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Id Subject Object Predicate Lexical cue
T4613 0-10 JJ denotes Positional
T4614 11-18 NN denotes Cloning
T4615 19-21 IN denotes of
T4616 22-25 NN denotes deH
T4617 25-311 sentence denotes As a visible marker, early linkage studies with the original droopy ear allele or the deH allele identified a map position in the middle of Chromosome 3, distal to matted and proximal to Varitint-waddler (Carter and Falconer 1951; Curry 1959; Lane and Eicher 1979; Holmes et al. 1981).
T4618 26-28 IN denotes As
T4619 123-133 VBD denotes identified
T4620 29-30 DT denotes a
T4621 39-45 NN denotes marker
T4622 31-38 JJ denotes visible
T4623 45-47 , denotes ,
T4624 47-52 JJ denotes early
T4625 61-68 NNS denotes studies
T4626 53-60 NN denotes linkage
T4627 69-73 IN denotes with
T4628 74-77 DT denotes the
T4629 98-104 NN denotes allele
T4630 78-86 JJ denotes original
T4631 87-93 JJ denotes droopy
T4632 94-97 NN denotes ear
T4633 105-107 CC denotes or
T4634 108-111 DT denotes the
T4635 116-122 NN denotes allele
T4636 112-115 NN denotes deH
T4637 134-135 DT denotes a
T4638 140-148 NN denotes position
T4639 136-139 NN denotes map
T4640 149-151 IN denotes in
T4641 152-155 DT denotes the
T4642 156-162 NN denotes middle
T4643 163-165 IN denotes of
T4644 166-176 NN denotes Chromosome
T4645 177-178 CD denotes 3
T4646 178-180 , denotes ,
T4647 180-186 JJ denotes distal
T4648 187-189 IN denotes to
T4649 190-196 JJ denotes matted
T4650 197-200 CC denotes and
T4651 201-209 JJ denotes proximal
T4652 210-212 IN denotes to
T4653 213-221 NNP denotes Varitint
T4654 222-229 NNP denotes waddler
T4655 221-222 HYPH denotes -
T4656 230-231 -LRB- denotes (
T4657 231-237 NNP denotes Carter
T4658 238-241 CC denotes and
T4659 242-250 NNP denotes Falconer
T4660 251-255 CD denotes 1951
T4661 255-256 : denotes ;
T4662 257-262 NNP denotes Curry
T4663 263-267 CD denotes 1959
T4664 267-268 : denotes ;
T4665 269-273 NNP denotes Lane
T4666 274-277 CC denotes and
T4667 278-284 NNP denotes Eicher
T4668 285-289 CD denotes 1979
T4669 289-290 : denotes ;
T4670 291-297 NNP denotes Holmes
T4671 298-300 FW denotes et
T4672 301-304 FW denotes al.
T4673 305-309 CD denotes 1981
T4674 309-310 -RRB- denotes )
T4675 310-311 . denotes .
T4676 311-610 sentence denotes We used an F2 intercross with CAST/Ei mice to localize deH to a 0.1 cM interval between D3Mit213 and 16.MMHAP32FLF1, which was refined by development of a bacterial artificial chromosome (BAC) contig and additional markers to a 1.4 Mb region that contained eight genes, including Tbx15 (Figure 3A).
T4677 312-314 PRP denotes We
T4678 315-319 VBD denotes used
T4679 320-322 DT denotes an
T4680 326-336 NN denotes intercross
T4681 323-325 NN denotes F2
T4682 337-341 IN denotes with
T4683 342-346 NN denotes CAST
T4684 347-349 NN denotes Ei
T4685 346-347 HYPH denotes /
T4686 350-354 NNS denotes mice
T4687 355-357 TO denotes to
T4688 358-366 VB denotes localize
T4689 367-370 NN denotes deH
T4690 371-373 IN denotes to
T4691 374-375 DT denotes a
T4692 383-391 NN denotes interval
T4693 376-379 CD denotes 0.1
T4694 380-382 NN denotes cM
T4695 392-399 IN denotes between
T4696 400-408 NN denotes D3Mit213
T4697 409-412 CC denotes and
T4698 413-427 NN denotes 16.MMHAP32FLF1
T4699 427-429 , denotes ,
T4700 429-434 WDT denotes which
T4701 439-446 VBN denotes refined
T4702 435-438 VBD denotes was
T4703 447-449 IN denotes by
T4704 450-461 NN denotes development
T4705 462-464 IN denotes of
T4706 465-466 DT denotes a
T4707 505-511 NN denotes contig
T4708 467-476 JJ denotes bacterial
T4709 488-498 NN denotes chromosome
T4710 477-487 JJ denotes artificial
T4711 499-500 -LRB- denotes (
T4712 500-503 NN denotes BAC
T4713 503-504 -RRB- denotes )
T4714 512-515 CC denotes and
T4715 516-526 JJ denotes additional
T4716 527-534 NNS denotes markers
T4717 535-537 IN denotes to
T4718 538-539 DT denotes a
T4719 547-553 NN denotes region
T4720 540-543 CD denotes 1.4
T4721 544-546 NN denotes Mb
T4722 554-558 WDT denotes that
T4723 559-568 VBD denotes contained
T4724 569-574 CD denotes eight
T4725 575-580 NNS denotes genes
T4726 580-582 , denotes ,
T4727 582-591 VBG denotes including
T4728 592-597 NN denotes Tbx15
T4729 598-599 -LRB- denotes (
T4730 599-605 NN denotes Figure
T4731 606-608 CD denotes 3A
T4732 608-609 -RRB- denotes )
T4733 609-610 . denotes .
T4734 610-833 sentence denotes We considered Tbx15 as an excellent candidate for the skeletal abnormalities caused by deH, based on studies by Agulnik et al. (1998), who described its embryonic expression in the craniofacial region and developing limbs.
T4735 611-613 PRP denotes We
T4736 614-624 VBD denotes considered
T4737 625-630 NN denotes Tbx15
T4738 631-633 IN denotes as
T4739 634-636 DT denotes an
T4740 647-656 NN denotes candidate
T4741 637-646 JJ denotes excellent
T4742 657-660 IN denotes for
T4743 661-664 DT denotes the
T4744 674-687 NNS denotes abnormalities
T4745 665-673 JJ denotes skeletal
T4746 688-694 VBN denotes caused
T4747 695-697 IN denotes by
T4748 698-701 NN denotes deH
T4749 701-703 , denotes ,
T4750 703-708 VBN denotes based
T4751 709-711 IN denotes on
T4752 712-719 NNS denotes studies
T4753 720-722 IN denotes by
T4754 723-730 NNP denotes Agulnik
T4755 731-733 FW denotes et
T4756 734-737 FW denotes al.
T4757 738-739 -LRB- denotes (
T4758 739-743 CD denotes 1998
T4759 743-744 -RRB- denotes )
T4760 744-746 , denotes ,
T4761 746-749 WP denotes who
T4762 750-759 VBD denotes described
T4763 760-763 PRP$ denotes its
T4764 774-784 NN denotes expression
T4765 764-773 JJ denotes embryonic
T4766 785-787 IN denotes in
T4767 788-791 DT denotes the
T4768 805-811 NN denotes region
T4769 792-804 JJ denotes craniofacial
T4770 812-815 CC denotes and
T4771 816-826 VBG denotes developing
T4772 827-832 NNS denotes limbs
T4773 832-833 . denotes .
T4774 833-1968 sentence denotes Figure 3 Molecular Genetics of deH and Tbx15 (A) Genetic and physical map, as described in the text. Markers M1 to M3 are SSCP markers generated from a BAC contig of the region; marker M4 is STS 16.MMHAP32FLF1 and was also used as an SSCP marker. M2 and M3, which flank the Tbx15 and M6pr-ps on the UCSC genome browser map and lie 634 kb apart, were nonrecombinant with deH in 2340 meioses. (B) The deH mutation is a deletion that starts in Tbx15 intron 1 and ends in the M6pr-ps. (C) Sequence of deletion breakpoints. (D) Diagram of Tbx15LacZ allele constructed by gene targeting. As described in the text, this allele is predicted to give rise to a protein truncated after approximately 154 codons and is lacking critical residues of the T box. Heterozygotes for the targeted allele exhibit normal size, morphology, and hair-color patterns, but homozygotes and Tbx15LacZ/deH compound heterozygotes are identical to deH homozygotes. Using sequence information from Agulnik et al. (1998) and the partially completed mouse genome sequence, we found that portions of several Tbx15 exons could not be amplified from deH/deH genomic DNA.
T4775 1769-1774 VBG denotes Using
T4776 1877-1882 VBD denotes found
T4777 1775-1783 NN denotes sequence
T4778 1784-1795 NN denotes information
T4779 1796-1800 IN denotes from
T4780 1801-1808 NNP denotes Agulnik
T4781 1809-1811 FW denotes et
T4782 1812-1815 FW denotes al.
