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bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue
T84 0-4 Protein denotes CD40
T85 149-159 Binding denotes engagement
T86 163-167 Protein denotes CD40
T87 175-181 Protein denotes ligand
T88 182-187 Protein denotes CD154
T89 297-301 Protein denotes CD40
T90 415-419 Protein denotes CD40
T91 420-430 Binding denotes engagement
T92 623-627 Protein denotes CD40
T93 871-876 Protein denotes TRAF2
T94 877-885 Positive_regulation denotes mediates
T95 886-897 Binding denotes recruitment
T96 901-928 Protein denotes HOIL-1L-interacting protein
T97 930-934 Protein denotes HOIP
T98 943-961 Entity denotes cytoplasmic domain
T99 965-969 Protein denotes CD40
T100 987-991 Protein denotes HOIP
T101 1010-1014 Protein denotes CD40
T102 1059-1063 Protein denotes HOIP
T103 1067-1071 Protein denotes CD40
T104 1150-1159 Negative_regulation denotes deficient
T105 1163-1167 Protein denotes HOIP
T106 1187-1191 Protein denotes CD40
T107 1192-1199 Positive_regulation denotes induced
T108 1200-1212 Positive_regulation denotes upregulation
T109 1216-1220 Protein denotes CD80
T110 1290-1299 Negative_regulation denotes defective
T111 1303-1307 Protein denotes HOIP
T112 1308-1317 Negative_regulation denotes deficient
T113 1348-1352 Protein denotes CD40
T114 1498-1502 Protein denotes HOIP
T115 1503-1512 Negative_regulation denotes deficient
T116 1575-1586 Positive_regulation denotes Restoration
T117 1590-1594 Protein denotes HOIP
T118 1595-1605 Gene_expression denotes expression
T119 1686-1690 Protein denotes HOIP
T120 1717-1721 Protein denotes CD40
R39 T86 T85 themeOf CD40,engagement
R40 T88 T85 themeOf CD154,engagement
R41 T90 T91 themeOf CD40,engagement
R42 T93 T94 causeOf TRAF2,mediates
R43 T95 T94 themeOf recruitment,mediates
R44 T96 T95 themeOf HOIL-1L-interacting protein,recruitment
R45 T97 T96 equivalentTo HOIP,HOIL-1L-interacting protein
R46 T98 T99 partOf cytoplasmic domain,CD40
R47 T98 T95 themeOf cytoplasmic domain,recruitment
R48 T105 T104 themeOf HOIP,deficient
R49 T106 T107 causeOf CD40,induced
R50 T107 T110 themeOf induced,defective
R51 T108 T107 themeOf upregulation,induced
R52 T109 T108 themeOf CD80,upregulation
R53 T111 T112 themeOf HOIP,deficient
R54 T114 T115 themeOf HOIP,deficient
R55 T117 T118 themeOf HOIP,expression
R56 T118 T116 themeOf expression,Restoration

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T893 0-4 Protein denotes CD40
T894 163-167 Protein denotes CD40
T895 182-187 Protein denotes CD154
T896 149-159 Binding denotes engagement
T897 297-301 Protein denotes CD40
T898 415-419 Protein denotes CD40
T899 517-522 Protein denotes NF-κB
T900 524-556 Protein denotes stress-activated protein kinases
T901 420-430 Binding denotes engagement
T902 503-513 Positive_regulation denotes activation
T903 503-513 Positive_regulation denotes activation
T904 623-627 Protein denotes CD40
T905 718-722 Protein denotes CD40
T906 764-794 Protein denotes TNF receptor-associated factor
T907 796-800 Protein denotes TRAF
T908 852-856 Protein denotes TRAF
T909 871-876 Protein denotes TRAF2
T910 901-928 Protein denotes HOIL-1L-interacting protein
T911 930-934 Protein denotes HOIP
T912 965-969 Protein denotes CD40
T913 1010-1014 Protein denotes CD40
T914 955-961 Entity denotes domain
T915 886-897 Binding denotes recruitment
T916 886-897 Binding denotes recruitment
T917 886-897 Binding denotes recruitment
T918 886-897 Binding denotes recruitment
T919 1059-1063 Protein denotes HOIP
T920 1067-1071 Protein denotes CD40
T921 1187-1191 Protein denotes CD40
T922 1216-1220 Protein denotes CD80
T923 1239-1262 Protein denotes germline immunoglobulin
T924 1271-1284 Transcription denotes transcription
T925 1225-1235 Positive_regulation denotes activation
T926 1348-1352 Protein denotes CD40
T927 1376-1381 Protein denotes NF-κB
T928 1386-1398 Protein denotes c-Jun kinase
T929 1362-1372 Positive_regulation denotes activation
T930 1362-1372 Positive_regulation denotes activation
T931 1403-1411 Negative_regulation denotes impaired
T932 1403-1411 Negative_regulation denotes impaired
T933 1428-1447 Protein denotes IκB kinase proteins
T934 1455-1459 Protein denotes CD40
T935 1557-1562 Protein denotes NF-κB
T936 1413-1424 Binding denotes Recruitment
T937 1563-1573 Positive_regulation denotes activation
T938 1590-1594 Protein denotes HOIP
T939 1595-1605 Gene_expression denotes expression
T940 1717-1721 Protein denotes CD40
R653 T894 T896 themeOf CD40,engagement
R654 T898 T901 themeOf CD40,engagement
R655 T899 T902 themeOf NF-κB,activation
R656 T900 T903 themeOf stress-activated protein kinases,activation
R657 T910 T917 themeOf HOIL-1L-interacting protein,recruitment
R658 T911 T915 themeOf HOIP,recruitment
R659 T911 T918 themeOf HOIP,recruitment
R660 T912 T916 themeOf CD40,recruitment
R661 T912 T917 themeOf CD40,recruitment
R662 T912 T918 themeOf CD40,recruitment
R663 T912 T914 partOf CD40,domain
R664 T914 T915 Site domain,recruitment
R665 T914 T916 Site domain,recruitment
R666 T914 T917 Site domain,recruitment
R667 T914 T918 Site domain,recruitment
R668 T923 T924 themeOf germline immunoglobulin,transcription
R669 T924 T925 themeOf transcription,activation
R670 T926 T929 causeOf CD40,activation
R671 T926 T930 causeOf CD40,activation
R672 T927 T929 themeOf NF-κB,activation
R673 T928 T930 themeOf c-Jun kinase,activation
R674 T929 T931 themeOf activation,impaired
R675 T930 T932 themeOf activation,impaired
R676 T933 T936 themeOf IκB kinase proteins,Recruitment
R677 T934 T936 themeOf CD40,Recruitment
R678 T935 T937 themeOf NF-κB,activation
R679 T938 T939 themeOf HOIP,expression

events-check-again

Id Subject Object Predicate Lexical cue
T944 0-4 Protein denotes CD40
T945 149-159 Binding denotes engagement
T946 163-167 Protein denotes CD40
T947 175-181 Protein denotes ligand
T948 182-187 Protein denotes CD154
T949 297-301 Protein denotes CD40
T950 415-419 Protein denotes CD40
T951 420-430 Binding denotes engagement
T952 623-627 Protein denotes CD40
T953 871-876 Protein denotes TRAF2
T954 877-885 Positive_regulation denotes mediates
T955 886-897 Binding denotes recruitment
T956 901-928 Protein denotes HOIL-1L-interacting protein
T957 930-934 Protein denotes HOIP
T958 943-961 Entity denotes cytoplasmic domain
T959 965-969 Protein denotes CD40
T960 987-991 Protein denotes HOIP
T961 1010-1014 Protein denotes CD40
T962 1059-1063 Protein denotes HOIP
T963 1067-1071 Protein denotes CD40
T964 1150-1159 Negative_regulation denotes deficient
T965 1163-1167 Protein denotes HOIP
T966 1187-1191 Protein denotes CD40
T967 1192-1199 Positive_regulation denotes induced
T968 1200-1212 Positive_regulation denotes upregulation
T969 1216-1220 Protein denotes CD80
T970 1290-1299 Negative_regulation denotes defective
T971 1303-1307 Protein denotes HOIP
T972 1308-1317 Negative_regulation denotes deficient
T973 1348-1352 Protein denotes CD40
T974 1498-1502 Protein denotes HOIP
T975 1503-1512 Negative_regulation denotes deficient
T976 1575-1586 Positive_regulation denotes Restoration
T977 1590-1594 Protein denotes HOIP
T978 1595-1605 Gene_expression denotes expression
T979 1686-1690 Protein denotes HOIP
T980 1717-1721 Protein denotes CD40
R681 T946 T945 themeOf CD40,engagement
R682 T948 T945 themeOf CD154,engagement
R683 T950 T951 themeOf CD40,engagement
R684 T953 T954 causeOf TRAF2,mediates
R685 T955 T954 themeOf recruitment,mediates
R686 T956 T955 themeOf HOIL-1L-interacting protein,recruitment
R687 T957 T956 equivalentTo HOIP,HOIL-1L-interacting protein
R688 T958 T959 partOf cytoplasmic domain,CD40
R689 T958 T955 themeOf cytoplasmic domain,recruitment
R690 T965 T964 themeOf HOIP,deficient
R691 T966 T967 causeOf CD40,induced
R692 T967 T970 themeOf induced,defective
R693 T968 T967 themeOf upregulation,induced
R694 T969 T968 themeOf CD80,upregulation
R695 T971 T972 themeOf HOIP,deficient
R696 T974 T975 themeOf HOIP,deficient
R697 T977 T978 themeOf HOIP,expression
R698 T978 T976 themeOf expression,Restoration

