PMC:314463 / 36755-55075 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T7563	11-18	JJ	denotes	Several
T7564	19-28	NNS	denotes	mutations
T7565	49-59	VBN	denotes	identified
T7566	29-32	CC	denotes	and
T7567	33-38	NNS	denotes	genes
T7568	39-43	VBP	denotes	have
T7569	44-48	VBN	denotes	been
T7570	60-64	WDT	denotes	that
T7571	65-71	VBP	denotes	affect
T7572	72-75	DT	denotes	the
T7573	76-83	NN	denotes	pattern
T7574	84-86	IN	denotes	of
T7575	87-91	NN	denotes	hair
T7576	92-100	NN	denotes	follicle
T7577	101-112	NN	denotes	development
T7578	112-114	,	denotes	,
T7579	114-117	CC	denotes	but
T7580	118-123	NN	denotes	Tbx15
T7581	124-126	VBZ	denotes	is
T7582	127-130	DT	denotes	the
T7583	136-140	NN	denotes	gene
T7584	131-135	JJ	denotes	only
T7585	141-143	IN	denotes	of
T7586	153-156	VBP	denotes	are
T7587	144-149	WDT	denotes	which
T7588	150-152	PRP	denotes	we
T7589	157-162	JJ	denotes	aware
T7590	163-167	WDT	denotes	that
T7591	168-175	VBZ	denotes	affects
T7592	176-179	DT	denotes	the
T7593	180-187	NN	denotes	pattern
T7594	188-190	IN	denotes	of
T7595	191-195	NN	denotes	hair
T7596	196-208	NN	denotes	pigmentation
T7597	209-211	IN	denotes	in
T7598	212-221	JJ	denotes	different
T7599	227-234	NNS	denotes	regions
T7600	222-226	NN	denotes	body
T7601	234-235	.	denotes	.
T7602	235-499	sentence	denotes	Ventral areas that normally produce yellow hair in the trunk, limbs, and craniofacial regions are expanded in deH/deH mice and, in the trunk at least, represent inappropriate dorsal expression of an Agouti mRNA isoform that is normally restricted to ventral skin.
T7603	236-243	JJ	denotes	Ventral
T7604	244-249	NNS	denotes	areas
T7605	334-342	VBN	denotes	expanded
T7606	250-254	WDT	denotes	that
T7607	264-271	VBP	denotes	produce
T7608	255-263	RB	denotes	normally
T7609	272-278	JJ	denotes	yellow
T7610	279-283	NN	denotes	hair
T7611	284-286	IN	denotes	in
T7612	287-290	DT	denotes	the
T7613	291-296	NN	denotes	trunk
T7614	296-298	,	denotes	,
T7615	298-303	NNS	denotes	limbs
T7616	303-305	,	denotes	,
T7617	305-308	CC	denotes	and
T7618	309-321	JJ	denotes	craniofacial
T7619	322-329	NNS	denotes	regions
T7620	330-333	VBP	denotes	are
T7621	343-345	IN	denotes	in
T7622	346-349	NN	denotes	deH
T7623	350-353	NN	denotes	deH
T7624	349-350	SYM	denotes	/
T7625	354-358	NNS	denotes	mice
T7626	359-362	CC	denotes	and
T7627	362-364	,	denotes	,
T7628	364-366	IN	denotes	in
T7629	387-396	VBP	denotes	represent
T7630	367-370	DT	denotes	the
T7631	371-376	NN	denotes	trunk
T7632	377-379	RB	denotes	at
T7633	380-385	RBS	denotes	least
T7634	385-387	,	denotes	,
T7635	397-410	JJ	denotes	inappropriate
T7636	418-428	NN	denotes	expression
T7637	411-417	JJ	denotes	dorsal
T7638	429-431	IN	denotes	of
T7639	432-434	DT	denotes	an
T7640	447-454	NN	denotes	isoform
T7641	435-441	NN	denotes	Agouti
T7642	442-446	NN	denotes	mRNA
T7643	455-459	WDT	denotes	that
T7644	472-482	VBN	denotes	restricted
T7645	460-462	VBZ	denotes	is
T7646	463-471	RB	denotes	normally
T7647	483-485	IN	denotes	to
T7648	486-493	JJ	denotes	ventral
T7649	494-498	NN	denotes	skin
T7650	498-499	.	denotes	.
T7651	499-730	sentence	denotes	The deH allele is caused by a large deletion that removes most of the Tbx15 coding sequence, but the pleiotropic phenotype is caused by a simple loss of function for Tbx15 rather than a dominant-negative or contiguous gene effect.
T7652	500-503	DT	denotes	The
T7653	508-514	NN	denotes	allele
T7654	504-507	NN	denotes	deH
T7655	518-524	VBN	denotes	caused
T7656	515-517	VBZ	denotes	is
T7657	525-527	IN	denotes	by
T7658	528-529	DT	denotes	a
T7659	536-544	NN	denotes	deletion
T7660	530-535	JJ	denotes	large
T7661	545-549	WDT	denotes	that
T7662	550-557	VBZ	denotes	removes
T7663	558-562	JJS	denotes	most
T7664	563-565	IN	denotes	of
T7665	566-569	DT	denotes	the
T7666	583-591	NN	denotes	sequence
T7667	570-575	NN	denotes	Tbx15
T7668	576-582	NN	denotes	coding
T7669	591-593	,	denotes	,
T7670	593-596	CC	denotes	but
T7671	597-600	DT	denotes	the
T7672	613-622	NN	denotes	phenotype
T7673	601-612	JJ	denotes	pleiotropic
T7674	626-632	VBN	denotes	caused
T7675	623-625	VBZ	denotes	is
T7676	633-635	IN	denotes	by
T7677	636-637	DT	denotes	a
T7678	645-649	NN	denotes	loss
T7679	638-644	JJ	denotes	simple
T7680	650-652	IN	denotes	of
T7681	653-661	NN	denotes	function
T7682	662-665	IN	denotes	for
T7683	666-671	NN	denotes	Tbx15
T7684	672-678	RB	denotes	rather
T7685	679-683	IN	denotes	than
T7686	684-685	DT	denotes	a
T7687	723-729	NN	denotes	effect
T7688	686-694	JJ	denotes	dominant
T7689	695-703	JJ	denotes	negative
T7690	694-695	HYPH	denotes	-
T7691	704-706	CC	denotes	or
T7692	707-717	JJ	denotes	contiguous
T7693	718-722	NN	denotes	gene
T7694	729-730	.	denotes	.
T7695	730-992	sentence	denotes	In particular, there is no heterozygous phenotype, no other genes lie within or close to the deletion breakpoints, and the expression pattern of Tbx15 is consistent with the spectrum of phenotypic abnormalities in both the original de allele and the deH allele.
T7696	731-733	IN	denotes	In
T7697	752-754	VBZ	denotes	is
T7698	734-744	JJ	denotes	particular
T7699	744-746	,	denotes	,
T7700	746-751	EX	denotes	there
T7701	755-757	DT	denotes	no
T7702	771-780	NN	denotes	phenotype
T7703	758-770	JJ	denotes	heterozygous
T7704	780-782	,	denotes	,
T7705	782-784	DT	denotes	no
T7706	791-796	NNS	denotes	genes
T7707	785-790	JJ	denotes	other
T7708	797-800	VBP	denotes	lie
T7709	801-807	IN	denotes	within
T7710	808-810	CC	denotes	or
T7711	811-816	RB	denotes	close
T7712	833-844	NNS	denotes	breakpoints
T7713	817-819	IN	denotes	to
T7714	820-823	DT	denotes	the
T7715	824-832	NN	denotes	deletion
T7716	844-846	,	denotes	,
T7717	846-849	CC	denotes	and
T7718	850-853	DT	denotes	the
T7719	865-872	NN	denotes	pattern
T7720	854-864	NN	denotes	expression
T7721	882-884	VBZ	denotes	is
T7722	873-875	IN	denotes	of
T7723	876-881	NN	denotes	Tbx15
T7724	885-895	JJ	denotes	consistent
T7725	896-900	IN	denotes	with
T7726	901-904	DT	denotes	the
T7727	905-913	NN	denotes	spectrum
T7728	914-916	IN	denotes	of
T7729	917-927	JJ	denotes	phenotypic
T7730	928-941	NNS	denotes	abnormalities
T7731	942-944	IN	denotes	in
T7732	945-949	CC	denotes	both
T7733	966-972	NN	denotes	allele
T7734	950-953	DT	denotes	the
T7735	954-962	JJ	denotes	original
T7736	963-965	NN	denotes	de
T7737	973-976	CC	denotes	and
T7738	977-980	DT	denotes	the
T7739	985-991	NN	denotes	allele
T7740	981-984	NN	denotes	deH
T7741	991-992	.	denotes	.
T7742	992-1056	sentence	denotes	Finally, a Tbx15 targeted allele has the same phenotype as deH.
T7743	993-1000	RB	denotes	Finally
T7744	1026-1029	VBZ	denotes	has
T7745	1000-1002	,	denotes	,
T7746	1002-1003	DT	denotes	a
T7747	1019-1025	NN	denotes	allele
T7748	1004-1009	NN	denotes	Tbx15
T7749	1010-1018	VBN	denotes	targeted
T7750	1030-1033	DT	denotes	the
T7751	1039-1048	NN	denotes	phenotype
T7752	1034-1038	JJ	denotes	same
T7753	1049-1051	IN	denotes	as
T7754	1052-1055	NN	denotes	deH
T7755	1055-1056	.	denotes	.
T7756	1057-1254	sentence	denotes	Our results suggest that patterned expression of Tbx15 provides an instructional cue required to establish the future identity of dorsal dermis with regard to pigmentary and hair length patterning.
T7757	1057-1060	PRP$	denotes	Our
T7758	1061-1068	NNS	denotes	results
T7759	1069-1076	VBP	denotes	suggest
T7760	1077-1081	IN	denotes	that
T7761	1112-1120	VBZ	denotes	provides
T7762	1082-1091	VBN	denotes	patterned
T7763	1092-1102	NN	denotes	expression
T7764	1103-1105	IN	denotes	of
T7765	1106-1111	NN	denotes	Tbx15
T7766	1121-1123	DT	denotes	an
T7767	1138-1141	NN	denotes	cue
T7768	1124-1137	JJ	denotes	instructional
T7769	1142-1150	VBN	denotes	required
T7770	1151-1153	TO	denotes	to
T7771	1154-1163	VB	denotes	establish
T7772	1164-1167	DT	denotes	the
T7773	1175-1183	NN	denotes	identity
T7774	1168-1174	JJ	denotes	future
T7775	1184-1186	IN	denotes	of
T7776	1187-1193	JJ	denotes	dorsal
T7777	1194-1200	NN	denotes	dermis
T7778	1201-1205	IN	denotes	with
T7779	1206-1212	NN	denotes	regard
T7780	1213-1215	IN	denotes	to
T7781	1216-1226	JJ	denotes	pigmentary
T7782	1243-1253	NN	denotes	patterning
T7783	1227-1230	CC	denotes	and
T7784	1231-1235	NN	denotes	hair
T7785	1236-1242	NN	denotes	length
T7786	1253-1254	.	denotes	.
T7787	1254-1433	sentence	denotes	The ventral edge of Tbx15 expression in the developing flank does not correspond to a known lineage compartment, but, like limb development, occurs within lateral plate mesoderm.
T7788	1255-1258	DT	denotes	The
T7789	1267-1271	NN	denotes	edge
T7790	1259-1266	JJ	denotes	ventral
T7791	1325-1335	VB	denotes	correspond
T7792	1272-1274	IN	denotes	of
T7793	1275-1280	NN	denotes	Tbx15
T7794	1281-1291	NN	denotes	expression
T7795	1292-1294	IN	denotes	in
T7796	1295-1298	DT	denotes	the
T7797	1310-1315	NN	denotes	flank
T7798	1299-1309	VBG	denotes	developing
T7799	1316-1320	VBZ	denotes	does
T7800	1321-1324	RB	denotes	not
T7801	1336-1338	IN	denotes	to
T7802	1339-1340	DT	denotes	a
T7803	1355-1366	NN	denotes	compartment
T7804	1341-1346	VBN	denotes	known
T7805	1347-1354	NN	denotes	lineage
T7806	1366-1368	,	denotes	,
T7807	1368-1371	CC	denotes	but
T7808	1371-1373	,	denotes	,
T7809	1373-1377	IN	denotes	like
T7810	1396-1402	VBZ	denotes	occurs
T7811	1378-1382	NN	denotes	limb
T7812	1383-1394	NN	denotes	development
T7813	1394-1396	,	denotes	,
T7814	1403-1409	IN	denotes	within
T7815	1410-1417	JJ	denotes	lateral
T7816	1418-1423	NN	denotes	plate
T7817	1424-1432	NN	denotes	mesoderm
T7818	1432-1433	.	denotes	.
T7819	1433-1651	sentence	denotes	These findings represent a novel role for T-box gene action in embryonic development and provide evidence for a previously unappreciated complexity to acquisition of dorsoventral positional identity in mammalian skin.
T7820	1434-1439	DT	denotes	These
T7821	1440-1448	NNS	denotes	findings
T7822	1449-1458	VBP	denotes	represent
T7823	1459-1460	DT	denotes	a
T7824	1467-1471	NN	denotes	role
T7825	1461-1466	JJ	denotes	novel
T7826	1472-1475	IN	denotes	for
T7827	1476-1477	NN	denotes	T
T7828	1478-1481	NN	denotes	box
T7829	1477-1478	HYPH	denotes	-
T7830	1487-1493	NN	denotes	action
T7831	1482-1486	NN	denotes	gene
T7832	1494-1496	IN	denotes	in
T7833	1497-1506	JJ	denotes	embryonic
T7834	1507-1518	NN	denotes	development
T7835	1519-1522	CC	denotes	and
T7836	1523-1530	VBP	denotes	provide
T7837	1531-1539	NN	denotes	evidence
T7838	1540-1543	IN	denotes	for
T7839	1544-1545	DT	denotes	a
T7840	1571-1581	NN	denotes	complexity
T7841	1546-1556	RB	denotes	previously
T7842	1557-1570	JJ	denotes	unappreciated
T7843	1582-1584	IN	denotes	to
T7844	1585-1596	NN	denotes	acquisition
T7845	1597-1599	IN	denotes	of
T7846	1600-1612	JJ	denotes	dorsoventral
T7847	1624-1632	NN	denotes	identity
T7848	1613-1623	JJ	denotes	positional
T7849	1633-1635	IN	denotes	in
T7850	1636-1645	JJ	denotes	mammalian
T7851	1646-1650	NN	denotes	skin
T7852	1650-1651	.	denotes	.
T7946	1653-1661	JJ	denotes	Distinct
T7947	1674-1681	NNS	denotes	Regions
T7948	1662-1673	JJ	denotes	Morphologic
T7949	1682-1691	VBP	denotes	Represent
T7950	1692-1695	DT	denotes	the
T7951	1696-1699	NN	denotes	Sum
T7952	1700-1702	IN	denotes	of
T7953	1703-1712	JJ	denotes	Different
T7954	1713-1722	NNS	denotes	Gradients
T7955	1722-1976	sentence	denotes	The visual boundary between dorsal and ventral skin in at/at mice is reminiscent of other systems in which adjacent compartments enforce a binary choice between alternative patterns of gene expression and cell fate (reviewed in Dahmann and Basler 1999).
T7956	1723-1726	DT	denotes	The
T7957	1734-1742	NN	denotes	boundary
T7958	1727-1733	JJ	denotes	visual
T7959	1789-1791	VBZ	denotes	is
T7960	1743-1750	IN	denotes	between
T7961	1751-1757	JJ	denotes	dorsal
T7962	1770-1774	NN	denotes	skin
T7963	1758-1761	CC	denotes	and
T7964	1762-1769	JJ	denotes	ventral
T7965	1775-1777	IN	denotes	in
T7966	1778-1780	NN	denotes	at
T7967	1781-1783	NN	denotes	at
T7968	1780-1781	SYM	denotes	/
T7969	1784-1788	NNS	denotes	mice
T7970	1792-1803	JJ	denotes	reminiscent
T7971	1804-1806	IN	denotes	of
T7972	1807-1812	JJ	denotes	other
T7973	1813-1820	NNS	denotes	systems
T7974	1821-1823	IN	denotes	in
T7975	1852-1859	VBP	denotes	enforce
T7976	1824-1829	WDT	denotes	which
T7977	1830-1838	JJ	denotes	adjacent
T7978	1839-1851	NNS	denotes	compartments
T7979	1860-1861	DT	denotes	a
T7980	1869-1875	NN	denotes	choice
T7981	1862-1868	JJ	denotes	binary
T7982	1876-1883	IN	denotes	between
T7983	1884-1895	JJ	denotes	alternative
T7984	1896-1904	NNS	denotes	patterns
T7985	1905-1907	IN	denotes	of
T7986	1908-1912	NN	denotes	gene
T7987	1913-1923	NN	denotes	expression
T7988	1924-1927	CC	denotes	and
T7989	1928-1932	NN	denotes	cell
T7990	1933-1937	NN	denotes	fate
T7991	1938-1939	-LRB-	denotes	(
T7992	1939-1947	VBN	denotes	reviewed
T7993	1948-1950	IN	denotes	in
T7994	1951-1958	NNP	denotes	Dahmann
T7995	1959-1962	CC	denotes	and
T7996	1963-1969	NNP	denotes	Basler
T7997	1970-1974	CD	denotes	1999
T7998	1974-1975	-RRB-	denotes	)
T7999	1975-1976	.	denotes	.
T8000	1976-2232	sentence	denotes	However, Agouti mRNA in both embryonic and postnatal skin is distributed along a gradient whose dorsal boundary is indistinct and overlaps with two additional gradients recognized by their effects on hair length and histochemical staining for melanocytes.
T8001	1977-1984	RB	denotes	However
T8002	2038-2049	VBN	denotes	distributed
T8003	1984-1986	,	denotes	,
T8004	1986-1992	NN	denotes	Agouti
T8005	1993-1997	NN	denotes	mRNA
T8006	1998-2000	IN	denotes	in
T8007	2001-2005	CC	denotes	both
T8008	2006-2015	JJ	denotes	embryonic
T8009	2030-2034	NN	denotes	skin
T8010	2016-2019	CC	denotes	and
T8011	2020-2029	JJ	denotes	postnatal
T8012	2035-2037	VBZ	denotes	is
T8013	2050-2055	IN	denotes	along
T8014	2056-2057	DT	denotes	a
T8015	2058-2066	NN	denotes	gradient
T8016	2067-2072	WP$	denotes	whose
T8017	2080-2088	NN	denotes	boundary
T8018	2073-2079	JJ	denotes	dorsal
T8019	2089-2091	VBZ	denotes	is
T8020	2092-2102	JJ	denotes	indistinct
T8021	2103-2106	CC	denotes	and
T8022	2107-2115	VBZ	denotes	overlaps
T8023	2116-2120	IN	denotes	with
T8024	2121-2124	CD	denotes	two
T8025	2136-2145	NNS	denotes	gradients
T8026	2125-2135	JJ	denotes	additional
T8027	2146-2156	VBN	denotes	recognized
T8028	2157-2159	IN	denotes	by
T8029	2160-2165	PRP$	denotes	their
T8030	2166-2173	NNS	denotes	effects
T8031	2174-2176	IN	denotes	on
T8032	2177-2181	NN	denotes	hair
T8033	2182-2188	NN	denotes	length
T8034	2189-2192	CC	denotes	and
T8035	2193-2206	JJ	denotes	histochemical
T8036	2207-2215	NN	denotes	staining
T8037	2216-2219	IN	denotes	for
T8038	2220-2231	NNS	denotes	melanocytes
T8039	2231-2232	.	denotes	.
T8040	2232-2401	sentence	denotes	The three gradients are close but not congruent, and it is their proximity that gives rise to the superficial distinction between dorsal and ventral skin of at/at mice.
T8041	2233-2236	DT	denotes	The
T8042	2243-2252	NNS	denotes	gradients
T8043	2237-2242	CD	denotes	three
T8044	2253-2256	VBP	denotes	are
T8045	2257-2262	JJ	denotes	close
T8046	2263-2266	CC	denotes	but
T8047	2267-2270	RB	denotes	not
T8048	2271-2280	JJ	denotes	congruent
T8049	2280-2282	,	denotes	,
T8050	2282-2285	CC	denotes	and
T8051	2286-2288	PRP	denotes	it
T8052	2289-2291	VBZ	denotes	is
T8053	2292-2297	PRP$	denotes	their
T8054	2298-2307	NN	denotes	proximity
T8055	2308-2312	WDT	denotes	that
T8056	2313-2318	VBZ	denotes	gives
T8057	2319-2323	NN	denotes	rise
T8058	2324-2326	IN	denotes	to
T8059	2327-2330	DT	denotes	the
T8060	2343-2354	NN	denotes	distinction
T8061	2331-2342	JJ	denotes	superficial
T8062	2355-2362	IN	denotes	between
T8063	2363-2369	JJ	denotes	dorsal
T8064	2382-2386	NN	denotes	skin
T8065	2370-2373	CC	denotes	and
T8066	2374-2381	JJ	denotes	ventral
T8067	2387-2389	IN	denotes	of
T8068	2390-2392	NN	denotes	at
T8069	2393-2395	NN	denotes	at
T8070	2392-2393	SYM	denotes	/
T8071	2396-2400	NNS	denotes	mice
T8072	2400-2401	.	denotes	.
T8073	2401-2589	sentence	denotes	Indeed, slight differences between the regions of transition for pigment-type switching and pigment content give rise to a subtle yellow stripe along the flank (see Figures 1, 2, and 9A).
T8074	2402-2408	RB	denotes	Indeed
T8075	2510-2514	VBP	denotes	give
T8076	2408-2410	,	denotes	,
T8077	2410-2416	JJ	denotes	slight
T8078	2417-2428	NNS	denotes	differences
T8079	2429-2436	IN	denotes	between
T8080	2437-2440	DT	denotes	the
T8081	2441-2448	NNS	denotes	regions
T8082	2449-2451	IN	denotes	of
T8083	2452-2462	NN	denotes	transition
T8084	2463-2466	IN	denotes	for
T8085	2467-2474	NN	denotes	pigment
T8086	2475-2479	NN	denotes	type
T8087	2474-2475	HYPH	denotes	-
T8088	2480-2489	NN	denotes	switching
T8089	2490-2493	CC	denotes	and
T8090	2494-2501	NN	denotes	pigment
T8091	2502-2509	NN	denotes	content
T8092	2515-2519	NN	denotes	rise
T8093	2520-2522	IN	denotes	to
T8094	2523-2524	DT	denotes	a
T8095	2539-2545	NN	denotes	stripe
T8096	2525-2531	JJ	denotes	subtle
T8097	2532-2538	JJ	denotes	yellow
T8098	2546-2551	IN	denotes	along
T8099	2552-2555	DT	denotes	the
T8100	2556-2561	NN	denotes	flank
T8101	2562-2563	-LRB-	denotes	(
T8102	2563-2566	VB	denotes	see
T8103	2567-2574	NNS	denotes	Figures
T8104	2575-2576	CD	denotes	1
T8105	2576-2578	,	denotes	,
T8106	2578-2579	CD	denotes	2
T8107	2579-2581	,	denotes	,
T8108	2581-2584	CC	denotes	and
T8109	2585-2587	CD	denotes	9A
T8110	2587-2588	-RRB-	denotes	)
T8111	2588-2589	.	denotes	.
T8112	2589-2855	sentence	denotes	Levels of Agouti mRNA remain high throughout the entire ventrum, but hair pigment content is reduced, giving rise to a cream-colored region in the ventrum that, depending on age and genetic backgrounds, may appear more or less distinct from the yellow flank stripe.
T8113	2590-2596	NNS	denotes	Levels
T8114	2612-2618	VBP	denotes	remain
T8115	2597-2599	IN	denotes	of
T8116	2600-2606	NN	denotes	Agouti
T8117	2607-2611	NN	denotes	mRNA
T8118	2619-2623	JJ	denotes	high
T8119	2624-2634	IN	denotes	throughout
T8120	2635-2638	DT	denotes	the
T8121	2646-2653	NN	denotes	ventrum
T8122	2639-2645	JJ	denotes	entire
T8123	2653-2655	,	denotes	,
T8124	2655-2658	CC	denotes	but
T8125	2659-2663	NN	denotes	hair
T8126	2672-2679	NN	denotes	content
T8127	2664-2671	NN	denotes	pigment
T8128	2683-2690	VBN	denotes	reduced
T8129	2680-2682	VBZ	denotes	is
T8130	2690-2692	,	denotes	,
T8131	2692-2698	VBG	denotes	giving
T8132	2699-2703	NN	denotes	rise
T8133	2704-2706	IN	denotes	to
T8134	2707-2708	DT	denotes	a
T8135	2723-2729	NN	denotes	region
T8136	2709-2714	NN	denotes	cream
T8137	2715-2722	VBN	denotes	colored
T8138	2714-2715	HYPH	denotes	-
T8139	2730-2732	IN	denotes	in
T8140	2733-2736	DT	denotes	the
T8141	2737-2744	NN	denotes	ventrum
T8142	2745-2749	WDT	denotes	that
T8143	2797-2803	VB	denotes	appear
T8144	2749-2751	,	denotes	,
T8145	2751-2760	VBG	denotes	depending
T8146	2761-2763	IN	denotes	on
T8147	2764-2767	NN	denotes	age
T8148	2768-2771	CC	denotes	and
T8149	2772-2779	JJ	denotes	genetic
T8150	2780-2791	NNS	denotes	backgrounds
T8151	2791-2793	,	denotes	,
T8152	2793-2796	MD	denotes	may
T8153	2804-2808	RBR	denotes	more
T8154	2817-2825	JJ	denotes	distinct
T8155	2809-2811	CC	denotes	or
T8156	2812-2816	RBR	denotes	less
T8157	2826-2830	IN	denotes	from
T8158	2831-2834	DT	denotes	the
T8159	2848-2854	NN	denotes	stripe
T8160	2835-2841	JJ	denotes	yellow
T8161	2842-2847	NN	denotes	flank
T8162	2854-2855	.	denotes	.
T8163	2855-4375	sentence	denotes	Figure 9 Model for Acquisition of Dorsoventral Patterning in the Trunk and the Role of Tbx15 (A) A tricolor pigmentation pattern is generated by the combination of distinct mechanisms that affect distribution of Agouti mRNA and histochemical staining for melanocytes; effects of the latter mechanism by itself are evident in ae/ae mice (see Figure 1). In at/at mice, reduced hair melanocyte activity and high levels of Agouti mRNA in the ventrum lead to a cream color; as melanocyte activity gradually increases towards the dorsum, a lateral stripe is apparent on the flank. The distributions of Agouti mRNA and histochemical staining for melanocytes are both affected by Tbx15 and are externally evident by a widening of the lateral stripe and an increased proportion of total skin occupied by the cream-colored area. (B) The lateral yellow stripe in at/at mice lies at the same level as the limb dorsoventral boundary. As described in the text, we propose that distinct dorsoventral compartments in ectoderm of the trunk provide an instructional cue to the mesoderm, leading to expression of Tbx15 in dorsal trunk mesenchyme and acquisition of dorsal dermis character. In the absence of Tbx15, dorsal mesenchyme assumes ventral characteristics instead. Loss of Tbx15 affects dorsoventral transitions of hair length, pigment content, and expression of the ventral-specific Agouti isoform; however, the former two effects are subtle and contribute little, if at all, to the abnormal pigmentation of adult deH/deH mice.
T8164	4112-4116	NN	denotes	Loss
T8165	4126-4133	VBZ	denotes	affects
T8166	4117-4119	IN	denotes	of
T8167	4120-4125	NN	denotes	Tbx15
T8168	4279-4282	VBP	denotes	are
T8169	4134-4146	JJ	denotes	dorsoventral
T8170	4147-4158	NNS	denotes	transitions
T8171	4159-4161	IN	denotes	of
T8172	4162-4166	NN	denotes	hair
T8173	4167-4173	NN	denotes	length
T8174	4173-4175	,	denotes	,
T8175	4175-4182	NN	denotes	pigment
T8176	4183-4190	NN	denotes	content
T8177	4190-4192	,	denotes	,
T8178	4192-4195	CC	denotes	and
T8179	4196-4206	NN	denotes	expression
T8180	4207-4209	IN	denotes	of
T8181	4210-4213	DT	denotes	the
T8182	4238-4245	NN	denotes	isoform
T8183	4214-4221	JJ	denotes	ventral
T8184	4222-4230	JJ	denotes	specific
T8185	4221-4222	HYPH	denotes	-
T8186	4231-4237	NN	denotes	Agouti
T8187	4245-4246	:	denotes	;
T8188	4247-4254	RB	denotes	however
T8189	4254-4256	,	denotes	,
T8190	4256-4259	DT	denotes	the
T8191	4271-4278	NNS	denotes	effects
T8192	4260-4266	JJ	denotes	former
T8193	4267-4270	CD	denotes	two
T8194	4283-4289	JJ	denotes	subtle
T8195	4290-4293	CC	denotes	and
T8196	4294-4304	VBP	denotes	contribute
T8197	4305-4311	JJ	denotes	little
T8198	4311-4313	,	denotes	,
T8199	4319-4322	RB	denotes	all
T8200	4313-4315	IN	denotes	if
T8201	4316-4318	RB	denotes	at
T8202	4322-4324	,	denotes	,
T8203	4324-4326	IN	denotes	to
T8204	4327-4330	DT	denotes	the
T8205	4340-4352	NN	denotes	pigmentation
T8206	4331-4339	JJ	denotes	abnormal
T8207	4353-4355	IN	denotes	of
T8208	4356-4361	JJ	denotes	adult
T8209	4370-4374	NNS	denotes	mice
T8210	4362-4365	NN	denotes	deH
T8211	4366-4369	NN	denotes	deH
T8212	4365-4366	SYM	denotes	/
T8213	4374-4375	.	denotes	.
T8214	4375-4586	sentence	denotes	Thus, despite the abnormal pattern of dark skin in neonatal deH/deH mice (e.g., Figure 2D), the most obvious feature in adults is dorsal displacement of the “boundary” between black and yellow hair (Figure 9A).
T8215	4376-4380	RB	denotes	Thus
T8216	4503-4505	VBZ	denotes	is
T8217	4380-4382	,	denotes	,
T8218	4382-4389	IN	denotes	despite
T8219	4390-4393	DT	denotes	the
T8220	4403-4410	NN	denotes	pattern
T8221	4394-4402	JJ	denotes	abnormal
T8222	4411-4413	IN	denotes	of
T8223	4414-4418	JJ	denotes	dark
T8224	4419-4423	NN	denotes	skin
T8225	4424-4426	IN	denotes	in
T8226	4427-4435	JJ	denotes	neonatal
T8227	4444-4448	NNS	denotes	mice
T8228	4436-4439	NN	denotes	deH
T8229	4440-4443	NN	denotes	deH
T8230	4439-4440	SYM	denotes	/
T8231	4449-4450	-LRB-	denotes	(
T8232	4456-4462	NN	denotes	Figure
T8233	4450-4454	FW	denotes	e.g.
T8234	4454-4456	,	denotes	,
T8235	4463-4465	CD	denotes	2D
T8236	4465-4466	-RRB-	denotes	)
T8237	4466-4468	,	denotes	,
T8238	4468-4471	DT	denotes	the
T8239	4485-4492	NN	denotes	feature
T8240	4472-4476	RBS	denotes	most
T8241	4477-4484	JJ	denotes	obvious
T8242	4493-4495	IN	denotes	in
T8243	4496-4502	NNS	denotes	adults
T8244	4506-4512	JJ	denotes	dorsal
T8245	4513-4525	NN	denotes	displacement
T8246	4526-4528	IN	denotes	of
T8247	4529-4532	DT	denotes	the
T8248	4534-4542	NN	denotes	boundary
T8249	4533-4534	``	denotes	“
T8250	4542-4543	''	denotes	”
T8251	4544-4551	IN	denotes	between
T8252	4552-4557	JJ	denotes	black
T8253	4569-4573	NN	denotes	hair
T8254	4558-4561	CC	denotes	and
T8255	4562-4568	JJ	denotes	yellow
T8256	4574-4575	-LRB-	denotes	(
T8257	4575-4581	NN	denotes	Figure
T8258	4582-4584	CD	denotes	9A
T8259	4584-4585	-RRB-	denotes	)
T8260	4585-4586	.	denotes	.
T8496	4588-4596	NN	denotes	Genetics
T8497	4597-4599	IN	denotes	of
T8498	4600-4605	NN	denotes	Tbx15
T8499	4605-4901	sentence	denotes	Named for the presence of a DNA-binding domain first identified in the mouse Brachyury gene (haploinsufficiency causes a short tail), T box–containing genes have been identified as developmental regulators in a wide spectrum of tissues and multicellular organisms (reviewed in Papaioannou 2001).
T8500	4606-4611	VBN	denotes	Named
T8501	4773-4783	VBN	denotes	identified
T8502	4612-4615	IN	denotes	for
T8503	4616-4619	DT	denotes	the
T8504	4620-4628	NN	denotes	presence
T8505	4629-4631	IN	denotes	of
T8506	4632-4633	DT	denotes	a
T8507	4646-4652	NN	denotes	domain
T8508	4634-4637	NN	denotes	DNA
T8509	4638-4645	VBG	denotes	binding
T8510	4637-4638	HYPH	denotes	-
T8511	4653-4658	RB	denotes	first
T8512	4659-4669	VBN	denotes	identified
T8513	4670-4672	IN	denotes	in
T8514	4673-4676	DT	denotes	the
T8515	4693-4697	NN	denotes	gene
T8516	4677-4682	NN	denotes	mouse
T8517	4683-4692	NN	denotes	Brachyury
T8518	4698-4699	-LRB-	denotes	(
T8519	4718-4724	VBZ	denotes	causes
T8520	4699-4717	NN	denotes	haploinsufficiency
T8521	4725-4726	DT	denotes	a
T8522	4733-4737	NN	denotes	tail
T8523	4727-4732	JJ	denotes	short
T8524	4737-4738	-RRB-	denotes	)
T8525	4738-4740	,	denotes	,
T8526	4740-4741	NN	denotes	T
T8527	4742-4745	NN	denotes	box
T8528	4746-4756	VBG	denotes	containing
T8529	4745-4746	HYPH	denotes	–
T8530	4757-4762	NNS	denotes	genes
T8531	4763-4767	VBP	denotes	have
T8532	4768-4772	VBN	denotes	been
T8533	4784-4786	IN	denotes	as
T8534	4787-4800	JJ	denotes	developmental
T8535	4801-4811	NNS	denotes	regulators
T8536	4812-4814	IN	denotes	in
T8537	4815-4816	DT	denotes	a
T8538	4822-4830	NN	denotes	spectrum
T8539	4817-4821	JJ	denotes	wide
T8540	4831-4833	IN	denotes	of
T8541	4834-4841	NNS	denotes	tissues
T8542	4842-4845	CC	denotes	and
T8543	4846-4859	JJ	denotes	multicellular
T8544	4860-4869	NNS	denotes	organisms
T8545	4870-4871	-LRB-	denotes	(
T8546	4871-4879	VBN	denotes	reviewed
T8547	4880-4882	IN	denotes	in
T8548	4883-4894	NNP	denotes	Papaioannou
T8549	4895-4899	CD	denotes	2001
T8550	4899-4900	-RRB-	denotes	)
T8551	4900-4901	.	denotes	.
T8552	4901-5123	sentence	denotes	The Tbx15 subfamily, which also includes Tbx18 and Tbx22, is likely to have arisen during early chordate evolution since there is a single gene in amphioxus but no obvious homolog in the fly genome (Ruvinsky et al. 2000).
T8553	4902-4905	DT	denotes	The
T8554	4912-4921	NN	denotes	subfamily
T8555	4906-4911	NN	denotes	Tbx15
T8556	4960-4962	VBZ	denotes	is
T8557	4921-4923	,	denotes	,
T8558	4923-4928	WDT	denotes	which
T8559	4934-4942	VBZ	denotes	includes
T8560	4929-4933	RB	denotes	also
T8561	4943-4948	NN	denotes	Tbx18
T8562	4949-4952	CC	denotes	and
T8563	4953-4958	NN	denotes	Tbx22
T8564	4958-4960	,	denotes	,
T8565	4963-4969	JJ	denotes	likely
T8566	4970-4972	TO	denotes	to
T8567	4978-4984	VBN	denotes	arisen
T8568	4973-4977	VB	denotes	have
T8569	4985-4991	IN	denotes	during
T8570	4992-4997	JJ	denotes	early
T8571	5007-5016	NN	denotes	evolution
T8572	4998-5006	NN	denotes	chordate
T8573	5017-5022	IN	denotes	since
T8574	5029-5031	VBZ	denotes	is
T8575	5023-5028	EX	denotes	there
T8576	5032-5033	DT	denotes	a
T8577	5041-5045	NN	denotes	gene
T8578	5034-5040	JJ	denotes	single
T8579	5046-5048	IN	denotes	in
T8580	5049-5058	NN	denotes	amphioxus
T8581	5059-5062	CC	denotes	but
T8582	5063-5065	DT	denotes	no
T8583	5074-5081	NN	denotes	homolog
T8584	5066-5073	JJ	denotes	obvious
T8585	5082-5084	IN	denotes	in
T8586	5085-5088	DT	denotes	the
T8587	5093-5099	NN	denotes	genome
T8588	5089-5092	NN	denotes	fly
T8589	5100-5101	-LRB-	denotes	(
T8590	5101-5109	NNP	denotes	Ruvinsky
T8591	5110-5112	FW	denotes	et
T8592	5113-5116	FW	denotes	al.
T8593	5117-5121	CD	denotes	2000
T8594	5121-5122	-RRB-	denotes	)
T8595	5122-5123	.	denotes	.
T8596	5123-5493	sentence	denotes	Consistent with this relationship, the three genes are expressed in partially overlapping patterns that include anterior somites (Tbx18 and Tbx22), limb mesenchyme (Tbx15 and Tbx18), and craniofacial mesenchyme (all three genes, Tbx15 more broadly than Tbx18 or Tbx22) (Agulnik et al. 1998; Kraus et al. 2001; Braybrook et al. 2002; Bush et al. 2002; Herr et al. 2003).
T8597	5124-5134	JJ	denotes	Consistent
T8598	5179-5188	VBN	denotes	expressed
T8599	5135-5139	IN	denotes	with
T8600	5140-5144	DT	denotes	this
T8601	5145-5157	NN	denotes	relationship
T8602	5157-5159	,	denotes	,
T8603	5159-5162	DT	denotes	the
T8604	5169-5174	NNS	denotes	genes
T8605	5163-5168	CD	denotes	three
T8606	5175-5178	VBP	denotes	are
T8607	5189-5191	IN	denotes	in
T8608	5192-5201	RB	denotes	partially
T8609	5202-5213	VBG	denotes	overlapping
T8610	5214-5222	NNS	denotes	patterns
T8611	5223-5227	WDT	denotes	that
T8612	5228-5235	VBP	denotes	include
T8613	5236-5244	JJ	denotes	anterior
T8614	5245-5252	NNS	denotes	somites
T8615	5253-5254	-LRB-	denotes	(
T8616	5254-5259	NN	denotes	Tbx18
T8617	5260-5263	CC	denotes	and
T8618	5264-5269	NN	denotes	Tbx22
T8619	5269-5270	-RRB-	denotes	)
T8620	5270-5272	,	denotes	,
T8621	5272-5276	NN	denotes	limb
T8622	5277-5287	NN	denotes	mesenchyme
T8623	5288-5289	-LRB-	denotes	(
T8624	5289-5294	NN	denotes	Tbx15
T8625	5295-5298	CC	denotes	and
T8626	5299-5304	NN	denotes	Tbx18
T8627	5304-5305	-RRB-	denotes	)
T8628	5305-5307	,	denotes	,
T8629	5307-5310	CC	denotes	and
T8630	5311-5323	JJ	denotes	craniofacial
T8631	5324-5334	NN	denotes	mesenchyme
T8632	5335-5336	-LRB-	denotes	(
T8633	5346-5351	NNS	denotes	genes
T8634	5336-5339	DT	denotes	all
T8635	5340-5345	CD	denotes	three
T8636	5351-5353	,	denotes	,
T8637	5353-5358	NN	denotes	Tbx15
T8638	5359-5363	RBR	denotes	more
T8639	5364-5371	RB	denotes	broadly
T8640	5372-5376	IN	denotes	than
T8641	5377-5382	NN	denotes	Tbx18
T8642	5383-5385	CC	denotes	or
T8643	5386-5391	NN	denotes	Tbx22
T8644	5391-5392	-RRB-	denotes	)
T8645	5393-5394	-LRB-	denotes	(
T8646	5394-5401	NNP	denotes	Agulnik
T8647	5402-5404	FW	denotes	et
T8648	5405-5408	FW	denotes	al.
T8649	5409-5413	CD	denotes	1998
T8650	5413-5414	:	denotes	;
T8651	5415-5420	NNP	denotes	Kraus
T8652	5421-5423	FW	denotes	et
T8653	5424-5427	FW	denotes	al.
T8654	5428-5432	CD	denotes	2001
T8655	5432-5433	:	denotes	;
T8656	5434-5443	NNP	denotes	Braybrook
T8657	5444-5446	FW	denotes	et
T8658	5447-5450	FW	denotes	al.
T8659	5451-5455	CD	denotes	2002
T8660	5455-5456	:	denotes	;
T8661	5457-5461	NNP	denotes	Bush
T8662	5462-5464	FW	denotes	et
T8663	5465-5468	FW	denotes	al.
T8664	5469-5473	CD	denotes	2002
T8665	5473-5474	:	denotes	;
T8666	5475-5479	NNP	denotes	Herr
T8667	5480-5482	FW	denotes	et
T8668	5483-5486	FW	denotes	al.
T8669	5487-5491	CD	denotes	2003
T8670	5491-5492	-RRB-	denotes	)
T8671	5492-5493	.	denotes	.
T8672	5493-5785	sentence	denotes	These observations suggest that an ancestral gene for Tbx15, Tbx18, and Tbx22 may have been important for craniofacial development in cephalochordates, with acquisition of additional expression patterns and developmental functions in the limb and the trunk during early vertebrate evolution.
T8673	5494-5499	DT	denotes	These
T8674	5500-5512	NNS	denotes	observations
T8675	5513-5520	VBP	denotes	suggest
T8676	5521-5525	IN	denotes	that
T8677	5581-5585	VBN	denotes	been
T8678	5526-5528	DT	denotes	an
T8679	5539-5543	NN	denotes	gene
T8680	5529-5538	JJ	denotes	ancestral
T8681	5544-5547	IN	denotes	for
T8682	5548-5553	NN	denotes	Tbx15
T8683	5553-5555	,	denotes	,
T8684	5555-5560	NN	denotes	Tbx18
T8685	5560-5562	,	denotes	,
T8686	5562-5565	CC	denotes	and
T8687	5566-5571	NN	denotes	Tbx22
T8688	5572-5575	MD	denotes	may
T8689	5576-5580	VB	denotes	have
T8690	5586-5595	JJ	denotes	important
T8691	5596-5599	IN	denotes	for
T8692	5600-5612	JJ	denotes	craniofacial
T8693	5613-5624	NN	denotes	development
T8694	5625-5627	IN	denotes	in
T8695	5628-5644	NNS	denotes	cephalochordates
T8696	5644-5646	,	denotes	,
T8697	5646-5650	IN	denotes	with
T8698	5651-5662	NN	denotes	acquisition
T8699	5663-5665	IN	denotes	of
T8700	5666-5676	JJ	denotes	additional
T8701	5688-5696	NNS	denotes	patterns
T8702	5677-5687	NN	denotes	expression
T8703	5697-5700	CC	denotes	and
T8704	5701-5714	JJ	denotes	developmental
T8705	5715-5724	NNS	denotes	functions
T8706	5725-5727	IN	denotes	in
T8707	5728-5731	DT	denotes	the
T8708	5732-5736	NN	denotes	limb
T8709	5737-5740	CC	denotes	and
T8710	5741-5744	DT	denotes	the
T8711	5745-5750	NN	denotes	trunk
T8712	5751-5757	IN	denotes	during
T8713	5758-5763	JJ	denotes	early
T8714	5775-5784	NN	denotes	evolution
T8715	5764-5774	NN	denotes	vertebrate
T8716	5784-5785	.	denotes	.
T8717	5785-5985	sentence	denotes	Expression of Tbx18 and Tbx22 has not been reported in embryonic flank mesenchyme, which suggests that Tbx15 is the only family member involved in establishing the dorsoventral identity of the trunk.
T8718	5786-5796	NN	denotes	Expression
T8719	5829-5837	VBN	denotes	reported
T8720	5797-5799	IN	denotes	of
T8721	5800-5805	NN	denotes	Tbx18
T8722	5806-5809	CC	denotes	and
T8723	5810-5815	NN	denotes	Tbx22
T8724	5816-5819	VBZ	denotes	has
T8725	5820-5823	RB	denotes	not
T8726	5824-5828	VBN	denotes	been
T8727	5838-5840	IN	denotes	in
T8728	5841-5850	JJ	denotes	embryonic
T8729	5857-5867	NN	denotes	mesenchyme
T8730	5851-5856	NN	denotes	flank
T8731	5867-5869	,	denotes	,
T8732	5869-5874	WDT	denotes	which
T8733	5875-5883	VBZ	denotes	suggests
T8734	5884-5888	IN	denotes	that
T8735	5895-5897	VBZ	denotes	is
T8736	5889-5894	NN	denotes	Tbx15
T8737	5898-5901	DT	denotes	the
T8738	5914-5920	NN	denotes	member
T8739	5902-5906	JJ	denotes	only
T8740	5907-5913	NN	denotes	family
T8741	5921-5929	VBN	denotes	involved
T8742	5930-5932	IN	denotes	in
T8743	5933-5945	VBG	denotes	establishing
T8744	5946-5949	DT	denotes	the
T8745	5963-5971	NN	denotes	identity
T8746	5950-5962	JJ	denotes	dorsoventral
T8747	5972-5974	IN	denotes	of
T8748	5975-5978	DT	denotes	the
T8749	5979-5984	NN	denotes	trunk
T8750	5984-5985	.	denotes	.
T8751	5985-6187	sentence	denotes	However, it would not be surprising to find some degree of functional redundancy in animals mutated for two or three of the subfamily members in other body regions, particularly the limbs and the head.
T8752	5986-5993	RB	denotes	However
T8753	6008-6010	VB	denotes	be
T8754	5993-5995	,	denotes	,
T8755	5995-5997	PRP	denotes	it
T8756	5998-6003	MD	denotes	would
T8757	6004-6007	RB	denotes	not
T8758	6011-6021	JJ	denotes	surprising
T8759	6022-6024	TO	denotes	to
T8760	6025-6029	VB	denotes	find
T8761	6030-6034	DT	denotes	some
T8762	6035-6041	NN	denotes	degree
T8763	6042-6044	IN	denotes	of
T8764	6045-6055	JJ	denotes	functional
T8765	6056-6066	NN	denotes	redundancy
T8766	6067-6069	IN	denotes	in
T8767	6070-6077	NNS	denotes	animals
T8768	6078-6085	VBN	denotes	mutated
T8769	6086-6089	IN	denotes	for
T8770	6090-6093	CD	denotes	two
T8771	6094-6096	CC	denotes	or
T8772	6097-6102	CD	denotes	three
T8773	6103-6105	IN	denotes	of
T8774	6106-6109	DT	denotes	the
T8775	6120-6127	NNS	denotes	members
T8776	6110-6119	NN	denotes	subfamily
T8777	6128-6130	IN	denotes	in
T8778	6131-6136	JJ	denotes	other
T8779	6142-6149	NNS	denotes	regions
T8780	6137-6141	NN	denotes	body
T8781	6149-6151	,	denotes	,
T8782	6151-6163	RB	denotes	particularly
T8783	6168-6173	NNS	denotes	limbs
T8784	6164-6167	DT	denotes	the
T8785	6174-6177	CC	denotes	and
T8786	6178-6181	DT	denotes	the
T8787	6182-6186	NN	denotes	head
T8788	6186-6187	.	denotes	.
T8789	6187-6309	sentence	denotes	For example, mutations in Tbx22 cause the human syndrome X-linked cleft palate and ankyloglossia (Braybrook et al. 2001).
T8790	6188-6191	IN	denotes	For
T8791	6220-6225	VBP	denotes	cause
T8792	6192-6199	NN	denotes	example
T8793	6199-6201	,	denotes	,
T8794	6201-6210	NNS	denotes	mutations
T8795	6211-6213	IN	denotes	in
T8796	6214-6219	NN	denotes	Tbx22
T8797	6226-6229	DT	denotes	the
T8798	6236-6244	NN	denotes	syndrome
T8799	6230-6235	JJ	denotes	human
T8800	6245-6246	NN	denotes	X
T8801	6247-6253	VBN	denotes	linked
T8802	6246-6247	HYPH	denotes	-
T8803	6260-6266	NN	denotes	palate
T8804	6254-6259	JJ	denotes	cleft
T8805	6267-6270	CC	denotes	and
T8806	6271-6284	NN	denotes	ankyloglossia
T8807	6285-6286	-LRB-	denotes	(
T8808	6286-6295	NNP	denotes	Braybrook
T8809	6296-6298	FW	denotes	et
T8810	6299-6302	FW	denotes	al.