T4783 1816-1817 -LRB- denotes (
T4784 1817-1821 CD denotes 1998
T4785 1821-1822 -RRB- denotes )
T4786 1823-1826 CC denotes and
T4787 1827-1830 DT denotes the
T4788 1864-1872 NN denotes sequence
T4789 1831-1840 RB denotes partially
T4790 1841-1850 VBN denotes completed
T4791 1851-1856 NN denotes mouse
T4792 1857-1863 NN denotes genome
T4793 1872-1874 , denotes ,
T4794 1874-1876 PRP denotes we
T4795 1883-1887 IN denotes that
T4796 1933-1942 VBN denotes amplified
T4797 1888-1896 NNS denotes portions
T4798 1897-1899 IN denotes of
T4799 1900-1907 JJ denotes several
T4800 1914-1919 NNS denotes exons
T4801 1908-1913 NN denotes Tbx15
T4802 1920-1925 MD denotes could
T4803 1926-1929 RB denotes not
T4804 1930-1932 VB denotes be
T4805 1943-1947 IN denotes from
T4806 1948-1951 NN denotes deH
T4807 1952-1955 NN denotes deH
T4808 1951-1952 HYPH denotes /
T4809 1964-1967 NN denotes DNA
T4810 1956-1963 JJ denotes genomic
T4811 1967-1968 . denotes .
T4812 1968-2181 sentence denotes The same gene was initially referred to as Tbx8 (Wattler et al. 1998) and then later renamed Tbx14, but is currently referred to in several vertebrate genomes as Tbx15 (Agulnik et al. 1998; Begemann et al. 2002).
T4813 1969-1972 DT denotes The
T4814 1978-1982 NN denotes gene
T4815 1973-1977 JJ denotes same
T4816 1997-2005 VBN denotes referred
T4817 1983-1986 VBD denotes was
T4818 1987-1996 RB denotes initially
T4819 2006-2008 IN denotes to
T4820 2009-2011 IN denotes as
T4821 2012-2016 NN denotes Tbx8
T4822 2017-2018 -LRB- denotes (
T4823 2018-2025 NNP denotes Wattler
T4824 2026-2028 FW denotes et
T4825 2029-2032 FW denotes al.
T4826 2033-2037 CD denotes 1998
T4827 2037-2038 -RRB- denotes )
T4828 2039-2042 CC denotes and
T4829 2043-2047 RB denotes then
T4830 2054-2061 VBN denotes renamed
T4831 2048-2053 RB denotes later
T4832 2062-2067 NN denotes Tbx14
T4833 2067-2069 , denotes ,
T4834 2069-2072 CC denotes but
T4835 2073-2075 VBZ denotes is
T4836 2086-2094 VBN denotes referred
T4837 2076-2085 RB denotes currently
T4838 2095-2097 IN denotes to
T4839 2098-2100 IN denotes in
T4840 2101-2108 JJ denotes several
T4841 2120-2127 NNS denotes genomes
T4842 2109-2119 NN denotes vertebrate
T4843 2128-2130 IN denotes as
T4844 2131-2136 NN denotes Tbx15
T4845 2137-2138 -LRB- denotes (
T4846 2138-2145 NNP denotes Agulnik
T4847 2146-2148 FW denotes et
T4848 2149-2152 FW denotes al.
T4849 2153-2157 CD denotes 1998
T4850 2157-2158 : denotes ;
T4851 2159-2167 NNP denotes Begemann
T4852 2168-2170 FW denotes et
T4853 2171-2174 FW denotes al.
T4854 2175-2179 CD denotes 2002
T4855 2179-2180 -RRB- denotes )
T4856 2180-2181 . denotes .
T4857 2181-2531 sentence denotes By comparing the sequence of a 1.3 kb junction fragment amplified from deH/deH genomic DNA to publicly available mouse genome sequence, we identified a 216 kb deletion that extends from Tbx15 intron 1 to 148 kb downstream of the polyadenylation sequence in a region annotated as a mannose-6-phosphate receptor pseudogene, M6pr-ps (Figure 3B and 3C).
T4858 2182-2184 IN denotes By
T4859 2321-2331 VBD denotes identified
T4860 2185-2194 VBG denotes comparing
T4861 2195-2198 DT denotes the
T4862 2199-2207 NN denotes sequence
T4863 2208-2210 IN denotes of
T4864 2211-2212 DT denotes a
T4865 2229-2237 NN denotes fragment
T4866 2213-2216 CD denotes 1.3
T4867 2217-2219 NN denotes kb
T4868 2220-2228 NN denotes junction
T4869 2238-2247 VBN denotes amplified
T4870 2248-2252 IN denotes from
T4871 2253-2256 NN denotes deH
T4872 2257-2260 NN denotes deH
T4873 2256-2257 HYPH denotes /
T4874 2269-2272 NN denotes DNA
T4875 2261-2268 JJ denotes genomic
T4876 2273-2275 IN denotes to
T4877 2276-2284 RB denotes publicly
T4878 2285-2294 JJ denotes available
T4879 2308-2316 NN denotes sequence
T4880 2295-2300 NN denotes mouse
T4881 2301-2307 NN denotes genome
T4882 2316-2318 , denotes ,
T4883 2318-2320 PRP denotes we
T4884 2332-2333 DT denotes a
T4885 2341-2349 NN denotes deletion
T4886 2334-2337 CD denotes 216
T4887 2338-2340 NN denotes kb
T4888 2350-2354 WDT denotes that
T4889 2355-2362 VBZ denotes extends
T4890 2363-2367 IN denotes from
T4891 2368-2373 NN denotes Tbx15
T4892 2374-2380 NN denotes intron
T4893 2381-2382 CD denotes 1
T4894 2383-2385 IN denotes to
T4895 2386-2389 CD denotes 148
T4896 2390-2392 NN denotes kb
T4897 2393-2403 RB denotes downstream
T4898 2404-2406 IN denotes of
T4899 2407-2410 DT denotes the
T4900 2427-2435 NN denotes sequence
T4901 2411-2426 NN denotes polyadenylation
T4902 2436-2438 IN denotes in
T4903 2439-2440 DT denotes a
T4904 2441-2447 NN denotes region
T4905 2448-2457 VBN denotes annotated
T4906 2458-2460 IN denotes as
T4907 2461-2462 DT denotes a
T4908 2492-2502 NN denotes pseudogene
T4909 2463-2470 NN denotes mannose
T4910 2473-2482 NN denotes phosphate
T4911 2470-2471 HYPH denotes -
T4912 2471-2472 CD denotes 6
T4913 2472-2473 HYPH denotes -
T4914 2483-2491 NN denotes receptor
T4915 2502-2504 , denotes ,
T4916 2504-2508 NN denotes M6pr
T4917 2509-2511 NN denotes ps
T4918 2508-2509 HYPH denotes -
T4919 2512-2513 -LRB- denotes (
T4920 2520-2522 CD denotes 3B
T4921 2513-2519 NN denotes Figure
T4922 2523-2526 CC denotes and
T4923 2527-2529 CD denotes 3C
T4924 2529-2530 -RRB- denotes )
T4925 2530-2531 . denotes .
T4926 2531-2553 sentence denotes (Ludwig et al. 1992).
T4927 2532-2533 -LRB- denotes (
T4928 2533-2539 NNP denotes Ludwig
T4929 2540-2542 FW denotes et
T4930 2543-2546 FW denotes al.
T4931 2547-2551 CD denotes 1992
T4932 2551-2552 -RRB- denotes )
T4933 2552-2553 . denotes .
T4934 2553-2665 sentence denotes By Northern blot analysis, we identified a fusion transcript produced from the deH chromosome (data not shown).
T4935 2554-2556 IN denotes By
T4936 2584-2594 VBD denotes identified
T4937 2557-2565 NNP denotes Northern
T4938 2566-2570 NN denotes blot
T4939 2571-2579 NN denotes analysis
T4940 2579-2581 , denotes ,
T4941 2581-2583 PRP denotes we
T4942 2595-2596 DT denotes a
T4943 2604-2614 NN denotes transcript
T4944 2597-2603 NN denotes fusion
T4945 2615-2623 VBN denotes produced
T4946 2624-2628 IN denotes from
T4947 2629-2632 DT denotes the
T4948 2637-2647 NN denotes chromosome
T4949 2633-2636 NN denotes deH
T4950 2648-2649 -LRB- denotes (
T4951 2658-2663 VBN denotes shown
T4952 2649-2653 NNS denotes data
T4953 2654-2657 RB denotes not
T4954 2663-2664 -RRB- denotes )
T4955 2664-2665 . denotes .
T4956 2665-2908 sentence denotes However, the deletion removes 534 of the 602 amino acids encoded by Tbx15 (including the T-box DNA-binding domain), deH/+ animals are grossly normal, and the phenotype of deH/deH animals is identical to that described for the original allele.
