PMC:3148254 / 1857-4900 JSON TXT

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bionlp-st-ge-2016-reference

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T1114	13-17	Protein	denotes	CD40
T1115	225-229	Protein	denotes	CD40
T1116	301-305	Protein	denotes	CD40
T1117	307-312	Protein	denotes	CD154
T1118	317-326	Gene_expression	denotes	expressed
T1119	359-363	Protein	denotes	CD40
T1120	364-374	Binding	denotes	engagement
T1121	627-631	Protein	denotes	CD40
T1122	702-720	Entity	denotes	cytoplasmic domain
T1123	724-728	Protein	denotes	CD40
T1124	828-839	Binding	denotes	recruitment
T1125	946-951	Protein	denotes	TRAF1
T1126	953-958	Protein	denotes	TRAF2
T1127	960-965	Protein	denotes	TRAF3
T1128	971-976	Protein	denotes	TRAF6
T1129	1051-1055	Protein	denotes	CD40
T1130	1125-1132	Binding	denotes	binding
T1131	1125-1132	Binding	denotes	binding
T1132	1125-1132	Binding	denotes	binding
T1133	1125-1132	Binding	denotes	binding
T1134	1140-1156	Entity	denotes	cytoplasmic tail
T1135	1160-1164	Protein	denotes	CD40
T1136	1399-1408	Binding	denotes	associate
T1137	1399-1408	Binding	denotes	associate
T1138	1399-1408	Binding	denotes	associate
T1139	1414-1418	Protein	denotes	CD40
T1140	1420-1425	Protein	denotes	TRAF3
T1141	1483-1488	Protein	denotes	TRAF2
T1142	1493-1498	Protein	denotes	TRAF6
T1143	1590-1617	Protein	denotes	HOIL-1L interacting protein
T1144	1619-1623	Protein	denotes	HOIP
T1145	1715-1724	Binding	denotes	recruited
T1146	1728-1732	Protein	denotes	CD40
T1147	1738-1743	Protein	denotes	TRAF2
T1148	1744-1753	Regulation	denotes	dependent
T1149	1761-1770	Positive_regulation	denotes	following
T1150	1771-1781	Binding	denotes	engagement
T1151	1785-1789	Protein	denotes	CD40
T1152	1869-1873	Protein	denotes	HOIP
T1153	1874-1894	Positive_regulation	denotes	functions downstream		true
T1154	1898-1903	Protein	denotes	TRAF2
T1155	1911-1915	Protein	denotes	CD40
T1156	1943-1947	Protein	denotes	HOIP
T1157	2097-2103	Negative_regulation	denotes	ablate
T1158	2104-2114	Gene_expression	denotes	expression
T1159	2118-2122	Protein	denotes	HOIP
T1160	2194-2198	Protein	denotes	CD40
T1161	2242-2246	Protein	denotes	CD40
T1162	2247-2254	Positive_regulation	denotes	induced
T1163	2255-2267	Positive_regulation	denotes	upregulation
T1164	2271-2275	Protein	denotes	CD80
T1165	2319-2328	Negative_regulation	denotes	defective
T1166	2332-2336	Protein	denotes	HOIP
T1167	2337-2346	Negative_regulation	denotes	deficient
T1168	2369-2373	Protein	denotes	CD40
T1169	2378-2382	Protein	denotes	IL-4
T1170	2577-2584	Negative_regulation	denotes	absence
T1171	2588-2592	Protein	denotes	HOIP
T1172	2617-2621	Protein	denotes	CD40
T1173	2727-2731	Protein	denotes	HOIP
T1174	2732-2741	Negative_regulation	denotes	deficient
T1175	2792-2803	Binding	denotes	association	true
T1176	2841-2845	Protein	denotes	CD40
T1177	2866-2870	Protein	denotes	HOIP
T1178	2871-2880	Negative_regulation	denotes	deficient
T1179	2924-2928	Protein	denotes	HOIP
T1180	3027-3031	Protein	denotes	CD40
T1181	3032-3042	Binding	denotes	engagement
T6574	1943-1947	Protein	denotes	HOIP
T6575	1951-1960	Positive_regulation	denotes	necessary
T6576	2792-2803	Binding	denotes	association
R776	T1117	T1118	themeOf	CD154,expressed
R777	T1119	T1120	themeOf	CD40,engagement
R778	T1122	T1124	themeOf	cytoplasmic domain,recruitment
R779	T1122	T1123	partOf	cytoplasmic domain,CD40
R780	T1125	T1131	themeOf	TRAF1,binding
R781	T1126	T1132	themeOf	TRAF2,binding
R782	T1127	T1133	themeOf	TRAF3,binding
R783	T1128	T1130	themeOf	TRAF6,binding
R784	T1134	T1131	themeOf	cytoplasmic tail,binding
R785	T1134	T1135	partOf	cytoplasmic tail,CD40
R786	T1134	T1132	themeOf	cytoplasmic tail,binding
R787	T1134	T1133	themeOf	cytoplasmic tail,binding
R788	T1134	T1130	themeOf	cytoplasmic tail,binding
R789	T1139	T1137	themeOf	CD40,associate
R790	T1139	T1136	themeOf	CD40,associate
R791	T1139	T1138	themeOf	CD40,associate
R792	T1140	T1137	themeOf	TRAF3,associate
R793	T1141	T1136	themeOf	TRAF2,associate
R794	T1142	T1138	themeOf	TRAF6,associate
R795	T1143	T1145	themeOf	HOIL-1L interacting protein,recruited
R796	T1144	T1143	equivalentTo	HOIP,HOIL-1L interacting protein
R797	T1145	T1148	themeOf	recruited,dependent
R798	T1146	T1145	themeOf	CD40,recruited
R799	T1147	T1148	causeOf	TRAF2,dependent
R800	T1148	T1149	themeOf	dependent,following
R801	T1150	T1149	causeOf	engagement,following
R802	T1151	T1150	themeOf	CD40,engagement
R803	T1152	T1153	causeOf	HOIP,functions downstream
R804	T1154	T1153	themeOf	TRAF2,functions downstream
R805	T1158	T1157	themeOf	expression,ablate
R806	T1159	T1158	themeOf	HOIP,expression
R807	T1161	T1162	causeOf	CD40,induced
R808	T1162	T1165	themeOf	induced,defective
R809	T1163	T1162	themeOf	upregulation,induced
R810	T1164	T1163	themeOf	CD80,upregulation
R811	T1166	T1167	themeOf	HOIP,deficient
R812	T1171	T1170	themeOf	HOIP,absence
R813	T1173	T1174	themeOf	HOIP,deficient
R814	T1176	T1175	themeOf	CD40,association
R815	T1177	T1178	themeOf	HOIP,deficient
R816	T1180	T1181	themeOf	CD40,engagement
R5001	T6574	T6575	causeOf	HOIP,necessary
R5002	T6576	T6575	themeOf	association,necessary

bionlp-st-ge-2016-reference-tees

Id	Subject	Object	Predicate	Lexical cue
T2561	13-17	Protein	denotes	CD40
T2562	225-229	Protein	denotes	CD40
T2563	301-305	Protein	denotes	CD40
T2564	307-312	Protein	denotes	CD154
T2565	243-252	Positive_regulation	denotes	activated
T2566	317-326	Gene_expression	denotes	expressed
T2567	317-326	Gene_expression	denotes	expressed
T2568	359-363	Protein	denotes	CD40
T2569	441-473	Protein	denotes	stress-activated protein kinases
T2570	482-508	Protein	denotes	transcription factor NF-κB
T2571	364-374	Binding	denotes	engagement
T2572	627-631	Protein	denotes	CD40
T2573	724-728	Protein	denotes	CD40
T2574	890-920	Protein	denotes	TNF receptor-associated factor
T2575	922-926	Protein	denotes	TRAF
T2576	946-951	Protein	denotes	TRAF1
T2577	953-958	Protein	denotes	TRAF2
T2578	960-965	Protein	denotes	TRAF3
T2579	971-976	Protein	denotes	TRAF6
T2580	1051-1055	Protein	denotes	CD40
T2581	928-934	Entity	denotes	family
T2582	1004-1013	Regulation	denotes	important
T2583	1004-1013	Regulation	denotes	important
T2584	1004-1013	Regulation	denotes	important
T2585	1004-1013	Regulation	denotes	important
T2586	1004-1013	Regulation	denotes	important
T2587	1004-1013	Regulation	denotes	important
T2588	1004-1013	Regulation	denotes	important
T2589	1004-1013	Regulation	denotes	important
T2590	1160-1164	Protein	denotes	CD40
T2591	1125-1132	Binding	denotes	binding
T2592	1243-1248	Protein	denotes	TRAFs
T2593	1266-1268	Protein	denotes	E3
T2594	1269-1286	Protein	denotes	ubiquitin ligases
T2595	1388-1393	Protein	denotes	TRAFs
T2596	1414-1418	Protein	denotes	CD40
T2597	1420-1425	Protein	denotes	TRAF3
T2598	1483-1488	Protein	denotes	TRAF2
T2599	1493-1498	Protein	denotes	TRAF6
T2600	1399-1408	Binding	denotes	associate
T2601	1590-1617	Protein	denotes	HOIL-1L interacting protein
T2602	1619-1623	Protein	denotes	HOIP
T2603	1628-1644	Protein	denotes	ubiquitin ligase
T2604	1728-1732	Protein	denotes	CD40
T2605	1738-1743	Protein	denotes	TRAF2
T2606	1785-1789	Protein	denotes	CD40
T2607	1715-1724	Binding	denotes	recruited
T2608	1715-1724	Binding	denotes	recruited
T2609	1715-1724	Binding	denotes	recruited
T2610	1771-1781	Binding	denotes	engagement
T2611	1898-1903	Protein	denotes	TRAF2
T2612	1911-1915	Protein	denotes	CD40
T2613	1983-1988	Protein	denotes	NF-κB
T2614	1969-1979	Positive_regulation	denotes	activation
T2615	1951-1960	Positive_regulation	denotes	necessary
T2616	2187-2198	Protein	denotes	B cell CD40
T2617	2242-2246	Protein	denotes	CD40
T2618	2271-2275	Protein	denotes	CD80
T2619	2369-2373	Protein	denotes	CD40
T2620	2378-2382	Protein	denotes	IL-4
T2621	2434-2474	Protein	denotes	immunoglobulin epsilon heavy chain locus
T2622	2499-2518	Protein	denotes	immunoglobulin gene
T2623	2390-2400	Gene_expression	denotes	production
T2624	2390-2400	Gene_expression	denotes	production
T2625	2390-2400	Gene_expression	denotes	production
T2626	2617-2621	Protein	denotes	CD40
T2627	2645-2650	Protein	denotes	NF-κB
T2628	2676-2703	Protein	denotes	protein kinase c-Jun kinase
T2629	2705-2708	Protein	denotes	JNK
T2630	2631-2641	Positive_regulation	denotes	activation
T2631	2659-2675	Positive_regulation	denotes	stress-activated
T2632	2714-2723	Negative_regulation	denotes	defective
T2633	2631-2641	Positive_regulation	denotes	activation
T2634	2774-2779	Protein	denotes	NF-κB
T2635	2811-2821	Protein	denotes	IκB kinase
T2636	2823-2826	Protein	denotes	IKK
T2637	2841-2845	Protein	denotes	CD40
T2638	2780-2790	Positive_regulation	denotes	activation
T2639	2792-2803	Binding	denotes	association
T2640	2792-2803	Binding	denotes	association
T2641	2792-2803	Binding	denotes	association
T2642	3027-3042	Protein	denotes	CD40 engagement
T8614	2792-2803	Binding	denotes	association
T8615	1951-1960	Positive_regulation	denotes	necessary
R1955	T2574	T2582	themeOf	TNF receptor-associated factor,important
R1957	T2574	T2584	themeOf	TNF receptor-associated factor,important
R1958	T2574	T2586	themeOf	TNF receptor-associated factor,important
R1959	T2574	T2588	themeOf	TNF receptor-associated factor,important
R1960	T2574	T2581	partOf	TNF receptor-associated factor,family
R1961	T2575	T2583	themeOf	TRAF,important
R1962	T2575	T2585	themeOf	TRAF,important
R1963	T2575	T2587	themeOf	TRAF,important
R1964	T2575	T2589	themeOf	TRAF,important
R1965	T2575	T2581	partOf	TRAF,family
R1966	T2562	T2565	themeOf	CD40,activated
R1967	T2576	T2582	causeOf	TRAF1,important
R1968	T2563	T2566	themeOf	CD40,expressed
R1969	T2564	T2567	themeOf	CD154,expressed
R1970	T2568	T2571	themeOf	CD40,engagement
R1971	T2576	T2583	causeOf	TRAF1,important
R1972	T2577	T2584	causeOf	TRAF2,important
R1973	T2577	T2585	causeOf	TRAF2,important
R1974	T2578	T2586	causeOf	TRAF3,important
R1975	T2578	T2587	causeOf	TRAF3,important
R1976	T2579	T2588	causeOf	TRAF6,important
R1977	T2613	T2614	themeOf	NF-κB,activation
R1978	T2579	T2589	causeOf	TRAF6,important
R1979	T2614	T2615	themeOf	activation,necessary
R1980	T2581	T2582	Site	family,important
R1981	T2581	T2583	Site	family,important
R1982	T2619	T2623	themeOf	CD40,production
R1983	T2620	T2624	themeOf	IL-4,production
R1984	T2581	T2584	Site	family,important
R1985	T2621	T2625	themeOf	immunoglobulin epsilon heavy chain locus,production
R1986	T2581	T2585	Site	family,important
R1987	T2581	T2586	Site	family,important
R1988	T2581	T2587	Site	family,important
R1989	T2581	T2588	Site	family,important
R1990	T2581	T2589	Site	family,important
R1991	T2626	T2630	causeOf	CD40,activation
R1992	T2626	T2633	causeOf	CD40,activation
R1993	T2627	T2630	themeOf	NF-κB,activation
R1994	T2590	T2591	themeOf	CD40,binding
R1995	T2630	T2631	themeOf	activation,stress-activated
R1996	T2630	T2632	themeOf	activation,defective
R1997	T2631	T2633	themeOf	stress-activated,activation
R1998	T2634	T2638	themeOf	NF-κB,activation
R1999	T2635	T2640	themeOf	IκB kinase,association
R2000	T2636	T2641	themeOf	IKK,association
R2001	T2637	T2639	themeOf	CD40,association
R2002	T2637	T2640	themeOf	CD40,association
R2003	T2637	T2641	themeOf	CD40,association
R2004	T2595	T2600	themeOf	TRAFs,associate
R2005	T2596	T2600	themeOf	CD40,associate
R2006	T2601	T2607	themeOf	HOIL-1L interacting protein,recruited
R2007	T2602	T2608	themeOf	HOIP,recruited
R2008	T2603	T2609	themeOf	ubiquitin ligase,recruited
R2009	T2604	T2607	themeOf	CD40,recruited
R2011	T2604	T2608	themeOf	CD40,recruited
R2013	T2604	T2609	themeOf	CD40,recruited
R2014	T2606	T2610	themeOf	CD40,engagement
R6749	T8614	T8615	themeOf	association,necessary

events-check-again

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T2643	13-17	Protein	denotes	CD40
T2644	225-229	Protein	denotes	CD40
T2645	301-305	Protein	denotes	CD40
T2646	307-312	Protein	denotes	CD154
T2647	317-326	Gene_expression	denotes	expressed
T2648	359-363	Protein	denotes	CD40
T2649	364-374	Binding	denotes	engagement
T2650	627-631	Protein	denotes	CD40
T2651	702-720	Entity	denotes	cytoplasmic domain
T2652	724-728	Protein	denotes	CD40
T2653	828-839	Binding	denotes	recruitment
T2654	946-951	Protein	denotes	TRAF1
T2655	953-958	Protein	denotes	TRAF2
T2656	960-965	Protein	denotes	TRAF3
T2657	971-976	Protein	denotes	TRAF6
T2658	1051-1055	Protein	denotes	CD40
T2659	1125-1132	Binding	denotes	binding
T2660	1125-1132	Binding	denotes	binding
T2661	1125-1132	Binding	denotes	binding
T2662	1125-1132	Binding	denotes	binding
T2663	1140-1156	Entity	denotes	cytoplasmic tail
T2664	1160-1164	Protein	denotes	CD40
T2665	1399-1408	Binding	denotes	associate
T2666	1399-1408	Binding	denotes	associate
T2667	1399-1408	Binding	denotes	associate
T2668	1414-1418	Protein	denotes	CD40
T2669	1420-1425	Protein	denotes	TRAF3
T2670	1483-1488	Protein	denotes	TRAF2
T2671	1493-1498	Protein	denotes	TRAF6
T2672	1590-1617	Protein	denotes	HOIL-1L interacting protein
T2673	1619-1623	Protein	denotes	HOIP
T2674	1715-1724	Binding	denotes	recruited
T2675	1728-1732	Protein	denotes	CD40
T2676	1738-1743	Protein	denotes	TRAF2
T2677	1744-1753	Regulation	denotes	dependent
T2678	1761-1770	Positive_regulation	denotes	following
T2679	1771-1781	Binding	denotes	engagement
T2680	1785-1789	Protein	denotes	CD40
T2681	1869-1873	Protein	denotes	HOIP
T2682	1874-1894	Positive_regulation	denotes	functions downstream		true
T2683	1898-1903	Protein	denotes	TRAF2
T2684	1911-1915	Protein	denotes	CD40
T2685	1943-1947	Protein	denotes	HOIP
T2686	2097-2103	Negative_regulation	denotes	ablate
T2687	2104-2114	Gene_expression	denotes	expression
T2688	2118-2122	Protein	denotes	HOIP
T2689	2194-2198	Protein	denotes	CD40
T2690	2242-2246	Protein	denotes	CD40
T2691	2247-2254	Positive_regulation	denotes	induced
T2692	2255-2267	Positive_regulation	denotes	upregulation
T2693	2271-2275	Protein	denotes	CD80
T2694	2319-2328	Negative_regulation	denotes	defective
T2695	2332-2336	Protein	denotes	HOIP
T2696	2337-2346	Negative_regulation	denotes	deficient
T2697	2369-2373	Protein	denotes	CD40
T2698	2378-2382	Protein	denotes	IL-4
T2699	2577-2584	Negative_regulation	denotes	absence
T2700	2588-2592	Protein	denotes	HOIP
T2701	2617-2621	Protein	denotes	CD40
T2702	2727-2731	Protein	denotes	HOIP
T2703	2732-2741	Negative_regulation	denotes	deficient
T2704	2792-2803	Binding	denotes	association	true
T2705	2841-2845	Protein	denotes	CD40
T2706	2866-2870	Protein	denotes	HOIP
T2707	2871-2880	Negative_regulation	denotes	deficient
T2708	2924-2928	Protein	denotes	HOIP
T2709	3027-3031	Protein	denotes	CD40
T2710	3032-3042	Binding	denotes	engagement
T8586	1943-1947	Protein	denotes	HOIP
T8587	1951-1960	Positive_regulation	denotes	necessary
T8588	2792-2803	Binding	denotes	association
R2010	T2646	T2647	themeOf	CD154,expressed
R2012	T2648	T2649	themeOf	CD40,engagement
R2015	T2651	T2653	themeOf	cytoplasmic domain,recruitment
R2016	T2651	T2652	partOf	cytoplasmic domain,CD40
R2017	T2680	T2679	themeOf	CD40,engagement
R2018	T2654	T2660	themeOf	TRAF1,binding
R2019	T2655	T2661	themeOf	TRAF2,binding
R2020	T2656	T2662	themeOf	TRAF3,binding
R2021	T2657	T2659	themeOf	TRAF6,binding
R2022	T2663	T2660	themeOf	cytoplasmic tail,binding
R2023	T2663	T2664	partOf	cytoplasmic tail,CD40
R2024	T2663	T2661	themeOf	cytoplasmic tail,binding
R2025	T2663	T2662	themeOf	cytoplasmic tail,binding
R2026	T2663	T2659	themeOf	cytoplasmic tail,binding
R2027	T2681	T2682	causeOf	HOIP,functions downstream
R2028	T2668	T2666	themeOf	CD40,associate
R2029	T2668	T2665	themeOf	CD40,associate
R2030	T2668	T2667	themeOf	CD40,associate
R2031	T2669	T2666	themeOf	TRAF3,associate
R2032	T2670	T2665	themeOf	TRAF2,associate
R2033	T2671	T2667	themeOf	TRAF6,associate
R2034	T2683	T2682	themeOf	TRAF2,functions downstream
R2035	T2672	T2674	themeOf	HOIL-1L interacting protein,recruited
R2036	T2673	T2672	equivalentTo	HOIP,HOIL-1L interacting protein
R2037	T2687	T2686	themeOf	expression,ablate
R2038	T2674	T2677	themeOf	recruited,dependent
R2039	T2675	T2674	themeOf	CD40,recruited
R2040	T2676	T2677	causeOf	TRAF2,dependent
R2041	T2677	T2678	themeOf	dependent,following
R2042	T2688	T2687	themeOf	HOIP,expression
R2043	T2679	T2678	causeOf	engagement,following
R2044	T2690	T2691	causeOf	CD40,induced
R2045	T2691	T2694	themeOf	induced,defective
R2046	T2692	T2691	themeOf	upregulation,induced
R2047	T2693	T2692	themeOf	CD80,upregulation
R2048	T2695	T2696	themeOf	HOIP,deficient
R2049	T2700	T2699	themeOf	HOIP,absence
R2050	T2702	T2703	themeOf	HOIP,deficient
R2051	T2705	T2704	themeOf	CD40,association
R2052	T2706	T2707	themeOf	HOIP,deficient
R2053	T2709	T2710	themeOf	CD40,engagement
R6718	T8586	T8587	causeOf	HOIP,necessary
R6719	T8588	T8587	themeOf	association,necessary

