PMC:314463 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T171	0-50	sentence	denotes	Dorsoventral Patterning of the Mouse Coat by Tbx15
T172	24-26	IN	denotes	of
T173	27-30	DT	denotes	the
T174	37-41	NN	denotes	Coat
T175	31-36	NN	denotes	Mouse
T176	42-44	IN	denotes	by
T177	45-50	NN	denotes	Tbx15
T178	100-205	sentence	denotes	Many members of the animal kingdom display coat or skin color differences along their dorsoventral axis.
T179	101-105	JJ	denotes	Many
T180	106-113	NNS	denotes	members
T181	136-143	VBP	denotes	display
T182	114-116	IN	denotes	of
T183	117-120	DT	denotes	the
T184	128-135	NN	denotes	kingdom
T185	121-127	NN	denotes	animal
T186	144-148	NN	denotes	coat
T187	163-174	NNS	denotes	differences
T188	149-151	CC	denotes	or
T189	152-156	NN	denotes	skin
T190	157-162	NN	denotes	color
T191	175-180	IN	denotes	along
T192	181-186	PRP$	denotes	their
T193	200-204	NN	denotes	axis
T194	187-199	JJ	denotes	dorsoventral
T195	204-205	.	denotes	.
T196	205-444	sentence	denotes	To determine the mechanisms that control regional differences in pigmentation, we have studied how a classical mouse mutation, droopy ear (deH), affects dorsoventral skin characteristics, especially those under control of the Agouti gene.
T197	206-208	TO	denotes	To
T198	209-218	VB	denotes	determine
T199	293-300	VBN	denotes	studied
T200	219-222	DT	denotes	the
T201	223-233	NNS	denotes	mechanisms
T202	234-238	WDT	denotes	that
T203	239-246	VBP	denotes	control
T204	247-255	JJ	denotes	regional
T205	256-267	NNS	denotes	differences
T206	268-270	IN	denotes	in
T207	271-283	NN	denotes	pigmentation
T208	283-285	,	denotes	,
T209	285-287	PRP	denotes	we
T210	288-292	VBP	denotes	have
T211	301-304	WRB	denotes	how
T212	351-358	VBZ	denotes	affects
T213	305-306	DT	denotes	a
T214	323-331	NN	denotes	mutation
T215	307-316	JJ	denotes	classical
T216	317-322	NN	denotes	mouse
T217	331-333	,	denotes	,
T218	333-339	JJ	denotes	droopy
T219	340-343	NN	denotes	ear
T220	344-345	-LRB-	denotes	(
T221	345-348	NN	denotes	deH
T222	348-349	-RRB-	denotes	)
T223	349-351	,	denotes	,
T224	359-371	JJ	denotes	dorsoventral
T225	377-392	NNS	denotes	characteristics
T226	372-376	NN	denotes	skin
T227	392-394	,	denotes	,
T228	394-404	RB	denotes	especially
T229	405-410	DT	denotes	those
T230	411-416	IN	denotes	under
T231	417-424	NN	denotes	control
T232	425-427	IN	denotes	of
T233	428-431	DT	denotes	the
T234	439-443	NN	denotes	gene
T235	432-438	NN	denotes	Agouti
T236	443-444	.	denotes	.
T237	444-684	sentence	denotes	Mice carrying the Agouti allele black-and-tan (at) normally have a sharp boundary between dorsal black hair and yellow ventral hair; the deH mutation raises the pigmentation boundary, producing an apparent dorsal-to-ventral transformation.
T238	445-449	NNS	denotes	Mice
T239	505-509	VBP	denotes	have
T240	450-458	VBG	denotes	carrying
T241	459-462	DT	denotes	the
T242	470-476	NN	denotes	allele
T243	463-469	NN	denotes	Agouti
T244	477-482	NN	denotes	black
T245	482-483	HYPH	denotes	-
T246	483-486	CC	denotes	and
T247	486-487	HYPH	denotes	-
T248	487-490	NN	denotes	tan
T249	491-492	-LRB-	denotes	(
T250	492-494	NN	denotes	at
T251	494-495	-RRB-	denotes	)
T252	496-504	RB	denotes	normally
T253	595-601	VBZ	denotes	raises
T254	510-511	DT	denotes	a
T255	518-526	NN	denotes	boundary
T256	512-517	JJ	denotes	sharp
T257	527-534	IN	denotes	between
T258	535-541	JJ	denotes	dorsal
T259	548-552	NN	denotes	hair
T260	542-547	JJ	denotes	black
T261	553-556	CC	denotes	and
T262	557-563	JJ	denotes	yellow
T263	572-576	NN	denotes	hair
T264	564-571	JJ	denotes	ventral
T265	576-577	:	denotes	;
T266	578-581	DT	denotes	the
T267	586-594	NN	denotes	mutation
T268	582-585	NN	denotes	deH
T269	602-605	DT	denotes	the
T270	619-627	NN	denotes	boundary
T271	606-618	NN	denotes	pigmentation
T272	627-629	,	denotes	,
T273	629-638	VBG	denotes	producing
T274	639-641	DT	denotes	an
T275	669-683	NN	denotes	transformation
T276	642-650	JJ	denotes	apparent
T277	651-657	JJ	denotes	dorsal
T278	657-658	HYPH	denotes	-
T279	658-660	IN	denotes	to
T280	660-661	HYPH	denotes	-
T281	661-668	JJ	denotes	ventral
T282	683-684	.	denotes	.
T283	684-911	sentence	denotes	We identify a 216 kb deletion in deH that removes all but the first exon of the Tbx15 gene, whose embryonic expression in developing mesenchyme correlates with pigmentary and skeletal malformations observed in deH/deH animals.
T284	685-687	PRP	denotes	We
T285	688-696	VBP	denotes	identify
T286	697-698	DT	denotes	a
T287	706-714	NN	denotes	deletion
T288	699-702	CD	denotes	216
T289	703-705	NN	denotes	kb
T290	715-717	IN	denotes	in
T291	718-721	NN	denotes	deH
T292	722-726	WDT	denotes	that
T293	727-734	VBZ	denotes	removes
T294	735-738	DT	denotes	all
T295	739-742	IN	denotes	but
T296	743-746	DT	denotes	the
T297	753-757	NN	denotes	exon
T298	747-752	JJ	denotes	first
T299	758-760	IN	denotes	of
T300	761-764	DT	denotes	the
T301	771-775	NN	denotes	gene
T302	765-770	NN	denotes	Tbx15
T303	775-777	,	denotes	,
T304	777-782	WP$	denotes	whose
T305	793-803	NN	denotes	expression
T306	783-792	JJ	denotes	embryonic
T307	829-839	VBZ	denotes	correlates
T308	804-806	IN	denotes	in
T309	807-817	VBG	denotes	developing
T310	818-828	NN	denotes	mesenchyme
T311	840-844	IN	denotes	with
T312	845-855	JJ	denotes	pigmentary
T313	869-882	NNS	denotes	malformations
T314	856-859	CC	denotes	and
T315	860-868	JJ	denotes	skeletal
T316	883-891	VBN	denotes	observed
T317	892-894	IN	denotes	in
T318	895-898	NN	denotes	deH
T319	899-902	NN	denotes	deH
T320	898-899	HYPH	denotes	/
T321	903-910	NNS	denotes	animals
T322	910-911	.	denotes	.
T323	911-1025	sentence	denotes	Construction of a targeted allele of Tbx15 confirmed that the deH phenotype was caused by Tbx15 loss of function.
T324	912-924	NN	denotes	Construction
T325	955-964	VBD	denotes	confirmed
T326	925-927	IN	denotes	of
T327	928-929	DT	denotes	a
T328	939-945	NN	denotes	allele
T329	930-938	VBN	denotes	targeted
T330	946-948	IN	denotes	of
T331	949-954	NN	denotes	Tbx15
T332	965-969	IN	denotes	that
T333	992-998	VBN	denotes	caused
T334	970-973	DT	denotes	the
T335	978-987	NN	denotes	phenotype
T336	974-977	NN	denotes	deH
T337	988-991	VBD	denotes	was
T338	999-1001	IN	denotes	by
T339	1002-1007	NN	denotes	Tbx15
T340	1008-1012	NN	denotes	loss
T341	1013-1015	IN	denotes	of
T342	1016-1024	NN	denotes	function
T343	1024-1025	.	denotes	.
T344	1025-1250	sentence	denotes	Early embryonic expression of Tbx15 in dorsal mesenchyme is complementary to Agouti expression in ventral mesenchyme; in the absence of Tbx15, expression of Agouti in both embryos and postnatal animals is displaced dorsally.
T345	1026-1031	RB	denotes	Early
T346	1032-1041	JJ	denotes	embryonic
T347	1042-1052	NN	denotes	expression
T348	1083-1085	VBZ	denotes	is
T349	1053-1055	IN	denotes	of
T350	1056-1061	NN	denotes	Tbx15
T351	1062-1064	IN	denotes	in
T352	1065-1071	JJ	denotes	dorsal
T353	1072-1082	NN	denotes	mesenchyme
T354	1231-1240	VBN	denotes	displaced
T355	1086-1099	JJ	denotes	complementary
T356	1100-1102	IN	denotes	to
T357	1103-1109	NN	denotes	Agouti
T358	1110-1120	NN	denotes	expression
T359	1121-1123	IN	denotes	in
T360	1124-1131	JJ	denotes	ventral
T361	1132-1142	NN	denotes	mesenchyme
T362	1142-1143	:	denotes	;
T363	1144-1146	IN	denotes	in
T364	1147-1150	DT	denotes	the
T365	1151-1158	NN	denotes	absence
T366	1159-1161	IN	denotes	of
T367	1162-1167	NN	denotes	Tbx15
T368	1167-1169	,	denotes	,
T369	1169-1179	NN	denotes	expression
T370	1180-1182	IN	denotes	of
T371	1183-1189	NN	denotes	Agouti
T372	1190-1192	IN	denotes	in
T373	1193-1197	CC	denotes	both
T374	1198-1205	NNS	denotes	embryos
T375	1206-1209	CC	denotes	and
T376	1210-1219	JJ	denotes	postnatal
T377	1220-1227	NNS	denotes	animals
T378	1228-1230	VBZ	denotes	is
T379	1241-1249	RB	denotes	dorsally
T380	1249-1250	.	denotes	.
T381	1250-1462	sentence	denotes	Transplantation experiments demonstrate that positional identity of the skin with regard to dorsoventral pigmentation differences is acquired by E12.5, which is shortly after early embryonic expression of Tbx15.
T382	1251-1266	NN	denotes	Transplantation
T383	1267-1278	NNS	denotes	experiments
T384	1279-1290	VBP	denotes	demonstrate
T385	1291-1295	IN	denotes	that
T386	1384-1392	VBN	denotes	acquired
T387	1296-1306	JJ	denotes	positional
T388	1307-1315	NN	denotes	identity
T389	1316-1318	IN	denotes	of
T390	1319-1322	DT	denotes	the
T391	1323-1327	NN	denotes	skin
T392	1328-1332	IN	denotes	with
T393	1333-1339	NN	denotes	regard
T394	1340-1342	IN	denotes	to
T395	1343-1355	JJ	denotes	dorsoventral
T396	1369-1380	NNS	denotes	differences
T397	1356-1368	NN	denotes	pigmentation
T398	1381-1383	VBZ	denotes	is
T399	1393-1395	IN	denotes	by
T400	1396-1401	NN	denotes	E12.5
T401	1401-1403	,	denotes	,
T402	1403-1408	WDT	denotes	which
T403	1409-1411	VBZ	denotes	is
T404	1412-1419	RB	denotes	shortly
T405	1420-1425	IN	denotes	after
T406	1426-1431	RB	denotes	early
T407	1432-1441	JJ	denotes	embryonic
T408	1442-1452	NN	denotes	expression
T409	1453-1455	IN	denotes	of
T410	1456-1461	NN	denotes	Tbx15
T411	1461-1462	.	denotes	.
T412	1462-1658	sentence	denotes	Fate-mapping studies show that the dorsoventral pigmentation boundary is not in register with a previously identified dermal cell lineage boundary, but rather with the limb dorsoventral boundary.
T413	1463-1467	NN	denotes	Fate
T414	1468-1475	VBG	denotes	mapping
T415	1467-1468	HYPH	denotes	-
T416	1476-1483	NNS	denotes	studies
T417	1484-1488	VBP	denotes	show
T418	1489-1493	IN	denotes	that
T419	1533-1535	VBZ	denotes	is
T420	1494-1497	DT	denotes	the
T421	1524-1532	NN	denotes	boundary
T422	1498-1510	JJ	denotes	dorsoventral
T423	1511-1523	NN	denotes	pigmentation
T424	1536-1539	RB	denotes	not
T425	1540-1542	IN	denotes	in
T426	1543-1551	NN	denotes	register
T427	1552-1556	IN	denotes	with
T428	1557-1558	DT	denotes	a
T429	1601-1609	NN	denotes	boundary
T430	1559-1569	RB	denotes	previously
T431	1570-1580	VBN	denotes	identified
T432	1581-1587	JJ	denotes	dermal
T433	1588-1592	NN	denotes	cell
T434	1593-1600	NN	denotes	lineage
T435	1609-1611	,	denotes	,
T436	1611-1614	CC	denotes	but
T437	1615-1621	RB	denotes	rather
T438	1622-1626	IN	denotes	with
T439	1627-1630	DT	denotes	the
T440	1649-1657	NN	denotes	boundary
T441	1631-1635	NN	denotes	limb
T442	1636-1648	JJ	denotes	dorsoventral
T443	1657-1658	.	denotes	.
T444	1658-1816	sentence	denotes	Embryonic expression of Tbx15 in dorsolateral mesenchyme provides an instructional cue required to establish the future positional identity of dorsal dermis.
T445	1659-1668	JJ	denotes	Embryonic
T446	1669-1679	NN	denotes	expression
T447	1716-1724	VBZ	denotes	provides
T448	1680-1682	IN	denotes	of
T449	1683-1688	NN	denotes	Tbx15
T450	1689-1691	IN	denotes	in
T451	1692-1704	JJ	denotes	dorsolateral
T452	1705-1715	NN	denotes	mesenchyme
T453	1725-1727	DT	denotes	an
T454	1742-1745	NN	denotes	cue
T455	1728-1741	JJ	denotes	instructional
T456	1746-1754	VBN	denotes	required
T457	1755-1757	TO	denotes	to
T458	1758-1767	VB	denotes	establish
T459	1768-1771	DT	denotes	the
T460	1790-1798	NN	denotes	identity
T461	1772-1778	JJ	denotes	future
T462	1779-1789	JJ	denotes	positional
T463	1799-1801	IN	denotes	of
T464	1802-1808	JJ	denotes	dorsal
T465	1809-1815	NN	denotes	dermis
T466	1815-1816	.	denotes	.
T467	1816-2120	sentence	denotes	These findings represent a novel role for T-box gene action in embryonic development, identify a previously unappreciated aspect of dorsoventral patterning that is widely represented in furred mammals, and provide insight into the mechanisms that underlie region-specific differences in body morphology.
T468	1817-1822	DT	denotes	These
T469	1823-1831	NNS	denotes	findings
T470	1832-1841	VBP	denotes	represent
T471	1842-1843	DT	denotes	a
T472	1850-1854	NN	denotes	role
T473	1844-1849	JJ	denotes	novel
T474	1855-1858	IN	denotes	for
T475	1859-1860	NN	denotes	T
T476	1861-1864	NN	denotes	box
T477	1860-1861	HYPH	denotes	-
T478	1870-1876	NN	denotes	action
T479	1865-1869	NN	denotes	gene
T480	1877-1879	IN	denotes	in
T481	1880-1889	JJ	denotes	embryonic
T482	1890-1901	NN	denotes	development
T483	1901-1903	,	denotes	,
T484	1903-1911	VBP	denotes	identify
T485	1912-1913	DT	denotes	a
T486	1939-1945	NN	denotes	aspect
T487	1914-1924	RB	denotes	previously
T488	1925-1938	JJ	denotes	unappreciated
T489	1946-1948	IN	denotes	of
T490	1949-1961	JJ	denotes	dorsoventral
T491	1962-1972	NN	denotes	patterning
T492	1973-1977	WDT	denotes	that
T493	1988-1999	VBN	denotes	represented
T494	1978-1980	VBZ	denotes	is
T495	1981-1987	RB	denotes	widely
T496	2000-2002	IN	denotes	in
T497	2003-2009	VBN	denotes	furred
T498	2010-2017	NNS	denotes	mammals
T499	2017-2019	,	denotes	,
T500	2019-2022	CC	denotes	and
T501	2023-2030	VBP	denotes	provide
T502	2031-2038	NN	denotes	insight
T503	2039-2043	IN	denotes	into
T504	2044-2047	DT	denotes	the
T505	2048-2058	NNS	denotes	mechanisms
T506	2059-2063	WDT	denotes	that
T507	2064-2072	VBP	denotes	underlie
T508	2073-2079	NN	denotes	region
T509	2080-2088	JJ	denotes	specific
T510	2079-2080	HYPH	denotes	-
T511	2089-2100	NNS	denotes	differences
T512	2101-2103	IN	denotes	in
T513	2104-2108	NN	denotes	body
T514	2109-2119	NN	denotes	morphology
T515	2119-2120	.	denotes	.
T992	2278-2279	DT	denotes	A
T993	2292-2300	NN	denotes	question
T994	2280-2291	JJ	denotes	fundamental
T995	2326-2328	VBZ	denotes	is
T996	2301-2303	IN	denotes	in
T997	2304-2317	JJ	denotes	developmental
T998	2318-2325	NN	denotes	biology
T999	2329-2332	WRB	denotes	how
T1000	2373-2380	VBP	denotes	acquire
T1001	2333-2341	JJ	denotes	adjacent
T1002	2342-2349	NNS	denotes	regions
T1003	2350-2352	IN	denotes	of
T1004	2353-2356	DT	denotes	the
T1005	2368-2372	NN	denotes	body
T1006	2357-2367	NN	denotes	vertebrate
T1007	2381-2392	NNS	denotes	differences
T1008	2393-2395	IN	denotes	in
T1009	2396-2401	PRP$	denotes	their
T1010	2402-2412	NN	denotes	appearance
T1011	2413-2415	CC	denotes	or
T1012	2416-2426	NN	denotes	morphology
T1013	2426-2427	.	denotes	.
T1014	2427-2705	sentence	denotes	Mechanisms that establish the general body plan make use of a relatively small number of signaling pathways shared among all animals (reviewed in Pires-daSilva and Sommer 2003), but the extent to which these pathways control finer differences between body regions is not clear.
T1015	2428-2438	NNS	denotes	Mechanisms
T1016	2476-2480	VBP	denotes	make
T1017	2439-2443	WDT	denotes	that
T1018	2444-2453	VBP	denotes	establish
T1019	2454-2457	DT	denotes	the
T1020	2471-2475	NN	denotes	plan
T1021	2458-2465	JJ	denotes	general
T1022	2466-2470	NN	denotes	body
T1023	2481-2484	NN	denotes	use
T1024	2485-2487	IN	denotes	of
T1025	2488-2489	DT	denotes	a
T1026	2507-2513	NN	denotes	number
T1027	2490-2500	RB	denotes	relatively
T1028	2501-2506	JJ	denotes	small
T1029	2514-2516	IN	denotes	of
T1030	2517-2526	NN	denotes	signaling
T1031	2527-2535	NNS	denotes	pathways
T1032	2536-2542	VBN	denotes	shared
T1033	2543-2548	IN	denotes	among
T1034	2549-2552	DT	denotes	all
T1035	2553-2560	NNS	denotes	animals
T1036	2561-2562	-LRB-	denotes	(
T1037	2562-2570	VBN	denotes	reviewed
T1038	2571-2573	IN	denotes	in
T1039	2574-2579	NNP	denotes	Pires
T1040	2580-2587	NNP	denotes	daSilva
T1041	2579-2580	HYPH	denotes	-
T1042	2588-2591	CC	denotes	and
T1043	2592-2598	NNP	denotes	Sommer
T1044	2599-2603	CD	denotes	2003
T1045	2603-2604	-RRB-	denotes	)
T1046	2604-2606	,	denotes	,
T1047	2606-2609	CC	denotes	but
T1048	2610-2613	DT	denotes	the
T1049	2614-2620	NN	denotes	extent
T1050	2692-2694	VBZ	denotes	is
T1051	2621-2623	IN	denotes	to
T1052	2645-2652	VBP	denotes	control
T1053	2624-2629	WDT	denotes	which
T1054	2630-2635	DT	denotes	these
T1055	2636-2644	NNS	denotes	pathways
T1056	2653-2658	JJR	denotes	finer
T1057	2659-2670	NNS	denotes	differences
T1058	2671-2678	IN	denotes	between
T1059	2679-2683	NN	denotes	body
T1060	2684-2691	NNS	denotes	regions
T1061	2695-2698	RB	denotes	not
T1062	2699-2704	JJ	denotes	clear
T1063	2704-2705	.	denotes	.
T1064	2705-2942	sentence	denotes	Among vertebrates, differences in the shape or number of skeletal elements, altered morphology of epidermal appendages, and variation in pigment distribution combine to produce the majority of what distinguishes one animal from another.
T1065	2706-2711	IN	denotes	Among
T1066	2864-2871	VBP	denotes	combine
T1067	2712-2723	NNS	denotes	vertebrates
T1068	2723-2725	,	denotes	,
T1069	2725-2736	NNS	denotes	differences
T1070	2737-2739	IN	denotes	in
T1071	2740-2743	DT	denotes	the
T1072	2744-2749	NN	denotes	shape
T1073	2750-2752	CC	denotes	or
T1074	2753-2759	NN	denotes	number
T1075	2760-2762	IN	denotes	of
T1076	2763-2771	JJ	denotes	skeletal
T1077	2772-2780	NNS	denotes	elements
T1078	2780-2782	,	denotes	,
T1079	2782-2789	JJ	denotes	altered
T1080	2790-2800	NN	denotes	morphology
T1081	2801-2803	IN	denotes	of
T1082	2804-2813	JJ	denotes	epidermal
T1083	2814-2824	NNS	denotes	appendages
T1084	2824-2826	,	denotes	,
T1085	2826-2829	CC	denotes	and
T1086	2830-2839	NN	denotes	variation
T1087	2840-2842	IN	denotes	in
T1088	2843-2850	NN	denotes	pigment
T1089	2851-2863	NN	denotes	distribution
T1090	2872-2874	TO	denotes	to
T1091	2875-2882	VB	denotes	produce
T1092	2883-2886	DT	denotes	the
T1093	2887-2895	NN	denotes	majority
T1094	2896-2898	IN	denotes	of
T1095	2899-2903	WP	denotes	what
T1096	2904-2917	VBZ	denotes	distinguishes
T1097	2918-2921	CD	denotes	one
T1098	2922-2928	NN	denotes	animal
T1099	2929-2933	IN	denotes	from
T1100	2934-2941	DT	denotes	another
T1101	2941-2942	.	denotes	.
T1102	2942-3160	sentence	denotes	Among these, pigment patterns are an excellent system to investigate how morphological differences arise, both for different regions of the body within a species and for different animals from closely related species.
T1103	2943-2948	IN	denotes	Among
T1104	2973-2976	VBP	denotes	are
T1105	2949-2954	DT	denotes	these
T1106	2954-2956	,	denotes	,
T1107	2956-2963	NN	denotes	pigment
T1108	2964-2972	NNS	denotes	patterns
T1109	2977-2979	DT	denotes	an
T1110	2990-2996	NN	denotes	system
T1111	2980-2989	JJ	denotes	excellent
T1112	2997-2999	TO	denotes	to
T1113	3000-3011	VB	denotes	investigate
T1114	3012-3015	WRB	denotes	how
T1115	3042-3047	VBP	denotes	arise
T1116	3016-3029	JJ	denotes	morphological
T1117	3030-3041	NNS	denotes	differences
T1118	3047-3049	,	denotes	,
T1119	3049-3053	CC	denotes	both
T1120	3054-3057	IN	denotes	for
T1121	3058-3067	JJ	denotes	different
T1122	3068-3075	NNS	denotes	regions
T1123	3076-3078	IN	denotes	of
T1124	3079-3082	DT	denotes	the
T1125	3083-3087	NN	denotes	body
T1126	3088-3094	IN	denotes	within
T1127	3095-3096	DT	denotes	a
T1128	3097-3104	NN	denotes	species
T1129	3105-3108	CC	denotes	and
T1130	3109-3112	IN	denotes	for
T1131	3113-3122	JJ	denotes	different
T1132	3123-3130	NNS	denotes	animals
T1133	3131-3135	IN	denotes	from
T1134	3136-3143	RB	denotes	closely
T1135	3144-3151	JJ	denotes	related
T1136	3152-3159	NNS	denotes	species
T1137	3159-3160	.	denotes	.
T1138	3160-3430	sentence	denotes	In natural environments, color variation is a nearly universal mechanism for recognition, camouflage, or both; consequently, a large number of pigment patterns have been characterized from an evolutionary and ecological perspective (Boughman 2001; Jiggins et al. 2001).
T1139	3161-3163	IN	denotes	In
T1140	3202-3204	VBZ	denotes	is
T1141	3164-3171	JJ	denotes	natural
T1142	3172-3184	NNS	denotes	environments
T1143	3184-3186	,	denotes	,
T1144	3186-3191	NN	denotes	color
T1145	3192-3201	NN	denotes	variation
T1146	3331-3344	VBN	denotes	characterized
T1147	3205-3206	DT	denotes	a
T1148	3224-3233	NN	denotes	mechanism
T1149	3207-3213	RB	denotes	nearly
T1150	3214-3223	JJ	denotes	universal
T1151	3234-3237	IN	denotes	for
T1152	3238-3249	NN	denotes	recognition
T1153	3249-3251	,	denotes	,
T1154	3251-3261	NN	denotes	camouflage
T1155	3261-3263	,	denotes	,
T1156	3263-3265	CC	denotes	or
T1157	3266-3270	DT	denotes	both
T1158	3270-3271	:	denotes	;
T1159	3272-3284	RB	denotes	consequently
T1160	3284-3286	,	denotes	,
T1161	3286-3287	DT	denotes	a
T1162	3294-3300	NN	denotes	number
T1163	3288-3293	JJ	denotes	large
T1164	3301-3303	IN	denotes	of
T1165	3304-3311	NN	denotes	pigment
T1166	3312-3320	NNS	denotes	patterns
T1167	3321-3325	VBP	denotes	have
T1168	3326-3330	VBN	denotes	been
T1169	3345-3349	IN	denotes	from
T1170	3350-3352	DT	denotes	an
T1171	3381-3392	NN	denotes	perspective
T1172	3353-3365	JJ	denotes	evolutionary
T1173	3366-3369	CC	denotes	and
T1174	3370-3380	JJ	denotes	ecological
T1175	3393-3394	-LRB-	denotes	(
T1176	3394-3402	NNP	denotes	Boughman
T1177	3403-3407	CD	denotes	2001
T1178	3407-3408	:	denotes	;
T1179	3409-3416	NNP	denotes	Jiggins
T1180	3417-3419	FW	denotes	et
T1181	3420-3423	FW	denotes	al.
T1182	3424-3428	CD	denotes	2001
T1183	3428-3429	-RRB-	denotes	)
T1184	3429-3430	.	denotes	.
T1185	3430-3721	sentence	denotes	In the laboratory, color variation has been the subject of vertebrate genetics for more than a century (Searle 1968; Silvers 1979), and many pigmentary components have been identified whose actions are understood in a cellular or organ-based context (reviewed in Bennett and Lamoreux 2003).
T1186	3431-3433	IN	denotes	In
T1187	3470-3474	VBN	denotes	been
T1188	3434-3437	DT	denotes	the
T1189	3438-3448	NN	denotes	laboratory
T1190	3448-3450	,	denotes	,
T1191	3450-3455	NN	denotes	color
T1192	3456-3465	NN	denotes	variation
T1193	3466-3469	VBZ	denotes	has
T1194	3475-3478	DT	denotes	the
T1195	3479-3486	NN	denotes	subject
T1196	3487-3489	IN	denotes	of
T1197	3490-3500	NN	denotes	vertebrate
T1198	3501-3509	NN	denotes	genetics
T1199	3510-3513	IN	denotes	for
T1200	3514-3518	JJR	denotes	more
T1201	3524-3525	DT	denotes	a
T1202	3519-3523	IN	denotes	than
T1203	3526-3533	NN	denotes	century
T1204	3534-3535	-LRB-	denotes	(
T1205	3535-3541	NNP	denotes	Searle
T1206	3542-3546	CD	denotes	1968
T1207	3546-3547	:	denotes	;
T1208	3548-3555	NNP	denotes	Silvers
T1209	3556-3560	CD	denotes	1979
T1210	3560-3561	-RRB-	denotes	)
T1211	3561-3563	,	denotes	,
T1212	3563-3566	CC	denotes	and
T1213	3567-3571	JJ	denotes	many
T1214	3583-3593	NNS	denotes	components
T1215	3572-3582	JJ	denotes	pigmentary
T1216	3604-3614	VBN	denotes	identified
T1217	3594-3598	VBP	denotes	have
T1218	3599-3603	VBN	denotes	been
T1219	3615-3620	WP$	denotes	whose
T1220	3621-3628	NNS	denotes	actions
T1221	3633-3643	VBN	denotes	understood
T1222	3629-3632	VBP	denotes	are
T1223	3644-3646	IN	denotes	in
T1224	3647-3648	DT	denotes	a
T1225	3673-3680	NN	denotes	context
T1226	3649-3657	JJ	denotes	cellular
T1227	3658-3660	CC	denotes	or
T1228	3661-3666	NN	denotes	organ
T1229	3667-3672	VBN	denotes	based
T1230	3666-3667	HYPH	denotes	-
T1231	3681-3682	-LRB-	denotes	(
T1232	3682-3690	VBN	denotes	reviewed
T1233	3691-3693	IN	denotes	in
T1234	3694-3701	NNP	denotes	Bennett
T1235	3702-3705	CC	denotes	and
T1236	3706-3714	NNP	denotes	Lamoreux
T1237	3715-3719	CD	denotes	2003
T1238	3719-3720	-RRB-	denotes	)
T1239	3720-3721	.	denotes	.
T1240	3721-3807	sentence	denotes	Several mechanisms may contribute to regional differences in vertebrate pigmentation.
T1241	3722-3729	JJ	denotes	Several
T1242	3730-3740	NNS	denotes	mechanisms
T1243	3745-3755	VB	denotes	contribute
T1244	3741-3744	MD	denotes	may
T1245	3756-3758	IN	denotes	to
T1246	3759-3767	JJ	denotes	regional
T1247	3768-3779	NNS	denotes	differences
T1248	3780-3782	IN	denotes	in
T1249	3783-3793	NN	denotes	vertebrate
T1250	3794-3806	NN	denotes	pigmentation
T1251	3806-3807	.	denotes	.
T1252	3807-4002	sentence	denotes	In the embryo, alterations in the determination or migration of melanoblasts from the neural crest affect the number or distribution of pigment cells in the skin (reviewed in Reedy et al. 1998).
T1253	3808-3810	IN	denotes	In
T1254	3907-3913	VBP	denotes	affect
T1255	3811-3814	DT	denotes	the
T1256	3815-3821	NN	denotes	embryo
T1257	3821-3823	,	denotes	,
T1258	3823-3834	NNS	denotes	alterations
T1259	3835-3837	IN	denotes	in
T1260	3838-3841	DT	denotes	the
T1261	3842-3855	NN	denotes	determination
T1262	3856-3858	CC	denotes	or
T1263	3859-3868	NN	denotes	migration
T1264	3869-3871	IN	denotes	of
T1265	3872-3884	NNS	denotes	melanoblasts
T1266	3885-3889	IN	denotes	from
T1267	3890-3893	DT	denotes	the
T1268	3901-3906	NN	denotes	crest
T1269	3894-3900	JJ	denotes	neural
T1270	3914-3917	DT	denotes	the
T1271	3918-3924	NN	denotes	number
T1272	3925-3927	CC	denotes	or
T1273	3928-3940	NN	denotes	distribution
T1274	3941-3943	IN	denotes	of
T1275	3944-3951	NN	denotes	pigment
T1276	3952-3957	NNS	denotes	cells
T1277	3958-3960	IN	denotes	in
T1278	3961-3964	DT	denotes	the
T1279	3965-3969	NN	denotes	skin
T1280	3970-3971	-LRB-	denotes	(
T1281	3971-3979	VBN	denotes	reviewed
T1282	3980-3982	IN	denotes	in
T1283	3983-3988	NNP	denotes	Reedy
T1284	3989-3991	FW	denotes	et
T1285	3992-3995	FW	denotes	al.
T1286	3996-4000	CD	denotes	1998
T1287	4000-4001	-RRB-	denotes	)
T1288	4001-4002	.	denotes	.
T1289	4002-4206	sentence	denotes	Within hair follicles, paracrine signals control the type of pigment made in specific regions of the body or at specific times during the hair cycle (reviewed in Furumura et al. 1996; Barsh et al. 2000).
T1290	4003-4009	IN	denotes	Within
T1291	4044-4051	VBP	denotes	control
T1292	4010-4014	NN	denotes	hair
T1293	4015-4024	NNS	denotes	follicles
T1294	4024-4026	,	denotes	,
T1295	4026-4035	JJ	denotes	paracrine
T1296	4036-4043	NNS	denotes	signals
T1297	4052-4055	DT	denotes	the
T1298	4056-4060	NN	denotes	type
T1299	4061-4063	IN	denotes	of
T1300	4064-4071	NN	denotes	pigment
T1301	4072-4076	VBN	denotes	made
T1302	4077-4079	IN	denotes	in
T1303	4080-4088	JJ	denotes	specific
T1304	4089-4096	NNS	denotes	regions
T1305	4097-4099	IN	denotes	of
T1306	4100-4103	DT	denotes	the
T1307	4104-4108	NN	denotes	body
T1308	4109-4111	CC	denotes	or
T1309	4112-4114	IN	denotes	at
T1310	4115-4123	JJ	denotes	specific
T1311	4124-4129	NNS	denotes	times
T1312	4130-4136	IN	denotes	during
T1313	4137-4140	DT	denotes	the
T1314	4146-4151	NN	denotes	cycle
T1315	4141-4145	NN	denotes	hair
T1316	4152-4153	-LRB-	denotes	(
T1317	4153-4161	VBN	denotes	reviewed
T1318	4162-4164	IN	denotes	in
T1319	4165-4173	NNP	denotes	Furumura
T1320	4174-4176	FW	denotes	et
T1321	4177-4180	FW	denotes	al.
T1322	4181-4185	CD	denotes	1996
T1323	4185-4186	:	denotes	;
T1324	4187-4192	NNP	denotes	Barsh
T1325	4193-4195	FW	denotes	et
T1326	4196-4199	FW	denotes	al.
T1327	4200-4204	CD	denotes	2000
T1328	4204-4205	-RRB-	denotes	)
T1329	4205-4206	.	denotes	.
T1330	4206-4463	sentence	denotes	Finally, movement of pigment granules within melanocytes or from melanocytes to keratinocytes makes use of cellular machinery that is shared by a variety of cell types, but that can vary in different regions of the body (reviewed in Marks and Seabra 2001).
T1331	4207-4214	RB	denotes	Finally
T1332	4301-4306	VBZ	denotes	makes
T1333	4214-4216	,	denotes	,
T1334	4216-4224	NN	denotes	movement
T1335	4225-4227	IN	denotes	of
T1336	4228-4235	NN	denotes	pigment
T1337	4236-4244	NNS	denotes	granules
T1338	4245-4251	IN	denotes	within
T1339	4252-4263	NNS	denotes	melanocytes
T1340	4264-4266	CC	denotes	or
T1341	4267-4271	IN	denotes	from
T1342	4272-4283	NNS	denotes	melanocytes
T1343	4284-4286	IN	denotes	to
T1344	4287-4300	NNS	denotes	keratinocytes
T1345	4307-4310	NN	denotes	use
T1346	4311-4313	IN	denotes	of
T1347	4314-4322	JJ	denotes	cellular
T1348	4323-4332	NN	denotes	machinery
T1349	4333-4337	WDT	denotes	that
T1350	4341-4347	VBN	denotes	shared
T1351	4338-4340	VBZ	denotes	is
T1352	4348-4350	IN	denotes	by
T1353	4351-4352	DT	denotes	a
T1354	4353-4360	NN	denotes	variety
T1355	4361-4363	IN	denotes	of
T1356	4364-4368	NN	denotes	cell
T1357	4369-4374	NNS	denotes	types
T1358	4374-4376	,	denotes	,
T1359	4376-4379	CC	denotes	but
T1360	4380-4384	DT	denotes	that
T1361	4389-4393	VB	denotes	vary
T1362	4385-4388	MD	denotes	can
T1363	4394-4396	IN	denotes	in
T1364	4397-4406	JJ	denotes	different
T1365	4407-4414	NNS	denotes	regions
T1366	4415-4417	IN	denotes	of
T1367	4418-4421	DT	denotes	the
T1368	4422-4426	NN	denotes	body
T1369	4427-4428	-LRB-	denotes	(
T1370	4428-4436	VBN	denotes	reviewed
T1371	4437-4439	IN	denotes	in
T1372	4440-4445	NNP	denotes	Marks
T1373	4446-4449	CC	denotes	and
T1374	4450-4456	NNP	denotes	Seabra
T1375	4457-4461	CD	denotes	2001
T1376	4461-4462	-RRB-	denotes	)
T1377	4462-4463	.	denotes	.
T1378	4463-4668	sentence	denotes	However, for all of these mechanisms—white spotting, pigment-type switching, and melanosome biogenesis—more is known about the identity of the molecular components than their spatial and temporal control.
T1379	4464-4471	RB	denotes	However
T1380	4575-4580	VBN	denotes	known
T1381	4471-4473	,	denotes	,
T1382	4473-4476	IN	denotes	for
T1383	4477-4480	DT	denotes	all
T1384	4481-4483	IN	denotes	of
T1385	4484-4489	DT	denotes	these
T1386	4490-4500	NNS	denotes	mechanisms
T1387	4500-4501	HYPH	denotes	—
T1388	4501-4506	JJ	denotes	white
T1389	4507-4515	NN	denotes	spotting
T1390	4515-4517	,	denotes	,
T1391	4517-4524	NN	denotes	pigment
T1392	4525-4529	NN	denotes	type
T1393	4524-4525	HYPH	denotes	-
T1394	4530-4539	VBG	denotes	switching
T1395	4539-4541	,	denotes	,
T1396	4541-4544	CC	denotes	and
T1397	4545-4555	NN	denotes	melanosome
T1398	4556-4566	NN	denotes	biogenesis
T1399	4566-4567	HYPH	denotes	—
T1400	4567-4571	JJR	denotes	more
T1401	4572-4574	VBZ	denotes	is
T1402	4581-4586	IN	denotes	about
T1403	4587-4590	DT	denotes	the
T1404	4591-4599	NN	denotes	identity
T1405	4600-4602	IN	denotes	of
T1406	4603-4606	DT	denotes	the
T1407	4617-4627	NNS	denotes	components
T1408	4607-4616	JJ	denotes	molecular
T1409	4628-4632	IN	denotes	than
T1410	4633-4638	PRP$	denotes	their
T1411	4660-4667	NN	denotes	control
T1412	4639-4646	JJ	denotes	spatial
T1413	4647-4650	CC	denotes	and
T1414	4651-4659	JJ	denotes	temporal
T1415	4667-4668	.	denotes	.
T1416	4668-4979	sentence	denotes	One of the most obvious aspects of regional color variation in vertebrates is a dark dorsal surface juxtaposed to a light ventral surface, apparent in the color of skin, scales, feathers, or hair, in which the boundary between dorsal and ventral compartments is often sharp and lies in register with the limbs.
T1417	4669-4672	CD	denotes	One
T1418	4744-4746	VBZ	denotes	is
T1419	4673-4675	IN	denotes	of
T1420	4676-4679	DT	denotes	the
T1421	4693-4700	NNS	denotes	aspects
T1422	4680-4684	RBS	denotes	most
T1423	4685-4692	JJ	denotes	obvious
T1424	4701-4703	IN	denotes	of
T1425	4704-4712	JJ	denotes	regional
T1426	4719-4728	NN	denotes	variation
T1427	4713-4718	NN	denotes	color
T1428	4729-4731	IN	denotes	in
T1429	4732-4743	NNS	denotes	vertebrates
T1430	4747-4748	DT	denotes	a
T1431	4761-4768	NN	denotes	surface
T1432	4749-4753	JJ	denotes	dark
T1433	4754-4760	JJ	denotes	dorsal
T1434	4769-4779	VBN	denotes	juxtaposed
T1435	4780-4782	IN	denotes	to
T1436	4783-4784	DT	denotes	a
T1437	4799-4806	NN	denotes	surface
T1438	4785-4790	JJ	denotes	light
T1439	4791-4798	JJ	denotes	ventral
T1440	4806-4808	,	denotes	,
T1441	4808-4816	JJ	denotes	apparent
T1442	4817-4819	IN	denotes	in
T1443	4820-4823	DT	denotes	the
T1444	4824-4829	NN	denotes	color
T1445	4830-4832	IN	denotes	of
T1446	4833-4837	NN	denotes	skin
T1447	4837-4839	,	denotes	,
T1448	4839-4845	NNS	denotes	scales
T1449	4845-4847	,	denotes	,
T1450	4847-4855	NNS	denotes	feathers
T1451	4855-4857	,	denotes	,
T1452	4857-4859	CC	denotes	or
T1453	4860-4864	NN	denotes	hair
T1454	4864-4866	,	denotes	,
T1455	4866-4868	IN	denotes	in
T1456	4928-4930	VBZ	denotes	is
T1457	4869-4874	WDT	denotes	which
T1458	4875-4878	DT	denotes	the
T1459	4879-4887	NN	denotes	boundary
T1460	4888-4895	IN	denotes	between
T1461	4896-4902	JJ	denotes	dorsal
T1462	4915-4927	NNS	denotes	compartments
T1463	4903-4906	CC	denotes	and
T1464	4907-4914	JJ	denotes	ventral
T1465	4931-4936	RB	denotes	often
T1466	4937-4942	JJ	denotes	sharp
T1467	4943-4946	CC	denotes	and
T1468	4947-4951	VBZ	denotes	lies
T1469	4952-4954	IN	denotes	in
T1470	4955-4963	NN	denotes	register
T1471	4964-4968	IN	denotes	with
T1472	4969-4972	DT	denotes	the
T1473	4973-4978	NNS	denotes	limbs
T1474	4978-4979	.	denotes	.
T1475	4979-5206	sentence	denotes	In rodents and probably other mammals, this dorsoventral difference in hair color is brought about by differences in pigment type as determined by allelic variation of the Agouti gene (Bultman et al. 1992; Miller et al. 1993).
T1476	4980-4982	IN	denotes	In
T1477	5065-5072	VBN	denotes	brought
T1478	4983-4990	NNS	denotes	rodents
T1479	4991-4994	CC	denotes	and
T1480	4995-5003	RB	denotes	probably
T1481	5010-5017	NNS	denotes	mammals
T1482	5004-5009	JJ	denotes	other
T1483	5017-5019	,	denotes	,
T1484	5019-5023	DT	denotes	this
T1485	5037-5047	NN	denotes	difference
T1486	5024-5036	JJ	denotes	dorsoventral
T1487	5048-5050	IN	denotes	in
T1488	5051-5055	NN	denotes	hair
T1489	5056-5061	NN	denotes	color
T1490	5062-5064	VBZ	denotes	is
T1491	5073-5078	RP	denotes	about
T1492	5079-5081	IN	denotes	by
T1493	5082-5093	NNS	denotes	differences
T1494	5094-5096	IN	denotes	in
T1495	5097-5104	NN	denotes	pigment
T1496	5105-5109	NN	denotes	type
T1497	5110-5112	IN	denotes	as
T1498	5113-5123	VBN	denotes	determined
T1499	5124-5126	IN	denotes	by
T1500	5127-5134	JJ	denotes	allelic
T1501	5135-5144	NN	denotes	variation
T1502	5145-5147	IN	denotes	of
T1503	5148-5151	DT	denotes	the
T1504	5159-5163	NN	denotes	gene
T1505	5152-5158	NN	denotes	Agouti
T1506	5164-5165	-LRB-	denotes	(
T1507	5165-5172	NNP	denotes	Bultman
T1508	5173-5175	FW	denotes	et
T1509	5176-5179	FW	denotes	al.
T1510	5180-5184	CD	denotes	1992
T1511	5184-5185	:	denotes	;
T1512	5186-5192	NNP	denotes	Miller
T1513	5193-5195	FW	denotes	et
T1514	5196-5199	FW	denotes	al.
T1515	5200-5204	CD	denotes	1993
T1516	5204-5205	-RRB-	denotes	)
T1517	5205-5206	.	denotes	.
T1518	5206-5420	sentence	denotes	Secreted by dermal papilla cells within each hair follicle (Millar et al. 1995), Agouti protein causes melanocytes in that follicle to switch from the production of brown/black eumelanin to red/yellow pheomelanin.
T1519	5207-5215	VBN	denotes	Secreted
T1520	5303-5309	VBZ	denotes	causes
T1521	5216-5218	IN	denotes	by
T1522	5219-5225	JJ	denotes	dermal
T1523	5234-5239	NNS	denotes	cells
T1524	5226-5233	NN	denotes	papilla
T1525	5240-5246	IN	denotes	within
T1526	5247-5251	DT	denotes	each
T1527	5257-5265	NN	denotes	follicle
T1528	5252-5256	NN	denotes	hair
T1529	5266-5267	-LRB-	denotes	(
T1530	5267-5273	NNP	denotes	Millar
T1531	5274-5276	FW	denotes	et
T1532	5277-5280	FW	denotes	al.
T1533	5281-5285	CD	denotes	1995
T1534	5285-5286	-RRB-	denotes	)
T1535	5286-5288	,	denotes	,
T1536	5288-5294	NN	denotes	Agouti
T1537	5295-5302	NN	denotes	protein
T1538	5310-5321	NNS	denotes	melanocytes
T1539	5342-5348	VB	denotes	switch
T1540	5322-5324	IN	denotes	in
T1541	5325-5329	DT	denotes	that
T1542	5330-5338	NN	denotes	follicle
T1543	5339-5341	TO	denotes	to
T1544	5349-5353	IN	denotes	from
T1545	5354-5357	DT	denotes	the
T1546	5358-5368	NN	denotes	production
T1547	5369-5371	IN	denotes	of
T1548	5372-5377	JJ	denotes	brown
T1549	5378-5383	JJ	denotes	black
T1550	5377-5378	HYPH	denotes	/
T1551	5384-5393	NN	denotes	eumelanin
T1552	5394-5396	IN	denotes	to
T1553	5397-5400	JJ	denotes	red
T1554	5401-5407	JJ	denotes	yellow
T1555	5400-5401	HYPH	denotes	/
T1556	5408-5419	NN	denotes	pheomelanin
T1557	5419-5420	.	denotes	.
T1558	5420-5889	sentence	denotes	Agouti protein has a short radius of action (Silvers and Russel 1955) and can be switched on and off during a single hair cycle (Bultman et al. 1992, 1994; Miller et al. 1993; Vrieling et al. 1994); thus, its regulated expression is thought to be responsible for the cream-colored or yellow ventral surface of mice carrying the black-and-tan (at) allele and for the yellow markings around the feet, ears, or head, i.e., tan points or head spots, of certain dog breeds.
T1559	5421-5427	NN	denotes	Agouti
T1560	5428-5435	NN	denotes	protein
T1561	5436-5439	VBZ	denotes	has
T1562	5654-5661	VBN	denotes	thought
T1563	5440-5441	DT	denotes	a
T1564	5448-5454	NN	denotes	radius
T1565	5442-5447	JJ	denotes	short
T1566	5455-5457	IN	denotes	of
T1567	5458-5464	NN	denotes	action
T1568	5465-5466	-LRB-	denotes	(
T1569	5466-5473	NNP	denotes	Silvers
T1570	5474-5477	CC	denotes	and
T1571	5478-5484	NNP	denotes	Russel
T1572	5485-5489	CD	denotes	1955
T1573	5489-5490	-RRB-	denotes	)
T1574	5491-5494	CC	denotes	and
T1575	5495-5498	MD	denotes	can
T1576	5502-5510	VBN	denotes	switched
T1577	5499-5501	VB	denotes	be
T1578	5511-5513	RP	denotes	on
T1579	5514-5517	CC	denotes	and
T1580	5518-5521	RP	denotes	off
T1581	5522-5528	IN	denotes	during
T1582	5529-5530	DT	denotes	a
T1583	5543-5548	NN	denotes	cycle
T1584	5531-5537	JJ	denotes	single
T1585	5538-5542	NN	denotes	hair
T1586	5549-5550	-LRB-	denotes	(
T1587	5550-5557	NNP	denotes	Bultman
T1588	5558-5560	FW	denotes	et
T1589	5561-5564	FW	denotes	al.
T1590	5565-5569	CD	denotes	1992
T1591	5569-5571	,	denotes	,
T1592	5571-5575	CD	denotes	1994
T1593	5575-5576	:	denotes	;
T1594	5577-5583	NNP	denotes	Miller
T1595	5584-5586	FW	denotes	et
T1596	5587-5590	FW	denotes	al.
T1597	5591-5595	CD	denotes	1993
T1598	5595-5596	:	denotes	;
T1599	5597-5605	NNP	denotes	Vrieling
T1600	5606-5608	FW	denotes	et
T1601	5609-5612	FW	denotes	al.
T1602	5613-5617	CD	denotes	1994
T1603	5617-5618	-RRB-	denotes	)
T1604	5618-5619	:	denotes	;
T1605	5620-5624	RB	denotes	thus
T1606	5624-5626	,	denotes	,
T1607	5626-5629	PRP$	denotes	its
T1608	5640-5650	NN	denotes	expression
T1609	5630-5639	VBN	denotes	regulated
T1610	5651-5653	VBZ	denotes	is
T1611	5662-5664	TO	denotes	to
T1612	5665-5667	VB	denotes	be
T1613	5668-5679	JJ	denotes	responsible
T1614	5680-5683	IN	denotes	for
T1615	5684-5687	DT	denotes	the
T1616	5720-5727	NN	denotes	surface
T1617	5688-5693	NN	denotes	cream
T1618	5694-5701	VBN	denotes	colored
T1619	5693-5694	HYPH	denotes	-
T1620	5702-5704	CC	denotes	or
T1621	5705-5711	JJ	denotes	yellow
T1622	5712-5719	JJ	denotes	ventral
T1623	5728-5730	IN	denotes	of
T1624	5731-5735	NNS	denotes	mice
T1625	5736-5744	VBG	denotes	carrying
T1626	5745-5748	DT	denotes	the
T1627	5768-5774	NN	denotes	allele
T1628	5749-5754	JJ	denotes	black
T1629	5754-5755	HYPH	denotes	-
T1630	5755-5758	CC	denotes	and
T1631	5758-5759	HYPH	denotes	-
T1632	5759-5762	JJ	denotes	tan
T1633	5763-5764	-LRB-	denotes	(
T1634	5764-5766	NN	denotes	at
T1635	5766-5767	-RRB-	denotes	)
T1636	5775-5778	CC	denotes	and
T1637	5779-5782	IN	denotes	for
T1638	5783-5786	DT	denotes	the
T1639	5794-5802	NNS	denotes	markings
T1640	5787-5793	JJ	denotes	yellow
T1641	5803-5809	IN	denotes	around
T1642	5810-5813	DT	denotes	the
T1643	5814-5818	NNS	denotes	feet
T1644	5818-5820	,	denotes	,
T1645	5820-5824	NNS	denotes	ears
T1646	5824-5826	,	denotes	,
T1647	5826-5828	CC	denotes	or
T1648	5829-5833	NN	denotes	head
T1649	5833-5835	,	denotes	,
T1650	5835-5839	FW	denotes	i.e.
T1651	5845-5851	NNS	denotes	points
T1652	5839-5841	,	denotes	,
T1653	5841-5844	JJ	denotes	tan
T1654	5852-5854	CC	denotes	or
T1655	5855-5859	NN	denotes	head
T1656	5860-5865	NNS	denotes	spots
T1657	5865-5867	,	denotes	,
T1658	5867-5869	IN	denotes	of
T1659	5870-5877	JJ	denotes	certain
T1660	5882-5888	NNS	denotes	breeds
T1661	5878-5881	NN	denotes	dog
T1662	5888-5889	.	denotes	.
T1663	5889-6090	sentence	denotes	In laboratory mice, previous studies from our group and others identified two predominant Agouti mRNA isoforms that differ by virtue of their transcriptional initiation site and 5′ untranslated exons.
T1664	5890-5892	IN	denotes	In
T1665	5953-5963	VBD	denotes	identified
T1666	5893-5903	NN	denotes	laboratory
T1667	5904-5908	NNS	denotes	mice
T1668	5908-5910	,	denotes	,
T1669	5910-5918	JJ	denotes	previous
T1670	5919-5926	NNS	denotes	studies
T1671	5927-5931	IN	denotes	from
T1672	5932-5935	PRP$	denotes	our
T1673	5936-5941	NN	denotes	group
T1674	5942-5945	CC	denotes	and
T1675	5946-5952	NNS	denotes	others
T1676	5964-5967	CD	denotes	two
T1677	5992-6000	NNS	denotes	isoforms
T1678	5968-5979	JJ	denotes	predominant
T1679	5980-5986	NN	denotes	Agouti
T1680	5987-5991	NN	denotes	mRNA
T1681	6001-6005	WDT	denotes	that
T1682	6006-6012	VBP	denotes	differ
T1683	6013-6015	IN	denotes	by
T1684	6016-6022	NN	denotes	virtue
T1685	6023-6025	IN	denotes	of
T1686	6026-6031	PRP$	denotes	their
T1687	6059-6063	NN	denotes	site
T1688	6032-6047	JJ	denotes	transcriptional
T1689	6048-6058	NN	denotes	initiation
T1690	6064-6067	CC	denotes	and
T1691	6068-6069	CD	denotes	5
T1692	6084-6089	NNS	denotes	exons
T1693	6069-6070	SYM	denotes	′
T1694	6071-6083	JJ	denotes	untranslated
T1695	6089-6090	.	denotes	.
T1696	6090-6382	sentence	denotes	A “hair cycle-specific” transcript is expressed in both dorsal and ventral skin for 2–3 days during early hair growth, while a “ventral-specific” transcript is expressed throughout the entire period of active hair growth, but only in ventral skin (Bultman et al. 1994; Vrieling et al. 1994).
T1697	6091-6092	DT	denotes	A
T1698	6115-6125	NN	denotes	transcript
T1699	6093-6094	``	denotes	“
T1700	6094-6098	NN	denotes	hair
T1701	6099-6104	NN	denotes	cycle
T1702	6105-6113	JJ	denotes	specific
T1703	6104-6105	HYPH	denotes	-
T1704	6113-6114	''	denotes	”
T1705	6129-6138	VBN	denotes	expressed
T1706	6126-6128	VBZ	denotes	is
T1707	6139-6141	IN	denotes	in
T1708	6142-6146	CC	denotes	both
T1709	6147-6153	JJ	denotes	dorsal
T1710	6166-6170	NN	denotes	skin
T1711	6154-6157	CC	denotes	and
T1712	6158-6165	JJ	denotes	ventral
T1713	6171-6174	IN	denotes	for
T1714	6175-6176	CD	denotes	2
T1715	6177-6178	CD	denotes	3
T1716	6176-6177	HYPH	denotes	–
T1717	6179-6183	NNS	denotes	days
T1718	6184-6190	IN	denotes	during
T1719	6191-6196	JJ	denotes	early
T1720	6202-6208	NN	denotes	growth
T1721	6197-6201	NN	denotes	hair
T1722	6208-6210	,	denotes	,
T1723	6210-6215	IN	denotes	while
T1724	6251-6260	VBN	denotes	expressed
T1725	6216-6217	DT	denotes	a
T1726	6237-6247	NN	denotes	transcript
T1727	6218-6219	``	denotes	“
T1728	6219-6226	JJ	denotes	ventral
T1729	6227-6235	JJ	denotes	specific
T1730	6226-6227	HYPH	denotes	-
T1731	6235-6236	''	denotes	”
T1732	6248-6250	VBZ	denotes	is
T1733	6261-6271	IN	denotes	throughout
T1734	6272-6275	DT	denotes	the
T1735	6283-6289	NN	denotes	period
T1736	6276-6282	JJ	denotes	entire
T1737	6290-6292	IN	denotes	of
T1738	6293-6299	JJ	denotes	active
T1739	6305-6311	NN	denotes	growth
T1740	6300-6304	NN	denotes	hair
T1741	6311-6313	,	denotes	,
T1742	6313-6316	CC	denotes	but
T1743	6317-6321	RB	denotes	only
T1744	6322-6324	IN	denotes	in
T1745	6325-6332	JJ	denotes	ventral
T1746	6333-6337	NN	denotes	skin
T1747	6338-6339	-LRB-	denotes	(
T1748	6339-6346	NNP	denotes	Bultman
T1749	6347-6349	FW	denotes	et
T1750	6350-6353	FW	denotes	al.
T1751	6354-6358	CD	denotes	1994
T1752	6358-6359	:	denotes	;
T1753	6360-6368	NNP	denotes	Vrieling
T1754	6369-6371	FW	denotes	et
T1755	6372-6375	FW	denotes	al.
T1756	6376-6380	CD	denotes	1994
T1757	6380-6381	-RRB-	denotes	)
T1758	6381-6382	.	denotes	.
T1759	6382-6689	sentence	denotes	Animals carrying the at allele express only the ventral-specific Agouti transcript (Bultman et al. 1994; Vrieling et al. 1994) and have black dorsal hairs and cream-colored to yellow ventral hairs, with a sharp boundary at the level of the limb–body wall articulations and in the middle of the whisker pad.
T1760	6383-6390	NNS	denotes	Animals
T1761	6414-6421	VBP	denotes	express
T1762	6391-6399	VBG	denotes	carrying
T1763	6400-6403	DT	denotes	the
T1764	6407-6413	NN	denotes	allele
T1765	6404-6406	NN	denotes	at
T1766	6422-6426	RB	denotes	only
T1767	6455-6465	NN	denotes	transcript
T1768	6427-6430	DT	denotes	the
T1769	6431-6438	JJ	denotes	ventral
T1770	6439-6447	JJ	denotes	specific
T1771	6438-6439	HYPH	denotes	-
T1772	6448-6454	NN	denotes	Agouti
T1773	6466-6467	-LRB-	denotes	(
T1774	6467-6474	NNP	denotes	Bultman
T1775	6475-6477	FW	denotes	et
T1776	6478-6481	FW	denotes	al.
T1777	6482-6486	CD	denotes	1994
T1778	6486-6487	:	denotes	;
T1779	6488-6496	NNP	denotes	Vrieling
T1780	6497-6499	FW	denotes	et
T1781	6500-6503	FW	denotes	al.
T1782	6504-6508	CD	denotes	1994
T1783	6508-6509	-RRB-	denotes	)
T1784	6510-6513	CC	denotes	and
T1785	6514-6518	VBP	denotes	have
T1786	6519-6524	JJ	denotes	black
T1787	6532-6537	NNS	denotes	hairs
T1788	6525-6531	JJ	denotes	dorsal
T1789	6538-6541	CC	denotes	and
T1790	6542-6547	NN	denotes	cream
T1791	6548-6555	VBN	denotes	colored
T1792	6547-6548	HYPH	denotes	-
T1793	6574-6579	NNS	denotes	hairs
T1794	6556-6558	IN	denotes	to
T1795	6559-6565	JJ	denotes	yellow
T1796	6566-6573	JJ	denotes	ventral
T1797	6579-6581	,	denotes	,
T1798	6581-6585	IN	denotes	with
T1799	6586-6587	DT	denotes	a
T1800	6594-6602	NN	denotes	boundary
T1801	6588-6593	JJ	denotes	sharp
T1802	6603-6605	IN	denotes	at
T1803	6606-6609	DT	denotes	the
T1804	6610-6615	NN	denotes	level
T1805	6616-6618	IN	denotes	of
T1806	6619-6622	DT	denotes	the
T1807	6638-6651	NNS	denotes	articulations
T1808	6623-6627	NN	denotes	limb
T1809	6627-6628	HYPH	denotes	–
T1810	6628-6632	NN	denotes	body
T1811	6633-6637	NN	denotes	wall
T1812	6652-6655	CC	denotes	and
T1813	6656-6658	IN	denotes	in
T1814	6659-6662	DT	denotes	the
T1815	6663-6669	NN	denotes	middle
T1816	6670-6672	IN	denotes	of
T1817	6673-6676	DT	denotes	the
T1818	6685-6688	NN	denotes	pad
T1819	6677-6684	NN	denotes	whisker
T1820	6688-6689	.	denotes	.
T1821	6689-6877	sentence	denotes	Ventral-specific Agouti isoforms are also expressed in developing skin from embryonic day 10.5 (E10.5) and beyond and may play a role in pigment cell differentiation (Millar et al. 1995).
T1822	6690-6697	JJ	denotes	Ventral
T1823	6698-6706	JJ	denotes	specific
T1824	6697-6698	HYPH	denotes	-
T1825	6714-6722	NNS	denotes	isoforms
T1826	6707-6713	NN	denotes	Agouti
T1827	6732-6741	VBN	denotes	expressed
T1828	6723-6726	VBP	denotes	are
T1829	6727-6731	RB	denotes	also
T1830	6742-6744	IN	denotes	in
T1831	6745-6755	VBG	denotes	developing
T1832	6756-6760	NN	denotes	skin
T1833	6761-6765	IN	denotes	from
T1834	6766-6775	JJ	denotes	embryonic
T1835	6776-6779	NN	denotes	day
T1836	6780-6784	CD	denotes	10.5
T1837	6785-6786	-LRB-	denotes	(
T1838	6786-6791	NN	denotes	E10.5
T1839	6791-6792	-RRB-	denotes	)
T1840	6793-6796	CC	denotes	and
T1841	6797-6803	RB	denotes	beyond
T1842	6804-6807	CC	denotes	and
T1843	6808-6811	MD	denotes	may
T1844	6812-6816	VB	denotes	play
T1845	6817-6818	DT	denotes	a
T1846	6819-6823	NN	denotes	role
T1847	6824-6826	IN	denotes	in
T1848	6827-6834	NN	denotes	pigment
T1849	6840-6855	NN	denotes	differentiation
T1850	6835-6839	NN	denotes	cell
T1851	6856-6857	-LRB-	denotes	(
T1852	6857-6863	NNP	denotes	Millar
T1853	6864-6866	FW	denotes	et
T1854	6867-6870	FW	denotes	al.
T1855	6871-6875	CD	denotes	1995
T1856	6875-6876	-RRB-	denotes	)
T1857	6876-6877	.	denotes	.
T1858	6877-7052	sentence	denotes	Thus, regulatory elements for ventral-specific Agouti isoforms are responsive to dorsoventral positional cues established in the embryo and whose effects persist after birth.
T1859	6878-6882	RB	denotes	Thus
T1860	6941-6944	VBP	denotes	are
T1861	6882-6884	,	denotes	,
T1862	6884-6894	JJ	denotes	regulatory
T1863	6895-6903	NNS	denotes	elements
T1864	6904-6907	IN	denotes	for
T1865	6908-6915	JJ	denotes	ventral
T1866	6916-6924	JJ	denotes	specific
T1867	6915-6916	HYPH	denotes	-
T1868	6932-6940	NNS	denotes	isoforms
T1869	6925-6931	NN	denotes	Agouti
T1870	6945-6955	JJ	denotes	responsive
T1871	6956-6958	IN	denotes	to
T1872	6959-6971	JJ	denotes	dorsoventral
T1873	6983-6987	NNS	denotes	cues
T1874	6972-6982	JJ	denotes	positional
T1875	6988-6999	VBN	denotes	established
T1876	7000-7002	IN	denotes	in
T1877	7003-7006	DT	denotes	the
T1878	7007-7013	NN	denotes	embryo
T1879	7014-7017	CC	denotes	and
T1880	7018-7023	WP$	denotes	whose
T1881	7024-7031	NNS	denotes	effects
T1882	7032-7039	VBP	denotes	persist
T1883	7040-7045	IN	denotes	after
T1884	7046-7051	NN	denotes	birth
T1885	7051-7052	.	denotes	.
T1886	7052-7374	sentence	denotes	The boundary between dorsal and ventral color compartments in at/at mice bears superficial resemblance to dorsoventral boundaries apparent for many other mammals, but morphogenetic differences between dorsal and ventral skin seem likely to include more elements than the type of pigment made by hair follicle melanocytes.
T1887	7053-7056	DT	denotes	The
T1888	7057-7065	NN	denotes	boundary
T1889	7126-7131	VBZ	denotes	bears
T1890	7066-7073	IN	denotes	between
T1891	7074-7080	JJ	denotes	dorsal
T1892	7099-7111	NNS	denotes	compartments
T1893	7081-7084	CC	denotes	and
T1894	7085-7092	JJ	denotes	ventral
T1895	7093-7098	NN	denotes	color
T1896	7112-7114	IN	denotes	in
T1897	7115-7117	NN	denotes	at
T1898	7118-7120	NN	denotes	at
T1899	7117-7118	HYPH	denotes	/
T1900	7121-7125	NNS	denotes	mice
T1901	7132-7143	JJ	denotes	superficial
T1902	7144-7155	NN	denotes	resemblance
T1903	7156-7158	IN	denotes	to
T1904	7159-7171	JJ	denotes	dorsoventral
T1905	7172-7182	NNS	denotes	boundaries
T1906	7183-7191	JJ	denotes	apparent
T1907	7192-7195	IN	denotes	for
T1908	7196-7200	JJ	denotes	many
T1909	7207-7214	NNS	denotes	mammals
T1910	7201-7206	JJ	denotes	other
T1911	7214-7216	,	denotes	,
T1912	7216-7219	CC	denotes	but
T1913	7220-7233	JJ	denotes	morphogenetic
T1914	7234-7245	NNS	denotes	differences
T1915	7278-7282	VBP	denotes	seem
T1916	7246-7253	IN	denotes	between
T1917	7254-7260	JJ	denotes	dorsal
T1918	7273-7277	NN	denotes	skin
T1919	7261-7264	CC	denotes	and
T1920	7265-7272	JJ	denotes	ventral
T1921	7283-7289	RB	denotes	likely
T1922	7290-7292	TO	denotes	to
T1923	7293-7300	VB	denotes	include
T1924	7301-7305	JJR	denotes	more
T1925	7306-7314	NNS	denotes	elements
T1926	7315-7319	IN	denotes	than
T1927	7320-7323	DT	denotes	the
T1928	7324-7328	NN	denotes	type
T1929	7329-7331	IN	denotes	of
T1930	7332-7339	NN	denotes	pigment
T1931	7340-7344	VBN	denotes	made
T1932	7345-7347	IN	denotes	by
T1933	7348-7352	NN	denotes	hair
T1934	7353-7361	NN	denotes	follicle
T1935	7362-7373	NNS	denotes	melanocytes
T1936	7373-7374	.	denotes	.
T1937	7374-7792	sentence	denotes	In particular, dermis of the flank has at least two distinct origins: dermatomal derivatives of somites and loose mesenchyme derived from the lateral plate mesoderm (Mauger 1972; Christ et al. 1983; Olivera-Martinez et al. 2000; Nowicki et al. 2003); these lineages are established early in development and could, in principle, set up compartments whose identity contributes to dorsoventral differences in adult skin.
T1938	7375-7377	IN	denotes	In
T1939	7410-7413	VBZ	denotes	has
T1940	7378-7388	JJ	denotes	particular
T1941	7388-7390	,	denotes	,
T1942	7390-7396	NN	denotes	dermis
T1943	7397-7399	IN	denotes	of
T1944	7400-7403	DT	denotes	the
T1945	7404-7409	NN	denotes	flank
T1946	7645-7656	VBN	denotes	established
T1947	7414-7416	RB	denotes	at
T1948	7423-7426	CD	denotes	two
T1949	7417-7422	RBS	denotes	least
T1950	7436-7443	NNS	denotes	origins
T1951	7427-7435	JJ	denotes	distinct
T1952	7443-7445	:	denotes	:
T1953	7445-7455	JJ	denotes	dermatomal
T1954	7456-7467	NNS	denotes	derivatives
T1955	7468-7470	IN	denotes	of
T1956	7471-7478	NNS	denotes	somites
T1957	7479-7482	CC	denotes	and
T1958	7483-7488	JJ	denotes	loose
T1959	7489-7499	NN	denotes	mesenchyme
T1960	7500-7507	VBN	denotes	derived
T1961	7508-7512	IN	denotes	from
T1962	7513-7516	DT	denotes	the
T1963	7531-7539	NN	denotes	mesoderm
T1964	7517-7524	JJ	denotes	lateral
T1965	7525-7530	NN	denotes	plate
T1966	7540-7541	-LRB-	denotes	(
T1967	7541-7547	NNP	denotes	Mauger
T1968	7548-7552	CD	denotes	1972
T1969	7552-7553	:	denotes	;
T1970	7554-7560	NNP	denotes	Christ
T1971	7561-7563	FW	denotes	et
T1972	7564-7567	FW	denotes	al.
T1973	7568-7572	CD	denotes	1983
T1974	7572-7573	:	denotes	;
T1975	7574-7581	NNP	denotes	Olivera
T1976	7581-7582	HYPH	denotes	-
T1977	7582-7590	NNP	denotes	Martinez
T1978	7591-7593	FW	denotes	et
T1979	7594-7597	FW	denotes	al.
T1980	7598-7602	CD	denotes	2000
T1981	7602-7603	:	denotes	;
T1982	7604-7611	NNP	denotes	Nowicki
T1983	7612-7614	FW	denotes	et
T1984	7615-7618	FW	denotes	al.
T1985	7619-7623	CD	denotes	2003
T1986	7623-7624	-RRB-	denotes	)
T1987	7624-7625	:	denotes	;
T1988	7626-7631	DT	denotes	these
T1989	7632-7640	NNS	denotes	lineages
T1990	7641-7644	VBP	denotes	are
T1991	7657-7662	RB	denotes	early
T1992	7663-7665	IN	denotes	in
T1993	7666-7677	NN	denotes	development
T1994	7678-7681	CC	denotes	and
T1995	7682-7687	MD	denotes	could
T1996	7703-7706	VBN	denotes	set
T1997	7687-7689	,	denotes	,
T1998	7689-7691	IN	denotes	in
T1999	7692-7701	JJ	denotes	principle
T2000	7701-7703	,	denotes	,
T2001	7707-7709	RP	denotes	up
T2002	7710-7722	NNS	denotes	compartments
T2003	7723-7728	WP$	denotes	whose
T2004	7729-7737	NN	denotes	identity
T2005	7738-7749	VBZ	denotes	contributes
T2006	7750-7752	IN	denotes	to
T2007	7753-7765	JJ	denotes	dorsoventral
T2008	7766-7777	NNS	denotes	differences
T2009	7778-7780	IN	denotes	in
T2010	7781-7786	JJ	denotes	adult
T2011	7787-7791	NN	denotes	skin
T2012	7791-7792	.	denotes	.
T2013	7792-8191	sentence	denotes	To better understand the mechanisms that give rise to differences between dorsal and ventral skin and to the boundary between them, we have determined how several morphologic characteristics vary along the dorsoventral axis of the mouse and how these characteristics correspond to ventral-specific Agouti expression and the lineage boundary that distinguishes somite from lateral plate derivatives.
T2014	7793-7795	TO	denotes	To
T2015	7803-7813	VB	denotes	understand
T2016	7796-7802	RBR	denotes	better
T2017	7933-7943	VBN	denotes	determined
T2018	7814-7817	DT	denotes	the
T2019	7818-7828	NNS	denotes	mechanisms
T2020	7829-7833	WDT	denotes	that
T2021	7834-7838	VBP	denotes	give
T2022	7839-7843	NN	denotes	rise
T2023	7844-7846	IN	denotes	to
T2024	7847-7858	NNS	denotes	differences
T2025	7859-7866	IN	denotes	between
T2026	7867-7873	JJ	denotes	dorsal
T2027	7886-7890	NN	denotes	skin
T2028	7874-7877	CC	denotes	and
T2029	7878-7885	JJ	denotes	ventral
T2030	7891-7894	CC	denotes	and
T2031	7895-7897	IN	denotes	to
T2032	7898-7901	DT	denotes	the
T2033	7902-7910	NN	denotes	boundary
T2034	7911-7918	IN	denotes	between
T2035	7919-7923	PRP	denotes	them
T2036	7923-7925	,	denotes	,
T2037	7925-7927	PRP	denotes	we
T2038	7928-7932	VBP	denotes	have
T2039	7944-7947	WRB	denotes	how
T2040	7984-7988	VBP	denotes	vary
T2041	7948-7955	JJ	denotes	several
T2042	7968-7983	NNS	denotes	characteristics
T2043	7956-7967	JJ	denotes	morphologic
T2044	7989-7994	IN	denotes	along
T2045	7995-7998	DT	denotes	the
T2046	8012-8016	NN	denotes	axis
T2047	7999-8011	JJ	denotes	dorsoventral
T2048	8017-8019	IN	denotes	of
T2049	8020-8023	DT	denotes	the
T2050	8024-8029	NN	denotes	mouse
T2051	8030-8033	CC	denotes	and
T2052	8034-8037	WRB	denotes	how
T2053	8060-8070	VBP	denotes	correspond
T2054	8038-8043	DT	denotes	these
T2055	8044-8059	NNS	denotes	characteristics
T2056	8071-8073	IN	denotes	to
T2057	8074-8081	JJ	denotes	ventral
T2058	8082-8090	JJ	denotes	specific
T2059	8081-8082	HYPH	denotes	-
T2060	8098-8108	NN	denotes	expression
T2061	8091-8097	NN	denotes	Agouti
T2062	8109-8112	CC	denotes	and
T2063	8113-8116	DT	denotes	the
T2064	8125-8133	NN	denotes	boundary
T2065	8117-8124	NN	denotes	lineage
T2066	8134-8138	WDT	denotes	that
T2067	8139-8152	VBZ	denotes	distinguishes
T2068	8153-8159	NN	denotes	somite
T2069	8160-8164	IN	denotes	from
T2070	8165-8172	JJ	denotes	lateral
T2071	8179-8190	NNS	denotes	derivatives
T2072	8173-8178	NN	denotes	plate
T2073	8190-8191	.	denotes	.
T2074	8191-8496	sentence	denotes	Our results indicate that the apparent uniformity of the dorsoventral boundary represents the sum of independent mechanisms that affect melanocyte density and/or differentiation, pigment-type synthesis, and hair length; surprisingly, none of these coincide with the somite–lateral plate lineage boundary.
T2075	8192-8195	PRP$	denotes	Our
T2076	8196-8203	NNS	denotes	results
T2077	8204-8212	VBP	denotes	indicate
T2078	8440-8448	VBP	denotes	coincide
T2079	8213-8217	IN	denotes	that
T2080	8271-8281	VBZ	denotes	represents
T2081	8218-8221	DT	denotes	the
T2082	8231-8241	NN	denotes	uniformity
T2083	8222-8230	JJ	denotes	apparent
T2084	8242-8244	IN	denotes	of
T2085	8245-8248	DT	denotes	the
T2086	8262-8270	NN	denotes	boundary
T2087	8249-8261	JJ	denotes	dorsoventral
T2088	8282-8285	DT	denotes	the
T2089	8286-8289	NN	denotes	sum
T2090	8290-8292	IN	denotes	of
T2091	8293-8304	JJ	denotes	independent
T2092	8305-8315	NNS	denotes	mechanisms
T2093	8316-8320	WDT	denotes	that
T2094	8321-8327	VBP	denotes	affect
T2095	8328-8338	NN	denotes	melanocyte
T2096	8339-8346	NN	denotes	density
T2097	8347-8350	CC	denotes	and
T2098	8350-8351	HYPH	denotes	/
T2099	8351-8353	CC	denotes	or
T2100	8354-8369	NN	denotes	differentiation
T2101	8369-8371	,	denotes	,
T2102	8371-8378	NN	denotes	pigment
T2103	8379-8383	NN	denotes	type
T2104	8378-8379	HYPH	denotes	-
T2105	8384-8393	NN	denotes	synthesis
T2106	8393-8395	,	denotes	,
T2107	8395-8398	CC	denotes	and
T2108	8399-8403	NN	denotes	hair
T2109	8404-8410	NN	denotes	length
T2110	8410-8411	:	denotes	;
T2111	8412-8424	RB	denotes	surprisingly
T2112	8424-8426	,	denotes	,
T2113	8426-8430	NN	denotes	none
T2114	8431-8433	IN	denotes	of
T2115	8434-8439	DT	denotes	these
T2116	8449-8453	IN	denotes	with
T2117	8454-8457	DT	denotes	the
T2118	8487-8495	NN	denotes	boundary
T2119	8458-8464	NN	denotes	somite
T2120	8465-8472	JJ	denotes	lateral
T2121	8464-8465	HYPH	denotes	–
T2122	8473-8478	NN	denotes	plate
T2123	8479-8486	NN	denotes	lineage
T2124	8495-8496	.	denotes	.
T2125	8496-8703	sentence	denotes	We also make use of a classical mouse mutation, droopy ear (Curry 1959), that produces a dorsal-to-ventral transformation of flank coat color by allowing expansion of the ventral-specific Agouti transcript.
T2126	8497-8499	PRP	denotes	We
T2127	8505-8509	VBP	denotes	make
T2128	8500-8504	RB	denotes	also
T2129	8510-8513	NN	denotes	use
T2130	8514-8516	IN	denotes	of
T2131	8517-8518	DT	denotes	a
T2132	8535-8543	NN	denotes	mutation
T2133	8519-8528	JJ	denotes	classical
T2134	8529-8534	NN	denotes	mouse
T2135	8543-8545	,	denotes	,
T2136	8545-8551	JJ	denotes	droopy
T2137	8552-8555	NN	denotes	ear
T2138	8556-8557	-LRB-	denotes	(
T2139	8557-8562	NNP	denotes	Curry
T2140	8563-8567	CD	denotes	1959
T2141	8567-8568	-RRB-	denotes	)
T2142	8568-8570	,	denotes	,
T2143	8570-8574	WDT	denotes	that
T2144	8575-8583	VBZ	denotes	produces
T2145	8584-8585	DT	denotes	a
T2146	8604-8618	NN	denotes	transformation
T2147	8586-8592	JJ	denotes	dorsal
T2148	8592-8593	HYPH	denotes	-
T2149	8593-8595	IN	denotes	to
T2150	8595-8596	HYPH	denotes	-
T2151	8596-8603	JJ	denotes	ventral
T2152	8619-8621	IN	denotes	of
T2153	8622-8627	NN	denotes	flank
T2154	8633-8638	NN	denotes	color
T2155	8628-8632	NN	denotes	coat
T2156	8639-8641	IN	denotes	by
T2157	8642-8650	VBG	denotes	allowing
T2158	8651-8660	NN	denotes	expansion
T2159	8661-8663	IN	denotes	of
T2160	8664-8667	DT	denotes	the
T2161	8692-8702	NN	denotes	transcript
T2162	8668-8675	JJ	denotes	ventral
T2163	8676-8684	JJ	denotes	specific
T2164	8675-8676	HYPH	denotes	-
T2165	8685-8691	NN	denotes	Agouti
T2166	8702-8703	.	denotes	.
T2167	8703-8969	sentence	denotes	By positional cloning and gene targeting, we identify an allele of droopy ear, deH, as a loss of function for Tbx15, which encodes a T-box transcription factor expressed in a dynamic and spatially restricted manner in the developing skin and musculoskeletal system.
T2168	8704-8706	IN	denotes	By
T2169	8749-8757	VBP	denotes	identify
T2170	8707-8717	JJ	denotes	positional
T2171	8718-8725	NN	denotes	cloning
T2172	8726-8729	CC	denotes	and
T2173	8730-8734	NN	denotes	gene
T2174	8735-8744	NN	denotes	targeting
T2175	8744-8746	,	denotes	,
T2176	8746-8748	PRP	denotes	we
T2177	8758-8760	DT	denotes	an
T2178	8761-8767	NN	denotes	allele
T2179	8768-8770	IN	denotes	of
T2180	8771-8777	JJ	denotes	droopy
T2181	8778-8781	NN	denotes	ear
T2182	8781-8783	,	denotes	,
T2183	8783-8786	NN	denotes	deH
T2184	8786-8788	,	denotes	,
T2185	8788-8790	IN	denotes	as
T2186	8791-8792	DT	denotes	a
T2187	8793-8797	NN	denotes	loss
T2188	8798-8800	IN	denotes	of
T2189	8801-8809	NN	denotes	function
T2190	8810-8813	IN	denotes	for
T2191	8814-8819	NN	denotes	Tbx15
T2192	8819-8821	,	denotes	,
T2193	8821-8826	WDT	denotes	which
T2194	8827-8834	VBZ	denotes	encodes
T2195	8835-8836	DT	denotes	a
T2196	8857-8863	NN	denotes	factor
T2197	8837-8838	NN	denotes	T
T2198	8839-8842	NN	denotes	box
T2199	8838-8839	HYPH	denotes	-
T2200	8843-8856	NN	denotes	transcription
T2201	8864-8873	VBN	denotes	expressed
T2202	8874-8876	IN	denotes	in
T2220	8980-8990	NN	denotes	expression
T2221	8991-8994	CC	denotes	and
T2222	8995-9010	NN	denotes	transplantation
T2223	9019-9026	VBP	denotes	suggest
T2224	9027-9031	IN	denotes	that
T2225	9041-9049	VBN	denotes	required
T2226	9032-9037	NN	denotes	Tbx15
T2227	9038-9040	VBZ	denotes	is
T2228	9050-9052	TO	denotes	to
T2229	9053-9062	VB	denotes	establish
T2230	9063-9070	JJ	denotes	certain
T2231	9071-9086	NNS	denotes	characteristics
T2232	9087-9089	IN	denotes	of
T2233	9090-9096	JJ	denotes	dorsal
T2234	9097-9107	NN	denotes	patterning
T2235	9108-9110	IN	denotes	in
T2236	9111-9122	JJ	denotes	mesenchymal
T2237	9123-9128	NNS	denotes	cells
T2238	9129-9131	IN	denotes	of
T2239	9132-9135	DT	denotes	the
T2240	9147-9152	NN	denotes	flank
T2241	9136-9146	VBG	denotes	developing
T2242	9152-9153	.	denotes	.
T2243	9153-9384	sentence	denotes	These results identify a previously unappreciated aspect of dorsoventral patterning that is widely represented in furred mammals and provide insight into the mechanisms that underlie region-specific differences in body morphology.
T2244	9154-9159	DT	denotes	These
T2245	9160-9167	NNS	denotes	results
T2246	9168-9176	VBP	denotes	identify
T2247	9177-9178	DT	denotes	a
T2248	9204-9210	NN	denotes	aspect
T2249	9179-9189	RB	denotes	previously
T2250	9190-9203	JJ	denotes	unappreciated
T2251	9211-9213	IN	denotes	of
T2252	9214-9226	JJ	denotes	dorsoventral
T2253	9227-9237	NN	denotes	patterning
T2254	9238-9242	WDT	denotes	that
T2255	9253-9264	VBN	denotes	represented
T2256	9243-9245	VBZ	denotes	is
T2257	9246-9252	RB	denotes	widely
T2258	9265-9267	IN	denotes	in
T2259	9268-9274	JJ	denotes	furred
T2260	9275-9282	NNS	denotes	mammals
T2261	9283-9286	CC	denotes	and
T2262	9287-9294	VBP	denotes	provide
T2263	9295-9302	NN	denotes	insight
T2264	9303-9307	IN	denotes	into
T2265	9308-9311	DT	denotes	the
T2266	9312-9322	NNS	denotes	mechanisms
T2267	9323-9327	WDT	denotes	that
T2268	9328-9336	VBP	denotes	underlie
T2269	9337-9343	NN	denotes	region
T2270	9344-9352	JJ	denotes	specific
T2271	9343-9344	HYPH	denotes	-
T2272	9353-9364	NNS	denotes	differences
T2273	9365-9367	IN	denotes	in
T2274	9368-9372	NN	denotes	body
T2275	9373-9383	NN	denotes	morphology
T2276	9383-9384	.	denotes	.
T2547	9395-9408	JJ	denotes	Morphological
T2548	9409-9419	NNS	denotes	Components
T2549	9420-9422	IN	denotes	of
T2550	9423-9435	JJ	denotes	Dorsoventral
T2551	9441-9452	NNS	denotes	Differences
T2552	9436-9440	NN	denotes	Skin
T2553	9452-9673	sentence	denotes	Besides the obvious change in hair color that frequently distinguishes dorsal from ventral skin, casual observation suggests there are additional differences in hair length, distribution of hair type, and skin thickness.
T2554	9453-9460	IN	denotes	Besides
T2555	9569-9577	VBZ	denotes	suggests
T2556	9461-9464	DT	denotes	the
T2557	9473-9479	NN	denotes	change
T2558	9465-9472	JJ	denotes	obvious
T2559	9480-9482	IN	denotes	in
T2560	9483-9487	NN	denotes	hair
T2561	9488-9493	NN	denotes	color
T2562	9494-9498	WDT	denotes	that
T2563	9510-9523	VBZ	denotes	distinguishes
T2564	9499-9509	RB	denotes	frequently
T2565	9524-9530	JJ	denotes	dorsal
T2566	9531-9535	IN	denotes	from
T2567	9536-9543	JJ	denotes	ventral
T2568	9544-9548	NN	denotes	skin
T2569	9548-9550	,	denotes	,
T2570	9550-9556	JJ	denotes	casual
T2571	9557-9568	NN	denotes	observation
T2572	9578-9583	EX	denotes	there
T2573	9584-9587	VBP	denotes	are
T2574	9588-9598	JJ	denotes	additional
T2575	9599-9610	NNS	denotes	differences
T2576	9611-9613	IN	denotes	in
T2577	9614-9618	NN	denotes	hair
T2578	9619-9625	NN	denotes	length
T2579	9625-9627	,	denotes	,
T2580	9627-9639	NN	denotes	distribution
T2581	9640-9642	IN	denotes	of
T2582	9643-9647	NN	denotes	hair
T2583	9648-9652	NN	denotes	type
T2584	9652-9654	,	denotes	,
T2585	9654-9657	CC	denotes	and
T2586	9658-9662	NN	denotes	skin
T2587	9663-9672	NN	denotes	thickness
T2588	9672-9673	.	denotes	.
T2589	9673-9893	sentence	denotes	Furthermore, dorsoventral differences in pigmentation can represent differences in the number and/or differentiated state of pigment cells, as well as the type of pigment synthesized in response to expression of Agouti.
T2590	9674-9685	RB	denotes	Furthermore
T2591	9732-9741	VB	denotes	represent
T2592	9685-9687	,	denotes	,
T2593	9687-9699	JJ	denotes	dorsoventral
T2594	9700-9711	NNS	denotes	differences
T2595	9712-9714	IN	denotes	in
T2596	9715-9727	NN	denotes	pigmentation
T2597	9728-9731	MD	denotes	can
T2598	9742-9753	NNS	denotes	differences
T2599	9754-9756	IN	denotes	in
T2600	9757-9760	DT	denotes	the
T2601	9761-9767	NN	denotes	number
T2602	9768-9771	CC	denotes	and
T2603	9771-9772	HYPH	denotes	/
T2604	9772-9774	CC	denotes	or
T2605	9775-9789	VBN	denotes	differentiated
T2606	9790-9795	NN	denotes	state
T2607	9796-9798	IN	denotes	of
T2608	9799-9806	NN	denotes	pigment
T2609	9807-9812	NNS	denotes	cells
T2610	9812-9814	,	denotes	,
T2611	9814-9816	RB	denotes	as
T2612	9822-9824	IN	denotes	as
T2613	9817-9821	RB	denotes	well
T2614	9825-9828	DT	denotes	the
T2615	9829-9833	NN	denotes	type
T2616	9834-9836	IN	denotes	of
T2617	9837-9844	NN	denotes	pigment
T2618	9845-9856	VBN	denotes	synthesized
T2619	9857-9859	IN	denotes	in
T2620	9860-9868	NN	denotes	response
T2621	9869-9871	IN	denotes	to
T2622	9872-9882	NN	denotes	expression
T2623	9883-9885	IN	denotes	of
T2624	9886-9892	NN	denotes	Agouti
T2625	9892-9893	.	denotes	.
T2626	9893-10063	sentence	denotes	In particular, ventral hair of at/at animals can vary from cream-colored to reddish-yellow depending on age, strain background, and position along the dorsoventral axis.
T2627	9894-9896	IN	denotes	In
T2628	9943-9947	VB	denotes	vary
T2629	9897-9907	JJ	denotes	particular
T2630	9907-9909	,	denotes	,
T2631	9909-9916	JJ	denotes	ventral
T2632	9917-9921	NN	denotes	hair
T2633	9922-9924	IN	denotes	of
T2634	9925-9927	NN	denotes	at
T2635	9928-9930	NN	denotes	at
T2636	9927-9928	HYPH	denotes	/
T2637	9931-9938	NNS	denotes	animals
T2638	9939-9942	MD	denotes	can
T2639	9948-9952	IN	denotes	from
T2640	9953-9958	NN	denotes	cream
T2641	9959-9966	VBN	denotes	colored
T2642	9958-9959	HYPH	denotes	-
T2643	9967-9969	IN	denotes	to
T2644	9970-9977	JJ	denotes	reddish
T2645	9978-9984	JJ	denotes	yellow
T2646	9977-9978	HYPH	denotes	-
T2647	9985-9994	VBG	denotes	depending
T2648	9995-9997	IN	denotes	on
T2649	9998-10001	NN	denotes	age
T2650	10001-10003	,	denotes	,
T2651	10003-10009	NN	denotes	strain
T2652	10010-10020	NN	denotes	background
T2653	10020-10022	,	denotes	,
T2654	10022-10025	CC	denotes	and
T2655	10026-10034	NN	denotes	position
T2656	10035-10040	IN	denotes	along
T2657	10041-10044	DT	denotes	the
T2658	10058-10062	NN	denotes	axis
T2659	10045-10057	JJ	denotes	dorsoventral
T2660	10062-10063	.	denotes	.
T2661	10063-10185	sentence	denotes	To evaluate the relationship among these components, we compared their features among mice of different Agouti genotypes.
T2662	10064-10066	TO	denotes	To
T2663	10067-10075	VB	denotes	evaluate
T2664	10120-10128	VBD	denotes	compared
T2665	10076-10079	DT	denotes	the
T2666	10080-10092	NN	denotes	relationship
T2667	10093-10098	IN	denotes	among
T2668	10099-10104	DT	denotes	these
T2669	10105-10115	NNS	denotes	components
T2670	10115-10117	,	denotes	,
T2671	10117-10119	PRP	denotes	we
T2672	10129-10134	PRP$	denotes	their
T2673	10135-10143	NNS	denotes	features
T2674	10144-10149	IN	denotes	among
T2675	10150-10154	NNS	denotes	mice
T2676	10155-10157	IN	denotes	of
T2677	10158-10167	JJ	denotes	different
T2678	10175-10184	NNS	denotes	genotypes
T2679	10168-10174	NN	denotes	Agouti
T2680	10184-10185	.	denotes	.
T2681	10185-10467	sentence	denotes	Semiquantitative measurements of hair length plotted as a function of dorsoventral position reveal that the apparent sharp boundary between dorsal and ventral pigment compartments in at/at mice coincides with a more gradual change in both hair color and hair length (Figure 1A–1D).
T2682	10186-10202	JJ	denotes	Semiquantitative
T2683	10203-10215	NNS	denotes	measurements
T2684	10278-10284	VBP	denotes	reveal
T2685	10216-10218	IN	denotes	of
T2686	10219-10223	NN	denotes	hair
T2687	10224-10230	NN	denotes	length
T2688	10231-10238	VBN	denotes	plotted
T2689	10239-10241	IN	denotes	as
T2690	10242-10243	DT	denotes	a
T2691	10244-10252	NN	denotes	function
T2692	10253-10255	IN	denotes	of
T2693	10256-10268	JJ	denotes	dorsoventral
T2694	10269-10277	NN	denotes	position
T2695	10285-10289	IN	denotes	that
T2696	10380-10389	VBZ	denotes	coincides
T2697	10290-10293	DT	denotes	the
T2698	10309-10317	NN	denotes	boundary
T2699	10294-10302	JJ	denotes	apparent
T2700	10303-10308	JJ	denotes	sharp
T2701	10318-10325	IN	denotes	between
T2702	10326-10332	JJ	denotes	dorsal
T2703	10353-10365	NNS	denotes	compartments
T2704	10333-10336	CC	denotes	and
T2705	10337-10344	JJ	denotes	ventral
T2706	10345-10352	NN	denotes	pigment
T2707	10366-10368	IN	denotes	in
T2708	10369-10371	NN	denotes	at
T2709	10372-10374	NN	denotes	at
T2710	10371-10372	HYPH	denotes	/
T2711	10375-10379	NNS	denotes	mice
T2712	10390-10394	IN	denotes	with
T2713	10395-10396	DT	denotes	a
T2714	10410-10416	NN	denotes	change
T2715	10397-10401	RBR	denotes	more
T2716	10402-10409	JJ	denotes	gradual
T2717	10417-10419	IN	denotes	in
T2718	10420-10424	CC	denotes	both
T2719	10430-10435	NN	denotes	color
T2720	10425-10429	NN	denotes	hair
T2721	10436-10439	CC	denotes	and
T2722	10440-10444	NN	denotes	hair
T2723	10445-10451	NN	denotes	length
T2724	10452-10453	-LRB-	denotes	(
T2725	10460-10462	CD	denotes	1A
T2726	10453-10459	NN	denotes	Figure
T2727	10462-10463	SYM	denotes	–
T2728	10463-10465	CD	denotes	1D
T2729	10465-10466	-RRB-	denotes	)
T2730	10466-10467	.	denotes	.
T2731	10467-10699	sentence	denotes	Within the region of transition from dorsum to ventrum (Figure 1B), flank hairs from at/at mice become progressively shorter and exhibit increasing amounts of pheomelanin deposition progressing from the tip to the base of the hair.
T2732	10468-10474	IN	denotes	Within
T2733	10564-10570	VBP	denotes	become
T2734	10475-10478	DT	denotes	the
T2735	10479-10485	NN	denotes	region
T2736	10486-10488	IN	denotes	of
T2737	10489-10499	NN	denotes	transition
T2738	10500-10504	IN	denotes	from
T2739	10505-10511	NN	denotes	dorsum
T2740	10512-10514	IN	denotes	to
T2741	10515-10522	NN	denotes	ventrum
T2742	10523-10524	-LRB-	denotes	(
T2743	10524-10530	NN	denotes	Figure
T2744	10531-10533	CD	denotes	1B
T2745	10533-10534	-RRB-	denotes	)
T2746	10534-10536	,	denotes	,
T2747	10536-10541	NN	denotes	flank
T2748	10542-10547	NNS	denotes	hairs
T2749	10548-10552	IN	denotes	from
T2750	10553-10555	NN	denotes	at
T2751	10556-10558	NN	denotes	at
T2752	10555-10556	HYPH	denotes	/
T2753	10559-10563	NNS	denotes	mice
T2754	10571-10584	RB	denotes	progressively
T2755	10585-10592	JJR	denotes	shorter
T2756	10593-10596	CC	denotes	and
T2757	10597-10604	VBP	denotes	exhibit
T2758	10605-10615	VBG	denotes	increasing
T2759	10616-10623	NNS	denotes	amounts
T2760	10624-10626	IN	denotes	of
T2761	10627-10638	NN	denotes	pheomelanin
T2762	10639-10649	NN	denotes	deposition
T2763	10650-10661	VBG	denotes	progressing
T2764	10662-10666	IN	denotes	from
T2765	10667-10670	DT	denotes	the
T2766	10671-10674	NN	denotes	tip
T2767	10675-10677	IN	denotes	to
T2768	10678-10681	DT	denotes	the
T2769	10682-10686	NN	denotes	base
T2770	10687-10689	IN	denotes	of
T2771	10690-10693	DT	denotes	the
T2772	10694-10698	NN	denotes	hair
T2773	10698-10699	.	denotes	.
T2774	10699-10836	sentence	denotes	However, the region of transition for hair length is considerably broader than that for pigmentation and independent of Agouti genotype.
T2775	10700-10707	RB	denotes	However
T2776	10750-10752	VBZ	denotes	is
T2777	10707-10709	,	denotes	,
T2778	10709-10712	DT	denotes	the
T2779	10713-10719	NN	denotes	region
T2780	10720-10722	IN	denotes	of
T2781	10723-10733	NN	denotes	transition
T2782	10734-10737	IN	denotes	for
T2783	10738-10742	NN	denotes	hair
T2784	10743-10749	NN	denotes	length
T2785	10753-10765	RB	denotes	considerably
T2786	10766-10773	JJR	denotes	broader
T2787	10774-10778	IN	denotes	than
T2788	10779-10783	DT	denotes	that
T2789	10784-10787	IN	denotes	for
T2790	10788-10800	NN	denotes	pigmentation
T2791	10801-10804	CC	denotes	and
T2792	10805-10816	JJ	denotes	independent
T2793	10817-10819	IN	denotes	of
T2794	10820-10826	NN	denotes	Agouti
T2795	10827-10835	NN	denotes	genotype
T2796	10835-10836	.	denotes	.
T2797	10836-11020	sentence	denotes	Although hair-cycle timing varies along the rostrocaudal axis, measurements of absolute hair length for mice matched for age and rostrocaudal level are remarkably similar (Figure 1D).
T2798	10837-10845	IN	denotes	Although
T2799	10864-10870	VBZ	denotes	varies
T2800	10846-10850	NN	denotes	hair
T2801	10851-10856	NN	denotes	cycle
T2802	10850-10851	HYPH	denotes	-
T2803	10857-10863	NN	denotes	timing
T2804	10985-10988	VBP	denotes	are
T2805	10871-10876	IN	denotes	along
T2806	10877-10880	DT	denotes	the
T2807	10894-10898	NN	denotes	axis
T2808	10881-10893	JJ	denotes	rostrocaudal
T2809	10898-10900	,	denotes	,
T2810	10900-10912	NNS	denotes	measurements
T2811	10913-10915	IN	denotes	of
T2812	10916-10924	JJ	denotes	absolute
T2813	10930-10936	NN	denotes	length
T2814	10925-10929	NN	denotes	hair
T2815	10937-10940	IN	denotes	for
T2816	10941-10945	NNS	denotes	mice
T2817	10946-10953	VBN	denotes	matched
T2818	10954-10957	IN	denotes	for
T2819	10958-10961	NN	denotes	age
T2820	10962-10965	CC	denotes	and
T2821	10966-10978	JJ	denotes	rostrocaudal
T2822	10979-10984	NN	denotes	level
T2823	10989-10999	RB	denotes	remarkably
T2824	11000-11007	JJ	denotes	similar
T2825	11008-11009	-LRB-	denotes	(
T2826	11009-11015	NN	denotes	Figure
T2827	11016-11018	CD	denotes	1D
T2828	11018-11019	-RRB-	denotes	)
T2829	11019-11020	.	denotes	.
T2830	11020-11199	sentence	denotes	Furthermore, measurements of relative hair length for animals of different age, size, and Agouti genotype also are very similar when normalized to body circumference (Figure 1C).
T2831	11021-11032	RB	denotes	Furthermore
T2832	11132-11135	VBP	denotes	are
T2833	11032-11034	,	denotes	,
T2834	11034-11046	NNS	denotes	measurements
T2835	11047-11049	IN	denotes	of
T2836	11050-11058	JJ	denotes	relative
T2837	11064-11070	NN	denotes	length
T2838	11059-11063	NN	denotes	hair
T2839	11071-11074	IN	denotes	for
T2840	11075-11082	NNS	denotes	animals
T2841	11083-11085	IN	denotes	of
T2842	11086-11095	JJ	denotes	different
T2843	11096-11099	NN	denotes	age
T2844	11099-11101	,	denotes	,
T2845	11101-11105	NN	denotes	size
T2846	11105-11107	,	denotes	,
T2847	11107-11110	CC	denotes	and
T2848	11111-11117	NN	denotes	Agouti
T2849	11118-11126	NN	denotes	genotype
T2850	11127-11131	RB	denotes	also
T2851	11136-11140	RB	denotes	very
T2852	11141-11148	JJ	denotes	similar
T2853	11149-11153	WRB	denotes	when
T2854	11154-11164	VBN	denotes	normalized
T2855	11165-11167	IN	denotes	to
T2856	11168-11172	NN	denotes	body
T2857	11173-11186	NN	denotes	circumference
T2858	11187-11188	-LRB-	denotes	(
T2859	11188-11194	NN	denotes	Figure
T2860	11195-11197	CD	denotes	1C
T2861	11197-11198	-RRB-	denotes	)
T2862	11198-11199	.	denotes	.
T2863	11199-11469	sentence	denotes	Taken together, these observations indicate that variation of hair length along the dorsoventral axis is stereotyped and maintained through multiple hair cycles, with a transition in hair length that is gradual and encompasses the pigment-type transition in at/at mice.
T2864	11200-11205	VBN	denotes	Taken
T2865	11235-11243	VBP	denotes	indicate
T2866	11206-11214	RB	denotes	together
T2867	11214-11216	,	denotes	,
T2868	11216-11221	DT	denotes	these
T2869	11222-11234	NNS	denotes	observations
T2870	11244-11248	IN	denotes	that
T2871	11305-11316	VBN	denotes	stereotyped
T2872	11249-11258	NN	denotes	variation
T2873	11259-11261	IN	denotes	of
T2874	11262-11266	NN	denotes	hair
T2875	11267-11273	NN	denotes	length
T2876	11274-11279	IN	denotes	along
T2877	11280-11283	DT	denotes	the
T2878	11297-11301	NN	denotes	axis
T2879	11284-11296	JJ	denotes	dorsoventral
T2880	11302-11304	VBZ	denotes	is
T2881	11317-11320	CC	denotes	and
T2882	11321-11331	VBN	denotes	maintained
T2883	11332-11339	IN	denotes	through
T2884	11340-11348	JJ	denotes	multiple
T2885	11354-11360	NNS	denotes	cycles
T2886	11349-11353	NN	denotes	hair
T2887	11360-11362	,	denotes	,
T2888	11362-11366	IN	denotes	with
T2889	11367-11368	DT	denotes	a
T2890	11369-11379	NN	denotes	transition
T2891	11380-11382	IN	denotes	in
T2892	11383-11387	NN	denotes	hair
T2893	11388-11394	NN	denotes	length
T2894	11395-11399	WDT	denotes	that
T2895	11400-11402	VBZ	denotes	is
T2896	11403-11410	JJ	denotes	gradual
T2897	11411-11414	CC	denotes	and
T2898	11415-11426	VBZ	denotes	encompasses
T2899	11427-11430	DT	denotes	the
T2900	11444-11454	NN	denotes	transition
T2901	11431-11438	NN	denotes	pigment
T2902	11439-11443	NN	denotes	type
T2903	11438-11439	HYPH	denotes	-
T2904	11455-11457	IN	denotes	in
T2905	11458-11460	NN	denotes	at
T2906	11461-11463	NN	denotes	at
T2907	11460-11461	HYPH	denotes	/
T2908	11464-11468	NNS	denotes	mice
T2909	11468-11469	.	denotes	.
T2910	11469-12667	sentence	denotes	Figure 1 Dorsoventral Skin Characteristics (A) Skin slices from animals of different age and genotype demonstrate similar patterns of hair-length variation along the dorsoventral axis (scale bar = 1 cm). (B) Enlarged area from (A), demonstrating the transition in hair length and color in at/at mice (scale bar = 0.375 cm). (C) Proportional hair length for (A) plotted as a function of relative position along the dorsoventral axis. (D) Hair length plotted as a function of absolute position along the dorsoventral axis for 8-wk-old BA strain mice. (E) Proportion of zigzag hairs (± SEM) differs slightly between dorsum and ventrum of inbred mice (p < 0.0001, χ2 test, n = 1,958, 1,477, 1,579, 1,502). (F) Differences in dorsal and ventral skin development at P4.5 (scale bar = 1 mm, upper; 200 μm, lower). (G) Differences in hair melanin content and DOPA staining for dorsum (d), flank (f), and ventrum (v) in ae/ae and at/at mice. The upper panel also demonstrates a cream-colored appearance of the at/at ventrum. The middle panel shows representative awls (scale bar = 100 μm). The lower panel shows DOPA-stained dermis (scale bar = 200 μm). Dorsal and ventral skin develop at different rates.
T2911	12616-12622	JJ	denotes	Dorsal
T2912	12635-12639	NN	denotes	skin
T2913	12623-12626	CC	denotes	and
T2914	12627-12634	JJ	denotes	ventral
T2915	12640-12647	VBP	denotes	develop
T2916	12648-12650	IN	denotes	at
T2917	12651-12660	JJ	denotes	different
T2918	12661-12666	NNS	denotes	rates
T2919	12666-12667	.	denotes	.
T2920	12667-12893	sentence	denotes	Transverse sections of skin at postnatal day 4.5 (P4.5) exhibit dorsal hair follicles that are noticeably more developed than ventral hair follicles, along with a gradual dorsoventral decrease in dermal thickness (Figure 1F).
T2921	12668-12678	JJ	denotes	Transverse
T2922	12679-12687	NNS	denotes	sections
T2923	12724-12731	VBP	denotes	exhibit
T2924	12688-12690	IN	denotes	of
T2925	12691-12695	NN	denotes	skin
T2926	12696-12698	IN	denotes	at
T2927	12699-12708	JJ	denotes	postnatal
T2928	12709-12712	NN	denotes	day
T2929	12713-12716	CD	denotes	4.5
T2930	12717-12718	-LRB-	denotes	(
T2931	12718-12722	NN	denotes	P4.5
T2932	12722-12723	-RRB-	denotes	)
T2933	12732-12738	JJ	denotes	dorsal
T2934	12744-12753	NNS	denotes	follicles
T2935	12739-12743	NN	denotes	hair
T2936	12754-12758	WDT	denotes	that
T2937	12759-12762	VBP	denotes	are
T2938	12763-12773	RB	denotes	noticeably
T2939	12779-12788	JJ	denotes	developed
T2940	12774-12778	RBR	denotes	more
T2941	12789-12793	IN	denotes	than
T2942	12794-12801	JJ	denotes	ventral
T2943	12807-12816	NNS	denotes	follicles
T2944	12802-12806	NN	denotes	hair
T2945	12816-12818	,	denotes	,
T2946	12818-12823	IN	denotes	along
T2947	12824-12828	IN	denotes	with
T2948	12829-12830	DT	denotes	a
T2949	12852-12860	NN	denotes	decrease
T2950	12831-12838	JJ	denotes	gradual
T2951	12839-12851	JJ	denotes	dorsoventral
T2952	12861-12863	IN	denotes	in
T2953	12864-12870	JJ	denotes	dermal
T2954	12871-12880	NN	denotes	thickness
T2955	12881-12882	-LRB-	denotes	(
T2956	12882-12888	NN	denotes	Figure
T2957	12889-12891	CD	denotes	1F
T2958	12891-12892	-RRB-	denotes	)
T2959	12892-12893	.	denotes	.
T2960	12893-13090	sentence	denotes	However, differences in skin thickness disappear by 3–4 wk of age (Forsthoefel et al. 1966), and, overall, the proportion of different hair types is also similar in dorsa and ventra of adult mice.
T2961	12894-12901	RB	denotes	However
T2962	12933-12942	VBP	denotes	disappear
T2963	12901-12903	,	denotes	,
T2964	12903-12914	NNS	denotes	differences
T2965	12915-12917	IN	denotes	in
T2966	12918-12922	NN	denotes	skin
T2967	12923-12932	NN	denotes	thickness
T2968	12943-12945	IN	denotes	by
T2969	12946-12947	CD	denotes	3
T2970	12948-12949	CD	denotes	4
T2971	12947-12948	SYM	denotes	–
T2972	12950-12952	NN	denotes	wk
T2973	12953-12955	IN	denotes	of
T2974	12956-12959	NN	denotes	age
T2975	12960-12961	-LRB-	denotes	(
T2976	12961-12972	NNP	denotes	Forsthoefel
T2977	12973-12975	FW	denotes	et
T2978	12976-12979	FW	denotes	al.
T2979	12980-12984	CD	denotes	1966
T2980	12984-12985	-RRB-	denotes	)
T2981	12985-12987	,	denotes	,
T2982	12987-12990	CC	denotes	and
T2983	12990-12992	,	denotes	,
T2984	12992-12999	RB	denotes	overall
T2985	13040-13042	VBZ	denotes	is
T2986	12999-13001	,	denotes	,
T2987	13001-13004	DT	denotes	the
T2988	13005-13015	NN	denotes	proportion
T2989	13016-13018	IN	denotes	of
T2990	13019-13028	JJ	denotes	different
T2991	13034-13039	NNS	denotes	types
T2992	13029-13033	NN	denotes	hair
T2993	13043-13047	RB	denotes	also
T2994	13048-13055	JJ	denotes	similar
T2995	13056-13058	IN	denotes	in
T2996	13059-13064	NNS	denotes	dorsa
T2997	13065-13068	CC	denotes	and
T2998	13069-13075	NNS	denotes	ventra
T2999	13076-13078	IN	denotes	of
T3000	13079-13084	JJ	denotes	adult
T3001	13085-13089	NNS	denotes	mice
T3002	13089-13090	.	denotes	.
T3003	13090-13384	sentence	denotes	In age-matched inbred mice, we observed a small decrease in the ratio of undercoat hairs (zigzags) to overcoat hairs (auchenes, awls, and guard hairs) in dorsum compared to ventrum (Figure 1E), but there was no consistent difference in hair-type distribution for outbred mice (data not shown).
T3004	13091-13093	IN	denotes	In
T3005	13122-13130	VBD	denotes	observed
T3006	13094-13097	NN	denotes	age
T3007	13098-13105	VBN	denotes	matched
T3008	13097-13098	HYPH	denotes	-
T3009	13113-13117	NNS	denotes	mice
T3010	13106-13112	JJ	denotes	inbred
T3011	13117-13119	,	denotes	,
T3012	13119-13121	PRP	denotes	we
T3013	13131-13132	DT	denotes	a
T3014	13139-13147	NN	denotes	decrease
T3015	13133-13138	JJ	denotes	small
T3016	13148-13150	IN	denotes	in
T3017	13151-13154	DT	denotes	the
T3018	13155-13160	NN	denotes	ratio
T3019	13161-13163	IN	denotes	of
T3020	13164-13173	NN	denotes	undercoat
T3021	13174-13179	NNS	denotes	hairs
T3022	13180-13181	-LRB-	denotes	(
T3023	13181-13188	NNS	denotes	zigzags
T3024	13188-13189	-RRB-	denotes	)
T3025	13190-13192	IN	denotes	to
T3026	13193-13201	NN	denotes	overcoat
T3027	13202-13207	NNS	denotes	hairs
T3028	13208-13209	-LRB-	denotes	(
T3029	13209-13217	NNS	denotes	auchenes
T3030	13217-13219	,	denotes	,
T3031	13219-13223	NNS	denotes	awls
T3032	13223-13225	,	denotes	,
T3033	13225-13228	CC	denotes	and
T3034	13229-13234	NN	denotes	guard
T3035	13235-13240	NNS	denotes	hairs
T3036	13240-13241	-RRB-	denotes	)
T3037	13242-13244	IN	denotes	in
T3038	13245-13251	NN	denotes	dorsum
T3039	13252-13260	VBN	denotes	compared
T3040	13261-13263	IN	denotes	to
T3041	13264-13271	NN	denotes	ventrum
T3042	13272-13273	-LRB-	denotes	(
T3043	13273-13279	NN	denotes	Figure
T3044	13280-13282	CD	denotes	1E
T3045	13282-13283	-RRB-	denotes	)
T3046	13283-13285	,	denotes	,
T3047	13285-13288	CC	denotes	but
T3048	13289-13294	EX	denotes	there
T3049	13295-13298	VBD	denotes	was
T3050	13299-13301	DT	denotes	no
T3051	13313-13323	NN	denotes	difference
T3052	13302-13312	JJ	denotes	consistent
T3053	13324-13326	IN	denotes	in
T3054	13327-13331	NN	denotes	hair
T3055	13332-13336	NN	denotes	type
T3056	13331-13332	HYPH	denotes	-
T3057	13337-13349	NN	denotes	distribution
T3058	13350-13353	IN	denotes	for
T3059	13354-13361	JJ	denotes	outbred
T3060	13362-13366	NNS	denotes	mice
T3061	13367-13368	-LRB-	denotes	(
T3062	13377-13382	VBN	denotes	shown
T3063	13368-13372	NNS	denotes	data
T3064	13373-13376	RB	denotes	not
T3065	13382-13383	-RRB-	denotes	)
T3066	13383-13384	.	denotes	.
T3067	13384-13758	sentence	denotes	Differences between dorsal and ventral pigmentation of at/at mice are usually attributed to pigment-type differences caused by ventral-specific expression of Agouti, but animals homozygous for a null allele of Agouti, extreme nonagouti (ae), have ventral hairs that contain less melanin than dorsal hairs, giving a slightly paler appearance to the ventral coat (Figure 1G).
