PMC:3148254 / 12486-15213 JSON TXT

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bionlp-st-ge-2016-reference

Id	Subject	Object	Predicate	Lexical cue	Negation
T5461	0-4	Protein	denotes	HOIP
T5462	14-18	Protein	denotes	CD40
T5463	93-97	Protein	denotes	HOIP
T5464	125-129	Protein	denotes	CD40
T5465	186-190	Protein	denotes	HOIP
T5466	219-223	Protein	denotes	CD40
T5467	311-316	Protein	denotes	CD154
T5468	318-329	Protein	denotes	CD40 ligand
T5469	331-340	Gene_expression	denotes	expressed
T5470	482-486	Protein	denotes	CD40
T5471	497-507	Binding	denotes	associated
T5472	508-513	Protein	denotes	CD154
T5473	848-859	Regulation	denotes	responsible
T5474	864-876	Negative_regulation	denotes	sequestering
T5475	877-891	Protein	denotes	NF-κB subunits
T5476	1068-1072	Protein	denotes	CD40
T5477	1073-1081	Positive_regulation	denotes	mediated
T5478	1073-1081	Positive_regulation	denotes	mediated
T5479	1082-1097	Phosphorylation	denotes	phosphorylation
T5480	1102-1113	Protein_catabolism	denotes	degradation
T5481	1117-1121	Protein	denotes	IκBα
T5482	1125-1129	Protein	denotes	HOIP
T5483	1130-1139	Negative_regulation	denotes	deficient
T5484	1163-1171	Negative_regulation	denotes	impaired
T5485	1163-1171	Negative_regulation	denotes	impaired
T5486	1318-1322	Protein	denotes	CD40
T5487	1323-1333	Binding	denotes	engagement
T5488	1344-1348	Protein	denotes	CD40
T5489	1376-1380	Protein	denotes	HOIP
T5490	1381-1390	Negative_regulation	denotes	deficient
T5491	1470-1474	Protein	denotes	CD40
T5492	1514-1518	Protein	denotes	HOIP
T5493	1519-1532	Positive_regulation	denotes	reconstituted
T5494	1642-1646	Protein	denotes	HOIP
T5495	1647-1657	Gene_expression	denotes	expression	true
T16162	1703-1707	Protein	denotes	CD40
T16163	1760-1764	Protein	denotes	HOIP
T16164	1765-1774	Negative_regulation	denotes	deficient
T16165	1782-1786	Protein	denotes	CD40
T16166	1823-1827	Protein	denotes	HOIP
T16167	1828-1837	Negative_regulation	denotes	deficient
T16168	1957-1961	Protein	denotes	HOIP
T16169	1962-1971	Negative_regulation	denotes	deficient
T16170	2023-2027	Protein	denotes	HOIP
T16171	2029-2033	Protein	denotes	HOIP
T16172	2039-2043	Protein	denotes	HOIP
T16173	2072-2077	Protein	denotes	CD154
T16174	2078-2088	Gene_expression	denotes	expressing
T16175	2190-2197	Negative_regulation	denotes	lacking
T16176	2198-2203	Protein	denotes	CD154
T16177	2311-2323	Protein	denotes	Phospho-IκBα
T16178	2325-2330	Protein	denotes	pIκBα
T16179	2398-2402	Protein	denotes	IκBα
T16180	2485-2489	Protein	denotes	IκBα
T16181	2703-2707	Protein	denotes	HOIP
T16182	2708-2717	Negative_regulation	denotes	deficient
R4184	T5467	T5469	themeOf	CD154,expressed
R4185	T5468	T5467	equivalentTo	CD40 ligand,CD154
R4186	T5472	T5471	themeOf	CD154,associated
R4187	T5474	T5473	themeOf	sequestering,responsible
R4188	T5475	T5474	themeOf	NF-κB subunits,sequestering
R4189	T5476	T5477	causeOf	CD40,mediated
R4190	T5476	T5478	causeOf	CD40,mediated
R4191	T5477	T5484	themeOf	mediated,impaired
R4192	T5478	T5485	themeOf	mediated,impaired
R4193	T5479	T5478	themeOf	phosphorylation,mediated
R4194	T5480	T5477	themeOf	degradation,mediated
R4195	T5481	T5480	themeOf	IκBα,degradation
R4196	T5481	T5479	themeOf	IκBα,phosphorylation
R4197	T5482	T5483	themeOf	HOIP,deficient
R4198	T5486	T5487	themeOf	CD40,engagement
R4199	T5489	T5490	themeOf	HOIP,deficient
R4200	T5492	T5493	themeOf	HOIP,reconstituted
R4201	T5494	T5495	themeOf	HOIP,expression
R12750	T16163	T16164	themeOf	HOIP,deficient
R12751	T16166	T16167	themeOf	HOIP,deficient
R12752	T16168	T16169	themeOf	HOIP,deficient
R12753	T16173	T16174	themeOf	CD154,expressing
R12754	T16176	T16175	themeOf	CD154,lacking
R12755	T16178	T16177	equivalentTo	pIκBα,Phospho-IκBα
R12756	T16181	T16182	themeOf	HOIP,deficient

bionlp-st-ge-2016-reference-tees

Id	Subject	Object	Predicate	Lexical cue
T6220	14-18	Protein	denotes	CD40
T6221	30-35	Protein	denotes	NF-κB
T6222	40-43	Protein	denotes	JNK
T6223	44-54	Positive_regulation	denotes	activation
T6224	5-13	Positive_regulation	denotes	mediates
T6225	19-29	Positive_regulation	denotes	stimulated
T6226	44-54	Positive_regulation	denotes	activation
T6227	125-129	Protein	denotes	CD40
T6228	219-223	Protein	denotes	CD40
T6229	311-316	Protein	denotes	CD154
T6230	318-322	Protein	denotes	CD40
T6231	401-406	Protein	denotes	NF-κB
T6232	411-414	Protein	denotes	JNK
T6233	331-340	Gene_expression	denotes	expressed
T6234	331-340	Gene_expression	denotes	expressed
T6235	383-393	Positive_regulation	denotes	activation
T6236	383-393	Positive_regulation	denotes	activation
T6237	508-513	Protein	denotes	CD154
T6238	669-673	Protein	denotes	CD40
T6239	712-717	Protein	denotes	NF-κB
T6240	767-779	Protein	denotes	IκB proteins
T6241	787-805	Protein	denotes	IκB kinase complex
T6242	807-810	Protein	denotes	IKK
T6243	684-694	Positive_regulation	denotes	Activation
T6244	748-763	Phosphorylation	denotes	phosphorylation
T6245	748-763	Phosphorylation	denotes	phosphorylation
T6246	748-763	Phosphorylation	denotes	phosphorylation
T6247	831-843	Protein	denotes	IκB proteins
T6248	877-891	Protein	denotes	NF-κB subunits
T6249	864-876	Positive_regulation	denotes	sequestering
T6250	933-936	Protein	denotes	IKK
T6251	953-956	Protein	denotes	IκB
T6252	1011-1016	Protein	denotes	NF-κB
T6253	910-925	Phosphorylation	denotes	Phosphorylation
T6254	945-952	Regulation	denotes	targets
T6255	989-1000	Protein_catabolism	denotes	degradation
T6256	1030-1037	Entity	denotes	nucleus
T6257	945-952	Regulation	denotes	targets
T6258	1068-1072	Protein	denotes	CD40
T6259	1117-1121	Protein	denotes	IκBα
T6260	1082-1097	Phosphorylation	denotes	phosphorylation
T6261	1102-1113	Protein_catabolism	denotes	degradation
T6262	1163-1171	Negative_regulation	denotes	impaired
T6263	1163-1171	Negative_regulation	denotes	impaired
T6264	1073-1081	Positive_regulation	denotes	mediated
T6265	1073-1081	Positive_regulation	denotes	mediated
T6266	1267-1298	Protein	denotes	stress-activated protein kinase
T6267	1299-1302	Protein	denotes	JNK
T6268	1318-1322	Protein	denotes	CD40
T6269	1249-1259	Positive_regulation	denotes	activation
T6270	1249-1259	Positive_regulation	denotes	activation
T6271	1323-1333	Binding	denotes	engagement
T6272	1344-1348	Protein	denotes	CD40
T6273	1358-1361	Protein	denotes	JNK
T6274	1465-1468	Protein	denotes	JNK
T6275	1362-1372	Positive_regulation	denotes	activation
T6276	1425-1440	Phosphorylation	denotes	phosphorylation
T6277	1349-1357	Positive_regulation	denotes	mediated
T6278	1362-1372	Positive_regulation	denotes	activation
T6279	1470-1474	Protein	denotes	CD40
T6280	1497-1502	Protein	denotes	NF-κB
T6281	1507-1510	Protein	denotes	JNK
T6282	1642-1646	Protein	denotes	HOIP
T6283	1647-1657	Gene_expression	denotes	expression
T6284	1631-1638	Negative_regulation	denotes	absence
T16631	1703-1707	Protein	denotes	CD40
T16632	1730-1735	Protein	denotes	NF-κB
T16633	1740-1743	Protein	denotes	JNK
T16634	1716-1726	Positive_regulation	denotes	activation
T16635	1708-1715	Positive_regulation	denotes	induced
T16636	1716-1726	Positive_regulation	denotes	activation
T16637	1782-1786	Protein	denotes	CD40
T16638	2072-2077	Protein	denotes	CD154
T16639	2078-2088	Gene_expression	denotes	expressing
T16640	2198-2203	Protein	denotes	CD154
T16641	2190-2197	Negative_regulation	denotes	lacking
T16642	2311-2323	Protein	denotes	Phospho-IκBα
T16643	2325-2330	Protein	denotes	pIκBα
T16644	2344-2347	Protein	denotes	JNK
T16645	2349-2353	Protein	denotes	pJNK
T16646	2398-2402	Protein	denotes	IκBα
T16647	2413-2416	Protein	denotes	JNK
T16648	2437-2440	Protein	denotes	JNK
T16649	2462-2465	Protein	denotes	p46
T16650	2470-2482	Protein	denotes	p54 isoforms
T16651	2452-2461	Binding	denotes	recognize
T16652	2452-2461	Binding	denotes	recognize
T16653	2485-2495	Protein	denotes	IκBα blots
T16654	2519-2524	Protein	denotes	actin
R4785	T6220	T6225	causeOf	CD40,stimulated
R4786	T6221	T6223	themeOf	NF-κB,activation
R4787	T6223	T6224	themeOf	activation,mediates
R4788	T6223	T6225	themeOf	activation,stimulated
R4789	T6225	T6226	themeOf	stimulated,activation
R4790	T6229	T6233	themeOf	CD154,expressed
R4791	T6230	T6234	themeOf	CD40,expressed
R4792	T6231	T6235	themeOf	NF-κB,activation
R4793	T6232	T6236	themeOf	JNK,activation
R4794	T6239	T6243	themeOf	NF-κB,Activation
R4795	T6240	T6244	themeOf	IκB proteins,phosphorylation
R4796	T6241	T6245	themeOf	IκB kinase complex,phosphorylation
R4797	T6242	T6246	themeOf	IKK,phosphorylation
R4798	T6247	T6249	causeOf	IκB proteins,sequestering
R4799	T6248	T6249	themeOf	NF-κB subunits,sequestering
R4800	T6250	T6253	themeOf	IKK,Phosphorylation
R4801	T6251	T6254	themeOf	IκB,targets
R4802	T6251	T6255	themeOf	IκB,degradation
R4803	T6253	T6254	causeOf	Phosphorylation,targets
R4804	T6253	T6257	causeOf	Phosphorylation,targets
R4805	T6255	T6257	themeOf	degradation,targets
R4806	T6258	T6264	causeOf	CD40,mediated
R4807	T6258	T6265	causeOf	CD40,mediated
R4808	T6259	T6260	themeOf	IκBα,phosphorylation
R4809	T6259	T6261	themeOf	IκBα,degradation
R4810	T6260	T6262	themeOf	phosphorylation,impaired
R4811	T6260	T6264	themeOf	phosphorylation,mediated
R4812	T6261	T6263	themeOf	degradation,impaired
R4813	T6261	T6265	themeOf	degradation,mediated
R4814	T6266	T6269	themeOf	stress-activated protein kinase,activation
R4815	T6267	T6270	themeOf	JNK,activation
R4816	T6268	T6271	themeOf	CD40,engagement
R4817	T6272	T6277	causeOf	CD40,mediated
R4818	T6273	T6275	themeOf	JNK,activation
R4819	T6274	T6276	themeOf	JNK,phosphorylation
R4820	T6275	T6277	themeOf	activation,mediated
R4821	T6277	T6278	themeOf	mediated,activation
R4822	T6282	T6283	themeOf	HOIP,expression
R4823	T6283	T6284	themeOf	expression,absence
R13124	T16631	T16635	causeOf	CD40,induced
R13125	T16632	T16634	themeOf	NF-κB,activation
R13126	T16634	T16635	themeOf	activation,induced
R13127	T16635	T16636	themeOf	induced,activation
R13128	T16638	T16639	themeOf	CD154,expressing
R13129	T16640	T16641	themeOf	CD154,lacking
R13130	T16649	T16651	themeOf	p46,recognize
R13131	T16650	T16652	themeOf	p54 isoforms,recognize

events-check-again

Id	Subject	Object	Predicate	Lexical cue	Negation
T6285	0-4	Protein	denotes	HOIP
T6286	14-18	Protein	denotes	CD40
T6287	93-97	Protein	denotes	HOIP
T6288	125-129	Protein	denotes	CD40
T6289	186-190	Protein	denotes	HOIP
T6290	219-223	Protein	denotes	CD40
T6291	311-316	Protein	denotes	CD154
T6292	318-329	Protein	denotes	CD40 ligand
T6293	331-340	Gene_expression	denotes	expressed
T6294	482-486	Protein	denotes	CD40
T6295	497-507	Binding	denotes	associated
T6296	508-513	Protein	denotes	CD154
T6297	848-859	Regulation	denotes	responsible
T6298	864-876	Negative_regulation	denotes	sequestering
T6299	877-891	Protein	denotes	NF-κB subunits
T6300	1068-1072	Protein	denotes	CD40
T6301	1073-1081	Positive_regulation	denotes	mediated
T6302	1073-1081	Positive_regulation	denotes	mediated
T6303	1082-1097	Phosphorylation	denotes	phosphorylation
T6304	1102-1113	Protein_catabolism	denotes	degradation
T6305	1117-1121	Protein	denotes	IκBα
T6306	1125-1129	Protein	denotes	HOIP
T6307	1130-1139	Negative_regulation	denotes	deficient
T6308	1163-1171	Negative_regulation	denotes	impaired
T6309	1163-1171	Negative_regulation	denotes	impaired
T6310	1318-1322	Protein	denotes	CD40
T6311	1323-1333	Binding	denotes	engagement
T6312	1344-1348	Protein	denotes	CD40
T6313	1376-1380	Protein	denotes	HOIP
T6314	1381-1390	Negative_regulation	denotes	deficient
T6315	1470-1474	Protein	denotes	CD40
T6316	1514-1518	Protein	denotes	HOIP
T6317	1519-1532	Positive_regulation	denotes	reconstituted
T6318	1642-1646	Protein	denotes	HOIP
T6319	1647-1657	Gene_expression	denotes	expression	true
T16655	1703-1707	Protein	denotes	CD40
T16656	1760-1764	Protein	denotes	HOIP
T16657	1765-1774	Negative_regulation	denotes	deficient
T16658	1782-1786	Protein	denotes	CD40
T16659	1823-1827	Protein	denotes	HOIP
T16660	1828-1837	Negative_regulation	denotes	deficient
T16661	1957-1961	Protein	denotes	HOIP
T16662	1962-1971	Negative_regulation	denotes	deficient
T16663	2023-2027	Protein	denotes	HOIP
T16664	2029-2033	Protein	denotes	HOIP
T16665	2039-2043	Protein	denotes	HOIP
T16666	2072-2077	Protein	denotes	CD154
T16667	2078-2088	Gene_expression	denotes	expressing
T16668	2190-2197	Negative_regulation	denotes	lacking
T16669	2198-2203	Protein	denotes	CD154
T16670	2311-2323	Protein	denotes	Phospho-IκBα
T16671	2325-2330	Protein	denotes	pIκBα
T16672	2398-2402	Protein	denotes	IκBα
T16673	2485-2489	Protein	denotes	IκBα
T16674	2703-2707	Protein	denotes	HOIP
T16675	2708-2717	Negative_regulation	denotes	deficient
R4824	T6291	T6293	themeOf	CD154,expressed
R4825	T6292	T6291	equivalentTo	CD40 ligand,CD154
R4826	T6296	T6295	themeOf	CD154,associated
R4827	T6298	T6297	themeOf	sequestering,responsible
R4828	T6299	T6298	themeOf	NF-κB subunits,sequestering
R4829	T6300	T6301	causeOf	CD40,mediated
R4830	T6300	T6302	causeOf	CD40,mediated
R4831	T6301	T6308	themeOf	mediated,impaired
R4832	T6302	T6309	themeOf	mediated,impaired
R4833	T6303	T6302	themeOf	phosphorylation,mediated
R4834	T6304	T6301	themeOf	degradation,mediated
R4835	T6305	T6304	themeOf	IκBα,degradation
R4836	T6305	T6303	themeOf	IκBα,phosphorylation
R4837	T6306	T6307	themeOf	HOIP,deficient
R4838	T6310	T6311	themeOf	CD40,engagement
R4839	T6313	T6314	themeOf	HOIP,deficient
R4840	T6316	T6317	themeOf	HOIP,reconstituted
R4841	T6318	T6319	themeOf	HOIP,expression
R13132	T16656	T16657	themeOf	HOIP,deficient
R13133	T16659	T16660	themeOf	HOIP,deficient
R13134	T16661	T16662	themeOf	HOIP,deficient
R13135	T16666	T16667	themeOf	CD154,expressing
R13136	T16669	T16668	themeOf	CD154,lacking
R13137	T16671	T16670	equivalentTo	pIκBα,Phospho-IκBα
R13138	T16674	T16675	themeOf	HOIP,deficient