bionlp-st-ge-2016-coref

Id	Subject	Object	Predicate	Lexical cue
T2237	960-965	Antecedent	denotes	TRAF3
T2238	971-976	Antecedent	denotes	TRAF6
T2239	1375-1393	Anaphor	denotes	the multiple TRAFs
T2240	1420-1425	Antecedent	denotes	TRAF3
T2241	1483-1488	Antecedent	denotes	TRAF2
T2242	1493-1498	Antecedent	denotes	TRAF6
T2243	1394-1398	Anaphor	denotes	that
T2244	1375-1393	Antecedent	denotes	the multiple TRAFs
T2234	1071-1085	Anaphor	denotes	These proteins
T2235	946-951	Antecedent	denotes	TRAF1
T2236	953-958	Antecedent	denotes	TRAF2
R1832	T2234	T2237	boundBy	These proteins,TRAF3
R1833	T2234	T2238	boundBy	These proteins,TRAF6
R1836	T2239	T2240	boundBy	the multiple TRAFs,TRAF3
R1837	T2239	T2241	boundBy	the multiple TRAFs,TRAF2
R1838	T2239	T2242	boundBy	the multiple TRAFs,TRAF6
R1840	T2243	T2239	boundBy	that,the multiple TRAFs
R1830	T2234	T2235	boundBy	These proteins,TRAF1
R1831	T2234	T2236	boundBy	These proteins,TRAF2

