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PMC:3148254 / 15212-22083 JSONTXT

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bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T6577 58-62 Protein denotes CD40
T6578 85-89 Protein denotes CD40
T6579 142-146 Protein denotes HOIP
T6580 147-156 Negative_regulation denotes deficient
T6581 178-182 Protein denotes HOIP
T6582 309-313 Protein denotes HOIP
T6583 317-326 Binding denotes recruited
T6584 362-367 Protein denotes TRAF2
T6585 368-377 Regulation denotes dependent
T6586 402-406 Protein denotes HOIP
T6587 407-427 Regulation denotes functions downstream true
T6588 431-436 Protein denotes TRAF2
T6589 477-482 Protein denotes TRAF2
T6590 483-493 Binding denotes associated
T6591 483-493 Binding denotes associated
T6592 503-508 Protein denotes cIAP1
T6593 513-518 Protein denotes cIAP2
T6594 526-530 Regulation denotes role
T6595 526-530 Regulation denotes role
T6596 526-530 Regulation denotes role
T6597 526-530 Regulation denotes role
T6598 538-549 Binding denotes recruitment
T6599 538-549 Binding denotes recruitment
T6600 553-557 Protein denotes HOIP
T6601 561-566 Protein denotes TNFR1
T6602 571-575 Protein denotes CD40
T6603 619-630 Binding denotes association
T6604 634-638 Protein denotes HOIP
T6605 644-648 Protein denotes CD40
T6606 669-676 Regulation denotes altered true
T6607 883-890 Negative_regulation denotes reduced
T6608 905-910 Protein denotes cIAP1
T6609 911-921 Binding denotes associated
T6610 1050-1058 Positive_regulation denotes resulted
T6611 1050-1058 Positive_regulation denotes resulted
T6612 1088-1096 Negative_regulation denotes decrease
T6613 1124-1128 Protein denotes HOIP
T6614 1134-1143 Binding denotes recovered
T6615 1147-1151 Protein denotes CD40
T6616 1196-1204 Positive_regulation denotes increase
T6617 1240-1250 Binding denotes recognized
T6618 1327-1332 Regulation denotes alter true
T6619 1367-1371 Protein denotes HOIP
T6620 1457-1463 Regulation denotes alters
T6621 1487-1491 Protein denotes CD40
T6622 1492-1502 Binding denotes associated
T6623 1503-1507 Protein denotes HOIP
T6624 1612-1616 Protein denotes cIAP
T6625 1626-1635 Regulation denotes influence
T6626 1626-1635 Regulation denotes influence
T6627 1640-1651 Binding denotes recruitment
T6628 1656-1687 Protein_modification denotes post-translational modification
T6629 1697-1701 Protein denotes CD40
T6630 1702-1712 Binding denotes associated
T6631 1713-1717 Protein denotes HOIP
T6632 4201-4205 Protein denotes HOIP
T6633 4209-4220 Regulation denotes responsible true
T6634 4229-4240 Binding denotes recruitment
T6635 4281-4285 Protein denotes CD40
T6636 4339-4343 Protein denotes HOIP
T6637 4344-4353 Negative_regulation denotes deficient
T6638 4358-4362 Protein denotes HOIP
T6639 4363-4376 Positive_regulation denotes reconstituted
T6640 4491-4495 Protein denotes HOIP
T6641 4507-4512 Protein denotes TRAF2
T6642 4514-4519 Protein denotes TRAF3
T6643 4521-4525 Protein denotes IKKα
T6644 4526-4527 Protein denotes β
T6645 4533-4537 Protein denotes IKKγ
T6646 4558-4563 Protein denotes TRAF2
T6647 4565-4570 Protein denotes TRAF3
T6648 4576-4581 Protein denotes cIAP1
T6649 4585-4589 Protein denotes CD40
T6650 4614-4618 Protein denotes HOIP
T6651 4701-4705 Protein denotes HOIP
T6652 4713-4721 Positive_regulation denotes required true
T6653 4713-4721 Positive_regulation denotes required true
T6654 4713-4721 Positive_regulation denotes required true
T6655 4730-4741 Binding denotes association
T6656 4730-4741 Binding denotes association
T6657 4730-4741 Binding denotes association
T6658 4765-4769 Protein denotes CD40
T6659 4784-4788 Protein denotes IKKα
T6660 4789-4790 Protein denotes β
T6661 4795-4799 Protein denotes IKKγ
T6662 4823-4827 Protein denotes CD40
T6663 4862-4866 Protein denotes HOIP
T6664 4867-4876 Negative_regulation denotes deficient
T6665 4911-4915 Protein denotes IKKα
T6666 4916-4917 Protein denotes β
T6667 4922-4926 Protein denotes IKKγ
T6668 4930-4934 Protein denotes CD40
T6669 4959-4963 Protein denotes HOIP
T6670 4964-4977 Positive_regulation denotes reconstituted
T6671 5147-5154 Negative_regulation denotes absence
T6672 5158-5162 Protein denotes HOIP
T6673 5163-5173 Gene_expression denotes expression
T6674 5200-5204 Protein denotes HOIP
T6675 5341-5345 Protein denotes IKKγ
T6676 5357-5361 Protein denotes CD40
T6677 5520-5524 Protein denotes IKKγ
T6678 5654-5658 Protein denotes IKKγ
T6679 5677-5681 Protein denotes CD40
T6680 5919-5923 Protein denotes IKKγ
T6681 5988-5998 Gene_expression denotes expressing
T6682 6014-6018 Protein denotes IKKγ
T6683 6034-6045 Binding denotes recruitment
T6684 6049-6053 Protein denotes IKKγ
T6685 6057-6061 Protein denotes CD40
T6686 6062-6070 Positive_regulation denotes requires
T6687 6071-6075 Protein denotes HOIP
T6688 6149-6153 Protein denotes IKKγ
T6689 6157-6161 Protein denotes CD40
T6690 6363-6367 Protein denotes CD40
T6691 6368-6378 Binding denotes associated
T6692 6379-6383 Protein denotes IKKγ
T6693 6596-6600 Protein denotes CD40
T6694 6601-6611 Binding denotes associated
T6695 6612-6616 Protein denotes IKKγ
T6696 6678-6693 Phosphorylation denotes phosphorylation
T6697 6732-6736 Protein denotes HOIP
T6698 6740-6748 Positive_regulation denotes required
T6699 6757-6768 Binding denotes association
T6700 6772-6776 Protein denotes IKKγ
T6701 6782-6786 Protein denotes CD40
T6702 6819-6826 Positive_regulation denotes coupled
T6703 6830-6862 Protein_modification denotes post-translational modifications
T6704 6866-6870 Protein denotes IKKγ
T16768 1825-1829 Protein denotes HOIP
T16769 1830-1839 Negative_regulation denotes deficient
T16770 1874-1881 Negative_regulation denotes reduces
T16771 1882-1893 Binding denotes recruitment
T16772 1897-1902 Protein denotes cIAP1
T16773 1906-1910 Protein denotes CD40
T16774 1919-1925 Regulation denotes modify true
T16775 1926-1930 Protein denotes HOIP
T16776 1931-1942 Binding denotes recruitment
T16777 2537-2542 Protein denotes cIAP1
T16778 2544-2549 Protein denotes TRAF2
T16779 2551-2556 Protein denotes TRAF3
T16780 2562-2566 Protein denotes HOIP
T16781 2683-2687 Protein denotes CD40
T16782 2758-2762 Protein denotes HOIP
T16783 2763-2772 Negative_regulation denotes deficient
T16784 2861-2865 Protein denotes HOIP
T16785 2997-3001 Protein denotes CD40
T16786 3003-3008 Protein denotes TRAF2
T16787 3010-3015 Protein denotes TRAF3
T16788 3017-3022 Protein denotes cIAP1
T16789 3024-3028 Protein denotes HOIP
T16790 3030-3034 Protein denotes IKKα
T16791 3035-3036 Protein denotes β
T16792 3042-3046 Protein denotes IKKγ
T16793 3063-3067 Protein denotes HOIP
T16794 3068-3078 Gene_expression denotes expression
T16798 3342-3346 Protein denotes HOIP
T16799 3347-3356 Regulation denotes dependent true
T16800 3357-3368 Binding denotes recruitment
T16801 3372-3376 Protein denotes IKKγ
T16802 3380-3384 Protein denotes CD40
T16803 3402-3406 Protein denotes HOIP
T16804 3407-3416 Negative_regulation denotes deficient
T16805 3418-3422 Protein denotes HOIP
T16806 3541-3545 Protein denotes IKKγ
T16807 3570-3574 Protein denotes pMIP
T16808 3579-3583 Protein denotes IKKγ
T16809 3785-3789 Protein denotes IKKγ
T16810 3808-3813 Protein denotes TRAF2
T16811 4073-4078 Protein denotes TRAF3
T16812 4083-4087 Protein denotes HOIP
T16795 3133-3137 Protein denotes CD40
T16796 3296-3300 Protein denotes HOIP
T16797 3301-3310 Negative_regulation denotes deficient
R5004 T6579 T6580 themeOf HOIP,deficient
R5005 T6582 T6583 themeOf HOIP,recruited
R5006 T6583 T6585 themeOf recruited,dependent
R5007 T6584 T6585 causeOf TRAF2,dependent
R5008 T6586 T6587 themeOf HOIP,functions downstream
R5009 T6588 T6587 causeOf TRAF2,functions downstream
R5010 T6589 T6590 themeOf TRAF2,associated
R5011 T6589 T6591 themeOf TRAF2,associated
R5012 T6592 T6590 themeOf cIAP1,associated
R5013 T6592 T6597 causeOf cIAP1,role
R5014 T6592 T6596 causeOf cIAP1,role
R5015 T6593 T6591 themeOf cIAP2,associated
R5016 T6593 T6594 causeOf cIAP2,role
R5017 T6593 T6595 causeOf cIAP2,role
R5018 T6598 T6597 themeOf recruitment,role
R5019 T6598 T6594 themeOf recruitment,role
R5020 T6599 T6596 themeOf recruitment,role
R5021 T6599 T6595 themeOf recruitment,role
R5022 T6600 T6598 themeOf HOIP,recruitment
R5023 T6600 T6599 themeOf HOIP,recruitment
R5024 T6601 T6598 themeOf TNFR1,recruitment
R5025 T6602 T6599 themeOf CD40,recruitment
R5026 T6603 T6606 themeOf association,altered
R5027 T6604 T6603 themeOf HOIP,association
R5028 T6605 T6603 themeOf CD40,association
R5029 T6608 T6609 themeOf cIAP1,associated
R5030 T6609 T6607 themeOf associated,reduced
R5031 T6612 T6611 themeOf decrease,resulted
R5032 T6613 T6612 themeOf HOIP,decrease
R5033 T6613 T6616 themeOf HOIP,increase
R5034 T6613 T6614 themeOf HOIP,recovered
R5035 T6613 T6617 themeOf HOIP,recognized
R5036 T6615 T6614 themeOf CD40,recovered
R5037 T6616 T6610 themeOf increase,resulted
R5038 T6619 T6618 themeOf HOIP,alter
R5039 T6621 T6622 themeOf CD40,associated
R5040 T6623 T6620 themeOf HOIP,alters
R5041 T6623 T6622 themeOf HOIP,associated
R5042 T6624 T6626 causeOf cIAP,influence
R5043 T6624 T6625 causeOf cIAP,influence
R5044 T6627 T6626 themeOf recruitment,influence
R5045 T6628 T6625 themeOf post-translational modification,influence
R5046 T6629 T6630 themeOf CD40,associated
R5047 T6631 T6627 themeOf HOIP,recruitment
R5048 T6631 T6628 themeOf HOIP,post-translational modification
R5049 T6631 T6630 themeOf HOIP,associated
R5050 T6632 T6633 causeOf HOIP,responsible
R5051 T6634 T6633 themeOf recruitment,responsible
R5052 T6635 T6634 themeOf CD40,recruitment
R5053 T6636 T6637 themeOf HOIP,deficient
R5054 T6638 T6639 themeOf HOIP,reconstituted
R5055 T6646 T6655 themeOf TRAF2,association
R5056 T6647 T6657 themeOf TRAF3,association
R5057 T6648 T6656 themeOf cIAP1,association
R5058 T6651 T6654 causeOf HOIP,required
R5059 T6651 T6653 causeOf HOIP,required
R5060 T6651 T6652 causeOf HOIP,required
R5061 T6655 T6654 themeOf association,required
R5062 T6656 T6652 themeOf association,required
R5063 T6657 T6653 themeOf association,required
R5064 T6658 T6655 themeOf CD40,association
R5065 T6658 T6657 themeOf CD40,association
R5066 T6658 T6656 themeOf CD40,association
R5067 T6663 T6664 themeOf HOIP,deficient
R5068 T6669 T6670 themeOf HOIP,reconstituted
R5069 T6672 T6673 themeOf HOIP,expression
R5070 T6673 T6671 themeOf expression,absence
R5071 T6682 T6681 themeOf IKKγ,expressing
R5072 T6683 T6686 themeOf recruitment,requires
R5073 T6684 T6683 themeOf IKKγ,recruitment
R5074 T6685 T6683 themeOf CD40,recruitment
R5075 T6687 T6686 causeOf HOIP,requires
R5076 T6690 T6691 themeOf CD40,associated
R5077 T6692 T6691 themeOf IKKγ,associated
R5078 T6693 T6694 themeOf CD40,associated
R5079 T6695 T6694 themeOf IKKγ,associated
R5080 T6695 T6696 themeOf IKKγ,phosphorylation
R5081 T6697 T6698 causeOf HOIP,required
R5082 T6699 T6698 themeOf association,required
R5083 T6699 T6702 causeOf association,coupled
R5084 T6700 T6699 themeOf IKKγ,association
R5085 T6701 T6699 themeOf CD40,association
R5086 T6703 T6702 themeOf post-translational modifications,coupled
R5087 T6704 T6703 themeOf IKKγ,post-translational modifications
R13169 T16768 T16769 themeOf HOIP,deficient
R13170 T16771 T16770 themeOf recruitment,reduces
R13171 T16772 T16771 themeOf cIAP1,recruitment
R13172 T16773 T16771 themeOf CD40,recruitment
R13173 T16775 T16776 themeOf HOIP,recruitment
R13174 T16776 T16774 themeOf recruitment,modify
R13175 T16782 T16783 themeOf HOIP,deficient
R13176 T16793 T16794 themeOf HOIP,expression
R13177 T16796 T16797 themeOf HOIP,deficient
R13178 T16798 T16799 causeOf HOIP,dependent
R13179 T16800 T16799 themeOf recruitment,dependent
R13180 T16801 T16800 themeOf IKKγ,recruitment
R13181 T16802 T16800 themeOf CD40,recruitment
R13182 T16803 T16804 themeOf HOIP,deficient

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T8616 85-89 Protein denotes CD40
T8617 234-238 Protein denotes CD40
T8618 334-338 Protein denotes CD40
T8619 362-367 Protein denotes TRAF2
T8620 431-436 Protein denotes TRAF2
T8621 317-326 Binding denotes recruited
T8622 477-482 Protein denotes TRAF2
T8623 503-508 Protein denotes cIAP1
T8624 513-518 Protein denotes cIAP2
T8625 553-557 Protein denotes HOIP
T8626 561-566 Protein denotes TNFR1
T8627 538-549 Binding denotes recruitment
T8628 644-648 Protein denotes CD40
T8629 720-724 Protein denotes cIAP
T8630 619-630 Binding denotes association
T8631 707-716 Negative_regulation denotes inhibitor
T8632 857-869 Protein denotes SMAC peptide
T8633 905-910 Protein denotes cIAP1
T8634 931-935 Protein denotes CD40
T8635 984-988 Protein denotes CD40
T8636 911-921 Binding denotes associated
T8637 883-890 Negative_regulation denotes reduced
T8638 1147-1151 Protein denotes CD40
T8639 1254-1272 Protein denotes anti-HOIP antibody
T8640 1152-1171 Binding denotes immunoprecipitation
T8641 1240-1250 Binding denotes recognized
T8642 1088-1096 Negative_regulation denotes decrease
T8643 1306-1318 Protein denotes SMAC peptide
T8644 1487-1491 Protein denotes CD40
T8645 1612-1625 Protein denotes cIAP proteins
T8646 1697-1701 Protein denotes CD40
T8647 4281-4285 Protein denotes CD40
T8648 4309-4313 Protein denotes CD40
T8649 4419-4423 Protein denotes CD40
T8650 4507-4512 Protein denotes TRAF2
T8651 4514-4519 Protein denotes TRAF3
T8652 4521-4527 Protein denotes IKKα/β
T8653 4558-4563 Protein denotes TRAF2
T8654 4565-4570 Protein denotes TRAF3
T8655 4576-4581 Protein denotes cIAP1
T8656 4585-4589 Protein denotes CD40
T8657 4765-4769 Protein denotes CD40
T8658 4730-4741 Binding denotes association
T8659 4730-4741 Binding denotes association
T8660 4730-4741 Binding denotes association
T8661 4784-4799 Protein denotes IKKα/β and IKKγ
T8662 4823-4827 Protein denotes CD40
T8663 4809-4819 Gene_expression denotes detectable
T8664 4809-4819 Gene_expression denotes detectable
T8665 4911-4934 Protein denotes IKKα/β and IKKγ in CD40
T8666 5090-5093 Protein denotes IKK
T8667 5158-5162 Protein denotes HOIP
T8668 5094-5105 Binding denotes recruitment
T8669 5163-5173 Gene_expression denotes expression
T8670 5147-5154 Negative_regulation denotes absence
T8671 5240-5245 Protein denotes NF-κB
T8672 5272-5276 Protein denotes CD40
T8673 5221-5232 Binding denotes recruitment
T8674 5341-5345 Protein denotes IKKγ
T8675 5357-5361 Protein denotes CD40
T8676 5520-5524 Protein denotes IKKγ
T8677 5648-5658 Protein denotes mouse IKKγ
T8678 5677-5681 Protein denotes CD40
T8679 6049-6053 Protein denotes IKKγ
T8680 6057-6061 Protein denotes CD40
T8681 6071-6075 Protein denotes HOIP
T8682 6034-6045 Binding denotes recruitment
T8683 6062-6070 Positive_regulation denotes requires
T8684 6157-6161 Protein denotes CD40
T8685 6222-6240 Protein denotes lambda phosphatase
T8686 6363-6367 Protein denotes CD40
T8687 6379-6383 Protein denotes IKKγ
T8688 6347-6354 Negative_regulation denotes reduced
T8689 6596-6600 Protein denotes CD40
T8690 6612-6616 Protein denotes IKKγ
T8691 6601-6611 Binding denotes associated
T8692 6678-6693 Phosphorylation denotes phosphorylation
T8693 6772-6776 Protein denotes IKKγ
T8694 6782-6786 Protein denotes CD40
T8695 6757-6768 Binding denotes association
T17868 1763-1766 Protein denotes IKK
T17869 1786-1790 Protein denotes CD40
T17870 1767-1778 Binding denotes recruitment
T17871 1897-1902 Protein denotes cIAP1
T17872 1906-1910 Protein denotes CD40
T17873 1882-1893 Binding denotes recruitment
T17874 1874-1881 Negative_regulation denotes reduces
T17875 2288-2297 Protein denotes anti-CD40
T17876 2304-2328 Protein denotes isotype control antibody
T17877 2537-2542 Protein denotes cIAP1
T17878 2544-2549 Protein denotes TRAF2
T17879 2551-2556 Protein denotes TRAF3
T17880 2683-2687 Protein denotes CD40
T17881 2941-2959 Protein denotes anti-CD40 antibody
T17882 2997-3001 Protein denotes CD40
T17883 3003-3008 Protein denotes TRAF2
T17884 3010-3015 Protein denotes TRAF3
T17885 3017-3022 Protein denotes cIAP1
T17886 3024-3028 Protein denotes HOIP
T17887 3030-3036 Protein denotes IKKα/β
T17888 2876-2894 Binding denotes immunoprecipitated
T17889 3115-3127 Protein denotes IKK proteins
T17890 3133-3137 Protein denotes CD40
T17891 3096-3111 Binding denotes coprecipitation
T17892 3083-3091 Positive_regulation denotes required
T17893 3342-3376 Protein denotes HOIP-dependent recruitment of IKKγ
T17894 3380-3384 Protein denotes CD40
T17895 3541-3545 Protein denotes IKKγ
T17896 3579-3583 Protein denotes IKKγ
T17897 3777-3783 Protein denotes BP tag
T17898 3785-3789 Protein denotes IKKγ
T17899 3808-3813 Protein denotes TRAF2
T17900 3819-3831 Protein denotes anti-CD40 IP
T17901 3867-3880 Protein denotes λ phosphatase
T17902 4073-4078 Protein denotes TRAF3
R6724 T8625 T8627 themeOf HOIP,recruitment
R6744 T8626 T8627 themeOf TNFR1,recruitment
R6745 T8628 T8630 themeOf CD40,association
R6746 T8629 T8631 themeOf cIAP,inhibitor
R6747 T8633 T8636 themeOf cIAP1,associated
R6750 T8634 T8636 themeOf CD40,associated
R6751 T8618 T8621 themeOf CD40,recruited
R6752 T8636 T8637 themeOf associated,reduced
R6753 T8638 T8640 themeOf CD40,immunoprecipitation
R6755 T8639 T8641 themeOf anti-HOIP antibody,recognized
R6759 T8640 T8642 themeOf immunoprecipitation,decrease
R6761 T8653 T8658 themeOf TRAF2,association
R6775 T8654 T8659 themeOf TRAF3,association
R6781 T8655 T8660 themeOf cIAP1,association
R6786 T8657 T8658 themeOf CD40,association
R6790 T8657 T8659 themeOf CD40,association
R6792 T8657 T8660 themeOf CD40,association
R6793 T8661 T8663 themeOf IKKα/β and IKKγ,detectable
R6794 T8662 T8664 themeOf CD40,detectable
R6797 T8666 T8668 themeOf IKK,recruitment
R6802 T8667 T8669 themeOf HOIP,expression
R6803 T8669 T8670 themeOf expression,absence
R6804 T8671 T8673 themeOf NF-κB,recruitment
R6809 T8672 T8673 themeOf CD40,recruitment
R6812 T8679 T8682 themeOf IKKγ,recruitment
R6815 T8680 T8682 themeOf CD40,recruitment
R6817 T8681 T8683 themeOf HOIP,requires
R6819 T8682 T8683 causeOf recruitment,requires
R6820 T8687 T8688 themeOf IKKγ,reduced
R6824 T8689 T8691 themeOf CD40,associated
R6828 T8690 T8691 themeOf IKKγ,associated
R6831 T8690 T8692 themeOf IKKγ,phosphorylation
R6832 T8693 T8695 themeOf IKKγ,association
R6838 T8694 T8695 themeOf CD40,association
R14086 T17868 T17870 themeOf IKK,recruitment
R14087 T17869 T17870 themeOf CD40,recruitment
R14088 T17871 T17873 themeOf cIAP1,recruitment
R14089 T17872 T17873 themeOf CD40,recruitment
R14090 T17873 T17874 themeOf recruitment,reduces
R14091 T17881 T17888 themeOf anti-CD40 antibody,immunoprecipitated
R14092 T17889 T17891 themeOf IKK proteins,coprecipitation
R14093 T17890 T17891 themeOf CD40,coprecipitation
R14094 T17891 T17892 themeOf coprecipitation,required

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T8589 58-62 Protein denotes CD40
T8590 85-89 Protein denotes CD40
T8591 142-146 Protein denotes HOIP
T8592 147-156 Negative_regulation denotes deficient
T8593 178-182 Protein denotes HOIP
T8594 309-313 Protein denotes HOIP
T8595 317-326 Binding denotes recruited
T8596 362-367 Protein denotes TRAF2
T8597 368-377 Regulation denotes dependent
T8598 402-406 Protein denotes HOIP
T8599 407-427 Regulation denotes functions downstream true
T8600 431-436 Protein denotes TRAF2
T8601 477-482 Protein denotes TRAF2
T8602 483-493 Binding denotes associated
T8603 483-493 Binding denotes associated
T8604 503-508 Protein denotes cIAP1
T8605 513-518 Protein denotes cIAP2
T8606 526-530 Regulation denotes role
T8607 526-530 Regulation denotes role
T8608 526-530 Regulation denotes role
T8609 526-530 Regulation denotes role
T8610 538-549 Binding denotes recruitment
T8611 538-549 Binding denotes recruitment
T8612 553-557 Protein denotes HOIP
T8696 561-566 Protein denotes TNFR1
T8697 571-575 Protein denotes CD40
T8698 619-630 Binding denotes association
T8699 634-638 Protein denotes HOIP
T8700 644-648 Protein denotes CD40
T8701 669-676 Regulation denotes altered true
T8702 883-890 Negative_regulation denotes reduced
T8703 905-910 Protein denotes cIAP1
T8704 911-921 Binding denotes associated
T8705 1050-1058 Positive_regulation denotes resulted
T8706 1050-1058 Positive_regulation denotes resulted
T8707 1088-1096 Negative_regulation denotes decrease
T8708 1124-1128 Protein denotes HOIP
T8709 1134-1143 Binding denotes recovered
T8710 1147-1151 Protein denotes CD40
T8711 1196-1204 Positive_regulation denotes increase
T8712 1240-1250 Binding denotes recognized
T8713 1327-1332 Regulation denotes alter true
T8714 1367-1371 Protein denotes HOIP
T8715 1457-1463 Regulation denotes alters
T8716 1487-1491 Protein denotes CD40
T8717 1492-1502 Binding denotes associated
T8718 1503-1507 Protein denotes HOIP
T8719 1612-1616 Protein denotes cIAP
T8720 1626-1635 Regulation denotes influence
T8721 1626-1635 Regulation denotes influence
T8722 1640-1651 Binding denotes recruitment
T8723 1656-1687 Protein_modification denotes post-translational modification
T8724 1697-1701 Protein denotes CD40
T8725 1702-1712 Binding denotes associated
T8726 1713-1717 Protein denotes HOIP
T8727 4201-4205 Protein denotes HOIP
T8728 4209-4220 Regulation denotes responsible true
T8729 4229-4240 Binding denotes recruitment
T8730 4281-4285 Protein denotes CD40
T8731 4339-4343 Protein denotes HOIP
T8732 4344-4353 Negative_regulation denotes deficient
T8733 4358-4362 Protein denotes HOIP
T8734 4363-4376 Positive_regulation denotes reconstituted
T8735 4491-4495 Protein denotes HOIP
T8736 4507-4512 Protein denotes TRAF2
T8737 4514-4519 Protein denotes TRAF3
T8738 4521-4525 Protein denotes IKKα
T8739 4526-4527 Protein denotes β
T8740 4533-4537 Protein denotes IKKγ
T8741 4558-4563 Protein denotes TRAF2
T8742 4565-4570 Protein denotes TRAF3
T8743 4576-4581 Protein denotes cIAP1
T8744 4585-4589 Protein denotes CD40
T8745 4614-4618 Protein denotes HOIP
T8746 4701-4705 Protein denotes HOIP
T8747 4713-4721 Positive_regulation denotes required true
T8748 4713-4721 Positive_regulation denotes required true
T8749 4713-4721 Positive_regulation denotes required true
T8750 4730-4741 Binding denotes association
T8751 4730-4741 Binding denotes association
T8752 4730-4741 Binding denotes association
T8753 4765-4769 Protein denotes CD40
T8754 4784-4788 Protein denotes IKKα
T8755 4789-4790 Protein denotes β
T8756 4795-4799 Protein denotes IKKγ
T8757 4823-4827 Protein denotes CD40
T8758 4862-4866 Protein denotes HOIP
T8759 4867-4876 Negative_regulation denotes deficient
T8760 4911-4915 Protein denotes IKKα
T8761 4916-4917 Protein denotes β
T8762 4922-4926 Protein denotes IKKγ
T8763 4930-4934 Protein denotes CD40
T8764 4959-4963 Protein denotes HOIP
T8765 4964-4977 Positive_regulation denotes reconstituted
T8766 5147-5154 Negative_regulation denotes absence
T8767 5158-5162 Protein denotes HOIP
T8768 5163-5173 Gene_expression denotes expression
T8769 5200-5204 Protein denotes HOIP
T8770 5341-5345 Protein denotes IKKγ
T8771 5357-5361 Protein denotes CD40
T8772 5520-5524 Protein denotes IKKγ
T8773 5654-5658 Protein denotes IKKγ
T8774 5677-5681 Protein denotes CD40
T8775 5919-5923 Protein denotes IKKγ
T8776 5988-5998 Gene_expression denotes expressing
T8777 6014-6018 Protein denotes IKKγ
T8778 6034-6045 Binding denotes recruitment
T8779 6049-6053 Protein denotes IKKγ
T8780 6057-6061 Protein denotes CD40
T8781 6062-6070 Positive_regulation denotes requires
T8782 6071-6075 Protein denotes HOIP
T8783 6149-6153 Protein denotes IKKγ
T8784 6157-6161 Protein denotes CD40
T8785 6363-6367 Protein denotes CD40
T8786 6368-6378 Binding denotes associated
T8787 6379-6383 Protein denotes IKKγ
T8788 6596-6600 Protein denotes CD40
T8789 6601-6611 Binding denotes associated
T8790 6612-6616 Protein denotes IKKγ
T8791 6678-6693 Phosphorylation denotes phosphorylation
T8792 6732-6736 Protein denotes HOIP
T8793 6740-6748 Positive_regulation denotes required
T8794 6757-6768 Binding denotes association
T8795 6772-6776 Protein denotes IKKγ
T8796 6782-6786 Protein denotes CD40
T8797 6819-6826 Positive_regulation denotes coupled
T8798 6830-6862 Protein_modification denotes post-translational modifications
T8799 6866-6870 Protein denotes IKKγ
T17903 1825-1829 Protein denotes HOIP
T17904 1830-1839 Negative_regulation denotes deficient
T17905 1874-1881 Negative_regulation denotes reduces
T17906 1882-1893 Binding denotes recruitment
T17907 1897-1902 Protein denotes cIAP1
T17908 1906-1910 Protein denotes CD40
T17909 1919-1925 Regulation denotes modify true
T17910 1926-1930 Protein denotes HOIP
T17911 1931-1942 Binding denotes recruitment
T17912 2537-2542 Protein denotes cIAP1
T17913 2544-2549 Protein denotes TRAF2
T17914 2551-2556 Protein denotes TRAF3
T17915 2562-2566 Protein denotes HOIP
T17916 2683-2687 Protein denotes CD40
T17917 2758-2762 Protein denotes HOIP
T17918 2763-2772 Negative_regulation denotes deficient
T17919 2861-2865 Protein denotes HOIP
T17920 2997-3001 Protein denotes CD40
T17921 3003-3008 Protein denotes TRAF2
T17922 3010-3015 Protein denotes TRAF3
T17923 3017-3022 Protein denotes cIAP1
T17924 3024-3028 Protein denotes HOIP
T17925 3030-3034 Protein denotes IKKα
T17926 3035-3036 Protein denotes β
T17927 3042-3046 Protein denotes IKKγ
T17928 3063-3067 Protein denotes HOIP
T17929 3068-3078 Gene_expression denotes expression
T17930 3133-3137 Protein denotes CD40
T17931 3296-3300 Protein denotes HOIP
T17932 3301-3310 Negative_regulation denotes deficient
T17933 3342-3346 Protein denotes HOIP
T17934 3347-3356 Regulation denotes dependent true
T17935 3357-3368 Binding denotes recruitment
T17936 3372-3376 Protein denotes IKKγ
T17937 3380-3384 Protein denotes CD40
T17938 3402-3406 Protein denotes HOIP
T17939 3407-3416 Negative_regulation denotes deficient
T17940 3418-3422 Protein denotes HOIP
T17941 3541-3545 Protein denotes IKKγ
T17942 3570-3574 Protein denotes pMIP
T17943 3579-3583 Protein denotes IKKγ
T17944 3785-3789 Protein denotes IKKγ
T17945 3808-3813 Protein denotes TRAF2
T17946 4073-4078 Protein denotes TRAF3
T17947 4083-4087 Protein denotes HOIP
R6722 T8591 T8592 themeOf HOIP,deficient
R6725 T8594 T8595 themeOf HOIP,recruited
R6726 T8595 T8597 themeOf recruited,dependent
R6727 T8596 T8597 causeOf TRAF2,dependent
R6728 T8598 T8599 themeOf HOIP,functions downstream
R6729 T8600 T8599 causeOf TRAF2,functions downstream
R6730 T8601 T8602 themeOf TRAF2,associated
R6731 T8601 T8603 themeOf TRAF2,associated
R6732 T8604 T8602 themeOf cIAP1,associated
R6733 T8604 T8609 causeOf cIAP1,role
R6734 T8604 T8608 causeOf cIAP1,role
R6735 T8605 T8603 themeOf cIAP2,associated
R6736 T8605 T8606 causeOf cIAP2,role
R6737 T8605 T8607 causeOf cIAP2,role
R6738 T8610 T8609 themeOf recruitment,role
R6739 T8610 T8606 themeOf recruitment,role
R6740 T8611 T8608 themeOf recruitment,role
R6741 T8611 T8607 themeOf recruitment,role
R6742 T8612 T8610 themeOf HOIP,recruitment
R6743 T8612 T8611 themeOf HOIP,recruitment
R6754 T8696 T8610 themeOf TNFR1,recruitment
R6756 T8697 T8611 themeOf CD40,recruitment
R6757 T8698 T8701 themeOf association,altered
R6758 T8699 T8698 themeOf HOIP,association
R6760 T8700 T8698 themeOf CD40,association
R6762 T8703 T8704 themeOf cIAP1,associated
R6763 T8704 T8702 themeOf associated,reduced
R6764 T8707 T8706 themeOf decrease,resulted
R6765 T8708 T8707 themeOf HOIP,decrease
R6766 T8708 T8711 themeOf HOIP,increase
R6767 T8708 T8709 themeOf HOIP,recovered
R6768 T8708 T8712 themeOf HOIP,recognized
R6769 T8710 T8709 themeOf CD40,recovered
R6770 T8711 T8705 themeOf increase,resulted
R6771 T8714 T8713 themeOf HOIP,alter
R6772 T8716 T8717 themeOf CD40,associated
R6773 T8718 T8715 themeOf HOIP,alters
R6774 T8718 T8717 themeOf HOIP,associated
R6776 T8719 T8721 causeOf cIAP,influence
R6777 T8719 T8720 causeOf cIAP,influence
R6778 T8722 T8721 themeOf recruitment,influence
R6779 T8723 T8720 themeOf post-translational modification,influence
R6780 T8724 T8725 themeOf CD40,associated
R6782 T8726 T8722 themeOf HOIP,recruitment
R6783 T8726 T8723 themeOf HOIP,post-translational modification
R6784 T8726 T8725 themeOf HOIP,associated
R6785 T8727 T8728 causeOf HOIP,responsible
R6787 T8729 T8728 themeOf recruitment,responsible
R6788 T8730 T8729 themeOf CD40,recruitment
R6789 T8731 T8732 themeOf HOIP,deficient
R6791 T8733 T8734 themeOf HOIP,reconstituted
R6795 T8741 T8750 themeOf TRAF2,association
R6796 T8742 T8752 themeOf TRAF3,association
R6798 T8743 T8751 themeOf cIAP1,association
R6799 T8746 T8749 causeOf HOIP,required
R6800 T8746 T8748 causeOf HOIP,required
R6801 T8746 T8747 causeOf HOIP,required
R6805 T8750 T8749 themeOf association,required
R6806 T8751 T8747 themeOf association,required
R6807 T8752 T8748 themeOf association,required
R6808 T8753 T8750 themeOf CD40,association
R6810 T8753 T8752 themeOf CD40,association
R6811 T8753 T8751 themeOf CD40,association
R6813 T8758 T8759 themeOf HOIP,deficient
R6814 T8764 T8765 themeOf HOIP,reconstituted
R6816 T8767 T8768 themeOf HOIP,expression
R6818 T8768 T8766 themeOf expression,absence
R6821 T8777 T8776 themeOf IKKγ,expressing
R6822 T8778 T8781 themeOf recruitment,requires
R6823 T8779 T8778 themeOf IKKγ,recruitment
R6825 T8780 T8778 themeOf CD40,recruitment
R6826 T8782 T8781 causeOf HOIP,requires
R6827 T8785 T8786 themeOf CD40,associated
R6829 T8787 T8786 themeOf IKKγ,associated
R6830 T8788 T8789 themeOf CD40,associated
R6833 T8790 T8789 themeOf IKKγ,associated
R6834 T8790 T8791 themeOf IKKγ,phosphorylation
R6835 T8792 T8793 causeOf HOIP,required
R6836 T8794 T8793 themeOf association,required
R6837 T8794 T8797 causeOf association,coupled
R6839 T8795 T8794 themeOf IKKγ,association
R6840 T8796 T8794 themeOf CD40,association
R6841 T8798 T8797 themeOf post-translational modifications,coupled
R6842 T8799 T8798 themeOf IKKγ,post-translational modifications
R14095 T17903 T17904 themeOf HOIP,deficient
R14096 T17906 T17905 themeOf recruitment,reduces
R14097 T17907 T17906 themeOf cIAP1,recruitment
R14098 T17908 T17906 themeOf CD40,recruitment
R14099 T17910 T17911 themeOf HOIP,recruitment
R14100 T17911 T17909 themeOf recruitment,modify
R14101 T17917 T17918 themeOf HOIP,deficient
R14102 T17928 T17929 themeOf HOIP,expression
R14103 T17931 T17932 themeOf HOIP,deficient
R14104 T17933 T17934 causeOf HOIP,dependent
R14105 T17935 T17934 themeOf recruitment,dependent
R14106 T17936 T17935 themeOf IKKγ,recruitment
R14107 T17937 T17935 themeOf CD40,recruitment
R14108 T17938 T17939 themeOf HOIP,deficient