T8811	6303-6307	CD	denotes	2001
T8812	6307-6308	-RRB-	denotes	)
T8813	6308-6309	.	denotes	.
T8814	6309-6559	sentence	denotes	Despite high levels of Tbx22 expression in periocular embryonic mesenchyme (Braybrook et al. 2002; Bush et al. 2002; Herr et al. 2003), the condition does not affect the eye, perhaps because residual activity is provided by Tbx15 in the same region.
T8815	6310-6317	IN	denotes	Despite
T8816	6469-6475	VB	denotes	affect
T8817	6318-6322	JJ	denotes	high
T8818	6323-6329	NNS	denotes	levels
T8819	6330-6332	IN	denotes	of
T8820	6333-6338	NN	denotes	Tbx22
T8821	6339-6349	NN	denotes	expression
T8822	6350-6352	IN	denotes	in
T8823	6353-6363	JJ	denotes	periocular
T8824	6374-6384	NN	denotes	mesenchyme
T8825	6364-6373	JJ	denotes	embryonic
T8826	6385-6386	-LRB-	denotes	(
T8827	6386-6395	NNP	denotes	Braybrook
T8828	6396-6398	FW	denotes	et
T8829	6399-6402	FW	denotes	al.
T8830	6403-6407	CD	denotes	2002
T8831	6407-6408	:	denotes	;
T8832	6409-6413	NNP	denotes	Bush
T8833	6414-6416	FW	denotes	et
T8834	6417-6420	FW	denotes	al.
T8835	6421-6425	CD	denotes	2002
T8836	6425-6426	:	denotes	;
T8837	6427-6431	NNP	denotes	Herr
T8838	6432-6434	FW	denotes	et
T8839	6435-6438	FW	denotes	al.
T8840	6439-6443	CD	denotes	2003
T8841	6443-6444	-RRB-	denotes	)
T8842	6444-6446	,	denotes	,
T8843	6446-6449	DT	denotes	the
T8844	6450-6459	NN	denotes	condition
T8845	6460-6464	VBZ	denotes	does
T8846	6465-6468	RB	denotes	not
T8847	6476-6479	DT	denotes	the
T8848	6480-6483	NN	denotes	eye
T8849	6483-6485	,	denotes	,
T8850	6485-6492	RB	denotes	perhaps
T8851	6522-6530	VBN	denotes	provided
T8852	6493-6500	IN	denotes	because
T8853	6501-6509	JJ	denotes	residual
T8854	6510-6518	NN	denotes	activity
T8855	6519-6521	VBZ	denotes	is
T8856	6531-6533	IN	denotes	by
T8857	6534-6539	NN	denotes	Tbx15
T8858	6540-6542	IN	denotes	in
T8859	6543-6546	DT	denotes	the
T8860	6552-6558	NN	denotes	region
T8861	6547-6551	JJ	denotes	same
T8862	6558-6559	.	denotes	.
T8863	6559-6861	sentence	denotes	In an initial description of the expression and map location of mouse Tbx15, Agulnik et al. (1998) suggested human Tbx15 that lies on Chromosome 1p11.1 as a candidate for acromegaloid facial appearance (AFA) syndrome, for which there is a weak positive LOD score to Chromosome 1p (Hughes et al. 1985).
T8864	6560-6562	IN	denotes	In
T8865	6659-6668	VBD	denotes	suggested
T8866	6563-6565	DT	denotes	an
T8867	6574-6585	NN	denotes	description
T8868	6566-6573	JJ	denotes	initial
T8869	6586-6588	IN	denotes	of
T8870	6589-6592	DT	denotes	the
T8871	6593-6603	NN	denotes	expression
T8872	6604-6607	CC	denotes	and
T8873	6608-6611	NN	denotes	map
T8874	6612-6620	NN	denotes	location
T8875	6621-6623	IN	denotes	of
T8876	6624-6629	NN	denotes	mouse
T8877	6630-6635	NN	denotes	Tbx15
T8878	6635-6637	,	denotes	,
T8879	6637-6644	NNP	denotes	Agulnik
T8880	6645-6647	FW	denotes	et
T8881	6648-6651	FW	denotes	al.
T8882	6652-6653	-LRB-	denotes	(
T8883	6653-6657	CD	denotes	1998
T8884	6657-6658	-RRB-	denotes	)
T8885	6669-6674	JJ	denotes	human
T8886	6675-6680	NN	denotes	Tbx15
T8887	6681-6685	WDT	denotes	that
T8888	6686-6690	VBZ	denotes	lies
T8889	6691-6693	IN	denotes	on
T8890	6694-6704	NN	denotes	Chromosome
T8891	6705-6711	NN	denotes	1p11.1
T8892	6712-6714	IN	denotes	as
T8893	6715-6716	DT	denotes	a
T8894	6717-6726	NN	denotes	candidate
T8895	6727-6730	IN	denotes	for
T8896	6731-6743	JJ	denotes	acromegaloid
T8897	6751-6761	NN	denotes	appearance
T8898	6744-6750	JJ	denotes	facial
T8899	6768-6776	NN	denotes	syndrome
T8900	6762-6763	-LRB-	denotes	(
T8901	6763-6766	NN	denotes	AFA
T8902	6766-6767	-RRB-	denotes	)
T8903	6776-6778	,	denotes	,
T8904	6778-6781	IN	denotes	for
T8905	6794-6796	VBZ	denotes	is
T8906	6782-6787	WDT	denotes	which
T8907	6788-6793	EX	denotes	there
T8908	6797-6798	DT	denotes	a
T8909	6817-6822	NN	denotes	score
T8910	6799-6803	JJ	denotes	weak
T8911	6804-6812	JJ	denotes	positive
T8912	6813-6816	NN	denotes	LOD
T8913	6823-6825	IN	denotes	to
T8914	6826-6836	NN	denotes	Chromosome
T8915	6837-6839	NN	denotes	1p
T8916	6840-6841	-LRB-	denotes	(
T8917	6841-6847	NNP	denotes	Hughes
T8918	6848-6850	FW	denotes	et
T8919	6851-6854	FW	denotes	al.
T8920	6855-6859	CD	denotes	1985
T8921	6859-6860	-RRB-	denotes	)
T8922	6860-6861	.	denotes	.
T8923	6861-7235	sentence	denotes	Originally described as a rare autosomal-dominant syndrome with progressive facial coarsening, overgrowth of the intraoral mucosa, and large, doughy hands, more recent case reports describe macrosomia, macrocephaly, or both and generalized hypertrichosis with progressive coarsening (Dallapiccola et al. 1992; Irvine et al. 1996; da Silva et al. 1998; Zelante et al. 2000).
T8924	6862-6872	RB	denotes	Originally
T8925	6873-6882	VBN	denotes	described
T8926	7043-7051	VBP	denotes	describe
T8927	6883-6885	IN	denotes	as
T8928	6886-6887	DT	denotes	a
T8929	6912-6920	NN	denotes	syndrome
T8930	6888-6892	JJ	denotes	rare
T8931	6893-6902	JJ	denotes	autosomal
T8932	6903-6911	JJ	denotes	dominant
T8933	6902-6903	HYPH	denotes	-
T8934	6921-6925	IN	denotes	with
T8935	6926-6937	JJ	denotes	progressive
T8936	6945-6955	NN	denotes	coarsening
T8937	6938-6944	JJ	denotes	facial
T8938	6955-6957	,	denotes	,
T8939	6957-6967	NN	denotes	overgrowth
T8940	6968-6970	IN	denotes	of
T8941	6971-6974	DT	denotes	the
T8942	6985-6991	NN	denotes	mucosa
T8943	6975-6984	JJ	denotes	intraoral
T8944	6991-6993	,	denotes	,
T8945	6993-6996	CC	denotes	and
T8946	6997-7002	JJ	denotes	large
T8947	7011-7016	NNS	denotes	hands
T8948	7002-7004	,	denotes	,
T8949	7004-7010	JJ	denotes	doughy
T8950	7016-7018	,	denotes	,
T8951	7018-7022	RBR	denotes	more
T8952	7023-7029	JJ	denotes	recent
T8953	7035-7042	NNS	denotes	reports
T8954	7030-7034	NN	denotes	case
T8955	7052-7062	NN	denotes	macrosomia
T8956	7062-7064	,	denotes	,
T8957	7064-7076	NN	denotes	macrocephaly
T8958	7076-7078	,	denotes	,
T8959	7078-7080	CC	denotes	or
T8960	7081-7085	DT	denotes	both
T8961	7086-7089	CC	denotes	and
T8962	7090-7101	VBN	denotes	generalized
T8963	7102-7116	NN	denotes	hypertrichosis
T8964	7117-7121	IN	denotes	with
T8965	7122-7133	JJ	denotes	progressive
T8966	7134-7144	NN	denotes	coarsening
T8967	7145-7146	-LRB-	denotes	(
T8968	7146-7158	NNP	denotes	Dallapiccola
T8969	7159-7161	FW	denotes	et
T8970	7162-7165	FW	denotes	al.
T8971	7166-7170	CD	denotes	1992
T8972	7170-7171	:	denotes	;
T8973	7172-7178	NNP	denotes	Irvine
T8974	7179-7181	FW	denotes	et
T8975	7182-7185	FW	denotes	al.
T8976	7186-7190	CD	denotes	1996
T8977	7190-7191	:	denotes	;
T8978	7192-7194	NNP	denotes	da
T8979	7195-7200	NNP	denotes	Silva
T8980	7201-7203	FW	denotes	et
T8981	7204-7207	FW	denotes	al.
T8982	7208-7212	CD	denotes	1998
T8983	7212-7213	:	denotes	;
T8984	7214-7221	NNP	denotes	Zelante
T8985	7222-7224	FW	denotes	et
T8986	7225-7228	FW	denotes	al.
T8987	7229-7233	CD	denotes	2000
T8988	7233-7234	-RRB-	denotes	)
T8989	7234-7235	.	denotes	.
T8990	7235-7545	sentence	denotes	The deH phenotype exhibits little overlap with these features; instead, we suggest a more likely candidate for mutations of human TBX15 would be frontofacionasal syndrome, an unmapped autosomal recessive condition characterized by brachycephaly, blepharophimosis, and midface hypoplasia (Reardon et al. 1994).
T8991	7236-7239	DT	denotes	The
T8992	7244-7253	NN	denotes	phenotype
T8993	7240-7243	NN	denotes	deH
T8994	7254-7262	VBZ	denotes	exhibits
T8995	7311-7318	VBP	denotes	suggest
T8996	7263-7269	JJ	denotes	little
T8997	7270-7277	NN	denotes	overlap
T8998	7278-7282	IN	denotes	with
T8999	7283-7288	DT	denotes	these
T9000	7289-7297	NNS	denotes	features
T9001	7297-7298	:	denotes	;
T9002	7299-7306	RB	denotes	instead
T9003	7306-7308	,	denotes	,
T9004	7308-7310	PRP	denotes	we
T9005	7319-7320	DT	denotes	a
T9006	7333-7342	NN	denotes	candidate
T9007	7321-7325	RBR	denotes	more
T9008	7326-7332	JJ	denotes	likely
T9009	7378-7380	VB	denotes	be
T9010	7343-7346	IN	denotes	for
T9011	7347-7356	NNS	denotes	mutations
T9012	7357-7359	IN	denotes	of
T9013	7360-7365	JJ	denotes	human
T9014	7366-7371	NN	denotes	TBX15
T9015	7372-7377	MD	denotes	would
T9016	7381-7397	JJ	denotes	frontofacionasal
T9017	7398-7406	NN	denotes	syndrome
T9018	7406-7408	,	denotes	,
T9019	7408-7410	DT	denotes	an
T9020	7440-7449	NN	denotes	condition
T9021	7411-7419	JJ	denotes	unmapped
T9022	7420-7429	JJ	denotes	autosomal
T9023	7430-7439	JJ	denotes	recessive
T9024	7450-7463	VBN	denotes	characterized
T9025	7464-7466	IN	denotes	by
T9026	7467-7480	RB	denotes	brachycephaly
T9027	7480-7482	,	denotes	,
T9028	7482-7498	NN	denotes	blepharophimosis
T9029	7498-7500	,	denotes	,
T9030	7500-7503	CC	denotes	and
T9031	7504-7511	JJ	denotes	midface
T9032	7512-7522	NN	denotes	hypoplasia
T9033	7523-7524	-LRB-	denotes	(
T9034	7524-7531	NNP	denotes	Reardon
T9035	7532-7534	FW	denotes	et
T9036	7535-7538	FW	denotes	al.
T9037	7539-7543	CD	denotes	1994
T9038	7543-7544	-RRB-	denotes	)
T9039	7544-7545	.	denotes	.
T9040	7545-7798	sentence	denotes	Two of us (S. Kuijper and F. Meijlink) became interested in the deH mutation because of its effects on skeletal development (Curry 1959) and the possibility that the aristaless-related gene Alx3 might be allelic with droopy ear (ten Berge et al. 1998).
T9041	7546-7549	CD	denotes	Two
T9042	7585-7591	VBD	denotes	became
T9043	7550-7552	IN	denotes	of
T9044	7553-7555	PRP	denotes	us
T9045	7556-7557	-LRB-	denotes	(
T9046	7557-7559	NNP	denotes	S.
T9047	7560-7567	NNP	denotes	Kuijper
T9048	7568-7571	CC	denotes	and
T9049	7572-7574	NNP	denotes	F.
T9050	7575-7583	NNP	denotes	Meijlink
T9051	7583-7584	-RRB-	denotes	)
T9052	7592-7602	JJ	denotes	interested
T9053	7603-7605	IN	denotes	in
T9054	7606-7609	DT	denotes	the
T9055	7614-7622	NN	denotes	mutation
T9056	7610-7613	NN	denotes	deH
T9057	7623-7630	IN	denotes	because
T9058	7631-7633	IN	denotes	of
T9059	7634-7637	PRP$	denotes	its
T9060	7638-7645	NNS	denotes	effects
T9061	7646-7648	IN	denotes	on
T9062	7649-7657	JJ	denotes	skeletal
T9063	7658-7669	NN	denotes	development
T9064	7670-7671	-LRB-	denotes	(
T9065	7671-7676	NNP	denotes	Curry
T9066	7677-7681	CD	denotes	1959
T9067	7681-7682	-RRB-	denotes	)
T9068	7683-7686	CC	denotes	and
T9069	7687-7690	DT	denotes	the
T9070	7691-7702	NN	denotes	possibility
T9071	7703-7707	IN	denotes	that
T9072	7747-7749	VB	denotes	be
T9073	7708-7711	DT	denotes	the
T9074	7731-7735	NN	denotes	gene
T9075	7712-7722	NN	denotes	aristaless
T9076	7723-7730	VBN	denotes	related
T9077	7722-7723	HYPH	denotes	-
T9078	7736-7740	NN	denotes	Alx3
T9079	7741-7746	MD	denotes	might
T9080	7750-7757	JJ	denotes	allelic
T9081	7758-7762	IN	denotes	with
T9082	7763-7769	JJ	denotes	droopy
T9083	7770-7773	NN	denotes	ear
T9084	7774-7775	-LRB-	denotes	(
T9085	7775-7778	NNP	denotes	ten
T9086	7779-7784	NNP	denotes	Berge
T9087	7785-7787	FW	denotes	et
T9088	7788-7791	FW	denotes	al.
T9089	7792-7796	CD	denotes	1998
T9090	7796-7797	-RRB-	denotes	)
T9091	7797-7798	.	denotes	.
T9092	7798-8045	sentence	denotes	In spite of similarities between skeletal phenotypes of deH and Alx3 or Alx4 mutants, subsequent experiments (unpublished data) excluded allelism of Alx3 and deH, and a full description of the Tbx15 skeletal phenotype will be published elsewhere.
T9093	7799-7801	IN	denotes	In
T9094	7927-7935	VBD	denotes	excluded
T9095	7802-7807	NN	denotes	spite
T9096	7808-7810	IN	denotes	of
T9097	7811-7823	NNS	denotes	similarities
T9098	7824-7831	IN	denotes	between
T9099	7832-7840	JJ	denotes	skeletal
T9100	7841-7851	NNS	denotes	phenotypes
T9101	7852-7854	IN	denotes	of
T9102	7855-7858	NN	denotes	deH
T9103	7876-7883	NNS	denotes	mutants
T9104	7859-7862	CC	denotes	and
T9105	7863-7867	NN	denotes	Alx3
T9106	7868-7870	CC	denotes	or
T9107	7871-7875	NN	denotes	Alx4
T9108	7883-7885	,	denotes	,
T9109	7885-7895	JJ	denotes	subsequent
T9110	7896-7907	NNS	denotes	experiments
T9111	7908-7909	-LRB-	denotes	(
T9112	7921-7925	NNS	denotes	data
T9113	7909-7920	JJ	denotes	unpublished
T9114	7925-7926	-RRB-	denotes	)
T9115	7936-7944	NN	denotes	allelism
T9116	7945-7947	IN	denotes	of
T9117	7948-7952	NN	denotes	Alx3
T9118	7953-7956	CC	denotes	and
T9119	7957-7960	NN	denotes	deH
T9120	7960-7962	,	denotes	,
T9121	7962-7965	CC	denotes	and
T9122	7966-7967	DT	denotes	a
T9123	7973-7984	NN	denotes	description
T9124	7968-7972	JJ	denotes	full
T9125	8025-8034	VBN	denotes	published
T9126	7985-7987	IN	denotes	of
T9127	7988-7991	DT	denotes	the
T9128	8007-8016	NN	denotes	phenotype
T9129	7992-7997	NN	denotes	Tbx15
T9130	7998-8006	JJ	denotes	skeletal
T9131	8017-8021	MD	denotes	will
T9132	8022-8024	VB	denotes	be
T9133	8035-8044	RB	denotes	elsewhere
T9134	8044-8045	.	denotes	.
T9366	8047-8060	JJ	denotes	Developmental
T9367	8061-8070	NN	denotes	Mechanism
T9368	8071-8073	IN	denotes	of
T9369	8074-8079	NN	denotes	Tbx15
T9370	8080-8090	NN	denotes	Expression
T9371	8091-8094	CC	denotes	and
T9372	8095-8101	NN	denotes	Action
T9373	8102-8104	IN	denotes	in
T9374	8105-8108	DT	denotes	the
T9375	8109-8113	NN	denotes	Skin
T9376	8113-8231	sentence	denotes	Our attention to the role of Tbx15 in pigment patterning was motivated by the effects of Agouti in postnatal animals.
T9377	8114-8117	PRP$	denotes	Our
T9378	8118-8127	NN	denotes	attention
T9379	8175-8184	VBN	denotes	motivated
T9380	8128-8130	IN	denotes	to
T9381	8131-8134	DT	denotes	the
T9382	8135-8139	NN	denotes	role
T9383	8140-8142	IN	denotes	of
T9384	8143-8148	NN	denotes	Tbx15
T9385	8149-8151	IN	denotes	in
T9386	8152-8159	NN	denotes	pigment
T9387	8160-8170	NN	denotes	patterning
T9388	8171-8174	VBD	denotes	was
T9389	8185-8187	IN	denotes	by
T9390	8188-8191	DT	denotes	the
T9391	8192-8199	NNS	denotes	effects
T9392	8200-8202	IN	denotes	of
T9393	8203-8209	NN	denotes	Agouti
T9394	8210-8212	IN	denotes	in
T9395	8213-8222	JJ	denotes	postnatal
T9396	8223-8230	NNS	denotes	animals
T9397	8230-8231	.	denotes	.
T9398	8231-8346	sentence	denotes	However, Agouti is also expressed in the embryo, where it provides a convenient marker of ventral dermis identity.
T9399	8232-8239	RB	denotes	However
T9400	8256-8265	VBN	denotes	expressed
T9401	8239-8241	,	denotes	,
T9402	8241-8247	NN	denotes	Agouti
T9403	8248-8250	VBZ	denotes	is
T9404	8251-8255	RB	denotes	also
T9405	8266-8268	IN	denotes	in
T9406	8269-8272	DT	denotes	the
T9407	8273-8279	NN	denotes	embryo
T9408	8279-8281	,	denotes	,
T9409	8281-8286	WRB	denotes	where
T9410	8290-8298	VBZ	denotes	provides
T9411	8287-8289	PRP	denotes	it
T9412	8299-8300	DT	denotes	a
T9413	8312-8318	NN	denotes	marker
T9414	8301-8311	JJ	denotes	convenient
T9415	8319-8321	IN	denotes	of
T9416	8322-8329	JJ	denotes	ventral
T9417	8337-8345	NN	denotes	identity
T9418	8330-8336	NN	denotes	dermis
T9419	8345-8346	.	denotes	.
T9420	8346-8526	sentence	denotes	Because an expanded domain of embryonic Agouti expression in deH/deH animals is detectable by E14.5, the effects of Tbx15 on dorsoventral patterning must occur prior to this time.
T9421	8347-8354	IN	denotes	Because
T9422	8424-8426	VBZ	denotes	is
T9423	8355-8357	DT	denotes	an
T9424	8367-8373	NN	denotes	domain
T9425	8358-8366	VBN	denotes	expanded
T9426	8374-8376	IN	denotes	of
T9427	8377-8386	JJ	denotes	embryonic
T9428	8394-8404	NN	denotes	expression
T9429	8387-8393	NN	denotes	Agouti
T9430	8405-8407	IN	denotes	in
T9431	8408-8411	NN	denotes	deH
T9432	8412-8415	NN	denotes	deH
T9433	8411-8412	HYPH	denotes	/
T9434	8416-8423	NNS	denotes	animals
T9435	8501-8506	VB	denotes	occur
T9436	8427-8437	JJ	denotes	detectable
T9437	8438-8440	IN	denotes	by
T9438	8441-8446	NN	denotes	E14.5
T9439	8446-8448	,	denotes	,
T9440	8448-8451	DT	denotes	the
T9441	8452-8459	NNS	denotes	effects
T9442	8460-8462	IN	denotes	of
T9443	8463-8468	NN	denotes	Tbx15
T9444	8469-8471	IN	denotes	on
T9445	8472-8484	JJ	denotes	dorsoventral
T9446	8485-8495	NN	denotes	patterning
T9447	8496-8500	MD	denotes	must
T9448	8507-8512	RB	denotes	prior
T9449	8513-8515	IN	denotes	to
T9450	8516-8520	DT	denotes	this
T9451	8521-8525	NN	denotes	time
T9452	8525-8526	.	denotes	.
T9453	8526-8910	sentence	denotes	Among other T-box genes whose developmental actions are at least partially understood, two general themes have emerged, one focused on the ability to specify alternative fates for an undifferentiated group of precursor cells and another focused on the ability to support proliferative expansion of a cell population whose fate is already determined (reviewed in Tada and Smith 2001).
T9454	8527-8532	IN	denotes	Among
T9455	8638-8645	VBN	denotes	emerged
T9456	8533-8538	JJ	denotes	other
T9457	8545-8550	NNS	denotes	genes
T9458	8539-8540	NN	denotes	T
T9459	8541-8544	NN	denotes	box
T9460	8540-8541	HYPH	denotes	-
T9461	8551-8556	WP$	denotes	whose
T9462	8571-8578	NNS	denotes	actions
T9463	8557-8570	JJ	denotes	developmental
T9464	8602-8612	VBN	denotes	understood
T9465	8579-8582	VBP	denotes	are
T9466	8583-8585	RB	denotes	at
T9467	8586-8591	RBS	denotes	least
T9468	8592-8601	RB	denotes	partially
T9469	8612-8614	,	denotes	,
T9470	8614-8617	CD	denotes	two
T9471	8626-8632	NNS	denotes	themes
T9472	8618-8625	JJ	denotes	general
T9473	8633-8637	VBP	denotes	have
T9474	8645-8647	,	denotes	,
T9475	8647-8650	CD	denotes	one
T9476	8651-8658	VBD	denotes	focused
T9477	8659-8661	IN	denotes	on
T9478	8662-8665	DT	denotes	the
T9479	8666-8673	NN	denotes	ability
T9480	8674-8676	TO	denotes	to
T9481	8677-8684	VB	denotes	specify
T9482	8685-8696	JJ	denotes	alternative
T9483	8697-8702	NNS	denotes	fates
T9484	8703-8706	IN	denotes	for
T9485	8707-8709	DT	denotes	an
T9486	8727-8732	NN	denotes	group
T9487	8710-8726	JJ	denotes	undifferentiated
T9488	8733-8735	IN	denotes	of
T9489	8736-8745	NN	denotes	precursor
T9490	8746-8751	NNS	denotes	cells
T9491	8752-8755	CC	denotes	and
T9492	8756-8763	DT	denotes	another
T9493	8764-8771	VBD	denotes	focused
T9494	8772-8774	IN	denotes	on
T9495	8775-8778	DT	denotes	the
T9496	8779-8786	NN	denotes	ability
T9497	8787-8789	TO	denotes	to
T9498	8790-8797	VB	denotes	support
T9499	8798-8811	JJ	denotes	proliferative
T9500	8812-8821	NN	denotes	expansion
T9501	8822-8824	IN	denotes	of
T9502	8825-8826	DT	denotes	a
T9503	8832-8842	NN	denotes	population
T9504	8827-8831	NN	denotes	cell
T9505	8843-8848	WP$	denotes	whose
T9506	8849-8853	NN	denotes	fate
T9507	8865-8875	VBN	denotes	determined
T9508	8854-8856	VBZ	denotes	is
T9509	8857-8864	RB	denotes	already
T9510	8876-8877	-LRB-	denotes	(
T9511	8877-8885	VBN	denotes	reviewed
T9512	8886-8888	IN	denotes	in
T9513	8889-8893	NNP	denotes	Tada
T9514	8894-8897	CC	denotes	and
T9515	8898-8903	NNP	denotes	Smith
T9516	8904-8908	CD	denotes	2001
T9517	8908-8909	-RRB-	denotes	)
T9518	8909-8910	.	denotes	.
T9519	8910-9003	sentence	denotes	Either mechanism may apply to the apparent dorsal-to-ventral transformation in deH/deH mice.
T9520	8911-8917	DT	denotes	Either
T9521	8918-8927	NN	denotes	mechanism
T9522	8932-8937	VB	denotes	apply
T9523	8928-8931	MD	denotes	may
T9524	8938-8940	IN	denotes	to
T9525	8941-8944	DT	denotes	the
T9526	8972-8986	NN	denotes	transformation
T9527	8945-8953	JJ	denotes	apparent
T9528	8954-8960	JJ	denotes	dorsal
T9529	8960-8961	HYPH	denotes	-
T9530	8961-8963	IN	denotes	to
T9531	8963-8964	HYPH	denotes	-
T9532	8964-8971	JJ	denotes	ventral
T9533	8987-8989	IN	denotes	in
T9534	8990-8993	NN	denotes	deH
T9535	8994-8997	NN	denotes	deH
T9536	8993-8994	HYPH	denotes	/
T9537	8998-9002	NNS	denotes	mice
T9538	9002-9003	.	denotes	.
T9539	9003-9377	sentence	denotes	For example, while the expanded domain of Agouti expression in postnatal deH/deH animals can be traced to events that occur between E11.5 and E13.5, the underlying cause may be that embryonic cells in dorsolateral mesenchyme acquire a ventral rather than dorsal identity or that those cells fail to proliferate normally, followed by compensatory expansion of ventral cells.
T9540	9004-9007	IN	denotes	For
T9541	9178-9180	VB	denotes	be
T9542	9008-9015	NN	denotes	example
T9543	9015-9017	,	denotes	,
T9544	9017-9022	IN	denotes	while
T9545	9100-9106	VBN	denotes	traced
T9546	9023-9026	DT	denotes	the
T9547	9036-9042	NN	denotes	domain
T9548	9027-9035	VBN	denotes	expanded
T9549	9043-9045	IN	denotes	of
T9550	9046-9052	NN	denotes	Agouti
T9551	9053-9063	NN	denotes	expression
T9552	9064-9066	IN	denotes	in
T9553	9067-9076	JJ	denotes	postnatal
T9554	9085-9092	NNS	denotes	animals
T9555	9077-9080	NN	denotes	deH
T9556	9081-9084	NN	denotes	deH
T9557	9080-9081	HYPH	denotes	/
T9558	9093-9096	MD	denotes	can
T9559	9097-9099	VB	denotes	be
T9560	9107-9109	IN	denotes	to
T9561	9110-9116	NNS	denotes	events
T9562	9117-9121	WDT	denotes	that
T9563	9122-9127	VBP	denotes	occur
T9564	9128-9135	IN	denotes	between
T9565	9136-9141	NN	denotes	E11.5
T9566	9142-9145	CC	denotes	and
T9567	9146-9151	NN	denotes	E13.5
T9568	9151-9153	,	denotes	,
T9569	9153-9156	DT	denotes	the
T9570	9168-9173	NN	denotes	cause
T9571	9157-9167	JJ	denotes	underlying
T9572	9174-9177	MD	denotes	may
T9573	9181-9185	IN	denotes	that
T9574	9229-9236	VBP	denotes	acquire
T9575	9186-9195	JJ	denotes	embryonic
T9576	9196-9201	NNS	denotes	cells
T9577	9202-9204	IN	denotes	in
T9578	9205-9217	JJ	denotes	dorsolateral
T9579	9218-9228	NN	denotes	mesenchyme
T9580	9237-9238	DT	denotes	a
T9581	9266-9274	NN	denotes	identity
T9582	9239-9246	JJ	denotes	ventral
T9583	9247-9253	IN	denotes	rather
T9584	9254-9258	IN	denotes	than
T9585	9259-9265	JJ	denotes	dorsal
T9586	9275-9277	CC	denotes	or
T9587	9278-9282	IN	denotes	that
T9588	9295-9299	VBP	denotes	fail
T9589	9283-9288	DT	denotes	those
T9590	9289-9294	NNS	denotes	cells
T9591	9300-9302	TO	denotes	to
T9592	9303-9314	VB	denotes	proliferate
T9593	9315-9323	RB	denotes	normally
T9594	9323-9325	,	denotes	,
T9595	9325-9333	VBN	denotes	followed
T9596	9334-9336	IN	denotes	by
T9597	9337-9349	JJ	denotes	compensatory
T9598	9350-9359	NN	denotes	expansion
T9599	9360-9362	IN	denotes	of
T9600	9363-9370	JJ	denotes	ventral
T9601	9371-9376	NNS	denotes	cells
T9602	9376-9377	.	denotes	.
T9603	9377-9700	sentence	denotes	Cell lineage studies should provide a definitive answer, but we favor the latter hypothesis, because measurements of dorsoventral regions according to hair color in deH/deH mice revealed a small increase of the cream-colored ventral region in addition to the approximate doubling of the yellow flank region (see Figure 2).
T9604	9378-9382	NN	denotes	Cell
T9605	9383-9390	NN	denotes	lineage
T9606	9391-9398	NNS	denotes	studies
T9607	9406-9413	VB	denotes	provide
T9608	9399-9405	MD	denotes	should
T9609	9414-9415	DT	denotes	a
T9610	9427-9433	NN	denotes	answer
T9611	9416-9426	JJ	denotes	definitive
T9612	9433-9435	,	denotes	,
T9613	9435-9438	CC	denotes	but
T9614	9439-9441	PRP	denotes	we
T9615	9442-9447	VBP	denotes	favor
T9616	9448-9451	DT	denotes	the
T9617	9459-9469	NN	denotes	hypothesis
T9618	9452-9458	JJ	denotes	latter
T9619	9469-9471	,	denotes	,
T9620	9471-9478	IN	denotes	because
T9621	9556-9564	VBD	denotes	revealed
T9622	9479-9491	NNS	denotes	measurements
T9623	9492-9494	IN	denotes	of
T9624	9495-9507	JJ	denotes	dorsoventral
T9625	9508-9515	NNS	denotes	regions
T9626	9516-9525	VBG	denotes	according
T9627	9526-9528	IN	denotes	to
T9628	9529-9533	NN	denotes	hair
T9629	9534-9539	NN	denotes	color
T9630	9540-9542	IN	denotes	in
T9631	9543-9546	NN	denotes	deH
T9632	9547-9550	NN	denotes	deH
T9633	9546-9547	HYPH	denotes	/
T9634	9551-9555	NNS	denotes	mice
T9635	9565-9566	DT	denotes	a
T9636	9573-9581	NN	denotes	increase
T9637	9567-9572	JJ	denotes	small
T9638	9582-9584	IN	denotes	of
T9639	9585-9588	DT	denotes	the
T9640	9611-9617	NN	denotes	region
T9641	9589-9594	JJ	denotes	cream
T9642	9595-9602	JJ	denotes	colored
T9643	9594-9595	HYPH	denotes	-
T9644	9603-9610	JJ	denotes	ventral
T9645	9618-9620	IN	denotes	in
T9646	9621-9629	NN	denotes	addition
T9647	9630-9632	IN	denotes	to
T9648	9633-9636	DT	denotes	the
T9649	9649-9657	NN	denotes	doubling
T9650	9637-9648	JJ	denotes	approximate
T9651	9658-9660	IN	denotes	of
T9652	9661-9664	DT	denotes	the
T9653	9678-9684	NN	denotes	region
T9654	9665-9671	JJ	denotes	yellow
T9655	9672-9677	NN	denotes	flank
T9656	9685-9686	-LRB-	denotes	(
T9657	9686-9689	VB	denotes	see
T9658	9690-9696	NN	denotes	Figure
T9659	9697-9698	CD	denotes	2
T9660	9698-9699	-RRB-	denotes	)
T9661	9699-9700	.	denotes	.
T9662	9700-9879	sentence	denotes	In embryonic mesenchyme, expression of Tbx15 and Agouti are complementary, and it is possible that Tbx15 acts directly to inhibit Agouti transcription in dorsolateral mesenchyme.
T9663	9701-9703	IN	denotes	In
T9664	9757-9760	VBP	denotes	are
T9665	9704-9713	JJ	denotes	embryonic
T9666	9714-9724	NN	denotes	mesenchyme
T9667	9724-9726	,	denotes	,
T9668	9726-9736	NN	denotes	expression
T9669	9737-9739	IN	denotes	of
T9670	9740-9745	NN	denotes	Tbx15
T9671	9746-9749	CC	denotes	and
T9672	9750-9756	NN	denotes	Agouti
T9673	9761-9774	JJ	denotes	complementary
T9674	9774-9776	,	denotes	,
T9675	9776-9779	CC	denotes	and
T9676	9780-9782	PRP	denotes	it
T9677	9783-9785	VBZ	denotes	is
T9678	9786-9794	JJ	denotes	possible
T9679	9795-9799	IN	denotes	that
T9680	9806-9810	VBZ	denotes	acts
T9681	9800-9805	NN	denotes	Tbx15
T9682	9811-9819	RB	denotes	directly
T9683	9820-9822	TO	denotes	to
T9684	9823-9830	VB	denotes	inhibit
T9685	9831-9837	NN	denotes	Agouti
T9686	9838-9851	NN	denotes	transcription
T9687	9852-9854	IN	denotes	in
T9688	9855-9867	JJ	denotes	dorsolateral
T9689	9868-9878	NN	denotes	mesenchyme
T9690	9878-9879	.	denotes	.
T9691	9879-10140	sentence	denotes	However, the ability of Tbx15 to suppress expression of the ventral-specific Agouti isoform in postnatal mice is likely to be indirect, since postnatal expression of Tbx15 occurs broadly along the dorsoventral axis and overlaps extensively with that of Agouti.
T9692	9880-9887	RB	denotes	However
T9693	9990-9992	VBZ	denotes	is
T9694	9887-9889	,	denotes	,
T9695	9889-9892	DT	denotes	the
T9696	9893-9900	NN	denotes	ability
T9697	9901-9903	IN	denotes	of
T9698	9904-9909	NN	denotes	Tbx15
T9699	9910-9912	TO	denotes	to
T9700	9913-9921	VB	denotes	suppress
T9701	9922-9932	NN	denotes	expression
T9702	9933-9935	IN	denotes	of
T9703	9936-9939	DT	denotes	the
T9704	9964-9971	NN	denotes	isoform
T9705	9940-9947	JJ	denotes	ventral
T9706	9948-9956	JJ	denotes	specific
T9707	9947-9948	HYPH	denotes	-
T9708	9957-9963	NN	denotes	Agouti
T9709	9972-9974	IN	denotes	in
T9710	9975-9984	JJ	denotes	postnatal
T9711	9985-9989	NNS	denotes	mice
T9712	9993-9999	JJ	denotes	likely
T9713	10000-10002	TO	denotes	to
T9714	10003-10005	VB	denotes	be
T9715	10006-10014	JJ	denotes	indirect
T9716	10014-10016	,	denotes	,
T9717	10016-10021	IN	denotes	since
T9718	10052-10058	VBZ	denotes	occurs
T9719	10022-10031	JJ	denotes	postnatal
T9720	10032-10042	NN	denotes	expression
T9721	10043-10045	IN	denotes	of
T9722	10046-10051	NN	denotes	Tbx15
T9723	10059-10066	RB	denotes	broadly
T9724	10067-10072	IN	denotes	along
T9725	10073-10076	DT	denotes	the
T9726	10090-10094	NN	denotes	axis
T9727	10077-10089	JJ	denotes	dorsoventral
T9728	10095-10098	CC	denotes	and
T9729	10099-10107	VBZ	denotes	overlaps
T9730	10108-10119	RB	denotes	extensively
T9731	10120-10124	IN	denotes	with
T9732	10125-10129	DT	denotes	that
T9733	10130-10132	IN	denotes	of
T9734	10133-10139	NN	denotes	Agouti
T9735	10139-10140	.	denotes	.
T9736	10140-10373	sentence	denotes	In either case, the targets of Tbx15 action in the skin include genes in addition to Agouti, since hair length and melanocyte distribution exhibit a demonstrable, albeit subtle, alteration in animals that carry a null Agouti allele.
T9737	10141-10143	IN	denotes	In
T9738	10197-10204	VBP	denotes	include
T9739	10144-10150	DT	denotes	either
T9740	10151-10155	NN	denotes	case
T9741	10155-10157	,	denotes	,
T9742	10157-10160	DT	denotes	the
T9743	10161-10168	NNS	denotes	targets
T9744	10169-10171	IN	denotes	of
T9745	10172-10177	NN	denotes	Tbx15
T9746	10178-10184	NN	denotes	action
T9747	10185-10187	IN	denotes	in
T9748	10188-10191	DT	denotes	the
T9749	10192-10196	NN	denotes	skin
T9750	10205-10210	NNS	denotes	genes
T9751	10211-10213	IN	denotes	in
T9752	10214-10222	NN	denotes	addition
T9753	10223-10225	IN	denotes	to
T9754	10226-10232	NN	denotes	Agouti
T9755	10232-10234	,	denotes	,
T9756	10234-10239	IN	denotes	since
T9757	10280-10287	VBP	denotes	exhibit
T9758	10240-10244	NN	denotes	hair
T9759	10245-10251	NN	denotes	length
T9760	10252-10255	CC	denotes	and
T9761	10256-10266	NN	denotes	melanocyte
T9762	10267-10279	NN	denotes	distribution
T9763	10288-10289	DT	denotes	a
T9764	10319-10329	NN	denotes	alteration
T9765	10290-10302	JJ	denotes	demonstrable
T9766	10302-10304	,	denotes	,
T9767	10304-10310	CC	denotes	albeit
T9768	10311-10317	JJ	denotes	subtle
T9769	10317-10319	,	denotes	,
T9770	10330-10332	IN	denotes	in
T9771	10333-10340	NNS	denotes	animals
T9772	10341-10345	WDT	denotes	that
T9773	10346-10351	VBP	denotes	carry
T9774	10352-10353	DT	denotes	a
T9775	10366-10372	NN	denotes	allele
T9776	10354-10358	JJ	denotes	null
T9777	10359-10365	NN	denotes	Agouti
T9778	10372-10373	.	denotes	.
T9779	10373-10640	sentence	denotes	One potential target is Alx4, which, like Agouti, is expressed in ventral embryonic mesenchyme, and, when mutated, affects hair-follicle as well as limb and craniofacial development (Qu et al. 1997, 1998; Wu et al. 2000; Wuyts et al. 2000; Mavrogiannis et al. 2001).
T9780	10374-10377	CD	denotes	One
T9781	10388-10394	NN	denotes	target
T9782	10378-10387	JJ	denotes	potential
T9783	10395-10397	VBZ	denotes	is
T9784	10398-10402	NN	denotes	Alx4
T9785	10402-10404	,	denotes	,
T9786	10404-10409	WDT	denotes	which
T9787	10427-10436	VBN	denotes	expressed
T9788	10409-10411	,	denotes	,
T9789	10411-10415	IN	denotes	like
T9790	10416-10422	NN	denotes	Agouti
T9791	10422-10424	,	denotes	,
T9792	10424-10426	VBZ	denotes	is
T9793	10437-10439	IN	denotes	in
T9794	10440-10447	JJ	denotes	ventral
T9795	10458-10468	NN	denotes	mesenchyme
T9796	10448-10457	JJ	denotes	embryonic
T9797	10468-10470	,	denotes	,
T9798	10470-10473	CC	denotes	and
T9799	10473-10475	,	denotes	,
T9800	10475-10479	WRB	denotes	when
T9801	10480-10487	VBN	denotes	mutated
T9802	10489-10496	VBZ	denotes	affects
T9803	10487-10489	,	denotes	,
T9804	10497-10501	NN	denotes	hair
T9805	10502-10510	NN	denotes	follicle
T9806	10501-10502	HYPH	denotes	-
T9807	10544-10555	NN	denotes	development
T9808	10511-10513	RB	denotes	as
T9809	10519-10521	IN	denotes	as
T9810	10514-10518	RB	denotes	well
T9811	10522-10526	NN	denotes	limb
T9812	10527-10530	CC	denotes	and
T9813	10531-10543	JJ	denotes	craniofacial
T9814	10556-10557	-LRB-	denotes	(
T9815	10557-10559	NNP	denotes	Qu
T9816	10560-10562	FW	denotes	et
T9817	10563-10566	FW	denotes	al.
T9818	10567-10571	CD	denotes	1997
T9819	10571-10573	,	denotes	,
T9820	10573-10577	CD	denotes	1998
T9821	10577-10578	:	denotes	;
T9822	10579-10581	NNP	denotes	Wu
T9823	10582-10584	FW	denotes	et
T9824	10585-10588	FW	denotes	al.
T9825	10589-10593	CD	denotes	2000
T9826	10593-10594	:	denotes	;
T9827	10595-10600	NNP	denotes	Wuyts
T9828	10601-10603	FW	denotes	et
T9829	10604-10607	FW	denotes	al.
T9830	10608-10612	CD	denotes	2000
T9831	10612-10613	:	denotes	;
T9832	10614-10626	NNP	denotes	Mavrogiannis
T9833	10627-10629	FW	denotes	et
T9834	10630-10633	FW	denotes	al.
T9835	10634-10638	CD	denotes	2001
T9836	10638-10639	-RRB-	denotes	)
T9837	10639-10640	.	denotes	.
T9838	10640-10790	sentence	denotes	However, expression of ventral markers such as Alx4, as well as Alx3 and Msx2, appears to be unaffected at E11.5 in deH/deH embryos (data not shown).
T9839	10641-10648	RB	denotes	However
T9840	10720-10727	VBZ	denotes	appears
T9841	10648-10650	,	denotes	,
T9842	10650-10660	NN	denotes	expression
T9843	10661-10663	IN	denotes	of
T9844	10664-10671	JJ	denotes	ventral
T9845	10672-10679	NNS	denotes	markers
T9846	10680-10684	JJ	denotes	such
T9847	10685-10687	IN	denotes	as
T9848	10688-10692	NN	denotes	Alx4
T9849	10692-10694	,	denotes	,
T9850	10694-10696	RB	denotes	as
T9851	10702-10704	IN	denotes	as
T9852	10697-10701	RB	denotes	well
T9853	10705-10709	NN	denotes	Alx3
T9854	10710-10713	CC	denotes	and
T9855	10714-10718	NN	denotes	Msx2
T9856	10718-10720	,	denotes	,
T9857	10728-10730	TO	denotes	to
T9858	10731-10733	VB	denotes	be
T9859	10734-10744	JJ	denotes	unaffected
T9860	10745-10747	IN	denotes	at
T9861	10748-10753	NN	denotes	E11.5
T9862	10754-10756	IN	denotes	in
T9863	10757-10760	NN	denotes	deH
T9864	10761-10764	NN	denotes	deH
T9865	10760-10761	HYPH	denotes	/
T9866	10765-10772	NNS	denotes	embryos
T9867	10773-10774	-LRB-	denotes	(
T9868	10783-10788	VBN	denotes	shown
T9869	10774-10778	NNS	denotes	data
T9870	10779-10782	RB	denotes	not
T9871	10788-10789	-RRB-	denotes	)
T9872	10789-10790	.	denotes	.
T10219	10792-10803	NNS	denotes	Differences
T10220	10804-10807	CC	denotes	and
T10221	10808-10820	NNS	denotes	Similarities
T10222	10821-10823	IN	denotes	to
T10223	10824-10836	JJ	denotes	Dorsoventral
T10224	10842-10852	NN	denotes	Patterning
T10225	10837-10841	NN	denotes	Limb
T10226	10852-11015	sentence	denotes	Loss of Tbx15 also affects regional distribution of hair color in the limbs, with areas that would normally produce black hair giving rise to yellow hair instead.
T10227	10853-10857	NN	denotes	Loss
T10228	10872-10879	VBZ	denotes	affects
T10229	10858-10860	IN	denotes	of
T10230	10861-10866	NN	denotes	Tbx15
T10231	10867-10871	RB	denotes	also
T10232	10880-10888	JJ	denotes	regional
T10233	10889-10901	NN	denotes	distribution
T10234	10902-10904	IN	denotes	of
T10235	10905-10909	NN	denotes	hair
T10236	10910-10915	NN	denotes	color
T10237	10916-10918	IN	denotes	in
T10238	10919-10922	DT	denotes	the
T10239	10923-10928	NNS	denotes	limbs
T10240	10928-10930	,	denotes	,
T10241	10930-10934	IN	denotes	with
T10242	10935-10940	NNS	denotes	areas
T10243	10980-10986	VBG	denotes	giving
T10244	10941-10945	WDT	denotes	that
T10245	10961-10968	VB	denotes	produce
T10246	10946-10951	MD	denotes	would
T10247	10952-10960	RB	denotes	normally
T10248	10969-10974	JJ	denotes	black
T10249	10975-10979	NN	denotes	hair
T10250	10987-10991	NN	denotes	rise
T10251	10992-10994	IN	denotes	to
T10252	10995-11001	JJ	denotes	yellow
T10253	11002-11006	NN	denotes	hair
T10254	11007-11014	RB	denotes	instead
T10255	11014-11015	.	denotes	.
T10256	11015-11173	sentence	denotes	However, neither normal patterns of pigment-type synthesis in the limb nor their disruption in deH/deH mice correspond to obvious developmental compartments.
T10257	11016-11023	RB	denotes	However
T10258	11124-11134	VBP	denotes	correspond
T10259	11023-11025	,	denotes	,
T10260	11025-11032	CC	denotes	neither
T10261	11040-11048	NNS	denotes	patterns
T10262	11033-11039	JJ	denotes	normal
T10263	11049-11051	IN	denotes	of
T10264	11052-11059	JJ	denotes	pigment
T10265	11060-11064	NN	denotes	type
T10266	11059-11060	HYPH	denotes	-
T10267	11065-11074	NN	denotes	synthesis
T10268	11075-11077	IN	denotes	in
T10269	11078-11081	DT	denotes	the
T10270	11082-11086	NN	denotes	limb
T10271	11087-11090	CC	denotes	nor
T10272	11091-11096	PRP$	denotes	their
T10273	11097-11107	NN	denotes	disruption
T10274	11108-11110	IN	denotes	in
T10275	11111-11114	NN	denotes	deH
T10276	11115-11118	NN	denotes	deH
T10277	11114-11115	HYPH	denotes	/
T10278	11119-11123	NNS	denotes	mice
T10279	11135-11137	IN	denotes	to
T10280	11138-11145	JJ	denotes	obvious
T10281	11160-11172	NNS	denotes	compartments
T10282	11146-11159	JJ	denotes	developmental
T10283	11172-11173	.	denotes	.
T10284	11173-11507	sentence	denotes	Furthermore, losses of function for En1 or Wnt7a, which cause a partial transformation of the distal limb from dorsum to ventrum (Loomis et al. 1996) or ventrum to dorsum (Parr and McMahon 1995), respectively, have no effect on regional patterns of Agouti expression or distribution of hair-color regions (Y. Chen, unpublished data).
T10285	11174-11185	RB	denotes	Furthermore
T10286	11384-11388	VBP	denotes	have
T10287	11185-11187	,	denotes	,
T10288	11187-11193	NNS	denotes	losses
T10289	11194-11196	IN	denotes	of
T10290	11197-11205	NN	denotes	function
T10291	11206-11209	IN	denotes	for
T10292	11210-11213	NN	denotes	En1
T10293	11214-11216	CC	denotes	or
T10294	11217-11222	NN	denotes	Wnt7a
T10295	11222-11224	,	denotes	,
T10296	11224-11229	WDT	denotes	which
T10297	11230-11235	VBP	denotes	cause
T10298	11236-11237	DT	denotes	a
T10299	11246-11260	NN	denotes	transformation
T10300	11238-11245	JJ	denotes	partial
T10301	11261-11263	IN	denotes	of
T10302	11264-11267	DT	denotes	the
T10303	11275-11279	NN	denotes	limb
T10304	11268-11274	JJ	denotes	distal
T10305	11280-11284	IN	denotes	from
T10306	11285-11291	NN	denotes	dorsum
T10307	11292-11294	IN	denotes	to
T10308	11295-11302	NN	denotes	ventrum
T10309	11303-11304	-LRB-	denotes	(
T10310	11304-11310	NNP	denotes	Loomis
T10311	11311-11313	FW	denotes	et
T10312	11314-11317	FW	denotes	al.
