denotes deficient
R4109 T5317 T5319 causeOf HOIP,required
R4110 T5317 T5318 causeOf HOIP,required
R4111 T5321 T5318 themeOf mediated,required
R4112 T5322 T5319 themeOf mediated,required
R4113 T5323 T5324 themeOf CD80,upregulation
R4114 T5324 T5322 themeOf upregulation,mediated
R4115 T5325 T5321 themeOf activation,mediated
R4116 T5326 T5327 themeOf germline epsilon,transcription
R4117 T5327 T5325 themeOf transcription,activation
R4118 T5328 T5330 causeOf Engagement,upregulates
R4119 T5329 T5328 themeOf CD40,Engagement
R4120 T5331 T5330 themeOf expression,upregulates
R4121 T5332 T5331 themeOf CD80,expression
R4122 T5335 T5337 themeOf upregulation,induced
R4123 T5336 T5335 themeOf CD80,upregulation
R4124 T5338 T5337 causeOf engagement,induced
R4125 T5339 T5338 themeOf CD40,engagement
R4126 T5341 T5342 themeOf HOIP,reconstituted
R4127 T5343 T5344 causeOf CD40,stimulated
R4128 T5345 T5344 themeOf upregulation,stimulated
R4129 T5345 T5347 themeOf upregulation,reduced
R4130 T5346 T5345 themeOf CD80,upregulation
R4131 T5348 T5349 themeOf HOIP,deficient
R4132 T5349 T5347 causeOf deficient,reduced
R4133 T5351 T5350 themeOf CD80,upregulation
R4134 T5352 T5353 themeOf HOIP,reconstituted
R4135 T5354 T5359 themeOf defect,due
R4136 T5355 T5356 themeOf CD80,upregulation
R4137 T5356 T5354 themeOf upregulation,defect
R4138 T5357 T5358 themeOf HOIP,deficient
R4139 T5358 T5354 causeOf deficient,defect
R4140 T5360 T5359 causeOf disruption,due
R4141 T5361 T5360 themeOf Rnf31,disruption
R4142 T5369 T5368 themeOf germline epsilon,production
R4143 T5370 T5369 equivalentTo GLε,germline epsilon
R4144 T5373 T5374 themeOf GLε,transcription
R4145 T5374 T5372 themeOf transcription,induced
R4146 T5375 T5376 themeOf GLε,expression
R4147 T5377 T5378 themeOf HOIP,deficient
R4148 T5380 T5381 themeOf GLε,expression
R4149 T5381 T5382 themeOf expression,induced
R4150 T5383 T5384 themeOf HOIP,reconstituted
R12397 T15658 T15659 causeOf CD40,mediated
R12398 T15659 T15662 themeOf mediated,defective
R12399 T15660 T15661 themeOf CD80,upregulation
R12400 T15661 T15659 themeOf upregulation,mediated
R12401 T15663 T15664 themeOf HOIP,deficient
R12402 T15666 T15665 themeOf CD80,expression
R12403 T15667 T15668 themeOf HOIP,deficient
R12404 T15672 T15671 themeOf defective,reversed
R12405 T15673 T15674 themeOf CD80,upregulation
R12406 T15674 T15672 themeOf upregulation,defective
R12727 T16099 T16100 themeOf GLε,transcription
R12728 T16100 T16101 themeOf transcription,defective
R12729 T16103 T16104 themeOf HOIP,deficient
R12730 T16105 T16106 themeOf HOIP,deficient
R12731 T16108 T16109 themeOf HOIP,deficient
R12732 T16114 T16115 themeOf GLε,transcripts
R12733 T16116 T16117 themeOf Hprt1,transcripts
R12734 T16118 T16119 themeOf HOIP,deficient