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T8182 1232-1239 Anaphor denotes species
T8183 1124-1128 Antecedent denotes HOIP
T8184 4745-4759 Anaphor denotes these proteins
T8185 4558-4563 Antecedent denotes TRAF2
T8186 4565-4570 Antecedent denotes TRAF3
T8187 4576-4581 Antecedent denotes cIAP1
T8188 6805-6815 Anaphor denotes this event
T8189 6757-6768 Antecedent denotes association
R6476 T8182 T8183 boundBy species,HOIP
R6478 T8184 T8185 boundBy these proteins,TRAF2
R6479 T8184 T8186 boundBy these proteins,TRAF3
R6480 T8184 T8187 boundBy these proteins,cIAP1
R6482 T8188 T8189 boundBy this event,association

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T7484 53-57 IN denotes with
T7485 58-62 NN denotes CD40
T7486 63-66 DT denotes The
T7487 67-73 JJ denotes marked
T7488 74-81 NN denotes defects
T7489 82-84 IN denotes in
T7490 85-98 JJ denotes CD40-mediated
T7491 99-103 NN denotes cell
T7492 104-114 NN denotes activation
T7493 115-118 CC denotes and
T7494 119-128 NN denotes signaling
T7495 129-138 VB denotes displayed
T7496 139-141 IN denotes by
T7497 142-156 JJ denotes HOIP-deficient
T7498 157-162 NN denotes cells
T7499 163-172 VB denotes suggested
T7500 173-177 IN denotes that
T7501 178-182 NN denotes HOIP
T7502 183-191 VB denotes mediates
T7503 192-203 NN denotes recruitment
T7504 204-206 IN denotes of
T7505 207-215 JJ denotes critical
T7506 216-226 NN denotes components
T7507 227-229 IN denotes of
T7508 230-233 DT denotes the
T7509 234-238 NN denotes CD40
T7510 239-248 NN denotes signaling
T7511 249-258 NN denotes apparatus
T7512 259-261 TO denotes to
T7513 262-265 DT denotes the
T7514 266-274 NN denotes receptor
T7515 276-286 RB denotes Previously
T7516 286-287 -COMMA- denotes ,
T7517 288-290 PRP denotes we
T7518 291-303 VB denotes demonstrated
T7519 304-308 IN denotes that
T7520 309-313 NN denotes HOIP
T7521 314-316 VB denotes is
T7522 317-326 VB denotes recruited
T7523 327-329 TO denotes to
T7524 330-333 DT denotes the
T7525 334-338 NN denotes CD40
T7526 339-348 NN denotes signaling
T7527 349-356 NN denotes complex
T7528 357-359 IN denotes in
T7529 360-361 DT denotes a
T7530 362-377 JJ denotes TRAF2-dependent
T7531 378-384 NN denotes manner
T7532 384-385 -COMMA- denotes ,
T7533 386-396 VB denotes suggesting
T7534 397-401 IN denotes that
T7535 402-406 NN denotes HOIP
T7536 407-416 NN denotes functions
T7537 417-427 JJ denotes downstream
T7538 428-430 IN denotes of
T7539 431-436 NN denotes TRAF2
T7540 437-438 -LRB- denotes [
T7541 438-439 CD denotes 6
T7542 439-440 -RRB- denotes ]
T7543 442-449 NN denotes Studies
T7544 450-452 IN denotes by
T7545 453-459 NN denotes others
T7546 460-467 VB denotes suggest
T7547 468-472 IN denotes that
T7548 473-476 DT denotes the
T7549 477-493 JJ denotes TRAF2-associated
T7550 494-502 NN denotes proteins
T7551 503-508 NN denotes cIAP1
T7552 509-512 CC denotes and
T7553 513-518 NN denotes cIAP2
T7554 519-523 VB denotes play
T7555 524-525 DT denotes a
T7556 526-530 NN denotes role
T7557 531-533 IN denotes in
T7558 534-537 DT denotes the
T7559 538-549 NN denotes recruitment
T7560 550-552 IN denotes of
T7561 553-557 NN denotes HOIP
T7562 558-560 TO denotes to
T7563 561-566 NN denotes TNFR1
T7564 567-570 CC denotes and
T7565 571-575 NN denotes CD40
T7566 576-577 -LRB- denotes [
T7567 577-579 CD denotes 14
T7568 579-580 -RRB- denotes ]
T7569 582-591 RB denotes Therefore
T7570 591-592 -COMMA- denotes ,
T7571 593-595 PRP denotes we
T7572 596-606 VB denotes determined
T7573 607-614 IN denotes whether
T7574 615-618 DT denotes the
T7575 619-630 NN denotes association
T7576 631-633 IN denotes of
T7577 634-638 NN denotes HOIP
T7578 639-643 IN denotes with
T7579 644-648 NN denotes CD40
T7580 649-651 IN denotes in
T7581 652-658 NN denotes A20.2J
T7582 659-664 NN denotes cells
T7583 665-668 VB denotes was
T7584 669-676 VB denotes altered
T7585 677-679 IN denotes by
T7586 680-689 NN denotes treatment
T7587 690-692 IN denotes of
T7588 693-698 NN denotes cells
T7589 699-703 IN denotes with
T7590 704-706 DT denotes an
T7591 707-716 NN denotes inhibitor
T7592 717-719 IN denotes of
T7593 720-724 NN denotes cIAP
T7594 725-733 NN denotes activity
T7595 733-734 -COMMA- denotes ,
T7596 735-736 DT denotes a
T7597 737-755 JJ denotes membrane-permeable
T7598 756-763 NN denotes peptide
T7599 764-771 VB denotes derived
T7600 772-776 IN denotes from
T7601 777-780 DT denotes the
T7602 781-790 NN denotes apoptosis
T7603 791-800 NN denotes regulator
T7604 801-805 NN denotes SMAC
T7605 806-807 -LRB- denotes [
T7606 807-809 CD denotes 15
T7607 809-810 -RRB- denotes ]
T7608 812-814 PRP denotes We
T7609 815-820 VB denotes found
T7610 821-825 IN denotes that
T7611 826-838 NN denotes pretreatment
T7612 839-841 IN denotes of
T7613 842-847 NN denotes cells
T7614 848-852 IN denotes with
T7615 853-856 DT denotes the
T7616 857-861 NN denotes SMAC
T7617 862-869 NN denotes peptide
T7618 870-882 RB denotes dramatically
T7619 883-890 VB denotes reduced
T7620 891-894 DT denotes the
T7621 895-901 NN denotes amount
T7622 902-904 IN denotes of
T7623 905-910 NN denotes cIAP1
T7624 911-921 VB denotes associated
T7625 922-926 IN denotes with
T7626 927-930 DT denotes the
T7627 931-935 NN denotes CD40
T7628 936-945 NN denotes signaling
T7629 946-953 NN denotes complex
T7630 954-956 IN denotes in
T7631 957-962 NN denotes cells
T7632 963-973 VB denotes stimulated
T7633 974-978 IN denotes with
T7634 979-988 JJ denotes anti-CD40
T7635 989-1004 JJ denotes antibody-coated
T7636 1005-1010 NN denotes beads
T7637 1011-1012 -LRB- denotes (
T7638 1012-1016 NNP denotes Fig.
T7639 1017-1019 NN denotes 5A
T7640 1019-1020 -RRB- denotes )
T7641 1022-1026 NN denotes SMAC
T7642 1027-1034 NN denotes peptide
T7643 1035-1044 NN denotes treatment
T7644 1045-1049 RB denotes also
T7645 1050-1058 VB denotes resulted
T7646 1059-1061 IN denotes in
T7647 1062-1063 DT denotes a
T7648 1064-1070 JJ denotes slight
T7649 1071-1074 CC denotes but
T7650 1075-1087 JJ denotes reproducible
T7651 1088-1096 NN denotes decrease
T7652 1097-1099 IN denotes in
T7653 1100-1103 DT denotes the
T7654 1104-1110 NN denotes amount
T7655 1111-1113 IN denotes of
T7656 1114-1117 DT denotes the
T7657 1118-1123 JJ denotes major
T7658 1124-1128 NN denotes HOIP
T7659 1129-1133 NN denotes form
T7660 1134-1143 VB denotes recovered
T7661 1144-1146 IN denotes by
T7662 1147-1151 NN denotes CD40
T7663 1152-1171 NN denotes immunoprecipitation
T7664 1171-1172 -COMMA- denotes ,
T7665 1173-1178 IN denotes along
T7666 1179-1183 IN denotes with
T7667 1184-1186 DT denotes an
T7668 1187-1195 JJ denotes apparent
T7669 1196-1204 NN denotes increase
T7670 1205-1207 IN denotes in
T7671 1208-1214 JJ denotes higher
T7672 1215-1224 JJ denotes molecular
T7673 1225-1231 NN denotes weight
T7674 1232-1239 NN denotes species
T7675 1240-1250 VB denotes recognized
T7676 1251-1253 IN denotes by
T7677 1254-1263 JJ denotes anti-HOIP
T7678 1264-1272 NN denotes antibody
T7679 1274-1276 IN denotes In
T7680 1277-1285 NN denotes contrast
T7681 1285-1286 -COMMA- denotes ,
T7682 1287-1296 NN denotes treatment
T7683 1297-1301 IN denotes with
T7684 1302-1305 DT denotes the
T7685 1306-1310 NN denotes SMAC
T7686 1311-1318 NN denotes peptide
T7687 1319-1322 VB denotes did
T7688 1323-1326 RB denotes not
T7689 1327-1332 VB denotes alter
T7690 1333-1336 DT denotes the
T7691 1337-1343 NN denotes amount
T7692 1344-1346 CC denotes or
T7693 1347-1356 JJ denotes molecular
T7694 1357-1363 NN denotes weight
T7695 1364-1366 IN denotes of
T7696 1367-1371 NN denotes HOIP
T7697 1372-1379 JJ denotes present
T7698 1380-1382 IN denotes in
T7699 1383-1387 NN denotes cell
T7700 1388-1395 NN denotes lysates
T7701 1397-1402 DT denotes These
T7702 1403-1407 NN denotes data
T7703 1408-1415 VB denotes suggest
T7704 1416-1420 IN denotes that
T7705 1421-1425 NN denotes SMAC
T7706 1426-1433 NN denotes peptide
T7707 1434-1443 NN denotes treatment
T7708 1444-1456 RB denotes specifically
T7709 1457-1463 VB denotes alters
T7710 1464-1467 DT denotes the
T7711 1468-1483 NN denotes characteristics
T7712 1484-1486 IN denotes of
T7713 1487-1502 JJ denotes CD40-associated
T7714 1503-1507 NN denotes HOIP
T7715 1508-1514 RB denotes rather
T7716 1515-1519 IN denotes than
T7717 1520-1523 DT denotes the
T7718 1524-1530 JJ denotes entire
T7719 1531-1539 JJ denotes cellular
T7720 1540-1544 NN denotes pool
T7721 1545-1547 IN denotes of
T7722 1548-1552 DT denotes this
T7723 1553-1560 NN denotes protein
T7724 1562-1570 RB denotes Together
T7725 1570-1571 -COMMA- denotes ,
T7726 1572-1577 DT denotes these
T7727 1578-1585 NN denotes results
T7728 1586-1593 VB denotes support
T7729 1594-1597 DT denotes the
T7730 1598-1602 NN denotes idea
T7731 1603-1607 IN denotes that
T7732 1608-1611 DT denotes the
T7733 1612-1616 NN denotes cIAP
T7734 1617-1625 NN denotes proteins
T7735 1626-1635 VB denotes influence
T7736 1636-1639 DT denotes the
T7737 1640-1651 NN denotes recruitment
T7738 1652-1655 CC denotes and
T7739 1656-1674 JJ denotes post-translational
T7740 1675-1687 NN denotes modification
T7741 1688-1693 NN denotes state
T7742 1694-1696 IN denotes of
T7743 1697-1712 JJ denotes CD40-associated
T7744 1713-1717 NN denotes HOIP
T7745 4172-4174 TO denotes To
T7746 4175-4179 VB denotes test
T7747 4180-4183 DT denotes the
T7748 4184-4195 NN denotes possibility
T7749 4196-4200 IN denotes that
T7750 4201-4205 NN denotes HOIP
T7751 4206-4208 VB denotes is
T7752 4209-4220 JJ denotes responsible
T7753 4221-4224 IN denotes for
T7754 4225-4228 DT denotes the
T7755 4229-4240 NN denotes recruitment
T7756 4241-4243 IN denotes of
T7757 4244-4249 JJ denotes other
T7758 4250-4258 JJ denotes critical
T7759 4259-4268 NN denotes signaling
T7760 4269-4277 NN denotes proteins
T7761 4278-4280 TO denotes to
T7762 4281-4285 NN denotes CD40
T7763 4285-4286 -COMMA- denotes ,
T7764 4287-4289 PRP denotes we
T7765 4290-4308 VB denotes immunoprecipitated
T7766 4309-4313 NN denotes CD40
T7767 4314-4323 NN denotes signaling
T7768 4324-4333 NN denotes complexes
T7769 4334-4338 IN denotes from
T7770 4339-4353 JJ denotes HOIP-deficient
T7771 4354-4357 CC denotes and
T7772 4358-4376 JJ denotes HOIP-reconstituted
T7773 4377-4382 NN denotes cells
T7774 4383-4384 -LRB- denotes (
T7775 4384-4388 NN denotes Fig.
T7776 4389-4391 NN denotes 5B
T7777 4391-4392 -RRB- denotes )
T7778 4394-4396 IN denotes As
T7779 4397-4406 VB denotes described
T7780 4407-4417 RB denotes previously
T7781 4417-4418 -COMMA- denotes ,
T7782 4419-4423 NN denotes CD40
T7783 4424-4433 NN denotes signaling
T7784 4434-4443 NN denotes complexes
T7785 4444-4462 VB denotes immunoprecipitated
T7786 4463-4467 IN denotes from
T7787 4468-4474 NN denotes A20.2J
T7788 4475-4480 NN denotes cells
T7789 4481-4490 VB denotes contained
T7790 4491-4495 NN denotes HOIP
T7791 4496-4498 RB denotes as
T7792 4499-4503 RB denotes well
T7793 4504-4506 IN denotes as
T7794 4507-4512 NN denotes TRAF2
T7795 4512-4513 -COMMA- denotes ,
T7796 4514-4519 NN denotes TRAF3
T7797 4519-4520 -COMMA- denotes ,
T7798 4521-4527 NN denotes IKKα/β
T7799 4527-4528 -COMMA- denotes ,
T7800 4529-4532 CC denotes and
T7801 4533-4537 NNP denotes IKKγ
T7802 4538-4539 -LRB- denotes [
T7803 4539-4540 CD denotes 6
T7804 4540-4541 -RRB- denotes ]
T7805 4543-4546 DT denotes The
T7806 4547-4554 NN denotes amounts
T7807 4555-4557 IN denotes of
T7808 4558-4563 NN denotes TRAF2
T7809 4563-4564 -COMMA- denotes ,
T7810 4565-4570 NN denotes TRAF3
T7811 4570-4571 -COMMA- denotes ,
T7812 4572-4575 CC denotes and
T7813 4576-4581 NN denotes cIAP1
T7814 4582-4584 IN denotes in
T7815 4585-4589 NN denotes CD40
T7816 4590-4608 NN denotes immunoprecipitates
T7817 4609-4613 IN denotes from
T7818 4614-4628 JJ denotes HOIP-deficient
T7819 4629-4634 NN denotes cells
T7820 4635-4639 VB denotes were
T7821 4640-4647 JJ denotes similar
T7822 4648-4650 TO denotes to
T7823 4651-4656 DT denotes those
T7824 4657-4661 IN denotes from
T7825 4662-4670 JJ denotes parental
T7826 4671-4677 NN denotes A20.2J
T7827 4678-4683 NN denotes cells
T7828 4683-4684 -COMMA- denotes ,
T7829 4685-4695 VB denotes indicating
T7830 4696-4700 IN denotes that
T7831 4701-4705 NN denotes HOIP
T7832 4706-4708 VB denotes is
T7833 4709-4712 RB denotes not
T7834 4713-4721 VB denotes required
T7835 4722-4725 IN denotes for
T7836 4726-4729 DT denotes the
T7837 4730-4741 NN denotes association
T7838 4742-4744 IN denotes of
T7839 4745-4750 DT denotes these
T7840 4751-4759 NN denotes proteins
T7841 4760-4764 IN denotes with
T7842 4765-4769 NN denotes CD40
T7843 4771-4773 IN denotes In
T7844 4774-4782 NN denotes contrast
T7845 4782-4783 -COMMA- denotes ,
T7846 4784-4790 NN denotes IKKα/β
T7847 4791-4794 CC denotes and
T7848 4795-4799 NN denotes IKKγ
T7849 4800-4804 VB denotes were
T7850 4805-4808 RB denotes not
T7851 4809-4819 JJ denotes detectable
T7852 4820-4822 IN denotes in
T7853 4823-4827 NN denotes CD40
T7854 4828-4846 NN denotes immunoprecipitates
T7855 4847-4856 VB denotes recovered
T7856 4857-4861 IN denotes from
T7857 4862-4876 JJ denotes HOIP-deficient
T7858 4877-4882 NN denotes cells
T7859 4883-4884 -LRB- denotes (
T7860 4884-4888 NN denotes Fig.
T7861 4889-4891 NN denotes 5B
T7862 4891-4892 -COMMA- denotes ,
T7863 4892-4893 NN denotes C
T7864 4893-4894 -RRB- denotes )
T7865 4896-4899 DT denotes The
T7866 4900-4907 NN denotes amounts
T7867 4908-4910 IN denotes of
T7868 4911-4917 NN denotes IKKα/β
T7869 4918-4921 CC denotes and
T7870 4922-4926 NN denotes IKKγ
T7871 4927-4929 IN denotes in
T7872 4930-4934 NN denotes CD40
T7873 4935-4953 NN denotes immunoprecipitates
T7874 4954-4958 IN denotes from
T7875 4959-4977 JJ denotes HOIP-reconstituted
T7876 4978-4983 NN denotes cells
T7877 4984-4988 VB denotes were
T7878 4989-4996 JJ denotes similar
T7879 4997-4999 TO denotes to
T7880 5000-5005 DT denotes those
T7881 5006-5014 VB denotes detected
T7882 5015-5017 IN denotes in
T7883 5018-5025 NN denotes samples
T7884 5026-5034 VB denotes prepared
T7885 5035-5039 IN denotes from
T7886 5040-5048 JJ denotes parental
T7887 5049-5054 NN denotes cells
T7888 5054-5055 -COMMA- denotes ,
T7889 5056-5069 VB denotes demonstrating
T7890 5070-5074 IN denotes that
T7891 5075-5078 DT denotes the
T7892 5079-5086 NN denotes defects
T7893 5087-5089 IN denotes in
T7894 5090-5093 NN denotes IKK
T7895 5094-5105 NN denotes recruitment
T7896 5106-5108 PRP denotes we
T7897 5109-5117 VB denotes observed
T7898 5118-5122 VB denotes were
T7899 5123-5126 JJ denotes due
T7900 5127-5139 RB denotes specifically
T7901 5140-5142 TO denotes to
T7902 5143-5146 DT denotes the
T7903 5147-5154 NN denotes absence
T7904 5155-5157 IN denotes of
T7905 5158-5162 NN denotes HOIP
T7906 5163-5173 NN denotes expression
T7907 5175-5180 DT denotes These
T7908 5181-5185 NN denotes data
T7909 5186-5194 VB denotes indicate
T7910 5195-5199 IN denotes that
T7911 5200-5204 NN denotes HOIP
T7912 5205-5207 VB denotes is
T7913 5208-5216 VB denotes required
T7914 5217-5220 IN denotes for
T7915 5221-5232 NN denotes recruitment
T7916 5233-5235 IN denotes of
T7917 5236-5239 DT denotes the
T7918 5240-5256 JJ denotes NF-κB-activating
T7919 5257-5264 NN denotes complex
T7920 5265-5267 TO denotes to
T7921 5268-5271 DT denotes the
T7922 5272-5276 NN denotes CD40
T7923 5277-5286 NN denotes signaling
T7924 5287-5294 NN denotes complex
T7925 5296-5298 IN denotes As
T7926 5299-5304 VB denotes shown
T7927 5305-5309 RB denotes here
T7928 5310-5313 CC denotes and
T7929 5314-5316 IN denotes in
T7930 5317-5320 PRP-DOLLAR- denotes our
T7931 5321-5329 JJ denotes previous
T7932 5330-5335 NN denotes study
T7933 5336-5337 -LRB- denotes [
T7934 5337-5338 CD denotes 6
T7935 5338-5339 -RRB- denotes ]
T7936 5339-5340 -COMMA- denotes ,
T7937 5341-5345 NN denotes IKKγ
T7938 5346-5353 JJ denotes present
T7939 5354-5356 IN denotes in
T7940 5357-5361 NN denotes CD40
T7941 5362-5380 NN denotes immunoprecipitates
T7942 5381-5388 VB denotes appears
T7943 5389-5391 TO denotes to
T7944 5392-5396 VB denotes have
T7945 5397-5398 DT denotes a
T7946 5399-5405 JJ denotes higher
T7947 5406-5415 JJ denotes molecular
T7948 5416-5422 NN denotes weight
T7949 5423-5427 IN denotes than
T7950 5428-5432 DT denotes that
T7951 5433-5438 VB denotes found
T7952 5439-5441 IN denotes in
T7953 5442-5446 NN denotes cell
T7954 5447-5454 NN denotes lysates
T7955 5456-5458 TO denotes To
T7956 5459-5466 VB denotes confirm
T7957 5467-5471 IN denotes that
T7958 5472-5476 DT denotes this
T7959 5477-5483 JJ denotes higher
T7960 5484-5493 JJ denotes molecular
T7961 5494-5500 NN denotes weight
T7962 5501-5508 NN denotes species
T7963 5509-5512 VB denotes was
T7964 5513-5519 RB denotes indeed
T7965 5520-5524 NN denotes IKKγ
T7966 5524-5525 -COMMA- denotes ,
T7967 5526-5528 PRP denotes we
T7968 5529-5538 VB denotes generated
T7969 5539-5545 NN denotes A20.2J
T7970 5546-5550 NN denotes cell
T7971 5551-5556 NN denotes lines
T7972 5557-5567 VB denotes containing
T7973 5568-5569 DT denotes a
T7974 5570-5576 RB denotes stably
T7975 5577-5587 VB denotes integrated
T7976 5588-5598 JJ denotes retroviral
T7977 5599-5605 NN denotes vector
T7978 5606-5610 WDT denotes that
T7979 5611-5618 VB denotes encoded
T7980 5619-5621 DT denotes an
T7981 5622-5636 JJ denotes epitope-tagged
T7982 5637-5644 NN denotes version
T7983 5645-5647 IN denotes of
T7984 5648-5653 NN denotes mouse
T7985 5654-5658 NN denotes IKKγ
T7986 5660-5664 NN denotes Cell
T7987 5665-5672 NN denotes lysates
T7988 5673-5676 CC denotes and
T7989 5677-5681 NN denotes CD40
T7990 5682-5700 NN denotes immunoprecipitates
T7991 5701-5709 VB denotes prepared
T7992 5710-5714 IN denotes from
T7993 5715-5720 DT denotes these
T7994 5721-5726 NN denotes cells
T7995 5727-5731 VB denotes were
T7996 5732-5740 VB denotes analyzed
T7997 5741-5743 IN denotes by
T7998 5744-5751 JJ denotes Western
T7999 5752-5760 NN denotes blotting
T8000 5761-5764 IN denotes for
T8001 5765-5768 DT denotes the
T8002 5769-5776 NN denotes epitope
T8003 5777-5780 NN denotes tag
T8004 5781-5782 -LRB- denotes (
T8005 5782-5786 NN denotes Fig.
T8006 5787-5789 NN denotes 5C
T8007 5789-5790 -RRB- denotes )
T8008 5792-5796 DT denotes This
T8009 5797-5805 NN denotes analysis
T8010 5806-5814 VB denotes produced
T8011 5815-5816 DT denotes a
T8012 5817-5824 NN denotes pattern
T8013 5825-5827 IN denotes of
T8014 5828-5833 NN denotes bands
T8015 5834-5838 WDT denotes that
T8016 5839-5842 VB denotes was
T8017 5843-5854 RB denotes essentially
T8018 5855-5858 DT denotes the
T8019 5859-5863 JJ denotes same
T8020 5864-5866 IN denotes as
T8021 5867-5871 DT denotes that
T8022 5872-5880 VB denotes obtained
T8023 5881-5886 VB denotes using
T8024 5887-5889 DT denotes an
T8025 5890-5898 NN denotes antibody
T8026 5899-5907 JJ denotes specific
T8027 5908-5911 IN denotes for
T8028 5912-5918 JJ denotes native
T8029 5919-5923 NN denotes IKKγ
T8030 5924-5925 -LRB- denotes (
T8031 5925-5932 NN denotes compare
T8032 5933-5939 NN denotes panels
T8033 5940-5941 NN denotes B
T8034 5942-5945 CC denotes and
T8035 5946-5947 NN denotes C
T8036 5948-5950 IN denotes in
T8037 5951-5955 NNP denotes Fig.
T8038 5956-5957 CD denotes 5
T8039 5957-5958 -RRB- denotes )
T8040 5960-5968 RB denotes Moreover
T8041 5968-5969 -COMMA- denotes ,
T8042 5970-5978 NN denotes analysis
T8043 5979-5981 IN denotes of
T8044 5982-5987 NN denotes cells
T8045 5988-5998 VB denotes expressing
T8046 5999-6006 NN denotes epitope
T8047 6007-6018 NN denotes tagged-IKKγ
T8048 6019-6028 VB denotes confirmed
T8049 6029-6033 IN denotes that
T8050 6034-6045 NN denotes recruitment
T8051 6046-6048 IN denotes of
T8052 6049-6053 NN denotes IKKγ
T8053 6054-6056 TO denotes to
T8054 6057-6061 NN denotes CD40
T8055 6062-6070 VB denotes requires
T8056 6071-6075 NN denotes HOIP
T8057 6077-6079 TO denotes To
T8058 6080-6089 VB denotes determine
T8059 6090-6094 WP denotes what
T8060 6095-6098 VB denotes was
T8061 6099-6110 JJ denotes responsible
T8062 6111-6114 IN denotes for
T8063 6115-6118 DT denotes the
T8064 6119-6128 VB denotes increased
T8065 6129-6138 JJ denotes molecular
T8066 6139-6145 NN denotes weight
T8067 6146-6148 IN denotes of
T8068 6149-6153 NN denotes IKKγ
T8069 6154-6156 IN denotes in
T8070 6157-6161 NN denotes CD40
T8071 6162-6180 NN denotes immunoprecipitates
T8072 6180-6181 -COMMA- denotes ,
T8073 6182-6185 DT denotes the
T8074 6186-6193 NN denotes protein
T8075 6194-6201 NN denotes samples
T8076 6202-6206 VB denotes were
T8077 6207-6216 VB denotes incubated
T8078 6217-6221 IN denotes with
T8079 6222-6228 NN denotes lambda
T8080 6229-6240 NN denotes phosphatase
T8081 6240-6241 -COMMA- denotes ,
T8082 6242-6247 WDT denotes which
T8083 6248-6255 VB denotes removes
T8084 6256-6266 NN denotes phosphates
T8085 6267-6275 VB denotes attached
T8086 6276-6278 TO denotes to
T8087 6279-6287 NN denotes tyrosine
T8088 6287-6288 -COMMA- denotes ,
T8089 6289-6298 NN denotes threonine
T8090 6298-6299 -COMMA- denotes ,
T8091 6300-6302 CC denotes or
T8092 6303-6309 NN denotes serine
T8093 6310-6318 NN denotes residues
T8094 6319-6321 IN denotes in
T8095 6322-6330 NN denotes proteins
T8096 6332-6336 DT denotes This
T8097 6337-6346 NN denotes treatment
T8098 6347-6354 VB denotes reduced
T8099 6355-6359 JJ denotes much
T8100 6360-6362 IN denotes of
T8101 6363-6378 JJ denotes CD40-associated
T8102 6379-6383 NN denotes IKKγ
T8103 6384-6386 TO denotes to
T8104 6387-6389 DT denotes an
T8105 6390-6398 JJ denotes apparent
T8106 6399-6408 JJ denotes molecular
T8107 6409-6415 NN denotes weight
T8108 6416-6423 JJ denotes similar
T8109 6424-6426 TO denotes to
T8110 6427-6431 DT denotes that
T8111 6432-6434 IN denotes of
T8112 6435-6438 DT denotes the
T8113 6439-6446 NN denotes protein
T8114 6447-6449 IN denotes in
T8115 6450-6454 NN denotes cell
T8116 6455-6462 NN denotes lysates
T8117 6463-6464 -LRB- denotes (
T8118 6464-6468 NNP denotes Fig.
T8119 6469-6471 NN denotes 5C
T8120 6471-6472 -RRB- denotes )
T8121 6474-6481 RB denotes However
T8122 6481-6482 -COMMA- denotes ,
T8123 6483-6485 IN denotes at
T8124 6486-6491 JJ denotes least
T8125 6492-6495 CD denotes one
T8126 6496-6500 NN denotes band
T8127 6501-6503 IN denotes of
T8128 6504-6517 RB denotes significantly
T8129 6518-6524 JJ denotes higher
T8130 6525-6534 JJ denotes molecular
T8131 6535-6541 NN denotes weight
T8132 6542-6550 VB denotes remained
T8133 6551-6556 IN denotes after
T8134 6557-6568 NN denotes phosphatase
T8135 6569-6578 NN denotes treatment
T8136 6578-6579 -COMMA- denotes ,
T8137 6580-6590 VB denotes suggesting
T8138 6591-6595 IN denotes that
T8139 6596-6611 JJ denotes CD40-associated
T8140 6612-6616 NN denotes IKKγ
T8141 6617-6619 VB denotes is
T8142 6620-6627 JJ denotes subject
T8143 6628-6630 TO denotes to
T8144 6631-6633 IN denotes at
T8145 6634-6639 JJ denotes least
T8146 6640-6643 CD denotes one
T8147 6644-6649 JJ denotes other
T8148 6650-6662 NN denotes modification
T8149 6663-6665 IN denotes in
T8150 6666-6674 NN denotes addition
T8151 6675-6677 TO denotes to
T8152 6678-6693 NN denotes phosphorylation
T8153 6695-6702 RB denotes Overall
T8154 6702-6703 -COMMA- denotes ,
T8155 6704-6709 DT denotes these
T8156 6710-6714 NN denotes data
T8157 6715-6726 VB denotes demonstrate
T8158 6727-6731 IN denotes that
T8159 6732-6736 NN denotes HOIP
T8160 6737-6739 VB denotes is
T8161 6740-6748 VB denotes required
T8162 6749-6752 IN denotes for
T8163 6753-6756 DT denotes the
T8164 6757-6768 NN denotes association
T8165 6769-6771 IN denotes of
T8166 6772-6776 NN denotes IKKγ
T8167 6777-6781 IN denotes with
T8168 6782-6786 NN denotes CD40
T8169 6786-6787 -COMMA- denotes ,
T8170 6788-6791 CC denotes and
T8171 6792-6799 VB denotes suggest
T8172 6800-6804 IN denotes that
T8173 6805-6809 DT denotes this
T8174 6810-6815 NN denotes event
T8175 6816-6818 VB denotes is
T8176 6819-6826 VB denotes coupled
T8177 6827-6829 TO denotes to
T8178 6830-6848 JJ denotes post-translational
T8179 6849-6862 NN denotes modifications
T8180 6863-6865 IN denotes of
T8181 6866-6870 NN denotes IKKγ
T17281 1763-1766 NN denotes IKK
T17282 1767-1778 NN denotes recruitment
T17283 1779-1781 TO denotes to
T17284 1782-1785 DT denotes the
T17285 1786-1790 NN denotes CD40
T17286 1791-1800 NN denotes signaling
T17287 1801-1808 NN denotes complex
T17288 1809-1811 VB denotes is
T17289 1812-1821 JJ denotes defective
T17290 1822-1824 IN denotes in
T17291 1825-1839 JJ denotes HOIP-deficient
T17292 1840-1845 NN denotes cells
T17293 1847-1848 -LRB- denotes (
T17294 1848-1849 NN denotes A
T17295 1849-1850 -RRB- denotes )
T17296 1851-1855 NN denotes SMAC
T17297 1856-1863 NN denotes peptide
T17298 1864-1873 NN denotes treatment
T17299 1874-1881 VB denotes reduces
T17300 1882-1893 NN denotes recruitment
T17301 1894-1896 IN denotes of
T17302 1897-1902 NN denotes cIAP1
T17303 1903-1905 TO denotes to
T17304 1906-1910 NN denotes CD40
T17305 1911-1914 CC denotes and
T17306 1915-1918 MD denotes may
T17307 1919-1925 VB denotes modify
T17308 1926-1930 NN denotes HOIP
T17309 1931-1942 NN denotes recruitment
T17310 1944-1950 NN denotes A20.2J
T17311 1951-1956 NN denotes cells
T17312 1957-1961 VB denotes were
T17313 1962-1971 VB denotes incubated
T17314 1972-1975 IN denotes for
T17315 1976-1979 CD denotes six
T17316 1980-1985 NN denotes hours
T17317 1986-1990 IN denotes with
T17318 1991-2009 JJ denotes membrane-permeable
T17319 2010-2017 NN denotes SMAC-N7
T17320 2018-2025 NN denotes peptide
T17321 2026-2028 CC denotes or
T17322 2029-2032 CD denotes 1.5
T17323 2032-2033 NN denotes %
T17324 2034-2038 NN denotes DMSO
T17325 2039-2040 -LRB- denotes (
T17326 2040-2047 NN denotes solvent
T17327 2048-2052 VB denotes used
T17328 2053-2056 IN denotes for
T17329 2057-2060 DT denotes the
T17330 2061-2068 NN denotes peptide
T17331 2068-2069 -RRB- denotes )
T17332 2071-2080 VB denotes Following
T17333 2081-2084 DT denotes the
T17334 2085-2095 NN denotes incubation
T17335 2095-2096 -COMMA- denotes ,
T17336 2097-2101 NN denotes cell
T17337 2102-2109 NN denotes lysates
T17338 2110-2114 VB denotes were
T17339 2115-2123 VB denotes prepared
T17340 2123-2124 -COMMA- denotes ,
T17341 2125-2137 VB denotes fractionated
T17342 2138-2140 IN denotes by
T17343 2141-2149 NN denotes SDS-PAGE
T17344 2149-2150 -COMMA- denotes ,
T17345 2151-2154 CC denotes and
T17346 2155-2164 VB denotes evaluated
T17347 2165-2167 IN denotes by
T17348 2168-2175 JJ denotes Western
T17349 2176-2180 NN denotes blot
T17350 2181-2182 -LRB- denotes (
T17351 2182-2187 NN denotes lanes
T17352 2188-2189 CD denotes 1
T17353 2190-2193 CC denotes and
T17354 2194-2195 CD denotes 2
T17355 2195-2196 -RRB- denotes )
T17356 2198-2203 NN denotes Cells
T17357 2204-2213 VB denotes incubated
T17358 2214-2218 IN denotes with
T17359 2219-2223 NN denotes DMSO
T17360 2224-2226 CC denotes or
T17361 2227-2234 NN denotes SMAC-N7
T17362 2235-2239 VB denotes were
T17363 2240-2244 RB denotes also
T17364 2245-2255 VB denotes stimulated
T17365 2256-2260 IN denotes with
T17366 2261-2269 JJ denotes magnetic
T17367 2270-2275 NN denotes beads
T17368 2276-2282 VB denotes coated
T17369 2283-2287 IN denotes with
T17370 2288-2297 NN denotes anti-CD40
T17371 2298-2300 CC denotes or
T17372 2301-2303 DT denotes an
T17373 2304-2311 NN denotes isotype
T17374 2312-2319 NN denotes control
T17375 2320-2328 NN denotes antibody
T17376 2330-2348 VB denotes Immunoprecipitated
T17377 2349-2350 -LRB- denotes (
T17378 2350-2352 NN denotes IP
T17379 2352-2353 -RRB- denotes )
T17380 2354-2362 NN denotes material
T17381 2363-2368 VB denotes bound
T17382 2369-2371 TO denotes to
T17383 2372-2375 DT denotes the
T17384 2376-2381 NN denotes beads
T17385 2382-2385 VB denotes was
T17386 2386-2392 VB denotes loaded
T17387 2393-2395 IN denotes in
T17388 2396-2401 NN denotes lanes
T17389 2402-2405 CD denotes 3-5
T17390 2407-2414 NN denotes Samples
T17391 2415-2417 IN denotes of
T17392 2418-2421 DT denotes the
T17393 2422-2426 NN denotes cell
T17394 2427-2434 NN denotes lysates
T17395 2435-2440 IN denotes after
T17396 2441-2460 NN denotes immunoprecipitation
T17397 2461-2467 VB denotes appear
T17398 2468-2470 IN denotes in
T17399 2471-2476 NN denotes lanes
T17400 2477-2480 CD denotes 6–8
T17401 2482-2489 JJ denotes Western
T17402 2490-2495 NN denotes blots
T17403 2496-2500 VB denotes were
T17404 2501-2507 VB denotes probed
T17405 2508-2512 IN denotes with
T17406 2513-2523 NN denotes antibodies
T17407 2524-2532 JJ denotes specific
T17408 2533-2536 IN denotes for
T17409 2537-2542 NN denotes cIAP1
T17410 2542-2543 -COMMA- denotes ,
T17411 2544-2549 NN denotes TRAF2
T17412 2549-2550 -COMMA- denotes ,
T17413 2551-2556 NN denotes TRAF3
T17414 2556-2557 -COMMA- denotes ,
T17415 2558-2561 CC denotes and
T17416 2562-2566 NN denotes HOIP
T17417 2567-2568 -LRB- denotes (
T17418 2568-2579 JJ denotes approximate
T17419 2580-2589 JJ denotes molecular
T17420 2590-2597 NN denotes weights
T17421 2598-2607 VB denotes indicated
T17422 2608-2610 IN denotes on
T17423 2611-2615 JJ denotes left
T17424 2615-2616 -RRB- denotes )
T17425 2618-2625 JJ denotes Similar
T17426 2626-2633 NN denotes results
T17427 2634-2638 VB denotes were
T17428 2639-2647 VB denotes obtained
T17429 2648-2650 IN denotes in
T17430 2651-2654 CD denotes two
T17431 2655-2665 JJ denotes additional
T17432 2666-2678 NN denotes experiments.
T17433 2679-2680 -LRB- denotes (
T17434 2680-2681 NN denotes B
T17435 2681-2682 -RRB- denotes )
T17436 2683-2687 NN denotes CD40
T17437 2688-2691 VB denotes was
T17438 2692-2700 VB denotes isolated
T17439 2701-2703 IN denotes by
T17440 2704-2723 NN denotes immunoprecipitation
T17441 2724-2725 -LRB- denotes (
T17442 2725-2727 IN denotes as
T17443 2728-2730 IN denotes in
T17444 2731-2732 -LRB- denotes (
T17445 2732-2733 NN denotes A
T17446 2733-2734 -RRB- denotes )
T17447 2734-2735 -RRB- denotes )
T17448 2736-2740 IN denotes from
T17449 2741-2747 NN denotes A20.2J
T17450 2748-2753 NN denotes cells
T17451 2754-2757 CC denotes and
T17452 2758-2772 JJ denotes HOIP-deficient
T17453 2773-2778 NN denotes cells
T17454 2779-2789 VB denotes transduced
T17455 2790-2794 IN denotes with
T17456 2795-2797 DT denotes an
T17457 2798-2803 JJ denotes empty
T17458 2804-2814 JJ denotes retroviral
T17459 2815-2821 NN denotes vector
T17460 2822-2823 -LRB- denotes (
T17461 2823-2827 NN denotes pMIP
T17462 2827-2828 -RRB- denotes )
T17463 2829-2831 CC denotes or
T17464 2832-2833 DT denotes a
T17465 2834-2844 JJ denotes retroviral
T17466 2845-2851 NN denotes vector
T17467 2852-2860 VB denotes encoding
T17468 2861-2865 NN denotes HOIP
T17469 2867-2875 NN denotes Material
T17470 2876-2894 VB denotes immunoprecipitated
T17471 2895-2899 IN denotes with
T17472 2900-2902 DT denotes an
T17473 2903-2910 NN denotes isotype
T17474 2911-2918 NN denotes control
T17475 2919-2927 NN denotes antibody
T17476 2928-2929 -LRB- denotes (
T17477 2929-2936 NN denotes isotype
T17478 2936-2937 -RRB- denotes )
T17479 2938-2940 CC denotes or
T17480 2941-2950 JJ denotes anti-CD40
T17481 2951-2959 NN denotes antibody
T17482 2960-2963 VB denotes was
T17483 2964-2972 VB denotes examined
T17484 2973-2975 IN denotes by
T17485 2976-2983 JJ denotes Western
T17486 2984-2992 NN denotes blotting
T17487 2993-2996 IN denotes for
T17488 2997-3001 NN denotes CD40
T17489 3001-3002 -COMMA- denotes ,
T17490 3003-3008 NN denotes TRAF2
T17491 3008-3009 -COMMA- denotes ,
T17492 3010-3015 NN denotes TRAF3
T17493 3015-3016 -COMMA- denotes ,
T17494 3017-3022 NN denotes cIAP1
T17495 3022-3023 -COMMA- denotes ,
T17496 3024-3028 NN denotes HOIP
T17497 3028-3029 -COMMA- denotes ,
T17498 3030-3036 NN denotes IKKα/β
T17499 3036-3037 -COMMA- denotes ,
T17500 3038-3041 CC denotes and
T17501 3042-3046 NN denotes IKKγ
T17502 3047-3048 -LRB- denotes (
T17503 3048-3053 JJ denotes right
T17504 3054-3060 NN denotes panels
T17505 3060-3061 -RRB- denotes )
T17506 3063-3067 NN denotes HOIP
T17507 3068-3078 NN denotes expression
T17508 3079-3082 VB denotes was
T17509 3083-3091 VB denotes required
T17510 3092-3095 IN denotes for
T17511 3096-3111 NN denotes coprecipitation
T17512 3112-3114 IN denotes of
T17513 3115-3118 NN denotes IKK
T17514 3119-3127 NN denotes proteins
T17515 3128-3132 IN denotes with
T17516 3133-3137 NN denotes CD40
T17517 3139-3143 NN denotes Cell
T17518 3144-3151 NN denotes lysates
T17519 3152-3156 IN denotes from
T17520 3157-3169 JJ denotes unstimulated
T17521 3170-3175 NN denotes cells
T17522 3176-3179 VB denotes are
T17523 3180-3185 VB denotes shown
T17524 3186-3188 IN denotes in
T17525 3189-3192 DT denotes the
T17526 3193-3197 JJ denotes left
T17527 3198-3204 NN denotes panels
T17528 3206-3213 JJ denotes Similar
T17529 3214-3221 NN denotes results
T17530 3222-3226 VB denotes were
T17531 3227-3235 VB denotes obtained
T17532 3236-3238 IN denotes in
T17533 3239-3240 DT denotes a
T17534 3241-3247 JJ denotes second
T17535 3248-3258 NN denotes experiment
T17536 3259-3262 CC denotes and
T17537 3263-3265 IN denotes in
T17538 3266-3269 CD denotes two
T17539 3270-3281 NN denotes experiments
T17540 3282-3286 IN denotes with
T17541 3287-3288 DT denotes a
T17542 3289-3295 JJ denotes second
T17543 3296-3310 JJ denotes HOIP-deficient
T17544 3311-3317 NN denotes clone.
T17545 3318-3319 -LRB- denotes (
T17546 3319-3320 NN denotes C
T17547 3320-3321 -RRB- denotes )
T17548 3322-3324 TO denotes To
T17549 3325-3332 RB denotes further
T17550 3333-3341 VB denotes evaluate
T17551 3342-3356 JJ denotes HOIP-dependent
T17552 3357-3368 NN denotes recruitment
T17553 3369-3371 IN denotes of
T17554 3372-3376 NN denotes IKKγ
T17555 3377-3379 TO denotes to
T17556 3380-3384 NN denotes CD40
T17557 3384-3385 -COMMA- denotes ,
T17558 3386-3392 NN denotes A20.2J
T17559 3393-3398 NN denotes cells
T17560 3399-3401 CC denotes or
T17561 3402-3416 JJ denotes HOIP-deficient
T17562 3417-3418 -LRB- denotes (
T17563 3418-3425 JJ denotes HOIP-/-
T17564 3425-3426 -RRB- denotes )
T17565 3427-3433 NN denotes A20.2J
T17566 3434-3439 NN denotes cells
T17567 3440-3444 VB denotes were
T17568 3445-3455 VB denotes transduced
T17569 3456-3460 IN denotes with
T17570 3461-3463 DT denotes an
T17571 3464-3469 JJ denotes empty
T17572 3470-3480 JJ denotes retroviral
T17573 3481-3487 NN denotes vector
T17574 3488-3490 CC denotes or
T17575 3491-3492 DT denotes a
T17576 3493-3503 JJ denotes retroviral
T17577 3504-3513 NN denotes construct
T17578 3514-3522 VB denotes encoding
T17579 3523-3525 NN denotes BP
T17580 3526-3540 JJ denotes epitope-tagged
T17581 3541-3545 NN denotes IKKγ
T17582 3546-3547 -LRB- denotes (
T17583 3547-3552 VB denotes noted
T17584 3553-3555 IN denotes in
T17585 3556-3559 DT denotes the
T17586 3560-3566 NN denotes figure
T17587 3567-3569 IN denotes as
T17588 3570-3574 NN denotes pMIP
T17589 3575-3578 CC denotes and
T17590 3579-3583 NN denotes IKKγ
T17591 3583-3584 -COMMA- denotes ,
T17592 3585-3597 RB denotes respectively
T17593 3597-3598 -RRB- denotes )
T17594 3600-3607 NN denotes Lysates
T17595 3608-3609 -LRB- denotes (
T17596 3609-3614 NN denotes lanes
T17597 3615-3618 CD denotes 1–3
T17598 3618-3619 -RRB- denotes )
T17599 3620-3623 CC denotes and
T17600 3624-3643 NN denotes immunoprecipitation
T17601 3644-3645 -LRB- denotes (
T17602 3645-3647 NN denotes IP
T17603 3647-3648 -RRB- denotes )
T17604 3649-3656 NN denotes samples
T17605 3657-3658 -LRB- denotes (
T17606 3658-3663 NN denotes lanes
T17607 3664-3668 CD denotes 4–11
T17608 3668-3669 -RRB- denotes )
T17609 3670-3674 IN denotes from
T17610 3675-3678 DT denotes the
T17611 3679-3683 NN denotes cell
T17612 3684-3689 NN denotes lines
T17613 3690-3694 VB denotes were
T17614 3695-3707 VB denotes fractionated
T17615 3708-3710 IN denotes by
T17616 3711-3719 NN denotes SDS-PAGE
T17617 3720-3723 CC denotes and
T17618 3724-3733 VB denotes evaluated
T17619 3734-3736 IN denotes by
T17620 3737-3744 JJ denotes Western
T17621 3745-3753 NN denotes blotting
T17622 3754-3758 IN denotes with
T17623 3759-3769 NN denotes antibodies
T17624 3770-3772 TO denotes to
T17625 3773-3776 DT denotes the
T17626 3777-3779 NN denotes BP
T17627 3780-3783 NN denotes tag
T17628 3784-3785 -LRB- denotes (
T17629 3785-3789 NN denotes IKKγ
T17630 3789-3790 -COMMA- denotes ,
T17631 3791-3796 JJ denotes upper
T17632 3797-3802 NN denotes panel
T17633 3802-3803 -RRB- denotes )
T17634 3804-3807 CC denotes and
T17635 3808-3813 NN denotes TRAF2
T17636 3815-3818 DT denotes The
T17637 3819-3828 JJ denotes anti-CD40
T17638 3829-3831 NN denotes IP
T17639 3832-3838 NN denotes sample
T17640 3839-3841 IN denotes in
T17641 3842-3846 NN denotes lane
T17642 3847-3849 CD denotes 11
T17643 3850-3853 VB denotes was
T17644 3854-3861 VB denotes treated
T17645 3862-3866 IN denotes with
T17646 3867-3868 NN denotes λ
T17647 3869-3880 NN denotes phosphatase
T17648 3880-3881 -COLON- denotes ;
T17649 3882-3885 DT denotes the
T17650 3886-3892 NN denotes sample
T17651 3893-3895 IN denotes in
T17652 3896-3900 NN denotes lane
T17653 3901-3903 CD denotes 10
T17654 3904-3907 VB denotes was
T17655 3908-3920 JJ denotes mock-treated
T17656 3922-3929 NN denotes Protein
T17657 3930-3937 NN denotes samples
T17658 3938-3939 -LRB- denotes (
T17659 3939-3944 CC denotes minus
T17660 3945-3950 DT denotes those
T17661 3951-3958 VB denotes treated
T17662 3959-3963 IN denotes with
T17663 3964-3975 NN denotes phosphatase
T17664 3975-3976 -RRB- denotes )
T17665 3977-3981 VB denotes were
T17666 3982-3986 RB denotes also
T17667 3987-3999 VB denotes fractionated
T17668 4000-4002 IN denotes on
T17669 4003-4004 DT denotes a
T17670 4005-4013 JJ denotes separate
T17671 4014-4017 NN denotes gel
T17672 4018-4019 -LRB- denotes (
T17673 4019-4024 JJ denotes lower
T17674 4025-4035 NN denotes acrylamide
T17675 4036-4049 NN denotes concentration
T17676 4049-4050 -RRB- denotes )
T17677 4051-4054 IN denotes for
T17678 4055-4058 DT denotes the
T17679 4059-4069 NN denotes evaluation
T17680 4070-4072 IN denotes of
T17681 4073-4078 NN denotes TRAF3
T17682 4079-4082 CC denotes and
T17683 4083-4087 NN denotes HOIP
T17684 4088-4089 -LRB- denotes (
T17685 4089-4095 NN denotes bottom
T17686 4096-4099 CD denotes two
T17687 4100-4106 NN denotes panels
T17688 4106-4107 -RRB- denotes )
T17689 4109-4116 JJ denotes Similar
T17690 4117-4124 NN denotes results
T17691 4125-4129 VB denotes were
T17692 4130-4138 VB denotes obtained
T17693 4139-4141 IN denotes in
T17694 4142-4145 CD denotes two
T17695 4146-4156 JJ denotes additional
T17696 4157-4168 NN denotes experiments
R5843 T7485 T7484 arg2Of CD40,with
R5844 T7488 T7486 arg1Of defects,The
R5845 T7488 T7487 arg1Of defects,marked
R5846 T7488 T7489 arg1Of defects,in
R5847 T7488 T7495 arg2Of defects,displayed
R5848 T7488 T7499 arg1Of defects,suggested
R5849 T7492 T7493 arg1Of activation,and
R5850 T7493 T7489 arg2Of and,in
R5851 T7493 T7490 arg1Of and,CD40-mediated
R5852 T7493 T7491 arg1Of and,cell
R5853 T7494 T7493 arg2Of signaling,and
R5854 T7498 T7495 arg1Of cells,displayed
R5855 T7498 T7496 arg2Of cells,by
R5856 T7498 T7497 arg1Of cells,HOIP-deficient
R5857 T7501 T7502 arg1Of HOIP,mediates
R5858 T7502 T7499 arg2Of mediates,suggested
R5859 T7502 T7500 arg1Of mediates,that
R5860 T7503 T7502 arg2Of recruitment,mediates
R5861 T7503 T7504 arg1Of recruitment,of
R5862 T7503 T7512 arg1Of recruitment,to
R5863 T7506 T7504 arg2Of components,of
R5864 T7506 T7505 arg1Of components,critical
R5865 T7506 T7507 arg1Of components,of
R5866 T7511 T7507 arg2Of apparatus,of
R5867 T7511 T7508 arg1Of apparatus,the
R5868 T7511 T7509 arg1Of apparatus,CD40
R5869 T7511 T7510 arg1Of apparatus,signaling
R5870 T7514 T7512 arg2Of receptor,to
R5871 T7514 T7513 arg1Of receptor,the
R5872 T7517 T7518 arg1Of we,demonstrated
R5873 T7518 T7515 arg1Of demonstrated,Previously
R5874 T7518 T7516 arg1Of demonstrated,","
R5875 T7520 T7521 arg1Of HOIP,is
R5876 T7520 T7522 arg2Of HOIP,recruited
R5877 T7522 T7518 arg2Of recruited,demonstrated
R5878 T7522 T7519 arg1Of recruited,that
R5879 T7522 T7521 arg2Of recruited,is
R5880 T7522 T7523 arg1Of recruited,to
R5881 T7522 T7528 arg1Of recruited,in
R5882 T7522 T7532 arg1Of recruited,","
R5883 T7522 T7533 modOf recruited,suggesting
R5884 T7522 T7540 arg1Of recruited,[
R5885 T7527 T7523 arg2Of complex,to
R5886 T7527 T7524 arg1Of complex,the
R5887 T7527 T7525 arg1Of complex,CD40
R5888 T7527 T7526 arg1Of complex,signaling
R5889 T7531 T7528 arg2Of manner,in
R5890 T7531 T7529 arg1Of manner,a
R5891 T7531 T7530 arg1Of manner,TRAF2-dependent
R5892 T7536 T7533 arg2Of functions,suggesting
R5893 T7536 T7534 arg1Of functions,that
R5894 T7536 T7535 arg1Of functions,HOIP
R5895 T7536 T7537 arg1Of functions,downstream
R5896 T7537 T7538 arg1Of downstream,of
R5897 T7539 T7538 arg2Of TRAF2,of
R5898 T7541 T7540 arg2Of 6,[
R5899 T7542 T7540 arg3Of ],[
R5900 T7543 T7544 arg1Of Studies,by
R5901 T7543 T7546 arg1Of Studies,suggest
R5902 T7545 T7544 arg2Of others,by
R5903 T7550 T7548 arg1Of proteins,the
R5904 T7550 T7549 arg1Of proteins,TRAF2-associated
R5905 T7551 T7552 arg1Of cIAP1,and
R5906 T7552 T7550 arg1Of and,proteins
R5907 T7552 T7554 arg1Of and,play
R5908 T7553 T7552 arg2Of cIAP2,and
R5909 T7554 T7546 arg2Of play,suggest
R5910 T7554 T7547 arg1Of play,that
R5911 T7554 T7557 arg1Of play,in
R5912 T7554 T7566 arg1Of play,[
R5913 T7556 T7554 arg2Of role,play
R5914 T7556 T7555 arg1Of role,a
R5915 T7559 T7557 arg2Of recruitment,in
R5916 T7559 T7558 arg1Of recruitment,the