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T5789	0-4	NN	denotes	HOIP
T5790	5-13	VB	denotes	mediates
T5791	14-29	JJ	denotes	CD40-stimulated
T5792	30-35	NN	denotes	NF-κB
T5793	36-39	CC	denotes	and
T5794	40-43	NN	denotes	JNK
T5795	44-54	NN	denotes	activation
T5796	55-58	DT	denotes	The
T5797	59-66	NN	denotes	results
T5798	67-76	VB	denotes	described
T5799	77-82	IN	denotes	above
T5800	83-87	VB	denotes	show
T5801	88-92	IN	denotes	that
T5802	93-97	NN	denotes	HOIP
T5803	98-103	VB	denotes	plays
T5804	104-106	DT	denotes	an
T5805	107-116	JJ	denotes	important
T5806	117-121	NN	denotes	role
T5807	122-124	IN	denotes	in
T5808	125-138	JJ	denotes	CD40-mediated
T5809	139-147	NN	denotes	effector
T5810	148-157	NN	denotes	functions
T5811	158-160	IN	denotes	of
T5812	161-162	NN	denotes	B
T5813	163-168	NN	denotes	cells
T5814	170-172	PRP	denotes	It
T5815	173-180	VB	denotes	follows
T5816	181-185	IN	denotes	that
T5817	186-190	NN	denotes	HOIP
T5818	191-193	VB	denotes	is
T5819	194-200	RB	denotes	likely
T5820	201-202	DT	denotes	a
T5821	203-206	JJ	denotes	key
T5822	207-215	NN	denotes	mediator
T5823	216-218	IN	denotes	of
T5824	219-223	NN	denotes	CD40
T5825	224-233	NN	denotes	signaling
T5826	235-237	TO	denotes	To
T5827	238-242	VB	denotes	test
T5828	243-247	DT	denotes	this
T5829	248-258	NN	denotes	hypothesis
T5830	258-259	-COMMA-	denotes	,
T5831	260-262	PRP	denotes	we
T5832	263-273	VB	denotes	stimulated
T5833	274-280	NN	denotes	A20.2J
T5834	281-284	CC	denotes	and
T5835	285-299	JJ	denotes	HOIP-deficient
T5836	300-305	NN	denotes	cells
T5837	306-310	IN	denotes	with
T5838	311-316	NN	denotes	CD154
T5839	317-318	-LRB-	denotes	(
T5840	318-322	NN	denotes	CD40
T5841	323-329	NN	denotes	ligand
T5842	329-330	-RRB-	denotes	)
T5843	331-340	VB	denotes	expressed
T5844	341-343	IN	denotes	by
T5845	344-347	NN	denotes	HI5
T5846	348-354	NN	denotes	insect
T5847	355-360	NN	denotes	cells
T5848	361-362	-LRB-	denotes	[
T5849	362-363	CD	denotes	7
T5850	363-364	-RRB-	denotes	]
T5851	364-365	-COMMA-	denotes	,
T5852	366-367	-LRB-	denotes	[
T5853	367-368	CD	denotes	8
T5854	368-369	-RRB-	denotes	]
T5855	370-373	CC	denotes	and
T5856	374-382	VB	denotes	measured
T5857	383-393	NN	denotes	activation
T5858	394-396	IN	denotes	of
T5859	397-400	DT	denotes	the
T5860	401-406	NN	denotes	NF-κB
T5861	407-410	CC	denotes	and
T5862	411-414	NN	denotes	JNK
T5863	415-423	NN	denotes	pathways
T5864	423-424	-COMMA-	denotes	,
T5865	425-428	CD	denotes	two
T5866	429-431	IN	denotes	of
T5867	432-435	DT	denotes	the
T5868	436-441	JJ	denotes	major
T5869	442-457	JJ	denotes	transcriptional
T5870	458-468	NN	denotes	regulators
T5871	469-478	VB	denotes	activated
T5872	479-481	IN	denotes	by
T5873	482-486	NN	denotes	CD40
T5874	487-488	-LRB-	denotes	[
T5875	488-489	CD	denotes	4
T5876	489-490	-RRB-	denotes	]
T5877	492-507	JJ	denotes	Cell-associated
T5878	508-513	NN	denotes	CD154
T5879	514-517	VB	denotes	was
T5880	518-522	VB	denotes	used
T5881	523-525	IN	denotes	as
T5882	526-529	DT	denotes	the
T5883	530-538	NN	denotes	stimulus
T5884	539-541	IN	denotes	in
T5885	542-547	DT	denotes	these
T5886	548-559	NN	denotes	experiments
T5887	560-562	IN	denotes	as
T5888	563-565	PRP	denotes	it
T5889	566-575	RB	denotes	typically
T5890	576-584	VB	denotes	provides
T5891	585-589	RB	denotes	more
T5892	590-596	JJ	denotes	robust
T5893	596-597	-COMMA-	denotes	,
T5894	598-601	CC	denotes	and
T5895	602-611	RB	denotes	therefore
T5896	612-616	RB	denotes	more
T5897	617-624	RB	denotes	readily
T5898	625-633	VB	denotes	detected
T5899	633-634	-COMMA-	denotes	,
T5900	635-645	NN	denotes	activation
T5901	646-653	NN	denotes	signals
T5902	654-658	IN	denotes	than
T5903	659-663	VB	denotes	does
T5904	664-673	JJ	denotes	anti-CD40
T5905	674-682	NN	denotes	antibody
T5906	684-694	NN	denotes	Activation
T5907	695-697	IN	denotes	of
T5908	698-701	DT	denotes	the
T5909	702-711	JJ	denotes	canonical
T5910	712-717	NN	denotes	NF-κB
T5911	718-725	NN	denotes	pathway
T5912	726-728	VB	denotes	is
T5913	729-738	VB	denotes	initiated
T5914	739-743	IN	denotes	with
T5915	744-747	DT	denotes	the
T5916	748-763	NN	denotes	phosphorylation
T5917	764-766	IN	denotes	of
T5918	767-770	NN	denotes	IκB
T5919	771-779	NN	denotes	proteins
T5920	780-782	IN	denotes	by
T5921	783-786	DT	denotes	the
T5922	787-790	NN	denotes	IκB
T5923	791-797	NN	denotes	kinase
T5924	798-805	NN	denotes	complex
T5925	806-807	-LRB-	denotes	(
T5926	807-810	NN	denotes	IKK
T5927	810-811	-RRB-	denotes	)
T5928	813-815	IN	denotes	In
T5929	816-823	VB	denotes	resting
T5930	824-829	NN	denotes	cells
T5931	829-830	-COMMA-	denotes	,
T5932	831-834	NN	denotes	IκB
T5933	835-843	NN	denotes	proteins
T5934	844-847	VB	denotes	are
T5935	848-859	JJ	denotes	responsible
T5936	860-863	IN	denotes	for
T5937	864-876	VB	denotes	sequestering
T5938	877-882	NN	denotes	NF-κB
T5939	883-891	NN	denotes	subunits
T5940	892-894	IN	denotes	in
T5941	895-898	DT	denotes	the
T5942	899-908	NN	denotes	cytoplasm
T5943	910-925	NN	denotes	Phosphorylation
T5944	926-928	IN	denotes	by
T5945	929-932	DT	denotes	the
T5946	933-936	NN	denotes	IKK
T5947	937-944	NN	denotes	complex
T5948	945-952	VB	denotes	targets
T5949	953-956	NN	denotes	IκB
T5950	957-965	NN	denotes	proteins
T5951	966-969	IN	denotes	for
T5952	970-984	NN	denotes	ubiquitination
T5953	985-988	CC	denotes	and
T5954	989-1000	NN	denotes	degradation
T5955	1000-1001	-COMMA-	denotes	,
T5956	1002-1010	VB	denotes	allowing
T5957	1011-1016	NN	denotes	NF-κB
T5958	1017-1019	TO	denotes	to
T5959	1020-1025	VB	denotes	enter
T5960	1026-1029	DT	denotes	the
T5961	1030-1037	NN	denotes	nucleus
T5962	1038-1041	CC	denotes	and
T5963	1042-1050	VB	denotes	activate
T5964	1051-1055	NN	denotes	gene
T5965	1056-1066	NN	denotes	expression
T5966	1068-1081	JJ	denotes	CD40-mediated
T5967	1082-1097	NN	denotes	phosphorylation
T5968	1098-1101	CC	denotes	and
T5969	1102-1113	NN	denotes	degradation
T5970	1114-1116	IN	denotes	of
T5971	1117-1121	NN	denotes	IκBα
T5972	1122-1124	IN	denotes	in
T5973	1125-1139	JJ	denotes	HOIP-deficient
T5974	1140-1145	NN	denotes	cells
T5975	1146-1149	VB	denotes	was
T5976	1150-1162	RB	denotes	dramatically
T5977	1163-1171	JJ	denotes	impaired
T5978	1172-1180	JJ	denotes	relative
T5979	1181-1183	TO	denotes	to
T5980	1184-1188	DT	denotes	that
T5981	1189-1197	VB	denotes	observed
T5982	1198-1200	IN	denotes	in
T5983	1201-1209	JJ	denotes	parental
T5984	1210-1216	NN	denotes	A20.2J
T5985	1217-1222	NN	denotes	cells
T5986	1223-1224	-LRB-	denotes	(
T5987	1224-1228	NN	denotes	Fig.
T5988	1229-1230	CD	denotes	4
T5989	1230-1231	-RRB-	denotes	)
T5990	1233-1235	PRP	denotes	We
T5991	1236-1240	RB	denotes	also
T5992	1241-1248	VB	denotes	assayed
T5993	1249-1259	NN	denotes	activation
T5994	1260-1262	IN	denotes	of
T5995	1263-1266	DT	denotes	the
T5996	1267-1283	JJ	denotes	stress-activated
T5997	1284-1291	NN	denotes	protein
T5998	1292-1298	NN	denotes	kinase
T5999	1299-1302	NN	denotes	JNK
T6000	1303-1305	IN	denotes	in
T6001	1306-1314	NN	denotes	response
T6002	1315-1317	TO	denotes	to
T6003	1318-1322	NN	denotes	CD40
T6004	1323-1333	NN	denotes	engagement
T6005	1334-1335	-LRB-	denotes	(
T6006	1335-1339	NN	denotes	Fig.
T6007	1340-1341	CD	denotes	4
T6008	1341-1342	-RRB-	denotes	)
T6009	1344-1357	JJ	denotes	CD40-mediated
T6010	1358-1361	NN	denotes	JNK
T6011	1362-1372	NN	denotes	activation
T6012	1373-1375	IN	denotes	in
T6013	1376-1390	JJ	denotes	HOIP-deficient
T6014	1391-1396	NN	denotes	cells
T6015	1397-1400	VB	denotes	was
T6016	1401-1409	VB	denotes	impaired
T6017	1410-1412	IN	denotes	as
T6018	1413-1421	VB	denotes	measured
T6019	1422-1424	IN	denotes	by
T6020	1425-1440	NN	denotes	phosphorylation
T6021	1441-1443	IN	denotes	of
T6022	1444-1450	NN	denotes	Thr183
T6023	1451-1454	CC	denotes	and
T6024	1455-1461	NN	denotes	Tyr185
T6025	1462-1464	IN	denotes	in
T6026	1465-1468	NN	denotes	JNK
T6027	1470-1482	JJ	denotes	CD40-induced
T6028	1483-1493	NN	denotes	activation
T6029	1494-1496	IN	denotes	of
T6030	1497-1502	NN	denotes	NF-κB
T6031	1503-1506	CC	denotes	and
T6032	1507-1510	NN	denotes	JNK
T6033	1511-1513	IN	denotes	in
T6034	1514-1532	JJ	denotes	HOIP-reconstituted
T6035	1533-1538	NN	denotes	cells
T6036	1539-1542	VB	denotes	was
T6037	1543-1549	JJ	denotes	normal
T6038	1549-1550	-COMMA-	denotes	,
T6039	1551-1564	VB	denotes	demonstrating
T6040	1565-1569	IN	denotes	that
T6041	1570-1573	DT	denotes	the
T6042	1574-1581	NN	denotes	defects
T6043	1582-1590	VB	denotes	observed
T6044	1591-1593	IN	denotes	in
T6045	1594-1608	JJ	denotes	gene-deficient
T6046	1609-1614	NN	denotes	cells
T6047	1615-1619	VB	denotes	were
T6048	1620-1623	JJ	denotes	due
T6049	1624-1626	TO	denotes	to
T6050	1627-1630	DT	denotes	the
T6051	1631-1638	NN	denotes	absence
T6052	1639-1641	IN	denotes	of
T6053	1642-1646	NN	denotes	HOIP
T6054	1647-1657	NN	denotes	expression
T7483	937-944	NN	denotes	complex
T16374	1703-1715	JJ	denotes	CD40-induced
T16375	1716-1726	NN	denotes	activation
T16376	1727-1729	IN	denotes	of
T16377	1730-1735	NN	denotes	NF-κB
T16378	1736-1739	CC	denotes	and
T16379	1740-1743	NN	denotes	JNK
T16380	1744-1746	VB	denotes	is
T16381	1747-1756	JJ	denotes	defective
T16382	1757-1759	IN	denotes	in
T16383	1760-1774	JJ	denotes	HOIP-deficient
T16384	1775-1780	NN	denotes	cells
T16385	1782-1795	JJ	denotes	CD40-mediated
T16386	1796-1805	NN	denotes	signaling
T16387	1806-1809	VB	denotes	was
T16388	1810-1819	JJ	denotes	defective
T16389	1820-1822	IN	denotes	in
T16390	1823-1837	JJ	denotes	HOIP-deficient
T16391	1838-1843	NN	denotes	cells
T16392	1844-1845	-LRB-	denotes	(
T16393	1845-1852	JJ	denotes	HOIP-/-
T16394	1853-1854	SYM	denotes	+
T16395	1855-1859	NN	denotes	pMIP
T16396	1859-1860	-RRB-	denotes	)
T16397	1860-1861	-COMMA-	denotes	,
T16398	1862-1865	CC	denotes	but
T16399	1866-1872	JJ	denotes	intact
T16400	1873-1875	IN	denotes	in
T16401	1876-1884	JJ	denotes	parental
T16402	1885-1890	NN	denotes	cells
T16403	1891-1901	VB	denotes	transduced
T16404	1902-1906	IN	denotes	with
T16405	1907-1909	DT	denotes	an
T16406	1910-1915	JJ	denotes	empty
T16407	1916-1926	JJ	denotes	retroviral
T16408	1927-1933	NN	denotes	vector
T16409	1934-1935	-LRB-	denotes	(
T16410	1935-1941	NN	denotes	A20.2J
T16411	1942-1943	SYM	denotes	+
T16412	1944-1948	NN	denotes	pMIP
T16413	1948-1949	-RRB-	denotes	)
T16414	1950-1953	CC	denotes	and
T16415	1954-1956	IN	denotes	in
T16416	1957-1971	JJ	denotes	HOIP-deficient
T16417	1972-1977	NN	denotes	cells
T16418	1978-1988	VB	denotes	transduced
T16419	1989-1993	IN	denotes	with
T16420	1994-1995	DT	denotes	a
T16421	1996-2006	JJ	denotes	retroviral
T16422	2007-2013	NN	denotes	vector
T16423	2014-2022	VB	denotes	encoding
T16424	2023-2027	NN	denotes	HOIP
T16425	2028-2029	-LRB-	denotes	(
T16426	2029-2036	JJ	denotes	HOIP-/-
T16427	2037-2038	SYM	denotes	+
T16428	2039-2043	NN	denotes	HOIP
T16429	2043-2044	-RRB-	denotes	)
T16430	2046-2051	NN	denotes	Cells
T16431	2052-2056	VB	denotes	were
T16432	2057-2066	VB	denotes	activated
T16433	2067-2071	IN	denotes	with
T16434	2072-2088	JJ	denotes	CD154-expressing
T16435	2089-2095	NN	denotes	insect
T16436	2096-2101	NN	denotes	cells
T16437	2102-2105	IN	denotes	for
T16438	2106-2109	DT	denotes	the
T16439	2110-2115	NN	denotes	times
T16440	2116-2125	VB	denotes	indicated
T16441	2127-2129	IN	denotes	As
T16442	2130-2131	DT	denotes	a
T16443	2132-2140	JJ	denotes	negative
T16444	2141-2148	NN	denotes	control
T16445	2148-2149	-COMMA-	denotes	,
T16446	2150-2155	NN	denotes	cells
T16447	2156-2160	VB	denotes	were
T16448	2161-2171	VB	denotes	stimulated
T16449	2172-2176	IN	denotes	with
T16450	2177-2183	NN	denotes	insect
T16451	2184-2189	NN	denotes	cells
T16452	2190-2197	VB	denotes	lacking
T16453	2198-2203	NN	denotes	CD154
T16454	2204-2205	-LRB-	denotes	(
T16455	2205-2206	CD	denotes	5
T16456	2207-2213	JJ	denotes	minute
T16457	2214-2218	NN	denotes	time
T16458	2219-2224	NN	denotes	point
T16459	2225-2229	RB	denotes	only
T16460	2229-2230	-RRB-	denotes	)
T16461	2232-2239	JJ	denotes	Western
T16462	2240-2245	NN	denotes	blots
T16463	2246-2248	IN	denotes	of
T16464	2249-2259	JJ	denotes	whole-cell
T16465	2260-2267	NN	denotes	lysates
T16466	2268-2272	VB	denotes	were
T16467	2273-2279	VB	denotes	probed
T16468	2280-2284	IN	denotes	with
T16469	2285-2288	DT	denotes	the
T16470	2289-2298	JJ	denotes	indicated
T16471	2299-2309	NN	denotes	antibodies
T16472	2311-2323	NN	denotes	Phospho-IκBα
T16473	2324-2325	-LRB-	denotes	(
T16474	2325-2330	NN	denotes	pIκBα
T16475	2330-2331	-RRB-	denotes	)
T16476	2332-2335	CC	denotes	and
T16477	2336-2347	NN	denotes	phospho-JNK
T16478	2348-2349	-LRB-	denotes	(
T16479	2349-2353	NN	denotes	pJNK
T16480	2353-2354	-RRB-	denotes	)
T16481	2355-2360	NN	denotes	blots
T16482	2361-2365	VB	denotes	were
T16483	2366-2374	VB	denotes	stripped
T16484	2375-2378	CC	denotes	and
T16485	2379-2387	VB	denotes	reprobed
T16486	2388-2391	IN	denotes	for
T16487	2392-2397	JJ	denotes	total
T16488	2398-2402	NN	denotes	IκBα
T16489	2403-2406	CC	denotes	and
T16490	2407-2412	JJ	denotes	total
T16491	2413-2416	NN	denotes	JNK
T16492	2416-2417	-COMMA-	denotes	,
T16493	2418-2430	RB	denotes	respectively
T16494	2431-2432	-LRB-	denotes	(
T16495	2432-2440	JJ	denotes	anti-JNK
T16496	2441-2451	NN	denotes	antibodies
T16497	2452-2461	VB	denotes	recognize
T16498	2462-2465	NN	denotes	p46
T16499	2466-2469	CC	denotes	and
T16500	2470-2473	NN	denotes	p54
T16501	2474-2482	NN	denotes	isoforms
T16502	2482-2483	-RRB-	denotes	)
T16503	2485-2489	NN	denotes	IκBα
T16504	2490-2495	NN	denotes	blots
T16505	2496-2500	VB	denotes	were
T16506	2501-2505	RB	denotes	also
T16507	2506-2514	VB	denotes	reprobed
T16508	2515-2518	IN	denotes	for
T16509	2519-2524	NN	denotes	actin
T16510	2525-2527	TO	denotes	to
T16511	2528-2539	VB	denotes	demonstrate
T16512	2540-2545	JJ	denotes	equal
T16513	2546-2550	NN	denotes	lane
T16514	2551-2558	NN	denotes	loading
T16515	2560-2569	JJ	denotes	Molecular
T16516	2570-2577	NN	denotes	weights
T16517	2578-2581	VB	denotes	are
T16518	2582-2591	VB	denotes	indicated
T16519	2592-2594	IN	denotes	at
T16520	2595-2600	NN	denotes	right
T16521	2602-2609	JJ	denotes	Similar
T16522	2610-2617	NN	denotes	results
T16523	2618-2622	VB	denotes	were
T16524	2623-2631	VB	denotes	obtained
T16525	2632-2634	IN	denotes	in
T16526	2635-2636	DT	denotes	a
T16527	2637-2643	JJ	denotes	second
T16528	2644-2654	NN	denotes	experiment
T16529	2655-2658	CC	denotes	and
T16530	2659-2661	IN	denotes	in
T16531	2662-2665	CD	denotes	two
T16532	2666-2676	JJ	denotes	additional
T16533	2677-2688	NN	denotes	experiments
T16534	2689-2693	IN	denotes	with
T16535	2694-2695	DT	denotes	a
T16536	2696-2702	JJ	denotes	second
T16537	2703-2717	JJ	denotes	HOIP-deficient
T16538	2718-2723	NN	denotes	clone
R4483	T5789	T5790	arg1Of	HOIP,mediates
R4484	T5792	T5791	arg1Of	NF-κB,CD40-stimulated
R4485	T5792	T5793	arg1Of	NF-κB,and
R4486	T5793	T5790	arg2Of	and,mediates
R4487	T5795	T5793	arg2Of	activation,and
R4488	T5795	T5794	arg1Of	activation,JNK
R4489	T5797	T5796	arg1Of	results,The
R4490	T5797	T5798	arg2Of	results,described
R4491	T5797	T5800	arg1Of	results,show
R4492	T5798	T5799	arg1Of	described,above
R4493	T5802	T5803	arg1Of	HOIP,plays
R4494	T5803	T5800	arg2Of	plays,show
R4495	T5803	T5801	arg1Of	plays,that
R4496	T5803	T5807	arg1Of	plays,in
R4497	T5806	T5803	arg2Of	role,plays
R4498	T5806	T5804	arg1Of	role,an
R4499	T5806	T5805	arg1Of	role,important
R4500	T5810	T5807	arg2Of	functions,in
R4501	T5810	T5808	arg1Of	functions,CD40-mediated
R4502	T5810	T5809	arg1Of	functions,effector
R4503	T5810	T5811	arg1Of	functions,of
R4504	T5813	T5811	arg2Of	cells,of
R4505	T5813	T5812	arg1Of	cells,B
R4506	T5817	T5818	arg1Of	HOIP,is
R4507	T5818	T5814	arg1Of	is,It
R4508	T5818	T5815	arg1Of	is,follows
R4509	T5818	T5816	arg1Of	is,that
R4510	T5818	T5819	arg1Of	is,likely
R4511	T5822	T5818	arg2Of	mediator,is
R4512	T5822	T5820	arg1Of	mediator,a
R4513	T5822	T5821	arg1Of	mediator,key
R4514	T5822	T5823	arg1Of	mediator,of
R4515	T5825	T5823	arg2Of	signaling,of
R4516	T5825	T5824	arg1Of	signaling,CD40
R4517	T5827	T5826	arg1Of	test,To
R4518	T5829	T5827	arg2Of	hypothesis,test
