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measurements of hair length plotted as a function of dorsoventral position reveal that the apparent sharp boundary between dorsal and ventral pigment compartments in at/at mice coincides with a more gradual change in both hair color and hair length (Figure 1A–1D). Within the region of transition from dorsum to ventrum (Figure 1B), flank hairs from at/at mice become progressively shorter and exhibit increasing amounts of pheomelanin deposition progressing from the tip to the base of the hair. However, the region of transition for hair length is considerably broader than that for pigmentation and independent of Agouti genotype. Although hair-cycle timing varies along the rostrocaudal axis, measurements of absolute hair length for mice matched for age and rostrocaudal level are remarkably similar (Figure 1D). Furthermore, measurements of relative hair length for animals of different age, size, and Agouti genotype also are very similar when normalized to body circumference (Figure 1C). Taken together, these observations indicate that variation of hair length along the dorsoventral axis is stereotyped and maintained through multiple hair cycles, with a transition in hair length that is gradual and encompasses the pigment-type transition in at/at mice."}

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{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T2448","span":{"begin":33,"end":37},"obj":"UBERON:0001037"},{"id":"T2449","span":{"begin":159,"end":166},"obj":"CHEBI_EXT:26130"},{"id":"T2450","span":{"begin":189,"end":193},"obj":"NCBITaxon:10088"},{"id":"T2451","span":{"begin":239,"end":243},"obj":"UBERON:0001037"},{"id":"T2452","span":{"begin":254,"end":258},"obj":"UBERON:0001037"},{"id":"T2453","span":{"begin":319,"end":325},"obj":"UBERON:0001137"},{"id":"T2454","span":{"begin":329,"end":336},"obj":"UBERON:0013235"},{"id":"T2455","span":{"begin":350,"end":355},"obj":"UBERON:0000180"},{"id":"T2456","span":{"begin":356,"end":361},"obj":"UBERON:0001037"},{"id":"T2457","span":{"begin":373,"end":377},"obj":"NCBITaxon:10088"},{"id":"T2458","span":{"begin":441,"end":452},"obj":"CHEBI:81393"},{"id":"T2459","span":{"begin":508,"end":512},"obj":"UBERON:0001037"},{"id":"T2460","span":{"begin":552,"end":556},"obj":"UBERON:0001037"},{"id":"T2461","span":{"begin":602,"end":614},"obj":"GO_PATO_EXT:biological_pigmentation_process_or_quality"},{"id":"T2462","span":{"begin":634,"end":640},"obj":"PR_EXT:000004372"},{"id":"T2463","span":{"begin":641,"end":649},"obj":"SO_EXT:genotype_or_entity_with_genotype"},{"id":"T2464","span":{"begin":660,"end":664},"obj":"UBERON:0001037"},{"id":"T2465","span":{"begin":660,"end":670},"obj":"GO:0042633"},{"id":"T2466","span":{"begin":739,"end":743},"obj":"UBERON:0001037"},{"id":"T2467","span":{"begin":755,"end":759},"obj":"NCBITaxon:10088"},{"id":"T2468","span":{"begin":873,"end":877},"obj":"UBERON:0001037"},{"id":"T2469","span":{"begin":889,"end":896},"obj":"NCBITaxon:33208"},{"id":"T2470","span":{"begin":925,"end":931},"obj":"PR_EXT:000004372"},{"id":"T2471","span":{"begin":932,"end":940},"obj":"SO_EXT:genotype_or_entity_with_genotype"},{"id":"T2472","span":{"begin":982,"end":986},"obj":"UBERON_EXT:body"},{"id":"T2473","span":{"begin":1076,"end":1080},"obj":"UBERON:0001037"},{"id":"T2474","span":{"begin":1163,"end":1167},"obj":"UBERON:0001037"},{"id":"T2475","span":{"begin":1163,"end":1174},"obj":"GO:0042633"},{"id":"T2476","span":{"begin":1197,"end":1201},"obj":"UBERON:0001037"},{"id":"T2477","span":{"begin":1245,"end":1252},"obj":"CHEBI_EXT:26130"},{"id":"T2478","span":{"begin":1278,"end":1282},"obj":"NCBITaxon:10088"}],"text":"Semiquantitative measurements of hair length plotted as a function of dorsoventral position reveal that the apparent sharp boundary between dorsal and ventral pigment compartments in at/at mice coincides with a more gradual change in both hair color and hair length (Figure 1A–1D). Within the region of transition from dorsum to ventrum (Figure 1B), flank hairs from at/at mice become progressively shorter and exhibit increasing amounts of pheomelanin deposition progressing from the tip to the base of the hair. However, the region of transition for hair length is considerably broader than that for pigmentation and independent of Agouti genotype. Although hair-cycle timing varies along the rostrocaudal axis, measurements of absolute hair length for mice matched for age and rostrocaudal level are remarkably similar (Figure 1D). Furthermore, measurements of relative hair length for animals of different age, size, and Agouti genotype also are very similar when normalized to body circumference (Figure 1C). Taken together, these observations indicate that variation of hair length along the dorsoventral axis is stereotyped and maintained through multiple hair cycles, with a transition in hair length that is gradual and encompasses the pigment-type transition in at/at mice."}