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T1725	13-17	NN	denotes	CD40
T1726	18-27	NN	denotes	signaling
T1727	28-30	IN	denotes	in
T1728	31-43	JJ	denotes	professional
T1729	44-62	JJ	denotes	antigen-presenting
T1730	63-68	NN	denotes	cells
T1731	68-69	-COMMA-	denotes	,
T1732	70-79	VB	denotes	including
T1733	80-81	NN	denotes	B
T1734	82-87	NN	denotes	cells
T1735	87-88	-COMMA-	denotes	,
T1736	89-100	NN	denotes	macrophages
T1737	100-101	-COMMA-	denotes	,
T1738	102-105	CC	denotes	and
T1739	106-115	JJ	denotes	dendritic
T1740	116-121	NN	denotes	cells
T1741	121-122	-COMMA-	denotes	,
T1742	123-125	VB	denotes	is
T1743	126-134	JJ	denotes	critical
T1744	135-138	IN	denotes	for
T1745	139-142	DT	denotes	the
T1746	143-152	JJ	denotes	efficient
T1747	153-163	NN	denotes	activation
T1748	164-166	IN	denotes	of
T1749	167-174	JJ	denotes	humoral
T1750	175-178	CC	denotes	and
T1751	179-192	JJ	denotes	cell-mediated
T1752	193-199	JJ	denotes	immune
T1753	200-209	NN	denotes	responses
T1754	210-211	-LRB-	denotes	[
T1755	211-212	CD	denotes	1
T1756	212-213	-RRB-	denotes	]
T1757	213-214	-COMMA-	denotes	,
T1758	215-216	-LRB-	denotes	[
T1759	216-217	CD	denotes	2
T1760	217-218	-RRB-	denotes	]
T1761	218-219	-COMMA-	denotes	,
T1762	220-221	-LRB-	denotes	[
T1763	221-222	CD	denotes	3
T1764	222-223	-RRB-	denotes	]
T1765	225-229	NN	denotes	CD40
T1766	230-239	NN	denotes	signaling
T1767	240-242	VB	denotes	is
T1768	243-252	VB	denotes	activated
T1769	253-255	IN	denotes	in
T1770	256-257	DT	denotes	a
T1771	258-259	NN	denotes	T
T1772	260-274	JJ	denotes	cell-dependent
T1773	275-281	NN	denotes	manner
T1774	281-282	-COMMA-	denotes	,
T1775	283-285	IN	denotes	as
T1776	286-289	DT	denotes	the
T1777	290-296	NN	denotes	ligand
T1778	297-300	IN	denotes	for
T1779	301-305	NN	denotes	CD40
T1780	305-306	-COMMA-	denotes	,
T1781	307-312	NN	denotes	CD154
T1782	312-313	-COMMA-	denotes	,
T1783	314-316	VB	denotes	is
T1784	317-326	VB	denotes	expressed
T1785	327-336	RB	denotes	primarily
T1786	337-339	IN	denotes	by
T1787	340-349	VB	denotes	activated
T1788	350-351	NN	denotes	T
T1789	352-357	NN	denotes	cells
T1790	359-363	NN	denotes	CD40
T1791	364-374	NN	denotes	engagement
T1792	375-380	VB	denotes	leads
T1793	381-383	TO	denotes	to
T1794	384-387	DT	denotes	the
T1795	388-398	NN	denotes	activation
T1796	399-401	IN	denotes	of
T1797	402-409	JJ	denotes	various
T1798	410-419	VB	denotes	signaling
T1799	420-429	NN	denotes	molecules
T1800	429-430	-COMMA-	denotes	,
T1801	431-440	VB	denotes	including
T1802	441-457	JJ	denotes	stress-activated
T1803	458-465	NN	denotes	protein
T1804	466-473	NN	denotes	kinases
T1805	474-477	CC	denotes	and
T1806	478-481	DT	denotes	the
T1807	482-495	NN	denotes	transcription
T1808	496-502	NN	denotes	factor
T1809	503-508	NN	denotes	NF-κB
T1810	508-509	-COMMA-	denotes	,
T1811	510-515	WDT	denotes	which
T1812	516-526	VB	denotes	upregulate
T1813	527-530	DT	denotes	the
T1814	531-541	NN	denotes	expression
T1815	542-544	IN	denotes	of
T1816	545-554	NN	denotes	cytokines
T1817	555-558	CC	denotes	and
T1818	559-564	JJ	denotes	other
T1819	565-572	NN	denotes	factors
T1820	573-577	WDT	denotes	that
T1821	578-585	VB	denotes	promote
T1822	586-592	JJ	denotes	immune
T1823	593-602	NN	denotes	responses
T1824	604-607	DT	denotes	The
T1825	608-617	NN	denotes	mechanism
T1826	618-620	IN	denotes	by
T1827	621-626	WDT	denotes	which
T1828	627-631	NN	denotes	CD40
T1829	632-639	VB	denotes	induces
T1830	640-645	DT	denotes	these
T1831	646-655	NN	denotes	signaling
T1832	656-664	NN	denotes	pathways
T1833	665-668	VB	denotes	has
T1834	669-672	RB	denotes	not
T1835	673-677	VB	denotes	been
T1836	678-688	RB	denotes	completely
T1837	689-696	VB	denotes	defined
T1838	698-701	DT	denotes	The
T1839	702-713	JJ	denotes	cytoplasmic
T1840	714-720	NN	denotes	domain
T1841	721-723	IN	denotes	of
T1842	724-728	NN	denotes	CD40
T1843	729-733	VB	denotes	does
T1844	734-737	RB	denotes	not
T1845	738-744	VB	denotes	appear
T1846	745-747	TO	denotes	to
T1847	748-752	VB	denotes	have
T1848	753-762	JJ	denotes	intrinsic
T1849	763-772	JJ	denotes	enzymatic
T1850	773-781	NN	denotes	activity
T1851	781-782	-COMMA-	denotes	,
T1852	783-786	CC	denotes	but
T1853	787-789	VB	denotes	is
T1854	790-794	JJ	denotes	able
T1855	795-797	TO	denotes	to
T1856	798-805	VB	denotes	mediate
T1857	806-815	NN	denotes	signaling
T1858	816-823	IN	denotes	through
T1859	824-827	DT	denotes	the
T1860	828-839	NN	denotes	recruitment
T1861	840-842	IN	denotes	of
T1862	843-850	JJ	denotes	several
T1863	851-864	JJ	denotes	intracellular
T1864	865-873	NN	denotes	proteins
T1865	875-882	NN	denotes	Members
T1866	883-885	IN	denotes	of
T1867	886-889	DT	denotes	the
T1868	890-893	NN	denotes	TNF
T1869	894-913	JJ	denotes	receptor-associated
T1870	914-920	NN	denotes	factor
T1871	921-922	-LRB-	denotes	(
T1872	922-926	NN	denotes	TRAF
T1873	926-927	-RRB-	denotes	)
T1874	928-934	NN	denotes	family
T1875	934-935	-COMMA-	denotes	,
T1876	936-945	VB	denotes	including
T1877	946-951	NN	denotes	TRAF1
T1878	951-952	-COMMA-	denotes	,
T1879	953-958	NN	denotes	TRAF2
T1880	958-959	-COMMA-	denotes	,
T1881	960-965	NN	denotes	TRAF3
T1882	965-966	-COMMA-	denotes	,
T1883	967-970	CC	denotes	and
T1884	971-976	NN	denotes	TRAF6
T1885	976-977	-COMMA-	denotes	,
T1886	978-984	VB	denotes	appear
T1887	985-987	TO	denotes	to
T1888	988-990	VB	denotes	be
T1889	991-1003	RB	denotes	particularly
T1890	1004-1013	JJ	denotes	important
T1891	1014-1017	IN	denotes	for
T1892	1018-1021	DT	denotes	the
T1893	1022-1032	NN	denotes	initiation
T1894	1033-1036	CC	denotes	and
T1895	1037-1047	NN	denotes	regulation
T1896	1048-1050	IN	denotes	of
T1897	1051-1055	NN	denotes	CD40
T1898	1056-1065	NN	denotes	signaling
T1899	1066-1067	-LRB-	denotes	[
T1900	1067-1068	CD	denotes	4
T1901	1068-1069	-RRB-	denotes	]
T1902	1071-1076	DT	denotes	These
T1903	1077-1085	NN	denotes	proteins
T1904	1086-1094	VB	denotes	function
T1905	1095-1097	IN	denotes	in
T1906	1098-1102	NN	denotes	part
T1907	1103-1105	IN	denotes	as
T1908	1106-1113	NN	denotes	adaptor
T1909	1114-1123	NN	denotes	molecules
T1910	1123-1124	-COMMA-	denotes	,
T1911	1125-1132	VB	denotes	binding
T1912	1133-1135	TO	denotes	to
T1913	1136-1139	DT	denotes	the
T1914	1140-1151	JJ	denotes	cytoplasmic
T1915	1152-1156	NN	denotes	tail
T1916	1157-1159	IN	denotes	of
T1917	1160-1164	NN	denotes	CD40
T1918	1165-1168	CC	denotes	and
T1919	1169-1179	VB	denotes	recruiting
T1920	1180-1185	JJ	denotes	other
T1921	1186-1194	NN	denotes	proteins
T1922	1195-1197	TO	denotes	to
T1923	1198-1201	DT	denotes	the
T1924	1202-1221	JJ	denotes	receptor-associated
T1925	1222-1229	NN	denotes	complex
T1926	1231-1235	DT	denotes	Some
T1927	1236-1238	IN	denotes	of
T1928	1239-1242	DT	denotes	the
T1929	1243-1248	NN	denotes	TRAFs
T1930	1249-1253	RB	denotes	also
T1931	1254-1262	VB	denotes	function
T1932	1263-1265	IN	denotes	as
T1933	1266-1268	NN	denotes	E3
T1934	1269-1278	NN	denotes	ubiquitin
T1935	1279-1286	NN	denotes	ligases
T1936	1286-1287	-COMMA-	denotes	,
T1937	1288-1291	CC	denotes	and
T1938	1292-1296	DT	denotes	this
T1939	1297-1306	JJ	denotes	enzymatic
T1940	1307-1315	NN	denotes	activity
T1941	1316-1319	MD	denotes	may
T1942	1320-1330	VB	denotes	contribute
T1943	1331-1333	TO	denotes	to
T1944	1334-1340	NN	denotes	signal
T1945	1341-1352	NN	denotes	propagation
T1946	1353-1356	CC	denotes	and
T1947	1357-1367	NN	denotes	regulation
T1948	1369-1374	IN	denotes	Among
T1949	1375-1378	DT	denotes	the
T1950	1379-1387	JJ	denotes	multiple
T1951	1388-1393	NN	denotes	TRAFs
T1952	1394-1398	WDT	denotes	that
T1953	1399-1408	VB	denotes	associate
T1954	1409-1413	IN	denotes	with
T1955	1414-1418	NN	denotes	CD40
T1956	1418-1419	-COMMA-	denotes	,
T1957	1420-1425	NN	denotes	TRAF3
T1958	1426-1429	MD	denotes	can
T1959	1430-1438	VB	denotes	function
T1960	1439-1441	IN	denotes	as
T1961	1442-1443	DT	denotes	a
T1962	1444-1452	JJ	denotes	negative
T1963	1453-1462	NN	denotes	regulator
T1964	1463-1465	IN	denotes	of
T1965	1466-1475	NN	denotes	signaling
T1966	1475-1476	-COMMA-	denotes	,
T1967	1477-1482	IN	denotes	while
T1968	1483-1488	NN	denotes	TRAF2
T1969	1489-1492	CC	denotes	and
T1970	1493-1498	NN	denotes	TRAF6
T1971	1499-1506	VB	denotes	promote
T1972	1507-1510	DT	denotes	the
T1973	1511-1521	NN	denotes	activation
T1974	1522-1524	IN	denotes	of
T1975	1525-1535	JJ	denotes	downstream
T1976	1536-1545	NN	denotes	signaling
T1977	1546-1554	NN	denotes	pathways
T1978	1555-1556	-LRB-	denotes	[
T1979	1556-1557	CD	denotes	4
T1980	1557-1558	-RRB-	denotes	]
T1981	1560-1562	PRP	denotes	We
T1982	1563-1571	RB	denotes	recently
T1983	1572-1584	VB	denotes	demonstrated
T1984	1585-1589	IN	denotes	that
T1985	1590-1597	NN	denotes	HOIL-1L
T1986	1598-1609	VB	denotes	interacting
T1987	1610-1617	NN	denotes	protein
T1988	1618-1619	-LRB-	denotes	(
T1989	1619-1623	NN	denotes	HOIP
T1990	1623-1624	-RRB-	denotes	)
T1991	1624-1625	-COMMA-	denotes	,
T1992	1626-1627	DT	denotes	a
T1993	1628-1637	NN	denotes	ubiquitin
T1994	1638-1644	NN	denotes	ligase
T1995	1645-1649	WDT	denotes	that
T1996	1650-1653	MD	denotes	can
T1997	1654-1662	VB	denotes	catalyze
T1998	1663-1666	DT	denotes	the
T1999	1667-1675	NN	denotes	assembly
T2000	1676-1678	IN	denotes	of
T2001	1679-1685	JJ	denotes	linear
T2002	1686-1699	NN	denotes	polyubiquitin
T2003	1700-1706	NN	denotes	chains
T2004	1707-1708	-LRB-	denotes	[
T2005	1708-1709	CD	denotes	5
T2006	1709-1710	-RRB-	denotes	]
T2007	1710-1711	-COMMA-	denotes	,
T2008	1712-1714	VB	denotes	is
T2009	1715-1724	VB	denotes	recruited
T2010	1725-1727	TO	denotes	to
T2011	1728-1732	NN	denotes	CD40
T2012	1733-1735	IN	denotes	in
T2013	1736-1737	DT	denotes	a
T2014	1738-1753	JJ	denotes	TRAF2-dependent
T2015	1754-1760	NN	denotes	manner
T2016	1761-1770	VB	denotes	following
T2017	1771-1781	NN	denotes	engagement
T2018	1782-1784	IN	denotes	of
T2019	1785-1789	NN	denotes	CD40
T2020	1790-1792	IN	denotes	by
T2021	1793-1802	JJ	denotes	agonistic
T2022	1803-1811	NN	denotes	antibody
T2023	1812-1813	-LRB-	denotes	[
T2024	1813-1814	CD	denotes	6
T2025	1814-1815	-RRB-	denotes	]
T2026	1817-1822	DT	denotes	These
T2027	1823-1826	CC	denotes	and
T2028	1827-1832	JJ	denotes	other
T2029	1833-1841	NN	denotes	findings
T2030	1842-1845	VB	denotes	led
T2031	1846-1848	PRP	denotes	us
T2032	1849-1851	TO	denotes	to
T2033	1852-1863	VB	denotes	hypothesize
T2034	1864-1868	IN	denotes	that
T2035	1869-1873	NN	denotes	HOIP
T2036	1874-1883	VB	denotes	functions
T2037	1884-1894	RB	denotes	downstream
T2038	1895-1897	IN	denotes	of
T2039	1898-1903	NN	denotes	TRAF2
T2040	1904-1906	IN	denotes	in
T2041	1907-1910	DT	denotes	the
T2042	1911-1915	NN	denotes	CD40
T2043	1916-1925	NN	denotes	signaling
T2044	1926-1933	NN	denotes	pathway
T2045	1934-1937	CC	denotes	and
T2046	1938-1942	IN	denotes	that
T2047	1943-1947	NN	denotes	HOIP
T2048	1948-1950	VB	denotes	is
T2049	1951-1960	JJ	denotes	necessary
T2050	1961-1964	IN	denotes	for
T2051	1965-1968	DT	denotes	the
T2052	1969-1979	NN	denotes	activation
T2053	1980-1982	IN	denotes	of
T2054	1983-1988	NN	denotes	NF-κB
T2055	1989-1992	CC	denotes	and
T2056	1993-2001	RB	denotes	possibly
T2057	2002-2007	JJ	denotes	other
T2058	2008-2017	VB	denotes	signaling
T2059	2018-2027	NN	denotes	molecules
T2060	2029-2031	TO	denotes	To
T2061	2032-2036	VB	denotes	test
T2062	2037-2041	DT	denotes	this
T2063	2042-2052	NN	denotes	hypothesis
T2064	2052-2053	-COMMA-	denotes	,
T2065	2054-2056	PRP	denotes	we
T2066	2057-2065	VB	denotes	employed
T2067	2066-2073	JJ	denotes	somatic
T2068	2074-2078	NN	denotes	cell
T2069	2079-2083	NN	denotes	gene
T2070	2084-2093	VB	denotes	targeting
T2071	2094-2096	TO	denotes	to
T2072	2097-2103	VB	denotes	ablate
T2073	2104-2114	NN	denotes	expression
T2074	2115-2117	IN	denotes	of
T2075	2118-2122	NN	denotes	HOIP
T2076	2123-2125	IN	denotes	in
T2077	2126-2127	DT	denotes	a
T2078	2128-2133	NN	denotes	mouse
T2079	2134-2135	NN	denotes	B
T2080	2136-2140	NN	denotes	cell
T2081	2141-2145	NN	denotes	line
T2082	2146-2150	WDT	denotes	that
T2083	2151-2154	VB	denotes	has
T2084	2155-2161	VB	denotes	proven
T2085	2162-2164	TO	denotes	to
T2086	2165-2167	VB	denotes	be
T2087	2168-2169	DT	denotes	a
T2088	2170-2176	JJ	denotes	useful
T2089	2177-2182	NN	denotes	model
T2090	2183-2186	IN	denotes	for
T2091	2187-2188	NN	denotes	B
T2092	2189-2193	NN	denotes	cell
T2093	2194-2198	NN	denotes	CD40
T2094	2199-2208	NN	denotes	signaling
T2095	2209-2210	-LRB-	denotes	[
T2096	2210-2211	CD	denotes	7
T2097	2211-2212	-RRB-	denotes	]
T2098	2212-2213	-COMMA-	denotes	,
T2099	2214-2215	-LRB-	denotes	[
T2100	2215-2216	CD	denotes	8
T2101	2216-2217	-RRB-	denotes	]
T2102	2217-2218	-COMMA-	denotes	,
T2103	2219-2220	-LRB-	denotes	[
T2104	2220-2221	CD	denotes	9
T2105	2221-2222	-RRB-	denotes	]
T2106	2224-2226	PRP	denotes	We
T2107	2227-2232	VB	denotes	found
T2108	2233-2237	IN	denotes	that
T2109	2238-2241	DT	denotes	the
T2110	2242-2254	JJ	denotes	CD40-induced
T2111	2255-2267	NN	denotes	upregulation
T2112	2268-2270	IN	denotes	of
T2113	2271-2275	NN	denotes	CD80
T2114	2276-2277	-LRB-	denotes	(
T2115	2277-2278	DT	denotes	a
T2116	2279-2292	JJ	denotes	costimulatory
T2117	2293-2301	NN	denotes	molecule
T2118	2302-2305	IN	denotes	for
T2119	2306-2307	NN	denotes	T
T2120	2308-2313	NN	denotes	cells
T2121	2313-2314	-RRB-	denotes	)
T2122	2315-2318	VB	denotes	was
T2123	2319-2328	JJ	denotes	defective
T2124	2329-2331	IN	denotes	in
T2125	2332-2346	JJ	denotes	HOIP-deficient
T2126	2347-2352	NN	denotes	cells
T2127	2354-2363	RB	denotes	Similarly
T2128	2363-2364	-COMMA-	denotes	,
T2129	2365-2368	DT	denotes	the
T2130	2369-2373	NN	denotes	CD40
T2131	2374-2377	CC	denotes	and
T2132	2378-2382	NN	denotes	IL-4
T2133	2383-2389	JJ	denotes	driven
T2134	2390-2400	NN	denotes	production
T2135	2401-2403	IN	denotes	of
T2136	2404-2412	NN	denotes	germline
T2137	2413-2424	NN	denotes	transcripts
T2138	2425-2429	IN	denotes	from
T2139	2430-2433	DT	denotes	the
T2140	2434-2448	NN	denotes	immunoglobulin
T2141	2449-2456	NN	denotes	epsilon
T2142	2457-2462	JJ	denotes	heavy
T2143	2463-2468	NN	denotes	chain
T2144	2469-2474	NN	denotes	locus
T2145	2474-2475	-COMMA-	denotes	,
T2146	2476-2478	DT	denotes	an
T2147	2479-2484	NN	denotes	event
T2148	2485-2489	WDT	denotes	that
T2149	2490-2498	VB	denotes	precedes
T2150	2499-2513	NN	denotes	immunoglobulin
T2151	2514-2518	NN	denotes	gene
T2152	2519-2532	NN	denotes	rearrangement
T2153	2533-2536	CC	denotes	and
T2154	2537-2544	NN	denotes	isotype
T2155	2545-2554	NN	denotes	switching
T2156	2554-2555	-COMMA-	denotes	,
T2157	2556-2559	VB	denotes	was
T2158	2560-2569	JJ	denotes	defective
T2159	2570-2572	IN	denotes	in
T2160	2573-2576	DT	denotes	the
T2161	2577-2584	NN	denotes	absence
T2162	2585-2587	IN	denotes	of
T2163	2588-2592	NN	denotes	HOIP
T2164	2594-2596	PRP	denotes	We
T2165	2597-2601	RB	denotes	also
T2166	2602-2607	VB	denotes	found
T2167	2608-2612	IN	denotes	that
T2168	2613-2616	DT	denotes	the
T2169	2617-2630	JJ	denotes	CD40-mediated
T2170	2631-2641	NN	denotes	activation
T2171	2642-2644	IN	denotes	of
T2172	2645-2650	NN	denotes	NF-κB
T2173	2651-2654	CC	denotes	and
T2174	2655-2658	DT	denotes	the
T2175	2659-2675	JJ	denotes	stress-activated
T2176	2676-2683	NN	denotes	protein
T2177	2684-2690	NN	denotes	kinase
T2178	2691-2696	NN	denotes	c-Jun
T2179	2697-2703	NN	denotes	kinase
T2180	2704-2705	-LRB-	denotes	(
T2181	2705-2708	NN	denotes	JNK
T2182	2708-2709	-RRB-	denotes	)
T2183	2710-2713	VB	denotes	was
T2184	2714-2723	JJ	denotes	defective
T2185	2724-2726	IN	denotes	in
T2186	2727-2741	JJ	denotes	HOIP-deficient
T2187	2742-2747	NN	denotes	cells
T2188	2749-2759	JJ	denotes	Consistent
T2189	2760-2764	IN	denotes	with
T2190	2765-2773	JJ	denotes	impaired
T2191	2774-2779	NN	denotes	NF-κB
T2192	2780-2790	NN	denotes	activation
T2193	2790-2791	-COMMA-	denotes	,
T2194	2792-2803	NN	denotes	association
T2195	2804-2806	IN	denotes	of
T2196	2807-2810	DT	denotes	the
T2197	2811-2814	NN	denotes	IκB
T2198	2815-2821	NN	denotes	kinase
T2199	2822-2823	-LRB-	denotes	(
T2200	2823-2826	NN	denotes	IKK
T2201	2826-2827	-RRB-	denotes	)
T2202	2828-2835	NN	denotes	complex
T2203	2836-2840	IN	denotes	with
T2204	2841-2845	NN	denotes	CD40
T2205	2846-2849	VB	denotes	was
T2206	2850-2862	JJ	denotes	undetectable
T2207	2863-2865	IN	denotes	in
T2208	2866-2880	JJ	denotes	HOIP-deficient
T2209	2881-2886	NN	denotes	cells
T2210	2888-2896	RB	denotes	Together
T2211	2896-2897	-COMMA-	denotes	,
T2212	2898-2901	PRP-DOLLAR-	denotes	our
T2213	2902-2909	NN	denotes	results
T2214	2910-2918	VB	denotes	indicate
T2215	2919-2923	IN	denotes	that
T2216	2924-2928	NN	denotes	HOIP
T2217	2929-2934	VB	denotes	plays
T2218	2935-2936	DT	denotes	a
T2219	2937-2945	JJ	denotes	critical
T2220	2946-2950	NN	denotes	role
T2221	2951-2953	IN	denotes	in
T2222	2954-2957	DT	denotes	the
T2223	2958-2968	NN	denotes	activation
T2224	2969-2971	IN	denotes	of
T2225	2972-2981	NN	denotes	signaling
T2226	2982-2990	NN	denotes	pathways
T2227	2991-2995	WDT	denotes	that
T2228	2996-3004	VB	denotes	regulate
T2229	3005-3013	JJ	denotes	cellular
T2230	3014-3023	NN	denotes	responses
T2231	3024-3026	TO	denotes	to
T2232	3027-3031	NN	denotes	CD40
T2233	3032-3042	NN	denotes	engagement
T7475	1943-1947	NN	denotes	HOIP
T7476	1948-1950	VB	denotes	is
T7477	1951-1960	JJ	denotes	necessary
T7478	1961-1964	IN	denotes	for
T7479	2792-2803	NN	denotes	association
T7480	2804-2806	IN	denotes	of
T7481	2807-2810	DT	denotes	the
R1343	T1726	T1725	arg1Of	signaling,CD40
R1344	T1726	T1727	arg1Of	signaling,in
R1345	T1726	T1742	arg1Of	signaling,is
R1346	T1726	T1743	arg1Of	signaling,critical
R1347	T1730	T1727	arg2Of	cells,in
R1348	T1730	T1728	arg1Of	cells,professional
R1349	T1730	T1729	arg1Of	cells,antigen-presenting
R1350	T1730	T1731	arg1Of	cells,","
R1351	T1730	T1732	arg1Of	cells,including
R1352	T1734	T1733	arg1Of	cells,B
R1353	T1734	T1735	arg1Of	cells,","
R1354	T1735	T1738	arg1Of	",",and
R1355	T1736	T1735	arg2Of	macrophages,","
R1356	T1738	T1732	arg2Of	and,including
R1357	T1738	T1737	arg1Of	and,","
R1358	T1740	T1738	arg2Of	cells,and
R1359	T1740	T1739	arg1Of	cells,dendritic
R1360	T1742	T1741	arg1Of	is,","
R1361	T1742	T1757	arg1Of	is,","
R1362	T1742	T1758	arg1Of	is,[
R1363	T1742	T1761	arg1Of	is,","
R1364	T1742	T1762	arg1Of	is,[
R1365	T1743	T1742	arg2Of	critical,is
R1366	T1743	T1744	arg1Of	critical,for
R1367	T1747	T1744	arg2Of	activation,for
R1368	T1747	T1745	arg1Of	activation,the
R1369	T1747	T1746	arg1Of	activation,efficient
R1370	T1747	T1748	arg1Of	activation,of
R1371	T1749	T1750	arg1Of	humoral,and
R1372	T1751	T1750	arg2Of	cell-mediated,and
R1373	T1753	T1748	arg2Of	responses,of
R1374	T1753	T1749	arg1Of	responses,humoral
R1375	T1753	T1751	arg1Of	responses,cell-mediated
R1376	T1753	T1752	arg1Of	responses,immune
R1377	T1753	T1754	arg1Of	responses,[
R1378	T1755	T1754	arg2Of	1,[
R1379	T1756	T1754	arg3Of	],[
R1380	T1759	T1758	arg2Of	2,[
R1381	T1760	T1758	arg3Of	],[
R1382	T1763	T1762	arg2Of	3,[
R1383	T1764	T1762	arg3Of	],[