R4519	T5829	T5828	arg1Of	hypothesis,this
R4520	T5831	T5827	arg1Of	we,test
R4521	T5831	T5832	arg1Of	we,stimulated
R4522	T5832	T5826	modOf	stimulated,To
R4523	T5832	T5830	arg1Of	stimulated,","
R4524	T5833	T5834	arg1Of	A20.2J,and
R4525	T5834	T5832	arg2Of	and,stimulated
R4526	T5834	T5837	arg1Of	and,with
R4527	T5836	T5834	arg2Of	cells,and
R4528	T5836	T5835	arg1Of	cells,HOIP-deficient
R4529	T5838	T5839	arg1Of	CD154,(
R4530	T5838	T5843	arg2Of	CD154,expressed
R4531	T5838	T5855	arg1Of	CD154,and
R4532	T5841	T5839	arg2Of	ligand,(
R4533	T5841	T5840	arg1Of	ligand,CD40
R4534	T5842	T5839	arg3Of	),(
R4535	T5843	T5851	arg1Of	expressed,","
R4536	T5843	T5852	arg1Of	expressed,[
R4537	T5847	T5843	arg1Of	cells,expressed
R4538	T5847	T5844	arg2Of	cells,by
R4539	T5847	T5845	arg1Of	cells,HI5
R4540	T5847	T5846	arg1Of	cells,insect
R4541	T5847	T5848	arg1Of	cells,[
R4542	T5849	T5848	arg2Of	7,[
R4543	T5850	T5848	arg3Of	],[
R4544	T5853	T5852	arg2Of	8,[
R4545	T5854	T5852	arg3Of	],[
R4546	T5855	T5837	arg2Of	and,with
R4547	T5857	T5855	arg2Of	activation,and
R4548	T5857	T5856	arg2Of	activation,measured
R4549	T5857	T5858	arg1Of	activation,of
R4550	T5860	T5861	arg1Of	NF-κB,and
R4551	T5862	T5861	arg2Of	JNK,and
R4552	T5863	T5858	arg2Of	pathways,of
R4553	T5863	T5859	arg1Of	pathways,the
R4554	T5863	T5860	arg1Of	pathways,NF-κB
R4555	T5863	T5862	arg1Of	pathways,JNK
R4556	T5863	T5864	arg1Of	pathways,","
R4557	T5865	T5864	arg2Of	two,","
R4558	T5865	T5866	arg1Of	two,of
R4559	T5870	T5866	arg2Of	regulators,of
R4560	T5870	T5867	arg1Of	regulators,the
R4561	T5870	T5868	arg1Of	regulators,major
R4562	T5870	T5869	arg1Of	regulators,transcriptional
R4563	T5870	T5871	arg2Of	regulators,activated
R4564	T5871	T5874	arg1Of	activated,[
R4565	T5873	T5871	arg1Of	CD40,activated
R4566	T5873	T5872	arg2Of	CD40,by
R4567	T5875	T5874	arg2Of	4,[
R4568	T5876	T5874	arg3Of	],[
R4569	T5878	T5877	arg1Of	CD154,Cell-associated
R4570	T5878	T5879	arg1Of	CD154,was
R4571	T5878	T5880	arg2Of	CD154,used
R4572	T5880	T5879	arg2Of	used,was
R4573	T5880	T5881	arg1Of	used,as
R4574	T5883	T5881	arg2Of	stimulus,as
R4575	T5883	T5882	arg1Of	stimulus,the
R4576	T5883	T5884	arg1Of	stimulus,in
R4577	T5886	T5884	arg2Of	experiments,in
R4578	T5886	T5885	arg1Of	experiments,these
R4579	T5886	T5887	arg1Of	experiments,as
R4580	T5888	T5890	arg1Of	it,provides
R4581	T5890	T5887	arg2Of	provides,as
R4582	T5890	T5889	arg1Of	provides,typically
R4583	T5892	T5891	arg1Of	robust,more
R4584	T5892	T5894	arg1Of	robust,and
R4585	T5894	T5893	arg1Of	and,","
R4586	T5896	T5894	arg2Of	more,and
R4587	T5896	T5895	arg1Of	more,therefore
R4588	T5898	T5897	arg1Of	detected,readily
R4589	T5901	T5890	arg2Of	signals,provides
R4590	T5901	T5892	arg1Of	signals,robust
R4591	T5901	T5896	arg1Of	signals,more
R4592	T5901	T5898	arg2Of	signals,detected
R4593	T5901	T5899	arg1Of	signals,","
R4594	T5901	T5900	arg1Of	signals,activation
R4595	T5901	T5902	arg1Of	signals,than
R4596	T5903	T5902	arg2Of	does,than
R4597	T5905	T5903	arg1Of	antibody,does
R4598	T5905	T5904	arg1Of	antibody,anti-CD40
R4599	T5906	T5907	arg1Of	Activation,of
R4600	T5906	T5912	arg1Of	Activation,is
R4601	T5906	T5913	arg2Of	Activation,initiated
R4602	T5911	T5907	arg2Of	pathway,of
R4603	T5911	T5908	arg1Of	pathway,the
R4604	T5911	T5909	arg1Of	pathway,canonical
R4605	T5911	T5910	arg1Of	pathway,NF-κB
R4606	T5913	T5912	arg2Of	initiated,is
R4607	T5913	T5914	arg1Of	initiated,with
R4608	T5916	T5914	arg2Of	phosphorylation,with
R4609	T5916	T5915	arg1Of	phosphorylation,the
R4610	T5916	T5917	arg1Of	phosphorylation,of
R4611	T5916	T5920	arg1Of	phosphorylation,by
R4612	T5919	T5917	arg2Of	proteins,of
R4613	T5919	T5918	arg1Of	proteins,IκB
R4614	T5924	T5920	arg2Of	complex,by
R4615	T5924	T5921	arg1Of	complex,the
R4616	T5924	T5922	arg1Of	complex,IκB
R4617	T5924	T5923	arg1Of	complex,kinase
R4618	T5924	T5925	arg1Of	complex,(
R4619	T5926	T5925	arg2Of	IKK,(
R4620	T5927	T5925	arg3Of	),(
R4621	T5930	T5928	arg2Of	cells,In
R4622	T5930	T5929	arg1Of	cells,resting
R4623	T5933	T5932	arg1Of	proteins,IκB
R4624	T5933	T5934	arg1Of	proteins,are
R4625	T5933	T5935	arg1Of	proteins,responsible
R4626	T5934	T5928	arg1Of	are,In
R4627	T5934	T5931	arg1Of	are,","
R4628	T5935	T5934	arg2Of	responsible,are
R4629	T5935	T5936	arg1Of	responsible,for
R4630	T5937	T5936	arg2Of	sequestering,for
R4631	T5937	T5940	arg1Of	sequestering,in
R4632	T5939	T5937	arg2Of	subunits,sequestering
R4633	T5939	T5938	arg1Of	subunits,NF-κB
R4634	T5942	T5940	arg2Of	cytoplasm,in
R4635	T5942	T5941	arg1Of	cytoplasm,the
R4636	T5943	T5944	arg1Of	Phosphorylation,by
R4637	T5943	T5948	arg1Of	Phosphorylation,targets
R4638	T5947	T5944	arg2Of	complex,by
R4639	T5947	T5945	arg1Of	complex,the
R4640	T5947	T5946	arg1Of	complex,IKK
R4641	T5948	T5955	arg1Of	targets,","
R4642	T5948	T5956	modOf	targets,allowing
R4643	T5950	T5948	arg2Of	proteins,targets
R4644	T5950	T5949	arg1Of	proteins,IκB
R4645	T5950	T5951	arg1Of	proteins,for
R4646	T5952	T5953	arg1Of	ubiquitination,and
R4647	T5953	T5951	arg2Of	and,for
R4648	T5954	T5953	arg2Of	degradation,and
R4649	T5957	T5956	arg2Of	NF-κB,allowing
R4650	T5957	T5959	arg1Of	NF-κB,enter
R4651	T5957	T5963	arg1Of	NF-κB,activate
R4652	T5959	T5962	arg1Of	enter,and
R4653	T5961	T5959	arg2Of	nucleus,enter
R4654	T5961	T5960	arg1Of	nucleus,the
R4655	T5962	T5956	arg3Of	and,allowing
R4656	T5962	T5958	arg1Of	and,to
R4657	T5963	T5962	arg2Of	activate,and
R4658	T5965	T5963	arg2Of	expression,activate
R4659	T5965	T5964	arg1Of	expression,gene
R4660	T5967	T5966	arg1Of	phosphorylation,CD40-mediated
R4661	T5967	T5968	arg1Of	phosphorylation,and
R4662	T5968	T5972	arg1Of	and,in
R4663	T5968	T5975	arg1Of	and,was
R4664	T5968	T5977	arg1Of	and,impaired
R4665	T5969	T5968	arg2Of	degradation,and
R4666	T5969	T5970	arg1Of	degradation,of
R4667	T5971	T5970	arg2Of	IκBα,of
R4668	T5974	T5972	arg2Of	cells,in
R4669	T5974	T5973	arg1Of	cells,HOIP-deficient
R4670	T5977	T5975	arg2Of	impaired,was
R4671	T5977	T5976	arg1Of	impaired,dramatically
R4672	T5977	T5979	arg1Of	impaired,to
R4673	T5979	T5978	arg1Of	to,relative
R4674	T5980	T5979	arg2Of	that,to
R4675	T5980	T5981	arg2Of	that,observed
R4676	T5981	T5982	arg1Of	observed,in
R4677	T5985	T5982	arg2Of	cells,in
R4678	T5985	T5983	arg1Of	cells,parental
R4679	T5985	T5984	arg1Of	cells,A20.2J
R4680	T5985	T5986	arg1Of	cells,(
R4681	T5987	T5986	arg2Of	Fig.,(
R4682	T5987	T5988	arg1Of	Fig.,4
R4683	T5989	T5986	arg3Of	),(
R4684	T5990	T5992	arg1Of	We,assayed
R4685	T5992	T5991	arg1Of	assayed,also
R4686	T5992	T6000	arg1Of	assayed,in
R4687	T5993	T5992	arg2Of	activation,assayed
R4688	T5993	T5994	arg1Of	activation,of
R4689	T5999	T5994	arg2Of	JNK,of
R4690	T5999	T5995	arg1Of	JNK,the
R4691	T5999	T5996	arg1Of	JNK,stress-activated
R4692	T5999	T5997	arg1Of	JNK,protein
R4693	T5999	T5998	arg1Of	JNK,kinase
R4694	T6001	T6000	arg2Of	response,in
R4695	T6001	T6002	arg1Of	response,to
R4696	T6004	T6002	arg2Of	engagement,to
R4697	T6004	T6003	arg1Of	engagement,CD40
R4698	T6004	T6005	arg1Of	engagement,(
R4699	T6006	T6005	arg2Of	Fig.,(
R4700	T6006	T6007	arg1Of	Fig.,4
R4701	T6008	T6005	arg3Of	),(
R4702	T6011	T6009	arg1Of	activation,CD40-mediated
R4703	T6011	T6010	arg1Of	activation,JNK
R4704	T6011	T6012	arg1Of	activation,in
R4705	T6011	T6015	arg1Of	activation,was
R4706	T6011	T6016	arg2Of	activation,impaired
R4707	T6014	T6012	arg2Of	cells,in
R4708	T6014	T6013	arg1Of	cells,HOIP-deficient
R4709	T6016	T6015	arg2Of	impaired,was
R4710	T6016	T6017	arg1Of	impaired,as
R4711	T6018	T6017	arg2Of	measured,as
R4712	T6020	T6018	arg1Of	phosphorylation,measured
R4713	T6020	T6019	arg2Of	phosphorylation,by
R4714	T6020	T6021	arg1Of	phosphorylation,of
R4715	T6022	T6023	arg1Of	Thr183,and
R4716	T6023	T6021	arg2Of	and,of
R4717	T6023	T6025	arg1Of	and,in
R4718	T6024	T6023	arg2Of	Tyr185,and
R4719	T6026	T6025	arg2Of	JNK,in
R4720	T6028	T6027	arg1Of	activation,CD40-induced
R4721	T6028	T6029	arg1Of	activation,of
R4722	T6028	T6033	arg1Of	activation,in
R4723	T6028	T6036	arg1Of	activation,was
R4724	T6028	T6037	arg1Of	activation,normal
R4725	T6030	T6031	arg1Of	NF-κB,and
R4726	T6031	T6029	arg2Of	and,of
R4727	T6032	T6031	arg2Of	JNK,and
R4728	T6035	T6033	arg2Of	cells,in
R4729	T6035	T6034	arg1Of	cells,HOIP-reconstituted
R4730	T6036	T6038	arg1Of	was,","
R4731	T6036	T6039	modOf	was,demonstrating
R4732	T6037	T6036	arg2Of	normal,was
R4733	T6042	T6041	arg1Of	defects,the
R4734	T6042	T6043	arg2Of	defects,observed
R4735	T6042	T6047	arg1Of	defects,were
R4736	T6042	T6048	arg1Of	defects,due
R4737	T6043	T6044	arg1Of	observed,in
R4738	T6046	T6044	arg2Of	cells,in
R4739	T6046	T6045	arg1Of	cells,gene-deficient
R4740	T6047	T6039	arg2Of	were,demonstrating
R4741	T6047	T6040	arg1Of	were,that
R4742	T6048	T6047	arg2Of	due,were
R4743	T6048	T6049	arg1Of	due,to
R4744	T6051	T6049	arg2Of	absence,to
R4745	T6051	T6050	arg1Of	absence,the
R4746	T6051	T6052	arg1Of	absence,of
R4747	T6054	T6052	arg2Of	expression,of
R4748	T6054	T6053	arg1Of	expression,HOIP
R12939	T16375	T16374	arg1Of	activation,CD40-induced
R12940	T16375	T16376	arg1Of	activation,of
R12941	T16375	T16380	arg1Of	activation,is
R12942	T16375	T16381	arg1Of	activation,defective
R12943	T16377	T16378	arg1Of	NF-κB,and
R12944	T16378	T16376	arg2Of	and,of
R12945	T16379	T16378	arg2Of	JNK,and
R12946	T16380	T16382	arg1Of	is,in
R12947	T16381	T16380	arg2Of	defective,is
R12948	T16384	T16382	arg2Of	cells,in
R12949	T16384	T16383	arg1Of	cells,HOIP-deficient
R12950	T16386	T16385	arg1Of	signaling,CD40-mediated
R12951	T16386	T16387	arg1Of	signaling,was
R12952	T16386	T16388	arg1Of	signaling,defective
R12953	T16386	T16399	arg1Of	signaling,intact
R12954	T16388	T16389	arg1Of	defective,in
R12955	T16388	T16398	arg1Of	defective,but
R12956	T16391	T16389	arg2Of	cells,in
R12957	T16391	T16390	arg1Of	cells,HOIP-deficient
R12958	T16391	T16392	arg1Of	cells,(
R12959	T16393	T16392	arg2Of	HOIP-/-,(
R12960	T16393	T16394	arg1Of	HOIP-/-,+
R12961	T16393	T16395	arg1Of	HOIP-/-,pMIP
R12962	T16396	T16392	arg3Of	),(
R12963	T16398	T16387	arg2Of	but,was
R12964	T16398	T16397	arg1Of	but,","
R12965	T16399	T16398	arg2Of	intact,but
R12966	T16399	T16400	arg1Of	intact,in
R12967	T16402	T16400	arg2Of	cells,in
R12968	T16402	T16401	arg1Of	cells,parental
R12969	T16402	T16403	arg2Of	cells,transduced
R12970	T16403	T16404	arg1Of	transduced,with
R12971	T16403	T16415	arg1Of	transduced,in
R12972	T16404	T16414	arg1Of	with,and
R12973	T16408	T16404	arg2Of	vector,with
R12974	T16408	T16405	arg1Of	vector,an
R12975	T16408	T16406	arg1Of	vector,empty
R12976	T16408	T16407	arg1Of	vector,retroviral
R12977	T16408	T16409	arg1Of	vector,(
R12978	T16410	T16409	arg2Of	A20.2J,(
R12979	T16410	T16411	arg1Of	A20.2J,+
R12980	T16410	T16412	arg1Of	A20.2J,pMIP
R12981	T16413	T16409	arg3Of	),(
R12982	T16415	T16414	arg2Of	in,and
R12983	T16417	T16415	arg2Of	cells,in
R12984	T16417	T16416	arg1Of	cells,HOIP-deficient
R12985	T16417	T16418	arg2Of	cells,transduced
R12986	T16418	T16419	arg1Of	transduced,with
R12987	T16422	T16419	arg2Of	vector,with
R12988	T16422	T16420	arg1Of	vector,a
R12989	T16422	T16421	arg1Of	vector,retroviral
R12990	T16422	T16423	arg1Of	vector,encoding
R12991	T16424	T16423	arg2Of	HOIP,encoding
R12992	T16424	T16425	arg1Of	HOIP,(
R12993	T16426	T16425	arg2Of	HOIP-/-,(
R12994	T16426	T16427	arg1Of	HOIP-/-,+
R12995	T16426	T16428	arg1Of	HOIP-/-,HOIP
R12996	T16429	T16425	arg3Of	),(
R12997	T16430	T16431	arg1Of	Cells,were
R12998	T16430	T16432	arg2Of	Cells,activated
R12999	T16432	T16431	arg2Of	activated,were
R13000	T16432	T16433	arg1Of	activated,with
R13001	T16432	T16440	arg2Of	activated,indicated
R13002	T16435	T16433	arg2Of	insect,with
R13003	T16435	T16434	arg1Of	insect,CD154-expressing
R13004	T16436	T16437	arg1Of	cells,for
R13005	T16436	T16440	arg1Of	cells,indicated
R13006	T16439	T16437	arg2Of	times,for
R13007	T16439	T16438	arg1Of	times,the
R13008	T16444	T16441	arg2Of	control,As
R13009	T16444	T16442	arg1Of	control,a
R13010	T16444	T16443	arg1Of	control,negative
R13011	T16446	T16447	arg1Of	cells,were
R13012	T16446	T16448	arg2Of	cells,stimulated
R13013	T16448	T16441	arg1Of	stimulated,As
R13014	T16448	T16445	arg1Of	stimulated,","
R13015	T16448	T16447	arg2Of	stimulated,were
R13016	T16448	T16449	arg1Of	stimulated,with
R13017	T16451	T16449	arg2Of	cells,with
R13018	T16451	T16450	arg1Of	cells,insect
R13019	T16451	T16452	arg1Of	cells,lacking
R13020	T16453	T16452	arg2Of	CD154,lacking
R13021	T16453	T16454	arg1Of	CD154,(
R13022	T16458	T16454	arg2Of	point,(
R13023	T16458	T16455	arg1Of	point,5
R13024	T16458	T16456	arg1Of	point,minute
R13025	T16458	T16457	arg1Of	point,time
R13026	T16458	T16459	arg1Of	point,only
R13027	T16460	T16454	arg3Of	),(
R13028	T16462	T16461	arg1Of	blots,Western
R13029	T16462	T16463	arg1Of	blots,of
R13030	T16462	T16466	arg1Of	blots,were
R13031	T16462	T16467	arg2Of	blots,probed
R13032	T16465	T16463	arg2Of	lysates,of
R13033	T16465	T16464	arg1Of	lysates,whole-cell
R13034	T16467	T16466	arg2Of	probed,were
R13035	T16467	T16468	arg1Of	probed,with
R13036	T16471	T16468	arg2Of	antibodies,with
R13037	T16471	T16469	arg1Of	antibodies,the
R13038	T16471	T16470	arg1Of	antibodies,indicated
R13039	T16472	T16473	arg1Of	Phospho-IκBα,(
R13040	T16472	T16476	arg1Of	Phospho-IκBα,and
R13041	T16474	T16473	arg2Of	pIκBα,(
R13042	T16475	T16473	arg3Of	),(
R13043	T16476	T16482	arg1Of	and,were
R13044	T16476	T16483	arg2Of	and,stripped
R13045	T16476	T16485	arg2Of	and,reprobed
R13046	T16479	T16478	arg2Of	pJNK,(
R13047	T16480	T16478	arg3Of	),(
R13048	T16481	T16476	arg2Of	blots,and
R13049	T16481	T16477	arg1Of	blots,phospho-JNK
R13050	T16481	T16478	arg1Of	blots,(
R13051	T16483	T16484	arg1Of	stripped,and
R13052	T16484	T16482	arg2Of	and,were
R13053	T16484	T16486	arg1Of	and,for
R13054	T16484	T16492	arg1Of	and,","
R13055	T16485	T16484	arg2Of	reprobed,and
R13056	T16488	T16487	arg1Of	IκBα,total
R13057	T16488	T16489	arg1Of	IκBα,and
R13058	T16489	T16486	arg2Of	and,for
R13059	T16491	T16489	arg2Of	JNK,and
R13060	T16491	T16490	arg1Of	JNK,total
R13061	T16496	T16495	arg1Of	antibodies,anti-JNK
R13062	T16496	T16497	arg1Of	antibodies,recognize
R13063	T16497	T16492	arg2Of	recognize,","
R13064	T16497	T16493	arg1Of	recognize,respectively
R13065	T16497	T16494	arg1Of	recognize,(
R13066	T16497	T16502	arg1Of	recognize,)
R13067	T16498	T16499	arg1Of	p46,and
R13068	T16500	T16499	arg2Of	p54,and
R13069	T16501	T16497	arg2Of	isoforms,recognize
R13070	T16501	T16498	arg1Of	isoforms,p46
R13071	T16501	T16500	arg1Of	isoforms,p54
R13072	T16504	T16503	arg1Of	blots,IκBα
R13073	T16504	T16505	arg1Of	blots,were
R13074	T16504	T16507	arg2Of	blots,reprobed
R13075	T16504	T16511	arg1Of	blots,demonstrate
R13076	T16507	T16505	arg2Of	reprobed,were
R13077	T16507	T16506	arg1Of	reprobed,also
R13078	T16507	T16508	arg1Of	reprobed,for
R13079	T16509	T16508	arg2Of	actin,for
R13080	T16511	T16507	arg3Of	demonstrate,reprobed
R13081	T16511	T16510	arg1Of	demonstrate,to
R13082	T16514	T16511	arg2Of	loading,demonstrate
R13083	T16514	T16512	arg1Of	loading,equal
R13084	T16514	T16513	arg1Of	loading,lane
R13085	T16516	T16515	arg1Of	weights,Molecular
R13086	T16516	T16517	arg1Of	weights,are
R13087	T16516	T16518	arg2Of	weights,indicated
R13088	T16518	T16517	arg2Of	indicated,are
R13089	T16518	T16519	arg1Of	indicated,at
R13090	T16520	T16519	arg2Of	right,at
R13091	T16522	T16521	arg1Of	results,Similar
R13092	T16522	T16523	arg1Of	results,were
R13093	T16522	T16524	arg2Of	results,obtained
R13094	T16524	T16523	arg2Of	obtained,were
R13095	T16524	T16525	arg1Of	obtained,in
R13096	T16524	T16530	arg1Of	obtained,in
R13097	T16524	T16534	arg1Of	obtained,with
R13098	T16525	T16529	arg1Of	in,and
R13099	T16528	T16525	arg2Of	experiment,in
R13100	T16528	T16526	arg1Of	experiment,a
R13101	T16528	T16527	arg1Of	experiment,second
R13102	T16530	T16529	arg2Of	in,and
R13103	T16533	T16530	arg2Of	experiments,in
R13104	T16533	T16531	arg1Of	experiments,two
R13105	T16533	T16532	arg1Of	experiments,additional
R13106	T16538	T16534	arg2Of	clone,with
R13107	T16538	T16535	arg1Of	clone,a
R13108	T16538	T16536	arg1Of	clone,second
R13109	T16538	T16537	arg1Of	clone,HOIP-deficient