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T436 0-4 NN denotes CD40
T437 5-7 VB denotes is
T438 8-9 DT denotes a
T439 10-14 NN denotes cell
T440 15-22 NN denotes surface
T441 23-31 NN denotes receptor
T442 32-41 JJ denotes important
T443 42-44 IN denotes in
T444 45-48 DT denotes the
T445 49-59 NN denotes activation
T446 60-62 IN denotes of
T447 63-81 JJ denotes antigen-presenting
T448 82-87 NN denotes cells
T449 88-94 IN denotes during
T450 95-101 JJ denotes immune
T451 102-111 NN denotes responses
T452 113-115 IN denotes In
T453 116-127 NN denotes macrophages
T454 128-131 CC denotes and
T455 132-141 JJ denotes dendritic
T456 142-147 NN denotes cells
T457 147-148 -COMMA- denotes ,
T458 149-159 NN denotes engagement
T459 160-162 IN denotes of
T460 163-167 NN denotes CD40
T461 168-170 IN denotes by
T462 171-174 PRP-DOLLAR- denotes its
T463 175-181 NN denotes ligand
T464 182-187 NN denotes CD154
T465 188-196 VB denotes provides
T466 197-204 NN denotes signals
T467 205-213 JJ denotes critical
T468 214-217 IN denotes for
T469 218-232 JJ denotes anti-microbial
T470 233-236 CC denotes and
T471 237-238 NN denotes T
T472 239-252 JJ denotes cell-mediated
T473 253-259 JJ denotes immune
T474 260-269 NN denotes responses
T475 269-270 -COMMA- denotes ,
T476 271-283 RB denotes respectively
T477 285-287 IN denotes In
T478 288-289 NN denotes B
T479 290-295 NN denotes cells
T480 295-296 -COMMA- denotes ,
T481 297-301 NN denotes CD40
T482 302-311 NN denotes signaling
T483 312-315 VB denotes has
T484 316-317 DT denotes a
T485 318-323 JJ denotes major
T486 324-328 NN denotes role
T487 329-331 IN denotes in
T488 332-342 VB denotes regulating
T489 343-347 NN denotes cell
T490 348-361 NN denotes proliferation
T491 361-362 -COMMA- denotes ,
T492 363-371 NN denotes antibody
T493 372-382 NN denotes production
T494 382-383 -COMMA- denotes ,
T495 384-387 CC denotes and
T496 388-394 NN denotes memory
T497 395-396 NN denotes B
T498 397-401 NN denotes cell
T499 402-413 NN denotes development
T500 415-419 NN denotes CD40
T501 420-430 NN denotes engagement
T502 431-438 VB denotes results
T503 439-441 IN denotes in
T504 442-445 DT denotes the
T505 446-455 NN denotes formation
T506 456-458 IN denotes of
T507 459-460 DT denotes a
T508 461-480 JJ denotes receptor-associated
T509 481-488 NN denotes complex
T510 489-493 WDT denotes that
T511 494-502 VB denotes mediates
T512 503-513 NN denotes activation
T513 514-516 IN denotes of
T514 517-522 NN denotes NF-κB
T515 522-523 -COMMA- denotes ,
T516 524-540 JJ denotes stress-activated
T517 541-548 NN denotes protein
T518 549-556 NN denotes kinases
T519 556-557 -COMMA- denotes ,
T520 558-561 CC denotes and
T521 562-567 JJ denotes other
T522 568-577 VB denotes signaling
T523 578-587 NN denotes molecules
T524 589-596 RB denotes However
T525 596-597 -COMMA- denotes ,
T526 598-601 DT denotes the
T527 602-612 NN denotes mechanisms
T528 613-617 WDT denotes that
T529 618-622 VB denotes link
T530 623-627 NN denotes CD40
T531 628-630 TO denotes to
T532 631-636 DT denotes these
T533 637-646 NN denotes signaling
T534 647-653 NN denotes events
T535 654-658 VB denotes have
T536 659-663 VB denotes been
T537 664-668 RB denotes only
T538 669-678 RB denotes partially
T539 679-692 VB denotes characterized
T540 694-699 VB denotes Known
T541 700-710 NN denotes components
T542 711-713 IN denotes of
T543 714-717 DT denotes the
T544 718-722 NN denotes CD40
T545 723-732 NN denotes signaling
T546 733-740 NN denotes complex
T547 741-748 VB denotes include
T548 749-756 NN denotes members
T549 757-759 IN denotes of
T550 760-763 DT denotes the
T551 764-767 NN denotes TNF
T552 768-787 JJ denotes receptor-associated
T553 788-794 NN denotes factor
T554 795-796 -LRB- denotes (
T555 796-800 NN denotes TRAF
T556 800-801 -RRB- denotes )
T557 802-808 NN denotes family
T558 809-811 IN denotes of
T559 812-820 NN denotes proteins
T560 822-824 PRP denotes We
T561 825-835 RB denotes previously
T562 836-842 VB denotes showed
T563 843-847 IN denotes that
T564 848-851 DT denotes the
T565 852-856 NN denotes TRAF
T566 857-863 NN denotes family
T567 864-870 NN denotes member
T568 871-876 NN denotes TRAF2
T569 877-885 VB denotes mediates
T570 886-897 NN denotes recruitment
T571 898-900 IN denotes of
T572 901-920 JJ denotes HOIL-1L-interacting
T573 921-928 NN denotes protein
T574 929-930 -LRB- denotes (
T575 930-934 NN denotes HOIP
T576 934-935 -RRB- denotes )
T577 936-938 TO denotes to
T578 939-942 DT denotes the
T579 943-954 JJ denotes cytoplasmic
T580 955-961 NN denotes domain
T581 962-964 IN denotes of
T582 965-969 NN denotes CD40
T583 969-970 -COMMA- denotes ,
T584 971-981 VB denotes suggesting
T585 982-986 IN denotes that
T586 987-991 NN denotes HOIP
T587 992-995 VB denotes has
T588 996-997 DT denotes a
T589 998-1002 NN denotes role
T590 1003-1005 IN denotes in
T591 1006-1009 DT denotes the
T592 1010-1014 NN denotes CD40
T593 1015-1024 NN denotes signaling
T594 1025-1032 NN denotes pathway
T595 1034-1036 TO denotes To
T596 1037-1046 VB denotes determine
T597 1047-1050 DT denotes the
T598 1051-1055 NN denotes role
T599 1056-1058 IN denotes of
T600 1059-1063 NN denotes HOIP
T601 1064-1066 IN denotes in
T602 1067-1071 NN denotes CD40
T603 1072-1081 NN denotes signaling
T604 1081-1082 -COMMA- denotes ,
T605 1083-1085 PRP denotes we
T606 1086-1090 VB denotes used
T607 1091-1098 JJ denotes somatic
T608 1099-1103 NN denotes cell
T609 1104-1108 NN denotes gene
T610 1109-1118 VB denotes targeting
T611 1119-1121 TO denotes to
T612 1122-1130 VB denotes generate
T613 1131-1136 NN denotes mouse
T614 1137-1138 NN denotes B
T615 1139-1143 NN denotes cell
T616 1144-1149 NN denotes lines
T617 1150-1159 JJ denotes deficient
T618 1160-1162 IN denotes in
T619 1163-1167 NN denotes HOIP
T620 1169-1171 PRP denotes We
T621 1172-1177 VB denotes found
T622 1178-1182 IN denotes that
T623 1183-1186 DT denotes the
T624 1187-1199 JJ denotes CD40-induced