T10313	11318-11322	CD	denotes	1996
T10314	11322-11323	-RRB-	denotes	)
T10315	11324-11326	CC	denotes	or
T10316	11327-11334	NN	denotes	ventrum
T10317	11335-11337	IN	denotes	to
T10318	11338-11344	NN	denotes	dorsum
T10319	11345-11346	-LRB-	denotes	(
T10320	11346-11350	NNP	denotes	Parr
T10321	11351-11354	CC	denotes	and
T10322	11355-11362	NNP	denotes	McMahon
T10323	11363-11367	CD	denotes	1995
T10324	11367-11368	-RRB-	denotes	)
T10325	11368-11370	,	denotes	,
T10326	11370-11382	RB	denotes	respectively
T10327	11382-11384	,	denotes	,
T10328	11389-11391	DT	denotes	no
T10329	11392-11398	NN	denotes	effect
T10330	11399-11401	IN	denotes	on
T10331	11402-11410	JJ	denotes	regional
T10332	11411-11419	NNS	denotes	patterns
T10333	11420-11422	IN	denotes	of
T10334	11423-11429	NN	denotes	Agouti
T10335	11430-11440	NN	denotes	expression
T10336	11441-11443	CC	denotes	or
T10337	11444-11456	NN	denotes	distribution
T10338	11457-11459	IN	denotes	of
T10339	11460-11464	NN	denotes	hair
T10340	11465-11470	NN	denotes	color
T10341	11464-11465	HYPH	denotes	-
T10342	11471-11478	NNS	denotes	regions
T10343	11479-11480	-LRB-	denotes	(
T10344	11480-11482	NNP	denotes	Y.
T10345	11483-11487	NNP	denotes	Chen
T10346	11487-11489	,	denotes	,
T10347	11489-11500	JJ	denotes	unpublished
T10348	11501-11505	NNS	denotes	data
T10349	11505-11506	-RRB-	denotes	)
T10350	11506-11507	.	denotes	.
T10351	11507-11826	sentence	denotes	(Ectopic pigmentation of the ventral footpads that develops in En1 mutant mice is unrelated to pigment-type synthesis and instead likely reflects a requirement for En1, independent of Wnt7a, to repress migration or proliferation (or both) of pigment cells in ventral epidermis [Cygan et al. 1997; Loomis et al. 1998].)
T10352	11508-11509	-LRB-	denotes	(
T10353	11587-11589	VBZ	denotes	is
T10354	11509-11516	JJ	denotes	Ectopic
T10355	11517-11529	NN	denotes	pigmentation
T10356	11530-11532	IN	denotes	of
T10357	11533-11536	DT	denotes	the
T10358	11545-11553	NNS	denotes	footpads
T10359	11537-11544	JJ	denotes	ventral
T10360	11554-11558	WDT	denotes	that
T10361	11559-11567	VBZ	denotes	develops
T10362	11568-11570	IN	denotes	in
T10363	11571-11574	NN	denotes	En1
T10364	11582-11586	NNS	denotes	mice
T10365	11575-11581	NN	denotes	mutant
T10366	11590-11599	JJ	denotes	unrelated
T10367	11600-11602	IN	denotes	to
T10368	11603-11610	NN	denotes	pigment
T10369	11611-11615	NN	denotes	type
T10370	11610-11611	HYPH	denotes	-
T10371	11616-11625	NN	denotes	synthesis
T10372	11626-11629	CC	denotes	and
T10373	11630-11637	RB	denotes	instead
T10374	11645-11653	VBZ	denotes	reflects
T10375	11638-11644	RB	denotes	likely
T10376	11654-11655	DT	denotes	a
T10377	11656-11667	NN	denotes	requirement
T10378	11668-11671	IN	denotes	for
T10379	11672-11675	NN	denotes	En1
T10380	11675-11677	,	denotes	,
T10381	11677-11688	JJ	denotes	independent
T10382	11689-11691	IN	denotes	of
T10383	11692-11697	NN	denotes	Wnt7a
T10384	11697-11699	,	denotes	,
T10385	11699-11701	TO	denotes	to
T10386	11702-11709	VB	denotes	repress
T10387	11710-11719	NN	denotes	migration
T10388	11720-11722	CC	denotes	or
T10389	11723-11736	NN	denotes	proliferation
T10390	11737-11738	-LRB-	denotes	(
T10391	11738-11740	CC	denotes	or
T10392	11741-11745	DT	denotes	both
T10393	11745-11746	-RRB-	denotes	)
T10394	11747-11749	IN	denotes	of
T10395	11750-11757	NN	denotes	pigment
T10396	11758-11763	NNS	denotes	cells
T10397	11764-11766	IN	denotes	in
T10398	11767-11774	JJ	denotes	ventral
T10399	11775-11784	NN	denotes	epidermis
T10400	11785-11786	-LRB-	denotes	[
T10401	11786-11791	NNP	denotes	Cygan
T10402	11792-11794	FW	denotes	et
T10403	11795-11798	FW	denotes	al.
T10404	11799-11803	CD	denotes	1997
T10405	11803-11804	:	denotes	;
T10406	11805-11811	NNP	denotes	Loomis
T10407	11812-11814	FW	denotes	et
T10408	11815-11818	FW	denotes	al.
T10409	11819-11823	CD	denotes	1998
T10410	11823-11824	-RRB-	denotes	]
T10411	11824-11825	.	denotes	.
T10412	11825-11826	-RRB-	denotes	)
T10413	11826-12184	sentence	denotes	These considerations notwithstanding, control of dorsoventral trunk pattern by Tbx15 shares certain features with control of dorsoventral limb patterning by Lmx1b, a LIM domain transcription factor that acts downstream of Wnt7a and En1 (Riddle et al. 1995; Vogel et al. 1995; Cygan et al. 1997; Logan et al. 1997; Loomis et al. 1998; Chen and Johnson 2002).
T10414	11827-11832	DT	denotes	These
T10415	11833-11847	NNS	denotes	considerations
T10416	11848-11863	RB	denotes	notwithstanding
T10417	11912-11918	VBZ	denotes	shares
T10418	11863-11865	,	denotes	,
T10419	11865-11872	NN	denotes	control
T10420	11873-11875	IN	denotes	of
T10421	11876-11888	JJ	denotes	dorsoventral
T10422	11895-11902	NN	denotes	pattern
T10423	11889-11894	NN	denotes	trunk
T10424	11903-11905	IN	denotes	by
T10425	11906-11911	NN	denotes	Tbx15
T10426	11919-11926	JJ	denotes	certain
T10427	11927-11935	NNS	denotes	features
T10428	11936-11940	IN	denotes	with
T10429	11941-11948	NN	denotes	control
T10430	11949-11951	IN	denotes	of
T10431	11952-11964	JJ	denotes	dorsoventral
T10432	11970-11980	NN	denotes	patterning
T10433	11965-11969	NN	denotes	limb
T10434	11981-11983	IN	denotes	by
T10435	11984-11989	NN	denotes	Lmx1b
T10436	11989-11991	,	denotes	,
T10437	11991-11992	DT	denotes	a
T10438	12018-12024	NN	denotes	factor
T10439	11993-11996	NN	denotes	LIM
T10440	11997-12003	NN	denotes	domain
T10441	12004-12017	NN	denotes	transcription
T10442	12025-12029	WDT	denotes	that
T10443	12030-12034	VBZ	denotes	acts
T10444	12035-12045	RB	denotes	downstream
T10445	12046-12048	IN	denotes	of
T10446	12049-12054	NN	denotes	Wnt7a
T10447	12055-12058	CC	denotes	and
T10448	12059-12062	NN	denotes	En1
T10449	12063-12064	-LRB-	denotes	(
T10450	12064-12070	NNP	denotes	Riddle
T10451	12071-12073	FW	denotes	et
T10452	12074-12077	FW	denotes	al.
T10453	12078-12082	CD	denotes	1995
T10454	12082-12083	:	denotes	;
T10455	12084-12089	NNP	denotes	Vogel
T10456	12090-12092	FW	denotes	et
T10457	12093-12096	FW	denotes	al.
T10458	12097-12101	CD	denotes	1995
T10459	12101-12102	:	denotes	;
T10460	12103-12108	NNP	denotes	Cygan
T10461	12109-12111	FW	denotes	et
T10462	12112-12115	FW	denotes	al.
T10463	12116-12120	CD	denotes	1997
T10464	12120-12121	:	denotes	;
T10465	12122-12127	NNP	denotes	Logan
T10466	12128-12130	FW	denotes	et
T10467	12131-12134	FW	denotes	al.
T10468	12135-12139	CD	denotes	1997
T10469	12139-12140	:	denotes	;
T10470	12141-12147	NNP	denotes	Loomis
T10471	12148-12150	FW	denotes	et
T10472	12151-12154	FW	denotes	al.
T10473	12155-12159	CD	denotes	1998
T10474	12159-12160	:	denotes	;
T10475	12161-12165	NNP	denotes	Chen
T10476	12166-12169	CC	denotes	and
T10477	12170-12177	NNP	denotes	Johnson
T10478	12178-12182	CD	denotes	2002
T10479	12182-12183	-RRB-	denotes	)
T10480	12183-12184	.	denotes	.
T10481	12184-12438	sentence	denotes	Both Tbx15 and Lmx1b act autonomously in mesenchymal cells to promote a dorsal identity, yet have expression domains that do not correspond to cell lineage compartments in the flank (Tbx15) or the limb (Lmx1b) (Altabef et al. 1997; Michaud et al. 1997).
T10482	12185-12189	CC	denotes	Both
T10483	12190-12195	NN	denotes	Tbx15
T10484	12206-12209	VBP	denotes	act
T10485	12196-12199	CC	denotes	and
T10486	12200-12205	NN	denotes	Lmx1b
T10487	12210-12222	RB	denotes	autonomously
T10488	12223-12225	IN	denotes	in
T10489	12226-12237	JJ	denotes	mesenchymal
T10490	12238-12243	NNS	denotes	cells
T10491	12244-12246	TO	denotes	to
T10492	12247-12254	VB	denotes	promote
T10493	12255-12256	DT	denotes	a
T10494	12264-12272	NN	denotes	identity
T10495	12257-12263	JJ	denotes	dorsal
T10496	12272-12274	,	denotes	,
T10497	12274-12277	CC	denotes	yet
T10498	12278-12282	VBP	denotes	have
T10499	12283-12293	NN	denotes	expression
T10500	12294-12301	NNS	denotes	domains
T10501	12302-12306	WDT	denotes	that
T10502	12314-12324	VB	denotes	correspond
T10503	12307-12309	VBP	denotes	do
T10504	12310-12313	RB	denotes	not
T10505	12325-12327	IN	denotes	to
T10506	12328-12332	NN	denotes	cell
T10507	12333-12340	NN	denotes	lineage
T10508	12341-12353	NNS	denotes	compartments
T10509	12354-12356	IN	denotes	in
T10510	12357-12360	DT	denotes	the
T10511	12361-12366	NN	denotes	flank
T10512	12367-12368	-LRB-	denotes	(
T10513	12368-12373	NN	denotes	Tbx15
T10514	12373-12374	-RRB-	denotes	)
T10515	12375-12377	CC	denotes	or
T10516	12378-12381	DT	denotes	the
T10517	12382-12386	NN	denotes	limb
T10518	12387-12388	-LRB-	denotes	(
T10519	12388-12393	NN	denotes	Lmx1b
T10520	12393-12394	-RRB-	denotes	)
T10521	12395-12396	-LRB-	denotes	(
T10522	12396-12403	NNP	denotes	Altabef
T10523	12404-12406	FW	denotes	et
T10524	12407-12410	FW	denotes	al.
T10525	12411-12415	CD	denotes	1997
T10526	12415-12416	:	denotes	;
T10527	12417-12424	NNP	denotes	Michaud
T10528	12425-12427	FW	denotes	et
T10529	12428-12431	FW	denotes	al.
T10530	12432-12436	CD	denotes	1997
T10531	12436-12437	-RRB-	denotes	)
T10532	12437-12438	.	denotes	.
T10533	12438-12614	sentence	denotes	In the case of Lmx1b, its expression in the distal limb depends on Wnt7a produced in the overlying dorsal ectoderm (Riddle et al. 1995; Cygan et al. 1997; Loomis et al. 1998).
T10534	12439-12441	IN	denotes	In
T10535	12495-12502	VBZ	denotes	depends
T10536	12442-12445	DT	denotes	the
T10537	12446-12450	NN	denotes	case
T10538	12451-12453	IN	denotes	of
T10539	12454-12459	NN	denotes	Lmx1b
T10540	12459-12461	,	denotes	,
T10541	12461-12464	PRP$	denotes	its
T10542	12465-12475	NN	denotes	expression
T10543	12476-12478	IN	denotes	in
T10544	12479-12482	DT	denotes	the
T10545	12490-12494	NN	denotes	limb
T10546	12483-12489	JJ	denotes	distal
T10547	12503-12505	IN	denotes	on
T10548	12506-12511	NN	denotes	Wnt7a
T10549	12512-12520	VBN	denotes	produced
T10550	12521-12523	IN	denotes	in
T10551	12524-12527	DT	denotes	the
T10552	12545-12553	NN	denotes	ectoderm
T10553	12528-12537	VBG	denotes	overlying
T10554	12538-12544	JJ	denotes	dorsal
T10555	12554-12555	-LRB-	denotes	(
T10556	12555-12561	NNP	denotes	Riddle
T10557	12562-12564	FW	denotes	et
T10558	12565-12568	FW	denotes	al.
T10559	12569-12573	CD	denotes	1995
T10560	12573-12574	:	denotes	;
T10561	12575-12580	NNP	denotes	Cygan
T10562	12581-12583	FW	denotes	et
T10563	12584-12587	FW	denotes	al.
T10564	12588-12592	CD	denotes	1997
T10565	12592-12593	:	denotes	;
T10566	12594-12600	NNP	denotes	Loomis
T10567	12601-12603	FW	denotes	et
T10568	12604-12607	FW	denotes	al.
T10569	12608-12612	CD	denotes	1998
T10570	12612-12613	-RRB-	denotes	)
T10571	12613-12614	.	denotes	.
T10572	12614-12932	sentence	denotes	Wnt7a, in turn, is restricted to dorsal ectoderm by En1 in the ventral ectoderm (Loomis et al. 1996; Cygan et al. 1997; Logan et al. 1997), whose expression marks a lineage boundary coincident with the dorsoventral midline of the apical ectodermal ridge (Altabef et al. 1997; Michaud et al. 1997; Kimmel et al. 2000).
T10573	12615-12620	NN	denotes	Wnt7a
T10574	12634-12644	VBN	denotes	restricted
T10575	12620-12622	,	denotes	,
T10576	12622-12624	IN	denotes	in
T10577	12625-12629	NN	denotes	turn
T10578	12629-12631	,	denotes	,
T10579	12631-12633	VBZ	denotes	is
T10580	12645-12647	IN	denotes	to
T10581	12648-12654	JJ	denotes	dorsal
T10582	12655-12663	NN	denotes	ectoderm
T10583	12664-12666	IN	denotes	by
T10584	12667-12670	NN	denotes	En1
T10585	12671-12673	IN	denotes	in
T10586	12674-12677	DT	denotes	the
T10587	12686-12694	NN	denotes	ectoderm
T10588	12678-12685	JJ	denotes	ventral
T10589	12695-12696	-LRB-	denotes	(
T10590	12696-12702	NNP	denotes	Loomis
T10591	12703-12705	FW	denotes	et
T10592	12706-12709	FW	denotes	al.
T10593	12710-12714	CD	denotes	1996
T10594	12714-12715	:	denotes	;
T10595	12716-12721	NNP	denotes	Cygan
T10596	12722-12724	FW	denotes	et
T10597	12725-12728	FW	denotes	al.
T10598	12729-12733	CD	denotes	1997
T10599	12733-12734	:	denotes	;
T10600	12735-12740	NNP	denotes	Logan
T10601	12741-12743	FW	denotes	et
T10602	12744-12747	FW	denotes	al.
T10603	12748-12752	CD	denotes	1997
T10604	12752-12753	-RRB-	denotes	)
T10605	12753-12755	,	denotes	,
T10606	12755-12760	WP$	denotes	whose
T10607	12761-12771	NN	denotes	expression
T10608	12772-12777	VBZ	denotes	marks
T10609	12778-12779	DT	denotes	a
T10610	12788-12796	NN	denotes	boundary
T10611	12780-12787	NN	denotes	lineage
T10612	12797-12807	JJ	denotes	coincident
T10613	12808-12812	IN	denotes	with
T10614	12813-12816	DT	denotes	the
T10615	12830-12837	NN	denotes	midline
T10616	12817-12829	JJ	denotes	dorsoventral
T10617	12838-12840	IN	denotes	of
T10618	12841-12844	DT	denotes	the
T10619	12863-12868	NN	denotes	ridge
T10620	12845-12851	JJ	denotes	apical
T10621	12852-12862	JJ	denotes	ectodermal
T10622	12869-12870	-LRB-	denotes	(
T10623	12891-12898	NNP	denotes	Michaud
T10624	12870-12877	NN	denotes	Altabef
T10625	12878-12880	FW	denotes	et
T10626	12881-12884	FW	denotes	al.
T10627	12885-12889	CD	denotes	1997
T10628	12889-12890	:	denotes	;
T10629	12899-12901	FW	denotes	et
T10630	12902-12905	FW	denotes	al.
T10631	12906-12910	CD	denotes	1997
T10632	12910-12911	:	denotes	;
T10633	12912-12918	NNP	denotes	Kimmel
T10634	12919-12921	FW	denotes	et
T10635	12922-12925	FW	denotes	al.
T10636	12926-12930	CD	denotes	2000
T10637	12930-12931	-RRB-	denotes	)
T10638	12931-12932	.	denotes	.
T10639	12932-13124	sentence	denotes	As described above, En1 or Wnt7a mutations have not been reported to affect patterns of hair-color distribution (C. Loomis, personal communication; Parr and McMahon 1995; Loomis et al. 1996).
T10640	12933-12935	IN	denotes	As
T10641	12936-12945	VBN	denotes	described
T10642	12990-12998	VBN	denotes	reported
T10643	12946-12951	RB	denotes	above
T10644	12951-12953	,	denotes	,
T10645	12953-12956	NN	denotes	En1
T10646	12966-12975	NNS	denotes	mutations
T10647	12957-12959	CC	denotes	or
T10648	12960-12965	NN	denotes	Wnt7a
T10649	12976-12980	VBP	denotes	have
T10650	12981-12984	RB	denotes	not
T10651	12985-12989	VBN	denotes	been
T10652	12999-13001	TO	denotes	to
T10653	13002-13008	VB	denotes	affect
T10654	13009-13017	NNS	denotes	patterns
T10655	13018-13020	IN	denotes	of
T10656	13021-13025	NN	denotes	hair
T10657	13026-13031	NN	denotes	color
T10658	13025-13026	HYPH	denotes	-
T10659	13032-13044	NN	denotes	distribution
T10660	13045-13046	-LRB-	denotes	(
T10661	13046-13048	NNP	denotes	C.
T10662	13049-13055	NNP	denotes	Loomis
T10663	13055-13057	,	denotes	,
T10664	13057-13065	JJ	denotes	personal
T10665	13066-13079	NN	denotes	communication
T10666	13079-13080	:	denotes	;
T10667	13081-13085	NNP	denotes	Parr
T10668	13086-13089	CC	denotes	and
T10669	13090-13097	NNP	denotes	McMahon
T10670	13098-13102	CD	denotes	1995
T10671	13102-13103	:	denotes	;
T10672	13104-13110	NNP	denotes	Loomis
T10673	13111-13113	FW	denotes	et
T10674	13114-13117	RB	denotes	al.
T10675	13118-13122	CD	denotes	1996
T10676	13122-13123	-RRB-	denotes	)
T10677	13123-13124	.	denotes	.
T10678	13124-13296	sentence	denotes	However, the essential theme that ectodermal lineage compartments control the fate of underlying mesenchyme in developing limbs may apply to the trunk as well as the limb.
T10679	13125-13132	RB	denotes	However
T10680	13257-13262	VB	denotes	apply
T10681	13132-13134	,	denotes	,
T10682	13134-13137	DT	denotes	the
T10683	13148-13153	NN	denotes	theme
T10684	13138-13147	JJ	denotes	essential
T10685	13154-13158	IN	denotes	that
T10686	13191-13198	VBP	denotes	control
T10687	13159-13169	JJ	denotes	ectodermal
T10688	13178-13190	NNS	denotes	compartments
T10689	13170-13177	NN	denotes	lineage
T10690	13199-13202	DT	denotes	the
T10691	13203-13207	NN	denotes	fate
T10692	13208-13210	IN	denotes	of
T10693	13211-13221	VBG	denotes	underlying
T10694	13222-13232	NN	denotes	mesenchyme
T10695	13233-13235	IN	denotes	in
T10696	13236-13246	VBG	denotes	developing
T10697	13247-13252	NNS	denotes	limbs
T10698	13253-13256	MD	denotes	may
T10699	13263-13265	IN	denotes	to
T10700	13266-13269	DT	denotes	the
T10701	13270-13275	NN	denotes	trunk
T10702	13276-13278	RB	denotes	as
T10703	13284-13286	IN	denotes	as
T10704	13279-13283	RB	denotes	well
T10705	13287-13290	DT	denotes	the
T10706	13291-13295	NN	denotes	limb
T10707	13295-13296	.	denotes	.
T10708	13296-13418	sentence	denotes	The mammary glands also develop at a stereotyped dorsoventral position and depend on epithelial–mesenchymal interactions.
T10709	13297-13300	DT	denotes	The
T10710	13309-13315	NNS	denotes	glands
T10711	13301-13308	JJ	denotes	mammary
T10712	13321-13328	VBP	denotes	develop
T10713	13316-13320	RB	denotes	also
T10714	13329-13331	IN	denotes	at
T10715	13332-13333	DT	denotes	a
T10716	13359-13367	NN	denotes	position
T10717	13334-13345	JJ	denotes	stereotyped
T10718	13346-13358	JJ	denotes	dorsoventral
T10719	13368-13371	CC	denotes	and
T10720	13372-13378	VBP	denotes	depend
T10721	13379-13381	IN	denotes	on
T10722	13382-13392	JJ	denotes	epithelial
T10723	13393-13404	JJ	denotes	mesenchymal
T10724	13392-13393	HYPH	denotes	–
T10725	13405-13417	NNS	denotes	interactions
T10726	13417-13418	.	denotes	.
T10727	13418-13638	sentence	denotes	However, the number and apparent position of the mammary glands are normal in deH/deH animals, indicating the existence of additional mechanisms that control dorsoventral patterning in the trunk as well as in the limbs.
T10728	13419-13426	RB	denotes	However
T10729	13483-13486	VBP	denotes	are
T10730	13426-13428	,	denotes	,
T10731	13428-13431	DT	denotes	the
T10732	13432-13438	NN	denotes	number
T10733	13439-13442	CC	denotes	and
T10734	13443-13451	JJ	denotes	apparent
T10735	13452-13460	NN	denotes	position
T10736	13461-13463	IN	denotes	of
T10737	13464-13467	DT	denotes	the
T10738	13476-13482	NNS	denotes	glands
T10739	13468-13475	JJ	denotes	mammary
T10740	13487-13493	JJ	denotes	normal
T10741	13494-13496	IN	denotes	in
T10742	13497-13500	NN	denotes	deH
T10743	13501-13504	NN	denotes	deH
T10744	13500-13501	HYPH	denotes	/
T10745	13505-13512	NNS	denotes	animals
T10746	13512-13514	,	denotes	,
T10747	13514-13524	VBG	denotes	indicating
T10748	13525-13528	DT	denotes	the
T10749	13529-13538	NN	denotes	existence
T10750	13539-13541	IN	denotes	of
T10751	13542-13552	JJ	denotes	additional
T10752	13553-13563	NNS	denotes	mechanisms
T10753	13564-13568	WDT	denotes	that
T10754	13569-13576	VBP	denotes	control
T10755	13577-13589	JJ	denotes	dorsoventral
T10756	13590-13600	NN	denotes	patterning
T10757	13601-13603	IN	denotes	in
T10758	13604-13607	DT	denotes	the
T10759	13608-13613	NN	denotes	trunk
T10760	13614-13616	RB	denotes	as
T10761	13622-13624	IN	denotes	as
T10762	13617-13621	RB	denotes	well
T10763	13625-13627	IN	denotes	in
T10764	13628-13631	DT	denotes	the
T10765	13632-13637	NNS	denotes	limbs
T10766	13637-13638	.	denotes	.
T10767	13638-13698	sentence	denotes	These ideas are summarized in the model shown in Figure 9B.
T10768	13639-13644	DT	denotes	These
T10769	13645-13650	NNS	denotes	ideas
T10770	13655-13665	VBN	denotes	summarized
T10771	13651-13654	VBP	denotes	are
T10772	13666-13668	IN	denotes	in
T10773	13669-13672	DT	denotes	the
T10774	13673-13678	NN	denotes	model
T10775	13679-13684	VBN	denotes	shown
T10776	13685-13687	IN	denotes	in
T10777	13688-13694	NN	denotes	Figure
T10778	13695-13697	CD	denotes	9B
T10779	13697-13698	.	denotes	.
T10780	13698-14002	sentence	denotes	We speculate that a diffusible signal from dorsal trunk ectoderm, at or prior to E11.5, promotes expression of Tbx15 in dorsal trunk mesenchyme, which then establishes dorsal positional identity of those cells as manifested by differences in Agouti expression, pigment-cell development, and hair growth.
T10781	13699-13701	PRP	denotes	We
T10782	13702-13711	VBP	denotes	speculate
T10783	13712-13716	IN	denotes	that
T10784	13787-13795	VBZ	denotes	promotes
T10785	13717-13718	DT	denotes	a
T10786	13730-13736	NN	denotes	signal
T10787	13719-13729	JJ	denotes	diffusible
T10788	13737-13741	IN	denotes	from
T10789	13742-13748	JJ	denotes	dorsal
T10790	13755-13763	NN	denotes	ectoderm
T10791	13749-13754	NN	denotes	trunk
T10792	13763-13765	,	denotes	,
T10793	13765-13767	IN	denotes	at
T10794	13768-13770	CC	denotes	or
T10795	13771-13776	RB	denotes	prior
T10796	13780-13785	NN	denotes	E11.5
T10797	13777-13779	IN	denotes	to
T10798	13785-13787	,	denotes	,
T10799	13796-13806	NN	denotes	expression
T10800	13807-13809	IN	denotes	of
T10801	13810-13815	NN	denotes	Tbx15
T10802	13816-13818	IN	denotes	in
T10803	13819-13825	JJ	denotes	dorsal
T10804	13832-13842	NN	denotes	mesenchyme
T10805	13826-13831	NN	denotes	trunk
T10806	13842-13844	,	denotes	,
T10807	13844-13849	WDT	denotes	which
T10808	13855-13866	VBZ	denotes	establishes
T10809	13850-13854	RB	denotes	then
T10810	13867-13873	JJ	denotes	dorsal
T10811	13885-13893	NN	denotes	identity
T10812	13874-13884	JJ	denotes	positional
T10813	13894-13896	IN	denotes	of
T10814	13897-13902	DT	denotes	those
T10815	13903-13908	NNS	denotes	cells
T10816	13909-13911	IN	denotes	as
T10817	13912-13922	VBN	denotes	manifested
T10818	13923-13925	IN	denotes	by
T10819	13926-13937	NNS	denotes	differences
T10820	13938-13940	IN	denotes	in
T10821	13941-13947	NN	denotes	Agouti
T10822	13948-13958	NN	denotes	expression
T10823	13958-13960	,	denotes	,
T10824	13960-13967	NN	denotes	pigment
T10825	13968-13972	NN	denotes	cell
T10826	13967-13968	HYPH	denotes	-
T10827	13973-13984	NN	denotes	development
T10828	13984-13986	,	denotes	,
T10829	13986-13989	CC	denotes	and
T10830	13990-13994	NN	denotes	hair
T10831	13995-14001	NN	denotes	growth
T10832	14001-14002	.	denotes	.
T10833	14002-14348	sentence	denotes	Because the ventral limit of Tbx15 expression corresponds to the dorsal limit of En1 expression and because the normal position of the pigmentation boundary lies approximately in register with the limb-bud outgrowths, we depict the position of a putative dorsoventral boundary in trunk ectoderm as coincident with the limb dorsoventral boundary.
T10834	14003-14010	IN	denotes	Because
T10835	14049-14060	VBZ	denotes	corresponds
T10836	14011-14014	DT	denotes	the
T10837	14023-14028	NN	denotes	limit
T10838	14015-14022	JJ	denotes	ventral
T10839	14029-14031	IN	denotes	of
T10840	14032-14037	NN	denotes	Tbx15
T10841	14038-14048	NN	denotes	expression
T10842	14224-14230	VBP	denotes	depict
T10843	14061-14063	IN	denotes	to
T10844	14064-14067	DT	denotes	the
T10845	14075-14080	NN	denotes	limit
T10846	14068-14074	JJ	denotes	dorsal
T10847	14081-14083	IN	denotes	of
T10848	14084-14087	NN	denotes	En1
T10849	14088-14098	NN	denotes	expression
T10850	14099-14102	CC	denotes	and
T10851	14103-14110	IN	denotes	because
T10852	14160-14164	VBZ	denotes	lies
T10853	14111-14114	DT	denotes	the
T10854	14122-14130	NN	denotes	position
T10855	14115-14121	JJ	denotes	normal
T10856	14131-14133	IN	denotes	of
T10857	14134-14137	DT	denotes	the
T10858	14151-14159	NN	denotes	boundary
T10859	14138-14150	NN	denotes	pigmentation
T10860	14165-14178	RB	denotes	approximately
T10861	14179-14181	IN	denotes	in
T10862	14182-14190	NN	denotes	register
T10863	14191-14195	IN	denotes	with
T10864	14196-14199	DT	denotes	the
T10865	14209-14219	NNS	denotes	outgrowths
T10866	14200-14204	NN	denotes	limb
T10867	14205-14208	NN	denotes	bud
T10868	14204-14205	HYPH	denotes	-
T10869	14219-14221	,	denotes	,
T10870	14221-14223	PRP	denotes	we
T10871	14231-14234	DT	denotes	the
T10872	14235-14243	NN	denotes	position
T10873	14244-14246	IN	denotes	of
T10874	14247-14248	DT	denotes	a
T10875	14271-14279	NN	denotes	boundary
T10876	14249-14257	JJ	denotes	putative
T10877	14258-14270	JJ	denotes	dorsoventral
T10878	14280-14282	IN	denotes	in
T10879	14283-14288	NN	denotes	trunk
T10880	14289-14297	NN	denotes	ectoderm
T10881	14298-14300	IN	denotes	as
T10882	14301-14311	JJ	denotes	coincident
T10883	14312-14316	IN	denotes	with
T10884	14317-14320	DT	denotes	the
T10885	14339-14347	NN	denotes	boundary
T10886	14321-14325	NN	denotes	limb
T10887	14326-14338	JJ	denotes	dorsoventral
T10888	14347-14348	.	denotes	.
T10889	14348-14681	sentence	denotes	This model is consistent with studies in the chick, where distinct dorsal and ventral lineage compartments exist for ectoderm in both the limb (Altabef et al. 1997, 2000; Michaud et al. 1997; Kimmel et al. 2000) and interlimb regions (Altabef et al. 1997, 2000), but not for limb mesoderm (Altabef et al. 1997; Michaud et al. 1997).
T10890	14349-14353	DT	denotes	This
T10891	14354-14359	NN	denotes	model
T10892	14360-14362	VBZ	denotes	is
T10893	14363-14373	JJ	denotes	consistent
T10894	14374-14378	IN	denotes	with
T10895	14379-14386	NNS	denotes	studies
T10896	14387-14389	IN	denotes	in
T10897	14390-14393	DT	denotes	the
T10898	14394-14399	NN	denotes	chick
T10899	14399-14401	,	denotes	,
T10900	14401-14406	WRB	denotes	where
T10901	14456-14461	VBP	denotes	exist
T10902	14407-14415	JJ	denotes	distinct
T10903	14443-14455	NNS	denotes	compartments
T10904	14416-14422	JJ	denotes	dorsal
T10905	14423-14426	CC	denotes	and
T10906	14427-14434	JJ	denotes	ventral
T10907	14435-14442	NN	denotes	lineage
T10908	14462-14465	IN	denotes	for
T10909	14466-14474	NN	denotes	ectoderm
T10910	14475-14477	IN	denotes	in
T10911	14478-14482	CC	denotes	both
T10912	14487-14491	NN	denotes	limb
T10913	14483-14486	DT	denotes	the
T10914	14492-14493	-LRB-	denotes	(
T10915	14520-14527	NNP	denotes	Michaud
T10916	14493-14500	NN	denotes	Altabef
T10917	14501-14503	FW	denotes	et
T10918	14504-14507	FW	denotes	al.
T10919	14508-14512	CD	denotes	1997
T10920	14512-14514	,	denotes	,
T10921	14514-14518	CD	denotes	2000
T10922	14518-14519	:	denotes	;
T10923	14528-14530	FW	denotes	et
T10924	14531-14534	FW	denotes	al.
T10925	14535-14539	CD	denotes	1997
T10926	14539-14540	:	denotes	;
T10927	14541-14547	NNP	denotes	Kimmel
T10928	14548-14550	FW	denotes	et
T10929	14551-14554	FW	denotes	al.
T10930	14555-14559	CD	denotes	2000
T10931	14559-14560	-RRB-	denotes	)
T10932	14561-14564	CC	denotes	and
T10933	14565-14574	JJ	denotes	interlimb
T10934	14575-14582	NNS	denotes	regions
T10935	14583-14584	-LRB-	denotes	(
T10936	14584-14591	NNP	denotes	Altabef
T10937	14592-14594	FW	denotes	et
T10938	14595-14598	FW	denotes	al.
T10939	14599-14603	CD	denotes	1997
T10940	14603-14605	,	denotes	,
T10941	14605-14609	CD	denotes	2000
T10942	14609-14610	-RRB-	denotes	)
T10943	14610-14612	,	denotes	,
T10944	14612-14615	CC	denotes	but
T10945	14620-14623	IN	denotes	for
T10946	14616-14619	RB	denotes	not
T10947	14624-14628	NN	denotes	limb
T10948	14629-14637	NN	denotes	mesoderm
T10949	14638-14639	-LRB-	denotes	(
T10950	14639-14646	NNP	denotes	Altabef
T10951	14647-14649	FW	denotes	et
T10952	14650-14653	FW	denotes	al.
T10953	14654-14658	CD	denotes	1997
T10954	14658-14659	:	denotes	;
T10955	14660-14667	NNP	denotes	Michaud
T10956	14668-14670	FW	denotes	et
T10957	14671-14674	FW	denotes	al.
T10958	14675-14679	CD	denotes	1997
T10959	14679-14680	-RRB-	denotes	)
T10960	14680-14681	.	denotes	.
T10961	14681-15118	sentence	denotes	In fact, the same mechanism that determines dorsoventral position of the limbs and the apical ectodermal ridge may also act on expression of Tbx15 in the trunk, since ectopic limbs induced in the interlimb region by application of FGF beads develop along a single line that is coincident with normal limb buds (and the future pigmentation boundary) (Cohn et al. 1995; Crossley et al. 1996; Vogel et al. 1996; Altabef et al. 1997, 2000).
T10962	14682-14684	IN	denotes	In
T10963	14802-14805	VB	denotes	act
T10964	14685-14689	NN	denotes	fact
T10965	14689-14691	,	denotes	,
T10966	14691-14694	DT	denotes	the
T10967	14700-14709	NN	denotes	mechanism
T10968	14695-14699	JJ	denotes	same
T10969	14710-14714	WDT	denotes	that
T10970	14715-14725	VBZ	denotes	determines
T10971	14726-14738	JJ	denotes	dorsoventral
T10972	14739-14747	NN	denotes	position
T10973	14748-14750	IN	denotes	of
T10974	14751-14754	DT	denotes	the
T10975	14755-14760	NNS	denotes	limbs
T10976	14761-14764	CC	denotes	and
T10977	14765-14768	DT	denotes	the
T10978	14787-14792	NN	denotes	ridge
T10979	14769-14775	JJ	denotes	apical
T10980	14776-14786	JJ	denotes	ectodermal
T10981	14793-14796	MD	denotes	may
T10982	14797-14801	RB	denotes	also
T10983	14806-14808	IN	denotes	on
T10984	14809-14819	NN	denotes	expression
T10985	14820-14822	IN	denotes	of
T10986	14823-14828	NN	denotes	Tbx15
T10987	14829-14831	IN	denotes	in
T10988	14832-14835	DT	denotes	the
T10989	14836-14841	NN	denotes	trunk
T10990	14841-14843	,	denotes	,
T10991	14843-14848	IN	denotes	since
T10992	14923-14930	VBP	denotes	develop
T10993	14849-14856	JJ	denotes	ectopic
T10994	14857-14862	NNS	denotes	limbs
T10995	14863-14870	VBN	denotes	induced
T10996	14871-14873	IN	denotes	in
T10997	14874-14877	DT	denotes	the
T10998	14888-14894	NN	denotes	region
T10999	14878-14887	JJ	denotes	interlimb
T11000	14895-14897	IN	denotes	by
T11001	14898-14909	NN	denotes	application
T11002	14910-14912	IN	denotes	of
T11003	14913-14916	NN	denotes	FGF
T11004	14917-14922	NNS	denotes	beads
T11005	14931-14936	IN	denotes	along
T11006	14937-14938	DT	denotes	a
T11007	14946-14950	NN	denotes	line
T11008	14939-14945	JJ	denotes	single
T11009	14951-14955	WDT	denotes	that
T11010	14956-14958	VBZ	denotes	is
T11011	14959-14969	JJ	denotes	coincident
T11012	14970-14974	IN	denotes	with
T11013	14975-14981	JJ	denotes	normal
T11014	14987-14991	NNS	denotes	buds
T11015	14982-14986	NN	denotes	limb
T11016	14992-14993	-LRB-	denotes	(
T11017	14993-14996	CC	denotes	and
T11018	14997-15000	DT	denotes	the
T11019	15021-15029	NN	denotes	boundary
T11020	15001-15007	JJ	denotes	future
T11021	15008-15020	NN	denotes	pigmentation
T11022	15029-15030	-RRB-	denotes	)
T11023	15031-15032	-LRB-	denotes	(
T11024	15032-15036	NNP	denotes	Cohn
T11025	15037-15039	FW	denotes	et
T11026	15040-15043	FW	denotes	al.
T11027	15044-15048	CD	denotes	1995
T11028	15048-15049	:	denotes	;
T11029	15050-15058	NNP	denotes	Crossley
T11030	15059-15061	FW	denotes	et
T11031	15062-15065	FW	denotes	al.
T11032	15066-15070	CD	denotes	1996
T11033	15070-15071	:	denotes	;
T11034	15072-15077	NNP	denotes	Vogel
T11035	15078-15080	FW	denotes	et
T11036	15081-15084	FW	denotes	al.
T11037	15085-15089	CD	denotes	1996
T11038	15089-15090	:	denotes	;
T11039	15091-15098	NNP	denotes	Altabef
T11040	15099-15101	FW	denotes	et
T11041	15102-15105	FW	denotes	al.
T11042	15106-15110	CD	denotes	1997
T11043	15110-15112	,	denotes	,
T11044	15112-15116	CD	denotes	2000
T11045	15116-15117	-RRB-	denotes	)
T11046	15117-15118	.	denotes	.
T11047	15118-15302	sentence	denotes	Our model predicts that ectopic expression of Tbx15 in ventral mesenchyme should give rise to a dorsalized pigmentation phenotype and could be tested with gain-of-function approaches.
T11048	15119-15122	PRP$	denotes	Our
T11049	15123-15128	NN	denotes	model
T11050	15129-15137	VBZ	denotes	predicts
T11051	15138-15142	IN	denotes	that
T11052	15200-15204	VB	denotes	give
T11053	15143-15150	JJ	denotes	ectopic
T11054	15151-15161	NN	denotes	expression
T11055	15162-15164	IN	denotes	of
T11056	15165-15170	NN	denotes	Tbx15
T11057	15171-15173	IN	denotes	in
T11058	15174-15181	JJ	denotes	ventral
T11059	15182-15192	NN	denotes	mesenchyme
T11060	15193-15199	MD	denotes	should
T11061	15205-15209	NN	denotes	rise
T11062	15210-15212	IN	denotes	to
T11063	15213-15214	DT	denotes	a
T11064	15239-15248	NN	denotes	phenotype
T11065	15215-15225	JJ	denotes	dorsalized
T11066	15226-15238	NN	denotes	pigmentation
T11067	15249-15252	CC	denotes	and
T11068	15253-15258	MD	denotes	could
T11069	15262-15268	VBN	denotes	tested
T11070	15259-15261	VB	denotes	be
T11071	15269-15273	IN	denotes	with
T11072	15274-15278	NN	denotes	gain
T11073	15291-15301	NNS	denotes	approaches
T11074	15278-15279	HYPH	denotes	-
T11075	15279-15281	IN	denotes	of
T11076	15281-15282	HYPH	denotes	-
T11077	15282-15290	NN	denotes	function
T11078	15301-15302	.	denotes	.
T11079	15302-15407	sentence	denotes	However, Tbx15 expression is very dynamic and is restricted to dorsal mesoderm only from E11.5 to E13.5.
T11080	15303-15310	RB	denotes	However
T11081	15329-15331	VBZ	denotes	is
T11082	15310-15312	,	denotes	,
T11083	15312-15317	NN	denotes	Tbx15
T11084	15318-15328	NN	denotes	expression
T11085	15332-15336	RB	denotes	very
T11086	15337-15344	JJ	denotes	dynamic
T11087	15345-15348	CC	denotes	and
T11088	15349-15351	VBZ	denotes	is
T11089	15352-15362	VBN	denotes	restricted
T11090	15363-15365	IN	denotes	to
T11091	15366-15372	JJ	denotes	dorsal
T11092	15373-15381	NN	denotes	mesoderm
T11093	15382-15386	RB	denotes	only
T11094	15387-15391	IN	denotes	from
T11095	15392-15397	NN	denotes	E11.5
T11096	15398-15400	IN	denotes	to
T11097	15401-15406	NN	denotes	E13.5
T11098	15406-15407	.	denotes	.
T11099	15407-15671	sentence	denotes	It is possible that Tbx15 influences skin patterning in a very narrow window of development; alternatively, establishment of dorsal identity by Tbx15 may require another as-yet-unidentified factor that is only present in the mesenchyme underlying dorsal ectoderm.
T11100	15408-15410	PRP	denotes	It
T11101	15411-15413	VBZ	denotes	is
T11102	15562-15569	VB	denotes	require
T11103	15414-15422	JJ	denotes	possible
T11104	15423-15427	IN	denotes	that
T11105	15434-15444	VBZ	denotes	influences
T11106	15428-15433	NN	denotes	Tbx15
T11107	15445-15449	NN	denotes	skin
T11108	15450-15460	NN	denotes	patterning
T11109	15461-15463	IN	denotes	in
T11110	15464-15465	DT	denotes	a
T11111	15478-15484	NN	denotes	window
T11112	15466-15470	RB	denotes	very
T11113	15471-15477	JJ	denotes	narrow
T11114	15485-15487	IN	denotes	of
T11115	15488-15499	NN	denotes	development
T11116	15499-15500	:	denotes	;
T11117	15501-15514	RB	denotes	alternatively
T11118	15514-15516	,	denotes	,
T11119	15516-15529	NN	denotes	establishment
T11120	15530-15532	IN	denotes	of
T11121	15533-15539	JJ	denotes	dorsal
T11122	15540-15548	NN	denotes	identity
T11123	15549-15551	IN	denotes	by
T11124	15552-15557	NN	denotes	Tbx15
T11125	15558-15561	MD	denotes	may
T11126	15570-15577	DT	denotes	another
T11127	15598-15604	NN	denotes	factor
T11128	15578-15580	RB	denotes	as
T11129	15581-15584	RB	denotes	yet
T11130	15580-15581	HYPH	denotes	-
T11131	15585-15597	JJ	denotes	unidentified
T11132	15584-15585	HYPH	denotes	-
T11133	15605-15609	WDT	denotes	that
T11134	15610-15612	VBZ	denotes	is
T11135	15613-15617	RB	denotes	only
T11136	15618-15625	JJ	denotes	present
T11137	15626-15628	IN	denotes	in
T11138	15629-15632	DT	denotes	the
T11139	15633-15643	NN	denotes	mesenchyme
T11140	15644-15654	VBG	denotes	underlying
T11141	15655-15661	JJ	denotes	dorsal
T11142	15662-15670	NN	denotes	ectoderm
T11143	15670-15671	.	denotes	.
T11305	15673-15685	NN	denotes	Pigmentation
T11306	15686-15694	NNS	denotes	Patterns
T11307	15695-15698	CC	denotes	and
T11308	15699-15704	NN	denotes	Tbx15
T11309	15705-15707	IN	denotes	in
T11310	15708-15713	JJ	denotes	Other
T11311	15714-15721	NNS	denotes	Mammals
T11312	15721-16094	sentence	denotes	The lateral somitic frontier, defined as the lineage boundary between somite-derived versus lateral plate-derived mesoderm, is established during somitogenesis early in development (Mauger 1972; Christ et al. 1983; Olivera-Martinez et al. 2000; Nowicki et al. 2003), but remains distinct in postnatal animals despite the potential for extensive cell mixing (see Figure 8).
T11313	15722-15725	DT	denotes	The
T11314	15742-15750	NN	denotes	frontier
T11315	15726-15733	JJ	denotes	lateral
T11316	15734-15741	JJ	denotes	somitic
T11317	15849-15860	VBN	denotes	established
T11318	15750-15752	,	denotes	,
T11319	15752-15759	VBN	denotes	defined
T11320	15760-15762	IN	denotes	as
T11321	15763-15766	DT	denotes	the
T11322	15775-15783	NN	denotes	boundary
T11323	15767-15774	NN	denotes	lineage
T11324	15784-15791	IN	denotes	between
T11325	15792-15798	NN	denotes	somite
T11326	15799-15806	VBN	denotes	derived
T11327	15798-15799	HYPH	denotes	-
T11328	15836-15844	NN	denotes	mesoderm
T11329	15807-15813	CC	denotes	versus
T11330	15814-15821	JJ	denotes	lateral
T11331	15822-15827	NN	denotes	plate
T11332	15828-15835	VBN	denotes	derived
T11333	15827-15828	HYPH	denotes	-
T11334	15844-15846	,	denotes	,
T11335	15846-15848	VBZ	denotes	is
T11336	15861-15867	IN	denotes	during
T11337	15868-15881	NN	denotes	somitogenesis
T11338	15882-15887	RB	denotes	early
T11339	15888-15890	IN	denotes	in
T11340	15891-15902	NN	denotes	development
T11341	15903-15904	-LRB-	denotes	(
T11342	15904-15910	NNP	denotes	Mauger
T11343	15911-15915	CD	denotes	1972
T11344	15915-15916	:	denotes	;
T11345	15917-15923	NNP	denotes	Christ
T11346	15924-15926	FW	denotes	et
T11347	15927-15930	FW	denotes	al.
T11348	15931-15935	CD	denotes	1983
T11349	15935-15936	:	denotes	;
T11350	15937-15944	NNP	denotes	Olivera
T11351	15944-15945	HYPH	denotes	-
T11352	15945-15953	NNP	denotes	Martinez
T11353	15954-15956	FW	denotes	et
T11354	15957-15960	FW	denotes	al.
T11355	15961-15965	CD	denotes	2000
T11356	15965-15966	:	denotes	;
T11357	15967-15974	NNP	denotes	Nowicki
T11358	15975-15977	FW	denotes	et
T11359	15978-15981	FW	denotes	al.
T11360	15982-15986	CD	denotes	2003
T11361	15986-15987	-RRB-	denotes	)
T11362	15987-15989	,	denotes	,
T11363	15989-15992	CC	denotes	but
T11364	15993-16000	VBZ	denotes	remains
T11365	16001-16009	JJ	denotes	distinct
T11366	16010-16012	IN	denotes	in
T11367	16013-16022	JJ	denotes	postnatal
T11368	16023-16030	NNS	denotes	animals
T11369	16031-16038	IN	denotes	despite
T11370	16039-16042	DT	denotes	the
T11371	16043-16052	NN	denotes	potential
T11372	16053-16056	IN	denotes	for
T11373	16057-16066	JJ	denotes	extensive
T11374	16072-16078	NN	denotes	mixing
T11375	16067-16071	NN	denotes	cell
T11376	16079-16080	-LRB-	denotes	(
T11377	16080-16083	VB	denotes	see
T11378	16084-16090	NN	denotes	Figure
T11379	16091-16092	CD	denotes	8
T11380	16092-16093	-RRB-	denotes	)
T11381	16093-16094	.	denotes	.
