PMC:314463 / 9386-36753 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T2547	9-22	JJ	denotes	Morphological
T2548	23-33	NNS	denotes	Components
T2549	34-36	IN	denotes	of
T2550	37-49	JJ	denotes	Dorsoventral
T2551	55-66	NNS	denotes	Differences
T2552	50-54	NN	denotes	Skin
T2553	66-287	sentence	denotes	Besides the obvious change in hair color that frequently distinguishes dorsal from ventral skin, casual observation suggests there are additional differences in hair length, distribution of hair type, and skin thickness.
T2554	67-74	IN	denotes	Besides
T2555	183-191	VBZ	denotes	suggests
T2556	75-78	DT	denotes	the
T2557	87-93	NN	denotes	change
T2558	79-86	JJ	denotes	obvious
T2559	94-96	IN	denotes	in
T2560	97-101	NN	denotes	hair
T2561	102-107	NN	denotes	color
T2562	108-112	WDT	denotes	that
T2563	124-137	VBZ	denotes	distinguishes
T2564	113-123	RB	denotes	frequently
T2565	138-144	JJ	denotes	dorsal
T2566	145-149	IN	denotes	from
T2567	150-157	JJ	denotes	ventral
T2568	158-162	NN	denotes	skin
T2569	162-164	,	denotes	,
T2570	164-170	JJ	denotes	casual
T2571	171-182	NN	denotes	observation
T2572	192-197	EX	denotes	there
T2573	198-201	VBP	denotes	are
T2574	202-212	JJ	denotes	additional
T2575	213-224	NNS	denotes	differences
T2576	225-227	IN	denotes	in
T2577	228-232	NN	denotes	hair
T2578	233-239	NN	denotes	length
T2579	239-241	,	denotes	,
T2580	241-253	NN	denotes	distribution
T2581	254-256	IN	denotes	of
T2582	257-261	NN	denotes	hair
T2583	262-266	NN	denotes	type
T2584	266-268	,	denotes	,
T2585	268-271	CC	denotes	and
T2586	272-276	NN	denotes	skin
T2587	277-286	NN	denotes	thickness
T2588	286-287	.	denotes	.
T2589	287-507	sentence	denotes	Furthermore, dorsoventral differences in pigmentation can represent differences in the number and/or differentiated state of pigment cells, as well as the type of pigment synthesized in response to expression of Agouti.
T2590	288-299	RB	denotes	Furthermore
T2591	346-355	VB	denotes	represent
T2592	299-301	,	denotes	,
T2593	301-313	JJ	denotes	dorsoventral
T2594	314-325	NNS	denotes	differences
T2595	326-328	IN	denotes	in
T2596	329-341	NN	denotes	pigmentation
T2597	342-345	MD	denotes	can
T2598	356-367	NNS	denotes	differences
T2599	368-370	IN	denotes	in
T2600	371-374	DT	denotes	the
T2601	375-381	NN	denotes	number
T2602	382-385	CC	denotes	and
T2603	385-386	HYPH	denotes	/
T2604	386-388	CC	denotes	or
T2605	389-403	VBN	denotes	differentiated
T2606	404-409	NN	denotes	state
T2607	410-412	IN	denotes	of
T2608	413-420	NN	denotes	pigment
T2609	421-426	NNS	denotes	cells
T2610	426-428	,	denotes	,
T2611	428-430	RB	denotes	as
T2612	436-438	IN	denotes	as
T2613	431-435	RB	denotes	well
T2614	439-442	DT	denotes	the
T2615	443-447	NN	denotes	type
T2616	448-450	IN	denotes	of
T2617	451-458	NN	denotes	pigment
T2618	459-470	VBN	denotes	synthesized
T2619	471-473	IN	denotes	in
T2620	474-482	NN	denotes	response
T2621	483-485	IN	denotes	to
T2622	486-496	NN	denotes	expression
T2623	497-499	IN	denotes	of
T2624	500-506	NN	denotes	Agouti
T2625	506-507	.	denotes	.
T2626	507-677	sentence	denotes	In particular, ventral hair of at/at animals can vary from cream-colored to reddish-yellow depending on age, strain background, and position along the dorsoventral axis.
T2627	508-510	IN	denotes	In
T2628	557-561	VB	denotes	vary
T2629	511-521	JJ	denotes	particular
T2630	521-523	,	denotes	,
T2631	523-530	JJ	denotes	ventral
T2632	531-535	NN	denotes	hair
T2633	536-538	IN	denotes	of
T2634	539-541	NN	denotes	at
T2635	542-544	NN	denotes	at
T2636	541-542	HYPH	denotes	/
T2637	545-552	NNS	denotes	animals
T2638	553-556	MD	denotes	can
T2639	562-566	IN	denotes	from
T2640	567-572	NN	denotes	cream
T2641	573-580	VBN	denotes	colored
T2642	572-573	HYPH	denotes	-
T2643	581-583	IN	denotes	to
T2644	584-591	JJ	denotes	reddish
T2645	592-598	JJ	denotes	yellow
T2646	591-592	HYPH	denotes	-
T2647	599-608	VBG	denotes	depending
T2648	609-611	IN	denotes	on
T2649	612-615	NN	denotes	age
T2650	615-617	,	denotes	,
T2651	617-623	NN	denotes	strain
T2652	624-634	NN	denotes	background
T2653	634-636	,	denotes	,
T2654	636-639	CC	denotes	and
T2655	640-648	NN	denotes	position
T2656	649-654	IN	denotes	along
T2657	655-658	DT	denotes	the
T2658	672-676	NN	denotes	axis
T2659	659-671	JJ	denotes	dorsoventral
T2660	676-677	.	denotes	.
T2661	677-799	sentence	denotes	To evaluate the relationship among these components, we compared their features among mice of different Agouti genotypes.
T2662	678-680	TO	denotes	To
T2663	681-689	VB	denotes	evaluate
T2664	734-742	VBD	denotes	compared
T2665	690-693	DT	denotes	the
T2666	694-706	NN	denotes	relationship
T2667	707-712	IN	denotes	among
T2668	713-718	DT	denotes	these
T2669	719-729	NNS	denotes	components
T2670	729-731	,	denotes	,
T2671	731-733	PRP	denotes	we
T2672	743-748	PRP$	denotes	their
T2673	749-757	NNS	denotes	features
T2674	758-763	IN	denotes	among
T2675	764-768	NNS	denotes	mice
T2676	769-771	IN	denotes	of
T2677	772-781	JJ	denotes	different
T2678	789-798	NNS	denotes	genotypes
T2679	782-788	NN	denotes	Agouti
T2680	798-799	.	denotes	.
T2681	799-1081	sentence	denotes	Semiquantitative measurements of hair length plotted as a function of dorsoventral position reveal that the apparent sharp boundary between dorsal and ventral pigment compartments in at/at mice coincides with a more gradual change in both hair color and hair length (Figure 1A–1D).
T2682	800-816	JJ	denotes	Semiquantitative
T2683	817-829	NNS	denotes	measurements
T2684	892-898	VBP	denotes	reveal
T2685	830-832	IN	denotes	of
T2686	833-837	NN	denotes	hair
T2687	838-844	NN	denotes	length
T2688	845-852	VBN	denotes	plotted
T2689	853-855	IN	denotes	as
T2690	856-857	DT	denotes	a
T2691	858-866	NN	denotes	function
T2692	867-869	IN	denotes	of
T2693	870-882	JJ	denotes	dorsoventral
T2694	883-891	NN	denotes	position
T2695	899-903	IN	denotes	that
T2696	994-1003	VBZ	denotes	coincides
T2697	904-907	DT	denotes	the
T2698	923-931	NN	denotes	boundary
T2699	908-916	JJ	denotes	apparent
T2700	917-922	JJ	denotes	sharp
T2701	932-939	IN	denotes	between
T2702	940-946	JJ	denotes	dorsal
T2703	967-979	NNS	denotes	compartments
T2704	947-950	CC	denotes	and
T2705	951-958	JJ	denotes	ventral
T2706	959-966	NN	denotes	pigment
T2707	980-982	IN	denotes	in
T2708	983-985	NN	denotes	at
T2709	986-988	NN	denotes	at
T2710	985-986	HYPH	denotes	/
T2711	989-993	NNS	denotes	mice
T2712	1004-1008	IN	denotes	with
T2713	1009-1010	DT	denotes	a
T2714	1024-1030	NN	denotes	change
T2715	1011-1015	RBR	denotes	more
T2716	1016-1023	JJ	denotes	gradual
T2717	1031-1033	IN	denotes	in
T2718	1034-1038	CC	denotes	both
T2719	1044-1049	NN	denotes	color
T2720	1039-1043	NN	denotes	hair
T2721	1050-1053	CC	denotes	and
T2722	1054-1058	NN	denotes	hair
T2723	1059-1065	NN	denotes	length
T2724	1066-1067	-LRB-	denotes	(
T2725	1074-1076	CD	denotes	1A
T2726	1067-1073	NN	denotes	Figure
T2727	1076-1077	SYM	denotes	–
T2728	1077-1079	CD	denotes	1D
T2729	1079-1080	-RRB-	denotes	)
T2730	1080-1081	.	denotes	.
T2731	1081-1313	sentence	denotes	Within the region of transition from dorsum to ventrum (Figure 1B), flank hairs from at/at mice become progressively shorter and exhibit increasing amounts of pheomelanin deposition progressing from the tip to the base of the hair.
T2732	1082-1088	IN	denotes	Within
T2733	1178-1184	VBP	denotes	become
T2734	1089-1092	DT	denotes	the
T2735	1093-1099	NN	denotes	region
T2736	1100-1102	IN	denotes	of
T2737	1103-1113	NN	denotes	transition
T2738	1114-1118	IN	denotes	from
T2739	1119-1125	NN	denotes	dorsum
T2740	1126-1128	IN	denotes	to
T2741	1129-1136	NN	denotes	ventrum
T2742	1137-1138	-LRB-	denotes	(
T2743	1138-1144	NN	denotes	Figure
T2744	1145-1147	CD	denotes	1B
T2745	1147-1148	-RRB-	denotes	)
T2746	1148-1150	,	denotes	,
T2747	1150-1155	NN	denotes	flank
T2748	1156-1161	NNS	denotes	hairs
T2749	1162-1166	IN	denotes	from
T2750	1167-1169	NN	denotes	at
T2751	1170-1172	NN	denotes	at
T2752	1169-1170	HYPH	denotes	/
T2753	1173-1177	NNS	denotes	mice
T2754	1185-1198	RB	denotes	progressively
T2755	1199-1206	JJR	denotes	shorter
T2756	1207-1210	CC	denotes	and
T2757	1211-1218	VBP	denotes	exhibit
T2758	1219-1229	VBG	denotes	increasing
T2759	1230-1237	NNS	denotes	amounts
T2760	1238-1240	IN	denotes	of
T2761	1241-1252	NN	denotes	pheomelanin
T2762	1253-1263	NN	denotes	deposition
T2763	1264-1275	VBG	denotes	progressing
T2764	1276-1280	IN	denotes	from
T2765	1281-1284	DT	denotes	the
T2766	1285-1288	NN	denotes	tip
T2767	1289-1291	IN	denotes	to
T2768	1292-1295	DT	denotes	the
T2769	1296-1300	NN	denotes	base
T2770	1301-1303	IN	denotes	of
T2771	1304-1307	DT	denotes	the
T2772	1308-1312	NN	denotes	hair
T2773	1312-1313	.	denotes	.
T2774	1313-1450	sentence	denotes	However, the region of transition for hair length is considerably broader than that for pigmentation and independent of Agouti genotype.
T2775	1314-1321	RB	denotes	However
T2776	1364-1366	VBZ	denotes	is
T2777	1321-1323	,	denotes	,
T2778	1323-1326	DT	denotes	the
T2779	1327-1333	NN	denotes	region
T2780	1334-1336	IN	denotes	of
T2781	1337-1347	NN	denotes	transition
T2782	1348-1351	IN	denotes	for
T2783	1352-1356	NN	denotes	hair
T2784	1357-1363	NN	denotes	length
T2785	1367-1379	RB	denotes	considerably
T2786	1380-1387	JJR	denotes	broader
T2787	1388-1392	IN	denotes	than
T2788	1393-1397	DT	denotes	that
T2789	1398-1401	IN	denotes	for
T2790	1402-1414	NN	denotes	pigmentation
T2791	1415-1418	CC	denotes	and
T2792	1419-1430	JJ	denotes	independent
T2793	1431-1433	IN	denotes	of
T2794	1434-1440	NN	denotes	Agouti
T2795	1441-1449	NN	denotes	genotype
T2796	1449-1450	.	denotes	.
T2797	1450-1634	sentence	denotes	Although hair-cycle timing varies along the rostrocaudal axis, measurements of absolute hair length for mice matched for age and rostrocaudal level are remarkably similar (Figure 1D).
T2798	1451-1459	IN	denotes	Although
T2799	1478-1484	VBZ	denotes	varies
T2800	1460-1464	NN	denotes	hair
T2801	1465-1470	NN	denotes	cycle
T2802	1464-1465	HYPH	denotes	-
T2803	1471-1477	NN	denotes	timing
T2804	1599-1602	VBP	denotes	are
T2805	1485-1490	IN	denotes	along
T2806	1491-1494	DT	denotes	the
T2807	1508-1512	NN	denotes	axis
T2808	1495-1507	JJ	denotes	rostrocaudal
T2809	1512-1514	,	denotes	,
T2810	1514-1526	NNS	denotes	measurements
T2811	1527-1529	IN	denotes	of
T2812	1530-1538	JJ	denotes	absolute
T2813	1544-1550	NN	denotes	length
T2814	1539-1543	NN	denotes	hair
T2815	1551-1554	IN	denotes	for
T2816	1555-1559	NNS	denotes	mice
T2817	1560-1567	VBN	denotes	matched
T2818	1568-1571	IN	denotes	for
T2819	1572-1575	NN	denotes	age
T2820	1576-1579	CC	denotes	and
T2821	1580-1592	JJ	denotes	rostrocaudal
T2822	1593-1598	NN	denotes	level
T2823	1603-1613	RB	denotes	remarkably
T2824	1614-1621	JJ	denotes	similar
T2825	1622-1623	-LRB-	denotes	(
T2826	1623-1629	NN	denotes	Figure
T2827	1630-1632	CD	denotes	1D
T2828	1632-1633	-RRB-	denotes	)
T2829	1633-1634	.	denotes	.
T2830	1634-1813	sentence	denotes	Furthermore, measurements of relative hair length for animals of different age, size, and Agouti genotype also are very similar when normalized to body circumference (Figure 1C).
T2831	1635-1646	RB	denotes	Furthermore
T2832	1746-1749	VBP	denotes	are
T2833	1646-1648	,	denotes	,
T2834	1648-1660	NNS	denotes	measurements
T2835	1661-1663	IN	denotes	of
T2836	1664-1672	JJ	denotes	relative
T2837	1678-1684	NN	denotes	length
T2838	1673-1677	NN	denotes	hair
T2839	1685-1688	IN	denotes	for
T2840	1689-1696	NNS	denotes	animals
T2841	1697-1699	IN	denotes	of
T2842	1700-1709	JJ	denotes	different
T2843	1710-1713	NN	denotes	age
T2844	1713-1715	,	denotes	,
T2845	1715-1719	NN	denotes	size
T2846	1719-1721	,	denotes	,
T2847	1721-1724	CC	denotes	and
T2848	1725-1731	NN	denotes	Agouti
T2849	1732-1740	NN	denotes	genotype
T2850	1741-1745	RB	denotes	also
T2851	1750-1754	RB	denotes	very
T2852	1755-1762	JJ	denotes	similar
T2853	1763-1767	WRB	denotes	when
T2854	1768-1778	VBN	denotes	normalized
T2855	1779-1781	IN	denotes	to
T2856	1782-1786	NN	denotes	body
T2857	1787-1800	NN	denotes	circumference
T2858	1801-1802	-LRB-	denotes	(
T2859	1802-1808	NN	denotes	Figure
T2860	1809-1811	CD	denotes	1C
T2861	1811-1812	-RRB-	denotes	)
T2862	1812-1813	.	denotes	.
T2863	1813-2083	sentence	denotes	Taken together, these observations indicate that variation of hair length along the dorsoventral axis is stereotyped and maintained through multiple hair cycles, with a transition in hair length that is gradual and encompasses the pigment-type transition in at/at mice.
T2864	1814-1819	VBN	denotes	Taken
T2865	1849-1857	VBP	denotes	indicate
T2866	1820-1828	RB	denotes	together
T2867	1828-1830	,	denotes	,
T2868	1830-1835	DT	denotes	these
T2869	1836-1848	NNS	denotes	observations
T2870	1858-1862	IN	denotes	that
T2871	1919-1930	VBN	denotes	stereotyped
T2872	1863-1872	NN	denotes	variation
T2873	1873-1875	IN	denotes	of
T2874	1876-1880	NN	denotes	hair
T2875	1881-1887	NN	denotes	length
T2876	1888-1893	IN	denotes	along
T2877	1894-1897	DT	denotes	the
T2878	1911-1915	NN	denotes	axis
T2879	1898-1910	JJ	denotes	dorsoventral
T2880	1916-1918	VBZ	denotes	is
T2881	1931-1934	CC	denotes	and
T2882	1935-1945	VBN	denotes	maintained
T2883	1946-1953	IN	denotes	through
T2884	1954-1962	JJ	denotes	multiple
T2885	1968-1974	NNS	denotes	cycles
T2886	1963-1967	NN	denotes	hair
T2887	1974-1976	,	denotes	,
T2888	1976-1980	IN	denotes	with
T2889	1981-1982	DT	denotes	a
T2890	1983-1993	NN	denotes	transition
T2891	1994-1996	IN	denotes	in
T2892	1997-2001	NN	denotes	hair
T2893	2002-2008	NN	denotes	length
T2894	2009-2013	WDT	denotes	that
T2895	2014-2016	VBZ	denotes	is
T2896	2017-2024	JJ	denotes	gradual
T2897	2025-2028	CC	denotes	and
T2898	2029-2040	VBZ	denotes	encompasses
T2899	2041-2044	DT	denotes	the
T2900	2058-2068	NN	denotes	transition
T2901	2045-2052	NN	denotes	pigment
T2902	2053-2057	NN	denotes	type
T2903	2052-2053	HYPH	denotes	-
T2904	2069-2071	IN	denotes	in
T2905	2072-2074	NN	denotes	at
T2906	2075-2077	NN	denotes	at
T2907	2074-2075	HYPH	denotes	/
T2908	2078-2082	NNS	denotes	mice
T2909	2082-2083	.	denotes	.
T2910	2083-3281	sentence	denotes	Figure 1 Dorsoventral Skin Characteristics (A) Skin slices from animals of different age and genotype demonstrate similar patterns of hair-length variation along the dorsoventral axis (scale bar = 1 cm). (B) Enlarged area from (A), demonstrating the transition in hair length and color in at/at mice (scale bar = 0.375 cm). (C) Proportional hair length for (A) plotted as a function of relative position along the dorsoventral axis. (D) Hair length plotted as a function of absolute position along the dorsoventral axis for 8-wk-old BA strain mice. (E) Proportion of zigzag hairs (± SEM) differs slightly between dorsum and ventrum of inbred mice (p < 0.0001, χ2 test, n = 1,958, 1,477, 1,579, 1,502). (F) Differences in dorsal and ventral skin development at P4.5 (scale bar = 1 mm, upper; 200 μm, lower). (G) Differences in hair melanin content and DOPA staining for dorsum (d), flank (f), and ventrum (v) in ae/ae and at/at mice. The upper panel also demonstrates a cream-colored appearance of the at/at ventrum. The middle panel shows representative awls (scale bar = 100 μm). The lower panel shows DOPA-stained dermis (scale bar = 200 μm). Dorsal and ventral skin develop at different rates.
T2911	3230-3236	JJ	denotes	Dorsal
T2912	3249-3253	NN	denotes	skin
T2913	3237-3240	CC	denotes	and
T2914	3241-3248	JJ	denotes	ventral
T2915	3254-3261	VBP	denotes	develop
T2916	3262-3264	IN	denotes	at
T2917	3265-3274	JJ	denotes	different
T2918	3275-3280	NNS	denotes	rates
T2919	3280-3281	.	denotes	.
T2920	3281-3507	sentence	denotes	Transverse sections of skin at postnatal day 4.5 (P4.5) exhibit dorsal hair follicles that are noticeably more developed than ventral hair follicles, along with a gradual dorsoventral decrease in dermal thickness (Figure 1F).
T2921	3282-3292	JJ	denotes	Transverse
T2922	3293-3301	NNS	denotes	sections
T2923	3338-3345	VBP	denotes	exhibit
T2924	3302-3304	IN	denotes	of
T2925	3305-3309	NN	denotes	skin
T2926	3310-3312	IN	denotes	at
T2927	3313-3322	JJ	denotes	postnatal
T2928	3323-3326	NN	denotes	day
T2929	3327-3330	CD	denotes	4.5
T2930	3331-3332	-LRB-	denotes	(
T2931	3332-3336	NN	denotes	P4.5
T2932	3336-3337	-RRB-	denotes	)
T2933	3346-3352	JJ	denotes	dorsal
T2934	3358-3367	NNS	denotes	follicles
T2935	3353-3357	NN	denotes	hair
T2936	3368-3372	WDT	denotes	that
T2937	3373-3376	VBP	denotes	are
T2938	3377-3387	RB	denotes	noticeably
T2939	3393-3402	JJ	denotes	developed
T2940	3388-3392	RBR	denotes	more
T2941	3403-3407	IN	denotes	than
T2942	3408-3415	JJ	denotes	ventral
T2943	3421-3430	NNS	denotes	follicles
T2944	3416-3420	NN	denotes	hair
T2945	3430-3432	,	denotes	,
T2946	3432-3437	IN	denotes	along
T2947	3438-3442	IN	denotes	with
T2948	3443-3444	DT	denotes	a
T2949	3466-3474	NN	denotes	decrease
T2950	3445-3452	JJ	denotes	gradual
T2951	3453-3465	JJ	denotes	dorsoventral
T2952	3475-3477	IN	denotes	in
T2953	3478-3484	JJ	denotes	dermal
T2954	3485-3494	NN	denotes	thickness
T2955	3495-3496	-LRB-	denotes	(
T2956	3496-3502	NN	denotes	Figure
T2957	3503-3505	CD	denotes	1F
T2958	3505-3506	-RRB-	denotes	)
T2959	3506-3507	.	denotes	.
T2960	3507-3704	sentence	denotes	However, differences in skin thickness disappear by 3–4 wk of age (Forsthoefel et al. 1966), and, overall, the proportion of different hair types is also similar in dorsa and ventra of adult mice.
T2961	3508-3515	RB	denotes	However
T2962	3547-3556	VBP	denotes	disappear
T2963	3515-3517	,	denotes	,
T2964	3517-3528	NNS	denotes	differences
T2965	3529-3531	IN	denotes	in
T2966	3532-3536	NN	denotes	skin
T2967	3537-3546	NN	denotes	thickness
T2968	3557-3559	IN	denotes	by
T2969	3560-3561	CD	denotes	3
T2970	3562-3563	CD	denotes	4
T2971	3561-3562	SYM	denotes	–
T2972	3564-3566	NN	denotes	wk
T2973	3567-3569	IN	denotes	of
T2974	3570-3573	NN	denotes	age
T2975	3574-3575	-LRB-	denotes	(
T2976	3575-3586	NNP	denotes	Forsthoefel
T2977	3587-3589	FW	denotes	et
T2978	3590-3593	FW	denotes	al.
T2979	3594-3598	CD	denotes	1966
T2980	3598-3599	-RRB-	denotes	)
T2981	3599-3601	,	denotes	,
T2982	3601-3604	CC	denotes	and
T2983	3604-3606	,	denotes	,
T2984	3606-3613	RB	denotes	overall
T2985	3654-3656	VBZ	denotes	is
T2986	3613-3615	,	denotes	,
T2987	3615-3618	DT	denotes	the
T2988	3619-3629	NN	denotes	proportion
T2989	3630-3632	IN	denotes	of
T2990	3633-3642	JJ	denotes	different
T2991	3648-3653	NNS	denotes	types
T2992	3643-3647	NN	denotes	hair
T2993	3657-3661	RB	denotes	also
T2994	3662-3669	JJ	denotes	similar
T2995	3670-3672	IN	denotes	in
T2996	3673-3678	NNS	denotes	dorsa
T2997	3679-3682	CC	denotes	and
T2998	3683-3689	NNS	denotes	ventra
T2999	3690-3692	IN	denotes	of
T3000	3693-3698	JJ	denotes	adult
T3001	3699-3703	NNS	denotes	mice
T3002	3703-3704	.	denotes	.
T3003	3704-3998	sentence	denotes	In age-matched inbred mice, we observed a small decrease in the ratio of undercoat hairs (zigzags) to overcoat hairs (auchenes, awls, and guard hairs) in dorsum compared to ventrum (Figure 1E), but there was no consistent difference in hair-type distribution for outbred mice (data not shown).
T3004	3705-3707	IN	denotes	In
T3005	3736-3744	VBD	denotes	observed
T3006	3708-3711	NN	denotes	age
T3007	3712-3719	VBN	denotes	matched
T3008	3711-3712	HYPH	denotes	-
T3009	3727-3731	NNS	denotes	mice
T3010	3720-3726	JJ	denotes	inbred
T3011	3731-3733	,	denotes	,
T3012	3733-3735	PRP	denotes	we
T3013	3745-3746	DT	denotes	a
T3014	3753-3761	NN	denotes	decrease
T3015	3747-3752	JJ	denotes	small
T3016	3762-3764	IN	denotes	in
T3017	3765-3768	DT	denotes	the
T3018	3769-3774	NN	denotes	ratio
T3019	3775-3777	IN	denotes	of
T3020	3778-3787	NN	denotes	undercoat
T3021	3788-3793	NNS	denotes	hairs
T3022	3794-3795	-LRB-	denotes	(
T3023	3795-3802	NNS	denotes	zigzags
T3024	3802-3803	-RRB-	denotes	)
T3025	3804-3806	IN	denotes	to
T3026	3807-3815	NN	denotes	overcoat
T3027	3816-3821	NNS	denotes	hairs
T3028	3822-3823	-LRB-	denotes	(
T3029	3823-3831	NNS	denotes	auchenes
T3030	3831-3833	,	denotes	,
T3031	3833-3837	NNS	denotes	awls
T3032	3837-3839	,	denotes	,
T3033	3839-3842	CC	denotes	and
T3034	3843-3848	NN	denotes	guard
T3035	3849-3854	NNS	denotes	hairs
T3036	3854-3855	-RRB-	denotes	)
T3037	3856-3858	IN	denotes	in
T3038	3859-3865	NN	denotes	dorsum
T3039	3866-3874	VBN	denotes	compared
T3040	3875-3877	IN	denotes	to
T3041	3878-3885	NN	denotes	ventrum
T3042	3886-3887	-LRB-	denotes	(
T3043	3887-3893	NN	denotes	Figure
T3044	3894-3896	CD	denotes	1E
T3045	3896-3897	-RRB-	denotes	)
T3046	3897-3899	,	denotes	,
T3047	3899-3902	CC	denotes	but
T3048	3903-3908	EX	denotes	there
T3049	3909-3912	VBD	denotes	was
T3050	3913-3915	DT	denotes	no
T3051	3927-3937	NN	denotes	difference
T3052	3916-3926	JJ	denotes	consistent
T3053	3938-3940	IN	denotes	in
T3054	3941-3945	NN	denotes	hair
T3055	3946-3950	NN	denotes	type
T3056	3945-3946	HYPH	denotes	-
T3057	3951-3963	NN	denotes	distribution
T3058	3964-3967	IN	denotes	for
T3059	3968-3975	JJ	denotes	outbred
T3060	3976-3980	NNS	denotes	mice
T3061	3981-3982	-LRB-	denotes	(
T3062	3991-3996	VBN	denotes	shown
T3063	3982-3986	NNS	denotes	data
T3064	3987-3990	RB	denotes	not
T3065	3996-3997	-RRB-	denotes	)
T3066	3997-3998	.	denotes	.
T3067	3998-4372	sentence	denotes	Differences between dorsal and ventral pigmentation of at/at mice are usually attributed to pigment-type differences caused by ventral-specific expression of Agouti, but animals homozygous for a null allele of Agouti, extreme nonagouti (ae), have ventral hairs that contain less melanin than dorsal hairs, giving a slightly paler appearance to the ventral coat (Figure 1G).
T3068	3999-4010	NNS	denotes	Differences
T3069	4077-4087	VBN	denotes	attributed
T3070	4011-4018	IN	denotes	between
T3071	4019-4025	JJ	denotes	dorsal
T3072	4038-4050	NN	denotes	pigmentation
T3073	4026-4029	CC	denotes	and
T3074	4030-4037	JJ	denotes	ventral
T3075	4051-4053	IN	denotes	of
T3076	4054-4056	NN	denotes	at
T3077	4057-4059	NN	denotes	at
T3078	4056-4057	HYPH	denotes	/
T3079	4060-4064	NNS	denotes	mice
T3080	4065-4068	VBP	denotes	are
T3081	4069-4076	RB	denotes	usually
T3082	4088-4090	IN	denotes	to
T3083	4091-4098	NN	denotes	pigment
T3084	4099-4103	NN	denotes	type
T3085	4098-4099	HYPH	denotes	-
T3086	4104-4115	NNS	denotes	differences
T3087	4116-4122	VBN	denotes	caused
T3088	4123-4125	IN	denotes	by
T3089	4126-4133	JJ	denotes	ventral
T3090	4134-4142	JJ	denotes	specific
T3091	4133-4134	HYPH	denotes	-
T3092	4143-4153	NN	denotes	expression
T3093	4154-4156	IN	denotes	of
T3094	4157-4163	NN	denotes	Agouti
T3095	4163-4165	,	denotes	,
T3096	4165-4168	CC	denotes	but
T3097	4169-4176	NNS	denotes	animals
T3098	4241-4245	VBP	denotes	have
T3099	4177-4187	JJ	denotes	homozygous
T3100	4188-4191	IN	denotes	for
T3101	4192-4193	DT	denotes	a
T3102	4199-4205	NN	denotes	allele
T3103	4194-4198	JJ	denotes	null
T3104	4206-4208	IN	denotes	of
T3105	4209-4215	NN	denotes	Agouti
T3106	4215-4217	,	denotes	,
T3107	4217-4224	JJ	denotes	extreme
T3108	4225-4234	NN	denotes	nonagouti
T3109	4235-4236	-LRB-	denotes	(
T3110	4236-4238	NN	denotes	ae
T3111	4238-4239	-RRB-	denotes	)
T3112	4239-4241	,	denotes	,
T3113	4246-4253	JJ	denotes	ventral
T3114	4254-4259	NNS	denotes	hairs
T3115	4260-4264	WDT	denotes	that
T3116	4265-4272	VBP	denotes	contain
T3117	4273-4277	JJR	denotes	less
T3118	4278-4285	NN	denotes	melanin
T3119	4286-4290	IN	denotes	than
T3120	4291-4297	JJ	denotes	dorsal
T3121	4298-4303	NNS	denotes	hairs
T3122	4303-4305	,	denotes	,
T3123	4305-4311	VBG	denotes	giving
T3124	4312-4313	DT	denotes	a
T3125	4329-4339	NN	denotes	appearance
T3126	4314-4322	RB	denotes	slightly
T3127	4323-4328	JJ	denotes	paler
T3128	4340-4342	IN	denotes	to
T3129	4343-4346	DT	denotes	the
T3130	4355-4359	NN	denotes	coat
T3131	4347-4354	JJ	denotes	ventral
T3132	4360-4361	-LRB-	denotes	(
T3133	4361-4367	NN	denotes	Figure
T3134	4368-4370	CD	denotes	1G
T3135	4370-4371	-RRB-	denotes	)
T3136	4371-4372	.	denotes	.
T3137	4372-4544	sentence	denotes	Using DOPA staining as an indicator of tyrosinase activity, we observed a gradual dorsoventral transition in isolated dermis preparations from P4.5 ae/ae mice (Figure 1G).
T3138	4373-4378	VBG	denotes	Using
T3139	4436-4444	VBD	denotes	observed
T3140	4379-4383	NN	denotes	DOPA
T3141	4384-4392	NN	denotes	staining
T3142	4393-4395	IN	denotes	as
T3143	4396-4398	DT	denotes	an
T3144	4399-4408	NN	denotes	indicator
T3145	4409-4411	IN	denotes	of
T3146	4412-4422	NN	denotes	tyrosinase
T3147	4423-4431	NN	denotes	activity
T3148	4431-4433	,	denotes	,
T3149	4433-4435	PRP	denotes	we
T3150	4445-4446	DT	denotes	a
T3151	4468-4478	NN	denotes	transition
T3152	4447-4454	JJ	denotes	gradual
T3153	4455-4467	JJ	denotes	dorsoventral
T3154	4479-4481	IN	denotes	in
T3155	4482-4490	VBN	denotes	isolated
T3156	4498-4510	NNS	denotes	preparations
T3157	4491-4497	NN	denotes	dermis
T3158	4511-4515	IN	denotes	from
T3159	4516-4520	NN	denotes	P4.5
T3160	4527-4531	NNS	denotes	mice
T3161	4521-4523	NN	denotes	ae
T3162	4524-4526	NN	denotes	ae
T3163	4523-4524	HYPH	denotes	/
T3164	4532-4533	-LRB-	denotes	(
T3165	4533-4539	NN	denotes	Figure
T3166	4540-4542	CD	denotes	1G
T3167	4542-4543	-RRB-	denotes	)
T3168	4543-4544	.	denotes	.
T3169	4544-4789	sentence	denotes	By contrast, skin from at/at mice reveal an abrupt dorsoventral transition of DOPA staining, which probably reflects the additive effects of reduced melanin content (as in ae/ae mice) and downregulation of tyrosinase activity induced by Agouti.
T3170	4545-4547	IN	denotes	By
T3171	4579-4585	VBP	denotes	reveal
T3172	4548-4556	NN	denotes	contrast
T3173	4556-4558	,	denotes	,
T3174	4558-4562	NN	denotes	skin
T3175	4563-4567	IN	denotes	from
T3176	4568-4570	NN	denotes	at
T3177	4571-4573	NN	denotes	at
T3178	4570-4571	HYPH	denotes	/
T3179	4574-4578	NNS	denotes	mice
T3180	4586-4588	DT	denotes	an
T3181	4609-4619	NN	denotes	transition
T3182	4589-4595	JJ	denotes	abrupt
T3183	4596-4608	JJ	denotes	dorsoventral
T3184	4620-4622	IN	denotes	of
T3185	4623-4627	NN	denotes	DOPA
T3186	4628-4636	NN	denotes	staining
T3187	4636-4638	,	denotes	,
T3188	4638-4643	WDT	denotes	which
T3189	4653-4661	VBZ	denotes	reflects
T3190	4644-4652	RB	denotes	probably
T3191	4662-4665	DT	denotes	the
T3192	4675-4682	NNS	denotes	effects
T3193	4666-4674	JJ	denotes	additive
T3194	4683-4685	IN	denotes	of
T3195	4686-4693	VBN	denotes	reduced
T3196	4702-4709	NN	denotes	content
T3197	4694-4701	NN	denotes	melanin
T3198	4710-4711	-LRB-	denotes	(
T3199	4711-4713	IN	denotes	as
T3200	4714-4716	IN	denotes	in
T3201	4717-4719	NN	denotes	ae
T3202	4720-4722	NN	denotes	ae
T3203	4719-4720	HYPH	denotes	/
T3204	4723-4727	NNS	denotes	mice
T3205	4727-4728	-RRB-	denotes	)
T3206	4729-4732	CC	denotes	and
T3207	4733-4747	NN	denotes	downregulation
T3208	4748-4750	IN	denotes	of
T3209	4751-4761	NN	denotes	tyrosinase
T3210	4762-4770	NN	denotes	activity
T3211	4771-4778	VBN	denotes	induced
T3212	4779-4781	IN	denotes	by
T3213	4782-4788	NN	denotes	Agouti
T3214	4788-4789	.	denotes	.
T3215	4789-4922	sentence	denotes	Melanin content of individual hairs is likely to be influenced both by the number of pigment cells and their follicular environment.
T3216	4790-4797	NN	denotes	Melanin
T3217	4798-4805	NN	denotes	content
T3218	4826-4828	VBZ	denotes	is
T3219	4806-4808	IN	denotes	of
T3220	4809-4819	JJ	denotes	individual
T3221	4820-4825	NNS	denotes	hairs
T3222	4829-4835	JJ	denotes	likely
T3223	4836-4838	TO	denotes	to
T3224	4842-4852	VBN	denotes	influenced
T3225	4839-4841	VB	denotes	be
T3226	4853-4857	CC	denotes	both
T3227	4858-4860	IN	denotes	by
T3228	4861-4864	DT	denotes	the
T3229	4865-4871	NN	denotes	number
T3230	4872-4874	IN	denotes	of
T3231	4875-4882	NN	denotes	pigment
T3232	4883-4888	NNS	denotes	cells
T3233	4889-4892	CC	denotes	and
T3234	4893-4898	PRP$	denotes	their
T3235	4910-4921	NN	denotes	environment
T3236	4899-4909	JJ	denotes	follicular
T3237	4921-4922	.	denotes	.
T3238	4922-5105	sentence	denotes	Regardless, dorsoventral differences in hair pigment content of ae/ae mice persist throughout multiple hair cycles into adulthood, similar to hair length (but unlike skin thickness).
T3239	4923-4933	RB	denotes	Regardless
T3240	4998-5005	VBP	denotes	persist
T3241	4933-4935	,	denotes	,
T3242	4935-4947	JJ	denotes	dorsoventral
T3243	4948-4959	NNS	denotes	differences
T3244	4960-4962	IN	denotes	in
T3245	4963-4967	NN	denotes	hair
T3246	4976-4983	NN	denotes	content
T3247	4968-4975	NN	denotes	pigment
T3248	4984-4986	IN	denotes	of
T3249	4987-4989	NN	denotes	ae
T3250	4990-4992	NN	denotes	ae
T3251	4989-4990	HYPH	denotes	/
T3252	4993-4997	NNS	denotes	mice
T3253	5006-5016	IN	denotes	throughout
T3254	5017-5025	JJ	denotes	multiple
T3255	5031-5037	NNS	denotes	cycles
T3256	5026-5030	NN	denotes	hair
T3257	5038-5042	IN	denotes	into
T3258	5043-5052	NN	denotes	adulthood
T3259	5052-5054	,	denotes	,
T3260	5054-5061	JJ	denotes	similar
T3261	5062-5064	IN	denotes	to
T3262	5065-5069	NN	denotes	hair
T3263	5070-5076	NN	denotes	length
T3264	5077-5078	-LRB-	denotes	(
T3265	5078-5081	CC	denotes	but
T3266	5082-5088	IN	denotes	unlike
T3267	5089-5093	NN	denotes	skin
T3268	5094-5103	NN	denotes	thickness
T3269	5103-5104	-RRB-	denotes	)
T3270	5104-5105	.	denotes	.
T3271	5105-5314	sentence	denotes	Thus, at least three characteristics distinguish dorsal from ventral skin: differences in pigment-type synthesis (depending on Agouti genotype), differences in hair length, and differences in melanin content.
T3272	5106-5110	RB	denotes	Thus
T3273	5143-5154	VBP	denotes	distinguish
T3274	5110-5112	,	denotes	,
T3275	5112-5114	RB	denotes	at
T3276	5121-5126	CD	denotes	three
T3277	5115-5120	RBS	denotes	least
T3278	5127-5142	NNS	denotes	characteristics
T3279	5155-5161	JJ	denotes	dorsal
T3280	5162-5166	IN	denotes	from
T3281	5167-5174	JJ	denotes	ventral
T3282	5175-5179	NN	denotes	skin
T3283	5179-5181	:	denotes	:
T3284	5181-5192	NNS	denotes	differences
T3285	5193-5195	IN	denotes	in
T3286	5196-5203	NN	denotes	pigment
T3287	5204-5208	NN	denotes	type
T3288	5203-5204	HYPH	denotes	-
T3289	5209-5218	NN	denotes	synthesis
T3290	5219-5220	-LRB-	denotes	(
T3291	5220-5229	VBG	denotes	depending
T3292	5230-5232	IN	denotes	on
T3293	5233-5239	NN	denotes	Agouti
T3294	5240-5248	NN	denotes	genotype
T3295	5248-5249	-RRB-	denotes	)
T3296	5249-5251	,	denotes	,
T3297	5251-5262	NNS	denotes	differences
T3298	5263-5265	IN	denotes	in
T3299	5266-5270	NN	denotes	hair
T3300	5271-5277	NN	denotes	length
T3301	5277-5279	,	denotes	,
T3302	5279-5282	CC	denotes	and
T3303	5283-5294	NNS	denotes	differences
T3304	5295-5297	IN	denotes	in
T3305	5298-5305	NN	denotes	melanin
T3306	5306-5313	NN	denotes	content
T3307	5313-5314	.	denotes	.
T3535	5316-5330	NN	denotes	Ventralization
T3536	5331-5333	IN	denotes	of
T3537	5334-5338	NN	denotes	Skin
T3538	5339-5349	NN	denotes	Morphology
T3539	5350-5352	IN	denotes	by
T3540	5353-5356	DT	denotes	the
T3541	5368-5376	NN	denotes	Mutation
T3542	5357-5363	JJ	denotes	droopy
T3543	5364-5367	NN	denotes	ear
T3544	5376-5707	sentence	denotes	Named after its effects on craniofacial morphology, droopy ear is a recessive mutation on mouse Chromosome 3; the original allele described more than 40 years ago by Curry (1959) is extinct, but a spontaneous remutation that occurred in Harwell, deH, is available through The Jackson Laboratory (Bar Harbor, Maine, United States).
T3545	5377-5382	VBN	denotes	Named
T3546	5440-5442	VBZ	denotes	is
T3547	5383-5388	IN	denotes	after
T3548	5389-5392	PRP$	denotes	its
T3549	5393-5400	NNS	denotes	effects
T3550	5401-5403	IN	denotes	on
T3551	5404-5416	JJ	denotes	craniofacial
T3552	5417-5427	NN	denotes	morphology
T3553	5427-5429	,	denotes	,
T3554	5429-5435	JJ	denotes	droopy
T3555	5436-5439	NN	denotes	ear
T3556	5556-5558	VBZ	denotes	is
T3557	5443-5444	DT	denotes	a
T3558	5455-5463	NN	denotes	mutation
T3559	5445-5454	JJ	denotes	recessive
T3560	5464-5466	IN	denotes	on
T3561	5467-5472	NN	denotes	mouse
T3562	5473-5483	NN	denotes	Chromosome
T3563	5484-5485	CD	denotes	3
T3564	5485-5486	:	denotes	;
T3565	5487-5490	DT	denotes	the
T3566	5500-5506	NN	denotes	allele
T3567	5491-5499	JJ	denotes	original
T3568	5507-5516	VBN	denotes	described
T3569	5517-5521	JJR	denotes	more
T3570	5527-5529	CD	denotes	40
T3571	5522-5526	IN	denotes	than
T3572	5530-5535	NNS	denotes	years
T3573	5536-5539	RB	denotes	ago
T3574	5540-5542	IN	denotes	by
T3575	5543-5548	NNP	denotes	Curry
T3576	5549-5550	-LRB-	denotes	(
T3577	5550-5554	CD	denotes	1959
T3578	5554-5555	-RRB-	denotes	)
T3579	5559-5566	JJ	denotes	extinct
T3580	5566-5568	,	denotes	,
T3581	5568-5571	CC	denotes	but
T3582	5572-5573	DT	denotes	a
T3583	5586-5596	NN	denotes	remutation
T3584	5574-5585	JJ	denotes	spontaneous
T3585	5628-5630	VBZ	denotes	is
T3586	5597-5601	WDT	denotes	that
T3587	5602-5610	VBD	denotes	occurred
T3588	5611-5613	IN	denotes	in
T3589	5614-5621	NNP	denotes	Harwell
T3590	5621-5623	,	denotes	,
T3591	5623-5626	NN	denotes	deH
T3592	5626-5628	,	denotes	,
T3593	5631-5640	JJ	denotes	available
T3594	5641-5648	IN	denotes	through
T3595	5649-5652	DT	denotes	The
T3596	5661-5671	NNP	denotes	Laboratory
T3597	5653-5660	NNP	denotes	Jackson
T3598	5672-5673	-LRB-	denotes	(
T3599	5677-5683	NNP	denotes	Harbor
T3600	5673-5676	NNP	denotes	Bar
T3601	5683-5685	,	denotes	,
T3602	5685-5690	NNP	denotes	Maine
T3603	5690-5692	,	denotes	,
T3604	5692-5698	NNP	denotes	United
T3605	5699-5705	NNP	denotes	States
T3606	5705-5706	-RRB-	denotes	)
T3607	5706-5707	.	denotes	.
T3608	5707-6004	sentence	denotes	External craniofacial malformations are the most obvious characteristic of deH/deH animals, including widely spaced eyes, small palpebral fissures, a broad nasal area, and a shortened skull held in an elevated position, which presumably causes or contributes to the abnormal position of the ears.
T3609	5708-5716	JJ	denotes	External
T3610	5730-5743	NNS	denotes	malformations
T3611	5717-5729	JJ	denotes	craniofacial
T3612	5744-5747	VBP	denotes	are
T3613	5748-5751	DT	denotes	the
T3614	5765-5779	NN	denotes	characteristic
T3615	5752-5756	RBS	denotes	most
T3616	5757-5764	JJ	denotes	obvious
T3617	5780-5782	IN	denotes	of
T3618	5783-5786	NN	denotes	deH
T3619	5787-5790	NN	denotes	deH
T3620	5786-5787	HYPH	denotes	/
T3621	5791-5798	NNS	denotes	animals
T3622	5798-5800	,	denotes	,
T3623	5800-5809	VBG	denotes	including
T3624	5810-5816	RB	denotes	widely
T3625	5817-5823	VBN	denotes	spaced
T3626	5824-5828	NNS	denotes	eyes
T3627	5828-5830	,	denotes	,
T3628	5830-5835	JJ	denotes	small
T3629	5846-5854	NNS	denotes	fissures
T3630	5836-5845	JJ	denotes	palpebral
T3631	5854-5856	,	denotes	,
T3632	5856-5857	DT	denotes	a
T3633	5870-5874	NN	denotes	area
T3634	5858-5863	JJ	denotes	broad
T3635	5864-5869	JJ	denotes	nasal
T3636	5874-5876	,	denotes	,
T3637	5876-5879	CC	denotes	and
T3638	5880-5881	DT	denotes	a
T3639	5892-5897	NN	denotes	skull
T3640	5882-5891	JJ	denotes	shortened
T3641	5898-5902	VBN	denotes	held
T3642	5903-5905	IN	denotes	in
T3643	5906-5908	DT	denotes	an
T3644	5918-5926	NN	denotes	position
T3645	5909-5917	JJ	denotes	elevated
T3646	5926-5928	,	denotes	,
T3647	5928-5933	WDT	denotes	which
T3648	5945-5951	VBZ	denotes	causes
T3649	5934-5944	RB	denotes	presumably
T3650	5952-5954	CC	denotes	or
T3651	5955-5966	VBZ	denotes	contributes
T3652	5967-5969	IN	denotes	to
T3653	5970-5973	DT	denotes	the
T3654	5983-5991	NN	denotes	position
T3655	5974-5982	JJ	denotes	abnormal
T3656	5992-5994	IN	denotes	of
T3657	5995-5998	DT	denotes	the
T3658	5999-6003	NNS	denotes	ears
T3659	6003-6004	.	denotes	.
T3660	6004-6358	sentence	denotes	We became interested in droopy ear because the original allele was described to affect pigment pattern in a way that suggests a possible dorsal to ventral transformation: “On a genetic background (at and AW) which causes the belly hair to be lighter than the back hair, the belly hair comes up farther round the sides of the body and face” (Curry 1959).
T3661	6005-6007	PRP	denotes	We
T3662	6008-6014	VBD	denotes	became
T3663	6290-6295	VBZ	denotes	comes
T3664	6015-6025	JJ	denotes	interested
T3665	6026-6028	IN	denotes	in
T3666	6029-6035	JJ	denotes	droopy
T3667	6036-6039	NN	denotes	ear
T3668	6040-6047	IN	denotes	because
T3669	6072-6081	VBN	denotes	described
T3670	6048-6051	DT	denotes	the
T3671	6061-6067	NN	denotes	allele
T3672	6052-6060	JJ	denotes	original
T3673	6068-6071	VBD	denotes	was
T3674	6082-6084	TO	denotes	to
T3675	6085-6091	VB	denotes	affect
T3676	6092-6099	NN	denotes	pigment
T3677	6100-6107	NN	denotes	pattern
T3678	6108-6110	IN	denotes	in
T3679	6111-6112	DT	denotes	a
T3680	6113-6116	NN	denotes	way
T3681	6117-6121	WDT	denotes	that
T3682	6122-6130	VBZ	denotes	suggests
T3683	6131-6132	DT	denotes	a
T3684	6160-6174	NN	denotes	transformation
T3685	6133-6141	JJ	denotes	possible
T3686	6142-6148	JJ	denotes	dorsal
T3687	6149-6151	IN	denotes	to
T3688	6152-6159	JJ	denotes	ventral
T3689	6174-6176	:	denotes	:
T3690	6176-6177	``	denotes	“
T3691	6177-6179	IN	denotes	On
T3692	6180-6181	DT	denotes	a
T3693	6190-6200	NN	denotes	background
T3694	6182-6189	JJ	denotes	genetic
T3695	6201-6202	-LRB-	denotes	(
T3696	6202-6204	NN	denotes	at
T3697	6205-6208	CC	denotes	and
T3698	6209-6211	NN	denotes	AW
T3699	6211-6212	-RRB-	denotes	)
T3700	6213-6218	WDT	denotes	which
T3701	6219-6225	VBZ	denotes	causes
T3702	6226-6229	DT	denotes	the
T3703	6236-6240	NN	denotes	hair
T3704	6230-6235	NN	denotes	belly
T3705	6244-6246	VB	denotes	be
T3706	6241-6243	TO	denotes	to
T3707	6247-6254	JJR	denotes	lighter
T3708	6255-6259	IN	denotes	than
T3709	6260-6263	DT	denotes	the
T3710	6269-6273	NN	denotes	hair
T3711	6264-6268	NN	denotes	back
T3712	6273-6275	,	denotes	,
T3713	6275-6278	DT	denotes	the
T3714	6285-6289	NN	denotes	hair
T3715	6279-6284	NN	denotes	belly
T3716	6296-6298	RP	denotes	up
T3717	6299-6306	RBR	denotes	farther
T3718	6307-6312	IN	denotes	round
T3719	6313-6316	DT	denotes	the
T3720	6317-6322	NNS	denotes	sides
T3721	6323-6325	IN	denotes	of
T3722	6326-6329	DT	denotes	the
T3723	6330-6334	NN	denotes	body
T3724	6335-6338	CC	denotes	and
T3725	6339-6343	NN	denotes	face
T3726	6343-6344	''	denotes	”
T3727	6345-6346	-LRB-	denotes	(
T3728	6346-6351	NNP	denotes	Curry
T3729	6352-6356	CD	denotes	1959
T3730	6356-6357	-RRB-	denotes	)
T3731	6357-6358	.	denotes	.
T3732	6358-6578	sentence	denotes	An abnormal dorsoventral pigment pattern is readily apparent in at/at; deH/deH mice, but comparison to nonmutant animals is more accurately described in terms of ventral, lateral, and dorsal regions (Figures 1G and 2A).
T3733	6359-6361	DT	denotes	An
T3734	6392-6399	NN	denotes	pattern
T3735	6362-6370	JJ	denotes	abnormal
T3736	6371-6383	JJ	denotes	dorsoventral
T3737	6384-6391	NN	denotes	pigment
T3738	6400-6402	VBZ	denotes	is
T3739	6403-6410	RB	denotes	readily
T3740	6411-6419	JJ	denotes	apparent
T3741	6420-6422	IN	denotes	in
T3742	6423-6425	NN	denotes	at
T3743	6426-6428	NN	denotes	at
T3744	6425-6426	HYPH	denotes	/
T3745	6438-6442	NNS	denotes	mice
T3746	6428-6429	,	denotes	;
T3747	6430-6433	NN	denotes	deH
T3748	6434-6437	NN	denotes	deH
T3749	6433-6434	HYPH	denotes	/
T3750	6442-6444	,	denotes	,
T3751	6444-6447	CC	denotes	but
T3752	6448-6458	NN	denotes	comparison
T3753	6499-6508	VBN	denotes	described
T3754	6459-6461	IN	denotes	to
T3755	6462-6471	JJ	denotes	nonmutant
T3756	6472-6479	NNS	denotes	animals
T3757	6480-6482	VBZ	denotes	is
T3758	6483-6487	RBR	denotes	more
T3759	6488-6498	RB	denotes	accurately
T3760	6509-6511	IN	denotes	in
T3761	6512-6517	NNS	denotes	terms
T3762	6518-6520	IN	denotes	of
T3763	6521-6528	JJ	denotes	ventral
T3764	6550-6557	NNS	denotes	regions
T3765	6528-6530	,	denotes	,
T3766	6530-6537	JJ	denotes	lateral
T3767	6537-6539	,	denotes	,
T3768	6539-6542	CC	denotes	and
T3769	6543-6549	JJ	denotes	dorsal
T3770	6558-6559	-LRB-	denotes	(
T3771	6567-6569	CD	denotes	1G
T3772	6559-6566	NNS	denotes	Figures
T3773	6570-6573	CC	denotes	and
T3774	6574-6576	CD	denotes	2A
T3775	6576-6577	-RRB-	denotes	)
T3776	6577-6578	.	denotes	.
T3777	6578-6843	sentence	denotes	The ventral region has short hairs with a gray base and cream-colored tip whose boundary coincides with the limb–body wall junction; both the appearance of this region and position of the boundary are approximately similar in at/at compared to at/at; deH/deH mice.
T3778	6579-6582	DT	denotes	The
T3779	6591-6597	NN	denotes	region
T3780	6583-6590	JJ	denotes	ventral
T3781	6598-6601	VBZ	denotes	has
T3782	6776-6779	VBP	denotes	are
T3783	6602-6607	JJ	denotes	short
T3784	6608-6613	NNS	denotes	hairs
T3785	6614-6618	IN	denotes	with
T3786	6619-6620	DT	denotes	a
T3787	6626-6630	NN	denotes	base
T3788	6621-6625	JJ	denotes	gray
T3789	6631-6634	CC	denotes	and
T3790	6635-6640	NN	denotes	cream
T3791	6641-6648	VBN	denotes	colored
T3792	6640-6641	HYPH	denotes	-
T3793	6649-6652	NN	denotes	tip
T3794	6653-6658	WP$	denotes	whose
T3795	6659-6667	NN	denotes	boundary
T3796	6668-6677	VBZ	denotes	coincides
T3797	6678-6682	IN	denotes	with
T3798	6683-6686	DT	denotes	the
T3799	6702-6710	NN	denotes	junction
T3800	6687-6691	NN	denotes	limb
T3801	6692-6696	NN	denotes	body
T3802	6691-6692	HYPH	denotes	–
T3803	6697-6701	NN	denotes	wall
T3804	6710-6711	:	denotes	;
T3805	6712-6716	CC	denotes	both
T3806	6721-6731	NN	denotes	appearance
T3807	6717-6720	DT	denotes	the
T3808	6732-6734	IN	denotes	of
T3809	6735-6739	DT	denotes	this
T3810	6740-6746	NN	denotes	region
T3811	6747-6750	CC	denotes	and
T3812	6751-6759	NN	denotes	position
T3813	6760-6762	IN	denotes	of
T3814	6763-6766	DT	denotes	the
T3815	6767-6775	NN	denotes	boundary
T3816	6780-6793	RB	denotes	approximately
T3817	6794-6801	JJ	denotes	similar
T3818	6802-6804	IN	denotes	in
T3819	6805-6807	NN	denotes	at
T3820	6808-6810	NN	denotes	at
T3821	6807-6808	HYPH	denotes	/
T3822	6838-6842	NNS	denotes	mice
T3823	6811-6819	VBN	denotes	compared
T3824	6820-6822	IN	denotes	to
T3825	6823-6825	NN	denotes	at
T3826	6826-6828	NN	denotes	at
T3827	6825-6826	HYPH	denotes	/
T3828	6828-6829	,	denotes	;
T3829	6830-6833	NN	denotes	deH
T3830	6834-6837	NN	denotes	deH
T3831	6833-6834	HYPH	denotes	/
T3832	6842-6843	.	denotes	.
T3833	6843-7211	sentence	denotes	The lateral region contains yellow hairs of progressively increasing length; in at/at mice, the lateral region appears as a thin yellow stripe along the flank, but in at/at; deH/deH mice, the lateral region is considerably expanded with a diffuse boundary along the dorsal flank, and a dorsal eumelanic region whose size is correspondingly reduced (Figure 2A and 2B).
T3834	6844-6847	DT	denotes	The
T3835	6856-6862	NN	denotes	region
T3836	6848-6855	JJ	denotes	lateral
T3837	6863-6871	VBZ	denotes	contains
T3838	6955-6962	VBZ	denotes	appears
T3839	6872-6878	JJ	denotes	yellow
T3840	6879-6884	NNS	denotes	hairs
T3841	6885-6887	IN	denotes	of
T3842	6888-6901	RB	denotes	progressively
T3843	6902-6912	VBG	denotes	increasing
T3844	6913-6919	NN	denotes	length
T3845	6919-6920	:	denotes	;
T3846	6921-6923	IN	denotes	in
T3847	6924-6926	NN	denotes	at
T3848	6927-6929	NN	denotes	at
T3849	6926-6927	HYPH	denotes	/
T3850	6930-6934	NNS	denotes	mice
T3851	6934-6936	,	denotes	,
T3852	6936-6939	DT	denotes	the
T3853	6948-6954	NN	denotes	region
T3854	6940-6947	JJ	denotes	lateral
T3855	6963-6965	IN	denotes	as
T3856	6966-6967	DT	denotes	a
T3857	6980-6986	NN	denotes	stripe
T3858	6968-6972	JJ	denotes	thin
T3859	6973-6979	JJ	denotes	yellow
T3860	6987-6992	IN	denotes	along
T3861	6993-6996	DT	denotes	the
T3862	6997-7002	NN	denotes	flank
T3863	7002-7004	,	denotes	,
T3864	7004-7007	CC	denotes	but
T3865	7008-7010	IN	denotes	in
T3866	7051-7053	VBZ	denotes	is
T3867	7011-7013	NN	denotes	at
T3868	7014-7016	NN	denotes	at
T3869	7013-7014	HYPH	denotes	/
T3870	7026-7030	NNS	denotes	mice
T3871	7016-7017	,	denotes	;
T3872	7018-7021	NN	denotes	deH
T3873	7022-7025	NN	denotes	deH
T3874	7021-7022	HYPH	denotes	/
T3875	7030-7032	,	denotes	,
T3876	7032-7035	DT	denotes	the
T3877	7044-7050	NN	denotes	region
T3878	7036-7043	JJ	denotes	lateral
T3879	7054-7066	RB	denotes	considerably
T3880	7067-7075	JJ	denotes	expanded
T3881	7076-7080	IN	denotes	with
T3882	7081-7082	DT	denotes	a
T3883	7091-7099	NN	denotes	boundary
T3884	7083-7090	JJ	denotes	diffuse
T3885	7100-7105	IN	denotes	along
T3886	7106-7109	DT	denotes	the
T3887	7117-7122	NN	denotes	flank
T3888	7110-7116	JJ	denotes	dorsal
T3889	7122-7124	,	denotes	,
T3890	7124-7127	CC	denotes	and
T3891	7128-7129	DT	denotes	a
T3892	7147-7153	NN	denotes	region
T3893	7130-7136	JJ	denotes	dorsal
T3894	7137-7146	JJ	denotes	eumelanic
T3895	7154-7159	WP$	denotes	whose
T3896	7160-7164	NN	denotes	size
T3897	7184-7191	VBN	denotes	reduced
T3898	7165-7167	VBZ	denotes	is
T3899	7168-7183	RB	denotes	correspondingly
T3900	7192-7193	-LRB-	denotes	(
T3901	7200-7202	CD	denotes	2A
T3902	7193-7199	NN	denotes	Figure
T3903	7203-7206	CC	denotes	and
T3904	7207-7209	CD	denotes	2B
T3905	7209-7210	-RRB-	denotes	)
T3906	7210-7211	.	denotes	.