2_test

Id	Subject	Object	Predicate	Lexical cue
21829693-12958312-89653766	362-363	12958312	denotes	7
21829693-17878362-89653767	367-368	17878362	denotes	8
21829693-17633023-89653768	488-489	17633023	denotes	4
T39552	362-363	12958312	denotes	7
T34158	367-368	17878362	denotes	8
T9898	488-489	17633023	denotes	4

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T5508	0-4	NNP	denotes	HOIP
T5509	5-13	VBZ	denotes	mediates
T5510	14-29	JJ	denotes	CD40-stimulated
T5511	30-35	NN	denotes	NF-κB
T5512	36-39	CC	denotes	and
T5513	40-43	NNP	denotes	JNK
T5514	44-54	NN	denotes	activation
T5515	55-58	DT	denotes	The
T5516	59-66	NNS	denotes	results
T5517	67-76	VBN	denotes	described
T5518	77-82	IN	denotes	above
T5519	83-87	NN	denotes	show
T5520	88-92	IN	denotes	that
T5521	93-97	NNP	denotes	HOIP
T5522	98-103	VBZ	denotes	plays
T5523	104-106	DT	denotes	an
T5524	107-116	JJ	denotes	important
T5525	117-121	NN	denotes	role
T5526	122-124	IN	denotes	in
T5527	125-138	JJ	denotes	CD40-mediated
T5528	139-147	NN	denotes	effector
T5529	148-157	NNS	denotes	functions
T5530	158-160	IN	denotes	of
T5531	161-162	NNP	denotes	B
T5532	163-168	NNS	denotes	cells
T5533	168-169	.	denotes	.
T5534	170-172	PRP	denotes	It
T5535	173-180	VBZ	denotes	follows
T5536	181-185	IN	denotes	that
T5537	186-190	NNP	denotes	HOIP
T5538	191-193	VBZ	denotes	is
T5539	194-200	JJ	denotes	likely
T5540	201-202	DT	denotes	a
T5541	203-206	JJ	denotes	key
T5542	207-215	NN	denotes	mediator
T5543	216-218	IN	denotes	of
T5544	219-223	NNP	denotes	CD40
T5545	224-233	VBG	denotes	signaling
T5546	233-234	.	denotes	.
T5547	235-237	TO	denotes	To
T5548	238-242	VB	denotes	test
T5549	243-247	DT	denotes	this
T5550	248-258	NN	denotes	hypothesis
T5551	258-259	,	denotes	,
T5552	260-262	PRP	denotes	we
T5553	263-273	VBD	denotes	stimulated
T5554	274-277	NNP	denotes	A20
T5555	277-279	CD	denotes	.2
T5556	279-280	NNP	denotes	J
T5557	281-284	CC	denotes	and
T5558	285-299	JJ	denotes	HOIP-deficient
T5559	300-305	NNS	denotes	cells
T5560	306-310	IN	denotes	with
T5561	311-316	NNP	denotes	CD154
T5562	317-318	-LRB-	denotes	(
T5563	318-322	NNP	denotes	CD40
T5564	323-329	NN	denotes	ligand
T5565	329-330	-RRB-	denotes	)
T5566	331-340	VBN	denotes	expressed
T5567	341-343	IN	denotes	by
T5568	344-347	CD	denotes	HI5
T5569	348-354	JJ	denotes	insect
T5570	355-360	NNS	denotes	cells
T5571	361-362	VBP	denotes	[
T5572	362-363	CD	denotes	7
T5573	363-364	NNP	denotes	]
T5574	364-365	,	denotes	,
T5575	366-367	NNP	denotes	[
T5576	367-368	CD	denotes	8
T5577	368-369	NNP	denotes	]
T5578	370-373	CC	denotes	and
T5579	374-382	VBN	denotes	measured
T5580	383-393	NN	denotes	activation
T5581	394-396	IN	denotes	of
T5582	397-400	DT	denotes	the
T5583	401-406	NNP	denotes	NF-κB
T5584	407-410	CC	denotes	and
T5585	411-414	NNP	denotes	JNK
T5586	415-423	NNS	denotes	pathways
T5587	423-424	,	denotes	,
T5588	425-428	CD	denotes	two
T5589	429-431	IN	denotes	of
T5590	432-435	DT	denotes	the
T5591	436-441	JJ	denotes	major
T5592	442-457	JJ	denotes	transcriptional
T5593	458-468	NNS	denotes	regulators
T5594	469-478	VBN	denotes	activated
T5595	479-481	IN	denotes	by
T5596	482-486	NNP	denotes	CD40
T5597	487-488	NNP	denotes	[
T5598	488-489	CD	denotes	4
T5599	489-490	NNP	denotes	]
T5600	490-491	.	denotes	.
T5601	492-507	JJ	denotes	Cell-associated
T5602	508-513	NNP	denotes	CD154
T5603	514-517	VBD	denotes	was
T5604	518-522	VBN	denotes	used
T5605	523-525	IN	denotes	as
T5606	526-529	DT	denotes	the
T5607	530-538	NN	denotes	stimulus
T5608	539-541	IN	denotes	in
T5609	542-547	DT	denotes	these
T5610	548-559	NNS	denotes	experiments
T5611	560-562	IN	denotes	as
T5612	563-565	PRP	denotes	it
T5613	566-575	RB	denotes	typically
T5614	576-584	VBZ	denotes	provides
T5615	585-589	JJR	denotes	more
T5616	590-596	JJ	denotes	robust
T5617	596-597	,	denotes	,
T5618	598-601	CC	denotes	and
T5619	602-611	RB	denotes	therefore
T5620	612-616	RBR	denotes	more
T5621	617-624	RB	denotes	readily
T5622	625-633	VBN	denotes	detected
T5623	633-634	,	denotes	,
T5624	635-645	NN	denotes	activation
T5625	646-653	NNS	denotes	signals
T5626	654-658	IN	denotes	than
T5627	659-663	VBZ	denotes	does
T5628	664-673	JJ	denotes	anti-CD40
T5629	674-682	NN	denotes	antibody
T5630	682-683	.	denotes	.
T5631	684-694	NNP	denotes	Activation
T5632	695-697	IN	denotes	of
T5633	698-701	DT	denotes	the
T5634	702-711	JJ	denotes	canonical
T5635	712-717	NN	denotes	NF-κB
T5636	718-725	NN	denotes	pathway
T5637	726-728	VBZ	denotes	is
T5638	729-738	VBN	denotes	initiated
T5639	739-743	IN	denotes	with
T5640	744-747	DT	denotes	the
T5641	748-763	NN	denotes	phosphorylation
T5642	764-766	IN	denotes	of
T5643	767-770	NNP	denotes	IκB
T5644	771-779	NNS	denotes	proteins
T5645	780-782	IN	denotes	by
T5646	783-786	DT	denotes	the
T5647	787-790	NNP	denotes	IκB
T5648	791-797	NN	denotes	kinase
T5649	798-805	NN	denotes	complex
T5650	806-807	-LRB-	denotes	(
T5651	807-810	NNP	denotes	IKK
T5652	810-811	-RRB-	denotes	)
T5653	811-812	.	denotes	.
T5654	813-815	IN	denotes	In
T5655	816-823	VBG	denotes	resting
T5656	824-829	NNS	denotes	cells
T5657	829-830	,	denotes	,
T5658	831-834	NNP	denotes	IκB
T5659	835-843	NNS	denotes	proteins
T5660	844-847	VBP	denotes	are
T5661	848-859	JJ	denotes	responsible
T5662	860-863	IN	denotes	for
T5663	864-876	NN	denotes	sequestering
T5664	877-882	NN	denotes	NF-κB
T5665	883-891	NNS	denotes	subunits
T5666	892-894	IN	denotes	in
T5667	895-898	DT	denotes	the
T5668	899-908	NN	denotes	cytoplasm
T5669	908-909	.	denotes	.
T5670	910-925	NN	denotes	Phosphorylation
T5671	926-928	IN	denotes	by
T5672	929-932	DT	denotes	the
T5673	933-936	NNP	denotes	IKK
T5674	937-944	JJ	denotes	complex
T5675	945-952	NNS	denotes	targets
T5676	953-956	VBP	denotes	IκB
T5677	957-965	NNS	denotes	proteins
T5678	966-969	IN	denotes	for
T5679	970-984	NN	denotes	ubiquitination
T5680	985-988	CC	denotes	and
T5681	989-1000	NN	denotes	degradation
T5682	1000-1001	,	denotes	,
T5683	1002-1010	VBG	denotes	allowing
T5684	1011-1016	NN	denotes	NF-κB
T5685	1017-1019	TO	denotes	to
T5686	1020-1025	VB	denotes	enter
T5687	1026-1029	DT	denotes	the
T5688	1030-1037	NN	denotes	nucleus
T5689	1038-1041	CC	denotes	and
T5690	1042-1050	VB	denotes	activate
T5691	1051-1055	NN	denotes	gene
T5692	1056-1066	NN	denotes	expression
T5693	1066-1067	.	denotes	.
T5694	1068-1081	JJ	denotes	CD40-mediated
T5695	1082-1097	NN	denotes	phosphorylation
T5696	1098-1101	CC	denotes	and
T5697	1102-1113	NN	denotes	degradation
T5698	1114-1116	IN	denotes	of
T5699	1117-1121	NNP	denotes	IκBα
T5700	1122-1124	IN	denotes	in
T5701	1125-1139	JJ	denotes	HOIP-deficient
T5702	1140-1145	NNS	denotes	cells
T5703	1146-1149	VBD	denotes	was
T5704	1150-1162	RB	denotes	dramatically
T5705	1163-1171	VBN	denotes	impaired
T5706	1172-1180	JJ	denotes	relative
T5707	1181-1183	TO	denotes	to
T5708	1184-1188	DT	denotes	that
T5709	1189-1197	VBN	denotes	observed
T5710	1198-1200	IN	denotes	in
T5711	1201-1209	JJ	denotes	parental
T5712	1210-1213	NNP	denotes	A20
T5713	1213-1215	CD	denotes	.2
T5714	1215-1216	NNP	denotes	J
T5715	1217-1222	NNS	denotes	cells
T5716	1223-1224	-LRB-	denotes	(
T5717	1224-1228	JJ	denotes	Fig.
T5718	1229-1230	CD	denotes	4
T5719	1230-1231	-RRB-	denotes	)
T5720	1231-1232	.	denotes	.
T5721	1233-1235	PRP	denotes	We
T5722	1236-1240	RB	denotes	also
T5723	1241-1248	VBD	denotes	assayed
T5724	1249-1259	NN	denotes	activation
T5725	1260-1262	IN	denotes	of
T5726	1263-1266	DT	denotes	the
T5727	1267-1283	JJ	denotes	stress-activated
T5728	1284-1291	NN	denotes	protein
T5729	1292-1298	NN	denotes	kinase
T5730	1299-1302	NNP	denotes	JNK
T5731	1303-1305	IN	denotes	in
T5732	1306-1314	NN	denotes	response
T5733	1315-1317	TO	denotes	to
T5734	1318-1322	CD	denotes	CD40
T5735	1323-1333	NN	denotes	engagement
T5736	1334-1335	-LRB-	denotes	(
T5737	1335-1339	FW	denotes	Fig.
T5738	1340-1341	LS	denotes	4
T5739	1341-1342	-RRB-	denotes	)
T5740	1342-1343	.	denotes	.
T5741	1344-1357	JJ	denotes	CD40-mediated
T5742	1358-1361	NNP	denotes	JNK
T5743	1362-1372	NN	denotes	activation
T5744	1373-1375	IN	denotes	in
T5745	1376-1390	JJ	denotes	HOIP-deficient
T5746	1391-1396	NNS	denotes	cells
T5747	1397-1400	VBD	denotes	was
T5748	1401-1409	VBN	denotes	impaired
T5749	1410-1412	IN	denotes	as
T5750	1413-1421	VBN	denotes	measured
T5751	1422-1424	IN	denotes	by
T5752	1425-1440	NN	denotes	phosphorylation
T5753	1441-1443	IN	denotes	of
T5754	1444-1450	NNP	denotes	Thr183
T5755	1451-1454	CC	denotes	and
T5756	1455-1461	NNP	denotes	Tyr185
T5757	1462-1464	IN	denotes	in
T5758	1465-1468	NNP	denotes	JNK
T5759	1468-1469	.	denotes	.
T5760	1470-1482	JJ	denotes	CD40-induced
T5761	1483-1493	NN	denotes	activation
T5762	1494-1496	IN	denotes	of
T5763	1497-1502	NNP	denotes	NF-κB
T5764	1503-1506	CC	denotes	and
T5765	1507-1510	NNP	denotes	JNK
T5766	1511-1513	IN	denotes	in
T5767	1514-1532	JJ	denotes	HOIP-reconstituted
T5768	1533-1538	NNS	denotes	cells
T5769	1539-1542	VBD	denotes	was
T5770	1543-1549	JJ	denotes	normal
T5771	1549-1550	,	denotes	,
T5772	1551-1564	VBG	denotes	demonstrating
T5773	1565-1569	IN	denotes	that
T5774	1570-1573	DT	denotes	the
T5775	1574-1581	NNS	denotes	defects
T5776	1582-1590	VBD	denotes	observed
T5777	1591-1593	IN	denotes	in
T5778	1594-1608	JJ	denotes	gene-deficient
T5779	1609-1614	NNS	denotes	cells
T5780	1615-1619	VBD	denotes	were
T5781	1620-1623	JJ	denotes	due
T5782	1624-1626	TO	denotes	to
T5783	1627-1630	DT	denotes	the
T5784	1631-1638	NN	denotes	absence
T5785	1639-1641	IN	denotes	of
T5786	1642-1646	NNP	denotes	HOIP
T5787	1647-1657	NN	denotes	expression
T5788	1657-1658	.	denotes	.
T6738	937-944	NN	denotes	complex
T16192	1703-1715	JJ	denotes	CD40-induced
T16193	1716-1726	NN	denotes	activation
T16194	1727-1729	IN	denotes	of
T16195	1730-1735	NNP	denotes	NF-κB
T16196	1736-1739	CC	denotes	and
T16197	1740-1743	NNP	denotes	JNK
T16198	1744-1746	VBZ	denotes	is
T16199	1747-1756	JJ	denotes	defective
T16200	1757-1759	IN	denotes	in
T16201	1760-1774	JJ	denotes	HOIP-deficient
T16202	1775-1780	NNS	denotes	cells
T16203	1780-1781	.	denotes	.
T16204	1782-1795	JJ	denotes	CD40-mediated
T16205	1796-1805	VBG	denotes	signaling
T16206	1806-1809	VBD	denotes	was
T16207	1810-1819	JJ	denotes	defective
T16208	1820-1822	IN	denotes	in
T16209	1823-1837	JJ	denotes	HOIP-deficient
T16210	1838-1843	NNS	denotes	cells
T16211	1844-1845	-LRB-	denotes	(
T16212	1845-1849	SYM	denotes	HOIP
T16213	1849-1850	:	denotes	-
T16214	1850-1851	SYM	denotes	/
T16215	1851-1852	:	denotes	-
T16216	1853-1854	NN	denotes	+
T16217	1855-1859	NNP	denotes	pMIP
T16218	1859-1860	-RRB-	denotes	)
T16219	1860-1861	,	denotes	,
T16220	1862-1865	CC	denotes	but
T16221	1866-1872	JJ	denotes	intact
T16222	1873-1875	IN	denotes	in
T16223	1876-1884	JJ	denotes	parental
T16224	1885-1890	NNS	denotes	cells
T16225	1891-1901	VBN	denotes	transduced
T16226	1902-1906	IN	denotes	with
T16227	1907-1909	DT	denotes	an
T16228	1910-1915	JJ	denotes	empty
T16229	1916-1926	NN	denotes	retroviral
T16230	1927-1933	NN	denotes	vector
T16231	1934-1935	-LRB-	denotes	(
T16232	1935-1938	CD	denotes	A20
T16233	1938-1940	CD	denotes	.2
T16234	1940-1941	NNP	denotes	J
T16235	1942-1943	CD	denotes	+
T16236	1944-1948	NNP	denotes	pMIP
T16237	1948-1949	-RRB-	denotes	)
T16238	1950-1953	CC	denotes	and
T16239	1954-1956	IN	denotes	in
T16240	1957-1971	JJ	denotes	HOIP-deficient
T16241	1972-1977	NNS	denotes	cells
T16242	1978-1988	VBN	denotes	transduced
T16243	1989-1993	IN	denotes	with
T16244	1994-1995	DT	denotes	a
T16245	1996-2006	JJ	denotes	retroviral
T16246	2007-2013	NN	denotes	vector
T16247	2014-2022	VBG	denotes	encoding
T16248	2023-2027	NNP	denotes	HOIP
T16249	2028-2029	-LRB-	denotes	(
T16250	2029-2033	NNP	denotes	HOIP
T16251	2033-2034	:	denotes	-
T16252	2034-2035	SYM	denotes	/
T16253	2035-2036	:	denotes	-
T16254	2037-2038	NN	denotes	+
T16255	2039-2043	NNP	denotes	HOIP
T16256	2043-2044	-RRB-	denotes	)
T16257	2044-2045	.	denotes	.
T16258	2046-2051	NNS	denotes	Cells
T16259	2052-2056	VBD	denotes	were
T16260	2057-2066	VBN	denotes	activated
T16261	2067-2071	IN	denotes	with
T16262	2072-2088	JJ	denotes	CD154-expressing
T16263	2089-2095	NN	denotes	insect
T16264	2096-2101	NNS	denotes	cells
T16265	2102-2105	IN	denotes	for
T16266	2106-2109	DT	denotes	the
T16267	2110-2115	NNS	denotes	times
T16268	2116-2125	VBD	denotes	indicated
T16269	2125-2126	.	denotes	.
T16270	2127-2129	IN	denotes	As
T16271	2130-2131	DT	denotes	a
T16272	2132-2140	JJ	denotes	negative
T16273	2141-2148	NN	denotes	control
T16274	2148-2149	,	denotes	,
T16275	2150-2155	NNS	denotes	cells
T16276	2156-2160	VBD	denotes	were
T16277	2161-2171	VBN	denotes	stimulated
T16278	2172-2176	IN	denotes	with
T16279	2177-2183	JJ	denotes	insect
T16280	2184-2189	NNS	denotes	cells
T16281	2190-2197	VBG	denotes	lacking
T16282	2198-2203	NNP	denotes	CD154
T16283	2204-2205	-LRB-	denotes	(
T16284	2205-2206	CD	denotes	5
T16285	2207-2213	JJ	denotes	minute
T16286	2214-2218	NN	denotes	time
T16287	2219-2224	NN	denotes	point
T16288	2225-2229	RB	denotes	only
T16289	2229-2230	-RRB-	denotes	)
T16290	2230-2231	.	denotes	.
T16291	2232-2239	JJ	denotes	Western
T16292	2240-2245	NNS	denotes	blots
T16293	2246-2248	IN	denotes	of
T16294	2249-2259	JJ	denotes	whole-cell
T16295	2260-2267	NNS	denotes	lysates
T16296	2268-2272	VBD	denotes	were
T16297	2273-2279	VBN	denotes	probed
T16298	2280-2284	IN	denotes	with
T16299	2285-2288	DT	denotes	the
T16300	2289-2298	VBN	denotes	indicated
T16301	2299-2309	NNS	denotes	antibodies
T16302	2309-2310	.	denotes	.
T16303	2311-2323	NNP	denotes	Phospho-IκBα
T16304	2324-2325	-LRB-	denotes	(
T16305	2325-2330	NNP	denotes	pIκBα
T16306	2330-2331	-RRB-	denotes	)
T16307	2332-2335	CC	denotes	and
T16308	2336-2347	NNP	denotes	phospho-JNK
T16309	2348-2349	-LRB-	denotes	(
T16310	2349-2353	NNP	denotes	pJNK
T16311	2353-2354	-RRB-	denotes	)
T16312	2355-2360	NNS	denotes	blots
T16313	2361-2365	VBD	denotes	were
T16314	2366-2374	VBN	denotes	stripped
T16315	2375-2378	CC	denotes	and
T16316	2379-2387	VBN	denotes	reprobed
T16317	2388-2391	IN	denotes	for
T16318	2392-2397	JJ	denotes	total
T16319	2398-2402	NNP	denotes	IκBα
T16320	2403-2406	CC	denotes	and
T16321	2407-2412	JJ	denotes	total
T16322	2413-2416	NNP	denotes	JNK
T16323	2416-2417	,	denotes	,
T16324	2418-2430	RB	denotes	respectively
T16325	2431-2432	-LRB-	denotes	(
T16326	2432-2440	JJ	denotes	anti-JNK
T16327	2441-2451	NNS	denotes	antibodies
T16328	2452-2461	VBP	denotes	recognize
T16329	2462-2465	CD	denotes	p46
T16330	2466-2469	CC	denotes	and
T16331	2470-2473	CD	denotes	p54
T16332	2474-2482	NNS	denotes	isoforms
T16333	2482-2483	-RRB-	denotes	)
T16334	2483-2484	.	denotes	.
T16335	2485-2489	NNP	denotes	IκBα
T16336	2490-2495	NNS	denotes	blots
T16337	2496-2500	VBD	denotes	were
T16338	2501-2505	RB	denotes	also
T16339	2506-2514	VBN	denotes	reprobed
T16340	2515-2518	IN	denotes	for
T16341	2519-2524	NN	denotes	actin
T16342	2525-2527	TO	denotes	to
T16343	2528-2539	VB	denotes	demonstrate
T16344	2540-2545	JJ	denotes	equal
T16345	2546-2550	NN	denotes	lane
T16346	2551-2558	VBG	denotes	loading
T16347	2558-2559	.	denotes	.
T16348	2560-2569	JJ	denotes	Molecular
T16349	2570-2577	NNS	denotes	weights
T16350	2578-2581	VBP	denotes	are
T16351	2582-2591	VBN	denotes	indicated
T16352	2592-2594	IN	denotes	at
T16353	2595-2600	NN	denotes	right
T16354	2600-2601	.	denotes	.
T16355	2602-2609	JJ	denotes	Similar
T16356	2610-2617	NNS	denotes	results
T16357	2618-2622	VBD	denotes	were
T16358	2623-2631	VBN	denotes	obtained
T16359	2632-2634	IN	denotes	in
T16360	2635-2636	DT	denotes	a
T16361	2637-2643	JJ	denotes	second
T16362	2644-2654	NN	denotes	experiment
T16363	2655-2658	CC	denotes	and
T16364	2659-2661	IN	denotes	in
T16365	2662-2665	CD	denotes	two
T16366	2666-2676	JJ	denotes	additional
T16367	2677-2688	NNS	denotes	experiments
T16368	2689-2693	IN	denotes	with
T16369	2694-2695	DT	denotes	a
T16370	2696-2702	JJ	denotes	second
T16371	2703-2717	JJ	denotes	HOIP-deficient
T16372	2718-2723	NN	denotes	clone
T16373	2723-2724	.	denotes	.
R4202	T5508	T5509	nsubj	HOIP,mediates
R4203	T5509	T5509	ROOT	mediates,mediates
R4204	T5510	T5511	amod	CD40-stimulated,NF-κB
R4205	T5511	T5509	dobj	NF-κB,mediates
R4206	T5512	T5511	cc	and,NF-κB
R4207	T5513	T5514	compound	JNK,activation
R4208	T5514	T5511	conj	activation,NF-κB
R4209	T5515	T5516	det	The,results
R4210	T5516	T5509	dobj	results,mediates
R4211	T5517	T5516	acl	described,results
R4212	T5518	T5517	prep	above,described
R4213	T5519	T5518	pobj	show,above
R4214	T5520	T5522	mark	that,plays
R4215	T5521	T5522	nsubj	HOIP,plays
R4216	T5522	T5519	ccomp	plays,show
R4217	T5523	T5525	det	an,role
R4218	T5524	T5525	amod	important,role
R4219	T5525	T5522	dobj	role,plays
R4220	T5526	T5525	prep	in,role
R4221	T5527	T5529	amod	CD40-mediated,functions
R4222	T5528	T5529	compound	effector,functions
R4223	T5529	T5526	pobj	functions,in
R4224	T5530	T5529	prep	of,functions
R4225	T5531	T5532	compound	B,cells
R4226	T5532	T5530	pobj	cells,of
R4227	T5533	T5509	punct	.,mediates