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T4639 0-4 NN denotes HOIP
T4640 5-7 VB denotes is
T4641 8-16 VB denotes required
T4642 17-20 IN denotes for
T4643 21-34 JJ denotes CD40-mediated
T4644 35-39 NN denotes CD80
T4645 40-52 NN denotes upregulation
T4646 53-56 CC denotes and
T4647 57-67 NN denotes activation
T4648 68-70 IN denotes of
T4649 71-79 NN denotes germline
T4650 80-87 NN denotes epsilon
T4651 88-101 NN denotes transcription
T4652 102-112 NN denotes Engagement
T4653 113-115 IN denotes of
T4654 116-120 NN denotes CD40
T4655 121-123 IN denotes on
T4656 124-125 NN denotes B
T4657 126-131 NN denotes cells
T4658 132-143 VB denotes upregulates
T4659 144-154 NN denotes expression
T4660 155-157 IN denotes of
T4661 158-162 NN denotes CD80
T4662 163-164 -LRB- denotes [
T4663 164-166 CD denotes 10
T4664 166-167 -RRB- denotes ]
T4665 167-168 -COMMA- denotes ,
T4666 169-170 DT denotes a
T4667 171-175 NN denotes cell
T4668 176-183 NN denotes surface
T4669 184-191 NN denotes protein
T4670 192-196 WDT denotes that
T4671 197-205 VB denotes promotes
T4672 206-216 NN denotes activation
T4673 217-219 IN denotes of
T4674 220-221 NN denotes T
T4675 222-227 NN denotes cells
T4676 228-239 VB denotes interacting
T4677 240-244 IN denotes with
T4678 245-246 NN denotes B
T4679 247-252 NN denotes cells
T4680 253-256 CC denotes and
T4681 257-262 JJ denotes other
T4682 263-266 NN denotes APC
T4683 268-270 TO denotes To
T4684 271-276 VB denotes begin
T4685 277-287 VB denotes evaluating
T4686 288-297 JJ denotes potential
T4687 298-311 NN denotes contributions
T4688 312-314 IN denotes of
T4689 315-319 NN denotes HOIP
T4690 320-322 TO denotes to
T4691 323-327 NN denotes CD40
T4692 328-337 NN denotes signaling
T4693 337-338 -COMMA- denotes ,
T4694 339-341 PRP denotes we
T4695 342-349 VB denotes assayed
T4696 350-353 DT denotes the
T4697 354-366 NN denotes upregulation
T4698 367-369 IN denotes of
T4699 370-374 NN denotes CD80
T4700 375-382 VB denotes induced
T4701 383-385 IN denotes by
T4702 386-396 NN denotes engagement
T4703 397-399 IN denotes of
T4704 400-404 NN denotes CD40
T4705 405-407 IN denotes on
T4706 408-416 JJ denotes parental
T4707 417-423 NN denotes A20.2J
T4708 423-424 -COMMA- denotes ,
T4709 425-439 JJ denotes HOIP-deficient
T4710 439-440 -COMMA- denotes ,
T4711 441-444 CC denotes and
T4712 445-463 JJ denotes HOIP-reconstituted
T4713 464-469 NN denotes cells
T4714 470-471 -LRB- denotes (
T4715 471-475 NN denotes Fig.
T4716 476-477 CD denotes 2
T4717 477-478 -RRB- denotes )
T4718 480-488 VB denotes Compared
T4719 489-491 TO denotes to
T4720 492-495 DT denotes the
T4721 496-504 JJ denotes parental
T4722 505-509 NN denotes cell
T4723 510-514 NN denotes line
T4724 514-515 -COMMA- denotes ,
T4725 516-519 DT denotes the
T4726 520-535 JJ denotes CD40-stimulated
T4727 536-548 NN denotes upregulation
T4728 549-551 IN denotes of
T4729 552-556 NN denotes CD80
T4730 557-560 VB denotes was
T4731 561-573 RB denotes dramatically
T4732 574-581 VB denotes reduced
T4733 582-584 IN denotes in
T4734 585-588 DT denotes all
T4735 589-603 JJ denotes HOIP-deficient
T4736 604-609 NN denotes cells
T4737 610-616 VB denotes tested
T4738 618-620 IN denotes In
T4739 621-629 NN denotes contrast
T4740 629-630 -COMMA- denotes ,
T4741 631-643 NN denotes upregulation
T4742 644-646 IN denotes of
T4743 647-651 NN denotes CD80
T4744 652-655 VB denotes was
T4745 656-664 VB denotes restored
T4746 665-667 IN denotes in
T4747 668-686 JJ denotes HOIP-reconstituted
T4748 687-692 NN denotes cells
T4749 692-693 -COMMA- denotes ,
T4750 694-704 VB denotes confirming
T4751 705-709 IN denotes that
T4752 710-713 DT denotes the
T4753 714-720 NN denotes defect
T4754 721-723 IN denotes in
T4755 724-728 NN denotes CD80
T4756 729-741 NN denotes upregulation
T4757 742-744 IN denotes in
T4758 745-748 DT denotes the
T4759 749-763 JJ denotes HOIP-deficient
T4760 764-769 NN denotes cells
T4761 770-773 VB denotes was
T4762 774-777 JJ denotes due
T4763 778-780 TO denotes to
T4764 781-784 DT denotes the
T4765 785-795 NN denotes disruption
T4766 796-798 IN denotes of
T4767 799-804 NN denotes Rnf31
T4768 1424-1428 NN denotes CD40
T4769 1429-1436 NN denotes signals
T4770 1437-1439 IN denotes in
T4771 1440-1441 NN denotes B
T4772 1442-1447 NN denotes cells
T4773 1448-1451 MD denotes can
T4774 1452-1456 RB denotes also
T4775 1457-1467 VB denotes contribute
T4776 1468-1470 TO denotes to
T4777 1471-1474 DT denotes the
T4778 1475-1485 NN denotes activation
T4779 1486-1488 IN denotes of
T4780 1489-1492 NN denotes DNA
T4781 1493-1506 NN denotes recombination
T4782 1507-1509 IN denotes in
T4783 1510-1513 DT denotes the
T4784 1514-1528 NN denotes immunoglobulin
T4785 1529-1534 JJ denotes heavy
T4786 1535-1540 NN denotes chain
T4787 1541-1546 NN denotes locus
T4788 1547-1548 -LRB- denotes [
T4789 1548-1550 CD denotes 11
T4790 1550-1551 -RRB- denotes ]
T4791 1551-1552 -COMMA- denotes ,
T4792 1553-1554 -LRB- denotes [
T4793 1554-1556 CD denotes 12
T4794 1556-1557 -RRB- denotes ]
T4795 1559-1563 DT denotes This
T4796 1564-1571 NN denotes process
T4797 1571-1572 -COMMA- denotes ,
T4798 1573-1578 VB denotes known
T4799 1579-1581 IN denotes as
T4800 1582-1596 NN denotes immunoglobulin
T4801 1597-1602 NN denotes class
T4802 1603-1612 NN denotes switching
T4803 1613-1614 -LRB- denotes (
T4804 1614-1616 CC denotes or
T4805 1617-1624 NN denotes isotype
T4806 1625-1634 NN denotes switching
T4807 1634-1635 -RRB- denotes )
T4808 1635-1636 -COMMA- denotes ,
T4809 1637-1643 VB denotes allows
T4810 1644-1645 NN denotes B
T4811 1646-1651 NN denotes cells
T4812 1651-1652 -COMMA- denotes ,
T4813 1653-1662 RB denotes initially
T4814 1663-1673 VB denotes expressing
T4815 1674-1677 NN denotes IgM
T4816 1677-1678 -COMMA- denotes ,
T4817 1679-1681 TO denotes to
T4818 1682-1688 VB denotes switch
T4819 1689-1691 TO denotes to
T4820 1692-1695 NN denotes IgA
T4821 1695-1696 -COMMA- denotes ,
T4822 1697-1700 NN denotes IgG
T4823 1700-1701 -COMMA- denotes ,
T4824 1702-1704 CC denotes or
T4825 1705-1708 NN denotes IgE
T4826 1709-1718 VB denotes depending
T4827 1719-1721 IN denotes on
T4828 1722-1725 DT denotes the
T4829 1726-1731 NN denotes class
T4830 1732-1734 IN denotes of
T4831 1735-1743 NN denotes antibody
T4832 1744-1748 RB denotes most
T4833 1749-1760 JJ denotes appropriate
T4834 1761-1764 IN denotes for
T4835 1765-1766 DT denotes a
T4836 1767-1777 JJ denotes particular
T4837 1778-1784 JJ denotes immune
T4838 1785-1793 NN denotes response
T4839 1795-1804 VB denotes Switching
T4840 1805-1807 TO denotes to
T4841 1808-1811 NN denotes IgE
T4842 1812-1815 MD denotes can
T4843 1816-1818 VB denotes be
T4844 1819-1826 VB denotes induced
T4845 1827-1829 IN denotes by
T4846 1830-1833 DT denotes the
T4847 1834-1845 NN denotes combination
T4848 1846-1848 IN denotes of
T4849 1849-1853 NN denotes IL-4
T4850 1854-1857 CC denotes and
T4851 1858-1862 NN denotes CD40
T4852 1863-1870 NN denotes signals
T4853 1872-1875 DT denotes The
T4854 1876-1880 NN denotes gene
T4855 1881-1894 NN denotes rearrangement
T4856 1895-1904 JJ denotes necessary
T4857 1905-1908 IN denotes for
T4858 1909-1912 NN denotes IgE
T4859 1913-1923 NN denotes production
T4860 1924-1926 VB denotes is
T4861 1927-1935 VB denotes preceded
T4862 1936-1938 IN denotes by
T4863 1939-1942 DT denotes the
T4864 1943-1953 NN denotes production
T4865 1954-1956 IN denotes of
T4866 1957-1967 JJ denotes non-coding
T4867 1968-1971 NN denotes RNA
T4868 1972-1983 NN denotes transcripts
T4869 1984-1988 IN denotes from
T4870 1989-1997 NN denotes germline
T4871 1998-2007 NN denotes sequences
T4872 2008-2010 IN denotes in
T4873 2011-2014 DT denotes the
T4874 2015-2018 NN denotes IgE
T4875 2019-2024 JJ denotes heavy
T4876 2025-2030 NN denotes chain
T4877 2031-2036 NN denotes locus
T4878 2037-2038 -LRB- denotes [
T4879 2038-2040 CD denotes 13
T4880 2040-2041 -RRB- denotes ]
T4881 2043-2045 TO denotes To
T4882 2046-2055 VB denotes determine
T4883 2056-2063 IN denotes whether
T4884 2064-2068 NN denotes HOIP
T4885 2069-2071 VB denotes is
T4886 2072-2080 VB denotes required
T4887 2081-2083 IN denotes in
T4888 2084-2087 DT denotes the
T4889 2088-2098 NN denotes initiation
T4890 2099-2101 IN denotes of
T4891 2102-2105 DT denotes the
T4892 2106-2111 NN denotes class
T4893 2112-2121 NN denotes switching
T4894 2122-2129 NN denotes process
T4895 2129-2130 -COMMA- denotes ,
T4896 2131-2134 DT denotes the
T4897 2135-2143 JJ denotes relevant
T4898 2144-2145 NN denotes B
T4899 2146-2150 NN denotes cell
T4900 2151-2156 NN denotes lines
T4901 2157-2161 VB denotes were
T4902 2162-2172 VB denotes stimulated
T4903 2173-2180 IN denotes through
T4904 2181-2185 NN denotes CD40
T4905 2186-2188 IN denotes in
T4906 2189-2192 DT denotes the
T4907 2193-2201 NN denotes presence
T4908 2202-2204 IN denotes of
T4909 2205-2209 NN denotes IL-4
T4910 2210-2213 CC denotes and
T4911 2214-2220 VB denotes tested
T4912 2221-2224 IN denotes for
T4913 2225-2235 NN denotes production
T4914 2236-2238 IN denotes of
T4915 2239-2247 NN denotes germline
T4916 2248-2255 NN denotes epsilon
T4917 2256-2257 -LRB- denotes (
T4918 2257-2260 NN denotes GLε
T4919 2260-2261 -RRB- denotes )
T4920 2262-2273 NN denotes transcripts
T4921 2274-2275 -LRB- denotes (
T4922 2275-2279 NN denotes Fig.
T4923 2280-2281 CD denotes 3
T4924 2281-2282 -RRB- denotes )
T4925 2284-2293 JJ denotes Anti-CD40
T4926 2294-2302 NN denotes antibody
T4927 2303-2314 NN denotes stimulation
T4928 2315-2320 RB denotes alone
T4929 2321-2323 CC denotes or
T4930 2324-2332 RB denotes together
T4931 2333-2337 IN denotes with
T4932 2338-2342 NN denotes IL-4
T4933 2343-2350 VB denotes induced
T4934 2351-2354 NN denotes GLε
T4935 2355-2368 NN denotes transcription
T4936 2369-2371 IN denotes in
T4937 2372-2380 JJ denotes parental
T4938 2381-2387 NN denotes A20.2J
T4939 2388-2393 NN denotes cells
T4940 2394-2396 IN denotes as
T4941 2397-2405 VB denotes expected
T4942 2407-2409 IN denotes In
T4943 2410-2418 NN denotes contrast
T4944 2418-2419 -COMMA- denotes ,
T4945 2420-2424 RB denotes only
T4946 2425-2428 JJ denotes low
T4947 2429-2435 NN denotes levels
T4948 2436-2438 IN denotes of
T4949 2439-2442 NN denotes GLε
T4950 2443-2453 NN denotes expression
T4951 2454-2458 VB denotes were
T4952 2459-2467 VB denotes detected
T4953 2468-2470 IN denotes in
T4954 2471-2485 JJ denotes HOIP-deficient
T4955 2486-2491 NN denotes cells
T4956 2492-2502 VB denotes stimulated
T4957 2503-2507 IN denotes with
T4958 2508-2514 CC denotes either
T4959 2515-2524 JJ denotes anti-CD40
T4960 2525-2533 NN denotes antibody
T4961 2534-2539 RB denotes alone
T4962 2540-2542 CC denotes or
T4963 2543-2552 NN denotes anti-CD40
T4964 2553-2556 CC denotes and
T4965 2557-2561 NN denotes IL-4
T4966 2563-2569 JJ denotes Normal
T4967 2570-2576 NN denotes levels
T4968 2577-2579 IN denotes of
T4969 2580-2583 NN denotes GLε
T4970 2584-2594 NN denotes expression
T4971 2595-2599 VB denotes were
T4972 2600-2607 VB denotes induced
T4973 2608-2610 IN denotes in
T4974 2611-2629 JJ denotes HOIP-reconstituted
T4975 2630-2635 NN denotes cells
T4976 2636-2646 VB denotes stimulated
T4977 2647-2651 IN denotes with
T4978 2652-2661 JJ denotes anti-CD40
T4979 2662-2670 NN denotes antibody
T4980 2671-2676 RB denotes alone
T4981 2677-2679 CC denotes or
T4982 2680-2688 RB denotes together
T4983 2689-2693 IN denotes with
T4984 2694-2698 NN denotes IL-4
T4985 2700-2712 RB denotes Collectively
T4986 2712-2713 -COMMA- denotes ,
T4987 2714-2719 DT denotes these
T4988 2720-2724 NN denotes data
T4989 2725-2736 VB denotes demonstrate
T4990 2737-2741 IN denotes that
T4991 2742-2746 NN denotes HOIP
T4992 2747-2750 VB denotes has
T4993 2751-2752 DT denotes a
T4994 2753-2761 JJ denotes critical
T4995 2762-2766 NN denotes role
T4996 2767-2769 IN denotes in
T4997 2770-2778 JJ denotes cellular
T4998 2779-2788 NN denotes responses
T4999 2789-2791 TO denotes to
T5000 2792-2796 NN denotes CD40
T5001 2797-2806 NN denotes signaling
T15490 850-863 JJ denotes CD40-mediated
T15491 864-868 NN denotes CD80
T15492 869-881 NN denotes upregulation
T15493 882-884 VB denotes is
T15494 885-894 JJ denotes defective
T15495 895-897 IN denotes in
T15496 898-912 JJ denotes HOIP-deficient
T15497 913-918 NN denotes cells
T15498 920-925 NN denotes Cells
T15499 926-930 VB denotes were
T15500 931-940 VB denotes incubated
T15501 941-944 IN denotes for
T15502 945-947 CD denotes 72
T15503 948-951 NN denotes hrs
T15504 952-956 IN denotes with
T15505 957-959 DT denotes an
T15506 960-967 NN denotes isotype
T15507 968-975 NN denotes control
T15508 976-984 NN denotes antibody
T15509 985-986 -LRB- denotes (
T15510 986-990 JJ denotes left
T15511 990-991 -RRB- denotes )
T15512 992-994 CC denotes or
T15513 995-1004 JJ denotes anti-CD40
T15514 1005-1013 NN denotes antibody
T15515 1014-1015 -LRB- denotes (
T15516 1015-1020 NN denotes right
T15517 1020-1021 -RRB- denotes )
T15518 1022-1025 CC denotes and
T15519 1026-1030 RB denotes then
T15520 1031-1038 VB denotes stained
T15521 1039-1042 IN denotes for
T15522 1043-1053 NN denotes expression
T15523 1054-1056 IN denotes of
T15524 1057-1061 NN denotes CD80
T15525 1062-1063 -LRB- denotes (
T15526 1063-1069 VB denotes filled
T15527 1070-1078 NN denotes profiles
T15528 1079-1087 VB denotes indicate
T15529 1088-1096 NN denotes staining
T15530 1097-1101 IN denotes with
T15531 1102-1111 JJ denotes anti-CD80
T15532 1112-1120 NN denotes antibody
T15533 1120-1121 -COLON- denotes ;
T15534 1122-1126 JJ denotes open
T15535 1127-1135 NN denotes profiles
T15536 1136-1139 VB denotes are
T15537 1140-1148 VB denotes staining
T15538 1149-1153 IN denotes with
T15539 1154-1156 DT denotes an
T15540 1157-1164 NN denotes isotype
T15541 1165-1172 NN denotes control
T15542 1173-1181 NN denotes antibody
T15543 1181-1182 -RRB- denotes )
T15544 1184-1196 NN denotes Transduction
T15545 1197-1199 IN denotes of
T15546 1200-1204 CC denotes both
T15547 1205-1219 JJ denotes HOIP-deficient
T15548 1220-1221 -LRB- denotes (
T15549 1221-1228 JJ denotes HOIP-/-
T15550 1228-1229 -RRB- denotes )
T15551 1230-1236 NN denotes clones
T15552 1237-1241 IN denotes with
T15553 1242-1243 DT denotes a
T15554 1244-1254 NN denotes retrovirus
T15555 1255-1263 VB denotes encoding
T15556 1264-1273 NN denotes FLAG-HOIP
T15557 1274-1282 VB denotes reversed
T15558 1283-1292 JJ denotes defective
T15559 1293-1297 NN denotes CD80
T15560 1298-1310 NN denotes upregulation
T15561 1310-1311 -COMMA- denotes ,
T15562 1312-1317 IN denotes while
T15563 1318-1330 NN denotes transduction
T15564 1331-1335 IN denotes with
T15565 1336-1338 DT denotes an
T15566 1339-1344 JJ denotes empty
T15567 1345-1351 NN denotes vector
T15568 1352-1353 -LRB- denotes (
T15569 1353-1357 NN denotes pMIP
T15570 1357-1358 -RRB- denotes )
T15571 1359-1362 VB denotes did
T15572 1363-1366 RB denotes not
T15573 1368-1375 JJ denotes Similar
T15574 1376-1383 NN denotes results
T15575 1384-1388 VB denotes were
T15576 1389-1397 VB denotes obtained
T15577 1398-1400 IN denotes in
T15578 1401-1402 DT denotes a
T15579 1403-1409 JJ denotes second
T15580 1410-1420 NN denotes experiment
T15889 2852-2855 NN denotes GLε
T15890 2856-2869 NN denotes transcription
T15891 2870-2872 VB denotes is
T15892 2873-2882 JJ denotes defective
T15893 2883-2885 IN denotes in
T15894 2886-2901 JJ denotes CD40-stimulated
T15895 2902-2916 JJ denotes HOIP-deficient
T15896 2917-2922 NN denotes cells
T15897 2924-2930 NN denotes A20.2J
T15898 2931-2934 CC denotes and
T15899 2935-2949 JJ denotes HOIP-deficient
T15900 2950-2955 NN denotes cells
T15901 2956-2966 VB denotes transduced
T15902 2967-2971 IN denotes with
T15903 2972-2974 DT denotes an
T15904 2975-2980 JJ denotes empty
T15905 2981-2991 JJ denotes retroviral
T15906 2992-2998 NN denotes vector
T15907 2999-3000 -LRB- denotes (
T15908 3000-3006 NN denotes A20.2J
T15909 3007-3008 SYM denotes +
T15910 3009-3013 NN denotes pMIP
T15911 3014-3017 CC denotes and
T15912 3018-3025 JJ denotes HOIP-/-
T15913 3026-3027 SYM denotes +
T15914 3028-3032 NN denotes pMIP
T15915 3032-3033 -COMMA- denotes ,
T15916 3034-3046 RB denotes respectively
T15917 3046-3047 -RRB- denotes )
T15918 3047-3048 -COMMA- denotes ,
T15919 3049-3051 CC denotes or
T15920 3052-3066 JJ denotes HOIP-deficient
T15921 3067-3072 NN denotes cells
T15922 3073-3083 VB denotes transduced
T15923 3084-3088 IN denotes with
T15924 3089-3090 DT denotes a
T15925 3091-3104 JJ denotes HOIP-encoding
T15926 3105-3115 NN denotes retrovirus
T15927 3116-3117 -LRB- denotes (
T15928 3117-3124 JJ denotes HOIP-/-
T15929 3125-3126 SYM denotes +
T15930 3127-3131 NN denotes HOIP
T15931 3131-3132 -RRB- denotes )
T15932 3133-3137 VB denotes were
T15933 3138-3146 VB denotes cultured
T15934 3147-3156 RB denotes overnight
T15935 3157-3161 IN denotes with
T15936 3162-3171 JJ denotes agonistic
T15937 3172-3181 NN denotes anti-CD40
T15938 3182-3184 CC denotes or
T15939 3185-3187 DT denotes an
T15940 3188-3195 NN denotes isotype
T15941 3196-3203 NN denotes control
T15942 3204-3212 NN denotes antibody
T15943 3213-3214 -LRB- denotes (
T15944 3214-3217 NN denotes iso
T15945 3217-3218 -RRB- denotes )
T15946 3218-3219 -COMMA- denotes ,
T15947 3220-3224 IN denotes with
T15948 3225-3227 CC denotes or
T15949 3228-3235 IN denotes without
T15950 3236-3240 NN denotes IL-4
T15951 3242-3245 NN denotes RNA
T15952 3246-3249 VB denotes was
T15953 3250-3258 VB denotes isolated
T15954 3259-3263 IN denotes from
T15955 3264-3267 DT denotes the
T15956 3268-3273 NN denotes cells
T15957 3273-3274 -COMMA- denotes ,
T15958 3275-3294 JJ denotes reverse-transcribed
T15959 3294-3295 -COMMA- denotes ,
T15960 3296-3299 CC denotes and
T15961 3300-3304 RB denotes then
T15962 3305-3314 VB denotes subjected
T15963 3315-3317 TO denotes to
T15964 3318-3330 JJ denotes quantitative
T15965 3331-3334 NN denotes PCR
T15966 3335-3337 TO denotes to
T15967 3338-3347 VB denotes determine
T15968 3348-3354 NN denotes levels
T15969 3355-3357 IN denotes of
T15970 3358-3361 NN denotes GLε
T15971 3362-3373 NN denotes transcripts
T15972 3375-3382 NN denotes Results
T15973 3383-3387 VB denotes were
T15974 3388-3398 VB denotes normalized
T15975 3399-3401 TO denotes to
T15976 3402-3405 DT denotes the
T15977 3406-3412 NN denotes levels
T15978 3413-3415 IN denotes of
T15979 3416-3421 NN denotes Hprt1
T15980 3422-3433 NN denotes transcripts
T15981 3434-3436 IN denotes in
T15982 3437-3441 DT denotes each
T15983 3442-3448 NN denotes sample
T15984 3450-3457 NN denotes Symbols
T15985 3458-3466 VB denotes indicate
T15986 3467-3470 DT denotes the
T15987 3471-3477 NN denotes values
T15988 3478-3482 IN denotes from
T15989 3483-3492 NN denotes duplicate
T15990 3493-3501 NN denotes cultures
T15991 3502-3503 -LRB- denotes (
T15992 3503-3504 DT denotes a
T15993 3505-3509 NN denotes line
T15994 3510-3519 VB denotes indicates
T15995 3520-3523 DT denotes the
T15996 3524-3528 NN denotes mean
T15997 3529-3531 IN denotes of
T15998 3532-3535 DT denotes the
T15999 3536-3539 CD denotes two
T16000 3540-3546 NN denotes values
T16001 3546-3547 -RRB- denotes )
T16002 3549-3556 JJ denotes Similar
T16003 3557-3564 NN denotes results
T16004 3565-3569 VB denotes were
T16005 3570-3578 VB denotes obtained
T16006 3579-3581 IN denotes in
T16007 3582-3583 DT denotes a
T16008 3584-3590 JJ denotes second
T16009 3591-3601 NN denotes experiment
T16010 3602-3605 CC denotes and
T16011 3606-3608 IN denotes in
T16012 3609-3611 DT denotes an
T16013 3612-3622 JJ denotes additional
T16014 3623-3633 NN denotes experiment
T16015 3634-3638 IN denotes with
T16016 3639-3640 DT denotes a
T16017 3641-3647 JJ denotes second
T16018 3648-3662 JJ denotes HOIP-deficient
T16019 3663-3668 NN denotes clone
R3629 T4639 T4640 arg1Of HOIP,is
R3630 T4639 T4641 arg2Of HOIP,required
R3631 T4641 T4640 arg2Of required,is
R3632 T4641 T4642 arg1Of required,for
R3633 T4645 T4643 arg1Of upregulation,CD40-mediated
R3634 T4645 T4644 arg1Of upregulation,CD80
R3635 T4645 T4646 arg1Of upregulation,and
R3636 T4646 T4642 arg2Of and,for
R3637 T4647 T4646 arg2Of activation,and
R3638 T4647 T4648 arg1Of activation,of
R3639 T4651 T4648 arg2Of transcription,of
R3640 T4651 T4649 arg1Of transcription,germline
R3641 T4651 T4650 arg1Of transcription,epsilon
R3642 T4652 T4653 arg1Of Engagement,of
R3643 T4652 T4655 arg1Of Engagement,on
R3644 T4652 T4658 arg1Of Engagement,upregulates
R3645 T4654 T4653 arg2Of CD40,of
R3646 T4657 T4655 arg2Of cells,on
R3647 T4657 T4656 arg1Of cells,B
R3648 T4659 T4658 arg2Of expression,upregulates
R3649 T4659 T4660 arg1Of expression,of
R3650 T4661 T4660 arg2Of CD80,of
R3651 T4661 T4662 arg1Of CD80,[
R3652 T4661 T4665 arg1Of CD80,","
R3653 T4663 T4662 arg2Of 10,[
R3654 T4664 T4662 arg3Of ],[
R3655 T4669 T4665 arg2Of protein,","
R3656 T4669 T4666 arg1Of protein,a
R3657 T4669 T4667 arg1Of protein,cell
R3658 T4669 T4668 arg1Of protein,surface
R3659 T4669 T4670 arg1Of protein,that
R3660 T4669 T4671 arg1Of protein,promotes
R3661 T4672 T4673 arg1Of activation,of
R3662 T4672 T4680 arg1Of activation,and
R3663 T4675 T4673 arg2Of cells,of
R3664 T4675 T4674 arg1Of cells,T
R3665 T4675 T4676 arg1Of cells,interacting
R3666 T4676 T4677 arg1Of interacting,with
R3667 T4679 T4677 arg2Of cells,with
R3668 T4679 T4678 arg1Of cells,B
R3669 T4680 T4671 arg2Of and,promotes
R3670 T4682 T4680 arg2Of APC,and
R3671 T4682 T4681 arg1Of APC,other
R3672 T4684 T4683 arg1Of begin,To
R3673 T4685 T4684 arg2Of evaluating,begin
R3674 T4687 T4685 arg2Of contributions,evaluating
R3675 T4687 T4686 arg1Of contributions,potential
R3676 T4687 T4688 arg1Of contributions,of
R3677 T4689 T4688 arg2Of HOIP,of
R3678 T4689 T4690 arg1Of HOIP,to
R3679 T4692 T4690 arg2Of signaling,to