R5917 T7559 T7560 arg1Of recruitment,of
R5918 T7559 T7562 arg1Of recruitment,to
R5919 T7561 T7560 arg2Of HOIP,of
R5920 T7563 T7564 arg1Of TNFR1,and
R5921 T7564 T7562 arg2Of and,to
R5922 T7565 T7564 arg2Of CD40,and
R5923 T7567 T7566 arg2Of 14,[
R5924 T7568 T7566 arg3Of ],[
R5925 T7571 T7572 arg1Of we,determined
R5926 T7572 T7569 arg1Of determined,Therefore
R5927 T7572 T7570 arg1Of determined,","
R5928 T7575 T7574 arg1Of association,the
R5929 T7575 T7576 arg1Of association,of
R5930 T7575 T7578 arg1Of association,with
R5931 T7575 T7580 arg1Of association,in
R5932 T7575 T7583 arg1Of association,was
R5933 T7575 T7584 arg2Of association,altered
R5934 T7577 T7576 arg2Of HOIP,of
R5935 T7579 T7578 arg2Of CD40,with
R5936 T7582 T7580 arg2Of cells,in
R5937 T7582 T7581 arg1Of cells,A20.2J
R5938 T7584 T7572 arg2Of altered,determined
R5939 T7584 T7573 arg1Of altered,whether
R5940 T7584 T7583 arg2Of altered,was
R5941 T7584 T7605 arg1Of altered,[
R5942 T7586 T7584 arg1Of treatment,altered
R5943 T7586 T7585 arg2Of treatment,by
R5944 T7586 T7587 arg1Of treatment,of
R5945 T7586 T7589 arg1Of treatment,with
R5946 T7586 T7599 arg2Of treatment,derived
R5947 T7588 T7587 arg2Of cells,of
R5948 T7591 T7589 arg2Of inhibitor,with
R5949 T7591 T7590 arg1Of inhibitor,an
R5950 T7591 T7592 arg1Of inhibitor,of
R5951 T7591 T7595 arg1Of inhibitor,","
R5952 T7594 T7592 arg2Of activity,of
R5953 T7594 T7593 arg1Of activity,cIAP
R5954 T7598 T7595 arg2Of peptide,","
R5955 T7598 T7596 arg1Of peptide,a
R5956 T7598 T7597 arg1Of peptide,membrane-permeable
R5957 T7599 T7600 arg1Of derived,from
R5958 T7604 T7600 arg2Of SMAC,from
R5959 T7604 T7601 arg1Of SMAC,the
R5960 T7604 T7602 arg1Of SMAC,apoptosis
R5961 T7604 T7603 arg1Of SMAC,regulator
R5962 T7606 T7605 arg2Of 15,[
R5963 T7607 T7605 arg3Of ],[
R5964 T7608 T7609 arg1Of We,found
R5965 T7611 T7612 arg1Of pretreatment,of
R5966 T7611 T7614 arg1Of pretreatment,with
R5967 T7611 T7619 arg1Of pretreatment,reduced
R5968 T7613 T7612 arg2Of cells,of
R5969 T7617 T7614 arg2Of peptide,with
R5970 T7617 T7615 arg1Of peptide,the
R5971 T7617 T7616 arg1Of peptide,SMAC
R5972 T7619 T7609 arg2Of reduced,found
R5973 T7619 T7610 arg1Of reduced,that
R5974 T7619 T7618 arg1Of reduced,dramatically
R5975 T7621 T7619 arg2Of amount,reduced
R5976 T7621 T7620 arg1Of amount,the
R5977 T7621 T7622 arg1Of amount,of
R5978 T7621 T7624 arg2Of amount,associated
R5979 T7623 T7622 arg2Of cIAP1,of
R5980 T7624 T7625 arg1Of associated,with
R5981 T7629 T7625 arg2Of complex,with
R5982 T7629 T7626 arg1Of complex,the
R5983 T7629 T7627 arg1Of complex,CD40
R5984 T7629 T7628 arg1Of complex,signaling
R5985 T7629 T7630 arg1Of complex,in
R5986 T7631 T7630 arg2Of cells,in
R5987 T7631 T7632 arg2Of cells,stimulated
R5988 T7632 T7633 arg1Of stimulated,with
R5989 T7636 T7633 arg2Of beads,with
R5990 T7636 T7634 arg1Of beads,anti-CD40
R5991 T7636 T7635 arg1Of beads,antibody-coated
R5992 T7636 T7637 arg1Of beads,(
R5993 T7639 T7637 arg2Of 5A,(
R5994 T7639 T7638 arg1Of 5A,Fig.
R5995 T7640 T7637 arg3Of ),(
R5996 T7643 T7641 arg1Of treatment,SMAC
R5997 T7643 T7642 arg1Of treatment,peptide
R5998 T7643 T7645 arg1Of treatment,resulted
R5999 T7645 T7644 arg1Of resulted,also
R6000 T7645 T7646 arg1Of resulted,in
R6001 T7648 T7649 arg1Of slight,but
R6002 T7650 T7649 arg2Of reproducible,but
R6003 T7651 T7646 arg2Of decrease,in
R6004 T7651 T7647 arg1Of decrease,a
R6005 T7651 T7648 arg1Of decrease,slight
R6006 T7651 T7650 arg1Of decrease,reproducible
R6007 T7651 T7652 arg1Of decrease,in
R6008 T7651 T7664 arg1Of decrease,","
R6009 T7651 T7665 arg1Of decrease,along
R6010 T7654 T7652 arg2Of amount,in
R6011 T7654 T7653 arg1Of amount,the
R6012 T7654 T7655 arg1Of amount,of
R6013 T7659 T7655 arg2Of form,of
R6014 T7659 T7656 arg1Of form,the
R6015 T7659 T7657 arg1Of form,major
R6016 T7659 T7658 arg1Of form,HOIP
R6017 T7659 T7660 arg2Of form,recovered
R6018 T7663 T7660 arg1Of immunoprecipitation,recovered
R6019 T7663 T7661 arg2Of immunoprecipitation,by
R6020 T7663 T7662 arg1Of immunoprecipitation,CD40
R6021 T7665 T7666 arg1Of along,with
R6022 T7669 T7666 arg2Of increase,with
R6023 T7669 T7667 arg1Of increase,an
R6024 T7669 T7668 arg1Of increase,apparent
R6025 T7669 T7670 arg1Of increase,in
R6026 T7674 T7670 arg2Of species,in
R6027 T7674 T7671 arg1Of species,higher
R6028 T7674 T7672 arg1Of species,molecular
R6029 T7674 T7673 arg1Of species,weight
R6030 T7674 T7675 arg2Of species,recognized
R6031 T7678 T7675 arg1Of antibody,recognized
R6032 T7678 T7676 arg2Of antibody,by
R6033 T7678 T7677 arg1Of antibody,anti-HOIP
R6034 T7680 T7679 arg2Of contrast,In
R6035 T7682 T7683 arg1Of treatment,with
R6036 T7682 T7687 arg1Of treatment,did
R6037 T7682 T7689 arg1Of treatment,alter
R6038 T7686 T7683 arg2Of peptide,with
R6039 T7686 T7684 arg1Of peptide,the
R6040 T7686 T7685 arg1Of peptide,SMAC
R6041 T7689 T7679 arg1Of alter,In
R6042 T7689 T7681 arg1Of alter,","
R6043 T7689 T7687 arg2Of alter,did
R6044 T7689 T7688 arg1Of alter,not
R6045 T7691 T7692 arg1Of amount,or
R6046 T7692 T7689 arg2Of or,alter
R6047 T7692 T7690 arg1Of or,the
R6048 T7692 T7695 arg1Of or,of
R6049 T7692 T7697 arg1Of or,present
R6050 T7694 T7692 arg2Of weight,or
R6051 T7694 T7693 arg1Of weight,molecular
R6052 T7696 T7695 arg2Of HOIP,of
R6053 T7697 T7698 arg1Of present,in
R6054 T7700 T7698 arg2Of lysates,in
R6055 T7700 T7699 arg1Of lysates,cell
R6056 T7702 T7701 arg1Of data,These
R6057 T7702 T7703 arg1Of data,suggest
R6058 T7707 T7705 arg1Of treatment,SMAC
R6059 T7707 T7706 arg1Of treatment,peptide
R6060 T7707 T7709 arg1Of treatment,alters
R6061 T7709 T7703 arg2Of alters,suggest
R6062 T7709 T7704 arg1Of alters,that
R6063 T7709 T7708 arg1Of alters,specifically
R6064 T7711 T7710 arg1Of characteristics,the
R6065 T7711 T7712 arg1Of characteristics,of
R6066 T7711 T7716 arg1Of characteristics,than
R6067 T7714 T7712 arg2Of HOIP,of
R6068 T7714 T7713 arg1Of HOIP,CD40-associated
R6069 T7716 T7709 arg2Of than,alters
R6070 T7716 T7715 arg1Of than,rather
R6071 T7720 T7716 arg2Of pool,than
R6072 T7720 T7717 arg1Of pool,the
R6073 T7720 T7718 arg1Of pool,entire
R6074 T7720 T7719 arg1Of pool,cellular
R6075 T7720 T7721 arg1Of pool,of
R6076 T7723 T7721 arg2Of protein,of
R6077 T7723 T7722 arg1Of protein,this
R6078 T7727 T7726 arg1Of results,these
R6079 T7727 T7728 arg1Of results,support
R6080 T7728 T7724 arg1Of support,Together
R6081 T7728 T7725 arg1Of support,","
R6082 T7730 T7728 arg2Of idea,support
R6083 T7730 T7729 arg1Of idea,the
R6084 T7734 T7732 arg1Of proteins,the
R6085 T7734 T7733 arg1Of proteins,cIAP
R6086 T7734 T7735 arg1Of proteins,influence
R6087 T7735 T7730 arg2Of influence,idea
R6088 T7735 T7731 arg1Of influence,that
R6089 T7737 T7736 arg1Of recruitment,the
R6090 T7737 T7738 arg1Of recruitment,and
R6091 T7738 T7735 arg2Of and,influence
R6092 T7738 T7742 arg1Of and,of
R6093 T7741 T7738 arg2Of state,and
R6094 T7741 T7739 arg1Of state,post-translational
R6095 T7741 T7740 arg1Of state,modification
R6096 T7744 T7742 arg2Of HOIP,of
R6097 T7744 T7743 arg1Of HOIP,CD40-associated
R6098 T7746 T7745 arg1Of test,To
R6099 T7748 T7746 arg2Of possibility,test
R6100 T7748 T7747 arg1Of possibility,the
R6101 T7750 T7751 arg1Of HOIP,is
R6102 T7750 T7752 arg1Of HOIP,responsible
R6103 T7751 T7748 arg2Of is,possibility
R6104 T7751 T7749 arg1Of is,that
R6105 T7752 T7751 arg2Of responsible,is
R6106 T7752 T7753 arg1Of responsible,for
R6107 T7755 T7753 arg2Of recruitment,for
R6108 T7755 T7754 arg1Of recruitment,the
R6109 T7755 T7756 arg1Of recruitment,of
R6110 T7755 T7761 arg1Of recruitment,to
R6111 T7760 T7756 arg2Of proteins,of
R6112 T7760 T7757 arg1Of proteins,other
R6113 T7760 T7758 arg1Of proteins,critical
R6114 T7760 T7759 arg1Of proteins,signaling
R6115 T7762 T7761 arg2Of CD40,to
R6116 T7764 T7746 arg1Of we,test
R6117 T7764 T7765 arg1Of we,immunoprecipitated
R6118 T7765 T7745 modOf immunoprecipitated,To
R6119 T7765 T7763 arg1Of immunoprecipitated,","
R6120 T7768 T7765 arg2Of complexes,immunoprecipitated
R6121 T7768 T7766 arg1Of complexes,CD40
R6122 T7768 T7767 arg1Of complexes,signaling
R6123 T7768 T7769 arg1Of complexes,from
R6124 T7770 T7771 arg1Of HOIP-deficient,and
R6125 T7772 T7771 arg2Of HOIP-reconstituted,and
R6126 T7773 T7769 arg2Of cells,from
R6127 T7773 T7770 arg1Of cells,HOIP-deficient
R6128 T7773 T7772 arg1Of cells,HOIP-reconstituted
R6129 T7773 T7774 arg1Of cells,(
R6130 T7776 T7774 arg2Of 5B,(
R6131 T7776 T7775 arg1Of 5B,Fig.
R6132 T7777 T7774 arg3Of ),(
R6133 T7779 T7778 arg2Of described,As
R6134 T7779 T7780 arg1Of described,previously
R6135 T7784 T7782 arg1Of complexes,CD40
R6136 T7784 T7783 arg1Of complexes,signaling
R6137 T7784 T7785 arg2Of complexes,immunoprecipitated
R6138 T7784 T7789 arg1Of complexes,contained
R6139 T7785 T7786 arg1Of immunoprecipitated,from
R6140 T7788 T7786 arg2Of cells,from
R6141 T7788 T7787 arg1Of cells,A20.2J
R6142 T7789 T7778 arg1Of contained,As
R6143 T7789 T7781 arg1Of contained,","
R6144 T7790 T7793 arg1Of HOIP,as
R6145 T7793 T7789 arg2Of as,contained
R6146 T7793 T7791 arg1Of as,as
R6147 T7793 T7792 arg1Of as,well
R6148 T7794 T7795 arg1Of TRAF2,","
R6149 T7795 T7797 arg1Of ",",","
R6150 T7796 T7795 arg2Of TRAF3,","
R6151 T7797 T7800 arg1Of ",",and
R6152 T7798 T7797 arg2Of IKKα/β,","
R6153 T7800 T7793 arg2Of and,as
R6154 T7800 T7799 arg1Of and,","
R6155 T7801 T7800 arg2Of IKKγ,and
R6156 T7801 T7802 arg1Of IKKγ,[
R6157 T7803 T7802 arg2Of 6,[
R6158 T7804 T7802 arg3Of ],[
R6159 T7806 T7805 arg1Of amounts,The
R6160 T7861 T7859 arg2Of 5B,(
R6161 T7861 T7860 arg1Of 5B,Fig.
R6162 T7861 T7862 arg1Of 5B,","
R6163 T7806 T7807 arg1Of amounts,of
R6164 T7806 T7814 arg1Of amounts,in
R6165 T7863 T7862 arg2Of C,","
R6166 T7864 T7859 arg3Of ),(
R6167 T7806 T7820 arg1Of amounts,were
R6168 T7866 T7865 arg1Of amounts,The
R6169 T7866 T7867 arg1Of amounts,of
R6170 T7866 T7871 arg1Of amounts,in
R6171 T7866 T7877 arg1Of amounts,were
R6172 T7866 T7878 arg1Of amounts,similar
R6173 T7866 T7881 arg2Of amounts,detected
R6174 T7868 T7869 arg1Of IKKα/β,and
R6175 T7806 T7821 arg1Of amounts,similar
R6176 T7869 T7867 arg2Of and,of
R6177 T7808 T7809 arg1Of TRAF2,","
R6178 T7870 T7869 arg2Of IKKγ,and
R6179 T7873 T7871 arg2Of immunoprecipitates,in
R6180 T7873 T7872 arg1Of immunoprecipitates,CD40
R6181 T7873 T7874 arg1Of immunoprecipitates,from
R6182 T7809 T7812 arg1Of ",",and
R6183 T7876 T7874 arg2Of cells,from
R6184 T7876 T7875 arg1Of cells,HOIP-reconstituted
R6185 T7810 T7809 arg2Of TRAF3,","
R6186 T7878 T7879 arg1Of similar,to
R6187 T7880 T7879 arg2Of those,to
R6188 T7812 T7807 arg2Of and,of
R6189 T7881 T7877 arg2Of detected,were
R6190 T7881 T7878 modOf detected,similar
R6191 T7881 T7882 arg1Of detected,in
R6192 T7881 T7888 arg1Of detected,","
R6193 T7883 T7882 arg2Of samples,in
R6194 T7883 T7884 arg2Of samples,prepared
R6195 T7884 T7885 arg1Of prepared,from
R6196 T7812 T7811 arg1Of and,","
R6197 T7813 T7812 arg2Of cIAP1,and
R6198 T7887 T7885 arg2Of cells,from
R6199 T7887 T7886 arg1Of cells,parental
R6200 T7889 T7881 arg3Of demonstrating,detected
R6201 T7816 T7814 arg2Of immunoprecipitates,in
R6202 T7892 T7891 arg1Of defects,the
R6203 T7892 T7893 arg1Of defects,in
R6204 T7892 T7898 arg1Of defects,were
R6205 T7892 T7899 arg1Of defects,due
R6206 T7895 T7893 arg2Of recruitment,in
R6207 T7895 T7894 arg1Of recruitment,IKK
R6208 T7895 T7897 arg2Of recruitment,observed
R6209 T7896 T7897 arg1Of we,observed
R6210 T7816 T7815 arg1Of immunoprecipitates,CD40
R6211 T7898 T7889 arg2Of were,demonstrating
R6212 T7898 T7890 arg1Of were,that
R6213 T7816 T7817 arg1Of immunoprecipitates,from
R6214 T7899 T7898 arg2Of due,were
R6215 T7819 T7817 arg2Of cells,from
R6216 T7899 T7901 arg1Of due,to
R6217 T7901 T7900 arg1Of to,specifically
R6218 T7903 T7901 arg2Of absence,to
R6219 T7903 T7902 arg1Of absence,the
R6220 T7903 T7904 arg1Of absence,of
R6221 T7819 T7818 arg1Of cells,HOIP-deficient
R6222 T7820 T7828 arg1Of were,","
R6223 T7906 T7904 arg2Of expression,of
R6224 T7906 T7905 arg1Of expression,HOIP
R6225 T7908 T7907 arg1Of data,These
R6226 T7908 T7909 arg1Of data,indicate
R6227 T7820 T7829 modOf were,indicating
R6228 T7821 T7820 arg2Of similar,were
R6229 T7911 T7912 arg1Of HOIP,is
R6230 T7911 T7913 arg2Of HOIP,required
R6231 T7821 T7822 arg1Of similar,to
R6232 T7913 T7909 arg2Of required,indicate
R6233 T7913 T7910 arg1Of required,that
R6234 T7913 T7912 arg2Of required,is
R6235 T7913 T7914 arg1Of required,for
R6236 T7823 T7822 arg2Of those,to
R6237 T7915 T7914 arg2Of recruitment,for
R6238 T7915 T7916 arg1Of recruitment,of
R6239 T7915 T7920 arg1Of recruitment,to
R6240 T7823 T7824 arg1Of those,from
R6241 T7919 T7916 arg2Of complex,of
R6242 T7919 T7917 arg1Of complex,the
R6243 T7919 T7918 arg1Of complex,NF-κB-activating
R6244 T7827 T7824 arg2Of cells,from
R6245 T7924 T7920 arg2Of complex,to
R6246 T7924 T7921 arg1Of complex,the
R6247 T7924 T7922 arg1Of complex,CD40
R6248 T7924 T7923 arg1Of complex,signaling
R6249 T7926 T7925 arg2Of shown,As
R6250 T7827 T7825 arg1Of cells,parental
R6251 T7827 T7826 arg1Of cells,A20.2J
R6252 T7831 T7832 arg1Of HOIP,is
R6253 T7926 T7927 arg1Of shown,here
R6254 T7926 T7929 arg1Of shown,in
R6255 T7926 T7933 arg1Of shown,[
R6256 T7927 T7928 arg1Of here,and
R6257 T7929 T7928 arg2Of in,and
R6258 T7831 T7834 arg2Of HOIP,required
R6259 T7932 T7929 arg2Of study,in
R6260 T7932 T7930 arg1Of study,our
R6261 T7932 T7931 arg1Of study,previous
R6262 T7834 T7829 arg2Of required,indicating
R6263 T7934 T7933 arg2Of 6,[
R6264 T7935 T7933 arg3Of ],[
R6265 T7937 T7938 arg1Of IKKγ,present
R6266 T7937 T7942 arg1Of IKKγ,appears
R6267 T7937 T7944 arg1Of IKKγ,have
R6268 T7938 T7939 arg1Of present,in
R6269 T7941 T7939 arg2Of immunoprecipitates,in
R6270 T7941 T7940 arg1Of immunoprecipitates,CD40
R6271 T7834 T7830 arg1Of required,that
R6272 T7942 T7925 arg1Of appears,As
R6273 T7942 T7936 arg1Of appears,","
R6274 T7834 T7832 arg2Of required,is
R6275 T7944 T7942 arg2Of have,appears
R6276 T7944 T7943 arg1Of have,to
R6277 T7944 T7949 arg1Of have,than
R6278 T7834 T7833 arg1Of required,not
R6279 T7834 T7835 arg1Of required,for
R6280 T7837 T7835 arg2Of association,for
R6281 T7948 T7944 arg2Of weight,have
R6282 T7948 T7945 arg1Of weight,a
R6283 T7948 T7946 arg1Of weight,higher
R6284 T7948 T7947 arg1Of weight,molecular
R6285 T7950 T7949 arg2Of that,than
R6286 T7950 T7951 arg2Of that,found
R6287 T7951 T7952 arg1Of found,in
R6288 T7837 T7836 arg1Of association,the
R6289 T7954 T7952 arg2Of lysates,in
R6290 T7954 T7953 arg1Of lysates,cell
R6291 T7837 T7838 arg1Of association,of
R6292 T7956 T7955 arg1Of confirm,To
R6293 T7837 T7841 arg1Of association,with
R6294 T7840 T7838 arg2Of proteins,of
R6295 T7840 T7839 arg1Of proteins,these
R6296 T7842 T7841 arg2Of CD40,with
R6297 T7844 T7843 arg2Of contrast,In
R6298 T7846 T7847 arg1Of IKKα/β,and
R6299 T7962 T7958 arg1Of species,this
R6300 T7962 T7959 arg1Of species,higher
R6301 T7962 T7960 arg1Of species,molecular
R6302 T7962 T7961 arg1Of species,weight
R6303 T7962 T7963 arg1Of species,was
R6304 T7963 T7956 arg2Of was,confirm
R6305 T7963 T7957 arg1Of was,that
R6306 T7963 T7964 arg1Of was,indeed
R6307 T7965 T7963 arg2Of IKKγ,was
R6308 T7847 T7849 arg1Of and,were
R6309 T7967 T7956 arg1Of we,confirm
R6310 T7967 T7968 arg1Of we,generated
R6311 T7968 T7955 modOf generated,To
R6312 T7968 T7966 arg1Of generated,","
R6313 T7847 T7851 arg1Of and,detectable
R6314 T7971 T7968 arg2Of lines,generated
R6315 T7971 T7969 arg1Of lines,A20.2J
R6316 T7971 T7970 arg1Of lines,cell
R6317 T7971 T7972 arg1Of lines,containing
R6318 T7848 T7847 arg2Of IKKγ,and
R6319 T7975 T7974 arg1Of integrated,stably
R6320 T7849 T7843 arg1Of were,In
R6321 T7977 T7972 arg2Of vector,containing
R6322 T7977 T7973 arg1Of vector,a
R6323 T7977 T7975 arg1Of vector,integrated
R6324 T7977 T7976 arg1Of vector,retroviral
R6325 T7977 T7978 arg1Of vector,that
R6326 T7977 T7979 arg1Of vector,encoded
R6327 T7849 T7845 arg1Of were,","
R6328 T7849 T7850 arg1Of were,not
R6329 T7849 T7852 arg1Of were,in
R6330 T7982 T7979 arg2Of version,encoded
R6331 T7982 T7980 arg1Of version,an
R6332 T7982 T7981 arg1Of version,epitope-tagged
R6333 T7982 T7983 arg1Of version,of
R6334 T7851 T7849 arg2Of detectable,were
R6335 T7985 T7983 arg2Of IKKγ,of
R6336 T7985 T7984 arg1Of IKKγ,mouse
R6337 T7854 T7852 arg2Of immunoprecipitates,in
R6338 T7987 T7986 arg1Of lysates,Cell
R6339 T7987 T7988 arg1Of lysates,and
R6340 T7988 T7995 arg1Of and,were
R6341 T7988 T7996 arg2Of and,analyzed
R6342 T7990 T7988 arg2Of immunoprecipitates,and
R6343 T7990 T7989 arg1Of immunoprecipitates,CD40
R6344 T7990 T7991 arg2Of immunoprecipitates,prepared
R6345 T7991 T7992 arg1Of prepared,from
R6346 T7854 T7853 arg1Of immunoprecipitates,CD40
R6347 T7854 T7855 arg2Of immunoprecipitates,recovered
R6348 T7994 T7992 arg2Of cells,from
R6349 T7994 T7993 arg1Of cells,these
R6350 T7855 T7856 arg1Of recovered,from
R6351 T7996 T7995 arg2Of analyzed,were
R6352 T7996 T7997 arg1Of analyzed,by
R6353 T7858 T7856 arg2Of cells,from
R6354 T7999 T7997 arg2Of blotting,by
R6355 T7999 T7998 arg1Of blotting,Western
R6356 T7999 T8000 arg1Of blotting,for
R6357 T8003 T8000 arg2Of tag,for
R6358 T8003 T8001 arg1Of tag,the
R6359 T8003 T8002 arg1Of tag,epitope
R6360 T8003 T8004 arg1Of tag,(
R6361 T7858 T7857 arg1Of cells,HOIP-deficient
R6362 T7858 T7859 arg1Of cells,(
R6363 T8006 T8004 arg2Of 5C,(
R6364 T8006 T8005 arg1Of 5C,Fig.
R6365 T8054 T8053 arg2Of CD40,to
R6366 T8007 T8004 arg3Of ),(
R6367 T8009 T8008 arg1Of analysis,This
R6368 T8009 T8010 arg1Of analysis,produced
R6369 T8012 T8010 arg2Of pattern,produced
R6370 T8012 T8011 arg1Of pattern,a
R6371 T8012 T8013 arg1Of pattern,of
R6372 T8012 T8015 arg1Of pattern,that
R6373 T8012 T8016 arg1Of pattern,was
R6374 T8014 T8013 arg2Of bands,of
R6375 T8016 T8017 arg1Of was,essentially
R6376 T8016 T8023 modOf was,using
R6377 T8055 T8048 arg2Of requires,confirmed
R6378 T8019 T8016 arg2Of same,was
R6379 T8019 T8018 arg1Of same,the
R6380 T8019 T8020 arg1Of same,as
R6381 T8019 T8022 arg2Of same,obtained
R6382 T8021 T8020 arg2Of that,as
R6383 T8055 T8049 arg1Of requires,that
R6384 T8056 T8055 arg2Of HOIP,requires
R6385 T8025 T8023 arg2Of antibody,using
R6386 T8025 T8024 arg1Of antibody,an
R6387 T8025 T8026 arg1Of antibody,specific
R6388 T8026 T8027 arg1Of specific,for
R6389 T8058 T8057 arg1Of determine,To
R6390 T8029 T8027 arg2Of IKKγ,for
R6391 T8029 T8028 arg1Of IKKγ,native
R6392 T8029 T8030 arg1Of IKKγ,(
R6393 T8059 T8058 arg2Of what,determine
R6394 T8033 T8034 arg1Of B,and
R6395 T8034 T8030 arg2Of and,(
R6396 T8034 T8031 arg1Of and,compare
R6397 T8034 T8032 arg1Of and,panels
R6398 T8034 T8036 arg1Of and,in
R6399 T8035 T8034 arg2Of C,and
R6400 T8037 T8036 arg2Of Fig.,in
R6401 T8037 T8038 arg1Of Fig.,5
R6402 T8059 T8060 arg1Of what,was
R6403 T8039 T8030 arg3Of ),(
R6404 T8059 T8061 arg1Of what,responsible
R6405 T8061 T8060 arg2Of responsible,was
R6406 T8042 T8043 arg1Of analysis,of
R6407 T8042 T8048 arg1Of analysis,confirmed
R6408 T8044 T8043 arg2Of cells,of
R6409 T8044 T8045 arg1Of cells,expressing
R6410 T8061 T8062 arg1Of responsible,for
R6411 T8047 T8045 arg2Of tagged-IKKγ,expressing
R6412 T8047 T8046 arg1Of tagged-IKKγ,epitope
R6413 T8066 T8062 arg2Of weight,for
R6414 T8048 T8040 arg1Of confirmed,Moreover
R6415 T8048 T8041 arg1Of confirmed,","
R6416 T8050 T8051 arg1Of recruitment,of
R6417 T8050 T8053 arg1Of recruitment,to
R6418 T8050 T8055 arg1Of recruitment,requires
R6419 T8052 T8051 arg2Of IKKγ,of
R6420 T8066 T8063 arg1Of weight,the
R6421 T8066 T8064 arg2Of weight,increased
R6422 T8066 T8065 arg1Of weight,molecular
R6423 T8066 T8067 arg1Of weight,of
R6424 T8066 T8069 arg1Of weight,in
R6425 T8068 T8067 arg2Of IKKγ,of
R6426 T8071 T8069 arg2Of immunoprecipitates,in
R6427 T8152 T8149 arg3Of phosphorylation,in
R6428 T8071 T8070 arg1Of immunoprecipitates,CD40
R6429 T8156 T8155 arg1Of data,these
R6430 T8156 T8157 arg1Of data,demonstrate
R6431 T8156 T8171 arg1Of data,suggest
R6432 T8157 T8170 arg1Of demonstrate,and
R6433 T8075 T8073 arg1Of samples,the
R6434 T8159 T8160 arg1Of HOIP,is
R6435 T8159 T8161 arg2Of HOIP,required
R6436 T8161 T8157 arg2Of required,demonstrate
R6437 T8161 T8158 arg1Of required,that
R6438 T8161 T8160 arg2Of required,is
R6439 T8161 T8162 arg1Of required,for
R6440 T8164 T8162 arg2Of association,for
R6441 T8164 T8163 arg1Of association,the
R6442 T8164 T8165 arg1Of association,of
R6443 T8164 T8167 arg1Of association,with
R6444 T8166 T8165 arg2Of IKKγ,of
R6445 T8075 T8074 arg1Of samples,protein
R6446 T8075 T8076 arg1Of samples,were
R6447 T8168 T8167 arg2Of CD40,with
R6448 T8075 T8077 arg2Of samples,incubated
R6449 T8077 T8057 modOf incubated,To
R6450 T8170 T8153 arg1Of and,Overall
R6451 T8170 T8154 arg1Of and,","
R6452 T8170 T8169 arg1Of and,","
R6453 T8171 T8170 arg2Of suggest,and
R6454 T8174 T8173 arg1Of event,this
R6455 T8174 T8175 arg1Of event,is
R6456 T8174 T8176 arg2Of event,coupled
R6457 T8077 T8072 arg1Of incubated,","
R6458 T8176 T8171 arg2Of coupled,suggest
R6459 T8176 T8172 arg1Of coupled,that
R6460 T8176 T8175 arg2Of coupled,is
R6461 T8176 T8177 arg1Of coupled,to
R6462 T8077 T8076 arg2Of incubated,were
R6463 T8077 T8078 arg1Of incubated,with
R6464 T8179 T8177 arg2Of modifications,to
R6465 T8179 T8178 arg1Of modifications,post-translational
R6466 T8179 T8180 arg1Of modifications,of
R6467 T8080 T8078 arg2Of phosphatase,with
R6468 T8181 T8180 arg2Of IKKγ,of
R6469 T8080 T8079 arg1Of phosphatase,lambda
R6470 T8080 T8081 arg1Of phosphatase,","
R6471 T8080 T8082 arg1Of phosphatase,which
R6472 T8080 T8083 arg1Of phosphatase,removes
R6473 T8084 T8083 arg2Of phosphates,removes
R6474 T8084 T8085 arg2Of phosphates,attached
R6475 T8085 T8086 arg1Of attached,to
R6477 T8087 T8088 arg1Of tyrosine,","
R6481 T8088 T8091 arg1Of ",",or
R6483 T8089 T8088 arg2Of threonine,","
R6484 T8091 T8086 arg2Of or,to
R6485 T8091 T8090 arg1Of or,","
R6486 T8091 T8094 arg1Of or,in
R6487 T8093 T8091 arg2Of residues,or
R6488 T8093 T8092 arg1Of residues,serine
R6489 T8095 T8094 arg2Of proteins,in
R6490 T8097 T8096 arg1Of treatment,This
R6491 T8097 T8098 arg1Of treatment,reduced
R6492 T8099 T8098 arg2Of much,reduced
R6493 T8099 T8100 arg1Of much,of
R6494 T8102 T8100 arg2Of IKKγ,of
R6495 T8102 T8101 arg1Of IKKγ,CD40-associated
R6496 T8102 T8103 arg1Of IKKγ,to
R6497 T8107 T8103 arg2Of weight,to
R6498 T8107 T8104 arg1Of weight,an
R6499 T8107 T8105 arg1Of weight,apparent
R6500 T8107 T8106 arg1Of weight,molecular
R6501 T8107 T8108 arg1Of weight,similar
R6502 T8108 T8109 arg1Of similar,to
R6503 T8108 T8114 arg1Of similar,in
R6504 T8110 T8109 arg2Of that,to
R6505 T8110 T8111 arg1Of that,of
R6506 T8113 T8111 arg2Of protein,of
R6507 T8113 T8112 arg1Of protein,the
R6508 T8116 T8114 arg2Of lysates,in
R6509 T8116 T8115 arg1Of lysates,cell
R6510 T8116 T8117 arg1Of lysates,(
R6511 T8119 T8117 arg2Of 5C,(
R6512 T8119 T8118 arg1Of 5C,Fig.
R6513 T8120 T8117 arg3Of ),(
R6514 T8125 T8123 arg1Of one,at
R6515 T8125 T8124 arg1Of one,least
R6516 T8126 T8125 arg1Of band,one
R6517 T8126 T8127 arg1Of band,of
R6518 T8126 T8132 arg1Of band,remained
R6519 T8126 T8133 arg1Of band,after
R6520 T8129 T8128 arg1Of higher,significantly
R6521 T8131 T8127 arg2Of weight,of
R6522 T8131 T8129 arg1Of weight,higher
R6523 T8131 T8130 arg1Of weight,molecular
R6524 T8132 T8121 arg1Of remained,However
R6525 T8132 T8122 arg1Of remained,","
R6526 T8132 T8136 arg1Of remained,","
R6527 T8132 T8137 modOf remained,suggesting
R6528 T8133 T8132 arg2Of after,remained
R6529 T8135 T8133 arg2Of treatment,after
R6530 T8135 T8134 arg1Of treatment,phosphatase
R6531 T8140 T8139 arg1Of IKKγ,CD40-associated
R6532 T8140 T8141 arg1Of IKKγ,is
R6533 T8140 T8142 arg1Of IKKγ,subject
R6534 T8141 T8137 arg2Of is,suggesting
R6535 T8141 T8138 arg1Of is,that
R6536 T8142 T8141 arg2Of subject,is
R6537 T8142 T8143 arg1Of subject,to
R6538 T8146 T8144 arg1Of one,at
R6539 T8146 T8145 arg1Of one,least
R6540 T8148 T8143 arg2Of modification,to
R6541 T8148 T8146 arg1Of modification,one
R6542 T8148 T8147 arg1Of modification,other
R6543 T8148 T8149 arg1Of modification,in
R6544 T8149 T8151 arg1Of in,to
R6545 T8150 T8149 arg2Of addition,in
R13634 T17282 T17281 arg1Of recruitment,IKK
R13635 T17282 T17283 arg1Of recruitment,to
R13636 T17282 T17288 arg1Of recruitment,is
R13637 T17282 T17289 arg1Of recruitment,defective
R13638 T17287 T17283 arg2Of complex,to
R13639 T17287 T17284 arg1Of complex,the
R13640 T17287 T17285 arg1Of complex,CD40
R13641 T17287 T17286 arg1Of complex,signaling
R13642 T17288 T17290 arg1Of is,in
R13643 T17289 T17288 arg2Of defective,is
R13644 T17292 T17290 arg2Of cells,in
R13645 T17292 T17291 arg1Of cells,HOIP-deficient
R13646 T17294 T17293 arg2Of A,(
R13647 T17295 T17293 arg3Of ),(
R13648 T17298 T17293 arg1Of treatment,(
R13649 T17298 T17296 arg1Of treatment,SMAC
R13650 T17298 T17297 arg1Of treatment,peptide
R13651 T17298 T17299 arg1Of treatment,reduces
R13652 T17298 T17306 arg1Of treatment,may
R13653 T17298 T17307 arg1Of treatment,modify
R13654 T17299 T17305 arg1Of reduces,and
R13655 T17300 T17299 arg2Of recruitment,reduces
R13656 T17300 T17301 arg1Of recruitment,of
R13657 T17300 T17303 arg1Of recruitment,to
R13658 T17302 T17301 arg2Of cIAP1,of
R13659 T17304 T17303 arg2Of CD40,to
R13660 T17307 T17305 arg2Of modify,and
R13661 T17307 T17306 arg2Of modify,may
R13662 T17309 T17307 arg2Of recruitment,modify
R13663 T17309 T17308 arg1Of recruitment,HOIP
R13664 T17311 T17310 arg1Of cells,A20.2J
R13665 T17311 T17312 arg1Of cells,were
R13666 T17311 T17313 arg2Of cells,incubated
R13667 T17313 T17312 arg2Of incubated,were
R13668 T17313 T17314 arg1Of incubated,for
R13669 T17316 T17314 arg2Of hours,for
R13670 T17316 T17315 arg1Of hours,six
R13671 T17316 T17317 arg1Of hours,with
R13672 T17320 T17318 arg1Of peptide,membrane-permeable
R13673 T17320 T17319 arg1Of peptide,SMAC-N7
R13674 T17320 T17321 arg1Of peptide,or
R13675 T17321 T17317 arg2Of or,with
R13676 T17322 T17323 arg1Of 1.5,%
R13677 T17324 T17321 arg2Of DMSO,or
R13678 T17324 T17322 arg1Of DMSO,1.5
R13679 T17324 T17325 arg1Of DMSO,(
R13680 T17326 T17325 arg2Of solvent,(
R13681 T17326 T17327 arg2Of solvent,used
R13682 T17327 T17328 arg1Of used,for
R13683 T17330 T17328 arg2Of peptide,for
R13684 T17330 T17329 arg1Of peptide,the
R13685 T17331 T17325 arg3Of ),(
R13686 T17334 T17332 arg2Of incubation,Following
R13687 T17334 T17333 arg1Of incubation,the
R13688 T17337 T17336 arg1Of lysates,cell
R13689 T17337 T17338 arg1Of lysates,were
R13690 T17337 T17339 arg2Of lysates,prepared
R13691 T17337 T17341 arg2Of lysates,fractionated
R13692 T17337 T17346 arg2Of lysates,evaluated
R13693 T17339 T17340 arg1Of prepared,","
R13694 T17340 T17345 arg1Of ",",and
R13695 T17341 T17340 arg2Of fractionated,","
R13696 T17343 T17341 arg1Of SDS-PAGE,fractionated
R13697 T17343 T17342 arg2Of SDS-PAGE,by
R13698 T17345 T17332 arg1Of and,Following
R13699 T17345 T17335 arg1Of and,","
R13700 T17345 T17338 arg2Of and,were
R13701 T17345 T17344 arg1Of and,","
R13702 T17346 T17345 arg2Of evaluated,and
R13703 T17349 T17346 arg1Of blot,evaluated
R13704 T17349 T17347 arg2Of blot,by
R13705 T17349 T17348 arg1Of blot,Western
R13706 T17349 T17350 arg1Of blot,(
R13707 T17352 T17353 arg1Of 1,and
R13708 T17353 T17350 arg2Of and,(
R13709 T17353 T17351 arg1Of and,lanes
R13710 T17354 T17353 arg2Of 2,and
R13711 T17355 T17350 arg3Of ),(
R13712 T17356 T17357 arg2Of Cells,incubated
R13713 T17356 T17362 arg1Of Cells,were
R13714 T17356 T17364 arg2Of Cells,stimulated
R13715 T17357 T17358 arg1Of incubated,with
R13716 T17359 T17360 arg1Of DMSO,or
R13717 T17360 T17358 arg2Of or,with
R13718 T17361 T17360 arg2Of SMAC-N7,or
R13719 T17364 T17362 arg2Of stimulated,were
R13720 T17364 T17363 arg1Of stimulated,also
R13721 T17364 T17365 arg1Of stimulated,with
R13722 T17367 T17365 arg2Of beads,with
R13723 T17367 T17366 arg1Of beads,magnetic
R13724 T17367 T17368 arg2Of beads,coated
R13725 T17368 T17369 arg1Of coated,with
R13726 T17370 T17371 arg1Of anti-CD40,or
R13727 T17371 T17369 arg2Of or,with
R13728 T17375 T17371 arg2Of antibody,or
R13729 T17375 T17372 arg1Of antibody,an
R13730 T17375 T17373 arg1Of antibody,isotype
R13731 T17375 T17374 arg1Of antibody,control
R13732 T17378 T17377 arg2Of IP,(
R13733 T17379 T17377 arg3Of ),(
R13734 T17380 T17376 arg2Of material,Immunoprecipitated
R13735 T17380 T17377 arg1Of material,(
R13736 T17380 T17381 arg2Of material,bound
R13737 T17380 T17385 arg1Of material,was
R13738 T17380 T17386 arg2Of material,loaded
R13739 T17381 T17382 arg1Of bound,to
R13740 T17384 T17382 arg2Of beads,to
R13741 T17384 T17383 arg1Of beads,the
R13742 T17386 T17385 arg2Of loaded,was
R13743 T17386 T17387 arg1Of loaded,in
R13744 T17388 T17387 arg2Of lanes,in
R13745 T17388 T17389 arg1Of lanes,3-5
R13746 T17390 T17391 arg1Of Samples,of
R13747 T17390 T17397 arg1Of Samples,appear
R13748 T17394 T17391 arg2Of lysates,of
R13749 T17394 T17392 arg1Of lysates,the
R13750 T17394 T17393 arg1Of lysates,cell
R13751 T17394 T17395 arg1Of lysates,after
R13752 T17396 T17395 arg2Of immunoprecipitation,after
R13753 T17397 T17398 arg1Of appear,in
R13754 T17399 T17398 arg2Of lanes,in
R13755 T17399 T17400 arg1Of lanes,6–8
R13756 T17402 T17401 arg1Of blots,Western
R13757 T17402 T17403 arg1Of blots,were
R13758 T17402 T17404 arg2Of blots,probed
R13759 T17404 T17403 arg2Of probed,were
R13760 T17404 T17405 arg1Of probed,with
R13761 T17406 T17405 arg2Of antibodies,with
R13762 T17406 T17407 arg1Of antibodies,specific
R13763 T17407 T17408 arg1Of specific,for
R13764 T17409 T17410 arg1Of cIAP1,","
R13765 T17410 T17412 arg1Of ",",","
R13766 T17411 T17410 arg2Of TRAF2,","
R13767 T17412 T17415 arg1Of ",",and
R13768 T17413 T17412 arg2Of TRAF3,","
R13769 T17415 T17408 arg2Of and,for
R13770 T17415 T17414 arg1Of and,","
R13771 T17416 T17415 arg2Of HOIP,and
R13772 T17416 T17417 arg1Of HOIP,(
R13773 T17420 T17418 arg1Of weights,approximate
R13774 T17420 T17419 arg1Of weights,molecular
R13775 T17420 T17421 arg1Of weights,indicated
R13776 T17421 T17417 arg2Of indicated,(
R13777 T17421 T17422 arg1Of indicated,on
R13778 T17423 T17422 arg2Of left,on
R13779 T17424 T17417 arg3Of ),(
R13780 T17426 T17425 arg1Of results,Similar
R13781 T17426 T17427 arg1Of results,were
R13782 T17426 T17428 arg2Of results,obtained
R13783 T17428 T17427 arg2Of obtained,were
R13784 T17428 T17429 arg1Of obtained,in
R13785 T17432 T17429 arg2Of experiments.,in
R13786 T17432 T17430 arg1Of experiments.,two
R13787 T17432 T17431 arg1Of experiments.,additional
R13788 T17432 T17433 arg1Of experiments.,(
R13789 T17432 T17454 arg2Of experiments.,transduced
R13790 T17434 T17433 arg2Of B,(
R13791 T17435 T17433 arg3Of ),(
R13792 T17436 T17437 arg1Of CD40,was
R13793 T17436 T17438 arg2Of CD40,isolated
R13794 T17438 T17437 arg2Of isolated,was
R13795 T17438 T17439 arg1Of isolated,by
R13796 T17440 T17439 arg2Of immunoprecipitation,by
R13797 T17440 T17441 arg1Of immunoprecipitation,(
R13798 T17440 T17448 arg1Of immunoprecipitation,from
R13799 T17443 T17441 arg2Of in,(
R13800 T17443 T17442 arg1Of in,as
R13801 T17445 T17443 arg2Of A,in
R13802 T17445 T17444 arg2Of A,(
R13803 T17446 T17444 arg3Of ),(
R13804 T17447 T17441 arg3Of ),(
R13805 T17450 T17449 arg1Of cells,A20.2J
R13806 T17450 T17451 arg1Of cells,and
R13807 T17451 T17448 arg2Of and,from
R13808 T17453 T17451 arg2Of cells,and
R13809 T17453 T17452 arg1Of cells,HOIP-deficient
R13810 T17454 T17437 modOf transduced,was
R13811 T17454 T17455 arg1Of transduced,with
R13812 T17459 T17456 arg1Of vector,an
R13813 T17459 T17457 arg1Of vector,empty
R13814 T17459 T17458 arg1Of vector,retroviral
R13815 T17459 T17460 arg1Of vector,(
R13816 T17459 T17463 arg1Of vector,or
R13817 T17461 T17460 arg2Of pMIP,(
R13818 T17462 T17460 arg3Of ),(
R13819 T17463 T17455 arg2Of or,with
R13820 T17466 T17463 arg2Of vector,or
R13821 T17466 T17464 arg1Of vector,a
R13822 T17466 T17465 arg1Of vector,retroviral
R13823 T17466 T17467 arg1Of vector,encoding
R13824 T17468 T17467 arg2Of HOIP,encoding
R13825 T17469 T17470 arg1Of Material,immunoprecipitated
R13826 T17470 T17471 arg1Of immunoprecipitated,with
R13827 T17470 T17479 arg1Of immunoprecipitated,or
R13828 T17475 T17471 arg2Of antibody,with
R13829 T17475 T17472 arg1Of antibody,an
R13830 T17475 T17473 arg1Of antibody,isotype
R13831 T17475 T17474 arg1Of antibody,control
R13832 T17475 T17476 arg1Of antibody,(
R13833 T17477 T17476 arg2Of isotype,(
R13834 T17478 T17476 arg3Of ),(
R13835 T17481 T17480 arg1Of antibody,anti-CD40
R13836 T17481 T17482 arg1Of antibody,was
R13837 T17481 T17483 arg2Of antibody,examined
R13838 T17483 T17479 arg2Of examined,or
R13839 T17483 T17482 arg2Of examined,was
R13840 T17486 T17483 arg1Of blotting,examined
R13841 T17486 T17484 arg2Of blotting,by
R13842 T17486 T17485 arg1Of blotting,Western
R13843 T17486 T17487 arg1Of blotting,for
R13844 T17488 T17489 arg1Of CD40,","
R13845 T17489 T17491 arg1Of ",",","
R13846 T17490 T17489 arg2Of TRAF2,","
R13847 T17491 T17493 arg1Of ",",","
R13848 T17492 T17491 arg2Of TRAF3,","
R13849 T17493 T17495 arg1Of ",",","
R13850 T17494 T17493 arg2Of cIAP1,","
R13851 T17495 T17497 arg1Of ",",","
R13852 T17496 T17495 arg2Of HOIP,","
R13853 T17497 T17500 arg1Of ",",and
R13854 T17498 T17497 arg2Of IKKα/β,","
R13855 T17500 T17487 arg2Of and,for
R13856 T17500 T17499 arg1Of and,","
R13857 T17501 T17500 arg2Of IKKγ,and
R13858 T17501 T17502 arg1Of IKKγ,(
R13859 T17504 T17502 arg2Of panels,(
R13860 T17504 T17503 arg1Of panels,right
R13861 T17505 T17502 arg3Of ),(
R13862 T17507 T17506 arg1Of expression,HOIP
R13863 T17507 T17508 arg1Of expression,was
R13864 T17507 T17509 arg2Of expression,required
R13865 T17509 T17508 arg2Of required,was
R13866 T17509 T17510 arg1Of required,for
R13867 T17511 T17510 arg2Of coprecipitation,for
R13868 T17511 T17512 arg1Of coprecipitation,of
R13869 T17514 T17512 arg2Of proteins,of
R13870 T17514 T17513 arg1Of proteins,IKK
R13871 T17514 T17515 arg1Of proteins,with
R13872 T17516 T17515 arg2Of CD40,with
R13873 T17518 T17517 arg1Of lysates,Cell
R13874 T17518 T17519 arg1Of lysates,from
R13875 T17518 T17522 arg1Of lysates,are
R13876 T17518 T17523 arg2Of lysates,shown
R13877 T17521 T17519 arg2Of cells,from
R13878 T17521 T17520 arg1Of cells,unstimulated
R13879 T17523 T17522 arg2Of shown,are
R13880 T17523 T17524 arg1Of shown,in
R13881 T17527 T17524 arg2Of panels,in
R13882 T17527 T17525 arg1Of panels,the
R13883 T17527 T17526 arg1Of panels,left
R13884 T17529 T17528 arg1Of results,Similar
R13885 T17529 T17530 arg1Of results,were
R13886 T17529 T17531 arg2Of results,obtained
R13887 T17531 T17530 arg2Of obtained,were
R13888 T17531 T17532 arg1Of obtained,in
R13889 T17531 T17537 arg1Of obtained,in
R13890 T17531 T17540 arg1Of obtained,with
R13891 T17532 T17536 arg1Of in,and
R13892 T17535 T17532 arg2Of experiment,in
R13893 T17535 T17533 arg1Of experiment,a
R13894 T17535 T17534 arg1Of experiment,second
R13895 T17537 T17536 arg2Of in,and
R13896 T17539 T17537 arg2Of experiments,in
R13897 T17539 T17538 arg1Of experiments,two
R13898 T17544 T17540 arg2Of clone.,with
R13899 T17544 T17541 arg1Of clone.,a
R13900 T17544 T17542 arg1Of clone.,second
R13901 T17544 T17543 arg1Of clone.,HOIP-deficient
R13902 T17544 T17545 arg1Of clone.,(
R13903 T17544 T17548 modOf clone.,To
R13904 T17546 T17545 arg2Of C,(
R13905 T17547 T17545 arg3Of ),(
R13906 T17550 T17548 arg1Of evaluate,To
R13907 T17550 T17549 arg1Of evaluate,further
R13908 T17552 T17550 arg2Of recruitment,evaluate
R13909 T17552 T17551 arg1Of recruitment,HOIP-dependent
R13910 T17552 T17553 arg1Of recruitment,of
R13911 T17552 T17555 arg1Of recruitment,to
R13912 T17554 T17553 arg2Of IKKγ,of
R13913 T17556 T17555 arg2Of CD40,to
R13914 T17559 T17558 arg1Of cells,A20.2J
R13915 T17559 T17560 arg1Of cells,or
R13916 T17560 T17567 arg1Of or,were
R13917 T17560 T17568 arg2Of or,transduced
R13918 T17561 T17562 arg1Of HOIP-deficient,(
R13919 T17563 T17562 arg2Of HOIP-/-,(
R13920 T17564 T17562 arg3Of ),(
R13921 T17566 T17560 arg2Of cells,or
R13922 T17566 T17561 arg1Of cells,HOIP-deficient
R13923 T17566 T17565 arg1Of cells,A20.2J
R13924 T17568 T17530 modOf transduced,were
R13925 T17568 T17557 arg1Of transduced,","
R13926 T17568 T17567 arg2Of transduced,were
R13927 T17568 T17569 arg1Of transduced,with
R13928 T17573 T17570 arg1Of vector,an
R13929 T17573 T17571 arg1Of vector,empty
R13930 T17573 T17572 arg1Of vector,retroviral
R13931 T17573 T17574 arg1Of vector,or
R13932 T17574 T17569 arg2Of or,with
R13933 T17577 T17574 arg2Of construct,or
R13934 T17577 T17575 arg1Of construct,a
R13935 T17577 T17576 arg1Of construct,retroviral
R13936 T17577 T17578 arg1Of construct,encoding
R13937 T17581 T17578 arg2Of IKKγ,encoding
R13938 T17581 T17579 arg1Of IKKγ,BP
R13939 T17581 T17580 arg1Of IKKγ,epitope-tagged
R13940 T17581 T17582 arg1Of IKKγ,(
R13941 T17583 T17582 arg2Of noted,(
R13942 T17583 T17584 arg1Of noted,in
R13943 T17583 T17587 arg1Of noted,as
R13944 T17583 T17591 arg1Of noted,","
R13945 T17583 T17592 arg1Of noted,respectively
R13946 T17586 T17584 arg2Of figure,in
R13947 T17586 T17585 arg1Of figure,the
R13948 T17588 T17589 arg1Of pMIP,and
R13949 T17589 T17587 arg2Of and,as
R13950 T17590 T17589 arg2Of IKKγ,and
R13951 T17593 T17582 arg3Of ),(
R13952 T17594 T17595 arg1Of Lysates,(
R13953 T17594 T17599 arg1Of Lysates,and
R13954 T17597 T17595 arg2Of 1–3,(
R13955 T17597 T17596 arg1Of 1–3,lanes
R13956 T17598 T17595 arg3Of ),(
R13957 T17599 T17609 arg1Of and,from
R13958 T17599 T17613 arg1Of and,were
R13959 T17599 T17614 arg2Of and,fractionated
R13960 T17599 T17618 arg2Of and,evaluated
R13961 T17602 T17601 arg2Of IP,(
R13962 T17603 T17601 arg3Of ),(
R13963 T17604 T17599 arg2Of samples,and
R13964 T17604 T17600 arg1Of samples,immunoprecipitation
R13965 T17604 T17601 arg1Of samples,(
R13966 T17604 T17605 arg1Of samples,(
R13967 T17606 T17605 arg2Of lanes,(
R13968 T17606 T17607 arg1Of lanes,4–11
R13969 T17608 T17605 arg3Of ),(
R13970 T17612 T17609 arg2Of lines,from
R13971 T17612 T17610 arg1Of lines,the
R13972 T17612 T17611 arg1Of lines,cell
R13973 T17614 T17615 arg1Of fractionated,by
R13974 T17614 T17617 arg1Of fractionated,and
R13975 T17616 T17615 arg2Of SDS-PAGE,by
R13976 T17617 T17613 arg2Of and,were
R13977 T17617 T17622 arg1Of and,with
R13978 T17618 T17617 arg2Of evaluated,and
R13979 T17621 T17614 arg1Of blotting,fractionated
R13980 T17621 T17618 arg1Of blotting,evaluated
R13981 T17621 T17619 arg2Of blotting,by
R13982 T17621 T17620 arg1Of blotting,Western
R13983 T17623 T17622 arg2Of antibodies,with
R13984 T17623 T17624 arg1Of antibodies,to
R13985 T17627 T17626 arg1Of tag,BP
R13986 T17627 T17628 arg1Of tag,(
R13987 T17627 T17634 arg1Of tag,and
R13988 T17629 T17628 arg2Of IKKγ,(
R13989 T17629 T17630 arg1Of IKKγ,","
R13990 T17632 T17630 arg2Of panel,","
R13991 T17632 T17631 arg1Of panel,upper
R13992 T17633 T17628 arg3Of ),(
R13993 T17634 T17624 arg2Of and,to
R13994 T17634 T17625 arg1Of and,the
R13995 T17635 T17634 arg2Of TRAF2,and
R13996 T17639 T17636 arg1Of sample,The
R13997 T17639 T17637 arg1Of sample,anti-CD40
R13998 T17639 T17638 arg1Of sample,IP
R13999 T17639 T17640 arg1Of sample,in
R14000 T17639 T17643 arg1Of sample,was
R14001 T17639 T17644 arg2Of sample,treated
R14002 T17641 T17640 arg2Of lane,in
R14003 T17641 T17642 arg1Of lane,11
R14004 T17644 T17643 arg2Of treated,was
R14005 T17644 T17645 arg1Of treated,with
R14006 T17644 T17648 arg1Of treated,;
R14007 T17647 T17645 arg2Of phosphatase,with
R14008 T17647 T17646 arg1Of phosphatase,λ
R14009 T17650 T17649 arg1Of sample,the
R14010 T17650 T17651 arg1Of sample,in
R14011 T17650 T17654 arg1Of sample,was
R14012 T17650 T17655 arg1Of sample,mock-treated
R14013 T17652 T17651 arg2Of lane,in
R14014 T17652 T17653 arg1Of lane,10
R14015 T17654 T17648 arg2Of was,;
R14016 T17655 T17654 arg2Of mock-treated,was
R14017 T17657 T17656 arg1Of samples,Protein
R14018 T17657 T17665 arg1Of samples,were
R14019 T17657 T17667 arg2Of samples,fractionated
R14020 T17660 T17661 arg1Of those,treated
R14021 T17661 T17658 arg2Of treated,(
R14022 T17661 T17659 arg1Of treated,minus
R14023 T17661 T17662 arg1Of treated,with
R14024 T17663 T17662 arg2Of phosphatase,with
R14025 T17664 T17658 arg3Of ),(
R14026 T17667 T17658 arg1Of fractionated,(
R14027 T17667 T17665 arg2Of fractionated,were
R14028 T17667 T17666 arg1Of fractionated,also
R14029 T17667 T17668 arg1Of fractionated,on
R14030 T17667 T17677 arg1Of fractionated,for
R14031 T17671 T17668 arg2Of gel,on
R14032 T17671 T17669 arg1Of gel,a
R14033 T17671 T17670 arg1Of gel,separate
R14034 T17671 T17672 arg1Of gel,(
R14035 T17675 T17672 arg2Of concentration,(
R14036 T17675 T17673 arg1Of concentration,lower
R14037 T17675 T17674 arg1Of concentration,acrylamide
R14038 T17676 T17672 arg3Of ),(
R14039 T17679 T17677 arg2Of evaluation,for
R14040 T17679 T17678 arg1Of evaluation,the
R14041 T17679 T17680 arg1Of evaluation,of
R14042 T17681 T17682 arg1Of TRAF3,and
R14043 T17682 T17680 arg2Of and,of
R14044 T17682 T17684 arg1Of and,(
R14045 T17683 T17682 arg2Of HOIP,and
R14046 T17687 T17684 arg2Of panels,(
R14047 T17687 T17685 arg1Of panels,bottom
R14048 T17687 T17686 arg1Of panels,two
R14049 T17688 T17684 arg3Of ),(
R14050 T17690 T17689 arg1Of results,Similar
R14051 T17690 T17691 arg1Of results,were
R14052 T17690 T17692 arg2Of results,obtained
R14053 T17692 T17691 arg2Of obtained,were
R14054 T17692 T17693 arg1Of obtained,in
R14055 T17696 T17693 arg2Of experiments,in
R14056 T17696 T17694 arg1Of experiments,two
R14057 T17696 T17695 arg1Of experiments,additional