R1384	T1766	T1765	arg1Of	signaling,CD40
R1385	T1766	T1767	arg1Of	signaling,is
R1386	T1766	T1768	arg2Of	signaling,activated
R1387	T1768	T1767	arg2Of	activated,is
R1388	T1768	T1769	arg1Of	activated,in
R1389	T1768	T1774	arg1Of	activated,","
R1390	T1768	T1775	arg1Of	activated,as
R1391	T1773	T1769	arg2Of	manner,in
R1392	T1773	T1770	arg1Of	manner,a
R1393	T1773	T1771	arg1Of	manner,T
R1394	T1773	T1772	arg1Of	manner,cell-dependent
R1395	T1777	T1776	arg1Of	ligand,the
R1396	T1777	T1778	arg1Of	ligand,for
R1397	T1777	T1783	arg1Of	ligand,is
R1398	T1777	T1784	arg2Of	ligand,expressed
R1399	T1779	T1778	arg2Of	CD40,for
R1400	T1779	T1780	arg1Of	CD40,","
R1401	T1781	T1780	arg2Of	CD154,","
R1402	T1784	T1775	arg2Of	expressed,as
R1403	T1784	T1782	arg1Of	expressed,","
R1404	T1784	T1783	arg2Of	expressed,is
R1405	T1784	T1785	arg1Of	expressed,primarily
R1406	T1789	T1784	arg1Of	cells,expressed
R1407	T1789	T1786	arg2Of	cells,by
R1408	T1789	T1787	arg2Of	cells,activated
R1409	T1789	T1788	arg1Of	cells,T
R1410	T1791	T1790	arg1Of	engagement,CD40
R1411	T1791	T1792	arg1Of	engagement,leads
R1412	T1792	T1793	arg1Of	leads,to
R1413	T1795	T1793	arg2Of	activation,to
R1414	T1795	T1794	arg1Of	activation,the
R1415	T1795	T1796	arg1Of	activation,of
R1416	T1799	T1796	arg2Of	molecules,of
R1417	T1799	T1797	arg1Of	molecules,various
R1418	T1799	T1798	arg1Of	molecules,signaling
R1419	T1799	T1800	arg1Of	molecules,","
R1420	T1799	T1801	arg1Of	molecules,including
R1421	T1804	T1802	arg1Of	kinases,stress-activated
R1422	T1804	T1803	arg1Of	kinases,protein
R1423	T1804	T1805	arg1Of	kinases,and
R1424	T1805	T1801	arg2Of	and,including
R1425	T1809	T1805	arg2Of	NF-κB,and
R1426	T1809	T1806	arg1Of	NF-κB,the
R1427	T1809	T1807	arg1Of	NF-κB,transcription
R1428	T1809	T1808	arg1Of	NF-κB,factor
R1429	T1809	T1810	arg1Of	NF-κB,","
R1430	T1809	T1811	arg1Of	NF-κB,which
R1431	T1809	T1812	arg1Of	NF-κB,upregulate
R1432	T1814	T1812	arg2Of	expression,upregulate
R1433	T1814	T1813	arg1Of	expression,the
R1434	T1814	T1815	arg1Of	expression,of
R1435	T1816	T1817	arg1Of	cytokines,and
R1436	T1817	T1815	arg2Of	and,of
R1437	T1817	T1820	arg1Of	and,that
R1438	T1817	T1821	arg1Of	and,promote
R1439	T1819	T1817	arg2Of	factors,and
R1440	T1819	T1818	arg1Of	factors,other
R1441	T1823	T1821	arg2Of	responses,promote
R1442	T1823	T1822	arg1Of	responses,immune
R1443	T1825	T1824	arg1Of	mechanism,The
R1444	T1825	T1826	arg2Of	mechanism,by
R1445	T1825	T1827	arg1Of	mechanism,which
R1446	T1825	T1833	arg1Of	mechanism,has
R1447	T1825	T1835	arg1Of	mechanism,been
R1448	T1825	T1837	arg2Of	mechanism,defined
R1449	T1828	T1829	arg1Of	CD40,induces
R1450	T1829	T1826	arg1Of	induces,by
R1451	T1832	T1829	arg2Of	pathways,induces
R1452	T1832	T1830	arg1Of	pathways,these
R1453	T1832	T1831	arg1Of	pathways,signaling
R1454	T1837	T1833	arg2Of	defined,has
R1455	T1837	T1834	arg1Of	defined,not
R1456	T1837	T1835	arg2Of	defined,been
R1457	T1837	T1836	arg1Of	defined,completely
R1458	T1840	T1838	arg1Of	domain,The
R1459	T1840	T1839	arg1Of	domain,cytoplasmic
R1460	T1840	T1841	arg1Of	domain,of
R1461	T1840	T1843	arg1Of	domain,does
R1462	T1840	T1845	arg1Of	domain,appear
R1463	T1840	T1847	arg1Of	domain,have
R1464	T1840	T1853	arg1Of	domain,is
R1465	T1840	T1854	arg1Of	domain,able
R1466	T1840	T1856	arg1Of	domain,mediate
R1467	T1842	T1841	arg2Of	CD40,of
R1468	T1845	T1843	arg2Of	appear,does
R1469	T1845	T1844	arg1Of	appear,not
R1470	T1845	T1852	arg1Of	appear,but
R1471	T1847	T1845	arg2Of	have,appear
R1472	T1847	T1846	arg1Of	have,to
R1473	T1850	T1847	arg2Of	activity,have
R1474	T1850	T1848	arg1Of	activity,intrinsic
R1475	T1850	T1849	arg1Of	activity,enzymatic
R1476	T1852	T1851	arg1Of	but,","
R1477	T1853	T1852	arg2Of	is,but
R1478	T1854	T1853	arg2Of	able,is
R1479	T1856	T1854	arg2Of	mediate,able
R1480	T1856	T1855	arg1Of	mediate,to
R1481	T1856	T1858	arg1Of	mediate,through
R1482	T1857	T1856	arg2Of	signaling,mediate
R1483	T1860	T1858	arg2Of	recruitment,through
R1484	T1860	T1859	arg1Of	recruitment,the
R1485	T1860	T1861	arg1Of	recruitment,of
R1486	T1864	T1861	arg2Of	proteins,of
R1487	T1864	T1862	arg1Of	proteins,several
R1488	T1864	T1863	arg1Of	proteins,intracellular
R1489	T1865	T1866	arg1Of	Members,of
R1490	T1865	T1875	arg1Of	Members,","
R1491	T1865	T1876	arg1Of	Members,including
R1492	T1865	T1886	arg1Of	Members,appear
R1493	T1865	T1888	arg1Of	Members,be
R1494	T1900	T1899	arg2Of	4,[
R1495	T1865	T1890	arg1Of	Members,important
R1496	T1872	T1871	arg2Of	TRAF,(
R1497	T1901	T1899	arg3Of	],[
R1498	T1903	T1902	arg1Of	proteins,These
R1499	T1903	T1904	arg1Of	proteins,function
R1500	T1903	T1911	arg1Of	proteins,binding
R1501	T1903	T1919	arg1Of	proteins,recruiting
R1502	T1904	T1905	arg1Of	function,in
R1503	T1904	T1907	arg1Of	function,as
R1504	T1904	T1910	arg1Of	function,","
R1505	T1904	T1911	modOf	function,binding
R1506	T1904	T1919	modOf	function,recruiting
R1507	T1906	T1905	arg2Of	part,in
R1508	T1909	T1907	arg2Of	molecules,as
R1509	T1909	T1908	arg1Of	molecules,adaptor
R1510	T1911	T1912	arg1Of	binding,to
R1511	T1911	T1918	arg1Of	binding,and
R1512	T1873	T1871	arg3Of	),(
R1513	T1874	T1866	arg2Of	family,of
R1514	T1915	T1912	arg2Of	tail,to
R1515	T1915	T1913	arg1Of	tail,the
R1516	T1915	T1914	arg1Of	tail,cytoplasmic
R1517	T1915	T1916	arg1Of	tail,of
R1518	T1917	T1916	arg2Of	CD40,of
R1519	T1919	T1918	arg2Of	recruiting,and
R1520	T1874	T1867	arg1Of	family,the
R1521	T1921	T1919	arg2Of	proteins,recruiting
R1522	T1921	T1920	arg1Of	proteins,other
R1523	T1921	T1922	arg1Of	proteins,to
R1524	T1874	T1868	arg1Of	family,TNF
R1525	T1874	T1869	arg1Of	family,receptor-associated
R1526	T1874	T1870	arg1Of	family,factor
R1527	T1925	T1922	arg2Of	complex,to
R1528	T1925	T1923	arg1Of	complex,the
R1529	T1925	T1924	arg1Of	complex,receptor-associated
R1530	T1874	T1871	arg1Of	family,(
R1531	T1877	T1878	arg1Of	TRAF1,","
R1532	T1926	T1927	arg1Of	Some,of
R1533	T1926	T1931	arg1Of	Some,function
R1534	T1929	T1927	arg2Of	TRAFs,of
R1535	T1929	T1928	arg1Of	TRAFs,the
R1536	T1931	T1930	arg1Of	function,also
R1537	T1931	T1932	arg1Of	function,as
R1538	T1931	T1937	arg1Of	function,and
R1539	T1878	T1880	arg1Of	",",","
R1540	T1935	T1932	arg2Of	ligases,as
R1541	T1935	T1933	arg1Of	ligases,E3
R1542	T1935	T1934	arg1Of	ligases,ubiquitin
R1543	T1937	T1936	arg1Of	and,","
R1544	T1879	T1878	arg2Of	TRAF2,","
R1545	T1880	T1883	arg1Of	",",and
R1546	T1881	T1880	arg2Of	TRAF3,","
R1547	T1940	T1938	arg1Of	activity,this
R1548	T1940	T1939	arg1Of	activity,enzymatic
R1549	T1940	T1941	arg1Of	activity,may
R1550	T1940	T1942	arg1Of	activity,contribute
R1551	T1883	T1876	arg2Of	and,including
R1552	T1942	T1937	arg2Of	contribute,and
R1553	T1942	T1941	arg2Of	contribute,may
R1554	T1942	T1943	arg1Of	contribute,to
R1555	T1945	T1946	arg1Of	propagation,and
R1556	T1883	T1882	arg1Of	and,","
R1557	T1946	T1943	arg2Of	and,to
R1558	T1946	T1944	arg1Of	and,signal
R1559	T1947	T1946	arg2Of	regulation,and
R1560	T1884	T1883	arg2Of	TRAF6,and
R1561	T1886	T1885	arg1Of	appear,","
R1562	T1951	T1948	arg2Of	TRAFs,Among
R1563	T1951	T1949	arg1Of	TRAFs,the
R1564	T1951	T1950	arg1Of	TRAFs,multiple
R1565	T1951	T1952	arg1Of	TRAFs,that
R1566	T1951	T1953	arg1Of	TRAFs,associate
R1567	T1953	T1954	arg1Of	associate,with
R1568	T1955	T1954	arg2Of	CD40,with
R1569	T1957	T1958	arg1Of	TRAF3,can
R1570	T1957	T1959	arg1Of	TRAF3,function
R1571	T1886	T1899	arg1Of	appear,[
R1572	T1959	T1948	arg1Of	function,Among
R1573	T1959	T1956	arg1Of	function,","
R1574	T1959	T1958	arg2Of	function,can
R1575	T1959	T1960	arg1Of	function,as
R1576	T1959	T1966	arg1Of	function,","
R1577	T1959	T1967	arg1Of	function,while
R1578	T1888	T1886	arg2Of	be,appear
R1579	T1963	T1960	arg2Of	regulator,as
R1580	T1963	T1961	arg1Of	regulator,a
R1581	T1963	T1962	arg1Of	regulator,negative
R1582	T1963	T1964	arg1Of	regulator,of
R1583	T1965	T1964	arg2Of	signaling,of
R1584	T1888	T1887	arg1Of	be,to
R1585	T1890	T1888	arg2Of	important,be
R1586	T1968	T1969	arg1Of	TRAF2,and
R1587	T1969	T1971	arg1Of	and,promote
R1588	T1890	T1889	arg1Of	important,particularly
R1589	T1970	T1969	arg2Of	TRAF6,and
R1590	T1971	T1967	arg2Of	promote,while
R1591	T1890	T1891	arg1Of	important,for
R1592	T1893	T1894	arg1Of	initiation,and
R1593	T1973	T1971	arg2Of	activation,promote
R1594	T1973	T1972	arg1Of	activation,the
R1595	T1973	T1974	arg1Of	activation,of
R1596	T1977	T1974	arg2Of	pathways,of
R1597	T1977	T1975	arg1Of	pathways,downstream
R1598	T1977	T1976	arg1Of	pathways,signaling
R1599	T1977	T1978	arg1Of	pathways,[
R1600	T1894	T1891	arg2Of	and,for
R1601	T1979	T1978	arg2Of	4,[
R1602	T1980	T1978	arg3Of	],[
R1603	T1981	T1983	arg1Of	We,demonstrated
R1604	T1894	T1892	arg1Of	and,the
R1605	T1894	T1896	arg1Of	and,of
R1606	T1983	T1982	arg1Of	demonstrated,recently
R1607	T1895	T1894	arg2Of	regulation,and
R1608	T1898	T1896	arg2Of	signaling,of
R1609	T1987	T1985	arg1Of	protein,HOIL-1L
R1610	T1987	T1986	arg1Of	protein,interacting
R1611	T1987	T1988	arg1Of	protein,(
R1612	T1987	T1991	arg1Of	protein,","
R1613	T1987	T2008	arg1Of	protein,is
R1614	T1987	T2009	arg2Of	protein,recruited
R1615	T1989	T1988	arg2Of	HOIP,(
R1616	T1990	T1988	arg3Of	),(
R1617	T1994	T1991	arg2Of	ligase,","
R1618	T1994	T1992	arg1Of	ligase,a
R1619	T1994	T1993	arg1Of	ligase,ubiquitin
R1620	T1994	T1995	arg1Of	ligase,that
R1621	T1994	T1996	arg1Of	ligase,can
R1622	T1994	T1997	arg1Of	ligase,catalyze
R1623	T1898	T1897	arg1Of	signaling,CD40
R1624	T2094	T2090	arg2Of	signaling,for
R1625	T2094	T2091	arg1Of	signaling,B
R1626	T1997	T1996	arg2Of	catalyze,can
R1627	T2094	T2092	arg1Of	signaling,cell
R1628	T2094	T2093	arg1Of	signaling,CD40
R1629	T1999	T1997	arg2Of	assembly,catalyze
R1630	T2094	T2095	arg1Of	signaling,[
R1631	T1999	T1998	arg1Of	assembly,the
R1632	T1999	T2000	arg1Of	assembly,of
R1633	T2096	T2095	arg2Of	7,[
R1634	T2003	T2000	arg2Of	chains,of
R1635	T2003	T2001	arg1Of	chains,linear
R1636	T2003	T2002	arg1Of	chains,polyubiquitin
R1637	T2003	T2004	arg1Of	chains,[
R1638	T2005	T2004	arg2Of	5,[
R1639	T2097	T2095	arg3Of	],[
R1640	T2006	T2004	arg3Of	],[
R1641	T2100	T2070	arg2Of	8,targeting
R1642	T2009	T1983	arg2Of	recruited,demonstrated
R1643	T2009	T1984	arg1Of	recruited,that
R1644	T2009	T2007	arg1Of	recruited,","
R1645	T2009	T2008	arg2Of	recruited,is
R1646	T2009	T2010	arg1Of	recruited,to
R1647	T2009	T2012	arg1Of	recruited,in
R1648	T2009	T2016	arg1Of	recruited,following
R1649	T2011	T2010	arg2Of	CD40,to
R1650	T2100	T2099	arg2Of	8,[
R1651	T2101	T2099	arg3Of	],[
R1652	T2015	T2012	arg2Of	manner,in
R1653	T2015	T2013	arg1Of	manner,a
R1654	T2015	T2014	arg1Of	manner,TRAF2-dependent
R1655	T2017	T2016	arg2Of	engagement,following
R1656	T2017	T2018	arg1Of	engagement,of
R1657	T2017	T2020	arg1Of	engagement,by
R1658	T2017	T2023	arg1Of	engagement,[
R1659	T2104	T2103	arg2Of	9,[
R1660	T2019	T2018	arg2Of	CD40,of
R1661	T2022	T2020	arg2Of	antibody,by
R1662	T2022	T2021	arg1Of	antibody,agonistic
R1663	T2105	T2103	arg3Of	],[
R1664	T2024	T2023	arg2Of	6,[
R1665	T2025	T2023	arg3Of	],[
R1666	T2029	T2026	arg1Of	findings,These
R1667	T2029	T2027	arg1Of	findings,and
R1668	T2029	T2028	arg1Of	findings,other
R1669	T2029	T2030	arg1Of	findings,led
R1670	T2106	T2107	arg1Of	We,found
R1671	T2031	T2030	arg2Of	us,led
R1672	T2031	T2033	arg1Of	us,hypothesize
R1673	T2033	T2030	arg3Of	hypothesize,led
R1674	T2033	T2032	arg1Of	hypothesize,to
R1675	T2111	T2109	arg1Of	upregulation,the
R1676	T2035	T2036	arg1Of	HOIP,functions
R1677	T2036	T2034	arg1Of	functions,that
R1678	T2036	T2037	arg1Of	functions,downstream
R1679	T2036	T2040	arg1Of	functions,in
R1680	T2036	T2045	arg1Of	functions,and
R1681	T2037	T2038	arg1Of	downstream,of
R1682	T2039	T2038	arg2Of	TRAF2,of
R1683	T2111	T2110	arg1Of	upregulation,CD40-induced
R1684	T2044	T2040	arg2Of	pathway,in
R1685	T2044	T2041	arg1Of	pathway,the
R1686	T2044	T2042	arg1Of	pathway,CD40
R1687	T2044	T2043	arg1Of	pathway,signaling
R1688	T2045	T2033	arg2Of	and,hypothesize
R1689	T2111	T2112	arg1Of	upregulation,of
R1690	T2046	T2045	arg2Of	that,and
R1691	T2111	T2122	arg1Of	upregulation,was
R1692	T2047	T2048	arg1Of	HOIP,is
R1693	T2047	T2049	arg1Of	HOIP,necessary
R1694	T2048	T2046	arg2Of	is,that
R1695	T2111	T2123	arg1Of	upregulation,defective
R1696	T2049	T2048	arg2Of	necessary,is
R1697	T2049	T2050	arg1Of	necessary,for
R1698	T2113	T2112	arg2Of	CD80,of
R1699	T2052	T2050	arg2Of	activation,for
R1700	T2052	T2051	arg1Of	activation,the
R1701	T2052	T2053	arg1Of	activation,of
R1702	T2054	T2055	arg1Of	NF-κB,and
R1703	T2055	T2053	arg2Of	and,of
R1704	T2113	T2114	arg1Of	CD80,(
R1705	T2117	T2114	arg2Of	molecule,(
R1706	T2059	T2055	arg2Of	molecules,and
R1707	T2059	T2056	arg1Of	molecules,possibly
R1708	T2059	T2057	arg1Of	molecules,other
R1709	T2059	T2058	arg1Of	molecules,signaling
R1710	T2061	T2060	arg1Of	test,To
R1711	T2063	T2061	arg2Of	hypothesis,test
R1712	T2063	T2062	arg1Of	hypothesis,this
R1713	T2117	T2115	arg1Of	molecule,a
R1714	T2065	T2061	arg1Of	we,test
R1715	T2065	T2066	arg1Of	we,employed
R1716	T2066	T2060	modOf	employed,To
R1717	T2066	T2064	arg1Of	employed,","
R1718	T2117	T2116	arg1Of	molecule,costimulatory
R1719	T2117	T2118	arg1Of	molecule,for
R1720	T2066	T2102	arg1Of	employed,","
R1721	T2066	T2103	arg1Of	employed,[
R1722	T2120	T2118	arg2Of	cells,for
R1723	T2069	T2066	arg2Of	gene,employed
R1724	T2069	T2067	arg1Of	gene,somatic
R1725	T2069	T2068	arg1Of	gene,cell
R1726	T2069	T2070	arg1Of	gene,targeting
R1727	T2070	T2071	modOf	targeting,to
R1728	T2070	T2098	arg1Of	targeting,","
R1729	T2072	T2071	arg1Of	ablate,to
R1730	T2073	T2072	arg2Of	expression,ablate
R1731	T2073	T2074	arg1Of	expression,of
R1732	T2073	T2076	arg1Of	expression,in
R1733	T2120	T2119	arg1Of	cells,T
R1734	T2121	T2114	arg3Of	),(
R1735	T2075	T2074	arg2Of	HOIP,of
R1736	T2122	T2107	arg2Of	was,found
R1737	T2122	T2108	arg1Of	was,that
R1738	T2122	T2124	arg1Of	was,in
R1739	T2081	T2076	arg2Of	line,in
R1740	T2081	T2077	arg1Of	line,a
R1741	T2081	T2078	arg1Of	line,mouse
R1742	T2081	T2079	arg1Of	line,B
R1743	T2123	T2122	arg2Of	defective,was
R1744	T2081	T2080	arg1Of	line,cell
R1745	T2081	T2082	arg1Of	line,that
R1746	T2081	T2083	arg1Of	line,has
R1747	T2081	T2084	arg1Of	line,proven
R1748	T2081	T2086	arg1Of	line,be
R1749	T2126	T2124	arg2Of	cells,in
R1750	T2126	T2125	arg1Of	cells,HOIP-deficient
R1751	T2084	T2083	arg2Of	proven,has
R1752	T2130	T2131	arg1Of	CD40,and
R1753	T2086	T2084	arg2Of	be,proven
R1754	T2086	T2085	arg1Of	be,to
R1755	T2089	T2086	arg2Of	model,be
R1756	T2089	T2087	arg1Of	model,a
R1757	T2089	T2088	arg1Of	model,useful
R1758	T2089	T2090	arg1Of	model,for
R1759	T2132	T2131	arg2Of	IL-4,and
R1760	T2134	T2129	arg1Of	production,the
R1761	T2134	T2130	arg1Of	production,CD40
R1762	T2134	T2132	arg1Of	production,IL-4
R1763	T2134	T2133	arg1Of	production,driven
R1764	T2192	T2189	arg2Of	activation,with
R1765	T2192	T2190	arg1Of	activation,impaired
R1766	T2192	T2191	arg1Of	activation,NF-κB
R1767	T2194	T2188	arg1Of	association,Consistent
R1768	T2194	T2195	arg1Of	association,of
R1769	T2194	T2203	arg1Of	association,with
R1770	T2194	T2205	arg1Of	association,was
R1771	T2194	T2206	arg1Of	association,undetectable
R1772	T2134	T2135	arg1Of	production,of
R1773	T2134	T2157	arg1Of	production,was
R1774	T2198	T2197	arg1Of	kinase,IκB
R1775	T2198	T2199	arg1Of	kinase,(
R1776	T2134	T2158	arg1Of	production,defective
R1777	T2200	T2199	arg2Of	IKK,(
R1778	T2137	T2135	arg2Of	transcripts,of
R1779	T2201	T2199	arg3Of	),(
R1780	T2202	T2195	arg2Of	complex,of
R1781	T2202	T2196	arg1Of	complex,the
R1782	T2202	T2198	arg1Of	complex,kinase
R1783	T2204	T2203	arg2Of	CD40,with
R1784	T2205	T2188	modOf	was,Consistent
R1785	T2205	T2193	arg1Of	was,","
R1786	T2205	T2207	arg1Of	was,in
R1787	T2206	T2205	arg2Of	undetectable,was
R1788	T2137	T2136	arg1Of	transcripts,germline
R1789	T2137	T2138	arg1Of	transcripts,from
R1790	T2209	T2207	arg2Of	cells,in
R1791	T2209	T2208	arg1Of	cells,HOIP-deficient
R1792	T2144	T2138	arg2Of	locus,from
R1793	T2213	T2212	arg1Of	results,our
R1794	T2213	T2214	arg1Of	results,indicate
R1795	T2214	T2210	arg1Of	indicate,Together
R1796	T2214	T2211	arg1Of	indicate,","
R1797	T2216	T2217	arg1Of	HOIP,plays
R1798	T2217	T2214	arg2Of	plays,indicate
R1799	T2217	T2215	arg1Of	plays,that
R1800	T2217	T2221	arg1Of	plays,in
R1801	T2220	T2217	arg2Of	role,plays
R1802	T2220	T2218	arg1Of	role,a
R1803	T2220	T2219	arg1Of	role,critical
R1804	T2144	T2139	arg1Of	locus,the
R1805	T2223	T2221	arg2Of	activation,in
R1806	T2223	T2222	arg1Of	activation,the
R1807	T2223	T2224	arg1Of	activation,of
R1808	T2144	T2140	arg1Of	locus,immunoglobulin
R1809	T2144	T2141	arg1Of	locus,epsilon
R1810	T2144	T2142	arg1Of	locus,heavy
R1811	T2226	T2224	arg2Of	pathways,of
R1812	T2226	T2225	arg1Of	pathways,signaling
R1813	T2226	T2227	arg1Of	pathways,that
R1814	T2226	T2228	arg1Of	pathways,regulate
R1815	T2144	T2143	arg1Of	locus,chain
R1816	T2144	T2145	arg1Of	locus,","
R1817	T2230	T2228	arg2Of	responses,regulate
R1818	T2230	T2229	arg1Of	responses,cellular
R1819	T2230	T2231	arg1Of	responses,to
R1820	T2147	T2145	arg2Of	event,","
R1821	T2233	T2231	arg2Of	engagement,to
R1822	T2233	T2232	arg1Of	engagement,CD40
R1823	T2147	T2146	arg1Of	event,an
R1824	T2147	T2148	arg1Of	event,that
R1825	T2147	T2149	arg1Of	event,precedes
R1826	T2152	T2150	arg1Of	rearrangement,immunoglobulin
R1827	T2152	T2151	arg1Of	rearrangement,gene
R1828	T2152	T2153	arg1Of	rearrangement,and
R1829	T2153	T2149	arg2Of	and,precedes
R1834	T2155	T2153	arg2Of	switching,and
R1835	T2155	T2154	arg1Of	switching,isotype
R1839	T2157	T2127	arg1Of	was,Similarly
R1841	T2157	T2128	arg1Of	was,","
R1842	T2157	T2156	arg1Of	was,","
R1843	T2157	T2159	arg1Of	was,in
R1844	T2158	T2157	arg2Of	defective,was
R1845	T2161	T2159	arg2Of	absence,in
R1846	T2161	T2160	arg1Of	absence,the
R1847	T2161	T2162	arg1Of	absence,of
R1848	T2163	T2162	arg2Of	HOIP,of
R1849	T2164	T2166	arg1Of	We,found
R1850	T2166	T2165	arg1Of	found,also
R1851	T2170	T2168	arg1Of	activation,the
R1852	T2170	T2169	arg1Of	activation,CD40-mediated
R1853	T2170	T2171	arg1Of	activation,of
R1854	T2170	T2173	arg1Of	activation,and
R1855	T2172	T2171	arg2Of	NF-κB,of
R1856	T2173	T2183	arg1Of	and,was
R1857	T2173	T2184	arg1Of	and,defective
R1858	T2179	T2173	arg2Of	kinase,and
R1859	T2179	T2174	arg1Of	kinase,the
R1860	T2179	T2175	arg1Of	kinase,stress-activated
R1861	T2179	T2176	arg1Of	kinase,protein
R1862	T2179	T2177	arg1Of	kinase,kinase
R1863	T2179	T2178	arg1Of	kinase,c-Jun
R1864	T2179	T2180	arg1Of	kinase,(
R1865	T2181	T2180	arg2Of	JNK,(
R1866	T2182	T2180	arg3Of	),(
R1867	T2183	T2166	arg2Of	was,found
R1868	T2183	T2167	arg1Of	was,that
R1869	T2183	T2185	arg1Of	was,in
R1870	T2184	T2183	arg2Of	defective,was
R1871	T2187	T2185	arg2Of	cells,in
R1872	T2187	T2186	arg1Of	cells,HOIP-deficient
R1873	T2188	T2189	arg1Of	Consistent,with
R5833	T7475	T7476	arg1Of	HOIP,is
R5834	T7475	T7477	arg1Of	HOIP,necessary
R5835	T7477	T7476	arg2Of	necessary,is
R5836	T7477	T7478	arg1Of	necessary,for
R5837	T7479	T7478	arg2Of	association,for
R5838	T7479	T7480	arg1Of	association,of