R4228	T5534	T5535	nsubj	It,follows
R4229	T5535	T5535	ROOT	follows,follows
R4230	T5536	T5538	mark	that,is
R4231	T5537	T5538	nsubj	HOIP,is
R4232	T5538	T5535	ccomp	is,follows
R4233	T5539	T5538	acomp	likely,is
R4234	T5540	T5542	det	a,mediator
R4235	T5541	T5542	amod	key,mediator
R4236	T5542	T5539	pobj	mediator,likely
R4237	T5543	T5542	prep	of,mediator
R4238	T5544	T5543	pobj	CD40,of
R4239	T5545	T5542	acl	signaling,mediator
R4240	T5546	T5535	punct	.,follows
R4241	T5547	T5548	aux	To,test
R4242	T5548	T5553	advcl	test,stimulated
R4243	T5549	T5550	det	this,hypothesis
R4244	T5550	T5548	dobj	hypothesis,test
R4245	T5551	T5553	punct	",",stimulated
R4246	T5552	T5553	nsubj	we,stimulated
R4247	T5553	T5553	ROOT	stimulated,stimulated
R4248	T5554	T5556	nmod	A20,J
R4249	T5555	T5556	nummod	.2,J
R4250	T5556	T5553	dobj	J,stimulated
R4251	T5557	T5556	cc	and,J
R4252	T5558	T5559	amod	HOIP-deficient,cells
R4253	T5559	T5556	conj	cells,J
R4254	T5560	T5553	prep	with,stimulated
R4255	T5561	T5560	pobj	CD154,with
R4256	T5562	T5561	punct	(,CD154
R4257	T5563	T5564	compound	CD40,ligand
R4258	T5564	T5561	appos	ligand,CD154
R4259	T5565	T5561	punct	),CD154
R4260	T5566	T5553	advcl	expressed,stimulated
R4261	T5567	T5566	agent	by,expressed
R4262	T5568	T5570	nummod	HI5,cells
R4263	T5569	T5570	compound	insect,cells
R4264	T5570	T5567	pobj	cells,by
R4265	T5571	T5573	nmod	[,]
R4266	T5572	T5573	nummod	7,]
R4267	T5573	T5553	npadvmod	],stimulated
R4268	T5574	T5573	punct	",",]
R4269	T5575	T5577	compound	[,]
R4270	T5576	T5577	nummod	8,]
R4271	T5577	T5573	conj	],]
R4272	T5578	T5577	cc	and,]
R4273	T5579	T5580	amod	measured,activation
R4274	T5580	T5577	conj	activation,]
R4275	T5581	T5580	prep	of,activation
R4276	T5582	T5583	det	the,NF-κB
R4277	T5583	T5581	pobj	NF-κB,of
R4278	T5584	T5583	cc	and,NF-κB
R4279	T5585	T5583	conj	JNK,NF-κB
R4280	T5586	T5580	conj	pathways,activation
R4281	T5587	T5586	punct	",",pathways
R4282	T5588	T5586	appos	two,pathways
R4283	T5589	T5588	prep	of,two
R4284	T5590	T5593	det	the,regulators
R4285	T5591	T5593	amod	major,regulators
R4286	T5592	T5593	amod	transcriptional,regulators
R4287	T5593	T5589	pobj	regulators,of
R4288	T5594	T5588	acl	activated,two
R4289	T5595	T5594	agent	by,activated
R4290	T5596	T5597	compound	CD40,[
R4291	T5597	T5595	pobj	[,by
R4292	T5598	T5599	nummod	4,]
R4293	T5599	T5597	appos	],[
R4294	T5600	T5553	punct	.,stimulated
R4295	T5601	T5602	compound	Cell-associated,CD154
R4296	T5602	T5604	nsubjpass	CD154,used
R4297	T5603	T5604	auxpass	was,used
R4298	T5604	T5604	ROOT	used,used
R4299	T5605	T5604	prep	as,used
R4300	T5606	T5607	det	the,stimulus
R4301	T5607	T5605	pobj	stimulus,as
R4302	T5608	T5607	prep	in,stimulus
R4303	T5609	T5610	det	these,experiments
R4304	T5610	T5608	pobj	experiments,in
R4305	T5611	T5614	mark	as,provides
R4306	T5612	T5614	nsubj	it,provides
R4307	T5613	T5614	advmod	typically,provides
R4308	T5614	T5604	advcl	provides,used
R4309	T5615	T5616	advmod	more,robust
R4310	T5616	T5614	advmod	robust,provides
R4311	T5617	T5614	punct	",",provides
R4312	T5618	T5614	cc	and,provides
R4313	T5619	T5622	advmod	therefore,detected
R4314	T5620	T5621	advmod	more,readily
R4315	T5621	T5622	advmod	readily,detected
R4316	T5622	T5625	amod	detected,signals
R4317	T5623	T5625	punct	",",signals
R4318	T5624	T5625	compound	activation,signals
R4319	T5625	T5614	conj	signals,provides
R4320	T5626	T5627	mark	than,does
R4321	T5627	T5625	advcl	does,signals
R4322	T5628	T5629	amod	anti-CD40,antibody
R4323	T5629	T5627	nsubj	antibody,does
R4324	T5630	T5604	punct	.,used
R4325	T5631	T5638	nsubjpass	Activation,initiated
R4326	T5632	T5631	prep	of,Activation
R4327	T5633	T5636	det	the,pathway
R4328	T5634	T5636	amod	canonical,pathway
R4329	T5635	T5636	compound	NF-κB,pathway
R4330	T5636	T5632	pobj	pathway,of
R4331	T5637	T5638	auxpass	is,initiated
R4332	T5638	T5638	ROOT	initiated,initiated
R4333	T5639	T5638	prep	with,initiated
R4334	T5640	T5641	det	the,phosphorylation
R4335	T5641	T5639	pobj	phosphorylation,with
R4336	T5642	T5641	prep	of,phosphorylation
R4337	T5643	T5644	compound	IκB,proteins
R4338	T5644	T5642	pobj	proteins,of
R4339	T5645	T5641	prep	by,phosphorylation
R4340	T5646	T5649	det	the,complex
R4341	T5647	T5649	nmod	IκB,complex
R4342	T5648	T5649	compound	kinase,complex
R4343	T5649	T5645	pobj	complex,by
R4344	T5650	T5651	punct	(,IKK
R4345	T5651	T5649	appos	IKK,complex
R4346	T5652	T5651	punct	),IKK
R4347	T5653	T5638	punct	.,initiated
R4348	T5654	T5660	prep	In,are
R4349	T5655	T5656	amod	resting,cells
R4350	T5656	T5654	pobj	cells,In
R4351	T5657	T5660	punct	",",are
R4352	T5658	T5659	compound	IκB,proteins
R4353	T5659	T5660	nsubj	proteins,are
R4354	T5660	T5660	ROOT	are,are
R4355	T5661	T5660	acomp	responsible,are
R4356	T5662	T5661	prep	for,responsible
R4357	T5663	T5665	compound	sequestering,subunits
R4358	T5664	T5665	compound	NF-κB,subunits
R4359	T5665	T5662	pobj	subunits,for
R4360	T5666	T5665	prep	in,subunits
R4361	T5667	T5668	det	the,cytoplasm
R4362	T5668	T5666	pobj	cytoplasm,in
R4363	T5669	T5660	punct	.,are
R4364	T5670	T5670	ROOT	Phosphorylation,Phosphorylation
R4365	T5671	T5670	prep	by,Phosphorylation
R4366	T5672	T5675	det	the,targets
R4367	T5673	T5675	nmod	IKK,targets
R4368	T5674	T5675	amod	complex,targets
R4369	T5675	T5671	pobj	targets,by
R4370	T5676	T5677	amod	IκB,proteins
R4371	T5677	T5670	conj	proteins,Phosphorylation
R4372	T5678	T5677	prep	for,proteins
R4373	T5679	T5678	pobj	ubiquitination,for
R4374	T5680	T5679	cc	and,ubiquitination
R4375	T5681	T5679	conj	degradation,ubiquitination
R4376	T5682	T5677	punct	",",proteins
R4377	T5683	T5670	acl	allowing,Phosphorylation
R4378	T5684	T5686	nsubj	NF-κB,enter
R4379	T5685	T5686	aux	to,enter
R4380	T5686	T5683	ccomp	enter,allowing
R4381	T5687	T5688	det	the,nucleus
R4382	T5688	T5686	dobj	nucleus,enter
R4383	T5689	T5686	cc	and,enter
R4384	T5690	T5686	conj	activate,enter
R4385	T5691	T5692	compound	gene,expression
R4386	T5692	T5690	dobj	expression,activate
R4387	T5693	T5670	punct	.,Phosphorylation
R4388	T5694	T5695	amod	CD40-mediated,phosphorylation
R4389	T5695	T5705	nsubjpass	phosphorylation,impaired
R4390	T5696	T5695	cc	and,phosphorylation
R4391	T5697	T5695	conj	degradation,phosphorylation
R4392	T5698	T5697	prep	of,degradation
R4393	T5699	T5698	pobj	IκBα,of
R4394	T5700	T5697	prep	in,degradation
R4395	T5701	T5702	amod	HOIP-deficient,cells
R4396	T5702	T5700	pobj	cells,in
R4397	T5703	T5705	auxpass	was,impaired
R4398	T5704	T5705	advmod	dramatically,impaired
R4399	T5705	T5705	ROOT	impaired,impaired
R4400	T5706	T5705	oprd	relative,impaired
R4401	T5707	T5706	prep	to,relative
R4402	T5708	T5709	nsubj	that,observed
R4403	T5709	T5707	pobj	observed,to
R4404	T5710	T5709	prep	in,observed
R4405	T5711	T5715	amod	parental,cells
R4406	T5712	T5715	compound	A20,cells
R4407	T5713	T5714	compound	.2,J
R4408	T5714	T5715	compound	J,cells
R4409	T5715	T5710	pobj	cells,in
R4410	T5716	T5717	punct	(,Fig.
R4411	T5717	T5719	nmod	Fig.,)
R4412	T5718	T5717	nummod	4,Fig.
R4413	T5719	T5705	punct	),impaired
R4414	T5720	T5705	punct	.,impaired
R4415	T5721	T5723	nsubj	We,assayed
R4416	T5722	T5723	advmod	also,assayed
R4417	T5723	T5723	ROOT	assayed,assayed
R4418	T5724	T5723	dobj	activation,assayed
R4419	T5725	T5724	prep	of,activation
R4420	T5726	T5728	det	the,protein
R4421	T5727	T5728	amod	stress-activated,protein
R4422	T5728	T5725	pobj	protein,of
R4423	T5729	T5730	compound	kinase,JNK
R4424	T5730	T5728	appos	JNK,protein
R4425	T5731	T5723	prep	in,assayed
R4426	T5732	T5731	pobj	response,in
R4427	T5733	T5732	prep	to,response
R4428	T5734	T5735	nummod	CD40,engagement
R4429	T5735	T5733	pobj	engagement,to
R4430	T5736	T5738	punct	(,4
R4431	T5737	T5738	nmod	Fig.,4
R4432	T5738	T5735	appos	4,engagement
R4433	T5739	T5738	punct	),4
R4434	T5740	T5723	punct	.,assayed
R4435	T5741	T5743	amod	CD40-mediated,activation
R4436	T5742	T5743	compound	JNK,activation
R4437	T5743	T5748	nsubjpass	activation,impaired
R4438	T5744	T5743	prep	in,activation
R4439	T5745	T5746	amod	HOIP-deficient,cells
R4440	T5746	T5744	pobj	cells,in
R4441	T5747	T5748	auxpass	was,impaired
R4442	T5748	T5748	ROOT	impaired,impaired
R4443	T5749	T5750	mark	as,measured
R4444	T5750	T5748	advcl	measured,impaired
R4445	T5751	T5750	agent	by,measured
R4446	T5752	T5751	pobj	phosphorylation,by
R4447	T5753	T5752	prep	of,phosphorylation
R4448	T5754	T5753	pobj	Thr183,of
R4449	T5755	T5754	cc	and,Thr183
R4450	T5756	T5754	conj	Tyr185,Thr183
R4451	T5757	T5752	prep	in,phosphorylation
R4452	T5758	T5757	pobj	JNK,in
R4453	T5759	T5748	punct	.,impaired
R4454	T5760	T5761	amod	CD40-induced,activation
R4455	T5761	T5769	nsubj	activation,was
R4456	T5762	T5761	prep	of,activation
R4457	T5763	T5762	pobj	NF-κB,of
R4458	T5764	T5763	cc	and,NF-κB
R4459	T5765	T5763	conj	JNK,NF-κB
R4460	T5766	T5761	prep	in,activation
R4461	T5767	T5768	amod	HOIP-reconstituted,cells
R4462	T5768	T5766	pobj	cells,in
R4463	T5769	T5769	ROOT	was,was
R4464	T5770	T5769	acomp	normal,was
R4465	T5771	T5769	punct	",",was
R4466	T5772	T5769	advcl	demonstrating,was
R4467	T5773	T5776	mark	that,observed
R4468	T5774	T5775	det	the,defects
R4469	T5775	T5776	nsubj	defects,observed
R4470	T5776	T5772	ccomp	observed,demonstrating
R4471	T5777	T5776	prep	in,observed
R4472	T5778	T5779	amod	gene-deficient,cells
R4473	T5779	T5777	pobj	cells,in
R4474	T5780	T5769	conj	were,was
R4475	T5781	T5780	acomp	due,were
R4476	T5782	T5781	prep	to,due
R4477	T5783	T5784	det	the,absence
R4478	T5784	T5782	pobj	absence,to
R4479	T5785	T5784	prep	of,absence
R4480	T5786	T5787	compound	HOIP,expression
R4481	T5787	T5785	pobj	expression,of
R4482	T5788	T5769	punct	.,was
R12757	T16192	T16193	amod	CD40-induced,activation
R12758	T16193	T16198	nsubj	activation,is
R12759	T16194	T16193	prep	of,activation
R12760	T16195	T16194	pobj	NF-κB,of
R12761	T16196	T16195	cc	and,NF-κB
R12762	T16197	T16195	conj	JNK,NF-κB
R12763	T16198	T16198	ROOT	is,is
R12764	T16199	T16198	acomp	defective,is
R12765	T16200	T16199	prep	in,defective
R12766	T16201	T16202	amod	HOIP-deficient,cells
R12767	T16202	T16200	pobj	cells,in
R12768	T16203	T16198	punct	.,is
R12769	T16204	T16205	amod	CD40-mediated,signaling
R12770	T16205	T16206	nsubj	signaling,was
R12771	T16206	T16206	ROOT	was,was
R12772	T16207	T16206	acomp	defective,was
R12773	T16208	T16207	prep	in,defective
R12774	T16209	T16210	amod	HOIP-deficient,cells
R12775	T16210	T16208	pobj	cells,in
R12776	T16211	T16216	punct	(,+
R12777	T16212	T16216	punct	HOIP,+
R12778	T16213	T16216	punct	-,+
R12779	T16214	T16216	punct	/,+
R12780	T16215	T16216	punct	-,+
R12781	T16216	T16206	parataxis	+,was
R12782	T16217	T16216	npadvmod	pMIP,+
R12783	T16218	T16216	punct	),+
R12784	T16219	T16216	punct	",",+
R12785	T16220	T16216	cc	but,+
R12786	T16221	T16216	conj	intact,+
R12787	T16222	T16221	prep	in,intact
R12788	T16223	T16224	amod	parental,cells
R12789	T16224	T16222	pobj	cells,in
R12790	T16225	T16216	conj	transduced,+
R12791	T16226	T16225	prep	with,transduced
R12792	T16227	T16230	det	an,vector
R12793	T16228	T16230	amod	empty,vector
R12794	T16229	T16230	compound	retroviral,vector
R12795	T16230	T16226	pobj	vector,with
R12796	T16231	T16230	punct	(,vector
R12797	T16232	T16236	nummod	A20,pMIP
R12798	T16233	T16236	nummod	.2,pMIP
R12799	T16234	T16236	nmod	J,pMIP
R12800	T16235	T16236	nummod	+,pMIP
R12801	T16236	T16230	appos	pMIP,vector
R12802	T16237	T16236	punct	),pMIP
R12803	T16238	T16226	cc	and,with
R12804	T16239	T16225	prep	in,transduced
R12805	T16240	T16241	amod	HOIP-deficient,cells
R12806	T16241	T16239	pobj	cells,in
R12807	T16242	T16225	conj	transduced,transduced
R12808	T16243	T16242	prep	with,transduced
R12809	T16244	T16246	det	a,vector
R12810	T16245	T16246	amod	retroviral,vector
R12811	T16246	T16243	pobj	vector,with
R12812	T16247	T16248	compound	encoding,HOIP
R12813	T16248	T16246	appos	HOIP,vector
R12814	T16249	T16255	punct	(,HOIP
R12815	T16250	T16255	compound	HOIP,HOIP
R12816	T16251	T16254	punct	-,+
R12817	T16252	T16254	punct	/,+
R12818	T16253	T16254	punct	-,+
R12819	T16254	T16255	compound	+,HOIP
R12820	T16255	T16248	appos	HOIP,HOIP
R12821	T16256	T16255	punct	),HOIP
R12822	T16257	T16206	punct	.,was
R12823	T16258	T16260	nsubjpass	Cells,activated
R12824	T16259	T16260	auxpass	were,activated
R12825	T16260	T16260	ROOT	activated,activated
R12826	T16261	T16260	prep	with,activated
R12827	T16262	T16264	amod	CD154-expressing,cells
R12828	T16263	T16264	compound	insect,cells
R12829	T16264	T16261	pobj	cells,with
R12830	T16265	T16260	prep	for,activated
R12831	T16266	T16267	det	the,times
R12832	T16267	T16265	pobj	times,for
R12833	T16268	T16260	conj	indicated,activated
R12834	T16269	T16260	punct	.,activated
R12835	T16270	T16277	prep	As,stimulated
R12836	T16271	T16273	det	a,control
R12837	T16272	T16273	amod	negative,control
R12838	T16273	T16270	pobj	control,As
R12839	T16274	T16277	punct	",",stimulated
R12840	T16275	T16277	nsubjpass	cells,stimulated
R12841	T16276	T16277	auxpass	were,stimulated
R12842	T16277	T16277	ROOT	stimulated,stimulated
R12843	T16278	T16277	prep	with,stimulated
R12844	T16279	T16280	amod	insect,cells
R12845	T16280	T16278	pobj	cells,with
R12846	T16281	T16280	acl	lacking,cells
R12847	T16282	T16281	dobj	CD154,lacking
R12848	T16283	T16282	punct	(,CD154
R12849	T16284	T16287	nummod	5,point
R12850	T16285	T16286	amod	minute,time
R12851	T16286	T16287	compound	time,point
R12852	T16287	T16282	appos	point,CD154
R12853	T16288	T16289	advmod	only,)
R12854	T16289	T16282	punct	),CD154
R12855	T16290	T16277	punct	.,stimulated
R12856	T16291	T16292	amod	Western,blots
R12857	T16292	T16297	nsubjpass	blots,probed
R12858	T16293	T16292	prep	of,blots
R12859	T16294	T16295	amod	whole-cell,lysates
R12860	T16295	T16293	pobj	lysates,of
R12861	T16296	T16297	auxpass	were,probed
R12862	T16297	T16297	ROOT	probed,probed
R12863	T16298	T16297	prep	with,probed
R12864	T16299	T16301	det	the,antibodies
R12865	T16300	T16301	amod	indicated,antibodies
R12866	T16301	T16298	pobj	antibodies,with
R12867	T16302	T16297	punct	.,probed
R12868	T16303	T16312	nmod	Phospho-IκBα,blots
R12869	T16304	T16305	punct	(,pIκBα
R12870	T16305	T16303	appos	pIκBα,Phospho-IκBα
R12871	T16306	T16305	punct	),pIκBα
R12872	T16307	T16303	cc	and,Phospho-IκBα
R12873	T16308	T16303	conj	phospho-JNK,Phospho-IκBα
R12874	T16309	T16308	punct	(,phospho-JNK
R12875	T16310	T16308	appos	pJNK,phospho-JNK
R12876	T16311	T16308	punct	),phospho-JNK
R12877	T16312	T16314	nsubjpass	blots,stripped
R12878	T16313	T16314	auxpass	were,stripped
R12879	T16314	T16314	ROOT	stripped,stripped
R12880	T16315	T16314	cc	and,stripped
R12881	T16316	T16314	conj	reprobed,stripped
R12882	T16317	T16316	prep	for,reprobed
R12883	T16318	T16319	amod	total,IκBα
R12884	T16319	T16317	pobj	IκBα,for
R12885	T16320	T16316	cc	and,reprobed
R12886	T16321	T16322	compound	total,JNK
R12887	T16322	T16316	conj	JNK,reprobed
R12888	T16323	T16322	punct	",",JNK
R12889	T16324	T16322	conj	respectively,JNK
R12890	T16325	T16328	punct	(,recognize
R12891	T16326	T16327	amod	anti-JNK,antibodies
R12892	T16327	T16328	nsubj	antibodies,recognize
R12893	T16328	T16322	parataxis	recognize,JNK
R12894	T16329	T16328	dobj	p46,recognize
R12895	T16330	T16329	cc	and,p46
R12896	T16331	T16329	conj	p54,p46
R12897	T16332	T16322	conj	isoforms,JNK
R12898	T16333	T16322	punct	),JNK
R12899	T16334	T16314	punct	.,stripped
R12900	T16335	T16336	compound	IκBα,blots
R12901	T16336	T16339	nsubjpass	blots,reprobed
R12902	T16337	T16339	auxpass	were,reprobed
R12903	T16338	T16337	advmod	also,were
R12904	T16339	T16339	ROOT	reprobed,reprobed
R12905	T16340	T16339	prep	for,reprobed
R12906	T16341	T16343	nsubj	actin,demonstrate
R12907	T16342	T16343	aux	to,demonstrate
R12908	T16343	T16339	advcl	demonstrate,reprobed
R12909	T16344	T16345	amod	equal,lane
R12910	T16345	T16346	compound	lane,loading
R12911	T16346	T16343	dobj	loading,demonstrate
R12912	T16347	T16339	punct	.,reprobed
R12913	T16348	T16349	amod	Molecular,weights
R12914	T16349	T16351	nsubjpass	weights,indicated
R12915	T16350	T16351	auxpass	are,indicated
R12916	T16351	T16351	ROOT	indicated,indicated
R12917	T16352	T16351	prep	at,indicated
R12918	T16353	T16352	pobj	right,at
R12919	T16354	T16351	punct	.,indicated
R12920	T16355	T16356	amod	Similar,results
R12921	T16356	T16358	nsubjpass	results,obtained
R12922	T16357	T16358	auxpass	were,obtained
R12923	T16358	T16358	ROOT	obtained,obtained
R12924	T16359	T16358	prep	in,obtained
R12925	T16360	T16362	det	a,experiment
R12926	T16361	T16362	amod	second,experiment
R12927	T16362	T16359	pobj	experiment,in
R12928	T16363	T16359	cc	and,in
R12929	T16364	T16358	prep	in,obtained
R12930	T16365	T16367	nummod	two,experiments
R12931	T16366	T16367	amod	additional,experiments
R12932	T16367	T16364	pobj	experiments,in
R12933	T16368	T16367	prep	with,experiments
R12934	T16369	T16372	det	a,clone
R12935	T16370	T16372	amod	second,clone
R12936	T16371	T16372	amod	HOIP-deficient,clone
R12937	T16372	T16368	pobj	clone,with
R12938	T16373	T16358	punct	.,obtained

