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PMC:3148254 / 22085-27684 JSONTXT

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bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Speculation
T9062 49-53 Protein denotes HOIP
T9063 70-74 Protein denotes CD40
T9064 141-145 Protein denotes HOIP
T9065 146-155 Regulation denotes dependent
T9066 183-187 Protein denotes CD40
T9067 188-196 Positive_regulation denotes mediated
T9068 197-209 Positive_regulation denotes upregulation
T9069 213-217 Protein denotes CD80
T9070 218-228 Gene_expression denotes expression
T9071 448-452 Protein denotes HOIP
T9072 463-473 Regulation denotes downstream
T9073 477-482 Protein denotes TRAF2
T9074 490-494 Protein denotes CD40
T9075 522-526 Protein denotes HOIP
T9076 537-541 Regulation denotes role
T9077 545-554 Positive_regulation denotes promoting
T9078 559-570 Binding denotes recruitment
T9079 593-597 Protein denotes CD40
T9080 621-625 Protein denotes CD40
T9081 724-728 Protein denotes HOIP
T9082 778-782 Protein denotes CD40
T9083 783-793 Binding denotes engagement
T9084 858-862 Protein denotes HOIP
T9085 889-893 Protein denotes CD40
T9086 937-941 Protein denotes CD40
T9087 1025-1029 Protein denotes HOIP
T9088 1119-1123 Protein denotes HOIP
T9089 1192-1196 Protein denotes HOIP
T9090 1221-1227 Protein denotes HOIL-1
T9091 1399-1407 Binding denotes interact
T9092 1413-1417 Protein denotes IKKγ
T9093 1567-1575 Positive_regulation denotes mediates
T9094 1576-1587 Binding denotes recruitment
T9095 1591-1595 Protein denotes IKKγ
T9096 1640-1644 Protein denotes CD40
T9097 1645-1655 Binding denotes associated
T9098 1656-1660 Protein denotes HOIP
T9099 1674-1678 Regulation denotes role
T9100 1682-1692 Positive_regulation denotes activating
T9101 1693-1697 Protein denotes IKKγ
T9102 1708-1719 Binding denotes recruitment
T9103 1788-1792 Protein denotes IKKγ
T9104 1808-1812 Protein denotes CD40
T9105 1918-1933 Phosphorylation denotes phosphorylation true
T9106 1938-1952 Ubiquitination denotes ubiquitination true
T9107 1983-1989 Negative_regulation denotes reduce
T9108 1983-1989 Negative_regulation denotes reduce
T9109 1993-2000 Positive_regulation denotes enhance
T9110 1993-2000 Positive_regulation denotes enhance
T9111 2001-2005 Protein denotes IKKγ
T9112 2065-2069 Protein denotes HOIP
T9113 2070-2078 Positive_regulation denotes mediates
T9114 2079-2090 Binding denotes recruitment
T9115 2113-2117 Protein denotes CD40
T9116 2131-2135 Protein denotes HOIP
T9117 2139-2148 Binding denotes recruited
T9118 2152-2156 Protein denotes CD40
T9119 2205-2209 Protein denotes HOIP
T9120 2284-2307 Positive_regulation denotes functions as an adaptor
T9121 2316-2327 Binding denotes recruitment
T9122 2350-2354 Protein denotes CD40
T9123 2398-2402 Protein denotes HOIP
T9124 2463-2467 Protein denotes IKKγ
T9125 2487-2494 Binding denotes binding true
T9126 2548-2552 Protein denotes HOIP
T9127 2659-2664 Positive_regulation denotes serve
T9128 2668-2675 Binding denotes recruit
T9129 2676-2680 Protein denotes IKKγ
T9130 2739-2748 Positive_regulation denotes necessary
T9131 2753-2764 Binding denotes recruitment
T9132 2768-2772 Protein denotes HOIP
T9133 2879-2890 Binding denotes recruitment
T9134 2894-2898 Protein denotes HOIP
T9135 2927-2932 Protein denotes TRAF2
T9136 2933-2942 Regulation denotes dependent
T9137 2961-2966 Protein denotes TRAF2
T9138 2971-2975 Protein denotes HOIP
T9139 2985-2993 Binding denotes interact
T9140 3052-3057 Protein denotes TRAF2
T9141 3169-3173 Protein denotes HOIP
T9142 3178-3182 Binding denotes bind
T9143 3192-3201 Binding denotes associate
T9144 3311-3316 Protein denotes TRAF2
T9145 3321-3325 Protein denotes HOIP
T9146 3329-3333 Protein denotes CD40
T9147 3402-3407 Protein denotes TRAF6
T9148 3419-3424 Protein denotes TRAF2
T9149 3525-3529 Protein denotes CD40
T9150 3558-3563 Protein denotes TRAF2
T9151 3567-3572 Protein denotes TRAF6
T9152 3601-3605 Protein denotes CD40
T9153 3631-3636 Protein denotes TRAF6
T9154 3648-3652 Protein denotes HOIP
T9155 3653-3663 Negative_regulation denotes deficiency
T9156 3680-3684 Protein denotes CD40
T9157 3769-3774 Protein denotes TRAF2
T9158 3779-3784 Protein denotes TRAF6
T9159 3805-3809 Protein denotes HOIP
T9160 3856-3860 Protein denotes CD40
T9161 3905-3910 Protein denotes TRAF6
T9162 3949-3959 Negative_regulation denotes disruption
T9163 3967-3979 Entity denotes binding site
T9164 3984-3989 Protein denotes TRAF6
T9165 4019-4023 Protein denotes CD40
T9166 4027-4035 Negative_regulation denotes deletion
T9167 4043-4066 Entity denotes receptor binding domain
T9168 4090-4095 Protein denotes TRAF6
T9169 4134-4139 Protein denotes TRAF6
T9170 4158-4162 Binding denotes bind
T9171 4163-4167 Protein denotes CD40
T9172 4351-4358 Negative_regulation denotes absence
T9173 4362-4366 Protein denotes HOIP
T9174 4450-4454 Protein denotes CD40
T9175 4534-4538 Protein denotes HOIP
T9176 4588-4593 Protein denotes TRAF2
T9177 4597-4602 Protein denotes TRAF6
T9178 4754-4758 Protein denotes HOIP
T9179 4854-4858 Protein denotes HOIP
T9180 4859-4868 Binding denotes interacts
T9181 4893-4900 Protein denotes SHARPIN
T9182 4902-4972 Protein denotes SHANK-associated RH domain interacting protein in postsynaptic density
T9183 5022-5026 Protein denotes HOIP
T9184 5031-5035 Protein denotes HOIL
T9185 5171-5178 Protein denotes SHARPIN
T9186 5453-5457 Binding denotes link
T9187 5466-5473 Protein denotes SHARPIN
T9188 5478-5482 Protein denotes HOIP
T9189 5553-5560 Negative_regulation denotes defects true
T9190 5568-5578 Regulation denotes regulation
T9191 5594-5598 Protein denotes HOIP
R6967 T9064 T9065 causeOf HOIP,dependent
R6968 T9066 T9067 causeOf CD40,mediated
R6969 T9067 T9065 themeOf mediated,dependent
R6970 T9068 T9067 themeOf upregulation,mediated
R6971 T9069 T9070 themeOf CD80,expression
R6972 T9070 T9068 themeOf expression,upregulation
R6973 T9071 T9072 themeOf HOIP,downstream
R6974 T9073 T9072 causeOf TRAF2,downstream
R6975 T9075 T9076 causeOf HOIP,role
R6976 T9077 T9076 themeOf promoting,role
R6977 T9078 T9077 themeOf recruitment,promoting
R6978 T9079 T9078 themeOf CD40,recruitment
R6979 T9082 T9083 themeOf CD40,engagement
R6980 T9092 T9091 themeOf IKKγ,interact
R6981 T9094 T9093 themeOf recruitment,mediates
R6982 T9095 T9094 themeOf IKKγ,recruitment
R6983 T9096 T9097 themeOf CD40,associated
R6984 T9098 T9097 themeOf HOIP,associated
R6985 T9098 T9099 causeOf HOIP,role
R6986 T9098 T9102 themeOf HOIP,recruitment
R6987 T9100 T9099 themeOf activating,role
R6988 T9101 T9100 themeOf IKKγ,activating
R6989 T9103 T9106 themeOf IKKγ,ubiquitination
R6990 T9103 T9105 themeOf IKKγ,phosphorylation
R6991 T9105 T9107 causeOf phosphorylation,reduce
R6992 T9105 T9110 causeOf phosphorylation,enhance
R6993 T9106 T9108 causeOf ubiquitination,reduce
R6994 T9106 T9109 causeOf ubiquitination,enhance
R6995 T9111 T9107 themeOf IKKγ,reduce
R6996 T9111 T9108 themeOf IKKγ,reduce
R6997 T9111 T9110 themeOf IKKγ,enhance
R6998 T9111 T9109 themeOf IKKγ,enhance
R6999 T9112 T9113 causeOf HOIP,mediates
R7000 T9114 T9113 themeOf recruitment,mediates
R7001 T9115 T9114 themeOf CD40,recruitment
R7002 T9116 T9117 themeOf HOIP,recruited
R7003 T9118 T9117 themeOf CD40,recruited
R7004 T9119 T9120 causeOf HOIP,functions as an adaptor
R7005 T9121 T9120 themeOf recruitment,functions as an adaptor
R7006 T9122 T9121 themeOf CD40,recruitment
R7007 T9124 T9125 themeOf IKKγ,binding
R7008 T9128 T9127 themeOf recruit,serve
R7009 T9129 T9128 themeOf IKKγ,recruit
R7010 T9131 T9130 themeOf recruitment,necessary
R7011 T9132 T9131 themeOf HOIP,recruitment
R7012 T9133 T9136 themeOf recruitment,dependent
R7013 T9134 T9133 themeOf HOIP,recruitment
R7014 T9135 T9136 causeOf TRAF2,dependent
R7015 T9137 T9139 themeOf TRAF2,interact
R7016 T9138 T9139 themeOf HOIP,interact
R7017 T9141 T9142 themeOf HOIP,bind
R7018 T9141 T9143 themeOf HOIP,associate
R7019 T9154 T9155 themeOf HOIP,deficiency
R7020 T9163 T9162 themeOf binding site,disruption
R7021 T9163 T9165 partOf binding site,CD40
R7022 T9167 T9166 themeOf receptor binding domain,deletion
R7023 T9167 T9168 partOf receptor binding domain,TRAF6
R7024 T9169 T9170 themeOf TRAF6,bind
R7025 T9171 T9170 themeOf CD40,bind
R7026 T9173 T9172 themeOf HOIP,absence
R7027 T9179 T9180 themeOf HOIP,interacts
R7028 T9181 T9180 themeOf SHARPIN,interacts
R7029 T9182 T9181 equivalentTo SHANK-associated RH domain interacting protein in postsynaptic density,SHARPIN
R7030 T9187 T9186 themeOf SHARPIN,link
R7031 T9188 T9186 themeOf HOIP,link
R7032 T9190 T9189 themeOf regulation,defects
R7033 T9191 T9190 themeOf HOIP,regulation

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T11648 70-74 Protein denotes CD40
T11649 183-187 Protein denotes CD40
T11650 213-217 Protein denotes CD80
T11651 280-312 Protein denotes immunoglobulin heavy chain locus
T11652 218-228 Gene_expression denotes expression
T11653 197-209 Positive_regulation denotes upregulation
T11654 477-482 Protein denotes TRAF2
T11655 490-494 Protein denotes CD40
T11656 578-589 Protein denotes IKK complex
T11657 593-597 Protein denotes CD40
T11658 559-570 Binding denotes recruitment
T11659 545-554 Positive_regulation denotes promoting
T11660 621-625 Protein denotes CD40
T11661 648-653 Protein denotes NF-κB
T11662 634-644 Positive_regulation denotes activation
T11663 657-666 Positive_regulation denotes dependent
T11664 626-633 Positive_regulation denotes induced
T11665 634-644 Positive_regulation denotes activation
T11666 724-740 Protein denotes HOIP facilitates
T11667 759-762 Protein denotes JNK
T11668 778-793 Protein denotes CD40 engagement
T11669 745-755 Positive_regulation denotes activation
T11670 889-893 Protein denotes CD40
T11671 937-941 Protein denotes CD40
T11672 1119-1123 Protein denotes HOIP
T11673 1413-1417 Protein denotes IKKγ
T11674 1447-1452 Protein denotes NF-κB
T11675 1399-1407 Binding denotes interact
T11676 1433-1443 Positive_regulation denotes activation
T11677 1591-1595 Protein denotes IKKγ
T11678 1603-1607 Protein denotes CD40
T11679 1576-1587 Binding denotes recruitment
T11680 1567-1575 Positive_regulation denotes mediates
T11681 1640-1644 Protein denotes CD40
T11682 1788-1792 Protein denotes IKKγ
T11683 1808-1812 Protein denotes CD40
T11684 2001-2005 Protein denotes IKKγ
T11685 1813-1831 Binding denotes immunoprecipitates
T11686 1993-2000 Positive_regulation denotes enhance
T11687 2098-2109 Protein denotes IKK complex
T11688 2113-2117 Protein denotes CD40
T11689 2152-2156 Protein denotes CD40
T11690 2079-2090 Binding denotes recruitment
T11691 2139-2148 Binding denotes recruited
T11692 2070-2078 Positive_regulation denotes mediates
T11693 2205-2209 Protein denotes HOIP
T11694 2247-2250 Protein denotes IKK
T11695 2335-2346 Protein denotes IKK complex
T11696 2350-2354 Protein denotes CD40
T11697 2316-2327 Binding denotes recruitment
T11698 2369-2385 Protein denotes ubiquitin ligase
T11699 2463-2467 Protein denotes IKKγ
T11700 2607-2611 Protein denotes CD40
T11701 2676-2680 Protein denotes IKKγ
T11702 2688-2692 Protein denotes CD40
T11703 2487-2494 Binding denotes binding
T11704 2668-2675 Binding denotes recruit
T11705 2703-2710 Binding denotes complex
T11706 2787-2791 Protein denotes CD40
T11707 2753-2764 Binding denotes recruitment
T11708 2894-2898 Protein denotes HOIP
T11709 2927-2932 Protein denotes TRAF2
T11710 2879-2890 Binding denotes recruitment
T11711 2961-2966 Protein denotes TRAF2
T11712 2971-2993 Protein denotes HOIP directly interact
T11713 3023-3039 Protein denotes ubiquitin ligase
T11714 3067-3072 Protein denotes TRAF2
T11715 3139-3159 Protein denotes polyubiquitin chains
T11716 3211-3215 Protein denotes CD40
T11717 3118-3127 Binding denotes generates
T11718 3178-3182 Binding denotes bind
T11719 3192-3201 Binding denotes associate
T11720 3192-3201 Binding denotes associate
T11721 3311-3316 Protein denotes TRAF2
T11722 3321-3325 Protein denotes HOIP
T11723 3329-3333 Protein denotes CD40
T11724 3402-3407 Protein denotes TRAF6
T11725 3419-3424 Protein denotes TRAF2
T11726 3298-3302 Binding denotes link
T11727 3387-3396 Positive_regulation denotes dependent
T11728 3387-3396 Positive_regulation denotes dependent
T11729 3455-3459 Protein denotes TRAF
T11730 3516-3521 Protein denotes NF-κB
T11731 3525-3529 Protein denotes CD40
T11732 3558-3563 Protein denotes TRAF2
T11733 3567-3572 Protein denotes TRAF6
T11734 3594-3597 Protein denotes JNK
T11735 3601-3605 Protein denotes CD40
T11736 3631-3636 Protein denotes TRAF6
T11737 3460-3469 Negative_regulation denotes deficient
T11738 3502-3512 Positive_regulation denotes activation
T11739 3539-3547 Positive_regulation denotes mediated
T11740 3539-3547 Positive_regulation denotes mediated
T11741 3580-3590 Positive_regulation denotes activation
T11742 3618-3627 Positive_regulation denotes dependent
T11743 3680-3684 Protein denotes CD40
T11744 3713-3718 Protein denotes NF-κB
T11745 3723-3726 Protein denotes JNK
T11746 3769-3774 Protein denotes TRAF2
T11747 3779-3784 Protein denotes TRAF6
T11748 3694-3704 Positive_regulation denotes activation
T11749 3694-3704 Positive_regulation denotes activation
T11750 3685-3693 Positive_regulation denotes mediated
T11751 3685-3693 Positive_regulation denotes mediated
T11752 3856-3860 Protein denotes CD40
T11753 3884-3889 Protein denotes NF-κB
T11754 3894-3897 Protein denotes JNK
T11755 3905-3910 Protein denotes TRAF6
T11756 3984-3989 Protein denotes TRAF6
T11757 4019-4023 Protein denotes CD40
T11758 4090-4095 Protein denotes TRAF6
T11759 3870-3880 Positive_regulation denotes activation
T11760 3870-3880 Positive_regulation denotes activation
T11761 4134-4139 Protein denotes TRAF6
T11762 4163-4167 Protein denotes CD40
T11763 4158-4162 Binding denotes bind
T11764 4450-4454 Protein denotes CD40
T11765 4588-4593 Protein denotes TRAF2
T11766 4597-4602 Protein denotes TRAF6
T11767 4672-4696 Protein denotes TNF receptor superfamily
T11768 4705-4724 Protein denotes Toll-like receptors
T11769 4633-4643 Binding denotes associated
T11770 4754-4758 Protein denotes HOIP
T11771 4782-4793 Protein denotes TNFR family
T11772 4893-4900 Protein denotes SHARPIN
T11773 4902-4907 Protein denotes SHANK
T11774 4919-4921 Protein denotes RH
T11775 4859-4868 Binding denotes interacts
T11776 4859-4868 Binding denotes interacts
T11777 5171-5178 Protein denotes SHARPIN
T11778 5382-5396 Protein denotes immunoglobulin
T11779 5359-5369 Gene_expression denotes production
T11780 5466-5473 Protein denotes SHARPIN
T11781 5478-5482 Protein denotes HOIP
T11782 5594-5598 Protein denotes HOIP
T11783 5568-5578 Regulation denotes regulation
R9092 T11649 T11653 causeOf CD40,upregulation
R9099 T11650 T11652 themeOf CD80,expression
R9101 T11652 T11653 themeOf expression,upregulation
R9104 T11656 T11658 themeOf IKK complex,recruitment
R9105 T11657 T11658 themeOf CD40,recruitment
R9106 T11658 T11659 themeOf recruitment,promoting
R9108 T11660 T11664 causeOf CD40,induced
R9109 T11661 T11662 themeOf NF-κB,activation
R9110 T11662 T11663 themeOf activation,dependent
R9113 T11662 T11664 themeOf activation,induced
R9114 T11664 T11665 themeOf induced,activation
R9115 T11667 T11669 themeOf JNK,activation
R9116 T11673 T11675 themeOf IKKγ,interact
R9117 T11674 T11676 themeOf NF-κB,activation
R9118 T11708 T11710 themeOf HOIP,recruitment
R9119 T11677 T11679 themeOf IKKγ,recruitment
R9120 T11713 T11717 themeOf ubiquitin ligase,generates
R9121 T11678 T11679 themeOf CD40,recruitment
R9122 T11715 T11717 themeOf polyubiquitin chains,generates
R9123 T11715 T11718 themeOf polyubiquitin chains,bind
R9124 T11715 T11720 themeOf polyubiquitin chains,associate
R9125 T11716 T11719 themeOf CD40,associate
R9126 T11716 T11720 themeOf CD40,associate
R9127 T11679 T11680 themeOf recruitment,mediates
R9128 T11721 T11726 themeOf TRAF2,link
R9129 T11722 T11726 themeOf HOIP,link
R9130 T11682 T11685 themeOf IKKγ,immunoprecipitates
R9131 T11724 T11727 themeOf TRAF6,dependent
R9132 T11725 T11728 themeOf TRAF2,dependent
R9133 T11683 T11685 themeOf CD40,immunoprecipitates
R9134 T11729 T11737 themeOf TRAF,deficient
R9135 T11730 T11738 themeOf NF-κB,activation
R9136 T11684 T11686 themeOf IKKγ,enhance
R9137 T11731 T11738 causeOf CD40,activation
R9138 T11732 T11739 causeOf TRAF2,mediated
R9139 T11687 T11690 themeOf IKK complex,recruitment
R9140 T11733 T11740 causeOf TRAF6,mediated
R9141 T11734 T11741 themeOf JNK,activation
R9142 T11735 T11741 causeOf CD40,activation
R9143 T11736 T11742 causeOf TRAF6,dependent
R9144 T11738 T11739 themeOf activation,mediated
R9145 T11738 T11740 themeOf activation,mediated
R9146 T11688 T11690 themeOf CD40,recruitment
R9147 T11741 T11742 themeOf activation,dependent
R9148 T11689 T11691 themeOf CD40,recruited
R9149 T11743 T11750 causeOf CD40,mediated
R9150 T11743 T11751 causeOf CD40,mediated
R9151 T11744 T11748 themeOf NF-κB,activation
R9152 T11690 T11692 themeOf recruitment,mediates
R9153 T11745 T11749 themeOf JNK,activation
R9154 T11695 T11697 themeOf IKK complex,recruitment
R9155 T11748 T11750 themeOf activation,mediated
R9156 T11749 T11751 themeOf activation,mediated
R9157 T11696 T11697 themeOf CD40,recruitment
R9158 T11752 T11759 causeOf CD40,activation
R9159 T11752 T11760 causeOf CD40,activation
R9160 T11753 T11759 themeOf NF-κB,activation
R9161 T11699 T11703 themeOf IKKγ,binding
R9162 T11754 T11760 themeOf JNK,activation
R9163 T11701 T11704 themeOf IKKγ,recruit
R9164 T11761 T11763 themeOf TRAF6,bind
R9165 T11762 T11763 themeOf CD40,bind
R9166 T11702 T11705 themeOf CD40,complex
R9167 T11765 T11769 themeOf TRAF2,associated
R9168 T11706 T11707 themeOf CD40,recruitment
R9169 T11768 T11769 themeOf Toll-like receptors,associated
R9170 T11770 T11775 themeOf HOIP,interacts
R9171 T11770 T11776 themeOf HOIP,interacts
R9173 T11772 T11775 themeOf SHARPIN,interacts
R9174 T11774 T11776 themeOf RH,interacts
R9175 T11778 T11779 themeOf immunoglobulin,production
R9177 T11782 T11783 themeOf HOIP,regulation

events-check-again

Id Subject Object Predicate Lexical cue Speculation
T11784 49-53 Protein denotes HOIP
T11785 70-74 Protein denotes CD40
T11786 141-145 Protein denotes HOIP
T11787 146-155 Regulation denotes dependent
T11788 183-187 Protein denotes CD40
T11789 188-196 Positive_regulation denotes mediated
T11790 197-209 Positive_regulation denotes upregulation
T11791 213-217 Protein denotes CD80
T11792 218-228 Gene_expression denotes expression
T11793 448-452 Protein denotes HOIP
T11794 463-473 Regulation denotes downstream
T11795 477-482 Protein denotes TRAF2
T11796 490-494 Protein denotes CD40
T11797 522-526 Protein denotes HOIP
T11798 537-541 Regulation denotes role
T11799 545-554 Positive_regulation denotes promoting
T11800 559-570 Binding denotes recruitment
T11801 593-597 Protein denotes CD40
T11802 621-625 Protein denotes CD40
T11803 724-728 Protein denotes HOIP
T11804 778-782 Protein denotes CD40
T11805 783-793 Binding denotes engagement
T11806 858-862 Protein denotes HOIP
T11807 889-893 Protein denotes CD40
T11808 937-941 Protein denotes CD40
T11809 1025-1029 Protein denotes HOIP
T11810 1119-1123 Protein denotes HOIP
T11811 1192-1196 Protein denotes HOIP
T11812 1221-1227 Protein denotes HOIL-1
T11813 1399-1407 Binding denotes interact
T11814 1413-1417 Protein denotes IKKγ
T11815 1567-1575 Positive_regulation denotes mediates
T11816 1576-1587 Binding denotes recruitment
T11817 1591-1595 Protein denotes IKKγ
T11818 1640-1644 Protein denotes CD40
T11819 1645-1655 Binding denotes associated
T11820 1656-1660 Protein denotes HOIP
T11821 1674-1678 Regulation denotes role
T11822 1682-1692 Positive_regulation denotes activating
T11823 1693-1697 Protein denotes IKKγ
T11824 1708-1719 Binding denotes recruitment
T11825 1788-1792 Protein denotes IKKγ
T11826 1808-1812 Protein denotes CD40
T11827 1918-1933 Phosphorylation denotes phosphorylation true
T11828 1938-1952 Ubiquitination denotes ubiquitination true
T11829 1983-1989 Negative_regulation denotes reduce
T11830 1983-1989 Negative_regulation denotes reduce
T11831 1993-2000 Positive_regulation denotes enhance
T11832 1993-2000 Positive_regulation denotes enhance
T11833 2001-2005 Protein denotes IKKγ
T11834 2065-2069 Protein denotes HOIP
T11835 2070-2078 Positive_regulation denotes mediates
T11836 2079-2090 Binding denotes recruitment
T11837 2113-2117 Protein denotes CD40
T11838 2131-2135 Protein denotes HOIP
T11839 2139-2148 Binding denotes recruited
T11840 2152-2156 Protein denotes CD40
T11841 2205-2209 Protein denotes HOIP
T11842 2284-2307 Positive_regulation denotes functions as an adaptor
T11843 2316-2327 Binding denotes recruitment
T11844 2350-2354 Protein denotes CD40
T11845 2398-2402 Protein denotes HOIP
T11846 2463-2467 Protein denotes IKKγ
T11847 2487-2494 Binding denotes binding true
T11848 2548-2552 Protein denotes HOIP
T11849 2659-2664 Positive_regulation denotes serve
T11850 2668-2675 Binding denotes recruit
T11851 2676-2680 Protein denotes IKKγ
T11852 2739-2748 Positive_regulation denotes necessary
T11853 2753-2764 Binding denotes recruitment
T11854 2768-2772 Protein denotes HOIP
T11855 2879-2890 Binding denotes recruitment
T11856 2894-2898 Protein denotes HOIP
T11857 2927-2932 Protein denotes TRAF2
T11858 2933-2942 Regulation denotes dependent
T11859 2961-2966 Protein denotes TRAF2
T11860 2971-2975 Protein denotes HOIP
T11861 2985-2993 Binding denotes interact
T11862 3052-3057 Protein denotes TRAF2
T11863 3169-3173 Protein denotes HOIP
T11864 3178-3182 Binding denotes bind
T11865 3192-3201 Binding denotes associate
T11866 3311-3316 Protein denotes TRAF2
T11867 3321-3325 Protein denotes HOIP
T11868 3329-3333 Protein denotes CD40
T11869 3402-3407 Protein denotes TRAF6
T11870 3419-3424 Protein denotes TRAF2
T11871 3525-3529 Protein denotes CD40
T11872 3558-3563 Protein denotes TRAF2
T11873 3567-3572 Protein denotes TRAF6
T11874 3601-3605 Protein denotes CD40
T11875 3631-3636 Protein denotes TRAF6
T11876 3648-3652 Protein denotes HOIP
T11877 3653-3663 Negative_regulation denotes deficiency
T11878 3680-3684 Protein denotes CD40
T11879 3769-3774 Protein denotes TRAF2
T11880 3779-3784 Protein denotes TRAF6
T11881 3805-3809 Protein denotes HOIP
T11882 3856-3860 Protein denotes CD40
T11883 3905-3910 Protein denotes TRAF6
T11884 3949-3959 Negative_regulation denotes disruption
T11885 3967-3979 Entity denotes binding site
T11886 3984-3989 Protein denotes TRAF6
T11887 4019-4023 Protein denotes CD40
T11888 4027-4035 Negative_regulation denotes deletion
T11889 4043-4066 Entity denotes receptor binding domain
T11890 4090-4095 Protein denotes TRAF6
T11891 4134-4139 Protein denotes TRAF6
T11892 4158-4162 Binding denotes bind
T11893 4163-4167 Protein denotes CD40
T11894 4351-4358 Negative_regulation denotes absence
T11895 4362-4366 Protein denotes HOIP
T11896 4450-4454 Protein denotes CD40
T11897 4534-4538 Protein denotes HOIP
T11898 4588-4593 Protein denotes TRAF2
T11899 4597-4602 Protein denotes TRAF6
T11900 4754-4758 Protein denotes HOIP
T11901 4854-4858 Protein denotes HOIP
T11902 4859-4868 Binding denotes interacts
T11903 4893-4900 Protein denotes SHARPIN
T11904 4902-4972 Protein denotes SHANK-associated RH domain interacting protein in postsynaptic density
T11905 5022-5026 Protein denotes HOIP
T11906 5031-5035 Protein denotes HOIL
T11907 5171-5178 Protein denotes SHARPIN
T11908 5453-5457 Binding denotes link
T11909 5466-5473 Protein denotes SHARPIN
T11910 5478-5482 Protein denotes HOIP
T11911 5553-5560 Negative_regulation denotes defects true
T11912 5568-5578 Regulation denotes regulation
T11913 5594-5598 Protein denotes HOIP
R9172 T11786 T11787 causeOf HOIP,dependent
R9176 T11788 T11789 causeOf CD40,mediated
R9178 T11789 T11787 themeOf mediated,dependent
R9179 T11790 T11789 themeOf upregulation,mediated
R9180 T11791 T11792 themeOf CD80,expression
R9181 T11792 T11790 themeOf expression,upregulation
R9182 T11793 T11794 themeOf HOIP,downstream
R9183 T11834 T11835 causeOf HOIP,mediates
R9184 T11795 T11794 causeOf TRAF2,downstream
R9185 T11836 T11835 themeOf recruitment,mediates
R9186 T11837 T11836 themeOf CD40,recruitment
R9187 T11838 T11839 themeOf HOIP,recruited
R9188 T11797 T11798 causeOf HOIP,role
R9189 T11840 T11839 themeOf CD40,recruited
R9190 T11841 T11842 causeOf HOIP,functions as an adaptor
R9191 T11843 T11842 themeOf recruitment,functions as an adaptor
R9192 T11799 T11798 themeOf promoting,role
R9193 T11844 T11843 themeOf CD40,recruitment
R9194 T11846 T11847 themeOf IKKγ,binding
R9195 T11800 T11799 themeOf recruitment,promoting
R9196 T11801 T11800 themeOf CD40,recruitment
R9197 T11850 T11849 themeOf recruit,serve
R9198 T11804 T11805 themeOf CD40,engagement
R9199 T11851 T11850 themeOf IKKγ,recruit
R9200 T11853 T11852 themeOf recruitment,necessary
R9201 T11854 T11853 themeOf HOIP,recruitment
R9202 T11855 T11858 themeOf recruitment,dependent
R9203 T11814 T11813 themeOf IKKγ,interact
R9204 T11856 T11855 themeOf HOIP,recruitment
R9205 T11857 T11858 causeOf TRAF2,dependent
R9206 T11859 T11861 themeOf TRAF2,interact
R9207 T11860 T11861 themeOf HOIP,interact
R9208 T11863 T11864 themeOf HOIP,bind
R9209 T11863 T11865 themeOf HOIP,associate
R9210 T11816 T11815 themeOf recruitment,mediates
R9211 T11817 T11816 themeOf IKKγ,recruitment
R9212 T11818 T11819 themeOf CD40,associated
R9213 T11820 T11819 themeOf HOIP,associated
R9214 T11820 T11821 causeOf HOIP,role
R9215 T11876 T11877 themeOf HOIP,deficiency
R9216 T11820 T11824 themeOf HOIP,recruitment
R9217 T11822 T11821 themeOf activating,role
R9218 T11823 T11822 themeOf IKKγ,activating
R9219 T11825 T11828 themeOf IKKγ,ubiquitination
R9220 T11885 T11884 themeOf binding site,disruption
R9221 T11885 T11887 partOf binding site,CD40
R9222 T11825 T11827 themeOf IKKγ,phosphorylation
R9223 T11827 T11829 causeOf phosphorylation,reduce
R9224 T11889 T11888 themeOf receptor binding domain,deletion
R9225 T11889 T11890 partOf receptor binding domain,TRAF6
R9226 T11891 T11892 themeOf TRAF6,bind
R9227 T11893 T11892 themeOf CD40,bind
R9228 T11895 T11894 themeOf HOIP,absence
R9229 T11827 T11832 causeOf phosphorylation,enhance
R9230 T11828 T11830 causeOf ubiquitination,reduce
R9231 T11828 T11831 causeOf ubiquitination,enhance
R9232 T11901 T11902 themeOf HOIP,interacts
R9233 T11833 T11829 themeOf IKKγ,reduce
R9234 T11903 T11902 themeOf SHARPIN,interacts
R9235 T11904 T11903 equivalentTo SHANK-associated RH domain interacting protein in postsynaptic density,SHARPIN
R9236 T11833 T11830 themeOf IKKγ,reduce
R9237 T11909 T11908 themeOf SHARPIN,link
R9238 T11910 T11908 themeOf HOIP,link
R9239 T11833 T11832 themeOf IKKγ,enhance
R9240 T11833 T11831 themeOf IKKγ,enhance
R9241 T11912 T11911 themeOf regulation,defects
R9242 T11913 T11912 themeOf HOIP,regulation