T625 1200-1212 NN denotes upregulation
T626 1213-1215 IN denotes of
T627 1216-1220 NN denotes CD80
T628 1221-1224 CC denotes and
T629 1225-1235 NN denotes activation
T630 1236-1238 IN denotes of
T631 1239-1247 NN denotes germline
T632 1248-1262 NN denotes immunoglobulin
T633 1263-1270 NN denotes epsilon
T634 1271-1284 NN denotes transcription
T635 1285-1289 VB denotes were
T636 1290-1299 JJ denotes defective
T637 1300-1302 IN denotes in
T638 1303-1317 JJ denotes HOIP-deficient
T639 1318-1323 NN denotes cells
T640 1325-1327 PRP denotes We
T641 1328-1332 RB denotes also
T642 1333-1338 VB denotes found
T643 1339-1343 IN denotes that
T644 1344-1347 DT denotes the
T645 1348-1361 JJ denotes CD40-mediated
T646 1362-1372 NN denotes activation
T647 1373-1375 IN denotes of
T648 1376-1381 NN denotes NF-κB
T649 1382-1385 CC denotes and
T650 1386-1391 NN denotes c-Jun
T651 1392-1398 NN denotes kinase
T652 1399-1402 VB denotes was
T653 1403-1411 JJ denotes impaired
T654 1413-1424 NN denotes Recruitment
T655 1425-1427 IN denotes of
T656 1428-1431 NN denotes IκB
T657 1432-1438 NN denotes kinase
T658 1439-1447 NN denotes proteins
T659 1448-1450 TO denotes to
T660 1451-1454 DT denotes the
T661 1455-1459 NN denotes CD40
T662 1460-1469 NN denotes signaling
T663 1470-1477 NN denotes complex
T664 1478-1481 VB denotes was
T665 1482-1494 JJ denotes undetectable
T666 1495-1497 IN denotes in
T667 1498-1512 JJ denotes HOIP-deficient
T668 1513-1518 NN denotes cells
T669 1518-1519 -COMMA- denotes ,
T670 1520-1531 RB denotes potentially
T671 1532-1542 VB denotes explaining
T672 1543-1546 DT denotes the
T674 1554-1556 IN denotes in
T675 1557-1562 NN denotes NF-κB
T676 1563-1573 NN denotes activation
T677 1575-1586 NN denotes Restoration
T678 1587-1589 IN denotes of
T679 1590-1594 NN denotes HOIP
T680 1595-1605 NN denotes expression
T681 1606-1614 VB denotes reversed
T682 1615-1618 DT denotes the
T683 1619-1626 NN denotes defects
T684 1627-1629 IN denotes in
T685 1630-1638 JJ denotes cellular
T686 1639-1649 NN denotes activation
T687 1650-1653 CC denotes and
T688 1654-1663 NN denotes signaling
T689 1665-1670 DT denotes These
T690 1671-1678 NN denotes results
T691 1679-1685 VB denotes reveal
T692 1686-1690 NN denotes HOIP
T693 1691-1693 IN denotes as
T694 1694-1695 DT denotes a
T695 1696-1699 JJ denotes key
T696 1700-1709 NN denotes component
T697 1710-1712 IN denotes of
T698 1713-1716 DT denotes the
T699 1717-1721 NN denotes CD40
T700 1722-1731 NN denotes signaling
T701 1732-1739 NN denotes pathway
T673 1547-1553 NN denotes defect
R358 T436 T437 arg1Of CD40,is
R359 T441 T437 arg2Of receptor,is
R360 T441 T438 arg1Of receptor,a
R361 T441 T439 arg1Of receptor,cell
R362 T441 T440 arg1Of receptor,surface
R363 T441 T442 arg1Of receptor,important
R364 T442 T443 arg1Of important,in
R365 T445 T443 arg2Of activation,in
R366 T445 T444 arg1Of activation,the
R367 T445 T446 arg1Of activation,of
R368 T445 T449 arg1Of activation,during
R369 T448 T446 arg2Of cells,of
R370 T448 T447 arg1Of cells,antigen-presenting
R371 T451 T449 arg2Of responses,during
R372 T451 T450 arg1Of responses,immune
R373 T453 T454 arg1Of macrophages,and
R374 T454 T452 arg2Of and,In
R375 T456 T454 arg2Of cells,and
R376 T456 T455 arg1Of cells,dendritic
R377 T458 T459 arg1Of engagement,of
R378 T458 T461 arg1Of engagement,by
R379 T458 T465 arg1Of engagement,provides
R380 T460 T459 arg2Of CD40,of
R381 T464 T461 arg2Of CD154,by
R382 T464 T462 arg1Of CD154,its
R383 T464 T463 arg1Of CD154,ligand
R384 T465 T452 arg1Of provides,In
R385 T465 T457 arg1Of provides,","
R386 T465 T475 arg1Of provides,","
R387 T465 T476 arg1Of provides,respectively
R388 T466 T465 arg2Of signals,provides
R389 T466 T467 arg1Of signals,critical
R390 T467 T468 arg1Of critical,for
R391 T469 T470 arg1Of anti-microbial,and
R392 T472 T470 arg2Of cell-mediated,and
R393 T472 T471 arg1Of cell-mediated,T
R394 T474 T468 arg2Of responses,for
R395 T474 T469 arg1Of responses,anti-microbial
R396 T474 T472 arg1Of responses,cell-mediated
R397 T474 T473 arg1Of responses,immune
R398 T479 T477 arg2Of cells,In
R399 T479 T478 arg1Of cells,B
R400 T482 T481 arg1Of signaling,CD40
R401 T482 T483 arg1Of signaling,has
R402 T483 T477 arg1Of has,In
R403 T483 T480 arg1Of has,","
R404 T486 T483 arg2Of role,has
R405 T486 T484 arg1Of role,a
R406 T486 T485 arg1Of role,major
R407 T486 T487 arg1Of role,in
R408 T488 T487 arg2Of regulating,in
R409 T490 T489 arg1Of proliferation,cell
R410 T490 T491 arg1Of proliferation,","
R411 T491 T495 arg1Of ",",and
R412 T493 T491 arg2Of production,","
R413 T493 T492 arg1Of production,antibody
R414 T495 T488 arg2Of and,regulating
R415 T495 T494 arg1Of and,","
R416 T499 T495 arg2Of development,and
R417 T499 T496 arg1Of development,memory
R418 T499 T497 arg1Of development,B
R419 T499 T498 arg1Of development,cell
R420 T501 T500 arg1Of engagement,CD40
R421 T501 T502 arg1Of engagement,results
R422 T502 T503 arg1Of results,in
R423 T505 T503 arg2Of formation,in
R424 T505 T504 arg1Of formation,the
R425 T505 T506 arg1Of formation,of
R426 T505 T510 arg1Of formation,that
R427 T505 T511 arg1Of formation,mediates
R428 T509 T506 arg2Of complex,of
R429 T509 T507 arg1Of complex,a
R430 T509 T508 arg1Of complex,receptor-associated
R431 T512 T511 arg2Of activation,mediates
R432 T512 T513 arg1Of activation,of
R433 T514 T515 arg1Of NF-κB,","
R434 T515 T520 arg1Of ",",and
R435 T518 T515 arg2Of kinases,","
R436 T518 T516 arg1Of kinases,stress-activated
R437 T518 T517 arg1Of kinases,protein
R438 T520 T513 arg2Of and,of
R439 T520 T519 arg1Of and,","
R440 T523 T520 arg2Of molecules,and
R441 T523 T521 arg1Of molecules,other
R442 T523 T522 arg1Of molecules,signaling
R443 T527 T526 arg1Of mechanisms,the
R444 T527 T528 arg1Of mechanisms,that
R445 T527 T529 arg1Of mechanisms,link
R446 T527 T535 arg1Of mechanisms,have
R447 T527 T536 arg1Of mechanisms,been
R448 T527 T539 arg2Of mechanisms,characterized
R449 T529 T531 arg1Of link,to
R450 T530 T529 arg2Of CD40,link