R3680 T4692 T4691 arg1Of signaling,CD40
R3681 T4694 T4684 arg1Of we,begin
R3682 T4694 T4685 arg1Of we,evaluating
R3683 T4694 T4695 arg1Of we,assayed
R3684 T4695 T4683 modOf assayed,To
R3685 T4695 T4693 arg1Of assayed,","
R3686 T4697 T4695 arg2Of upregulation,assayed
R3687 T4697 T4696 arg1Of upregulation,the
R3688 T4697 T4698 arg1Of upregulation,of
R3689 T4699 T4698 arg2Of CD80,of
R3690 T4699 T4700 arg2Of CD80,induced
R3691 T4702 T4700 arg1Of engagement,induced
R3692 T4702 T4701 arg2Of engagement,by
R3693 T4702 T4703 arg1Of engagement,of
R3694 T4704 T4703 arg2Of CD40,of
R3695 T4704 T4705 arg1Of CD40,on
R3696 T4707 T4708 arg1Of A20.2J,","
R3697 T4709 T4711 arg1Of HOIP-deficient,and
R3698 T4711 T4708 arg2Of and,","
R3699 T4711 T4710 arg1Of and,","
R3700 T4712 T4711 arg2Of HOIP-reconstituted,and
R3701 T4713 T4705 arg2Of cells,on
R3702 T4713 T4706 arg1Of cells,parental
R3703 T4713 T4707 arg1Of cells,A20.2J
R3704 T4713 T4709 arg1Of cells,HOIP-deficient
R3705 T4713 T4712 arg1Of cells,HOIP-reconstituted
R3706 T4713 T4714 arg1Of cells,(
R3707 T4715 T4714 arg2Of Fig.,(
R3708 T4715 T4716 arg1Of Fig.,2
R3709 T4717 T4714 arg3Of ),(
R3710 T4719 T4718 arg2Of to,Compared
R3711 T4723 T4719 arg2Of line,to
R3712 T4723 T4720 arg1Of line,the
R3713 T4723 T4721 arg1Of line,parental
R3714 T4723 T4722 arg1Of line,cell
R3715 T4727 T4725 arg1Of upregulation,the
R3716 T4727 T4726 arg1Of upregulation,CD40-stimulated
R3717 T4727 T4728 arg1Of upregulation,of
R3718 T4727 T4730 arg1Of upregulation,was
R3719 T4727 T4732 arg2Of upregulation,reduced
R3720 T4729 T4728 arg2Of CD80,of
R3721 T4732 T4718 arg1Of reduced,Compared
R3722 T4732 T4724 arg1Of reduced,","
R3723 T4732 T4730 arg2Of reduced,was
R3724 T4732 T4731 arg1Of reduced,dramatically
R3725 T4732 T4733 arg1Of reduced,in
R3726 T4736 T4733 arg2Of cells,in
R3727 T4736 T4734 arg1Of cells,all
R3728 T4736 T4735 arg1Of cells,HOIP-deficient
R3729 T4736 T4737 arg2Of cells,tested
R3730 T4739 T4738 arg2Of contrast,In
R3731 T4741 T4742 arg1Of upregulation,of
R3732 T4741 T4744 arg1Of upregulation,was
R3733 T4741 T4745 arg2Of upregulation,restored
R3734 T4743 T4742 arg2Of CD80,of
R3735 T4745 T4738 arg1Of restored,In
R3736 T4745 T4740 arg1Of restored,","
R3737 T4745 T4744 arg2Of restored,was
R3738 T4745 T4746 arg1Of restored,in
R3739 T4745 T4749 arg1Of restored,","
R3740 T4745 T4750 modOf restored,confirming
R3741 T4748 T4746 arg2Of cells,in
R3742 T4748 T4747 arg1Of cells,HOIP-reconstituted
R3743 T4753 T4752 arg1Of defect,the
R3744 T4753 T4754 arg1Of defect,in
R3745 T4753 T4757 arg1Of defect,in
R3746 T4753 T4761 arg1Of defect,was
R3747 T4753 T4762 arg1Of defect,due
R3748 T4756 T4754 arg2Of upregulation,in
R3749 T4756 T4755 arg1Of upregulation,CD80
R3750 T4760 T4757 arg2Of cells,in
R3751 T4760 T4758 arg1Of cells,the
R3752 T4760 T4759 arg1Of cells,HOIP-deficient
R3753 T4761 T4750 arg2Of was,confirming
R3754 T4761 T4751 arg1Of was,that
R3755 T4762 T4761 arg2Of due,was
R3756 T4762 T4763 arg1Of due,to
R3757 T4765 T4763 arg2Of disruption,to
R3758 T4765 T4764 arg1Of disruption,the
R3759 T4765 T4766 arg1Of disruption,of
R3760 T4767 T4766 arg2Of Rnf31,of
R3761 T4769 T4768 arg1Of signals,CD40
R3762 T4769 T4770 arg1Of signals,in
R3763 T4769 T4773 arg1Of signals,can
R3764 T4769 T4775 arg1Of signals,contribute
R3765 T4772 T4770 arg2Of cells,in
R3766 T4772 T4771 arg1Of cells,B
R3767 T4775 T4773 arg2Of contribute,can
R3768 T4775 T4774 arg1Of contribute,also
R3769 T4775 T4776 arg1Of contribute,to
R3770 T4775 T4791 arg1Of contribute,","
R3771 T4775 T4792 arg1Of contribute,[
R3772 T4778 T4776 arg2Of activation,to
R3773 T4778 T4777 arg1Of activation,the
R3774 T4778 T4779 arg1Of activation,of
R3775 T4778 T4782 arg1Of activation,in
R3776 T4781 T4779 arg2Of recombination,of
R3777 T4781 T4780 arg1Of recombination,DNA
R3778 T4787 T4782 arg2Of locus,in
R3779 T4787 T4783 arg1Of locus,the
R3780 T4787 T4784 arg1Of locus,immunoglobulin
R3781 T4787 T4785 arg1Of locus,heavy
R3782 T4787 T4786 arg1Of locus,chain
R3783 T4787 T4788 arg1Of locus,[
R3784 T4789 T4788 arg2Of 11,[
R3785 T4790 T4788 arg3Of ],[
R3786 T4793 T4792 arg2Of 12,[
R3787 T4794 T4792 arg3Of ],[
R3788 T4796 T4795 arg1Of process,This
R3789 T4796 T4797 arg1Of process,","
R3790 T4796 T4798 arg2Of process,known
R3791 T4796 T4809 arg1Of process,allows
R3792 T4796 T4814 arg1Of process,expressing
R3793 T4798 T4799 arg1Of known,as
R3794 T4802 T4799 arg2Of switching,as
R3795 T4802 T4800 arg1Of switching,immunoglobulin
R3796 T4802 T4801 arg1Of switching,class
R3797 T4802 T4803 arg1Of switching,(
R3798 T4806 T4803 arg2Of switching,(
R3799 T4806 T4804 arg1Of switching,or
R3800 T4806 T4805 arg1Of switching,isotype
R3801 T4807 T4803 arg3Of ),(
R3802 T4809 T4808 arg1Of allows,","
R3803 T4809 T4812 arg1Of allows,","
R3804 T4809 T4814 modOf allows,expressing
R3805 T4811 T4809 arg2Of cells,allows
R3806 T4811 T4810 arg1Of cells,B
R3807 T4814 T4813 arg1Of expressing,initially
R3808 T4814 T4817 modOf expressing,to
R3809 T4815 T4814 arg2Of IgM,expressing
R3810 T4815 T4833 arg1Of IgM,appropriate
R3811 T4818 T4816 arg1Of switch,","
R3812 T4818 T4817 arg1Of switch,to
R3813 T4818 T4819 arg1Of switch,to
R3814 T4818 T4826 arg1Of switch,depending
R3815 T4820 T4821 arg1Of IgA,","
R3816 T4821 T4824 arg1Of ",",or
R3817 T4822 T4821 arg2Of IgG,","
R3818 T4824 T4819 arg2Of or,to
R3819 T4824 T4823 arg1Of or,","
R3820 T4825 T4824 arg2Of IgE,or
R3821 T4827 T4826 arg2Of on,depending
R3822 T4829 T4827 arg2Of class,on
R3823 T4829 T4828 arg1Of class,the
R3824 T4829 T4830 arg1Of class,of
R3825 T4831 T4830 arg2Of antibody,of
R3826 T4833 T4814 arg3Of appropriate,expressing
R3827 T4833 T4832 arg1Of appropriate,most
R3828 T4833 T4834 arg1Of appropriate,for
R3829 T4838 T4834 arg2Of response,for
R3830 T4838 T4835 arg1Of response,a
R3831 T4838 T4836 arg1Of response,particular
R3832 T4838 T4837 arg1Of response,immune
R3833 T4839 T4840 arg1Of Switching,to
R3834 T4839 T4842 arg1Of Switching,can
R3835 T4839 T4843 arg1Of Switching,be
R3836 T4839 T4844 arg2Of Switching,induced
R3837 T4841 T4840 arg2Of IgE,to
R3838 T4844 T4842 arg2Of induced,can
R3839 T4844 T4843 arg2Of induced,be
R3840 T4847 T4844 arg1Of combination,induced
R3841 T4847 T4845 arg2Of combination,by
R3842 T4847 T4846 arg1Of combination,the
R3843 T4847 T4848 arg1Of combination,of
R3844 T4849 T4850 arg1Of IL-4,and
R3845 T4851 T4850 arg2Of CD40,and
R3846 T4852 T4848 arg2Of signals,of
R3847 T4852 T4849 arg1Of signals,IL-4
R3848 T4852 T4851 arg1Of signals,CD40
R3849 T4855 T4853 arg1Of rearrangement,The
R3850 T4855 T4854 arg1Of rearrangement,gene
R3851 T4855 T4856 arg1Of rearrangement,necessary
R3852 T4855 T4860 arg1Of rearrangement,is
R3853 T4855 T4861 arg2Of rearrangement,preceded
R3854 T4856 T4857 arg1Of necessary,for
R3855 T4859 T4857 arg2Of production,for
R3856 T4859 T4858 arg1Of production,IgE
R3857 T4861 T4860 arg2Of preceded,is
R3858 T4864 T4861 arg1Of production,preceded
R3859 T4864 T4862 arg2Of production,by
R3860 T4864 T4863 arg1Of production,the
R3861 T4864 T4865 arg1Of production,of
R3862 T4868 T4865 arg2Of transcripts,of
R3863 T4868 T4866 arg1Of transcripts,non-coding
R3864 T4868 T4867 arg1Of transcripts,RNA
R3865 T4868 T4869 arg1Of transcripts,from
R3866 T4871 T4869 arg2Of sequences,from
R3867 T4871 T4870 arg1Of sequences,germline
R3868 T4871 T4872 arg1Of sequences,in
R3869 T4877 T4872 arg2Of locus,in
R3870 T4877 T4873 arg1Of locus,the
R3871 T4877 T4874 arg1Of locus,IgE
R3872 T4877 T4875 arg1Of locus,heavy
R3873 T4877 T4876 arg1Of locus,chain
R3874 T4877 T4878 arg1Of locus,[
R3875 T4879 T4878 arg2Of 13,[
R3876 T4880 T4878 arg3Of ],[
R3877 T4882 T4881 arg1Of determine,To
R3878 T4884 T4885 arg1Of HOIP,is
R3879 T4884 T4886 arg2Of HOIP,required
R3880 T4886 T4882 arg2Of required,determine
R3881 T4886 T4883 arg1Of required,whether
R3882 T4886 T4885 arg2Of required,is
R3883 T4886 T4887 arg1Of required,in
R3884 T4889 T4887 arg2Of initiation,in
R3885 T4889 T4888 arg1Of initiation,the
R3886 T4889 T4890 arg1Of initiation,of
R3887 T4894 T4890 arg2Of process,of
R3888 T4894 T4891 arg1Of process,the
R3889 T4894 T4892 arg1Of process,class
R3890 T4894 T4893 arg1Of process,switching
R3891 T4900 T4896 arg1Of lines,the
R3892 T4900 T4897 arg1Of lines,relevant
R3893 T4900 T4898 arg1Of lines,B
R3894 T4900 T4899 arg1Of lines,cell
R3895 T4900 T4901 arg1Of lines,were
R3896 T4900 T4902 arg2Of lines,stimulated
R3897 T4900 T4911 arg2Of lines,tested
R3898 T4902 T4903 arg1Of stimulated,through
R3899 T4902 T4905 arg1Of stimulated,in
R3900 T4902 T4910 arg1Of stimulated,and
R3901 T4904 T4903 arg2Of CD40,through
R3902 T4907 T4905 arg2Of presence,in
R3903 T4907 T4906 arg1Of presence,the
R3904 T4907 T4908 arg1Of presence,of
R3905 T4909 T4908 arg2Of IL-4,of
R3906 T4910 T4881 modOf and,To
R3907 T4910 T4895 arg1Of and,","
R3908 T4910 T4901 arg2Of and,were
R3909 T4911 T4910 arg2Of tested,and
R3910 T4911 T4912 arg1Of tested,for
R3911 T4913 T4912 arg2Of production,for
R3912 T4913 T4914 arg1Of production,of
R3913 T4916 T4915 arg1Of epsilon,germline
R3914 T4916 T4917 arg1Of epsilon,(
R3915 T4918 T4917 arg2Of GLε,(
R3916 T4919 T4917 arg3Of ),(
R3917 T4920 T4914 arg2Of transcripts,of
R3918 T4920 T4916 arg1Of transcripts,epsilon
R3919 T4920 T4921 arg1Of transcripts,(
R3920 T4922 T4921 arg2Of Fig.,(
R3921 T4922 T4923 arg1Of Fig.,3
R3922 T4924 T4921 arg3Of ),(
R3923 T4927 T4925 arg1Of stimulation,Anti-CD40
R3924 T4927 T4926 arg1Of stimulation,antibody
R3925 T4927 T4928 arg1Of stimulation,alone
R3926 T4927 T4930 arg1Of stimulation,together
R3927 T4927 T4933 arg1Of stimulation,induced
R3928 T4928 T4929 arg1Of alone,or
R3929 T4929 T4931 arg1Of or,with
R3930 T4930 T4929 arg2Of together,or
R3931 T4932 T4931 arg2Of IL-4,with
R3932 T4935 T4933 arg2Of transcription,induced
R3933 T4935 T4934 arg1Of transcription,GLε
R3934 T4935 T4936 arg1Of transcription,in
R3935 T4939 T4936 arg2Of cells,in
R3936 T4939 T4937 arg1Of cells,parental
R3937 T4939 T4938 arg1Of cells,A20.2J
R3938 T4940 T4933 arg3Of as,induced
R3939 T4941 T4940 arg2Of expected,as
R3940 T4943 T4942 arg2Of contrast,In
R3941 T4947 T4945 arg1Of levels,only
R3942 T4947 T4946 arg1Of levels,low
R3943 T4947 T4948 arg1Of levels,of
R3944 T4947 T4951 arg1Of levels,were
R3945 T4947 T4952 arg2Of levels,detected
R3946 T4950 T4948 arg2Of expression,of
R3947 T4950 T4949 arg1Of expression,GLε
R3948 T4952 T4942 arg1Of detected,In
R3949 T4952 T4944 arg1Of detected,","
R3950 T4952 T4951 arg2Of detected,were
R3951 T4952 T4953 arg1Of detected,in
R3952 T4955 T4953 arg2Of cells,in
R3953 T4955 T4954 arg1Of cells,HOIP-deficient
R3954 T4955 T4956 arg2Of cells,stimulated
R3955 T4956 T4957 arg1Of stimulated,with
R3956 T4960 T4959 arg1Of antibody,anti-CD40
R3957 T4960 T4961 arg1Of antibody,alone
R3958 T4960 T4962 arg1Of antibody,or
R3959 T4962 T4957 arg2Of or,with
R3960 T4962 T4958 arg1Of or,either
R3961 T4963 T4964 arg1Of anti-CD40,and
R3962 T4964 T4962 arg2Of and,or
R3963 T4965 T4964 arg2Of IL-4,and
R3964 T4967 T4966 arg1Of levels,Normal
R3965 T4967 T4968 arg1Of levels,of
R3966 T4967 T4971 arg1Of levels,were
R3967 T4967 T4972 arg2Of levels,induced
R3968 T4970 T4968 arg2Of expression,of
R3969 T4970 T4969 arg1Of expression,GLε
R3970 T4972 T4971 arg2Of induced,were
R3971 T4972 T4973 arg1Of induced,in
R3972 T4975 T4973 arg2Of cells,in
R3973 T4975 T4974 arg1Of cells,HOIP-reconstituted
R3974 T4975 T4976 arg2Of cells,stimulated
R3975 T4976 T4977 arg1Of stimulated,with
R3976 T4979 T4977 arg2Of antibody,with
R3977 T4979 T4978 arg1Of antibody,anti-CD40
R3978 T4979 T4980 arg1Of antibody,alone
R3979 T4979 T4982 arg1Of antibody,together
R3980 T4980 T4981 arg1Of alone,or
R3981 T4981 T4983 arg1Of or,with
R3982 T4982 T4981 arg2Of together,or
R3983 T4984 T4983 arg2Of IL-4,with
R3984 T4988 T4987 arg1Of data,these
R3985 T4988 T4989 arg1Of data,demonstrate
R3986 T4989 T4985 arg1Of demonstrate,Collectively
R3987 T4989 T4986 arg1Of demonstrate,","
R3988 T4991 T4992 arg1Of HOIP,has
R3989 T4992 T4989 arg2Of has,demonstrate
R3990 T4992 T4990 arg1Of has,that
R3991 T4992 T4996 arg1Of has,in
R3992 T4995 T4992 arg2Of role,has
R3993 T4995 T4993 arg1Of role,a
R3994 T4995 T4994 arg1Of role,critical
R3995 T4998 T4996 arg2Of responses,in
R3996 T4998 T4997 arg1Of responses,cellular
R3997 T4998 T4999 arg1Of responses,to
R3998 T5001 T4999 arg2Of signaling,to
R3999 T5001 T5000 arg1Of signaling,CD40
R12278 T15492 T15490 arg1Of upregulation,CD40-mediated
R12279 T15492 T15491 arg1Of upregulation,CD80
R12280 T15492 T15493 arg1Of upregulation,is
R12281 T15492 T15494 arg1Of upregulation,defective
R12282 T15493 T15495 arg1Of is,in
R12283 T15494 T15493 arg2Of defective,is
R12284 T15497 T15495 arg2Of cells,in
R12285 T15497 T15496 arg1Of cells,HOIP-deficient
R12286 T15498 T15499 arg1Of Cells,were
R12287 T15498 T15500 arg2Of Cells,incubated
R12288 T15498 T15520 arg2Of Cells,stained
R12289 T15500 T15501 arg1Of incubated,for
R12290 T15500 T15518 arg1Of incubated,and
R12291 T15503 T15501 arg2Of hrs,for
R12292 T15503 T15502 arg1Of hrs,72
R12293 T15503 T15504 arg1Of hrs,with
R12294 T15508 T15506 arg1Of antibody,isotype
R12295 T15508 T15507 arg1Of antibody,control
R12296 T15508 T15509 arg1Of antibody,(
R12297 T15508 T15512 arg1Of antibody,or
R12298 T15510 T15509 arg2Of left,(
R12299 T15511 T15509 arg3Of ),(
R12300 T15512 T15504 arg2Of or,with
R12301 T15512 T15505 arg1Of or,an
R12302 T15514 T15512 arg2Of antibody,or
R12303 T15514 T15513 arg1Of antibody,anti-CD40
R12304 T15514 T15515 arg1Of antibody,(
R12305 T15516 T15515 arg2Of right,(
R12306 T15517 T15515 arg3Of ),(
R12307 T15518 T15499 arg2Of and,were
R12308 T15520 T15518 arg2Of stained,and
R12309 T15520 T15519 arg1Of stained,then
R12310 T15520 T15521 arg1Of stained,for
R12311 T15522 T15521 arg2Of expression,for
R12312 T15522 T15523 arg1Of expression,of
R12313 T15524 T15523 arg2Of CD80,of
R12314 T15524 T15525 arg1Of CD80,(
R12315 T15527 T15526 arg2Of profiles,filled
R12316 T15527 T15528 arg1Of profiles,indicate
R12317 T15528 T15525 arg2Of indicate,(
R12318 T15528 T15530 arg1Of indicate,with
R12319 T15528 T15533 arg1Of indicate,;
R12320 T15529 T15528 arg2Of staining,indicate
R12321 T15532 T15530 arg2Of antibody,with
R12322 T15532 T15531 arg1Of antibody,anti-CD80
R12323 T15535 T15534 arg1Of profiles,open
R12324 T15535 T15536 arg1Of profiles,are
R12325 T15535 T15537 arg1Of profiles,staining
R12326 T15537 T15533 arg2Of staining,;
R12327 T15537 T15536 arg2Of staining,are
R12328 T15537 T15538 arg1Of staining,with
R12329 T15542 T15538 arg2Of antibody,with
R12330 T15542 T15539 arg1Of antibody,an
R12331 T15542 T15540 arg1Of antibody,isotype
R12332 T15542 T15541 arg1Of antibody,control
R12333 T15543 T15525 arg3Of ),(
R12334 T15544 T15545 arg1Of Transduction,of
R12335 T15544 T15557 arg1Of Transduction,reversed
R12336 T15547 T15548 arg1Of HOIP-deficient,(
R12337 T15549 T15548 arg2Of HOIP-/-,(
R12338 T15550 T15548 arg3Of ),(
R12339 T15551 T15545 arg2Of clones,of
R12340 T15551 T15546 arg1Of clones,both
R12341 T15551 T15547 arg1Of clones,HOIP-deficient
R12342 T15551 T15552 arg1Of clones,with
R12343 T15554 T15552 arg2Of retrovirus,with
R12344 T15554 T15553 arg1Of retrovirus,a
R12345 T15554 T15555 arg1Of retrovirus,encoding
R12346 T15556 T15555 arg2Of FLAG-HOIP,encoding
R12347 T15557 T15561 arg1Of reversed,","
R12348 T15557 T15562 arg1Of reversed,while
R12349 T15560 T15557 arg2Of upregulation,reversed
R12350 T15560 T15558 arg1Of upregulation,defective
R12351 T15560 T15559 arg1Of upregulation,CD80
R12352 T15563 T15564 arg1Of transduction,with
R12353 T15563 T15571 arg1Of transduction,did
R12354 T15567 T15564 arg2Of vector,with
R12355 T15567 T15565 arg1Of vector,an
R12356 T15567 T15566 arg1Of vector,empty
R12357 T15567 T15568 arg1Of vector,(
R12358 T15569 T15568 arg2Of pMIP,(
R12359 T15570 T15568 arg3Of ),(
R12360 T15571 T15562 arg2Of did,while
R12361 T15571 T15572 arg1Of did,not
R12362 T15574 T15573 arg1Of results,Similar
R12363 T15574 T15575 arg1Of results,were
R12364 T15574 T15576 arg2Of results,obtained
R12365 T15576 T15575 arg2Of obtained,were
R12366 T15576 T15577 arg1Of obtained,in
R12367 T15580 T15577 arg2Of experiment,in
R12368 T15580 T15578 arg1Of experiment,a
R12369 T15580 T15579 arg1Of experiment,second
R12576 T15890 T15889 arg1Of transcription,GLε
R12577 T15890 T15891 arg1Of transcription,is
R12578 T15890 T15892 arg1Of transcription,defective
R12579 T15892 T15891 arg2Of defective,is
R12580 T15892 T15893 arg1Of defective,in
R12581 T15896 T15893 arg2Of cells,in
R12582 T15896 T15894 arg1Of cells,CD40-stimulated
R12583 T15896 T15895 arg1Of cells,HOIP-deficient
R12584 T15900 T15897 arg1Of cells,A20.2J
R12585 T15900 T15898 arg1Of cells,and
R12586 T15900 T15899 arg1Of cells,HOIP-deficient
R12587 T15900 T15901 arg2Of cells,transduced
R12588 T15900 T15907 arg1Of cells,(
R12589 T15900 T15919 arg1Of cells,or
R12590 T15901 T15902 arg1Of transduced,with
R12591 T15906 T15902 arg2Of vector,with
R12592 T15906 T15903 arg1Of vector,an
R12593 T15906 T15904 arg1Of vector,empty
R12594 T15906 T15905 arg1Of vector,retroviral
R12595 T15910 T15908 arg1Of pMIP,A20.2J
R12596 T15910 T15909 arg1Of pMIP,+
R12597 T15910 T15911 arg1Of pMIP,and
R12598 T15912 T15911 arg2Of HOIP-/-,and
R12599 T15914 T15907 arg2Of pMIP,(
R12600 T15914 T15910 arg1Of pMIP,pMIP
R12601 T15914 T15912 arg1Of pMIP,HOIP-/-
R12602 T15914 T15913 arg1Of pMIP,+
R12603 T15914 T15915 arg1Of pMIP,","
R12604 T15914 T15916 arg1Of pMIP,respectively
R12605 T15917 T15907 arg3Of ),(
R12606 T15919 T15918 arg1Of or,","
R12607 T15919 T15932 arg1Of or,were
R12608 T15919 T15933 arg2Of or,cultured
R12609 T15921 T15919 arg2Of cells,or
R12610 T15921 T15920 arg1Of cells,HOIP-deficient
R12611 T15921 T15922 arg2Of cells,transduced
R12612 T15922 T15923 arg1Of transduced,with
R12613 T15926 T15923 arg2Of retrovirus,with
R12614 T15926 T15924 arg1Of retrovirus,a
R12615 T15926 T15925 arg1Of retrovirus,HOIP-encoding
R12616 T15926 T15927 arg1Of retrovirus,(
R12617 T15930 T15927 arg2Of HOIP,(
R12618 T15930 T15928 arg1Of HOIP,HOIP-/-
R12619 T15930 T15929 arg1Of HOIP,+
R12620 T15931 T15927 arg3Of ),(
R12621 T15933 T15932 arg2Of cultured,were
R12622 T15933 T15934 arg1Of cultured,overnight
R12623 T15933 T15935 arg1Of cultured,with
R12624 T15933 T15946 arg1Of cultured,","
R12625 T15933 T15947 arg1Of cultured,with
R12626 T15933 T15949 arg1Of cultured,without
R12627 T15937 T15936 arg1Of anti-CD40,agonistic
R12628 T15937 T15938 arg1Of anti-CD40,or
R12629 T15938 T15935 arg2Of or,with
R12630 T15942 T15938 arg2Of antibody,or
R12631 T15942 T15939 arg1Of antibody,an
R12632 T15942 T15940 arg1Of antibody,isotype
R12633 T15942 T15941 arg1Of antibody,control
R12634 T15942 T15943 arg1Of antibody,(
R12635 T15944 T15943 arg2Of iso,(
R12636 T15945 T15943 arg3Of ),(
R12637 T15947 T15948 arg1Of with,or
R12638 T15949 T15948 arg2Of without,or
R12639 T15950 T15947 arg2Of IL-4,with
R12640 T15950 T15949 arg2Of IL-4,without
R12641 T15951 T15952 arg1Of RNA,was
R12642 T15951 T15953 arg2Of RNA,isolated
R12643 T15951 T15962 arg2Of RNA,subjected
R12644 T15953 T15954 arg1Of isolated,from
R12645 T15953 T15960 arg1Of isolated,and
R12646 T15956 T15954 arg2Of cells,from
R12647 T15956 T15955 arg1Of cells,the
R12648 T15956 T15957 arg1Of cells,","
R12649 T15958 T15957 arg2Of reverse-transcribed,","
R12650 T15960 T15952 arg2Of and,was
R12651 T15960 T15959 arg1Of and,","
R12652 T15962 T15960 arg2Of subjected,and
R12653 T15962 T15961 arg1Of subjected,then
R12654 T15962 T15963 arg1Of subjected,to
R12655 T15962 T15966 modOf subjected,to
R12656 T15965 T15963 arg2Of PCR,to
R12657 T15965 T15964 arg1Of PCR,quantitative
R12658 T15967 T15966 arg1Of determine,to
R12659 T15968 T15967 arg2Of levels,determine
R12660 T15968 T15969 arg1Of levels,of
R12661 T15971 T15969 arg2Of transcripts,of
R12662 T15971 T15970 arg1Of transcripts,GLε
R12663 T15972 T15973 arg1Of Results,were
R12664 T15972 T15974 arg2Of Results,normalized
R12665 T15974 T15973 arg2Of normalized,were
R12666 T15974 T15975 arg1Of normalized,to
R12667 T15977 T15975 arg2Of levels,to
R12668 T15977 T15976 arg1Of levels,the
R12669 T15977 T15978 arg1Of levels,of
R12670 T15977 T15981 arg1Of levels,in
R12671 T15980 T15978 arg2Of transcripts,of
R12672 T15980 T15979 arg1Of transcripts,Hprt1
R12673 T15983 T15981 arg2Of sample,in
R12674 T15983 T15982 arg1Of sample,each
R12675 T15984 T15985 arg1Of Symbols,indicate
R12676 T15985 T15991 arg1Of indicate,(
R12677 T15987 T15985 arg2Of values,indicate
R12678 T15987 T15986 arg1Of values,the
R12679 T15987 T15988 arg1Of values,from
R12680 T15990 T15988 arg2Of cultures,from
R12681 T15990 T15989 arg1Of cultures,duplicate
R12682 T15993 T15992 arg1Of line,a
R12683 T15993 T15994 arg1Of line,indicates
R12684 T15994 T15991 arg2Of indicates,(
R12685 T15996 T15994 arg2Of mean,indicates
R12686 T15996 T15995 arg1Of mean,the
R12687 T15996 T15997 arg1Of mean,of
R12688 T16000 T15997 arg2Of values,of
R12689 T16000 T15998 arg1Of values,the
R12690 T16000 T15999 arg1Of values,two
R12691 T16001 T15991 arg3Of ),(
R12692 T16003 T16002 arg1Of results,Similar
R12693 T16003 T16004 arg1Of results,were
R12694 T16003 T16005 arg2Of results,obtained
R12695 T16005 T16004 arg2Of obtained,were
R12696 T16005 T16006 arg1Of obtained,in
R12697 T16005 T16011 arg1Of obtained,in
R12698 T16005 T16015 arg1Of obtained,with
R12699 T16006 T16010 arg1Of in,and
R12700 T16009 T16006 arg2Of experiment,in
R12701 T16009 T16007 arg1Of experiment,a
R12702 T16009 T16008 arg1Of experiment,second
R12703 T16011 T16010 arg2Of in,and
R12704 T16014 T16011 arg2Of experiment,in
R12705 T16014 T16012 arg1Of experiment,an
R12706 T16014 T16013 arg1Of experiment,additional
R12707 T16019 T16015 arg2Of clone,with
R12708 T16019 T16016 arg1Of clone,a
R12709 T16019 T16017 arg1Of clone,second
R12710 T16019 T16018 arg1Of clone,HOIP-deficient