T3068	13385-13396	NNS	denotes	Differences
T3069	13463-13473	VBN	denotes	attributed
T3070	13397-13404	IN	denotes	between
T3071	13405-13411	JJ	denotes	dorsal
T3072	13424-13436	NN	denotes	pigmentation
T3073	13412-13415	CC	denotes	and
T3074	13416-13423	JJ	denotes	ventral
T3075	13437-13439	IN	denotes	of
T3076	13440-13442	NN	denotes	at
T3077	13443-13445	NN	denotes	at
T3078	13442-13443	HYPH	denotes	/
T3079	13446-13450	NNS	denotes	mice
T3080	13451-13454	VBP	denotes	are
T3081	13455-13462	RB	denotes	usually
T3082	13474-13476	IN	denotes	to
T3083	13477-13484	NN	denotes	pigment
T3084	13485-13489	NN	denotes	type
T3085	13484-13485	HYPH	denotes	-
T3086	13490-13501	NNS	denotes	differences
T3087	13502-13508	VBN	denotes	caused
T3088	13509-13511	IN	denotes	by
T3089	13512-13519	JJ	denotes	ventral
T3090	13520-13528	JJ	denotes	specific
T3091	13519-13520	HYPH	denotes	-
T3092	13529-13539	NN	denotes	expression
T3093	13540-13542	IN	denotes	of
T3094	13543-13549	NN	denotes	Agouti
T3095	13549-13551	,	denotes	,
T3096	13551-13554	CC	denotes	but
T3097	13555-13562	NNS	denotes	animals
T3098	13627-13631	VBP	denotes	have
T3099	13563-13573	JJ	denotes	homozygous
T3100	13574-13577	IN	denotes	for
T3101	13578-13579	DT	denotes	a
T3102	13585-13591	NN	denotes	allele
T3103	13580-13584	JJ	denotes	null
T3104	13592-13594	IN	denotes	of
T3105	13595-13601	NN	denotes	Agouti
T3106	13601-13603	,	denotes	,
T3107	13603-13610	JJ	denotes	extreme
T3108	13611-13620	NN	denotes	nonagouti
T3109	13621-13622	-LRB-	denotes	(
T3110	13622-13624	NN	denotes	ae
T3111	13624-13625	-RRB-	denotes	)
T3112	13625-13627	,	denotes	,
T3113	13632-13639	JJ	denotes	ventral
T3114	13640-13645	NNS	denotes	hairs
T3115	13646-13650	WDT	denotes	that
T3116	13651-13658	VBP	denotes	contain
T3117	13659-13663	JJR	denotes	less
T3118	13664-13671	NN	denotes	melanin
T3119	13672-13676	IN	denotes	than
T3120	13677-13683	JJ	denotes	dorsal
T3121	13684-13689	NNS	denotes	hairs
T3122	13689-13691	,	denotes	,
T3123	13691-13697	VBG	denotes	giving
T3124	13698-13699	DT	denotes	a
T3125	13715-13725	NN	denotes	appearance
T3126	13700-13708	RB	denotes	slightly
T3127	13709-13714	JJ	denotes	paler
T3128	13726-13728	IN	denotes	to
T3129	13729-13732	DT	denotes	the
T3130	13741-13745	NN	denotes	coat
T3131	13733-13740	JJ	denotes	ventral
T3132	13746-13747	-LRB-	denotes	(
T3133	13747-13753	NN	denotes	Figure
T3134	13754-13756	CD	denotes	1G
T3135	13756-13757	-RRB-	denotes	)
T3136	13757-13758	.	denotes	.
T3137	13758-13930	sentence	denotes	Using DOPA staining as an indicator of tyrosinase activity, we observed a gradual dorsoventral transition in isolated dermis preparations from P4.5 ae/ae mice (Figure 1G).
T3138	13759-13764	VBG	denotes	Using
T3139	13822-13830	VBD	denotes	observed
T3140	13765-13769	NN	denotes	DOPA
T3141	13770-13778	NN	denotes	staining
T3142	13779-13781	IN	denotes	as
T3143	13782-13784	DT	denotes	an
T3144	13785-13794	NN	denotes	indicator
T3145	13795-13797	IN	denotes	of
T3146	13798-13808	NN	denotes	tyrosinase
T3147	13809-13817	NN	denotes	activity
T3148	13817-13819	,	denotes	,
T3149	13819-13821	PRP	denotes	we
T3150	13831-13832	DT	denotes	a
T3151	13854-13864	NN	denotes	transition
T3152	13833-13840	JJ	denotes	gradual
T3153	13841-13853	JJ	denotes	dorsoventral
T3154	13865-13867	IN	denotes	in
T3155	13868-13876	VBN	denotes	isolated
T3156	13884-13896	NNS	denotes	preparations
T3157	13877-13883	NN	denotes	dermis
T3158	13897-13901	IN	denotes	from
T3159	13902-13906	NN	denotes	P4.5
T3160	13913-13917	NNS	denotes	mice
T3161	13907-13909	NN	denotes	ae
T3162	13910-13912	NN	denotes	ae
T3163	13909-13910	HYPH	denotes	/
T3164	13918-13919	-LRB-	denotes	(
T3165	13919-13925	NN	denotes	Figure
T3166	13926-13928	CD	denotes	1G
T3167	13928-13929	-RRB-	denotes	)
T3168	13929-13930	.	denotes	.
T3169	13930-14175	sentence	denotes	By contrast, skin from at/at mice reveal an abrupt dorsoventral transition of DOPA staining, which probably reflects the additive effects of reduced melanin content (as in ae/ae mice) and downregulation of tyrosinase activity induced by Agouti.
T3170	13931-13933	IN	denotes	By
T3171	13965-13971	VBP	denotes	reveal
T3172	13934-13942	NN	denotes	contrast
T3173	13942-13944	,	denotes	,
T3174	13944-13948	NN	denotes	skin
T3175	13949-13953	IN	denotes	from
T3176	13954-13956	NN	denotes	at
T3177	13957-13959	NN	denotes	at
T3178	13956-13957	HYPH	denotes	/
T3179	13960-13964	NNS	denotes	mice
T3180	13972-13974	DT	denotes	an
T3181	13995-14005	NN	denotes	transition
T3182	13975-13981	JJ	denotes	abrupt
T3183	13982-13994	JJ	denotes	dorsoventral
T3184	14006-14008	IN	denotes	of
T3185	14009-14013	NN	denotes	DOPA
T3186	14014-14022	NN	denotes	staining
T3187	14022-14024	,	denotes	,
T3188	14024-14029	WDT	denotes	which
T3189	14039-14047	VBZ	denotes	reflects
T3190	14030-14038	RB	denotes	probably
T3191	14048-14051	DT	denotes	the
T3192	14061-14068	NNS	denotes	effects
T3193	14052-14060	JJ	denotes	additive
T3194	14069-14071	IN	denotes	of
T3195	14072-14079	VBN	denotes	reduced
T3196	14088-14095	NN	denotes	content
T3197	14080-14087	NN	denotes	melanin
T3198	14096-14097	-LRB-	denotes	(
T3199	14097-14099	IN	denotes	as
T3200	14100-14102	IN	denotes	in
T3201	14103-14105	NN	denotes	ae
T3202	14106-14108	NN	denotes	ae
T3203	14105-14106	HYPH	denotes	/
T3204	14109-14113	NNS	denotes	mice
T3205	14113-14114	-RRB-	denotes	)
T3206	14115-14118	CC	denotes	and
T3207	14119-14133	NN	denotes	downregulation
T3208	14134-14136	IN	denotes	of
T3209	14137-14147	NN	denotes	tyrosinase
T3210	14148-14156	NN	denotes	activity
T3211	14157-14164	VBN	denotes	induced
T3212	14165-14167	IN	denotes	by
T3213	14168-14174	NN	denotes	Agouti
T3214	14174-14175	.	denotes	.
T3215	14175-14308	sentence	denotes	Melanin content of individual hairs is likely to be influenced both by the number of pigment cells and their follicular environment.
T3216	14176-14183	NN	denotes	Melanin
T3217	14184-14191	NN	denotes	content
T3218	14212-14214	VBZ	denotes	is
T3219	14192-14194	IN	denotes	of
T3220	14195-14205	JJ	denotes	individual
T3221	14206-14211	NNS	denotes	hairs
T3222	14215-14221	JJ	denotes	likely
T3223	14222-14224	TO	denotes	to
T3224	14228-14238	VBN	denotes	influenced
T3225	14225-14227	VB	denotes	be
T3226	14239-14243	CC	denotes	both
T3227	14244-14246	IN	denotes	by
T3228	14247-14250	DT	denotes	the
T3229	14251-14257	NN	denotes	number
T3230	14258-14260	IN	denotes	of
T3231	14261-14268	NN	denotes	pigment
T3232	14269-14274	NNS	denotes	cells
T3233	14275-14278	CC	denotes	and
T3234	14279-14284	PRP$	denotes	their
T3235	14296-14307	NN	denotes	environment
T3236	14285-14295	JJ	denotes	follicular
T3237	14307-14308	.	denotes	.
T3238	14308-14491	sentence	denotes	Regardless, dorsoventral differences in hair pigment content of ae/ae mice persist throughout multiple hair cycles into adulthood, similar to hair length (but unlike skin thickness).
T3239	14309-14319	RB	denotes	Regardless
T3240	14384-14391	VBP	denotes	persist
T3241	14319-14321	,	denotes	,
T3242	14321-14333	JJ	denotes	dorsoventral
T3243	14334-14345	NNS	denotes	differences
T3244	14346-14348	IN	denotes	in
T3245	14349-14353	NN	denotes	hair
T3246	14362-14369	NN	denotes	content
T3247	14354-14361	NN	denotes	pigment
T3248	14370-14372	IN	denotes	of
T3249	14373-14375	NN	denotes	ae
T3250	14376-14378	NN	denotes	ae
T3251	14375-14376	HYPH	denotes	/
T3252	14379-14383	NNS	denotes	mice
T3253	14392-14402	IN	denotes	throughout
T3254	14403-14411	JJ	denotes	multiple
T3255	14417-14423	NNS	denotes	cycles
T3256	14412-14416	NN	denotes	hair
T3257	14424-14428	IN	denotes	into
T3258	14429-14438	NN	denotes	adulthood
T3259	14438-14440	,	denotes	,
T3260	14440-14447	JJ	denotes	similar
T3261	14448-14450	IN	denotes	to
T3262	14451-14455	NN	denotes	hair
T3263	14456-14462	NN	denotes	length
T3264	14463-14464	-LRB-	denotes	(
T3265	14464-14467	CC	denotes	but
T3266	14468-14474	IN	denotes	unlike
T3267	14475-14479	NN	denotes	skin
T3268	14480-14489	NN	denotes	thickness
T3269	14489-14490	-RRB-	denotes	)
T3270	14490-14491	.	denotes	.
T3271	14491-14700	sentence	denotes	Thus, at least three characteristics distinguish dorsal from ventral skin: differences in pigment-type synthesis (depending on Agouti genotype), differences in hair length, and differences in melanin content.
T3272	14492-14496	RB	denotes	Thus
T3273	14529-14540	VBP	denotes	distinguish
T3274	14496-14498	,	denotes	,
T3275	14498-14500	RB	denotes	at
T3276	14507-14512	CD	denotes	three
T3277	14501-14506	RBS	denotes	least
T3278	14513-14528	NNS	denotes	characteristics
T3279	14541-14547	JJ	denotes	dorsal
T3280	14548-14552	IN	denotes	from
T3281	14553-14560	JJ	denotes	ventral
T3282	14561-14565	NN	denotes	skin
T3283	14565-14567	:	denotes	:
T3284	14567-14578	NNS	denotes	differences
T3285	14579-14581	IN	denotes	in
T3286	14582-14589	NN	denotes	pigment
T3287	14590-14594	NN	denotes	type
T3288	14589-14590	HYPH	denotes	-
T3289	14595-14604	NN	denotes	synthesis
T3290	14605-14606	-LRB-	denotes	(
T3291	14606-14615	VBG	denotes	depending
T3292	14616-14618	IN	denotes	on
T3293	14619-14625	NN	denotes	Agouti
T3294	14626-14634	NN	denotes	genotype
T3295	14634-14635	-RRB-	denotes	)
T3296	14635-14637	,	denotes	,
T3297	14637-14648	NNS	denotes	differences
T3298	14649-14651	IN	denotes	in
T3299	14652-14656	NN	denotes	hair
T3300	14657-14663	NN	denotes	length
T3301	14663-14665	,	denotes	,
T3302	14665-14668	CC	denotes	and
T3303	14669-14680	NNS	denotes	differences
T3304	14681-14683	IN	denotes	in
T3305	14684-14691	NN	denotes	melanin
T3306	14692-14699	NN	denotes	content
T3307	14699-14700	.	denotes	.
T3535	14702-14716	NN	denotes	Ventralization
T3536	14717-14719	IN	denotes	of
T3537	14720-14724	NN	denotes	Skin
T3538	14725-14735	NN	denotes	Morphology
T3539	14736-14738	IN	denotes	by
T3540	14739-14742	DT	denotes	the
T3541	14754-14762	NN	denotes	Mutation
T3542	14743-14749	JJ	denotes	droopy
T3543	14750-14753	NN	denotes	ear
T3544	14762-15093	sentence	denotes	Named after its effects on craniofacial morphology, droopy ear is a recessive mutation on mouse Chromosome 3; the original allele described more than 40 years ago by Curry (1959) is extinct, but a spontaneous remutation that occurred in Harwell, deH, is available through The Jackson Laboratory (Bar Harbor, Maine, United States).
T3545	14763-14768	VBN	denotes	Named
T3546	14826-14828	VBZ	denotes	is
T3547	14769-14774	IN	denotes	after
T3548	14775-14778	PRP$	denotes	its
T3549	14779-14786	NNS	denotes	effects
T3550	14787-14789	IN	denotes	on
T3551	14790-14802	JJ	denotes	craniofacial
T3552	14803-14813	NN	denotes	morphology
T3553	14813-14815	,	denotes	,
T3554	14815-14821	JJ	denotes	droopy
T3555	14822-14825	NN	denotes	ear
T3556	14942-14944	VBZ	denotes	is
T3557	14829-14830	DT	denotes	a
T3558	14841-14849	NN	denotes	mutation
T3559	14831-14840	JJ	denotes	recessive
T3560	14850-14852	IN	denotes	on
T3561	14853-14858	NN	denotes	mouse
T3562	14859-14869	NN	denotes	Chromosome
T3563	14870-14871	CD	denotes	3
T3564	14871-14872	:	denotes	;
T3565	14873-14876	DT	denotes	the
T3566	14886-14892	NN	denotes	allele
T3567	14877-14885	JJ	denotes	original
T3568	14893-14902	VBN	denotes	described
T3569	14903-14907	JJR	denotes	more
T3570	14913-14915	CD	denotes	40
T3571	14908-14912	IN	denotes	than
T3572	14916-14921	NNS	denotes	years
T3573	14922-14925	RB	denotes	ago
T3574	14926-14928	IN	denotes	by
T3575	14929-14934	NNP	denotes	Curry
T3576	14935-14936	-LRB-	denotes	(
T3577	14936-14940	CD	denotes	1959
T3578	14940-14941	-RRB-	denotes	)
T3579	14945-14952	JJ	denotes	extinct
T3580	14952-14954	,	denotes	,
T3581	14954-14957	CC	denotes	but
T3582	14958-14959	DT	denotes	a
T3583	14972-14982	NN	denotes	remutation
T3584	14960-14971	JJ	denotes	spontaneous
T3585	15014-15016	VBZ	denotes	is
T3586	14983-14987	WDT	denotes	that
T3587	14988-14996	VBD	denotes	occurred
T3588	14997-14999	IN	denotes	in
T3589	15000-15007	NNP	denotes	Harwell
T3590	15007-15009	,	denotes	,
T3591	15009-15012	NN	denotes	deH
T3592	15012-15014	,	denotes	,
T3593	15017-15026	JJ	denotes	available
T3594	15027-15034	IN	denotes	through
T3595	15035-15038	DT	denotes	The
T3596	15047-15057	NNP	denotes	Laboratory
T3597	15039-15046	NNP	denotes	Jackson
T3598	15058-15059	-LRB-	denotes	(
T3599	15063-15069	NNP	denotes	Harbor
T3600	15059-15062	NNP	denotes	Bar
T3601	15069-15071	,	denotes	,
T3602	15071-15076	NNP	denotes	Maine
T3603	15076-15078	,	denotes	,
T3604	15078-15084	NNP	denotes	United
T3605	15085-15091	NNP	denotes	States
T3606	15091-15092	-RRB-	denotes	)
T3607	15092-15093	.	denotes	.
T3608	15093-15390	sentence	denotes	External craniofacial malformations are the most obvious characteristic of deH/deH animals, including widely spaced eyes, small palpebral fissures, a broad nasal area, and a shortened skull held in an elevated position, which presumably causes or contributes to the abnormal position of the ears.
T3609	15094-15102	JJ	denotes	External
T3610	15116-15129	NNS	denotes	malformations
T3611	15103-15115	JJ	denotes	craniofacial
T3612	15130-15133	VBP	denotes	are
T3613	15134-15137	DT	denotes	the
T3614	15151-15165	NN	denotes	characteristic
T3615	15138-15142	RBS	denotes	most
T3616	15143-15150	JJ	denotes	obvious
T3617	15166-15168	IN	denotes	of
T3618	15169-15172	NN	denotes	deH
T3619	15173-15176	NN	denotes	deH
T3620	15172-15173	HYPH	denotes	/
T3621	15177-15184	NNS	denotes	animals
T3622	15184-15186	,	denotes	,
T3623	15186-15195	VBG	denotes	including
T3624	15196-15202	RB	denotes	widely
T3625	15203-15209	VBN	denotes	spaced
T3626	15210-15214	NNS	denotes	eyes
T3627	15214-15216	,	denotes	,
T3628	15216-15221	JJ	denotes	small
T3629	15232-15240	NNS	denotes	fissures
T3630	15222-15231	JJ	denotes	palpebral
T3631	15240-15242	,	denotes	,
T3632	15242-15243	DT	denotes	a
T3633	15256-15260	NN	denotes	area
T3634	15244-15249	JJ	denotes	broad
T3635	15250-15255	JJ	denotes	nasal
T3636	15260-15262	,	denotes	,
T3637	15262-15265	CC	denotes	and
T3638	15266-15267	DT	denotes	a
T3639	15278-15283	NN	denotes	skull
T3640	15268-15277	JJ	denotes	shortened
T3641	15284-15288	VBN	denotes	held
T3642	15289-15291	IN	denotes	in
T3643	15292-15294	DT	denotes	an
T3644	15304-15312	NN	denotes	position
T3645	15295-15303	JJ	denotes	elevated
T3646	15312-15314	,	denotes	,
T3647	15314-15319	WDT	denotes	which
T3648	15331-15337	VBZ	denotes	causes
T3649	15320-15330	RB	denotes	presumably
T3650	15338-15340	CC	denotes	or
T3651	15341-15352	VBZ	denotes	contributes
T3652	15353-15355	IN	denotes	to
T3653	15356-15359	DT	denotes	the
T3654	15369-15377	NN	denotes	position
T3655	15360-15368	JJ	denotes	abnormal
T3656	15378-15380	IN	denotes	of
T3657	15381-15384	DT	denotes	the
T3658	15385-15389	NNS	denotes	ears
T3659	15389-15390	.	denotes	.
T3660	15390-15744	sentence	denotes	We became interested in droopy ear because the original allele was described to affect pigment pattern in a way that suggests a possible dorsal to ventral transformation: “On a genetic background (at and AW) which causes the belly hair to be lighter than the back hair, the belly hair comes up farther round the sides of the body and face” (Curry 1959).
T3661	15391-15393	PRP	denotes	We
T3662	15394-15400	VBD	denotes	became
T3663	15676-15681	VBZ	denotes	comes
T3664	15401-15411	JJ	denotes	interested
T3665	15412-15414	IN	denotes	in
T3666	15415-15421	JJ	denotes	droopy
T3667	15422-15425	NN	denotes	ear
T3668	15426-15433	IN	denotes	because
T3669	15458-15467	VBN	denotes	described
T3670	15434-15437	DT	denotes	the
T3671	15447-15453	NN	denotes	allele
T3672	15438-15446	JJ	denotes	original
T3673	15454-15457	VBD	denotes	was
T3674	15468-15470	TO	denotes	to
T3675	15471-15477	VB	denotes	affect
T3676	15478-15485	NN	denotes	pigment
T3677	15486-15493	NN	denotes	pattern
T3678	15494-15496	IN	denotes	in
T3679	15497-15498	DT	denotes	a
T3680	15499-15502	NN	denotes	way
T3681	15503-15507	WDT	denotes	that
T3682	15508-15516	VBZ	denotes	suggests
T3683	15517-15518	DT	denotes	a
T3684	15546-15560	NN	denotes	transformation
T3685	15519-15527	JJ	denotes	possible
T3686	15528-15534	JJ	denotes	dorsal
T3687	15535-15537	IN	denotes	to
T3688	15538-15545	JJ	denotes	ventral
T3689	15560-15562	:	denotes	:
T3690	15562-15563	``	denotes	“
T3691	15563-15565	IN	denotes	On
T3692	15566-15567	DT	denotes	a
T3693	15576-15586	NN	denotes	background
T3694	15568-15575	JJ	denotes	genetic
T3695	15587-15588	-LRB-	denotes	(
T3696	15588-15590	NN	denotes	at
T3697	15591-15594	CC	denotes	and
T3698	15595-15597	NN	denotes	AW
T3699	15597-15598	-RRB-	denotes	)
T3700	15599-15604	WDT	denotes	which
T3701	15605-15611	VBZ	denotes	causes
T3702	15612-15615	DT	denotes	the
T3703	15622-15626	NN	denotes	hair
T3704	15616-15621	NN	denotes	belly
T3705	15630-15632	VB	denotes	be
T3706	15627-15629	TO	denotes	to
T3707	15633-15640	JJR	denotes	lighter
T3708	15641-15645	IN	denotes	than
T3709	15646-15649	DT	denotes	the
T3710	15655-15659	NN	denotes	hair
T3711	15650-15654	NN	denotes	back
T3712	15659-15661	,	denotes	,
T3713	15661-15664	DT	denotes	the
T3714	15671-15675	NN	denotes	hair
T3715	15665-15670	NN	denotes	belly
T3716	15682-15684	RP	denotes	up
T3717	15685-15692	RBR	denotes	farther
T3718	15693-15698	IN	denotes	round
T3719	15699-15702	DT	denotes	the
T3720	15703-15708	NNS	denotes	sides
T3721	15709-15711	IN	denotes	of
T3722	15712-15715	DT	denotes	the
T3723	15716-15720	NN	denotes	body
T3724	15721-15724	CC	denotes	and
T3725	15725-15729	NN	denotes	face
T3726	15729-15730	''	denotes	”
T3727	15731-15732	-LRB-	denotes	(
T3728	15732-15737	NNP	denotes	Curry
T3729	15738-15742	CD	denotes	1959
T3730	15742-15743	-RRB-	denotes	)
T3731	15743-15744	.	denotes	.
T3732	15744-15964	sentence	denotes	An abnormal dorsoventral pigment pattern is readily apparent in at/at; deH/deH mice, but comparison to nonmutant animals is more accurately described in terms of ventral, lateral, and dorsal regions (Figures 1G and 2A).
T3733	15745-15747	DT	denotes	An
T3734	15778-15785	NN	denotes	pattern
T3735	15748-15756	JJ	denotes	abnormal
T3736	15757-15769	JJ	denotes	dorsoventral
T3737	15770-15777	NN	denotes	pigment
T3738	15786-15788	VBZ	denotes	is
T3739	15789-15796	RB	denotes	readily
T3740	15797-15805	JJ	denotes	apparent
T3741	15806-15808	IN	denotes	in
T3742	15809-15811	NN	denotes	at
T3743	15812-15814	NN	denotes	at
T3744	15811-15812	HYPH	denotes	/
T3745	15824-15828	NNS	denotes	mice
T3746	15814-15815	,	denotes	;
T3747	15816-15819	NN	denotes	deH
T3748	15820-15823	NN	denotes	deH
T3749	15819-15820	HYPH	denotes	/
T3750	15828-15830	,	denotes	,
T3751	15830-15833	CC	denotes	but
T3752	15834-15844	NN	denotes	comparison
T3753	15885-15894	VBN	denotes	described
T3754	15845-15847	IN	denotes	to
T3755	15848-15857	JJ	denotes	nonmutant
T3756	15858-15865	NNS	denotes	animals
T3757	15866-15868	VBZ	denotes	is
T3758	15869-15873	RBR	denotes	more
T3759	15874-15884	RB	denotes	accurately
T3760	15895-15897	IN	denotes	in
T3761	15898-15903	NNS	denotes	terms
T3762	15904-15906	IN	denotes	of
T3763	15907-15914	JJ	denotes	ventral
T3764	15936-15943	NNS	denotes	regions
T3765	15914-15916	,	denotes	,
T3766	15916-15923	JJ	denotes	lateral
T3767	15923-15925	,	denotes	,
T3768	15925-15928	CC	denotes	and
T3769	15929-15935	JJ	denotes	dorsal
T3770	15944-15945	-LRB-	denotes	(
T3771	15953-15955	CD	denotes	1G
T3772	15945-15952	NNS	denotes	Figures
T3773	15956-15959	CC	denotes	and
T3774	15960-15962	CD	denotes	2A
T3775	15962-15963	-RRB-	denotes	)
T3776	15963-15964	.	denotes	.
T3777	15964-16229	sentence	denotes	The ventral region has short hairs with a gray base and cream-colored tip whose boundary coincides with the limb–body wall junction; both the appearance of this region and position of the boundary are approximately similar in at/at compared to at/at; deH/deH mice.
T3778	15965-15968	DT	denotes	The
T3779	15977-15983	NN	denotes	region
T3780	15969-15976	JJ	denotes	ventral
T3781	15984-15987	VBZ	denotes	has
T3782	16162-16165	VBP	denotes	are
T3783	15988-15993	JJ	denotes	short
T3784	15994-15999	NNS	denotes	hairs
T3785	16000-16004	IN	denotes	with
T3786	16005-16006	DT	denotes	a
T3787	16012-16016	NN	denotes	base
T3788	16007-16011	JJ	denotes	gray
T3789	16017-16020	CC	denotes	and
T3790	16021-16026	NN	denotes	cream
T3791	16027-16034	VBN	denotes	colored
T3792	16026-16027	HYPH	denotes	-
T3793	16035-16038	NN	denotes	tip
T3794	16039-16044	WP$	denotes	whose
T3795	16045-16053	NN	denotes	boundary
T3796	16054-16063	VBZ	denotes	coincides
T3797	16064-16068	IN	denotes	with
T3798	16069-16072	DT	denotes	the
T3799	16088-16096	NN	denotes	junction
T3800	16073-16077	NN	denotes	limb
T3801	16078-16082	NN	denotes	body
T3802	16077-16078	HYPH	denotes	–
T3803	16083-16087	NN	denotes	wall
T3804	16096-16097	:	denotes	;
T3805	16098-16102	CC	denotes	both
T3806	16107-16117	NN	denotes	appearance
T3807	16103-16106	DT	denotes	the
T3808	16118-16120	IN	denotes	of
T3809	16121-16125	DT	denotes	this
T3810	16126-16132	NN	denotes	region
T3811	16133-16136	CC	denotes	and
T3812	16137-16145	NN	denotes	position
T3813	16146-16148	IN	denotes	of
T3814	16149-16152	DT	denotes	the
T3815	16153-16161	NN	denotes	boundary
T3816	16166-16179	RB	denotes	approximately
T3817	16180-16187	JJ	denotes	similar
T3818	16188-16190	IN	denotes	in
T3819	16191-16193	NN	denotes	at
T3820	16194-16196	NN	denotes	at
T3821	16193-16194	HYPH	denotes	/
T3822	16224-16228	NNS	denotes	mice
T3823	16197-16205	VBN	denotes	compared
T3824	16206-16208	IN	denotes	to
T3825	16209-16211	NN	denotes	at
T3826	16212-16214	NN	denotes	at
T3827	16211-16212	HYPH	denotes	/
T3828	16214-16215	,	denotes	;
T3829	16216-16219	NN	denotes	deH
T3830	16220-16223	NN	denotes	deH
T3831	16219-16220	HYPH	denotes	/
T3832	16228-16229	.	denotes	.
T3833	16229-16597	sentence	denotes	The lateral region contains yellow hairs of progressively increasing length; in at/at mice, the lateral region appears as a thin yellow stripe along the flank, but in at/at; deH/deH mice, the lateral region is considerably expanded with a diffuse boundary along the dorsal flank, and a dorsal eumelanic region whose size is correspondingly reduced (Figure 2A and 2B).
T3834	16230-16233	DT	denotes	The
T3835	16242-16248	NN	denotes	region
T3836	16234-16241	JJ	denotes	lateral
T3837	16249-16257	VBZ	denotes	contains
T3838	16341-16348	VBZ	denotes	appears
T3839	16258-16264	JJ	denotes	yellow
T3840	16265-16270	NNS	denotes	hairs
T3841	16271-16273	IN	denotes	of
T3842	16274-16287	RB	denotes	progressively
T3843	16288-16298	VBG	denotes	increasing
T3844	16299-16305	NN	denotes	length
T3845	16305-16306	:	denotes	;
T3846	16307-16309	IN	denotes	in
T3847	16310-16312	NN	denotes	at
T3848	16313-16315	NN	denotes	at
T3849	16312-16313	HYPH	denotes	/
T3850	16316-16320	NNS	denotes	mice
T3851	16320-16322	,	denotes	,
T3852	16322-16325	DT	denotes	the
T3853	16334-16340	NN	denotes	region
T3854	16326-16333	JJ	denotes	lateral
T3855	16349-16351	IN	denotes	as
T3856	16352-16353	DT	denotes	a
T3857	16366-16372	NN	denotes	stripe
T3858	16354-16358	JJ	denotes	thin
T3859	16359-16365	JJ	denotes	yellow
T3860	16373-16378	IN	denotes	along
T3861	16379-16382	DT	denotes	the
T3862	16383-16388	NN	denotes	flank
T3863	16388-16390	,	denotes	,
T3864	16390-16393	CC	denotes	but
T3865	16394-16396	IN	denotes	in
T3866	16437-16439	VBZ	denotes	is
T3867	16397-16399	NN	denotes	at
T3868	16400-16402	NN	denotes	at
T3869	16399-16400	HYPH	denotes	/
T3870	16412-16416	NNS	denotes	mice
T3871	16402-16403	,	denotes	;
T3872	16404-16407	NN	denotes	deH
T3873	16408-16411	NN	denotes	deH
T3874	16407-16408	HYPH	denotes	/
T3875	16416-16418	,	denotes	,
T3876	16418-16421	DT	denotes	the
T3877	16430-16436	NN	denotes	region
T3878	16422-16429	JJ	denotes	lateral
T3879	16440-16452	RB	denotes	considerably
T3880	16453-16461	JJ	denotes	expanded
T3881	16462-16466	IN	denotes	with
T3882	16467-16468	DT	denotes	a
T3883	16477-16485	NN	denotes	boundary
T3884	16469-16476	JJ	denotes	diffuse
T3885	16486-16491	IN	denotes	along
T3886	16492-16495	DT	denotes	the
T3887	16503-16508	NN	denotes	flank
T3888	16496-16502	JJ	denotes	dorsal
T3889	16508-16510	,	denotes	,
T3890	16510-16513	CC	denotes	and
T3891	16514-16515	DT	denotes	a
T3892	16533-16539	NN	denotes	region
T3893	16516-16522	JJ	denotes	dorsal
T3894	16523-16532	JJ	denotes	eumelanic
T3895	16540-16545	WP$	denotes	whose
T3896	16546-16550	NN	denotes	size
T3897	16570-16577	VBN	denotes	reduced
T3898	16551-16553	VBZ	denotes	is
T3899	16554-16569	RB	denotes	correspondingly
T3900	16578-16579	-LRB-	denotes	(
T3901	16586-16588	CD	denotes	2A
T3902	16579-16585	NN	denotes	Figure
T3903	16589-16592	CC	denotes	and
T3904	16593-16595	CD	denotes	2B
T3905	16595-16596	-RRB-	denotes	)
T3906	16596-16597	.	denotes	.
T3907	16597-16815	sentence	denotes	Total body size is smaller in mutant compared to nonmutant animals, but the proportion of body circumference occupied by the lateral region in mutant animals is increased about 2-fold, from 11.9% to 22.2% (Figure 2C).
T3908	16598-16603	JJ	denotes	Total
T3909	16609-16613	NN	denotes	size
T3910	16604-16608	NN	denotes	body
T3911	16614-16616	VBZ	denotes	is
T3912	16617-16624	JJR	denotes	smaller
T3913	16625-16627	IN	denotes	in
T3914	16628-16634	JJ	denotes	mutant
T3915	16635-16643	VBN	denotes	compared
T3916	16644-16646	IN	denotes	to
T3917	16647-16656	JJ	denotes	nonmutant
T3918	16657-16664	NNS	denotes	animals
T3919	16664-16666	,	denotes	,
T3920	16666-16669	CC	denotes	but
T3921	16670-16673	DT	denotes	the
T3922	16674-16684	NN	denotes	proportion
T3923	16759-16768	VBN	denotes	increased
T3924	16685-16687	IN	denotes	of
T3925	16688-16692	NN	denotes	body
T3926	16693-16706	NN	denotes	circumference
T3927	16707-16715	VBN	denotes	occupied
T3928	16716-16718	IN	denotes	by
T3929	16719-16722	DT	denotes	the
T3930	16731-16737	NN	denotes	region
T3931	16723-16730	JJ	denotes	lateral
T3932	16738-16740	IN	denotes	in
T3933	16741-16747	JJ	denotes	mutant
T3934	16748-16755	NNS	denotes	animals
T3935	16756-16758	VBZ	denotes	is
T3936	16769-16774	RB	denotes	about
T3937	16775-16776	CD	denotes	2
T3938	16777-16781	RB	denotes	fold
T3939	16776-16777	HYPH	denotes	-
T3940	16781-16783	,	denotes	,
T3941	16783-16787	IN	denotes	from
T3942	16788-16792	CD	denotes	11.9
T3943	16792-16793	NN	denotes	%
T3944	16794-16796	IN	denotes	to
T3945	16797-16801	CD	denotes	22.2
T3946	16801-16802	NN	denotes	%
T3947	16803-16804	-LRB-	denotes	(
T3948	16804-16810	NN	denotes	Figure
T3949	16811-16813	CD	denotes	2C
T3950	16813-16814	-RRB-	denotes	)
T3951	16814-16815	.	denotes	.
T3952	16815-17174	sentence	denotes	The proportion of the ventral cream-colored region is also expanded a small amount, 47.9% in mutant compared to 37.8% in nonmutant animals, but expansion of the lateral region, which occurs at all levels of the body, including the limbs and the cranium (but not the whisker pad), is the major feature responsible for the ventralized appearance caused by deH.
T3953	16816-16819	DT	denotes	The
T3954	16820-16830	NN	denotes	proportion
T3955	16875-16883	VBN	denotes	expanded
T3956	16831-16833	IN	denotes	of
T3957	16834-16837	DT	denotes	the
T3958	16860-16866	NN	denotes	region
T3959	16838-16845	JJ	denotes	ventral
T3960	16846-16851	NN	denotes	cream
T3961	16852-16859	VBN	denotes	colored
T3962	16851-16852	HYPH	denotes	-
T3963	16867-16869	VBZ	denotes	is
T3964	16870-16874	RB	denotes	also
T3965	16884-16885	DT	denotes	a
T3966	16892-16898	NN	denotes	amount
T3967	16886-16891	JJ	denotes	small
T3968	16898-16900	,	denotes	,
T3969	16900-16904	CD	denotes	47.9
T3970	16904-16905	NN	denotes	%
T3971	16906-16908	IN	denotes	in
T3972	16909-16915	JJ	denotes	mutant
T3973	16916-16924	VBN	denotes	compared
T3974	16925-16927	IN	denotes	to
T3975	16928-16932	CD	denotes	37.8
T3976	16932-16933	NN	denotes	%
T3977	16934-16936	IN	denotes	in
T3978	16937-16946	JJ	denotes	nonmutant
T3979	16947-16954	NNS	denotes	animals
T3980	16954-16956	,	denotes	,
T3981	16956-16959	CC	denotes	but
T3982	16960-16969	NN	denotes	expansion
T3983	17096-17098	VBZ	denotes	is
T3984	16970-16972	IN	denotes	of
T3985	16973-16976	DT	denotes	the
T3986	16985-16991	NN	denotes	region
T3987	16977-16984	JJ	denotes	lateral
T3988	16991-16993	,	denotes	,
T3989	16993-16998	WDT	denotes	which
T3990	16999-17005	VBZ	denotes	occurs
T3991	17006-17008	IN	denotes	at
T3992	17009-17012	DT	denotes	all
T3993	17013-17019	NNS	denotes	levels
T3994	17020-17022	IN	denotes	of
T3995	17023-17026	DT	denotes	the
T3996	17027-17031	NN	denotes	body
T3997	17031-17033	,	denotes	,
T3998	17033-17042	VBG	denotes	including
T3999	17043-17046	DT	denotes	the
T4000	17047-17052	NNS	denotes	limbs
T4001	17053-17056	CC	denotes	and
T4002	17057-17060	DT	denotes	the
T4003	17061-17068	NN	denotes	cranium
T4004	17069-17070	-LRB-	denotes	(
T4005	17070-17073	CC	denotes	but
T4006	17074-17077	RB	denotes	not
T4007	17078-17081	DT	denotes	the
T4008	17090-17093	NN	denotes	pad
T4009	17082-17089	NN	denotes	whisker
T4010	17093-17094	-RRB-	denotes	)
T4011	17094-17096	,	denotes	,
T4012	17099-17102	DT	denotes	the
T4013	17109-17116	NN	denotes	feature
T4014	17103-17108	JJ	denotes	major
T4015	17117-17128	JJ	denotes	responsible
T4016	17129-17132	IN	denotes	for
T4017	17133-17136	DT	denotes	the
T4018	17149-17159	NN	denotes	appearance
T4019	17137-17148	VBN	denotes	ventralized
T4020	17160-17166	VBN	denotes	caused
T4021	17167-17169	IN	denotes	by
T4022	17170-17173	NN	denotes	deH
T4023	17173-17174	.	denotes	.
T4024	17174-18639	sentence	denotes	Figure 2 The deH Pigmentation Phenotype (A) 10-wk-old deH/deH and nonmutant animals on a at background. A thin stripe of yellow hair normally separates the dorsal black hairs from the ventral cream hairs. In deH, the yellow stripe is extended dorsally, and the boundary between the yellow and the black hairs is fuzzier. (B) Skin slices taken from 1.5-mo-old deH/deH and nonmutant littermates (scale bar = 0.5 cm). (C) Proportion of total skin area as determined by observation of pelts taken from the interlimb region. The proportion occupied by the yellow lateral compartment (± SEM) differs between mutant and nonmutant littermate flanks (p < 0.0005, paired t-test, n = 6 pairs). There is also (data not shown) a small increase in the proportion of total skin area occupied by the ventral cream-colored compartment, 47.9 % in mutant compared to 37.8% in nonmutant (p < 0.005, paired t-test, n = 6 pairs). (D) On an ae/ae background, the extent of dorsal skin pigmentation is reduced in deH/deH neonates (P3.5). (E) Hair length in a representative pair of 1.5-mo-old deH/deH and nonmutant littermates, averaged over three skin slices at different rostrocaudal levels, and plotted as a function of the absolute distance from middorsum or the percentage of total slice length. To investigate whether deH affects other dorsoventral skin characteristics besides pigment-type switching, we examined its effects on hair length and pigmentation in an ae/ae background.
T4025	18453-18455	TO	denotes	To
T4026	18456-18467	VB	denotes	investigate
T4027	18563-18571	VBD	denotes	examined
T4028	18468-18475	IN	denotes	whether
T4029	18480-18487	VBZ	denotes	affects
T4030	18476-18479	NN	denotes	deH
T4031	18488-18493	JJ	denotes	other
T4032	18512-18527	NNS	denotes	characteristics
T4033	18494-18506	JJ	denotes	dorsoventral
T4034	18507-18511	NN	denotes	skin
T4035	18528-18535	IN	denotes	besides
T4036	18536-18543	NN	denotes	pigment
T4037	18544-18548	NN	denotes	type
T4038	18543-18544	HYPH	denotes	-
T4039	18549-18558	VBG	denotes	switching
T4040	18558-18560	,	denotes	,
T4041	18560-18562	PRP	denotes	we
T4042	18572-18575	PRP$	denotes	its
T4043	18576-18583	NNS	denotes	effects
T4044	18584-18586	IN	denotes	on
T4045	18587-18591	NN	denotes	hair
T4046	18592-18598	NN	denotes	length
T4047	18599-18602	CC	denotes	and
T4048	18603-18615	NN	denotes	pigmentation
T4049	18616-18618	IN	denotes	in
T4050	18619-18621	DT	denotes	an
T4051	18628-18638	NN	denotes	background
T4052	18622-18624	NN	denotes	ae
T4053	18625-18627	NN	denotes	ae
T4054	18624-18625	HYPH	denotes	/
T4055	18638-18639	.	denotes	.
T4056	18639-18880	sentence	denotes	Overall, deH causes a small but consistent reduction in hair length in both dorsum and ventrum; when mutant and nonmutant animals are normalized for body circumference, reduced hair length is most apparent in the lateral region (Figure 2E).
T4057	18640-18647	RB	denotes	Overall
T4058	18653-18659	VBZ	denotes	causes
T4059	18647-18649	,	denotes	,
T4060	18649-18652	NN	denotes	deH
T4061	18829-18831	VBZ	denotes	is
T4062	18660-18661	DT	denotes	a
T4063	18683-18692	NN	denotes	reduction
T4064	18662-18667	JJ	denotes	small
T4065	18668-18671	CC	denotes	but
T4066	18672-18682	JJ	denotes	consistent
T4067	18693-18695	IN	denotes	in
T4068	18696-18700	NN	denotes	hair
T4069	18701-18707	NN	denotes	length
T4070	18708-18710	IN	denotes	in
T4071	18711-18715	CC	denotes	both
T4072	18716-18722	NN	denotes	dorsum
T4073	18723-18726	CC	denotes	and
T4074	18727-18734	NN	denotes	ventrum
T4075	18734-18735	:	denotes	;
T4076	18736-18740	WRB	denotes	when
T4077	18774-18784	VBN	denotes	normalized
T4078	18741-18747	JJ	denotes	mutant
T4079	18762-18769	NNS	denotes	animals
T4080	18748-18751	CC	denotes	and
T4081	18752-18761	JJ	denotes	nonmutant
T4082	18770-18773	VBP	denotes	are
T4083	18785-18788	IN	denotes	for
T4084	18789-18793	NN	denotes	body
T4085	18794-18807	NN	denotes	circumference
T4086	18807-18809	,	denotes	,
T4087	18809-18816	JJ	denotes	reduced
T4088	18822-18828	NN	denotes	length
T4089	18817-18821	NN	denotes	hair
T4090	18832-18836	RBS	denotes	most
T4091	18837-18845	JJ	denotes	apparent
T4092	18846-18848	IN	denotes	in
T4093	18849-18852	DT	denotes	the
T4094	18861-18867	NN	denotes	region
T4095	18853-18860	JJ	denotes	lateral
T4096	18868-18869	-LRB-	denotes	(
T4097	18869-18875	NN	denotes	Figure
T4098	18876-18878	CD	denotes	2E
T4099	18878-18879	-RRB-	denotes	)
T4100	18879-18880	.	denotes	.
T4101	18880-19019	sentence	denotes	Adult ae/ae; deH/deH animals exhibit body-size reduction and skeletal abnormalities, but display no coat-color phenotype (data not shown).
T4102	18881-18886	JJ	denotes	Adult
T4103	18902-18909	NNS	denotes	animals
T4104	18887-18889	NN	denotes	ae
T4105	18890-18892	NN	denotes	ae
T4106	18889-18890	HYPH	denotes	/
T4107	18892-18893	,	denotes	;
T4108	18894-18897	NN	denotes	deH
T4109	18898-18901	NN	denotes	deH
T4110	18897-18898	HYPH	denotes	/
T4111	18910-18917	VBP	denotes	exhibit
T4112	18918-18922	NN	denotes	body
T4113	18923-18927	NN	denotes	size
T4114	18922-18923	HYPH	denotes	-
T4115	18928-18937	NN	denotes	reduction
T4116	18938-18941	CC	denotes	and
T4117	18942-18950	JJ	denotes	skeletal
T4118	18951-18964	NNS	denotes	abnormalities
T4119	18964-18966	,	denotes	,
T4120	18966-18969	CC	denotes	but
T4121	18970-18977	VBP	denotes	display
T4122	18978-18980	DT	denotes	no
T4123	18992-19001	NN	denotes	phenotype
T4124	18981-18985	NN	denotes	coat
T4125	18986-18991	NN	denotes	color
T4126	18985-18986	HYPH	denotes	-
T4127	19002-19003	-LRB-	denotes	(
T4128	19012-19017	VBN	denotes	shown
T4129	19003-19007	NNS	denotes	data
T4130	19008-19011	RB	denotes	not
T4131	19017-19018	-RRB-	denotes	)
T4132	19018-19019	.	denotes	.
T4133	19019-19218	sentence	denotes	However, ae/ae and ae/ae; deH/deH neonates are clearly distinguishable in the first few days after birth, when a dorsoventral gradient of melanogenic activity is apparent under the skin (Figure 2D).
T4134	19020-19027	RB	denotes	However
T4135	19063-19066	VBP	denotes	are
T4136	19027-19029	,	denotes	,
T4137	19029-19031	NN	denotes	ae
T4138	19032-19034	NN	denotes	ae
T4139	19031-19032	SYM	denotes	/
T4140	19054-19062	NNS	denotes	neonates
T4141	19035-19038	CC	denotes	and
T4142	19039-19041	NN	denotes	ae
T4143	19042-19044	NN	denotes	ae
T4144	19041-19042	SYM	denotes	/
T4145	19044-19045	,	denotes	;
T4146	19046-19049	NN	denotes	deH
T4147	19050-19053	NN	denotes	deH
T4148	19049-19050	HYPH	denotes	/
T4149	19067-19074	RB	denotes	clearly
T4150	19075-19090	JJ	denotes	distinguishable
T4151	19091-19093	IN	denotes	in
T4152	19094-19097	DT	denotes	the
T4153	19108-19112	NNS	denotes	days
T4154	19098-19103	JJ	denotes	first
T4155	19104-19107	JJ	denotes	few
T4156	19113-19118	IN	denotes	after
T4157	19119-19124	NN	denotes	birth
T4158	19124-19126	,	denotes	,
T4159	19126-19130	WRB	denotes	when
T4160	19179-19181	VBZ	denotes	is
T4161	19131-19132	DT	denotes	a
T4162	19146-19154	NN	denotes	gradient
T4163	19133-19145	JJ	denotes	dorsoventral
T4164	19155-19157	IN	denotes	of
T4165	19158-19169	JJ	denotes	melanogenic
T4166	19170-19178	NN	denotes	activity
T4167	19182-19190	JJ	denotes	apparent
T4168	19191-19196	IN	denotes	under
T4169	19197-19200	DT	denotes	the
T4170	19201-19205	NN	denotes	skin
T4171	19206-19207	-LRB-	denotes	(
T4172	19207-19213	NN	denotes	Figure
T4173	19214-19216	CD	denotes	2D
T4174	19216-19217	-RRB-	denotes	)
T4175	19217-19218	.	denotes	.
T4176	19218-19387	sentence	denotes	At this stage, melanoblast migration from the neural crest is mostly complete, but there is a dorsoventral gradient in melanocyte differentiation and pigment synthesis.
T4177	19219-19221	IN	denotes	At
T4178	19278-19280	VBZ	denotes	is
T4179	19222-19226	DT	denotes	this
T4180	19227-19232	NN	denotes	stage
T4181	19232-19234	,	denotes	,
T4182	19234-19245	NN	denotes	melanoblast
T4183	19246-19255	NN	denotes	migration
T4184	19256-19260	IN	denotes	from
T4185	19261-19264	DT	denotes	the
T4186	19272-19277	NN	denotes	crest
T4187	19265-19271	JJ	denotes	neural
T4188	19281-19287	RB	denotes	mostly
T4189	19288-19296	JJ	denotes	complete
T4190	19296-19298	,	denotes	,
T4191	19298-19301	CC	denotes	but
T4192	19302-19307	EX	denotes	there
T4193	19308-19310	VBZ	denotes	is
T4194	19311-19312	DT	denotes	a
T4195	19326-19334	NN	denotes	gradient
T4196	19313-19325	JJ	denotes	dorsoventral
T4197	19335-19337	IN	denotes	in
T4198	19338-19348	NN	denotes	melanocyte
T4199	19349-19364	NN	denotes	differentiation
T4200	19365-19368	CC	denotes	and
T4201	19369-19376	NN	denotes	pigment
T4202	19377-19386	NN	denotes	synthesis
T4203	19386-19387	.	denotes	.
T4204	19387-19644	sentence	denotes	The skin of ae/ae neonates appears uniformly dark over the entire dorsum, but in ae/ae; deH/deH neonates, the area of dark skin is more restricted, particularly above the limbs, and resembles the pattern of dorsal eumelanin in at/at; deH/deH adult animals.
T4205	19388-19391	DT	denotes	The
T4206	19392-19396	NN	denotes	skin
T4207	19415-19422	VBZ	denotes	appears
T4208	19397-19399	IN	denotes	of
T4209	19400-19402	NN	denotes	ae
T4210	19403-19405	NN	denotes	ae
T4211	19402-19403	HYPH	denotes	/
T4212	19406-19414	NNS	denotes	neonates
T4213	19423-19432	RB	denotes	uniformly
T4214	19433-19437	JJ	denotes	dark
T4215	19438-19442	IN	denotes	over
T4216	19443-19446	DT	denotes	the
T4217	19454-19460	NN	denotes	dorsum
T4218	19447-19453	JJ	denotes	entire
T4219	19460-19462	,	denotes	,
T4220	19462-19465	CC	denotes	but
T4221	19466-19468	IN	denotes	in
T4222	19516-19518	VBZ	denotes	is
T4223	19469-19471	NN	denotes	ae
T4224	19472-19474	NN	denotes	ae
T4225	19471-19472	HYPH	denotes	/
T4226	19484-19492	NNS	denotes	neonates
T4227	19474-19475	:	denotes	;
T4228	19476-19479	NN	denotes	deH
T4229	19480-19483	NN	denotes	deH
T4230	19479-19480	HYPH	denotes	/
T4231	19492-19494	,	denotes	,
T4232	19494-19497	DT	denotes	the
T4233	19498-19502	NN	denotes	area
T4234	19503-19505	IN	denotes	of
T4235	19506-19510	JJ	denotes	dark
T4236	19511-19515	NN	denotes	skin
T4237	19519-19523	RBR	denotes	more
T4238	19524-19534	JJ	denotes	restricted
T4239	19534-19536	,	denotes	,
T4240	19536-19548	RB	denotes	particularly
T4241	19549-19554	IN	denotes	above
T4242	19555-19558	DT	denotes	the
T4243	19559-19564	NNS	denotes	limbs
T4244	19564-19566	,	denotes	,
T4245	19566-19569	CC	denotes	and
T4246	19570-19579	VBZ	denotes	resembles
T4247	19580-19583	DT	denotes	the
T4248	19584-19591	NN	denotes	pattern
T4249	19592-19594	IN	denotes	of
T4250	19595-19601	JJ	denotes	dorsal
T4251	19602-19611	NN	denotes	eumelanin
T4252	19612-19614	IN	denotes	in
T4253	19615-19617	NN	denotes	at
T4254	19618-19620	NN	denotes	at
T4255	19617-19618	HYPH	denotes	/
T4256	19636-19643	NNS	denotes	animals
T4257	19620-19621	,	denotes	;
T4258	19622-19625	NN	denotes	deH
T4259	19626-19629	NN	denotes	deH
T4260	19625-19626	HYPH	denotes	/
T4261	19630-19635	JJ	denotes	adult
T4262	19643-19644	.	denotes	.
T4263	19644-19863	sentence	denotes	Taken together, these observations suggest that deH interferes with the establishment of dorsoventral patterning during skin development by causing dorsal expansion of a lateral region that is normally 3–5 mm in width.
T4264	19645-19650	VBN	denotes	Taken
T4265	19680-19687	VBP	denotes	suggest
T4266	19651-19659	RB	denotes	together
T4267	19659-19661	,	denotes	,
T4268	19661-19666	DT	denotes	these
T4269	19667-19679	NNS	denotes	observations
T4270	19688-19692	IN	denotes	that
T4271	19697-19707	VBZ	denotes	interferes
T4272	19693-19696	NN	denotes	deH
T4273	19708-19712	IN	denotes	with
T4274	19713-19716	DT	denotes	the
T4275	19717-19730	NN	denotes	establishment
T4276	19731-19733	IN	denotes	of
T4277	19734-19746	JJ	denotes	dorsoventral
T4278	19747-19757	NN	denotes	patterning
T4279	19758-19764	IN	denotes	during
T4280	19765-19769	NN	denotes	skin
T4281	19770-19781	NN	denotes	development
T4282	19782-19784	IN	denotes	by
T4283	19785-19792	VBG	denotes	causing
T4284	19793-19799	JJ	denotes	dorsal
T4285	19800-19809	NN	denotes	expansion
T4286	19810-19812	IN	denotes	of
T4287	19813-19814	DT	denotes	a
T4288	19823-19829	NN	denotes	region
T4289	19815-19822	JJ	denotes	lateral
T4290	19830-19834	WDT	denotes	that
T4291	19835-19837	VBZ	denotes	is
T4292	19838-19846	RB	denotes	normally
T4293	19847-19848	CD	denotes	3
T4294	19849-19850	CD	denotes	5
T4295	19848-19849	SYM	denotes	–
T4296	19851-19853	NN	denotes	mm
T4297	19854-19856	IN	denotes	in
T4298	19857-19862	NN	denotes	width
T4299	19862-19863	.	denotes	.
T4300	19863-20094	sentence	denotes	This same region may serve as a boundary between dorsal and ventral skin by inhibiting melanocyte differentiation, by promoting pheomelanin synthesis, and by supporting a progressive increase in hair growth from ventrum to dorsum.
T4301	19864-19868	DT	denotes	This
T4302	19874-19880	NN	denotes	region
T4303	19869-19873	JJ	denotes	same
T4304	19885-19890	VB	denotes	serve
T4305	19881-19884	MD	denotes	may
T4306	19891-19893	IN	denotes	as
T4307	19894-19895	DT	denotes	a
T4308	19896-19904	NN	denotes	boundary
T4309	19905-19912	IN	denotes	between
T4310	19913-19919	JJ	denotes	dorsal
T4311	19932-19936	NN	denotes	skin
T4312	19920-19923	CC	denotes	and
T4313	19924-19931	JJ	denotes	ventral
T4314	19937-19939	IN	denotes	by
T4315	19940-19950	VBG	denotes	inhibiting
T4316	19951-19961	NN	denotes	melanocyte
T4317	19962-19977	NN	denotes	differentiation
T4318	19977-19979	,	denotes	,
T4319	19979-19981	IN	denotes	by
T4320	19982-19991	VBG	denotes	promoting
T4321	19992-20003	NN	denotes	pheomelanin
T4322	20004-20013	NN	denotes	synthesis
T4323	20013-20015	,	denotes	,
T4324	20015-20018	CC	denotes	and
T4325	20019-20021	IN	denotes	by
T4326	20022-20032	VBG	denotes	supporting
T4327	20033-20034	DT	denotes	a
T4328	20047-20055	NN	denotes	increase
T4329	20035-20046	JJ	denotes	progressive
T4330	20056-20058	IN	denotes	in
T4331	20059-20063	NN	denotes	hair
T4332	20064-20070	NN	denotes	growth
T4333	20071-20075	IN	denotes	from
T4334	20076-20083	NN	denotes	ventrum
T4335	20084-20086	IN	denotes	to
T4336	20087-20093	NN	denotes	dorsum
T4337	20093-20094	.	denotes	.
T4338	20094-20296	sentence	denotes	As described below, the gene defective in deH, Tbx15, is normally expressed in the dorsal region and therefore is likely to play a role in establishing the size and dorsal extent of the lateral region.
T4339	20095-20097	IN	denotes	As
T4340	20098-20107	VBN	denotes	described
T4341	20161-20170	VBN	denotes	expressed
T4342	20108-20113	RB	denotes	below
T4343	20113-20115	,	denotes	,
T4344	20115-20118	DT	denotes	the
T4345	20119-20123	NN	denotes	gene
T4346	20124-20133	JJ	denotes	defective
T4347	20134-20136	IN	denotes	in
T4348	20137-20140	NN	denotes	deH
T4349	20140-20142	,	denotes	,
T4350	20142-20147	NN	denotes	Tbx15
T4351	20147-20149	,	denotes	,
T4352	20149-20151	VBZ	denotes	is
T4353	20152-20160	RB	denotes	normally
T4354	20171-20173	IN	denotes	in
T4355	20174-20177	DT	denotes	the
T4356	20185-20191	NN	denotes	region
T4357	20178-20184	JJ	denotes	dorsal
T4358	20192-20195	CC	denotes	and
T4359	20196-20205	RB	denotes	therefore
T4360	20206-20208	VBZ	denotes	is
T4361	20209-20215	JJ	denotes	likely
T4362	20216-20218	TO	denotes	to
T4363	20219-20223	VB	denotes	play
T4364	20224-20225	DT	denotes	a
T4365	20226-20230	NN	denotes	role
T4366	20231-20233	IN	denotes	in
T4367	20234-20246	VBG	denotes	establishing
T4368	20247-20250	DT	denotes	the
T4369	20251-20255	NN	denotes	size
T4370	20256-20259	CC	denotes	and
T4371	20260-20266	JJ	denotes	dorsal
T4372	20267-20273	NN	denotes	extent
T4373	20274-20276	IN	denotes	of
T4374	20277-20280	DT	denotes	the
T4375	20289-20295	NN	denotes	region
T4376	20281-20288	JJ	denotes	lateral
T4377	20295-20296	.	denotes	.
T4613	20298-20308	JJ	denotes	Positional
T4614	20309-20316	NN	denotes	Cloning
T4615	20317-20319	IN	denotes	of
T4616	20320-20323	NN	denotes	deH
T4617	20323-20609	sentence	denotes	As a visible marker, early linkage studies with the original droopy ear allele or the deH allele identified a map position in the middle of Chromosome 3, distal to matted and proximal to Varitint-waddler (Carter and Falconer 1951; Curry 1959; Lane and Eicher 1979; Holmes et al. 1981).
T4618	20324-20326	IN	denotes	As
T4619	20421-20431	VBD	denotes	identified
T4620	20327-20328	DT	denotes	a
T4621	20337-20343	NN	denotes	marker
T4622	20329-20336	JJ	denotes	visible
T4623	20343-20345	,	denotes	,
T4624	20345-20350	JJ	denotes	early
T4625	20359-20366	NNS	denotes	studies
T4626	20351-20358	NN	denotes	linkage
T4627	20367-20371	IN	denotes	with
T4628	20372-20375	DT	denotes	the
T4629	20396-20402	NN	denotes	allele
T4630	20376-20384	JJ	denotes	original
T4631	20385-20391	JJ	denotes	droopy
T4632	20392-20395	NN	denotes	ear
T4633	20403-20405	CC	denotes	or
T4634	20406-20409	DT	denotes	the
T4635	20414-20420	NN	denotes	allele
T4636	20410-20413	NN	denotes	deH
T4637	20432-20433	DT	denotes	a
T4638	20438-20446	NN	denotes	position
T4639	20434-20437	NN	denotes	map
T4640	20447-20449	IN	denotes	in
T4641	20450-20453	DT	denotes	the
T4642	20454-20460	NN	denotes	middle
T4643	20461-20463	IN	denotes	of
T4644	20464-20474	NN	denotes	Chromosome
T4645	20475-20476	CD	denotes	3
T4646	20476-20478	,	denotes	,
T4647	20478-20484	JJ	denotes	distal
T4648	20485-20487	IN	denotes	to
T4649	20488-20494	JJ	denotes	matted
T4650	20495-20498	CC	denotes	and
T4651	20499-20507	JJ	denotes	proximal
T4652	20508-20510	IN	denotes	to
T4653	20511-20519	NNP	denotes	Varitint
T4654	20520-20527	NNP	denotes	waddler
T4655	20519-20520	HYPH	denotes	-
T4656	20528-20529	-LRB-	denotes	(
T4657	20529-20535	NNP	denotes	Carter
T4658	20536-20539	CC	denotes	and
T4659	20540-20548	NNP	denotes	Falconer
T4660	20549-20553	CD	denotes	1951
T4661	20553-20554	:	denotes	;
T4662	20555-20560	NNP	denotes	Curry
T4663	20561-20565	CD	denotes	1959
T4664	20565-20566	:	denotes	;
T4665	20567-20571	NNP	denotes	Lane
T4666	20572-20575	CC	denotes	and
T4667	20576-20582	NNP	denotes	Eicher
T4668	20583-20587	CD	denotes	1979
T4669	20587-20588	:	denotes	;
T4670	20589-20595	NNP	denotes	Holmes
T4671	20596-20598	FW	denotes	et
T4672	20599-20602	FW	denotes	al.
T4673	20603-20607	CD	denotes	1981
T4674	20607-20608	-RRB-	denotes	)
T4675	20608-20609	.	denotes	.
T4676	20609-20908	sentence	denotes	We used an F2 intercross with CAST/Ei mice to localize deH to a 0.1 cM interval between D3Mit213 and 16.MMHAP32FLF1, which was refined by development of a bacterial artificial chromosome (BAC) contig and additional markers to a 1.4 Mb region that contained eight genes, including Tbx15 (Figure 3A).
T4677	20610-20612	PRP	denotes	We
T4678	20613-20617	VBD	denotes	used
T4679	20618-20620	DT	denotes	an
T4680	20624-20634	NN	denotes	intercross
T4681	20621-20623	NN	denotes	F2
T4682	20635-20639	IN	denotes	with
T4683	20640-20644	NN	denotes	CAST
T4684	20645-20647	NN	denotes	Ei
T4685	20644-20645	HYPH	denotes	/
T4686	20648-20652	NNS	denotes	mice
T4687	20653-20655	TO	denotes	to
T4688	20656-20664	VB	denotes	localize
T4689	20665-20668	NN	denotes	deH
T4690	20669-20671	IN	denotes	to
T4691	20672-20673	DT	denotes	a
T4692	20681-20689	NN	denotes	interval
T4693	20674-20677	CD	denotes	0.1
T4694	20678-20680	NN	denotes	cM
T4695	20690-20697	IN	denotes	between
T4696	20698-20706	NN	denotes	D3Mit213
T4697	20707-20710	CC	denotes	and
T4698	20711-20725	NN	denotes	16.MMHAP32FLF1
T4699	20725-20727	,	denotes	,
T4700	20727-20732	WDT	denotes	which
T4701	20737-20744	VBN	denotes	refined
T4702	20733-20736	VBD	denotes	was
T4703	20745-20747	IN	denotes	by
T4704	20748-20759	NN	denotes	development
T4705	20760-20762	IN	denotes	of
T4706	20763-20764	DT	denotes	a
T4707	20803-20809	NN	denotes	contig
T4708	20765-20774	JJ	denotes	bacterial
T4709	20786-20796	NN	denotes	chromosome
T4710	20775-20785	JJ	denotes	artificial
T4711	20797-20798	-LRB-	denotes	(
T4712	20798-20801	NN	denotes	BAC
T4713	20801-20802	-RRB-	denotes	)
T4714	20810-20813	CC	denotes	and
T4715	20814-20824	JJ	denotes	additional
T4716	20825-20832	NNS	denotes	markers
T4717	20833-20835	IN	denotes	to
T4718	20836-20837	DT	denotes	a
T4719	20845-20851	NN	denotes	region
T4720	20838-20841	CD	denotes	1.4
T4721	20842-20844	NN	denotes	Mb
T4722	20852-20856	WDT	denotes	that
T4723	20857-20866	VBD	denotes	contained
T4724	20867-20872	CD	denotes	eight
T4725	20873-20878	NNS	denotes	genes
T4726	20878-20880	,	denotes	,
T4727	20880-20889	VBG	denotes	including
T4728	20890-20895	NN	denotes	Tbx15
T4729	20896-20897	-LRB-	denotes	(
T4730	20897-20903	NN	denotes	Figure
T4731	20904-20906	CD	denotes	3A
T4732	20906-20907	-RRB-	denotes	)
T4733	20907-20908	.	denotes	.
T4734	20908-21131	sentence	denotes	We considered Tbx15 as an excellent candidate for the skeletal abnormalities caused by deH, based on studies by Agulnik et al. (1998), who described its embryonic expression in the craniofacial region and developing limbs.
T4735	20909-20911	PRP	denotes	We
T4736	20912-20922	VBD	denotes	considered
T4737	20923-20928	NN	denotes	Tbx15
T4738	20929-20931	IN	denotes	as
T4739	20932-20934	DT	denotes	an
T4740	20945-20954	NN	denotes	candidate
T4741	20935-20944	JJ	denotes	excellent
T4742	20955-20958	IN	denotes	for
T4743	20959-20962	DT	denotes	the
T4744	20972-20985	NNS	denotes	abnormalities
T4745	20963-20971	JJ	denotes	skeletal
T4746	20986-20992	VBN	denotes	caused
T4747	20993-20995	IN	denotes	by
T4748	20996-20999	NN	denotes	deH
T4749	20999-21001	,	denotes	,
T4750	21001-21006	VBN	denotes	based
T4751	21007-21009	IN	denotes	on
T4752	21010-21017	NNS	denotes	studies
T4753	21018-21020	IN	denotes	by
T4754	21021-21028	NNP	denotes	Agulnik
T4755	21029-21031	FW	denotes	et
T4756	21032-21035	FW	denotes	al.
T4757	21036-21037	-LRB-	denotes	(
T4758	21037-21041	CD	denotes	1998
T4759	21041-21042	-RRB-	denotes	)
T4760	21042-21044	,	denotes	,
T4761	21044-21047	WP	denotes	who
T4762	21048-21057	VBD	denotes	described
T4763	21058-21061	PRP$	denotes	its
T4764	21072-21082	NN	denotes	expression
T4765	21062-21071	JJ	denotes	embryonic
T4766	21083-21085	IN	denotes	in
T4767	21086-21089	DT	denotes	the
T4768	21103-21109	NN	denotes	region
T4769	21090-21102	JJ	denotes	craniofacial
T4770	21110-21113	CC	denotes	and
T4771	21114-21124	VBG	denotes	developing
T4772	21125-21130	NNS	denotes	limbs
T4773	21130-21131	.	denotes	.
T4774	21131-22266	sentence	denotes	Figure 3 Molecular Genetics of deH and Tbx15 (A) Genetic and physical map, as described in the text. Markers M1 to M3 are SSCP markers generated from a BAC contig of the region; marker M4 is STS 16.MMHAP32FLF1 and was also used as an SSCP marker. M2 and M3, which flank the Tbx15 and M6pr-ps on the UCSC genome browser map and lie 634 kb apart, were nonrecombinant with deH in 2340 meioses. (B) The deH mutation is a deletion that starts in Tbx15 intron 1 and ends in the M6pr-ps. (C) Sequence of deletion breakpoints. (D) Diagram of Tbx15LacZ allele constructed by gene targeting. As described in the text, this allele is predicted to give rise to a protein truncated after approximately 154 codons and is lacking critical residues of the T box. Heterozygotes for the targeted allele exhibit normal size, morphology, and hair-color patterns, but homozygotes and Tbx15LacZ/deH compound heterozygotes are identical to deH homozygotes. Using sequence information from Agulnik et al. (1998) and the partially completed mouse genome sequence, we found that portions of several Tbx15 exons could not be amplified from deH/deH genomic DNA.
T4775	22067-22072	VBG	denotes	Using
T4776	22175-22180	VBD	denotes	found
T4777	22073-22081	NN	denotes	sequence
T4778	22082-22093	NN	denotes	information
T4779	22094-22098	IN	denotes	from
T4780	22099-22106	NNP	denotes	Agulnik
T4781	22107-22109	FW	denotes	et
T4782	22110-22113	FW	denotes	al.
T4783	22114-22115	-LRB-	denotes	(
T4784	22115-22119	CD	denotes	1998
T4785	22119-22120	-RRB-	denotes	)
T4786	22121-22124	CC	denotes	and
T4787	22125-22128	DT	denotes	the
T4788	22162-22170	NN	denotes	sequence
T4789	22129-22138	RB	denotes	partially
T4790	22139-22148	VBN	denotes	completed
T4791	22149-22154	NN	denotes	mouse
T4792	22155-22161	NN	denotes	genome
T4793	22170-22172	,	denotes	,
T4794	22172-22174	PRP	denotes	we
T4795	22181-22185	IN	denotes	that
T4796	22231-22240	VBN	denotes	amplified
T4797	22186-22194	NNS	denotes	portions
T4798	22195-22197	IN	denotes	of
T4799	22198-22205	JJ	denotes	several
T4800	22212-22217	NNS	denotes	exons
T4801	22206-22211	NN	denotes	Tbx15
T4802	22218-22223	MD	denotes	could
T4803	22224-22227	RB	denotes	not
T4804	22228-22230	VB	denotes	be
T4805	22241-22245	IN	denotes	from
T4806	22246-22249	NN	denotes	deH
T4807	22250-22253	NN	denotes	deH
T4808	22249-22250	HYPH	denotes	/
T4809	22262-22265	NN	denotes	DNA
T4810	22254-22261	JJ	denotes	genomic
T4811	22265-22266	.	denotes	.
T4812	22266-22479	sentence	denotes	The same gene was initially referred to as Tbx8 (Wattler et al. 1998) and then later renamed Tbx14, but is currently referred to in several vertebrate genomes as Tbx15 (Agulnik et al. 1998; Begemann et al. 2002).
T4813	22267-22270	DT	denotes	The
T4814	22276-22280	NN	denotes	gene
T4815	22271-22275	JJ	denotes	same
T4816	22295-22303	VBN	denotes	referred
T4817	22281-22284	VBD	denotes	was
T4818	22285-22294	RB	denotes	initially
T4819	22304-22306	IN	denotes	to
T4820	22307-22309	IN	denotes	as
T4821	22310-22314	NN	denotes	Tbx8
T4822	22315-22316	-LRB-	denotes	(
T4823	22316-22323	NNP	denotes	Wattler
T4824	22324-22326	FW	denotes	et
T4825	22327-22330	FW	denotes	al.
T4826	22331-22335	CD	denotes	1998
T4827	22335-22336	-RRB-	denotes	)
T4828	22337-22340	CC	denotes	and
T4829	22341-22345	RB	denotes	then
T4830	22352-22359	VBN	denotes	renamed
T4831	22346-22351	RB	denotes	later
T4832	22360-22365	NN	denotes	Tbx14
T4833	22365-22367	,	denotes	,
T4834	22367-22370	CC	denotes	but
T4835	22371-22373	VBZ	denotes	is
T4836	22384-22392	VBN	denotes	referred
T4837	22374-22383	RB	denotes	currently
T4838	22393-22395	IN	denotes	to
T4839	22396-22398	IN	denotes	in
T4840	22399-22406	JJ	denotes	several
T4841	22418-22425	NNS	denotes	genomes
T4842	22407-22417	NN	denotes	vertebrate
T4843	22426-22428	IN	denotes	as
T4844	22429-22434	NN	denotes	Tbx15
T4845	22435-22436	-LRB-	denotes	(
T4846	22436-22443	NNP	denotes	Agulnik
T4847	22444-22446	FW	denotes	et
T4848	22447-22450	FW	denotes	al.
T4849	22451-22455	CD	denotes	1998
T4850	22455-22456	:	denotes	;
T4851	22457-22465	NNP	denotes	Begemann
T4852	22466-22468	FW	denotes	et
T4853	22469-22472	FW	denotes	al.
T4854	22473-22477	CD	denotes	2002
T4855	22477-22478	-RRB-	denotes	)
T4856	22478-22479	.	denotes	.
T4857	22479-22829	sentence	denotes	By comparing the sequence of a 1.3 kb junction fragment amplified from deH/deH genomic DNA to publicly available mouse genome sequence, we identified a 216 kb deletion that extends from Tbx15 intron 1 to 148 kb downstream of the polyadenylation sequence in a region annotated as a mannose-6-phosphate receptor pseudogene, M6pr-ps (Figure 3B and 3C).
T4858	22480-22482	IN	denotes	By
T4859	22619-22629	VBD	denotes	identified
T4860	22483-22492	VBG	denotes	comparing
T4861	22493-22496	DT	denotes	the
T4862	22497-22505	NN	denotes	sequence
T4863	22506-22508	IN	denotes	of
T4864	22509-22510	DT	denotes	a
T4865	22527-22535	NN	denotes	fragment
T4866	22511-22514	CD	denotes	1.3
T4867	22515-22517	NN	denotes	kb
T4868	22518-22526	NN	denotes	junction
T4869	22536-22545	VBN	denotes	amplified
T4870	22546-22550	IN	denotes	from
T4871	22551-22554	NN	denotes	deH
T4872	22555-22558	NN	denotes	deH
T4873	22554-22555	HYPH	denotes	/
T4874	22567-22570	NN	denotes	DNA
T4875	22559-22566	JJ	denotes	genomic
T4876	22571-22573	IN	denotes	to
T4877	22574-22582	RB	denotes	publicly
T4878	22583-22592	JJ	denotes	available
T4879	22606-22614	NN	denotes	sequence
T4880	22593-22598	NN	denotes	mouse
T4881	22599-22605	NN	denotes	genome
T4882	22614-22616	,	denotes	,
T4883	22616-22618	PRP	denotes	we
T4884	22630-22631	DT	denotes	a
T4885	22639-22647	NN	denotes	deletion
T4886	22632-22635	CD	denotes	216
T4887	22636-22638	NN	denotes	kb
T4888	22648-22652	WDT	denotes	that
T4889	22653-22660	VBZ	denotes	extends
T4890	22661-22665	IN	denotes	from
T4891	22666-22671	NN	denotes	Tbx15
T4892	22672-22678	NN	denotes	intron
T4893	22679-22680	CD	denotes	1
T4894	22681-22683	IN	denotes	to
T4895	22684-22687	CD	denotes	148
T4896	22688-22690	NN	denotes	kb
T4897	22691-22701	RB	denotes	downstream
T4898	22702-22704	IN	denotes	of
T4899	22705-22708	DT	denotes	the
T4900	22725-22733	NN	denotes	sequence
T4901	22709-22724	NN	denotes	polyadenylation
T4902	22734-22736	IN	denotes	in
T4903	22737-22738	DT	denotes	a
T4904	22739-22745	NN	denotes	region
T4905	22746-22755	VBN	denotes	annotated
T4906	22756-22758	IN	denotes	as
T4907	22759-22760	DT	denotes	a
T4908	22790-22800	NN	denotes	pseudogene
T4909	22761-22768	NN	denotes	mannose
T4910	22771-22780	NN	denotes	phosphate
T4911	22768-22769	HYPH	denotes	-
T4912	22769-22770	CD	denotes	6
T4913	22770-22771	HYPH	denotes	-
T4914	22781-22789	NN	denotes	receptor
T4915	22800-22802	,	denotes	,
T4916	22802-22806	NN	denotes	M6pr
T4917	22807-22809	NN	denotes	ps
T4918	22806-22807	HYPH	denotes	-
T4919	22810-22811	-LRB-	denotes	(
T4920	22818-22820	CD	denotes	3B
T4921	22811-22817	NN	denotes	Figure
T4922	22821-22824	CC	denotes	and
T4923	22825-22827	CD	denotes	3C
T4924	22827-22828	-RRB-	denotes	)
T4925	22828-22829	.	denotes	.
T4926	22829-22851	sentence	denotes	(Ludwig et al. 1992).
T4927	22830-22831	-LRB-	denotes	(
T4928	22831-22837	NNP	denotes	Ludwig
T4929	22838-22840	FW	denotes	et
T4930	22841-22844	FW	denotes	al.
T4931	22845-22849	CD	denotes	1992
T4932	22849-22850	-RRB-	denotes	)
T4933	22850-22851	.	denotes	.
T4934	22851-22963	sentence	denotes	By Northern blot analysis, we identified a fusion transcript produced from the deH chromosome (data not shown).
T4935	22852-22854	IN	denotes	By
T4936	22882-22892	VBD	denotes	identified
T4937	22855-22863	NNP	denotes	Northern
T4938	22864-22868	NN	denotes	blot
T4939	22869-22877	NN	denotes	analysis
T4940	22877-22879	,	denotes	,
T4941	22879-22881	PRP	denotes	we
T4942	22893-22894	DT	denotes	a
T4943	22902-22912	NN	denotes	transcript
T4944	22895-22901	NN	denotes	fusion
T4945	22913-22921	VBN	denotes	produced
T4946	22922-22926	IN	denotes	from
T4947	22927-22930	DT	denotes	the
T4948	22935-22945	NN	denotes	chromosome
T4949	22931-22934	NN	denotes	deH
T4950	22946-22947	-LRB-	denotes	(
T4951	22956-22961	VBN	denotes	shown
T4952	22947-22951	NNS	denotes	data
T4953	22952-22955	RB	denotes	not
T4954	22961-22962	-RRB-	denotes	)
T4955	22962-22963	.	denotes	.
T4956	22963-23206	sentence	denotes	However, the deletion removes 534 of the 602 amino acids encoded by Tbx15 (including the T-box DNA-binding domain), deH/+ animals are grossly normal, and the phenotype of deH/deH animals is identical to that described for the original allele.
T4957	22964-22971	RB	denotes	However
T4958	22986-22993	VBZ	denotes	removes
T4959	22971-22973	,	denotes	,
T4960	22973-22976	DT	denotes	the
T4961	22977-22985	NN	denotes	deletion
T4962	22994-22997	CD	denotes	534
T4963	23005-23008	CD	denotes	602
T4964	22998-23000	IN	denotes	of
T4965	23001-23004	DT	denotes	the
T4966	23015-23020	NNS	denotes	acids
T4967	23009-23014	NN	denotes	amino
T4968	23021-23028	VBN	denotes	encoded
T4969	23029-23031	IN	denotes	by
T4970	23032-23037	NN	denotes	Tbx15
T4971	23038-23039	-LRB-	denotes	(
T4972	23039-23048	VBG	denotes	including
T4973	23049-23052	DT	denotes	the
T4974	23071-23077	NN	denotes	domain
T4975	23053-23054	NN	denotes	T
T4976	23055-23058	NN	denotes	box
T4977	23054-23055	HYPH	denotes	-
T4978	23059-23062	NN	denotes	DNA
T4979	23063-23070	VBG	denotes	binding
T4980	23062-23063	HYPH	denotes	-
T4981	23077-23078	-RRB-	denotes	)
T4982	23078-23080	,	denotes	,
T4983	23080-23083	NN	denotes	deH
T4984	23086-23093	NNS	denotes	animals
T4985	23083-23084	HYPH	denotes	/
T4986	23084-23085	SYM	denotes	+
T4987	23094-23097	VBP	denotes	are
T4988	23098-23105	RB	denotes	grossly
T4989	23106-23112	JJ	denotes	normal
T4990	23112-23114	,	denotes	,
T4991	23114-23117	CC	denotes	and
T4992	23118-23121	DT	denotes	the
T4993	23122-23131	NN	denotes	phenotype
T4994	23151-23153	VBZ	denotes	is
T4995	23132-23134	IN	denotes	of
T4996	23135-23138	NN	denotes	deH
T4997	23139-23142	NN	denotes	deH
T4998	23138-23139	HYPH	denotes	/
T4999	23143-23150	NNS	denotes	animals
T5000	23154-23163	JJ	denotes	identical
T5001	23164-23166	IN	denotes	to
T5002	23167-23171	DT	denotes	that
T5003	23172-23181	VBN	denotes	described
T5004	23182-23185	IN	denotes	for
T5005	23186-23189	DT	denotes	the
T5006	23199-23205	NN	denotes	allele
T5007	23190-23198	JJ	denotes	original
T5008	23205-23206	.	denotes	.
T5009	23206-23313	sentence	denotes	In addition, other than M6pr-ps, no other genes or transcripts have been annotated to the 216 kb deletion.
T5010	23207-23209	IN	denotes	In
T5011	23280-23289	VBN	denotes	annotated
T5012	23210-23218	NN	denotes	addition
T5013	23218-23220	,	denotes	,
T5014	23220-23225	JJ	denotes	other
T5015	23226-23230	IN	denotes	than
T5016	23231-23235	NN	denotes	M6pr
T5017	23236-23238	NN	denotes	ps
T5018	23235-23236	HYPH	denotes	-
T5019	23238-23240	,	denotes	,
T5020	23240-23242	DT	denotes	no
T5021	23249-23254	NNS	denotes	genes
T5022	23243-23248	JJ	denotes	other
T5023	23255-23257	CC	denotes	or
T5024	23258-23269	NNS	denotes	transcripts
T5025	23270-23274	VBP	denotes	have
T5026	23275-23279	VBN	denotes	been
T5027	23290-23292	IN	denotes	to
T5028	23293-23296	DT	denotes	the
T5029	23304-23312	NN	denotes	deletion
T5030	23297-23300	CD	denotes	216
T5031	23301-23303	NN	denotes	kb
T5032	23312-23313	.	denotes	.
T5033	23313-23467	sentence	denotes	While the positional cloning work was underway, one of us (A. Russ) generated an independent mutation of Tbx15 by gene targeting in embryonic stem cells.
T5034	23314-23319	IN	denotes	While
T5035	23348-23351	VBD	denotes	was
T5036	23320-23323	DT	denotes	the
T5037	23343-23347	NN	denotes	work
T5038	23324-23334	JJ	denotes	positional
T5039	23335-23342	NN	denotes	cloning
T5040	23382-23391	VBD	denotes	generated
T5041	23352-23360	RB	denotes	underway
T5042	23360-23362	,	denotes	,
T5043	23362-23365	CD	denotes	one
T5044	23366-23368	IN	denotes	of
T5045	23369-23371	PRP	denotes	us
T5046	23372-23373	-LRB-	denotes	(
T5047	23373-23375	NNP	denotes	A.
T5048	23376-23380	NNP	denotes	Russ
T5049	23380-23381	-RRB-	denotes	)
T5050	23392-23394	DT	denotes	an
T5051	23407-23415	NN	denotes	mutation
T5052	23395-23406	JJ	denotes	independent
T5053	23416-23418	IN	denotes	of
T5054	23419-23424	NN	denotes	Tbx15
T5055	23425-23427	IN	denotes	by
T5056	23428-23432	NN	denotes	gene
T5057	23433-23442	NN	denotes	targeting
T5058	23443-23445	IN	denotes	in
T5059	23446-23455	JJ	denotes	embryonic
T5060	23461-23466	NNS	denotes	cells
T5061	23456-23460	NN	denotes	stem
T5062	23466-23467	.	denotes	.
T5063	23467-23627	sentence	denotes	The targeted allele, Tbx15LacZ, carries an IRES-LacZ-neo cDNA cassette that disrupts the open reading frame at codon 154 early in the T-box domain (Figure 3D).
T5064	23468-23471	DT	denotes	The
T5065	23481-23487	NN	denotes	allele
T5066	23472-23480	VBN	denotes	targeted
T5067	23500-23507	VBZ	denotes	carries
T5068	23487-23489	,	denotes	,
T5069	23489-23498	NN	denotes	Tbx15LacZ
T5070	23498-23500	,	denotes	,
T5071	23508-23510	DT	denotes	an
T5072	23530-23538	NN	denotes	cassette
T5073	23511-23515	NN	denotes	IRES
T5074	23516-23520	NN	denotes	LacZ
T5075	23515-23516	HYPH	denotes	-
T5076	23520-23521	HYPH	denotes	-
T5077	23521-23524	JJ	denotes	neo
T5078	23525-23529	NN	denotes	cDNA
T5079	23539-23543	WDT	denotes	that
T5080	23544-23552	VBZ	denotes	disrupts
T5081	23553-23556	DT	denotes	the
T5082	23570-23575	NN	denotes	frame
T5083	23557-23561	JJ	denotes	open
T5084	23562-23569	NN	denotes	reading
T5085	23576-23578	IN	denotes	at
T5086	23579-23584	NN	denotes	codon
T5087	23585-23588	CD	denotes	154
T5088	23589-23594	RB	denotes	early
T5089	23595-23597	IN	denotes	in
T5090	23598-23601	DT	denotes	the
T5091	23608-23614	NN	denotes	domain
T5092	23602-23603	NN	denotes	T
T5093	23604-23607	NN	denotes	box
T5094	23603-23604	HYPH	denotes	-
T5095	23615-23616	-LRB-	denotes	(
T5096	23616-23622	NN	denotes	Figure
T5097	23623-23625	CD	denotes	3D
T5098	23625-23626	-RRB-	denotes	)
T5099	23626-23627	.	denotes	.
T5100	23627-23914	sentence	denotes	Animals heterozygous for the targeted allele are completely normal with regard to size, skeletal morphology, and hair-color distribution, but Tbx15LacZ/Tbx15LacZ homozygotes were noted to exhibit reduced body size and an abnormal craniofacial appearance identical to that caused by deH.
T5101	23628-23635	NNS	denotes	Animals
T5102	23673-23676	VBP	denotes	are
T5103	23636-23648	JJ	denotes	heterozygous
T5104	23649-23652	IN	denotes	for
T5105	23653-23656	DT	denotes	the
T5106	23666-23672	NN	denotes	allele
T5107	23657-23665	VBN	denotes	targeted
T5108	23677-23687	RB	denotes	completely
T5109	23688-23694	JJ	denotes	normal
T5110	23695-23699	IN	denotes	with
T5111	23700-23706	NN	denotes	regard
T5112	23707-23709	IN	denotes	to
T5113	23710-23714	NN	denotes	size
T5114	23714-23716	,	denotes	,
T5115	23716-23724	JJ	denotes	skeletal
T5116	23725-23735	NN	denotes	morphology
T5117	23735-23737	,	denotes	,
T5118	23737-23740	CC	denotes	and
T5119	23741-23745	NN	denotes	hair
T5120	23746-23751	NN	denotes	color
T5121	23745-23746	HYPH	denotes	-
T5122	23752-23764	NN	denotes	distribution
T5123	23764-23766	,	denotes	,
T5124	23766-23769	CC	denotes	but
T5125	23770-23779	NN	denotes	Tbx15LacZ
T5126	23780-23789	NN	denotes	Tbx15LacZ
T5127	23779-23780	HYPH	denotes	/
T5128	23790-23801	NNS	denotes	homozygotes
T5129	23807-23812	VBN	denotes	noted
T5130	23802-23806	VBD	denotes	were
T5131	23813-23815	TO	denotes	to
T5132	23816-23823	VB	denotes	exhibit
T5133	23824-23831	VBN	denotes	reduced
T5134	23837-23841	NN	denotes	size
T5135	23832-23836	NN	denotes	body
T5136	23842-23845	CC	denotes	and
T5137	23846-23848	DT	denotes	an
T5138	23871-23881	NN	denotes	appearance
T5139	23849-23857	JJ	denotes	abnormal
T5140	23858-23870	JJ	denotes	craniofacial
T5141	23882-23891	JJ	denotes	identical
T5142	23892-23894	IN	denotes	to
T5143	23895-23899	DT	denotes	that
T5144	23900-23906	VBN	denotes	caused
T5145	23907-23909	IN	denotes	by
T5146	23910-23913	NN	denotes	deH
T5147	23913-23914	.	denotes	.
T5148	23914-24160	sentence	denotes	We generated Tbx15LacZ/deH compound heterozygotes; on an Aw/at background, these animals exhibited the same abnormal restriction of dorsal pigmentation at P3.5 and expanded yellow flank area as described above for deH/deH animals (see Figure 2).
T5149	23915-23917	PRP	denotes	We
T5150	23918-23927	VBD	denotes	generated
T5151	24004-24013	VBD	denotes	exhibited
T5152	23928-23937	NN	denotes	Tbx15LacZ
T5153	23938-23941	NN	denotes	deH
T5154	23937-23938	SYM	denotes	/
T5155	23951-23964	NNS	denotes	heterozygotes
T5156	23942-23950	NN	denotes	compound
T5157	23964-23965	:	denotes	;
T5158	23966-23968	IN	denotes	on
T5159	23969-23971	DT	denotes	an
T5160	23978-23988	NN	denotes	background
T5161	23972-23974	NN	denotes	Aw
T5162	23975-23977	NN	denotes	at
T5163	23974-23975	HYPH	denotes	/
T5164	23988-23990	,	denotes	,
T5165	23990-23995	DT	denotes	these
T5166	23996-24003	NNS	denotes	animals
T5167	24014-24017	DT	denotes	the
T5168	24032-24043	NN	denotes	restriction
T5169	24018-24022	JJ	denotes	same
T5170	24023-24031	JJ	denotes	abnormal
T5171	24044-24046	IN	denotes	of
T5172	24047-24053	JJ	denotes	dorsal
T5173	24054-24066	NN	denotes	pigmentation
T5174	24067-24069	IN	denotes	at
T5175	24070-24074	NN	denotes	P3.5
T5176	24075-24078	CC	denotes	and
T5177	24079-24087	VBN	denotes	expanded
T5178	24101-24105	NN	denotes	area
T5179	24088-24094	JJ	denotes	yellow
T5180	24095-24100	NN	denotes	flank
T5181	24106-24108	IN	denotes	as
T5182	24109-24118	VBN	denotes	described
T5183	24119-24124	RB	denotes	above
T5184	24125-24128	IN	denotes	for
T5185	24129-24132	NN	denotes	deH
T5186	24133-24136	NN	denotes	deH
T5187	24132-24133	HYPH	denotes	/
T5188	24137-24144	NNS	denotes	animals
T5189	24145-24146	-LRB-	denotes	(
T5190	24146-24149	VB	denotes	see
T5191	24150-24156	NN	denotes	Figure
T5192	24157-24158	CD	denotes	2
T5193	24158-24159	-RRB-	denotes	)
T5194	24159-24160	.	denotes	.
T5195	24160-24293	sentence	denotes	These observations demonstrate that the pigmentary and craniofacial characteristics of deH are caused by loss of function for Tbx15.
T5196	24161-24166	DT	denotes	These
T5197	24167-24179	NNS	denotes	observations
T5198	24180-24191	VBP	denotes	demonstrate
T5199	24192-24196	IN	denotes	that
T5200	24256-24262	VBN	denotes	caused
T5201	24197-24200	DT	denotes	the
T5202	24229-24244	NNS	denotes	characteristics
T5203	24201-24211	JJ	denotes	pigmentary
T5204	24212-24215	CC	denotes	and
T5205	24216-24228	JJ	denotes	craniofacial
T5206	24245-24247	IN	denotes	of
T5207	24248-24251	NN	denotes	deH
T5208	24252-24255	VBP	denotes	are
T5209	24263-24265	IN	denotes	by
T5210	24266-24270	NN	denotes	loss
T5211	24271-24273	IN	denotes	of
T5212	24274-24282	NN	denotes	function
T5213	24283-24286	IN	denotes	for
T5214	24287-24292	NN	denotes	Tbx15
T5215	24292-24293	.	denotes	.
T5465	24295-24305	NN	denotes	Expression
T5466	24306-24308	IN	denotes	of
T5467	24309-24314	NN	denotes	Tbx15
T5468	24315-24318	CC	denotes	and
T5469	24319-24325	NN	denotes	Agouti
T5470	24325-24568	sentence	denotes	Previous studies by Agulnik et al. (1998) using whole-mount in situ hybridization described expression of Tbx15 as first detectable at E9.5 in the limb buds, progressing to the branchial arches, flanks, and craniofacial regions through E12.5.
T5471	24326-24334	JJ	denotes	Previous
T5472	24335-24342	NNS	denotes	studies
T5473	24408-24417	VBD	denotes	described
T5474	24343-24345	IN	denotes	by
T5475	24346-24353	NNP	denotes	Agulnik
T5476	24354-24356	FW	denotes	et
T5477	24357-24360	FW	denotes	al.
T5478	24361-24362	-LRB-	denotes	(
T5479	24362-24366	CD	denotes	1998
T5480	24366-24367	-RRB-	denotes	)
T5481	24368-24373	VBG	denotes	using
T5482	24374-24379	JJ	denotes	whole
T5483	24380-24385	NN	denotes	mount
T5484	24379-24380	HYPH	denotes	-
T5485	24394-24407	NN	denotes	hybridization
T5486	24386-24388	FW	denotes	in
T5487	24389-24393	FW	denotes	situ
T5488	24418-24428	NN	denotes	expression
T5489	24429-24431	IN	denotes	of
T5490	24432-24437	NN	denotes	Tbx15
T5491	24438-24440	IN	denotes	as
T5492	24441-24446	RB	denotes	first
T5493	24447-24457	JJ	denotes	detectable
T5494	24458-24460	IN	denotes	at
T5495	24461-24465	NN	denotes	E9.5
T5496	24466-24468	IN	denotes	in
T5497	24469-24472	DT	denotes	the
T5498	24478-24482	NNS	denotes	buds
T5499	24473-24477	NN	denotes	limb
T5500	24482-24484	,	denotes	,
T5501	24484-24495	VBG	denotes	progressing
T5502	24496-24498	IN	denotes	to
T5503	24499-24502	DT	denotes	the
T5504	24513-24519	NNS	denotes	arches
T5505	24503-24512	JJ	denotes	branchial
T5506	24519-24521	,	denotes	,
T5507	24521-24527	NNS	denotes	flanks
T5508	24527-24529	,	denotes	,
T5509	24529-24532	CC	denotes	and
T5510	24533-24545	JJ	denotes	craniofacial
T5511	24546-24553	NNS	denotes	regions
T5512	24554-24561	IN	denotes	through
T5513	24562-24567	NN	denotes	E12.5
T5514	24567-24568	.	denotes	.
T5515	24568-24945	sentence	denotes	To investigate this pattern in more detail, we hybridized a Tbx15 mRNA probe to a series of transverse sections at E12.5 and observed expression in multiple mesenchymal tissues of the head, trunk, and developing limbs (Figure 4A), much of which is consistent with the skull, cervical vertebrae, and limb malformations reported for mice carrying the original droopy ear allele.
T5516	24569-24571	TO	denotes	To
T5517	24572-24583	VB	denotes	investigate
T5518	24616-24626	VBD	denotes	hybridized
T5519	24584-24588	DT	denotes	this
T5520	24589-24596	NN	denotes	pattern
T5521	24597-24599	IN	denotes	in
T5522	24600-24604	JJR	denotes	more
T5523	24605-24611	NN	denotes	detail
T5524	24611-24613	,	denotes	,
T5525	24613-24615	PRP	denotes	we
T5526	24627-24628	DT	denotes	a
T5527	24640-24645	NN	denotes	probe
T5528	24629-24634	NN	denotes	Tbx15
T5529	24635-24639	NN	denotes	mRNA
T5530	24646-24648	IN	denotes	to
T5531	24649-24650	DT	denotes	a
T5532	24651-24657	NN	denotes	series
T5533	24658-24660	IN	denotes	of
T5534	24661-24671	JJ	denotes	transverse
T5535	24672-24680	NNS	denotes	sections
T5536	24681-24683	IN	denotes	at
T5537	24684-24689	NN	denotes	E12.5
T5538	24690-24693	CC	denotes	and
T5539	24694-24702	VBD	denotes	observed
T5540	24703-24713	NN	denotes	expression
T5541	24714-24716	IN	denotes	in
T5542	24717-24725	JJ	denotes	multiple
T5543	24738-24745	NNS	denotes	tissues
T5544	24726-24737	JJ	denotes	mesenchymal
T5545	24746-24748	IN	denotes	of
T5546	24749-24752	DT	denotes	the
T5547	24753-24757	NN	denotes	head
T5548	24757-24759	,	denotes	,
T5549	24759-24764	NN	denotes	trunk
T5550	24764-24766	,	denotes	,
T5551	24766-24769	CC	denotes	and
T5552	24770-24780	VBG	denotes	developing
T5553	24781-24786	NNS	denotes	limbs
T5554	24787-24788	-LRB-	denotes	(
T5555	24788-24794	NN	denotes	Figure
T5556	24795-24797	CD	denotes	4A
T5557	24797-24798	-RRB-	denotes	)
T5558	24798-24800	,	denotes	,
T5559	24800-24804	JJ	denotes	much
T5560	24814-24816	VBZ	denotes	is
T5561	24805-24807	IN	denotes	of
T5562	24808-24813	WDT	denotes	which
T5563	24817-24827	JJ	denotes	consistent
T5564	24828-24832	IN	denotes	with
T5565	24833-24836	DT	denotes	the
T5566	24873-24886	NNS	denotes	malformations
T5567	24837-24842	NN	denotes	skull
T5568	24842-24844	,	denotes	,
T5569	24844-24852	JJ	denotes	cervical
T5570	24853-24862	NNS	denotes	vertebrae
T5571	24862-24864	,	denotes	,
T5572	24864-24867	CC	denotes	and
T5573	24868-24872	NN	denotes	limb
T5574	24887-24895	VBN	denotes	reported
T5575	24896-24899	IN	denotes	for
T5576	24900-24904	NNS	denotes	mice
T5577	24905-24913	VBG	denotes	carrying
T5578	24914-24917	DT	denotes	the
T5579	24938-24944	NN	denotes	allele
T5580	24918-24926	JJ	denotes	original
T5581	24927-24933	JJ	denotes	droopy
T5582	24934-24937	NN	denotes	ear
T5583	24944-24945	.	denotes	.
T5584	24945-25896	sentence	denotes	Figure 4 Developmental Expression of Tbx15 (A) At E12.5, transverse sections at different levels show expression in head mesenchyme (a and b); myotome, occipital, and periocular mesenchyme (b); palatal shelf, cervical sclerotome, and nasal cartilage (c); maxillary and mandibular processes (d); limbs (e); and myotome and lateral mesenchyme (e and f) (scale bars = 500 μm). (B) Transverse sections through the flank at different times show expression in lateral mesenchyme (E11.5), expanding dorsally at E12.5, and both ventrally and dorsally at E13.5, detectable in loose mesenchyme underlying the dermis and the abdominal and subcutaneous muscles (scale bar = 500 μm). At P3.5, Tbx15 is expressed in the entire dermis and is most strongly expressed in dermal sheaths (scale bar = 200 μm). We were particularly interested in determining the exact nature of the embryonic flank expression relative to the ventralized phenotype of adult deH/deH mice.
T5585	25738-25740	PRP	denotes	We
T5586	25741-25745	VBD	denotes	were
T5587	25746-25758	RB	denotes	particularly
T5588	25759-25769	JJ	denotes	interested
T5589	25770-25772	IN	denotes	in
T5590	25773-25784	VBG	denotes	determining
T5591	25785-25788	DT	denotes	the
T5592	25795-25801	NN	denotes	nature
T5593	25789-25794	JJ	denotes	exact
T5594	25802-25804	IN	denotes	of
T5595	25805-25808	DT	denotes	the
T5596	25825-25835	NN	denotes	expression
T5597	25809-25818	JJ	denotes	embryonic
T5598	25819-25824	NN	denotes	flank
T5599	25836-25844	JJ	denotes	relative
T5600	25845-25847	IN	denotes	to
T5601	25848-25851	DT	denotes	the
T5602	25864-25873	NN	denotes	phenotype
T5603	25852-25863	VBN	denotes	ventralized
T5604	25874-25876	IN	denotes	of
T5605	25877-25882	JJ	denotes	adult
T5606	25891-25895	NNS	denotes	mice
T5607	25883-25886	NN	denotes	deH
T5608	25887-25890	NN	denotes	deH
T5609	25886-25887	SYM	denotes	/
T5610	25895-25896	.	denotes	.
T5611	25896-26128	sentence	denotes	Transverse abdominal sections from different times during development reveal a dorsolateral band of expression in the superficial mesenchyme at E11.5 that broadens both dorsally and ventrally over the next several days (Figure 4B).
T5612	25897-25907	JJ	denotes	Transverse
T5613	25918-25926	NNS	denotes	sections
T5614	25908-25917	JJ	denotes	abdominal
T5615	25967-25973	VBP	denotes	reveal
T5616	25927-25931	IN	denotes	from
T5617	25932-25941	JJ	denotes	different
T5618	25942-25947	NNS	denotes	times
T5619	25948-25954	IN	denotes	during
T5620	25955-25966	NN	denotes	development
T5621	25974-25975	DT	denotes	a
T5622	25989-25993	NN	denotes	band
T5623	25976-25988	JJ	denotes	dorsolateral
T5624	25994-25996	IN	denotes	of
T5625	25997-26007	NN	denotes	expression
T5626	26008-26010	IN	denotes	in
T5627	26011-26014	DT	denotes	the
T5628	26027-26037	NN	denotes	mesenchyme
T5629	26015-26026	JJ	denotes	superficial
T5630	26038-26040	IN	denotes	at
T5631	26041-26046	NN	denotes	E11.5
T5632	26047-26051	WDT	denotes	that
T5633	26052-26060	VBZ	denotes	broadens
T5634	26061-26065	CC	denotes	both
T5635	26066-26074	RB	denotes	dorsally
T5636	26075-26078	CC	denotes	and
T5637	26079-26088	RB	denotes	ventrally
T5638	26089-26093	IN	denotes	over
T5639	26094-26097	DT	denotes	the
T5640	26111-26115	NNS	denotes	days
T5641	26098-26102	JJ	denotes	next
T5642	26103-26110	JJ	denotes	several
T5643	26116-26117	-LRB-	denotes	(
T5644	26117-26123	NN	denotes	Figure
T5645	26124-26126	CD	denotes	4B
T5646	26126-26127	-RRB-	denotes	)
T5647	26127-26128	.	denotes	.
T5648	26128-26326	sentence	denotes	By E13.5, the developing dermis has become separated from the loose mesenchyme by a subcutaneous muscle layer; Tbx15 is expressed in all of these layers as well as the underlying abdominal muscles.
T5649	26129-26131	IN	denotes	By
T5650	26165-26171	VBN	denotes	become
T5651	26132-26137	NN	denotes	E13.5
T5652	26137-26139	,	denotes	,
T5653	26139-26142	DT	denotes	the
T5654	26154-26160	NN	denotes	dermis
T5655	26143-26153	VBG	denotes	developing
T5656	26161-26164	VBZ	denotes	has
T5657	26249-26258	VBN	denotes	expressed
T5658	26172-26181	JJ	denotes	separated
T5659	26182-26186	IN	denotes	from
T5660	26187-26190	DT	denotes	the
T5661	26197-26207	NN	denotes	mesenchyme
T5662	26191-26196	JJ	denotes	loose
T5663	26208-26210	IN	denotes	by
T5664	26211-26212	DT	denotes	a
T5665	26233-26238	NN	denotes	layer
T5666	26213-26225	JJ	denotes	subcutaneous
T5667	26226-26232	NN	denotes	muscle
T5668	26238-26239	:	denotes	;
T5669	26240-26245	NN	denotes	Tbx15
T5670	26246-26248	VBZ	denotes	is
T5671	26259-26261	IN	denotes	in
T5672	26262-26265	DT	denotes	all
T5673	26266-26268	IN	denotes	of
T5674	26269-26274	DT	denotes	these
T5675	26275-26281	NNS	denotes	layers
T5676	26282-26284	RB	denotes	as
T5677	26290-26292	IN	denotes	as
T5678	26285-26289	RB	denotes	well
T5679	26293-26296	DT	denotes	the
T5680	26318-26325	NNS	denotes	muscles
T5681	26297-26307	VBG	denotes	underlying
T5682	26308-26317	JJ	denotes	abdominal
T5683	26325-26326	.	denotes	.
T5684	26326-26566	sentence	denotes	In P3.5 skin, Tbx15 is expressed in both dorsal and ventral skin, most strongly in the condensed upper dermis and developing dermal sheaths of hair follicles; faint expression can also be detected in rare dermal papillae cells (Figure 4B).
T5685	26327-26329	IN	denotes	In
T5686	26350-26359	VBN	denotes	expressed
T5687	26330-26334	NN	denotes	P3.5
T5688	26335-26339	NN	denotes	skin
T5689	26339-26341	,	denotes	,
T5690	26341-26346	NN	denotes	Tbx15
T5691	26347-26349	VBZ	denotes	is
T5692	26515-26523	VBN	denotes	detected
T5693	26360-26362	IN	denotes	in
T5694	26363-26367	CC	denotes	both
T5695	26368-26374	JJ	denotes	dorsal
T5696	26387-26391	NN	denotes	skin
T5697	26375-26378	CC	denotes	and
T5698	26379-26386	JJ	denotes	ventral
T5699	26391-26393	,	denotes	,
T5700	26393-26397	RBS	denotes	most
T5701	26398-26406	RB	denotes	strongly
T5702	26407-26409	IN	denotes	in
T5703	26410-26413	DT	denotes	the
T5704	26430-26436	NN	denotes	dermis
T5705	26414-26423	VBN	denotes	condensed
T5706	26424-26429	JJ	denotes	upper
T5707	26437-26440	CC	denotes	and
T5708	26441-26451	VBG	denotes	developing
T5709	26459-26466	NNS	denotes	sheaths
T5710	26452-26458	JJ	denotes	dermal
T5711	26467-26469	IN	denotes	of
T5712	26470-26474	NN	denotes	hair
T5713	26475-26484	NNS	denotes	follicles
T5714	26484-26485	:	denotes	;
T5715	26486-26491	JJ	denotes	faint
T5716	26492-26502	NN	denotes	expression
T5717	26503-26506	MD	denotes	can
T5718	26507-26511	RB	denotes	also
T5719	26512-26514	VB	denotes	be
T5720	26524-26526	IN	denotes	in
T5721	26527-26531	JJ	denotes	rare
T5722	26548-26553	NNS	denotes	cells
T5723	26532-26538	JJ	denotes	dermal
T5724	26539-26547	NNS	denotes	papillae
T5725	26554-26555	-LRB-	denotes	(
T5726	26555-26561	NN	denotes	Figure
T5727	26562-26564	CD	denotes	4B
T5728	26564-26565	-RRB-	denotes	)
T5729	26565-26566	.	denotes	.
T5730	26566-26750	sentence	denotes	Although the effects of Agouti on pigment-type switching occur during postnatal hair growth, the ventral-specific isoform of Agouti is expressed in developing skin beginning at E11.5.
T5731	26567-26575	IN	denotes	Although
T5732	26624-26629	VBP	denotes	occur
T5733	26576-26579	DT	denotes	the
T5734	26580-26587	NNS	denotes	effects
T5735	26588-26590	IN	denotes	of
T5736	26591-26597	NN	denotes	Agouti
T5737	26598-26600	IN	denotes	on
T5738	26601-26608	NN	denotes	pigment
T5739	26609-26613	NN	denotes	type
T5740	26608-26609	HYPH	denotes	-
T5741	26614-26623	VBG	denotes	switching
T5742	26702-26711	VBN	denotes	expressed
T5743	26630-26636	IN	denotes	during
T5744	26637-26646	JJ	denotes	postnatal
T5745	26652-26658	NN	denotes	growth
T5746	26647-26651	NN	denotes	hair
T5747	26658-26660	,	denotes	,
T5748	26660-26663	DT	denotes	the
T5749	26681-26688	NN	denotes	isoform
T5750	26664-26671	JJ	denotes	ventral
T5751	26672-26680	JJ	denotes	specific
T5752	26671-26672	HYPH	denotes	-
T5753	26689-26691	IN	denotes	of
T5754	26692-26698	NN	denotes	Agouti
T5755	26699-26701	VBZ	denotes	is
T5756	26712-26714	IN	denotes	in
T5757	26715-26725	VBG	denotes	developing
T5758	26726-26730	NN	denotes	skin
T5759	26731-26740	VBG	denotes	beginning
T5760	26741-26743	IN	denotes	at
T5761	26744-26749	NN	denotes	E11.5
T5762	26749-26750	.	denotes	.
T5763	26750-26971	sentence	denotes	We compared adjacent sections hybridized with probes for Tbx15 and Agouti and observed complementary patterns at E12.5, with expression of Agouti in ventral skin and expression of Tbx15 in dorsal skin (Figure 5A and 5B).
T5764	26751-26753	PRP	denotes	We
T5765	26754-26762	VBD	denotes	compared
T5766	26763-26771	JJ	denotes	adjacent
T5767	26772-26780	NNS	denotes	sections
T5768	26781-26791	VBN	denotes	hybridized
T5769	26792-26796	IN	denotes	with
T5770	26797-26803	NNS	denotes	probes
T5771	26804-26807	IN	denotes	for
T5772	26808-26813	NN	denotes	Tbx15
T5773	26814-26817	CC	denotes	and
T5774	26818-26824	NN	denotes	Agouti
T5775	26825-26828	CC	denotes	and
T5776	26829-26837	VBD	denotes	observed
T5777	26838-26851	JJ	denotes	complementary
T5778	26852-26860	NNS	denotes	patterns
T5779	26861-26863	IN	denotes	at
T5780	26864-26869	NN	denotes	E12.5
T5781	26869-26871	,	denotes	,
T5782	26871-26875	IN	denotes	with
T5783	26876-26886	NN	denotes	expression
T5784	26887-26889	IN	denotes	of
T5785	26890-26896	NN	denotes	Agouti
T5786	26897-26899	IN	denotes	in
T5787	26900-26907	JJ	denotes	ventral
T5788	26908-26912	NN	denotes	skin
T5789	26913-26916	CC	denotes	and
T5790	26917-26927	NN	denotes	expression
T5791	26928-26930	IN	denotes	of
T5792	26931-26936	NN	denotes	Tbx15
T5793	26937-26939	IN	denotes	in
T5794	26940-26946	JJ	denotes	dorsal
T5795	26947-26951	NN	denotes	skin
T5796	26952-26953	-LRB-	denotes	(
T5797	26960-26962	CD	denotes	5A
T5798	26953-26959	NN	denotes	Figure
T5799	26963-26966	CC	denotes	and
T5800	26967-26969	CD	denotes	5B
T5801	26969-26970	-RRB-	denotes	)
T5802	26970-26971	.	denotes	.
T5803	26971-27143	sentence	denotes	The junction between expression domains is indistinct, and by E14.5, Tbx15 expression extends ventrally and overlaps extensively with Agouti expression (Figure 5C and 5D).
T5804	26972-26975	DT	denotes	The
T5805	26976-26984	NN	denotes	junction
T5806	27012-27014	VBZ	denotes	is
T5807	26985-26992	IN	denotes	between
T5808	26993-27003	NN	denotes	expression
T5809	27004-27011	NNS	denotes	domains
T5810	27015-27025	JJ	denotes	indistinct
T5811	27025-27027	,	denotes	,
T5812	27027-27030	CC	denotes	and
T5813	27031-27033	IN	denotes	by
T5814	27058-27065	VBZ	denotes	extends
T5815	27034-27039	NN	denotes	E14.5
T5816	27039-27041	,	denotes	,
T5817	27041-27046	NN	denotes	Tbx15
T5818	27047-27057	NN	denotes	expression
T5819	27066-27075	RB	denotes	ventrally
T5820	27076-27079	CC	denotes	and
T5821	27080-27088	VBZ	denotes	overlaps
T5822	27089-27100	RB	denotes	extensively
T5823	27101-27105	IN	denotes	with
T5824	27106-27112	NN	denotes	Agouti
T5825	27113-27123	NN	denotes	expression
T5826	27124-27125	-LRB-	denotes	(
T5827	27132-27134	CD	denotes	5C
T5828	27125-27131	NN	denotes	Figure
T5829	27135-27138	CC	denotes	and
T5830	27139-27141	CD	denotes	5D
T5831	27141-27142	-RRB-	denotes	)
T5832	27142-27143	.	denotes	.
T5833	27143-27798	sentence	denotes	Figure 5 Embryonic Expression of Tbx15 Compared to Agouti in at/at Mice (A and C) Tbx15. (B and D) Agouti. At E12.5, expression of Tbx15 in dorsal skin is approximately complementary to that of Agouti in ventral skin. At E14.5, the levels of expression for both genes are lower, but Tbx15 expression has expanded ventrally and overlaps extensively with that of Agouti. In all four panels, arrows mark the approximate ventral limit of Tbx15 and the approximate dorsal limit of Agouti (scale bars = 500 μm). We also examined the effect of deH on expression of Agouti and found no difference between mutant and nonmutant at E12.5 or E13.5 (data not shown).
T5834	27651-27653	PRP	denotes	We
T5835	27659-27667	VBD	denotes	examined
T5836	27654-27658	RB	denotes	also
T5837	27668-27671	DT	denotes	the
T5838	27672-27678	NN	denotes	effect
T5839	27679-27681	IN	denotes	of
T5840	27682-27685	NN	denotes	deH
T5841	27686-27688	IN	denotes	on
T5842	27689-27699	NN	denotes	expression
T5843	27700-27702	IN	denotes	of
T5844	27703-27709	NN	denotes	Agouti
T5845	27710-27713	CC	denotes	and
T5846	27714-27719	VBD	denotes	found
T5847	27720-27722	DT	denotes	no
T5848	27723-27733	NN	denotes	difference
T5849	27734-27741	IN	denotes	between
T5850	27742-27748	JJ	denotes	mutant
T5851	27749-27752	CC	denotes	and
T5852	27753-27762	JJ	denotes	nonmutant
T5853	27763-27765	IN	denotes	at
T5854	27766-27771	NN	denotes	E12.5
T5855	27772-27774	CC	denotes	or
T5856	27775-27780	NN	denotes	E13.5
T5857	27781-27782	-LRB-	denotes	(
T5858	27791-27796	VBN	denotes	shown
T5859	27782-27786	NNS	denotes	data
T5860	27787-27790	RB	denotes	not
T5861	27796-27797	-RRB-	denotes	)
T5862	27797-27798	.	denotes	.
T5863	27798-27941	sentence	denotes	However, at E14.5, the normal ventral-to-dorsal gradient of Agouti expression appeared to extend more dorsally in deH/deH embryos (Figure 6A).