T11382	16094-16306	sentence	denotes	However, our transplantation and fate-mapping studies demonstrate that the lateral somitic frontier lies dorsal to the pigmentation boundary and does not obviously correlate with a difference in skin morphology.
T11383	16095-16102	RB	denotes	However
T11384	16149-16160	VBP	denotes	demonstrate
T11385	16102-16104	,	denotes	,
T11386	16104-16107	PRP$	denotes	our
T11387	16141-16148	NNS	denotes	studies
T11388	16108-16123	NN	denotes	transplantation
T11389	16124-16127	CC	denotes	and
T11390	16128-16132	NN	denotes	fate
T11391	16132-16133	HYPH	denotes	-
T11392	16133-16140	VBG	denotes	mapping
T11393	16161-16165	IN	denotes	that
T11394	16195-16199	VBZ	denotes	lies
T11395	16166-16169	DT	denotes	the
T11396	16186-16194	NN	denotes	frontier
T11397	16170-16177	JJ	denotes	lateral
T11398	16178-16185	JJ	denotes	somitic
T11399	16200-16206	RB	denotes	dorsal
T11400	16207-16209	IN	denotes	to
T11401	16210-16213	DT	denotes	the
T11402	16227-16235	NN	denotes	boundary
T11403	16214-16226	NN	denotes	pigmentation
T11404	16236-16239	CC	denotes	and
T11405	16240-16244	VBZ	denotes	does
T11406	16259-16268	VB	denotes	correlate
T11407	16245-16248	RB	denotes	not
T11408	16249-16258	RB	denotes	obviously
T11409	16269-16273	IN	denotes	with
T11410	16274-16275	DT	denotes	a
T11411	16276-16286	NN	denotes	difference
T11412	16287-16289	IN	denotes	in
T11413	16290-16294	NN	denotes	skin
T11414	16295-16305	NN	denotes	morphology
T11415	16305-16306	.	denotes	.
T11416	16306-16576	sentence	denotes	An additional dorsoventral domain that is not externally apparent has emerged from studies of Msx1, whose expression marks a subgroup of somite-derived mesenchymal cells that contribute to dermis in a narrow stripe along the paraspinal region (Houzelstein et al. 2000).
T11417	16307-16309	DT	denotes	An
T11418	16334-16340	NN	denotes	domain
T11419	16310-16320	JJ	denotes	additional
T11420	16321-16333	JJ	denotes	dorsoventral
T11421	16377-16384	VBN	denotes	emerged
T11422	16341-16345	WDT	denotes	that
T11423	16346-16348	VBZ	denotes	is
T11424	16349-16352	RB	denotes	not
T11425	16353-16363	RB	denotes	externally
T11426	16364-16372	JJ	denotes	apparent
T11427	16373-16376	VBZ	denotes	has
T11428	16385-16389	IN	denotes	from
T11429	16390-16397	NNS	denotes	studies
T11430	16398-16400	IN	denotes	of
T11431	16401-16405	NN	denotes	Msx1
T11432	16405-16407	,	denotes	,
T11433	16407-16412	WP$	denotes	whose
T11434	16413-16423	NN	denotes	expression
T11435	16424-16429	VBZ	denotes	marks
T11436	16430-16431	DT	denotes	a
T11437	16432-16440	NN	denotes	subgroup
T11438	16441-16443	IN	denotes	of
T11439	16444-16450	NN	denotes	somite
T11440	16451-16458	VBN	denotes	derived
T11441	16450-16451	HYPH	denotes	-
T11442	16471-16476	NNS	denotes	cells
T11443	16459-16470	JJ	denotes	mesenchymal
T11444	16477-16481	WDT	denotes	that
T11445	16482-16492	VBP	denotes	contribute
T11446	16493-16495	IN	denotes	to
T11447	16496-16502	NN	denotes	dermis
T11448	16503-16505	IN	denotes	in
T11449	16506-16507	DT	denotes	a
T11450	16515-16521	NN	denotes	stripe
T11451	16508-16514	JJ	denotes	narrow
T11452	16522-16527	IN	denotes	along
T11453	16528-16531	DT	denotes	the
T11454	16543-16549	NN	denotes	region
T11455	16532-16542	JJ	denotes	paraspinal
T11456	16550-16551	-LRB-	denotes	(
T11457	16551-16562	NNP	denotes	Houzelstein
T11458	16563-16565	FW	denotes	et
T11459	16566-16569	FW	denotes	al.
T11460	16570-16574	CD	denotes	2000
T11461	16574-16575	-RRB-	denotes	)
T11462	16575-16576	.	denotes	.
T11463	16576-16815	sentence	denotes	Thus, there exist at least three distinct boundaries in postnatal mammalian skin that are parallel to the sagittal plane, marked by differences in pigment-type synthesis, differences in cell lineage, and differences in expression of Msx1.
T11464	16577-16581	RB	denotes	Thus
T11465	16589-16594	VBP	denotes	exist
T11466	16581-16583	,	denotes	,
T11467	16583-16588	EX	denotes	there
T11468	16595-16597	RB	denotes	at
T11469	16604-16609	CD	denotes	three
T11470	16598-16603	RBS	denotes	least
T11471	16619-16629	NNS	denotes	boundaries
T11472	16610-16618	JJ	denotes	distinct
T11473	16630-16632	IN	denotes	in
T11474	16633-16642	JJ	denotes	postnatal
T11475	16653-16657	NN	denotes	skin
T11476	16643-16652	JJ	denotes	mammalian
T11477	16658-16662	WDT	denotes	that
T11478	16663-16666	VBP	denotes	are
T11479	16667-16675	JJ	denotes	parallel
T11480	16676-16678	IN	denotes	to
T11481	16679-16682	DT	denotes	the
T11482	16692-16697	NN	denotes	plane
T11483	16683-16691	JJ	denotes	sagittal
T11484	16697-16699	,	denotes	,
T11485	16699-16705	VBN	denotes	marked
T11486	16706-16708	IN	denotes	by
T11487	16709-16720	NNS	denotes	differences
T11488	16721-16723	IN	denotes	in
T11489	16724-16731	NN	denotes	pigment
T11490	16732-16736	NN	denotes	type
T11491	16731-16732	HYPH	denotes	-
T11492	16737-16746	NN	denotes	synthesis
T11493	16746-16748	,	denotes	,
T11494	16748-16759	NNS	denotes	differences
T11495	16760-16762	IN	denotes	in
T11496	16763-16767	NN	denotes	cell
T11497	16768-16775	NN	denotes	lineage
T11498	16775-16777	,	denotes	,
T11499	16777-16780	CC	denotes	and
T11500	16781-16792	NNS	denotes	differences
T11501	16793-16795	IN	denotes	in
T11502	16796-16806	NN	denotes	expression
T11503	16807-16809	IN	denotes	of
T11504	16810-16814	NN	denotes	Msx1
T11505	16814-16815	.	denotes	.
T11506	16815-17003	sentence	denotes	In rodents, only the pigmentation boundary is evident externally, but many mammals have more complicated patterns of hair type, length, and/or color that vary along the dorsoventral axis.
T11507	16816-16818	IN	denotes	In
T11508	16859-16861	VBZ	denotes	is
T11509	16819-16826	NNS	denotes	rodents
T11510	16826-16828	,	denotes	,
T11511	16828-16832	RB	denotes	only
T11512	16850-16858	NN	denotes	boundary
T11513	16833-16836	DT	denotes	the
T11514	16837-16849	NN	denotes	pigmentation
T11515	16862-16869	JJ	denotes	evident
T11516	16870-16880	RB	denotes	externally
T11517	16880-16882	,	denotes	,
T11518	16882-16885	CC	denotes	but
T11519	16886-16890	JJ	denotes	many
T11520	16891-16898	NNS	denotes	mammals
T11521	16899-16903	VBP	denotes	have
T11522	16904-16908	RBR	denotes	more
T11523	16909-16920	JJ	denotes	complicated
T11524	16921-16929	NNS	denotes	patterns
T11525	16930-16932	IN	denotes	of
T11526	16933-16937	NN	denotes	hair
T11527	16938-16942	NN	denotes	type
T11528	16942-16944	,	denotes	,
T11529	16944-16950	NN	denotes	length
T11530	16950-16952	,	denotes	,
T11531	16952-16955	CC	denotes	and
T11532	16955-16956	HYPH	denotes	/
T11533	16956-16958	CC	denotes	or
T11534	16959-16964	NN	denotes	color
T11535	16965-16969	WDT	denotes	that
T11536	16970-16974	VBP	denotes	vary
T11537	16975-16980	IN	denotes	along
T11538	16981-16984	DT	denotes	the
T11539	16998-17002	NN	denotes	axis
T11540	16985-16997	JJ	denotes	dorsoventral
T11541	17002-17003	.	denotes	.
T11542	17003-17267	sentence	denotes	Raccoons, squirrels, skunks, and many different ungulates exhibit lateral stripes whose developmental origins have not been investigated, but may correspond to the lateral somitic frontier, the paraspinal Msx1 compartment, or an interaction between these domains.
T11543	17004-17012	NNS	denotes	Raccoons
T11544	17062-17069	VBP	denotes	exhibit
T11545	17012-17014	,	denotes	,
T11546	17014-17023	NNS	denotes	squirrels
T11547	17023-17025	,	denotes	,
T11548	17025-17031	NNS	denotes	skunks
T11549	17031-17033	,	denotes	,
T11550	17033-17036	CC	denotes	and
T11551	17037-17041	JJ	denotes	many
T11552	17052-17061	NNS	denotes	ungulates
T11553	17042-17051	JJ	denotes	different
T11554	17070-17077	JJ	denotes	lateral
T11555	17078-17085	NNS	denotes	stripes
T11556	17086-17091	WP$	denotes	whose
T11557	17106-17113	NNS	denotes	origins
T11558	17092-17105	JJ	denotes	developmental
T11559	17128-17140	VBN	denotes	investigated
T11560	17114-17118	VBP	denotes	have
T11561	17119-17122	RB	denotes	not
T11562	17123-17127	VBN	denotes	been
T11563	17140-17142	,	denotes	,
T11564	17142-17145	CC	denotes	but
T11565	17146-17149	MD	denotes	may
T11566	17150-17160	VB	denotes	correspond
T11567	17161-17163	IN	denotes	to
T11568	17164-17167	DT	denotes	the
T11569	17184-17192	NN	denotes	frontier
T11570	17168-17175	JJ	denotes	lateral
T11571	17176-17183	JJ	denotes	somitic
T11572	17192-17194	,	denotes	,
T11573	17194-17197	DT	denotes	the
T11574	17214-17225	NN	denotes	compartment
T11575	17198-17208	JJ	denotes	paraspinal
T11576	17209-17213	NN	denotes	Msx1
T11577	17225-17227	,	denotes	,
T11578	17227-17229	CC	denotes	or
T11579	17230-17232	DT	denotes	an
T11580	17233-17244	NN	denotes	interaction
T11581	17245-17252	IN	denotes	between
T11582	17253-17258	DT	denotes	these
T11583	17259-17266	NNS	denotes	domains
T11584	17266-17267	.	denotes	.
T11585	17267-17419	sentence	denotes	The effect of Tbx15 on pigmentation in laboratory mice is reminiscent of coat-color patterns in both selected and natural populations of other mammals.
T11586	17268-17271	DT	denotes	The
T11587	17272-17278	NN	denotes	effect
T11588	17323-17325	VBZ	denotes	is
T11589	17279-17281	IN	denotes	of
T11590	17282-17287	NN	denotes	Tbx15
T11591	17288-17290	IN	denotes	on
T11592	17291-17303	NN	denotes	pigmentation
T11593	17304-17306	IN	denotes	in
T11594	17307-17317	NN	denotes	laboratory
T11595	17318-17322	NNS	denotes	mice
T11596	17326-17337	JJ	denotes	reminiscent
T11597	17338-17340	IN	denotes	of
T11598	17341-17345	NN	denotes	coat
T11599	17346-17351	NN	denotes	color
T11600	17345-17346	HYPH	denotes	-
T11601	17352-17360	NNS	denotes	patterns
T11602	17361-17363	IN	denotes	in
T11603	17364-17368	CC	denotes	both
T11604	17369-17377	JJ	denotes	selected
T11605	17390-17401	NNS	denotes	populations
T11606	17378-17381	CC	denotes	and
T11607	17382-17389	JJ	denotes	natural
T11608	17402-17404	IN	denotes	of
T11609	17405-17410	JJ	denotes	other
T11610	17411-17418	NNS	denotes	mammals
T11611	17418-17419	.	denotes	.
T11612	17419-17723	sentence	denotes	Saddle markings are common in some dog breeds, such as German shepherds, and in certain populations of Peromyscus polionotus, in which a dorsal extension of ventral depigmentation provides an adaptive advantage to subspecies that live on white sand reefs (Blair 1951; Kaufman 1974; Belk and Smith 1996).
T11613	17420-17426	NN	denotes	Saddle
T11614	17427-17435	NNS	denotes	markings
T11615	17436-17439	VBP	denotes	are
T11616	17440-17446	JJ	denotes	common
T11617	17447-17449	IN	denotes	in
T11618	17450-17454	DT	denotes	some
T11619	17459-17465	NNS	denotes	breeds
T11620	17455-17458	NN	denotes	dog
T11621	17465-17467	,	denotes	,
T11622	17467-17471	JJ	denotes	such
T11623	17472-17474	IN	denotes	as
T11624	17475-17481	NNP	denotes	German
T11625	17482-17491	NNS	denotes	shepherds
T11626	17491-17493	,	denotes	,
T11627	17493-17496	CC	denotes	and
T11628	17497-17499	IN	denotes	in
T11629	17500-17507	JJ	denotes	certain
T11630	17508-17519	NNS	denotes	populations
T11631	17520-17522	IN	denotes	of
T11632	17523-17533	NNP	denotes	Peromyscus
T11633	17534-17544	NNP	denotes	polionotus
T11634	17544-17546	,	denotes	,
T11635	17546-17548	IN	denotes	in
T11636	17600-17608	VBZ	denotes	provides
T11637	17549-17554	WDT	denotes	which
T11638	17555-17556	DT	denotes	a
T11639	17564-17573	NN	denotes	extension
T11640	17557-17563	JJ	denotes	dorsal
T11641	17574-17576	IN	denotes	of
T11642	17577-17584	JJ	denotes	ventral
T11643	17585-17599	NN	denotes	depigmentation
T11644	17609-17611	DT	denotes	an
T11645	17621-17630	NN	denotes	advantage
T11646	17612-17620	JJ	denotes	adaptive
T11647	17631-17633	IN	denotes	to
T11648	17634-17644	NNS	denotes	subspecies
T11649	17645-17649	WDT	denotes	that
T11650	17650-17654	VBP	denotes	live
T11651	17655-17657	IN	denotes	on
T11652	17658-17663	JJ	denotes	white
T11653	17669-17674	NNS	denotes	reefs
T11654	17664-17668	NN	denotes	sand
T11655	17675-17676	-LRB-	denotes	(
T11656	17676-17681	NNP	denotes	Blair
T11657	17682-17686	CD	denotes	1951
T11658	17686-17687	:	denotes	;
T11659	17688-17695	NNP	denotes	Kaufman
T11660	17696-17700	CD	denotes	1974
T11661	17700-17701	:	denotes	;
T11662	17702-17706	NNP	denotes	Belk
T11663	17707-17710	CC	denotes	and
T11664	17711-17716	NNP	denotes	Smith
T11665	17717-17721	CD	denotes	1996
T11666	17721-17722	-RRB-	denotes	)
T11667	17722-17723	.	denotes	.
T11668	17723-17947	sentence	denotes	Neither German shepherds nor deer mice have craniofacial characteristics similar to the deH mutation, but the pigmentation patterns in these animals could represent alterations in the regulation or action of Tbx15 activity.
T11669	17724-17731	CC	denotes	Neither
T11670	17739-17748	NNS	denotes	shepherds
T11671	17732-17738	NNP	denotes	German
T11672	17763-17767	VBP	denotes	have
T11673	17749-17752	CC	denotes	nor
T11674	17753-17757	NN	denotes	deer
T11675	17758-17762	NNS	denotes	mice
T11676	17768-17780	JJ	denotes	craniofacial
T11677	17781-17796	NNS	denotes	characteristics
T11678	17797-17804	JJ	denotes	similar
T11679	17805-17807	IN	denotes	to
T11680	17808-17811	DT	denotes	the
T11681	17816-17824	NN	denotes	mutation
T11682	17812-17815	NN	denotes	deH
T11683	17824-17826	,	denotes	,
T11684	17826-17829	CC	denotes	but
T11685	17830-17833	DT	denotes	the
T11686	17847-17855	NNS	denotes	patterns
T11687	17834-17846	NN	denotes	pigmentation
T11688	17879-17888	VB	denotes	represent
T11689	17856-17858	IN	denotes	in
T11690	17859-17864	DT	denotes	these
T11691	17865-17872	NNS	denotes	animals
T11692	17873-17878	MD	denotes	could
T11693	17889-17900	NNS	denotes	alterations
T11694	17901-17903	IN	denotes	in
T11695	17904-17907	DT	denotes	the
T11696	17908-17918	NN	denotes	regulation
T11697	17919-17921	CC	denotes	or
T11698	17922-17928	NN	denotes	action
T11699	17929-17931	IN	denotes	of
T11700	17932-17937	NN	denotes	Tbx15
T11701	17938-17946	NN	denotes	activity
T11702	17946-17947	.	denotes	.
T11703	17947-18149	sentence	denotes	From the opposite perspective, the effects of Tbx15 on coat color are only apparent in certain genetic backgrounds and may not be evident at all in mammals that lack dorsoventral pigmentation patterns.
T11704	17948-17952	IN	denotes	From
T11705	18014-18017	VBP	denotes	are
T11706	17953-17956	DT	denotes	the
T11707	17966-17977	NN	denotes	perspective
T11708	17957-17965	JJ	denotes	opposite
T11709	17977-17979	,	denotes	,
T11710	17979-17982	DT	denotes	the
T11711	17983-17990	NNS	denotes	effects
T11712	17991-17993	IN	denotes	of
T11713	17994-17999	NN	denotes	Tbx15
T11714	18000-18002	IN	denotes	on
T11715	18003-18007	NN	denotes	coat
T11716	18008-18013	NN	denotes	color
T11717	18018-18022	RB	denotes	only
T11718	18023-18031	JJ	denotes	apparent
T11719	18032-18034	IN	denotes	in
T11720	18035-18042	JJ	denotes	certain
T11721	18051-18062	NNS	denotes	backgrounds
T11722	18043-18050	JJ	denotes	genetic
T11723	18063-18066	CC	denotes	and
T11724	18067-18070	MD	denotes	may
T11725	18075-18077	VB	denotes	be
T11726	18071-18074	RB	denotes	not
T11727	18078-18085	JJ	denotes	evident
T11728	18086-18088	RB	denotes	at
T11729	18089-18092	RB	denotes	all
T11730	18093-18095	IN	denotes	in
T11731	18096-18103	NNS	denotes	mammals
T11732	18104-18108	WDT	denotes	that
T11733	18109-18113	VBP	denotes	lack
T11734	18114-18126	JJ	denotes	dorsoventral
T11735	18140-18148	NNS	denotes	patterns
T11736	18127-18139	NN	denotes	pigmentation
T11737	18148-18149	.	denotes	.
T11738	18149-18320	sentence	denotes	Studying the sequence and expression of Tbx15 in other vertebrates may provide additional insight into patterns that affect the skeleton as well as the pigmentary system.
T11739	18150-18158	VBG	denotes	Studying
T11740	18221-18228	VB	denotes	provide
T11741	18159-18162	DT	denotes	the
T11742	18163-18171	NN	denotes	sequence
T11743	18172-18175	CC	denotes	and
T11744	18176-18186	NN	denotes	expression
T11745	18187-18189	IN	denotes	of
T11746	18190-18195	NN	denotes	Tbx15
T11747	18196-18198	IN	denotes	in
T11748	18199-18204	JJ	denotes	other
T11749	18205-18216	NNS	denotes	vertebrates
T11750	18217-18220	MD	denotes	may
T11751	18229-18239	JJ	denotes	additional
T11752	18240-18247	NN	denotes	insight
T11753	18248-18252	IN	denotes	into
T11754	18253-18261	NNS	denotes	patterns
T11755	18262-18266	WDT	denotes	that
T11756	18267-18273	VBP	denotes	affect
T11757	18274-18277	DT	denotes	the
T11758	18278-18286	NN	denotes	skeleton
T11759	18287-18289	RB	denotes	as
T11760	18295-18297	IN	denotes	as
T11761	18290-18294	RB	denotes	well
T11762	18298-18301	DT	denotes	the
T11763	18313-18319	NN	denotes	system
T11764	18302-18312	JJ	denotes	pigmentary
T11765	18319-18320	.	denotes	.
R5210	T7563	T7564	amod	Several,mutations
R5211	T7564	T7565	nsubjpass	mutations,identified
R5212	T7566	T7564	cc	and,mutations
R5213	T7567	T7564	conj	genes,mutations
R5214	T7568	T7565	aux	have,identified
R5215	T7569	T7565	auxpass	been,identified
R5216	T7570	T7571	dep	that,affect
R5217	T7571	T7565	ccomp	affect,identified
R5218	T7572	T7573	det	the,pattern
R5219	T7573	T7571	dobj	pattern,affect
R5220	T7574	T7573	prep	of,pattern
R5221	T7575	T7576	compound	hair,follicle
R5222	T7576	T7577	compound	follicle,development
R5223	T7577	T7574	pobj	development,of
R5224	T7578	T7565	punct	", ",identified
R5225	T7579	T7565	cc	but,identified
R5226	T7580	T7581	nsubj	Tbx15,is
R5227	T7581	T7565	conj	is,identified
R5228	T7582	T7583	det	the,gene
R5229	T7583	T7581	attr	gene,is
R5230	T7584	T7583	amod	only,gene
R5231	T7585	T7586	prep	of,are
R5232	T7586	T7583	relcl	are,gene
R5233	T7587	T7585	pobj	which,of
R5234	T7588	T7586	nsubj	we,are
R5235	T7589	T7586	acomp	aware,are
R5236	T7590	T7591	dep	that,affects
R5237	T7591	T7583	relcl	affects,gene
R5238	T7592	T7593	det	the,pattern
R5239	T7593	T7591	dobj	pattern,affects
R5240	T7594	T7593	prep	of,pattern
R5241	T7595	T7596	compound	hair,pigmentation
R5242	T7596	T7594	pobj	pigmentation,of
R5243	T7597	T7591	prep	in,affects
R5244	T7598	T7599	amod	different,regions
R5245	T7599	T7597	pobj	regions,in
R5246	T7600	T7599	compound	body,regions
R5247	T7601	T7581	punct	.,is
R5248	T7603	T7604	amod	Ventral,areas
R5249	T7604	T7605	nsubjpass	areas,expanded
R5250	T7606	T7607	dep	that,produce
R5251	T7607	T7604	relcl	produce,areas
R5252	T7608	T7607	advmod	normally,produce
R5253	T7609	T7610	amod	yellow,hair
R5254	T7610	T7607	dobj	hair,produce
R5255	T7611	T7607	prep	in,produce
R5256	T7612	T7613	det	the,trunk
R5257	T7613	T7611	pobj	trunk,in
R5258	T7614	T7613	punct	", ",trunk
R5259	T7615	T7613	conj	limbs,trunk
R5260	T7616	T7615	punct	", ",limbs
R5261	T7617	T7615	cc	and,limbs
R5262	T7618	T7619	amod	craniofacial,regions
R5263	T7619	T7615	conj	regions,limbs
R5264	T7620	T7605	auxpass	are,expanded
R5265	T7621	T7605	prep	in,expanded
R5266	T7622	T7623	nmod	deH,deH
R5267	T7623	T7625	compound	deH,mice
R5268	T7624	T7623	punct	/,deH
R5269	T7625	T7621	pobj	mice,in
R5270	T7626	T7605	cc	and,expanded
R5271	T7627	T7605	punct	", ",expanded
R5272	T7628	T7629	prep	in,represent
R5273	T7629	T7605	conj	represent,expanded
R5274	T7630	T7631	det	the,trunk
R5275	T7631	T7628	pobj	trunk,in
R5276	T7632	T7633	advmod	at,least
R5277	T7633	T7629	advmod	least,represent
R5278	T7634	T7629	punct	", ",represent
R5279	T7635	T7636	amod	inappropriate,expression
R5280	T7636	T7629	dobj	expression,represent
R5281	T7637	T7636	amod	dorsal,expression
R5282	T7638	T7636	prep	of,expression
R5283	T7639	T7640	det	an,isoform
R5284	T7640	T7638	pobj	isoform,of
R5285	T7641	T7640	compound	Agouti,isoform
R5286	T7642	T7640	compound	mRNA,isoform
R5287	T7643	T7644	dep	that,restricted
R5288	T7644	T7640	relcl	restricted,isoform
R5289	T7645	T7644	auxpass	is,restricted
R5290	T7646	T7644	advmod	normally,restricted
R5291	T7647	T7644	prep	to,restricted
R5292	T7648	T7649	amod	ventral,skin
R5293	T7649	T7647	pobj	skin,to
R5294	T7650	T7605	punct	.,expanded
R5295	T7652	T7653	det	The,allele
R5296	T7653	T7655	nsubjpass	allele,caused
R5297	T7654	T7653	compound	deH,allele
R5298	T7656	T7655	auxpass	is,caused
R5299	T7657	T7655	agent	by,caused
R5300	T7658	T7659	det	a,deletion
R5301	T7659	T7657	pobj	deletion,by
R5302	T7660	T7659	amod	large,deletion
R5303	T7661	T7662	dep	that,removes
R5304	T7662	T7659	relcl	removes,deletion
R5305	T7663	T7662	dobj	most,removes
R5306	T7664	T7663	prep	of,most
R5307	T7665	T7666	det	the,sequence
R5308	T7666	T7664	pobj	sequence,of
R5309	T7667	T7666	compound	Tbx15,sequence
R5310	T7668	T7666	compound	coding,sequence
R5311	T7669	T7655	punct	", ",caused
R5312	T7670	T7655	cc	but,caused
R5313	T7671	T7672	det	the,phenotype
R5314	T7672	T7674	nsubjpass	phenotype,caused
R5315	T7673	T7672	amod	pleiotropic,phenotype
R5316	T7674	T7655	conj	caused,caused
R5317	T7675	T7674	auxpass	is,caused
R5318	T7676	T7674	agent	by,caused
R5319	T7677	T7678	det	a,loss
R5320	T7678	T7676	pobj	loss,by
R5321	T7679	T7678	amod	simple,loss
R5322	T7680	T7678	prep	of,loss
R5323	T7681	T7680	pobj	function,of
R5324	T7682	T7678	prep	for,loss
R5325	T7683	T7682	pobj	Tbx15,for
R5326	T7684	T7685	advmod	rather,than
R5327	T7685	T7678	cc	than,loss
R5328	T7686	T7687	det	a,effect
R5329	T7687	T7678	conj	effect,loss
R5330	T7688	T7689	amod	dominant,negative
R5331	T7689	T7687	amod	negative,effect
R5332	T7690	T7689	punct	-,negative
R5333	T7691	T7689	cc	or,negative
R5334	T7692	T7689	conj	contiguous,negative
R5335	T7693	T7687	compound	gene,effect
R5336	T7694	T7674	punct	.,caused
R5337	T7696	T7697	prep	In,is
R5338	T7698	T7696	amod	particular,In
R5339	T7699	T7697	punct	", ",is
R5340	T7700	T7697	expl	there,is
R5341	T7701	T7702	det	no,phenotype
R5342	T7702	T7697	attr	phenotype,is
R5343	T7703	T7702	amod	heterozygous,phenotype
R5344	T7704	T7697	punct	", ",is
R5345	T7705	T7706	det	no,genes
R5346	T7706	T7708	nsubj	genes,lie
R5347	T7707	T7706	amod	other,genes
R5348	T7708	T7697	conj	lie,is
R5349	T7709	T7708	prep	within,lie
R5350	T7710	T7709	cc	or,within
R5351	T7711	T7712	advmod	close,breakpoints
R5352	T7712	T7709	conj	breakpoints,within
R5353	T7713	T7711	prep	to,close
R5354	T7714	T7712	det	the,breakpoints
R5355	T7715	T7712	compound	deletion,breakpoints
R5356	T7716	T7708	punct	", ",lie
R5357	T7717	T7708	cc	and,lie
R5358	T7718	T7719	det	the,pattern
R5359	T7719	T7721	nsubj	pattern,is
R5360	T7720	T7719	compound	expression,pattern
R5361	T7721	T7708	conj	is,lie
R5362	T7722	T7719	prep	of,pattern
R5363	T7723	T7722	pobj	Tbx15,of
R5364	T7724	T7721	acomp	consistent,is
R5365	T7725	T7724	prep	with,consistent
R5366	T7726	T7727	det	the,spectrum
R5367	T7727	T7725	pobj	spectrum,with
R5368	T7728	T7727	prep	of,spectrum
R5369	T7729	T7730	amod	phenotypic,abnormalities
R5370	T7730	T7728	pobj	abnormalities,of
R5371	T7731	T7721	prep	in,is
R5372	T7732	T7733	preconj	both,allele
R5373	T7733	T7731	pobj	allele,in
R5374	T7734	T7733	det	the,allele
R5375	T7735	T7733	amod	original,allele
R5376	T7736	T7733	compound	de,allele
R5377	T7737	T7733	cc	and,allele
R5378	T7738	T7739	det	the,allele
R5379	T7739	T7733	conj	allele,allele
R5380	T7740	T7739	compound	deH,allele
R5381	T7741	T7721	punct	.,is
R5382	T7743	T7744	advmod	Finally,has
R5383	T7745	T7744	punct	", ",has
R5384	T7746	T7747	det	a,allele
R5385	T7747	T7744	nsubj	allele,has
R5386	T7748	T7747	nmod	Tbx15,allele
R5387	T7749	T7747	amod	targeted,allele
R5388	T7750	T7751	det	the,phenotype
R5389	T7751	T7744	dobj	phenotype,has
R5390	T7752	T7751	amod	same,phenotype
R5391	T7753	T7751	prep	as,phenotype
R5392	T7754	T7753	pobj	deH,as
R5393	T7755	T7744	punct	.,has
R5394	T7757	T7758	poss	Our,results
R5395	T7758	T7759	nsubj	results,suggest
R5396	T7760	T7761	mark	that,provides
R5397	T7761	T7759	ccomp	provides,suggest
R5398	T7762	T7763	amod	patterned,expression
R5399	T7763	T7761	nsubj	expression,provides
R5400	T7764	T7763	prep	of,expression
R5401	T7765	T7764	pobj	Tbx15,of
R5402	T7766	T7767	det	an,cue
R5403	T7767	T7761	dobj	cue,provides
R5404	T7768	T7767	amod	instructional,cue
R5405	T7769	T7767	acl	required,cue
R5406	T7770	T7771	aux	to,establish
R5407	T7771	T7769	advcl	establish,required
R5408	T7772	T7773	det	the,identity
R5409	T7773	T7771	dobj	identity,establish
R5410	T7774	T7773	amod	future,identity
R5411	T7775	T7773	prep	of,identity
R5412	T7776	T7777	amod	dorsal,dermis
R5413	T7777	T7775	pobj	dermis,of
R5414	T7778	T7771	prep	with,establish
R5415	T7779	T7778	pobj	regard,with
R5416	T7780	T7779	prep	to,regard
R5417	T7781	T7782	amod	pigmentary,patterning
R5418	T7782	T7780	pobj	patterning,to
R5419	T7783	T7781	cc	and,pigmentary
R5420	T7784	T7785	compound	hair,length
R5421	T7785	T7781	conj	length,pigmentary
R5422	T7786	T7759	punct	.,suggest
R5423	T7788	T7789	det	The,edge
R5424	T7789	T7791	nsubj	edge,correspond
R5425	T7790	T7789	amod	ventral,edge
R5426	T7792	T7789	prep	of,edge
R5427	T7793	T7794	compound	Tbx15,expression
R5428	T7794	T7792	pobj	expression,of
R5429	T7795	T7789	prep	in,edge
R5430	T7796	T7797	det	the,flank
R5431	T7797	T7795	pobj	flank,in
R5432	T7798	T7797	amod	developing,flank
R5433	T7799	T7791	aux	does,correspond
R5434	T7800	T7791	neg	not,correspond
R5435	T7801	T7791	prep	to,correspond
R5436	T7802	T7803	det	a,compartment
R5437	T7803	T7801	pobj	compartment,to
R5438	T7804	T7803	amod	known,compartment
R5439	T7805	T7803	compound	lineage,compartment
R5440	T7806	T7791	punct	", ",correspond
R5441	T7807	T7791	cc	but,correspond
R5442	T7808	T7791	punct	", ",correspond
R5443	T7809	T7810	prep	like,occurs
R5444	T7810	T7791	conj	occurs,correspond
R5445	T7811	T7812	compound	limb,development
R5446	T7812	T7809	pobj	development,like
R5447	T7813	T7810	punct	", ",occurs
R5448	T7814	T7810	prep	within,occurs
R5449	T7815	T7816	amod	lateral,plate
R5450	T7816	T7817	compound	plate,mesoderm
R5451	T7817	T7814	pobj	mesoderm,within
R5452	T7818	T7791	punct	.,correspond
R5453	T7820	T7821	det	These,findings
R5454	T7821	T7822	nsubj	findings,represent
R5455	T7823	T7824	det	a,role
R5456	T7824	T7822	dobj	role,represent
R5457	T7825	T7824	amod	novel,role
R5458	T7826	T7824	prep	for,role
R5459	T7827	T7828	compound	T,box
R5460	T7828	T7830	compound	box,action
R5461	T7829	T7828	punct	-,box
R5462	T7830	T7826	pobj	action,for
R5463	T7831	T7830	compound	gene,action
R5464	T7832	T7824	prep	in,role
R5465	T7833	T7834	amod	embryonic,development
R5466	T7834	T7832	pobj	development,in
R5467	T7835	T7822	cc	and,represent
R5468	T7836	T7822	conj	provide,represent
R5469	T7837	T7836	dobj	evidence,provide
R5470	T7838	T7837	prep	for,evidence
R5471	T7839	T7840	det	a,complexity
R5472	T7840	T7838	pobj	complexity,for
R5473	T7841	T7842	advmod	previously,unappreciated
R5474	T7842	T7840	amod	unappreciated,complexity
R5475	T7843	T7840	prep	to,complexity
R5476	T7844	T7843	pobj	acquisition,to
R5477	T7845	T7844	prep	of,acquisition
R5478	T7846	T7847	amod	dorsoventral,identity
R5479	T7847	T7845	pobj	identity,of
R5480	T7848	T7847	amod	positional,identity
R5481	T7849	T7844	prep	in,acquisition
R5482	T7850	T7851	amod	mammalian,skin
R5483	T7851	T7849	pobj	skin,in
R5484	T7852	T7822	punct	.,represent
R5485	T7946	T7947	amod	Distinct,Regions
R5486	T7947	T7949	nsubj	Regions,Represent
R5487	T7948	T7947	amod	Morphologic,Regions
R5488	T7950	T7951	det	the,Sum
R5489	T7951	T7949	dobj	Sum,Represent
R5490	T7952	T7951	prep	of,Sum
R5491	T7953	T7954	amod	Different,Gradients
R5492	T7954	T7952	pobj	Gradients,of
R5493	T7956	T7957	det	The,boundary
R5494	T7957	T7959	nsubj	boundary,is
R5495	T7958	T7957	amod	visual,boundary
R5496	T7960	T7957	prep	between,boundary
R5497	T7961	T7962	amod	dorsal,skin
R5498	T7962	T7960	pobj	skin,between
R5499	T7963	T7961	cc	and,dorsal
R5500	T7964	T7961	conj	ventral,dorsal
R5501	T7965	T7957	prep	in,boundary
R5502	T7966	T7967	nmod	at,at
R5503	T7967	T7969	compound	at,mice
R5504	T7968	T7967	punct	/,at
R5505	T7969	T7965	pobj	mice,in
R5506	T7970	T7959	acomp	reminiscent,is
R5507	T7971	T7970	prep	of,reminiscent
R5508	T7972	T7973	amod	other,systems
R5509	T7973	T7971	pobj	systems,of
R5510	T7974	T7975	prep	in,enforce
R5511	T7975	T7973	relcl	enforce,systems
R5512	T7976	T7974	pobj	which,in
R5513	T7977	T7978	amod	adjacent,compartments
R5514	T7978	T7975	nsubj	compartments,enforce
R5515	T7979	T7980	det	a,choice
R5516	T7980	T7975	dobj	choice,enforce
R5517	T7981	T7980	amod	binary,choice
R5518	T7982	T7980	prep	between,choice
R5519	T7983	T7984	amod	alternative,patterns
R5520	T7984	T7982	pobj	patterns,between
R5521	T7985	T7984	prep	of,patterns
R5522	T7986	T7987	compound	gene,expression
R5523	T7987	T7985	pobj	expression,of
R5524	T7988	T7987	cc	and,expression
R5525	T7989	T7990	compound	cell,fate
R5526	T7990	T7987	conj	fate,expression
R5527	T7991	T7992	punct	(,reviewed
R5528	T7992	T7959	parataxis	reviewed,is
R5529	T7993	T7992	prep	in,reviewed
R5530	T7994	T7993	pobj	Dahmann,in
R5531	T7995	T7994	cc	and,Dahmann
R5532	T7996	T7994	conj	Basler,Dahmann
R5533	T7997	T7994	npadvmod	1999,Dahmann
R5534	T7998	T7992	punct	),reviewed
R5535	T7999	T7959	punct	.,is
R5536	T8001	T8002	advmod	However,distributed
R5537	T8003	T8002	punct	", ",distributed
R5538	T8004	T8005	compound	Agouti,mRNA
R5539	T8005	T8002	nsubjpass	mRNA,distributed
R5540	T8006	T8005	prep	in,mRNA
R5541	T8007	T8008	preconj	both,embryonic
R5542	T8008	T8009	amod	embryonic,skin
R5543	T8009	T8006	pobj	skin,in
R5544	T8010	T8008	cc	and,embryonic
R5545	T8011	T8008	conj	postnatal,embryonic
R5546	T8012	T8002	auxpass	is,distributed
R5547	T8013	T8002	prep	along,distributed
R5548	T8014	T8015	det	a,gradient
R5549	T8015	T8013	pobj	gradient,along
R5550	T8016	T8017	poss	whose,boundary
R5551	T8017	T8019	dep	boundary,is
R5552	T8018	T8017	amod	dorsal,boundary
R5553	T8019	T8015	relcl	is,gradient
R5554	T8020	T8019	acomp	indistinct,is
R5555	T8021	T8019	cc	and,is
R5556	T8022	T8019	conj	overlaps,is
R5557	T8023	T8022	prep	with,overlaps
R5558	T8024	T8025	nummod	two,gradients
R5559	T8025	T8023	pobj	gradients,with
R5560	T8026	T8025	amod	additional,gradients
R5561	T8027	T8025	acl	recognized,gradients
R5562	T8028	T8027	prep	by,recognized
R5563	T8029	T8030	poss	their,effects
R5564	T8030	T8028	pobj	effects,by
R5565	T8031	T8030	prep	on,effects
R5566	T8032	T8033	compound	hair,length
R5567	T8033	T8031	pobj	length,on
R5568	T8034	T8033	cc	and,length
R5569	T8035	T8036	amod	histochemical,staining
R5570	T8036	T8033	conj	staining,length
R5571	T8037	T8002	prep	for,distributed
R5572	T8038	T8037	pobj	melanocytes,for
R5573	T8039	T8002	punct	.,distributed
R5574	T8041	T8042	det	The,gradients
R5575	T8042	T8044	nsubj	gradients,are
R5576	T8043	T8042	nummod	three,gradients
R5577	T8045	T8044	acomp	close,are
R5578	T8046	T8045	cc	but,close
R5579	T8047	T8046	neg	not,but
R5580	T8048	T8045	conj	congruent,close
R5581	T8049	T8044	punct	", ",are
R5582	T8050	T8044	cc	and,are
R5583	T8051	T8052	nsubj	it,is
R5584	T8052	T8044	conj	is,are
R5585	T8053	T8054	poss	their,proximity
R5586	T8054	T8052	attr	proximity,is
R5587	T8055	T8056	dep	that,gives
R5588	T8056	T8052	ccomp	gives,is
R5589	T8057	T8056	dobj	rise,gives
R5590	T8058	T8056	prep	to,gives
R5591	T8059	T8060	det	the,distinction
R5592	T8060	T8058	pobj	distinction,to
R5593	T8061	T8060	amod	superficial,distinction
R5594	T8062	T8060	prep	between,distinction
R5595	T8063	T8064	amod	dorsal,skin
R5596	T8064	T8062	pobj	skin,between
R5597	T8065	T8063	cc	and,dorsal
R5598	T8066	T8063	conj	ventral,dorsal
R5599	T8067	T8064	prep	of,skin
R5600	T8068	T8069	nmod	at,at
R5601	T8069	T8071	compound	at,mice
R5602	T8070	T8069	punct	/,at
R5603	T8071	T8067	pobj	mice,of
R5604	T8072	T8052	punct	.,is
R5605	T8074	T8075	advmod	Indeed,give
R5606	T8076	T8075	punct	", ",give
R5607	T8077	T8078	amod	slight,differences
R5608	T8078	T8075	nsubj	differences,give
R5609	T8079	T8078	prep	between,differences
R5610	T8080	T8081	det	the,regions
R5611	T8081	T8079	pobj	regions,between
R5612	T8082	T8081	prep	of,regions
R5613	T8083	T8082	pobj	transition,of
R5614	T8084	T8081	prep	for,regions
R5615	T8085	T8086	compound	pigment,type
R5616	T8086	T8088	compound	type,switching
R5617	T8087	T8086	punct	-,type
R5618	T8088	T8084	pobj	switching,for
R5619	T8089	T8088	cc	and,switching
R5620	T8090	T8091	compound	pigment,content
R5621	T8091	T8088	conj	content,switching
R5622	T8092	T8075	dobj	rise,give
R5623	T8093	T8075	prep	to,give
R5624	T8094	T8095	det	a,stripe
R5625	T8095	T8093	pobj	stripe,to
R5626	T8096	T8095	amod	subtle,stripe
R5627	T8097	T8095	amod	yellow,stripe
R5628	T8098	T8095	prep	along,stripe
R5629	T8099	T8100	det	the,flank
R5630	T8100	T8098	pobj	flank,along
R5631	T8101	T8102	punct	(,see
R5632	T8102	T8075	parataxis	see,give
R5633	T8103	T8104	nmod	Figures,1
R5634	T8104	T8102	dobj	1,see
R5635	T8105	T8104	punct	", ",1
R5636	T8106	T8104	conj	2,1
R5637	T8107	T8106	punct	", ",2
R5638	T8108	T8106	cc	and,2
R5639	T8109	T8106	conj	9A,2
R5640	T8110	T8102	punct	),see
R5641	T8111	T8075	punct	.,give
R5642	T8113	T8114	nsubj	Levels,remain
R5643	T8115	T8113	prep	of,Levels
R5644	T8116	T8117	compound	Agouti,mRNA
R5645	T8117	T8115	pobj	mRNA,of
R5646	T8118	T8114	oprd	high,remain
R5647	T8119	T8114	prep	throughout,remain
R5648	T8120	T8121	det	the,ventrum
R5649	T8121	T8119	pobj	ventrum,throughout
R5650	T8122	T8121	amod	entire,ventrum
R5651	T8123	T8114	punct	", ",remain
R5652	T8124	T8114	cc	but,remain
R5653	T8125	T8126	compound	hair,content
R5654	T8126	T8128	nsubjpass	content,reduced
R5655	T8127	T8126	compound	pigment,content
R5656	T8128	T8114	conj	reduced,remain
R5657	T8129	T8128	auxpass	is,reduced
R5658	T8130	T8128	punct	", ",reduced
R5659	T8131	T8128	advcl	giving,reduced
R5660	T8132	T8131	dobj	rise,giving
R5661	T8133	T8131	prep	to,giving
R5662	T8134	T8135	det	a,region
R5663	T8135	T8133	pobj	region,to
R5664	T8136	T8137	npadvmod	cream,colored
R5665	T8137	T8135	amod	colored,region
R5666	T8138	T8137	punct	-,colored
R5667	T8139	T8135	prep	in,region
R5668	T8140	T8141	det	the,ventrum
R5669	T8141	T8139	pobj	ventrum,in
R5670	T8142	T8143	dep	that,appear
R5671	T8143	T8135	relcl	appear,region
R5672	T8144	T8143	punct	", ",appear
R5673	T8145	T8143	prep	depending,appear
R5674	T8146	T8145	prep	on,depending
R5675	T8147	T8146	pobj	age,on
R5676	T8148	T8147	cc	and,age
R5677	T8149	T8150	amod	genetic,backgrounds
R5678	T8150	T8147	conj	backgrounds,age
R5679	T8151	T8143	punct	", ",appear
R5680	T8152	T8143	aux	may,appear
R5681	T8153	T8154	advmod	more,distinct
R5682	T8154	T8143	oprd	distinct,appear
R5683	T8155	T8153	cc	or,more
R5684	T8156	T8153	conj	less,more
R5685	T8157	T8154	prep	from,distinct
R5686	T8158	T8159	det	the,stripe
R5687	T8159	T8157	pobj	stripe,from
R5688	T8160	T8159	amod	yellow,stripe
R5689	T8161	T8159	compound	flank,stripe
R5690	T8162	T8128	punct	.,reduced
R5691	T8164	T8165	nsubj	Loss,affects
R5692	T8165	T8168	ccomp	affects,are
R5693	T8166	T8164	prep	of,Loss
R5694	T8167	T8166	pobj	Tbx15,of
R5695	T8169	T8170	amod	dorsoventral,transitions
R5696	T8170	T8165	dobj	transitions,affects
R5697	T8171	T8170	prep	of,transitions
R5698	T8172	T8173	compound	hair,length
R5699	T8173	T8171	pobj	length,of
R5700	T8174	T8170	punct	", ",transitions
R5701	T8175	T8176	compound	pigment,content
R5702	T8176	T8170	conj	content,transitions
R5703	T8177	T8176	punct	", ",content
R5704	T8178	T8176	cc	and,content
R5705	T8179	T8176	conj	expression,content
R5706	T8180	T8179	prep	of,expression
R5707	T8181	T8182	det	the,isoform
R5708	T8182	T8180	pobj	isoform,of
R5709	T8183	T8184	amod	ventral,specific
R5710	T8184	T8182	amod	specific,isoform
R5711	T8185	T8184	punct	-,specific
R5712	T8186	T8182	compound	Agouti,isoform
R5713	T8187	T8168	punct	;,are
R5714	T8188	T8168	advmod	however,are
R5715	T8189	T8168	punct	", ",are
R5716	T8190	T8191	det	the,effects
R5717	T8191	T8168	nsubj	effects,are
R5718	T8192	T8191	amod	former,effects
R5719	T8193	T8191	nummod	two,effects
R5720	T8194	T8168	acomp	subtle,are
R5721	T8195	T8168	cc	and,are
R5722	T8196	T8168	conj	contribute,are
R5723	T8197	T8196	dobj	little,contribute
R5724	T8198	T8199	punct	", ",all
R5725	T8199	T8197	parataxis	all,little
R5726	T8200	T8199	mark	if,all
R5727	T8201	T8199	advmod	at,all
R5728	T8202	T8199	punct	", ",all
R5729	T8203	T8196	prep	to,contribute
R5730	T8204	T8205	det	the,pigmentation
R5731	T8205	T8203	pobj	pigmentation,to
R5732	T8206	T8205	amod	abnormal,pigmentation
R5733	T8207	T8205	prep	of,pigmentation
R5734	T8208	T8209	amod	adult,mice
R5735	T8209	T8207	pobj	mice,of
R5736	T8210	T8211	nmod	deH,deH
R5737	T8211	T8209	compound	deH,mice
R5738	T8212	T8211	punct	/,deH
R5739	T8213	T8168	punct	.,are
R5740	T8215	T8216	advmod	Thus,is
R5741	T8217	T8216	punct	", ",is
R5742	T8218	T8216	prep	despite,is
R5743	T8219	T8220	det	the,pattern
R5744	T8220	T8218	pobj	pattern,despite
R5745	T8221	T8220	amod	abnormal,pattern
R5746	T8222	T8220	prep	of,pattern
R5747	T8223	T8224	amod	dark,skin
R5748	T8224	T8222	pobj	skin,of
R5749	T8225	T8220	prep	in,pattern
R5750	T8226	T8227	amod	neonatal,mice
R5751	T8227	T8225	pobj	mice,in
R5752	T8228	T8229	nmod	deH,deH
R5753	T8229	T8227	compound	deH,mice
R5754	T8230	T8229	punct	/,deH
R5755	T8231	T8232	punct	(,Figure
R5756	T8232	T8220	parataxis	Figure,pattern
R5757	T8233	T8232	advmod	e.g.,Figure
R5758	T8234	T8232	punct	", ",Figure
R5759	T8235	T8232	nummod	2D,Figure