2_test

Id Subject Object Predicate Lexical cue
21829693-7681471-89653762 164-166 7681471 denotes 10
21829693-7681587-89653763 1548-1550 7681587 denotes 11
21829693-1701824-89653764 1554-1556 1701824 denotes 12
21829693-12949496-89653765 2038-2040 12949496 denotes 13
T72061 164-166 7681471 denotes 10
T18517 1548-1550 7681587 denotes 11
T73302 1554-1556 1701824 denotes 12
T513 2038-2040 12949496 denotes 13

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T4259 0-4 NNP denotes HOIP
T4260 5-7 VBZ denotes is
T4261 8-16 VBN denotes required
T4262 17-20 IN denotes for
T4263 21-34 JJ denotes CD40-mediated
T4264 35-39 NN denotes CD80
T4265 40-52 NN denotes upregulation
T4266 53-56 CC denotes and
T4267 57-67 NN denotes activation
T4268 68-70 IN denotes of
T4269 71-79 NN denotes germline
T4270 80-87 NN denotes epsilon
T4271 88-101 NN denotes transcription
T4272 102-112 NNP denotes Engagement
T4273 113-115 IN denotes of
T4274 116-120 NNP denotes CD40
T4275 121-123 IN denotes on
T4276 124-125 NNP denotes B
T4277 126-131 NNS denotes cells
T4278 132-143 VBZ denotes upregulates
T4279 144-154 NN denotes expression
T4280 155-157 IN denotes of
T4281 158-162 NNP denotes CD80
T4282 163-164 NNP denotes [
T4283 164-166 CD denotes 10
T4284 166-167 NNP denotes ]
T4285 167-168 , denotes ,
T4286 169-170 DT denotes a
T4287 171-175 NN denotes cell
T4288 176-183 NN denotes surface
T4289 184-191 NN denotes protein
T4290 192-196 WDT denotes that
T4291 197-205 VBZ denotes promotes
T4292 206-216 NN denotes activation
T4293 217-219 IN denotes of
T4294 220-221 NNP denotes T
T4295 222-227 NNS denotes cells
T4296 228-239 VBG denotes interacting
T4297 240-244 IN denotes with
T4298 245-246 NNP denotes B
T4299 247-252 NNS denotes cells
T4300 253-256 CC denotes and
T4301 257-262 JJ denotes other
T4302 263-266 NNP denotes APC
T4303 266-267 . denotes .
T4304 268-270 TO denotes To
T4305 271-276 VB denotes begin
T4306 277-287 VBG denotes evaluating
T4307 288-297 JJ denotes potential
T4308 298-311 NNS denotes contributions
T4309 312-314 IN denotes of
T4310 315-319 NNP denotes HOIP
T4311 320-322 TO denotes to
T4312 323-327 NNP denotes CD40
T4313 328-337 VBG denotes signaling
T4314 337-338 , denotes ,
T4315 339-341 PRP denotes we
T4316 342-349 VBD denotes assayed
T4317 350-353 DT denotes the
T4318 354-366 NN denotes upregulation
T4319 367-369 IN denotes of
T4320 370-374 CD denotes CD80
T4321 375-382 VBN denotes induced
T4322 383-385 IN denotes by
T4323 386-396 NN denotes engagement
T4324 397-399 IN denotes of
T4325 400-404 NNP denotes CD40
T4326 405-407 IN denotes on
T4327 408-416 JJ denotes parental
T4328 417-420 NNP denotes A20
T4329 420-422 CD denotes .2
T4330 422-423 NNP denotes J
T4331 423-424 , denotes ,
T4332 425-439 NNP denotes HOIP-deficient
T4333 439-440 , denotes ,
T4334 441-444 CC denotes and
T4335 445-463 JJ denotes HOIP-reconstituted
T4336 464-469 NNS denotes cells
T4337 470-471 -LRB- denotes (
T4338 471-475 JJ denotes Fig.
T4339 476-477 CD denotes 2
T4340 477-478 -RRB- denotes )
T4341 478-479 . denotes .
T4342 480-488 VBN denotes Compared
T4343 489-491 TO denotes to
T4344 492-495 DT denotes the
T4345 496-504 JJ denotes parental
T4346 505-509 NN denotes cell
T4347 510-514 NN denotes line
T4348 514-515 , denotes ,
T4349 516-519 DT denotes the
T4350 520-535 JJ denotes CD40-stimulated
T4351 536-548 NN denotes upregulation
T4352 549-551 IN denotes of
T4353 552-556 NN denotes CD80
T4354 557-560 VBD denotes was
T4355 561-573 RB denotes dramatically
T4356 574-581 VBN denotes reduced
T4357 582-584 IN denotes in
T4358 585-588 DT denotes all
T4359 589-603 JJ denotes HOIP-deficient
T4360 604-609 NNS denotes cells
T4361 610-616 VBN denotes tested
T4362 616-617 . denotes .
T4363 618-620 IN denotes In
T4364 621-629 NN denotes contrast
T4365 629-630 , denotes ,
T4366 631-643 NN denotes upregulation
T4367 644-646 IN denotes of
T4368 647-651 NN denotes CD80
T4369 652-655 VBD denotes was
T4370 656-664 VBN denotes restored
T4371 665-667 IN denotes in
T4372 668-686 JJ denotes HOIP-reconstituted
T4373 687-692 NNS denotes cells
T4374 692-693 , denotes ,
T4375 694-704 VBG denotes confirming
T4376 705-709 IN denotes that
T4377 710-713 DT denotes the
T4378 714-720 NN denotes defect
T4379 721-723 IN denotes in
T4380 724-728 NNP denotes CD80
T4381 729-741 NN denotes upregulation
T4382 742-744 IN denotes in
T4383 745-748 DT denotes the
T4384 749-763 JJ denotes HOIP-deficient
T4385 764-769 NNS denotes cells
T4386 770-773 VBD denotes was
T4387 774-777 JJ denotes due
T4388 778-780 TO denotes to
T4389 781-784 DT denotes the
T4390 785-795 NN denotes disruption
T4391 796-798 IN denotes of
T4392 799-804 NNP denotes Rnf31
T4393 804-805 . denotes .
T4394 1424-1428 CD denotes CD40
T4395 1429-1436 NNS denotes signals
T4396 1437-1439 IN denotes in
T4397 1440-1441 NNP denotes B
T4398 1442-1447 NNS denotes cells
T4399 1448-1451 MD denotes can
T4400 1452-1456 RB denotes also
T4401 1457-1467 VB denotes contribute
T4402 1468-1470 TO denotes to
T4403 1471-1474 DT denotes the
T4404 1475-1485 NN denotes activation
T4405 1486-1488 IN denotes of
T4406 1489-1492 NNP denotes DNA
T4407 1493-1506 NN denotes recombination
T4408 1507-1509 IN denotes in
T4409 1510-1513 DT denotes the
T4410 1514-1528 NN denotes immunoglobulin
T4411 1529-1534 JJ denotes heavy
T4412 1535-1540 NN denotes chain
T4413 1541-1546 NN denotes locus
T4414 1547-1548 NNP denotes [
T4415 1548-1550 CD denotes 11
T4416 1550-1551 NNP denotes ]
T4417 1551-1552 , denotes ,
T4418 1553-1554 NNP denotes [
T4419 1554-1556 CD denotes 12
T4420 1556-1557 NNP denotes ]
T4421 1557-1558 . denotes .
T4422 1559-1563 DT denotes This
T4423 1564-1571 NN denotes process
T4424 1571-1572 , denotes ,
T4425 1573-1578 VBN denotes known
T4426 1579-1581 IN denotes as
T4427 1582-1596 JJ denotes immunoglobulin
T4428 1597-1602 NN denotes class
T4429 1603-1612 NN denotes switching
T4430 1613-1614 -LRB- denotes (
T4431 1614-1616 CC denotes or
T4432 1617-1624 JJ denotes isotype
T4433 1625-1634 NN denotes switching
T4434 1634-1635 -RRB- denotes )
T4435 1635-1636 , denotes ,
T4436 1637-1643 VBZ denotes allows
T4437 1644-1645 NNP denotes B
T4438 1646-1651 NNS denotes cells
T4439 1651-1652 , denotes ,
T4440 1653-1662 RB denotes initially
T4441 1663-1673 VBG denotes expressing
T4442 1674-1677 NNP denotes IgM
T4443 1677-1678 , denotes ,
T4444 1679-1681 TO denotes to
T4445 1682-1688 VB denotes switch
T4446 1689-1691 TO denotes to
T4447 1692-1695 NNP denotes IgA
T4448 1695-1696 , denotes ,
T4449 1697-1700 NNP denotes IgG
T4450 1700-1701 , denotes ,
T4451 1702-1704 CC denotes or
T4452 1705-1708 NNP denotes IgE
T4453 1709-1718 VBG denotes depending
T4454 1719-1721 IN denotes on
T4455 1722-1725 DT denotes the
T4456 1726-1731 NN denotes class
T4457 1732-1734 IN denotes of
T4458 1735-1743 NN denotes antibody
T4459 1744-1748 RBS denotes most
T4460 1749-1760 JJ denotes appropriate
T4461 1761-1764 IN denotes for
T4462 1765-1766 DT denotes a
T4463 1767-1777 JJ denotes particular
T4464 1778-1784 JJ denotes immune
T4465 1785-1793 NN denotes response
T4466 1793-1794 . denotes .
T4467 1795-1804 VBG denotes Switching
T4468 1805-1807 TO denotes to
T4469 1808-1811 NNP denotes IgE
T4470 1812-1815 MD denotes can
T4471 1816-1818 VB denotes be
T4472 1819-1826 VBN denotes induced
T4473 1827-1829 IN denotes by
T4474 1830-1833 DT denotes the
T4475 1834-1845 NN denotes combination
T4476 1846-1848 IN denotes of
T4477 1849-1853 NN denotes IL-4
T4478 1854-1857 CC denotes and
T4479 1858-1862 JJ denotes CD40
T4480 1863-1870 NNS denotes signals
T4481 1870-1871 . denotes .
T4482 1872-1875 DT denotes The
T4483 1876-1880 NN denotes gene
T4484 1881-1894 NN denotes rearrangement
T4485 1895-1904 JJ denotes necessary
T4486 1905-1908 IN denotes for
T4487 1909-1912 JJ denotes IgE
T4488 1913-1923 NN denotes production
T4489 1924-1926 VBZ denotes is
T4490 1927-1935 VBN denotes preceded
T4491 1936-1938 IN denotes by
T4492 1939-1942 DT denotes the
T4493 1943-1953 NN denotes production
T4494 1954-1956 IN denotes of
T4495 1957-1967 JJ denotes non-coding
T4496 1968-1971 NNP denotes RNA
T4497 1972-1983 NNS denotes transcripts
T4498 1984-1988 IN denotes from
T4499 1989-1997 JJ denotes germline
T4500 1998-2007 NNS denotes sequences
T4501 2008-2010 IN denotes in
T4502 2011-2014 DT denotes the
T4503 2015-2018 NNP denotes IgE
T4504 2019-2024 NN denotes heavy
T4505 2025-2030 NN denotes chain
T4506 2031-2036 VBZ denotes locus
T4507 2037-2038 NNP denotes [
T4508 2038-2040 CD denotes 13
T4509 2040-2041 NNP denotes ]
T4510 2041-2042 . denotes .
T4511 2043-2045 TO denotes To
T4512 2046-2055 VB denotes determine
T4513 2056-2063 IN denotes whether
T4514 2064-2068 NNP denotes HOIP
T4515 2069-2071 VBZ denotes is
T4516 2072-2080 VBN denotes required
T4517 2081-2083 IN denotes in
T4518 2084-2087 DT denotes the
T4519 2088-2098 NN denotes initiation
T4520 2099-2101 IN denotes of
T4521 2102-2105 DT denotes the
T4522 2106-2111 NN denotes class
T4523 2112-2121 VBG denotes switching
T4524 2122-2129 NN denotes process
T4525 2129-2130 , denotes ,
T4526 2131-2134 DT denotes the
T4527 2135-2143 JJ denotes relevant
T4528 2144-2145 NNP denotes B
T4529 2146-2150 NN denotes cell
T4530 2151-2156 NNS denotes lines
T4531 2157-2161 VBD denotes were
T4532 2162-2172 VBN denotes stimulated
T4533 2173-2180 IN denotes through
T4534 2181-2185 NNP denotes CD40
T4535 2186-2188 IN denotes in
T4536 2189-2192 DT denotes the
T4537 2193-2201 NN denotes presence
T4538 2202-2204 IN denotes of
T4539 2205-2209 NN denotes IL-4
T4540 2210-2213 CC denotes and
T4541 2214-2220 VBN denotes tested
T4542 2221-2224 IN denotes for
T4543 2225-2235 NN denotes production
T4544 2236-2238 IN denotes of
T4545 2239-2247 NN denotes germline
T4546 2248-2255 NN denotes epsilon
T4547 2256-2257 -LRB- denotes (
T4548 2257-2260 NNP denotes GLε
T4549 2260-2261 -RRB- denotes )
T4550 2262-2273 NNS denotes transcripts
T4551 2274-2275 -LRB- denotes (
T4552 2275-2279 JJ denotes Fig.
T4553 2280-2281 CD denotes 3
T4554 2281-2282 -RRB- denotes )
T4555 2282-2283 . denotes .
T4556 2284-2293 JJ denotes Anti-CD40
T4557 2294-2302 NN denotes antibody
T4558 2303-2314 NN denotes stimulation
T4559 2315-2320 RB denotes alone
T4560 2321-2323 CC denotes or
T4561 2324-2332 RB denotes together
T4562 2333-2337 IN denotes with
T4563 2338-2342 NN denotes IL-4
T4564 2343-2350 VBD denotes induced
T4565 2351-2354 NNP denotes GLε
T4566 2355-2368 NN denotes transcription
T4567 2369-2371 IN denotes in
T4568 2372-2380 JJ denotes parental
T4569 2381-2384 NNP denotes A20
T4570 2384-2386 CD denotes .2
T4571 2386-2387 NNP denotes J
T4572 2388-2393 NNS denotes cells
T4573 2394-2396 IN denotes as
T4574 2397-2405 VBN denotes expected
T4575 2405-2406 . denotes .
T4576 2407-2409 IN denotes In
T4577 2410-2418 NN denotes contrast
T4578 2418-2419 , denotes ,
T4579 2420-2424 RB denotes only
T4580 2425-2428 JJ denotes low
T4581 2429-2435 NNS denotes levels
T4582 2436-2438 IN denotes of
T4583 2439-2442 NNP denotes GLε
T4584 2443-2453 NN denotes expression
T4585 2454-2458 VBD denotes were
T4586 2459-2467 VBN denotes detected
T4587 2468-2470 IN denotes in
T4588 2471-2485 JJ denotes HOIP-deficient
T4589 2486-2491 NNS denotes cells
T4590 2492-2502 VBN denotes stimulated
T4591 2503-2507 IN denotes with
T4592 2508-2514 DT denotes either
T4593 2515-2524 JJ denotes anti-CD40
T4594 2525-2533 NN denotes antibody
T4595 2534-2539 RB denotes alone
T4596 2540-2542 CC denotes or
T4597 2543-2552 JJ denotes anti-CD40
T4598 2553-2556 CC denotes and
T4599 2557-2561 NN denotes IL-4
T4600 2561-2562 . denotes .
T4601 2563-2569 JJ denotes Normal
T4602 2570-2576 NNS denotes levels
T4603 2577-2579 IN denotes of
T4604 2580-2583 NNP denotes GLε
T4605 2584-2594 NN denotes expression
T4606 2595-2599 VBD denotes were
T4607 2600-2607 VBN denotes induced
T4608 2608-2610 IN denotes in
T4609 2611-2629 JJ denotes HOIP-reconstituted
T4610 2630-2635 NNS denotes cells
T4611 2636-2646 VBN denotes stimulated
T4612 2647-2651 IN denotes with
T4613 2652-2661 JJ denotes anti-CD40
T4614 2662-2670 NN denotes antibody
T4615 2671-2676 RB denotes alone
T4616 2677-2679 CC denotes or
T4617 2680-2688 RB denotes together
T4618 2689-2693 IN denotes with
T4619 2694-2698 NN denotes IL-4
T4620 2698-2699 . denotes .
T4621 2700-2712 RB denotes Collectively
T4622 2712-2713 , denotes ,
T4623 2714-2719 DT denotes these
T4624 2720-2724 NNS denotes data
T4625 2725-2736 VBP denotes demonstrate
T4626 2737-2741 IN denotes that
T4627 2742-2746 NNP denotes HOIP
T4628 2747-2750 VBZ denotes has
T4629 2751-2752 DT denotes a
T4630 2753-2761 JJ denotes critical
T4631 2762-2766 NN denotes role
T4632 2767-2769 IN denotes in
T4633 2770-2778 JJ denotes cellular
T4634 2779-2788 NNS denotes responses
T4635 2789-2791 TO denotes to
T4636 2792-2796 CD denotes CD40
T4637 2797-2806 VBG denotes signaling
T4638 2806-2807 . denotes .
T15392 850-863 JJ denotes CD40-mediated
T15393 864-868 NN denotes CD80
T15394 869-881 NN denotes upregulation
T15395 882-884 VBZ denotes is
T15396 885-894 JJ denotes defective
T15397 895-897 IN denotes in
T15398 898-912 JJ denotes HOIP-deficient
T15399 913-918 NNS denotes cells
T15400 918-919 . denotes .
T15401 920-925 NNS denotes Cells
T15402 926-930 VBD denotes were
T15403 931-940 VBN denotes incubated
T15404 941-944 IN denotes for
T15405 945-947 CD denotes 72
T15406 948-951 NNS denotes hrs
T15407 952-956 IN denotes with
T15408 957-959 DT denotes an
T15409 960-967 NN denotes isotype
T15410 968-975 NN denotes control
T15411 976-984 NN denotes antibody
T15412 985-986 -LRB- denotes (
T15413 986-990 VBN denotes left
T15414 990-991 -RRB- denotes )
T15415 992-994 CC denotes or
T15416 995-1004 JJ denotes anti-CD40
T15417 1005-1013 NN denotes antibody
T15418 1014-1015 -LRB- denotes (
T15419 1015-1020 NN denotes right
T15420 1020-1021 -RRB- denotes )
T15421 1022-1025 CC denotes and
T15422 1026-1030 RB denotes then
T15423 1031-1038 VBD denotes stained
T15424 1039-1042 IN denotes for
T15425 1043-1053 NN denotes expression
T15426 1054-1056 IN denotes of
T15427 1057-1061 NNP denotes CD80
T15428 1062-1063 -LRB- denotes (
T15429 1063-1069 VBN denotes filled
T15430 1070-1078 NNS denotes profiles
T15431 1079-1087 VBP denotes indicate
T15432 1088-1096 VBG denotes staining
T15433 1097-1101 IN denotes with
T15434 1102-1111 JJ denotes anti-CD80
T15435 1112-1120 NN denotes antibody
T15436 1120-1121 : denotes ;
T15437 1122-1126 JJ denotes open
T15438 1127-1135 NNS denotes profiles
T15439 1136-1139 VBP denotes are
T15440 1140-1148 VBG denotes staining
T15441 1149-1153 IN denotes with
T15442 1154-1156 DT denotes an
T15443 1157-1164 NN denotes isotype
T15444 1165-1172 NN denotes control
T15445 1173-1181 NN denotes antibody
T15446 1181-1182 -RRB- denotes )
T15447 1182-1183 . denotes .
T15448 1184-1196 NNP denotes Transduction
T15449 1197-1199 IN denotes of
T15450 1200-1204 DT denotes both
T15451 1205-1219 JJ denotes HOIP-deficient
T15452 1220-1221 -LRB- denotes (
T15453 1221-1225 SYM denotes HOIP
T15454 1225-1226 : denotes -
T15455 1226-1227 SYM denotes /
T15456 1227-1228 : denotes -
T15457 1228-1229 -RRB- denotes )
T15458 1230-1236 NNS denotes clones