T5864	27799-27806	RB	denotes	However
T5865	27877-27885	VBD	denotes	appeared
T5866	27806-27808	,	denotes	,
T5867	27808-27810	IN	denotes	at
T5868	27811-27816	NN	denotes	E14.5
T5869	27816-27818	,	denotes	,
T5870	27818-27821	DT	denotes	the
T5871	27847-27855	NN	denotes	gradient
T5872	27822-27828	JJ	denotes	normal
T5873	27829-27836	JJ	denotes	ventral
T5874	27836-27837	HYPH	denotes	-
T5875	27837-27839	IN	denotes	to
T5876	27839-27840	HYPH	denotes	-
T5877	27840-27846	JJ	denotes	dorsal
T5878	27856-27858	IN	denotes	of
T5879	27859-27865	NN	denotes	Agouti
T5880	27866-27876	NN	denotes	expression
T5881	27886-27888	TO	denotes	to
T5882	27889-27895	VB	denotes	extend
T5883	27896-27900	RBR	denotes	more
T5884	27901-27909	RB	denotes	dorsally
T5885	27910-27912	IN	denotes	in
T5886	27913-27916	NN	denotes	deH
T5887	27917-27920	NN	denotes	deH
T5888	27916-27917	HYPH	denotes	/
T5889	27921-27928	NNS	denotes	embryos
T5890	27929-27930	-LRB-	denotes	(
T5891	27930-27936	NN	denotes	Figure
T5892	27937-27939	CD	denotes	6A
T5893	27939-27940	-RRB-	denotes	)
T5894	27940-27941	.	denotes	.
T5895	27941-28128	sentence	denotes	In P4.5 skin, expression of Agouti is also extended dorsally in deH/deH animals and is most apparent in the midflank region within the upper dermis and dermal papillae cells (Figure 6B).
T5896	27942-27944	IN	denotes	In
T5897	27985-27993	VBN	denotes	extended
T5898	27945-27949	NN	denotes	P4.5
T5899	27950-27954	NN	denotes	skin
T5900	27954-27956	,	denotes	,
T5901	27956-27966	NN	denotes	expression
T5902	27967-27969	IN	denotes	of
T5903	27970-27976	NN	denotes	Agouti
T5904	27977-27979	VBZ	denotes	is
T5905	27980-27984	RB	denotes	also
T5906	27994-28002	RB	denotes	dorsally
T5907	28003-28005	IN	denotes	in
T5908	28006-28009	NN	denotes	deH
T5909	28010-28013	NN	denotes	deH
T5910	28009-28010	HYPH	denotes	/
T5911	28014-28021	NNS	denotes	animals
T5912	28022-28025	CC	denotes	and
T5913	28026-28028	VBZ	denotes	is
T5914	28029-28033	RBS	denotes	most
T5915	28034-28042	JJ	denotes	apparent
T5916	28043-28045	IN	denotes	in
T5917	28046-28049	DT	denotes	the
T5918	28059-28065	NN	denotes	region
T5919	28050-28058	JJ	denotes	midflank
T5920	28066-28072	IN	denotes	within
T5921	28073-28076	DT	denotes	the
T5922	28083-28089	NN	denotes	dermis
T5923	28077-28082	JJ	denotes	upper
T5924	28090-28093	CC	denotes	and
T5925	28094-28100	JJ	denotes	dermal
T5926	28110-28115	NNS	denotes	cells
T5927	28101-28109	NNS	denotes	papillae
T5928	28116-28117	-LRB-	denotes	(
T5929	28117-28123	NN	denotes	Figure
T5930	28124-28126	CD	denotes	6B
T5931	28126-28127	-RRB-	denotes	)
T5932	28127-28128	.	denotes	.
T5933	28128-28460	sentence	denotes	Thus, while the pigmentation phenotype of deH/deH mice can be explained, not surprisingly, by dorsal extension of Agouti expression after birth, patterned expression of Tbx15 and Agouti are apparent some 10 days earlier, between E12.5 and E13.5, and the effects of Tbx15 deficiency on expression of Agouti can be detected by E14.5.
T5934	28129-28133	RB	denotes	Thus
T5935	28315-28318	VBP	denotes	are
T5936	28133-28135	,	denotes	,
T5937	28135-28140	IN	denotes	while
T5938	28191-28200	VBN	denotes	explained
T5939	28141-28144	DT	denotes	the
T5940	28158-28167	NN	denotes	phenotype
T5941	28145-28157	NN	denotes	pigmentation
T5942	28168-28170	IN	denotes	of
T5943	28171-28174	NN	denotes	deH
T5944	28175-28178	NN	denotes	deH
T5945	28174-28175	HYPH	denotes	/
T5946	28179-28183	NNS	denotes	mice
T5947	28184-28187	MD	denotes	can
T5948	28188-28190	VB	denotes	be
T5949	28200-28202	,	denotes	,
T5950	28202-28205	RB	denotes	not
T5951	28206-28218	RB	denotes	surprisingly
T5952	28218-28220	,	denotes	,
T5953	28220-28222	IN	denotes	by
T5954	28223-28229	JJ	denotes	dorsal
T5955	28230-28239	NN	denotes	extension
T5956	28240-28242	IN	denotes	of
T5957	28243-28249	NN	denotes	Agouti
T5958	28250-28260	NN	denotes	expression
T5959	28261-28266	IN	denotes	after
T5960	28267-28272	NN	denotes	birth
T5961	28272-28274	,	denotes	,
T5962	28274-28283	VBN	denotes	patterned
T5963	28284-28294	NN	denotes	expression
T5964	28295-28297	IN	denotes	of
T5965	28298-28303	NN	denotes	Tbx15
T5966	28304-28307	CC	denotes	and
T5967	28308-28314	NN	denotes	Agouti
T5968	28319-28327	JJ	denotes	apparent
T5969	28328-28332	DT	denotes	some
T5970	28333-28335	CD	denotes	10
T5971	28336-28340	NNS	denotes	days
T5972	28341-28348	RBR	denotes	earlier
T5973	28348-28350	,	denotes	,
T5974	28350-28357	IN	denotes	between
T5975	28358-28363	NN	denotes	E12.5
T5976	28364-28367	CC	denotes	and
T5977	28368-28373	NN	denotes	E13.5
T5978	28373-28375	,	denotes	,
T5979	28375-28378	CC	denotes	and
T5980	28379-28382	DT	denotes	the
T5981	28383-28390	NNS	denotes	effects
T5982	28442-28450	VBN	denotes	detected
T5983	28391-28393	IN	denotes	of
T5984	28394-28399	NN	denotes	Tbx15
T5985	28400-28410	NN	denotes	deficiency
T5986	28411-28413	IN	denotes	on
T5987	28414-28424	NN	denotes	expression
T5988	28425-28427	IN	denotes	of
T5989	28428-28434	NN	denotes	Agouti
T5990	28435-28438	MD	denotes	can
T5991	28439-28441	VB	denotes	be
T5992	28451-28453	IN	denotes	by
T5993	28454-28459	NN	denotes	E14.5
T5994	28459-28460	.	denotes	.
T6165	29089-29101	NN	denotes	Relationship
T6166	29102-29104	IN	denotes	of
T6167	29105-29114	JJ	denotes	Embryonic
T6168	29121-29131	NN	denotes	Expression
T6169	29115-29120	NN	denotes	Tbx15
T6170	29132-29134	IN	denotes	to
T6171	29135-29141	JJ	denotes	Dorsal
T6172	29167-29174	NNS	denotes	Domains
T6173	29142-29145	CC	denotes	and
T6174	29146-29153	JJ	denotes	Ventral
T6175	29154-29166	NN	denotes	Pigmentation
T6176	29174-29466	sentence	denotes	The observations described above are consistent with a model in which transient expression of Tbx15 in the embryonic dorsal flank is required to establish positional identity of the future dermis, at least with respect to pigment-type synthesis caused by the ventral-specific Agouti isoform.
T6177	29175-29178	DT	denotes	The
T6178	29179-29191	NNS	denotes	observations
T6179	29208-29211	VBP	denotes	are
T6180	29192-29201	VBN	denotes	described
T6181	29202-29207	RB	denotes	above
T6182	29212-29222	JJ	denotes	consistent
T6183	29223-29227	IN	denotes	with
T6184	29228-29229	DT	denotes	a
T6185	29230-29235	NN	denotes	model
T6186	29236-29238	IN	denotes	in
T6187	29308-29316	VBN	denotes	required
T6188	29239-29244	WDT	denotes	which
T6189	29245-29254	JJ	denotes	transient
T6190	29255-29265	NN	denotes	expression
T6191	29266-29268	IN	denotes	of
T6192	29269-29274	NN	denotes	Tbx15
T6193	29275-29277	IN	denotes	in
T6194	29278-29281	DT	denotes	the
T6195	29299-29304	NN	denotes	flank
T6196	29282-29291	JJ	denotes	embryonic
T6197	29292-29298	JJ	denotes	dorsal
T6198	29305-29307	VBZ	denotes	is
T6199	29317-29319	TO	denotes	to
T6200	29320-29329	VB	denotes	establish
T6201	29330-29340	JJ	denotes	positional
T6202	29341-29349	NN	denotes	identity
T6203	29350-29352	IN	denotes	of
T6204	29353-29356	DT	denotes	the
T6205	29364-29370	NN	denotes	dermis
T6206	29357-29363	JJ	denotes	future
T6207	29370-29372	,	denotes	,
T6208	29372-29374	RB	denotes	at
T6209	29375-29380	RBS	denotes	least
T6210	29381-29385	IN	denotes	with
T6211	29386-29393	NN	denotes	respect
T6212	29394-29396	IN	denotes	to
T6213	29397-29404	NN	denotes	pigment
T6214	29405-29409	NN	denotes	type
T6215	29404-29405	HYPH	denotes	-
T6216	29410-29419	NN	denotes	synthesis
T6217	29420-29426	VBN	denotes	caused
T6218	29427-29429	IN	denotes	by
T6219	29430-29433	DT	denotes	the
T6220	29458-29465	NN	denotes	isoform
T6221	29434-29441	JJ	denotes	ventral
T6222	29442-29450	JJ	denotes	specific
T6223	29441-29442	HYPH	denotes	-
T6224	29451-29457	NN	denotes	Agouti
T6225	29465-29466	.	denotes	.
T6226	29466-29636	sentence	denotes	To further investigate this hypothesis, we carried out transplantation experiments in which pieces of embryonic skin were isolated from different dorsoventral positions.
T6227	29467-29469	TO	denotes	To
T6228	29478-29489	VB	denotes	investigate
T6229	29470-29477	RB	denotes	further
T6230	29510-29517	VBD	denotes	carried
T6231	29490-29494	DT	denotes	this
T6232	29495-29505	NN	denotes	hypothesis
T6233	29505-29507	,	denotes	,
T6234	29507-29509	PRP	denotes	we
T6235	29518-29521	RP	denotes	out
T6236	29522-29537	NN	denotes	transplantation
T6237	29538-29549	NNS	denotes	experiments
T6238	29550-29552	IN	denotes	in
T6239	29589-29597	VBN	denotes	isolated
T6240	29553-29558	WDT	denotes	which
T6241	29559-29565	NNS	denotes	pieces
T6242	29566-29568	IN	denotes	of
T6243	29569-29578	JJ	denotes	embryonic
T6244	29579-29583	NN	denotes	skin
T6245	29584-29588	VBD	denotes	were
T6246	29598-29602	IN	denotes	from
T6247	29603-29612	JJ	denotes	different
T6248	29626-29635	NNS	denotes	positions
T6249	29613-29625	JJ	denotes	dorsoventral
T6250	29635-29636	.	denotes	.
T6251	29636-29782	sentence	denotes	We evaluated the embryonic skin fragments for their potential to give rise to different hair colors and for their expression of Tbx15 and Agouti.
T6252	29637-29639	PRP	denotes	We
T6253	29640-29649	VBD	denotes	evaluated
T6254	29650-29653	DT	denotes	the
T6255	29669-29678	NNS	denotes	fragments
T6256	29654-29663	JJ	denotes	embryonic
T6257	29664-29668	NN	denotes	skin
T6258	29679-29682	IN	denotes	for
T6259	29683-29688	PRP$	denotes	their
T6260	29689-29698	NN	denotes	potential
T6261	29699-29701	TO	denotes	to
T6262	29702-29706	VB	denotes	give
T6263	29707-29711	NN	denotes	rise
T6264	29712-29714	IN	denotes	to
T6265	29715-29724	JJ	denotes	different
T6266	29730-29736	NNS	denotes	colors
T6267	29725-29729	NN	denotes	hair
T6268	29737-29740	CC	denotes	and
T6269	29741-29744	IN	denotes	for
T6270	29745-29750	PRP$	denotes	their
T6271	29751-29761	NN	denotes	expression
T6272	29762-29764	IN	denotes	of
T6273	29765-29770	NN	denotes	Tbx15
T6274	29771-29774	CC	denotes	and
T6275	29775-29781	NN	denotes	Agouti
T6276	29781-29782	.	denotes	.
T6277	29782-30037	sentence	denotes	Previous studies by Silvers and colleagues (Poole and Silvers 1976) showed that dorsal and ventral skin isolated from at/at embryos gives rise to black and yellow hair, respectively, when transplanted into testis and allowed to develop for several weeks.
T6278	29783-29791	JJ	denotes	Previous
T6279	29792-29799	NNS	denotes	studies
T6280	29851-29857	VBD	denotes	showed
T6281	29800-29802	IN	denotes	by
T6282	29803-29810	NNP	denotes	Silvers
T6283	29811-29814	CC	denotes	and
T6284	29815-29825	NNS	denotes	colleagues
T6285	29826-29827	-LRB-	denotes	(
T6286	29827-29832	NNP	denotes	Poole
T6287	29833-29836	CC	denotes	and
T6288	29837-29844	NNP	denotes	Silvers
T6289	29845-29849	CD	denotes	1976
T6290	29849-29850	-RRB-	denotes	)
T6291	29858-29862	IN	denotes	that
T6292	29915-29920	VBZ	denotes	gives
T6293	29863-29869	JJ	denotes	dorsal
T6294	29882-29886	NN	denotes	skin
T6295	29870-29873	CC	denotes	and
T6296	29874-29881	JJ	denotes	ventral
T6297	29887-29895	VBN	denotes	isolated
T6298	29896-29900	IN	denotes	from
T6299	29901-29903	NN	denotes	at
T6300	29904-29906	NN	denotes	at
T6301	29903-29904	HYPH	denotes	/
T6302	29907-29914	NNS	denotes	embryos
T6303	29921-29925	NN	denotes	rise
T6304	29926-29928	IN	denotes	to
T6305	29929-29934	JJ	denotes	black
T6306	29946-29950	NN	denotes	hair
T6307	29935-29938	CC	denotes	and
T6308	29939-29945	JJ	denotes	yellow
T6309	29950-29952	,	denotes	,
T6310	29952-29964	RB	denotes	respectively
T6311	29964-29966	,	denotes	,
T6312	29966-29970	WRB	denotes	when
T6313	29971-29983	VBN	denotes	transplanted
T6314	29984-29988	IN	denotes	into
T6315	29989-29995	NN	denotes	testis
T6316	29996-29999	CC	denotes	and
T6317	30000-30007	VBN	denotes	allowed
T6318	30008-30010	TO	denotes	to
T6319	30011-30018	VB	denotes	develop
T6320	30019-30022	IN	denotes	for
T6321	30023-30030	JJ	denotes	several
T6322	30031-30036	NNS	denotes	weeks
T6323	30036-30037	.	denotes	.
T6324	30037-30188	sentence	denotes	Furthermore, dermal–epidermal recombination experiments carried out at E14.5 demonstrated that positional identity is carried by the embryonic dermis.
T6325	30038-30049	RB	denotes	Furthermore
T6326	30115-30127	VBD	denotes	demonstrated
T6327	30049-30051	,	denotes	,
T6328	30051-30057	JJ	denotes	dermal
T6329	30058-30067	JJ	denotes	epidermal
T6330	30057-30058	HYPH	denotes	–
T6331	30082-30093	NNS	denotes	experiments
T6332	30068-30081	NN	denotes	recombination
T6333	30094-30101	VBN	denotes	carried
T6334	30102-30105	RP	denotes	out
T6335	30106-30108	IN	denotes	at
T6336	30109-30114	NN	denotes	E14.5
T6337	30128-30132	IN	denotes	that
T6338	30156-30163	VBN	denotes	carried
T6339	30133-30143	JJ	denotes	positional
T6340	30144-30152	NN	denotes	identity
T6341	30153-30155	VBZ	denotes	is
T6342	30164-30166	IN	denotes	by
T6343	30167-30170	DT	denotes	the
T6344	30181-30187	NN	denotes	dermis
T6345	30171-30180	JJ	denotes	embryonic
T6346	30187-30188	.	denotes	.
T6347	30188-30492	sentence	denotes	In a variation on this experiment, we divided embryonic skin from at/a embryos into dorsal, flank, and ventral pieces and analyzed the different pieces for their ability to give rise to black or yellow hair after testis transplantation, and, in parallel, for gene expression using in situ hybridization.
T6348	30189-30191	IN	denotes	In
T6349	30227-30234	VBD	denotes	divided
T6350	30192-30193	DT	denotes	a
T6351	30194-30203	NN	denotes	variation
T6352	30204-30206	IN	denotes	on
T6353	30207-30211	DT	denotes	this
T6354	30212-30222	NN	denotes	experiment
T6355	30222-30224	,	denotes	,
T6356	30224-30226	PRP	denotes	we
T6357	30235-30244	JJ	denotes	embryonic
T6358	30245-30249	NN	denotes	skin
T6359	30250-30254	IN	denotes	from
T6360	30255-30257	NN	denotes	at
T6361	30258-30259	NN	denotes	a
T6362	30257-30258	HYPH	denotes	/
T6363	30260-30267	NNS	denotes	embryos
T6364	30268-30272	IN	denotes	into
T6365	30273-30279	JJ	denotes	dorsal
T6366	30300-30306	NNS	denotes	pieces
T6367	30279-30281	,	denotes	,
T6368	30281-30286	NN	denotes	flank
T6369	30286-30288	,	denotes	,
T6370	30288-30291	CC	denotes	and
T6371	30292-30299	JJ	denotes	ventral
T6372	30307-30310	CC	denotes	and
T6373	30311-30319	VBD	denotes	analyzed
T6374	30320-30323	DT	denotes	the
T6375	30334-30340	NNS	denotes	pieces
T6376	30324-30333	JJ	denotes	different
T6377	30341-30344	IN	denotes	for
T6378	30345-30350	PRP$	denotes	their
T6379	30351-30358	NN	denotes	ability
T6380	30359-30361	TO	denotes	to
T6381	30362-30366	VB	denotes	give
T6382	30367-30371	NN	denotes	rise
T6383	30372-30374	IN	denotes	to
T6384	30375-30380	JJ	denotes	black
T6385	30391-30395	NN	denotes	hair
T6386	30381-30383	CC	denotes	or
T6387	30384-30390	JJ	denotes	yellow
T6388	30396-30401	IN	denotes	after
T6389	30402-30408	NN	denotes	testis
T6390	30409-30424	NN	denotes	transplantation
T6391	30424-30426	,	denotes	,
T6392	30426-30429	CC	denotes	and
T6393	30429-30431	,	denotes	,
T6394	30444-30447	IN	denotes	for
T6395	30431-30433	IN	denotes	in
T6396	30434-30442	NN	denotes	parallel
T6397	30442-30444	,	denotes	,
T6398	30448-30452	NN	denotes	gene
T6399	30453-30463	NN	denotes	expression
T6400	30464-30469	VBG	denotes	using
T6401	30470-30472	FW	denotes	in
T6402	30473-30477	FW	denotes	situ
T6403	30478-30491	NN	denotes	hybridization
T6404	30491-30492	.	denotes	.
T6405	30492-30885	sentence	denotes	For the purposes of a reproducible morphologic boundary, we divided flank from ventral skin based on a change in skin thickness and divided dorsal from flank skin at the level of an ectodermal notch that lies at the same level as the ventral extent of the myotome (Figure 7) (Huang and Christ 2000; Olivera-Martinez et al. 2000; Sudo et al. 2001; Burke and Nowicki 2003; Nowicki et al. 2003).
T6406	30493-30496	IN	denotes	For
T6407	30553-30560	VBD	denotes	divided
T6408	30497-30500	DT	denotes	the
T6409	30501-30509	NNS	denotes	purposes
T6410	30510-30512	IN	denotes	of
T6411	30513-30514	DT	denotes	a
T6412	30540-30548	NN	denotes	boundary
T6413	30515-30527	JJ	denotes	reproducible
T6414	30528-30539	JJ	denotes	morphologic
T6415	30548-30550	,	denotes	,
T6416	30550-30552	PRP	denotes	we
T6417	30561-30566	NN	denotes	flank
T6418	30567-30571	IN	denotes	from
T6419	30572-30579	JJ	denotes	ventral
T6420	30580-30584	NN	denotes	skin
T6421	30585-30590	VBN	denotes	based
T6422	30591-30593	IN	denotes	on
T6423	30594-30595	DT	denotes	a
T6424	30596-30602	NN	denotes	change
T6425	30603-30605	IN	denotes	in
T6426	30606-30610	NN	denotes	skin
T6427	30611-30620	NN	denotes	thickness
T6428	30621-30624	CC	denotes	and
T6429	30625-30632	VBN	denotes	divided
T6430	30633-30639	JJ	denotes	dorsal
T6431	30640-30644	IN	denotes	from
T6432	30645-30650	NN	denotes	flank
T6433	30651-30655	NN	denotes	skin
T6434	30656-30658	IN	denotes	at
T6435	30659-30662	DT	denotes	the
T6436	30663-30668	NN	denotes	level
T6437	30669-30671	IN	denotes	of
T6438	30672-30674	DT	denotes	an
T6439	30686-30691	NN	denotes	notch
T6440	30675-30685	JJ	denotes	ectodermal
T6441	30692-30696	WDT	denotes	that
T6442	30697-30701	VBZ	denotes	lies
T6443	30702-30704	IN	denotes	at
T6444	30705-30708	DT	denotes	the
T6445	30714-30719	NN	denotes	level
T6446	30709-30713	JJ	denotes	same
T6447	30720-30722	IN	denotes	as
T6448	30723-30726	DT	denotes	the
T6449	30735-30741	NN	denotes	extent
T6450	30727-30734	JJ	denotes	ventral
T6451	30742-30744	IN	denotes	of
T6452	30745-30748	DT	denotes	the
T6453	30749-30756	NN	denotes	myotome
T6454	30757-30758	-LRB-	denotes	(
T6455	30758-30764	NN	denotes	Figure
T6456	30765-30766	CD	denotes	7
T6457	30766-30767	-RRB-	denotes	)
T6458	30768-30769	-LRB-	denotes	(
T6459	30769-30774	NNP	denotes	Huang
T6460	30775-30778	CC	denotes	and
T6461	30779-30785	NNP	denotes	Christ
T6462	30786-30790	CD	denotes	2000
T6463	30790-30791	:	denotes	;
T6464	30792-30799	NNP	denotes	Olivera
T6465	30799-30800	HYPH	denotes	-
T6466	30800-30808	NNP	denotes	Martinez
T6467	30809-30811	FW	denotes	et
T6468	30812-30815	FW	denotes	al.
T6469	30816-30820	CD	denotes	2000
T6470	30820-30821	:	denotes	;
T6471	30822-30826	NNP	denotes	Sudo
T6472	30827-30829	FW	denotes	et
T6473	30830-30833	FW	denotes	al.
T6474	30834-30838	CD	denotes	2001
T6475	30838-30839	:	denotes	;
T6476	30840-30845	NNP	denotes	Burke
T6477	30846-30849	CC	denotes	and
T6478	30850-30857	NNP	denotes	Nowicki
T6479	30858-30862	CD	denotes	2003
T6480	30862-30863	:	denotes	;
T6481	30864-30871	NNP	denotes	Nowicki
T6482	30872-30874	FW	denotes	et
T6483	30875-30878	FW	denotes	al.
T6484	30879-30883	CD	denotes	2003
T6485	30883-30884	-RRB-	denotes	)
T6486	30884-30885	.	denotes	.
T6487	30885-31727	sentence	denotes	Figure 7 Embryonic Establishment of Dorsoventral Skin Patterning Pieces of skin from dorsal, flank, and ventral regions of at/a E12.5 embryos were transplanted into the testes of congenic animals as described in the text. Hair color of the grafts was examined 3 wk later. Grafts of ventral embryonic skin (n = 3) produced yellow hairs, dorsal embryonic skin (n = 4) produced black hairs, and flank embryonic skin produced mostly (13 out of 15) black and yellow hairs in distinct regions as shown. In parallel, in situ hybridization studies revealed that the embryonic flank contains the boundary of expression between Agouti and Tbx15 (scale bars = 1 mm for hairs and 200 μm for in situ hybridization results). We found that E12.5 is the earliest time at which embryonic ventral skin is able to produce hair when transplanted to the testis.
T6488	31598-31600	PRP	denotes	We
T6489	31601-31606	VBD	denotes	found
T6490	31607-31611	IN	denotes	that
T6491	31618-31620	VBZ	denotes	is
T6492	31612-31617	NN	denotes	E12.5
T6493	31621-31624	DT	denotes	the
T6494	31634-31638	NN	denotes	time
T6495	31625-31633	JJS	denotes	earliest
T6496	31639-31641	IN	denotes	at
T6497	31671-31673	VBZ	denotes	is
T6498	31642-31647	WDT	denotes	which
T6499	31648-31657	JJ	denotes	embryonic
T6500	31666-31670	NN	denotes	skin
T6501	31658-31665	JJ	denotes	ventral
T6502	31674-31678	JJ	denotes	able
T6503	31679-31681	TO	denotes	to
T6504	31682-31689	VB	denotes	produce
T6505	31690-31694	NN	denotes	hair
T6506	31695-31699	WRB	denotes	when
T6507	31700-31712	VBN	denotes	transplanted
T6508	31713-31715	IN	denotes	to
T6509	31716-31719	DT	denotes	the
T6510	31720-31726	NN	denotes	testis
T6511	31726-31727	.	denotes	.
T6512	31727-31857	sentence	denotes	Of the grafts that produced hair, ventral skin gave rise to yellow hair (n = 3), and dorsal skin gave rise to black hair (n = 4).
T6513	31728-31730	IN	denotes	Of
T6514	31775-31779	VBD	denotes	gave
T6515	31731-31734	DT	denotes	the
T6516	31735-31741	NNS	denotes	grafts
T6517	31742-31746	WDT	denotes	that
T6518	31747-31755	VBD	denotes	produced
T6519	31756-31760	NN	denotes	hair
T6520	31760-31762	,	denotes	,
T6521	31762-31769	JJ	denotes	ventral
T6522	31770-31774	NN	denotes	skin
T6523	31780-31784	NN	denotes	rise
T6524	31785-31787	IN	denotes	to
T6525	31788-31794	JJ	denotes	yellow
T6526	31795-31799	NN	denotes	hair
T6527	31800-31801	-LRB-	denotes	(
T6528	31805-31806	CD	denotes	3
T6529	31801-31802	NN	denotes	n
T6530	31803-31804	SYM	denotes	=
T6531	31806-31807	-RRB-	denotes	)
T6532	31807-31809	,	denotes	,
T6533	31809-31812	CC	denotes	and
T6534	31813-31819	JJ	denotes	dorsal
T6535	31820-31824	NN	denotes	skin
T6536	31825-31829	VBD	denotes	gave
T6537	31830-31834	NN	denotes	rise
T6538	31835-31837	IN	denotes	to
T6539	31838-31843	JJ	denotes	black
T6540	31844-31848	NN	denotes	hair
T6541	31849-31850	-LRB-	denotes	(
T6542	31854-31855	CD	denotes	4
T6543	31850-31851	NN	denotes	n
T6544	31852-31853	SYM	denotes	=
T6545	31855-31856	-RRB-	denotes	)
T6546	31856-31857	.	denotes	.
T6547	31857-32075	sentence	denotes	Transplantation of flank skin gave rise to a patch of yellow hair juxtaposed against a patch of black hair in 85% of the successful grafts (n = 13); the remaining two flank grafts produced solely black or yellow hair.
T6548	31858-31873	NN	denotes	Transplantation
T6549	31888-31892	VBD	denotes	gave
T6550	31874-31876	IN	denotes	of
T6551	31877-31882	NN	denotes	flank
T6552	31883-31887	NN	denotes	skin
T6553	32038-32046	VBD	denotes	produced
T6554	31893-31897	NN	denotes	rise
T6555	31898-31900	IN	denotes	to
T6556	31901-31902	DT	denotes	a
T6557	31903-31908	NN	denotes	patch
T6558	31909-31911	IN	denotes	of
T6559	31912-31918	JJ	denotes	yellow
T6560	31919-31923	NN	denotes	hair
T6561	31924-31934	VBN	denotes	juxtaposed
T6562	31935-31942	IN	denotes	against
T6563	31943-31944	DT	denotes	a
T6564	31945-31950	NN	denotes	patch
T6565	31951-31953	IN	denotes	of
T6566	31954-31959	JJ	denotes	black
T6567	31960-31964	NN	denotes	hair
T6568	31965-31967	IN	denotes	in
T6569	31968-31970	CD	denotes	85
T6570	31970-31971	NN	denotes	%
T6571	31972-31974	IN	denotes	of
T6572	31975-31978	DT	denotes	the
T6573	31990-31996	NNS	denotes	grafts
T6574	31979-31989	JJ	denotes	successful
T6575	31997-31998	-LRB-	denotes	(
T6576	32002-32004	CD	denotes	13
T6577	31998-31999	NN	denotes	n
T6578	32000-32001	SYM	denotes	=
T6579	32004-32005	-RRB-	denotes	)
T6580	32005-32006	:	denotes	;
T6581	32007-32010	DT	denotes	the
T6582	32031-32037	NNS	denotes	grafts
T6583	32011-32020	VBG	denotes	remaining
T6584	32021-32024	CD	denotes	two
T6585	32025-32030	NN	denotes	flank
T6586	32047-32053	RB	denotes	solely
T6587	32054-32059	JJ	denotes	black
T6588	32070-32074	NN	denotes	hair
T6589	32060-32062	CC	denotes	or
T6590	32063-32069	JJ	denotes	yellow
T6591	32074-32075	.	denotes	.
T6592	32075-32142	sentence	denotes	In no case did we observe intermingling of black and yellow hairs.
T6593	32076-32078	IN	denotes	In
T6594	32094-32101	VBP	denotes	observe
T6595	32079-32081	DT	denotes	no
T6596	32082-32086	NN	denotes	case
T6597	32087-32090	VBD	denotes	did
T6598	32091-32093	PRP	denotes	we
T6599	32102-32115	VBG	denotes	intermingling
T6600	32116-32118	IN	denotes	of
T6601	32119-32124	JJ	denotes	black
T6602	32136-32141	NNS	denotes	hairs
T6603	32125-32128	CC	denotes	and
T6604	32129-32135	JJ	denotes	yellow
T6605	32141-32142	.	denotes	.
T6606	32142-32323	sentence	denotes	As predicted from the experiments using tissue sections (see Figures 5 and 6), dorsal pieces expressed Tbx15 but not Agouti, while flank pieces expressed both genes (see Figure 7).
T6607	32143-32145	IN	denotes	As
T6608	32146-32155	VBN	denotes	predicted
T6609	32236-32245	VBD	denotes	expressed
T6610	32156-32160	IN	denotes	from
T6611	32161-32164	DT	denotes	the
T6612	32165-32176	NNS	denotes	experiments
T6613	32177-32182	VBG	denotes	using
T6614	32183-32189	NN	denotes	tissue
T6615	32190-32198	NNS	denotes	sections
T6616	32199-32200	-LRB-	denotes	(
T6617	32200-32203	VB	denotes	see
T6618	32204-32211	NNS	denotes	Figures
T6619	32212-32213	CD	denotes	5
T6620	32214-32217	CC	denotes	and
T6621	32218-32219	CD	denotes	6
T6622	32219-32220	-RRB-	denotes	)
T6623	32220-32222	,	denotes	,
T6624	32222-32228	JJ	denotes	dorsal
T6625	32229-32235	NNS	denotes	pieces
T6626	32246-32251	NN	denotes	Tbx15
T6627	32252-32255	CC	denotes	but
T6628	32256-32259	RB	denotes	not
T6629	32260-32266	NN	denotes	Agouti
T6630	32266-32268	,	denotes	,
T6631	32268-32273	IN	denotes	while
T6632	32287-32296	VBD	denotes	expressed
T6633	32274-32279	NN	denotes	flank
T6634	32280-32286	NNS	denotes	pieces
T6635	32297-32301	DT	denotes	both
T6636	32302-32307	NNS	denotes	genes
T6637	32308-32309	-LRB-	denotes	(
T6638	32309-32312	VB	denotes	see
T6639	32313-32319	NN	denotes	Figure
T6640	32320-32321	CD	denotes	7
T6641	32321-32322	-RRB-	denotes	)
T6642	32322-32323	.	denotes	.
T6643	32323-32656	sentence	denotes	Thus, dorsoventral identity for adult pigmentation is established by the time when patterned expression becomes apparent for Tbx15 and Agouti (E11.5–E12.5); furthermore, positional identity is maintained throughout later stages of skin development, even though expression of Tbx15 broadens to include ventral as well as dorsal skin.
T6644	32324-32328	RB	denotes	Thus
T6645	32378-32389	VBN	denotes	established
T6646	32328-32330	,	denotes	,
T6647	32330-32342	JJ	denotes	dorsoventral
T6648	32343-32351	NN	denotes	identity
T6649	32352-32355	IN	denotes	for
T6650	32356-32361	JJ	denotes	adult
T6651	32362-32374	NN	denotes	pigmentation
T6652	32375-32377	VBZ	denotes	is
T6653	32517-32527	VBN	denotes	maintained
T6654	32390-32392	IN	denotes	by
T6655	32393-32396	DT	denotes	the
T6656	32397-32401	NN	denotes	time
T6657	32402-32406	WRB	denotes	when
T6658	32428-32435	VBZ	denotes	becomes
T6659	32407-32416	VBN	denotes	patterned
T6660	32417-32427	NN	denotes	expression
T6661	32436-32444	JJ	denotes	apparent
T6662	32445-32448	IN	denotes	for
T6663	32449-32454	NN	denotes	Tbx15
T6664	32455-32458	CC	denotes	and
T6665	32459-32465	NN	denotes	Agouti
T6666	32466-32467	-LRB-	denotes	(
T6667	32467-32472	NN	denotes	E11.5
T6668	32472-32473	SYM	denotes	–
T6669	32473-32478	NN	denotes	E12.5
T6670	32478-32479	-RRB-	denotes	)
T6671	32479-32480	:	denotes	;
T6672	32481-32492	RB	denotes	furthermore
T6673	32492-32494	,	denotes	,
T6674	32494-32504	JJ	denotes	positional
T6675	32505-32513	NN	denotes	identity
T6676	32514-32516	VBZ	denotes	is
T6677	32528-32538	IN	denotes	throughout
T6678	32539-32544	JJ	denotes	later
T6679	32545-32551	NNS	denotes	stages
T6680	32552-32554	IN	denotes	of
T6681	32555-32559	NN	denotes	skin
T6682	32560-32571	NN	denotes	development
T6683	32571-32573	,	denotes	,
T6684	32573-32577	RB	denotes	even
T6685	32605-32613	VBZ	denotes	broadens
T6686	32578-32584	IN	denotes	though
T6687	32585-32595	NN	denotes	expression
T6688	32596-32598	IN	denotes	of
T6689	32599-32604	NN	denotes	Tbx15
T6690	32614-32616	TO	denotes	to
T6691	32617-32624	VB	denotes	include
T6692	32625-32632	JJ	denotes	ventral
T6693	32651-32655	NN	denotes	skin
T6694	32633-32635	RB	denotes	as
T6695	32641-32643	IN	denotes	as
T6696	32636-32640	RB	denotes	well
T6697	32644-32650	JJ	denotes	dorsal
T6698	32655-32656	.	denotes	.
T6883	32658-32670	NN	denotes	Relationship
T6884	32671-32673	IN	denotes	of
T6885	32674-32677	DT	denotes	the
T6886	32699-32707	NN	denotes	Boundary
T6887	32678-32690	JJ	denotes	Dorsoventral
T6888	32691-32698	NN	denotes	Pigment
T6889	32708-32710	IN	denotes	to
T6890	32711-32718	NN	denotes	Lineage
T6891	32719-32731	NNS	denotes	Compartments
T6892	32732-32735	CC	denotes	and
T6893	32736-32739	DT	denotes	the
T6894	32756-32764	NN	denotes	Frontier
T6895	32740-32747	JJ	denotes	Lateral
T6896	32748-32755	JJ	denotes	Somitic
T6897	32764-32915	sentence	denotes	The ectodermal notch that we used to mark the boundary between embryonic dorsum and embryonic flank is a characteristic feature in vertebrate embryos.
T6898	32765-32768	DT	denotes	The
T6899	32780-32785	NN	denotes	notch
T6900	32769-32779	JJ	denotes	ectodermal
T6901	32865-32867	VBZ	denotes	is
T6902	32786-32790	WDT	denotes	that
T6903	32794-32798	VBD	denotes	used
T6904	32791-32793	PRP	denotes	we
T6905	32799-32801	TO	denotes	to
T6906	32802-32806	VB	denotes	mark
T6907	32807-32810	DT	denotes	the
T6908	32811-32819	NN	denotes	boundary
T6909	32820-32827	IN	denotes	between
T6910	32828-32837	JJ	denotes	embryonic
T6911	32838-32844	NN	denotes	dorsum
T6912	32845-32848	CC	denotes	and
T6913	32849-32858	JJ	denotes	embryonic
T6914	32859-32864	NN	denotes	flank
T6915	32868-32869	DT	denotes	a
T6916	32885-32892	NN	denotes	feature
T6917	32870-32884	JJ	denotes	characteristic
T6918	32893-32895	IN	denotes	in
T6919	32896-32906	NN	denotes	vertebrate
T6920	32907-32914	NNS	denotes	embryos
T6921	32914-32915	.	denotes	.
T6922	32915-33258	sentence	denotes	In cell lineage studies carried out in the chick system, the notch serves as a landmark for the boundary between dermis derived from somitic mesoderm and dermis derived from lateral plate mesoderm and has been termed the “lateral somitic frontier” (Olivera-Martinez et al. 2000; Sudo et al. 2001; Burke and Nowicki 2003; Nowicki et al. 2003).
T6923	32916-32918	IN	denotes	In
T6924	32983-32989	VBZ	denotes	serves
T6925	32919-32923	NN	denotes	cell
T6926	32932-32939	NNS	denotes	studies
T6927	32924-32931	NN	denotes	lineage
T6928	32940-32947	VBN	denotes	carried
T6929	32948-32951	RP	denotes	out
T6930	32952-32954	IN	denotes	in
T6931	32955-32958	DT	denotes	the
T6932	32965-32971	NN	denotes	system
T6933	32959-32964	NN	denotes	chick
T6934	32971-32973	,	denotes	,
T6935	32973-32976	DT	denotes	the
T6936	32977-32982	NN	denotes	notch
T6937	32990-32992	IN	denotes	as
T6938	32993-32994	DT	denotes	a
T6939	32995-33003	NN	denotes	landmark
T6940	33004-33007	IN	denotes	for
T6941	33008-33011	DT	denotes	the
T6942	33012-33020	NN	denotes	boundary
T6943	33021-33028	IN	denotes	between
T6944	33029-33035	NN	denotes	dermis
T6945	33036-33043	VBN	denotes	derived
T6946	33044-33048	IN	denotes	from
T6947	33049-33056	JJ	denotes	somitic
T6948	33057-33065	NN	denotes	mesoderm
T6949	33066-33069	CC	denotes	and
T6950	33070-33076	NN	denotes	dermis
T6951	33077-33084	VBN	denotes	derived
T6952	33085-33089	IN	denotes	from
T6953	33090-33097	JJ	denotes	lateral
T6954	33098-33103	NN	denotes	plate
T6955	33104-33112	NN	denotes	mesoderm
T6956	33113-33116	CC	denotes	and
T6957	33117-33120	VBZ	denotes	has
T6958	33126-33132	VBN	denotes	termed
T6959	33121-33125	VBN	denotes	been
T6960	33133-33136	DT	denotes	the
T6961	33154-33162	NN	denotes	frontier
T6962	33137-33138	``	denotes	“
T6963	33138-33145	JJ	denotes	lateral
T6964	33146-33153	JJ	denotes	somitic
T6965	33162-33163	''	denotes	”
T6966	33164-33165	-LRB-	denotes	(
T6967	33165-33172	NNP	denotes	Olivera
T6968	33172-33173	HYPH	denotes	-
T6969	33173-33181	NNP	denotes	Martinez
T6970	33182-33184	FW	denotes	et
T6971	33185-33188	FW	denotes	al.
T6972	33189-33193	CD	denotes	2000
T6973	33193-33194	:	denotes	;
T6974	33195-33199	NNP	denotes	Sudo
T6975	33200-33202	FW	denotes	et
T6976	33203-33206	FW	denotes	al.
T6977	33207-33211	CD	denotes	2001
T6978	33211-33212	:	denotes	;
T6979	33213-33218	NNP	denotes	Burke
T6980	33219-33222	CC	denotes	and
T6981	33223-33230	NNP	denotes	Nowicki
T6982	33231-33235	CD	denotes	2003
T6983	33235-33236	:	denotes	;
T6984	33237-33244	NNP	denotes	Nowicki
T6985	33245-33247	FW	denotes	et
T6986	33248-33251	FW	denotes	al.
T6987	33252-33256	CD	denotes	2003
T6988	33256-33257	-RRB-	denotes	)
T6989	33257-33258	.	denotes	.
T6990	33258-33485	sentence	denotes	Although fate-mapping studies have not been carried out in mammalian embryos, somite- and lateral plate-derived mesoderm could give rise to precursors for dermis dorsal and ventral to the limb–body wall junction, respectively.
T6991	33259-33267	IN	denotes	Although
T6992	33303-33310	VBN	denotes	carried
T6993	33268-33272	NN	denotes	fate
T6994	33273-33280	VBG	denotes	mapping
T6995	33272-33273	HYPH	denotes	-
T6996	33281-33288	NNS	denotes	studies
T6997	33289-33293	VBP	denotes	have
T6998	33294-33297	RB	denotes	not
T6999	33298-33302	VBN	denotes	been
T7000	33386-33390	VB	denotes	give
T7001	33311-33314	RP	denotes	out
T7002	33315-33317	IN	denotes	in
T7003	33318-33327	JJ	denotes	mammalian
T7004	33328-33335	NNS	denotes	embryos
T7005	33335-33337	,	denotes	,
T7006	33337-33343	NN	denotes	somite
T7007	33363-33370	VBN	denotes	derived
T7008	33343-33344	HYPH	denotes	-
T7009	33345-33348	CC	denotes	and
T7010	33349-33356	JJ	denotes	lateral
T7011	33357-33362	NN	denotes	plate
T7012	33362-33363	HYPH	denotes	-
T7013	33371-33379	NN	denotes	mesoderm
T7014	33380-33385	MD	denotes	could
T7015	33391-33395	NN	denotes	rise
T7016	33396-33398	IN	denotes	to
T7017	33399-33409	NNS	denotes	precursors
T7018	33410-33413	IN	denotes	for
T7019	33414-33420	NN	denotes	dermis
T7020	33421-33427	JJ	denotes	dorsal
T7021	33428-33431	CC	denotes	and
T7022	33432-33439	JJ	denotes	ventral
T7023	33440-33442	IN	denotes	to
T7024	33443-33446	DT	denotes	the
T7025	33462-33470	NN	denotes	junction
T7026	33447-33451	NN	denotes	limb
T7027	33451-33452	HYPH	denotes	–
T7028	33452-33456	NN	denotes	body
T7029	33457-33461	NN	denotes	wall
T7030	33470-33472	,	denotes	,
T7031	33472-33484	RB	denotes	respectively
T7032	33484-33485	.	denotes	.
T7033	33485-33628	sentence	denotes	However, this notion conflicts with our observation that the future pigmentation boundary lies ventral to the ectodermal notch (see Figure 7).
T7034	33486-33493	RB	denotes	However
T7035	33507-33516	VBZ	denotes	conflicts
T7036	33493-33495	,	denotes	,
T7037	33495-33499	DT	denotes	this
T7038	33500-33506	NN	denotes	notion
T7039	33517-33521	IN	denotes	with
T7040	33522-33525	PRP$	denotes	our
T7041	33526-33537	NN	denotes	observation
T7042	33538-33542	IN	denotes	that
T7043	33576-33580	VBZ	denotes	lies
T7044	33543-33546	DT	denotes	the
T7045	33567-33575	NN	denotes	boundary
T7046	33547-33553	JJ	denotes	future
T7047	33554-33566	NN	denotes	pigmentation
T7048	33581-33588	RB	denotes	ventral
T7049	33589-33591	IN	denotes	to
T7050	33592-33595	DT	denotes	the
T7051	33607-33612	NN	denotes	notch
T7052	33596-33606	JJ	denotes	ectodermal
T7053	33613-33614	-LRB-	denotes	(
T7054	33614-33617	VB	denotes	see
T7055	33618-33624	NN	denotes	Figure
T7056	33625-33626	CD	denotes	7
T7057	33626-33627	-RRB-	denotes	)
T7058	33627-33628	.	denotes	.
T7059	33628-33870	sentence	denotes	To examine directly the relationship between the pigmentation boundary and dermis derived from lateral plate mesoderm, we made use of a Cre transgene driven by the Hoxb6 promoter that was developed by Kuehn and colleagues (Lowe et al. 2000).
T7060	33629-33631	TO	denotes	To
T7061	33632-33639	VB	denotes	examine
T7062	33751-33755	VBD	denotes	made
T7063	33640-33648	RB	denotes	directly
T7064	33649-33652	DT	denotes	the
T7065	33653-33665	NN	denotes	relationship
T7066	33666-33673	IN	denotes	between
T7067	33674-33677	DT	denotes	the
T7068	33691-33699	NN	denotes	boundary
T7069	33678-33690	NN	denotes	pigmentation
T7070	33700-33703	CC	denotes	and
T7071	33704-33710	NN	denotes	dermis
T7072	33711-33718	VBN	denotes	derived
T7073	33719-33723	IN	denotes	from
T7074	33724-33731	JJ	denotes	lateral
T7075	33732-33737	NN	denotes	plate
T7076	33738-33746	NN	denotes	mesoderm
T7077	33746-33748	,	denotes	,
T7078	33748-33750	PRP	denotes	we
T7079	33756-33759	NN	denotes	use
T7080	33760-33762	IN	denotes	of
T7081	33763-33764	DT	denotes	a
T7082	33769-33778	NN	denotes	transgene
T7083	33765-33768	NN	denotes	Cre
T7084	33779-33785	VBN	denotes	driven
T7085	33786-33788	IN	denotes	by
T7086	33789-33792	DT	denotes	the
T7087	33799-33807	NN	denotes	promoter
T7088	33793-33798	NN	denotes	Hoxb6
T7089	33808-33812	WDT	denotes	that
T7090	33817-33826	VBN	denotes	developed
T7091	33813-33816	VBD	denotes	was
T7092	33827-33829	IN	denotes	by
T7093	33830-33835	NNP	denotes	Kuehn
T7094	33836-33839	CC	denotes	and
T7095	33840-33850	NNS	denotes	colleagues
T7096	33851-33852	-LRB-	denotes	(
T7097	33852-33856	NNP	denotes	Lowe
T7098	33857-33859	FW	denotes	et
T7099	33860-33863	FW	denotes	al.
T7100	33864-33868	CD	denotes	2000
T7101	33868-33869	-RRB-	denotes	)
T7102	33869-33870	.	denotes	.
T7103	33870-34107	sentence	denotes	As described by Lowe et al. (2000), midgestation embryos carrying both the Hoxb6-Cre transgene and the R26R lacZ reporter gene (Soriano 1999) exhibit X-Gal staining in lateral plate mesoderm but not somite-derived mesoderm of the trunk.
T7104	33871-33873	IN	denotes	As
T7105	33874-33883	VBN	denotes	described
T7106	34013-34020	VBP	denotes	exhibit
T7107	33884-33886	IN	denotes	by
T7108	33887-33891	NNP	denotes	Lowe
T7109	33892-33894	FW	denotes	et
T7110	33895-33898	FW	denotes	al.
T7111	33899-33900	-LRB-	denotes	(
T7112	33900-33904	CD	denotes	2000
T7113	33904-33905	-RRB-	denotes	)
T7114	33905-33907	,	denotes	,
T7115	33907-33919	NN	denotes	midgestation
T7116	33920-33927	NNS	denotes	embryos
T7117	33928-33936	VBG	denotes	carrying
T7118	33937-33941	CC	denotes	both
T7119	33956-33965	NN	denotes	transgene
T7120	33942-33945	DT	denotes	the
T7121	33946-33951	NN	denotes	Hoxb6
T7122	33952-33955	NN	denotes	Cre
T7123	33951-33952	HYPH	denotes	-
T7124	33966-33969	CC	denotes	and
T7125	33970-33973	DT	denotes	the
T7126	33993-33997	NN	denotes	gene
T7127	33974-33978	NN	denotes	R26R
T7128	33979-33983	NN	denotes	lacZ
T7129	33984-33992	NN	denotes	reporter
T7130	33998-33999	-LRB-	denotes	(
T7131	33999-34006	NNP	denotes	Soriano
T7132	34007-34011	CD	denotes	1999
T7133	34011-34012	-RRB-	denotes	)
T7134	34021-34022	NN	denotes	X
T7135	34023-34026	NN	denotes	Gal
T7136	34022-34023	HYPH	denotes	-
T7137	34027-34035	NN	denotes	staining
T7138	34036-34038	IN	denotes	in
T7139	34039-34046	JJ	denotes	lateral
T7140	34047-34052	NN	denotes	plate
T7141	34053-34061	NN	denotes	mesoderm
T7142	34062-34065	CC	denotes	but
T7143	34066-34069	RB	denotes	not
T7144	34070-34076	NN	denotes	somite
T7145	34077-34084	VBN	denotes	derived
T7146	34076-34077	HYPH	denotes	-
T7147	34085-34093	NN	denotes	mesoderm
T7148	34094-34096	IN	denotes	of
T7149	34097-34100	DT	denotes	the
T7150	34101-34106	NN	denotes	trunk
T7151	34106-34107	.	denotes	.
T7152	34107-34334	sentence	denotes	In whole-mount skin preparations from P1.5 or P4.5 neonatal animals, we observed a ventral band of dark X-Gal staining corresponding to lateral plate-derived dermis, which represents 63% of the total circumference (Figure 8A).
T7153	34108-34110	IN	denotes	In
T7154	34180-34188	VBD	denotes	observed
T7155	34111-34116	JJ	denotes	whole
T7156	34117-34122	NN	denotes	mount
T7157	34116-34117	HYPH	denotes	-
T7158	34128-34140	NNS	denotes	preparations
T7159	34123-34127	NN	denotes	skin
T7160	34141-34145	IN	denotes	from
T7161	34146-34150	NN	denotes	P1.5
T7162	34168-34175	NNS	denotes	animals
T7163	34151-34153	CC	denotes	or
T7164	34154-34158	NN	denotes	P4.5
T7165	34159-34167	JJ	denotes	neonatal
T7166	34175-34177	,	denotes	,
T7167	34177-34179	PRP	denotes	we
T7168	34189-34190	DT	denotes	a
T7169	34199-34203	NN	denotes	band
T7170	34191-34198	JJ	denotes	ventral
T7171	34204-34206	IN	denotes	of
T7172	34207-34211	JJ	denotes	dark
T7173	34218-34226	NN	denotes	staining
T7174	34212-34213	NN	denotes	X
T7175	34213-34214	HYPH	denotes	-
T7176	34214-34217	NN	denotes	Gal
T7177	34227-34240	VBG	denotes	corresponding
T7178	34241-34243	IN	denotes	to
T7179	34244-34251	JJ	denotes	lateral
T7180	34252-34257	NN	denotes	plate
T7181	34258-34265	VBN	denotes	derived
T7182	34257-34258	HYPH	denotes	-
T7183	34266-34272	NN	denotes	dermis
T7184	34272-34274	,	denotes	,
T7185	34274-34279	WDT	denotes	which
T7186	34280-34290	VBZ	denotes	represents
T7187	34291-34293	CD	denotes	63
T7188	34293-34294	NN	denotes	%
T7189	34295-34297	IN	denotes	of
T7190	34298-34301	DT	denotes	the
T7191	34308-34321	NN	denotes	circumference
T7192	34302-34307	JJ	denotes	total
T7193	34322-34323	-LRB-	denotes	(
T7194	34323-34329	NN	denotes	Figure
T7195	34330-34332	CD	denotes	8A
T7196	34332-34333	-RRB-	denotes	)
T7197	34333-34334	.	denotes	.
T7198	34334-34617	sentence	denotes	However, in parallel preparations from at/at mice, the ventral pheomelanin domain represents 47% of the total skin circumference; therefore, the proportions of total skin circumference occupied by dorsal eumelanin and somite-derived dermis are 53% and 37%, respectively (Figure 8B).
T7199	34335-34342	RB	denotes	However
T7200	34417-34427	VBZ	denotes	represents
T7201	34342-34344	,	denotes	,
T7202	34344-34346	IN	denotes	in
T7203	34347-34355	JJ	denotes	parallel
T7204	34356-34368	NNS	denotes	preparations
T7205	34369-34373	IN	denotes	from
T7206	34374-34376	NN	denotes	at
T7207	34377-34379	NN	denotes	at
T7208	34376-34377	HYPH	denotes	/
T7209	34380-34384	NNS	denotes	mice
T7210	34384-34386	,	denotes	,
T7211	34386-34389	DT	denotes	the
T7212	34410-34416	NN	denotes	domain
T7213	34390-34397	JJ	denotes	ventral
T7214	34398-34409	NN	denotes	pheomelanin
T7215	34575-34578	VBP	denotes	are
T7216	34428-34430	CD	denotes	47
T7217	34430-34431	NN	denotes	%
T7218	34432-34434	IN	denotes	of
T7219	34435-34438	DT	denotes	the
T7220	34450-34463	NN	denotes	circumference
T7221	34439-34444	JJ	denotes	total
T7222	34445-34449	NN	denotes	skin
T7223	34463-34464	:	denotes	;
T7224	34465-34474	RB	denotes	therefore
T7225	34474-34476	,	denotes	,
T7226	34476-34479	DT	denotes	the
T7227	34480-34491	NNS	denotes	proportions
T7228	34492-34494	IN	denotes	of
T7229	34495-34500	JJ	denotes	total
T7230	34506-34519	NN	denotes	circumference
T7231	34501-34505	NN	denotes	skin
T7232	34520-34528	VBN	denotes	occupied
T7233	34529-34531	IN	denotes	by
T7234	34532-34538	JJ	denotes	dorsal
T7235	34539-34548	NN	denotes	eumelanin
T7236	34568-34574	NN	denotes	dermis
T7237	34549-34552	CC	denotes	and
T7238	34553-34559	NN	denotes	somite
T7239	34560-34567	VBN	denotes	derived
T7240	34559-34560	HYPH	denotes	-
T7241	34579-34581	CD	denotes	53
T7242	34581-34582	NN	denotes	%
T7243	34583-34586	CC	denotes	and
T7244	34587-34589	CD	denotes	37
T7245	34589-34590	NN	denotes	%
T7246	34590-34592	,	denotes	,
T7247	34592-34604	RB	denotes	respectively
T7248	34605-34606	-LRB-	denotes	(
T7249	34606-34612	NN	denotes	Figure
T7250	34613-34615	CD	denotes	8B
T7251	34615-34616	-RRB-	denotes	)
T7252	34616-34617	.	denotes	.
T7253	34617-34781	sentence	denotes	These results indicate that the pigmentation boundary is clearly distinct from, and more ventral to, the boundary between lateral plate- and somite-derived dermis.
T7254	34618-34623	DT	denotes	These
T7255	34624-34631	NNS	denotes	results
T7256	34632-34640	VBP	denotes	indicate
T7257	34641-34645	IN	denotes	that
T7258	34672-34674	VBZ	denotes	is
T7259	34646-34649	DT	denotes	the
T7260	34663-34671	NN	denotes	boundary
T7261	34650-34662	NN	denotes	pigmentation
T7262	34675-34682	RB	denotes	clearly
T7263	34683-34691	JJ	denotes	distinct
T7264	34692-34696	IN	denotes	from
T7265	34696-34698	,	denotes	,
T7266	34698-34701	CC	denotes	and
T7267	34702-34706	RBR	denotes	more
T7268	34707-34714	JJ	denotes	ventral
T7269	34715-34717	IN	denotes	to
T7270	34717-34719	,	denotes	,
T7271	34719-34722	DT	denotes	the
T7272	34723-34731	NN	denotes	boundary
T7273	34732-34739	IN	denotes	between
T7274	34740-34747	JJ	denotes	lateral
T7275	34748-34753	NN	denotes	plate
T7276	34766-34773	VBN	denotes	derived
T7277	34753-34754	HYPH	denotes	-
T7278	34755-34758	CC	denotes	and
T7279	34759-34765	NN	denotes	somite
T7280	34765-34766	HYPH	denotes	-
T7281	34774-34780	NN	denotes	dermis
T7282	34780-34781	.	denotes	.
T7283	34781-36057	sentence	denotes	Figure 8 Comparison of the Dorsoventral at/at Pigmentation Boundary to the Lateral Somitic Frontier (A) Dorsoventral slices of skin from at the midtrunk region prepared such that the dorsal midline lies in the center of the slice. Sections were taken at P1.5 (a) or P4.5 (b–e) from at/at or R26R/+; Tg.Hoxb6-Cre/+ mice (the latter were stained with X-Gal), as described in Materials and Methods. For purposes of comparison, images were proportionally scaled. The boundary of X-Gal staining marks dermis derived from lateral plate versus dermis derived from mesoderm (the lateral somitic frontier) and lies more dorsal than the at/at pigmentation boundary. (B) Quantitation of mean (± SEM) dorsal pigmentation area (n = 5) and somite-derived dermis area (n = 3) shows a significant difference (p < 0.005, t-test). (C) RNA in situ hybridization showing that Tbx15 expression at E11.5 is complementary to En1 expression on the flank (scale bars = 200 μm). The arrow indicates the boundary between the expression domains of the two genes. Because the pigmentation boundary lies in register with the limb–body wall junction (see Figure 2), we wondered whether mechanisms used for dorsoventral limb patterning might be related to those used to establish the pigmentation boundary.
T7284	35818-35825	IN	denotes	Because
T7285	35852-35856	VBZ	denotes	lies
T7286	35826-35829	DT	denotes	the
T7287	35843-35851	NN	denotes	boundary
T7288	35830-35842	NN	denotes	pigmentation
T7289	35921-35929	VBD	denotes	wondered
T7290	35857-35859	IN	denotes	in
T7291	35860-35868	NN	denotes	register
T7292	35869-35873	IN	denotes	with
T7293	35874-35877	DT	denotes	the
T7294	35893-35901	NN	denotes	junction
T7295	35878-35882	NN	denotes	limb
T7296	35882-35883	HYPH	denotes	–
T7297	35883-35887	NN	denotes	body
T7298	35888-35892	NN	denotes	wall
T7299	35902-35903	-LRB-	denotes	(
T7300	35903-35906	VB	denotes	see
T7301	35907-35913	NN	denotes	Figure
T7302	35914-35915	CD	denotes	2
T7303	35915-35916	-RRB-	denotes	)
T7304	35916-35918	,	denotes	,
T7305	35918-35920	PRP	denotes	we
T7306	35930-35937	IN	denotes	whether
T7307	35993-35995	VB	denotes	be
T7308	35938-35948	NNS	denotes	mechanisms
T7309	35949-35953	VBN	denotes	used
T7310	35954-35957	IN	denotes	for
T7311	35958-35970	JJ	denotes	dorsoventral
T7312	35976-35986	NN	denotes	patterning
T7313	35971-35975	NN	denotes	limb
T7314	35987-35992	MD	denotes	might
T7315	35996-36003	JJ	denotes	related
T7316	36004-36006	IN	denotes	to
T7317	36007-36012	DT	denotes	those
T7318	36013-36017	VBN	denotes	used
T7319	36018-36020	TO	denotes	to
T7320	36021-36030	VB	denotes	establish
T7321	36031-36034	DT	denotes	the
T7322	36048-36056	NN	denotes	boundary
T7323	36035-36047	NN	denotes	pigmentation
T7324	36056-36057	.	denotes	.
T7325	36057-36247	sentence	denotes	In the developing limb, Engrailed1 (En1), Wnt7a, and Lmx1b are part of a network whose restricted domains of expression help to establish dorsoventral identity (reviewed in Niswander 2003).
T7326	36058-36060	IN	denotes	In
T7327	36117-36120	VBP	denotes	are
T7328	36061-36064	DT	denotes	the
T7329	36076-36080	NN	denotes	limb
T7330	36065-36075	VBG	denotes	developing
T7331	36080-36082	,	denotes	,
T7332	36082-36092	NN	denotes	Engrailed1
T7333	36093-36094	-LRB-	denotes	(
T7334	36094-36097	NN	denotes	En1
T7335	36097-36098	-RRB-	denotes	)
T7336	36098-36100	,	denotes	,
T7337	36100-36105	NN	denotes	Wnt7a
T7338	36105-36107	,	denotes	,
T7339	36107-36110	CC	denotes	and
T7340	36111-36116	NN	denotes	Lmx1b
T7341	36121-36125	NN	denotes	part
T7342	36126-36128	IN	denotes	of
T7343	36129-36130	DT	denotes	a
T7344	36131-36138	NN	denotes	network
T7345	36139-36144	WP$	denotes	whose
T7346	36156-36163	NNS	denotes	domains
T7347	36145-36155	JJ	denotes	restricted
T7348	36178-36182	VBP	denotes	help
T7349	36164-36166	IN	denotes	of
T7350	36167-36177	NN	denotes	expression
T7351	36183-36185	TO	denotes	to
T7352	36186-36195	VB	denotes	establish
T7353	36196-36208	JJ	denotes	dorsoventral
T7354	36209-36217	NN	denotes	identity
T7355	36218-36219	-LRB-	denotes	(
T7356	36219-36227	VBN	denotes	reviewed
T7357	36228-36230	IN	denotes	in
T7358	36231-36240	NNP	denotes	Niswander
T7359	36241-36245	CD	denotes	2003
T7360	36245-36246	-RRB-	denotes	)
T7361	36246-36247	.	denotes	.
T7362	36247-36442	sentence	denotes	En1 is transiently expressed in the developing flank; at E11.5, transverse abdominal sections reveal domains in the neural tube, somite-derived mesenchyme, and the ventral body wall (Figure 8C).
T7363	36248-36251	NN	denotes	En1
T7364	36267-36276	VBN	denotes	expressed
T7365	36252-36254	VBZ	denotes	is
T7366	36255-36266	RB	denotes	transiently
T7367	36342-36348	VBP	denotes	reveal
T7368	36277-36279	IN	denotes	in
T7369	36280-36283	DT	denotes	the
T7370	36295-36300	NN	denotes	flank
T7371	36284-36294	VBG	denotes	developing
T7372	36300-36301	:	denotes	;
T7373	36302-36304	IN	denotes	at
T7374	36305-36310	NN	denotes	E11.5
T7375	36310-36312	,	denotes	,
T7376	36312-36322	JJ	denotes	transverse
T7377	36333-36341	NNS	denotes	sections
T7378	36323-36332	JJ	denotes	abdominal
T7379	36349-36356	NNS	denotes	domains
T7380	36357-36359	IN	denotes	in
T7381	36360-36363	DT	denotes	the
T7382	36371-36375	NN	denotes	tube
T7383	36364-36370	JJ	denotes	neural
T7384	36375-36377	,	denotes	,
T7385	36377-36383	NN	denotes	somite
T7386	36384-36391	VBN	denotes	derived
T7387	36383-36384	HYPH	denotes	-
T7388	36392-36402	NN	denotes	mesenchyme
T7389	36402-36404	,	denotes	,
T7390	36404-36407	CC	denotes	and
T7391	36408-36411	DT	denotes	the
T7392	36425-36429	NN	denotes	wall
T7393	36412-36419	JJ	denotes	ventral
T7394	36420-36424	NN	denotes	body
T7395	36430-36431	-LRB-	denotes	(
T7396	36431-36437	NN	denotes	Figure
T7397	36438-36440	CD	denotes	8C
T7398	36440-36441	-RRB-	denotes	)
T7399	36441-36442	.	denotes	.
T7400	36442-36753	sentence	denotes	An adjacent section hybridized with Tbx15 reveals a complementary pattern in the flank, which provides additional evidence for developmental mechanisms that establish a pigmentation boundary entirely within lateral plate mesoderm and independent of lineage restrictions imposed by the lateral somitic frontier.
T7401	36443-36445	DT	denotes	An
T7402	36455-36462	NN	denotes	section
T7403	36446-36454	JJ	denotes	adjacent
T7404	36485-36492	VBZ	denotes	reveals
T7405	36463-36473	VBN	denotes	hybridized
T7406	36474-36478	IN	denotes	with
T7407	36479-36484	NN	denotes	Tbx15
T7408	36493-36494	DT	denotes	a
T7409	36509-36516	NN	denotes	pattern
T7410	36495-36508	JJ	denotes	complementary
T7411	36517-36519	IN	denotes	in
T7412	36520-36523	DT	denotes	the
T7413	36524-36529	NN	denotes	flank
T7414	36529-36531	,	denotes	,
T7415	36531-36536	WDT	denotes	which
T7416	36537-36545	VBZ	denotes	provides
T7417	36546-36556	JJ	denotes	additional
T7418	36557-36565	NN	denotes	evidence
T7419	36566-36569	IN	denotes	for
T7420	36570-36583	JJ	denotes	developmental
T7421	36584-36594	NNS	denotes	mechanisms
T7422	36595-36599	WDT	denotes	that
T7423	36600-36609	VBP	denotes	establish
T7424	36610-36611	DT	denotes	a
T7425	36625-36633	NN	denotes	boundary
T7426	36612-36624	NN	denotes	pigmentation
T7427	36634-36642	RB	denotes	entirely
T7428	36643-36649	IN	denotes	within
T7429	36650-36657	JJ	denotes	lateral
T7430	36658-36663	NN	denotes	plate
T7431	36664-36672	NN	denotes	mesoderm
T7432	36673-36676	CC	denotes	and
T7433	36677-36688	JJ	denotes	independent
T7434	36689-36691	IN	denotes	of
T7435	36692-36699	NN	denotes	lineage
T7436	36700-36712	NNS	denotes	restrictions
T7437	36713-36720	VBN	denotes	imposed
T7438	36721-36723	IN	denotes	by
T7439	36724-36727	DT	denotes	the
T7440	36744-36752	NN	denotes	frontier
T7441	36728-36735	JJ	denotes	lateral
T7442	36736-36743	JJ	denotes	somitic
T7443	36752-36753	.	denotes	.
T7563	36766-36773	JJ	denotes	Several
T7564	36774-36783	NNS	denotes	mutations
T7565	36804-36814	VBN	denotes	identified
T7566	36784-36787	CC	denotes	and
T7567	36788-36793	NNS	denotes	genes
T7568	36794-36798	VBP	denotes	have
T7569	36799-36803	VBN	denotes	been
T7570	36815-36819	WDT	denotes	that
T7571	36820-36826	VBP	denotes	affect
T7572	36827-36830	DT	denotes	the
T7573	36831-36838	NN	denotes	pattern
T7574	36839-36841	IN	denotes	of
T7575	36842-36846	NN	denotes	hair
T7576	36847-36855	NN	denotes	follicle
T7577	36856-36867	NN	denotes	development
T7578	36867-36869	,	denotes	,
T7579	36869-36872	CC	denotes	but
T7580	36873-36878	NN	denotes	Tbx15
T7581	36879-36881	VBZ	denotes	is
T7582	36882-36885	DT	denotes	the
T7583	36891-36895	NN	denotes	gene
T7584	36886-36890	JJ	denotes	only
T7585	36896-36898	IN	denotes	of
T7586	36908-36911	VBP	denotes	are
T7587	36899-36904	WDT	denotes	which
T7588	36905-36907	PRP	denotes	we
T7589	36912-36917	JJ	denotes	aware
T7590	36918-36922	WDT	denotes	that
T7591	36923-36930	VBZ	denotes	affects
T7592	36931-36934	DT	denotes	the
T7593	36935-36942	NN	denotes	pattern
T7594	36943-36945	IN	denotes	of
T7595	36946-36950	NN	denotes	hair
T7596	36951-36963	NN	denotes	pigmentation
T7597	36964-36966	IN	denotes	in
T7598	36967-36976	JJ	denotes	different
T7599	36982-36989	NNS	denotes	regions
T7600	36977-36981	NN	denotes	body
T7601	36989-36990	.	denotes	.
T7602	36990-37254	sentence	denotes	Ventral areas that normally produce yellow hair in the trunk, limbs, and craniofacial regions are expanded in deH/deH mice and, in the trunk at least, represent inappropriate dorsal expression of an Agouti mRNA isoform that is normally restricted to ventral skin.
T7603	36991-36998	JJ	denotes	Ventral
T7604	36999-37004	NNS	denotes	areas
T7605	37089-37097	VBN	denotes	expanded
T7606	37005-37009	WDT	denotes	that
T7607	37019-37026	VBP	denotes	produce
T7608	37010-37018	RB	denotes	normally
T7609	37027-37033	JJ	denotes	yellow
T7610	37034-37038	NN	denotes	hair
T7611	37039-37041	IN	denotes	in
T7612	37042-37045	DT	denotes	the
T7613	37046-37051	NN	denotes	trunk
T7614	37051-37053	,	denotes	,
T7615	37053-37058	NNS	denotes	limbs
T7616	37058-37060	,	denotes	,
T7617	37060-37063	CC	denotes	and
T7618	37064-37076	JJ	denotes	craniofacial
T7619	37077-37084	NNS	denotes	regions
T7620	37085-37088	VBP	denotes	are
T7621	37098-37100	IN	denotes	in
T7622	37101-37104	NN	denotes	deH
T7623	37105-37108	NN	denotes	deH
T7624	37104-37105	SYM	denotes	/
T7625	37109-37113	NNS	denotes	mice
T7626	37114-37117	CC	denotes	and
T7627	37117-37119	,	denotes	,
T7628	37119-37121	IN	denotes	in
T7629	37142-37151	VBP	denotes	represent
T7630	37122-37125	DT	denotes	the
T7631	37126-37131	NN	denotes	trunk
T7632	37132-37134	RB	denotes	at
T7633	37135-37140	RBS	denotes	least
T7634	37140-37142	,	denotes	,
T7635	37152-37165	JJ	denotes	inappropriate
T7636	37173-37183	NN	denotes	expression
T7637	37166-37172	JJ	denotes	dorsal
T7638	37184-37186	IN	denotes	of
T7639	37187-37189	DT	denotes	an
T7640	37202-37209	NN	denotes	isoform
T7641	37190-37196	NN	denotes	Agouti
T7642	37197-37201	NN	denotes	mRNA
T7643	37210-37214	WDT	denotes	that
T7644	37227-37237	VBN	denotes	restricted
T7645	37215-37217	VBZ	denotes	is
T7646	37218-37226	RB	denotes	normally
T7647	37238-37240	IN	denotes	to
T7648	37241-37248	JJ	denotes	ventral
T7649	37249-37253	NN	denotes	skin
T7650	37253-37254	.	denotes	.
T7651	37254-37485	sentence	denotes	The deH allele is caused by a large deletion that removes most of the Tbx15 coding sequence, but the pleiotropic phenotype is caused by a simple loss of function for Tbx15 rather than a dominant-negative or contiguous gene effect.
T7652	37255-37258	DT	denotes	The
T7653	37263-37269	NN	denotes	allele
T7654	37259-37262	NN	denotes	deH
T7655	37273-37279	VBN	denotes	caused
T7656	37270-37272	VBZ	denotes	is
T7657	37280-37282	IN	denotes	by
T7658	37283-37284	DT	denotes	a
T7659	37291-37299	NN	denotes	deletion
T7660	37285-37290	JJ	denotes	large
T7661	37300-37304	WDT	denotes	that
T7662	37305-37312	VBZ	denotes	removes
T7663	37313-37317	JJS	denotes	most
T7664	37318-37320	IN	denotes	of
T7665	37321-37324	DT	denotes	the
T7666	37338-37346	NN	denotes	sequence
T7667	37325-37330	NN	denotes	Tbx15
T7668	37331-37337	NN	denotes	coding
T7669	37346-37348	,	denotes	,
T7670	37348-37351	CC	denotes	but
T7671	37352-37355	DT	denotes	the
T7672	37368-37377	NN	denotes	phenotype
T7673	37356-37367	JJ	denotes	pleiotropic
T7674	37381-37387	VBN	denotes	caused
T7675	37378-37380	VBZ	denotes	is
T7676	37388-37390	IN	denotes	by
T7677	37391-37392	DT	denotes	a
T7678	37400-37404	NN	denotes	loss
T7679	37393-37399	JJ	denotes	simple
T7680	37405-37407	IN	denotes	of
T7681	37408-37416	NN	denotes	function
T7682	37417-37420	IN	denotes	for
T7683	37421-37426	NN	denotes	Tbx15
T7684	37427-37433	RB	denotes	rather
T7685	37434-37438	IN	denotes	than
T7686	37439-37440	DT	denotes	a
T7687	37478-37484	NN	denotes	effect
T7688	37441-37449	JJ	denotes	dominant
T7689	37450-37458	JJ	denotes	negative
T7690	37449-37450	HYPH	denotes	-
T7691	37459-37461	CC	denotes	or
T7692	37462-37472	JJ	denotes	contiguous
T7693	37473-37477	NN	denotes	gene
T7694	37484-37485	.	denotes	.
T7695	37485-37747	sentence	denotes	In particular, there is no heterozygous phenotype, no other genes lie within or close to the deletion breakpoints, and the expression pattern of Tbx15 is consistent with the spectrum of phenotypic abnormalities in both the original de allele and the deH allele.
T7696	37486-37488	IN	denotes	In
T7697	37507-37509	VBZ	denotes	is
T7698	37489-37499	JJ	denotes	particular
T7699	37499-37501	,	denotes	,
T7700	37501-37506	EX	denotes	there
T7701	37510-37512	DT	denotes	no
T7702	37526-37535	NN	denotes	phenotype
T7703	37513-37525	JJ	denotes	heterozygous
T7704	37535-37537	,	denotes	,
T7705	37537-37539	DT	denotes	no
T7706	37546-37551	NNS	denotes	genes
T7707	37540-37545	JJ	denotes	other
T7708	37552-37555	VBP	denotes	lie
T7709	37556-37562	IN	denotes	within
T7710	37563-37565	CC	denotes	or
T7711	37566-37571	RB	denotes	close
T7712	37588-37599	NNS	denotes	breakpoints
T7713	37572-37574	IN	denotes	to
T7714	37575-37578	DT	denotes	the
T7715	37579-37587	NN	denotes	deletion
T7716	37599-37601	,	denotes	,
T7717	37601-37604	CC	denotes	and
T7718	37605-37608	DT	denotes	the
T7719	37620-37627	NN	denotes	pattern
T7720	37609-37619	NN	denotes	expression
T7721	37637-37639	VBZ	denotes	is
T7722	37628-37630	IN	denotes	of
T7723	37631-37636	NN	denotes	Tbx15
T7724	37640-37650	JJ	denotes	consistent
T7725	37651-37655	IN	denotes	with
T7726	37656-37659	DT	denotes	the
T7727	37660-37668	NN	denotes	spectrum
T7728	37669-37671	IN	denotes	of
T7729	37672-37682	JJ	denotes	phenotypic
T7730	37683-37696	NNS	denotes	abnormalities
T7731	37697-37699	IN	denotes	in
T7732	37700-37704	CC	denotes	both
T7733	37721-37727	NN	denotes	allele
T7734	37705-37708	DT	denotes	the
T7735	37709-37717	JJ	denotes	original
T7736	37718-37720	NN	denotes	de
T7737	37728-37731	CC	denotes	and
T7738	37732-37735	DT	denotes	the
T7739	37740-37746	NN	denotes	allele
T7740	37736-37739	NN	denotes	deH
T7741	37746-37747	.	denotes	.
T7742	37747-37811	sentence	denotes	Finally, a Tbx15 targeted allele has the same phenotype as deH.
T7743	37748-37755	RB	denotes	Finally
T7744	37781-37784	VBZ	denotes	has
T7745	37755-37757	,	denotes	,
T7746	37757-37758	DT	denotes	a
T7747	37774-37780	NN	denotes	allele
T7748	37759-37764	NN	denotes	Tbx15
T7749	37765-37773	VBN	denotes	targeted
T7750	37785-37788	DT	denotes	the
T7751	37794-37803	NN	denotes	phenotype
T7752	37789-37793	JJ	denotes	same
T7753	37804-37806	IN	denotes	as
T7754	37807-37810	NN	denotes	deH
T7755	37810-37811	.	denotes	.
T7756	37812-38009	sentence	denotes	Our results suggest that patterned expression of Tbx15 provides an instructional cue required to establish the future identity of dorsal dermis with regard to pigmentary and hair length patterning.
T7757	37812-37815	PRP$	denotes	Our
T7758	37816-37823	NNS	denotes	results
T7759	37824-37831	VBP	denotes	suggest
T7760	37832-37836	IN	denotes	that
T7761	37867-37875	VBZ	denotes	provides
T7762	37837-37846	VBN	denotes	patterned
T7763	37847-37857	NN	denotes	expression
T7764	37858-37860	IN	denotes	of
T7765	37861-37866	NN	denotes	Tbx15
T7766	37876-37878	DT	denotes	an
T7767	37893-37896	NN	denotes	cue
T7768	37879-37892	JJ	denotes	instructional
T7769	37897-37905	VBN	denotes	required
T7770	37906-37908	TO	denotes	to
T7771	37909-37918	VB	denotes	establish
T7772	37919-37922	DT	denotes	the
T7773	37930-37938	NN	denotes	identity
T7774	37923-37929	JJ	denotes	future
T7775	37939-37941	IN	denotes	of
T7776	37942-37948	JJ	denotes	dorsal
T7777	37949-37955	NN	denotes	dermis
T7778	37956-37960	IN	denotes	with
T7779	37961-37967	NN	denotes	regard
T7780	37968-37970	IN	denotes	to
T7781	37971-37981	JJ	denotes	pigmentary
T7782	37998-38008	NN	denotes	patterning
T7783	37982-37985	CC	denotes	and
T7784	37986-37990	NN	denotes	hair
T7785	37991-37997	NN	denotes	length
T7786	38008-38009	.	denotes	.
T7787	38009-38188	sentence	denotes	The ventral edge of Tbx15 expression in the developing flank does not correspond to a known lineage compartment, but, like limb development, occurs within lateral plate mesoderm.
T7788	38010-38013	DT	denotes	The
T7789	38022-38026	NN	denotes	edge
T7790	38014-38021	JJ	denotes	ventral
T7791	38080-38090	VB	denotes	correspond
T7792	38027-38029	IN	denotes	of
T7793	38030-38035	NN	denotes	Tbx15
T7794	38036-38046	NN	denotes	expression
T7795	38047-38049	IN	denotes	in
T7796	38050-38053	DT	denotes	the
T7797	38065-38070	NN	denotes	flank
T7798	38054-38064	VBG	denotes	developing
T7799	38071-38075	VBZ	denotes	does
T7800	38076-38079	RB	denotes	not
T7801	38091-38093	IN	denotes	to
T7802	38094-38095	DT	denotes	a
T7803	38110-38121	NN	denotes	compartment
T7804	38096-38101	VBN	denotes	known
T7805	38102-38109	NN	denotes	lineage
T7806	38121-38123	,	denotes	,
T7807	38123-38126	CC	denotes	but
T7808	38126-38128	,	denotes	,
T7809	38128-38132	IN	denotes	like
T7810	38151-38157	VBZ	denotes	occurs
T7811	38133-38137	NN	denotes	limb
T7812	38138-38149	NN	denotes	development
T7813	38149-38151	,	denotes	,
T7814	38158-38164	IN	denotes	within
T7815	38165-38172	JJ	denotes	lateral
T7816	38173-38178	NN	denotes	plate
T7817	38179-38187	NN	denotes	mesoderm
T7818	38187-38188	.	denotes	.
T7819	38188-38406	sentence	denotes	These findings represent a novel role for T-box gene action in embryonic development and provide evidence for a previously unappreciated complexity to acquisition of dorsoventral positional identity in mammalian skin.
T7820	38189-38194	DT	denotes	These
T7821	38195-38203	NNS	denotes	findings
T7822	38204-38213	VBP	denotes	represent
T7823	38214-38215	DT	denotes	a
T7824	38222-38226	NN	denotes	role
T7825	38216-38221	JJ	denotes	novel
T7826	38227-38230	IN	denotes	for
T7827	38231-38232	NN	denotes	T
T7828	38233-38236	NN	denotes	box
T7829	38232-38233	HYPH	denotes	-
T7830	38242-38248	NN	denotes	action
T7831	38237-38241	NN	denotes	gene
T7832	38249-38251	IN	denotes	in
T7833	38252-38261	JJ	denotes	embryonic
T7834	38262-38273	NN	denotes	development
T7835	38274-38277	CC	denotes	and
T7836	38278-38285	VBP	denotes	provide
T7837	38286-38294	NN	denotes	evidence
T7838	38295-38298	IN	denotes	for
T7839	38299-38300	DT	denotes	a
T7840	38326-38336	NN	denotes	complexity
T7841	38301-38311	RB	denotes	previously
T7842	38312-38325	JJ	denotes	unappreciated
T7843	38337-38339	IN	denotes	to
T7844	38340-38351	NN	denotes	acquisition
T7845	38352-38354	IN	denotes	of
T7846	38355-38367	JJ	denotes	dorsoventral
T7847	38379-38387	NN	denotes	identity
T7848	38368-38378	JJ	denotes	positional
T7849	38388-38390	IN	denotes	in
T7850	38391-38400	JJ	denotes	mammalian
T7851	38401-38405	NN	denotes	skin
T7852	38405-38406	.	denotes	.
T7946	38408-38416	JJ	denotes	Distinct
T7947	38429-38436	NNS	denotes	Regions
T7948	38417-38428	JJ	denotes	Morphologic
T7949	38437-38446	VBP	denotes	Represent
T7950	38447-38450	DT	denotes	the
T7951	38451-38454	NN	denotes	Sum
T7952	38455-38457	IN	denotes	of
T7953	38458-38467	JJ	denotes	Different
T7954	38468-38477	NNS	denotes	Gradients
T7955	38477-38731	sentence	denotes	The visual boundary between dorsal and ventral skin in at/at mice is reminiscent of other systems in which adjacent compartments enforce a binary choice between alternative patterns of gene expression and cell fate (reviewed in Dahmann and Basler 1999).
T7956	38478-38481	DT	denotes	The
T7957	38489-38497	NN	denotes	boundary
T7958	38482-38488	JJ	denotes	visual
T7959	38544-38546	VBZ	denotes	is
T7960	38498-38505	IN	denotes	between
T7961	38506-38512	JJ	denotes	dorsal
T7962	38525-38529	NN	denotes	skin
T7963	38513-38516	CC	denotes	and
T7964	38517-38524	JJ	denotes	ventral
T7965	38530-38532	IN	denotes	in
T7966	38533-38535	NN	denotes	at
T7967	38536-38538	NN	denotes	at
T7968	38535-38536	SYM	denotes	/
T7969	38539-38543	NNS	denotes	mice
T7970	38547-38558	JJ	denotes	reminiscent
T7971	38559-38561	IN	denotes	of
T7972	38562-38567	JJ	denotes	other
T7973	38568-38575	NNS	denotes	systems
T7974	38576-38578	IN	denotes	in
T7975	38607-38614	VBP	denotes	enforce
T7976	38579-38584	WDT	denotes	which
T7977	38585-38593	JJ	denotes	adjacent
T7978	38594-38606	NNS	denotes	compartments
T7979	38615-38616	DT	denotes	a
T7980	38624-38630	NN	denotes	choice
T7981	38617-38623	JJ	denotes	binary
T7982	38631-38638	IN	denotes	between
T7983	38639-38650	JJ	denotes	alternative
T7984	38651-38659	NNS	denotes	patterns
T7985	38660-38662	IN	denotes	of
T7986	38663-38667	NN	denotes	gene
T7987	38668-38678	NN	denotes	expression
T7988	38679-38682	CC	denotes	and
T7989	38683-38687	NN	denotes	cell
T7990	38688-38692	NN	denotes	fate
T7991	38693-38694	-LRB-	denotes	(
T7992	38694-38702	VBN	denotes	reviewed
T7993	38703-38705	IN	denotes	in
T7994	38706-38713	NNP	denotes	Dahmann
T7995	38714-38717	CC	denotes	and
T7996	38718-38724	NNP	denotes	Basler
T7997	38725-38729	CD	denotes	1999
T7998	38729-38730	-RRB-	denotes	)
T7999	38730-38731	.	denotes	.
T8000	38731-38987	sentence	denotes	However, Agouti mRNA in both embryonic and postnatal skin is distributed along a gradient whose dorsal boundary is indistinct and overlaps with two additional gradients recognized by their effects on hair length and histochemical staining for melanocytes.
T8001	38732-38739	RB	denotes	However
T8002	38793-38804	VBN	denotes	distributed
T8003	38739-38741	,	denotes	,
T8004	38741-38747	NN	denotes	Agouti
T8005	38748-38752	NN	denotes	mRNA
T8006	38753-38755	IN	denotes	in
T8007	38756-38760	CC	denotes	both
T8008	38761-38770	JJ	denotes	embryonic
T8009	38785-38789	NN	denotes	skin
T8010	38771-38774	CC	denotes	and
T8011	38775-38784	JJ	denotes	postnatal
T8012	38790-38792	VBZ	denotes	is
T8013	38805-38810	IN	denotes	along
T8014	38811-38812	DT	denotes	a
T8015	38813-38821	NN	denotes	gradient
T8016	38822-38827	WP$	denotes	whose
T8017	38835-38843	NN	denotes	boundary
T8018	38828-38834	JJ	denotes	dorsal
T8019	38844-38846	VBZ	denotes	is
T8020	38847-38857	JJ	denotes	indistinct
T8021	38858-38861	CC	denotes	and
T8022	38862-38870	VBZ	denotes	overlaps
T8023	38871-38875	IN	denotes	with
T8024	38876-38879	CD	denotes	two
T8025	38891-38900	NNS	denotes	gradients
T8026	38880-38890	JJ	denotes	additional
T8027	38901-38911	VBN	denotes	recognized
T8028	38912-38914	IN	denotes	by
T8029	38915-38920	PRP$	denotes	their
T8030	38921-38928	NNS	denotes	effects
T8031	38929-38931	IN	denotes	on
T8032	38932-38936	NN	denotes	hair
T8033	38937-38943	NN	denotes	length
T8034	38944-38947	CC	denotes	and
T8035	38948-38961	JJ	denotes	histochemical
T8036	38962-38970	NN	denotes	staining
T8037	38971-38974	IN	denotes	for
T8038	38975-38986	NNS	denotes	melanocytes
T8039	38986-38987	.	denotes	.
T8040	38987-39156	sentence	denotes	The three gradients are close but not congruent, and it is their proximity that gives rise to the superficial distinction between dorsal and ventral skin of at/at mice.
T8041	38988-38991	DT	denotes	The
T8042	38998-39007	NNS	denotes	gradients
T8043	38992-38997	CD	denotes	three
T8044	39008-39011	VBP	denotes	are
T8045	39012-39017	JJ	denotes	close
T8046	39018-39021	CC	denotes	but
T8047	39022-39025	RB	denotes	not
T8048	39026-39035	JJ	denotes	congruent
T8049	39035-39037	,	denotes	,
T8050	39037-39040	CC	denotes	and
T8051	39041-39043	PRP	denotes	it
T8052	39044-39046	VBZ	denotes	is
T8053	39047-39052	PRP$	denotes	their
T8054	39053-39062	NN	denotes	proximity
T8055	39063-39067	WDT	denotes	that
T8056	39068-39073	VBZ	denotes	gives
T8057	39074-39078	NN	denotes	rise
T8058	39079-39081	IN	denotes	to
T8059	39082-39085	DT	denotes	the
T8060	39098-39109	NN	denotes	distinction
T8061	39086-39097	JJ	denotes	superficial
T8062	39110-39117	IN	denotes	between
T8063	39118-39124	JJ	denotes	dorsal
T8064	39137-39141	NN	denotes	skin
T8065	39125-39128	CC	denotes	and
T8066	39129-39136	JJ	denotes	ventral
T8067	39142-39144	IN	denotes	of
T8068	39145-39147	NN	denotes	at
T8069	39148-39150	NN	denotes	at
T8070	39147-39148	SYM	denotes	/
T8071	39151-39155	NNS	denotes	mice
T8072	39155-39156	.	denotes	.
T8073	39156-39344	sentence	denotes	Indeed, slight differences between the regions of transition for pigment-type switching and pigment content give rise to a subtle yellow stripe along the flank (see Figures 1, 2, and 9A).
T8074	39157-39163	RB	denotes	Indeed
T8075	39265-39269	VBP	denotes	give
T8076	39163-39165	,	denotes	,
T8077	39165-39171	JJ	denotes	slight
T8078	39172-39183	NNS	denotes	differences
T8079	39184-39191	IN	denotes	between
T8080	39192-39195	DT	denotes	the
T8081	39196-39203	NNS	denotes	regions
T8082	39204-39206	IN	denotes	of
T8083	39207-39217	NN	denotes	transition
T8084	39218-39221	IN	denotes	for
T8085	39222-39229	NN	denotes	pigment
T8086	39230-39234	NN	denotes	type
T8087	39229-39230	HYPH	denotes	-
T8088	39235-39244	NN	denotes	switching
T8089	39245-39248	CC	denotes	and
T8090	39249-39256	NN	denotes	pigment
T8091	39257-39264	NN	denotes	content
T8092	39270-39274	NN	denotes	rise
T8093	39275-39277	IN	denotes	to
T8094	39278-39279	DT	denotes	a
T8095	39294-39300	NN	denotes	stripe
T8096	39280-39286	JJ	denotes	subtle
T8097	39287-39293	JJ	denotes	yellow
T8098	39301-39306	IN	denotes	along
T8099	39307-39310	DT	denotes	the
T8100	39311-39316	NN	denotes	flank
T8101	39317-39318	-LRB-	denotes	(
T8102	39318-39321	VB	denotes	see
T8103	39322-39329	NNS	denotes	Figures
T8104	39330-39331	CD	denotes	1
T8105	39331-39333	,	denotes	,
T8106	39333-39334	CD	denotes	2
T8107	39334-39336	,	denotes	,
T8108	39336-39339	CC	denotes	and
T8109	39340-39342	CD	denotes	9A
T8110	39342-39343	-RRB-	denotes	)
T8111	39343-39344	.	denotes	.
T8112	39344-39610	sentence	denotes	Levels of Agouti mRNA remain high throughout the entire ventrum, but hair pigment content is reduced, giving rise to a cream-colored region in the ventrum that, depending on age and genetic backgrounds, may appear more or less distinct from the yellow flank stripe.
T8113	39345-39351	NNS	denotes	Levels
T8114	39367-39373	VBP	denotes	remain
T8115	39352-39354	IN	denotes	of
T8116	39355-39361	NN	denotes	Agouti
T8117	39362-39366	NN	denotes	mRNA
T8118	39374-39378	JJ	denotes	high
T8119	39379-39389	IN	denotes	throughout
T8120	39390-39393	DT	denotes	the
T8121	39401-39408	NN	denotes	ventrum
T8122	39394-39400	JJ	denotes	entire
T8123	39408-39410	,	denotes	,
T8124	39410-39413	CC	denotes	but
T8125	39414-39418	NN	denotes	hair
T8126	39427-39434	NN	denotes	content
T8127	39419-39426	NN	denotes	pigment
T8128	39438-39445	VBN	denotes	reduced
T8129	39435-39437	VBZ	denotes	is
T8130	39445-39447	,	denotes	,
T8131	39447-39453	VBG	denotes	giving
T8132	39454-39458	NN	denotes	rise
T8133	39459-39461	IN	denotes	to
T8134	39462-39463	DT	denotes	a
T8135	39478-39484	NN	denotes	region
T8136	39464-39469	NN	denotes	cream
T8137	39470-39477	VBN	denotes	colored
T8138	39469-39470	HYPH	denotes	-
T8139	39485-39487	IN	denotes	in
T8140	39488-39491	DT	denotes	the
T8141	39492-39499	NN	denotes	ventrum
T8142	39500-39504	WDT	denotes	that
T8143	39552-39558	VB	denotes	appear
T8144	39504-39506	,	denotes	,
T8145	39506-39515	VBG	denotes	depending
T8146	39516-39518	IN	denotes	on
T8147	39519-39522	NN	denotes	age
T8148	39523-39526	CC	denotes	and
T8149	39527-39534	JJ	denotes	genetic
T8150	39535-39546	NNS	denotes	backgrounds
T8151	39546-39548	,	denotes	,
T8152	39548-39551	MD	denotes	may
T8153	39559-39563	RBR	denotes	more
T8154	39572-39580	JJ	denotes	distinct
T8155	39564-39566	CC	denotes	or
T8156	39567-39571	RBR	denotes	less
T8157	39581-39585	IN	denotes	from
T8158	39586-39589	DT	denotes	the
T8159	39603-39609	NN	denotes	stripe
T8160	39590-39596	JJ	denotes	yellow
T8161	39597-39602	NN	denotes	flank
T8162	39609-39610	.	denotes	.
T8163	39610-41130	sentence	denotes	Figure 9 Model for Acquisition of Dorsoventral Patterning in the Trunk and the Role of Tbx15 (A) A tricolor pigmentation pattern is generated by the combination of distinct mechanisms that affect distribution of Agouti mRNA and histochemical staining for melanocytes; effects of the latter mechanism by itself are evident in ae/ae mice (see Figure 1). In at/at mice, reduced hair melanocyte activity and high levels of Agouti mRNA in the ventrum lead to a cream color; as melanocyte activity gradually increases towards the dorsum, a lateral stripe is apparent on the flank. The distributions of Agouti mRNA and histochemical staining for melanocytes are both affected by Tbx15 and are externally evident by a widening of the lateral stripe and an increased proportion of total skin occupied by the cream-colored area. (B) The lateral yellow stripe in at/at mice lies at the same level as the limb dorsoventral boundary. As described in the text, we propose that distinct dorsoventral compartments in ectoderm of the trunk provide an instructional cue to the mesoderm, leading to expression of Tbx15 in dorsal trunk mesenchyme and acquisition of dorsal dermis character. In the absence of Tbx15, dorsal mesenchyme assumes ventral characteristics instead. Loss of Tbx15 affects dorsoventral transitions of hair length, pigment content, and expression of the ventral-specific Agouti isoform; however, the former two effects are subtle and contribute little, if at all, to the abnormal pigmentation of adult deH/deH mice.
T8164	40867-40871	NN	denotes	Loss
T8165	40881-40888	VBZ	denotes	affects
T8166	40872-40874	IN	denotes	of
T8167	40875-40880	NN	denotes	Tbx15
T8168	41034-41037	VBP	denotes	are
T8169	40889-40901	JJ	denotes	dorsoventral
T8170	40902-40913	NNS	denotes	transitions
T8171	40914-40916	IN	denotes	of
T8172	40917-40921	NN	denotes	hair
T8173	40922-40928	NN	denotes	length
T8174	40928-40930	,	denotes	,
T8175	40930-40937	NN	denotes	pigment
T8176	40938-40945	NN	denotes	content
T8177	40945-40947	,	denotes	,
T8178	40947-40950	CC	denotes	and
T8179	40951-40961	NN	denotes	expression
T8180	40962-40964	IN	denotes	of
T8181	40965-40968	DT	denotes	the
T8182	40993-41000	NN	denotes	isoform
T8183	40969-40976	JJ	denotes	ventral
T8184	40977-40985	JJ	denotes	specific
T8185	40976-40977	HYPH	denotes	-
T8186	40986-40992	NN	denotes	Agouti
T8187	41000-41001	:	denotes	;
T8188	41002-41009	RB	denotes	however
T8189	41009-41011	,	denotes	,
T8190	41011-41014	DT	denotes	the
T8191	41026-41033	NNS	denotes	effects
T8192	41015-41021	JJ	denotes	former
T8193	41022-41025	CD	denotes	two
T8194	41038-41044	JJ	denotes	subtle
T8195	41045-41048	CC	denotes	and
T8196	41049-41059	VBP	denotes	contribute
T8197	41060-41066	JJ	denotes	little
T8198	41066-41068	,	denotes	,
T8199	41074-41077	RB	denotes	all
T8200	41068-41070	IN	denotes	if
T8201	41071-41073	RB	denotes	at
T8202	41077-41079	,	denotes	,
T8203	41079-41081	IN	denotes	to
T8204	41082-41085	DT	denotes	the
T8205	41095-41107	NN	denotes	pigmentation
T8206	41086-41094	JJ	denotes	abnormal
T8207	41108-41110	IN	denotes	of
T8208	41111-41116	JJ	denotes	adult
T8209	41125-41129	NNS	denotes	mice
T8210	41117-41120	NN	denotes	deH
T8211	41121-41124	NN	denotes	deH
T8212	41120-41121	SYM	denotes	/
T8213	41129-41130	.	denotes	.
T8214	41130-41341	sentence	denotes	Thus, despite the abnormal pattern of dark skin in neonatal deH/deH mice (e.g., Figure 2D), the most obvious feature in adults is dorsal displacement of the “boundary” between black and yellow hair (Figure 9A).
T8215	41131-41135	RB	denotes	Thus
T8216	41258-41260	VBZ	denotes	is
T8217	41135-41137	,	denotes	,
T8218	41137-41144	IN	denotes	despite
T8219	41145-41148	DT	denotes	the
T8220	41158-41165	NN	denotes	pattern
T8221	41149-41157	JJ	denotes	abnormal
T8222	41166-41168	IN	denotes	of
T8223	41169-41173	JJ	denotes	dark
T8224	41174-41178	NN	denotes	skin
T8225	41179-41181	IN	denotes	in
T8226	41182-41190	JJ	denotes	neonatal
T8227	41199-41203	NNS	denotes	mice
T8228	41191-41194	NN	denotes	deH
T8229	41195-41198	NN	denotes	deH
T8230	41194-41195	SYM	denotes	/
T8231	41204-41205	-LRB-	denotes	(
T8232	41211-41217	NN	denotes	Figure
T8233	41205-41209	FW	denotes	e.g.
T8234	41209-41211	,	denotes	,
T8235	41218-41220	CD	denotes	2D
T8236	41220-41221	-RRB-	denotes	)
T8237	41221-41223	,	denotes	,
T8238	41223-41226	DT	denotes	the
T8239	41240-41247	NN	denotes	feature
T8240	41227-41231	RBS	denotes	most
T8241	41232-41239	JJ	denotes	obvious
T8242	41248-41250	IN	denotes	in
T8243	41251-41257	NNS	denotes	adults
T8244	41261-41267	JJ	denotes	dorsal
T8245	41268-41280	NN	denotes	displacement
T8246	41281-41283	IN	denotes	of
T8247	41284-41287	DT	denotes	the
T8248	41289-41297	NN	denotes	boundary
T8249	41288-41289	``	denotes	“
T8250	41297-41298	''	denotes	”
T8251	41299-41306	IN	denotes	between
T8252	41307-41312	JJ	denotes	black
T8253	41324-41328	NN	denotes	hair
T8254	41313-41316	CC	denotes	and
T8255	41317-41323	JJ	denotes	yellow
T8256	41329-41330	-LRB-	denotes	(
T8257	41330-41336	NN	denotes	Figure
T8258	41337-41339	CD	denotes	9A
T8259	41339-41340	-RRB-	denotes	)
T8260	41340-41341	.	denotes	.
T8496	41343-41351	NN	denotes	Genetics
T8497	41352-41354	IN	denotes	of
T8498	41355-41360	NN	denotes	Tbx15
T8499	41360-41656	sentence	denotes	Named for the presence of a DNA-binding domain first identified in the mouse Brachyury gene (haploinsufficiency causes a short tail), T box–containing genes have been identified as developmental regulators in a wide spectrum of tissues and multicellular organisms (reviewed in Papaioannou 2001).
T8500	41361-41366	VBN	denotes	Named
T8501	41528-41538	VBN	denotes	identified
T8502	41367-41370	IN	denotes	for
T8503	41371-41374	DT	denotes	the
T8504	41375-41383	NN	denotes	presence
T8505	41384-41386	IN	denotes	of
T8506	41387-41388	DT	denotes	a
T8507	41401-41407	NN	denotes	domain
T8508	41389-41392	NN	denotes	DNA
T8509	41393-41400	VBG	denotes	binding
T8510	41392-41393	HYPH	denotes	-
T8511	41408-41413	RB	denotes	first
T8512	41414-41424	VBN	denotes	identified
T8513	41425-41427	IN	denotes	in
T8514	41428-41431	DT	denotes	the
T8515	41448-41452	NN	denotes	gene
T8516	41432-41437	NN	denotes	mouse
T8517	41438-41447	NN	denotes	Brachyury
T8518	41453-41454	-LRB-	denotes	(
T8519	41473-41479	VBZ	denotes	causes
T8520	41454-41472	NN	denotes	haploinsufficiency
T8521	41480-41481	DT	denotes	a
T8522	41488-41492	NN	denotes	tail
T8523	41482-41487	JJ	denotes	short
T8524	41492-41493	-RRB-	denotes	)
T8525	41493-41495	,	denotes	,
T8526	41495-41496	NN	denotes	T
T8527	41497-41500	NN	denotes	box
T8528	41501-41511	VBG	denotes	containing
T8529	41500-41501	HYPH	denotes	–
T8530	41512-41517	NNS	denotes	genes
T8531	41518-41522	VBP	denotes	have
T8532	41523-41527	VBN	denotes	been
T8533	41539-41541	IN	denotes	as
T8534	41542-41555	JJ	denotes	developmental
T8535	41556-41566	NNS	denotes	regulators
T8536	41567-41569	IN	denotes	in
T8537	41570-41571	DT	denotes	a
T8538	41577-41585	NN	denotes	spectrum
T8539	41572-41576	JJ	denotes	wide
T8540	41586-41588	IN	denotes	of
T8541	41589-41596	NNS	denotes	tissues
T8542	41597-41600	CC	denotes	and
T8543	41601-41614	JJ	denotes	multicellular
T8544	41615-41624	NNS	denotes	organisms
T8545	41625-41626	-LRB-	denotes	(
T8546	41626-41634	VBN	denotes	reviewed
T8547	41635-41637	IN	denotes	in
T8548	41638-41649	NNP	denotes	Papaioannou
T8549	41650-41654	CD	denotes	2001
T8550	41654-41655	-RRB-	denotes	)
T8551	41655-41656	.	denotes	.
T8552	41656-41878	sentence	denotes	The Tbx15 subfamily, which also includes Tbx18 and Tbx22, is likely to have arisen during early chordate evolution since there is a single gene in amphioxus but no obvious homolog in the fly genome (Ruvinsky et al. 2000).
T8553	41657-41660	DT	denotes	The
T8554	41667-41676	NN	denotes	subfamily
T8555	41661-41666	NN	denotes	Tbx15
T8556	41715-41717	VBZ	denotes	is
T8557	41676-41678	,	denotes	,
T8558	41678-41683	WDT	denotes	which
T8559	41689-41697	VBZ	denotes	includes
T8560	41684-41688	RB	denotes	also
T8561	41698-41703	NN	denotes	Tbx18
T8562	41704-41707	CC	denotes	and
T8563	41708-41713	NN	denotes	Tbx22
T8564	41713-41715	,	denotes	,
T8565	41718-41724	JJ	denotes	likely
T8566	41725-41727	TO	denotes	to
T8567	41733-41739	VBN	denotes	arisen
T8568	41728-41732	VB	denotes	have
T8569	41740-41746	IN	denotes	during
T8570	41747-41752	JJ	denotes	early
T8571	41762-41771	NN	denotes	evolution
T8572	41753-41761	NN	denotes	chordate
T8573	41772-41777	IN	denotes	since
T8574	41784-41786	VBZ	denotes	is
T8575	41778-41783	EX	denotes	there
T8576	41787-41788	DT	denotes	a
T8577	41796-41800	NN	denotes	gene
T8578	41789-41795	JJ	denotes	single
T8579	41801-41803	IN	denotes	in
T8580	41804-41813	NN	denotes	amphioxus
T8581	41814-41817	CC	denotes	but
T8582	41818-41820	DT	denotes	no
T8583	41829-41836	NN	denotes	homolog
T8584	41821-41828	JJ	denotes	obvious
T8585	41837-41839	IN	denotes	in
T8586	41840-41843	DT	denotes	the
T8587	41848-41854	NN	denotes	genome
T8588	41844-41847	NN	denotes	fly
T8589	41855-41856	-LRB-	denotes	(
T8590	41856-41864	NNP	denotes	Ruvinsky
T8591	41865-41867	FW	denotes	et
T8592	41868-41871	FW	denotes	al.
T8593	41872-41876	CD	denotes	2000
T8594	41876-41877	-RRB-	denotes	)
T8595	41877-41878	.	denotes	.
T8596	41878-42248	sentence	denotes	Consistent with this relationship, the three genes are expressed in partially overlapping patterns that include anterior somites (Tbx18 and Tbx22), limb mesenchyme (Tbx15 and Tbx18), and craniofacial mesenchyme (all three genes, Tbx15 more broadly than Tbx18 or Tbx22) (Agulnik et al. 1998; Kraus et al. 2001; Braybrook et al. 2002; Bush et al. 2002; Herr et al. 2003).
T8597	41879-41889	JJ	denotes	Consistent
T8598	41934-41943	VBN	denotes	expressed
T8599	41890-41894	IN	denotes	with
T8600	41895-41899	DT	denotes	this
T8601	41900-41912	NN	denotes	relationship
T8602	41912-41914	,	denotes	,
T8603	41914-41917	DT	denotes	the
T8604	41924-41929	NNS	denotes	genes
T8605	41918-41923	CD	denotes	three
T8606	41930-41933	VBP	denotes	are
T8607	41944-41946	IN	denotes	in
T8608	41947-41956	RB	denotes	partially
T8609	41957-41968	VBG	denotes	overlapping
T8610	41969-41977	NNS	denotes	patterns
T8611	41978-41982	WDT	denotes	that
T8612	41983-41990	VBP	denotes	include
T8613	41991-41999	JJ	denotes	anterior
T8614	42000-42007	NNS	denotes	somites
T8615	42008-42009	-LRB-	denotes	(
T8616	42009-42014	NN	denotes	Tbx18
T8617	42015-42018	CC	denotes	and
T8618	42019-42024	NN	denotes	Tbx22
T8619	42024-42025	-RRB-	denotes	)
T8620	42025-42027	,	denotes	,
T8621	42027-42031	NN	denotes	limb
T8622	42032-42042	NN	denotes	mesenchyme
T8623	42043-42044	-LRB-	denotes	(
T8624	42044-42049	NN	denotes	Tbx15
T8625	42050-42053	CC	denotes	and
T8626	42054-42059	NN	denotes	Tbx18
T8627	42059-42060	-RRB-	denotes	)
T8628	42060-42062	,	denotes	,
T8629	42062-42065	CC	denotes	and
T8630	42066-42078	JJ	denotes	craniofacial
T8631	42079-42089	NN	denotes	mesenchyme
T8632	42090-42091	-LRB-	denotes	(
T8633	42101-42106	NNS	denotes	genes
T8634	42091-42094	DT	denotes	all
T8635	42095-42100	CD	denotes	three
T8636	42106-42108	,	denotes	,
T8637	42108-42113	NN	denotes	Tbx15
T8638	42114-42118	RBR	denotes	more
T8639	42119-42126	RB	denotes	broadly
T8640	42127-42131	IN	denotes	than
T8641	42132-42137	NN	denotes	Tbx18
T8642	42138-42140	CC	denotes	or
T8643	42141-42146	NN	denotes	Tbx22
T8644	42146-42147	-RRB-	denotes	)
T8645	42148-42149	-LRB-	denotes	(
T8646	42149-42156	NNP	denotes	Agulnik
T8647	42157-42159	FW	denotes	et
T8648	42160-42163	FW	denotes	al.
T8649	42164-42168	CD	denotes	1998
T8650	42168-42169	:	denotes	;
T8651	42170-42175	NNP	denotes	Kraus
T8652	42176-42178	FW	denotes	et
T8653	42179-42182	FW	denotes	al.
T8654	42183-42187	CD	denotes	2001
T8655	42187-42188	:	denotes	;
T8656	42189-42198	NNP	denotes	Braybrook
T8657	42199-42201	FW	denotes	et
T8658	42202-42205	FW	denotes	al.
T8659	42206-42210	CD	denotes	2002
T8660	42210-42211	:	denotes	;
T8661	42212-42216	NNP	denotes	Bush
T8662	42217-42219	FW	denotes	et
T8663	42220-42223	FW	denotes	al.
T8664	42224-42228	CD	denotes	2002
T8665	42228-42229	:	denotes	;
T8666	42230-42234	NNP	denotes	Herr
T8667	42235-42237	FW	denotes	et
T8668	42238-42241	FW	denotes	al.
T8669	42242-42246	CD	denotes	2003
T8670	42246-42247	-RRB-	denotes	)
T8671	42247-42248	.	denotes	.
T8672	42248-42540	sentence	denotes	These observations suggest that an ancestral gene for Tbx15, Tbx18, and Tbx22 may have been important for craniofacial development in cephalochordates, with acquisition of additional expression patterns and developmental functions in the limb and the trunk during early vertebrate evolution.
T8673	42249-42254	DT	denotes	These
T8674	42255-42267	NNS	denotes	observations
T8675	42268-42275	VBP	denotes	suggest
T8676	42276-42280	IN	denotes	that
T8677	42336-42340	VBN	denotes	been
T8678	42281-42283	DT	denotes	an
T8679	42294-42298	NN	denotes	gene
T8680	42284-42293	JJ	denotes	ancestral
T8681	42299-42302	IN	denotes	for
T8682	42303-42308	NN	denotes	Tbx15
T8683	42308-42310	,	denotes	,
T8684	42310-42315	NN	denotes	Tbx18
T8685	42315-42317	,	denotes	,
T8686	42317-42320	CC	denotes	and
T8687	42321-42326	NN	denotes	Tbx22
T8688	42327-42330	MD	denotes	may
T8689	42331-42335	VB	denotes	have
T8690	42341-42350	JJ	denotes	important
T8691	42351-42354	IN	denotes	for
T8692	42355-42367	JJ	denotes	craniofacial
T8693	42368-42379	NN	denotes	development
T8694	42380-42382	IN	denotes	in
T8695	42383-42399	NNS	denotes	cephalochordates
T8696	42399-42401	,	denotes	,
T8697	42401-42405	IN	denotes	with
T8698	42406-42417	NN	denotes	acquisition
T8699	42418-42420	IN	denotes	of
T8700	42421-42431	JJ	denotes	additional
T8701	42443-42451	NNS	denotes	patterns
T8702	42432-42442	NN	denotes	expression
T8703	42452-42455	CC	denotes	and
T8704	42456-42469	JJ	denotes	developmental
T8705	42470-42479	NNS	denotes	functions
T8706	42480-42482	IN	denotes	in
T8707	42483-42486	DT	denotes	the
T8708	42487-42491	NN	denotes	limb
T8709	42492-42495	CC	denotes	and
T8710	42496-42499	DT	denotes	the
T8711	42500-42505	NN	denotes	trunk
T8712	42506-42512	IN	denotes	during
T8713	42513-42518	JJ	denotes	early
T8714	42530-42539	NN	denotes	evolution
T8715	42519-42529	NN	denotes	vertebrate
T8716	42539-42540	.	denotes	.
T8717	42540-42740	sentence	denotes	Expression of Tbx18 and Tbx22 has not been reported in embryonic flank mesenchyme, which suggests that Tbx15 is the only family member involved in establishing the dorsoventral identity of the trunk.
T8718	42541-42551	NN	denotes	Expression
T8719	42584-42592	VBN	denotes	reported
T8720	42552-42554	IN	denotes	of
T8721	42555-42560	NN	denotes	Tbx18
T8722	42561-42564	CC	denotes	and
T8723	42565-42570	NN	denotes	Tbx22
T8724	42571-42574	VBZ	denotes	has
T8725	42575-42578	RB	denotes	not
T8726	42579-42583	VBN	denotes	been
T8727	42593-42595	IN	denotes	in
T8728	42596-42605	JJ	denotes	embryonic
T8729	42612-42622	NN	denotes	mesenchyme
T8730	42606-42611	NN	denotes	flank
T8731	42622-42624	,	denotes	,
T8732	42624-42629	WDT	denotes	which
T8733	42630-42638	VBZ	denotes	suggests
T8734	42639-42643	IN	denotes	that
T8735	42650-42652	VBZ	denotes	is
T8736	42644-42649	NN	denotes	Tbx15
T8737	42653-42656	DT	denotes	the
T8738	42669-42675	NN	denotes	member
T8739	42657-42661	JJ	denotes	only
T8740	42662-42668	NN	denotes	family
T8741	42676-42684	VBN	denotes	involved
T8742	42685-42687	IN	denotes	in
T8743	42688-42700	VBG	denotes	establishing
T8744	42701-42704	DT	denotes	the
T8745	42718-42726	NN	denotes	identity
T8746	42705-42717	JJ	denotes	dorsoventral
T8747	42727-42729	IN	denotes	of
T8748	42730-42733	DT	denotes	the
T8749	42734-42739	NN	denotes	trunk
T8750	42739-42740	.	denotes	.
T8751	42740-42942	sentence	denotes	However, it would not be surprising to find some degree of functional redundancy in animals mutated for two or three of the subfamily members in other body regions, particularly the limbs and the head.