T3907	7211-7429	sentence	denotes	Total body size is smaller in mutant compared to nonmutant animals, but the proportion of body circumference occupied by the lateral region in mutant animals is increased about 2-fold, from 11.9% to 22.2% (Figure 2C).
T3908	7212-7217	JJ	denotes	Total
T3909	7223-7227	NN	denotes	size
T3910	7218-7222	NN	denotes	body
T3911	7228-7230	VBZ	denotes	is
T3912	7231-7238	JJR	denotes	smaller
T3913	7239-7241	IN	denotes	in
T3914	7242-7248	JJ	denotes	mutant
T3915	7249-7257	VBN	denotes	compared
T3916	7258-7260	IN	denotes	to
T3917	7261-7270	JJ	denotes	nonmutant
T3918	7271-7278	NNS	denotes	animals
T3919	7278-7280	,	denotes	,
T3920	7280-7283	CC	denotes	but
T3921	7284-7287	DT	denotes	the
T3922	7288-7298	NN	denotes	proportion
T3923	7373-7382	VBN	denotes	increased
T3924	7299-7301	IN	denotes	of
T3925	7302-7306	NN	denotes	body
T3926	7307-7320	NN	denotes	circumference
T3927	7321-7329	VBN	denotes	occupied
T3928	7330-7332	IN	denotes	by
T3929	7333-7336	DT	denotes	the
T3930	7345-7351	NN	denotes	region
T3931	7337-7344	JJ	denotes	lateral
T3932	7352-7354	IN	denotes	in
T3933	7355-7361	JJ	denotes	mutant
T3934	7362-7369	NNS	denotes	animals
T3935	7370-7372	VBZ	denotes	is
T3936	7383-7388	RB	denotes	about
T3937	7389-7390	CD	denotes	2
T3938	7391-7395	RB	denotes	fold
T3939	7390-7391	HYPH	denotes	-
T3940	7395-7397	,	denotes	,
T3941	7397-7401	IN	denotes	from
T3942	7402-7406	CD	denotes	11.9
T3943	7406-7407	NN	denotes	%
T3944	7408-7410	IN	denotes	to
T3945	7411-7415	CD	denotes	22.2
T3946	7415-7416	NN	denotes	%
T3947	7417-7418	-LRB-	denotes	(
T3948	7418-7424	NN	denotes	Figure
T3949	7425-7427	CD	denotes	2C
T3950	7427-7428	-RRB-	denotes	)
T3951	7428-7429	.	denotes	.
T3952	7429-7788	sentence	denotes	The proportion of the ventral cream-colored region is also expanded a small amount, 47.9% in mutant compared to 37.8% in nonmutant animals, but expansion of the lateral region, which occurs at all levels of the body, including the limbs and the cranium (but not the whisker pad), is the major feature responsible for the ventralized appearance caused by deH.
T3953	7430-7433	DT	denotes	The
T3954	7434-7444	NN	denotes	proportion
T3955	7489-7497	VBN	denotes	expanded
T3956	7445-7447	IN	denotes	of
T3957	7448-7451	DT	denotes	the
T3958	7474-7480	NN	denotes	region
T3959	7452-7459	JJ	denotes	ventral
T3960	7460-7465	NN	denotes	cream
T3961	7466-7473	VBN	denotes	colored
T3962	7465-7466	HYPH	denotes	-
T3963	7481-7483	VBZ	denotes	is
T3964	7484-7488	RB	denotes	also
T3965	7498-7499	DT	denotes	a
T3966	7506-7512	NN	denotes	amount
T3967	7500-7505	JJ	denotes	small
T3968	7512-7514	,	denotes	,
T3969	7514-7518	CD	denotes	47.9
T3970	7518-7519	NN	denotes	%
T3971	7520-7522	IN	denotes	in
T3972	7523-7529	JJ	denotes	mutant
T3973	7530-7538	VBN	denotes	compared
T3974	7539-7541	IN	denotes	to
T3975	7542-7546	CD	denotes	37.8
T3976	7546-7547	NN	denotes	%
T3977	7548-7550	IN	denotes	in
T3978	7551-7560	JJ	denotes	nonmutant
T3979	7561-7568	NNS	denotes	animals
T3980	7568-7570	,	denotes	,
T3981	7570-7573	CC	denotes	but
T3982	7574-7583	NN	denotes	expansion
T3983	7710-7712	VBZ	denotes	is
T3984	7584-7586	IN	denotes	of
T3985	7587-7590	DT	denotes	the
T3986	7599-7605	NN	denotes	region
T3987	7591-7598	JJ	denotes	lateral
T3988	7605-7607	,	denotes	,
T3989	7607-7612	WDT	denotes	which
T3990	7613-7619	VBZ	denotes	occurs
T3991	7620-7622	IN	denotes	at
T3992	7623-7626	DT	denotes	all
T3993	7627-7633	NNS	denotes	levels
T3994	7634-7636	IN	denotes	of
T3995	7637-7640	DT	denotes	the
T3996	7641-7645	NN	denotes	body
T3997	7645-7647	,	denotes	,
T3998	7647-7656	VBG	denotes	including
T3999	7657-7660	DT	denotes	the
T4000	7661-7666	NNS	denotes	limbs
T4001	7667-7670	CC	denotes	and
T4002	7671-7674	DT	denotes	the
T4003	7675-7682	NN	denotes	cranium
T4004	7683-7684	-LRB-	denotes	(
T4005	7684-7687	CC	denotes	but
T4006	7688-7691	RB	denotes	not
T4007	7692-7695	DT	denotes	the
T4008	7704-7707	NN	denotes	pad
T4009	7696-7703	NN	denotes	whisker
T4010	7707-7708	-RRB-	denotes	)
T4011	7708-7710	,	denotes	,
T4012	7713-7716	DT	denotes	the
T4013	7723-7730	NN	denotes	feature
T4014	7717-7722	JJ	denotes	major
T4015	7731-7742	JJ	denotes	responsible
T4016	7743-7746	IN	denotes	for
T4017	7747-7750	DT	denotes	the
T4018	7763-7773	NN	denotes	appearance
T4019	7751-7762	VBN	denotes	ventralized
T4020	7774-7780	VBN	denotes	caused
T4021	7781-7783	IN	denotes	by
T4022	7784-7787	NN	denotes	deH
T4023	7787-7788	.	denotes	.
T4024	7788-9253	sentence	denotes	Figure 2 The deH Pigmentation Phenotype (A) 10-wk-old deH/deH and nonmutant animals on a at background. A thin stripe of yellow hair normally separates the dorsal black hairs from the ventral cream hairs. In deH, the yellow stripe is extended dorsally, and the boundary between the yellow and the black hairs is fuzzier. (B) Skin slices taken from 1.5-mo-old deH/deH and nonmutant littermates (scale bar = 0.5 cm). (C) Proportion of total skin area as determined by observation of pelts taken from the interlimb region. The proportion occupied by the yellow lateral compartment (± SEM) differs between mutant and nonmutant littermate flanks (p < 0.0005, paired t-test, n = 6 pairs). There is also (data not shown) a small increase in the proportion of total skin area occupied by the ventral cream-colored compartment, 47.9 % in mutant compared to 37.8% in nonmutant (p < 0.005, paired t-test, n = 6 pairs). (D) On an ae/ae background, the extent of dorsal skin pigmentation is reduced in deH/deH neonates (P3.5). (E) Hair length in a representative pair of 1.5-mo-old deH/deH and nonmutant littermates, averaged over three skin slices at different rostrocaudal levels, and plotted as a function of the absolute distance from middorsum or the percentage of total slice length. To investigate whether deH affects other dorsoventral skin characteristics besides pigment-type switching, we examined its effects on hair length and pigmentation in an ae/ae background.
T4025	9067-9069	TO	denotes	To
T4026	9070-9081	VB	denotes	investigate
T4027	9177-9185	VBD	denotes	examined
T4028	9082-9089	IN	denotes	whether
T4029	9094-9101	VBZ	denotes	affects
T4030	9090-9093	NN	denotes	deH
T4031	9102-9107	JJ	denotes	other
T4032	9126-9141	NNS	denotes	characteristics
T4033	9108-9120	JJ	denotes	dorsoventral
T4034	9121-9125	NN	denotes	skin
T4035	9142-9149	IN	denotes	besides
T4036	9150-9157	NN	denotes	pigment
T4037	9158-9162	NN	denotes	type
T4038	9157-9158	HYPH	denotes	-
T4039	9163-9172	VBG	denotes	switching
T4040	9172-9174	,	denotes	,
T4041	9174-9176	PRP	denotes	we
T4042	9186-9189	PRP$	denotes	its
T4043	9190-9197	NNS	denotes	effects
T4044	9198-9200	IN	denotes	on
T4045	9201-9205	NN	denotes	hair
T4046	9206-9212	NN	denotes	length
T4047	9213-9216	CC	denotes	and
T4048	9217-9229	NN	denotes	pigmentation
T4049	9230-9232	IN	denotes	in
T4050	9233-9235	DT	denotes	an
T4051	9242-9252	NN	denotes	background
T4052	9236-9238	NN	denotes	ae
T4053	9239-9241	NN	denotes	ae
T4054	9238-9239	HYPH	denotes	/
T4055	9252-9253	.	denotes	.
T4056	9253-9494	sentence	denotes	Overall, deH causes a small but consistent reduction in hair length in both dorsum and ventrum; when mutant and nonmutant animals are normalized for body circumference, reduced hair length is most apparent in the lateral region (Figure 2E).
T4057	9254-9261	RB	denotes	Overall
T4058	9267-9273	VBZ	denotes	causes
T4059	9261-9263	,	denotes	,
T4060	9263-9266	NN	denotes	deH
T4061	9443-9445	VBZ	denotes	is
T4062	9274-9275	DT	denotes	a
T4063	9297-9306	NN	denotes	reduction
T4064	9276-9281	JJ	denotes	small
T4065	9282-9285	CC	denotes	but
T4066	9286-9296	JJ	denotes	consistent
T4067	9307-9309	IN	denotes	in
T4068	9310-9314	NN	denotes	hair
T4069	9315-9321	NN	denotes	length
T4070	9322-9324	IN	denotes	in
T4071	9325-9329	CC	denotes	both
T4072	9330-9336	NN	denotes	dorsum
T4073	9337-9340	CC	denotes	and
T4074	9341-9348	NN	denotes	ventrum
T4075	9348-9349	:	denotes	;
T4076	9350-9354	WRB	denotes	when
T4077	9388-9398	VBN	denotes	normalized
T4078	9355-9361	JJ	denotes	mutant
T4079	9376-9383	NNS	denotes	animals
T4080	9362-9365	CC	denotes	and
T4081	9366-9375	JJ	denotes	nonmutant
T4082	9384-9387	VBP	denotes	are
T4083	9399-9402	IN	denotes	for
T4084	9403-9407	NN	denotes	body
T4085	9408-9421	NN	denotes	circumference
T4086	9421-9423	,	denotes	,
T4087	9423-9430	JJ	denotes	reduced
T4088	9436-9442	NN	denotes	length
T4089	9431-9435	NN	denotes	hair
T4090	9446-9450	RBS	denotes	most
T4091	9451-9459	JJ	denotes	apparent
T4092	9460-9462	IN	denotes	in
T4093	9463-9466	DT	denotes	the
T4094	9475-9481	NN	denotes	region
T4095	9467-9474	JJ	denotes	lateral
T4096	9482-9483	-LRB-	denotes	(
T4097	9483-9489	NN	denotes	Figure
T4098	9490-9492	CD	denotes	2E
T4099	9492-9493	-RRB-	denotes	)
T4100	9493-9494	.	denotes	.
T4101	9494-9633	sentence	denotes	Adult ae/ae; deH/deH animals exhibit body-size reduction and skeletal abnormalities, but display no coat-color phenotype (data not shown).
T4102	9495-9500	JJ	denotes	Adult
T4103	9516-9523	NNS	denotes	animals
T4104	9501-9503	NN	denotes	ae
T4105	9504-9506	NN	denotes	ae
T4106	9503-9504	HYPH	denotes	/
T4107	9506-9507	,	denotes	;
T4108	9508-9511	NN	denotes	deH
T4109	9512-9515	NN	denotes	deH
T4110	9511-9512	HYPH	denotes	/
T4111	9524-9531	VBP	denotes	exhibit
T4112	9532-9536	NN	denotes	body
T4113	9537-9541	NN	denotes	size
T4114	9536-9537	HYPH	denotes	-
T4115	9542-9551	NN	denotes	reduction
T4116	9552-9555	CC	denotes	and
T4117	9556-9564	JJ	denotes	skeletal
T4118	9565-9578	NNS	denotes	abnormalities
T4119	9578-9580	,	denotes	,
T4120	9580-9583	CC	denotes	but
T4121	9584-9591	VBP	denotes	display
T4122	9592-9594	DT	denotes	no
T4123	9606-9615	NN	denotes	phenotype
T4124	9595-9599	NN	denotes	coat
T4125	9600-9605	NN	denotes	color
T4126	9599-9600	HYPH	denotes	-
T4127	9616-9617	-LRB-	denotes	(
T4128	9626-9631	VBN	denotes	shown
T4129	9617-9621	NNS	denotes	data
T4130	9622-9625	RB	denotes	not
T4131	9631-9632	-RRB-	denotes	)
T4132	9632-9633	.	denotes	.
T4133	9633-9832	sentence	denotes	However, ae/ae and ae/ae; deH/deH neonates are clearly distinguishable in the first few days after birth, when a dorsoventral gradient of melanogenic activity is apparent under the skin (Figure 2D).
T4134	9634-9641	RB	denotes	However
T4135	9677-9680	VBP	denotes	are
T4136	9641-9643	,	denotes	,
T4137	9643-9645	NN	denotes	ae
T4138	9646-9648	NN	denotes	ae
T4139	9645-9646	SYM	denotes	/
T4140	9668-9676	NNS	denotes	neonates
T4141	9649-9652	CC	denotes	and
T4142	9653-9655	NN	denotes	ae
T4143	9656-9658	NN	denotes	ae
T4144	9655-9656	SYM	denotes	/
T4145	9658-9659	,	denotes	;
T4146	9660-9663	NN	denotes	deH
T4147	9664-9667	NN	denotes	deH
T4148	9663-9664	HYPH	denotes	/
T4149	9681-9688	RB	denotes	clearly
T4150	9689-9704	JJ	denotes	distinguishable
T4151	9705-9707	IN	denotes	in
T4152	9708-9711	DT	denotes	the
T4153	9722-9726	NNS	denotes	days
T4154	9712-9717	JJ	denotes	first
T4155	9718-9721	JJ	denotes	few
T4156	9727-9732	IN	denotes	after
T4157	9733-9738	NN	denotes	birth
T4158	9738-9740	,	denotes	,
T4159	9740-9744	WRB	denotes	when
T4160	9793-9795	VBZ	denotes	is
T4161	9745-9746	DT	denotes	a
T4162	9760-9768	NN	denotes	gradient
T4163	9747-9759	JJ	denotes	dorsoventral
T4164	9769-9771	IN	denotes	of
T4165	9772-9783	JJ	denotes	melanogenic
T4166	9784-9792	NN	denotes	activity
T4167	9796-9804	JJ	denotes	apparent
T4168	9805-9810	IN	denotes	under
T4169	9811-9814	DT	denotes	the
T4170	9815-9819	NN	denotes	skin
T4171	9820-9821	-LRB-	denotes	(
T4172	9821-9827	NN	denotes	Figure
T4173	9828-9830	CD	denotes	2D
T4174	9830-9831	-RRB-	denotes	)
T4175	9831-9832	.	denotes	.
T4176	9832-10001	sentence	denotes	At this stage, melanoblast migration from the neural crest is mostly complete, but there is a dorsoventral gradient in melanocyte differentiation and pigment synthesis.
T4177	9833-9835	IN	denotes	At
T4178	9892-9894	VBZ	denotes	is
T4179	9836-9840	DT	denotes	this
T4180	9841-9846	NN	denotes	stage
T4181	9846-9848	,	denotes	,
T4182	9848-9859	NN	denotes	melanoblast
T4183	9860-9869	NN	denotes	migration
T4184	9870-9874	IN	denotes	from
T4185	9875-9878	DT	denotes	the
T4186	9886-9891	NN	denotes	crest
T4187	9879-9885	JJ	denotes	neural
T4188	9895-9901	RB	denotes	mostly
T4189	9902-9910	JJ	denotes	complete
T4190	9910-9912	,	denotes	,
T4191	9912-9915	CC	denotes	but
T4192	9916-9921	EX	denotes	there
T4193	9922-9924	VBZ	denotes	is
T4194	9925-9926	DT	denotes	a
T4195	9940-9948	NN	denotes	gradient
T4196	9927-9939	JJ	denotes	dorsoventral
T4197	9949-9951	IN	denotes	in
T4198	9952-9962	NN	denotes	melanocyte
T4199	9963-9978	NN	denotes	differentiation
T4200	9979-9982	CC	denotes	and
T4201	9983-9990	NN	denotes	pigment
T4202	9991-10000	NN	denotes	synthesis
T4203	10000-10001	.	denotes	.
T4204	10001-10258	sentence	denotes	The skin of ae/ae neonates appears uniformly dark over the entire dorsum, but in ae/ae; deH/deH neonates, the area of dark skin is more restricted, particularly above the limbs, and resembles the pattern of dorsal eumelanin in at/at; deH/deH adult animals.
T4205	10002-10005	DT	denotes	The
T4206	10006-10010	NN	denotes	skin
T4207	10029-10036	VBZ	denotes	appears
T4208	10011-10013	IN	denotes	of
T4209	10014-10016	NN	denotes	ae
T4210	10017-10019	NN	denotes	ae
T4211	10016-10017	HYPH	denotes	/
T4212	10020-10028	NNS	denotes	neonates
T4213	10037-10046	RB	denotes	uniformly
T4214	10047-10051	JJ	denotes	dark
T4215	10052-10056	IN	denotes	over
T4216	10057-10060	DT	denotes	the
T4217	10068-10074	NN	denotes	dorsum
T4218	10061-10067	JJ	denotes	entire
T4219	10074-10076	,	denotes	,
T4220	10076-10079	CC	denotes	but
T4221	10080-10082	IN	denotes	in
T4222	10130-10132	VBZ	denotes	is
T4223	10083-10085	NN	denotes	ae
T4224	10086-10088	NN	denotes	ae
T4225	10085-10086	HYPH	denotes	/
T4226	10098-10106	NNS	denotes	neonates
T4227	10088-10089	:	denotes	;
T4228	10090-10093	NN	denotes	deH
T4229	10094-10097	NN	denotes	deH
T4230	10093-10094	HYPH	denotes	/
T4231	10106-10108	,	denotes	,
T4232	10108-10111	DT	denotes	the
T4233	10112-10116	NN	denotes	area
T4234	10117-10119	IN	denotes	of
T4235	10120-10124	JJ	denotes	dark
T4236	10125-10129	NN	denotes	skin
T4237	10133-10137	RBR	denotes	more
T4238	10138-10148	JJ	denotes	restricted
T4239	10148-10150	,	denotes	,
T4240	10150-10162	RB	denotes	particularly
T4241	10163-10168	IN	denotes	above
T4242	10169-10172	DT	denotes	the
T4243	10173-10178	NNS	denotes	limbs
T4244	10178-10180	,	denotes	,
T4245	10180-10183	CC	denotes	and
T4246	10184-10193	VBZ	denotes	resembles
T4247	10194-10197	DT	denotes	the
T4248	10198-10205	NN	denotes	pattern
T4249	10206-10208	IN	denotes	of
T4250	10209-10215	JJ	denotes	dorsal
T4251	10216-10225	NN	denotes	eumelanin
T4252	10226-10228	IN	denotes	in
T4253	10229-10231	NN	denotes	at
T4254	10232-10234	NN	denotes	at
T4255	10231-10232	HYPH	denotes	/
T4256	10250-10257	NNS	denotes	animals
T4257	10234-10235	,	denotes	;
T4258	10236-10239	NN	denotes	deH
T4259	10240-10243	NN	denotes	deH
T4260	10239-10240	HYPH	denotes	/
T4261	10244-10249	JJ	denotes	adult
T4262	10257-10258	.	denotes	.
T4263	10258-10477	sentence	denotes	Taken together, these observations suggest that deH interferes with the establishment of dorsoventral patterning during skin development by causing dorsal expansion of a lateral region that is normally 3–5 mm in width.
T4264	10259-10264	VBN	denotes	Taken
T4265	10294-10301	VBP	denotes	suggest
T4266	10265-10273	RB	denotes	together
T4267	10273-10275	,	denotes	,
T4268	10275-10280	DT	denotes	these
T4269	10281-10293	NNS	denotes	observations
T4270	10302-10306	IN	denotes	that
T4271	10311-10321	VBZ	denotes	interferes
T4272	10307-10310	NN	denotes	deH
T4273	10322-10326	IN	denotes	with
T4274	10327-10330	DT	denotes	the
T4275	10331-10344	NN	denotes	establishment
T4276	10345-10347	IN	denotes	of
T4277	10348-10360	JJ	denotes	dorsoventral
T4278	10361-10371	NN	denotes	patterning
T4279	10372-10378	IN	denotes	during
T4280	10379-10383	NN	denotes	skin
T4281	10384-10395	NN	denotes	development
T4282	10396-10398	IN	denotes	by
T4283	10399-10406	VBG	denotes	causing
T4284	10407-10413	JJ	denotes	dorsal
T4285	10414-10423	NN	denotes	expansion
T4286	10424-10426	IN	denotes	of
T4287	10427-10428	DT	denotes	a
T4288	10437-10443	NN	denotes	region
T4289	10429-10436	JJ	denotes	lateral
T4290	10444-10448	WDT	denotes	that
T4291	10449-10451	VBZ	denotes	is
T4292	10452-10460	RB	denotes	normally
T4293	10461-10462	CD	denotes	3
T4294	10463-10464	CD	denotes	5
T4295	10462-10463	SYM	denotes	–
T4296	10465-10467	NN	denotes	mm
T4297	10468-10470	IN	denotes	in
T4298	10471-10476	NN	denotes	width
T4299	10476-10477	.	denotes	.
T4300	10477-10708	sentence	denotes	This same region may serve as a boundary between dorsal and ventral skin by inhibiting melanocyte differentiation, by promoting pheomelanin synthesis, and by supporting a progressive increase in hair growth from ventrum to dorsum.
T4301	10478-10482	DT	denotes	This
T4302	10488-10494	NN	denotes	region
T4303	10483-10487	JJ	denotes	same
T4304	10499-10504	VB	denotes	serve
T4305	10495-10498	MD	denotes	may
T4306	10505-10507	IN	denotes	as
T4307	10508-10509	DT	denotes	a
T4308	10510-10518	NN	denotes	boundary
T4309	10519-10526	IN	denotes	between
T4310	10527-10533	JJ	denotes	dorsal
T4311	10546-10550	NN	denotes	skin
T4312	10534-10537	CC	denotes	and
T4313	10538-10545	JJ	denotes	ventral
T4314	10551-10553	IN	denotes	by
T4315	10554-10564	VBG	denotes	inhibiting
T4316	10565-10575	NN	denotes	melanocyte
T4317	10576-10591	NN	denotes	differentiation
T4318	10591-10593	,	denotes	,
T4319	10593-10595	IN	denotes	by
T4320	10596-10605	VBG	denotes	promoting
T4321	10606-10617	NN	denotes	pheomelanin
T4322	10618-10627	NN	denotes	synthesis
T4323	10627-10629	,	denotes	,
T4324	10629-10632	CC	denotes	and
T4325	10633-10635	IN	denotes	by
T4326	10636-10646	VBG	denotes	supporting
T4327	10647-10648	DT	denotes	a
T4328	10661-10669	NN	denotes	increase
T4329	10649-10660	JJ	denotes	progressive
T4330	10670-10672	IN	denotes	in
T4331	10673-10677	NN	denotes	hair
T4332	10678-10684	NN	denotes	growth
T4333	10685-10689	IN	denotes	from
T4334	10690-10697	NN	denotes	ventrum
T4335	10698-10700	IN	denotes	to
T4336	10701-10707	NN	denotes	dorsum
T4337	10707-10708	.	denotes	.
T4338	10708-10910	sentence	denotes	As described below, the gene defective in deH, Tbx15, is normally expressed in the dorsal region and therefore is likely to play a role in establishing the size and dorsal extent of the lateral region.
T4339	10709-10711	IN	denotes	As
T4340	10712-10721	VBN	denotes	described
T4341	10775-10784	VBN	denotes	expressed
T4342	10722-10727	RB	denotes	below
T4343	10727-10729	,	denotes	,
T4344	10729-10732	DT	denotes	the
T4345	10733-10737	NN	denotes	gene
T4346	10738-10747	JJ	denotes	defective
T4347	10748-10750	IN	denotes	in
T4348	10751-10754	NN	denotes	deH
T4349	10754-10756	,	denotes	,
T4350	10756-10761	NN	denotes	Tbx15
T4351	10761-10763	,	denotes	,
T4352	10763-10765	VBZ	denotes	is
T4353	10766-10774	RB	denotes	normally
T4354	10785-10787	IN	denotes	in
T4355	10788-10791	DT	denotes	the
T4356	10799-10805	NN	denotes	region
T4357	10792-10798	JJ	denotes	dorsal
T4358	10806-10809	CC	denotes	and
T4359	10810-10819	RB	denotes	therefore
T4360	10820-10822	VBZ	denotes	is
T4361	10823-10829	JJ	denotes	likely
T4362	10830-10832	TO	denotes	to
T4363	10833-10837	VB	denotes	play
T4364	10838-10839	DT	denotes	a
T4365	10840-10844	NN	denotes	role
T4366	10845-10847	IN	denotes	in
T4367	10848-10860	VBG	denotes	establishing
T4368	10861-10864	DT	denotes	the
T4369	10865-10869	NN	denotes	size
T4370	10870-10873	CC	denotes	and
T4371	10874-10880	JJ	denotes	dorsal
T4372	10881-10887	NN	denotes	extent
T4373	10888-10890	IN	denotes	of
T4374	10891-10894	DT	denotes	the
T4375	10903-10909	NN	denotes	region
T4376	10895-10902	JJ	denotes	lateral
T4377	10909-10910	.	denotes	.
T4613	10912-10922	JJ	denotes	Positional
T4614	10923-10930	NN	denotes	Cloning
T4615	10931-10933	IN	denotes	of
T4616	10934-10937	NN	denotes	deH
T4617	10937-11223	sentence	denotes	As a visible marker, early linkage studies with the original droopy ear allele or the deH allele identified a map position in the middle of Chromosome 3, distal to matted and proximal to Varitint-waddler (Carter and Falconer 1951; Curry 1959; Lane and Eicher 1979; Holmes et al. 1981).
T4618	10938-10940	IN	denotes	As
T4619	11035-11045	VBD	denotes	identified
T4620	10941-10942	DT	denotes	a
T4621	10951-10957	NN	denotes	marker
T4622	10943-10950	JJ	denotes	visible
T4623	10957-10959	,	denotes	,
T4624	10959-10964	JJ	denotes	early
T4625	10973-10980	NNS	denotes	studies
T4626	10965-10972	NN	denotes	linkage
T4627	10981-10985	IN	denotes	with
T4628	10986-10989	DT	denotes	the
T4629	11010-11016	NN	denotes	allele
T4630	10990-10998	JJ	denotes	original
T4631	10999-11005	JJ	denotes	droopy
T4632	11006-11009	NN	denotes	ear
T4633	11017-11019	CC	denotes	or
T4634	11020-11023	DT	denotes	the
T4635	11028-11034	NN	denotes	allele
T4636	11024-11027	NN	denotes	deH
T4637	11046-11047	DT	denotes	a
T4638	11052-11060	NN	denotes	position
T4639	11048-11051	NN	denotes	map
T4640	11061-11063	IN	denotes	in
T4641	11064-11067	DT	denotes	the
T4642	11068-11074	NN	denotes	middle
T4643	11075-11077	IN	denotes	of
T4644	11078-11088	NN	denotes	Chromosome
T4645	11089-11090	CD	denotes	3
T4646	11090-11092	,	denotes	,
T4647	11092-11098	JJ	denotes	distal
T4648	11099-11101	IN	denotes	to
T4649	11102-11108	JJ	denotes	matted
T4650	11109-11112	CC	denotes	and
T4651	11113-11121	JJ	denotes	proximal
T4652	11122-11124	IN	denotes	to
T4653	11125-11133	NNP	denotes	Varitint
T4654	11134-11141	NNP	denotes	waddler
T4655	11133-11134	HYPH	denotes	-
T4656	11142-11143	-LRB-	denotes	(
T4657	11143-11149	NNP	denotes	Carter
T4658	11150-11153	CC	denotes	and
T4659	11154-11162	NNP	denotes	Falconer
T4660	11163-11167	CD	denotes	1951
T4661	11167-11168	:	denotes	;
T4662	11169-11174	NNP	denotes	Curry
T4663	11175-11179	CD	denotes	1959
T4664	11179-11180	:	denotes	;
T4665	11181-11185	NNP	denotes	Lane
T4666	11186-11189	CC	denotes	and
T4667	11190-11196	NNP	denotes	Eicher
T4668	11197-11201	CD	denotes	1979
T4669	11201-11202	:	denotes	;
T4670	11203-11209	NNP	denotes	Holmes
T4671	11210-11212	FW	denotes	et
T4672	11213-11216	FW	denotes	al.
T4673	11217-11221	CD	denotes	1981
T4674	11221-11222	-RRB-	denotes	)
T4675	11222-11223	.	denotes	.
T4676	11223-11522	sentence	denotes	We used an F2 intercross with CAST/Ei mice to localize deH to a 0.1 cM interval between D3Mit213 and 16.MMHAP32FLF1, which was refined by development of a bacterial artificial chromosome (BAC) contig and additional markers to a 1.4 Mb region that contained eight genes, including Tbx15 (Figure 3A).
T4677	11224-11226	PRP	denotes	We
T4678	11227-11231	VBD	denotes	used
T4679	11232-11234	DT	denotes	an
T4680	11238-11248	NN	denotes	intercross
T4681	11235-11237	NN	denotes	F2
T4682	11249-11253	IN	denotes	with
T4683	11254-11258	NN	denotes	CAST
T4684	11259-11261	NN	denotes	Ei
T4685	11258-11259	HYPH	denotes	/
T4686	11262-11266	NNS	denotes	mice
T4687	11267-11269	TO	denotes	to
T4688	11270-11278	VB	denotes	localize
T4689	11279-11282	NN	denotes	deH
T4690	11283-11285	IN	denotes	to
T4691	11286-11287	DT	denotes	a
T4692	11295-11303	NN	denotes	interval
T4693	11288-11291	CD	denotes	0.1
T4694	11292-11294	NN	denotes	cM
T4695	11304-11311	IN	denotes	between
T4696	11312-11320	NN	denotes	D3Mit213
T4697	11321-11324	CC	denotes	and
T4698	11325-11339	NN	denotes	16.MMHAP32FLF1
T4699	11339-11341	,	denotes	,
T4700	11341-11346	WDT	denotes	which
T4701	11351-11358	VBN	denotes	refined
T4702	11347-11350	VBD	denotes	was
T4703	11359-11361	IN	denotes	by
T4704	11362-11373	NN	denotes	development
T4705	11374-11376	IN	denotes	of
T4706	11377-11378	DT	denotes	a
T4707	11417-11423	NN	denotes	contig
T4708	11379-11388	JJ	denotes	bacterial
T4709	11400-11410	NN	denotes	chromosome
T4710	11389-11399	JJ	denotes	artificial
T4711	11411-11412	-LRB-	denotes	(
T4712	11412-11415	NN	denotes	BAC
T4713	11415-11416	-RRB-	denotes	)
T4714	11424-11427	CC	denotes	and
T4715	11428-11438	JJ	denotes	additional
T4716	11439-11446	NNS	denotes	markers
T4717	11447-11449	IN	denotes	to
T4718	11450-11451	DT	denotes	a
T4719	11459-11465	NN	denotes	region
T4720	11452-11455	CD	denotes	1.4
T4721	11456-11458	NN	denotes	Mb
T4722	11466-11470	WDT	denotes	that
T4723	11471-11480	VBD	denotes	contained
T4724	11481-11486	CD	denotes	eight
T4725	11487-11492	NNS	denotes	genes
T4726	11492-11494	,	denotes	,
T4727	11494-11503	VBG	denotes	including
T4728	11504-11509	NN	denotes	Tbx15
T4729	11510-11511	-LRB-	denotes	(
T4730	11511-11517	NN	denotes	Figure
T4731	11518-11520	CD	denotes	3A
T4732	11520-11521	-RRB-	denotes	)
T4733	11521-11522	.	denotes	.
T4734	11522-11745	sentence	denotes	We considered Tbx15 as an excellent candidate for the skeletal abnormalities caused by deH, based on studies by Agulnik et al. (1998), who described its embryonic expression in the craniofacial region and developing limbs.
T4735	11523-11525	PRP	denotes	We
T4736	11526-11536	VBD	denotes	considered
T4737	11537-11542	NN	denotes	Tbx15
T4738	11543-11545	IN	denotes	as
T4739	11546-11548	DT	denotes	an
T4740	11559-11568	NN	denotes	candidate
T4741	11549-11558	JJ	denotes	excellent
T4742	11569-11572	IN	denotes	for
T4743	11573-11576	DT	denotes	the
T4744	11586-11599	NNS	denotes	abnormalities
T4745	11577-11585	JJ	denotes	skeletal
T4746	11600-11606	VBN	denotes	caused
T4747	11607-11609	IN	denotes	by
T4748	11610-11613	NN	denotes	deH
T4749	11613-11615	,	denotes	,
T4750	11615-11620	VBN	denotes	based
T4751	11621-11623	IN	denotes	on
T4752	11624-11631	NNS	denotes	studies
T4753	11632-11634	IN	denotes	by
T4754	11635-11642	NNP	denotes	Agulnik
T4755	11643-11645	FW	denotes	et
T4756	11646-11649	FW	denotes	al.
T4757	11650-11651	-LRB-	denotes	(
T4758	11651-11655	CD	denotes	1998
T4759	11655-11656	-RRB-	denotes	)
T4760	11656-11658	,	denotes	,
T4761	11658-11661	WP	denotes	who
T4762	11662-11671	VBD	denotes	described
T4763	11672-11675	PRP$	denotes	its
T4764	11686-11696	NN	denotes	expression
T4765	11676-11685	JJ	denotes	embryonic
T4766	11697-11699	IN	denotes	in
T4767	11700-11703	DT	denotes	the
T4768	11717-11723	NN	denotes	region
T4769	11704-11716	JJ	denotes	craniofacial
T4770	11724-11727	CC	denotes	and
T4771	11728-11738	VBG	denotes	developing
T4772	11739-11744	NNS	denotes	limbs
T4773	11744-11745	.	denotes	.
T4774	11745-12880	sentence	denotes	Figure 3 Molecular Genetics of deH and Tbx15 (A) Genetic and physical map, as described in the text. Markers M1 to M3 are SSCP markers generated from a BAC contig of the region; marker M4 is STS 16.MMHAP32FLF1 and was also used as an SSCP marker. M2 and M3, which flank the Tbx15 and M6pr-ps on the UCSC genome browser map and lie 634 kb apart, were nonrecombinant with deH in 2340 meioses. (B) The deH mutation is a deletion that starts in Tbx15 intron 1 and ends in the M6pr-ps. (C) Sequence of deletion breakpoints. (D) Diagram of Tbx15LacZ allele constructed by gene targeting. As described in the text, this allele is predicted to give rise to a protein truncated after approximately 154 codons and is lacking critical residues of the T box. Heterozygotes for the targeted allele exhibit normal size, morphology, and hair-color patterns, but homozygotes and Tbx15LacZ/deH compound heterozygotes are identical to deH homozygotes. Using sequence information from Agulnik et al. (1998) and the partially completed mouse genome sequence, we found that portions of several Tbx15 exons could not be amplified from deH/deH genomic DNA.
T4775	12681-12686	VBG	denotes	Using
T4776	12789-12794	VBD	denotes	found
T4777	12687-12695	NN	denotes	sequence
T4778	12696-12707	NN	denotes	information
T4779	12708-12712	IN	denotes	from
T4780	12713-12720	NNP	denotes	Agulnik
T4781	12721-12723	FW	denotes	et
T4782	12724-12727	FW	denotes	al.
T4783	12728-12729	-LRB-	denotes	(
T4784	12729-12733	CD	denotes	1998
T4785	12733-12734	-RRB-	denotes	)
T4786	12735-12738	CC	denotes	and
T4787	12739-12742	DT	denotes	the
T4788	12776-12784	NN	denotes	sequence
T4789	12743-12752	RB	denotes	partially
T4790	12753-12762	VBN	denotes	completed
T4791	12763-12768	NN	denotes	mouse
T4792	12769-12775	NN	denotes	genome
T4793	12784-12786	,	denotes	,
T4794	12786-12788	PRP	denotes	we
T4795	12795-12799	IN	denotes	that
T4796	12845-12854	VBN	denotes	amplified
T4797	12800-12808	NNS	denotes	portions
T4798	12809-12811	IN	denotes	of
T4799	12812-12819	JJ	denotes	several
T4800	12826-12831	NNS	denotes	exons
T4801	12820-12825	NN	denotes	Tbx15
T4802	12832-12837	MD	denotes	could
T4803	12838-12841	RB	denotes	not
T4804	12842-12844	VB	denotes	be
T4805	12855-12859	IN	denotes	from
T4806	12860-12863	NN	denotes	deH
T4807	12864-12867	NN	denotes	deH
T4808	12863-12864	HYPH	denotes	/
T4809	12876-12879	NN	denotes	DNA
T4810	12868-12875	JJ	denotes	genomic
T4811	12879-12880	.	denotes	.
T4812	12880-13093	sentence	denotes	The same gene was initially referred to as Tbx8 (Wattler et al. 1998) and then later renamed Tbx14, but is currently referred to in several vertebrate genomes as Tbx15 (Agulnik et al. 1998; Begemann et al. 2002).
T4813	12881-12884	DT	denotes	The
T4814	12890-12894	NN	denotes	gene
T4815	12885-12889	JJ	denotes	same
T4816	12909-12917	VBN	denotes	referred
T4817	12895-12898	VBD	denotes	was
T4818	12899-12908	RB	denotes	initially
T4819	12918-12920	IN	denotes	to
T4820	12921-12923	IN	denotes	as
T4821	12924-12928	NN	denotes	Tbx8
T4822	12929-12930	-LRB-	denotes	(
T4823	12930-12937	NNP	denotes	Wattler
T4824	12938-12940	FW	denotes	et
T4825	12941-12944	FW	denotes	al.
T4826	12945-12949	CD	denotes	1998
T4827	12949-12950	-RRB-	denotes	)
T4828	12951-12954	CC	denotes	and
T4829	12955-12959	RB	denotes	then
T4830	12966-12973	VBN	denotes	renamed
T4831	12960-12965	RB	denotes	later
T4832	12974-12979	NN	denotes	Tbx14
T4833	12979-12981	,	denotes	,
T4834	12981-12984	CC	denotes	but
T4835	12985-12987	VBZ	denotes	is
T4836	12998-13006	VBN	denotes	referred
T4837	12988-12997	RB	denotes	currently
T4838	13007-13009	IN	denotes	to
T4839	13010-13012	IN	denotes	in
T4840	13013-13020	JJ	denotes	several
T4841	13032-13039	NNS	denotes	genomes
T4842	13021-13031	NN	denotes	vertebrate
T4843	13040-13042	IN	denotes	as
T4844	13043-13048	NN	denotes	Tbx15
T4845	13049-13050	-LRB-	denotes	(
T4846	13050-13057	NNP	denotes	Agulnik
T4847	13058-13060	FW	denotes	et
T4848	13061-13064	FW	denotes	al.
T4849	13065-13069	CD	denotes	1998
T4850	13069-13070	:	denotes	;
T4851	13071-13079	NNP	denotes	Begemann
T4852	13080-13082	FW	denotes	et
T4853	13083-13086	FW	denotes	al.
T4854	13087-13091	CD	denotes	2002
T4855	13091-13092	-RRB-	denotes	)
T4856	13092-13093	.	denotes	.
T4857	13093-13443	sentence	denotes	By comparing the sequence of a 1.3 kb junction fragment amplified from deH/deH genomic DNA to publicly available mouse genome sequence, we identified a 216 kb deletion that extends from Tbx15 intron 1 to 148 kb downstream of the polyadenylation sequence in a region annotated as a mannose-6-phosphate receptor pseudogene, M6pr-ps (Figure 3B and 3C).
T4858	13094-13096	IN	denotes	By
T4859	13233-13243	VBD	denotes	identified
T4860	13097-13106	VBG	denotes	comparing
T4861	13107-13110	DT	denotes	the
T4862	13111-13119	NN	denotes	sequence
T4863	13120-13122	IN	denotes	of
T4864	13123-13124	DT	denotes	a
T4865	13141-13149	NN	denotes	fragment
T4866	13125-13128	CD	denotes	1.3
T4867	13129-13131	NN	denotes	kb
T4868	13132-13140	NN	denotes	junction
T4869	13150-13159	VBN	denotes	amplified
T4870	13160-13164	IN	denotes	from
T4871	13165-13168	NN	denotes	deH
T4872	13169-13172	NN	denotes	deH
T4873	13168-13169	HYPH	denotes	/
T4874	13181-13184	NN	denotes	DNA
T4875	13173-13180	JJ	denotes	genomic
T4876	13185-13187	IN	denotes	to
T4877	13188-13196	RB	denotes	publicly
T4878	13197-13206	JJ	denotes	available
T4879	13220-13228	NN	denotes	sequence
T4880	13207-13212	NN	denotes	mouse
T4881	13213-13219	NN	denotes	genome
T4882	13228-13230	,	denotes	,
T4883	13230-13232	PRP	denotes	we
T4884	13244-13245	DT	denotes	a
T4885	13253-13261	NN	denotes	deletion
T4886	13246-13249	CD	denotes	216
T4887	13250-13252	NN	denotes	kb
T4888	13262-13266	WDT	denotes	that
T4889	13267-13274	VBZ	denotes	extends
T4890	13275-13279	IN	denotes	from
T4891	13280-13285	NN	denotes	Tbx15
T4892	13286-13292	NN	denotes	intron
T4893	13293-13294	CD	denotes	1
T4894	13295-13297	IN	denotes	to
T4895	13298-13301	CD	denotes	148
T4896	13302-13304	NN	denotes	kb
T4897	13305-13315	RB	denotes	downstream
T4898	13316-13318	IN	denotes	of
T4899	13319-13322	DT	denotes	the
T4900	13339-13347	NN	denotes	sequence
T4901	13323-13338	NN	denotes	polyadenylation
T4902	13348-13350	IN	denotes	in
T4903	13351-13352	DT	denotes	a
T4904	13353-13359	NN	denotes	region
T4905	13360-13369	VBN	denotes	annotated
T4906	13370-13372	IN	denotes	as
T4907	13373-13374	DT	denotes	a
T4908	13404-13414	NN	denotes	pseudogene
T4909	13375-13382	NN	denotes	mannose
T4910	13385-13394	NN	denotes	phosphate
T4911	13382-13383	HYPH	denotes	-
T4912	13383-13384	CD	denotes	6
T4913	13384-13385	HYPH	denotes	-
T4914	13395-13403	NN	denotes	receptor
T4915	13414-13416	,	denotes	,
T4916	13416-13420	NN	denotes	M6pr
T4917	13421-13423	NN	denotes	ps
T4918	13420-13421	HYPH	denotes	-
T4919	13424-13425	-LRB-	denotes	(
T4920	13432-13434	CD	denotes	3B
T4921	13425-13431	NN	denotes	Figure
T4922	13435-13438	CC	denotes	and
T4923	13439-13441	CD	denotes	3C
T4924	13441-13442	-RRB-	denotes	)
T4925	13442-13443	.	denotes	.
T4926	13443-13465	sentence	denotes	(Ludwig et al. 1992).
T4927	13444-13445	-LRB-	denotes	(
T4928	13445-13451	NNP	denotes	Ludwig
T4929	13452-13454	FW	denotes	et
T4930	13455-13458	FW	denotes	al.
T4931	13459-13463	CD	denotes	1992
T4932	13463-13464	-RRB-	denotes	)
T4933	13464-13465	.	denotes	.
T4934	13465-13577	sentence	denotes	By Northern blot analysis, we identified a fusion transcript produced from the deH chromosome (data not shown).
T4935	13466-13468	IN	denotes	By
T4936	13496-13506	VBD	denotes	identified
T4937	13469-13477	NNP	denotes	Northern
T4938	13478-13482	NN	denotes	blot
T4939	13483-13491	NN	denotes	analysis
T4940	13491-13493	,	denotes	,
T4941	13493-13495	PRP	denotes	we
T4942	13507-13508	DT	denotes	a
T4943	13516-13526	NN	denotes	transcript
T4944	13509-13515	NN	denotes	fusion
T4945	13527-13535	VBN	denotes	produced
T4946	13536-13540	IN	denotes	from
T4947	13541-13544	DT	denotes	the
T4948	13549-13559	NN	denotes	chromosome
T4949	13545-13548	NN	denotes	deH
T4950	13560-13561	-LRB-	denotes	(
T4951	13570-13575	VBN	denotes	shown
T4952	13561-13565	NNS	denotes	data
T4953	13566-13569	RB	denotes	not
T4954	13575-13576	-RRB-	denotes	)
T4955	13576-13577	.	denotes	.
T4956	13577-13820	sentence	denotes	However, the deletion removes 534 of the 602 amino acids encoded by Tbx15 (including the T-box DNA-binding domain), deH/+ animals are grossly normal, and the phenotype of deH/deH animals is identical to that described for the original allele.
T4957	13578-13585	RB	denotes	However
T4958	13600-13607	VBZ	denotes	removes
T4959	13585-13587	,	denotes	,
T4960	13587-13590	DT	denotes	the
T4961	13591-13599	NN	denotes	deletion
T4962	13608-13611	CD	denotes	534
T4963	13619-13622	CD	denotes	602
T4964	13612-13614	IN	denotes	of
T4965	13615-13618	DT	denotes	the
T4966	13629-13634	NNS	denotes	acids
T4967	13623-13628	NN	denotes	amino
T4968	13635-13642	VBN	denotes	encoded
T4969	13643-13645	IN	denotes	by
T4970	13646-13651	NN	denotes	Tbx15
T4971	13652-13653	-LRB-	denotes	(
T4972	13653-13662	VBG	denotes	including
T4973	13663-13666	DT	denotes	the
T4974	13685-13691	NN	denotes	domain
T4975	13667-13668	NN	denotes	T
T4976	13669-13672	NN	denotes	box
T4977	13668-13669	HYPH	denotes	-
T4978	13673-13676	NN	denotes	DNA
T4979	13677-13684	VBG	denotes	binding
T4980	13676-13677	HYPH	denotes	-
T4981	13691-13692	-RRB-	denotes	)
T4982	13692-13694	,	denotes	,
T4983	13694-13697	NN	denotes	deH
T4984	13700-13707	NNS	denotes	animals
T4985	13697-13698	HYPH	denotes	/
T4986	13698-13699	SYM	denotes	+
T4987	13708-13711	VBP	denotes	are
T4988	13712-13719	RB	denotes	grossly
T4989	13720-13726	JJ	denotes	normal
T4990	13726-13728	,	denotes	,
T4991	13728-13731	CC	denotes	and
T4992	13732-13735	DT	denotes	the
T4993	13736-13745	NN	denotes	phenotype
T4994	13765-13767	VBZ	denotes	is
T4995	13746-13748	IN	denotes	of
T4996	13749-13752	NN	denotes	deH
T4997	13753-13756	NN	denotes	deH
T4998	13752-13753	HYPH	denotes	/
T4999	13757-13764	NNS	denotes	animals
T5000	13768-13777	JJ	denotes	identical
T5001	13778-13780	IN	denotes	to
T5002	13781-13785	DT	denotes	that
T5003	13786-13795	VBN	denotes	described
T5004	13796-13799	IN	denotes	for
T5005	13800-13803	DT	denotes	the
T5006	13813-13819	NN	denotes	allele
T5007	13804-13812	JJ	denotes	original
T5008	13819-13820	.	denotes	.
T5009	13820-13927	sentence	denotes	In addition, other than M6pr-ps, no other genes or transcripts have been annotated to the 216 kb deletion.
T5010	13821-13823	IN	denotes	In
T5011	13894-13903	VBN	denotes	annotated
T5012	13824-13832	NN	denotes	addition
T5013	13832-13834	,	denotes	,
T5014	13834-13839	JJ	denotes	other
T5015	13840-13844	IN	denotes	than
T5016	13845-13849	NN	denotes	M6pr
T5017	13850-13852	NN	denotes	ps
T5018	13849-13850	HYPH	denotes	-
T5019	13852-13854	,	denotes	,
T5020	13854-13856	DT	denotes	no
T5021	13863-13868	NNS	denotes	genes
T5022	13857-13862	JJ	denotes	other
T5023	13869-13871	CC	denotes	or
T5024	13872-13883	NNS	denotes	transcripts
T5025	13884-13888	VBP	denotes	have
T5026	13889-13893	VBN	denotes	been
T5027	13904-13906	IN	denotes	to
T5028	13907-13910	DT	denotes	the
T5029	13918-13926	NN	denotes	deletion
T5030	13911-13914	CD	denotes	216
T5031	13915-13917	NN	denotes	kb
T5032	13926-13927	.	denotes	.
T5033	13927-14081	sentence	denotes	While the positional cloning work was underway, one of us (A. Russ) generated an independent mutation of Tbx15 by gene targeting in embryonic stem cells.
T5034	13928-13933	IN	denotes	While
T5035	13962-13965	VBD	denotes	was
T5036	13934-13937	DT	denotes	the
T5037	13957-13961	NN	denotes	work
T5038	13938-13948	JJ	denotes	positional
T5039	13949-13956	NN	denotes	cloning
T5040	13996-14005	VBD	denotes	generated
T5041	13966-13974	RB	denotes	underway
T5042	13974-13976	,	denotes	,
T5043	13976-13979	CD	denotes	one
T5044	13980-13982	IN	denotes	of
T5045	13983-13985	PRP	denotes	us
T5046	13986-13987	-LRB-	denotes	(
T5047	13987-13989	NNP	denotes	A.
T5048	13990-13994	NNP	denotes	Russ
T5049	13994-13995	-RRB-	denotes	)
T5050	14006-14008	DT	denotes	an
T5051	14021-14029	NN	denotes	mutation
T5052	14009-14020	JJ	denotes	independent
T5053	14030-14032	IN	denotes	of
T5054	14033-14038	NN	denotes	Tbx15
T5055	14039-14041	IN	denotes	by
T5056	14042-14046	NN	denotes	gene
T5057	14047-14056	NN	denotes	targeting
T5058	14057-14059	IN	denotes	in
T5059	14060-14069	JJ	denotes	embryonic
T5060	14075-14080	NNS	denotes	cells
T5061	14070-14074	NN	denotes	stem
T5062	14080-14081	.	denotes	.
T5063	14081-14241	sentence	denotes	The targeted allele, Tbx15LacZ, carries an IRES-LacZ-neo cDNA cassette that disrupts the open reading frame at codon 154 early in the T-box domain (Figure 3D).
T5064	14082-14085	DT	denotes	The
T5065	14095-14101	NN	denotes	allele
T5066	14086-14094	VBN	denotes	targeted
T5067	14114-14121	VBZ	denotes	carries
T5068	14101-14103	,	denotes	,
T5069	14103-14112	NN	denotes	Tbx15LacZ
T5070	14112-14114	,	denotes	,
T5071	14122-14124	DT	denotes	an
T5072	14144-14152	NN	denotes	cassette
T5073	14125-14129	NN	denotes	IRES
T5074	14130-14134	NN	denotes	LacZ
T5075	14129-14130	HYPH	denotes	-
T5076	14134-14135	HYPH	denotes	-
T5077	14135-14138	JJ	denotes	neo
T5078	14139-14143	NN	denotes	cDNA
T5079	14153-14157	WDT	denotes	that
T5080	14158-14166	VBZ	denotes	disrupts
T5081	14167-14170	DT	denotes	the
T5082	14184-14189	NN	denotes	frame
T5083	14171-14175	JJ	denotes	open
T5084	14176-14183	NN	denotes	reading
T5085	14190-14192	IN	denotes	at
T5086	14193-14198	NN	denotes	codon
T5087	14199-14202	CD	denotes	154
T5088	14203-14208	RB	denotes	early
T5089	14209-14211	IN	denotes	in
T5090	14212-14215	DT	denotes	the
T5091	14222-14228	NN	denotes	domain
T5092	14216-14217	NN	denotes	T
T5093	14218-14221	NN	denotes	box
T5094	14217-14218	HYPH	denotes	-
T5095	14229-14230	-LRB-	denotes	(
T5096	14230-14236	NN	denotes	Figure
T5097	14237-14239	CD	denotes	3D
T5098	14239-14240	-RRB-	denotes	)
T5099	14240-14241	.	denotes	.
T5100	14241-14528	sentence	denotes	Animals heterozygous for the targeted allele are completely normal with regard to size, skeletal morphology, and hair-color distribution, but Tbx15LacZ/Tbx15LacZ homozygotes were noted to exhibit reduced body size and an abnormal craniofacial appearance identical to that caused by deH.
T5101	14242-14249	NNS	denotes	Animals
T5102	14287-14290	VBP	denotes	are
T5103	14250-14262	JJ	denotes	heterozygous
T5104	14263-14266	IN	denotes	for
T5105	14267-14270	DT	denotes	the
T5106	14280-14286	NN	denotes	allele
T5107	14271-14279	VBN	denotes	targeted
T5108	14291-14301	RB	denotes	completely
T5109	14302-14308	JJ	denotes	normal
T5110	14309-14313	IN	denotes	with
T5111	14314-14320	NN	denotes	regard
T5112	14321-14323	IN	denotes	to
T5113	14324-14328	NN	denotes	size
T5114	14328-14330	,	denotes	,
T5115	14330-14338	JJ	denotes	skeletal
T5116	14339-14349	NN	denotes	morphology
T5117	14349-14351	,	denotes	,
T5118	14351-14354	CC	denotes	and
T5119	14355-14359	NN	denotes	hair
T5120	14360-14365	NN	denotes	color
T5121	14359-14360	HYPH	denotes	-
T5122	14366-14378	NN	denotes	distribution
T5123	14378-14380	,	denotes	,
T5124	14380-14383	CC	denotes	but
T5125	14384-14393	NN	denotes	Tbx15LacZ
T5126	14394-14403	NN	denotes	Tbx15LacZ
T5127	14393-14394	HYPH	denotes	/
T5128	14404-14415	NNS	denotes	homozygotes
T5129	14421-14426	VBN	denotes	noted
T5130	14416-14420	VBD	denotes	were
T5131	14427-14429	TO	denotes	to
T5132	14430-14437	VB	denotes	exhibit
T5133	14438-14445	VBN	denotes	reduced
T5134	14451-14455	NN	denotes	size
T5135	14446-14450	NN	denotes	body
T5136	14456-14459	CC	denotes	and
T5137	14460-14462	DT	denotes	an
T5138	14485-14495	NN	denotes	appearance
T5139	14463-14471	JJ	denotes	abnormal
T5140	14472-14484	JJ	denotes	craniofacial
T5141	14496-14505	JJ	denotes	identical
T5142	14506-14508	IN	denotes	to
T5143	14509-14513	DT	denotes	that
T5144	14514-14520	VBN	denotes	caused
T5145	14521-14523	IN	denotes	by
T5146	14524-14527	NN	denotes	deH
T5147	14527-14528	.	denotes	.
T5148	14528-14774	sentence	denotes	We generated Tbx15LacZ/deH compound heterozygotes; on an Aw/at background, these animals exhibited the same abnormal restriction of dorsal pigmentation at P3.5 and expanded yellow flank area as described above for deH/deH animals (see Figure 2).
T5149	14529-14531	PRP	denotes	We
T5150	14532-14541	VBD	denotes	generated
T5151	14618-14627	VBD	denotes	exhibited
T5152	14542-14551	NN	denotes	Tbx15LacZ
T5153	14552-14555	NN	denotes	deH
T5154	14551-14552	SYM	denotes	/
T5155	14565-14578	NNS	denotes	heterozygotes
T5156	14556-14564	NN	denotes	compound
T5157	14578-14579	:	denotes	;
T5158	14580-14582	IN	denotes	on
T5159	14583-14585	DT	denotes	an
T5160	14592-14602	NN	denotes	background
T5161	14586-14588	NN	denotes	Aw
T5162	14589-14591	NN	denotes	at
T5163	14588-14589	HYPH	denotes	/
T5164	14602-14604	,	denotes	,
T5165	14604-14609	DT	denotes	these
T5166	14610-14617	NNS	denotes	animals
T5167	14628-14631	DT	denotes	the
T5168	14646-14657	NN	denotes	restriction
T5169	14632-14636	JJ	denotes	same
T5170	14637-14645	JJ	denotes	abnormal
T5171	14658-14660	IN	denotes	of
T5172	14661-14667	JJ	denotes	dorsal
T5173	14668-14680	NN	denotes	pigmentation
T5174	14681-14683	IN	denotes	at
T5175	14684-14688	NN	denotes	P3.5
T5176	14689-14692	CC	denotes	and
T5177	14693-14701	VBN	denotes	expanded
T5178	14715-14719	NN	denotes	area
T5179	14702-14708	JJ	denotes	yellow
T5180	14709-14714	NN	denotes	flank
T5181	14720-14722	IN	denotes	as
T5182	14723-14732	VBN	denotes	described
T5183	14733-14738	RB	denotes	above
T5184	14739-14742	IN	denotes	for
T5185	14743-14746	NN	denotes	deH
T5186	14747-14750	NN	denotes	deH
T5187	14746-14747	HYPH	denotes	/
T5188	14751-14758	NNS	denotes	animals
T5189	14759-14760	-LRB-	denotes	(
T5190	14760-14763	VB	denotes	see
T5191	14764-14770	NN	denotes	Figure
T5192	14771-14772	CD	denotes	2
T5193	14772-14773	-RRB-	denotes	)
T5194	14773-14774	.	denotes	.