T15459 1237-1241 IN denotes with
T15460 1242-1243 DT denotes a
T15461 1244-1254 NN denotes retrovirus
T15462 1255-1263 VBG denotes encoding
T15463 1264-1273 NNP denotes FLAG-HOIP
T15464 1274-1282 VBD denotes reversed
T15465 1283-1292 JJ denotes defective
T15466 1293-1297 NNP denotes CD80
T15467 1298-1310 NN denotes upregulation
T15468 1310-1311 , denotes ,
T15469 1312-1317 IN denotes while
T15470 1318-1330 NN denotes transduction
T15471 1331-1335 IN denotes with
T15472 1336-1338 DT denotes an
T15473 1339-1344 JJ denotes empty
T15474 1345-1351 NN denotes vector
T15475 1352-1353 -LRB- denotes (
T15476 1353-1357 NNP denotes pMIP
T15477 1357-1358 -RRB- denotes )
T15478 1359-1362 VBD denotes did
T15479 1363-1366 RB denotes not
T15480 1366-1367 . denotes .
T15481 1368-1375 JJ denotes Similar
T15482 1376-1383 NNS denotes results
T15483 1384-1388 VBD denotes were
T15484 1389-1397 VBN denotes obtained
T15485 1398-1400 IN denotes in
T15486 1401-1402 DT denotes a
T15487 1403-1409 JJ denotes second
T15488 1410-1420 NN denotes experiment
T15489 1420-1421 . denotes .
T15742 2852-2855 NNP denotes GLε
T15743 2856-2869 NN denotes transcription
T15744 2870-2872 VBZ denotes is
T15745 2873-2882 JJ denotes defective
T15746 2883-2885 IN denotes in
T15747 2886-2901 JJ denotes CD40-stimulated
T15748 2902-2916 JJ denotes HOIP-deficient
T15749 2917-2922 NNS denotes cells
T15750 2922-2923 . denotes .
T15751 2924-2927 CD denotes A20
T15752 2927-2929 CD denotes .2
T15753 2929-2930 NNP denotes J
T15754 2931-2934 CC denotes and
T15755 2935-2949 JJ denotes HOIP-deficient
T15756 2950-2955 NNS denotes cells
T15757 2956-2966 VBN denotes transduced
T15758 2967-2971 IN denotes with
T15759 2972-2974 DT denotes an
T15760 2975-2980 JJ denotes empty
T15761 2981-2991 NN denotes retroviral
T15762 2992-2998 NN denotes vector
T15763 2999-3000 -LRB- denotes (
T15764 3000-3003 CD denotes A20
T15765 3003-3005 CD denotes .2
T15766 3005-3006 NNP denotes J
T15767 3007-3008 CD denotes +
T15768 3009-3013 NNP denotes pMIP
T15769 3014-3017 CC denotes and
T15770 3018-3022 NNP denotes HOIP
T15771 3022-3023 : denotes -
T15772 3023-3024 SYM denotes /
T15773 3024-3025 : denotes -
T15774 3026-3027 NN denotes +
T15775 3028-3032 NNP denotes pMIP
T15776 3032-3033 , denotes ,
T15777 3034-3046 RB denotes respectively
T15778 3046-3047 -RRB- denotes )
T15779 3047-3048 , denotes ,
T15780 3049-3051 CC denotes or
T15781 3052-3066 JJ denotes HOIP-deficient
T15782 3067-3072 NNS denotes cells
T15783 3073-3083 VBN denotes transduced
T15784 3084-3088 IN denotes with
T15785 3089-3090 DT denotes a
T15786 3091-3104 JJ denotes HOIP-encoding
T15787 3105-3115 NN denotes retrovirus
T15788 3116-3117 -LRB- denotes (
T15789 3117-3121 SYM denotes HOIP
T15790 3121-3122 : denotes -
T15791 3122-3123 SYM denotes /
T15792 3123-3124 : denotes -
T15793 3125-3126 NN denotes +
T15794 3127-3131 NNP denotes HOIP
T15795 3131-3132 -RRB- denotes )
T15796 3133-3137 VBD denotes were
T15797 3138-3146 VBN denotes cultured
T15798 3147-3156 JJ denotes overnight
T15799 3157-3161 IN denotes with
T15800 3162-3171 JJ denotes agonistic
T15801 3172-3181 JJ denotes anti-CD40
T15802 3182-3184 CC denotes or
T15803 3185-3187 DT denotes an
T15804 3188-3195 NN denotes isotype
T15805 3196-3203 NN denotes control
T15806 3204-3212 NN denotes antibody
T15807 3213-3214 -LRB- denotes (
T15808 3214-3217 FW denotes iso
T15809 3217-3218 -RRB- denotes )
T15810 3218-3219 , denotes ,
T15811 3220-3224 IN denotes with
T15812 3225-3227 CC denotes or
T15813 3228-3235 IN denotes without
T15814 3236-3240 NN denotes IL-4
T15815 3240-3241 . denotes .
T15816 3242-3245 NNP denotes RNA
T15817 3246-3249 VBD denotes was
T15818 3250-3258 VBN denotes isolated
T15819 3259-3263 IN denotes from
T15820 3264-3267 DT denotes the
T15821 3268-3273 NNS denotes cells
T15822 3273-3274 , denotes ,
T15823 3275-3294 JJ denotes reverse-transcribed
T15824 3294-3295 , denotes ,
T15825 3296-3299 CC denotes and
T15826 3300-3304 RB denotes then
T15827 3305-3314 VBN denotes subjected
T15828 3315-3317 TO denotes to
T15829 3318-3330 JJ denotes quantitative
T15830 3331-3334 NNP denotes PCR
T15831 3335-3337 TO denotes to
T15832 3338-3347 VB denotes determine
T15833 3348-3354 NNS denotes levels
T15834 3355-3357 IN denotes of
T15835 3358-3361 NNP denotes GLε
T15836 3362-3373 NNS denotes transcripts
T15837 3373-3374 . denotes .
T15838 3375-3382 NNS denotes Results
T15839 3383-3387 VBD denotes were
T15840 3388-3398 VBN denotes normalized
T15841 3399-3401 TO denotes to
T15842 3402-3405 DT denotes the
T15843 3406-3412 NNS denotes levels
T15844 3413-3415 IN denotes of
T15845 3416-3421 JJ denotes Hprt1
T15846 3422-3433 NNS denotes transcripts
T15847 3434-3436 IN denotes in
T15848 3437-3441 DT denotes each
T15849 3442-3448 NN denotes sample
T15850 3448-3449 . denotes .
T15851 3450-3457 NNS denotes Symbols
T15852 3458-3466 VBP denotes indicate
T15853 3467-3470 DT denotes the
T15854 3471-3477 NNS denotes values
T15855 3478-3482 IN denotes from
T15856 3483-3492 VBP denotes duplicate
T15857 3493-3501 NNS denotes cultures
T15858 3502-3503 -LRB- denotes (
T15859 3503-3504 DT denotes a
T15860 3505-3509 NN denotes line
T15861 3510-3519 VBZ denotes indicates
T15862 3520-3523 DT denotes the
T15863 3524-3528 NN denotes mean
T15864 3529-3531 IN denotes of
T15865 3532-3535 DT denotes the
T15866 3536-3539 CD denotes two
T15867 3540-3546 NNS denotes values
T15868 3546-3547 -RRB- denotes )
T15869 3547-3548 . denotes .
T15870 3549-3556 JJ denotes Similar
T15871 3557-3564 NNS denotes results
T15872 3565-3569 VBD denotes were
T15873 3570-3578 VBN denotes obtained
T15874 3579-3581 IN denotes in
T15875 3582-3583 DT denotes a
T15876 3584-3590 JJ denotes second
T15877 3591-3601 NN denotes experiment
T15878 3602-3605 CC denotes and
T15879 3606-3608 IN denotes in
T15880 3609-3611 DT denotes an
T15881 3612-3622 JJ denotes additional
T15882 3623-3633 NN denotes experiment
T15883 3634-3638 IN denotes with
T15884 3639-3640 DT denotes a
T15885 3641-3647 JJ denotes second
T15886 3648-3662 JJ denotes HOIP-deficient
T15887 3663-3668 NN denotes clone
T15888 3668-3669 . denotes .
R3249 T4259 T4261 nsubjpass HOIP,required
R3250 T4260 T4261 auxpass is,required
R3251 T4261 T4261 ROOT required,required
R3252 T4262 T4261 prep for,required
R3253 T4263 T4265 amod CD40-mediated,upregulation
R3254 T4264 T4265 compound CD80,upregulation
R3255 T4265 T4262 pobj upregulation,for
R3256 T4266 T4265 cc and,upregulation
R3257 T4267 T4265 conj activation,upregulation
R3258 T4268 T4267 prep of,activation
R3259 T4269 T4271 compound germline,transcription
R3260 T4270 T4271 compound epsilon,transcription
R3261 T4271 T4268 pobj transcription,of
R3262 T4272 T4265 conj Engagement,upregulation
R3263 T4273 T4272 prep of,Engagement
R3264 T4274 T4273 pobj CD40,of
R3265 T4275 T4272 prep on,Engagement
R3266 T4276 T4277 compound B,cells
R3267 T4277 T4275 pobj cells,on
R3268 T4278 T4279 compound upregulates,expression
R3269 T4279 T4261 dobj expression,required
R3270 T4280 T4279 prep of,expression
R3271 T4281 T4282 compound CD80,[
R3272 T4282 T4280 pobj [,of
R3273 T4283 T4284 nummod 10,]
R3274 T4284 T4279 appos ],expression
R3275 T4285 T4284 punct ",",]
R3276 T4286 T4289 det a,protein
R3277 T4287 T4288 compound cell,surface
R3278 T4288 T4289 compound surface,protein
R3279 T4289 T4279 appos protein,expression
R3280 T4290 T4291 nsubj that,promotes
R3281 T4291 T4289 relcl promotes,protein
R3282 T4292 T4291 dobj activation,promotes
R3283 T4293 T4292 prep of,activation
R3284 T4294 T4295 compound T,cells
R3285 T4295 T4293 pobj cells,of
R3286 T4296 T4295 acl interacting,cells
R3287 T4297 T4296 prep with,interacting
R3288 T4298 T4299 compound B,cells
R3289 T4299 T4297 pobj cells,with
R3290 T4300 T4299 cc and,cells
R3291 T4301 T4302 amod other,APC
R3292 T4302 T4299 conj APC,cells
R3293 T4303 T4261 punct .,required
R3294 T4304 T4305 aux To,begin
R3295 T4305 T4316 advcl begin,assayed
R3296 T4306 T4305 xcomp evaluating,begin
R3297 T4307 T4308 amod potential,contributions
R3298 T4308 T4306 dobj contributions,evaluating
R3299 T4309 T4308 prep of,contributions
R3300 T4310 T4309 pobj HOIP,of
R3301 T4311 T4306 prep to,evaluating
R3302 T4312 T4313 nsubj CD40,signaling
R3303 T4313 T4311 pcomp signaling,to
R3304 T4314 T4316 punct ",",assayed
R3305 T4315 T4316 nsubj we,assayed
R3306 T4316 T4316 ROOT assayed,assayed
R3307 T4317 T4318 det the,upregulation
R3308 T4318 T4316 dobj upregulation,assayed
R3309 T4319 T4318 prep of,upregulation
R3310 T4320 T4319 pobj CD80,of
R3311 T4321 T4318 acl induced,upregulation
R3312 T4322 T4321 agent by,induced
R3313 T4323 T4322 pobj engagement,by
R3314 T4324 T4323 prep of,engagement
R3315 T4325 T4324 pobj CD40,of
R3316 T4326 T4323 prep on,engagement
R3317 T4327 T4330 amod parental,J
R3318 T4328 T4330 nmod A20,J
R3319 T4329 T4330 nummod .2,J
R3320 T4330 T4326 pobj J,on
R3321 T4331 T4330 punct ",",J
R3322 T4332 T4330 conj HOIP-deficient,J
R3323 T4333 T4332 punct ",",HOIP-deficient
R3324 T4334 T4332 cc and,HOIP-deficient
R3325 T4335 T4336 amod HOIP-reconstituted,cells
R3326 T4336 T4332 conj cells,HOIP-deficient
R3327 T4337 T4338 punct (,Fig.
R3328 T4338 T4336 parataxis Fig.,cells
R3329 T4339 T4338 nummod 2,Fig.
R3330 T4340 T4338 punct ),Fig.
R3331 T4341 T4316 punct .,assayed
R3332 T4342 T4356 prep Compared,reduced
R3333 T4343 T4342 prep to,Compared
R3334 T4344 T4347 det the,line
R3335 T4345 T4347 amod parental,line
R3336 T4346 T4347 compound cell,line
R3337 T4347 T4343 pobj line,to
R3338 T4348 T4347 punct ",",line
R3339 T4349 T4351 det the,upregulation
R3340 T4350 T4351 amod CD40-stimulated,upregulation
R3341 T4351 T4356 nsubjpass upregulation,reduced
R3342 T4352 T4351 prep of,upregulation
R3343 T4353 T4352 pobj CD80,of
R3344 T4354 T4356 auxpass was,reduced
R3345 T4355 T4356 advmod dramatically,reduced
R3346 T4356 T4356 ROOT reduced,reduced
R3347 T4357 T4356 prep in,reduced
R3348 T4358 T4360 det all,cells
R3349 T4359 T4360 amod HOIP-deficient,cells
R3350 T4360 T4357 pobj cells,in
R3351 T4361 T4356 conj tested,reduced
R3352 T4362 T4356 punct .,reduced
R3353 T4363 T4370 prep In,restored
R3354 T4364 T4363 pobj contrast,In
R3355 T4365 T4370 punct ",",restored
R3356 T4366 T4370 nsubjpass upregulation,restored
R3357 T4367 T4366 prep of,upregulation
R3358 T4368 T4367 pobj CD80,of
R3359 T4369 T4370 auxpass was,restored
R3360 T4370 T4370 ROOT restored,restored
R3361 T4371 T4370 prep in,restored
R3362 T4372 T4373 amod HOIP-reconstituted,cells
R3363 T4373 T4371 pobj cells,in
R3364 T4374 T4370 punct ",",restored
R3365 T4375 T4370 advcl confirming,restored
R3366 T4376 T4386 mark that,was
R3367 T4377 T4378 det the,defect
R3368 T4378 T4386 nsubj defect,was
R3369 T4379 T4378 prep in,defect
R3370 T4380 T4381 compound CD80,upregulation
R3371 T4381 T4379 pobj upregulation,in
R3372 T4382 T4381 prep in,upregulation
R3373 T4383 T4385 det the,cells
R3374 T4384 T4385 amod HOIP-deficient,cells
R3375 T4385 T4382 pobj cells,in
R3376 T4386 T4375 ccomp was,confirming
R3377 T4387 T4386 acomp due,was
R3378 T4388 T4387 prep to,due
R3379 T4389 T4390 det the,disruption
R3380 T4390 T4388 pobj disruption,to
R3381 T4391 T4390 prep of,disruption
R3382 T4392 T4391 pobj Rnf31,of
R3383 T4393 T4370 punct .,restored
R3384 T4394 T4395 nummod CD40,signals
R3385 T4395 T4401 nsubj signals,contribute
R3386 T4396 T4395 prep in,signals
R3387 T4397 T4398 compound B,cells
R3388 T4398 T4396 pobj cells,in
R3389 T4399 T4401 aux can,contribute
R3390 T4400 T4401 advmod also,contribute
R3391 T4401 T4401 ROOT contribute,contribute
R3392 T4402 T4401 prep to,contribute
R3393 T4403 T4404 det the,activation
R3394 T4404 T4402 pobj activation,to
R3395 T4405 T4404 prep of,activation
R3396 T4406 T4407 compound DNA,recombination
R3397 T4407 T4405 pobj recombination,of
R3398 T4408 T4404 prep in,activation
R3399 T4409 T4413 det the,locus
R3400 T4410 T4413 compound immunoglobulin,locus
R3401 T4411 T4412 amod heavy,chain
R3402 T4412 T4413 compound chain,locus
R3403 T4413 T4408 pobj locus,in
R3404 T4414 T4416 compound [,]
R3405 T4415 T4416 compound 11,]
R3406 T4416 T4404 appos ],activation
R3407 T4417 T4416 punct ",",]
R3408 T4418 T4420 nmod [,]
R3409 T4419 T4420 nummod 12,]
R3410 T4420 T4416 appos ],]
R3411 T4421 T4401 punct .,contribute
R3412 T4422 T4423 det This,process
R3413 T4423 T4436 nsubj process,allows
R3414 T4424 T4423 punct ",",process
R3415 T4425 T4423 acl known,process
R3416 T4426 T4425 prep as,known
R3417 T4427 T4429 amod immunoglobulin,switching
R3418 T4428 T4429 compound class,switching
R3419 T4429 T4426 pobj switching,as
R3420 T4430 T4429 punct (,switching
R3421 T4431 T4429 cc or,switching
R3422 T4432 T4433 compound isotype,switching
R3423 T4433 T4429 conj switching,switching
R3424 T4434 T4423 punct ),process
R3425 T4435 T4436 punct ",",allows
R3426 T4436 T4436 ROOT allows,allows
R3427 T4437 T4438 compound B,cells
R3428 T4438 T4436 dobj cells,allows
R3429 T4439 T4436 punct ",",allows
R3430 T4440 T4441 advmod initially,expressing
R3431 T4441 T4436 advcl expressing,allows
R3432 T4442 T4441 dobj IgM,expressing
R3433 T4443 T4436 punct ",",allows
R3434 T4444 T4445 aux to,switch
R3435 T4445 T4436 advcl switch,allows
R3436 T4446 T4445 prep to,switch
R3437 T4447 T4446 pobj IgA,to
R3438 T4448 T4447 punct ",",IgA
R3439 T4449 T4447 conj IgG,IgA
R3440 T4450 T4449 punct ",",IgG
R3441 T4451 T4449 cc or,IgG
R3442 T4452 T4449 conj IgE,IgG
R3443 T4453 T4445 prep depending,switch
R3444 T4454 T4453 prep on,depending
R3445 T4455 T4456 det the,class
R3446 T4456 T4454 pobj class,on
R3447 T4457 T4456 prep of,class
R3448 T4458 T4457 pobj antibody,of
R3449 T4459 T4460 advmod most,appropriate
R3450 T4460 T4456 amod appropriate,class
R3451 T4461 T4460 prep for,appropriate
R3452 T4462 T4465 det a,response
R3453 T4463 T4465 amod particular,response
R3454 T4464 T4465 amod immune,response
R3455 T4465 T4461 pobj response,for
R3456 T4466 T4436 punct .,allows
R3457 T4467 T4472 nsubjpass Switching,induced
R3458 T4468 T4467 prep to,Switching
R3459 T4469 T4468 pobj IgE,to
R3460 T4470 T4472 aux can,induced
R3461 T4471 T4472 auxpass be,induced
R3462 T4472 T4472 ROOT induced,induced
R3463 T4473 T4472 agent by,induced
R3464 T4474 T4475 det the,combination
R3465 T4475 T4473 pobj combination,by
R3466 T4476 T4475 prep of,combination
R3467 T4477 T4480 nmod IL-4,signals
R3468 T4478 T4477 cc and,IL-4
R3469 T4479 T4480 amod CD40,signals
R3470 T4480 T4476 pobj signals,of
R3471 T4481 T4472 punct .,induced
R3472 T4482 T4484 det The,rearrangement
R3473 T4483 T4484 compound gene,rearrangement
R3474 T4484 T4490 nsubjpass rearrangement,preceded
R3475 T4485 T4484 amod necessary,rearrangement
R3476 T4486 T4485 prep for,necessary
R3477 T4487 T4488 amod IgE,production
R3478 T4488 T4486 pobj production,for
R3479 T4489 T4490 auxpass is,preceded
R3480 T4490 T4490 ROOT preceded,preceded
R3481 T4491 T4490 agent by,preceded
R3482 T4492 T4493 det the,production
R3483 T4493 T4491 pobj production,by
R3484 T4494 T4493 prep of,production
R3485 T4495 T4497 amod non-coding,transcripts
R3486 T4496 T4497 compound RNA,transcripts
R3487 T4497 T4494 pobj transcripts,of
R3488 T4498 T4497 prep from,transcripts