T8752	42741-42748	RB	denotes	However
T8753	42763-42765	VB	denotes	be
T8754	42748-42750	,	denotes	,
T8755	42750-42752	PRP	denotes	it
T8756	42753-42758	MD	denotes	would
T8757	42759-42762	RB	denotes	not
T8758	42766-42776	JJ	denotes	surprising
T8759	42777-42779	TO	denotes	to
T8760	42780-42784	VB	denotes	find
T8761	42785-42789	DT	denotes	some
T8762	42790-42796	NN	denotes	degree
T8763	42797-42799	IN	denotes	of
T8764	42800-42810	JJ	denotes	functional
T8765	42811-42821	NN	denotes	redundancy
T8766	42822-42824	IN	denotes	in
T8767	42825-42832	NNS	denotes	animals
T8768	42833-42840	VBN	denotes	mutated
T8769	42841-42844	IN	denotes	for
T8770	42845-42848	CD	denotes	two
T8771	42849-42851	CC	denotes	or
T8772	42852-42857	CD	denotes	three
T8773	42858-42860	IN	denotes	of
T8774	42861-42864	DT	denotes	the
T8775	42875-42882	NNS	denotes	members
T8776	42865-42874	NN	denotes	subfamily
T8777	42883-42885	IN	denotes	in
T8778	42886-42891	JJ	denotes	other
T8779	42897-42904	NNS	denotes	regions
T8780	42892-42896	NN	denotes	body
T8781	42904-42906	,	denotes	,
T8782	42906-42918	RB	denotes	particularly
T8783	42923-42928	NNS	denotes	limbs
T8784	42919-42922	DT	denotes	the
T8785	42929-42932	CC	denotes	and
T8786	42933-42936	DT	denotes	the
T8787	42937-42941	NN	denotes	head
T8788	42941-42942	.	denotes	.
T8789	42942-43064	sentence	denotes	For example, mutations in Tbx22 cause the human syndrome X-linked cleft palate and ankyloglossia (Braybrook et al. 2001).
T8790	42943-42946	IN	denotes	For
T8791	42975-42980	VBP	denotes	cause
T8792	42947-42954	NN	denotes	example
T8793	42954-42956	,	denotes	,
T8794	42956-42965	NNS	denotes	mutations
T8795	42966-42968	IN	denotes	in
T8796	42969-42974	NN	denotes	Tbx22
T8797	42981-42984	DT	denotes	the
T8798	42991-42999	NN	denotes	syndrome
T8799	42985-42990	JJ	denotes	human
T8800	43000-43001	NN	denotes	X
T8801	43002-43008	VBN	denotes	linked
T8802	43001-43002	HYPH	denotes	-
T8803	43015-43021	NN	denotes	palate
T8804	43009-43014	JJ	denotes	cleft
T8805	43022-43025	CC	denotes	and
T8806	43026-43039	NN	denotes	ankyloglossia
T8807	43040-43041	-LRB-	denotes	(
T8808	43041-43050	NNP	denotes	Braybrook
T8809	43051-43053	FW	denotes	et
T8810	43054-43057	FW	denotes	al.
T8811	43058-43062	CD	denotes	2001
T8812	43062-43063	-RRB-	denotes	)
T8813	43063-43064	.	denotes	.
T8814	43064-43314	sentence	denotes	Despite high levels of Tbx22 expression in periocular embryonic mesenchyme (Braybrook et al. 2002; Bush et al. 2002; Herr et al. 2003), the condition does not affect the eye, perhaps because residual activity is provided by Tbx15 in the same region.
T8815	43065-43072	IN	denotes	Despite
T8816	43224-43230	VB	denotes	affect
T8817	43073-43077	JJ	denotes	high
T8818	43078-43084	NNS	denotes	levels
T8819	43085-43087	IN	denotes	of
T8820	43088-43093	NN	denotes	Tbx22
T8821	43094-43104	NN	denotes	expression
T8822	43105-43107	IN	denotes	in
T8823	43108-43118	JJ	denotes	periocular
T8824	43129-43139	NN	denotes	mesenchyme
T8825	43119-43128	JJ	denotes	embryonic
T8826	43140-43141	-LRB-	denotes	(
T8827	43141-43150	NNP	denotes	Braybrook
T8828	43151-43153	FW	denotes	et
T8829	43154-43157	FW	denotes	al.
T8830	43158-43162	CD	denotes	2002
T8831	43162-43163	:	denotes	;
T8832	43164-43168	NNP	denotes	Bush
T8833	43169-43171	FW	denotes	et
T8834	43172-43175	FW	denotes	al.
T8835	43176-43180	CD	denotes	2002
T8836	43180-43181	:	denotes	;
T8837	43182-43186	NNP	denotes	Herr
T8838	43187-43189	FW	denotes	et
T8839	43190-43193	FW	denotes	al.
T8840	43194-43198	CD	denotes	2003
T8841	43198-43199	-RRB-	denotes	)
T8842	43199-43201	,	denotes	,
T8843	43201-43204	DT	denotes	the
T8844	43205-43214	NN	denotes	condition
T8845	43215-43219	VBZ	denotes	does
T8846	43220-43223	RB	denotes	not
T8847	43231-43234	DT	denotes	the
T8848	43235-43238	NN	denotes	eye
T8849	43238-43240	,	denotes	,
T8850	43240-43247	RB	denotes	perhaps
T8851	43277-43285	VBN	denotes	provided
T8852	43248-43255	IN	denotes	because
T8853	43256-43264	JJ	denotes	residual
T8854	43265-43273	NN	denotes	activity
T8855	43274-43276	VBZ	denotes	is
T8856	43286-43288	IN	denotes	by
T8857	43289-43294	NN	denotes	Tbx15
T8858	43295-43297	IN	denotes	in
T8859	43298-43301	DT	denotes	the
T8860	43307-43313	NN	denotes	region
T8861	43302-43306	JJ	denotes	same
T8862	43313-43314	.	denotes	.
T8863	43314-43616	sentence	denotes	In an initial description of the expression and map location of mouse Tbx15, Agulnik et al. (1998) suggested human Tbx15 that lies on Chromosome 1p11.1 as a candidate for acromegaloid facial appearance (AFA) syndrome, for which there is a weak positive LOD score to Chromosome 1p (Hughes et al. 1985).
T8864	43315-43317	IN	denotes	In
T8865	43414-43423	VBD	denotes	suggested
T8866	43318-43320	DT	denotes	an
T8867	43329-43340	NN	denotes	description
T8868	43321-43328	JJ	denotes	initial
T8869	43341-43343	IN	denotes	of
T8870	43344-43347	DT	denotes	the
T8871	43348-43358	NN	denotes	expression
T8872	43359-43362	CC	denotes	and
T8873	43363-43366	NN	denotes	map
T8874	43367-43375	NN	denotes	location
T8875	43376-43378	IN	denotes	of
T8876	43379-43384	NN	denotes	mouse
T8877	43385-43390	NN	denotes	Tbx15
T8878	43390-43392	,	denotes	,
T8879	43392-43399	NNP	denotes	Agulnik
T8880	43400-43402	FW	denotes	et
T8881	43403-43406	FW	denotes	al.
T8882	43407-43408	-LRB-	denotes	(
T8883	43408-43412	CD	denotes	1998
T8884	43412-43413	-RRB-	denotes	)
T8885	43424-43429	JJ	denotes	human
T8886	43430-43435	NN	denotes	Tbx15
T8887	43436-43440	WDT	denotes	that
T8888	43441-43445	VBZ	denotes	lies
T8889	43446-43448	IN	denotes	on
T8890	43449-43459	NN	denotes	Chromosome
T8891	43460-43466	NN	denotes	1p11.1
T8892	43467-43469	IN	denotes	as
T8893	43470-43471	DT	denotes	a
T8894	43472-43481	NN	denotes	candidate
T8895	43482-43485	IN	denotes	for
T8896	43486-43498	JJ	denotes	acromegaloid
T8897	43506-43516	NN	denotes	appearance
T8898	43499-43505	JJ	denotes	facial
T8899	43523-43531	NN	denotes	syndrome
T8900	43517-43518	-LRB-	denotes	(
T8901	43518-43521	NN	denotes	AFA
T8902	43521-43522	-RRB-	denotes	)
T8903	43531-43533	,	denotes	,
T8904	43533-43536	IN	denotes	for
T8905	43549-43551	VBZ	denotes	is
T8906	43537-43542	WDT	denotes	which
T8907	43543-43548	EX	denotes	there
T8908	43552-43553	DT	denotes	a
T8909	43572-43577	NN	denotes	score
T8910	43554-43558	JJ	denotes	weak
T8911	43559-43567	JJ	denotes	positive
T8912	43568-43571	NN	denotes	LOD
T8913	43578-43580	IN	denotes	to
T8914	43581-43591	NN	denotes	Chromosome
T8915	43592-43594	NN	denotes	1p
T8916	43595-43596	-LRB-	denotes	(
T8917	43596-43602	NNP	denotes	Hughes
T8918	43603-43605	FW	denotes	et
T8919	43606-43609	FW	denotes	al.
T8920	43610-43614	CD	denotes	1985
T8921	43614-43615	-RRB-	denotes	)
T8922	43615-43616	.	denotes	.
T8923	43616-43990	sentence	denotes	Originally described as a rare autosomal-dominant syndrome with progressive facial coarsening, overgrowth of the intraoral mucosa, and large, doughy hands, more recent case reports describe macrosomia, macrocephaly, or both and generalized hypertrichosis with progressive coarsening (Dallapiccola et al. 1992; Irvine et al. 1996; da Silva et al. 1998; Zelante et al. 2000).
T8924	43617-43627	RB	denotes	Originally
T8925	43628-43637	VBN	denotes	described
T8926	43798-43806	VBP	denotes	describe
T8927	43638-43640	IN	denotes	as
T8928	43641-43642	DT	denotes	a
T8929	43667-43675	NN	denotes	syndrome
T8930	43643-43647	JJ	denotes	rare
T8931	43648-43657	JJ	denotes	autosomal
T8932	43658-43666	JJ	denotes	dominant
T8933	43657-43658	HYPH	denotes	-
T8934	43676-43680	IN	denotes	with
T8935	43681-43692	JJ	denotes	progressive
T8936	43700-43710	NN	denotes	coarsening
T8937	43693-43699	JJ	denotes	facial
T8938	43710-43712	,	denotes	,
T8939	43712-43722	NN	denotes	overgrowth
T8940	43723-43725	IN	denotes	of
T8941	43726-43729	DT	denotes	the
T8942	43740-43746	NN	denotes	mucosa
T8943	43730-43739	JJ	denotes	intraoral
T8944	43746-43748	,	denotes	,
T8945	43748-43751	CC	denotes	and
T8946	43752-43757	JJ	denotes	large
T8947	43766-43771	NNS	denotes	hands
T8948	43757-43759	,	denotes	,
T8949	43759-43765	JJ	denotes	doughy
T8950	43771-43773	,	denotes	,
T8951	43773-43777	RBR	denotes	more
T8952	43778-43784	JJ	denotes	recent
T8953	43790-43797	NNS	denotes	reports
T8954	43785-43789	NN	denotes	case
T8955	43807-43817	NN	denotes	macrosomia
T8956	43817-43819	,	denotes	,
T8957	43819-43831	NN	denotes	macrocephaly
T8958	43831-43833	,	denotes	,
T8959	43833-43835	CC	denotes	or
T8960	43836-43840	DT	denotes	both
T8961	43841-43844	CC	denotes	and
T8962	43845-43856	VBN	denotes	generalized
T8963	43857-43871	NN	denotes	hypertrichosis
T8964	43872-43876	IN	denotes	with
T8965	43877-43888	JJ	denotes	progressive
T8966	43889-43899	NN	denotes	coarsening
T8967	43900-43901	-LRB-	denotes	(
T8968	43901-43913	NNP	denotes	Dallapiccola
T8969	43914-43916	FW	denotes	et
T8970	43917-43920	FW	denotes	al.
T8971	43921-43925	CD	denotes	1992
T8972	43925-43926	:	denotes	;
T8973	43927-43933	NNP	denotes	Irvine
T8974	43934-43936	FW	denotes	et
T8975	43937-43940	FW	denotes	al.
T8976	43941-43945	CD	denotes	1996
T8977	43945-43946	:	denotes	;
T8978	43947-43949	NNP	denotes	da
T8979	43950-43955	NNP	denotes	Silva
T8980	43956-43958	FW	denotes	et
T8981	43959-43962	FW	denotes	al.
T8982	43963-43967	CD	denotes	1998
T8983	43967-43968	:	denotes	;
T8984	43969-43976	NNP	denotes	Zelante
T8985	43977-43979	FW	denotes	et
T8986	43980-43983	FW	denotes	al.
T8987	43984-43988	CD	denotes	2000
T8988	43988-43989	-RRB-	denotes	)
T8989	43989-43990	.	denotes	.
T8990	43990-44300	sentence	denotes	The deH phenotype exhibits little overlap with these features; instead, we suggest a more likely candidate for mutations of human TBX15 would be frontofacionasal syndrome, an unmapped autosomal recessive condition characterized by brachycephaly, blepharophimosis, and midface hypoplasia (Reardon et al. 1994).
T8991	43991-43994	DT	denotes	The
T8992	43999-44008	NN	denotes	phenotype
T8993	43995-43998	NN	denotes	deH
T8994	44009-44017	VBZ	denotes	exhibits
T8995	44066-44073	VBP	denotes	suggest
T8996	44018-44024	JJ	denotes	little
T8997	44025-44032	NN	denotes	overlap
T8998	44033-44037	IN	denotes	with
T8999	44038-44043	DT	denotes	these
T9000	44044-44052	NNS	denotes	features
T9001	44052-44053	:	denotes	;
T9002	44054-44061	RB	denotes	instead
T9003	44061-44063	,	denotes	,
T9004	44063-44065	PRP	denotes	we
T9005	44074-44075	DT	denotes	a
T9006	44088-44097	NN	denotes	candidate
T9007	44076-44080	RBR	denotes	more
T9008	44081-44087	JJ	denotes	likely
T9009	44133-44135	VB	denotes	be
T9010	44098-44101	IN	denotes	for
T9011	44102-44111	NNS	denotes	mutations
T9012	44112-44114	IN	denotes	of
T9013	44115-44120	JJ	denotes	human
T9014	44121-44126	NN	denotes	TBX15
T9015	44127-44132	MD	denotes	would
T9016	44136-44152	JJ	denotes	frontofacionasal
T9017	44153-44161	NN	denotes	syndrome
T9018	44161-44163	,	denotes	,
T9019	44163-44165	DT	denotes	an
T9020	44195-44204	NN	denotes	condition
T9021	44166-44174	JJ	denotes	unmapped
T9022	44175-44184	JJ	denotes	autosomal
T9023	44185-44194	JJ	denotes	recessive
T9024	44205-44218	VBN	denotes	characterized
T9025	44219-44221	IN	denotes	by
T9026	44222-44235	RB	denotes	brachycephaly
T9027	44235-44237	,	denotes	,
T9028	44237-44253	NN	denotes	blepharophimosis
T9029	44253-44255	,	denotes	,
T9030	44255-44258	CC	denotes	and
T9031	44259-44266	JJ	denotes	midface
T9032	44267-44277	NN	denotes	hypoplasia
T9033	44278-44279	-LRB-	denotes	(
T9034	44279-44286	NNP	denotes	Reardon
T9035	44287-44289	FW	denotes	et
T9036	44290-44293	FW	denotes	al.
T9037	44294-44298	CD	denotes	1994
T9038	44298-44299	-RRB-	denotes	)
T9039	44299-44300	.	denotes	.
T9040	44300-44553	sentence	denotes	Two of us (S. Kuijper and F. Meijlink) became interested in the deH mutation because of its effects on skeletal development (Curry 1959) and the possibility that the aristaless-related gene Alx3 might be allelic with droopy ear (ten Berge et al. 1998).
T9041	44301-44304	CD	denotes	Two
T9042	44340-44346	VBD	denotes	became
T9043	44305-44307	IN	denotes	of
T9044	44308-44310	PRP	denotes	us
T9045	44311-44312	-LRB-	denotes	(
T9046	44312-44314	NNP	denotes	S.
T9047	44315-44322	NNP	denotes	Kuijper
T9048	44323-44326	CC	denotes	and
T9049	44327-44329	NNP	denotes	F.
T9050	44330-44338	NNP	denotes	Meijlink
T9051	44338-44339	-RRB-	denotes	)
T9052	44347-44357	JJ	denotes	interested
T9053	44358-44360	IN	denotes	in
T9054	44361-44364	DT	denotes	the
T9055	44369-44377	NN	denotes	mutation
T9056	44365-44368	NN	denotes	deH
T9057	44378-44385	IN	denotes	because
T9058	44386-44388	IN	denotes	of
T9059	44389-44392	PRP$	denotes	its
T9060	44393-44400	NNS	denotes	effects
T9061	44401-44403	IN	denotes	on
T9062	44404-44412	JJ	denotes	skeletal
T9063	44413-44424	NN	denotes	development
T9064	44425-44426	-LRB-	denotes	(
T9065	44426-44431	NNP	denotes	Curry
T9066	44432-44436	CD	denotes	1959
T9067	44436-44437	-RRB-	denotes	)
T9068	44438-44441	CC	denotes	and
T9069	44442-44445	DT	denotes	the
T9070	44446-44457	NN	denotes	possibility
T9071	44458-44462	IN	denotes	that
T9072	44502-44504	VB	denotes	be
T9073	44463-44466	DT	denotes	the
T9074	44486-44490	NN	denotes	gene
T9075	44467-44477	NN	denotes	aristaless
T9076	44478-44485	VBN	denotes	related
T9077	44477-44478	HYPH	denotes	-
T9078	44491-44495	NN	denotes	Alx3
T9079	44496-44501	MD	denotes	might
T9080	44505-44512	JJ	denotes	allelic
T9081	44513-44517	IN	denotes	with
T9082	44518-44524	JJ	denotes	droopy
T9083	44525-44528	NN	denotes	ear
T9084	44529-44530	-LRB-	denotes	(
T9085	44530-44533	NNP	denotes	ten
T9086	44534-44539	NNP	denotes	Berge
T9087	44540-44542	FW	denotes	et
T9088	44543-44546	FW	denotes	al.
T9089	44547-44551	CD	denotes	1998
T9090	44551-44552	-RRB-	denotes	)
T9091	44552-44553	.	denotes	.
T9092	44553-44800	sentence	denotes	In spite of similarities between skeletal phenotypes of deH and Alx3 or Alx4 mutants, subsequent experiments (unpublished data) excluded allelism of Alx3 and deH, and a full description of the Tbx15 skeletal phenotype will be published elsewhere.
T9093	44554-44556	IN	denotes	In
T9094	44682-44690	VBD	denotes	excluded
T9095	44557-44562	NN	denotes	spite
T9096	44563-44565	IN	denotes	of
T9097	44566-44578	NNS	denotes	similarities
T9098	44579-44586	IN	denotes	between
T9099	44587-44595	JJ	denotes	skeletal
T9100	44596-44606	NNS	denotes	phenotypes
T9101	44607-44609	IN	denotes	of
T9102	44610-44613	NN	denotes	deH
T9103	44631-44638	NNS	denotes	mutants
T9104	44614-44617	CC	denotes	and
T9105	44618-44622	NN	denotes	Alx3
T9106	44623-44625	CC	denotes	or
T9107	44626-44630	NN	denotes	Alx4
T9108	44638-44640	,	denotes	,
T9109	44640-44650	JJ	denotes	subsequent
T9110	44651-44662	NNS	denotes	experiments
T9111	44663-44664	-LRB-	denotes	(
T9112	44676-44680	NNS	denotes	data
T9113	44664-44675	JJ	denotes	unpublished
T9114	44680-44681	-RRB-	denotes	)
T9115	44691-44699	NN	denotes	allelism
T9116	44700-44702	IN	denotes	of
T9117	44703-44707	NN	denotes	Alx3
T9118	44708-44711	CC	denotes	and
T9119	44712-44715	NN	denotes	deH
T9120	44715-44717	,	denotes	,
T9121	44717-44720	CC	denotes	and
T9122	44721-44722	DT	denotes	a
T9123	44728-44739	NN	denotes	description
T9124	44723-44727	JJ	denotes	full
T9125	44780-44789	VBN	denotes	published
T9126	44740-44742	IN	denotes	of
T9127	44743-44746	DT	denotes	the
T9128	44762-44771	NN	denotes	phenotype
T9129	44747-44752	NN	denotes	Tbx15
T9130	44753-44761	JJ	denotes	skeletal
T9131	44772-44776	MD	denotes	will
T9132	44777-44779	VB	denotes	be
T9133	44790-44799	RB	denotes	elsewhere
T9134	44799-44800	.	denotes	.
T9366	44802-44815	JJ	denotes	Developmental
T9367	44816-44825	NN	denotes	Mechanism
T9368	44826-44828	IN	denotes	of
T9369	44829-44834	NN	denotes	Tbx15
T9370	44835-44845	NN	denotes	Expression
T9371	44846-44849	CC	denotes	and
T9372	44850-44856	NN	denotes	Action
T9373	44857-44859	IN	denotes	in
T9374	44860-44863	DT	denotes	the
T9375	44864-44868	NN	denotes	Skin
T9376	44868-44986	sentence	denotes	Our attention to the role of Tbx15 in pigment patterning was motivated by the effects of Agouti in postnatal animals.
T9377	44869-44872	PRP$	denotes	Our
T9378	44873-44882	NN	denotes	attention
T9379	44930-44939	VBN	denotes	motivated
T9380	44883-44885	IN	denotes	to
T9381	44886-44889	DT	denotes	the
T9382	44890-44894	NN	denotes	role
T9383	44895-44897	IN	denotes	of
T9384	44898-44903	NN	denotes	Tbx15
T9385	44904-44906	IN	denotes	in
T9386	44907-44914	NN	denotes	pigment
T9387	44915-44925	NN	denotes	patterning
T9388	44926-44929	VBD	denotes	was
T9389	44940-44942	IN	denotes	by
T9390	44943-44946	DT	denotes	the
T9391	44947-44954	NNS	denotes	effects
T9392	44955-44957	IN	denotes	of
T9393	44958-44964	NN	denotes	Agouti
T9394	44965-44967	IN	denotes	in
T9395	44968-44977	JJ	denotes	postnatal
T9396	44978-44985	NNS	denotes	animals
T9397	44985-44986	.	denotes	.
T9398	44986-45101	sentence	denotes	However, Agouti is also expressed in the embryo, where it provides a convenient marker of ventral dermis identity.
T9399	44987-44994	RB	denotes	However
T9400	45011-45020	VBN	denotes	expressed
T9401	44994-44996	,	denotes	,
T9402	44996-45002	NN	denotes	Agouti
T9403	45003-45005	VBZ	denotes	is
T9404	45006-45010	RB	denotes	also
T9405	45021-45023	IN	denotes	in
T9406	45024-45027	DT	denotes	the
T9407	45028-45034	NN	denotes	embryo
T9408	45034-45036	,	denotes	,
T9409	45036-45041	WRB	denotes	where
T9410	45045-45053	VBZ	denotes	provides
T9411	45042-45044	PRP	denotes	it
T9412	45054-45055	DT	denotes	a
T9413	45067-45073	NN	denotes	marker
T9414	45056-45066	JJ	denotes	convenient
T9415	45074-45076	IN	denotes	of
T9416	45077-45084	JJ	denotes	ventral
T9417	45092-45100	NN	denotes	identity
T9418	45085-45091	NN	denotes	dermis
T9419	45100-45101	.	denotes	.
T9420	45101-45281	sentence	denotes	Because an expanded domain of embryonic Agouti expression in deH/deH animals is detectable by E14.5, the effects of Tbx15 on dorsoventral patterning must occur prior to this time.
T9421	45102-45109	IN	denotes	Because
T9422	45179-45181	VBZ	denotes	is
T9423	45110-45112	DT	denotes	an
T9424	45122-45128	NN	denotes	domain
T9425	45113-45121	VBN	denotes	expanded
T9426	45129-45131	IN	denotes	of
T9427	45132-45141	JJ	denotes	embryonic
T9428	45149-45159	NN	denotes	expression
T9429	45142-45148	NN	denotes	Agouti
T9430	45160-45162	IN	denotes	in
T9431	45163-45166	NN	denotes	deH
T9432	45167-45170	NN	denotes	deH
T9433	45166-45167	HYPH	denotes	/
T9434	45171-45178	NNS	denotes	animals
T9435	45256-45261	VB	denotes	occur
T9436	45182-45192	JJ	denotes	detectable
T9437	45193-45195	IN	denotes	by
T9438	45196-45201	NN	denotes	E14.5
T9439	45201-45203	,	denotes	,
T9440	45203-45206	DT	denotes	the
T9441	45207-45214	NNS	denotes	effects
T9442	45215-45217	IN	denotes	of
T9443	45218-45223	NN	denotes	Tbx15
T9444	45224-45226	IN	denotes	on
T9445	45227-45239	JJ	denotes	dorsoventral
T9446	45240-45250	NN	denotes	patterning
T9447	45251-45255	MD	denotes	must
T9448	45262-45267	RB	denotes	prior
T9449	45268-45270	IN	denotes	to
T9450	45271-45275	DT	denotes	this
T9451	45276-45280	NN	denotes	time
T9452	45280-45281	.	denotes	.
T9453	45281-45665	sentence	denotes	Among other T-box genes whose developmental actions are at least partially understood, two general themes have emerged, one focused on the ability to specify alternative fates for an undifferentiated group of precursor cells and another focused on the ability to support proliferative expansion of a cell population whose fate is already determined (reviewed in Tada and Smith 2001).
T9454	45282-45287	IN	denotes	Among
T9455	45393-45400	VBN	denotes	emerged
T9456	45288-45293	JJ	denotes	other
T9457	45300-45305	NNS	denotes	genes
T9458	45294-45295	NN	denotes	T
T9459	45296-45299	NN	denotes	box
T9460	45295-45296	HYPH	denotes	-
T9461	45306-45311	WP$	denotes	whose
T9462	45326-45333	NNS	denotes	actions
T9463	45312-45325	JJ	denotes	developmental
T9464	45357-45367	VBN	denotes	understood
T9465	45334-45337	VBP	denotes	are
T9466	45338-45340	RB	denotes	at
T9467	45341-45346	RBS	denotes	least
T9468	45347-45356	RB	denotes	partially
T9469	45367-45369	,	denotes	,
T9470	45369-45372	CD	denotes	two
T9471	45381-45387	NNS	denotes	themes
T9472	45373-45380	JJ	denotes	general
T9473	45388-45392	VBP	denotes	have
T9474	45400-45402	,	denotes	,
T9475	45402-45405	CD	denotes	one
T9476	45406-45413	VBD	denotes	focused
T9477	45414-45416	IN	denotes	on
T9478	45417-45420	DT	denotes	the
T9479	45421-45428	NN	denotes	ability
T9480	45429-45431	TO	denotes	to
T9481	45432-45439	VB	denotes	specify
T9482	45440-45451	JJ	denotes	alternative
T9483	45452-45457	NNS	denotes	fates
T9484	45458-45461	IN	denotes	for
T9485	45462-45464	DT	denotes	an
T9486	45482-45487	NN	denotes	group
T9487	45465-45481	JJ	denotes	undifferentiated
T9488	45488-45490	IN	denotes	of
T9489	45491-45500	NN	denotes	precursor
T9490	45501-45506	NNS	denotes	cells
T9491	45507-45510	CC	denotes	and
T9492	45511-45518	DT	denotes	another
T9493	45519-45526	VBD	denotes	focused
T9494	45527-45529	IN	denotes	on
T9495	45530-45533	DT	denotes	the
T9496	45534-45541	NN	denotes	ability
T9497	45542-45544	TO	denotes	to
T9498	45545-45552	VB	denotes	support
T9499	45553-45566	JJ	denotes	proliferative
T9500	45567-45576	NN	denotes	expansion
T9501	45577-45579	IN	denotes	of
T9502	45580-45581	DT	denotes	a
T9503	45587-45597	NN	denotes	population
T9504	45582-45586	NN	denotes	cell
T9505	45598-45603	WP$	denotes	whose
T9506	45604-45608	NN	denotes	fate
T9507	45620-45630	VBN	denotes	determined
T9508	45609-45611	VBZ	denotes	is
T9509	45612-45619	RB	denotes	already
T9510	45631-45632	-LRB-	denotes	(
T9511	45632-45640	VBN	denotes	reviewed
T9512	45641-45643	IN	denotes	in
T9513	45644-45648	NNP	denotes	Tada
T9514	45649-45652	CC	denotes	and
T9515	45653-45658	NNP	denotes	Smith
T9516	45659-45663	CD	denotes	2001
T9517	45663-45664	-RRB-	denotes	)
T9518	45664-45665	.	denotes	.
T9519	45665-45758	sentence	denotes	Either mechanism may apply to the apparent dorsal-to-ventral transformation in deH/deH mice.
T9520	45666-45672	DT	denotes	Either
T9521	45673-45682	NN	denotes	mechanism
T9522	45687-45692	VB	denotes	apply
T9523	45683-45686	MD	denotes	may
T9524	45693-45695	IN	denotes	to
T9525	45696-45699	DT	denotes	the
T9526	45727-45741	NN	denotes	transformation
T9527	45700-45708	JJ	denotes	apparent
T9528	45709-45715	JJ	denotes	dorsal
T9529	45715-45716	HYPH	denotes	-
T9530	45716-45718	IN	denotes	to
T9531	45718-45719	HYPH	denotes	-
T9532	45719-45726	JJ	denotes	ventral
T9533	45742-45744	IN	denotes	in
T9534	45745-45748	NN	denotes	deH
T9535	45749-45752	NN	denotes	deH
T9536	45748-45749	HYPH	denotes	/
T9537	45753-45757	NNS	denotes	mice
T9538	45757-45758	.	denotes	.
T9539	45758-46132	sentence	denotes	For example, while the expanded domain of Agouti expression in postnatal deH/deH animals can be traced to events that occur between E11.5 and E13.5, the underlying cause may be that embryonic cells in dorsolateral mesenchyme acquire a ventral rather than dorsal identity or that those cells fail to proliferate normally, followed by compensatory expansion of ventral cells.
T9540	45759-45762	IN	denotes	For
T9541	45933-45935	VB	denotes	be
T9542	45763-45770	NN	denotes	example
T9543	45770-45772	,	denotes	,
T9544	45772-45777	IN	denotes	while
T9545	45855-45861	VBN	denotes	traced
T9546	45778-45781	DT	denotes	the
T9547	45791-45797	NN	denotes	domain
T9548	45782-45790	VBN	denotes	expanded
T9549	45798-45800	IN	denotes	of
T9550	45801-45807	NN	denotes	Agouti
T9551	45808-45818	NN	denotes	expression
T9552	45819-45821	IN	denotes	in
T9553	45822-45831	JJ	denotes	postnatal
T9554	45840-45847	NNS	denotes	animals
T9555	45832-45835	NN	denotes	deH
T9556	45836-45839	NN	denotes	deH
T9557	45835-45836	HYPH	denotes	/
T9558	45848-45851	MD	denotes	can
T9559	45852-45854	VB	denotes	be
T9560	45862-45864	IN	denotes	to
T9561	45865-45871	NNS	denotes	events
T9562	45872-45876	WDT	denotes	that
T9563	45877-45882	VBP	denotes	occur
T9564	45883-45890	IN	denotes	between
T9565	45891-45896	NN	denotes	E11.5
T9566	45897-45900	CC	denotes	and
T9567	45901-45906	NN	denotes	E13.5
T9568	45906-45908	,	denotes	,
T9569	45908-45911	DT	denotes	the
T9570	45923-45928	NN	denotes	cause
T9571	45912-45922	JJ	denotes	underlying
T9572	45929-45932	MD	denotes	may
T9573	45936-45940	IN	denotes	that
T9574	45984-45991	VBP	denotes	acquire
T9575	45941-45950	JJ	denotes	embryonic
T9576	45951-45956	NNS	denotes	cells
T9577	45957-45959	IN	denotes	in
T9578	45960-45972	JJ	denotes	dorsolateral
T9579	45973-45983	NN	denotes	mesenchyme
T9580	45992-45993	DT	denotes	a
T9581	46021-46029	NN	denotes	identity
T9582	45994-46001	JJ	denotes	ventral
T9583	46002-46008	IN	denotes	rather
T9584	46009-46013	IN	denotes	than
T9585	46014-46020	JJ	denotes	dorsal
T9586	46030-46032	CC	denotes	or
T9587	46033-46037	IN	denotes	that
T9588	46050-46054	VBP	denotes	fail
T9589	46038-46043	DT	denotes	those
T9590	46044-46049	NNS	denotes	cells
T9591	46055-46057	TO	denotes	to
T9592	46058-46069	VB	denotes	proliferate
T9593	46070-46078	RB	denotes	normally
T9594	46078-46080	,	denotes	,
T9595	46080-46088	VBN	denotes	followed
T9596	46089-46091	IN	denotes	by
T9597	46092-46104	JJ	denotes	compensatory
T9598	46105-46114	NN	denotes	expansion
T9599	46115-46117	IN	denotes	of
T9600	46118-46125	JJ	denotes	ventral
T9601	46126-46131	NNS	denotes	cells
T9602	46131-46132	.	denotes	.
T9603	46132-46455	sentence	denotes	Cell lineage studies should provide a definitive answer, but we favor the latter hypothesis, because measurements of dorsoventral regions according to hair color in deH/deH mice revealed a small increase of the cream-colored ventral region in addition to the approximate doubling of the yellow flank region (see Figure 2).
T9604	46133-46137	NN	denotes	Cell
T9605	46138-46145	NN	denotes	lineage
T9606	46146-46153	NNS	denotes	studies
T9607	46161-46168	VB	denotes	provide
T9608	46154-46160	MD	denotes	should
T9609	46169-46170	DT	denotes	a
T9610	46182-46188	NN	denotes	answer
T9611	46171-46181	JJ	denotes	definitive
T9612	46188-46190	,	denotes	,
T9613	46190-46193	CC	denotes	but
T9614	46194-46196	PRP	denotes	we
T9615	46197-46202	VBP	denotes	favor
T9616	46203-46206	DT	denotes	the
T9617	46214-46224	NN	denotes	hypothesis
T9618	46207-46213	JJ	denotes	latter
T9619	46224-46226	,	denotes	,
T9620	46226-46233	IN	denotes	because
T9621	46311-46319	VBD	denotes	revealed
T9622	46234-46246	NNS	denotes	measurements
T9623	46247-46249	IN	denotes	of
T9624	46250-46262	JJ	denotes	dorsoventral
T9625	46263-46270	NNS	denotes	regions
T9626	46271-46280	VBG	denotes	according
T9627	46281-46283	IN	denotes	to
T9628	46284-46288	NN	denotes	hair
T9629	46289-46294	NN	denotes	color
T9630	46295-46297	IN	denotes	in
T9631	46298-46301	NN	denotes	deH
T9632	46302-46305	NN	denotes	deH
T9633	46301-46302	HYPH	denotes	/
T9634	46306-46310	NNS	denotes	mice
T9635	46320-46321	DT	denotes	a
T9636	46328-46336	NN	denotes	increase
T9637	46322-46327	JJ	denotes	small
T9638	46337-46339	IN	denotes	of
T9639	46340-46343	DT	denotes	the
T9640	46366-46372	NN	denotes	region
T9641	46344-46349	JJ	denotes	cream
T9642	46350-46357	JJ	denotes	colored
T9643	46349-46350	HYPH	denotes	-
T9644	46358-46365	JJ	denotes	ventral
T9645	46373-46375	IN	denotes	in
T9646	46376-46384	NN	denotes	addition
T9647	46385-46387	IN	denotes	to
T9648	46388-46391	DT	denotes	the
T9649	46404-46412	NN	denotes	doubling
T9650	46392-46403	JJ	denotes	approximate
T9651	46413-46415	IN	denotes	of
T9652	46416-46419	DT	denotes	the
T9653	46433-46439	NN	denotes	region
T9654	46420-46426	JJ	denotes	yellow
T9655	46427-46432	NN	denotes	flank
T9656	46440-46441	-LRB-	denotes	(
T9657	46441-46444	VB	denotes	see
T9658	46445-46451	NN	denotes	Figure
T9659	46452-46453	CD	denotes	2
T9660	46453-46454	-RRB-	denotes	)
T9661	46454-46455	.	denotes	.
T9662	46455-46634	sentence	denotes	In embryonic mesenchyme, expression of Tbx15 and Agouti are complementary, and it is possible that Tbx15 acts directly to inhibit Agouti transcription in dorsolateral mesenchyme.
T9663	46456-46458	IN	denotes	In
T9664	46512-46515	VBP	denotes	are
T9665	46459-46468	JJ	denotes	embryonic
T9666	46469-46479	NN	denotes	mesenchyme
T9667	46479-46481	,	denotes	,
T9668	46481-46491	NN	denotes	expression
T9669	46492-46494	IN	denotes	of
T9670	46495-46500	NN	denotes	Tbx15
T9671	46501-46504	CC	denotes	and
T9672	46505-46511	NN	denotes	Agouti
T9673	46516-46529	JJ	denotes	complementary
T9674	46529-46531	,	denotes	,
T9675	46531-46534	CC	denotes	and
T9676	46535-46537	PRP	denotes	it
T9677	46538-46540	VBZ	denotes	is
T9678	46541-46549	JJ	denotes	possible
T9679	46550-46554	IN	denotes	that
T9680	46561-46565	VBZ	denotes	acts
T9681	46555-46560	NN	denotes	Tbx15
T9682	46566-46574	RB	denotes	directly
T9683	46575-46577	TO	denotes	to
T9684	46578-46585	VB	denotes	inhibit
T9685	46586-46592	NN	denotes	Agouti
T9686	46593-46606	NN	denotes	transcription
T9687	46607-46609	IN	denotes	in
T9688	46610-46622	JJ	denotes	dorsolateral
T9689	46623-46633	NN	denotes	mesenchyme
T9690	46633-46634	.	denotes	.
T9691	46634-46895	sentence	denotes	However, the ability of Tbx15 to suppress expression of the ventral-specific Agouti isoform in postnatal mice is likely to be indirect, since postnatal expression of Tbx15 occurs broadly along the dorsoventral axis and overlaps extensively with that of Agouti.
T9692	46635-46642	RB	denotes	However
T9693	46745-46747	VBZ	denotes	is
T9694	46642-46644	,	denotes	,
T9695	46644-46647	DT	denotes	the
T9696	46648-46655	NN	denotes	ability
T9697	46656-46658	IN	denotes	of
T9698	46659-46664	NN	denotes	Tbx15
T9699	46665-46667	TO	denotes	to
T9700	46668-46676	VB	denotes	suppress
T9701	46677-46687	NN	denotes	expression
T9702	46688-46690	IN	denotes	of
T9703	46691-46694	DT	denotes	the
T9704	46719-46726	NN	denotes	isoform
T9705	46695-46702	JJ	denotes	ventral
T9706	46703-46711	JJ	denotes	specific
T9707	46702-46703	HYPH	denotes	-
T9708	46712-46718	NN	denotes	Agouti
T9709	46727-46729	IN	denotes	in
T9710	46730-46739	JJ	denotes	postnatal
T9711	46740-46744	NNS	denotes	mice
T9712	46748-46754	JJ	denotes	likely
T9713	46755-46757	TO	denotes	to
T9714	46758-46760	VB	denotes	be
T9715	46761-46769	JJ	denotes	indirect
T9716	46769-46771	,	denotes	,
T9717	46771-46776	IN	denotes	since
T9718	46807-46813	VBZ	denotes	occurs
T9719	46777-46786	JJ	denotes	postnatal
T9720	46787-46797	NN	denotes	expression
T9721	46798-46800	IN	denotes	of
T9722	46801-46806	NN	denotes	Tbx15
T9723	46814-46821	RB	denotes	broadly
T9724	46822-46827	IN	denotes	along
T9725	46828-46831	DT	denotes	the
T9726	46845-46849	NN	denotes	axis
T9727	46832-46844	JJ	denotes	dorsoventral
T9728	46850-46853	CC	denotes	and
T9729	46854-46862	VBZ	denotes	overlaps
T9730	46863-46874	RB	denotes	extensively
T9731	46875-46879	IN	denotes	with
T9732	46880-46884	DT	denotes	that
T9733	46885-46887	IN	denotes	of
T9734	46888-46894	NN	denotes	Agouti
T9735	46894-46895	.	denotes	.
T9736	46895-47128	sentence	denotes	In either case, the targets of Tbx15 action in the skin include genes in addition to Agouti, since hair length and melanocyte distribution exhibit a demonstrable, albeit subtle, alteration in animals that carry a null Agouti allele.
T9737	46896-46898	IN	denotes	In
T9738	46952-46959	VBP	denotes	include
T9739	46899-46905	DT	denotes	either
T9740	46906-46910	NN	denotes	case
T9741	46910-46912	,	denotes	,
T9742	46912-46915	DT	denotes	the
T9743	46916-46923	NNS	denotes	targets
T9744	46924-46926	IN	denotes	of
T9745	46927-46932	NN	denotes	Tbx15
T9746	46933-46939	NN	denotes	action
T9747	46940-46942	IN	denotes	in
T9748	46943-46946	DT	denotes	the
T9749	46947-46951	NN	denotes	skin
T9750	46960-46965	NNS	denotes	genes
T9751	46966-46968	IN	denotes	in
T9752	46969-46977	NN	denotes	addition
T9753	46978-46980	IN	denotes	to
T9754	46981-46987	NN	denotes	Agouti
T9755	46987-46989	,	denotes	,
T9756	46989-46994	IN	denotes	since
T9757	47035-47042	VBP	denotes	exhibit
T9758	46995-46999	NN	denotes	hair
T9759	47000-47006	NN	denotes	length
T9760	47007-47010	CC	denotes	and
T9761	47011-47021	NN	denotes	melanocyte
T9762	47022-47034	NN	denotes	distribution
T9763	47043-47044	DT	denotes	a
T9764	47074-47084	NN	denotes	alteration
T9765	47045-47057	JJ	denotes	demonstrable
T9766	47057-47059	,	denotes	,
T9767	47059-47065	CC	denotes	albeit
T9768	47066-47072	JJ	denotes	subtle
T9769	47072-47074	,	denotes	,
T9770	47085-47087	IN	denotes	in
T9771	47088-47095	NNS	denotes	animals
T9772	47096-47100	WDT	denotes	that
T9773	47101-47106	VBP	denotes	carry
T9774	47107-47108	DT	denotes	a
T9775	47121-47127	NN	denotes	allele
T9776	47109-47113	JJ	denotes	null
T9777	47114-47120	NN	denotes	Agouti
T9778	47127-47128	.	denotes	.
T9779	47128-47395	sentence	denotes	One potential target is Alx4, which, like Agouti, is expressed in ventral embryonic mesenchyme, and, when mutated, affects hair-follicle as well as limb and craniofacial development (Qu et al. 1997, 1998; Wu et al. 2000; Wuyts et al. 2000; Mavrogiannis et al. 2001).
T9780	47129-47132	CD	denotes	One
T9781	47143-47149	NN	denotes	target
T9782	47133-47142	JJ	denotes	potential
T9783	47150-47152	VBZ	denotes	is
T9784	47153-47157	NN	denotes	Alx4
T9785	47157-47159	,	denotes	,
T9786	47159-47164	WDT	denotes	which
T9787	47182-47191	VBN	denotes	expressed
T9788	47164-47166	,	denotes	,
T9789	47166-47170	IN	denotes	like
T9790	47171-47177	NN	denotes	Agouti
T9791	47177-47179	,	denotes	,
T9792	47179-47181	VBZ	denotes	is
T9793	47192-47194	IN	denotes	in
T9794	47195-47202	JJ	denotes	ventral
T9795	47213-47223	NN	denotes	mesenchyme
T9796	47203-47212	JJ	denotes	embryonic
T9797	47223-47225	,	denotes	,
T9798	47225-47228	CC	denotes	and
T9799	47228-47230	,	denotes	,
T9800	47230-47234	WRB	denotes	when
T9801	47235-47242	VBN	denotes	mutated
T9802	47244-47251	VBZ	denotes	affects
T9803	47242-47244	,	denotes	,
T9804	47252-47256	NN	denotes	hair
T9805	47257-47265	NN	denotes	follicle
T9806	47256-47257	HYPH	denotes	-
T9807	47299-47310	NN	denotes	development
T9808	47266-47268	RB	denotes	as
T9809	47274-47276	IN	denotes	as
T9810	47269-47273	RB	denotes	well
T9811	47277-47281	NN	denotes	limb
T9812	47282-47285	CC	denotes	and
T9813	47286-47298	JJ	denotes	craniofacial
T9814	47311-47312	-LRB-	denotes	(
T9815	47312-47314	NNP	denotes	Qu
T9816	47315-47317	FW	denotes	et
T9817	47318-47321	FW	denotes	al.
T9818	47322-47326	CD	denotes	1997
T9819	47326-47328	,	denotes	,
T9820	47328-47332	CD	denotes	1998
T9821	47332-47333	:	denotes	;
T9822	47334-47336	NNP	denotes	Wu
T9823	47337-47339	FW	denotes	et
T9824	47340-47343	FW	denotes	al.
T9825	47344-47348	CD	denotes	2000
T9826	47348-47349	:	denotes	;
T9827	47350-47355	NNP	denotes	Wuyts
T9828	47356-47358	FW	denotes	et
T9829	47359-47362	FW	denotes	al.
T9830	47363-47367	CD	denotes	2000
T9831	47367-47368	:	denotes	;
T9832	47369-47381	NNP	denotes	Mavrogiannis
T9833	47382-47384	FW	denotes	et
T9834	47385-47388	FW	denotes	al.
T9835	47389-47393	CD	denotes	2001
T9836	47393-47394	-RRB-	denotes	)
T9837	47394-47395	.	denotes	.
T9838	47395-47545	sentence	denotes	However, expression of ventral markers such as Alx4, as well as Alx3 and Msx2, appears to be unaffected at E11.5 in deH/deH embryos (data not shown).
T9839	47396-47403	RB	denotes	However
T9840	47475-47482	VBZ	denotes	appears
T9841	47403-47405	,	denotes	,
T9842	47405-47415	NN	denotes	expression
T9843	47416-47418	IN	denotes	of
T9844	47419-47426	JJ	denotes	ventral
T9845	47427-47434	NNS	denotes	markers
T9846	47435-47439	JJ	denotes	such
T9847	47440-47442	IN	denotes	as
T9848	47443-47447	NN	denotes	Alx4
T9849	47447-47449	,	denotes	,
T9850	47449-47451	RB	denotes	as
T9851	47457-47459	IN	denotes	as
T9852	47452-47456	RB	denotes	well
T9853	47460-47464	NN	denotes	Alx3
T9854	47465-47468	CC	denotes	and
T9855	47469-47473	NN	denotes	Msx2
T9856	47473-47475	,	denotes	,
T9857	47483-47485	TO	denotes	to
T9858	47486-47488	VB	denotes	be
T9859	47489-47499	JJ	denotes	unaffected
T9860	47500-47502	IN	denotes	at
T9861	47503-47508	NN	denotes	E11.5
T9862	47509-47511	IN	denotes	in
T9863	47512-47515	NN	denotes	deH
T9864	47516-47519	NN	denotes	deH
T9865	47515-47516	HYPH	denotes	/
T9866	47520-47527	NNS	denotes	embryos
T9867	47528-47529	-LRB-	denotes	(
T9868	47538-47543	VBN	denotes	shown
T9869	47529-47533	NNS	denotes	data
T9870	47534-47537	RB	denotes	not
T9871	47543-47544	-RRB-	denotes	)
T9872	47544-47545	.	denotes	.
T10219	47547-47558	NNS	denotes	Differences
T10220	47559-47562	CC	denotes	and
T10221	47563-47575	NNS	denotes	Similarities
T10222	47576-47578	IN	denotes	to
T10223	47579-47591	JJ	denotes	Dorsoventral
T10224	47597-47607	NN	denotes	Patterning
T10225	47592-47596	NN	denotes	Limb
T10226	47607-47770	sentence	denotes	Loss of Tbx15 also affects regional distribution of hair color in the limbs, with areas that would normally produce black hair giving rise to yellow hair instead.
T10227	47608-47612	NN	denotes	Loss
T10228	47627-47634	VBZ	denotes	affects
T10229	47613-47615	IN	denotes	of
T10230	47616-47621	NN	denotes	Tbx15
T10231	47622-47626	RB	denotes	also
T10232	47635-47643	JJ	denotes	regional
T10233	47644-47656	NN	denotes	distribution
T10234	47657-47659	IN	denotes	of
T10235	47660-47664	NN	denotes	hair
T10236	47665-47670	NN	denotes	color
T10237	47671-47673	IN	denotes	in
T10238	47674-47677	DT	denotes	the
T10239	47678-47683	NNS	denotes	limbs
T10240	47683-47685	,	denotes	,
T10241	47685-47689	IN	denotes	with
T10242	47690-47695	NNS	denotes	areas
T10243	47735-47741	VBG	denotes	giving
T10244	47696-47700	WDT	denotes	that
T10245	47716-47723	VB	denotes	produce
T10246	47701-47706	MD	denotes	would
T10247	47707-47715	RB	denotes	normally
T10248	47724-47729	JJ	denotes	black
T10249	47730-47734	NN	denotes	hair
T10250	47742-47746	NN	denotes	rise
T10251	47747-47749	IN	denotes	to
T10252	47750-47756	JJ	denotes	yellow
T10253	47757-47761	NN	denotes	hair
T10254	47762-47769	RB	denotes	instead
T10255	47769-47770	.	denotes	.
T10256	47770-47928	sentence	denotes	However, neither normal patterns of pigment-type synthesis in the limb nor their disruption in deH/deH mice correspond to obvious developmental compartments.
T10257	47771-47778	RB	denotes	However
T10258	47879-47889	VBP	denotes	correspond
T10259	47778-47780	,	denotes	,
T10260	47780-47787	CC	denotes	neither
T10261	47795-47803	NNS	denotes	patterns
T10262	47788-47794	JJ	denotes	normal
T10263	47804-47806	IN	denotes	of
T10264	47807-47814	JJ	denotes	pigment
T10265	47815-47819	NN	denotes	type
T10266	47814-47815	HYPH	denotes	-
T10267	47820-47829	NN	denotes	synthesis
T10268	47830-47832	IN	denotes	in
T10269	47833-47836	DT	denotes	the
T10270	47837-47841	NN	denotes	limb
T10271	47842-47845	CC	denotes	nor
T10272	47846-47851	PRP$	denotes	their
T10273	47852-47862	NN	denotes	disruption
T10274	47863-47865	IN	denotes	in
T10275	47866-47869	NN	denotes	deH
T10276	47870-47873	NN	denotes	deH
T10277	47869-47870	HYPH	denotes	/
T10278	47874-47878	NNS	denotes	mice
T10279	47890-47892	IN	denotes	to
T10280	47893-47900	JJ	denotes	obvious
T10281	47915-47927	NNS	denotes	compartments
T10282	47901-47914	JJ	denotes	developmental
T10283	47927-47928	.	denotes	.
T10284	47928-48262	sentence	denotes	Furthermore, losses of function for En1 or Wnt7a, which cause a partial transformation of the distal limb from dorsum to ventrum (Loomis et al. 1996) or ventrum to dorsum (Parr and McMahon 1995), respectively, have no effect on regional patterns of Agouti expression or distribution of hair-color regions (Y. Chen, unpublished data).
T10285	47929-47940	RB	denotes	Furthermore
T10286	48139-48143	VBP	denotes	have
T10287	47940-47942	,	denotes	,
T10288	47942-47948	NNS	denotes	losses
T10289	47949-47951	IN	denotes	of
T10290	47952-47960	NN	denotes	function
T10291	47961-47964	IN	denotes	for
T10292	47965-47968	NN	denotes	En1
T10293	47969-47971	CC	denotes	or
T10294	47972-47977	NN	denotes	Wnt7a
T10295	47977-47979	,	denotes	,
T10296	47979-47984	WDT	denotes	which
T10297	47985-47990	VBP	denotes	cause
T10298	47991-47992	DT	denotes	a
T10299	48001-48015	NN	denotes	transformation
T10300	47993-48000	JJ	denotes	partial
T10301	48016-48018	IN	denotes	of
T10302	48019-48022	DT	denotes	the
T10303	48030-48034	NN	denotes	limb
T10304	48023-48029	JJ	denotes	distal
T10305	48035-48039	IN	denotes	from
T10306	48040-48046	NN	denotes	dorsum
T10307	48047-48049	IN	denotes	to
T10308	48050-48057	NN	denotes	ventrum
T10309	48058-48059	-LRB-	denotes	(
T10310	48059-48065	NNP	denotes	Loomis
T10311	48066-48068	FW	denotes	et
T10312	48069-48072	FW	denotes	al.
T10313	48073-48077	CD	denotes	1996
T10314	48077-48078	-RRB-	denotes	)
T10315	48079-48081	CC	denotes	or
T10316	48082-48089	NN	denotes	ventrum
T10317	48090-48092	IN	denotes	to
T10318	48093-48099	NN	denotes	dorsum
T10319	48100-48101	-LRB-	denotes	(
T10320	48101-48105	NNP	denotes	Parr
T10321	48106-48109	CC	denotes	and
T10322	48110-48117	NNP	denotes	McMahon
T10323	48118-48122	CD	denotes	1995
T10324	48122-48123	-RRB-	denotes	)
T10325	48123-48125	,	denotes	,
T10326	48125-48137	RB	denotes	respectively
T10327	48137-48139	,	denotes	,
T10328	48144-48146	DT	denotes	no
T10329	48147-48153	NN	denotes	effect
T10330	48154-48156	IN	denotes	on
T10331	48157-48165	JJ	denotes	regional
T10332	48166-48174	NNS	denotes	patterns
T10333	48175-48177	IN	denotes	of
T10334	48178-48184	NN	denotes	Agouti
T10335	48185-48195	NN	denotes	expression
T10336	48196-48198	CC	denotes	or
T10337	48199-48211	NN	denotes	distribution
T10338	48212-48214	IN	denotes	of
T10339	48215-48219	NN	denotes	hair
T10340	48220-48225	NN	denotes	color
T10341	48219-48220	HYPH	denotes	-
T10342	48226-48233	NNS	denotes	regions
T10343	48234-48235	-LRB-	denotes	(
T10344	48235-48237	NNP	denotes	Y.
T10345	48238-48242	NNP	denotes	Chen
T10346	48242-48244	,	denotes	,
T10347	48244-48255	JJ	denotes	unpublished
T10348	48256-48260	NNS	denotes	data
T10349	48260-48261	-RRB-	denotes	)
T10350	48261-48262	.	denotes	.
T10351	48262-48581	sentence	denotes	(Ectopic pigmentation of the ventral footpads that develops in En1 mutant mice is unrelated to pigment-type synthesis and instead likely reflects a requirement for En1, independent of Wnt7a, to repress migration or proliferation (or both) of pigment cells in ventral epidermis [Cygan et al. 1997; Loomis et al. 1998].)
T10352	48263-48264	-LRB-	denotes	(
T10353	48342-48344	VBZ	denotes	is
T10354	48264-48271	JJ	denotes	Ectopic
T10355	48272-48284	NN	denotes	pigmentation
T10356	48285-48287	IN	denotes	of
T10357	48288-48291	DT	denotes	the
T10358	48300-48308	NNS	denotes	footpads
T10359	48292-48299	JJ	denotes	ventral
T10360	48309-48313	WDT	denotes	that
T10361	48314-48322	VBZ	denotes	develops
T10362	48323-48325	IN	denotes	in
T10363	48326-48329	NN	denotes	En1
T10364	48337-48341	NNS	denotes	mice
T10365	48330-48336	NN	denotes	mutant
T10366	48345-48354	JJ	denotes	unrelated
T10367	48355-48357	IN	denotes	to
T10368	48358-48365	NN	denotes	pigment
T10369	48366-48370	NN	denotes	type
T10370	48365-48366	HYPH	denotes	-
T10371	48371-48380	NN	denotes	synthesis
T10372	48381-48384	CC	denotes	and
T10373	48385-48392	RB	denotes	instead
T10374	48400-48408	VBZ	denotes	reflects
T10375	48393-48399	RB	denotes	likely
T10376	48409-48410	DT	denotes	a
T10377	48411-48422	NN	denotes	requirement
T10378	48423-48426	IN	denotes	for
T10379	48427-48430	NN	denotes	En1
T10380	48430-48432	,	denotes	,
T10381	48432-48443	JJ	denotes	independent
T10382	48444-48446	IN	denotes	of
T10383	48447-48452	NN	denotes	Wnt7a
T10384	48452-48454	,	denotes	,
T10385	48454-48456	TO	denotes	to
T10386	48457-48464	VB	denotes	repress
T10387	48465-48474	NN	denotes	migration
T10388	48475-48477	CC	denotes	or
T10389	48478-48491	NN	denotes	proliferation
T10390	48492-48493	-LRB-	denotes	(
T10391	48493-48495	CC	denotes	or
T10392	48496-48500	DT	denotes	both
T10393	48500-48501	-RRB-	denotes	)
T10394	48502-48504	IN	denotes	of
T10395	48505-48512	NN	denotes	pigment
T10396	48513-48518	NNS	denotes	cells
T10397	48519-48521	IN	denotes	in
T10398	48522-48529	JJ	denotes	ventral
T10399	48530-48539	NN	denotes	epidermis
T10400	48540-48541	-LRB-	denotes	[
T10401	48541-48546	NNP	denotes	Cygan
T10402	48547-48549	FW	denotes	et
T10403	48550-48553	FW	denotes	al.
T10404	48554-48558	CD	denotes	1997
T10405	48558-48559	:	denotes	;
T10406	48560-48566	NNP	denotes	Loomis
T10407	48567-48569	FW	denotes	et
T10408	48570-48573	FW	denotes	al.
T10409	48574-48578	CD	denotes	1998
T10410	48578-48579	-RRB-	denotes	]
T10411	48579-48580	.	denotes	.
T10412	48580-48581	-RRB-	denotes	)
T10413	48581-48939	sentence	denotes	These considerations notwithstanding, control of dorsoventral trunk pattern by Tbx15 shares certain features with control of dorsoventral limb patterning by Lmx1b, a LIM domain transcription factor that acts downstream of Wnt7a and En1 (Riddle et al. 1995; Vogel et al. 1995; Cygan et al. 1997; Logan et al. 1997; Loomis et al. 1998; Chen and Johnson 2002).
T10414	48582-48587	DT	denotes	These
T10415	48588-48602	NNS	denotes	considerations
T10416	48603-48618	RB	denotes	notwithstanding
T10417	48667-48673	VBZ	denotes	shares
T10418	48618-48620	,	denotes	,
T10419	48620-48627	NN	denotes	control
T10420	48628-48630	IN	denotes	of
T10421	48631-48643	JJ	denotes	dorsoventral
T10422	48650-48657	NN	denotes	pattern
T10423	48644-48649	NN	denotes	trunk
T10424	48658-48660	IN	denotes	by
T10425	48661-48666	NN	denotes	Tbx15
T10426	48674-48681	JJ	denotes	certain
T10427	48682-48690	NNS	denotes	features
T10428	48691-48695	IN	denotes	with
T10429	48696-48703	NN	denotes	control
T10430	48704-48706	IN	denotes	of
T10431	48707-48719	JJ	denotes	dorsoventral
T10432	48725-48735	NN	denotes	patterning
T10433	48720-48724	NN	denotes	limb
T10434	48736-48738	IN	denotes	by
T10435	48739-48744	NN	denotes	Lmx1b
T10436	48744-48746	,	denotes	,
T10437	48746-48747	DT	denotes	a
T10438	48773-48779	NN	denotes	factor
T10439	48748-48751	NN	denotes	LIM
T10440	48752-48758	NN	denotes	domain
T10441	48759-48772	NN	denotes	transcription
T10442	48780-48784	WDT	denotes	that
T10443	48785-48789	VBZ	denotes	acts
T10444	48790-48800	RB	denotes	downstream
T10445	48801-48803	IN	denotes	of
T10446	48804-48809	NN	denotes	Wnt7a
T10447	48810-48813	CC	denotes	and
T10448	48814-48817	NN	denotes	En1
T10449	48818-48819	-LRB-	denotes	(
T10450	48819-48825	NNP	denotes	Riddle
T10451	48826-48828	FW	denotes	et
T10452	48829-48832	FW	denotes	al.
T10453	48833-48837	CD	denotes	1995
T10454	48837-48838	:	denotes	;
T10455	48839-48844	NNP	denotes	Vogel
T10456	48845-48847	FW	denotes	et
T10457	48848-48851	FW	denotes	al.
T10458	48852-48856	CD	denotes	1995
T10459	48856-48857	:	denotes	;
T10460	48858-48863	NNP	denotes	Cygan
T10461	48864-48866	FW	denotes	et
T10462	48867-48870	FW	denotes	al.
T10463	48871-48875	CD	denotes	1997
T10464	48875-48876	:	denotes	;
T10465	48877-48882	NNP	denotes	Logan
T10466	48883-48885	FW	denotes	et
T10467	48886-48889	FW	denotes	al.
T10468	48890-48894	CD	denotes	1997
T10469	48894-48895	:	denotes	;
T10470	48896-48902	NNP	denotes	Loomis
T10471	48903-48905	FW	denotes	et
T10472	48906-48909	FW	denotes	al.
T10473	48910-48914	CD	denotes	1998
T10474	48914-48915	:	denotes	;
T10475	48916-48920	NNP	denotes	Chen
T10476	48921-48924	CC	denotes	and
T10477	48925-48932	NNP	denotes	Johnson
T10478	48933-48937	CD	denotes	2002
T10479	48937-48938	-RRB-	denotes	)
T10480	48938-48939	.	denotes	.
T10481	48939-49193	sentence	denotes	Both Tbx15 and Lmx1b act autonomously in mesenchymal cells to promote a dorsal identity, yet have expression domains that do not correspond to cell lineage compartments in the flank (Tbx15) or the limb (Lmx1b) (Altabef et al. 1997; Michaud et al. 1997).
T10482	48940-48944	CC	denotes	Both
T10483	48945-48950	NN	denotes	Tbx15
T10484	48961-48964	VBP	denotes	act
T10485	48951-48954	CC	denotes	and
T10486	48955-48960	NN	denotes	Lmx1b
T10487	48965-48977	RB	denotes	autonomously
T10488	48978-48980	IN	denotes	in
T10489	48981-48992	JJ	denotes	mesenchymal
T10490	48993-48998	NNS	denotes	cells
T10491	48999-49001	TO	denotes	to
T10492	49002-49009	VB	denotes	promote
T10493	49010-49011	DT	denotes	a
T10494	49019-49027	NN	denotes	identity
T10495	49012-49018	JJ	denotes	dorsal
T10496	49027-49029	,	denotes	,
T10497	49029-49032	CC	denotes	yet
T10498	49033-49037	VBP	denotes	have
T10499	49038-49048	NN	denotes	expression
T10500	49049-49056	NNS	denotes	domains
T10501	49057-49061	WDT	denotes	that
T10502	49069-49079	VB	denotes	correspond
T10503	49062-49064	VBP	denotes	do
T10504	49065-49068	RB	denotes	not
T10505	49080-49082	IN	denotes	to
T10506	49083-49087	NN	denotes	cell
T10507	49088-49095	NN	denotes	lineage
T10508	49096-49108	NNS	denotes	compartments
T10509	49109-49111	IN	denotes	in
T10510	49112-49115	DT	denotes	the
T10511	49116-49121	NN	denotes	flank
T10512	49122-49123	-LRB-	denotes	(
T10513	49123-49128	NN	denotes	Tbx15
T10514	49128-49129	-RRB-	denotes	)
T10515	49130-49132	CC	denotes	or
T10516	49133-49136	DT	denotes	the
T10517	49137-49141	NN	denotes	limb
T10518	49142-49143	-LRB-	denotes	(
T10519	49143-49148	NN	denotes	Lmx1b
T10520	49148-49149	-RRB-	denotes	)
T10521	49150-49151	-LRB-	denotes	(
T10522	49151-49158	NNP	denotes	Altabef
T10523	49159-49161	FW	denotes	et
T10524	49162-49165	FW	denotes	al.
T10525	49166-49170	CD	denotes	1997
T10526	49170-49171	:	denotes	;
T10527	49172-49179	NNP	denotes	Michaud
T10528	49180-49182	FW	denotes	et
T10529	49183-49186	FW	denotes	al.
T10530	49187-49191	CD	denotes	1997
T10531	49191-49192	-RRB-	denotes	)
T10532	49192-49193	.	denotes	.
T10533	49193-49369	sentence	denotes	In the case of Lmx1b, its expression in the distal limb depends on Wnt7a produced in the overlying dorsal ectoderm (Riddle et al. 1995; Cygan et al. 1997; Loomis et al. 1998).
T10534	49194-49196	IN	denotes	In
T10535	49250-49257	VBZ	denotes	depends
T10536	49197-49200	DT	denotes	the
T10537	49201-49205	NN	denotes	case
T10538	49206-49208	IN	denotes	of
T10539	49209-49214	NN	denotes	Lmx1b
T10540	49214-49216	,	denotes	,
T10541	49216-49219	PRP$	denotes	its
T10542	49220-49230	NN	denotes	expression
T10543	49231-49233	IN	denotes	in
T10544	49234-49237	DT	denotes	the
T10545	49245-49249	NN	denotes	limb
T10546	49238-49244	JJ	denotes	distal
T10547	49258-49260	IN	denotes	on
T10548	49261-49266	NN	denotes	Wnt7a
T10549	49267-49275	VBN	denotes	produced
T10550	49276-49278	IN	denotes	in
T10551	49279-49282	DT	denotes	the
T10552	49300-49308	NN	denotes	ectoderm
T10553	49283-49292	VBG	denotes	overlying
T10554	49293-49299	JJ	denotes	dorsal
T10555	49309-49310	-LRB-	denotes	(
T10556	49310-49316	NNP	denotes	Riddle
T10557	49317-49319	FW	denotes	et
T10558	49320-49323	FW	denotes	al.
T10559	49324-49328	CD	denotes	1995
T10560	49328-49329	:	denotes	;
T10561	49330-49335	NNP	denotes	Cygan
T10562	49336-49338	FW	denotes	et
T10563	49339-49342	FW	denotes	al.
T10564	49343-49347	CD	denotes	1997
T10565	49347-49348	:	denotes	;
T10566	49349-49355	NNP	denotes	Loomis
T10567	49356-49358	FW	denotes	et
T10568	49359-49362	FW	denotes	al.
T10569	49363-49367	CD	denotes	1998
T10570	49367-49368	-RRB-	denotes	)
T10571	49368-49369	.	denotes	.
T10572	49369-49687	sentence	denotes	Wnt7a, in turn, is restricted to dorsal ectoderm by En1 in the ventral ectoderm (Loomis et al. 1996; Cygan et al. 1997; Logan et al. 1997), whose expression marks a lineage boundary coincident with the dorsoventral midline of the apical ectodermal ridge (Altabef et al. 1997; Michaud et al. 1997; Kimmel et al. 2000).
T10573	49370-49375	NN	denotes	Wnt7a
T10574	49389-49399	VBN	denotes	restricted
T10575	49375-49377	,	denotes	,
T10576	49377-49379	IN	denotes	in
T10577	49380-49384	NN	denotes	turn
T10578	49384-49386	,	denotes	,
T10579	49386-49388	VBZ	denotes	is
T10580	49400-49402	IN	denotes	to
T10581	49403-49409	JJ	denotes	dorsal
T10582	49410-49418	NN	denotes	ectoderm
T10583	49419-49421	IN	denotes	by
T10584	49422-49425	NN	denotes	En1
T10585	49426-49428	IN	denotes	in
T10586	49429-49432	DT	denotes	the
T10587	49441-49449	NN	denotes	ectoderm
T10588	49433-49440	JJ	denotes	ventral
T10589	49450-49451	-LRB-	denotes	(
T10590	49451-49457	NNP	denotes	Loomis
T10591	49458-49460	FW	denotes	et
T10592	49461-49464	FW	denotes	al.
T10593	49465-49469	CD	denotes	1996
T10594	49469-49470	:	denotes	;
T10595	49471-49476	NNP	denotes	Cygan
T10596	49477-49479	FW	denotes	et
T10597	49480-49483	FW	denotes	al.
T10598	49484-49488	CD	denotes	1997
T10599	49488-49489	:	denotes	;
T10600	49490-49495	NNP	denotes	Logan
T10601	49496-49498	FW	denotes	et
T10602	49499-49502	FW	denotes	al.
T10603	49503-49507	CD	denotes	1997
T10604	49507-49508	-RRB-	denotes	)
T10605	49508-49510	,	denotes	,
T10606	49510-49515	WP$	denotes	whose
T10607	49516-49526	NN	denotes	expression
T10608	49527-49532	VBZ	denotes	marks
T10609	49533-49534	DT	denotes	a
T10610	49543-49551	NN	denotes	boundary
T10611	49535-49542	NN	denotes	lineage
T10612	49552-49562	JJ	denotes	coincident
T10613	49563-49567	IN	denotes	with
T10614	49568-49571	DT	denotes	the
T10615	49585-49592	NN	denotes	midline
T10616	49572-49584	JJ	denotes	dorsoventral
T10617	49593-49595	IN	denotes	of
T10618	49596-49599	DT	denotes	the
T10619	49618-49623	NN	denotes	ridge
T10620	49600-49606	JJ	denotes	apical
T10621	49607-49617	JJ	denotes	ectodermal
T10622	49624-49625	-LRB-	denotes	(
T10623	49646-49653	NNP	denotes	Michaud
T10624	49625-49632	NN	denotes	Altabef
T10625	49633-49635	FW	denotes	et
T10626	49636-49639	FW	denotes	al.
T10627	49640-49644	CD	denotes	1997
T10628	49644-49645	:	denotes	;
T10629	49654-49656	FW	denotes	et
T10630	49657-49660	FW	denotes	al.
T10631	49661-49665	CD	denotes	1997
T10632	49665-49666	:	denotes	;
T10633	49667-49673	NNP	denotes	Kimmel
T10634	49674-49676	FW	denotes	et
T10635	49677-49680	FW	denotes	al.
T10636	49681-49685	CD	denotes	2000
T10637	49685-49686	-RRB-	denotes	)
T10638	49686-49687	.	denotes	.
T10639	49687-49879	sentence	denotes	As described above, En1 or Wnt7a mutations have not been reported to affect patterns of hair-color distribution (C. Loomis, personal communication; Parr and McMahon 1995; Loomis et al. 1996).
T10640	49688-49690	IN	denotes	As
T10641	49691-49700	VBN	denotes	described
T10642	49745-49753	VBN	denotes	reported
T10643	49701-49706	RB	denotes	above
T10644	49706-49708	,	denotes	,
T10645	49708-49711	NN	denotes	En1
T10646	49721-49730	NNS	denotes	mutations
T10647	49712-49714	CC	denotes	or
T10648	49715-49720	NN	denotes	Wnt7a
T10649	49731-49735	VBP	denotes	have
T10650	49736-49739	RB	denotes	not
T10651	49740-49744	VBN	denotes	been
T10652	49754-49756	TO	denotes	to
T10653	49757-49763	VB	denotes	affect
T10654	49764-49772	NNS	denotes	patterns
T10655	49773-49775	IN	denotes	of
T10656	49776-49780	NN	denotes	hair
T10657	49781-49786	NN	denotes	color
T10658	49780-49781	HYPH	denotes	-
T10659	49787-49799	NN	denotes	distribution
T10660	49800-49801	-LRB-	denotes	(
T10661	49801-49803	NNP	denotes	C.
T10662	49804-49810	NNP	denotes	Loomis
T10663	49810-49812	,	denotes	,
T10664	49812-49820	JJ	denotes	personal
T10665	49821-49834	NN	denotes	communication
T10666	49834-49835	:	denotes	;
T10667	49836-49840	NNP	denotes	Parr
T10668	49841-49844	CC	denotes	and
T10669	49845-49852	NNP	denotes	McMahon
T10670	49853-49857	CD	denotes	1995
T10671	49857-49858	:	denotes	;
T10672	49859-49865	NNP	denotes	Loomis
T10673	49866-49868	FW	denotes	et
T10674	49869-49872	RB	denotes	al.
T10675	49873-49877	CD	denotes	1996
T10676	49877-49878	-RRB-	denotes	)
T10677	49878-49879	.	denotes	.
T10678	49879-50051	sentence	denotes	However, the essential theme that ectodermal lineage compartments control the fate of underlying mesenchyme in developing limbs may apply to the trunk as well as the limb.
T10679	49880-49887	RB	denotes	However
T10680	50012-50017	VB	denotes	apply
T10681	49887-49889	,	denotes	,
T10682	49889-49892	DT	denotes	the
T10683	49903-49908	NN	denotes	theme
T10684	49893-49902	JJ	denotes	essential
T10685	49909-49913	IN	denotes	that
T10686	49946-49953	VBP	denotes	control
T10687	49914-49924	JJ	denotes	ectodermal
T10688	49933-49945	NNS	denotes	compartments
T10689	49925-49932	NN	denotes	lineage
T10690	49954-49957	DT	denotes	the
T10691	49958-49962	NN	denotes	fate
T10692	49963-49965	IN	denotes	of
T10693	49966-49976	VBG	denotes	underlying
T10694	49977-49987	NN	denotes	mesenchyme
T10695	49988-49990	IN	denotes	in
T10696	49991-50001	VBG	denotes	developing
T10697	50002-50007	NNS	denotes	limbs
T10698	50008-50011	MD	denotes	may
T10699	50018-50020	IN	denotes	to
T10700	50021-50024	DT	denotes	the
T10701	50025-50030	NN	denotes	trunk
T10702	50031-50033	RB	denotes	as
T10703	50039-50041	IN	denotes	as
T10704	50034-50038	RB	denotes	well
T10705	50042-50045	DT	denotes	the
T10706	50046-50050	NN	denotes	limb
T10707	50050-50051	.	denotes	.
T10708	50051-50173	sentence	denotes	The mammary glands also develop at a stereotyped dorsoventral position and depend on epithelial–mesenchymal interactions.
T10709	50052-50055	DT	denotes	The
T10710	50064-50070	NNS	denotes	glands
T10711	50056-50063	JJ	denotes	mammary
T10712	50076-50083	VBP	denotes	develop
T10713	50071-50075	RB	denotes	also
T10714	50084-50086	IN	denotes	at
T10715	50087-50088	DT	denotes	a
T10716	50114-50122	NN	denotes	position
T10717	50089-50100	JJ	denotes	stereotyped
T10718	50101-50113	JJ	denotes	dorsoventral
T10719	50123-50126	CC	denotes	and
T10720	50127-50133	VBP	denotes	depend
T10721	50134-50136	IN	denotes	on
T10722	50137-50147	JJ	denotes	epithelial
T10723	50148-50159	JJ	denotes	mesenchymal
T10724	50147-50148	HYPH	denotes	–
T10725	50160-50172	NNS	denotes	interactions
T10726	50172-50173	.	denotes	.
T10727	50173-50393	sentence	denotes	However, the number and apparent position of the mammary glands are normal in deH/deH animals, indicating the existence of additional mechanisms that control dorsoventral patterning in the trunk as well as in the limbs.
T10728	50174-50181	RB	denotes	However
T10729	50238-50241	VBP	denotes	are
T10730	50181-50183	,	denotes	,
T10731	50183-50186	DT	denotes	the
T10732	50187-50193	NN	denotes	number
T10733	50194-50197	CC	denotes	and
T10734	50198-50206	JJ	denotes	apparent
T10735	50207-50215	NN	denotes	position
T10736	50216-50218	IN	denotes	of
T10737	50219-50222	DT	denotes	the
T10738	50231-50237	NNS	denotes	glands
T10739	50223-50230	JJ	denotes	mammary
T10740	50242-50248	JJ	denotes	normal
T10741	50249-50251	IN	denotes	in
T10742	50252-50255	NN	denotes	deH
T10743	50256-50259	NN	denotes	deH
T10744	50255-50256	HYPH	denotes	/
T10745	50260-50267	NNS	denotes	animals
T10746	50267-50269	,	denotes	,
T10747	50269-50279	VBG	denotes	indicating
T10748	50280-50283	DT	denotes	the
T10749	50284-50293	NN	denotes	existence
T10750	50294-50296	IN	denotes	of
T10751	50297-50307	JJ	denotes	additional
T10752	50308-50318	NNS	denotes	mechanisms
T10753	50319-50323	WDT	denotes	that
T10754	50324-50331	VBP	denotes	control
T10755	50332-50344	JJ	denotes	dorsoventral
T10756	50345-50355	NN	denotes	patterning
T10757	50356-50358	IN	denotes	in
T10758	50359-50362	DT	denotes	the
T10759	50363-50368	NN	denotes	trunk
T10760	50369-50371	RB	denotes	as
T10761	50377-50379	IN	denotes	as
T10762	50372-50376	RB	denotes	well
T10763	50380-50382	IN	denotes	in
T10764	50383-50386	DT	denotes	the
T10765	50387-50392	NNS	denotes	limbs
T10766	50392-50393	.	denotes	.
T10767	50393-50453	sentence	denotes	These ideas are summarized in the model shown in Figure 9B.
T10768	50394-50399	DT	denotes	These
T10769	50400-50405	NNS	denotes	ideas
T10770	50410-50420	VBN	denotes	summarized
T10771	50406-50409	VBP	denotes	are
T10772	50421-50423	IN	denotes	in
T10773	50424-50427	DT	denotes	the
T10774	50428-50433	NN	denotes	model
T10775	50434-50439	VBN	denotes	shown
T10776	50440-50442	IN	denotes	in
T10777	50443-50449	NN	denotes	Figure
T10778	50450-50452	CD	denotes	9B
T10779	50452-50453	.	denotes	.
T10780	50453-50757	sentence	denotes	We speculate that a diffusible signal from dorsal trunk ectoderm, at or prior to E11.5, promotes expression of Tbx15 in dorsal trunk mesenchyme, which then establishes dorsal positional identity of those cells as manifested by differences in Agouti expression, pigment-cell development, and hair growth.
T10781	50454-50456	PRP	denotes	We
T10782	50457-50466	VBP	denotes	speculate
T10783	50467-50471	IN	denotes	that
T10784	50542-50550	VBZ	denotes	promotes
T10785	50472-50473	DT	denotes	a
T10786	50485-50491	NN	denotes	signal
T10787	50474-50484	JJ	denotes	diffusible
T10788	50492-50496	IN	denotes	from
T10789	50497-50503	JJ	denotes	dorsal
T10790	50510-50518	NN	denotes	ectoderm
T10791	50504-50509	NN	denotes	trunk
T10792	50518-50520	,	denotes	,
T10793	50520-50522	IN	denotes	at
T10794	50523-50525	CC	denotes	or
T10795	50526-50531	RB	denotes	prior
T10796	50535-50540	NN	denotes	E11.5
T10797	50532-50534	IN	denotes	to
T10798	50540-50542	,	denotes	,
T10799	50551-50561	NN	denotes	expression
T10800	50562-50564	IN	denotes	of
T10801	50565-50570	NN	denotes	Tbx15
T10802	50571-50573	IN	denotes	in
T10803	50574-50580	JJ	denotes	dorsal
T10804	50587-50597	NN	denotes	mesenchyme
T10805	50581-50586	NN	denotes	trunk
T10806	50597-50599	,	denotes	,
T10807	50599-50604	WDT	denotes	which
T10808	50610-50621	VBZ	denotes	establishes
T10809	50605-50609	RB	denotes	then
T10810	50622-50628	JJ	denotes	dorsal
T10811	50640-50648	NN	denotes	identity
T10812	50629-50639	JJ	denotes	positional
T10813	50649-50651	IN	denotes	of
T10814	50652-50657	DT	denotes	those
T10815	50658-50663	NNS	denotes	cells
T10816	50664-50666	IN	denotes	as
T10817	50667-50677	VBN	denotes	manifested
T10818	50678-50680	IN	denotes	by
T10819	50681-50692	NNS	denotes	differences
T10820	50693-50695	IN	denotes	in
T10821	50696-50702	NN	denotes	Agouti
T10822	50703-50713	NN	denotes	expression
T10823	50713-50715	,	denotes	,
T10824	50715-50722	NN	denotes	pigment
T10825	50723-50727	NN	denotes	cell
T10826	50722-50723	HYPH	denotes	-
T10827	50728-50739	NN	denotes	development
T10828	50739-50741	,	denotes	,
T10829	50741-50744	CC	denotes	and
T10830	50745-50749	NN	denotes	hair
T10831	50750-50756	NN	denotes	growth
T10832	50756-50757	.	denotes	.
T10833	50757-51103	sentence	denotes	Because the ventral limit of Tbx15 expression corresponds to the dorsal limit of En1 expression and because the normal position of the pigmentation boundary lies approximately in register with the limb-bud outgrowths, we depict the position of a putative dorsoventral boundary in trunk ectoderm as coincident with the limb dorsoventral boundary.
T10834	50758-50765	IN	denotes	Because
T10835	50804-50815	VBZ	denotes	corresponds
T10836	50766-50769	DT	denotes	the
T10837	50778-50783	NN	denotes	limit
T10838	50770-50777	JJ	denotes	ventral
T10839	50784-50786	IN	denotes	of
T10840	50787-50792	NN	denotes	Tbx15
T10841	50793-50803	NN	denotes	expression
T10842	50979-50985	VBP	denotes	depict
T10843	50816-50818	IN	denotes	to
T10844	50819-50822	DT	denotes	the
T10845	50830-50835	NN	denotes	limit
T10846	50823-50829	JJ	denotes	dorsal
T10847	50836-50838	IN	denotes	of
T10848	50839-50842	NN	denotes	En1
T10849	50843-50853	NN	denotes	expression
T10850	50854-50857	CC	denotes	and
T10851	50858-50865	IN	denotes	because
T10852	50915-50919	VBZ	denotes	lies
T10853	50866-50869	DT	denotes	the
T10854	50877-50885	NN	denotes	position
T10855	50870-50876	JJ	denotes	normal
T10856	50886-50888	IN	denotes	of
T10857	50889-50892	DT	denotes	the
T10858	50906-50914	NN	denotes	boundary
T10859	50893-50905	NN	denotes	pigmentation
T10860	50920-50933	RB	denotes	approximately
T10861	50934-50936	IN	denotes	in
T10862	50937-50945	NN	denotes	register
T10863	50946-50950	IN	denotes	with
T10864	50951-50954	DT	denotes	the
T10865	50964-50974	NNS	denotes	outgrowths
T10866	50955-50959	NN	denotes	limb
T10867	50960-50963	NN	denotes	bud
T10868	50959-50960	HYPH	denotes	-
T10869	50974-50976	,	denotes	,
T10870	50976-50978	PRP	denotes	we
T10871	50986-50989	DT	denotes	the
T10872	50990-50998	NN	denotes	position
T10873	50999-51001	IN	denotes	of
T10874	51002-51003	DT	denotes	a
T10875	51026-51034	NN	denotes	boundary
T10876	51004-51012	JJ	denotes	putative
T10877	51013-51025	JJ	denotes	dorsoventral
T10878	51035-51037	IN	denotes	in
T10879	51038-51043	NN	denotes	trunk
T10880	51044-51052	NN	denotes	ectoderm
T10881	51053-51055	IN	denotes	as
T10882	51056-51066	JJ	denotes	coincident
T10883	51067-51071	IN	denotes	with
T10884	51072-51075	DT	denotes	the
T10885	51094-51102	NN	denotes	boundary
T10886	51076-51080	NN	denotes	limb
T10887	51081-51093	JJ	denotes	dorsoventral
T10888	51102-51103	.	denotes	.
T10889	51103-51436	sentence	denotes	This model is consistent with studies in the chick, where distinct dorsal and ventral lineage compartments exist for ectoderm in both the limb (Altabef et al. 1997, 2000; Michaud et al. 1997; Kimmel et al. 2000) and interlimb regions (Altabef et al. 1997, 2000), but not for limb mesoderm (Altabef et al. 1997; Michaud et al. 1997).
T10890	51104-51108	DT	denotes	This
T10891	51109-51114	NN	denotes	model
T10892	51115-51117	VBZ	denotes	is
T10893	51118-51128	JJ	denotes	consistent
T10894	51129-51133	IN	denotes	with
T10895	51134-51141	NNS	denotes	studies
T10896	51142-51144	IN	denotes	in
T10897	51145-51148	DT	denotes	the
T10898	51149-51154	NN	denotes	chick
T10899	51154-51156	,	denotes	,
T10900	51156-51161	WRB	denotes	where
T10901	51211-51216	VBP	denotes	exist
T10902	51162-51170	JJ	denotes	distinct
T10903	51198-51210	NNS	denotes	compartments
T10904	51171-51177	JJ	denotes	dorsal
T10905	51178-51181	CC	denotes	and
T10906	51182-51189	JJ	denotes	ventral
T10907	51190-51197	NN	denotes	lineage
T10908	51217-51220	IN	denotes	for
T10909	51221-51229	NN	denotes	ectoderm
T10910	51230-51232	IN	denotes	in
T10911	51233-51237	CC	denotes	both
T10912	51242-51246	NN	denotes	limb
T10913	51238-51241	DT	denotes	the
T10914	51247-51248	-LRB-	denotes	(
T10915	51275-51282	NNP	denotes	Michaud
T10916	51248-51255	NN	denotes	Altabef
T10917	51256-51258	FW	denotes	et
T10918	51259-51262	FW	denotes	al.
T10919	51263-51267	CD	denotes	1997
T10920	51267-51269	,	denotes	,
T10921	51269-51273	CD	denotes	2000
T10922	51273-51274	:	denotes	;
T10923	51283-51285	FW	denotes	et
T10924	51286-51289	FW	denotes	al.
T10925	51290-51294	CD	denotes	1997
T10926	51294-51295	:	denotes	;
T10927	51296-51302	NNP	denotes	Kimmel
T10928	51303-51305	FW	denotes	et
T10929	51306-51309	FW	denotes	al.
T10930	51310-51314	CD	denotes	2000
T10931	51314-51315	-RRB-	denotes	)
T10932	51316-51319	CC	denotes	and
T10933	51320-51329	JJ	denotes	interlimb
T10934	51330-51337	NNS	denotes	regions
T10935	51338-51339	-LRB-	denotes	(
T10936	51339-51346	NNP	denotes	Altabef
T10937	51347-51349	FW	denotes	et
T10938	51350-51353	FW	denotes	al.
T10939	51354-51358	CD	denotes	1997
T10940	51358-51360	,	denotes	,
T10941	51360-51364	CD	denotes	2000
T10942	51364-51365	-RRB-	denotes	)
T10943	51365-51367	,	denotes	,
T10944	51367-51370	CC	denotes	but
T10945	51375-51378	IN	denotes	for
T10946	51371-51374	RB	denotes	not
T10947	51379-51383	NN	denotes	limb
T10948	51384-51392	NN	denotes	mesoderm
T10949	51393-51394	-LRB-	denotes	(
T10950	51394-51401	NNP	denotes	Altabef
T10951	51402-51404	FW	denotes	et
T10952	51405-51408	FW	denotes	al.
T10953	51409-51413	CD	denotes	1997
T10954	51413-51414	:	denotes	;
T10955	51415-51422	NNP	denotes	Michaud
T10956	51423-51425	FW	denotes	et
T10957	51426-51429	FW	denotes	al.
T10958	51430-51434	CD	denotes	1997
T10959	51434-51435	-RRB-	denotes	)
T10960	51435-51436	.	denotes	.
T10961	51436-51873	sentence	denotes	In fact, the same mechanism that determines dorsoventral position of the limbs and the apical ectodermal ridge may also act on expression of Tbx15 in the trunk, since ectopic limbs induced in the interlimb region by application of FGF beads develop along a single line that is coincident with normal limb buds (and the future pigmentation boundary) (Cohn et al. 1995; Crossley et al. 1996; Vogel et al. 1996; Altabef et al. 1997, 2000).
T10962	51437-51439	IN	denotes	In
T10963	51557-51560	VB	denotes	act
T10964	51440-51444	NN	denotes	fact
T10965	51444-51446	,	denotes	,
T10966	51446-51449	DT	denotes	the
T10967	51455-51464	NN	denotes	mechanism
T10968	51450-51454	JJ	denotes	same
T10969	51465-51469	WDT	denotes	that
T10970	51470-51480	VBZ	denotes	determines
T10971	51481-51493	JJ	denotes	dorsoventral
T10972	51494-51502	NN	denotes	position
T10973	51503-51505	IN	denotes	of
T10974	51506-51509	DT	denotes	the
T10975	51510-51515	NNS	denotes	limbs
T10976	51516-51519	CC	denotes	and
T10977	51520-51523	DT	denotes	the
T10978	51542-51547	NN	denotes	ridge
T10979	51524-51530	JJ	denotes	apical
T10980	51531-51541	JJ	denotes	ectodermal
T10981	51548-51551	MD	denotes	may
T10982	51552-51556	RB	denotes	also
T10983	51561-51563	IN	denotes	on
T10984	51564-51574	NN	denotes	expression
T10985	51575-51577	IN	denotes	of
T10986	51578-51583	NN	denotes	Tbx15
T10987	51584-51586	IN	denotes	in
T10988	51587-51590	DT	denotes	the
T10989	51591-51596	NN	denotes	trunk
T10990	51596-51598	,	denotes	,
T10991	51598-51603	IN	denotes	since
T10992	51678-51685	VBP	denotes	develop
T10993	51604-51611	JJ	denotes	ectopic
T10994	51612-51617	NNS	denotes	limbs
T10995	51618-51625	VBN	denotes	induced
T10996	51626-51628	IN	denotes	in
T10997	51629-51632	DT	denotes	the
T10998	51643-51649	NN	denotes	region
T10999	51633-51642	JJ	denotes	interlimb
T11000	51650-51652	IN	denotes	by
T11001	51653-51664	NN	denotes	application
T11002	51665-51667	IN	denotes	of
T11003	51668-51671	NN	denotes	FGF
T11004	51672-51677	NNS	denotes	beads
T11005	51686-51691	IN	denotes	along
T11006	51692-51693	DT	denotes	a
T11007	51701-51705	NN	denotes	line
T11008	51694-51700	JJ	denotes	single
T11009	51706-51710	WDT	denotes	that
T11010	51711-51713	VBZ	denotes	is
T11011	51714-51724	JJ	denotes	coincident
T11012	51725-51729	IN	denotes	with
T11013	51730-51736	JJ	denotes	normal
T11014	51742-51746	NNS	denotes	buds
T11015	51737-51741	NN	denotes	limb
T11016	51747-51748	-LRB-	denotes	(
T11017	51748-51751	CC	denotes	and
T11018	51752-51755	DT	denotes	the
T11019	51776-51784	NN	denotes	boundary
T11020	51756-51762	JJ	denotes	future
T11021	51763-51775	NN	denotes	pigmentation
T11022	51784-51785	-RRB-	denotes	)
T11023	51786-51787	-LRB-	denotes	(
T11024	51787-51791	NNP	denotes	Cohn
T11025	51792-51794	FW	denotes	et
T11026	51795-51798	FW	denotes	al.
T11027	51799-51803	CD	denotes	1995
T11028	51803-51804	:	denotes	;
T11029	51805-51813	NNP	denotes	Crossley
T11030	51814-51816	FW	denotes	et
T11031	51817-51820	FW	denotes	al.
T11032	51821-51825	CD	denotes	1996
T11033	51825-51826	:	denotes	;
T11034	51827-51832	NNP	denotes	Vogel
T11035	51833-51835	FW	denotes	et
T11036	51836-51839	FW	denotes	al.
T11037	51840-51844	CD	denotes	1996
T11038	51844-51845	:	denotes	;
T11039	51846-51853	NNP	denotes	Altabef
T11040	51854-51856	FW	denotes	et
T11041	51857-51860	FW	denotes	al.
T11042	51861-51865	CD	denotes	1997
T11043	51865-51867	,	denotes	,
T11044	51867-51871	CD	denotes	2000
T11045	51871-51872	-RRB-	denotes	)
T11046	51872-51873	.	denotes	.
T11047	51873-52057	sentence	denotes	Our model predicts that ectopic expression of Tbx15 in ventral mesenchyme should give rise to a dorsalized pigmentation phenotype and could be tested with gain-of-function approaches.
T11048	51874-51877	PRP$	denotes	Our
T11049	51878-51883	NN	denotes	model
T11050	51884-51892	VBZ	denotes	predicts
T11051	51893-51897	IN	denotes	that
T11052	51955-51959	VB	denotes	give
T11053	51898-51905	JJ	denotes	ectopic
T11054	51906-51916	NN	denotes	expression
T11055	51917-51919	IN	denotes	of
T11056	51920-51925	NN	denotes	Tbx15
T11057	51926-51928	IN	denotes	in
T11058	51929-51936	JJ	denotes	ventral
T11059	51937-51947	NN	denotes	mesenchyme
T11060	51948-51954	MD	denotes	should
T11061	51960-51964	NN	denotes	rise
T11062	51965-51967	IN	denotes	to
T11063	51968-51969	DT	denotes	a
T11064	51994-52003	NN	denotes	phenotype
T11065	51970-51980	JJ	denotes	dorsalized
T11066	51981-51993	NN	denotes	pigmentation
T11067	52004-52007	CC	denotes	and
T11068	52008-52013	MD	denotes	could
T11069	52017-52023	VBN	denotes	tested
T11070	52014-52016	VB	denotes	be
T11071	52024-52028	IN	denotes	with
T11072	52029-52033	NN	denotes	gain
T11073	52046-52056	NNS	denotes	approaches
T11074	52033-52034	HYPH	denotes	-
T11075	52034-52036	IN	denotes	of
T11076	52036-52037	HYPH	denotes	-
T11077	52037-52045	NN	denotes	function
T11078	52056-52057	.	denotes	.
T11079	52057-52162	sentence	denotes	However, Tbx15 expression is very dynamic and is restricted to dorsal mesoderm only from E11.5 to E13.5.
T11080	52058-52065	RB	denotes	However
T11081	52084-52086	VBZ	denotes	is
T11082	52065-52067	,	denotes	,
T11083	52067-52072	NN	denotes	Tbx15
T11084	52073-52083	NN	denotes	expression
T11085	52087-52091	RB	denotes	very
T11086	52092-52099	JJ	denotes	dynamic
T11087	52100-52103	CC	denotes	and
T11088	52104-52106	VBZ	denotes	is
T11089	52107-52117	VBN	denotes	restricted
T11090	52118-52120	IN	denotes	to
T11091	52121-52127	JJ	denotes	dorsal
T11092	52128-52136	NN	denotes	mesoderm
T11093	52137-52141	RB	denotes	only
T11094	52142-52146	IN	denotes	from
T11095	52147-52152	NN	denotes	E11.5
T11096	52153-52155	IN	denotes	to
T11097	52156-52161	NN	denotes	E13.5
T11098	52161-52162	.	denotes	.
T11099	52162-52426	sentence	denotes	It is possible that Tbx15 influences skin patterning in a very narrow window of development; alternatively, establishment of dorsal identity by Tbx15 may require another as-yet-unidentified factor that is only present in the mesenchyme underlying dorsal ectoderm.
T11100	52163-52165	PRP	denotes	It
T11101	52166-52168	VBZ	denotes	is
T11102	52317-52324	VB	denotes	require
T11103	52169-52177	JJ	denotes	possible
T11104	52178-52182	IN	denotes	that
T11105	52189-52199	VBZ	denotes	influences
T11106	52183-52188	NN	denotes	Tbx15
T11107	52200-52204	NN	denotes	skin
T11108	52205-52215	NN	denotes	patterning
T11109	52216-52218	IN	denotes	in
T11110	52219-52220	DT	denotes	a
T11111	52233-52239	NN	denotes	window
T11112	52221-52225	RB	denotes	very
T11113	52226-52232	JJ	denotes	narrow
T11114	52240-52242	IN	denotes	of
T11115	52243-52254	NN	denotes	development
T11116	52254-52255	:	denotes	;
T11117	52256-52269	RB	denotes	alternatively
T11118	52269-52271	,	denotes	,
T11119	52271-52284	NN	denotes	establishment
T11120	52285-52287	IN	denotes	of
T11121	52288-52294	JJ	denotes	dorsal
T11122	52295-52303	NN	denotes	identity
T11123	52304-52306	IN	denotes	by
T11124	52307-52312	NN	denotes	Tbx15
T11125	52313-52316	MD	denotes	may
T11126	52325-52332	DT	denotes	another
T11127	52353-52359	NN	denotes	factor
T11128	52333-52335	RB	denotes	as
T11129	52336-52339	RB	denotes	yet
T11130	52335-52336	HYPH	denotes	-
T11131	52340-52352	JJ	denotes	unidentified
T11132	52339-52340	HYPH	denotes	-
T11133	52360-52364	WDT	denotes	that
T11134	52365-52367	VBZ	denotes	is
T11135	52368-52372	RB	denotes	only
T11136	52373-52380	JJ	denotes	present
T11137	52381-52383	IN	denotes	in
T11138	52384-52387	DT	denotes	the
T11139	52388-52398	NN	denotes	mesenchyme
T11140	52399-52409	VBG	denotes	underlying
T11141	52410-52416	JJ	denotes	dorsal
T11142	52417-52425	NN	denotes	ectoderm
T11143	52425-52426	.	denotes	.
T11305	52428-52440	NN	denotes	Pigmentation
T11306	52441-52449	NNS	denotes	Patterns
T11307	52450-52453	CC	denotes	and
T11308	52454-52459	NN	denotes	Tbx15
T11309	52460-52462	IN	denotes	in
T11310	52463-52468	JJ	denotes	Other
T11311	52469-52476	NNS	denotes	Mammals
T11312	52476-52849	sentence	denotes	The lateral somitic frontier, defined as the lineage boundary between somite-derived versus lateral plate-derived mesoderm, is established during somitogenesis early in development (Mauger 1972; Christ et al. 1983; Olivera-Martinez et al. 2000; Nowicki et al. 2003), but remains distinct in postnatal animals despite the potential for extensive cell mixing (see Figure 8).
T11313	52477-52480	DT	denotes	The
T11314	52497-52505	NN	denotes	frontier
T11315	52481-52488	JJ	denotes	lateral
T11316	52489-52496	JJ	denotes	somitic
T11317	52604-52615	VBN	denotes	established
T11318	52505-52507	,	denotes	,
T11319	52507-52514	VBN	denotes	defined
T11320	52515-52517	IN	denotes	as
T11321	52518-52521	DT	denotes	the
T11322	52530-52538	NN	denotes	boundary
T11323	52522-52529	NN	denotes	lineage
T11324	52539-52546	IN	denotes	between
T11325	52547-52553	NN	denotes	somite
T11326	52554-52561	VBN	denotes	derived
T11327	52553-52554	HYPH	denotes	-
T11328	52591-52599	NN	denotes	mesoderm
T11329	52562-52568	CC	denotes	versus
T11330	52569-52576	JJ	denotes	lateral
T11331	52577-52582	NN	denotes	plate
T11332	52583-52590	VBN	denotes	derived
T11333	52582-52583	HYPH	denotes	-
T11334	52599-52601	,	denotes	,
T11335	52601-52603	VBZ	denotes	is
T11336	52616-52622	IN	denotes	during
T11337	52623-52636	NN	denotes	somitogenesis
T11338	52637-52642	RB	denotes	early
T11339	52643-52645	IN	denotes	in
T11340	52646-52657	NN	denotes	development
T11341	52658-52659	-LRB-	denotes	(
T11342	52659-52665	NNP	denotes	Mauger
T11343	52666-52670	CD	denotes	1972
T11344	52670-52671	:	denotes	;
T11345	52672-52678	NNP	denotes	Christ
T11346	52679-52681	FW	denotes	et
T11347	52682-52685	FW	denotes	al.
T11348	52686-52690	CD	denotes	1983
T11349	52690-52691	:	denotes	;
T11350	52692-52699	NNP	denotes	Olivera
T11351	52699-52700	HYPH	denotes	-
T11352	52700-52708	NNP	denotes	Martinez
T11353	52709-52711	FW	denotes	et
T11354	52712-52715	FW	denotes	al.
T11355	52716-52720	CD	denotes	2000
T11356	52720-52721	:	denotes	;
T11357	52722-52729	NNP	denotes	Nowicki
T11358	52730-52732	FW	denotes	et
T11359	52733-52736	FW	denotes	al.
T11360	52737-52741	CD	denotes	2003
T11361	52741-52742	-RRB-	denotes	)
T11362	52742-52744	,	denotes	,
T11363	52744-52747	CC	denotes	but
T11364	52748-52755	VBZ	denotes	remains
T11365	52756-52764	JJ	denotes	distinct
T11366	52765-52767	IN	denotes	in
T11367	52768-52777	JJ	denotes	postnatal
T11368	52778-52785	NNS	denotes	animals
T11369	52786-52793	IN	denotes	despite
T11370	52794-52797	DT	denotes	the
T11371	52798-52807	NN	denotes	potential
T11372	52808-52811	IN	denotes	for
T11373	52812-52821	JJ	denotes	extensive
T11374	52827-52833	NN	denotes	mixing
T11375	52822-52826	NN	denotes	cell
T11376	52834-52835	-LRB-	denotes	(
T11377	52835-52838	VB	denotes	see
T11378	52839-52845	NN	denotes	Figure
T11379	52846-52847	CD	denotes	8
T11380	52847-52848	-RRB-	denotes	)
T11381	52848-52849	.	denotes	.
T11382	52849-53061	sentence	denotes	However, our transplantation and fate-mapping studies demonstrate that the lateral somitic frontier lies dorsal to the pigmentation boundary and does not obviously correlate with a difference in skin morphology.
T11383	52850-52857	RB	denotes	However
T11384	52904-52915	VBP	denotes	demonstrate
T11385	52857-52859	,	denotes	,
T11386	52859-52862	PRP$	denotes	our
T11387	52896-52903	NNS	denotes	studies
T11388	52863-52878	NN	denotes	transplantation
T11389	52879-52882	CC	denotes	and
T11390	52883-52887	NN	denotes	fate
T11391	52887-52888	HYPH	denotes	-
T11392	52888-52895	VBG	denotes	mapping
T11393	52916-52920	IN	denotes	that
T11394	52950-52954	VBZ	denotes	lies
T11395	52921-52924	DT	denotes	the
T11396	52941-52949	NN	denotes	frontier
T11397	52925-52932	JJ	denotes	lateral
T11398	52933-52940	JJ	denotes	somitic
T11399	52955-52961	RB	denotes	dorsal
T11400	52962-52964	IN	denotes	to
T11401	52965-52968	DT	denotes	the
T11402	52982-52990	NN	denotes	boundary
T11403	52969-52981	NN	denotes	pigmentation
T11404	52991-52994	CC	denotes	and
T11405	52995-52999	VBZ	denotes	does
T11406	53014-53023	VB	denotes	correlate
T11407	53000-53003	RB	denotes	not
T11408	53004-53013	RB	denotes	obviously
T11409	53024-53028	IN	denotes	with
T11410	53029-53030	DT	denotes	a
T11411	53031-53041	NN	denotes	difference
T11412	53042-53044	IN	denotes	in
T11413	53045-53049	NN	denotes	skin
T11414	53050-53060	NN	denotes	morphology
T11415	53060-53061	.	denotes	.
T11416	53061-53331	sentence	denotes	An additional dorsoventral domain that is not externally apparent has emerged from studies of Msx1, whose expression marks a subgroup of somite-derived mesenchymal cells that contribute to dermis in a narrow stripe along the paraspinal region (Houzelstein et al. 2000).
T11417	53062-53064	DT	denotes	An
T11418	53089-53095	NN	denotes	domain
T11419	53065-53075	JJ	denotes	additional
T11420	53076-53088	JJ	denotes	dorsoventral
T11421	53132-53139	VBN	denotes	emerged
T11422	53096-53100	WDT	denotes	that
T11423	53101-53103	VBZ	denotes	is
T11424	53104-53107	RB	denotes	not
T11425	53108-53118	RB	denotes	externally
T11426	53119-53127	JJ	denotes	apparent
T11427	53128-53131	VBZ	denotes	has
T11428	53140-53144	IN	denotes	from
T11429	53145-53152	NNS	denotes	studies
T11430	53153-53155	IN	denotes	of
T11431	53156-53160	NN	denotes	Msx1
T11432	53160-53162	,	denotes	,
T11433	53162-53167	WP$	denotes	whose
T11434	53168-53178	NN	denotes	expression
T11435	53179-53184	VBZ	denotes	marks
T11436	53185-53186	DT	denotes	a
T11437	53187-53195	NN	denotes	subgroup
T11438	53196-53198	IN	denotes	of
T11439	53199-53205	NN	denotes	somite
T11440	53206-53213	VBN	denotes	derived
T11441	53205-53206	HYPH	denotes	-
T11442	53226-53231	NNS	denotes	cells
T11443	53214-53225	JJ	denotes	mesenchymal
T11444	53232-53236	WDT	denotes	that
T11445	53237-53247	VBP	denotes	contribute
T11446	53248-53250	IN	denotes	to
T11447	53251-53257	NN	denotes	dermis
T11448	53258-53260	IN	denotes	in
T11449	53261-53262	DT	denotes	a
T11450	53270-53276	NN	denotes	stripe
T11451	53263-53269	JJ	denotes	narrow
T11452	53277-53282	IN	denotes	along
T11453	53283-53286	DT	denotes	the
T11454	53298-53304	NN	denotes	region
T11455	53287-53297	JJ	denotes	paraspinal
T11456	53305-53306	-LRB-	denotes	(
T11457	53306-53317	NNP	denotes	Houzelstein
T11458	53318-53320	FW	denotes	et
T11459	53321-53324	FW	denotes	al.
T11460	53325-53329	CD	denotes	2000
T11461	53329-53330	-RRB-	denotes	)
T11462	53330-53331	.	denotes	.
T11463	53331-53570	sentence	denotes	Thus, there exist at least three distinct boundaries in postnatal mammalian skin that are parallel to the sagittal plane, marked by differences in pigment-type synthesis, differences in cell lineage, and differences in expression of Msx1.
T11464	53332-53336	RB	denotes	Thus
T11465	53344-53349	VBP	denotes	exist
T11466	53336-53338	,	denotes	,
T11467	53338-53343	EX	denotes	there
T11468	53350-53352	RB	denotes	at
T11469	53359-53364	CD	denotes	three
T11470	53353-53358	RBS	denotes	least
T11471	53374-53384	NNS	denotes	boundaries
T11472	53365-53373	JJ	denotes	distinct
T11473	53385-53387	IN	denotes	in
T11474	53388-53397	JJ	denotes	postnatal
T11475	53408-53412	NN	denotes	skin
T11476	53398-53407	JJ	denotes	mammalian
T11477	53413-53417	WDT	denotes	that
T11478	53418-53421	VBP	denotes	are
T11479	53422-53430	JJ	denotes	parallel
T11480	53431-53433	IN	denotes	to
T11481	53434-53437	DT	denotes	the
T11482	53447-53452	NN	denotes	plane
T11483	53438-53446	JJ	denotes	sagittal
T11484	53452-53454	,	denotes	,
T11485	53454-53460	VBN	denotes	marked
T11486	53461-53463	IN	denotes	by
T11487	53464-53475	NNS	denotes	differences
T11488	53476-53478	IN	denotes	in
T11489	53479-53486	NN	denotes	pigment
T11490	53487-53491	NN	denotes	type
T11491	53486-53487	HYPH	denotes	-
T11492	53492-53501	NN	denotes	synthesis
T11493	53501-53503	,	denotes	,
T11494	53503-53514	NNS	denotes	differences
T11495	53515-53517	IN	denotes	in
T11496	53518-53522	NN	denotes	cell
T11497	53523-53530	NN	denotes	lineage
T11498	53530-53532	,	denotes	,
T11499	53532-53535	CC	denotes	and
T11500	53536-53547	NNS	denotes	differences
T11501	53548-53550	IN	denotes	in
T11502	53551-53561	NN	denotes	expression
T11503	53562-53564	IN	denotes	of
T11504	53565-53569	NN	denotes	Msx1
T11505	53569-53570	.	denotes	.
T11506	53570-53758	sentence	denotes	In rodents, only the pigmentation boundary is evident externally, but many mammals have more complicated patterns of hair type, length, and/or color that vary along the dorsoventral axis.
T11507	53571-53573	IN	denotes	In
T11508	53614-53616	VBZ	denotes	is
T11509	53574-53581	NNS	denotes	rodents
T11510	53581-53583	,	denotes	,
T11511	53583-53587	RB	denotes	only
T11512	53605-53613	NN	denotes	boundary
T11513	53588-53591	DT	denotes	the
T11514	53592-53604	NN	denotes	pigmentation
T11515	53617-53624	JJ	denotes	evident
T11516	53625-53635	RB	denotes	externally
T11517	53635-53637	,	denotes	,
T11518	53637-53640	CC	denotes	but
T11519	53641-53645	JJ	denotes	many
T11520	53646-53653	NNS	denotes	mammals
T11521	53654-53658	VBP	denotes	have
T11522	53659-53663	RBR	denotes	more
T11523	53664-53675	JJ	denotes	complicated
T11524	53676-53684	NNS	denotes	patterns
T11525	53685-53687	IN	denotes	of
T11526	53688-53692	NN	denotes	hair
T11527	53693-53697	NN	denotes	type
T11528	53697-53699	,	denotes	,
T11529	53699-53705	NN	denotes	length
T11530	53705-53707	,	denotes	,
T11531	53707-53710	CC	denotes	and
T11532	53710-53711	HYPH	denotes	/
T11533	53711-53713	CC	denotes	or
T11534	53714-53719	NN	denotes	color
T11535	53720-53724	WDT	denotes	that
T11536	53725-53729	VBP	denotes	vary
T11537	53730-53735	IN	denotes	along
T11538	53736-53739	DT	denotes	the
T11539	53753-53757	NN	denotes	axis
T11540	53740-53752	JJ	denotes	dorsoventral
T11541	53757-53758	.	denotes	.
T11542	53758-54022	sentence	denotes	Raccoons, squirrels, skunks, and many different ungulates exhibit lateral stripes whose developmental origins have not been investigated, but may correspond to the lateral somitic frontier, the paraspinal Msx1 compartment, or an interaction between these domains.
T11543	53759-53767	NNS	denotes	Raccoons
T11544	53817-53824	VBP	denotes	exhibit
T11545	53767-53769	,	denotes	,
T11546	53769-53778	NNS	denotes	squirrels
T11547	53778-53780	,	denotes	,
T11548	53780-53786	NNS	denotes	skunks
T11549	53786-53788	,	denotes	,
T11550	53788-53791	CC	denotes	and
T11551	53792-53796	JJ	denotes	many
T11552	53807-53816	NNS	denotes	ungulates
T11553	53797-53806	JJ	denotes	different
T11554	53825-53832	JJ	denotes	lateral
T11555	53833-53840	NNS	denotes	stripes
T11556	53841-53846	WP$	denotes	whose
T11557	53861-53868	NNS	denotes	origins
T11558	53847-53860	JJ	denotes	developmental
T11559	53883-53895	VBN	denotes	investigated
T11560	53869-53873	VBP	denotes	have
T11561	53874-53877	RB	denotes	not
T11562	53878-53882	VBN	denotes	been
T11563	53895-53897	,	denotes	,
T11564	53897-53900	CC	denotes	but
T11565	53901-53904	MD	denotes	may
T11566	53905-53915	VB	denotes	correspond
T11567	53916-53918	IN	denotes	to
T11568	53919-53922	DT	denotes	the
T11569	53939-53947	NN	denotes	frontier
T11570	53923-53930	JJ	denotes	lateral
T11571	53931-53938	JJ	denotes	somitic
T11572	53947-53949	,	denotes	,
T11573	53949-53952	DT	denotes	the
T11574	53969-53980	NN	denotes	compartment
T11575	53953-53963	JJ	denotes	paraspinal
T11576	53964-53968	NN	denotes	Msx1
T11577	53980-53982	,	denotes	,
T11578	53982-53984	CC	denotes	or
T11579	53985-53987	DT	denotes	an
T11580	53988-53999	NN	denotes	interaction
T11581	54000-54007	IN	denotes	between
T11582	54008-54013	DT	denotes	these
T11583	54014-54021	NNS	denotes	domains
T11584	54021-54022	.	denotes	.
T11585	54022-54174	sentence	denotes	The effect of Tbx15 on pigmentation in laboratory mice is reminiscent of coat-color patterns in both selected and natural populations of other mammals.
T11586	54023-54026	DT	denotes	The
T11587	54027-54033	NN	denotes	effect
T11588	54078-54080	VBZ	denotes	is
T11589	54034-54036	IN	denotes	of
T11590	54037-54042	NN	denotes	Tbx15
T11591	54043-54045	IN	denotes	on
T11592	54046-54058	NN	denotes	pigmentation
T11593	54059-54061	IN	denotes	in
T11594	54062-54072	NN	denotes	laboratory
T11595	54073-54077	NNS	denotes	mice
T11596	54081-54092	JJ	denotes	reminiscent
T11597	54093-54095	IN	denotes	of
T11598	54096-54100	NN	denotes	coat
T11599	54101-54106	NN	denotes	color
T11600	54100-54101	HYPH	denotes	-
T11601	54107-54115	NNS	denotes	patterns
T11602	54116-54118	IN	denotes	in
T11603	54119-54123	CC	denotes	both
T11604	54124-54132	JJ	denotes	selected
T11605	54145-54156	NNS	denotes	populations
T11606	54133-54136	CC	denotes	and
T11607	54137-54144	JJ	denotes	natural
T11608	54157-54159	IN	denotes	of
T11609	54160-54165	JJ	denotes	other
T11610	54166-54173	NNS	denotes	mammals
T11611	54173-54174	.	denotes	.
T11612	54174-54478	sentence	denotes	Saddle markings are common in some dog breeds, such as German shepherds, and in certain populations of Peromyscus polionotus, in which a dorsal extension of ventral depigmentation provides an adaptive advantage to subspecies that live on white sand reefs (Blair 1951; Kaufman 1974; Belk and Smith 1996).