2_test

Id Subject Object Predicate Lexical cue
21829693-20614026-89653769 438-439 20614026 denotes 6
21829693-21455173-89653770 577-579 21455173 denotes 14
21829693-14532003-89653771 807-809 14532003 denotes 15
21829693-20614026-89653772 4539-4540 20614026 denotes 6
21829693-20614026-89653773 5337-5338 20614026 denotes 6
T52587 438-439 20614026 denotes 6
T83759 577-579 21455173 denotes 14
T6761 807-809 14532003 denotes 15
T70732 4539-4540 20614026 denotes 6
T65429 5337-5338 20614026 denotes 6

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T6739 53-57 IN denotes with
T6740 58-62 NNP denotes CD40
T6741 63-66 NNP denotes The
T6742 67-73 VBD denotes marked
T6743 74-81 NNS denotes defects
T6744 82-84 IN denotes in
T6745 85-98 JJ denotes CD40-mediated
T6746 99-103 NN denotes cell
T6747 104-114 NN denotes activation
T6748 115-118 CC denotes and
T6749 119-128 VBG denotes signaling
T6750 129-138 VBN denotes displayed
T6751 139-141 IN denotes by
T6752 142-156 JJ denotes HOIP-deficient
T6753 157-162 NNS denotes cells
T6754 163-172 VBD denotes suggested
T6755 173-177 IN denotes that
T6756 178-182 NNP denotes HOIP
T6757 183-191 VBZ denotes mediates
T6758 192-203 NN denotes recruitment
T6759 204-206 IN denotes of
T6760 207-215 JJ denotes critical
T6761 216-226 NNS denotes components
T6762 227-229 IN denotes of
T6763 230-233 DT denotes the
T6764 234-238 NNP denotes CD40
T6765 239-248 VBG denotes signaling
T6766 249-258 NN denotes apparatus
T6767 259-261 TO denotes to
T6768 262-265 DT denotes the
T6769 266-274 NN denotes receptor
T6770 274-275 . denotes .
T6771 276-286 RB denotes Previously
T6772 286-287 , denotes ,
T6773 288-290 PRP denotes we
T6774 291-303 VBD denotes demonstrated
T6775 304-308 IN denotes that
T6776 309-313 NNP denotes HOIP
T6777 314-316 VBZ denotes is
T6778 317-326 VBN denotes recruited
T6779 327-329 TO denotes to
T6780 330-333 DT denotes the
T6781 334-338 NNP denotes CD40
T6782 339-348 VBG denotes signaling
T6783 349-356 JJ denotes complex
T6784 357-359 IN denotes in
T6785 360-361 DT denotes a
T6786 362-377 JJ denotes TRAF2-dependent
T6787 378-384 NN denotes manner
T6788 384-385 , denotes ,
T6789 386-396 VBG denotes suggesting
T6790 397-401 IN denotes that
T6791 402-406 NNP denotes HOIP
T6792 407-416 NNS denotes functions
T6793 417-427 JJ denotes downstream
T6794 428-430 IN denotes of
T6795 431-436 CD denotes TRAF2
T6796 437-438 NN denotes [
T6797 438-439 CD denotes 6
T6798 439-440 NNP denotes ]
T6799 440-441 . denotes .
T6800 442-449 NNS denotes Studies
T6801 450-452 IN denotes by
T6802 453-459 NNS denotes others
T6803 460-467 VBP denotes suggest
T6804 468-472 IN denotes that
T6805 473-476 DT denotes the
T6806 477-493 JJ denotes TRAF2-associated
T6807 494-502 NNS denotes proteins
T6808 503-508 JJ denotes cIAP1
T6809 509-512 CC denotes and
T6810 513-518 JJ denotes cIAP2
T6811 519-523 NN denotes play
T6812 524-525 DT denotes a
T6813 526-530 NN denotes role
T6814 531-533 IN denotes in
T6815 534-537 DT denotes the
T6816 538-549 NN denotes recruitment
T6817 550-552 IN denotes of
T6818 553-557 NNP denotes HOIP
T6819 558-560 TO denotes to
T6820 561-566 CD denotes TNFR1
T6821 567-570 CC denotes and
T6822 571-575 CD denotes CD40
T6823 576-577 NNP denotes [
T6824 577-579 CD denotes 14
T6825 579-580 NNP denotes ]
T6826 580-581 . denotes .
T6827 582-591 RB denotes Therefore
T6828 591-592 , denotes ,
T6829 593-595 PRP denotes we
T6830 596-606 VBD denotes determined
T6831 607-614 IN denotes whether
T6832 615-618 DT denotes the
T6833 619-630 NN denotes association
T6834 631-633 IN denotes of
T6835 634-638 NNP denotes HOIP
T6836 639-643 IN denotes with
T6837 644-648 NNP denotes CD40
T6838 649-651 IN denotes in
T6839 652-655 NNP denotes A20
T6840 655-657 CD denotes .2
T6841 657-658 NNP denotes J
T6842 659-664 NNS denotes cells
T6843 665-668 VBD denotes was
T6844 669-676 VBN denotes altered
T6845 677-679 IN denotes by
T6846 680-689 NN denotes treatment
T6847 690-692 IN denotes of
T6848 693-698 NNS denotes cells
T6849 699-703 IN denotes with
T6850 704-706 DT denotes an
T6851 707-716 NN denotes inhibitor
T6852 717-719 IN denotes of
T6853 720-724 JJ denotes cIAP
T6854 725-733 NN denotes activity
T6855 733-734 , denotes ,
T6856 735-736 DT denotes a
T6857 737-755 JJ denotes membrane-permeable
T6858 756-763 NN denotes peptide
T6859 764-771 VBN denotes derived
T6860 772-776 IN denotes from
T6861 777-780 DT denotes the
T6862 781-790 NN denotes apoptosis
T6863 791-800 NN denotes regulator
T6864 801-805 NNP denotes SMAC
T6865 806-807 NNP denotes [
T6866 807-809 CD denotes 15
T6867 809-810 NNP denotes ]
T6868 810-811 . denotes .
T6869 812-814 PRP denotes We
T6870 815-820 VBD denotes found
T6871 821-825 IN denotes that
T6872 826-838 NN denotes pretreatment
T6873 839-841 IN denotes of
T6874 842-847 NNS denotes cells
T6875 848-852 IN denotes with
T6876 853-856 DT denotes the
T6877 857-861 NNP denotes SMAC
T6878 862-869 NN denotes peptide
T6879 870-882 RB denotes dramatically
T6880 883-890 VBD denotes reduced
T6881 891-894 DT denotes the
T6882 895-901 NN denotes amount
T6883 902-904 IN denotes of
T6884 905-910 JJ denotes cIAP1
T6885 911-921 VBN denotes associated
T6886 922-926 IN denotes with
T6887 927-930 DT denotes the
T6888 931-935 NNP denotes CD40
T6889 936-945 VBG denotes signaling
T6890 946-953 JJ denotes complex
T6891 954-956 IN denotes in
T6892 957-962 NNS denotes cells
T6893 963-973 VBN denotes stimulated
T6894 974-978 IN denotes with
T6895 979-988 JJ denotes anti-CD40
T6896 989-1004 JJ denotes antibody-coated
T6897 1005-1010 NNS denotes beads
T6898 1011-1012 -LRB- denotes (
T6899 1012-1016 NNP denotes Fig.
T6900 1017-1019 NNP denotes 5A
T6901 1019-1020 -RRB- denotes )
T6902 1020-1021 . denotes .
T6903 1022-1026 NNP denotes SMAC
T6904 1027-1034 NN denotes peptide
T6905 1035-1044 NN denotes treatment
T6906 1045-1049 RB denotes also
T6907 1050-1058 VBD denotes resulted
T6908 1059-1061 IN denotes in
T6909 1062-1063 DT denotes a
T6910 1064-1070 JJ denotes slight
T6911 1071-1074 CC denotes but
T6912 1075-1087 JJ denotes reproducible
T6913 1088-1096 NN denotes decrease
T6914 1097-1099 IN denotes in
T6915 1100-1103 DT denotes the
T6916 1104-1110 NN denotes amount
T6917 1111-1113 IN denotes of
T6918 1114-1117 DT denotes the
T6919 1118-1123 JJ denotes major
T6920 1124-1128 NNP denotes HOIP
T6921 1129-1133 NN denotes form
T6922 1134-1143 VBD denotes recovered
T6923 1144-1146 IN denotes by
T6924 1147-1151 NNP denotes CD40
T6925 1152-1171 NN denotes immunoprecipitation
T6926 1171-1172 , denotes ,
T6927 1173-1178 IN denotes along
T6928 1179-1183 IN denotes with
T6929 1184-1186 DT denotes an
T6930 1187-1195 JJ denotes apparent
T6931 1196-1204 NN denotes increase
T6932 1205-1207 IN denotes in
T6933 1208-1214 JJR denotes higher
T6934 1215-1224 JJ denotes molecular
T6935 1225-1231 NN denotes weight
T6936 1232-1239 NNS denotes species
T6937 1240-1250 VBN denotes recognized
T6938 1251-1253 IN denotes by
T6939 1254-1263 JJ denotes anti-HOIP
T6940 1264-1272 NN denotes antibody
T6941 1272-1273 . denotes .
T6942 1274-1276 IN denotes In
T6943 1277-1285 NN denotes contrast
T6944 1285-1286 , denotes ,
T6945 1287-1296 NN denotes treatment
T6946 1297-1301 IN denotes with
T6947 1302-1305 DT denotes the
T6948 1306-1310 NNP denotes SMAC
T6949 1311-1318 NN denotes peptide
T6950 1319-1322 VBD denotes did
T6951 1323-1326 RB denotes not
T6952 1327-1332 VB denotes alter
T6953 1333-1336 DT denotes the
T6954 1337-1343 NN denotes amount
T6955 1344-1346 CC denotes or
T6956 1347-1356 JJ denotes molecular
T6957 1357-1363 NN denotes weight
T6958 1364-1366 IN denotes of
T6959 1367-1371 NNP denotes HOIP
T6960 1372-1379 NN denotes present
T6961 1380-1382 IN denotes in
T6962 1383-1387 NN denotes cell
T6963 1388-1395 NNS denotes lysates
T6964 1395-1396 . denotes .
T6965 1397-1402 DT denotes These
T6966 1403-1407 NNS denotes data
T6967 1408-1415 VBP denotes suggest
T6968 1416-1420 IN denotes that
T6969 1421-1425 NNP denotes SMAC
T6970 1426-1433 NN denotes peptide
T6971 1434-1443 NN denotes treatment
T6972 1444-1456 RB denotes specifically
T6973 1457-1463 VBZ denotes alters
T6974 1464-1467 DT denotes the
T6975 1468-1483 NNS denotes characteristics
T6976 1484-1486 IN denotes of
T6977 1487-1502 JJ denotes CD40-associated
T6978 1503-1507 NNP denotes HOIP
T6979 1508-1514 RB denotes rather
T6980 1515-1519 IN denotes than
T6981 1520-1523 DT denotes the
T6982 1524-1530 JJ denotes entire
T6983 1531-1539 JJ denotes cellular
T6984 1540-1544 NN denotes pool
T6985 1545-1547 IN denotes of
T6986 1548-1552 DT denotes this
T6987 1553-1560 NN denotes protein
T6988 1560-1561 . denotes .
T6989 1562-1570 RB denotes Together
T6990 1570-1571 , denotes ,
T6991 1572-1577 DT denotes these
T6992 1578-1585 NNS denotes results
T6993 1586-1593 VBP denotes support
T6994 1594-1597 DT denotes the
T6995 1598-1602 NN denotes idea
T6996 1603-1607 IN denotes that
T6997 1608-1611 DT denotes the
T6998 1612-1616 NNP denotes cIAP
T6999 1617-1625 NNS denotes proteins
T7000 1626-1635 VBP denotes influence
T7001 1636-1639 DT denotes the
T7002 1640-1651 NN denotes recruitment
T7003 1652-1655 CC denotes and
T7004 1656-1674 JJ denotes post-translational
T7005 1675-1687 NN denotes modification
T7006 1688-1693 NN denotes state
T7007 1694-1696 IN denotes of
T7008 1697-1712 JJ denotes CD40-associated
T7009 1713-1717 NNP denotes HOIP
T7010 1717-1718 . denotes .
T7011 4172-4174 TO denotes To
T7012 4175-4179 VB denotes test
T7013 4180-4183 DT denotes the
T7014 4184-4195 NN denotes possibility
T7015 4196-4200 WDT denotes that
T7016 4201-4205 NNP denotes HOIP
T7017 4206-4208 VBZ denotes is
T7018 4209-4220 JJ denotes responsible
T7019 4221-4224 IN denotes for
T7020 4225-4228 DT denotes the
T7021 4229-4240 NN denotes recruitment
T7022 4241-4243 IN denotes of
T7023 4244-4249 JJ denotes other
T7024 4250-4258 JJ denotes critical
T7025 4259-4268 VBG denotes signaling
T7026 4269-4277 NNS denotes proteins
T7027 4278-4280 TO denotes to
T7028 4281-4285 NNP denotes CD40
T7029 4285-4286 , denotes ,
T7030 4287-4289 PRP denotes we
T7031 4290-4308 VBD denotes immunoprecipitated
T7032 4309-4313 NNP denotes CD40
T7033 4314-4323 VBG denotes signaling
T7034 4324-4333 NNS denotes complexes
T7035 4334-4338 IN denotes from
T7036 4339-4353 JJ denotes HOIP-deficient
T7037 4354-4357 CC denotes and
T7038 4358-4376 JJ denotes HOIP-reconstituted
T7039 4377-4382 NNS denotes cells
T7040 4383-4384 -LRB- denotes (
T7041 4384-4388 NNP denotes Fig.
T7042 4389-4391 NNP denotes 5B
T7043 4391-4392 -RRB- denotes )
T7044 4392-4393 . denotes .
T7045 4394-4396 IN denotes As
T7046 4397-4406 VBN denotes described
T7047 4407-4417 RB denotes previously
T7048 4417-4418 , denotes ,
T7049 4419-4423 NNP denotes CD40
T7050 4424-4433 VBG denotes signaling
T7051 4434-4443 NNS denotes complexes
T7052 4444-4462 VBN denotes immunoprecipitated
T7053 4463-4467 IN denotes from
T7054 4468-4471 CD denotes A20
T7055 4471-4473 CD denotes .2
T7056 4473-4474 NNP denotes J
T7057 4475-4480 NNS denotes cells
T7058 4481-4490 VBD denotes contained
T7059 4491-4495 NNP denotes HOIP
T7060 4496-4498 RB denotes as
T7061 4499-4503 RB denotes well
T7062 4504-4506 IN denotes as
T7063 4507-4512 CD denotes TRAF2
T7064 4512-4513 , denotes ,
T7065 4514-4519 CD denotes TRAF3
T7066 4519-4520 , denotes ,
T7067 4521-4525 NNP denotes IKKα
T7068 4525-4526 NNP denotes /
T7069 4526-4527 NN denotes β
T7070 4527-4528 , denotes ,
T7071 4529-4532 CC denotes and
T7072 4533-4537 NNP denotes IKKγ
T7073 4538-4539 NNP denotes [
T7074 4539-4540 CD denotes 6
T7075 4540-4541 NNP denotes ]
T7076 4541-4542 . denotes .
T7077 4543-4546 DT denotes The
T7078 4547-4554 NNS denotes amounts
T7079 4555-4557 IN denotes of
T7080 4558-4563 CD denotes TRAF2
T7081 4563-4564 , denotes ,
T7082 4565-4570 CD denotes TRAF3
T7083 4570-4571 , denotes ,
T7084 4572-4575 CC denotes and
T7085 4576-4581 NNP denotes cIAP1
T7086 4582-4584 IN denotes in
T7087 4585-4589 NNP denotes CD40
T7088 4590-4608 VBZ denotes immunoprecipitates
T7089 4609-4613 IN denotes from
T7090 4614-4628 JJ denotes HOIP-deficient
T7091 4629-4634 NNS denotes cells
T7092 4635-4639 VBD denotes were
T7093 4640-4647 JJ denotes similar
T7094 4648-4650 TO denotes to
T7095 4651-4656 DT denotes those
T7096 4657-4661 IN denotes from
T7097 4662-4670 JJ denotes parental
T7098 4671-4674 NNP denotes A20
T7099 4674-4676 CD denotes .2
T7100 4676-4677 NNP denotes J
T7101 4678-4683 NNS denotes cells
T7102 4683-4684 , denotes ,
T7103 4685-4695 VBG denotes indicating
T7104 4696-4700 IN denotes that
T7105 4701-4705 NNP denotes HOIP
T7106 4706-4708 VBZ denotes is
T7107 4709-4712 RB denotes not
T7108 4713-4721 VBN denotes required
T7109 4722-4725 IN denotes for
T7110 4726-4729 DT denotes the
T7111 4730-4741 NN denotes association
T7112 4742-4744 IN denotes of
T7113 4745-4750 DT denotes these
T7114 4751-4759 NNS denotes proteins
T7115 4760-4764 IN denotes with
T7116 4765-4769 NNP denotes CD40
T7117 4769-4770 . denotes .
T7118 4771-4773 IN denotes In
T7119 4774-4782 NN denotes contrast
T7120 4782-4783 , denotes ,
T7121 4784-4788 NNP denotes IKKα
T7122 4788-4789 NNP denotes /
T7123 4789-4790 NN denotes β
T7124 4791-4794 CC denotes and
T7125 4795-4799 NNP denotes IKKγ
T7126 4800-4804 VBD denotes were
T7127 4805-4808 RB denotes not
T7128 4809-4819 JJ denotes detectable
T7129 4820-4822 IN denotes in
T7130 4823-4827 CD denotes CD40
T7131 4828-4846 NNS denotes immunoprecipitates
T7132 4847-4856 VBD denotes recovered
T7133 4857-4861 IN denotes from
T7134 4862-4876 JJ denotes HOIP-deficient
T7135 4877-4882 NNS denotes cells
T7136 4883-4884 -LRB- denotes (
T7137 4884-4888 NNP denotes Fig.
T7138 4889-4891 NNP denotes 5B
T7139 4891-4892 , denotes ,
T7140 4892-4893 NNP denotes C
T7141 4893-4894 -RRB- denotes )
T7142 4894-4895 . denotes .
T7143 4896-4899 DT denotes The
T7144 4900-4907 NNS denotes amounts
T7145 4908-4910 IN denotes of
T7146 4911-4915 NNP denotes IKKα
T7147 4915-4916 NNP denotes /
T7148 4916-4917 NN denotes β
T7149 4918-4921 CC denotes and
T7150 4922-4926 NNP denotes IKKγ
T7151 4927-4929 IN denotes in
T7152 4930-4934 NNP denotes CD40
T7153 4935-4953 VBZ denotes immunoprecipitates
T7154 4954-4958 IN denotes from
T7155 4959-4977 JJ denotes HOIP-reconstituted
T7156 4978-4983 NNS denotes cells
T7157 4984-4988 VBD denotes were
T7158 4989-4996 JJ denotes similar
T7159 4997-4999 TO denotes to
T7160 5000-5005 DT denotes those
T7161 5006-5014 VBN denotes detected
T7162 5015-5017 IN denotes in
T7163 5018-5025 NNS denotes samples
T7164 5026-5034 VBN denotes prepared
T7165 5035-5039 IN denotes from
T7166 5040-5048 JJ denotes parental
T7167 5049-5054 NNS denotes cells
T7168 5054-5055 , denotes ,
T7169 5056-5069 VBG denotes demonstrating
T7170 5070-5074 IN denotes that
T7171 5075-5078 DT denotes the
T7172 5079-5086 NNS denotes defects
T7173 5087-5089 IN denotes in
T7174 5090-5093 NNP denotes IKK
T7175 5094-5105 NN denotes recruitment
T7176 5106-5108 PRP denotes we
T7177 5109-5117 VBD denotes observed
T7178 5118-5122 VBD denotes were
T7179 5123-5126 JJ denotes due
T7180 5127-5139 RB denotes specifically
T7181 5140-5142 TO denotes to
T7182 5143-5146 DT denotes the
T7183 5147-5154 NN denotes absence
T7184 5155-5157 IN denotes of
T7185 5158-5162 NNP denotes HOIP
T7186 5163-5173 NN denotes expression
T7187 5173-5174 . denotes .
T7188 5175-5180 DT denotes These
T7189 5181-5185 NNS denotes data
T7190 5186-5194 VBP denotes indicate
T7191 5195-5199 IN denotes that
T7192 5200-5204 NNP denotes HOIP
T7193 5205-5207 VBZ denotes is
T7194 5208-5216 VBN denotes required
T7195 5217-5220 IN denotes for
T7196 5221-5232 NN denotes recruitment
T7197 5233-5235 IN denotes of
T7198 5236-5239 DT denotes the
T7199 5240-5256 JJ denotes NF-κB-activating
T7200 5257-5264 NN denotes complex
T7201 5265-5267 TO denotes to
T7202 5268-5271 DT denotes the
T7203 5272-5276 NNP denotes CD40
T7204 5277-5286 VBG denotes signaling
T7205 5287-5294 NN denotes complex
T7206 5294-5295 . denotes .
T7207 5296-5298 IN denotes As
T7208 5299-5304 VBN denotes shown
T7209 5305-5309 RB denotes here
T7210 5310-5313 CC denotes and
T7211 5314-5316 IN denotes in
T7212 5317-5320 PRP$ denotes our
T7213 5321-5329 JJ denotes previous
T7214 5330-5335 NN denotes study
T7215 5336-5337 NN denotes [
T7216 5337-5338 CD denotes 6
T7217 5338-5339 NNP denotes ]
T7218 5339-5340 , denotes ,
T7219 5341-5345 NNP denotes IKKγ
T7220 5346-5353 NN denotes present
T7221 5354-5356 IN denotes in
T7222 5357-5361 NNP denotes CD40
T7223 5362-5380 VBZ denotes immunoprecipitates
T7224 5381-5388 VBZ denotes appears
T7225 5389-5391 TO denotes to
T7226 5392-5396 VB denotes have
T7227 5397-5398 DT denotes a
T7228 5399-5405 JJR denotes higher
T7229 5406-5415 JJ denotes molecular
T7230 5416-5422 NN denotes weight
T7231 5423-5427 IN denotes than
T7232 5428-5432 DT denotes that
T7233 5433-5438 VBN denotes found
T7234 5439-5441 IN denotes in
T7235 5442-5446 NN denotes cell
T7236 5447-5454 NNS denotes lysates
T7237 5454-5455 . denotes .
T7238 5456-5458 TO denotes To
T7239 5459-5466 VB denotes confirm
T7240 5467-5471 IN denotes that
T7241 5472-5476 DT denotes this
T7242 5477-5483 JJR denotes higher
T7243 5484-5493 JJ denotes molecular
T7244 5494-5500 NN denotes weight
T7245 5501-5508 NNS denotes species
T7246 5509-5512 VBD denotes was
T7247 5513-5519 RB denotes indeed
T7248 5520-5524 NNP denotes IKKγ
T7249 5524-5525 , denotes ,
T7250 5526-5528 PRP denotes we
T7251 5529-5538 VBD denotes generated
T7252 5539-5542 NNP denotes A20
T7253 5542-5544 CD denotes .2
T7254 5544-5545 NNP denotes J
T7255 5546-5550 NN denotes cell
T7256 5551-5556 NNS denotes lines
T7257 5557-5567 VBG denotes containing
T7258 5568-5569 DT denotes a
T7259 5570-5576 RB denotes stably
T7260 5577-5587 VBN denotes integrated
T7261 5588-5598 JJ denotes retroviral
T7262 5599-5605 NN denotes vector
T7263 5606-5610 WDT denotes that
T7264 5611-5618 VBD denotes encoded
T7265 5619-5621 DT denotes an
T7266 5622-5636 JJ denotes epitope-tagged
T7267 5637-5644 NN denotes version
T7268 5645-5647 IN denotes of
T7269 5648-5653 NN denotes mouse
T7270 5654-5658 NNP denotes IKKγ
T7271 5658-5659 . denotes .
T7272 5660-5664 NN denotes Cell
T7273 5665-5672 NNS denotes lysates
T7274 5673-5676 CC denotes and
T7275 5677-5681 JJ denotes CD40
T7276 5682-5700 NNS denotes immunoprecipitates
T7277 5701-5709 VBN denotes prepared
T7278 5710-5714 IN denotes from
T7279 5715-5720 DT denotes these
T7280 5721-5726 NNS denotes cells
T7281 5727-5731 VBD denotes were
T7282 5732-5740 VBN denotes analyzed
T7283 5741-5743 IN denotes by
T7284 5744-5751 JJ denotes Western
T7285 5752-5760 VBG denotes blotting
T7286 5761-5764 IN denotes for
T7287 5765-5768 DT denotes the
T7288 5769-5776 NN denotes epitope
T7289 5777-5780 NN denotes tag
T7290 5781-5782 -LRB- denotes (
T7291 5782-5786 NNP denotes Fig.
T7292 5787-5789 NNP denotes 5C
T7293 5789-5790 -RRB- denotes )
T7294 5790-5791 . denotes .
T7295 5792-5796 DT denotes This
T7296 5797-5805 NN denotes analysis
T7297 5806-5814 VBD denotes produced
T7298 5815-5816 DT denotes a
T7299 5817-5824 NN denotes pattern
T7300 5825-5827 IN denotes of
T7301 5828-5833 NNS denotes bands
T7302 5834-5838 WDT denotes that
T7303 5839-5842 VBD denotes was
T7304 5843-5854 RB denotes essentially
T7305 5855-5858 DT denotes the
T7306 5859-5863 JJ denotes same
T7307 5864-5866 IN denotes as
T7308 5867-5871 DT denotes that
T7309 5872-5880 VBN denotes obtained
T7310 5881-5886 VBG denotes using
T7311 5887-5889 DT denotes an
T7312 5890-5898 NN denotes antibody
T7313 5899-5907 NN denotes specific
T7314 5908-5911 IN denotes for
T7315 5912-5918 JJ denotes native
T7316 5919-5923 NNP denotes IKKγ
T7317 5924-5925 -LRB- denotes (
T7318 5925-5932 VB denotes compare
T7319 5933-5939 NNS denotes panels
T7320 5940-5941 NNP denotes B
T7321 5942-5945 CC denotes and
T7322 5946-5947 NNP denotes C
T7323 5948-5950 IN denotes in
T7324 5951-5955 NNP denotes Fig.
T7325 5956-5957 CD denotes 5
T7326 5957-5958 -RRB- denotes )
T7327 5958-5959 . denotes .
T7328 5960-5968 RB denotes Moreover
T7329 5968-5969 , denotes ,
T7330 5970-5978 NN denotes analysis
T7331 5979-5981 IN denotes of
T7332 5982-5987 NNS denotes cells
T7333 5988-5998 VBG denotes expressing
T7334 5999-6006 NN denotes epitope
T7335 6007-6018 NN denotes tagged-IKKγ
T7336 6019-6028 VBD denotes confirmed
T7337 6029-6033 IN denotes that
T7338 6034-6045 NN denotes recruitment
T7339 6046-6048 IN denotes of
T7340 6049-6053 NNP denotes IKKγ
T7341 6054-6056 TO denotes to
T7342 6057-6061 NNP denotes CD40
T7343 6062-6070 VBZ denotes requires
T7344 6071-6075 NNP denotes HOIP
T7345 6075-6076 . denotes .
T7346 6077-6079 TO denotes To
T7347 6080-6089 VB denotes determine
T7348 6090-6094 WP denotes what
T7349 6095-6098 VBD denotes was
T7350 6099-6110 JJ denotes responsible
T7351 6111-6114 IN denotes for
T7352 6115-6118 DT denotes the
T7353 6119-6128 VBN denotes increased
T7354 6129-6138 JJ denotes molecular
T7355 6139-6145 NN denotes weight
T7356 6146-6148 IN denotes of
T7357 6149-6153 NNP denotes IKKγ
T7358 6154-6156 IN denotes in
T7359 6157-6161 NNP denotes CD40
T7360 6162-6180 NNS denotes immunoprecipitates
T7361 6180-6181 , denotes ,
T7362 6182-6185 DT denotes the
T7363 6186-6193 NN denotes protein
T7364 6194-6201 NNS denotes samples
T7365 6202-6206 VBD denotes were
T7366 6207-6216 VBN denotes incubated
T7367 6217-6221 IN denotes with
T7368 6222-6228 JJ denotes lambda
T7369 6229-6240 NN denotes phosphatase
T7370 6240-6241 , denotes ,
T7371 6242-6247 WDT denotes which
T7372 6248-6255 VBZ denotes removes
T7373 6256-6266 NNS denotes phosphates
T7374 6267-6275 VBN denotes attached
T7375 6276-6278 TO denotes to
T7376 6279-6287 VB denotes tyrosine
T7377 6287-6288 , denotes ,
T7378 6289-6298 NN denotes threonine
T7379 6298-6299 , denotes ,
T7380 6300-6302 CC denotes or
T7381 6303-6309 NN denotes serine
T7382 6310-6318 NNS denotes residues
T7383 6319-6321 IN denotes in
T7384 6322-6330 NNS denotes proteins
T7385 6330-6331 . denotes .
T7386 6332-6336 DT denotes This
T7387 6337-6346 NN denotes treatment
T7388 6347-6354 VBN denotes reduced
T7389 6355-6359 RB denotes much
T7390 6360-6362 IN denotes of
T7391 6363-6378 JJ denotes CD40-associated
T7392 6379-6383 NNP denotes IKKγ
T7393 6384-6386 TO denotes to
T7394 6387-6389 DT denotes an
T7395 6390-6398 JJ denotes apparent
T7396 6399-6408 JJ denotes molecular
T7397 6409-6415 NN denotes weight
T7398 6416-6423 JJ denotes similar
T7399 6424-6426 TO denotes to
T7400 6427-6431 DT denotes that
T7401 6432-6434 IN denotes of
T7402 6435-6438 DT denotes the
T7403 6439-6446 NN denotes protein
T7404 6447-6449 IN denotes in
T7405 6450-6454 NN denotes cell
T7406 6455-6462 NNS denotes lysates
T7407 6463-6464 -LRB- denotes (
T7408 6464-6468 NNP denotes Fig.
T7409 6469-6471 NNP denotes 5C
T7410 6471-6472 -RRB- denotes )
T7411 6472-6473 . denotes .
T7412 6474-6481 RB denotes However
T7413 6481-6482 , denotes ,
T7414 6483-6485 IN denotes at
T7415 6486-6491 JJS denotes least
T7416 6492-6495 CD denotes one
T7417 6496-6500 NN denotes band
T7418 6501-6503 IN denotes of
T7419 6504-6517 RB denotes significantly
T7420 6518-6524 JJR denotes higher
T7421 6525-6534 JJ denotes molecular
T7422 6535-6541 NN denotes weight
T7423 6542-6550 VBD denotes remained
T7424 6551-6556 IN denotes after
T7425 6557-6568 NN denotes phosphatase
T7426 6569-6578 NN denotes treatment
T7427 6578-6579 , denotes ,
T7428 6580-6590 VBG denotes suggesting
T7429 6591-6595 IN denotes that
T7430 6596-6611 JJ denotes CD40-associated
T7431 6612-6616 NNP denotes IKKγ
T7432 6617-6619 VBZ denotes is
T7433 6620-6627 JJ denotes subject
T7434 6628-6630 TO denotes to
T7435 6631-6633 IN denotes at
T7436 6634-6639 JJS denotes least
T7437 6640-6643 CD denotes one
T7438 6644-6649 JJ denotes other
T7439 6650-6662 NN denotes modification
T7440 6663-6665 IN denotes in
T7441 6666-6674 NN denotes addition
T7442 6675-6677 TO denotes to
T7443 6678-6693 NN denotes phosphorylation
T7444 6693-6694 . denotes .
T7445 6695-6702 RB denotes Overall
T7446 6702-6703 , denotes ,
T7447 6704-6709 DT denotes these
T7448 6710-6714 NNS denotes data
T7449 6715-6726 VBP denotes demonstrate
T7450 6727-6731 IN denotes that
T7451 6732-6736 NNP denotes HOIP
T7452 6737-6739 VBZ denotes is
T7453 6740-6748 VBN denotes required
T7454 6749-6752 IN denotes for
T7455 6753-6756 DT denotes the
T7456 6757-6768 NN denotes association
T7457 6769-6771 IN denotes of
T7458 6772-6776 NNP denotes IKKγ
T7459 6777-6781 IN denotes with
T7460 6782-6786 NNP denotes CD40
T7461 6786-6787 , denotes ,
T7462 6788-6791 CC denotes and
T7463 6792-6799 VBP denotes suggest
T7464 6800-6804 IN denotes that
T7465 6805-6809 DT denotes this
T7466 6810-6815 NN denotes event
T7467 6816-6818 VBZ denotes is
T7468 6819-6826 VBN denotes coupled
T7469 6827-6829 TO denotes to
T7470 6830-6848 JJ denotes post-translational
T7471 6849-6862 NNS denotes modifications
T7472 6863-6865 IN denotes of
T7473 6866-6870 NNP denotes IKKγ
T7474 6870-6871 . denotes .
T16830 1763-1766 NNP denotes IKK
T16831 1767-1778 NN denotes recruitment
T16832 1779-1781 TO denotes to
T16833 1782-1785 DT denotes the
T16834 1786-1790 NNP denotes CD40
T16835 1791-1800 VBG denotes signaling
T16836 1801-1808 NN denotes complex
T16837 1809-1811 VBZ denotes is
T16838 1812-1821 JJ denotes defective
T16839 1822-1824 IN denotes in
T16840 1825-1839 JJ denotes HOIP-deficient
T16841 1840-1845 NNS denotes cells
T16842 1845-1846 . denotes .
T16843 1847-1848 -LRB- denotes (
T16844 1848-1849 NNP denotes A
T16845 1849-1850 -RRB- denotes )
T16846 1851-1855 NNP denotes SMAC
T16847 1856-1863 NN denotes peptide
T16848 1864-1873 NN denotes treatment
T16849 1874-1881 VBZ denotes reduces
T16850 1882-1893 NN denotes recruitment
T16851 1894-1896 IN denotes of
T16852 1897-1902 NNP denotes cIAP1
T16853 1903-1905 TO denotes to
T16854 1906-1910 NNP denotes CD40
T16855 1911-1914 CC denotes and
T16856 1915-1918 MD denotes may
T16857 1919-1925 VB denotes modify
T16858 1926-1930 NNP denotes HOIP
T16859 1931-1942 NN denotes recruitment
T16860 1942-1943 . denotes .
T16861 1944-1947 CD denotes A20
T16862 1947-1949 CD denotes .2
T16863 1949-1950 NNP denotes J
T16864 1951-1956 NNS denotes cells
T16865 1957-1961 VBD denotes were
T16866 1962-1971 VBN denotes incubated
T16867 1972-1975 IN denotes for
T16868 1976-1979 CD denotes six
T16869 1980-1985 NNS denotes hours
T16870 1986-1990 IN denotes with
T16871 1991-2009 JJ denotes membrane-permeable
T16872 2010-2017 NNP denotes SMAC-N7
T16873 2018-2025 NN denotes peptide
T16874 2026-2028 CC denotes or
T16875 2029-2032 CD denotes 1.5
T16876 2032-2033 NN denotes %
T16877 2034-2038 NNP denotes DMSO
T16878 2039-2040 -LRB- denotes (
T16879 2040-2047 JJ denotes solvent
T16880 2048-2052 VBN denotes used
T16881 2053-2056 IN denotes for
T16882 2057-2060 DT denotes the
T16883 2061-2068 NN denotes peptide
T16884 2068-2069 -RRB- denotes )
T16885 2069-2070 . denotes .
T16886 2071-2080 VBG denotes Following
T16887 2081-2084 DT denotes the
T16888 2085-2095 NN denotes incubation
T16889 2095-2096 , denotes ,
T16890 2097-2101 NN denotes cell
T16891 2102-2109 NNS denotes lysates
T16892 2110-2114 VBD denotes were
T16893 2115-2123 VBN denotes prepared
T16894 2123-2124 , denotes ,
T16895 2125-2137 VBN denotes fractionated
T16896 2138-2140 IN denotes by
T16897 2141-2149 NNP denotes SDS-PAGE
T16898 2149-2150 , denotes ,
T16899 2151-2154 CC denotes and
T16900 2155-2164 VBN denotes evaluated
T16901 2165-2167 IN denotes by
T16902 2168-2175 JJ denotes Western
T16903 2176-2180 NN denotes blot
T16904 2181-2182 -LRB- denotes (
T16905 2182-2187 NNS denotes lanes
T16906 2188-2189 CD denotes 1
T16907 2190-2193 CC denotes and
T16908 2194-2195 CD denotes 2
T16909 2195-2196 -RRB- denotes )
T16910 2196-2197 . denotes .
T16911 2198-2203 NNS denotes Cells
T16912 2204-2213 VBD denotes incubated
T16913 2214-2218 IN denotes with
T16914 2219-2223 NNP denotes DMSO
T16915 2224-2226 CC denotes or
T16916 2227-2234 NNP denotes SMAC-N7
T16918 2240-2244 RB denotes also
T16919 2245-2255 VBN denotes stimulated
T16920 2256-2260 IN denotes with
T16921 2261-2269 JJ denotes magnetic
T16922 2270-2275 NNS denotes beads
T16923 2276-2282 VBN denotes coated
T16924 2283-2287 IN denotes with
T16925 2288-2297 JJ denotes anti-CD40
T16926 2790-2794 IN denotes with
T16927 2298-2300 CC denotes or
T16928 2301-2303 DT denotes an
T16929 2304-2311 NN denotes isotype
T16930 2312-2319 NN denotes control
T16931 2320-2328 NN denotes antibody
T16932 2328-2329 . denotes .
T16933 2330-2348 VBN denotes Immunoprecipitated
T16934 2349-2350 -LRB- denotes (
T16935 2350-2352 NNP denotes IP
T16936 2352-2353 -RRB- denotes )