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T11142 1656-1660 Antecedent denotes HOIP
T11143 1954-1959 Anaphor denotes which
T11144 1873-1907 Antecedent denotes post-transcriptional modifications
T11145 2281-2283 Anaphor denotes it
T11146 2205-2209 Antecedent denotes HOIP
T11147 4874-4883 Anaphor denotes a protein
T11148 4893-4900 Antecedent denotes SHARPIN
T11141 1704-1707 Anaphor denotes its
R8966 T11147 T11148 boundBy a protein,SHARPIN
R8959 T11141 T11142 boundBy its,HOIP
R8962 T11143 T11144 boundBy which,post-transcriptional modifications
R8964 T11145 T11146 boundBy it,HOIP

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T10198 11-14 PRP-DOLLAR- denotes Our
T10199 15-22 NN denotes results
T10200 23-31 VB denotes indicate
T10201 32-36 IN denotes that
T10202 37-40 DT denotes the
T10203 41-48 NN denotes protein
T10204 49-53 NN denotes HOIP
T10205 54-56 VB denotes is
T10206 57-65 JJ denotes critical
T10207 66-69 IN denotes for
T10208 70-82 JJ denotes CD40-induced
T10209 83-90 NN denotes signals
T10210 91-95 WDT denotes that
T10211 96-104 VB denotes regulate
T10212 105-106 NN denotes B
T10213 107-111 NN denotes cell
T10214 112-120 NN denotes function
T10215 122-125 PRP-DOLLAR- denotes Our
T10216 126-130 NN denotes data
T10217 131-135 VB denotes show
T10218 136-140 IN denotes that
T10219 141-155 JJ denotes HOIP-dependent
T10220 156-164 JJ denotes cellular
T10221 165-174 NN denotes responses
T10222 175-182 VB denotes include
T10223 183-196 JJ denotes CD40-mediated
T10224 197-209 NN denotes upregulation
T10225 210-212 IN denotes of
T10226 213-217 NN denotes CD80
T10227 218-228 NN denotes expression
T10228 229-232 CC denotes and
T10229 233-242 NN denotes synthesis
T10230 243-245 IN denotes of
T10231 246-254 NN denotes germline
T10232 255-258 NN denotes RNA
T10233 259-270 NN denotes transcripts
T10234 271-275 IN denotes from
T10235 276-279 DT denotes the
T10236 280-294 NN denotes immunoglobulin
T10237 295-300 JJ denotes heavy
T10238 301-306 NN denotes chain
T10239 307-312 NN denotes locus
T10240 312-313 -COMMA- denotes ,
T10241 314-317 CD denotes two
T10242 318-324 NN denotes events
T10243 325-329 WDT denotes that
T10244 330-333 VB denotes are
T10245 334-343 JJ denotes important
T10246 344-347 IN denotes for
T10247 348-364 JJ denotes T-cell-dependent
T10248 365-382 JJ denotes antibody-mediated
T10249 383-389 JJ denotes immune
T10250 390-399 NN denotes responses
T10251 401-403 IN denotes At
T10252 404-407 DT denotes the
T10253 408-417 JJ denotes molecular
T10254 418-423 NN denotes level
T10255 423-424 -COMMA- denotes ,
T10256 425-428 PRP-DOLLAR- denotes our
T10257 429-433 NN denotes data
T10258 434-442 VB denotes indicate
T10259 443-447 IN denotes that
T10260 448-452 NN denotes HOIP
T10261 453-462 NN denotes functions
T10262 463-473 JJ denotes downstream
T10263 474-476 IN denotes of
T10264 477-482 NN denotes TRAF2
T10265 483-485 IN denotes in
T10267 490-494 NN denotes CD40
T10268 495-504 NN denotes signaling
T10269 505-512 NN denotes pathway
T10270 513-516 CC denotes and
T10271 517-521 IN denotes that
T10272 522-526 NN denotes HOIP
T10273 527-530 VB denotes has
T10274 531-532 DT denotes a
T10275 533-536 JJ denotes key
T10276 537-541 NN denotes role
T10277 542-544 IN denotes in
T10278 545-554 VB denotes promoting
T10279 555-558 DT denotes the
T10280 559-570 NN denotes recruitment
T10281 571-573 IN denotes of
T10282 574-577 DT denotes the
T10283 578-581 NN denotes IKK
T10284 582-589 NN denotes complex
T10285 590-592 TO denotes to
T10286 593-597 NN denotes CD40
T10287 599-609 JJ denotes Consistent
T10288 610-614 IN denotes with
T10289 615-619 DT denotes this
T10290 619-620 -COMMA- denotes ,
T10291 621-633 JJ denotes CD40-induced
T10292 634-644 NN denotes activation
T10293 645-647 IN denotes of
T10294 648-653 NN denotes NF-κB
T10295 654-656 VB denotes is
T10296 657-666 JJ denotes dependent
T10297 667-669 IN denotes on
T10298 670-673 DT denotes the
T10299 674-682 NN denotes presence
T10300 683-685 IN denotes of
T10301 686-690 NN denotes HOIP
T10302 692-694 IN denotes In
T10303 695-703 NN denotes addition
T10304 703-704 -COMMA- denotes ,
T10305 705-708 PRP-DOLLAR- denotes our
T10306 709-713 NN denotes data
T10307 714-718 VB denotes show
T10308 719-723 IN denotes that
T10309 724-728 NN denotes HOIP
T10310 729-740 VB denotes facilitates
T10311 741-744 DT denotes the
T10312 745-755 NN denotes activation
T10313 756-758 IN denotes of
T10314 759-762 NN denotes JNK
T10315 763-765 IN denotes in
T10316 766-774 NN denotes response
T10317 775-777 TO denotes to
T10318 778-782 NN denotes CD40
T10319 783-793 NN denotes engagement
T10320 795-803 RB denotes Together
T10321 803-804 -COMMA- denotes ,
T10322 805-808 PRP-DOLLAR- denotes our
T10323 809-817 NN denotes findings
T10324 818-825 VB denotes provide
T10325 826-833 NN denotes support
T10326 834-837 IN denotes for
T10327 838-841 DT denotes the
T10328 842-852 NN denotes conclusion
T10329 853-857 IN denotes that
T10330 858-862 NN denotes HOIP
T10331 863-865 VB denotes is
T10332 866-867 DT denotes a
T10333 868-871 JJ denotes key
T10334 872-881 NN denotes component
T10335 882-884 IN denotes of
T10336 885-888 DT denotes the
T10337 889-893 NN denotes CD40
T10338 894-903 NN denotes signaling
T10339 904-911 NN denotes pathway
T10340 913-918 VB denotes Given
T10341 919-922 DT denotes the
T10342 923-933 NN denotes importance
T10343 934-936 IN denotes of
T10344 937-941 NN denotes CD40
T10345 942-951 NN denotes signaling
T10346 952-954 IN denotes in
T10347 955-959 CC denotes both
T10348 960-968 JJ denotes cellular
T10349 969-972 CC denotes and
T10350 973-980 JJ denotes humoral
T10351 981-987 JJ denotes immune
T10352 988-997 NN denotes responses
T10353 997-998 -COMMA- denotes ,
T10354 999-1002 PRP-DOLLAR- denotes our
T10355 1003-1010 NN denotes results
T10356 1011-1019 VB denotes indicate
T10357 1020-1024 IN denotes that
T10358 1025-1029 NN denotes HOIP
T10359 1030-1033 VB denotes has
T10360 1034-1035 DT denotes a
T10361 1036-1044 JJ denotes critical
T10362 1045-1049 NN denotes role
T10363 1050-1052 IN denotes in
T10364 1053-1056 DT denotes the
T10365 1057-1067 NN denotes regulation
T10366 1068-1070 IN denotes of
T10367 1071-1074 DT denotes the
T10368 1075-1081 JJ denotes immune
T10369 1082-1088 NN denotes system
T10370 1090-1093 DT denotes The
T10371 1094-1104 JJ denotes functional
T10372 1105-1115 NN denotes properties
T10373 1116-1118 IN denotes of
T10374 1119-1123 NN denotes HOIP
T10375 1124-1128 VB denotes have
T10376 1129-1133 RB denotes only
T10377 1134-1138 VB denotes been
T10378 1139-1148 RB denotes partially
T10379 1149-1162 VB denotes characterized
T10380 1164-1171 JJ denotes Initial
T10381 1172-1179 NN denotes studies
T10382 1180-1186 VB denotes showed
T10383 1187-1191 IN denotes that
T10384 1192-1196 NN denotes HOIP
T10385 1197-1200 CC denotes and
T10386 1201-1204 DT denotes the
T10387 1205-1212 VB denotes related
T10388 1213-1220 NN denotes protein
T10389 1221-1227 NN denotes HOIL-1
T10390 1228-1231 VB denotes are
T10391 1232-1242 NN denotes components
T10392 1243-1245 IN denotes of
T10393 1246-1247 DT denotes a
T10394 1248-1253 JJ denotes large
T10395 1254-1255 -LRB- denotes (
T10396 1255-1259 CD denotes ∼600
T10397 1260-1263 NN denotes kDa
T10398 1263-1264 -RRB- denotes )
T10399 1265-1272 NN denotes protein
T10400 1273-1280 NN denotes complex
T10401 1281-1288 JJ denotes capable
T10402 1289-1291 IN denotes of
T10403 1292-1304 VB denotes synthesizing
T10404 1305-1311 JJ denotes linear
T10405 1312-1325 NN denotes polyubiquitin
T10406 1326-1332 NN denotes chains
T10407 1333-1334 -LRB- denotes [
T10408 1334-1335 CD denotes 5
T10409 1335-1336 -RRB- denotes ]
T10410 1338-1348 JJ denotes Subsequent
T10411 1349-1356 NN denotes studies
T10412 1357-1363 VB denotes showed
T10413 1364-1368 IN denotes that
T10414 1369-1370 DT denotes a
T10415 1371-1386 JJ denotes HOIP-containing
T10416 1387-1394 NN denotes complex
T10417 1395-1398 MD denotes can
T10418 1399-1407 VB denotes interact
T10419 1408-1412 IN denotes with
T10420 1413-1417 NN denotes IKKγ
T10421 1418-1421 CC denotes and
T10422 1422-1432 VB denotes facilitate
T10423 1433-1443 NN denotes activation
T10424 1444-1446 IN denotes of
T10425 1447-1452 NN denotes NF-κB
T10426 1453-1456 IN denotes via
T10427 1457-1460 DT denotes the
T10428 1461-1470 JJ denotes canonical
T10429 1471-1478 NN denotes pathway
T10430 1479-1480 -LRB- denotes [
T10431 1480-1482 CD denotes 16
T10432 1482-1483 -RRB- denotes ]
T10433 1485-1490 DT denotes These
T10434 1491-1495 NN denotes data
T10435 1495-1496 -COMMA- denotes ,
T10436 1497-1507 VB denotes considered
T10437 1508-1516 RB denotes together
T10438 1517-1521 IN denotes with
T10439 1522-1526 NN denotes ours
T10440 1526-1527 -COMMA- denotes ,
T10441 1528-1535 VB denotes suggest
T10442 1536-1540 IN denotes that
T10443 1541-1542 DT denotes a
T10444 1543-1558 JJ denotes HOIP-containing
T10445 1559-1566 NN denotes complex
T10446 1567-1575 VB denotes mediates
T10447 1576-1587 NN denotes recruitment
T10448 1588-1590 IN denotes of
T10449 1591-1595 NN denotes IKKγ
T10450 1596-1598 TO denotes to
T10451 1599-1602 DT denotes the
T10452 1603-1607 NN denotes CD40
T10453 1608-1617 NN denotes signaling
T10454 1618-1625 NN denotes complex
T10455 1627-1629 IN denotes In
T10456 1630-1638 NN denotes addition
T10457 1638-1639 -COMMA- denotes ,
T10458 1640-1655 JJ denotes CD40-associated
T10459 1656-1660 NN denotes HOIP
T10460 1661-1666 MD denotes could
T10461 1667-1671 VB denotes play
T10462 1672-1673 DT denotes a
T10463 1674-1678 NN denotes role
T10464 1679-1681 IN denotes in
T10465 1682-1692 VB denotes activating
T10466 1693-1697 NN denotes IKKγ
T10467 1698-1703 IN denotes after
T10468 1704-1707 PRP-DOLLAR- denotes its
T10469 1708-1719 NN denotes recruitment
T10470 1720-1722 TO denotes to
T10471 1723-1726 DT denotes the
T10472 1727-1736 NN denotes signaling
T10473 1737-1744 NN denotes complex
T10474 1745-1746 -LRB- denotes [
T10475 1746-1748 CD denotes 16
T10476 1748-1749 -RRB- denotes ]
T10477 1751-1754 DT denotes The
T10478 1755-1761 JJ denotes higher
T10479 1762-1771 JJ denotes molecular
T10480 1772-1778 NN denotes weight
T10481 1779-1784 NN denotes forms
T10482 1785-1787 IN denotes of
T10483 1788-1792 NN denotes IKKγ
T10484 1793-1795 PRP denotes we
T10485 1796-1804 VB denotes observed
T10486 1805-1807 IN denotes in
T10487 1808-1812 NN denotes CD40
T10488 1813-1831 NN denotes immunoprecipitates
T10489 1832-1837 MD denotes would
T10490 1838-1840 VB denotes be
T10491 1841-1851 JJ denotes consistent
T10492 1852-1856 IN denotes with
T10493 1857-1860 DT denotes the
T10494 1861-1869 NN denotes presence
T10495 1870-1872 IN denotes of
T10496 1873-1893 JJ denotes post-transcriptional
T10497 1894-1907 NN denotes modifications
T10498 1908-1917 VB denotes including
T10499 1918-1933 NN denotes phosphorylation
T10500 1934-1937 CC denotes and
T10501 1938-1952 NN denotes ubiquitination
T10502 1952-1953 -COMMA- denotes ,
T10503 1954-1959 WDT denotes which
T10504 1960-1964 VB denotes have
T10505 1965-1969 VB denotes been
T10506 1970-1979 VB denotes suggested
T10507 1980-1982 TO denotes to
T10508 1983-1989 VB denotes reduce
T10509 1990-1992 CC denotes or
T10510 1993-2000 VB denotes enhance
T10511 2001-2005 NN denotes IKKγ
T10512 2006-2014 NN denotes activity
T10513 2014-2015 -COMMA- denotes ,
T10514 2016-2028 RB denotes respectively
T10515 2029-2030 -LRB- denotes [
T10516 2030-2032 CD denotes 16
T10517 2032-2033 -RRB- denotes ]
T10518 2033-2034 -COMMA- denotes ,
T10519 2035-2036 -LRB- denotes [
T10520 2036-2038 CD denotes 17
T10521 2038-2039 -RRB- denotes ]
T10522 2041-2044 DT denotes The
T10523 2045-2055 NN denotes mechanisms
T10524 2056-2058 IN denotes by
T10525 2059-2064 WDT denotes which
T10526 2065-2069 NN denotes HOIP
T10527 2070-2078 VB denotes mediates
T10528 2079-2090 NN denotes recruitment
T10529 2091-2093 IN denotes of
T10530 2094-2097 DT denotes the
T10531 2098-2101 NN denotes IKK
T10532 2102-2109 NN denotes complex
T10533 2110-2112 TO denotes to
T10534 2113-2117 NN denotes CD40
T10535 2118-2121 CC denotes and
T10536 2122-2124 IN denotes by
T10537 2125-2130 WDT denotes which
T10538 2131-2135 NN denotes HOIP
T10539 2136-2138 VB denotes is
T10540 2139-2148 VB denotes recruited
T10541 2149-2151 TO denotes to
T10542 2152-2156 NN denotes CD40
T10543 2157-2163 VB denotes remain
T10544 2164-2171 JJ denotes unclear
T10545 2173-2174 DT denotes A
T10546 2175-2183 JJ denotes previous
T10547 2184-2189 NN denotes study
T10548 2190-2199 VB denotes indicates
T10549 2200-2204 IN denotes that
T10550 2205-2209 NN denotes HOIP
T10551 2210-2213 MD denotes may
T10552 2214-2221 VB denotes mediate
T10553 2222-2228 JJ denotes direct
T10554 2229-2237 NN denotes contacts
T10555 2238-2242 IN denotes with
T10556 2243-2246 DT denotes the
T10557 2247-2250 NN denotes IKK
T10558 2251-2258 NN denotes complex
T10559 2259-2260 -LRB- denotes [
T10560 2260-2262 CD denotes 16
T10561 2262-2263 -RRB- denotes ]
T10562 2263-2264 -COMMA- denotes ,
T10563 2265-2275 VB denotes suggesting
T10564 2276-2280 IN denotes that
T10565 2281-2283 PRP denotes it
T10566 2284-2293 VB denotes functions
T10567 2294-2296 IN denotes as
T10568 2297-2299 DT denotes an
T10569 2300-2307 NN denotes adaptor
T10570 2308-2311 IN denotes for
T10571 2312-2315 DT denotes the
T10572 2316-2327 NN denotes recruitment
T10573 2328-2330 IN denotes of
T10574 2331-2334 DT denotes the
T10575 2335-2338 NN denotes IKK
T10576 2339-2346 NN denotes complex
T10577 2347-2349 TO denotes to
T10578 2350-2354 NN denotes CD40
T10579 2356-2363 RB denotes However
T10580 2363-2364 -COMMA- denotes ,
T10581 2365-2368 DT denotes the
T10582 2369-2378 NN denotes ubiquitin
T10583 2379-2385 NN denotes ligase
T10584 2386-2394 NN denotes activity
T10585 2395-2397 IN denotes of
T10586 2398-2402 NN denotes HOIP
T10587 2403-2411 VB denotes suggests
T10588 2412-2416 IN denotes that
T10589 2417-2419 PRP denotes it
T10590 2420-2422 VB denotes is
T10591 2423-2427 JJ denotes more
T10592 2428-2432 IN denotes than
T10593 2433-2434 DT denotes a
T10594 2435-2441 JJ denotes simple
T10595 2442-2449 NN denotes adapter
T10596 2450-2458 NN denotes molecule
T10597 2460-2462 IN denotes As
T10598 2463-2467 NN denotes IKKγ
T10599 2468-2475 VB denotes appears
T10600 2476-2483 JJ denotes capable
T10601 2484-2486 IN denotes of
T10602 2487-2494 VB denotes binding
T10603 2495-2501 JJ denotes linear
T10604 2502-2515 NN denotes polyubiquitin
T10605 2516-2517 -LRB- denotes [
T10606 2517-2519 CD denotes 18
T10607 2519-2520 -RRB- denotes ]
T10608 2520-2521 -COMMA- denotes ,
T10609 2522-2523 -LRB- denotes [
T10610 2523-2525 CD denotes 19
T10611 2525-2526 -RRB- denotes ]
T10612 2526-2527 -COMMA- denotes ,
T10613 2528-2530 PRP denotes it
T10614 2531-2533 VB denotes is
T10615 2534-2542 JJ denotes possible
T10616 2543-2547 IN denotes that
T10617 2548-2552 NN denotes HOIP
T10618 2553-2560 VB denotes directs
T10619 2561-2570 NN denotes formation
T10620 2571-2573 IN denotes of
T10621 2574-2580 JJ denotes linear
T10622 2581-2594 NN denotes polyubiquitin
T10623 2595-2601 NN denotes chains
T10624 2602-2604 IN denotes on
T10625 2605-2606 DT denotes a
T10626 2607-2622 JJ denotes CD40-associated
T10627 2623-2629 NN denotes factor
T10628 2629-2630 -COMMA- denotes ,
T10629 2631-2634 CC denotes and
T10630 2635-2637 PRP denotes it
T10631 2638-2640 VB denotes is
T10632 2641-2646 DT denotes these
T10633 2647-2653 NN denotes chains
T10634 2654-2658 WDT denotes that
T10635 2659-2664 VB denotes serve
T10636 2665-2667 TO denotes to
T10637 2668-2675 VB denotes recruit
T10638 2676-2680 NN denotes IKKγ
T10639 2681-2683 TO denotes to
T10640 2684-2687 DT denotes the
T10641 2688-2692 NN denotes CD40
T10642 2693-2702 NN denotes signaling
T10643 2703-2710 NN denotes complex
T10644 2712-2715 DT denotes The
T10645 2716-2725 JJ denotes molecular
T10646 2726-2738 NN denotes interactions
T10647 2739-2748 JJ denotes necessary
T10648 2749-2752 IN denotes for
T10649 2753-2764 NN denotes recruitment
T10650 2765-2767 IN denotes of
T10651 2768-2772 NN denotes HOIP
T10652 2773-2779 PRP denotes itself
T10653 2780-2782 TO denotes to
T10654 2783-2786 DT denotes the
T10655 2787-2791 NN denotes CD40
T10656 2792-2801 NN denotes signaling
T10657 2802-2809 NN denotes complex
T10658 2810-2814 RB denotes also
T10659 2815-2821 VB denotes remain
T10660 2822-2824 TO denotes to
T10661 2825-2827 VB denotes be
T10662 2828-2833 RB denotes fully
T10663 2834-2847 VB denotes characterized
T10664 2849-2851 PRP denotes We
T10665 2852-2862 RB denotes previously
T10666 2863-2869 VB denotes showed
T10667 2870-2874 IN denotes that
T10668 2875-2878 DT denotes the
T10669 2879-2890 NN denotes recruitment
T10670 2891-2893 IN denotes of
T10671 2894-2898 NN denotes HOIP
T10672 2899-2901 TO denotes to
T10673 2902-2905 DT denotes the
T10674 2906-2915 NN denotes signaling
T10675 2916-2923 NN denotes complex
T10676 2924-2926 VB denotes is
T10677 2927-2942 JJ denotes TRAF2-dependent
T10678 2943-2944 -LRB- denotes [
T10679 2944-2945 CD denotes 8
T10680 2945-2946 -RRB- denotes ]
T10681 2948-2959 RB denotes Potentially
T10682 2959-2960 -COMMA- denotes ,
T10683 2961-2966 NN denotes TRAF2
T10684 2967-2970 CC denotes and
T10685 2971-2975 NN denotes HOIP
T10686 2976-2984 RB denotes directly
T10687 2985-2993 VB denotes interact
T10688 2993-2994 -COMMA- denotes ,
T10689 2995-2998 CC denotes but
T10690 2999-3001 PRP denotes it
T10691 3002-3004 VB denotes is
T10692 3005-3013 JJ denotes possible
T10693 3014-3018 IN denotes that
T10694 3019-3022 DT denotes the
T10695 3023-3032 NN denotes ubiquitin
T10696 3033-3039 NN denotes ligase
T10697 3040-3048 NN denotes activity
T10698 3049-3051 IN denotes of
T10699 3052-3057 NN denotes TRAF2
T10700 3058-3059 -LRB- denotes [
T10701 3059-3061 CD denotes 20
T10702 3061-3062 -RRB- denotes ]
T10703 3063-3064 -LRB- denotes (
T10704 3064-3066 CC denotes or
T10705 3067-3083 JJ denotes TRAF2-associated
T10706 3084-3092 NN denotes proteins
T10707 3092-3093 -COMMA- denotes ,
T10708 3094-3098 JJ denotes such
T10709 3099-3101 IN denotes as
T10710 3102-3105 DT denotes the
T10711 3106-3111 NN denotes cIAPs
T10712 3112-3113 -LRB- denotes [
T10713 3113-3115 CD denotes 21
T10714 3115-3116 -RRB- denotes ]
T10715 3116-3117 -RRB- denotes )
T10716 3118-3127 VB denotes generates
T10717 3128-3138 JJ denotes K63-linked
T10718 3139-3152 NN denotes polyubiquitin
T10719 3153-3159 NN denotes chains
T10720 3160-3162 TO denotes to
T10721 3163-3168 WDT denotes which
T10722 3169-3173 NN denotes HOIP
T10723 3174-3177 MD denotes can
T10724 3178-3182 VB denotes bind
T10725 3183-3186 CC denotes and
T10726 3187-3191 RB denotes thus
T10727 3192-3201 VB denotes associate
T10728 3202-3206 IN denotes with
T10729 3207-3210 DT denotes the
T10730 3211-3215 NN denotes CD40
T10731 3216-3225 NN denotes signaling
T10732 3226-3233 NN denotes complex
T10733 3234-3235 -LRB- denotes [
T10734 3235-3237 CD denotes 22
T10735 3237-3238 -RRB- denotes ]
T10736 3240-3245 IN denotes While
T10737 3246-3249 PRP-DOLLAR- denotes our
T10738 3250-3258 JJ denotes previous
T10739 3259-3263 NN denotes work
T10740 3264-3273 VB denotes indicated
T10741 3274-3275 DT denotes a
T10742 3276-3287 RB denotes potentially
T10743 3288-3297 JJ denotes important
T10744 3298-3302 NN denotes link
T10745 3303-3310 IN denotes between
T10746 3311-3316 NN denotes TRAF2
T10747 3317-3320 CC denotes and
T10748 3321-3325 NN denotes HOIP
T10819 3726-3727 -COMMA- denotes ,
T10820 3728-3738 VB denotes indicating
T10749 3326-3328 IN denotes in
T10750 3329-3333 NN denotes CD40
T10751 3334-3343 NN denotes signaling
T10752 3343-3344 -COMMA- denotes ,
T10753 3345-3348 DT denotes the
T10754 3349-3356 NN denotes signals
T10755 3357-3360 CC denotes and
T10756 3361-3370 NN denotes functions
T10757 3371-3377 VB denotes tested
T10758 3378-3382 RB denotes here
T10759 3383-3386 VB denotes are
T10760 3387-3396 JJ denotes dependent
T10761 3397-3401 IN denotes upon
T10762 3402-3407 NN denotes TRAF6
T10763 3408-3410 RB denotes as
T10764 3411-3415 RB denotes well
T10765 3416-3418 IN denotes as
T10766 3419-3424 NN denotes TRAF2
T10767 3426-3428 IN denotes In
T10768 3429-3437 JJ denotes previous
T10769 3438-3449 NN denotes experiments
T10770 3450-3454 IN denotes with
T10771 3455-3469 JJ denotes TRAF-deficient
T10772 3470-3476 NN denotes A20.2J
T10773 3477-3482 NN denotes cells
T10774 3482-3483 -COMMA- denotes ,
T10775 3484-3486 PRP denotes we
T10776 3487-3492 VB denotes found
T10777 3493-3497 IN denotes that
T10778 3498-3501 DT denotes the
T10779 3502-3512 NN denotes activation
T10780 3513-3515 IN denotes of
T10781 3516-3521 NN denotes NF-κB
T10782 3522-3524 IN denotes by
T10783 3525-3529 NN denotes CD40
T10784 3530-3535 MD denotes could
T10785 3536-3538 VB denotes be
T10786 3539-3547 VB denotes mediated
T10787 3548-3550 IN denotes by
T10788 3551-3557 CC denotes either
T10789 3558-3563 NN denotes TRAF2
T10790 3564-3566 CC denotes or
T10791 3567-3572 NN denotes TRAF6
T10792 3572-3573 -COMMA- denotes ,
T10793 3574-3579 IN denotes while
T10794 3580-3590 NN denotes activation
T10795 3591-3593 IN denotes of
T10796 3594-3597 NN denotes JNK
T10797 3598-3600 IN denotes by
T10798 3601-3605 NN denotes CD40
T10799 3606-3609 VB denotes was
T10800 3610-3617 RB denotes largely
T10801 3618-3627 JJ denotes dependent
T10802 3628-3630 IN denotes on
T10803 3631-3636 NN denotes TRAF6
T10804 3637-3642 RB denotes alone
T10805 3643-3644 -LRB- denotes [
T10806 3644-3645 CD denotes 8
T10807 3645-3646 -RRB- denotes ]
T10808 3648-3652 NN denotes HOIP
T10809 3653-3663 NN denotes deficiency
T10810 3664-3675 VB denotes compromises
T10811 3676-3679 DT denotes the
T10812 3680-3693 JJ denotes CD40-mediated
T10813 3694-3704 NN denotes activation
T10814 3705-3707 IN denotes of
T10815 3708-3712 CC denotes both
T10816 3713-3718 NN denotes NF-κB
T10817 3719-3722 CC denotes and
T10818 3723-3726 NN denotes JNK
T10821 3739-3743 IN denotes that
T10822 3744-3751 NN denotes signals
T10823 3752-3760 VB denotes mediated
T10824 3761-3763 IN denotes by
T10825 3764-3768 CC denotes both
T10826 3769-3774 NN denotes TRAF2
T10827 3775-3778 CC denotes and
T10828 3779-3784 NN denotes TRAF6
T10829 3785-3791 RB denotes likely
T10830 3792-3796 VB denotes pass
T10831 3797-3804 IN denotes through
T10832 3805-3809 NN denotes HOIP
T10833 3811-3814 PRP-DOLLAR- denotes Our
T10834 3815-3823 JJ denotes previous
T10835 3824-3828 NN denotes work
T10836 3829-3833 RB denotes also
T10837 3834-3846 VB denotes demonstrated
T10838 3847-3851 IN denotes that
T10839 3852-3855 DT denotes the
T10840 3856-3869 JJ denotes CD40-mediated
T10841 3870-3880 NN denotes activation
T10842 3881-3883 IN denotes of
T10843 3884-3889 NN denotes NF-κB
T10844 3890-3893 CC denotes and
T10845 3894-3897 NN denotes JNK
T10846 3897-3898 -COMMA- denotes ,
T10848 3905-3920 JJ denotes TRAF6-dependent
T10849 3920-3921 -COMMA- denotes ,
T10850 3922-3925 VB denotes was
T10851 3926-3929 RB denotes not
T10852 3930-3941 VB denotes compromised
T10853 3942-3944 IN denotes by
T10854 3945-3948 DT denotes the
T10855 3949-3959 NN denotes disruption
T10856 3960-3962 IN denotes of
T10857 3963-3966 DT denotes the
T10858 3967-3974 VB denotes binding
T10859 3975-3979 NN denotes site
T10860 3980-3983 IN denotes for
T10861 3984-3989 NN denotes TRAF6
T10862 3990-3992 IN denotes in
T10863 3993-3996 DT denotes the
T10864 3997-4008 JJ denotes cytoplasmic
T10865 4009-4015 NN denotes domain
T10866 4016-4018 IN denotes of
T10867 4019-4023 NN denotes CD40
T10868 4024-4026 CC denotes or
T10869 4027-4035 NN denotes deletion
T10870 4036-4038 IN denotes of
T10871 4039-4042 DT denotes the
T10872 4043-4051 NN denotes receptor
T10873 4052-4059 NN denotes binding
T10874 4060-4066 NN denotes domain
T10875 4067-4068 -LRB- denotes (
T10876 4068-4071 DT denotes the
T10877 4072-4078 NN denotes TRAF-C
T10878 4079-4085 NN denotes domain
T10879 4085-4086 -RRB- denotes )
T10880 4087-4089 IN denotes in
T10881 4090-4095 NN denotes TRAF6
T10882 4096-4097 -LRB- denotes [
T10883 4097-4098 CD denotes 8
T10884 4098-4099 -RRB- denotes ]
T10885 4101-4106 DT denotes These
T10886 4107-4119 NN denotes observations
T10887 4120-4128 VB denotes indicate
T10888 4129-4133 IN denotes that
T10889 4134-4139 NN denotes TRAF6
T10890 4140-4144 VB denotes need
T10891 4145-4148 RB denotes not
T10892 4149-4157 RB denotes directly
T10893 4158-4162 VB denotes bind
T10894 4163-4167 NN denotes CD40
T10895 4168-4170 IN denotes in
T10896 4171-4176 NN denotes order
T10897 4177-4179 TO denotes to
T10898 4180-4187 VB denotes mediate
T10899 4188-4195 JJ denotes certain
T10900 4196-4203 NN denotes signals
T10901 4203-4204 -COMMA- denotes ,
T10902 4205-4215 VB denotes suggesting
T10903 4216-4219 DT denotes the
T10904 4220-4228 NN denotes assembly
T10905 4229-4231 IN denotes of
T10906 4232-4233 DT denotes a
T10907 4234-4243 NN denotes signaling
T10908 4244-4251 NN denotes complex
T10909 4252-4255 RB denotes not
T10910 4256-4264 RB denotes directly
T10911 4265-4275 VB denotes associated
T10912 4276-4280 IN denotes with
T10913 4281-4284 DT denotes the
T10914 4285-4293 NN denotes receptor
T10915 4295-4297 IN denotes If
T10916 4298-4302 PDT denotes such
T10917 4303-4304 DT denotes a
T10918 4305-4312 NN denotes complex
T10919 4313-4319 VB denotes exists
T10920 4319-4320 -COMMA- denotes ,
T10921 4321-4324 PRP-DOLLAR- denotes our
T10922 4325-4332 NN denotes results
T10923 4333-4341 VB denotes indicate
T10924 4342-4346 IN denotes that
T10925 4347-4350 DT denotes the
T10926 4351-4358 NN denotes absence
T10927 4359-4361 IN denotes of
T10928 4362-4366 NN denotes HOIP
T10929 4367-4378 VB denotes compromises
T10930 4379-4382 PRP-DOLLAR- denotes its
T10931 4383-4391 NN denotes function
T10932 4392-4394 RB denotes as
T10933 4395-4399 RB denotes well
T10934 4401-4409 IN denotes Although
T10935 4410-4413 DT denotes the
T10936 4414-4425 NN denotes experiments
T10937 4426-4435 VB denotes presented
T10938 4436-4440 RB denotes here
T10939 4441-4446 VB denotes focus
T10940 4447-4449 IN denotes on
T10941 4450-4454 NN denotes CD40
T10942 4454-4455 -COMMA- denotes ,
T10943 4456-4459 PRP-DOLLAR- denotes our
T10944 4460-4467 NN denotes results
T10945 4468-4471 CC denotes and
T10946 4472-4477 DT denotes those
T10947 4478-4480 IN denotes of
T10948 4481-4486 JJ denotes other
T10949 4487-4493 NN denotes groups
T10950 4494-4495 -LRB- denotes [
T10951 4495-4497 CD denotes 16
T10952 4497-4498 -RRB- denotes ]
T10953 4498-4499 -COMMA- denotes ,
T10954 4500-4501 -LRB- denotes [
T10955 4501-4503 CD denotes 22
T10956 4503-4504 -RRB- denotes ]
T10957 4505-4512 VB denotes support
T10958 4513-4516 DT denotes the
T10959 4517-4528 NN denotes possibility
T10960 4529-4533 IN denotes that
T10961 4534-4538 NN denotes HOIP
T10962 4539-4541 VB denotes is
T10963 4542-4551 JJ denotes important
T10964 4552-4554 IN denotes in
T10965 4555-4559 JJ denotes many
T10966 4560-4569 NN denotes signaling
T10967 4570-4578 NN denotes pathways
T10968 4579-4581 IN denotes in
T10969 4582-4587 WDT denotes which
T10970 4588-4593 NN denotes TRAF2
T10971 4594-4596 CC denotes or
T10972 4597-4602 NN denotes TRAF6
T10973 4603-4606 VB denotes are
T10974 4607-4615 VB denotes involved
T10975 4615-4616 -COMMA- denotes ,
T10976 4617-4626 VB denotes including
T10977 4627-4632 DT denotes those
T10978 4633-4643 VB denotes associated
T10979 4644-4648 IN denotes with
T10980 4649-4656 JJ denotes various
T10981 4657-4664 NN denotes members
T10982 4665-4667 IN denotes of
T10983 4668-4671 DT denotes the
T10984 4672-4675 NN denotes TNF
T10985 4676-4684 NN denotes receptor
T10986 4685-4696 NN denotes superfamily
T10987 4697-4700 CC denotes and
T10988 4701-4704 DT denotes the
T10989 4705-4714 JJ denotes Toll-like
T10990 4715-4724 NN denotes receptors
T10991 4726-4729 DT denotes The
T10992 4730-4739 JJ denotes potential
T10993 4740-4750 NN denotes importance
T10994 4751-4753 IN denotes of
T10995 4754-4758 NN denotes HOIP
T10996 4759-4761 IN denotes in
T10997 4762-4768 JJ denotes immune
T10998 4769-4777 NN denotes function
T10999 4778-4781 CC denotes and
T11000 4782-4786 NN denotes TNFR
T11001 4787-4793 NN denotes family
T11002 4794-4803 NN denotes signaling
T11003 4804-4806 VB denotes is
T11004 4807-4814 RB denotes further
T11005 4815-4824 VB denotes supported
T11006 4825-4827 IN denotes by
T11007 4828-4831 DT denotes the
T11008 4832-4838 JJ denotes recent
T11009 4839-4848 NN denotes discovery
T11010 4849-4853 IN denotes that
T11011 4854-4858 NN denotes HOIP
T11012 4859-4868 VB denotes interacts
T11013 4869-4873 IN denotes with
T11014 4874-4875 DT denotes a
T11015 4876-4883 NN denotes protein
T11016 4884-4889 VB denotes known
T11017 4890-4892 IN denotes as
T11018 4893-4900 NN denotes SHARPIN
T11019 4901-4902 -LRB- denotes (
T11020 4902-4918 JJ denotes SHANK-associated
T11021 4919-4921 NN denotes RH
T11022 4922-4928 NN denotes domain
T11023 4929-4940 VB denotes interacting
T11024 4941-4948 NN denotes protein
T11025 4949-4951 IN denotes in
T11026 4952-4964 JJ denotes postsynaptic
T11027 4965-4972 NN denotes density
T11028 4972-4973 -RRB- denotes )
T11029 4973-4974 -COMMA- denotes ,
T11030 4975-4980 WDT denotes which
T11031 4981-4988 VB denotes appears
T11032 4989-4996 JJ denotes capable
T11033 4997-4999 IN denotes of
T11034 5000-5007 VB denotes working
T11035 5008-5016 RB denotes together
T11036 5017-5021 IN denotes with
T11037 5022-5026 NN denotes HOIP
T11038 5027-5030 CC denotes and
T11039 5031-5035 NN denotes HOIL
T11040 5036-5038 TO denotes to
T11041 5039-5046 VB denotes mediate
T11042 5047-5050 DT denotes the
T11043 5051-5059 NN denotes assembly
T11044 5060-5062 IN denotes of
T11045 5063-5069 JJ denotes linear
T11046 5070-5083 NN denotes polyubiquitin
T11047 5084-5085 -LRB- denotes [
T11048 5085-5087 CD denotes 14
T11049 5087-5088 -RRB- denotes ]
T11050 5088-5089 -COMMA- denotes ,
T11051 5090-5091 -LRB- denotes [
T11052 5091-5093 CD denotes 23
T11053 5093-5094 -RRB- denotes ]
T11054 5094-5095 -COMMA- denotes ,
T11055 5096-5097 -LRB- denotes [
T11056 5097-5099 CD denotes 24
T11057 5099-5100 -RRB- denotes ]
T11058 5102-5115 RB denotes Interestingly
T11059 5115-5116 -COMMA- denotes ,
T11060 5117-5121 NN denotes mice
T11061 5122-5126 IN denotes with
T11062 5127-5128 DT denotes a
T11063 5129-5140 JJ denotes spontaneous
T11064 5141-5149 NN denotes mutation
T11065 5150-5152 IN denotes in
T11066 5153-5156 DT denotes the
T11067 5157-5161 NN denotes gene
T11068 5162-5170 VB denotes encoding
T11069 5171-5178 NN denotes SHARPIN
T11070 5179-5180 -LRB- denotes (
T11071 5180-5187 JJ denotes chronic
T11072 5188-5201 JJ denotes proliferative
T11073 5202-5212 NN denotes dermatitis
T11074 5213-5214 -LRB- denotes (
T11075 5214-5218 NN denotes cpdm
T11076 5218-5219 -RRB- denotes )
T11077 5220-5224 NN denotes mice
T11078 5224-5225 -RRB- denotes )
T11079 5226-5233 VB denotes exhibit
T11080 5234-5241 JJ denotes chronic
T11081 5242-5254 NN denotes inflammation
T11082 5255-5257 IN denotes of
T11083 5258-5261 DT denotes the
T11084 5262-5266 NN denotes skin
T11085 5267-5270 CC denotes and
T11086 5271-5279 JJ denotes internal
T11087 5280-5286 NN denotes organs
T11088 5286-5287 -COMMA- denotes ,
T11089 5288-5297 JJ denotes defective
T11090 5298-5309 NN denotes development
T11091 5310-5312 IN denotes of
T11092 5313-5322 JJ denotes secondary
T11093 5323-5331 JJ denotes lymphoid
T11094 5332-5338 NN denotes tissue
T11095 5338-5339 -COMMA- denotes ,
T11096 5340-5343 CC denotes and
T11097 5344-5351 NN denotes defects
T11098 5352-5354 IN denotes in
T11099 5355-5358 DT denotes the
T11100 5359-5369 NN denotes production
T11101 5370-5372 IN denotes of
T11102 5373-5381 VB denotes switched
T11103 5382-5396 NN denotes immunoglobulin
T11104 5397-5405 NN denotes isotypes
T11105 5406-5407 -LRB- denotes [
T11106 5407-5409 CD denotes 17
T11107 5409-5410 -RRB- denotes ]
T11108 5410-5411 -COMMA- denotes ,
T11109 5412-5413 -LRB- denotes [
T11110 5413-5415 CD denotes 25
T11111 5415-5416 -RRB- denotes ]
T11112 5418-5421 DT denotes The
T11113 5422-5432 RB denotes apparently
T11114 5433-5441 JJ denotes intimate
T11115 5442-5452 JJ denotes functional
T11116 5453-5457 NN denotes link
T11117 5458-5465 IN denotes between
T11118 5466-5473 NN denotes SHARPIN
T11119 5474-5477 CC denotes and
T11120 5478-5482 NN denotes HOIP
T11121 5483-5491 RB denotes strongly
T11122 5492-5500 VB denotes suggests
T11123 5501-5505 IN denotes that
T11124 5506-5508 IN denotes at
T11125 5509-5514 JJ denotes least
T11126 5515-5519 NN denotes part
T11127 5520-5522 IN denotes of
T11128 5523-5526 DT denotes the
T11129 5527-5531 NN denotes cpdm
T11130 5532-5541 NN denotes phenotype
T11131 5542-5547 VB denotes stems
T11132 5548-5552 IN denotes from
T11133 5553-5560 NN denotes defects
T11134 5561-5563 IN denotes in
T11135 5564-5567 DT denotes the
T11136 5568-5578 NN denotes regulation
T11137 5579-5581 CC denotes or
T11138 5582-5590 NN denotes function
T11139 5591-5593 IN denotes of
T11140 5594-5598 NN denotes HOIP
T10266 486-489 DT denotes the
T10847 3899-3904 IN denotes while
R8010 T10199 T10198 arg1Of results,Our
R8011 T10199 T10200 arg1Of results,indicate
R8012 T10204 T10202 arg1Of HOIP,the
R8013 T10204 T10203 arg1Of HOIP,protein
R8014 T10204 T10205 arg1Of HOIP,is
R8015 T10204 T10206 arg1Of HOIP,critical
R8016 T10205 T10200 arg2Of is,indicate
R8017 T10205 T10201 arg1Of is,that
R8018 T10206 T10205 arg2Of critical,is
R8019 T10206 T10207 arg1Of critical,for
R8020 T10209 T10207 arg2Of signals,for
R8021 T10209 T10208 arg1Of signals,CD40-induced
R8022 T10209 T10210 arg1Of signals,that
R8023 T10209 T10211 arg1Of signals,regulate
R8024 T10214 T10211 arg2Of function,regulate
R8025 T10214 T10212 arg1Of function,B
R8026 T10214 T10213 arg1Of function,cell
R8027 T10216 T10215 arg1Of data,Our
R8028 T10216 T10217 arg1Of data,show
R8029 T10221 T10219 arg1Of responses,HOIP-dependent
R8030 T10221 T10220 arg1Of responses,cellular
R8031 T10221 T10222 arg1Of responses,include
R8032 T10222 T10217 arg2Of include,show
R8033 T10222 T10218 arg1Of include,that
R8034 T10224 T10222 arg2Of upregulation,include
R8035 T10224 T10223 arg1Of upregulation,CD40-mediated
R8036 T10224 T10225 arg1Of upregulation,of
R8037 T10227 T10228 arg1Of expression,and
R8038 T10228 T10225 arg2Of and,of
R8039 T10228 T10226 arg1Of and,CD80
R8040 T10228 T10230 arg1Of and,of
R8041 T10229 T10228 arg2Of synthesis,and
R8042 T10233 T10230 arg2Of transcripts,of
R8043 T10233 T10231 arg1Of transcripts,germline
R8044 T10233 T10232 arg1Of transcripts,RNA
R8045 T10233 T10234 arg1Of transcripts,from
R8046 T10239 T10234 arg2Of locus,from
R8047 T10239 T10235 arg1Of locus,the
R8048 T10239 T10236 arg1Of locus,immunoglobulin
R8049 T10239 T10237 arg1Of locus,heavy
R8050 T10239 T10238 arg1Of locus,chain
R8051 T10239 T10240 arg1Of locus,","
R8052 T10242 T10240 arg2Of events,","
R8053 T10242 T10241 arg1Of events,two
R8054 T10242 T10243 arg1Of events,that
R8055 T10242 T10244 arg1Of events,are
R8056 T10242 T10245 arg1Of events,important
R8057 T10245 T10244 arg2Of important,are
R8058 T10245 T10246 arg1Of important,for
R8059 T10250 T10246 arg2Of responses,for
R8060 T10250 T10247 arg1Of responses,T-cell-dependent
R8061 T10250 T10248 arg1Of responses,antibody-mediated
R8062 T10250 T10249 arg1Of responses,immune
R8063 T10254 T10251 arg2Of level,At
R8064 T10254 T10252 arg1Of level,the
R8065 T10254 T10253 arg1Of level,molecular
R8066 T10257 T10256 arg1Of data,our
R8067 T10257 T10258 arg1Of data,indicate
R8068 T10258 T10251 arg1Of indicate,At
R8069 T10258 T10255 arg1Of indicate,","
R8070 T10258 T10285 arg1Of indicate,to
R8071 T10261 T10260 arg1Of functions,HOIP
R8072 T10261 T10262 arg1Of functions,downstream
R8073 T10261 T10273 arg1Of functions,has
R8074 T10262 T10263 arg1Of downstream,of