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T6097	40-43	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T6098	411-414	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T6099	1299-1302	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T6100	1358-1361	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T6101	1465-1468	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T6102	1507-1510	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T6103	224-233	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T6104	646-653	http://purl.obolibrary.org/obo/GO_0023052	denotes	signals
T6105	383-406	http://purl.obolibrary.org/obo/GO_0051092	denotes	activation of the NF-κB
T6106	1483-1502	http://purl.obolibrary.org/obo/GO_0051092	denotes	activation of NF-κB
T6107	442-457	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcriptional
T6108	748-763	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T6109	1082-1097	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T6110	1425-1440	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T6111	748-770	http://purl.obolibrary.org/obo/GO_0007252	denotes	phosphorylation of IκB
T6112	807-810	http://purl.obolibrary.org/obo/GO_0008384	denotes	IKK
T6113	933-936	http://purl.obolibrary.org/obo/GO_0008384	denotes	IKK
T6114	864-876	http://purl.obolibrary.org/obo/GO_0051235	denotes	sequestering
T6115	957-984	http://purl.obolibrary.org/obo/GO_0016567	denotes	proteins for ubiquitination
T6116	989-1000	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T6117	1102-1113	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T6118	1051-1066	http://purl.obolibrary.org/obo/GO_0010467	denotes	gene expression
T6119	1274-1298	http://purl.obolibrary.org/obo/GO_0034199	denotes	activated protein kinase
T6120	1274-1298	http://purl.obolibrary.org/obo/GO_0032147	denotes	activated protein kinase
T6121	1274-1298	http://purl.obolibrary.org/obo/GO_0030295	denotes	activated protein kinase
T6122	1274-1298	http://purl.obolibrary.org/obo/GO_0032111	denotes	activated protein kinase
T16565	1716-1735	http://purl.obolibrary.org/obo/GO_0051092	denotes	activation of NF-κB
T16566	1740-1743	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T16567	2344-2347	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T16568	2413-2416	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T16569	2437-2440	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T16570	1796-1805	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T6123	40-43	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T6124	411-414	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T6125	1299-1302	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T6126	1358-1361	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T6127	1465-1468	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T6128	1507-1510	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T6129	323-329	http://purl.obolibrary.org/obo/GO_0005488	denotes	ligand
T6130	674-682	http://purl.obolibrary.org/obo/GO_0003823	denotes	antibody
T6131	807-810	http://purl.obolibrary.org/obo/GO_0008384	denotes	IKK
T6132	933-936	http://purl.obolibrary.org/obo/GO_0008384	denotes	IKK
T6133	1274-1298	http://purl.obolibrary.org/obo/GO_0030295	denotes	activated protein kinase
T16571	1740-1743	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T16572	2344-2347	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T16573	2413-2416	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T16574	2437-2440	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T16575	2299-2309	http://purl.obolibrary.org/obo/GO_0003823	denotes	antibodies
T16576	2441-2451	http://purl.obolibrary.org/obo/GO_0003823	denotes	antibodies