T11613	54175-54181	NN	denotes	Saddle
T11614	54182-54190	NNS	denotes	markings
T11615	54191-54194	VBP	denotes	are
T11616	54195-54201	JJ	denotes	common
T11617	54202-54204	IN	denotes	in
T11618	54205-54209	DT	denotes	some
T11619	54214-54220	NNS	denotes	breeds
T11620	54210-54213	NN	denotes	dog
T11621	54220-54222	,	denotes	,
T11622	54222-54226	JJ	denotes	such
T11623	54227-54229	IN	denotes	as
T11624	54230-54236	NNP	denotes	German
T11625	54237-54246	NNS	denotes	shepherds
T11626	54246-54248	,	denotes	,
T11627	54248-54251	CC	denotes	and
T11628	54252-54254	IN	denotes	in
T11629	54255-54262	JJ	denotes	certain
T11630	54263-54274	NNS	denotes	populations
T11631	54275-54277	IN	denotes	of
T11632	54278-54288	NNP	denotes	Peromyscus
T11633	54289-54299	NNP	denotes	polionotus
T11634	54299-54301	,	denotes	,
T11635	54301-54303	IN	denotes	in
T11636	54355-54363	VBZ	denotes	provides
T11637	54304-54309	WDT	denotes	which
T11638	54310-54311	DT	denotes	a
T11639	54319-54328	NN	denotes	extension
T11640	54312-54318	JJ	denotes	dorsal
T11641	54329-54331	IN	denotes	of
T11642	54332-54339	JJ	denotes	ventral
T11643	54340-54354	NN	denotes	depigmentation
T11644	54364-54366	DT	denotes	an
T11645	54376-54385	NN	denotes	advantage
T11646	54367-54375	JJ	denotes	adaptive
T11647	54386-54388	IN	denotes	to
T11648	54389-54399	NNS	denotes	subspecies
T11649	54400-54404	WDT	denotes	that
T11650	54405-54409	VBP	denotes	live
T11651	54410-54412	IN	denotes	on
T11652	54413-54418	JJ	denotes	white
T11653	54424-54429	NNS	denotes	reefs
T11654	54419-54423	NN	denotes	sand
T11655	54430-54431	-LRB-	denotes	(
T11656	54431-54436	NNP	denotes	Blair
T11657	54437-54441	CD	denotes	1951
T11658	54441-54442	:	denotes	;
T11659	54443-54450	NNP	denotes	Kaufman
T11660	54451-54455	CD	denotes	1974
T11661	54455-54456	:	denotes	;
T11662	54457-54461	NNP	denotes	Belk
T11663	54462-54465	CC	denotes	and
T11664	54466-54471	NNP	denotes	Smith
T11665	54472-54476	CD	denotes	1996
T11666	54476-54477	-RRB-	denotes	)
T11667	54477-54478	.	denotes	.
T11668	54478-54702	sentence	denotes	Neither German shepherds nor deer mice have craniofacial characteristics similar to the deH mutation, but the pigmentation patterns in these animals could represent alterations in the regulation or action of Tbx15 activity.
T11669	54479-54486	CC	denotes	Neither
T11670	54494-54503	NNS	denotes	shepherds
T11671	54487-54493	NNP	denotes	German
T11672	54518-54522	VBP	denotes	have
T11673	54504-54507	CC	denotes	nor
T11674	54508-54512	NN	denotes	deer
T11675	54513-54517	NNS	denotes	mice
T11676	54523-54535	JJ	denotes	craniofacial
T11677	54536-54551	NNS	denotes	characteristics
T11678	54552-54559	JJ	denotes	similar
T11679	54560-54562	IN	denotes	to
T11680	54563-54566	DT	denotes	the
T11681	54571-54579	NN	denotes	mutation
T11682	54567-54570	NN	denotes	deH
T11683	54579-54581	,	denotes	,
T11684	54581-54584	CC	denotes	but
T11685	54585-54588	DT	denotes	the
T11686	54602-54610	NNS	denotes	patterns
T11687	54589-54601	NN	denotes	pigmentation
T11688	54634-54643	VB	denotes	represent
T11689	54611-54613	IN	denotes	in
T11690	54614-54619	DT	denotes	these
T11691	54620-54627	NNS	denotes	animals
T11692	54628-54633	MD	denotes	could
T11693	54644-54655	NNS	denotes	alterations
T11694	54656-54658	IN	denotes	in
T11695	54659-54662	DT	denotes	the
T11696	54663-54673	NN	denotes	regulation
T11697	54674-54676	CC	denotes	or
T11698	54677-54683	NN	denotes	action
T11699	54684-54686	IN	denotes	of
T11700	54687-54692	NN	denotes	Tbx15
T11701	54693-54701	NN	denotes	activity
T11702	54701-54702	.	denotes	.
T11703	54702-54904	sentence	denotes	From the opposite perspective, the effects of Tbx15 on coat color are only apparent in certain genetic backgrounds and may not be evident at all in mammals that lack dorsoventral pigmentation patterns.
T11704	54703-54707	IN	denotes	From
T11705	54769-54772	VBP	denotes	are
T11706	54708-54711	DT	denotes	the
T11707	54721-54732	NN	denotes	perspective
T11708	54712-54720	JJ	denotes	opposite
T11709	54732-54734	,	denotes	,
T11710	54734-54737	DT	denotes	the
T11711	54738-54745	NNS	denotes	effects
T11712	54746-54748	IN	denotes	of
T11713	54749-54754	NN	denotes	Tbx15
T11714	54755-54757	IN	denotes	on
T11715	54758-54762	NN	denotes	coat
T11716	54763-54768	NN	denotes	color
T11717	54773-54777	RB	denotes	only
T11718	54778-54786	JJ	denotes	apparent
T11719	54787-54789	IN	denotes	in
T11720	54790-54797	JJ	denotes	certain
T11721	54806-54817	NNS	denotes	backgrounds
T11722	54798-54805	JJ	denotes	genetic
T11723	54818-54821	CC	denotes	and
T11724	54822-54825	MD	denotes	may
T11725	54830-54832	VB	denotes	be
T11726	54826-54829	RB	denotes	not
T11727	54833-54840	JJ	denotes	evident
T11728	54841-54843	RB	denotes	at
T11729	54844-54847	RB	denotes	all
T11730	54848-54850	IN	denotes	in
T11731	54851-54858	NNS	denotes	mammals
T11732	54859-54863	WDT	denotes	that
T11733	54864-54868	VBP	denotes	lack
T11734	54869-54881	JJ	denotes	dorsoventral
T11735	54895-54903	NNS	denotes	patterns
T11736	54882-54894	NN	denotes	pigmentation
T11737	54903-54904	.	denotes	.
T11738	54904-55075	sentence	denotes	Studying the sequence and expression of Tbx15 in other vertebrates may provide additional insight into patterns that affect the skeleton as well as the pigmentary system.
T11739	54905-54913	VBG	denotes	Studying
T11740	54976-54983	VB	denotes	provide
T11741	54914-54917	DT	denotes	the
T11742	54918-54926	NN	denotes	sequence
T11743	54927-54930	CC	denotes	and
T11744	54931-54941	NN	denotes	expression
T11745	54942-54944	IN	denotes	of
T11746	54945-54950	NN	denotes	Tbx15
T11747	54951-54953	IN	denotes	in
T11748	54954-54959	JJ	denotes	other
T11749	54960-54971	NNS	denotes	vertebrates
T11750	54972-54975	MD	denotes	may
T11751	54984-54994	JJ	denotes	additional
T11752	54995-55002	NN	denotes	insight
T11753	55003-55007	IN	denotes	into
T11754	55008-55016	NNS	denotes	patterns
T11755	55017-55021	WDT	denotes	that
T11756	55022-55028	VBP	denotes	affect
T11757	55029-55032	DT	denotes	the
T11758	55033-55041	NN	denotes	skeleton
T11759	55042-55044	RB	denotes	as
T11760	55050-55052	IN	denotes	as
T11761	55045-55049	RB	denotes	well
T11762	55053-55056	DT	denotes	the
T11763	55068-55074	NN	denotes	system
T11764	55057-55067	JJ	denotes	pigmentary
T11765	55074-55075	.	denotes	.
T11800	55104-55714	sentence	denotes	All mice were obtained originally from The Jackson Laboratory (Bar Harbor, Maine, United States), except the BA strain (Stanford Veterinary Services Center, Stanford, California, United States), Hoxb6-Cre transgenic mice (kindly provided by M. Kuehn of the National Institutes of Health, Bethesda, Maryland, United States), mice carrying the R26R lacZ reporter allele (kindly provided by P. Soriano, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States), and C57BL/6J (B6) ae/ae mice (kindly provided by L. Siracusa, Jefferson Medical College, Philadelphia, Pennsylvania, United States).
T11801	55105-55108	DT	denotes	All
T11802	55109-55113	NNS	denotes	mice
T11803	55119-55127	VBN	denotes	obtained
T11804	55114-55118	VBD	denotes	were
T11805	55128-55138	RB	denotes	originally
T11806	55139-55143	IN	denotes	from
T11807	55144-55147	DT	denotes	The
T11808	55156-55166	NNP	denotes	Laboratory
T11809	55148-55155	NNP	denotes	Jackson
T11810	55167-55168	-LRB-	denotes	(
T11811	55172-55178	NNP	denotes	Harbor
T11812	55168-55171	NNP	denotes	Bar
T11813	55178-55180	,	denotes	,
T11814	55180-55185	NNP	denotes	Maine
T11815	55185-55187	,	denotes	,
T11816	55187-55193	NNP	denotes	United
T11817	55194-55200	NNP	denotes	States
T11818	55200-55201	-RRB-	denotes	)
T11819	55201-55203	,	denotes	,
T11820	55203-55209	IN	denotes	except
T11821	55210-55213	DT	denotes	the
T11822	55217-55223	NN	denotes	strain
T11823	55214-55216	NN	denotes	BA
T11824	55224-55225	-LRB-	denotes	(
T11825	55254-55260	NNP	denotes	Center
T11826	55225-55233	NNP	denotes	Stanford
T11827	55234-55244	NNP	denotes	Veterinary
T11828	55245-55253	NNPS	denotes	Services
T11829	55260-55262	,	denotes	,
T11830	55262-55270	NNP	denotes	Stanford
T11831	55270-55272	,	denotes	,
T11832	55272-55282	NNP	denotes	California
T11833	55282-55284	,	denotes	,
T11834	55284-55290	NNP	denotes	United
T11835	55291-55297	NNP	denotes	States
T11836	55297-55298	-RRB-	denotes	)
T11837	55298-55300	,	denotes	,
T11838	55300-55305	NN	denotes	Hoxb6
T11839	55306-55309	NN	denotes	Cre
T11840	55305-55306	HYPH	denotes	-
T11841	55321-55325	NNS	denotes	mice
T11842	55310-55320	JJ	denotes	transgenic
T11843	55326-55327	-LRB-	denotes	(
T11844	55327-55333	RB	denotes	kindly
T11845	55334-55342	VBN	denotes	provided
T11846	55343-55345	IN	denotes	by
T11847	55346-55348	NNP	denotes	M.
T11848	55349-55354	NNP	denotes	Kuehn
T11849	55355-55357	IN	denotes	of
T11850	55358-55361	DT	denotes	the
T11851	55371-55381	NNPS	denotes	Institutes
T11852	55362-55370	NNP	denotes	National
T11853	55382-55384	IN	denotes	of
T11854	55385-55391	NNP	denotes	Health
T11855	55391-55393	,	denotes	,
T11856	55393-55401	NNP	denotes	Bethesda
T11857	55401-55403	,	denotes	,
T11858	55403-55411	NNP	denotes	Maryland
T11859	55411-55413	,	denotes	,
T11860	55413-55419	NNP	denotes	United
T11861	55420-55426	NNP	denotes	States
T11862	55426-55427	-RRB-	denotes	)
T11863	55427-55429	,	denotes	,
T11864	55429-55433	NNS	denotes	mice
T11865	55434-55442	VBG	denotes	carrying
T11866	55443-55446	DT	denotes	the
T11867	55466-55472	NN	denotes	allele
T11868	55447-55451	NN	denotes	R26R
T11869	55457-55465	NN	denotes	reporter
T11870	55452-55456	NN	denotes	lacZ
T11871	55473-55474	-LRB-	denotes	(
T11872	55474-55480	RB	denotes	kindly
T11873	55481-55489	VBN	denotes	provided
T11874	55490-55492	IN	denotes	by
T11875	55493-55495	NNP	denotes	P.
T11876	55496-55503	NNP	denotes	Soriano
T11877	55503-55505	,	denotes	,
T11878	55505-55509	NNP	denotes	Fred
T11879	55537-55543	NNP	denotes	Center
T11880	55510-55520	NNP	denotes	Hutchinson
T11881	55521-55527	NNP	denotes	Cancer
T11882	55528-55536	NNP	denotes	Research
T11883	55543-55545	,	denotes	,
T11884	55545-55552	NNP	denotes	Seattle
T11885	55552-55554	,	denotes	,
T11886	55554-55564	NNP	denotes	Washington
T11887	55564-55566	,	denotes	,
T11888	55566-55572	NNP	denotes	United
T11889	55573-55579	NNP	denotes	States
T11890	55579-55580	-RRB-	denotes	)
T11891	55580-55582	,	denotes	,
T11892	55582-55585	CC	denotes	and
T11893	55586-55591	NN	denotes	C57BL
T11894	55592-55594	NN	denotes	6J
T11895	55591-55592	HYPH	denotes	/
T11896	55606-55610	NNS	denotes	mice
T11897	55595-55596	-LRB-	denotes	(
T11898	55596-55598	NN	denotes	B6
T11899	55598-55599	-RRB-	denotes	)
T11900	55600-55602	NN	denotes	ae
T11901	55603-55605	NN	denotes	ae
T11902	55602-55603	HYPH	denotes	/
T11903	55611-55612	-LRB-	denotes	(
T11904	55612-55618	RB	denotes	kindly
T11905	55619-55627	VBN	denotes	provided
T11906	55628-55630	IN	denotes	by
T11907	55631-55633	NNP	denotes	L.
T11908	55634-55642	NNP	denotes	Siracusa
T11909	55642-55644	,	denotes	,
T11910	55644-55653	NNP	denotes	Jefferson
T11911	55662-55669	NNP	denotes	College
T11912	55654-55661	NNP	denotes	Medical
T11913	55669-55671	,	denotes	,
T11914	55671-55683	NNP	denotes	Philadelphia
T11915	55683-55685	,	denotes	,
T11916	55685-55697	NNP	denotes	Pennsylvania
T11917	55697-55699	,	denotes	,
T11918	55699-55705	NNP	denotes	United
T11919	55706-55712	NNP	denotes	States
T11920	55712-55713	-RRB-	denotes	)
T11921	55713-55714	.	denotes	.
T11922	55714-55837	sentence	denotes	The deH mutation arose in the 1960s in Harwell, probably on the BN strain background (C. Beechey, personal communication).
T11923	55715-55718	DT	denotes	The
T11924	55723-55731	NN	denotes	mutation
T11925	55719-55722	NN	denotes	deH
T11926	55732-55737	VBD	denotes	arose
T11927	55738-55740	IN	denotes	in
T11928	55741-55744	DT	denotes	the
T11929	55745-55750	NNS	denotes	1960s
T11930	55751-55753	IN	denotes	in
T11931	55754-55761	NNP	denotes	Harwell
T11932	55761-55763	,	denotes	,
T11933	55763-55771	RB	denotes	probably
T11934	55772-55774	IN	denotes	on
T11935	55775-55778	DT	denotes	the
T11936	55789-55799	NN	denotes	background
T11937	55779-55781	NN	denotes	BN
T11938	55782-55788	NN	denotes	strain
T11939	55800-55801	-LRB-	denotes	(
T11940	55801-55803	NNP	denotes	C.
T11941	55804-55811	NNP	denotes	Beechey
T11942	55811-55813	,	denotes	,
T11943	55813-55821	JJ	denotes	personal
T11944	55822-55835	NN	denotes	communication
T11945	55835-55836	-RRB-	denotes	)
T11946	55836-55837	.	denotes	.
T11947	55837-56038	sentence	denotes	We obtained deH on a B6/EiC3H background, introduced the at allele from the BTBR strain, and have maintained the line as a mixed deH/+ × deH/+ intercross stock with periodic outcrossing to BTBR or B6.
T11948	55838-55840	PRP	denotes	We
T11949	55841-55849	VBD	denotes	obtained
T11950	55850-55853	NN	denotes	deH
T11951	55854-55856	IN	denotes	on
T11952	55857-55858	DT	denotes	a
T11953	55868-55878	NN	denotes	background
T11954	55859-55861	NN	denotes	B6
T11955	55862-55867	NN	denotes	EiC3H
T11956	55861-55862	HYPH	denotes	/
T11957	55878-55880	,	denotes	,
T11958	55880-55890	VBD	denotes	introduced
T11959	55891-55894	DT	denotes	the
T11960	55898-55904	NN	denotes	allele
T11961	55895-55897	NN	denotes	at
T11962	55905-55909	IN	denotes	from
T11963	55910-55913	DT	denotes	the
T11964	55919-55925	NN	denotes	strain
T11965	55914-55918	NN	denotes	BTBR
T11966	55925-55927	,	denotes	,
T11967	55927-55930	CC	denotes	and
T11968	55931-55935	VBP	denotes	have
T11969	55936-55946	VBN	denotes	maintained
T11970	55947-55950	DT	denotes	the
T11971	55951-55955	NN	denotes	line
T11972	55956-55958	IN	denotes	as
T11973	55959-55960	DT	denotes	a
T11974	55992-55997	NN	denotes	stock
T11975	55961-55966	VBN	denotes	mixed
T11976	55967-55970	NN	denotes	deH
T11977	55970-55971	HYPH	denotes	/
T11978	55971-55972	SYM	denotes	+
T11979	55973-55974	SYM	denotes	×
T11980	55975-55978	NN	denotes	deH
T11981	55978-55979	HYPH	denotes	/
T11982	55979-55980	SYM	denotes	+
T11983	55981-55991	JJ	denotes	intercross
T11984	55998-56002	IN	denotes	with
T11985	56003-56011	JJ	denotes	periodic
T11986	56012-56023	NN	denotes	outcrossing
T11987	56024-56026	IN	denotes	to
T11988	56027-56031	NN	denotes	BTBR
T11989	56032-56034	CC	denotes	or
T11990	56035-56037	NN	denotes	B6
T11991	56037-56038	.	denotes	.
T11992	56038-56102	sentence	denotes	For timed matings, the morning of the plug was considered E0.5.
T11993	56039-56042	IN	denotes	For
T11994	56086-56096	VBN	denotes	considered
T11995	56043-56048	VBN	denotes	timed
T11996	56049-56056	NNS	denotes	matings
T11997	56056-56058	,	denotes	,
T11998	56058-56061	DT	denotes	the
T11999	56062-56069	NN	denotes	morning
T12000	56070-56072	IN	denotes	of
T12001	56073-56076	DT	denotes	the
T12002	56077-56081	NN	denotes	plug
T12003	56082-56085	VBD	denotes	was
T12004	56097-56101	NN	denotes	E0.5
T12005	56101-56102	.	denotes	.
T12006	56102-56159	sentence	denotes	Postnatally, the day of birth was considered to be P0.5.
T12007	56103-56114	RB	denotes	Postnatally
T12008	56137-56147	VBN	denotes	considered
T12009	56114-56116	,	denotes	,
T12010	56116-56119	DT	denotes	the
T12011	56120-56123	NN	denotes	day
T12012	56124-56126	IN	denotes	of
T12013	56127-56132	NN	denotes	birth
T12014	56133-56136	VBD	denotes	was
T12015	56148-56150	TO	denotes	to
T12016	56151-56153	VB	denotes	be
T12017	56154-56158	NN	denotes	P0.5
T12018	56158-56159	.	denotes	.
T12097	56161-56171	JJ	denotes	Phenotypic
T12098	56172-56180	NN	denotes	analysis
T12099	56180-56372	sentence	denotes	For measurements of hair length and color, the entire interlimb region of skin was first dissected with a single incision at the dorsal midline and preserved with powdered sodium bicarbonate.
T12100	56181-56184	IN	denotes	For
T12101	56270-56279	VBN	denotes	dissected
T12102	56185-56197	NNS	denotes	measurements
T12103	56198-56200	IN	denotes	of
T12104	56201-56205	NN	denotes	hair
T12105	56206-56212	NN	denotes	length
T12106	56213-56216	CC	denotes	and
T12107	56217-56222	NN	denotes	color
T12108	56222-56224	,	denotes	,
T12109	56224-56227	DT	denotes	the
T12110	56245-56251	NN	denotes	region
T12111	56228-56234	JJ	denotes	entire
T12112	56235-56244	NN	denotes	interlimb
T12113	56252-56254	IN	denotes	of
T12114	56255-56259	NN	denotes	skin
T12115	56260-56263	VBD	denotes	was
T12116	56264-56269	RB	denotes	first
T12117	56280-56284	IN	denotes	with
T12118	56285-56286	DT	denotes	a
T12119	56294-56302	NN	denotes	incision
T12120	56287-56293	JJ	denotes	single
T12121	56303-56305	IN	denotes	at
T12122	56306-56309	DT	denotes	the
T12123	56317-56324	NN	denotes	midline
T12124	56310-56316	JJ	denotes	dorsal
T12125	56325-56328	CC	denotes	and
T12126	56329-56338	VBN	denotes	preserved
T12127	56339-56343	IN	denotes	with
T12128	56344-56352	VBN	denotes	powdered
T12129	56360-56371	NN	denotes	bicarbonate
T12130	56353-56359	NN	denotes	sodium
T12131	56371-56372	.	denotes	.
T12132	56372-56640	sentence	denotes	Slices 2–2.5 mm in width were then prepared parallel to the dorsoventral axis, hair length boundaries determined from electronic images with Adobe Photoshop (San Jose, California, United States), and measurements obtained using ImageJ (National Institutes of Health).
T12133	56373-56379	NNS	denotes	Slices
T12134	56408-56416	VBN	denotes	prepared
T12135	56380-56381	CD	denotes	2
T12136	56382-56385	CD	denotes	2.5
T12137	56381-56382	HYPH	denotes	–
T12138	56386-56388	NN	denotes	mm
T12139	56389-56391	IN	denotes	in
T12140	56392-56397	NN	denotes	width
T12141	56398-56402	VBD	denotes	were
T12142	56403-56407	RB	denotes	then
T12143	56417-56425	RB	denotes	parallel
T12144	56426-56428	IN	denotes	to
T12145	56429-56432	DT	denotes	the
T12146	56446-56450	NN	denotes	axis
T12147	56433-56445	JJ	denotes	dorsoventral
T12148	56450-56452	,	denotes	,
T12149	56452-56456	NN	denotes	hair
T12150	56464-56474	NNS	denotes	boundaries
T12151	56457-56463	NN	denotes	length
T12152	56475-56485	VBN	denotes	determined
T12153	56486-56490	IN	denotes	from
T12154	56491-56501	JJ	denotes	electronic
T12155	56502-56508	NNS	denotes	images
T12156	56509-56513	IN	denotes	with
T12157	56514-56519	NNP	denotes	Adobe
T12158	56520-56529	NNP	denotes	Photoshop
T12159	56530-56531	-LRB-	denotes	(
T12160	56535-56539	NNP	denotes	Jose
T12161	56531-56534	NNP	denotes	San
T12162	56539-56541	,	denotes	,
T12163	56541-56551	NNP	denotes	California
T12164	56551-56553	,	denotes	,
T12165	56553-56559	NNP	denotes	United
T12166	56560-56566	NNP	denotes	States
T12167	56566-56567	-RRB-	denotes	)
T12168	56567-56569	,	denotes	,
T12169	56569-56572	CC	denotes	and
T12170	56573-56585	NNS	denotes	measurements
T12171	56586-56594	VBN	denotes	obtained
T12172	56595-56600	VBG	denotes	using
T12173	56601-56607	NNP	denotes	ImageJ
T12174	56608-56609	-LRB-	denotes	(
T12175	56618-56628	NNPS	denotes	Institutes
T12176	56609-56617	NNP	denotes	National
T12177	56629-56631	IN	denotes	of
T12178	56632-56638	NNP	denotes	Health
T12179	56638-56639	-RRB-	denotes	)
T12180	56639-56640	.	denotes	.
T12181	56640-56775	sentence	denotes	This approach samples awls and auchenes, because they are much thicker and therefore visually more predominant than zigzag underhairs.
T12182	56641-56645	DT	denotes	This
T12183	56646-56654	NN	denotes	approach
T12184	56655-56662	VBZ	denotes	samples
T12185	56663-56667	NNS	denotes	awls
T12186	56668-56671	CC	denotes	and
T12187	56672-56680	NNS	denotes	auchenes
T12188	56680-56682	,	denotes	,
T12189	56682-56689	IN	denotes	because
T12190	56695-56698	VBP	denotes	are
T12191	56690-56694	PRP	denotes	they
T12192	56699-56703	RB	denotes	much
T12193	56704-56711	JJR	denotes	thicker
T12194	56712-56715	CC	denotes	and
T12195	56716-56725	RB	denotes	therefore
T12196	56740-56751	JJ	denotes	predominant
T12197	56726-56734	RB	denotes	visually
T12198	56735-56739	RBR	denotes	more
T12199	56752-56756	IN	denotes	than
T12200	56757-56763	NN	denotes	zigzag
T12201	56764-56774	NNS	denotes	underhairs
T12202	56774-56775	.	denotes	.
T12203	56775-56998	sentence	denotes	To assess dorsoventral variation in hair-type distribution, several hundred hairs were plucked from the middorsum or midventrum of 8-wk-old male BA strain animals, then sorted and categorized using a dissection microscope.
T12204	56776-56778	TO	denotes	To
T12205	56779-56785	VB	denotes	assess
T12206	56863-56870	VBN	denotes	plucked
T12207	56786-56798	JJ	denotes	dorsoventral
T12208	56799-56808	NN	denotes	variation
T12209	56809-56811	IN	denotes	in
T12210	56812-56816	NN	denotes	hair
T12211	56817-56821	NN	denotes	type
T12212	56816-56817	HYPH	denotes	-
T12213	56822-56834	NN	denotes	distribution
T12214	56834-56836	,	denotes	,
T12215	56836-56843	JJ	denotes	several
T12216	56852-56857	NNS	denotes	hairs
T12217	56844-56851	CD	denotes	hundred
T12218	56858-56862	VBD	denotes	were
T12219	56871-56875	IN	denotes	from
T12220	56876-56879	DT	denotes	the
T12221	56880-56889	NN	denotes	middorsum
T12222	56890-56892	CC	denotes	or
T12223	56893-56903	NN	denotes	midventrum
T12224	56904-56906	IN	denotes	of
T12225	56907-56908	CD	denotes	8
T12226	56909-56911	NN	denotes	wk
T12227	56908-56909	HYPH	denotes	-
T12228	56912-56915	JJ	denotes	old
T12229	56911-56912	HYPH	denotes	-
T12230	56931-56938	NNS	denotes	animals
T12231	56916-56920	JJ	denotes	male
T12232	56921-56923	NN	denotes	BA
T12233	56924-56930	NN	denotes	strain
T12234	56938-56940	,	denotes	,
T12235	56940-56944	RB	denotes	then
T12236	56945-56951	VBN	denotes	sorted
T12237	56952-56955	CC	denotes	and
T12238	56956-56967	VBN	denotes	categorized
T12239	56968-56973	VBG	denotes	using
T12240	56974-56975	DT	denotes	a
T12241	56987-56997	NN	denotes	microscope
T12242	56976-56986	NN	denotes	dissection
T12243	56997-56998	.	denotes	.
T12244	56998-57060	sentence	denotes	No attempt was made to distinguish between awls and auchenes.
T12245	56999-57001	DT	denotes	No
T12246	57002-57009	NN	denotes	attempt
T12247	57014-57018	VBN	denotes	made
T12248	57010-57013	VBD	denotes	was
T12249	57019-57021	TO	denotes	to
T12250	57022-57033	VB	denotes	distinguish
T12251	57034-57041	IN	denotes	between
T12252	57042-57046	NNS	denotes	awls
T12253	57047-57050	CC	denotes	and
T12254	57051-57059	NNS	denotes	auchenes
T12255	57059-57060	.	denotes	.
T12256	57060-57166	sentence	denotes	For skin histology, 12 μm sections from paraffin-embedded tissue were stained with hematoxylin and eosin.
T12257	57061-57064	IN	denotes	For
T12258	57131-57138	VBN	denotes	stained
T12259	57065-57069	NN	denotes	skin
T12260	57070-57079	NN	denotes	histology
T12261	57079-57081	,	denotes	,
T12262	57081-57083	CD	denotes	12
T12263	57084-57086	NN	denotes	μm
T12264	57087-57095	NNS	denotes	sections
T12265	57096-57100	IN	denotes	from
T12266	57101-57109	NN	denotes	paraffin
T12267	57110-57118	VBN	denotes	embedded
T12268	57109-57110	HYPH	denotes	-
T12269	57119-57125	NN	denotes	tissue
T12270	57126-57130	VBD	denotes	were
T12271	57139-57143	IN	denotes	with
T12272	57144-57155	NN	denotes	hematoxylin
T12273	57156-57159	CC	denotes	and
T12274	57160-57165	NN	denotes	eosin
T12275	57165-57166	.	denotes	.
T12276	57166-57572	sentence	denotes	For DOPA staining, the dermis and epidermis were split after 3 h of incubation in 2 M sodium bromide at 37°C (this preparation causes most hair follicles to remain with the dermis), individually fixed for 1 h, then rinsed and stained with 0.1% L-DOPA (Sigma, St. Louis, Missouri, United States), 0.1 M sodium phosphate buffer (pH 6.8) for 5 h at 37°C in the dark, changing the staining solution after 1 h.
T12277	57167-57170	IN	denotes	For
T12278	57216-57221	VBN	denotes	split
T12279	57171-57175	NN	denotes	DOPA
T12280	57176-57184	NN	denotes	staining
T12281	57184-57186	,	denotes	,
T12282	57186-57189	DT	denotes	the
T12283	57190-57196	NN	denotes	dermis
T12284	57197-57200	CC	denotes	and
T12285	57201-57210	NN	denotes	epidermis
T12286	57211-57215	VBD	denotes	were
T12287	57222-57227	IN	denotes	after
T12288	57228-57229	CD	denotes	3
T12289	57230-57231	NN	denotes	h
T12290	57232-57234	IN	denotes	of
T12291	57235-57245	NN	denotes	incubation
T12292	57246-57248	IN	denotes	in
T12293	57249-57250	CD	denotes	2
T12294	57251-57252	NN	denotes	M
T12295	57260-57267	NN	denotes	bromide
T12296	57253-57259	NN	denotes	sodium
T12297	57268-57270	IN	denotes	at
T12298	57271-57273	CD	denotes	37
T12299	57273-57275	NN	denotes	°C
T12300	57276-57277	-LRB-	denotes	(
T12301	57294-57300	VBZ	denotes	causes
T12302	57277-57281	DT	denotes	this
T12303	57282-57293	NN	denotes	preparation
T12304	57301-57305	JJS	denotes	most
T12305	57311-57320	NNS	denotes	follicles
T12306	57306-57310	NN	denotes	hair
T12307	57324-57330	VB	denotes	remain
T12308	57321-57323	TO	denotes	to
T12309	57331-57335	IN	denotes	with
T12310	57336-57339	DT	denotes	the
T12311	57340-57346	NN	denotes	dermis
T12312	57346-57347	-RRB-	denotes	)
T12313	57347-57349	,	denotes	,
T12314	57349-57361	RB	denotes	individually
T12315	57362-57367	VBN	denotes	fixed
T12316	57368-57371	IN	denotes	for
T12317	57372-57373	CD	denotes	1
T12318	57374-57375	NN	denotes	h
T12319	57375-57377	,	denotes	,
T12320	57377-57381	RB	denotes	then
T12321	57382-57388	VBD	denotes	rinsed
T12322	57389-57392	CC	denotes	and
T12323	57393-57400	VBD	denotes	stained
T12324	57401-57405	IN	denotes	with
T12325	57406-57409	CD	denotes	0.1
T12326	57409-57410	NN	denotes	%
T12327	57413-57417	NN	denotes	DOPA
T12328	57411-57412	NN	denotes	L
T12329	57412-57413	HYPH	denotes	-
T12330	57486-57492	NN	denotes	buffer
T12331	57418-57419	-LRB-	denotes	(
T12332	57419-57424	NNP	denotes	Sigma
T12333	57424-57426	,	denotes	,
T12334	57426-57429	NNP	denotes	St.
T12335	57430-57435	NNP	denotes	Louis
T12336	57435-57437	,	denotes	,
T12337	57437-57445	NNP	denotes	Missouri
T12338	57445-57447	,	denotes	,
T12339	57447-57453	NNP	denotes	United
T12340	57454-57460	NNP	denotes	States
T12341	57460-57461	-RRB-	denotes	)
T12342	57461-57463	,	denotes	,
T12343	57463-57466	CD	denotes	0.1
T12344	57467-57468	NN	denotes	M
T12345	57476-57485	NN	denotes	phosphate
T12346	57469-57475	NN	denotes	sodium
T12347	57493-57494	-LRB-	denotes	(
T12348	57494-57496	NN	denotes	pH
T12349	57497-57500	CD	denotes	6.8
T12350	57500-57501	-RRB-	denotes	)
T12351	57502-57505	IN	denotes	for
T12352	57506-57507	CD	denotes	5
T12353	57508-57509	NN	denotes	h
T12354	57510-57512	IN	denotes	at
T12355	57513-57515	CD	denotes	37
T12356	57515-57517	NN	denotes	°C
T12357	57518-57520	IN	denotes	in
T12358	57521-57524	DT	denotes	the
T12359	57525-57529	NN	denotes	dark
T12360	57529-57531	,	denotes	,
T12361	57531-57539	VBG	denotes	changing
T12362	57540-57543	DT	denotes	the
T12363	57553-57561	NN	denotes	solution
T12364	57544-57552	NN	denotes	staining
T12365	57562-57567	IN	denotes	after
T12366	57568-57569	CD	denotes	1
T12367	57570-57571	NN	denotes	h
T12368	57571-57572	.	denotes	.
T12369	57572-57636	sentence	denotes	The samples were then fixed overnight, dehydrated, and mounted.
T12370	57573-57576	DT	denotes	The
T12371	57577-57584	NNS	denotes	samples
T12372	57595-57600	VBN	denotes	fixed
T12373	57585-57589	VBD	denotes	were
T12374	57590-57594	RB	denotes	then
T12375	57601-57610	RB	denotes	overnight
T12376	57610-57612	,	denotes	,
T12377	57612-57622	VBN	denotes	dehydrated
T12378	57622-57624	,	denotes	,
T12379	57624-57627	CC	denotes	and
T12380	57628-57635	VBN	denotes	mounted
T12381	57635-57636	.	denotes	.
T12382	57636-57735	sentence	denotes	This method is sufficient to stain interfollicular melanocytes without creating a high background.
T12383	57637-57641	DT	denotes	This
T12384	57642-57648	NN	denotes	method
T12385	57649-57651	VBZ	denotes	is
T12386	57652-57662	JJ	denotes	sufficient
T12387	57663-57665	TO	denotes	to
T12388	57666-57671	VB	denotes	stain
T12389	57672-57687	JJ	denotes	interfollicular
T12390	57688-57699	NNS	denotes	melanocytes
T12391	57700-57707	IN	denotes	without
T12392	57708-57716	VBG	denotes	creating
T12393	57717-57718	DT	denotes	a
T12394	57724-57734	NN	denotes	background
T12395	57719-57723	JJ	denotes	high
T12396	57734-57735	.	denotes	.
T12397	57735-57785	sentence	denotes	The fixative used was always 4% paraformaldehyde.
T12398	57736-57739	DT	denotes	The
T12399	57740-57748	JJ	denotes	fixative
T12400	57754-57757	VBD	denotes	was
T12401	57749-57753	VBN	denotes	used
T12402	57758-57764	RB	denotes	always
T12403	57765-57766	CD	denotes	4
T12404	57766-57767	NN	denotes	%
T12405	57768-57784	NN	denotes	paraformaldehyde
T12406	57784-57785	.	denotes	.
T12538	57787-57797	JJ	denotes	Positional
T12539	57798-57805	NN	denotes	cloning
T12540	57805-57919	sentence	denotes	A high-resolution map for deH was generated from an intersubspecific intercross between deH/deH and CAST/Ei mice.
T12541	57806-57807	DT	denotes	A
T12542	57824-57827	NN	denotes	map
T12543	57808-57812	JJ	denotes	high
T12544	57813-57823	NN	denotes	resolution
T12545	57812-57813	HYPH	denotes	-
T12546	57840-57849	VBN	denotes	generated
T12547	57828-57831	IN	denotes	for
T12548	57832-57835	NN	denotes	deH
T12549	57836-57839	VBD	denotes	was
T12550	57850-57854	IN	denotes	from
T12551	57855-57857	DT	denotes	an
T12552	57875-57885	NN	denotes	intercross
T12553	57858-57874	JJ	denotes	intersubspecific
T12554	57886-57893	IN	denotes	between
T12555	57894-57897	NN	denotes	deH
T12556	57898-57901	NN	denotes	deH
T12557	57897-57898	HYPH	denotes	/
T12558	57914-57918	NNS	denotes	mice
T12559	57902-57905	CC	denotes	and
T12560	57906-57910	NN	denotes	CAST
T12561	57911-57913	NN	denotes	Ei
T12562	57910-57911	HYPH	denotes	/
T12563	57918-57919	.	denotes	.
T12564	57919-57995	sentence	denotes	We initially localized deH to a 1 cM interval between D3Mit233 and D3Mit11.
T12565	57920-57922	PRP	denotes	We
T12566	57933-57942	VBD	denotes	localized
T12567	57923-57932	RB	denotes	initially
T12568	57943-57946	NN	denotes	deH
T12569	57947-57949	IN	denotes	to
T12570	57950-57951	DT	denotes	a
T12571	57957-57965	NN	denotes	interval
T12572	57952-57953	CD	denotes	1
T12573	57954-57956	NN	denotes	cM
T12574	57966-57973	IN	denotes	between
T12575	57974-57982	NN	denotes	D3Mit233
T12576	57983-57986	CC	denotes	and
T12577	57987-57994	NN	denotes	D3Mit11
T12578	57994-57995	.	denotes	.
T12579	57995-58167	sentence	denotes	F2 animals carrying recombinant chromosomes between these markers whose genotype at de was indeterminate (deH/+ or +/+) were progeny-tested by crossing to deH/deH animals.
T12580	57996-57998	NN	denotes	F2
T12581	57999-58006	NNS	denotes	animals
T12582	58129-58135	VBN	denotes	tested
T12583	58007-58015	VBG	denotes	carrying
T12584	58016-58027	JJ	denotes	recombinant
T12585	58028-58039	NNS	denotes	chromosomes
T12586	58040-58047	IN	denotes	between
T12587	58048-58053	DT	denotes	these
T12588	58054-58061	NNS	denotes	markers
T12589	58062-58067	WP$	denotes	whose
T12590	58068-58076	NN	denotes	genotype
T12591	58083-58086	VBD	denotes	was
T12592	58077-58079	IN	denotes	at
T12593	58080-58082	NN	denotes	de
T12594	58087-58100	JJ	denotes	indeterminate
T12595	58101-58102	-LRB-	denotes	(
T12596	58102-58105	NN	denotes	deH
T12597	58105-58106	HYPH	denotes	/
T12598	58106-58107	SYM	denotes	+
T12599	58108-58110	CC	denotes	or
T12600	58111-58112	SYM	denotes	+
T12601	58113-58114	SYM	denotes	+
T12602	58112-58113	HYPH	denotes	/
T12603	58114-58115	-RRB-	denotes	)
T12604	58116-58120	VBD	denotes	were
T12605	58121-58128	NN	denotes	progeny
T12606	58128-58129	HYPH	denotes	-
T12607	58136-58138	IN	denotes	by
T12608	58139-58147	VBG	denotes	crossing
T12609	58148-58150	IN	denotes	to
T12610	58151-58154	NN	denotes	deH
T12611	58155-58158	NN	denotes	deH
T12612	58154-58155	HYPH	denotes	/
T12613	58159-58166	NNS	denotes	animals
T12614	58166-58167	.	denotes	.
T12615	58167-58471	sentence	denotes	Further genetic mapping established a minimal region of 0.1 cM between D3Mit213 and 16.MMHAP32FLF1; these markers were used to initiate construction of a physical map with BAC genomic clones (Research Genetics, Huntsville, Alabama, United States, and Genome Systems, St. Louis, Missouri, United States).
T12616	58168-58175	JJ	denotes	Further
T12617	58184-58191	NN	denotes	mapping
T12618	58176-58183	JJ	denotes	genetic
T12619	58192-58203	VBD	denotes	established
T12620	58287-58291	VBN	denotes	used
T12621	58204-58205	DT	denotes	a
T12622	58214-58220	NN	denotes	region
T12623	58206-58213	JJ	denotes	minimal
T12624	58221-58223	IN	denotes	of
T12625	58224-58227	CD	denotes	0.1
T12626	58228-58230	NN	denotes	cM
T12627	58231-58238	IN	denotes	between
T12628	58239-58247	NN	denotes	D3Mit213
T12629	58248-58251	CC	denotes	and
T12630	58252-58266	NN	denotes	16.MMHAP32FLF1
T12631	58266-58267	:	denotes	;
T12632	58268-58273	DT	denotes	these
T12633	58274-58281	NNS	denotes	markers
T12634	58282-58286	VBD	denotes	were
T12635	58292-58294	TO	denotes	to
T12636	58295-58303	VB	denotes	initiate
T12637	58304-58316	NN	denotes	construction
T12638	58317-58319	IN	denotes	of
T12639	58320-58321	DT	denotes	a
T12640	58331-58334	NN	denotes	map
T12641	58322-58330	JJ	denotes	physical
T12642	58335-58339	IN	denotes	with
T12643	58340-58343	NN	denotes	BAC
T12644	58352-58358	NNS	denotes	clones
T12645	58344-58351	JJ	denotes	genomic
T12646	58359-58360	-LRB-	denotes	(
T12647	58369-58377	NNP	denotes	Genetics
T12648	58360-58368	NNP	denotes	Research
T12649	58377-58379	,	denotes	,
T12650	58379-58389	NNP	denotes	Huntsville
T12651	58389-58391	,	denotes	,
T12652	58391-58398	NNP	denotes	Alabama
T12653	58398-58400	,	denotes	,
T12654	58400-58406	NNP	denotes	United
T12655	58407-58413	NNP	denotes	States
T12656	58413-58415	,	denotes	,
T12657	58415-58418	CC	denotes	and
T12658	58419-58425	NNP	denotes	Genome
T12659	58426-58433	NNP	denotes	Systems
T12660	58433-58435	,	denotes	,
T12661	58435-58438	NNP	denotes	St.
T12662	58439-58444	NNP	denotes	Louis
T12663	58444-58446	,	denotes	,
T12664	58446-58454	NNP	denotes	Missouri
T12665	58454-58456	,	denotes	,
T12666	58456-58462	NNP	denotes	United
T12667	58463-58469	NNP	denotes	States
T12668	58469-58470	-RRB-	denotes	)
T12669	58470-58471	.	denotes	.
T12670	58471-58624	sentence	denotes	End sequence from those BACs was used to develop SSCP markers M1 to M3, as depicted in Figure 3, and to establish a minimal physical interval of 1.4 Mb.
T12671	58472-58475	NN	denotes	End
T12672	58476-58484	NN	denotes	sequence
T12673	58505-58509	VBN	denotes	used
T12674	58485-58489	IN	denotes	from
T12675	58490-58495	DT	denotes	those
T12676	58496-58500	NNS	denotes	BACs
T12677	58501-58504	VBD	denotes	was
T12678	58510-58512	TO	denotes	to
T12679	58513-58520	VB	denotes	develop
T12680	58521-58525	NN	denotes	SSCP
T12681	58526-58533	NNS	denotes	markers
T12682	58534-58536	NN	denotes	M1
T12683	58537-58539	IN	denotes	to
T12684	58540-58542	NN	denotes	M3
T12685	58542-58544	,	denotes	,
T12686	58544-58546	IN	denotes	as
T12687	58547-58555	VBN	denotes	depicted
T12688	58556-58558	IN	denotes	in
T12689	58559-58565	NN	denotes	Figure
T12690	58566-58567	CD	denotes	3
T12691	58567-58569	,	denotes	,
T12692	58569-58572	CC	denotes	and
T12693	58573-58575	TO	denotes	to
T12694	58576-58585	VB	denotes	establish
T12695	58586-58587	DT	denotes	a
T12696	58605-58613	NN	denotes	interval
T12697	58588-58595	JJ	denotes	minimal
T12698	58596-58604	JJ	denotes	physical
T12699	58614-58616	IN	denotes	of
T12700	58617-58620	CD	denotes	1.4
T12701	58621-58623	NN	denotes	Mb
T12702	58623-58624	.	denotes	.
T12703	58624-58953	sentence	denotes	Primer pairs used were TTCCCTCCAATAAGTTCTGGGTACC and AAGCTTGCTGCTCTGGATTCCATTTGTAG for M1, CCTTCATTTTTTTTTCAAGTAAAA and AAGCTTGGCTTAGTCCCAGTGGC for M2, CCTCCAGGAAGATCTACTAGGCAC and ATGGAAAAAAAAAAGTAAGATTGAAAG for M3, and TGGTTATCGATCTGTGGACCATTC and AAGTGAGAGAGCAGGATGGACCAC for M4 (the M4 marker represents STS 16.MMHAP32FLF1).
T12704	58625-58631	NN	denotes	Primer
T12705	58632-58637	NNS	denotes	pairs
T12706	58643-58647	VBD	denotes	were
T12707	58638-58642	VBN	denotes	used
T12708	58648-58673	NN	denotes	TTCCCTCCAATAAGTTCTGGGTACC
T12709	58674-58677	CC	denotes	and
T12710	58678-58707	NN	denotes	AAGCTTGCTGCTCTGGATTCCATTTGTAG
T12711	58708-58711	IN	denotes	for
T12712	58712-58714	NN	denotes	M1
T12713	58714-58716	,	denotes	,
T12714	58716-58740	NN	denotes	CCTTCATTTTTTTTTCAAGTAAAA
T12715	58741-58744	CC	denotes	and
T12716	58745-58768	NN	denotes	AAGCTTGGCTTAGTCCCAGTGGC
T12717	58769-58772	IN	denotes	for
T12718	58773-58775	NN	denotes	M2
T12719	58775-58777	,	denotes	,
T12720	58777-58801	NN	denotes	CCTCCAGGAAGATCTACTAGGCAC
T12721	58802-58805	CC	denotes	and
T12722	58806-58833	NN	denotes	ATGGAAAAAAAAAAGTAAGATTGAAAG
T12723	58834-58837	IN	denotes	for
T12724	58838-58840	NN	denotes	M3
T12725	58840-58842	,	denotes	,
T12726	58842-58845	CC	denotes	and
T12727	58846-58870	NN	denotes	TGGTTATCGATCTGTGGACCATTC
T12728	58871-58874	CC	denotes	and
T12729	58875-58899	NN	denotes	AAGTGAGAGAGCAGGATGGACCAC
T12730	58900-58903	IN	denotes	for
T12731	58904-58906	NN	denotes	M4
T12732	58907-58908	-LRB-	denotes	(
T12733	58922-58932	VBZ	denotes	represents
T12734	58908-58911	DT	denotes	the
T12735	58915-58921	NN	denotes	marker
T12736	58912-58914	NN	denotes	M4
T12737	58933-58936	NN	denotes	STS
T12738	58937-58951	NN	denotes	16.MMHAP32FLF1
T12739	58951-58952	-RRB-	denotes	)
T12740	58952-58953	.	denotes	.
T12741	58953-59353	sentence	denotes	Genomic sequence and annotations were obtained from the UCSC Genome Browser February 2003 assembly version mm3 (http://genome.ucsc.edu); the 1.4 Mb interval between M1 and M4 contains eight genes: four hydroxysteroid dehydrogenase isomerases, Hsd3b3, Hsd3b2, Hsd3b6, and Hsd3b1; an hydroacid oxidase, Hao3; a tryptophanyl-tRNA synthetase, Wars2; a T-box gene, Tbx15; and a novel gene, 4931427F14Rik.
T12742	58954-58961	JJ	denotes	Genomic
T12743	58962-58970	NN	denotes	sequence
T12744	58992-59000	VBN	denotes	obtained
T12745	58971-58974	CC	denotes	and
T12746	58975-58986	NNS	denotes	annotations
T12747	58987-58991	VBD	denotes	were
T12748	59129-59137	VBZ	denotes	contains
T12749	59001-59005	IN	denotes	from
T12750	59006-59009	DT	denotes	the
T12751	59022-59029	NN	denotes	Browser
T12752	59010-59014	NN	denotes	UCSC
T12753	59015-59021	NN	denotes	Genome
T12754	59061-59064	NN	denotes	mm3
T12755	59030-59038	NNP	denotes	February
T12756	59044-59052	NN	denotes	assembly
T12757	59039-59043	CD	denotes	2003
T12758	59053-59060	NN	denotes	version
T12759	59065-59066	-LRB-	denotes	(
T12760	59066-59088	NN	denotes	http://genome.ucsc.edu
T12761	59088-59089	-RRB-	denotes	)
T12762	59089-59090	:	denotes	;
T12763	59091-59094	DT	denotes	the
T12764	59102-59110	NN	denotes	interval
T12765	59095-59098	CD	denotes	1.4
T12766	59099-59101	NN	denotes	Mb
T12767	59111-59118	IN	denotes	between
T12768	59119-59121	NN	denotes	M1
T12769	59122-59125	CC	denotes	and
T12770	59126-59128	NN	denotes	M4
T12771	59138-59143	CD	denotes	eight
T12772	59144-59149	NNS	denotes	genes
T12773	59149-59151	:	denotes	:
T12774	59151-59155	CD	denotes	four
T12775	59185-59195	NNS	denotes	isomerases
T12776	59156-59170	NN	denotes	hydroxysteroid
T12777	59171-59184	NN	denotes	dehydrogenase
T12778	59195-59197	,	denotes	,
T12779	59197-59203	NN	denotes	Hsd3b3
T12780	59203-59205	,	denotes	,
T12781	59205-59211	NN	denotes	Hsd3b2
T12782	59211-59213	,	denotes	,
T12783	59213-59219	NN	denotes	Hsd3b6
T12784	59219-59221	,	denotes	,
T12785	59221-59224	CC	denotes	and
T12786	59225-59231	NN	denotes	Hsd3b1
T12787	59231-59232	,	denotes	;
T12788	59233-59235	DT	denotes	an
T12789	59246-59253	NN	denotes	oxidase
T12790	59236-59245	NN	denotes	hydroacid
T12791	59253-59255	,	denotes	,
T12792	59255-59259	NN	denotes	Hao3
T12793	59259-59260	,	denotes	;
T12794	59261-59262	DT	denotes	a
T12795	59281-59291	NN	denotes	synthetase
T12796	59263-59275	NN	denotes	tryptophanyl
T12797	59276-59280	NN	denotes	tRNA
T12798	59275-59276	HYPH	denotes	-
T12799	59291-59293	,	denotes	,
T12800	59293-59298	NN	denotes	Wars2
T12801	59298-59299	,	denotes	;
T12802	59300-59301	DT	denotes	a
T12803	59308-59312	NN	denotes	gene
T12804	59302-59303	NN	denotes	T
T12805	59304-59307	NN	denotes	box
T12806	59303-59304	HYPH	denotes	-
T12807	59312-59314	,	denotes	,
T12808	59314-59319	NN	denotes	Tbx15
T12809	59319-59320	,	denotes	;
T12810	59321-59324	CC	denotes	and
T12811	59325-59326	DT	denotes	a
T12812	59333-59337	NN	denotes	gene
T12813	59327-59332	JJ	denotes	novel
T12814	59337-59339	,	denotes	,
T12815	59339-59352	NN	denotes	4931427F14Rik
T12816	59352-59353	.	denotes	.
T12817	59353-59620	sentence	denotes	In the genome sequence, M1 primers correspond to AGGCCTCCAATAAGTTCTGGGTACC and AAGCTTGCTCTCTGGATTCCATTTGTAG, the M2 reverse primer corresponds to AAGCTTGGCTTTAGTCCCAGTGGGC, and the M3 primers correspond to CCTCCAGGAAGAATCTACTAGGCAC and AATGAAAAAAAAAAAAGTAAGATTGAAAG.
T12818	59354-59356	IN	denotes	In
T12819	59389-59399	VBP	denotes	correspond
T12820	59357-59360	DT	denotes	the
T12821	59368-59376	NN	denotes	sequence
T12822	59361-59367	NN	denotes	genome
T12823	59376-59378	,	denotes	,
T12824	59378-59380	NN	denotes	M1
T12825	59381-59388	NNS	denotes	primers
T12826	59400-59402	IN	denotes	to
T12827	59403-59428	NN	denotes	AGGCCTCCAATAAGTTCTGGGTACC
T12828	59429-59432	CC	denotes	and
T12829	59433-59461	NN	denotes	AAGCTTGCTCTCTGGATTCCATTTGTAG
T12830	59461-59463	,	denotes	,
T12831	59463-59466	DT	denotes	the
T12832	59478-59484	NN	denotes	primer
T12833	59467-59469	NN	denotes	M2
T12834	59470-59477	JJ	denotes	reverse
T12835	59485-59496	VBZ	denotes	corresponds
T12836	59497-59499	IN	denotes	to
T12837	59500-59525	NN	denotes	AAGCTTGGCTTTAGTCCCAGTGGGC
T12838	59525-59527	,	denotes	,
T12839	59527-59530	CC	denotes	and
T12840	59531-59534	DT	denotes	the
T12841	59538-59545	NNS	denotes	primers
T12842	59535-59537	NN	denotes	M3
T12843	59546-59556	VBP	denotes	correspond
T12844	59557-59559	IN	denotes	to
T12845	59560-59585	NN	denotes	CCTCCAGGAAGAATCTACTAGGCAC
T12846	59586-59589	CC	denotes	and
T12847	59590-59619	NN	denotes	AATGAAAAAAAAAAAAGTAAGATTGAAAG
T12848	59619-59620	.	denotes	.
T12849	59620-59804	sentence	denotes	Minor differences among the sequences of the primers we obtained from the BAC ends and the public genome sequence may represent strain differences or sequencing errors on the BAC DNA.
T12850	59621-59626	JJ	denotes	Minor
T12851	59627-59638	NNS	denotes	differences
T12852	59739-59748	VB	denotes	represent
T12853	59639-59644	IN	denotes	among
T12854	59645-59648	DT	denotes	the
T12855	59649-59658	NNS	denotes	sequences
T12856	59659-59661	IN	denotes	of
T12857	59662-59665	DT	denotes	the
T12858	59666-59673	NNS	denotes	primers
T12859	59674-59676	PRP	denotes	we
T12860	59677-59685	VBD	denotes	obtained
T12861	59686-59690	IN	denotes	from
T12862	59691-59694	DT	denotes	the
T12863	59695-59698	NN	denotes	BAC
T12864	59699-59703	VBZ	denotes	ends
T12865	59704-59707	CC	denotes	and
T12866	59708-59711	DT	denotes	the
T12867	59726-59734	NN	denotes	sequence
T12868	59712-59718	JJ	denotes	public
T12869	59719-59725	NN	denotes	genome
T12870	59735-59738	MD	denotes	may
T12871	59749-59755	NN	denotes	strain
T12872	59756-59767	NNS	denotes	differences
T12873	59768-59770	CC	denotes	or
T12874	59771-59781	NN	denotes	sequencing
T12875	59782-59788	NNS	denotes	errors
T12876	59789-59791	IN	denotes	on
T12877	59792-59795	DT	denotes	the
T12878	59800-59803	NN	denotes	DNA
T12879	59796-59799	NN	denotes	BAC
T12880	59803-59804	.	denotes	.
T12881	59804-59964	sentence	denotes	A multiplex genotyping assay was developed to genotype for the deH deletion using primers GGAGCAGATCCAATTGCTTT, TCCATAGCCCATCTTCACAA, and CATGTCCACTTCTGCTTCCA.
T12882	59805-59806	DT	denotes	A
T12883	59828-59833	NN	denotes	assay
T12884	59807-59816	JJ	denotes	multiplex
T12885	59817-59827	VBG	denotes	genotyping
T12886	59838-59847	VBN	denotes	developed
T12887	59834-59837	VBD	denotes	was
T12888	59848-59850	TO	denotes	to
T12889	59851-59859	VB	denotes	genotype
T12890	59860-59863	IN	denotes	for
T12891	59864-59867	DT	denotes	the
T12892	59872-59880	NN	denotes	deletion
T12893	59868-59871	NN	denotes	deH
T12894	59881-59886	VBG	denotes	using
T12895	59887-59894	NNS	denotes	primers
T12896	59895-59915	NN	denotes	GGAGCAGATCCAATTGCTTT
T12897	59915-59917	,	denotes	,
T12898	59917-59937	NN	denotes	TCCATAGCCCATCTTCACAA
T12899	59937-59939	,	denotes	,
T12900	59939-59942	CC	denotes	and
T12901	59943-59963	NN	denotes	CATGTCCACTTCTGCTTCCA
T12902	59963-59964	.	denotes	.
T12903	59964-60081	sentence	denotes	This PCR assay produces a 392 bp product from the deH chromosome and a 595 bp product from the nonmutant chromosome.
T12904	59965-59969	DT	denotes	This
T12905	59974-59979	NN	denotes	assay
T12906	59970-59973	NN	denotes	PCR
T12907	59980-59988	VBZ	denotes	produces
T12908	59989-59990	DT	denotes	a
T12909	59998-60005	NN	denotes	product
T12910	59991-59994	CD	denotes	392
T12911	59995-59997	NN	denotes	bp
T12912	60006-60010	IN	denotes	from
T12913	60011-60014	DT	denotes	the
T12914	60019-60029	NN	denotes	chromosome
T12915	60015-60018	NN	denotes	deH
T12916	60030-60033	CC	denotes	and
T12917	60034-60035	DT	denotes	a
T12918	60043-60050	NN	denotes	product
T12919	60036-60039	CD	denotes	595
T12920	60040-60042	NN	denotes	bp
T12921	60051-60055	IN	denotes	from
T12922	60056-60059	DT	denotes	the
T12923	60070-60080	NN	denotes	chromosome
T12924	60060-60069	JJ	denotes	nonmutant
T12925	60080-60081	.	denotes	.
T12999	60288-60296	VBN	denotes	inserted
T13000	60201-60206	NN	denotes	brief
T13001	60206-60208	,	denotes	,
T13002	60208-60210	DT	denotes	an
T13003	60225-60233	NN	denotes	cassette
T13004	60211-60215	NN	denotes	IRES
T13005	60221-60224	NN	denotes	neo
T13006	60215-60216	HYPH	denotes	-
T13007	60216-60220	NN	denotes	LacZ
T13008	60220-60221	HYPH	denotes	-
T13009	60234-60238	IN	denotes	with
T13010	60239-60240	CD	denotes	5
T13011	60258-60262	NNS	denotes	arms
T13012	60240-60241	SYM	denotes	′
T13013	60242-60245	CC	denotes	and
T13014	60246-60247	CD	denotes	3
T13015	60247-60248	SYM	denotes	′
T13016	60249-60257	NN	denotes	homology
T13017	60263-60265	IN	denotes	of
T13018	60266-60269	CD	denotes	3.5
T13019	60270-60272	NN	denotes	kb
T13020	60273-60276	CC	denotes	and
T13021	60277-60280	CD	denotes	1.8
T13022	60281-60283	NN	denotes	kb
T13023	60284-60287	VBD	denotes	was
T13024	60297-60301	IN	denotes	into
T13025	60302-60303	DT	denotes	a
T13026	60317-60321	NN	denotes	site
T13027	60304-60310	JJ	denotes	unique
T13028	60311-60316	NN	denotes	BamHI
T13029	60322-60326	WDT	denotes	that
T13030	60327-60331	VBZ	denotes	lies
T13031	60332-60335	CD	denotes	479
T13032	60336-60347	NNS	denotes	nucleotides
T13033	60348-60358	RB	denotes	downstream
T13034	60359-60361	IN	denotes	of
T13035	60362-60365	DT	denotes	the
T13036	60393-60397	NN	denotes	site
T13037	60366-60381	JJ	denotes	transcriptional
T13038	60382-60392	NN	denotes	initiation
T13039	60398-60399	-LRB-	denotes	(
T13040	60399-60407	JJ	denotes	relative
T13041	60408-60410	IN	denotes	to
T13042	60411-60414	DT	denotes	the
T13043	60420-60428	NN	denotes	sequence
T13044	60415-60419	NN	denotes	mRNA
T13045	60428-60429	-RRB-	denotes	)
T13046	60430-60432	IN	denotes	in
T13047	60433-60437	NN	denotes	exon
T13048	60438-60439	CD	denotes	3
T13049	60439-60440	.	denotes	.
T13050	60440-60563	sentence	denotes	Positive ES clones were injected into B6 blastocysts, and chimeric founders crossed to either B6 mice or to deH/+ animals.
T13051	60441-60449	JJ	denotes	Positive
T13052	60453-60459	NNS	denotes	clones
T13053	60450-60452	NN	denotes	ES
T13054	60465-60473	VBN	denotes	injected
T13055	60460-60464	VBD	denotes	were
T13056	60474-60478	IN	denotes	into
T13057	60479-60481	NN	denotes	B6
T13058	60482-60493	NNS	denotes	blastocysts
T13059	60493-60495	,	denotes	,
T13060	60495-60498	CC	denotes	and
T13061	60499-60507	JJ	denotes	chimeric
T13062	60508-60516	NNS	denotes	founders
T13063	60517-60524	VBN	denotes	crossed
T13064	60525-60527	IN	denotes	to
T13065	60528-60534	CC	denotes	either
T13066	60538-60542	NNS	denotes	mice
T13067	60535-60537	NN	denotes	B6
T13068	60543-60545	CC	denotes	or
T13069	60546-60548	IN	denotes	to
T13070	60549-60552	NN	denotes	deH
T13071	60555-60562	NNS	denotes	animals
T13072	60552-60553	HYPH	denotes	/
T13073	60553-60554	SYM	denotes	+
T13074	60562-60563	.	denotes	.
T13131	60565-60567	FW	denotes	In
T13132	60568-60572	FW	denotes	situ
T13133	60573-60586	NN	denotes	hybridization
T13134	60586-60806	sentence	denotes	In situ hybridization was carried out on 12-μm paraffin sections using digoxigenin-labeled RNA probes (Roche Diagnostics, Indianapolis, Indiana, United States) according to standard protocols (Wilkinson and Nieto 1993).
T13135	60587-60589	FW	denotes	In
T13136	60590-60594	FW	denotes	situ
T13137	60595-60608	NN	denotes	hybridization
T13138	60613-60620	VBN	denotes	carried
T13139	60609-60612	VBD	denotes	was
T13140	60621-60624	RP	denotes	out
T13141	60625-60627	IN	denotes	on
T13142	60628-60630	CD	denotes	12
T13143	60631-60633	NN	denotes	μm
T13144	60630-60631	HYPH	denotes	-
T13145	60643-60651	NNS	denotes	sections
T13146	60634-60642	NN	denotes	paraffin
T13147	60652-60657	VBG	denotes	using
T13148	60658-60669	NN	denotes	digoxigenin
T13149	60670-60677	VBN	denotes	labeled
T13150	60669-60670	HYPH	denotes	-
T13151	60682-60688	NNS	denotes	probes
T13152	60678-60681	NN	denotes	RNA
T13153	60689-60690	-LRB-	denotes	(
T13154	60696-60707	NNP	denotes	Diagnostics
T13155	60690-60695	NNP	denotes	Roche
T13156	60707-60709	,	denotes	,
T13157	60709-60721	NNP	denotes	Indianapolis
T13158	60721-60723	,	denotes	,
T13159	60723-60730	NNP	denotes	Indiana
T13160	60730-60732	,	denotes	,
T13161	60732-60738	NNP	denotes	United
T13162	60739-60745	NNP	denotes	States
T13163	60745-60746	-RRB-	denotes	)
T13164	60747-60756	VBG	denotes	according
T13165	60757-60759	IN	denotes	to
T13166	60760-60768	JJ	denotes	standard
T13167	60769-60778	NNS	denotes	protocols
T13168	60779-60780	-LRB-	denotes	(
T13169	60780-60789	NNP	denotes	Wilkinson
T13170	60790-60793	CC	denotes	and
T13171	60794-60799	NNP	denotes	Nieto
T13172	60800-60804	CD	denotes	1993
T13173	60804-60805	-RRB-	denotes	)
T13174	60805-60806	.	denotes	.
T13175	60806-60888	sentence	denotes	Embryos and postnatal skin samples were obtained from intercrosses of deH/+ mice.
T13176	60807-60814	NNS	denotes	Embryos
T13177	60847-60855	VBN	denotes	obtained
T13178	60815-60818	CC	denotes	and
T13179	60819-60828	JJ	denotes	postnatal
T13180	60834-60841	NNS	denotes	samples
T13181	60829-60833	NN	denotes	skin
T13182	60842-60846	VBD	denotes	were
T13183	60856-60860	IN	denotes	from
T13184	60861-60873	NNS	denotes	intercrosses
T13185	60874-60876	IN	denotes	of
T13186	60877-60880	NN	denotes	deH
T13187	60883-60887	NNS	denotes	mice
T13188	60880-60881	HYPH	denotes	/
T13189	60881-60882	SYM	denotes	+
T13190	60887-60888	.	denotes	.
T13191	60888-61019	sentence	denotes	Embryos E13.5 or younger were fixed for 24 h; those older than E13.5 and postnatal skin were fixed for 36–48 h prior to embedding.
T13192	60889-60896	NNS	denotes	Embryos
T13193	60919-60924	VBN	denotes	fixed
T13194	60897-60902	NN	denotes	E13.5
T13195	60903-60905	CC	denotes	or
T13196	60906-60913	JJR	denotes	younger
T13197	60914-60918	VBD	denotes	were
T13198	60982-60987	VBN	denotes	fixed
T13199	60925-60928	IN	denotes	for
T13200	60929-60931	CD	denotes	24
T13201	60932-60933	NN	denotes	h
T13202	60933-60934	:	denotes	;
T13203	60935-60940	DT	denotes	those
T13204	60941-60946	JJR	denotes	older
T13205	60947-60951	IN	denotes	than
T13206	60952-60957	NN	denotes	E13.5
T13207	60958-60961	CC	denotes	and
T13208	60962-60971	JJ	denotes	postnatal
T13209	60972-60976	NN	denotes	skin
T13210	60977-60981	VBD	denotes	were
T13211	60988-60991	IN	denotes	for
T13212	60992-60994	CD	denotes	36
T13213	60995-60997	CD	denotes	48
T13214	60994-60995	SYM	denotes	–
T13215	60998-60999	NN	denotes	h
T13216	61000-61005	RB	denotes	prior
T13217	61006-61008	IN	denotes	to
T13218	61009-61018	VBG	denotes	embedding
T13219	61018-61019	.	denotes	.
T13220	61019-61294	sentence	denotes	The Tbx15 probe was generated by RT–PCR using primers GGCGGCTAAAATGAGTGAAC and TGCCTGCTTTGGTGATGAT (corresponds to exons 1 and 2), and the En1 probe was generated by PCR from genomic DNA using primers ACGCACCAGGAAGCTAAAGA and AGCAACGAAAACGAAACTGG (located in the last exon).
T13221	61020-61023	DT	denotes	The
T13222	61030-61035	NN	denotes	probe
T13223	61024-61029	NN	denotes	Tbx15
T13224	61040-61049	VBN	denotes	generated
T13225	61036-61039	VBD	denotes	was
T13226	61050-61052	IN	denotes	by
T13227	61053-61055	NN	denotes	RT
T13228	61056-61059	NN	denotes	PCR
T13229	61055-61056	HYPH	denotes	–
T13230	61060-61065	VBG	denotes	using
T13231	61066-61073	NNS	denotes	primers
T13232	61074-61094	NN	denotes	GGCGGCTAAAATGAGTGAAC
T13233	61095-61098	CC	denotes	and
T13234	61099-61118	NN	denotes	TGCCTGCTTTGGTGATGAT
T13235	61119-61120	-LRB-	denotes	(
T13236	61120-61131	VBZ	denotes	corresponds
T13237	61132-61134	IN	denotes	to
T13238	61135-61140	NNS	denotes	exons
T13239	61141-61142	CD	denotes	1
T13240	61143-61146	CC	denotes	and
T13241	61147-61148	CD	denotes	2
T13242	61148-61149	-RRB-	denotes	)
T13243	61149-61151	,	denotes	,
T13244	61151-61154	CC	denotes	and
T13245	61155-61158	DT	denotes	the
T13246	61163-61168	NN	denotes	probe
T13247	61159-61162	NN	denotes	En1
T13248	61173-61182	VBN	denotes	generated
T13249	61169-61172	VBD	denotes	was
T13250	61183-61185	IN	denotes	by
T13251	61186-61189	NN	denotes	PCR
T13252	61190-61194	IN	denotes	from
T13253	61195-61202	JJ	denotes	genomic
T13254	61203-61206	NN	denotes	DNA
T13255	61207-61212	VBG	denotes	using
T13256	61213-61220	NNS	denotes	primers
T13257	61221-61241	NN	denotes	ACGCACCAGGAAGCTAAAGA
T13258	61242-61245	CC	denotes	and
T13259	61246-61266	NN	denotes	AGCAACGAAAACGAAACTGG
T13260	61267-61268	-LRB-	denotes	(
T13261	61268-61275	VBN	denotes	located
T13262	61276-61278	IN	denotes	in
T13263	61279-61282	DT	denotes	the
T13264	61288-61292	NN	denotes	exon
T13265	61283-61287	JJ	denotes	last
T13266	61292-61293	-RRB-	denotes	)
T13267	61293-61294	.	denotes	.
T13268	61294-61355	sentence	denotes	The Agouti probe corresponds to the protein-coding sequence.
T13269	61295-61298	DT	denotes	The
T13270	61306-61311	NN	denotes	probe
T13271	61299-61305	NN	denotes	Agouti
T13272	61312-61323	VBZ	denotes	corresponds
T13273	61324-61326	IN	denotes	to
T13274	61327-61330	DT	denotes	the
T13275	61346-61354	NN	denotes	sequence
T13276	61331-61338	NN	denotes	protein
T13277	61339-61345	VBG	denotes	coding
T13278	61338-61339	HYPH	denotes	-
T13279	61354-61355	.	denotes	.
T13332	61357-61366	JJ	denotes	Embryonic
T13333	61372-61387	NN	denotes	transplantation
T13334	61367-61371	NN	denotes	skin
T13335	61387-61588	sentence	denotes	(BTBR-at/at × B6-a/a)F1 embryos at E12.5 were dissected in sterile Tyrode's solution, and embryonic skin was divided into dorsal, flank, and ventral pieces, each 1–2 mm2 in size, as shown in Figure 7.
T13336	61388-61389	-LRB-	denotes	(
T13337	61434-61443	VBN	denotes	dissected
T13338	61389-61393	NN	denotes	BTBR
T13339	61412-61419	NNS	denotes	embryos
T13340	61393-61394	HYPH	denotes	-
T13341	61394-61396	NN	denotes	at
T13342	61397-61399	NN	denotes	at
T13343	61396-61397	HYPH	denotes	/
T13344	61400-61401	SYM	denotes	×
T13345	61402-61404	NN	denotes	B6
T13346	61404-61405	HYPH	denotes	-
T13347	61405-61406	NN	denotes	a
T13348	61407-61408	NN	denotes	a
T13349	61406-61407	HYPH	denotes	/
T13350	61408-61409	-RRB-	denotes	)
T13351	61409-61411	NN	denotes	F1
T13352	61420-61422	IN	denotes	at
T13353	61423-61428	NN	denotes	E12.5
T13354	61429-61433	VBD	denotes	were
T13355	61444-61446	IN	denotes	in
T13356	61447-61454	JJ	denotes	sterile
T13357	61464-61472	NN	denotes	solution
T13358	61455-61461	NNP	denotes	Tyrode
T13359	61461-61463	POS	denotes	's
T13360	61472-61474	,	denotes	,
T13361	61474-61477	CC	denotes	and
T13362	61478-61487	JJ	denotes	embryonic
T13363	61488-61492	NN	denotes	skin
T13364	61497-61504	VBN	denotes	divided
T13365	61493-61496	VBD	denotes	was
T13366	61505-61509	IN	denotes	into
T13367	61510-61516	JJ	denotes	dorsal
T13368	61537-61543	NNS	denotes	pieces
T13369	61516-61518	,	denotes	,
T13370	61518-61523	NN	denotes	flank
T13371	61523-61525	,	denotes	,
T13372	61525-61528	CC	denotes	and
T13373	61529-61536	JJ	denotes	ventral
T13374	61543-61545	,	denotes	,
T13375	61545-61549	RB	denotes	each
T13376	61554-61557	NN	denotes	mm2
T13377	61550-61551	CD	denotes	1
T13378	61552-61553	CD	denotes	2
T13379	61551-61552	HYPH	denotes	–
T13380	61558-61560	IN	denotes	in
T13381	61561-61565	NN	denotes	size
T13382	61565-61567	,	denotes	,
T13383	61567-61569	IN	denotes	as
T13384	61570-61575	VBN	denotes	shown
T13385	61576-61578	IN	denotes	in
T13386	61579-61585	NN	denotes	Figure
T13387	61586-61587	CD	denotes	7
T13388	61587-61588	.	denotes	.
T13389	61588-61662	sentence	denotes	Skin fragments were grafted to the testes of congenic animals as follows.
T13390	61589-61593	NN	denotes	Skin
T13391	61594-61603	NNS	denotes	fragments
T13392	61609-61616	VBN	denotes	grafted
T13393	61604-61608	VBD	denotes	were
T13394	61617-61619	IN	denotes	to
T13395	61620-61623	DT	denotes	the
T13396	61624-61630	NNS	denotes	testes
T13397	61631-61633	IN	denotes	of
T13398	61634-61642	JJ	denotes	congenic
T13399	61643-61650	NNS	denotes	animals
T13400	61651-61653	IN	denotes	as
T13401	61654-61661	VBZ	denotes	follows
T13402	61661-61662	.	denotes	.
T13403	61662-61800	sentence	denotes	After anesthetization with 2.5% Avertin, a 1.5-cm incision in the skin and body wall was made at a point level with the top of the limbs.
T13404	61663-61668	IN	denotes	After
T13405	61752-61756	VBN	denotes	made
T13406	61669-61684	NN	denotes	anesthetization
T13407	61685-61689	IN	denotes	with
T13408	61690-61693	CD	denotes	2.5
T13409	61693-61694	NN	denotes	%
T13410	61695-61702	NN	denotes	Avertin
T13411	61702-61704	,	denotes	,
T13412	61704-61705	DT	denotes	a
T13413	61713-61721	NN	denotes	incision
T13414	61706-61709	CD	denotes	1.5
T13415	61710-61712	NN	denotes	cm
T13416	61709-61710	HYPH	denotes	-
T13417	61722-61724	IN	denotes	in
T13418	61725-61728	DT	denotes	the
T13419	61729-61733	NN	denotes	skin
T13420	61734-61737	CC	denotes	and
T13421	61738-61742	NN	denotes	body
T13422	61743-61747	NN	denotes	wall
T13423	61748-61751	VBD	denotes	was
T13424	61757-61759	IN	denotes	at
T13425	61760-61761	DT	denotes	a
T13426	61762-61767	NN	denotes	point
T13427	61768-61773	JJ	denotes	level
T13428	61774-61778	IN	denotes	with
T13429	61779-61782	DT	denotes	the
T13430	61783-61786	NN	denotes	top
T13431	61787-61789	IN	denotes	of
T13432	61790-61793	DT	denotes	the
T13433	61794-61799	NNS	denotes	limbs
T13434	61799-61800	.	denotes	.
T13435	61800-61887	sentence	denotes	The fat pads were pulled out and laid on the outside of the body, exposing the testes.
T13436	61801-61804	DT	denotes	The
T13437	61809-61813	NNS	denotes	pads
T13438	61805-61808	NN	denotes	fat
T13439	61819-61825	VBN	denotes	pulled
T13440	61814-61818	VBD	denotes	were
T13441	61826-61829	RP	denotes	out
T13442	61830-61833	CC	denotes	and
T13443	61834-61838	VBN	denotes	laid
T13444	61839-61841	IN	denotes	on
T13445	61842-61845	DT	denotes	the
T13446	61846-61853	NN	denotes	outside
T13447	61854-61856	IN	denotes	of
T13448	61857-61860	DT	denotes	the
T13449	61861-61865	NN	denotes	body
T13450	61865-61867	,	denotes	,
T13451	61867-61875	VBG	denotes	exposing
T13452	61876-61879	DT	denotes	the
T13453	61880-61886	NNS	denotes	testes
T13454	61886-61887	.	denotes	.
T13455	61887-62135	sentence	denotes	Forceps were used to introduce a small hole in the testis capsule through which a piece of dissected embryonic skin was inserted, the testes were then replaced into the abdominal cavity, and the wound was closed in both the body wall and the skin.
T13456	61888-61895	NNS	denotes	Forceps
T13457	61901-61905	VBN	denotes	used
T13458	61896-61900	VBD	denotes	were
T13459	61906-61908	TO	denotes	to
T13460	61909-61918	VB	denotes	introduce
T13461	61919-61920	DT	denotes	a
T13462	61927-61931	NN	denotes	hole
T13463	61921-61926	JJ	denotes	small
T13464	61932-61934	IN	denotes	in
T13465	61935-61938	DT	denotes	the
T13466	61946-61953	NN	denotes	capsule
T13467	61939-61945	NN	denotes	testis
T13468	61954-61961	IN	denotes	through
T13469	62008-62016	VBN	denotes	inserted
T13470	61962-61967	WDT	denotes	which
T13471	61968-61969	DT	denotes	a
T13472	61970-61975	NN	denotes	piece
T13473	61976-61978	IN	denotes	of
T13474	61979-61988	VBN	denotes	dissected
T13475	61999-62003	NN	denotes	skin
T13476	61989-61998	JJ	denotes	embryonic
T13477	62004-62007	VBD	denotes	was
T13478	62016-62018	,	denotes	,
T13479	62018-62021	DT	denotes	the
T13480	62022-62028	NNS	denotes	testes
T13481	62039-62047	VBN	denotes	replaced
T13482	62029-62033	VBD	denotes	were
T13483	62034-62038	RB	denotes	then
T13484	62048-62052	IN	denotes	into
T13485	62053-62056	DT	denotes	the
T13486	62067-62073	NN	denotes	cavity
T13487	62057-62066	JJ	denotes	abdominal
T13488	62073-62075	,	denotes	,
T13489	62075-62078	CC	denotes	and
T13490	62079-62082	DT	denotes	the
T13491	62083-62088	NN	denotes	wound
T13492	62093-62099	VBN	denotes	closed
T13493	62089-62092	VBD	denotes	was
T13494	62100-62102	IN	denotes	in
T13495	62103-62107	CC	denotes	both
T13496	62117-62121	NN	denotes	wall
T13497	62108-62111	DT	denotes	the
T13498	62112-62116	NN	denotes	body
T13499	62122-62125	CC	denotes	and
T13500	62126-62129	DT	denotes	the
T13501	62130-62134	NN	denotes	skin
T13502	62134-62135	.	denotes	.
T13503	62135-62259	sentence	denotes	After 21 days, mice that received grafts were sacrificed and the resulting hair was dissected from the testes and examined.
T13504	62136-62141	IN	denotes	After
T13505	62182-62192	VBN	denotes	sacrificed
T13506	62142-62144	CD	denotes	21
T13507	62145-62149	NNS	denotes	days
T13508	62149-62151	,	denotes	,
T13509	62151-62155	NNS	denotes	mice
T13510	62156-62160	WDT	denotes	that
T13511	62161-62169	VBD	denotes	received
T13512	62170-62176	NNS	denotes	grafts
T13513	62177-62181	VBD	denotes	were
T13514	62193-62196	CC	denotes	and
T13515	62197-62200	DT	denotes	the
T13516	62211-62215	NN	denotes	hair
T13517	62201-62210	VBG	denotes	resulting
T13518	62220-62229	VBN	denotes	dissected
T13519	62216-62219	VBD	denotes	was
T13520	62230-62234	IN	denotes	from
T13521	62235-62238	DT	denotes	the
T13522	62239-62245	NNS	denotes	testes
T13523	62246-62249	CC	denotes	and
T13524	62250-62258	VBN	denotes	examined
T13525	62258-62259	.	denotes	.
T13570	62261-62265	NN	denotes	Fate
T13571	62266-62273	VBG	denotes	mapping
T13572	62265-62266	HYPH	denotes	-
T13573	62274-62277	DT	denotes	the
T13574	62294-62302	NN	denotes	frontier
T13575	62278-62285	JJ	denotes	lateral
T13576	62286-62293	JJ	denotes	somitic
T13577	62302-62475	sentence	denotes	The Hoxb6-Cre transgene described by Kuehn and colleagues (Lowe et al. 2000) is expressed in the lateral plate but not the somitic mesoderm of the trunk, beginning at E9.5.
T13578	62303-62306	DT	denotes	The
T13579	62317-62326	NN	denotes	transgene
T13580	62307-62312	NN	denotes	Hoxb6
T13581	62313-62316	NN	denotes	Cre
T13582	62312-62313	HYPH	denotes	-
T13583	62383-62392	VBN	denotes	expressed
T13584	62327-62336	VBN	denotes	described
T13585	62337-62339	IN	denotes	by
T13586	62340-62345	NN	denotes	Kuehn
T13587	62346-62349	CC	denotes	and
T13588	62350-62360	NNS	denotes	colleagues
T13589	62361-62362	-LRB-	denotes	(
T13590	62362-62366	NNP	denotes	Lowe
T13591	62367-62369	FW	denotes	et
T13592	62370-62373	FW	denotes	al.
T13593	62374-62378	CD	denotes	2000
T13594	62378-62379	-RRB-	denotes	)
T13595	62380-62382	VBZ	denotes	is
T13596	62393-62395	IN	denotes	in
T13597	62396-62399	DT	denotes	the
T13598	62408-62413	NN	denotes	plate
T13599	62400-62407	JJ	denotes	lateral
T13600	62414-62417	CC	denotes	but
T13601	62418-62421	RB	denotes	not
T13602	62422-62425	DT	denotes	the
T13603	62434-62442	NN	denotes	mesoderm
T13604	62426-62433	JJ	denotes	somitic
T13605	62443-62445	IN	denotes	of
T13606	62446-62449	DT	denotes	the
T13607	62450-62455	NN	denotes	trunk
T13608	62455-62457	,	denotes	,
T13609	62457-62466	VBG	denotes	beginning
T13610	62467-62469	IN	denotes	at
T13611	62470-62474	NN	denotes	E9.5
T13612	62474-62475	.	denotes	.
T13613	62475-62602	sentence	denotes	Animals doubly heterozygous for this transgene and the R26R reporter gene were used as a source of whole skin at P1.5 or P4.5.
T13614	62476-62483	NNS	denotes	Animals
T13615	62555-62559	VBN	denotes	used
T13616	62484-62490	RB	denotes	doubly
T13617	62491-62503	JJ	denotes	heterozygous
T13618	62504-62507	IN	denotes	for
T13619	62508-62512	DT	denotes	this
T13620	62513-62522	NN	denotes	transgene
T13621	62523-62526	CC	denotes	and
T13622	62527-62530	DT	denotes	the
T13623	62545-62549	NN	denotes	gene
T13624	62531-62535	NN	denotes	R26R
T13625	62536-62544	NN	denotes	reporter
T13626	62550-62554	VBD	denotes	were
T13627	62560-62562	IN	denotes	as
T13628	62563-62564	DT	denotes	a
T13629	62565-62571	NN	denotes	source
T13630	62572-62574	IN	denotes	of
T13631	62575-62580	JJ	denotes	whole
T13632	62581-62585	NN	denotes	skin
T13633	62586-62588	IN	denotes	at
T13634	62589-62593	NN	denotes	P1.5
T13635	62594-62596	CC	denotes	or
T13636	62597-62601	NN	denotes	P4.5
T13637	62601-62602	.	denotes	.
T13638	62602-62800	sentence	denotes	Skin sections parallel to the dorsoventral axis were prepared with a single incision along the ventral midline and stained for β-galactosidase activity using standard protocols at room temperature.
T13639	62603-62607	NN	denotes	Skin
T13640	62608-62616	NNS	denotes	sections
T13641	62656-62664	VBN	denotes	prepared
T13642	62617-62625	JJ	denotes	parallel
T13643	62626-62628	IN	denotes	to
T13644	62629-62632	DT	denotes	the
T13645	62646-62650	NN	denotes	axis
T13646	62633-62645	JJ	denotes	dorsoventral
T13647	62651-62655	VBD	denotes	were
T13648	62665-62669	IN	denotes	with
T13649	62670-62671	DT	denotes	a
T13650	62679-62687	NN	denotes	incision
T13651	62672-62678	JJ	denotes	single
T13652	62688-62693	IN	denotes	along
T13653	62694-62697	DT	denotes	the
T13654	62706-62713	NN	denotes	midline
T13655	62698-62705	JJ	denotes	ventral
T13656	62714-62717	CC	denotes	and
T13657	62718-62725	VBN	denotes	stained
T13658	62726-62729	IN	denotes	for
T13659	62730-62731	NN	denotes	β
T13660	62732-62745	NN	denotes	galactosidase
T13661	62731-62732	HYPH	denotes	-
T13662	62746-62754	NN	denotes	activity
T13663	62755-62760	VBG	denotes	using
T13664	62761-62769	JJ	denotes	standard
T13665	62770-62779	NNS	denotes	protocols
T13666	62780-62782	IN	denotes	at
T13667	62783-62787	NN	denotes	room
T13668	62788-62799	NN	denotes	temperature
T13669	62799-62800	.	denotes	.
T13670	62800-62883	sentence	denotes	The P1.5 sample was stained overnight and the P4.5 samples were stained for 5.5 h.
T13671	62801-62804	DT	denotes	The
T13672	62810-62816	NN	denotes	sample
T13673	62805-62809	NN	denotes	P1.5
T13674	62821-62828	VBN	denotes	stained
T13675	62817-62820	VBD	denotes	was
T13676	62829-62838	RB	denotes	overnight
T13677	62839-62842	CC	denotes	and
T13678	62843-62846	DT	denotes	the
T13679	62852-62859	NNS	denotes	samples
T13680	62847-62851	NN	denotes	P4.5
T13681	62865-62872	VBN	denotes	stained
T13682	62860-62864	VBD	denotes	were
T13683	62873-62876	IN	denotes	for
T13684	62877-62880	CD	denotes	5.5
T13685	62881-62882	NN	denotes	h
T13686	62882-62883	.	denotes	.
T13687	62883-62967	sentence	denotes	Similar nonstained skin sections were prepared from animals carrying the at allele.
T13688	62884-62891	JJ	denotes	Similar
T13689	62908-62916	NNS	denotes	sections
T13690	62892-62902	JJ	denotes	nonstained
T13691	62903-62907	NN	denotes	skin
T13692	62922-62930	VBN	denotes	prepared
T13693	62917-62921	VBD	denotes	were
T13694	62931-62935	IN	denotes	from
T13695	62936-62943	NNS	denotes	animals
T13696	62944-62952	VBG	denotes	carrying
T13697	62953-62956	DT	denotes	the
T13698	62960-62966	NN	denotes	allele
T13699	62957-62959	NN	denotes	at
T13700	62966-62967	.	denotes	.
T13701	62967-63145	sentence	denotes	Images of the different skin fragments were aligned and scaled, and the relative position of the somite–lateral plate and the pigmentation boundaries were measured using ImageJ.
T13702	62968-62974	NNS	denotes	Images
T13703	63012-63019	VBN	denotes	aligned
T13704	62975-62977	IN	denotes	of
T13705	62978-62981	DT	denotes	the
T13706	62997-63006	NNS	denotes	fragments
T13707	62982-62991	JJ	denotes	different
T13708	62992-62996	NN	denotes	skin
T13709	63007-63011	VBD	denotes	were
T13710	63020-63023	CC	denotes	and
T13711	63024-63030	VBN	denotes	scaled
T13712	63030-63032	,	denotes	,
T13713	63032-63035	CC	denotes	and
T13714	63036-63039	DT	denotes	the
T13715	63049-63057	NN	denotes	position
T13716	63040-63048	JJ	denotes	relative
T13717	63123-63131	VBN	denotes	measured
T13718	63058-63060	IN	denotes	of
T13719	63061-63064	DT	denotes	the
T13720	63080-63085	NN	denotes	plate
T13721	63065-63071	NN	denotes	somite
T13722	63072-63079	JJ	denotes	lateral
T13723	63071-63072	HYPH	denotes	–
T13724	63086-63089	CC	denotes	and
T13725	63090-63093	DT	denotes	the
T13726	63107-63117	NNS	denotes	boundaries
T13727	63094-63106	NN	denotes	pigmentation
T13728	63118-63122	VBD	denotes	were
T13729	63132-63137	VBG	denotes	using
T13730	63138-63144	NN	denotes	ImageJ
T13731	63144-63145	.	denotes	.
T12974	60083-60087	NN	denotes	Gene
T12975	60088-60097	NN	denotes	targeting
T12976	60097-60197	sentence	denotes	A targeted allele of Tbx15 was constructed using the same approach described in Russ et al. (2000).
T12977	60098-60099	DT	denotes	A
T12978	60109-60115	NN	denotes	allele
T12979	60100-60108	VBN	denotes	targeted
T12980	60129-60140	VBN	denotes	constructed
T12981	60116-60118	IN	denotes	of
T12982	60119-60124	NN	denotes	Tbx15
T12983	60125-60128	VBD	denotes	was
T12984	60141-60146	VBG	denotes	using
T12985	60147-60150	DT	denotes	the
T12986	60156-60164	NN	denotes	approach
T12987	60151-60155	JJ	denotes	same
T12988	60165-60174	VBN	denotes	described
T12989	60175-60177	IN	denotes	in
T12990	60178-60182	NNP	denotes	Russ
T12991	60183-60185	FW	denotes	et
T12992	60186-60189	FW	denotes	al.
T12993	60190-60191	-LRB-	denotes	(
T12994	60191-60195	CD	denotes	2000
T12995	60195-60196	-RRB-	denotes	)
T12996	60196-60197	.	denotes	.
T12997	60197-60440	sentence	denotes	In brief, an IRES-LacZ-neo cassette with 5′ and 3′ homology arms of 3.5 kb and 1.8 kb was inserted into a unique BamHI site that lies 479 nucleotides downstream of the transcriptional initiation site (relative to the mRNA sequence) in exon 3.
T12998	60198-60200	IN	denotes	In
T169	0-12	JJ	denotes	Dorsoventral
T170	13-23	NN	denotes	Patterning
T2203	8877-8878	DT	denotes	a
T2204	8912-8918	NN	denotes	manner
T2205	8879-8886	JJ	denotes	dynamic
T2206	8887-8890	CC	denotes	and
T2207	8891-8900	RB	denotes	spatially
T2208	8901-8911	JJ	denotes	restricted
T2209	8919-8921	IN	denotes	in
T2210	8922-8925	DT	denotes	the
T2211	8937-8941	NN	denotes	skin
T2212	8926-8936	VBG	denotes	developing
T2213	8942-8945	CC	denotes	and
T2214	8946-8961	JJ	denotes	musculoskeletal
T2215	8962-8968	NN	denotes	system
T2216	8968-8969	.	denotes	.
T2217	8969-9153	sentence	denotes	Embryonic expression and transplantation studies suggest that Tbx15 is required to establish certain characteristics of dorsal patterning in mesenchymal cells of the developing flank.