T5195	14774-14907	sentence	denotes	These observations demonstrate that the pigmentary and craniofacial characteristics of deH are caused by loss of function for Tbx15.
T5196	14775-14780	DT	denotes	These
T5197	14781-14793	NNS	denotes	observations
T5198	14794-14805	VBP	denotes	demonstrate
T5199	14806-14810	IN	denotes	that
T5200	14870-14876	VBN	denotes	caused
T5201	14811-14814	DT	denotes	the
T5202	14843-14858	NNS	denotes	characteristics
T5203	14815-14825	JJ	denotes	pigmentary
T5204	14826-14829	CC	denotes	and
T5205	14830-14842	JJ	denotes	craniofacial
T5206	14859-14861	IN	denotes	of
T5207	14862-14865	NN	denotes	deH
T5208	14866-14869	VBP	denotes	are
T5209	14877-14879	IN	denotes	by
T5210	14880-14884	NN	denotes	loss
T5211	14885-14887	IN	denotes	of
T5212	14888-14896	NN	denotes	function
T5213	14897-14900	IN	denotes	for
T5214	14901-14906	NN	denotes	Tbx15
T5215	14906-14907	.	denotes	.
T5465	14909-14919	NN	denotes	Expression
T5466	14920-14922	IN	denotes	of
T5467	14923-14928	NN	denotes	Tbx15
T5468	14929-14932	CC	denotes	and
T5469	14933-14939	NN	denotes	Agouti
T5470	14939-15182	sentence	denotes	Previous studies by Agulnik et al. (1998) using whole-mount in situ hybridization described expression of Tbx15 as first detectable at E9.5 in the limb buds, progressing to the branchial arches, flanks, and craniofacial regions through E12.5.
T5471	14940-14948	JJ	denotes	Previous
T5472	14949-14956	NNS	denotes	studies
T5473	15022-15031	VBD	denotes	described
T5474	14957-14959	IN	denotes	by
T5475	14960-14967	NNP	denotes	Agulnik
T5476	14968-14970	FW	denotes	et
T5477	14971-14974	FW	denotes	al.
T5478	14975-14976	-LRB-	denotes	(
T5479	14976-14980	CD	denotes	1998
T5480	14980-14981	-RRB-	denotes	)
T5481	14982-14987	VBG	denotes	using
T5482	14988-14993	JJ	denotes	whole
T5483	14994-14999	NN	denotes	mount
T5484	14993-14994	HYPH	denotes	-
T5485	15008-15021	NN	denotes	hybridization
T5486	15000-15002	FW	denotes	in
T5487	15003-15007	FW	denotes	situ
T5488	15032-15042	NN	denotes	expression
T5489	15043-15045	IN	denotes	of
T5490	15046-15051	NN	denotes	Tbx15
T5491	15052-15054	IN	denotes	as
T5492	15055-15060	RB	denotes	first
T5493	15061-15071	JJ	denotes	detectable
T5494	15072-15074	IN	denotes	at
T5495	15075-15079	NN	denotes	E9.5
T5496	15080-15082	IN	denotes	in
T5497	15083-15086	DT	denotes	the
T5498	15092-15096	NNS	denotes	buds
T5499	15087-15091	NN	denotes	limb
T5500	15096-15098	,	denotes	,
T5501	15098-15109	VBG	denotes	progressing
T5502	15110-15112	IN	denotes	to
T5503	15113-15116	DT	denotes	the
T5504	15127-15133	NNS	denotes	arches
T5505	15117-15126	JJ	denotes	branchial
T5506	15133-15135	,	denotes	,
T5507	15135-15141	NNS	denotes	flanks
T5508	15141-15143	,	denotes	,
T5509	15143-15146	CC	denotes	and
T5510	15147-15159	JJ	denotes	craniofacial
T5511	15160-15167	NNS	denotes	regions
T5512	15168-15175	IN	denotes	through
T5513	15176-15181	NN	denotes	E12.5
T5514	15181-15182	.	denotes	.
T5515	15182-15559	sentence	denotes	To investigate this pattern in more detail, we hybridized a Tbx15 mRNA probe to a series of transverse sections at E12.5 and observed expression in multiple mesenchymal tissues of the head, trunk, and developing limbs (Figure 4A), much of which is consistent with the skull, cervical vertebrae, and limb malformations reported for mice carrying the original droopy ear allele.
T5516	15183-15185	TO	denotes	To
T5517	15186-15197	VB	denotes	investigate
T5518	15230-15240	VBD	denotes	hybridized
T5519	15198-15202	DT	denotes	this
T5520	15203-15210	NN	denotes	pattern
T5521	15211-15213	IN	denotes	in
T5522	15214-15218	JJR	denotes	more
T5523	15219-15225	NN	denotes	detail
T5524	15225-15227	,	denotes	,
T5525	15227-15229	PRP	denotes	we
T5526	15241-15242	DT	denotes	a
T5527	15254-15259	NN	denotes	probe
T5528	15243-15248	NN	denotes	Tbx15
T5529	15249-15253	NN	denotes	mRNA
T5530	15260-15262	IN	denotes	to
T5531	15263-15264	DT	denotes	a
T5532	15265-15271	NN	denotes	series
T5533	15272-15274	IN	denotes	of
T5534	15275-15285	JJ	denotes	transverse
T5535	15286-15294	NNS	denotes	sections
T5536	15295-15297	IN	denotes	at
T5537	15298-15303	NN	denotes	E12.5
T5538	15304-15307	CC	denotes	and
T5539	15308-15316	VBD	denotes	observed
T5540	15317-15327	NN	denotes	expression
T5541	15328-15330	IN	denotes	in
T5542	15331-15339	JJ	denotes	multiple
T5543	15352-15359	NNS	denotes	tissues
T5544	15340-15351	JJ	denotes	mesenchymal
T5545	15360-15362	IN	denotes	of
T5546	15363-15366	DT	denotes	the
T5547	15367-15371	NN	denotes	head
T5548	15371-15373	,	denotes	,
T5549	15373-15378	NN	denotes	trunk
T5550	15378-15380	,	denotes	,
T5551	15380-15383	CC	denotes	and
T5552	15384-15394	VBG	denotes	developing
T5553	15395-15400	NNS	denotes	limbs
T5554	15401-15402	-LRB-	denotes	(
T5555	15402-15408	NN	denotes	Figure
T5556	15409-15411	CD	denotes	4A
T5557	15411-15412	-RRB-	denotes	)
T5558	15412-15414	,	denotes	,
T5559	15414-15418	JJ	denotes	much
T5560	15428-15430	VBZ	denotes	is
T5561	15419-15421	IN	denotes	of
T5562	15422-15427	WDT	denotes	which
T5563	15431-15441	JJ	denotes	consistent
T5564	15442-15446	IN	denotes	with
T5565	15447-15450	DT	denotes	the
T5566	15487-15500	NNS	denotes	malformations
T5567	15451-15456	NN	denotes	skull
T5568	15456-15458	,	denotes	,
T5569	15458-15466	JJ	denotes	cervical
T5570	15467-15476	NNS	denotes	vertebrae
T5571	15476-15478	,	denotes	,
T5572	15478-15481	CC	denotes	and
T5573	15482-15486	NN	denotes	limb
T5574	15501-15509	VBN	denotes	reported
T5575	15510-15513	IN	denotes	for
T5576	15514-15518	NNS	denotes	mice
T5577	15519-15527	VBG	denotes	carrying
T5578	15528-15531	DT	denotes	the
T5579	15552-15558	NN	denotes	allele
T5580	15532-15540	JJ	denotes	original
T5581	15541-15547	JJ	denotes	droopy
T5582	15548-15551	NN	denotes	ear
T5583	15558-15559	.	denotes	.
T5584	15559-16510	sentence	denotes	Figure 4 Developmental Expression of Tbx15 (A) At E12.5, transverse sections at different levels show expression in head mesenchyme (a and b); myotome, occipital, and periocular mesenchyme (b); palatal shelf, cervical sclerotome, and nasal cartilage (c); maxillary and mandibular processes (d); limbs (e); and myotome and lateral mesenchyme (e and f) (scale bars = 500 μm). (B) Transverse sections through the flank at different times show expression in lateral mesenchyme (E11.5), expanding dorsally at E12.5, and both ventrally and dorsally at E13.5, detectable in loose mesenchyme underlying the dermis and the abdominal and subcutaneous muscles (scale bar = 500 μm). At P3.5, Tbx15 is expressed in the entire dermis and is most strongly expressed in dermal sheaths (scale bar = 200 μm). We were particularly interested in determining the exact nature of the embryonic flank expression relative to the ventralized phenotype of adult deH/deH mice.
T5585	16352-16354	PRP	denotes	We
T5586	16355-16359	VBD	denotes	were
T5587	16360-16372	RB	denotes	particularly
T5588	16373-16383	JJ	denotes	interested
T5589	16384-16386	IN	denotes	in
T5590	16387-16398	VBG	denotes	determining
T5591	16399-16402	DT	denotes	the
T5592	16409-16415	NN	denotes	nature
T5593	16403-16408	JJ	denotes	exact
T5594	16416-16418	IN	denotes	of
T5595	16419-16422	DT	denotes	the
T5596	16439-16449	NN	denotes	expression
T5597	16423-16432	JJ	denotes	embryonic
T5598	16433-16438	NN	denotes	flank
T5599	16450-16458	JJ	denotes	relative
T5600	16459-16461	IN	denotes	to
T5601	16462-16465	DT	denotes	the
T5602	16478-16487	NN	denotes	phenotype
T5603	16466-16477	VBN	denotes	ventralized
T5604	16488-16490	IN	denotes	of
T5605	16491-16496	JJ	denotes	adult
T5606	16505-16509	NNS	denotes	mice
T5607	16497-16500	NN	denotes	deH
T5608	16501-16504	NN	denotes	deH
T5609	16500-16501	SYM	denotes	/
T5610	16509-16510	.	denotes	.
T5611	16510-16742	sentence	denotes	Transverse abdominal sections from different times during development reveal a dorsolateral band of expression in the superficial mesenchyme at E11.5 that broadens both dorsally and ventrally over the next several days (Figure 4B).
T5612	16511-16521	JJ	denotes	Transverse
T5613	16532-16540	NNS	denotes	sections
T5614	16522-16531	JJ	denotes	abdominal
T5615	16581-16587	VBP	denotes	reveal
T5616	16541-16545	IN	denotes	from
T5617	16546-16555	JJ	denotes	different
T5618	16556-16561	NNS	denotes	times
T5619	16562-16568	IN	denotes	during
T5620	16569-16580	NN	denotes	development
T5621	16588-16589	DT	denotes	a
T5622	16603-16607	NN	denotes	band
T5623	16590-16602	JJ	denotes	dorsolateral
T5624	16608-16610	IN	denotes	of
T5625	16611-16621	NN	denotes	expression
T5626	16622-16624	IN	denotes	in
T5627	16625-16628	DT	denotes	the
T5628	16641-16651	NN	denotes	mesenchyme
T5629	16629-16640	JJ	denotes	superficial
T5630	16652-16654	IN	denotes	at
T5631	16655-16660	NN	denotes	E11.5
T5632	16661-16665	WDT	denotes	that
T5633	16666-16674	VBZ	denotes	broadens
T5634	16675-16679	CC	denotes	both
T5635	16680-16688	RB	denotes	dorsally
T5636	16689-16692	CC	denotes	and
T5637	16693-16702	RB	denotes	ventrally
T5638	16703-16707	IN	denotes	over
T5639	16708-16711	DT	denotes	the
T5640	16725-16729	NNS	denotes	days
T5641	16712-16716	JJ	denotes	next
T5642	16717-16724	JJ	denotes	several
T5643	16730-16731	-LRB-	denotes	(
T5644	16731-16737	NN	denotes	Figure
T5645	16738-16740	CD	denotes	4B
T5646	16740-16741	-RRB-	denotes	)
T5647	16741-16742	.	denotes	.
T5648	16742-16940	sentence	denotes	By E13.5, the developing dermis has become separated from the loose mesenchyme by a subcutaneous muscle layer; Tbx15 is expressed in all of these layers as well as the underlying abdominal muscles.
T5649	16743-16745	IN	denotes	By
T5650	16779-16785	VBN	denotes	become
T5651	16746-16751	NN	denotes	E13.5
T5652	16751-16753	,	denotes	,
T5653	16753-16756	DT	denotes	the
T5654	16768-16774	NN	denotes	dermis
T5655	16757-16767	VBG	denotes	developing
T5656	16775-16778	VBZ	denotes	has
T5657	16863-16872	VBN	denotes	expressed
T5658	16786-16795	JJ	denotes	separated
T5659	16796-16800	IN	denotes	from
T5660	16801-16804	DT	denotes	the
T5661	16811-16821	NN	denotes	mesenchyme
T5662	16805-16810	JJ	denotes	loose
T5663	16822-16824	IN	denotes	by
T5664	16825-16826	DT	denotes	a
T5665	16847-16852	NN	denotes	layer
T5666	16827-16839	JJ	denotes	subcutaneous
T5667	16840-16846	NN	denotes	muscle
T5668	16852-16853	:	denotes	;
T5669	16854-16859	NN	denotes	Tbx15
T5670	16860-16862	VBZ	denotes	is
T5671	16873-16875	IN	denotes	in
T5672	16876-16879	DT	denotes	all
T5673	16880-16882	IN	denotes	of
T5674	16883-16888	DT	denotes	these
T5675	16889-16895	NNS	denotes	layers
T5676	16896-16898	RB	denotes	as
T5677	16904-16906	IN	denotes	as
T5678	16899-16903	RB	denotes	well
T5679	16907-16910	DT	denotes	the
T5680	16932-16939	NNS	denotes	muscles
T5681	16911-16921	VBG	denotes	underlying
T5682	16922-16931	JJ	denotes	abdominal
T5683	16939-16940	.	denotes	.
T5684	16940-17180	sentence	denotes	In P3.5 skin, Tbx15 is expressed in both dorsal and ventral skin, most strongly in the condensed upper dermis and developing dermal sheaths of hair follicles; faint expression can also be detected in rare dermal papillae cells (Figure 4B).
T5685	16941-16943	IN	denotes	In
T5686	16964-16973	VBN	denotes	expressed
T5687	16944-16948	NN	denotes	P3.5
T5688	16949-16953	NN	denotes	skin
T5689	16953-16955	,	denotes	,
T5690	16955-16960	NN	denotes	Tbx15
T5691	16961-16963	VBZ	denotes	is
T5692	17129-17137	VBN	denotes	detected
T5693	16974-16976	IN	denotes	in
T5694	16977-16981	CC	denotes	both
T5695	16982-16988	JJ	denotes	dorsal
T5696	17001-17005	NN	denotes	skin
T5697	16989-16992	CC	denotes	and
T5698	16993-17000	JJ	denotes	ventral
T5699	17005-17007	,	denotes	,
T5700	17007-17011	RBS	denotes	most
T5701	17012-17020	RB	denotes	strongly
T5702	17021-17023	IN	denotes	in
T5703	17024-17027	DT	denotes	the
T5704	17044-17050	NN	denotes	dermis
T5705	17028-17037	VBN	denotes	condensed
T5706	17038-17043	JJ	denotes	upper
T5707	17051-17054	CC	denotes	and
T5708	17055-17065	VBG	denotes	developing
T5709	17073-17080	NNS	denotes	sheaths
T5710	17066-17072	JJ	denotes	dermal
T5711	17081-17083	IN	denotes	of
T5712	17084-17088	NN	denotes	hair
T5713	17089-17098	NNS	denotes	follicles
T5714	17098-17099	:	denotes	;
T5715	17100-17105	JJ	denotes	faint
T5716	17106-17116	NN	denotes	expression
T5717	17117-17120	MD	denotes	can
T5718	17121-17125	RB	denotes	also
T5719	17126-17128	VB	denotes	be
T5720	17138-17140	IN	denotes	in
T5721	17141-17145	JJ	denotes	rare
T5722	17162-17167	NNS	denotes	cells
T5723	17146-17152	JJ	denotes	dermal
T5724	17153-17161	NNS	denotes	papillae
T5725	17168-17169	-LRB-	denotes	(
T5726	17169-17175	NN	denotes	Figure
T5727	17176-17178	CD	denotes	4B
T5728	17178-17179	-RRB-	denotes	)
T5729	17179-17180	.	denotes	.
T5730	17180-17364	sentence	denotes	Although the effects of Agouti on pigment-type switching occur during postnatal hair growth, the ventral-specific isoform of Agouti is expressed in developing skin beginning at E11.5.
T5731	17181-17189	IN	denotes	Although
T5732	17238-17243	VBP	denotes	occur
T5733	17190-17193	DT	denotes	the
T5734	17194-17201	NNS	denotes	effects
T5735	17202-17204	IN	denotes	of
T5736	17205-17211	NN	denotes	Agouti
T5737	17212-17214	IN	denotes	on
T5738	17215-17222	NN	denotes	pigment
T5739	17223-17227	NN	denotes	type
T5740	17222-17223	HYPH	denotes	-
T5741	17228-17237	VBG	denotes	switching
T5742	17316-17325	VBN	denotes	expressed
T5743	17244-17250	IN	denotes	during
T5744	17251-17260	JJ	denotes	postnatal
T5745	17266-17272	NN	denotes	growth
T5746	17261-17265	NN	denotes	hair
T5747	17272-17274	,	denotes	,
T5748	17274-17277	DT	denotes	the
T5749	17295-17302	NN	denotes	isoform
T5750	17278-17285	JJ	denotes	ventral
T5751	17286-17294	JJ	denotes	specific
T5752	17285-17286	HYPH	denotes	-
T5753	17303-17305	IN	denotes	of
T5754	17306-17312	NN	denotes	Agouti
T5755	17313-17315	VBZ	denotes	is
T5756	17326-17328	IN	denotes	in
T5757	17329-17339	VBG	denotes	developing
T5758	17340-17344	NN	denotes	skin
T5759	17345-17354	VBG	denotes	beginning
T5760	17355-17357	IN	denotes	at
T5761	17358-17363	NN	denotes	E11.5
T5762	17363-17364	.	denotes	.
T5763	17364-17585	sentence	denotes	We compared adjacent sections hybridized with probes for Tbx15 and Agouti and observed complementary patterns at E12.5, with expression of Agouti in ventral skin and expression of Tbx15 in dorsal skin (Figure 5A and 5B).
T5764	17365-17367	PRP	denotes	We
T5765	17368-17376	VBD	denotes	compared
T5766	17377-17385	JJ	denotes	adjacent
T5767	17386-17394	NNS	denotes	sections
T5768	17395-17405	VBN	denotes	hybridized
T5769	17406-17410	IN	denotes	with
T5770	17411-17417	NNS	denotes	probes
T5771	17418-17421	IN	denotes	for
T5772	17422-17427	NN	denotes	Tbx15
T5773	17428-17431	CC	denotes	and
T5774	17432-17438	NN	denotes	Agouti
T5775	17439-17442	CC	denotes	and
T5776	17443-17451	VBD	denotes	observed
T5777	17452-17465	JJ	denotes	complementary
T5778	17466-17474	NNS	denotes	patterns
T5779	17475-17477	IN	denotes	at
T5780	17478-17483	NN	denotes	E12.5
T5781	17483-17485	,	denotes	,
T5782	17485-17489	IN	denotes	with
T5783	17490-17500	NN	denotes	expression
T5784	17501-17503	IN	denotes	of
T5785	17504-17510	NN	denotes	Agouti
T5786	17511-17513	IN	denotes	in
T5787	17514-17521	JJ	denotes	ventral
T5788	17522-17526	NN	denotes	skin
T5789	17527-17530	CC	denotes	and
T5790	17531-17541	NN	denotes	expression
T5791	17542-17544	IN	denotes	of
T5792	17545-17550	NN	denotes	Tbx15
T5793	17551-17553	IN	denotes	in
T5794	17554-17560	JJ	denotes	dorsal
T5795	17561-17565	NN	denotes	skin
T5796	17566-17567	-LRB-	denotes	(
T5797	17574-17576	CD	denotes	5A
T5798	17567-17573	NN	denotes	Figure
T5799	17577-17580	CC	denotes	and
T5800	17581-17583	CD	denotes	5B
T5801	17583-17584	-RRB-	denotes	)
T5802	17584-17585	.	denotes	.
T5803	17585-17757	sentence	denotes	The junction between expression domains is indistinct, and by E14.5, Tbx15 expression extends ventrally and overlaps extensively with Agouti expression (Figure 5C and 5D).
T5804	17586-17589	DT	denotes	The
T5805	17590-17598	NN	denotes	junction
T5806	17626-17628	VBZ	denotes	is
T5807	17599-17606	IN	denotes	between
T5808	17607-17617	NN	denotes	expression
T5809	17618-17625	NNS	denotes	domains
T5810	17629-17639	JJ	denotes	indistinct
T5811	17639-17641	,	denotes	,
T5812	17641-17644	CC	denotes	and
T5813	17645-17647	IN	denotes	by
T5814	17672-17679	VBZ	denotes	extends
T5815	17648-17653	NN	denotes	E14.5
T5816	17653-17655	,	denotes	,
T5817	17655-17660	NN	denotes	Tbx15
T5818	17661-17671	NN	denotes	expression
T5819	17680-17689	RB	denotes	ventrally
T5820	17690-17693	CC	denotes	and
T5821	17694-17702	VBZ	denotes	overlaps
T5822	17703-17714	RB	denotes	extensively
T5823	17715-17719	IN	denotes	with
T5824	17720-17726	NN	denotes	Agouti
T5825	17727-17737	NN	denotes	expression
T5826	17738-17739	-LRB-	denotes	(
T5827	17746-17748	CD	denotes	5C
T5828	17739-17745	NN	denotes	Figure
T5829	17749-17752	CC	denotes	and
T5830	17753-17755	CD	denotes	5D
T5831	17755-17756	-RRB-	denotes	)
T5832	17756-17757	.	denotes	.
T5833	17757-18412	sentence	denotes	Figure 5 Embryonic Expression of Tbx15 Compared to Agouti in at/at Mice (A and C) Tbx15. (B and D) Agouti. At E12.5, expression of Tbx15 in dorsal skin is approximately complementary to that of Agouti in ventral skin. At E14.5, the levels of expression for both genes are lower, but Tbx15 expression has expanded ventrally and overlaps extensively with that of Agouti. In all four panels, arrows mark the approximate ventral limit of Tbx15 and the approximate dorsal limit of Agouti (scale bars = 500 μm). We also examined the effect of deH on expression of Agouti and found no difference between mutant and nonmutant at E12.5 or E13.5 (data not shown).
T5834	18265-18267	PRP	denotes	We
T5835	18273-18281	VBD	denotes	examined
T5836	18268-18272	RB	denotes	also
T5837	18282-18285	DT	denotes	the
T5838	18286-18292	NN	denotes	effect
T5839	18293-18295	IN	denotes	of
T5840	18296-18299	NN	denotes	deH
T5841	18300-18302	IN	denotes	on
T5842	18303-18313	NN	denotes	expression
T5843	18314-18316	IN	denotes	of
T5844	18317-18323	NN	denotes	Agouti
T5845	18324-18327	CC	denotes	and
T5846	18328-18333	VBD	denotes	found
T5847	18334-18336	DT	denotes	no
T5848	18337-18347	NN	denotes	difference
T5849	18348-18355	IN	denotes	between
T5850	18356-18362	JJ	denotes	mutant
T5851	18363-18366	CC	denotes	and
T5852	18367-18376	JJ	denotes	nonmutant
T5853	18377-18379	IN	denotes	at
T5854	18380-18385	NN	denotes	E12.5
T5855	18386-18388	CC	denotes	or
T5856	18389-18394	NN	denotes	E13.5
T5857	18395-18396	-LRB-	denotes	(
T5858	18405-18410	VBN	denotes	shown
T5859	18396-18400	NNS	denotes	data
T5860	18401-18404	RB	denotes	not
T5861	18410-18411	-RRB-	denotes	)
T5862	18411-18412	.	denotes	.
T5863	18412-18555	sentence	denotes	However, at E14.5, the normal ventral-to-dorsal gradient of Agouti expression appeared to extend more dorsally in deH/deH embryos (Figure 6A).
T5864	18413-18420	RB	denotes	However
T5865	18491-18499	VBD	denotes	appeared
T5866	18420-18422	,	denotes	,
T5867	18422-18424	IN	denotes	at
T5868	18425-18430	NN	denotes	E14.5
T5869	18430-18432	,	denotes	,
T5870	18432-18435	DT	denotes	the
T5871	18461-18469	NN	denotes	gradient
T5872	18436-18442	JJ	denotes	normal
T5873	18443-18450	JJ	denotes	ventral
T5874	18450-18451	HYPH	denotes	-
T5875	18451-18453	IN	denotes	to
T5876	18453-18454	HYPH	denotes	-
T5877	18454-18460	JJ	denotes	dorsal
T5878	18470-18472	IN	denotes	of
T5879	18473-18479	NN	denotes	Agouti
T5880	18480-18490	NN	denotes	expression
T5881	18500-18502	TO	denotes	to
T5882	18503-18509	VB	denotes	extend
T5883	18510-18514	RBR	denotes	more
T5884	18515-18523	RB	denotes	dorsally
T5885	18524-18526	IN	denotes	in
T5886	18527-18530	NN	denotes	deH
T5887	18531-18534	NN	denotes	deH
T5888	18530-18531	HYPH	denotes	/
T5889	18535-18542	NNS	denotes	embryos
T5890	18543-18544	-LRB-	denotes	(
T5891	18544-18550	NN	denotes	Figure
T5892	18551-18553	CD	denotes	6A
T5893	18553-18554	-RRB-	denotes	)
T5894	18554-18555	.	denotes	.
T5895	18555-18742	sentence	denotes	In P4.5 skin, expression of Agouti is also extended dorsally in deH/deH animals and is most apparent in the midflank region within the upper dermis and dermal papillae cells (Figure 6B).
T5896	18556-18558	IN	denotes	In
T5897	18599-18607	VBN	denotes	extended
T5898	18559-18563	NN	denotes	P4.5
T5899	18564-18568	NN	denotes	skin
T5900	18568-18570	,	denotes	,
T5901	18570-18580	NN	denotes	expression
T5902	18581-18583	IN	denotes	of
T5903	18584-18590	NN	denotes	Agouti
T5904	18591-18593	VBZ	denotes	is
T5905	18594-18598	RB	denotes	also
T5906	18608-18616	RB	denotes	dorsally
T5907	18617-18619	IN	denotes	in
T5908	18620-18623	NN	denotes	deH
T5909	18624-18627	NN	denotes	deH
T5910	18623-18624	HYPH	denotes	/
T5911	18628-18635	NNS	denotes	animals
T5912	18636-18639	CC	denotes	and
T5913	18640-18642	VBZ	denotes	is
T5914	18643-18647	RBS	denotes	most
T5915	18648-18656	JJ	denotes	apparent
T5916	18657-18659	IN	denotes	in
T5917	18660-18663	DT	denotes	the
T5918	18673-18679	NN	denotes	region
T5919	18664-18672	JJ	denotes	midflank
T5920	18680-18686	IN	denotes	within
T5921	18687-18690	DT	denotes	the
T5922	18697-18703	NN	denotes	dermis
T5923	18691-18696	JJ	denotes	upper
T5924	18704-18707	CC	denotes	and
T5925	18708-18714	JJ	denotes	dermal
T5926	18724-18729	NNS	denotes	cells
T5927	18715-18723	NNS	denotes	papillae
T5928	18730-18731	-LRB-	denotes	(
T5929	18731-18737	NN	denotes	Figure
T5930	18738-18740	CD	denotes	6B
T5931	18740-18741	-RRB-	denotes	)
T5932	18741-18742	.	denotes	.
T5933	18742-19074	sentence	denotes	Thus, while the pigmentation phenotype of deH/deH mice can be explained, not surprisingly, by dorsal extension of Agouti expression after birth, patterned expression of Tbx15 and Agouti are apparent some 10 days earlier, between E12.5 and E13.5, and the effects of Tbx15 deficiency on expression of Agouti can be detected by E14.5.
T5934	18743-18747	RB	denotes	Thus
T5935	18929-18932	VBP	denotes	are
T5936	18747-18749	,	denotes	,
T5937	18749-18754	IN	denotes	while
T5938	18805-18814	VBN	denotes	explained
T5939	18755-18758	DT	denotes	the
T5940	18772-18781	NN	denotes	phenotype
T5941	18759-18771	NN	denotes	pigmentation
T5942	18782-18784	IN	denotes	of
T5943	18785-18788	NN	denotes	deH
T5944	18789-18792	NN	denotes	deH
T5945	18788-18789	HYPH	denotes	/
T5946	18793-18797	NNS	denotes	mice
T5947	18798-18801	MD	denotes	can
T5948	18802-18804	VB	denotes	be
T5949	18814-18816	,	denotes	,
T5950	18816-18819	RB	denotes	not
T5951	18820-18832	RB	denotes	surprisingly
T5952	18832-18834	,	denotes	,
T5953	18834-18836	IN	denotes	by
T5954	18837-18843	JJ	denotes	dorsal
T5955	18844-18853	NN	denotes	extension
T5956	18854-18856	IN	denotes	of
T5957	18857-18863	NN	denotes	Agouti
T5958	18864-18874	NN	denotes	expression
T5959	18875-18880	IN	denotes	after
T5960	18881-18886	NN	denotes	birth
T5961	18886-18888	,	denotes	,
T5962	18888-18897	VBN	denotes	patterned
T5963	18898-18908	NN	denotes	expression
T5964	18909-18911	IN	denotes	of
T5965	18912-18917	NN	denotes	Tbx15
T5966	18918-18921	CC	denotes	and
T5967	18922-18928	NN	denotes	Agouti
T5968	18933-18941	JJ	denotes	apparent
T5969	18942-18946	DT	denotes	some
T5970	18947-18949	CD	denotes	10
T5971	18950-18954	NNS	denotes	days
T5972	18955-18962	RBR	denotes	earlier
T5973	18962-18964	,	denotes	,
T5974	18964-18971	IN	denotes	between
T5975	18972-18977	NN	denotes	E12.5
T5976	18978-18981	CC	denotes	and
T5977	18982-18987	NN	denotes	E13.5
T5978	18987-18989	,	denotes	,
T5979	18989-18992	CC	denotes	and
T5980	18993-18996	DT	denotes	the
T5981	18997-19004	NNS	denotes	effects
T5982	19056-19064	VBN	denotes	detected
T5983	19005-19007	IN	denotes	of
T5984	19008-19013	NN	denotes	Tbx15
T5985	19014-19024	NN	denotes	deficiency
T5986	19025-19027	IN	denotes	on
T5987	19028-19038	NN	denotes	expression
T5988	19039-19041	IN	denotes	of
T5989	19042-19048	NN	denotes	Agouti
T5990	19049-19052	MD	denotes	can
T5991	19053-19055	VB	denotes	be
T5992	19065-19067	IN	denotes	by
T5993	19068-19073	NN	denotes	E14.5
T5994	19073-19074	.	denotes	.
T6165	19703-19715	NN	denotes	Relationship
T6166	19716-19718	IN	denotes	of
T6167	19719-19728	JJ	denotes	Embryonic
T6168	19735-19745	NN	denotes	Expression
T6169	19729-19734	NN	denotes	Tbx15
T6170	19746-19748	IN	denotes	to
T6171	19749-19755	JJ	denotes	Dorsal
T6172	19781-19788	NNS	denotes	Domains
T6173	19756-19759	CC	denotes	and
T6174	19760-19767	JJ	denotes	Ventral
T6175	19768-19780	NN	denotes	Pigmentation
T6176	19788-20080	sentence	denotes	The observations described above are consistent with a model in which transient expression of Tbx15 in the embryonic dorsal flank is required to establish positional identity of the future dermis, at least with respect to pigment-type synthesis caused by the ventral-specific Agouti isoform.
T6177	19789-19792	DT	denotes	The
T6178	19793-19805	NNS	denotes	observations
T6179	19822-19825	VBP	denotes	are
T6180	19806-19815	VBN	denotes	described
T6181	19816-19821	RB	denotes	above
T6182	19826-19836	JJ	denotes	consistent
T6183	19837-19841	IN	denotes	with
T6184	19842-19843	DT	denotes	a
T6185	19844-19849	NN	denotes	model
T6186	19850-19852	IN	denotes	in
T6187	19922-19930	VBN	denotes	required
T6188	19853-19858	WDT	denotes	which
T6189	19859-19868	JJ	denotes	transient
T6190	19869-19879	NN	denotes	expression
T6191	19880-19882	IN	denotes	of
T6192	19883-19888	NN	denotes	Tbx15
T6193	19889-19891	IN	denotes	in
T6194	19892-19895	DT	denotes	the
T6195	19913-19918	NN	denotes	flank
T6196	19896-19905	JJ	denotes	embryonic
T6197	19906-19912	JJ	denotes	dorsal
T6198	19919-19921	VBZ	denotes	is
T6199	19931-19933	TO	denotes	to
T6200	19934-19943	VB	denotes	establish
T6201	19944-19954	JJ	denotes	positional
T6202	19955-19963	NN	denotes	identity
T6203	19964-19966	IN	denotes	of
T6204	19967-19970	DT	denotes	the
T6205	19978-19984	NN	denotes	dermis
T6206	19971-19977	JJ	denotes	future
T6207	19984-19986	,	denotes	,
T6208	19986-19988	RB	denotes	at
T6209	19989-19994	RBS	denotes	least
T6210	19995-19999	IN	denotes	with
T6211	20000-20007	NN	denotes	respect
T6212	20008-20010	IN	denotes	to
T6213	20011-20018	NN	denotes	pigment
T6214	20019-20023	NN	denotes	type
T6215	20018-20019	HYPH	denotes	-
T6216	20024-20033	NN	denotes	synthesis
T6217	20034-20040	VBN	denotes	caused
T6218	20041-20043	IN	denotes	by
T6219	20044-20047	DT	denotes	the
T6220	20072-20079	NN	denotes	isoform
T6221	20048-20055	JJ	denotes	ventral
T6222	20056-20064	JJ	denotes	specific
T6223	20055-20056	HYPH	denotes	-
T6224	20065-20071	NN	denotes	Agouti
T6225	20079-20080	.	denotes	.
T6226	20080-20250	sentence	denotes	To further investigate this hypothesis, we carried out transplantation experiments in which pieces of embryonic skin were isolated from different dorsoventral positions.
T6227	20081-20083	TO	denotes	To
T6228	20092-20103	VB	denotes	investigate
T6229	20084-20091	RB	denotes	further
T6230	20124-20131	VBD	denotes	carried
T6231	20104-20108	DT	denotes	this
T6232	20109-20119	NN	denotes	hypothesis
T6233	20119-20121	,	denotes	,
T6234	20121-20123	PRP	denotes	we
T6235	20132-20135	RP	denotes	out
T6236	20136-20151	NN	denotes	transplantation
T6237	20152-20163	NNS	denotes	experiments
T6238	20164-20166	IN	denotes	in
T6239	20203-20211	VBN	denotes	isolated
T6240	20167-20172	WDT	denotes	which
T6241	20173-20179	NNS	denotes	pieces
T6242	20180-20182	IN	denotes	of
T6243	20183-20192	JJ	denotes	embryonic
T6244	20193-20197	NN	denotes	skin
T6245	20198-20202	VBD	denotes	were
T6246	20212-20216	IN	denotes	from
T6247	20217-20226	JJ	denotes	different
T6248	20240-20249	NNS	denotes	positions
T6249	20227-20239	JJ	denotes	dorsoventral
T6250	20249-20250	.	denotes	.
T6251	20250-20396	sentence	denotes	We evaluated the embryonic skin fragments for their potential to give rise to different hair colors and for their expression of Tbx15 and Agouti.
T6252	20251-20253	PRP	denotes	We
T6253	20254-20263	VBD	denotes	evaluated
T6254	20264-20267	DT	denotes	the
T6255	20283-20292	NNS	denotes	fragments
T6256	20268-20277	JJ	denotes	embryonic
T6257	20278-20282	NN	denotes	skin
T6258	20293-20296	IN	denotes	for
T6259	20297-20302	PRP$	denotes	their
T6260	20303-20312	NN	denotes	potential
T6261	20313-20315	TO	denotes	to
T6262	20316-20320	VB	denotes	give
T6263	20321-20325	NN	denotes	rise
T6264	20326-20328	IN	denotes	to
T6265	20329-20338	JJ	denotes	different
T6266	20344-20350	NNS	denotes	colors
T6267	20339-20343	NN	denotes	hair
T6268	20351-20354	CC	denotes	and
T6269	20355-20358	IN	denotes	for
T6270	20359-20364	PRP$	denotes	their
T6271	20365-20375	NN	denotes	expression
T6272	20376-20378	IN	denotes	of
T6273	20379-20384	NN	denotes	Tbx15
T6274	20385-20388	CC	denotes	and
T6275	20389-20395	NN	denotes	Agouti
T6276	20395-20396	.	denotes	.
T6277	20396-20651	sentence	denotes	Previous studies by Silvers and colleagues (Poole and Silvers 1976) showed that dorsal and ventral skin isolated from at/at embryos gives rise to black and yellow hair, respectively, when transplanted into testis and allowed to develop for several weeks.
T6278	20397-20405	JJ	denotes	Previous
T6279	20406-20413	NNS	denotes	studies
T6280	20465-20471	VBD	denotes	showed
T6281	20414-20416	IN	denotes	by
T6282	20417-20424	NNP	denotes	Silvers
T6283	20425-20428	CC	denotes	and
T6284	20429-20439	NNS	denotes	colleagues
T6285	20440-20441	-LRB-	denotes	(
T6286	20441-20446	NNP	denotes	Poole
T6287	20447-20450	CC	denotes	and
T6288	20451-20458	NNP	denotes	Silvers
T6289	20459-20463	CD	denotes	1976
T6290	20463-20464	-RRB-	denotes	)
T6291	20472-20476	IN	denotes	that
T6292	20529-20534	VBZ	denotes	gives
T6293	20477-20483	JJ	denotes	dorsal
T6294	20496-20500	NN	denotes	skin
T6295	20484-20487	CC	denotes	and
T6296	20488-20495	JJ	denotes	ventral
T6297	20501-20509	VBN	denotes	isolated
T6298	20510-20514	IN	denotes	from
T6299	20515-20517	NN	denotes	at
T6300	20518-20520	NN	denotes	at
T6301	20517-20518	HYPH	denotes	/
T6302	20521-20528	NNS	denotes	embryos
T6303	20535-20539	NN	denotes	rise
T6304	20540-20542	IN	denotes	to
T6305	20543-20548	JJ	denotes	black
T6306	20560-20564	NN	denotes	hair
T6307	20549-20552	CC	denotes	and
T6308	20553-20559	JJ	denotes	yellow
T6309	20564-20566	,	denotes	,
T6310	20566-20578	RB	denotes	respectively
T6311	20578-20580	,	denotes	,
T6312	20580-20584	WRB	denotes	when
T6313	20585-20597	VBN	denotes	transplanted
T6314	20598-20602	IN	denotes	into
T6315	20603-20609	NN	denotes	testis
T6316	20610-20613	CC	denotes	and
T6317	20614-20621	VBN	denotes	allowed
T6318	20622-20624	TO	denotes	to
T6319	20625-20632	VB	denotes	develop
T6320	20633-20636	IN	denotes	for
T6321	20637-20644	JJ	denotes	several
T6322	20645-20650	NNS	denotes	weeks
T6323	20650-20651	.	denotes	.
T6324	20651-20802	sentence	denotes	Furthermore, dermal–epidermal recombination experiments carried out at E14.5 demonstrated that positional identity is carried by the embryonic dermis.
T6325	20652-20663	RB	denotes	Furthermore
T6326	20729-20741	VBD	denotes	demonstrated
T6327	20663-20665	,	denotes	,
T6328	20665-20671	JJ	denotes	dermal
T6329	20672-20681	JJ	denotes	epidermal
T6330	20671-20672	HYPH	denotes	–
T6331	20696-20707	NNS	denotes	experiments
T6332	20682-20695	NN	denotes	recombination
T6333	20708-20715	VBN	denotes	carried
T6334	20716-20719	RP	denotes	out
T6335	20720-20722	IN	denotes	at
T6336	20723-20728	NN	denotes	E14.5
T6337	20742-20746	IN	denotes	that
T6338	20770-20777	VBN	denotes	carried
T6339	20747-20757	JJ	denotes	positional
T6340	20758-20766	NN	denotes	identity
T6341	20767-20769	VBZ	denotes	is
T6342	20778-20780	IN	denotes	by
T6343	20781-20784	DT	denotes	the
T6344	20795-20801	NN	denotes	dermis
T6345	20785-20794	JJ	denotes	embryonic
T6346	20801-20802	.	denotes	.
T6347	20802-21106	sentence	denotes	In a variation on this experiment, we divided embryonic skin from at/a embryos into dorsal, flank, and ventral pieces and analyzed the different pieces for their ability to give rise to black or yellow hair after testis transplantation, and, in parallel, for gene expression using in situ hybridization.
T6348	20803-20805	IN	denotes	In
T6349	20841-20848	VBD	denotes	divided
T6350	20806-20807	DT	denotes	a
T6351	20808-20817	NN	denotes	variation
T6352	20818-20820	IN	denotes	on
T6353	20821-20825	DT	denotes	this
T6354	20826-20836	NN	denotes	experiment
T6355	20836-20838	,	denotes	,
T6356	20838-20840	PRP	denotes	we
T6357	20849-20858	JJ	denotes	embryonic
T6358	20859-20863	NN	denotes	skin
T6359	20864-20868	IN	denotes	from
T6360	20869-20871	NN	denotes	at
T6361	20872-20873	NN	denotes	a
T6362	20871-20872	HYPH	denotes	/
T6363	20874-20881	NNS	denotes	embryos
T6364	20882-20886	IN	denotes	into
T6365	20887-20893	JJ	denotes	dorsal
T6366	20914-20920	NNS	denotes	pieces
T6367	20893-20895	,	denotes	,
T6368	20895-20900	NN	denotes	flank
T6369	20900-20902	,	denotes	,
T6370	20902-20905	CC	denotes	and
T6371	20906-20913	JJ	denotes	ventral
T6372	20921-20924	CC	denotes	and
T6373	20925-20933	VBD	denotes	analyzed
T6374	20934-20937	DT	denotes	the
T6375	20948-20954	NNS	denotes	pieces
T6376	20938-20947	JJ	denotes	different
T6377	20955-20958	IN	denotes	for
T6378	20959-20964	PRP$	denotes	their
T6379	20965-20972	NN	denotes	ability
T6380	20973-20975	TO	denotes	to
T6381	20976-20980	VB	denotes	give
T6382	20981-20985	NN	denotes	rise
T6383	20986-20988	IN	denotes	to
T6384	20989-20994	JJ	denotes	black
T6385	21005-21009	NN	denotes	hair
T6386	20995-20997	CC	denotes	or
T6387	20998-21004	JJ	denotes	yellow
T6388	21010-21015	IN	denotes	after
T6389	21016-21022	NN	denotes	testis
T6390	21023-21038	NN	denotes	transplantation
T6391	21038-21040	,	denotes	,
T6392	21040-21043	CC	denotes	and
T6393	21043-21045	,	denotes	,
T6394	21058-21061	IN	denotes	for
T6395	21045-21047	IN	denotes	in
T6396	21048-21056	NN	denotes	parallel
T6397	21056-21058	,	denotes	,
T6398	21062-21066	NN	denotes	gene
T6399	21067-21077	NN	denotes	expression
T6400	21078-21083	VBG	denotes	using
T6401	21084-21086	FW	denotes	in
T6402	21087-21091	FW	denotes	situ
T6403	21092-21105	NN	denotes	hybridization
T6404	21105-21106	.	denotes	.
T6405	21106-21499	sentence	denotes	For the purposes of a reproducible morphologic boundary, we divided flank from ventral skin based on a change in skin thickness and divided dorsal from flank skin at the level of an ectodermal notch that lies at the same level as the ventral extent of the myotome (Figure 7) (Huang and Christ 2000; Olivera-Martinez et al. 2000; Sudo et al. 2001; Burke and Nowicki 2003; Nowicki et al. 2003).
T6406	21107-21110	IN	denotes	For
T6407	21167-21174	VBD	denotes	divided
T6408	21111-21114	DT	denotes	the
T6409	21115-21123	NNS	denotes	purposes
T6410	21124-21126	IN	denotes	of
T6411	21127-21128	DT	denotes	a
T6412	21154-21162	NN	denotes	boundary
T6413	21129-21141	JJ	denotes	reproducible
T6414	21142-21153	JJ	denotes	morphologic
T6415	21162-21164	,	denotes	,
T6416	21164-21166	PRP	denotes	we
T6417	21175-21180	NN	denotes	flank
T6418	21181-21185	IN	denotes	from
T6419	21186-21193	JJ	denotes	ventral
T6420	21194-21198	NN	denotes	skin
T6421	21199-21204	VBN	denotes	based
T6422	21205-21207	IN	denotes	on
T6423	21208-21209	DT	denotes	a
T6424	21210-21216	NN	denotes	change
T6425	21217-21219	IN	denotes	in
T6426	21220-21224	NN	denotes	skin
T6427	21225-21234	NN	denotes	thickness
T6428	21235-21238	CC	denotes	and
T6429	21239-21246	VBN	denotes	divided
T6430	21247-21253	JJ	denotes	dorsal
T6431	21254-21258	IN	denotes	from
T6432	21259-21264	NN	denotes	flank
T6433	21265-21269	NN	denotes	skin
T6434	21270-21272	IN	denotes	at
T6435	21273-21276	DT	denotes	the
T6436	21277-21282	NN	denotes	level
T6437	21283-21285	IN	denotes	of
T6438	21286-21288	DT	denotes	an
T6439	21300-21305	NN	denotes	notch
T6440	21289-21299	JJ	denotes	ectodermal
T6441	21306-21310	WDT	denotes	that
T6442	21311-21315	VBZ	denotes	lies
T6443	21316-21318	IN	denotes	at
T6444	21319-21322	DT	denotes	the
T6445	21328-21333	NN	denotes	level
T6446	21323-21327	JJ	denotes	same
T6447	21334-21336	IN	denotes	as
T6448	21337-21340	DT	denotes	the
T6449	21349-21355	NN	denotes	extent
T6450	21341-21348	JJ	denotes	ventral
T6451	21356-21358	IN	denotes	of
T6452	21359-21362	DT	denotes	the
T6453	21363-21370	NN	denotes	myotome
T6454	21371-21372	-LRB-	denotes	(
T6455	21372-21378	NN	denotes	Figure
T6456	21379-21380	CD	denotes	7
T6457	21380-21381	-RRB-	denotes	)
T6458	21382-21383	-LRB-	denotes	(
T6459	21383-21388	NNP	denotes	Huang
T6460	21389-21392	CC	denotes	and
T6461	21393-21399	NNP	denotes	Christ
T6462	21400-21404	CD	denotes	2000
T6463	21404-21405	:	denotes	;
T6464	21406-21413	NNP	denotes	Olivera
T6465	21413-21414	HYPH	denotes	-
T6466	21414-21422	NNP	denotes	Martinez
T6467	21423-21425	FW	denotes	et
T6468	21426-21429	FW	denotes	al.
T6469	21430-21434	CD	denotes	2000
T6470	21434-21435	:	denotes	;
T6471	21436-21440	NNP	denotes	Sudo
T6472	21441-21443	FW	denotes	et
T6473	21444-21447	FW	denotes	al.
T6474	21448-21452	CD	denotes	2001
T6475	21452-21453	:	denotes	;
T6476	21454-21459	NNP	denotes	Burke
T6477	21460-21463	CC	denotes	and
T6478	21464-21471	NNP	denotes	Nowicki
T6479	21472-21476	CD	denotes	2003
T6480	21476-21477	:	denotes	;
T6481	21478-21485	NNP	denotes	Nowicki
T6482	21486-21488	FW	denotes	et
T6483	21489-21492	FW	denotes	al.
T6484	21493-21497	CD	denotes	2003
T6485	21497-21498	-RRB-	denotes	)
T6486	21498-21499	.	denotes	.
T6487	21499-22341	sentence	denotes	Figure 7 Embryonic Establishment of Dorsoventral Skin Patterning Pieces of skin from dorsal, flank, and ventral regions of at/a E12.5 embryos were transplanted into the testes of congenic animals as described in the text. Hair color of the grafts was examined 3 wk later. Grafts of ventral embryonic skin (n = 3) produced yellow hairs, dorsal embryonic skin (n = 4) produced black hairs, and flank embryonic skin produced mostly (13 out of 15) black and yellow hairs in distinct regions as shown. In parallel, in situ hybridization studies revealed that the embryonic flank contains the boundary of expression between Agouti and Tbx15 (scale bars = 1 mm for hairs and 200 μm for in situ hybridization results). We found that E12.5 is the earliest time at which embryonic ventral skin is able to produce hair when transplanted to the testis.
T6488	22212-22214	PRP	denotes	We
T6489	22215-22220	VBD	denotes	found
T6490	22221-22225	IN	denotes	that
T6491	22232-22234	VBZ	denotes	is
T6492	22226-22231	NN	denotes	E12.5
T6493	22235-22238	DT	denotes	the
T6494	22248-22252	NN	denotes	time
T6495	22239-22247	JJS	denotes	earliest
T6496	22253-22255	IN	denotes	at
T6497	22285-22287	VBZ	denotes	is
T6498	22256-22261	WDT	denotes	which
T6499	22262-22271	JJ	denotes	embryonic
T6500	22280-22284	NN	denotes	skin
T6501	22272-22279	JJ	denotes	ventral
T6502	22288-22292	JJ	denotes	able
T6503	22293-22295	TO	denotes	to
T6504	22296-22303	VB	denotes	produce
T6505	22304-22308	NN	denotes	hair
T6506	22309-22313	WRB	denotes	when
T6507	22314-22326	VBN	denotes	transplanted
T6508	22327-22329	IN	denotes	to
T6509	22330-22333	DT	denotes	the
T6510	22334-22340	NN	denotes	testis
T6511	22340-22341	.	denotes	.
T6512	22341-22471	sentence	denotes	Of the grafts that produced hair, ventral skin gave rise to yellow hair (n = 3), and dorsal skin gave rise to black hair (n = 4).
T6513	22342-22344	IN	denotes	Of
T6514	22389-22393	VBD	denotes	gave
T6515	22345-22348	DT	denotes	the
T6516	22349-22355	NNS	denotes	grafts
T6517	22356-22360	WDT	denotes	that
T6518	22361-22369	VBD	denotes	produced
T6519	22370-22374	NN	denotes	hair
T6520	22374-22376	,	denotes	,
T6521	22376-22383	JJ	denotes	ventral
T6522	22384-22388	NN	denotes	skin
T6523	22394-22398	NN	denotes	rise
T6524	22399-22401	IN	denotes	to
T6525	22402-22408	JJ	denotes	yellow
T6526	22409-22413	NN	denotes	hair
T6527	22414-22415	-LRB-	denotes	(
T6528	22419-22420	CD	denotes	3
T6529	22415-22416	NN	denotes	n
T6530	22417-22418	SYM	denotes	=
T6531	22420-22421	-RRB-	denotes	)
T6532	22421-22423	,	denotes	,
T6533	22423-22426	CC	denotes	and
T6534	22427-22433	JJ	denotes	dorsal
T6535	22434-22438	NN	denotes	skin
T6536	22439-22443	VBD	denotes	gave
T6537	22444-22448	NN	denotes	rise
T6538	22449-22451	IN	denotes	to
T6539	22452-22457	JJ	denotes	black
T6540	22458-22462	NN	denotes	hair
T6541	22463-22464	-LRB-	denotes	(
T6542	22468-22469	CD	denotes	4
T6543	22464-22465	NN	denotes	n
T6544	22466-22467	SYM	denotes	=
T6545	22469-22470	-RRB-	denotes	)
T6546	22470-22471	.	denotes	.
T6547	22471-22689	sentence	denotes	Transplantation of flank skin gave rise to a patch of yellow hair juxtaposed against a patch of black hair in 85% of the successful grafts (n = 13); the remaining two flank grafts produced solely black or yellow hair.
T6548	22472-22487	NN	denotes	Transplantation
T6549	22502-22506	VBD	denotes	gave
T6550	22488-22490	IN	denotes	of
T6551	22491-22496	NN	denotes	flank
T6552	22497-22501	NN	denotes	skin
T6553	22652-22660	VBD	denotes	produced
T6554	22507-22511	NN	denotes	rise
T6555	22512-22514	IN	denotes	to
T6556	22515-22516	DT	denotes	a
T6557	22517-22522	NN	denotes	patch
T6558	22523-22525	IN	denotes	of
T6559	22526-22532	JJ	denotes	yellow
T6560	22533-22537	NN	denotes	hair
T6561	22538-22548	VBN	denotes	juxtaposed
T6562	22549-22556	IN	denotes	against
T6563	22557-22558	DT	denotes	a
T6564	22559-22564	NN	denotes	patch
T6565	22565-22567	IN	denotes	of
T6566	22568-22573	JJ	denotes	black
T6567	22574-22578	NN	denotes	hair
T6568	22579-22581	IN	denotes	in
T6569	22582-22584	CD	denotes	85
T6570	22584-22585	NN	denotes	%
T6571	22586-22588	IN	denotes	of
T6572	22589-22592	DT	denotes	the
T6573	22604-22610	NNS	denotes	grafts
T6574	22593-22603	JJ	denotes	successful
T6575	22611-22612	-LRB-	denotes	(
T6576	22616-22618	CD	denotes	13
T6577	22612-22613	NN	denotes	n
T6578	22614-22615	SYM	denotes	=
T6579	22618-22619	-RRB-	denotes	)
T6580	22619-22620	:	denotes	;
T6581	22621-22624	DT	denotes	the
T6582	22645-22651	NNS	denotes	grafts
T6583	22625-22634	VBG	denotes	remaining
T6584	22635-22638	CD	denotes	two
T6585	22639-22644	NN	denotes	flank
T6586	22661-22667	RB	denotes	solely
T6587	22668-22673	JJ	denotes	black
T6588	22684-22688	NN	denotes	hair
T6589	22674-22676	CC	denotes	or
T6590	22677-22683	JJ	denotes	yellow
T6591	22688-22689	.	denotes	.
T6592	22689-22756	sentence	denotes	In no case did we observe intermingling of black and yellow hairs.
T6593	22690-22692	IN	denotes	In
T6594	22708-22715	VBP	denotes	observe
T6595	22693-22695	DT	denotes	no
T6596	22696-22700	NN	denotes	case
T6597	22701-22704	VBD	denotes	did
T6598	22705-22707	PRP	denotes	we
T6599	22716-22729	VBG	denotes	intermingling
T6600	22730-22732	IN	denotes	of
T6601	22733-22738	JJ	denotes	black
T6602	22750-22755	NNS	denotes	hairs
T6603	22739-22742	CC	denotes	and
T6604	22743-22749	JJ	denotes	yellow
T6605	22755-22756	.	denotes	.
T6606	22756-22937	sentence	denotes	As predicted from the experiments using tissue sections (see Figures 5 and 6), dorsal pieces expressed Tbx15 but not Agouti, while flank pieces expressed both genes (see Figure 7).
T6607	22757-22759	IN	denotes	As
T6608	22760-22769	VBN	denotes	predicted
T6609	22850-22859	VBD	denotes	expressed
T6610	22770-22774	IN	denotes	from
T6611	22775-22778	DT	denotes	the
T6612	22779-22790	NNS	denotes	experiments
T6613	22791-22796	VBG	denotes	using
T6614	22797-22803	NN	denotes	tissue
T6615	22804-22812	NNS	denotes	sections
T6616	22813-22814	-LRB-	denotes	(
T6617	22814-22817	VB	denotes	see
T6618	22818-22825	NNS	denotes	Figures
T6619	22826-22827	CD	denotes	5
T6620	22828-22831	CC	denotes	and
T6621	22832-22833	CD	denotes	6
T6622	22833-22834	-RRB-	denotes	)
T6623	22834-22836	,	denotes	,
T6624	22836-22842	JJ	denotes	dorsal
T6625	22843-22849	NNS	denotes	pieces
T6626	22860-22865	NN	denotes	Tbx15
T6627	22866-22869	CC	denotes	but
T6628	22870-22873	RB	denotes	not
T6629	22874-22880	NN	denotes	Agouti
T6630	22880-22882	,	denotes	,
T6631	22882-22887	IN	denotes	while
T6632	22901-22910	VBD	denotes	expressed
T6633	22888-22893	NN	denotes	flank
T6634	22894-22900	NNS	denotes	pieces
T6635	22911-22915	DT	denotes	both
T6636	22916-22921	NNS	denotes	genes
T6637	22922-22923	-LRB-	denotes	(
T6638	22923-22926	VB	denotes	see
T6639	22927-22933	NN	denotes	Figure
T6640	22934-22935	CD	denotes	7
T6641	22935-22936	-RRB-	denotes	)
T6642	22936-22937	.	denotes	.
T6643	22937-23270	sentence	denotes	Thus, dorsoventral identity for adult pigmentation is established by the time when patterned expression becomes apparent for Tbx15 and Agouti (E11.5–E12.5); furthermore, positional identity is maintained throughout later stages of skin development, even though expression of Tbx15 broadens to include ventral as well as dorsal skin.