R3489 T4499 T4500 amod germline,sequences
R3490 T4500 T4498 pobj sequences,from
R3491 T4501 T4500 prep in,sequences
R3492 T4502 T4505 det the,chain
R3493 T4503 T4505 nmod IgE,chain
R3494 T4504 T4505 amod heavy,chain
R3495 T4505 T4501 pobj chain,in
R3496 T4506 T4491 pobj locus,by
R3497 T4507 T4509 nmod [,]
R3498 T4508 T4509 nummod 13,]
R3499 T4509 T4506 appos ],locus
R3500 T4510 T4490 punct .,preceded
R3501 T4511 T4512 aux To,determine
R3502 T4512 T4532 advcl determine,stimulated
R3503 T4513 T4516 mark whether,required
R3504 T4514 T4516 nsubjpass HOIP,required
R3505 T4515 T4516 auxpass is,required
R3506 T4516 T4512 ccomp required,determine
R3507 T4517 T4516 prep in,required
R3508 T4518 T4519 det the,initiation
R3509 T4519 T4517 pobj initiation,in
R3510 T4520 T4519 prep of,initiation
R3511 T4521 T4524 det the,process
R3512 T4522 T4524 compound class,process
R3513 T4523 T4524 compound switching,process
R3514 T4524 T4520 pobj process,of
R3515 T4525 T4532 punct ",",stimulated
R3516 T4526 T4530 det the,lines
R3517 T4527 T4530 amod relevant,lines
R3518 T4528 T4529 compound B,cell
R3519 T4529 T4530 compound cell,lines
R3520 T4530 T4532 nsubjpass lines,stimulated
R3521 T4531 T4532 auxpass were,stimulated
R3522 T4532 T4532 ROOT stimulated,stimulated
R3523 T4533 T4532 prep through,stimulated
R3524 T4534 T4533 pobj CD40,through
R3525 T4535 T4532 prep in,stimulated
R3526 T4536 T4537 det the,presence
R3527 T4537 T4535 pobj presence,in
R3528 T4538 T4537 prep of,presence
R3529 T4539 T4538 pobj IL-4,of
R3530 T4540 T4532 cc and,stimulated
R3531 T4541 T4532 conj tested,stimulated
R3532 T4542 T4541 prep for,tested
R3533 T4543 T4542 pobj production,for
R3534 T4544 T4543 prep of,production
R3535 T4545 T4546 compound germline,epsilon
R3536 T4546 T4544 pobj epsilon,of
R3537 T4547 T4548 punct (,GLε
R3538 T4548 T4546 appos GLε,epsilon
R3539 T4549 T4546 punct ),epsilon
R3540 T4550 T4542 pobj transcripts,for
R3541 T4551 T4552 punct (,Fig.
R3542 T4552 T4550 appos Fig.,transcripts
R3543 T4553 T4552 nummod 3,Fig.
R3544 T4554 T4552 punct ),Fig.
R3545 T4555 T4532 punct .,stimulated
R3546 T4556 T4558 amod Anti-CD40,stimulation
R3547 T4557 T4558 compound antibody,stimulation
R3548 T4558 T4564 nsubj stimulation,induced
R3549 T4559 T4558 advmod alone,stimulation
R3550 T4560 T4559 cc or,alone
R3551 T4561 T4559 conj together,alone
R3552 T4562 T4558 prep with,stimulation
R3553 T4563 T4562 pobj IL-4,with
R3554 T4564 T4564 ROOT induced,induced
R3555 T4565 T4566 compound GLε,transcription
R3556 T4566 T4564 dobj transcription,induced
R3557 T4567 T4566 prep in,transcription
R3558 T4568 T4572 amod parental,cells
R3559 T4569 T4572 compound A20,cells
R3560 T4570 T4571 compound .2,J
R3561 T4571 T4572 compound J,cells
R3562 T4572 T4567 pobj cells,in
R3563 T4573 T4574 mark as,expected
R3564 T4574 T4572 advcl expected,cells
R3565 T4575 T4564 punct .,induced
R3566 T4576 T4586 prep In,detected
R3567 T4577 T4576 pobj contrast,In
R3568 T4578 T4586 punct ",",detected
R3569 T4579 T4581 advmod only,levels
R3570 T4580 T4581 amod low,levels
R3571 T4581 T4586 nsubjpass levels,detected
R3572 T4582 T4581 prep of,levels
R3573 T4583 T4584 compound GLε,expression
R3574 T4584 T4582 pobj expression,of
R3575 T4585 T4586 auxpass were,detected
R3576 T4586 T4586 ROOT detected,detected
R3577 T4587 T4586 prep in,detected
R3578 T4588 T4589 amod HOIP-deficient,cells
R3579 T4589 T4587 pobj cells,in
R3580 T4590 T4586 conj stimulated,detected
R3581 T4591 T4590 prep with,stimulated
R3582 T4592 T4594 det either,antibody
R3583 T4593 T4594 amod anti-CD40,antibody
R3584 T4594 T4591 pobj antibody,with
R3585 T4595 T4594 advmod alone,antibody
R3586 T4596 T4594 cc or,antibody
R3587 T4597 T4594 conj anti-CD40,antibody
R3588 T4598 T4597 cc and,anti-CD40
R3589 T4599 T4597 conj IL-4,anti-CD40
R3590 T4600 T4586 punct .,detected
R3591 T4601 T4602 amod Normal,levels
R3592 T4602 T4607 nsubjpass levels,induced
R3593 T4603 T4602 prep of,levels
R3594 T4604 T4605 compound GLε,expression
R3595 T4605 T4603 pobj expression,of
R3596 T4606 T4607 auxpass were,induced
R3597 T4607 T4607 ROOT induced,induced
R3598 T4608 T4607 prep in,induced
R3599 T4609 T4610 amod HOIP-reconstituted,cells
R3600 T4610 T4608 pobj cells,in
R3601 T4611 T4607 conj stimulated,induced
R3602 T4612 T4611 prep with,stimulated
R3603 T4613 T4614 amod anti-CD40,antibody
R3604 T4614 T4612 pobj antibody,with
R3605 T4615 T4614 advmod alone,antibody
R3606 T4616 T4615 cc or,alone
R3607 T4617 T4618 advmod together,with
R3608 T4618 T4615 conj with,alone
R3609 T4619 T4618 pobj IL-4,with
R3610 T4620 T4607 punct .,induced
R3611 T4621 T4625 advmod Collectively,demonstrate
R3612 T4622 T4625 punct ",",demonstrate
R3613 T4623 T4624 det these,data
R3614 T4624 T4625 nsubj data,demonstrate
R3615 T4625 T4625 ROOT demonstrate,demonstrate
R3616 T4626 T4628 mark that,has
R3617 T4627 T4628 nsubj HOIP,has
R3618 T4628 T4625 ccomp has,demonstrate
R3619 T4629 T4631 det a,role
R3620 T4630 T4631 amod critical,role
R3621 T4631 T4628 dobj role,has
R3622 T4632 T4631 prep in,role
R3623 T4633 T4634 amod cellular,responses
R3624 T4634 T4632 pobj responses,in
R3625 T4635 T4634 prep to,responses
R3626 T4636 T4637 dep CD40,signaling
R3627 T4637 T4628 prep signaling,has
R3628 T4638 T4625 punct .,demonstrate
R12180 T15392 T15394 amod CD40-mediated,upregulation
R12181 T15393 T15394 compound CD80,upregulation
R12182 T15394 T15395 nsubj upregulation,is
R12183 T15395 T15395 ROOT is,is
R12184 T15396 T15395 acomp defective,is
R12185 T15397 T15396 prep in,defective
R12186 T15398 T15399 amod HOIP-deficient,cells
R12187 T15399 T15397 pobj cells,in
R12188 T15400 T15395 punct .,is
R12189 T15401 T15403 nsubjpass Cells,incubated
R12190 T15402 T15403 auxpass were,incubated
R12191 T15403 T15403 ROOT incubated,incubated
R12192 T15404 T15403 prep for,incubated
R12193 T15405 T15406 nummod 72,hrs
R12194 T15406 T15404 pobj hrs,for
R12195 T15407 T15403 prep with,incubated
R12196 T15408 T15411 det an,antibody
R12197 T15409 T15410 amod isotype,control
R12198 T15410 T15411 compound control,antibody
R12199 T15411 T15407 pobj antibody,with
R12200 T15412 T15413 punct (,left
R12201 T15413 T15403 advcl left,incubated
R12202 T15414 T15413 punct ),left
R12203 T15415 T15413 cc or,left
R12204 T15416 T15417 amod anti-CD40,antibody
R12205 T15417 T15403 conj antibody,incubated
R12206 T15418 T15419 punct (,right
R12207 T15419 T15417 parataxis right,antibody
R12208 T15420 T15419 punct ),right
R12209 T15421 T15403 cc and,incubated
R12210 T15422 T15423 advmod then,stained
R12211 T15423 T15403 conj stained,incubated
R12212 T15424 T15423 prep for,stained
R12213 T15425 T15424 pobj expression,for
R12214 T15426 T15425 prep of,expression
R12215 T15427 T15426 pobj CD80,of
R12216 T15428 T15429 punct (,filled
R12217 T15429 T15430 amod filled,profiles
R12218 T15430 T15431 nsubj profiles,indicate
R12219 T15431 T15423 ccomp indicate,stained
R12220 T15432 T15431 ccomp staining,indicate
R12221 T15433 T15432 prep with,staining
R12222 T15434 T15435 amod anti-CD80,antibody
R12223 T15435 T15433 pobj antibody,with
R12224 T15436 T15431 punct ;,indicate
R12225 T15437 T15438 amod open,profiles
R12226 T15438 T15440 nsubj profiles,staining
R12227 T15439 T15440 aux are,staining
R12228 T15440 T15403 conj staining,incubated
R12229 T15441 T15440 prep with,staining
R12230 T15442 T15445 det an,antibody
R12231 T15443 T15444 amod isotype,control
R12232 T15444 T15445 compound control,antibody
R12233 T15445 T15441 pobj antibody,with
R12234 T15446 T15440 punct ),staining
R12235 T15447 T15440 punct .,staining
R12236 T15448 T15464 nsubj Transduction,reversed
R12237 T15449 T15448 prep of,Transduction
R12238 T15450 T15451 det both,HOIP-deficient
R12239 T15451 T15449 pobj HOIP-deficient,of
R12240 T15452 T15451 punct (,HOIP-deficient
R12241 T15453 T15455 amod HOIP,/
R12242 T15454 T15455 punct -,/
R12243 T15455 T15455 ROOT /,/
R12244 T15456 T15455 punct -,/
R12245 T15457 T15455 punct ),/
R12246 T15458 T15464 nsubj clones,reversed
R12247 T15459 T15458 prep with,clones
R12248 T15460 T15461 det a,retrovirus
R12249 T15461 T15459 pobj retrovirus,with
R12250 T15462 T15461 acl encoding,retrovirus
R12251 T15463 T15464 nsubj FLAG-HOIP,reversed
R12252 T15464 T15464 ROOT reversed,reversed
R12253 T15465 T15467 amod defective,upregulation
R12254 T15466 T15467 compound CD80,upregulation
R12255 T15467 T15464 dobj upregulation,reversed
R12256 T15468 T15464 punct ",",reversed
R12257 T15469 T15470 mark while,transduction
R12258 T15470 T15464 advcl transduction,reversed
R12259 T15471 T15470 prep with,transduction
R12260 T15472 T15474 det an,vector
R12261 T15473 T15474 amod empty,vector
R12262 T15474 T15471 pobj vector,with
R12263 T15475 T15474 punct (,vector
R12264 T15476 T15474 appos pMIP,vector
R12265 T15477 T15474 punct ),vector
R12266 T15478 T15480 aux did,.
R12267 T15479 T15478 neg not,did
R12268 T15480 T15464 punct .,reversed
R12269 T15481 T15482 amod Similar,results
R12270 T15482 T15484 nsubjpass results,obtained
R12271 T15483 T15484 auxpass were,obtained
R12272 T15484 T15484 ROOT obtained,obtained
R12273 T15485 T15484 prep in,obtained
R12274 T15486 T15488 det a,experiment
R12275 T15487 T15488 amod second,experiment
R12276 T15488 T15485 pobj experiment,in
R12277 T15489 T15484 punct .,obtained
R12429 T15742 T15743 compound GLε,transcription
R12430 T15743 T15744 nsubj transcription,is
R12431 T15744 T15744 ROOT is,is
R12432 T15745 T15744 acomp defective,is
R12433 T15746 T15745 prep in,defective
R12434 T15747 T15749 amod CD40-stimulated,cells
R12435 T15748 T15749 amod HOIP-deficient,cells
R12436 T15749 T15746 pobj cells,in
R12437 T15750 T15744 punct .,is
R12438 T15751 T15753 nummod A20,J
R12439 T15752 T15753 nummod .2,J
R12440 T15753 T15756 nmod J,cells
R12441 T15754 T15753 cc and,J
R12442 T15755 T15753 conj HOIP-deficient,J
R12443 T15756 T15756 ROOT cells,cells
R12444 T15757 T15756 acl transduced,cells
R12445 T15758 T15757 prep with,transduced
R12446 T15759 T15762 det an,vector
R12447 T15760 T15762 amod empty,vector
R12448 T15761 T15762 compound retroviral,vector
R12449 T15762 T15758 pobj vector,with
R12450 T15763 T15762 punct (,vector
R12451 T15764 T15768 nummod A20,pMIP
R12452 T15765 T15768 nummod .2,pMIP
R12453 T15766 T15768 nmod J,pMIP
R12454 T15767 T15768 nummod +,pMIP
R12455 T15768 T15762 appos pMIP,vector
R12456 T15769 T15768 cc and,pMIP
R12457 T15770 T15768 conj HOIP,pMIP
R12458 T15771 T15762 punct -,vector
R12459 T15772 T15762 punct /,vector
R12460 T15773 T15762 punct -,vector
R12461 T15774 T15775 compound +,pMIP
R12462 T15775 T15762 appos pMIP,vector
R12463 T15776 T15775 punct ",",pMIP
R12464 T15777 T15775 advmod respectively,pMIP
R12465 T15778 T15775 punct ),pMIP
R12466 T15779 T15775 punct ",",pMIP
R12467 T15780 T15775 cc or,pMIP
R12468 T15781 T15782 amod HOIP-deficient,cells
R12469 T15782 T15775 conj cells,pMIP
R12470 T15783 T15762 acl transduced,vector
R12471 T15784 T15783 prep with,transduced
R12472 T15785 T15787 det a,retrovirus
R12473 T15786 T15787 amod HOIP-encoding,retrovirus
R12474 T15787 T15784 pobj retrovirus,with
R12475 T15788 T15797 punct (,cultured
R12476 T15789 T15793 punct HOIP,+
R12477 T15790 T15793 punct -,+
R12478 T15791 T15793 punct /,+
R12479 T15792 T15793 punct -,+
R12480 T15793 T15797 nsubjpass +,cultured
R12481 T15794 T15793 npadvmod HOIP,+
R12482 T15795 T15797 punct ),cultured
R12483 T15796 T15797 auxpass were,cultured
R12484 T15797 T15787 parataxis cultured,retrovirus
R12485 T15798 T15797 npadvmod overnight,cultured
R12486 T15799 T15797 prep with,cultured
R12487 T15800 T15801 amod agonistic,anti-CD40
R12488 T15801 T15799 pobj anti-CD40,with
R12489 T15802 T15801 cc or,anti-CD40
R12490 T15803 T15806 det an,antibody
R12491 T15804 T15806 nmod isotype,antibody
R12492 T15805 T15806 compound control,antibody
R12493 T15806 T15801 conj antibody,anti-CD40
R12494 T15807 T15806 punct (,antibody
R12495 T15808 T15806 parataxis iso,antibody
R12496 T15809 T15808 punct ),iso
R12497 T15810 T15806 punct ",",antibody
R12498 T15811 T15806 conj with,antibody
R12499 T15812 T15811 cc or,with
R12500 T15813 T15811 conj without,with
R12501 T15814 T15813 pobj IL-4,without
R12502 T15815 T15756 punct .,cells
R12503 T15816 T15818 nsubjpass RNA,isolated
R12504 T15817 T15818 auxpass was,isolated
R12505 T15818 T15818 ROOT isolated,isolated
R12506 T15819 T15818 prep from,isolated
R12507 T15820 T15821 det the,cells
R12508 T15821 T15819 pobj cells,from
R12509 T15822 T15818 punct ",",isolated
R12510 T15823 T15818 conj reverse-transcribed,isolated
R12511 T15824 T15823 punct ",",reverse-transcribed
R12512 T15825 T15823 cc and,reverse-transcribed
R12513 T15826 T15827 advmod then,subjected
R12514 T15827 T15823 conj subjected,reverse-transcribed
R12515 T15828 T15827 prep to,subjected
R12516 T15829 T15830 amod quantitative,PCR
R12517 T15830 T15828 pobj PCR,to
R12518 T15831 T15832 aux to,determine
R12519 T15832 T15827 advcl determine,subjected
R12520 T15833 T15832 dobj levels,determine
R12521 T15834 T15833 prep of,levels
R12522 T15835 T15836 compound GLε,transcripts
R12523 T15836 T15834 pobj transcripts,of
R12524 T15837 T15818 punct .,isolated
R12525 T15838 T15839 nsubj Results,were
R12526 T15839 T15839 ROOT were,were
R12527 T15840 T15839 acomp normalized,were
R12528 T15841 T15840 prep to,normalized
R12529 T15842 T15843 det the,levels
R12530 T15843 T15841 pobj levels,to
R12531 T15844 T15843 prep of,levels
R12532 T15845 T15846 amod Hprt1,transcripts
R12533 T15846 T15844 pobj transcripts,of
R12534 T15847 T15843 prep in,levels
R12535 T15848 T15849 det each,sample
R12536 T15849 T15847 pobj sample,in
R12537 T15850 T15839 punct .,were
R12538 T15851 T15852 nsubj Symbols,indicate
R12539 T15852 T15852 ROOT indicate,indicate
R12540 T15853 T15854 det the,values
R12541 T15854 T15852 dobj values,indicate
R12542 T15855 T15852 prep from,indicate
R12543 T15856 T15857 compound duplicate,cultures
R12544 T15857 T15855 pobj cultures,from
R12545 T15858 T15857 punct (,cultures
R12546 T15859 T15860 det a,line
R12547 T15860 T15861 nsubj line,indicates
R12548 T15861 T15852 ccomp indicates,indicate
R12549 T15862 T15863 det the,mean
R12550 T15863 T15861 dobj mean,indicates
R12551 T15864 T15863 prep of,mean
R12552 T15865 T15867 det the,values
R12553 T15866 T15867 nummod two,values
R12554 T15867 T15864 pobj values,of
R12555 T15868 T15861 punct ),indicates
R12556 T15869 T15852 punct .,indicate
R12557 T15870 T15871 amod Similar,results
R12558 T15871 T15873 nsubjpass results,obtained
R12559 T15872 T15873 auxpass were,obtained
R12560 T15873 T15873 ROOT obtained,obtained
R12561 T15874 T15873 prep in,obtained
R12562 T15875 T15877 det a,experiment
R12563 T15876 T15877 amod second,experiment
R12564 T15877 T15874 pobj experiment,in
R12565 T15878 T15874 cc and,in
R12566 T15879 T15874 conj in,in
R12567 T15880 T15882 det an,experiment
R12568 T15881 T15882 amod additional,experiment
R12569 T15882 T15879 pobj experiment,in
R12570 T15883 T15882 prep with,experiment
R12571 T15884 T15887 det a,clone
R12572 T15885 T15887 amod second,clone
R12573 T15886 T15887 amod HOIP-deficient,clone
R12574 T15887 T15883 pobj clone,with
R12575 T15888 T15873 punct .,obtained