T2218	8970-8979	JJ	denotes	Embryonic
T2219	9011-9018	NNS	denotes	studies
R92	T269	T270	det	the,boundary
R93	T270	T253	dobj	boundary,raises
R1	T172	T170	prep	of,Patterning
R2	T173	T174	det	the,Coat
R3	T174	T172	pobj	Coat,of
R5	T176	T170	prep	by,Patterning
R6	T177	T176	pobj	Tbx15,by
R7	T179	T180	amod	Many,members
R8	T180	T181	nsubj	members,display
R9	T182	T180	prep	of,members
R10	T183	T184	det	the,kingdom
R11	T184	T182	pobj	kingdom,of
R13	T186	T187	nmod	coat,differences
R14	T187	T181	dobj	differences,display
R18	T191	T181	prep	along,display
R19	T192	T193	poss	their,axis
R20	T193	T191	pobj	axis,along
R22	T195	T181	punct	.,display
R23	T197	T198	aux	To,determine
R24	T198	T199	advcl	determine,studied
R25	T200	T201	det	the,mechanisms
R26	T201	T198	dobj	mechanisms,determine
R27	T202	T203	dep	that,control
R28	T203	T201	relcl	control,mechanisms
R29	T204	T205	amod	regional,differences
R30	T205	T203	dobj	differences,control
R31	T206	T205	prep	in,differences
R32	T207	T206	pobj	pigmentation,in
R33	T208	T199	punct	", ",studied
R34	T209	T199	nsubj	we,studied
R35	T210	T199	aux	have,studied
R36	T211	T212	advmod	how,affects
R37	T212	T199	ccomp	affects,studied
R39	T214	T212	nsubj	mutation,affects
R40	T215	T214	amod	classical,mutation
R41	T216	T214	compound	mouse,mutation
R49	T224	T225	amod	dorsoventral,characteristics
R50	T225	T212	dobj	characteristics,affects
R52	T227	T225	punct	", ",characteristics
R53	T228	T229	advmod	especially,those
R54	T229	T225	appos	those,characteristics
R55	T230	T229	prep	under,those
R56	T231	T230	pobj	control,under
R57	T232	T231	prep	of,control
R58	T233	T234	det	the,gene
R59	T234	T232	pobj	gene,of
R61	T236	T199	punct	.,studied
R62	T238	T239	nsubj	Mice,have
R63	T239	T253	ccomp	have,raises
R66	T242	T240	dobj	allele,carrying
R67	T243	T242	compound	Agouti,allele
R77	T254	T255	det	a,boundary
R78	T255	T239	dobj	boundary,have
R80	T257	T255	prep	between,boundary
R81	T258	T259	amod	dorsal,hair
R82	T259	T257	pobj	hair,between
R84	T261	T259	cc	and,hair
R85	T262	T263	amod	yellow,hair
R86	T263	T259	conj	hair,hair
R88	T265	T253	punct	;,raises
R89	T266	T267	det	the,mutation
R90	T267	T253	nsubj	mutation,raises
R95	T272	T253	punct	", ",raises
R96	T273	T253	advcl	producing,raises
R97	T274	T275	det	an,transformation
R98	T275	T273	dobj	transformation,producing
R105	T282	T253	punct	.,raises
R106	T284	T285	nsubj	We,identify
R107	T286	T287	det	a,deletion
R108	T287	T285	dobj	deletion,identify
R111	T290	T287	prep	in,deletion
R112	T291	T290	pobj	deH,in
R113	T292	T293	dep	that,removes
R114	T293	T287	relcl	removes,deletion
R115	T294	T293	dobj	all,removes
R116	T295	T294	prep	but,all
R117	T296	T297	det	the,exon
R118	T297	T295	pobj	exon,but
R120	T299	T297	prep	of,exon
R121	T300	T301	det	the,gene
R122	T301	T299	pobj	gene,of
R124	T303	T297	punct	", ",exon
R125	T304	T305	poss	whose,expression
R126	T305	T307	dep	expression,correlates
R128	T307	T297	relcl	correlates,exon
R132	T311	T307	prep	with,correlates
R133	T312	T313	amod	pigmentary,malformations
R134	T313	T311	pobj	malformations,with
R137	T316	T313	acl	observed,malformations
R138	T317	T316	prep	in,observed
R139	T318	T319	compound	deH,deH
R140	T319	T321	compound	deH,animals
R142	T321	T317	pobj	animals,in
R143	T322	T285	punct	.,identify
R144	T324	T325	nsubj	Construction,confirmed
R145	T326	T324	prep	of,Construction
R146	T327	T328	det	a,allele
R147	T328	T326	pobj	allele,of
R149	T330	T328	prep	of,allele
R150	T331	T330	pobj	Tbx15,of
R151	T332	T333	mark	that,caused
R152	T333	T325	ccomp	caused,confirmed
R154	T335	T333	nsubjpass	phenotype,caused
R155	T336	T335	compound	deH,phenotype
R157	T338	T333	agent	by,caused
R158	T339	T340	compound	Tbx15,loss
R159	T340	T338	pobj	loss,by
R160	T341	T340	prep	of,loss
R161	T342	T341	pobj	function,of
R162	T343	T325	punct	.,confirmed
R163	T345	T346	advmod	Early,embryonic
R164	T346	T347	amod	embryonic,expression
R165	T347	T348	nsubj	expression,is
R166	T348	T354	ccomp	is,displaced
R172	T355	T348	acomp	complementary,is
R173	T356	T355	prep	to,complementary
R174	T357	T358	compound	Agouti,expression
R175	T358	T356	pobj	expression,to
R176	T359	T358	prep	in,expression
R177	T360	T361	amod	ventral,mesenchyme
R178	T361	T359	pobj	mesenchyme,in
R179	T362	T354	punct	;,displaced
R180	T363	T354	prep	in,displaced
R181	T364	T365	det	the,absence
R182	T365	T363	pobj	absence,in
R183	T366	T365	prep	of,absence
R184	T367	T366	pobj	Tbx15,of
R185	T368	T354	punct	", ",displaced
R186	T369	T354	nsubjpass	expression,displaced
R187	T370	T369	prep	of,expression
R188	T371	T370	pobj	Agouti,of
R189	T372	T369	prep	in,expression
R190	T373	T374	preconj	both,embryos
R191	T374	T372	pobj	embryos,in
R192	T375	T374	cc	and,embryos
R193	T376	T377	amod	postnatal,animals
R194	T377	T374	conj	animals,embryos
R195	T378	T354	auxpass	is,displaced
R196	T379	T354	advmod	dorsally,displaced
R197	T380	T354	punct	.,displaced
R198	T382	T383	compound	Transplantation,experiments
R199	T383	T384	nsubj	experiments,demonstrate
R200	T385	T386	mark	that,acquired
R201	T386	T384	ccomp	acquired,demonstrate
R211	T396	T394	pobj	differences,to
R212	T397	T396	compound	pigmentation,differences
R214	T399	T386	prep	by,acquired
R215	T400	T399	pobj	E12.5,by
R216	T401	T386	punct	", ",acquired
R217	T402	T403	dep	which,is
R218	T403	T386	advcl	is,acquired
R219	T404	T405	advmod	shortly,after
R220	T405	T403	prep	after,is
R221	T406	T407	advmod	early,embryonic
R222	T407	T408	amod	embryonic,expression
R223	T408	T405	pobj	expression,after
R224	T409	T408	prep	of,expression
R225	T410	T409	pobj	Tbx15,of
R226	T411	T384	punct	.,demonstrate
R227	T413	T414	npadvmod	Fate,mapping
R228	T414	T416	amod	mapping,studies
R230	T416	T417	nsubj	studies,show
R231	T418	T419	mark	that,is
R232	T419	T417	ccomp	is,show
R234	T421	T419	nsubj	boundary,is
R235	T422	T421	amod	dorsoventral,boundary
R236	T423	T421	compound	pigmentation,boundary
R237	T424	T419	neg	not,is
R238	T425	T419	prep	in,is
R239	T426	T425	pobj	register,in
R240	T427	T426	prep	with,register
R241	T428	T429	det	a,boundary
R242	T429	T427	pobj	boundary,with
R248	T435	T419	punct	", ",is
R249	T436	T419	cc	but,is
R250	T437	T419	conj	rather,is
R251	T438	T437	prep	with,rather
R252	T439	T440	det	the,boundary
R253	T440	T438	pobj	boundary,with
R256	T443	T417	punct	.,show
R257	T445	T446	amod	Embryonic,expression
R258	T446	T447	nsubj	expression,provides
R259	T448	T446	prep	of,expression
R260	T449	T448	pobj	Tbx15,of
R261	T450	T446	prep	in,expression
R262	T451	T452	amod	dorsolateral,mesenchyme
R263	T452	T450	pobj	mesenchyme,in
R264	T453	T454	det	an,cue
R265	T454	T447	dobj	cue,provides
R267	T456	T454	acl	required,cue
R268	T457	T458	aux	to,establish
R269	T458	T456	advcl	establish,required
R270	T459	T460	det	the,identity
R271	T460	T458	dobj	identity,establish
R274	T463	T460	prep	of,identity
R275	T464	T465	amod	dorsal,dermis
R276	T465	T463	pobj	dermis,of
R277	T466	T447	punct	.,provides
R278	T468	T469	det	These,findings
R279	T469	T470	nsubj	findings,represent
R280	T471	T472	det	a,role
R281	T472	T470	dobj	role,represent
R283	T474	T472	prep	for,role
R284	T475	T476	compound	T,box
R285	T476	T478	compound	box,action
R287	T478	T474	pobj	action,for
R289	T480	T472	prep	in,role
R290	T481	T482	amod	embryonic,development
R291	T482	T480	pobj	development,in
R292	T483	T470	punct	", ",represent
R293	T484	T470	conj	identify,represent
R294	T485	T486	det	a,aspect
R295	T486	T484	dobj	aspect,identify
R298	T489	T486	prep	of,aspect
R299	T490	T491	amod	dorsoventral,patterning
R300	T491	T489	pobj	patterning,of
R301	T492	T493	dep	that,represented
R302	T493	T486	relcl	represented,aspect
R305	T496	T493	prep	in,represented
R306	T497	T498	amod	furred,mammals
R307	T498	T496	pobj	mammals,in
R308	T499	T484	punct	", ",identify
R309	T500	T484	cc	and,identify
R310	T501	T484	conj	provide,identify
R311	T502	T501	dobj	insight,provide
R312	T503	T502	prep	into,insight
R313	T504	T505	det	the,mechanisms
R314	T505	T503	pobj	mechanisms,into
R315	T506	T507	dep	that,underlie
R316	T507	T505	relcl	underlie,mechanisms
R317	T508	T509	npadvmod	region,specific
R318	T509	T511	amod	specific,differences
R320	T511	T507	dobj	differences,underlie
R321	T512	T511	prep	in,differences
R322	T513	T514	compound	body,morphology
R323	T514	T512	pobj	morphology,in
R324	T515	T470	punct	.,represent
R325	T169	T170	amod	Dorsoventral,Patterning
R327	T993	T995	nsubj	question,is
R328	T994	T993	amod	fundamental,question
R333	T1000	T995	ccomp	acquire,is
R334	T1001	T1002	amod	adjacent,regions
R335	T1002	T1000	nsubj	regions,acquire
R336	T1003	T1002	prep	of,regions
R337	T1004	T1005	det	the,body
R339	T1006	T1005	compound	vertebrate,body
R351	T1020	T1018	dobj	plan,establish
R352	T1021	T1020	amod	general,plan
R353	T1022	T1020	compound	body,plan
R357	T1026	T1024	pobj	number,of
R358	T1027	T1028	advmod	relatively,small
R359	T1028	T1026	amod	small,number
R371	T1040	T1038	pobj	daSilva,in
R372	T1041	T1040	punct	-,daSilva
R381	T1050	T1016	conj	is,make
R382	T1051	T1052	prep	to,control
R383	T1052	T1049	relcl	control,extent
R384	T1053	T1051	pobj	which,to
R385	T1054	T1055	det	these,pathways
R386	T1055	T1052	nsubj	pathways,control
R387	T1056	T1057	amod	finer,differences
R388	T1057	T1052	dobj	differences,control
R389	T1058	T1057	prep	between,differences
R390	T1059	T1060	compound	body,regions
R391	T1060	T1058	pobj	regions,between
R437	T1110	T1104	attr	system,are
R438	T1111	T1110	amod	excellent,system
R442	T1115	T1113	ccomp	arise,investigate
R443	T1116	T1117	amod	morphological,differences
R444	T1117	T1115	nsubj	differences,arise
R466	T1140	T1146	ccomp	is,characterized
R467	T1141	T1142	amod	natural,environments
R468	T1142	T1139	pobj	environments,In
R469	T1143	T1140	punct	", ",is
R470	T1144	T1145	compound	color,variation
R471	T1145	T1140	nsubj	variation,is
R473	T1148	T1140	attr	mechanism,is
R474	T1149	T1150	advmod	nearly,universal
R475	T1150	T1148	amod	universal,mechanism
R487	T1162	T1146	nsubjpass	number,characterized
R488	T1163	T1162	amod	large,number
R496	T1171	T1169	pobj	perspective,from
R497	T1172	T1171	amod	evolutionary,perspective
R498	T1173	T1172	cc	and,evolutionary
R499	T1174	T1172	conj	ecological,evolutionary
R524	T1201	T1203	nummod	a,century
R525	T1202	T1201	quantmod	than,a
R537	T1214	T1216	nsubjpass	components,identified
R538	T1215	T1214	amod	pigmentary,components
R539	T1216	T1187	conj	identified,been
R540	T1217	T1216	aux	have,identified
R541	T1218	T1216	auxpass	been,identified
R544	T1221	T1216	ccomp	understood,identified
R545	T1222	T1221	auxpass	are,understood
R548	T1225	T1223	pobj	context,in
R549	T1226	T1225	amod	cellular,context
R550	T1227	T1226	cc	or,cellular
R551	T1228	T1229	npadvmod	organ,based
R553	T1230	T1229	punct	-,based
R587	T1268	T1266	pobj	crest,from
R588	T1269	T1268	amod	neural,crest
R631	T1314	T1312	pobj	cycle,during
R632	T1315	T1314	compound	hair,cycle
R665	T1350	T1348	advcl	shared,machinery
R666	T1351	T1350	auxpass	is,shared
R676	T1361	T1350	conj	vary,shared
R677	T1362	T1361	aux	can,vary
R705	T1392	T1389	conj	type,spotting
R706	T1393	T1392	punct	-,type
R720	T1407	T1405	pobj	components,of
R721	T1408	T1407	amod	molecular,components
R724	T1411	T1409	pobj	control,than
R725	T1412	T1411	amod	spatial,control
R726	T1413	T1412	cc	and,spatial
R727	T1414	T1412	conj	temporal,spatial
R732	T1421	T1419	pobj	aspects,of
R733	T1422	T1423	advmod	most,obvious
R734	T1423	T1421	amod	obvious,aspects
R737	T1426	T1424	pobj	variation,of
R738	T1427	T1426	compound	color,variation
R742	T1431	T1418	attr	surface,is
R743	T1432	T1431	amod	dark,surface
R744	T1433	T1431	amod	dorsal,surface
R748	T1437	T1435	pobj	surface,to
R749	T1438	T1437	amod	light,surface
R750	T1439	T1437	amod	ventral,surface
R767	T1456	T1446	relcl	is,skin
R768	T1457	T1455	pobj	which,in
R769	T1458	T1459	det	the,boundary
R770	T1459	T1456	nsubj	boundary,is
R771	T1460	T1459	prep	between,boundary
R772	T1461	T1462	amod	dorsal,compartments
R773	T1462	T1460	pobj	compartments,between
R774	T1463	T1461	cc	and,dorsal
R775	T1464	T1461	conj	ventral,dorsal
R790	T1481	T1478	conj	mammals,rodents
R791	T1482	T1481	amod	other,mammals
R794	T1485	T1477	nsubjpass	difference,brought
R795	T1486	T1485	amod	dorsoventral,difference
R813	T1504	T1502	pobj	gene,of
R814	T1505	T1504	compound	Agouti,gene
R830	T1523	T1521	pobj	cells,by
R831	T1524	T1523	compound	papilla,cells
R834	T1527	T1525	pobj	follicle,within
R835	T1528	T1527	compound	hair,follicle
R846	T1539	T1520	ccomp	switch,causes
R847	T1540	T1538	prep	in,melanocytes
R848	T1541	T1542	det	that,follicle
R849	T1542	T1540	pobj	follicle,in
R850	T1543	T1539	aux	to,switch
R856	T1549	T1551	amod	black,eumelanin
R857	T1550	T1549	punct	/,black
R861	T1554	T1556	amod	yellow,pheomelanin
R862	T1555	T1554	punct	/,yellow
R869	T1564	T1561	dobj	radius,has
R870	T1565	T1564	amod	short,radius
R881	T1576	T1561	conj	switched,has
R882	T1577	T1576	auxpass	be,switched
R888	T1583	T1581	pobj	cycle,during
R889	T1584	T1583	amod	single,cycle
R890	T1585	T1583	compound	hair,cycle
R913	T1608	T1562	nsubjpass	expression,thought
R914	T1609	T1608	amod	regulated,expression
R921	T1616	T1614	pobj	surface,for
R922	T1617	T1618	npadvmod	cream,colored
R924	T1619	T1618	punct	-,colored
R925	T1620	T1618	cc	or,colored
R926	T1621	T1618	conj	yellow,colored
R927	T1622	T1616	amod	ventral,surface
R932	T1627	T1625	dobj	allele,carrying
R933	T1628	T1627	amod	black,allele
R934	T1629	T1628	punct	-,black
R935	T1630	T1628	cc	and,black
R936	T1631	T1632	punct	-,tan
R937	T1632	T1628	conj	tan,black
R938	T1633	T1634	punct	(,at
R939	T1634	T1627	parataxis	at,allele
R940	T1635	T1634	punct	),at
R944	T1639	T1637	pobj	markings,for
R945	T1640	T1639	amod	yellow,markings
R956	T1651	T1639	appos	points,markings
R957	T1652	T1651	punct	", ",points
R958	T1653	T1651	amod	tan,points
R965	T1660	T1658	pobj	breeds,of
R966	T1661	T1660	compound	dog,breeds
R975	T1778	T1774	punct	;,Bultman
R976	T1779	T1774	nmod	Vrieling,Bultman
R977	T1780	T1774	nmod	et,Bultman
R978	T1672	T1673	poss	our,group
R979	T1781	T1774	nmod	al.,Bultman
R980	T1673	T1671	pobj	group,from
R981	T1782	T1774	nummod	1994,Bultman
R982	T1674	T1673	cc	and,group
R983	T1675	T1673	conj	others,group
R984	T1783	T1774	punct	),Bultman
R985	T1676	T1677	nummod	two,isoforms
R986	T1677	T1665	dobj	isoforms,identified
R987	T1784	T1761	cc	and,express
R988	T1678	T1677	amod	predominant,isoforms
R989	T1679	T1680	compound	Agouti,mRNA
R990	T1680	T1677	compound	mRNA,isoforms
R991	T1785	T1761	conj	have,express
R992	T1681	T1682	dep	that,differ
R993	T1682	T1677	relcl	differ,isoforms
R994	T1683	T1682	prep	by,differ
R995	T1786	T1787	amod	black,hairs
R996	T1684	T1683	pobj	virtue,by
R997	T1685	T1684	prep	of,virtue
R998	T1787	T1785	dobj	hairs,have
R999	T1686	T1687	poss	their,site
R1000	T1687	T1685	pobj	site,of
R1001	T1688	T1687	amod	transcriptional,site
R1002	T1788	T1787	amod	dorsal,hairs
R1003	T1689	T1687	compound	initiation,site
R1004	T1690	T1687	cc	and,site
R1005	T1691	T1692	nummod	5,exons
R1006	T1692	T1687	conj	exons,site
R1007	T1693	T1691	punct	′,5
R1008	T1694	T1692	amod	untranslated,exons
R1009	T1695	T1665	punct	.,identified
R1010	T1789	T1787	cc	and,hairs
R1011	T1697	T1698	det	A,transcript
R1012	T1790	T1791	npadvmod	cream,colored
R1013	T1698	T1705	nsubjpass	transcript,expressed
R1014	T1699	T1698	punct	“,transcript
R1015	T1700	T1701	compound	hair,cycle
R1016	T1701	T1702	npadvmod	cycle,specific
R1017	T1791	T1793	amod	colored,hairs
R1018	T1702	T1698	amod	specific,transcript
R1019	T1792	T1791	punct	-,colored
R1020	T1703	T1702	punct	-,specific
R1021	T1704	T1698	punct	”,transcript
R1022	T1706	T1705	auxpass	is,expressed
R1023	T1793	T1787	conj	hairs,hairs
R1024	T1707	T1705	prep	in,expressed
R1025	T1708	T1709	preconj	both,dorsal
R1026	T1794	T1791	prep	to,colored
R1027	T1709	T1710	amod	dorsal,skin
R1028	T1710	T1707	pobj	skin,in
R1029	T1711	T1709	cc	and,dorsal
R1030	T1712	T1709	conj	ventral,dorsal
R1031	T1795	T1794	amod	yellow,to
R1032	T1713	T1705	prep	for,expressed
R1033	T1714	T1715	compound	2,3
R1034	T1796	T1793	amod	ventral,hairs
R1035	T1715	T1717	nummod	3,days
R1036	T1716	T1715	punct	–,3
R1037	T1717	T1713	pobj	days,for
R1038	T1797	T1787	punct	", ",hairs
R1039	T1718	T1705	prep	during,expressed
R1040	T1719	T1720	amod	early,growth
R1041	T1720	T1718	pobj	growth,during
R1042	T1798	T1787	prep	with,hairs
R1043	T1721	T1720	compound	hair,growth
R1044	T1722	T1705	punct	", ",expressed
R1045	T1723	T1724	mark	while,expressed
R1046	T1799	T1800	det	a,boundary
R1047	T1724	T1705	advcl	expressed,expressed
R1048	T1725	T1726	det	a,transcript
R1049	T1726	T1724	nsubjpass	transcript,expressed
R1050	T1800	T1798	pobj	boundary,with
R1051	T1727	T1726	punct	“,transcript
R1052	T1728	T1729	amod	ventral,specific
R1053	T1729	T1726	amod	specific,transcript
R1054	T1801	T1800	amod	sharp,boundary
R1055	T1730	T1729	punct	-,specific
R1056	T1731	T1726	punct	”,transcript
R1057	T1732	T1724	auxpass	is,expressed
R1058	T1802	T1800	prep	at,boundary
R1059	T1733	T1724	prep	throughout,expressed
R1060	T1803	T1804	det	the,level
R1061	T1734	T1735	det	the,period
R1062	T1735	T1733	pobj	period,throughout
R1063	T1736	T1735	amod	entire,period
R1064	T1804	T1802	pobj	level,at
R1065	T1737	T1735	prep	of,period
R1066	T1738	T1739	amod	active,growth
R1067	T1739	T1737	pobj	growth,of
R1068	T1805	T1804	prep	of,level
R1069	T1740	T1739	compound	hair,growth
R1070	T1741	T1733	punct	", ",throughout
R1071	T1806	T1807	det	the,articulations
R1072	T1742	T1733	cc	but,throughout
R1073	T1807	T1805	pobj	articulations,of
R1074	T1743	T1744	advmod	only,in
R1075	T1744	T1733	conj	in,throughout
R1076	T1745	T1746	amod	ventral,skin
R1077	T1808	T1807	nmod	limb,articulations
R1078	T1746	T1744	pobj	skin,in
R1079	T1747	T1748	punct	(,Bultman
R1080	T1748	T1724	meta	Bultman,expressed
R1081	T1809	T1808	punct	–,limb
R1082	T1749	T1748	nmod	et,Bultman
R1083	T1750	T1748	nmod	al.,Bultman
R1084	T1751	T1748	nummod	1994,Bultman
R1085	T1810	T1811	compound	body,wall
R1086	T1752	T1748	punct	;,Bultman
R1087	T1753	T1748	nmod	Vrieling,Bultman
R1088	T1754	T1748	nmod	et,Bultman
R1089	T1811	T1808	appos	wall,limb
R1090	T1755	T1748	nmod	al.,Bultman
R1091	T1756	T1748	nummod	1994,Bultman
R1092	T1757	T1748	punct	),Bultman
R1093	T1812	T1802	cc	and,at
R1094	T1758	T1705	punct	.,expressed
R1095	T1813	T1802	conj	in,at
R1096	T1814	T1815	det	the,middle
R1097	T1760	T1761	nsubj	Animals,express
R1098	T1815	T1813	pobj	middle,in
R1099	T1762	T1760	acl	carrying,Animals
R1100	T1816	T1815	prep	of,middle
R1101	T1763	T1764	det	the,allele
R1102	T1764	T1762	dobj	allele,carrying
R1103	T1817	T1818	det	the,pad
R1104	T1765	T1764	compound	at,allele
R1105	T1766	T1767	advmod	only,transcript
R1106	T1767	T1761	dobj	transcript,express
R1107	T1818	T1816	pobj	pad,of
R1108	T1768	T1767	det	the,transcript
R1109	T1769	T1770	amod	ventral,specific
R1110	T1770	T1767	amod	specific,transcript
R1111	T1771	T1770	punct	-,specific
R1112	T1772	T1767	compound	Agouti,transcript
R1113	T1819	T1818	compound	whisker,pad
R1114	T1773	T1774	punct	(,Bultman
R1115	T1774	T1761	meta	Bultman,express
R1116	T1775	T1774	nmod	et,Bultman
R1117	T1776	T1774	nmod	al.,Bultman
R1118	T1820	T1761	punct	.,express
R1119	T1777	T1774	nummod	1994,Bultman
R1121	T1823	T1825	amod	specific,isoforms
R1122	T1824	T1823	punct	-,specific
R1123	T1825	T1827	nsubjpass	isoforms,expressed
R1124	T1826	T1825	compound	Agouti,isoforms
R1125	T1884	T1883	pobj	birth,after
R1126	T1828	T1827	auxpass	are,expressed
R1127	T1885	T1860	punct	.,are
R1128	T1887	T1888	det	The,boundary
R1129	T1829	T1827	advmod	also,expressed
R1130	T1888	T1889	nsubj	boundary,bears
R1131	T1890	T1888	prep	between,boundary
R1132	T1830	T1827	prep	in,expressed
R1133	T1891	T1892	amod	dorsal,compartments
R1134	T1892	T1890	pobj	compartments,between
R1135	T1831	T1832	amod	developing,skin
R1136	T1893	T1891	cc	and,dorsal
R1137	T1894	T1891	conj	ventral,dorsal
R1138	T1895	T1892	compound	color,compartments
R1139	T1896	T1888	prep	in,boundary
R1140	T1832	T1830	pobj	skin,in
R1141	T1897	T1898	compound	at,at
R1142	T1898	T1900	compound	at,mice
R1143	T1833	T1827	prep	from,expressed
R1144	T1899	T1898	punct	/,at
R1145	T1900	T1896	pobj	mice,in
R1146	T1901	T1902	amod	superficial,resemblance
R1147	T1834	T1835	amod	embryonic,day
R1148	T1902	T1889	dobj	resemblance,bears
R1149	T1835	T1833	pobj	day,from
R1150	T1903	T1902	prep	to,resemblance
R1151	T1904	T1905	amod	dorsoventral,boundaries
R1152	T1836	T1835	nummod	10.5,day
R1153	T1905	T1903	pobj	boundaries,to
R1154	T1906	T1905	amod	apparent,boundaries
R1155	T1907	T1906	prep	for,apparent
R1156	T1837	T1835	punct	(,day
R1157	T1908	T1909	amod	many,mammals
R1158	T1909	T1907	pobj	mammals,for
R1159	T1910	T1909	amod	other,mammals
R1160	T1838	T1835	appos	E10.5,day
R1161	T1911	T1889	punct	", ",bears
R1162	T1912	T1889	cc	but,bears
R1163	T1913	T1914	amod	morphogenetic,differences
R1164	T1914	T1915	nsubj	differences,seem
R1165	T1915	T1889	conj	seem,bears
R1166	T1839	T1835	punct	),day
R1167	T1916	T1914	prep	between,differences
R1168	T1840	T1833	cc	and,from
R1169	T1917	T1918	amod	dorsal,skin
R1170	T1841	T1833	conj	beyond,from
R1171	T1918	T1916	pobj	skin,between
R1172	T1919	T1917	cc	and,dorsal
R1173	T1842	T1827	cc	and,expressed
R1174	T1920	T1917	conj	ventral,dorsal
R1175	T1921	T1915	oprd	likely,seem
R1176	T1922	T1923	aux	to,include
R1177	T1843	T1844	aux	may,play
R1178	T1923	T1921	xcomp	include,likely
R1179	T1924	T1925	amod	more,elements
R1180	T1925	T1923	dobj	elements,include
R1181	T1844	T1827	conj	play,expressed
R1182	T1926	T1925	prep	than,elements
R1183	T1927	T1928	det	the,type
R1184	T1845	T1846	det	a,role
R1185	T1928	T1926	pobj	type,than
R1186	T1929	T1928	prep	of,type
R1187	T1930	T1929	pobj	pigment,of
R1188	T1846	T1844	dobj	role,play
R1189	T1931	T1930	acl	made,pigment
R1190	T1932	T1931	agent	by,made
R1191	T1933	T1934	compound	hair,follicle
R1192	T1847	T1844	prep	in,play
R1193	T1934	T1935	compound	follicle,melanocytes
R1194	T1935	T1932	pobj	melanocytes,by
R1195	T1936	T1915	punct	.,seem
R1196	T1848	T1849	compound	pigment,differentiation
R1197	T1938	T1939	prep	In,has
R1198	T1849	T1847	pobj	differentiation,in
R1199	T1939	T1946	ccomp	has,established
R1200	T1940	T1938	amod	particular,In
R1201	T1941	T1939	punct	", ",has
R1202	T1850	T1849	compound	cell,differentiation
R1203	T1942	T1939	nsubj	dermis,has
R1204	T1943	T1942	prep	of,dermis
R1205	T1944	T1945	det	the,flank
R1206	T1851	T1852	punct	(,Millar
R1207	T1945	T1943	pobj	flank,of
R1208	T1852	T1844	meta	Millar,play
R1209	T1947	T1948	advmod	at,two
R1210	T1948	T1950	nummod	two,origins
R1211	T1949	T1948	advmod	least,two
R1212	T1853	T1852	nmod	et,Millar
R1213	T1950	T1939	dobj	origins,has
R1214	T1951	T1950	amod	distinct,origins
R1215	T1952	T1950	punct	: ,origins
R1216	T1953	T1954	amod	dermatomal,derivatives
R1217	T1954	T1950	appos	derivatives,origins
R1218	T1955	T1954	prep	of,derivatives
R1219	T1854	T1852	nmod	al.,Millar
R1220	T1956	T1955	pobj	somites,of
R1221	T1957	T1954	cc	and,derivatives
R1222	T1958	T1959	amod	loose,mesenchyme
R1223	T1855	T1852	nummod	1995,Millar
R1224	T1959	T1954	conj	mesenchyme,derivatives
R1225	T1960	T1959	acl	derived,mesenchyme
R1226	T1961	T1960	prep	from,derived
R1227	T1856	T1852	punct	),Millar
R1228	T1962	T1963	det	the,mesoderm
R1229	T1963	T1961	pobj	mesoderm,from
R1230	T1857	T1827	punct	.,expressed
R1231	T1964	T1963	amod	lateral,mesoderm
R1232	T1965	T1963	compound	plate,mesoderm
R1233	T1966	T1967	punct	(,Mauger
R1234	T1859	T1860	advmod	Thus,are
R1235	T1967	T1939	meta	Mauger,has
R1236	T1968	T1967	nummod	1972,Mauger
R1237	T1969	T1967	punct	;,Mauger
R1238	T1861	T1860	punct	", ",are
R1239	T1970	T1967	nmod	Christ,Mauger
R1240	T1971	T1967	nmod	et,Mauger
R1241	T1972	T1967	nmod	al.,Mauger
R1242	T1862	T1863	amod	regulatory,elements
R1243	T1973	T1967	nummod	1983,Mauger
R1244	T1974	T1967	punct	;,Mauger
R1245	T1975	T1967	nmod	Olivera,Mauger
R1246	T1863	T1860	nsubj	elements,are
R1247	T1976	T1967	punct	-,Mauger
R1248	T1977	T1967	nmod	Martinez,Mauger
R1249	T1864	T1863	prep	for,elements
R1250	T1978	T1967	nmod	et,Mauger
R1251	T1979	T1967	nmod	al.,Mauger
R1252	T1980	T1967	nummod	2000,Mauger
R1253	T1865	T1866	amod	ventral,specific
R1254	T1981	T1967	punct	;,Mauger
R1255	T1982	T1967	nmod	Nowicki,Mauger
R1256	T1983	T1967	nmod	et,Mauger
R1257	T1866	T1868	amod	specific,isoforms
R1258	T1984	T1967	nmod	al.,Mauger
R1259	T1985	T1967	nummod	2003,Mauger
R1260	T1867	T1866	punct	-,specific
R1261	T1986	T1967	punct	),Mauger
R1262	T1868	T1864	pobj	isoforms,for
R1263	T1987	T1946	punct	;,established
R1264	T1988	T1989	det	these,lineages
R1265	T1989	T1946	nsubjpass	lineages,established
R1266	T1869	T1868	compound	Agouti,isoforms
R1267	T1870	T1860	acomp	responsive,are
R1268	T1871	T1870	prep	to,responsive
R1269	T1990	T1946	auxpass	are,established
R1270	T1991	T1992	advmod	early,in
R1271	T1872	T1873	amod	dorsoventral,cues
R1272	T1992	T1946	prep	in,established
R1273	T1993	T1992	pobj	development,in
R1274	T1994	T1946	cc	and,established
R1275	T1873	T1871	pobj	cues,to
R1276	T1995	T1996	aux	could,set
R1277	T1996	T1946	conj	set,established
R1278	T1874	T1873	amod	positional,cues
R1279	T1997	T1996	punct	", ",set
R1280	T1998	T1996	prep	in,set
R1281	T1999	T1998	amod	principle,in
R1282	T1875	T1873	acl	established,cues
R1283	T2000	T1996	punct	", ",set
R1284	T2001	T1996	prt	up,set
R1285	T2002	T1996	dobj	compartments,set
R1286	T1876	T1875	prep	in,established
R1287	T2003	T2004	poss	whose,identity
R1288	T2004	T2005	dep	identity,contributes
R1289	T2005	T2002	relcl	contributes,compartments
R1290	T1877	T1878	det	the,embryo
R1291	T2006	T2005	prep	to,contributes
R1292	T2007	T2008	amod	dorsoventral,differences
R1293	T1878	T1876	pobj	embryo,in
R1294	T2008	T2006	pobj	differences,to
R1295	T2009	T2008	prep	in,differences
R1296	T2010	T2011	amod	adult,skin
R1297	T1879	T1875	cc	and,established
R1298	T2011	T2009	pobj	skin,in
R1299	T2012	T1946	punct	.,established
R1300	T1880	T1881	poss	whose,effects
R1301	T2014	T2015	aux	To,understand
R1302	T2015	T2017	advcl	understand,determined
R1303	T1881	T1882	dep	effects,persist
R1304	T1882	T1875	conj	persist,established
R1305	T1883	T1882	prep	after,persist
R1306	T2016	T2015	advmod	better,understand
R1307	T2097	T2096	cc	and,density
R1308	T2018	T2019	det	the,mechanisms
R1309	T2019	T2015	dobj	mechanisms,understand
R1310	T2020	T2021	dep	that,give
R1311	T2098	T2097	punct	/,and
R1312	T2021	T2019	relcl	give,mechanisms
R1313	T2022	T2021	dobj	rise,give
R1314	T2023	T2021	prep	to,give
R1315	T2024	T2023	pobj	differences,to
R1316	T2099	T2097	cc	or,and
R1317	T2025	T2024	prep	between,differences
R1318	T2026	T2027	amod	dorsal,skin
R1319	T2027	T2025	pobj	skin,between
R1320	T2028	T2026	cc	and,dorsal
R1321	T2029	T2026	conj	ventral,dorsal
R1322	T2030	T2023	cc	and,to
R1323	T2100	T2096	conj	differentiation,density
R1324	T2031	T2023	conj	to,to
R1325	T2032	T2033	det	the,boundary
R1326	T2033	T2031	pobj	boundary,to
R1327	T2101	T2096	punct	", ",density
R1328	T2034	T2033	prep	between,boundary
R1329	T2035	T2034	pobj	them,between
R1330	T2036	T2017	punct	", ",determined
R1331	T2102	T2103	compound	pigment,type
R1332	T2037	T2017	nsubj	we,determined
R1333	T2038	T2017	aux	have,determined
R1334	T2103	T2105	compound	type,synthesis
R1335	T2039	T2040	advmod	how,vary
R1336	T2040	T2017	advcl	vary,determined
R1337	T2041	T2042	amod	several,characteristics
R1338	T2104	T2103	punct	-,type
R1339	T2042	T2040	nsubj	characteristics,vary
R1340	T2043	T2042	amod	morphologic,characteristics
R1341	T2044	T2040	prep	along,vary
R1342	T2105	T2096	conj	synthesis,density
R1343	T2045	T2046	det	the,axis
R1344	T2046	T2044	pobj	axis,along
R1345	T2047	T2046	amod	dorsoventral,axis
R1346	T2106	T2105	punct	", ",synthesis
R1347	T2048	T2046	prep	of,axis
R1348	T2049	T2050	det	the,mouse
R1349	T2107	T2105	cc	and,synthesis
R1350	T2050	T2048	pobj	mouse,of
R1351	T2051	T2040	cc	and,vary
R1352	T2052	T2053	advmod	how,correspond
R1353	T2108	T2109	compound	hair,length
R1354	T2053	T2040	conj	correspond,vary
R1355	T2054	T2055	det	these,characteristics
R1356	T2055	T2053	nsubj	characteristics,correspond
R1357	T2109	T2105	conj	length,synthesis
R1358	T2056	T2053	prep	to,correspond
R1359	T2057	T2058	amod	ventral,specific
R1360	T2110	T2078	punct	;,coincide
R1361	T2058	T2060	amod	specific,expression
R1362	T2059	T2058	punct	-,specific
R1363	T2060	T2056	pobj	expression,to
R1364	T2061	T2060	compound	Agouti,expression
R1365	T2111	T2078	advmod	surprisingly,coincide
R1366	T2062	T2060	cc	and,expression
R1367	T2112	T2078	punct	", ",coincide
R1368	T2063	T2064	det	the,boundary
R1369	T2064	T2060	conj	boundary,expression
R1370	T2065	T2064	compound	lineage,boundary
R1371	T2066	T2067	dep	that,distinguishes
R1372	T2067	T2064	relcl	distinguishes,boundary
R1373	T2068	T2067	dobj	somite,distinguishes
R1374	T2113	T2078	nsubj	none,coincide
R1375	T2114	T2113	prep	of,none
R1376	T2069	T2067	prep	from,distinguishes
R1377	T2070	T2071	amod	lateral,derivatives
R1378	T2071	T2069	pobj	derivatives,from
R1379	T2072	T2071	compound	plate,derivatives
R1380	T2115	T2114	pobj	these,of
R1381	T2073	T2017	punct	.,determined
R1382	T2075	T2076	poss	Our,results
R1383	T2116	T2078	prep	with,coincide
R1384	T2076	T2077	nsubj	results,indicate
R1385	T2077	T2078	ccomp	indicate,coincide
R1386	T2117	T2118	det	the,boundary
R1387	T2079	T2080	mark	that,represents
R1388	T2080	T2077	ccomp	represents,indicate
R1389	T2118	T2116	pobj	boundary,with
R1390	T2081	T2082	det	the,uniformity
R1391	T2082	T2080	nsubj	uniformity,represents
R1392	T2119	T2120	npadvmod	somite,lateral
R1393	T2083	T2082	amod	apparent,uniformity
R1394	T2084	T2082	prep	of,uniformity
R1395	T2085	T2086	det	the,boundary
R1396	T2120	T2118	amod	lateral,boundary
R1397	T2086	T2084	pobj	boundary,of
R1398	T2087	T2086	amod	dorsoventral,boundary
R1399	T2088	T2089	det	the,sum
R1400	T2121	T2120	punct	–,lateral
R1401	T2089	T2080	dobj	sum,represents
R1402	T2090	T2089	prep	of,sum
R1403	T2091	T2092	amod	independent,mechanisms
R1404	T2122	T2123	compound	plate,lineage
R1405	T2092	T2090	pobj	mechanisms,of
R1406	T2093	T2094	dep	that,affect
R1407	T2094	T2092	relcl	affect,mechanisms
R1408	T2123	T2118	compound	lineage,boundary
R1409	T2095	T2096	compound	melanocyte,density
R1410	T2124	T2078	punct	.,coincide
R1411	T2096	T2094	dobj	density,affect
R1417	T2132	T2130	pobj	mutation,of
R1418	T2133	T2132	amod	classical,mutation
R1419	T2203	T2204	det	a,manner
R1420	T2134	T2132	compound	mouse,mutation
R1421	T2204	T2202	pobj	manner,in
R1422	T2205	T2204	amod	dynamic,manner
R1423	T2206	T2205	cc	and,dynamic
R1424	T2207	T2208	advmod	spatially,restricted
R1425	T2208	T2205	conj	restricted,dynamic
R1426	T2209	T2201	prep	in,expressed
R1427	T2135	T2132	punct	", ",mutation
R1428	T2210	T2211	det	the,skin
R1429	T2211	T2209	pobj	skin,in
R1430	T2212	T2211	amod	developing,skin
R1431	T2136	T2137	amod	droopy,ear
R1432	T2213	T2211	cc	and,skin
R1433	T2214	T2215	amod	musculoskeletal,system
R1434	T2215	T2211	conj	system,skin
R1435	T2137	T2132	appos	ear,mutation
R1436	T2216	T2169	punct	.,identify
R1437	T2138	T2139	punct	(,Curry
R1438	T2218	T2219	amod	Embryonic,studies
R1439	T2219	T2223	nsubj	studies,suggest
R1440	T2220	T2219	nmod	expression,studies
R1441	T2139	T2132	meta	Curry,mutation
R1442	T2221	T2220	cc	and,expression
R1443	T2222	T2220	conj	transplantation,expression
R1444	T2140	T2139	nummod	1959,Curry
R1445	T2224	T2225	mark	that,required
R1446	T2225	T2223	ccomp	required,suggest
R1447	T2226	T2225	nsubjpass	Tbx15,required
R1448	T2141	T2139	punct	),Curry
R1449	T2227	T2225	auxpass	is,required
R1450	T2228	T2229	aux	to,establish
R1451	T2229	T2225	xcomp	establish,required
R1452	T2142	T2132	punct	", ",mutation
R1453	T2230	T2231	amod	certain,characteristics
R1454	T2231	T2229	dobj	characteristics,establish
R1455	T2232	T2231	prep	of,characteristics
R1456	T2233	T2234	amod	dorsal,patterning
R1457	T2143	T2144	dep	that,produces
R1458	T2234	T2232	pobj	patterning,of
R1459	T2235	T2229	prep	in,establish
R1460	T2144	T2132	relcl	produces,mutation
R1461	T2236	T2237	amod	mesenchymal,cells
R1462	T2237	T2235	pobj	cells,in
R1463	T2238	T2237	prep	of,cells
R1464	T2145	T2146	det	a,transformation
R1465	T2146	T2144	dobj	transformation,produces
R1466	T2147	T2146	amod	dorsal,transformation
R1469	T2148	T2147	punct	-,dorsal
R1472	T2149	T2147	prep	to,dorsal
R1476	T2150	T2149	punct	-,to
R1480	T2151	T2149	amod	ventral,to
R1485	T2152	T2146	prep	of,transformation
R1489	T2153	T2154	compound	flank,color
R1492	T2154	T2152	pobj	color,of
R1497	T2155	T2154	compound	coat,color
R1501	T2156	T2144	prep	by,produces
R1505	T2157	T2156	pcomp	allowing,by
R1509	T2158	T2157	dobj	expansion,allowing
R1512	T2159	T2158	prep	of,expansion
R1515	T2160	T2161	det	the,transcript
R1516	T2161	T2159	pobj	transcript,of
R1517	T2162	T2163	amod	ventral,specific
R1518	T2163	T2161	amod	specific,transcript
R1519	T2164	T2163	punct	-,specific
R1520	T2165	T2161	compound	Agouti,transcript
R1521	T2166	T2127	punct	.,make
R1522	T2168	T2169	prep	By,identify
R1523	T2170	T2171	amod	positional,cloning
R1524	T2171	T2168	pobj	cloning,By
R1525	T2172	T2171	cc	and,cloning
R1526	T2173	T2174	compound	gene,targeting
R1527	T2174	T2171	conj	targeting,cloning
R1528	T2175	T2169	punct	", ",identify
R1529	T2176	T2169	nsubj	we,identify
R1530	T2177	T2178	det	an,allele
R1531	T2178	T2169	dobj	allele,identify
R1532	T2179	T2178	prep	of,allele
R1533	T2180	T2181	amod	droopy,ear
R1534	T2181	T2179	pobj	ear,of
R1535	T2182	T2178	punct	", ",allele
R1536	T2183	T2178	appos	deH,allele
R1537	T2184	T2169	punct	", ",identify
R1538	T2185	T2169	prep	as,identify
R1539	T2186	T2187	det	a,loss
R1540	T2187	T2185	pobj	loss,as
R1541	T2188	T2187	prep	of,loss
R1542	T2189	T2188	pobj	function,of
R1543	T2190	T2187	prep	for,loss
R1544	T2191	T2190	pobj	Tbx15,for
R1545	T2192	T2191	punct	", ",Tbx15
R1546	T2193	T2194	dep	which,encodes
R1547	T2194	T2191	relcl	encodes,Tbx15
R1548	T2195	T2196	det	a,factor
R1549	T2196	T2194	dobj	factor,encodes
R1550	T2197	T2198	compound	T,box
R1551	T2198	T2196	compound	box,factor
R1552	T2199	T2198	punct	-,box
R1553	T2200	T2196	compound	transcription,factor
R1554	T2201	T2196	acl	expressed,factor
R1555	T2202	T2201	prep	in,expressed
R1559	T2551	T2549	pobj	Differences,of
R1560	T2552	T2551	compound	Skin,Differences
R1563	T2557	T2554	pobj	change,Besides
R1564	T2558	T2557	amod	obvious,change
R1569	T2563	T2557	relcl	distinguishes,change
R1570	T2564	T2563	advmod	frequently,distinguishes
R1616	T2612	T2601	cc	as,number
R1617	T2613	T2612	advmod	well,as
R1637	T2635	T2637	compound	at,animals
R1638	T2636	T2635	punct	/,at
R1643	T2641	T2639	amod	colored,from
R1644	T2642	T2641	punct	-,colored
R1647	T2645	T2643	amod	yellow,to
R1648	T2646	T2645	punct	-,yellow
R1660	T2658	T2656	pobj	axis,along
R1661	T2659	T2658	amod	dorsoventral,axis
R1678	T2678	T2676	pobj	genotypes,of
R1679	T2679	T2678	compound	Agouti,genotypes
R1694	T2696	T2684	ccomp	coincides,reveal
R1695	T2697	T2698	det	the,boundary
R1696	T2698	T2696	nsubj	boundary,coincides
R1697	T2699	T2698	amod	apparent,boundary
R1698	T2700	T2698	amod	sharp,boundary
R1699	T2701	T2698	prep	between,boundary
R1700	T2702	T2703	amod	dorsal,compartments
R1701	T2703	T2701	pobj	compartments,between
R1702	T2704	T2702	cc	and,dorsal
R1703	T2705	T2702	conj	ventral,dorsal
R1704	T2706	T2703	compound	pigment,compartments
R1705	T2707	T2698	prep	in,boundary
R1706	T2708	T2709	compound	at,at
R1708	T2710	T2709	punct	/,at
R1709	T2711	T2707	pobj	mice,in
R1712	T2714	T2712	pobj	change,with
R1713	T2715	T2716	advmod	more,gradual
R1714	T2716	T2714	amod	gradual,change
R1717	T2719	T2717	pobj	color,in
R1718	T2720	T2719	compound	hair,color
R1723	T2725	T2696	parataxis	1A,coincides
R1724	T2726	T2725	nmod	Figure,1A
R1747	T2751	T2753	compound	at,mice
R1748	T2752	T2751	punct	/,at
R1792	T2799	T2804	advcl	varies,are
R1793	T2800	T2801	compound	hair,cycle
R1795	T2802	T2801	punct	-,cycle
R1796	T2803	T2799	nsubj	timing,varies
R1799	T2807	T2805	pobj	axis,along
R1800	T2808	T2807	amod	rostrocaudal,axis
R1805	T2813	T2811	pobj	length,of
R1806	T2814	T2813	compound	hair,length
R1827	T2837	T2835	pobj	length,of
R1828	T2838	T2837	compound	hair,length
R1859	T2871	T2865	ccomp	stereotyped,indicate
R1860	T2872	T2871	nsubj	variation,stereotyped
R1861	T2873	T2872	prep	of,variation
R1862	T2874	T2875	compound	hair,length
R1863	T2875	T2873	pobj	length,of
R1864	T2876	T2872	prep	along,variation
R1865	T2877	T2878	det	the,axis
R1867	T2879	T2878	amod	dorsoventral,axis
R1868	T2880	T2871	aux	is,stereotyped
R1873	T2885	T2883	pobj	cycles,through
R1874	T2886	T2885	compound	hair,cycles
R1888	T2900	T2898	dobj	transition,encompasses
R1889	T2901	T2902	compound	pigment,type
R1891	T2903	T2902	punct	-,type
R1894	T2906	T2908	compound	at,mice
R1895	T2907	T2906	punct	/,at
R1899	T2912	T2915	nsubj	skin,develop
R1900	T2913	T2911	cc	and,Dorsal
R1901	T2914	T2911	conj	ventral,Dorsal
R1918	T2934	T2923	dobj	follicles,exhibit
R1919	T2935	T2934	compound	hair,follicles
R1923	T2939	T2937	acomp	developed,are
R1924	T2940	T2939	advmod	more,developed
R1927	T2943	T2941	pobj	follicles,than
R1928	T2944	T2943	compound	hair,follicles
R1933	T2949	T2947	pobj	decrease,with
R1934	T2950	T2949	amod	gradual,decrease
R1935	T2951	T2949	amod	dorsoventral,decrease
R1952	T2970	T2972	nummod	4,wk
R1953	T2971	T2970	punct	–,4
R1967	T2985	T2962	conj	is,disappear
R1968	T2986	T2985	punct	", ",is
R1969	T2987	T2988	det	the,proportion
R1970	T2988	T2985	nsubj	proportion,is
R1971	T2989	T2988	prep	of,proportion
R1972	T2990	T2991	amod	different,types
R1974	T2992	T2991	compound	hair,types
R1987	T3007	T3009	amod	matched,mice
R1988	T3008	T3007	punct	-,matched
R1989	T3009	T3004	pobj	mice,In
R1990	T3010	T3009	amod	inbred,mice
R1994	T3014	T3005	dobj	decrease,observed
R1995	T3015	T3014	amod	small,decrease
R2031	T3051	T3049	attr	difference,was
R2032	T3052	T3051	amod	consistent,difference
R2035	T3055	T3057	compound	type,distribution
R2036	T3056	T3055	punct	-,type
R2042	T3062	T3049	parataxis	shown,was
R2043	T3063	T3062	nsubj	data,shown
R2044	T3064	T3062	neg	not,shown
R2050	T3072	T3070	pobj	pigmentation,between
R2051	T3073	T3071	cc	and,dorsal
R2052	T3074	T3071	conj	ventral,dorsal
R2055	T3077	T3079	compound	at,mice
R2056	T3078	T3077	punct	/,at
R2062	T3084	T3086	compound	type,differences
R2063	T3085	T3084	punct	-,type
R2068	T3090	T3092	amod	specific,expression
R2069	T3091	T3090	punct	-,specific
R2076	T3098	T3069	conj	have,attributed
R2077	T3099	T3097	amod	homozygous,animals
R2078	T3100	T3099	prep	for,homozygous
R2079	T3101	T3102	det	a,allele
R2081	T3103	T3102	amod	null,allele
R2082	T3104	T3102	prep	of,allele
R2083	T3105	T3104	pobj	Agouti,of
R2084	T3106	T3102	punct	", ",allele
R2085	T3107	T3108	amod	extreme,nonagouti
R2086	T3108	T3102	appos	nonagouti,allele
R2087	T3109	T3108	punct	(,nonagouti
R2088	T3110	T3108	appos	ae,nonagouti
R2089	T3111	T3108	punct	),nonagouti
R2090	T3112	T3098	punct	", ",have
R2103	T3125	T3123	dobj	appearance,giving
R2104	T3126	T3127	advmod	slightly,paler
R2105	T3127	T3125	amod	paler,appearance
R2108	T3130	T3128	pobj	coat,to
R2109	T3131	T3130	amod	ventral,coat
R2127	T3151	T3139	dobj	transition,observed
R2128	T3152	T3151	amod	gradual,transition
R2129	T3153	T3151	amod	dorsoventral,transition
R2132	T3156	T3154	pobj	preparations,in
R2133	T3157	T3156	compound	dermis,preparations
R2136	T3160	T3158	pobj	mice,from
R2137	T3161	T3162	compound	ae,ae
R2139	T3163	T3162	punct	/,ae
R2151	T3177	T3179	compound	at,mice
R2152	T3178	T3177	punct	/,at
R2155	T3181	T3171	dobj	transition,reveal
R2156	T3182	T3181	amod	abrupt,transition
R2157	T3183	T3181	amod	dorsoventral,transition
R2163	T3189	T3181	relcl	reflects,transition
R2164	T3190	T3189	advmod	probably,reflects
R2166	T3192	T3189	dobj	effects,reflects
R2167	T3193	T3192	amod	additive,effects
R2170	T3196	T3194	pobj	content,of
R2171	T3197	T3196	compound	melanin,content
R2176	T3202	T3204	compound	ae,mice
R2177	T3203	T3202	punct	/,ae
R2196	T3224	T3222	xcomp	influenced,likely
R2197	T3225	T3224	auxpass	be,influenced
R2207	T3235	T3229	conj	environment,number
R2208	T3236	T3235	amod	follicular,environment
R2216	T3246	T3244	pobj	content,in
R2217	T3247	T3246	compound	pigment,content
R2220	T3250	T3252	compound	ae,mice
R2221	T3251	T3250	punct	/,ae
R2225	T3255	T3253	pobj	cycles,throughout
R2226	T3256	T3255	compound	hair,cycles
R2244	T3276	T3278	nummod	three,characteristics
R2245	T3277	T3276	advmod	least,three
R2255	T3287	T3289	compound	type,synthesis
R2256	T3288	T3287	punct	-,type
R2278	T3536	T3535	prep	of,Ventralization
R2279	T3537	T3538	compound	Skin,Morphology
R2280	T3538	T3536	pobj	Morphology,of
R2281	T3539	T3535	prep	by,Ventralization
R2282	T3540	T3541	det	the,Mutation
R2284	T3542	T3543	amod	droopy,ear
R2285	T3543	T3541	compound	ear,Mutation
R2286	T3545	T3546	advcl	Named,is
R2287	T3546	T3556	ccomp	is,is
R2288	T3547	T3545	prep	after,Named
R2289	T3548	T3549	poss	its,effects
R2290	T3549	T3547	pobj	effects,after
R2291	T3550	T3549	prep	on,effects
R2292	T3551	T3552	amod	craniofacial,morphology
R2293	T3552	T3550	pobj	morphology,on
R2294	T3553	T3546	punct	", ",is
R2295	T3554	T3555	amod	droopy,ear
R2296	T3555	T3546	nsubj	ear,is
R2297	T3557	T3558	det	a,mutation
R2298	T3558	T3546	attr	mutation,is
R2299	T3559	T3558	amod	recessive,mutation
R2300	T3560	T3558	prep	on,mutation
R2301	T3561	T3562	compound	mouse,Chromosome
R2302	T3562	T3560	pobj	Chromosome,on
R2303	T3563	T3562	nummod	3,Chromosome
R2304	T3564	T3556	punct	;,is
R2305	T3565	T3566	det	the,allele
R2306	T3566	T3556	nsubj	allele,is
R2307	T3567	T3566	amod	original,allele
R2308	T3568	T3566	acl	described,allele
R2309	T3569	T3570	amod	more,40
R2310	T3570	T3572	nummod	40,years
R2311	T3571	T3570	quantmod	than,40
R2312	T3572	T3573	npadvmod	years,ago
R2313	T3573	T3568	advmod	ago,described
R2314	T3574	T3568	agent	by,described
R2315	T3575	T3574	pobj	Curry,by
R2316	T3576	T3577	punct	(,1959
R2317	T3577	T3568	parataxis	1959,described
R2318	T3578	T3577	punct	),1959
R2319	T3579	T3556	acomp	extinct,is
R2320	T3580	T3556	punct	", ",is
R2321	T3581	T3556	cc	but,is
R2322	T3582	T3583	det	a,remutation
R2323	T3583	T3585	nsubj	remutation,is
R2324	T3584	T3583	amod	spontaneous,remutation
R2325	T3585	T3556	conj	is,is
R2326	T3586	T3587	dep	that,occurred
R2327	T3587	T3583	relcl	occurred,remutation
R2328	T3588	T3587	prep	in,occurred
R2329	T3589	T3588	pobj	Harwell,in
R2330	T3590	T3583	punct	", ",remutation
R2331	T3591	T3583	appos	deH,remutation
R2332	T3592	T3585	punct	", ",is
R2333	T3593	T3585	acomp	available,is
R2334	T3594	T3585	prep	through,is
R2335	T3595	T3596	det	The,Laboratory
R2336	T3596	T3594	pobj	Laboratory,through
R2337	T3597	T3596	compound	Jackson,Laboratory
R2338	T3598	T3599	punct	(,Harbor
R2339	T3599	T3585	parataxis	Harbor,is
R2340	T3600	T3599	compound	Bar,Harbor
R2341	T3601	T3599	punct	", ",Harbor
R2342	T3602	T3599	npadvmod	Maine,Harbor
R2343	T3603	T3599	punct	", ",Harbor
R2344	T3604	T3605	compound	United,States
R2345	T3605	T3599	npadvmod	States,Harbor
R2346	T3606	T3599	punct	),Harbor
R2347	T3607	T3556	punct	.,is
R2348	T3609	T3610	amod	External,malformations
R2349	T3610	T3612	nsubj	malformations,are
R2350	T3611	T3610	amod	craniofacial,malformations
R2351	T3613	T3614	det	the,characteristic
R2353	T3615	T3616	advmod	most,obvious
R2354	T3616	T3614	amod	obvious,characteristic
R2355	T3617	T3614	prep	of,characteristic
R2356	T3618	T3619	compound	deH,deH
R2357	T3619	T3621	compound	deH,animals
R2358	T3620	T3619	punct	/,deH
R2359	T3621	T3617	pobj	animals,of
R2360	T3622	T3612	punct	", ",are
R2361	T3623	T3612	prep	including,are
R2362	T3624	T3625	advmod	widely,spaced
R2363	T3625	T3626	amod	spaced,eyes
R2364	T3626	T3623	pobj	eyes,including
R2365	T3627	T3626	punct	", ",eyes
R2366	T3628	T3629	amod	small,fissures
R2367	T3629	T3626	conj	fissures,eyes
R2368	T3630	T3629	amod	palpebral,fissures
R2369	T3631	T3629	punct	", ",fissures
R2370	T3632	T3633	det	a,area
R2372	T3634	T3633	amod	broad,area
R2373	T3635	T3633	amod	nasal,area
R2374	T3636	T3633	punct	", ",area
R2375	T3637	T3633	cc	and,area
R2376	T3638	T3639	det	a,skull
R2377	T3639	T3633	conj	skull,area
R2378	T3640	T3639	amod	shortened,skull
R2379	T3641	T3639	acl	held,skull
R2380	T3642	T3641	prep	in,held
R2381	T3643	T3644	det	an,position
R2382	T3644	T3642	pobj	position,in
R2383	T3645	T3644	amod	elevated,position
R2384	T3646	T3639	punct	", ",skull
R2385	T3647	T3648	dep	which,causes
R2386	T3648	T3639	relcl	causes,skull
R2387	T3649	T3648	advmod	presumably,causes
R2388	T3650	T3648	cc	or,causes
R2389	T3651	T3648	conj	contributes,causes
R2390	T3652	T3651	prep	to,contributes
R2391	T3653	T3654	det	the,position
R2392	T3654	T3651	dobj	position,contributes
R2393	T3655	T3654	amod	abnormal,position
R2394	T3656	T3654	prep	of,position
R2395	T3657	T3658	det	the,ears
R2396	T3658	T3656	pobj	ears,of
R2397	T3659	T3612	punct	.,are
R2398	T3661	T3662	nsubj	We,became
R2399	T3662	T3663	ccomp	became,comes
R2400	T3664	T3662	acomp	interested,became
R2401	T3665	T3664	prep	in,interested
R2402	T3666	T3667	amod	droopy,ear
R2403	T3667	T3665	pobj	ear,in
R2404	T3668	T3669	mark	because,described
R2405	T3669	T3662	advcl	described,became
R2406	T3670	T3671	det	the,allele
R2407	T3671	T3669	nsubjpass	allele,described
R2408	T3672	T3671	amod	original,allele
R2409	T3673	T3669	auxpass	was,described
R2410	T3674	T3675	aux	to,affect
R2411	T3675	T3669	xcomp	affect,described
R2412	T3676	T3677	compound	pigment,pattern
R2413	T3677	T3675	dobj	pattern,affect
R2414	T3678	T3675	prep	in,affect
R2415	T3679	T3680	det	a,way
R2416	T3680	T3678	pobj	way,in
R2417	T3681	T3682	dep	that,suggests
R2418	T3682	T3680	relcl	suggests,way
R2419	T3683	T3684	det	a,transformation
R2420	T3684	T3682	dobj	transformation,suggests
R2421	T3685	T3684	amod	possible,transformation
R2422	T3686	T3684	amod	dorsal,transformation
R2423	T3687	T3686	prep	to,dorsal
R2424	T3688	T3687	amod	ventral,to
R2425	T3689	T3663	punct	: ,comes
R2426	T3690	T3663	punct	“,comes
R2427	T3691	T3663	prep	On,comes
R2428	T3692	T3693	det	a,background
R2429	T3693	T3691	pobj	background,On
R2430	T3694	T3693	amod	genetic,background
R2431	T3695	T3693	punct	(,background
R2432	T3696	T3693	appos	at,background
R2433	T3697	T3696	cc	and,at
R2434	T3698	T3696	conj	AW,at
R2435	T3699	T3693	punct	),background
R2436	T3700	T3701	dep	which,causes
R2437	T3701	T3693	relcl	causes,background
R2438	T3702	T3703	det	the,hair
R2439	T3703	T3705	nsubj	hair,be
R2440	T3704	T3703	compound	belly,hair
R2441	T3705	T3701	ccomp	be,causes
R2442	T3706	T3705	aux	to,be
R2443	T3707	T3705	acomp	lighter,be
R2444	T3708	T3707	prep	than,lighter
R2445	T3709	T3710	det	the,hair
R2446	T3710	T3708	pobj	hair,than
R2447	T3711	T3710	compound	back,hair
R2448	T3712	T3663	punct	", ",comes
R2449	T3713	T3714	det	the,hair
R2450	T3714	T3663	nsubj	hair,comes
R2451	T3715	T3714	compound	belly,hair
R2452	T3716	T3663	prt	up,comes
R2453	T3717	T3663	advmod	farther,comes
R2454	T3718	T3663	prep	round,comes
R2455	T3719	T3720	det	the,sides
R2456	T3720	T3718	pobj	sides,round
R2457	T3721	T3720	prep	of,sides
R2458	T3722	T3723	det	the,body
R2459	T3723	T3721	pobj	body,of
R2460	T3724	T3723	cc	and,body
R2461	T3725	T3723	conj	face,body
R2462	T3726	T3663	punct	”,comes
R2463	T3727	T3728	punct	(,Curry
R2464	T3728	T3663	meta	Curry,comes
R2465	T3729	T3728	nummod	1959,Curry
R2466	T3730	T3728	punct	),Curry
R2467	T3731	T3663	punct	.,comes
R2468	T3733	T3734	det	An,pattern
R2469	T3734	T3738	nsubj	pattern,is
R2470	T3735	T3734	amod	abnormal,pattern
R2471	T3736	T3734	amod	dorsoventral,pattern
R2472	T3737	T3734	compound	pigment,pattern
R2473	T3739	T3740	advmod	readily,apparent
R2474	T3740	T3738	acomp	apparent,is
R2475	T3741	T3738	prep	in,is
R2476	T3742	T3743	nmod	at,at
R2477	T3743	T3745	nmod	at,mice
R2478	T3744	T3743	punct	/,at
R2479	T3745	T3741	pobj	mice,in
R2480	T3746	T3743	punct	;,at
R2481	T3747	T3748	compound	deH,deH
R2482	T3748	T3743	appos	deH,at
R2483	T3749	T3748	punct	/,deH
R2484	T3750	T3738	punct	", ",is
R2485	T3751	T3738	cc	but,is
R2486	T3752	T3753	nsubjpass	comparison,described
R2487	T3753	T3738	conj	described,is
R2488	T3754	T3752	prep	to,comparison
R2489	T3755	T3756	amod	nonmutant,animals
R2490	T3756	T3754	pobj	animals,to
R2491	T3757	T3753	auxpass	is,described
R2492	T3758	T3759	advmod	more,accurately
R2493	T3759	T3753	advmod	accurately,described
R2494	T3760	T3753	prep	in,described
R2495	T3761	T3760	pobj	terms,in
R2496	T3762	T3761	prep	of,terms
R2497	T3763	T3764	amod	ventral,regions
R2498	T3764	T3762	pobj	regions,of
R2499	T3765	T3763	punct	", ",ventral
R2500	T3766	T3763	conj	lateral,ventral
R2501	T3767	T3766	punct	", ",lateral
R2502	T3768	T3766	cc	and,lateral
R2503	T3769	T3766	conj	dorsal,lateral
R2504	T3770	T3771	punct	(,1G
R2505	T3771	T3753	parataxis	1G,described
R2506	T3772	T3771	nmod	Figures,1G
R2507	T3773	T3771	cc	and,1G
R2508	T3774	T3771	conj	2A,1G
R2509	T3775	T3771	punct	),1G
R2510	T3776	T3753	punct	.,described
R2511	T3778	T3779	det	The,region
R2512	T3779	T3781	nsubj	region,has
R2513	T3780	T3779	amod	ventral,region
R2514	T3781	T3782	ccomp	has,are
R2515	T3783	T3784	amod	short,hairs
R2516	T3784	T3781	dobj	hairs,has
R2517	T3785	T3784	prep	with,hairs
R2518	T3786	T3787	det	a,base
R2519	T3787	T3785	pobj	base,with
R2520	T3788	T3787	amod	gray,base
R2521	T3789	T3787	cc	and,base
R2522	T3790	T3791	npadvmod	cream,colored
R2523	T3791	T3793	amod	colored,tip
R2524	T3792	T3791	punct	-,colored
R2525	T3793	T3787	conj	tip,base
R2526	T3794	T3795	poss	whose,boundary
R2527	T3795	T3796	dep	boundary,coincides
R2528	T3796	T3784	relcl	coincides,hairs
R2529	T3797	T3796	prep	with,coincides
R2530	T3798	T3799	det	the,junction
R2531	T3799	T3797	pobj	junction,with
R2532	T3800	T3801	compound	limb,body
R2533	T3801	T3799	compound	body,junction
R2534	T3802	T3801	punct	–,body
R2535	T3803	T3799	compound	wall,junction
R2536	T3804	T3782	punct	;,are
R2537	T3805	T3806	preconj	both,appearance
R2538	T3806	T3782	nsubj	appearance,are
R2539	T3807	T3806	det	the,appearance
R2540	T3808	T3806	prep	of,appearance
R2541	T3809	T3810	det	this,region
R2542	T3810	T3808	pobj	region,of
R2543	T3811	T3806	cc	and,appearance
R2544	T3812	T3806	conj	position,appearance
R2545	T3813	T3812	prep	of,position
R2546	T3814	T3815	det	the,boundary
R2547	T3815	T3813	pobj	boundary,of
R2548	T3816	T3817	advmod	approximately,similar
R2549	T3817	T3782	acomp	similar,are
R2550	T3818	T3782	prep	in,are
R2551	T3819	T3820	nmod	at,at
R2552	T3820	T3822	nmod	at,mice
R2553	T3821	T3820	punct	/,at
R2554	T3822	T3818	pobj	mice,in
R2555	T3823	T3820	prep	compared,at
R2556	T3824	T3823	prep	to,compared
R2557	T3825	T3826	compound	at,at
R2558	T3826	T3824	pobj	at,to
R2559	T3827	T3826	punct	/,at
R2560	T3828	T3826	punct	;,at
R2561	T3829	T3830	compound	deH,deH
R2562	T3830	T3826	appos	deH,at
R2563	T3831	T3830	punct	/,deH
R2564	T3832	T3782	punct	.,are
R2565	T3834	T3835	det	The,region
R2566	T3835	T3837	nsubj	region,contains
R2567	T3836	T3835	amod	lateral,region
R2568	T3837	T3838	ccomp	contains,appears
R2569	T3839	T3840	amod	yellow,hairs
R2570	T3840	T3837	dobj	hairs,contains
R2571	T3841	T3840	prep	of,hairs
R2572	T3842	T3843	advmod	progressively,increasing
R2573	T3843	T3844	amod	increasing,length
R2574	T3844	T3841	pobj	length,of
R2575	T3845	T3838	punct	;,appears
R2576	T3846	T3838	prep	in,appears
R2577	T3847	T3848	compound	at,at
R2578	T3848	T3850	compound	at,mice
R2579	T3849	T3848	punct	/,at
R2580	T3850	T3846	pobj	mice,in
R2581	T3851	T3838	punct	", ",appears
R2582	T3852	T3853	det	the,region
R2583	T3853	T3838	nsubj	region,appears
R2584	T3854	T3853	amod	lateral,region
R2585	T3855	T3838	prep	as,appears
R2586	T3856	T3857	det	a,stripe
R2588	T3858	T3857	amod	thin,stripe
R2589	T3859	T3857	amod	yellow,stripe
R2590	T3860	T3838	prep	along,appears
R2591	T3861	T3862	det	the,flank
R2592	T3862	T3860	pobj	flank,along
R2593	T3863	T3838	punct	", ",appears
R2594	T3864	T3838	cc	but,appears
R2595	T3865	T3866	prep	in,is
R2596	T3866	T3838	conj	is,appears
R2597	T3867	T3868	nmod	at,at
R2598	T3868	T3870	nmod	at,mice
R2599	T3869	T3868	punct	/,at
R2600	T3870	T3865	pobj	mice,in
R2601	T3871	T3868	punct	;,at
R2602	T3872	T3873	compound	deH,deH
R2603	T3873	T3868	appos	deH,at
R2604	T3874	T3873	punct	/,deH
R2605	T3875	T3866	punct	", ",is
R2606	T3876	T3877	det	the,region
R2607	T3877	T3866	nsubj	region,is
R2608	T3878	T3877	amod	lateral,region
R2609	T3879	T3880	advmod	considerably,expanded
R2610	T3880	T3866	acomp	expanded,is
R2611	T3881	T3866	prep	with,is
R2612	T3882	T3883	det	a,boundary
R2613	T3883	T3881	pobj	boundary,with
R2614	T3884	T3883	amod	diffuse,boundary
R2615	T3885	T3883	prep	along,boundary
R2616	T3886	T3887	det	the,flank
R2617	T3887	T3885	pobj	flank,along
R2618	T3888	T3887	amod	dorsal,flank
R2619	T3889	T3883	punct	", ",boundary
R2620	T3890	T3883	cc	and,boundary
R2621	T3891	T3892	det	a,region
R2623	T3893	T3892	amod	dorsal,region
R2624	T3894	T3892	amod	eumelanic,region
R2625	T3895	T3896	poss	whose,size
R2626	T3896	T3897	dep	size,reduced
R2628	T3898	T3897	auxpass	is,reduced
R2629	T3899	T3897	advmod	correspondingly,reduced
R2630	T3900	T3901	punct	(,2A
R2631	T3901	T3866	parataxis	2A,is
R2632	T3902	T3901	nmod	Figure,2A
R2633	T3903	T3901	cc	and,2A
R2634	T3904	T3901	conj	2B,2A
R2635	T3905	T3901	punct	),2A
R2636	T3906	T3838	punct	.,appears
R2637	T3908	T3909	amod	Total,size
R2638	T3909	T3911	nsubj	size,is
R2639	T3910	T3909	compound	body,size
R2640	T3912	T3911	acomp	smaller,is
R2641	T3913	T3911	prep	in,is
R2642	T3914	T3913	pobj	mutant,in
R2643	T3915	T3914	prep	compared,mutant
R2644	T3916	T3915	prep	to,compared
R2645	T3917	T3916	pobj	nonmutant,to
R2646	T3918	T3914	appos	animals,mutant
R2647	T3919	T3911	punct	", ",is
R2648	T3920	T3911	cc	but,is
R2649	T3921	T3922	det	the,proportion
R2650	T3922	T3923	nsubjpass	proportion,increased
R2651	T3923	T3911	conj	increased,is
R2652	T3924	T3922	prep	of,proportion
R2653	T3925	T3926	compound	body,circumference
R2654	T3926	T3924	pobj	circumference,of
R2655	T3927	T3922	acl	occupied,proportion
R2656	T3928	T3927	agent	by,occupied
R2657	T3929	T3930	det	the,region
R2658	T3930	T3928	pobj	region,by
R2659	T3931	T3930	amod	lateral,region
R2660	T3932	T3927	prep	in,occupied
R2661	T3933	T3934	amod	mutant,animals
R2662	T3934	T3932	pobj	animals,in
R2663	T3935	T3923	auxpass	is,increased
R2664	T3936	T3937	advmod	about,2
R2665	T3937	T3938	quantmod	2,fold
R2666	T3938	T3923	advmod	fold,increased
R2667	T3939	T3938	punct	-,fold
R2668	T3940	T3923	punct	", ",increased
R2669	T3941	T3923	prep	from,increased
R2670	T3942	T3943	nummod	11.9,%
R2671	T3943	T3941	pobj	%,from
R2672	T3944	T3923	prep	to,increased
R2673	T3945	T3946	nummod	22.2,%
R2674	T3946	T3944	pobj	%,to
R2675	T3947	T3948	punct	(,Figure
R2676	T3948	T3923	parataxis	Figure,increased
R2677	T3949	T3948	nummod	2C,Figure
R2678	T3950	T3948	punct	),Figure
R2679	T3951	T3923	punct	.,increased
R2680	T3953	T3954	det	The,proportion
R2681	T3954	T3955	nsubjpass	proportion,expanded
R2682	T3956	T3954	prep	of,proportion
R2683	T3957	T3958	det	the,region
R2684	T3958	T3956	pobj	region,of
R2685	T3959	T3958	amod	ventral,region
R2686	T3960	T3961	npadvmod	cream,colored
R2687	T3961	T3958	amod	colored,region
R2688	T3962	T3961	punct	-,colored
R2689	T3963	T3955	auxpass	is,expanded
R2690	T3964	T3955	advmod	also,expanded
R2691	T3965	T3966	det	a,amount
R2692	T3966	T3955	npadvmod	amount,expanded
R2693	T3967	T3966	amod	small,amount
R2694	T3968	T3966	punct	", ",amount
R2695	T3969	T3970	nummod	47.9,%
R2696	T3970	T3966	appos	%,amount
R2697	T3971	T3955	prep	in,expanded
R2698	T3972	T3971	pobj	mutant,in
R2699	T3973	T3955	prep	compared,expanded
R2700	T3974	T3973	prep	to,compared
R2701	T3975	T3976	nummod	37.8,%
R2702	T3976	T3974	pobj	%,to
R2703	T3977	T3976	prep	in,%
R2704	T3978	T3977	pobj	nonmutant,in
R2705	T3979	T3955	dobj	animals,expanded
R2706	T3980	T3955	punct	", ",expanded
R2707	T3981	T3955	cc	but,expanded
R2708	T3982	T3983	nsubj	expansion,is
R2709	T3983	T3955	conj	is,expanded
R2710	T3984	T3982	prep	of,expansion
R2711	T3985	T3986	det	the,region
R2712	T3986	T3984	pobj	region,of
R2713	T3987	T3986	amod	lateral,region
R2714	T3988	T3982	punct	", ",expansion
R2715	T3989	T3990	dep	which,occurs
R2716	T3990	T3982	relcl	occurs,expansion
R2717	T3991	T3990	prep	at,occurs
R2718	T3992	T3993	det	all,levels
R2719	T3993	T3991	pobj	levels,at
R2720	T3994	T3993	prep	of,levels
R2721	T3995	T3996	det	the,body
R2722	T3996	T3994	pobj	body,of
R2723	T3997	T3993	punct	", ",levels
R2724	T3998	T3993	prep	including,levels
R2725	T3999	T4000	det	the,limbs
R2726	T4000	T3998	pobj	limbs,including
R2727	T4001	T4000	cc	and,limbs
R2728	T4002	T4003	det	the,cranium
R2729	T4003	T4000	conj	cranium,limbs
R2730	T4004	T4000	punct	(,limbs
R2731	T4005	T4000	cc	but,limbs
R2732	T4006	T4005	neg	not,but
R2733	T4007	T4008	det	the,pad
R2734	T4008	T4000	conj	pad,limbs
R2735	T4009	T4008	compound	whisker,pad
R2736	T4010	T4008	punct	),pad
R2737	T4011	T3983	punct	", ",is
R2738	T4012	T4013	det	the,feature
R2739	T4013	T3983	attr	feature,is
R2740	T4014	T4013	amod	major,feature
R2741	T4015	T4013	amod	responsible,feature
R2742	T4016	T4015	prep	for,responsible
R2743	T4017	T4018	det	the,appearance
R2744	T4018	T4016	pobj	appearance,for
R2745	T4019	T4018	amod	ventralized,appearance
R2746	T4020	T4018	acl	caused,appearance
R2747	T4021	T4020	agent	by,caused
R2748	T4022	T4021	pobj	deH,by
R2749	T4023	T3983	punct	.,is
R2750	T4025	T4026	aux	To,investigate
R2751	T4026	T4027	advcl	investigate,examined
R2752	T4028	T4029	mark	whether,affects
R2753	T4029	T4026	ccomp	affects,investigate
R2754	T4030	T4029	nsubj	deH,affects
R2755	T4031	T4032	amod	other,characteristics
R2757	T4033	T4032	amod	dorsoventral,characteristics
R2758	T4034	T4032	compound	skin,characteristics
R2759	T4035	T4032	prep	besides,characteristics
R2760	T4036	T4037	compound	pigment,type
R2761	T4037	T4035	pobj	type,besides
R2762	T4038	T4037	punct	-,type
R2763	T4039	T4037	amod	switching,type
R2764	T4040	T4027	punct	", ",examined
R2765	T4041	T4027	nsubj	we,examined
R2766	T4042	T4043	poss	its,effects
R2767	T4043	T4027	dobj	effects,examined
R2768	T4044	T4043	prep	on,effects
R2769	T4045	T4046	compound	hair,length
R2770	T4046	T4044	pobj	length,on
R2771	T4047	T4046	cc	and,length
R2772	T4048	T4046	conj	pigmentation,length
R2773	T4049	T4027	prep	in,examined
R2774	T4050	T4051	det	an,background
R2775	T4051	T4049	pobj	background,in
R2776	T4052	T4053	compound	ae,ae
R2777	T4053	T4051	compound	ae,background
R2778	T4054	T4053	punct	/,ae
R2779	T4055	T4027	punct	.,examined
R2780	T4057	T4058	advmod	Overall,causes
R2782	T4059	T4058	punct	", ",causes
R2783	T4060	T4058	nsubj	deH,causes
R2784	T4062	T4063	det	a,reduction
R2785	T4063	T4058	dobj	reduction,causes
R2786	T4064	T4063	amod	small,reduction
R2787	T4065	T4064	cc	but,small
R2788	T4066	T4064	conj	consistent,small
R2789	T4067	T4063	prep	in,reduction
R2790	T4068	T4069	compound	hair,length
R2791	T4069	T4067	pobj	length,in
R2792	T4070	T4058	prep	in,causes
R2793	T4071	T4072	preconj	both,dorsum
R2794	T4072	T4070	pobj	dorsum,in
R2795	T4073	T4072	cc	and,dorsum
R2796	T4074	T4072	conj	ventrum,dorsum
R2797	T4075	T4061	punct	;,is
R2798	T4076	T4077	advmod	when,normalized
R2799	T4077	T4061	advcl	normalized,is
R2800	T4078	T4079	amod	mutant,animals
R2801	T4079	T4077	nsubjpass	animals,normalized
R2802	T4080	T4078	cc	and,mutant
R2803	T4081	T4078	conj	nonmutant,mutant
R2804	T4082	T4077	auxpass	are,normalized
R2805	T4083	T4077	prep	for,normalized
R2806	T4084	T4085	compound	body,circumference
R2807	T4085	T4083	pobj	circumference,for
R2808	T4086	T4061	punct	", ",is
R2809	T4087	T4088	amod	reduced,length
R2810	T4088	T4061	nsubj	length,is
R2811	T4089	T4088	compound	hair,length
R2812	T4090	T4091	advmod	most,apparent
R2813	T4091	T4061	acomp	apparent,is
R2814	T4092	T4061	prep	in,is
R2815	T4093	T4094	det	the,region
R2816	T4094	T4092	pobj	region,in
R2817	T4095	T4094	amod	lateral,region
R2818	T4096	T4097	punct	(,Figure
R2819	T4097	T4061	parataxis	Figure,is
R2820	T4098	T4097	nummod	2E,Figure
R2821	T4099	T4097	punct	),Figure
R2822	T4100	T4061	punct	.,is
R2823	T4102	T4103	amod	Adult,animals
R2824	T4103	T4111	nsubj	animals,exhibit
R2825	T4104	T4105	nmod	ae,ae
R2826	T4105	T4103	nmod	ae,animals
R2827	T4106	T4105	punct	/,ae
R2828	T4107	T4105	punct	;,ae
R2829	T4108	T4109	compound	deH,deH
R2830	T4109	T4105	appos	deH,ae
R2831	T4110	T4109	punct	/,deH
R2832	T4112	T4113	compound	body,size
R2833	T4113	T4115	compound	size,reduction
R2834	T4114	T4113	punct	-,size
R2835	T4115	T4111	dobj	reduction,exhibit
R2836	T4116	T4115	cc	and,reduction
R2837	T4117	T4118	amod	skeletal,abnormalities
R2838	T4118	T4115	conj	abnormalities,reduction
R2839	T4119	T4111	punct	", ",exhibit
R2840	T4120	T4111	cc	but,exhibit
R2841	T4121	T4111	conj	display,exhibit
R2842	T4122	T4123	det	no,phenotype
R2843	T4123	T4121	dobj	phenotype,display
R2844	T4124	T4125	compound	coat,color
R2845	T4125	T4123	compound	color,phenotype
R2846	T4126	T4125	punct	-,color
R2847	T4127	T4128	punct	(,shown
R2849	T4129	T4128	nsubj	data,shown
R2850	T4130	T4128	neg	not,shown
R2851	T4131	T4128	punct	),shown
R2852	T4132	T4111	punct	.,exhibit
R2853	T4134	T4135	advmod	However,are
R2854	T4136	T4135	punct	", ",are
R2855	T4137	T4138	nmod	ae,ae
R2856	T4138	T4140	nmod	ae,neonates
R2857	T4139	T4138	punct	/,ae
R2858	T4140	T4135	nsubj	neonates,are
R2859	T4141	T4138	cc	and,ae
R2860	T4142	T4143	nmod	ae,ae
R2861	T4143	T4138	conj	ae,ae
R2862	T4144	T4143	punct	/,ae
R2863	T4145	T4143	punct	;,ae
R2864	T4146	T4147	compound	deH,deH
R2865	T4147	T4143	appos	deH,ae
R2866	T4148	T4147	punct	/,deH
R2867	T4149	T4135	advmod	clearly,are
R2868	T4150	T4135	acomp	distinguishable,are
R2869	T4151	T4135	prep	in,are
R2870	T4152	T4153	det	the,days
R2872	T4154	T4153	amod	first,days
R2873	T4155	T4153	amod	few,days
R2874	T4156	T4153	prep	after,days
R2875	T4157	T4156	pobj	birth,after
R2876	T4158	T4135	punct	", ",are
R2877	T4159	T4160	advmod	when,is
R2878	T4160	T4135	advcl	is,are
R2879	T4161	T4162	det	a,gradient
R2880	T4162	T4160	nsubj	gradient,is
R2881	T4163	T4162	amod	dorsoventral,gradient
R2882	T4164	T4162	prep	of,gradient
R2883	T4165	T4166	amod	melanogenic,activity
R2884	T4166	T4164	pobj	activity,of
R2885	T4167	T4160	acomp	apparent,is
R2886	T4168	T4160	prep	under,is
R2887	T4169	T4170	det	the,skin
R2888	T4170	T4168	pobj	skin,under
R2889	T4171	T4172	punct	(,Figure
R2890	T4172	T4135	parataxis	Figure,are
R2891	T4173	T4172	nummod	2D,Figure
R2892	T4174	T4172	punct	),Figure
R2893	T4175	T4135	punct	.,are
R2894	T4177	T4178	prep	At,is
R2895	T4179	T4180	det	this,stage
R2896	T4180	T4177	pobj	stage,At
R2897	T4181	T4178	punct	", ",is
R2898	T4182	T4183	compound	melanoblast,migration
R2899	T4183	T4178	nsubj	migration,is
R2900	T4184	T4183	prep	from,migration
R2901	T4185	T4186	det	the,crest
R2902	T4186	T4184	pobj	crest,from
R2903	T4187	T4186	amod	neural,crest
R2904	T4188	T4189	advmod	mostly,complete
R2905	T4189	T4178	acomp	complete,is
R2906	T4190	T4178	punct	", ",is
R2907	T4191	T4178	cc	but,is
R2908	T4192	T4193	expl	there,is
R2909	T4193	T4178	conj	is,is
R2910	T4194	T4195	det	a,gradient
R2911	T4195	T4193	attr	gradient,is
R2912	T4196	T4195	amod	dorsoventral,gradient
R2913	T4197	T4195	prep	in,gradient
R2914	T4198	T4199	compound	melanocyte,differentiation
R2915	T4199	T4197	pobj	differentiation,in
R2916	T4200	T4199	cc	and,differentiation
R2917	T4201	T4202	compound	pigment,synthesis
R2918	T4202	T4199	conj	synthesis,differentiation
R2919	T4203	T4178	punct	.,is
R2920	T4205	T4206	det	The,skin
R2921	T4206	T4207	nsubj	skin,appears
R2922	T4208	T4206	prep	of,skin
R2923	T4209	T4210	compound	ae,ae
R2924	T4210	T4212	compound	ae,neonates
R2925	T4211	T4210	punct	/,ae
R2926	T4212	T4208	pobj	neonates,of
R2927	T4213	T4214	advmod	uniformly,dark
R2928	T4214	T4207	oprd	dark,appears
R2929	T4215	T4207	prep	over,appears
R2930	T4216	T4217	det	the,dorsum
R2931	T4217	T4215	pobj	dorsum,over
R2932	T4218	T4217	amod	entire,dorsum
R2933	T4219	T4207	punct	", ",appears
R2934	T4220	T4207	cc	but,appears
R2935	T4221	T4222	prep	in,is
R2936	T4222	T4207	conj	is,appears
R2937	T4223	T4224	nmod	ae,ae
R2938	T4224	T4226	nmod	ae,neonates
R2939	T4225	T4224	punct	/,ae
R2940	T4226	T4221	pobj	neonates,in
R2941	T4227	T4224	punct	;,ae
R2942	T4228	T4229	compound	deH,deH
R2943	T4229	T4224	appos	deH,ae
R2944	T4230	T4229	punct	/,deH
R2945	T4231	T4222	punct	", ",is
R2946	T4232	T4233	det	the,area
R2947	T4233	T4222	nsubj	area,is
R2948	T4234	T4233	prep	of,area
R2949	T4235	T4236	amod	dark,skin
R2950	T4236	T4234	pobj	skin,of
R2951	T4237	T4238	advmod	more,restricted
R2952	T4238	T4222	acomp	restricted,is
R2953	T4239	T4222	punct	", ",is
R2954	T4240	T4241	advmod	particularly,above
R2955	T4241	T4222	prep	above,is
R2956	T4242	T4243	det	the,limbs
R2957	T4243	T4241	pobj	limbs,above
R2958	T4244	T4222	punct	", ",is
R2959	T4245	T4222	cc	and,is
R2960	T4246	T4222	conj	resembles,is
R2961	T4247	T4248	det	the,pattern
R2962	T4248	T4246	dobj	pattern,resembles
R2963	T4249	T4248	prep	of,pattern
R2964	T4250	T4251	amod	dorsal,eumelanin
R2965	T4251	T4249	pobj	eumelanin,of
R2966	T4252	T4248	prep	in,pattern
R2967	T4253	T4254	nmod	at,at
R2968	T4254	T4256	nmod	at,animals
R2969	T4255	T4254	punct	/,at
R2970	T4256	T4252	pobj	animals,in
R2971	T4257	T4254	punct	;,at
R2972	T4258	T4259	compound	deH,deH
R2973	T4259	T4254	appos	deH,at
R2974	T4260	T4259	punct	/,deH
R2975	T4261	T4256	amod	adult,animals
R2976	T4262	T4222	punct	.,is
R2977	T4264	T4265	advcl	Taken,suggest
R2978	T4266	T4264	advmod	together,Taken
R2979	T4267	T4265	punct	", ",suggest
R2980	T4268	T4269	det	these,observations
R2981	T4269	T4265	nsubj	observations,suggest
R2982	T4270	T4271	mark	that,interferes
R2983	T4271	T4265	ccomp	interferes,suggest
R2984	T4272	T4271	nsubj	deH,interferes
R2985	T4273	T4271	prep	with,interferes
R2986	T4274	T4275	det	the,establishment
R2987	T4275	T4273	pobj	establishment,with
R2988	T4276	T4275	prep	of,establishment
R2989	T4277	T4278	amod	dorsoventral,patterning
R2990	T4278	T4276	pobj	patterning,of
R2991	T4279	T4271	prep	during,interferes
R2992	T4280	T4281	compound	skin,development
R2993	T4281	T4279	pobj	development,during
R2994	T4282	T4271	prep	by,interferes
R2995	T4283	T4282	pcomp	causing,by
R2996	T4284	T4285	amod	dorsal,expansion
R2997	T4285	T4283	dobj	expansion,causing
R2998	T4286	T4285	prep	of,expansion
R2999	T4287	T4288	det	a,region
R3000	T4288	T4286	pobj	region,of
R3001	T4289	T4288	amod	lateral,region
R3002	T4290	T4291	dep	that,is
R3003	T4291	T4288	relcl	is,region
R3004	T4292	T4291	advmod	normally,is
R3005	T4293	T4294	quantmod	3,5
R3006	T4294	T4296	nummod	5,mm
R3007	T4295	T4294	punct	–,5
R3008	T4296	T4291	attr	mm,is
R3009	T4297	T4296	prep	in,mm
R3010	T4298	T4297	pobj	width,in
R3011	T4299	T4265	punct	.,suggest
R3012	T4301	T4302	det	This,region
R3013	T4302	T4304	nsubj	region,serve
R3014	T4303	T4302	amod	same,region
R3015	T4305	T4304	aux	may,serve
R3016	T4306	T4304	prep	as,serve
R3017	T4307	T4308	det	a,boundary
R3018	T4308	T4306	pobj	boundary,as
R3019	T4309	T4308	prep	between,boundary
R3020	T4310	T4311	amod	dorsal,skin
R3022	T4312	T4310	cc	and,dorsal
R3023	T4313	T4310	conj	ventral,dorsal
R3024	T4314	T4304	prep	by,serve
R3025	T4315	T4314	pcomp	inhibiting,by
R3026	T4316	T4317	compound	melanocyte,differentiation
R3027	T4317	T4315	dobj	differentiation,inhibiting
R3028	T4318	T4314	punct	", ",by
R3029	T4319	T4314	conj	by,by
R3030	T4320	T4319	pcomp	promoting,by
R3031	T4321	T4322	compound	pheomelanin,synthesis
R3032	T4322	T4320	dobj	synthesis,promoting
R3033	T4323	T4319	punct	", ",by
R3034	T4324	T4319	cc	and,by
R3035	T4325	T4319	conj	by,by
R3036	T4326	T4325	pcomp	supporting,by
R3037	T4327	T4328	det	a,increase
R3038	T4328	T4326	dobj	increase,supporting
R3039	T4329	T4328	amod	progressive,increase
R3040	T4330	T4328	prep	in,increase
R3041	T4331	T4332	compound	hair,growth
R3042	T4332	T4330	pobj	growth,in
R3043	T4333	T4328	prep	from,increase
R3044	T4334	T4333	pobj	ventrum,from
R3045	T4335	T4328	prep	to,increase
R3046	T4336	T4335	pobj	dorsum,to
R3047	T4337	T4304	punct	.,serve
R3048	T4339	T4340	mark	As,described
R3049	T4340	T4341	advcl	described,expressed
R3050	T4342	T4340	advmod	below,described
R3051	T4343	T4341	punct	", ",expressed
R3052	T4344	T4345	det	the,gene
R3053	T4345	T4341	nsubjpass	gene,expressed
R3054	T4346	T4345	amod	defective,gene
R3055	T4347	T4346	prep	in,defective
R3056	T4348	T4347	pobj	deH,in
R3057	T4349	T4345	punct	", ",gene
R3058	T4350	T4345	appos	Tbx15,gene
R3059	T4351	T4341	punct	", ",expressed
R3060	T4352	T4341	auxpass	is,expressed
R3061	T4353	T4341	advmod	normally,expressed
R3062	T4354	T4341	prep	in,expressed
R3063	T4355	T4356	det	the,region
R3064	T4356	T4354	pobj	region,in
R3065	T4357	T4356	amod	dorsal,region
R3066	T4358	T4341	cc	and,expressed
R3067	T4359	T4360	advmod	therefore,is
R3068	T4360	T4341	conj	is,expressed
R3069	T4361	T4360	acomp	likely,is
R3070	T4362	T4363	aux	to,play
R3071	T4363	T4361	xcomp	play,likely
R3072	T4364	T4365	det	a,role
R3073	T4365	T4363	dobj	role,play
R3074	T4366	T4363	prep	in,play
R3075	T4367	T4366	pcomp	establishing,in
R3076	T4368	T4369	det	the,size
R3077	T4369	T4367	dobj	size,establishing
R3078	T4370	T4369	cc	and,size
R3079	T4371	T4372	amod	dorsal,extent
R3080	T4372	T4369	conj	extent,size
R3081	T4373	T4369	prep	of,size
R3082	T4374	T4375	det	the,region
R3083	T4375	T4373	pobj	region,of
R3084	T4376	T4375	amod	lateral,region
R3085	T4377	T4341	punct	.,expressed
R3088	T4613	T4614	amod	Positional,Cloning
R3089	T4615	T4614	prep	of,Cloning
R3090	T4616	T4615	pobj	deH,of
R3091	T4618	T4619	prep	As,identified
R3092	T4620	T4621	det	a,marker
R3093	T4621	T4618	pobj	marker,As
R3094	T4622	T4621	amod	visible,marker
R3095	T4623	T4619	punct	", ",identified
R3096	T4624	T4625	amod	early,studies
R3097	T4625	T4619	nsubj	studies,identified
R3098	T4626	T4625	compound	linkage,studies
R3099	T4627	T4625	prep	with,studies
R3100	T4628	T4629	det	the,allele
R3101	T4629	T4627	pobj	allele,with
R3102	T4630	T4629	amod	original,allele
R3103	T4631	T4632	amod	droopy,ear
R3104	T4632	T4629	compound	ear,allele
R3105	T4633	T4629	cc	or,allele
R3106	T4634	T4635	det	the,allele
R3107	T4635	T4629	conj	allele,allele
R3108	T4636	T4635	compound	deH,allele
R3109	T4637	T4638	det	a,position
R3110	T4638	T4619	dobj	position,identified
R3111	T4639	T4638	compound	map,position
R3112	T4640	T4638	prep	in,position
R3113	T4641	T4642	det	the,middle
R3114	T4642	T4640	pobj	middle,in
R3115	T4643	T4642	prep	of,middle
R3116	T4644	T4643	pobj	Chromosome,of
R3117	T4645	T4644	nummod	3,Chromosome
R3118	T4646	T4638	punct	", ",position
R3119	T4647	T4638	amod	distal,position
R3120	T4648	T4647	prep	to,distal
R3121	T4649	T4648	amod	matted,to
R3122	T4650	T4647	cc	and,distal
R3123	T4651	T4647	conj	proximal,distal
R3124	T4652	T4651	prep	to,proximal
R3125	T4653	T4654	compound	Varitint,waddler
R3126	T4654	T4652	pobj	waddler,to
R3127	T4655	T4654	punct	-,waddler
R3128	T4656	T4657	punct	(,Carter
R3129	T4657	T4619	meta	Carter,identified
R3130	T4658	T4657	cc	and,Carter
R3131	T4659	T4657	conj	Falconer,Carter
R3132	T4660	T4659	nummod	1951,Falconer
R3133	T4661	T4659	punct	;,Falconer
R3134	T4662	T4659	conj	Curry,Falconer
R3135	T4663	T4662	nummod	1959,Curry
R3136	T4664	T4662	punct	;,Curry
R3137	T4665	T4662	conj	Lane,Curry
R3138	T4666	T4665	cc	and,Lane
R3139	T4667	T4665	conj	Eicher,Lane
R3140	T4668	T4667	nummod	1979,Eicher
R3141	T4669	T4667	punct	;,Eicher
R3142	T4670	T4667	conj	Holmes,Eicher
R3143	T4671	T4670	nmod	et,Holmes
R3144	T4672	T4670	nmod	al.,Holmes
R3145	T4673	T4670	nummod	1981,Holmes
R3146	T4674	T4670	punct	),Holmes
R3147	T4675	T4619	punct	.,identified
R3148	T4677	T4678	nsubj	We,used
R3149	T4679	T4680	det	an,intercross
R3150	T4680	T4678	dobj	intercross,used
R3151	T4681	T4680	compound	F2,intercross
R3152	T4682	T4680	prep	with,intercross
R3153	T4683	T4684	compound	CAST,Ei
R3154	T4684	T4686	compound	Ei,mice
R3155	T4685	T4684	punct	/,Ei
R3156	T4686	T4682	pobj	mice,with
R3157	T4687	T4688	aux	to,localize
R3158	T4688	T4678	advcl	localize,used
R3159	T4689	T4688	dobj	deH,localize
R3160	T4690	T4688	prep	to,localize
R3161	T4691	T4692	det	a,interval
R3162	T4692	T4690	pobj	interval,to
R3163	T4693	T4694	nummod	0.1,cM
R3164	T4694	T4692	compound	cM,interval
R3165	T4695	T4692	prep	between,interval
R3166	T4696	T4695	pobj	D3Mit213,between
R3167	T4697	T4696	cc	and,D3Mit213
R3168	T4698	T4696	conj	16.MMHAP32FLF1,D3Mit213
R3169	T4699	T4692	punct	", ",interval
R3170	T4700	T4701	dep	which,refined
R3171	T4701	T4692	relcl	refined,interval
R3172	T4702	T4701	auxpass	was,refined
R3173	T4703	T4701	prep	by,refined
R3174	T4704	T4703	pobj	development,by
R3175	T4705	T4704	prep	of,development
R3176	T4706	T4707	det	a,contig
R3177	T4707	T4705	pobj	contig,of
R3178	T4708	T4709	amod	bacterial,chromosome
R3179	T4709	T4707	nmod	chromosome,contig
R3180	T4710	T4709	amod	artificial,chromosome
R3181	T4711	T4709	punct	(,chromosome
R3182	T4712	T4709	appos	BAC,chromosome
R3183	T4713	T4707	punct	),contig
R3184	T4714	T4707	cc	and,contig
R3185	T4715	T4716	amod	additional,markers
R3186	T4716	T4707	conj	markers,contig
R3187	T4717	T4716	prep	to,markers
R3188	T4718	T4719	det	a,region
R3189	T4719	T4717	pobj	region,to
R3190	T4720	T4721	nummod	1.4,Mb
R3191	T4721	T4719	compound	Mb,region
R3192	T4722	T4723	dep	that,contained
R3193	T4723	T4719	relcl	contained,region
R3194	T4724	T4725	nummod	eight,genes
R3195	T4725	T4723	dobj	genes,contained
R3196	T4726	T4725	punct	", ",genes
R3197	T4727	T4725	prep	including,genes
R3198	T4728	T4727	pobj	Tbx15,including
R3199	T4729	T4730	punct	(,Figure
R3200	T4730	T4688	parataxis	Figure,localize
R3201	T4731	T4730	nummod	3A,Figure
R3202	T4732	T4730	punct	),Figure
R3203	T4733	T4678	punct	.,used
R3204	T4735	T4736	nsubj	We,considered
R3205	T4737	T4736	dobj	Tbx15,considered
R3206	T4738	T4736	prep	as,considered
R3207	T4739	T4740	det	an,candidate
R3208	T4740	T4738	pobj	candidate,as
R3209	T4741	T4740	amod	excellent,candidate
R3210	T4742	T4740	prep	for,candidate
R3211	T4743	T4744	det	the,abnormalities
R3212	T4744	T4742	pobj	abnormalities,for
R3213	T4745	T4744	amod	skeletal,abnormalities
R3214	T4746	T4744	acl	caused,abnormalities
R3215	T4747	T4746	agent	by,caused
R3216	T4748	T4747	pobj	deH,by
R3217	T4749	T4736	punct	", ",considered
R3218	T4750	T4736	prep	based,considered
R3219	T4751	T4750	prep	on,based
R3220	T4752	T4751	pobj	studies,on
R3221	T4753	T4752	prep	by,studies
R3222	T4754	T4753	pobj	Agulnik,by
R3223	T4755	T4756	advmod	et,al.
R3224	T4756	T4754	advmod	al.,Agulnik
R3225	T4757	T4754	punct	(,Agulnik
R3226	T4758	T4754	npadvmod	1998,Agulnik
R3227	T4759	T4754	punct	),Agulnik
R3228	T4760	T4754	punct	", ",Agulnik
R3229	T4761	T4762	dep	who,described
R3230	T4762	T4754	relcl	described,Agulnik
R3231	T4763	T4764	poss	its,expression
R3232	T4764	T4762	dobj	expression,described
R3233	T4765	T4764	amod	embryonic,expression
R3234	T4766	T4764	prep	in,expression
R3235	T4767	T4768	det	the,region
R3236	T4768	T4766	pobj	region,in
R3237	T4769	T4768	amod	craniofacial,region
R3238	T4770	T4768	cc	and,region
R3239	T4771	T4772	amod	developing,limbs
R3240	T4772	T4768	conj	limbs,region
R3241	T4773	T4736	punct	.,considered
R3242	T4775	T4776	advcl	Using,found
R3243	T4777	T4778	compound	sequence,information
R3244	T4778	T4775	dobj	information,Using
R3245	T4779	T4778	prep	from,information
R3246	T4780	T4779	pobj	Agulnik,from
R3247	T4781	T4782	advmod	et,al.
R3248	T4782	T4780	advmod	al.,Agulnik
R3249	T4783	T4780	punct	(,Agulnik
R3250	T4784	T4780	npadvmod	1998,Agulnik
R3251	T4785	T4780	punct	),Agulnik
R3252	T4786	T4778	cc	and,information
R3253	T4787	T4788	det	the,sequence
R3255	T4789	T4790	advmod	partially,completed
R3256	T4790	T4788	amod	completed,sequence
R3257	T4791	T4792	compound	mouse,genome
R3258	T4792	T4788	compound	genome,sequence
R3259	T4793	T4776	punct	", ",found
R3260	T4794	T4776	nsubj	we,found
R3261	T4795	T4796	mark	that,amplified
R3262	T4796	T4776	ccomp	amplified,found
R3263	T4797	T4796	nsubjpass	portions,amplified
R3264	T4798	T4797	prep	of,portions
R3265	T4799	T4800	amod	several,exons
R3266	T4800	T4798	pobj	exons,of
R3267	T4801	T4800	compound	Tbx15,exons
R3268	T4802	T4796	aux	could,amplified
R3269	T4803	T4796	neg	not,amplified
R3270	T4804	T4796	auxpass	be,amplified
R3271	T4805	T4796	prep	from,amplified
R3272	T4806	T4807	nmod	deH,deH
R3273	T4807	T4809	nmod	deH,DNA
R3274	T4808	T4807	punct	/,deH
R3275	T4809	T4805	pobj	DNA,from
R3276	T4810	T4809	amod	genomic,DNA
R3277	T4811	T4776	punct	.,found
R3278	T4813	T4814	det	The,gene
R3279	T4814	T4816	nsubjpass	gene,referred
R3280	T4815	T4814	amod	same,gene
R3281	T4817	T4816	auxpass	was,referred
R3282	T4818	T4816	advmod	initially,referred
R3283	T4819	T4816	prep	to,referred
R3284	T4820	T4816	prep	as,referred
R3285	T4821	T4820	pobj	Tbx8,as
R3286	T4822	T4823	punct	(,Wattler
R3287	T4823	T4816	meta	Wattler,referred
R3288	T4824	T4823	nmod	et,Wattler
R3289	T4825	T4823	nmod	al.,Wattler
R3290	T4826	T4823	nummod	1998,Wattler
R3291	T4827	T4823	punct	),Wattler
R3292	T4828	T4816	cc	and,referred
R3293	T4829	T4830	advmod	then,renamed
R3294	T4830	T4816	conj	renamed,referred
R3295	T4831	T4830	advmod	later,renamed
R3296	T4832	T4830	oprd	Tbx14,renamed
R3297	T4833	T4830	punct	", ",renamed
R3298	T4834	T4830	cc	but,renamed
R3299	T4835	T4836	auxpass	is,referred
R3300	T4836	T4830	conj	referred,renamed
R3301	T4837	T4836	advmod	currently,referred
R3302	T4838	T4836	prep	to,referred
R3303	T4839	T4836	prep	in,referred
R3304	T4840	T4841	amod	several,genomes
R3305	T4841	T4839	pobj	genomes,in
R3306	T4842	T4841	compound	vertebrate,genomes
R3307	T4843	T4836	prep	as,referred
R3308	T4844	T4843	pobj	Tbx15,as
R3309	T4845	T4846	punct	(,Agulnik
R3310	T4846	T4836	meta	Agulnik,referred
R3311	T4847	T4846	nmod	et,Agulnik
R3312	T4848	T4846	nmod	al.,Agulnik
R3313	T4849	T4846	nummod	1998,Agulnik
R3314	T4850	T4846	punct	;,Agulnik
R3315	T4851	T4846	nmod	Begemann,Agulnik
R3316	T4852	T4846	nmod	et,Agulnik
R3317	T4853	T4846	nmod	al.,Agulnik
R3318	T4854	T4846	nummod	2002,Agulnik
R3319	T4855	T4846	punct	),Agulnik
R3320	T4856	T4816	punct	.,referred
R3321	T4858	T4859	prep	By,identified
R3322	T4860	T4858	pcomp	comparing,By
R3323	T4861	T4862	det	the,sequence
R3324	T4862	T4860	dobj	sequence,comparing
R3325	T4863	T4862	prep	of,sequence
R3326	T4864	T4865	det	a,fragment
R3327	T4865	T4863	pobj	fragment,of
R3328	T4866	T4867	nummod	1.3,kb
R3329	T4867	T4868	compound	kb,junction
R3330	T4868	T4865	compound	junction,fragment
R3331	T4869	T4865	acl	amplified,fragment
R3332	T4870	T4869	prep	from,amplified
R3333	T4871	T4872	nmod	deH,deH
R3334	T4872	T4874	nmod	deH,DNA
R3335	T4873	T4872	punct	/,deH
R3336	T4874	T4870	pobj	DNA,from
R3337	T4875	T4874	amod	genomic,DNA
R3338	T4876	T4860	prep	to,comparing
R3339	T4877	T4878	advmod	publicly,available
R3340	T4878	T4879	amod	available,sequence
R3341	T4879	T4876	pobj	sequence,to
R3342	T4880	T4881	compound	mouse,genome
R3343	T4881	T4879	compound	genome,sequence
R3344	T4882	T4859	punct	", ",identified
R3345	T4883	T4859	nsubj	we,identified
R3346	T4884	T4885	det	a,deletion
R3347	T4885	T4859	dobj	deletion,identified
R3348	T4886	T4887	nummod	216,kb
R3349	T4887	T4885	compound	kb,deletion
R3350	T4888	T4889	dep	that,extends
R3351	T4889	T4885	relcl	extends,deletion
R3352	T4890	T4889	prep	from,extends
R3353	T4891	T4892	compound	Tbx15,intron
R3354	T4892	T4890	pobj	intron,from
R3355	T4893	T4892	nummod	1,intron
R3356	T4894	T4889	prep	to,extends
R3357	T4895	T4896	nummod	148,kb
R3358	T4896	T4897	npadvmod	kb,downstream
R3359	T4897	T4894	pcomp	downstream,to
R3360	T4898	T4897	prep	of,downstream
R3361	T4899	T4900	det	the,sequence
R3362	T4900	T4898	pobj	sequence,of
R3363	T4901	T4900	compound	polyadenylation,sequence
R3364	T4902	T4900	prep	in,sequence
R3365	T4903	T4904	det	a,region
R3366	T4904	T4902	pobj	region,in
R3367	T4905	T4904	acl	annotated,region
R3368	T4906	T4905	prep	as,annotated
R3369	T4907	T4908	det	a,pseudogene
R3370	T4908	T4906	pobj	pseudogene,as
R3371	T4909	T4910	nmod	mannose,phosphate
R3372	T4910	T4914	compound	phosphate,receptor
R3373	T4911	T4910	punct	-,phosphate
R3374	T4912	T4910	nummod	6,phosphate
R3375	T4913	T4910	punct	-,phosphate
R3376	T4914	T4908	compound	receptor,pseudogene
R3377	T4915	T4908	punct	", ",pseudogene
R3378	T4916	T4917	compound	M6pr,ps
R3379	T4917	T4908	appos	ps,pseudogene
R3380	T4918	T4917	punct	-,ps
R3381	T4919	T4920	punct	(,3B
R3382	T4920	T4859	parataxis	3B,identified
R3383	T4921	T4920	nmod	Figure,3B
R3384	T4922	T4920	cc	and,3B
R3385	T4923	T4920	conj	3C,3B
R3386	T4924	T4920	punct	),3B
R3387	T4925	T4859	punct	.,identified
R3388	T4927	T4928	punct	(,Ludwig
R3389	T4929	T4928	nmod	et,Ludwig
R3390	T4930	T4928	nmod	al.,Ludwig
R3391	T4931	T4928	nummod	1992,Ludwig
R3392	T4932	T4928	punct	),Ludwig
R3393	T4933	T4928	punct	.,Ludwig
R3394	T4935	T4936	prep	By,identified
R3395	T4937	T4938	compound	Northern,blot
R3396	T4938	T4939	compound	blot,analysis
R3397	T4939	T4935	pobj	analysis,By
R3398	T4940	T4936	punct	", ",identified
R3399	T4941	T4936	nsubj	we,identified
R3400	T4942	T4943	det	a,transcript
R3401	T4943	T4936	dobj	transcript,identified
R3402	T4944	T4943	compound	fusion,transcript
R3403	T4945	T4943	acl	produced,transcript
R3404	T4946	T4945	prep	from,produced
R3405	T4947	T4948	det	the,chromosome
R3406	T4948	T4946	pobj	chromosome,from
R3407	T4949	T4948	compound	deH,chromosome
R3408	T4950	T4951	punct	(,shown
R3409	T4951	T4936	parataxis	shown,identified
R3410	T4952	T4951	nsubj	data,shown
R3411	T4953	T4951	neg	not,shown
R3412	T4954	T4951	punct	),shown
R3413	T4955	T4936	punct	.,identified
R3414	T4957	T4958	advmod	However,removes
R3415	T4959	T4958	punct	", ",removes
R3416	T4960	T4961	det	the,deletion
R3417	T4961	T4958	nsubj	deletion,removes
R3418	T4962	T4963	quantmod	534,602
R3419	T4963	T4966	nummod	602,acids
R3420	T4964	T4963	quantmod	of,602
R3421	T4965	T4963	quantmod	the,602
R3422	T4966	T4958	dobj	acids,removes
R3423	T4967	T4966	compound	amino,acids
R3424	T4968	T4966	acl	encoded,acids
R3425	T4969	T4968	agent	by,encoded
R3426	T4970	T4969	pobj	Tbx15,by
R3427	T4971	T4966	punct	(,acids
R3428	T4972	T4966	prep	including,acids
R3429	T4973	T4974	det	the,domain
R3430	T4974	T4972	pobj	domain,including
R3431	T4975	T4976	nmod	T,box
R3432	T4976	T4974	nmod	box,domain
R3433	T4977	T4976	punct	-,box
R3434	T4978	T4979	npadvmod	DNA,binding
R3435	T4979	T4974	amod	binding,domain
R3436	T4980	T4979	punct	-,binding
R3437	T4981	T4958	punct	),removes
R3438	T4982	T4958	punct	", ",removes
R3439	T4983	T4984	nmod	deH,animals
R3440	T4984	T4987	nsubj	animals,are
R3441	T4985	T4983	punct	/,deH
R3442	T4986	T4983	punct	+,deH
R3443	T4987	T4958	conj	are,removes
R3444	T4988	T4989	advmod	grossly,normal
R3445	T4989	T4987	acomp	normal,are
R3446	T4990	T4987	punct	", ",are
R3447	T4991	T4987	cc	and,are
R3448	T4992	T4993	det	the,phenotype
R3449	T4993	T4994	nsubj	phenotype,is
R3450	T4994	T4987	conj	is,are
R3451	T4995	T4993	prep	of,phenotype
R3452	T4996	T4997	compound	deH,deH
R3453	T4997	T4999	compound	deH,animals
R3454	T4998	T4997	punct	/,deH
R3455	T4999	T4995	pobj	animals,of
R3456	T5000	T4994	acomp	identical,is
R3457	T5001	T5000	prep	to,identical
R3458	T5002	T5001	pobj	that,to
R3459	T5003	T5002	acl	described,that
R3460	T5004	T5003	prep	for,described
R3461	T5005	T5006	det	the,allele
R3462	T5006	T5004	pobj	allele,for
R3463	T5007	T5006	amod	original,allele
R3464	T5008	T4994	punct	.,is
R3465	T5010	T5011	prep	In,annotated
R3466	T5012	T5010	pobj	addition,In
R3467	T5013	T5011	punct	", ",annotated
R3468	T5014	T5011	amod	other,annotated
R3469	T5015	T5014	prep	than,other
R3470	T5016	T5017	compound	M6pr,ps
R3471	T5017	T5015	pobj	ps,than
R3472	T5018	T5017	punct	-,ps
R3473	T5019	T5011	punct	", ",annotated
R3474	T5020	T5021	det	no,genes
R3475	T5021	T5011	nsubjpass	genes,annotated
R3476	T5022	T5021	amod	other,genes
R3477	T5023	T5021	cc	or,genes
R3478	T5024	T5021	conj	transcripts,genes
R3479	T5025	T5011	aux	have,annotated
R3480	T5026	T5011	auxpass	been,annotated
R3481	T5027	T5011	prep	to,annotated
R3482	T5028	T5029	det	the,deletion
R3483	T5029	T5027	pobj	deletion,to
R3484	T5030	T5031	nummod	216,kb
R3485	T5031	T5029	compound	kb,deletion
R3486	T5032	T5011	punct	.,annotated
R3487	T5034	T5035	mark	While,was
R3489	T5036	T5037	det	the,work
R3490	T5037	T5035	nsubj	work,was
R3491	T5038	T5037	amod	positional,work
R3492	T5039	T5037	compound	cloning,work
R3493	T5041	T5035	advmod	underway,was
R3494	T5042	T5040	punct	", ",generated
R3495	T5043	T5040	nsubj	one,generated
R3496	T5044	T5043	prep	of,one
R3497	T5045	T5044	pobj	us,of
R3498	T5046	T5043	punct	(,one
R3499	T5047	T5048	compound	A.,Russ
R3500	T5048	T5043	appos	Russ,one
R3501	T5049	T5043	punct	),one
R3502	T5050	T5051	det	an,mutation
R3503	T5051	T5040	dobj	mutation,generated
R3504	T5052	T5051	amod	independent,mutation
R3505	T5053	T5051	prep	of,mutation
R3506	T5054	T5053	pobj	Tbx15,of
R3507	T5055	T5040	prep	by,generated
R3508	T5056	T5057	compound	gene,targeting
R3509	T5057	T5055	pobj	targeting,by
R3510	T5058	T5057	prep	in,targeting
R3511	T5059	T5060	amod	embryonic,cells
R3512	T5060	T5058	pobj	cells,in
R3513	T5061	T5060	compound	stem,cells
R3514	T5062	T5040	punct	.,generated
R3515	T5064	T5065	det	The,allele
R3516	T5065	T5067	nsubj	allele,carries
R3517	T5066	T5065	amod	targeted,allele
R3518	T5068	T5065	punct	", ",allele
R3519	T5069	T5065	appos	Tbx15LacZ,allele
R3520	T5070	T5067	punct	", ",carries
R3521	T5071	T5072	det	an,cassette
R3522	T5072	T5067	dobj	cassette,carries
R3523	T5073	T5074	nmod	IRES,LacZ
R3524	T5074	T5072	nmod	LacZ,cassette
R3525	T5075	T5074	punct	-,LacZ
R3526	T5076	T5074	punct	-,LacZ
R3527	T5077	T5074	amod	neo,LacZ
R3528	T5078	T5072	compound	cDNA,cassette
R3529	T5079	T5080	dep	that,disrupts
R3530	T5080	T5072	relcl	disrupts,cassette
R3531	T5081	T5082	det	the,frame
R3532	T5082	T5080	dobj	frame,disrupts
R3533	T5083	T5082	amod	open,frame
R3534	T5084	T5082	compound	reading,frame
R3535	T5085	T5082	prep	at,frame
R3536	T5086	T5085	pobj	codon,at
R3537	T5087	T5086	nummod	154,codon
R3538	T5088	T5080	advmod	early,disrupts
R3539	T5089	T5080	prep	in,disrupts
R3540	T5090	T5091	det	the,domain
R3541	T5091	T5089	pobj	domain,in
R3542	T5092	T5093	compound	T,box
R3543	T5093	T5091	compound	box,domain
R3544	T5094	T5093	punct	-,box
R3545	T5095	T5096	punct	(,Figure
R3546	T5096	T5080	parataxis	Figure,disrupts
R3547	T5097	T5096	nummod	3D,Figure
R3548	T5098	T5096	punct	),Figure
R3549	T5099	T5067	punct	.,carries
R3550	T5101	T5102	nsubj	Animals,are
R3551	T5103	T5101	amod	heterozygous,Animals
R3552	T5104	T5103	prep	for,heterozygous
R3553	T5105	T5106	det	the,allele
R3554	T5106	T5104	pobj	allele,for
R3555	T5107	T5106	amod	targeted,allele
R3556	T5108	T5109	advmod	completely,normal
R3557	T5109	T5102	acomp	normal,are
R3558	T5110	T5102	prep	with,are
R3559	T5111	T5110	pobj	regard,with
R3560	T5112	T5111	prep	to,regard
R3561	T5113	T5112	pobj	size,to
R3562	T5114	T5113	punct	", ",size
R3563	T5115	T5116	amod	skeletal,morphology
R3564	T5116	T5113	conj	morphology,size
R3565	T5117	T5116	punct	", ",morphology
R3566	T5118	T5116	cc	and,morphology
R3567	T5119	T5120	compound	hair,color
R3568	T5120	T5122	compound	color,distribution
R3569	T5121	T5120	punct	-,color
R3570	T5122	T5116	conj	distribution,morphology
R3571	T5123	T5102	punct	", ",are
R3572	T5124	T5102	cc	but,are
R3573	T5125	T5126	compound	Tbx15LacZ,Tbx15LacZ
R3574	T5126	T5128	compound	Tbx15LacZ,homozygotes
R3575	T5127	T5126	punct	/,Tbx15LacZ
R3576	T5128	T5129	nsubjpass	homozygotes,noted
R3577	T5129	T5102	conj	noted,are
R3578	T5130	T5129	auxpass	were,noted
R3579	T5131	T5132	aux	to,exhibit
R3580	T5132	T5129	xcomp	exhibit,noted
R3581	T5133	T5134	amod	reduced,size
R3582	T5134	T5132	dobj	size,exhibit
R3583	T5135	T5134	compound	body,size
R3584	T5136	T5134	cc	and,size
R3585	T5137	T5138	det	an,appearance
R3586	T5138	T5134	conj	appearance,size
R3587	T5139	T5138	amod	abnormal,appearance
R3588	T5140	T5138	amod	craniofacial,appearance
R3589	T5141	T5138	amod	identical,appearance
R3590	T5142	T5141	prep	to,identical
R3591	T5143	T5142	pobj	that,to
R3592	T5144	T5143	acl	caused,that
R3593	T5145	T5144	agent	by,caused
R3594	T5146	T5145	pobj	deH,by
R3595	T5147	T5129	punct	.,noted
R3596	T5149	T5150	nsubj	We,generated
R3597	T5150	T5151	ccomp	generated,exhibited
R3598	T5152	T5153	nmod	Tbx15LacZ,deH
R3599	T5153	T5155	compound	deH,heterozygotes
R3600	T5154	T5153	punct	/,deH
R3601	T5155	T5150	dobj	heterozygotes,generated
R3602	T5156	T5155	compound	compound,heterozygotes
R3603	T5157	T5151	punct	;,exhibited
R3604	T5158	T5151	prep	on,exhibited
R3605	T5159	T5160	det	an,background
R3606	T5160	T5158	pobj	background,on
R3607	T5161	T5162	compound	Aw,at
R3608	T5162	T5160	compound	at,background
R3609	T5163	T5162	punct	/,at
R3610	T5164	T5151	punct	", ",exhibited
R3611	T5165	T5166	det	these,animals
R3612	T5166	T5151	nsubj	animals,exhibited
R3613	T5167	T5168	det	the,restriction
R3614	T5168	T5151	dobj	restriction,exhibited
R3615	T5169	T5168	amod	same,restriction
R3616	T5170	T5168	amod	abnormal,restriction
R3617	T5171	T5168	prep	of,restriction
R3618	T5172	T5173	amod	dorsal,pigmentation
R3619	T5173	T5171	pobj	pigmentation,of
R3620	T5174	T5168	prep	at,restriction
R3621	T5175	T5174	pobj	P3.5,at
R3622	T5176	T5168	cc	and,restriction
R3623	T5177	T5178	amod	expanded,area
R3624	T5178	T5168	conj	area,restriction
R3625	T5179	T5178	amod	yellow,area
R3626	T5180	T5178	compound	flank,area
R3627	T5181	T5182	mark	as,described
R3628	T5182	T5151	advcl	described,exhibited
R3629	T5183	T5182	advmod	above,described
R3630	T5184	T5182	prep	for,described
R3631	T5185	T5186	compound	deH,deH
R3632	T5186	T5188	compound	deH,animals
R3633	T5187	T5186	punct	/,deH
R3634	T5188	T5184	pobj	animals,for
R3635	T5189	T5190	punct	(,see
R3636	T5190	T5151	parataxis	see,exhibited
R3637	T5191	T5190	dobj	Figure,see
R3638	T5192	T5191	nummod	2,Figure
R3639	T5193	T5190	punct	),see
R3640	T5194	T5151	punct	.,exhibited
R3641	T5196	T5197	det	These,observations
R3642	T5197	T5198	nsubj	observations,demonstrate
R3643	T5199	T5200	mark	that,caused
R3644	T5200	T5198	ccomp	caused,demonstrate
R3645	T5201	T5202	det	the,characteristics
R3646	T5202	T5200	nsubjpass	characteristics,caused
R3647	T5203	T5202	amod	pigmentary,characteristics
R3648	T5204	T5203	cc	and,pigmentary
R3649	T5205	T5203	conj	craniofacial,pigmentary
R3650	T5206	T5202	prep	of,characteristics
R3651	T5207	T5206	pobj	deH,of
R3652	T5208	T5200	auxpass	are,caused
R3653	T5209	T5200	agent	by,caused
R3654	T5210	T5209	pobj	loss,by
R3655	T5211	T5210	prep	of,loss
R3656	T5212	T5211	pobj	function,of
R3657	T5213	T5210	prep	for,loss
R3658	T5214	T5213	pobj	Tbx15,for
R3659	T5215	T5198	punct	.,demonstrate
R3666	T5466	T5465	prep	of,Expression
R3667	T5467	T5466	pobj	Tbx15,of
R3668	T5468	T5467	cc	and,Tbx15
R3669	T5469	T5467	conj	Agouti,Tbx15
R3670	T5471	T5472	amod	Previous,studies
R3671	T5472	T5473	nsubj	studies,described
R3672	T5474	T5472	prep	by,studies
R3673	T5475	T5474	pobj	Agulnik,by
R3674	T5476	T5477	advmod	et,al.