R5760	T8236	T8232	punct	),Figure
R5761	T8237	T8216	punct	", ",is
R5762	T8238	T8239	det	the,feature
R5763	T8239	T8216	nsubj	feature,is
R5764	T8240	T8241	advmod	most,obvious
R5765	T8241	T8239	amod	obvious,feature
R5766	T8242	T8239	prep	in,feature
R5767	T8243	T8242	pobj	adults,in
R5768	T8244	T8245	amod	dorsal,displacement
R5769	T8245	T8216	attr	displacement,is
R5770	T8246	T8245	prep	of,displacement
R5771	T8247	T8248	det	the,boundary
R5772	T8248	T8246	pobj	boundary,of
R5773	T8249	T8248	punct	“,boundary
R5774	T8250	T8248	punct	”,boundary
R5775	T8251	T8248	prep	between,boundary
R5776	T8252	T8253	amod	black,hair
R5777	T8253	T8251	pobj	hair,between
R5778	T8254	T8252	cc	and,black
R5779	T8255	T8252	conj	yellow,black
R5780	T8256	T8257	punct	(,Figure
R5781	T8257	T8216	parataxis	Figure,is
R5782	T8258	T8257	nummod	9A,Figure
R5783	T8259	T8257	punct	),Figure
R5784	T8260	T8216	punct	.,is
R5787	T8497	T8496	prep	of,Genetics
R5788	T8498	T8497	pobj	Tbx15,of
R5789	T8500	T8501	advcl	Named,identified
R5790	T8502	T8500	prep	for,Named
R5791	T8503	T8504	det	the,presence
R5792	T8504	T8502	pobj	presence,for
R5793	T8505	T8504	prep	of,presence
R5794	T8506	T8507	det	a,domain
R5795	T8507	T8505	pobj	domain,of
R5796	T8508	T8509	npadvmod	DNA,binding
R5797	T8509	T8507	amod	binding,domain
R5798	T8510	T8509	punct	-,binding
R5799	T8511	T8512	advmod	first,identified
R5800	T8512	T8507	acl	identified,domain
R5801	T8513	T8512	prep	in,identified
R5802	T8514	T8515	det	the,gene
R5803	T8515	T8513	pobj	gene,in
R5804	T8516	T8515	compound	mouse,gene
R5805	T8517	T8515	compound	Brachyury,gene
R5806	T8518	T8519	punct	(,causes
R5807	T8519	T8500	parataxis	causes,Named
R5808	T8520	T8519	nsubj	haploinsufficiency,causes
R5809	T8521	T8522	det	a,tail
R5810	T8522	T8519	dobj	tail,causes
R5811	T8523	T8522	amod	short,tail
R5812	T8524	T8519	punct	),causes
R5813	T8525	T8501	punct	", ",identified
R5814	T8526	T8527	compound	T,box
R5815	T8527	T8528	npadvmod	box,containing
R5816	T8528	T8530	amod	containing,genes
R5817	T8529	T8528	punct	–,containing
R5818	T8530	T8501	nsubjpass	genes,identified
R5819	T8531	T8501	aux	have,identified
R5820	T8532	T8501	auxpass	been,identified
R5821	T8533	T8501	prep	as,identified
R5822	T8534	T8535	amod	developmental,regulators
R5823	T8535	T8533	pobj	regulators,as
R5824	T8536	T8501	prep	in,identified
R5825	T8537	T8538	det	a,spectrum
R5826	T8538	T8536	pobj	spectrum,in
R5827	T8539	T8538	amod	wide,spectrum
R5828	T8540	T8538	prep	of,spectrum
R5829	T8541	T8540	pobj	tissues,of
R5830	T8542	T8541	cc	and,tissues
R5831	T8543	T8544	amod	multicellular,organisms
R5832	T8544	T8541	conj	organisms,tissues
R5833	T8545	T8546	punct	(,reviewed
R5834	T8546	T8501	parataxis	reviewed,identified
R5835	T8547	T8546	prep	in,reviewed
R5836	T8548	T8547	pobj	Papaioannou,in
R5837	T8549	T8548	npadvmod	2001,Papaioannou
R5838	T8550	T8546	punct	),reviewed
R5839	T8551	T8501	punct	.,identified
R5840	T8553	T8554	det	The,subfamily
R5841	T8554	T8556	nsubj	subfamily,is
R5842	T8555	T8554	compound	Tbx15,subfamily
R5843	T8557	T8554	punct	", ",subfamily
R5844	T8558	T8559	dep	which,includes
R5845	T8559	T8554	relcl	includes,subfamily
R5846	T8560	T8559	advmod	also,includes
R5847	T8561	T8559	dobj	Tbx18,includes
R5848	T8562	T8561	cc	and,Tbx18
R5849	T8563	T8561	conj	Tbx22,Tbx18
R5850	T8564	T8556	punct	", ",is
R5851	T8565	T8556	acomp	likely,is
R5852	T8566	T8567	aux	to,arisen
R5853	T8567	T8565	xcomp	arisen,likely
R5854	T8568	T8567	aux	have,arisen
R5855	T8569	T8567	prep	during,arisen
R5856	T8570	T8571	amod	early,evolution
R5857	T8571	T8569	pobj	evolution,during
R5858	T8572	T8571	compound	chordate,evolution
R5859	T8573	T8574	mark	since,is
R5860	T8574	T8567	advcl	is,arisen
R5861	T8575	T8574	expl	there,is
R5862	T8576	T8577	det	a,gene
R5863	T8577	T8574	attr	gene,is
R5864	T8578	T8577	amod	single,gene
R5865	T8579	T8577	prep	in,gene
R5866	T8580	T8579	pobj	amphioxus,in
R5867	T8581	T8577	cc	but,gene
R5868	T8582	T8583	det	no,homolog
R5869	T8583	T8577	conj	homolog,gene
R5870	T8584	T8583	amod	obvious,homolog
R5871	T8585	T8583	prep	in,homolog
R5872	T8586	T8587	det	the,genome
R5873	T8587	T8585	pobj	genome,in
R5874	T8588	T8587	compound	fly,genome
R5875	T8589	T8590	punct	(,Ruvinsky
R5876	T8590	T8574	meta	Ruvinsky,is
R5877	T8591	T8590	nmod	et,Ruvinsky
R5878	T8592	T8590	nmod	al.,Ruvinsky
R5879	T8593	T8590	nummod	2000,Ruvinsky
R5880	T8594	T8590	punct	),Ruvinsky
R5881	T8595	T8556	punct	.,is
R5882	T8597	T8598	advcl	Consistent,expressed
R5883	T8599	T8597	prep	with,Consistent
R5884	T8600	T8601	det	this,relationship
R5885	T8601	T8599	pobj	relationship,with
R5886	T8602	T8598	punct	", ",expressed
R5887	T8603	T8604	det	the,genes
R5888	T8604	T8598	nsubjpass	genes,expressed
R5889	T8605	T8604	nummod	three,genes
R5890	T8606	T8598	auxpass	are,expressed
R5891	T8607	T8598	prep	in,expressed
R5892	T8608	T8609	advmod	partially,overlapping
R5893	T8609	T8610	amod	overlapping,patterns
R5894	T8610	T8607	pobj	patterns,in
R5895	T8611	T8612	dep	that,include
R5896	T8612	T8610	relcl	include,patterns
R5897	T8613	T8614	amod	anterior,somites
R5898	T8614	T8612	dobj	somites,include
R5899	T8615	T8616	punct	(,Tbx18
R5900	T8616	T8614	parataxis	Tbx18,somites
R5901	T8617	T8616	cc	and,Tbx18
R5902	T8618	T8616	conj	Tbx22,Tbx18
R5903	T8619	T8616	punct	),Tbx18
R5904	T8620	T8614	punct	", ",somites
R5905	T8621	T8622	compound	limb,mesenchyme
R5906	T8622	T8614	conj	mesenchyme,somites
R5907	T8623	T8624	punct	(,Tbx15
R5908	T8624	T8622	parataxis	Tbx15,mesenchyme
R5909	T8625	T8624	cc	and,Tbx15
R5910	T8626	T8624	conj	Tbx18,Tbx15
R5911	T8627	T8624	punct	),Tbx15
R5912	T8628	T8622	punct	", ",mesenchyme
R5913	T8629	T8622	cc	and,mesenchyme
R5914	T8630	T8631	amod	craniofacial,mesenchyme
R5915	T8631	T8622	conj	mesenchyme,mesenchyme
R5916	T8632	T8633	punct	(,genes
R5917	T8633	T8631	parataxis	genes,mesenchyme
R5918	T8634	T8633	det	all,genes
R5919	T8635	T8633	nummod	three,genes
R5920	T8636	T8633	punct	", ",genes
R5921	T8637	T8633	dep	Tbx15,genes
R5922	T8638	T8639	advmod	more,broadly
R5923	T8639	T8637	advmod	broadly,Tbx15
R5924	T8640	T8639	prep	than,broadly
R5925	T8641	T8640	pobj	Tbx18,than
R5926	T8642	T8641	cc	or,Tbx18
R5927	T8643	T8641	conj	Tbx22,Tbx18
R5928	T8644	T8633	punct	),genes
R5929	T8645	T8646	punct	(,Agulnik
R5930	T8646	T8612	meta	Agulnik,include
R5931	T8647	T8646	nmod	et,Agulnik
R5932	T8648	T8646	nmod	al.,Agulnik
R5933	T8649	T8646	nummod	1998,Agulnik
R5934	T8650	T8646	punct	;,Agulnik
R5935	T8651	T8646	nmod	Kraus,Agulnik
R5936	T8652	T8646	nmod	et,Agulnik
R5937	T8653	T8646	nmod	al.,Agulnik
R5938	T8654	T8646	nummod	2001,Agulnik
R5939	T8655	T8646	punct	;,Agulnik
R5940	T8656	T8646	nmod	Braybrook,Agulnik
R5941	T8657	T8646	nmod	et,Agulnik
R5942	T8658	T8646	nmod	al.,Agulnik
R5943	T8659	T8646	nummod	2002,Agulnik
R5944	T8660	T8646	punct	;,Agulnik
R5945	T8661	T8646	nmod	Bush,Agulnik
R5946	T8662	T8646	nmod	et,Agulnik
R5947	T8663	T8646	nmod	al.,Agulnik
R5948	T8664	T8646	nummod	2002,Agulnik
R5949	T8665	T8646	punct	;,Agulnik
R5950	T8666	T8646	nmod	Herr,Agulnik
R5951	T8667	T8646	nmod	et,Agulnik
R5952	T8668	T8646	nmod	al.,Agulnik
R5953	T8669	T8646	nummod	2003,Agulnik
R5954	T8670	T8646	punct	),Agulnik
R5955	T8671	T8598	punct	.,expressed
R5956	T8673	T8674	det	These,observations
R5957	T8674	T8675	nsubj	observations,suggest
R5958	T8676	T8677	mark	that,been
R5960	T8678	T8679	det	an,gene
R5961	T8679	T8677	nsubj	gene,been
R5962	T8680	T8679	amod	ancestral,gene
R5963	T8681	T8679	prep	for,gene
R5964	T8682	T8681	pobj	Tbx15,for
R5965	T8683	T8682	punct	", ",Tbx15
R5966	T8684	T8682	conj	Tbx18,Tbx15
R5967	T8685	T8684	punct	", ",Tbx18
R5968	T8686	T8684	cc	and,Tbx18
R5969	T8687	T8684	conj	Tbx22,Tbx18
R5970	T8688	T8677	aux	may,been
R5971	T8689	T8677	aux	have,been
R5972	T8690	T8677	acomp	important,been
R5973	T8691	T8677	prep	for,been
R5974	T8692	T8693	amod	craniofacial,development
R5975	T8693	T8691	pobj	development,for
R5976	T8694	T8693	prep	in,development
R5977	T8695	T8694	pobj	cephalochordates,in
R5978	T8696	T8677	punct	", ",been
R5979	T8697	T8677	prep	with,been
R5980	T8698	T8697	pobj	acquisition,with
R5981	T8699	T8698	prep	of,acquisition
R5982	T8700	T8701	amod	additional,patterns
R5983	T8701	T8699	pobj	patterns,of
R5984	T8702	T8701	compound	expression,patterns
R5985	T8703	T8701	cc	and,patterns
R5986	T8704	T8705	amod	developmental,functions
R5987	T8705	T8701	conj	functions,patterns
R5988	T8706	T8698	prep	in,acquisition
R5989	T8707	T8708	det	the,limb
R5990	T8708	T8706	pobj	limb,in
R5991	T8709	T8708	cc	and,limb
R5992	T8710	T8711	det	the,trunk
R5993	T8711	T8708	conj	trunk,limb
R5994	T8712	T8698	prep	during,acquisition
R5995	T8713	T8714	amod	early,evolution
R5996	T8714	T8712	pobj	evolution,during
R5997	T8715	T8714	compound	vertebrate,evolution
R5998	T8716	T8675	punct	.,suggest
R5999	T8718	T8719	nsubjpass	Expression,reported
R6000	T8720	T8718	prep	of,Expression
R6001	T8721	T8720	pobj	Tbx18,of
R6002	T8722	T8721	cc	and,Tbx18
R6003	T8723	T8721	conj	Tbx22,Tbx18
R6004	T8724	T8719	aux	has,reported
R6005	T8725	T8719	neg	not,reported
R6006	T8726	T8719	auxpass	been,reported
R6007	T8727	T8719	prep	in,reported
R6008	T8728	T8729	amod	embryonic,mesenchyme
R6009	T8729	T8727	pobj	mesenchyme,in
R6010	T8730	T8729	compound	flank,mesenchyme
R6011	T8731	T8719	punct	", ",reported
R6012	T8732	T8733	dep	which,suggests
R6013	T8733	T8719	advcl	suggests,reported
R6014	T8734	T8735	mark	that,is
R6015	T8735	T8733	ccomp	is,suggests
R6016	T8736	T8735	nsubj	Tbx15,is
R6017	T8737	T8738	det	the,member
R6018	T8738	T8735	attr	member,is
R6019	T8739	T8738	amod	only,member
R6020	T8740	T8738	compound	family,member
R6021	T8741	T8738	acl	involved,member
R6022	T8742	T8741	prep	in,involved
R6023	T8743	T8742	pcomp	establishing,in
R6024	T8744	T8745	det	the,identity
R6025	T8745	T8743	dobj	identity,establishing
R6026	T8746	T8745	amod	dorsoventral,identity
R6027	T8747	T8745	prep	of,identity
R6028	T8748	T8749	det	the,trunk
R6029	T8749	T8747	pobj	trunk,of
R6030	T8750	T8719	punct	.,reported
R6031	T8752	T8753	advmod	However,be
R6032	T8754	T8753	punct	", ",be
R6033	T8755	T8753	nsubj	it,be
R6034	T8756	T8753	aux	would,be
R6035	T8757	T8753	neg	not,be
R6036	T8758	T8753	acomp	surprising,be
R6037	T8759	T8760	aux	to,find
R6038	T8760	T8753	xcomp	find,be
R6039	T8761	T8762	det	some,degree
R6040	T8762	T8760	dobj	degree,find
R6041	T8763	T8762	prep	of,degree
R6042	T8764	T8765	amod	functional,redundancy
R6043	T8765	T8763	pobj	redundancy,of
R6044	T8766	T8760	prep	in,find
R6045	T8767	T8766	pobj	animals,in
R6046	T8768	T8767	acl	mutated,animals
R6047	T8769	T8768	prep	for,mutated
R6048	T8770	T8769	pobj	two,for
R6049	T8771	T8770	cc	or,two
R6050	T8772	T8770	conj	three,two
R6051	T8773	T8770	prep	of,two
R6052	T8774	T8775	det	the,members
R6053	T8775	T8773	pobj	members,of
R6054	T8776	T8775	compound	subfamily,members
R6055	T8777	T8760	prep	in,find
R6056	T8778	T8779	amod	other,regions
R6057	T8779	T8777	pobj	regions,in
R6058	T8780	T8779	compound	body,regions
R6059	T8781	T8779	punct	", ",regions
R6060	T8782	T8783	advmod	particularly,limbs
R6061	T8783	T8779	appos	limbs,regions
R6062	T8784	T8783	det	the,limbs
R6063	T8785	T8783	cc	and,limbs
R6064	T8786	T8787	det	the,head
R6065	T8787	T8783	conj	head,limbs
R6066	T8788	T8753	punct	.,be
R6067	T8790	T8791	prep	For,cause
R6068	T8792	T8790	pobj	example,For
R6069	T8793	T8791	punct	", ",cause
R6070	T8794	T8791	nsubj	mutations,cause
R6071	T8795	T8794	prep	in,mutations
R6072	T8796	T8795	pobj	Tbx22,in
R6073	T8797	T8798	det	the,syndrome
R6074	T8798	T8791	dobj	syndrome,cause
R6075	T8799	T8798	amod	human,syndrome
R6076	T8800	T8801	npadvmod	X,linked
R6077	T8801	T8803	amod	linked,palate
R6078	T8802	T8801	punct	-,linked
R6079	T8803	T8798	appos	palate,syndrome
R6080	T8804	T8803	amod	cleft,palate
R6081	T8805	T8803	cc	and,palate
R6082	T8806	T8803	conj	ankyloglossia,palate
R6083	T8807	T8808	punct	(,Braybrook
R6084	T8808	T8791	meta	Braybrook,cause
R6085	T8809	T8808	nmod	et,Braybrook
R6086	T8810	T8808	nmod	al.,Braybrook
R6087	T8811	T8808	nummod	2001,Braybrook
R6088	T8812	T8808	punct	),Braybrook
R6089	T8813	T8791	punct	.,cause
R6090	T8815	T8816	prep	Despite,affect
R6091	T8817	T8818	amod	high,levels
R6092	T8818	T8815	pobj	levels,Despite
R6093	T8819	T8818	prep	of,levels
R6094	T8820	T8821	compound	Tbx22,expression
R6095	T8821	T8819	pobj	expression,of
R6096	T8822	T8818	prep	in,levels
R6097	T8823	T8824	amod	periocular,mesenchyme
R6098	T8824	T8822	pobj	mesenchyme,in
R6099	T8825	T8824	amod	embryonic,mesenchyme
R6100	T8826	T8827	punct	(,Braybrook
R6101	T8827	T8818	meta	Braybrook,levels
R6102	T8828	T8827	nmod	et,Braybrook
R6103	T8829	T8827	nmod	al.,Braybrook
R6104	T8830	T8827	nummod	2002,Braybrook
R6105	T8831	T8827	punct	;,Braybrook
R6106	T8832	T8827	nmod	Bush,Braybrook
R6107	T8833	T8827	nmod	et,Braybrook
R6108	T8834	T8827	nmod	al.,Braybrook
R6109	T8835	T8827	nummod	2002,Braybrook
R6110	T8836	T8827	punct	;,Braybrook
R6111	T8837	T8827	nmod	Herr,Braybrook
R6112	T8838	T8827	nmod	et,Braybrook
R6113	T8839	T8827	nmod	al.,Braybrook
R6114	T8840	T8827	nummod	2003,Braybrook
R6115	T8841	T8827	punct	),Braybrook
R6116	T8842	T8816	punct	", ",affect
R6117	T8843	T8844	det	the,condition
R6118	T8844	T8816	nsubj	condition,affect
R6119	T8845	T8816	aux	does,affect
R6120	T8846	T8816	neg	not,affect
R6121	T8847	T8848	det	the,eye
R6122	T8848	T8816	dobj	eye,affect
R6123	T8849	T8816	punct	", ",affect
R6124	T8850	T8851	advmod	perhaps,provided
R6125	T8851	T8816	advcl	provided,affect
R6126	T8852	T8851	mark	because,provided
R6127	T8853	T8854	amod	residual,activity
R6128	T8854	T8851	nsubjpass	activity,provided
R6129	T8855	T8851	auxpass	is,provided
R6130	T8856	T8851	agent	by,provided
R6131	T8857	T8856	pobj	Tbx15,by
R6132	T8858	T8851	prep	in,provided
R6133	T8859	T8860	det	the,region
R6134	T8860	T8858	pobj	region,in
R6135	T8861	T8860	amod	same,region
R6136	T8862	T8816	punct	.,affect
R6137	T8864	T8865	prep	In,suggested
R6138	T8866	T8867	det	an,description
R6139	T8867	T8864	pobj	description,In
R6140	T8868	T8867	amod	initial,description
R6141	T8869	T8867	prep	of,description
R6142	T8870	T8871	det	the,expression
R6143	T8871	T8869	pobj	expression,of
R6144	T8872	T8871	cc	and,expression
R6145	T8873	T8874	compound	map,location
R6146	T8874	T8871	conj	location,expression
R6147	T8875	T8871	prep	of,expression
R6148	T8876	T8877	compound	mouse,Tbx15
R6149	T8877	T8875	pobj	Tbx15,of
R6150	T8878	T8865	punct	", ",suggested
R6151	T8879	T8865	nsubj	Agulnik,suggested
R6152	T8880	T8881	advmod	et,al.
R6153	T8881	T8879	advmod	al.,Agulnik
R6154	T8882	T8879	punct	(,Agulnik
R6155	T8883	T8879	npadvmod	1998,Agulnik
R6156	T8884	T8879	punct	),Agulnik
R6157	T8885	T8886	amod	human,Tbx15
R6158	T8886	T8865	dobj	Tbx15,suggested
R6159	T8887	T8888	dep	that,lies
R6160	T8888	T8886	relcl	lies,Tbx15
R6161	T8889	T8888	prep	on,lies
R6162	T8890	T8891	compound	Chromosome,1p11.1
R6163	T8891	T8889	pobj	1p11.1,on
R6164	T8892	T8865	prep	as,suggested
R6165	T8893	T8894	det	a,candidate
R6166	T8894	T8892	pobj	candidate,as
R6167	T8895	T8894	prep	for,candidate
R6168	T8896	T8897	amod	acromegaloid,appearance
R6169	T8897	T8899	nmod	appearance,syndrome
R6170	T8898	T8897	amod	facial,appearance
R6171	T8899	T8895	pobj	syndrome,for
R6172	T8900	T8897	punct	(,appearance
R6173	T8901	T8897	appos	AFA,appearance
R6174	T8902	T8899	punct	),syndrome
R6175	T8903	T8899	punct	", ",syndrome
R6176	T8904	T8905	prep	for,is
R6177	T8905	T8899	relcl	is,syndrome
R6178	T8906	T8904	pobj	which,for
R6179	T8907	T8905	expl	there,is
R6180	T8908	T8909	det	a,score
R6181	T8909	T8905	attr	score,is
R6182	T8910	T8909	amod	weak,score
R6183	T8911	T8909	amod	positive,score
R6184	T8912	T8909	compound	LOD,score
R6185	T8913	T8909	prep	to,score
R6186	T8914	T8915	compound	Chromosome,1p
R6187	T8915	T8913	pobj	1p,to
R6188	T8916	T8917	punct	(,Hughes
R6189	T8917	T8905	meta	Hughes,is
R6190	T8918	T8917	nmod	et,Hughes
R6191	T8919	T8917	nmod	al.,Hughes
R6192	T8920	T8917	nummod	1985,Hughes
R6193	T8921	T8917	punct	),Hughes
R6194	T8922	T8865	punct	.,suggested
R6195	T8924	T8925	advmod	Originally,described
R6196	T8925	T8926	advcl	described,describe
R6197	T8927	T8925	prep	as,described
R6198	T8928	T8929	det	a,syndrome
R6199	T8929	T8927	pobj	syndrome,as
R6200	T8930	T8929	amod	rare,syndrome
R6201	T8931	T8932	amod	autosomal,dominant
R6202	T8932	T8929	amod	dominant,syndrome
R6203	T8933	T8932	punct	-,dominant
R6204	T8934	T8929	prep	with,syndrome
R6205	T8935	T8936	amod	progressive,coarsening
R6206	T8936	T8934	pobj	coarsening,with
R6207	T8937	T8936	amod	facial,coarsening
R6208	T8938	T8936	punct	", ",coarsening
R6209	T8939	T8936	conj	overgrowth,coarsening
R6210	T8940	T8939	prep	of,overgrowth
R6211	T8941	T8942	det	the,mucosa
R6212	T8942	T8940	pobj	mucosa,of
R6213	T8943	T8942	amod	intraoral,mucosa
R6214	T8944	T8939	punct	", ",overgrowth
R6215	T8945	T8939	cc	and,overgrowth
R6216	T8946	T8947	amod	large,hands
R6217	T8947	T8939	conj	hands,overgrowth
R6218	T8948	T8947	punct	", ",hands
R6219	T8949	T8947	amod	doughy,hands
R6220	T8950	T8926	punct	", ",describe
R6221	T8951	T8952	advmod	more,recent
R6222	T8952	T8953	amod	recent,reports
R6223	T8953	T8926	nsubj	reports,describe
R6224	T8954	T8953	compound	case,reports
R6225	T8955	T8926	dobj	macrosomia,describe
R6226	T8956	T8955	punct	", ",macrosomia
R6227	T8957	T8955	conj	macrocephaly,macrosomia
R6228	T8958	T8957	punct	", ",macrocephaly
R6229	T8959	T8957	cc	or,macrocephaly
R6230	T8960	T8957	conj	both,macrocephaly
R6231	T8961	T8955	cc	and,macrosomia
R6232	T8962	T8963	amod	generalized,hypertrichosis
R6233	T8963	T8955	conj	hypertrichosis,macrosomia
R6234	T8964	T8926	prep	with,describe
R6235	T8965	T8966	amod	progressive,coarsening
R6236	T8966	T8964	pobj	coarsening,with
R6237	T8967	T8968	punct	(,Dallapiccola
R6238	T8968	T8926	meta	Dallapiccola,describe
R6239	T8969	T8968	nmod	et,Dallapiccola
R6240	T8970	T8968	nmod	al.,Dallapiccola
R6241	T8971	T8968	nummod	1992,Dallapiccola
R6242	T8972	T8968	punct	;,Dallapiccola
R6243	T8973	T8968	nmod	Irvine,Dallapiccola
R6244	T8974	T8968	nmod	et,Dallapiccola
R6245	T8975	T8968	nmod	al.,Dallapiccola
R6246	T8976	T8968	nummod	1996,Dallapiccola
R6247	T8977	T8968	punct	;,Dallapiccola
R6248	T8978	T8968	nmod	da,Dallapiccola
R6249	T8979	T8968	nmod	Silva,Dallapiccola
R6250	T8980	T8968	nmod	et,Dallapiccola
R6251	T8981	T8968	nmod	al.,Dallapiccola
R6252	T8982	T8968	nummod	1998,Dallapiccola
R6253	T8983	T8968	punct	;,Dallapiccola
R6254	T8984	T8968	nmod	Zelante,Dallapiccola
R6255	T8985	T8968	nmod	et,Dallapiccola
R6256	T8986	T8968	nmod	al.,Dallapiccola
R6257	T8987	T8968	nummod	2000,Dallapiccola
R6258	T8988	T8968	punct	),Dallapiccola
R6259	T8989	T8926	punct	.,describe
R6260	T8991	T8992	det	The,phenotype
R6261	T8992	T8994	nsubj	phenotype,exhibits
R6262	T8993	T8992	compound	deH,phenotype
R6263	T8994	T8995	ccomp	exhibits,suggest
R6264	T8996	T8997	amod	little,overlap
R6265	T8997	T8994	dobj	overlap,exhibits
R6266	T8998	T8997	prep	with,overlap
R6267	T8999	T9000	det	these,features
R6268	T9000	T8998	pobj	features,with
R6269	T9001	T8995	punct	;,suggest
R6270	T9002	T8995	advmod	instead,suggest
R6271	T9003	T8995	punct	", ",suggest
R6272	T9004	T8995	nsubj	we,suggest
R6273	T9005	T9006	det	a,candidate
R6274	T9006	T9009	nsubj	candidate,be
R6275	T9007	T9008	advmod	more,likely
R6276	T9008	T9006	amod	likely,candidate
R6277	T9009	T8995	advcl	be,suggest
R6278	T9010	T9006	prep	for,candidate
R6279	T9011	T9010	pobj	mutations,for
R6280	T9012	T9011	prep	of,mutations
R6281	T9013	T9014	amod	human,TBX15
R6282	T9014	T9012	pobj	TBX15,of
R6283	T9015	T9009	aux	would,be
R6284	T9016	T9017	amod	frontofacionasal,syndrome
R6285	T9017	T9009	attr	syndrome,be
R6286	T9018	T9017	punct	", ",syndrome
R6287	T9019	T9020	det	an,condition
R6288	T9020	T9017	appos	condition,syndrome
R6289	T9021	T9020	amod	unmapped,condition
R6290	T9022	T9020	amod	autosomal,condition
R6291	T9023	T9020	amod	recessive,condition
R6292	T9024	T9020	acl	characterized,condition
R6293	T9025	T9024	agent	by,characterized
R6294	T9026	T9025	pobj	brachycephaly,by
R6295	T9027	T9026	punct	", ",brachycephaly
R6296	T9028	T9026	conj	blepharophimosis,brachycephaly
R6297	T9029	T9028	punct	", ",blepharophimosis
R6298	T9030	T9028	cc	and,blepharophimosis
R6299	T9031	T9032	amod	midface,hypoplasia
R6300	T9032	T9028	conj	hypoplasia,blepharophimosis
R6301	T9033	T9034	punct	(,Reardon
R6302	T9034	T9024	meta	Reardon,characterized
R6303	T9035	T9034	nmod	et,Reardon
R6304	T9036	T9034	nmod	al.,Reardon
R6305	T9037	T9034	nummod	1994,Reardon
R6306	T9038	T9034	punct	),Reardon
R6307	T9039	T8995	punct	.,suggest
R6308	T9041	T9042	nsubj	Two,became
R6309	T9043	T9041	prep	of,Two
R6310	T9044	T9043	pobj	us,of
R6311	T9045	T9041	punct	(,Two
R6312	T9046	T9047	compound	S.,Kuijper
R6313	T9047	T9041	appos	Kuijper,Two
R6314	T9048	T9047	cc	and,Kuijper
R6315	T9049	T9050	compound	F.,Meijlink
R6316	T9050	T9047	conj	Meijlink,Kuijper
R6317	T9051	T9042	punct	),became
R6318	T9052	T9042	acomp	interested,became
R6319	T9053	T9052	prep	in,interested
R6320	T9054	T9055	det	the,mutation
R6321	T9055	T9053	pobj	mutation,in
R6322	T9056	T9055	compound	deH,mutation
R6323	T9057	T9042	prep	because,became
R6324	T9058	T9057	pcomp	of,because
R6325	T9059	T9060	poss	its,effects
R6326	T9060	T9057	pobj	effects,because
R6327	T9061	T9060	prep	on,effects
R6328	T9062	T9063	amod	skeletal,development
R6329	T9063	T9061	pobj	development,on
R6330	T9064	T9065	punct	(,Curry
R6331	T9065	T9060	meta	Curry,effects
R6332	T9066	T9065	nummod	1959,Curry
R6333	T9067	T9065	punct	),Curry
R6334	T9068	T9060	cc	and,effects
R6335	T9069	T9070	det	the,possibility
R6336	T9070	T9060	conj	possibility,effects
R6337	T9071	T9072	mark	that,be
R6338	T9072	T9070	acl	be,possibility
R6339	T9073	T9074	det	the,gene
R6340	T9074	T9072	nsubj	gene,be
R6341	T9075	T9076	npadvmod	aristaless,related
R6342	T9076	T9074	amod	related,gene
R6343	T9077	T9076	punct	-,related
R6344	T9078	T9074	appos	Alx3,gene
R6345	T9079	T9072	aux	might,be
R6346	T9080	T9072	acomp	allelic,be
R6347	T9081	T9080	prep	with,allelic
R6348	T9082	T9083	amod	droopy,ear
R6349	T9083	T9081	pobj	ear,with
R6350	T9084	T9085	punct	(,ten
R6351	T9085	T9072	meta	ten,be
R6352	T9086	T9085	nmod	Berge,ten
R6353	T9087	T9085	nmod	et,ten
R6354	T9088	T9085	nmod	al.,ten
R6355	T9089	T9085	nummod	1998,ten
R6356	T9090	T9085	punct	),ten
R6357	T9091	T9042	punct	.,became
R6358	T9093	T9094	prep	In,excluded
R6359	T9095	T9093	pobj	spite,In
R6360	T9096	T9095	prep	of,spite
R6361	T9097	T9096	pobj	similarities,of
R6362	T9098	T9097	prep	between,similarities
R6363	T9099	T9100	amod	skeletal,phenotypes
R6364	T9100	T9098	pobj	phenotypes,between
R6365	T9101	T9100	prep	of,phenotypes
R6366	T9102	T9103	nmod	deH,mutants
R6367	T9103	T9101	pobj	mutants,of
R6368	T9104	T9102	cc	and,deH
R6369	T9105	T9102	conj	Alx3,deH
R6370	T9106	T9105	cc	or,Alx3
R6371	T9107	T9105	conj	Alx4,Alx3
R6372	T9108	T9094	punct	", ",excluded
R6373	T9109	T9110	amod	subsequent,experiments
R6374	T9110	T9094	nsubj	experiments,excluded
R6375	T9111	T9112	punct	(,data
R6376	T9112	T9110	meta	data,experiments
R6377	T9113	T9112	amod	unpublished,data
R6378	T9114	T9112	punct	),data
R6379	T9115	T9094	dobj	allelism,excluded
R6380	T9116	T9115	prep	of,allelism
R6381	T9117	T9116	pobj	Alx3,of
R6382	T9118	T9117	cc	and,Alx3
R6383	T9119	T9117	conj	deH,Alx3
R6384	T9120	T9094	punct	", ",excluded
R6385	T9121	T9094	cc	and,excluded
R6386	T9122	T9123	det	a,description
R6387	T9123	T9125	nsubjpass	description,published
R6388	T9124	T9123	amod	full,description
R6389	T9125	T9094	conj	published,excluded
R6390	T9126	T9123	prep	of,description
R6391	T9127	T9128	det	the,phenotype
R6392	T9128	T9126	pobj	phenotype,of
R6393	T9129	T9128	nmod	Tbx15,phenotype
R6394	T9130	T9128	amod	skeletal,phenotype
R6395	T9131	T9125	aux	will,published
R6396	T9132	T9125	auxpass	be,published
R6397	T9133	T9125	advmod	elsewhere,published
R6398	T9134	T9094	punct	.,excluded
R6406	T9366	T9367	amod	Developmental,Mechanism
R6407	T9368	T9367	prep	of,Mechanism
R6408	T9369	T9370	compound	Tbx15,Expression
R6409	T9370	T9368	pobj	Expression,of
R6410	T9371	T9370	cc	and,Expression
R6411	T9372	T9370	conj	Action,Expression
R6412	T9373	T9370	prep	in,Expression
R6413	T9374	T9375	det	the,Skin
R6414	T9375	T9373	pobj	Skin,in
R6415	T9377	T9378	poss	Our,attention
R6416	T9378	T9379	nsubjpass	attention,motivated
R6417	T9380	T9378	prep	to,attention
R6418	T9381	T9382	det	the,role
R6419	T9382	T9380	pobj	role,to
R6420	T9383	T9382	prep	of,role
R6421	T9384	T9383	pobj	Tbx15,of
R6422	T9385	T9382	prep	in,role
R6423	T9386	T9387	compound	pigment,patterning
R6424	T9387	T9385	pobj	patterning,in
R6425	T9388	T9379	auxpass	was,motivated
R6426	T9389	T9379	agent	by,motivated
R6427	T9390	T9391	det	the,effects
R6428	T9391	T9389	pobj	effects,by
R6429	T9392	T9391	prep	of,effects
R6430	T9393	T9392	pobj	Agouti,of
R6431	T9394	T9391	prep	in,effects
R6432	T9395	T9396	amod	postnatal,animals
R6433	T9396	T9394	pobj	animals,in
R6434	T9397	T9379	punct	.,motivated
R6435	T9399	T9400	advmod	However,expressed
R6436	T9401	T9400	punct	", ",expressed
R6437	T9402	T9400	nsubjpass	Agouti,expressed
R6438	T9403	T9400	auxpass	is,expressed
R6439	T9404	T9400	advmod	also,expressed
R6440	T9405	T9400	prep	in,expressed
R6441	T9406	T9407	det	the,embryo
R6442	T9407	T9405	pobj	embryo,in
R6443	T9408	T9407	punct	", ",embryo
R6444	T9409	T9410	advmod	where,provides
R6445	T9410	T9407	relcl	provides,embryo
R6446	T9411	T9410	nsubj	it,provides
R6447	T9412	T9413	det	a,marker
R6448	T9413	T9410	dobj	marker,provides
R6449	T9414	T9413	amod	convenient,marker
R6450	T9415	T9413	prep	of,marker
R6451	T9416	T9417	amod	ventral,identity
R6452	T9417	T9415	pobj	identity,of
R6453	T9418	T9417	compound	dermis,identity
R6454	T9419	T9400	punct	.,expressed
R6455	T9421	T9422	mark	Because,is
R6456	T9422	T9435	advcl	is,occur
R6457	T9423	T9424	det	an,domain
R6458	T9424	T9422	nsubj	domain,is
R6459	T9425	T9424	amod	expanded,domain
R6460	T9426	T9424	prep	of,domain
R6461	T9427	T9428	amod	embryonic,expression
R6462	T9428	T9426	pobj	expression,of
R6463	T9429	T9428	compound	Agouti,expression
R6464	T9430	T9424	prep	in,domain
R6465	T9431	T9432	compound	deH,deH
R6466	T9432	T9434	compound	deH,animals
R6467	T9433	T9432	punct	/,deH
R6468	T9434	T9430	pobj	animals,in
R6469	T9436	T9422	acomp	detectable,is
R6470	T9437	T9422	prep	by,is
R6471	T9438	T9437	pobj	E14.5,by
R6472	T9439	T9435	punct	", ",occur
R6473	T9440	T9441	det	the,effects
R6474	T9441	T9435	nsubj	effects,occur
R6475	T9442	T9441	prep	of,effects
R6476	T9443	T9442	pobj	Tbx15,of
R6477	T9444	T9441	prep	on,effects
R6478	T9445	T9446	amod	dorsoventral,patterning
R6479	T9446	T9444	pobj	patterning,on
R6480	T9447	T9435	aux	must,occur
R6481	T9448	T9435	advmod	prior,occur
R6482	T9449	T9448	prep	to,prior
R6483	T9450	T9451	det	this,time
R6484	T9451	T9449	pobj	time,to
R6485	T9452	T9435	punct	.,occur
R6486	T9454	T9455	prep	Among,emerged
R6487	T9456	T9457	amod	other,genes
R6488	T9457	T9454	pobj	genes,Among
R6489	T9458	T9459	compound	T,box
R6490	T9459	T9457	compound	box,genes
R6491	T9460	T9459	punct	-,box
R6492	T9461	T9462	poss	whose,actions
R6493	T9462	T9464	dep	actions,understood
R6494	T9463	T9462	amod	developmental,actions
R6495	T9464	T9457	relcl	understood,genes
R6496	T9465	T9464	auxpass	are,understood
R6497	T9466	T9467	advmod	at,least
R6498	T9467	T9468	advmod	least,partially
R6499	T9468	T9464	advmod	partially,understood
R6500	T9469	T9455	punct	", ",emerged
R6501	T9470	T9471	nummod	two,themes
R6502	T9471	T9455	nsubj	themes,emerged
R6503	T9472	T9471	amod	general,themes
R6504	T9473	T9455	aux	have,emerged
R6505	T9474	T9455	punct	", ",emerged
R6506	T9475	T9476	nsubj	one,focused
R6507	T9476	T9455	advcl	focused,emerged
R6508	T9477	T9476	prep	on,focused
R6509	T9478	T9479	det	the,ability
R6510	T9479	T9477	pobj	ability,on
R6511	T9480	T9481	aux	to,specify
R6512	T9481	T9479	acl	specify,ability
R6513	T9482	T9483	amod	alternative,fates
R6514	T9483	T9481	dobj	fates,specify
R6515	T9484	T9481	prep	for,specify
R6516	T9485	T9486	det	an,group
R6517	T9486	T9484	pobj	group,for
R6518	T9487	T9486	amod	undifferentiated,group
R6519	T9488	T9486	prep	of,group
R6520	T9489	T9490	compound	precursor,cells
R6521	T9490	T9488	pobj	cells,of
R6522	T9491	T9476	cc	and,focused
R6523	T9492	T9493	nsubj	another,focused
R6524	T9493	T9476	conj	focused,focused
R6525	T9494	T9493	prep	on,focused
R6526	T9495	T9496	det	the,ability
R6527	T9496	T9494	pobj	ability,on
R6528	T9497	T9498	aux	to,support
R6529	T9498	T9496	acl	support,ability
R6530	T9499	T9500	amod	proliferative,expansion
R6531	T9500	T9498	dobj	expansion,support
R6532	T9501	T9500	prep	of,expansion
R6533	T9502	T9503	det	a,population
R6534	T9503	T9501	pobj	population,of
R6535	T9504	T9503	compound	cell,population
R6536	T9505	T9506	poss	whose,fate
R6537	T9506	T9507	dep	fate,determined
R6538	T9507	T9503	relcl	determined,population
R6539	T9508	T9507	auxpass	is,determined
R6540	T9509	T9507	advmod	already,determined
R6541	T9510	T9511	punct	(,reviewed
R6542	T9511	T9493	parataxis	reviewed,focused
R6543	T9512	T9511	prep	in,reviewed
R6544	T9513	T9512	pobj	Tada,in
R6545	T9514	T9513	cc	and,Tada
R6546	T9515	T9513	conj	Smith,Tada
R6547	T9516	T9513	npadvmod	2001,Tada
R6548	T9517	T9511	punct	),reviewed
R6549	T9518	T9455	punct	.,emerged
R6550	T9520	T9521	det	Either,mechanism
R6551	T9521	T9522	nsubj	mechanism,apply
R6552	T9523	T9522	aux	may,apply
R6553	T9524	T9522	prep	to,apply
R6554	T9525	T9526	det	the,transformation
R6555	T9526	T9524	pobj	transformation,to
R6556	T9527	T9526	amod	apparent,transformation
R6557	T9528	T9526	amod	dorsal,transformation
R6558	T9529	T9528	punct	-,dorsal
R6559	T9530	T9528	prep	to,dorsal
R6560	T9531	T9530	punct	-,to
R6561	T9532	T9530	amod	ventral,to
R6562	T9533	T9526	prep	in,transformation
R6563	T9534	T9535	compound	deH,deH
R6564	T9535	T9537	compound	deH,mice
R6565	T9536	T9535	punct	/,deH
R6566	T9537	T9533	pobj	mice,in
R6567	T9538	T9522	punct	.,apply
R6568	T9540	T9541	prep	For,be
R6569	T9542	T9540	pobj	example,For
R6570	T9543	T9541	punct	", ",be
R6571	T9544	T9545	mark	while,traced
R6572	T9545	T9541	advcl	traced,be
R6573	T9546	T9547	det	the,domain
R6574	T9547	T9545	nsubjpass	domain,traced
R6575	T9548	T9547	amod	expanded,domain
R6576	T9549	T9547	prep	of,domain
R6577	T9550	T9551	compound	Agouti,expression
R6578	T9551	T9549	pobj	expression,of
R6579	T9552	T9547	prep	in,domain
R6580	T9553	T9554	amod	postnatal,animals
R6581	T9554	T9552	pobj	animals,in
R6582	T9555	T9556	compound	deH,deH
R6583	T9556	T9554	compound	deH,animals
R6584	T9557	T9556	punct	/,deH
R6585	T9558	T9545	aux	can,traced
R6586	T9559	T9545	auxpass	be,traced
R6587	T9560	T9545	prep	to,traced
R6588	T9561	T9560	pobj	events,to
R6589	T9562	T9563	dep	that,occur
R6590	T9563	T9561	relcl	occur,events
R6591	T9564	T9563	prep	between,occur
R6592	T9565	T9564	pobj	E11.5,between
R6593	T9566	T9565	cc	and,E11.5
R6594	T9567	T9565	conj	E13.5,E11.5
R6595	T9568	T9541	punct	", ",be
R6596	T9569	T9570	det	the,cause
R6597	T9570	T9541	nsubj	cause,be
R6598	T9571	T9570	amod	underlying,cause
R6599	T9572	T9541	aux	may,be
R6600	T9573	T9574	mark	that,acquire
R6601	T9574	T9541	advcl	acquire,be
R6602	T9575	T9576	amod	embryonic,cells
R6603	T9576	T9574	nsubj	cells,acquire
R6604	T9577	T9576	prep	in,cells
R6605	T9578	T9579	amod	dorsolateral,mesenchyme
R6606	T9579	T9577	pobj	mesenchyme,in
R6607	T9580	T9581	det	a,identity
R6608	T9581	T9574	dobj	identity,acquire
R6609	T9582	T9581	amod	ventral,identity
R6610	T9583	T9582	cc	rather,ventral
R6611	T9584	T9583	dep	than,rather
R6612	T9585	T9582	conj	dorsal,ventral
R6613	T9586	T9574	cc	or,acquire
R6614	T9587	T9588	mark	that,fail
R6615	T9588	T9574	conj	fail,acquire
R6616	T9589	T9590	det	those,cells
R6617	T9590	T9588	nsubj	cells,fail
R6618	T9591	T9592	aux	to,proliferate
R6619	T9592	T9588	xcomp	proliferate,fail
R6620	T9593	T9592	advmod	normally,proliferate
R6621	T9594	T9588	punct	", ",fail
R6622	T9595	T9588	advcl	followed,fail
R6623	T9596	T9595	agent	by,followed
R6624	T9597	T9598	amod	compensatory,expansion
R6625	T9598	T9596	pobj	expansion,by
R6626	T9599	T9598	prep	of,expansion
R6627	T9600	T9601	amod	ventral,cells
R6628	T9601	T9599	pobj	cells,of
R6629	T9602	T9541	punct	.,be
R6630	T9604	T9605	compound	Cell,lineage
R6631	T9605	T9606	compound	lineage,studies
R6632	T9606	T9607	nsubj	studies,provide
R6633	T9608	T9607	aux	should,provide
R6634	T9609	T9610	det	a,answer
R6635	T9610	T9607	dobj	answer,provide
R6636	T9611	T9610	amod	definitive,answer
R6637	T9612	T9607	punct	", ",provide
R6638	T9613	T9607	cc	but,provide
R6639	T9614	T9615	nsubj	we,favor
R6640	T9615	T9607	conj	favor,provide
R6641	T9616	T9617	det	the,hypothesis
R6642	T9617	T9615	dobj	hypothesis,favor
R6643	T9618	T9617	amod	latter,hypothesis
R6644	T9619	T9615	punct	", ",favor
R6645	T9620	T9621	mark	because,revealed
R6646	T9621	T9615	advcl	revealed,favor
R6647	T9622	T9621	nsubj	measurements,revealed
R6648	T9623	T9622	prep	of,measurements
R6649	T9624	T9625	amod	dorsoventral,regions
R6650	T9625	T9623	pobj	regions,of
R6651	T9626	T9622	prep	according,measurements
R6652	T9627	T9626	prep	to,according
R6653	T9628	T9629	compound	hair,color
R6654	T9629	T9627	pobj	color,to
R6655	T9630	T9629	prep	in,color
R6656	T9631	T9632	compound	deH,deH
R6657	T9632	T9634	compound	deH,mice
R6658	T9633	T9632	punct	/,deH
R6659	T9634	T9630	pobj	mice,in
R6660	T9635	T9636	det	a,increase
R6661	T9636	T9621	dobj	increase,revealed
R6662	T9637	T9636	amod	small,increase
R6663	T9638	T9636	prep	of,increase
R6664	T9639	T9640	det	the,region
R6665	T9640	T9638	pobj	region,of
R6666	T9641	T9642	amod	cream,colored
R6667	T9642	T9640	amod	colored,region
R6668	T9643	T9642	punct	-,colored
R6669	T9644	T9640	amod	ventral,region
R6670	T9645	T9621	prep	in,revealed
R6671	T9646	T9645	pobj	addition,in
R6672	T9647	T9646	prep	to,addition
R6673	T9648	T9649	det	the,doubling
R6674	T9649	T9647	pobj	doubling,to
R6675	T9650	T9649	amod	approximate,doubling
R6676	T9651	T9649	prep	of,doubling
R6677	T9652	T9653	det	the,region
R6678	T9653	T9651	pobj	region,of
R6679	T9654	T9653	amod	yellow,region
R6680	T9655	T9653	compound	flank,region
R6681	T9656	T9657	punct	(,see
R6682	T9657	T9621	parataxis	see,revealed
R6683	T9658	T9657	dobj	Figure,see
R6684	T9659	T9658	nummod	2,Figure
R6685	T9660	T9657	punct	),see
R6686	T9661	T9615	punct	.,favor
R6687	T9663	T9664	prep	In,are
R6688	T9665	T9666	amod	embryonic,mesenchyme
R6689	T9666	T9663	pobj	mesenchyme,In
R6690	T9667	T9664	punct	", ",are
R6691	T9668	T9664	nsubj	expression,are
R6692	T9669	T9668	prep	of,expression
R6693	T9670	T9669	pobj	Tbx15,of
R6694	T9671	T9670	cc	and,Tbx15
R6695	T9672	T9670	conj	Agouti,Tbx15
R6696	T9673	T9664	acomp	complementary,are
R6697	T9674	T9664	punct	", ",are
R6698	T9675	T9664	cc	and,are
R6699	T9676	T9677	nsubj	it,is
R6700	T9677	T9664	conj	is,are
R6701	T9678	T9677	acomp	possible,is
R6702	T9679	T9680	mark	that,acts
R6703	T9680	T9677	ccomp	acts,is
R6704	T9681	T9680	nsubj	Tbx15,acts
R6705	T9682	T9680	advmod	directly,acts
R6706	T9683	T9684	aux	to,inhibit
R6707	T9684	T9680	advcl	inhibit,acts
R6708	T9685	T9686	compound	Agouti,transcription
R6709	T9686	T9684	dobj	transcription,inhibit
R6710	T9687	T9684	prep	in,inhibit
R6711	T9688	T9689	amod	dorsolateral,mesenchyme
R6712	T9689	T9687	pobj	mesenchyme,in
R6713	T9690	T9664	punct	.,are
R6714	T9692	T9693	advmod	However,is
R6715	T9694	T9693	punct	", ",is
R6716	T9695	T9696	det	the,ability
R6717	T9696	T9693	nsubj	ability,is
R6718	T9697	T9696	prep	of,ability
R6719	T9698	T9697	pobj	Tbx15,of
R6720	T9699	T9700	aux	to,suppress
R6721	T9700	T9696	acl	suppress,ability
R6722	T9701	T9700	dobj	expression,suppress
R6723	T9702	T9701	prep	of,expression
R6724	T9703	T9704	det	the,isoform
R6725	T9704	T9702	pobj	isoform,of
R6726	T9705	T9706	amod	ventral,specific
R6727	T9706	T9704	amod	specific,isoform
R6728	T9707	T9706	punct	-,specific
R6729	T9708	T9704	compound	Agouti,isoform
R6730	T9709	T9700	prep	in,suppress
R6731	T9710	T9711	amod	postnatal,mice
R6732	T9711	T9709	pobj	mice,in
R6733	T9712	T9693	acomp	likely,is
R6734	T9713	T9714	aux	to,be
R6735	T9714	T9712	xcomp	be,likely
R6736	T9715	T9714	acomp	indirect,be
R6737	T9716	T9693	punct	", ",is
R6738	T9717	T9718	mark	since,occurs
R6739	T9718	T9693	advcl	occurs,is
R6740	T9719	T9720	amod	postnatal,expression
R6741	T9720	T9718	nsubj	expression,occurs
R6742	T9721	T9720	prep	of,expression
R6743	T9722	T9721	pobj	Tbx15,of
R6744	T9723	T9718	advmod	broadly,occurs
R6745	T9724	T9718	prep	along,occurs
R6746	T9725	T9726	det	the,axis
R6747	T9726	T9724	pobj	axis,along
R6748	T9727	T9726	amod	dorsoventral,axis
R6749	T9728	T9718	cc	and,occurs
R6750	T9729	T9718	conj	overlaps,occurs
R6751	T9730	T9729	advmod	extensively,overlaps
R6752	T9731	T9729	prep	with,overlaps
R6753	T9732	T9731	pobj	that,with