T4957 2666-2673 RB denotes However
T4958 2688-2695 VBZ denotes removes
T4959 2673-2675 , denotes ,
T4960 2675-2678 DT denotes the
T4961 2679-2687 NN denotes deletion
T4962 2696-2699 CD denotes 534
T4963 2707-2710 CD denotes 602
T4964 2700-2702 IN denotes of
T4965 2703-2706 DT denotes the
T4966 2717-2722 NNS denotes acids
T4967 2711-2716 NN denotes amino
T4968 2723-2730 VBN denotes encoded
T4969 2731-2733 IN denotes by
T4970 2734-2739 NN denotes Tbx15
T4971 2740-2741 -LRB- denotes (
T4972 2741-2750 VBG denotes including
T4973 2751-2754 DT denotes the
T4974 2773-2779 NN denotes domain
T4975 2755-2756 NN denotes T
T4976 2757-2760 NN denotes box
T4977 2756-2757 HYPH denotes -
T4978 2761-2764 NN denotes DNA
T4979 2765-2772 VBG denotes binding
T4980 2764-2765 HYPH denotes -
T4981 2779-2780 -RRB- denotes )
T4982 2780-2782 , denotes ,
T4983 2782-2785 NN denotes deH
T4984 2788-2795 NNS denotes animals
T4985 2785-2786 HYPH denotes /
T4986 2786-2787 SYM denotes +
T4987 2796-2799 VBP denotes are
T4988 2800-2807 RB denotes grossly
T4989 2808-2814 JJ denotes normal
T4990 2814-2816 , denotes ,
T4991 2816-2819 CC denotes and
T4992 2820-2823 DT denotes the
T4993 2824-2833 NN denotes phenotype
T4994 2853-2855 VBZ denotes is
T4995 2834-2836 IN denotes of
T4996 2837-2840 NN denotes deH
T4997 2841-2844 NN denotes deH
T4998 2840-2841 HYPH denotes /
T4999 2845-2852 NNS denotes animals
T5000 2856-2865 JJ denotes identical
T5001 2866-2868 IN denotes to
T5002 2869-2873 DT denotes that
T5003 2874-2883 VBN denotes described
T5004 2884-2887 IN denotes for
T5005 2888-2891 DT denotes the
T5006 2901-2907 NN denotes allele
T5007 2892-2900 JJ denotes original
T5008 2907-2908 . denotes .
T5009 2908-3015 sentence denotes In addition, other than M6pr-ps, no other genes or transcripts have been annotated to the 216 kb deletion.
T5010 2909-2911 IN denotes In
T5011 2982-2991 VBN denotes annotated
T5012 2912-2920 NN denotes addition
T5013 2920-2922 , denotes ,
T5014 2922-2927 JJ denotes other
T5015 2928-2932 IN denotes than
T5016 2933-2937 NN denotes M6pr
T5017 2938-2940 NN denotes ps
T5018 2937-2938 HYPH denotes -
T5019 2940-2942 , denotes ,
T5020 2942-2944 DT denotes no
T5021 2951-2956 NNS denotes genes
T5022 2945-2950 JJ denotes other
T5023 2957-2959 CC denotes or
T5024 2960-2971 NNS denotes transcripts
T5025 2972-2976 VBP denotes have
T5026 2977-2981 VBN denotes been
T5027 2992-2994 IN denotes to
T5028 2995-2998 DT denotes the
T5029 3006-3014 NN denotes deletion
T5030 2999-3002 CD denotes 216
T5031 3003-3005 NN denotes kb
T5032 3014-3015 . denotes .
T5033 3015-3169 sentence denotes While the positional cloning work was underway, one of us (A. Russ) generated an independent mutation of Tbx15 by gene targeting in embryonic stem cells.
T5034 3016-3021 IN denotes While
T5035 3050-3053 VBD denotes was
T5036 3022-3025 DT denotes the
T5037 3045-3049 NN denotes work
T5038 3026-3036 JJ denotes positional
T5039 3037-3044 NN denotes cloning
T5040 3084-3093 VBD denotes generated
T5041 3054-3062 RB denotes underway
T5042 3062-3064 , denotes ,
T5043 3064-3067 CD denotes one
T5044 3068-3070 IN denotes of
T5045 3071-3073 PRP denotes us
T5046 3074-3075 -LRB- denotes (
T5047 3075-3077 NNP denotes A.
T5048 3078-3082 NNP denotes Russ
T5049 3082-3083 -RRB- denotes )
T5050 3094-3096 DT denotes an
T5051 3109-3117 NN denotes mutation
T5052 3097-3108 JJ denotes independent
T5053 3118-3120 IN denotes of
T5054 3121-3126 NN denotes Tbx15
T5055 3127-3129 IN denotes by
T5056 3130-3134 NN denotes gene
T5057 3135-3144 NN denotes targeting
T5058 3145-3147 IN denotes in
T5059 3148-3157 JJ denotes embryonic
T5060 3163-3168 NNS denotes cells
T5061 3158-3162 NN denotes stem
T5062 3168-3169 . denotes .
T5063 3169-3329 sentence denotes The targeted allele, Tbx15LacZ, carries an IRES-LacZ-neo cDNA cassette that disrupts the open reading frame at codon 154 early in the T-box domain (Figure 3D).
T5064 3170-3173 DT denotes The
T5065 3183-3189 NN denotes allele
T5066 3174-3182 VBN denotes targeted
T5067 3202-3209 VBZ denotes carries
T5068 3189-3191 , denotes ,
T5069 3191-3200 NN denotes Tbx15LacZ
T5070 3200-3202 , denotes ,
T5071 3210-3212 DT denotes an
T5072 3232-3240 NN denotes cassette
T5073 3213-3217 NN denotes IRES
T5074 3218-3222 NN denotes LacZ
T5075 3217-3218 HYPH denotes -
T5076 3222-3223 HYPH denotes -
T5077 3223-3226 JJ denotes neo
T5078 3227-3231 NN denotes cDNA
T5079 3241-3245 WDT denotes that
T5080 3246-3254 VBZ denotes disrupts
T5081 3255-3258 DT denotes the
T5082 3272-3277 NN denotes frame
T5083 3259-3263 JJ denotes open
T5084 3264-3271 NN denotes reading
T5085 3278-3280 IN denotes at
T5086 3281-3286 NN denotes codon
T5087 3287-3290 CD denotes 154
T5088 3291-3296 RB denotes early
T5089 3297-3299 IN denotes in
T5090 3300-3303 DT denotes the
T5091 3310-3316 NN denotes domain
T5092 3304-3305 NN denotes T
T5093 3306-3309 NN denotes box
T5094 3305-3306 HYPH denotes -
T5095 3317-3318 -LRB- denotes (
T5096 3318-3324 NN denotes Figure
T5097 3325-3327 CD denotes 3D
T5098 3327-3328 -RRB- denotes )
T5099 3328-3329 . denotes .
T5100 3329-3616 sentence denotes Animals heterozygous for the targeted allele are completely normal with regard to size, skeletal morphology, and hair-color distribution, but Tbx15LacZ/Tbx15LacZ homozygotes were noted to exhibit reduced body size and an abnormal craniofacial appearance identical to that caused by deH.
T5101 3330-3337 NNS denotes Animals
T5102 3375-3378 VBP denotes are
T5103 3338-3350 JJ denotes heterozygous
T5104 3351-3354 IN denotes for
T5105 3355-3358 DT denotes the
T5106 3368-3374 NN denotes allele
T5107 3359-3367 VBN denotes targeted
T5108 3379-3389 RB denotes completely
T5109 3390-3396 JJ denotes normal
T5110 3397-3401 IN denotes with
T5111 3402-3408 NN denotes regard
T5112 3409-3411 IN denotes to
T5113 3412-3416 NN denotes size
T5114 3416-3418 , denotes ,
T5115 3418-3426 JJ denotes skeletal
T5116 3427-3437 NN denotes morphology
T5117 3437-3439 , denotes ,
T5118 3439-3442 CC denotes and
T5119 3443-3447 NN denotes hair
T5120 3448-3453 NN denotes color
T5121 3447-3448 HYPH denotes -
T5122 3454-3466 NN denotes distribution
T5123 3466-3468 , denotes ,
T5124 3468-3471 CC denotes but
T5125 3472-3481 NN denotes Tbx15LacZ
T5126 3482-3491 NN denotes Tbx15LacZ
T5127 3481-3482 HYPH denotes /
T5128 3492-3503 NNS denotes homozygotes
T5129 3509-3514 VBN denotes noted
T5130 3504-3508 VBD denotes were
T5131 3515-3517 TO denotes to
T5132 3518-3525 VB denotes exhibit
T5133 3526-3533 VBN denotes reduced
T5134 3539-3543 NN denotes size
T5135 3534-3538 NN denotes body
T5136 3544-3547 CC denotes and
T5137 3548-3550 DT denotes an
T5138 3573-3583 NN denotes appearance
T5139 3551-3559 JJ denotes abnormal
T5140 3560-3572 JJ denotes craniofacial
T5141 3584-3593 JJ denotes identical
T5142 3594-3596 IN denotes to
T5143 3597-3601 DT denotes that
T5144 3602-3608 VBN denotes caused
T5145 3609-3611 IN denotes by
T5146 3612-3615 NN denotes deH
T5147 3615-3616 . denotes .
T5148 3616-3862 sentence denotes We generated Tbx15LacZ/deH compound heterozygotes; on an Aw/at background, these animals exhibited the same abnormal restriction of dorsal pigmentation at P3.5 and expanded yellow flank area as described above for deH/deH animals (see Figure 2).