R3675	T5477	T5475	advmod	al.,Agulnik
R3676	T5478	T5475	punct	(,Agulnik
R3677	T5479	T5475	npadvmod	1998,Agulnik
R3678	T5480	T5475	punct	),Agulnik
R3679	T5481	T5472	acl	using,studies
R3680	T5482	T5483	amod	whole,mount
R3681	T5483	T5485	nmod	mount,hybridization
R3682	T5484	T5483	punct	-,mount
R3683	T5485	T5481	dobj	hybridization,using
R3684	T5486	T5487	advmod	in,situ
R3685	T5487	T5485	amod	situ,hybridization
R3686	T5488	T5473	dobj	expression,described
R3687	T5489	T5488	prep	of,expression
R3688	T5490	T5489	pobj	Tbx15,of
R3689	T5491	T5473	prep	as,described
R3690	T5492	T5493	advmod	first,detectable
R3691	T5493	T5491	pcomp	detectable,as
R3692	T5494	T5493	prep	at,detectable
R3693	T5495	T5494	pobj	E9.5,at
R3694	T5496	T5493	prep	in,detectable
R3695	T5497	T5498	det	the,buds
R3696	T5498	T5496	pobj	buds,in
R3697	T5499	T5498	compound	limb,buds
R3698	T5500	T5493	punct	", ",detectable
R3699	T5501	T5493	advcl	progressing,detectable
R3700	T5502	T5501	prep	to,progressing
R3701	T5503	T5504	det	the,arches
R3702	T5504	T5502	pobj	arches,to
R3703	T5505	T5504	amod	branchial,arches
R3704	T5506	T5504	punct	", ",arches
R3705	T5507	T5504	conj	flanks,arches
R3706	T5508	T5507	punct	", ",flanks
R3707	T5509	T5507	cc	and,flanks
R3708	T5510	T5511	amod	craniofacial,regions
R3709	T5511	T5507	conj	regions,flanks
R3710	T5512	T5501	prep	through,progressing
R3711	T5513	T5512	pobj	E12.5,through
R3712	T5514	T5473	punct	.,described
R3713	T5516	T5517	aux	To,investigate
R3714	T5517	T5518	advcl	investigate,hybridized
R3715	T5519	T5520	det	this,pattern
R3716	T5520	T5517	dobj	pattern,investigate
R3717	T5521	T5517	prep	in,investigate
R3718	T5522	T5523	amod	more,detail
R3719	T5523	T5521	pobj	detail,in
R3720	T5524	T5518	punct	", ",hybridized
R3721	T5525	T5518	nsubj	we,hybridized
R3722	T5526	T5527	det	a,probe
R3723	T5527	T5518	dobj	probe,hybridized
R3724	T5528	T5527	compound	Tbx15,probe
R3725	T5529	T5527	compound	mRNA,probe
R3726	T5530	T5518	prep	to,hybridized
R3727	T5531	T5532	det	a,series
R3728	T5532	T5530	pobj	series,to
R3729	T5533	T5532	prep	of,series
R3730	T5534	T5535	amod	transverse,sections
R3731	T5535	T5533	pobj	sections,of
R3732	T5536	T5518	prep	at,hybridized
R3733	T5537	T5536	pobj	E12.5,at
R3734	T5538	T5518	cc	and,hybridized
R3735	T5539	T5518	conj	observed,hybridized
R3736	T5540	T5539	dobj	expression,observed
R3737	T5541	T5540	prep	in,expression
R3738	T5542	T5543	amod	multiple,tissues
R3739	T5543	T5541	pobj	tissues,in
R3740	T5544	T5543	amod	mesenchymal,tissues
R3741	T5545	T5543	prep	of,tissues
R3742	T5546	T5547	det	the,head
R3743	T5547	T5545	pobj	head,of
R3744	T5548	T5547	punct	", ",head
R3745	T5549	T5547	conj	trunk,head
R3746	T5550	T5549	punct	", ",trunk
R3747	T5551	T5549	cc	and,trunk
R3748	T5552	T5553	amod	developing,limbs
R3749	T5553	T5549	conj	limbs,trunk
R3750	T5554	T5555	punct	(,Figure
R3751	T5555	T5540	parataxis	Figure,expression
R3752	T5556	T5555	nummod	4A,Figure
R3753	T5557	T5555	punct	),Figure
R3754	T5558	T5540	punct	", ",expression
R3755	T5559	T5560	dep	much,is
R3756	T5560	T5540	relcl	is,expression
R3757	T5561	T5559	prep	of,much
R3758	T5562	T5561	pobj	which,of
R3759	T5563	T5560	acomp	consistent,is
R3760	T5564	T5563	prep	with,consistent
R3761	T5565	T5566	det	the,malformations
R3762	T5566	T5564	pobj	malformations,with
R3763	T5567	T5566	nmod	skull,malformations
R3764	T5568	T5567	punct	", ",skull
R3765	T5569	T5570	amod	cervical,vertebrae
R3766	T5570	T5567	conj	vertebrae,skull
R3767	T5571	T5570	punct	", ",vertebrae
R3768	T5572	T5570	cc	and,vertebrae
R3769	T5573	T5570	conj	limb,vertebrae
R3770	T5574	T5566	acl	reported,malformations
R3771	T5575	T5574	prep	for,reported
R3772	T5576	T5575	pobj	mice,for
R3773	T5577	T5576	acl	carrying,mice
R3774	T5578	T5579	det	the,allele
R3775	T5579	T5577	dobj	allele,carrying
R3776	T5580	T5579	amod	original,allele
R3777	T5581	T5582	amod	droopy,ear
R3778	T5582	T5579	compound	ear,allele
R3779	T5583	T5518	punct	.,hybridized
R3780	T5585	T5586	nsubj	We,were
R3781	T5587	T5588	advmod	particularly,interested
R3782	T5588	T5586	acomp	interested,were
R3783	T5589	T5588	prep	in,interested
R3784	T5590	T5589	pcomp	determining,in
R3785	T5591	T5592	det	the,nature
R3786	T5592	T5590	dobj	nature,determining
R3787	T5593	T5592	amod	exact,nature
R3788	T5594	T5592	prep	of,nature
R3789	T5595	T5596	det	the,expression
R3790	T5596	T5594	pobj	expression,of
R3791	T5597	T5596	amod	embryonic,expression
R3792	T5598	T5596	compound	flank,expression
R3793	T5599	T5592	amod	relative,nature
R3794	T5600	T5599	prep	to,relative
R3795	T5601	T5602	det	the,phenotype
R3796	T5602	T5600	pobj	phenotype,to
R3797	T5603	T5602	amod	ventralized,phenotype
R3798	T5604	T5602	prep	of,phenotype
R3799	T5605	T5606	amod	adult,mice
R3800	T5606	T5604	pobj	mice,of
R3801	T5607	T5608	nmod	deH,deH
R3802	T5608	T5606	compound	deH,mice
R3803	T5609	T5608	punct	/,deH
R3804	T5610	T5586	punct	.,were
R3805	T5612	T5613	amod	Transverse,sections
R3806	T5613	T5615	nsubj	sections,reveal
R3807	T5614	T5613	amod	abdominal,sections
R3808	T5616	T5613	prep	from,sections
R3809	T5617	T5618	amod	different,times
R3810	T5618	T5616	pobj	times,from
R3811	T5619	T5618	prep	during,times
R3812	T5620	T5619	pobj	development,during
R3813	T5621	T5622	det	a,band
R3814	T5622	T5615	dobj	band,reveal
R3815	T5623	T5622	amod	dorsolateral,band
R3816	T5624	T5622	prep	of,band
R3817	T5625	T5624	pobj	expression,of
R3818	T5626	T5622	prep	in,band
R3819	T5627	T5628	det	the,mesenchyme
R3820	T5628	T5626	pobj	mesenchyme,in
R3821	T5629	T5628	amod	superficial,mesenchyme
R3822	T5630	T5622	prep	at,band
R3823	T5631	T5630	pobj	E11.5,at
R3824	T5632	T5633	dep	that,broadens
R3825	T5633	T5622	relcl	broadens,band
R3826	T5634	T5635	preconj	both,dorsally
R3827	T5635	T5633	advmod	dorsally,broadens
R3828	T5636	T5635	cc	and,dorsally
R3829	T5637	T5635	conj	ventrally,dorsally
R3830	T5638	T5633	prep	over,broadens
R3831	T5639	T5640	det	the,days
R3832	T5640	T5638	pobj	days,over
R3833	T5641	T5640	amod	next,days
R3834	T5642	T5640	amod	several,days
R3835	T5643	T5644	punct	(,Figure
R3836	T5644	T5633	parataxis	Figure,broadens
R3837	T5645	T5644	nummod	4B,Figure
R3838	T5646	T5644	punct	),Figure
R3839	T5647	T5615	punct	.,reveal
R3840	T5649	T5650	prep	By,become
R3841	T5650	T5657	ccomp	become,expressed
R3842	T5651	T5649	pobj	E13.5,By
R3843	T5652	T5650	punct	", ",become
R3844	T5653	T5654	det	the,dermis
R3845	T5654	T5650	nsubj	dermis,become
R3846	T5655	T5654	amod	developing,dermis
R3847	T5656	T5650	aux	has,become
R3848	T5658	T5650	acomp	separated,become
R3849	T5659	T5658	prep	from,separated
R3850	T5660	T5661	det	the,mesenchyme
R3851	T5661	T5659	pobj	mesenchyme,from
R3852	T5662	T5661	amod	loose,mesenchyme
R3853	T5663	T5650	prep	by,become
R3854	T5664	T5665	det	a,layer
R3855	T5665	T5663	pobj	layer,by
R3856	T5666	T5665	amod	subcutaneous,layer
R3857	T5667	T5665	compound	muscle,layer
R3858	T5668	T5657	punct	;,expressed
R3859	T5669	T5657	nsubjpass	Tbx15,expressed
R3860	T5670	T5657	auxpass	is,expressed
R3861	T5671	T5657	prep	in,expressed
R3862	T5672	T5671	pobj	all,in
R3863	T5673	T5672	prep	of,all
R3864	T5674	T5675	det	these,layers
R3865	T5675	T5673	pobj	layers,of
R3866	T5676	T5677	advmod	as,as
R3867	T5677	T5672	cc	as,all
R3868	T5678	T5677	advmod	well,as
R3869	T5679	T5680	det	the,muscles
R3870	T5680	T5672	conj	muscles,all
R3871	T5681	T5680	amod	underlying,muscles
R3872	T5682	T5680	amod	abdominal,muscles
R3873	T5683	T5657	punct	.,expressed
R3874	T5685	T5686	prep	In,expressed
R3875	T5686	T5692	ccomp	expressed,detected
R3876	T5687	T5688	compound	P3.5,skin
R3877	T5688	T5685	pobj	skin,In
R3878	T5689	T5686	punct	", ",expressed
R3879	T5690	T5686	nsubjpass	Tbx15,expressed
R3880	T5691	T5686	auxpass	is,expressed
R3881	T5693	T5686	prep	in,expressed
R3882	T5694	T5695	preconj	both,dorsal
R3883	T5695	T5696	amod	dorsal,skin
R3884	T5696	T5693	pobj	skin,in
R3885	T5697	T5695	cc	and,dorsal
R3886	T5698	T5695	conj	ventral,dorsal
R3887	T5699	T5686	punct	", ",expressed
R3888	T5700	T5701	advmod	most,strongly
R3889	T5701	T5686	advmod	strongly,expressed
R3890	T5702	T5701	prep	in,strongly
R3891	T5703	T5704	det	the,dermis
R3892	T5704	T5702	pobj	dermis,in
R3893	T5705	T5704	amod	condensed,dermis
R3894	T5706	T5704	amod	upper,dermis
R3895	T5707	T5704	cc	and,dermis
R3896	T5708	T5709	amod	developing,sheaths
R3897	T5709	T5704	conj	sheaths,dermis
R3898	T5710	T5709	amod	dermal,sheaths
R3899	T5711	T5704	prep	of,dermis
R3900	T5712	T5713	compound	hair,follicles
R3901	T5713	T5711	pobj	follicles,of
R3902	T5714	T5692	punct	;,detected
R3903	T5715	T5716	amod	faint,expression
R3904	T5716	T5692	nsubjpass	expression,detected
R3905	T5717	T5692	aux	can,detected
R3906	T5718	T5692	advmod	also,detected
R3907	T5719	T5692	auxpass	be,detected
R3908	T5720	T5692	prep	in,detected
R3909	T5721	T5722	amod	rare,cells
R3910	T5722	T5720	pobj	cells,in
R3911	T5723	T5722	amod	dermal,cells
R3912	T5724	T5722	compound	papillae,cells
R3913	T5725	T5726	punct	(,Figure
R3914	T5726	T5692	parataxis	Figure,detected
R3915	T5727	T5726	nummod	4B,Figure
R3916	T5728	T5726	punct	),Figure
R3917	T5729	T5692	punct	.,detected
R3918	T5731	T5732	mark	Although,occur
R3919	T5732	T5742	advcl	occur,expressed
R3920	T5733	T5734	det	the,effects
R3921	T5734	T5732	nsubj	effects,occur
R3922	T5735	T5734	prep	of,effects
R3923	T5736	T5735	pobj	Agouti,of
R3924	T5737	T5734	prep	on,effects
R3925	T5738	T5739	compound	pigment,type
R3926	T5739	T5737	pobj	type,on
R3927	T5740	T5739	punct	-,type
R3928	T5741	T5739	amod	switching,type
R3929	T5743	T5732	prep	during,occur
R3930	T5744	T5745	amod	postnatal,growth
R3931	T5745	T5743	pobj	growth,during
R3932	T5746	T5745	compound	hair,growth
R3933	T5747	T5742	punct	", ",expressed
R3934	T5748	T5749	det	the,isoform
R3935	T5749	T5742	nsubjpass	isoform,expressed
R3936	T5750	T5751	amod	ventral,specific
R3937	T5751	T5749	amod	specific,isoform
R3938	T5752	T5751	punct	-,specific
R3939	T5753	T5749	prep	of,isoform
R3940	T5754	T5753	pobj	Agouti,of
R3941	T5755	T5742	auxpass	is,expressed
R3942	T5756	T5742	prep	in,expressed
R3943	T5757	T5758	amod	developing,skin
R3944	T5758	T5756	pobj	skin,in
R3945	T5759	T5742	advcl	beginning,expressed
R3946	T5760	T5759	prep	at,beginning
R3947	T5761	T5760	pobj	E11.5,at
R3948	T5762	T5742	punct	.,expressed
R3949	T5764	T5765	nsubj	We,compared
R3950	T5766	T5767	amod	adjacent,sections
R3951	T5767	T5765	dobj	sections,compared
R3952	T5768	T5767	acl	hybridized,sections
R3953	T5769	T5768	prep	with,hybridized
R3954	T5770	T5769	pobj	probes,with
R3955	T5771	T5770	prep	for,probes
R3956	T5772	T5771	pobj	Tbx15,for
R3957	T5773	T5772	cc	and,Tbx15
R3958	T5774	T5772	conj	Agouti,Tbx15
R3959	T5775	T5776	cc	and,observed
R3960	T5776	T5765	dep	observed,compared
R3961	T5777	T5778	amod	complementary,patterns
R3962	T5778	T5776	dobj	patterns,observed
R3963	T5779	T5776	prep	at,observed
R3964	T5780	T5779	pobj	E12.5,at
R3965	T5781	T5776	punct	", ",observed
R3966	T5782	T5783	mark	with,expression
R3967	T5783	T5776	advcl	expression,observed
R3968	T5784	T5783	prep	of,expression
R3969	T5785	T5784	pobj	Agouti,of
R3970	T5786	T5783	prep	in,expression
R3971	T5787	T5788	amod	ventral,skin
R3972	T5788	T5786	pobj	skin,in
R3973	T5789	T5783	cc	and,expression
R3974	T5790	T5783	conj	expression,expression
R3975	T5791	T5790	prep	of,expression
R3976	T5792	T5791	pobj	Tbx15,of
R3977	T5793	T5790	prep	in,expression
R3978	T5794	T5795	amod	dorsal,skin
R3979	T5795	T5793	pobj	skin,in
R3980	T5796	T5797	punct	(,5A
R3981	T5797	T5776	parataxis	5A,observed
R3982	T5798	T5797	nmod	Figure,5A
R3983	T5799	T5797	cc	and,5A
R3984	T5800	T5797	conj	5B,5A
R3985	T5801	T5797	punct	),5A
R3986	T5802	T5765	punct	.,compared
R3987	T5804	T5805	det	The,junction
R3988	T5805	T5806	nsubj	junction,is
R3989	T5807	T5805	prep	between,junction
R3990	T5808	T5809	compound	expression,domains
R3991	T5809	T5807	pobj	domains,between
R3992	T5810	T5806	acomp	indistinct,is
R3993	T5811	T5806	punct	", ",is
R3994	T5812	T5806	cc	and,is
R3995	T5813	T5814	prep	by,extends
R3996	T5814	T5806	conj	extends,is
R3997	T5815	T5813	pobj	E14.5,by
R3998	T5816	T5814	punct	", ",extends
R3999	T5817	T5818	compound	Tbx15,expression
R4000	T5818	T5814	nsubj	expression,extends
R4001	T5819	T5814	advmod	ventrally,extends
R4002	T5820	T5814	cc	and,extends
R4003	T5821	T5814	conj	overlaps,extends
R4004	T5822	T5821	advmod	extensively,overlaps
R4005	T5823	T5821	prep	with,overlaps
R4006	T5824	T5825	compound	Agouti,expression
R4007	T5825	T5823	pobj	expression,with
R4008	T5826	T5827	punct	(,5C
R4009	T5827	T5821	parataxis	5C,overlaps
R4010	T5828	T5827	nmod	Figure,5C
R4011	T5829	T5827	cc	and,5C
R4012	T5830	T5827	conj	5D,5C
R4013	T5831	T5827	punct	),5C
R4014	T5832	T5814	punct	.,extends
R4015	T5834	T5835	nsubj	We,examined
R4016	T5836	T5835	advmod	also,examined
R4017	T5837	T5838	det	the,effect
R4018	T5838	T5835	dobj	effect,examined
R4019	T5839	T5838	prep	of,effect
R4020	T5840	T5839	pobj	deH,of
R4021	T5841	T5838	prep	on,effect
R4022	T5842	T5841	pobj	expression,on
R4023	T5843	T5842	prep	of,expression
R4024	T5844	T5843	pobj	Agouti,of
R4025	T5845	T5835	cc	and,examined
R4026	T5846	T5835	conj	found,examined
R4027	T5847	T5848	det	no,difference
R4028	T5848	T5846	dobj	difference,found
R4029	T5849	T5848	prep	between,difference
R4030	T5850	T5849	pobj	mutant,between
R4031	T5851	T5850	cc	and,mutant
R4032	T5852	T5850	conj	nonmutant,mutant
R4033	T5853	T5846	prep	at,found
R4034	T5854	T5853	pobj	E12.5,at
R4035	T5855	T5854	cc	or,E12.5
R4036	T5856	T5854	conj	E13.5,E12.5
R4037	T5857	T5858	punct	(,shown
R4038	T5858	T5846	parataxis	shown,found
R4039	T5859	T5858	nsubj	data,shown
R4040	T5860	T5858	neg	not,shown
R4041	T5861	T5858	punct	),shown
R4042	T5862	T5835	punct	.,examined
R4043	T5864	T5865	advmod	However,appeared
R4044	T5866	T5865	punct	", ",appeared
R4045	T5867	T5865	prep	at,appeared
R4046	T5868	T5867	pobj	E14.5,at
R4047	T5869	T5865	punct	", ",appeared
R4048	T5870	T5871	det	the,gradient
R4049	T5871	T5865	nsubj	gradient,appeared
R4050	T5872	T5871	amod	normal,gradient
R4051	T5873	T5871	amod	ventral,gradient
R4052	T5874	T5873	punct	-,ventral
R4053	T5875	T5873	prep	to,ventral
R4054	T5876	T5875	punct	-,to
R4055	T5877	T5875	amod	dorsal,to
R4056	T5878	T5871	prep	of,gradient
R4057	T5879	T5880	compound	Agouti,expression
R4058	T5880	T5878	pobj	expression,of
R4059	T5881	T5882	aux	to,extend
R4060	T5882	T5865	xcomp	extend,appeared
R4061	T5883	T5884	advmod	more,dorsally
R4062	T5884	T5882	advmod	dorsally,extend
R4063	T5885	T5882	prep	in,extend
R4064	T5886	T5887	compound	deH,deH
R4065	T5887	T5889	compound	deH,embryos
R4066	T5888	T5887	punct	/,deH
R4067	T5889	T5885	pobj	embryos,in
R4068	T5890	T5891	punct	(,Figure
R4069	T5891	T5882	parataxis	Figure,extend
R4070	T5892	T5891	nummod	6A,Figure
R4071	T5893	T5891	punct	),Figure
R4072	T5894	T5865	punct	.,appeared
R4073	T5896	T5897	prep	In,extended
R4074	T5898	T5899	compound	P4.5,skin
R4075	T5899	T5896	pobj	skin,In
R4076	T5900	T5897	punct	", ",extended
R4077	T5901	T5897	nsubjpass	expression,extended
R4078	T5902	T5901	prep	of,expression
R4079	T5903	T5902	pobj	Agouti,of
R4080	T5904	T5897	auxpass	is,extended
R4081	T5905	T5897	advmod	also,extended
R4082	T5906	T5897	advmod	dorsally,extended
R4083	T5907	T5897	prep	in,extended
R4084	T5908	T5909	compound	deH,deH
R4085	T5909	T5911	compound	deH,animals
R4086	T5910	T5909	punct	/,deH
R4087	T5911	T5907	pobj	animals,in
R4088	T5912	T5897	cc	and,extended
R4089	T5913	T5897	conj	is,extended
R4090	T5914	T5915	advmod	most,apparent
R4091	T5915	T5913	acomp	apparent,is
R4092	T5916	T5913	prep	in,is
R4093	T5917	T5918	det	the,region
R4094	T5918	T5916	pobj	region,in
R4095	T5919	T5918	amod	midflank,region
R4096	T5920	T5913	prep	within,is
R4097	T5921	T5922	det	the,dermis
R4098	T5922	T5920	pobj	dermis,within
R4099	T5923	T5922	amod	upper,dermis
R4100	T5924	T5922	cc	and,dermis
R4101	T5925	T5926	amod	dermal,cells
R4102	T5926	T5922	conj	cells,dermis
R4103	T5927	T5926	compound	papillae,cells
R4104	T5928	T5929	punct	(,Figure
R4105	T5929	T5913	parataxis	Figure,is
R4106	T5930	T5929	nummod	6B,Figure
R4107	T5931	T5929	punct	),Figure
R4108	T5932	T5897	punct	.,extended
R4109	T5934	T5935	advmod	Thus,are
R4110	T5936	T5935	punct	", ",are
R4111	T5937	T5938	mark	while,explained
R4113	T5939	T5940	det	the,phenotype
R4114	T5940	T5938	nsubjpass	phenotype,explained
R4115	T5941	T5940	compound	pigmentation,phenotype
R4116	T5942	T5940	prep	of,phenotype
R4117	T5943	T5944	compound	deH,deH
R4118	T5944	T5946	compound	deH,mice
R4119	T5945	T5944	punct	/,deH
R4120	T5946	T5942	pobj	mice,of
R4121	T5947	T5938	aux	can,explained
R4122	T5948	T5938	auxpass	be,explained
R4123	T5949	T5938	punct	", ",explained
R4124	T5950	T5951	neg	not,surprisingly
R4125	T5951	T5938	advmod	surprisingly,explained
R4126	T5952	T5938	punct	", ",explained
R4127	T5953	T5938	agent	by,explained
R4128	T5954	T5955	amod	dorsal,extension
R4129	T5955	T5953	pobj	extension,by
R4130	T5956	T5955	prep	of,extension
R4131	T5957	T5958	compound	Agouti,expression
R4132	T5958	T5956	pobj	expression,of
R4133	T5959	T5955	prep	after,extension
R4134	T5960	T5959	pobj	birth,after
R4135	T5961	T5935	punct	", ",are
R4136	T5962	T5963	amod	patterned,expression
R4137	T5963	T5935	nsubj	expression,are
R4138	T5964	T5963	prep	of,expression
R4139	T5965	T5964	pobj	Tbx15,of
R4140	T5966	T5965	cc	and,Tbx15
R4141	T5967	T5965	conj	Agouti,Tbx15
R4142	T5968	T5935	acomp	apparent,are
R4143	T5969	T5970	quantmod	some,10
R4144	T5970	T5971	nummod	10,days
R4145	T5971	T5972	npadvmod	days,earlier
R4146	T5972	T5935	advmod	earlier,are
R4147	T5973	T5935	punct	", ",are
R4148	T5974	T5935	prep	between,are
R4149	T5975	T5974	pobj	E12.5,between
R4150	T5976	T5975	cc	and,E12.5
R4151	T5977	T5975	conj	E13.5,E12.5
R4152	T5978	T5935	punct	", ",are
R4153	T5979	T5935	cc	and,are
R4154	T5980	T5981	det	the,effects
R4155	T5981	T5982	nsubjpass	effects,detected
R4156	T5982	T5935	conj	detected,are
R4157	T5983	T5981	prep	of,effects
R4158	T5984	T5985	compound	Tbx15,deficiency
R4159	T5985	T5983	pobj	deficiency,of
R4160	T5986	T5981	prep	on,effects
R4161	T5987	T5986	pobj	expression,on
R4162	T5988	T5987	prep	of,expression
R4163	T5989	T5988	pobj	Agouti,of
R4164	T5990	T5982	aux	can,detected
R4165	T5991	T5982	auxpass	be,detected
R4166	T5992	T5982	prep	by,detected
R4167	T5993	T5992	pobj	E14.5,by
R4168	T5994	T5935	punct	.,are
R4169	T6166	T6165	prep	of,Relationship
R4170	T6167	T6168	amod	Embryonic,Expression
R4171	T6168	T6166	pobj	Expression,of
R4172	T6169	T6168	compound	Tbx15,Expression
R4173	T6170	T6165	prep	to,Relationship
R4174	T6171	T6172	amod	Dorsal,Domains
R4175	T6172	T6170	pobj	Domains,to
R4176	T6173	T6171	cc	and,Dorsal
R4177	T6174	T6171	conj	Ventral,Dorsal
R4178	T6175	T6172	compound	Pigmentation,Domains
R4179	T6177	T6178	det	The,observations
R4180	T6178	T6179	nsubj	observations,are
R4181	T6180	T6178	acl	described,observations
R4182	T6181	T6180	advmod	above,described
R4183	T6182	T6179	acomp	consistent,are
R4184	T6183	T6182	prep	with,consistent
R4185	T6184	T6185	det	a,model
R4186	T6185	T6183	pobj	model,with
R4187	T6186	T6187	prep	in,required
R4188	T6187	T6185	relcl	required,model
R4189	T6188	T6186	pobj	which,in
R4190	T6189	T6190	amod	transient,expression
R4191	T6190	T6187	nsubjpass	expression,required
R4192	T6191	T6190	prep	of,expression
R4193	T6192	T6191	pobj	Tbx15,of
R4194	T6193	T6190	prep	in,expression
R4195	T6194	T6195	det	the,flank
R4196	T6195	T6193	pobj	flank,in
R4197	T6196	T6195	amod	embryonic,flank
R4198	T6197	T6195	amod	dorsal,flank
R4199	T6198	T6187	auxpass	is,required
R4200	T6199	T6200	aux	to,establish
R4201	T6200	T6187	advcl	establish,required
R4202	T6201	T6202	amod	positional,identity
R4203	T6202	T6200	dobj	identity,establish
R4204	T6203	T6202	prep	of,identity
R4205	T6204	T6205	det	the,dermis
R4206	T6205	T6203	pobj	dermis,of
R4207	T6206	T6205	amod	future,dermis
R4208	T6207	T6200	punct	", ",establish
R4209	T6208	T6209	advmod	at,least
R4210	T6209	T6210	advmod	least,with
R4211	T6210	T6200	prep	with,establish
R4212	T6211	T6210	pobj	respect,with
R4213	T6212	T6211	prep	to,respect
R4214	T6213	T6214	compound	pigment,type
R4215	T6214	T6216	compound	type,synthesis
R4216	T6215	T6214	punct	-,type
R4217	T6216	T6212	pobj	synthesis,to
R4218	T6217	T6216	acl	caused,synthesis
R4219	T6218	T6217	agent	by,caused
R4220	T6219	T6220	det	the,isoform
R4221	T6220	T6218	pobj	isoform,by
R4222	T6221	T6222	amod	ventral,specific
R4223	T6222	T6220	amod	specific,isoform
R4224	T6223	T6222	punct	-,specific
R4225	T6224	T6220	compound	Agouti,isoform
R4226	T6225	T6179	punct	.,are
R4227	T6227	T6228	aux	To,investigate
R4228	T6228	T6230	advcl	investigate,carried
R4229	T6229	T6228	advmod	further,investigate
R4230	T6231	T6232	det	this,hypothesis
R4231	T6232	T6228	dobj	hypothesis,investigate
R4232	T6233	T6230	punct	", ",carried
R4233	T6234	T6230	nsubj	we,carried
R4234	T6235	T6230	prt	out,carried
R4235	T6236	T6237	compound	transplantation,experiments
R4236	T6237	T6230	dobj	experiments,carried
R4237	T6238	T6239	prep	in,isolated
R4238	T6239	T6237	relcl	isolated,experiments
R4239	T6240	T6238	pobj	which,in
R4240	T6241	T6239	nsubjpass	pieces,isolated
R4241	T6242	T6241	prep	of,pieces
R4242	T6243	T6244	amod	embryonic,skin
R4243	T6244	T6242	pobj	skin,of
R4244	T6245	T6239	auxpass	were,isolated
R4245	T6246	T6239	prep	from,isolated
R4246	T6247	T6248	amod	different,positions
R4247	T6248	T6246	pobj	positions,from
R4248	T6249	T6248	amod	dorsoventral,positions
R4249	T6250	T6230	punct	.,carried
R4250	T6252	T6253	nsubj	We,evaluated
R4251	T6254	T6255	det	the,fragments
R4252	T6255	T6253	dobj	fragments,evaluated
R4253	T6256	T6255	amod	embryonic,fragments
R4254	T6257	T6255	compound	skin,fragments
R4255	T6258	T6253	prep	for,evaluated
R4256	T6259	T6260	poss	their,potential
R4257	T6260	T6258	pobj	potential,for
R4258	T6261	T6262	aux	to,give
R4259	T6262	T6260	acl	give,potential
R4260	T6263	T6262	dobj	rise,give
R4261	T6264	T6262	prep	to,give
R4262	T6265	T6266	amod	different,colors
R4263	T6266	T6264	pobj	colors,to
R4264	T6267	T6266	compound	hair,colors
R4265	T6268	T6258	cc	and,for
R4266	T6269	T6258	conj	for,for
R4267	T6270	T6271	poss	their,expression
R4268	T6271	T6269	pobj	expression,for
R4269	T6272	T6271	prep	of,expression
R4270	T6273	T6272	pobj	Tbx15,of
R4271	T6274	T6273	cc	and,Tbx15
R4272	T6275	T6273	conj	Agouti,Tbx15
R4273	T6276	T6253	punct	.,evaluated
R4274	T6278	T6279	amod	Previous,studies
R4275	T6279	T6280	nsubj	studies,showed
R4276	T6281	T6279	prep	by,studies
R4277	T6282	T6281	pobj	Silvers,by
R4278	T6283	T6282	cc	and,Silvers
R4279	T6284	T6282	conj	colleagues,Silvers
R4280	T6285	T6286	punct	(,Poole
R4281	T6286	T6279	meta	Poole,studies
R4282	T6287	T6286	cc	and,Poole
R4283	T6288	T6286	conj	Silvers,Poole
R4284	T6289	T6288	nummod	1976,Silvers
R4285	T6290	T6288	punct	),Silvers
R4286	T6291	T6292	mark	that,gives
R4288	T6293	T6294	amod	dorsal,skin
R4289	T6294	T6292	nsubj	skin,gives
R4290	T6295	T6293	cc	and,dorsal
R4291	T6296	T6293	conj	ventral,dorsal
R4292	T6297	T6294	acl	isolated,skin
R4293	T6298	T6297	prep	from,isolated
R4294	T6299	T6300	compound	at,at
R4295	T6300	T6302	compound	at,embryos
R4296	T6301	T6300	punct	/,at
R4297	T6302	T6298	pobj	embryos,from
R4298	T6303	T6292	dobj	rise,gives
R4299	T6304	T6292	prep	to,gives
R4300	T6305	T6306	amod	black,hair
R4301	T6306	T6304	pobj	hair,to
R4302	T6307	T6305	cc	and,black
R4303	T6308	T6305	conj	yellow,black
R4304	T6309	T6292	punct	", ",gives
R4305	T6310	T6292	advmod	respectively,gives
R4306	T6311	T6292	punct	", ",gives
R4307	T6312	T6313	advmod	when,transplanted
R4308	T6313	T6292	advcl	transplanted,gives
R4309	T6314	T6313	prep	into,transplanted
R4310	T6315	T6314	pobj	testis,into
R4311	T6316	T6313	cc	and,transplanted
R4312	T6317	T6313	conj	allowed,transplanted
R4313	T6318	T6319	aux	to,develop
R4314	T6319	T6317	xcomp	develop,allowed
R4315	T6320	T6319	prep	for,develop
R4316	T6321	T6322	amod	several,weeks
R4317	T6322	T6320	pobj	weeks,for
R4318	T6323	T6280	punct	.,showed
R4319	T6325	T6326	advmod	Furthermore,demonstrated
R4320	T6327	T6326	punct	", ",demonstrated
R4321	T6328	T6329	amod	dermal,epidermal
R4322	T6329	T6331	amod	epidermal,experiments
R4323	T6330	T6329	punct	–,epidermal
R4324	T6331	T6326	nsubj	experiments,demonstrated
R4325	T6332	T6331	compound	recombination,experiments
R4326	T6333	T6331	acl	carried,experiments
R4327	T6334	T6333	prt	out,carried
R4328	T6335	T6333	prep	at,carried
R4329	T6336	T6335	pobj	E14.5,at
R4330	T6337	T6338	mark	that,carried
R4331	T6338	T6326	ccomp	carried,demonstrated
R4332	T6339	T6340	amod	positional,identity
R4333	T6340	T6338	nsubjpass	identity,carried
R4334	T6341	T6338	auxpass	is,carried
R4335	T6342	T6338	agent	by,carried
R4336	T6343	T6344	det	the,dermis
R4337	T6344	T6342	pobj	dermis,by
R4338	T6345	T6344	amod	embryonic,dermis
R4339	T6346	T6326	punct	.,demonstrated
R4340	T6348	T6349	prep	In,divided
R4341	T6350	T6351	det	a,variation
R4342	T6351	T6348	pobj	variation,In
R4343	T6352	T6351	prep	on,variation
R4344	T6353	T6354	det	this,experiment
R4345	T6354	T6352	pobj	experiment,on
R4346	T6355	T6349	punct	", ",divided
R4347	T6356	T6349	nsubj	we,divided
R4348	T6357	T6358	amod	embryonic,skin
R4349	T6358	T6349	dobj	skin,divided
R4350	T6359	T6358	prep	from,skin
R4351	T6360	T6361	compound	at,a
R4352	T6361	T6363	compound	a,embryos
R4353	T6362	T6361	punct	/,a
R4354	T6363	T6359	pobj	embryos,from
R4355	T6364	T6349	prep	into,divided
R4356	T6365	T6366	amod	dorsal,pieces
R4357	T6366	T6364	pobj	pieces,into
R4358	T6367	T6365	punct	", ",dorsal
R4359	T6368	T6365	conj	flank,dorsal
R4360	T6369	T6368	punct	", ",flank
R4361	T6370	T6368	cc	and,flank
R4362	T6371	T6368	conj	ventral,flank
R4363	T6372	T6349	cc	and,divided
R4364	T6373	T6349	conj	analyzed,divided
R4365	T6374	T6375	det	the,pieces
R4366	T6375	T6373	dobj	pieces,analyzed
R4367	T6376	T6375	amod	different,pieces
R4368	T6377	T6373	prep	for,analyzed
R4369	T6378	T6379	poss	their,ability
R4370	T6379	T6377	pobj	ability,for
R4371	T6380	T6381	aux	to,give
R4372	T6381	T6379	acl	give,ability
R4373	T6382	T6381	dobj	rise,give
R4374	T6383	T6381	prep	to,give
R4375	T6384	T6385	amod	black,hair
R4376	T6385	T6383	pobj	hair,to
R4377	T6386	T6384	cc	or,black
R4378	T6387	T6384	conj	yellow,black
R4379	T6388	T6381	prep	after,give
R4380	T6389	T6390	compound	testis,transplantation
R4381	T6390	T6388	pobj	transplantation,after
R4382	T6391	T6377	punct	", ",for
R4383	T6392	T6377	cc	and,for
R4384	T6393	T6394	punct	", ",for
R4385	T6394	T6377	conj	for,for
R4386	T6395	T6394	prep	in,for
R4387	T6396	T6395	pobj	parallel,in
R4388	T6397	T6394	punct	", ",for
R4389	T6398	T6399	compound	gene,expression
R4390	T6399	T6394	pobj	expression,for
R4391	T6400	T6373	advcl	using,analyzed
R4392	T6401	T6402	advmod	in,situ
R4393	T6402	T6403	amod	situ,hybridization
R4394	T6403	T6400	dobj	hybridization,using
R4395	T6404	T6349	punct	.,divided
R4396	T6406	T6407	prep	For,divided
R4397	T6408	T6409	det	the,purposes
R4398	T6409	T6406	pobj	purposes,For
R4399	T6410	T6409	prep	of,purposes
R4400	T6411	T6412	det	a,boundary
R4401	T6412	T6410	pobj	boundary,of
R4402	T6413	T6412	amod	reproducible,boundary
R4403	T6414	T6412	amod	morphologic,boundary
R4404	T6415	T6407	punct	", ",divided
R4405	T6416	T6407	nsubj	we,divided
R4406	T6417	T6407	dobj	flank,divided
R4407	T6418	T6417	prep	from,flank
R4408	T6419	T6418	pobj	ventral,from
R4409	T6420	T6417	appos	skin,flank
R4410	T6421	T6407	prep	based,divided
R4411	T6422	T6421	prep	on,based
R4412	T6423	T6424	det	a,change
R4413	T6424	T6422	pobj	change,on
R4414	T6425	T6424	prep	in,change
R4415	T6426	T6427	compound	skin,thickness
R4416	T6427	T6425	pobj	thickness,in
R4417	T6428	T6407	cc	and,divided
R4418	T6429	T6407	conj	divided,divided
R4419	T6430	T6429	dobj	dorsal,divided
R4420	T6431	T6430	prep	from,dorsal
R4421	T6432	T6431	pobj	flank,from
R4422	T6433	T6430	appos	skin,dorsal
R4423	T6434	T6429	prep	at,divided
R4424	T6435	T6436	det	the,level
R4425	T6436	T6434	pobj	level,at
R4426	T6437	T6436	prep	of,level
R4427	T6438	T6439	det	an,notch
R4428	T6439	T6437	pobj	notch,of
R4429	T6440	T6439	amod	ectodermal,notch
R4430	T6441	T6442	dep	that,lies
R4431	T6442	T6439	relcl	lies,notch
R4432	T6443	T6442	prep	at,lies
R4433	T6444	T6445	det	the,level
R4434	T6445	T6443	pobj	level,at
R4435	T6446	T6445	amod	same,level
R4436	T6447	T6445	prep	as,level
R4437	T6448	T6449	det	the,extent
R4438	T6449	T6447	pobj	extent,as
R4439	T6450	T6449	amod	ventral,extent
R4440	T6451	T6449	prep	of,extent
R4441	T6452	T6453	det	the,myotome
R4442	T6453	T6451	pobj	myotome,of
R4443	T6454	T6455	punct	(,Figure
R4444	T6455	T6429	parataxis	Figure,divided
R4445	T6456	T6455	nummod	7,Figure
R4446	T6457	T6455	punct	),Figure
R4447	T6458	T6459	punct	(,Huang
R4448	T6459	T6429	meta	Huang,divided
R4449	T6460	T6459	cc	and,Huang
R4450	T6461	T6459	conj	Christ,Huang
R4451	T6462	T6461	nummod	2000,Christ
R4452	T6463	T6461	punct	;,Christ
R4453	T6464	T6461	conj	Olivera,Christ
R4454	T6465	T6464	punct	-,Olivera
R4455	T6466	T6464	nmod	Martinez,Olivera
R4456	T6467	T6464	nmod	et,Olivera
R4457	T6468	T6464	nmod	al.,Olivera
R4458	T6469	T6464	nummod	2000,Olivera
R4459	T6470	T6464	punct	;,Olivera
R4460	T6471	T6464	conj	Sudo,Olivera
R4461	T6472	T6471	nmod	et,Sudo
R4462	T6473	T6471	nmod	al.,Sudo
R4463	T6474	T6471	nummod	2001,Sudo
R4464	T6475	T6471	punct	;,Sudo
R4465	T6476	T6471	conj	Burke,Sudo
R4466	T6477	T6476	cc	and,Burke
R4467	T6478	T6476	conj	Nowicki,Burke
R4468	T6479	T6478	nummod	2003,Nowicki
R4469	T6480	T6478	punct	;,Nowicki
R4470	T6481	T6478	conj	Nowicki,Nowicki
R4471	T6482	T6481	nmod	et,Nowicki
R4472	T6483	T6481	nmod	al.,Nowicki
R4473	T6484	T6481	nummod	2003,Nowicki
R4474	T6485	T6481	punct	),Nowicki
R4475	T6486	T6407	punct	.,divided
R4476	T6488	T6489	nsubj	We,found
R4477	T6490	T6491	mark	that,is
R4478	T6491	T6489	ccomp	is,found
R4479	T6492	T6491	nsubj	E12.5,is
R4480	T6493	T6494	det	the,time
R4481	T6494	T6491	attr	time,is
R4482	T6495	T6494	amod	earliest,time
R4483	T6496	T6497	prep	at,is
R4484	T6497	T6494	relcl	is,time
R4485	T6498	T6496	pobj	which,at
R4486	T6499	T6500	amod	embryonic,skin
R4487	T6500	T6497	nsubj	skin,is
R4488	T6501	T6500	amod	ventral,skin
R4489	T6502	T6497	acomp	able,is
R4490	T6503	T6504	aux	to,produce
R4491	T6504	T6502	xcomp	produce,able
R4492	T6505	T6504	dobj	hair,produce
R4493	T6506	T6507	advmod	when,transplanted
R4494	T6507	T6504	advcl	transplanted,produce
R4495	T6508	T6507	prep	to,transplanted
R4496	T6509	T6510	det	the,testis
R4497	T6510	T6508	pobj	testis,to
R4498	T6511	T6489	punct	.,found
R4499	T6513	T6514	prep	Of,gave
R4500	T6515	T6516	det	the,grafts
R4501	T6516	T6513	pobj	grafts,Of
R4502	T6517	T6518	dep	that,produced
R4503	T6518	T6516	relcl	produced,grafts
R4504	T6519	T6518	dobj	hair,produced
R4505	T6520	T6514	punct	", ",gave
R4506	T6521	T6522	amod	ventral,skin
R4507	T6522	T6514	nsubj	skin,gave
R4508	T6523	T6514	dobj	rise,gave
R4509	T6524	T6514	prep	to,gave
R4510	T6525	T6526	amod	yellow,hair
R4511	T6526	T6524	pobj	hair,to
R4512	T6527	T6528	punct	(,3
R4513	T6528	T6514	parataxis	3,gave
R4514	T6529	T6528	nsubj	n,3
R4515	T6530	T6528	punct	=,3
R4516	T6531	T6528	punct	),3
R4517	T6532	T6514	punct	", ",gave
R4518	T6533	T6514	cc	and,gave
R4519	T6534	T6535	amod	dorsal,skin
R4520	T6535	T6536	nsubj	skin,gave
R4521	T6536	T6514	conj	gave,gave
R4522	T6537	T6536	dobj	rise,gave
R4523	T6538	T6536	prep	to,gave
R4524	T6539	T6540	amod	black,hair
R4525	T6540	T6538	pobj	hair,to
R4526	T6541	T6542	punct	(,4
R4527	T6542	T6536	parataxis	4,gave
R4528	T6543	T6542	nsubj	n,4
R4529	T6544	T6542	punct	=,4
R4530	T6545	T6542	punct	),4
R4531	T6546	T6514	punct	.,gave
R4532	T6548	T6549	nsubj	Transplantation,gave
R4533	T6549	T6553	ccomp	gave,produced
R4534	T6550	T6548	prep	of,Transplantation
R4535	T6551	T6552	compound	flank,skin
R4536	T6552	T6550	pobj	skin,of
R4537	T6554	T6549	dobj	rise,gave
R4538	T6555	T6549	prep	to,gave
R4539	T6556	T6557	det	a,patch
R4540	T6557	T6555	pobj	patch,to
R4541	T6558	T6557	prep	of,patch
R4542	T6559	T6560	amod	yellow,hair
R4543	T6560	T6558	pobj	hair,of
R4544	T6561	T6557	acl	juxtaposed,patch
R4545	T6562	T6561	prep	against,juxtaposed
R4546	T6563	T6564	det	a,patch
R4547	T6564	T6562	pobj	patch,against
R4548	T6565	T6564	prep	of,patch
R4549	T6566	T6567	amod	black,hair
R4550	T6567	T6565	pobj	hair,of
R4551	T6568	T6549	prep	in,gave
R4552	T6569	T6570	nummod	85,%
R4553	T6570	T6568	pobj	%,in
R4554	T6571	T6570	prep	of,%
R4555	T6572	T6573	det	the,grafts
R4556	T6573	T6571	pobj	grafts,of
R4557	T6574	T6573	amod	successful,grafts
R4558	T6575	T6576	punct	(,13
R4559	T6576	T6549	parataxis	13,gave
R4560	T6577	T6576	nsubj	n,13
R4561	T6578	T6576	punct	=,13
R4562	T6579	T6576	punct	),13
R4563	T6580	T6553	punct	;,produced
R4564	T6581	T6582	det	the,grafts
R4565	T6582	T6553	nsubj	grafts,produced
R4566	T6583	T6582	amod	remaining,grafts
R4567	T6584	T6582	nummod	two,grafts
R4568	T6585	T6582	compound	flank,grafts
R4569	T6586	T6587	advmod	solely,black
R4570	T6587	T6588	amod	black,hair
R4571	T6588	T6553	dobj	hair,produced
R4572	T6589	T6587	cc	or,black
R4573	T6590	T6587	conj	yellow,black
R4574	T6591	T6553	punct	.,produced
R4575	T6593	T6594	prep	In,observe
R4576	T6595	T6596	det	no,case
R4577	T6596	T6593	pobj	case,In
R4578	T6597	T6594	aux	did,observe
R4579	T6598	T6594	nsubj	we,observe
R4580	T6599	T6594	dobj	intermingling,observe
R4581	T6600	T6599	prep	of,intermingling
R4582	T6601	T6602	amod	black,hairs
R4583	T6602	T6600	pobj	hairs,of
R4584	T6603	T6601	cc	and,black
R4585	T6604	T6601	conj	yellow,black
R4586	T6605	T6594	punct	.,observe
R4587	T6607	T6608	mark	As,predicted
R4588	T6608	T6609	advcl	predicted,expressed
R4589	T6610	T6608	prep	from,predicted
R4590	T6611	T6612	det	the,experiments
R4591	T6612	T6610	pobj	experiments,from
R4592	T6613	T6612	acl	using,experiments
R4593	T6614	T6615	compound	tissue,sections
R4594	T6615	T6613	dobj	sections,using
R4595	T6616	T6617	punct	(,see
R4596	T6617	T6608	parataxis	see,predicted
R4597	T6618	T6619	nmod	Figures,5
R4598	T6619	T6617	dobj	5,see
R4599	T6620	T6619	cc	and,5
R4600	T6621	T6619	conj	6,5
R4601	T6622	T6617	punct	),see
R4602	T6623	T6609	punct	", ",expressed
R4603	T6624	T6625	amod	dorsal,pieces
R4604	T6625	T6609	nsubj	pieces,expressed
R4605	T6626	T6609	dobj	Tbx15,expressed
R4606	T6627	T6626	cc	but,Tbx15
R4607	T6628	T6627	neg	not,but
R4608	T6629	T6626	conj	Agouti,Tbx15
R4609	T6630	T6609	punct	", ",expressed
R4610	T6631	T6632	mark	while,expressed
R4611	T6632	T6609	advcl	expressed,expressed
R4612	T6633	T6634	compound	flank,pieces
R4613	T6634	T6632	nsubj	pieces,expressed
R4614	T6635	T6636	det	both,genes
R4615	T6636	T6632	dobj	genes,expressed
R4616	T6637	T6638	punct	(,see
R4617	T6638	T6609	parataxis	see,expressed
R4618	T6639	T6638	dobj	Figure,see
R4619	T6640	T6639	nummod	7,Figure
R4620	T6641	T6638	punct	),see
R4621	T6642	T6609	punct	.,expressed
R4622	T6644	T6645	advmod	Thus,established
R4623	T6645	T6653	ccomp	established,maintained
R4624	T6646	T6645	punct	", ",established
R4625	T6647	T6648	amod	dorsoventral,identity
R4626	T6648	T6645	nsubjpass	identity,established
R4627	T6649	T6648	prep	for,identity
R4628	T6650	T6651	amod	adult,pigmentation
R4629	T6651	T6649	pobj	pigmentation,for
R4630	T6652	T6645	auxpass	is,established
R4631	T6654	T6645	prep	by,established
R4632	T6655	T6656	det	the,time
R4633	T6656	T6654	pobj	time,by
R4634	T6657	T6658	advmod	when,becomes
R4635	T6658	T6656	relcl	becomes,time
R4636	T6659	T6660	amod	patterned,expression
R4637	T6660	T6658	nsubj	expression,becomes
R4638	T6661	T6658	acomp	apparent,becomes
R4639	T6662	T6658	prep	for,becomes
R4640	T6663	T6662	pobj	Tbx15,for
R4641	T6664	T6663	cc	and,Tbx15
R4642	T6665	T6663	conj	Agouti,Tbx15
R4643	T6666	T6667	punct	(,E11.5
R4644	T6667	T6658	parataxis	E11.5,becomes
R4645	T6668	T6669	punct	–,E12.5
R4646	T6669	T6667	prep	E12.5,E11.5
R4647	T6670	T6667	punct	),E11.5
R4648	T6671	T6653	punct	;,maintained
R4649	T6672	T6653	advmod	furthermore,maintained
R4650	T6673	T6653	punct	", ",maintained
R4651	T6674	T6675	amod	positional,identity
R4652	T6675	T6653	nsubjpass	identity,maintained
R4653	T6676	T6653	auxpass	is,maintained
R4654	T6677	T6653	prep	throughout,maintained
R4655	T6678	T6679	amod	later,stages
R4656	T6679	T6677	pobj	stages,throughout
R4657	T6680	T6679	prep	of,stages
R4658	T6681	T6682	compound	skin,development
R4659	T6682	T6680	pobj	development,of
R4660	T6683	T6653	punct	", ",maintained
R4661	T6684	T6685	advmod	even,broadens
R4662	T6685	T6653	advcl	broadens,maintained
R4663	T6686	T6685	mark	though,broadens
R4664	T6687	T6685	nsubj	expression,broadens
R4665	T6688	T6687	prep	of,expression
R4666	T6689	T6688	pobj	Tbx15,of
R4667	T6690	T6691	aux	to,include
R4668	T6691	T6685	advcl	include,broadens
R4669	T6692	T6693	amod	ventral,skin
R4670	T6693	T6691	dobj	skin,include
R4671	T6694	T6695	advmod	as,as
R4672	T6695	T6692	cc	as,ventral
R4673	T6696	T6695	advmod	well,as
R4674	T6697	T6692	conj	dorsal,ventral
R4675	T6698	T6653	punct	.,maintained
R4676	T6884	T6883	prep	of,Relationship
R4677	T6885	T6886	det	the,Boundary
R4678	T6886	T6884	pobj	Boundary,of
R4679	T6887	T6886	amod	Dorsoventral,Boundary
R4680	T6888	T6886	compound	Pigment,Boundary
R4681	T6889	T6883	prep	to,Relationship
R4682	T6890	T6891	compound	Lineage,Compartments
R4683	T6891	T6889	pobj	Compartments,to
R4684	T6892	T6891	cc	and,Compartments
R4685	T6893	T6894	det	the,Frontier
R4686	T6894	T6891	conj	Frontier,Compartments
R4687	T6895	T6894	amod	Lateral,Frontier
R4688	T6896	T6894	amod	Somitic,Frontier
R4689	T6898	T6899	det	The,notch
R4690	T6899	T6901	nsubj	notch,is
R4691	T6900	T6899	amod	ectodermal,notch
R4692	T6902	T6903	dep	that,used
R4693	T6903	T6899	relcl	used,notch
R4694	T6904	T6903	nsubj	we,used
R4695	T6905	T6906	aux	to,mark
R4696	T6906	T6903	advcl	mark,used
R4697	T6907	T6908	det	the,boundary
R4698	T6908	T6906	dobj	boundary,mark
R4699	T6909	T6908	prep	between,boundary
R4700	T6910	T6911	amod	embryonic,dorsum
R4701	T6911	T6909	pobj	dorsum,between
R4702	T6912	T6911	cc	and,dorsum
R4703	T6913	T6914	amod	embryonic,flank
R4704	T6914	T6911	conj	flank,dorsum
R4705	T6915	T6916	det	a,feature
R4706	T6916	T6901	attr	feature,is
R4707	T6917	T6916	amod	characteristic,feature
R4708	T6918	T6901	prep	in,is
R4709	T6919	T6920	compound	vertebrate,embryos
R4710	T6920	T6918	pobj	embryos,in
R4711	T6921	T6901	punct	.,is
R4712	T6923	T6924	prep	In,serves
R4713	T6925	T6926	compound	cell,studies
R4714	T6926	T6923	pobj	studies,In
R4715	T6927	T6926	compound	lineage,studies
R4716	T6928	T6926	acl	carried,studies
R4717	T6929	T6928	prt	out,carried
R4718	T6930	T6928	prep	in,carried
R4719	T6931	T6932	det	the,system
R4720	T6932	T6930	pobj	system,in
R4721	T6933	T6932	compound	chick,system
R4722	T6934	T6924	punct	", ",serves
R4723	T6935	T6936	det	the,notch
R4724	T6936	T6924	nsubj	notch,serves
R4725	T6937	T6924	prep	as,serves
R4726	T6938	T6939	det	a,landmark
R4727	T6939	T6937	pobj	landmark,as
R4728	T6940	T6939	prep	for,landmark
R4729	T6941	T6942	det	the,boundary
R4730	T6942	T6940	pobj	boundary,for
R4731	T6943	T6942	prep	between,boundary
R4732	T6944	T6943	pobj	dermis,between
R4733	T6945	T6944	acl	derived,dermis
R4734	T6946	T6945	prep	from,derived
R4735	T6947	T6948	amod	somitic,mesoderm
R4736	T6948	T6946	pobj	mesoderm,from
R4737	T6949	T6944	cc	and,dermis
R4738	T6950	T6944	conj	dermis,dermis
R4739	T6951	T6950	acl	derived,dermis
R4740	T6952	T6951	prep	from,derived
R4741	T6953	T6954	amod	lateral,plate
R4742	T6954	T6955	compound	plate,mesoderm
R4743	T6955	T6952	pobj	mesoderm,from
R4744	T6956	T6924	cc	and,serves
R4745	T6957	T6958	aux	has,termed
R4746	T6958	T6924	conj	termed,serves
R4747	T6959	T6958	auxpass	been,termed
R4748	T6960	T6961	det	the,frontier
R4749	T6961	T6958	oprd	frontier,termed
R4750	T6962	T6961	punct	“,frontier
R4751	T6963	T6961	amod	lateral,frontier
R4752	T6964	T6961	amod	somitic,frontier
R4753	T6965	T6958	punct	”,termed
R4754	T6966	T6967	punct	(,Olivera
R4755	T6967	T6958	meta	Olivera,termed
R4756	T6968	T6967	punct	-,Olivera
R4757	T6969	T6967	nmod	Martinez,Olivera
R4758	T6970	T6967	nmod	et,Olivera
R4759	T6971	T6967	nmod	al.,Olivera
R4760	T6972	T6967	nummod	2000,Olivera
R4761	T6973	T6967	punct	;,Olivera
R4762	T6974	T6967	conj	Sudo,Olivera
R4763	T6975	T6974	nmod	et,Sudo
R4764	T6976	T6974	nmod	al.,Sudo
R4765	T6977	T6974	nummod	2001,Sudo
R4766	T6978	T6974	punct	;,Sudo
R4767	T6979	T6974	conj	Burke,Sudo
R4768	T6980	T6979	cc	and,Burke
R4769	T6981	T6979	conj	Nowicki,Burke
R4770	T6982	T6981	nummod	2003,Nowicki
R4771	T6983	T6981	punct	;,Nowicki
R4772	T6984	T6981	conj	Nowicki,Nowicki
R4773	T6985	T6984	nmod	et,Nowicki
R4774	T6986	T6984	nmod	al.,Nowicki
R4775	T6987	T6984	nummod	2003,Nowicki
R4776	T6988	T6984	punct	),Nowicki
R4777	T6989	T6924	punct	.,serves
R4778	T6991	T6992	mark	Although,carried
R4779	T6992	T7000	advcl	carried,give
R4780	T6993	T6994	npadvmod	fate,mapping
R4781	T6994	T6996	amod	mapping,studies
R4782	T6995	T6994	punct	-,mapping
R4783	T6996	T6992	nsubjpass	studies,carried
R4784	T6997	T6992	aux	have,carried
R4785	T6998	T6992	neg	not,carried
R4786	T6999	T6992	auxpass	been,carried
R4787	T7001	T6992	prt	out,carried
R4788	T7002	T6992	prep	in,carried
R4789	T7003	T7004	amod	mammalian,embryos
R4790	T7004	T7002	pobj	embryos,in
R4791	T7005	T7000	punct	", ",give
R4792	T7006	T7007	npadvmod	somite,derived
R4793	T7007	T7013	amod	derived,mesoderm
R4794	T7008	T7006	punct	-,somite
R4795	T7009	T7006	cc	and,somite
R4796	T7010	T7011	amod	lateral,plate
R4797	T7011	T7006	conj	plate,somite
R4798	T7012	T7007	punct	-,derived
R4799	T7013	T7000	nsubj	mesoderm,give
R4800	T7014	T7000	aux	could,give
R4801	T7015	T7000	dobj	rise,give
R4802	T7016	T7000	prep	to,give
R4803	T7017	T7016	pobj	precursors,to
R4804	T7018	T7000	prep	for,give
R4805	T7019	T7018	pobj	dermis,for
R4806	T7020	T7019	amod	dorsal,dermis
R4807	T7021	T7020	cc	and,dorsal
R4808	T7022	T7020	conj	ventral,dorsal
R4809	T7023	T7022	prep	to,ventral
R4810	T7024	T7025	det	the,junction
R4811	T7025	T7023	pobj	junction,to
R4812	T7026	T7025	nmod	limb,junction
R4813	T7027	T7026	punct	–,limb
R4814	T7028	T7029	compound	body,wall
R4815	T7029	T7026	appos	wall,limb
R4816	T7030	T7000	punct	", ",give
R4817	T7031	T7000	advmod	respectively,give
R4818	T7032	T7000	punct	.,give
R4819	T7034	T7035	advmod	However,conflicts
R4820	T7036	T7035	punct	", ",conflicts
R4821	T7037	T7038	det	this,notion
R4822	T7038	T7035	nsubj	notion,conflicts
R4823	T7039	T7035	prep	with,conflicts
R4824	T7040	T7041	poss	our,observation
R4825	T7041	T7039	pobj	observation,with
R4826	T7042	T7043	mark	that,lies
R4827	T7043	T7041	acl	lies,observation
R4828	T7044	T7045	det	the,boundary
R4829	T7045	T7043	nsubj	boundary,lies
R4830	T7046	T7045	amod	future,boundary
R4831	T7047	T7045	compound	pigmentation,boundary
R4832	T7048	T7043	advmod	ventral,lies
R4833	T7049	T7048	prep	to,ventral
R4834	T7050	T7051	det	the,notch
R4835	T7051	T7049	pobj	notch,to
R4836	T7052	T7051	amod	ectodermal,notch
R4837	T7053	T7054	punct	(,see
R4838	T7054	T7041	parataxis	see,observation
R4839	T7055	T7054	dobj	Figure,see
R4840	T7056	T7055	nummod	7,Figure
R4841	T7057	T7054	punct	),see
R4842	T7058	T7035	punct	.,conflicts
R4843	T7060	T7061	aux	To,examine
R4844	T7061	T7062	advcl	examine,made
R4845	T7063	T7061	advmod	directly,examine
R4846	T7064	T7065	det	the,relationship
R4847	T7065	T7061	dobj	relationship,examine
R4848	T7066	T7065	prep	between,relationship
R4849	T7067	T7068	det	the,boundary
R4850	T7068	T7066	pobj	boundary,between
R4851	T7069	T7068	compound	pigmentation,boundary
R4852	T7070	T7068	cc	and,boundary
R4853	T7071	T7068	conj	dermis,boundary
R4854	T7072	T7071	acl	derived,dermis
R4855	T7073	T7072	prep	from,derived
R4856	T7074	T7075	amod	lateral,plate
R4857	T7075	T7076	compound	plate,mesoderm
R4858	T7076	T7073	pobj	mesoderm,from
R4859	T7077	T7062	punct	", ",made
R4860	T7078	T7062	nsubj	we,made
R4861	T7079	T7062	dobj	use,made
R4862	T7080	T7062	prep	of,made
R4863	T7081	T7082	det	a,transgene
R4864	T7082	T7080	pobj	transgene,of
R4865	T7083	T7082	compound	Cre,transgene
R4866	T7084	T7082	acl	driven,transgene
R4867	T7085	T7084	agent	by,driven
R4868	T7086	T7087	det	the,promoter
R4869	T7087	T7085	pobj	promoter,by
R4870	T7088	T7087	compound	Hoxb6,promoter
R4871	T7089	T7090	dep	that,developed
R4872	T7090	T7087	relcl	developed,promoter
R4873	T7091	T7090	auxpass	was,developed
R4874	T7092	T7090	agent	by,developed
R4875	T7093	T7092	pobj	Kuehn,by
R4876	T7094	T7093	cc	and,Kuehn
R4877	T7095	T7093	conj	colleagues,Kuehn
R4878	T7096	T7097	punct	(,Lowe
R4879	T7097	T7062	meta	Lowe,made
R4880	T7098	T7097	nmod	et,Lowe
R4881	T7099	T7097	nmod	al.,Lowe
R4882	T7100	T7097	nummod	2000,Lowe
R4883	T7101	T7097	punct	),Lowe
R4884	T7102	T7062	punct	.,made
R4885	T7104	T7105	mark	As,described
R4886	T7105	T7106	advcl	described,exhibit
R4887	T7107	T7105	agent	by,described
R4888	T7108	T7107	pobj	Lowe,by
R4889	T7109	T7110	advmod	et,al.
R4890	T7110	T7108	advmod	al.,Lowe
R4891	T7111	T7108	punct	(,Lowe
R4892	T7112	T7108	npadvmod	2000,Lowe
R4893	T7113	T7108	punct	),Lowe
R4894	T7114	T7106	punct	", ",exhibit
R4895	T7115	T7116	compound	midgestation,embryos
R4896	T7116	T7106	nsubj	embryos,exhibit
R4897	T7117	T7116	acl	carrying,embryos
R4898	T7118	T7119	preconj	both,transgene
R4899	T7119	T7117	dobj	transgene,carrying
R4900	T7120	T7119	det	the,transgene
R4901	T7121	T7122	compound	Hoxb6,Cre
R4902	T7122	T7119	compound	Cre,transgene
R4903	T7123	T7122	punct	-,Cre
R4904	T7124	T7119	cc	and,transgene
R4905	T7125	T7126	det	the,gene
R4906	T7126	T7119	conj	gene,transgene
R4907	T7127	T7126	compound	R26R,gene
R4908	T7128	T7126	compound	lacZ,gene
R4909	T7129	T7126	compound	reporter,gene
R4910	T7130	T7131	punct	(,Soriano
R4911	T7131	T7126	meta	Soriano,gene
R4912	T7132	T7131	nummod	1999,Soriano
R4913	T7133	T7131	punct	),Soriano
R4914	T7134	T7135	compound	X,Gal
R4915	T7135	T7137	compound	Gal,staining
R4916	T7136	T7135	punct	-,Gal
R4917	T7137	T7106	dobj	staining,exhibit
R4918	T7138	T7106	prep	in,exhibit
R4919	T7139	T7140	amod	lateral,plate
R4920	T7140	T7141	compound	plate,mesoderm
R4921	T7141	T7138	pobj	mesoderm,in
R4922	T7142	T7141	cc	but,mesoderm
R4923	T7143	T7142	neg	not,but
R4924	T7144	T7145	npadvmod	somite,derived
R4925	T7145	T7147	amod	derived,mesoderm
R4926	T7146	T7145	punct	-,derived
R4927	T7147	T7141	conj	mesoderm,mesoderm
R4928	T7148	T7147	prep	of,mesoderm
R4929	T7149	T7150	det	the,trunk
R4930	T7150	T7148	pobj	trunk,of
R4931	T7151	T7106	punct	.,exhibit
R4932	T7153	T7154	prep	In,observed
R4933	T7155	T7156	amod	whole,mount
R4934	T7156	T7158	compound	mount,preparations
R4935	T7157	T7156	punct	-,mount
R4936	T7158	T7153	pobj	preparations,In
R4937	T7159	T7158	compound	skin,preparations
R4938	T7160	T7158	prep	from,preparations
R4939	T7161	T7162	nmod	P1.5,animals
R4940	T7162	T7160	pobj	animals,from
R4941	T7163	T7161	cc	or,P1.5
R4942	T7164	T7161	conj	P4.5,P1.5
R4943	T7165	T7162	amod	neonatal,animals
R4944	T7166	T7154	punct	", ",observed
R4945	T7167	T7154	nsubj	we,observed
R4946	T7168	T7169	det	a,band
R4947	T7169	T7154	dobj	band,observed
R4948	T7170	T7169	amod	ventral,band
R4949	T7171	T7169	prep	of,band
R4950	T7172	T7173	amod	dark,staining
R4951	T7173	T7171	pobj	staining,of
R4952	T7174	T7173	compound	X,staining
R4953	T7175	T7173	punct	-,staining
R4954	T7176	T7173	compound	Gal,staining
R4955	T7177	T7169	acl	corresponding,band
R4956	T7178	T7177	prep	to,corresponding
R4957	T7179	T7180	amod	lateral,plate
R4958	T7180	T7181	npadvmod	plate,derived
R4959	T7181	T7183	amod	derived,dermis
R4960	T7182	T7181	punct	-,derived
R4961	T7183	T7178	pobj	dermis,to
R4962	T7184	T7183	punct	", ",dermis
R4963	T7185	T7186	dep	which,represents
R4964	T7186	T7183	relcl	represents,dermis
R4965	T7187	T7188	nummod	63,%
R4966	T7188	T7186	dobj	%,represents
R4967	T7189	T7188	prep	of,%
R4968	T7190	T7191	det	the,circumference
R4969	T7191	T7189	pobj	circumference,of
R4970	T7192	T7191	amod	total,circumference
R4971	T7193	T7194	punct	(,Figure
R4972	T7194	T7154	parataxis	Figure,observed
R4973	T7195	T7194	nummod	8A,Figure
R4974	T7196	T7194	punct	),Figure
R4975	T7197	T7154	punct	.,observed
R4976	T7199	T7200	advmod	However,represents
R4977	T7200	T7215	ccomp	represents,are
R4978	T7201	T7200	punct	", ",represents
R4979	T7202	T7200	prep	in,represents
R4980	T7203	T7204	amod	parallel,preparations
R4981	T7204	T7202	pobj	preparations,in
R4982	T7205	T7204	prep	from,preparations
R4983	T7206	T7207	compound	at,at
R4984	T7207	T7209	compound	at,mice
R4985	T7208	T7207	punct	/,at
R4986	T7209	T7205	pobj	mice,from
R4987	T7210	T7200	punct	", ",represents
R4988	T7211	T7212	det	the,domain
R4989	T7212	T7200	nsubj	domain,represents
R4990	T7213	T7212	amod	ventral,domain
R4991	T7214	T7212	compound	pheomelanin,domain
R4992	T7216	T7217	nummod	47,%
R4993	T7217	T7200	dobj	%,represents
R4994	T7218	T7217	prep	of,%
R4995	T7219	T7220	det	the,circumference
R4996	T7220	T7218	pobj	circumference,of
R4997	T7221	T7220	amod	total,circumference
R4998	T7222	T7220	compound	skin,circumference
R4999	T7223	T7215	punct	;,are
R5000	T7224	T7215	advmod	therefore,are
R5001	T7225	T7215	punct	", ",are
R5002	T7226	T7227	det	the,proportions
R5003	T7227	T7215	nsubj	proportions,are
R5004	T7228	T7227	prep	of,proportions
R5005	T7229	T7230	amod	total,circumference
R5006	T7230	T7228	pobj	circumference,of
R5007	T7231	T7230	compound	skin,circumference
R5008	T7232	T7230	acl	occupied,circumference
R5009	T7233	T7232	agent	by,occupied
R5010	T7234	T7235	amod	dorsal,eumelanin
R5011	T7235	T7236	nmod	eumelanin,dermis
R5012	T7236	T7233	pobj	dermis,by
R5013	T7237	T7235	cc	and,eumelanin
R5014	T7238	T7239	npadvmod	somite,derived
R5015	T7239	T7235	conj	derived,eumelanin
R5016	T7240	T7239	punct	-,derived
R5017	T7241	T7242	nummod	53,%
R5018	T7242	T7215	attr	%,are
R5019	T7243	T7242	cc	and,%
R5020	T7244	T7245	nummod	37,%
R5021	T7245	T7242	conj	%,%
R5022	T7246	T7215	punct	", ",are
R5023	T7247	T7215	advmod	respectively,are
R5024	T7248	T7249	punct	(,Figure
R5025	T7249	T7215	parataxis	Figure,are
R5026	T7250	T7249	nummod	8B,Figure
R5027	T7251	T7249	punct	),Figure
R5028	T7252	T7215	punct	.,are
R5029	T7254	T7255	det	These,results
R5030	T7255	T7256	nsubj	results,indicate
R5031	T7257	T7258	mark	that,is
R5032	T7258	T7256	ccomp	is,indicate
R5033	T7259	T7260	det	the,boundary
R5034	T7260	T7258	nsubj	boundary,is
R5035	T7261	T7260	compound	pigmentation,boundary
R5036	T7262	T7258	advmod	clearly,is
R5037	T7263	T7258	acomp	distinct,is
R5038	T7264	T7263	prep	from,distinct
R5039	T7265	T7263	punct	", ",distinct
R5040	T7266	T7263	cc	and,distinct
R5041	T7267	T7268	advmod	more,ventral
R5042	T7268	T7263	conj	ventral,distinct
R5043	T7269	T7268	prep	to,ventral
R5044	T7270	T7268	punct	", ",ventral
R5045	T7271	T7272	det	the,boundary
R5046	T7272	T7268	conj	boundary,ventral
R5047	T7273	T7272	prep	between,boundary
R5048	T7274	T7275	amod	lateral,plate
R5049	T7275	T7276	npadvmod	plate,derived
R5050	T7276	T7281	amod	derived,dermis
R5051	T7277	T7275	punct	-,plate
R5052	T7278	T7275	cc	and,plate
R5053	T7279	T7275	conj	somite,plate
R5054	T7280	T7276	punct	-,derived
R5055	T7281	T7273	pobj	dermis,between
R5056	T7282	T7256	punct	.,indicate
R5057	T7284	T7285	mark	Because,lies
R5058	T7285	T7289	advcl	lies,wondered
R5059	T7286	T7287	det	the,boundary
R5060	T7287	T7285	nsubj	boundary,lies
R5061	T7288	T7287	compound	pigmentation,boundary
R5062	T7290	T7285	prep	in,lies
R5063	T7291	T7290	pobj	register,in
R5064	T7292	T7291	prep	with,register
R5065	T7293	T7294	det	the,junction
R5066	T7294	T7292	pobj	junction,with
R5067	T7295	T7294	nmod	limb,junction
R5068	T7296	T7295	punct	–,limb
R5069	T7297	T7298	compound	body,wall
R5070	T7298	T7295	appos	wall,limb
R5071	T7299	T7300	punct	(,see
R5072	T7300	T7285	parataxis	see,lies
R5073	T7301	T7300	dobj	Figure,see
R5074	T7302	T7301	nummod	2,Figure
R5075	T7303	T7300	punct	),see
R5076	T7304	T7289	punct	", ",wondered
R5077	T7305	T7289	nsubj	we,wondered
R5078	T7306	T7307	mark	whether,be
R5079	T7307	T7289	ccomp	be,wondered
R5080	T7308	T7307	nsubj	mechanisms,be
R5081	T7309	T7308	acl	used,mechanisms
R5082	T7310	T7309	prep	for,used
R5083	T7311	T7312	amod	dorsoventral,patterning
R5084	T7312	T7310	pobj	patterning,for
R5085	T7313	T7312	compound	limb,patterning
R5086	T7314	T7307	aux	might,be
R5087	T7315	T7307	acomp	related,be
R5088	T7316	T7315	prep	to,related
R5089	T7317	T7316	pobj	those,to
R5090	T7318	T7317	acl	used,those
R5091	T7319	T7320	aux	to,establish
R5092	T7320	T7318	advcl	establish,used
R5093	T7321	T7322	det	the,boundary
R5094	T7322	T7320	dobj	boundary,establish
R5095	T7323	T7322	compound	pigmentation,boundary
R5096	T7324	T7289	punct	.,wondered
R5097	T7326	T7327	prep	In,are
R5098	T7328	T7329	det	the,limb
R5099	T7329	T7326	pobj	limb,In
R5100	T7330	T7329	amod	developing,limb
R5101	T7331	T7327	punct	", ",are
R5102	T7332	T7327	nsubj	Engrailed1,are
R5103	T7333	T7332	punct	(,Engrailed1
R5104	T7334	T7332	appos	En1,Engrailed1
R5105	T7335	T7332	punct	),Engrailed1
R5106	T7336	T7332	punct	", ",Engrailed1
R5107	T7337	T7332	conj	Wnt7a,Engrailed1
R5108	T7338	T7337	punct	", ",Wnt7a
R5109	T7339	T7337	cc	and,Wnt7a
R5110	T7340	T7337	conj	Lmx1b,Wnt7a
R5111	T7341	T7327	attr	part,are
R5112	T7342	T7341	prep	of,part
R5113	T7343	T7344	det	a,network
R5114	T7344	T7342	pobj	network,of
R5115	T7345	T7346	poss	whose,domains
R5116	T7346	T7348	dep	domains,help
R5117	T7347	T7346	amod	restricted,domains
R5118	T7348	T7344	relcl	help,network
R5119	T7349	T7346	prep	of,domains
R5120	T7350	T7349	pobj	expression,of
R5121	T7351	T7352	aux	to,establish
R5122	T7352	T7348	xcomp	establish,help
R5123	T7353	T7354	amod	dorsoventral,identity
R5124	T7354	T7352	dobj	identity,establish
R5125	T7355	T7356	punct	(,reviewed
R5126	T7356	T7352	parataxis	reviewed,establish
R5127	T7357	T7356	prep	in,reviewed
R5128	T7358	T7357	pobj	Niswander,in
R5129	T7359	T7358	npadvmod	2003,Niswander
R5130	T7360	T7356	punct	),reviewed
R5131	T7361	T7327	punct	.,are
R5132	T7363	T7364	nsubjpass	En1,expressed
R5133	T7364	T7367	ccomp	expressed,reveal
R5134	T7365	T7364	auxpass	is,expressed
R5135	T7366	T7364	advmod	transiently,expressed
R5136	T7368	T7364	prep	in,expressed
R5137	T7369	T7370	det	the,flank
R5138	T7370	T7368	pobj	flank,in
R5139	T7371	T7370	amod	developing,flank
R5140	T7372	T7367	punct	;,reveal
R5141	T7373	T7367	prep	at,reveal
R5142	T7374	T7373	pobj	E11.5,at
R5143	T7375	T7367	punct	", ",reveal
R5144	T7376	T7377	amod	transverse,sections
R5145	T7377	T7367	nsubj	sections,reveal
R5146	T7378	T7377	amod	abdominal,sections
R5147	T7379	T7367	dobj	domains,reveal
R5148	T7380	T7367	prep	in,reveal
R5149	T7381	T7382	det	the,tube
R5150	T7382	T7380	pobj	tube,in
R5151	T7383	T7382	amod	neural,tube
R5152	T7384	T7382	punct	", ",tube
R5153	T7385	T7386	npadvmod	somite,derived
R5154	T7386	T7388	amod	derived,mesenchyme
R5155	T7387	T7386	punct	-,derived
R5156	T7388	T7382	conj	mesenchyme,tube
R5157	T7389	T7388	punct	", ",mesenchyme
R5158	T7390	T7388	cc	and,mesenchyme
R5159	T7391	T7392	det	the,wall
R5160	T7392	T7388	conj	wall,mesenchyme
R5161	T7393	T7392	amod	ventral,wall
R5162	T7394	T7392	compound	body,wall
R5163	T7395	T7396	punct	(,Figure
R5164	T7396	T7367	parataxis	Figure,reveal
R5165	T7397	T7396	nummod	8C,Figure
R5166	T7398	T7396	punct	),Figure
R5167	T7399	T7367	punct	.,reveal
R5168	T7401	T7402	det	An,section
R5169	T7402	T7404	nsubj	section,reveals
R5170	T7403	T7402	amod	adjacent,section
R5171	T7405	T7402	acl	hybridized,section
R5172	T7406	T7405	prep	with,hybridized
R5173	T7407	T7406	pobj	Tbx15,with
R5174	T7408	T7409	det	a,pattern
R5175	T7409	T7404	dobj	pattern,reveals
R5176	T7410	T7409	amod	complementary,pattern
R5177	T7411	T7409	prep	in,pattern
R5178	T7412	T7413	det	the,flank
R5179	T7413	T7411	pobj	flank,in
R5180	T7414	T7409	punct	", ",pattern
R5181	T7415	T7416	dep	which,provides
R5182	T7416	T7409	relcl	provides,pattern
R5183	T7417	T7418	amod	additional,evidence
R5184	T7418	T7416	dobj	evidence,provides
R5185	T7419	T7418	prep	for,evidence
R5186	T7420	T7421	amod	developmental,mechanisms
R5187	T7421	T7419	pobj	mechanisms,for
R5188	T7422	T7423	dep	that,establish
R5189	T7423	T7421	relcl	establish,mechanisms
R5190	T7424	T7425	det	a,boundary
R5191	T7425	T7423	dobj	boundary,establish
R5192	T7426	T7425	compound	pigmentation,boundary
R5193	T7427	T7428	advmod	entirely,within
R5194	T7428	T7425	prep	within,boundary
R5195	T7429	T7430	amod	lateral,plate
R5196	T7430	T7431	compound	plate,mesoderm
R5197	T7431	T7428	pobj	mesoderm,within
R5198	T7432	T7428	cc	and,within
R5199	T7433	T7428	conj	independent,within
R5200	T7434	T7433	prep	of,independent
R5201	T7435	T7436	compound	lineage,restrictions
R5202	T7436	T7434	pobj	restrictions,of
R5203	T7437	T7436	acl	imposed,restrictions
R5204	T7438	T7437	agent	by,imposed
R5205	T7439	T7440	det	the,frontier
R5206	T7440	T7438	pobj	frontier,by
R5207	T7441	T7440	amod	lateral,frontier
R5208	T7442	T7440	amod	somitic,frontier
R5209	T7443	T7404	punct	.,reveals
R5210	T7563	T7564	amod	Several,mutations
R5211	T7564	T7565	nsubjpass	mutations,identified
R5212	T7566	T7564	cc	and,mutations
R5213	T7567	T7564	conj	genes,mutations
R5214	T7568	T7565	aux	have,identified
R5215	T7569	T7565	auxpass	been,identified
R5216	T7570	T7571	dep	that,affect
R5217	T7571	T7565	ccomp	affect,identified
R5218	T7572	T7573	det	the,pattern
R5219	T7573	T7571	dobj	pattern,affect
R5220	T7574	T7573	prep	of,pattern
R5221	T7575	T7576	compound	hair,follicle
R5222	T7576	T7577	compound	follicle,development
R5223	T7577	T7574	pobj	development,of
R5224	T7578	T7565	punct	", ",identified
R5225	T7579	T7565	cc	but,identified
R5226	T7580	T7581	nsubj	Tbx15,is
R5227	T7581	T7565	conj	is,identified
R5228	T7582	T7583	det	the,gene
R5229	T7583	T7581	attr	gene,is
R5230	T7584	T7583	amod	only,gene
R5231	T7585	T7586	prep	of,are
R5232	T7586	T7583	relcl	are,gene
R5233	T7587	T7585	pobj	which,of
R5234	T7588	T7586	nsubj	we,are
R5235	T7589	T7586	acomp	aware,are
R5236	T7590	T7591	dep	that,affects
R5237	T7591	T7583	relcl	affects,gene
R5238	T7592	T7593	det	the,pattern
R5239	T7593	T7591	dobj	pattern,affects
R5240	T7594	T7593	prep	of,pattern
R5241	T7595	T7596	compound	hair,pigmentation
R5242	T7596	T7594	pobj	pigmentation,of
R5243	T7597	T7591	prep	in,affects
R5244	T7598	T7599	amod	different,regions
R5245	T7599	T7597	pobj	regions,in
R5246	T7600	T7599	compound	body,regions
R5247	T7601	T7581	punct	.,is
R5248	T7603	T7604	amod	Ventral,areas
R5249	T7604	T7605	nsubjpass	areas,expanded
R5250	T7606	T7607	dep	that,produce
R5251	T7607	T7604	relcl	produce,areas
R5252	T7608	T7607	advmod	normally,produce
R5253	T7609	T7610	amod	yellow,hair
R5254	T7610	T7607	dobj	hair,produce
R5255	T7611	T7607	prep	in,produce
R5256	T7612	T7613	det	the,trunk
R5257	T7613	T7611	pobj	trunk,in
R5258	T7614	T7613	punct	", ",trunk
R5259	T7615	T7613	conj	limbs,trunk
R5260	T7616	T7615	punct	", ",limbs
R5261	T7617	T7615	cc	and,limbs
R5262	T7618	T7619	amod	craniofacial,regions
R5263	T7619	T7615	conj	regions,limbs
R5264	T7620	T7605	auxpass	are,expanded
R5265	T7621	T7605	prep	in,expanded
R5266	T7622	T7623	nmod	deH,deH
R5267	T7623	T7625	compound	deH,mice
R5268	T7624	T7623	punct	/,deH
R5269	T7625	T7621	pobj	mice,in
R5270	T7626	T7605	cc	and,expanded
R5271	T7627	T7605	punct	", ",expanded
R5272	T7628	T7629	prep	in,represent
R5273	T7629	T7605	conj	represent,expanded
R5274	T7630	T7631	det	the,trunk
R5275	T7631	T7628	pobj	trunk,in
R5276	T7632	T7633	advmod	at,least
R5277	T7633	T7629	advmod	least,represent
R5278	T7634	T7629	punct	", ",represent
R5279	T7635	T7636	amod	inappropriate,expression
R5280	T7636	T7629	dobj	expression,represent
R5281	T7637	T7636	amod	dorsal,expression
R5282	T7638	T7636	prep	of,expression
R5283	T7639	T7640	det	an,isoform
R5284	T7640	T7638	pobj	isoform,of
R5285	T7641	T7640	compound	Agouti,isoform
R5286	T7642	T7640	compound	mRNA,isoform
R5287	T7643	T7644	dep	that,restricted
R5288	T7644	T7640	relcl	restricted,isoform
R5289	T7645	T7644	auxpass	is,restricted
R5290	T7646	T7644	advmod	normally,restricted
R5291	T7647	T7644	prep	to,restricted
R5292	T7648	T7649	amod	ventral,skin
R5293	T7649	T7647	pobj	skin,to
R5294	T7650	T7605	punct	.,expanded
R5295	T7652	T7653	det	The,allele
R5296	T7653	T7655	nsubjpass	allele,caused
R5297	T7654	T7653	compound	deH,allele
R5298	T7656	T7655	auxpass	is,caused
R5299	T7657	T7655	agent	by,caused
R5300	T7658	T7659	det	a,deletion
R5301	T7659	T7657	pobj	deletion,by
R5302	T7660	T7659	amod	large,deletion
R5303	T7661	T7662	dep	that,removes
R5304	T7662	T7659	relcl	removes,deletion
R5305	T7663	T7662	dobj	most,removes
R5306	T7664	T7663	prep	of,most
R5307	T7665	T7666	det	the,sequence
R5308	T7666	T7664	pobj	sequence,of
R5309	T7667	T7666	compound	Tbx15,sequence
R5310	T7668	T7666	compound	coding,sequence
R5311	T7669	T7655	punct	", ",caused
R5312	T7670	T7655	cc	but,caused
R5313	T7671	T7672	det	the,phenotype
R5314	T7672	T7674	nsubjpass	phenotype,caused
R5315	T7673	T7672	amod	pleiotropic,phenotype
R5316	T7674	T7655	conj	caused,caused
R5317	T7675	T7674	auxpass	is,caused
R5318	T7676	T7674	agent	by,caused
R5319	T7677	T7678	det	a,loss
R5320	T7678	T7676	pobj	loss,by
R5321	T7679	T7678	amod	simple,loss
R5322	T7680	T7678	prep	of,loss
R5323	T7681	T7680	pobj	function,of
R5324	T7682	T7678	prep	for,loss
R5325	T7683	T7682	pobj	Tbx15,for
R5326	T7684	T7685	advmod	rather,than
R5327	T7685	T7678	cc	than,loss
R5328	T7686	T7687	det	a,effect
R5329	T7687	T7678	conj	effect,loss
R5330	T7688	T7689	amod	dominant,negative
R5331	T7689	T7687	amod	negative,effect
R5332	T7690	T7689	punct	-,negative
R5333	T7691	T7689	cc	or,negative
R5334	T7692	T7689	conj	contiguous,negative
R5335	T7693	T7687	compound	gene,effect
R5336	T7694	T7674	punct	.,caused
R5337	T7696	T7697	prep	In,is
R5338	T7698	T7696	amod	particular,In
R5339	T7699	T7697	punct	", ",is
R5340	T7700	T7697	expl	there,is
R5341	T7701	T7702	det	no,phenotype
R5342	T7702	T7697	attr	phenotype,is
R5343	T7703	T7702	amod	heterozygous,phenotype
R5344	T7704	T7697	punct	", ",is
R5345	T7705	T7706	det	no,genes
R5346	T7706	T7708	nsubj	genes,lie
R5347	T7707	T7706	amod	other,genes
R5348	T7708	T7697	conj	lie,is
R5349	T7709	T7708	prep	within,lie
R5350	T7710	T7709	cc	or,within
R5351	T7711	T7712	advmod	close,breakpoints
R5352	T7712	T7709	conj	breakpoints,within
R5353	T7713	T7711	prep	to,close
R5354	T7714	T7712	det	the,breakpoints
R5355	T7715	T7712	compound	deletion,breakpoints
R5356	T7716	T7708	punct	", ",lie
R5357	T7717	T7708	cc	and,lie
R5358	T7718	T7719	det	the,pattern
R5359	T7719	T7721	nsubj	pattern,is
R5360	T7720	T7719	compound	expression,pattern
R5361	T7721	T7708	conj	is,lie
R5362	T7722	T7719	prep	of,pattern
R5363	T7723	T7722	pobj	Tbx15,of
R5364	T7724	T7721	acomp	consistent,is
R5365	T7725	T7724	prep	with,consistent
R5366	T7726	T7727	det	the,spectrum
R5367	T7727	T7725	pobj	spectrum,with
R5368	T7728	T7727	prep	of,spectrum
R5369	T7729	T7730	amod	phenotypic,abnormalities
R5370	T7730	T7728	pobj	abnormalities,of
R5371	T7731	T7721	prep	in,is
R5372	T7732	T7733	preconj	both,allele
R5373	T7733	T7731	pobj	allele,in
R5374	T7734	T7733	det	the,allele
R5375	T7735	T7733	amod	original,allele
R5376	T7736	T7733	compound	de,allele
R5377	T7737	T7733	cc	and,allele
R5378	T7738	T7739	det	the,allele
R5379	T7739	T7733	conj	allele,allele
R5380	T7740	T7739	compound	deH,allele
R5381	T7741	T7721	punct	.,is
R5382	T7743	T7744	advmod	Finally,has
R5383	T7745	T7744	punct	", ",has
R5384	T7746	T7747	det	a,allele
R5385	T7747	T7744	nsubj	allele,has
R5386	T7748	T7747	nmod	Tbx15,allele
R5387	T7749	T7747	amod	targeted,allele
R5388	T7750	T7751	det	the,phenotype
R5389	T7751	T7744	dobj	phenotype,has
R5390	T7752	T7751	amod	same,phenotype
R5391	T7753	T7751	prep	as,phenotype
R5392	T7754	T7753	pobj	deH,as
R5393	T7755	T7744	punct	.,has
R5394	T7757	T7758	poss	Our,results
R5395	T7758	T7759	nsubj	results,suggest
R5396	T7760	T7761	mark	that,provides
R5397	T7761	T7759	ccomp	provides,suggest
R5398	T7762	T7763	amod	patterned,expression
R5399	T7763	T7761	nsubj	expression,provides
R5400	T7764	T7763	prep	of,expression
R5401	T7765	T7764	pobj	Tbx15,of
R5402	T7766	T7767	det	an,cue
R5403	T7767	T7761	dobj	cue,provides
R5404	T7768	T7767	amod	instructional,cue
R5405	T7769	T7767	acl	required,cue
R5406	T7770	T7771	aux	to,establish
R5407	T7771	T7769	advcl	establish,required
R5408	T7772	T7773	det	the,identity
R5409	T7773	T7771	dobj	identity,establish
R5410	T7774	T7773	amod	future,identity
R5411	T7775	T7773	prep	of,identity
R5412	T7776	T7777	amod	dorsal,dermis
R5413	T7777	T7775	pobj	dermis,of
R5414	T7778	T7771	prep	with,establish
R5415	T7779	T7778	pobj	regard,with
R5416	T7780	T7779	prep	to,regard
R5417	T7781	T7782	amod	pigmentary,patterning
R5418	T7782	T7780	pobj	patterning,to
R5419	T7783	T7781	cc	and,pigmentary
R5420	T7784	T7785	compound	hair,length
R5421	T7785	T7781	conj	length,pigmentary
R5422	T7786	T7759	punct	.,suggest
R5423	T7788	T7789	det	The,edge
R5424	T7789	T7791	nsubj	edge,correspond
R5425	T7790	T7789	amod	ventral,edge
R5426	T7792	T7789	prep	of,edge
R5427	T7793	T7794	compound	Tbx15,expression
R5428	T7794	T7792	pobj	expression,of
R5429	T7795	T7789	prep	in,edge
R5430	T7796	T7797	det	the,flank
R5431	T7797	T7795	pobj	flank,in
R5432	T7798	T7797	amod	developing,flank
R5433	T7799	T7791	aux	does,correspond
R5434	T7800	T7791	neg	not,correspond
R5435	T7801	T7791	prep	to,correspond
R5436	T7802	T7803	det	a,compartment
R5437	T7803	T7801	pobj	compartment,to
R5438	T7804	T7803	amod	known,compartment
R5439	T7805	T7803	compound	lineage,compartment
R5440	T7806	T7791	punct	", ",correspond
R5441	T7807	T7791	cc	but,correspond
R5442	T7808	T7791	punct	", ",correspond
R5443	T7809	T7810	prep	like,occurs
R5444	T7810	T7791	conj	occurs,correspond
R5445	T7811	T7812	compound	limb,development
R5446	T7812	T7809	pobj	development,like
R5447	T7813	T7810	punct	", ",occurs
R5448	T7814	T7810	prep	within,occurs
R5449	T7815	T7816	amod	lateral,plate
R5450	T7816	T7817	compound	plate,mesoderm
R5451	T7817	T7814	pobj	mesoderm,within
R5452	T7818	T7791	punct	.,correspond
R5453	T7820	T7821	det	These,findings
R5454	T7821	T7822	nsubj	findings,represent
R5455	T7823	T7824	det	a,role
R5456	T7824	T7822	dobj	role,represent
R5457	T7825	T7824	amod	novel,role
R5458	T7826	T7824	prep	for,role
R5459	T7827	T7828	compound	T,box
R5460	T7828	T7830	compound	box,action
R5461	T7829	T7828	punct	-,box
R5462	T7830	T7826	pobj	action,for
R5463	T7831	T7830	compound	gene,action
R5464	T7832	T7824	prep	in,role
R5465	T7833	T7834	amod	embryonic,development
R5466	T7834	T7832	pobj	development,in
R5467	T7835	T7822	cc	and,represent
R5468	T7836	T7822	conj	provide,represent
R5469	T7837	T7836	dobj	evidence,provide
R5470	T7838	T7837	prep	for,evidence
R5471	T7839	T7840	det	a,complexity
R5472	T7840	T7838	pobj	complexity,for
R5473	T7841	T7842	advmod	previously,unappreciated
R5474	T7842	T7840	amod	unappreciated,complexity
R5475	T7843	T7840	prep	to,complexity
R5476	T7844	T7843	pobj	acquisition,to
R5477	T7845	T7844	prep	of,acquisition
R5478	T7846	T7847	amod	dorsoventral,identity
R5479	T7847	T7845	pobj	identity,of
R5480	T7848	T7847	amod	positional,identity
R5481	T7849	T7844	prep	in,acquisition
R5482	T7850	T7851	amod	mammalian,skin
R5483	T7851	T7849	pobj	skin,in
R5484	T7852	T7822	punct	.,represent
R5485	T7946	T7947	amod	Distinct,Regions
R5486	T7947	T7949	nsubj	Regions,Represent
R5487	T7948	T7947	amod	Morphologic,Regions
R5488	T7950	T7951	det	the,Sum
R5489	T7951	T7949	dobj	Sum,Represent
R5490	T7952	T7951	prep	of,Sum
R5491	T7953	T7954	amod	Different,Gradients
R5492	T7954	T7952	pobj	Gradients,of
R5493	T7956	T7957	det	The,boundary
R5494	T7957	T7959	nsubj	boundary,is
R5495	T7958	T7957	amod	visual,boundary
R5496	T7960	T7957	prep	between,boundary
R5497	T7961	T7962	amod	dorsal,skin
R5498	T7962	T7960	pobj	skin,between
R5499	T7963	T7961	cc	and,dorsal
R5500	T7964	T7961	conj	ventral,dorsal
R5501	T7965	T7957	prep	in,boundary
R5502	T7966	T7967	nmod	at,at
R5503	T7967	T7969	compound	at,mice
R5504	T7968	T7967	punct	/,at
R5505	T7969	T7965	pobj	mice,in
R5506	T7970	T7959	acomp	reminiscent,is
R5507	T7971	T7970	prep	of,reminiscent
R5508	T7972	T7973	amod	other,systems
R5509	T7973	T7971	pobj	systems,of
R5510	T7974	T7975	prep	in,enforce
R5511	T7975	T7973	relcl	enforce,systems
R5512	T7976	T7974	pobj	which,in
R5513	T7977	T7978	amod	adjacent,compartments
R5514	T7978	T7975	nsubj	compartments,enforce
R5515	T7979	T7980	det	a,choice
R5516	T7980	T7975	dobj	choice,enforce
R5517	T7981	T7980	amod	binary,choice
R5518	T7982	T7980	prep	between,choice
R5519	T7983	T7984	amod	alternative,patterns
R5520	T7984	T7982	pobj	patterns,between
R5521	T7985	T7984	prep	of,patterns
R5522	T7986	T7987	compound	gene,expression
R5523	T7987	T7985	pobj	expression,of
R5524	T7988	T7987	cc	and,expression
R5525	T7989	T7990	compound	cell,fate
R5526	T7990	T7987	conj	fate,expression
R5527	T7991	T7992	punct	(,reviewed
R5528	T7992	T7959	parataxis	reviewed,is
R5529	T7993	T7992	prep	in,reviewed
R5530	T7994	T7993	pobj	Dahmann,in
R5531	T7995	T7994	cc	and,Dahmann
R5532	T7996	T7994	conj	Basler,Dahmann
R5533	T7997	T7994	npadvmod	1999,Dahmann
R5534	T7998	T7992	punct	),reviewed
R5535	T7999	T7959	punct	.,is
R5536	T8001	T8002	advmod	However,distributed
R5537	T8003	T8002	punct	", ",distributed
R5538	T8004	T8005	compound	Agouti,mRNA
R5539	T8005	T8002	nsubjpass	mRNA,distributed
R5540	T8006	T8005	prep	in,mRNA
R5541	T8007	T8008	preconj	both,embryonic
R5542	T8008	T8009	amod	embryonic,skin
R5543	T8009	T8006	pobj	skin,in
R5544	T8010	T8008	cc	and,embryonic
R5545	T8011	T8008	conj	postnatal,embryonic
R5546	T8012	T8002	auxpass	is,distributed
R5547	T8013	T8002	prep	along,distributed
R5548	T8014	T8015	det	a,gradient
R5549	T8015	T8013	pobj	gradient,along
R5550	T8016	T8017	poss	whose,boundary
R5551	T8017	T8019	dep	boundary,is
R5552	T8018	T8017	amod	dorsal,boundary
R5553	T8019	T8015	relcl	is,gradient
R5554	T8020	T8019	acomp	indistinct,is
R5555	T8021	T8019	cc	and,is
R5556	T8022	T8019	conj	overlaps,is
R5557	T8023	T8022	prep	with,overlaps
R5558	T8024	T8025	nummod	two,gradients
R5559	T8025	T8023	pobj	gradients,with
R5560	T8026	T8025	amod	additional,gradients
R5561	T8027	T8025	acl	recognized,gradients
R5562	T8028	T8027	prep	by,recognized
R5563	T8029	T8030	poss	their,effects
R5564	T8030	T8028	pobj	effects,by
R5565	T8031	T8030	prep	on,effects
R5566	T8032	T8033	compound	hair,length
R5567	T8033	T8031	pobj	length,on
R5568	T8034	T8033	cc	and,length
R5569	T8035	T8036	amod	histochemical,staining
R5570	T8036	T8033	conj	staining,length
R5571	T8037	T8002	prep	for,distributed
R5572	T8038	T8037	pobj	melanocytes,for
R5573	T8039	T8002	punct	.,distributed
R5574	T8041	T8042	det	The,gradients
R5575	T8042	T8044	nsubj	gradients,are
R5576	T8043	T8042	nummod	three,gradients
R5577	T8045	T8044	acomp	close,are
R5578	T8046	T8045	cc	but,close
R5579	T8047	T8046	neg	not,but
R5580	T8048	T8045	conj	congruent,close
R5581	T8049	T8044	punct	", ",are
R5582	T8050	T8044	cc	and,are
R5583	T8051	T8052	nsubj	it,is
R5584	T8052	T8044	conj	is,are
R5585	T8053	T8054	poss	their,proximity
R5586	T8054	T8052	attr	proximity,is
R5587	T8055	T8056	dep	that,gives
R5588	T8056	T8052	ccomp	gives,is
R5589	T8057	T8056	dobj	rise,gives
R5590	T8058	T8056	prep	to,gives
R5591	T8059	T8060	det	the,distinction
R5592	T8060	T8058	pobj	distinction,to
R5593	T8061	T8060	amod	superficial,distinction
R5594	T8062	T8060	prep	between,distinction
R5595	T8063	T8064	amod	dorsal,skin
R5596	T8064	T8062	pobj	skin,between
R5597	T8065	T8063	cc	and,dorsal
R5598	T8066	T8063	conj	ventral,dorsal
R5599	T8067	T8064	prep	of,skin
R5600	T8068	T8069	nmod	at,at
R5601	T8069	T8071	compound	at,mice
R5602	T8070	T8069	punct	/,at
R5603	T8071	T8067	pobj	mice,of
R5604	T8072	T8052	punct	.,is
R5605	T8074	T8075	advmod	Indeed,give
R5606	T8076	T8075	punct	", ",give
R5607	T8077	T8078	amod	slight,differences
R5608	T8078	T8075	nsubj	differences,give
R5609	T8079	T8078	prep	between,differences
R5610	T8080	T8081	det	the,regions
R5611	T8081	T8079	pobj	regions,between
R5612	T8082	T8081	prep	of,regions
R5613	T8083	T8082	pobj	transition,of
R5614	T8084	T8081	prep	for,regions
R5615	T8085	T8086	compound	pigment,type
R5616	T8086	T8088	compound	type,switching
R5617	T8087	T8086	punct	-,type
R5618	T8088	T8084	pobj	switching,for
R5619	T8089	T8088	cc	and,switching
R5620	T8090	T8091	compound	pigment,content
R5621	T8091	T8088	conj	content,switching
R5622	T8092	T8075	dobj	rise,give
R5623	T8093	T8075	prep	to,give
R5624	T8094	T8095	det	a,stripe
R5625	T8095	T8093	pobj	stripe,to
R5626	T8096	T8095	amod	subtle,stripe
R5627	T8097	T8095	amod	yellow,stripe
R5628	T8098	T8095	prep	along,stripe
R5629	T8099	T8100	det	the,flank
R5630	T8100	T8098	pobj	flank,along
R5631	T8101	T8102	punct	(,see
R5632	T8102	T8075	parataxis	see,give
R5633	T8103	T8104	nmod	Figures,1
R5634	T8104	T8102	dobj	1,see
R5635	T8105	T8104	punct	", ",1
R5636	T8106	T8104	conj	2,1
R5637	T8107	T8106	punct	", ",2
R5638	T8108	T8106	cc	and,2
R5639	T8109	T8106	conj	9A,2
R5640	T8110	T8102	punct	),see
R5641	T8111	T8075	punct	.,give
R5642	T8113	T8114	nsubj	Levels,remain
R5643	T8115	T8113	prep	of,Levels
R5644	T8116	T8117	compound	Agouti,mRNA
R5645	T8117	T8115	pobj	mRNA,of
R5646	T8118	T8114	oprd	high,remain
R5647	T8119	T8114	prep	throughout,remain
R5648	T8120	T8121	det	the,ventrum
R5649	T8121	T8119	pobj	ventrum,throughout
R5650	T8122	T8121	amod	entire,ventrum
R5651	T8123	T8114	punct	", ",remain
R5652	T8124	T8114	cc	but,remain
R5653	T8125	T8126	compound	hair,content
R5654	T8126	T8128	nsubjpass	content,reduced
R5655	T8127	T8126	compound	pigment,content
R5656	T8128	T8114	conj	reduced,remain
R5657	T8129	T8128	auxpass	is,reduced
R5658	T8130	T8128	punct	", ",reduced
R5659	T8131	T8128	advcl	giving,reduced
R5660	T8132	T8131	dobj	rise,giving
R5661	T8133	T8131	prep	to,giving
R5662	T8134	T8135	det	a,region
R5663	T8135	T8133	pobj	region,to
R5664	T8136	T8137	npadvmod	cream,colored
R5665	T8137	T8135	amod	colored,region
R5666	T8138	T8137	punct	-,colored
R5667	T8139	T8135	prep	in,region
R5668	T8140	T8141	det	the,ventrum
R5669	T8141	T8139	pobj	ventrum,in
R5670	T8142	T8143	dep	that,appear
R5671	T8143	T8135	relcl	appear,region
R5672	T8144	T8143	punct	", ",appear
R5673	T8145	T8143	prep	depending,appear
R5674	T8146	T8145	prep	on,depending
R5675	T8147	T8146	pobj	age,on
R5676	T8148	T8147	cc	and,age
R5677	T8149	T8150	amod	genetic,backgrounds
R5678	T8150	T8147	conj	backgrounds,age
R5679	T8151	T8143	punct	", ",appear
R5680	T8152	T8143	aux	may,appear
R5681	T8153	T8154	advmod	more,distinct
R5682	T8154	T8143	oprd	distinct,appear
R5683	T8155	T8153	cc	or,more
R5684	T8156	T8153	conj	less,more
R5685	T8157	T8154	prep	from,distinct
R5686	T8158	T8159	det	the,stripe
R5687	T8159	T8157	pobj	stripe,from
R5688	T8160	T8159	amod	yellow,stripe
R5689	T8161	T8159	compound	flank,stripe
R5690	T8162	T8128	punct	.,reduced
R5691	T8164	T8165	nsubj	Loss,affects
R5692	T8165	T8168	ccomp	affects,are
R5693	T8166	T8164	prep	of,Loss
R5694	T8167	T8166	pobj	Tbx15,of
R5695	T8169	T8170	amod	dorsoventral,transitions
R5696	T8170	T8165	dobj	transitions,affects
R5697	T8171	T8170	prep	of,transitions
R5698	T8172	T8173	compound	hair,length
R5699	T8173	T8171	pobj	length,of
R5700	T8174	T8170	punct	", ",transitions
R5701	T8175	T8176	compound	pigment,content
R5702	T8176	T8170	conj	content,transitions
R5703	T8177	T8176	punct	", ",content
R5704	T8178	T8176	cc	and,content
R5705	T8179	T8176	conj	expression,content
R5706	T8180	T8179	prep	of,expression
R5707	T8181	T8182	det	the,isoform
R5708	T8182	T8180	pobj	isoform,of
R5709	T8183	T8184	amod	ventral,specific
R5710	T8184	T8182	amod	specific,isoform
R5711	T8185	T8184	punct	-,specific
R5712	T8186	T8182	compound	Agouti,isoform
R5713	T8187	T8168	punct	;,are
R5714	T8188	T8168	advmod	however,are
R5715	T8189	T8168	punct	", ",are
R5716	T8190	T8191	det	the,effects
R5717	T8191	T8168	nsubj	effects,are
R5718	T8192	T8191	amod	former,effects
R5719	T8193	T8191	nummod	two,effects
R5720	T8194	T8168	acomp	subtle,are
R5721	T8195	T8168	cc	and,are
R5722	T8196	T8168	conj	contribute,are
R5723	T8197	T8196	dobj	little,contribute
R5724	T8198	T8199	punct	", ",all
R5725	T8199	T8197	parataxis	all,little
R5726	T8200	T8199	mark	if,all
R5727	T8201	T8199	advmod	at,all
R5728	T8202	T8199	punct	", ",all
R5729	T8203	T8196	prep	to,contribute
R5730	T8204	T8205	det	the,pigmentation
R5731	T8205	T8203	pobj	pigmentation,to
R5732	T8206	T8205	amod	abnormal,pigmentation
R5733	T8207	T8205	prep	of,pigmentation
R5734	T8208	T8209	amod	adult,mice
R5735	T8209	T8207	pobj	mice,of
R5736	T8210	T8211	nmod	deH,deH
R5737	T8211	T8209	compound	deH,mice
R5738	T8212	T8211	punct	/,deH
R5739	T8213	T8168	punct	.,are
R5740	T8215	T8216	advmod	Thus,is
R5741	T8217	T8216	punct	", ",is
R5742	T8218	T8216	prep	despite,is
R5743	T8219	T8220	det	the,pattern
R5744	T8220	T8218	pobj	pattern,despite
R5745	T8221	T8220	amod	abnormal,pattern
R5746	T8222	T8220	prep	of,pattern
R5747	T8223	T8224	amod	dark,skin
R5748	T8224	T8222	pobj	skin,of
R5749	T8225	T8220	prep	in,pattern
R5750	T8226	T8227	amod	neonatal,mice
R5751	T8227	T8225	pobj	mice,in
R5752	T8228	T8229	nmod	deH,deH
R5753	T8229	T8227	compound	deH,mice
R5754	T8230	T8229	punct	/,deH
R5755	T8231	T8232	punct	(,Figure
R5756	T8232	T8220	parataxis	Figure,pattern
R5757	T8233	T8232	advmod	e.g.,Figure
R5758	T8234	T8232	punct	", ",Figure
R5759	T8235	T8232	nummod	2D,Figure
R5760	T8236	T8232	punct	),Figure
R5761	T8237	T8216	punct	", ",is
R5762	T8238	T8239	det	the,feature
R5763	T8239	T8216	nsubj	feature,is
R5764	T8240	T8241	advmod	most,obvious
R5765	T8241	T8239	amod	obvious,feature
R5766	T8242	T8239	prep	in,feature
R5767	T8243	T8242	pobj	adults,in
R5768	T8244	T8245	amod	dorsal,displacement
R5769	T8245	T8216	attr	displacement,is
R5770	T8246	T8245	prep	of,displacement
R5771	T8247	T8248	det	the,boundary
R5772	T8248	T8246	pobj	boundary,of
R5773	T8249	T8248	punct	“,boundary
R5774	T8250	T8248	punct	”,boundary
R5775	T8251	T8248	prep	between,boundary
R5776	T8252	T8253	amod	black,hair
R5777	T8253	T8251	pobj	hair,between
R5778	T8254	T8252	cc	and,black
R5779	T8255	T8252	conj	yellow,black
R5780	T8256	T8257	punct	(,Figure
R5781	T8257	T8216	parataxis	Figure,is
R5782	T8258	T8257	nummod	9A,Figure
R5783	T8259	T8257	punct	),Figure
R5784	T8260	T8216	punct	.,is
R5787	T8497	T8496	prep	of,Genetics
R5788	T8498	T8497	pobj	Tbx15,of
R5789	T8500	T8501	advcl	Named,identified
R5790	T8502	T8500	prep	for,Named
R5791	T8503	T8504	det	the,presence
R5792	T8504	T8502	pobj	presence,for
R5793	T8505	T8504	prep	of,presence
R5794	T8506	T8507	det	a,domain
R5795	T8507	T8505	pobj	domain,of
R5796	T8508	T8509	npadvmod	DNA,binding
R5797	T8509	T8507	amod	binding,domain
R5798	T8510	T8509	punct	-,binding
R5799	T8511	T8512	advmod	first,identified
R5800	T8512	T8507	acl	identified,domain
R5801	T8513	T8512	prep	in,identified
R5802	T8514	T8515	det	the,gene
R5803	T8515	T8513	pobj	gene,in
R5804	T8516	T8515	compound	mouse,gene
R5805	T8517	T8515	compound	Brachyury,gene
R5806	T8518	T8519	punct	(,causes
R5807	T8519	T8500	parataxis	causes,Named
R5808	T8520	T8519	nsubj	haploinsufficiency,causes
R5809	T8521	T8522	det	a,tail
R5810	T8522	T8519	dobj	tail,causes
R5811	T8523	T8522	amod	short,tail
R5812	T8524	T8519	punct	),causes
R5813	T8525	T8501	punct	", ",identified
R5814	T8526	T8527	compound	T,box
R5815	T8527	T8528	npadvmod	box,containing
R5816	T8528	T8530	amod	containing,genes
R5817	T8529	T8528	punct	–,containing
R5818	T8530	T8501	nsubjpass	genes,identified
R5819	T8531	T8501	aux	have,identified
R5820	T8532	T8501	auxpass	been,identified
R5821	T8533	T8501	prep	as,identified
R5822	T8534	T8535	amod	developmental,regulators
R5823	T8535	T8533	pobj	regulators,as
R5824	T8536	T8501	prep	in,identified
R5825	T8537	T8538	det	a,spectrum
R5826	T8538	T8536	pobj	spectrum,in
R5827	T8539	T8538	amod	wide,spectrum
R5828	T8540	T8538	prep	of,spectrum
R5829	T8541	T8540	pobj	tissues,of
R5830	T8542	T8541	cc	and,tissues
R5831	T8543	T8544	amod	multicellular,organisms
R5832	T8544	T8541	conj	organisms,tissues
R5833	T8545	T8546	punct	(,reviewed
R5834	T8546	T8501	parataxis	reviewed,identified
R5835	T8547	T8546	prep	in,reviewed
R5836	T8548	T8547	pobj	Papaioannou,in
R5837	T8549	T8548	npadvmod	2001,Papaioannou
R5838	T8550	T8546	punct	),reviewed
R5839	T8551	T8501	punct	.,identified
R5840	T8553	T8554	det	The,subfamily
R5841	T8554	T8556	nsubj	subfamily,is
R5842	T8555	T8554	compound	Tbx15,subfamily
R5843	T8557	T8554	punct	", ",subfamily
R5844	T8558	T8559	dep	which,includes
R5845	T8559	T8554	relcl	includes,subfamily
R5846	T8560	T8559	advmod	also,includes
R5847	T8561	T8559	dobj	Tbx18,includes
R5848	T8562	T8561	cc	and,Tbx18
R5849	T8563	T8561	conj	Tbx22,Tbx18
R5850	T8564	T8556	punct	", ",is
R5851	T8565	T8556	acomp	likely,is
R5852	T8566	T8567	aux	to,arisen
R5853	T8567	T8565	xcomp	arisen,likely
R5854	T8568	T8567	aux	have,arisen
R5855	T8569	T8567	prep	during,arisen
R5856	T8570	T8571	amod	early,evolution
R5857	T8571	T8569	pobj	evolution,during
R5858	T8572	T8571	compound	chordate,evolution
R5859	T8573	T8574	mark	since,is
R5860	T8574	T8567	advcl	is,arisen
R5861	T8575	T8574	expl	there,is
R5862	T8576	T8577	det	a,gene
R5863	T8577	T8574	attr	gene,is
R5864	T8578	T8577	amod	single,gene
R5865	T8579	T8577	prep	in,gene
R5866	T8580	T8579	pobj	amphioxus,in
R5867	T8581	T8577	cc	but,gene
R5868	T8582	T8583	det	no,homolog
R5869	T8583	T8577	conj	homolog,gene
R5870	T8584	T8583	amod	obvious,homolog
R5871	T8585	T8583	prep	in,homolog
R5872	T8586	T8587	det	the,genome
R5873	T8587	T8585	pobj	genome,in
R5874	T8588	T8587	compound	fly,genome
R5875	T8589	T8590	punct	(,Ruvinsky
R5876	T8590	T8574	meta	Ruvinsky,is
R5877	T8591	T8590	nmod	et,Ruvinsky
R5878	T8592	T8590	nmod	al.,Ruvinsky
R5879	T8593	T8590	nummod	2000,Ruvinsky
R5880	T8594	T8590	punct	),Ruvinsky
R5881	T8595	T8556	punct	.,is
R5882	T8597	T8598	advcl	Consistent,expressed
R5883	T8599	T8597	prep	with,Consistent
R5884	T8600	T8601	det	this,relationship
R5885	T8601	T8599	pobj	relationship,with
R5886	T8602	T8598	punct	", ",expressed
R5887	T8603	T8604	det	the,genes
R5888	T8604	T8598	nsubjpass	genes,expressed
R5889	T8605	T8604	nummod	three,genes
R5890	T8606	T8598	auxpass	are,expressed
R5891	T8607	T8598	prep	in,expressed
R5892	T8608	T8609	advmod	partially,overlapping
R5893	T8609	T8610	amod	overlapping,patterns
R5894	T8610	T8607	pobj	patterns,in
R5895	T8611	T8612	dep	that,include
R5896	T8612	T8610	relcl	include,patterns
R5897	T8613	T8614	amod	anterior,somites
R5898	T8614	T8612	dobj	somites,include
R5899	T8615	T8616	punct	(,Tbx18
R5900	T8616	T8614	parataxis	Tbx18,somites
R5901	T8617	T8616	cc	and,Tbx18
R5902	T8618	T8616	conj	Tbx22,Tbx18
R5903	T8619	T8616	punct	),Tbx18
R5904	T8620	T8614	punct	", ",somites
R5905	T8621	T8622	compound	limb,mesenchyme
R5906	T8622	T8614	conj	mesenchyme,somites
R5907	T8623	T8624	punct	(,Tbx15
R5908	T8624	T8622	parataxis	Tbx15,mesenchyme
R5909	T8625	T8624	cc	and,Tbx15
R5910	T8626	T8624	conj	Tbx18,Tbx15
R5911	T8627	T8624	punct	),Tbx15
R5912	T8628	T8622	punct	", ",mesenchyme
R5913	T8629	T8622	cc	and,mesenchyme
R5914	T8630	T8631	amod	craniofacial,mesenchyme
R5915	T8631	T8622	conj	mesenchyme,mesenchyme
R5916	T8632	T8633	punct	(,genes
R5917	T8633	T8631	parataxis	genes,mesenchyme
R5918	T8634	T8633	det	all,genes
R5919	T8635	T8633	nummod	three,genes
R5920	T8636	T8633	punct	", ",genes
R5921	T8637	T8633	dep	Tbx15,genes
R5922	T8638	T8639	advmod	more,broadly
R5923	T8639	T8637	advmod	broadly,Tbx15
R5924	T8640	T8639	prep	than,broadly
R5925	T8641	T8640	pobj	Tbx18,than
R5926	T8642	T8641	cc	or,Tbx18
R5927	T8643	T8641	conj	Tbx22,Tbx18
R5928	T8644	T8633	punct	),genes
R5929	T8645	T8646	punct	(,Agulnik
R5930	T8646	T8612	meta	Agulnik,include
R5931	T8647	T8646	nmod	et,Agulnik
R5932	T8648	T8646	nmod	al.,Agulnik
R5933	T8649	T8646	nummod	1998,Agulnik
R5934	T8650	T8646	punct	;,Agulnik
R5935	T8651	T8646	nmod	Kraus,Agulnik
R5936	T8652	T8646	nmod	et,Agulnik
R5937	T8653	T8646	nmod	al.,Agulnik
R5938	T8654	T8646	nummod	2001,Agulnik
R5939	T8655	T8646	punct	;,Agulnik
R5940	T8656	T8646	nmod	Braybrook,Agulnik
R5941	T8657	T8646	nmod	et,Agulnik
R5942	T8658	T8646	nmod	al.,Agulnik
R5943	T8659	T8646	nummod	2002,Agulnik
R5944	T8660	T8646	punct	;,Agulnik
R5945	T8661	T8646	nmod	Bush,Agulnik
R5946	T8662	T8646	nmod	et,Agulnik
R5947	T8663	T8646	nmod	al.,Agulnik
R5948	T8664	T8646	nummod	2002,Agulnik
R5949	T8665	T8646	punct	;,Agulnik
R5950	T8666	T8646	nmod	Herr,Agulnik
R5951	T8667	T8646	nmod	et,Agulnik
R5952	T8668	T8646	nmod	al.,Agulnik
R5953	T8669	T8646	nummod	2003,Agulnik
R5954	T8670	T8646	punct	),Agulnik
R5955	T8671	T8598	punct	.,expressed
R5956	T8673	T8674	det	These,observations
R5957	T8674	T8675	nsubj	observations,suggest
R5958	T8676	T8677	mark	that,been
R5960	T8678	T8679	det	an,gene
R5961	T8679	T8677	nsubj	gene,been
R5962	T8680	T8679	amod	ancestral,gene
R5963	T8681	T8679	prep	for,gene
R5964	T8682	T8681	pobj	Tbx15,for
R5965	T8683	T8682	punct	", ",Tbx15
R5966	T8684	T8682	conj	Tbx18,Tbx15
R5967	T8685	T8684	punct	", ",Tbx18
R5968	T8686	T8684	cc	and,Tbx18
R5969	T8687	T8684	conj	Tbx22,Tbx18
R5970	T8688	T8677	aux	may,been
R5971	T8689	T8677	aux	have,been
R5972	T8690	T8677	acomp	important,been
R5973	T8691	T8677	prep	for,been
R5974	T8692	T8693	amod	craniofacial,development
R5975	T8693	T8691	pobj	development,for
R5976	T8694	T8693	prep	in,development
R5977	T8695	T8694	pobj	cephalochordates,in
R5978	T8696	T8677	punct	", ",been
R5979	T8697	T8677	prep	with,been
R5980	T8698	T8697	pobj	acquisition,with
R5981	T8699	T8698	prep	of,acquisition
R5982	T8700	T8701	amod	additional,patterns
R5983	T8701	T8699	pobj	patterns,of
R5984	T8702	T8701	compound	expression,patterns
R5985	T8703	T8701	cc	and,patterns
R5986	T8704	T8705	amod	developmental,functions
R5987	T8705	T8701	conj	functions,patterns
R5988	T8706	T8698	prep	in,acquisition
R5989	T8707	T8708	det	the,limb
R5990	T8708	T8706	pobj	limb,in
R5991	T8709	T8708	cc	and,limb
R5992	T8710	T8711	det	the,trunk
R5993	T8711	T8708	conj	trunk,limb
R5994	T8712	T8698	prep	during,acquisition
R5995	T8713	T8714	amod	early,evolution
R5996	T8714	T8712	pobj	evolution,during
R5997	T8715	T8714	compound	vertebrate,evolution
R5998	T8716	T8675	punct	.,suggest
R5999	T8718	T8719	nsubjpass	Expression,reported
R6000	T8720	T8718	prep	of,Expression
R6001	T8721	T8720	pobj	Tbx18,of
R6002	T8722	T8721	cc	and,Tbx18
R6003	T8723	T8721	conj	Tbx22,Tbx18
R6004	T8724	T8719	aux	has,reported
R6005	T8725	T8719	neg	not,reported
R6006	T8726	T8719	auxpass	been,reported
R6007	T8727	T8719	prep	in,reported
R6008	T8728	T8729	amod	embryonic,mesenchyme
R6009	T8729	T8727	pobj	mesenchyme,in
R6010	T8730	T8729	compound	flank,mesenchyme
R6011	T8731	T8719	punct	", ",reported
R6012	T8732	T8733	dep	which,suggests
R6013	T8733	T8719	advcl	suggests,reported
R6014	T8734	T8735	mark	that,is
R6015	T8735	T8733	ccomp	is,suggests
R6016	T8736	T8735	nsubj	Tbx15,is
R6017	T8737	T8738	det	the,member
R6018	T8738	T8735	attr	member,is
R6019	T8739	T8738	amod	only,member
R6020	T8740	T8738	compound	family,member
R6021	T8741	T8738	acl	involved,member
R6022	T8742	T8741	prep	in,involved
R6023	T8743	T8742	pcomp	establishing,in
R6024	T8744	T8745	det	the,identity
R6025	T8745	T8743	dobj	identity,establishing
R6026	T8746	T8745	amod	dorsoventral,identity
R6027	T8747	T8745	prep	of,identity
R6028	T8748	T8749	det	the,trunk
R6029	T8749	T8747	pobj	trunk,of
R6030	T8750	T8719	punct	.,reported
R6031	T8752	T8753	advmod	However,be
R6032	T8754	T8753	punct	", ",be
R6033	T8755	T8753	nsubj	it,be
R6034	T8756	T8753	aux	would,be
R6035	T8757	T8753	neg	not,be
R6036	T8758	T8753	acomp	surprising,be
R6037	T8759	T8760	aux	to,find
R6038	T8760	T8753	xcomp	find,be
R6039	T8761	T8762	det	some,degree
R6040	T8762	T8760	dobj	degree,find
R6041	T8763	T8762	prep	of,degree
R6042	T8764	T8765	amod	functional,redundancy
R6043	T8765	T8763	pobj	redundancy,of
R6044	T8766	T8760	prep	in,find
R6045	T8767	T8766	pobj	animals,in
R6046	T8768	T8767	acl	mutated,animals
R6047	T8769	T8768	prep	for,mutated
R6048	T8770	T8769	pobj	two,for
R6049	T8771	T8770	cc	or,two
R6050	T8772	T8770	conj	three,two
R6051	T8773	T8770	prep	of,two
R6052	T8774	T8775	det	the,members
R6053	T8775	T8773	pobj	members,of
R6054	T8776	T8775	compound	subfamily,members
R6055	T8777	T8760	prep	in,find
R6056	T8778	T8779	amod	other,regions
R6057	T8779	T8777	pobj	regions,in
R6058	T8780	T8779	compound	body,regions
R6059	T8781	T8779	punct	", ",regions
R6060	T8782	T8783	advmod	particularly,limbs
R6061	T8783	T8779	appos	limbs,regions
R6062	T8784	T8783	det	the,limbs
R6063	T8785	T8783	cc	and,limbs
R6064	T8786	T8787	det	the,head
R6065	T8787	T8783	conj	head,limbs
R6066	T8788	T8753	punct	.,be
R6067	T8790	T8791	prep	For,cause
R6068	T8792	T8790	pobj	example,For
R6069	T8793	T8791	punct	", ",cause
R6070	T8794	T8791	nsubj	mutations,cause
R6071	T8795	T8794	prep	in,mutations
R6072	T8796	T8795	pobj	Tbx22,in
R6073	T8797	T8798	det	the,syndrome
R6074	T8798	T8791	dobj	syndrome,cause
R6075	T8799	T8798	amod	human,syndrome
R6076	T8800	T8801	npadvmod	X,linked
R6077	T8801	T8803	amod	linked,palate
R6078	T8802	T8801	punct	-,linked
R6079	T8803	T8798	appos	palate,syndrome
R6080	T8804	T8803	amod	cleft,palate
R6081	T8805	T8803	cc	and,palate
R6082	T8806	T8803	conj	ankyloglossia,palate
R6083	T8807	T8808	punct	(,Braybrook
R6084	T8808	T8791	meta	Braybrook,cause
R6085	T8809	T8808	nmod	et,Braybrook
R6086	T8810	T8808	nmod	al.,Braybrook
R6087	T8811	T8808	nummod	2001,Braybrook
R6088	T8812	T8808	punct	),Braybrook
R6089	T8813	T8791	punct	.,cause
R6090	T8815	T8816	prep	Despite,affect
R6091	T8817	T8818	amod	high,levels
R6092	T8818	T8815	pobj	levels,Despite
R6093	T8819	T8818	prep	of,levels
R6094	T8820	T8821	compound	Tbx22,expression
R6095	T8821	T8819	pobj	expression,of
R6096	T8822	T8818	prep	in,levels
R6097	T8823	T8824	amod	periocular,mesenchyme
R6098	T8824	T8822	pobj	mesenchyme,in
R6099	T8825	T8824	amod	embryonic,mesenchyme
R6100	T8826	T8827	punct	(,Braybrook
R6101	T8827	T8818	meta	Braybrook,levels
R6102	T8828	T8827	nmod	et,Braybrook
R6103	T8829	T8827	nmod	al.,Braybrook
R6104	T8830	T8827	nummod	2002,Braybrook
R6105	T8831	T8827	punct	;,Braybrook
R6106	T8832	T8827	nmod	Bush,Braybrook
R6107	T8833	T8827	nmod	et,Braybrook
R6108	T8834	T8827	nmod	al.,Braybrook
R6109	T8835	T8827	nummod	2002,Braybrook
R6110	T8836	T8827	punct	;,Braybrook
R6111	T8837	T8827	nmod	Herr,Braybrook
R6112	T8838	T8827	nmod	et,Braybrook
R6113	T8839	T8827	nmod	al.,Braybrook
R6114	T8840	T8827	nummod	2003,Braybrook
R6115	T8841	T8827	punct	),Braybrook
R6116	T8842	T8816	punct	", ",affect
R6117	T8843	T8844	det	the,condition
R6118	T8844	T8816	nsubj	condition,affect
R6119	T8845	T8816	aux	does,affect
R6120	T8846	T8816	neg	not,affect
R6121	T8847	T8848	det	the,eye
R6122	T8848	T8816	dobj	eye,affect
R6123	T8849	T8816	punct	", ",affect
R6124	T8850	T8851	advmod	perhaps,provided
R6125	T8851	T8816	advcl	provided,affect
R6126	T8852	T8851	mark	because,provided
R6127	T8853	T8854	amod	residual,activity
R6128	T8854	T8851	nsubjpass	activity,provided
R6129	T8855	T8851	auxpass	is,provided
R6130	T8856	T8851	agent	by,provided
R6131	T8857	T8856	pobj	Tbx15,by
R6132	T8858	T8851	prep	in,provided
R6133	T8859	T8860	det	the,region
R6134	T8860	T8858	pobj	region,in
R6135	T8861	T8860	amod	same,region
R6136	T8862	T8816	punct	.,affect
R6137	T8864	T8865	prep	In,suggested
R6138	T8866	T8867	det	an,description
R6139	T8867	T8864	pobj	description,In
R6140	T8868	T8867	amod	initial,description
R6141	T8869	T8867	prep	of,description
R6142	T8870	T8871	det	the,expression
R6143	T8871	T8869	pobj	expression,of
R6144	T8872	T8871	cc	and,expression
R6145	T8873	T8874	compound	map,location
R6146	T8874	T8871	conj	location,expression
R6147	T8875	T8871	prep	of,expression
R6148	T8876	T8877	compound	mouse,Tbx15
R6149	T8877	T8875	pobj	Tbx15,of
R6150	T8878	T8865	punct	", ",suggested
R6151	T8879	T8865	nsubj	Agulnik,suggested
R6152	T8880	T8881	advmod	et,al.