T6644	22938-22942	RB	denotes	Thus
T6645	22992-23003	VBN	denotes	established
T6646	22942-22944	,	denotes	,
T6647	22944-22956	JJ	denotes	dorsoventral
T6648	22957-22965	NN	denotes	identity
T6649	22966-22969	IN	denotes	for
T6650	22970-22975	JJ	denotes	adult
T6651	22976-22988	NN	denotes	pigmentation
T6652	22989-22991	VBZ	denotes	is
T6653	23131-23141	VBN	denotes	maintained
T6654	23004-23006	IN	denotes	by
T6655	23007-23010	DT	denotes	the
T6656	23011-23015	NN	denotes	time
T6657	23016-23020	WRB	denotes	when
T6658	23042-23049	VBZ	denotes	becomes
T6659	23021-23030	VBN	denotes	patterned
T6660	23031-23041	NN	denotes	expression
T6661	23050-23058	JJ	denotes	apparent
T6662	23059-23062	IN	denotes	for
T6663	23063-23068	NN	denotes	Tbx15
T6664	23069-23072	CC	denotes	and
T6665	23073-23079	NN	denotes	Agouti
T6666	23080-23081	-LRB-	denotes	(
T6667	23081-23086	NN	denotes	E11.5
T6668	23086-23087	SYM	denotes	–
T6669	23087-23092	NN	denotes	E12.5
T6670	23092-23093	-RRB-	denotes	)
T6671	23093-23094	:	denotes	;
T6672	23095-23106	RB	denotes	furthermore
T6673	23106-23108	,	denotes	,
T6674	23108-23118	JJ	denotes	positional
T6675	23119-23127	NN	denotes	identity
T6676	23128-23130	VBZ	denotes	is
T6677	23142-23152	IN	denotes	throughout
T6678	23153-23158	JJ	denotes	later
T6679	23159-23165	NNS	denotes	stages
T6680	23166-23168	IN	denotes	of
T6681	23169-23173	NN	denotes	skin
T6682	23174-23185	NN	denotes	development
T6683	23185-23187	,	denotes	,
T6684	23187-23191	RB	denotes	even
T6685	23219-23227	VBZ	denotes	broadens
T6686	23192-23198	IN	denotes	though
T6687	23199-23209	NN	denotes	expression
T6688	23210-23212	IN	denotes	of
T6689	23213-23218	NN	denotes	Tbx15
T6690	23228-23230	TO	denotes	to
T6691	23231-23238	VB	denotes	include
T6692	23239-23246	JJ	denotes	ventral
T6693	23265-23269	NN	denotes	skin
T6694	23247-23249	RB	denotes	as
T6695	23255-23257	IN	denotes	as
T6696	23250-23254	RB	denotes	well
T6697	23258-23264	JJ	denotes	dorsal
T6698	23269-23270	.	denotes	.
T6883	23272-23284	NN	denotes	Relationship
T6884	23285-23287	IN	denotes	of
T6885	23288-23291	DT	denotes	the
T6886	23313-23321	NN	denotes	Boundary
T6887	23292-23304	JJ	denotes	Dorsoventral
T6888	23305-23312	NN	denotes	Pigment
T6889	23322-23324	IN	denotes	to
T6890	23325-23332	NN	denotes	Lineage
T6891	23333-23345	NNS	denotes	Compartments
T6892	23346-23349	CC	denotes	and
T6893	23350-23353	DT	denotes	the
T6894	23370-23378	NN	denotes	Frontier
T6895	23354-23361	JJ	denotes	Lateral
T6896	23362-23369	JJ	denotes	Somitic
T6897	23378-23529	sentence	denotes	The ectodermal notch that we used to mark the boundary between embryonic dorsum and embryonic flank is a characteristic feature in vertebrate embryos.
T6898	23379-23382	DT	denotes	The
T6899	23394-23399	NN	denotes	notch
T6900	23383-23393	JJ	denotes	ectodermal
T6901	23479-23481	VBZ	denotes	is
T6902	23400-23404	WDT	denotes	that
T6903	23408-23412	VBD	denotes	used
T6904	23405-23407	PRP	denotes	we
T6905	23413-23415	TO	denotes	to
T6906	23416-23420	VB	denotes	mark
T6907	23421-23424	DT	denotes	the
T6908	23425-23433	NN	denotes	boundary
T6909	23434-23441	IN	denotes	between
T6910	23442-23451	JJ	denotes	embryonic
T6911	23452-23458	NN	denotes	dorsum
T6912	23459-23462	CC	denotes	and
T6913	23463-23472	JJ	denotes	embryonic
T6914	23473-23478	NN	denotes	flank
T6915	23482-23483	DT	denotes	a
T6916	23499-23506	NN	denotes	feature
T6917	23484-23498	JJ	denotes	characteristic
T6918	23507-23509	IN	denotes	in
T6919	23510-23520	NN	denotes	vertebrate
T6920	23521-23528	NNS	denotes	embryos
T6921	23528-23529	.	denotes	.
T6922	23529-23872	sentence	denotes	In cell lineage studies carried out in the chick system, the notch serves as a landmark for the boundary between dermis derived from somitic mesoderm and dermis derived from lateral plate mesoderm and has been termed the “lateral somitic frontier” (Olivera-Martinez et al. 2000; Sudo et al. 2001; Burke and Nowicki 2003; Nowicki et al. 2003).
T6923	23530-23532	IN	denotes	In
T6924	23597-23603	VBZ	denotes	serves
T6925	23533-23537	NN	denotes	cell
T6926	23546-23553	NNS	denotes	studies
T6927	23538-23545	NN	denotes	lineage
T6928	23554-23561	VBN	denotes	carried
T6929	23562-23565	RP	denotes	out
T6930	23566-23568	IN	denotes	in
T6931	23569-23572	DT	denotes	the
T6932	23579-23585	NN	denotes	system
T6933	23573-23578	NN	denotes	chick
T6934	23585-23587	,	denotes	,
T6935	23587-23590	DT	denotes	the
T6936	23591-23596	NN	denotes	notch
T6937	23604-23606	IN	denotes	as
T6938	23607-23608	DT	denotes	a
T6939	23609-23617	NN	denotes	landmark
T6940	23618-23621	IN	denotes	for
T6941	23622-23625	DT	denotes	the
T6942	23626-23634	NN	denotes	boundary
T6943	23635-23642	IN	denotes	between
T6944	23643-23649	NN	denotes	dermis
T6945	23650-23657	VBN	denotes	derived
T6946	23658-23662	IN	denotes	from
T6947	23663-23670	JJ	denotes	somitic
T6948	23671-23679	NN	denotes	mesoderm
T6949	23680-23683	CC	denotes	and
T6950	23684-23690	NN	denotes	dermis
T6951	23691-23698	VBN	denotes	derived
T6952	23699-23703	IN	denotes	from
T6953	23704-23711	JJ	denotes	lateral
T6954	23712-23717	NN	denotes	plate
T6955	23718-23726	NN	denotes	mesoderm
T6956	23727-23730	CC	denotes	and
T6957	23731-23734	VBZ	denotes	has
T6958	23740-23746	VBN	denotes	termed
T6959	23735-23739	VBN	denotes	been
T6960	23747-23750	DT	denotes	the
T6961	23768-23776	NN	denotes	frontier
T6962	23751-23752	``	denotes	“
T6963	23752-23759	JJ	denotes	lateral
T6964	23760-23767	JJ	denotes	somitic
T6965	23776-23777	''	denotes	”
T6966	23778-23779	-LRB-	denotes	(
T6967	23779-23786	NNP	denotes	Olivera
T6968	23786-23787	HYPH	denotes	-
T6969	23787-23795	NNP	denotes	Martinez
T6970	23796-23798	FW	denotes	et
T6971	23799-23802	FW	denotes	al.
T6972	23803-23807	CD	denotes	2000
T6973	23807-23808	:	denotes	;
T6974	23809-23813	NNP	denotes	Sudo
T6975	23814-23816	FW	denotes	et
T6976	23817-23820	FW	denotes	al.
T6977	23821-23825	CD	denotes	2001
T6978	23825-23826	:	denotes	;
T6979	23827-23832	NNP	denotes	Burke
T6980	23833-23836	CC	denotes	and
T6981	23837-23844	NNP	denotes	Nowicki
T6982	23845-23849	CD	denotes	2003
T6983	23849-23850	:	denotes	;
T6984	23851-23858	NNP	denotes	Nowicki
T6985	23859-23861	FW	denotes	et
T6986	23862-23865	FW	denotes	al.
T6987	23866-23870	CD	denotes	2003
T6988	23870-23871	-RRB-	denotes	)
T6989	23871-23872	.	denotes	.
T6990	23872-24099	sentence	denotes	Although fate-mapping studies have not been carried out in mammalian embryos, somite- and lateral plate-derived mesoderm could give rise to precursors for dermis dorsal and ventral to the limb–body wall junction, respectively.
T6991	23873-23881	IN	denotes	Although
T6992	23917-23924	VBN	denotes	carried
T6993	23882-23886	NN	denotes	fate
T6994	23887-23894	VBG	denotes	mapping
T6995	23886-23887	HYPH	denotes	-
T6996	23895-23902	NNS	denotes	studies
T6997	23903-23907	VBP	denotes	have
T6998	23908-23911	RB	denotes	not
T6999	23912-23916	VBN	denotes	been
T7000	24000-24004	VB	denotes	give
T7001	23925-23928	RP	denotes	out
T7002	23929-23931	IN	denotes	in
T7003	23932-23941	JJ	denotes	mammalian
T7004	23942-23949	NNS	denotes	embryos
T7005	23949-23951	,	denotes	,
T7006	23951-23957	NN	denotes	somite
T7007	23977-23984	VBN	denotes	derived
T7008	23957-23958	HYPH	denotes	-
T7009	23959-23962	CC	denotes	and
T7010	23963-23970	JJ	denotes	lateral
T7011	23971-23976	NN	denotes	plate
T7012	23976-23977	HYPH	denotes	-
T7013	23985-23993	NN	denotes	mesoderm
T7014	23994-23999	MD	denotes	could
T7015	24005-24009	NN	denotes	rise
T7016	24010-24012	IN	denotes	to
T7017	24013-24023	NNS	denotes	precursors
T7018	24024-24027	IN	denotes	for
T7019	24028-24034	NN	denotes	dermis
T7020	24035-24041	JJ	denotes	dorsal
T7021	24042-24045	CC	denotes	and
T7022	24046-24053	JJ	denotes	ventral
T7023	24054-24056	IN	denotes	to
T7024	24057-24060	DT	denotes	the
T7025	24076-24084	NN	denotes	junction
T7026	24061-24065	NN	denotes	limb
T7027	24065-24066	HYPH	denotes	–
T7028	24066-24070	NN	denotes	body
T7029	24071-24075	NN	denotes	wall
T7030	24084-24086	,	denotes	,
T7031	24086-24098	RB	denotes	respectively
T7032	24098-24099	.	denotes	.
T7033	24099-24242	sentence	denotes	However, this notion conflicts with our observation that the future pigmentation boundary lies ventral to the ectodermal notch (see Figure 7).
T7034	24100-24107	RB	denotes	However
T7035	24121-24130	VBZ	denotes	conflicts
T7036	24107-24109	,	denotes	,
T7037	24109-24113	DT	denotes	this
T7038	24114-24120	NN	denotes	notion
T7039	24131-24135	IN	denotes	with
T7040	24136-24139	PRP$	denotes	our
T7041	24140-24151	NN	denotes	observation
T7042	24152-24156	IN	denotes	that
T7043	24190-24194	VBZ	denotes	lies
T7044	24157-24160	DT	denotes	the
T7045	24181-24189	NN	denotes	boundary
T7046	24161-24167	JJ	denotes	future
T7047	24168-24180	NN	denotes	pigmentation
T7048	24195-24202	RB	denotes	ventral
T7049	24203-24205	IN	denotes	to
T7050	24206-24209	DT	denotes	the
T7051	24221-24226	NN	denotes	notch
T7052	24210-24220	JJ	denotes	ectodermal
T7053	24227-24228	-LRB-	denotes	(
T7054	24228-24231	VB	denotes	see
T7055	24232-24238	NN	denotes	Figure
T7056	24239-24240	CD	denotes	7
T7057	24240-24241	-RRB-	denotes	)
T7058	24241-24242	.	denotes	.
T7059	24242-24484	sentence	denotes	To examine directly the relationship between the pigmentation boundary and dermis derived from lateral plate mesoderm, we made use of a Cre transgene driven by the Hoxb6 promoter that was developed by Kuehn and colleagues (Lowe et al. 2000).
T7060	24243-24245	TO	denotes	To
T7061	24246-24253	VB	denotes	examine
T7062	24365-24369	VBD	denotes	made
T7063	24254-24262	RB	denotes	directly
T7064	24263-24266	DT	denotes	the
T7065	24267-24279	NN	denotes	relationship
T7066	24280-24287	IN	denotes	between
T7067	24288-24291	DT	denotes	the
T7068	24305-24313	NN	denotes	boundary
T7069	24292-24304	NN	denotes	pigmentation
T7070	24314-24317	CC	denotes	and
T7071	24318-24324	NN	denotes	dermis
T7072	24325-24332	VBN	denotes	derived
T7073	24333-24337	IN	denotes	from
T7074	24338-24345	JJ	denotes	lateral
T7075	24346-24351	NN	denotes	plate
T7076	24352-24360	NN	denotes	mesoderm
T7077	24360-24362	,	denotes	,
T7078	24362-24364	PRP	denotes	we
T7079	24370-24373	NN	denotes	use
T7080	24374-24376	IN	denotes	of
T7081	24377-24378	DT	denotes	a
T7082	24383-24392	NN	denotes	transgene
T7083	24379-24382	NN	denotes	Cre
T7084	24393-24399	VBN	denotes	driven
T7085	24400-24402	IN	denotes	by
T7086	24403-24406	DT	denotes	the
T7087	24413-24421	NN	denotes	promoter
T7088	24407-24412	NN	denotes	Hoxb6
T7089	24422-24426	WDT	denotes	that
T7090	24431-24440	VBN	denotes	developed
T7091	24427-24430	VBD	denotes	was
T7092	24441-24443	IN	denotes	by
T7093	24444-24449	NNP	denotes	Kuehn
T7094	24450-24453	CC	denotes	and
T7095	24454-24464	NNS	denotes	colleagues
T7096	24465-24466	-LRB-	denotes	(
T7097	24466-24470	NNP	denotes	Lowe
T7098	24471-24473	FW	denotes	et
T7099	24474-24477	FW	denotes	al.
T7100	24478-24482	CD	denotes	2000
T7101	24482-24483	-RRB-	denotes	)
T7102	24483-24484	.	denotes	.
T7103	24484-24721	sentence	denotes	As described by Lowe et al. (2000), midgestation embryos carrying both the Hoxb6-Cre transgene and the R26R lacZ reporter gene (Soriano 1999) exhibit X-Gal staining in lateral plate mesoderm but not somite-derived mesoderm of the trunk.
T7104	24485-24487	IN	denotes	As
T7105	24488-24497	VBN	denotes	described
T7106	24627-24634	VBP	denotes	exhibit
T7107	24498-24500	IN	denotes	by
T7108	24501-24505	NNP	denotes	Lowe
T7109	24506-24508	FW	denotes	et
T7110	24509-24512	FW	denotes	al.
T7111	24513-24514	-LRB-	denotes	(
T7112	24514-24518	CD	denotes	2000
T7113	24518-24519	-RRB-	denotes	)
T7114	24519-24521	,	denotes	,
T7115	24521-24533	NN	denotes	midgestation
T7116	24534-24541	NNS	denotes	embryos
T7117	24542-24550	VBG	denotes	carrying
T7118	24551-24555	CC	denotes	both
T7119	24570-24579	NN	denotes	transgene
T7120	24556-24559	DT	denotes	the
T7121	24560-24565	NN	denotes	Hoxb6
T7122	24566-24569	NN	denotes	Cre
T7123	24565-24566	HYPH	denotes	-
T7124	24580-24583	CC	denotes	and
T7125	24584-24587	DT	denotes	the
T7126	24607-24611	NN	denotes	gene
T7127	24588-24592	NN	denotes	R26R
T7128	24593-24597	NN	denotes	lacZ
T7129	24598-24606	NN	denotes	reporter
T7130	24612-24613	-LRB-	denotes	(
T7131	24613-24620	NNP	denotes	Soriano
T7132	24621-24625	CD	denotes	1999
T7133	24625-24626	-RRB-	denotes	)
T7134	24635-24636	NN	denotes	X
T7135	24637-24640	NN	denotes	Gal
T7136	24636-24637	HYPH	denotes	-
T7137	24641-24649	NN	denotes	staining
T7138	24650-24652	IN	denotes	in
T7139	24653-24660	JJ	denotes	lateral
T7140	24661-24666	NN	denotes	plate
T7141	24667-24675	NN	denotes	mesoderm
T7142	24676-24679	CC	denotes	but
T7143	24680-24683	RB	denotes	not
T7144	24684-24690	NN	denotes	somite
T7145	24691-24698	VBN	denotes	derived
T7146	24690-24691	HYPH	denotes	-
T7147	24699-24707	NN	denotes	mesoderm
T7148	24708-24710	IN	denotes	of
T7149	24711-24714	DT	denotes	the
T7150	24715-24720	NN	denotes	trunk
T7151	24720-24721	.	denotes	.
T7152	24721-24948	sentence	denotes	In whole-mount skin preparations from P1.5 or P4.5 neonatal animals, we observed a ventral band of dark X-Gal staining corresponding to lateral plate-derived dermis, which represents 63% of the total circumference (Figure 8A).
T7153	24722-24724	IN	denotes	In
T7154	24794-24802	VBD	denotes	observed
T7155	24725-24730	JJ	denotes	whole
T7156	24731-24736	NN	denotes	mount
T7157	24730-24731	HYPH	denotes	-
T7158	24742-24754	NNS	denotes	preparations
T7159	24737-24741	NN	denotes	skin
T7160	24755-24759	IN	denotes	from
T7161	24760-24764	NN	denotes	P1.5
T7162	24782-24789	NNS	denotes	animals
T7163	24765-24767	CC	denotes	or
T7164	24768-24772	NN	denotes	P4.5
T7165	24773-24781	JJ	denotes	neonatal
T7166	24789-24791	,	denotes	,
T7167	24791-24793	PRP	denotes	we
T7168	24803-24804	DT	denotes	a
T7169	24813-24817	NN	denotes	band
T7170	24805-24812	JJ	denotes	ventral
T7171	24818-24820	IN	denotes	of
T7172	24821-24825	JJ	denotes	dark
T7173	24832-24840	NN	denotes	staining
T7174	24826-24827	NN	denotes	X
T7175	24827-24828	HYPH	denotes	-
T7176	24828-24831	NN	denotes	Gal
T7177	24841-24854	VBG	denotes	corresponding
T7178	24855-24857	IN	denotes	to
T7179	24858-24865	JJ	denotes	lateral
T7180	24866-24871	NN	denotes	plate
T7181	24872-24879	VBN	denotes	derived
T7182	24871-24872	HYPH	denotes	-
T7183	24880-24886	NN	denotes	dermis
T7184	24886-24888	,	denotes	,
T7185	24888-24893	WDT	denotes	which
T7186	24894-24904	VBZ	denotes	represents
T7187	24905-24907	CD	denotes	63
T7188	24907-24908	NN	denotes	%
T7189	24909-24911	IN	denotes	of
T7190	24912-24915	DT	denotes	the
T7191	24922-24935	NN	denotes	circumference
T7192	24916-24921	JJ	denotes	total
T7193	24936-24937	-LRB-	denotes	(
T7194	24937-24943	NN	denotes	Figure
T7195	24944-24946	CD	denotes	8A
T7196	24946-24947	-RRB-	denotes	)
T7197	24947-24948	.	denotes	.
T7198	24948-25231	sentence	denotes	However, in parallel preparations from at/at mice, the ventral pheomelanin domain represents 47% of the total skin circumference; therefore, the proportions of total skin circumference occupied by dorsal eumelanin and somite-derived dermis are 53% and 37%, respectively (Figure 8B).
T7199	24949-24956	RB	denotes	However
T7200	25031-25041	VBZ	denotes	represents
T7201	24956-24958	,	denotes	,
T7202	24958-24960	IN	denotes	in
T7203	24961-24969	JJ	denotes	parallel
T7204	24970-24982	NNS	denotes	preparations
T7205	24983-24987	IN	denotes	from
T7206	24988-24990	NN	denotes	at
T7207	24991-24993	NN	denotes	at
T7208	24990-24991	HYPH	denotes	/
T7209	24994-24998	NNS	denotes	mice
T7210	24998-25000	,	denotes	,
T7211	25000-25003	DT	denotes	the
T7212	25024-25030	NN	denotes	domain
T7213	25004-25011	JJ	denotes	ventral
T7214	25012-25023	NN	denotes	pheomelanin
T7215	25189-25192	VBP	denotes	are
T7216	25042-25044	CD	denotes	47
T7217	25044-25045	NN	denotes	%
T7218	25046-25048	IN	denotes	of
T7219	25049-25052	DT	denotes	the
T7220	25064-25077	NN	denotes	circumference
T7221	25053-25058	JJ	denotes	total
T7222	25059-25063	NN	denotes	skin
T7223	25077-25078	:	denotes	;
T7224	25079-25088	RB	denotes	therefore
T7225	25088-25090	,	denotes	,
T7226	25090-25093	DT	denotes	the
T7227	25094-25105	NNS	denotes	proportions
T7228	25106-25108	IN	denotes	of
T7229	25109-25114	JJ	denotes	total
T7230	25120-25133	NN	denotes	circumference
T7231	25115-25119	NN	denotes	skin
T7232	25134-25142	VBN	denotes	occupied
T7233	25143-25145	IN	denotes	by
T7234	25146-25152	JJ	denotes	dorsal
T7235	25153-25162	NN	denotes	eumelanin
T7236	25182-25188	NN	denotes	dermis
T7237	25163-25166	CC	denotes	and
T7238	25167-25173	NN	denotes	somite
T7239	25174-25181	VBN	denotes	derived
T7240	25173-25174	HYPH	denotes	-
T7241	25193-25195	CD	denotes	53
T7242	25195-25196	NN	denotes	%
T7243	25197-25200	CC	denotes	and
T7244	25201-25203	CD	denotes	37
T7245	25203-25204	NN	denotes	%
T7246	25204-25206	,	denotes	,
T7247	25206-25218	RB	denotes	respectively
T7248	25219-25220	-LRB-	denotes	(
T7249	25220-25226	NN	denotes	Figure
T7250	25227-25229	CD	denotes	8B
T7251	25229-25230	-RRB-	denotes	)
T7252	25230-25231	.	denotes	.
T7253	25231-25395	sentence	denotes	These results indicate that the pigmentation boundary is clearly distinct from, and more ventral to, the boundary between lateral plate- and somite-derived dermis.
T7254	25232-25237	DT	denotes	These
T7255	25238-25245	NNS	denotes	results
T7256	25246-25254	VBP	denotes	indicate
T7257	25255-25259	IN	denotes	that
T7258	25286-25288	VBZ	denotes	is
T7259	25260-25263	DT	denotes	the
T7260	25277-25285	NN	denotes	boundary
T7261	25264-25276	NN	denotes	pigmentation
T7262	25289-25296	RB	denotes	clearly
T7263	25297-25305	JJ	denotes	distinct
T7264	25306-25310	IN	denotes	from
T7265	25310-25312	,	denotes	,
T7266	25312-25315	CC	denotes	and
T7267	25316-25320	RBR	denotes	more
T7268	25321-25328	JJ	denotes	ventral
T7269	25329-25331	IN	denotes	to
T7270	25331-25333	,	denotes	,
T7271	25333-25336	DT	denotes	the
T7272	25337-25345	NN	denotes	boundary
T7273	25346-25353	IN	denotes	between
T7274	25354-25361	JJ	denotes	lateral
T7275	25362-25367	NN	denotes	plate
T7276	25380-25387	VBN	denotes	derived
T7277	25367-25368	HYPH	denotes	-
T7278	25369-25372	CC	denotes	and
T7279	25373-25379	NN	denotes	somite
T7280	25379-25380	HYPH	denotes	-
T7281	25388-25394	NN	denotes	dermis
T7282	25394-25395	.	denotes	.
T7283	25395-26671	sentence	denotes	Figure 8 Comparison of the Dorsoventral at/at Pigmentation Boundary to the Lateral Somitic Frontier (A) Dorsoventral slices of skin from at the midtrunk region prepared such that the dorsal midline lies in the center of the slice. Sections were taken at P1.5 (a) or P4.5 (b–e) from at/at or R26R/+; Tg.Hoxb6-Cre/+ mice (the latter were stained with X-Gal), as described in Materials and Methods. For purposes of comparison, images were proportionally scaled. The boundary of X-Gal staining marks dermis derived from lateral plate versus dermis derived from mesoderm (the lateral somitic frontier) and lies more dorsal than the at/at pigmentation boundary. (B) Quantitation of mean (± SEM) dorsal pigmentation area (n = 5) and somite-derived dermis area (n = 3) shows a significant difference (p < 0.005, t-test). (C) RNA in situ hybridization showing that Tbx15 expression at E11.5 is complementary to En1 expression on the flank (scale bars = 200 μm). The arrow indicates the boundary between the expression domains of the two genes. Because the pigmentation boundary lies in register with the limb–body wall junction (see Figure 2), we wondered whether mechanisms used for dorsoventral limb patterning might be related to those used to establish the pigmentation boundary.
T7284	26432-26439	IN	denotes	Because
T7285	26466-26470	VBZ	denotes	lies
T7286	26440-26443	DT	denotes	the
T7287	26457-26465	NN	denotes	boundary
T7288	26444-26456	NN	denotes	pigmentation
T7289	26535-26543	VBD	denotes	wondered
T7290	26471-26473	IN	denotes	in
T7291	26474-26482	NN	denotes	register
T7292	26483-26487	IN	denotes	with
T7293	26488-26491	DT	denotes	the
T7294	26507-26515	NN	denotes	junction
T7295	26492-26496	NN	denotes	limb
T7296	26496-26497	HYPH	denotes	–
T7297	26497-26501	NN	denotes	body
T7298	26502-26506	NN	denotes	wall
T7299	26516-26517	-LRB-	denotes	(
T7300	26517-26520	VB	denotes	see
T7301	26521-26527	NN	denotes	Figure
T7302	26528-26529	CD	denotes	2
T7303	26529-26530	-RRB-	denotes	)
T7304	26530-26532	,	denotes	,
T7305	26532-26534	PRP	denotes	we
T7306	26544-26551	IN	denotes	whether
T7307	26607-26609	VB	denotes	be
T7308	26552-26562	NNS	denotes	mechanisms
T7309	26563-26567	VBN	denotes	used
T7310	26568-26571	IN	denotes	for
T7311	26572-26584	JJ	denotes	dorsoventral
T7312	26590-26600	NN	denotes	patterning
T7313	26585-26589	NN	denotes	limb
T7314	26601-26606	MD	denotes	might
T7315	26610-26617	JJ	denotes	related
T7316	26618-26620	IN	denotes	to
T7317	26621-26626	DT	denotes	those
T7318	26627-26631	VBN	denotes	used
T7319	26632-26634	TO	denotes	to
T7320	26635-26644	VB	denotes	establish
T7321	26645-26648	DT	denotes	the
T7322	26662-26670	NN	denotes	boundary
T7323	26649-26661	NN	denotes	pigmentation
T7324	26670-26671	.	denotes	.
T7325	26671-26861	sentence	denotes	In the developing limb, Engrailed1 (En1), Wnt7a, and Lmx1b are part of a network whose restricted domains of expression help to establish dorsoventral identity (reviewed in Niswander 2003).
T7326	26672-26674	IN	denotes	In
T7327	26731-26734	VBP	denotes	are
T7328	26675-26678	DT	denotes	the
T7329	26690-26694	NN	denotes	limb
T7330	26679-26689	VBG	denotes	developing
T7331	26694-26696	,	denotes	,
T7332	26696-26706	NN	denotes	Engrailed1
T7333	26707-26708	-LRB-	denotes	(
T7334	26708-26711	NN	denotes	En1
T7335	26711-26712	-RRB-	denotes	)
T7336	26712-26714	,	denotes	,
T7337	26714-26719	NN	denotes	Wnt7a
T7338	26719-26721	,	denotes	,
T7339	26721-26724	CC	denotes	and
T7340	26725-26730	NN	denotes	Lmx1b
T7341	26735-26739	NN	denotes	part
T7342	26740-26742	IN	denotes	of
T7343	26743-26744	DT	denotes	a
T7344	26745-26752	NN	denotes	network
T7345	26753-26758	WP$	denotes	whose
T7346	26770-26777	NNS	denotes	domains
T7347	26759-26769	JJ	denotes	restricted
T7348	26792-26796	VBP	denotes	help
T7349	26778-26780	IN	denotes	of
T7350	26781-26791	NN	denotes	expression
T7351	26797-26799	TO	denotes	to
T7352	26800-26809	VB	denotes	establish
T7353	26810-26822	JJ	denotes	dorsoventral
T7354	26823-26831	NN	denotes	identity
T7355	26832-26833	-LRB-	denotes	(
T7356	26833-26841	VBN	denotes	reviewed
T7357	26842-26844	IN	denotes	in
T7358	26845-26854	NNP	denotes	Niswander
T7359	26855-26859	CD	denotes	2003
T7360	26859-26860	-RRB-	denotes	)
T7361	26860-26861	.	denotes	.
T7362	26861-27056	sentence	denotes	En1 is transiently expressed in the developing flank; at E11.5, transverse abdominal sections reveal domains in the neural tube, somite-derived mesenchyme, and the ventral body wall (Figure 8C).
T7363	26862-26865	NN	denotes	En1
T7364	26881-26890	VBN	denotes	expressed
T7365	26866-26868	VBZ	denotes	is
T7366	26869-26880	RB	denotes	transiently
T7367	26956-26962	VBP	denotes	reveal
T7368	26891-26893	IN	denotes	in
T7369	26894-26897	DT	denotes	the
T7370	26909-26914	NN	denotes	flank
T7371	26898-26908	VBG	denotes	developing
T7372	26914-26915	:	denotes	;
T7373	26916-26918	IN	denotes	at
T7374	26919-26924	NN	denotes	E11.5
T7375	26924-26926	,	denotes	,
T7376	26926-26936	JJ	denotes	transverse
T7377	26947-26955	NNS	denotes	sections
T7378	26937-26946	JJ	denotes	abdominal
T7379	26963-26970	NNS	denotes	domains
T7380	26971-26973	IN	denotes	in
T7381	26974-26977	DT	denotes	the
T7382	26985-26989	NN	denotes	tube
T7383	26978-26984	JJ	denotes	neural
T7384	26989-26991	,	denotes	,
T7385	26991-26997	NN	denotes	somite
T7386	26998-27005	VBN	denotes	derived
T7387	26997-26998	HYPH	denotes	-
T7388	27006-27016	NN	denotes	mesenchyme
T7389	27016-27018	,	denotes	,
T7390	27018-27021	CC	denotes	and
T7391	27022-27025	DT	denotes	the
T7392	27039-27043	NN	denotes	wall
T7393	27026-27033	JJ	denotes	ventral
T7394	27034-27038	NN	denotes	body
T7395	27044-27045	-LRB-	denotes	(
T7396	27045-27051	NN	denotes	Figure
T7397	27052-27054	CD	denotes	8C
T7398	27054-27055	-RRB-	denotes	)
T7399	27055-27056	.	denotes	.
T7400	27056-27367	sentence	denotes	An adjacent section hybridized with Tbx15 reveals a complementary pattern in the flank, which provides additional evidence for developmental mechanisms that establish a pigmentation boundary entirely within lateral plate mesoderm and independent of lineage restrictions imposed by the lateral somitic frontier.
T7401	27057-27059	DT	denotes	An
T7402	27069-27076	NN	denotes	section
T7403	27060-27068	JJ	denotes	adjacent
T7404	27099-27106	VBZ	denotes	reveals
T7405	27077-27087	VBN	denotes	hybridized
T7406	27088-27092	IN	denotes	with
T7407	27093-27098	NN	denotes	Tbx15
T7408	27107-27108	DT	denotes	a
T7409	27123-27130	NN	denotes	pattern
T7410	27109-27122	JJ	denotes	complementary
T7411	27131-27133	IN	denotes	in
T7412	27134-27137	DT	denotes	the
T7413	27138-27143	NN	denotes	flank
T7414	27143-27145	,	denotes	,
T7415	27145-27150	WDT	denotes	which
T7416	27151-27159	VBZ	denotes	provides
T7417	27160-27170	JJ	denotes	additional
T7418	27171-27179	NN	denotes	evidence
T7419	27180-27183	IN	denotes	for
T7420	27184-27197	JJ	denotes	developmental
T7421	27198-27208	NNS	denotes	mechanisms
T7422	27209-27213	WDT	denotes	that
T7423	27214-27223	VBP	denotes	establish
T7424	27224-27225	DT	denotes	a
T7425	27239-27247	NN	denotes	boundary
T7426	27226-27238	NN	denotes	pigmentation
T7427	27248-27256	RB	denotes	entirely
T7428	27257-27263	IN	denotes	within
T7429	27264-27271	JJ	denotes	lateral
T7430	27272-27277	NN	denotes	plate
T7431	27278-27286	NN	denotes	mesoderm
T7432	27287-27290	CC	denotes	and
T7433	27291-27302	JJ	denotes	independent
T7434	27303-27305	IN	denotes	of
T7435	27306-27313	NN	denotes	lineage
T7436	27314-27326	NNS	denotes	restrictions
T7437	27327-27334	VBN	denotes	imposed
T7438	27335-27337	IN	denotes	by
T7439	27338-27341	DT	denotes	the
T7440	27358-27366	NN	denotes	frontier
T7441	27342-27349	JJ	denotes	lateral
T7442	27350-27357	JJ	denotes	somitic
T7443	27366-27367	.	denotes	.
R1559	T2551	T2549	pobj	Differences,of
R1560	T2552	T2551	compound	Skin,Differences
R1563	T2557	T2554	pobj	change,Besides
R1564	T2558	T2557	amod	obvious,change
R1569	T2563	T2557	relcl	distinguishes,change
R1570	T2564	T2563	advmod	frequently,distinguishes
R1616	T2612	T2601	cc	as,number
R1617	T2613	T2612	advmod	well,as
R1637	T2635	T2637	compound	at,animals
R1638	T2636	T2635	punct	/,at
R1643	T2641	T2639	amod	colored,from
R1644	T2642	T2641	punct	-,colored
R1647	T2645	T2643	amod	yellow,to
R1648	T2646	T2645	punct	-,yellow
R1660	T2658	T2656	pobj	axis,along
R1661	T2659	T2658	amod	dorsoventral,axis
R1678	T2678	T2676	pobj	genotypes,of
R1679	T2679	T2678	compound	Agouti,genotypes
R1694	T2696	T2684	ccomp	coincides,reveal
R1695	T2697	T2698	det	the,boundary
R1696	T2698	T2696	nsubj	boundary,coincides
R1697	T2699	T2698	amod	apparent,boundary
R1698	T2700	T2698	amod	sharp,boundary
R1699	T2701	T2698	prep	between,boundary
R1700	T2702	T2703	amod	dorsal,compartments
R1701	T2703	T2701	pobj	compartments,between
R1702	T2704	T2702	cc	and,dorsal
R1703	T2705	T2702	conj	ventral,dorsal
R1704	T2706	T2703	compound	pigment,compartments
R1705	T2707	T2698	prep	in,boundary
R1706	T2708	T2709	compound	at,at
R1708	T2710	T2709	punct	/,at
R1709	T2711	T2707	pobj	mice,in
R1712	T2714	T2712	pobj	change,with
R1713	T2715	T2716	advmod	more,gradual
R1714	T2716	T2714	amod	gradual,change
R1717	T2719	T2717	pobj	color,in
R1718	T2720	T2719	compound	hair,color
R1723	T2725	T2696	parataxis	1A,coincides
R1724	T2726	T2725	nmod	Figure,1A
R1747	T2751	T2753	compound	at,mice
R1748	T2752	T2751	punct	/,at
R1792	T2799	T2804	advcl	varies,are
R1793	T2800	T2801	compound	hair,cycle
R1795	T2802	T2801	punct	-,cycle
R1796	T2803	T2799	nsubj	timing,varies
R1799	T2807	T2805	pobj	axis,along
R1800	T2808	T2807	amod	rostrocaudal,axis
R1805	T2813	T2811	pobj	length,of
R1806	T2814	T2813	compound	hair,length
R1827	T2837	T2835	pobj	length,of
R1828	T2838	T2837	compound	hair,length
R1859	T2871	T2865	ccomp	stereotyped,indicate
R1860	T2872	T2871	nsubj	variation,stereotyped
R1861	T2873	T2872	prep	of,variation
R1862	T2874	T2875	compound	hair,length
R1863	T2875	T2873	pobj	length,of
R1864	T2876	T2872	prep	along,variation
R1865	T2877	T2878	det	the,axis
R1867	T2879	T2878	amod	dorsoventral,axis
R1868	T2880	T2871	aux	is,stereotyped
R1873	T2885	T2883	pobj	cycles,through
R1874	T2886	T2885	compound	hair,cycles
R1888	T2900	T2898	dobj	transition,encompasses
R1889	T2901	T2902	compound	pigment,type
R1891	T2903	T2902	punct	-,type
R1894	T2906	T2908	compound	at,mice
R1895	T2907	T2906	punct	/,at
R1899	T2912	T2915	nsubj	skin,develop
R1900	T2913	T2911	cc	and,Dorsal
R1901	T2914	T2911	conj	ventral,Dorsal
R1918	T2934	T2923	dobj	follicles,exhibit
R1919	T2935	T2934	compound	hair,follicles
R1923	T2939	T2937	acomp	developed,are
R1924	T2940	T2939	advmod	more,developed
R1927	T2943	T2941	pobj	follicles,than
R1928	T2944	T2943	compound	hair,follicles
R1933	T2949	T2947	pobj	decrease,with
R1934	T2950	T2949	amod	gradual,decrease
R1935	T2951	T2949	amod	dorsoventral,decrease
R1952	T2970	T2972	nummod	4,wk
R1953	T2971	T2970	punct	–,4
R1967	T2985	T2962	conj	is,disappear
R1968	T2986	T2985	punct	", ",is
R1969	T2987	T2988	det	the,proportion
R1970	T2988	T2985	nsubj	proportion,is
R1971	T2989	T2988	prep	of,proportion
R1972	T2990	T2991	amod	different,types
R1974	T2992	T2991	compound	hair,types
R1987	T3007	T3009	amod	matched,mice
R1988	T3008	T3007	punct	-,matched
R1989	T3009	T3004	pobj	mice,In
R1990	T3010	T3009	amod	inbred,mice
R1994	T3014	T3005	dobj	decrease,observed
R1995	T3015	T3014	amod	small,decrease
R2031	T3051	T3049	attr	difference,was
R2032	T3052	T3051	amod	consistent,difference
R2035	T3055	T3057	compound	type,distribution
R2036	T3056	T3055	punct	-,type
R2042	T3062	T3049	parataxis	shown,was
R2043	T3063	T3062	nsubj	data,shown
R2044	T3064	T3062	neg	not,shown
R2050	T3072	T3070	pobj	pigmentation,between
R2051	T3073	T3071	cc	and,dorsal
R2052	T3074	T3071	conj	ventral,dorsal
R2055	T3077	T3079	compound	at,mice
R2056	T3078	T3077	punct	/,at
R2062	T3084	T3086	compound	type,differences
R2063	T3085	T3084	punct	-,type
R2068	T3090	T3092	amod	specific,expression
R2069	T3091	T3090	punct	-,specific
R2076	T3098	T3069	conj	have,attributed
R2077	T3099	T3097	amod	homozygous,animals
R2078	T3100	T3099	prep	for,homozygous
R2079	T3101	T3102	det	a,allele
R2081	T3103	T3102	amod	null,allele
R2082	T3104	T3102	prep	of,allele
R2083	T3105	T3104	pobj	Agouti,of
R2084	T3106	T3102	punct	", ",allele
R2085	T3107	T3108	amod	extreme,nonagouti
R2086	T3108	T3102	appos	nonagouti,allele
R2087	T3109	T3108	punct	(,nonagouti
R2088	T3110	T3108	appos	ae,nonagouti
R2089	T3111	T3108	punct	),nonagouti
R2090	T3112	T3098	punct	", ",have
R2103	T3125	T3123	dobj	appearance,giving
R2104	T3126	T3127	advmod	slightly,paler
R2105	T3127	T3125	amod	paler,appearance
R2108	T3130	T3128	pobj	coat,to
R2109	T3131	T3130	amod	ventral,coat
R2127	T3151	T3139	dobj	transition,observed
R2128	T3152	T3151	amod	gradual,transition
R2129	T3153	T3151	amod	dorsoventral,transition
R2132	T3156	T3154	pobj	preparations,in
R2133	T3157	T3156	compound	dermis,preparations
R2136	T3160	T3158	pobj	mice,from
R2137	T3161	T3162	compound	ae,ae
R2139	T3163	T3162	punct	/,ae
R2151	T3177	T3179	compound	at,mice
R2152	T3178	T3177	punct	/,at
R2155	T3181	T3171	dobj	transition,reveal
R2156	T3182	T3181	amod	abrupt,transition
R2157	T3183	T3181	amod	dorsoventral,transition
R2163	T3189	T3181	relcl	reflects,transition
R2164	T3190	T3189	advmod	probably,reflects
R2166	T3192	T3189	dobj	effects,reflects
R2167	T3193	T3192	amod	additive,effects
R2170	T3196	T3194	pobj	content,of
R2171	T3197	T3196	compound	melanin,content
R2176	T3202	T3204	compound	ae,mice
R2177	T3203	T3202	punct	/,ae
R2196	T3224	T3222	xcomp	influenced,likely
R2197	T3225	T3224	auxpass	be,influenced
R2207	T3235	T3229	conj	environment,number
R2208	T3236	T3235	amod	follicular,environment
R2216	T3246	T3244	pobj	content,in
R2217	T3247	T3246	compound	pigment,content
R2220	T3250	T3252	compound	ae,mice
R2221	T3251	T3250	punct	/,ae
R2225	T3255	T3253	pobj	cycles,throughout
R2226	T3256	T3255	compound	hair,cycles
R2244	T3276	T3278	nummod	three,characteristics
R2245	T3277	T3276	advmod	least,three
R2255	T3287	T3289	compound	type,synthesis
R2256	T3288	T3287	punct	-,type
R2278	T3536	T3535	prep	of,Ventralization
R2279	T3537	T3538	compound	Skin,Morphology
R2280	T3538	T3536	pobj	Morphology,of
R2281	T3539	T3535	prep	by,Ventralization
R2282	T3540	T3541	det	the,Mutation
R2284	T3542	T3543	amod	droopy,ear
R2285	T3543	T3541	compound	ear,Mutation
R2286	T3545	T3546	advcl	Named,is
R2287	T3546	T3556	ccomp	is,is
R2288	T3547	T3545	prep	after,Named
R2289	T3548	T3549	poss	its,effects
R2290	T3549	T3547	pobj	effects,after
R2291	T3550	T3549	prep	on,effects
R2292	T3551	T3552	amod	craniofacial,morphology
R2293	T3552	T3550	pobj	morphology,on
R2294	T3553	T3546	punct	", ",is
R2295	T3554	T3555	amod	droopy,ear
R2296	T3555	T3546	nsubj	ear,is
R2297	T3557	T3558	det	a,mutation
R2298	T3558	T3546	attr	mutation,is
R2299	T3559	T3558	amod	recessive,mutation
R2300	T3560	T3558	prep	on,mutation
R2301	T3561	T3562	compound	mouse,Chromosome
R2302	T3562	T3560	pobj	Chromosome,on
R2303	T3563	T3562	nummod	3,Chromosome
R2304	T3564	T3556	punct	;,is
R2305	T3565	T3566	det	the,allele
R2306	T3566	T3556	nsubj	allele,is
R2307	T3567	T3566	amod	original,allele
R2308	T3568	T3566	acl	described,allele
R2309	T3569	T3570	amod	more,40
R2310	T3570	T3572	nummod	40,years
R2311	T3571	T3570	quantmod	than,40
R2312	T3572	T3573	npadvmod	years,ago
R2313	T3573	T3568	advmod	ago,described
R2314	T3574	T3568	agent	by,described
R2315	T3575	T3574	pobj	Curry,by
R2316	T3576	T3577	punct	(,1959
R2317	T3577	T3568	parataxis	1959,described
R2318	T3578	T3577	punct	),1959
R2319	T3579	T3556	acomp	extinct,is
R2320	T3580	T3556	punct	", ",is
R2321	T3581	T3556	cc	but,is
R2322	T3582	T3583	det	a,remutation
R2323	T3583	T3585	nsubj	remutation,is
R2324	T3584	T3583	amod	spontaneous,remutation
R2325	T3585	T3556	conj	is,is
R2326	T3586	T3587	dep	that,occurred
R2327	T3587	T3583	relcl	occurred,remutation
R2328	T3588	T3587	prep	in,occurred
R2329	T3589	T3588	pobj	Harwell,in
R2330	T3590	T3583	punct	", ",remutation
R2331	T3591	T3583	appos	deH,remutation
R2332	T3592	T3585	punct	", ",is
R2333	T3593	T3585	acomp	available,is
R2334	T3594	T3585	prep	through,is
R2335	T3595	T3596	det	The,Laboratory
R2336	T3596	T3594	pobj	Laboratory,through
R2337	T3597	T3596	compound	Jackson,Laboratory
R2338	T3598	T3599	punct	(,Harbor
R2339	T3599	T3585	parataxis	Harbor,is
R2340	T3600	T3599	compound	Bar,Harbor
R2341	T3601	T3599	punct	", ",Harbor
R2342	T3602	T3599	npadvmod	Maine,Harbor
R2343	T3603	T3599	punct	", ",Harbor
R2344	T3604	T3605	compound	United,States
R2345	T3605	T3599	npadvmod	States,Harbor
R2346	T3606	T3599	punct	),Harbor
R2347	T3607	T3556	punct	.,is
R2348	T3609	T3610	amod	External,malformations
R2349	T3610	T3612	nsubj	malformations,are
R2350	T3611	T3610	amod	craniofacial,malformations
R2351	T3613	T3614	det	the,characteristic
R2353	T3615	T3616	advmod	most,obvious
R2354	T3616	T3614	amod	obvious,characteristic
R2355	T3617	T3614	prep	of,characteristic
R2356	T3618	T3619	compound	deH,deH
R2357	T3619	T3621	compound	deH,animals
R2358	T3620	T3619	punct	/,deH
R2359	T3621	T3617	pobj	animals,of
R2360	T3622	T3612	punct	", ",are
R2361	T3623	T3612	prep	including,are
R2362	T3624	T3625	advmod	widely,spaced
R2363	T3625	T3626	amod	spaced,eyes
R2364	T3626	T3623	pobj	eyes,including
R2365	T3627	T3626	punct	", ",eyes
R2366	T3628	T3629	amod	small,fissures
R2367	T3629	T3626	conj	fissures,eyes
R2368	T3630	T3629	amod	palpebral,fissures
R2369	T3631	T3629	punct	", ",fissures
R2370	T3632	T3633	det	a,area
R2372	T3634	T3633	amod	broad,area
R2373	T3635	T3633	amod	nasal,area
R2374	T3636	T3633	punct	", ",area
R2375	T3637	T3633	cc	and,area
R2376	T3638	T3639	det	a,skull
R2377	T3639	T3633	conj	skull,area
R2378	T3640	T3639	amod	shortened,skull
R2379	T3641	T3639	acl	held,skull
R2380	T3642	T3641	prep	in,held
R2381	T3643	T3644	det	an,position
R2382	T3644	T3642	pobj	position,in
R2383	T3645	T3644	amod	elevated,position
R2384	T3646	T3639	punct	", ",skull
R2385	T3647	T3648	dep	which,causes
R2386	T3648	T3639	relcl	causes,skull
R2387	T3649	T3648	advmod	presumably,causes
R2388	T3650	T3648	cc	or,causes
R2389	T3651	T3648	conj	contributes,causes
R2390	T3652	T3651	prep	to,contributes
R2391	T3653	T3654	det	the,position
R2392	T3654	T3651	dobj	position,contributes
R2393	T3655	T3654	amod	abnormal,position
R2394	T3656	T3654	prep	of,position
R2395	T3657	T3658	det	the,ears
R2396	T3658	T3656	pobj	ears,of
R2397	T3659	T3612	punct	.,are
R2398	T3661	T3662	nsubj	We,became
R2399	T3662	T3663	ccomp	became,comes
R2400	T3664	T3662	acomp	interested,became
R2401	T3665	T3664	prep	in,interested
R2402	T3666	T3667	amod	droopy,ear
R2403	T3667	T3665	pobj	ear,in
R2404	T3668	T3669	mark	because,described
R2405	T3669	T3662	advcl	described,became
R2406	T3670	T3671	det	the,allele
R2407	T3671	T3669	nsubjpass	allele,described
R2408	T3672	T3671	amod	original,allele
R2409	T3673	T3669	auxpass	was,described
R2410	T3674	T3675	aux	to,affect
R2411	T3675	T3669	xcomp	affect,described
R2412	T3676	T3677	compound	pigment,pattern
R2413	T3677	T3675	dobj	pattern,affect
R2414	T3678	T3675	prep	in,affect
R2415	T3679	T3680	det	a,way
R2416	T3680	T3678	pobj	way,in
R2417	T3681	T3682	dep	that,suggests
R2418	T3682	T3680	relcl	suggests,way
R2419	T3683	T3684	det	a,transformation
R2420	T3684	T3682	dobj	transformation,suggests
R2421	T3685	T3684	amod	possible,transformation
R2422	T3686	T3684	amod	dorsal,transformation
R2423	T3687	T3686	prep	to,dorsal
R2424	T3688	T3687	amod	ventral,to
R2425	T3689	T3663	punct	: ,comes
R2426	T3690	T3663	punct	“,comes
R2427	T3691	T3663	prep	On,comes
R2428	T3692	T3693	det	a,background
R2429	T3693	T3691	pobj	background,On
R2430	T3694	T3693	amod	genetic,background
R2431	T3695	T3693	punct	(,background
R2432	T3696	T3693	appos	at,background
R2433	T3697	T3696	cc	and,at
R2434	T3698	T3696	conj	AW,at
R2435	T3699	T3693	punct	),background
R2436	T3700	T3701	dep	which,causes
R2437	T3701	T3693	relcl	causes,background
R2438	T3702	T3703	det	the,hair
R2439	T3703	T3705	nsubj	hair,be
R2440	T3704	T3703	compound	belly,hair
R2441	T3705	T3701	ccomp	be,causes
R2442	T3706	T3705	aux	to,be
R2443	T3707	T3705	acomp	lighter,be
R2444	T3708	T3707	prep	than,lighter
R2445	T3709	T3710	det	the,hair
R2446	T3710	T3708	pobj	hair,than
R2447	T3711	T3710	compound	back,hair
R2448	T3712	T3663	punct	", ",comes
R2449	T3713	T3714	det	the,hair
R2450	T3714	T3663	nsubj	hair,comes
R2451	T3715	T3714	compound	belly,hair
R2452	T3716	T3663	prt	up,comes
R2453	T3717	T3663	advmod	farther,comes
R2454	T3718	T3663	prep	round,comes
R2455	T3719	T3720	det	the,sides
R2456	T3720	T3718	pobj	sides,round
R2457	T3721	T3720	prep	of,sides
R2458	T3722	T3723	det	the,body
R2459	T3723	T3721	pobj	body,of
R2460	T3724	T3723	cc	and,body
R2461	T3725	T3723	conj	face,body
R2462	T3726	T3663	punct	”,comes
R2463	T3727	T3728	punct	(,Curry
R2464	T3728	T3663	meta	Curry,comes
R2465	T3729	T3728	nummod	1959,Curry
R2466	T3730	T3728	punct	),Curry
R2467	T3731	T3663	punct	.,comes
R2468	T3733	T3734	det	An,pattern
R2469	T3734	T3738	nsubj	pattern,is
R2470	T3735	T3734	amod	abnormal,pattern
R2471	T3736	T3734	amod	dorsoventral,pattern
R2472	T3737	T3734	compound	pigment,pattern
R2473	T3739	T3740	advmod	readily,apparent
R2474	T3740	T3738	acomp	apparent,is
R2475	T3741	T3738	prep	in,is
R2476	T3742	T3743	nmod	at,at
R2477	T3743	T3745	nmod	at,mice
R2478	T3744	T3743	punct	/,at
R2479	T3745	T3741	pobj	mice,in
R2480	T3746	T3743	punct	;,at
R2481	T3747	T3748	compound	deH,deH
R2482	T3748	T3743	appos	deH,at
R2483	T3749	T3748	punct	/,deH
R2484	T3750	T3738	punct	", ",is
R2485	T3751	T3738	cc	but,is
R2486	T3752	T3753	nsubjpass	comparison,described
R2487	T3753	T3738	conj	described,is
R2488	T3754	T3752	prep	to,comparison
R2489	T3755	T3756	amod	nonmutant,animals
R2490	T3756	T3754	pobj	animals,to
R2491	T3757	T3753	auxpass	is,described
R2492	T3758	T3759	advmod	more,accurately
R2493	T3759	T3753	advmod	accurately,described
R2494	T3760	T3753	prep	in,described
R2495	T3761	T3760	pobj	terms,in
R2496	T3762	T3761	prep	of,terms
R2497	T3763	T3764	amod	ventral,regions
R2498	T3764	T3762	pobj	regions,of
R2499	T3765	T3763	punct	", ",ventral
R2500	T3766	T3763	conj	lateral,ventral
R2501	T3767	T3766	punct	", ",lateral
R2502	T3768	T3766	cc	and,lateral
R2503	T3769	T3766	conj	dorsal,lateral
R2504	T3770	T3771	punct	(,1G
R2505	T3771	T3753	parataxis	1G,described
R2506	T3772	T3771	nmod	Figures,1G
R2507	T3773	T3771	cc	and,1G
R2508	T3774	T3771	conj	2A,1G
R2509	T3775	T3771	punct	),1G
R2510	T3776	T3753	punct	.,described
R2511	T3778	T3779	det	The,region
R2512	T3779	T3781	nsubj	region,has
R2513	T3780	T3779	amod	ventral,region
R2514	T3781	T3782	ccomp	has,are
R2515	T3783	T3784	amod	short,hairs
R2516	T3784	T3781	dobj	hairs,has
R2517	T3785	T3784	prep	with,hairs
R2518	T3786	T3787	det	a,base
R2519	T3787	T3785	pobj	base,with
R2520	T3788	T3787	amod	gray,base
R2521	T3789	T3787	cc	and,base
R2522	T3790	T3791	npadvmod	cream,colored
R2523	T3791	T3793	amod	colored,tip
R2524	T3792	T3791	punct	-,colored
R2525	T3793	T3787	conj	tip,base
R2526	T3794	T3795	poss	whose,boundary
R2527	T3795	T3796	dep	boundary,coincides
R2528	T3796	T3784	relcl	coincides,hairs