R451 T534 T531 arg2Of events,to
R452 T534 T532 arg1Of events,these
R453 T534 T533 arg1Of events,signaling
R454 T538 T537 arg1Of partially,only
R455 T539 T524 arg1Of characterized,However
R456 T539 T525 arg1Of characterized,","
R457 T539 T535 arg2Of characterized,have
R458 T539 T536 arg2Of characterized,been
R459 T539 T538 arg1Of characterized,partially
R460 T541 T540 arg2Of components,Known
R461 T541 T542 arg1Of components,of
R462 T541 T547 arg1Of components,include
R463 T546 T542 arg2Of complex,of
R464 T546 T543 arg1Of complex,the
R465 T546 T544 arg1Of complex,CD40
R466 T546 T545 arg1Of complex,signaling
R467 T548 T547 arg2Of members,include
R468 T548 T549 arg1Of members,of
R469 T553 T551 arg1Of factor,TNF
R470 T553 T552 arg1Of factor,receptor-associated
R471 T553 T554 arg1Of factor,(
R472 T555 T554 arg2Of TRAF,(
R473 T556 T554 arg3Of ),(
R474 T557 T549 arg2Of family,of
R475 T557 T550 arg1Of family,the
R476 T557 T553 arg1Of family,factor
R477 T557 T558 arg1Of family,of
R478 T559 T558 arg2Of proteins,of
R479 T560 T562 arg1Of We,showed
R480 T562 T561 arg1Of showed,previously
R481 T568 T564 arg1Of TRAF2,the
R482 T568 T565 arg1Of TRAF2,TRAF
R483 T568 T566 arg1Of TRAF2,family
R484 T568 T567 arg1Of TRAF2,member
R485 T568 T569 arg1Of TRAF2,mediates
R486 T569 T562 arg2Of mediates,showed
R487 T569 T563 arg1Of mediates,that
R488 T569 T583 arg1Of mediates,","
R489 T570 T569 arg2Of recruitment,mediates
R490 T570 T571 arg1Of recruitment,of
R491 T570 T577 arg1Of recruitment,to
R492 T573 T571 arg2Of protein,of
R493 T573 T572 arg1Of protein,HOIL-1L-interacting
R494 T573 T574 arg1Of protein,(
R495 T575 T574 arg2Of HOIP,(
R496 T576 T574 arg3Of ),(
R497 T580 T577 arg2Of domain,to
R498 T580 T578 arg1Of domain,the
R499 T580 T579 arg1Of domain,cytoplasmic
R500 T580 T581 arg1Of domain,of
R501 T582 T581 arg2Of CD40,of
R502 T584 T569 arg3Of suggesting,mediates
R503 T586 T587 arg1Of HOIP,has
R504 T587 T584 arg2Of has,suggesting
R505 T587 T585 arg1Of has,that
R506 T587 T590 arg1Of has,in
R507 T589 T587 arg2Of role,has
R508 T589 T588 arg1Of role,a
R509 T594 T590 arg2Of pathway,in
R510 T594 T591 arg1Of pathway,the
R511 T594 T592 arg1Of pathway,CD40
R512 T594 T593 arg1Of pathway,signaling
R513 T596 T595 arg1Of determine,To
R514 T598 T596 arg2Of role,determine
R515 T598 T597 arg1Of role,the
R516 T598 T599 arg1Of role,of
R517 T598 T601 arg1Of role,in
R518 T600 T599 arg2Of HOIP,of
R519 T603 T601 arg2Of signaling,in
R520 T603 T602 arg1Of signaling,CD40
R521 T605 T606 arg1Of we,used
R522 T606 T595 modOf used,To
R523 T606 T604 arg1Of used,","
R524 T606 T611 modOf used,to
R525 T609 T606 arg2Of gene,used
R526 T609 T607 arg1Of gene,somatic
R527 T609 T608 arg1Of gene,cell
R528 T610 T606 arg3Of targeting,used
R529 T612 T611 arg1Of generate,to
R530 T616 T612 arg2Of lines,generate
R531 T616 T613 arg1Of lines,mouse
R532 T616 T614 arg1Of lines,B
R533 T616 T615 arg1Of lines,cell
R534 T616 T617 arg1Of lines,deficient
R535 T617 T618 arg1Of deficient,in
R536 T619 T618 arg2Of HOIP,in
R537 T620 T621 arg1Of We,found
R538 T625 T623 arg1Of upregulation,the
R539 T625 T624 arg1Of upregulation,CD40-induced
R540 T625 T626 arg1Of upregulation,of
R541 T625 T628 arg1Of upregulation,and
R542 T627 T626 arg2Of CD80,of
R543 T628 T635 arg1Of and,were
R544 T628 T636 arg1Of and,defective
R545 T629 T628 arg2Of activation,and
R546 T629 T630 arg1Of activation,of
R547 T634 T630 arg2Of transcription,of
R548 T634 T631 arg1Of transcription,germline
R549 T634 T632 arg1Of transcription,immunoglobulin
R550 T634 T633 arg1Of transcription,epsilon
R551 T635 T621 arg2Of were,found
R552 T635 T622 arg1Of were,that
R553 T635 T637 arg1Of were,in
R554 T636 T635 arg2Of defective,were
R555 T639 T637 arg2Of cells,in
R556 T639 T638 arg1Of cells,HOIP-deficient
R557 T640 T642 arg1Of We,found
R558 T642 T641 arg1Of found,also
R559 T646 T644 arg1Of activation,the
R560 T646 T645 arg1Of activation,CD40-mediated
R561 T646 T647 arg1Of activation,of
R562 T646 T652 arg1Of activation,was
R563 T646 T653 arg1Of activation,impaired
R564 T648 T649 arg1Of NF-κB,and
R565 T650 T649 arg2Of c-Jun,and
R566 T651 T647 arg2Of kinase,of
R567 T651 T648 arg1Of kinase,NF-κB
R568 T651 T650 arg1Of kinase,c-Jun
R569 T652 T642 arg2Of was,found
R570 T652 T643 arg1Of was,that
R571 T653 T652 arg2Of impaired,was
R572 T654 T655 arg1Of Recruitment,of
R573 T654 T659 arg1Of Recruitment,to
R574 T654 T664 arg1Of Recruitment,was
R575 T654 T665 arg1Of Recruitment,undetectable
R576 T658 T655 arg2Of proteins,of
R577 T658 T656 arg1Of proteins,IκB
R578 T658 T657 arg1Of proteins,kinase
R579 T663 T659 arg2Of complex,to
R580 T663 T660 arg1Of complex,the
R581 T663 T661 arg1Of complex,CD40
R582 T663 T662 arg1Of complex,signaling
R583 T664 T666 arg1Of was,in
R584 T664 T669 arg1Of was,","
R585 T665 T664 arg2Of undetectable,was
R586 T668 T666 arg2Of cells,in
R587 T668 T667 arg1Of cells,HOIP-deficient
R588 T671 T664 arg3Of explaining,was
R589 T671 T670 arg1Of explaining,potentially
R590 T676 T674 arg2Of activation,in
R591 T676 T675 arg1Of activation,NF-κB
R592 T677 T678 arg1Of Restoration,of
R593 T677 T681 arg1Of Restoration,reversed
R594 T680 T678 arg2Of expression,of
R595 T680 T679 arg1Of expression,HOIP
R596 T683 T681 arg2Of defects,reversed
R597 T683 T682 arg1Of defects,the
R598 T683 T684 arg1Of defects,in
R599 T686 T687 arg1Of activation,and
R600 T687 T684 arg2Of and,in
R601 T687 T685 arg1Of and,cellular
R602 T688 T687 arg2Of signaling,and
R603 T690 T689 arg1Of results,These
R604 T690 T691 arg1Of results,reveal
R605 T691 T693 arg1Of reveal,as
R606 T692 T691 arg2Of HOIP,reveal
R607 T696 T693 arg2Of component,as
R608 T696 T694 arg1Of component,a
R609 T696 T695 arg1Of component,key
R610 T696 T697 arg1Of component,of
R611 T701 T697 arg2Of pathway,of
R612 T701 T698 arg1Of pathway,the
R613 T701 T699 arg1Of pathway,CD40
R614 T701 T700 arg1Of pathway,signaling
R699 T673 T671 arg2Of defect,explaining
R700 T673 T672 arg1Of defect,the
R701 T673 T674 arg1Of defect,in