2_test

Id	Subject	Object	Predicate	Lexical cue
21829693-19426221-89653748	211-212	19426221	denotes	1
21829693-10647992-89653749	216-217	10647992	denotes	2
21829693-18499506-89653750	221-222	18499506	denotes	3
21829693-17633023-89653751	1067-1068	17633023	denotes	4
21829693-17633023-89653752	1556-1557	17633023	denotes	4
21829693-17006537-89653753	1708-1709	17006537	denotes	5
21829693-20614026-89653754	1813-1814	20614026	denotes	6
21829693-12958312-89653755	2210-2211	12958312	denotes	7
21829693-17878362-89653756	2215-2216	17878362	denotes	8
21829693-14981114-89653757	2220-2221	14981114	denotes	9
T47453	211-212	19426221	denotes	1
T32221	216-217	10647992	denotes	2
T20683	221-222	18499506	denotes	3
T36519	1067-1068	17633023	denotes	4
T85269	1556-1557	17633023	denotes	4
T1216	1708-1709	17006537	denotes	5
T18092	1813-1814	20614026	denotes	6
T40872	2210-2211	12958312	denotes	7
T96147	2215-2216	17878362	denotes	8
T94358	2220-2221	14981114	denotes	9

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T1199	13-17	CD	denotes	CD40
T1200	18-27	VBG	denotes	signaling
T1201	28-30	IN	denotes	in
T1202	31-43	JJ	denotes	professional
T1203	44-62	JJ	denotes	antigen-presenting
T1204	63-68	NNS	denotes	cells
T1205	68-69	,	denotes	,
T1206	70-79	VBG	denotes	including
T1207	80-81	NNP	denotes	B
T1208	82-87	NNS	denotes	cells
T1209	87-88	,	denotes	,
T1210	89-100	NNS	denotes	macrophages
T1211	100-101	,	denotes	,
T1212	102-105	CC	denotes	and
T1213	106-115	JJ	denotes	dendritic
T1214	116-121	NNS	denotes	cells
T1215	121-122	,	denotes	,
T1216	123-125	VBZ	denotes	is
T1217	126-134	JJ	denotes	critical
T1218	135-138	IN	denotes	for
T1219	139-142	DT	denotes	the
T1220	143-152	JJ	denotes	efficient
T1221	153-163	NN	denotes	activation
T1222	164-166	IN	denotes	of
T1223	167-174	JJ	denotes	humoral
T1224	175-178	CC	denotes	and
T1225	179-192	JJ	denotes	cell-mediated
T1226	193-199	JJ	denotes	immune
T1227	200-209	NNS	denotes	responses
T1228	210-211	VBP	denotes	[
T1229	211-212	CD	denotes	1
T1230	212-213	NNP	denotes	]
T1231	213-214	,	denotes	,
T1232	215-216	NNP	denotes	[
T1233	216-217	CD	denotes	2
T1234	217-218	NNP	denotes	]
T1235	218-219	,	denotes	,
T1236	220-221	NNP	denotes	[
T1237	221-222	CD	denotes	3
T1238	222-223	NNP	denotes	]
T1239	223-224	.	denotes	.
T1240	225-229	CD	denotes	CD40
T1241	230-239	VBG	denotes	signaling
T1242	240-242	VBZ	denotes	is
T1243	243-252	VBN	denotes	activated
T1244	253-255	IN	denotes	in
T1245	256-257	DT	denotes	a
T1246	258-259	NNP	denotes	T
T1247	260-274	NN	denotes	cell-dependent
T1248	275-281	NN	denotes	manner
T1249	281-282	,	denotes	,
T1250	283-285	IN	denotes	as
T1251	286-289	DT	denotes	the
T1252	290-296	NN	denotes	ligand
T1253	297-300	IN	denotes	for
T1254	301-305	NNP	denotes	CD40
T1255	305-306	,	denotes	,
T1256	307-312	NNP	denotes	CD154
T1257	312-313	,	denotes	,
T1258	314-316	VBZ	denotes	is
T1259	317-326	VBN	denotes	expressed
T1260	327-336	RB	denotes	primarily
T1261	337-339	IN	denotes	by
T1262	340-349	VBN	denotes	activated
T1263	350-351	NNP	denotes	T
T1264	352-357	NNS	denotes	cells
T1265	357-358	.	denotes	.
T1266	359-363	CD	denotes	CD40
T1267	364-374	NN	denotes	engagement
T1268	375-380	VBZ	denotes	leads
T1269	381-383	TO	denotes	to
T1270	384-387	DT	denotes	the
T1271	388-398	NN	denotes	activation
T1272	399-401	IN	denotes	of
T1273	402-409	JJ	denotes	various
T1274	410-419	VBG	denotes	signaling
T1275	420-429	NNS	denotes	molecules
T1276	429-430	,	denotes	,
T1277	431-440	VBG	denotes	including
T1278	441-457	JJ	denotes	stress-activated
T1279	458-465	NN	denotes	protein
T1280	466-473	NNS	denotes	kinases
T1281	474-477	CC	denotes	and
T1282	478-481	DT	denotes	the
T1283	482-495	NN	denotes	transcription
T1284	496-502	NN	denotes	factor
T1285	503-508	NNP	denotes	NF-κB
T1286	508-509	,	denotes	,
T1287	510-515	WDT	denotes	which
T1288	516-526	VBP	denotes	upregulate
T1289	527-530	DT	denotes	the
T1290	531-541	NN	denotes	expression
T1291	542-544	IN	denotes	of
T1292	545-554	NNS	denotes	cytokines
T1293	555-558	CC	denotes	and
T1294	559-564	JJ	denotes	other
T1295	565-572	NNS	denotes	factors
T1296	573-577	WDT	denotes	that
T1297	578-585	VBP	denotes	promote
T1298	586-592	JJ	denotes	immune
T1299	593-602	NNS	denotes	responses
T1300	602-603	.	denotes	.
T1301	604-607	DT	denotes	The
T1302	608-617	NN	denotes	mechanism
T1303	618-620	IN	denotes	by
T1304	621-626	WDT	denotes	which
T1305	627-631	NNP	denotes	CD40
T1306	632-639	VBZ	denotes	induces
T1307	640-645	DT	denotes	these
T1308	646-655	VBG	denotes	signaling
T1309	656-664	NNS	denotes	pathways
T1310	665-668	VBZ	denotes	has
T1311	669-672	RB	denotes	not
T1312	673-677	VBN	denotes	been
T1313	678-688	RB	denotes	completely
T1314	689-696	VBN	denotes	defined
T1315	696-697	.	denotes	.
T1316	698-701	DT	denotes	The
T1317	702-713	JJ	denotes	cytoplasmic
T1318	714-720	NN	denotes	domain
T1319	721-723	IN	denotes	of
T1320	724-728	NNP	denotes	CD40
T1321	729-733	VBZ	denotes	does
T1322	734-737	RB	denotes	not
T1323	738-744	VB	denotes	appear
T1324	745-747	TO	denotes	to
T1325	748-752	VB	denotes	have
T1326	753-762	JJ	denotes	intrinsic
T1327	763-772	JJ	denotes	enzymatic
T1328	773-781	NN	denotes	activity
T1329	781-782	,	denotes	,
T1330	783-786	CC	denotes	but
T1331	787-789	VBZ	denotes	is
T1332	790-794	JJ	denotes	able
T1333	795-797	TO	denotes	to
T1334	798-805	VB	denotes	mediate
T1335	806-815	VBG	denotes	signaling
T1336	816-823	IN	denotes	through
T1337	824-827	DT	denotes	the
T1338	828-839	NN	denotes	recruitment
T1339	840-842	IN	denotes	of
T1340	843-850	JJ	denotes	several
T1341	851-864	JJ	denotes	intracellular
T1342	865-873	NNS	denotes	proteins
T1343	873-874	.	denotes	.
T1344	875-882	NNS	denotes	Members
T1345	883-885	IN	denotes	of
T1346	886-889	DT	denotes	the
T1347	890-893	NNP	denotes	TNF
T1348	894-913	JJ	denotes	receptor-associated
T1349	914-920	NN	denotes	factor
T1350	921-922	-LRB-	denotes	(
T1351	922-926	NNP	denotes	TRAF
T1352	926-927	-RRB-	denotes	)
T1353	928-934	NN	denotes	family
T1354	934-935	,	denotes	,
T1355	936-945	VBG	denotes	including
T1356	946-951	CD	denotes	TRAF1
T1357	951-952	,	denotes	,
T1358	953-958	CD	denotes	TRAF2
T1359	958-959	,	denotes	,
T1360	960-965	CD	denotes	TRAF3
T1361	965-966	,	denotes	,
T1362	967-970	CC	denotes	and
T1363	971-976	NNP	denotes	TRAF6
T1364	976-977	,	denotes	,
T1365	978-984	VBP	denotes	appear
T1366	985-987	TO	denotes	to
T1367	988-990	VB	denotes	be
T1368	991-1003	RB	denotes	particularly
T1369	1004-1013	JJ	denotes	important
T1370	1014-1017	IN	denotes	for
T1371	1018-1021	DT	denotes	the
T1372	1022-1032	NN	denotes	initiation
T1373	1033-1036	CC	denotes	and
T1374	1037-1047	NN	denotes	regulation
T1375	1048-1050	IN	denotes	of
T1376	1051-1055	NNP	denotes	CD40
T1377	1056-1065	VBG	denotes	signaling
T1378	1066-1067	NNP	denotes	[
T1379	1067-1068	CD	denotes	4
T1380	1068-1069	NNP	denotes	]
T1381	1069-1070	.	denotes	.
T1382	1071-1076	DT	denotes	These
T1383	1077-1085	NNS	denotes	proteins
T1384	1086-1094	VBP	denotes	function
T1385	1095-1097	IN	denotes	in
T1386	1098-1102	NN	denotes	part
T1387	1103-1105	IN	denotes	as
T1388	1106-1113	NN	denotes	adaptor
T1389	1114-1123	NNS	denotes	molecules
T1390	1123-1124	,	denotes	,
T1391	1125-1132	JJ	denotes	binding
T1392	1133-1135	TO	denotes	to
T1393	1136-1139	DT	denotes	the
T1394	1140-1151	JJ	denotes	cytoplasmic
T1395	1152-1156	NN	denotes	tail
T1396	1157-1159	IN	denotes	of
T1397	1160-1164	NNP	denotes	CD40
T1398	1165-1168	CC	denotes	and
T1399	1169-1179	VBG	denotes	recruiting
T1400	1180-1185	JJ	denotes	other
T1401	1186-1194	NNS	denotes	proteins
T1402	1195-1197	TO	denotes	to
T1403	1198-1201	DT	denotes	the
T1404	1202-1221	JJ	denotes	receptor-associated
T1405	1222-1229	NN	denotes	complex
T1406	1229-1230	.	denotes	.
T1407	1231-1235	DT	denotes	Some
T1408	1236-1238	IN	denotes	of
T1409	1239-1242	DT	denotes	the
T1410	1243-1248	NNS	denotes	TRAFs
T1411	1249-1253	RB	denotes	also
T1412	1254-1262	VBP	denotes	function
T1413	1263-1265	IN	denotes	as
T1414	1266-1268	CD	denotes	E3
T1415	1269-1278	NN	denotes	ubiquitin
T1416	1279-1286	NNS	denotes	ligases
T1417	1286-1287	,	denotes	,
T1418	1288-1291	CC	denotes	and
T1419	1292-1296	DT	denotes	this
T1420	1297-1306	JJ	denotes	enzymatic
T1421	1307-1315	NN	denotes	activity
T1422	1316-1319	MD	denotes	may
T1423	1320-1330	VB	denotes	contribute
T1424	1331-1333	TO	denotes	to
T1425	1334-1340	VB	denotes	signal
T1426	1341-1352	NN	denotes	propagation
T1427	1353-1356	CC	denotes	and
T1428	1357-1367	NN	denotes	regulation
T1429	1367-1368	.	denotes	.
T1430	1369-1374	IN	denotes	Among
T1431	1375-1378	DT	denotes	the
T1432	1379-1387	JJ	denotes	multiple
T1433	1388-1393	NNS	denotes	TRAFs
T1434	1394-1398	WDT	denotes	that
T1435	1399-1408	VBP	denotes	associate
T1436	1409-1413	IN	denotes	with
T1437	1414-1418	NNP	denotes	CD40
T1438	1418-1419	,	denotes	,
T1439	1420-1425	NNP	denotes	TRAF3
T1440	1426-1429	MD	denotes	can
T1441	1430-1438	VB	denotes	function
T1442	1439-1441	IN	denotes	as
T1443	1442-1443	DT	denotes	a
T1444	1444-1452	JJ	denotes	negative
T1445	1453-1462	NN	denotes	regulator
T1446	1463-1465	IN	denotes	of
T1447	1466-1475	VBG	denotes	signaling
T1448	1475-1476	,	denotes	,
T1449	1477-1482	IN	denotes	while
T1450	1483-1488	CD	denotes	TRAF2
T1451	1489-1492	CC	denotes	and
T1452	1493-1498	CD	denotes	TRAF6
T1453	1499-1506	VB	denotes	promote
T1454	1507-1510	DT	denotes	the
T1455	1511-1521	NN	denotes	activation
T1456	1522-1524	IN	denotes	of
T1457	1525-1535	JJ	denotes	downstream
T1458	1536-1545	VBG	denotes	signaling
T1459	1546-1554	NNS	denotes	pathways
T1460	1555-1556	NNP	denotes	[
T1461	1556-1557	CD	denotes	4
T1462	1557-1558	NNP	denotes	]
T1463	1558-1559	.	denotes	.
T1464	1560-1562	PRP	denotes	We
T1465	1563-1571	RB	denotes	recently
T1466	1572-1584	VBD	denotes	demonstrated
T1467	1585-1589	IN	denotes	that
T1468	1590-1597	JJ	denotes	HOIL-1L
T1469	1598-1609	VBG	denotes	interacting
T1470	1610-1617	NN	denotes	protein
T1471	1618-1619	-LRB-	denotes	(
T1472	1619-1623	NNP	denotes	HOIP
T1473	1623-1624	-RRB-	denotes	)
T1474	1624-1625	,	denotes	,
T1475	1626-1627	DT	denotes	a
T1476	1628-1637	NN	denotes	ubiquitin
T1477	1638-1644	NN	denotes	ligase
T1478	1645-1649	WDT	denotes	that
T1479	1650-1653	MD	denotes	can
T1480	1654-1662	VB	denotes	catalyze
T1481	1663-1666	DT	denotes	the
T1482	1667-1675	NN	denotes	assembly
T1483	1676-1678	IN	denotes	of
T1484	1679-1685	JJ	denotes	linear
T1485	1686-1699	NN	denotes	polyubiquitin
T1486	1700-1706	NNS	denotes	chains
T1487	1707-1708	VBP	denotes	[
T1488	1708-1709	CD	denotes	5
T1489	1709-1710	NNP	denotes	]
T1490	1710-1711	,	denotes	,
T1491	1712-1714	VBZ	denotes	is
T1492	1715-1724	VBN	denotes	recruited
T1493	1725-1727	TO	denotes	to
T1494	1728-1732	NNP	denotes	CD40
T1495	1733-1735	IN	denotes	in
T1496	1736-1737	DT	denotes	a
T1497	1738-1753	JJ	denotes	TRAF2-dependent
T1498	1754-1760	NN	denotes	manner
T1499	1761-1770	VBG	denotes	following
T1500	1771-1781	NN	denotes	engagement
T1501	1782-1784	IN	denotes	of
T1502	1785-1789	CD	denotes	CD40
T1503	1790-1792	IN	denotes	by
T1504	1793-1802	JJ	denotes	agonistic
T1505	1803-1811	NN	denotes	antibody
T1506	1812-1813	NN	denotes	[
T1507	1813-1814	CD	denotes	6
T1508	1814-1815	NNP	denotes	]
T1509	1815-1816	.	denotes	.
T1510	1817-1822	DT	denotes	These
T1511	1823-1826	CC	denotes	and
T1512	1827-1832	JJ	denotes	other
T1513	1833-1841	NNS	denotes	findings
T1514	1842-1845	VBD	denotes	led
T1515	1846-1848	PRP	denotes	us
T1516	1849-1851	TO	denotes	to
T1517	1852-1863	VB	denotes	hypothesize
T1518	1864-1868	DT	denotes	that
T1519	1869-1873	NNP	denotes	HOIP
T1520	1874-1883	NNS	denotes	functions
T1521	1884-1894	JJ	denotes	downstream
T1522	1895-1897	IN	denotes	of
T1523	1898-1903	CD	denotes	TRAF2
T1524	1904-1906	IN	denotes	in
T1525	1907-1910	DT	denotes	the
T1526	1911-1915	NNP	denotes	CD40
T1527	1916-1925	VBG	denotes	signaling
T1528	1926-1933	NN	denotes	pathway
T1529	1934-1937	CC	denotes	and
T1530	1938-1942	IN	denotes	that
T1531	1943-1947	NNP	denotes	HOIP
T1532	1948-1950	VBZ	denotes	is
T1533	1951-1960	JJ	denotes	necessary
T1534	1961-1964	IN	denotes	for
T1535	1965-1968	DT	denotes	the
T1536	1969-1979	NN	denotes	activation
T1537	1980-1982	IN	denotes	of
T1538	1983-1988	NNP	denotes	NF-κB
T1539	1989-1992	CC	denotes	and
T1540	1993-2001	RB	denotes	possibly
T1541	2002-2007	JJ	denotes	other
T1542	2008-2017	VBG	denotes	signaling
T1543	2018-2027	NNS	denotes	molecules
T1544	2027-2028	.	denotes	.
T1545	2029-2031	TO	denotes	To
T1546	2032-2036	VB	denotes	test
T1547	2037-2041	DT	denotes	this
T1548	2042-2052	NN	denotes	hypothesis
T1549	2052-2053	,	denotes	,
T1550	2054-2056	PRP	denotes	we
T1551	2057-2065	VBD	denotes	employed
T1552	2066-2073	JJ	denotes	somatic
T1553	2074-2078	NN	denotes	cell
T1554	2079-2083	NN	denotes	gene
T1555	2084-2093	VBG	denotes	targeting
T1556	2094-2096	TO	denotes	to
T1557	2097-2103	VB	denotes	ablate
T1558	2104-2114	NN	denotes	expression
T1559	2115-2117	IN	denotes	of
T1560	2118-2122	NNP	denotes	HOIP
T1561	2123-2125	IN	denotes	in
T1562	2126-2127	DT	denotes	a
T1563	2128-2133	NN	denotes	mouse
T1564	2134-2135	NNP	denotes	B
T1565	2136-2140	NN	denotes	cell
T1566	2141-2145	NN	denotes	line
T1567	2146-2150	WDT	denotes	that
T1568	2151-2154	VBZ	denotes	has
T1569	2155-2161	VBN	denotes	proven
T1570	2162-2164	TO	denotes	to
T1571	2165-2167	VB	denotes	be
T1572	2168-2169	DT	denotes	a
T1573	2170-2176	JJ	denotes	useful
T1574	2177-2182	NN	denotes	model
T1575	2183-2186	IN	denotes	for
T1576	2187-2188	NNP	denotes	B
T1577	2189-2193	NN	denotes	cell
T1578	2194-2198	CD	denotes	CD40
T1579	2199-2208	VBG	denotes	signaling
T1580	2209-2210	NN	denotes	[
T1581	2210-2211	CD	denotes	7
T1582	2211-2212	NNP	denotes	]
T1583	2212-2213	,	denotes	,
T1584	2214-2215	NNP	denotes	[
T1585	2215-2216	CD	denotes	8
T1586	2216-2217	NNP	denotes	]
T1587	2217-2218	,	denotes	,
T1588	2219-2220	NNP	denotes	[
T1589	2220-2221	CD	denotes	9
T1590	2221-2222	NNP	denotes	]
T1591	2222-2223	.	denotes	.
T1592	2224-2226	PRP	denotes	We
T1593	2227-2232	VBD	denotes	found
T1594	2233-2237	IN	denotes	that
T1595	2238-2241	DT	denotes	the
T1596	2242-2254	JJ	denotes	CD40-induced
T1597	2255-2267	NN	denotes	upregulation
T1598	2268-2270	IN	denotes	of
T1599	2271-2275	NNP	denotes	CD80
T1600	2276-2277	-LRB-	denotes	(
T1601	2277-2278	DT	denotes	a
T1602	2279-2292	JJ	denotes	costimulatory
T1603	2293-2301	NN	denotes	molecule
T1604	2302-2305	IN	denotes	for
T1605	2306-2307	NNP	denotes	T
T1606	2308-2313	NNS	denotes	cells
T1607	2313-2314	-RRB-	denotes	)
T1608	2315-2318	VBD	denotes	was
T1609	2319-2328	JJ	denotes	defective
T1610	2329-2331	IN	denotes	in
T1611	2332-2346	JJ	denotes	HOIP-deficient
T1612	2347-2352	NNS	denotes	cells
T1613	2352-2353	.	denotes	.
T1614	2354-2363	RB	denotes	Similarly
T1615	2363-2364	,	denotes	,
T1616	2365-2368	DT	denotes	the
T1617	2369-2373	NNP	denotes	CD40
T1618	2374-2377	CC	denotes	and
T1619	2378-2382	NN	denotes	IL-4
T1620	2383-2389	VBN	denotes	driven
T1621	2390-2400	NN	denotes	production
T1622	2401-2403	IN	denotes	of
T1623	2404-2412	NN	denotes	germline
T1624	2413-2424	NNS	denotes	transcripts
T1625	2425-2429	IN	denotes	from
T1626	2430-2433	DT	denotes	the
T1627	2434-2448	NN	denotes	immunoglobulin
T1628	2449-2456	NN	denotes	epsilon
T1629	2457-2462	JJ	denotes	heavy
T1630	2463-2468	NN	denotes	chain
T1631	2469-2474	NN	denotes	locus
T1632	2474-2475	,	denotes	,
T1633	2476-2478	DT	denotes	an
T1634	2479-2484	NN	denotes	event
T1635	2485-2489	WDT	denotes	that
T1636	2490-2498	VBZ	denotes	precedes
T1637	2499-2513	NN	denotes	immunoglobulin
T1638	2514-2518	NN	denotes	gene
T1639	2519-2532	NN	denotes	rearrangement
T1640	2533-2536	CC	denotes	and
T1641	2537-2544	NN	denotes	isotype
T1642	2545-2554	NN	denotes	switching
T1643	2554-2555	,	denotes	,
T1644	2556-2559	VBD	denotes	was
T1645	2560-2569	JJ	denotes	defective
T1646	2570-2572	IN	denotes	in
T1647	2573-2576	DT	denotes	the
T1648	2577-2584	NN	denotes	absence
T1649	2585-2587	IN	denotes	of
T1650	2588-2592	NNP	denotes	HOIP
T1651	2592-2593	.	denotes	.
T1652	2594-2596	PRP	denotes	We
T1653	2597-2601	RB	denotes	also
T1654	2602-2607	VBD	denotes	found
T1655	2608-2612	IN	denotes	that
T1656	2613-2616	DT	denotes	the
T1657	2617-2630	JJ	denotes	CD40-mediated
T1658	2631-2641	NN	denotes	activation
T1659	2642-2644	IN	denotes	of
T1660	2645-2650	NNP	denotes	NF-κB
T1661	2651-2654	CC	denotes	and
T1662	2655-2658	DT	denotes	the
T1663	2659-2675	JJ	denotes	stress-activated
T1664	2676-2683	NN	denotes	protein
T1665	2684-2690	NN	denotes	kinase
T1666	2691-2696	JJ	denotes	c-Jun
T1667	2697-2703	NN	denotes	kinase
T1668	2704-2705	-LRB-	denotes	(
T1669	2705-2708	NNP	denotes	JNK
T1670	2708-2709	-RRB-	denotes	)
T1671	2710-2713	VBD	denotes	was
T1672	2714-2723	JJ	denotes	defective
T1673	2724-2726	IN	denotes	in
T1674	2727-2741	JJ	denotes	HOIP-deficient
T1675	2742-2747	NNS	denotes	cells
T1676	2747-2748	.	denotes	.
T1677	2749-2759	JJ	denotes	Consistent
T1678	2760-2764	IN	denotes	with
T1679	2765-2773	JJ	denotes	impaired
T1680	2774-2779	NN	denotes	NF-κB
T1681	2780-2790	NN	denotes	activation
T1682	2790-2791	,	denotes	,
T1683	2792-2803	NN	denotes	association
T1684	2804-2806	IN	denotes	of
T1685	2807-2810	DT	denotes	the
T1686	2811-2814	NNP	denotes	IκB
T1687	2815-2821	NN	denotes	kinase
T1688	2822-2823	-LRB-	denotes	(
T1689	2823-2826	NNP	denotes	IKK
T1690	2826-2827	-RRB-	denotes	)
T1691	2828-2835	JJ	denotes	complex
T1692	2836-2840	IN	denotes	with
T1693	2841-2845	NNP	denotes	CD40
T1694	2846-2849	VBD	denotes	was
T1695	2850-2862	JJ	denotes	undetectable
T1696	2863-2865	IN	denotes	in
T1697	2866-2880	JJ	denotes	HOIP-deficient
T1698	2881-2886	NNS	denotes	cells
T1699	2886-2887	.	denotes	.
T1700	2888-2896	RB	denotes	Together
T1701	2896-2897	,	denotes	,
T1702	2898-2901	PRP$	denotes	our
T1703	2902-2909	NNS	denotes	results
T1704	2910-2918	VBP	denotes	indicate
T1705	2919-2923	IN	denotes	that
T1706	2924-2928	NNP	denotes	HOIP
T1707	2929-2934	VBZ	denotes	plays
T1708	2935-2936	DT	denotes	a
T1709	2937-2945	JJ	denotes	critical
T1710	2946-2950	NN	denotes	role
T1711	2951-2953	IN	denotes	in
T1712	2954-2957	DT	denotes	the
T1713	2958-2968	NN	denotes	activation
T1714	2969-2971	IN	denotes	of
T1715	2972-2981	VBG	denotes	signaling
T1716	2982-2990	NNS	denotes	pathways
T1717	2991-2995	WDT	denotes	that
T1718	2996-3004	VBP	denotes	regulate
T1719	3005-3013	JJ	denotes	cellular
T1720	3014-3023	NNS	denotes	responses
T1721	3024-3026	TO	denotes	to
T1722	3027-3031	CD	denotes	CD40
T1723	3032-3042	NN	denotes	engagement
T1724	3042-3043	.	denotes	.
T6730	1943-1947	NNP	denotes	HOIP
T6731	1948-1950	VBZ	denotes	is
T6732	1951-1960	JJ	denotes	necessary
T6733	1961-1964	IN	denotes	for
T6734	2792-2803	NN	denotes	association
T6735	2804-2806	IN	denotes	of
T6736	2807-2810	DT	denotes	the
R817	T1199	T1200	nummod	CD40,signaling
R818	T1200	T1216	nsubj	signaling,is
R819	T1201	T1200	prep	in,signaling
R820	T1202	T1204	amod	professional,cells
R821	T1203	T1204	amod	antigen-presenting,cells
R822	T1204	T1201	pobj	cells,in
R823	T1205	T1204	punct	",",cells
R824	T1206	T1204	prep	including,cells
R825	T1207	T1208	compound	B,cells
R826	T1208	T1206	pobj	cells,including
R827	T1209	T1208	punct	",",cells
R828	T1210	T1208	conj	macrophages,cells