R2529	T3797	T3796	prep	with,coincides
R2530	T3798	T3799	det	the,junction
R2531	T3799	T3797	pobj	junction,with
R2532	T3800	T3801	compound	limb,body
R2533	T3801	T3799	compound	body,junction
R2534	T3802	T3801	punct	–,body
R2535	T3803	T3799	compound	wall,junction
R2536	T3804	T3782	punct	;,are
R2537	T3805	T3806	preconj	both,appearance
R2538	T3806	T3782	nsubj	appearance,are
R2539	T3807	T3806	det	the,appearance
R2540	T3808	T3806	prep	of,appearance
R2541	T3809	T3810	det	this,region
R2542	T3810	T3808	pobj	region,of
R2543	T3811	T3806	cc	and,appearance
R2544	T3812	T3806	conj	position,appearance
R2545	T3813	T3812	prep	of,position
R2546	T3814	T3815	det	the,boundary
R2547	T3815	T3813	pobj	boundary,of
R2548	T3816	T3817	advmod	approximately,similar
R2549	T3817	T3782	acomp	similar,are
R2550	T3818	T3782	prep	in,are
R2551	T3819	T3820	nmod	at,at
R2552	T3820	T3822	nmod	at,mice
R2553	T3821	T3820	punct	/,at
R2554	T3822	T3818	pobj	mice,in
R2555	T3823	T3820	prep	compared,at
R2556	T3824	T3823	prep	to,compared
R2557	T3825	T3826	compound	at,at
R2558	T3826	T3824	pobj	at,to
R2559	T3827	T3826	punct	/,at
R2560	T3828	T3826	punct	;,at
R2561	T3829	T3830	compound	deH,deH
R2562	T3830	T3826	appos	deH,at
R2563	T3831	T3830	punct	/,deH
R2564	T3832	T3782	punct	.,are
R2565	T3834	T3835	det	The,region
R2566	T3835	T3837	nsubj	region,contains
R2567	T3836	T3835	amod	lateral,region
R2568	T3837	T3838	ccomp	contains,appears
R2569	T3839	T3840	amod	yellow,hairs
R2570	T3840	T3837	dobj	hairs,contains
R2571	T3841	T3840	prep	of,hairs
R2572	T3842	T3843	advmod	progressively,increasing
R2573	T3843	T3844	amod	increasing,length
R2574	T3844	T3841	pobj	length,of
R2575	T3845	T3838	punct	;,appears
R2576	T3846	T3838	prep	in,appears
R2577	T3847	T3848	compound	at,at
R2578	T3848	T3850	compound	at,mice
R2579	T3849	T3848	punct	/,at
R2580	T3850	T3846	pobj	mice,in
R2581	T3851	T3838	punct	", ",appears
R2582	T3852	T3853	det	the,region
R2583	T3853	T3838	nsubj	region,appears
R2584	T3854	T3853	amod	lateral,region
R2585	T3855	T3838	prep	as,appears
R2586	T3856	T3857	det	a,stripe
R2588	T3858	T3857	amod	thin,stripe
R2589	T3859	T3857	amod	yellow,stripe
R2590	T3860	T3838	prep	along,appears
R2591	T3861	T3862	det	the,flank
R2592	T3862	T3860	pobj	flank,along
R2593	T3863	T3838	punct	", ",appears
R2594	T3864	T3838	cc	but,appears
R2595	T3865	T3866	prep	in,is
R2596	T3866	T3838	conj	is,appears
R2597	T3867	T3868	nmod	at,at
R2598	T3868	T3870	nmod	at,mice
R2599	T3869	T3868	punct	/,at
R2600	T3870	T3865	pobj	mice,in
R2601	T3871	T3868	punct	;,at
R2602	T3872	T3873	compound	deH,deH
R2603	T3873	T3868	appos	deH,at
R2604	T3874	T3873	punct	/,deH
R2605	T3875	T3866	punct	", ",is
R2606	T3876	T3877	det	the,region
R2607	T3877	T3866	nsubj	region,is
R2608	T3878	T3877	amod	lateral,region
R2609	T3879	T3880	advmod	considerably,expanded
R2610	T3880	T3866	acomp	expanded,is
R2611	T3881	T3866	prep	with,is
R2612	T3882	T3883	det	a,boundary
R2613	T3883	T3881	pobj	boundary,with
R2614	T3884	T3883	amod	diffuse,boundary
R2615	T3885	T3883	prep	along,boundary
R2616	T3886	T3887	det	the,flank
R2617	T3887	T3885	pobj	flank,along
R2618	T3888	T3887	amod	dorsal,flank
R2619	T3889	T3883	punct	", ",boundary
R2620	T3890	T3883	cc	and,boundary
R2621	T3891	T3892	det	a,region
R2623	T3893	T3892	amod	dorsal,region
R2624	T3894	T3892	amod	eumelanic,region
R2625	T3895	T3896	poss	whose,size
R2626	T3896	T3897	dep	size,reduced
R2628	T3898	T3897	auxpass	is,reduced
R2629	T3899	T3897	advmod	correspondingly,reduced
R2630	T3900	T3901	punct	(,2A
R2631	T3901	T3866	parataxis	2A,is
R2632	T3902	T3901	nmod	Figure,2A
R2633	T3903	T3901	cc	and,2A
R2634	T3904	T3901	conj	2B,2A
R2635	T3905	T3901	punct	),2A
R2636	T3906	T3838	punct	.,appears
R2637	T3908	T3909	amod	Total,size
R2638	T3909	T3911	nsubj	size,is
R2639	T3910	T3909	compound	body,size
R2640	T3912	T3911	acomp	smaller,is
R2641	T3913	T3911	prep	in,is
R2642	T3914	T3913	pobj	mutant,in
R2643	T3915	T3914	prep	compared,mutant
R2644	T3916	T3915	prep	to,compared
R2645	T3917	T3916	pobj	nonmutant,to
R2646	T3918	T3914	appos	animals,mutant
R2647	T3919	T3911	punct	", ",is
R2648	T3920	T3911	cc	but,is
R2649	T3921	T3922	det	the,proportion
R2650	T3922	T3923	nsubjpass	proportion,increased
R2651	T3923	T3911	conj	increased,is
R2652	T3924	T3922	prep	of,proportion
R2653	T3925	T3926	compound	body,circumference
R2654	T3926	T3924	pobj	circumference,of
R2655	T3927	T3922	acl	occupied,proportion
R2656	T3928	T3927	agent	by,occupied
R2657	T3929	T3930	det	the,region
R2658	T3930	T3928	pobj	region,by
R2659	T3931	T3930	amod	lateral,region
R2660	T3932	T3927	prep	in,occupied
R2661	T3933	T3934	amod	mutant,animals
R2662	T3934	T3932	pobj	animals,in
R2663	T3935	T3923	auxpass	is,increased
R2664	T3936	T3937	advmod	about,2
R2665	T3937	T3938	quantmod	2,fold
R2666	T3938	T3923	advmod	fold,increased
R2667	T3939	T3938	punct	-,fold
R2668	T3940	T3923	punct	", ",increased
R2669	T3941	T3923	prep	from,increased
R2670	T3942	T3943	nummod	11.9,%
R2671	T3943	T3941	pobj	%,from
R2672	T3944	T3923	prep	to,increased
R2673	T3945	T3946	nummod	22.2,%
R2674	T3946	T3944	pobj	%,to
R2675	T3947	T3948	punct	(,Figure
R2676	T3948	T3923	parataxis	Figure,increased
R2677	T3949	T3948	nummod	2C,Figure
R2678	T3950	T3948	punct	),Figure
R2679	T3951	T3923	punct	.,increased
R2680	T3953	T3954	det	The,proportion
R2681	T3954	T3955	nsubjpass	proportion,expanded
R2682	T3956	T3954	prep	of,proportion
R2683	T3957	T3958	det	the,region
R2684	T3958	T3956	pobj	region,of
R2685	T3959	T3958	amod	ventral,region
R2686	T3960	T3961	npadvmod	cream,colored
R2687	T3961	T3958	amod	colored,region
R2688	T3962	T3961	punct	-,colored
R2689	T3963	T3955	auxpass	is,expanded
R2690	T3964	T3955	advmod	also,expanded
R2691	T3965	T3966	det	a,amount
R2692	T3966	T3955	npadvmod	amount,expanded
R2693	T3967	T3966	amod	small,amount
R2694	T3968	T3966	punct	", ",amount
R2695	T3969	T3970	nummod	47.9,%
R2696	T3970	T3966	appos	%,amount
R2697	T3971	T3955	prep	in,expanded
R2698	T3972	T3971	pobj	mutant,in
R2699	T3973	T3955	prep	compared,expanded
R2700	T3974	T3973	prep	to,compared
R2701	T3975	T3976	nummod	37.8,%
R2702	T3976	T3974	pobj	%,to
R2703	T3977	T3976	prep	in,%
R2704	T3978	T3977	pobj	nonmutant,in
R2705	T3979	T3955	dobj	animals,expanded
R2706	T3980	T3955	punct	", ",expanded
R2707	T3981	T3955	cc	but,expanded
R2708	T3982	T3983	nsubj	expansion,is
R2709	T3983	T3955	conj	is,expanded
R2710	T3984	T3982	prep	of,expansion
R2711	T3985	T3986	det	the,region
R2712	T3986	T3984	pobj	region,of
R2713	T3987	T3986	amod	lateral,region
R2714	T3988	T3982	punct	", ",expansion
R2715	T3989	T3990	dep	which,occurs
R2716	T3990	T3982	relcl	occurs,expansion
R2717	T3991	T3990	prep	at,occurs
R2718	T3992	T3993	det	all,levels
R2719	T3993	T3991	pobj	levels,at
R2720	T3994	T3993	prep	of,levels
R2721	T3995	T3996	det	the,body
R2722	T3996	T3994	pobj	body,of
R2723	T3997	T3993	punct	", ",levels
R2724	T3998	T3993	prep	including,levels
R2725	T3999	T4000	det	the,limbs
R2726	T4000	T3998	pobj	limbs,including
R2727	T4001	T4000	cc	and,limbs
R2728	T4002	T4003	det	the,cranium
R2729	T4003	T4000	conj	cranium,limbs
R2730	T4004	T4000	punct	(,limbs
R2731	T4005	T4000	cc	but,limbs
R2732	T4006	T4005	neg	not,but
R2733	T4007	T4008	det	the,pad
R2734	T4008	T4000	conj	pad,limbs
R2735	T4009	T4008	compound	whisker,pad
R2736	T4010	T4008	punct	),pad
R2737	T4011	T3983	punct	", ",is
R2738	T4012	T4013	det	the,feature
R2739	T4013	T3983	attr	feature,is
R2740	T4014	T4013	amod	major,feature
R2741	T4015	T4013	amod	responsible,feature
R2742	T4016	T4015	prep	for,responsible
R2743	T4017	T4018	det	the,appearance
R2744	T4018	T4016	pobj	appearance,for
R2745	T4019	T4018	amod	ventralized,appearance
R2746	T4020	T4018	acl	caused,appearance
R2747	T4021	T4020	agent	by,caused
R2748	T4022	T4021	pobj	deH,by
R2749	T4023	T3983	punct	.,is
R2750	T4025	T4026	aux	To,investigate
R2751	T4026	T4027	advcl	investigate,examined
R2752	T4028	T4029	mark	whether,affects
R2753	T4029	T4026	ccomp	affects,investigate
R2754	T4030	T4029	nsubj	deH,affects
R2755	T4031	T4032	amod	other,characteristics
R2757	T4033	T4032	amod	dorsoventral,characteristics
R2758	T4034	T4032	compound	skin,characteristics
R2759	T4035	T4032	prep	besides,characteristics
R2760	T4036	T4037	compound	pigment,type
R2761	T4037	T4035	pobj	type,besides
R2762	T4038	T4037	punct	-,type
R2763	T4039	T4037	amod	switching,type
R2764	T4040	T4027	punct	", ",examined
R2765	T4041	T4027	nsubj	we,examined
R2766	T4042	T4043	poss	its,effects
R2767	T4043	T4027	dobj	effects,examined
R2768	T4044	T4043	prep	on,effects
R2769	T4045	T4046	compound	hair,length
R2770	T4046	T4044	pobj	length,on
R2771	T4047	T4046	cc	and,length
R2772	T4048	T4046	conj	pigmentation,length
R2773	T4049	T4027	prep	in,examined
R2774	T4050	T4051	det	an,background
R2775	T4051	T4049	pobj	background,in
R2776	T4052	T4053	compound	ae,ae
R2777	T4053	T4051	compound	ae,background
R2778	T4054	T4053	punct	/,ae
R2779	T4055	T4027	punct	.,examined
R2780	T4057	T4058	advmod	Overall,causes
R2782	T4059	T4058	punct	", ",causes
R2783	T4060	T4058	nsubj	deH,causes
R2784	T4062	T4063	det	a,reduction
R2785	T4063	T4058	dobj	reduction,causes
R2786	T4064	T4063	amod	small,reduction
R2787	T4065	T4064	cc	but,small
R2788	T4066	T4064	conj	consistent,small
R2789	T4067	T4063	prep	in,reduction
R2790	T4068	T4069	compound	hair,length
R2791	T4069	T4067	pobj	length,in
R2792	T4070	T4058	prep	in,causes
R2793	T4071	T4072	preconj	both,dorsum
R2794	T4072	T4070	pobj	dorsum,in
R2795	T4073	T4072	cc	and,dorsum
R2796	T4074	T4072	conj	ventrum,dorsum
R2797	T4075	T4061	punct	;,is
R2798	T4076	T4077	advmod	when,normalized
R2799	T4077	T4061	advcl	normalized,is
R2800	T4078	T4079	amod	mutant,animals
R2801	T4079	T4077	nsubjpass	animals,normalized
R2802	T4080	T4078	cc	and,mutant
R2803	T4081	T4078	conj	nonmutant,mutant
R2804	T4082	T4077	auxpass	are,normalized
R2805	T4083	T4077	prep	for,normalized
R2806	T4084	T4085	compound	body,circumference
R2807	T4085	T4083	pobj	circumference,for
R2808	T4086	T4061	punct	", ",is
R2809	T4087	T4088	amod	reduced,length
R2810	T4088	T4061	nsubj	length,is
R2811	T4089	T4088	compound	hair,length
R2812	T4090	T4091	advmod	most,apparent
R2813	T4091	T4061	acomp	apparent,is
R2814	T4092	T4061	prep	in,is
R2815	T4093	T4094	det	the,region
R2816	T4094	T4092	pobj	region,in
R2817	T4095	T4094	amod	lateral,region
R2818	T4096	T4097	punct	(,Figure
R2819	T4097	T4061	parataxis	Figure,is
R2820	T4098	T4097	nummod	2E,Figure
R2821	T4099	T4097	punct	),Figure
R2822	T4100	T4061	punct	.,is
R2823	T4102	T4103	amod	Adult,animals
R2824	T4103	T4111	nsubj	animals,exhibit
R2825	T4104	T4105	nmod	ae,ae
R2826	T4105	T4103	nmod	ae,animals
R2827	T4106	T4105	punct	/,ae
R2828	T4107	T4105	punct	;,ae
R2829	T4108	T4109	compound	deH,deH
R2830	T4109	T4105	appos	deH,ae
R2831	T4110	T4109	punct	/,deH
R2832	T4112	T4113	compound	body,size
R2833	T4113	T4115	compound	size,reduction
R2834	T4114	T4113	punct	-,size
R2835	T4115	T4111	dobj	reduction,exhibit
R2836	T4116	T4115	cc	and,reduction
R2837	T4117	T4118	amod	skeletal,abnormalities
R2838	T4118	T4115	conj	abnormalities,reduction
R2839	T4119	T4111	punct	", ",exhibit
R2840	T4120	T4111	cc	but,exhibit
R2841	T4121	T4111	conj	display,exhibit
R2842	T4122	T4123	det	no,phenotype
R2843	T4123	T4121	dobj	phenotype,display
R2844	T4124	T4125	compound	coat,color
R2845	T4125	T4123	compound	color,phenotype
R2846	T4126	T4125	punct	-,color
R2847	T4127	T4128	punct	(,shown
R2849	T4129	T4128	nsubj	data,shown
R2850	T4130	T4128	neg	not,shown
R2851	T4131	T4128	punct	),shown
R2852	T4132	T4111	punct	.,exhibit
R2853	T4134	T4135	advmod	However,are
R2854	T4136	T4135	punct	", ",are
R2855	T4137	T4138	nmod	ae,ae
R2856	T4138	T4140	nmod	ae,neonates
R2857	T4139	T4138	punct	/,ae
R2858	T4140	T4135	nsubj	neonates,are
R2859	T4141	T4138	cc	and,ae
R2860	T4142	T4143	nmod	ae,ae
R2861	T4143	T4138	conj	ae,ae
R2862	T4144	T4143	punct	/,ae
R2863	T4145	T4143	punct	;,ae
R2864	T4146	T4147	compound	deH,deH
R2865	T4147	T4143	appos	deH,ae
R2866	T4148	T4147	punct	/,deH
R2867	T4149	T4135	advmod	clearly,are
R2868	T4150	T4135	acomp	distinguishable,are
R2869	T4151	T4135	prep	in,are
R2870	T4152	T4153	det	the,days
R2872	T4154	T4153	amod	first,days
R2873	T4155	T4153	amod	few,days
R2874	T4156	T4153	prep	after,days
R2875	T4157	T4156	pobj	birth,after
R2876	T4158	T4135	punct	", ",are
R2877	T4159	T4160	advmod	when,is
R2878	T4160	T4135	advcl	is,are
R2879	T4161	T4162	det	a,gradient
R2880	T4162	T4160	nsubj	gradient,is
R2881	T4163	T4162	amod	dorsoventral,gradient
R2882	T4164	T4162	prep	of,gradient
R2883	T4165	T4166	amod	melanogenic,activity
R2884	T4166	T4164	pobj	activity,of
R2885	T4167	T4160	acomp	apparent,is
R2886	T4168	T4160	prep	under,is
R2887	T4169	T4170	det	the,skin
R2888	T4170	T4168	pobj	skin,under
R2889	T4171	T4172	punct	(,Figure
R2890	T4172	T4135	parataxis	Figure,are
R2891	T4173	T4172	nummod	2D,Figure
R2892	T4174	T4172	punct	),Figure
R2893	T4175	T4135	punct	.,are
R2894	T4177	T4178	prep	At,is
R2895	T4179	T4180	det	this,stage
R2896	T4180	T4177	pobj	stage,At
R2897	T4181	T4178	punct	", ",is
R2898	T4182	T4183	compound	melanoblast,migration
R2899	T4183	T4178	nsubj	migration,is
R2900	T4184	T4183	prep	from,migration
R2901	T4185	T4186	det	the,crest
R2902	T4186	T4184	pobj	crest,from
R2903	T4187	T4186	amod	neural,crest
R2904	T4188	T4189	advmod	mostly,complete
R2905	T4189	T4178	acomp	complete,is
R2906	T4190	T4178	punct	", ",is
R2907	T4191	T4178	cc	but,is
R2908	T4192	T4193	expl	there,is
R2909	T4193	T4178	conj	is,is
R2910	T4194	T4195	det	a,gradient
R2911	T4195	T4193	attr	gradient,is
R2912	T4196	T4195	amod	dorsoventral,gradient
R2913	T4197	T4195	prep	in,gradient
R2914	T4198	T4199	compound	melanocyte,differentiation
R2915	T4199	T4197	pobj	differentiation,in
R2916	T4200	T4199	cc	and,differentiation
R2917	T4201	T4202	compound	pigment,synthesis
R2918	T4202	T4199	conj	synthesis,differentiation
R2919	T4203	T4178	punct	.,is
R2920	T4205	T4206	det	The,skin
R2921	T4206	T4207	nsubj	skin,appears
R2922	T4208	T4206	prep	of,skin
R2923	T4209	T4210	compound	ae,ae
R2924	T4210	T4212	compound	ae,neonates
R2925	T4211	T4210	punct	/,ae
R2926	T4212	T4208	pobj	neonates,of
R2927	T4213	T4214	advmod	uniformly,dark
R2928	T4214	T4207	oprd	dark,appears
R2929	T4215	T4207	prep	over,appears
R2930	T4216	T4217	det	the,dorsum
R2931	T4217	T4215	pobj	dorsum,over
R2932	T4218	T4217	amod	entire,dorsum
R2933	T4219	T4207	punct	", ",appears
R2934	T4220	T4207	cc	but,appears
R2935	T4221	T4222	prep	in,is
R2936	T4222	T4207	conj	is,appears
R2937	T4223	T4224	nmod	ae,ae
R2938	T4224	T4226	nmod	ae,neonates
R2939	T4225	T4224	punct	/,ae
R2940	T4226	T4221	pobj	neonates,in
R2941	T4227	T4224	punct	;,ae
R2942	T4228	T4229	compound	deH,deH
R2943	T4229	T4224	appos	deH,ae
R2944	T4230	T4229	punct	/,deH
R2945	T4231	T4222	punct	", ",is
R2946	T4232	T4233	det	the,area
R2947	T4233	T4222	nsubj	area,is
R2948	T4234	T4233	prep	of,area
R2949	T4235	T4236	amod	dark,skin
R2950	T4236	T4234	pobj	skin,of
R2951	T4237	T4238	advmod	more,restricted
R2952	T4238	T4222	acomp	restricted,is
R2953	T4239	T4222	punct	", ",is
R2954	T4240	T4241	advmod	particularly,above
R2955	T4241	T4222	prep	above,is
R2956	T4242	T4243	det	the,limbs
R2957	T4243	T4241	pobj	limbs,above
R2958	T4244	T4222	punct	", ",is
R2959	T4245	T4222	cc	and,is
R2960	T4246	T4222	conj	resembles,is
R2961	T4247	T4248	det	the,pattern
R2962	T4248	T4246	dobj	pattern,resembles
R2963	T4249	T4248	prep	of,pattern
R2964	T4250	T4251	amod	dorsal,eumelanin
R2965	T4251	T4249	pobj	eumelanin,of
R2966	T4252	T4248	prep	in,pattern
R2967	T4253	T4254	nmod	at,at
R2968	T4254	T4256	nmod	at,animals
R2969	T4255	T4254	punct	/,at
R2970	T4256	T4252	pobj	animals,in
R2971	T4257	T4254	punct	;,at
R2972	T4258	T4259	compound	deH,deH
R2973	T4259	T4254	appos	deH,at
R2974	T4260	T4259	punct	/,deH
R2975	T4261	T4256	amod	adult,animals
R2976	T4262	T4222	punct	.,is
R2977	T4264	T4265	advcl	Taken,suggest
R2978	T4266	T4264	advmod	together,Taken
R2979	T4267	T4265	punct	", ",suggest
R2980	T4268	T4269	det	these,observations
R2981	T4269	T4265	nsubj	observations,suggest
R2982	T4270	T4271	mark	that,interferes
R2983	T4271	T4265	ccomp	interferes,suggest
R2984	T4272	T4271	nsubj	deH,interferes
R2985	T4273	T4271	prep	with,interferes
R2986	T4274	T4275	det	the,establishment
R2987	T4275	T4273	pobj	establishment,with
R2988	T4276	T4275	prep	of,establishment
R2989	T4277	T4278	amod	dorsoventral,patterning
R2990	T4278	T4276	pobj	patterning,of
R2991	T4279	T4271	prep	during,interferes
R2992	T4280	T4281	compound	skin,development
R2993	T4281	T4279	pobj	development,during
R2994	T4282	T4271	prep	by,interferes
R2995	T4283	T4282	pcomp	causing,by
R2996	T4284	T4285	amod	dorsal,expansion
R2997	T4285	T4283	dobj	expansion,causing
R2998	T4286	T4285	prep	of,expansion
R2999	T4287	T4288	det	a,region
R3000	T4288	T4286	pobj	region,of
R3001	T4289	T4288	amod	lateral,region
R3002	T4290	T4291	dep	that,is
R3003	T4291	T4288	relcl	is,region
R3004	T4292	T4291	advmod	normally,is
R3005	T4293	T4294	quantmod	3,5
R3006	T4294	T4296	nummod	5,mm
R3007	T4295	T4294	punct	–,5
R3008	T4296	T4291	attr	mm,is
R3009	T4297	T4296	prep	in,mm
R3010	T4298	T4297	pobj	width,in
R3011	T4299	T4265	punct	.,suggest
R3012	T4301	T4302	det	This,region
R3013	T4302	T4304	nsubj	region,serve
R3014	T4303	T4302	amod	same,region
R3015	T4305	T4304	aux	may,serve
R3016	T4306	T4304	prep	as,serve
R3017	T4307	T4308	det	a,boundary
R3018	T4308	T4306	pobj	boundary,as
R3019	T4309	T4308	prep	between,boundary
R3020	T4310	T4311	amod	dorsal,skin
R3022	T4312	T4310	cc	and,dorsal
R3023	T4313	T4310	conj	ventral,dorsal
R3024	T4314	T4304	prep	by,serve
R3025	T4315	T4314	pcomp	inhibiting,by
R3026	T4316	T4317	compound	melanocyte,differentiation
R3027	T4317	T4315	dobj	differentiation,inhibiting
R3028	T4318	T4314	punct	", ",by
R3029	T4319	T4314	conj	by,by
R3030	T4320	T4319	pcomp	promoting,by
R3031	T4321	T4322	compound	pheomelanin,synthesis
R3032	T4322	T4320	dobj	synthesis,promoting
R3033	T4323	T4319	punct	", ",by
R3034	T4324	T4319	cc	and,by
R3035	T4325	T4319	conj	by,by
R3036	T4326	T4325	pcomp	supporting,by
R3037	T4327	T4328	det	a,increase
R3038	T4328	T4326	dobj	increase,supporting
R3039	T4329	T4328	amod	progressive,increase
R3040	T4330	T4328	prep	in,increase
R3041	T4331	T4332	compound	hair,growth
R3042	T4332	T4330	pobj	growth,in
R3043	T4333	T4328	prep	from,increase
R3044	T4334	T4333	pobj	ventrum,from
R3045	T4335	T4328	prep	to,increase
R3046	T4336	T4335	pobj	dorsum,to
R3047	T4337	T4304	punct	.,serve
R3048	T4339	T4340	mark	As,described
R3049	T4340	T4341	advcl	described,expressed
R3050	T4342	T4340	advmod	below,described
R3051	T4343	T4341	punct	", ",expressed
R3052	T4344	T4345	det	the,gene
R3053	T4345	T4341	nsubjpass	gene,expressed
R3054	T4346	T4345	amod	defective,gene
R3055	T4347	T4346	prep	in,defective
R3056	T4348	T4347	pobj	deH,in
R3057	T4349	T4345	punct	", ",gene
R3058	T4350	T4345	appos	Tbx15,gene
R3059	T4351	T4341	punct	", ",expressed
R3060	T4352	T4341	auxpass	is,expressed
R3061	T4353	T4341	advmod	normally,expressed
R3062	T4354	T4341	prep	in,expressed
R3063	T4355	T4356	det	the,region
R3064	T4356	T4354	pobj	region,in
R3065	T4357	T4356	amod	dorsal,region
R3066	T4358	T4341	cc	and,expressed
R3067	T4359	T4360	advmod	therefore,is
R3068	T4360	T4341	conj	is,expressed
R3069	T4361	T4360	acomp	likely,is
R3070	T4362	T4363	aux	to,play
R3071	T4363	T4361	xcomp	play,likely
R3072	T4364	T4365	det	a,role
R3073	T4365	T4363	dobj	role,play
R3074	T4366	T4363	prep	in,play
R3075	T4367	T4366	pcomp	establishing,in
R3076	T4368	T4369	det	the,size
R3077	T4369	T4367	dobj	size,establishing
R3078	T4370	T4369	cc	and,size
R3079	T4371	T4372	amod	dorsal,extent
R3080	T4372	T4369	conj	extent,size
R3081	T4373	T4369	prep	of,size
R3082	T4374	T4375	det	the,region
R3083	T4375	T4373	pobj	region,of
R3084	T4376	T4375	amod	lateral,region
R3085	T4377	T4341	punct	.,expressed
R3088	T4613	T4614	amod	Positional,Cloning
R3089	T4615	T4614	prep	of,Cloning
R3090	T4616	T4615	pobj	deH,of
R3091	T4618	T4619	prep	As,identified
R3092	T4620	T4621	det	a,marker
R3093	T4621	T4618	pobj	marker,As
R3094	T4622	T4621	amod	visible,marker
R3095	T4623	T4619	punct	", ",identified
R3096	T4624	T4625	amod	early,studies
R3097	T4625	T4619	nsubj	studies,identified
R3098	T4626	T4625	compound	linkage,studies
R3099	T4627	T4625	prep	with,studies
R3100	T4628	T4629	det	the,allele
R3101	T4629	T4627	pobj	allele,with
R3102	T4630	T4629	amod	original,allele
R3103	T4631	T4632	amod	droopy,ear
R3104	T4632	T4629	compound	ear,allele
R3105	T4633	T4629	cc	or,allele
R3106	T4634	T4635	det	the,allele
R3107	T4635	T4629	conj	allele,allele
R3108	T4636	T4635	compound	deH,allele
R3109	T4637	T4638	det	a,position
R3110	T4638	T4619	dobj	position,identified
R3111	T4639	T4638	compound	map,position
R3112	T4640	T4638	prep	in,position
R3113	T4641	T4642	det	the,middle
R3114	T4642	T4640	pobj	middle,in
R3115	T4643	T4642	prep	of,middle
R3116	T4644	T4643	pobj	Chromosome,of
R3117	T4645	T4644	nummod	3,Chromosome
R3118	T4646	T4638	punct	", ",position
R3119	T4647	T4638	amod	distal,position
R3120	T4648	T4647	prep	to,distal
R3121	T4649	T4648	amod	matted,to
R3122	T4650	T4647	cc	and,distal
R3123	T4651	T4647	conj	proximal,distal
R3124	T4652	T4651	prep	to,proximal
R3125	T4653	T4654	compound	Varitint,waddler
R3126	T4654	T4652	pobj	waddler,to
R3127	T4655	T4654	punct	-,waddler
R3128	T4656	T4657	punct	(,Carter
R3129	T4657	T4619	meta	Carter,identified
R3130	T4658	T4657	cc	and,Carter
R3131	T4659	T4657	conj	Falconer,Carter
R3132	T4660	T4659	nummod	1951,Falconer
R3133	T4661	T4659	punct	;,Falconer
R3134	T4662	T4659	conj	Curry,Falconer
R3135	T4663	T4662	nummod	1959,Curry
R3136	T4664	T4662	punct	;,Curry
R3137	T4665	T4662	conj	Lane,Curry
R3138	T4666	T4665	cc	and,Lane
R3139	T4667	T4665	conj	Eicher,Lane
R3140	T4668	T4667	nummod	1979,Eicher
R3141	T4669	T4667	punct	;,Eicher
R3142	T4670	T4667	conj	Holmes,Eicher
R3143	T4671	T4670	nmod	et,Holmes
R3144	T4672	T4670	nmod	al.,Holmes
R3145	T4673	T4670	nummod	1981,Holmes
R3146	T4674	T4670	punct	),Holmes
R3147	T4675	T4619	punct	.,identified
R3148	T4677	T4678	nsubj	We,used
R3149	T4679	T4680	det	an,intercross
R3150	T4680	T4678	dobj	intercross,used
R3151	T4681	T4680	compound	F2,intercross
R3152	T4682	T4680	prep	with,intercross
R3153	T4683	T4684	compound	CAST,Ei
R3154	T4684	T4686	compound	Ei,mice
R3155	T4685	T4684	punct	/,Ei
R3156	T4686	T4682	pobj	mice,with
R3157	T4687	T4688	aux	to,localize
R3158	T4688	T4678	advcl	localize,used
R3159	T4689	T4688	dobj	deH,localize
R3160	T4690	T4688	prep	to,localize
R3161	T4691	T4692	det	a,interval
R3162	T4692	T4690	pobj	interval,to
R3163	T4693	T4694	nummod	0.1,cM
R3164	T4694	T4692	compound	cM,interval
R3165	T4695	T4692	prep	between,interval
R3166	T4696	T4695	pobj	D3Mit213,between
R3167	T4697	T4696	cc	and,D3Mit213
R3168	T4698	T4696	conj	16.MMHAP32FLF1,D3Mit213
R3169	T4699	T4692	punct	", ",interval
R3170	T4700	T4701	dep	which,refined
R3171	T4701	T4692	relcl	refined,interval
R3172	T4702	T4701	auxpass	was,refined
R3173	T4703	T4701	prep	by,refined
R3174	T4704	T4703	pobj	development,by
R3175	T4705	T4704	prep	of,development
R3176	T4706	T4707	det	a,contig
R3177	T4707	T4705	pobj	contig,of
R3178	T4708	T4709	amod	bacterial,chromosome
R3179	T4709	T4707	nmod	chromosome,contig
R3180	T4710	T4709	amod	artificial,chromosome
R3181	T4711	T4709	punct	(,chromosome
R3182	T4712	T4709	appos	BAC,chromosome
R3183	T4713	T4707	punct	),contig
R3184	T4714	T4707	cc	and,contig
R3185	T4715	T4716	amod	additional,markers
R3186	T4716	T4707	conj	markers,contig
R3187	T4717	T4716	prep	to,markers
R3188	T4718	T4719	det	a,region
R3189	T4719	T4717	pobj	region,to
R3190	T4720	T4721	nummod	1.4,Mb
R3191	T4721	T4719	compound	Mb,region
R3192	T4722	T4723	dep	that,contained
R3193	T4723	T4719	relcl	contained,region
R3194	T4724	T4725	nummod	eight,genes
R3195	T4725	T4723	dobj	genes,contained
R3196	T4726	T4725	punct	", ",genes
R3197	T4727	T4725	prep	including,genes
R3198	T4728	T4727	pobj	Tbx15,including
R3199	T4729	T4730	punct	(,Figure
R3200	T4730	T4688	parataxis	Figure,localize
R3201	T4731	T4730	nummod	3A,Figure
R3202	T4732	T4730	punct	),Figure
R3203	T4733	T4678	punct	.,used
R3204	T4735	T4736	nsubj	We,considered
R3205	T4737	T4736	dobj	Tbx15,considered
R3206	T4738	T4736	prep	as,considered
R3207	T4739	T4740	det	an,candidate
R3208	T4740	T4738	pobj	candidate,as
R3209	T4741	T4740	amod	excellent,candidate
R3210	T4742	T4740	prep	for,candidate
R3211	T4743	T4744	det	the,abnormalities
R3212	T4744	T4742	pobj	abnormalities,for
R3213	T4745	T4744	amod	skeletal,abnormalities
R3214	T4746	T4744	acl	caused,abnormalities
R3215	T4747	T4746	agent	by,caused
R3216	T4748	T4747	pobj	deH,by
R3217	T4749	T4736	punct	", ",considered
R3218	T4750	T4736	prep	based,considered
R3219	T4751	T4750	prep	on,based
R3220	T4752	T4751	pobj	studies,on
R3221	T4753	T4752	prep	by,studies
R3222	T4754	T4753	pobj	Agulnik,by
R3223	T4755	T4756	advmod	et,al.
R3224	T4756	T4754	advmod	al.,Agulnik
R3225	T4757	T4754	punct	(,Agulnik
R3226	T4758	T4754	npadvmod	1998,Agulnik
R3227	T4759	T4754	punct	),Agulnik
R3228	T4760	T4754	punct	", ",Agulnik
R3229	T4761	T4762	dep	who,described
R3230	T4762	T4754	relcl	described,Agulnik
R3231	T4763	T4764	poss	its,expression
R3232	T4764	T4762	dobj	expression,described
R3233	T4765	T4764	amod	embryonic,expression
R3234	T4766	T4764	prep	in,expression
R3235	T4767	T4768	det	the,region
R3236	T4768	T4766	pobj	region,in
R3237	T4769	T4768	amod	craniofacial,region
R3238	T4770	T4768	cc	and,region
R3239	T4771	T4772	amod	developing,limbs
R3240	T4772	T4768	conj	limbs,region
R3241	T4773	T4736	punct	.,considered
R3242	T4775	T4776	advcl	Using,found
R3243	T4777	T4778	compound	sequence,information
R3244	T4778	T4775	dobj	information,Using
R3245	T4779	T4778	prep	from,information
R3246	T4780	T4779	pobj	Agulnik,from
R3247	T4781	T4782	advmod	et,al.
R3248	T4782	T4780	advmod	al.,Agulnik
R3249	T4783	T4780	punct	(,Agulnik
R3250	T4784	T4780	npadvmod	1998,Agulnik
R3251	T4785	T4780	punct	),Agulnik
R3252	T4786	T4778	cc	and,information
R3253	T4787	T4788	det	the,sequence
R3255	T4789	T4790	advmod	partially,completed
R3256	T4790	T4788	amod	completed,sequence
R3257	T4791	T4792	compound	mouse,genome
R3258	T4792	T4788	compound	genome,sequence
R3259	T4793	T4776	punct	", ",found
R3260	T4794	T4776	nsubj	we,found
R3261	T4795	T4796	mark	that,amplified
R3262	T4796	T4776	ccomp	amplified,found
R3263	T4797	T4796	nsubjpass	portions,amplified
R3264	T4798	T4797	prep	of,portions
R3265	T4799	T4800	amod	several,exons
R3266	T4800	T4798	pobj	exons,of
R3267	T4801	T4800	compound	Tbx15,exons
R3268	T4802	T4796	aux	could,amplified
R3269	T4803	T4796	neg	not,amplified
R3270	T4804	T4796	auxpass	be,amplified
R3271	T4805	T4796	prep	from,amplified
R3272	T4806	T4807	nmod	deH,deH
R3273	T4807	T4809	nmod	deH,DNA
R3274	T4808	T4807	punct	/,deH
R3275	T4809	T4805	pobj	DNA,from
R3276	T4810	T4809	amod	genomic,DNA
R3277	T4811	T4776	punct	.,found
R3278	T4813	T4814	det	The,gene
R3279	T4814	T4816	nsubjpass	gene,referred
R3280	T4815	T4814	amod	same,gene
R3281	T4817	T4816	auxpass	was,referred
R3282	T4818	T4816	advmod	initially,referred
R3283	T4819	T4816	prep	to,referred
R3284	T4820	T4816	prep	as,referred
R3285	T4821	T4820	pobj	Tbx8,as
R3286	T4822	T4823	punct	(,Wattler
R3287	T4823	T4816	meta	Wattler,referred
R3288	T4824	T4823	nmod	et,Wattler
R3289	T4825	T4823	nmod	al.,Wattler
R3290	T4826	T4823	nummod	1998,Wattler
R3291	T4827	T4823	punct	),Wattler
R3292	T4828	T4816	cc	and,referred
R3293	T4829	T4830	advmod	then,renamed
R3294	T4830	T4816	conj	renamed,referred
R3295	T4831	T4830	advmod	later,renamed
R3296	T4832	T4830	oprd	Tbx14,renamed
R3297	T4833	T4830	punct	", ",renamed
R3298	T4834	T4830	cc	but,renamed
R3299	T4835	T4836	auxpass	is,referred
R3300	T4836	T4830	conj	referred,renamed
R3301	T4837	T4836	advmod	currently,referred
R3302	T4838	T4836	prep	to,referred
R3303	T4839	T4836	prep	in,referred
R3304	T4840	T4841	amod	several,genomes
R3305	T4841	T4839	pobj	genomes,in
R3306	T4842	T4841	compound	vertebrate,genomes
R3307	T4843	T4836	prep	as,referred
R3308	T4844	T4843	pobj	Tbx15,as
R3309	T4845	T4846	punct	(,Agulnik
R3310	T4846	T4836	meta	Agulnik,referred
R3311	T4847	T4846	nmod	et,Agulnik
R3312	T4848	T4846	nmod	al.,Agulnik
R3313	T4849	T4846	nummod	1998,Agulnik
R3314	T4850	T4846	punct	;,Agulnik
R3315	T4851	T4846	nmod	Begemann,Agulnik
R3316	T4852	T4846	nmod	et,Agulnik
R3317	T4853	T4846	nmod	al.,Agulnik
R3318	T4854	T4846	nummod	2002,Agulnik
R3319	T4855	T4846	punct	),Agulnik
R3320	T4856	T4816	punct	.,referred
R3321	T4858	T4859	prep	By,identified
R3322	T4860	T4858	pcomp	comparing,By
R3323	T4861	T4862	det	the,sequence
R3324	T4862	T4860	dobj	sequence,comparing
R3325	T4863	T4862	prep	of,sequence
R3326	T4864	T4865	det	a,fragment
R3327	T4865	T4863	pobj	fragment,of
R3328	T4866	T4867	nummod	1.3,kb
R3329	T4867	T4868	compound	kb,junction
R3330	T4868	T4865	compound	junction,fragment
R3331	T4869	T4865	acl	amplified,fragment
R3332	T4870	T4869	prep	from,amplified
R3333	T4871	T4872	nmod	deH,deH
R3334	T4872	T4874	nmod	deH,DNA
R3335	T4873	T4872	punct	/,deH
R3336	T4874	T4870	pobj	DNA,from
R3337	T4875	T4874	amod	genomic,DNA
R3338	T4876	T4860	prep	to,comparing
R3339	T4877	T4878	advmod	publicly,available
R3340	T4878	T4879	amod	available,sequence
R3341	T4879	T4876	pobj	sequence,to
R3342	T4880	T4881	compound	mouse,genome
R3343	T4881	T4879	compound	genome,sequence
R3344	T4882	T4859	punct	", ",identified
R3345	T4883	T4859	nsubj	we,identified
R3346	T4884	T4885	det	a,deletion
R3347	T4885	T4859	dobj	deletion,identified
R3348	T4886	T4887	nummod	216,kb
R3349	T4887	T4885	compound	kb,deletion
R3350	T4888	T4889	dep	that,extends
R3351	T4889	T4885	relcl	extends,deletion
R3352	T4890	T4889	prep	from,extends
R3353	T4891	T4892	compound	Tbx15,intron
R3354	T4892	T4890	pobj	intron,from
R3355	T4893	T4892	nummod	1,intron
R3356	T4894	T4889	prep	to,extends
R3357	T4895	T4896	nummod	148,kb
R3358	T4896	T4897	npadvmod	kb,downstream
R3359	T4897	T4894	pcomp	downstream,to
R3360	T4898	T4897	prep	of,downstream
R3361	T4899	T4900	det	the,sequence
R3362	T4900	T4898	pobj	sequence,of
R3363	T4901	T4900	compound	polyadenylation,sequence
R3364	T4902	T4900	prep	in,sequence
R3365	T4903	T4904	det	a,region
R3366	T4904	T4902	pobj	region,in
R3367	T4905	T4904	acl	annotated,region
R3368	T4906	T4905	prep	as,annotated
R3369	T4907	T4908	det	a,pseudogene
R3370	T4908	T4906	pobj	pseudogene,as
R3371	T4909	T4910	nmod	mannose,phosphate
R3372	T4910	T4914	compound	phosphate,receptor
R3373	T4911	T4910	punct	-,phosphate
R3374	T4912	T4910	nummod	6,phosphate
R3375	T4913	T4910	punct	-,phosphate
R3376	T4914	T4908	compound	receptor,pseudogene
R3377	T4915	T4908	punct	", ",pseudogene
R3378	T4916	T4917	compound	M6pr,ps
R3379	T4917	T4908	appos	ps,pseudogene
R3380	T4918	T4917	punct	-,ps
R3381	T4919	T4920	punct	(,3B
R3382	T4920	T4859	parataxis	3B,identified
R3383	T4921	T4920	nmod	Figure,3B
R3384	T4922	T4920	cc	and,3B
R3385	T4923	T4920	conj	3C,3B
R3386	T4924	T4920	punct	),3B
R3387	T4925	T4859	punct	.,identified
R3388	T4927	T4928	punct	(,Ludwig
R3389	T4929	T4928	nmod	et,Ludwig
R3390	T4930	T4928	nmod	al.,Ludwig
R3391	T4931	T4928	nummod	1992,Ludwig
R3392	T4932	T4928	punct	),Ludwig
R3393	T4933	T4928	punct	.,Ludwig
R3394	T4935	T4936	prep	By,identified
R3395	T4937	T4938	compound	Northern,blot
R3396	T4938	T4939	compound	blot,analysis
R3397	T4939	T4935	pobj	analysis,By
R3398	T4940	T4936	punct	", ",identified
R3399	T4941	T4936	nsubj	we,identified
R3400	T4942	T4943	det	a,transcript
R3401	T4943	T4936	dobj	transcript,identified
R3402	T4944	T4943	compound	fusion,transcript
R3403	T4945	T4943	acl	produced,transcript
R3404	T4946	T4945	prep	from,produced
R3405	T4947	T4948	det	the,chromosome
R3406	T4948	T4946	pobj	chromosome,from
R3407	T4949	T4948	compound	deH,chromosome
R3408	T4950	T4951	punct	(,shown
R3409	T4951	T4936	parataxis	shown,identified
R3410	T4952	T4951	nsubj	data,shown
R3411	T4953	T4951	neg	not,shown
R3412	T4954	T4951	punct	),shown
R3413	T4955	T4936	punct	.,identified
R3414	T4957	T4958	advmod	However,removes
R3415	T4959	T4958	punct	", ",removes
R3416	T4960	T4961	det	the,deletion
R3417	T4961	T4958	nsubj	deletion,removes
R3418	T4962	T4963	quantmod	534,602
R3419	T4963	T4966	nummod	602,acids
R3420	T4964	T4963	quantmod	of,602
R3421	T4965	T4963	quantmod	the,602
R3422	T4966	T4958	dobj	acids,removes
R3423	T4967	T4966	compound	amino,acids
R3424	T4968	T4966	acl	encoded,acids
R3425	T4969	T4968	agent	by,encoded
R3426	T4970	T4969	pobj	Tbx15,by
R3427	T4971	T4966	punct	(,acids
R3428	T4972	T4966	prep	including,acids
R3429	T4973	T4974	det	the,domain
R3430	T4974	T4972	pobj	domain,including
R3431	T4975	T4976	nmod	T,box
R3432	T4976	T4974	nmod	box,domain
R3433	T4977	T4976	punct	-,box
R3434	T4978	T4979	npadvmod	DNA,binding
R3435	T4979	T4974	amod	binding,domain
R3436	T4980	T4979	punct	-,binding
R3437	T4981	T4958	punct	),removes
R3438	T4982	T4958	punct	", ",removes
R3439	T4983	T4984	nmod	deH,animals
R3440	T4984	T4987	nsubj	animals,are
R3441	T4985	T4983	punct	/,deH
R3442	T4986	T4983	punct	+,deH
R3443	T4987	T4958	conj	are,removes
R3444	T4988	T4989	advmod	grossly,normal
R3445	T4989	T4987	acomp	normal,are
R3446	T4990	T4987	punct	", ",are
R3447	T4991	T4987	cc	and,are
R3448	T4992	T4993	det	the,phenotype
R3449	T4993	T4994	nsubj	phenotype,is
R3450	T4994	T4987	conj	is,are
R3451	T4995	T4993	prep	of,phenotype
R3452	T4996	T4997	compound	deH,deH
R3453	T4997	T4999	compound	deH,animals
R3454	T4998	T4997	punct	/,deH
R3455	T4999	T4995	pobj	animals,of
R3456	T5000	T4994	acomp	identical,is
R3457	T5001	T5000	prep	to,identical
R3458	T5002	T5001	pobj	that,to
R3459	T5003	T5002	acl	described,that
R3460	T5004	T5003	prep	for,described
R3461	T5005	T5006	det	the,allele
R3462	T5006	T5004	pobj	allele,for
R3463	T5007	T5006	amod	original,allele
R3464	T5008	T4994	punct	.,is
R3465	T5010	T5011	prep	In,annotated
R3466	T5012	T5010	pobj	addition,In
R3467	T5013	T5011	punct	", ",annotated
R3468	T5014	T5011	amod	other,annotated
R3469	T5015	T5014	prep	than,other
R3470	T5016	T5017	compound	M6pr,ps
R3471	T5017	T5015	pobj	ps,than
R3472	T5018	T5017	punct	-,ps
R3473	T5019	T5011	punct	", ",annotated
R3474	T5020	T5021	det	no,genes
R3475	T5021	T5011	nsubjpass	genes,annotated
R3476	T5022	T5021	amod	other,genes
R3477	T5023	T5021	cc	or,genes
R3478	T5024	T5021	conj	transcripts,genes
R3479	T5025	T5011	aux	have,annotated
R3480	T5026	T5011	auxpass	been,annotated
R3481	T5027	T5011	prep	to,annotated
R3482	T5028	T5029	det	the,deletion
R3483	T5029	T5027	pobj	deletion,to
R3484	T5030	T5031	nummod	216,kb
R3485	T5031	T5029	compound	kb,deletion
R3486	T5032	T5011	punct	.,annotated
R3487	T5034	T5035	mark	While,was
R3489	T5036	T5037	det	the,work
R3490	T5037	T5035	nsubj	work,was
R3491	T5038	T5037	amod	positional,work
R3492	T5039	T5037	compound	cloning,work
R3493	T5041	T5035	advmod	underway,was
R3494	T5042	T5040	punct	", ",generated
R3495	T5043	T5040	nsubj	one,generated
R3496	T5044	T5043	prep	of,one
R3497	T5045	T5044	pobj	us,of
R3498	T5046	T5043	punct	(,one
R3499	T5047	T5048	compound	A.,Russ
R3500	T5048	T5043	appos	Russ,one
R3501	T5049	T5043	punct	),one
R3502	T5050	T5051	det	an,mutation
R3503	T5051	T5040	dobj	mutation,generated
R3504	T5052	T5051	amod	independent,mutation
R3505	T5053	T5051	prep	of,mutation
R3506	T5054	T5053	pobj	Tbx15,of
R3507	T5055	T5040	prep	by,generated
R3508	T5056	T5057	compound	gene,targeting
R3509	T5057	T5055	pobj	targeting,by
R3510	T5058	T5057	prep	in,targeting
R3511	T5059	T5060	amod	embryonic,cells
R3512	T5060	T5058	pobj	cells,in
R3513	T5061	T5060	compound	stem,cells
R3514	T5062	T5040	punct	.,generated
R3515	T5064	T5065	det	The,allele
R3516	T5065	T5067	nsubj	allele,carries
R3517	T5066	T5065	amod	targeted,allele
R3518	T5068	T5065	punct	", ",allele
R3519	T5069	T5065	appos	Tbx15LacZ,allele
R3520	T5070	T5067	punct	", ",carries
R3521	T5071	T5072	det	an,cassette
R3522	T5072	T5067	dobj	cassette,carries
R3523	T5073	T5074	nmod	IRES,LacZ
R3524	T5074	T5072	nmod	LacZ,cassette
R3525	T5075	T5074	punct	-,LacZ
R3526	T5076	T5074	punct	-,LacZ
R3527	T5077	T5074	amod	neo,LacZ
R3528	T5078	T5072	compound	cDNA,cassette
R3529	T5079	T5080	dep	that,disrupts
R3530	T5080	T5072	relcl	disrupts,cassette
R3531	T5081	T5082	det	the,frame
R3532	T5082	T5080	dobj	frame,disrupts
R3533	T5083	T5082	amod	open,frame
R3534	T5084	T5082	compound	reading,frame
R3535	T5085	T5082	prep	at,frame
R3536	T5086	T5085	pobj	codon,at
R3537	T5087	T5086	nummod	154,codon
R3538	T5088	T5080	advmod	early,disrupts
R3539	T5089	T5080	prep	in,disrupts
R3540	T5090	T5091	det	the,domain
R3541	T5091	T5089	pobj	domain,in
R3542	T5092	T5093	compound	T,box
R3543	T5093	T5091	compound	box,domain
R3544	T5094	T5093	punct	-,box
R3545	T5095	T5096	punct	(,Figure
R3546	T5096	T5080	parataxis	Figure,disrupts
R3547	T5097	T5096	nummod	3D,Figure
R3548	T5098	T5096	punct	),Figure
R3549	T5099	T5067	punct	.,carries
R3550	T5101	T5102	nsubj	Animals,are
R3551	T5103	T5101	amod	heterozygous,Animals
R3552	T5104	T5103	prep	for,heterozygous
R3553	T5105	T5106	det	the,allele
R3554	T5106	T5104	pobj	allele,for
R3555	T5107	T5106	amod	targeted,allele
R3556	T5108	T5109	advmod	completely,normal
R3557	T5109	T5102	acomp	normal,are
R3558	T5110	T5102	prep	with,are
R3559	T5111	T5110	pobj	regard,with
R3560	T5112	T5111	prep	to,regard
R3561	T5113	T5112	pobj	size,to
R3562	T5114	T5113	punct	", ",size
R3563	T5115	T5116	amod	skeletal,morphology
R3564	T5116	T5113	conj	morphology,size
R3565	T5117	T5116	punct	", ",morphology
R3566	T5118	T5116	cc	and,morphology
R3567	T5119	T5120	compound	hair,color
R3568	T5120	T5122	compound	color,distribution
R3569	T5121	T5120	punct	-,color
R3570	T5122	T5116	conj	distribution,morphology
R3571	T5123	T5102	punct	", ",are
R3572	T5124	T5102	cc	but,are
R3573	T5125	T5126	compound	Tbx15LacZ,Tbx15LacZ
R3574	T5126	T5128	compound	Tbx15LacZ,homozygotes
R3575	T5127	T5126	punct	/,Tbx15LacZ
R3576	T5128	T5129	nsubjpass	homozygotes,noted
R3577	T5129	T5102	conj	noted,are
R3578	T5130	T5129	auxpass	were,noted
R3579	T5131	T5132	aux	to,exhibit
R3580	T5132	T5129	xcomp	exhibit,noted
R3581	T5133	T5134	amod	reduced,size
R3582	T5134	T5132	dobj	size,exhibit
R3583	T5135	T5134	compound	body,size
R3584	T5136	T5134	cc	and,size
R3585	T5137	T5138	det	an,appearance
R3586	T5138	T5134	conj	appearance,size
R3587	T5139	T5138	amod	abnormal,appearance
R3588	T5140	T5138	amod	craniofacial,appearance
R3589	T5141	T5138	amod	identical,appearance
R3590	T5142	T5141	prep	to,identical
R3591	T5143	T5142	pobj	that,to
R3592	T5144	T5143	acl	caused,that
R3593	T5145	T5144	agent	by,caused
R3594	T5146	T5145	pobj	deH,by
R3595	T5147	T5129	punct	.,noted
R3596	T5149	T5150	nsubj	We,generated
R3597	T5150	T5151	ccomp	generated,exhibited
R3598	T5152	T5153	nmod	Tbx15LacZ,deH
R3599	T5153	T5155	compound	deH,heterozygotes
R3600	T5154	T5153	punct	/,deH
R3601	T5155	T5150	dobj	heterozygotes,generated
R3602	T5156	T5155	compound	compound,heterozygotes
R3603	T5157	T5151	punct	;,exhibited
R3604	T5158	T5151	prep	on,exhibited
R3605	T5159	T5160	det	an,background
R3606	T5160	T5158	pobj	background,on
R3607	T5161	T5162	compound	Aw,at
R3608	T5162	T5160	compound	at,background
R3609	T5163	T5162	punct	/,at
R3610	T5164	T5151	punct	", ",exhibited
R3611	T5165	T5166	det	these,animals
R3612	T5166	T5151	nsubj	animals,exhibited
R3613	T5167	T5168	det	the,restriction
R3614	T5168	T5151	dobj	restriction,exhibited
R3615	T5169	T5168	amod	same,restriction
R3616	T5170	T5168	amod	abnormal,restriction
R3617	T5171	T5168	prep	of,restriction
R3618	T5172	T5173	amod	dorsal,pigmentation
R3619	T5173	T5171	pobj	pigmentation,of
R3620	T5174	T5168	prep	at,restriction
R3621	T5175	T5174	pobj	P3.5,at
R3622	T5176	T5168	cc	and,restriction
R3623	T5177	T5178	amod	expanded,area
R3624	T5178	T5168	conj	area,restriction
R3625	T5179	T5178	amod	yellow,area
R3626	T5180	T5178	compound	flank,area
R3627	T5181	T5182	mark	as,described
R3628	T5182	T5151	advcl	described,exhibited
R3629	T5183	T5182	advmod	above,described
R3630	T5184	T5182	prep	for,described
R3631	T5185	T5186	compound	deH,deH
R3632	T5186	T5188	compound	deH,animals
R3633	T5187	T5186	punct	/,deH
R3634	T5188	T5184	pobj	animals,for
R3635	T5189	T5190	punct	(,see
R3636	T5190	T5151	parataxis	see,exhibited
R3637	T5191	T5190	dobj	Figure,see
R3638	T5192	T5191	nummod	2,Figure
R3639	T5193	T5190	punct	),see
R3640	T5194	T5151	punct	.,exhibited
R3641	T5196	T5197	det	These,observations
R3642	T5197	T5198	nsubj	observations,demonstrate
R3643	T5199	T5200	mark	that,caused
R3644	T5200	T5198	ccomp	caused,demonstrate
R3645	T5201	T5202	det	the,characteristics
R3646	T5202	T5200	nsubjpass	characteristics,caused
R3647	T5203	T5202	amod	pigmentary,characteristics
R3648	T5204	T5203	cc	and,pigmentary
R3649	T5205	T5203	conj	craniofacial,pigmentary
R3650	T5206	T5202	prep	of,characteristics
R3651	T5207	T5206	pobj	deH,of
R3652	T5208	T5200	auxpass	are,caused
R3653	T5209	T5200	agent	by,caused
R3654	T5210	T5209	pobj	loss,by
R3655	T5211	T5210	prep	of,loss
R3656	T5212	T5211	pobj	function,of
R3657	T5213	T5210	prep	for,loss
R3658	T5214	T5213	pobj	Tbx15,for
R3659	T5215	T5198	punct	.,demonstrate
R3666	T5466	T5465	prep	of,Expression
R3667	T5467	T5466	pobj	Tbx15,of
R3668	T5468	T5467	cc	and,Tbx15
R3669	T5469	T5467	conj	Agouti,Tbx15
R3670	T5471	T5472	amod	Previous,studies
R3671	T5472	T5473	nsubj	studies,described
R3672	T5474	T5472	prep	by,studies
R3673	T5475	T5474	pobj	Agulnik,by
R3674	T5476	T5477	advmod	et,al.