R6754	T9733	T9732	prep	of,that
R6755	T9734	T9733	pobj	Agouti,of
R6756	T9735	T9693	punct	.,is
R6757	T9737	T9738	prep	In,include
R6758	T9739	T9740	det	either,case
R6759	T9740	T9737	pobj	case,In
R6760	T9741	T9738	punct	", ",include
R6761	T9742	T9743	det	the,targets
R6762	T9743	T9738	nsubj	targets,include
R6763	T9744	T9743	prep	of,targets
R6764	T9745	T9746	compound	Tbx15,action
R6765	T9746	T9744	pobj	action,of
R6766	T9747	T9743	prep	in,targets
R6767	T9748	T9749	det	the,skin
R6768	T9749	T9747	pobj	skin,in
R6769	T9750	T9738	dobj	genes,include
R6770	T9751	T9738	prep	in,include
R6771	T9752	T9751	pobj	addition,in
R6772	T9753	T9752	prep	to,addition
R6773	T9754	T9753	pobj	Agouti,to
R6774	T9755	T9738	punct	", ",include
R6775	T9756	T9757	mark	since,exhibit
R6776	T9757	T9738	advcl	exhibit,include
R6777	T9758	T9759	compound	hair,length
R6778	T9759	T9757	nsubj	length,exhibit
R6779	T9760	T9759	cc	and,length
R6780	T9761	T9762	compound	melanocyte,distribution
R6781	T9762	T9759	conj	distribution,length
R6782	T9763	T9764	det	a,alteration
R6783	T9764	T9757	dobj	alteration,exhibit
R6784	T9765	T9764	amod	demonstrable,alteration
R6785	T9766	T9765	punct	", ",demonstrable
R6786	T9767	T9765	cc	albeit,demonstrable
R6787	T9768	T9765	conj	subtle,demonstrable
R6788	T9769	T9764	punct	", ",alteration
R6789	T9770	T9757	prep	in,exhibit
R6790	T9771	T9770	pobj	animals,in
R6791	T9772	T9773	dep	that,carry
R6792	T9773	T9771	relcl	carry,animals
R6793	T9774	T9775	det	a,allele
R6794	T9775	T9773	dobj	allele,carry
R6795	T9776	T9775	amod	null,allele
R6796	T9777	T9775	compound	Agouti,allele
R6797	T9778	T9738	punct	.,include
R6798	T9780	T9781	nummod	One,target
R6799	T9781	T9783	nsubj	target,is
R6800	T9782	T9781	amod	potential,target
R6801	T9784	T9783	attr	Alx4,is
R6802	T9785	T9784	punct	", ",Alx4
R6803	T9786	T9787	dep	which,expressed
R6804	T9787	T9784	relcl	expressed,Alx4
R6805	T9788	T9787	punct	", ",expressed
R6806	T9789	T9787	prep	like,expressed
R6807	T9790	T9789	pobj	Agouti,like
R6808	T9791	T9787	punct	", ",expressed
R6809	T9792	T9787	auxpass	is,expressed
R6810	T9793	T9787	prep	in,expressed
R6811	T9794	T9795	amod	ventral,mesenchyme
R6812	T9795	T9793	pobj	mesenchyme,in
R6813	T9796	T9795	amod	embryonic,mesenchyme
R6814	T9797	T9787	punct	", ",expressed
R6815	T9798	T9787	cc	and,expressed
R6816	T9799	T9787	punct	", ",expressed
R6817	T9800	T9801	advmod	when,mutated
R6818	T9801	T9802	advcl	mutated,affects
R6819	T9802	T9787	conj	affects,expressed
R6820	T9803	T9802	punct	", ",affects
R6821	T9804	T9805	nmod	hair,follicle
R6822	T9805	T9807	nmod	follicle,development
R6823	T9806	T9805	punct	-,follicle
R6824	T9807	T9802	dobj	development,affects
R6825	T9808	T9809	advmod	as,as
R6826	T9809	T9805	cc	as,follicle
R6827	T9810	T9809	advmod	well,as
R6828	T9811	T9805	conj	limb,follicle
R6829	T9812	T9811	cc	and,limb
R6830	T9813	T9811	conj	craniofacial,limb
R6831	T9814	T9815	punct	(,Qu
R6832	T9815	T9783	meta	Qu,is
R6833	T9816	T9815	nmod	et,Qu
R6834	T9817	T9815	nmod	al.,Qu
R6835	T9818	T9815	nummod	1997,Qu
R6836	T9819	T9815	punct	", ",Qu
R6837	T9820	T9815	nummod	1998,Qu
R6838	T9821	T9815	punct	;,Qu
R6839	T9822	T9815	nmod	Wu,Qu
R6840	T9823	T9815	nmod	et,Qu
R6841	T9824	T9815	nmod	al.,Qu
R6842	T9825	T9815	nummod	2000,Qu
R6843	T9826	T9815	punct	;,Qu
R6844	T9827	T9815	nmod	Wuyts,Qu
R6845	T9828	T9815	nmod	et,Qu
R6846	T9829	T9815	nmod	al.,Qu
R6847	T9830	T9815	nummod	2000,Qu
R6848	T9831	T9815	punct	;,Qu
R6849	T9832	T9815	nmod	Mavrogiannis,Qu
R6850	T9833	T9815	nmod	et,Qu
R6851	T9834	T9815	nmod	al.,Qu
R6852	T9835	T9815	nummod	2001,Qu
R6853	T9836	T9815	punct	),Qu
R6854	T9837	T9783	punct	.,is
R6855	T9839	T9840	advmod	However,appears
R6856	T9841	T9840	punct	", ",appears
R6857	T9842	T9840	nsubj	expression,appears
R6858	T9843	T9842	prep	of,expression
R6859	T9844	T9845	amod	ventral,markers
R6860	T9845	T9843	pobj	markers,of
R6861	T9846	T9847	amod	such,as
R6862	T9847	T9845	prep	as,markers
R6863	T9848	T9847	pobj	Alx4,as
R6864	T9849	T9848	punct	", ",Alx4
R6865	T9850	T9851	advmod	as,as
R6866	T9851	T9848	cc	as,Alx4
R6867	T9852	T9851	advmod	well,as
R6868	T9853	T9848	conj	Alx3,Alx4
R6869	T9854	T9853	cc	and,Alx3
R6870	T9855	T9853	conj	Msx2,Alx3
R6871	T9856	T9840	punct	", ",appears
R6872	T9857	T9858	aux	to,be
R6873	T9858	T9840	xcomp	be,appears
R6874	T9859	T9858	acomp	unaffected,be
R6875	T9860	T9858	prep	at,be
R6876	T9861	T9860	pobj	E11.5,at
R6877	T9862	T9858	prep	in,be
R6878	T9863	T9864	compound	deH,deH
R6879	T9864	T9866	compound	deH,embryos
R6880	T9865	T9864	punct	/,deH
R6881	T9866	T9862	pobj	embryos,in
R6882	T9867	T9868	punct	(,shown
R6883	T9868	T9858	parataxis	shown,be
R6884	T9869	T9868	nsubj	data,shown
R6885	T9870	T9868	neg	not,shown
R6886	T9871	T9868	punct	),shown
R6887	T9872	T9840	punct	.,appears
R6896	T10220	T10219	cc	and,Differences
R6897	T10221	T10219	conj	Similarities,Differences
R6898	T10222	T10219	prep	to,Differences
R6899	T10223	T10224	amod	Dorsoventral,Patterning
R6900	T10224	T10222	pobj	Patterning,to
R6901	T10225	T10224	compound	Limb,Patterning
R6902	T10227	T10228	nsubj	Loss,affects
R6903	T10229	T10227	prep	of,Loss
R6904	T10230	T10229	pobj	Tbx15,of
R6905	T10231	T10228	advmod	also,affects
R6906	T10232	T10233	amod	regional,distribution
R6907	T10233	T10228	dobj	distribution,affects
R6908	T10234	T10233	prep	of,distribution
R6909	T10235	T10236	compound	hair,color
R6910	T10236	T10234	pobj	color,of
R6911	T10237	T10233	prep	in,distribution
R6912	T10238	T10239	det	the,limbs
R6913	T10239	T10237	pobj	limbs,in
R6914	T10240	T10228	punct	", ",affects
R6915	T10241	T10228	prep	with,affects
R6916	T10242	T10243	nsubj	areas,giving
R6917	T10243	T10241	pcomp	giving,with
R6918	T10244	T10245	dep	that,produce
R6919	T10245	T10242	relcl	produce,areas
R6920	T10246	T10245	aux	would,produce
R6921	T10247	T10245	advmod	normally,produce
R6922	T10248	T10249	amod	black,hair
R6923	T10249	T10245	dobj	hair,produce
R6924	T10250	T10243	dobj	rise,giving
R6925	T10251	T10243	prep	to,giving
R6926	T10252	T10253	amod	yellow,hair
R6927	T10253	T10251	pobj	hair,to
R6928	T10254	T10243	advmod	instead,giving
R6929	T10255	T10228	punct	.,affects
R6930	T10257	T10258	advmod	However,correspond
R6931	T10259	T10258	punct	", ",correspond
R6932	T10260	T10261	preconj	neither,patterns
R6933	T10261	T10258	nsubj	patterns,correspond
R6934	T10262	T10261	amod	normal,patterns
R6935	T10263	T10261	prep	of,patterns
R6936	T10264	T10265	amod	pigment,type
R6937	T10265	T10267	compound	type,synthesis
R6938	T10266	T10265	punct	-,type
R6939	T10267	T10263	pobj	synthesis,of
R6940	T10268	T10261	prep	in,patterns
R6941	T10269	T10270	det	the,limb
R6942	T10270	T10268	pobj	limb,in
R6943	T10271	T10261	cc	nor,patterns
R6944	T10272	T10273	poss	their,disruption
R6945	T10273	T10261	conj	disruption,patterns
R6946	T10274	T10273	prep	in,disruption
R6947	T10275	T10276	compound	deH,deH
R6948	T10276	T10278	compound	deH,mice
R6949	T10277	T10276	punct	/,deH
R6950	T10278	T10274	pobj	mice,in
R6951	T10279	T10258	prep	to,correspond
R6952	T10280	T10281	amod	obvious,compartments
R6953	T10281	T10279	pobj	compartments,to
R6954	T10282	T10281	amod	developmental,compartments
R6955	T10283	T10258	punct	.,correspond
R6956	T10285	T10286	advmod	Furthermore,have
R6957	T10287	T10286	punct	", ",have
R6958	T10288	T10286	nsubj	losses,have
R6959	T10289	T10288	prep	of,losses
R6960	T10290	T10289	pobj	function,of
R6961	T10291	T10288	prep	for,losses
R6962	T10292	T10291	pobj	En1,for
R6963	T10293	T10292	cc	or,En1
R6964	T10294	T10292	conj	Wnt7a,En1
R6965	T10295	T10288	punct	", ",losses
R6966	T10296	T10297	dep	which,cause
R6967	T10297	T10288	relcl	cause,losses
R6968	T10298	T10299	det	a,transformation
R6969	T10299	T10297	dobj	transformation,cause
R6970	T10300	T10299	amod	partial,transformation
R6971	T10301	T10299	prep	of,transformation
R6972	T10302	T10303	det	the,limb
R6973	T10303	T10301	pobj	limb,of
R6974	T10304	T10303	amod	distal,limb
R6975	T10305	T10299	prep	from,transformation
R6976	T10306	T10305	pobj	dorsum,from
R6977	T10307	T10305	prep	to,from
R6978	T10308	T10307	pobj	ventrum,to
R6979	T10309	T10310	punct	(,Loomis
R6980	T10310	T10305	meta	Loomis,from
R6981	T10311	T10310	nmod	et,Loomis
R6982	T10312	T10310	nmod	al.,Loomis
R6983	T10313	T10310	nummod	1996,Loomis
R6984	T10314	T10310	punct	),Loomis
R6985	T10315	T10305	cc	or,from
R6986	T10316	T10317	npadvmod	ventrum,to
R6987	T10317	T10305	conj	to,from
R6988	T10318	T10317	pobj	dorsum,to
R6989	T10319	T10320	punct	(,Parr
R6990	T10320	T10317	meta	Parr,to
R6991	T10321	T10320	cc	and,Parr
R6992	T10322	T10320	conj	McMahon,Parr
R6993	T10323	T10322	nummod	1995,McMahon
R6994	T10324	T10322	punct	),McMahon
R6995	T10325	T10297	punct	", ",cause
R6996	T10326	T10297	advmod	respectively,cause
R6997	T10327	T10286	punct	", ",have
R6998	T10328	T10329	det	no,effect
R6999	T10329	T10286	dobj	effect,have
R7000	T10330	T10329	prep	on,effect
R7001	T10331	T10332	amod	regional,patterns
R7002	T10332	T10330	pobj	patterns,on
R7003	T10333	T10332	prep	of,patterns
R7004	T10334	T10335	compound	Agouti,expression
R7005	T10335	T10333	pobj	expression,of
R7006	T10336	T10332	cc	or,patterns
R7007	T10337	T10332	conj	distribution,patterns
R7008	T10338	T10337	prep	of,distribution
R7009	T10339	T10340	compound	hair,color
R7010	T10340	T10342	compound	color,regions
R7011	T10341	T10340	punct	-,color
R7012	T10342	T10338	pobj	regions,of
R7013	T10343	T10344	punct	(,Y.
R7014	T10344	T10286	meta	Y.,have
R7015	T10345	T10344	nmod	Chen,Y.
R7016	T10346	T10344	punct	", ",Y.
R7017	T10347	T10344	amod	unpublished,Y.
R7018	T10348	T10344	nmod	data,Y.
R7019	T10349	T10344	punct	),Y.
R7020	T10350	T10286	punct	.,have
R7021	T10352	T10353	punct	(,is
R7022	T10354	T10355	amod	Ectopic,pigmentation
R7023	T10355	T10353	nsubj	pigmentation,is
R7024	T10356	T10355	prep	of,pigmentation
R7025	T10357	T10358	det	the,footpads
R7026	T10358	T10356	pobj	footpads,of
R7027	T10359	T10358	amod	ventral,footpads
R7028	T10360	T10361	dep	that,develops
R7029	T10361	T10355	relcl	develops,pigmentation
R7030	T10362	T10361	prep	in,develops
R7031	T10363	T10364	compound	En1,mice
R7032	T10364	T10362	pobj	mice,in
R7033	T10365	T10364	compound	mutant,mice
R7034	T10366	T10353	acomp	unrelated,is
R7035	T10367	T10366	prep	to,unrelated
R7036	T10368	T10369	compound	pigment,type
R7037	T10369	T10371	compound	type,synthesis
R7038	T10370	T10369	punct	-,type
R7039	T10371	T10367	pobj	synthesis,to
R7040	T10372	T10353	cc	and,is
R7041	T10373	T10374	advmod	instead,reflects
R7042	T10374	T10353	conj	reflects,is
R7043	T10375	T10374	advmod	likely,reflects
R7044	T10376	T10377	det	a,requirement
R7045	T10377	T10374	dobj	requirement,reflects
R7046	T10378	T10377	prep	for,requirement
R7047	T10379	T10378	pobj	En1,for
R7048	T10380	T10377	punct	", ",requirement
R7049	T10381	T10377	amod	independent,requirement
R7050	T10382	T10381	prep	of,independent
R7051	T10383	T10382	pobj	Wnt7a,of
R7052	T10384	T10377	punct	", ",requirement
R7053	T10385	T10386	aux	to,repress
R7054	T10386	T10377	acl	repress,requirement
R7055	T10387	T10386	dobj	migration,repress
R7056	T10388	T10387	cc	or,migration
R7057	T10389	T10387	conj	proliferation,migration
R7058	T10390	T10387	punct	(,migration
R7059	T10391	T10387	cc	or,migration
R7060	T10392	T10387	conj	both,migration
R7061	T10393	T10392	punct	),both
R7062	T10394	T10387	prep	of,migration
R7063	T10395	T10396	compound	pigment,cells
R7064	T10396	T10394	pobj	cells,of
R7065	T10397	T10387	prep	in,migration
R7066	T10398	T10399	amod	ventral,epidermis
R7067	T10399	T10397	pobj	epidermis,in
R7068	T10400	T10401	punct	[,Cygan
R7069	T10401	T10374	meta	Cygan,reflects
R7070	T10402	T10401	nmod	et,Cygan
R7071	T10403	T10401	nmod	al.,Cygan
R7072	T10404	T10401	nummod	1997,Cygan
R7073	T10405	T10401	punct	;,Cygan
R7074	T10406	T10401	nmod	Loomis,Cygan
R7075	T10407	T10401	nmod	et,Cygan
R7076	T10408	T10401	nmod	al.,Cygan
R7077	T10409	T10401	nummod	1998,Cygan
R7078	T10410	T10401	punct	],Cygan
R7079	T10411	T10353	punct	.,is
R7080	T10412	T10353	punct	),is
R7081	T10414	T10415	det	These,considerations
R7082	T10415	T10416	nsubj	considerations,notwithstanding
R7083	T10416	T10417	advcl	notwithstanding,shares
R7084	T10418	T10417	punct	", ",shares
R7085	T10419	T10417	nsubj	control,shares
R7086	T10420	T10419	prep	of,control
R7087	T10421	T10422	amod	dorsoventral,pattern
R7088	T10422	T10420	pobj	pattern,of
R7089	T10423	T10422	compound	trunk,pattern
R7090	T10424	T10419	prep	by,control
R7091	T10425	T10424	pobj	Tbx15,by
R7092	T10426	T10427	amod	certain,features
R7093	T10427	T10417	dobj	features,shares
R7094	T10428	T10417	prep	with,shares
R7095	T10429	T10428	pobj	control,with
R7096	T10430	T10429	prep	of,control
R7097	T10431	T10432	amod	dorsoventral,patterning
R7098	T10432	T10430	pobj	patterning,of
R7099	T10433	T10432	compound	limb,patterning
R7100	T10434	T10429	prep	by,control
R7101	T10435	T10434	pobj	Lmx1b,by
R7102	T10436	T10435	punct	", ",Lmx1b
R7103	T10437	T10438	det	a,factor
R7104	T10438	T10435	appos	factor,Lmx1b
R7105	T10439	T10440	compound	LIM,domain
R7106	T10440	T10438	compound	domain,factor
R7107	T10441	T10438	compound	transcription,factor
R7108	T10442	T10443	dep	that,acts
R7109	T10443	T10438	relcl	acts,factor
R7110	T10444	T10443	advmod	downstream,acts
R7111	T10445	T10444	prep	of,downstream
R7112	T10446	T10445	pobj	Wnt7a,of
R7113	T10447	T10446	cc	and,Wnt7a
R7114	T10448	T10446	conj	En1,Wnt7a
R7115	T10449	T10450	punct	(,Riddle
R7116	T10450	T10429	meta	Riddle,control
R7117	T10451	T10450	nmod	et,Riddle
R7118	T10452	T10450	nmod	al.,Riddle
R7119	T10453	T10450	nummod	1995,Riddle
R7120	T10454	T10450	punct	;,Riddle
R7121	T10455	T10450	conj	Vogel,Riddle
R7122	T10456	T10455	nmod	et,Vogel
R7123	T10457	T10455	nmod	al.,Vogel
R7124	T10458	T10455	nummod	1995,Vogel
R7125	T10459	T10455	punct	;,Vogel
R7126	T10460	T10455	conj	Cygan,Vogel
R7127	T10461	T10460	nmod	et,Cygan
R7128	T10462	T10460	nmod	al.,Cygan
R7129	T10463	T10460	nummod	1997,Cygan
R7130	T10464	T10460	punct	;,Cygan
R7131	T10465	T10460	conj	Logan,Cygan
R7132	T10466	T10465	nmod	et,Logan
R7133	T10467	T10465	nmod	al.,Logan
R7134	T10468	T10465	nummod	1997,Logan
R7135	T10469	T10465	punct	;,Logan
R7136	T10470	T10465	conj	Loomis,Logan
R7137	T10471	T10470	nmod	et,Loomis
R7138	T10472	T10470	nmod	al.,Loomis
R7139	T10473	T10470	nummod	1998,Loomis
R7140	T10474	T10470	punct	;,Loomis
R7141	T10475	T10470	conj	Chen,Loomis
R7142	T10476	T10475	cc	and,Chen
R7143	T10477	T10475	conj	Johnson,Chen
R7144	T10478	T10477	nummod	2002,Johnson
R7145	T10479	T10477	punct	),Johnson
R7146	T10480	T10417	punct	.,shares
R7147	T10482	T10483	preconj	Both,Tbx15
R7148	T10483	T10484	nsubj	Tbx15,act
R7149	T10485	T10483	cc	and,Tbx15
R7150	T10486	T10483	conj	Lmx1b,Tbx15
R7151	T10487	T10484	advmod	autonomously,act
R7152	T10488	T10484	prep	in,act
R7153	T10489	T10490	amod	mesenchymal,cells
R7154	T10490	T10488	pobj	cells,in
R7155	T10491	T10492	aux	to,promote
R7156	T10492	T10484	advcl	promote,act
R7157	T10493	T10494	det	a,identity
R7158	T10494	T10492	dobj	identity,promote
R7159	T10495	T10494	amod	dorsal,identity
R7160	T10496	T10484	punct	", ",act
R7161	T10497	T10484	cc	yet,act
R7162	T10498	T10484	conj	have,act
R7163	T10499	T10500	compound	expression,domains
R7164	T10500	T10498	dobj	domains,have
R7165	T10501	T10502	dep	that,correspond
R7166	T10502	T10500	relcl	correspond,domains
R7167	T10503	T10502	aux	do,correspond
R7168	T10504	T10502	neg	not,correspond
R7169	T10505	T10502	prep	to,correspond
R7170	T10506	T10507	compound	cell,lineage
R7171	T10507	T10508	compound	lineage,compartments
R7172	T10508	T10505	pobj	compartments,to
R7173	T10509	T10502	prep	in,correspond
R7174	T10510	T10511	det	the,flank
R7175	T10511	T10509	pobj	flank,in
R7176	T10512	T10513	punct	(,Tbx15
R7177	T10513	T10511	parataxis	Tbx15,flank
R7178	T10514	T10513	punct	),Tbx15
R7179	T10515	T10511	cc	or,flank
R7180	T10516	T10517	det	the,limb
R7181	T10517	T10511	conj	limb,flank
R7182	T10518	T10519	punct	(,Lmx1b
R7183	T10519	T10517	parataxis	Lmx1b,limb
R7184	T10520	T10519	punct	),Lmx1b
R7185	T10521	T10522	punct	(,Altabef
R7186	T10522	T10498	meta	Altabef,have
R7187	T10523	T10522	nmod	et,Altabef
R7188	T10524	T10522	nmod	al.,Altabef
R7189	T10525	T10522	nummod	1997,Altabef
R7190	T10526	T10522	punct	;,Altabef
R7191	T10527	T10522	nmod	Michaud,Altabef
R7192	T10528	T10522	nmod	et,Altabef
R7193	T10529	T10522	nmod	al.,Altabef
R7194	T10530	T10522	nummod	1997,Altabef
R7195	T10531	T10522	punct	),Altabef
R7196	T10532	T10484	punct	.,act
R7197	T10534	T10535	prep	In,depends
R7198	T10536	T10537	det	the,case
R7199	T10537	T10534	pobj	case,In
R7200	T10538	T10537	prep	of,case
R7201	T10539	T10538	pobj	Lmx1b,of
R7202	T10540	T10535	punct	", ",depends
R7203	T10541	T10542	poss	its,expression
R7204	T10542	T10535	nsubj	expression,depends
R7205	T10543	T10542	prep	in,expression
R7206	T10544	T10545	det	the,limb
R7207	T10545	T10543	pobj	limb,in
R7208	T10546	T10545	amod	distal,limb
R7209	T10547	T10535	prep	on,depends
R7210	T10548	T10547	pobj	Wnt7a,on
R7211	T10549	T10548	acl	produced,Wnt7a
R7212	T10550	T10549	prep	in,produced
R7213	T10551	T10552	det	the,ectoderm
R7214	T10552	T10550	pobj	ectoderm,in
R7215	T10553	T10552	amod	overlying,ectoderm
R7216	T10554	T10552	amod	dorsal,ectoderm
R7217	T10555	T10556	punct	(,Riddle
R7218	T10556	T10535	meta	Riddle,depends
R7219	T10557	T10556	nmod	et,Riddle
R7220	T10558	T10556	nmod	al.,Riddle
R7221	T10559	T10556	nummod	1995,Riddle
R7222	T10560	T10556	punct	;,Riddle
R7223	T10561	T10556	nmod	Cygan,Riddle
R7224	T10562	T10556	nmod	et,Riddle
R7225	T10563	T10556	nmod	al.,Riddle
R7226	T10564	T10556	nummod	1997,Riddle
R7227	T10565	T10556	punct	;,Riddle
R7228	T10566	T10556	nmod	Loomis,Riddle
R7229	T10567	T10556	nmod	et,Riddle
R7230	T10568	T10556	nmod	al.,Riddle
R7231	T10569	T10556	nummod	1998,Riddle
R7232	T10570	T10556	punct	),Riddle
R7233	T10571	T10535	punct	.,depends
R7234	T10573	T10574	nsubjpass	Wnt7a,restricted
R7235	T10575	T10574	punct	", ",restricted
R7236	T10576	T10574	prep	in,restricted
R7237	T10577	T10576	pobj	turn,in
R7238	T10578	T10574	punct	", ",restricted
R7239	T10579	T10574	auxpass	is,restricted
R7240	T10580	T10574	prep	to,restricted
R7241	T10581	T10582	amod	dorsal,ectoderm
R7242	T10582	T10580	pobj	ectoderm,to
R7243	T10583	T10574	agent	by,restricted
R7244	T10584	T10583	pobj	En1,by
R7245	T10585	T10574	prep	in,restricted
R7246	T10586	T10587	det	the,ectoderm
R7247	T10587	T10585	pobj	ectoderm,in
R7248	T10588	T10587	amod	ventral,ectoderm
R7249	T10589	T10590	punct	(,Loomis
R7250	T10590	T10574	meta	Loomis,restricted
R7251	T10591	T10590	nmod	et,Loomis
R7252	T10592	T10590	nmod	al.,Loomis
R7253	T10593	T10590	nummod	1996,Loomis
R7254	T10594	T10590	punct	;,Loomis
R7255	T10595	T10590	nmod	Cygan,Loomis
R7256	T10596	T10590	nmod	et,Loomis
R7257	T10597	T10590	nmod	al.,Loomis
R7258	T10598	T10590	nummod	1997,Loomis
R7259	T10599	T10590	punct	;,Loomis
R7260	T10600	T10590	nmod	Logan,Loomis
R7261	T10601	T10590	nmod	et,Loomis
R7262	T10602	T10590	nmod	al.,Loomis
R7263	T10603	T10590	nummod	1997,Loomis
R7264	T10604	T10590	punct	),Loomis
R7265	T10605	T10574	punct	", ",restricted
R7266	T10606	T10607	poss	whose,expression
R7267	T10607	T10608	dep	expression,marks
R7268	T10608	T10574	ccomp	marks,restricted
R7269	T10609	T10610	det	a,boundary
R7270	T10610	T10608	dobj	boundary,marks
R7271	T10611	T10610	compound	lineage,boundary
R7272	T10612	T10610	amod	coincident,boundary
R7273	T10613	T10612	prep	with,coincident
R7274	T10614	T10615	det	the,midline
R7275	T10615	T10613	pobj	midline,with
R7276	T10616	T10615	amod	dorsoventral,midline
R7277	T10617	T10615	prep	of,midline
R7278	T10618	T10619	det	the,ridge
R7279	T10619	T10617	pobj	ridge,of
R7280	T10620	T10619	amod	apical,ridge
R7281	T10621	T10619	amod	ectodermal,ridge
R7282	T10622	T10623	punct	(,Michaud
R7283	T10623	T10608	meta	Michaud,marks
R7284	T10624	T10623	nmod	Altabef,Michaud
R7285	T10625	T10623	nmod	et,Michaud
R7286	T10626	T10623	nmod	al.,Michaud
R7287	T10627	T10623	nummod	1997,Michaud
R7288	T10628	T10623	punct	;,Michaud
R7289	T10629	T10623	nmod	et,Michaud
R7290	T10630	T10623	nmod	al.,Michaud
R7291	T10631	T10623	nummod	1997,Michaud
R7292	T10632	T10623	punct	;,Michaud
R7293	T10633	T10623	nmod	Kimmel,Michaud
R7294	T10634	T10623	nmod	et,Michaud
R7295	T10635	T10623	nmod	al.,Michaud
R7296	T10636	T10623	nummod	2000,Michaud
R7297	T10637	T10623	punct	),Michaud
R7298	T10638	T10574	punct	.,restricted
R7299	T10640	T10641	mark	As,described
R7300	T10641	T10642	advcl	described,reported
R7301	T10643	T10641	advmod	above,described
R7302	T10644	T10642	punct	", ",reported
R7303	T10645	T10646	nmod	En1,mutations
R7304	T10646	T10642	nsubjpass	mutations,reported
R7305	T10647	T10645	cc	or,En1
R7306	T10648	T10645	conj	Wnt7a,En1
R7307	T10649	T10642	aux	have,reported
R7308	T10650	T10642	neg	not,reported
R7309	T10651	T10642	auxpass	been,reported
R7310	T10652	T10653	aux	to,affect
R7311	T10653	T10642	xcomp	affect,reported
R7312	T10654	T10653	dobj	patterns,affect
R7313	T10655	T10654	prep	of,patterns
R7314	T10656	T10657	compound	hair,color
R7315	T10657	T10659	compound	color,distribution
R7316	T10658	T10657	punct	-,color
R7317	T10659	T10655	pobj	distribution,of
R7318	T10660	T10661	punct	(,C.
R7319	T10661	T10642	meta	C.,reported
R7320	T10662	T10661	nmod	Loomis,C.
R7321	T10663	T10661	punct	", ",C.
R7322	T10664	T10665	amod	personal,communication
R7323	T10665	T10661	conj	communication,C.
R7324	T10666	T10665	punct	;,communication
R7325	T10667	T10665	conj	Parr,communication
R7326	T10668	T10667	cc	and,Parr
R7327	T10669	T10667	conj	McMahon,Parr
R7328	T10670	T10669	nummod	1995,McMahon
R7329	T10671	T10669	punct	;,McMahon
R7330	T10672	T10669	conj	Loomis,McMahon
R7331	T10673	T10672	nmod	et,Loomis
R7332	T10674	T10672	advmod	al.,Loomis
R7333	T10675	T10672	nummod	1996,Loomis
R7334	T10676	T10672	punct	),Loomis
R7335	T10677	T10642	punct	.,reported
R7336	T10679	T10680	advmod	However,apply
R7337	T10681	T10680	punct	", ",apply
R7338	T10682	T10683	det	the,theme
R7339	T10683	T10680	nsubj	theme,apply
R7340	T10684	T10683	amod	essential,theme
R7341	T10685	T10686	mark	that,control
R7342	T10686	T10683	acl	control,theme
R7343	T10687	T10688	amod	ectodermal,compartments
R7344	T10688	T10686	nsubj	compartments,control
R7345	T10689	T10688	compound	lineage,compartments
R7346	T10690	T10691	det	the,fate
R7347	T10691	T10686	dobj	fate,control
R7348	T10692	T10691	prep	of,fate
R7349	T10693	T10694	amod	underlying,mesenchyme
R7350	T10694	T10692	pobj	mesenchyme,of
R7351	T10695	T10686	prep	in,control
R7352	T10696	T10697	amod	developing,limbs
R7353	T10697	T10695	pobj	limbs,in
R7354	T10698	T10680	aux	may,apply
R7355	T10699	T10680	prep	to,apply
R7356	T10700	T10701	det	the,trunk
R7357	T10701	T10699	pobj	trunk,to
R7358	T10702	T10703	advmod	as,as
R7359	T10703	T10701	cc	as,trunk
R7360	T10704	T10703	advmod	well,as
R7361	T10705	T10706	det	the,limb
R7362	T10706	T10701	conj	limb,trunk
R7363	T10707	T10680	punct	.,apply
R7364	T10709	T10710	det	The,glands
R7365	T10710	T10712	nsubj	glands,develop
R7366	T10711	T10710	amod	mammary,glands
R7367	T10713	T10712	advmod	also,develop
R7368	T10714	T10712	prep	at,develop
R7369	T10715	T10716	det	a,position
R7370	T10716	T10714	pobj	position,at
R7371	T10717	T10716	amod	stereotyped,position
R7372	T10718	T10716	amod	dorsoventral,position
R7373	T10719	T10712	cc	and,develop
R7374	T10720	T10712	conj	depend,develop
R7375	T10721	T10720	prep	on,depend
R7376	T10722	T10723	amod	epithelial,mesenchymal
R7377	T10723	T10725	amod	mesenchymal,interactions
R7378	T10724	T10723	punct	–,mesenchymal
R7379	T10725	T10721	pobj	interactions,on
R7380	T10726	T10712	punct	.,develop
R7381	T10728	T10729	advmod	However,are
R7382	T10730	T10729	punct	", ",are
R7383	T10731	T10732	det	the,number
R7384	T10732	T10729	nsubj	number,are
R7385	T10733	T10732	cc	and,number
R7386	T10734	T10735	amod	apparent,position
R7387	T10735	T10732	conj	position,number
R7388	T10736	T10732	prep	of,number
R7389	T10737	T10738	det	the,glands
R7390	T10738	T10736	pobj	glands,of
R7391	T10739	T10738	amod	mammary,glands
R7392	T10740	T10729	acomp	normal,are
R7393	T10741	T10729	prep	in,are
R7394	T10742	T10743	compound	deH,deH
R7395	T10743	T10745	compound	deH,animals
R7396	T10744	T10743	punct	/,deH
R7397	T10745	T10741	pobj	animals,in
R7398	T10746	T10729	punct	", ",are
R7399	T10747	T10729	advcl	indicating,are
R7400	T10748	T10749	det	the,existence
R7401	T10749	T10747	dobj	existence,indicating
R7402	T10750	T10749	prep	of,existence
R7403	T10751	T10752	amod	additional,mechanisms
R7404	T10752	T10750	pobj	mechanisms,of
R7405	T10753	T10754	dep	that,control
R7406	T10754	T10752	relcl	control,mechanisms
R7407	T10755	T10756	amod	dorsoventral,patterning
R7408	T10756	T10754	dobj	patterning,control
R7409	T10757	T10754	prep	in,control
R7410	T10758	T10759	det	the,trunk
R7411	T10759	T10757	pobj	trunk,in
R7412	T10760	T10761	advmod	as,as
R7413	T10761	T10757	cc	as,in
R7414	T10762	T10761	advmod	well,as
R7415	T10763	T10757	conj	in,in
R7416	T10764	T10765	det	the,limbs
R7417	T10765	T10763	pobj	limbs,in
R7418	T10766	T10729	punct	.,are
R7419	T10768	T10769	det	These,ideas
R7420	T10769	T10770	nsubjpass	ideas,summarized
R7421	T10771	T10770	auxpass	are,summarized
R7422	T10772	T10770	prep	in,summarized
R7423	T10773	T10774	det	the,model
R7424	T10774	T10772	pobj	model,in
R7425	T10775	T10774	acl	shown,model
R7426	T10776	T10775	prep	in,shown
R7427	T10777	T10776	pobj	Figure,in
R7428	T10778	T10777	nummod	9B,Figure
R7429	T10779	T10770	punct	.,summarized
R7430	T10781	T10782	nsubj	We,speculate
R7431	T10783	T10784	mark	that,promotes
R7432	T10784	T10782	ccomp	promotes,speculate
R7433	T10785	T10786	det	a,signal
R7434	T10786	T10784	nsubj	signal,promotes
R7435	T10787	T10786	amod	diffusible,signal
R7436	T10788	T10786	prep	from,signal
R7437	T10789	T10790	amod	dorsal,ectoderm
R7438	T10790	T10788	pobj	ectoderm,from
R7439	T10791	T10790	compound	trunk,ectoderm
R7440	T10792	T10784	punct	", ",promotes
R7441	T10793	T10784	prep	at,promotes
R7442	T10794	T10793	cc	or,at
R7443	T10795	T10796	advmod	prior,E11.5
R7444	T10796	T10793	conj	E11.5,at
R7445	T10797	T10795	prep	to,prior
R7446	T10798	T10784	punct	", ",promotes
R7447	T10799	T10784	dobj	expression,promotes
R7448	T10800	T10799	prep	of,expression
R7449	T10801	T10800	pobj	Tbx15,of
R7450	T10802	T10799	prep	in,expression
R7451	T10803	T10804	amod	dorsal,mesenchyme
R7452	T10804	T10802	pobj	mesenchyme,in
R7453	T10805	T10804	compound	trunk,mesenchyme
R7454	T10806	T10799	punct	", ",expression
R7455	T10807	T10808	dep	which,establishes
R7456	T10808	T10799	relcl	establishes,expression
R7457	T10809	T10808	advmod	then,establishes
R7458	T10810	T10811	amod	dorsal,identity
R7459	T10811	T10808	dobj	identity,establishes
R7460	T10812	T10811	amod	positional,identity
R7461	T10813	T10811	prep	of,identity
R7462	T10814	T10815	det	those,cells
R7463	T10815	T10813	pobj	cells,of
R7464	T10816	T10817	mark	as,manifested
R7465	T10817	T10808	advcl	manifested,establishes
R7466	T10818	T10817	agent	by,manifested
R7467	T10819	T10818	pobj	differences,by
R7468	T10820	T10819	prep	in,differences
R7469	T10821	T10822	compound	Agouti,expression
R7470	T10822	T10820	pobj	expression,in
R7471	T10823	T10822	punct	", ",expression
R7472	T10824	T10825	compound	pigment,cell
R7473	T10825	T10827	compound	cell,development
R7474	T10826	T10825	punct	-,cell
R7475	T10827	T10822	conj	development,expression
R7476	T10828	T10827	punct	", ",development
R7477	T10829	T10827	cc	and,development
R7478	T10830	T10831	compound	hair,growth
R7479	T10831	T10827	conj	growth,development
R7480	T10832	T10782	punct	.,speculate
R7481	T10834	T10835	mark	Because,corresponds
R7482	T10835	T10842	advcl	corresponds,depict
R7483	T10836	T10837	det	the,limit
R7484	T10837	T10835	nsubj	limit,corresponds
R7485	T10838	T10837	amod	ventral,limit
R7486	T10839	T10837	prep	of,limit
R7487	T10840	T10841	compound	Tbx15,expression
R7488	T10841	T10839	pobj	expression,of
R7489	T10843	T10835	prep	to,corresponds
R7490	T10844	T10845	det	the,limit
R7491	T10845	T10843	pobj	limit,to
R7492	T10846	T10845	amod	dorsal,limit
R7493	T10847	T10845	prep	of,limit
R7494	T10848	T10849	compound	En1,expression
R7495	T10849	T10847	pobj	expression,of
R7496	T10850	T10835	cc	and,corresponds
R7497	T10851	T10852	mark	because,lies
R7498	T10852	T10835	conj	lies,corresponds
R7499	T10853	T10854	det	the,position
R7500	T10854	T10852	nsubj	position,lies
R7501	T10855	T10854	amod	normal,position
R7502	T10856	T10854	prep	of,position
R7503	T10857	T10858	det	the,boundary
R7504	T10858	T10856	pobj	boundary,of
R7505	T10859	T10858	compound	pigmentation,boundary
R7506	T10860	T10861	advmod	approximately,in
R7507	T10861	T10852	prep	in,lies
R7508	T10862	T10861	pobj	register,in
R7509	T10863	T10862	prep	with,register
R7510	T10864	T10865	det	the,outgrowths
R7511	T10865	T10863	pobj	outgrowths,with
R7512	T10866	T10867	compound	limb,bud
R7513	T10867	T10865	compound	bud,outgrowths
R7514	T10868	T10867	punct	-,bud
R7515	T10869	T10842	punct	", ",depict
R7516	T10870	T10842	nsubj	we,depict
R7517	T10871	T10872	det	the,position
R7518	T10872	T10842	dobj	position,depict
R7519	T10873	T10872	prep	of,position
R7520	T10874	T10875	det	a,boundary
R7521	T10875	T10873	pobj	boundary,of
R7522	T10876	T10875	amod	putative,boundary
R7523	T10877	T10875	amod	dorsoventral,boundary
R7524	T10878	T10842	prep	in,depict
R7525	T10879	T10880	compound	trunk,ectoderm
R7526	T10880	T10878	pobj	ectoderm,in
R7527	T10881	T10842	prep	as,depict
R7528	T10882	T10881	amod	coincident,as
R7529	T10883	T10882	prep	with,coincident
R7530	T10884	T10885	det	the,boundary
R7531	T10885	T10883	pobj	boundary,with
R7532	T10886	T10885	nmod	limb,boundary
R7533	T10887	T10885	amod	dorsoventral,boundary
R7534	T10888	T10842	punct	.,depict
R7535	T10890	T10891	det	This,model
R7536	T10891	T10892	nsubj	model,is
R7537	T10893	T10892	acomp	consistent,is
R7538	T10894	T10893	prep	with,consistent
R7539	T10895	T10894	pobj	studies,with
R7540	T10896	T10895	prep	in,studies
R7541	T10897	T10898	det	the,chick
R7542	T10898	T10896	pobj	chick,in
R7543	T10899	T10898	punct	", ",chick
R7544	T10900	T10901	advmod	where,exist
R7545	T10901	T10898	relcl	exist,chick
R7546	T10902	T10903	amod	distinct,compartments
R7547	T10903	T10901	nsubj	compartments,exist
R7548	T10904	T10903	amod	dorsal,compartments
R7549	T10905	T10904	cc	and,dorsal
R7550	T10906	T10904	conj	ventral,dorsal
R7551	T10907	T10903	compound	lineage,compartments
R7552	T10908	T10901	prep	for,exist
R7553	T10909	T10908	pobj	ectoderm,for
R7554	T10910	T10901	prep	in,exist
R7555	T10911	T10912	preconj	both,limb
R7556	T10912	T10910	pobj	limb,in
R7557	T10913	T10912	det	the,limb
R7558	T10914	T10915	punct	(,Michaud
R7559	T10915	T10912	meta	Michaud,limb
R7560	T10916	T10915	nmod	Altabef,Michaud
R7561	T10917	T10915	nmod	et,Michaud
R7562	T10918	T10915	nmod	al.,Michaud
R7563	T10919	T10915	nummod	1997,Michaud
R7564	T10920	T10915	punct	", ",Michaud
R7565	T10921	T10915	nummod	2000,Michaud
R7566	T10922	T10915	punct	;,Michaud
R7567	T10923	T10915	nmod	et,Michaud
R7568	T10924	T10915	nmod	al.,Michaud
R7569	T10925	T10915	nummod	1997,Michaud
R7570	T10926	T10915	punct	;,Michaud
R7571	T10927	T10915	nmod	Kimmel,Michaud
R7572	T10928	T10915	nmod	et,Michaud
R7573	T10929	T10915	nmod	al.,Michaud
R7574	T10930	T10915	nummod	2000,Michaud
R7575	T10931	T10915	punct	),Michaud
R7576	T10932	T10912	cc	and,limb
R7577	T10933	T10934	amod	interlimb,regions
R7578	T10934	T10912	conj	regions,limb
R7579	T10935	T10936	punct	(,Altabef
R7580	T10936	T10934	meta	Altabef,regions
R7581	T10937	T10936	nmod	et,Altabef
R7582	T10938	T10936	nmod	al.,Altabef
R7583	T10939	T10936	nummod	1997,Altabef
R7584	T10940	T10936	punct	", ",Altabef
R7585	T10941	T10936	nummod	2000,Altabef
R7586	T10942	T10936	punct	),Altabef
R7587	T10943	T10901	punct	", ",exist
R7588	T10944	T10945	cc	but,for
R7589	T10945	T10901	prep	for,exist
R7590	T10946	T10945	neg	not,for
R7591	T10947	T10948	compound	limb,mesoderm
R7592	T10948	T10945	pobj	mesoderm,for
R7593	T10949	T10950	punct	(,Altabef
R7594	T10950	T10948	meta	Altabef,mesoderm
R7595	T10951	T10950	nmod	et,Altabef
R7596	T10952	T10950	nmod	al.,Altabef
R7597	T10953	T10950	nummod	1997,Altabef
R7598	T10954	T10950	punct	;,Altabef
R7599	T10955	T10950	nmod	Michaud,Altabef
R7600	T10956	T10950	nmod	et,Altabef
R7601	T10957	T10950	nmod	al.,Altabef
R7602	T10958	T10950	nummod	1997,Altabef
R7603	T10959	T10950	punct	),Altabef
R7604	T10960	T10892	punct	.,is
R7605	T10962	T10963	prep	In,act
R7606	T10964	T10962	pobj	fact,In
R7607	T10965	T10963	punct	", ",act
R7608	T10966	T10967	det	the,mechanism
R7609	T10967	T10963	nsubj	mechanism,act
R7610	T10968	T10967	amod	same,mechanism
R7611	T10969	T10970	dep	that,determines
R7612	T10970	T10967	relcl	determines,mechanism
R7613	T10971	T10972	amod	dorsoventral,position
R7614	T10972	T10970	dobj	position,determines
R7615	T10973	T10972	prep	of,position
R7616	T10974	T10975	det	the,limbs
R7617	T10975	T10973	pobj	limbs,of
R7618	T10976	T10975	cc	and,limbs
R7619	T10977	T10978	det	the,ridge
R7620	T10978	T10975	conj	ridge,limbs
R7621	T10979	T10978	amod	apical,ridge
R7622	T10980	T10978	amod	ectodermal,ridge
R7623	T10981	T10963	aux	may,act
R7624	T10982	T10963	advmod	also,act
R7625	T10983	T10963	prep	on,act
R7626	T10984	T10983	pobj	expression,on
R7627	T10985	T10984	prep	of,expression
R7628	T10986	T10985	pobj	Tbx15,of
R7629	T10987	T10963	prep	in,act
R7630	T10988	T10989	det	the,trunk
R7631	T10989	T10987	pobj	trunk,in
R7632	T10990	T10963	punct	", ",act
R7633	T10991	T10992	mark	since,develop
R7634	T10992	T10963	advcl	develop,act
R7635	T10993	T10994	amod	ectopic,limbs
R7636	T10994	T10992	nsubj	limbs,develop
R7637	T10995	T10994	acl	induced,limbs
R7638	T10996	T10995	prep	in,induced
R7639	T10997	T10998	det	the,region
R7640	T10998	T10996	pobj	region,in
R7641	T10999	T10998	amod	interlimb,region
R7642	T11000	T10995	prep	by,induced
R7643	T11001	T11000	pobj	application,by
R7644	T11002	T11001	prep	of,application
R7645	T11003	T11004	compound	FGF,beads
R7646	T11004	T11002	pobj	beads,of
R7647	T11005	T10992	prep	along,develop
R7648	T11006	T11007	det	a,line
R7649	T11007	T11005	pobj	line,along
R7650	T11008	T11007	amod	single,line
R7651	T11009	T11010	dep	that,is
R7652	T11010	T11007	relcl	is,line
R7653	T11011	T11010	acomp	coincident,is
R7654	T11012	T11011	prep	with,coincident
R7655	T11013	T11014	amod	normal,buds
R7656	T11014	T11012	pobj	buds,with
R7657	T11015	T11014	compound	limb,buds
R7658	T11016	T11014	punct	(,buds
R7659	T11017	T11014	cc	and,buds
R7660	T11018	T11019	det	the,boundary
R7661	T11019	T11014	conj	boundary,buds
R7662	T11020	T11019	amod	future,boundary
R7663	T11021	T11019	compound	pigmentation,boundary
R7664	T11022	T10992	punct	),develop
R7665	T11023	T11024	punct	(,Cohn
R7666	T11024	T10992	meta	Cohn,develop
R7667	T11025	T11024	nmod	et,Cohn
R7668	T11026	T11024	nmod	al.,Cohn
R7669	T11027	T11024	nummod	1995,Cohn
R7670	T11028	T11024	punct	;,Cohn
R7671	T11029	T11024	nmod	Crossley,Cohn
R7672	T11030	T11024	nmod	et,Cohn
R7673	T11031	T11024	nmod	al.,Cohn
R7674	T11032	T11024	nummod	1996,Cohn
R7675	T11033	T11024	punct	;,Cohn
R7676	T11034	T11024	nmod	Vogel,Cohn
R7677	T11035	T11024	nmod	et,Cohn
R7678	T11036	T11024	nmod	al.,Cohn
R7679	T11037	T11024	nummod	1996,Cohn
R7680	T11038	T11024	punct	;,Cohn
R7681	T11039	T11024	nmod	Altabef,Cohn
R7682	T11040	T11024	nmod	et,Cohn
R7683	T11041	T11024	nmod	al.,Cohn
R7684	T11042	T11024	nummod	1997,Cohn
R7685	T11043	T11024	punct	", ",Cohn
R7686	T11044	T11024	nummod	2000,Cohn
R7687	T11045	T11024	punct	),Cohn
R7688	T11046	T10963	punct	.,act
R7689	T11048	T11049	poss	Our,model
R7690	T11049	T11050	nsubj	model,predicts
R7691	T11051	T11052	mark	that,give
R7692	T11052	T11050	ccomp	give,predicts
R7693	T11053	T11054	amod	ectopic,expression
R7694	T11054	T11052	nsubj	expression,give
R7695	T11055	T11054	prep	of,expression
R7696	T11056	T11055	pobj	Tbx15,of
R7697	T11057	T11054	prep	in,expression
R7698	T11058	T11059	amod	ventral,mesenchyme
R7699	T11059	T11057	pobj	mesenchyme,in
R7700	T11060	T11052	aux	should,give
R7701	T11061	T11052	dobj	rise,give
R7702	T11062	T11052	prep	to,give
R7703	T11063	T11064	det	a,phenotype
R7704	T11064	T11062	pobj	phenotype,to
R7705	T11065	T11064	amod	dorsalized,phenotype
R7706	T11066	T11064	compound	pigmentation,phenotype
R7707	T11067	T11052	cc	and,give
R7708	T11068	T11069	aux	could,tested
R7709	T11069	T11052	conj	tested,give
R7710	T11070	T11069	auxpass	be,tested
R7711	T11071	T11069	prep	with,tested
R7712	T11072	T11073	nmod	gain,approaches
R7713	T11073	T11071	pobj	approaches,with
R7714	T11074	T11072	punct	-,gain
R7715	T11075	T11072	prep	of,gain
R7716	T11076	T11075	punct	-,of
R7717	T11077	T11075	pobj	function,of
R7718	T11078	T11050	punct	.,predicts
R7719	T11080	T11081	advmod	However,is
R7720	T11082	T11081	punct	", ",is