T5149 3617-3619 PRP denotes We
T5150 3620-3629 VBD denotes generated
T5151 3706-3715 VBD denotes exhibited
T5152 3630-3639 NN denotes Tbx15LacZ
T5153 3640-3643 NN denotes deH
T5154 3639-3640 SYM denotes /
T5155 3653-3666 NNS denotes heterozygotes
T5156 3644-3652 NN denotes compound
T5157 3666-3667 : denotes ;
T5158 3668-3670 IN denotes on
T5159 3671-3673 DT denotes an
T5160 3680-3690 NN denotes background
T5161 3674-3676 NN denotes Aw
T5162 3677-3679 NN denotes at
T5163 3676-3677 HYPH denotes /
T5164 3690-3692 , denotes ,
T5165 3692-3697 DT denotes these
T5166 3698-3705 NNS denotes animals
T5167 3716-3719 DT denotes the
T5168 3734-3745 NN denotes restriction
T5169 3720-3724 JJ denotes same
T5170 3725-3733 JJ denotes abnormal
T5171 3746-3748 IN denotes of
T5172 3749-3755 JJ denotes dorsal
T5173 3756-3768 NN denotes pigmentation
T5174 3769-3771 IN denotes at
T5175 3772-3776 NN denotes P3.5
T5176 3777-3780 CC denotes and
T5177 3781-3789 VBN denotes expanded
T5178 3803-3807 NN denotes area
T5179 3790-3796 JJ denotes yellow
T5180 3797-3802 NN denotes flank
T5181 3808-3810 IN denotes as
T5182 3811-3820 VBN denotes described
T5183 3821-3826 RB denotes above
T5184 3827-3830 IN denotes for
T5185 3831-3834 NN denotes deH
T5186 3835-3838 NN denotes deH
T5187 3834-3835 HYPH denotes /
T5188 3839-3846 NNS denotes animals
T5189 3847-3848 -LRB- denotes (
T5190 3848-3851 VB denotes see
T5191 3852-3858 NN denotes Figure
T5192 3859-3860 CD denotes 2
T5193 3860-3861 -RRB- denotes )
T5194 3861-3862 . denotes .
T5195 3862-3995 sentence denotes These observations demonstrate that the pigmentary and craniofacial characteristics of deH are caused by loss of function for Tbx15.
T5196 3863-3868 DT denotes These
T5197 3869-3881 NNS denotes observations
T5198 3882-3893 VBP denotes demonstrate
T5199 3894-3898 IN denotes that
T5200 3958-3964 VBN denotes caused
T5201 3899-3902 DT denotes the
T5202 3931-3946 NNS denotes characteristics
T5203 3903-3913 JJ denotes pigmentary
T5204 3914-3917 CC denotes and
T5205 3918-3930 JJ denotes craniofacial
T5206 3947-3949 IN denotes of
T5207 3950-3953 NN denotes deH
T5208 3954-3957 VBP denotes are
T5209 3965-3967 IN denotes by
T5210 3968-3972 NN denotes loss
T5211 3973-3975 IN denotes of
T5212 3976-3984 NN denotes function
T5213 3985-3988 IN denotes for
T5214 3989-3994 NN denotes Tbx15
T5215 3994-3995 . denotes .
R3088 T4613 T4614 amod Positional,Cloning
R3089 T4615 T4614 prep of,Cloning
R3090 T4616 T4615 pobj deH,of
R3091 T4618 T4619 prep As,identified
R3092 T4620 T4621 det a,marker
R3093 T4621 T4618 pobj marker,As
R3094 T4622 T4621 amod visible,marker
R3095 T4623 T4619 punct ", ",identified
R3096 T4624 T4625 amod early,studies
R3097 T4625 T4619 nsubj studies,identified
R3098 T4626 T4625 compound linkage,studies
R3099 T4627 T4625 prep with,studies
R3100 T4628 T4629 det the,allele
R3101 T4629 T4627 pobj allele,with
R3102 T4630 T4629 amod original,allele
R3103 T4631 T4632 amod droopy,ear
R3104 T4632 T4629 compound ear,allele
R3105 T4633 T4629 cc or,allele
R3106 T4634 T4635 det the,allele
R3107 T4635 T4629 conj allele,allele
R3108 T4636 T4635 compound deH,allele
R3109 T4637 T4638 det a,position
R3110 T4638 T4619 dobj position,identified
R3111 T4639 T4638 compound map,position
R3112 T4640 T4638 prep in,position
R3113 T4641 T4642 det the,middle
R3114 T4642 T4640 pobj middle,in
R3115 T4643 T4642 prep of,middle
R3116 T4644 T4643 pobj Chromosome,of
R3117 T4645 T4644 nummod 3,Chromosome
R3118 T4646 T4638 punct ", ",position
R3119 T4647 T4638 amod distal,position
R3120 T4648 T4647 prep to,distal
R3121 T4649 T4648 amod matted,to
R3122 T4650 T4647 cc and,distal
R3123 T4651 T4647 conj proximal,distal
R3124 T4652 T4651 prep to,proximal
R3125 T4653 T4654 compound Varitint,waddler
R3126 T4654 T4652 pobj waddler,to
R3127 T4655 T4654 punct -,waddler
R3128 T4656 T4657 punct (,Carter
R3129 T4657 T4619 meta Carter,identified
R3130 T4658 T4657 cc and,Carter
R3131 T4659 T4657 conj Falconer,Carter
R3132 T4660 T4659 nummod 1951,Falconer
R3133 T4661 T4659 punct ;,Falconer
R3134 T4662 T4659 conj Curry,Falconer
R3135 T4663 T4662 nummod 1959,Curry
R3136 T4664 T4662 punct ;,Curry
R3137 T4665 T4662 conj Lane,Curry
R3138 T4666 T4665 cc and,Lane
R3139 T4667 T4665 conj Eicher,Lane
R3140 T4668 T4667 nummod 1979,Eicher
R3141 T4669 T4667 punct ;,Eicher
R3142 T4670 T4667 conj Holmes,Eicher
R3143 T4671 T4670 nmod et,Holmes
R3144 T4672 T4670 nmod al.,Holmes
R3145 T4673 T4670 nummod 1981,Holmes
R3146 T4674 T4670 punct ),Holmes
R3147 T4675 T4619 punct .,identified
R3148 T4677 T4678 nsubj We,used
R3149 T4679 T4680 det an,intercross
R3150 T4680 T4678 dobj intercross,used
R3151 T4681 T4680 compound F2,intercross
R3152 T4682 T4680 prep with,intercross
R3153 T4683 T4684 compound CAST,Ei
R3154 T4684 T4686 compound Ei,mice
R3155 T4685 T4684 punct /,Ei
R3156 T4686 T4682 pobj mice,with
R3157 T4687 T4688 aux to,localize
R3158 T4688 T4678 advcl localize,used
R3159 T4689 T4688 dobj deH,localize
R3160 T4690 T4688 prep to,localize
R3161 T4691 T4692 det a,interval
R3162 T4692 T4690 pobj interval,to
R3163 T4693 T4694 nummod 0.1,cM
R3164 T4694 T4692 compound cM,interval
R3165 T4695 T4692 prep between,interval
R3166 T4696 T4695 pobj D3Mit213,between
R3167 T4697 T4696 cc and,D3Mit213
R3168 T4698 T4696 conj 16.MMHAP32FLF1,D3Mit213
R3169 T4699 T4692 punct ", ",interval
R3170 T4700 T4701 dep which,refined
R3171 T4701 T4692 relcl refined,interval
R3172 T4702 T4701 auxpass was,refined
R3173 T4703 T4701 prep by,refined
R3174 T4704 T4703 pobj development,by
R3175 T4705 T4704 prep of,development
R3176 T4706 T4707 det a,contig
R3177 T4707 T4705 pobj contig,of
R3178 T4708 T4709 amod bacterial,chromosome
R3179 T4709 T4707 nmod chromosome,contig
R3180 T4710 T4709 amod artificial,chromosome
R3181 T4711 T4709 punct (,chromosome
R3182 T4712 T4709 appos BAC,chromosome
R3183 T4713 T4707 punct ),contig
R3184 T4714 T4707 cc and,contig
R3185 T4715 T4716 amod additional,markers
R3186 T4716 T4707 conj markers,contig
R3187 T4717 T4716 prep to,markers
R3188 T4718 T4719 det a,region
R3189 T4719 T4717 pobj region,to
R3190 T4720 T4721 nummod 1.4,Mb
R3191 T4721 T4719 compound Mb,region
R3192 T4722 T4723 dep that,contained
R3193 T4723 T4719 relcl contained,region
R3194 T4724 T4725 nummod eight,genes
R3195 T4725 T4723 dobj genes,contained
R3196 T4726 T4725 punct ", ",genes
R3197 T4727 T4725 prep including,genes
R3198 T4728 T4727 pobj Tbx15,including
R3199 T4729 T4730 punct (,Figure
R3200 T4730 T4688 parataxis Figure,localize
R3201 T4731 T4730 nummod 3A,Figure
R3202 T4732 T4730 punct ),Figure
R3203 T4733 T4678 punct .,used
R3204 T4735 T4736 nsubj We,considered
R3205 T4737 T4736 dobj Tbx15,considered
R3206 T4738 T4736 prep as,considered
R3207 T4739 T4740 det an,candidate
R3208 T4740 T4738 pobj candidate,as
R3209 T4741 T4740 amod excellent,candidate
R3210 T4742 T4740 prep for,candidate
R3211 T4743 T4744 det the,abnormalities
R3212 T4744 T4742 pobj abnormalities,for
R3213 T4745 T4744 amod skeletal,abnormalities
R3214 T4746 T4744 acl caused,abnormalities
R3215 T4747 T4746 agent by,caused
R3216 T4748 T4747 pobj deH,by
R3217 T4749 T4736 punct ", ",considered
R3218 T4750 T4736 prep based,considered
R3219 T4751 T4750 prep on,based
R3220 T4752 T4751 pobj studies,on
R3221 T4753 T4752 prep by,studies
R3222 T4754 T4753 pobj Agulnik,by
R3223 T4755 T4756 advmod et,al.