R3675	T5477	T5475	advmod	al.,Agulnik
R3676	T5478	T5475	punct	(,Agulnik
R3677	T5479	T5475	npadvmod	1998,Agulnik
R3678	T5480	T5475	punct	),Agulnik
R3679	T5481	T5472	acl	using,studies
R3680	T5482	T5483	amod	whole,mount
R3681	T5483	T5485	nmod	mount,hybridization
R3682	T5484	T5483	punct	-,mount
R3683	T5485	T5481	dobj	hybridization,using
R3684	T5486	T5487	advmod	in,situ
R3685	T5487	T5485	amod	situ,hybridization
R3686	T5488	T5473	dobj	expression,described
R3687	T5489	T5488	prep	of,expression
R3688	T5490	T5489	pobj	Tbx15,of
R3689	T5491	T5473	prep	as,described
R3690	T5492	T5493	advmod	first,detectable
R3691	T5493	T5491	pcomp	detectable,as
R3692	T5494	T5493	prep	at,detectable
R3693	T5495	T5494	pobj	E9.5,at
R3694	T5496	T5493	prep	in,detectable
R3695	T5497	T5498	det	the,buds
R3696	T5498	T5496	pobj	buds,in
R3697	T5499	T5498	compound	limb,buds
R3698	T5500	T5493	punct	", ",detectable
R3699	T5501	T5493	advcl	progressing,detectable
R3700	T5502	T5501	prep	to,progressing
R3701	T5503	T5504	det	the,arches
R3702	T5504	T5502	pobj	arches,to
R3703	T5505	T5504	amod	branchial,arches
R3704	T5506	T5504	punct	", ",arches
R3705	T5507	T5504	conj	flanks,arches
R3706	T5508	T5507	punct	", ",flanks
R3707	T5509	T5507	cc	and,flanks
R3708	T5510	T5511	amod	craniofacial,regions
R3709	T5511	T5507	conj	regions,flanks
R3710	T5512	T5501	prep	through,progressing
R3711	T5513	T5512	pobj	E12.5,through
R3712	T5514	T5473	punct	.,described
R3713	T5516	T5517	aux	To,investigate
R3714	T5517	T5518	advcl	investigate,hybridized
R3715	T5519	T5520	det	this,pattern
R3716	T5520	T5517	dobj	pattern,investigate
R3717	T5521	T5517	prep	in,investigate
R3718	T5522	T5523	amod	more,detail
R3719	T5523	T5521	pobj	detail,in
R3720	T5524	T5518	punct	", ",hybridized
R3721	T5525	T5518	nsubj	we,hybridized
R3722	T5526	T5527	det	a,probe
R3723	T5527	T5518	dobj	probe,hybridized
R3724	T5528	T5527	compound	Tbx15,probe
R3725	T5529	T5527	compound	mRNA,probe
R3726	T5530	T5518	prep	to,hybridized
R3727	T5531	T5532	det	a,series
R3728	T5532	T5530	pobj	series,to
R3729	T5533	T5532	prep	of,series
R3730	T5534	T5535	amod	transverse,sections
R3731	T5535	T5533	pobj	sections,of
R3732	T5536	T5518	prep	at,hybridized
R3733	T5537	T5536	pobj	E12.5,at
R3734	T5538	T5518	cc	and,hybridized
R3735	T5539	T5518	conj	observed,hybridized
R3736	T5540	T5539	dobj	expression,observed
R3737	T5541	T5540	prep	in,expression
R3738	T5542	T5543	amod	multiple,tissues
R3739	T5543	T5541	pobj	tissues,in
R3740	T5544	T5543	amod	mesenchymal,tissues
R3741	T5545	T5543	prep	of,tissues
R3742	T5546	T5547	det	the,head
R3743	T5547	T5545	pobj	head,of
R3744	T5548	T5547	punct	", ",head
R3745	T5549	T5547	conj	trunk,head
R3746	T5550	T5549	punct	", ",trunk
R3747	T5551	T5549	cc	and,trunk
R3748	T5552	T5553	amod	developing,limbs
R3749	T5553	T5549	conj	limbs,trunk
R3750	T5554	T5555	punct	(,Figure
R3751	T5555	T5540	parataxis	Figure,expression
R3752	T5556	T5555	nummod	4A,Figure
R3753	T5557	T5555	punct	),Figure
R3754	T5558	T5540	punct	", ",expression
R3755	T5559	T5560	dep	much,is
R3756	T5560	T5540	relcl	is,expression
R3757	T5561	T5559	prep	of,much
R3758	T5562	T5561	pobj	which,of
R3759	T5563	T5560	acomp	consistent,is
R3760	T5564	T5563	prep	with,consistent
R3761	T5565	T5566	det	the,malformations
R3762	T5566	T5564	pobj	malformations,with
R3763	T5567	T5566	nmod	skull,malformations
R3764	T5568	T5567	punct	", ",skull
R3765	T5569	T5570	amod	cervical,vertebrae
R3766	T5570	T5567	conj	vertebrae,skull
R3767	T5571	T5570	punct	", ",vertebrae
R3768	T5572	T5570	cc	and,vertebrae
R3769	T5573	T5570	conj	limb,vertebrae
R3770	T5574	T5566	acl	reported,malformations
R3771	T5575	T5574	prep	for,reported
R3772	T5576	T5575	pobj	mice,for
R3773	T5577	T5576	acl	carrying,mice
R3774	T5578	T5579	det	the,allele
R3775	T5579	T5577	dobj	allele,carrying
R3776	T5580	T5579	amod	original,allele
R3777	T5581	T5582	amod	droopy,ear
R3778	T5582	T5579	compound	ear,allele
R3779	T5583	T5518	punct	.,hybridized
R3780	T5585	T5586	nsubj	We,were
R3781	T5587	T5588	advmod	particularly,interested
R3782	T5588	T5586	acomp	interested,were
R3783	T5589	T5588	prep	in,interested
R3784	T5590	T5589	pcomp	determining,in
R3785	T5591	T5592	det	the,nature
R3786	T5592	T5590	dobj	nature,determining
R3787	T5593	T5592	amod	exact,nature
R3788	T5594	T5592	prep	of,nature
R3789	T5595	T5596	det	the,expression
R3790	T5596	T5594	pobj	expression,of
R3791	T5597	T5596	amod	embryonic,expression
R3792	T5598	T5596	compound	flank,expression
R3793	T5599	T5592	amod	relative,nature
R3794	T5600	T5599	prep	to,relative
R3795	T5601	T5602	det	the,phenotype
R3796	T5602	T5600	pobj	phenotype,to
R3797	T5603	T5602	amod	ventralized,phenotype
R3798	T5604	T5602	prep	of,phenotype
R3799	T5605	T5606	amod	adult,mice
R3800	T5606	T5604	pobj	mice,of
R3801	T5607	T5608	nmod	deH,deH
R3802	T5608	T5606	compound	deH,mice
R3803	T5609	T5608	punct	/,deH
R3804	T5610	T5586	punct	.,were
R3805	T5612	T5613	amod	Transverse,sections
R3806	T5613	T5615	nsubj	sections,reveal
R3807	T5614	T5613	amod	abdominal,sections
R3808	T5616	T5613	prep	from,sections
R3809	T5617	T5618	amod	different,times
R3810	T5618	T5616	pobj	times,from
R3811	T5619	T5618	prep	during,times
R3812	T5620	T5619	pobj	development,during
R3813	T5621	T5622	det	a,band
R3814	T5622	T5615	dobj	band,reveal
R3815	T5623	T5622	amod	dorsolateral,band
R3816	T5624	T5622	prep	of,band
R3817	T5625	T5624	pobj	expression,of
R3818	T5626	T5622	prep	in,band
R3819	T5627	T5628	det	the,mesenchyme
R3820	T5628	T5626	pobj	mesenchyme,in
R3821	T5629	T5628	amod	superficial,mesenchyme
R3822	T5630	T5622	prep	at,band
R3823	T5631	T5630	pobj	E11.5,at
R3824	T5632	T5633	dep	that,broadens
R3825	T5633	T5622	relcl	broadens,band
R3826	T5634	T5635	preconj	both,dorsally
R3827	T5635	T5633	advmod	dorsally,broadens
R3828	T5636	T5635	cc	and,dorsally
R3829	T5637	T5635	conj	ventrally,dorsally
R3830	T5638	T5633	prep	over,broadens
R3831	T5639	T5640	det	the,days
R3832	T5640	T5638	pobj	days,over
R3833	T5641	T5640	amod	next,days
R3834	T5642	T5640	amod	several,days
R3835	T5643	T5644	punct	(,Figure
R3836	T5644	T5633	parataxis	Figure,broadens
R3837	T5645	T5644	nummod	4B,Figure
R3838	T5646	T5644	punct	),Figure
R3839	T5647	T5615	punct	.,reveal
R3840	T5649	T5650	prep	By,become
R3841	T5650	T5657	ccomp	become,expressed
R3842	T5651	T5649	pobj	E13.5,By
R3843	T5652	T5650	punct	", ",become
R3844	T5653	T5654	det	the,dermis
R3845	T5654	T5650	nsubj	dermis,become
R3846	T5655	T5654	amod	developing,dermis
R3847	T5656	T5650	aux	has,become
R3848	T5658	T5650	acomp	separated,become
R3849	T5659	T5658	prep	from,separated
R3850	T5660	T5661	det	the,mesenchyme
R3851	T5661	T5659	pobj	mesenchyme,from
R3852	T5662	T5661	amod	loose,mesenchyme
R3853	T5663	T5650	prep	by,become
R3854	T5664	T5665	det	a,layer
R3855	T5665	T5663	pobj	layer,by
R3856	T5666	T5665	amod	subcutaneous,layer
R3857	T5667	T5665	compound	muscle,layer
R3858	T5668	T5657	punct	;,expressed
R3859	T5669	T5657	nsubjpass	Tbx15,expressed
R3860	T5670	T5657	auxpass	is,expressed
R3861	T5671	T5657	prep	in,expressed
R3862	T5672	T5671	pobj	all,in
R3863	T5673	T5672	prep	of,all
R3864	T5674	T5675	det	these,layers
R3865	T5675	T5673	pobj	layers,of
R3866	T5676	T5677	advmod	as,as
R3867	T5677	T5672	cc	as,all
R3868	T5678	T5677	advmod	well,as
R3869	T5679	T5680	det	the,muscles
R3870	T5680	T5672	conj	muscles,all
R3871	T5681	T5680	amod	underlying,muscles
R3872	T5682	T5680	amod	abdominal,muscles
R3873	T5683	T5657	punct	.,expressed
R3874	T5685	T5686	prep	In,expressed
R3875	T5686	T5692	ccomp	expressed,detected
R3876	T5687	T5688	compound	P3.5,skin
R3877	T5688	T5685	pobj	skin,In
R3878	T5689	T5686	punct	", ",expressed
R3879	T5690	T5686	nsubjpass	Tbx15,expressed
R3880	T5691	T5686	auxpass	is,expressed
R3881	T5693	T5686	prep	in,expressed
R3882	T5694	T5695	preconj	both,dorsal
R3883	T5695	T5696	amod	dorsal,skin
R3884	T5696	T5693	pobj	skin,in
R3885	T5697	T5695	cc	and,dorsal
R3886	T5698	T5695	conj	ventral,dorsal
R3887	T5699	T5686	punct	", ",expressed
R3888	T5700	T5701	advmod	most,strongly
R3889	T5701	T5686	advmod	strongly,expressed
R3890	T5702	T5701	prep	in,strongly
R3891	T5703	T5704	det	the,dermis
R3892	T5704	T5702	pobj	dermis,in
R3893	T5705	T5704	amod	condensed,dermis
R3894	T5706	T5704	amod	upper,dermis
R3895	T5707	T5704	cc	and,dermis
R3896	T5708	T5709	amod	developing,sheaths
R3897	T5709	T5704	conj	sheaths,dermis
R3898	T5710	T5709	amod	dermal,sheaths
R3899	T5711	T5704	prep	of,dermis
R3900	T5712	T5713	compound	hair,follicles
R3901	T5713	T5711	pobj	follicles,of
R3902	T5714	T5692	punct	;,detected
R3903	T5715	T5716	amod	faint,expression
R3904	T5716	T5692	nsubjpass	expression,detected
R3905	T5717	T5692	aux	can,detected
R3906	T5718	T5692	advmod	also,detected
R3907	T5719	T5692	auxpass	be,detected
R3908	T5720	T5692	prep	in,detected
R3909	T5721	T5722	amod	rare,cells
R3910	T5722	T5720	pobj	cells,in
R3911	T5723	T5722	amod	dermal,cells
R3912	T5724	T5722	compound	papillae,cells
R3913	T5725	T5726	punct	(,Figure
R3914	T5726	T5692	parataxis	Figure,detected
R3915	T5727	T5726	nummod	4B,Figure
R3916	T5728	T5726	punct	),Figure
R3917	T5729	T5692	punct	.,detected
R3918	T5731	T5732	mark	Although,occur
R3919	T5732	T5742	advcl	occur,expressed
R3920	T5733	T5734	det	the,effects
R3921	T5734	T5732	nsubj	effects,occur
R3922	T5735	T5734	prep	of,effects
R3923	T5736	T5735	pobj	Agouti,of
R3924	T5737	T5734	prep	on,effects
R3925	T5738	T5739	compound	pigment,type
R3926	T5739	T5737	pobj	type,on
R3927	T5740	T5739	punct	-,type
R3928	T5741	T5739	amod	switching,type
R3929	T5743	T5732	prep	during,occur
R3930	T5744	T5745	amod	postnatal,growth
R3931	T5745	T5743	pobj	growth,during
R3932	T5746	T5745	compound	hair,growth
R3933	T5747	T5742	punct	", ",expressed
R3934	T5748	T5749	det	the,isoform
R3935	T5749	T5742	nsubjpass	isoform,expressed
R3936	T5750	T5751	amod	ventral,specific
R3937	T5751	T5749	amod	specific,isoform
R3938	T5752	T5751	punct	-,specific
R3939	T5753	T5749	prep	of,isoform
R3940	T5754	T5753	pobj	Agouti,of
R3941	T5755	T5742	auxpass	is,expressed
R3942	T5756	T5742	prep	in,expressed
R3943	T5757	T5758	amod	developing,skin
R3944	T5758	T5756	pobj	skin,in
R3945	T5759	T5742	advcl	beginning,expressed
R3946	T5760	T5759	prep	at,beginning
R3947	T5761	T5760	pobj	E11.5,at
R3948	T5762	T5742	punct	.,expressed
R3949	T5764	T5765	nsubj	We,compared
R3950	T5766	T5767	amod	adjacent,sections
R3951	T5767	T5765	dobj	sections,compared
R3952	T5768	T5767	acl	hybridized,sections
R3953	T5769	T5768	prep	with,hybridized
R3954	T5770	T5769	pobj	probes,with
R3955	T5771	T5770	prep	for,probes
R3956	T5772	T5771	pobj	Tbx15,for
R3957	T5773	T5772	cc	and,Tbx15
R3958	T5774	T5772	conj	Agouti,Tbx15
R3959	T5775	T5776	cc	and,observed
R3960	T5776	T5765	dep	observed,compared
R3961	T5777	T5778	amod	complementary,patterns
R3962	T5778	T5776	dobj	patterns,observed
R3963	T5779	T5776	prep	at,observed
R3964	T5780	T5779	pobj	E12.5,at
R3965	T5781	T5776	punct	", ",observed
R3966	T5782	T5783	mark	with,expression
R3967	T5783	T5776	advcl	expression,observed
R3968	T5784	T5783	prep	of,expression
R3969	T5785	T5784	pobj	Agouti,of
R3970	T5786	T5783	prep	in,expression
R3971	T5787	T5788	amod	ventral,skin
R3972	T5788	T5786	pobj	skin,in
R3973	T5789	T5783	cc	and,expression
R3974	T5790	T5783	conj	expression,expression
R3975	T5791	T5790	prep	of,expression
R3976	T5792	T5791	pobj	Tbx15,of
R3977	T5793	T5790	prep	in,expression
R3978	T5794	T5795	amod	dorsal,skin
R3979	T5795	T5793	pobj	skin,in
R3980	T5796	T5797	punct	(,5A
R3981	T5797	T5776	parataxis	5A,observed
R3982	T5798	T5797	nmod	Figure,5A
R3983	T5799	T5797	cc	and,5A
R3984	T5800	T5797	conj	5B,5A
R3985	T5801	T5797	punct	),5A
R3986	T5802	T5765	punct	.,compared
R3987	T5804	T5805	det	The,junction
R3988	T5805	T5806	nsubj	junction,is
R3989	T5807	T5805	prep	between,junction
R3990	T5808	T5809	compound	expression,domains
R3991	T5809	T5807	pobj	domains,between
R3992	T5810	T5806	acomp	indistinct,is
R3993	T5811	T5806	punct	", ",is
R3994	T5812	T5806	cc	and,is
R3995	T5813	T5814	prep	by,extends
R3996	T5814	T5806	conj	extends,is
R3997	T5815	T5813	pobj	E14.5,by
R3998	T5816	T5814	punct	", ",extends
R3999	T5817	T5818	compound	Tbx15,expression
R4000	T5818	T5814	nsubj	expression,extends
R4001	T5819	T5814	advmod	ventrally,extends
R4002	T5820	T5814	cc	and,extends
R4003	T5821	T5814	conj	overlaps,extends
R4004	T5822	T5821	advmod	extensively,overlaps
R4005	T5823	T5821	prep	with,overlaps
R4006	T5824	T5825	compound	Agouti,expression
R4007	T5825	T5823	pobj	expression,with
R4008	T5826	T5827	punct	(,5C
R4009	T5827	T5821	parataxis	5C,overlaps
R4010	T5828	T5827	nmod	Figure,5C
R4011	T5829	T5827	cc	and,5C
R4012	T5830	T5827	conj	5D,5C
R4013	T5831	T5827	punct	),5C
R4014	T5832	T5814	punct	.,extends
R4015	T5834	T5835	nsubj	We,examined
R4016	T5836	T5835	advmod	also,examined
R4017	T5837	T5838	det	the,effect
R4018	T5838	T5835	dobj	effect,examined
R4019	T5839	T5838	prep	of,effect
R4020	T5840	T5839	pobj	deH,of
R4021	T5841	T5838	prep	on,effect
R4022	T5842	T5841	pobj	expression,on
R4023	T5843	T5842	prep	of,expression
R4024	T5844	T5843	pobj	Agouti,of
R4025	T5845	T5835	cc	and,examined
R4026	T5846	T5835	conj	found,examined
R4027	T5847	T5848	det	no,difference
R4028	T5848	T5846	dobj	difference,found
R4029	T5849	T5848	prep	between,difference
R4030	T5850	T5849	pobj	mutant,between
R4031	T5851	T5850	cc	and,mutant
R4032	T5852	T5850	conj	nonmutant,mutant
R4033	T5853	T5846	prep	at,found
R4034	T5854	T5853	pobj	E12.5,at
R4035	T5855	T5854	cc	or,E12.5
R4036	T5856	T5854	conj	E13.5,E12.5
R4037	T5857	T5858	punct	(,shown
R4038	T5858	T5846	parataxis	shown,found
R4039	T5859	T5858	nsubj	data,shown
R4040	T5860	T5858	neg	not,shown
R4041	T5861	T5858	punct	),shown
R4042	T5862	T5835	punct	.,examined
R4043	T5864	T5865	advmod	However,appeared
R4044	T5866	T5865	punct	", ",appeared
R4045	T5867	T5865	prep	at,appeared
R4046	T5868	T5867	pobj	E14.5,at
R4047	T5869	T5865	punct	", ",appeared
R4048	T5870	T5871	det	the,gradient
R4049	T5871	T5865	nsubj	gradient,appeared
R4050	T5872	T5871	amod	normal,gradient
R4051	T5873	T5871	amod	ventral,gradient
R4052	T5874	T5873	punct	-,ventral
R4053	T5875	T5873	prep	to,ventral
R4054	T5876	T5875	punct	-,to
R4055	T5877	T5875	amod	dorsal,to
R4056	T5878	T5871	prep	of,gradient
R4057	T5879	T5880	compound	Agouti,expression
R4058	T5880	T5878	pobj	expression,of
R4059	T5881	T5882	aux	to,extend
R4060	T5882	T5865	xcomp	extend,appeared
R4061	T5883	T5884	advmod	more,dorsally
R4062	T5884	T5882	advmod	dorsally,extend
R4063	T5885	T5882	prep	in,extend
R4064	T5886	T5887	compound	deH,deH
R4065	T5887	T5889	compound	deH,embryos
R4066	T5888	T5887	punct	/,deH
R4067	T5889	T5885	pobj	embryos,in
R4068	T5890	T5891	punct	(,Figure
R4069	T5891	T5882	parataxis	Figure,extend
R4070	T5892	T5891	nummod	6A,Figure
R4071	T5893	T5891	punct	),Figure
R4072	T5894	T5865	punct	.,appeared
R4073	T5896	T5897	prep	In,extended
R4074	T5898	T5899	compound	P4.5,skin
R4075	T5899	T5896	pobj	skin,In
R4076	T5900	T5897	punct	", ",extended
R4077	T5901	T5897	nsubjpass	expression,extended
R4078	T5902	T5901	prep	of,expression
R4079	T5903	T5902	pobj	Agouti,of
R4080	T5904	T5897	auxpass	is,extended
R4081	T5905	T5897	advmod	also,extended
R4082	T5906	T5897	advmod	dorsally,extended
R4083	T5907	T5897	prep	in,extended
R4084	T5908	T5909	compound	deH,deH
R4085	T5909	T5911	compound	deH,animals
R4086	T5910	T5909	punct	/,deH
R4087	T5911	T5907	pobj	animals,in
R4088	T5912	T5897	cc	and,extended
R4089	T5913	T5897	conj	is,extended
R4090	T5914	T5915	advmod	most,apparent
R4091	T5915	T5913	acomp	apparent,is
R4092	T5916	T5913	prep	in,is
R4093	T5917	T5918	det	the,region
R4094	T5918	T5916	pobj	region,in
R4095	T5919	T5918	amod	midflank,region
R4096	T5920	T5913	prep	within,is
R4097	T5921	T5922	det	the,dermis
R4098	T5922	T5920	pobj	dermis,within
R4099	T5923	T5922	amod	upper,dermis
R4100	T5924	T5922	cc	and,dermis
R4101	T5925	T5926	amod	dermal,cells
R4102	T5926	T5922	conj	cells,dermis
R4103	T5927	T5926	compound	papillae,cells
R4104	T5928	T5929	punct	(,Figure
R4105	T5929	T5913	parataxis	Figure,is
R4106	T5930	T5929	nummod	6B,Figure
R4107	T5931	T5929	punct	),Figure
R4108	T5932	T5897	punct	.,extended
R4109	T5934	T5935	advmod	Thus,are
R4110	T5936	T5935	punct	", ",are
R4111	T5937	T5938	mark	while,explained
R4113	T5939	T5940	det	the,phenotype
R4114	T5940	T5938	nsubjpass	phenotype,explained
R4115	T5941	T5940	compound	pigmentation,phenotype
R4116	T5942	T5940	prep	of,phenotype
R4117	T5943	T5944	compound	deH,deH
R4118	T5944	T5946	compound	deH,mice
R4119	T5945	T5944	punct	/,deH
R4120	T5946	T5942	pobj	mice,of
R4121	T5947	T5938	aux	can,explained
R4122	T5948	T5938	auxpass	be,explained
R4123	T5949	T5938	punct	", ",explained
R4124	T5950	T5951	neg	not,surprisingly
R4125	T5951	T5938	advmod	surprisingly,explained
R4126	T5952	T5938	punct	", ",explained
R4127	T5953	T5938	agent	by,explained
R4128	T5954	T5955	amod	dorsal,extension
R4129	T5955	T5953	pobj	extension,by
R4130	T5956	T5955	prep	of,extension
R4131	T5957	T5958	compound	Agouti,expression
R4132	T5958	T5956	pobj	expression,of
R4133	T5959	T5955	prep	after,extension
R4134	T5960	T5959	pobj	birth,after
R4135	T5961	T5935	punct	", ",are
R4136	T5962	T5963	amod	patterned,expression
R4137	T5963	T5935	nsubj	expression,are
R4138	T5964	T5963	prep	of,expression
R4139	T5965	T5964	pobj	Tbx15,of
R4140	T5966	T5965	cc	and,Tbx15
R4141	T5967	T5965	conj	Agouti,Tbx15
R4142	T5968	T5935	acomp	apparent,are
R4143	T5969	T5970	quantmod	some,10
R4144	T5970	T5971	nummod	10,days
R4145	T5971	T5972	npadvmod	days,earlier
R4146	T5972	T5935	advmod	earlier,are
R4147	T5973	T5935	punct	", ",are
R4148	T5974	T5935	prep	between,are
R4149	T5975	T5974	pobj	E12.5,between
R4150	T5976	T5975	cc	and,E12.5
R4151	T5977	T5975	conj	E13.5,E12.5
R4152	T5978	T5935	punct	", ",are
R4153	T5979	T5935	cc	and,are
R4154	T5980	T5981	det	the,effects
R4155	T5981	T5982	nsubjpass	effects,detected
R4156	T5982	T5935	conj	detected,are
R4157	T5983	T5981	prep	of,effects
R4158	T5984	T5985	compound	Tbx15,deficiency
R4159	T5985	T5983	pobj	deficiency,of
R4160	T5986	T5981	prep	on,effects
R4161	T5987	T5986	pobj	expression,on
R4162	T5988	T5987	prep	of,expression
R4163	T5989	T5988	pobj	Agouti,of
R4164	T5990	T5982	aux	can,detected
R4165	T5991	T5982	auxpass	be,detected
R4166	T5992	T5982	prep	by,detected
R4167	T5993	T5992	pobj	E14.5,by
R4168	T5994	T5935	punct	.,are
R4169	T6166	T6165	prep	of,Relationship
R4170	T6167	T6168	amod	Embryonic,Expression
R4171	T6168	T6166	pobj	Expression,of
R4172	T6169	T6168	compound	Tbx15,Expression
R4173	T6170	T6165	prep	to,Relationship
R4174	T6171	T6172	amod	Dorsal,Domains
R4175	T6172	T6170	pobj	Domains,to
R4176	T6173	T6171	cc	and,Dorsal
R4177	T6174	T6171	conj	Ventral,Dorsal
R4178	T6175	T6172	compound	Pigmentation,Domains
R4179	T6177	T6178	det	The,observations
R4180	T6178	T6179	nsubj	observations,are
R4181	T6180	T6178	acl	described,observations
R4182	T6181	T6180	advmod	above,described
R4183	T6182	T6179	acomp	consistent,are
R4184	T6183	T6182	prep	with,consistent
R4185	T6184	T6185	det	a,model
R4186	T6185	T6183	pobj	model,with
R4187	T6186	T6187	prep	in,required
R4188	T6187	T6185	relcl	required,model
R4189	T6188	T6186	pobj	which,in
R4190	T6189	T6190	amod	transient,expression
R4191	T6190	T6187	nsubjpass	expression,required
R4192	T6191	T6190	prep	of,expression
R4193	T6192	T6191	pobj	Tbx15,of
R4194	T6193	T6190	prep	in,expression
R4195	T6194	T6195	det	the,flank
R4196	T6195	T6193	pobj	flank,in
R4197	T6196	T6195	amod	embryonic,flank
R4198	T6197	T6195	amod	dorsal,flank
R4199	T6198	T6187	auxpass	is,required
R4200	T6199	T6200	aux	to,establish
R4201	T6200	T6187	advcl	establish,required
R4202	T6201	T6202	amod	positional,identity
R4203	T6202	T6200	dobj	identity,establish
R4204	T6203	T6202	prep	of,identity
R4205	T6204	T6205	det	the,dermis
R4206	T6205	T6203	pobj	dermis,of
R4207	T6206	T6205	amod	future,dermis
R4208	T6207	T6200	punct	", ",establish
R4209	T6208	T6209	advmod	at,least
R4210	T6209	T6210	advmod	least,with
R4211	T6210	T6200	prep	with,establish
R4212	T6211	T6210	pobj	respect,with
R4213	T6212	T6211	prep	to,respect
R4214	T6213	T6214	compound	pigment,type
R4215	T6214	T6216	compound	type,synthesis
R4216	T6215	T6214	punct	-,type
R4217	T6216	T6212	pobj	synthesis,to
R4218	T6217	T6216	acl	caused,synthesis
R4219	T6218	T6217	agent	by,caused
R4220	T6219	T6220	det	the,isoform
R4221	T6220	T6218	pobj	isoform,by
R4222	T6221	T6222	amod	ventral,specific
R4223	T6222	T6220	amod	specific,isoform
R4224	T6223	T6222	punct	-,specific
R4225	T6224	T6220	compound	Agouti,isoform
R4226	T6225	T6179	punct	.,are
R4227	T6227	T6228	aux	To,investigate
R4228	T6228	T6230	advcl	investigate,carried
R4229	T6229	T6228	advmod	further,investigate
R4230	T6231	T6232	det	this,hypothesis
R4231	T6232	T6228	dobj	hypothesis,investigate
R4232	T6233	T6230	punct	", ",carried
R4233	T6234	T6230	nsubj	we,carried
R4234	T6235	T6230	prt	out,carried
R4235	T6236	T6237	compound	transplantation,experiments
R4236	T6237	T6230	dobj	experiments,carried
R4237	T6238	T6239	prep	in,isolated
R4238	T6239	T6237	relcl	isolated,experiments
R4239	T6240	T6238	pobj	which,in
R4240	T6241	T6239	nsubjpass	pieces,isolated
R4241	T6242	T6241	prep	of,pieces
R4242	T6243	T6244	amod	embryonic,skin
R4243	T6244	T6242	pobj	skin,of
R4244	T6245	T6239	auxpass	were,isolated
R4245	T6246	T6239	prep	from,isolated
R4246	T6247	T6248	amod	different,positions
R4247	T6248	T6246	pobj	positions,from
R4248	T6249	T6248	amod	dorsoventral,positions
R4249	T6250	T6230	punct	.,carried
R4250	T6252	T6253	nsubj	We,evaluated
R4251	T6254	T6255	det	the,fragments
R4252	T6255	T6253	dobj	fragments,evaluated
R4253	T6256	T6255	amod	embryonic,fragments
R4254	T6257	T6255	compound	skin,fragments
R4255	T6258	T6253	prep	for,evaluated
R4256	T6259	T6260	poss	their,potential
R4257	T6260	T6258	pobj	potential,for
R4258	T6261	T6262	aux	to,give
R4259	T6262	T6260	acl	give,potential
R4260	T6263	T6262	dobj	rise,give
R4261	T6264	T6262	prep	to,give
R4262	T6265	T6266	amod	different,colors
R4263	T6266	T6264	pobj	colors,to
R4264	T6267	T6266	compound	hair,colors
R4265	T6268	T6258	cc	and,for
R4266	T6269	T6258	conj	for,for
R4267	T6270	T6271	poss	their,expression
R4268	T6271	T6269	pobj	expression,for
R4269	T6272	T6271	prep	of,expression
R4270	T6273	T6272	pobj	Tbx15,of
R4271	T6274	T6273	cc	and,Tbx15
R4272	T6275	T6273	conj	Agouti,Tbx15
R4273	T6276	T6253	punct	.,evaluated
R4274	T6278	T6279	amod	Previous,studies
R4275	T6279	T6280	nsubj	studies,showed
R4276	T6281	T6279	prep	by,studies
R4277	T6282	T6281	pobj	Silvers,by
R4278	T6283	T6282	cc	and,Silvers
R4279	T6284	T6282	conj	colleagues,Silvers
R4280	T6285	T6286	punct	(,Poole
R4281	T6286	T6279	meta	Poole,studies
R4282	T6287	T6286	cc	and,Poole
R4283	T6288	T6286	conj	Silvers,Poole
R4284	T6289	T6288	nummod	1976,Silvers
R4285	T6290	T6288	punct	),Silvers
R4286	T6291	T6292	mark	that,gives
R4288	T6293	T6294	amod	dorsal,skin
R4289	T6294	T6292	nsubj	skin,gives
R4290	T6295	T6293	cc	and,dorsal
R4291	T6296	T6293	conj	ventral,dorsal
R4292	T6297	T6294	acl	isolated,skin
R4293	T6298	T6297	prep	from,isolated
R4294	T6299	T6300	compound	at,at
R4295	T6300	T6302	compound	at,embryos
R4296	T6301	T6300	punct	/,at
R4297	T6302	T6298	pobj	embryos,from
R4298	T6303	T6292	dobj	rise,gives
R4299	T6304	T6292	prep	to,gives
R4300	T6305	T6306	amod	black,hair
R4301	T6306	T6304	pobj	hair,to
R4302	T6307	T6305	cc	and,black
R4303	T6308	T6305	conj	yellow,black
R4304	T6309	T6292	punct	", ",gives
R4305	T6310	T6292	advmod	respectively,gives
R4306	T6311	T6292	punct	", ",gives
R4307	T6312	T6313	advmod	when,transplanted
R4308	T6313	T6292	advcl	transplanted,gives
R4309	T6314	T6313	prep	into,transplanted
R4310	T6315	T6314	pobj	testis,into
R4311	T6316	T6313	cc	and,transplanted
R4312	T6317	T6313	conj	allowed,transplanted
R4313	T6318	T6319	aux	to,develop
R4314	T6319	T6317	xcomp	develop,allowed
R4315	T6320	T6319	prep	for,develop
R4316	T6321	T6322	amod	several,weeks
R4317	T6322	T6320	pobj	weeks,for
R4318	T6323	T6280	punct	.,showed
R4319	T6325	T6326	advmod	Furthermore,demonstrated
R4320	T6327	T6326	punct	", ",demonstrated
R4321	T6328	T6329	amod	dermal,epidermal
R4322	T6329	T6331	amod	epidermal,experiments
R4323	T6330	T6329	punct	–,epidermal
R4324	T6331	T6326	nsubj	experiments,demonstrated
R4325	T6332	T6331	compound	recombination,experiments
R4326	T6333	T6331	acl	carried,experiments
R4327	T6334	T6333	prt	out,carried
R4328	T6335	T6333	prep	at,carried
R4329	T6336	T6335	pobj	E14.5,at
R4330	T6337	T6338	mark	that,carried
R4331	T6338	T6326	ccomp	carried,demonstrated
R4332	T6339	T6340	amod	positional,identity
R4333	T6340	T6338	nsubjpass	identity,carried
R4334	T6341	T6338	auxpass	is,carried
R4335	T6342	T6338	agent	by,carried
R4336	T6343	T6344	det	the,dermis
R4337	T6344	T6342	pobj	dermis,by
R4338	T6345	T6344	amod	embryonic,dermis
R4339	T6346	T6326	punct	.,demonstrated
R4340	T6348	T6349	prep	In,divided
R4341	T6350	T6351	det	a,variation
R4342	T6351	T6348	pobj	variation,In
R4343	T6352	T6351	prep	on,variation
R4344	T6353	T6354	det	this,experiment
R4345	T6354	T6352	pobj	experiment,on
R4346	T6355	T6349	punct	", ",divided
R4347	T6356	T6349	nsubj	we,divided
R4348	T6357	T6358	amod	embryonic,skin
R4349	T6358	T6349	dobj	skin,divided
R4350	T6359	T6358	prep	from,skin
R4351	T6360	T6361	compound	at,a
R4352	T6361	T6363	compound	a,embryos
R4353	T6362	T6361	punct	/,a
R4354	T6363	T6359	pobj	embryos,from
R4355	T6364	T6349	prep	into,divided
R4356	T6365	T6366	amod	dorsal,pieces
R4357	T6366	T6364	pobj	pieces,into
R4358	T6367	T6365	punct	", ",dorsal
R4359	T6368	T6365	conj	flank,dorsal
R4360	T6369	T6368	punct	", ",flank
R4361	T6370	T6368	cc	and,flank
R4362	T6371	T6368	conj	ventral,flank
R4363	T6372	T6349	cc	and,divided
R4364	T6373	T6349	conj	analyzed,divided
R4365	T6374	T6375	det	the,pieces
R4366	T6375	T6373	dobj	pieces,analyzed
R4367	T6376	T6375	amod	different,pieces
R4368	T6377	T6373	prep	for,analyzed
R4369	T6378	T6379	poss	their,ability
R4370	T6379	T6377	pobj	ability,for
R4371	T6380	T6381	aux	to,give
R4372	T6381	T6379	acl	give,ability
R4373	T6382	T6381	dobj	rise,give
R4374	T6383	T6381	prep	to,give
R4375	T6384	T6385	amod	black,hair
R4376	T6385	T6383	pobj	hair,to
R4377	T6386	T6384	cc	or,black
R4378	T6387	T6384	conj	yellow,black
R4379	T6388	T6381	prep	after,give
R4380	T6389	T6390	compound	testis,transplantation
R4381	T6390	T6388	pobj	transplantation,after
R4382	T6391	T6377	punct	", ",for
R4383	T6392	T6377	cc	and,for
R4384	T6393	T6394	punct	", ",for
R4385	T6394	T6377	conj	for,for
R4386	T6395	T6394	prep	in,for
R4387	T6396	T6395	pobj	parallel,in
R4388	T6397	T6394	punct	", ",for
R4389	T6398	T6399	compound	gene,expression
R4390	T6399	T6394	pobj	expression,for
R4391	T6400	T6373	advcl	using,analyzed
R4392	T6401	T6402	advmod	in,situ
R4393	T6402	T6403	amod	situ,hybridization
R4394	T6403	T6400	dobj	hybridization,using
R4395	T6404	T6349	punct	.,divided
R4396	T6406	T6407	prep	For,divided
R4397	T6408	T6409	det	the,purposes
R4398	T6409	T6406	pobj	purposes,For
R4399	T6410	T6409	prep	of,purposes
R4400	T6411	T6412	det	a,boundary
R4401	T6412	T6410	pobj	boundary,of
R4402	T6413	T6412	amod	reproducible,boundary
R4403	T6414	T6412	amod	morphologic,boundary
R4404	T6415	T6407	punct	", ",divided
R4405	T6416	T6407	nsubj	we,divided
R4406	T6417	T6407	dobj	flank,divided
R4407	T6418	T6417	prep	from,flank
R4408	T6419	T6418	pobj	ventral,from
R4409	T6420	T6417	appos	skin,flank
R4410	T6421	T6407	prep	based,divided
R4411	T6422	T6421	prep	on,based
R4412	T6423	T6424	det	a,change
R4413	T6424	T6422	pobj	change,on
R4414	T6425	T6424	prep	in,change
R4415	T6426	T6427	compound	skin,thickness
R4416	T6427	T6425	pobj	thickness,in
R4417	T6428	T6407	cc	and,divided
R4418	T6429	T6407	conj	divided,divided
R4419	T6430	T6429	dobj	dorsal,divided
R4420	T6431	T6430	prep	from,dorsal
R4421	T6432	T6431	pobj	flank,from
R4422	T6433	T6430	appos	skin,dorsal
R4423	T6434	T6429	prep	at,divided
R4424	T6435	T6436	det	the,level
R4425	T6436	T6434	pobj	level,at
R4426	T6437	T6436	prep	of,level
R4427	T6438	T6439	det	an,notch
R4428	T6439	T6437	pobj	notch,of
R4429	T6440	T6439	amod	ectodermal,notch
R4430	T6441	T6442	dep	that,lies
R4431	T6442	T6439	relcl	lies,notch
R4432	T6443	T6442	prep	at,lies
R4433	T6444	T6445	det	the,level
R4434	T6445	T6443	pobj	level,at
R4435	T6446	T6445	amod	same,level
R4436	T6447	T6445	prep	as,level
R4437	T6448	T6449	det	the,extent
R4438	T6449	T6447	pobj	extent,as
R4439	T6450	T6449	amod	ventral,extent
R4440	T6451	T6449	prep	of,extent
R4441	T6452	T6453	det	the,myotome
R4442	T6453	T6451	pobj	myotome,of
R4443	T6454	T6455	punct	(,Figure
R4444	T6455	T6429	parataxis	Figure,divided
R4445	T6456	T6455	nummod	7,Figure
R4446	T6457	T6455	punct	),Figure
R4447	T6458	T6459	punct	(,Huang
R4448	T6459	T6429	meta	Huang,divided
R4449	T6460	T6459	cc	and,Huang
R4450	T6461	T6459	conj	Christ,Huang
R4451	T6462	T6461	nummod	2000,Christ
R4452	T6463	T6461	punct	;,Christ
R4453	T6464	T6461	conj	Olivera,Christ
R4454	T6465	T6464	punct	-,Olivera
R4455	T6466	T6464	nmod	Martinez,Olivera
R4456	T6467	T6464	nmod	et,Olivera
R4457	T6468	T6464	nmod	al.,Olivera
R4458	T6469	T6464	nummod	2000,Olivera
R4459	T6470	T6464	punct	;,Olivera
R4460	T6471	T6464	conj	Sudo,Olivera
R4461	T6472	T6471	nmod	et,Sudo
R4462	T6473	T6471	nmod	al.,Sudo
R4463	T6474	T6471	nummod	2001,Sudo
R4464	T6475	T6471	punct	;,Sudo
R4465	T6476	T6471	conj	Burke,Sudo
R4466	T6477	T6476	cc	and,Burke
R4467	T6478	T6476	conj	Nowicki,Burke
R4468	T6479	T6478	nummod	2003,Nowicki
R4469	T6480	T6478	punct	;,Nowicki
R4470	T6481	T6478	conj	Nowicki,Nowicki
R4471	T6482	T6481	nmod	et,Nowicki
R4472	T6483	T6481	nmod	al.,Nowicki
R4473	T6484	T6481	nummod	2003,Nowicki
R4474	T6485	T6481	punct	),Nowicki
R4475	T6486	T6407	punct	.,divided
R4476	T6488	T6489	nsubj	We,found
R4477	T6490	T6491	mark	that,is
R4478	T6491	T6489	ccomp	is,found
R4479	T6492	T6491	nsubj	E12.5,is
R4480	T6493	T6494	det	the,time
R4481	T6494	T6491	attr	time,is
R4482	T6495	T6494	amod	earliest,time
R4483	T6496	T6497	prep	at,is
R4484	T6497	T6494	relcl	is,time
R4485	T6498	T6496	pobj	which,at
R4486	T6499	T6500	amod	embryonic,skin
R4487	T6500	T6497	nsubj	skin,is
R4488	T6501	T6500	amod	ventral,skin
R4489	T6502	T6497	acomp	able,is
R4490	T6503	T6504	aux	to,produce
R4491	T6504	T6502	xcomp	produce,able
R4492	T6505	T6504	dobj	hair,produce
R4493	T6506	T6507	advmod	when,transplanted
R4494	T6507	T6504	advcl	transplanted,produce
R4495	T6508	T6507	prep	to,transplanted
R4496	T6509	T6510	det	the,testis
R4497	T6510	T6508	pobj	testis,to
R4498	T6511	T6489	punct	.,found
R4499	T6513	T6514	prep	Of,gave
R4500	T6515	T6516	det	the,grafts
R4501	T6516	T6513	pobj	grafts,Of
R4502	T6517	T6518	dep	that,produced
R4503	T6518	T6516	relcl	produced,grafts
R4504	T6519	T6518	dobj	hair,produced
R4505	T6520	T6514	punct	", ",gave
R4506	T6521	T6522	amod	ventral,skin
R4507	T6522	T6514	nsubj	skin,gave
R4508	T6523	T6514	dobj	rise,gave
R4509	T6524	T6514	prep	to,gave
R4510	T6525	T6526	amod	yellow,hair
R4511	T6526	T6524	pobj	hair,to
R4512	T6527	T6528	punct	(,3
R4513	T6528	T6514	parataxis	3,gave
R4514	T6529	T6528	nsubj	n,3
R4515	T6530	T6528	punct	=,3
R4516	T6531	T6528	punct	),3
R4517	T6532	T6514	punct	", ",gave
R4518	T6533	T6514	cc	and,gave
R4519	T6534	T6535	amod	dorsal,skin
R4520	T6535	T6536	nsubj	skin,gave
R4521	T6536	T6514	conj	gave,gave
R4522	T6537	T6536	dobj	rise,gave
R4523	T6538	T6536	prep	to,gave
R4524	T6539	T6540	amod	black,hair
R4525	T6540	T6538	pobj	hair,to
R4526	T6541	T6542	punct	(,4
R4527	T6542	T6536	parataxis	4,gave
R4528	T6543	T6542	nsubj	n,4
R4529	T6544	T6542	punct	=,4
R4530	T6545	T6542	punct	),4
R4531	T6546	T6514	punct	.,gave
R4532	T6548	T6549	nsubj	Transplantation,gave
R4533	T6549	T6553	ccomp	gave,produced
R4534	T6550	T6548	prep	of,Transplantation
R4535	T6551	T6552	compound	flank,skin
R4536	T6552	T6550	pobj	skin,of
R4537	T6554	T6549	dobj	rise,gave
R4538	T6555	T6549	prep	to,gave
R4539	T6556	T6557	det	a,patch
R4540	T6557	T6555	pobj	patch,to
R4541	T6558	T6557	prep	of,patch
R4542	T6559	T6560	amod	yellow,hair
R4543	T6560	T6558	pobj	hair,of
R4544	T6561	T6557	acl	juxtaposed,patch
R4545	T6562	T6561	prep	against,juxtaposed
R4546	T6563	T6564	det	a,patch
R4547	T6564	T6562	pobj	patch,against
R4548	T6565	T6564	prep	of,patch
R4549	T6566	T6567	amod	black,hair
R4550	T6567	T6565	pobj	hair,of
R4551	T6568	T6549	prep	in,gave
R4552	T6569	T6570	nummod	85,%
R4553	T6570	T6568	pobj	%,in
R4554	T6571	T6570	prep	of,%
R4555	T6572	T6573	det	the,grafts
R4556	T6573	T6571	pobj	grafts,of
R4557	T6574	T6573	amod	successful,grafts
R4558	T6575	T6576	punct	(,13
R4559	T6576	T6549	parataxis	13,gave
R4560	T6577	T6576	nsubj	n,13
R4561	T6578	T6576	punct	=,13
R4562	T6579	T6576	punct	),13
R4563	T6580	T6553	punct	;,produced
R4564	T6581	T6582	det	the,grafts
R4565	T6582	T6553	nsubj	grafts,produced
R4566	T6583	T6582	amod	remaining,grafts
R4567	T6584	T6582	nummod	two,grafts
R4568	T6585	T6582	compound	flank,grafts
R4569	T6586	T6587	advmod	solely,black
R4570	T6587	T6588	amod	black,hair
R4571	T6588	T6553	dobj	hair,produced
R4572	T6589	T6587	cc	or,black
R4573	T6590	T6587	conj	yellow,black
R4574	T6591	T6553	punct	.,produced
R4575	T6593	T6594	prep	In,observe
R4576	T6595	T6596	det	no,case
R4577	T6596	T6593	pobj	case,In
R4578	T6597	T6594	aux	did,observe
R4579	T6598	T6594	nsubj	we,observe
R4580	T6599	T6594	dobj	intermingling,observe
R4581	T6600	T6599	prep	of,intermingling
R4582	T6601	T6602	amod	black,hairs
R4583	T6602	T6600	pobj	hairs,of
R4584	T6603	T6601	cc	and,black
R4585	T6604	T6601	conj	yellow,black
R4586	T6605	T6594	punct	.,observe
R4587	T6607	T6608	mark	As,predicted
R4588	T6608	T6609	advcl	predicted,expressed
R4589	T6610	T6608	prep	from,predicted
R4590	T6611	T6612	det	the,experiments
R4591	T6612	T6610	pobj	experiments,from
R4592	T6613	T6612	acl	using,experiments
R4593	T6614	T6615	compound	tissue,sections
R4594	T6615	T6613	dobj	sections,using
R4595	T6616	T6617	punct	(,see
R4596	T6617	T6608	parataxis	see,predicted
R4597	T6618	T6619	nmod	Figures,5
R4598	T6619	T6617	dobj	5,see
R4599	T6620	T6619	cc	and,5
R4600	T6621	T6619	conj	6,5
R4601	T6622	T6617	punct	),see
R4602	T6623	T6609	punct	", ",expressed
R4603	T6624	T6625	amod	dorsal,pieces
R4604	T6625	T6609	nsubj	pieces,expressed
R4605	T6626	T6609	dobj	Tbx15,expressed
R4606	T6627	T6626	cc	but,Tbx15
R4607	T6628	T6627	neg	not,but
R4608	T6629	T6626	conj	Agouti,Tbx15
R4609	T6630	T6609	punct	", ",expressed
R4610	T6631	T6632	mark	while,expressed
R4611	T6632	T6609	advcl	expressed,expressed
R4612	T6633	T6634	compound	flank,pieces
R4613	T6634	T6632	nsubj	pieces,expressed
R4614	T6635	T6636	det	both,genes
R4615	T6636	T6632	dobj	genes,expressed
R4616	T6637	T6638	punct	(,see
R4617	T6638	T6609	parataxis	see,expressed
R4618	T6639	T6638	dobj	Figure,see
R4619	T6640	T6639	nummod	7,Figure
R4620	T6641	T6638	punct	),see
R4621	T6642	T6609	punct	.,expressed
R4622	T6644	T6645	advmod	Thus,established
R4623	T6645	T6653	ccomp	established,maintained
R4624	T6646	T6645	punct	", ",established
R4625	T6647	T6648	amod	dorsoventral,identity
R4626	T6648	T6645	nsubjpass	identity,established
R4627	T6649	T6648	prep	for,identity
R4628	T6650	T6651	amod	adult,pigmentation
R4629	T6651	T6649	pobj	pigmentation,for
R4630	T6652	T6645	auxpass	is,established
R4631	T6654	T6645	prep	by,established
R4632	T6655	T6656	det	the,time
R4633	T6656	T6654	pobj	time,by
R4634	T6657	T6658	advmod	when,becomes
R4635	T6658	T6656	relcl	becomes,time
R4636	T6659	T6660	amod	patterned,expression
R4637	T6660	T6658	nsubj	expression,becomes
R4638	T6661	T6658	acomp	apparent,becomes
R4639	T6662	T6658	prep	for,becomes
R4640	T6663	T6662	pobj	Tbx15,for
R4641	T6664	T6663	cc	and,Tbx15
R4642	T6665	T6663	conj	Agouti,Tbx15
R4643	T6666	T6667	punct	(,E11.5
R4644	T6667	T6658	parataxis	E11.5,becomes
R4645	T6668	T6669	punct	–,E12.5
R4646	T6669	T6667	prep	E12.5,E11.5
R4647	T6670	T6667	punct	),E11.5
R4648	T6671	T6653	punct	;,maintained
R4649	T6672	T6653	advmod	furthermore,maintained
R4650	T6673	T6653	punct	", ",maintained
R4651	T6674	T6675	amod	positional,identity
R4652	T6675	T6653	nsubjpass	identity,maintained
R4653	T6676	T6653	auxpass	is,maintained
R4654	T6677	T6653	prep	throughout,maintained
R4655	T6678	T6679	amod	later,stages
R4656	T6679	T6677	pobj	stages,throughout
R4657	T6680	T6679	prep	of,stages
R4658	T6681	T6682	compound	skin,development
R4659	T6682	T6680	pobj	development,of
R4660	T6683	T6653	punct	", ",maintained
R4661	T6684	T6685	advmod	even,broadens
R4662	T6685	T6653	advcl	broadens,maintained
R4663	T6686	T6685	mark	though,broadens
R4664	T6687	T6685	nsubj	expression,broadens
R4665	T6688	T6687	prep	of,expression
R4666	T6689	T6688	pobj	Tbx15,of
R4667	T6690	T6691	aux	to,include
R4668	T6691	T6685	advcl	include,broadens
R4669	T6692	T6693	amod	ventral,skin
R4670	T6693	T6691	dobj	skin,include
R4671	T6694	T6695	advmod	as,as
R4672	T6695	T6692	cc	as,ventral
R4673	T6696	T6695	advmod	well,as
R4674	T6697	T6692	conj	dorsal,ventral
R4675	T6698	T6653	punct	.,maintained
R4676	T6884	T6883	prep	of,Relationship
R4677	T6885	T6886	det	the,Boundary
R4678	T6886	T6884	pobj	Boundary,of
R4679	T6887	T6886	amod	Dorsoventral,Boundary
R4680	T6888	T6886	compound	Pigment,Boundary
R4681	T6889	T6883	prep	to,Relationship
R4682	T6890	T6891	compound	Lineage,Compartments
R4683	T6891	T6889	pobj	Compartments,to
R4684	T6892	T6891	cc	and,Compartments
R4685	T6893	T6894	det	the,Frontier
R4686	T6894	T6891	conj	Frontier,Compartments
R4687	T6895	T6894	amod	Lateral,Frontier
R4688	T6896	T6894	amod	Somitic,Frontier
R4689	T6898	T6899	det	The,notch
R4690	T6899	T6901	nsubj	notch,is
R4691	T6900	T6899	amod	ectodermal,notch
R4692	T6902	T6903	dep	that,used
R4693	T6903	T6899	relcl	used,notch
R4694	T6904	T6903	nsubj	we,used
R4695	T6905	T6906	aux	to,mark
R4696	T6906	T6903	advcl	mark,used
R4697	T6907	T6908	det	the,boundary
R4698	T6908	T6906	dobj	boundary,mark
R4699	T6909	T6908	prep	between,boundary
R4700	T6910	T6911	amod	embryonic,dorsum
R4701	T6911	T6909	pobj	dorsum,between
R4702	T6912	T6911	cc	and,dorsum
R4703	T6913	T6914	amod	embryonic,flank
R4704	T6914	T6911	conj	flank,dorsum
R4705	T6915	T6916	det	a,feature
R4706	T6916	T6901	attr	feature,is
R4707	T6917	T6916	amod	characteristic,feature
R4708	T6918	T6901	prep	in,is
R4709	T6919	T6920	compound	vertebrate,embryos
R4710	T6920	T6918	pobj	embryos,in
R4711	T6921	T6901	punct	.,is
R4712	T6923	T6924	prep	In,serves
R4713	T6925	T6926	compound	cell,studies
R4714	T6926	T6923	pobj	studies,In
R4715	T6927	T6926	compound	lineage,studies
R4716	T6928	T6926	acl	carried,studies
R4717	T6929	T6928	prt	out,carried
R4718	T6930	T6928	prep	in,carried
R4719	T6931	T6932	det	the,system
R4720	T6932	T6930	pobj	system,in
R4721	T6933	T6932	compound	chick,system
R4722	T6934	T6924	punct	", ",serves
R4723	T6935	T6936	det	the,notch
R4724	T6936	T6924	nsubj	notch,serves
R4725	T6937	T6924	prep	as,serves
R4726	T6938	T6939	det	a,landmark
R4727	T6939	T6937	pobj	landmark,as
R4728	T6940	T6939	prep	for,landmark
R4729	T6941	T6942	det	the,boundary
R4730	T6942	T6940	pobj	boundary,for
R4731	T6943	T6942	prep	between,boundary
R4732	T6944	T6943	pobj	dermis,between
R4733	T6945	T6944	acl	derived,dermis
R4734	T6946	T6945	prep	from,derived
R4735	T6947	T6948	amod	somitic,mesoderm
R4736	T6948	T6946	pobj	mesoderm,from
R4737	T6949	T6944	cc	and,dermis
R4738	T6950	T6944	conj	dermis,dermis
R4739	T6951	T6950	acl	derived,dermis
R4740	T6952	T6951	prep	from,derived
R4741	T6953	T6954	amod	lateral,plate
R4742	T6954	T6955	compound	plate,mesoderm
R4743	T6955	T6952	pobj	mesoderm,from
R4744	T6956	T6924	cc	and,serves
R4745	T6957	T6958	aux	has,termed
R4746	T6958	T6924	conj	termed,serves
R4747	T6959	T6958	auxpass	been,termed
R4748	T6960	T6961	det	the,frontier
R4749	T6961	T6958	oprd	frontier,termed
R4750	T6962	T6961	punct	“,frontier
R4751	T6963	T6961	amod	lateral,frontier
R4752	T6964	T6961	amod	somitic,frontier
R4753	T6965	T6958	punct	”,termed
R4754	T6966	T6967	punct	(,Olivera
R4755	T6967	T6958	meta	Olivera,termed
R4756	T6968	T6967	punct	-,Olivera
R4757	T6969	T6967	nmod	Martinez,Olivera
R4758	T6970	T6967	nmod	et,Olivera
R4759	T6971	T6967	nmod	al.,Olivera
R4760	T6972	T6967	nummod	2000,Olivera
R4761	T6973	T6967	punct	;,Olivera
R4762	T6974	T6967	conj	Sudo,Olivera
R4763	T6975	T6974	nmod	et,Sudo
R4764	T6976	T6974	nmod	al.,Sudo
R4765	T6977	T6974	nummod	2001,Sudo
R4766	T6978	T6974	punct	;,Sudo
R4767	T6979	T6974	conj	Burke,Sudo
R4768	T6980	T6979	cc	and,Burke
R4769	T6981	T6979	conj	Nowicki,Burke
R4770	T6982	T6981	nummod	2003,Nowicki
R4771	T6983	T6981	punct	;,Nowicki
R4772	T6984	T6981	conj	Nowicki,Nowicki
R4773	T6985	T6984	nmod	et,Nowicki
R4774	T6986	T6984	nmod	al.,Nowicki
R4775	T6987	T6984	nummod	2003,Nowicki
R4776	T6988	T6984	punct	),Nowicki
R4777	T6989	T6924	punct	.,serves
R4778	T6991	T6992	mark	Although,carried
R4779	T6992	T7000	advcl	carried,give
R4780	T6993	T6994	npadvmod	fate,mapping
R4781	T6994	T6996	amod	mapping,studies
R4782	T6995	T6994	punct	-,mapping
R4783	T6996	T6992	nsubjpass	studies,carried
R4784	T6997	T6992	aux	have,carried
R4785	T6998	T6992	neg	not,carried
R4786	T6999	T6992	auxpass	been,carried
R4787	T7001	T6992	prt	out,carried
R4788	T7002	T6992	prep	in,carried
R4789	T7003	T7004	amod	mammalian,embryos
R4790	T7004	T7002	pobj	embryos,in
R4791	T7005	T7000	punct	", ",give
R4792	T7006	T7007	npadvmod	somite,derived
R4793	T7007	T7013	amod	derived,mesoderm
R4794	T7008	T7006	punct	-,somite
R4795	T7009	T7006	cc	and,somite
R4796	T7010	T7011	amod	lateral,plate
R4797	T7011	T7006	conj	plate,somite
R4798	T7012	T7007	punct	-,derived
R4799	T7013	T7000	nsubj	mesoderm,give
R4800	T7014	T7000	aux	could,give
R4801	T7015	T7000	dobj	rise,give
R4802	T7016	T7000	prep	to,give
R4803	T7017	T7016	pobj	precursors,to
R4804	T7018	T7000	prep	for,give
R4805	T7019	T7018	pobj	dermis,for
R4806	T7020	T7019	amod	dorsal,dermis
R4807	T7021	T7020	cc	and,dorsal
R4808	T7022	T7020	conj	ventral,dorsal
R4809	T7023	T7022	prep	to,ventral
R4810	T7024	T7025	det	the,junction
R4811	T7025	T7023	pobj	junction,to
R4812	T7026	T7025	nmod	limb,junction
R4813	T7027	T7026	punct	–,limb
R4814	T7028	T7029	compound	body,wall
R4815	T7029	T7026	appos	wall,limb
R4816	T7030	T7000	punct	", ",give
R4817	T7031	T7000	advmod	respectively,give
R4818	T7032	T7000	punct	.,give
R4819	T7034	T7035	advmod	However,conflicts
R4820	T7036	T7035	punct	", ",conflicts
R4821	T7037	T7038	det	this,notion
R4822	T7038	T7035	nsubj	notion,conflicts
R4823	T7039	T7035	prep	with,conflicts
R4824	T7040	T7041	poss	our,observation
R4825	T7041	T7039	pobj	observation,with
R4826	T7042	T7043	mark	that,lies
R4827	T7043	T7041	acl	lies,observation
R4828	T7044	T7045	det	the,boundary
R4829	T7045	T7043	nsubj	boundary,lies
R4830	T7046	T7045	amod	future,boundary
R4831	T7047	T7045	compound	pigmentation,boundary
R4832	T7048	T7043	advmod	ventral,lies
R4833	T7049	T7048	prep	to,ventral
R4834	T7050	T7051	det	the,notch
R4835	T7051	T7049	pobj	notch,to
R4836	T7052	T7051	amod	ectodermal,notch
R4837	T7053	T7054	punct	(,see
R4838	T7054	T7041	parataxis	see,observation
R4839	T7055	T7054	dobj	Figure,see
R4840	T7056	T7055	nummod	7,Figure
R4841	T7057	T7054	punct	),see
R4842	T7058	T7035	punct	.,conflicts
R4843	T7060	T7061	aux	To,examine
R4844	T7061	T7062	advcl	examine,made
R4845	T7063	T7061	advmod	directly,examine
R4846	T7064	T7065	det	the,relationship
R4847	T7065	T7061	dobj	relationship,examine
R4848	T7066	T7065	prep	between,relationship
R4849	T7067	T7068	det	the,boundary
R4850	T7068	T7066	pobj	boundary,between
R4851	T7069	T7068	compound	pigmentation,boundary
R4852	T7070	T7068	cc	and,boundary
R4853	T7071	T7068	conj	dermis,boundary
R4854	T7072	T7071	acl	derived,dermis
R4855	T7073	T7072	prep	from,derived
R4856	T7074	T7075	amod	lateral,plate
R4857	T7075	T7076	compound	plate,mesoderm
R4858	T7076	T7073	pobj	mesoderm,from
R4859	T7077	T7062	punct	", ",made
R4860	T7078	T7062	nsubj	we,made
R4861	T7079	T7062	dobj	use,made
R4862	T7080	T7062	prep	of,made
R4863	T7081	T7082	det	a,transgene
R4864	T7082	T7080	pobj	transgene,of
R4865	T7083	T7082	compound	Cre,transgene
R4866	T7084	T7082	acl	driven,transgene
R4867	T7085	T7084	agent	by,driven
R4868	T7086	T7087	det	the,promoter
R4869	T7087	T7085	pobj	promoter,by
R4870	T7088	T7087	compound	Hoxb6,promoter
R4871	T7089	T7090	dep	that,developed
R4872	T7090	T7087	relcl	developed,promoter
R4873	T7091	T7090	auxpass	was,developed
R4874	T7092	T7090	agent	by,developed
R4875	T7093	T7092	pobj	Kuehn,by
R4876	T7094	T7093	cc	and,Kuehn
R4877	T7095	T7093	conj	colleagues,Kuehn
R4878	T7096	T7097	punct	(,Lowe
R4879	T7097	T7062	meta	Lowe,made
R4880	T7098	T7097	nmod	et,Lowe
R4881	T7099	T7097	nmod	al.,Lowe
R4882	T7100	T7097	nummod	2000,Lowe
R4883	T7101	T7097	punct	),Lowe
R4884	T7102	T7062	punct	.,made
R4885	T7104	T7105	mark	As,described
R4886	T7105	T7106	advcl	described,exhibit
R4887	T7107	T7105	agent	by,described
R4888	T7108	T7107	pobj	Lowe,by
R4889	T7109	T7110	advmod	et,al.