R829	T1211	T1210	punct	",",macrophages
R830	T1212	T1210	cc	and,macrophages
R831	T1213	T1214	amod	dendritic,cells
R832	T1214	T1210	conj	cells,macrophages
R833	T1215	T1216	punct	",",is
R834	T1216	T1216	ROOT	is,is
R835	T1217	T1216	acomp	critical,is
R836	T1218	T1217	prep	for,critical
R837	T1219	T1221	det	the,activation
R838	T1220	T1221	amod	efficient,activation
R839	T1221	T1218	pobj	activation,for
R840	T1222	T1221	prep	of,activation
R841	T1223	T1227	amod	humoral,responses
R842	T1224	T1223	cc	and,humoral
R843	T1225	T1223	conj	cell-mediated,humoral
R844	T1226	T1227	amod	immune,responses
R845	T1227	T1222	pobj	responses,of
R846	T1228	T1230	nmod	[,]
R847	T1229	T1230	nummod	1,]
R848	T1230	T1216	npadvmod	],is
R849	T1231	T1230	punct	",",]
R850	T1232	T1234	nmod	[,]
R851	T1233	T1234	nummod	2,]
R852	T1234	T1230	conj	],]
R853	T1235	T1234	punct	",",]
R854	T1236	T1234	conj	[,]
R855	T1237	T1238	nummod	3,]
R856	T1238	T1234	conj	],]
R857	T1239	T1216	punct	.,is
R858	T1240	T1243	nsubjpass	CD40,activated
R859	T1241	T1243	nsubjpass	signaling,activated
R860	T1242	T1243	auxpass	is,activated
R861	T1243	T1243	ROOT	activated,activated
R862	T1244	T1243	prep	in,activated
R863	T1245	T1248	det	a,manner
R864	T1246	T1248	compound	T,manner
R865	T1247	T1248	compound	cell-dependent,manner
R866	T1248	T1244	pobj	manner,in
R867	T1249	T1243	punct	",",activated
R868	T1250	T1259	prep	as,expressed
R869	T1251	T1252	det	the,ligand
R870	T1252	T1250	pobj	ligand,as
R871	T1253	T1252	prep	for,ligand
R872	T1254	T1253	pobj	CD40,for
R873	T1255	T1254	punct	",",CD40
R874	T1256	T1254	appos	CD154,CD40
R875	T1257	T1259	punct	",",expressed
R876	T1258	T1259	auxpass	is,expressed
R877	T1259	T1243	advcl	expressed,activated
R878	T1260	T1261	advmod	primarily,by
R879	T1261	T1259	agent	by,expressed
R880	T1262	T1264	amod	activated,cells
R881	T1263	T1264	compound	T,cells
R882	T1264	T1261	pobj	cells,by
R883	T1265	T1243	punct	.,activated
R884	T1266	T1267	nummod	CD40,engagement
R885	T1267	T1268	nsubj	engagement,leads
R886	T1268	T1268	ROOT	leads,leads
R887	T1269	T1268	prep	to,leads
R888	T1270	T1271	det	the,activation
R889	T1271	T1269	pobj	activation,to
R890	T1272	T1271	prep	of,activation
R891	T1273	T1275	amod	various,molecules
R892	T1274	T1275	amod	signaling,molecules
R893	T1275	T1272	pobj	molecules,of
R894	T1276	T1275	punct	",",molecules
R895	T1277	T1275	prep	including,molecules
R896	T1278	T1280	amod	stress-activated,kinases
R897	T1279	T1280	compound	protein,kinases
R898	T1280	T1277	pobj	kinases,including
R899	T1281	T1280	cc	and,kinases
R900	T1282	T1284	det	the,factor
R901	T1283	T1284	compound	transcription,factor
R902	T1284	T1280	conj	factor,kinases
R903	T1285	T1284	appos	NF-κB,factor
R904	T1286	T1284	punct	",",factor
R905	T1287	T1288	nsubj	which,upregulate
R906	T1288	T1284	relcl	upregulate,factor
R907	T1289	T1290	det	the,expression
R908	T1290	T1288	dobj	expression,upregulate
R909	T1291	T1290	prep	of,expression
R910	T1292	T1291	pobj	cytokines,of
R911	T1293	T1292	cc	and,cytokines
R912	T1294	T1295	amod	other,factors
R913	T1295	T1292	conj	factors,cytokines
R914	T1296	T1297	nsubj	that,promote
R915	T1297	T1292	relcl	promote,cytokines
R916	T1298	T1299	amod	immune,responses
R917	T1299	T1297	dobj	responses,promote
R918	T1300	T1268	punct	.,leads
R919	T1301	T1302	det	The,mechanism
R920	T1302	T1314	nsubjpass	mechanism,defined
R921	T1303	T1306	prep	by,induces
R922	T1304	T1303	pobj	which,by
R923	T1305	T1306	nsubj	CD40,induces
R924	T1306	T1302	relcl	induces,mechanism
R925	T1307	T1309	det	these,pathways
R926	T1308	T1309	amod	signaling,pathways
R927	T1309	T1306	dobj	pathways,induces
R928	T1310	T1314	aux	has,defined
R929	T1311	T1314	neg	not,defined
R930	T1312	T1314	auxpass	been,defined
R931	T1313	T1314	advmod	completely,defined
R932	T1314	T1314	ROOT	defined,defined
R933	T1315	T1314	punct	.,defined
R934	T1316	T1318	det	The,domain
R935	T1317	T1318	amod	cytoplasmic,domain
R936	T1318	T1323	nsubj	domain,appear
R937	T1319	T1318	prep	of,domain
R938	T1320	T1319	pobj	CD40,of
R939	T1321	T1323	aux	does,appear
R940	T1322	T1323	neg	not,appear
R941	T1323	T1323	ROOT	appear,appear
R942	T1324	T1325	aux	to,have
R943	T1325	T1323	xcomp	have,appear
R944	T1326	T1328	amod	intrinsic,activity
R945	T1327	T1328	amod	enzymatic,activity
R946	T1328	T1325	dobj	activity,have
R947	T1329	T1323	punct	",",appear
R948	T1330	T1323	cc	but,appear
R949	T1331	T1323	conj	is,appear
R950	T1332	T1331	acomp	able,is
R951	T1333	T1334	aux	to,mediate
R952	T1334	T1332	xcomp	mediate,able
R953	T1335	T1334	dobj	signaling,mediate
R954	T1336	T1335	prep	through,signaling
R955	T1337	T1338	det	the,recruitment
R956	T1338	T1336	pobj	recruitment,through
R957	T1339	T1338	prep	of,recruitment
R958	T1340	T1342	amod	several,proteins
R959	T1341	T1342	amod	intracellular,proteins
R960	T1342	T1339	pobj	proteins,of
R961	T1343	T1331	punct	.,is
R962	T1344	T1365	nsubj	Members,appear
R963	T1345	T1344	prep	of,Members
R964	T1346	T1349	det	the,factor
R965	T1347	T1349	nmod	TNF,factor
R966	T1348	T1349	amod	receptor-associated,factor
R967	T1349	T1345	pobj	factor,of
R968	T1350	T1349	punct	(,factor
R969	T1351	T1349	appos	TRAF,factor
R970	T1352	T1351	punct	),TRAF
R971	T1353	T1349	conj	family,factor
R972	T1354	T1353	punct	",",family
R973	T1355	T1344	prep	including,Members
R974	T1356	T1355	pobj	TRAF1,including
R975	T1357	T1356	punct	",",TRAF1
R976	T1358	T1356	appos	TRAF2,TRAF1
R977	T1359	T1356	punct	",",TRAF1
R978	T1360	T1356	appos	TRAF3,TRAF1
R979	T1361	T1344	punct	",",Members
R980	T1362	T1344	cc	and,Members
R981	T1363	T1365	nsubj	TRAF6,appear
R982	T1364	T1365	punct	",",appear
R983	T1365	T1365	ROOT	appear,appear
R984	T1366	T1367	aux	to,be
R985	T1367	T1365	xcomp	be,appear
R986	T1368	T1369	advmod	particularly,important
R987	T1369	T1367	acomp	important,be
R988	T1370	T1369	prep	for,important
R989	T1371	T1372	det	the,initiation
R990	T1372	T1370	pobj	initiation,for
R991	T1373	T1372	cc	and,initiation
R992	T1374	T1372	conj	regulation,initiation
R993	T1375	T1372	prep	of,initiation
R994	T1376	T1375	pobj	CD40,of
R995	T1377	T1367	advcl	signaling,be
R996	T1378	T1380	nmod	[,]
R997	T1379	T1380	nummod	4,]
R998	T1380	T1377	dobj	],signaling
R999	T1381	T1365	punct	.,appear
R1000	T1382	T1383	det	These,proteins
R1001	T1383	T1384	nsubj	proteins,function
R1002	T1384	T1384	ROOT	function,function
R1003	T1385	T1384	prep	in,function
R1004	T1386	T1385	pobj	part,in
R1005	T1387	T1384	prep	as,function
R1006	T1388	T1389	compound	adaptor,molecules
R1007	T1389	T1387	pobj	molecules,as
R1008	T1390	T1389	punct	",",molecules
R1009	T1391	T1384	advcl	binding,function
R1010	T1392	T1391	prep	to,binding
R1011	T1393	T1395	det	the,tail
R1012	T1394	T1395	amod	cytoplasmic,tail
R1013	T1395	T1392	pobj	tail,to
R1014	T1396	T1395	prep	of,tail
R1015	T1397	T1396	pobj	CD40,of
R1016	T1398	T1395	cc	and,tail
R1017	T1399	T1384	advcl	recruiting,function
R1018	T1400	T1401	amod	other,proteins
R1019	T1401	T1399	dobj	proteins,recruiting
R1020	T1402	T1399	prep	to,recruiting
R1021	T1403	T1405	det	the,complex
R1022	T1404	T1405	compound	receptor-associated,complex
R1023	T1405	T1402	pobj	complex,to
R1024	T1406	T1384	punct	.,function
R1025	T1407	T1412	nsubj	Some,function
R1026	T1408	T1407	prep	of,Some
R1027	T1409	T1410	det	the,TRAFs
R1028	T1410	T1408	pobj	TRAFs,of
R1029	T1411	T1412	advmod	also,function
R1030	T1412	T1412	ROOT	function,function
R1031	T1413	T1412	prep	as,function
R1032	T1414	T1416	nummod	E3,ligases
R1033	T1415	T1416	compound	ubiquitin,ligases
R1034	T1416	T1413	pobj	ligases,as
R1035	T1417	T1412	punct	",",function
R1036	T1418	T1412	cc	and,function
R1037	T1419	T1421	det	this,activity
R1038	T1420	T1421	amod	enzymatic,activity
R1039	T1421	T1423	nsubj	activity,contribute
R1040	T1422	T1423	aux	may,contribute
R1041	T1423	T1412	conj	contribute,function
R1042	T1424	T1425	aux	to,signal
R1043	T1425	T1423	xcomp	signal,contribute
R1044	T1426	T1425	dobj	propagation,signal
R1045	T1427	T1426	cc	and,propagation
R1046	T1428	T1426	conj	regulation,propagation
R1047	T1429	T1412	punct	.,function
R1048	T1430	T1441	prep	Among,function
R1049	T1431	T1433	det	the,TRAFs
R1050	T1432	T1433	amod	multiple,TRAFs
R1051	T1433	T1430	pobj	TRAFs,Among
R1052	T1434	T1435	nsubj	that,associate
R1053	T1435	T1433	relcl	associate,TRAFs
R1054	T1436	T1435	prep	with,associate
R1055	T1437	T1436	pobj	CD40,with
R1056	T1438	T1441	punct	",",function
R1057	T1439	T1441	nsubj	TRAF3,function
R1058	T1440	T1441	aux	can,function
R1059	T1441	T1441	ROOT	function,function
R1060	T1442	T1441	prep	as,function
R1061	T1443	T1445	det	a,regulator
R1062	T1444	T1445	amod	negative,regulator
R1063	T1445	T1442	pobj	regulator,as
R1064	T1446	T1445	prep	of,regulator
R1065	T1447	T1446	pcomp	signaling,of
R1066	T1448	T1441	punct	",",function
R1067	T1449	T1453	mark	while,promote
R1068	T1450	T1453	nsubj	TRAF2,promote
R1069	T1451	T1450	cc	and,TRAF2
R1070	T1452	T1450	conj	TRAF6,TRAF2
R1071	T1453	T1441	advcl	promote,function
R1072	T1454	T1455	det	the,activation
R1073	T1455	T1453	dobj	activation,promote
R1074	T1456	T1455	prep	of,activation
R1075	T1457	T1459	amod	downstream,pathways
R1076	T1458	T1459	compound	signaling,pathways
R1077	T1459	T1456	pobj	pathways,of
R1078	T1460	T1462	nmod	[,]
R1079	T1461	T1462	nummod	4,]
R1080	T1462	T1455	appos	],activation
R1081	T1463	T1441	punct	.,function
R1082	T1464	T1466	nsubj	We,demonstrated
R1083	T1465	T1466	advmod	recently,demonstrated
R1084	T1466	T1466	ROOT	demonstrated,demonstrated
R1085	T1467	T1487	mark	that,[
R1086	T1468	T1470	amod	HOIL-1L,protein
R1087	T1469	T1470	amod	interacting,protein
R1088	T1470	T1487	nsubj	protein,[
R1089	T1471	T1470	punct	(,protein
R1090	T1472	T1470	appos	HOIP,protein
R1091	T1473	T1470	punct	),protein
R1092	T1474	T1470	punct	",",protein
R1093	T1475	T1477	det	a,ligase
R1094	T1476	T1477	compound	ubiquitin,ligase
R1095	T1477	T1470	appos	ligase,protein
R1096	T1478	T1480	nsubj	that,catalyze
R1097	T1479	T1480	aux	can,catalyze
R1098	T1480	T1477	relcl	catalyze,ligase
R1099	T1481	T1482	det	the,assembly
R1100	T1482	T1480	dobj	assembly,catalyze
R1101	T1483	T1482	prep	of,assembly
R1102	T1484	T1486	amod	linear,chains
R1103	T1485	T1486	compound	polyubiquitin,chains
R1104	T1486	T1483	pobj	chains,of
R1105	T1487	T1466	ccomp	[,demonstrated
R1106	T1488	T1489	nummod	5,]
R1107	T1489	T1487	dobj	],[
R1108	T1490	T1492	punct	",",recruited
R1109	T1491	T1492	auxpass	is,recruited
R1110	T1492	T1466	conj	recruited,demonstrated
R1111	T1493	T1492	prep	to,recruited
R1112	T1494	T1493	pobj	CD40,to
R1113	T1495	T1492	prep	in,recruited
R1114	T1496	T1498	det	a,manner
R1115	T1497	T1498	amod	TRAF2-dependent,manner
R1116	T1498	T1495	pobj	manner,in
R1117	T1499	T1492	prep	following,recruited
R1118	T1500	T1499	pobj	engagement,following
R1119	T1501	T1500	prep	of,engagement
R1120	T1502	T1501	pobj	CD40,of
R1121	T1503	T1500	prep	by,engagement
R1122	T1504	T1506	amod	agonistic,[
R1123	T1505	T1506	compound	antibody,[
R1124	T1506	T1508	nmod	[,]
R1125	T1507	T1508	nummod	6,]
R1126	T1508	T1503	pobj	],by
R1127	T1509	T1466	punct	.,demonstrated
R1128	T1510	T1513	det	These,findings
R1129	T1511	T1510	cc	and,These
R1130	T1512	T1513	amod	other,findings
R1131	T1513	T1514	nsubj	findings,led
R1132	T1514	T1514	ROOT	led,led
R1133	T1515	T1514	dobj	us,led
R1134	T1516	T1517	aux	to,hypothesize
R1135	T1517	T1514	xcomp	hypothesize,led
R1136	T1518	T1520	det	that,functions
R1137	T1519	T1520	compound	HOIP,functions
R1138	T1520	T1517	dobj	functions,hypothesize
R1139	T1521	T1520	dobj	downstream,functions
R1140	T1522	T1521	prep	of,downstream
R1141	T1523	T1522	pobj	TRAF2,of
R1142	T1524	T1521	prep	in,downstream
R1143	T1525	T1526	det	the,CD40
R1144	T1526	T1524	pobj	CD40,in
R1145	T1527	T1520	prep	signaling,functions
R1146	T1528	T1527	dobj	pathway,signaling
R1147	T1529	T1520	cc	and,functions
R1148	T1530	T1532	mark	that,is
R1149	T1531	T1532	nsubj	HOIP,is
R1150	T1532	T1520	conj	is,functions
R1151	T1533	T1532	acomp	necessary,is
R1152	T1534	T1532	prep	for,is
R1153	T1535	T1536	det	the,activation
R1154	T1536	T1534	pobj	activation,for
R1155	T1537	T1536	prep	of,activation
R1156	T1538	T1537	pobj	NF-κB,of
R1157	T1539	T1536	cc	and,activation
R1158	T1540	T1543	advmod	possibly,molecules
R1159	T1541	T1543	amod	other,molecules
R1160	T1542	T1543	amod	signaling,molecules
R1161	T1543	T1536	conj	molecules,activation
R1162	T1544	T1514	punct	.,led
R1163	T1545	T1546	aux	To,test
R1164	T1546	T1551	advcl	test,employed
R1165	T1547	T1548	det	this,hypothesis
R1166	T1548	T1546	dobj	hypothesis,test
R1167	T1549	T1551	punct	",",employed
R1168	T1550	T1551	nsubj	we,employed
R1169	T1551	T1551	ROOT	employed,employed
R1170	T1552	T1554	amod	somatic,gene
R1171	T1553	T1554	compound	cell,gene
R1172	T1554	T1551	dobj	gene,employed
R1173	T1555	T1554	acl	targeting,gene
R1174	T1556	T1557	aux	to,ablate
R1175	T1557	T1555	xcomp	ablate,targeting
R1176	T1558	T1557	dobj	expression,ablate
R1177	T1559	T1558	prep	of,expression
R1178	T1560	T1559	pobj	HOIP,of
R1179	T1561	T1557	prep	in,ablate
R1180	T1562	T1566	det	a,line
R1181	T1563	T1565	compound	mouse,cell
R1182	T1564	T1565	compound	B,cell
R1183	T1565	T1566	compound	cell,line
R1184	T1566	T1561	pobj	line,in
R1185	T1567	T1569	nsubj	that,proven
R1186	T1568	T1569	aux	has,proven
R1187	T1569	T1566	relcl	proven,line
R1188	T1570	T1571	aux	to,be
R1189	T1571	T1569	xcomp	be,proven
R1190	T1572	T1574	det	a,model
R1191	T1573	T1574	amod	useful,model
R1192	T1574	T1571	attr	model,be
R1193	T1575	T1574	prep	for,model
R1194	T1576	T1577	compound	B,cell
R1195	T1577	T1575	pobj	cell,for
R1196	T1578	T1577	nummod	CD40,cell
R1197	T1579	T1574	acl	signaling,model
R1198	T1580	T1579	dobj	[,signaling
R1199	T1581	T1580	nummod	7,[
R1200	T1582	T1580	conj	],[
R1201	T1583	T1582	punct	",",]
R1202	T1584	T1586	nmod	[,]
R1203	T1585	T1586	nummod	8,]
R1204	T1586	T1582	conj	],]
R1205	T1587	T1586	punct	",",]
R1206	T1588	T1590	det	[,]
R1207	T1589	T1590	nummod	9,]
R1208	T1590	T1586	appos	],]
R1209	T1591	T1551	punct	.,employed
R1210	T1592	T1593	nsubj	We,found
R1211	T1593	T1593	ROOT	found,found
R1212	T1594	T1608	mark	that,was
R1213	T1595	T1597	det	the,upregulation
R1214	T1596	T1597	amod	CD40-induced,upregulation
R1215	T1597	T1608	nsubj	upregulation,was
R1216	T1598	T1597	prep	of,upregulation
R1217	T1599	T1598	pobj	CD80,of
R1218	T1600	T1599	punct	(,CD80
R1219	T1601	T1603	det	a,molecule
R1220	T1602	T1603	amod	costimulatory,molecule
R1221	T1603	T1599	appos	molecule,CD80
R1222	T1604	T1603	prep	for,molecule
R1223	T1605	T1606	compound	T,cells
R1224	T1606	T1604	pobj	cells,for
R1225	T1607	T1599	punct	),CD80
R1226	T1608	T1593	ccomp	was,found
R1227	T1609	T1608	acomp	defective,was
R1228	T1610	T1609	prep	in,defective
R1229	T1611	T1612	amod	HOIP-deficient,cells
R1230	T1612	T1610	pobj	cells,in
R1231	T1613	T1593	punct	.,found
R1232	T1614	T1620	advmod	Similarly,driven
R1233	T1615	T1620	punct	",",driven
R1234	T1616	T1617	det	the,CD40
R1235	T1617	T1620	nsubj	CD40,driven
R1236	T1618	T1617	cc	and,CD40
R1237	T1619	T1617	conj	IL-4,CD40
R1238	T1620	T1620	ROOT	driven,driven
R1239	T1621	T1620	dobj	production,driven
R1240	T1622	T1621	prep	of,production
R1241	T1623	T1624	compound	germline,transcripts
R1242	T1624	T1622	pobj	transcripts,of
R1243	T1625	T1624	prep	from,transcripts
R1244	T1626	T1631	det	the,locus
R1245	T1627	T1631	amod	immunoglobulin,locus
R1246	T1628	T1631	amod	epsilon,locus
R1247	T1629	T1631	amod	heavy,locus
R1248	T1630	T1631	compound	chain,locus
R1249	T1631	T1625	pobj	locus,from
R1250	T1632	T1620	punct	",",driven
R1251	T1633	T1634	det	an,event
R1252	T1634	T1620	npadvmod	event,driven
R1253	T1635	T1636	nsubj	that,precedes
R1254	T1636	T1634	relcl	precedes,event
R1255	T1637	T1639	compound	immunoglobulin,rearrangement
R1256	T1638	T1639	compound	gene,rearrangement
R1257	T1639	T1636	dobj	rearrangement,precedes
R1258	T1640	T1639	cc	and,rearrangement
R1259	T1641	T1642	compound	isotype,switching
R1260	T1642	T1639	conj	switching,rearrangement
R1261	T1643	T1620	punct	",",driven
R1262	T1644	T1620	conj	was,driven
R1263	T1645	T1644	acomp	defective,was
R1264	T1646	T1644	prep	in,was
R1265	T1647	T1648	det	the,absence
R1266	T1648	T1646	pobj	absence,in
R1267	T1649	T1648	prep	of,absence
R1268	T1650	T1649	pobj	HOIP,of
R1269	T1651	T1620	punct	.,driven
R1270	T1652	T1654	nsubj	We,found
R1271	T1653	T1654	advmod	also,found
R1272	T1654	T1654	ROOT	found,found
R1273	T1655	T1671	mark	that,was
R1274	T1656	T1658	det	the,activation
R1275	T1657	T1658	amod	CD40-mediated,activation
R1276	T1658	T1671	nsubj	activation,was
R1277	T1659	T1658	prep	of,activation
R1278	T1660	T1659	pobj	NF-κB,of
R1279	T1661	T1660	cc	and,NF-κB
R1280	T1662	T1667	det	the,kinase
R1281	T1663	T1667	amod	stress-activated,kinase
R1282	T1664	T1667	nmod	protein,kinase
R1283	T1665	T1667	nmod	kinase,kinase
R1284	T1666	T1667	amod	c-Jun,kinase
R1285	T1667	T1660	conj	kinase,NF-κB
R1286	T1668	T1669	punct	(,JNK
R1287	T1669	T1667	appos	JNK,kinase
R1288	T1670	T1667	punct	),kinase
R1289	T1671	T1654	ccomp	was,found
R1290	T1672	T1671	acomp	defective,was
R1291	T1673	T1672	prep	in,defective
R1292	T1674	T1675	amod	HOIP-deficient,cells
R1293	T1675	T1673	pobj	cells,in
R1294	T1676	T1654	punct	.,found
R1295	T1677	T1694	nsubj	Consistent,was
R1296	T1678	T1677	prep	with,Consistent
R1297	T1679	T1681	amod	impaired,activation
R1298	T1680	T1681	compound	NF-κB,activation
R1299	T1681	T1678	pobj	activation,with
R1300	T1682	T1681	punct	",",activation
R1301	T1683	T1681	conj	association,activation
R1302	T1684	T1681	prep	of,activation
R1303	T1685	T1687	det	the,kinase
R1304	T1686	T1687	compound	IκB,kinase
R1305	T1687	T1684	pobj	kinase,of
R1306	T1688	T1689	punct	(,IKK
R1307	T1689	T1687	appos	IKK,kinase
R1308	T1690	T1689	punct	),IKK
R1309	T1691	T1681	amod	complex,activation
R1310	T1692	T1681	prep	with,activation
R1311	T1693	T1692	pobj	CD40,with
R1312	T1694	T1694	ROOT	was,was
R1313	T1695	T1694	acomp	undetectable,was
R1314	T1696	T1695	prep	in,undetectable
R1315	T1697	T1698	amod	HOIP-deficient,cells
R1316	T1698	T1696	pobj	cells,in
R1317	T1699	T1694	punct	.,was
R1318	T1700	T1704	advmod	Together,indicate
R1319	T1701	T1704	punct	",",indicate
R1320	T1702	T1703	poss	our,results
R1321	T1703	T1704	nsubj	results,indicate
R1322	T1704	T1704	ROOT	indicate,indicate
R1323	T1705	T1707	mark	that,plays
R1324	T1706	T1707	nsubj	HOIP,plays
R1325	T1707	T1704	ccomp	plays,indicate
R1326	T1708	T1710	det	a,role
R1327	T1709	T1710	amod	critical,role
R1328	T1710	T1707	dobj	role,plays
R1329	T1711	T1710	prep	in,role
R1330	T1712	T1713	det	the,activation
R1331	T1713	T1711	pobj	activation,in
R1332	T1714	T1713	prep	of,activation
R1333	T1715	T1714	pcomp	signaling,of
R1334	T1716	T1715	dobj	pathways,signaling
R1335	T1717	T1718	nsubj	that,regulate
R1336	T1718	T1716	relcl	regulate,pathways
R1337	T1719	T1720	amod	cellular,responses
R1338	T1720	T1718	dobj	responses,regulate
R1339	T1721	T1718	prep	to,regulate
R1340	T1722	T1723	nummod	CD40,engagement
R1341	T1723	T1721	pobj	engagement,to
R1342	T1724	T1704	punct	.,indicate
R5088	T6730	T6731	nsubj	HOIP,is
R5089	T6731	T6731	ROOT	is,is
R5090	T6732	T6731	acomp	necessary,is
R5093	T6735	T6734	prep	of,association