R8075 T10264 T10263 arg2Of TRAF2,of
R8076 T10264 T10265 arg1Of TRAF2,in
R8077 T10269 T10267 arg1Of pathway,CD40
R8078 T10269 T10268 arg1Of pathway,signaling
R8079 T10269 T10270 arg1Of pathway,and
R8080 T10270 T10265 arg2Of and,in
R8081 T10270 T10266 arg1Of and,the
R8082 T10272 T10270 arg2Of HOIP,and
R8083 T10272 T10271 arg1Of HOIP,that
R8084 T10273 T10258 arg2Of has,indicate
R8085 T10273 T10259 arg1Of has,that
R8086 T10273 T10277 arg1Of has,in
R8087 T10276 T10273 arg2Of role,has
R8088 T10276 T10274 arg1Of role,a
R8089 T10276 T10275 arg1Of role,key
R8090 T10278 T10277 arg2Of promoting,in
R8091 T10280 T10278 arg2Of recruitment,promoting
R8092 T10280 T10279 arg1Of recruitment,the
R8093 T10280 T10281 arg1Of recruitment,of
R8094 T10284 T10281 arg2Of complex,of
R8095 T10284 T10282 arg1Of complex,the
R8096 T10284 T10283 arg1Of complex,IKK
R8097 T10286 T10285 arg2Of CD40,to
R8098 T10287 T10288 arg1Of Consistent,with
R8099 T10289 T10288 arg2Of this,with
R8100 T10292 T10291 arg1Of activation,CD40-induced
R8101 T10292 T10293 arg1Of activation,of
R8102 T10292 T10295 arg1Of activation,is
R8103 T10292 T10296 arg1Of activation,dependent
R8104 T10294 T10293 arg2Of NF-κB,of
R8105 T10295 T10287 arg1Of is,Consistent
R8106 T10295 T10290 arg1Of is,","
R8107 T10296 T10295 arg2Of dependent,is
R8108 T10296 T10297 arg1Of dependent,on
R8109 T10299 T10297 arg2Of presence,on
R8110 T10299 T10298 arg1Of presence,the
R8111 T10299 T10300 arg1Of presence,of
R8112 T10301 T10300 arg2Of HOIP,of
R8113 T10303 T10302 arg2Of addition,In
R8114 T10306 T10305 arg1Of data,our
R8115 T10306 T10307 arg1Of data,show
R8116 T10307 T10302 arg1Of show,In
R8117 T10307 T10304 arg1Of show,","
R8118 T10309 T10310 arg1Of HOIP,facilitates
R8119 T10310 T10307 arg2Of facilitates,show
R8120 T10310 T10308 arg1Of facilitates,that
R8121 T10310 T10315 arg1Of facilitates,in
R8122 T10312 T10310 arg2Of activation,facilitates
R8123 T10312 T10311 arg1Of activation,the
R8124 T10312 T10313 arg1Of activation,of
R8125 T10314 T10313 arg2Of JNK,of
R8126 T10316 T10315 arg2Of response,in
R8127 T10316 T10317 arg1Of response,to
R8128 T10319 T10317 arg2Of engagement,to
R8129 T10319 T10318 arg1Of engagement,CD40
R8130 T10323 T10322 arg1Of findings,our
R8131 T10323 T10324 arg1Of findings,provide
R8132 T10324 T10320 arg1Of provide,Together
R8133 T10324 T10321 arg1Of provide,","
R8134 T10325 T10324 arg2Of support,provide
R8135 T10325 T10326 arg1Of support,for
R8136 T10328 T10326 arg2Of conclusion,for
R8137 T10328 T10327 arg1Of conclusion,the
R8138 T10330 T10331 arg1Of HOIP,is
R8139 T10331 T10328 arg2Of is,conclusion
R8140 T10331 T10329 arg1Of is,that
R8141 T10334 T10331 arg2Of component,is
R8142 T10334 T10332 arg1Of component,a
R8143 T10334 T10333 arg1Of component,key
R8144 T10334 T10335 arg1Of component,of
R8145 T10339 T10335 arg2Of pathway,of
R8146 T10339 T10336 arg1Of pathway,the
R8147 T10339 T10337 arg1Of pathway,CD40
R8148 T10339 T10338 arg1Of pathway,signaling
R8149 T10342 T10340 arg2Of importance,Given
R8150 T10342 T10341 arg1Of importance,the
R8151 T10342 T10343 arg1Of importance,of
R8152 T10342 T10346 arg1Of importance,in
R8153 T10345 T10343 arg2Of signaling,of
R8154 T10345 T10344 arg1Of signaling,CD40
R8155 T10348 T10349 arg1Of cellular,and
R8156 T10350 T10349 arg2Of humoral,and
R8157 T10352 T10346 arg2Of responses,in
R8158 T10352 T10347 arg1Of responses,both
R8159 T10352 T10348 arg1Of responses,cellular
R8160 T10352 T10350 arg1Of responses,humoral
R8161 T10352 T10351 arg1Of responses,immune
R8162 T10355 T10354 arg1Of results,our
R8163 T10355 T10356 arg1Of results,indicate
R8164 T10356 T10340 arg1Of indicate,Given
R8165 T10356 T10353 arg1Of indicate,","
R8166 T10358 T10359 arg1Of HOIP,has
R8167 T10359 T10356 arg2Of has,indicate
R8168 T10359 T10357 arg1Of has,that
R8169 T10359 T10363 arg1Of has,in
R8170 T10362 T10359 arg2Of role,has
R8171 T10362 T10360 arg1Of role,a
R8172 T10362 T10361 arg1Of role,critical
R8173 T10365 T10363 arg2Of regulation,in
R8174 T10365 T10364 arg1Of regulation,the
R8175 T10365 T10366 arg1Of regulation,of
R8176 T10369 T10366 arg2Of system,of
R8177 T10369 T10367 arg1Of system,the
R8178 T10369 T10368 arg1Of system,immune
R8179 T10372 T10370 arg1Of properties,The
R8180 T10372 T10371 arg1Of properties,functional
R8181 T10372 T10373 arg1Of properties,of
R8182 T10372 T10375 arg1Of properties,have
R8183 T10372 T10377 arg1Of properties,been
R8184 T10372 T10379 arg2Of properties,characterized
R8185 T10374 T10373 arg2Of HOIP,of
R8186 T10379 T10375 arg2Of characterized,have
R8187 T10379 T10376 arg1Of characterized,only
R8188 T10379 T10377 arg2Of characterized,been
R8189 T10379 T10378 arg1Of characterized,partially
R8190 T10381 T10380 arg1Of studies,Initial
R8191 T10381 T10382 arg1Of studies,showed
R8192 T10384 T10385 arg1Of HOIP,and
R8193 T10385 T10390 arg1Of and,are
R8194 T10389 T10385 arg2Of HOIL-1,and
R8195 T10389 T10386 arg1Of HOIL-1,the
R8196 T10389 T10387 arg2Of HOIL-1,related
R8197 T10389 T10388 arg1Of HOIL-1,protein
R8198 T10390 T10382 arg2Of are,showed
R8199 T10390 T10383 arg1Of are,that
R8200 T10391 T10390 arg2Of components,are
R8201 T10391 T10392 arg1Of components,of
R8202 T10394 T10395 arg1Of large,(
R8203 T10397 T10395 arg2Of kDa,(
R8204 T10397 T10396 arg1Of kDa,∼600
R8205 T10398 T10395 arg3Of ),(
R8206 T10400 T10392 arg2Of complex,of
R8207 T10400 T10393 arg1Of complex,a
R8208 T10400 T10394 arg1Of complex,large
R8209 T10400 T10399 arg1Of complex,protein
R8210 T10400 T10401 arg1Of complex,capable
R8211 T10401 T10402 arg1Of capable,of
R8212 T10403 T10402 arg2Of synthesizing,of
R8213 T10406 T10403 arg2Of chains,synthesizing
R8214 T10406 T10404 arg1Of chains,linear
R8215 T10406 T10405 arg1Of chains,polyubiquitin
R8216 T10406 T10407 arg1Of chains,[
R8217 T10408 T10407 arg2Of 5,[
R8218 T10409 T10407 arg3Of ],[
R8219 T10411 T10410 arg1Of studies,Subsequent
R8220 T10411 T10412 arg1Of studies,showed
R8221 T10411 T10422 arg1Of studies,facilitate
R8222 T10412 T10421 arg1Of showed,and
R8223 T10416 T10414 arg1Of complex,a
R8224 T10416 T10415 arg1Of complex,HOIP-containing
R8225 T10416 T10417 arg1Of complex,can
R8226 T10416 T10418 arg1Of complex,interact
R8227 T10418 T10412 arg2Of interact,showed
R8228 T10418 T10413 arg1Of interact,that
R8229 T10418 T10417 arg2Of interact,can
R8230 T10418 T10419 arg1Of interact,with
R8231 T10420 T10419 arg2Of IKKγ,with
R8232 T10422 T10421 arg2Of facilitate,and
R8233 T10422 T10426 arg1Of facilitate,via
R8234 T10423 T10422 arg2Of activation,facilitate
R8235 T10423 T10424 arg1Of activation,of
R8236 T10425 T10424 arg2Of NF-κB,of
R8237 T10429 T10426 arg2Of pathway,via
R8238 T10429 T10427 arg1Of pathway,the
R8239 T10429 T10428 arg1Of pathway,canonical
R8240 T10429 T10430 arg1Of pathway,[
R8241 T10431 T10430 arg2Of 16,[
R8242 T10432 T10430 arg3Of ],[
R8243 T10434 T10433 arg1Of data,These
R8244 T10434 T10435 arg1Of data,","
R8245 T10434 T10436 arg2Of data,considered
R8246 T10434 T10441 arg1Of data,suggest
R8247 T10436 T10437 arg1Of considered,together
R8248 T10436 T10438 arg1Of considered,with
R8249 T10439 T10438 arg2Of ours,with
R8250 T10441 T10440 arg1Of suggest,","
R8251 T10445 T10443 arg1Of complex,a
R8252 T10445 T10444 arg1Of complex,HOIP-containing
R8253 T10445 T10446 arg1Of complex,mediates
R8254 T10446 T10441 arg2Of mediates,suggest
R8255 T10446 T10442 arg1Of mediates,that
R8256 T10447 T10446 arg2Of recruitment,mediates
R8257 T10447 T10448 arg1Of recruitment,of
R8258 T10447 T10450 arg1Of recruitment,to
R8259 T10449 T10448 arg2Of IKKγ,of
R8260 T10454 T10450 arg2Of complex,to
R8261 T10454 T10451 arg1Of complex,the
R8262 T10454 T10452 arg1Of complex,CD40
R8263 T10454 T10453 arg1Of complex,signaling
R8264 T10456 T10455 arg2Of addition,In
R8265 T10459 T10458 arg1Of HOIP,CD40-associated
R8266 T10459 T10460 arg1Of HOIP,could
R8267 T10459 T10461 arg1Of HOIP,play
R8268 T10461 T10455 arg1Of play,In
R8269 T10461 T10457 arg1Of play,","
R8270 T10461 T10460 arg2Of play,could
R8271 T10461 T10464 arg1Of play,in
R8272 T10463 T10461 arg2Of role,play
R8273 T10463 T10462 arg1Of role,a
R8274 T10465 T10464 arg2Of activating,in
R8275 T10465 T10467 arg1Of activating,after
R8276 T10465 T10474 arg1Of activating,[
R8277 T10466 T10465 arg2Of IKKγ,activating
R8278 T10469 T10467 arg2Of recruitment,after
R8279 T10469 T10468 arg1Of recruitment,its
R8280 T10469 T10470 arg1Of recruitment,to
R8281 T10473 T10470 arg2Of complex,to
R8282 T10473 T10471 arg1Of complex,the
R8283 T10473 T10472 arg1Of complex,signaling
R8284 T10475 T10474 arg2Of 16,[
R8285 T10476 T10474 arg3Of ],[
R8286 T10481 T10477 arg1Of forms,The
R8287 T10481 T10478 arg1Of forms,higher
R8288 T10481 T10479 arg1Of forms,molecular
R8289 T10481 T10480 arg1Of forms,weight
R8290 T10481 T10482 arg1Of forms,of
R8291 T10481 T10485 arg2Of forms,observed
R8292 T10481 T10489 arg1Of forms,would
R8293 T10481 T10490 arg1Of forms,be
R8294 T10481 T10491 arg1Of forms,consistent
R8295 T10483 T10482 arg2Of IKKγ,of
R8296 T10484 T10485 arg1Of we,observed
R8297 T10485 T10486 arg1Of observed,in
R8298 T10488 T10486 arg2Of immunoprecipitates,in
R8299 T10488 T10487 arg1Of immunoprecipitates,CD40
R8300 T10490 T10489 arg2Of be,would
R8301 T10491 T10490 arg2Of consistent,be
R8302 T10491 T10492 arg1Of consistent,with
R8303 T10494 T10492 arg2Of presence,with
R8304 T10494 T10493 arg1Of presence,the
R8305 T10494 T10495 arg1Of presence,of
R8306 T10497 T10495 arg2Of modifications,of
R8307 T10497 T10496 arg1Of modifications,post-transcriptional
R8308 T10497 T10498 arg1Of modifications,including
R8309 T10499 T10500 arg1Of phosphorylation,and
R8310 T10500 T10498 arg2Of and,including
R8311 T10500 T10502 arg1Of and,","
R8312 T10500 T10503 arg1Of and,which
R8313 T10500 T10504 arg1Of and,have
R8314 T10500 T10505 arg1Of and,been
R8315 T10500 T10506 arg2Of and,suggested
R8316 T10500 T10508 arg1Of and,reduce
R8317 T10500 T10510 arg1Of and,enhance
R8318 T10501 T10500 arg2Of ubiquitination,and
R8319 T10506 T10504 arg2Of suggested,have
R8320 T10506 T10505 arg2Of suggested,been
R8321 T10508 T10509 arg1Of reduce,or
R8322 T10509 T10506 arg3Of or,suggested
R8323 T10509 T10507 arg1Of or,to
R8324 T10509 T10518 arg1Of or,","
R8325 T10509 T10519 arg1Of or,[
R8326 T10510 T10509 arg2Of enhance,or
R8327 T10512 T10508 arg2Of activity,reduce
R8328 T10512 T10510 arg2Of activity,enhance
R8329 T10512 T10511 arg1Of activity,IKKγ
R8330 T10512 T10513 arg1Of activity,","
R8331 T10512 T10514 arg1Of activity,respectively
R8332 T10512 T10515 arg1Of activity,[
R8333 T10516 T10515 arg2Of 16,[
R8334 T10517 T10515 arg3Of ],[
R8335 T10520 T10519 arg2Of 17,[
R8336 T10521 T10519 arg3Of ],[
R8337 T10523 T10522 arg1Of mechanisms,The
R8338 T10523 T10524 arg2Of mechanisms,by
R8339 T10523 T10525 arg1Of mechanisms,which
R8340 T10523 T10536 arg2Of mechanisms,by
R8341 T10523 T10537 arg1Of mechanisms,which
R8342 T10523 T10543 arg1Of mechanisms,remain
R8343 T10523 T10544 arg1Of mechanisms,unclear
R8344 T10526 T10527 arg1Of HOIP,mediates
R8345 T10527 T10524 arg1Of mediates,by
R8346 T10527 T10535 arg1Of mediates,and
R8347 T10528 T10527 arg2Of recruitment,mediates
R8348 T10528 T10529 arg1Of recruitment,of
R8349 T10528 T10533 arg1Of recruitment,to
R8350 T10532 T10529 arg2Of complex,of
R8351 T10532 T10530 arg1Of complex,the
R8352 T10532 T10531 arg1Of complex,IKK
R8353 T10534 T10533 arg2Of CD40,to
R8354 T10538 T10539 arg1Of HOIP,is
R8355 T10538 T10540 arg2Of HOIP,recruited
R8356 T10540 T10535 arg2Of recruited,and
R8357 T10540 T10536 arg1Of recruited,by
R8358 T10540 T10539 arg2Of recruited,is
R8359 T10540 T10541 arg1Of recruited,to
R8360 T10542 T10541 arg2Of CD40,to
R8361 T10544 T10543 arg2Of unclear,remain
R8362 T10547 T10545 arg1Of study,A
R8363 T10547 T10546 arg1Of study,previous
R8364 T10547 T10548 arg1Of study,indicates
R8365 T10550 T10551 arg1Of HOIP,may
R8366 T10550 T10552 arg1Of HOIP,mediate
R8367 T10552 T10548 arg2Of mediate,indicates
R8368 T10552 T10549 arg1Of mediate,that
R8369 T10552 T10551 arg2Of mediate,may
R8370 T10552 T10562 arg1Of mediate,","
R8371 T10552 T10563 modOf mediate,suggesting
R8372 T10554 T10552 arg2Of contacts,mediate
R8373 T10554 T10553 arg1Of contacts,direct
R8374 T10554 T10555 arg1Of contacts,with
R8375 T10558 T10555 arg2Of complex,with
R8376 T10558 T10556 arg1Of complex,the
R8377 T10558 T10557 arg1Of complex,IKK
R8378 T10558 T10559 arg1Of complex,[
R8379 T10560 T10559 arg2Of 16,[
R8380 T10561 T10559 arg3Of ],[
R8381 T10565 T10566 arg1Of it,functions
R8382 T10566 T10563 arg2Of functions,suggesting
R8383 T10566 T10564 arg1Of functions,that
R8384 T10566 T10567 arg1Of functions,as
R8385 T10569 T10567 arg2Of adaptor,as
R8386 T10569 T10568 arg1Of adaptor,an
R8387 T10569 T10570 arg1Of adaptor,for
R8388 T10572 T10570 arg2Of recruitment,for
R8389 T10572 T10571 arg1Of recruitment,the
R8390 T10572 T10573 arg1Of recruitment,of
R8391 T10572 T10577 arg1Of recruitment,to
R8392 T10576 T10573 arg2Of complex,of
R8393 T10576 T10574 arg1Of complex,the
R8394 T10576 T10575 arg1Of complex,IKK
R8395 T10578 T10577 arg2Of CD40,to
R8396 T10584 T10581 arg1Of activity,the
R8397 T10584 T10582 arg1Of activity,ubiquitin
R8398 T10584 T10583 arg1Of activity,ligase
R8399 T10584 T10585 arg1Of activity,of
R8400 T10584 T10587 arg1Of activity,suggests
R8401 T10586 T10585 arg2Of HOIP,of
R8402 T10587 T10579 arg1Of suggests,However
R8403 T10587 T10580 arg1Of suggests,","
R8404 T10589 T10590 arg1Of it,is
R8405 T10589 T10591 arg1Of it,more
R8406 T10590 T10587 arg2Of is,suggests
R8407 T10590 T10588 arg1Of is,that
R8408 T10591 T10590 arg2Of more,is
R8409 T10591 T10592 arg1Of more,than
R8410 T10596 T10592 arg2Of molecule,than
R8411 T10596 T10593 arg1Of molecule,a
R8412 T10596 T10594 arg1Of molecule,simple
R8413 T10596 T10595 arg1Of molecule,adapter
R8414 T10598 T10599 arg1Of IKKγ,appears
R8415 T10598 T10600 arg1Of IKKγ,capable
R8416 T10598 T10602 arg1Of IKKγ,binding
R8417 T10599 T10597 arg2Of appears,As
R8418 T10599 T10608 arg1Of appears,","
R8419 T10599 T10609 arg1Of appears,[
R8420 T10600 T10599 arg2Of capable,appears
R8421 T10600 T10601 arg1Of capable,of
R8422 T10602 T10601 arg2Of binding,of
R8423 T10604 T10602 arg2Of polyubiquitin,binding
R8424 T10604 T10603 arg1Of polyubiquitin,linear
R8425 T10604 T10605 arg1Of polyubiquitin,[
R8426 T10606 T10605 arg2Of 18,[
R8427 T10607 T10605 arg3Of ],[
R8428 T10610 T10609 arg2Of 19,[
R8429 T10611 T10609 arg3Of ],[
R8430 T10614 T10597 arg1Of is,As
R8431 T10614 T10612 arg1Of is,","
R8432 T10615 T10614 arg2Of possible,is
R8433 T10617 T10618 arg1Of HOIP,directs
R8434 T10618 T10624 arg1Of directs,on
R8435 T10618 T10629 arg1Of directs,and
R8436 T10619 T10618 arg2Of formation,directs
R8437 T10619 T10620 arg1Of formation,of
R8438 T10623 T10620 arg2Of chains,of
R8439 T10623 T10621 arg1Of chains,linear
R8440 T10623 T10622 arg1Of chains,polyubiquitin
R8441 T10627 T10624 arg2Of factor,on
R8442 T10627 T10625 arg1Of factor,a
R8443 T10627 T10626 arg1Of factor,CD40-associated
R8444 T10629 T10613 arg1Of and,it
R8445 T10629 T10614 arg1Of and,is
R8446 T10629 T10615 arg1Of and,possible
R8447 T10629 T10616 arg1Of and,that
R8448 T10629 T10628 arg1Of and,","
R8449 T10630 T10631 arg1Of it,is
R8450 T10631 T10629 arg2Of is,and
R8451 T10633 T10631 arg2Of chains,is
R8452 T10633 T10632 arg1Of chains,these
R8453 T10633 T10634 arg1Of chains,that
R8454 T10633 T10635 arg1Of chains,serve
R8455 T10633 T10637 arg1Of chains,recruit
R8456 T10637 T10635 arg2Of recruit,serve
R8457 T10637 T10636 arg1Of recruit,to
R8458 T10638 T10637 arg2Of IKKγ,recruit
R8459 T10638 T10639 arg1Of IKKγ,to
R8460 T10643 T10639 arg2Of complex,to
R8461 T10643 T10640 arg1Of complex,the
R8462 T10643 T10641 arg1Of complex,CD40
R8463 T10643 T10642 arg1Of complex,signaling
R8464 T10646 T10644 arg1Of interactions,The
R8465 T10646 T10645 arg1Of interactions,molecular
R8466 T10646 T10647 arg1Of interactions,necessary
R8467 T10646 T10659 arg1Of interactions,remain
R8468 T10646 T10661 arg1Of interactions,be
R8469 T10646 T10663 arg2Of interactions,characterized
R8470 T10647 T10648 arg1Of necessary,for
R8471 T10647 T10653 arg1Of necessary,to
R8472 T10649 T10648 arg2Of recruitment,for
R8473 T10649 T10650 arg1Of recruitment,of
R8474 T10652 T10650 arg2Of itself,of
R8475 T10652 T10651 arg1Of itself,HOIP
R8476 T10657 T10653 arg2Of complex,to
R8477 T10657 T10654 arg1Of complex,the
R8478 T10657 T10655 arg1Of complex,CD40
R8479 T10657 T10656 arg1Of complex,signaling
R8480 T10659 T10658 arg1Of remain,also
R8481 T10663 T10659 arg2Of characterized,remain
R8482 T10663 T10660 arg1Of characterized,to
R8483 T10663 T10661 arg2Of characterized,be
R8484 T10663 T10662 arg1Of characterized,fully
R8485 T10664 T10666 arg1Of We,showed
R8486 T10666 T10665 arg1Of showed,previously
R8487 T10669 T10668 arg1Of recruitment,the
R8488 T10669 T10670 arg1Of recruitment,of
R8489 T10669 T10672 arg1Of recruitment,to
R8490 T10669 T10676 arg1Of recruitment,is
R8491 T10669 T10677 arg1Of recruitment,TRAF2-dependent
R8492 T10671 T10670 arg2Of HOIP,of
R8493 T10675 T10672 arg2Of complex,to
R8494 T10675 T10673 arg1Of complex,the
R8495 T10675 T10674 arg1Of complex,signaling
R8496 T10676 T10666 arg2Of is,showed
R8497 T10676 T10667 arg1Of is,that
R8498 T10676 T10678 arg1Of is,[
R8499 T10677 T10676 arg2Of TRAF2-dependent,is
R8500 T10679 T10678 arg2Of 8,[
R8501 T10680 T10678 arg3Of ],[
R8502 T10683 T10684 arg1Of TRAF2,and
R8503 T10684 T10687 arg1Of and,interact
R8504 T10685 T10684 arg2Of HOIP,and
R8505 T10687 T10686 arg1Of interact,directly
R8506 T10687 T10689 arg1Of interact,but
R8507 T10689 T10681 arg1Of but,Potentially
R8508 T10689 T10682 arg1Of but,","
R8509 T10689 T10688 arg1Of but,","
R8510 T10691 T10689 arg2Of is,but
R8511 T10692 T10691 arg2Of possible,is
R8512 T10697 T10694 arg1Of activity,the
R8513 T10697 T10695 arg1Of activity,ubiquitin
R8514 T10697 T10696 arg1Of activity,ligase
R8515 T10697 T10698 arg1Of activity,of
R8516 T10697 T10716 arg1Of activity,generates
R8517 T10699 T10698 arg2Of TRAF2,of
R8518 T10699 T10700 arg1Of TRAF2,[
R8519 T10699 T10703 arg1Of TRAF2,(
R8520 T10701 T10700 arg2Of 20,[
R8521 T10702 T10700 arg3Of ],[
R8522 T10706 T10703 arg2Of proteins,(
R8523 T10706 T10704 arg1Of proteins,or
R8524 T10706 T10705 arg1Of proteins,TRAF2-associated
R8525 T10706 T10707 arg1Of proteins,","
R8526 T10706 T10709 arg1Of proteins,as
R8527 T10706 T10712 arg1Of proteins,[
R8528 T10709 T10708 arg1Of as,such
R8529 T10711 T10709 arg2Of cIAPs,as
R8530 T10711 T10710 arg1Of cIAPs,the
R8531 T10713 T10712 arg2Of 21,[
R8532 T10714 T10712 arg3Of ],[
R8533 T10715 T10703 arg3Of ),(
R8534 T10716 T10690 arg1Of generates,it
R8535 T10716 T10691 arg1Of generates,is
R8536 T10716 T10692 arg1Of generates,possible
R8537 T10716 T10693 arg1Of generates,that
R8538 T10719 T10716 arg2Of chains,generates
R8539 T10719 T10717 arg1Of chains,K63-linked
R8540 T10719 T10718 arg1Of chains,polyubiquitin
R8541 T10719 T10720 arg2Of chains,to
R8542 T10719 T10721 arg1Of chains,which
R8543 T10722 T10723 arg1Of HOIP,can
R8544 T10751 T10749 arg2Of signaling,in
R8545 T10751 T10750 arg1Of signaling,CD40
R8546 T10722 T10724 arg1Of HOIP,bind
R8547 T10722 T10727 arg1Of HOIP,associate
R8548 T10724 T10723 arg2Of bind,can
R8549 T10754 T10755 arg1Of signals,and
R8550 T10755 T10753 arg1Of and,the
R8551 T10755 T10757 arg2Of and,tested
R8552 T10755 T10759 arg1Of and,are
R8553 T10755 T10760 arg1Of and,dependent
R8554 T10756 T10755 arg2Of functions,and
R8555 T10757 T10758 arg1Of tested,here
R8556 T10724 T10725 arg1Of bind,and
R8557 T10725 T10720 arg1Of and,to
R8558 T10727 T10725 arg2Of associate,and
R8559 T10759 T10736 arg1Of are,While
R8560 T10759 T10752 arg1Of are,","
R8561 T10760 T10759 arg2Of dependent,are
R8562 T10760 T10761 arg1Of dependent,upon
R8563 T10727 T10726 arg1Of associate,thus
R8564 T10762 T10765 arg1Of TRAF6,as
R8565 T10727 T10728 arg1Of associate,with
R8566 T10732 T10728 arg2Of complex,with
R8567 T10765 T10761 arg2Of as,upon
R8568 T10765 T10763 arg1Of as,as
R8569 T10765 T10764 arg1Of as,well
R8570 T10766 T10765 arg2Of TRAF2,as
R8571 T10769 T10767 arg2Of experiments,In
R8572 T10769 T10768 arg1Of experiments,previous
R8573 T10769 T10770 arg1Of experiments,with
R8574 T10773 T10770 arg2Of cells,with
R8575 T10773 T10771 arg1Of cells,TRAF-deficient
R8576 T10773 T10772 arg1Of cells,A20.2J
R8577 T10775 T10776 arg1Of we,found
R8578 T10776 T10767 arg1Of found,In
R8579 T10776 T10774 arg1Of found,","
R8580 T10732 T10729 arg1Of complex,the
R8581 T10732 T10730 arg1Of complex,CD40
R8582 T10732 T10731 arg1Of complex,signaling
R8583 T10779 T10778 arg1Of activation,the
R8584 T10732 T10733 arg1Of complex,[
R8585 T10779 T10780 arg1Of activation,of
R8586 T10779 T10782 arg1Of activation,by
R8587 T10779 T10784 arg1Of activation,could
R8588 T10779 T10785 arg1Of activation,be
R8589 T10779 T10786 arg2Of activation,mediated
R8590 T10781 T10780 arg2Of NF-κB,of
R8591 T10783 T10782 arg2Of CD40,by
R8592 T10734 T10733 arg2Of 22,[
R8593 T10786 T10776 arg2Of mediated,found
R8594 T10786 T10777 arg1Of mediated,that
R8595 T10786 T10784 arg2Of mediated,could
R8596 T10786 T10785 arg2Of mediated,be
R8597 T10786 T10792 arg1Of mediated,","
R8598 T10786 T10793 arg1Of mediated,while
R8599 T10789 T10790 arg1Of TRAF2,or
R8600 T10735 T10733 arg3Of ],[
R8601 T10790 T10786 arg1Of or,mediated
R8602 T10790 T10787 arg2Of or,by
R8603 T10790 T10788 arg1Of or,either
R8604 T10791 T10790 arg2Of TRAF6,or
R8605 T10739 T10737 arg1Of work,our
R8606 T10794 T10795 arg1Of activation,of
R8607 T10794 T10797 arg1Of activation,by
R8608 T10794 T10799 arg1Of activation,was
R8609 T10794 T10801 arg1Of activation,dependent
R8610 T10796 T10795 arg2Of JNK,of
R8611 T10798 T10797 arg2Of CD40,by
R8612 T10799 T10793 arg2Of was,while
R8613 T10799 T10805 arg1Of was,[
R8614 T10739 T10738 arg1Of work,previous
R8615 T10801 T10799 arg2Of dependent,was
R8616 T10801 T10800 arg1Of dependent,largely
R8617 T10801 T10802 arg1Of dependent,on
R8618 T10803 T10802 arg2Of TRAF6,on
R8619 T10803 T10804 arg1Of TRAF6,alone
R8620 T10739 T10740 arg1Of work,indicated
R8621 T10806 T10805 arg2Of 8,[
R8622 T10740 T10736 arg2Of indicated,While
R8623 T10807 T10805 arg3Of ],[
R8624 T10809 T10808 arg1Of deficiency,HOIP
R8625 T10809 T10810 arg1Of deficiency,compromises
R8626 T10743 T10742 arg1Of important,potentially
R8627 T10810 T10819 arg1Of compromises,","
R8628 T10744 T10740 arg2Of link,indicated
R8629 T10813 T10810 arg2Of activation,compromises
R8630 T10813 T10811 arg1Of activation,the
R8631 T10813 T10812 arg1Of activation,CD40-mediated
R8632 T10813 T10814 arg1Of activation,of
R8633 T10744 T10741 arg1Of link,a
R8634 T10816 T10817 arg1Of NF-κB,and
R8635 T10744 T10743 arg1Of link,important
R8636 T10817 T10814 arg2Of and,of
R8637 T10817 T10815 arg1Of and,both
R8638 T10744 T10745 arg1Of link,between
R8639 T10818 T10817 arg2Of JNK,and
R8640 T10746 T10747 arg1Of TRAF2,and
R8641 T10820 T10810 arg3Of indicating,compromises
R8642 T10747 T10745 arg2Of and,between
R8643 T10822 T10823 arg2Of signals,mediated
R8644 T10822 T10830 arg1Of signals,pass
R8645 T10747 T10749 arg1Of and,in
R8646 T10748 T10747 arg2Of HOIP,and
R8647 T10826 T10827 arg1Of TRAF2,and
R8648 T10827 T10823 arg1Of and,mediated
R8649 T10827 T10824 arg2Of and,by
R8650 T10827 T10825 arg1Of and,both
R8651 T10828 T10827 arg2Of TRAF6,and
R8652 T10848 T10847 arg2Of TRAF6-dependent,while
R8653 T10830 T10820 arg2Of pass,indicating
R8654 T10830 T10821 arg1Of pass,that
R8655 T10830 T10829 arg1Of pass,likely
R8656 T10830 T10831 arg1Of pass,through
R8657 T10832 T10831 arg2Of HOIP,through
R8658 T10852 T10837 arg2Of compromised,demonstrated
R8659 T10835 T10833 arg1Of work,Our
R8660 T10835 T10834 arg1Of work,previous
R8661 T10835 T10837 arg1Of work,demonstrated
R8662 T10837 T10836 arg1Of demonstrated,also
R8663 T10841 T10839 arg1Of activation,the
R8664 T10841 T10840 arg1Of activation,CD40-mediated
R8665 T10841 T10842 arg1Of activation,of
R8666 T10841 T10850 arg1Of activation,was
R8667 T10841 T10852 arg2Of activation,compromised
R8668 T10843 T10844 arg1Of NF-κB,and
R8669 T10844 T10842 arg2Of and,of
R8670 T10845 T10844 arg2Of JNK,and
R8671 T10852 T10838 arg1Of compromised,that
R8672 T10852 T10846 arg1Of compromised,","
R8673 T10852 T10847 arg1Of compromised,while
R8674 T10852 T10849 arg1Of compromised,","
R8675 T10852 T10850 arg2Of compromised,was
R8676 T10852 T10851 arg1Of compromised,not
R8677 T10852 T10880 arg1Of compromised,in
R8678 T10852 T10882 arg1Of compromised,[
R8679 T10855 T10854 arg1Of disruption,the
R8680 T10855 T10856 arg1Of disruption,of
R8681 T10855 T10862 arg1Of disruption,in
R8682 T10855 T10868 arg1Of disruption,or
R8683 T10859 T10856 arg2Of site,of
R8684 T10944 T10942 arg2Of results,","
R8685 T10944 T10943 arg1Of results,our
R8686 T10945 T10934 arg1Of and,Although
R8687 T10946 T10947 arg1Of those,of
R8688 T10946 T10953 arg1Of those,","
R8689 T10946 T10954 arg1Of those,[
R8690 T10946 T10957 arg1Of those,support
R8691 T10949 T10947 arg2Of groups,of
R8692 T10949 T10948 arg1Of groups,other
R8693 T10949 T10950 arg1Of groups,[
R8694 T10951 T10950 arg2Of 16,[
R8695 T10859 T10857 arg1Of site,the
R8696 T10952 T10950 arg3Of ],[
R8697 T10859 T10858 arg1Of site,binding
R8698 T10859 T10860 arg1Of site,for
R8699 T10955 T10954 arg2Of 22,[
R8700 T10861 T10860 arg2Of TRAF6,for
R8701 T10956 T10954 arg3Of ],[
R8702 T10957 T10945 arg2Of support,and
R8703 T10959 T10957 arg2Of possibility,support
R8704 T10959 T10958 arg1Of possibility,the
R8705 T10865 T10862 arg2Of domain,in
R8706 T10961 T10962 arg1Of HOIP,is
R8707 T10961 T10963 arg1Of HOIP,important
R8708 T10962 T10959 arg2Of is,possibility
R8709 T10962 T10960 arg1Of is,that
R8710 T10963 T10962 arg2Of important,is
R8711 T10963 T10964 arg1Of important,in
R8712 T10865 T10863 arg1Of domain,the
R8713 T10865 T10864 arg1Of domain,cytoplasmic
R8714 T10865 T10866 arg1Of domain,of
R8715 T10967 T10964 arg2Of pathways,in
R8716 T10967 T10965 arg1Of pathways,many
R8717 T10967 T10966 arg1Of pathways,signaling
R8718 T10967 T10968 arg2Of pathways,in
R8719 T10967 T10969 arg1Of pathways,which
R8720 T10967 T10975 arg1Of pathways,","
R8721 T10967 T10976 arg1Of pathways,including
R8722 T10970 T10971 arg1Of TRAF2,or
R8723 T10867 T10866 arg2Of CD40,of
R8724 T10971 T10973 arg1Of or,are
R8725 T10971 T10974 arg2Of or,involved
R8726 T10972 T10971 arg2Of TRAF6,or
R8727 T10974 T10968 arg1Of involved,in
R8728 T10974 T10973 arg2Of involved,are
R8729 T10868 T10852 arg1Of or,compromised
R8730 T10977 T10976 arg2Of those,including
R8731 T10977 T10978 arg2Of those,associated
R8732 T10868 T10853 arg2Of or,by
R8733 T10978 T10979 arg1Of associated,with
R8734 T10869 T10868 arg2Of deletion,or
R8735 T10981 T10979 arg2Of members,with
R8736 T10981 T10980 arg1Of members,various
R8737 T10869 T10870 arg1Of deletion,of
R8738 T10981 T10982 arg1Of members,of
R8739 T10874 T10870 arg2Of domain,of
R8740 T10986 T10983 arg1Of superfamily,the
R8741 T10986 T10984 arg1Of superfamily,TNF
R8742 T10986 T10985 arg1Of superfamily,receptor
R8743 T10986 T10987 arg1Of superfamily,and
R8744 T10987 T10982 arg2Of and,of
R8745 T10990 T10987 arg2Of receptors,and
R8746 T10990 T10988 arg1Of receptors,the
R8747 T10990 T10989 arg1Of receptors,Toll-like
R8748 T10874 T10871 arg1Of domain,the
R8749 T10874 T10872 arg1Of domain,receptor
R8750 T10993 T10991 arg1Of importance,The
R8751 T10993 T10992 arg1Of importance,potential
R8752 T10993 T10994 arg1Of importance,of
R8753 T10993 T10996 arg1Of importance,in
R8754 T10993 T11003 arg1Of importance,is
R8755 T10993 T11005 arg2Of importance,supported
R8756 T10995 T10994 arg2Of HOIP,of
R8757 T10874 T10873 arg1Of domain,binding
R8758 T10874 T10875 arg1Of domain,(
R8759 T10878 T10875 arg2Of domain,(
R8760 T10998 T10997 arg1Of function,immune
R8761 T10998 T10999 arg1Of function,and
R8762 T10999 T10996 arg2Of and,in
R8763 T11002 T10999 arg2Of signaling,and
R8764 T11002 T11000 arg1Of signaling,TNFR
R8765 T11002 T11001 arg1Of signaling,family
R8766 T10878 T10876 arg1Of domain,the
R8767 T11005 T11003 arg2Of supported,is
R8768 T11005 T11004 arg1Of supported,further
R8769 T11005 T11006 arg1Of supported,by
R8770 T10878 T10877 arg1Of domain,TRAF-C
R8771 T11009 T11006 arg2Of discovery,by
R8772 T11009 T11007 arg1Of discovery,the
R8773 T11009 T11008 arg1Of discovery,recent
R8774 T10879 T10875 arg3Of ),(
R8775 T11011 T11012 arg1Of HOIP,interacts
R8776 T11012 T11009 arg2Of interacts,discovery
R8777 T11012 T11010 arg1Of interacts,that
R8778 T11012 T11013 arg1Of interacts,with
R8779 T10881 T10880 arg2Of TRAF6,in
R8780 T11015 T11013 arg2Of protein,with
R8781 T11015 T11014 arg1Of protein,a
R8782 T11015 T11016 arg2Of protein,known
R8783 T11016 T11017 arg1Of known,as
R8784 T10883 T10882 arg2Of 8,[
R8785 T11018 T11017 arg2Of SHARPIN,as
R8786 T11018 T11019 arg1Of SHARPIN,(
R8787 T11018 T11029 arg1Of SHARPIN,","
R8788 T11018 T11030 arg1Of SHARPIN,which
R8789 T11018 T11031 arg1Of SHARPIN,appears
R8790 T11018 T11032 arg1Of SHARPIN,capable
R8791 T11018 T11034 arg1Of SHARPIN,working
R8792 T11024 T11019 arg2Of protein,(
R8793 T11024 T11020 arg1Of protein,SHANK-associated
R8794 T11024 T11021 arg1Of protein,RH
R8795 T11024 T11022 arg1Of protein,domain
R8796 T11024 T11023 arg1Of protein,interacting
R8797 T11024 T11025 arg1Of protein,in
R8798 T10884 T10882 arg3Of ],[
R8799 T11027 T11025 arg2Of density,in
R8800 T11027 T11026 arg1Of density,postsynaptic
R8801 T11028 T11019 arg3Of ),(
R8802 T10886 T10885 arg1Of observations,These
R8803 T11032 T11031 arg2Of capable,appears
R8804 T11032 T11033 arg1Of capable,of
R8805 T11034 T11033 arg2Of working,of
R8806 T11034 T11035 arg1Of working,together
R8807 T11034 T11036 arg1Of working,with
R8808 T10886 T10887 arg1Of observations,indicate
R8809 T10889 T10890 arg1Of TRAF6,need
R8810 T11037 T11038 arg1Of HOIP,and
R8811 T10889 T10893 arg1Of TRAF6,bind
R8812 T11038 T11036 arg2Of and,with
R8813 T11039 T11038 arg2Of HOIL,and
R8814 T11039 T11040 modOf HOIL,to
R8815 T10889 T10898 arg1Of TRAF6,mediate
R8816 T10890 T10887 arg2Of need,indicate
R8817 T10890 T10888 arg1Of need,that
R8818 T10890 T10891 arg1Of need,not
R8819 T11041 T11040 arg1Of mediate,to
R8820 T11041 T11050 arg1Of mediate,","
R8821 T11041 T11051 arg1Of mediate,[
R8822 T11041 T11054 arg1Of mediate,","
R8823 T11041 T11055 arg1Of mediate,[
R8824 T11043 T11041 arg2Of assembly,mediate
R8825 T11043 T11042 arg1Of assembly,the
R8826 T10890 T10892 arg1Of need,directly
R8827 T10893 T10890 arg2Of bind,need
R8828 T11043 T11044 arg1Of assembly,of
R8829 T11046 T11044 arg2Of polyubiquitin,of
R8830 T11046 T11045 arg1Of polyubiquitin,linear
R8831 T11046 T11047 arg1Of polyubiquitin,[
R8832 T10893 T10895 arg1Of bind,in
R8833 T11048 T11047 arg2Of 14,[
R8834 T10893 T10901 arg1Of bind,","
R8835 T10893 T10902 modOf bind,suggesting
R8836 T11049 T11047 arg3Of ],[
R8837 T10894 T10893 arg2Of CD40,bind
R8838 T11052 T11051 arg2Of 23,[
R8839 T11053 T11051 arg3Of ],[
R8840 T10896 T10895 arg2Of order,in
R8841 T11056 T11055 arg2Of 24,[
R8842 T11057 T11055 arg3Of ],[
R8843 T10898 T10895 arg3Of mediate,in
R8844 T11060 T11061 arg1Of mice,with
R8845 T11060 T11065 arg1Of mice,in
R8846 T11060 T11079 arg1Of mice,exhibit
R8847 T10898 T10897 arg1Of mediate,to
R8848 T10900 T10898 arg2Of signals,mediate
R8849 T11064 T11061 arg2Of mutation,with
R8850 T11064 T11062 arg1Of mutation,a
R8851 T11064 T11063 arg1Of mutation,spontaneous
R8852 T11067 T11065 arg2Of gene,in
R8853 T11067 T11066 arg1Of gene,the
R8854 T11067 T11068 arg1Of gene,encoding
R8855 T10900 T10899 arg1Of signals,certain
R8856 T11069 T11068 arg2Of SHARPIN,encoding
R8857 T11069 T11070 arg1Of SHARPIN,(
R8858 T10904 T10902 arg2Of assembly,suggesting
R8859 T11075 T11074 arg2Of cpdm,(
R8860 T11076 T11074 arg3Of ),(
R8861 T10904 T10903 arg1Of assembly,the
R8862 T11077 T11070 arg2Of mice,(
R8863 T11077 T11071 arg1Of mice,chronic
R8864 T11077 T11072 arg1Of mice,proliferative
R8865 T11077 T11073 arg1Of mice,dermatitis
R8866 T11077 T11074 arg1Of mice,(
R8867 T11078 T11070 arg3Of ),(
R8868 T10904 T10905 arg1Of assembly,of
R8869 T11079 T11058 arg1Of exhibit,Interestingly
R8870 T11079 T11059 arg1Of exhibit,","
R8871 T11081 T11080 arg1Of inflammation,chronic
R8872 T11081 T11082 arg1Of inflammation,of
R8873 T11081 T11088 arg1Of inflammation,","
R8874 T10904 T10911 arg2Of assembly,associated
R8875 T11084 T11085 arg1Of skin,and
R8876 T10908 T10905 arg2Of complex,of
R8877 T11085 T11082 arg2Of and,of
R8878 T11085 T11083 arg1Of and,the
R8879 T11087 T11085 arg2Of organs,and
R8880 T11087 T11086 arg1Of organs,internal
R8881 T11088 T11096 arg1Of ",",and
R8882 T11090 T11088 arg2Of development,","
R8883 T11090 T11089 arg1Of development,defective
R8884 T11090 T11091 arg1Of development,of
R8885 T10908 T10906 arg1Of complex,a
R8886 T10908 T10907 arg1Of complex,signaling
R8887 T11094 T11091 arg2Of tissue,of
R8888 T11094 T11092 arg1Of tissue,secondary
R8889 T11094 T11093 arg1Of tissue,lymphoid
R8890 T10911 T10909 arg1Of associated,not
R8891 T11096 T11079 arg2Of and,exhibit
R8892 T11096 T11095 arg1Of and,","
R8893 T11097 T11096 arg2Of defects,and
R8894 T11097 T11098 arg1Of defects,in
R8895 T11100 T11098 arg2Of production,in
R8896 T11100 T11099 arg1Of production,the
R8897 T11100 T11101 arg1Of production,of
R8898 T10911 T10910 arg1Of associated,directly
R8899 T10911 T10912 arg1Of associated,with
R8900 T11104 T11101 arg2Of isotypes,of
R8901 T11104 T11102 arg2Of isotypes,switched
R8902 T11104 T11103 arg1Of isotypes,immunoglobulin
R8903 T11104 T11105 arg1Of isotypes,[
R8904 T11104 T11108 arg1Of isotypes,","
R8905 T11104 T11109 arg1Of isotypes,[
R8906 T10914 T10912 arg2Of receptor,with
R8907 T11106 T11105 arg2Of 17,[
R8908 T11107 T11105 arg3Of ],[
R8909 T11110 T11109 arg2Of 25,[
R8910 T11111 T11109 arg3Of ],[
R8911 T10914 T10913 arg1Of receptor,the
R8912 T10918 T10916 arg1Of complex,such
R8913 T11114 T11113 arg1Of intimate,apparently
R8914 T11116 T11112 arg1Of link,The
R8915 T11116 T11114 arg1Of link,intimate
R8916 T11116 T11115 arg1Of link,functional
R8917 T11116 T11117 arg1Of link,between
R8918 T11116 T11122 arg1Of link,suggests
R8919 T10918 T10917 arg1Of complex,a
R8920 T11118 T11119 arg1Of SHARPIN,and
R8921 T11119 T11117 arg2Of and,between
R8922 T11120 T11119 arg2Of HOIP,and
R8923 T10918 T10919 arg1Of complex,exists
R8924 T10919 T10915 arg2Of exists,If
R8925 T11122 T11121 arg1Of suggests,strongly
R8926 T10922 T10921 arg1Of results,our
R8927 T11125 T11124 arg1Of least,at
R8928 T11126 T11125 arg1Of part,least
R8929 T11126 T11127 arg1Of part,of
R8930 T11126 T11131 arg1Of part,stems
R8931 T11130 T11127 arg2Of phenotype,of
R8932 T10922 T10923 arg1Of results,indicate
R8933 T11130 T11128 arg1Of phenotype,the
R8934 T11130 T11129 arg1Of phenotype,cpdm
R8935 T11131 T11122 arg2Of stems,suggests
R8936 T11131 T11123 arg1Of stems,that
R8937 T11131 T11132 arg1Of stems,from
R8938 T10923 T10915 arg1Of indicate,If
R8939 T11133 T11132 arg2Of defects,from
R8940 T11133 T11134 arg1Of defects,in
R8941 T10923 T10920 arg1Of indicate,","
R8942 T11136 T11137 arg1Of regulation,or
R8943 T10926 T10925 arg1Of absence,the
R8944 T10926 T10927 arg1Of absence,of
R8945 T11137 T11134 arg2Of or,in
R8946 T11137 T11135 arg1Of or,the
R8947 T11137 T11139 arg1Of or,of
R8948 T11138 T11137 arg2Of function,or
R8949 T10926 T10929 arg1Of absence,compromises
R8950 T10928 T10927 arg2Of HOIP,of
R8951 T11140 T11139 arg2Of HOIP,of
R8952 T10929 T10923 arg2Of compromises,indicate
R8953 T10929 T10924 arg1Of compromises,that
R8954 T10929 T10933 arg1Of compromises,well
R8955 T10931 T10929 arg2Of function,compromises
R8956 T10931 T10930 arg1Of function,its
R8957 T10933 T10932 arg1Of well,as
R8958 T10936 T10935 arg1Of experiments,the
R8960 T10936 T10937 arg2Of experiments,presented
R8961 T10936 T10939 arg1Of experiments,focus
R8963 T10937 T10938 arg1Of presented,here
R8965 T10939 T10940 arg1Of focus,on
R8967 T10939 T10945 arg1Of focus,and
R8968 T10941 T10942 arg1Of CD40,","
R8969 T10942 T10940 arg2Of ",",on