R3224 T4756 T4754 advmod al.,Agulnik
R3225 T4757 T4754 punct (,Agulnik
R3226 T4758 T4754 npadvmod 1998,Agulnik
R3227 T4759 T4754 punct ),Agulnik
R3228 T4760 T4754 punct ", ",Agulnik
R3229 T4761 T4762 dep who,described
R3230 T4762 T4754 relcl described,Agulnik
R3231 T4763 T4764 poss its,expression
R3232 T4764 T4762 dobj expression,described
R3233 T4765 T4764 amod embryonic,expression
R3234 T4766 T4764 prep in,expression
R3235 T4767 T4768 det the,region
R3236 T4768 T4766 pobj region,in
R3237 T4769 T4768 amod craniofacial,region
R3238 T4770 T4768 cc and,region
R3239 T4771 T4772 amod developing,limbs
R3240 T4772 T4768 conj limbs,region
R3241 T4773 T4736 punct .,considered
R3242 T4775 T4776 advcl Using,found
R3243 T4777 T4778 compound sequence,information
R3244 T4778 T4775 dobj information,Using
R3245 T4779 T4778 prep from,information
R3246 T4780 T4779 pobj Agulnik,from
R3247 T4781 T4782 advmod et,al.
R3248 T4782 T4780 advmod al.,Agulnik
R3249 T4783 T4780 punct (,Agulnik
R3250 T4784 T4780 npadvmod 1998,Agulnik
R3251 T4785 T4780 punct ),Agulnik
R3252 T4786 T4778 cc and,information
R3253 T4787 T4788 det the,sequence
R3255 T4789 T4790 advmod partially,completed
R3256 T4790 T4788 amod completed,sequence
R3257 T4791 T4792 compound mouse,genome
R3258 T4792 T4788 compound genome,sequence
R3259 T4793 T4776 punct ", ",found
R3260 T4794 T4776 nsubj we,found
R3261 T4795 T4796 mark that,amplified
R3262 T4796 T4776 ccomp amplified,found
R3263 T4797 T4796 nsubjpass portions,amplified
R3264 T4798 T4797 prep of,portions
R3265 T4799 T4800 amod several,exons
R3266 T4800 T4798 pobj exons,of
R3267 T4801 T4800 compound Tbx15,exons
R3268 T4802 T4796 aux could,amplified
R3269 T4803 T4796 neg not,amplified
R3270 T4804 T4796 auxpass be,amplified
R3271 T4805 T4796 prep from,amplified
R3272 T4806 T4807 nmod deH,deH
R3273 T4807 T4809 nmod deH,DNA
R3274 T4808 T4807 punct /,deH
R3275 T4809 T4805 pobj DNA,from
R3276 T4810 T4809 amod genomic,DNA
R3277 T4811 T4776 punct .,found
R3278 T4813 T4814 det The,gene
R3279 T4814 T4816 nsubjpass gene,referred
R3280 T4815 T4814 amod same,gene
R3281 T4817 T4816 auxpass was,referred
R3282 T4818 T4816 advmod initially,referred
R3283 T4819 T4816 prep to,referred
R3284 T4820 T4816 prep as,referred
R3285 T4821 T4820 pobj Tbx8,as
R3286 T4822 T4823 punct (,Wattler
R3287 T4823 T4816 meta Wattler,referred
R3288 T4824 T4823 nmod et,Wattler
R3289 T4825 T4823 nmod al.,Wattler
R3290 T4826 T4823 nummod 1998,Wattler
R3291 T4827 T4823 punct ),Wattler
R3292 T4828 T4816 cc and,referred
R3293 T4829 T4830 advmod then,renamed
R3294 T4830 T4816 conj renamed,referred
R3295 T4831 T4830 advmod later,renamed
R3296 T4832 T4830 oprd Tbx14,renamed
R3297 T4833 T4830 punct ", ",renamed
R3298 T4834 T4830 cc but,renamed
R3299 T4835 T4836 auxpass is,referred
R3300 T4836 T4830 conj referred,renamed
R3301 T4837 T4836 advmod currently,referred
R3302 T4838 T4836 prep to,referred
R3303 T4839 T4836 prep in,referred
R3304 T4840 T4841 amod several,genomes
R3305 T4841 T4839 pobj genomes,in
R3306 T4842 T4841 compound vertebrate,genomes
R3307 T4843 T4836 prep as,referred
R3308 T4844 T4843 pobj Tbx15,as
R3309 T4845 T4846 punct (,Agulnik
R3310 T4846 T4836 meta Agulnik,referred
R3311 T4847 T4846 nmod et,Agulnik
R3312 T4848 T4846 nmod al.,Agulnik
R3313 T4849 T4846 nummod 1998,Agulnik
R3314 T4850 T4846 punct ;,Agulnik
R3315 T4851 T4846 nmod Begemann,Agulnik
R3316 T4852 T4846 nmod et,Agulnik
R3317 T4853 T4846 nmod al.,Agulnik
R3318 T4854 T4846 nummod 2002,Agulnik
R3319 T4855 T4846 punct ),Agulnik
R3320 T4856 T4816 punct .,referred
R3321 T4858 T4859 prep By,identified
R3322 T4860 T4858 pcomp comparing,By
R3323 T4861 T4862 det the,sequence
R3324 T4862 T4860 dobj sequence,comparing
R3325 T4863 T4862 prep of,sequence
R3326 T4864 T4865 det a,fragment
R3327 T4865 T4863 pobj fragment,of
R3328 T4866 T4867 nummod 1.3,kb
R3329 T4867 T4868 compound kb,junction
R3330 T4868 T4865 compound junction,fragment
R3331 T4869 T4865 acl amplified,fragment
R3332 T4870 T4869 prep from,amplified
R3333 T4871 T4872 nmod deH,deH
R3334 T4872 T4874 nmod deH,DNA
R3335 T4873 T4872 punct /,deH
R3336 T4874 T4870 pobj DNA,from
R3337 T4875 T4874 amod genomic,DNA
R3338 T4876 T4860 prep to,comparing
R3339 T4877 T4878 advmod publicly,available
R3340 T4878 T4879 amod available,sequence
R3341 T4879 T4876 pobj sequence,to
R3342 T4880 T4881 compound mouse,genome
R3343 T4881 T4879 compound genome,sequence
R3344 T4882 T4859 punct ", ",identified
R3345 T4883 T4859 nsubj we,identified
R3346 T4884 T4885 det a,deletion
R3347 T4885 T4859 dobj deletion,identified
R3348 T4886 T4887 nummod 216,kb
R3349 T4887 T4885 compound kb,deletion
R3350 T4888 T4889 dep that,extends
R3351 T4889 T4885 relcl extends,deletion
R3352 T4890 T4889 prep from,extends
R3353 T4891 T4892 compound Tbx15,intron
R3354 T4892 T4890 pobj intron,from
R3355 T4893 T4892 nummod 1,intron
R3356 T4894 T4889 prep to,extends
R3357 T4895 T4896 nummod 148,kb
R3358 T4896 T4897 npadvmod kb,downstream
R3359 T4897 T4894 pcomp downstream,to
R3360 T4898 T4897 prep of,downstream
R3361 T4899 T4900 det the,sequence
R3362 T4900 T4898 pobj sequence,of
R3363 T4901 T4900 compound polyadenylation,sequence
R3364 T4902 T4900 prep in,sequence
R3365 T4903 T4904 det a,region
R3366 T4904 T4902 pobj region,in
R3367 T4905 T4904 acl annotated,region
R3368 T4906 T4905 prep as,annotated
R3369 T4907 T4908 det a,pseudogene
R3370 T4908 T4906 pobj pseudogene,as
R3371 T4909 T4910 nmod mannose,phosphate
R3372 T4910 T4914 compound phosphate,receptor
R3373 T4911 T4910 punct -,phosphate
R3374 T4912 T4910 nummod 6,phosphate
R3375 T4913 T4910 punct -,phosphate
R3376 T4914 T4908 compound receptor,pseudogene
R3377 T4915 T4908 punct ", ",pseudogene
R3378 T4916 T4917 compound M6pr,ps
R3379 T4917 T4908 appos ps,pseudogene
R3380 T4918 T4917 punct -,ps
R3381 T4919 T4920 punct (,3B
R3382 T4920 T4859 parataxis 3B,identified
R3383 T4921 T4920 nmod Figure,3B
R3384 T4922 T4920 cc and,3B
R3385 T4923 T4920 conj 3C,3B
R3386 T4924 T4920 punct ),3B
R3387 T4925 T4859 punct .,identified
R3388 T4927 T4928 punct (,Ludwig
R3389 T4929 T4928 nmod et,Ludwig
R3390 T4930 T4928 nmod al.,Ludwig
R3391 T4931 T4928 nummod 1992,Ludwig
R3392 T4932 T4928 punct ),Ludwig
R3393 T4933 T4928 punct .,Ludwig
R3394 T4935 T4936 prep By,identified
R3395 T4937 T4938 compound Northern,blot
R3396 T4938 T4939 compound blot,analysis
R3397 T4939 T4935 pobj analysis,By
R3398 T4940 T4936 punct ", ",identified
R3399 T4941 T4936 nsubj we,identified
R3400 T4942 T4943 det a,transcript
R3401 T4943 T4936 dobj transcript,identified