T16937 2354-2362 NN denotes material
T16938 2363-2368 VBN denotes bound
T16939 2369-2371 TO denotes to
T16940 2372-2375 DT denotes the
T16941 2376-2381 NNS denotes beads
T16942 2382-2385 VBD denotes was
T16943 2386-2392 VBN denotes loaded
T16944 2393-2395 IN denotes in
T16945 2396-2401 NNS denotes lanes
T16946 2402-2405 CD denotes 3-5
T16947 2405-2406 . denotes .
T16948 2407-2414 NNS denotes Samples
T16949 2415-2417 IN denotes of
T16950 2418-2421 DT denotes the
T16951 2422-2426 NN denotes cell
T16952 2427-2434 VBZ denotes lysates
T16953 2435-2440 IN denotes after
T16954 2441-2460 NN denotes immunoprecipitation
T16955 2461-2467 VBP denotes appear
T16956 2468-2470 IN denotes in
T16957 2471-2476 NNS denotes lanes
T16958 2477-2478 CD denotes 6
T16959 2479-2480 CD denotes 8
T16960 2480-2481 . denotes .
T16961 2482-2489 JJ denotes Western
T16962 2490-2495 NNS denotes blots
T16963 2496-2500 VBD denotes were
T16964 2501-2507 VBN denotes probed
T16965 2508-2512 IN denotes with
T16966 2513-2523 NNS denotes antibodies
T16967 2524-2532 JJ denotes specific
T16968 2533-2536 IN denotes for
T16969 2537-2542 NNP denotes cIAP1
T16970 2542-2543 , denotes ,
T16971 2544-2549 CD denotes TRAF2
T16972 2549-2550 , denotes ,
T16973 2551-2556 CD denotes TRAF3
T16974 2556-2557 , denotes ,
T16975 2558-2561 CC denotes and
T16976 2562-2566 NNP denotes HOIP
T16977 2567-2568 -LRB- denotes (
T16978 2568-2579 JJ denotes approximate
T16979 2580-2589 JJ denotes molecular
T16980 2590-2597 NNS denotes weights
T16981 2598-2607 VBD denotes indicated
T16982 2608-2610 IN denotes on
T16983 2611-2615 NN denotes left
T16984 2615-2616 -RRB- denotes )
T16985 2616-2617 . denotes .
T16986 2618-2625 JJ denotes Similar
T16987 2626-2633 NNS denotes results
T16988 2634-2638 VBD denotes were
T16989 2639-2647 VBN denotes obtained
T16990 2648-2650 IN denotes in
T16991 2651-2654 CD denotes two
T16992 2655-2665 JJ denotes additional
T16993 2666-2677 NNS denotes experiments
T16994 2677-2678 . denotes .
T16995 2679-2680 -LRB- denotes (
T16996 2680-2681 NNP denotes B
T16997 2681-2682 -RRB- denotes )
T16998 2683-2687 NNP denotes CD40
T16999 2688-2691 VBD denotes was
T17000 2692-2700 VBN denotes isolated
T17001 2701-2703 IN denotes by
T17002 2704-2723 NN denotes immunoprecipitation
T17003 2724-2725 -LRB- denotes (
T17004 2725-2727 IN denotes as
T17005 2728-2730 IN denotes in
T17006 2731-2732 -LRB- denotes (
T17007 2732-2733 NN denotes A
T17008 2733-2734 -RRB- denotes )
T17009 2734-2735 -RRB- denotes )
T17010 2736-2740 IN denotes from
T17011 2741-2744 CD denotes A20
T17012 2744-2746 CD denotes .2
T17013 2746-2747 NNP denotes J
T17014 2748-2753 NNS denotes cells
T17015 2754-2757 CC denotes and
T17016 2758-2772 JJ denotes HOIP-deficient
T17017 2773-2778 NNS denotes cells
T17018 2779-2789 VBN denotes transduced
T17019 2795-2797 DT denotes an
T17020 2798-2803 JJ denotes empty
T17021 2804-2814 NN denotes retroviral
T17023 2822-2823 -LRB- denotes (
T17024 2823-2827 NNP denotes pMIP
T17025 2827-2828 -RRB- denotes )
T17026 2829-2831 CC denotes or
T17027 2832-2833 DT denotes a
T17028 2834-2844 JJ denotes retroviral
T17029 2845-2851 NN denotes vector
T17030 2852-2860 VBG denotes encoding
T17031 2861-2865 NNP denotes HOIP
T17032 2865-2866 . denotes .
T17033 2867-2875 NNP denotes Material
T17034 2876-2894 VBD denotes immunoprecipitated
T17035 2895-2899 IN denotes with
T17036 2900-2902 DT denotes an
T17037 2903-2910 NN denotes isotype
T17038 2911-2918 NN denotes control
T17039 2919-2927 NN denotes antibody
T17040 2928-2929 -LRB- denotes (
T17041 2929-2936 NN denotes isotype
T17042 2936-2937 -RRB- denotes )
T17043 2938-2940 CC denotes or
T17044 2941-2950 JJ denotes anti-CD40
T17045 2951-2959 NN denotes antibody
T17046 2960-2963 VBD denotes was
T17047 2964-2972 VBN denotes examined
T17048 2973-2975 IN denotes by
T17049 2976-2983 JJ denotes Western
T17050 2984-2992 VBG denotes blotting
T17051 2993-2996 IN denotes for
T17052 2997-3001 NNP denotes CD40
T17053 3001-3002 , denotes ,
T17054 3003-3008 CD denotes TRAF2
T17055 3008-3009 , denotes ,
T17056 3010-3015 CD denotes TRAF3
T17057 3015-3016 , denotes ,
T17058 3017-3022 NNP denotes cIAP1
T17059 3022-3023 , denotes ,
T17060 3024-3028 NNP denotes HOIP
T17061 3028-3029 , denotes ,
T17062 3030-3034 NNP denotes IKKα
T17063 3034-3035 NNP denotes /
T17064 3035-3036 NN denotes β
T17065 3036-3037 , denotes ,
T17066 3038-3041 CC denotes and
T17067 3042-3046 NNP denotes IKKγ
T17068 3047-3048 -LRB- denotes (
T17069 3048-3053 JJ denotes right
T17070 3054-3060 NNS denotes panels
T17071 3060-3061 -RRB- denotes )
T17072 3061-3062 . denotes .
T17073 3063-3067 NNP denotes HOIP
T17074 3068-3078 NN denotes expression
T17075 3079-3082 VBD denotes was
T17076 3083-3091 VBN denotes required
T17077 3092-3095 IN denotes for
T17078 3096-3111 NN denotes coprecipitation
T17079 3112-3114 IN denotes of
T17080 3115-3118 NNP denotes IKK
T17081 3119-3127 NNS denotes proteins
T17082 3128-3132 IN denotes with
T17083 3133-3137 NNP denotes CD40
T17084 3137-3138 . denotes .
T17085 3139-3143 NNP denotes Cell
T17086 3144-3151 VBZ denotes lysates
T17087 3152-3156 IN denotes from
T17088 3157-3169 JJ denotes unstimulated
T17089 3170-3175 NNS denotes cells
T17090 3176-3179 VBP denotes are
T17091 3180-3185 VBN denotes shown
T17092 3186-3188 IN denotes in
T17093 3189-3192 DT denotes the
T17094 3193-3197 VBN denotes left
T17095 3198-3204 NNS denotes panels
T17096 3204-3205 . denotes .
T17097 3206-3213 JJ denotes Similar
T17098 3214-3221 NNS denotes results
T17099 3222-3226 VBD denotes were
T17100 3227-3235 VBN denotes obtained
T17101 3236-3238 IN denotes in
T17102 3239-3240 DT denotes a
T17103 3241-3247 JJ denotes second
T17104 3248-3258 NN denotes experiment
T17105 3259-3262 CC denotes and
T17106 3263-3265 IN denotes in
T17107 3266-3269 CD denotes two
T17108 3270-3281 NNS denotes experiments
T17109 3282-3286 IN denotes with
T17110 3287-3288 DT denotes a
T17111 3289-3295 JJ denotes second
T17112 3296-3310 JJ denotes HOIP-deficient
T17113 3311-3316 NN denotes clone
T17114 3316-3317 . denotes .
T17115 3318-3319 -LRB- denotes (
T17116 3319-3320 $ denotes C
T17117 3320-3321 -RRB- denotes )
T17118 3745-3753 VBG denotes blotting
T17120 3325-3332 RBR denotes further
T17121 3333-3341 VB denotes evaluate
T17122 3342-3356 JJ denotes HOIP-dependent
T17123 3357-3368 NN denotes recruitment
T17124 3369-3371 IN denotes of
T17125 3372-3376 NNP denotes IKKγ
T17126 3377-3379 TO denotes to
T17127 3380-3384 NNP denotes CD40
T17128 3384-3385 , denotes ,
T17129 3386-3389 NNP denotes A20
T17130 3389-3391 CD denotes .2
T17131 3391-3392 NNP denotes J
T17132 3393-3398 NNS denotes cells
T17133 3399-3401 CC denotes or
T17134 3402-3416 JJ denotes HOIP-deficient
T17135 3417-3418 -LRB- denotes (
T17136 3418-3422 SYM denotes HOIP
T17137 3422-3423 : denotes -
T17138 3423-3424 SYM denotes /
T17139 3424-3425 : denotes -
T17140 3425-3426 -RRB- denotes )
T17141 3427-3430 CD denotes A20
T17142 3430-3432 CD denotes .2
T17143 3432-3433 NNP denotes J
T17144 3434-3439 NNS denotes cells
T17145 3440-3444 VBD denotes were
T17146 3445-3455 VBN denotes transduced
T17147 3456-3460 IN denotes with
T17148 3461-3463 DT denotes an
T17149 3464-3469 JJ denotes empty
T17150 3470-3480 NN denotes retroviral
T17151 3481-3487 NN denotes vector
T17152 3488-3490 CC denotes or
T17153 3491-3492 DT denotes a
T17154 3493-3503 JJ denotes retroviral
T17155 3504-3513 VBP denotes construct
T17156 3514-3522 VBG denotes encoding
T17157 3523-3525 NNP denotes BP
T17158 3526-3540 JJ denotes epitope-tagged
T17159 3541-3545 NNP denotes IKKγ
T17160 3546-3547 -LRB- denotes (
T17161 3547-3552 VBN denotes noted
T17162 3553-3555 IN denotes in
T17163 3556-3559 DT denotes the
T17164 3560-3566 NN denotes figure
T17165 3567-3569 IN denotes as
T17166 3570-3574 NNP denotes pMIP
T17167 3575-3578 CC denotes and
T17168 3579-3583 NNP denotes IKKγ
T17169 3583-3584 , denotes ,
T17170 3585-3597 RB denotes respectively
T17171 3597-3598 -RRB- denotes )
T17172 3598-3599 . denotes .
T17173 3600-3607 NNP denotes Lysates
T17174 3608-3609 -LRB- denotes (
T17175 3609-3614 NNS denotes lanes
T17176 3615-3616 CD denotes 1
T17177 3617-3618 LS denotes 3
T17178 3618-3619 -RRB- denotes )
T17179 3620-3623 CC denotes and
T17180 3624-3643 NN denotes immunoprecipitation
T17181 3644-3645 -LRB- denotes (
T17182 3645-3647 NNP denotes IP
T17183 3647-3648 -RRB- denotes )
T17184 3649-3656 NNS denotes samples
T17185 3657-3658 -LRB- denotes (
T17186 3658-3663 NNS denotes lanes
T17187 3664-3665 CD denotes 4
T17188 3666-3668 CD denotes 11
T17189 3668-3669 -RRB- denotes )
T17190 3670-3674 IN denotes from
T17191 3675-3678 DT denotes the
T17192 3679-3683 NN denotes cell
T17193 3684-3689 NNS denotes lines
T17194 3690-3694 VBD denotes were
T17195 3695-3707 VBN denotes fractionated
T17196 3708-3710 IN denotes by
T17197 3711-3719 NNP denotes SDS-PAGE
T17198 3720-3723 CC denotes and
T17199 3724-3733 VBN denotes evaluated
T17200 3734-3736 IN denotes by
T17201 3737-3744 JJ denotes Western
T17202 3754-3758 IN denotes with
T17203 3759-3769 NNS denotes antibodies
T17204 3770-3772 TO denotes to
T17205 3773-3776 DT denotes the
T17206 3777-3779 NNP denotes BP
T17207 3780-3783 NN denotes tag
T17208 3784-3785 -LRB- denotes (
T17209 3785-3789 NNP denotes IKKγ
T17210 3789-3790 , denotes ,
T17211 3791-3796 JJ denotes upper
T17212 3797-3802 NN denotes panel
T17213 3802-3803 -RRB- denotes )
T17214 3804-3807 CC denotes and
T17215 3808-3813 CD denotes TRAF2
T17216 3813-3814 . denotes .
T17217 3815-3818 DT denotes The
T17218 3819-3828 JJ denotes anti-CD40
T17219 3829-3831 NNP denotes IP
T17220 3832-3838 NN denotes sample
T17221 3839-3841 IN denotes in
T17222 3842-3846 NN denotes lane
T17223 3847-3849 CD denotes 11
T17224 3850-3853 VBD denotes was
T17225 3854-3861 VBN denotes treated
T17226 3862-3866 IN denotes with
T17227 3867-3868 JJ denotes λ
T17228 3869-3880 NN denotes phosphatase
T17229 3880-3881 : denotes ;
T17230 3882-3885 DT denotes the
T17231 3886-3892 NN denotes sample
T17232 3893-3895 IN denotes in
T17233 3896-3900 NN denotes lane
T17234 3901-3903 CD denotes 10
T17235 3904-3907 VBD denotes was
T17236 3908-3920 JJ denotes mock-treated
T17237 3920-3921 . denotes .
T17238 3922-3929 NN denotes Protein
T17239 3930-3937 NNS denotes samples
T17240 3938-3939 -LRB- denotes (
T17241 3939-3944 CC denotes minus
T17242 3945-3950 DT denotes those
T17243 3951-3958 VBN denotes treated
T17244 3959-3963 IN denotes with
T17245 3964-3975 NN denotes phosphatase
T17246 3975-3976 -RRB- denotes )
T17247 3977-3981 VBD denotes were
T17248 3982-3986 RB denotes also
T17249 3987-3999 VBN denotes fractionated
T17250 4000-4002 IN denotes on
T17251 4003-4004 DT denotes a
T17252 4005-4013 JJ denotes separate
T17253 4014-4017 NN denotes gel
T17254 4018-4019 -LRB- denotes (
T17255 4019-4024 JJR denotes lower
T17256 4025-4035 NN denotes acrylamide
T17257 4036-4049 NN denotes concentration
T17258 4049-4050 -RRB- denotes )
T17259 4051-4054 IN denotes for
T17260 4055-4058 DT denotes the
T17261 4059-4069 NN denotes evaluation
T17262 4070-4072 IN denotes of
T17263 4073-4078 CD denotes TRAF3
T17264 4079-4082 CC denotes and
T17265 4083-4087 NNP denotes HOIP
T17266 4088-4089 -LRB- denotes (
T17267 4089-4095 JJ denotes bottom
T17268 4096-4099 CD denotes two
T17269 4100-4106 NNS denotes panels
T17270 4106-4107 -RRB- denotes )
T17271 4107-4108 . denotes .
T17272 4109-4116 JJ denotes Similar
T17273 4117-4124 NNS denotes results
T17274 4125-4129 VBD denotes were
T17275 4130-4138 VBN denotes obtained
T17276 4139-4141 IN denotes in
T17277 4142-4145 CD denotes two
T17278 4146-4156 JJ denotes additional
T17279 4157-4168 NNS denotes experiments
T17280 4168-4169 . denotes .
T16917 2235-2239 VBD denotes were
T17022 2815-2821 NN denotes vector
T17119 3322-3324 TO denotes To
R5098 T6740 T6739 pobj CD40,with
R5099 T6741 T6742 nsubj The,marked
R5101 T6743 T6742 dobj defects,marked
R5102 T6744 T6743 prep in,defects
R5103 T6745 T6747 amod CD40-mediated,activation
R5104 T6746 T6747 compound cell,activation
R5105 T6747 T6744 pobj activation,in
R5106 T6748 T6742 cc and,marked
R5107 T6749 T6754 nsubj signaling,suggested
R5108 T6750 T6749 acl displayed,signaling
R5109 T6751 T6750 agent by,displayed
R5110 T6752 T6753 amod HOIP-deficient,cells
R5111 T6753 T6751 pobj cells,by
R5112 T6754 T6742 conj suggested,marked
R5113 T6755 T6757 mark that,mediates
R5114 T6756 T6757 nsubj HOIP,mediates
R5115 T6757 T6754 ccomp mediates,suggested
R5116 T6758 T6757 dobj recruitment,mediates
R5117 T6759 T6758 prep of,recruitment
R5118 T6760 T6761 amod critical,components
R5119 T6761 T6759 pobj components,of
R5120 T6762 T6761 prep of,components
R5121 T6763 T6766 det the,apparatus
R5122 T6764 T6766 nmod CD40,apparatus
R5123 T6765 T6766 amod signaling,apparatus
R5124 T6766 T6762 pobj apparatus,of
R5125 T6767 T6758 prep to,recruitment
R5126 T6768 T6769 det the,receptor
R5127 T6769 T6767 pobj receptor,to
R5128 T6770 T6754 punct .,suggested
R5129 T6771 T6774 advmod Previously,demonstrated
R5130 T6772 T6774 punct ",",demonstrated
R5131 T6773 T6774 nsubj we,demonstrated
R5132 T6774 T6774 ROOT demonstrated,demonstrated
R5133 T6775 T6778 mark that,recruited
R5134 T6776 T6778 nsubjpass HOIP,recruited
R5135 T6777 T6778 auxpass is,recruited
R5136 T6778 T6774 ccomp recruited,demonstrated
R5137 T6779 T6778 prep to,recruited
R5138 T6780 T6781 det the,CD40
R5139 T6781 T6782 nsubj CD40,signaling
R5140 T6782 T6779 pcomp signaling,to
R5141 T6783 T6782 dobj complex,signaling
R5142 T6784 T6782 prep in,signaling
R5143 T6785 T6787 det a,manner
R5144 T6786 T6787 amod TRAF2-dependent,manner
R5145 T6787 T6784 pobj manner,in
R5146 T6788 T6774 punct ",",demonstrated
R5147 T6789 T6774 advcl suggesting,demonstrated
R5148 T6790 T6792 mark that,functions
R5149 T6791 T6792 compound HOIP,functions
R5150 T6792 T6789 ccomp functions,suggesting
R5151 T6793 T6792 amod downstream,functions
R5152 T6794 T6793 prep of,downstream
R5153 T6795 T6798 nummod TRAF2,]
R5154 T6796 T6798 nmod [,]
R5155 T6797 T6796 nummod 6,[
R5156 T6798 T6794 pobj ],of
R5157 T6799 T6774 punct .,demonstrated
R5158 T6800 T6803 nsubj Studies,suggest
R5159 T6801 T6800 prep by,Studies
R5160 T6802 T6801 pobj others,by
R5161 T6803 T6803 ROOT suggest,suggest
R5162 T6804 T6808 mark that,cIAP1
R5163 T6805 T6807 det the,proteins
R5164 T6806 T6807 amod TRAF2-associated,proteins
R5165 T6807 T6808 nsubj proteins,cIAP1
R5166 T6808 T6803 ccomp cIAP1,suggest
R5167 T6809 T6808 cc and,cIAP1
R5168 T6810 T6808 conj cIAP2,cIAP1
R5169 T6811 T6803 conj play,suggest
R5170 T6812 T6813 det a,role
R5171 T6813 T6811 dobj role,play
R5172 T6814 T6813 prep in,role
R5173 T6815 T6816 det the,recruitment
R5174 T6816 T6814 pobj recruitment,in
R5175 T6817 T6816 prep of,recruitment
R5176 T6818 T6817 pobj HOIP,of
R5177 T6819 T6813 prep to,role
R5178 T6820 T6819 pobj TNFR1,to
R5179 T6821 T6820 cc and,TNFR1
R5180 T6822 T6820 conj CD40,TNFR1
R5181 T6823 T6825 nmod [,]
R5182 T6824 T6825 nummod 14,]
R5183 T6825 T6819 pobj ],to
R5184 T6826 T6803 punct .,suggest
R5185 T6827 T6830 advmod Therefore,determined
R5186 T6828 T6830 punct ",",determined
R5187 T6829 T6830 nsubj we,determined
R5188 T6830 T6830 ROOT determined,determined
R5189 T6831 T6844 mark whether,altered
R5190 T6832 T6833 det the,association
R5191 T6833 T6844 nsubjpass association,altered
R5192 T6834 T6833 prep of,association
R5193 T6835 T6834 pobj HOIP,of
R5194 T6836 T6833 prep with,association
R5195 T6837 T6836 pobj CD40,with
R5196 T6838 T6833 prep in,association
R5197 T6839 T6838 pobj A20,in
R5198 T6840 T6841 compound .2,J
R5199 T6841 T6842 compound J,cells
R5200 T6842 T6844 nsubjpass cells,altered
R5201 T6843 T6844 auxpass was,altered
R5202 T6844 T6830 ccomp altered,determined
R5203 T6845 T6844 agent by,altered
R5204 T6846 T6845 pobj treatment,by
R5205 T6847 T6846 prep of,treatment
R5206 T6848 T6847 pobj cells,of
R5207 T6849 T6844 prep with,altered
R5208 T6850 T6851 det an,inhibitor
R5209 T6851 T6849 pobj inhibitor,with
R5210 T6852 T6851 prep of,inhibitor
R5211 T6853 T6854 amod cIAP,activity
R5212 T6854 T6852 pobj activity,of
R5213 T6855 T6851 punct ",",inhibitor
R5214 T6856 T6858 det a,peptide
R5215 T6857 T6858 amod membrane-permeable,peptide
R5216 T6858 T6851 appos peptide,inhibitor
R5217 T6859 T6858 acl derived,peptide
R5218 T6860 T6859 prep from,derived
R5219 T6861 T6863 det the,regulator
R5220 T6862 T6863 compound apoptosis,regulator
R5221 T6863 T6860 pobj regulator,from
R5222 T6864 T6865 compound SMAC,[
R5223 T6865 T6863 appos [,regulator
R5224 T6866 T6867 nummod 15,]
R5225 T6867 T6863 appos ],regulator
R5226 T6868 T6830 punct .,determined
R5227 T6869 T6870 nsubj We,found
R5228 T6870 T6870 ROOT found,found
R5229 T6871 T6880 mark that,reduced
R5230 T6872 T6880 nsubj pretreatment,reduced
R5231 T6873 T6872 prep of,pretreatment
R5232 T6874 T6873 pobj cells,of
R5233 T6875 T6872 prep with,pretreatment
R5234 T6876 T6878 det the,peptide
R5235 T6877 T6878 compound SMAC,peptide
R5236 T6878 T6875 pobj peptide,with
R5237 T6879 T6880 advmod dramatically,reduced
R5238 T6880 T6870 ccomp reduced,found
R5239 T6881 T6882 det the,amount
R5240 T6882 T6880 dobj amount,reduced
R5241 T6883 T6882 prep of,amount
R5242 T6884 T6883 pobj cIAP1,of
R5243 T6885 T6882 acl associated,amount
R5244 T6886 T6885 prep with,associated
R5245 T6887 T6888 det the,CD40
R5246 T6888 T6889 nsubj CD40,signaling
R5247 T6889 T6886 pcomp signaling,with
R5248 T6890 T6889 ccomp complex,signaling
R5249 T6891 T6890 prep in,complex
R5250 T6892 T6891 pobj cells,in
R5251 T6893 T6892 acl stimulated,cells
R5252 T6894 T6893 prep with,stimulated
R5253 T6895 T6897 amod anti-CD40,beads
R5254 T6896 T6897 amod antibody-coated,beads
R5255 T6897 T6894 pobj beads,with
R5256 T6898 T6897 punct (,beads
R5257 T6899 T6900 compound Fig.,5A
R5258 T6900 T6897 appos 5A,beads
R5259 T6901 T6897 punct ),beads
R5260 T6902 T6870 punct .,found
R5261 T6903 T6905 compound SMAC,treatment
R5262 T6904 T6905 compound peptide,treatment
R5263 T6905 T6907 nsubj treatment,resulted
R5264 T6906 T6907 advmod also,resulted
R5265 T6907 T6907 ROOT resulted,resulted
R5266 T6908 T6907 prep in,resulted
R5267 T6909 T6913 det a,decrease
R5268 T6910 T6913 amod slight,decrease
R5269 T6911 T6910 cc but,slight
R5270 T6912 T6910 conj reproducible,slight
R5271 T6913 T6908 pobj decrease,in
R5272 T6914 T6913 prep in,decrease
R5273 T6915 T6916 det the,amount
R5274 T6916 T6914 pobj amount,in
R5275 T6917 T6916 prep of,amount
R5276 T6918 T6921 det the,form
R5277 T6919 T6921 amod major,form
R5278 T6920 T6921 compound HOIP,form
R5279 T6921 T6917 pobj form,of
R5280 T6922 T6921 acl recovered,form
R5281 T6923 T6922 agent by,recovered
R5282 T6924 T6925 compound CD40,immunoprecipitation
R5283 T6925 T6923 pobj immunoprecipitation,by
R5284 T6926 T6907 punct ",",resulted
R5285 T6927 T6907 prep along,resulted
R5286 T6928 T6927 prep with,along
R5287 T6929 T6931 det an,increase
R5288 T6930 T6931 amod apparent,increase
R5289 T6931 T6928 pobj increase,with
R5290 T6932 T6931 prep in,increase
R5291 T6933 T6936 amod higher,species
R5292 T6934 T6936 amod molecular,species
R5293 T6935 T6936 compound weight,species
R5294 T6936 T6932 pobj species,in
R5295 T6937 T6936 acl recognized,species
R5296 T6938 T6937 agent by,recognized
R5297 T6939 T6940 amod anti-HOIP,antibody
R5298 T6940 T6938 pobj antibody,by
R5299 T6941 T6907 punct .,resulted
R5300 T6942 T6952 prep In,alter
R5301 T6943 T6942 pobj contrast,In
R5302 T6944 T6952 punct ",",alter
R5303 T6945 T6952 nsubj treatment,alter
R5304 T6946 T6945 prep with,treatment
R5305 T6947 T6949 det the,peptide
R5306 T6948 T6949 compound SMAC,peptide
R5307 T6949 T6946 pobj peptide,with
R5308 T6950 T6952 aux did,alter
R5309 T6951 T6952 neg not,alter
R5310 T6952 T6952 ROOT alter,alter
R5311 T6953 T6954 det the,amount
R5312 T6954 T6952 dobj amount,alter
R5313 T6955 T6954 cc or,amount
R5314 T6956 T6957 amod molecular,weight
R5315 T6957 T6954 conj weight,amount
R5316 T6958 T6954 prep of,amount
R5317 T6959 T6960 compound HOIP,present
R5318 T6960 T6958 pobj present,of
R5319 T6961 T6960 prep in,present
R5320 T6962 T6963 compound cell,lysates
R5321 T6963 T6961 pobj lysates,in
R5322 T6964 T6952 punct .,alter
R5323 T6965 T6966 det These,data
R5324 T6966 T6967 nsubj data,suggest
R5325 T6967 T6967 ROOT suggest,suggest
R5326 T6968 T6973 mark that,alters
R5327 T6969 T6971 compound SMAC,treatment
R5328 T6970 T6971 compound peptide,treatment
R5329 T6971 T6973 nsubj treatment,alters
R5330 T6972 T6973 advmod specifically,alters
R5331 T6973 T6967 ccomp alters,suggest
R5332 T6974 T6975 det the,characteristics
R5333 T6975 T6973 dobj characteristics,alters
R5334 T6976 T6975 prep of,characteristics
R5335 T6977 T6978 compound CD40-associated,HOIP
R5336 T6978 T6976 pobj HOIP,of
R5337 T6979 T6980 advmod rather,than
R5338 T6980 T6975 cc than,characteristics
R5339 T6981 T6984 det the,pool
R5340 T6982 T6984 amod entire,pool
R5341 T6983 T6984 amod cellular,pool
R5342 T6984 T6980 pobj pool,than
R5343 T6985 T6984 prep of,pool
R5344 T6986 T6987 det this,protein
R5345 T6987 T6985 pobj protein,of
R5346 T6988 T6967 punct .,suggest
R5347 T6989 T6993 advmod Together,support
R5348 T6990 T6993 punct ",",support
R5349 T6991 T6992 det these,results
R5350 T6992 T6993 nsubj results,support
R5351 T6993 T6993 ROOT support,support
R5352 T6994 T6995 det the,idea
R5353 T6995 T6993 dobj idea,support
R5354 T6996 T7000 mark that,influence
R5355 T6997 T6999 det the,proteins
R5356 T6998 T6999 compound cIAP,proteins
R5357 T6999 T7000 nsubj proteins,influence
R5358 T7000 T6995 acl influence,idea
R5359 T7001 T7002 det the,recruitment
R5360 T7002 T7000 dobj recruitment,influence
R5361 T7003 T7002 cc and,recruitment
R5362 T7004 T7006 amod post-translational,state
R5363 T7005 T7006 compound modification,state
R5364 T7006 T7002 conj state,recruitment
R5365 T7007 T7002 prep of,recruitment
R5366 T7008 T7009 compound CD40-associated,HOIP
R5367 T7009 T7007 pobj HOIP,of
R5368 T7010 T6993 punct .,support
R5369 T7011 T7012 aux To,test
R5370 T7012 T7031 advcl test,immunoprecipitated
R5371 T7013 T7014 det the,possibility
R5372 T7014 T7012 dobj possibility,test
R5373 T7015 T7017 mark that,is
R5374 T7016 T7017 nsubj HOIP,is
R5375 T7017 T7014 acl is,possibility
R5376 T7018 T7017 acomp responsible,is
R5377 T7019 T7018 prep for,responsible
R5378 T7020 T7021 det the,recruitment
R5379 T7021 T7019 pobj recruitment,for
R5380 T7022 T7021 prep of,recruitment
R5381 T7023 T7026 amod other,proteins
R5382 T7024 T7026 amod critical,proteins
R5383 T7025 T7026 amod signaling,proteins
R5384 T7026 T7022 pobj proteins,of
R5385 T7027 T7021 prep to,recruitment
R5386 T7028 T7027 pobj CD40,to
R5387 T7029 T7031 punct ",",immunoprecipitated
R5388 T7030 T7031 nsubj we,immunoprecipitated
R5389 T7031 T7031 ROOT immunoprecipitated,immunoprecipitated
R5390 T7032 T7031 dobj CD40,immunoprecipitated
R5391 T7033 T7031 advcl signaling,immunoprecipitated
R5392 T7034 T7033 dobj complexes,signaling
R5393 T7035 T7034 prep from,complexes
R5394 T7036 T7039 amod HOIP-deficient,cells
R5395 T7037 T7036 cc and,HOIP-deficient
R5396 T7038 T7036 conj HOIP-reconstituted,HOIP-deficient
R5397 T7039 T7035 pobj cells,from
R5398 T7040 T7034 punct (,complexes
R5399 T7041 T7042 compound Fig.,5B
R5400 T7042 T7034 appos 5B,complexes
R5401 T7043 T7034 punct ),complexes
R5402 T7044 T7031 punct .,immunoprecipitated
R5403 T7045 T7046 mark As,described
R5404 T7046 T7058 advcl described,contained
R5405 T7047 T7046 advmod previously,described
R5406 T7048 T7058 punct ",",contained
R5407 T7049 T7058 nsubj CD40,contained
R5408 T7050 T7058 advcl signaling,contained
R5409 T7051 T7058 nsubj complexes,contained
R5410 T7052 T7051 acl immunoprecipitated,complexes
R5411 T7053 T7052 prep from,immunoprecipitated
R5412 T7054 T7057 nummod A20,cells
R5413 T7055 T7057 nummod .2,cells
R5414 T7056 T7057 compound J,cells
R5415 T7057 T7053 pobj cells,from
R5416 T7058 T7058 ROOT contained,contained
R5417 T7059 T7058 dobj HOIP,contained
R5418 T7060 T7062 advmod as,as
R5419 T7061 T7062 advmod well,as
R5420 T7062 T7059 cc as,HOIP
R5421 T7063 T7059 conj TRAF2,HOIP
R5422 T7064 T7059 punct ",",HOIP
R5423 T7065 T7059 appos TRAF3,HOIP
R5424 T7066 T7059 punct ",",HOIP
R5425 T7067 T7069 compound IKKα,β
R5426 T7068 T7069 compound /,β
R5427 T7069 T7059 appos β,HOIP
R5428 T7070 T7059 punct ",",HOIP
R5429 T7071 T7059 cc and,HOIP
R5430 T7072 T7073 compound IKKγ,[
R5431 T7073 T7059 conj [,HOIP
R5432 T7074 T7075 nummod 6,]
R5433 T7075 T7059 conj ],HOIP
R5434 T7076 T7058 punct .,contained
R5435 T7077 T7078 det The,amounts
R5436 T7078 T7092 nsubj amounts,were
R5437 T7079 T7078 prep of,amounts
R5438 T7080 T7079 pobj TRAF2,of
R5439 T7081 T7078 punct ",",amounts
R5440 T7082 T7078 appos TRAF3,amounts
R5441 T7083 T7078 punct ",",amounts
R5442 T7084 T7078 cc and,amounts
R5443 T7085 T7078 conj cIAP1,amounts
R5444 T7086 T7085 prep in,cIAP1
R5445 T7087 T7086 pobj CD40,in
R5446 T7088 T7085 dep immunoprecipitates,cIAP1
R5447 T7089 T7088 prep from,immunoprecipitates
R5448 T7090 T7091 amod HOIP-deficient,cells
R5449 T7091 T7089 pobj cells,from
R5450 T7092 T7092 ROOT were,were
R5451 T7093 T7092 acomp similar,were
R5452 T7094 T7093 prep to,similar
R5453 T7095 T7094 pobj those,to
R5454 T7096 T7095 prep from,those
R5455 T7097 T7101 amod parental,cells
R5456 T7098 T7101 compound A20,cells
R5457 T7099 T7100 compound .2,J
R5458 T7100 T7101 compound J,cells
R5459 T7101 T7096 pobj cells,from
R5460 T7102 T7092 punct ",",were
R5461 T7103 T7092 advcl indicating,were
R5462 T7104 T7108 mark that,required
R5463 T7105 T7108 nsubjpass HOIP,required
R5464 T7106 T7108 auxpass is,required
R5465 T7107 T7108 neg not,required
R5466 T7108 T7103 ccomp required,indicating
R5467 T7109 T7108 prep for,required
R5468 T7110 T7111 det the,association
R5469 T7111 T7109 pobj association,for
R5470 T7112 T7111 prep of,association
R5471 T7113 T7114 det these,proteins
R5472 T7114 T7112 pobj proteins,of
R5473 T7115 T7111 prep with,association
R5474 T7116 T7115 pobj CD40,with
R5475 T7117 T7092 punct .,were
R5476 T7118 T7126 prep In,were
R5477 T7119 T7118 pobj contrast,In
R5478 T7120 T7126 punct ",",were
R5479 T7121 T7123 compound IKKα,β
R5480 T7122 T7123 compound /,β
R5481 T7123 T7126 nsubj β,were
R5482 T7124 T7123 cc and,β
R5483 T7125 T7123 conj IKKγ,β
R5484 T7126 T7126 ROOT were,were
R5485 T7127 T7126 neg not,were
R5486 T7128 T7126 acomp detectable,were
R5487 T7129 T7128 prep in,detectable
R5488 T7130 T7131 nummod CD40,immunoprecipitates
R5489 T7131 T7129 pobj immunoprecipitates,in
R5490 T7132 T7131 acl recovered,immunoprecipitates
R5491 T7133 T7132 prep from,recovered
R5492 T7134 T7135 amod HOIP-deficient,cells
R5493 T7135 T7133 pobj cells,from
R5494 T7136 T7132 punct (,recovered
R5495 T7137 T7138 compound Fig.,5B
R5496 T7138 T7138 ROOT 5B,5B
R5497 T7139 T7140 punct ",",C
R5498 T7140 T7138 appos C,5B
R5499 T7141 T7138 punct ),5B
R5500 T7142 T7132 punct .,recovered
R5501 T7143 T7144 det The,amounts
R5502 T7144 T7153 nsubj amounts,immunoprecipitates
R5503 T7145 T7144 prep of,amounts
R5504 T7146 T7148 compound IKKα,β
R5505 T7147 T7148 compound /,β
R5506 T7148 T7145 pobj β,of
R5507 T7149 T7148 cc and,β
R5508 T7150 T7148 conj IKKγ,β
R5509 T7151 T7150 prep in,IKKγ
R5510 T7152 T7151 pobj CD40,in
R5511 T7153 T7157 nsubj immunoprecipitates,were
R5512 T7154 T7153 prep from,immunoprecipitates
R5513 T7155 T7156 amod HOIP-reconstituted,cells
R5514 T7156 T7154 pobj cells,from
R5515 T7157 T7157 ROOT were,were
R5516 T7158 T7157 acomp similar,were
R5517 T7159 T7158 prep to,similar
R5518 T7160 T7159 pobj those,to
R5519 T7161 T7160 acl detected,those
R5520 T7162 T7161 prep in,detected
R5521 T7163 T7162 pobj samples,in
R5522 T7164 T7163 acl prepared,samples
R5523 T7165 T7164 prep from,prepared
R5524 T7166 T7167 amod parental,cells
R5525 T7167 T7165 pobj cells,from
R5526 T7168 T7157 punct ",",were
R5527 T7169 T7157 advcl demonstrating,were
R5528 T7170 T7178 mark that,were
R5529 T7171 T7172 det the,defects
R5530 T7172 T7178 nsubj defects,were
R5531 T7173 T7172 prep in,defects
R5532 T7174 T7175 compound IKK,recruitment
R5533 T7175 T7173 pobj recruitment,in
R5534 T7176 T7177 nsubj we,observed
R5535 T7177 T7172 relcl observed,defects
R5536 T7178 T7169 ccomp were,demonstrating
R5537 T7179 T7178 acomp due,were
R5538 T7180 T7181 advmod specifically,to
R5539 T7181 T7179 prep to,due
R5540 T7182 T7183 det the,absence
R5541 T7183 T7181 pobj absence,to
R5542 T7184 T7183 prep of,absence
R5543 T7185 T7186 compound HOIP,expression
R5544 T7186 T7184 pobj expression,of
R5545 T7187 T7157 punct .,were
R5546 T7188 T7189 det These,data
R5547 T7189 T7190 nsubj data,indicate