2_test

Id Subject Object Predicate Lexical cue
21829693-17006537-89653774 1334-1335 17006537 denotes 5
21829693-19136968-89653775 1480-1482 19136968 denotes 16
21829693-19136968-89653776 1746-1748 19136968 denotes 16
21829693-19136968-89653777 2030-2032 19136968 denotes 16
21829693-16987664-89653778 2036-2038 16987664 denotes 17
21829693-19136968-89653779 2260-2262 19136968 denotes 16
21829693-19422324-89653780 2517-2519 19422324 denotes 18
21829693-19303852-89653781 2523-2525 19303852 denotes 19
21829693-17878362-89653782 2944-2945 17878362 denotes 8
21829693-11057907-89653783 3059-3061 11057907 denotes 20
21829693-19680262-89653784 3113-3115 19680262 denotes 21
21829693-20005846-89653785 3235-3237 20005846 denotes 22
21829693-17878362-89653786 3644-3645 17878362 denotes 8
21829693-17878362-89653787 4097-4098 17878362 denotes 8
21829693-19136968-89653788 4495-4497 19136968 denotes 16
21829693-20005846-89653789 4501-4503 20005846 denotes 22
21829693-21455173-89653790 5085-5087 21455173 denotes 14
21829693-21455181-89653791 5091-5093 21455181 denotes 23
21829693-21455180-89653792 5097-5099 21455180 denotes 24
21829693-16987664-89653793 5407-5409 16987664 denotes 17
21829693-11971901-89653794 5413-5415 11971901 denotes 25
T28187 1334-1335 17006537 denotes 5
T28161 1480-1482 19136968 denotes 16
T55334 1746-1748 19136968 denotes 16
T95367 2030-2032 19136968 denotes 16
T4079 2036-2038 16987664 denotes 17
T25061 2260-2262 19136968 denotes 16
T3498 2517-2519 19422324 denotes 18
T25480 2523-2525 19303852 denotes 19
T25070 2944-2945 17878362 denotes 8
T78842 3059-3061 11057907 denotes 20
T23692 3113-3115 19680262 denotes 21
T56922 3235-3237 20005846 denotes 22
T58585 3644-3645 17878362 denotes 8
T52073 4097-4098 17878362 denotes 8
T44642 4495-4497 19136968 denotes 16
T44865 4501-4503 20005846 denotes 22
T55885 5085-5087 21455173 denotes 14
T81514 5091-5093 21455181 denotes 23
T53286 5097-5099 21455180 denotes 24
T24635 5407-5409 16987664 denotes 17
T45148 5413-5415 11971901 denotes 25