R7721	T11083	T11084	compound	Tbx15,expression
R7722	T11084	T11081	nsubj	expression,is
R7723	T11085	T11086	advmod	very,dynamic
R7724	T11086	T11081	acomp	dynamic,is
R7725	T11087	T11081	cc	and,is
R7726	T11088	T11089	auxpass	is,restricted
R7727	T11089	T11081	conj	restricted,is
R7728	T11090	T11089	prep	to,restricted
R7729	T11091	T11092	amod	dorsal,mesoderm
R7730	T11092	T11090	pobj	mesoderm,to
R7731	T11093	T11094	advmod	only,from
R7732	T11094	T11089	prep	from,restricted
R7733	T11095	T11094	pobj	E11.5,from
R7734	T11096	T11094	prep	to,from
R7735	T11097	T11096	pobj	E13.5,to
R7736	T11098	T11081	punct	.,is
R7737	T11100	T11101	nsubj	It,is
R7738	T11101	T11102	ccomp	is,require
R7739	T11103	T11101	acomp	possible,is
R7740	T11104	T11105	mark	that,influences
R7741	T11105	T11101	ccomp	influences,is
R7742	T11106	T11105	nsubj	Tbx15,influences
R7743	T11107	T11108	compound	skin,patterning
R7744	T11108	T11105	dobj	patterning,influences
R7745	T11109	T11105	prep	in,influences
R7746	T11110	T11111	det	a,window
R7747	T11111	T11109	pobj	window,in
R7748	T11112	T11113	advmod	very,narrow
R7749	T11113	T11111	amod	narrow,window
R7750	T11114	T11111	prep	of,window
R7751	T11115	T11114	pobj	development,of
R7752	T11116	T11102	punct	;,require
R7753	T11117	T11102	advmod	alternatively,require
R7754	T11118	T11102	punct	", ",require
R7755	T11119	T11102	nsubj	establishment,require
R7756	T11120	T11119	prep	of,establishment
R7757	T11121	T11122	amod	dorsal,identity
R7758	T11122	T11120	pobj	identity,of
R7759	T11123	T11119	prep	by,establishment
R7760	T11124	T11123	pobj	Tbx15,by
R7761	T11125	T11102	aux	may,require
R7762	T11126	T11127	det	another,factor
R7763	T11127	T11102	dobj	factor,require
R7764	T11128	T11129	advmod	as,yet
R7765	T11129	T11131	advmod	yet,unidentified
R7766	T11130	T11129	punct	-,yet
R7767	T11131	T11127	amod	unidentified,factor
R7768	T11132	T11131	punct	-,unidentified
R7769	T11133	T11134	dep	that,is
R7770	T11134	T11127	relcl	is,factor
R7771	T11135	T11134	advmod	only,is
R7772	T11136	T11134	acomp	present,is
R7773	T11137	T11134	prep	in,is
R7774	T11138	T11139	det	the,mesenchyme
R7775	T11139	T11137	pobj	mesenchyme,in
R7776	T11140	T11139	acl	underlying,mesenchyme
R7777	T11141	T11142	amod	dorsal,ectoderm
R7778	T11142	T11140	dobj	ectoderm,underlying
R7779	T11143	T11102	punct	.,require
R7780	T11305	T11306	compound	Pigmentation,Patterns
R7781	T11307	T11306	cc	and,Patterns
R7782	T11308	T11306	conj	Tbx15,Patterns
R7783	T11309	T11306	prep	in,Patterns
R7784	T11310	T11311	amod	Other,Mammals
R7785	T11311	T11309	pobj	Mammals,in
R7786	T11313	T11314	det	The,frontier
R7787	T11314	T11317	nsubjpass	frontier,established
R7788	T11315	T11314	amod	lateral,frontier
R7789	T11316	T11314	amod	somitic,frontier
R7790	T11318	T11314	punct	", ",frontier
R7791	T11319	T11314	acl	defined,frontier
R7792	T11320	T11319	prep	as,defined
R7793	T11321	T11322	det	the,boundary
R7794	T11322	T11320	pobj	boundary,as
R7795	T11323	T11322	compound	lineage,boundary
R7796	T11324	T11322	prep	between,boundary
R7797	T11325	T11326	npadvmod	somite,derived
R7798	T11326	T11328	amod	derived,mesoderm
R7799	T11327	T11326	punct	-,derived
R7800	T11328	T11324	pobj	mesoderm,between
R7801	T11329	T11326	cc	versus,derived
R7802	T11330	T11331	amod	lateral,plate
R7803	T11331	T11332	npadvmod	plate,derived
R7804	T11332	T11326	conj	derived,derived
R7805	T11333	T11332	punct	-,derived
R7806	T11334	T11317	punct	", ",established
R7807	T11335	T11317	auxpass	is,established
R7808	T11336	T11317	prep	during,established
R7809	T11337	T11336	pobj	somitogenesis,during
R7810	T11338	T11339	advmod	early,in
R7811	T11339	T11317	prep	in,established
R7812	T11340	T11339	pobj	development,in
R7813	T11341	T11342	punct	(,Mauger
R7814	T11342	T11317	meta	Mauger,established
R7815	T11343	T11342	nummod	1972,Mauger
R7816	T11344	T11342	punct	;,Mauger
R7817	T11345	T11342	nmod	Christ,Mauger
R7818	T11346	T11342	nmod	et,Mauger
R7819	T11347	T11342	nmod	al.,Mauger
R7820	T11348	T11342	nummod	1983,Mauger
R7821	T11349	T11342	punct	;,Mauger
R7822	T11350	T11342	nmod	Olivera,Mauger
R7823	T11351	T11342	punct	-,Mauger
R7824	T11352	T11342	nmod	Martinez,Mauger
R7825	T11353	T11342	nmod	et,Mauger
R7826	T11354	T11342	nmod	al.,Mauger
R7827	T11355	T11342	nummod	2000,Mauger
R7828	T11356	T11342	punct	;,Mauger
R7829	T11357	T11342	nmod	Nowicki,Mauger
R7830	T11358	T11342	nmod	et,Mauger
R7831	T11359	T11342	nmod	al.,Mauger
R7832	T11360	T11342	nummod	2003,Mauger
R7833	T11361	T11342	punct	),Mauger
R7834	T11362	T11317	punct	", ",established
R7835	T11363	T11317	cc	but,established
R7836	T11364	T11317	conj	remains,established
R7837	T11365	T11364	oprd	distinct,remains
R7838	T11366	T11364	prep	in,remains
R7839	T11367	T11368	amod	postnatal,animals
R7840	T11368	T11366	pobj	animals,in
R7841	T11369	T11364	prep	despite,remains
R7842	T11370	T11371	det	the,potential
R7843	T11371	T11369	pobj	potential,despite
R7844	T11372	T11371	prep	for,potential
R7845	T11373	T11374	amod	extensive,mixing
R7846	T11374	T11372	pobj	mixing,for
R7847	T11375	T11374	compound	cell,mixing
R7848	T11376	T11377	punct	(,see
R7849	T11377	T11364	parataxis	see,remains
R7850	T11378	T11377	dobj	Figure,see
R7851	T11379	T11378	nummod	8,Figure
R7852	T11380	T11377	punct	),see
R7853	T11381	T11317	punct	.,established
R7854	T11383	T11384	advmod	However,demonstrate
R7855	T11385	T11384	punct	", ",demonstrate
R7856	T11386	T11387	poss	our,studies
R7857	T11387	T11384	nsubj	studies,demonstrate
R7858	T11388	T11387	nmod	transplantation,studies
R7859	T11389	T11388	cc	and,transplantation
R7860	T11390	T11388	conj	fate,transplantation
R7861	T11391	T11390	punct	-,fate
R7862	T11392	T11390	amod	mapping,fate
R7863	T11393	T11394	mark	that,lies
R7864	T11394	T11384	ccomp	lies,demonstrate
R7865	T11395	T11396	det	the,frontier
R7866	T11396	T11394	nsubj	frontier,lies
R7867	T11397	T11396	amod	lateral,frontier
R7868	T11398	T11396	amod	somitic,frontier
R7869	T11399	T11394	advmod	dorsal,lies
R7870	T11400	T11399	prep	to,dorsal
R7871	T11401	T11402	det	the,boundary
R7872	T11402	T11400	pobj	boundary,to
R7873	T11403	T11402	compound	pigmentation,boundary
R7874	T11404	T11394	cc	and,lies
R7875	T11405	T11406	aux	does,correlate
R7876	T11406	T11394	conj	correlate,lies
R7877	T11407	T11406	neg	not,correlate
R7878	T11408	T11406	advmod	obviously,correlate
R7879	T11409	T11406	prep	with,correlate
R7880	T11410	T11411	det	a,difference
R7881	T11411	T11409	pobj	difference,with
R7882	T11412	T11411	prep	in,difference
R7883	T11413	T11414	compound	skin,morphology
R7884	T11414	T11412	pobj	morphology,in
R7885	T11415	T11384	punct	.,demonstrate
R7886	T11417	T11418	det	An,domain
R7887	T11418	T11421	nsubj	domain,emerged
R7888	T11419	T11418	amod	additional,domain
R7889	T11420	T11418	amod	dorsoventral,domain
R7890	T11422	T11423	dep	that,is
R7891	T11423	T11418	relcl	is,domain
R7892	T11424	T11423	neg	not,is
R7893	T11425	T11426	advmod	externally,apparent
R7894	T11426	T11423	acomp	apparent,is
R7895	T11427	T11421	aux	has,emerged
R7896	T11428	T11421	prep	from,emerged
R7897	T11429	T11428	pobj	studies,from
R7898	T11430	T11429	prep	of,studies
R7899	T11431	T11430	pobj	Msx1,of
R7900	T11432	T11431	punct	", ",Msx1
R7901	T11433	T11434	poss	whose,expression
R7902	T11434	T11435	dep	expression,marks
R7903	T11435	T11431	relcl	marks,Msx1
R7904	T11436	T11437	det	a,subgroup
R7905	T11437	T11435	dobj	subgroup,marks
R7906	T11438	T11437	prep	of,subgroup
R7907	T11439	T11440	npadvmod	somite,derived
R7908	T11440	T11442	amod	derived,cells
R7909	T11441	T11440	punct	-,derived
R7910	T11442	T11438	pobj	cells,of
R7911	T11443	T11442	amod	mesenchymal,cells
R7912	T11444	T11445	dep	that,contribute
R7913	T11445	T11437	relcl	contribute,subgroup
R7914	T11446	T11445	prep	to,contribute
R7915	T11447	T11446	pobj	dermis,to
R7916	T11448	T11445	prep	in,contribute
R7917	T11449	T11450	det	a,stripe
R7918	T11450	T11448	pobj	stripe,in
R7919	T11451	T11450	amod	narrow,stripe
R7920	T11452	T11450	prep	along,stripe
R7921	T11453	T11454	det	the,region
R7922	T11454	T11452	pobj	region,along
R7923	T11455	T11454	amod	paraspinal,region
R7924	T11456	T11457	punct	(,Houzelstein
R7925	T11457	T11421	meta	Houzelstein,emerged
R7926	T11458	T11457	nmod	et,Houzelstein
R7927	T11459	T11457	nmod	al.,Houzelstein
R7928	T11460	T11457	nummod	2000,Houzelstein
R7929	T11461	T11457	punct	),Houzelstein
R7930	T11462	T11421	punct	.,emerged
R7931	T11464	T11465	advmod	Thus,exist
R7932	T11466	T11465	punct	", ",exist
R7933	T11467	T11465	expl	there,exist
R7934	T11468	T11469	advmod	at,three
R7935	T11469	T11471	nummod	three,boundaries
R7936	T11470	T11469	advmod	least,three
R7937	T11471	T11465	dobj	boundaries,exist
R7938	T11472	T11471	amod	distinct,boundaries
R7939	T11473	T11471	prep	in,boundaries
R7940	T11474	T11475	amod	postnatal,skin
R7941	T11475	T11473	pobj	skin,in
R7942	T11476	T11475	amod	mammalian,skin
R7943	T11477	T11478	dep	that,are
R7944	T11478	T11471	relcl	are,boundaries
R7945	T11479	T11478	acomp	parallel,are
R7946	T11480	T11479	prep	to,parallel
R7947	T11481	T11482	det	the,plane
R7948	T11482	T11480	pobj	plane,to
R7949	T11483	T11482	amod	sagittal,plane
R7950	T11484	T11471	punct	", ",boundaries
R7951	T11485	T11471	acl	marked,boundaries
R7952	T11486	T11485	agent	by,marked
R7953	T11487	T11486	pobj	differences,by
R7954	T11488	T11487	prep	in,differences
R7955	T11489	T11490	compound	pigment,type
R7956	T11490	T11492	compound	type,synthesis
R7957	T11491	T11490	punct	-,type
R7958	T11492	T11488	pobj	synthesis,in
R7959	T11493	T11487	punct	", ",differences
R7960	T11494	T11487	conj	differences,differences
R7961	T11495	T11494	prep	in,differences
R7962	T11496	T11497	compound	cell,lineage
R7963	T11497	T11495	pobj	lineage,in
R7964	T11498	T11494	punct	", ",differences
R7965	T11499	T11494	cc	and,differences
R7966	T11500	T11494	conj	differences,differences
R7967	T11501	T11500	prep	in,differences
R7968	T11502	T11501	pobj	expression,in
R7969	T11503	T11502	prep	of,expression
R7970	T11504	T11503	pobj	Msx1,of
R7971	T11505	T11465	punct	.,exist
R7972	T11507	T11508	prep	In,is
R7973	T11509	T11507	pobj	rodents,In
R7974	T11510	T11508	punct	", ",is
R7975	T11511	T11512	advmod	only,boundary
R7976	T11512	T11508	nsubj	boundary,is
R7977	T11513	T11512	det	the,boundary
R7978	T11514	T11512	compound	pigmentation,boundary
R7979	T11515	T11508	acomp	evident,is
R7980	T11516	T11508	advmod	externally,is
R7981	T11517	T11508	punct	", ",is
R7982	T11518	T11508	cc	but,is
R7983	T11519	T11520	amod	many,mammals
R7984	T11520	T11521	nsubj	mammals,have
R7985	T11521	T11508	conj	have,is
R7986	T11522	T11523	advmod	more,complicated
R7987	T11523	T11524	amod	complicated,patterns
R7988	T11524	T11521	dobj	patterns,have
R7989	T11525	T11524	prep	of,patterns
R7990	T11526	T11527	compound	hair,type
R7991	T11527	T11525	pobj	type,of
R7992	T11528	T11527	punct	", ",type
R7993	T11529	T11527	conj	length,type
R7994	T11530	T11529	punct	", ",length
R7995	T11531	T11529	cc	and,length
R7996	T11532	T11531	punct	/,and
R7997	T11533	T11531	cc	or,and
R7998	T11534	T11529	conj	color,length
R7999	T11535	T11536	dep	that,vary
R8000	T11536	T11524	relcl	vary,patterns
R8001	T11537	T11536	prep	along,vary
R8002	T11538	T11539	det	the,axis
R8003	T11539	T11537	pobj	axis,along
R8004	T11540	T11539	amod	dorsoventral,axis
R8005	T11541	T11521	punct	.,have
R8006	T11543	T11544	nsubj	Raccoons,exhibit
R8007	T11545	T11543	punct	", ",Raccoons
R8008	T11546	T11543	conj	squirrels,Raccoons
R8009	T11547	T11546	punct	", ",squirrels
R8010	T11548	T11546	conj	skunks,squirrels
R8011	T11549	T11548	punct	", ",skunks
R8012	T11550	T11548	cc	and,skunks
R8013	T11551	T11552	amod	many,ungulates
R8014	T11552	T11548	conj	ungulates,skunks
R8015	T11553	T11552	amod	different,ungulates
R8016	T11554	T11555	amod	lateral,stripes
R8017	T11555	T11544	dobj	stripes,exhibit
R8018	T11556	T11557	poss	whose,origins
R8019	T11557	T11559	dep	origins,investigated
R8020	T11558	T11557	amod	developmental,origins
R8021	T11559	T11555	relcl	investigated,stripes
R8022	T11560	T11559	aux	have,investigated
R8023	T11561	T11559	neg	not,investigated
R8024	T11562	T11559	auxpass	been,investigated
R8025	T11563	T11559	punct	", ",investigated
R8026	T11564	T11559	cc	but,investigated
R8027	T11565	T11566	aux	may,correspond
R8028	T11566	T11559	conj	correspond,investigated
R8029	T11567	T11566	prep	to,correspond
R8030	T11568	T11569	det	the,frontier
R8031	T11569	T11567	pobj	frontier,to
R8032	T11570	T11569	amod	lateral,frontier
R8033	T11571	T11569	amod	somitic,frontier
R8034	T11572	T11569	punct	", ",frontier
R8035	T11573	T11574	det	the,compartment
R8036	T11574	T11569	conj	compartment,frontier
R8037	T11575	T11574	amod	paraspinal,compartment
R8038	T11576	T11574	compound	Msx1,compartment
R8039	T11577	T11574	punct	", ",compartment
R8040	T11578	T11574	cc	or,compartment
R8041	T11579	T11580	det	an,interaction
R8042	T11580	T11574	conj	interaction,compartment
R8043	T11581	T11580	prep	between,interaction
R8044	T11582	T11583	det	these,domains
R8045	T11583	T11581	pobj	domains,between
R8046	T11584	T11544	punct	.,exhibit
R8047	T11586	T11587	det	The,effect
R8048	T11587	T11588	nsubj	effect,is
R8049	T11589	T11587	prep	of,effect
R8050	T11590	T11589	pobj	Tbx15,of
R8051	T11591	T11587	prep	on,effect
R8052	T11592	T11591	pobj	pigmentation,on
R8053	T11593	T11587	prep	in,effect
R8054	T11594	T11595	compound	laboratory,mice
R8055	T11595	T11593	pobj	mice,in
R8056	T11596	T11588	acomp	reminiscent,is
R8057	T11597	T11596	prep	of,reminiscent
R8058	T11598	T11599	compound	coat,color
R8059	T11599	T11601	compound	color,patterns
R8060	T11600	T11599	punct	-,color
R8061	T11601	T11597	pobj	patterns,of
R8062	T11602	T11601	prep	in,patterns
R8063	T11603	T11604	preconj	both,selected
R8064	T11604	T11605	amod	selected,populations
R8065	T11605	T11602	pobj	populations,in
R8066	T11606	T11604	cc	and,selected
R8067	T11607	T11604	conj	natural,selected
R8068	T11608	T11605	prep	of,populations
R8069	T11609	T11610	amod	other,mammals
R8070	T11610	T11608	pobj	mammals,of
R8071	T11611	T11588	punct	.,is
R8072	T11613	T11614	compound	Saddle,markings
R8073	T11614	T11615	nsubj	markings,are
R8074	T11616	T11615	acomp	common,are
R8075	T11617	T11615	prep	in,are
R8076	T11618	T11619	det	some,breeds
R8077	T11619	T11617	pobj	breeds,in
R8078	T11620	T11619	compound	dog,breeds
R8079	T11621	T11619	punct	", ",breeds
R8080	T11622	T11623	amod	such,as
R8081	T11623	T11619	prep	as,breeds
R8082	T11624	T11625	compound	German,shepherds
R8083	T11625	T11623	pobj	shepherds,as
R8084	T11626	T11617	punct	", ",in
R8085	T11627	T11617	cc	and,in
R8086	T11628	T11617	conj	in,in
R8087	T11629	T11630	amod	certain,populations
R8088	T11630	T11628	pobj	populations,in
R8089	T11631	T11630	prep	of,populations
R8090	T11632	T11633	compound	Peromyscus,polionotus
R8091	T11633	T11631	pobj	polionotus,of
R8092	T11634	T11630	punct	", ",populations
R8093	T11635	T11636	prep	in,provides
R8094	T11636	T11630	relcl	provides,populations
R8095	T11637	T11635	pobj	which,in
R8096	T11638	T11639	det	a,extension
R8097	T11639	T11636	nsubj	extension,provides
R8098	T11640	T11639	amod	dorsal,extension
R8099	T11641	T11639	prep	of,extension
R8100	T11642	T11643	amod	ventral,depigmentation
R8101	T11643	T11641	pobj	depigmentation,of
R8102	T11644	T11645	det	an,advantage
R8103	T11645	T11636	dobj	advantage,provides
R8104	T11646	T11645	amod	adaptive,advantage
R8105	T11647	T11636	dative	to,provides
R8106	T11648	T11647	pobj	subspecies,to
R8107	T11649	T11650	dep	that,live
R8108	T11650	T11648	relcl	live,subspecies
R8109	T11651	T11650	prep	on,live
R8110	T11652	T11653	amod	white,reefs
R8111	T11653	T11651	pobj	reefs,on
R8112	T11654	T11653	compound	sand,reefs
R8113	T11655	T11656	punct	(,Blair
R8114	T11656	T11615	meta	Blair,are
R8115	T11657	T11656	nummod	1951,Blair
R8116	T11658	T11656	punct	;,Blair
R8117	T11659	T11656	conj	Kaufman,Blair
R8118	T11660	T11659	nummod	1974,Kaufman
R8119	T11661	T11659	punct	;,Kaufman
R8120	T11662	T11659	conj	Belk,Kaufman
R8121	T11663	T11662	cc	and,Belk
R8122	T11664	T11662	conj	Smith,Belk
R8123	T11665	T11664	nummod	1996,Smith
R8124	T11666	T11664	punct	),Smith
R8125	T11667	T11615	punct	.,are
R8126	T11669	T11670	preconj	Neither,shepherds
R8127	T11670	T11672	nsubj	shepherds,have
R8128	T11671	T11670	compound	German,shepherds
R8129	T11673	T11670	cc	nor,shepherds
R8130	T11674	T11675	compound	deer,mice
R8131	T11675	T11670	conj	mice,shepherds
R8132	T11676	T11677	amod	craniofacial,characteristics
R8133	T11677	T11672	dobj	characteristics,have
R8134	T11678	T11677	amod	similar,characteristics
R8135	T11679	T11678	prep	to,similar
R8136	T11680	T11681	det	the,mutation
R8137	T11681	T11679	pobj	mutation,to
R8138	T11682	T11681	compound	deH,mutation
R8139	T11683	T11672	punct	", ",have
R8140	T11684	T11672	cc	but,have
R8141	T11685	T11686	det	the,patterns
R8142	T11686	T11688	nsubj	patterns,represent
R8143	T11687	T11686	compound	pigmentation,patterns
R8144	T11688	T11672	conj	represent,have
R8145	T11689	T11686	prep	in,patterns
R8146	T11690	T11691	det	these,animals
R8147	T11691	T11689	pobj	animals,in
R8148	T11692	T11688	aux	could,represent
R8149	T11693	T11688	dobj	alterations,represent
R8150	T11694	T11693	prep	in,alterations
R8151	T11695	T11696	det	the,regulation
R8152	T11696	T11694	pobj	regulation,in
R8153	T11697	T11696	cc	or,regulation
R8154	T11698	T11696	conj	action,regulation
R8155	T11699	T11696	prep	of,regulation
R8156	T11700	T11701	compound	Tbx15,activity
R8157	T11701	T11699	pobj	activity,of
R8158	T11702	T11688	punct	.,represent
R8159	T11704	T11705	prep	From,are
R8160	T11706	T11707	det	the,perspective
R8161	T11707	T11704	pobj	perspective,From
R8162	T11708	T11707	amod	opposite,perspective
R8163	T11709	T11705	punct	", ",are
R8164	T11710	T11711	det	the,effects
R8165	T11711	T11705	nsubj	effects,are
R8166	T11712	T11711	prep	of,effects
R8167	T11713	T11712	pobj	Tbx15,of
R8168	T11714	T11711	prep	on,effects
R8169	T11715	T11716	compound	coat,color
R8170	T11716	T11714	pobj	color,on
R8171	T11717	T11705	advmod	only,are
R8172	T11718	T11705	acomp	apparent,are
R8173	T11719	T11705	prep	in,are
R8174	T11720	T11721	amod	certain,backgrounds
R8175	T11721	T11719	pobj	backgrounds,in
R8176	T11722	T11721	amod	genetic,backgrounds
R8177	T11723	T11705	cc	and,are
R8178	T11724	T11725	aux	may,be
R8179	T11725	T11705	conj	be,are
R8180	T11726	T11725	neg	not,be
R8181	T11727	T11725	acomp	evident,be
R8182	T11728	T11729	advmod	at,all
R8183	T11729	T11725	advmod	all,be
R8184	T11730	T11725	prep	in,be
R8185	T11731	T11730	pobj	mammals,in
R8186	T11732	T11733	dep	that,lack
R8187	T11733	T11731	relcl	lack,mammals
R8188	T11734	T11735	amod	dorsoventral,patterns
R8189	T11735	T11733	dobj	patterns,lack
R8190	T11736	T11735	compound	pigmentation,patterns
R8191	T11737	T11705	punct	.,are
R8192	T11739	T11740	csubj	Studying,provide
R8193	T11741	T11742	det	the,sequence
R8194	T11742	T11739	dobj	sequence,Studying
R8195	T11743	T11742	cc	and,sequence
R8196	T11744	T11742	conj	expression,sequence
R8197	T11745	T11742	prep	of,sequence
R8198	T11746	T11745	pobj	Tbx15,of
R8199	T11747	T11739	prep	in,Studying
R8200	T11748	T11749	amod	other,vertebrates
R8201	T11749	T11747	pobj	vertebrates,in
R8202	T11750	T11740	aux	may,provide
R8203	T11751	T11752	amod	additional,insight
R8204	T11752	T11740	dobj	insight,provide
R8205	T11753	T11752	prep	into,insight
R8206	T11754	T11753	pobj	patterns,into
R8207	T11755	T11756	dep	that,affect
R8208	T11756	T11754	relcl	affect,patterns
R8209	T11757	T11758	det	the,skeleton
R8210	T11758	T11756	dobj	skeleton,affect
R8211	T11759	T11760	advmod	as,as
R8212	T11760	T11758	cc	as,skeleton
R8213	T11761	T11760	advmod	well,as
R8214	T11762	T11763	det	the,system
R8215	T11763	T11758	conj	system,skeleton
R8216	T11764	T11763	amod	pigmentary,system
R8217	T11765	T11740	punct	.,provide
R5959	T8677	T8675	ccomp	been,suggest

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T7470	33-38	SO:0000704	denotes	genes
T7471	87-100	UBERON:0002073	denotes	hair follicle
T7472	87-112	GO:0001942	denotes	hair follicle development
T7473	118-123	PR:000016145	denotes	Tbx15
T7474	136-140	SO:0000704	denotes	gene
T7475	191-195	UBERON:0001037	denotes	hair
T7476	279-283	UBERON:0001037	denotes	hair
T7477	291-296	UBERON:0002100	denotes	trunk
T7478	298-303	UBERON:0002101	denotes	limbs
T7479	354-358	NCBITaxon:10088	denotes	mice
T7480	371-376	UBERON:0002100	denotes	trunk
T7481	418-428	GO:0010467	denotes	expression
T7482	435-441	PR:000004372	denotes	Agouti
T7483	447-454	SO:0001060	denotes	isoform
T7484	508-514	SO:0001023	denotes	allele
T7485	570-575	PR:000016145	denotes	Tbx15
T7486	666-671	PR:000016145	denotes	Tbx15
T7487	718-722	SO:0000704	denotes	gene
T7488	791-796	SO:0000704	denotes	genes
T7489	824-844	SO:0001415	denotes	deletion breakpoints
T7490	854-864	GO:0010467	denotes	expression
T7491	876-881	PR:000016145	denotes	Tbx15
T7492	966-972	SO:0001023	denotes	allele
T7493	985-991	SO:0001023	denotes	allele
T7494	1004-1009	PR:000016145	denotes	Tbx15
T7495	1019-1025	SO:0001023	denotes	allele
T7496	1092-1102	GO:0010467	denotes	expression
T7497	1106-1111	PR:000016145	denotes	Tbx15
T7498	1194-1200	UBERON:0002067	denotes	dermis
T7499	1216-1226	CHEBI:26130	denotes	pigmentary
T7500	1231-1235	UBERON:0001037	denotes	hair
T7501	1275-1280	PR:000016145	denotes	Tbx15
T7502	1281-1291	GO:0010467	denotes	expression
T7503	1310-1315	UBERON:0000180	denotes	flank
T7504	1378-1382	UBERON:0002101	denotes	limb
T7505	1378-1394	GO:0060173	denotes	limb development
T7506	1410-1432	UBERON:0003081	denotes	lateral plate mesoderm
T7507	1482-1486	SO:0000704	denotes	gene
T7508	1497-1506	UBERON:0000922	denotes	embryonic
T7509	1497-1518	GO:0009790	denotes	embryonic development
T7510	1636-1645	NCBITaxon:40674	denotes	mammalian
T7875	1727-1733	GO:0007601	denotes	visual
T7876	1784-1788	NCBITaxon:10088	denotes	mice
T7877	1908-1912	SO:0000704	denotes	gene
T7878	1908-1923	GO:0010467	denotes	gene expression
T7879	1986-1992	PR:000004372	denotes	Agouti
T7880	2006-2015	UBERON:0000922	denotes	embryonic
T7881	2024-2029	GO:0007567	denotes	natal
T7882	2177-2181	UBERON:0001037	denotes	hair
T7883	2220-2231	CL:0000148	denotes	melanocytes
T7884	2396-2400	NCBITaxon:10088	denotes	mice
T7885	2467-2474	CHEBI:26130	denotes	pigment
T7886	2494-2501	CHEBI:26130	denotes	pigment
T7887	2556-2561	UBERON:0000180	denotes	flank
T7888	2600-2606	PR:000004372	denotes	Agouti
T7889	2646-2653	UBERON:0013235	denotes	ventrum
T7890	2659-2663	UBERON:0001037	denotes	hair
T7891	2664-2671	CHEBI:26130	denotes	pigment
T7892	2737-2744	UBERON:0013235	denotes	ventrum
T7893	2772-2779	SO:0000704	denotes	genetic
T7894	2842-2847	UBERON:0000180	denotes	flank
T7895	4120-4125	PR:000016145	denotes	Tbx15
T7896	4162-4166	UBERON:0001037	denotes	hair
T7897	4175-4182	CHEBI:26130	denotes	pigment
T7898	4196-4206	GO:0010467	denotes	expression
T7899	4231-4237	PR:000004372	denotes	Agouti
T7900	4238-4245	SO:0001060	denotes	isoform
T7901	4356-4361	UBERON:0007023	denotes	adult
T7902	4370-4374	NCBITaxon:10088	denotes	mice
T7903	4444-4448	NCBITaxon:10088	denotes	mice
T7904	4496-4502	UBERON:0007023	denotes	adults
T7905	4569-4573	UBERON:0001037	denotes	hair
T8302	4600-4605	PR:000016145	denotes	Tbx15
T8303	4646-4652	SO:0000417	denotes	domain
T8304	4677-4682	NCBITaxon:10088	denotes	mouse
T8305	4683-4692	PR:000016001	denotes	Brachyury
T8306	4693-4697	SO:0000704	denotes	gene
T8307	4733-4737	UBERON:0002415	denotes	tail
T8308	4757-4762	SO:0000704	denotes	genes
T8309	4834-4841	UBERON:0000479	denotes	tissues
T8310	4846-4869	UBERON:0000468	denotes	multicellular organisms
T8311	4860-4869	NCBITaxon:1	denotes	organisms
T8312	4906-4911	PR:000016145	denotes	Tbx15
T8313	4943-4948	PR:000016146	denotes	Tbx18
T8314	4953-4958	PR:000016150	denotes	Tbx22
T8315	4998-5006	NCBITaxon:7711	denotes	chordate
T8316	5041-5045	SO:0000704	denotes	gene
T8317	5049-5058	NCBITaxon:7740	denotes	amphioxus
T8318	5074-5081	SO:0000853	denotes	homolog
T8319	5089-5092	NCBITaxon:7147	denotes	fly
T8320	5093-5099	SO:0001026	denotes	genome
T8321	5169-5174	SO:0000704	denotes	genes
T8322	5179-5188	GO:0010467	denotes	expressed
T8323	5245-5252	UBERON:0002329	denotes	somites
T8324	5254-5259	PR:000016146	denotes	Tbx18
T8325	5264-5269	PR:000016150	denotes	Tbx22
T8326	5272-5287	UBERON:0009749	denotes	limb mesenchyme
T8327	5289-5294	PR:000016145	denotes	Tbx15
T8328	5299-5304	PR:000016146	denotes	Tbx18
T8329	5324-5334	UBERON:0003104	denotes	mesenchyme
T8330	5346-5351	SO:0000704	denotes	genes
T8331	5353-5358	PR:000016145	denotes	Tbx15
T8332	5377-5382	PR:000016146	denotes	Tbx18
T8333	5386-5391	PR:000016150	denotes	Tbx22
T8334	5539-5543	SO:0000704	denotes	gene
T8335	5548-5553	PR:000016145	denotes	Tbx15
T8336	5555-5560	PR:000016146	denotes	Tbx18
T8337	5566-5571	PR:000016150	denotes	Tbx22
T8338	5628-5644	NCBITaxon:7735	denotes	cephalochordates
T8339	5677-5687	GO:0010467	denotes	expression
T8340	5732-5736	UBERON:0002101	denotes	limb
T8341	5745-5750	UBERON:0002100	denotes	trunk
T8342	5764-5774	NCBITaxon:7742	denotes	vertebrate
T8343	5786-5796	GO:0010467	denotes	Expression
T8344	5800-5805	PR:000016146	denotes	Tbx18
T8345	5810-5815	PR:000016150	denotes	Tbx22
T8346	5841-5850	UBERON:0000922	denotes	embryonic
T8347	5851-5856	UBERON:0000180	denotes	flank
T8348	5857-5867	UBERON:0003104	denotes	mesenchyme
T8349	5889-5894	PR:000016145	denotes	Tbx15
T8350	5979-5984	UBERON:0002100	denotes	trunk
T8351	6070-6077	NCBITaxon:33208	denotes	animals
T8352	6168-6173	UBERON:0002101	denotes	limbs
T8353	6182-6186	UBERON:0000033	denotes	head
T8354	6214-6219	PR:000016150	denotes	Tbx22
T8355	6230-6235	NCBITaxon:9606	denotes	human
T8356	6245-6246	GO:0000805	denotes	X
T8357	6333-6338	PR:000016150	denotes	Tbx22
T8358	6339-6349	GO:0010467	denotes	expression
T8359	6353-6363	_FRAGMENT	denotes	periocular
T8360	6374-6384	UBERON:0004017	denotes	mesenchyme
T8361	6364-6373	UBERON:0000922	denotes	embryonic
T8362	6480-6483	UBERON:0000970	denotes	eye
T8363	6534-6539	PR:000016145	denotes	Tbx15
T8364	6593-6603	GO:0010467	denotes	expression
T8365	6624-6629	NCBITaxon:10088	denotes	mouse
T8366	6630-6635	PR:000016145	denotes	Tbx15
T8367	6669-6674	NCBITaxon:9606	denotes	human
T8368	6675-6680	PR:000016145	denotes	Tbx15
T8369	6744-6750	UBERON:0001456	denotes	facial
T8370	6893-6902	GO:0030849	denotes	autosomal
T8371	6938-6944	UBERON:0001456	denotes	facial
T8372	6980-6984	UBERON:0000165	denotes	oral
T8373	6985-6991	UBERON:0000344	denotes	mucosa
T8374	7011-7016	UBERON:0002398	denotes	hands
T8375	7360-7365	NCBITaxon:9606	denotes	human
T8376	7366-7371	PR:000016145	denotes	TBX15
T8377	7420-7429	GO:0030849	denotes	autosomal
T8378	7504-7511	UBERON:0004089	denotes	midface
T8379	7649-7657	UBERON:0004288	denotes	skeletal
T8380	7649-7669	GO:0001501	denotes	skeletal development
T8381	7731-7735	SO:0000704	denotes	gene
T8382	7736-7740	PR:000003979	denotes	Alx3
T8383	7750-7757	SO:0001023	denotes	allelic
T8384	7770-7773	UBERON:0001690	denotes	ear
T8385	7832-7840	UBERON:0004288	denotes	skeletal
T8386	7863-7867	PR:000003979	denotes	Alx3
T8387	7871-7875	PR:000003980	denotes	Alx4
T8388	7948-7952	PR:000003979	denotes	Alx3
T8389	7992-7997	PR:000016145	denotes	Tbx15
T8390	7998-8006	UBERON:0004288	denotes	skeletal
T9202	8074-8079	PR:000016145	denotes	Tbx15
T9203	8080-8090	GO:0010467	denotes	Expression
T9204	8143-8148	PR:000016145	denotes	Tbx15
T9205	8152-8159	CHEBI:26130	denotes	pigment
T9206	8203-8209	PR:000004372	denotes	Agouti
T9207	8217-8222	GO:0007567	denotes	natal
T9208	8223-8230	NCBITaxon:33208	denotes	animals
T9209	8241-8247	PR:000004372	denotes	Agouti
T9210	8256-8265	GO:0010467	denotes	expressed
T9211	8273-8279	UBERON:0000922	denotes	embryo
T9212	8330-8336	UBERON:0002067	denotes	dermis
T9213	8377-8386	UBERON:0000922	denotes	embryonic
T9214	8387-8393	PR:000004372	denotes	Agouti
T9215	8394-8404	GO:0010467	denotes	expression
T9216	8416-8423	NCBITaxon:33208	denotes	animals
T9217	8463-8468	PR:000016145	denotes	Tbx15
T9218	8545-8550	SO:0000704	denotes	genes
T9219	8798-8824	_FRAGMENT	denotes	proliferative expansion of
T9220	8827-8842	GO:0008283	denotes	cell population
T9221	8998-9002	NCBITaxon:10088	denotes	mice
T9222	9046-9052	PR:000004372	denotes	Agouti
T9223	9053-9063	GO:0010467	denotes	expression
T9224	9071-9076	GO:0007567	denotes	natal
T9225	9085-9092	NCBITaxon:33208	denotes	animals
T9226	9186-9195	UBERON:0000922	denotes	embryonic
T9227	9186-9201	CL:0002321	denotes	embryonic cells
T9228	9218-9228	UBERON:0003104	denotes	mesenchyme
T9229	9303-9314	GO:0008283	denotes	proliferate
T9230	9529-9533	UBERON:0001037	denotes	hair
T9231	9551-9555	NCBITaxon:10088	denotes	mice
T9232	9672-9677	UBERON:0000180	denotes	flank
T9233	9704-9713	UBERON:0000922	denotes	embryonic
T9234	9714-9724	UBERON:0003104	denotes	mesenchyme
T9235	9726-9736	GO:0010467	denotes	expression
T9236	9740-9745	PR:000016145	denotes	Tbx15
T9237	9750-9756	PR:000004372	denotes	Agouti
T9238	9800-9805	PR:000016145	denotes	Tbx15
T9239	9831-9837	PR:000004372	denotes	Agouti
T9240	9868-9878	UBERON:0003104	denotes	mesenchyme
T9241	9904-9909	PR:000016145	denotes	Tbx15
T9242	9922-9932	GO:0010467	denotes	expression
T9243	9957-9963	PR:000004372	denotes	Agouti
T9244	9964-9971	SO:0001060	denotes	isoform
T9245	9979-9984	GO:0007567	denotes	natal
T9246	9985-9989	NCBITaxon:10088	denotes	mice
T9247	10026-10031	GO:0007567	denotes	natal
T9248	10032-10042	GO:0010467	denotes	expression
T9249	10046-10051	PR:000016145	denotes	Tbx15
T9250	10133-10139	PR:000004372	denotes	Agouti
T9251	10172-10177	PR:000016145	denotes	Tbx15
T9252	10205-10210	SO:0000704	denotes	genes
T9253	10226-10232	PR:000004372	denotes	Agouti
T9254	10240-10244	UBERON:0001037	denotes	hair
T9255	10240-10244	_FRAGMENT	denotes	hair
T9256	10256-10266	CL:0002483	denotes	melanocyte
T9257	10333-10340	NCBITaxon:33208	denotes	animals
T9258	10359-10365	PR:000004372	denotes	Agouti
T9259	10366-10372	SO:0001023	denotes	allele
T9260	10398-10402	PR:000003980	denotes	Alx4
T9261	10416-10422	PR:000004372	denotes	Agouti
T9262	10427-10436	GO:0010467	denotes	expressed
T9263	10448-10457	UBERON:0000922	denotes	embryonic
T9264	10458-10468	UBERON:0003104	denotes	mesenchyme
T9265	10497-10510	UBERON:0002073	denotes	hair-follicle
T9266	10522-10526	UBERON:0002101	denotes	limb
T9267	10522-10526	_FRAGMENT	denotes	limb
T9268	10544-10555	GO:0060173	denotes	development
T9269	10650-10660	GO:0010467	denotes	expression
T9270	10688-10692	PR:000003980	denotes	Alx4
T9271	10705-10709	PR:000003979	denotes	Alx3
T9272	10714-10718	PR:000010687	denotes	Msx2
T9273	10765-10772	UBERON:0000922	denotes	embryos
T10004	12465-12475	GO:0010467	denotes	expression
T9952	10837-10841	UBERON:0002101	denotes	Limb
T9953	10861-10866	PR:000016145	denotes	Tbx15
T9954	10905-10909	UBERON:0001037	denotes	hair
T9955	10923-10928	UBERON:0002101	denotes	limbs
T9956	10975-10979	UBERON:0001037	denotes	hair
T9957	11002-11006	UBERON:0001037	denotes	hair
T9958	11052-11059	CHEBI:26130	denotes	pigment
T9959	11082-11086	UBERON:0002101	denotes	limb
T9960	11119-11123	NCBITaxon:10088	denotes	mice
T9961	11210-11213	PR:000007070	denotes	En1
T9962	11217-11222	PR:000017448	denotes	Wnt7a
T9963	11275-11279	UBERON:0002101	denotes	limb
T9964	11285-11291	UBERON:0001137	denotes	dorsum
T9965	11295-11302	UBERON:0013235	denotes	ventrum
T9966	11327-11334	UBERON:0013235	denotes	ventrum
T9967	11338-11344	UBERON:0001137	denotes	dorsum
T9968	11423-11429	PR:000004372	denotes	Agouti
T9969	11430-11440	GO:0010467	denotes	expression
T9970	11460-11464	UBERON:0001037	denotes	hair
T9971	11545-11553	UBERON:0013623	denotes	footpads
T9972	11571-11574	PR:000007070	denotes	En1
T9973	11582-11586	NCBITaxon:10088	denotes	mice
T9974	11603-11610	CHEBI:26130	denotes	pigment
T9975	11672-11675	PR:000007070	denotes	En1
T9976	11692-11697	PR:000017448	denotes	Wnt7a
T9977	11710-11719	_FRAGMENT	denotes	migration
T9978	11747-11749	_FRAGMENT	denotes	of
T9979	11758-11763	GO:0016477	denotes	cells
T9980	11723-11736	_FRAGMENT	denotes	proliferation
T9981	11758-11763	GO:0008283	denotes	cells
T9982	11750-11757	CHEBI:26130	denotes	pigment
T9983	11750-11763	CL:0000147	denotes	pigment cells
T9984	11775-11784	UBERON:0007376	denotes	epidermis
T9985	11865-11872	GO:0065007	denotes	control
T9986	11889-11894	UBERON:0002100	denotes	trunk
T9987	11906-11911	PR:000016145	denotes	Tbx15
T9988	11941-11948	GO:0065007	denotes	control
T9989	11965-11969	UBERON:0002101	denotes	limb
T9990	11984-11989	PR:000009871	denotes	Lmx1b
T9991	11997-12003	SO:0000417	denotes	domain
T9992	12049-12054	PR:000017448	denotes	Wnt7a
T9993	12059-12062	PR:000007070	denotes	En1
T9994	12190-12195	PR:000016145	denotes	Tbx15
T9995	12200-12205	PR:000009871	denotes	Lmx1b
T9996	12226-12237	UBERON:0003104	denotes	mesenchymal
T9997	12226-12243	CL:0000134	denotes	mesenchymal cells
T9998	12283-12293	GO:0010467	denotes	expression
T9999	12361-12366	UBERON:0000180	denotes	flank
T10000	12368-12373	PR:000016145	denotes	Tbx15
T10001	12382-12386	UBERON:0002101	denotes	limb
T10002	12388-12393	PR:000009871	denotes	Lmx1b
T10003	12454-12459	PR:000009871	denotes	Lmx1b
T10005	12490-12494	UBERON:0002101	denotes	limb
T10006	12506-12511	PR:000017448	denotes	Wnt7a
T10007	12545-12553	UBERON:0000924	denotes	ectoderm
T10008	12615-12620	PR:000017448	denotes	Wnt7a
T10009	12655-12663	UBERON:0000924	denotes	ectoderm
T10010	12667-12670	PR:000007070	denotes	En1
T10011	12686-12694	UBERON:0000924	denotes	ectoderm
T10012	12761-12771	GO:0010467	denotes	expression
T10013	12845-12868	UBERON:0004356	denotes	apical ectodermal ridge
T10014	12953-12956	PR:000007070	denotes	En1
T10015	12960-12965	PR:000017448	denotes	Wnt7a
T10016	13021-13025	UBERON:0001037	denotes	hair
T10017	13159-13169	UBERON:0000924	denotes	ectodermal
T10018	13191-13198	GO:0065007	denotes	control
T10019	13222-13232	UBERON:0003104	denotes	mesenchyme
T10020	13247-13252	UBERON:0002101	denotes	limbs
T10021	13270-13275	UBERON:0002100	denotes	trunk
T10022	13291-13295	UBERON:0002101	denotes	limb
T10023	13301-13315	UBERON:0001911	denotes	mammary glands
T10024	13382-13392	UBERON:0000483	denotes	epithelial
T10025	13393-13404	UBERON:0003104	denotes	mesenchymal
T10026	13468-13482	UBERON:0001911	denotes	mammary glands
T10027	13505-13512	NCBITaxon:33208	denotes	animals
T10028	13569-13576	GO:0065007	denotes	control
T10029	13608-13613	UBERON:0002100	denotes	trunk
T10030	13632-13637	UBERON:0002101	denotes	limbs
T10031	13742-13754	UBERON:0011270	denotes	dorsal trunk
T10032	13755-13763	UBERON:0000924	denotes	ectoderm
T10033	13796-13806	GO:0010467	denotes	expression
T10034	13810-13815	PR:000016145	denotes	Tbx15
T10035	13819-13831	UBERON:0011270	denotes	dorsal trunk
T10036	13832-13842	UBERON:0003104	denotes	mesenchyme
T10037	13941-13947	PR:000004372	denotes	Agouti
T10038	13948-13958	GO:0010467	denotes	expression
T10039	13960-13967	CHEBI:26130	denotes	pigment
T10040	13960-13972	CL:0000147	denotes	pigment-cell
T10041	13960-13984	GO:0070285	denotes	pigment-cell development
T10042	13990-13994	UBERON:0001037	denotes	hair
T10043	14032-14037	PR:000016145	denotes	Tbx15
T10044	14038-14048	GO:0010467	denotes	expression
T10045	14084-14087	PR:000007070	denotes	En1
T10046	14088-14098	GO:0010467	denotes	expression
T10047	14200-14208	UBERON:0004347	denotes	limb-bud
T10048	14283-14288	UBERON:0002100	denotes	trunk
T10049	14289-14297	UBERON:0000924	denotes	ectoderm
T10050	14321-14325	UBERON:0002101	denotes	limb
T10051	14466-14474	UBERON:0000924	denotes	ectoderm
T10052	14487-14491	UBERON:0002101	denotes	limb
T10053	14570-14574	UBERON:0002101	denotes	limb
T10054	14624-14628	UBERON:0002101	denotes	limb
T10055	14629-14637	UBERON:0000926	denotes	mesoderm
T10056	14755-14760	UBERON:0002101	denotes	limbs
T10057	14769-14792	UBERON:0004356	denotes	apical ectodermal ridge
T10058	14809-14819	GO:0010467	denotes	expression
T10059	14823-14828	PR:000016145	denotes	Tbx15
T10060	14836-14841	UBERON:0002100	denotes	trunk
T10061	14857-14862	UBERON:0002101	denotes	limbs
T10062	14883-14887	UBERON:0002101	denotes	limb
T10063	14982-14991	UBERON:0004347	denotes	limb buds
T10064	15151-15161	GO:0010467	denotes	expression
T10065	15165-15170	PR:000016145	denotes	Tbx15
T10066	15174-15192	UBERON:2000164	denotes	ventral mesenchyme
T10067	15312-15317	PR:000016145	denotes	Tbx15
T10068	15318-15328	GO:0010467	denotes	expression
T10069	15373-15381	UBERON:0000926	denotes	mesoderm
T10070	15428-15433	PR:000016145	denotes	Tbx15
T10071	15516-15548	GO:0048263	denotes	establishment of dorsal identity
T10072	15552-15557	PR:000016145	denotes	Tbx15
T10073	15633-15643	UBERON:0003104	denotes	mesenchyme
T10074	15662-15670	UBERON:0000924	denotes	ectoderm
T11185	15699-15704	PR:000016145	denotes	Tbx15
T11186	15714-15721	NCBITaxon:40674	denotes	Mammals
T11187	15734-15750	UBERON:0015178	denotes	somitic frontier