UBERON-AE

Id	Subject	Object	Predicate	Lexical cue
T1113	1152-1156	http://purl.obolibrary.org/obo/UBERON_0002415	denotes	tail

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T2312	18-27	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T2313	230-239	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T2314	410-419	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T2315	646-655	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T2316	806-815	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T2317	1056-1065	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T2318	1466-1475	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T2319	1536-1545	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T2320	1916-1925	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T2321	2008-2017	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T2322	2199-2208	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T2323	2972-2981	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T2324	179-199	http://purl.obolibrary.org/obo/GO_0002449	denotes	cell-mediated immune
T2325	179-199	http://purl.obolibrary.org/obo/GO_0002456	denotes	cell-mediated immune
T2326	179-199	http://purl.obolibrary.org/obo/GO_0019724	denotes	cell-mediated immune
T2327	179-199	http://purl.obolibrary.org/obo/GO_0002228	denotes	cell-mediated immune
T2328	179-209	http://purl.obolibrary.org/obo/GO_0002443	denotes	cell-mediated immune responses
T2329	179-199	http://purl.obolibrary.org/obo/GO_0001909	denotes	cell-mediated immune
T2330	193-209	http://purl.obolibrary.org/obo/GO_0006955	denotes	immune responses
T2331	586-602	http://purl.obolibrary.org/obo/GO_0006955	denotes	immune responses
T2332	448-473	http://purl.obolibrary.org/obo/GO_0034199	denotes	activated protein kinases
T2333	2666-2690	http://purl.obolibrary.org/obo/GO_0034199	denotes	activated protein kinase
T2334	448-473	http://purl.obolibrary.org/obo/GO_0032147	denotes	activated protein kinases
T2335	2666-2690	http://purl.obolibrary.org/obo/GO_0032147	denotes	activated protein kinase
T2336	448-473	http://purl.obolibrary.org/obo/GO_0030295	denotes	activated protein kinases
T2337	2666-2690	http://purl.obolibrary.org/obo/GO_0030295	denotes	activated protein kinase
T2338	448-473	http://purl.obolibrary.org/obo/GO_0032111	denotes	activated protein kinases
T2339	2666-2690	http://purl.obolibrary.org/obo/GO_0032111	denotes	activated protein kinase
T2340	482-495	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T2341	646-664	http://purl.obolibrary.org/obo/GO_0007165	denotes	signaling pathways
T2342	1536-1554	http://purl.obolibrary.org/obo/GO_0007165	denotes	signaling pathways
T2343	2972-2990	http://purl.obolibrary.org/obo/GO_0007165	denotes	signaling pathways
T2344	1037-1047	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T2345	1357-1367	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T2346	1037-1065	http://purl.obolibrary.org/obo/GO_2000348	denotes	regulation of CD40 signaling
T2347	1911-1933	http://purl.obolibrary.org/obo/GO_2000348	denotes	CD40 signaling pathway
T2348	1266-1268	http://purl.obolibrary.org/obo/GO_0004842	denotes	E3
T2349	1266-1268	http://purl.obolibrary.org/obo/GO_0019787	denotes	E3
T2350	1266-1268	http://purl.obolibrary.org/obo/GO_0061630	denotes	E3
T2351	1266-1268	http://purl.obolibrary.org/obo/GO_0061659	denotes	E3
T2352	1266-1268	http://purl.obolibrary.org/obo/GO_0061660	denotes	E3
T2353	1266-1268	http://purl.obolibrary.org/obo/GO_0061661	denotes	E3
T2354	1266-1268	http://purl.obolibrary.org/obo/GO_0061662	denotes	E3
T2355	1266-1268	http://purl.obolibrary.org/obo/GO_0061663	denotes	E3
T2356	1266-1268	http://purl.obolibrary.org/obo/GO_0061664	denotes	E3
T2357	1266-1268	http://purl.obolibrary.org/obo/GO_0061665	denotes	E3
T2358	1266-1268	http://purl.obolibrary.org/obo/GO_0061666	denotes	E3
T2359	1266-1268	http://purl.obolibrary.org/obo/GO_0061667	denotes	E3
T2360	1536-1557	http://purl.obolibrary.org/obo/GO_0007214	denotes	signaling pathways [4
T2361	1686-1699	http://purl.obolibrary.org/obo/GO_0000209	denotes	polyubiquitin
T2362	1911-1933	http://purl.obolibrary.org/obo/GO_0023035	denotes	CD40 signaling pathway
T2363	1969-1988	http://purl.obolibrary.org/obo/GO_0051092	denotes	activation of NF-κB
T2364	2631-2650	http://purl.obolibrary.org/obo/GO_0051092	denotes	activation of NF-κB
T2365	2774-2790	http://purl.obolibrary.org/obo/GO_0051092	denotes	NF-κB activation
T2366	2537-2554	http://purl.obolibrary.org/obo/GO_0045190	denotes	isotype switching
T2367	2659-2690	http://purl.obolibrary.org/obo/GO_0016909	denotes	stress-activated protein kinase
T2368	2659-2690	http://purl.obolibrary.org/obo/GO_0007254	denotes	stress-activated protein kinase
T2369	2666-2692	http://purl.obolibrary.org/obo/GO_1990051	denotes	activated protein kinase c
T2370	2676-2692	http://purl.obolibrary.org/obo/GO_0004697	denotes	protein kinase c
T2371	2676-2692	http://purl.obolibrary.org/obo/GO_0042313	denotes	protein kinase c
T2372	2676-2692	http://purl.obolibrary.org/obo/GO_0070528	denotes	protein kinase c
T2373	2705-2708	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T2374	2823-2826	http://purl.obolibrary.org/obo/GO_0008384	denotes	IKK
T2375	2958-2990	http://purl.obolibrary.org/obo/GO_0009736	denotes	activation of signaling pathways
T2376	2958-2990	http://purl.obolibrary.org/obo/GO_0033211	denotes	activation of signaling pathways
T2377	2958-2990	http://purl.obolibrary.org/obo/GO_1901186	denotes	activation of signaling pathways
T2378	2958-2990	http://purl.obolibrary.org/obo/GO_1902204	denotes	activation of signaling pathways
T2379	2958-2990	http://purl.obolibrary.org/obo/GO_0009873	denotes	activation of signaling pathways
T2380	2958-2990	http://purl.obolibrary.org/obo/GO_0038084	denotes	activation of signaling pathways
T2381	2958-2990	http://purl.obolibrary.org/obo/GO_1900236	denotes	activation of signaling pathways
T2382	2958-2990	http://purl.obolibrary.org/obo/GO_1902046	denotes	activation of signaling pathways
T2383	2958-2990	http://purl.obolibrary.org/obo/GO_1902843	denotes	activation of signaling pathways
T2384	2958-2990	http://purl.obolibrary.org/obo/GO_1903265	denotes	activation of signaling pathways
T2385	3005-3013	http://purl.obolibrary.org/obo/GO_0007349	denotes	cellular