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T9222 11-14 PRP$ denotes Our
T9223 15-22 NNS denotes results
T9224 23-31 VBP denotes indicate
T9225 32-36 IN denotes that
T9226 37-40 DT denotes the
T9227 41-48 NN denotes protein
T9228 49-53 NNP denotes HOIP
T9229 54-56 VBZ denotes is
T9230 57-65 JJ denotes critical
T9231 66-69 IN denotes for
T9232 70-82 JJ denotes CD40-induced
T9233 83-90 NNS denotes signals
T9234 91-95 WDT denotes that
T9235 96-104 VBP denotes regulate
T9236 105-106 NNP denotes B
T9237 107-111 NN denotes cell
T9238 112-120 NN denotes function
T9239 120-121 . denotes .
T9240 122-125 PRP$ denotes Our
T9241 126-130 NNS denotes data
T9242 131-135 VBP denotes show
T9243 136-140 IN denotes that
T9244 141-155 JJ denotes HOIP-dependent
T9245 156-164 JJ denotes cellular
T9246 165-174 NNS denotes responses
T9247 175-182 VBP denotes include
T9248 183-196 JJ denotes CD40-mediated
T9249 197-209 NN denotes upregulation
T9250 210-212 IN denotes of
T9251 213-217 CD denotes CD80
T9252 218-228 NN denotes expression
T9253 229-232 CC denotes and
T9254 233-242 NN denotes synthesis
T9255 243-245 IN denotes of
T9256 246-254 NN denotes germline
T9257 255-258 NNP denotes RNA
T9258 259-270 NNS denotes transcripts
T9259 271-275 IN denotes from
T9260 276-279 DT denotes the
T9261 280-294 NN denotes immunoglobulin
T9262 295-300 JJ denotes heavy
T9263 301-306 NN denotes chain
T9264 307-312 NN denotes locus
T9265 312-313 , denotes ,
T9266 314-317 CD denotes two
T9267 318-324 NNS denotes events
T9268 325-329 WDT denotes that
T9269 330-333 VBP denotes are
T9270 334-343 JJ denotes important
T9271 344-347 IN denotes for
T9272 348-364 JJ denotes T-cell-dependent
T9273 365-382 JJ denotes antibody-mediated
T9274 383-389 JJ denotes immune
T9275 390-399 NNS denotes responses
T9276 399-400 . denotes .
T9277 401-403 IN denotes At
T9278 404-407 DT denotes the
T9279 408-417 JJ denotes molecular
T9280 418-423 NN denotes level
T9281 423-424 , denotes ,
T9282 425-428 PRP$ denotes our
T9283 429-433 NNS denotes data
T9284 434-442 VBP denotes indicate
T9285 443-447 IN denotes that
T9286 448-452 NNP denotes HOIP
T9287 453-462 NNS denotes functions
T9288 463-473 JJ denotes downstream
T9289 474-476 IN denotes of
T9290 477-482 CD denotes TRAF2
T9291 483-485 IN denotes in
T9292 486-489 DT denotes the
T9293 490-494 NNP denotes CD40
T9294 495-504 VBG denotes signaling
T9295 505-512 NN denotes pathway
T9296 513-516 CC denotes and
T9297 517-521 IN denotes that
T9298 522-526 NNP denotes HOIP
T9299 527-530 VBZ denotes has
T9300 531-532 DT denotes a
T9301 533-536 JJ denotes key
T9302 537-541 NN denotes role
T9303 542-544 IN denotes in
T9304 545-554 VBG denotes promoting
T9305 555-558 DT denotes the
T9306 559-570 NN denotes recruitment
T9307 571-573 IN denotes of
T9308 574-577 DT denotes the
T9309 578-581 NNP denotes IKK
T9310 582-589 NN denotes complex
T9311 590-592 TO denotes to
T9312 593-597 NNP denotes CD40
T9313 597-598 . denotes .
T9314 599-609 JJ denotes Consistent
T9315 610-614 IN denotes with
T9316 615-619 DT denotes this
T9317 619-620 , denotes ,
T9318 621-633 JJ denotes CD40-induced
T9319 634-644 NN denotes activation
T9320 645-647 IN denotes of
T9321 648-653 NNP denotes NF-κB
T9322 654-656 VBZ denotes is
T9323 657-666 JJ denotes dependent
T9324 667-669 IN denotes on
T9325 670-673 DT denotes the
T9326 674-682 NN denotes presence
T9327 683-685 IN denotes of
T9328 686-690 NNP denotes HOIP
T9329 690-691 . denotes .
T9330 692-694 IN denotes In
T9331 695-703 NN denotes addition
T9332 703-704 , denotes ,
T9333 705-708 PRP$ denotes our
T9334 709-713 NNS denotes data
T9335 714-718 VBP denotes show
T9336 719-723 IN denotes that
T9337 724-728 NNP denotes HOIP
T9338 729-740 VBZ denotes facilitates
T9339 741-744 DT denotes the
T9340 745-755 NN denotes activation
T9341 756-758 IN denotes of
T9342 759-762 NNP denotes JNK
T9343 763-765 IN denotes in
T9344 766-774 NN denotes response
T9345 775-777 TO denotes to
T9346 778-782 CD denotes CD40
T9347 783-793 NN denotes engagement
T9348 793-794 . denotes .
T9349 795-803 RB denotes Together
T9350 803-804 , denotes ,
T9351 805-808 PRP$ denotes our
T9352 809-817 NNS denotes findings
T9353 818-825 VBP denotes provide
T9354 826-833 NN denotes support
T9355 834-837 IN denotes for
T9356 838-841 DT denotes the
T9357 842-852 NN denotes conclusion
T9358 853-857 WDT denotes that
T9359 858-862 NNP denotes HOIP
T9360 863-865 VBZ denotes is
T9361 866-867 DT denotes a
T9362 868-871 JJ denotes key
T9363 872-881 NN denotes component
T9364 882-884 IN denotes of
T9365 885-888 DT denotes the
T9366 889-893 NNP denotes CD40
T9367 894-903 VBG denotes signaling
T9368 904-911 NN denotes pathway
T9369 911-912 . denotes .
T9370 913-918 VBN denotes Given
T9371 919-922 DT denotes the
T9372 923-933 NN denotes importance
T9373 934-936 IN denotes of
T9374 937-941 NNP denotes CD40
T9375 942-951 VBG denotes signaling
T9376 952-954 IN denotes in
T9377 955-959 DT denotes both
T9378 960-968 JJ denotes cellular
T9379 969-972 CC denotes and
T9380 973-980 JJ denotes humoral
T9381 981-987 JJ denotes immune
T9382 988-997 NNS denotes responses
T9383 997-998 , denotes ,
T9384 999-1002 PRP$ denotes our
T9385 1003-1010 NNS denotes results
T9386 1011-1019 VBP denotes indicate
T9387 1020-1024 IN denotes that
T9388 1025-1029 NNP denotes HOIP
T9389 1030-1033 VBZ denotes has
T9390 1034-1035 DT denotes a
T9391 1036-1044 JJ denotes critical
T9392 1045-1049 NN denotes role
T9393 1050-1052 IN denotes in
T9394 1053-1056 DT denotes the
T9395 1057-1067 NN denotes regulation
T9396 1068-1070 IN denotes of
T9397 1071-1074 DT denotes the
T9398 1075-1081 JJ denotes immune
T9399 1082-1088 NN denotes system
T9400 1088-1089 . denotes .
T9401 1090-1093 DT denotes The
T9402 1094-1104 JJ denotes functional
T9403 1105-1115 NNS denotes properties
T9404 1116-1118 IN denotes of
T9405 1119-1123 NNP denotes HOIP
T9406 1124-1128 VBP denotes have
T9407 1129-1133 RB denotes only
T9408 1134-1138 VBN denotes been
T9409 1139-1148 RB denotes partially
T9410 1149-1162 VBN denotes characterized
T9411 1162-1163 . denotes .
T9412 1164-1171 JJ denotes Initial
T9413 1172-1179 NNS denotes studies
T9414 1180-1186 VBD denotes showed
T9415 1187-1191 IN denotes that
T9416 1192-1196 NNP denotes HOIP
T9417 1197-1200 CC denotes and
T9418 1201-1204 DT denotes the
T9419 1205-1212 JJ denotes related
T9420 1213-1220 NN denotes protein
T9421 1221-1227 NN denotes HOIL-1
T9422 1228-1231 VBP denotes are
T9423 1232-1242 NNS denotes components
T9424 1243-1245 IN denotes of
T9425 1246-1247 DT denotes a
T9426 1248-1253 JJ denotes large
T9427 1254-1255 -LRB- denotes (
T9428 1255-1256 FW denotes ∼
T9429 1256-1259 CD denotes 600
T9430 1260-1263 NN denotes kDa
T9431 1263-1264 -RRB- denotes )
T9432 1265-1272 NN denotes protein
T9433 1273-1280 JJ denotes complex
T9434 1281-1288 JJ denotes capable
T9435 1289-1291 IN denotes of
T9436 1292-1304 VBG denotes synthesizing
T9437 1305-1311 JJ denotes linear
T9438 1312-1325 NN denotes polyubiquitin
T9439 1326-1332 NNS denotes chains
T9440 1333-1334 VBP denotes [
T9441 1334-1335 CD denotes 5
T9442 1335-1336 NNP denotes ]
T9443 1336-1337 . denotes .
T9444 1338-1348 JJ denotes Subsequent
T9445 1349-1356 NNS denotes studies
T9446 1357-1363 VBD denotes showed
T9447 1364-1368 IN denotes that
T9448 1369-1370 DT denotes a
T9449 1371-1386 JJ denotes HOIP-containing
T9450 1387-1394 NN denotes complex
T9451 1395-1398 MD denotes can
T9452 1399-1407 VB denotes interact
T9453 1408-1412 IN denotes with
T9454 1413-1417 NNP denotes IKKγ
T9455 1418-1421 CC denotes and
T9456 1422-1432 VB denotes facilitate
T9457 1433-1443 NN denotes activation
T9458 1444-1446 IN denotes of
T9459 1447-1452 NNP denotes NF-κB
T9460 1453-1456 IN denotes via
T9461 1457-1460 DT denotes the
T9462 1461-1470 JJ denotes canonical
T9463 1471-1478 NN denotes pathway
T9464 1479-1480 NNP denotes [
T9465 1480-1482 CD denotes 16
T9466 1482-1483 NNP denotes ]
T9467 1483-1484 . denotes .
T9468 1485-1490 DT denotes These
T9469 1491-1495 NNS denotes data
T9470 1495-1496 , denotes ,
T9471 1497-1507 VBN denotes considered
T9472 1508-1516 RB denotes together
T9473 1517-1521 IN denotes with
T9474 1522-1526 JJ denotes ours
T9475 1526-1527 , denotes ,
T9476 1528-1535 VBP denotes suggest
T9477 1536-1540 IN denotes that
T9478 1541-1542 DT denotes a
T9479 1543-1558 JJ denotes HOIP-containing
T9480 1559-1566 JJ denotes complex
T9481 1567-1575 NNS denotes mediates
T9482 1576-1587 NN denotes recruitment
T9483 1588-1590 IN denotes of
T9484 1591-1595 NNP denotes IKKγ
T9485 1596-1598 TO denotes to
T9486 1599-1602 DT denotes the
T9487 1603-1607 NNP denotes CD40
T9488 1608-1617 VBG denotes signaling
T9489 1618-1625 NN denotes complex
T9490 1625-1626 . denotes .
T9491 1627-1629 IN denotes In
T9492 1630-1638 NN denotes addition
T9493 1638-1639 , denotes ,
T9494 1640-1655 JJ denotes CD40-associated
T9495 1656-1660 NNP denotes HOIP
T9496 1661-1666 MD denotes could
T9497 1667-1671 VB denotes play
T9498 1672-1673 DT denotes a
T9499 1674-1678 NN denotes role
T9500 1679-1681 IN denotes in
T9501 1682-1692 VBG denotes activating
T9502 1693-1697 NNP denotes IKKγ
T9503 1698-1703 IN denotes after
T9504 1704-1707 PRP$ denotes its
T9505 1708-1719 NN denotes recruitment
T9506 1720-1722 TO denotes to
T9507 1723-1726 DT denotes the
T9508 1727-1736 VBG denotes signaling
T9509 1737-1744 JJ denotes complex
T9510 1745-1746 NNP denotes [
T9511 1746-1748 CD denotes 16
T9512 1748-1749 NNP denotes ]
T9513 1749-1750 . denotes .
T9514 1751-1754 DT denotes The
T9515 1755-1761 JJR denotes higher
T9516 1762-1771 JJ denotes molecular
T9517 1772-1778 NN denotes weight
T9518 1779-1784 NNS denotes forms
T9519 1785-1787 IN denotes of
T9520 1788-1792 NNP denotes IKKγ
T9521 1793-1795 PRP denotes we
T9522 1796-1804 VBD denotes observed
T9523 1805-1807 IN denotes in
T9524 1808-1812 CD denotes CD40
T9525 1813-1831 NNS denotes immunoprecipitates
T9526 1832-1837 MD denotes would
T9527 1838-1840 VB denotes be
T9528 1841-1851 JJ denotes consistent
T9529 1852-1856 IN denotes with
T9530 1857-1860 DT denotes the
T9531 1861-1869 NN denotes presence
T9532 1870-1872 IN denotes of
T9533 1873-1893 JJ denotes post-transcriptional
T9534 1894-1907 NNS denotes modifications
T9535 1908-1917 VBG denotes including
T9536 1918-1933 NN denotes phosphorylation
T9537 1934-1937 CC denotes and
T9538 1938-1952 NN denotes ubiquitination
T9539 1952-1953 , denotes ,
T9540 1954-1959 WDT denotes which
T9541 1960-1964 VBP denotes have
T9542 1965-1969 VBN denotes been
T9543 1970-1979 VBN denotes suggested
T9544 1980-1982 TO denotes to
T9545 1983-1989 VB denotes reduce
T9546 1990-1992 CC denotes or
T9547 1993-2000 VB denotes enhance
T9548 2001-2005 JJ denotes IKKγ
T9549 2006-2014 NN denotes activity
T9550 2014-2015 , denotes ,
T9551 2016-2028 RB denotes respectively
T9552 2029-2030 NNP denotes [
T9553 2030-2032 CD denotes 16
T9554 2032-2033 NNP denotes ]
T9555 2033-2034 , denotes ,
T9556 2035-2036 NNP denotes [
T9557 2036-2038 CD denotes 17
T9558 2038-2039 NNP denotes ]
T9559 2039-2040 . denotes .
T9560 2041-2044 DT denotes The
T9561 2045-2055 NNS denotes mechanisms
T9562 2056-2058 IN denotes by
T9563 2059-2064 WDT denotes which
T9564 2065-2069 NNP denotes HOIP
T9565 2070-2078 VBZ denotes mediates
T9566 2079-2090 NN denotes recruitment
T9567 2091-2093 IN denotes of
T9568 2094-2097 DT denotes the
T9569 2098-2101 NNP denotes IKK
T9570 2102-2109 NN denotes complex
T9571 2110-2112 TO denotes to
T9572 2113-2117 NNP denotes CD40
T9573 2118-2121 CC denotes and
T9574 2122-2124 IN denotes by
T9575 2125-2130 WDT denotes which
T9576 2131-2135 NNP denotes HOIP
T9577 2136-2138 VBZ denotes is
T9578 2139-2148 VBN denotes recruited
T9579 2149-2151 TO denotes to
T9580 2152-2156 NNP denotes CD40
T9581 2157-2163 VBP denotes remain
T9582 2164-2171 JJ denotes unclear
T9583 2171-2172 . denotes .
T9584 2173-2174 DT denotes A
T9585 2175-2183 JJ denotes previous
T9586 2184-2189 NN denotes study
T9587 2190-2199 VBZ denotes indicates
T9588 2200-2204 IN denotes that
T9589 2205-2209 NNP denotes HOIP
T9590 2210-2213 MD denotes may
T9591 2214-2221 VB denotes mediate
T9592 2222-2228 JJ denotes direct
T9593 2229-2237 NNS denotes contacts
T9594 2238-2242 IN denotes with
T9595 2243-2246 DT denotes the
T9596 2247-2250 NNP denotes IKK
T9597 2251-2258 JJ denotes complex
T9598 2259-2260 NNP denotes [
T9599 2260-2262 CD denotes 16
T9600 2262-2263 NNP denotes ]
T9601 2263-2264 , denotes ,
T9602 2265-2275 VBG denotes suggesting
T9603 2276-2280 IN denotes that
T9604 2281-2283 PRP denotes it
T9605 2284-2293 NNS denotes functions
T9606 2294-2296 IN denotes as
T9607 2297-2299 DT denotes an
T9608 2300-2307 NN denotes adaptor
T9609 2308-2311 IN denotes for
T9610 2312-2315 DT denotes the
T9611 2316-2327 NN denotes recruitment
T9612 2328-2330 IN denotes of
T9613 2331-2334 DT denotes the
T9614 2335-2338 NNP denotes IKK
T9615 2339-2346 NN denotes complex
T9616 2347-2349 TO denotes to
T9617 2350-2354 NNP denotes CD40
T9618 2354-2355 . denotes .
T9619 2356-2363 RB denotes However
T9620 2363-2364 , denotes ,
T9621 2365-2368 DT denotes the
T9622 2369-2378 NN denotes ubiquitin
T9623 2379-2385 NN denotes ligase
T9624 2386-2394 NN denotes activity
T9625 2395-2397 IN denotes of
T9626 2398-2402 NNP denotes HOIP
T9627 2403-2411 VBZ denotes suggests
T9628 2412-2416 IN denotes that
T9629 2417-2419 PRP denotes it
T9630 2420-2422 VBZ denotes is
T9631 2423-2427 JJR denotes more
T9632 2428-2432 IN denotes than
T9633 2433-2434 DT denotes a
T9634 2435-2441 JJ denotes simple
T9635 2442-2449 NN denotes adapter
T9636 2450-2458 NN denotes molecule
T9637 2458-2459 . denotes .
T9638 2460-2462 IN denotes As
T9639 2463-2467 NNP denotes IKKγ
T9640 2468-2475 VBZ denotes appears
T9641 2476-2483 JJ denotes capable
T9642 2484-2486 IN denotes of
T9643 2487-2494 JJ denotes binding
T9644 2495-2501 JJ denotes linear
T9645 2502-2515 NN denotes polyubiquitin
T9646 2516-2517 NNP denotes [
T9647 2517-2519 CD denotes 18
T9648 2519-2520 NNP denotes ]
T9649 2520-2521 , denotes ,
T9650 2522-2523 NNP denotes [
T9651 2523-2525 CD denotes 19
T9652 2525-2526 NNP denotes ]
T9653 2526-2527 , denotes ,
T9654 2528-2530 PRP denotes it
T9655 2531-2533 VBZ denotes is
T9656 2534-2542 JJ denotes possible
T9657 2543-2547 IN denotes that
T9658 2548-2552 NNP denotes HOIP
T9659 2553-2560 VBZ denotes directs
T9660 2561-2570 NN denotes formation
T9661 2571-2573 IN denotes of
T9662 2574-2580 JJ denotes linear
T9663 2581-2594 NN denotes polyubiquitin
T9664 2595-2601 NNS denotes chains
T9665 2602-2604 IN denotes on
T9666 2605-2606 DT denotes a
T9667 2607-2622 JJ denotes CD40-associated
T9668 2623-2629 NN denotes factor
T9669 2629-2630 , denotes ,
T9670 2631-2634 CC denotes and
T9671 2635-2637 PRP denotes it
T9672 2638-2640 VBZ denotes is
T9673 2641-2646 DT denotes these
T9674 2647-2653 NNS denotes chains
T9675 2654-2658 WDT denotes that
T9676 2659-2664 VBP denotes serve
T9677 2665-2667 TO denotes to
T9678 2668-2675 VB denotes recruit
T9679 2676-2680 NNP denotes IKKγ
T9680 2681-2683 TO denotes to
T9681 2684-2687 DT denotes the
T9682 2688-2692 NNP denotes CD40
T9683 2693-2702 VBG denotes signaling
T9684 2703-2710 NN denotes complex
T9685 2710-2711 . denotes .
T9686 2712-2715 DT denotes The
T9687 2716-2725 JJ denotes molecular
T9688 2726-2738 NNS denotes interactions
T9689 2739-2748 JJ denotes necessary
T9690 2749-2752 IN denotes for
T9691 2753-2764 NN denotes recruitment
T9692 2765-2767 IN denotes of
T9693 2768-2772 NNP denotes HOIP
T9694 2773-2779 PRP denotes itself
T9695 2780-2782 TO denotes to
T9696 2783-2786 DT denotes the
T9697 2787-2791 NNP denotes CD40
T9698 2792-2801 VBG denotes signaling
T9699 2802-2809 NN denotes complex
T9700 2810-2814 RB denotes also
T9701 2815-2821 VBP denotes remain
T9702 2822-2824 TO denotes to
T9703 2825-2827 VB denotes be
T9704 2828-2833 RB denotes fully
T9705 2834-2847 VBN denotes characterized
T9706 2847-2848 . denotes .
T9707 2849-2851 PRP denotes We
T9708 2852-2862 RB denotes previously
T9709 2863-2869 VBD denotes showed
T9710 2870-2874 IN denotes that
T9711 2875-2878 DT denotes the
T9712 2879-2890 NN denotes recruitment
T9713 2891-2893 IN denotes of
T9714 2894-2898 NNP denotes HOIP
T9715 2899-2901 TO denotes to
T9716 2902-2905 DT denotes the
T9717 2906-2915 VBG denotes signaling
T9718 2916-2923 NN denotes complex
T9719 2924-2926 VBZ denotes is
T9720 2927-2942 JJ denotes TRAF2-dependent
T9721 2943-2944 NN denotes [
T9722 2944-2945 CD denotes 8
T9723 2945-2946 NNP denotes ]
T9724 2946-2947 . denotes .
T9725 2948-2959 RB denotes Potentially
T9726 2959-2960 , denotes ,
T9727 2961-2966 CD denotes TRAF2
T9728 2967-2970 CC denotes and
T9729 2971-2975 NNP denotes HOIP
T9730 2976-2984 RB denotes directly
T9731 2985-2993 VBP denotes interact
T9732 2993-2994 , denotes ,
T9733 2995-2998 CC denotes but
T9734 2999-3001 PRP denotes it
T9735 3002-3004 VBZ denotes is
T9736 3005-3013 JJ denotes possible
T9737 3014-3018 IN denotes that
T9738 3019-3022 DT denotes the
T9739 3023-3032 NN denotes ubiquitin
T9740 3033-3039 NN denotes ligase
T9741 3040-3048 NN denotes activity
T9742 3049-3051 IN denotes of
T9743 3052-3057 CD denotes TRAF2
T9744 3058-3059 NNP denotes [
T9745 3059-3061 CD denotes 20
T9746 3061-3062 NNP denotes ]
T9747 3063-3064 -LRB- denotes (
T9748 3064-3066 CC denotes or
T9749 3067-3083 JJ denotes TRAF2-associated
T9750 3084-3092 NNS denotes proteins
T9751 3092-3093 , denotes ,
T9752 3094-3098 JJ denotes such
T9753 3099-3101 IN denotes as
T9754 3102-3105 DT denotes the
T9755 3106-3111 NNP denotes cIAPs
T9756 3112-3113 NNP denotes [
T9757 3113-3115 CD denotes 21
T9758 3115-3116 NNP denotes ]
T9759 3116-3117 -RRB- denotes )
T9760 3118-3127 VBZ denotes generates
T9761 3128-3138 JJ denotes K63-linked
T9762 3139-3152 NN denotes polyubiquitin
T9763 3153-3159 NNS denotes chains
T9764 3160-3162 TO denotes to
T9765 3163-3168 WDT denotes which
T9766 3169-3173 NNP denotes HOIP
T9767 3174-3177 MD denotes can
T9768 3178-3182 NN denotes bind
T9769 3183-3186 CC denotes and
T9770 3187-3191 RB denotes thus
T9771 3192-3201 JJ denotes associate
T9772 3202-3206 IN denotes with
T9773 3207-3210 DT denotes the
T9774 3211-3215 NNP denotes CD40
T9775 3216-3225 VBG denotes signaling
T9776 3226-3233 JJ denotes complex
T9777 3234-3235 NNP denotes [
T9778 3235-3237 CD denotes 22
T9779 3237-3238 NNP denotes ]
T9780 3238-3239 . denotes .
T9781 3240-3245 IN denotes While
T9782 3246-3249 PRP$ denotes our
T9783 3250-3258 JJ denotes previous
T9784 3259-3263 NN denotes work
T9785 3264-3273 VBD denotes indicated
T9786 3274-3275 DT denotes a
T9787 3276-3287 RB denotes potentially
T9788 3288-3297 JJ denotes important
T9789 3298-3302 NN denotes link
T9790 3303-3310 IN denotes between
T9791 3311-3316 CD denotes TRAF2
T9792 3317-3320 CC denotes and
T9793 3321-3325 NNP denotes HOIP
T9794 3326-3328 IN denotes in
T9795 3329-3333 NNP denotes CD40
T9796 3334-3343 VBG denotes signaling
T9797 3343-3344 , denotes ,
T9798 3345-3348 DT denotes the
T9799 3349-3356 NNS denotes signals
T9800 3357-3360 CC denotes and
T9801 3361-3370 NNS denotes functions
T9802 3371-3377 VBN denotes tested
T9803 3378-3382 RB denotes here
T9804 3383-3386 VBP denotes are
T9805 3387-3396 JJ denotes dependent
T9806 3397-3401 IN denotes upon
T9807 3402-3407 CD denotes TRAF6
T9808 3408-3410 RB denotes as
T9809 3411-3415 RB denotes well
T9810 3416-3418 IN denotes as
T9811 3419-3424 CD denotes TRAF2
T9812 3424-3425 . denotes .
T9813 3426-3428 IN denotes In
T9814 3429-3437 JJ denotes previous
T9815 3438-3449 NNS denotes experiments
T9816 3450-3454 IN denotes with
T9817 3455-3469 JJ denotes TRAF-deficient
T9818 3470-3473 NNP denotes A20
T9819 3473-3475 CD denotes .2
T9820 3475-3476 NNP denotes J
T9821 3477-3482 NNS denotes cells
T9822 3482-3483 , denotes ,
T9823 3484-3486 PRP denotes we
T9824 3487-3492 VBD denotes found
T9825 3493-3497 IN denotes that
T9826 3498-3501 DT denotes the
T9827 3502-3512 NN denotes activation
T9828 3513-3515 IN denotes of
T9829 3516-3521 NN denotes NF-κB
T9830 3522-3524 IN denotes by
T9831 3525-3529 NNP denotes CD40
T9832 3530-3535 MD denotes could
T9833 3536-3538 VB denotes be
T9834 3539-3547 VBN denotes mediated
T9835 3548-3550 IN denotes by
T9836 3551-3557 DT denotes either
T9837 3558-3563 CD denotes TRAF2
T9838 3564-3566 CC denotes or
T9839 3567-3572 CD denotes TRAF6
T9840 3572-3573 , denotes ,
T9841 3574-3579 IN denotes while
T9842 3580-3590 NN denotes activation
T9843 3591-3593 IN denotes of
T9844 3594-3597 NNP denotes JNK
T9845 3598-3600 IN denotes by
T9846 3601-3605 NNP denotes CD40
T9847 3606-3609 VBD denotes was
T9848 3610-3617 RB denotes largely
T9849 3618-3627 JJ denotes dependent
T9850 3628-3630 IN denotes on
T9851 3631-3636 CD denotes TRAF6
T9852 3637-3642 RB denotes alone
T9853 3643-3644 JJ denotes [
T9854 3644-3645 CD denotes 8
T9855 3645-3646 NN denotes ]
T9856 3646-3647 . denotes .
T9857 3648-3652 NNP denotes HOIP
T9858 3653-3663 NN denotes deficiency
T9859 3664-3675 VBZ denotes compromises
T9860 3676-3679 DT denotes the
T9861 3680-3693 JJ denotes CD40-mediated
T9862 3694-3704 NN denotes activation
T9863 3705-3707 IN denotes of
T9864 3708-3712 DT denotes both
T9865 3713-3718 NNP denotes NF-κB
T9866 3719-3722 CC denotes and
T9867 3723-3726 NNP denotes JNK
T9868 3726-3727 , denotes ,
T9869 3728-3738 VBG denotes indicating
T9870 3739-3743 IN denotes that
T9871 3744-3751 NNS denotes signals
T9872 3752-3760 VBN denotes mediated
T9873 3761-3763 IN denotes by
T9874 3764-3768 DT denotes both
T9875 3769-3774 CD denotes TRAF2
T9876 3775-3778 CC denotes and
T9877 3779-3784 CD denotes TRAF6
T9878 3785-3791 JJ denotes likely
T9879 3792-3796 NN denotes pass
T9880 3797-3804 IN denotes through
T9881 3805-3809 NNP denotes HOIP
T9882 3809-3810 . denotes .
T9883 3811-3814 PRP$ denotes Our
T9884 3815-3823 JJ denotes previous
T9885 3824-3828 NN denotes work
T9886 3829-3833 RB denotes also
T9887 3834-3846 VBD denotes demonstrated
T9888 3847-3851 IN denotes that
T9889 3852-3855 DT denotes the
T9890 3856-3869 JJ denotes CD40-mediated
T9891 3870-3880 NN denotes activation
T9892 3881-3883 IN denotes of
T9893 3884-3889 NNP denotes NF-κB
T9894 3890-3893 CC denotes and
T9895 3894-3897 NNP denotes JNK
T9896 3897-3898 , denotes ,
T9897 3899-3904 IN denotes while
T9898 3905-3920 JJ denotes TRAF6-dependent
T9899 3920-3921 , denotes ,
T9900 3922-3925 VBD denotes was
T9901 3926-3929 RB denotes not
T9902 3930-3941 VBN denotes compromised
T9903 3942-3944 IN denotes by
T9904 3945-3948 DT denotes the
T9905 3949-3959 NN denotes disruption
T9906 3960-3962 IN denotes of
T9907 3963-3966 DT denotes the
T9908 3967-3974 JJ denotes binding
T9909 3975-3979 NN denotes site
T9910 3980-3983 IN denotes for
T9911 3984-3989 CD denotes TRAF6
T9912 3990-3992 IN denotes in
T9913 3993-3996 DT denotes the
T9914 3997-4008 JJ denotes cytoplasmic
T9915 4009-4015 NN denotes domain
T9916 4016-4018 IN denotes of
T9917 4019-4023 CD denotes CD40
T9918 4024-4026 CC denotes or
T9919 4027-4035 NN denotes deletion
T9920 4036-4038 IN denotes of
T9921 4039-4042 DT denotes the
T9922 4043-4051 NN denotes receptor
T9923 4052-4059 JJ denotes binding
T9924 4060-4066 NN denotes domain
T9925 4067-4068 -LRB- denotes (
T9926 4068-4071 DT denotes the
T9927 4072-4078 NNP denotes TRAF-C
T9928 4079-4085 NN denotes domain
T9929 4085-4086 -RRB- denotes )
T9930 4087-4089 IN denotes in
T9931 4090-4095 CD denotes TRAF6
T9932 4096-4097 NN denotes [
T9933 4097-4098 CD denotes 8
T9934 4098-4099 NNP denotes ]
T9935 4099-4100 . denotes .
T9936 4101-4106 DT denotes These
T9937 4107-4119 NNS denotes observations
T9938 4120-4128 VBP denotes indicate
T9939 4129-4133 IN denotes that
T9940 4134-4139 CD denotes TRAF6
T9941 4140-4144 MD denotes need
T9942 4145-4148 RB denotes not
T9943 4149-4157 RB denotes directly
T9944 4158-4162 NN denotes bind
T9945 4163-4167 CD denotes CD40
T9946 4168-4170 IN denotes in
T9947 4171-4176 NN denotes order
T9948 4177-4179 TO denotes to
T9949 4180-4187 VB denotes mediate
T9950 4188-4195 JJ denotes certain
T9951 4196-4203 NNS denotes signals
T9952 4203-4204 , denotes ,
T9953 4205-4215 VBG denotes suggesting
T9954 4216-4219 DT denotes the
T9955 4220-4228 NN denotes assembly
T9956 4229-4231 IN denotes of
T9957 4232-4233 DT denotes a
T9958 4234-4243 VBG denotes signaling
T9959 4244-4251 NN denotes complex
T9960 4252-4255 RB denotes not
T9961 4256-4264 RB denotes directly
T9962 4265-4275 VBN denotes associated
T9963 4276-4280 IN denotes with
T9964 4281-4284 DT denotes the
T9965 4285-4293 NN denotes receptor
T9966 4293-4294 . denotes .
T9967 4295-4297 IN denotes If
T9968 4298-4302 PDT denotes such
T9969 4303-4304 DT denotes a
T9970 4305-4312 JJ denotes complex
T9971 4313-4319 VBZ denotes exists
T9972 4319-4320 , denotes ,
T9973 4321-4324 PRP$ denotes our
T9974 4325-4332 NNS denotes results
T9975 4333-4341 VBP denotes indicate
T9976 4342-4346 IN denotes that
T9977 4347-4350 DT denotes the
T9978 4351-4358 NN denotes absence
T9979 4359-4361 IN denotes of
T9980 4362-4366 NNP denotes HOIP
T9981 4367-4378 VBZ denotes compromises
T9982 4379-4382 PRP$ denotes its
T9983 4383-4391 NN denotes function
T9984 4392-4394 RB denotes as
T9985 4395-4399 RB denotes well
T9986 4399-4400 . denotes .
T9987 4401-4409 IN denotes Although
T9988 4410-4413 DT denotes the
T9989 4414-4425 NNS denotes experiments
T9990 4426-4435 VBN denotes presented
T9991 4436-4440 RB denotes here
T9992 4441-4446 VB denotes focus
T9993 4447-4449 IN denotes on
T9994 4450-4454 NNP denotes CD40
T9995 4454-4455 , denotes ,
T9996 4456-4459 PRP$ denotes our
T9997 4460-4467 NNS denotes results
T9998 4468-4471 CC denotes and
T9999 4472-4477 DT denotes those
T10000 4478-4480 IN denotes of
T10001 4481-4486 JJ denotes other
T10002 4487-4493 NNS denotes groups
T10003 4494-4495 NNP denotes [
T10004 4495-4497 CD denotes 16
T10005 4497-4498 NNP denotes ]
T10006 4498-4499 , denotes ,
T10007 4500-4501 NNP denotes [
T10008 4501-4503 CD denotes 22
T10009 4503-4504 JJ denotes ]
T10010 4505-4512 NN denotes support
T10011 4513-4516 DT denotes the
T10012 4517-4528 NN denotes possibility
T10013 4529-4533 WDT denotes that
T10014 4534-4538 NNP denotes HOIP
T10015 4539-4541 VBZ denotes is
T10016 4542-4551 JJ denotes important
T10017 4552-4554 IN denotes in
T10018 4555-4559 JJ denotes many
T10019 4560-4569 VBG denotes signaling
T10020 4570-4578 NNS denotes pathways
T10021 4579-4581 IN denotes in
T10022 4582-4587 WDT denotes which
T10023 4588-4593 CD denotes TRAF2
T10024 4594-4596 CC denotes or
T10025 4597-4602 CD denotes TRAF6
T10026 4603-4606 VBP denotes are
T10027 4607-4615 VBN denotes involved
T10028 4615-4616 , denotes ,
T10029 4617-4626 VBG denotes including
T10030 4627-4632 DT denotes those
T10031 4633-4643 VBN denotes associated
T10032 4644-4648 IN denotes with
T10033 4649-4656 JJ denotes various
T10034 4657-4664 NNS denotes members
T10035 4665-4667 IN denotes of
T10036 4668-4671 DT denotes the
T10037 4672-4675 NNP denotes TNF
T10038 4676-4684 NN denotes receptor
T10039 4685-4696 RB denotes superfamily
T10040 4697-4700 CC denotes and
T10041 4701-4704 DT denotes the
T10042 4705-4714 JJ denotes Toll-like
T10043 4715-4724 NNS denotes receptors
T10044 4724-4725 . denotes .
T10045 4726-4729 DT denotes The
T10046 4730-4739 JJ denotes potential
T10047 4740-4750 NN denotes importance
T10048 4751-4753 IN denotes of
T10049 4754-4758 NNP denotes HOIP
T10050 4759-4761 IN denotes in
T10051 4762-4768 JJ denotes immune
T10052 4769-4777 NN denotes function
T10053 4778-4781 CC denotes and
T10054 4782-4786 NNP denotes TNFR
T10055 4787-4793 NN denotes family
T10056 4794-4803 VBG denotes signaling
T10057 4804-4806 VBZ denotes is
T10058 4807-4814 JJ denotes further
T10059 4815-4824 VBN denotes supported
T10060 4825-4827 IN denotes by
T10061 4828-4831 DT denotes the
T10062 4832-4838 JJ denotes recent
T10063 4839-4848 NN denotes discovery
T10064 4849-4853 WDT denotes that
T10065 4854-4858 NNP denotes HOIP
T10066 4859-4868 VBZ denotes interacts
T10067 4869-4873 IN denotes with
T10068 4874-4875 DT denotes a
T10069 4876-4883 NN denotes protein
T10070 4884-4889 VBN denotes known
T10071 4890-4892 IN denotes as
T10072 4893-4900 NNP denotes SHARPIN
T10073 4901-4902 -LRB- denotes (
T10074 4902-4918 JJ denotes SHANK-associated
T10075 4919-4921 NNP denotes RH
T10076 4922-4928 NN denotes domain
T10077 4929-4940 VBG denotes interacting
T10078 4941-4948 NN denotes protein
T10079 4949-4951 IN denotes in
T10080 4952-4964 JJ denotes postsynaptic
T10081 4965-4972 NN denotes density
T10082 4972-4973 -RRB- denotes )
T10083 4973-4974 , denotes ,
T10084 4975-4980 WDT denotes which
T10085 4981-4988 VBZ denotes appears
T10086 4989-4996 JJ denotes capable
T10087 4997-4999 IN denotes of
T10088 5000-5007 VBG denotes working
T10089 5008-5016 RB denotes together
T10090 5017-5021 IN denotes with
T10091 5022-5026 NNP denotes HOIP
T10092 5027-5030 CC denotes and
T10093 5031-5035 NNP denotes HOIL
T10094 5036-5038 TO denotes to
T10095 5039-5046 VB denotes mediate
T10096 5047-5050 DT denotes the
T10097 5051-5059 NN denotes assembly
T10098 5060-5062 IN denotes of
T10099 5063-5069 JJ denotes linear
T10100 5070-5083 NN denotes polyubiquitin
T10101 5084-5085 NNP denotes [
T10102 5085-5087 CD denotes 14
T10103 5087-5088 NNP denotes ]
T10104 5088-5089 , denotes ,
T10105 5090-5091 NNP denotes [
T10106 5091-5093 CD denotes 23
T10107 5093-5094 NNP denotes ]
T10108 5094-5095 , denotes ,
T10109 5096-5097 NNP denotes [
T10110 5097-5099 CD denotes 24
T10111 5099-5100 NNP denotes ]
T10112 5100-5101 . denotes .
T10113 5102-5115 RB denotes Interestingly
T10114 5115-5116 , denotes ,
T10115 5117-5121 NNS denotes mice
T10116 5122-5126 IN denotes with
T10117 5127-5128 DT denotes a
T10118 5129-5140 JJ denotes spontaneous
T10119 5141-5149 NN denotes mutation
T10120 5150-5152 IN denotes in
T10121 5153-5156 DT denotes the
T10122 5157-5161 NN denotes gene
T10123 5162-5170 VBG denotes encoding
T10124 5171-5178 NNP denotes SHARPIN
T10125 5179-5180 -LRB- denotes (
T10126 5180-5187 JJ denotes chronic
T10127 5188-5201 JJ denotes proliferative
T10128 5202-5212 NNS denotes dermatitis
T10129 5213-5214 -LRB- denotes (
T10130 5214-5218 NN denotes cpdm
T10131 5218-5219 -RRB- denotes )
T10132 5220-5224 NNS denotes mice
T10133 5224-5225 -RRB- denotes )
T10134 5226-5233 VBP denotes exhibit
T10135 5234-5241 JJ denotes chronic
T10136 5242-5254 NN denotes inflammation
T10137 5255-5257 IN denotes of
T10138 5258-5261 DT denotes the
T10139 5262-5266 NN denotes skin
T10140 5267-5270 CC denotes and
T10141 5271-5279 JJ denotes internal
T10142 5280-5286 NNS denotes organs
T10143 5286-5287 , denotes ,
T10144 5288-5297 JJ denotes defective
T10145 5298-5309 NN denotes development
T10146 5310-5312 IN denotes of
T10147 5313-5322 JJ denotes secondary
T10148 5323-5331 JJ denotes lymphoid
T10149 5332-5338 NN denotes tissue
T10150 5338-5339 , denotes ,
T10151 5340-5343 CC denotes and
T10152 5344-5351 NNS denotes defects
T10153 5352-5354 IN denotes in
T10154 5355-5358 DT denotes the
T10155 5359-5369 NN denotes production
T10156 5370-5372 IN denotes of
T10157 5373-5381 VBN denotes switched
T10158 5382-5396 NN denotes immunoglobulin
T10159 5397-5405 NNS denotes isotypes
T10160 5406-5407 NNP denotes [
T10161 5407-5409 CD denotes 17
T10162 5409-5410 NNP denotes ]
T10163 5410-5411 , denotes ,
T10164 5412-5413 NNP denotes [
T10165 5413-5415 CD denotes 25
T10166 5415-5416 NNP denotes ]
T10167 5416-5417 . denotes .
T10168 5418-5421 DT denotes The
T10169 5422-5432 RB denotes apparently
T10170 5433-5441 JJ denotes intimate
T10171 5442-5452 JJ denotes functional
T10172 5453-5457 NN denotes link
T10173 5458-5465 IN denotes between
T10174 5466-5473 NNP denotes SHARPIN
T10175 5474-5477 CC denotes and
T10176 5478-5482 NNP denotes HOIP
T10177 5483-5491 RB denotes strongly
T10178 5492-5500 VBZ denotes suggests
T10179 5501-5505 IN denotes that
T10180 5506-5508 IN denotes at
T10181 5509-5514 JJS denotes least
T10182 5515-5519 NN denotes part
T10183 5520-5522 IN denotes of
T10184 5523-5526 DT denotes the
T10185 5527-5531 NN denotes cpdm
T10186 5532-5541 NN denotes phenotype
T10187 5542-5547 VBZ denotes stems
T10188 5548-5552 IN denotes from
T10189 5553-5560 NNS denotes defects
T10190 5561-5563 IN denotes in
T10191 5564-5567 DT denotes the
T10192 5568-5578 NN denotes regulation
T10193 5579-5581 CC denotes or
T10194 5582-5590 NN denotes function
T10195 5591-5593 IN denotes of
T10196 5594-5598 NNP denotes HOIP
T10197 5598-5599 . denotes .
R7034 T9222 T9223 poss Our,results
R7035 T9223 T9224 nsubj results,indicate
R7036 T9224 T9224 ROOT indicate,indicate
R7037 T9225 T9229 mark that,is
R7038 T9226 T9227 det the,protein
R7039 T9227 T9229 nsubj protein,is
R7040 T9228 T9229 nsubj HOIP,is
R7041 T9229 T9224 ccomp is,indicate
R7042 T9230 T9229 acomp critical,is
R7043 T9231 T9230 prep for,critical
R7044 T9232 T9233 amod CD40-induced,signals
R7045 T9233 T9231 pobj signals,for
R7046 T9234 T9235 nsubj that,regulate
R7047 T9235 T9233 relcl regulate,signals
R7048 T9236 T9238 compound B,function
R7049 T9237 T9238 compound cell,function
R7050 T9238 T9235 dobj function,regulate
R7051 T9239 T9224 punct .,indicate
R7052 T9240 T9241 poss Our,data
R7053 T9241 T9242 nsubj data,show
R7054 T9242 T9242 ROOT show,show
R7055 T9243 T9247 mark that,include
R7056 T9244 T9246 amod HOIP-dependent,responses
R7057 T9245 T9246 amod cellular,responses
R7058 T9246 T9247 nsubj responses,include
R7059 T9247 T9242 ccomp include,show
R7060 T9248 T9249 amod CD40-mediated,upregulation
R7061 T9249 T9247 dobj upregulation,include
R7062 T9250 T9249 prep of,upregulation
R7063 T9251 T9252 nummod CD80,expression
R7064 T9252 T9250 pobj expression,of
R7065 T9253 T9252 cc and,expression
R7066 T9254 T9252 conj synthesis,expression
R7067 T9255 T9252 prep of,expression
R7068 T9256 T9258 compound germline,transcripts
R7069 T9257 T9258 compound RNA,transcripts
R7070 T9258 T9255 pobj transcripts,of
R7071 T9259 T9258 prep from,transcripts
R7072 T9260 T9264 det the,locus
R7073 T9261 T9264 amod immunoglobulin,locus
R7074 T9262 T9264 amod heavy,locus
R7075 T9263 T9264 compound chain,locus
R7076 T9264 T9259 pobj locus,from
R7077 T9265 T9264 punct ",",locus
R7078 T9266 T9267 nummod two,events
R7079 T9267 T9264 appos events,locus
R7080 T9268 T9269 nsubj that,are
R7081 T9269 T9267 relcl are,events
R7082 T9270 T9269 acomp important,are
R7083 T9271 T9270 prep for,important