R3402 T4944 T4943 compound fusion,transcript
R3403 T4945 T4943 acl produced,transcript
R3404 T4946 T4945 prep from,produced
R3405 T4947 T4948 det the,chromosome
R3406 T4948 T4946 pobj chromosome,from
R3407 T4949 T4948 compound deH,chromosome
R3408 T4950 T4951 punct (,shown
R3409 T4951 T4936 parataxis shown,identified
R3410 T4952 T4951 nsubj data,shown
R3411 T4953 T4951 neg not,shown
R3412 T4954 T4951 punct ),shown
R3413 T4955 T4936 punct .,identified
R3414 T4957 T4958 advmod However,removes
R3415 T4959 T4958 punct ", ",removes
R3416 T4960 T4961 det the,deletion
R3417 T4961 T4958 nsubj deletion,removes
R3418 T4962 T4963 quantmod 534,602
R3419 T4963 T4966 nummod 602,acids
R3420 T4964 T4963 quantmod of,602
R3421 T4965 T4963 quantmod the,602
R3422 T4966 T4958 dobj acids,removes
R3423 T4967 T4966 compound amino,acids
R3424 T4968 T4966 acl encoded,acids
R3425 T4969 T4968 agent by,encoded
R3426 T4970 T4969 pobj Tbx15,by
R3427 T4971 T4966 punct (,acids
R3428 T4972 T4966 prep including,acids
R3429 T4973 T4974 det the,domain
R3430 T4974 T4972 pobj domain,including
R3431 T4975 T4976 nmod T,box
R3432 T4976 T4974 nmod box,domain
R3433 T4977 T4976 punct -,box
R3434 T4978 T4979 npadvmod DNA,binding
R3435 T4979 T4974 amod binding,domain
R3436 T4980 T4979 punct -,binding
R3437 T4981 T4958 punct ),removes
R3438 T4982 T4958 punct ", ",removes
R3439 T4983 T4984 nmod deH,animals
R3440 T4984 T4987 nsubj animals,are
R3441 T4985 T4983 punct /,deH
R3442 T4986 T4983 punct +,deH
R3443 T4987 T4958 conj are,removes
R3444 T4988 T4989 advmod grossly,normal
R3445 T4989 T4987 acomp normal,are
R3446 T4990 T4987 punct ", ",are
R3447 T4991 T4987 cc and,are
R3448 T4992 T4993 det the,phenotype
R3449 T4993 T4994 nsubj phenotype,is
R3450 T4994 T4987 conj is,are
R3451 T4995 T4993 prep of,phenotype
R3452 T4996 T4997 compound deH,deH
R3453 T4997 T4999 compound deH,animals
R3454 T4998 T4997 punct /,deH
R3455 T4999 T4995 pobj animals,of
R3456 T5000 T4994 acomp identical,is
R3457 T5001 T5000 prep to,identical
R3458 T5002 T5001 pobj that,to
R3459 T5003 T5002 acl described,that
R3460 T5004 T5003 prep for,described
R3461 T5005 T5006 det the,allele
R3462 T5006 T5004 pobj allele,for
R3463 T5007 T5006 amod original,allele
R3464 T5008 T4994 punct .,is
R3465 T5010 T5011 prep In,annotated
R3466 T5012 T5010 pobj addition,In
R3467 T5013 T5011 punct ", ",annotated
R3468 T5014 T5011 amod other,annotated
R3469 T5015 T5014 prep than,other
R3470 T5016 T5017 compound M6pr,ps
R3471 T5017 T5015 pobj ps,than
R3472 T5018 T5017 punct -,ps
R3473 T5019 T5011 punct ", ",annotated
R3474 T5020 T5021 det no,genes
R3475 T5021 T5011 nsubjpass genes,annotated
R3476 T5022 T5021 amod other,genes
R3477 T5023 T5021 cc or,genes
R3478 T5024 T5021 conj transcripts,genes
R3479 T5025 T5011 aux have,annotated
R3480 T5026 T5011 auxpass been,annotated
R3481 T5027 T5011 prep to,annotated
R3482 T5028 T5029 det the,deletion
R3483 T5029 T5027 pobj deletion,to
R3484 T5030 T5031 nummod 216,kb
R3485 T5031 T5029 compound kb,deletion
R3486 T5032 T5011 punct .,annotated
R3487 T5034 T5035 mark While,was
R3489 T5036 T5037 det the,work
R3490 T5037 T5035 nsubj work,was
R3491 T5038 T5037 amod positional,work
R3492 T5039 T5037 compound cloning,work
R3493 T5041 T5035 advmod underway,was
R3494 T5042 T5040 punct ", ",generated
R3495 T5043 T5040 nsubj one,generated
R3496 T5044 T5043 prep of,one
R3497 T5045 T5044 pobj us,of
R3498 T5046 T5043 punct (,one
R3499 T5047 T5048 compound A.,Russ
R3500 T5048 T5043 appos Russ,one
R3501 T5049 T5043 punct ),one
R3502 T5050 T5051 det an,mutation
R3503 T5051 T5040 dobj mutation,generated
R3504 T5052 T5051 amod independent,mutation
R3505 T5053 T5051 prep of,mutation
R3506 T5054 T5053 pobj Tbx15,of
R3507 T5055 T5040 prep by,generated
R3508 T5056 T5057 compound gene,targeting
R3509 T5057 T5055 pobj targeting,by
R3510 T5058 T5057 prep in,targeting
R3511 T5059 T5060 amod embryonic,cells
R3512 T5060 T5058 pobj cells,in
R3513 T5061 T5060 compound stem,cells
R3514 T5062 T5040 punct .,generated
R3515 T5064 T5065 det The,allele
R3516 T5065 T5067 nsubj allele,carries
R3517 T5066 T5065 amod targeted,allele
R3518 T5068 T5065 punct ", ",allele
R3519 T5069 T5065 appos Tbx15LacZ,allele
R3520 T5070 T5067 punct ", ",carries
R3521 T5071 T5072 det an,cassette
R3522 T5072 T5067 dobj cassette,carries
R3523 T5073 T5074 nmod IRES,LacZ
R3524 T5074 T5072 nmod LacZ,cassette
R3525 T5075 T5074 punct -,LacZ
R3526 T5076 T5074 punct -,LacZ
R3527 T5077 T5074 amod neo,LacZ
R3528 T5078 T5072 compound cDNA,cassette
R3529 T5079 T5080 dep that,disrupts
R3530 T5080 T5072 relcl disrupts,cassette
R3531 T5081 T5082 det the,frame
R3532 T5082 T5080 dobj frame,disrupts
R3533 T5083 T5082 amod open,frame
R3534 T5084 T5082 compound reading,frame
R3535 T5085 T5082 prep at,frame
R3536 T5086 T5085 pobj codon,at
R3537 T5087 T5086 nummod 154,codon
R3538 T5088 T5080 advmod early,disrupts
R3539 T5089 T5080 prep in,disrupts
R3540 T5090 T5091 det the,domain
R3541 T5091 T5089 pobj domain,in
R3542 T5092 T5093 compound T,box
R3543 T5093 T5091 compound box,domain
R3544 T5094 T5093 punct -,box
R3545 T5095 T5096 punct (,Figure
R3546 T5096 T5080 parataxis Figure,disrupts
R3547 T5097 T5096 nummod 3D,Figure
R3548 T5098 T5096 punct ),Figure
R3549 T5099 T5067 punct .,carries
R3550 T5101 T5102 nsubj Animals,are
R3551 T5103 T5101 amod heterozygous,Animals
R3552 T5104 T5103 prep for,heterozygous
R3553 T5105 T5106 det the,allele
R3554 T5106 T5104 pobj allele,for
R3555 T5107 T5106 amod targeted,allele
R3556 T5108 T5109 advmod completely,normal
R3557 T5109 T5102 acomp normal,are
R3558 T5110 T5102 prep with,are
R3559 T5111 T5110 pobj regard,with
R3560 T5112 T5111 prep to,regard
R3561 T5113 T5112 pobj size,to
R3562 T5114 T5113 punct ", ",size
R3563 T5115 T5116 amod skeletal,morphology
R3564 T5116 T5113 conj morphology,size
R3565 T5117 T5116 punct ", ",morphology
R3566 T5118 T5116 cc and,morphology
R3567 T5119 T5120 compound hair,color
R3568 T5120 T5122 compound color,distribution
R3569 T5121 T5120 punct -,color
R3570 T5122 T5116 conj distribution,morphology
R3571 T5123 T5102 punct ", ",are
R3572 T5124 T5102 cc but,are
R3573 T5125 T5126 compound Tbx15LacZ,Tbx15LacZ
R3574 T5126 T5128 compound Tbx15LacZ,homozygotes
R3575 T5127 T5126 punct /,Tbx15LacZ
R3576 T5128 T5129 nsubjpass homozygotes,noted
R3577 T5129 T5102 conj noted,are
R3578 T5130 T5129 auxpass were,noted
R3579 T5131 T5132 aux to,exhibit
R3580 T5132 T5129 xcomp exhibit,noted
R3581 T5133 T5134 amod reduced,size
R3582 T5134 T5132 dobj size,exhibit
R3583 T5135 T5134 compound body,size
R3584 T5136 T5134 cc and,size