R4890	T7110	T7108	advmod	al.,Lowe
R4891	T7111	T7108	punct	(,Lowe
R4892	T7112	T7108	npadvmod	2000,Lowe
R4893	T7113	T7108	punct	),Lowe
R4894	T7114	T7106	punct	", ",exhibit
R4895	T7115	T7116	compound	midgestation,embryos
R4896	T7116	T7106	nsubj	embryos,exhibit
R4897	T7117	T7116	acl	carrying,embryos
R4898	T7118	T7119	preconj	both,transgene
R4899	T7119	T7117	dobj	transgene,carrying
R4900	T7120	T7119	det	the,transgene
R4901	T7121	T7122	compound	Hoxb6,Cre
R4902	T7122	T7119	compound	Cre,transgene
R4903	T7123	T7122	punct	-,Cre
R4904	T7124	T7119	cc	and,transgene
R4905	T7125	T7126	det	the,gene
R4906	T7126	T7119	conj	gene,transgene
R4907	T7127	T7126	compound	R26R,gene
R4908	T7128	T7126	compound	lacZ,gene
R4909	T7129	T7126	compound	reporter,gene
R4910	T7130	T7131	punct	(,Soriano
R4911	T7131	T7126	meta	Soriano,gene
R4912	T7132	T7131	nummod	1999,Soriano
R4913	T7133	T7131	punct	),Soriano
R4914	T7134	T7135	compound	X,Gal
R4915	T7135	T7137	compound	Gal,staining
R4916	T7136	T7135	punct	-,Gal
R4917	T7137	T7106	dobj	staining,exhibit
R4918	T7138	T7106	prep	in,exhibit
R4919	T7139	T7140	amod	lateral,plate
R4920	T7140	T7141	compound	plate,mesoderm
R4921	T7141	T7138	pobj	mesoderm,in
R4922	T7142	T7141	cc	but,mesoderm
R4923	T7143	T7142	neg	not,but
R4924	T7144	T7145	npadvmod	somite,derived
R4925	T7145	T7147	amod	derived,mesoderm
R4926	T7146	T7145	punct	-,derived
R4927	T7147	T7141	conj	mesoderm,mesoderm
R4928	T7148	T7147	prep	of,mesoderm
R4929	T7149	T7150	det	the,trunk
R4930	T7150	T7148	pobj	trunk,of
R4931	T7151	T7106	punct	.,exhibit
R4932	T7153	T7154	prep	In,observed
R4933	T7155	T7156	amod	whole,mount
R4934	T7156	T7158	compound	mount,preparations
R4935	T7157	T7156	punct	-,mount
R4936	T7158	T7153	pobj	preparations,In
R4937	T7159	T7158	compound	skin,preparations
R4938	T7160	T7158	prep	from,preparations
R4939	T7161	T7162	nmod	P1.5,animals
R4940	T7162	T7160	pobj	animals,from
R4941	T7163	T7161	cc	or,P1.5
R4942	T7164	T7161	conj	P4.5,P1.5
R4943	T7165	T7162	amod	neonatal,animals
R4944	T7166	T7154	punct	", ",observed
R4945	T7167	T7154	nsubj	we,observed
R4946	T7168	T7169	det	a,band
R4947	T7169	T7154	dobj	band,observed
R4948	T7170	T7169	amod	ventral,band
R4949	T7171	T7169	prep	of,band
R4950	T7172	T7173	amod	dark,staining
R4951	T7173	T7171	pobj	staining,of
R4952	T7174	T7173	compound	X,staining
R4953	T7175	T7173	punct	-,staining
R4954	T7176	T7173	compound	Gal,staining
R4955	T7177	T7169	acl	corresponding,band
R4956	T7178	T7177	prep	to,corresponding
R4957	T7179	T7180	amod	lateral,plate
R4958	T7180	T7181	npadvmod	plate,derived
R4959	T7181	T7183	amod	derived,dermis
R4960	T7182	T7181	punct	-,derived
R4961	T7183	T7178	pobj	dermis,to
R4962	T7184	T7183	punct	", ",dermis
R4963	T7185	T7186	dep	which,represents
R4964	T7186	T7183	relcl	represents,dermis
R4965	T7187	T7188	nummod	63,%
R4966	T7188	T7186	dobj	%,represents
R4967	T7189	T7188	prep	of,%
R4968	T7190	T7191	det	the,circumference
R4969	T7191	T7189	pobj	circumference,of
R4970	T7192	T7191	amod	total,circumference
R4971	T7193	T7194	punct	(,Figure
R4972	T7194	T7154	parataxis	Figure,observed
R4973	T7195	T7194	nummod	8A,Figure
R4974	T7196	T7194	punct	),Figure
R4975	T7197	T7154	punct	.,observed
R4976	T7199	T7200	advmod	However,represents
R4977	T7200	T7215	ccomp	represents,are
R4978	T7201	T7200	punct	", ",represents
R4979	T7202	T7200	prep	in,represents
R4980	T7203	T7204	amod	parallel,preparations
R4981	T7204	T7202	pobj	preparations,in
R4982	T7205	T7204	prep	from,preparations
R4983	T7206	T7207	compound	at,at
R4984	T7207	T7209	compound	at,mice
R4985	T7208	T7207	punct	/,at
R4986	T7209	T7205	pobj	mice,from
R4987	T7210	T7200	punct	", ",represents
R4988	T7211	T7212	det	the,domain
R4989	T7212	T7200	nsubj	domain,represents
R4990	T7213	T7212	amod	ventral,domain
R4991	T7214	T7212	compound	pheomelanin,domain
R4992	T7216	T7217	nummod	47,%
R4993	T7217	T7200	dobj	%,represents
R4994	T7218	T7217	prep	of,%
R4995	T7219	T7220	det	the,circumference
R4996	T7220	T7218	pobj	circumference,of
R4997	T7221	T7220	amod	total,circumference
R4998	T7222	T7220	compound	skin,circumference
R4999	T7223	T7215	punct	;,are
R5000	T7224	T7215	advmod	therefore,are
R5001	T7225	T7215	punct	", ",are
R5002	T7226	T7227	det	the,proportions
R5003	T7227	T7215	nsubj	proportions,are
R5004	T7228	T7227	prep	of,proportions
R5005	T7229	T7230	amod	total,circumference
R5006	T7230	T7228	pobj	circumference,of
R5007	T7231	T7230	compound	skin,circumference
R5008	T7232	T7230	acl	occupied,circumference
R5009	T7233	T7232	agent	by,occupied
R5010	T7234	T7235	amod	dorsal,eumelanin
R5011	T7235	T7236	nmod	eumelanin,dermis
R5012	T7236	T7233	pobj	dermis,by
R5013	T7237	T7235	cc	and,eumelanin
R5014	T7238	T7239	npadvmod	somite,derived
R5015	T7239	T7235	conj	derived,eumelanin
R5016	T7240	T7239	punct	-,derived
R5017	T7241	T7242	nummod	53,%
R5018	T7242	T7215	attr	%,are
R5019	T7243	T7242	cc	and,%
R5020	T7244	T7245	nummod	37,%
R5021	T7245	T7242	conj	%,%
R5022	T7246	T7215	punct	", ",are
R5023	T7247	T7215	advmod	respectively,are
R5024	T7248	T7249	punct	(,Figure
R5025	T7249	T7215	parataxis	Figure,are
R5026	T7250	T7249	nummod	8B,Figure
R5027	T7251	T7249	punct	),Figure
R5028	T7252	T7215	punct	.,are
R5029	T7254	T7255	det	These,results
R5030	T7255	T7256	nsubj	results,indicate
R5031	T7257	T7258	mark	that,is
R5032	T7258	T7256	ccomp	is,indicate
R5033	T7259	T7260	det	the,boundary
R5034	T7260	T7258	nsubj	boundary,is
R5035	T7261	T7260	compound	pigmentation,boundary
R5036	T7262	T7258	advmod	clearly,is
R5037	T7263	T7258	acomp	distinct,is
R5038	T7264	T7263	prep	from,distinct
R5039	T7265	T7263	punct	", ",distinct
R5040	T7266	T7263	cc	and,distinct
R5041	T7267	T7268	advmod	more,ventral
R5042	T7268	T7263	conj	ventral,distinct
R5043	T7269	T7268	prep	to,ventral
R5044	T7270	T7268	punct	", ",ventral
R5045	T7271	T7272	det	the,boundary
R5046	T7272	T7268	conj	boundary,ventral
R5047	T7273	T7272	prep	between,boundary
R5048	T7274	T7275	amod	lateral,plate
R5049	T7275	T7276	npadvmod	plate,derived
R5050	T7276	T7281	amod	derived,dermis
R5051	T7277	T7275	punct	-,plate
R5052	T7278	T7275	cc	and,plate
R5053	T7279	T7275	conj	somite,plate
R5054	T7280	T7276	punct	-,derived
R5055	T7281	T7273	pobj	dermis,between
R5056	T7282	T7256	punct	.,indicate
R5057	T7284	T7285	mark	Because,lies
R5058	T7285	T7289	advcl	lies,wondered
R5059	T7286	T7287	det	the,boundary
R5060	T7287	T7285	nsubj	boundary,lies
R5061	T7288	T7287	compound	pigmentation,boundary
R5062	T7290	T7285	prep	in,lies
R5063	T7291	T7290	pobj	register,in
R5064	T7292	T7291	prep	with,register
R5065	T7293	T7294	det	the,junction
R5066	T7294	T7292	pobj	junction,with
R5067	T7295	T7294	nmod	limb,junction
R5068	T7296	T7295	punct	–,limb
R5069	T7297	T7298	compound	body,wall
R5070	T7298	T7295	appos	wall,limb
R5071	T7299	T7300	punct	(,see
R5072	T7300	T7285	parataxis	see,lies
R5073	T7301	T7300	dobj	Figure,see
R5074	T7302	T7301	nummod	2,Figure
R5075	T7303	T7300	punct	),see
R5076	T7304	T7289	punct	", ",wondered
R5077	T7305	T7289	nsubj	we,wondered
R5078	T7306	T7307	mark	whether,be
R5079	T7307	T7289	ccomp	be,wondered
R5080	T7308	T7307	nsubj	mechanisms,be
R5081	T7309	T7308	acl	used,mechanisms
R5082	T7310	T7309	prep	for,used
R5083	T7311	T7312	amod	dorsoventral,patterning
R5084	T7312	T7310	pobj	patterning,for
R5085	T7313	T7312	compound	limb,patterning
R5086	T7314	T7307	aux	might,be
R5087	T7315	T7307	acomp	related,be
R5088	T7316	T7315	prep	to,related
R5089	T7317	T7316	pobj	those,to
R5090	T7318	T7317	acl	used,those
R5091	T7319	T7320	aux	to,establish
R5092	T7320	T7318	advcl	establish,used
R5093	T7321	T7322	det	the,boundary
R5094	T7322	T7320	dobj	boundary,establish
R5095	T7323	T7322	compound	pigmentation,boundary
R5096	T7324	T7289	punct	.,wondered
R5097	T7326	T7327	prep	In,are
R5098	T7328	T7329	det	the,limb
R5099	T7329	T7326	pobj	limb,In
R5100	T7330	T7329	amod	developing,limb
R5101	T7331	T7327	punct	", ",are
R5102	T7332	T7327	nsubj	Engrailed1,are
R5103	T7333	T7332	punct	(,Engrailed1
R5104	T7334	T7332	appos	En1,Engrailed1
R5105	T7335	T7332	punct	),Engrailed1
R5106	T7336	T7332	punct	", ",Engrailed1
R5107	T7337	T7332	conj	Wnt7a,Engrailed1
R5108	T7338	T7337	punct	", ",Wnt7a
R5109	T7339	T7337	cc	and,Wnt7a
R5110	T7340	T7337	conj	Lmx1b,Wnt7a
R5111	T7341	T7327	attr	part,are
R5112	T7342	T7341	prep	of,part
R5113	T7343	T7344	det	a,network
R5114	T7344	T7342	pobj	network,of
R5115	T7345	T7346	poss	whose,domains
R5116	T7346	T7348	dep	domains,help
R5117	T7347	T7346	amod	restricted,domains
R5118	T7348	T7344	relcl	help,network
R5119	T7349	T7346	prep	of,domains
R5120	T7350	T7349	pobj	expression,of
R5121	T7351	T7352	aux	to,establish
R5122	T7352	T7348	xcomp	establish,help
R5123	T7353	T7354	amod	dorsoventral,identity
R5124	T7354	T7352	dobj	identity,establish
R5125	T7355	T7356	punct	(,reviewed
R5126	T7356	T7352	parataxis	reviewed,establish
R5127	T7357	T7356	prep	in,reviewed
R5128	T7358	T7357	pobj	Niswander,in
R5129	T7359	T7358	npadvmod	2003,Niswander
R5130	T7360	T7356	punct	),reviewed
R5131	T7361	T7327	punct	.,are
R5132	T7363	T7364	nsubjpass	En1,expressed
R5133	T7364	T7367	ccomp	expressed,reveal
R5134	T7365	T7364	auxpass	is,expressed
R5135	T7366	T7364	advmod	transiently,expressed
R5136	T7368	T7364	prep	in,expressed
R5137	T7369	T7370	det	the,flank
R5138	T7370	T7368	pobj	flank,in
R5139	T7371	T7370	amod	developing,flank
R5140	T7372	T7367	punct	;,reveal
R5141	T7373	T7367	prep	at,reveal
R5142	T7374	T7373	pobj	E11.5,at
R5143	T7375	T7367	punct	", ",reveal
R5144	T7376	T7377	amod	transverse,sections
R5145	T7377	T7367	nsubj	sections,reveal
R5146	T7378	T7377	amod	abdominal,sections
R5147	T7379	T7367	dobj	domains,reveal
R5148	T7380	T7367	prep	in,reveal
R5149	T7381	T7382	det	the,tube
R5150	T7382	T7380	pobj	tube,in
R5151	T7383	T7382	amod	neural,tube
R5152	T7384	T7382	punct	", ",tube
R5153	T7385	T7386	npadvmod	somite,derived
R5154	T7386	T7388	amod	derived,mesenchyme
R5155	T7387	T7386	punct	-,derived
R5156	T7388	T7382	conj	mesenchyme,tube
R5157	T7389	T7388	punct	", ",mesenchyme
R5158	T7390	T7388	cc	and,mesenchyme
R5159	T7391	T7392	det	the,wall
R5160	T7392	T7388	conj	wall,mesenchyme
R5161	T7393	T7392	amod	ventral,wall
R5162	T7394	T7392	compound	body,wall
R5163	T7395	T7396	punct	(,Figure
R5164	T7396	T7367	parataxis	Figure,reveal
R5165	T7397	T7396	nummod	8C,Figure
R5166	T7398	T7396	punct	),Figure
R5167	T7399	T7367	punct	.,reveal
R5168	T7401	T7402	det	An,section
R5169	T7402	T7404	nsubj	section,reveals
R5170	T7403	T7402	amod	adjacent,section
R5171	T7405	T7402	acl	hybridized,section
R5172	T7406	T7405	prep	with,hybridized
R5173	T7407	T7406	pobj	Tbx15,with
R5174	T7408	T7409	det	a,pattern
R5175	T7409	T7404	dobj	pattern,reveals
R5176	T7410	T7409	amod	complementary,pattern
R5177	T7411	T7409	prep	in,pattern
R5178	T7412	T7413	det	the,flank
R5179	T7413	T7411	pobj	flank,in
R5180	T7414	T7409	punct	", ",pattern
R5181	T7415	T7416	dep	which,provides
R5182	T7416	T7409	relcl	provides,pattern
R5183	T7417	T7418	amod	additional,evidence
R5184	T7418	T7416	dobj	evidence,provides
R5185	T7419	T7418	prep	for,evidence
R5186	T7420	T7421	amod	developmental,mechanisms
R5187	T7421	T7419	pobj	mechanisms,for
R5188	T7422	T7423	dep	that,establish
R5189	T7423	T7421	relcl	establish,mechanisms
R5190	T7424	T7425	det	a,boundary
R5191	T7425	T7423	dobj	boundary,establish
R5192	T7426	T7425	compound	pigmentation,boundary
R5193	T7427	T7428	advmod	entirely,within
R5194	T7428	T7425	prep	within,boundary
R5195	T7429	T7430	amod	lateral,plate
R5196	T7430	T7431	compound	plate,mesoderm
R5197	T7431	T7428	pobj	mesoderm,within
R5198	T7432	T7428	cc	and,within
R5199	T7433	T7428	conj	independent,within
R5200	T7434	T7433	prep	of,independent
R5201	T7435	T7436	compound	lineage,restrictions
R5202	T7436	T7434	pobj	restrictions,of
R5203	T7437	T7436	acl	imposed,restrictions
R5204	T7438	T7437	agent	by,imposed
R5205	T7439	T7440	det	the,frontier
R5206	T7440	T7438	pobj	frontier,by
R5207	T7441	T7440	amod	lateral,frontier
R5208	T7442	T7440	amod	somitic,frontier
R5209	T7443	T7404	punct	.,reveals
R1609	T2605	T2606	amod	differentiated,state
R1610	T2606	T2601	conj	state,number
R1611	T2607	T2601	prep	of,number
R1612	T2608	T2609	compound	pigment,cells
R1613	T2609	T2607	pobj	cells,of
R1614	T2610	T2601	punct	", ",number
R1615	T2611	T2612	advmod	as,as
R1618	T2614	T2615	det	the,type
R1619	T2615	T2601	conj	type,number
R1620	T2616	T2615	prep	of,type
R1621	T2617	T2616	pobj	pigment,of
R1622	T2618	T2615	acl	synthesized,type
R1623	T2619	T2618	prep	in,synthesized
R1624	T2620	T2619	pobj	response,in
R1625	T2621	T2620	prep	to,response
R1626	T2622	T2621	pobj	expression,to
R1627	T2623	T2622	prep	of,expression
R1628	T2624	T2623	pobj	Agouti,of
R1629	T2625	T2591	punct	.,represent
R1630	T2627	T2628	prep	In,vary
R1631	T2629	T2627	amod	particular,In
R1632	T2630	T2628	punct	", ",vary
R1633	T2631	T2632	amod	ventral,hair
R1634	T2632	T2628	nsubj	hair,vary
R1635	T2633	T2632	prep	of,hair
R1636	T2634	T2635	compound	at,at
R1639	T2637	T2633	pobj	animals,of
R1640	T2638	T2628	aux	can,vary
R1641	T2639	T2628	prep	from,vary
R1642	T2640	T2641	npadvmod	cream,colored
R1645	T2643	T2639	prep	to,from
R1646	T2644	T2645	amod	reddish,yellow
R1649	T2647	T2628	prep	depending,vary
R1650	T2648	T2647	prep	on,depending
R1651	T2649	T2648	pobj	age,on
R1652	T2650	T2649	punct	", ",age
R1653	T2651	T2652	compound	strain,background
R1654	T2652	T2649	conj	background,age
R1655	T2653	T2652	punct	", ",background
R1656	T2654	T2652	cc	and,background
R1657	T2655	T2652	conj	position,background
R1658	T2656	T2655	prep	along,position
R1659	T2657	T2658	det	the,axis
R1662	T2660	T2628	punct	.,vary
R1663	T2662	T2663	aux	To,evaluate
R1664	T2663	T2664	advcl	evaluate,compared
R1665	T2665	T2666	det	the,relationship
R1666	T2666	T2663	dobj	relationship,evaluate
R1667	T2667	T2666	prep	among,relationship
R1668	T2668	T2669	det	these,components
R1669	T2669	T2667	pobj	components,among
R1670	T2670	T2664	punct	", ",compared
R1671	T2671	T2664	nsubj	we,compared
R1672	T2672	T2673	poss	their,features
R1673	T2673	T2664	dobj	features,compared
R1674	T2674	T2664	prep	among,compared
R1675	T2675	T2674	pobj	mice,among
R1676	T2676	T2675	prep	of,mice
R1677	T2677	T2678	amod	different,genotypes
R1680	T2680	T2664	punct	.,compared
R1681	T2682	T2683	amod	Semiquantitative,measurements
R1682	T2683	T2684	nsubj	measurements,reveal
R1683	T2685	T2683	prep	of,measurements
R1684	T2686	T2687	compound	hair,length
R1685	T2687	T2685	pobj	length,of
R1686	T2688	T2683	acl	plotted,measurements
R1687	T2689	T2688	prep	as,plotted
R1688	T2690	T2691	det	a,function
R1689	T2691	T2689	pobj	function,as
R1690	T2692	T2691	prep	of,function
R1691	T2693	T2694	amod	dorsoventral,position
R1692	T2694	T2692	pobj	position,of
R1693	T2695	T2696	mark	that,coincides
R1707	T2709	T2711	compound	at,mice
R1710	T2712	T2696	prep	with,coincides
R1711	T2713	T2714	det	a,change
R1715	T2717	T2714	prep	in,change
R1716	T2718	T2719	preconj	both,color
R1719	T2721	T2719	cc	and,color
R1720	T2722	T2723	compound	hair,length
R1721	T2723	T2719	conj	length,color
R1722	T2724	T2725	punct	(,1A
R1725	T2727	T2728	punct	–,1D
R1726	T2728	T2725	prep	1D,1A
R1727	T2729	T2725	punct	),1A
R1728	T2730	T2684	punct	.,reveal
R1729	T2732	T2733	prep	Within,become
R1730	T2734	T2735	det	the,region
R1731	T2735	T2732	pobj	region,Within
R1732	T2736	T2735	prep	of,region
R1733	T2737	T2736	pobj	transition,of
R1734	T2738	T2737	prep	from,transition
R1735	T2739	T2738	pobj	dorsum,from
R1736	T2740	T2737	prep	to,transition
R1737	T2741	T2740	pobj	ventrum,to
R1738	T2742	T2743	punct	(,Figure
R1832	T2842	T2843	amod	different,age
R1833	T2843	T2841	pobj	age,of
R1834	T2844	T2843	punct	", ",age
R1835	T2845	T2843	conj	size,age
R1836	T2846	T2845	punct	", ",size
R1837	T2847	T2845	cc	and,size
R1838	T2848	T2849	compound	Agouti,genotype
R1839	T2849	T2845	conj	genotype,size
R1840	T2850	T2832	advmod	also,are
R1841	T2851	T2852	advmod	very,similar
R1842	T2852	T2832	acomp	similar,are
R1843	T2853	T2854	advmod	when,normalized
R1844	T2854	T2832	advcl	normalized,are
R1845	T2855	T2854	prep	to,normalized
R1846	T2856	T2857	compound	body,circumference
R1847	T2857	T2855	pobj	circumference,to
R1848	T2858	T2859	punct	(,Figure
R1960	T2978	T2976	nmod	al.,Forsthoefel
R1961	T2979	T2976	nummod	1966,Forsthoefel
R1962	T2980	T2976	punct	),Forsthoefel
R1963	T2981	T2962	punct	", ",disappear
R1964	T2982	T2962	cc	and,disappear
R1965	T2983	T2962	punct	", ",disappear
R1966	T2984	T2985	advmod	overall,is
R1973	T2991	T2989	pobj	types,of
R1975	T2993	T2994	advmod	also,similar
R1976	T2994	T2985	acomp	similar,is
R1977	T2995	T2985	prep	in,is
R1978	T2996	T2995	pobj	dorsa,in
R1979	T2997	T2996	cc	and,dorsa
R1980	T2998	T2996	conj	ventra,dorsa
R1981	T2999	T2996	prep	of,dorsa
R1982	T3000	T3001	amod	adult,mice
R1983	T3001	T2999	pobj	mice,of
R1984	T3002	T2985	punct	.,is
R1985	T3004	T3005	prep	In,observed
R1986	T3006	T3007	npadvmod	age,matched
R1991	T3011	T3005	punct	", ",observed
R1992	T3012	T3005	nsubj	we,observed
R1993	T3013	T3014	det	a,decrease
R1996	T3016	T3014	prep	in,decrease
R1997	T3017	T3018	det	the,ratio
R1998	T3018	T3016	pobj	ratio,in
R1999	T3019	T3018	prep	of,ratio
R2000	T3020	T3021	compound	undercoat,hairs
R2001	T3021	T3019	pobj	hairs,of
R2002	T3022	T3023	punct	(,zigzags
R2119	T3143	T3144	det	an,indicator
R2120	T3144	T3142	pobj	indicator,as
R2121	T3145	T3144	prep	of,indicator
R2122	T3146	T3147	compound	tyrosinase,activity
R2123	T3147	T3145	pobj	activity,of
R2124	T3148	T3139	punct	", ",observed
R2125	T3149	T3139	nsubj	we,observed
R2126	T3150	T3151	det	a,transition
R2130	T3154	T3139	prep	in,observed
R2131	T3155	T3156	amod	isolated,preparations
R2134	T3158	T3156	prep	from,preparations
R2135	T3159	T3160	compound	P4.5,mice
R2138	T3162	T3160	compound	ae,mice
R2140	T3164	T3165	punct	(,Figure
R2247	T3279	T3273	dative	dorsal,distinguish
R2248	T3280	T3273	prep	from,distinguish
R2249	T3281	T3280	pobj	ventral,from
R2250	T3282	T3273	dobj	skin,distinguish
R2251	T3283	T3273	punct	: ,distinguish
R2252	T3284	T3273	dobj	differences,distinguish
R2253	T3285	T3284	prep	in,differences
R2254	T3286	T3287	compound	pigment,type
R2257	T3289	T3285	pobj	synthesis,in
R2258	T3290	T3284	punct	(,differences
R2259	T3291	T3284	prep	depending,differences
R2260	T3292	T3291	prep	on,depending
R2261	T3293	T3294	compound	Agouti,genotype
R2262	T3294	T3292	pobj	genotype,on
R2263	T3295	T3284	punct	),differences
R2264	T3296	T3284	punct	", ",differences
R2265	T3297	T3284	conj	differences,differences
R2266	T3298	T3297	prep	in,differences
R2267	T3299	T3300	compound	hair,length
R2268	T3300	T3298	pobj	length,in
R2269	T3301	T3297	punct	", ",differences
R2270	T3302	T3297	cc	and,differences
R2271	T3303	T3297	conj	differences,differences
R2272	T3304	T3303	prep	in,differences
R2273	T3305	T3306	compound	melanin,content
R2274	T3306	T3304	pobj	content,in
R2275	T3307	T3273	punct	.,distinguish
R2283	T3541	T3539	pobj	Mutation,by
R2352	T3614	T3612	attr	characteristic,are
R2371	T3633	T3629	conj	area,fissures
R2587	T3857	T3855	pobj	stripe,as
R2622	T3892	T3883	conj	region,boundary
R2627	T3897	T3892	relcl	reduced,region
R2756	T4032	T4029	dobj	characteristics,affects
R2781	T4058	T4061	ccomp	causes,is
R4287	T6292	T6280	ccomp	gives,showed
R4112	T5938	T5935	advcl	explained,are
R3254	T4788	T4778	conj	sequence,information
R3488	T5035	T5040	advcl	was,generated
R1556	T2547	T2548	amod	Morphological,Components
R1557	T2549	T2548	prep	of,Components
R1558	T2550	T2551	amod	Dorsoventral,Differences
R1561	T2554	T2555	prep	Besides,suggests
R1562	T2556	T2557	det	the,change
R1565	T2559	T2557	prep	in,change
R1566	T2560	T2561	compound	hair,color
R1567	T2561	T2559	pobj	color,in
R1568	T2562	T2563	dep	that,distinguishes
R1571	T2565	T2563	dative	dorsal,distinguishes
R1572	T2566	T2563	prep	from,distinguishes
R1573	T2567	T2566	pobj	ventral,from
R1574	T2568	T2563	dobj	skin,distinguishes
R1575	T2569	T2555	punct	", ",suggests
R1576	T2570	T2571	amod	casual,observation
R1577	T2571	T2555	nsubj	observation,suggests
R1578	T2572	T2573	expl	there,are
R1579	T2573	T2555	advcl	are,suggests
R1580	T2574	T2575	amod	additional,differences
R1581	T2575	T2573	attr	differences,are
R1582	T2576	T2575	prep	in,differences
R1583	T2577	T2578	compound	hair,length
R1584	T2578	T2576	pobj	length,in
R1585	T2579	T2578	punct	", ",length
R1586	T2580	T2578	conj	distribution,length
R1587	T2581	T2580	prep	of,distribution
R1588	T2582	T2583	compound	hair,type
R1589	T2583	T2581	pobj	type,of
R1590	T2584	T2580	punct	", ",distribution
R1591	T2585	T2580	cc	and,distribution
R1592	T2586	T2587	compound	skin,thickness
R1593	T2587	T2580	conj	thickness,distribution
R1594	T2588	T2555	punct	.,suggests
R1595	T2590	T2591	advmod	Furthermore,represent
R1596	T2592	T2591	punct	", ",represent
R1597	T2593	T2594	amod	dorsoventral,differences
R1598	T2594	T2591	nsubj	differences,represent
R1599	T2595	T2594	prep	in,differences
R1600	T2596	T2595	pobj	pigmentation,in
R1601	T2597	T2591	aux	can,represent
R1602	T2598	T2591	dobj	differences,represent
R1603	T2599	T2598	prep	in,differences
R1604	T2600	T2601	det	the,number
R1605	T2601	T2599	pobj	number,in
R1606	T2602	T2601	cc	and,number
R1607	T2603	T2602	punct	/,and
R1608	T2604	T2602	cc	or,and
R1739	T2743	T2735	parataxis	Figure,region
R1740	T2744	T2743	nummod	1B,Figure
R1741	T2745	T2743	punct	),Figure
R1742	T2746	T2733	punct	", ",become
R1743	T2747	T2748	compound	flank,hairs
R1744	T2748	T2733	nsubj	hairs,become
R1745	T2749	T2748	prep	from,hairs
R1746	T2750	T2751	compound	at,at
R1749	T2753	T2749	pobj	mice,from
R1750	T2754	T2755	advmod	progressively,shorter
R1751	T2755	T2733	acomp	shorter,become
R1752	T2756	T2733	cc	and,become
R1753	T2757	T2733	conj	exhibit,become
R1754	T2758	T2759	amod	increasing,amounts
R1755	T2759	T2757	dobj	amounts,exhibit
R1756	T2760	T2759	prep	of,amounts
R1757	T2761	T2762	compound	pheomelanin,deposition
R1758	T2762	T2760	pobj	deposition,of
R1759	T2763	T2762	amod	progressing,deposition
R1760	T2764	T2757	prep	from,exhibit
R1761	T2765	T2766	det	the,tip
R1762	T2766	T2764	pobj	tip,from
R1763	T2767	T2764	prep	to,from
R1764	T2768	T2769	det	the,base
R1765	T2769	T2767	pobj	base,to
R1766	T2770	T2764	prep	of,from
R1767	T2771	T2772	det	the,hair
R1768	T2772	T2770	pobj	hair,of
R1769	T2773	T2733	punct	.,become
R1770	T2775	T2776	advmod	However,is
R1771	T2777	T2776	punct	", ",is
R1772	T2778	T2779	det	the,region
R1773	T2779	T2776	nsubj	region,is
R1774	T2780	T2779	prep	of,region
R1775	T2781	T2780	pobj	transition,of
R1776	T2782	T2776	prep	for,is
R1777	T2783	T2784	compound	hair,length
R1778	T2784	T2782	pobj	length,for
R1779	T2785	T2786	advmod	considerably,broader
R1780	T2786	T2776	acomp	broader,is
R1781	T2787	T2786	prep	than,broader
R1782	T2788	T2787	pobj	that,than
R1783	T2789	T2788	prep	for,that
R1784	T2790	T2789	pobj	pigmentation,for
R1785	T2791	T2786	cc	and,broader
R1786	T2792	T2786	conj	independent,broader
R1787	T2793	T2792	prep	of,independent
R1788	T2794	T2795	compound	Agouti,genotype
R1789	T2795	T2793	pobj	genotype,of
R1790	T2796	T2776	punct	.,is
R1791	T2798	T2799	mark	Although,varies
R1794	T2801	T2803	compound	cycle,timing
R1797	T2805	T2799	prep	along,varies
R1798	T2806	T2807	det	the,axis
R1801	T2809	T2804	punct	", ",are
R1802	T2810	T2804	nsubj	measurements,are
R1803	T2811	T2810	prep	of,measurements
R1804	T2812	T2813	amod	absolute,length
R1807	T2815	T2810	prep	for,measurements
R1808	T2816	T2815	pobj	mice,for
R1809	T2817	T2816	acl	matched,mice
R1810	T2818	T2817	prep	for,matched
R1811	T2819	T2818	pobj	age,for
R1812	T2820	T2819	cc	and,age
R1813	T2821	T2822	amod	rostrocaudal,level
R1814	T2822	T2819	conj	level,age
R1815	T2823	T2824	advmod	remarkably,similar
R1816	T2824	T2804	acomp	similar,are
R1817	T2825	T2826	punct	(,Figure
R1818	T2826	T2804	parataxis	Figure,are
R1819	T2827	T2826	nummod	1D,Figure
R1820	T2828	T2826	punct	),Figure
R1821	T2829	T2804	punct	.,are
R1822	T2831	T2832	advmod	Furthermore,are
R1823	T2833	T2832	punct	", ",are
R1824	T2834	T2832	nsubj	measurements,are
R1825	T2835	T2834	prep	of,measurements
R1826	T2836	T2837	amod	relative,length
R1829	T2839	T2832	prep	for,are
R1830	T2840	T2839	pobj	animals,for
R1831	T2841	T2840	prep	of,animals
R1849	T2859	T2832	parataxis	Figure,are
R1850	T2860	T2859	nummod	1C,Figure
R1851	T2861	T2859	punct	),Figure
R1852	T2862	T2832	punct	.,are
R1853	T2864	T2865	advcl	Taken,indicate
R1854	T2866	T2864	advmod	together,Taken
R1855	T2867	T2865	punct	", ",indicate
R1856	T2868	T2869	det	these,observations
R1857	T2869	T2865	nsubj	observations,indicate
R1858	T2870	T2871	mark	that,stereotyped
R1866	T2878	T2876	pobj	axis,along
R1869	T2881	T2871	cc	and,stereotyped
R1870	T2882	T2871	conj	maintained,stereotyped
R1871	T2883	T2871	prep	through,stereotyped
R1872	T2884	T2885	amod	multiple,cycles
R1875	T2887	T2871	punct	", ",stereotyped
R1876	T2888	T2871	prep	with,stereotyped
R1877	T2889	T2890	det	a,transition
R1878	T2890	T2888	pobj	transition,with
R1879	T2891	T2890	prep	in,transition
R1880	T2892	T2893	compound	hair,length
R1881	T2893	T2891	pobj	length,in
R1882	T2894	T2895	dep	that,is
R1883	T2895	T2890	relcl	is,transition
R1884	T2896	T2895	acomp	gradual,is
R1885	T2897	T2895	cc	and,is
R1886	T2898	T2895	conj	encompasses,is
R1887	T2899	T2900	det	the,transition
R1890	T2902	T2900	compound	type,transition
R1892	T2904	T2895	prep	in,is
R1893	T2905	T2906	compound	at,at
R1896	T2908	T2904	pobj	mice,in
R1897	T2909	T2865	punct	.,indicate
R1898	T2911	T2912	amod	Dorsal,skin
R1902	T2916	T2915	prep	at,develop
R1903	T2917	T2918	amod	different,rates
R1904	T2918	T2916	pobj	rates,at
R1905	T2919	T2915	punct	.,develop
R1906	T2921	T2922	amod	Transverse,sections
R1907	T2922	T2923	nsubj	sections,exhibit
R1908	T2924	T2922	prep	of,sections
R1909	T2925	T2924	pobj	skin,of
R1910	T2926	T2922	prep	at,sections
R1911	T2927	T2928	amod	postnatal,day
R1912	T2928	T2926	pobj	day,at
R1913	T2929	T2928	nummod	4.5,day
R1914	T2930	T2928	punct	(,day
R1915	T2931	T2928	appos	P4.5,day
R1916	T2932	T2928	punct	),day
R1917	T2933	T2934	amod	dorsal,follicles
R1920	T2936	T2937	dep	that,are
R1921	T2937	T2934	relcl	are,follicles
R1922	T2938	T2939	advmod	noticeably,developed
R1925	T2941	T2939	prep	than,developed
R1926	T2942	T2943	amod	ventral,follicles
R1929	T2945	T2934	punct	", ",follicles
R1930	T2946	T2934	prep	along,follicles
R1931	T2947	T2946	prep	with,along
R1932	T2948	T2949	det	a,decrease
R1936	T2952	T2949	prep	in,decrease
R1937	T2953	T2954	amod	dermal,thickness
R1938	T2954	T2952	pobj	thickness,in
R1939	T2955	T2956	punct	(,Figure
R1940	T2956	T2923	parataxis	Figure,exhibit
R1941	T2957	T2956	nummod	1F,Figure
R1942	T2958	T2956	punct	),Figure
R1943	T2959	T2923	punct	.,exhibit
R1944	T2961	T2962	advmod	However,disappear
R1945	T2963	T2962	punct	", ",disappear
R1946	T2964	T2962	nsubj	differences,disappear
R1947	T2965	T2964	prep	in,differences
R1948	T2966	T2967	compound	skin,thickness
R1949	T2967	T2965	pobj	thickness,in
R1950	T2968	T2962	prep	by,disappear
R1951	T2969	T2970	quantmod	3,4
R1954	T2972	T2968	pobj	wk,by
R1955	T2973	T2972	prep	of,wk
R1956	T2974	T2973	pobj	age,of
R1957	T2975	T2976	punct	(,Forsthoefel
R1958	T2976	T2962	meta	Forsthoefel,disappear
R1959	T2977	T2976	nmod	et,Forsthoefel
R2003	T3023	T3021	parataxis	zigzags,hairs
R2004	T3024	T3023	punct	),zigzags
R2005	T3025	T3018	prep	to,ratio
R2006	T3026	T3027	compound	overcoat,hairs
R2007	T3027	T3025	pobj	hairs,to
R2008	T3028	T3027	punct	(,hairs
R2009	T3029	T3027	appos	auchenes,hairs
R2010	T3030	T3029	punct	", ",auchenes
R2011	T3031	T3029	conj	awls,auchenes
R2012	T3032	T3031	punct	", ",awls
R2013	T3033	T3031	cc	and,awls
R2014	T3034	T3035	compound	guard,hairs
R2015	T3035	T3031	conj	hairs,awls
R2016	T3036	T3005	punct	),observed
R2017	T3037	T3005	prep	in,observed
R2018	T3038	T3037	pobj	dorsum,in
R2019	T3039	T3005	prep	compared,observed
R2020	T3040	T3039	prep	to,compared
R2021	T3041	T3040	pobj	ventrum,to
R2022	T3042	T3043	punct	(,Figure
R2023	T3043	T3005	parataxis	Figure,observed
R2024	T3044	T3043	nummod	1E,Figure
R2025	T3045	T3043	punct	),Figure
R2026	T3046	T3005	punct	", ",observed
R2027	T3047	T3005	cc	but,observed
R2028	T3048	T3049	expl	there,was
R2029	T3049	T3005	conj	was,observed
R2030	T3050	T3051	det	no,difference
R2033	T3053	T3051	prep	in,difference
R2034	T3054	T3055	compound	hair,type
R2037	T3057	T3053	pobj	distribution,in
R2038	T3058	T3057	prep	for,distribution
R2039	T3059	T3060	amod	outbred,mice
R2040	T3060	T3058	pobj	mice,for
R2041	T3061	T3062	punct	(,shown
R2045	T3065	T3062	punct	),shown
R2046	T3066	T3049	punct	.,was
R2047	T3068	T3069	nsubjpass	Differences,attributed
R2048	T3070	T3068	prep	between,Differences
R2049	T3071	T3072	amod	dorsal,pigmentation
R2053	T3075	T3072	prep	of,pigmentation
R2054	T3076	T3077	compound	at,at
R2057	T3079	T3075	pobj	mice,of
R2058	T3080	T3069	auxpass	are,attributed
R2059	T3081	T3069	advmod	usually,attributed
R2060	T3082	T3069	prep	to,attributed
R2061	T3083	T3084	compound	pigment,type
R2064	T3086	T3082	pobj	differences,to
R2065	T3087	T3086	acl	caused,differences
R2066	T3088	T3087	agent	by,caused
R2067	T3089	T3090	amod	ventral,specific
R2070	T3092	T3088	pobj	expression,by
R2071	T3093	T3092	prep	of,expression
R2072	T3094	T3093	pobj	Agouti,of
R2073	T3095	T3069	punct	", ",attributed
R2074	T3096	T3069	cc	but,attributed
R2075	T3097	T3098	nsubj	animals,have
R2080	T3102	T3100	pobj	allele,for
R2091	T3113	T3114	amod	ventral,hairs
R2092	T3114	T3098	dobj	hairs,have
R2093	T3115	T3116	dep	that,contain
R2094	T3116	T3114	relcl	contain,hairs
R2095	T3117	T3118	amod	less,melanin
R2096	T3118	T3116	dobj	melanin,contain
R2097	T3119	T3118	prep	than,melanin
R2098	T3120	T3121	amod	dorsal,hairs
R2099	T3121	T3119	pobj	hairs,than
R2100	T3122	T3116	punct	", ",contain
R2101	T3123	T3116	advcl	giving,contain
R2102	T3124	T3125	det	a,appearance
R2106	T3128	T3123	dative	to,giving
R2107	T3129	T3130	det	the,coat
R2110	T3132	T3133	punct	(,Figure
R2111	T3133	T3098	parataxis	Figure,have
R2112	T3134	T3133	nummod	1G,Figure
R2113	T3135	T3133	punct	),Figure
R2114	T3136	T3098	punct	.,have
R2115	T3138	T3139	advcl	Using,observed
R2116	T3140	T3141	compound	DOPA,staining
R2117	T3141	T3138	dobj	staining,Using
R2118	T3142	T3138	prep	as,Using
R2141	T3165	T3139	parataxis	Figure,observed
R2142	T3166	T3165	nummod	1G,Figure
R2143	T3167	T3165	punct	),Figure
R2144	T3168	T3139	punct	.,observed
R2145	T3170	T3171	prep	By,reveal
R2146	T3172	T3170	pobj	contrast,By
R2147	T3173	T3171	punct	", ",reveal
R2148	T3174	T3171	nsubj	skin,reveal
R2149	T3175	T3174	prep	from,skin
R2150	T3176	T3177	compound	at,at
R2153	T3179	T3175	pobj	mice,from
R2154	T3180	T3181	det	an,transition
R2158	T3184	T3181	prep	of,transition
R2159	T3185	T3186	compound	DOPA,staining
R2160	T3186	T3184	pobj	staining,of
R2161	T3187	T3181	punct	", ",transition
R2162	T3188	T3189	dep	which,reflects
R2165	T3191	T3192	det	the,effects
R2168	T3194	T3192	prep	of,effects
R2169	T3195	T3196	amod	reduced,content
R2172	T3198	T3196	punct	(,content
R2173	T3199	T3196	prep	as,content
R2174	T3200	T3199	prep	in,as
R2175	T3201	T3202	compound	ae,ae
R2178	T3204	T3200	pobj	mice,in
R2179	T3205	T3192	punct	),effects
R2180	T3206	T3192	cc	and,effects
R2181	T3207	T3192	conj	downregulation,effects
R2182	T3208	T3207	prep	of,downregulation
R2183	T3209	T3210	compound	tyrosinase,activity
R2184	T3210	T3208	pobj	activity,of
R2185	T3211	T3210	acl	induced,activity
R2186	T3212	T3211	agent	by,induced
R2187	T3213	T3212	pobj	Agouti,by
R2188	T3214	T3171	punct	.,reveal
R2189	T3216	T3217	compound	Melanin,content
R2190	T3217	T3218	nsubj	content,is
R2191	T3219	T3217	prep	of,content
R2192	T3220	T3221	amod	individual,hairs
R2193	T3221	T3219	pobj	hairs,of
R2194	T3222	T3218	acomp	likely,is
R2195	T3223	T3224	aux	to,influenced
R2198	T3226	T3227	preconj	both,by
R2199	T3227	T3224	agent	by,influenced
R2200	T3228	T3229	det	the,number
R2201	T3229	T3227	pobj	number,by
R2202	T3230	T3229	prep	of,number
R2203	T3231	T3232	compound	pigment,cells
R2204	T3232	T3230	pobj	cells,of
R2205	T3233	T3229	cc	and,number
R2206	T3234	T3235	poss	their,environment
R2209	T3237	T3218	punct	.,is
R2210	T3239	T3240	advmod	Regardless,persist
R2211	T3241	T3240	punct	", ",persist
R2212	T3242	T3243	amod	dorsoventral,differences
R2213	T3243	T3240	nsubj	differences,persist
R2214	T3244	T3243	prep	in,differences
R2215	T3245	T3246	compound	hair,content
R2218	T3248	T3246	prep	of,content
R2219	T3249	T3250	compound	ae,ae
R2222	T3252	T3248	pobj	mice,of
R2223	T3253	T3240	prep	throughout,persist
R2224	T3254	T3255	amod	multiple,cycles
R2227	T3257	T3240	prep	into,persist
R2228	T3258	T3257	pobj	adulthood,into
R2229	T3259	T3240	punct	", ",persist
R2230	T3260	T3240	advcl	similar,persist
R2231	T3261	T3260	prep	to,similar
R2232	T3262	T3263	compound	hair,length
R2233	T3263	T3261	pobj	length,to
R2234	T3264	T3260	punct	(,similar
R2235	T3265	T3260	cc	but,similar
R2236	T3266	T3260	conj	unlike,similar
R2237	T3267	T3268	compound	skin,thickness
R2238	T3268	T3266	pobj	thickness,unlike
R2239	T3269	T3240	punct	),persist
R2240	T3270	T3240	punct	.,persist
R2241	T3272	T3273	advmod	Thus,distinguish
R2242	T3274	T3273	punct	", ",distinguish
R2243	T3275	T3276	advmod	at,three
R2246	T3278	T3273	nsubj	characteristics,distinguish
R2848	T4128	T4121	parataxis	shown,display
R2871	T4153	T4151	pobj	days,in
R3021	T4311	T4309	pobj	skin,between

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T2336	97-101	UBERON:0001037	denotes	hair
T2337	228-232	UBERON:0001037	denotes	hair
T2338	257-261	UBERON:0001037	denotes	hair
T2339	413-420	CHEBI:26130	denotes	pigment
T2340	413-426	CL:0000147	denotes	pigment cells
T2341	451-458	CHEBI:26130	denotes	pigment
T2342	486-496	GO:0010467	denotes	expression
T2343	500-506	PR:000004372	denotes	Agouti
T2344	531-535	UBERON:0001037	denotes	hair
T2345	545-552	NCBITaxon:33208	denotes	animals
T2346	764-768	NCBITaxon:10088	denotes	mice
T2347	782-788	PR:000004372	denotes	Agouti
T2348	833-837	UBERON:0001037	denotes	hair
T2349	959-966	CHEBI:26130	denotes	pigment
T2350	989-993	NCBITaxon:10088	denotes	mice
T2351	1039-1043	UBERON:0001037	denotes	hair
T2352	1054-1058	UBERON:0001037	denotes	hair
T2353	1119-1125	UBERON:0001137	denotes	dorsum
T2354	1129-1136	UBERON:0013235	denotes	ventrum
T2355	1150-1155	UBERON:0000180	denotes	flank
T2356	1156-1161	UBERON:0001037	denotes	hairs
T2357	1173-1177	NCBITaxon:10088	denotes	mice
T2358	1241-1252	CHEBI:81393	denotes	pheomelanin
T2359	1308-1312	UBERON:0001037	denotes	hair
T2360	1352-1356	UBERON:0001037	denotes	hair
T2361	1434-1440	PR:000004372	denotes	Agouti
T2362	1460-1464	UBERON:0001037	denotes	hair
T2363	1460-1470	GO:0042633	denotes	hair-cycle
T2364	1539-1543	UBERON:0001037	denotes	hair
T2365	1555-1559	NCBITaxon:10088	denotes	mice
T2366	1673-1677	UBERON:0001037	denotes	hair
T2367	1689-1696	NCBITaxon:33208	denotes	animals
T2368	1725-1731	PR:000004372	denotes	Agouti
T2369	1876-1880	UBERON:0001037	denotes	hair
T2370	1963-1967	UBERON:0001037	denotes	hair
T2371	1963-1974	GO:0042633	denotes	hair cycles
T2372	1997-2001	UBERON:0001037	denotes	hair
T2373	2045-2052	CHEBI:26130	denotes	pigment
T2374	2078-2082	NCBITaxon:10088	denotes	mice
T2375	3317-3322	GO:0007567	denotes	natal
T2376	3353-3367	UBERON:0002073	denotes	hair follicles
T2377	3416-3430	UBERON:0002073	denotes	hair follicles
T2378	3643-3647	UBERON:0001037	denotes	hair
T2379	3673-3678	UBERON:0001137	denotes	dorsa
T2380	3683-3689	UBERON:0013235	denotes	ventra
T2381	3693-3698	UBERON:0007023	denotes	adult
T2382	3699-3703	NCBITaxon:10088	denotes	mice
T2383	3727-3731	NCBITaxon:10088	denotes	mice
T2384	3788-3793	UBERON:0001037	denotes	hairs
T2385	3795-3802	UBERON:0010513	denotes	zigzags
T2386	3816-3821	UBERON:0001037	denotes	hairs
T2387	3823-3831	UBERON:0010510	denotes	auchenes
T2388	3833-3837	UBERON:0010511	denotes	awls
T2389	3843-3854	UBERON:0010512	denotes	guard hairs
T2390	3859-3865	UBERON:0001137	denotes	dorsum
T2391	3878-3885	UBERON:0013235	denotes	ventrum
T2392	3941-3945	UBERON:0001037	denotes	hair
T2393	3976-3980	NCBITaxon:10088	denotes	mice
T2394	4060-4064	NCBITaxon:10088	denotes	mice
T2395	4091-4098	CHEBI:26130	denotes	pigment
T2396	4143-4153	GO:0010467	denotes	expression
T2397	4157-4163	PR:000004372	denotes	Agouti
T2398	4169-4176	NCBITaxon:33208	denotes	animals
T2399	4199-4205	SO:0001023	denotes	allele
T2400	4209-4215	PR:000004372	denotes	Agouti
T2401	4254-4259	UBERON:0001037	denotes	hairs
T2402	4278-4285	CHEBI:25179	denotes	melanin
T2403	4298-4303	UBERON:0001037	denotes	hairs
T2404	4355-4359	UBERON:0010166	denotes	coat
T2405	4379-4383	CHEBI:49168	denotes	DOPA
T2406	4491-4497	UBERON:0002067	denotes	dermis
T2407	4527-4531	NCBITaxon:10088	denotes	mice
T2408	4574-4578	NCBITaxon:10088	denotes	mice
T2409	4623-4627	CHEBI:49168	denotes	DOPA
T2410	4694-4701	CHEBI:25179	denotes	melanin
T2411	4723-4727	NCBITaxon:10088	denotes	mice
T2412	4782-4788	PR:000004372	denotes	Agouti
T2413	4790-4797	CHEBI:25179	denotes	Melanin
T2414	4820-4825	UBERON:0001037	denotes	hairs
T2415	4875-4882	CHEBI:26130	denotes	pigment
T2416	4875-4888	CL:0000147	denotes	pigment cells
T2417	4963-4967	UBERON:0001037	denotes	hair
T2418	4968-4975	CHEBI:26130	denotes	pigment
T2419	4993-4997	NCBITaxon:10088	denotes	mice
T2420	5026-5030	UBERON:0001037	denotes	hair
T2421	5026-5037	GO:0042633	denotes	hair cycles
T2422	5043-5052	UBERON:0000113	denotes	adulthood
T2423	5065-5069	UBERON:0001037	denotes	hair
T2424	5196-5203	CHEBI:26130	denotes	pigment
T2425	5233-5239	PR:000004372	denotes	Agouti
T2426	5266-5270	UBERON:0001037	denotes	hair
T2427	5298-5305	CHEBI:25179	denotes	melanin
T3347	5364-5367	UBERON:0001690	denotes	ear
T3348	5436-5439	UBERON:0001690	denotes	ear
T3349	5467-5472	NCBITaxon:10088	denotes	mouse
T3350	5500-5506	SO:0001023	denotes	allele
T3351	5791-5798	NCBITaxon:33208	denotes	animals
T3352	5824-5828	UBERON:0000970	denotes	eyes
T3353	5836-5854	UBERON:0001819	denotes	palpebral fissures
T3354	5864-5869	UBERON:0000004	denotes	nasal
T3355	5892-5897	UBERON:0003129	denotes	skull
T3356	5999-6003	UBERON:0001690	denotes	ears
T3357	6036-6039	UBERON:0001690	denotes	ear
T3358	6061-6067	SO:0001023	denotes	allele
T3359	6092-6099	CHEBI:26130	denotes	pigment
T3360	6182-6189	SO:0000704	denotes	genetic
T3361	6209-6210	PR:000004372	denotes	A
T3362	6230-6235	UBERON:0000916	denotes	belly
T3363	6236-6240	UBERON:0001037	denotes	hair
T3364	6264-6268	UBERON:0011270	denotes	back
T3365	6269-6273	UBERON:0001037	denotes	hair
T3366	6279-6284	UBERON:0000916	denotes	belly
T3367	6285-6289	UBERON:0001037	denotes	hair
T3368	6339-6343	UBERON:0001456	denotes	face
T3369	6384-6391	CHEBI:26130	denotes	pigment
T3370	6438-6442	NCBITaxon:10088	denotes	mice
T3371	6472-6479	NCBITaxon:33208	denotes	animals
T3372	6608-6613	UBERON:0001037	denotes	hairs
T3373	6687-6691	UBERON:0002101	denotes	limb
T3374	6692-6701	UBERON:0000309	denotes	body wall
T3375	6838-6842	NCBITaxon:10088	denotes	mice
T3376	6879-6884	UBERON:0001037	denotes	hairs
T3377	6930-6934	NCBITaxon:10088	denotes	mice
T3378	6980-6986	UBERON:2001463	denotes	stripe
T3379	6997-7002	UBERON:0000180	denotes	flank
T3380	7026-7030	NCBITaxon:10088	denotes	mice
T3381	7117-7122	UBERON:0000180	denotes	flank
T3382	7137-7146	CHEBI:24009	denotes	eumelanic
T3383	7271-7278	NCBITaxon:33208	denotes	animals
T3384	7362-7369	NCBITaxon:33208	denotes	animals
T3385	7561-7568	NCBITaxon:33208	denotes	animals
T3386	7661-7666	UBERON:0002101	denotes	limbs
T3387	7675-7682	UBERON:1000019	denotes	cranium
T3388	7696-7703	UBERON:0006378	denotes	whisker
T3389	7704-7707	UBERON:2001977	denotes	pad
T3390	9150-9157	CHEBI:26130	denotes	pigment
T3391	9201-9205	UBERON:0001037	denotes	hair
T3392	9310-9314	UBERON:0001037	denotes	hair
T3393	9330-9336	UBERON:0001137	denotes	dorsum
T3394	9341-9348	UBERON:0013235	denotes	ventrum
T3395	9376-9383	NCBITaxon:33208	denotes	animals
T3396	9431-9435	UBERON:0001037	denotes	hair
T3397	9516-9523	NCBITaxon:33208	denotes	animals
T3398	9556-9564	UBERON:0004288	denotes	skeletal
T3399	9595-9599	UBERON:0010166	denotes	coat
T3400	9733-9738	GO:0007567	denotes	birth
T3401	9772-9783	GO:0042438	denotes	melanogenic
T3402	9848-9859	CL:0000541	denotes	melanoblast
T3403	9879-9891	UBERON:0002342	denotes	neural crest
T3404	9952-9962	CL:0000148	denotes	melanocyte
T3405	9983-9990	CHEBI:26130	denotes	pigment
T3406	9983-10000	GO:0046148	denotes	pigment synthesis
T3407	10068-10074	UBERON:0001137	denotes	dorsum
T3408	10112-10119	_FRAGMENT	denotes	area of
T3409	10125-10129	UBERON:0000014	denotes	skin
T3410	10173-10178	UBERON:0002101	denotes	limbs
T3411	10216-10225	CHEBI:24009	denotes	eumelanin
T3412	10244-10249	UBERON:0007023	denotes	adult
T3413	10250-10257	NCBITaxon:33208	denotes	animals
T3414	10331-10371	GO:0009953	denotes	establishment of dorsoventral patterning
T3415	10379-10395	GO:0043588	denotes	skin development
T3416	10565-10575	CL:0000148	denotes	melanocyte
T3417	10606-10617	CHEBI:81393	denotes	pheomelanin
T3418	10673-10677	UBERON:0001037	denotes	hair
T3419	10690-10697	UBERON:0013235	denotes	ventrum
T3420	10701-10707	UBERON:0001137	denotes	dorsum
T3421	10733-10737	SO:0000704	denotes	gene
T3422	10756-10761	PR:000016145	denotes	Tbx15
T3423	10775-10784	GO:0010467	denotes	expressed
T4427	11006-11009	UBERON:0001690	denotes	ear
T4428	11010-11016	SO:0001023	denotes	allele
T4429	11028-11034	SO:0001023	denotes	allele
T4430	11262-11266	NCBITaxon:10088	denotes	mice
T4431	11379-11388	NCBITaxon:2	denotes	bacterial
T4432	11379-11410	SO:0000153	denotes	bacterial artificial chromosome
T4433	11412-11415	SO:0000153	denotes	BAC
T4434	11417-11423	SO:0000149	denotes	contig
T4435	11487-11492	SO:0000704	denotes	genes
T4436	11504-11509	PR:000016145	denotes	Tbx15
T4437	11537-11542	PR:000016145	denotes	Tbx15
T4438	11577-11585	UBERON:0004288	denotes	skeletal
T4439	11676-11685	UBERON:0000922	denotes	embryonic
T4440	11686-11696	GO:0010467	denotes	expression
T4441	11739-11744	UBERON:0002101	denotes	limbs
T4442	12763-12768	NCBITaxon:10088	denotes	mouse
T4443	12769-12775	SO:0001026	denotes	genome
T4444	12800-12811	_FRAGMENT	denotes	portions of
T4445	12826-12831	SO:0000852	denotes	exons
T4446	12820-12825	PR:000016145	denotes	Tbx15
T4447	12868-12875	SO:0001026	denotes	genomic
T4448	12890-12894	SO:0000704	denotes	gene
T4449	12924-12928	PR:000016145	denotes	Tbx8
T4450	12974-12979	PR:000016145	denotes	Tbx14
T4451	13021-13031	NCBITaxon:7742	denotes	vertebrate
T4452	13032-13039	SO:0001026	denotes	genomes
T4453	13043-13048	PR:000016145	denotes	Tbx15
T4454	13173-13180	SO:0001026	denotes	genomic
T4455	13207-13212	NCBITaxon:10088	denotes	mouse
T4456	13213-13219	SO:0001026	denotes	genome
T4457	13280-13285	PR:000016145	denotes	Tbx15
T4458	13286-13292	SO:0000188	denotes	intron
T4459	13323-13338	GO:0043631	denotes	polyadenylation
T4460	13323-13347	SO:0000610	denotes	polyadenylation sequence
T4461	13375-13394	CHEBI:17369	denotes	mannose-6-phosphate
T4462	13404-13414	SO:0000336	denotes	pseudogene
T4463	13421-13423	SO:0000336	denotes	ps
T4464	13516-13526	SO:0000673	denotes	transcript
T4465	13646-13651	PR:000016145	denotes	Tbx15
T4466	13685-13691	SO:0000417	denotes	domain
T4467	13700-13707	NCBITaxon:33208	denotes	animals
T4468	13757-13764	NCBITaxon:33208	denotes	animals
T4469	13813-13819	SO:0001023	denotes	allele
T4470	13850-13852	SO:0000336	denotes	ps
T4471	13863-13868	SO:0000704	denotes	genes
T4472	13872-13883	SO:0000673	denotes	transcripts
T4473	14033-14038	PR:000016145	denotes	Tbx15
T4474	14042-14046	SO:0000704	denotes	gene
T4475	14060-14069	UBERON:0000922	denotes	embryonic
T4476	14060-14080	CL:0002322	denotes	embryonic stem cells
T4477	14095-14101	SO:0001023	denotes	allele
T4478	14103-14108	PR:000016145	denotes	Tbx15
T4479	14108-14112	PR:000033987	denotes	LacZ
T4480	14125-14129	SO:0000243	denotes	IRES
T4481	14130-14134	PR:000033987	denotes	LacZ
T4482	14144-14152	SO:0005853	denotes	cassette
T4483	14171-14189	SO:0000236	denotes	open reading frame
T4484	14193-14198	SO:0000360	denotes	codon
T4485	14222-14228	SO:0000417	denotes	domain
T4486	14242-14249	NCBITaxon:33208	denotes	Animals
T4487	14280-14286	SO:0001023	denotes	allele
T4488	14330-14338	UBERON:0004288	denotes	skeletal
T4489	14355-14359	UBERON:0001037	denotes	hair
T4490	14384-14389	PR:000016145	denotes	Tbx15
T4491	14389-14393	PR:000033987	denotes	LacZ
T4492	14394-14399	PR:000016145	denotes	Tbx15
T4493	14399-14403	PR:000033987	denotes	LacZ
T4494	14542-14547	PR:000016145	denotes	Tbx15
T4495	14547-14551	PR:000033987	denotes	LacZ
T4496	14610-14617	NCBITaxon:33208	denotes	animals
T4497	14709-14714	UBERON:0000180	denotes	flank
T4498	14751-14758	NCBITaxon:33208	denotes	animals
T4499	14815-14825	CHEBI:26130	denotes	pigmentary
T4500	14901-14906	PR:000016145	denotes	Tbx15
T5281	14923-14928	PR:000016145	denotes	Tbx15
T5282	14933-14939	PR:000004372	denotes	Agouti
T5283	15008-15021	GO:0097617	denotes	hybridization
T5284	15032-15042	GO:0010467	denotes	expression
T5285	15046-15051	PR:000016145	denotes	Tbx15
T5286	15087-15096	UBERON:0004347	denotes	limb buds
T5287	15117-15133	UBERON:0002539	denotes	branchial arches
T5288	15135-15141	UBERON:0000180	denotes	flanks
T5289	15230-15240	GO:0097617	denotes	hybridized
T5290	15243-15248	PR:000016145	denotes	Tbx15
T5291	15317-15327	GO:0010467	denotes	expression
T5292	15340-15362	_FRAGMENT	denotes	mesenchymal tissues of
T5293	15367-15371	UBERON:0005253	denotes	head
T5294	15373-15378	UBERON:0005256	denotes	trunk
T5295	15395-15400	UBERON:0009749	denotes	limbs
T5296	15451-15456	UBERON:0003129	denotes	skull
T5297	15458-15476	UBERON:0002413	denotes	cervical vertebrae
T5298	15482-15486	UBERON:0002101	denotes	limb