R7084 T9272 T9275 amod T-cell-dependent,responses
R7085 T9273 T9275 amod antibody-mediated,responses
R7086 T9274 T9275 amod immune,responses
R7087 T9275 T9271 pobj responses,for
R7088 T9276 T9242 punct .,show
R7089 T9277 T9284 prep At,indicate
R7090 T9278 T9280 det the,level
R7091 T9279 T9280 amod molecular,level
R7092 T9280 T9277 pobj level,At
R7093 T9281 T9284 punct ",",indicate
R7094 T9282 T9283 poss our,data
R7095 T9283 T9284 nsubj data,indicate
R7096 T9284 T9284 ROOT indicate,indicate
R7097 T9285 T9287 mark that,functions
R7098 T9286 T9287 compound HOIP,functions
R7099 T9287 T9284 ccomp functions,indicate
R7100 T9288 T9287 dobj downstream,functions
R7101 T9289 T9288 prep of,downstream
R7102 T9290 T9289 pobj TRAF2,of
R7103 T9291 T9288 prep in,downstream
R7104 T9292 T9295 det the,pathway
R7105 T9293 T9295 nmod CD40,pathway
R7106 T9294 T9295 amod signaling,pathway
R7107 T9295 T9291 pobj pathway,in
R7108 T9296 T9287 cc and,functions
R7109 T9297 T9299 mark that,has
R7110 T9298 T9299 nsubj HOIP,has
R7111 T9299 T9287 conj has,functions
R7112 T9300 T9302 det a,role
R7113 T9301 T9302 amod key,role
R7114 T9302 T9299 dobj role,has
R7115 T9303 T9302 prep in,role
R7116 T9304 T9303 pcomp promoting,in
R7117 T9305 T9306 det the,recruitment
R7118 T9306 T9304 dobj recruitment,promoting
R7119 T9307 T9306 prep of,recruitment
R7120 T9308 T9310 det the,complex
R7121 T9309 T9310 compound IKK,complex
R7122 T9310 T9307 pobj complex,of
R7123 T9311 T9310 prep to,complex
R7124 T9312 T9311 pobj CD40,to
R7125 T9313 T9284 punct .,indicate
R7126 T9314 T9319 advmod Consistent,activation
R7127 T9315 T9314 prep with,Consistent
R7128 T9316 T9315 pobj this,with
R7129 T9317 T9319 punct ",",activation
R7130 T9318 T9319 amod CD40-induced,activation
R7131 T9319 T9322 nsubj activation,is
R7132 T9320 T9319 prep of,activation
R7133 T9321 T9320 pobj NF-κB,of
R7134 T9322 T9322 ROOT is,is
R7135 T9323 T9322 acomp dependent,is
R7136 T9324 T9323 prep on,dependent
R7137 T9325 T9326 det the,presence
R7138 T9326 T9324 pobj presence,on
R7139 T9327 T9326 prep of,presence
R7140 T9328 T9327 pobj HOIP,of
R7141 T9329 T9322 punct .,is
R7142 T9330 T9335 prep In,show
R7143 T9331 T9330 pobj addition,In
R7144 T9332 T9335 punct ",",show
R7145 T9333 T9334 poss our,data
R7146 T9334 T9335 nsubj data,show
R7147 T9335 T9335 ROOT show,show
R7148 T9336 T9338 mark that,facilitates
R7149 T9337 T9338 nsubj HOIP,facilitates
R7150 T9338 T9335 ccomp facilitates,show
R7151 T9339 T9340 det the,activation
R7152 T9340 T9338 dobj activation,facilitates
R7153 T9341 T9340 prep of,activation
R7154 T9342 T9341 pobj JNK,of
R7155 T9343 T9338 prep in,facilitates
R7156 T9344 T9343 pobj response,in
R7157 T9345 T9344 prep to,response
R7158 T9346 T9347 amod CD40,engagement
R7159 T9347 T9345 pobj engagement,to
R7160 T9348 T9335 punct .,show
R7161 T9349 T9353 advmod Together,provide
R7162 T9350 T9353 punct ",",provide
R7163 T9351 T9352 poss our,findings
R7164 T9352 T9353 nsubj findings,provide
R7165 T9353 T9353 ROOT provide,provide
R7166 T9354 T9353 dobj support,provide
R7167 T9355 T9354 prep for,support
R7168 T9356 T9357 det the,conclusion
R7169 T9357 T9355 pobj conclusion,for
R7170 T9358 T9360 mark that,is
R7171 T9359 T9360 nsubj HOIP,is
R7172 T9360 T9357 acl is,conclusion
R7173 T9361 T9363 det a,component
R7174 T9362 T9363 amod key,component
R7175 T9363 T9360 attr component,is
R7176 T9364 T9363 prep of,component
R7177 T9365 T9368 det the,pathway
R7178 T9366 T9368 nmod CD40,pathway
R7179 T9367 T9368 amod signaling,pathway
R7180 T9368 T9364 pobj pathway,of
R7181 T9369 T9353 punct .,provide
R7182 T9370 T9386 prep Given,indicate
R7183 T9371 T9372 det the,importance
R7184 T9372 T9370 pobj importance,Given
R7185 T9373 T9372 prep of,importance
R7186 T9374 T9373 pobj CD40,of
R7187 T9375 T9370 pcomp signaling,Given
R7188 T9376 T9375 prep in,signaling
R7189 T9377 T9378 preconj both,cellular
R7190 T9378 T9382 amod cellular,responses
R7191 T9379 T9378 cc and,cellular
R7192 T9380 T9378 conj humoral,cellular
R7193 T9381 T9382 amod immune,responses
R7194 T9382 T9376 pobj responses,in
R7195 T9383 T9386 punct ",",indicate
R7196 T9384 T9385 poss our,results
R7197 T9385 T9386 nsubj results,indicate
R7198 T9386 T9386 ROOT indicate,indicate
R7199 T9387 T9389 mark that,has
R7200 T9388 T9389 nsubj HOIP,has
R7201 T9389 T9386 ccomp has,indicate
R7202 T9390 T9392 det a,role
R7203 T9391 T9392 amod critical,role
R7204 T9392 T9389 dobj role,has
R7205 T9393 T9392 prep in,role
R7206 T9394 T9395 det the,regulation
R7207 T9395 T9393 pobj regulation,in
R7208 T9396 T9395 prep of,regulation
R7209 T9397 T9399 det the,system
R7210 T9398 T9399 amod immune,system
R7211 T9399 T9396 pobj system,of
R7212 T9400 T9386 punct .,indicate
R7213 T9401 T9403 det The,properties
R7214 T9402 T9403 amod functional,properties
R7215 T9403 T9410 nsubjpass properties,characterized
R7216 T9404 T9403 prep of,properties
R7217 T9405 T9404 pobj HOIP,of
R7218 T9406 T9410 aux have,characterized
R7219 T9407 T9410 advmod only,characterized
R7220 T9408 T9410 auxpass been,characterized
R7221 T9409 T9410 advmod partially,characterized
R7222 T9410 T9410 ROOT characterized,characterized
R7223 T9411 T9410 punct .,characterized
R7224 T9412 T9413 amod Initial,studies
R7225 T9413 T9414 nsubj studies,showed
R7226 T9414 T9414 ROOT showed,showed
R7227 T9415 T9422 mark that,are
R7228 T9416 T9422 nsubj HOIP,are
R7229 T9417 T9416 cc and,HOIP
R7230 T9418 T9420 det the,protein
R7231 T9419 T9420 amod related,protein
R7232 T9420 T9416 conj protein,HOIP
R7233 T9421 T9416 conj HOIL-1,HOIP
R7234 T9422 T9414 ccomp are,showed
R7235 T9423 T9422 attr components,are
R7236 T9424 T9423 prep of,components
R7237 T9425 T9430 det a,kDa
R7238 T9426 T9430 amod large,kDa
R7239 T9427 T9430 punct (,kDa
R7240 T9428 T9430 nmod ∼,kDa
R7241 T9429 T9430 nummod 600,kDa
R7242 T9430 T9424 pobj kDa,of
R7243 T9431 T9430 punct ),kDa
R7244 T9432 T9433 npadvmod protein,complex
R7245 T9433 T9434 amod complex,capable
R7246 T9434 T9423 amod capable,components
R7247 T9435 T9434 prep of,capable
R7248 T9436 T9435 pcomp synthesizing,of
R7249 T9437 T9439 amod linear,chains
R7250 T9438 T9439 compound polyubiquitin,chains
R7251 T9439 T9436 dobj chains,synthesizing
R7252 T9440 T9422 conj [,are
R7253 T9441 T9442 nummod 5,]
R7254 T9442 T9440 dobj ],[
R7255 T9443 T9414 punct .,showed
R7256 T9444 T9445 amod Subsequent,studies
R7257 T9445 T9446 nsubj studies,showed
R7258 T9446 T9446 ROOT showed,showed
R7259 T9447 T9452 mark that,interact
R7260 T9448 T9450 det a,complex
R7261 T9449 T9450 compound HOIP-containing,complex
R7262 T9450 T9452 nsubj complex,interact
R7263 T9451 T9452 aux can,interact
R7264 T9452 T9446 ccomp interact,showed
R7265 T9453 T9452 prep with,interact
R7266 T9454 T9453 pobj IKKγ,with
R7267 T9455 T9452 cc and,interact
R7268 T9456 T9452 conj facilitate,interact
R7269 T9457 T9456 dobj activation,facilitate
R7270 T9458 T9457 prep of,activation
R7271 T9459 T9458 pobj NF-κB,of
R7272 T9460 T9456 prep via,facilitate
R7273 T9461 T9463 det the,pathway
R7274 T9462 T9463 amod canonical,pathway
R7275 T9463 T9460 pobj pathway,via
R7276 T9464 T9466 nmod [,]
R7277 T9465 T9466 nummod 16,]
R7278 T9466 T9463 appos ],pathway
R7279 T9467 T9446 punct .,showed
R7280 T9468 T9469 det These,data
R7281 T9469 T9476 nsubj data,suggest
R7282 T9470 T9469 punct ",",data
R7283 T9471 T9469 acl considered,data
R7284 T9472 T9473 advmod together,with
R7285 T9473 T9471 prep with,considered
R7286 T9474 T9473 pobj ours,with
R7287 T9475 T9476 punct ",",suggest
R7288 T9476 T9476 ROOT suggest,suggest
R7289 T9477 T9476 dobj that,suggest
R7290 T9478 T9482 det a,recruitment
R7291 T9479 T9482 amod HOIP-containing,recruitment
R7292 T9480 T9481 amod complex,mediates
R7293 T9481 T9482 compound mediates,recruitment
R7294 T9482 T9477 dobj recruitment,that
R7295 T9483 T9482 prep of,recruitment
R7296 T9484 T9483 pobj IKKγ,of
R7297 T9485 T9482 prep to,recruitment
R7298 T9486 T9487 det the,CD40
R7299 T9487 T9485 pobj CD40,to
R7300 T9488 T9482 acl signaling,recruitment
R7301 T9489 T9488 dobj complex,signaling
R7302 T9490 T9476 punct .,suggest
R7303 T9491 T9497 prep In,play
R7304 T9492 T9491 pobj addition,In
R7305 T9493 T9497 punct ",",play
R7306 T9494 T9495 compound CD40-associated,HOIP
R7307 T9495 T9497 nsubj HOIP,play
R7308 T9496 T9497 aux could,play
R7309 T9497 T9497 ROOT play,play
R7310 T9498 T9499 det a,role
R7311 T9499 T9497 dobj role,play
R7312 T9500 T9499 prep in,role
R7313 T9501 T9500 pcomp activating,in
R7314 T9502 T9501 dobj IKKγ,activating
R7315 T9503 T9501 prep after,activating
R7316 T9504 T9505 poss its,recruitment
R7317 T9505 T9503 pobj recruitment,after
R7318 T9506 T9497 prep to,play
R7319 T9507 T9508 det the,signaling
R7320 T9508 T9506 pobj signaling,to
R7321 T9509 T9512 amod complex,]
R7322 T9510 T9512 nmod [,]
R7323 T9511 T9510 nummod 16,[
R7324 T9512 T9508 dobj ],signaling
R7325 T9513 T9497 punct .,play
R7326 T9514 T9518 det The,forms
R7327 T9515 T9517 amod higher,weight
R7328 T9516 T9517 amod molecular,weight
R7329 T9517 T9518 compound weight,forms
R7330 T9518 T9527 nsubj forms,be
R7331 T9519 T9518 prep of,forms
R7332 T9520 T9519 pobj IKKγ,of
R7333 T9521 T9522 nsubj we,observed
R7334 T9522 T9518 relcl observed,forms
R7335 T9523 T9522 prep in,observed
R7336 T9524 T9525 nummod CD40,immunoprecipitates
R7337 T9525 T9523 pobj immunoprecipitates,in
R7338 T9526 T9527 aux would,be
R7339 T9527 T9527 ROOT be,be
R7340 T9528 T9527 acomp consistent,be
R7341 T9529 T9528 prep with,consistent
R7342 T9530 T9531 det the,presence
R7343 T9531 T9529 pobj presence,with
R7344 T9532 T9531 prep of,presence
R7345 T9533 T9534 amod post-transcriptional,modifications
R7346 T9534 T9532 pobj modifications,of
R7347 T9535 T9534 prep including,modifications
R7348 T9536 T9535 pobj phosphorylation,including
R7349 T9537 T9536 cc and,phosphorylation
R7350 T9538 T9536 conj ubiquitination,phosphorylation
R7351 T9539 T9536 punct ",",phosphorylation
R7352 T9540 T9543 nsubjpass which,suggested
R7353 T9541 T9543 aux have,suggested
R7354 T9542 T9543 auxpass been,suggested
R7355 T9543 T9534 relcl suggested,modifications
R7356 T9544 T9545 aux to,reduce
R7357 T9545 T9543 xcomp reduce,suggested
R7358 T9546 T9545 cc or,reduce
R7359 T9547 T9545 conj enhance,reduce
R7360 T9548 T9549 amod IKKγ,activity
R7361 T9549 T9547 dobj activity,enhance
R7362 T9550 T9547 punct ",",enhance
R7363 T9551 T9554 advmod respectively,]
R7364 T9552 T9554 nmod [,]
R7365 T9553 T9554 nummod 16,]
R7366 T9554 T9547 npadvmod ],enhance
R7367 T9555 T9554 punct ",",]
R7368 T9556 T9558 nmod [,]
R7369 T9557 T9558 nummod 17,]
R7370 T9558 T9554 appos ],]
R7371 T9559 T9527 punct .,be
R7372 T9560 T9561 det The,mechanisms
R7373 T9561 T9581 nsubj mechanisms,remain
R7374 T9562 T9565 prep by,mediates
R7375 T9563 T9562 pobj which,by
R7376 T9564 T9565 nsubj HOIP,mediates
R7377 T9565 T9561 relcl mediates,mechanisms
R7378 T9566 T9565 dobj recruitment,mediates
R7379 T9567 T9566 prep of,recruitment
R7380 T9568 T9570 det the,complex
R7381 T9569 T9570 compound IKK,complex
R7382 T9570 T9567 pobj complex,of
R7383 T9571 T9570 prep to,complex
R7384 T9572 T9571 pobj CD40,to
R7385 T9573 T9565 cc and,mediates
R7386 T9574 T9578 prep by,recruited
R7387 T9575 T9574 pobj which,by
R7388 T9576 T9578 nsubjpass HOIP,recruited
R7389 T9577 T9578 auxpass is,recruited
R7390 T9578 T9565 conj recruited,mediates
R7391 T9579 T9578 prep to,recruited
R7392 T9580 T9581 nsubj CD40,remain
R7393 T9581 T9581 ROOT remain,remain
R7394 T9582 T9581 acomp unclear,remain
R7395 T9583 T9581 punct .,remain
R7396 T9584 T9586 det A,study
R7397 T9585 T9586 amod previous,study
R7398 T9586 T9587 nsubj study,indicates
R7399 T9587 T9587 ROOT indicates,indicates
R7400 T9588 T9591 mark that,mediate
R7401 T9589 T9591 nsubj HOIP,mediate
R7402 T9590 T9591 aux may,mediate
R7403 T9591 T9587 ccomp mediate,indicates
R7404 T9592 T9593 amod direct,contacts
R7405 T9593 T9591 dobj contacts,mediate
R7406 T9594 T9593 prep with,contacts
R7407 T9595 T9600 det the,]
R7408 T9596 T9598 nmod IKK,[
R7409 T9597 T9598 amod complex,[
R7410 T9598 T9600 nmod [,]
R7411 T9599 T9600 nummod 16,]
R7412 T9600 T9594 pobj ],with
R7413 T9601 T9587 punct ",",indicates
R7414 T9602 T9587 advcl suggesting,indicates
R7415 T9603 T9605 mark that,functions
R7416 T9604 T9605 nsubj it,functions
R7417 T9605 T9602 ccomp functions,suggesting
R7418 T9606 T9605 prep as,functions
R7419 T9607 T9608 det an,adaptor
R7420 T9608 T9606 pobj adaptor,as
R7421 T9609 T9608 prep for,adaptor
R7422 T9610 T9611 det the,recruitment
R7423 T9611 T9609 pobj recruitment,for
R7424 T9612 T9611 prep of,recruitment
R7425 T9613 T9615 det the,complex
R7426 T9614 T9615 compound IKK,complex
R7427 T9615 T9612 pobj complex,of
R7428 T9616 T9615 prep to,complex
R7429 T9617 T9616 pobj CD40,to
R7430 T9618 T9587 punct .,indicates
R7431 T9619 T9627 advmod However,suggests
R7432 T9620 T9627 punct ",",suggests
R7433 T9621 T9624 det the,activity
R7434 T9622 T9624 compound ubiquitin,activity
R7435 T9623 T9624 compound ligase,activity
R7436 T9624 T9627 nsubj activity,suggests
R7437 T9625 T9624 prep of,activity
R7438 T9626 T9625 pobj HOIP,of
R7439 T9627 T9627 ROOT suggests,suggests
R7440 T9628 T9630 mark that,is
R7441 T9629 T9630 nsubj it,is
R7442 T9630 T9627 ccomp is,suggests
R7443 T9631 T9630 acomp more,is
R7444 T9632 T9631 prep than,more
R7445 T9633 T9636 det a,molecule
R7446 T9634 T9636 amod simple,molecule
R7447 T9635 T9636 compound adapter,molecule
R7448 T9636 T9632 pobj molecule,than
R7449 T9637 T9627 punct .,suggests
R7450 T9638 T9640 mark As,appears
R7451 T9639 T9640 nsubj IKKγ,appears
R7452 T9640 T9655 advcl appears,is
R7453 T9641 T9640 oprd capable,appears
R7454 T9642 T9641 prep of,capable
R7455 T9643 T9646 amod binding,[
R7456 T9644 T9645 compound linear,polyubiquitin
R7457 T9645 T9646 compound polyubiquitin,[
R7458 T9646 T9642 pobj [,of
R7459 T9647 T9648 nummod 18,]
R7460 T9648 T9652 nmod ],]
R7461 T9649 T9648 punct ",",]
R7462 T9650 T9648 conj [,]
R7463 T9651 T9652 nummod 19,]
R7464 T9652 T9640 dobj ],appears
R7465 T9653 T9655 punct ",",is
R7466 T9654 T9655 nsubj it,is
R7467 T9655 T9655 ROOT is,is
R7468 T9656 T9655 acomp possible,is
R7469 T9657 T9659 mark that,directs
R7470 T9658 T9659 nsubj HOIP,directs
R7471 T9659 T9655 advcl directs,is
R7472 T9660 T9659 dobj formation,directs
R7473 T9661 T9660 prep of,formation
R7474 T9662 T9664 amod linear,chains
R7475 T9663 T9664 compound polyubiquitin,chains
R7476 T9664 T9661 pobj chains,of
R7477 T9665 T9659 prep on,directs
R7478 T9666 T9668 det a,factor
R7479 T9667 T9668 amod CD40-associated,factor
R7480 T9668 T9665 pobj factor,on
R7481 T9669 T9659 punct ",",directs
R7482 T9670 T9659 cc and,directs
R7483 T9671 T9672 nsubj it,is
R7484 T9672 T9659 conj is,directs
R7485 T9673 T9674 det these,chains
R7486 T9674 T9672 attr chains,is
R7487 T9675 T9676 nsubj that,serve
R7488 T9676 T9674 relcl serve,chains
R7489 T9677 T9678 aux to,recruit
R7490 T9678 T9676 xcomp recruit,serve
R7491 T9679 T9678 dobj IKKγ,recruit
R7492 T9680 T9678 prep to,recruit
R7493 T9681 T9682 det the,CD40
R7494 T9682 T9683 nsubj CD40,signaling
R7495 T9683 T9680 pcomp signaling,to
R7496 T9684 T9683 dobj complex,signaling
R7497 T9685 T9672 punct .,is
R7498 T9686 T9688 det The,interactions
R7499 T9687 T9688 amod molecular,interactions
R7500 T9688 T9701 nsubj interactions,remain
R7501 T9689 T9688 amod necessary,interactions
R7502 T9690 T9689 prep for,necessary
R7503 T9691 T9690 pobj recruitment,for
R7504 T9692 T9691 prep of,recruitment
R7505 T9693 T9692 pobj HOIP,of
R7506 T9694 T9693 appos itself,HOIP
R7507 T9695 T9691 prep to,recruitment
R7508 T9696 T9697 det the,CD40
R7509 T9697 T9699 compound CD40,complex
R7510 T9698 T9699 compound signaling,complex
R7511 T9699 T9695 pobj complex,to
R7512 T9700 T9701 advmod also,remain
R7513 T9701 T9701 ROOT remain,remain
R7514 T9702 T9705 aux to,characterized
R7515 T9703 T9705 auxpass be,characterized
R7516 T9704 T9705 advmod fully,characterized
R7517 T9705 T9701 xcomp characterized,remain
R7518 T9706 T9701 punct .,remain
R7519 T9707 T9709 nsubj We,showed
R7520 T9708 T9709 advmod previously,showed
R7521 T9709 T9709 ROOT showed,showed
R7522 T9710 T9709 dobj that,showed
R7523 T9711 T9712 det the,recruitment
R7524 T9712 T9710 dobj recruitment,that
R7525 T9713 T9712 prep of,recruitment
R7526 T9714 T9713 pobj HOIP,of
R7527 T9715 T9712 prep to,recruitment
R7528 T9716 T9717 det the,signaling
R7529 T9717 T9715 pobj signaling,to
R7530 T9718 T9719 nsubj complex,is
R7531 T9719 T9717 pcomp is,signaling
R7532 T9720 T9721 amod TRAF2-dependent,[
R7533 T9721 T9719 attr [,is
R7534 T9722 T9723 nummod 8,]
R7535 T9723 T9721 appos ],[
R7536 T9724 T9709 punct .,showed
R7537 T9725 T9731 advmod Potentially,interact
R7538 T9726 T9731 punct ",",interact
R7539 T9727 T9731 nsubj TRAF2,interact
R7540 T9728 T9727 cc and,TRAF2
R7541 T9729 T9731 nsubj HOIP,interact
R7542 T9730 T9731 advmod directly,interact
R7543 T9731 T9731 ROOT interact,interact
R7544 T9732 T9731 punct ",",interact
R7545 T9733 T9731 cc but,interact
R7546 T9734 T9735 nsubj it,is
R7547 T9735 T9731 conj is,interact
R7548 T9736 T9735 acomp possible,is
R7549 T9737 T9760 mark that,generates
R7550 T9738 T9741 det the,activity
R7551 T9739 T9741 nmod ubiquitin,activity
R7552 T9740 T9741 compound ligase,activity
R7553 T9741 T9760 nsubj activity,generates
R7554 T9742 T9741 prep of,activity
R7555 T9743 T9746 nummod TRAF2,]
R7556 T9744 T9746 nmod [,]
R7557 T9745 T9746 nummod 20,]
R7558 T9746 T9742 pobj ],of
R7559 T9747 T9746 punct (,]
R7560 T9748 T9746 cc or,]
R7561 T9749 T9750 amod TRAF2-associated,proteins
R7562 T9750 T9746 conj proteins,]
R7563 T9751 T9750 punct ",",proteins
R7564 T9752 T9753 amod such,as
R7565 T9753 T9750 prep as,proteins
R7566 T9754 T9760 det the,generates
R7567 T9755 T9756 compound cIAPs,[
R7568 T9756 T9760 nsubj [,generates
R7569 T9757 T9758 nummod 21,]
R7570 T9758 T9756 appos ],[
R7571 T9759 T9756 punct ),[
R7572 T9760 T9735 ccomp generates,is
R7573 T9761 T9763 amod K63-linked,chains
R7574 T9762 T9763 compound polyubiquitin,chains
R7575 T9763 T9760 dobj chains,generates
R7576 T9764 T9768 prep to,bind
R7577 T9765 T9764 pobj which,to
R7578 T9766 T9768 nsubj HOIP,bind
R7579 T9767 T9768 aux can,bind
R7580 T9768 T9760 advcl bind,generates
R7581 T9769 T9768 cc and,bind
R7582 T9770 T9771 advmod thus,associate
R7583 T9771 T9768 conj associate,bind
R7584 T9772 T9771 prep with,associate
R7585 T9773 T9774 det the,CD40
R7586 T9774 T9775 nsubj CD40,signaling
R7587 T9775 T9772 pcomp signaling,with
R7588 T9776 T9779 amod complex,]
R7589 T9777 T9779 nmod [,]
R7590 T9778 T9777 nummod 22,[
R7591 T9779 T9775 dobj ],signaling
R7592 T9780 T9735 punct .,is
R7593 T9781 T9785 mark While,indicated
R7594 T9782 T9784 poss our,work
R7595 T9783 T9784 amod previous,work
R7596 T9784 T9785 nsubj work,indicated
R7597 T9785 T9804 advcl indicated,are
R7598 T9786 T9789 det a,link
R7599 T9787 T9788 advmod potentially,important
R7600 T9788 T9789 amod important,link
R7601 T9789 T9785 dobj link,indicated
R7602 T9790 T9789 prep between,link
R7603 T9791 T9790 pobj TRAF2,between
R7604 T9792 T9791 cc and,TRAF2
R7605 T9793 T9791 conj HOIP,TRAF2
R7606 T9794 T9793 prep in,HOIP
R7607 T9795 T9794 pobj CD40,in
R7608 T9796 T9793 advcl signaling,HOIP
R7609 T9797 T9796 punct ",",signaling
R7610 T9798 T9799 det the,signals
R7611 T9799 T9796 dobj signals,signaling
R7612 T9800 T9799 cc and,signals
R7613 T9801 T9799 conj functions,signals
R7614 T9802 T9799 acl tested,signals
R7615 T9803 T9802 advmod here,tested
R7616 T9804 T9804 ROOT are,are
R7617 T9805 T9804 acomp dependent,are
R7618 T9806 T9804 prep upon,are
R7619 T9807 T9806 pobj TRAF6,upon
R7620 T9808 T9810 advmod as,as
R7621 T9809 T9810 advmod well,as
R7622 T9810 T9807 cc as,TRAF6
R7623 T9811 T9807 conj TRAF2,TRAF6
R7624 T9812 T9804 punct .,are
R7625 T9813 T9824 prep In,found
R7626 T9814 T9815 amod previous,experiments
R7627 T9815 T9813 pobj experiments,In
R7628 T9816 T9815 prep with,experiments
R7629 T9817 T9821 amod TRAF-deficient,cells
R7630 T9818 T9821 compound A20,cells
R7631 T9819 T9820 compound .2,J
R7632 T9820 T9821 compound J,cells
R7633 T9821 T9816 pobj cells,with
R7634 T9822 T9824 punct ",",found
R7635 T9823 T9824 nsubj we,found
R7636 T9824 T9824 ROOT found,found
R7637 T9825 T9834 mark that,mediated
R7638 T9826 T9827 det the,activation
R7639 T9827 T9834 nsubjpass activation,mediated
R7640 T9828 T9827 prep of,activation
R7641 T9829 T9828 pobj NF-κB,of
R7642 T9830 T9827 prep by,activation
R7643 T9831 T9830 pobj CD40,by
R7644 T9832 T9834 aux could,mediated
R7645 T9833 T9834 auxpass be,mediated
R7646 T9834 T9824 ccomp mediated,found
R7647 T9835 T9834 agent by,mediated
R7648 T9836 T9837 det either,TRAF2
R7649 T9837 T9835 pobj TRAF2,by
R7650 T9838 T9837 cc or,TRAF2
R7651 T9839 T9837 conj TRAF6,TRAF2
R7652 T9840 T9834 punct ",",mediated
R7653 T9841 T9847 mark while,was
R7654 T9842 T9847 nsubj activation,was
R7655 T9843 T9842 prep of,activation
R7656 T9844 T9843 pobj JNK,of
R7657 T9845 T9842 prep by,activation
R7658 T9846 T9845 pobj CD40,by
R7659 T9847 T9834 advcl was,mediated
R7660 T9848 T9849 advmod largely,dependent
R7661 T9849 T9847 acomp dependent,was
R7662 T9850 T9849 prep on,dependent
R7663 T9851 T9855 nummod TRAF6,]
R7664 T9852 T9851 advmod alone,TRAF6
R7665 T9853 T9855 amod [,]
R7666 T9854 T9855 nummod 8,]
R7667 T9855 T9850 pobj ],on
R7668 T9856 T9824 punct .,found
R7669 T9857 T9859 nsubj HOIP,compromises
R7670 T9858 T9859 nsubj deficiency,compromises
R7671 T9859 T9859 ROOT compromises,compromises
R7672 T9860 T9862 det the,activation
R7673 T9861 T9862 amod CD40-mediated,activation
R7674 T9862 T9859 dobj activation,compromises
R7675 T9863 T9862 prep of,activation
R7676 T9864 T9865 preconj both,NF-κB
R7677 T9865 T9863 pobj NF-κB,of
R7678 T9866 T9865 cc and,NF-κB
R7679 T9867 T9865 conj JNK,NF-κB
R7680 T9868 T9859 punct ",",compromises
R7681 T9869 T9859 advcl indicating,compromises
R7682 T9870 T9879 mark that,pass
R7683 T9871 T9879 nsubj signals,pass
R7684 T9872 T9871 acl mediated,signals
R7685 T9873 T9872 agent by,mediated
R7686 T9874 T9875 det both,TRAF2
R7687 T9875 T9873 pobj TRAF2,by
R7688 T9876 T9875 cc and,TRAF2
R7689 T9877 T9875 conj TRAF6,TRAF2
R7690 T9878 T9879 amod likely,pass
R7691 T9879 T9869 ccomp pass,indicating
R7692 T9880 T9879 prep through,pass
R7693 T9881 T9880 pobj HOIP,through
R7694 T9882 T9859 punct .,compromises
R7695 T9883 T9885 poss Our,work
R7696 T9884 T9885 amod previous,work
R7697 T9885 T9887 nsubj work,demonstrated
R7698 T9886 T9887 advmod also,demonstrated
R7699 T9887 T9887 ROOT demonstrated,demonstrated
R7700 T9888 T9902 mark that,compromised
R7701 T9889 T9891 det the,activation
R7702 T9890 T9891 amod CD40-mediated,activation
R7703 T9891 T9902 nsubjpass activation,compromised
R7704 T9892 T9891 prep of,activation
R7705 T9893 T9892 pobj NF-κB,of
R7706 T9894 T9893 cc and,NF-κB
R7707 T9895 T9893 conj JNK,NF-κB
R7708 T9896 T9891 punct ",",activation
R7709 T9897 T9902 mark while,compromised
R7710 T9898 T9902 nsubjpass TRAF6-dependent,compromised
R7711 T9899 T9902 punct ",",compromised
R7712 T9900 T9902 auxpass was,compromised
R7713 T9901 T9902 neg not,compromised
R7714 T9902 T9887 ccomp compromised,demonstrated
R7715 T9903 T9902 agent by,compromised
R7716 T9904 T9905 det the,disruption
R7717 T9905 T9903 pobj disruption,by
R7718 T9906 T9905 prep of,disruption
R7719 T9907 T9909 det the,site
R7720 T9908 T9909 amod binding,site
R7721 T9909 T9906 pobj site,of
R7722 T9910 T9902 prep for,compromised
R7723 T9911 T9910 pobj TRAF6,for
R7724 T9912 T9902 prep in,compromised
R7725 T9913 T9915 det the,domain
R7726 T9914 T9915 amod cytoplasmic,domain
R7727 T9915 T9912 pobj domain,in
R7728 T9916 T9915 prep of,domain
R7729 T9917 T9916 pobj CD40,of
R7730 T9918 T9917 cc or,CD40
R7731 T9919 T9915 conj deletion,domain
R7732 T9920 T9915 prep of,domain
R7733 T9921 T9924 det the,domain
R7734 T9922 T9924 amod receptor,domain
R7735 T9923 T9924 amod binding,domain
R7736 T9924 T9920 pobj domain,of
R7737 T9925 T9924 punct (,domain
R7738 T9926 T9928 det the,domain
R7739 T9927 T9928 compound TRAF-C,domain
R7740 T9928 T9924 appos domain,domain
R7741 T9929 T9924 punct ),domain
R7742 T9930 T9902 prep in,compromised
R7743 T9931 T9933 quantmod TRAF6,8
R7744 T9932 T9933 quantmod [,8
R7745 T9933 T9930 pobj 8,in
R7746 T9934 T9902 npadvmod ],compromised
R7747 T9935 T9887 punct .,demonstrated
R7748 T9936 T9937 det These,observations
R7749 T9937 T9938 nsubj observations,indicate
R7750 T9938 T9938 ROOT indicate,indicate
R7751 T9939 T9944 mark that,bind
R7752 T9940 T9944 nsubj TRAF6,bind
R7753 T9941 T9944 aux need,bind
R7754 T9942 T9944 neg not,bind
R7755 T9943 T9944 advmod directly,bind
R7756 T9944 T9938 ccomp bind,indicate
R7757 T9945 T9944 dobj CD40,bind
R7758 T9946 T9944 prep in,bind
R7759 T9947 T9946 pobj order,in
R7760 T9948 T9949 aux to,mediate
R7761 T9949 T9947 acl mediate,order
R7762 T9950 T9951 amod certain,signals
R7763 T9951 T9949 dobj signals,mediate
R7764 T9952 T9944 punct ",",bind
R7765 T9953 T9938 advcl suggesting,indicate
R7766 T9954 T9955 det the,assembly
R7767 T9955 T9953 dobj assembly,suggesting
R7768 T9956 T9955 prep of,assembly
R7769 T9957 T9959 det a,complex
R7770 T9958 T9959 compound signaling,complex
R7771 T9959 T9956 pobj complex,of
R7772 T9960 T9962 neg not,associated
R7773 T9961 T9962 advmod directly,associated
R7774 T9962 T9959 acl associated,complex
R7775 T9963 T9962 prep with,associated
R7776 T9964 T9965 det the,receptor
R7777 T9965 T9963 pobj receptor,with
R7778 T9966 T9938 punct .,indicate
R7779 T9967 T9971 mark If,exists
R7780 T9968 T9971 predet such,exists
R7781 T9969 T9971 det a,exists
R7782 T9970 T9971 amod complex,exists
R7783 T9971 T9975 advcl exists,indicate
R7784 T9972 T9975 punct ",",indicate
R7785 T9973 T9974 poss our,results
R7786 T9974 T9975 nsubj results,indicate
R7787 T9975 T9975 ROOT indicate,indicate
R7788 T9976 T9981 mark that,compromises
R7789 T9977 T9978 det the,absence
R7790 T9978 T9981 nsubj absence,compromises
R7791 T9979 T9978 prep of,absence
R7792 T9980 T9979 pobj HOIP,of
R7793 T9981 T9975 ccomp compromises,indicate
R7794 T9982 T9983 poss its,function
R7795 T9983 T9981 dobj function,compromises
R7796 T9984 T9985 advmod as,well
R7797 T9985 T9981 advmod well,compromises
R7798 T9986 T9975 punct .,indicate
R7799 T9987 T9990 mark Although,presented
R7800 T9988 T9989 det the,experiments
R7801 T9989 T9990 nsubj experiments,presented
R7802 T9990 T9992 advcl presented,focus
R7803 T9991 T9990 advmod here,presented
R7804 T9992 T9992 ROOT focus,focus
R7805 T9993 T9992 prep on,focus
R7806 T9994 T9993 pobj CD40,on
R7807 T9995 T9994 punct ",",CD40
R7808 T9996 T9997 poss our,results
R7809 T9997 T9994 conj results,CD40
R7810 T9998 T9992 cc and,focus
R7811 T9999 T9992 conj those,focus
R7812 T10000 T9999 prep of,those
R7813 T10001 T10002 amod other,groups
R7814 T10002 T10000 pobj groups,of
R7815 T10003 T10005 nmod [,]
R7816 T10004 T10005 nummod 16,]
R7817 T10005 T9999 conj ],those
R7818 T10006 T10005 punct ",",]
R7819 T10007 T10005 conj [,]
R7820 T10008 T10007 nummod 22,[
R7821 T10009 T10010 amod ],support
R7822 T10010 T10010 ROOT support,support
R7823 T10011 T10012 det the,possibility
R7824 T10012 T10010 dobj possibility,support
R7825 T10013 T10015 mark that,is
R7826 T10014 T10015 nsubj HOIP,is
R7827 T10015 T10012 acl is,possibility
R7828 T10016 T10015 acomp important,is
R7829 T10017 T10015 prep in,is
R7830 T10018 T10020 amod many,pathways
R7831 T10019 T10020 amod signaling,pathways
R7832 T10020 T10017 pobj pathways,in
R7833 T10021 T10027 prep in,involved
R7834 T10022 T10021 pobj which,in
R7835 T10023 T10027 nsubjpass TRAF2,involved
R7836 T10024 T10023 cc or,TRAF2
R7837 T10025 T10023 conj TRAF6,TRAF2
R7838 T10026 T10027 auxpass are,involved
R7839 T10027 T10020 relcl involved,pathways
R7840 T10028 T10027 punct ",",involved
R7841 T10029 T10020 prep including,pathways
R7842 T10030 T10029 pobj those,including
R7843 T10031 T10030 acl associated,those
R7844 T10032 T10031 prep with,associated
R7845 T10033 T10034 amod various,members
R7846 T10034 T10032 pobj members,with
R7847 T10035 T10034 prep of,members
R7848 T10036 T10038 det the,receptor
R7849 T10037 T10038 compound TNF,receptor
R7850 T10038 T10035 pobj receptor,of
R7851 T10039 T10029 pobj superfamily,including
R7852 T10040 T10039 cc and,superfamily
R7853 T10041 T10043 det the,receptors
R7854 T10042 T10043 amod Toll-like,receptors
R7855 T10043 T10039 conj receptors,superfamily
R7856 T10044 T10010 punct .,support
R7857 T10045 T10047 det The,importance
R7858 T10046 T10047 amod potential,importance
R7859 T10047 T10047 ROOT importance,importance
R7860 T10048 T10047 prep of,importance
R7861 T10049 T10048 pobj HOIP,of
R7862 T10050 T10047 prep in,importance
R7863 T10051 T10052 amod immune,function
R7864 T10052 T10050 pobj function,in
R7865 T10053 T10052 cc and,function
R7866 T10054 T10055 compound TNFR,family
R7867 T10055 T10052 conj family,function
R7868 T10056 T10047 acl signaling,importance
R7869 T10057 T10059 auxpass is,supported
R7870 T10058 T10059 advmod further,supported
R7871 T10059 T10056 ccomp supported,signaling
R7872 T10060 T10059 agent by,supported
R7873 T10061 T10063 det the,discovery
R7874 T10062 T10063 amod recent,discovery
R7875 T10063 T10060 pobj discovery,by
R7876 T10064 T10066 dobj that,interacts
R7877 T10065 T10066 nsubj HOIP,interacts
R7878 T10066 T10063 relcl interacts,discovery
R7879 T10067 T10066 prep with,interacts
R7880 T10068 T10069 det a,protein
R7881 T10069 T10067 pobj protein,with
R7882 T10070 T10069 acl known,protein
R7883 T10071 T10070 prep as,known
R7884 T10072 T10071 pobj SHARPIN,as
R7885 T10073 T10072 punct (,SHARPIN
R7886 T10074 T10076 amod SHANK-associated,domain
R7887 T10075 T10076 compound RH,domain
R7888 T10076 T10072 appos domain,SHARPIN
R7889 T10077 T10078 amod interacting,protein
R7890 T10078 T10072 appos protein,SHARPIN
R7891 T10079 T10078 prep in,protein
R7892 T10080 T10081 amod postsynaptic,density
R7893 T10081 T10079 pobj density,in
R7894 T10082 T10072 punct ),SHARPIN
R7895 T10083 T10072 punct ",",SHARPIN
R7896 T10084 T10085 nsubj which,appears
R7897 T10085 T10072 relcl appears,SHARPIN
R7898 T10086 T10085 oprd capable,appears
R7899 T10087 T10086 prep of,capable
R7900 T10088 T10087 pcomp working,of
R7901 T10089 T10090 advmod together,with
R7902 T10090 T10088 prep with,working
R7903 T10091 T10090 pobj HOIP,with
R7904 T10092 T10091 cc and,HOIP
R7905 T10093 T10091 conj HOIL,HOIP
R7906 T10094 T10095 aux to,mediate
R7907 T10095 T10088 advcl mediate,working
R7908 T10096 T10097 det the,assembly
R7909 T10097 T10095 dobj assembly,mediate
R7910 T10098 T10097 prep of,assembly
R7911 T10099 T10100 amod linear,polyubiquitin
R7912 T10100 T10098 pobj polyubiquitin,of
R7913 T10101 T10103 nmod [,]
R7914 T10102 T10103 nummod 14,]
R7915 T10103 T10097 appos ],assembly
R7916 T10104 T10103 punct ",",]
R7917 T10105 T10103 npadvmod [,]
R7918 T10106 T10107 nummod 23,]
R7919 T10107 T10103 conj ],]
R7920 T10108 T10107 punct ",",]
R7921 T10109 T10111 nmod [,]
R7922 T10110 T10111 nummod 24,]
R7923 T10111 T10107 conj ],]
R7924 T10112 T10047 punct .,importance
R7925 T10113 T10134 advmod Interestingly,exhibit
R7926 T10114 T10134 punct ",",exhibit
R7927 T10115 T10134 nsubj mice,exhibit
R7928 T10116 T10115 prep with,mice
R7929 T10117 T10119 det a,mutation
R7930 T10118 T10119 amod spontaneous,mutation
R7931 T10119 T10116 pobj mutation,with
R7932 T10120 T10119 prep in,mutation
R7933 T10121 T10122 det the,gene
R7934 T10122 T10120 pobj gene,in
R7935 T10123 T10134 advcl encoding,exhibit
R7936 T10124 T10123 dobj SHARPIN,encoding
R7937 T10125 T10128 punct (,dermatitis
R7938 T10126 T10128 amod chronic,dermatitis
R7939 T10127 T10128 amod proliferative,dermatitis
R7940 T10128 T10124 appos dermatitis,SHARPIN
R7941 T10129 T10128 punct (,dermatitis
R7942 T10130 T10128 appos cpdm,dermatitis
R7943 T10131 T10128 punct ),dermatitis
R7944 T10132 T10128 appos mice,dermatitis
R7945 T10133 T10128 punct ),dermatitis
R7946 T10134 T10134 ROOT exhibit,exhibit
R7947 T10135 T10136 amod chronic,inflammation
R7948 T10136 T10134 dobj inflammation,exhibit
R7949 T10137 T10136 prep of,inflammation
R7950 T10138 T10139 det the,skin
R7951 T10139 T10145 nmod skin,development
R7952 T10140 T10139 cc and,skin
R7953 T10141 T10142 amod internal,organs
R7954 T10142 T10139 conj organs,skin
R7955 T10143 T10142 punct ",",organs
R7956 T10144 T10145 amod defective,development
R7957 T10145 T10137 pobj development,of
R7958 T10146 T10145 prep of,development
R7959 T10147 T10149 amod secondary,tissue
R7960 T10148 T10149 amod lymphoid,tissue
R7961 T10149 T10146 pobj tissue,of
R7962 T10150 T10134 punct ",",exhibit
R7963 T10151 T10134 cc and,exhibit
R7964 T10152 T10134 conj defects,exhibit
R7965 T10153 T10152 prep in,defects
R7966 T10154 T10155 det the,production
R7967 T10155 T10153 pobj production,in
R7968 T10156 T10155 prep of,production
R7969 T10157 T10159 amod switched,isotypes
R7970 T10158 T10159 compound immunoglobulin,isotypes
R7971 T10159 T10160 compound isotypes,[
R7972 T10160 T10162 nmod [,]
R7973 T10161 T10162 nummod 17,]
R7974 T10162 T10156 pobj ],of
R7975 T10163 T10162 punct ",",]
R7976 T10164 T10166 nmod [,]
R7977 T10165 T10166 nummod 25,]
R7978 T10166 T10162 appos ],]
R7979 T10167 T10134 punct .,exhibit
R7980 T10168 T10172 det The,link
R7981 T10169 T10170 advmod apparently,intimate
R7982 T10170 T10172 amod intimate,link
R7983 T10171 T10172 amod functional,link
R7984 T10172 T10178 nsubj link,suggests
R7985 T10173 T10172 prep between,link
R7986 T10174 T10173 pobj SHARPIN,between
R7987 T10175 T10174 cc and,SHARPIN
R7988 T10176 T10174 conj HOIP,SHARPIN
R7989 T10177 T10178 advmod strongly,suggests
R7990 T10178 T10178 ROOT suggests,suggests
R7991 T10179 T10187 mark that,stems
R7992 T10180 T10181 advmod at,least
R7993 T10181 T10182 advmod least,part
R7994 T10182 T10187 nsubj part,stems
R7995 T10183 T10182 prep of,part
R7996 T10184 T10186 det the,phenotype
R7997 T10185 T10186 compound cpdm,phenotype
R7998 T10186 T10183 pobj phenotype,of
R7999 T10187 T10178 ccomp stems,suggests
R8000 T10188 T10187 prep from,stems
R8001 T10189 T10188 pobj defects,from
R8002 T10190 T10189 prep in,defects
R8003 T10191 T10192 det the,regulation
R8004 T10192 T10190 pobj regulation,in
R8005 T10193 T10192 cc or,regulation
R8006 T10194 T10192 conj function,regulation
R8007 T10195 T10192 prep of,regulation
R8008 T10196 T10195 pobj HOIP,of
R8009 T10197 T10178 punct .,suggests