R5548 T7190 T7190 ROOT indicate,indicate
R5549 T7191 T7194 mark that,required
R5550 T7192 T7194 nsubjpass HOIP,required
R5551 T7193 T7194 auxpass is,required
R5552 T7194 T7190 ccomp required,indicate
R5553 T7195 T7194 prep for,required
R5554 T7196 T7195 pobj recruitment,for
R5555 T7197 T7196 prep of,recruitment
R5556 T7198 T7200 det the,complex
R5557 T7199 T7200 amod NF-κB-activating,complex
R5558 T7200 T7197 pobj complex,of
R5559 T7201 T7200 prep to,complex
R5560 T7202 T7203 det the,CD40
R5561 T7203 T7204 nsubj CD40,signaling
R5562 T7204 T7201 pcomp signaling,to
R5563 T7205 T7204 dobj complex,signaling
R5564 T7206 T7190 punct .,indicate
R5565 T7207 T7208 mark As,shown
R5566 T7208 T7208 ROOT shown,shown
R5567 T7209 T7208 advmod here,shown
R5568 T7210 T7208 cc and,shown
R5569 T7211 T7220 prep in,present
R5570 T7212 T7214 poss our,study
R5571 T7213 T7214 amod previous,study
R5572 T7214 T7211 pobj study,in
R5573 T7215 T7217 nmod [,]
R5574 T7216 T7217 nummod 6,]
R5575 T7217 T7220 nsubj ],present
R5576 T7218 T7220 punct ",",present
R5577 T7219 T7220 compound IKKγ,present
R5578 T7220 T7224 nsubj present,appears
R5579 T7221 T7220 prep in,present
R5580 T7222 T7221 pobj CD40,in
R5581 T7223 T7224 nsubj immunoprecipitates,appears
R5582 T7224 T7208 conj appears,shown
R5583 T7225 T7226 aux to,have
R5584 T7226 T7224 xcomp have,appears
R5585 T7227 T7230 det a,weight
R5586 T7228 T7230 amod higher,weight
R5587 T7229 T7230 amod molecular,weight
R5588 T7230 T7226 dobj weight,have
R5589 T7231 T7230 prep than,weight
R5590 T7232 T7231 pobj that,than
R5591 T7233 T7232 acl found,that
R5592 T7234 T7233 prep in,found
R5593 T7235 T7236 compound cell,lysates
R5594 T7236 T7234 pobj lysates,in
R5595 T7237 T7224 punct .,appears
R5596 T7238 T7239 aux To,confirm
R5597 T7239 T7251 advcl confirm,generated
R5598 T7240 T7246 mark that,was
R5599 T7241 T7245 det this,species
R5600 T7242 T7244 amod higher,weight
R5601 T7243 T7244 amod molecular,weight
R5602 T7244 T7245 compound weight,species
R5603 T7245 T7246 nsubj species,was
R5604 T7246 T7239 ccomp was,confirm
R5605 T7247 T7246 advmod indeed,was
R5606 T7248 T7246 attr IKKγ,was
R5607 T7249 T7251 punct ",",generated
R5608 T7250 T7251 nsubj we,generated
R5609 T7251 T7251 ROOT generated,generated
R5610 T7252 T7256 compound A20,lines
R5611 T7253 T7254 compound .2,J
R5612 T7254 T7256 compound J,lines
R5613 T7255 T7256 compound cell,lines
R5614 T7256 T7251 dobj lines,generated
R5615 T7257 T7256 acl containing,lines
R5616 T7258 T7262 det a,vector
R5617 T7259 T7260 advmod stably,integrated
R5618 T7260 T7262 amod integrated,vector
R5619 T7261 T7262 amod retroviral,vector
R5620 T7262 T7257 dobj vector,containing
R5621 T7263 T7264 nsubj that,encoded
R5622 T7264 T7262 relcl encoded,vector
R5623 T7265 T7267 det an,version
R5624 T7266 T7267 amod epitope-tagged,version
R5625 T7267 T7264 dobj version,encoded
R5626 T7268 T7267 prep of,version
R5627 T7269 T7268 pobj mouse,of
R5628 T7270 T7267 appos IKKγ,version
R5629 T7271 T7251 punct .,generated
R5630 T7272 T7273 compound Cell,lysates
R5631 T7273 T7282 nsubjpass lysates,analyzed
R5632 T7274 T7273 cc and,lysates
R5633 T7275 T7276 amod CD40,immunoprecipitates
R5634 T7276 T7273 conj immunoprecipitates,lysates
R5635 T7277 T7273 acl prepared,lysates
R5636 T7278 T7277 prep from,prepared
R5637 T7279 T7280 det these,cells
R5638 T7280 T7278 pobj cells,from
R5639 T7281 T7282 auxpass were,analyzed
R5640 T7282 T7282 ROOT analyzed,analyzed
R5641 T7283 T7282 agent by,analyzed
R5642 T7284 T7285 amod Western,blotting
R5643 T7285 T7283 pobj blotting,by
R5644 T7286 T7282 prep for,analyzed
R5645 T7287 T7289 det the,tag
R5646 T7288 T7289 compound epitope,tag
R5647 T7289 T7286 pobj tag,for
R5648 T7290 T7289 punct (,tag
R5649 T7291 T7292 compound Fig.,5C
R5650 T7292 T7289 appos 5C,tag
R5651 T7293 T7289 punct ),tag
R5652 T7294 T7282 punct .,analyzed
R5653 T7295 T7296 det This,analysis
R5654 T7296 T7297 nsubj analysis,produced
R5655 T7297 T7297 ROOT produced,produced
R5656 T7298 T7299 det a,pattern
R5657 T7299 T7297 dobj pattern,produced
R5658 T7300 T7299 prep of,pattern
R5659 T7301 T7300 pobj bands,of
R5660 T7302 T7303 nsubj that,was
R5661 T7303 T7299 relcl was,pattern
R5662 T7304 T7303 advmod essentially,was
R5663 T7305 T7306 det the,same
R5664 T7306 T7303 attr same,was
R5665 T7307 T7306 prep as,same
R5666 T7308 T7309 det that,obtained
R5667 T7309 T7307 pobj obtained,as
R5668 T7310 T7303 advcl using,was
R5669 T7311 T7313 det an,specific
R5670 T7312 T7313 compound antibody,specific
R5671 T7313 T7310 dobj specific,using
R5672 T7314 T7313 prep for,specific
R5673 T7315 T7316 amod native,IKKγ
R5674 T7316 T7314 pobj IKKγ,for
R5675 T7317 T7318 punct (,compare
R5676 T7318 T7310 xcomp compare,using
R5677 T7319 T7318 dobj panels,compare
R5678 T7320 T7318 conj B,compare
R5679 T7321 T7320 cc and,B
R5680 T7322 T7320 conj C,B
R5681 T7323 T7318 prep in,compare
R5682 T7324 T7323 pobj Fig.,in
R5683 T7325 T7324 nummod 5,Fig.
R5684 T7326 T7318 punct ),compare
R5685 T7327 T7297 punct .,produced
R5686 T7328 T7336 advmod Moreover,confirmed
R5687 T7329 T7336 punct ",",confirmed
R5688 T7330 T7336 nsubj analysis,confirmed
R5689 T7331 T7330 prep of,analysis
R5690 T7332 T7331 pobj cells,of
R5691 T7333 T7332 acl expressing,cells
R5692 T7334 T7335 compound epitope,tagged-IKKγ
R5693 T7335 T7333 dobj tagged-IKKγ,expressing
R5694 T7336 T7336 ROOT confirmed,confirmed
R5695 T7337 T7343 mark that,requires
R5696 T7338 T7343 nsubj recruitment,requires
R5697 T7339 T7338 prep of,recruitment
R5698 T7340 T7339 pobj IKKγ,of
R5699 T7341 T7338 prep to,recruitment
R5700 T7342 T7341 pobj CD40,to
R5701 T7343 T7336 ccomp requires,confirmed
R5702 T7344 T7343 dobj HOIP,requires
R5703 T7345 T7336 punct .,confirmed
R5704 T7346 T7347 aux To,determine
R5705 T7347 T7366 advcl determine,incubated
R5706 T7348 T7349 nsubj what,was
R5707 T7349 T7347 ccomp was,determine
R5708 T7350 T7349 acomp responsible,was
R5709 T7351 T7350 prep for,responsible
R5710 T7352 T7355 det the,weight
R5711 T7353 T7355 amod increased,weight
R5712 T7354 T7355 amod molecular,weight
R5713 T7355 T7351 pobj weight,for
R5714 T7356 T7355 prep of,weight
R5715 T7357 T7356 pobj IKKγ,of
R5716 T7358 T7355 prep in,weight
R5717 T7359 T7360 compound CD40,immunoprecipitates
R5718 T7360 T7358 pobj immunoprecipitates,in
R5719 T7361 T7366 punct ",",incubated
R5720 T7362 T7364 det the,samples
R5721 T7363 T7364 compound protein,samples
R5722 T7364 T7366 nsubjpass samples,incubated
R5723 T7365 T7366 auxpass were,incubated
R5724 T7366 T7366 ROOT incubated,incubated
R5725 T7367 T7366 prep with,incubated
R5726 T7368 T7369 compound lambda,phosphatase
R5727 T7369 T7367 pobj phosphatase,with
R5728 T7370 T7369 punct ",",phosphatase
R5729 T7371 T7372 nsubj which,removes
R5730 T7372 T7369 relcl removes,phosphatase
R5731 T7373 T7372 dobj phosphates,removes
R5732 T7374 T7373 acl attached,phosphates
R5733 T7375 T7376 aux to,tyrosine
R5734 T7376 T7374 xcomp tyrosine,attached
R5735 T7377 T7376 punct ",",tyrosine
R5736 T7378 T7376 conj threonine,tyrosine
R5737 T7379 T7378 punct ",",threonine
R5738 T7380 T7378 cc or,threonine
R5739 T7381 T7378 conj serine,threonine
R5740 T7382 T7378 conj residues,threonine
R5741 T7383 T7382 prep in,residues
R5742 T7384 T7383 pobj proteins,in
R5743 T7385 T7366 punct .,incubated
R5744 T7386 T7387 det This,treatment
R5745 T7387 T7388 nsubj treatment,reduced
R5746 T7388 T7388 ROOT reduced,reduced
R5747 T7389 T7388 dobj much,reduced
R5748 T7390 T7389 prep of,much
R5749 T7391 T7392 compound CD40-associated,IKKγ
R5750 T7392 T7390 pobj IKKγ,of
R5751 T7393 T7388 prep to,reduced
R5752 T7394 T7397 det an,weight
R5753 T7395 T7397 amod apparent,weight
R5754 T7396 T7397 amod molecular,weight
R5755 T7397 T7393 pobj weight,to
R5756 T7398 T7397 amod similar,weight
R5757 T7399 T7398 prep to,similar
R5758 T7400 T7399 pobj that,to
R5759 T7401 T7400 prep of,that
R5760 T7402 T7403 det the,protein
R5761 T7403 T7401 pobj protein,of
R5762 T7404 T7398 prep in,similar
R5763 T7405 T7406 compound cell,lysates
R5764 T7406 T7404 pobj lysates,in
R5765 T7407 T7409 punct (,5C
R5766 T7408 T7409 compound Fig.,5C
R5767 T7409 T7398 appos 5C,similar
R5768 T7410 T7409 punct ),5C
R5769 T7411 T7388 punct .,reduced
R5770 T7412 T7423 advmod However,remained
R5771 T7413 T7423 punct ",",remained
R5772 T7414 T7415 advmod at,least
R5773 T7415 T7416 advmod least,one
R5774 T7416 T7417 nummod one,band
R5775 T7417 T7423 nsubj band,remained
R5776 T7418 T7417 prep of,band
R5777 T7419 T7420 advmod significantly,higher
R5778 T7420 T7422 amod higher,weight
R5779 T7421 T7422 amod molecular,weight
R5780 T7422 T7418 pobj weight,of
R5781 T7423 T7423 ROOT remained,remained
R5782 T7424 T7423 prep after,remained
R5783 T7425 T7426 compound phosphatase,treatment
R5784 T7426 T7424 pobj treatment,after
R5785 T7427 T7423 punct ",",remained
R5786 T7428 T7423 advcl suggesting,remained
R5787 T7429 T7432 mark that,is
R5788 T7430 T7431 compound CD40-associated,IKKγ
R5789 T7431 T7432 nsubj IKKγ,is
R5790 T7432 T7428 ccomp is,suggesting
R5791 T7433 T7432 acomp subject,is
R5792 T7434 T7433 prep to,subject
R5793 T7435 T7436 advmod at,least
R5794 T7436 T7437 advmod least,one
R5795 T7437 T7439 nummod one,modification
R5796 T7438 T7439 amod other,modification
R5797 T7439 T7434 pobj modification,to
R5798 T7440 T7439 prep in,modification
R5799 T7441 T7440 pobj addition,in
R5800 T7442 T7441 prep to,addition
R5801 T7443 T7442 pobj phosphorylation,to
R5802 T7444 T7423 punct .,remained
R5803 T7445 T7449 advmod Overall,demonstrate
R5804 T7446 T7449 punct ",",demonstrate
R5805 T7447 T7448 det these,data
R5806 T7448 T7449 nsubj data,demonstrate
R5807 T7449 T7449 ROOT demonstrate,demonstrate
R5808 T7450 T7453 mark that,required
R5809 T7451 T7453 nsubjpass HOIP,required
R5810 T7452 T7453 auxpass is,required
R5811 T7453 T7449 ccomp required,demonstrate
R5812 T7454 T7453 prep for,required
R5813 T7455 T7456 det the,association
R5814 T7456 T7454 pobj association,for
R5815 T7457 T7456 prep of,association
R5816 T7458 T7457 pobj IKKγ,of
R5817 T7459 T7456 prep with,association
R5818 T7460 T7459 pobj CD40,with
R5819 T7461 T7453 punct ",",required
R5820 T7462 T7453 cc and,required
R5821 T7463 T7449 conj suggest,demonstrate
R5822 T7464 T7468 mark that,coupled
R5823 T7465 T7466 det this,event
R5824 T7466 T7468 nsubjpass event,coupled
R5825 T7467 T7468 auxpass is,coupled
R5826 T7468 T7463 ccomp coupled,suggest
R5827 T7469 T7468 prep to,coupled
R5828 T7470 T7471 amod post-translational,modifications
R5829 T7471 T7469 pobj modifications,to
R5830 T7472 T7471 prep of,modifications
R5831 T7473 T7472 pobj IKKγ,of
R5832 T7474 T7449 punct .,demonstrate
R13183 T16830 T16831 compound IKK,recruitment
R13184 T16831 T16831 ROOT recruitment,recruitment
R13185 T16832 T16831 prep to,recruitment
R13186 T16833 T16834 det the,CD40
R13187 T16834 T16832 pobj CD40,to
R13188 T16835 T16831 acl signaling,recruitment
R13189 T16836 T16837 nsubj complex,is
R13190 T16837 T16835 ccomp is,signaling
R13191 T16838 T16837 acomp defective,is
R13192 T16839 T16838 prep in,defective
R13193 T16840 T16841 amod HOIP-deficient,cells
R13194 T16841 T16839 pobj cells,in
R13195 T16842 T16831 punct .,recruitment
R13196 T16843 T16849 punct (,reduces
R13197 T16844 T16848 det A,treatment
R13198 T16845 T16846 punct ),SMAC
R13199 T16846 T16848 nmod SMAC,treatment
R13200 T16847 T16848 compound peptide,treatment
R13201 T16848 T16849 nsubj treatment,reduces
R13202 T16849 T16849 ROOT reduces,reduces
R13203 T16850 T16849 dobj recruitment,reduces
R13204 T16851 T16850 prep of,recruitment
R13205 T16852 T16851 pobj cIAP1,of
R13206 T16853 T16849 prep to,reduces
R13207 T16854 T16853 pobj CD40,to
R13208 T16855 T16849 cc and,reduces
R13209 T16856 T16857 aux may,modify
R13210 T16857 T16849 conj modify,reduces
R13211 T16858 T16859 compound HOIP,recruitment
R13212 T16859 T16857 dobj recruitment,modify
R13213 T16860 T16849 punct .,reduces
R13214 T16861 T16864 nummod A20,cells
R13215 T16862 T16864 nummod .2,cells
R13216 T16863 T16864 compound J,cells
R13217 T16864 T16866 nsubjpass cells,incubated
R13218 T16865 T16866 auxpass were,incubated
R13219 T16866 T16866 ROOT incubated,incubated
R13220 T16867 T16866 prep for,incubated
R13221 T16868 T16869 nummod six,hours
R13222 T16869 T16867 pobj hours,for
R13223 T16870 T16866 prep with,incubated
R13224 T16871 T16873 amod membrane-permeable,peptide
R13225 T16872 T16873 compound SMAC-N7,peptide
R13226 T16873 T16870 pobj peptide,with
R13227 T16874 T16873 cc or,peptide
R13228 T16875 T16876 nummod 1.5,%
R13229 T16876 T16877 compound %,DMSO
R13230 T16877 T16873 conj DMSO,peptide
R13231 T16878 T16880 punct (,used
R13232 T16879 T16880 advmod solvent,used
R13233 T16880 T16866 advcl used,incubated
R13234 T16881 T16880 prep for,used
R13235 T16882 T16883 det the,peptide
R13236 T16883 T16881 pobj peptide,for
R13237 T16884 T16880 punct ),used
R13238 T16885 T16866 punct .,incubated
R13239 T16886 T16893 prep Following,prepared
R13240 T16887 T16888 det the,incubation
R13241 T16888 T16886 pobj incubation,Following
R13242 T16889 T16893 punct ",",prepared
R13243 T16890 T16891 compound cell,lysates
R13244 T16891 T16893 nsubjpass lysates,prepared
R13245 T16892 T16893 auxpass were,prepared
R13246 T16893 T16893 ROOT prepared,prepared
R13247 T16894 T16893 punct ",",prepared
R13248 T16895 T16893 conj fractionated,prepared
R13249 T16896 T16895 agent by,fractionated
R13250 T16897 T16896 pobj SDS-PAGE,by
R13251 T16898 T16895 punct ",",fractionated
R13252 T16899 T16895 cc and,fractionated
R13253 T16900 T16895 conj evaluated,fractionated
R13254 T16901 T16900 agent by,evaluated
R13255 T16902 T16903 amod Western,blot
R13256 T16903 T16901 pobj blot,by
R13257 T16904 T16905 punct (,lanes
R13258 T16905 T16900 parataxis lanes,evaluated
R13259 T16906 T16905 nummod 1,lanes
R13260 T16907 T16905 cc and,lanes
R13261 T16908 T16905 conj 2,lanes
R13262 T16909 T16905 punct ),lanes
R13263 T16910 T16893 punct .,prepared
R13264 T16911 T16912 nsubj Cells,incubated
R13265 T16912 T16912 ROOT incubated,incubated
R13266 T16913 T16912 prep with,incubated
R13267 T16914 T16913 pobj DMSO,with
R13268 T16915 T16914 cc or,DMSO
R13269 T16916 T16914 conj SMAC-N7,DMSO
R13270 T16917 T16919 auxpass were,stimulated
R13271 T16918 T16919 advmod also,stimulated
R13272 T16919 T16912 conj stimulated,incubated
R13273 T16920 T16919 prep with,stimulated
R13274 T16921 T16922 amod magnetic,beads
R13275 T16922 T16920 pobj beads,with
R13276 T16923 T16922 acl coated,beads
R13277 T16924 T16923 prep with,coated
R13278 T16925 T16924 pobj anti-CD40,with
R13279 T16926 T17018 prep with,transduced
R13280 T16927 T16925 cc or,anti-CD40
R13281 T16928 T16931 det an,antibody
R13282 T16929 T16930 compound isotype,control
R13283 T16930 T16931 compound control,antibody
R13284 T16931 T16925 conj antibody,anti-CD40
R13285 T16932 T16919 punct .,stimulated
R13286 T16933 T16937 amod Immunoprecipitated,material
R13287 T16934 T16937 punct (,material
R13288 T16935 T16937 amod IP,material
R13289 T16936 T16937 punct ),material
R13290 T16937 T16943 nsubjpass material,loaded
R13291 T16938 T16937 acl bound,material
R13292 T16939 T16938 prep to,bound
R13293 T16940 T16941 det the,beads
R13294 T16941 T16939 pobj beads,to
R13295 T16942 T16943 auxpass was,loaded
R13296 T16943 T16943 ROOT loaded,loaded
R13297 T16944 T16943 prep in,loaded
R13298 T16945 T16944 pobj lanes,in
R13299 T16946 T16943 advmod 3-5,loaded
R13300 T16947 T16943 punct .,loaded
R13301 T16948 T16952 nsubj Samples,lysates
R13302 T16949 T16948 prep of,Samples
R13303 T16950 T16951 det the,cell
R13304 T16951 T16949 pobj cell,of
R13305 T16952 T16952 ROOT lysates,lysates
R13306 T16953 T16955 mark after,appear
R13307 T16954 T16955 nsubj immunoprecipitation,appear
R13308 T16955 T16952 advcl appear,lysates
R13309 T16956 T16955 prep in,appear
R13310 T16957 T16956 pobj lanes,in
R13311 T16958 T16955 npadvmod 6,appear
R13312 T16959 T16958 appos 8,6
R13313 T16960 T16952 punct .,lysates
R13314 T16961 T16962 amod Western,blots
R13315 T16962 T16964 nsubjpass blots,probed
R13316 T16963 T16964 auxpass were,probed
R13317 T16964 T16964 ROOT probed,probed
R13318 T16965 T16964 prep with,probed
R13319 T16966 T16965 pobj antibodies,with
R13320 T16967 T16966 amod specific,antibodies
R13321 T16968 T16967 prep for,specific
R13322 T16969 T16968 pobj cIAP1,for
R13323 T16970 T16969 punct ",",cIAP1
R13324 T16971 T16969 appos TRAF2,cIAP1
R13325 T16972 T16969 punct ",",cIAP1
R13326 T16973 T16969 appos TRAF3,cIAP1
R13327 T16974 T16964 punct ",",probed
R13328 T16975 T16964 cc and,probed
R13329 T16976 T16981 dep HOIP,indicated
R13330 T16977 T16981 punct (,indicated
R13331 T16978 T16980 amod approximate,weights
R13332 T16979 T16980 amod molecular,weights
R13333 T16980 T16981 nsubj weights,indicated
R13334 T16981 T16964 conj indicated,probed
R13335 T16982 T16981 prep on,indicated
R13336 T16983 T16982 pobj left,on
R13337 T16984 T16981 punct ),indicated
R13338 T16985 T16981 punct .,indicated
R13339 T16986 T16987 amod Similar,results
R13340 T16987 T16989 nsubjpass results,obtained
R13341 T16988 T16989 auxpass were,obtained
R13342 T16989 T16989 ROOT obtained,obtained
R13343 T16990 T16989 prep in,obtained
R13344 T16991 T16993 nummod two,experiments
R13345 T16992 T16993 amod additional,experiments
R13346 T16993 T16990 pobj experiments,in
R13347 T16994 T16989 punct .,obtained
R13348 T16995 T16998 punct (,CD40
R13349 T16996 T16998 nmod B,CD40
R13350 T16997 T16998 punct ),CD40
R13351 T16998 T17000 nsubjpass CD40,isolated
R13352 T16999 T17000 auxpass was,isolated
R13353 T17000 T17000 ROOT isolated,isolated
R13354 T17001 T17000 agent by,isolated
R13355 T17002 T17001 pobj immunoprecipitation,by
R13356 T17003 T17004 punct (,as
R13357 T17004 T17000 prep as,isolated
R13358 T17005 T17004 prep in,as
R13359 T17006 T17007 punct (,A
R13360 T17007 T17005 pobj A,in
R13361 T17008 T17007 punct ),A
R13362 T17009 T17004 punct ),as
R13363 T17010 T17000 prep from,isolated
R13364 T17011 T17014 nummod A20,cells
R13365 T17012 T17014 nummod .2,cells
R13366 T17013 T17014 compound J,cells
R13367 T17014 T17010 pobj cells,from
R13368 T17015 T17014 cc and,cells
R13369 T17016 T17017 amod HOIP-deficient,cells
R13370 T17017 T17014 conj cells,cells
R13371 T17018 T17000 conj transduced,isolated
R13372 T17019 T17022 det an,vector
R13373 T17020 T17022 amod empty,vector
R13374 T17021 T17022 compound retroviral,vector
R13375 T17022 T16926 pobj vector,with
R13376 T17023 T17022 punct (,vector
R13377 T17024 T17022 appos pMIP,vector
R13378 T17025 T17022 punct ),vector
R13379 T17026 T17022 cc or,vector
R13380 T17027 T17029 det a,vector
R13381 T17028 T17029 amod retroviral,vector
R13382 T17029 T17022 conj vector,vector
R13383 T17030 T17018 advcl encoding,transduced
R13384 T17031 T17030 dobj HOIP,encoding
R13385 T17032 T17000 punct .,isolated
R13386 T17033 T17034 compound Material,immunoprecipitated
R13387 T17034 T17047 nsubjpass immunoprecipitated,examined
R13388 T17035 T17034 prep with,immunoprecipitated
R13389 T17036 T17045 det an,antibody
R13390 T17037 T17038 amod isotype,control
R13391 T17038 T17045 nmod control,antibody
R13392 T17039 T17045 nmod antibody,antibody
R13393 T17040 T17041 punct (,isotype
R13394 T17041 T17045 nmod isotype,antibody
R13395 T17042 T17041 punct ),isotype
R13396 T17043 T17041 cc or,isotype
R13397 T17044 T17045 amod anti-CD40,antibody
R13398 T17045 T17035 pobj antibody,with
R13399 T17046 T17047 auxpass was,examined
R13400 T17047 T17047 ROOT examined,examined
R13401 T17048 T17047 agent by,examined
R13402 T17049 T17050 amod Western,blotting
R13403 T17050 T17048 pobj blotting,by
R13404 T17051 T17050 prep for,blotting
R13405 T17052 T17051 pobj CD40,for
R13406 T17053 T17052 punct ",",CD40
R13407 T17054 T17052 appos TRAF2,CD40
R13408 T17055 T17052 punct ",",CD40
R13409 T17056 T17052 appos TRAF3,CD40
R13410 T17057 T17052 punct ",",CD40
R13411 T17058 T17052 conj cIAP1,CD40
R13412 T17059 T17058 punct ",",cIAP1
R13413 T17060 T17058 conj HOIP,cIAP1
R13414 T17061 T17060 punct ",",HOIP
R13415 T17062 T17064 compound IKKα,β
R13416 T17063 T17064 compound /,β
R13417 T17064 T17060 conj β,HOIP
R13418 T17065 T17064 punct ",",β
R13419 T17066 T17064 cc and,β
R13420 T17067 T17064 conj IKKγ,β
R13421 T17068 T17070 punct (,panels
R13422 T17069 T17070 amod right,panels
R13423 T17070 T17067 appos panels,IKKγ
R13424 T17071 T17067 punct ),IKKγ
R13425 T17072 T17047 punct .,examined
R13426 T17073 T17074 compound HOIP,expression
R13427 T17074 T17076 nsubjpass expression,required
R13428 T17075 T17076 auxpass was,required
R13429 T17076 T17076 ROOT required,required
R13430 T17077 T17076 prep for,required
R13431 T17078 T17077 pobj coprecipitation,for
R13432 T17079 T17078 prep of,coprecipitation
R13433 T17080 T17081 compound IKK,proteins
R13434 T17081 T17079 pobj proteins,of
R13435 T17082 T17076 prep with,required
R13436 T17083 T17082 pobj CD40,with
R13437 T17084 T17076 punct .,required
R13438 T17085 T17086 nsubj Cell,lysates
R13439 T17086 T17086 ROOT lysates,lysates
R13440 T17087 T17086 prep from,lysates
R13441 T17088 T17089 amod unstimulated,cells
R13442 T17089 T17087 pobj cells,from
R13443 T17090 T17091 auxpass are,shown
R13444 T17091 T17086 conj shown,lysates
R13445 T17092 T17091 prep in,shown
R13446 T17093 T17095 det the,panels
R13447 T17094 T17095 amod left,panels
R13448 T17095 T17092 pobj panels,in
R13449 T17096 T17086 punct .,lysates
R13450 T17097 T17098 amod Similar,results
R13451 T17098 T17100 nsubjpass results,obtained
R13452 T17099 T17100 auxpass were,obtained
R13453 T17100 T17100 ROOT obtained,obtained
R13454 T17101 T17100 prep in,obtained
R13455 T17102 T17104 det a,experiment
R13456 T17103 T17104 amod second,experiment
R13457 T17104 T17101 pobj experiment,in
R13458 T17105 T17101 cc and,in
R13459 T17106 T17101 conj in,in
R13460 T17107 T17108 nummod two,experiments
R13461 T17108 T17106 pobj experiments,in
R13462 T17109 T17108 prep with,experiments
R13463 T17110 T17113 det a,clone
R13464 T17111 T17113 amod second,clone
R13465 T17112 T17113 amod HOIP-deficient,clone
R13466 T17113 T17109 pobj clone,with
R13467 T17114 T17100 punct .,obtained
R13468 T17115 T17116 punct (,C
R13469 T17116 T17116 ROOT C,C
R13470 T17117 T17116 punct ),C
R13471 T17118 T17200 pobj blotting,by
R13472 T17119 T17121 aux To,evaluate
R13473 T17120 T17121 advmod further,evaluate
R13474 T17121 T17138 advcl evaluate,/
R13475 T17122 T17123 amod HOIP-dependent,recruitment
R13476 T17123 T17121 dobj recruitment,evaluate
R13477 T17124 T17123 prep of,recruitment
R13478 T17125 T17124 pobj IKKγ,of
R13479 T17126 T17121 prep to,evaluate
R13480 T17127 T17126 pobj CD40,to
R13481 T17128 T17127 punct ",",CD40
R13482 T17129 T17138 ccomp A20,/
R13483 T17130 T17132 nummod .2,cells
R13484 T17131 T17132 compound J,cells
R13485 T17132 T17129 dobj cells,A20
R13486 T17133 T17132 cc or,cells
R13487 T17134 T17132 conj HOIP-deficient,cells
R13488 T17135 T17134 punct (,HOIP-deficient
R13489 T17136 T17138 punct HOIP,/
R13490 T17137 T17138 punct -,/
R13491 T17138 T17138 ROOT /,/
R13492 T17139 T17138 punct -,/
R13493 T17140 T17138 punct ),/
R13494 T17141 T17144 nummod A20,cells
R13495 T17142 T17144 nummod .2,cells
R13496 T17143 T17144 compound J,cells
R13497 T17144 T17146 nsubjpass cells,transduced
R13498 T17145 T17146 auxpass were,transduced
R13499 T17146 T17146 ROOT transduced,transduced
R13500 T17147 T17146 prep with,transduced
R13501 T17148 T17151 det an,vector
R13502 T17149 T17151 amod empty,vector
R13503 T17150 T17151 compound retroviral,vector
R13504 T17151 T17147 pobj vector,with
R13505 T17152 T17151 cc or,vector
R13506 T17153 T17155 det a,construct
R13507 T17154 T17155 amod retroviral,construct
R13508 T17155 T17146 advcl construct,transduced
R13509 T17156 T17155 xcomp encoding,construct
R13510 T17157 T17159 compound BP,IKKγ
R13511 T17158 T17159 compound epitope-tagged,IKKγ
R13512 T17159 T17156 dobj IKKγ,encoding
R13513 T17160 T17161 punct (,noted
R13514 T17161 T17156 advcl noted,encoding
R13515 T17162 T17161 prep in,noted
R13516 T17163 T17164 det the,figure
R13517 T17164 T17162 pobj figure,in
R13518 T17165 T17164 prep as,figure
R13519 T17166 T17165 pobj pMIP,as
R13520 T17167 T17166 cc and,pMIP
R13521 T17168 T17166 conj IKKγ,pMIP
R13522 T17169 T17168 punct ",",IKKγ
R13523 T17170 T17168 conj respectively,IKKγ
R13524 T17171 T17161 punct ),noted
R13525 T17172 T17146 punct .,transduced
R13526 T17173 T17173 ROOT Lysates,Lysates
R13527 T17174 T17175 punct (,lanes
R13528 T17175 T17175 ROOT lanes,lanes
R13529 T17176 T17175 nummod 1,lanes
R13530 T17177 T17184 nmod 3,samples
R13531 T17178 T17177 punct ),3
R13532 T17179 T17177 cc and,3
R13533 T17180 T17177 conj immunoprecipitation,3
R13534 T17181 T17182 punct (,IP
R13535 T17182 T17180 appos IP,immunoprecipitation
R13536 T17183 T17180 punct ),immunoprecipitation
R13537 T17184 T17195 nsubjpass samples,fractionated
R13538 T17185 T17186 punct (,lanes
R13539 T17186 T17184 parataxis lanes,samples
R13540 T17187 T17186 nummod 4,lanes
R13541 T17188 T17186 appos 11,lanes
R13542 T17189 T17186 punct ),lanes
R13543 T17190 T17184 prep from,samples
R13544 T17191 T17193 det the,lines
R13545 T17192 T17193 compound cell,lines
R13546 T17193 T17190 pobj lines,from
R13547 T17194 T17195 auxpass were,fractionated
R13548 T17195 T17195 ROOT fractionated,fractionated
R13549 T17196 T17195 agent by,fractionated
R13550 T17197 T17196 pobj SDS-PAGE,by
R13551 T17198 T17195 cc and,fractionated
R13552 T17199 T17195 conj evaluated,fractionated
R13553 T17200 T17199 agent by,evaluated
R13554 T17201 T17118 amod Western,blotting
R13555 T17202 T17118 prep with,blotting
R13556 T17203 T17202 pobj antibodies,with
R13557 T17204 T17199 prep to,evaluated
R13558 T17205 T17207 det the,tag
R13559 T17206 T17207 compound BP,tag
R13560 T17207 T17204 pobj tag,to
R13561 T17208 T17209 punct (,IKKγ
R13562 T17209 T17207 appos IKKγ,tag
R13563 T17210 T17209 punct ",",IKKγ
R13564 T17211 T17212 amod upper,panel
R13565 T17212 T17209 appos panel,IKKγ
R13566 T17213 T17209 punct ),IKKγ
R13567 T17214 T17207 cc and,tag
R13568 T17215 T17207 conj TRAF2,tag
R13569 T17216 T17195 punct .,fractionated
R13570 T17217 T17220 det The,sample
R13571 T17218 T17220 amod anti-CD40,sample
R13572 T17219 T17220 amod IP,sample
R13573 T17220 T17225 nsubjpass sample,treated
R13574 T17221 T17220 prep in,sample
R13575 T17222 T17221 pobj lane,in
R13576 T17223 T17222 nummod 11,lane
R13577 T17224 T17225 auxpass was,treated
R13578 T17225 T17235 ccomp treated,was
R13579 T17226 T17225 prep with,treated
R13580 T17227 T17228 amod λ,phosphatase
R13581 T17228 T17226 pobj phosphatase,with
R13582 T17229 T17235 punct ;,was
R13583 T17230 T17231 det the,sample
R13584 T17231 T17235 nsubj sample,was
R13585 T17232 T17231 prep in,sample
R13586 T17233 T17232 pobj lane,in
R13587 T17234 T17233 nummod 10,lane
R13588 T17235 T17235 ROOT was,was
R13589 T17236 T17235 attr mock-treated,was
R13590 T17237 T17235 punct .,was
R13591 T17238 T17239 compound Protein,samples
R13592 T17239 T17249 nsubjpass samples,fractionated
R13593 T17240 T17239 punct (,samples
R13594 T17241 T17242 acomp minus,those
R13595 T17242 T17239 appos those,samples
R13596 T17243 T17242 acl treated,those
R13597 T17244 T17243 prep with,treated
R13598 T17245 T17244 pobj phosphatase,with
R13599 T17246 T17239 punct ),samples
R13600 T17247 T17249 auxpass were,fractionated
R13601 T17248 T17249 advmod also,fractionated
R13602 T17249 T17249 ROOT fractionated,fractionated
R13603 T17250 T17249 prep on,fractionated
R13604 T17251 T17253 det a,gel
R13605 T17252 T17253 amod separate,gel
R13606 T17253 T17250 pobj gel,on
R13607 T17254 T17253 punct (,gel
R13608 T17255 T17257 amod lower,concentration
R13609 T17256 T17257 compound acrylamide,concentration
R13610 T17257 T17253 appos concentration,gel
R13611 T17258 T17253 punct ),gel
R13612 T17259 T17249 prep for,fractionated
R13613 T17260 T17261 det the,evaluation
R13614 T17261 T17259 pobj evaluation,for
R13615 T17262 T17261 prep of,evaluation
R13616 T17263 T17262 pobj TRAF3,of
R13617 T17264 T17263 cc and,TRAF3
R13618 T17265 T17263 conj HOIP,TRAF3
R13619 T17266 T17269 punct (,panels
R13620 T17267 T17269 amod bottom,panels
R13621 T17268 T17269 nummod two,panels
R13622 T17269 T17265 appos panels,HOIP
R13623 T17270 T17265 punct ),HOIP
R13624 T17271 T17249 punct .,fractionated
R13625 T17272 T17273 amod Similar,results
R13626 T17273 T17275 nsubjpass results,obtained
R13627 T17274 T17275 auxpass were,obtained
R13628 T17275 T17275 ROOT obtained,obtained
R13629 T17276 T17275 prep in,obtained
R13630 T17277 T17279 nummod two,experiments
R13631 T17278 T17279 amod additional,experiments
R13632 T17279 T17276 pobj experiments,in
R13633 T17280 T17275 punct .,obtained