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T6145	674-682	http://purl.obolibrary.org/obo/GO_0042571	denotes	antibody
T6146	798-810	http://purl.obolibrary.org/obo/GO_0008385	denotes	complex (IKK
T6147	933-944	http://purl.obolibrary.org/obo/GO_0008385	denotes	IKK complex
T6148	899-908	http://purl.obolibrary.org/obo/GO_0005737	denotes	cytoplasm
T6149	1030-1037	http://purl.obolibrary.org/obo/GO_0005634	denotes	nucleus
T16577	1775-1780	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T16578	1838-1843	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T16579	1885-1890	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T16580	1972-1977	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T16581	2096-2101	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T16582	2150-2155	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T16583	2184-2189	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T16584	2255-2259	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T16585	2299-2309	http://purl.obolibrary.org/obo/GO_0019815	denotes	antibodies
T16586	2441-2451	http://purl.obolibrary.org/obo/GO_0019815	denotes	antibodies
T16587	2299-2309	http://purl.obolibrary.org/obo/GO_0042571	denotes	antibodies
T16588	2441-2451	http://purl.obolibrary.org/obo/GO_0042571	denotes	antibodies
T6134	163-168	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6135	300-305	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6136	355-360	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6137	824-829	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6138	1140-1145	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6139	1217-1222	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6140	1391-1396	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6141	1533-1538	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6142	1609-1614	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6143	492-507	http://purl.obolibrary.org/obo/GO_0009986	denotes	Cell-associated
T6144	674-682	http://purl.obolibrary.org/obo/GO_0019815	denotes	antibody