GO-BP

Id Subject Object Predicate Lexical cue
T5069 88-101 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T5070 2355-2368 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T5071 171-191 http://purl.obolibrary.org/obo/GO_0033580 denotes cell surface protein
T5072 171-191 http://purl.obolibrary.org/obo/GO_0034394 denotes cell surface protein
T5073 171-191 http://purl.obolibrary.org/obo/GO_0033575 denotes cell surface protein
T5074 328-337 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T5075 2797-2806 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T5076 1475-1506 http://purl.obolibrary.org/obo/GO_0045911 denotes activation of DNA recombination
T5077 1489-1506 http://purl.obolibrary.org/obo/GO_0006310 denotes DNA recombination
T5078 1597-1612 http://purl.obolibrary.org/obo/GO_0045190 denotes class switching
T5079 1603-1624 http://purl.obolibrary.org/obo/GO_0045190 denotes switching (or isotype
T5080 1597-1624 http://purl.obolibrary.org/obo/GO_0048290 denotes class switching (or isotype
T5081 1597-1624 http://purl.obolibrary.org/obo/GO_0048292 denotes class switching (or isotype
T5082 1597-1624 http://purl.obolibrary.org/obo/GO_0048289 denotes class switching (or isotype
T5083 1597-1624 http://purl.obolibrary.org/obo/GO_0048291 denotes class switching (or isotype
T5084 1778-1793 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T5085 2770-2778 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T15595 1184-1196 http://purl.obolibrary.org/obo/GO_0009293 denotes Transduction
T15596 1318-1330 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T16041 2856-2869 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription

GO-MF

Id Subject Object Predicate Lexical cue
T5086 1514-1528 http://purl.obolibrary.org/obo/GO_0003823 denotes immunoglobulin
T5087 1582-1596 http://purl.obolibrary.org/obo/GO_0003823 denotes immunoglobulin
T5088 1735-1743 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T5089 2294-2302 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T5090 2525-2533 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T5091 2662-2670 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T5092 1849-1853 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T5093 2205-2209 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T5094 2338-2342 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T5095 2557-2561 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T5096 2694-2698 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T15597 976-984 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T15598 1005-1013 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T15599 1112-1120 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T15600 1173-1181 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T16042 3204-3212 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T16043 3236-3240 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4

GO-CC

Id Subject Object Predicate Lexical cue
T16044 2917-2922 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16045 2950-2955 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16046 3067-3072 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16047 3268-3273 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16048 3204-3212 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T16049 3204-3212 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T5097 126-131 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5098 222-227 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5099 247-252 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5100 464-469 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5101 604-609 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5102 687-692 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5103 764-769 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5104 1442-1447 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5105 1646-1651 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5106 2388-2393 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5107 2486-2491 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5108 2630-2635 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5109 171-183 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface
T5110 263-266 http://purl.obolibrary.org/obo/GO_0005680 denotes APC
T5111 1735-1743 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T5112 2294-2302 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T5113 2525-2533 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T5114 2662-2670 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T5115 1735-1743 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T5116 2294-2302 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T5117 2525-2533 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T5118 2662-2670 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T15601 913-918 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15602 976-984 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T15603 1005-1013 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T15604 1112-1120 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T15605 1173-1181 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T15606 976-984 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T15607 1005-1013 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T15608 1112-1120 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T15609 1173-1181 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody

sentences

Id Subject Object Predicate Lexical cue
T4245 0-101 Sentence denotes HOIP is required for CD40-mediated CD80 upregulation and activation of germline epsilon transcription
T4246 102-267 Sentence denotes Engagement of CD40 on B cells upregulates expression of CD80 [10], a cell surface protein that promotes activation of T cells interacting with B cells and other APC.
T4247 268-479 Sentence denotes To begin evaluating potential contributions of HOIP to CD40 signaling, we assayed the upregulation of CD80 induced by engagement of CD40 on parental A20.2J, HOIP-deficient, and HOIP-reconstituted cells (Fig. 2).
T4248 480-617 Sentence denotes Compared to the parental cell line, the CD40-stimulated upregulation of CD80 was dramatically reduced in all HOIP-deficient cells tested.
T4249 618-805 Sentence denotes In contrast, upregulation of CD80 was restored in HOIP-reconstituted cells, confirming that the defect in CD80 upregulation in the HOIP-deficient cells was due to the disruption of Rnf31.
T4250 1424-1558 Sentence denotes CD40 signals in B cells can also contribute to the activation of DNA recombination in the immunoglobulin heavy chain locus [11], [12].
T4251 1559-1794 Sentence denotes This process, known as immunoglobulin class switching (or isotype switching), allows B cells, initially expressing IgM, to switch to IgA, IgG, or IgE depending on the class of antibody most appropriate for a particular immune response.
T4252 1795-1871 Sentence denotes Switching to IgE can be induced by the combination of IL-4 and CD40 signals.
T4253 1872-2042 Sentence denotes The gene rearrangement necessary for IgE production is preceded by the production of non-coding RNA transcripts from germline sequences in the IgE heavy chain locus [13].
T4254 2043-2283 Sentence denotes To determine whether HOIP is required in the initiation of the class switching process, the relevant B cell lines were stimulated through CD40 in the presence of IL-4 and tested for production of germline epsilon (GLε) transcripts (Fig. 3).
T4255 2284-2406 Sentence denotes Anti-CD40 antibody stimulation alone or together with IL-4 induced GLε transcription in parental A20.2J cells as expected.
T4256 2407-2562 Sentence denotes In contrast, only low levels of GLε expression were detected in HOIP-deficient cells stimulated with either anti-CD40 antibody alone or anti-CD40 and IL-4.
T4257 2563-2699 Sentence denotes Normal levels of GLε expression were induced in HOIP-reconstituted cells stimulated with anti-CD40 antibody alone or together with IL-4.
T4258 2700-2807 Sentence denotes Collectively, these data demonstrate that HOIP has a critical role in cellular responses to CD40 signaling.
T15388 850-919 Sentence denotes CD40-mediated CD80 upregulation is defective in HOIP-deficient cells.
T15389 920-1183 Sentence denotes Cells were incubated for 72 hrs with an isotype control antibody (left) or anti-CD40 antibody (right) and then stained for expression of CD80 (filled profiles indicate staining with anti-CD80 antibody; open profiles are staining with an isotype control antibody).
T15390 1184-1367 Sentence denotes Transduction of both HOIP-deficient (HOIP-/-) clones with a retrovirus encoding FLAG-HOIP reversed defective CD80 upregulation, while transduction with an empty vector (pMIP) did not.
T15391 1368-1421 Sentence denotes Similar results were obtained in a second experiment.
T15736 2852-2923 Sentence denotes GLε transcription is defective in CD40-stimulated HOIP-deficient cells.
T15737 2924-3241 Sentence denotes A20.2J and HOIP-deficient cells transduced with an empty retroviral vector (A20.2J + pMIP and HOIP-/- + pMIP, respectively), or HOIP-deficient cells transduced with a HOIP-encoding retrovirus (HOIP-/- + HOIP) were cultured overnight with agonistic anti-CD40 or an isotype control antibody (iso), with or without IL-4.
T15738 3242-3374 Sentence denotes RNA was isolated from the cells, reverse-transcribed, and then subjected to quantitative PCR to determine levels of GLε transcripts.
T15739 3375-3449 Sentence denotes Results were normalized to the levels of Hprt1 transcripts in each sample.
T15740 3450-3548 Sentence denotes Symbols indicate the values from duplicate cultures (a line indicates the mean of the two values).
T15741 3549-3669 Sentence denotes Similar results were obtained in a second experiment and in an additional experiment with a second HOIP-deficient clone.
T62 0-101 Sentence denotes HOIP is required for CD40-mediated CD80 upregulation and activation of germline epsilon transcription
T63 102-267 Sentence denotes Engagement of CD40 on B cells upregulates expression of CD80 [10], a cell surface protein that promotes activation of T cells interacting with B cells and other APC.
T64 268-479 Sentence denotes To begin evaluating potential contributions of HOIP to CD40 signaling, we assayed the upregulation of CD80 induced by engagement of CD40 on parental A20.2J, HOIP-deficient, and HOIP-reconstituted cells (Fig. 2).
T65 480-617 Sentence denotes Compared to the parental cell line, the CD40-stimulated upregulation of CD80 was dramatically reduced in all HOIP-deficient cells tested.
T66 618-805 Sentence denotes In contrast, upregulation of CD80 was restored in HOIP-reconstituted cells, confirming that the defect in CD80 upregulation in the HOIP-deficient cells was due to the disruption of Rnf31.
T67 806-919 Sentence denotes 10.1371/journal.pone.0023061.g002 Figure 2 CD40-mediated CD80 upregulation is defective in HOIP-deficient cells.
T68 920-1183 Sentence denotes Cells were incubated for 72 hrs with an isotype control antibody (left) or anti-CD40 antibody (right) and then stained for expression of CD80 (filled profiles indicate staining with anti-CD80 antibody; open profiles are staining with an isotype control antibody).
T69 1184-1367 Sentence denotes Transduction of both HOIP-deficient (HOIP-/-) clones with a retrovirus encoding FLAG-HOIP reversed defective CD80 upregulation, while transduction with an empty vector (pMIP) did not.
T70 1368-1421 Sentence denotes Similar results were obtained in a second experiment.
T71 1424-1558 Sentence denotes CD40 signals in B cells can also contribute to the activation of DNA recombination in the immunoglobulin heavy chain locus [11], [12].
T72 1559-1794 Sentence denotes This process, known as immunoglobulin class switching (or isotype switching), allows B cells, initially expressing IgM, to switch to IgA, IgG, or IgE depending on the class of antibody most appropriate for a particular immune response.
T73 1795-1871 Sentence denotes Switching to IgE can be induced by the combination of IL-4 and CD40 signals.
T74 1872-2042 Sentence denotes The gene rearrangement necessary for IgE production is preceded by the production of non-coding RNA transcripts from germline sequences in the IgE heavy chain locus [13].
T75 2043-2283 Sentence denotes To determine whether HOIP is required in the initiation of the class switching process, the relevant B cell lines were stimulated through CD40 in the presence of IL-4 and tested for production of germline epsilon (GLε) transcripts (Fig. 3).
T76 2284-2406 Sentence denotes Anti-CD40 antibody stimulation alone or together with IL-4 induced GLε transcription in parental A20.2J cells as expected.
T77 2407-2562 Sentence denotes In contrast, only low levels of GLε expression were detected in HOIP-deficient cells stimulated with either anti-CD40 antibody alone or anti-CD40 and IL-4.
T78 2563-2699 Sentence denotes Normal levels of GLε expression were induced in HOIP-reconstituted cells stimulated with anti-CD40 antibody alone or together with IL-4.
T79 2700-2807 Sentence denotes Collectively, these data demonstrate that HOIP has a critical role in cellular responses to CD40 signaling.
T80 2808-2923 Sentence denotes 10.1371/journal.pone.0023061.g003 Figure 3 GLε transcription is defective in CD40-stimulated HOIP-deficient cells.
T81 2924-3241 Sentence denotes A20.2J and HOIP-deficient cells transduced with an empty retroviral vector (A20.2J + pMIP and HOIP-/- + pMIP, respectively), or HOIP-deficient cells transduced with a HOIP-encoding retrovirus (HOIP-/- + HOIP) were cultured overnight with agonistic anti-CD40 or an isotype control antibody (iso), with or without IL-4.
T82 3242-3374 Sentence denotes RNA was isolated from the cells, reverse-transcribed, and then subjected to quantitative PCR to determine levels of GLε transcripts.
T83 3375-3449 Sentence denotes Results were normalized to the levels of Hprt1 transcripts in each sample.
T84 3450-3548 Sentence denotes Symbols indicate the values from duplicate cultures (a line indicates the mean of the two values).
T85 3549-3669 Sentence denotes Similar results were obtained in a second experiment and in an additional experiment with a second HOIP-deficient clone.

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T5002 0-4 Q96EP0 denotes HOIP
T5003 21-25 P25942 denotes CD40
T5004 35-39 P33681 denotes CD80
T5005 71-87 Q28322 denotes germline epsilon
T5006 116-120 P25942 denotes CD40
T5007 158-162 P33681 denotes CD80
T5008 315-319 Q96EP0 denotes HOIP
T5009 323-327 P25942 denotes CD40
T5010 370-374 P33681 denotes CD80
T5011 400-404 P25942 denotes CD40
T5012 417-420 P21580 denotes A20
T5013 425-429 Q96EP0 denotes HOIP
T5014 445-449 Q96EP0 denotes HOIP
T5015 520-524 P25942 denotes CD40
T5016 552-556 P33681 denotes CD80
T5017 589-593 Q96EP0 denotes HOIP
T5018 647-651 P33681 denotes CD80
T5019 668-672 Q96EP0 denotes HOIP
T5020 724-728 P33681 denotes CD80
T5021 749-753 Q96EP0 denotes HOIP
T5022 799-804 Q96EP0 denotes Rnf31
T5023 1424-1428 P25942 denotes CD40
T5024 1514-1540 P01860 denotes immunoglobulin heavy chain
T5025 1514-1540 P01877 denotes immunoglobulin heavy chain
T5026 1514-1540 P01871 denotes immunoglobulin heavy chain
T5027 1514-1540 P01876 denotes immunoglobulin heavy chain
T5028 1514-1540 P01859 denotes immunoglobulin heavy chain
T5029 1514-1540 P01861 denotes immunoglobulin heavy chain
T5030 1514-1540 P01854 denotes immunoglobulin heavy chain
T5031 1514-1540 P01857 denotes immunoglobulin heavy chain
T5032 1514-1540 P01880 denotes immunoglobulin heavy chain
T5033 1849-1853 P05112 denotes IL-4
T5034 1858-1862 P25942 denotes CD40
T5035 2064-2068 Q96EP0 denotes HOIP
T5036 2181-2185 P25942 denotes CD40
T5037 2205-2209 P05112 denotes IL-4
T5038 2239-2255 Q28322 denotes germline epsilon
T5039 2257-2260 Q28322 denotes GLε
T5040 2289-2293 P25942 denotes CD40
T5041 2338-2342 P05112 denotes IL-4
T5042 2351-2354 Q28322 denotes GLε
T5043 2381-2384 P21580 denotes A20
T5044 2439-2442 Q28322 denotes GLε
T5045 2471-2475 Q96EP0 denotes HOIP
T5046 2520-2524 P25942 denotes CD40
T5047 2548-2552 P25942 denotes CD40
T5048 2557-2561 P05112 denotes IL-4
T5049 2580-2583 Q28322 denotes GLε
T5050 2611-2615 Q96EP0 denotes HOIP
T5051 2657-2661 P25942 denotes CD40
T5052 2694-2698 P05112 denotes IL-4
T5053 2742-2746 Q96EP0 denotes HOIP
T5054 2792-2796 P25942 denotes CD40
T15581 850-854 P25942 denotes CD40
T15582 864-868 P33681 denotes CD80
T15583 898-902 Q96EP0 denotes HOIP
T15584 1000-1004 P25942 denotes CD40
T15585 1057-1061 P33681 denotes CD80
T15586 1107-1111 P33681 denotes CD80
T15587 1205-1209 Q96EP0 denotes HOIP
T15588 1221-1225 Q96EP0 denotes HOIP
T15589 1269-1273 Q96EP0 denotes HOIP
T15590 1293-1297 P33681 denotes CD80
T16020 2852-2855 Q28322 denotes GLε
T16021 2886-2890 P25942 denotes CD40
T16022 2902-2906 Q96EP0 denotes HOIP
T16023 2924-2927 P21580 denotes A20
T16024 2935-2939 Q96EP0 denotes HOIP
T16025 3000-3003 P21580 denotes A20
T16026 3018-3022 Q96EP0 denotes HOIP
T16027 3052-3056 Q96EP0 denotes HOIP
T16028 3091-3095 Q96EP0 denotes HOIP
T16029 3117-3121 Q96EP0 denotes HOIP
T16030 3127-3131 Q96EP0 denotes HOIP
T16031 3177-3181 P25942 denotes CD40
T16032 3236-3240 P05112 denotes IL-4
T16033 3358-3361 Q28322 denotes GLε
T16034 3648-3652 Q96EP0 denotes HOIP

test2

Id Subject Object Predicate Lexical cue Speculation
T4105 0-4 Protein denotes HOIP
T4106 8-16 Positive_regulation denotes required
T4107 21-25 Protein denotes CD40
T4108 26-34 Positive_regulation denotes mediated
T4109 35-39 Protein denotes CD80
T4110 40-52 Positive_regulation denotes upregulation
T4111 71-87 Protein denotes germline epsilon
T4112 102-112 Binding denotes Engagement
T4113 116-120 Protein denotes CD40
T4114 132-143 Positive_regulation denotes upregulates
T4115 144-154 Gene_expression denotes expression
T4116 158-162 Protein denotes CD80 true
T4117 315-319 Protein denotes HOIP
T4118 323-327 Protein denotes CD40
T4119 354-366 Positive_regulation denotes upregulation
T4120 370-374 Protein denotes CD80
T4121 375-382 Positive_regulation denotes induced
T4122 386-396 Binding denotes engagement
T4123 400-404 Protein denotes CD40
T4124 425-429 Protein denotes HOIP
T4125 430-439 Negative_regulation denotes deficient
T4126 445-449 Protein denotes HOIP
T4127 450-463 Positive_regulation denotes reconstituted
T4128 520-524 Protein denotes CD40
T4129 525-535 Positive_regulation denotes stimulated
T4130 536-548 Positive_regulation denotes upregulation true
T4131 552-556 Protein denotes CD80
T4132 574-581 Negative_regulation denotes reduced
T4133 589-593 Protein denotes HOIP
T4134 594-603 Negative_regulation denotes deficient
T4135 631-643 Positive_regulation denotes upregulation
T4136 647-651 Protein denotes CD80
T4137 668-672 Protein denotes HOIP
T4138 673-686 Positive_regulation denotes reconstituted
T4139 714-720 Negative_regulation denotes defect
T4140 724-728 Protein denotes CD80
T4141 729-741 Positive_regulation denotes upregulation
T4142 749-753 Protein denotes HOIP
T4143 754-763 Negative_regulation denotes deficient
T4144 774-777 Positive_regulation denotes due
T4145 785-795 Negative_regulation denotes disruption
T4146 799-804 Protein denotes Rnf31
T4147 1424-1428 Protein denotes CD40
T4148 1819-1826 Positive_regulation denotes induced
T4149 1849-1853 Protein denotes IL-4
T4150 1858-1862 Protein denotes CD40
T4151 2064-2068 Protein denotes HOIP
T4152 2181-2185 Protein denotes CD40
T4153 2205-2209 Protein denotes IL-4
T4154 2225-2235 Gene_expression denotes production
T4155 2239-2255 Protein denotes germline epsilon
T4156 2257-2260 Protein denotes GLε
T4157 2338-2342 Protein denotes IL-4
T4158 2343-2350 Positive_regulation denotes induced
T4159 2351-2354 Protein denotes GLε
T4160 2355-2368 Transcription denotes transcription
T4161 2439-2442 Protein denotes GLε
T4162 2443-2453 Gene_expression denotes expression
T4163 2471-2475 Protein denotes HOIP
T4164 2476-2485 Negative_regulation denotes deficient
T4165 2557-2561 Protein denotes IL-4
T4166 2580-2583 Protein denotes GLε
T4167 2584-2594 Gene_expression denotes expression
T4168 2600-2607 Positive_regulation denotes induced
T4169 2611-2615 Protein denotes HOIP
T4170 2616-2629 Positive_regulation denotes reconstituted
T4171 2694-2698 Protein denotes IL-4
T4172 2742-2746 Protein denotes HOIP
T4173 2792-2796 Protein denotes CD40
T15355 850-854 Protein denotes CD40
T15356 855-863 Positive_regulation denotes mediated
T15357 864-868 Protein denotes CD80
T15358 869-881 Positive_regulation denotes upregulation
T15359 885-894 Negative_regulation denotes defective true
T15360 898-902 Protein denotes HOIP
T15361 903-912 Negative_regulation denotes deficient
T15362 1043-1053 Gene_expression denotes expression
T15363 1057-1061 Protein denotes CD80
T15364 1205-1209 Protein denotes HOIP
T15365 1210-1219 Negative_regulation denotes deficient
T15366 1221-1225 Protein denotes HOIP
T15367 1269-1273 Protein denotes HOIP
T15368 1283-1292 Negative_regulation denotes defective
T15369 1293-1297 Protein denotes CD80
T15370 1298-1310 Positive_regulation denotes upregulation
T15696 2852-2855 Protein denotes GLε
T15697 2856-2869 Transcription denotes transcription
T15698 2886-2890 Protein denotes CD40
T15699 2902-2906 Protein denotes HOIP
T15700 2907-2916 Negative_regulation denotes deficient
T15701 2935-2939 Protein denotes HOIP true
T15702 2940-2949 Negative_regulation denotes deficient
T15703 3018-3022 Protein denotes HOIP
T15704 3052-3056 Protein denotes HOIP
T15705 3057-3066 Negative_regulation denotes deficient
T15706 3091-3095 Protein denotes HOIP
T15707 3117-3121 Protein denotes HOIP
T15708 3127-3131 Protein denotes HOIP
T15709 3236-3240 Protein denotes IL-4
T15710 3358-3361 Protein denotes GLε
T15711 3416-3421 Protein denotes Hprt1
T15712 3422-3433 Transcription denotes transcripts
T15713 3648-3652 Protein denotes HOIP
T15714 3653-3662 Negative_regulation denotes deficient
R3163 T4105 T4106 causeOf HOIP,required
R3164 T4107 T4108 causeOf CD40,mediated
R3165 T4108 T4106 themeOf mediated,required
R3166 T4109 T4110 themeOf CD80,upregulation
R3167 T4110 T4108 themeOf upregulation,mediated
R3168 T4112 T4114 causeOf Engagement,upregulates
R3169 T4113 T4112 themeOf CD40,Engagement
R3170 T4115 T4114 themeOf expression,upregulates
R3171 T4116 T4115 themeOf CD80,expression
R3172 T4119 T4121 themeOf upregulation,induced
R3173 T4120 T4119 themeOf CD80,upregulation
R3174 T4122 T4121 causeOf engagement,induced
R3175 T4123 T4122 themeOf CD40,engagement
R3176 T4124 T4125 themeOf HOIP,deficient
R3177 T4126 T4127 themeOf HOIP,reconstituted
R3178 T4128 T4129 causeOf CD40,stimulated
R3179 T4129 T4132 themeOf stimulated,reduced
R3180 T4130 T4129 themeOf upregulation,stimulated
R3181 T4130 T4132 themeOf upregulation,reduced
R3182 T4131 T4130 themeOf CD80,upregulation
R3183 T4133 T4134 themeOf HOIP,deficient
R3184 T4134 T4132 causeOf deficient,reduced
R3185 T4136 T4135 themeOf CD80,upregulation
R3186 T4137 T4138 themeOf HOIP,reconstituted
R3187 T4139 T4144 themeOf defect,due
R3188 T4140 T4141 themeOf CD80,upregulation
R3189 T4141 T4144 themeOf upregulation,due
R3190 T4141 T4139 themeOf upregulation,defect
R3191 T4142 T4143 themeOf HOIP,deficient
R3192 T4143 T4139 causeOf deficient,defect
R3193 T4145 T4144 causeOf disruption,due
R3194 T4145 T4139 causeOf disruption,defect
R3195 T4146 T4145 themeOf Rnf31,disruption
R3196 T4155 T4154 themeOf germline epsilon,production
R3197 T4156 T4155 equivalentTo GLε,germline epsilon
R3198 T4157 T4158 causeOf IL-4,induced
R3199 T4159 T4160 themeOf GLε,transcription
R3200 T4160 T4158 themeOf transcription,induced
R3201 T4161 T4162 themeOf GLε,expression
R3202 T4163 T4164 themeOf HOIP,deficient
R3203 T4166 T4167 themeOf GLε,expression
R3204 T4167 T4168 themeOf expression,induced
R3205 T4169 T4170 themeOf HOIP,reconstituted
R3206 T4170 T4168 causeOf reconstituted,induced
R12159 T15355 T15356 causeOf CD40,mediated
R12160 T15356 T15359 themeOf mediated,defective
R12161 T15357 T15358 themeOf CD80,upregulation
R12162 T15358 T15356 themeOf upregulation,mediated
R12163 T15358 T15359 themeOf upregulation,defective
R12164 T15360 T15361 themeOf HOIP,deficient
R12165 T15361 T15359 causeOf deficient,defective
R12166 T15363 T15362 themeOf CD80,expression
R12167 T15364 T15365 themeOf HOIP,deficient
R12168 T15369 T15370 themeOf CD80,upregulation
R12169 T15370 T15368 themeOf upregulation,defective
R12415 T15696 T15697 themeOf GLε,transcription
R12416 T15699 T15700 themeOf HOIP,deficient
R12417 T15701 T15702 themeOf HOIP,deficient
R12418 T15704 T15705 themeOf HOIP,deficient
R12419 T15711 T15712 themeOf Hprt1,transcripts
R12420 T15713 T15714 themeOf HOIP,deficient