GO-BP

Id Subject Object Predicate Lexical cue
T8280 5090-5093 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T8281 99-114 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T8282 119-128 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T8283 239-248 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T8284 339-348 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T8285 936-945 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T8286 4259-4268 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T8287 4314-4323 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T8288 4424-4433 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T8289 5277-5286 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T8290 781-790 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T8291 781-790 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T8292 1531-1539 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T8293 1656-1687 http://purl.obolibrary.org/obo/GO_0043687 denotes post-translational modification
T8294 6830-6862 http://purl.obolibrary.org/obo/GO_0043687 denotes post-translational modifications
T8295 1656-1687 http://purl.obolibrary.org/obo/GO_1901873 denotes post-translational modification
T8296 6830-6862 http://purl.obolibrary.org/obo/GO_1901873 denotes post-translational modifications
T8297 1656-1687 http://purl.obolibrary.org/obo/GO_1901874 denotes post-translational modification
T8298 6830-6862 http://purl.obolibrary.org/obo/GO_1901874 denotes post-translational modifications
T8299 1656-1687 http://purl.obolibrary.org/obo/GO_1901875 denotes post-translational modification
T8300 6830-6862 http://purl.obolibrary.org/obo/GO_1901875 denotes post-translational modifications
T8301 6229-6240 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T8302 6557-6568 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T8303 6678-6693 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T17748 1763-1766 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T17749 3115-3118 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T17750 1791-1800 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T17751 3869-3880 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T17752 3964-3975 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase

GO-MF

Id Subject Object Predicate Lexical cue
T8305 5090-5093 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T8306 989-997 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T8307 1264-1272 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T8308 5890-5898 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T8309 6229-6240 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T8310 6557-6568 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T17753 1763-1766 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T17754 3115-3118 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T17755 2320-2328 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T17756 2919-2927 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T17757 2951-2959 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T17758 3759-3769 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T17759 3869-3880 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T17760 3964-3975 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase

GO-CC

Id Subject Object Predicate Lexical cue
T17777 3759-3769 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T17761 1840-1845 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17762 1951-1956 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17763 2748-2753 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17764 2773-2778 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17765 3170-3175 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17766 3393-3398 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17767 3434-3439 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17768 3679-3683 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T17769 1991-1999 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T17770 2320-2328 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T17771 2919-2927 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T17772 2951-2959 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T17773 3759-3769 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T17774 2320-2328 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T17775 2919-2927 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T17776 2951-2959 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T8312 99-103 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T8313 1383-1387 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T8314 5442-5446 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T8315 5546-5550 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T8316 6450-6454 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T8317 737-745 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T8318 989-997 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T8319 1264-1272 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T8320 5890-5898 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T8321 989-997 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T8322 1264-1272 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T8323 5890-5898 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody

sentences

Id Subject Object Predicate Lexical cue
T6706 63-275 Sentence denotes The marked defects in CD40-mediated cell activation and signaling displayed by HOIP-deficient cells suggested that HOIP mediates recruitment of critical components of the CD40 signaling apparatus to the receptor.
T6707 276-441 Sentence denotes Previously, we demonstrated that HOIP is recruited to the CD40 signaling complex in a TRAF2-dependent manner, suggesting that HOIP functions downstream of TRAF2 [6].
T6708 442-581 Sentence denotes Studies by others suggest that the TRAF2-associated proteins cIAP1 and cIAP2 play a role in the recruitment of HOIP to TNFR1 and CD40 [14].
T6709 582-811 Sentence denotes Therefore, we determined whether the association of HOIP with CD40 in A20.2J cells was altered by treatment of cells with an inhibitor of cIAP activity, a membrane-permeable peptide derived from the apoptosis regulator SMAC [15].
T6710 812-1021 Sentence denotes We found that pretreatment of cells with the SMAC peptide dramatically reduced the amount of cIAP1 associated with the CD40 signaling complex in cells stimulated with anti-CD40 antibody-coated beads (Fig. 5A).
T6711 1022-1273 Sentence denotes SMAC peptide treatment also resulted in a slight but reproducible decrease in the amount of the major HOIP form recovered by CD40 immunoprecipitation, along with an apparent increase in higher molecular weight species recognized by anti-HOIP antibody.
T6712 1274-1396 Sentence denotes In contrast, treatment with the SMAC peptide did not alter the amount or molecular weight of HOIP present in cell lysates.
T6713 1397-1561 Sentence denotes These data suggest that SMAC peptide treatment specifically alters the characteristics of CD40-associated HOIP rather than the entire cellular pool of this protein.
T6714 1562-1718 Sentence denotes Together, these results support the idea that the cIAP proteins influence the recruitment and post-translational modification state of CD40-associated HOIP.
T6715 4172-4393 Sentence denotes To test the possibility that HOIP is responsible for the recruitment of other critical signaling proteins to CD40, we immunoprecipitated CD40 signaling complexes from HOIP-deficient and HOIP-reconstituted cells (Fig. 5B).
T6716 4394-4542 Sentence denotes As described previously, CD40 signaling complexes immunoprecipitated from A20.2J cells contained HOIP as well as TRAF2, TRAF3, IKKα/β, and IKKγ [6].
T6717 4543-4770 Sentence denotes The amounts of TRAF2, TRAF3, and cIAP1 in CD40 immunoprecipitates from HOIP-deficient cells were similar to those from parental A20.2J cells, indicating that HOIP is not required for the association of these proteins with CD40.
T6718 4771-4895 Sentence denotes In contrast, IKKα/β and IKKγ were not detectable in CD40 immunoprecipitates recovered from HOIP-deficient cells (Fig. 5B,C).
T6719 4896-5174 Sentence denotes The amounts of IKKα/β and IKKγ in CD40 immunoprecipitates from HOIP-reconstituted cells were similar to those detected in samples prepared from parental cells, demonstrating that the defects in IKK recruitment we observed were due specifically to the absence of HOIP expression.
T6720 5175-5295 Sentence denotes These data indicate that HOIP is required for recruitment of the NF-κB-activating complex to the CD40 signaling complex.
T6721 5296-5455 Sentence denotes As shown here and in our previous study [6], IKKγ present in CD40 immunoprecipitates appears to have a higher molecular weight than that found in cell lysates.
T6722 5456-5659 Sentence denotes To confirm that this higher molecular weight species was indeed IKKγ, we generated A20.2J cell lines containing a stably integrated retroviral vector that encoded an epitope-tagged version of mouse IKKγ.
T6723 5660-5791 Sentence denotes Cell lysates and CD40 immunoprecipitates prepared from these cells were analyzed by Western blotting for the epitope tag (Fig. 5C).
T6724 5792-5959 Sentence denotes This analysis produced a pattern of bands that was essentially the same as that obtained using an antibody specific for native IKKγ (compare panels B and C in Fig. 5).
T6725 5960-6076 Sentence denotes Moreover, analysis of cells expressing epitope tagged-IKKγ confirmed that recruitment of IKKγ to CD40 requires HOIP.
T6726 6077-6331 Sentence denotes To determine what was responsible for the increased molecular weight of IKKγ in CD40 immunoprecipitates, the protein samples were incubated with lambda phosphatase, which removes phosphates attached to tyrosine, threonine, or serine residues in proteins.
T6727 6332-6473 Sentence denotes This treatment reduced much of CD40-associated IKKγ to an apparent molecular weight similar to that of the protein in cell lysates (Fig. 5C).
T6728 6474-6694 Sentence denotes However, at least one band of significantly higher molecular weight remained after phosphatase treatment, suggesting that CD40-associated IKKγ is subject to at least one other modification in addition to phosphorylation.
T6729 6695-6871 Sentence denotes Overall, these data demonstrate that HOIP is required for the association of IKKγ with CD40, and suggest that this event is coupled to post-translational modifications of IKKγ.
T16813 1763-1846 Sentence denotes IKK recruitment to the CD40 signaling complex is defective in HOIP-deficient cells.
T16814 1847-1943 Sentence denotes (A) SMAC peptide treatment reduces recruitment of cIAP1 to CD40 and may modify HOIP recruitment.
T16815 1944-2070 Sentence denotes A20.2J cells were incubated for six hours with membrane-permeable SMAC-N7 peptide or 1.5% DMSO (solvent used for the peptide).
T16816 2071-2197 Sentence denotes Following the incubation, cell lysates were prepared, fractionated by SDS-PAGE, and evaluated by Western blot (lanes 1 and 2).
T16817 2198-2329 Sentence denotes Cells incubated with DMSO or SMAC-N7 were also stimulated with magnetic beads coated with anti-CD40 or an isotype control antibody.
T16818 2330-2406 Sentence denotes Immunoprecipitated (IP) material bound to the beads was loaded in lanes 3-5.
T16819 2407-2481 Sentence denotes Samples of the cell lysates after immunoprecipitation appear in lanes 6–8.
T16820 2482-2617 Sentence denotes Western blots were probed with antibodies specific for cIAP1, TRAF2, TRAF3, and HOIP (approximate molecular weights indicated on left).
T16821 2618-2866 Sentence denotes Similar results were obtained in two additional experiments. (B) CD40 was isolated by immunoprecipitation (as in (A)) from A20.2J cells and HOIP-deficient cells transduced with an empty retroviral vector (pMIP) or a retroviral vector encoding HOIP.
T16822 2867-3062 Sentence denotes Material immunoprecipitated with an isotype control antibody (isotype) or anti-CD40 antibody was examined by Western blotting for CD40, TRAF2, TRAF3, cIAP1, HOIP, IKKα/β, and IKKγ (right panels).
T16823 3063-3138 Sentence denotes HOIP expression was required for coprecipitation of IKK proteins with CD40.
T16824 3139-3205 Sentence denotes Cell lysates from unstimulated cells are shown in the left panels.
T16825 3206-3599 Sentence denotes Similar results were obtained in a second experiment and in two experiments with a second HOIP-deficient clone. (C) To further evaluate HOIP-dependent recruitment of IKKγ to CD40, A20.2J cells or HOIP-deficient (HOIP-/-) A20.2J cells were transduced with an empty retroviral vector or a retroviral construct encoding BP epitope-tagged IKKγ (noted in the figure as pMIP and IKKγ, respectively).
T16826 3600-3814 Sentence denotes Lysates (lanes 1–3) and immunoprecipitation (IP) samples (lanes 4–11) from the cell lines were fractionated by SDS-PAGE and evaluated by Western blotting with antibodies to the BP tag (IKKγ, upper panel) and TRAF2.
T16827 3815-3921 Sentence denotes The anti-CD40 IP sample in lane 11 was treated with λ phosphatase; the sample in lane 10 was mock-treated.
T16828 3922-4108 Sentence denotes Protein samples (minus those treated with phosphatase) were also fractionated on a separate gel (lower acrylamide concentration) for the evaluation of TRAF3 and HOIP (bottom two panels).
T16829 4109-4169 Sentence denotes Similar results were obtained in two additional experiments.
T107 0-62 Sentence denotes HOIP is necessary for association of the IKK complex with CD40
T108 63-275 Sentence denotes The marked defects in CD40-mediated cell activation and signaling displayed by HOIP-deficient cells suggested that HOIP mediates recruitment of critical components of the CD40 signaling apparatus to the receptor.
T109 276-441 Sentence denotes Previously, we demonstrated that HOIP is recruited to the CD40 signaling complex in a TRAF2-dependent manner, suggesting that HOIP functions downstream of TRAF2 [6].
T110 442-581 Sentence denotes Studies by others suggest that the TRAF2-associated proteins cIAP1 and cIAP2 play a role in the recruitment of HOIP to TNFR1 and CD40 [14].
T111 582-811 Sentence denotes Therefore, we determined whether the association of HOIP with CD40 in A20.2J cells was altered by treatment of cells with an inhibitor of cIAP activity, a membrane-permeable peptide derived from the apoptosis regulator SMAC [15].
T112 812-1021 Sentence denotes We found that pretreatment of cells with the SMAC peptide dramatically reduced the amount of cIAP1 associated with the CD40 signaling complex in cells stimulated with anti-CD40 antibody-coated beads (Fig. 5A).
T113 1022-1273 Sentence denotes SMAC peptide treatment also resulted in a slight but reproducible decrease in the amount of the major HOIP form recovered by CD40 immunoprecipitation, along with an apparent increase in higher molecular weight species recognized by anti-HOIP antibody.
T114 1274-1396 Sentence denotes In contrast, treatment with the SMAC peptide did not alter the amount or molecular weight of HOIP present in cell lysates.
T115 1397-1561 Sentence denotes These data suggest that SMAC peptide treatment specifically alters the characteristics of CD40-associated HOIP rather than the entire cellular pool of this protein.
T116 1562-1718 Sentence denotes Together, these results support the idea that the cIAP proteins influence the recruitment and post-translational modification state of CD40-associated HOIP.
T117 1719-1846 Sentence denotes 10.1371/journal.pone.0023061.g005 Figure 5 IKK recruitment to the CD40 signaling complex is defective in HOIP-deficient cells.
T118 1847-1943 Sentence denotes (A) SMAC peptide treatment reduces recruitment of cIAP1 to CD40 and may modify HOIP recruitment.
T119 1944-2070 Sentence denotes A20.2J cells were incubated for six hours with membrane-permeable SMAC-N7 peptide or 1.5% DMSO (solvent used for the peptide).
T120 2071-2197 Sentence denotes Following the incubation, cell lysates were prepared, fractionated by SDS-PAGE, and evaluated by Western blot (lanes 1 and 2).
T121 2198-2329 Sentence denotes Cells incubated with DMSO or SMAC-N7 were also stimulated with magnetic beads coated with anti-CD40 or an isotype control antibody.
T122 2330-2406 Sentence denotes Immunoprecipitated (IP) material bound to the beads was loaded in lanes 3-5.
T123 2407-2481 Sentence denotes Samples of the cell lysates after immunoprecipitation appear in lanes 6–8.
T124 2482-2617 Sentence denotes Western blots were probed with antibodies specific for cIAP1, TRAF2, TRAF3, and HOIP (approximate molecular weights indicated on left).
T125 2618-2866 Sentence denotes Similar results were obtained in two additional experiments. (B) CD40 was isolated by immunoprecipitation (as in (A)) from A20.2J cells and HOIP-deficient cells transduced with an empty retroviral vector (pMIP) or a retroviral vector encoding HOIP.
T126 2867-3062 Sentence denotes Material immunoprecipitated with an isotype control antibody (isotype) or anti-CD40 antibody was examined by Western blotting for CD40, TRAF2, TRAF3, cIAP1, HOIP, IKKα/β, and IKKγ (right panels).
T127 3063-3138 Sentence denotes HOIP expression was required for coprecipitation of IKK proteins with CD40.
T128 3139-3205 Sentence denotes Cell lysates from unstimulated cells are shown in the left panels.
T129 3206-3599 Sentence denotes Similar results were obtained in a second experiment and in two experiments with a second HOIP-deficient clone. (C) To further evaluate HOIP-dependent recruitment of IKKγ to CD40, A20.2J cells or HOIP-deficient (HOIP-/-) A20.2J cells were transduced with an empty retroviral vector or a retroviral construct encoding BP epitope-tagged IKKγ (noted in the figure as pMIP and IKKγ, respectively).
T130 3600-3814 Sentence denotes Lysates (lanes 1–3) and immunoprecipitation (IP) samples (lanes 4–11) from the cell lines were fractionated by SDS-PAGE and evaluated by Western blotting with antibodies to the BP tag (IKKγ, upper panel) and TRAF2.
T131 3815-3921 Sentence denotes The anti-CD40 IP sample in lane 11 was treated with λ phosphatase; the sample in lane 10 was mock-treated.
T132 3922-4108 Sentence denotes Protein samples (minus those treated with phosphatase) were also fractionated on a separate gel (lower acrylamide concentration) for the evaluation of TRAF3 and HOIP (bottom two panels).
T133 4109-4169 Sentence denotes Similar results were obtained in two additional experiments.
T134 4172-4393 Sentence denotes To test the possibility that HOIP is responsible for the recruitment of other critical signaling proteins to CD40, we immunoprecipitated CD40 signaling complexes from HOIP-deficient and HOIP-reconstituted cells (Fig. 5B).
T135 4394-4542 Sentence denotes As described previously, CD40 signaling complexes immunoprecipitated from A20.2J cells contained HOIP as well as TRAF2, TRAF3, IKKα/β, and IKKγ [6].
T136 4543-4770 Sentence denotes The amounts of TRAF2, TRAF3, and cIAP1 in CD40 immunoprecipitates from HOIP-deficient cells were similar to those from parental A20.2J cells, indicating that HOIP is not required for the association of these proteins with CD40.
T137 4771-4895 Sentence denotes In contrast, IKKα/β and IKKγ were not detectable in CD40 immunoprecipitates recovered from HOIP-deficient cells (Fig. 5B,C).
T138 4896-5174 Sentence denotes The amounts of IKKα/β and IKKγ in CD40 immunoprecipitates from HOIP-reconstituted cells were similar to those detected in samples prepared from parental cells, demonstrating that the defects in IKK recruitment we observed were due specifically to the absence of HOIP expression.
T139 5175-5295 Sentence denotes These data indicate that HOIP is required for recruitment of the NF-κB-activating complex to the CD40 signaling complex.
T140 5296-5455 Sentence denotes As shown here and in our previous study [6], IKKγ present in CD40 immunoprecipitates appears to have a higher molecular weight than that found in cell lysates.
T141 5456-5659 Sentence denotes To confirm that this higher molecular weight species was indeed IKKγ, we generated A20.2J cell lines containing a stably integrated retroviral vector that encoded an epitope-tagged version of mouse IKKγ.
T142 5660-5791 Sentence denotes Cell lysates and CD40 immunoprecipitates prepared from these cells were analyzed by Western blotting for the epitope tag (Fig. 5C).
T143 5792-5959 Sentence denotes This analysis produced a pattern of bands that was essentially the same as that obtained using an antibody specific for native IKKγ (compare panels B and C in Fig. 5).
T144 5960-6076 Sentence denotes Moreover, analysis of cells expressing epitope tagged-IKKγ confirmed that recruitment of IKKγ to CD40 requires HOIP.
T145 6077-6331 Sentence denotes To determine what was responsible for the increased molecular weight of IKKγ in CD40 immunoprecipitates, the protein samples were incubated with lambda phosphatase, which removes phosphates attached to tyrosine, threonine, or serine residues in proteins.
T146 6332-6473 Sentence denotes This treatment reduced much of CD40-associated IKKγ to an apparent molecular weight similar to that of the protein in cell lysates (Fig. 5C).
T147 6474-6694 Sentence denotes However, at least one band of significantly higher molecular weight remained after phosphatase treatment, suggesting that CD40-associated IKKγ is subject to at least one other modification in addition to phosphorylation.
T148 6695-6871 Sentence denotes Overall, these data demonstrate that HOIP is required for the association of IKKγ with CD40, and suggest that this event is coupled to post-translational modifications of IKKγ.

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T8191 58-62 P25942 denotes CD40
T8192 85-89 P25942 denotes CD40
T8193 142-146 Q96EP0 denotes HOIP
T8194 178-182 Q96EP0 denotes HOIP
T8195 234-238 P25942 denotes CD40
T8196 309-313 Q96EP0 denotes HOIP
T8197 334-338 P25942 denotes CD40
T8198 362-367 Q12933 denotes TRAF2
T8199 402-406 Q96EP0 denotes HOIP
T8200 431-436 Q12933 denotes TRAF2
T8201 477-482 Q12933 denotes TRAF2
T8202 503-508 Q13490 denotes cIAP1
T8203 553-557 Q96EP0 denotes HOIP
T8204 571-575 P25942 denotes CD40
T8205 634-638 Q96EP0 denotes HOIP
T8206 644-648 P25942 denotes CD40
T8207 652-655 P21580 denotes A20
T8208 905-910 Q13490 denotes cIAP1
T8209 931-935 P25942 denotes CD40
T8210 984-988 P25942 denotes CD40
T8211 1124-1128 Q96EP0 denotes HOIP
T8212 1147-1151 P25942 denotes CD40
T8213 1259-1263 Q96EP0 denotes HOIP
T8214 1367-1371 Q96EP0 denotes HOIP
T8215 1487-1491 P25942 denotes CD40
T8216 1503-1507 Q96EP0 denotes HOIP
T8217 1697-1701 P25942 denotes CD40
T8218 1713-1717 Q96EP0 denotes HOIP
T8219 4201-4205 Q96EP0 denotes HOIP
T8220 4281-4285 P25942 denotes CD40
T8221 4309-4313 P25942 denotes CD40
T8222 4339-4343 Q96EP0 denotes HOIP
T8223 4358-4362 Q96EP0 denotes HOIP
T8224 4419-4423 P25942 denotes CD40
T8225 4468-4471 P21580 denotes A20
T8226 4491-4495 Q96EP0 denotes HOIP
T8227 4507-4512 Q12933 denotes TRAF2
T8228 4514-4519 Q13114 denotes TRAF3
T8229 4558-4563 Q12933 denotes TRAF2
T8230 4565-4570 Q13114 denotes TRAF3
T8231 4576-4581 Q13490 denotes cIAP1
T8232 4585-4589 P25942 denotes CD40
T8233 4614-4618 Q96EP0 denotes HOIP
T8234 4671-4674 P21580 denotes A20
T8235 4701-4705 Q96EP0 denotes HOIP
T8236 4765-4769 P25942 denotes CD40
T8237 4823-4827 P25942 denotes CD40
T8238 4862-4866 Q96EP0 denotes HOIP
T8239 4930-4934 P25942 denotes CD40
T8240 4959-4963 Q96EP0 denotes HOIP
T8241 5158-5162 Q96EP0 denotes HOIP
T8242 5200-5204 Q96EP0 denotes HOIP
T8243 5272-5276 P25942 denotes CD40
T8244 5357-5361 P25942 denotes CD40
T8245 5539-5542 P21580 denotes A20
T8246 5677-5681 P25942 denotes CD40
T8247 6057-6061 P25942 denotes CD40
T8248 6071-6075 Q96EP0 denotes HOIP
T8249 6157-6161 P25942 denotes CD40
T8250 6363-6367 P25942 denotes CD40
T8251 6596-6600 P25942 denotes CD40
T8252 6732-6736 Q96EP0 denotes HOIP
T8253 6782-6786 P25942 denotes CD40
T17697 1786-1790 P25942 denotes CD40
T17698 1825-1829 Q96EP0 denotes HOIP
T17699 1897-1902 Q13490 denotes cIAP1
T17700 1906-1910 P25942 denotes CD40
T17701 1926-1930 Q96EP0 denotes HOIP
T17702 1944-1947 P21580 denotes A20
T17703 2293-2297 P25942 denotes CD40
T17704 2537-2542 Q13490 denotes cIAP1
T17705 2544-2549 Q12933 denotes TRAF2
T17706 2551-2556 Q13114 denotes TRAF3
T17707 2562-2566 Q96EP0 denotes HOIP
T17708 2683-2687 P25942 denotes CD40
T17709 2741-2744 P21580 denotes A20
T17710 2758-2762 Q96EP0 denotes HOIP
T17711 2861-2865 Q96EP0 denotes HOIP
T17712 2946-2950 P25942 denotes CD40
T17713 2997-3001 P25942 denotes CD40
T17714 3003-3008 Q12933 denotes TRAF2
T17715 3010-3015 Q13114 denotes TRAF3
T17716 3017-3022 Q13490 denotes cIAP1
T17717 3024-3028 Q96EP0 denotes HOIP
T17718 3063-3067 Q96EP0 denotes HOIP
T17719 3133-3137 P25942 denotes CD40
T17720 3296-3300 Q96EP0 denotes HOIP
T17721 3342-3346 Q96EP0 denotes HOIP
T17722 3380-3384 P25942 denotes CD40
T17723 3386-3389 P21580 denotes A20
T17724 3402-3406 Q96EP0 denotes HOIP
T17725 3418-3422 Q96EP0 denotes HOIP
T17726 3427-3430 P21580 denotes A20
T17727 3808-3813 Q12933 denotes TRAF2
T17728 3824-3828 P25942 denotes CD40
T17729 4073-4078 Q13114 denotes TRAF3
T17730 4083-4087 Q96EP0 denotes HOIP

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T6454 58-62 Protein denotes CD40
T6455 85-89 Protein denotes CD40
T6456 142-146 Protein denotes HOIP true
T6457 147-156 Negative_regulation denotes deficient
T6458 178-182 Protein denotes HOIP
T6459 309-313 Protein denotes HOIP
T6460 317-326 Binding denotes recruited
T6461 362-367 Protein denotes TRAF2
T6462 368-377 Regulation denotes dependent
T6463 402-406 Protein denotes HOIP
T6464 417-427 Regulation denotes downstream
T6465 431-436 Protein denotes TRAF2
T6466 477-482 Protein denotes TRAF2 true
T6467 483-493 Binding denotes associated
T6468 503-508 Protein denotes cIAP1
T6469 513-518 Protein denotes cIAP2
T6470 526-530 Regulation denotes role
T6471 538-549 Binding denotes recruitment
T6472 553-557 Protein denotes HOIP
T6473 561-566 Protein denotes TNFR1
T6474 571-575 Protein denotes CD40
T6475 619-630 Binding denotes association true
T6476 634-638 Protein denotes HOIP
T6477 644-648 Protein denotes CD40
T6478 669-676 Regulation denotes altered
T6479 707-716 Negative_regulation denotes inhibitor
T6480 883-890 Negative_regulation denotes reduced
T6481 905-910 Protein denotes cIAP1
T6482 911-921 Binding denotes associated
T6483 1088-1096 Negative_regulation denotes decrease true
T6484 1124-1128 Protein denotes HOIP
T6485 1147-1151 Protein denotes CD40
T6486 1327-1332 Regulation denotes alter
T6487 1367-1371 Protein denotes HOIP true
T6488 1457-1463 Regulation denotes alters
T6489 1487-1491 Protein denotes CD40 true
T6490 1492-1502 Binding denotes associated
T6491 1503-1507 Protein denotes HOIP true
T6492 1612-1616 Protein denotes cIAP
T6493 1626-1635 Regulation denotes influence
T6494 1640-1651 Binding denotes recruitment
T6495 1656-1687 Protein_modification denotes post-translational modification
T6496 1697-1701 Protein denotes CD40
T6497 1702-1712 Binding denotes associated
T6498 1713-1717 Protein denotes HOIP
T6499 4201-4205 Protein denotes HOIP
T6500 4209-4220 Positive_regulation denotes responsible
T6501 4229-4240 Binding denotes recruitment
T6502 4281-4285 Protein denotes CD40
T6503 4339-4343 Protein denotes HOIP
T6504 4344-4353 Negative_regulation denotes deficient
T6505 4358-4362 Protein denotes HOIP
T6506 4363-4376 Positive_regulation denotes reconstituted
T6507 4491-4495 Protein denotes HOIP
T6508 4507-4512 Protein denotes TRAF2
T6509 4514-4519 Protein denotes TRAF3
T6510 4521-4525 Protein denotes IKKα
T6511 4526-4527 Protein denotes β
T6512 4533-4537 Protein denotes IKKγ
T6513 4558-4563 Protein denotes TRAF2
T6514 4565-4570 Protein denotes TRAF3
T6515 4576-4581 Protein denotes cIAP1
T6516 4585-4589 Protein denotes CD40
T6517 4614-4618 Protein denotes HOIP
T6518 4619-4628 Negative_regulation denotes deficient
T6519 4701-4705 Protein denotes HOIP
T6520 4713-4721 Positive_regulation denotes required
T6521 4730-4741 Binding denotes association
T6522 4765-4769 Protein denotes CD40
T6523 4784-4788 Protein denotes IKKα
T6524 4789-4790 Protein denotes β
T6525 4795-4799 Protein denotes IKKγ
T6526 4823-4827 Protein denotes CD40
T6527 4862-4866 Protein denotes HOIP
T6528 4867-4876 Negative_regulation denotes deficient
T6529 4911-4915 Protein denotes IKKα
T6530 4916-4917 Protein denotes β
T6531 4922-4926 Protein denotes IKKγ
T6532 4930-4934 Protein denotes CD40
T6533 4959-4963 Protein denotes HOIP
T6534 4964-4977 Positive_regulation denotes reconstituted
T6535 5094-5105 Binding denotes recruitment
T6536 5147-5154 Negative_regulation denotes absence
T6537 5158-5162 Protein denotes HOIP
T6538 5163-5173 Gene_expression denotes expression
T6539 5200-5204 Protein denotes HOIP
T6540 5221-5232 Binding denotes recruitment
T6541 5341-5345 Protein denotes IKKγ
T6542 5357-5361 Protein denotes CD40
T6543 5520-5524 Protein denotes IKKγ
T6544 5654-5658 Protein denotes IKKγ
T6545 5677-5681 Protein denotes CD40
T6546 5919-5923 Protein denotes IKKγ
T6547 5988-5998 Gene_expression denotes expressing
T6548 6014-6018 Protein denotes IKKγ
T6549 6034-6045 Binding denotes recruitment
T6550 6049-6053 Protein denotes IKKγ
T6551 6057-6061 Protein denotes CD40
T6552 6062-6070 Positive_regulation denotes requires
T6553 6071-6075 Protein denotes HOIP
T6554 6119-6128 Positive_regulation denotes increased
T6555 6149-6153 Protein denotes IKKγ
T6556 6157-6161 Protein denotes CD40
T6557 6347-6354 Negative_regulation denotes reduced
T6558 6363-6367 Protein denotes CD40
T6559 6368-6378 Binding denotes associated
T6560 6379-6383 Protein denotes IKKγ
T6561 6596-6600 Protein denotes CD40
T6562 6601-6611 Binding denotes associated
T6563 6612-6616 Protein denotes IKKγ
T6564 6678-6693 Phosphorylation denotes phosphorylation
T6565 6732-6736 Protein denotes HOIP
T6566 6740-6748 Positive_regulation denotes required
T6567 6757-6768 Binding denotes association
T6568 6772-6776 Protein denotes IKKγ
T6569 6782-6786 Protein denotes CD40
T6570 6819-6826 Positive_regulation denotes coupled
T6571 6830-6848 Protein_modification denotes post-translational
T6572 6849-6862 Negative_regulation denotes modifications
T6573 6866-6870 Protein denotes IKKγ
T16721 1767-1778 Binding denotes recruitment
T16722 1825-1829 Protein denotes HOIP
T16723 1830-1839 Negative_regulation denotes deficient
T16724 1874-1881 Negative_regulation denotes reduces true
T16725 1882-1893 Binding denotes recruitment
T16726 1897-1902 Protein denotes cIAP1
T16727 1906-1910 Protein denotes CD40
T16728 1919-1925 Regulation denotes modify
T16729 1926-1930 Protein denotes HOIP true
T16730 1931-1942 Binding denotes recruitment
T16731 2537-2542 Protein denotes cIAP1
T16732 2544-2549 Protein denotes TRAF2
T16733 2551-2556 Protein denotes TRAF3
T16734 2562-2566 Protein denotes HOIP
T16735 2683-2687 Protein denotes CD40
T16736 2758-2762 Protein denotes HOIP
T16737 2763-2772 Negative_regulation denotes deficient
T16738 2861-2865 Protein denotes HOIP
T16739 2997-3001 Protein denotes CD40
T16740 3003-3008 Protein denotes TRAF2
T16741 3010-3015 Protein denotes TRAF3
T16742 3017-3022 Protein denotes cIAP1
T16743 3024-3028 Protein denotes HOIP
T16744 3030-3034 Protein denotes IKKα
T16745 3035-3036 Protein denotes β
T16746 3042-3046 Protein denotes IKKγ
T16747 3063-3067 Protein denotes HOIP
T16748 3068-3078 Gene_expression denotes expression
T16749 3083-3091 Positive_regulation denotes required
T16750 3133-3137 Protein denotes CD40
T16751 3296-3300 Protein denotes HOIP
T16752 3301-3310 Negative_regulation denotes deficient
T16753 3342-3346 Protein denotes HOIP
T16754 3347-3356 Regulation denotes dependent
T16755 3357-3368 Binding denotes recruitment
T16756 3372-3376 Protein denotes IKKγ
T16757 3380-3384 Protein denotes CD40
T16758 3402-3406 Protein denotes HOIP
T16759 3407-3416 Negative_regulation denotes deficient
T16760 3418-3422 Protein denotes HOIP
T16761 3541-3545 Protein denotes IKKγ
T16762 3570-3574 Protein denotes pMIP
T16763 3579-3583 Protein denotes IKKγ
T16764 3785-3789 Protein denotes IKKγ
T16765 3808-3813 Protein denotes TRAF2
T16766 4073-4078 Protein denotes TRAF3
T16767 4083-4087 Protein denotes HOIP
R4932 T6456 T6457 themeOf HOIP,deficient
R4933 T6459 T6460 themeOf HOIP,recruited
R4934 T6460 T6462 themeOf recruited,dependent
R4935 T6461 T6462 causeOf TRAF2,dependent
R4936 T6466 T6470 causeOf TRAF2,role
R4937 T6466 T6467 themeOf TRAF2,associated
R4938 T6467 T6470 causeOf associated,role
R4939 T6468 T6470 causeOf cIAP1,role
R4940 T6468 T6467 themeOf cIAP1,associated
R4941 T6469 T6467 themeOf cIAP2,associated
R4942 T6469 T6470 causeOf cIAP2,role
R4943 T6471 T6470 themeOf recruitment,role
R4944 T6472 T6471 themeOf HOIP,recruitment
R4945 T6473 T6471 themeOf TNFR1,recruitment
R4946 T6474 T6471 themeOf CD40,recruitment
R4947 T6475 T6478 themeOf association,altered
R4948 T6476 T6475 themeOf HOIP,association
R4949 T6477 T6475 themeOf CD40,association
R4950 T6479 T6478 causeOf inhibitor,altered
R4951 T6481 T6482 themeOf cIAP1,associated
R4952 T6482 T6480 themeOf associated,reduced
R4953 T6484 T6483 themeOf HOIP,decrease
R4954 T6489 T6490 themeOf CD40,associated
R4955 T6490 T6488 themeOf associated,alters
R4956 T6491 T6490 themeOf HOIP,associated
R4957 T6491 T6488 themeOf HOIP,alters
R4958 T6492 T6493 causeOf cIAP,influence
R4959 T6494 T6493 themeOf recruitment,influence
R4960 T6495 T6493 themeOf post-translational modification,influence
R4961 T6496 T6497 themeOf CD40,associated
R4962 T6496 T6495 themeOf CD40,post-translational modification
R4963 T6498 T6495 themeOf HOIP,post-translational modification
R4964 T6498 T6494 themeOf HOIP,recruitment
R4965 T6498 T6497 themeOf HOIP,associated
R4966 T6499 T6500 causeOf HOIP,responsible
R4967 T6501 T6500 themeOf recruitment,responsible
R4968 T6502 T6501 themeOf CD40,recruitment
R4969 T6503 T6504 themeOf HOIP,deficient
R4970 T6505 T6506 themeOf HOIP,reconstituted
R4971 T6513 T6521 themeOf TRAF2,association
R4972 T6514 T6521 themeOf TRAF3,association
R4973 T6515 T6521 themeOf cIAP1,association
R4974 T6517 T6518 themeOf HOIP,deficient
R4975 T6519 T6520 causeOf HOIP,required
R4976 T6519 T6521 themeOf HOIP,association
R4977 T6521 T6520 themeOf association,required
R4978 T6522 T6521 themeOf CD40,association
R4979 T6527 T6528 themeOf HOIP,deficient
R4980 T6533 T6534 themeOf HOIP,reconstituted
R4981 T6537 T6538 themeOf HOIP,expression
R4982 T6538 T6536 themeOf expression,absence
R4983 T6548 T6547 themeOf IKKγ,expressing
R4984 T6549 T6552 themeOf recruitment,requires
R4985 T6550 T6549 themeOf IKKγ,recruitment
R4986 T6551 T6549 themeOf CD40,recruitment
R4987 T6555 T6554 themeOf IKKγ,increased
R4988 T6556 T6554 themeOf CD40,increased
R4989 T6558 T6559 themeOf CD40,associated
R4990 T6559 T6557 themeOf associated,reduced
R4991 T6560 T6559 themeOf IKKγ,associated
R4992 T6560 T6557 themeOf IKKγ,reduced
R4993 T6561 T6562 themeOf CD40,associated
R4994 T6563 T6562 themeOf IKKγ,associated
R4995 T6565 T6566 causeOf HOIP,required
R4996 T6567 T6566 themeOf association,required
R4997 T6568 T6567 themeOf IKKγ,association
R4998 T6569 T6567 themeOf CD40,association
R4999 T6571 T6570 themeOf post-translational,coupled
R5000 T6573 T6571 themeOf IKKγ,post-translational
R13153 T16722 T16723 themeOf HOIP,deficient
R13154 T16725 T16724 themeOf recruitment,reduces
R13155 T16725 T16728 causeOf recruitment,modify
R13156 T16726 T16725 themeOf cIAP1,recruitment
R13157 T16727 T16725 themeOf CD40,recruitment
R13158 T16729 T16730 themeOf HOIP,recruitment
R13159 T16730 T16728 themeOf recruitment,modify
R13160 T16736 T16737 themeOf HOIP,deficient
R13161 T16747 T16748 themeOf HOIP,expression
R13162 T16748 T16749 causeOf expression,required
R13163 T16751 T16752 themeOf HOIP,deficient
R13164 T16753 T16754 causeOf HOIP,dependent
R13165 T16755 T16754 themeOf recruitment,dependent
R13166 T16756 T16755 themeOf IKKγ,recruitment
R13167 T16757 T16755 themeOf CD40,recruitment
R13168 T16758 T16759 themeOf HOIP,deficient