UBERON-AE

Id Subject Object Predicate Lexical cue
T9058 1075-1088 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T9059 5280-5286 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organs
T9060 5323-5338 http://purl.obolibrary.org/obo/UBERON_0001744 denotes lymphoid tissue
T9061 5332-5338 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

GO-BP

Id Subject Object Predicate Lexical cue
T11273 83-90 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T11274 3349-3356 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T11275 3744-3751 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T11276 4196-4203 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T11277 4234-4243 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T11278 4560-4569 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T11279 4794-4803 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T11280 156-164 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T11281 960-968 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T11282 233-242 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T11283 2561-2570 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T11284 365-399 http://purl.obolibrary.org/obo/GO_0016064 denotes antibody-mediated immune responses
T11285 365-399 http://purl.obolibrary.org/obo/GO_0002455 denotes antibody-mediated immune responses
T11286 374-399 http://purl.obolibrary.org/obo/GO_0002443 denotes mediated immune responses
T11287 383-399 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T11288 981-997 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T11289 490-512 http://purl.obolibrary.org/obo/GO_0023035 denotes CD40 signaling pathway
T11290 889-911 http://purl.obolibrary.org/obo/GO_0023035 denotes CD40 signaling pathway
T11291 490-512 http://purl.obolibrary.org/obo/GO_2000348 denotes CD40 signaling pathway
T11292 889-911 http://purl.obolibrary.org/obo/GO_2000348 denotes CD40 signaling pathway
T11293 495-512 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T11294 894-911 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T11295 4560-4578 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T11296 578-581 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T11297 2098-2101 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T11298 2247-2250 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T11299 2335-2338 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T11300 634-653 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T11301 1433-1452 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T11302 3502-3521 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T11303 3870-3889 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T11304 759-762 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T11305 3594-3597 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T11306 3723-3726 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T11307 3894-3897 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T11308 973-997 http://purl.obolibrary.org/obo/GO_0002922 denotes humoral immune responses
T11309 973-997 http://purl.obolibrary.org/obo/GO_0006959 denotes humoral immune responses
T11310 973-997 http://purl.obolibrary.org/obo/GO_0002920 denotes humoral immune responses
T11311 973-997 http://purl.obolibrary.org/obo/GO_0002921 denotes humoral immune responses
T11312 1057-1067 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T11313 5568-5578 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T11314 1057-1088 http://purl.obolibrary.org/obo/GO_0002682 denotes regulation of the immune system
T11315 1312-1325 http://purl.obolibrary.org/obo/GO_0000209 denotes polyubiquitin
T11316 2502-2515 http://purl.obolibrary.org/obo/GO_0000209 denotes polyubiquitin
T11317 2581-2594 http://purl.obolibrary.org/obo/GO_0000209 denotes polyubiquitin
T11318 3139-3152 http://purl.obolibrary.org/obo/GO_0000209 denotes polyubiquitin
T11319 5070-5083 http://purl.obolibrary.org/obo/GO_0000209 denotes polyubiquitin
T11320 1878-1893 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T11321 1918-1933 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T11322 2369-2394 http://purl.obolibrary.org/obo/GO_0004842 denotes ubiquitin ligase activity
T11323 3023-3048 http://purl.obolibrary.org/obo/GO_0004842 denotes ubiquitin ligase activity
T11324 2369-2394 http://purl.obolibrary.org/obo/GO_0050372 denotes ubiquitin ligase activity
T11325 3023-3048 http://purl.obolibrary.org/obo/GO_0050372 denotes ubiquitin ligase activity
T11326 2369-2394 http://purl.obolibrary.org/obo/GO_1904666 denotes ubiquitin ligase activity
T11327 3023-3048 http://purl.obolibrary.org/obo/GO_1904666 denotes ubiquitin ligase activity
T11328 2369-2394 http://purl.obolibrary.org/obo/GO_1990757 denotes ubiquitin ligase activity
T11329 3023-3048 http://purl.obolibrary.org/obo/GO_1990757 denotes ubiquitin ligase activity
T11330 2369-2394 http://purl.obolibrary.org/obo/GO_1904668 denotes ubiquitin ligase activity
T11331 3023-3048 http://purl.obolibrary.org/obo/GO_1904668 denotes ubiquitin ligase activity
T11332 2369-2394 http://purl.obolibrary.org/obo/GO_0061630 denotes ubiquitin ligase activity
T11333 3023-3048 http://purl.obolibrary.org/obo/GO_0061630 denotes ubiquitin ligase activity
T11334 2369-2394 http://purl.obolibrary.org/obo/GO_1904667 denotes ubiquitin ligase activity
T11335 3023-3048 http://purl.obolibrary.org/obo/GO_1904667 denotes ubiquitin ligase activity
T11336 2369-2394 http://purl.obolibrary.org/obo/GO_0034450 denotes ubiquitin ligase activity
T11337 3023-3048 http://purl.obolibrary.org/obo/GO_0034450 denotes ubiquitin ligase activity
T11338 2379-2394 http://purl.obolibrary.org/obo/GO_0016874 denotes ligase activity
T11339 3033-3048 http://purl.obolibrary.org/obo/GO_0016874 denotes ligase activity
T11340 4220-4251 http://purl.obolibrary.org/obo/GO_0007172 denotes assembly of a signaling complex
T11341 4220-4251 http://purl.obolibrary.org/obo/GO_1904745 denotes assembly of a signaling complex
T11342 5242-5254 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T11343 5298-5309 http://purl.obolibrary.org/obo/GO_0032502 denotes development