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T146 0-4 NNP denotes CD40
T147 5-7 VBZ denotes is
T148 8-9 DT denotes a
T149 10-14 NN denotes cell
T150 15-22 NN denotes surface
T151 23-31 NN denotes receptor
T152 32-41 JJ denotes important
T153 42-44 IN denotes in
T154 45-48 DT denotes the
T155 49-59 NN denotes activation
T156 60-62 IN denotes of
T157 63-81 JJ denotes antigen-presenting
T158 82-87 NNS denotes cells
T159 88-94 IN denotes during
T160 95-101 JJ denotes immune
T161 102-111 NNS denotes responses
T162 111-112 . denotes .
T163 113-115 IN denotes In
T164 116-127 NNS denotes macrophages
T165 128-131 CC denotes and
T166 132-141 JJ denotes dendritic
T167 142-147 NNS denotes cells
T168 147-148 , denotes ,
T169 149-159 NN denotes engagement
T170 160-162 IN denotes of
T171 163-167 CD denotes CD40
T172 168-170 IN denotes by
T173 171-174 PRP$ denotes its
T174 175-181 NN denotes ligand
T175 182-187 NNP denotes CD154
T176 188-196 VBZ denotes provides
T177 197-204 NNS denotes signals
T178 205-213 JJ denotes critical
T179 214-217 IN denotes for
T180 218-232 JJ denotes anti-microbial
T181 233-236 CC denotes and
T182 237-238 NNP denotes T
T183 239-252 JJ denotes cell-mediated
T184 253-259 JJ denotes immune
T185 260-269 NNS denotes responses
T186 269-270 , denotes ,
T187 271-283 RB denotes respectively
T188 283-284 . denotes .
T189 285-287 IN denotes In
T190 288-289 NNP denotes B
T191 290-295 NNS denotes cells
T192 295-296 , denotes ,
T193 297-301 NNP denotes CD40
T194 302-311 VBG denotes signaling
T195 312-315 VBZ denotes has
T196 316-317 DT denotes a
T197 318-323 JJ denotes major
T198 324-328 NN denotes role
T199 329-331 IN denotes in
T200 332-342 VBG denotes regulating
T201 343-347 NN denotes cell
T202 348-361 NN denotes proliferation
T203 361-362 , denotes ,
T204 363-371 NN denotes antibody
T205 372-382 NN denotes production
T206 382-383 , denotes ,
T207 384-387 CC denotes and
T208 388-394 NN denotes memory
T209 395-396 NNP denotes B
T210 397-401 NN denotes cell
T211 402-413 NN denotes development
T212 413-414 . denotes .
T213 415-419 CD denotes CD40
T214 420-430 NN denotes engagement
T215 431-438 NNS denotes results
T216 439-441 IN denotes in
T217 442-445 DT denotes the
T218 446-455 NN denotes formation
T219 456-458 IN denotes of
T220 459-460 DT denotes a
T221 461-480 JJ denotes receptor-associated
T222 481-488 NN denotes complex
T223 489-493 WDT denotes that
T224 494-502 VBZ denotes mediates
T225 503-513 NN denotes activation
T226 514-516 IN denotes of
T227 517-522 NNP denotes NF-κB
T228 522-523 , denotes ,
T229 524-540 JJ denotes stress-activated
T230 541-548 NN denotes protein
T231 549-556 NNS denotes kinases
T232 556-557 , denotes ,
T233 558-561 CC denotes and
T234 562-567 JJ denotes other
T235 568-577 VBG denotes signaling
T236 578-587 NNS denotes molecules
T237 587-588 . denotes .
T238 589-596 RB denotes However
T239 596-597 , denotes ,
T240 598-601 DT denotes the
T241 602-612 NNS denotes mechanisms
T242 613-617 WDT denotes that
T243 618-622 VBP denotes link
T244 623-627 CD denotes CD40
T245 628-630 TO denotes to
T246 631-636 DT denotes these
T247 637-646 VBG denotes signaling
T248 647-653 NNS denotes events
T249 654-658 VBP denotes have
T250 659-663 VBN denotes been
T251 664-668 RB denotes only
T252 669-678 RB denotes partially
T253 679-692 VBN denotes characterized
T254 692-693 . denotes .
T255 694-699 VBN denotes Known
T256 700-710 NNS denotes components
T257 711-713 IN denotes of
T258 714-717 DT denotes the
T259 718-722 NNP denotes CD40
T260 723-732 VBG denotes signaling
T261 733-740 JJ denotes complex
T262 741-748 VBP denotes include
T263 749-756 NNS denotes members
T264 757-759 IN denotes of
T265 760-763 DT denotes the
T266 764-767 NNP denotes TNF
T267 768-787 JJ denotes receptor-associated
T268 788-794 NN denotes factor
T269 795-796 -LRB- denotes (
T270 796-800 NNP denotes TRAF
T271 800-801 -RRB- denotes )
T272 802-808 NN denotes family
T273 809-811 IN denotes of
T274 812-820 NNS denotes proteins
T275 820-821 . denotes .
T276 822-824 PRP denotes We
T277 825-835 RB denotes previously
T278 836-842 VBD denotes showed
T279 843-847 IN denotes that
T280 848-851 DT denotes the
T281 852-856 NNP denotes TRAF
T282 857-863 NN denotes family
T283 864-870 NN denotes member
T284 871-876 CD denotes TRAF2
T285 877-885 VBZ denotes mediates
T286 886-897 NN denotes recruitment
T287 898-900 IN denotes of
T288 901-920 JJ denotes HOIL-1L-interacting
T289 921-928 NN denotes protein
T290 929-930 -LRB- denotes (
T291 930-934 NNP denotes HOIP
T292 934-935 -RRB- denotes )
T293 936-938 TO denotes to
T294 939-942 DT denotes the
T295 943-954 JJ denotes cytoplasmic
T296 955-961 NN denotes domain
T297 962-964 IN denotes of
T298 965-969 NNP denotes CD40
T299 969-970 , denotes ,
T300 971-981 VBG denotes suggesting
T301 982-986 IN denotes that
T302 987-991 NNP denotes HOIP
T303 992-995 VBZ denotes has
T304 996-997 DT denotes a
T305 998-1002 NN denotes role
T306 1003-1005 IN denotes in
T307 1006-1009 DT denotes the
T308 1010-1014 NNP denotes CD40
T309 1015-1024 VBG denotes signaling
T310 1025-1032 NN denotes pathway
T311 1032-1033 . denotes .
T312 1034-1036 TO denotes To
T313 1037-1046 VB denotes determine
T314 1047-1050 DT denotes the
T315 1051-1055 NN denotes role
T316 1056-1058 IN denotes of
T317 1059-1063 NNP denotes HOIP
T318 1064-1066 IN denotes in
T319 1067-1071 NNP denotes CD40
T320 1072-1081 VBG denotes signaling
T321 1081-1082 , denotes ,
T322 1083-1085 PRP denotes we
T323 1086-1090 VBD denotes used
T324 1091-1098 JJ denotes somatic
T325 1099-1103 NN denotes cell
T326 1104-1108 NN denotes gene
T327 1109-1118 VBG denotes targeting
T328 1119-1121 TO denotes to
T329 1122-1130 VB denotes generate
T330 1131-1136 NN denotes mouse
T331 1137-1138 NNP denotes B
T332 1139-1143 NN denotes cell
T333 1144-1149 NNS denotes lines
T334 1150-1159 VBP denotes deficient
T335 1160-1162 IN denotes in
T336 1163-1167 NNP denotes HOIP
T337 1167-1168 . denotes .
T338 1169-1171 PRP denotes We
T339 1172-1177 VBD denotes found
T340 1178-1182 IN denotes that
T341 1183-1186 DT denotes the
T342 1187-1199 JJ denotes CD40-induced
T343 1200-1212 NN denotes upregulation
T344 1213-1215 IN denotes of
T345 1216-1220 NNP denotes CD80
T346 1221-1224 CC denotes and
T347 1225-1235 NN denotes activation
T348 1236-1238 IN denotes of
T349 1239-1247 NN denotes germline
T350 1248-1262 NN denotes immunoglobulin
T351 1263-1270 NN denotes epsilon
T352 1271-1284 NN denotes transcription
T353 1285-1289 VBD denotes were
T354 1290-1299 JJ denotes defective
T355 1300-1302 IN denotes in
T356 1303-1317 JJ denotes HOIP-deficient
T357 1318-1323 NNS denotes cells
T358 1323-1324 . denotes .
T359 1325-1327 PRP denotes We
T360 1328-1332 RB denotes also
T361 1333-1338 VBD denotes found
T362 1339-1343 IN denotes that
T363 1344-1347 DT denotes the
T364 1348-1361 JJ denotes CD40-mediated
T365 1362-1372 NN denotes activation
T366 1373-1375 IN denotes of
T367 1376-1381 NN denotes NF-κB
T368 1382-1385 CC denotes and
T369 1386-1391 JJ denotes c-Jun
T370 1392-1398 NN denotes kinase
T371 1399-1402 VBD denotes was
T372 1403-1411 VBN denotes impaired
T373 1411-1412 . denotes .
T374 1413-1424 NN denotes Recruitment
T375 1425-1427 IN denotes of
T376 1428-1431 NNP denotes IκB
T377 1432-1438 NN denotes kinase
T378 1439-1447 NNS denotes proteins
T379 1448-1450 TO denotes to
T380 1451-1454 DT denotes the
T381 1455-1459 NNP denotes CD40
T382 1460-1469 VBG denotes signaling
T383 1470-1477 NN denotes complex
T384 1478-1481 VBD denotes was
T385 1482-1494 JJ denotes undetectable
T386 1495-1497 IN denotes in
T387 1498-1512 JJ denotes HOIP-deficient
T388 1513-1518 NNS denotes cells
T389 1518-1519 , denotes ,
T390 1520-1531 RB denotes potentially
T391 1532-1542 VBG denotes explaining
T392 1543-1546 DT denotes the
T393 1547-1553 NN denotes defect
T394 1554-1556 IN denotes in
T395 1557-1562 JJ denotes NF-κB
T396 1563-1573 NN denotes activation
T397 1573-1574 . denotes .
T398 1575-1586 NNP denotes Restoration
T399 1587-1589 IN denotes of
T400 1590-1594 NNP denotes HOIP
T401 1595-1605 NN denotes expression
T402 1606-1614 VBD denotes reversed
T403 1615-1618 DT denotes the
T404 1619-1626 NNS denotes defects
T405 1627-1629 IN denotes in
T406 1630-1638 JJ denotes cellular
T407 1639-1649 NN denotes activation
T408 1650-1653 CC denotes and
T409 1654-1663 VBG denotes signaling
T410 1663-1664 . denotes .
T411 1665-1670 DT denotes These
T412 1671-1678 NNS denotes results
T413 1679-1685 VBP denotes reveal
T414 1686-1690 NNP denotes HOIP
T415 1691-1693 IN denotes as
T416 1694-1695 DT denotes a
T417 1696-1699 JJ denotes key
T418 1700-1709 NN denotes component
T419 1710-1712 IN denotes of
T420 1713-1716 DT denotes the
T421 1717-1721 NNP denotes CD40
T422 1722-1731 VBG denotes signaling
T423 1732-1739 NN denotes pathway
T424 1739-1740 . denotes .
R94 T172 T169 prep by,engagement
R95 T173 T175 poss its,CD154
R70 T148 T151 det a,receptor
R71 T149 T150 compound cell,surface
R72 T150 T151 compound surface,receptor
R73 T151 T147 attr receptor,is
R74 T152 T151 amod important,receptor
R75 T153 T152 prep in,important
R76 T154 T155 det the,activation
R77 T155 T153 pobj activation,in