T11188	15792-15798	UBERON:0002329	denotes	somite
T11189	15814-15827	UBERON:0003081	denotes	lateral plate
T11190	15836-15844	UBERON:0000926	denotes	mesoderm
T11191	16017-16022	GO:0007567	denotes	natal
T11192	16023-16030	NCBITaxon:33208	denotes	animals
T11193	16178-16194	UBERON:0015178	denotes	somitic frontier
T11194	16401-16405	PR:000010686	denotes	Msx1
T11195	16413-16423	GO:0010467	denotes	expression
T11196	16444-16450	UBERON:0002329	denotes	somite
T11197	16459-16470	UBERON:0003104	denotes	mesenchymal
T11198	16459-16476	CL:0000134	denotes	mesenchymal cells
T11199	16496-16502	UBERON:0002067	denotes	dermis
T11200	16515-16521	UBERON:2001463	denotes	stripe
T11201	16637-16642	GO:0007567	denotes	natal
T11202	16643-16652	NCBITaxon:40674	denotes	mammalian
T11203	16724-16731	CHEBI:26130	denotes	pigment
T11204	16796-16806	GO:0010467	denotes	expression
T11205	16810-16814	PR:000010686	denotes	Msx1
T11206	16819-16826	NCBITaxon:9989	denotes	rodents
T11207	16891-16898	NCBITaxon:40674	denotes	mammals
T11208	16933-16937	UBERON:0001037	denotes	hair
T11209	17004-17012	NCBITaxon:9654	denotes	Raccoons
T11210	17014-17023	NCBITaxon:55153	denotes	squirrels
T11211	17025-17031	NCBITaxon:119825	denotes	skunks
T11212	17078-17085	UBERON:2001463	denotes	stripes
T11213	17176-17192	UBERON:0015178	denotes	somitic frontier
T11214	17209-17213	PR:000010686	denotes	Msx1
T11215	17282-17287	PR:000016145	denotes	Tbx15
T11216	17318-17322	NCBITaxon:10088	denotes	mice
T11217	17341-17345	UBERON:0010166	denotes	coat
T11218	17411-17418	NCBITaxon:40674	denotes	mammals
T11219	17427-17435	UBERON:2002284	denotes	markings
T11220	17455-17458	NCBITaxon:9615	denotes	dog
T11221	17523-17544	NCBITaxon:42413	denotes	Peromyscus polionotus
T11222	17634-17644	NCBITaxon:subspecies	denotes	subspecies
T11223	17753-17762	NCBITaxon:10040	denotes	deer mice
T11224	17865-17872	NCBITaxon:33208	denotes	animals
T11225	17908-17918	GO:0065007	denotes	regulation
T11226	17932-17937	PR:000016145	denotes	Tbx15
T11227	17994-17999	PR:000016145	denotes	Tbx15
T11228	18003-18007	UBERON:0010166	denotes	coat
T11229	18043-18050	SO:0000704	denotes	genetic
T11230	18096-18103	NCBITaxon:40674	denotes	mammals
T11231	18176-18186	GO:0010467	denotes	expression
T11232	18190-18195	PR:000016145	denotes	Tbx15
T11233	18205-18216	NCBITaxon:7742	denotes	vertebrates
T11234	18278-18286	UBERON:0004288	denotes	skeleton
T11235	18302-18312	CHEBI:26130	denotes	pigmentary
R6399	T9220	T9219	_lexicallyChainedTo	cell population,proliferative expansion of
R5785	T8360	T8359	_lexicallyChainedTo	mesenchyme,periocular
R6400	T9256	T9255	_lexicallyChainedTo	melanocyte,hair
R6401	T9268	T9267	_lexicallyChainedTo	development,limb
R6888	T9978	T9977	_lexicallyChainedTo	of,migration
R6889	T9978	T9980	_lexicallyChainedTo	of,proliferation
R6890	T9979	T9978	_lexicallyChainedTo	cells,of
R6891	T9981	T9978	_lexicallyChainedTo	cells,of

2_test

Id	Subject	Object	Predicate	Lexical cue
14737183-10431194-84903016	1970-1974	10431194	denotes	1999
14737183-11352264-84903017	4895-4899	11352264	denotes	2001
14737183-11063699-84903018	5117-5121	11063699	denotes	2000
14737183-9693034-84903019	5409-5413	9693034	denotes	1998
14737183-11118889-84903020	5428-5432	11118889	denotes	2001
14737183-12374769-84903021	5451-5455	12374769	denotes	2002
14737183-12412015-84903022	5469-5473	12412015	denotes	2002
14737183-12666195-84903023	5487-5491	12666195	denotes	2003
14737183-11559848-84903024	6303-6307	11559848	denotes	2001
14737183-12374769-84903025	6403-6407	12374769	denotes	2002
14737183-12412015-84903026	6421-6425	12412015	denotes	2002
14737183-12666195-84903027	6439-6443	12666195	denotes	2003
14737183-9693034-84903028	6653-6657	9693034	denotes	1998
14737183-3989825-84903029	6855-6859	3989825	denotes	1985
14737183-1619638-84903030	7166-7170	1619638	denotes	1992
14737183-8950682-84903031	7186-7190	8950682	denotes	1996
14737183-9546838-84903032	7208-7212	9546838	denotes	1998
14737183-10955485-84903033	7229-7233	10955485	denotes	2000
14737183-8205327-84903034	7539-7543	8205327	denotes	1994
14737183-13654621-84903035	7677-7681	13654621	denotes	1959
14737183-9676189-84903036	7792-7796	9676189	denotes	1998
14737183-11148447-84903037	8904-8908	11148447	denotes	2001
14737183-9374397-84903038	10567-10571	9374397	denotes	1997
14737183-9636085-84903039	10573-10577	9636085	denotes	1998
14737183-11017806-84903040	10589-10593	11017806	denotes	2000
14737183-11106354-84903041	10608-10612	11106354	denotes	2000
14737183-11137991-84903042	10634-10638	11137991	denotes	2001
14737183-8684466-84903043	11318-11322	8684466	denotes	1996
14737183-7885472-84903044	11363-11367	7885472	denotes	1995
14737183-9362463-84903045	11799-11803	9362463	denotes	1997
14737183-9463360-84903046	11819-11823	9463360	denotes	1998
14737183-7585966-84903047	12078-12082	7585966	denotes	1995
14737183-7501017-84903048	12097-12101	7501017	denotes	1995
14737183-9362463-84903049	12116-12120	9362463	denotes	1997
14737183-9199358-84903050	12135-12139	9199358	denotes	1997
14737183-9463360-84903051	12155-12159	9463360	denotes	1998
14737183-12455631-84903052	12178-12182	12455631	denotes	2002
14737183-9409672-84903053	12411-12415	9409672	denotes	1997
14737183-9108362-84903054	12432-12436	9108362	denotes	1997
14737183-7585966-84903055	12569-12573	7585966	denotes	1995
14737183-9362463-84903056	12588-12592	9362463	denotes	1997
14737183-9463360-84903057	12608-12612	9463360	denotes	1998
14737183-8684466-84903058	12710-12714	8684466	denotes	1996
14737183-9362463-84903059	12729-12733	9362463	denotes	1997
14737183-9199358-84903060	12748-12752	9199358	denotes	1997
14737183-9409672-84903061	12885-12889	9409672	denotes	1997
14737183-9108362-84903062	12906-12910	9108362	denotes	1997
14737183-10837030-84903063	12926-12930	10837030	denotes	2000
14737183-7885472-84903064	13098-13102	7885472	denotes	1995
14737183-8684466-84903065	13118-13122	8684466	denotes	1996
14737183-9409672-84903066	14508-14512	9409672	denotes	1997
14737183-10837120-84903067	14514-14518	10837120	denotes	2000
14737183-9108362-84903068	14535-14539	9108362	denotes	1997
14737183-10837030-84903069	14555-14559	10837030	denotes	2000
14737183-9409672-84903070	14599-14603	9409672	denotes	1997
14737183-10837120-84903071	14605-14609	10837120	denotes	2000
14737183-9409672-84903072	14654-14658	9409672	denotes	1997
14737183-9108362-84903073	14675-14679	9108362	denotes	1997
14737183-7889567-84903074	15044-15048	7889567	denotes	1995
14737183-8548816-84903075	15066-15070	8548816	denotes	1996
14737183-8674413-84903076	15085-15089	8674413	denotes	1996
14737183-9409672-84903077	15106-15110	9409672	denotes	1997
14737183-10837120-84903078	15112-15116	10837120	denotes	2000
14737183-4642991-84903079	15911-15915	4642991	denotes	1972
14737183-6220621-84903080	15931-15935	6220621	denotes	1983
14737183-11023864-84903081	15961-15965	11023864	denotes	2000
14737183-12559495-84903082	15982-15986	12559495	denotes	2003
14737183-10769239-84903083	16570-16574	10769239	denotes	2000
T72218	1970-1974	10431194	denotes	1999
T16759	4895-4899	11352264	denotes	2001
T67028	5117-5121	11063699	denotes	2000
T4817	5409-5413	9693034	denotes	1998
T78537	5428-5432	11118889	denotes	2001
T43597	5451-5455	12374769	denotes	2002
T38490	5469-5473	12412015	denotes	2002
T88434	5487-5491	12666195	denotes	2003
T74339	6303-6307	11559848	denotes	2001
T15308	6403-6407	12374769	denotes	2002
T32618	6421-6425	12412015	denotes	2002
T92387	6439-6443	12666195	denotes	2003
T15261	6653-6657	9693034	denotes	1998
T25076	6855-6859	3989825	denotes	1985
T77501	7166-7170	1619638	denotes	1992
T34635	7186-7190	8950682	denotes	1996
T3233	7208-7212	9546838	denotes	1998
T70122	7229-7233	10955485	denotes	2000
T57391	7539-7543	8205327	denotes	1994
T36001	7677-7681	13654621	denotes	1959
T91162	7792-7796	9676189	denotes	1998
T39299	8904-8908	11148447	denotes	2001
T6389	10567-10571	9374397	denotes	1997
T79404	10573-10577	9636085	denotes	1998
T15242	10589-10593	11017806	denotes	2000
T53983	10608-10612	11106354	denotes	2000
T15933	10634-10638	11137991	denotes	2001
T53460	11318-11322	8684466	denotes	1996
T23024	11363-11367	7885472	denotes	1995
T39161	11799-11803	9362463	denotes	1997
T1447	11819-11823	9463360	denotes	1998
T84663	12078-12082	7585966	denotes	1995
T8856	12097-12101	7501017	denotes	1995
T98636	12116-12120	9362463	denotes	1997
T54739	12135-12139	9199358	denotes	1997
T26592	12155-12159	9463360	denotes	1998
T81941	12178-12182	12455631	denotes	2002
T19075	12411-12415	9409672	denotes	1997
T17053	12432-12436	9108362	denotes	1997
T53896	12569-12573	7585966	denotes	1995
T93804	12588-12592	9362463	denotes	1997
T59441	12608-12612	9463360	denotes	1998
T52288	12710-12714	8684466	denotes	1996
T44539	12729-12733	9362463	denotes	1997
T74279	12748-12752	9199358	denotes	1997
T19781	12885-12889	9409672	denotes	1997
T45236	12906-12910	9108362	denotes	1997
T38996	12926-12930	10837030	denotes	2000
T51426	13098-13102	7885472	denotes	1995
T14969	13118-13122	8684466	denotes	1996
T73550	14508-14512	9409672	denotes	1997
T91787	14514-14518	10837120	denotes	2000
T44919	14535-14539	9108362	denotes	1997
T6564	14555-14559	10837030	denotes	2000
T18378	14599-14603	9409672	denotes	1997
T78045	14605-14609	10837120	denotes	2000
T27101	14654-14658	9409672	denotes	1997
T88287	14675-14679	9108362	denotes	1997
T4989	15044-15048	7889567	denotes	1995
T75351	15066-15070	8548816	denotes	1996
T64302	15085-15089	8674413	denotes	1996
T69447	15106-15110	9409672	denotes	1997
T50326	15112-15116	10837120	denotes	2000
T86561	15911-15915	4642991	denotes	1972
T25548	15931-15935	6220621	denotes	1983
T21422	15961-15965	11023864	denotes	2000
T12096	15982-15986	12559495	denotes	2003
T65500	16570-16574	10769239	denotes	2000

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T7511	19-28	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T7512	33-38	SO_EXT:0000704	denotes	genes
T7513	87-100	UBERON:0002073	denotes	hair follicle
T7514	87-112	GO:0001942	denotes	hair follicle development
T7515	118-123	PR_EXT:000016145	denotes	Tbx15
T7516	136-140	SO_EXT:0000704	denotes	gene
T7517	191-195	UBERON:0001037	denotes	hair
T7518	196-208	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T7519	222-226	UBERON_EXT:body	denotes	body
T7520	279-283	UBERON:0001037	denotes	hair
T7521	291-296	UBERON:0002100	denotes	trunk
T7522	298-303	UBERON:0002101	denotes	limbs
T7523	309-321	UBERON_EXT:face_or_skull	denotes	craniofacial
T7524	354-358	NCBITaxon:10088	denotes	mice
T7525	371-376	UBERON:0002100	denotes	trunk
T7526	418-428	GO:0010467	denotes	expression
T7527	435-441	PR_EXT:000004372	denotes	Agouti
T7528	442-446	CHEBI_SO_EXT:mRNA	denotes	mRNA
T7529	447-454	SO_EXT:0001060	denotes	isoform
T7530	494-498	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T7531	508-514	SO_EXT:0001023	denotes	allele
T7532	536-544	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T7533	570-575	PR_EXT:000016145	denotes	Tbx15
T7534	576-591	SO_EXT:coding_sequence	denotes	coding sequence
T7535	666-671	PR_EXT:000016145	denotes	Tbx15
T7536	718-722	SO_EXT:0000704	denotes	gene
T7537	791-796	SO_EXT:0000704	denotes	genes
T7538	824-844	SO_EXT:0001415	denotes	deletion breakpoints
T7539	854-864	GO:0010467	denotes	expression
T7540	876-881	PR_EXT:000016145	denotes	Tbx15
T7541	966-972	SO_EXT:0001023	denotes	allele
T7542	985-991	SO_EXT:0001023	denotes	allele
T7543	1004-1009	PR_EXT:000016145	denotes	Tbx15
T7544	1019-1025	SO_EXT:0001023	denotes	allele
T7545	1082-1091	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterned
T7546	1092-1102	GO:0010467	denotes	expression
T7547	1106-1111	PR_EXT:000016145	denotes	Tbx15
T7548	1194-1200	UBERON:0002067	denotes	dermis
T7549	1216-1226	CHEBI_EXT:26130	denotes	pigmentary
T7550	1231-1235	UBERON:0001037	denotes	hair
T7551	1243-1253	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterning
T7552	1275-1280	PR_EXT:000016145	denotes	Tbx15
T7553	1281-1291	GO:0010467	denotes	expression
T7554	1310-1315	UBERON:0000180	denotes	flank
T7555	1378-1382	UBERON:0002101	denotes	limb
T7556	1378-1394	GO:0060173	denotes	limb development
T7557	1410-1432	UBERON:0003081	denotes	lateral plate mesoderm
T7558	1482-1486	SO_EXT:0000704	denotes	gene
T7559	1497-1506	UBERON:0000922	denotes	embryonic
T7560	1497-1518	GO:0009790	denotes	embryonic development
T7561	1636-1645	NCBITaxon:40674	denotes	mammalian
T7562	1646-1650	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T7906	1727-1733	GO:0007601	denotes	visual
T7907	1770-1774	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T7908	1784-1788	NCBITaxon:10088	denotes	mice
T7909	1908-1912	SO_EXT:0000704	denotes	gene
T7910	1908-1923	GO:0010467	denotes	gene expression
T7911	1928-1932	CL_GO_EXT:cell	denotes	cell
T7912	1986-1992	PR_EXT:000004372	denotes	Agouti
T7913	1993-1997	CHEBI_SO_EXT:mRNA	denotes	mRNA
T7914	2006-2015	UBERON:0000922	denotes	embryonic
T7915	2024-2029	GO:0007567	denotes	natal
T7916	2030-2034	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T7917	2177-2181	UBERON:0001037	denotes	hair
T7918	2220-2231	CL:0000148	denotes	melanocytes
T7919	2382-2386	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T7920	2396-2400	NCBITaxon:10088	denotes	mice
T7921	2467-2474	CHEBI_EXT:26130	denotes	pigment
T7922	2494-2501	CHEBI_EXT:26130	denotes	pigment
T7923	2556-2561	UBERON:0000180	denotes	flank
T7924	2600-2606	PR_EXT:000004372	denotes	Agouti
T7925	2607-2611	CHEBI_SO_EXT:mRNA	denotes	mRNA
T7926	2646-2653	UBERON:0013235	denotes	ventrum
T7927	2659-2663	UBERON:0001037	denotes	hair
T7928	2664-2671	CHEBI_EXT:26130	denotes	pigment
T7929	2737-2744	UBERON:0013235	denotes	ventrum
T7930	2772-2779	SO_EXT:0000704	denotes	genetic
T7931	2842-2847	UBERON:0000180	denotes	flank
T7932	4120-4125	PR_EXT:000016145	denotes	Tbx15
T7933	4162-4166	UBERON:0001037	denotes	hair
T7934	4175-4182	CHEBI_EXT:26130	denotes	pigment
T7935	4196-4206	GO:0010467	denotes	expression
T7936	4231-4237	PR_EXT:000004372	denotes	Agouti
T7937	4238-4245	SO_EXT:0001060	denotes	isoform
T7938	4340-4352	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T7939	4356-4361	UBERON:0007023	denotes	adult
T7940	4370-4374	NCBITaxon:10088	denotes	mice
T7941	4419-4423	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T7942	4427-4435	PATO_UBERON_EXT:neonate_or_newborn	denotes	neonatal
T7943	4444-4448	NCBITaxon:10088	denotes	mice
T7944	4496-4502	UBERON:0007023	denotes	adults
T7945	4569-4573	UBERON:0001037	denotes	hair
T8391	4588-4596	OBI_SO_EXT:gene_or_genetic_investigation_or_genetic_process	denotes	Genetics
T8392	4600-4605	PR_EXT:000016145	denotes	Tbx15
T8393	4634-4637	CHEBI_SO_EXT:DNA	denotes	DNA
T8394	4638-4645	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T8395	4646-4652	SO_EXT:0000417	denotes	domain
T8396	4677-4682	NCBITaxon:10088	denotes	mouse
T8397	4683-4692	PR_EXT:000016001	denotes	Brachyury
T8398	4693-4697	SO_EXT:0000704	denotes	gene
T8399	4733-4737	UBERON:0002415	denotes	tail
T8400	4757-4762	SO_EXT:0000704	denotes	genes
T8401	4801-4811	GO_EXT:regulator	denotes	regulators
T8402	4834-4841	UBERON:0000479	denotes	tissues
T8403	4846-4869	UBERON:0000468	denotes	multicellular organisms
T8404	4851-4859	CL_GO_EXT:cell	denotes	cellular
T8405	4860-4869	NCBITaxon:1	denotes	organisms
T8406	4906-4911	PR_EXT:000016145	denotes	Tbx15
T8407	4943-4948	PR_EXT:000016146	denotes	Tbx18
T8408	4953-4958	PR_EXT:000016150	denotes	Tbx22
T8409	4998-5006	NCBITaxon:7711	denotes	chordate
T8410	5041-5045	SO_EXT:0000704	denotes	gene
T8411	5049-5058	NCBITaxon:7740	denotes	amphioxus
T8412	5074-5081	SO_EXT:0000853	denotes	homolog
T8413	5089-5092	NCBITaxon:7147	denotes	fly
T8414	5093-5099	SO_EXT:0001026	denotes	genome
T8415	5169-5174	SO_EXT:0000704	denotes	genes
T8416	5179-5188	GO:0010467	denotes	expressed
T8417	5245-5252	UBERON:0002329	denotes	somites
T8418	5254-5259	PR_EXT:000016146	denotes	Tbx18
T8419	5264-5269	PR_EXT:000016150	denotes	Tbx22
T8420	5272-5287	UBERON:0009749	denotes	limb mesenchyme
T8421	5289-5294	PR_EXT:000016145	denotes	Tbx15
T8422	5299-5304	PR_EXT:000016146	denotes	Tbx18
T8423	5311-5323	UBERON_EXT:face_or_skull	denotes	craniofacial
T8424	5324-5334	UBERON:0003104	denotes	mesenchyme
T8425	5346-5351	SO_EXT:0000704	denotes	genes
T8426	5353-5358	PR_EXT:000016145	denotes	Tbx15
T8427	5377-5382	PR_EXT:000016146	denotes	Tbx18
T8428	5386-5391	PR_EXT:000016150	denotes	Tbx22
T8429	5539-5543	SO_EXT:0000704	denotes	gene
T8430	5548-5553	PR_EXT:000016145	denotes	Tbx15
T8431	5555-5560	PR_EXT:000016146	denotes	Tbx18
T8432	5566-5571	PR_EXT:000016150	denotes	Tbx22
T8433	5600-5612	UBERON_EXT:face_or_skull	denotes	craniofacial
T8434	5628-5644	NCBITaxon:7735	denotes	cephalochordates
T8435	5677-5687	GO:0010467	denotes	expression
T8436	5732-5736	UBERON:0002101	denotes	limb
T8437	5745-5750	UBERON:0002100	denotes	trunk
T8438	5764-5774	NCBITaxon:7742	denotes	vertebrate
T8439	5786-5796	GO:0010467	denotes	Expression
T8440	5800-5805	PR_EXT:000016146	denotes	Tbx18
T8441	5810-5815	PR_EXT:000016150	denotes	Tbx22
T8442	5841-5850	UBERON:0000922	denotes	embryonic
T8443	5851-5856	UBERON:0000180	denotes	flank
T8444	5857-5867	UBERON:0003104	denotes	mesenchyme
T8445	5889-5894	PR_EXT:000016145	denotes	Tbx15
T8446	5979-5984	UBERON:0002100	denotes	trunk
T8447	6070-6077	NCBITaxon:33208	denotes	animals
T8448	6078-6085	SO_EXT:sequence_alteration_process	denotes	mutated
T8449	6137-6141	UBERON_EXT:body	denotes	body
T8450	6168-6173	UBERON:0002101	denotes	limbs
T8451	6182-6186	UBERON:0000033	denotes	head
T8452	6201-6210	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T8453	6214-6219	PR_EXT:000016150	denotes	Tbx22
T8454	6230-6235	NCBITaxon:9606	denotes	human
T8455	6245-6246	GO:0000805	denotes	X
T8456	6333-6338	PR_EXT:000016150	denotes	Tbx22
T8457	6339-6349	GO:0010467	denotes	expression
T8458	6353-6363	_FRAGMENT	denotes	periocular
T8459	6374-6384	UBERON:0004017	denotes	mesenchyme
T8460	6364-6373	UBERON:0000922	denotes	embryonic
T8461	6480-6483	UBERON:0000970	denotes	eye
T8462	6534-6539	PR_EXT:000016145	denotes	Tbx15
T8463	6593-6603	GO:0010467	denotes	expression
T8464	6624-6629	NCBITaxon:10088	denotes	mouse
T8465	6630-6635	PR_EXT:000016145	denotes	Tbx15
T8466	6669-6674	NCBITaxon:9606	denotes	human
T8467	6675-6680	PR_EXT:000016145	denotes	Tbx15
T8468	6694-6704	GO_SO_EXT:chromosome	denotes	Chromosome
T8469	6744-6750	UBERON:0001456	denotes	facial
T8470	6826-6836	GO_SO_EXT:chromosome	denotes	Chromosome
T8471	6893-6902	GO:0030849	denotes	autosomal
T8472	6938-6944	UBERON:0001456	denotes	facial
T8473	6961-6967	GO_EXT:biological_growth_entity_or_process	denotes	growth
T8474	6980-6984	UBERON:0000165	denotes	oral
T8475	6985-6991	UBERON:0000344	denotes	mucosa
T8476	7011-7016	UBERON:0002398	denotes	hands
T8477	7347-7356	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T8478	7360-7365	NCBITaxon:9606	denotes	human
T8479	7366-7371	PR_EXT:000016145	denotes	TBX15
T8480	7420-7429	GO:0030849	denotes	autosomal
T8481	7504-7511	UBERON:0004089	denotes	midface
T8482	7614-7622	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T8483	7649-7657	UBERON:0004288	denotes	skeletal
T8484	7649-7669	GO:0001501	denotes	skeletal development
T8485	7731-7735	SO_EXT:0000704	denotes	gene
T8486	7736-7740	PR_EXT:000003979	denotes	Alx3
T8487	7750-7757	SO_EXT:0001023	denotes	allelic
T8488	7770-7773	UBERON:0001690	denotes	ear
T8489	7832-7840	UBERON:0004288	denotes	skeletal
T8490	7863-7867	PR_EXT:000003979	denotes	Alx3
T8491	7871-7875	PR_EXT:000003980	denotes	Alx4
T8492	7876-7883	SO_EXT:sequence_altered_entity	denotes	mutants
T8493	7948-7952	PR_EXT:000003979	denotes	Alx3
T8494	7992-7997	PR_EXT:000016145	denotes	Tbx15
T8495	7998-8006	UBERON:0004288	denotes	skeletal
T9275	8080-8090	GO:0010467	denotes	Expression
T9276	8109-8113	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	Skin
T9277	8143-8148	PR_EXT:000016145	denotes	Tbx15
T9278	8152-8159	CHEBI_EXT:26130	denotes	pigment
T9279	8160-8170	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterning
T9280	8203-8209	PR_EXT:000004372	denotes	Agouti
T9281	8217-8222	GO:0007567	denotes	natal
T9282	8223-8230	NCBITaxon:33208	denotes	animals
T9283	8241-8247	PR_EXT:000004372	denotes	Agouti
T9284	8256-8265	GO:0010467	denotes	expressed
T9285	8273-8279	UBERON:0000922	denotes	embryo
T9286	8312-8318	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T9287	8330-8336	UBERON:0002067	denotes	dermis
T9288	8377-8386	UBERON:0000922	denotes	embryonic
T9289	8387-8393	PR_EXT:000004372	denotes	Agouti
T9290	8394-8404	GO:0010467	denotes	expression
T9291	8416-8423	NCBITaxon:33208	denotes	animals
T9292	8463-8468	PR_EXT:000016145	denotes	Tbx15
T9293	8485-8495	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterning
T9294	8545-8550	SO_EXT:0000704	denotes	genes
T9295	8712-8726	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T9296	8727-8735	_FRAGMENT	denotes	group of
T9297	8746-8751	UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population	denotes	cells
T9298	8746-8751	CL_GO_EXT:cell	denotes	cells
T9299	8798-8824	_FRAGMENT	denotes	proliferative expansion of
T9300	8827-8842	GO:0008283	denotes	cell population
T9301	8827-8831	CL_GO_EXT:cell	denotes	cell
T9302	8827-8842	UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population	denotes	cell population
T9303	8998-9002	NCBITaxon:10088	denotes	mice
T9304	9046-9052	PR_EXT:000004372	denotes	Agouti
T9305	9053-9063	GO:0010467	denotes	expression
T9306	9071-9076	GO:0007567	denotes	natal
T9307	9085-9092	NCBITaxon:33208	denotes	animals
T9308	9186-9195	UBERON:0000922	denotes	embryonic
T9309	9186-9201	CL:0002321	denotes	embryonic cells
T9310	9196-9201	CL_GO_EXT:cell	denotes	cells
T9311	9218-9228	UBERON:0003104	denotes	mesenchyme
T9312	9289-9294	CL_GO_EXT:cell	denotes	cells
T9313	9303-9314	GO:0008283	denotes	proliferate
T9314	9371-9376	CL_GO_EXT:cell	denotes	cells
T9315	9378-9382	CL_GO_EXT:cell	denotes	Cell
T9316	9529-9533	UBERON:0001037	denotes	hair
T9317	9551-9555	NCBITaxon:10088	denotes	mice
T9318	9672-9677	UBERON:0000180	denotes	flank
T9319	9704-9713	UBERON:0000922	denotes	embryonic
T9320	9714-9724	UBERON:0003104	denotes	mesenchyme
T9321	9726-9736	GO:0010467	denotes	expression
T9322	9740-9745	PR_EXT:000016145	denotes	Tbx15
T9323	9750-9756	PR_EXT:000004372	denotes	Agouti
T9324	9800-9805	PR_EXT:000016145	denotes	Tbx15
T9325	9831-9837	PR_EXT:000004372	denotes	Agouti
T9326	9838-9851	GO_EXT:transcription	denotes	transcription
T9327	9868-9878	UBERON:0003104	denotes	mesenchyme
T9328	9904-9909	PR_EXT:000016145	denotes	Tbx15
T9329	9922-9932	GO:0010467	denotes	expression
T9330	9957-9963	PR_EXT:000004372	denotes	Agouti
T9331	9964-9971	SO_EXT:0001060	denotes	isoform
T9332	9979-9984	GO:0007567	denotes	natal
T9333	9985-9989	NCBITaxon:10088	denotes	mice
T9334	10026-10031	GO:0007567	denotes	natal
T9335	10032-10042	GO:0010467	denotes	expression
T9336	10046-10051	PR_EXT:000016145	denotes	Tbx15
T9337	10133-10139	PR_EXT:000004372	denotes	Agouti
T9338	10172-10177	PR_EXT:000016145	denotes	Tbx15
T9339	10192-10196	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T9340	10205-10210	SO_EXT:0000704	denotes	genes
T9341	10226-10232	PR_EXT:000004372	denotes	Agouti
T9342	10240-10244	UBERON:0001037	denotes	hair
T9343	10240-10244	_FRAGMENT	denotes	hair
T9344	10256-10266	CL:0002483	denotes	melanocyte
T9345	10333-10340	NCBITaxon:33208	denotes	animals
T9346	10354-10358	SO_EXT:sequence_nullness	denotes	null
T9347	10359-10365	PR_EXT:000004372	denotes	Agouti
T9348	10366-10372	SO_EXT:0001023	denotes	allele
T9349	10398-10402	PR_EXT:000003980	denotes	Alx4
T9350	10416-10422	PR_EXT:000004372	denotes	Agouti
T9351	10427-10436	GO:0010467	denotes	expressed
T9352	10448-10457	UBERON:0000922	denotes	embryonic
T9353	10458-10468	UBERON:0003104	denotes	mesenchyme
T9354	10480-10487	SO_EXT:sequence_alteration_process	denotes	mutated
T9355	10497-10510	UBERON:0002073	denotes	hair-follicle
T9356	10522-10526	UBERON:0002101	denotes	limb
T9357	10522-10526	_FRAGMENT	denotes	limb
T9358	10544-10555	GO:0060173	denotes	development
T9359	10531-10543	UBERON_EXT:face_or_skull	denotes	craniofacial
T9360	10650-10660	GO:0010467	denotes	expression
T9361	10672-10679	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T9362	10688-10692	PR_EXT:000003980	denotes	Alx4
T9363	10705-10709	PR_EXT:000003979	denotes	Alx3
T9364	10714-10718	PR_EXT:000010687	denotes	Msx2
T9365	10765-10772	UBERON:0000922	denotes	embryos
T10075	10837-10841	UBERON:0002101	denotes	Limb
T10076	10842-10852	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	Patterning
T10077	10861-10866	PR_EXT:000016145	denotes	Tbx15
T10078	10905-10909	UBERON:0001037	denotes	hair
T10079	10923-10928	UBERON:0002101	denotes	limbs
T10080	10975-10979	UBERON:0001037	denotes	hair
T10081	11002-11006	UBERON:0001037	denotes	hair
T10082	11052-11059	CHEBI_EXT:26130	denotes	pigment
T10083	11082-11086	UBERON:0002101	denotes	limb
T10084	11119-11123	NCBITaxon:10088	denotes	mice
T10085	11210-11213	PR_EXT:000007070	denotes	En1
T10086	11217-11222	PR_EXT:000017448	denotes	Wnt7a
T10087	11275-11279	UBERON:0002101	denotes	limb
T10088	11285-11291	UBERON:0001137	denotes	dorsum
T10089	11295-11302	UBERON:0013235	denotes	ventrum
T10090	11327-11334	UBERON:0013235	denotes	ventrum
T10091	11338-11344	UBERON:0001137	denotes	dorsum
T10092	11423-11429	PR_EXT:000004372	denotes	Agouti
T10093	11430-11440	GO:0010467	denotes	expression
T10094	11460-11464	UBERON:0001037	denotes	hair
T10095	11517-11529	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T10096	11545-11553	UBERON:0013623	denotes	footpads
T10097	11571-11574	PR_EXT:000007070	denotes	En1
T10098	11575-11581	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T10099	11582-11586	NCBITaxon:10088	denotes	mice
T10100	11603-11610	CHEBI_EXT:26130	denotes	pigment
T10101	11672-11675	PR_EXT:000007070	denotes	En1
T10102	11692-11697	PR_EXT:000017448	denotes	Wnt7a
T10103	11710-11719	_FRAGMENT	denotes	migration
T10104	11747-11749	_FRAGMENT	denotes	of
T10105	11758-11763	GO:0016477	denotes	cells
T10106	11723-11736	_FRAGMENT	denotes	proliferation
T10107	11758-11763	GO:0008283	denotes	cells
T10108	11750-11757	CHEBI_EXT:26130	denotes	pigment
T10109	11750-11763	CL:0000147	denotes	pigment cells
T10110	11758-11763	CL_GO_EXT:cell	denotes	cells
T10111	11775-11784	UBERON:0007376	denotes	epidermis
T10112	11865-11872	GO:0065007	denotes	control
T10113	11889-11894	UBERON:0002100	denotes	trunk
T10114	11906-11911	PR_EXT:000016145	denotes	Tbx15
T10115	11941-11948	GO:0065007	denotes	control
T10116	11965-11969	UBERON:0002101	denotes	limb
T10117	11970-11980	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterning
T10118	11984-11989	PR_EXT:000009871	denotes	Lmx1b
T10119	11997-12003	SO_EXT:0000417	denotes	domain
T10120	12004-12017	GO_EXT:transcription	denotes	transcription
T10121	12004-12024	GO_EXT:transcription_factor	denotes	transcription factor
T10122	12049-12054	PR_EXT:000017448	denotes	Wnt7a
T10123	12059-12062	PR_EXT:000007070	denotes	En1
T10124	12190-12195	PR_EXT:000016145	denotes	Tbx15
T10125	12200-12205	PR_EXT:000009871	denotes	Lmx1b
T10126	12226-12237	UBERON:0003104	denotes	mesenchymal
T10127	12226-12243	CL:0000134	denotes	mesenchymal cells
T10128	12238-12243	CL_GO_EXT:cell	denotes	cells
T10129	12283-12293	GO:0010467	denotes	expression
T10130	12328-12332	CL_GO_EXT:cell	denotes	cell
T10131	12361-12366	UBERON:0000180	denotes	flank
T10132	12368-12373	PR_EXT:000016145	denotes	Tbx15
T10133	12382-12386	UBERON:0002101	denotes	limb
T10134	12388-12393	PR_EXT:000009871	denotes	Lmx1b
T10135	12454-12459	PR_EXT:000009871	denotes	Lmx1b
T10136	12465-12475	GO:0010467	denotes	expression
T10137	12490-12494	UBERON:0002101	denotes	limb
T10138	12506-12511	PR_EXT:000017448	denotes	Wnt7a
T10139	12545-12553	UBERON:0000924	denotes	ectoderm
T10140	12615-12620	PR_EXT:000017448	denotes	Wnt7a
T10141	12655-12663	UBERON:0000924	denotes	ectoderm
T10142	12667-12670	PR_EXT:000007070	denotes	En1
T10143	12686-12694	UBERON:0000924	denotes	ectoderm
T10144	12761-12771	GO:0010467	denotes	expression
T10145	12772-12777	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	marks
T10146	12845-12868	UBERON:0004356	denotes	apical ectodermal ridge
T10147	12953-12956	PR_EXT:000007070	denotes	En1
T10148	12960-12965	PR_EXT:000017448	denotes	Wnt7a
T10149	12966-12975	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T10150	13021-13025	UBERON:0001037	denotes	hair
T10151	13159-13169	UBERON:0000924	denotes	ectodermal
T10152	13191-13198	GO:0065007	denotes	control
T10153	13222-13232	UBERON:0003104	denotes	mesenchyme
T10154	13247-13252	UBERON:0002101	denotes	limbs
T10155	13270-13275	UBERON:0002100	denotes	trunk
T10156	13291-13295	UBERON:0002101	denotes	limb
T10157	13301-13315	UBERON:0001911	denotes	mammary glands
T10158	13382-13392	UBERON:0000483	denotes	epithelial
T10159	13393-13404	UBERON:0003104	denotes	mesenchymal
T10160	13468-13482	UBERON:0001911	denotes	mammary glands
T10161	13505-13512	NCBITaxon:33208	denotes	animals
T10162	13569-13576	GO:0065007	denotes	control
T10163	13590-13600	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterning
T10164	13608-13613	UBERON:0002100	denotes	trunk
T10165	13632-13637	UBERON:0002101	denotes	limbs
T10166	13742-13754	UBERON:0011270	denotes	dorsal trunk
T10167	13755-13763	UBERON:0000924	denotes	ectoderm
T10168	13796-13806	GO:0010467	denotes	expression
T10169	13810-13815	PR_EXT:000016145	denotes	Tbx15
T10170	13819-13831	UBERON:0011270	denotes	dorsal trunk
T10171	13832-13842	UBERON:0003104	denotes	mesenchyme
T10172	13903-13908	CL_GO_EXT:cell	denotes	cells
T10173	13941-13947	PR_EXT:000004372	denotes	Agouti
T10174	13948-13958	GO:0010467	denotes	expression
T10175	13960-13967	CHEBI_EXT:26130	denotes	pigment
T10176	13960-13972	CL:0000147	denotes	pigment-cell
T10177	13960-13984	GO:0070285	denotes	pigment-cell development
T10178	13968-13972	CL_GO_EXT:cell	denotes	cell
T10179	13990-13994	UBERON:0001037	denotes	hair
T10180	13995-14001	GO_EXT:biological_growth_entity_or_process	denotes	growth
T10181	14032-14037	PR_EXT:000016145	denotes	Tbx15
T10182	14038-14048	GO:0010467	denotes	expression
T10183	14084-14087	PR_EXT:000007070	denotes	En1
T10184	14088-14098	GO:0010467	denotes	expression
T10185	14138-14150	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T10186	14200-14208	UBERON:0004347	denotes	limb-bud
T10187	14283-14288	UBERON:0002100	denotes	trunk
T10188	14289-14297	UBERON:0000924	denotes	ectoderm
T10189	14321-14325	UBERON:0002101	denotes	limb
T10190	14394-14399	NCBITaxon_UBERON_EXT:chick	denotes	chick
T10191	14466-14474	UBERON:0000924	denotes	ectoderm
T10192	14487-14491	UBERON:0002101	denotes	limb
T10193	14570-14574	UBERON:0002101	denotes	limb
T10194	14624-14628	UBERON:0002101	denotes	limb
T10195	14629-14637	UBERON:0000926	denotes	mesoderm
T10196	14755-14760	UBERON:0002101	denotes	limbs
T10197	14769-14792	UBERON:0004356	denotes	apical ectodermal ridge
T10198	14809-14819	GO:0010467	denotes	expression
T10199	14823-14828	PR_EXT:000016145	denotes	Tbx15
T10200	14836-14841	UBERON:0002100	denotes	trunk
T10201	14857-14862	UBERON:0002101	denotes	limbs
T10202	14883-14887	UBERON:0002101	denotes	limb
T10203	14982-14991	UBERON:0004347	denotes	limb buds
T10204	15008-15020	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T10205	15151-15161	GO:0010467	denotes	expression
T10206	15165-15170	PR_EXT:000016145	denotes	Tbx15
T10207	15174-15192	UBERON:2000164	denotes	ventral mesenchyme
T10208	15226-15238	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T10209	15312-15317	PR_EXT:000016145	denotes	Tbx15
T10210	15318-15328	GO:0010467	denotes	expression
T10211	15373-15381	UBERON:0000926	denotes	mesoderm
T10212	15428-15433	PR_EXT:000016145	denotes	Tbx15
T10213	15445-15449	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T10214	15450-15460	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterning
T10215	15516-15548	GO:0048263	denotes	establishment of dorsal identity
T10216	15552-15557	PR_EXT:000016145	denotes	Tbx15
T10217	15633-15643	UBERON:0003104	denotes	mesenchyme
T10218	15662-15670	UBERON:0000924	denotes	ectoderm
T11236	15673-15685	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	Pigmentation
T11237	15699-15704	PR_EXT:000016145	denotes	Tbx15
T11238	15714-15721	NCBITaxon:40674	denotes	Mammals
T11239	15734-15750	UBERON:0015178	denotes	somitic frontier
T11240	15792-15798	UBERON:0002329	denotes	somite
T11241	15814-15827	UBERON:0003081	denotes	lateral plate
T11242	15836-15844	UBERON:0000926	denotes	mesoderm
T11243	15868-15881	GO_EXT:somite_development_or_somitogenesis	denotes	somitogenesis
T11244	16017-16022	GO:0007567	denotes	natal
T11245	16023-16030	NCBITaxon:33208	denotes	animals
T11246	16067-16071	CL_GO_EXT:cell	denotes	cell
T11247	16178-16194	UBERON:0015178	denotes	somitic frontier
T11248	16214-16226	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T11249	16290-16294	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T11250	16401-16405	PR_EXT:000010686	denotes	Msx1
T11251	16413-16423	GO:0010467	denotes	expression
T11252	16424-16429	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	marks
T11253	16444-16450	UBERON:0002329	denotes	somite
T11254	16459-16470	UBERON:0003104	denotes	mesenchymal
T11255	16459-16476	CL:0000134	denotes	mesenchymal cells
T11256	16471-16476	CL_GO_EXT:cell	denotes	cells
T11257	16496-16502	UBERON:0002067	denotes	dermis
T11258	16515-16521	UBERON:2001463	denotes	stripe
T11259	16637-16642	GO:0007567	denotes	natal
T11260	16643-16652	NCBITaxon:40674	denotes	mammalian
T11261	16653-16657	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T11262	16724-16731	CHEBI_EXT:26130	denotes	pigment
T11263	16763-16767	CL_GO_EXT:cell	denotes	cell
T11264	16796-16806	GO:0010467	denotes	expression
T11265	16810-16814	PR_EXT:000010686	denotes	Msx1
T11266	16819-16826	NCBITaxon:9989	denotes	rodents
T11267	16837-16849	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T11268	16891-16898	NCBITaxon:40674	denotes	mammals
T11269	16933-16937	UBERON:0001037	denotes	hair
T11270	17004-17012	NCBITaxon:9654	denotes	Raccoons
T11271	17014-17023	NCBITaxon:55153	denotes	squirrels
T11272	17025-17031	NCBITaxon:119825	denotes	skunks
T11273	17052-17061	NCBITaxon_EXT:ungulate	denotes	ungulates
T11274	17078-17085	UBERON:2001463	denotes	stripes
T11275	17176-17192	UBERON:0015178	denotes	somitic frontier
T11276	17209-17213	PR_EXT:000010686	denotes	Msx1
T11277	17282-17287	PR_EXT:000016145	denotes	Tbx15
T11278	17291-17303	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T11279	17318-17322	NCBITaxon:10088	denotes	mice
T11280	17341-17345	UBERON:0010166	denotes	coat
T11281	17411-17418	NCBITaxon:40674	denotes	mammals
T11282	17427-17435	UBERON:2002284	denotes	markings
T11283	17455-17458	NCBITaxon:9615	denotes	dog
T11284	17523-17544	NCBITaxon:42413	denotes	Peromyscus polionotus
T11285	17587-17599	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T11286	17634-17644	NCBITaxon:subspecies	denotes	subspecies
T11287	17753-17762	NCBITaxon:10040	denotes	deer mice
T11288	17768-17780	UBERON_EXT:face_or_skull	denotes	craniofacial
T11289	17816-17824	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T11290	17834-17846	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T11291	17865-17872	NCBITaxon:33208	denotes	animals
T11292	17908-17918	GO:0065007	denotes	regulation
T11293	17932-17937	PR_EXT:000016145	denotes	Tbx15
T11294	17994-17999	PR_EXT:000016145	denotes	Tbx15
T11295	18003-18007	UBERON:0010166	denotes	coat
T11296	18043-18050	SO_EXT:0000704	denotes	genetic
T11297	18096-18103	NCBITaxon:40674	denotes	mammals
T11298	18127-18139	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T11299	18163-18171	SO_EXT:biological_sequence	denotes	sequence
T11300	18176-18186	GO:0010467	denotes	expression
T11301	18190-18195	PR_EXT:000016145	denotes	Tbx15
T11302	18205-18216	NCBITaxon:7742	denotes	vertebrates
T11303	18278-18286	UBERON:0004288	denotes	skeleton
T11304	18302-18312	CHEBI_EXT:26130	denotes	pigmentary
T9274	8074-8079	PR_EXT:000016145	denotes	Tbx15
R5786	T8459	T8458	_lexicallyChainedTo	mesenchyme,periocular
R6402	T9297	T9296	_lexicallyChainedTo	cells,group of
R6403	T9300	T9299	_lexicallyChainedTo	cell population,proliferative expansion of
R6404	T9344	T9343	_lexicallyChainedTo	melanocyte,hair
R6405	T9358	T9357	_lexicallyChainedTo	development,limb
R6892	T10104	T10103	_lexicallyChainedTo	of,migration
R6893	T10104	T10106	_lexicallyChainedTo	of,proliferation
R6894	T10105	T10104	_lexicallyChainedTo	cells,of
R6895	T10107	T10104	_lexicallyChainedTo	cells,of

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PMC:314463 / 36755-55075 JSON TXT