R3585 T5137 T5138 det an,appearance
R3586 T5138 T5134 conj appearance,size
R3587 T5139 T5138 amod abnormal,appearance
R3588 T5140 T5138 amod craniofacial,appearance
R3589 T5141 T5138 amod identical,appearance
R3590 T5142 T5141 prep to,identical
R3591 T5143 T5142 pobj that,to
R3592 T5144 T5143 acl caused,that
R3593 T5145 T5144 agent by,caused
R3594 T5146 T5145 pobj deH,by
R3595 T5147 T5129 punct .,noted
R3596 T5149 T5150 nsubj We,generated
R3597 T5150 T5151 ccomp generated,exhibited
R3598 T5152 T5153 nmod Tbx15LacZ,deH
R3599 T5153 T5155 compound deH,heterozygotes
R3600 T5154 T5153 punct /,deH
R3601 T5155 T5150 dobj heterozygotes,generated
R3602 T5156 T5155 compound compound,heterozygotes
R3603 T5157 T5151 punct ;,exhibited
R3604 T5158 T5151 prep on,exhibited
R3605 T5159 T5160 det an,background
R3606 T5160 T5158 pobj background,on
R3607 T5161 T5162 compound Aw,at
R3608 T5162 T5160 compound at,background
R3609 T5163 T5162 punct /,at
R3610 T5164 T5151 punct ", ",exhibited
R3611 T5165 T5166 det these,animals
R3612 T5166 T5151 nsubj animals,exhibited
R3613 T5167 T5168 det the,restriction
R3614 T5168 T5151 dobj restriction,exhibited
R3615 T5169 T5168 amod same,restriction
R3616 T5170 T5168 amod abnormal,restriction
R3617 T5171 T5168 prep of,restriction
R3618 T5172 T5173 amod dorsal,pigmentation
R3619 T5173 T5171 pobj pigmentation,of
R3620 T5174 T5168 prep at,restriction
R3621 T5175 T5174 pobj P3.5,at
R3622 T5176 T5168 cc and,restriction
R3623 T5177 T5178 amod expanded,area
R3624 T5178 T5168 conj area,restriction
R3625 T5179 T5178 amod yellow,area
R3626 T5180 T5178 compound flank,area
R3627 T5181 T5182 mark as,described
R3628 T5182 T5151 advcl described,exhibited
R3629 T5183 T5182 advmod above,described
R3630 T5184 T5182 prep for,described
R3631 T5185 T5186 compound deH,deH
R3632 T5186 T5188 compound deH,animals
R3633 T5187 T5186 punct /,deH
R3634 T5188 T5184 pobj animals,for
R3635 T5189 T5190 punct (,see
R3636 T5190 T5151 parataxis see,exhibited
R3637 T5191 T5190 dobj Figure,see
R3638 T5192 T5191 nummod 2,Figure
R3639 T5193 T5190 punct ),see
R3640 T5194 T5151 punct .,exhibited
R3641 T5196 T5197 det These,observations
R3642 T5197 T5198 nsubj observations,demonstrate
R3643 T5199 T5200 mark that,caused
R3644 T5200 T5198 ccomp caused,demonstrate
R3645 T5201 T5202 det the,characteristics
R3646 T5202 T5200 nsubjpass characteristics,caused
R3647 T5203 T5202 amod pigmentary,characteristics
R3648 T5204 T5203 cc and,pigmentary
R3649 T5205 T5203 conj craniofacial,pigmentary
R3650 T5206 T5202 prep of,characteristics
R3651 T5207 T5206 pobj deH,of
R3652 T5208 T5200 auxpass are,caused
R3653 T5209 T5200 agent by,caused
R3654 T5210 T5209 pobj loss,by
R3655 T5211 T5210 prep of,loss
R3656 T5212 T5211 pobj function,of
R3657 T5213 T5210 prep for,loss
R3658 T5214 T5213 pobj Tbx15,for
R3659 T5215 T5198 punct .,demonstrate
R3254 T4788 T4778 conj sequence,information
R3488 T5035 T5040 advcl was,generated

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T4427 94-97 UBERON:0001690 denotes ear
T4428 98-104 SO:0001023 denotes allele
T4429 116-122 SO:0001023 denotes allele
T4430 350-354 NCBITaxon:10088 denotes mice
T4431 467-476 NCBITaxon:2 denotes bacterial
T4432 467-498 SO:0000153 denotes bacterial artificial chromosome
T4433 500-503 SO:0000153 denotes BAC
T4434 505-511 SO:0000149 denotes contig
T4435 575-580 SO:0000704 denotes genes
T4436 592-597 PR:000016145 denotes Tbx15
T4437 625-630 PR:000016145 denotes Tbx15
T4438 665-673 UBERON:0004288 denotes skeletal
T4439 764-773 UBERON:0000922 denotes embryonic
T4440 774-784 GO:0010467 denotes expression
T4441 827-832 UBERON:0002101 denotes limbs
T4442 1851-1856 NCBITaxon:10088 denotes mouse
T4443 1857-1863 SO:0001026 denotes genome
T4444 1888-1899 _FRAGMENT denotes portions of
T4445 1914-1919 SO:0000852 denotes exons
T4446 1908-1913 PR:000016145 denotes Tbx15
T4447 1956-1963 SO:0001026 denotes genomic
T4448 1978-1982 SO:0000704 denotes gene
T4449 2012-2016 PR:000016145 denotes Tbx8
T4450 2062-2067 PR:000016145 denotes Tbx14
T4451 2109-2119 NCBITaxon:7742 denotes vertebrate
T4452 2120-2127 SO:0001026 denotes genomes
T4453 2131-2136 PR:000016145 denotes Tbx15
T4454 2261-2268 SO:0001026 denotes genomic
T4455 2295-2300 NCBITaxon:10088 denotes mouse
T4456 2301-2307 SO:0001026 denotes genome
T4457 2368-2373 PR:000016145 denotes Tbx15
T4458 2374-2380 SO:0000188 denotes intron
T4459 2411-2426 GO:0043631 denotes polyadenylation
T4460 2411-2435 SO:0000610 denotes polyadenylation sequence
T4461 2463-2482 CHEBI:17369 denotes mannose-6-phosphate
T4462 2492-2502 SO:0000336 denotes pseudogene
T4463 2509-2511 SO:0000336 denotes ps
T4464 2604-2614 SO:0000673 denotes transcript
T4465 2734-2739 PR:000016145 denotes Tbx15
T4466 2773-2779 SO:0000417 denotes domain
T4467 2788-2795 NCBITaxon:33208 denotes animals
T4468 2845-2852 NCBITaxon:33208 denotes animals
T4469 2901-2907 SO:0001023 denotes allele
T4470 2938-2940 SO:0000336 denotes ps
T4471 2951-2956 SO:0000704 denotes genes
T4472 2960-2971 SO:0000673 denotes transcripts
T4473 3121-3126 PR:000016145 denotes Tbx15
T4474 3130-3134 SO:0000704 denotes gene
T4475 3148-3157 UBERON:0000922 denotes embryonic
T4476 3148-3168 CL:0002322 denotes embryonic stem cells
T4477 3183-3189 SO:0001023 denotes allele
T4478 3191-3196 PR:000016145 denotes Tbx15
T4479 3196-3200 PR:000033987 denotes LacZ
T4480 3213-3217 SO:0000243 denotes IRES
T4481 3218-3222 PR:000033987 denotes LacZ
T4482 3232-3240 SO:0005853 denotes cassette
T4483 3259-3277 SO:0000236 denotes open reading frame
T4484 3281-3286 SO:0000360 denotes codon
T4485 3310-3316 SO:0000417 denotes domain
T4486 3330-3337 NCBITaxon:33208 denotes Animals
T4487 3368-3374 SO:0001023 denotes allele
T4488 3418-3426 UBERON:0004288 denotes skeletal
T4489 3443-3447 UBERON:0001037 denotes hair
T4490 3472-3477 PR:000016145 denotes Tbx15
T4491 3477-3481 PR:000033987 denotes LacZ
T4492 3482-3487 PR:000016145 denotes Tbx15
T4493 3487-3491 PR:000033987 denotes LacZ
T4494 3630-3635 PR:000016145 denotes Tbx15
T4495 3635-3639 PR:000033987 denotes LacZ
T4496 3698-3705 NCBITaxon:33208 denotes animals
T4497 3797-3802 UBERON:0000180 denotes flank
T4498 3839-3846 NCBITaxon:33208 denotes animals
T4499 3903-3913 CHEBI:26130 denotes pigmentary
T4500 3989-3994 PR:000016145 denotes Tbx15
R3086 T4445 T4444 _lexicallyChainedTo exons,portions of

2_test

Id Subject Object Predicate Lexical cue
14737183-24539711-84902992 251-255 24539711 denotes 1951
14737183-13654621-84902993 263-267 13654621 denotes 1959
14737183-489953-84902994 285-289 489953 denotes 1979