R78 T156 T155 prep of,activation
R79 T157 T158 amod antigen-presenting,cells
R80 T158 T156 pobj cells,of
R81 T159 T152 prep during,important
R82 T160 T161 amod immune,responses
R83 T161 T159 pobj responses,during
R85 T163 T176 prep In,provides
R86 T164 T163 pobj macrophages,In
R87 T165 T164 cc and,macrophages
R88 T166 T167 amod dendritic,cells
R89 T167 T164 conj cells,macrophages
R90 T168 T167 punct ",",cells
R91 T169 T176 nsubj engagement,provides
R92 T170 T169 prep of,engagement
R93 T171 T170 pobj CD40,of
R96 T174 T175 compound ligand,CD154
R97 T175 T172 pobj CD154,by
R98 T176 T176 ROOT provides,provides
R99 T177 T176 dobj signals,provides
R100 T178 T177 amod critical,signals
R101 T179 T178 prep for,critical
R102 T180 T179 pobj anti-microbial,for
R103 T181 T180 cc and,anti-microbial
R104 T182 T185 nmod T,responses
R105 T183 T185 amod cell-mediated,responses
R106 T184 T185 amod immune,responses
R107 T185 T180 conj responses,anti-microbial
R108 T186 T185 punct ",",responses
R109 T187 T185 advmod respectively,responses
R110 T188 T176 punct .,provides
R111 T189 T195 prep In,has
R112 T190 T191 compound B,cells
R113 T191 T189 pobj cells,In
R114 T192 T195 punct ",",has
R115 T193 T194 nsubj CD40,signaling
R116 T194 T195 nsubj signaling,has
R117 T195 T195 ROOT has,has
R118 T196 T198 det a,role
R119 T197 T198 amod major,role
R120 T198 T195 dobj role,has
R121 T199 T198 prep in,role
R122 T200 T199 pcomp regulating,in
R123 T201 T202 compound cell,proliferation
R124 T202 T200 dobj proliferation,regulating
R125 T203 T205 punct ",",production
R126 T204 T205 compound antibody,production
R127 T205 T198 conj production,role
R128 T206 T205 punct ",",production
R129 T207 T205 cc and,production
R130 T208 T209 compound memory,B
R131 T209 T211 compound B,development
R132 T210 T211 compound cell,development
R133 T211 T205 conj development,production
R134 T212 T195 punct .,has
R135 T213 T215 nummod CD40,results
R136 T214 T215 compound engagement,results
R137 T215 T215 ROOT results,results
R138 T216 T215 prep in,results
R139 T217 T218 det the,formation
R140 T218 T216 pobj formation,in
R141 T219 T218 prep of,formation
R142 T220 T222 det a,complex
R143 T221 T222 amod receptor-associated,complex
R144 T222 T219 pobj complex,of
R145 T223 T224 nsubj that,mediates
R146 T224 T222 relcl mediates,complex
R147 T225 T224 dobj activation,mediates
R148 T226 T225 prep of,activation
R149 T227 T226 pobj NF-κB,of
R150 T228 T227 punct ",",NF-κB
R151 T229 T231 amod stress-activated,kinases
R152 T230 T231 compound protein,kinases
R153 T231 T225 conj kinases,activation
R154 T232 T231 punct ",",kinases
R155 T233 T231 cc and,kinases
R156 T234 T236 amod other,molecules
R157 T235 T236 amod signaling,molecules
R158 T236 T231 conj molecules,kinases
R159 T237 T215 punct .,results
R160 T238 T250 advmod However,been
R161 T239 T250 punct ",",been
R162 T240 T241 det the,mechanisms
R163 T241 T250 nsubj mechanisms,been
R164 T242 T243 nsubj that,link
R165 T243 T241 relcl link,mechanisms
R166 T244 T243 dobj CD40,link
R167 T245 T243 prep to,link
R168 T246 T248 det these,events
R169 T247 T248 amod signaling,events
R170 T248 T245 pobj events,to
R171 T249 T250 aux have,been
R172 T250 T250 ROOT been,been
R173 T251 T253 advmod only,characterized
R174 T252 T253 advmod partially,characterized
R175 T253 T250 acomp characterized,been
R176 T254 T253 punct .,characterized
R177 T255 T256 amod Known,components
R178 T256 T262 nsubj components,include
R179 T257 T256 prep of,components
R180 T258 T259 det the,CD40
R181 T259 T257 pobj CD40,of
R182 T260 T256 acl signaling,components
R183 T261 T260 pcomp complex,signaling
R184 T262 T262 ROOT include,include
R185 T263 T262 dobj members,include
R186 T264 T263 prep of,members
R187 T265 T268 det the,factor
R188 T266 T268 nmod TNF,factor
R189 T267 T268 amod receptor-associated,factor
R190 T268 T264 pobj factor,of
R191 T269 T270 punct (,TRAF
R192 T270 T268 appos TRAF,factor
R193 T271 T270 punct ),TRAF
R194 T272 T263 conj family,members
R195 T273 T272 prep of,family
R196 T274 T273 pobj proteins,of
R197 T275 T262 punct .,include
R198 T276 T278 nsubj We,showed
R199 T277 T278 advmod previously,showed
R200 T278 T278 ROOT showed,showed
R201 T279 T285 mark that,mediates
R202 T280 T283 det the,member
R203 T281 T283 compound TRAF,member
R204 T282 T283 compound family,member
R205 T283 T285 nsubj member,mediates
R206 T284 T285 nummod TRAF2,mediates
R207 T285 T278 ccomp mediates,showed
R208 T286 T285 dobj recruitment,mediates
R209 T287 T286 prep of,recruitment
R210 T288 T289 amod HOIL-1L-interacting,protein
R211 T289 T287 pobj protein,of
R212 T290 T291 punct (,HOIP
R213 T291 T289 appos HOIP,protein
R214 T292 T285 punct ),mediates
R215 T293 T285 prep to,mediates
R216 T294 T296 det the,domain
R217 T295 T296 amod cytoplasmic,domain
R218 T296 T293 pobj domain,to
R219 T297 T296 prep of,domain
R220 T298 T297 pobj CD40,of
R221 T299 T285 punct ",",mediates
R222 T300 T285 acl suggesting,mediates
R223 T301 T303 mark that,has
R224 T302 T303 nsubj HOIP,has
R225 T303 T300 ccomp has,suggesting
R226 T304 T305 det a,role
R227 T305 T303 dobj role,has
R228 T306 T305 prep in,role
R229 T307 T310 det the,pathway
R230 T308 T310 nmod CD40,pathway
R231 T309 T310 amod signaling,pathway
R232 T310 T306 pobj pathway,in
R233 T311 T278 punct .,showed
R234 T312 T313 aux To,determine
R235 T313 T323 advcl determine,used
R236 T314 T315 det the,role
R237 T315 T313 dobj role,determine
R238 T316 T315 prep of,role
R239 T317 T316 pobj HOIP,of
R240 T318 T315 prep in,role
R241 T319 T318 pobj CD40,in
R242 T320 T315 acl signaling,role
R243 T321 T323 punct ",",used
R244 T322 T323 nsubj we,used
R245 T323 T323 ROOT used,used
R246 T324 T326 compound somatic,gene
R247 T325 T326 compound cell,gene
R248 T326 T323 dobj gene,used
R249 T327 T326 acl targeting,gene
R250 T328 T329 aux to,generate
R251 T329 T327 xcomp generate,targeting
R252 T330 T333 compound mouse,lines
R253 T331 T332 compound B,cell
R254 T332 T333 compound cell,lines
R255 T333 T329 dobj lines,generate
R256 T334 T323 oprd deficient,used
R257 T335 T334 prep in,deficient
R258 T336 T335 pobj HOIP,in
R259 T337 T323 punct .,used
R260 T338 T339 nsubj We,found
R261 T339 T339 ROOT found,found
R262 T340 T353 mark that,were
R263 T341 T343 det the,upregulation
R264 T342 T343 amod CD40-induced,upregulation
R265 T343 T353 nsubj upregulation,were
R266 T344 T343 prep of,upregulation
R267 T345 T344 pobj CD80,of
R268 T346 T345 cc and,CD80
R269 T347 T343 conj activation,upregulation
R270 T348 T347 prep of,activation
R271 T349 T352 nmod germline,transcription
R272 T350 T352 compound immunoglobulin,transcription
R273 T351 T352 compound epsilon,transcription
R274 T352 T348 pobj transcription,of
R275 T353 T339 ccomp were,found
R276 T354 T353 acomp defective,were
R277 T355 T354 prep in,defective
R278 T356 T357 amod HOIP-deficient,cells
R279 T357 T355 pobj cells,in
R280 T358 T339 punct .,found
R281 T359 T361 nsubj We,found
R282 T360 T361 advmod also,found
R283 T361 T361 ROOT found,found
R284 T362 T372 mark that,impaired
R285 T363 T365 det the,activation
R286 T364 T365 amod CD40-mediated,activation
R287 T365 T372 nsubjpass activation,impaired
R288 T366 T365 prep of,activation
R289 T367 T366 pobj NF-κB,of
R290 T368 T367 cc and,NF-κB
R291 T369 T370 amod c-Jun,kinase
R292 T370 T367 conj kinase,NF-κB
R293 T371 T372 auxpass was,impaired
R294 T372 T361 ccomp impaired,found
R295 T373 T361 punct .,found
R296 T374 T384 nsubj Recruitment,was
R297 T375 T374 prep of,Recruitment
R298 T376 T378 compound IκB,proteins
R299 T377 T378 compound kinase,proteins
R300 T378 T375 pobj proteins,of
R301 T379 T374 prep to,Recruitment
R302 T380 T381 det the,CD40
R303 T381 T379 pobj CD40,to
R304 T382 T383 compound signaling,complex
R305 T383 T384 nsubj complex,was
R306 T384 T384 ROOT was,was
R307 T385 T384 acomp undetectable,was
R308 T386 T385 prep in,undetectable
R309 T387 T388 amod HOIP-deficient,cells
R310 T388 T386 pobj cells,in
R311 T389 T384 punct ",",was
R312 T390 T391 advmod potentially,explaining
R313 T391 T384 advcl explaining,was
R314 T392 T393 det the,defect
R315 T393 T391 dobj defect,explaining
R316 T394 T393 prep in,defect
R317 T395 T396 amod NF-κB,activation
R318 T396 T394 pobj activation,in
R319 T397 T384 punct .,was
R320 T398 T402 nsubj Restoration,reversed
R321 T399 T398 prep of,Restoration
R322 T400 T401 compound HOIP,expression
R323 T401 T399 pobj expression,of
R324 T402 T402 ROOT reversed,reversed
R325 T403 T404 det the,defects
R326 T404 T402 dobj defects,reversed
R327 T405 T404 prep in,defects
R328 T406 T407 amod cellular,activation
R329 T407 T405 pobj activation,in
R330 T408 T407 cc and,activation
R331 T409 T407 conj signaling,activation
R332 T410 T402 punct .,reversed
R333 T411 T412 det These,results
R334 T412 T413 nsubj results,reveal
R335 T413 T413 ROOT reveal,reveal
R336 T414 T413 dobj HOIP,reveal
R337 T415 T413 prep as,reveal
R338 T416 T418 det a,component
R339 T417 T418 amod key,component
R340 T418 T415 pobj component,as
R341 T419 T418 prep of,component
R342 T420 T421 det the,CD40
R343 T421 T419 pobj CD40,of
R344 T422 T413 advcl signaling,reveal
R345 T423 T422 dobj pathway,signaling
R346 T424 T413 punct .,reveal