T5299	15514-15518	NCBITaxon:10088	denotes	mice
T5300	15548-15551	UBERON:0001690	denotes	ear
T5301	15552-15558	SO:0001023	denotes	allele
T5302	16423-16432	UBERON:0000922	denotes	embryonic
T5303	16433-16438	UBERON:0000180	denotes	flank
T5304	16439-16449	GO:0010467	denotes	expression
T5305	16505-16509	NCBITaxon:10088	denotes	mice
T5306	16522-16531	UBERON:0000916	denotes	abdominal
T5307	16611-16621	GO:0010467	denotes	expression
T5308	16641-16651	UBERON:0003104	denotes	mesenchyme
T5309	16768-16774	UBERON:0002067	denotes	dermis
T5310	16805-16821	UBERON:0007529	denotes	loose mesenchyme
T5311	16840-16852	UBERON:0018260	denotes	muscle layer
T5312	16854-16859	PR:000016145	denotes	Tbx15
T5313	16863-16872	GO:0010467	denotes	expressed
T5314	16922-16939	UBERON:0002378	denotes	abdominal muscles
T5315	16955-16960	PR:000016145	denotes	Tbx15
T5316	16964-16973	GO:0010467	denotes	expressed
T5317	17044-17050	UBERON:0002067	denotes	dermis
T5318	17073-17080	UBERON:0005933	denotes	sheaths
T5319	17084-17098	UBERON:0002073	denotes	hair follicles
T5320	17106-17116	GO:0010467	denotes	expression
T5321	17146-17161	UBERON:0000412	denotes	dermal papillae
T5322	17146-17167	CL:0000346	denotes	dermal papillae cells
T5323	17205-17211	PR:000004372	denotes	Agouti
T5324	17215-17222	CHEBI:26130	denotes	pigment
T5325	17255-17260	GO:0007567	denotes	natal
T5326	17261-17265	UBERON:0001037	denotes	hair
T5327	17295-17302	SO:0001060	denotes	isoform
T5328	17306-17312	PR:000004372	denotes	Agouti
T5329	17316-17325	GO:0010467	denotes	expressed
T5330	17395-17405	GO:0097617	denotes	hybridized
T5331	17422-17427	PR:000016145	denotes	Tbx15
T5332	17432-17438	PR:000004372	denotes	Agouti
T5333	17490-17500	GO:0010467	denotes	expression
T5334	17504-17510	PR:000004372	denotes	Agouti
T5335	17531-17541	GO:0010467	denotes	expression
T5336	17545-17550	PR:000016145	denotes	Tbx15
T5337	17607-17617	GO:0010467	denotes	expression
T5338	17655-17660	PR:000016145	denotes	Tbx15
T5339	17661-17671	GO:0010467	denotes	expression
T5340	17720-17726	PR:000004372	denotes	Agouti
T5341	17727-17737	GO:0010467	denotes	expression
T5342	18303-18313	GO:0010467	denotes	expression
T5343	18317-18323	PR:000004372	denotes	Agouti
T5344	18473-18479	PR:000004372	denotes	Agouti
T5345	18480-18490	GO:0010467	denotes	expression
T5346	18535-18542	UBERON:0000922	denotes	embryos
T5347	18570-18580	GO:0010467	denotes	expression
T5348	18584-18590	PR:000004372	denotes	Agouti
T5349	18628-18635	NCBITaxon:33208	denotes	animals
T5350	18697-18703	UBERON:0002067	denotes	dermis
T5351	18708-18723	UBERON:0000412	denotes	dermal papillae
T5352	18708-18729	CL:0000346	denotes	dermal papillae cells
T5353	18793-18797	NCBITaxon:10088	denotes	mice
T5354	18857-18863	PR:000004372	denotes	Agouti
T5355	18864-18874	GO:0010467	denotes	expression
T5356	18881-18886	GO:0007567	denotes	birth
T5357	18898-18908	GO:0010467	denotes	expression
T5358	18912-18917	PR:000016145	denotes	Tbx15
T5359	18922-18928	PR:000004372	denotes	Agouti
T5360	19008-19013	PR:000016145	denotes	Tbx15
T5361	19028-19038	GO:0010467	denotes	expression
T5362	19042-19048	PR:000004372	denotes	Agouti
T6028	19719-19728	UBERON:0000922	denotes	Embryonic
T6029	19729-19734	PR:000016145	denotes	Tbx15
T6030	19735-19745	GO:0010467	denotes	Expression
T6031	19869-19879	GO:0010467	denotes	expression
T6032	19883-19888	PR:000016145	denotes	Tbx15
T6033	19896-19905	UBERON:0000922	denotes	embryonic
T6034	19913-19918	UBERON:0000180	denotes	flank
T6035	19978-19984	UBERON:0002067	denotes	dermis
T6036	20011-20018	CHEBI:26130	denotes	pigment
T6037	20065-20071	PR:000004372	denotes	Agouti
T6038	20072-20079	SO:0001060	denotes	isoform
T6039	20183-20192	UBERON:0000922	denotes	embryonic
T6040	20268-20277	UBERON:0000922	denotes	embryonic
T6041	20339-20343	UBERON:0001037	denotes	hair
T6042	20365-20375	GO:0010467	denotes	expression
T6043	20379-20384	PR:000016145	denotes	Tbx15
T6044	20389-20395	PR:000004372	denotes	Agouti
T6045	20521-20528	UBERON:0000922	denotes	embryos
T6046	20560-20564	UBERON:0001037	denotes	hair
T6047	20603-20609	UBERON:0000473	denotes	testis
T6048	20672-20681	UBERON:0007376	denotes	epidermal
T6049	20785-20794	UBERON:0000922	denotes	embryonic
T6050	20795-20801	UBERON:0002067	denotes	dermis
T6051	20849-20858	UBERON:0000922	denotes	embryonic
T6052	20874-20881	UBERON:0000922	denotes	embryos
T6053	20895-20900	UBERON:0000180	denotes	flank
T6054	21005-21009	UBERON:0001037	denotes	hair
T6055	21016-21022	UBERON:0000473	denotes	testis
T6056	21062-21066	SO:0000704	denotes	gene
T6057	21062-21077	GO:0010467	denotes	gene expression
T6058	21092-21105	GO:0097617	denotes	hybridization
T6059	21175-21180	UBERON:0000180	denotes	flank
T6060	21259-21264	UBERON:0000180	denotes	flank
T6061	21289-21299	UBERON:0000924	denotes	ectodermal
T6062	21363-21370	UBERON:0003082	denotes	myotome
T6063	22262-22271	UBERON:0000922	denotes	embryonic
T6064	22304-22308	UBERON:0001037	denotes	hair
T6065	22334-22340	UBERON:0000473	denotes	testis
T6066	22370-22374	UBERON:0001037	denotes	hair
T6067	22409-22413	UBERON:0001037	denotes	hair
T6068	22458-22462	UBERON:0001037	denotes	hair
T6069	22491-22496	UBERON:0000180	denotes	flank
T6070	22533-22537	UBERON:0001037	denotes	hair
T6071	22574-22578	UBERON:0001037	denotes	hair
T6072	22639-22644	UBERON:0000180	denotes	flank
T6073	22684-22688	UBERON:0001037	denotes	hair
T6074	22750-22755	UBERON:0001037	denotes	hairs
T6075	22797-22803	UBERON:0000479	denotes	tissue
T6076	22850-22859	GO:0010467	denotes	expressed
T6077	22860-22865	PR:000016145	denotes	Tbx15
T6078	22874-22880	PR:000004372	denotes	Agouti
T6079	22888-22893	UBERON:0000180	denotes	flank
T6080	22901-22910	GO:0010467	denotes	expressed
T6081	22916-22921	SO:0000704	denotes	genes
T6082	23031-23041	GO:0010467	denotes	expression
T6083	23063-23068	PR:000016145	denotes	Tbx15
T6084	23073-23079	PR:000004372	denotes	Agouti
T6085	23169-23185	GO:0043588	denotes	skin development
T6086	23199-23209	GO:0010467	denotes	expression
T6087	23213-23218	PR:000016145	denotes	Tbx15
T6728	23305-23312	CHEBI:26130	denotes	Pigment
T6729	23362-23378	UBERON:0015178	denotes	Somitic Frontier
T6730	23383-23393	UBERON:0000924	denotes	ectodermal
T6731	23442-23451	UBERON:0000922	denotes	embryonic
T6732	23452-23458	UBERON:0001137	denotes	dorsum
T6733	23463-23472	UBERON:0000922	denotes	embryonic
T6734	23473-23478	UBERON:0000180	denotes	flank
T6735	23510-23520	NCBITaxon:7742	denotes	vertebrate
T6736	23521-23528	UBERON:0000922	denotes	embryos
T6737	23643-23649	UBERON:0002067	denotes	dermis
T6738	23663-23679	UBERON:0003077	denotes	somitic mesoderm
T6739	23684-23690	UBERON:0002067	denotes	dermis
T6740	23704-23726	UBERON:0003081	denotes	lateral plate mesoderm
T6741	23760-23776	UBERON:0015178	denotes	somitic frontier
T6742	23932-23941	NCBITaxon:40674	denotes	mammalian
T6743	23942-23949	UBERON:0000922	denotes	embryos
T6744	23951-23957	UBERON:0002329	denotes	somite
T6745	23963-23976	UBERON:0003081	denotes	lateral plate
T6746	23985-23993	UBERON:0000926	denotes	mesoderm
T6747	24028-24034	UBERON:0002067	denotes	dermis
T6748	24061-24065	UBERON:0002101	denotes	limb
T6749	24066-24075	UBERON:0000309	denotes	body wall
T6750	24210-24220	UBERON:0000924	denotes	ectodermal
T6751	24318-24324	UBERON:0002067	denotes	dermis
T6752	24338-24360	UBERON:0003081	denotes	lateral plate mesoderm
T6753	24383-24392	SO:0000902	denotes	transgene
T6754	24407-24412	PR:000008703	denotes	Hoxb6
T6755	24413-24421	SO:0000167	denotes	promoter
T6756	24524-24533	GO:0007565	denotes	gestation
T6757	24534-24541	UBERON:0000922	denotes	embryos
T6758	24560-24565	PR:000008703	denotes	Hoxb6
T6759	24570-24579	SO:0000902	denotes	transgene
T6760	24593-24597	PR:000033987	denotes	lacZ
T6761	24607-24611	SO:0000704	denotes	gene
T6762	24635-24640	CHEBI:75055	denotes	X-Gal
T6763	24653-24675	UBERON:0003081	denotes	lateral plate mesoderm
T6764	24684-24707	UBERON:0003077	denotes	somite-derived mesoderm
T6765	24715-24720	UBERON:0002100	denotes	trunk
T6766	24782-24789	NCBITaxon:33208	denotes	animals
T6767	24826-24831	CHEBI:75055	denotes	X-Gal
T6768	24858-24871	UBERON:0003081	denotes	lateral plate
T6769	24880-24886	UBERON:0002067	denotes	dermis
T6770	24994-24998	NCBITaxon:10088	denotes	mice
T6771	25012-25023	CHEBI:81393	denotes	pheomelanin
T6772	25153-25162	CHEBI:24009	denotes	eumelanin
T6773	25167-25173	UBERON:0002329	denotes	somite
T6774	25182-25188	UBERON:0002067	denotes	dermis
T6775	25354-25367	UBERON:0003081	denotes	lateral plate
T6776	25373-25379	UBERON:0002329	denotes	somite
T6777	25388-25394	UBERON:0002067	denotes	dermis
T6778	26492-26496	UBERON:0002101	denotes	limb
T6779	26497-26506	UBERON:0000309	denotes	body wall
T6780	26585-26589	UBERON:0002101	denotes	limb
T6781	26690-26694	UBERON:0002101	denotes	limb
T6782	26696-26706	PR:000007070	denotes	Engrailed1
T6783	26708-26711	PR:000007070	denotes	En1
T6784	26714-26719	PR:000017448	denotes	Wnt7a
T6785	26725-26730	PR:000009871	denotes	Lmx1b
T6786	26781-26791	GO:0010467	denotes	expression
T6787	26862-26865	PR:000007070	denotes	En1
T6788	26881-26890	GO:0010467	denotes	expressed
T6789	26909-26914	UBERON:0000180	denotes	flank
T6790	26937-26946	UBERON:0000916	denotes	abdominal
T6791	26978-26989	UBERON:0001049	denotes	neural tube
T6792	26991-27016	UBERON:0003077	denotes	somite-derived mesenchyme
T6793	27026-27043	UBERON:0017648	denotes	ventral body wall
T6794	27077-27087	GO:0097617	denotes	hybridized
T6795	27093-27098	PR:000016145	denotes	Tbx15
T6796	27138-27143	UBERON:0000180	denotes	flank
T6797	27264-27286	UBERON:0003081	denotes	lateral plate mesoderm
T6798	27350-27366	UBERON:0015178	denotes	somitic frontier
T5280	14909-14919	GO:0010467	denotes	Expression
R2276	T3409	T3408	_lexicallyChainedTo	skin,area of
R3086	T4445	T4444	_lexicallyChainedTo	exons,portions of
R3660	T5293	T5292	_lexicallyChainedTo	head,mesenchymal tissues of
R3661	T5294	T5292	_lexicallyChainedTo	trunk,mesenchymal tissues of
R3662	T5295	T5292	_lexicallyChainedTo	limbs,mesenchymal tissues of

2_test

Id	Subject	Object	Predicate	Lexical cue
14737183-5956248-84902989	3594-3598	5956248	denotes	1966
14737183-13654621-84902990	5550-5554	13654621	denotes	1959
14737183-13654621-84902991	6352-6356	13654621	denotes	1959
14737183-24539711-84902992	11163-11167	24539711	denotes	1951
14737183-13654621-84902993	11175-11179	13654621	denotes	1959
14737183-489953-84902994	11197-11201	489953	denotes	1979
14737183-9693034-84902995	11651-11655	9693034	denotes	1998
14737183-9693034-84902996	12729-12733	9693034	denotes	1998
14737183-9503012-84902997	12945-12949	9503012	denotes	1998
14737183-9693034-84902998	13065-13069	9693034	denotes	1998
14737183-12175500-84902999	13087-13091	12175500	denotes	2002
14737183-1376319-84903000	13459-13463	1376319	denotes	1992
14737183-9693034-84903001	14976-14980	9693034	denotes	1998
14737183-781177-84903002	20459-20463	781177	denotes	1976
14737183-11089928-84903003	21400-21404	11089928	denotes	2000
14737183-11023864-84903004	21430-21434	11023864	denotes	2000
14737183-11401392-84903005	21448-21452	11401392	denotes	2001
14737183-12586060-84903006	21472-21476	12586060	denotes	2003
14737183-12559495-84903007	21493-21497	12559495	denotes	2003
14737183-11023864-84903008	23803-23807	11023864	denotes	2000
14737183-11401392-84903009	23821-23825	11401392	denotes	2001
14737183-12586060-84903010	23845-23849	12586060	denotes	2003
14737183-12559495-84903011	23866-23870	12559495	denotes	2003
14737183-10686603-84903012	24478-24482	10686603	denotes	2000
14737183-10686603-84903013	24514-24518	10686603	denotes	2000
14737183-9916792-84903014	24621-24625	9916792	denotes	1999
14737183-12560810-84903015	26855-26859	12560810	denotes	2003
T2876	3594-3598	5956248	denotes	1966
T29139	5550-5554	13654621	denotes	1959
T31415	6352-6356	13654621	denotes	1959
T49936	11163-11167	24539711	denotes	1951
T45512	11175-11179	13654621	denotes	1959
T81011	11197-11201	489953	denotes	1979
T15709	11651-11655	9693034	denotes	1998
T43472	12729-12733	9693034	denotes	1998
T40911	12945-12949	9503012	denotes	1998
T49725	13065-13069	9693034	denotes	1998
T90945	13087-13091	12175500	denotes	2002
T8080	13459-13463	1376319	denotes	1992
T27645	14976-14980	9693034	denotes	1998
T67049	20459-20463	781177	denotes	1976
T39522	21400-21404	11089928	denotes	2000
T71980	21430-21434	11023864	denotes	2000
T14086	21448-21452	11401392	denotes	2001
T24851	21472-21476	12586060	denotes	2003
T13078	21493-21497	12559495	denotes	2003
T16217	23803-23807	11023864	denotes	2000
T27994	23821-23825	11401392	denotes	2001
T19501	23845-23849	12586060	denotes	2003
T25180	23866-23870	12559495	denotes	2003
T74039	24478-24482	10686603	denotes	2000
T14949	24514-24518	10686603	denotes	2000
T41736	24621-24625	9916792	denotes	1999
T17681	26855-26859	12560810	denotes	2003

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T2428	50-54	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	Skin
T2429	97-101	UBERON:0001037	denotes	hair
T2430	158-162	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T2431	228-232	UBERON:0001037	denotes	hair
T2432	257-261	UBERON:0001037	denotes	hair
T2433	272-276	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T2434	329-341	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T2435	389-403	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T2436	413-420	CHEBI_EXT:26130	denotes	pigment
T2437	413-426	CL:0000147	denotes	pigment cells
T2438	421-426	CL_GO_EXT:cell	denotes	cells
T2439	451-458	CHEBI_EXT:26130	denotes	pigment
T2440	474-482	GO_EXT:reaction_or_response	denotes	response
T2441	486-496	GO:0010467	denotes	expression
T2442	500-506	PR_EXT:000004372	denotes	Agouti
T2443	531-535	UBERON:0001037	denotes	hair
T2444	545-552	NCBITaxon:33208	denotes	animals
T2445	764-768	NCBITaxon:10088	denotes	mice
T2446	782-788	PR_EXT:000004372	denotes	Agouti
T2447	789-798	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T2448	833-837	UBERON:0001037	denotes	hair
T2449	959-966	CHEBI_EXT:26130	denotes	pigment
T2450	989-993	NCBITaxon:10088	denotes	mice
T2451	1039-1043	UBERON:0001037	denotes	hair
T2452	1054-1058	UBERON:0001037	denotes	hair
T2453	1119-1125	UBERON:0001137	denotes	dorsum
T2454	1129-1136	UBERON:0013235	denotes	ventrum
T2455	1150-1155	UBERON:0000180	denotes	flank
T2456	1156-1161	UBERON:0001037	denotes	hairs
T2457	1173-1177	NCBITaxon:10088	denotes	mice
T2458	1241-1252	CHEBI:81393	denotes	pheomelanin
T2459	1308-1312	UBERON:0001037	denotes	hair
T2460	1352-1356	UBERON:0001037	denotes	hair
T2461	1402-1414	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T2462	1434-1440	PR_EXT:000004372	denotes	Agouti
T2463	1441-1449	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T2464	1460-1464	UBERON:0001037	denotes	hair
T2465	1460-1470	GO:0042633	denotes	hair-cycle
T2466	1539-1543	UBERON:0001037	denotes	hair
T2467	1555-1559	NCBITaxon:10088	denotes	mice
T2468	1673-1677	UBERON:0001037	denotes	hair
T2469	1689-1696	NCBITaxon:33208	denotes	animals
T2470	1725-1731	PR_EXT:000004372	denotes	Agouti
T2471	1732-1740	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T2472	1782-1786	UBERON_EXT:body	denotes	body
T2473	1876-1880	UBERON:0001037	denotes	hair
T2474	1963-1967	UBERON:0001037	denotes	hair
T2475	1963-1974	GO:0042633	denotes	hair cycles
T2476	1997-2001	UBERON:0001037	denotes	hair
T2477	2045-2052	CHEBI_EXT:26130	denotes	pigment
T2478	2078-2082	NCBITaxon:10088	denotes	mice
T2479	3249-3253	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T2480	3305-3309	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T2481	3317-3322	GO:0007567	denotes	natal
T2482	3353-3367	UBERON:0002073	denotes	hair follicles
T2483	3416-3430	UBERON:0002073	denotes	hair follicles
T2484	3478-3484	UBERON_EXT:skin_or_dermis	denotes	dermal
T2485	3532-3536	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T2486	3643-3647	UBERON:0001037	denotes	hair
T2487	3673-3678	UBERON:0001137	denotes	dorsa
T2488	3683-3689	UBERON:0013235	denotes	ventra
T2489	3693-3698	UBERON:0007023	denotes	adult
T2490	3699-3703	NCBITaxon:10088	denotes	mice
T2491	3727-3731	NCBITaxon:10088	denotes	mice
T2492	3788-3793	UBERON:0001037	denotes	hairs
T2493	3795-3802	UBERON:0010513	denotes	zigzags
T2494	3816-3821	UBERON:0001037	denotes	hairs
T2495	3823-3831	UBERON:0010510	denotes	auchenes
T2496	3833-3837	UBERON:0010511	denotes	awls
T2497	3843-3854	UBERON:0010512	denotes	guard hairs
T2498	3859-3865	UBERON:0001137	denotes	dorsum
T2499	3878-3885	UBERON:0013235	denotes	ventrum
T2500	3941-3945	UBERON:0001037	denotes	hair
T2501	3976-3980	NCBITaxon:10088	denotes	mice
T2502	4038-4050	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T2503	4060-4064	NCBITaxon:10088	denotes	mice
T2504	4091-4098	CHEBI_EXT:26130	denotes	pigment
T2505	4143-4153	GO:0010467	denotes	expression
T2506	4157-4163	PR_EXT:000004372	denotes	Agouti
T2507	4169-4176	NCBITaxon:33208	denotes	animals
T2508	4194-4198	SO_EXT:sequence_nullness	denotes	null
T2509	4199-4205	SO_EXT:0001023	denotes	allele
T2510	4209-4215	PR_EXT:000004372	denotes	Agouti
T2511	4254-4259	UBERON:0001037	denotes	hairs
T2512	4278-4285	CHEBI:25179	denotes	melanin
T2513	4298-4303	UBERON:0001037	denotes	hairs
T2514	4355-4359	UBERON:0010166	denotes	coat
T2515	4379-4383	CHEBI:49168	denotes	DOPA
T2516	4412-4422	GO_PR_EXT:monophenol_monooxygenase_or_tyrosinase	denotes	tyrosinase
T2517	4491-4497	UBERON:0002067	denotes	dermis
T2518	4527-4531	NCBITaxon:10088	denotes	mice
T2519	4558-4562	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T2520	4574-4578	NCBITaxon:10088	denotes	mice
T2521	4623-4627	CHEBI:49168	denotes	DOPA
T2522	4694-4701	CHEBI:25179	denotes	melanin
T2523	4723-4727	NCBITaxon:10088	denotes	mice
T2524	4733-4747	GO_EXT:negative_regulation	denotes	downregulation
T2525	4751-4761	GO_PR_EXT:monophenol_monooxygenase_or_tyrosinase	denotes	tyrosinase
T2526	4782-4788	PR_EXT:000004372	denotes	Agouti
T2527	4790-4797	CHEBI:25179	denotes	Melanin
T2528	4820-4825	UBERON:0001037	denotes	hairs
T2529	4875-4882	CHEBI_EXT:26130	denotes	pigment
T2530	4875-4888	CL:0000147	denotes	pigment cells
T2531	4883-4888	CL_GO_EXT:cell	denotes	cells
T2532	4899-4909	UBERON_EXT:follicle	denotes	follicular
T2533	4963-4967	UBERON:0001037	denotes	hair
T2534	4968-4975	CHEBI_EXT:26130	denotes	pigment
T2535	4993-4997	NCBITaxon:10088	denotes	mice
T2536	5026-5030	UBERON:0001037	denotes	hair
T2537	5026-5037	GO:0042633	denotes	hair cycles
T2538	5043-5052	UBERON:0000113	denotes	adulthood
T2539	5065-5069	UBERON:0001037	denotes	hair
T2540	5089-5093	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T2541	5175-5179	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T2542	5196-5203	CHEBI_EXT:26130	denotes	pigment
T2543	5233-5239	PR_EXT:000004372	denotes	Agouti
T2544	5240-5248	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T2545	5266-5270	UBERON:0001037	denotes	hair
T2546	5298-5305	CHEBI:25179	denotes	melanin
T3424	5334-5338	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	Skin
T3425	5364-5367	UBERON:0001690	denotes	ear
T3426	5368-5376	SO_EXT:sequence_alteration_entity_or_process	denotes	Mutation
T3427	5404-5416	UBERON_EXT:face_or_skull	denotes	craniofacial
T3428	5436-5439	UBERON:0001690	denotes	ear
T3429	5455-5463	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T3430	5467-5472	NCBITaxon:10088	denotes	mouse
T3431	5473-5483	GO_SO_EXT:chromosome	denotes	Chromosome
T3432	5500-5506	SO_EXT:0001023	denotes	allele
T3433	5588-5596	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T3434	5717-5729	UBERON_EXT:face_or_skull	denotes	craniofacial
T3435	5791-5798	NCBITaxon:33208	denotes	animals
T3436	5824-5828	UBERON:0000970	denotes	eyes
T3437	5836-5854	UBERON:0001819	denotes	palpebral fissures
T3438	5864-5869	UBERON:0000004	denotes	nasal
T3439	5892-5897	UBERON:0003129	denotes	skull
T3440	5999-6003	UBERON:0001690	denotes	ears
T3441	6036-6039	UBERON:0001690	denotes	ear
T3442	6061-6067	SO_EXT:0001023	denotes	allele
T3443	6092-6099	CHEBI_EXT:26130	denotes	pigment
T3444	6182-6189	SO_EXT:0000704	denotes	genetic
T3445	6209-6210	PR_EXT:000004372	denotes	A
T3446	6230-6235	UBERON:0000916	denotes	belly
T3447	6236-6240	UBERON:0001037	denotes	hair
T3448	6264-6268	UBERON:0011270	denotes	back
T3449	6269-6273	UBERON:0001037	denotes	hair
T3450	6279-6284	UBERON:0000916	denotes	belly
T3451	6285-6289	UBERON:0001037	denotes	hair
T3452	6330-6334	UBERON_EXT:body	denotes	body
T3453	6339-6343	UBERON:0001456	denotes	face
T3454	6384-6391	CHEBI_EXT:26130	denotes	pigment
T3455	6438-6442	NCBITaxon:10088	denotes	mice
T3456	6465-6471	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3457	6472-6479	NCBITaxon:33208	denotes	animals
T3458	6608-6613	UBERON:0001037	denotes	hairs
T3459	6687-6691	UBERON:0002101	denotes	limb
T3460	6692-6701	UBERON:0000309	denotes	body wall
T3461	6838-6842	NCBITaxon:10088	denotes	mice
T3462	6879-6884	UBERON:0001037	denotes	hairs
T3463	6930-6934	NCBITaxon:10088	denotes	mice
T3464	6980-6986	UBERON:2001463	denotes	stripe
T3465	6997-7002	UBERON:0000180	denotes	flank
T3466	7026-7030	NCBITaxon:10088	denotes	mice
T3467	7117-7122	UBERON:0000180	denotes	flank
T3468	7137-7146	CHEBI:24009	denotes	eumelanic
T3469	7218-7222	UBERON_EXT:body	denotes	body
T3470	7242-7248	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3471	7264-7270	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3472	7271-7278	NCBITaxon:33208	denotes	animals
T3473	7302-7306	UBERON_EXT:body	denotes	body
T3474	7355-7361	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3475	7362-7369	NCBITaxon:33208	denotes	animals
T3476	7523-7529	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3477	7554-7560	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3478	7561-7568	NCBITaxon:33208	denotes	animals
T3479	7641-7645	UBERON_EXT:body	denotes	body
T3480	7661-7666	UBERON:0002101	denotes	limbs
T3481	7675-7682	UBERON:1000019	denotes	cranium
T3482	7696-7703	UBERON:0006378	denotes	whisker
T3483	7704-7707	UBERON:2001977	denotes	pad
T3484	9121-9125	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T3485	9150-9157	CHEBI_EXT:26130	denotes	pigment
T3486	9201-9205	UBERON:0001037	denotes	hair
T3487	9217-9229	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T3488	9310-9314	UBERON:0001037	denotes	hair
T3489	9330-9336	UBERON:0001137	denotes	dorsum
T3490	9341-9348	UBERON:0013235	denotes	ventrum
T3491	9355-9361	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3492	9369-9375	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3493	9376-9383	NCBITaxon:33208	denotes	animals
T3494	9403-9407	UBERON_EXT:body	denotes	body
T3495	9431-9435	UBERON:0001037	denotes	hair
T3496	9516-9523	NCBITaxon:33208	denotes	animals
T3497	9532-9536	UBERON_EXT:body	denotes	body
T3498	9556-9564	UBERON:0004288	denotes	skeletal
T3499	9595-9599	UBERON:0010166	denotes	coat
T3500	9668-9676	PATO_UBERON_EXT:neonate_or_newborn	denotes	neonates
T3501	9733-9738	GO:0007567	denotes	birth
T3502	9772-9783	GO:0042438	denotes	melanogenic
T3503	9815-9819	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T3504	9848-9859	CL:0000541	denotes	melanoblast
T3505	9860-9869	GO_EXT:biological_movement_or_translocation_process	denotes	migration
T3506	9879-9891	UBERON:0002342	denotes	neural crest
T3507	9952-9962	CL:0000148	denotes	melanocyte
T3508	9963-9978	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T3509	9983-9990	CHEBI_EXT:26130	denotes	pigment
T3510	9983-10000	GO:0046148	denotes	pigment synthesis
T3511	10006-10010	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T3512	10020-10028	PATO_UBERON_EXT:neonate_or_newborn	denotes	neonates
T3513	10068-10074	UBERON:0001137	denotes	dorsum
T3514	10098-10106	PATO_UBERON_EXT:neonate_or_newborn	denotes	neonates
T3515	10112-10119	_FRAGMENT	denotes	area of
T3516	10125-10129	UBERON:0000014	denotes	skin
T3517	10173-10178	UBERON:0002101	denotes	limbs
T3518	10216-10225	CHEBI:24009	denotes	eumelanin
T3519	10244-10249	UBERON:0007023	denotes	adult
T3520	10250-10257	NCBITaxon:33208	denotes	animals
T3521	10331-10371	GO:0009953	denotes	establishment of dorsoventral patterning
T3522	10379-10383	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T3523	10379-10395	GO:0043588	denotes	skin development
T3524	10546-10550	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T3525	10565-10575	CL:0000148	denotes	melanocyte
T3526	10576-10591	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T3527	10606-10617	CHEBI:81393	denotes	pheomelanin
T3528	10673-10677	UBERON:0001037	denotes	hair
T3529	10678-10684	GO_EXT:biological_growth_entity_or_process	denotes	growth
T3530	10690-10697	UBERON:0013235	denotes	ventrum
T3531	10701-10707	UBERON:0001137	denotes	dorsum
T3532	10733-10737	SO_EXT:0000704	denotes	gene
T3533	10756-10761	PR_EXT:000016145	denotes	Tbx15
T3534	10775-10784	GO:0010467	denotes	expressed
T4501	10923-10930	SO_EXT:sequence_cloning_process	denotes	Cloning
T4502	10951-10957	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T4503	11006-11009	UBERON:0001690	denotes	ear
T4504	11010-11016	SO_EXT:0001023	denotes	allele
T4505	11028-11034	SO_EXT:0001023	denotes	allele
T4506	11078-11088	GO_SO_EXT:chromosome	denotes	Chromosome
T4507	11262-11266	NCBITaxon:10088	denotes	mice
T4508	11379-11388	NCBITaxon:2	denotes	bacterial
T4509	11379-11410	SO_EXT:0000153	denotes	bacterial artificial chromosome
T4510	11400-11410	GO_SO_EXT:chromosome	denotes	chromosome
T4511	11412-11415	SO_EXT:0000153	denotes	BAC
T4512	11417-11423	SO_EXT:0000149	denotes	contig
T4513	11439-11446	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T4514	11457-11458	CHEBI_SO_EXT:base	denotes	b
T4515	11487-11492	SO_EXT:0000704	denotes	genes
T4516	11504-11509	PR_EXT:000016145	denotes	Tbx15
T4517	11537-11542	PR_EXT:000016145	denotes	Tbx15
T4518	11577-11585	UBERON:0004288	denotes	skeletal
T4519	11676-11685	UBERON:0000922	denotes	embryonic
T4520	11686-11696	GO:0010467	denotes	expression
T4521	11704-11716	UBERON_EXT:face_or_skull	denotes	craniofacial
T4522	11739-11744	UBERON:0002101	denotes	limbs
T4523	12687-12695	SO_EXT:biological_sequence	denotes	sequence
T4524	12763-12768	NCBITaxon:10088	denotes	mouse
T4525	12769-12775	SO_EXT:0001026	denotes	genome
T4526	12776-12784	SO_EXT:biological_sequence	denotes	sequence
T4527	12800-12811	_FRAGMENT	denotes	portions of
T4528	12826-12831	SO_EXT:0000852	denotes	exons
T4529	12820-12825	PR_EXT:000016145	denotes	Tbx15
T4530	12868-12879	SO_EXT:genomic_DNA	denotes	genomic DNA
T4531	12876-12879	CHEBI_SO_EXT:DNA	denotes	DNA
T4532	12890-12894	SO_EXT:0000704	denotes	gene
T4533	12924-12928	PR_EXT:000016145	denotes	Tbx8
T4534	12974-12979	PR_EXT:000016145	denotes	Tbx14
T4535	13021-13031	NCBITaxon:7742	denotes	vertebrate
T4536	13032-13039	SO_EXT:0001026	denotes	genomes
T4537	13043-13048	PR_EXT:000016145	denotes	Tbx15
T4538	13111-13119	SO_EXT:biological_sequence	denotes	sequence
T4539	13130-13131	CHEBI_SO_EXT:base	denotes	b
T4540	13173-13184	SO_EXT:genomic_DNA	denotes	genomic DNA
T4541	13181-13184	CHEBI_SO_EXT:DNA	denotes	DNA
T4542	13207-13212	NCBITaxon:10088	denotes	mouse
T4543	13213-13219	SO_EXT:0001026	denotes	genome
T4544	13220-13228	SO_EXT:biological_sequence	denotes	sequence
T4545	13251-13252	CHEBI_SO_EXT:base	denotes	b
T4546	13253-13261	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T4547	13280-13285	PR_EXT:000016145	denotes	Tbx15
T4548	13286-13292	SO_EXT:0000188	denotes	intron
T4549	13303-13304	CHEBI_SO_EXT:base	denotes	b
T4550	13305-13315	SO_EXT:sequence_downstreamness	denotes	downstream
T4551	13323-13338	GO:0043631	denotes	polyadenylation
T4552	13323-13347	SO_EXT:0000610	denotes	polyadenylation sequence
T4553	13375-13394	CHEBI:17369	denotes	mannose-6-phosphate
T4554	13395-13403	GO_EXT:0004872	denotes	receptor
T4555	13404-13414	SO_EXT:0000336	denotes	pseudogene
T4556	13421-13423	SO_EXT:0000336	denotes	ps
T4557	13509-13515	SO_EXT:sequence_fusion_entity_or_process	denotes	fusion
T4558	13516-13526	SO_EXT:0000673	denotes	transcript
T4559	13549-13559	GO_SO_EXT:chromosome	denotes	chromosome
T4560	13591-13599	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T4561	13623-13634	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T4562	13635-13642	SO_EXT:sequence_coding_function	denotes	encoded
T4563	13646-13651	PR_EXT:000016145	denotes	Tbx15
T4564	13673-13676	CHEBI_SO_EXT:DNA	denotes	DNA
T4565	13677-13684	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T4566	13685-13691	SO_EXT:0000417	denotes	domain
T4567	13698-13699	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4568	13700-13707	NCBITaxon:33208	denotes	animals
T4569	13757-13764	NCBITaxon:33208	denotes	animals
T4570	13813-13819	SO_EXT:0001023	denotes	allele
T4571	13850-13852	SO_EXT:0000336	denotes	ps
T4572	13863-13868	SO_EXT:0000704	denotes	genes
T4573	13872-13883	SO_EXT:0000673	denotes	transcripts
T4574	13916-13917	CHEBI_SO_EXT:base	denotes	b
T4575	13918-13926	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T4576	13949-13956	SO_EXT:sequence_cloning_process	denotes	cloning
T4577	14021-14029	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T4578	14033-14038	PR_EXT:000016145	denotes	Tbx15
T4579	14042-14046	SO_EXT:0000704	denotes	gene
T4580	14060-14069	UBERON:0000922	denotes	embryonic
T4581	14060-14080	CL:0002322	denotes	embryonic stem cells
T4582	14075-14080	CL_GO_EXT:cell	denotes	cells
T4583	14095-14101	SO_EXT:0001023	denotes	allele
T4584	14103-14108	PR_EXT:000016145	denotes	Tbx15
T4585	14108-14112	PR_EXT:000033987	denotes	LacZ
T4586	14125-14129	SO_EXT:0000243	denotes	IRES
T4587	14130-14134	PR_EXT:000033987	denotes	LacZ
T4588	14135-14138	CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase	denotes	neo
T4589	14139-14143	SO_EXT:cDNA	denotes	cDNA
T4590	14144-14152	SO_EXT:0005853	denotes	cassette
T4591	14171-14189	SO_EXT:0000236	denotes	open reading frame
T4592	14193-14198	SO_EXT:0000360	denotes	codon
T4593	14222-14228	SO_EXT:0000417	denotes	domain
T4594	14242-14249	NCBITaxon:33208	denotes	Animals
T4595	14280-14286	SO_EXT:0001023	denotes	allele
T4596	14330-14338	UBERON:0004288	denotes	skeletal
T4597	14355-14359	UBERON:0001037	denotes	hair
T4598	14384-14389	PR_EXT:000016145	denotes	Tbx15
T4599	14389-14393	PR_EXT:000033987	denotes	LacZ
T4600	14394-14399	PR_EXT:000016145	denotes	Tbx15
T4601	14399-14403	PR_EXT:000033987	denotes	LacZ
T4602	14446-14450	UBERON_EXT:body	denotes	body
T4603	14472-14484	UBERON_EXT:face_or_skull	denotes	craniofacial
T4604	14542-14547	PR_EXT:000016145	denotes	Tbx15
T4605	14547-14551	PR_EXT:000033987	denotes	LacZ
T4606	14610-14617	NCBITaxon:33208	denotes	animals
T4607	14668-14680	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T4608	14709-14714	UBERON:0000180	denotes	flank
T4609	14751-14758	NCBITaxon:33208	denotes	animals
T4610	14815-14825	CHEBI_EXT:26130	denotes	pigmentary
T4611	14830-14842	UBERON_EXT:face_or_skull	denotes	craniofacial
T4612	14901-14906	PR_EXT:000016145	denotes	Tbx15
T5363	14909-14919	GO:0010467	denotes	Expression
T5364	14923-14928	PR_EXT:000016145	denotes	Tbx15
T5365	14933-14939	PR_EXT:000004372	denotes	Agouti
T5366	15008-15021	GO:0097617	denotes	hybridization
T5367	15032-15042	GO:0010467	denotes	expression
T5368	15046-15051	PR_EXT:000016145	denotes	Tbx15
T5369	15087-15096	UBERON:0004347	denotes	limb buds
T5370	15117-15133	UBERON:0002539	denotes	branchial arches
T5371	15135-15141	UBERON:0000180	denotes	flanks
T5372	15147-15159	UBERON_EXT:face_or_skull	denotes	craniofacial
T5373	15230-15240	GO:0097617	denotes	hybridized
T5374	15243-15248	PR_EXT:000016145	denotes	Tbx15
T5375	15249-15253	CHEBI_SO_EXT:mRNA	denotes	mRNA
T5376	15254-15259	CHEBI_SO_EXT:molecular_probe	denotes	probe
T5377	15317-15327	GO:0010467	denotes	expression
T5378	15340-15362	_FRAGMENT	denotes	mesenchymal tissues of
T5379	15367-15371	UBERON:0005253	denotes	head
T5380	15373-15378	UBERON:0005256	denotes	trunk
T5381	15395-15400	UBERON:0009749	denotes	limbs
T5382	15451-15456	UBERON:0003129	denotes	skull
T5383	15458-15476	UBERON:0002413	denotes	cervical vertebrae
T5384	15482-15486	UBERON:0002101	denotes	limb
T5385	15514-15518	NCBITaxon:10088	denotes	mice
T5386	15548-15551	UBERON:0001690	denotes	ear
T5387	15552-15558	SO_EXT:0001023	denotes	allele
T5388	16423-16432	UBERON:0000922	denotes	embryonic
T5389	16433-16438	UBERON:0000180	denotes	flank
T5390	16439-16449	GO:0010467	denotes	expression
T5391	16505-16509	NCBITaxon:10088	denotes	mice
T5392	16522-16531	UBERON:0000916	denotes	abdominal
T5393	16611-16621	GO:0010467	denotes	expression
T5394	16641-16651	UBERON:0003104	denotes	mesenchyme
T5395	16768-16774	UBERON:0002067	denotes	dermis
T5396	16805-16821	UBERON:0007529	denotes	loose mesenchyme
T5397	16830-16839	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	cutaneous
T5398	16840-16852	UBERON:0018260	denotes	muscle layer
T5399	16854-16859	PR_EXT:000016145	denotes	Tbx15
T5400	16863-16872	GO:0010467	denotes	expressed
T5401	16922-16939	UBERON:0002378	denotes	abdominal muscles
T5402	16949-16953	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T5403	16955-16960	PR_EXT:000016145	denotes	Tbx15
T5404	16964-16973	GO:0010467	denotes	expressed
T5405	17001-17005	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T5406	17044-17050	UBERON:0002067	denotes	dermis
T5407	17066-17072	UBERON_EXT:skin_or_dermis	denotes	dermal
T5408	17073-17080	UBERON:0005933	denotes	sheaths
T5409	17084-17098	UBERON:0002073	denotes	hair follicles
T5410	17106-17116	GO:0010467	denotes	expression
T5411	17146-17161	UBERON:0000412	denotes	dermal papillae
T5412	17146-17167	CL:0000346	denotes	dermal papillae cells
T5413	17162-17167	CL_GO_EXT:cell	denotes	cells
T5414	17205-17211	PR_EXT:000004372	denotes	Agouti
T5415	17215-17222	CHEBI_EXT:26130	denotes	pigment
T5416	17255-17260	GO:0007567	denotes	natal
T5417	17261-17265	UBERON:0001037	denotes	hair
T5418	17266-17272	GO_EXT:biological_growth_entity_or_process	denotes	growth
T5419	17295-17302	SO_EXT:0001060	denotes	isoform
T5420	17306-17312	PR_EXT:000004372	denotes	Agouti
T5421	17316-17325	GO:0010467	denotes	expressed
T5422	17340-17344	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T5423	17395-17405	GO:0097617	denotes	hybridized
T5424	17411-17417	CHEBI_SO_EXT:molecular_probe	denotes	probes
T5425	17422-17427	PR_EXT:000016145	denotes	Tbx15
T5426	17432-17438	PR_EXT:000004372	denotes	Agouti
T5427	17490-17500	GO:0010467	denotes	expression
T5428	17504-17510	PR_EXT:000004372	denotes	Agouti
T5429	17522-17526	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T5430	17531-17541	GO:0010467	denotes	expression
T5431	17545-17550	PR_EXT:000016145	denotes	Tbx15
T5432	17561-17565	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T5433	17607-17617	GO:0010467	denotes	expression
T5434	17655-17660	PR_EXT:000016145	denotes	Tbx15
T5435	17661-17671	GO:0010467	denotes	expression
T5436	17720-17726	PR_EXT:000004372	denotes	Agouti
T5437	17727-17737	GO:0010467	denotes	expression
T5438	18303-18313	GO:0010467	denotes	expression
T5439	18317-18323	PR_EXT:000004372	denotes	Agouti
T5440	18356-18362	SO_EXT:sequence_altered_entity	denotes	mutant
T5441	18367-18376	SO_EXT:sequence_unaltered_entity	denotes	nonmutant
T5442	18473-18479	PR_EXT:000004372	denotes	Agouti
T5444	18535-18542	UBERON:0000922	denotes	embryos
T5445	18564-18568	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T5446	18570-18580	GO:0010467	denotes	expression
T5447	18584-18590	PR_EXT:000004372	denotes	Agouti
T5448	18628-18635	NCBITaxon:33208	denotes	animals
T5449	18697-18703	UBERON:0002067	denotes	dermis
T5450	18708-18723	UBERON:0000412	denotes	dermal papillae
T5451	18708-18729	CL:0000346	denotes	dermal papillae cells
T5452	18724-18729	CL_GO_EXT:cell	denotes	cells
T5453	18759-18771	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T5454	18793-18797	NCBITaxon:10088	denotes	mice
T5455	18857-18863	PR_EXT:000004372	denotes	Agouti
T5456	18864-18874	GO:0010467	denotes	expression
T5457	18881-18886	GO:0007567	denotes	birth
T5458	18888-18897	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterned
T5459	18898-18908	GO:0010467	denotes	expression
T5460	18912-18917	PR_EXT:000016145	denotes	Tbx15
T5461	18922-18928	PR_EXT:000004372	denotes	Agouti
T5462	19008-19013	PR_EXT:000016145	denotes	Tbx15
T5463	19028-19038	GO:0010467	denotes	expression
T5464	19042-19048	PR_EXT:000004372	denotes	Agouti
T6088	19719-19728	UBERON:0000922	denotes	Embryonic
T6089	19729-19734	PR_EXT:000016145	denotes	Tbx15
T6090	19735-19745	GO:0010467	denotes	Expression
T6091	19768-19780	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	Pigmentation
T6092	19869-19879	GO:0010467	denotes	expression
T6093	19883-19888	PR_EXT:000016145	denotes	Tbx15
T6094	19896-19905	UBERON:0000922	denotes	embryonic
T6095	19913-19918	UBERON:0000180	denotes	flank
T6096	19978-19984	UBERON:0002067	denotes	dermis
T6097	20011-20018	CHEBI_EXT:26130	denotes	pigment
T6098	20065-20071	PR_EXT:000004372	denotes	Agouti
T6099	20072-20079	SO_EXT:0001060	denotes	isoform
T6100	20183-20192	UBERON:0000922	denotes	embryonic
T6101	20193-20197	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6102	20268-20277	UBERON:0000922	denotes	embryonic
T6103	20278-20282	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6104	20339-20343	UBERON:0001037	denotes	hair
T6105	20365-20375	GO:0010467	denotes	expression
T6106	20379-20384	PR_EXT:000016145	denotes	Tbx15
T6107	20389-20395	PR_EXT:000004372	denotes	Agouti
T6108	20496-20500	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6109	20521-20528	UBERON:0000922	denotes	embryos
T6110	20560-20564	UBERON:0001037	denotes	hair
T6111	20603-20609	UBERON:0000473	denotes	testis
T6112	20665-20671	UBERON_EXT:skin_or_dermis	denotes	dermal
T6113	20672-20681	UBERON:0007376	denotes	epidermal
T6114	20785-20794	UBERON:0000922	denotes	embryonic
T6115	20795-20801	UBERON:0002067	denotes	dermis
T6116	20849-20858	UBERON:0000922	denotes	embryonic
T6117	20859-20863	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6118	20874-20881	UBERON:0000922	denotes	embryos
T6119	20895-20900	UBERON:0000180	denotes	flank
T6120	21005-21009	UBERON:0001037	denotes	hair
T6121	21016-21022	UBERON:0000473	denotes	testis
T6122	21062-21066	SO_EXT:0000704	denotes	gene
T6123	21062-21077	GO:0010467	denotes	gene expression
T6124	21092-21105	GO:0097617	denotes	hybridization
T6125	21175-21180	UBERON:0000180	denotes	flank
T6126	21194-21198	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6127	21220-21224	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6128	21259-21264	UBERON:0000180	denotes	flank
T6129	21265-21269	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6130	21289-21299	UBERON:0000924	denotes	ectodermal
T6131	21363-21370	UBERON:0003082	denotes	myotome
T6132	22262-22271	UBERON:0000922	denotes	embryonic
T6133	22280-22284	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6134	22304-22308	UBERON:0001037	denotes	hair
T6135	22334-22340	UBERON:0000473	denotes	testis
T6136	22370-22374	UBERON:0001037	denotes	hair
T6137	22384-22388	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6138	22409-22413	UBERON:0001037	denotes	hair
T6139	22434-22438	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6140	22458-22462	UBERON:0001037	denotes	hair
T6141	22491-22496	UBERON:0000180	denotes	flank
T6142	22497-22501	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6143	22533-22537	UBERON:0001037	denotes	hair
T6144	22574-22578	UBERON:0001037	denotes	hair
T6145	22639-22644	UBERON:0000180	denotes	flank
T6146	22684-22688	UBERON:0001037	denotes	hair
T6147	22750-22755	UBERON:0001037	denotes	hairs
T6148	22797-22803	UBERON:0000479	denotes	tissue
T6149	22850-22859	GO:0010467	denotes	expressed
T6150	22860-22865	PR_EXT:000016145	denotes	Tbx15
T6151	22874-22880	PR_EXT:000004372	denotes	Agouti
T6152	22888-22893	UBERON:0000180	denotes	flank
T6153	22901-22910	GO:0010467	denotes	expressed
T6154	22916-22921	SO_EXT:0000704	denotes	genes
T6155	22976-22988	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T6156	23021-23030	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterned
T6157	23031-23041	GO:0010467	denotes	expression
T6158	23063-23068	PR_EXT:000016145	denotes	Tbx15
T6159	23073-23079	PR_EXT:000004372	denotes	Agouti
T6160	23169-23173	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6161	23169-23185	GO:0043588	denotes	skin development
T6162	23199-23209	GO:0010467	denotes	expression
T6163	23213-23218	PR_EXT:000016145	denotes	Tbx15
T6164	23265-23269	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6799	23305-23312	CHEBI_EXT:26130	denotes	Pigment
T6800	23362-23378	UBERON:0015178	denotes	Somitic Frontier
T6801	23383-23393	UBERON:0000924	denotes	ectodermal
T6802	23442-23451	UBERON:0000922	denotes	embryonic
T6803	23452-23458	UBERON:0001137	denotes	dorsum
T6804	23463-23472	UBERON:0000922	denotes	embryonic
T6805	23473-23478	UBERON:0000180	denotes	flank
T6806	23510-23520	NCBITaxon:7742	denotes	vertebrate
T6807	23521-23528	UBERON:0000922	denotes	embryos
T6808	23533-23537	CL_GO_EXT:cell	denotes	cell
T6809	23573-23578	NCBITaxon_UBERON_EXT:chick	denotes	chick
T6810	23643-23649	UBERON:0002067	denotes	dermis
T6811	23663-23679	UBERON:0003077	denotes	somitic mesoderm
T6812	23684-23690	UBERON:0002067	denotes	dermis
T6813	23704-23726	UBERON:0003081	denotes	lateral plate mesoderm
T6814	23760-23776	UBERON:0015178	denotes	somitic frontier
T6815	23932-23941	NCBITaxon:40674	denotes	mammalian
T6816	23942-23949	UBERON:0000922	denotes	embryos
T6817	23951-23957	UBERON:0002329	denotes	somite
T6818	23963-23976	UBERON:0003081	denotes	lateral plate
T6819	23985-23993	UBERON:0000926	denotes	mesoderm
T6820	24028-24034	UBERON:0002067	denotes	dermis
T6821	24061-24065	UBERON:0002101	denotes	limb
T6822	24066-24075	UBERON:0000309	denotes	body wall
T6823	24168-24180	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T6824	24210-24220	UBERON:0000924	denotes	ectodermal
T6825	24292-24304	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T6826	24318-24324	UBERON:0002067	denotes	dermis
T6827	24338-24360	UBERON:0003081	denotes	lateral plate mesoderm
T6828	24383-24392	SO_EXT:0000902	denotes	transgene
T6829	24407-24412	PR_EXT:000008703	denotes	Hoxb6
T6830	24413-24421	SO_EXT:0000167	denotes	promoter
T6831	24524-24533	GO:0007565	denotes	gestation
T6832	24534-24541	UBERON:0000922	denotes	embryos
T6833	24560-24565	PR_EXT:000008703	denotes	Hoxb6
T6834	24570-24579	SO_EXT:0000902	denotes	transgene
T6835	24593-24597	PR_EXT:000033987	denotes	lacZ
T6836	24607-24611	SO_EXT:0000704	denotes	gene
T6837	24635-24640	CHEBI:75055	denotes	X-Gal
T6838	24653-24675	UBERON:0003081	denotes	lateral plate mesoderm
T6839	24684-24707	UBERON:0003077	denotes	somite-derived mesoderm
T6840	24715-24720	UBERON:0002100	denotes	trunk
T6841	24737-24741	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6842	24773-24781	PATO_UBERON_EXT:neonate_or_newborn	denotes	neonatal
T6843	24782-24789	NCBITaxon:33208	denotes	animals
T6844	24826-24831	CHEBI:75055	denotes	X-Gal
T6845	24858-24871	UBERON:0003081	denotes	lateral plate
T6846	24880-24886	UBERON:0002067	denotes	dermis
T6847	24994-24998	NCBITaxon:10088	denotes	mice
T6848	25012-25023	CHEBI:81393	denotes	pheomelanin
T6849	25059-25063	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6850	25115-25119	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6851	25153-25162	CHEBI:24009	denotes	eumelanin
T6852	25167-25173	UBERON:0002329	denotes	somite
T6853	25182-25188	UBERON:0002067	denotes	dermis
T6854	25264-25276	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T6855	25354-25367	UBERON:0003081	denotes	lateral plate
T6856	25373-25379	UBERON:0002329	denotes	somite
T6857	25388-25394	UBERON:0002067	denotes	dermis
T6858	26444-26456	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T6859	26492-26496	UBERON:0002101	denotes	limb
T6860	26497-26506	UBERON:0000309	denotes	body wall
T6861	26585-26589	UBERON:0002101	denotes	limb
T6862	26590-26600	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterning
T6863	26649-26661	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T6864	26690-26694	UBERON:0002101	denotes	limb
T6865	26696-26706	PR_EXT:000007070	denotes	Engrailed1
T6866	26708-26711	PR_EXT:000007070	denotes	En1
T6867	26714-26719	PR_EXT:000017448	denotes	Wnt7a
T6868	26725-26730	PR_EXT:000009871	denotes	Lmx1b
T6869	26781-26791	GO:0010467	denotes	expression
T6870	26862-26865	PR_EXT:000007070	denotes	En1
T6871	26881-26890	GO:0010467	denotes	expressed
T6872	26909-26914	UBERON:0000180	denotes	flank
T6873	26937-26946	UBERON:0000916	denotes	abdominal
T6874	26978-26989	UBERON:0001049	denotes	neural tube
T6875	26991-27016	UBERON:0003077	denotes	somite-derived mesenchyme
T6876	27026-27043	UBERON:0017648	denotes	ventral body wall
T6877	27077-27087	GO:0097617	denotes	hybridized
T6878	27093-27098	PR_EXT:000016145	denotes	Tbx15
T6879	27138-27143	UBERON:0000180	denotes	flank
T6880	27226-27238	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T6881	27264-27286	UBERON:0003081	denotes	lateral plate mesoderm
T6882	27350-27366	UBERON:0015178	denotes	somitic frontier
T5443	18480-18490	GO:0010467	denotes	expression
R2277	T3516	T3515	_lexicallyChainedTo	skin,area of
R3087	T4528	T4527	_lexicallyChainedTo	exons,portions of
R3663	T5379	T5378	_lexicallyChainedTo	head,mesenchymal tissues of
R3664	T5380	T5378	_lexicallyChainedTo	trunk,mesenchymal tissues of
R3665	T5381	T5378	_lexicallyChainedTo	limbs,mesenchymal tissues of

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