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T2386	290-296	http://purl.obolibrary.org/obo/GO_0005488	denotes	ligand
T2387	1125-1132	http://purl.obolibrary.org/obo/GO_0005488	denotes	binding
T2388	448-473	http://purl.obolibrary.org/obo/GO_0030295	denotes	activated protein kinases
T2389	2666-2690	http://purl.obolibrary.org/obo/GO_0030295	denotes	activated protein kinase
T2390	1266-1268	http://purl.obolibrary.org/obo/GO_0004842	denotes	E3
T2391	1266-1268	http://purl.obolibrary.org/obo/GO_0019787	denotes	E3
T2392	1266-1268	http://purl.obolibrary.org/obo/GO_0061630	denotes	E3
T2393	1266-1268	http://purl.obolibrary.org/obo/GO_0061659	denotes	E3
T2394	1266-1268	http://purl.obolibrary.org/obo/GO_0061660	denotes	E3
T2395	1266-1268	http://purl.obolibrary.org/obo/GO_0061661	denotes	E3
T2396	1266-1268	http://purl.obolibrary.org/obo/GO_0061662	denotes	E3
T2397	1266-1268	http://purl.obolibrary.org/obo/GO_0061663	denotes	E3
T2398	1266-1268	http://purl.obolibrary.org/obo/GO_0061664	denotes	E3
T2399	1266-1268	http://purl.obolibrary.org/obo/GO_0061665	denotes	E3
T2400	1266-1268	http://purl.obolibrary.org/obo/GO_0061666	denotes	E3
T2401	1266-1268	http://purl.obolibrary.org/obo/GO_0061667	denotes	E3
T2402	1269-1278	http://purl.obolibrary.org/obo/GO_0031386	denotes	ubiquitin
T2403	1628-1637	http://purl.obolibrary.org/obo/GO_0031386	denotes	ubiquitin
T2404	1803-1811	http://purl.obolibrary.org/obo/GO_0003823	denotes	antibody
T2405	2434-2448	http://purl.obolibrary.org/obo/GO_0003823	denotes	immunoglobulin
T2406	2499-2513	http://purl.obolibrary.org/obo/GO_0003823	denotes	immunoglobulin
T2407	2378-2382	http://purl.obolibrary.org/obo/GO_0005136	denotes	IL-4
T2408	2659-2690	http://purl.obolibrary.org/obo/GO_0016909	denotes	stress-activated protein kinase
T2409	2676-2692	http://purl.obolibrary.org/obo/GO_0004697	denotes	protein kinase c
T2410	2676-2692	http://purl.obolibrary.org/obo/GO_0005080	denotes	protein kinase c
T2411	2705-2708	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T2412	2823-2826	http://purl.obolibrary.org/obo/GO_0008384	denotes	IKK

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T2413	63-68	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2414	82-87	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2415	116-121	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2416	352-357	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2417	2308-2313	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2418	2347-2352	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2419	2742-2747	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2420	2881-2886	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2421	851-864	http://purl.obolibrary.org/obo/GO_0005622	denotes	intracellular
T2422	1803-1811	http://purl.obolibrary.org/obo/GO_0019815	denotes	antibody
T2423	1803-1811	http://purl.obolibrary.org/obo/GO_0042571	denotes	antibody
T2424	2823-2835	http://purl.obolibrary.org/obo/GO_0008385	denotes	IKK) complex

sentences

Id	Subject	Object	Predicate	Lexical cue
T1182	13-224	Sentence	denotes	CD40 signaling in professional antigen-presenting cells, including B cells, macrophages, and dendritic cells, is critical for the efficient activation of humoral and cell-mediated immune responses [1], [2], [3].
T1183	225-358	Sentence	denotes	CD40 signaling is activated in a T cell-dependent manner, as the ligand for CD40, CD154, is expressed primarily by activated T cells.
T1184	359-603	Sentence	denotes	CD40 engagement leads to the activation of various signaling molecules, including stress-activated protein kinases and the transcription factor NF-κB, which upregulate the expression of cytokines and other factors that promote immune responses.
T1185	604-697	Sentence	denotes	The mechanism by which CD40 induces these signaling pathways has not been completely defined.
T1186	698-874	Sentence	denotes	The cytoplasmic domain of CD40 does not appear to have intrinsic enzymatic activity, but is able to mediate signaling through the recruitment of several intracellular proteins.
T1187	875-1070	Sentence	denotes	Members of the TNF receptor-associated factor (TRAF) family, including TRAF1, TRAF2, TRAF3, and TRAF6, appear to be particularly important for the initiation and regulation of CD40 signaling [4].
T1188	1071-1230	Sentence	denotes	These proteins function in part as adaptor molecules, binding to the cytoplasmic tail of CD40 and recruiting other proteins to the receptor-associated complex.
T1189	1231-1368	Sentence	denotes	Some of the TRAFs also function as E3 ubiquitin ligases, and this enzymatic activity may contribute to signal propagation and regulation.
T1190	1369-1559	Sentence	denotes	Among the multiple TRAFs that associate with CD40, TRAF3 can function as a negative regulator of signaling, while TRAF2 and TRAF6 promote the activation of downstream signaling pathways [4].
T1191	1560-1816	Sentence	denotes	We recently demonstrated that HOIL-1L interacting protein (HOIP), a ubiquitin ligase that can catalyze the assembly of linear polyubiquitin chains [5], is recruited to CD40 in a TRAF2-dependent manner following engagement of CD40 by agonistic antibody [6].
T1192	1817-2028	Sentence	denotes	These and other findings led us to hypothesize that HOIP functions downstream of TRAF2 in the CD40 signaling pathway and that HOIP is necessary for the activation of NF-κB and possibly other signaling molecules.
T1193	2029-2223	Sentence	denotes	To test this hypothesis, we employed somatic cell gene targeting to ablate expression of HOIP in a mouse B cell line that has proven to be a useful model for B cell CD40 signaling [7], [8], [9].
T1194	2224-2353	Sentence	denotes	We found that the CD40-induced upregulation of CD80 (a costimulatory molecule for T cells) was defective in HOIP-deficient cells.
T1195	2354-2593	Sentence	denotes	Similarly, the CD40 and IL-4 driven production of germline transcripts from the immunoglobulin epsilon heavy chain locus, an event that precedes immunoglobulin gene rearrangement and isotype switching, was defective in the absence of HOIP.
T1196	2594-2748	Sentence	denotes	We also found that the CD40-mediated activation of NF-κB and the stress-activated protein kinase c-Jun kinase (JNK) was defective in HOIP-deficient cells.
T1197	2749-2887	Sentence	denotes	Consistent with impaired NF-κB activation, association of the IκB kinase (IKK) complex with CD40 was undetectable in HOIP-deficient cells.
T1198	2888-3043	Sentence	denotes	Together, our results indicate that HOIP plays a critical role in the activation of signaling pathways that regulate cellular responses to CD40 engagement.
T16	0-12	Sentence	denotes	Introduction
T17	13-224	Sentence	denotes	CD40 signaling in professional antigen-presenting cells, including B cells, macrophages, and dendritic cells, is critical for the efficient activation of humoral and cell-mediated immune responses [1], [2], [3].
T18	225-358	Sentence	denotes	CD40 signaling is activated in a T cell-dependent manner, as the ligand for CD40, CD154, is expressed primarily by activated T cells.
T19	359-603	Sentence	denotes	CD40 engagement leads to the activation of various signaling molecules, including stress-activated protein kinases and the transcription factor NF-κB, which upregulate the expression of cytokines and other factors that promote immune responses.
T20	604-697	Sentence	denotes	The mechanism by which CD40 induces these signaling pathways has not been completely defined.
T21	698-874	Sentence	denotes	The cytoplasmic domain of CD40 does not appear to have intrinsic enzymatic activity, but is able to mediate signaling through the recruitment of several intracellular proteins.
T22	875-1070	Sentence	denotes	Members of the TNF receptor-associated factor (TRAF) family, including TRAF1, TRAF2, TRAF3, and TRAF6, appear to be particularly important for the initiation and regulation of CD40 signaling [4].
T23	1071-1230	Sentence	denotes	These proteins function in part as adaptor molecules, binding to the cytoplasmic tail of CD40 and recruiting other proteins to the receptor-associated complex.
T24	1231-1368	Sentence	denotes	Some of the TRAFs also function as E3 ubiquitin ligases, and this enzymatic activity may contribute to signal propagation and regulation.
T25	1369-1559	Sentence	denotes	Among the multiple TRAFs that associate with CD40, TRAF3 can function as a negative regulator of signaling, while TRAF2 and TRAF6 promote the activation of downstream signaling pathways [4].
T26	1560-1816	Sentence	denotes	We recently demonstrated that HOIL-1L interacting protein (HOIP), a ubiquitin ligase that can catalyze the assembly of linear polyubiquitin chains [5], is recruited to CD40 in a TRAF2-dependent manner following engagement of CD40 by agonistic antibody [6].
T27	1817-2028	Sentence	denotes	These and other findings led us to hypothesize that HOIP functions downstream of TRAF2 in the CD40 signaling pathway and that HOIP is necessary for the activation of NF-κB and possibly other signaling molecules.
T28	2029-2223	Sentence	denotes	To test this hypothesis, we employed somatic cell gene targeting to ablate expression of HOIP in a mouse B cell line that has proven to be a useful model for B cell CD40 signaling [7], [8], [9].
T29	2224-2353	Sentence	denotes	We found that the CD40-induced upregulation of CD80 (a costimulatory molecule for T cells) was defective in HOIP-deficient cells.
T30	2354-2593	Sentence	denotes	Similarly, the CD40 and IL-4 driven production of germline transcripts from the immunoglobulin epsilon heavy chain locus, an event that precedes immunoglobulin gene rearrangement and isotype switching, was defective in the absence of HOIP.
T31	2594-2748	Sentence	denotes	We also found that the CD40-mediated activation of NF-κB and the stress-activated protein kinase c-Jun kinase (JNK) was defective in HOIP-deficient cells.
T32	2749-2887	Sentence	denotes	Consistent with impaired NF-κB activation, association of the IκB kinase (IKK) complex with CD40 was undetectable in HOIP-deficient cells.
T33	2888-3043	Sentence	denotes	Together, our results indicate that HOIP plays a critical role in the activation of signaling pathways that regulate cellular responses to CD40 engagement.

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T2245	13-17	P25942	denotes	CD40
T2246	225-229	P25942	denotes	CD40
T2247	301-305	P25942	denotes	CD40
T2248	307-312	P29965	denotes	CD154
T2249	359-363	P25942	denotes	CD40
T2250	441-473	P53778	denotes	stress-activated protein kinases
T2251	441-473	O15264	denotes	stress-activated protein kinases
T2252	627-631	P25942	denotes	CD40
T2253	724-728	P25942	denotes	CD40
T2254	790-794	P00519	denotes	able
T2255	890-893	P01375	denotes	TNF
T2256	890-920	Q9Y4K3	denotes	TNF receptor-associated factor
T2257	890-920	Q13114	denotes	TNF receptor-associated factor
T2258	890-920	Q12933	denotes	TNF receptor-associated factor
T2259	953-958	Q12933	denotes	TRAF2
T2260	960-965	Q13114	denotes	TRAF3
T2261	971-976	Q9Y4K3	denotes	TRAF6
T2262	1051-1055	P25942	denotes	CD40
T2263	1160-1164	P25942	denotes	CD40
T2264	1414-1418	P25942	denotes	CD40
T2265	1420-1425	Q13114	denotes	TRAF3
T2266	1483-1488	Q12933	denotes	TRAF2
T2267	1493-1498	Q9Y4K3	denotes	TRAF6
T2268	1590-1617	Q96EP0	denotes	HOIL-1L interacting protein
T2269	1619-1623	Q96EP0	denotes	HOIP
T2270	1728-1732	P25942	denotes	CD40
T2271	1738-1743	Q12933	denotes	TRAF2
T2272	1785-1789	P25942	denotes	CD40
T2273	1869-1873	Q96EP0	denotes	HOIP
T2274	1898-1903	Q12933	denotes	TRAF2
T2275	1911-1915	P25942	denotes	CD40
T2276	1943-1947	Q96EP0	denotes	HOIP
T2277	2118-2122	Q96EP0	denotes	HOIP
T2278	2194-2198	P25942	denotes	CD40
T2279	2242-2246	P25942	denotes	CD40
T2280	2271-2275	P33681	denotes	CD80
T2281	2332-2336	Q96EP0	denotes	HOIP
T2282	2369-2373	P25942	denotes	CD40
T2283	2378-2382	P05112	denotes	IL-4
T2284	2588-2592	Q96EP0	denotes	HOIP
T2285	2617-2621	P25942	denotes	CD40
T2286	2691-2696	P05412	denotes	c-Jun
T2287	2693-2696	P05412	denotes	Jun
T2288	2727-2731	Q96EP0	denotes	HOIP
T2289	2811-2821	Q60680-2	denotes	IκB kinase
T2290	2811-2821	O15111	denotes	IκB kinase
T2291	2841-2845	P25942	denotes	CD40
T2292	2866-2870	Q96EP0	denotes	HOIP
T2293	2924-2928	Q96EP0	denotes	HOIP
T2294	3027-3031	P25942	denotes	CD40
T8190	1943-1947	Q96EP0	denotes	HOIP

test2

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T1049	13-17	Protein	denotes	CD40
T1050	225-229	Protein	denotes	CD40
T1051	301-305	Protein	denotes	CD40
T1052	307-312	Protein	denotes	CD154
T1053	317-326	Gene_expression	denotes	expressed
T1054	359-363	Protein	denotes	CD40
T1055	364-374	Binding	denotes	engagement
T1056	627-631	Protein	denotes	CD40
T1057	702-720	Entity	denotes	cytoplasmic domain
T1058	724-728	Protein	denotes	CD40
T1059	828-839	Binding	denotes	recruitment
T1060	946-951	Protein	denotes	TRAF1
T1061	953-958	Protein	denotes	TRAF2
T1062	960-965	Protein	denotes	TRAF3
T1063	971-976	Protein	denotes	TRAF6		true
T1064	1051-1055	Protein	denotes	CD40
T1065	1125-1132	Binding	denotes	binding
T1066	1140-1156	Entity	denotes	cytoplasmic tail
T1067	1160-1164	Protein	denotes	CD40
T1068	1399-1408	Binding	denotes	associate
T1069	1414-1418	Protein	denotes	CD40
T1070	1420-1425	Protein	denotes	TRAF3
T1071	1483-1488	Protein	denotes	TRAF2
T1072	1493-1498	Protein	denotes	TRAF6	true
T1073	1590-1617	Protein	denotes	HOIL-1L interacting protein
T1074	1619-1623	Protein	denotes	HOIP
T1075	1715-1724	Binding	denotes	recruited
T1076	1728-1732	Protein	denotes	CD40
T1077	1738-1743	Protein	denotes	TRAF2
T1078	1744-1753	Regulation	denotes	dependent
T1079	1761-1770	Positive_regulation	denotes	following
T1080	1771-1781	Binding	denotes	engagement
T1081	1785-1789	Protein	denotes	CD40
T1082	1869-1873	Protein	denotes	HOIP
T1083	1884-1894	Regulation	denotes	downstream
T1084	1898-1903	Protein	denotes	TRAF2
T1085	1911-1915	Protein	denotes	CD40
T1086	1943-1947	Protein	denotes	HOIP
T1087	2104-2114	Gene_expression	denotes	expression
T1088	2118-2122	Protein	denotes	HOIP
T1089	2194-2198	Protein	denotes	CD40
T1090	2242-2246	Protein	denotes	CD40
T1091	2247-2254	Positive_regulation	denotes	induced
T1092	2255-2267	Positive_regulation	denotes	upregulation
T1093	2271-2275	Protein	denotes	CD80
T1094	2319-2328	Negative_regulation	denotes	defective
T1095	2332-2336	Protein	denotes	HOIP
T1096	2337-2346	Negative_regulation	denotes	deficient
T1097	2369-2373	Protein	denotes	CD40
T1098	2378-2382	Protein	denotes	IL-4
T1099	2390-2400	Gene_expression	denotes	production
T1100	2560-2569	Negative_regulation	denotes	defective
T1101	2577-2584	Negative_regulation	denotes	absence
T1102	2588-2592	Protein	denotes	HOIP
T1103	2617-2621	Protein	denotes	CD40
T1104	2727-2731	Protein	denotes	HOIP
T1105	2732-2741	Negative_regulation	denotes	deficient
T1106	2792-2803	Binding	denotes	association
T1107	2841-2845	Protein	denotes	CD40
T1108	2866-2870	Protein	denotes	HOIP
T1109	2871-2880	Negative_regulation	denotes	deficient
T1110	2924-2928	Protein	denotes	HOIP
T1111	3027-3031	Protein	denotes	CD40
T1112	3032-3042	Binding	denotes	engagement
T6451	1943-1947	Protein	denotes	HOIP
T6452	1951-1960	Positive_regulation	denotes	necessary
T6453	2792-2803	Binding	denotes	association
R743	T1051	T1053	themeOf	CD40,expressed
R744	T1052	T1053	themeOf	CD154,expressed
R745	T1054	T1055	themeOf	CD40,engagement
R746	T1057	T1058	partOf	cytoplasmic domain,CD40
R747	T1058	T1059	themeOf	CD40,recruitment
R748	T1066	T1067	partOf	cytoplasmic tail,CD40
R749	T1066	T1065	themeOf	cytoplasmic tail,binding
R750	T1069	T1068	themeOf	CD40,associate
R751	T1070	T1068	themeOf	TRAF3,associate
R752	T1071	T1068	themeOf	TRAF2,associate
R753	T1072	T1068	themeOf	TRAF6,associate
R754	T1073	T1075	themeOf	HOIL-1L interacting protein,recruited
R755	T1074	T1073	equivalentTo	HOIP,HOIL-1L interacting protein
R756	T1075	T1079	themeOf	recruited,following
R757	T1075	T1078	themeOf	recruited,dependent
R758	T1076	T1075	themeOf	CD40,recruited
R759	T1077	T1078	causeOf	TRAF2,dependent
R760	T1078	T1079	themeOf	dependent,following
R761	T1080	T1079	causeOf	engagement,following
R762	T1081	T1080	themeOf	CD40,engagement
R763	T1088	T1087	themeOf	HOIP,expression
R764	T1090	T1091	causeOf	CD40,induced
R765	T1091	T1094	themeOf	induced,defective
R766	T1092	T1091	themeOf	upregulation,induced
R767	T1092	T1094	themeOf	upregulation,defective
R768	T1093	T1092	themeOf	CD80,upregulation
R769	T1095	T1096	themeOf	HOIP,deficient
R770	T1096	T1094	causeOf	deficient,defective
R771	T1102	T1101	themeOf	HOIP,absence
R772	T1104	T1105	themeOf	HOIP,deficient
R773	T1107	T1106	themeOf	CD40,association
R774	T1108	T1109	themeOf	HOIP,deficient
R775	T1111	T1112	themeOf	CD40,engagement
R4929	T6451	T6452	causeOf	HOIP,necessary
R4930	T6453	T6452	themeOf	association,necessary

PMC:3148254 / 1857-4900 JSONTXT

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PMC:3148254 / 1857-4900 JSON TXT