GO-BP

Id Subject Object Predicate Lexical cue
T754 95-111 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T755 253-269 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T756 197-204 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T757 302-311 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T758 568-577 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T759 637-646 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T760 723-732 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T761 1015-1024 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T762 1072-1081 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T763 1460-1469 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T764 1654-1663 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T765 1722-1731 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T766 239-259 http://purl.obolibrary.org/obo/GO_0002449 denotes cell-mediated immune
T767 239-259 http://purl.obolibrary.org/obo/GO_0002456 denotes cell-mediated immune
T768 239-259 http://purl.obolibrary.org/obo/GO_0019724 denotes cell-mediated immune
T769 239-259 http://purl.obolibrary.org/obo/GO_0002228 denotes cell-mediated immune
T770 239-269 http://purl.obolibrary.org/obo/GO_0002443 denotes cell-mediated immune responses
T771 239-259 http://purl.obolibrary.org/obo/GO_0001909 denotes cell-mediated immune
T772 343-361 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation
T773 363-382 http://purl.obolibrary.org/obo/GO_0002377 denotes antibody production
T774 388-394 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T775 397-413 http://purl.obolibrary.org/obo/GO_0048468 denotes cell development
T776 402-413 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T777 446-455 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T778 446-469 http://purl.obolibrary.org/obo/GO_0032800 denotes formation of a receptor
T779 503-522 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T780 1362-1381 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T781 1557-1573 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T782 531-556 http://purl.obolibrary.org/obo/GO_0034199 denotes activated protein kinases
T783 531-556 http://purl.obolibrary.org/obo/GO_0032147 denotes activated protein kinases
T784 531-556 http://purl.obolibrary.org/obo/GO_0030295 denotes activated protein kinases
T785 531-556 http://purl.obolibrary.org/obo/GO_0032111 denotes activated protein kinases
T786 1010-1032 http://purl.obolibrary.org/obo/GO_0023035 denotes CD40 signaling pathway
T787 1717-1739 http://purl.obolibrary.org/obo/GO_0023035 denotes CD40 signaling pathway
T788 1010-1032 http://purl.obolibrary.org/obo/GO_2000348 denotes CD40 signaling pathway
T789 1717-1739 http://purl.obolibrary.org/obo/GO_2000348 denotes CD40 signaling pathway
T790 1015-1032 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T791 1722-1739 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T792 1271-1284 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T793 1630-1638 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular

GO-MF

Id Subject Object Predicate Lexical cue
T794 175-181 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T795 363-371 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T796 1248-1262 http://purl.obolibrary.org/obo/GO_0003823 denotes immunoglobulin
T797 531-556 http://purl.obolibrary.org/obo/GO_0030295 denotes activated protein kinases