GO-MF

Id Subject Object Predicate Lexical cue
T11345 280-294 http://purl.obolibrary.org/obo/GO_0003823 denotes immunoglobulin
T11346 365-373 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T11347 578-581 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T11348 2098-2101 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T11349 2247-2250 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T11350 2335-2338 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T11351 759-762 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T11352 3594-3597 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T11353 3723-3726 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T11354 3894-3897 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T11355 2369-2378 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T11356 3023-3032 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T11357 2369-2394 http://purl.obolibrary.org/obo/GO_0004842 denotes ubiquitin ligase activity
T11358 3023-3048 http://purl.obolibrary.org/obo/GO_0004842 denotes ubiquitin ligase activity
T11359 2369-2394 http://purl.obolibrary.org/obo/GO_0050372 denotes ubiquitin ligase activity
T11360 3023-3048 http://purl.obolibrary.org/obo/GO_0050372 denotes ubiquitin ligase activity
T11361 2369-2394 http://purl.obolibrary.org/obo/GO_1990757 denotes ubiquitin ligase activity
T11362 3023-3048 http://purl.obolibrary.org/obo/GO_1990757 denotes ubiquitin ligase activity
T11363 2369-2394 http://purl.obolibrary.org/obo/GO_0061630 denotes ubiquitin ligase activity
T11364 3023-3048 http://purl.obolibrary.org/obo/GO_0061630 denotes ubiquitin ligase activity
T11365 2369-2394 http://purl.obolibrary.org/obo/GO_0034450 denotes ubiquitin ligase activity
T11366 3023-3048 http://purl.obolibrary.org/obo/GO_0034450 denotes ubiquitin ligase activity
T11367 2379-2394 http://purl.obolibrary.org/obo/GO_0016874 denotes ligase activity
T11368 3033-3048 http://purl.obolibrary.org/obo/GO_0016874 denotes ligase activity
T11369 2487-2494 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T11370 3967-3974 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T11371 4052-4059 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T11372 2487-2515 http://purl.obolibrary.org/obo/GO_1990450 denotes binding linear polyubiquitin
T11373 4043-4059 http://purl.obolibrary.org/obo/GO_0005102 denotes receptor binding
T11374 4052-4076 http://purl.obolibrary.org/obo/GO_0044198 denotes binding domain (the TRAF
T11375 4672-4696 http://purl.obolibrary.org/obo/GO_0032813 denotes TNF receptor superfamily

GO-CC

Id Subject Object Predicate Lexical cue
T11376 107-111 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T11377 350-354 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T11378 3477-3482 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11379 365-373 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T11380 365-373 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T11381 578-589 http://purl.obolibrary.org/obo/GO_0008385 denotes IKK complex
T11382 2098-2109 http://purl.obolibrary.org/obo/GO_0008385 denotes IKK complex
T11383 2247-2258 http://purl.obolibrary.org/obo/GO_0008385 denotes IKK complex
T11384 2335-2346 http://purl.obolibrary.org/obo/GO_0008385 denotes IKK complex
T11385 1265-1280 http://purl.obolibrary.org/obo/GO_0043234 denotes protein complex
T11386 1559-1575 http://purl.obolibrary.org/obo/GO_0016592 denotes complex mediates
T11387 4952-4972 http://purl.obolibrary.org/obo/GO_0014069 denotes postsynaptic density

sentences

Id Subject Object Predicate Lexical cue
T9192 11-121 Sentence denotes Our results indicate that the protein HOIP is critical for CD40-induced signals that regulate B cell function.
T9193 122-400 Sentence denotes Our data show that HOIP-dependent cellular responses include CD40-mediated upregulation of CD80 expression and synthesis of germline RNA transcripts from the immunoglobulin heavy chain locus, two events that are important for T-cell-dependent antibody-mediated immune responses.
T9194 401-598 Sentence denotes At the molecular level, our data indicate that HOIP functions downstream of TRAF2 in the CD40 signaling pathway and that HOIP has a key role in promoting the recruitment of the IKK complex to CD40.
T9195 599-691 Sentence denotes Consistent with this, CD40-induced activation of NF-κB is dependent on the presence of HOIP.
T9196 692-794 Sentence denotes In addition, our data show that HOIP facilitates the activation of JNK in response to CD40 engagement.
T9197 795-912 Sentence denotes Together, our findings provide support for the conclusion that HOIP is a key component of the CD40 signaling pathway.
T9198 913-1089 Sentence denotes Given the importance of CD40 signaling in both cellular and humoral immune responses, our results indicate that HOIP has a critical role in the regulation of the immune system.
T9199 1090-1163 Sentence denotes The functional properties of HOIP have only been partially characterized.
T9200 1164-1337 Sentence denotes Initial studies showed that HOIP and the related protein HOIL-1 are components of a large (∼600 kDa) protein complex capable of synthesizing linear polyubiquitin chains [5].
T9201 1338-1484 Sentence denotes Subsequent studies showed that a HOIP-containing complex can interact with IKKγ and facilitate activation of NF-κB via the canonical pathway [16].
T9202 1485-1626 Sentence denotes These data, considered together with ours, suggest that a HOIP-containing complex mediates recruitment of IKKγ to the CD40 signaling complex.
T9203 1627-1750 Sentence denotes In addition, CD40-associated HOIP could play a role in activating IKKγ after its recruitment to the signaling complex [16].
T9204 1751-2040 Sentence denotes The higher molecular weight forms of IKKγ we observed in CD40 immunoprecipitates would be consistent with the presence of post-transcriptional modifications including phosphorylation and ubiquitination, which have been suggested to reduce or enhance IKKγ activity, respectively [16], [17].
T9205 2041-2172 Sentence denotes The mechanisms by which HOIP mediates recruitment of the IKK complex to CD40 and by which HOIP is recruited to CD40 remain unclear.
T9206 2173-2355 Sentence denotes A previous study indicates that HOIP may mediate direct contacts with the IKK complex [16], suggesting that it functions as an adaptor for the recruitment of the IKK complex to CD40.
T9207 2356-2459 Sentence denotes However, the ubiquitin ligase activity of HOIP suggests that it is more than a simple adapter molecule.
T9208 2460-2711 Sentence denotes As IKKγ appears capable of binding linear polyubiquitin [18], [19], it is possible that HOIP directs formation of linear polyubiquitin chains on a CD40-associated factor, and it is these chains that serve to recruit IKKγ to the CD40 signaling complex.
T9209 2712-2848 Sentence denotes The molecular interactions necessary for recruitment of HOIP itself to the CD40 signaling complex also remain to be fully characterized.
T9210 2849-2947 Sentence denotes We previously showed that the recruitment of HOIP to the signaling complex is TRAF2-dependent [8].
T9211 2948-3239 Sentence denotes Potentially, TRAF2 and HOIP directly interact, but it is possible that the ubiquitin ligase activity of TRAF2 [20] (or TRAF2-associated proteins, such as the cIAPs [21]) generates K63-linked polyubiquitin chains to which HOIP can bind and thus associate with the CD40 signaling complex [22].
T9212 3240-3425 Sentence denotes While our previous work indicated a potentially important link between TRAF2 and HOIP in CD40 signaling, the signals and functions tested here are dependent upon TRAF6 as well as TRAF2.
T9213 3426-3647 Sentence denotes In previous experiments with TRAF-deficient A20.2J cells, we found that the activation of NF-κB by CD40 could be mediated by either TRAF2 or TRAF6, while activation of JNK by CD40 was largely dependent on TRAF6 alone [8].
T9214 3648-3810 Sentence denotes HOIP deficiency compromises the CD40-mediated activation of both NF-κB and JNK, indicating that signals mediated by both TRAF2 and TRAF6 likely pass through HOIP.
T9215 3811-4100 Sentence denotes Our previous work also demonstrated that the CD40-mediated activation of NF-κB and JNK, while TRAF6-dependent, was not compromised by the disruption of the binding site for TRAF6 in the cytoplasmic domain of CD40 or deletion of the receptor binding domain (the TRAF-C domain) in TRAF6 [8].
T9216 4101-4294 Sentence denotes These observations indicate that TRAF6 need not directly bind CD40 in order to mediate certain signals, suggesting the assembly of a signaling complex not directly associated with the receptor.
T9217 4295-4400 Sentence denotes If such a complex exists, our results indicate that the absence of HOIP compromises its function as well.
T9218 4401-4725 Sentence denotes Although the experiments presented here focus on CD40, our results and those of other groups [16], [22] support the possibility that HOIP is important in many signaling pathways in which TRAF2 or TRAF6 are involved, including those associated with various members of the TNF receptor superfamily and the Toll-like receptors.
T9219 4726-5101 Sentence denotes The potential importance of HOIP in immune function and TNFR family signaling is further supported by the recent discovery that HOIP interacts with a protein known as SHARPIN (SHANK-associated RH domain interacting protein in postsynaptic density), which appears capable of working together with HOIP and HOIL to mediate the assembly of linear polyubiquitin [14], [23], [24].
T9220 5102-5417 Sentence denotes Interestingly, mice with a spontaneous mutation in the gene encoding SHARPIN (chronic proliferative dermatitis (cpdm) mice) exhibit chronic inflammation of the skin and internal organs, defective development of secondary lymphoid tissue, and defects in the production of switched immunoglobulin isotypes [17], [25].
T9221 5418-5599 Sentence denotes The apparently intimate functional link between SHARPIN and HOIP strongly suggests that at least part of the cpdm phenotype stems from defects in the regulation or function of HOIP.
T149 0-10 Sentence denotes Discussion
T150 11-121 Sentence denotes Our results indicate that the protein HOIP is critical for CD40-induced signals that regulate B cell function.
T151 122-400 Sentence denotes Our data show that HOIP-dependent cellular responses include CD40-mediated upregulation of CD80 expression and synthesis of germline RNA transcripts from the immunoglobulin heavy chain locus, two events that are important for T-cell-dependent antibody-mediated immune responses.
T152 401-598 Sentence denotes At the molecular level, our data indicate that HOIP functions downstream of TRAF2 in the CD40 signaling pathway and that HOIP has a key role in promoting the recruitment of the IKK complex to CD40.
T153 599-691 Sentence denotes Consistent with this, CD40-induced activation of NF-κB is dependent on the presence of HOIP.
T154 692-794 Sentence denotes In addition, our data show that HOIP facilitates the activation of JNK in response to CD40 engagement.
T155 795-912 Sentence denotes Together, our findings provide support for the conclusion that HOIP is a key component of the CD40 signaling pathway.
T156 913-1089 Sentence denotes Given the importance of CD40 signaling in both cellular and humoral immune responses, our results indicate that HOIP has a critical role in the regulation of the immune system.
T157 1090-1163 Sentence denotes The functional properties of HOIP have only been partially characterized.
T158 1164-1337 Sentence denotes Initial studies showed that HOIP and the related protein HOIL-1 are components of a large (∼600 kDa) protein complex capable of synthesizing linear polyubiquitin chains [5].
T159 1338-1484 Sentence denotes Subsequent studies showed that a HOIP-containing complex can interact with IKKγ and facilitate activation of NF-κB via the canonical pathway [16].
T160 1485-1626 Sentence denotes These data, considered together with ours, suggest that a HOIP-containing complex mediates recruitment of IKKγ to the CD40 signaling complex.
T161 1627-1750 Sentence denotes In addition, CD40-associated HOIP could play a role in activating IKKγ after its recruitment to the signaling complex [16].
T162 1751-2040 Sentence denotes The higher molecular weight forms of IKKγ we observed in CD40 immunoprecipitates would be consistent with the presence of post-transcriptional modifications including phosphorylation and ubiquitination, which have been suggested to reduce or enhance IKKγ activity, respectively [16], [17].
T163 2041-2172 Sentence denotes The mechanisms by which HOIP mediates recruitment of the IKK complex to CD40 and by which HOIP is recruited to CD40 remain unclear.
T164 2173-2355 Sentence denotes A previous study indicates that HOIP may mediate direct contacts with the IKK complex [16], suggesting that it functions as an adaptor for the recruitment of the IKK complex to CD40.
T165 2356-2459 Sentence denotes However, the ubiquitin ligase activity of HOIP suggests that it is more than a simple adapter molecule.
T166 2460-2711 Sentence denotes As IKKγ appears capable of binding linear polyubiquitin [18], [19], it is possible that HOIP directs formation of linear polyubiquitin chains on a CD40-associated factor, and it is these chains that serve to recruit IKKγ to the CD40 signaling complex.
T167 2712-2848 Sentence denotes The molecular interactions necessary for recruitment of HOIP itself to the CD40 signaling complex also remain to be fully characterized.
T168 2849-2947 Sentence denotes We previously showed that the recruitment of HOIP to the signaling complex is TRAF2-dependent [8].
T169 2948-3239 Sentence denotes Potentially, TRAF2 and HOIP directly interact, but it is possible that the ubiquitin ligase activity of TRAF2 [20] (or TRAF2-associated proteins, such as the cIAPs [21]) generates K63-linked polyubiquitin chains to which HOIP can bind and thus associate with the CD40 signaling complex [22].
T170 3240-3425 Sentence denotes While our previous work indicated a potentially important link between TRAF2 and HOIP in CD40 signaling, the signals and functions tested here are dependent upon TRAF6 as well as TRAF2.
T171 3426-3647 Sentence denotes In previous experiments with TRAF-deficient A20.2J cells, we found that the activation of NF-κB by CD40 could be mediated by either TRAF2 or TRAF6, while activation of JNK by CD40 was largely dependent on TRAF6 alone [8].
T172 3648-3810 Sentence denotes HOIP deficiency compromises the CD40-mediated activation of both NF-κB and JNK, indicating that signals mediated by both TRAF2 and TRAF6 likely pass through HOIP.
T173 3811-4100 Sentence denotes Our previous work also demonstrated that the CD40-mediated activation of NF-κB and JNK, while TRAF6-dependent, was not compromised by the disruption of the binding site for TRAF6 in the cytoplasmic domain of CD40 or deletion of the receptor binding domain (the TRAF-C domain) in TRAF6 [8].
T174 4101-4294 Sentence denotes These observations indicate that TRAF6 need not directly bind CD40 in order to mediate certain signals, suggesting the assembly of a signaling complex not directly associated with the receptor.
T175 4295-4400 Sentence denotes If such a complex exists, our results indicate that the absence of HOIP compromises its function as well.
T176 4401-4725 Sentence denotes Although the experiments presented here focus on CD40, our results and those of other groups [16], [22] support the possibility that HOIP is important in many signaling pathways in which TRAF2 or TRAF6 are involved, including those associated with various members of the TNF receptor superfamily and the Toll-like receptors.
T177 4726-5101 Sentence denotes The potential importance of HOIP in immune function and TNFR family signaling is further supported by the recent discovery that HOIP interacts with a protein known as SHARPIN (SHANK-associated RH domain interacting protein in postsynaptic density), which appears capable of working together with HOIP and HOIL to mediate the assembly of linear polyubiquitin [14], [23], [24].
T178 5102-5417 Sentence denotes Interestingly, mice with a spontaneous mutation in the gene encoding SHARPIN (chronic proliferative dermatitis (cpdm) mice) exhibit chronic inflammation of the skin and internal organs, defective development of secondary lymphoid tissue, and defects in the production of switched immunoglobulin isotypes [17], [25].
T179 5418-5599 Sentence denotes The apparently intimate functional link between SHARPIN and HOIP strongly suggests that at least part of the cpdm phenotype stems from defects in the regulation or function of HOIP.

ICD10

Id Subject Object Predicate Lexical cue
T11344 5202-5212 http://purl.bioontology.org/ontology/ICD10/L30.9 denotes dermatitis

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T11149 49-53 Q96EP0 denotes HOIP
T11150 70-74 P25942 denotes CD40
T11151 141-145 Q96EP0 denotes HOIP
T11152 183-187 P25942 denotes CD40
T11153 213-217 P33681 denotes CD80
T11154 280-306 P01854 denotes immunoglobulin heavy chain
T11155 280-306 P01876 denotes immunoglobulin heavy chain
T11156 280-306 P01877 denotes immunoglobulin heavy chain
T11157 280-306 P01871 denotes immunoglobulin heavy chain
T11158 280-306 P01861 denotes immunoglobulin heavy chain
T11159 280-306 P01860 denotes immunoglobulin heavy chain
T11160 280-306 P01859 denotes immunoglobulin heavy chain
T11161 280-306 P01857 denotes immunoglobulin heavy chain
T11162 280-306 P01880 denotes immunoglobulin heavy chain
T11163 448-452 Q96EP0 denotes HOIP
T11164 477-482 Q12933 denotes TRAF2
T11165 490-494 P25942 denotes CD40
T11166 522-526 Q96EP0 denotes HOIP
T11167 593-597 P25942 denotes CD40
T11168 621-625 P25942 denotes CD40
T11169 686-690 Q96EP0 denotes HOIP
T11170 724-728 Q96EP0 denotes HOIP
T11171 778-782 P25942 denotes CD40
T11172 858-862 Q96EP0 denotes HOIP
T11173 889-893 P25942 denotes CD40
T11174 937-941 P25942 denotes CD40
T11175 1025-1029 Q96EP0 denotes HOIP
T11176 1119-1123 Q96EP0 denotes HOIP
T11177 1192-1196 Q96EP0 denotes HOIP
T11178 1221-1227 Q9BYM8 denotes HOIL-1
T11179 1371-1375 Q96EP0 denotes HOIP
T11180 1543-1547 Q96EP0 denotes HOIP
T11181 1603-1607 P25942 denotes CD40
T11182 1640-1644 P25942 denotes CD40
T11183 1656-1660 Q96EP0 denotes HOIP
T11184 1808-1812 P25942 denotes CD40
T11185 2065-2069 Q96EP0 denotes HOIP
T11186 2113-2117 P25942 denotes CD40
T11187 2131-2135 Q96EP0 denotes HOIP
T11188 2152-2156 P25942 denotes CD40
T11189 2205-2209 Q96EP0 denotes HOIP
T11190 2350-2354 P25942 denotes CD40
T11191 2398-2402 Q96EP0 denotes HOIP
T11192 2548-2552 Q96EP0 denotes HOIP
T11193 2607-2611 P25942 denotes CD40
T11194 2688-2692 P25942 denotes CD40
T11195 2768-2772 Q96EP0 denotes HOIP
T11196 2787-2791 P25942 denotes CD40
T11197 2894-2898 Q96EP0 denotes HOIP
T11198 2927-2932 Q12933 denotes TRAF2
T11199 2961-2966 Q12933 denotes TRAF2
T11200 2971-2975 Q96EP0 denotes HOIP
T11201 3052-3057 Q12933 denotes TRAF2
T11202 3067-3072 Q12933 denotes TRAF2
T11203 3169-3173 Q96EP0 denotes HOIP
T11204 3211-3215 P25942 denotes CD40
T11205 3311-3316 Q12933 denotes TRAF2
T11206 3321-3325 Q96EP0 denotes HOIP
T11207 3329-3333 P25942 denotes CD40
T11208 3402-3407 Q9Y4K3 denotes TRAF6
T11209 3419-3424 Q12933 denotes TRAF2
T11210 3470-3473 P21580 denotes A20
T11211 3525-3529 P25942 denotes CD40
T11212 3558-3563 Q12933 denotes TRAF2
T11213 3567-3572 Q9Y4K3 denotes TRAF6
T11214 3601-3605 P25942 denotes CD40
T11215 3631-3636 Q9Y4K3 denotes TRAF6
T11216 3648-3652 Q96EP0 denotes HOIP
T11217 3680-3684 P25942 denotes CD40
T11218 3769-3774 Q12933 denotes TRAF2
T11219 3779-3784 Q9Y4K3 denotes TRAF6
T11220 3805-3809 Q96EP0 denotes HOIP
T11221 3856-3860 P25942 denotes CD40
T11222 3905-3910 Q9Y4K3 denotes TRAF6
T11223 3984-3989 Q9Y4K3 denotes TRAF6
T11224 4019-4023 P25942 denotes CD40
T11225 4090-4095 Q9Y4K3 denotes TRAF6
T11226 4134-4139 Q9Y4K3 denotes TRAF6
T11227 4163-4167 P25942 denotes CD40
T11228 4362-4366 Q96EP0 denotes HOIP
T11229 4450-4454 P25942 denotes CD40
T11230 4534-4538 Q96EP0 denotes HOIP
T11231 4588-4593 Q12933 denotes TRAF2
T11232 4597-4602 Q9Y4K3 denotes TRAF6
T11233 4672-4675 P01375 denotes TNF
T11234 4754-4758 Q96EP0 denotes HOIP
T11235 4854-4858 Q96EP0 denotes HOIP
T11236 4893-4900 Q9H0F6 denotes SHARPIN
T11237 4908-4951 Q9H0F6 denotes associated RH domain interacting protein in
T11238 5022-5026 Q96EP0 denotes HOIP
T11239 5171-5178 Q9H0F6 denotes SHARPIN
T11240 5466-5473 Q9H0F6 denotes SHARPIN
T11241 5478-5482 Q96EP0 denotes HOIP
T11242 5594-5598 Q96EP0 denotes HOIP

test2

Id Subject Object Predicate Lexical cue Speculation
T8930 49-53 Protein denotes HOIP true
T8931 70-74 Protein denotes CD40 true
T8932 141-145 Protein denotes HOIP
T8933 183-187 Protein denotes CD40
T8934 188-196 Positive_regulation denotes mediated
T8935 197-209 Positive_regulation denotes upregulation
T8936 213-217 Protein denotes CD80
T8937 218-228 Gene_expression denotes expression
T8938 448-452 Protein denotes HOIP
T8939 463-473 Regulation denotes downstream
T8940 477-482 Protein denotes TRAF2
T8941 490-494 Protein denotes CD40
T8942 522-526 Protein denotes HOIP
T8943 537-541 Regulation denotes role
T8944 545-554 Positive_regulation denotes promoting
T8945 559-570 Binding denotes recruitment
T8946 593-597 Protein denotes CD40
T8947 621-625 Protein denotes CD40
T8948 724-728 Protein denotes HOIP
T8949 778-782 Protein denotes CD40
T8950 783-793 Binding denotes engagement
T8951 858-862 Protein denotes HOIP
T8952 889-893 Protein denotes CD40
T8953 937-941 Protein denotes CD40
T8954 1025-1029 Protein denotes HOIP
T8955 1119-1123 Protein denotes HOIP
T8956 1192-1196 Protein denotes HOIP
T8957 1221-1227 Protein denotes HOIL-1 true
T8958 1399-1407 Binding denotes interact
T8959 1413-1417 Protein denotes IKKγ
T8960 1567-1575 Positive_regulation denotes mediates
T8961 1576-1587 Binding denotes recruitment
T8962 1591-1595 Protein denotes IKKγ
T8963 1640-1644 Protein denotes CD40
T8964 1645-1655 Binding denotes associated
T8965 1656-1660 Protein denotes HOIP
T8966 1674-1678 Regulation denotes role
T8967 1682-1692 Positive_regulation denotes activating
T8968 1693-1697 Protein denotes IKKγ
T8969 1708-1719 Binding denotes recruitment
T8970 1788-1792 Protein denotes IKKγ
T8971 1808-1812 Protein denotes CD40
T8972 1993-2000 Positive_regulation denotes enhance
T8973 2001-2005 Protein denotes IKKγ
T8974 2065-2069 Protein denotes HOIP true
T8975 2070-2078 Positive_regulation denotes mediates
T8976 2079-2090 Binding denotes recruitment
T8977 2113-2117 Protein denotes CD40
T8978 2131-2135 Protein denotes HOIP
T8979 2139-2148 Binding denotes recruited
T8980 2152-2156 Protein denotes CD40
T8981 2205-2209 Protein denotes HOIP
T8982 2284-2307 Positive_regulation denotes functions as an adaptor
T8983 2316-2327 Binding denotes recruitment
T8984 2350-2354 Protein denotes CD40
T8985 2398-2402 Protein denotes HOIP
T8986 2463-2467 Protein denotes IKKγ
T8987 2548-2552 Protein denotes HOIP
T8988 2668-2675 Binding denotes recruit
T8989 2676-2680 Protein denotes IKKγ
T8990 2739-2748 Positive_regulation denotes necessary
T8991 2753-2764 Binding denotes recruitment
T8992 2768-2772 Protein denotes HOIP
T8993 2879-2890 Binding denotes recruitment
T8994 2894-2898 Protein denotes HOIP
T8995 2927-2932 Protein denotes TRAF2
T8996 2933-2942 Regulation denotes dependent
T8997 2961-2966 Protein denotes TRAF2
T8998 2971-2975 Protein denotes HOIP
T8999 2985-2993 Binding denotes interact
T9000 3052-3057 Protein denotes TRAF2
T9001 3169-3173 Protein denotes HOIP
T9002 3178-3182 Binding denotes bind
T9003 3192-3201 Binding denotes associate
T9004 3311-3316 Protein denotes TRAF2
T9005 3321-3325 Protein denotes HOIP
T9006 3329-3333 Protein denotes CD40
T9007 3387-3396 Regulation denotes dependent
T9008 3402-3407 Protein denotes TRAF6
T9009 3419-3424 Protein denotes TRAF2
T9010 3460-3469 Negative_regulation denotes deficient
T9011 3525-3529 Protein denotes CD40
T9012 3539-3547 Positive_regulation denotes mediated
T9013 3558-3563 Protein denotes TRAF2
T9014 3567-3572 Protein denotes TRAF6
T9015 3601-3605 Protein denotes CD40
T9016 3618-3627 Regulation denotes dependent
T9017 3631-3636 Protein denotes TRAF6
T9018 3648-3652 Protein denotes HOIP
T9019 3653-3663 Negative_regulation denotes deficiency
T9020 3680-3684 Protein denotes CD40
T9021 3769-3774 Protein denotes TRAF2
T9022 3779-3784 Protein denotes TRAF6
T9023 3805-3809 Protein denotes HOIP
T9024 3856-3860 Protein denotes CD40
T9025 3905-3910 Protein denotes TRAF6
T9026 3911-3920 Regulation denotes dependent
T9027 3930-3941 Negative_regulation denotes compromised
T9028 3949-3959 Negative_regulation denotes disruption
T9029 3967-3979 Entity denotes binding site
T9030 3984-3989 Protein denotes TRAF6
T9031 3997-4015 Entity denotes cytoplasmic domain
T9032 4019-4023 Protein denotes CD40
T9033 4027-4035 Negative_regulation denotes deletion
T9034 4043-4066 Entity denotes receptor binding domain
T9035 4090-4095 Protein denotes TRAF6
T9036 4134-4139 Protein denotes TRAF6
T9037 4158-4162 Binding denotes bind
T9038 4163-4167 Protein denotes CD40
T9039 4351-4358 Negative_regulation denotes absence
T9040 4362-4366 Protein denotes HOIP
T9041 4450-4454 Protein denotes CD40
T9042 4534-4538 Protein denotes HOIP
T9043 4588-4593 Protein denotes TRAF2
T9044 4597-4602 Protein denotes TRAF6
T9045 4633-4643 Binding denotes associated
T9046 4754-4758 Protein denotes HOIP
T9047 4854-4858 Protein denotes HOIP
T9048 4859-4868 Binding denotes interacts
T9049 4893-4900 Protein denotes SHARPIN
T9050 4902-4972 Protein denotes SHANK-associated RH domain interacting protein in postsynaptic density
T9051 5022-5026 Protein denotes HOIP
T9052 5031-5035 Protein denotes HOIL
T9053 5171-5178 Protein denotes SHARPIN
T9054 5466-5473 Protein denotes SHARPIN
T9055 5478-5482 Protein denotes HOIP
T9056 5568-5578 Regulation denotes regulation
T9057 5594-5598 Protein denotes HOIP
R6910 T8933 T8934 causeOf CD40,mediated
R6911 T8935 T8934 themeOf upregulation,mediated
R6912 T8936 T8937 themeOf CD80,expression
R6913 T8937 T8935 themeOf expression,upregulation
R6914 T8940 T8939 causeOf TRAF2,downstream
R6915 T8942 T8943 causeOf HOIP,role
R6916 T8945 T8944 themeOf recruitment,promoting
R6917 T8946 T8945 themeOf CD40,recruitment
R6918 T8949 T8950 themeOf CD40,engagement
R6919 T8959 T8958 themeOf IKKγ,interact
R6920 T8961 T8960 themeOf recruitment,mediates
R6921 T8962 T8961 themeOf IKKγ,recruitment
R6922 T8963 T8964 themeOf CD40,associated
R6923 T8965 T8964 themeOf HOIP,associated
R6924 T8965 T8969 themeOf HOIP,recruitment
R6925 T8967 T8966 themeOf activating,role
R6926 T8968 T8967 themeOf IKKγ,activating
R6927 T8973 T8972 themeOf IKKγ,enhance
R6928 T8974 T8975 causeOf HOIP,mediates
R6929 T8976 T8975 themeOf recruitment,mediates
R6930 T8977 T8976 themeOf CD40,recruitment
R6931 T8978 T8979 themeOf HOIP,recruited
R6932 T8980 T8979 themeOf CD40,recruited
R6933 T8981 T8982 causeOf HOIP,functions as an adaptor
R6934 T8983 T8982 themeOf recruitment,functions as an adaptor
R6935 T8984 T8983 themeOf CD40,recruitment
R6936 T8989 T8988 themeOf IKKγ,recruit
R6937 T8991 T8990 themeOf recruitment,necessary
R6938 T8992 T8991 themeOf HOIP,recruitment
R6939 T8993 T8996 themeOf recruitment,dependent
R6940 T8994 T8993 themeOf HOIP,recruitment
R6941 T8997 T8999 themeOf TRAF2,interact
R6942 T8998 T8999 themeOf HOIP,interact
R6943 T9001 T9002 themeOf HOIP,bind
R6944 T9001 T9003 themeOf HOIP,associate
R6945 T9009 T9007 causeOf TRAF2,dependent
R6946 T9013 T9012 causeOf TRAF2,mediated
R6947 T9014 T9012 causeOf TRAF6,mediated
R6948 T9017 T9016 causeOf TRAF6,dependent
R6949 T9018 T9019 themeOf HOIP,deficiency
R6951 T9028 T9027 causeOf disruption,compromised
R6952 T9029 T9030 partOf binding site,TRAF6
R6953 T9029 T9028 themeOf binding site,disruption
R6954 T9033 T9027 causeOf deletion,compromised
R6955 T9034 T9033 themeOf receptor binding domain,deletion
R6956 T9034 T9035 partOf receptor binding domain,TRAF6
R6950 T9026 T9027 themeOf dependent,compromised
R6957 T9036 T9037 themeOf TRAF6,bind
R6958 T9038 T9037 themeOf CD40,bind
R6959 T9040 T9039 themeOf HOIP,absence
R6960 T9042 T9045 themeOf HOIP,associated
R6961 T9043 T9045 themeOf TRAF2,associated
R6962 T9044 T9045 themeOf TRAF6,associated
R6963 T9047 T9048 themeOf HOIP,interacts
R6964 T9049 T9048 themeOf SHARPIN,interacts
R6965 T9050 T9049 equivalentTo SHANK-associated RH domain interacting protein in postsynaptic density,SHARPIN
R6966 T9057 T9056 themeOf HOIP,regulation