14737183-9693034-84902995 739-743 9693034 denotes 1998
14737183-9693034-84902996 1817-1821 9693034 denotes 1998
14737183-9503012-84902997 2033-2037 9503012 denotes 1998
14737183-9693034-84902998 2153-2157 9693034 denotes 1998
14737183-12175500-84902999 2175-2179 12175500 denotes 2002
14737183-1376319-84903000 2547-2551 1376319 denotes 1992
T49936 251-255 24539711 denotes 1951
T45512 263-267 13654621 denotes 1959
T81011 285-289 489953 denotes 1979
T15709 739-743 9693034 denotes 1998
T43472 1817-1821 9693034 denotes 1998
T40911 2033-2037 9503012 denotes 1998
T49725 2153-2157 9693034 denotes 1998
T90945 2175-2179 12175500 denotes 2002
T8080 2547-2551 1376319 denotes 1992

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T4501 11-18 SO_EXT:sequence_cloning_process denotes Cloning
T4502 39-45 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T4503 94-97 UBERON:0001690 denotes ear
T4504 98-104 SO_EXT:0001023 denotes allele
T4505 116-122 SO_EXT:0001023 denotes allele
T4506 166-176 GO_SO_EXT:chromosome denotes Chromosome
T4507 350-354 NCBITaxon:10088 denotes mice
T4508 467-476 NCBITaxon:2 denotes bacterial
T4509 467-498 SO_EXT:0000153 denotes bacterial artificial chromosome
T4510 488-498 GO_SO_EXT:chromosome denotes chromosome
T4511 500-503 SO_EXT:0000153 denotes BAC
T4512 505-511 SO_EXT:0000149 denotes contig
T4513 527-534 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T4514 545-546 CHEBI_SO_EXT:base denotes b
T4515 575-580 SO_EXT:0000704 denotes genes
T4516 592-597 PR_EXT:000016145 denotes Tbx15
T4517 625-630 PR_EXT:000016145 denotes Tbx15
T4518 665-673 UBERON:0004288 denotes skeletal
T4519 764-773 UBERON:0000922 denotes embryonic
T4520 774-784 GO:0010467 denotes expression
T4521 792-804 UBERON_EXT:face_or_skull denotes craniofacial
T4522 827-832 UBERON:0002101 denotes limbs
T4523 1775-1783 SO_EXT:biological_sequence denotes sequence
T4524 1851-1856 NCBITaxon:10088 denotes mouse
T4525 1857-1863 SO_EXT:0001026 denotes genome
T4526 1864-1872 SO_EXT:biological_sequence denotes sequence
T4527 1888-1899 _FRAGMENT denotes portions of
T4528 1914-1919 SO_EXT:0000852 denotes exons
T4529 1908-1913 PR_EXT:000016145 denotes Tbx15
T4530 1956-1967 SO_EXT:genomic_DNA denotes genomic DNA
T4531 1964-1967 CHEBI_SO_EXT:DNA denotes DNA
T4532 1978-1982 SO_EXT:0000704 denotes gene
T4533 2012-2016 PR_EXT:000016145 denotes Tbx8
T4534 2062-2067 PR_EXT:000016145 denotes Tbx14
T4535 2109-2119 NCBITaxon:7742 denotes vertebrate
T4536 2120-2127 SO_EXT:0001026 denotes genomes
T4537 2131-2136 PR_EXT:000016145 denotes Tbx15
T4538 2199-2207 SO_EXT:biological_sequence denotes sequence
T4539 2218-2219 CHEBI_SO_EXT:base denotes b
T4540 2261-2272 SO_EXT:genomic_DNA denotes genomic DNA
T4541 2269-2272 CHEBI_SO_EXT:DNA denotes DNA
T4542 2295-2300 NCBITaxon:10088 denotes mouse
T4543 2301-2307 SO_EXT:0001026 denotes genome
T4544 2308-2316 SO_EXT:biological_sequence denotes sequence
T4545 2339-2340 CHEBI_SO_EXT:base denotes b
T4546 2341-2349 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T4547 2368-2373 PR_EXT:000016145 denotes Tbx15
T4548 2374-2380 SO_EXT:0000188 denotes intron
T4549 2391-2392 CHEBI_SO_EXT:base denotes b
T4550 2393-2403 SO_EXT:sequence_downstreamness denotes downstream
T4551 2411-2426 GO:0043631 denotes polyadenylation
T4552 2411-2435 SO_EXT:0000610 denotes polyadenylation sequence
T4553 2463-2482 CHEBI:17369 denotes mannose-6-phosphate
T4554 2483-2491 GO_EXT:0004872 denotes receptor
T4555 2492-2502 SO_EXT:0000336 denotes pseudogene
T4556 2509-2511 SO_EXT:0000336 denotes ps
T4557 2597-2603 SO_EXT:sequence_fusion_entity_or_process denotes fusion
T4558 2604-2614 SO_EXT:0000673 denotes transcript
T4559 2637-2647 GO_SO_EXT:chromosome denotes chromosome
T4560 2679-2687 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T4561 2711-2722 CHEBI_SO_EXT:amino_acid denotes amino acids
T4562 2723-2730 SO_EXT:sequence_coding_function denotes encoded
T4563 2734-2739 PR_EXT:000016145 denotes Tbx15
T4564 2761-2764 CHEBI_SO_EXT:DNA denotes DNA
T4565 2765-2772 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T4566 2773-2779 SO_EXT:0000417 denotes domain
T4567 2786-2787 SO_EXT:normal_or_wild_type_or_present denotes +
T4568 2788-2795 NCBITaxon:33208 denotes animals
T4569 2845-2852 NCBITaxon:33208 denotes animals
T4570 2901-2907 SO_EXT:0001023 denotes allele
T4571 2938-2940 SO_EXT:0000336 denotes ps
T4572 2951-2956 SO_EXT:0000704 denotes genes
T4573 2960-2971 SO_EXT:0000673 denotes transcripts
T4574 3004-3005 CHEBI_SO_EXT:base denotes b
T4575 3006-3014 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T4576 3037-3044 SO_EXT:sequence_cloning_process denotes cloning
T4577 3109-3117 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T4578 3121-3126 PR_EXT:000016145 denotes Tbx15
T4579 3130-3134 SO_EXT:0000704 denotes gene
T4580 3148-3157 UBERON:0000922 denotes embryonic
T4581 3148-3168 CL:0002322 denotes embryonic stem cells
T4582 3163-3168 CL_GO_EXT:cell denotes cells
T4583 3183-3189 SO_EXT:0001023 denotes allele
T4584 3191-3196 PR_EXT:000016145 denotes Tbx15
T4585 3196-3200 PR_EXT:000033987 denotes LacZ
T4586 3213-3217 SO_EXT:0000243 denotes IRES
T4587 3218-3222 PR_EXT:000033987 denotes LacZ
T4588 3223-3226 CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase denotes neo
T4589 3227-3231 SO_EXT:cDNA denotes cDNA
T4590 3232-3240 SO_EXT:0005853 denotes cassette
T4591 3259-3277 SO_EXT:0000236 denotes open reading frame
T4592 3281-3286 SO_EXT:0000360 denotes codon
T4593 3310-3316 SO_EXT:0000417 denotes domain
T4594 3330-3337 NCBITaxon:33208 denotes Animals
T4595 3368-3374 SO_EXT:0001023 denotes allele
T4596 3418-3426 UBERON:0004288 denotes skeletal
T4597 3443-3447 UBERON:0001037 denotes hair
T4598 3472-3477 PR_EXT:000016145 denotes Tbx15
T4599 3477-3481 PR_EXT:000033987 denotes LacZ
T4600 3482-3487 PR_EXT:000016145 denotes Tbx15
T4601 3487-3491 PR_EXT:000033987 denotes LacZ
T4602 3534-3538 UBERON_EXT:body denotes body
T4603 3560-3572 UBERON_EXT:face_or_skull denotes craniofacial
T4604 3630-3635 PR_EXT:000016145 denotes Tbx15
T4605 3635-3639 PR_EXT:000033987 denotes LacZ
T4606 3698-3705 NCBITaxon:33208 denotes animals
T4607 3756-3768 GO_PATO_EXT:biological_pigmentation_process_or_quality denotes pigmentation
T4608 3797-3802 UBERON:0000180 denotes flank
T4609 3839-3846 NCBITaxon:33208 denotes animals
T4610 3903-3913 CHEBI_EXT:26130 denotes pigmentary
T4611 3918-3930 UBERON_EXT:face_or_skull denotes craniofacial
T4612 3989-3994 PR_EXT:000016145 denotes Tbx15
R3087 T4528 T4527 _lexicallyChainedTo exons,portions of