GO-CC

Id Subject Object Predicate Lexical cue
T798 10-14 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T799 239-243 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T800 343-347 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T801 397-401 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T802 1099-1103 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T803 1139-1143 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T804 1318-1323 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T805 1513-1518 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T806 10-22 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface
T807 363-371 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T808 363-371 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T809 481-502 http://purl.obolibrary.org/obo/GO_0016592 denotes complex that mediates

sentences

Id Subject Object Predicate Lexical cue
T122 0-112 Sentence denotes CD40 is a cell surface receptor important in the activation of antigen-presenting cells during immune responses.
T123 113-284 Sentence denotes In macrophages and dendritic cells, engagement of CD40 by its ligand CD154 provides signals critical for anti-microbial and T cell-mediated immune responses, respectively.
T124 285-414 Sentence denotes In B cells, CD40 signaling has a major role in regulating cell proliferation, antibody production, and memory B cell development.
T125 415-588 Sentence denotes CD40 engagement results in the formation of a receptor-associated complex that mediates activation of NF-κB, stress-activated protein kinases, and other signaling molecules.
T126 589-693 Sentence denotes However, the mechanisms that link CD40 to these signaling events have been only partially characterized.
T127 694-821 Sentence denotes Known components of the CD40 signaling complex include members of the TNF receptor-associated factor (TRAF) family of proteins.
T128 822-1033 Sentence denotes We previously showed that the TRAF family member TRAF2 mediates recruitment of HOIL-1L-interacting protein (HOIP) to the cytoplasmic domain of CD40, suggesting that HOIP has a role in the CD40 signaling pathway.
T129 1034-1168 Sentence denotes To determine the role of HOIP in CD40 signaling, we used somatic cell gene targeting to generate mouse B cell lines deficient in HOIP.
T130 1169-1324 Sentence denotes We found that the CD40-induced upregulation of CD80 and activation of germline immunoglobulin epsilon transcription were defective in HOIP-deficient cells.
T131 1325-1412 Sentence denotes We also found that the CD40-mediated activation of NF-κB and c-Jun kinase was impaired.
T132 1413-1574 Sentence denotes Recruitment of IκB kinase proteins to the CD40 signaling complex was undetectable in HOIP-deficient cells, potentially explaining the defect in NF-κB activation.
T133 1575-1664 Sentence denotes Restoration of HOIP expression reversed the defects in cellular activation and signaling.
T134 1665-1740 Sentence denotes These results reveal HOIP as a key component of the CD40 signaling pathway.
T3 0-112 Sentence denotes CD40 is a cell surface receptor important in the activation of antigen-presenting cells during immune responses.
T4 113-284 Sentence denotes In macrophages and dendritic cells, engagement of CD40 by its ligand CD154 provides signals critical for anti-microbial and T cell-mediated immune responses, respectively.
T5 285-414 Sentence denotes In B cells, CD40 signaling has a major role in regulating cell proliferation, antibody production, and memory B cell development.
T6 415-588 Sentence denotes CD40 engagement results in the formation of a receptor-associated complex that mediates activation of NF-κB, stress-activated protein kinases, and other signaling molecules.
T7 589-693 Sentence denotes However, the mechanisms that link CD40 to these signaling events have been only partially characterized.
T8 694-821 Sentence denotes Known components of the CD40 signaling complex include members of the TNF receptor-associated factor (TRAF) family of proteins.
T9 822-1033 Sentence denotes We previously showed that the TRAF family member TRAF2 mediates recruitment of HOIL-1L-interacting protein (HOIP) to the cytoplasmic domain of CD40, suggesting that HOIP has a role in the CD40 signaling pathway.
T10 1034-1168 Sentence denotes To determine the role of HOIP in CD40 signaling, we used somatic cell gene targeting to generate mouse B cell lines deficient in HOIP.
T11 1169-1324 Sentence denotes We found that the CD40-induced upregulation of CD80 and activation of germline immunoglobulin epsilon transcription were defective in HOIP-deficient cells.
T12 1325-1412 Sentence denotes We also found that the CD40-mediated activation of NF-κB and c-Jun kinase was impaired.
T13 1413-1574 Sentence denotes Recruitment of IκB kinase proteins to the CD40 signaling complex was undetectable in HOIP-deficient cells, potentially explaining the defect in NF-κB activation.
T14 1575-1664 Sentence denotes Restoration of HOIP expression reversed the defects in cellular activation and signaling.
T15 1665-1740 Sentence denotes These results reveal HOIP as a key component of the CD40 signaling pathway.

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T705 0-4 P25942 denotes CD40
T706 163-167 P25942 denotes CD40
T707 182-187 P29965 denotes CD154
T708 297-301 P25942 denotes CD40
T709 415-419 P25942 denotes CD40
T710 524-556 P53778 denotes stress-activated protein kinases
T711 524-556 O15264 denotes stress-activated protein kinases
T712 623-627 P25942 denotes CD40
T713 718-722 P25942 denotes CD40
T714 764-767 P01375 denotes TNF
T715 764-794 Q13114 denotes TNF receptor-associated factor
T716 764-794 Q12933 denotes TNF receptor-associated factor
T717 764-794 Q9Y4K3 denotes TNF receptor-associated factor
T718 871-876 Q12933 denotes TRAF2
T719 901-928 Q96EP0 denotes HOIL-1L-interacting protein
T720 930-934 Q96EP0 denotes HOIP
T721 965-969 P25942 denotes CD40
T722 987-991 Q96EP0 denotes HOIP
T723 1010-1014 P25942 denotes CD40
T724 1059-1063 Q96EP0 denotes HOIP
T725 1067-1071 P25942 denotes CD40
T726 1163-1167 Q96EP0 denotes HOIP
T727 1187-1191 P25942 denotes CD40
T728 1216-1220 P33681 denotes CD80
T729 1303-1307 Q96EP0 denotes HOIP
T730 1348-1352 P25942 denotes CD40
T731 1386-1391 P05412 denotes c-Jun
T732 1388-1391 P05412 denotes Jun
T733 1428-1438 Q60680-2 denotes IκB kinase
T734 1428-1438 O15111 denotes IκB kinase
T735 1455-1459 P25942 denotes CD40
T736 1498-1502 Q96EP0 denotes HOIP
T737 1590-1594 Q96EP0 denotes HOIP
T738 1686-1690 Q96EP0 denotes HOIP
T739 1717-1721 P25942 denotes CD40

test2

Id Subject Object Predicate Lexical cue
T44 0-4 Protein denotes CD40
T45 149-159 Binding denotes engagement
T46 163-167 Protein denotes CD40
T47 175-181 Protein denotes ligand
T48 182-187 Protein denotes CD154
T49 297-301 Protein denotes CD40
T50 415-419 Protein denotes CD40
T51 420-430 Binding denotes engagement
T52 623-627 Protein denotes CD40
T53 871-876 Protein denotes TRAF2
T54 877-885 Positive_regulation denotes mediates
T55 886-897 Binding denotes recruitment
T56 901-928 Protein denotes HOIL-1L-interacting protein
T57 930-934 Protein denotes HOIP
T58 943-961 Entity denotes cytoplasmic domain
T59 965-969 Protein denotes CD40
T60 987-991 Protein denotes HOIP
T61 1010-1014 Protein denotes CD40
T62 1059-1063 Protein denotes HOIP
T63 1067-1071 Protein denotes CD40
T64 1150-1159 Negative_regulation denotes deficient
T65 1163-1167 Protein denotes HOIP
T66 1187-1191 Protein denotes CD40
T67 1192-1199 Positive_regulation denotes induced
T68 1200-1212 Positive_regulation denotes upregulation
T69 1216-1220 Protein denotes CD80
T70 1225-1235 Positive_regulation denotes activation
T71 1271-1284 Transcription denotes transcription
T72 1303-1307 Protein denotes HOIP
T73 1308-1317 Negative_regulation denotes deficient
T74 1348-1352 Protein denotes CD40
T75 1498-1502 Protein denotes HOIP
T76 1503-1512 Negative_regulation denotes deficient
T77 1590-1594 Protein denotes HOIP
T78 1595-1605 Gene_expression denotes expression
T79 1686-1690 Protein denotes HOIP
T80 1717-1721 Protein denotes CD40
R21 T46 T45 themeOf CD40,engagement
R22 T48 T45 themeOf CD154,engagement
R23 T50 T51 themeOf CD40,engagement
R24 T53 T54 causeOf TRAF2,mediates
R25 T55 T54 themeOf recruitment,mediates
R26 T56 T55 themeOf HOIL-1L-interacting protein,recruitment
R27 T57 T56 equivalentTo HOIP,HOIL-1L-interacting protein
R28 T58 T55 themeOf cytoplasmic domain,recruitment
R29 T58 T59 partOf cytoplasmic domain,CD40
R30 T65 T64 themeOf HOIP,deficient
R31 T66 T67 causeOf CD40,induced
R32 T68 T67 themeOf upregulation,induced
R33 T69 T68 themeOf CD80,upregulation
R34 T71 T70 themeOf transcription,activation
R35 T72 T73 themeOf HOIP,deficient
R36 T75 T76 themeOf HOIP,deficient
R37 T77 T78 themeOf HOIP,expression