sentences

Id	Subject	Object	Predicate	Lexical cue
T5496	0-54	Sentence	denotes	HOIP mediates CD40-stimulated NF-κB and JNK activation
T5497	55-169	Sentence	denotes	The results described above show that HOIP plays an important role in CD40-mediated effector functions of B cells.
T5498	170-234	Sentence	denotes	It follows that HOIP is likely a key mediator of CD40 signaling.
T5499	235-491	Sentence	denotes	To test this hypothesis, we stimulated A20.2J and HOIP-deficient cells with CD154 (CD40 ligand) expressed by HI5 insect cells [7], [8] and measured activation of the NF-κB and JNK pathways, two of the major transcriptional regulators activated by CD40 [4].
T5500	492-683	Sentence	denotes	Cell-associated CD154 was used as the stimulus in these experiments as it typically provides more robust, and therefore more readily detected, activation signals than does anti-CD40 antibody.
T5501	684-812	Sentence	denotes	Activation of the canonical NF-κB pathway is initiated with the phosphorylation of IκB proteins by the IκB kinase complex (IKK).
T5502	813-909	Sentence	denotes	In resting cells, IκB proteins are responsible for sequestering NF-κB subunits in the cytoplasm.
T5503	910-1067	Sentence	denotes	Phosphorylation by the IKK complex targets IκB proteins for ubiquitination and degradation, allowing NF-κB to enter the nucleus and activate gene expression.
T5504	1068-1232	Sentence	denotes	CD40-mediated phosphorylation and degradation of IκBα in HOIP-deficient cells was dramatically impaired relative to that observed in parental A20.2J cells (Fig. 4).
T5505	1233-1343	Sentence	denotes	We also assayed activation of the stress-activated protein kinase JNK in response to CD40 engagement (Fig. 4).
T5506	1344-1469	Sentence	denotes	CD40-mediated JNK activation in HOIP-deficient cells was impaired as measured by phosphorylation of Thr183 and Tyr185 in JNK.
T5507	1470-1658	Sentence	denotes	CD40-induced activation of NF-κB and JNK in HOIP-reconstituted cells was normal, demonstrating that the defects observed in gene-deficient cells were due to the absence of HOIP expression.
T16183	1703-1781	Sentence	denotes	CD40-induced activation of NF-κB and JNK is defective in HOIP-deficient cells.
T16184	1782-2045	Sentence	denotes	CD40-mediated signaling was defective in HOIP-deficient cells (HOIP-/- + pMIP), but intact in parental cells transduced with an empty retroviral vector (A20.2J + pMIP) and in HOIP-deficient cells transduced with a retroviral vector encoding HOIP (HOIP-/- + HOIP).
T16185	2046-2126	Sentence	denotes	Cells were activated with CD154-expressing insect cells for the times indicated.
T16186	2127-2231	Sentence	denotes	As a negative control, cells were stimulated with insect cells lacking CD154 (5 minute time point only).
T16187	2232-2310	Sentence	denotes	Western blots of whole-cell lysates were probed with the indicated antibodies.
T16188	2311-2484	Sentence	denotes	Phospho-IκBα (pIκBα) and phospho-JNK (pJNK) blots were stripped and reprobed for total IκBα and total JNK, respectively (anti-JNK antibodies recognize p46 and p54 isoforms).
T16189	2485-2559	Sentence	denotes	IκBα blots were also reprobed for actin to demonstrate equal lane loading.
T16190	2560-2601	Sentence	denotes	Molecular weights are indicated at right.
T16191	2602-2724	Sentence	denotes	Similar results were obtained in a second experiment and in two additional experiments with a second HOIP-deficient clone.
T86	0-54	Sentence	denotes	HOIP mediates CD40-stimulated NF-κB and JNK activation
T87	55-169	Sentence	denotes	The results described above show that HOIP plays an important role in CD40-mediated effector functions of B cells.
T88	170-234	Sentence	denotes	It follows that HOIP is likely a key mediator of CD40 signaling.
T89	235-491	Sentence	denotes	To test this hypothesis, we stimulated A20.2J and HOIP-deficient cells with CD154 (CD40 ligand) expressed by HI5 insect cells [7], [8] and measured activation of the NF-κB and JNK pathways, two of the major transcriptional regulators activated by CD40 [4].
T90	492-683	Sentence	denotes	Cell-associated CD154 was used as the stimulus in these experiments as it typically provides more robust, and therefore more readily detected, activation signals than does anti-CD40 antibody.
T91	684-812	Sentence	denotes	Activation of the canonical NF-κB pathway is initiated with the phosphorylation of IκB proteins by the IκB kinase complex (IKK).
T92	813-909	Sentence	denotes	In resting cells, IκB proteins are responsible for sequestering NF-κB subunits in the cytoplasm.
T93	910-1067	Sentence	denotes	Phosphorylation by the IKK complex targets IκB proteins for ubiquitination and degradation, allowing NF-κB to enter the nucleus and activate gene expression.
T94	1068-1232	Sentence	denotes	CD40-mediated phosphorylation and degradation of IκBα in HOIP-deficient cells was dramatically impaired relative to that observed in parental A20.2J cells (Fig. 4).
T95	1233-1343	Sentence	denotes	We also assayed activation of the stress-activated protein kinase JNK in response to CD40 engagement (Fig. 4).
T96	1344-1469	Sentence	denotes	CD40-mediated JNK activation in HOIP-deficient cells was impaired as measured by phosphorylation of Thr183 and Tyr185 in JNK.
T97	1470-1658	Sentence	denotes	CD40-induced activation of NF-κB and JNK in HOIP-reconstituted cells was normal, demonstrating that the defects observed in gene-deficient cells were due to the absence of HOIP expression.
T98	1659-1781	Sentence	denotes	10.1371/journal.pone.0023061.g004 Figure 4 CD40-induced activation of NF-κB and JNK is defective in HOIP-deficient cells.
T99	1782-2045	Sentence	denotes	CD40-mediated signaling was defective in HOIP-deficient cells (HOIP-/- + pMIP), but intact in parental cells transduced with an empty retroviral vector (A20.2J + pMIP) and in HOIP-deficient cells transduced with a retroviral vector encoding HOIP (HOIP-/- + HOIP).
T100	2046-2126	Sentence	denotes	Cells were activated with CD154-expressing insect cells for the times indicated.
T101	2127-2231	Sentence	denotes	As a negative control, cells were stimulated with insect cells lacking CD154 (5 minute time point only).
T102	2232-2310	Sentence	denotes	Western blots of whole-cell lysates were probed with the indicated antibodies.
T103	2311-2484	Sentence	denotes	Phospho-IκBα (pIκBα) and phospho-JNK (pJNK) blots were stripped and reprobed for total IκBα and total JNK, respectively (anti-JNK antibodies recognize p46 and p54 isoforms).
T104	2485-2559	Sentence	denotes	IκBα blots were also reprobed for actin to demonstrate equal lane loading.
T105	2560-2601	Sentence	denotes	Molecular weights are indicated at right.
T106	2602-2724	Sentence	denotes	Similar results were obtained in a second experiment and in two additional experiments with a second HOIP-deficient clone.

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T6055	0-4	Q96EP0	denotes	HOIP
T6056	14-18	P25942	denotes	CD40
T6057	93-97	Q96EP0	denotes	HOIP
T6058	125-129	P25942	denotes	CD40
T6059	186-190	Q96EP0	denotes	HOIP
T6060	219-223	P25942	denotes	CD40
T6061	274-277	P21580	denotes	A20
T6062	285-289	Q96EP0	denotes	HOIP
T6063	311-316	P29965	denotes	CD154
T6064	318-322	P25942	denotes	CD40
T6065	318-329	P29965	denotes	CD40 ligand
T6066	482-486	P25942	denotes	CD40
T6067	508-513	P29965	denotes	CD154
T6068	669-673	P25942	denotes	CD40
T6069	787-797	O15111	denotes	IκB kinase
T6070	787-797	Q60680-2	denotes	IκB kinase
T6071	1068-1072	P25942	denotes	CD40
T6072	1117-1121	P25963	denotes	IκBα
T6073	1125-1129	Q96EP0	denotes	HOIP
T6074	1172-1180	Q04864	denotes	relative
T6075	1210-1213	P21580	denotes	A20
T6076	1267-1298	O15264	denotes	stress-activated protein kinase
T6077	1267-1298	P53778	denotes	stress-activated protein kinase
T6078	1267-1302	P53779	denotes	stress-activated protein kinase JNK
T6079	1318-1322	P25942	denotes	CD40
T6080	1344-1348	P25942	denotes	CD40
T6081	1376-1380	Q96EP0	denotes	HOIP
T6082	1470-1474	P25942	denotes	CD40
T6083	1514-1518	Q96EP0	denotes	HOIP
T6084	1642-1646	Q96EP0	denotes	HOIP
T16539	1703-1707	P25942	denotes	CD40
T16540	1760-1764	Q96EP0	denotes	HOIP
T16541	1782-1786	P25942	denotes	CD40
T16542	1823-1827	Q96EP0	denotes	HOIP
T16543	1845-1849	Q96EP0	denotes	HOIP
T16544	1935-1938	P21580	denotes	A20
T16545	1957-1961	Q96EP0	denotes	HOIP
T16546	2023-2027	Q96EP0	denotes	HOIP
T16547	2029-2033	Q96EP0	denotes	HOIP
T16548	2039-2043	Q96EP0	denotes	HOIP
T16549	2072-2077	P29965	denotes	CD154
T16550	2198-2203	P29965	denotes	CD154
T16551	2319-2323	P25963	denotes	IκBα
T16552	2398-2402	P25963	denotes	IκBα
T16553	2470-2473	Q13451	denotes	p54
T16554	2485-2489	P25963	denotes	IκBα
T16555	2703-2707	Q96EP0	denotes	HOIP

test2

Id	Subject	Object	Predicate	Lexical cue	Negation
T5423	0-4	Protein	denotes	HOIP
T5424	14-18	Protein	denotes	CD40
T5425	93-97	Protein	denotes	HOIP
T5426	125-129	Protein	denotes	CD40
T5427	186-190	Protein	denotes	HOIP
T5428	219-223	Protein	denotes	CD40
T5429	290-299	Negative_regulation	denotes	deficient
T5430	311-316	Protein	denotes	CD154
T5431	318-329	Protein	denotes	CD40 ligand
T5432	331-340	Gene_expression	denotes	expressed
T5433	482-486	Protein	denotes	CD40
T5434	508-513	Protein	denotes	CD154
T5435	877-891	Protein	denotes	NF-κB subunits
T5436	910-925	Phosphorylation	denotes	Phosphorylation
T5437	989-1000	Protein_catabolism	denotes	degradation	true
T5438	1002-1010	Positive_regulation	denotes	allowing
T5439	1030-1037	Entity	denotes	nucleus
T5440	1068-1072	Protein	denotes	CD40
T5441	1073-1081	Positive_regulation	denotes	mediated
T5442	1082-1097	Phosphorylation	denotes	phosphorylation
T5443	1102-1113	Protein_catabolism	denotes	degradation
T5444	1117-1121	Protein	denotes	IκBα
T5445	1125-1129	Protein	denotes	HOIP
T5446	1130-1139	Negative_regulation	denotes	deficient
T5447	1163-1171	Negative_regulation	denotes	impaired
T5448	1318-1322	Protein	denotes	CD40
T5449	1323-1333	Binding	denotes	engagement
T5450	1344-1348	Protein	denotes	CD40
T5451	1376-1380	Protein	denotes	HOIP
T5452	1381-1390	Negative_regulation	denotes	deficient
T5453	1401-1409	Negative_regulation	denotes	impaired
T5454	1470-1474	Protein	denotes	CD40
T5455	1514-1518	Protein	denotes	HOIP
T5456	1519-1532	Positive_regulation	denotes	reconstituted
T5457	1599-1608	Negative_regulation	denotes	deficient
T5458	1631-1638	Negative_regulation	denotes	absence
T5459	1642-1646	Protein	denotes	HOIP
T5460	1647-1657	Gene_expression	denotes	expression
T16141	1703-1707	Protein	denotes	CD40
T16142	1760-1764	Protein	denotes	HOIP
T16143	1765-1774	Negative_regulation	denotes	deficient
T16144	1782-1786	Protein	denotes	CD40
T16145	1823-1827	Protein	denotes	HOIP
T16146	1828-1837	Negative_regulation	denotes	deficient
T16147	1957-1961	Protein	denotes	HOIP
T16148	1962-1971	Negative_regulation	denotes	deficient
T16149	2023-2027	Protein	denotes	HOIP
T16150	2029-2033	Protein	denotes	HOIP
T16151	2039-2043	Protein	denotes	HOIP
T16152	2072-2077	Protein	denotes	CD154
T16153	2078-2088	Gene_expression	denotes	expressing
T16154	2190-2197	Negative_regulation	denotes	lacking
T16155	2198-2203	Protein	denotes	CD154
T16156	2311-2323	Protein	denotes	Phospho-IκBα
T16157	2325-2330	Protein	denotes	pIκBα
T16158	2398-2402	Protein	denotes	IκBα
T16159	2485-2489	Protein	denotes	IκBα
T16160	2703-2707	Protein	denotes	HOIP
T16161	2708-2717	Negative_regulation	denotes	deficient
R4169	T5430	T5432	themeOf	CD154,expressed
R4170	T5431	T5430	equivalentTo	CD40 ligand,CD154
R4171	T5436	T5438	causeOf	Phosphorylation,allowing
R4172	T5440	T5441	causeOf	CD40,mediated
R4173	T5441	T5447	themeOf	mediated,impaired
R4174	T5442	T5441	themeOf	phosphorylation,mediated
R4175	T5443	T5441	themeOf	degradation,mediated
R4176	T5444	T5443	themeOf	IκBα,degradation
R4177	T5444	T5442	themeOf	IκBα,phosphorylation
R4178	T5445	T5446	themeOf	HOIP,deficient
R4179	T5448	T5449	themeOf	CD40,engagement
R4180	T5451	T5452	themeOf	HOIP,deficient
R4181	T5455	T5456	themeOf	HOIP,reconstituted
R4182	T5459	T5460	themeOf	HOIP,expression
R4183	T5460	T5458	themeOf	expression,absence
R12742	T16142	T16143	themeOf	HOIP,deficient
R12743	T16145	T16146	themeOf	HOIP,deficient
R12744	T16147	T16148	themeOf	HOIP,deficient
R12745	T16150	T16149	equivalentTo	HOIP,HOIP
R12746	T16152	T16153	themeOf	CD154,expressing
R12747	T16155	T16154	themeOf	CD154,lacking
R12748	T16157	T16156	equivalentTo	pIκBα,Phospho-IκBα
R12749	T16160	T16161	themeOf	HOIP,deficient

PMC:3148254 / 12486-15213 JSONTXT

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PMC:3148254 / 12486-15213 JSON TXT