R6153	T8881	T8879	advmod	al.,Agulnik
R6154	T8882	T8879	punct	(,Agulnik
R6155	T8883	T8879	npadvmod	1998,Agulnik
R6156	T8884	T8879	punct	),Agulnik
R6157	T8885	T8886	amod	human,Tbx15
R6158	T8886	T8865	dobj	Tbx15,suggested
R6159	T8887	T8888	dep	that,lies
R6160	T8888	T8886	relcl	lies,Tbx15
R6161	T8889	T8888	prep	on,lies
R6162	T8890	T8891	compound	Chromosome,1p11.1
R6163	T8891	T8889	pobj	1p11.1,on
R6164	T8892	T8865	prep	as,suggested
R6165	T8893	T8894	det	a,candidate
R6166	T8894	T8892	pobj	candidate,as
R6167	T8895	T8894	prep	for,candidate
R6168	T8896	T8897	amod	acromegaloid,appearance
R6169	T8897	T8899	nmod	appearance,syndrome
R6170	T8898	T8897	amod	facial,appearance
R6171	T8899	T8895	pobj	syndrome,for
R6172	T8900	T8897	punct	(,appearance
R6173	T8901	T8897	appos	AFA,appearance
R6174	T8902	T8899	punct	),syndrome
R6175	T8903	T8899	punct	", ",syndrome
R6176	T8904	T8905	prep	for,is
R6177	T8905	T8899	relcl	is,syndrome
R6178	T8906	T8904	pobj	which,for
R6179	T8907	T8905	expl	there,is
R6180	T8908	T8909	det	a,score
R6181	T8909	T8905	attr	score,is
R6182	T8910	T8909	amod	weak,score
R6183	T8911	T8909	amod	positive,score
R6184	T8912	T8909	compound	LOD,score
R6185	T8913	T8909	prep	to,score
R6186	T8914	T8915	compound	Chromosome,1p
R6187	T8915	T8913	pobj	1p,to
R6188	T8916	T8917	punct	(,Hughes
R6189	T8917	T8905	meta	Hughes,is
R6190	T8918	T8917	nmod	et,Hughes
R6191	T8919	T8917	nmod	al.,Hughes
R6192	T8920	T8917	nummod	1985,Hughes
R6193	T8921	T8917	punct	),Hughes
R6194	T8922	T8865	punct	.,suggested
R6195	T8924	T8925	advmod	Originally,described
R6196	T8925	T8926	advcl	described,describe
R6197	T8927	T8925	prep	as,described
R6198	T8928	T8929	det	a,syndrome
R6199	T8929	T8927	pobj	syndrome,as
R6200	T8930	T8929	amod	rare,syndrome
R6201	T8931	T8932	amod	autosomal,dominant
R6202	T8932	T8929	amod	dominant,syndrome
R6203	T8933	T8932	punct	-,dominant
R6204	T8934	T8929	prep	with,syndrome
R6205	T8935	T8936	amod	progressive,coarsening
R6206	T8936	T8934	pobj	coarsening,with
R6207	T8937	T8936	amod	facial,coarsening
R6208	T8938	T8936	punct	", ",coarsening
R6209	T8939	T8936	conj	overgrowth,coarsening
R6210	T8940	T8939	prep	of,overgrowth
R6211	T8941	T8942	det	the,mucosa
R6212	T8942	T8940	pobj	mucosa,of
R6213	T8943	T8942	amod	intraoral,mucosa
R6214	T8944	T8939	punct	", ",overgrowth
R6215	T8945	T8939	cc	and,overgrowth
R6216	T8946	T8947	amod	large,hands
R6217	T8947	T8939	conj	hands,overgrowth
R6218	T8948	T8947	punct	", ",hands
R6219	T8949	T8947	amod	doughy,hands
R6220	T8950	T8926	punct	", ",describe
R6221	T8951	T8952	advmod	more,recent
R6222	T8952	T8953	amod	recent,reports
R6223	T8953	T8926	nsubj	reports,describe
R6224	T8954	T8953	compound	case,reports
R6225	T8955	T8926	dobj	macrosomia,describe
R6226	T8956	T8955	punct	", ",macrosomia
R6227	T8957	T8955	conj	macrocephaly,macrosomia
R6228	T8958	T8957	punct	", ",macrocephaly
R6229	T8959	T8957	cc	or,macrocephaly
R6230	T8960	T8957	conj	both,macrocephaly
R6231	T8961	T8955	cc	and,macrosomia
R6232	T8962	T8963	amod	generalized,hypertrichosis
R6233	T8963	T8955	conj	hypertrichosis,macrosomia
R6234	T8964	T8926	prep	with,describe
R6235	T8965	T8966	amod	progressive,coarsening
R6236	T8966	T8964	pobj	coarsening,with
R6237	T8967	T8968	punct	(,Dallapiccola
R6238	T8968	T8926	meta	Dallapiccola,describe
R6239	T8969	T8968	nmod	et,Dallapiccola
R6240	T8970	T8968	nmod	al.,Dallapiccola
R6241	T8971	T8968	nummod	1992,Dallapiccola
R6242	T8972	T8968	punct	;,Dallapiccola
R6243	T8973	T8968	nmod	Irvine,Dallapiccola
R6244	T8974	T8968	nmod	et,Dallapiccola
R6245	T8975	T8968	nmod	al.,Dallapiccola
R6246	T8976	T8968	nummod	1996,Dallapiccola
R6247	T8977	T8968	punct	;,Dallapiccola
R6248	T8978	T8968	nmod	da,Dallapiccola
R6249	T8979	T8968	nmod	Silva,Dallapiccola
R6250	T8980	T8968	nmod	et,Dallapiccola
R6251	T8981	T8968	nmod	al.,Dallapiccola
R6252	T8982	T8968	nummod	1998,Dallapiccola
R6253	T8983	T8968	punct	;,Dallapiccola
R6254	T8984	T8968	nmod	Zelante,Dallapiccola
R6255	T8985	T8968	nmod	et,Dallapiccola
R6256	T8986	T8968	nmod	al.,Dallapiccola
R6257	T8987	T8968	nummod	2000,Dallapiccola
R6258	T8988	T8968	punct	),Dallapiccola
R6259	T8989	T8926	punct	.,describe
R6260	T8991	T8992	det	The,phenotype
R6261	T8992	T8994	nsubj	phenotype,exhibits
R6262	T8993	T8992	compound	deH,phenotype
R6263	T8994	T8995	ccomp	exhibits,suggest
R6264	T8996	T8997	amod	little,overlap
R6265	T8997	T8994	dobj	overlap,exhibits
R6266	T8998	T8997	prep	with,overlap
R6267	T8999	T9000	det	these,features
R6268	T9000	T8998	pobj	features,with
R6269	T9001	T8995	punct	;,suggest
R6270	T9002	T8995	advmod	instead,suggest
R6271	T9003	T8995	punct	", ",suggest
R6272	T9004	T8995	nsubj	we,suggest
R6273	T9005	T9006	det	a,candidate
R6274	T9006	T9009	nsubj	candidate,be
R6275	T9007	T9008	advmod	more,likely
R6276	T9008	T9006	amod	likely,candidate
R6277	T9009	T8995	advcl	be,suggest
R6278	T9010	T9006	prep	for,candidate
R6279	T9011	T9010	pobj	mutations,for
R6280	T9012	T9011	prep	of,mutations
R6281	T9013	T9014	amod	human,TBX15
R6282	T9014	T9012	pobj	TBX15,of
R6283	T9015	T9009	aux	would,be
R6284	T9016	T9017	amod	frontofacionasal,syndrome
R6285	T9017	T9009	attr	syndrome,be
R6286	T9018	T9017	punct	", ",syndrome
R6287	T9019	T9020	det	an,condition
R6288	T9020	T9017	appos	condition,syndrome
R6289	T9021	T9020	amod	unmapped,condition
R6290	T9022	T9020	amod	autosomal,condition
R6291	T9023	T9020	amod	recessive,condition
R6292	T9024	T9020	acl	characterized,condition
R6293	T9025	T9024	agent	by,characterized
R6294	T9026	T9025	pobj	brachycephaly,by
R6295	T9027	T9026	punct	", ",brachycephaly
R6296	T9028	T9026	conj	blepharophimosis,brachycephaly
R6297	T9029	T9028	punct	", ",blepharophimosis
R6298	T9030	T9028	cc	and,blepharophimosis
R6299	T9031	T9032	amod	midface,hypoplasia
R6300	T9032	T9028	conj	hypoplasia,blepharophimosis
R6301	T9033	T9034	punct	(,Reardon
R6302	T9034	T9024	meta	Reardon,characterized
R6303	T9035	T9034	nmod	et,Reardon
R6304	T9036	T9034	nmod	al.,Reardon
R6305	T9037	T9034	nummod	1994,Reardon
R6306	T9038	T9034	punct	),Reardon
R6307	T9039	T8995	punct	.,suggest
R6308	T9041	T9042	nsubj	Two,became
R6309	T9043	T9041	prep	of,Two
R6310	T9044	T9043	pobj	us,of
R6311	T9045	T9041	punct	(,Two
R6312	T9046	T9047	compound	S.,Kuijper
R6313	T9047	T9041	appos	Kuijper,Two
R6314	T9048	T9047	cc	and,Kuijper
R6315	T9049	T9050	compound	F.,Meijlink
R6316	T9050	T9047	conj	Meijlink,Kuijper
R6317	T9051	T9042	punct	),became
R6318	T9052	T9042	acomp	interested,became
R6319	T9053	T9052	prep	in,interested
R6320	T9054	T9055	det	the,mutation
R6321	T9055	T9053	pobj	mutation,in
R6322	T9056	T9055	compound	deH,mutation
R6323	T9057	T9042	prep	because,became
R6324	T9058	T9057	pcomp	of,because
R6325	T9059	T9060	poss	its,effects
R6326	T9060	T9057	pobj	effects,because
R6327	T9061	T9060	prep	on,effects
R6328	T9062	T9063	amod	skeletal,development
R6329	T9063	T9061	pobj	development,on
R6330	T9064	T9065	punct	(,Curry
R6331	T9065	T9060	meta	Curry,effects
R6332	T9066	T9065	nummod	1959,Curry
R6333	T9067	T9065	punct	),Curry
R6334	T9068	T9060	cc	and,effects
R6335	T9069	T9070	det	the,possibility
R6336	T9070	T9060	conj	possibility,effects
R6337	T9071	T9072	mark	that,be
R6338	T9072	T9070	acl	be,possibility
R6339	T9073	T9074	det	the,gene
R6340	T9074	T9072	nsubj	gene,be
R6341	T9075	T9076	npadvmod	aristaless,related
R6342	T9076	T9074	amod	related,gene
R6343	T9077	T9076	punct	-,related
R6344	T9078	T9074	appos	Alx3,gene
R6345	T9079	T9072	aux	might,be
R6346	T9080	T9072	acomp	allelic,be
R6347	T9081	T9080	prep	with,allelic
R6348	T9082	T9083	amod	droopy,ear
R6349	T9083	T9081	pobj	ear,with
R6350	T9084	T9085	punct	(,ten
R6351	T9085	T9072	meta	ten,be
R6352	T9086	T9085	nmod	Berge,ten
R6353	T9087	T9085	nmod	et,ten
R6354	T9088	T9085	nmod	al.,ten
R6355	T9089	T9085	nummod	1998,ten
R6356	T9090	T9085	punct	),ten
R6357	T9091	T9042	punct	.,became
R6358	T9093	T9094	prep	In,excluded
R6359	T9095	T9093	pobj	spite,In
R6360	T9096	T9095	prep	of,spite
R6361	T9097	T9096	pobj	similarities,of
R6362	T9098	T9097	prep	between,similarities
R6363	T9099	T9100	amod	skeletal,phenotypes
R6364	T9100	T9098	pobj	phenotypes,between
R6365	T9101	T9100	prep	of,phenotypes
R6366	T9102	T9103	nmod	deH,mutants
R6367	T9103	T9101	pobj	mutants,of
R6368	T9104	T9102	cc	and,deH
R6369	T9105	T9102	conj	Alx3,deH
R6370	T9106	T9105	cc	or,Alx3
R6371	T9107	T9105	conj	Alx4,Alx3
R6372	T9108	T9094	punct	", ",excluded
R6373	T9109	T9110	amod	subsequent,experiments
R6374	T9110	T9094	nsubj	experiments,excluded
R6375	T9111	T9112	punct	(,data
R6376	T9112	T9110	meta	data,experiments
R6377	T9113	T9112	amod	unpublished,data
R6378	T9114	T9112	punct	),data
R6379	T9115	T9094	dobj	allelism,excluded
R6380	T9116	T9115	prep	of,allelism
R6381	T9117	T9116	pobj	Alx3,of
R6382	T9118	T9117	cc	and,Alx3
R6383	T9119	T9117	conj	deH,Alx3
R6384	T9120	T9094	punct	", ",excluded
R6385	T9121	T9094	cc	and,excluded
R6386	T9122	T9123	det	a,description
R6387	T9123	T9125	nsubjpass	description,published
R6388	T9124	T9123	amod	full,description
R6389	T9125	T9094	conj	published,excluded
R6390	T9126	T9123	prep	of,description
R6391	T9127	T9128	det	the,phenotype
R6392	T9128	T9126	pobj	phenotype,of
R6393	T9129	T9128	nmod	Tbx15,phenotype
R6394	T9130	T9128	amod	skeletal,phenotype
R6395	T9131	T9125	aux	will,published
R6396	T9132	T9125	auxpass	be,published
R6397	T9133	T9125	advmod	elsewhere,published
R6398	T9134	T9094	punct	.,excluded
R6406	T9366	T9367	amod	Developmental,Mechanism
R6407	T9368	T9367	prep	of,Mechanism
R6408	T9369	T9370	compound	Tbx15,Expression
R6409	T9370	T9368	pobj	Expression,of
R6410	T9371	T9370	cc	and,Expression
R6411	T9372	T9370	conj	Action,Expression
R6412	T9373	T9370	prep	in,Expression
R6413	T9374	T9375	det	the,Skin
R6414	T9375	T9373	pobj	Skin,in
R6415	T9377	T9378	poss	Our,attention
R6416	T9378	T9379	nsubjpass	attention,motivated
R6417	T9380	T9378	prep	to,attention
R6418	T9381	T9382	det	the,role
R6419	T9382	T9380	pobj	role,to
R6420	T9383	T9382	prep	of,role
R6421	T9384	T9383	pobj	Tbx15,of
R6422	T9385	T9382	prep	in,role
R6423	T9386	T9387	compound	pigment,patterning
R6424	T9387	T9385	pobj	patterning,in
R6425	T9388	T9379	auxpass	was,motivated
R6426	T9389	T9379	agent	by,motivated
R6427	T9390	T9391	det	the,effects
R6428	T9391	T9389	pobj	effects,by
R6429	T9392	T9391	prep	of,effects
R6430	T9393	T9392	pobj	Agouti,of
R6431	T9394	T9391	prep	in,effects
R6432	T9395	T9396	amod	postnatal,animals
R6433	T9396	T9394	pobj	animals,in
R6434	T9397	T9379	punct	.,motivated
R6435	T9399	T9400	advmod	However,expressed
R6436	T9401	T9400	punct	", ",expressed
R6437	T9402	T9400	nsubjpass	Agouti,expressed
R6438	T9403	T9400	auxpass	is,expressed
R6439	T9404	T9400	advmod	also,expressed
R6440	T9405	T9400	prep	in,expressed
R6441	T9406	T9407	det	the,embryo
R6442	T9407	T9405	pobj	embryo,in
R6443	T9408	T9407	punct	", ",embryo
R6444	T9409	T9410	advmod	where,provides
R6445	T9410	T9407	relcl	provides,embryo
R6446	T9411	T9410	nsubj	it,provides
R6447	T9412	T9413	det	a,marker
R6448	T9413	T9410	dobj	marker,provides
R6449	T9414	T9413	amod	convenient,marker
R6450	T9415	T9413	prep	of,marker
R6451	T9416	T9417	amod	ventral,identity
R6452	T9417	T9415	pobj	identity,of
R6453	T9418	T9417	compound	dermis,identity
R6454	T9419	T9400	punct	.,expressed
R6455	T9421	T9422	mark	Because,is
R6456	T9422	T9435	advcl	is,occur
R6457	T9423	T9424	det	an,domain
R6458	T9424	T9422	nsubj	domain,is
R6459	T9425	T9424	amod	expanded,domain
R6460	T9426	T9424	prep	of,domain
R6461	T9427	T9428	amod	embryonic,expression
R6462	T9428	T9426	pobj	expression,of
R6463	T9429	T9428	compound	Agouti,expression
R6464	T9430	T9424	prep	in,domain
R6465	T9431	T9432	compound	deH,deH
R6466	T9432	T9434	compound	deH,animals
R6467	T9433	T9432	punct	/,deH
R6468	T9434	T9430	pobj	animals,in
R6469	T9436	T9422	acomp	detectable,is
R6470	T9437	T9422	prep	by,is
R6471	T9438	T9437	pobj	E14.5,by
R6472	T9439	T9435	punct	", ",occur
R6473	T9440	T9441	det	the,effects
R6474	T9441	T9435	nsubj	effects,occur
R6475	T9442	T9441	prep	of,effects
R6476	T9443	T9442	pobj	Tbx15,of
R6477	T9444	T9441	prep	on,effects
R6478	T9445	T9446	amod	dorsoventral,patterning
R6479	T9446	T9444	pobj	patterning,on
R6480	T9447	T9435	aux	must,occur
R6481	T9448	T9435	advmod	prior,occur
R6482	T9449	T9448	prep	to,prior
R6483	T9450	T9451	det	this,time
R6484	T9451	T9449	pobj	time,to
R6485	T9452	T9435	punct	.,occur
R6486	T9454	T9455	prep	Among,emerged
R6487	T9456	T9457	amod	other,genes
R6488	T9457	T9454	pobj	genes,Among
R6489	T9458	T9459	compound	T,box
R6490	T9459	T9457	compound	box,genes
R6491	T9460	T9459	punct	-,box
R6492	T9461	T9462	poss	whose,actions
R6493	T9462	T9464	dep	actions,understood
R6494	T9463	T9462	amod	developmental,actions
R6495	T9464	T9457	relcl	understood,genes
R6496	T9465	T9464	auxpass	are,understood
R6497	T9466	T9467	advmod	at,least
R6498	T9467	T9468	advmod	least,partially
R6499	T9468	T9464	advmod	partially,understood
R6500	T9469	T9455	punct	", ",emerged
R6501	T9470	T9471	nummod	two,themes
R6502	T9471	T9455	nsubj	themes,emerged
R6503	T9472	T9471	amod	general,themes
R6504	T9473	T9455	aux	have,emerged
R6505	T9474	T9455	punct	", ",emerged
R6506	T9475	T9476	nsubj	one,focused
R6507	T9476	T9455	advcl	focused,emerged
R6508	T9477	T9476	prep	on,focused
R6509	T9478	T9479	det	the,ability
R6510	T9479	T9477	pobj	ability,on
R6511	T9480	T9481	aux	to,specify
R6512	T9481	T9479	acl	specify,ability
R6513	T9482	T9483	amod	alternative,fates
R6514	T9483	T9481	dobj	fates,specify
R6515	T9484	T9481	prep	for,specify
R6516	T9485	T9486	det	an,group
R6517	T9486	T9484	pobj	group,for
R6518	T9487	T9486	amod	undifferentiated,group
R6519	T9488	T9486	prep	of,group
R6520	T9489	T9490	compound	precursor,cells
R6521	T9490	T9488	pobj	cells,of
R6522	T9491	T9476	cc	and,focused
R6523	T9492	T9493	nsubj	another,focused
R6524	T9493	T9476	conj	focused,focused
R6525	T9494	T9493	prep	on,focused
R6526	T9495	T9496	det	the,ability
R6527	T9496	T9494	pobj	ability,on
R6528	T9497	T9498	aux	to,support
R6529	T9498	T9496	acl	support,ability
R6530	T9499	T9500	amod	proliferative,expansion
R6531	T9500	T9498	dobj	expansion,support
R6532	T9501	T9500	prep	of,expansion
R6533	T9502	T9503	det	a,population
R6534	T9503	T9501	pobj	population,of
R6535	T9504	T9503	compound	cell,population
R6536	T9505	T9506	poss	whose,fate
R6537	T9506	T9507	dep	fate,determined
R6538	T9507	T9503	relcl	determined,population
R6539	T9508	T9507	auxpass	is,determined
R6540	T9509	T9507	advmod	already,determined
R6541	T9510	T9511	punct	(,reviewed
R6542	T9511	T9493	parataxis	reviewed,focused
R6543	T9512	T9511	prep	in,reviewed
R6544	T9513	T9512	pobj	Tada,in
R6545	T9514	T9513	cc	and,Tada
R6546	T9515	T9513	conj	Smith,Tada
R6547	T9516	T9513	npadvmod	2001,Tada
R6548	T9517	T9511	punct	),reviewed
R6549	T9518	T9455	punct	.,emerged
R6550	T9520	T9521	det	Either,mechanism
R6551	T9521	T9522	nsubj	mechanism,apply
R6552	T9523	T9522	aux	may,apply
R6553	T9524	T9522	prep	to,apply
R6554	T9525	T9526	det	the,transformation
R6555	T9526	T9524	pobj	transformation,to
R6556	T9527	T9526	amod	apparent,transformation
R6557	T9528	T9526	amod	dorsal,transformation
R6558	T9529	T9528	punct	-,dorsal
R6559	T9530	T9528	prep	to,dorsal
R6560	T9531	T9530	punct	-,to
R6561	T9532	T9530	amod	ventral,to
R6562	T9533	T9526	prep	in,transformation
R6563	T9534	T9535	compound	deH,deH
R6564	T9535	T9537	compound	deH,mice
R6565	T9536	T9535	punct	/,deH
R6566	T9537	T9533	pobj	mice,in
R6567	T9538	T9522	punct	.,apply
R6568	T9540	T9541	prep	For,be
R6569	T9542	T9540	pobj	example,For
R6570	T9543	T9541	punct	", ",be
R6571	T9544	T9545	mark	while,traced
R6572	T9545	T9541	advcl	traced,be
R6573	T9546	T9547	det	the,domain
R6574	T9547	T9545	nsubjpass	domain,traced
R6575	T9548	T9547	amod	expanded,domain
R6576	T9549	T9547	prep	of,domain
R6577	T9550	T9551	compound	Agouti,expression
R6578	T9551	T9549	pobj	expression,of
R6579	T9552	T9547	prep	in,domain
R6580	T9553	T9554	amod	postnatal,animals
R6581	T9554	T9552	pobj	animals,in
R6582	T9555	T9556	compound	deH,deH
R6583	T9556	T9554	compound	deH,animals
R6584	T9557	T9556	punct	/,deH
R6585	T9558	T9545	aux	can,traced
R6586	T9559	T9545	auxpass	be,traced
R6587	T9560	T9545	prep	to,traced
R6588	T9561	T9560	pobj	events,to
R6589	T9562	T9563	dep	that,occur
R6590	T9563	T9561	relcl	occur,events
R6591	T9564	T9563	prep	between,occur
R6592	T9565	T9564	pobj	E11.5,between
R6593	T9566	T9565	cc	and,E11.5
R6594	T9567	T9565	conj	E13.5,E11.5
R6595	T9568	T9541	punct	", ",be
R6596	T9569	T9570	det	the,cause
R6597	T9570	T9541	nsubj	cause,be
R6598	T9571	T9570	amod	underlying,cause
R6599	T9572	T9541	aux	may,be
R6600	T9573	T9574	mark	that,acquire
R6601	T9574	T9541	advcl	acquire,be
R6602	T9575	T9576	amod	embryonic,cells
R6603	T9576	T9574	nsubj	cells,acquire
R6604	T9577	T9576	prep	in,cells
R6605	T9578	T9579	amod	dorsolateral,mesenchyme
R6606	T9579	T9577	pobj	mesenchyme,in
R6607	T9580	T9581	det	a,identity
R6608	T9581	T9574	dobj	identity,acquire
R6609	T9582	T9581	amod	ventral,identity
R6610	T9583	T9582	cc	rather,ventral
R6611	T9584	T9583	dep	than,rather
R6612	T9585	T9582	conj	dorsal,ventral
R6613	T9586	T9574	cc	or,acquire
R6614	T9587	T9588	mark	that,fail
R6615	T9588	T9574	conj	fail,acquire
R6616	T9589	T9590	det	those,cells
R6617	T9590	T9588	nsubj	cells,fail
R6618	T9591	T9592	aux	to,proliferate
R6619	T9592	T9588	xcomp	proliferate,fail
R6620	T9593	T9592	advmod	normally,proliferate
R6621	T9594	T9588	punct	", ",fail
R6622	T9595	T9588	advcl	followed,fail
R6623	T9596	T9595	agent	by,followed
R6624	T9597	T9598	amod	compensatory,expansion
R6625	T9598	T9596	pobj	expansion,by
R6626	T9599	T9598	prep	of,expansion
R6627	T9600	T9601	amod	ventral,cells
R6628	T9601	T9599	pobj	cells,of
R6629	T9602	T9541	punct	.,be
R6630	T9604	T9605	compound	Cell,lineage
R6631	T9605	T9606	compound	lineage,studies
R6632	T9606	T9607	nsubj	studies,provide
R6633	T9608	T9607	aux	should,provide
R6634	T9609	T9610	det	a,answer
R6635	T9610	T9607	dobj	answer,provide
R6636	T9611	T9610	amod	definitive,answer
R6637	T9612	T9607	punct	", ",provide
R6638	T9613	T9607	cc	but,provide
R6639	T9614	T9615	nsubj	we,favor
R6640	T9615	T9607	conj	favor,provide
R6641	T9616	T9617	det	the,hypothesis
R6642	T9617	T9615	dobj	hypothesis,favor
R6643	T9618	T9617	amod	latter,hypothesis
R6644	T9619	T9615	punct	", ",favor
R6645	T9620	T9621	mark	because,revealed
R6646	T9621	T9615	advcl	revealed,favor
R6647	T9622	T9621	nsubj	measurements,revealed
R6648	T9623	T9622	prep	of,measurements
R6649	T9624	T9625	amod	dorsoventral,regions
R6650	T9625	T9623	pobj	regions,of
R6651	T9626	T9622	prep	according,measurements
R6652	T9627	T9626	prep	to,according
R6653	T9628	T9629	compound	hair,color
R6654	T9629	T9627	pobj	color,to
R6655	T9630	T9629	prep	in,color
R6656	T9631	T9632	compound	deH,deH
R6657	T9632	T9634	compound	deH,mice
R6658	T9633	T9632	punct	/,deH
R6659	T9634	T9630	pobj	mice,in
R6660	T9635	T9636	det	a,increase
R6661	T9636	T9621	dobj	increase,revealed
R6662	T9637	T9636	amod	small,increase
R6663	T9638	T9636	prep	of,increase
R6664	T9639	T9640	det	the,region
R6665	T9640	T9638	pobj	region,of
R6666	T9641	T9642	amod	cream,colored
R6667	T9642	T9640	amod	colored,region
R6668	T9643	T9642	punct	-,colored
R6669	T9644	T9640	amod	ventral,region
R6670	T9645	T9621	prep	in,revealed
R6671	T9646	T9645	pobj	addition,in
R6672	T9647	T9646	prep	to,addition
R6673	T9648	T9649	det	the,doubling
R6674	T9649	T9647	pobj	doubling,to
R6675	T9650	T9649	amod	approximate,doubling
R6676	T9651	T9649	prep	of,doubling
R6677	T9652	T9653	det	the,region
R6678	T9653	T9651	pobj	region,of
R6679	T9654	T9653	amod	yellow,region
R6680	T9655	T9653	compound	flank,region
R6681	T9656	T9657	punct	(,see
R6682	T9657	T9621	parataxis	see,revealed
R6683	T9658	T9657	dobj	Figure,see
R6684	T9659	T9658	nummod	2,Figure
R6685	T9660	T9657	punct	),see
R6686	T9661	T9615	punct	.,favor
R6687	T9663	T9664	prep	In,are
R6688	T9665	T9666	amod	embryonic,mesenchyme
R6689	T9666	T9663	pobj	mesenchyme,In
R6690	T9667	T9664	punct	", ",are
R6691	T9668	T9664	nsubj	expression,are
R6692	T9669	T9668	prep	of,expression
R6693	T9670	T9669	pobj	Tbx15,of
R6694	T9671	T9670	cc	and,Tbx15
R6695	T9672	T9670	conj	Agouti,Tbx15
R6696	T9673	T9664	acomp	complementary,are
R6697	T9674	T9664	punct	", ",are
R6698	T9675	T9664	cc	and,are
R6699	T9676	T9677	nsubj	it,is
R6700	T9677	T9664	conj	is,are
R6701	T9678	T9677	acomp	possible,is
R6702	T9679	T9680	mark	that,acts
R6703	T9680	T9677	ccomp	acts,is
R6704	T9681	T9680	nsubj	Tbx15,acts
R6705	T9682	T9680	advmod	directly,acts
R6706	T9683	T9684	aux	to,inhibit
R6707	T9684	T9680	advcl	inhibit,acts
R6708	T9685	T9686	compound	Agouti,transcription
R6709	T9686	T9684	dobj	transcription,inhibit
R6710	T9687	T9684	prep	in,inhibit
R6711	T9688	T9689	amod	dorsolateral,mesenchyme
R6712	T9689	T9687	pobj	mesenchyme,in
R6713	T9690	T9664	punct	.,are
R6714	T9692	T9693	advmod	However,is
R6715	T9694	T9693	punct	", ",is
R6716	T9695	T9696	det	the,ability
R6717	T9696	T9693	nsubj	ability,is
R6718	T9697	T9696	prep	of,ability
R6719	T9698	T9697	pobj	Tbx15,of
R6720	T9699	T9700	aux	to,suppress
R6721	T9700	T9696	acl	suppress,ability
R6722	T9701	T9700	dobj	expression,suppress
R6723	T9702	T9701	prep	of,expression
R6724	T9703	T9704	det	the,isoform
R6725	T9704	T9702	pobj	isoform,of
R6726	T9705	T9706	amod	ventral,specific
R6727	T9706	T9704	amod	specific,isoform
R6728	T9707	T9706	punct	-,specific
R6729	T9708	T9704	compound	Agouti,isoform
R6730	T9709	T9700	prep	in,suppress
R6731	T9710	T9711	amod	postnatal,mice
R6732	T9711	T9709	pobj	mice,in
R6733	T9712	T9693	acomp	likely,is
R6734	T9713	T9714	aux	to,be
R6735	T9714	T9712	xcomp	be,likely
R6736	T9715	T9714	acomp	indirect,be
R6737	T9716	T9693	punct	", ",is
R6738	T9717	T9718	mark	since,occurs
R6739	T9718	T9693	advcl	occurs,is
R6740	T9719	T9720	amod	postnatal,expression
R6741	T9720	T9718	nsubj	expression,occurs
R6742	T9721	T9720	prep	of,expression
R6743	T9722	T9721	pobj	Tbx15,of
R6744	T9723	T9718	advmod	broadly,occurs
R6745	T9724	T9718	prep	along,occurs
R6746	T9725	T9726	det	the,axis
R6747	T9726	T9724	pobj	axis,along
R6748	T9727	T9726	amod	dorsoventral,axis
R6749	T9728	T9718	cc	and,occurs
R6750	T9729	T9718	conj	overlaps,occurs
R6751	T9730	T9729	advmod	extensively,overlaps
R6752	T9731	T9729	prep	with,overlaps
R6753	T9732	T9731	pobj	that,with
R6754	T9733	T9732	prep	of,that
R6755	T9734	T9733	pobj	Agouti,of
R6756	T9735	T9693	punct	.,is
R6757	T9737	T9738	prep	In,include
R6758	T9739	T9740	det	either,case
R6759	T9740	T9737	pobj	case,In
R6760	T9741	T9738	punct	", ",include
R6761	T9742	T9743	det	the,targets
R6762	T9743	T9738	nsubj	targets,include
R6763	T9744	T9743	prep	of,targets
R6764	T9745	T9746	compound	Tbx15,action
R6765	T9746	T9744	pobj	action,of
R6766	T9747	T9743	prep	in,targets
R6767	T9748	T9749	det	the,skin
R6768	T9749	T9747	pobj	skin,in
R6769	T9750	T9738	dobj	genes,include
R6770	T9751	T9738	prep	in,include
R6771	T9752	T9751	pobj	addition,in
R6772	T9753	T9752	prep	to,addition
R6773	T9754	T9753	pobj	Agouti,to
R6774	T9755	T9738	punct	", ",include
R6775	T9756	T9757	mark	since,exhibit
R6776	T9757	T9738	advcl	exhibit,include
R6777	T9758	T9759	compound	hair,length
R6778	T9759	T9757	nsubj	length,exhibit
R6779	T9760	T9759	cc	and,length
R6780	T9761	T9762	compound	melanocyte,distribution
R6781	T9762	T9759	conj	distribution,length
R6782	T9763	T9764	det	a,alteration
R6783	T9764	T9757	dobj	alteration,exhibit
R6784	T9765	T9764	amod	demonstrable,alteration
R6785	T9766	T9765	punct	", ",demonstrable
R6786	T9767	T9765	cc	albeit,demonstrable
R6787	T9768	T9765	conj	subtle,demonstrable
R6788	T9769	T9764	punct	", ",alteration
R6789	T9770	T9757	prep	in,exhibit
R6790	T9771	T9770	pobj	animals,in
R6791	T9772	T9773	dep	that,carry
R6792	T9773	T9771	relcl	carry,animals
R6793	T9774	T9775	det	a,allele
R6794	T9775	T9773	dobj	allele,carry
R6795	T9776	T9775	amod	null,allele
R6796	T9777	T9775	compound	Agouti,allele
R6797	T9778	T9738	punct	.,include
R6798	T9780	T9781	nummod	One,target
R6799	T9781	T9783	nsubj	target,is
R6800	T9782	T9781	amod	potential,target
R6801	T9784	T9783	attr	Alx4,is
R6802	T9785	T9784	punct	", ",Alx4
R6803	T9786	T9787	dep	which,expressed
R6804	T9787	T9784	relcl	expressed,Alx4
R6805	T9788	T9787	punct	", ",expressed
R6806	T9789	T9787	prep	like,expressed
R6807	T9790	T9789	pobj	Agouti,like
R6808	T9791	T9787	punct	", ",expressed
R6809	T9792	T9787	auxpass	is,expressed
R6810	T9793	T9787	prep	in,expressed
R6811	T9794	T9795	amod	ventral,mesenchyme
R6812	T9795	T9793	pobj	mesenchyme,in
R6813	T9796	T9795	amod	embryonic,mesenchyme
R6814	T9797	T9787	punct	", ",expressed
R6815	T9798	T9787	cc	and,expressed
R6816	T9799	T9787	punct	", ",expressed
R6817	T9800	T9801	advmod	when,mutated
R6818	T9801	T9802	advcl	mutated,affects
R6819	T9802	T9787	conj	affects,expressed
R6820	T9803	T9802	punct	", ",affects
R6821	T9804	T9805	nmod	hair,follicle
R6822	T9805	T9807	nmod	follicle,development
R6823	T9806	T9805	punct	-,follicle
R6824	T9807	T9802	dobj	development,affects
R6825	T9808	T9809	advmod	as,as
R6826	T9809	T9805	cc	as,follicle
R6827	T9810	T9809	advmod	well,as
R6828	T9811	T9805	conj	limb,follicle
R6829	T9812	T9811	cc	and,limb
R6830	T9813	T9811	conj	craniofacial,limb
R6831	T9814	T9815	punct	(,Qu
R6832	T9815	T9783	meta	Qu,is
R6833	T9816	T9815	nmod	et,Qu
R6834	T9817	T9815	nmod	al.,Qu
R6835	T9818	T9815	nummod	1997,Qu
R6836	T9819	T9815	punct	", ",Qu
R6837	T9820	T9815	nummod	1998,Qu
R6838	T9821	T9815	punct	;,Qu
R6839	T9822	T9815	nmod	Wu,Qu
R6840	T9823	T9815	nmod	et,Qu
R6841	T9824	T9815	nmod	al.,Qu
R6842	T9825	T9815	nummod	2000,Qu
R6843	T9826	T9815	punct	;,Qu
R6844	T9827	T9815	nmod	Wuyts,Qu
R6845	T9828	T9815	nmod	et,Qu
R6846	T9829	T9815	nmod	al.,Qu
R6847	T9830	T9815	nummod	2000,Qu
R6848	T9831	T9815	punct	;,Qu
R6849	T9832	T9815	nmod	Mavrogiannis,Qu
R6850	T9833	T9815	nmod	et,Qu
R6851	T9834	T9815	nmod	al.,Qu
R6852	T9835	T9815	nummod	2001,Qu
R6853	T9836	T9815	punct	),Qu
R6854	T9837	T9783	punct	.,is
R6855	T9839	T9840	advmod	However,appears
R6856	T9841	T9840	punct	", ",appears
R6857	T9842	T9840	nsubj	expression,appears
R6858	T9843	T9842	prep	of,expression
R6859	T9844	T9845	amod	ventral,markers
R6860	T9845	T9843	pobj	markers,of
R6861	T9846	T9847	amod	such,as
R6862	T9847	T9845	prep	as,markers
R6863	T9848	T9847	pobj	Alx4,as
R6864	T9849	T9848	punct	", ",Alx4
R6865	T9850	T9851	advmod	as,as
R6866	T9851	T9848	cc	as,Alx4
R6867	T9852	T9851	advmod	well,as
R6868	T9853	T9848	conj	Alx3,Alx4
R6869	T9854	T9853	cc	and,Alx3
R6870	T9855	T9853	conj	Msx2,Alx3
R6871	T9856	T9840	punct	", ",appears
R6872	T9857	T9858	aux	to,be
R6873	T9858	T9840	xcomp	be,appears
R6874	T9859	T9858	acomp	unaffected,be
R6875	T9860	T9858	prep	at,be
R6876	T9861	T9860	pobj	E11.5,at
R6877	T9862	T9858	prep	in,be
R6878	T9863	T9864	compound	deH,deH
R6879	T9864	T9866	compound	deH,embryos
R6880	T9865	T9864	punct	/,deH
R6881	T9866	T9862	pobj	embryos,in
R6882	T9867	T9868	punct	(,shown
R6883	T9868	T9858	parataxis	shown,be
R6884	T9869	T9868	nsubj	data,shown
R6885	T9870	T9868	neg	not,shown
R6886	T9871	T9868	punct	),shown
R6887	T9872	T9840	punct	.,appears
R6896	T10220	T10219	cc	and,Differences
R6897	T10221	T10219	conj	Similarities,Differences
R6898	T10222	T10219	prep	to,Differences
R6899	T10223	T10224	amod	Dorsoventral,Patterning
R6900	T10224	T10222	pobj	Patterning,to
R6901	T10225	T10224	compound	Limb,Patterning
R6902	T10227	T10228	nsubj	Loss,affects
R6903	T10229	T10227	prep	of,Loss
R6904	T10230	T10229	pobj	Tbx15,of
R6905	T10231	T10228	advmod	also,affects
R6906	T10232	T10233	amod	regional,distribution
R6907	T10233	T10228	dobj	distribution,affects
R6908	T10234	T10233	prep	of,distribution
R6909	T10235	T10236	compound	hair,color
R6910	T10236	T10234	pobj	color,of
R6911	T10237	T10233	prep	in,distribution
R6912	T10238	T10239	det	the,limbs
R6913	T10239	T10237	pobj	limbs,in
R6914	T10240	T10228	punct	", ",affects
R6915	T10241	T10228	prep	with,affects
R6916	T10242	T10243	nsubj	areas,giving
R6917	T10243	T10241	pcomp	giving,with
R6918	T10244	T10245	dep	that,produce
R6919	T10245	T10242	relcl	produce,areas
R6920	T10246	T10245	aux	would,produce
R6921	T10247	T10245	advmod	normally,produce
R6922	T10248	T10249	amod	black,hair
R6923	T10249	T10245	dobj	hair,produce
R6924	T10250	T10243	dobj	rise,giving
R6925	T10251	T10243	prep	to,giving
R6926	T10252	T10253	amod	yellow,hair
R6927	T10253	T10251	pobj	hair,to
R6928	T10254	T10243	advmod	instead,giving
R6929	T10255	T10228	punct	.,affects
R6930	T10257	T10258	advmod	However,correspond
R6931	T10259	T10258	punct	", ",correspond
R6932	T10260	T10261	preconj	neither,patterns
R6933	T10261	T10258	nsubj	patterns,correspond
R6934	T10262	T10261	amod	normal,patterns
R6935	T10263	T10261	prep	of,patterns
R6936	T10264	T10265	amod	pigment,type
R6937	T10265	T10267	compound	type,synthesis
R6938	T10266	T10265	punct	-,type
R6939	T10267	T10263	pobj	synthesis,of
R6940	T10268	T10261	prep	in,patterns
R6941	T10269	T10270	det	the,limb
R6942	T10270	T10268	pobj	limb,in
R6943	T10271	T10261	cc	nor,patterns
R6944	T10272	T10273	poss	their,disruption
R6945	T10273	T10261	conj	disruption,patterns
R6946	T10274	T10273	prep	in,disruption
R6947	T10275	T10276	compound	deH,deH
R6948	T10276	T10278	compound	deH,mice
R6949	T10277	T10276	punct	/,deH
R6950	T10278	T10274	pobj	mice,in
R6951	T10279	T10258	prep	to,correspond
R6952	T10280	T10281	amod	obvious,compartments
R6953	T10281	T10279	pobj	compartments,to
R6954	T10282	T10281	amod	developmental,compartments
R6955	T10283	T10258	punct	.,correspond
R6956	T10285	T10286	advmod	Furthermore,have
R6957	T10287	T10286	punct	", ",have
R6958	T10288	T10286	nsubj	losses,have
R6959	T10289	T10288	prep	of,losses
R6960	T10290	T10289	pobj	function,of
R6961	T10291	T10288	prep	for,losses
R6962	T10292	T10291	pobj	En1,for
R6963	T10293	T10292	cc	or,En1
R6964	T10294	T10292	conj	Wnt7a,En1
R6965	T10295	T10288	punct	", ",losses
R6966	T10296	T10297	dep	which,cause
R6967	T10297	T10288	relcl	cause,losses
R6968	T10298	T10299	det	a,transformation
R6969	T10299	T10297	dobj	transformation,cause
R6970	T10300	T10299	amod	partial,transformation
R6971	T10301	T10299	prep	of,transformation
R6972	T10302	T10303	det	the,limb
R6973	T10303	T10301	pobj	limb,of
R6974	T10304	T10303	amod	distal,limb
R6975	T10305	T10299	prep	from,transformation
R6976	T10306	T10305	pobj	dorsum,from
R6977	T10307	T10305	prep	to,from
R6978	T10308	T10307	pobj	ventrum,to
R6979	T10309	T10310	punct	(,Loomis
R6980	T10310	T10305	meta	Loomis,from
R6981	T10311	T10310	nmod	et,Loomis
R6982	T10312	T10310	nmod	al.,Loomis
R6983	T10313	T10310	nummod	1996,Loomis
R6984	T10314	T10310	punct	),Loomis
R6985	T10315	T10305	cc	or,from
R6986	T10316	T10317	npadvmod	ventrum,to
R6987	T10317	T10305	conj	to,from
R6988	T10318	T10317	pobj	dorsum,to
R6989	T10319	T10320	punct	(,Parr
R6990	T10320	T10317	meta	Parr,to
R6991	T10321	T10320	cc	and,Parr
R6992	T10322	T10320	conj	McMahon,Parr
R6993	T10323	T10322	nummod	1995,McMahon
R6994	T10324	T10322	punct	),McMahon
R6995	T10325	T10297	punct	", ",cause
R6996	T10326	T10297	advmod	respectively,cause
R6997	T10327	T10286	punct	", ",have
R6998	T10328	T10329	det	no,effect
R6999	T10329	T10286	dobj	effect,have
R7000	T10330	T10329	prep	on,effect
R7001	T10331	T10332	amod	regional,patterns
R7002	T10332	T10330	pobj	patterns,on
R7003	T10333	T10332	prep	of,patterns
R7004	T10334	T10335	compound	Agouti,expression
R7005	T10335	T10333	pobj	expression,of
R7006	T10336	T10332	cc	or,patterns
R7007	T10337	T10332	conj	distribution,patterns
R7008	T10338	T10337	prep	of,distribution
R7009	T10339	T10340	compound	hair,color
R7010	T10340	T10342	compound	color,regions
R7011	T10341	T10340	punct	-,color
R7012	T10342	T10338	pobj	regions,of
R7013	T10343	T10344	punct	(,Y.
R7014	T10344	T10286	meta	Y.,have
R7015	T10345	T10344	nmod	Chen,Y.
R7016	T10346	T10344	punct	", ",Y.
R7017	T10347	T10344	amod	unpublished,Y.
R7018	T10348	T10344	nmod	data,Y.
R7019	T10349	T10344	punct	),Y.
R7020	T10350	T10286	punct	.,have
R7021	T10352	T10353	punct	(,is
R7022	T10354	T10355	amod	Ectopic,pigmentation
R7023	T10355	T10353	nsubj	pigmentation,is
R7024	T10356	T10355	prep	of,pigmentation
R7025	T10357	T10358	det	the,footpads
R7026	T10358	T10356	pobj	footpads,of
R7027	T10359	T10358	amod	ventral,footpads
R7028	T10360	T10361	dep	that,develops
R7029	T10361	T10355	relcl	develops,pigmentation
R7030	T10362	T10361	prep	in,develops
R7031	T10363	T10364	compound	En1,mice
R7032	T10364	T10362	pobj	mice,in
R7033	T10365	T10364	compound	mutant,mice
R7034	T10366	T10353	acomp	unrelated,is
R7035	T10367	T10366	prep	to,unrelated
R7036	T10368	T10369	compound	pigment,type
R7037	T10369	T10371	compound	type,synthesis
R7038	T10370	T10369	punct	-,type
R7039	T10371	T10367	pobj	synthesis,to
R7040	T10372	T10353	cc	and,is
R7041	T10373	T10374	advmod	instead,reflects
R7042	T10374	T10353	conj	reflects,is
R7043	T10375	T10374	advmod	likely,reflects
R7044	T10376	T10377	det	a,requirement
R7045	T10377	T10374	dobj	requirement,reflects
R7046	T10378	T10377	prep	for,requirement
R7047	T10379	T10378	pobj	En1,for
R7048	T10380	T10377	punct	", ",requirement
R7049	T10381	T10377	amod	independent,requirement
R7050	T10382	T10381	prep	of,independent
R7051	T10383	T10382	pobj	Wnt7a,of
R7052	T10384	T10377	punct	", ",requirement
R7053	T10385	T10386	aux	to,repress
R7054	T10386	T10377	acl	repress,requirement
R7055	T10387	T10386	dobj	migration,repress
R7056	T10388	T10387	cc	or,migration
R7057	T10389	T10387	conj	proliferation,migration
R7058	T10390	T10387	punct	(,migration
R7059	T10391	T10387	cc	or,migration
R7060	T10392	T10387	conj	both,migration
R7061	T10393	T10392	punct	),both
R7062	T10394	T10387	prep	of,migration
R7063	T10395	T10396	compound	pigment,cells
R7064	T10396	T10394	pobj	cells,of
R7065	T10397	T10387	prep	in,migration
R7066	T10398	T10399	amod	ventral,epidermis
R7067	T10399	T10397	pobj	epidermis,in
R7068	T10400	T10401	punct	[,Cygan
R7069	T10401	T10374	meta	Cygan,reflects
R7070	T10402	T10401	nmod	et,Cygan
R7071	T10403	T10401	nmod	al.,Cygan
R7072	T10404	T10401	nummod	1997,Cygan
R7073	T10405	T10401	punct	;,Cygan
R7074	T10406	T10401	nmod	Loomis,Cygan
R7075	T10407	T10401	nmod	et,Cygan
R7076	T10408	T10401	nmod	al.,Cygan
R7077	T10409	T10401	nummod	1998,Cygan
R7078	T10410	T10401	punct	],Cygan
R7079	T10411	T10353	punct	.,is
R7080	T10412	T10353	punct	),is
R7081	T10414	T10415	det	These,considerations
R7082	T10415	T10416	nsubj	considerations,notwithstanding
R7083	T10416	T10417	advcl	notwithstanding,shares
R7084	T10418	T10417	punct	", ",shares
R7085	T10419	T10417	nsubj	control,shares
R7086	T10420	T10419	prep	of,control
R7087	T10421	T10422	amod	dorsoventral,pattern
R7088	T10422	T10420	pobj	pattern,of
R7089	T10423	T10422	compound	trunk,pattern
R7090	T10424	T10419	prep	by,control
R7091	T10425	T10424	pobj	Tbx15,by
R7092	T10426	T10427	amod	certain,features
R7093	T10427	T10417	dobj	features,shares
R7094	T10428	T10417	prep	with,shares
R7095	T10429	T10428	pobj	control,with
R7096	T10430	T10429	prep	of,control
R7097	T10431	T10432	amod	dorsoventral,patterning
R7098	T10432	T10430	pobj	patterning,of
R7099	T10433	T10432	compound	limb,patterning
R7100	T10434	T10429	prep	by,control
R7101	T10435	T10434	pobj	Lmx1b,by
R7102	T10436	T10435	punct	", ",Lmx1b
R7103	T10437	T10438	det	a,factor
R7104	T10438	T10435	appos	factor,Lmx1b
R7105	T10439	T10440	compound	LIM,domain
R7106	T10440	T10438	compound	domain,factor
R7107	T10441	T10438	compound	transcription,factor
R7108	T10442	T10443	dep	that,acts
R7109	T10443	T10438	relcl	acts,factor
R7110	T10444	T10443	advmod	downstream,acts
R7111	T10445	T10444	prep	of,downstream
R7112	T10446	T10445	pobj	Wnt7a,of
R7113	T10447	T10446	cc	and,Wnt7a
R7114	T10448	T10446	conj	En1,Wnt7a
R7115	T10449	T10450	punct	(,Riddle
R7116	T10450	T10429	meta	Riddle,control
R7117	T10451	T10450	nmod	et,Riddle
R7118	T10452	T10450	nmod	al.,Riddle
R7119	T10453	T10450	nummod	1995,Riddle
R7120	T10454	T10450	punct	;,Riddle
R7121	T10455	T10450	conj	Vogel,Riddle
R7122	T10456	T10455	nmod	et,Vogel
R7123	T10457	T10455	nmod	al.,Vogel
R7124	T10458	T10455	nummod	1995,Vogel
R7125	T10459	T10455	punct	;,Vogel
R7126	T10460	T10455	conj	Cygan,Vogel
R7127	T10461	T10460	nmod	et,Cygan
R7128	T10462	T10460	nmod	al.,Cygan
R7129	T10463	T10460	nummod	1997,Cygan
R7130	T10464	T10460	punct	;,Cygan
R7131	T10465	T10460	conj	Logan,Cygan
R7132	T10466	T10465	nmod	et,Logan
R7133	T10467	T10465	nmod	al.,Logan
R7134	T10468	T10465	nummod	1997,Logan
R7135	T10469	T10465	punct	;,Logan
R7136	T10470	T10465	conj	Loomis,Logan
R7137	T10471	T10470	nmod	et,Loomis
R7138	T10472	T10470	nmod	al.,Loomis
R7139	T10473	T10470	nummod	1998,Loomis
R7140	T10474	T10470	punct	;,Loomis
R7141	T10475	T10470	conj	Chen,Loomis
R7142	T10476	T10475	cc	and,Chen
R7143	T10477	T10475	conj	Johnson,Chen
R7144	T10478	T10477	nummod	2002,Johnson
R7145	T10479	T10477	punct	),Johnson
R7146	T10480	T10417	punct	.,shares
R7147	T10482	T10483	preconj	Both,Tbx15
R7148	T10483	T10484	nsubj	Tbx15,act
R7149	T10485	T10483	cc	and,Tbx15
R7150	T10486	T10483	conj	Lmx1b,Tbx15
R7151	T10487	T10484	advmod	autonomously,act
R7152	T10488	T10484	prep	in,act
R7153	T10489	T10490	amod	mesenchymal,cells
R7154	T10490	T10488	pobj	cells,in
R7155	T10491	T10492	aux	to,promote
R7156	T10492	T10484	advcl	promote,act
R7157	T10493	T10494	det	a,identity
R7158	T10494	T10492	dobj	identity,promote
R7159	T10495	T10494	amod	dorsal,identity
R7160	T10496	T10484	punct	", ",act
R7161	T10497	T10484	cc	yet,act
R7162	T10498	T10484	conj	have,act
R7163	T10499	T10500	compound	expression,domains
R7164	T10500	T10498	dobj	domains,have
R7165	T10501	T10502	dep	that,correspond
R7166	T10502	T10500	relcl	correspond,domains
R7167	T10503	T10502	aux	do,correspond
R7168	T10504	T10502	neg	not,correspond
R7169	T10505	T10502	prep	to,correspond
R7170	T10506	T10507	compound	cell,lineage
R7171	T10507	T10508	compound	lineage,compartments
R7172	T10508	T10505	pobj	compartments,to
R7173	T10509	T10502	prep	in,correspond
R7174	T10510	T10511	det	the,flank
R7175	T10511	T10509	pobj	flank,in
R7176	T10512	T10513	punct	(,Tbx15
R7177	T10513	T10511	parataxis	Tbx15,flank
R7178	T10514	T10513	punct	),Tbx15
R7179	T10515	T10511	cc	or,flank
R7180	T10516	T10517	det	the,limb
R7181	T10517	T10511	conj	limb,flank
R7182	T10518	T10519	punct	(,Lmx1b
R7183	T10519	T10517	parataxis	Lmx1b,limb
R7184	T10520	T10519	punct	),Lmx1b
R7185	T10521	T10522	punct	(,Altabef
R7186	T10522	T10498	meta	Altabef,have
R7187	T10523	T10522	nmod	et,Altabef
R7188	T10524	T10522	nmod	al.,Altabef
R7189	T10525	T10522	nummod	1997,Altabef
R7190	T10526	T10522	punct	;,Altabef
R7191	T10527	T10522	nmod	Michaud,Altabef
R7192	T10528	T10522	nmod	et,Altabef
R7193	T10529	T10522	nmod	al.,Altabef
R7194	T10530	T10522	nummod	1997,Altabef
R7195	T10531	T10522	punct	),Altabef
R7196	T10532	T10484	punct	.,act
R7197	T10534	T10535	prep	In,depends
R7198	T10536	T10537	det	the,case
R7199	T10537	T10534	pobj	case,In
R7200	T10538	T10537	prep	of,case
R7201	T10539	T10538	pobj	Lmx1b,of
R7202	T10540	T10535	punct	", ",depends
R7203	T10541	T10542	poss	its,expression
R7204	T10542	T10535	nsubj	expression,depends
R7205	T10543	T10542	prep	in,expression
R7206	T10544	T10545	det	the,limb
R7207	T10545	T10543	pobj	limb,in
R7208	T10546	T10545	amod	distal,limb
R7209	T10547	T10535	prep	on,depends
R7210	T10548	T10547	pobj	Wnt7a,on
R7211	T10549	T10548	acl	produced,Wnt7a
R7212	T10550	T10549	prep	in,produced
R7213	T10551	T10552	det	the,ectoderm
R7214	T10552	T10550	pobj	ectoderm,in
R7215	T10553	T10552	amod	overlying,ectoderm
R7216	T10554	T10552	amod	dorsal,ectoderm
R7217	T10555	T10556	punct	(,Riddle
R7218	T10556	T10535	meta	Riddle,depends
R7219	T10557	T10556	nmod	et,Riddle
R7220	T10558	T10556	nmod	al.,Riddle
R7221	T10559	T10556	nummod	1995,Riddle
R7222	T10560	T10556	punct	;,Riddle
R7223	T10561	T10556	nmod	Cygan,Riddle
R7224	T10562	T10556	nmod	et,Riddle
R7225	T10563	T10556	nmod	al.,Riddle
R7226	T10564	T10556	nummod	1997,Riddle
R7227	T10565	T10556	punct	;,Riddle
R7228	T10566	T10556	nmod	Loomis,Riddle
R7229	T10567	T10556	nmod	et,Riddle
R7230	T10568	T10556	nmod	al.,Riddle
R7231	T10569	T10556	nummod	1998,Riddle
R7232	T10570	T10556	punct	),Riddle
R7233	T10571	T10535	punct	.,depends
R7234	T10573	T10574	nsubjpass	Wnt7a,restricted
R7235	T10575	T10574	punct	", ",restricted
R7236	T10576	T10574	prep	in,restricted
R7237	T10577	T10576	pobj	turn,in
R7238	T10578	T10574	punct	", ",restricted
R7239	T10579	T10574	auxpass	is,restricted
R7240	T10580	T10574	prep	to,restricted
R7241	T10581	T10582	amod	dorsal,ectoderm
R7242	T10582	T10580	pobj	ectoderm,to
R7243	T10583	T10574	agent	by,restricted
R7244	T10584	T10583	pobj	En1,by
R7245	T10585	T10574	prep	in,restricted
R7246	T10586	T10587	det	the,ectoderm
R7247	T10587	T10585	pobj	ectoderm,in
R7248	T10588	T10587	amod	ventral,ectoderm
R7249	T10589	T10590	punct	(,Loomis
R7250	T10590	T10574	meta	Loomis,restricted
R7251	T10591	T10590	nmod	et,Loomis
R7252	T10592	T10590	nmod	al.,Loomis
R7253	T10593	T10590	nummod	1996,Loomis
R7254	T10594	T10590	punct	;,Loomis
R7255	T10595	T10590	nmod	Cygan,Loomis
R7256	T10596	T10590	nmod	et,Loomis
R7257	T10597	T10590	nmod	al.,Loomis
R7258	T10598	T10590	nummod	1997,Loomis
R7259	T10599	T10590	punct	;,Loomis
R7260	T10600	T10590	nmod	Logan,Loomis
R7261	T10601	T10590	nmod	et,Loomis
R7262	T10602	T10590	nmod	al.,Loomis
R7263	T10603	T10590	nummod	1997,Loomis
R7264	T10604	T10590	punct	),Loomis
R7265	T10605	T10574	punct	", ",restricted
R7266	T10606	T10607	poss	whose,expression
R7267	T10607	T10608	dep	expression,marks
R7268	T10608	T10574	ccomp	marks,restricted
R7269	T10609	T10610	det	a,boundary
R7270	T10610	T10608	dobj	boundary,marks
R7271	T10611	T10610	compound	lineage,boundary
R7272	T10612	T10610	amod	coincident,boundary
R7273	T10613	T10612	prep	with,coincident
R7274	T10614	T10615	det	the,midline
R7275	T10615	T10613	pobj	midline,with
R7276	T10616	T10615	amod	dorsoventral,midline
R7277	T10617	T10615	prep	of,midline
R7278	T10618	T10619	det	the,ridge
R7279	T10619	T10617	pobj	ridge,of
R7280	T10620	T10619	amod	apical,ridge
R7281	T10621	T10619	amod	ectodermal,ridge
R7282	T10622	T10623	punct	(,Michaud
R7283	T10623	T10608	meta	Michaud,marks
R7284	T10624	T10623	nmod	Altabef,Michaud
R7285	T10625	T10623	nmod	et,Michaud
R7286	T10626	T10623	nmod	al.,Michaud
R7287	T10627	T10623	nummod	1997,Michaud
R7288	T10628	T10623	punct	;,Michaud
R7289	T10629	T10623	nmod	et,Michaud
R7290	T10630	T10623	nmod	al.,Michaud
R7291	T10631	T10623	nummod	1997,Michaud
R7292	T10632	T10623	punct	;,Michaud
R7293	T10633	T10623	nmod	Kimmel,Michaud
R7294	T10634	T10623	nmod	et,Michaud
R7295	T10635	T10623	nmod	al.,Michaud
R7296	T10636	T10623	nummod	2000,Michaud
R7297	T10637	T10623	punct	),Michaud
R7298	T10638	T10574	punct	.,restricted
R7299	T10640	T10641	mark	As,described
R7300	T10641	T10642	advcl	described,reported
R7301	T10643	T10641	advmod	above,described
R7302	T10644	T10642	punct	", ",reported
R7303	T10645	T10646	nmod	En1,mutations
R7304	T10646	T10642	nsubjpass	mutations,reported
R7305	T10647	T10645	cc	or,En1
R7306	T10648	T10645	conj	Wnt7a,En1
R7307	T10649	T10642	aux	have,reported
R7308	T10650	T10642	neg	not,reported
R7309	T10651	T10642	auxpass	been,reported
R7310	T10652	T10653	aux	to,affect
R7311	T10653	T10642	xcomp	affect,reported
R7312	T10654	T10653	dobj	patterns,affect
R7313	T10655	T10654	prep	of,patterns
R7314	T10656	T10657	compound	hair,color
R7315	T10657	T10659	compound	color,distribution
R7316	T10658	T10657	punct	-,color
R7317	T10659	T10655	pobj	distribution,of
R7318	T10660	T10661	punct	(,C.
R7319	T10661	T10642	meta	C.,reported
R7320	T10662	T10661	nmod	Loomis,C.
R7321	T10663	T10661	punct	", ",C.
R7322	T10664	T10665	amod	personal,communication
R7323	T10665	T10661	conj	communication,C.
R7324	T10666	T10665	punct	;,communication
R7325	T10667	T10665	conj	Parr,communication
R7326	T10668	T10667	cc	and,Parr
R7327	T10669	T10667	conj	McMahon,Parr
R7328	T10670	T10669	nummod	1995,McMahon
R7329	T10671	T10669	punct	;,McMahon
R7330	T10672	T10669	conj	Loomis,McMahon
R7331	T10673	T10672	nmod	et,Loomis
R7332	T10674	T10672	advmod	al.,Loomis
R7333	T10675	T10672	nummod	1996,Loomis
R7334	T10676	T10672	punct	),Loomis
R7335	T10677	T10642	punct	.,reported
R7336	T10679	T10680	advmod	However,apply
R7337	T10681	T10680	punct	", ",apply
R7338	T10682	T10683	det	the,theme
R7339	T10683	T10680	nsubj	theme,apply
R7340	T10684	T10683	amod	essential,theme
R7341	T10685	T10686	mark	that,control
R7342	T10686	T10683	acl	control,theme
R7343	T10687	T10688	amod	ectodermal,compartments
R7344	T10688	T10686	nsubj	compartments,control
R7345	T10689	T10688	compound	lineage,compartments
R7346	T10690	T10691	det	the,fate
R7347	T10691	T10686	dobj	fate,control
R7348	T10692	T10691	prep	of,fate
R7349	T10693	T10694	amod	underlying,mesenchyme
R7350	T10694	T10692	pobj	mesenchyme,of
R7351	T10695	T10686	prep	in,control
R7352	T10696	T10697	amod	developing,limbs
R7353	T10697	T10695	pobj	limbs,in
R7354	T10698	T10680	aux	may,apply
R7355	T10699	T10680	prep	to,apply
R7356	T10700	T10701	det	the,trunk
R7357	T10701	T10699	pobj	trunk,to
R7358	T10702	T10703	advmod	as,as
R7359	T10703	T10701	cc	as,trunk
R7360	T10704	T10703	advmod	well,as
R7361	T10705	T10706	det	the,limb
R7362	T10706	T10701	conj	limb,trunk
R7363	T10707	T10680	punct	.,apply
R7364	T10709	T10710	det	The,glands
R7365	T10710	T10712	nsubj	glands,develop
R7366	T10711	T10710	amod	mammary,glands
R7367	T10713	T10712	advmod	also,develop
R7368	T10714	T10712	prep	at,develop
R7369	T10715	T10716	det	a,position
R7370	T10716	T10714	pobj	position,at
R7371	T10717	T10716	amod	stereotyped,position
R7372	T10718	T10716	amod	dorsoventral,position
R7373	T10719	T10712	cc	and,develop
R7374	T10720	T10712	conj	depend,develop
R7375	T10721	T10720	prep	on,depend
R7376	T10722	T10723	amod	epithelial,mesenchymal
R7377	T10723	T10725	amod	mesenchymal,interactions
R7378	T10724	T10723	punct	–,mesenchymal
R7379	T10725	T10721	pobj	interactions,on
R7380	T10726	T10712	punct	.,develop
R7381	T10728	T10729	advmod	However,are
R7382	T10730	T10729	punct	", ",are
R7383	T10731	T10732	det	the,number
R7384	T10732	T10729	nsubj	number,are
R7385	T10733	T10732	cc	and,number
R7386	T10734	T10735	amod	apparent,position
R7387	T10735	T10732	conj	position,number
R7388	T10736	T10732	prep	of,number
R7389	T10737	T10738	det	the,glands
R7390	T10738	T10736	pobj	glands,of
R7391	T10739	T10738	amod	mammary,glands
R7392	T10740	T10729	acomp	normal,are
R7393	T10741	T10729	prep	in,are
R7394	T10742	T10743	compound	deH,deH
R7395	T10743	T10745	compound	deH,animals
R7396	T10744	T10743	punct	/,deH
R7397	T10745	T10741	pobj	animals,in
R7398	T10746	T10729	punct	", ",are
R7399	T10747	T10729	advcl	indicating,are
R7400	T10748	T10749	det	the,existence
R7401	T10749	T10747	dobj	existence,indicating
R7402	T10750	T10749	prep	of,existence
R7403	T10751	T10752	amod	additional,mechanisms
R7404	T10752	T10750	pobj	mechanisms,of
R7405	T10753	T10754	dep	that,control
R7406	T10754	T10752	relcl	control,mechanisms
R7407	T10755	T10756	amod	dorsoventral,patterning
R7408	T10756	T10754	dobj	patterning,control
R7409	T10757	T10754	prep	in,control
R7410	T10758	T10759	det	the,trunk
R7411	T10759	T10757	pobj	trunk,in
R7412	T10760	T10761	advmod	as,as
R7413	T10761	T10757	cc	as,in
R7414	T10762	T10761	advmod	well,as
R7415	T10763	T10757	conj	in,in
R7416	T10764	T10765	det	the,limbs
R7417	T10765	T10763	pobj	limbs,in
R7418	T10766	T10729	punct	.,are
R7419	T10768	T10769	det	These,ideas
R7420	T10769	T10770	nsubjpass	ideas,summarized
R7421	T10771	T10770	auxpass	are,summarized
R7422	T10772	T10770	prep	in,summarized
R7423	T10773	T10774	det	the,model
R7424	T10774	T10772	pobj	model,in
R7425	T10775	T10774	acl	shown,model
R7426	T10776	T10775	prep	in,shown
R7427	T10777	T10776	pobj	Figure,in
R7428	T10778	T10777	nummod	9B,Figure
R7429	T10779	T10770	punct	.,summarized
R7430	T10781	T10782	nsubj	We,speculate
R7431	T10783	T10784	mark	that,promotes
R7432	T10784	T10782	ccomp	promotes,speculate
R7433	T10785	T10786	det	a,signal
R7434	T10786	T10784	nsubj	signal,promotes
R7435	T10787	T10786	amod	diffusible,signal
R7436	T10788	T10786	prep	from,signal
R7437	T10789	T10790	amod	dorsal,ectoderm
R7438	T10790	T10788	pobj	ectoderm,from
R7439	T10791	T10790	compound	trunk,ectoderm
R7440	T10792	T10784	punct	", ",promotes
R7441	T10793	T10784	prep	at,promotes
R7442	T10794	T10793	cc	or,at
R7443	T10795	T10796	advmod	prior,E11.5
R7444	T10796	T10793	conj	E11.5,at
R7445	T10797	T10795	prep	to,prior
R7446	T10798	T10784	punct	", ",promotes
R7447	T10799	T10784	dobj	expression,promotes
R7448	T10800	T10799	prep	of,expression
R7449	T10801	T10800	pobj	Tbx15,of
R7450	T10802	T10799	prep	in,expression
R7451	T10803	T10804	amod	dorsal,mesenchyme
R7452	T10804	T10802	pobj	mesenchyme,in
R7453	T10805	T10804	compound	trunk,mesenchyme
R7454	T10806	T10799	punct	", ",expression
R7455	T10807	T10808	dep	which,establishes
R7456	T10808	T10799	relcl	establishes,expression
R7457	T10809	T10808	advmod	then,establishes
R7458	T10810	T10811	amod	dorsal,identity
R7459	T10811	T10808	dobj	identity,establishes
R7460	T10812	T10811	amod	positional,identity
R7461	T10813	T10811	prep	of,identity
R7462	T10814	T10815	det	those,cells
R7463	T10815	T10813	pobj	cells,of
R7464	T10816	T10817	mark	as,manifested
R7465	T10817	T10808	advcl	manifested,establishes
R7466	T10818	T10817	agent	by,manifested
R7467	T10819	T10818	pobj	differences,by
R7468	T10820	T10819	prep	in,differences
R7469	T10821	T10822	compound	Agouti,expression
R7470	T10822	T10820	pobj	expression,in
R7471	T10823	T10822	punct	", ",expression
R7472	T10824	T10825	compound	pigment,cell
R7473	T10825	T10827	compound	cell,development
R7474	T10826	T10825	punct	-,cell
R7475	T10827	T10822	conj	development,expression
R7476	T10828	T10827	punct	", ",development
R7477	T10829	T10827	cc	and,development
R7478	T10830	T10831	compound	hair,growth
R7479	T10831	T10827	conj	growth,development
R7480	T10832	T10782	punct	.,speculate
R7481	T10834	T10835	mark	Because,corresponds
R7482	T10835	T10842	advcl	corresponds,depict
R7483	T10836	T10837	det	the,limit
R7484	T10837	T10835	nsubj	limit,corresponds
R7485	T10838	T10837	amod	ventral,limit
R7486	T10839	T10837	prep	of,limit
R7487	T10840	T10841	compound	Tbx15,expression
R7488	T10841	T10839	pobj	expression,of
R7489	T10843	T10835	prep	to,corresponds
R7490	T10844	T10845	det	the,limit
R7491	T10845	T10843	pobj	limit,to
R7492	T10846	T10845	amod	dorsal,limit
R7493	T10847	T10845	prep	of,limit
R7494	T10848	T10849	compound	En1,expression
R7495	T10849	T10847	pobj	expression,of
R7496	T10850	T10835	cc	and,corresponds
R7497	T10851	T10852	mark	because,lies
R7498	T10852	T10835	conj	lies,corresponds
R7499	T10853	T10854	det	the,position
R7500	T10854	T10852	nsubj	position,lies
R7501	T10855	T10854	amod	normal,position
R7502	T10856	T10854	prep	of,position
R7503	T10857	T10858	det	the,boundary
R7504	T10858	T10856	pobj	boundary,of
R7505	T10859	T10858	compound	pigmentation,boundary
R7506	T10860	T10861	advmod	approximately,in
R7507	T10861	T10852	prep	in,lies
R7508	T10862	T10861	pobj	register,in
R7509	T10863	T10862	prep	with,register
R7510	T10864	T10865	det	the,outgrowths
R7511	T10865	T10863	pobj	outgrowths,with
R7512	T10866	T10867	compound	limb,bud
R7513	T10867	T10865	compound	bud,outgrowths
R7514	T10868	T10867	punct	-,bud
R7515	T10869	T10842	punct	", ",depict
R7516	T10870	T10842	nsubj	we,depict
R7517	T10871	T10872	det	the,position
R7518	T10872	T10842	dobj	position,depict
R7519	T10873	T10872	prep	of,position
R7520	T10874	T10875	det	a,boundary
R7521	T10875	T10873	pobj	boundary,of
R7522	T10876	T10875	amod	putative,boundary
R7523	T10877	T10875	amod	dorsoventral,boundary
R7524	T10878	T10842	prep	in,depict
R7525	T10879	T10880	compound	trunk,ectoderm
R7526	T10880	T10878	pobj	ectoderm,in
R7527	T10881	T10842	prep	as,depict
R7528	T10882	T10881	amod	coincident,as
R7529	T10883	T10882	prep	with,coincident
R7530	T10884	T10885	det	the,boundary
R7531	T10885	T10883	pobj	boundary,with
R7532	T10886	T10885	nmod	limb,boundary
R7533	T10887	T10885	amod	dorsoventral,boundary
R7534	T10888	T10842	punct	.,depict
R7535	T10890	T10891	det	This,model
R7536	T10891	T10892	nsubj	model,is
R7537	T10893	T10892	acomp	consistent,is
R7538	T10894	T10893	prep	with,consistent
R7539	T10895	T10894	pobj	studies,with
R7540	T10896	T10895	prep	in,studies
R7541	T10897	T10898	det	the,chick
R7542	T10898	T10896	pobj	chick,in
R7543	T10899	T10898	punct	", ",chick
R7544	T10900	T10901	advmod	where,exist
R7545	T10901	T10898	relcl	exist,chick
R7546	T10902	T10903	amod	distinct,compartments
R7547	T10903	T10901	nsubj	compartments,exist
R7548	T10904	T10903	amod	dorsal,compartments
R7549	T10905	T10904	cc	and,dorsal
R7550	T10906	T10904	conj	ventral,dorsal
R7551	T10907	T10903	compound	lineage,compartments
R7552	T10908	T10901	prep	for,exist
R7553	T10909	T10908	pobj	ectoderm,for
R7554	T10910	T10901	prep	in,exist
R7555	T10911	T10912	preconj	both,limb
R7556	T10912	T10910	pobj	limb,in
R7557	T10913	T10912	det	the,limb
R7558	T10914	T10915	punct	(,Michaud
R7559	T10915	T10912	meta	Michaud,limb
R7560	T10916	T10915	nmod	Altabef,Michaud
R7561	T10917	T10915	nmod	et,Michaud
R7562	T10918	T10915	nmod	al.,Michaud
R7563	T10919	T10915	nummod	1997,Michaud
R7564	T10920	T10915	punct	", ",Michaud
R7565	T10921	T10915	nummod	2000,Michaud
R7566	T10922	T10915	punct	;,Michaud
R7567	T10923	T10915	nmod	et,Michaud
R7568	T10924	T10915	nmod	al.,Michaud
R7569	T10925	T10915	nummod	1997,Michaud
R7570	T10926	T10915	punct	;,Michaud
R7571	T10927	T10915	nmod	Kimmel,Michaud
R7572	T10928	T10915	nmod	et,Michaud
R7573	T10929	T10915	nmod	al.,Michaud
R7574	T10930	T10915	nummod	2000,Michaud
R7575	T10931	T10915	punct	),Michaud
R7576	T10932	T10912	cc	and,limb
R7577	T10933	T10934	amod	interlimb,regions
R7578	T10934	T10912	conj	regions,limb
R7579	T10935	T10936	punct	(,Altabef
R7580	T10936	T10934	meta	Altabef,regions
R7581	T10937	T10936	nmod	et,Altabef
R7582	T10938	T10936	nmod	al.,Altabef
R7583	T10939	T10936	nummod	1997,Altabef
R7584	T10940	T10936	punct	", ",Altabef
R7585	T10941	T10936	nummod	2000,Altabef
R7586	T10942	T10936	punct	),Altabef
R7587	T10943	T10901	punct	", ",exist
R7588	T10944	T10945	cc	but,for
R7589	T10945	T10901	prep	for,exist
R7590	T10946	T10945	neg	not,for
R7591	T10947	T10948	compound	limb,mesoderm
R7592	T10948	T10945	pobj	mesoderm,for
R7593	T10949	T10950	punct	(,Altabef
R7594	T10950	T10948	meta	Altabef,mesoderm
R7595	T10951	T10950	nmod	et,Altabef
R7596	T10952	T10950	nmod	al.,Altabef
R7597	T10953	T10950	nummod	1997,Altabef
R7598	T10954	T10950	punct	;,Altabef
R7599	T10955	T10950	nmod	Michaud,Altabef
R7600	T10956	T10950	nmod	et,Altabef
R7601	T10957	T10950	nmod	al.,Altabef
R7602	T10958	T10950	nummod	1997,Altabef
R7603	T10959	T10950	punct	),Altabef
R7604	T10960	T10892	punct	.,is
R7605	T10962	T10963	prep	In,act
R7606	T10964	T10962	pobj	fact,In
R7607	T10965	T10963	punct	", ",act
R7608	T10966	T10967	det	the,mechanism
R7609	T10967	T10963	nsubj	mechanism,act
R7610	T10968	T10967	amod	same,mechanism
R7611	T10969	T10970	dep	that,determines
R7612	T10970	T10967	relcl	determines,mechanism
R7613	T10971	T10972	amod	dorsoventral,position
R7614	T10972	T10970	dobj	position,determines
R7615	T10973	T10972	prep	of,position
R7616	T10974	T10975	det	the,limbs
R7617	T10975	T10973	pobj	limbs,of
R7618	T10976	T10975	cc	and,limbs
R7619	T10977	T10978	det	the,ridge
R7620	T10978	T10975	conj	ridge,limbs
R7621	T10979	T10978	amod	apical,ridge
R7622	T10980	T10978	amod	ectodermal,ridge
R7623	T10981	T10963	aux	may,act
R7624	T10982	T10963	advmod	also,act
R7625	T10983	T10963	prep	on,act
R7626	T10984	T10983	pobj	expression,on
R7627	T10985	T10984	prep	of,expression
R7628	T10986	T10985	pobj	Tbx15,of
R7629	T10987	T10963	prep	in,act
R7630	T10988	T10989	det	the,trunk
R7631	T10989	T10987	pobj	trunk,in
R7632	T10990	T10963	punct	", ",act
R7633	T10991	T10992	mark	since,develop
R7634	T10992	T10963	advcl	develop,act
R7635	T10993	T10994	amod	ectopic,limbs
R7636	T10994	T10992	nsubj	limbs,develop
R7637	T10995	T10994	acl	induced,limbs
R7638	T10996	T10995	prep	in,induced
R7639	T10997	T10998	det	the,region
R7640	T10998	T10996	pobj	region,in
R7641	T10999	T10998	amod	interlimb,region
R7642	T11000	T10995	prep	by,induced
R7643	T11001	T11000	pobj	application,by
R7644	T11002	T11001	prep	of,application
R7645	T11003	T11004	compound	FGF,beads
R7646	T11004	T11002	pobj	beads,of
R7647	T11005	T10992	prep	along,develop
R7648	T11006	T11007	det	a,line
R7649	T11007	T11005	pobj	line,along
R7650	T11008	T11007	amod	single,line
R7651	T11009	T11010	dep	that,is
R7652	T11010	T11007	relcl	is,line
R7653	T11011	T11010	acomp	coincident,is
R7654	T11012	T11011	prep	with,coincident
R7655	T11013	T11014	amod	normal,buds
R7656	T11014	T11012	pobj	buds,with
R7657	T11015	T11014	compound	limb,buds
R7658	T11016	T11014	punct	(,buds
R7659	T11017	T11014	cc	and,buds
R7660	T11018	T11019	det	the,boundary
R7661	T11019	T11014	conj	boundary,buds
R7662	T11020	T11019	amod	future,boundary
R7663	T11021	T11019	compound	pigmentation,boundary
R7664	T11022	T10992	punct	),develop
R7665	T11023	T11024	punct	(,Cohn
R7666	T11024	T10992	meta	Cohn,develop
R7667	T11025	T11024	nmod	et,Cohn
R7668	T11026	T11024	nmod	al.,Cohn
R7669	T11027	T11024	nummod	1995,Cohn
R7670	T11028	T11024	punct	;,Cohn
R7671	T11029	T11024	nmod	Crossley,Cohn
R7672	T11030	T11024	nmod	et,Cohn
R7673	T11031	T11024	nmod	al.,Cohn
R7674	T11032	T11024	nummod	1996,Cohn
R7675	T11033	T11024	punct	;,Cohn
R7676	T11034	T11024	nmod	Vogel,Cohn
R7677	T11035	T11024	nmod	et,Cohn
R7678	T11036	T11024	nmod	al.,Cohn
R7679	T11037	T11024	nummod	1996,Cohn
R7680	T11038	T11024	punct	;,Cohn
R7681	T11039	T11024	nmod	Altabef,Cohn
R7682	T11040	T11024	nmod	et,Cohn
R7683	T11041	T11024	nmod	al.,Cohn
R7684	T11042	T11024	nummod	1997,Cohn
R7685	T11043	T11024	punct	", ",Cohn
R7686	T11044	T11024	nummod	2000,Cohn
R7687	T11045	T11024	punct	),Cohn
R7688	T11046	T10963	punct	.,act
R7689	T11048	T11049	poss	Our,model
R7690	T11049	T11050	nsubj	model,predicts
R7691	T11051	T11052	mark	that,give
R7692	T11052	T11050	ccomp	give,predicts
R7693	T11053	T11054	amod	ectopic,expression
R7694	T11054	T11052	nsubj	expression,give
R7695	T11055	T11054	prep	of,expression
R7696	T11056	T11055	pobj	Tbx15,of
R7697	T11057	T11054	prep	in,expression
R7698	T11058	T11059	amod	ventral,mesenchyme
R7699	T11059	T11057	pobj	mesenchyme,in
R7700	T11060	T11052	aux	should,give
R7701	T11061	T11052	dobj	rise,give
R7702	T11062	T11052	prep	to,give
R7703	T11063	T11064	det	a,phenotype
R7704	T11064	T11062	pobj	phenotype,to
R7705	T11065	T11064	amod	dorsalized,phenotype
R7706	T11066	T11064	compound	pigmentation,phenotype
R7707	T11067	T11052	cc	and,give
R7708	T11068	T11069	aux	could,tested
R7709	T11069	T11052	conj	tested,give
R7710	T11070	T11069	auxpass	be,tested
R7711	T11071	T11069	prep	with,tested
R7712	T11072	T11073	nmod	gain,approaches
R7713	T11073	T11071	pobj	approaches,with
R7714	T11074	T11072	punct	-,gain
R7715	T11075	T11072	prep	of,gain
R7716	T11076	T11075	punct	-,of
R7717	T11077	T11075	pobj	function,of
R7718	T11078	T11050	punct	.,predicts
R7719	T11080	T11081	advmod	However,is
R7720	T11082	T11081	punct	", ",is
R7721	T11083	T11084	compound	Tbx15,expression
R7722	T11084	T11081	nsubj	expression,is
R7723	T11085	T11086	advmod	very,dynamic
R7724	T11086	T11081	acomp	dynamic,is
R7725	T11087	T11081	cc	and,is
R7726	T11088	T11089	auxpass	is,restricted
R7727	T11089	T11081	conj	restricted,is
R7728	T11090	T11089	prep	to,restricted
R7729	T11091	T11092	amod	dorsal,mesoderm
R7730	T11092	T11090	pobj	mesoderm,to
R7731	T11093	T11094	advmod	only,from
R7732	T11094	T11089	prep	from,restricted
R7733	T11095	T11094	pobj	E11.5,from
R7734	T11096	T11094	prep	to,from
R7735	T11097	T11096	pobj	E13.5,to
R7736	T11098	T11081	punct	.,is
R7737	T11100	T11101	nsubj	It,is
R7738	T11101	T11102	ccomp	is,require
R7739	T11103	T11101	acomp	possible,is
R7740	T11104	T11105	mark	that,influences
R7741	T11105	T11101	ccomp	influences,is
R7742	T11106	T11105	nsubj	Tbx15,influences
R7743	T11107	T11108	compound	skin,patterning
R7744	T11108	T11105	dobj	patterning,influences
R7745	T11109	T11105	prep	in,influences
R7746	T11110	T11111	det	a,window
R7747	T11111	T11109	pobj	window,in
R7748	T11112	T11113	advmod	very,narrow
R7749	T11113	T11111	amod	narrow,window
R7750	T11114	T11111	prep	of,window
R7751	T11115	T11114	pobj	development,of
R7752	T11116	T11102	punct	;,require
R7753	T11117	T11102	advmod	alternatively,require
R7754	T11118	T11102	punct	", ",require
R7755	T11119	T11102	nsubj	establishment,require
R7756	T11120	T11119	prep	of,establishment
R7757	T11121	T11122	amod	dorsal,identity
R7758	T11122	T11120	pobj	identity,of
R7759	T11123	T11119	prep	by,establishment
R7760	T11124	T11123	pobj	Tbx15,by
R7761	T11125	T11102	aux	may,require
R7762	T11126	T11127	det	another,factor
R7763	T11127	T11102	dobj	factor,require
R7764	T11128	T11129	advmod	as,yet
R7765	T11129	T11131	advmod	yet,unidentified
R7766	T11130	T11129	punct	-,yet
R7767	T11131	T11127	amod	unidentified,factor
R7768	T11132	T11131	punct	-,unidentified
R7769	T11133	T11134	dep	that,is
R7770	T11134	T11127	relcl	is,factor
R7771	T11135	T11134	advmod	only,is
R7772	T11136	T11134	acomp	present,is
R7773	T11137	T11134	prep	in,is
R7774	T11138	T11139	det	the,mesenchyme
R7775	T11139	T11137	pobj	mesenchyme,in
R7776	T11140	T11139	acl	underlying,mesenchyme
R7777	T11141	T11142	amod	dorsal,ectoderm
R7778	T11142	T11140	dobj	ectoderm,underlying
R7779	T11143	T11102	punct	.,require
R7780	T11305	T11306	compound	Pigmentation,Patterns
R7781	T11307	T11306	cc	and,Patterns
R7782	T11308	T11306	conj	Tbx15,Patterns
R7783	T11309	T11306	prep	in,Patterns
R7784	T11310	T11311	amod	Other,Mammals
R7785	T11311	T11309	pobj	Mammals,in
R7786	T11313	T11314	det	The,frontier
R7787	T11314	T11317	nsubjpass	frontier,established
R7788	T11315	T11314	amod	lateral,frontier
R7789	T11316	T11314	amod	somitic,frontier
R7790	T11318	T11314	punct	", ",frontier
R7791	T11319	T11314	acl	defined,frontier
R7792	T11320	T11319	prep	as,defined
R7793	T11321	T11322	det	the,boundary
R7794	T11322	T11320	pobj	boundary,as
R7795	T11323	T11322	compound	lineage,boundary
R7796	T11324	T11322	prep	between,boundary
R7797	T11325	T11326	npadvmod	somite,derived
R7798	T11326	T11328	amod	derived,mesoderm
R7799	T11327	T11326	punct	-,derived
R7800	T11328	T11324	pobj	mesoderm,between
R7801	T11329	T11326	cc	versus,derived
R7802	T11330	T11331	amod	lateral,plate
R7803	T11331	T11332	npadvmod	plate,derived
R7804	T11332	T11326	conj	derived,derived
R7805	T11333	T11332	punct	-,derived
R7806	T11334	T11317	punct	", ",established
R7807	T11335	T11317	auxpass	is,established
R7808	T11336	T11317	prep	during,established
R7809	T11337	T11336	pobj	somitogenesis,during
R7810	T11338	T11339	advmod	early,in
R7811	T11339	T11317	prep	in,established
R7812	T11340	T11339	pobj	development,in
R7813	T11341	T11342	punct	(,Mauger
R7814	T11342	T11317	meta	Mauger,established
R7815	T11343	T11342	nummod	1972,Mauger
R7816	T11344	T11342	punct	;,Mauger
R7817	T11345	T11342	nmod	Christ,Mauger
R7818	T11346	T11342	nmod	et,Mauger
R7819	T11347	T11342	nmod	al.,Mauger
R7820	T11348	T11342	nummod	1983,Mauger
R7821	T11349	T11342	punct	;,Mauger
R7822	T11350	T11342	nmod	Olivera,Mauger
R7823	T11351	T11342	punct	-,Mauger
R7824	T11352	T11342	nmod	Martinez,Mauger
R7825	T11353	T11342	nmod	et,Mauger
R7826	T11354	T11342	nmod	al.,Mauger
R7827	T11355	T11342	nummod	2000,Mauger
R7828	T11356	T11342	punct	;,Mauger
R7829	T11357	T11342	nmod	Nowicki,Mauger
R7830	T11358	T11342	nmod	et,Mauger
R7831	T11359	T11342	nmod	al.,Mauger
R7832	T11360	T11342	nummod	2003,Mauger
R7833	T11361	T11342	punct	),Mauger
R7834	T11362	T11317	punct	", ",established
R7835	T11363	T11317	cc	but,established
R7836	T11364	T11317	conj	remains,established
R7837	T11365	T11364	oprd	distinct,remains
R7838	T11366	T11364	prep	in,remains
R7839	T11367	T11368	amod	postnatal,animals
R7840	T11368	T11366	pobj	animals,in
R7841	T11369	T11364	prep	despite,remains
R7842	T11370	T11371	det	the,potential
R7843	T11371	T11369	pobj	potential,despite
R7844	T11372	T11371	prep	for,potential
R7845	T11373	T11374	amod	extensive,mixing
R7846	T11374	T11372	pobj	mixing,for
R7847	T11375	T11374	compound	cell,mixing
R7848	T11376	T11377	punct	(,see
R7849	T11377	T11364	parataxis	see,remains
R7850	T11378	T11377	dobj	Figure,see
R7851	T11379	T11378	nummod	8,Figure
R7852	T11380	T11377	punct	),see
R7853	T11381	T11317	punct	.,established
R7854	T11383	T11384	advmod	However,demonstrate
R7855	T11385	T11384	punct	", ",demonstrate
R7856	T11386	T11387	poss	our,studies
R7857	T11387	T11384	nsubj	studies,demonstrate
R7858	T11388	T11387	nmod	transplantation,studies
R7859	T11389	T11388	cc	and,transplantation
R7860	T11390	T11388	conj	fate,transplantation
R7861	T11391	T11390	punct	-,fate
R7862	T11392	T11390	amod	mapping,fate
R7863	T11393	T11394	mark	that,lies
R7864	T11394	T11384	ccomp	lies,demonstrate
R7865	T11395	T11396	det	the,frontier
R7866	T11396	T11394	nsubj	frontier,lies
R7867	T11397	T11396	amod	lateral,frontier
R7868	T11398	T11396	amod	somitic,frontier
R7869	T11399	T11394	advmod	dorsal,lies
R7870	T11400	T11399	prep	to,dorsal
R7871	T11401	T11402	det	the,boundary
R7872	T11402	T11400	pobj	boundary,to
R7873	T11403	T11402	compound	pigmentation,boundary
R7874	T11404	T11394	cc	and,lies
R7875	T11405	T11406	aux	does,correlate
R7876	T11406	T11394	conj	correlate,lies
R7877	T11407	T11406	neg	not,correlate
R7878	T11408	T11406	advmod	obviously,correlate
R7879	T11409	T11406	prep	with,correlate
R7880	T11410	T11411	det	a,difference
R7881	T11411	T11409	pobj	difference,with
R7882	T11412	T11411	prep	in,difference
R7883	T11413	T11414	compound	skin,morphology
R7884	T11414	T11412	pobj	morphology,in
R7885	T11415	T11384	punct	.,demonstrate
R7886	T11417	T11418	det	An,domain
R7887	T11418	T11421	nsubj	domain,emerged
R7888	T11419	T11418	amod	additional,domain
R7889	T11420	T11418	amod	dorsoventral,domain
R7890	T11422	T11423	dep	that,is
R7891	T11423	T11418	relcl	is,domain
R7892	T11424	T11423	neg	not,is
R7893	T11425	T11426	advmod	externally,apparent
R7894	T11426	T11423	acomp	apparent,is
R7895	T11427	T11421	aux	has,emerged
R7896	T11428	T11421	prep	from,emerged
R7897	T11429	T11428	pobj	studies,from
R7898	T11430	T11429	prep	of,studies
R7899	T11431	T11430	pobj	Msx1,of
R7900	T11432	T11431	punct	", ",Msx1
R7901	T11433	T11434	poss	whose,expression
R7902	T11434	T11435	dep	expression,marks
R7903	T11435	T11431	relcl	marks,Msx1
R7904	T11436	T11437	det	a,subgroup
R7905	T11437	T11435	dobj	subgroup,marks
R7906	T11438	T11437	prep	of,subgroup
R7907	T11439	T11440	npadvmod	somite,derived
R7908	T11440	T11442	amod	derived,cells
R7909	T11441	T11440	punct	-,derived
R7910	T11442	T11438	pobj	cells,of
R7911	T11443	T11442	amod	mesenchymal,cells
R7912	T11444	T11445	dep	that,contribute
R7913	T11445	T11437	relcl	contribute,subgroup
R7914	T11446	T11445	prep	to,contribute
R7915	T11447	T11446	pobj	dermis,to
R7916	T11448	T11445	prep	in,contribute
R7917	T11449	T11450	det	a,stripe
R7918	T11450	T11448	pobj	stripe,in
R7919	T11451	T11450	amod	narrow,stripe
R7920	T11452	T11450	prep	along,stripe
R7921	T11453	T11454	det	the,region
R7922	T11454	T11452	pobj	region,along
R7923	T11455	T11454	amod	paraspinal,region
R7924	T11456	T11457	punct	(,Houzelstein
R7925	T11457	T11421	meta	Houzelstein,emerged
R7926	T11458	T11457	nmod	et,Houzelstein
R7927	T11459	T11457	nmod	al.,Houzelstein
R7928	T11460	T11457	nummod	2000,Houzelstein
R7929	T11461	T11457	punct	),Houzelstein
R7930	T11462	T11421	punct	.,emerged
R7931	T11464	T11465	advmod	Thus,exist
R7932	T11466	T11465	punct	", ",exist
R7933	T11467	T11465	expl	there,exist
R7934	T11468	T11469	advmod	at,three
R7935	T11469	T11471	nummod	three,boundaries
R7936	T11470	T11469	advmod	least,three
R7937	T11471	T11465	dobj	boundaries,exist
R7938	T11472	T11471	amod	distinct,boundaries
R7939	T11473	T11471	prep	in,boundaries
R7940	T11474	T11475	amod	postnatal,skin
R7941	T11475	T11473	pobj	skin,in
R7942	T11476	T11475	amod	mammalian,skin
R7943	T11477	T11478	dep	that,are
R7944	T11478	T11471	relcl	are,boundaries
R7945	T11479	T11478	acomp	parallel,are
R7946	T11480	T11479	prep	to,parallel
R7947	T11481	T11482	det	the,plane
R7948	T11482	T11480	pobj	plane,to
R7949	T11483	T11482	amod	sagittal,plane
R7950	T11484	T11471	punct	", ",boundaries
R7951	T11485	T11471	acl	marked,boundaries
R7952	T11486	T11485	agent	by,marked
R7953	T11487	T11486	pobj	differences,by
R7954	T11488	T11487	prep	in,differences
R7955	T11489	T11490	compound	pigment,type
R7956	T11490	T11492	compound	type,synthesis
R7957	T11491	T11490	punct	-,type
R7958	T11492	T11488	pobj	synthesis,in
R7959	T11493	T11487	punct	", ",differences
R7960	T11494	T11487	conj	differences,differences
R7961	T11495	T11494	prep	in,differences
R7962	T11496	T11497	compound	cell,lineage
R7963	T11497	T11495	pobj	lineage,in
R7964	T11498	T11494	punct	", ",differences
R7965	T11499	T11494	cc	and,differences
R7966	T11500	T11494	conj	differences,differences
R7967	T11501	T11500	prep	in,differences
R7968	T11502	T11501	pobj	expression,in
R7969	T11503	T11502	prep	of,expression
R7970	T11504	T11503	pobj	Msx1,of
R7971	T11505	T11465	punct	.,exist
R7972	T11507	T11508	prep	In,is
R7973	T11509	T11507	pobj	rodents,In
R7974	T11510	T11508	punct	", ",is
R7975	T11511	T11512	advmod	only,boundary
R7976	T11512	T11508	nsubj	boundary,is
R7977	T11513	T11512	det	the,boundary
R7978	T11514	T11512	compound	pigmentation,boundary
R7979	T11515	T11508	acomp	evident,is
R7980	T11516	T11508	advmod	externally,is
R7981	T11517	T11508	punct	", ",is
R7982	T11518	T11508	cc	but,is
R7983	T11519	T11520	amod	many,mammals
R7984	T11520	T11521	nsubj	mammals,have
R7985	T11521	T11508	conj	have,is
R7986	T11522	T11523	advmod	more,complicated
R7987	T11523	T11524	amod	complicated,patterns
R7988	T11524	T11521	dobj	patterns,have
R7989	T11525	T11524	prep	of,patterns
R7990	T11526	T11527	compound	hair,type
R7991	T11527	T11525	pobj	type,of
R7992	T11528	T11527	punct	", ",type
R7993	T11529	T11527	conj	length,type
R7994	T11530	T11529	punct	", ",length
R7995	T11531	T11529	cc	and,length
R7996	T11532	T11531	punct	/,and
R7997	T11533	T11531	cc	or,and
R7998	T11534	T11529	conj	color,length
R7999	T11535	T11536	dep	that,vary
R8000	T11536	T11524	relcl	vary,patterns
R8001	T11537	T11536	prep	along,vary
R8002	T11538	T11539	det	the,axis
R8003	T11539	T11537	pobj	axis,along
R8004	T11540	T11539	amod	dorsoventral,axis
R8005	T11541	T11521	punct	.,have
R8006	T11543	T11544	nsubj	Raccoons,exhibit
R8007	T11545	T11543	punct	", ",Raccoons
R8008	T11546	T11543	conj	squirrels,Raccoons
R8009	T11547	T11546	punct	", ",squirrels
R8010	T11548	T11546	conj	skunks,squirrels
R8011	T11549	T11548	punct	", ",skunks
R8012	T11550	T11548	cc	and,skunks
R8013	T11551	T11552	amod	many,ungulates
R8014	T11552	T11548	conj	ungulates,skunks
R8015	T11553	T11552	amod	different,ungulates
R8016	T11554	T11555	amod	lateral,stripes
R8017	T11555	T11544	dobj	stripes,exhibit
R8018	T11556	T11557	poss	whose,origins
R8019	T11557	T11559	dep	origins,investigated
R8020	T11558	T11557	amod	developmental,origins
R8021	T11559	T11555	relcl	investigated,stripes
R8022	T11560	T11559	aux	have,investigated
R8023	T11561	T11559	neg	not,investigated
R8024	T11562	T11559	auxpass	been,investigated
R8025	T11563	T11559	punct	", ",investigated
R8026	T11564	T11559	cc	but,investigated
R8027	T11565	T11566	aux	may,correspond
R8028	T11566	T11559	conj	correspond,investigated
R8029	T11567	T11566	prep	to,correspond
R8030	T11568	T11569	det	the,frontier
R8031	T11569	T11567	pobj	frontier,to
R8032	T11570	T11569	amod	lateral,frontier
R8033	T11571	T11569	amod	somitic,frontier
R8034	T11572	T11569	punct	", ",frontier
R8035	T11573	T11574	det	the,compartment
R8036	T11574	T11569	conj	compartment,frontier
R8037	T11575	T11574	amod	paraspinal,compartment
R8038	T11576	T11574	compound	Msx1,compartment
R8039	T11577	T11574	punct	", ",compartment
R8040	T11578	T11574	cc	or,compartment
R8041	T11579	T11580	det	an,interaction
R8042	T11580	T11574	conj	interaction,compartment
R8043	T11581	T11580	prep	between,interaction
R8044	T11582	T11583	det	these,domains
R8045	T11583	T11581	pobj	domains,between
R8046	T11584	T11544	punct	.,exhibit
R8047	T11586	T11587	det	The,effect
R8048	T11587	T11588	nsubj	effect,is
R8049	T11589	T11587	prep	of,effect
R8050	T11590	T11589	pobj	Tbx15,of
R8051	T11591	T11587	prep	on,effect
R8052	T11592	T11591	pobj	pigmentation,on
R8053	T11593	T11587	prep	in,effect
R8054	T11594	T11595	compound	laboratory,mice
R8055	T11595	T11593	pobj	mice,in
R8056	T11596	T11588	acomp	reminiscent,is
R8057	T11597	T11596	prep	of,reminiscent
R8058	T11598	T11599	compound	coat,color
R8059	T11599	T11601	compound	color,patterns
R8060	T11600	T11599	punct	-,color
R8061	T11601	T11597	pobj	patterns,of
R8062	T11602	T11601	prep	in,patterns
R8063	T11603	T11604	preconj	both,selected
R8064	T11604	T11605	amod	selected,populations
R8065	T11605	T11602	pobj	populations,in
R8066	T11606	T11604	cc	and,selected
R8067	T11607	T11604	conj	natural,selected
R8068	T11608	T11605	prep	of,populations
R8069	T11609	T11610	amod	other,mammals
R8070	T11610	T11608	pobj	mammals,of
R8071	T11611	T11588	punct	.,is
R8072	T11613	T11614	compound	Saddle,markings
R8073	T11614	T11615	nsubj	markings,are
R8074	T11616	T11615	acomp	common,are
R8075	T11617	T11615	prep	in,are
R8076	T11618	T11619	det	some,breeds
R8077	T11619	T11617	pobj	breeds,in
R8078	T11620	T11619	compound	dog,breeds
R8079	T11621	T11619	punct	", ",breeds
R8080	T11622	T11623	amod	such,as
R8081	T11623	T11619	prep	as,breeds
R8082	T11624	T11625	compound	German,shepherds
R8083	T11625	T11623	pobj	shepherds,as
R8084	T11626	T11617	punct	", ",in
R8085	T11627	T11617	cc	and,in
R8086	T11628	T11617	conj	in,in
R8087	T11629	T11630	amod	certain,populations
R8088	T11630	T11628	pobj	populations,in
R8089	T11631	T11630	prep	of,populations
R8090	T11632	T11633	compound	Peromyscus,polionotus
R8091	T11633	T11631	pobj	polionotus,of
R8092	T11634	T11630	punct	", ",populations
R8093	T11635	T11636	prep	in,provides
R8094	T11636	T11630	relcl	provides,populations
R8095	T11637	T11635	pobj	which,in
R8096	T11638	T11639	det	a,extension
R8097	T11639	T11636	nsubj	extension,provides
R8098	T11640	T11639	amod	dorsal,extension
R8099	T11641	T11639	prep	of,extension
R8100	T11642	T11643	amod	ventral,depigmentation
R8101	T11643	T11641	pobj	depigmentation,of
R8102	T11644	T11645	det	an,advantage
R8103	T11645	T11636	dobj	advantage,provides
R8104	T11646	T11645	amod	adaptive,advantage
R8105	T11647	T11636	dative	to,provides
R8106	T11648	T11647	pobj	subspecies,to
R8107	T11649	T11650	dep	that,live
R8108	T11650	T11648	relcl	live,subspecies
R8109	T11651	T11650	prep	on,live
R8110	T11652	T11653	amod	white,reefs
R8111	T11653	T11651	pobj	reefs,on
R8112	T11654	T11653	compound	sand,reefs
R8113	T11655	T11656	punct	(,Blair
R8114	T11656	T11615	meta	Blair,are
R8115	T11657	T11656	nummod	1951,Blair
R8116	T11658	T11656	punct	;,Blair
R8117	T11659	T11656	conj	Kaufman,Blair
R8118	T11660	T11659	nummod	1974,Kaufman
R8119	T11661	T11659	punct	;,Kaufman
R8120	T11662	T11659	conj	Belk,Kaufman
R8121	T11663	T11662	cc	and,Belk
R8122	T11664	T11662	conj	Smith,Belk
R8123	T11665	T11664	nummod	1996,Smith
R8124	T11666	T11664	punct	),Smith
R8125	T11667	T11615	punct	.,are
R8126	T11669	T11670	preconj	Neither,shepherds
R8127	T11670	T11672	nsubj	shepherds,have
R8128	T11671	T11670	compound	German,shepherds
R8129	T11673	T11670	cc	nor,shepherds
R8130	T11674	T11675	compound	deer,mice
R8131	T11675	T11670	conj	mice,shepherds
R8132	T11676	T11677	amod	craniofacial,characteristics
R8133	T11677	T11672	dobj	characteristics,have
R8134	T11678	T11677	amod	similar,characteristics
R8135	T11679	T11678	prep	to,similar
R8136	T11680	T11681	det	the,mutation
R8137	T11681	T11679	pobj	mutation,to
R8138	T11682	T11681	compound	deH,mutation
R8139	T11683	T11672	punct	", ",have
R8140	T11684	T11672	cc	but,have
R8141	T11685	T11686	det	the,patterns
R8142	T11686	T11688	nsubj	patterns,represent
R8143	T11687	T11686	compound	pigmentation,patterns
R8144	T11688	T11672	conj	represent,have
R8145	T11689	T11686	prep	in,patterns
R8146	T11690	T11691	det	these,animals
R8147	T11691	T11689	pobj	animals,in
R8148	T11692	T11688	aux	could,represent
R8149	T11693	T11688	dobj	alterations,represent
R8150	T11694	T11693	prep	in,alterations
R8151	T11695	T11696	det	the,regulation
R8152	T11696	T11694	pobj	regulation,in
R8153	T11697	T11696	cc	or,regulation
R8154	T11698	T11696	conj	action,regulation
R8155	T11699	T11696	prep	of,regulation
R8156	T11700	T11701	compound	Tbx15,activity
R8157	T11701	T11699	pobj	activity,of
R8158	T11702	T11688	punct	.,represent
R8159	T11704	T11705	prep	From,are
R8160	T11706	T11707	det	the,perspective
R8161	T11707	T11704	pobj	perspective,From
R8162	T11708	T11707	amod	opposite,perspective
R8163	T11709	T11705	punct	", ",are
R8164	T11710	T11711	det	the,effects
R8165	T11711	T11705	nsubj	effects,are
R8166	T11712	T11711	prep	of,effects
R8167	T11713	T11712	pobj	Tbx15,of
R8168	T11714	T11711	prep	on,effects
R8169	T11715	T11716	compound	coat,color
R8170	T11716	T11714	pobj	color,on
R8171	T11717	T11705	advmod	only,are
R8172	T11718	T11705	acomp	apparent,are
R8173	T11719	T11705	prep	in,are
R8174	T11720	T11721	amod	certain,backgrounds
R8175	T11721	T11719	pobj	backgrounds,in
R8176	T11722	T11721	amod	genetic,backgrounds
R8177	T11723	T11705	cc	and,are
R8178	T11724	T11725	aux	may,be
R8179	T11725	T11705	conj	be,are
R8180	T11726	T11725	neg	not,be
R8181	T11727	T11725	acomp	evident,be
R8182	T11728	T11729	advmod	at,all
R8183	T11729	T11725	advmod	all,be
R8184	T11730	T11725	prep	in,be
R8185	T11731	T11730	pobj	mammals,in
R8186	T11732	T11733	dep	that,lack
R8187	T11733	T11731	relcl	lack,mammals
R8188	T11734	T11735	amod	dorsoventral,patterns
R8189	T11735	T11733	dobj	patterns,lack
R8190	T11736	T11735	compound	pigmentation,patterns
R8191	T11737	T11705	punct	.,are
R8192	T11739	T11740	csubj	Studying,provide
R8193	T11741	T11742	det	the,sequence
R8194	T11742	T11739	dobj	sequence,Studying
R8195	T11743	T11742	cc	and,sequence
R8196	T11744	T11742	conj	expression,sequence
R8197	T11745	T11742	prep	of,sequence
R8198	T11746	T11745	pobj	Tbx15,of
R8199	T11747	T11739	prep	in,Studying
R8200	T11748	T11749	amod	other,vertebrates
R8201	T11749	T11747	pobj	vertebrates,in
R8202	T11750	T11740	aux	may,provide
R8203	T11751	T11752	amod	additional,insight
R8204	T11752	T11740	dobj	insight,provide
R8205	T11753	T11752	prep	into,insight
R8206	T11754	T11753	pobj	patterns,into
R8207	T11755	T11756	dep	that,affect
R8208	T11756	T11754	relcl	affect,patterns
R8209	T11757	T11758	det	the,skeleton
R8210	T11758	T11756	dobj	skeleton,affect
R8211	T11759	T11760	advmod	as,as
R8212	T11760	T11758	cc	as,skeleton
R8213	T11761	T11760	advmod	well,as
R8214	T11762	T11763	det	the,system
R8215	T11763	T11758	conj	system,skeleton
R8216	T11764	T11763	amod	pigmentary,system
R8217	T11765	T11740	punct	.,provide
R8218	T11801	T11802	det	All,mice
R8219	T11802	T11803	nsubjpass	mice,obtained
R8220	T11804	T11803	auxpass	were,obtained
R8221	T11805	T11803	advmod	originally,obtained
R8222	T11806	T11803	prep	from,obtained
R8223	T11807	T11808	det	The,Laboratory
R8224	T11808	T11806	pobj	Laboratory,from
R8225	T11809	T11808	compound	Jackson,Laboratory
R8226	T11810	T11811	punct	(,Harbor
R8227	T11811	T11808	parataxis	Harbor,Laboratory
R8228	T11812	T11811	compound	Bar,Harbor
R8229	T11813	T11811	punct	", ",Harbor
R8230	T11814	T11811	npadvmod	Maine,Harbor
R8231	T11815	T11811	punct	", ",Harbor
R8232	T11816	T11817	compound	United,States
R8233	T11817	T11811	npadvmod	States,Harbor
R8234	T11818	T11811	punct	),Harbor
R8235	T11819	T11803	punct	", ",obtained
R8236	T11820	T11803	prep	except,obtained
R8237	T11821	T11822	det	the,strain
R8238	T11822	T11820	pobj	strain,except
R8239	T11823	T11822	compound	BA,strain
R8240	T11824	T11825	punct	(,Center
R8241	T11825	T11822	parataxis	Center,strain
R8242	T11826	T11825	compound	Stanford,Center
R8243	T11827	T11828	compound	Veterinary,Services
R8244	T11828	T11825	compound	Services,Center
R8245	T11829	T11825	punct	", ",Center
R8246	T11830	T11825	npadvmod	Stanford,Center
R8247	T11831	T11825	punct	", ",Center
R8248	T11832	T11825	npadvmod	California,Center
R8249	T11833	T11825	punct	", ",Center
R8250	T11834	T11835	compound	United,States
R8251	T11835	T11825	npadvmod	States,Center
R8252	T11836	T11825	punct	),Center
R8253	T11837	T11822	punct	", ",strain
R8254	T11838	T11839	nmod	Hoxb6,Cre
R8255	T11839	T11841	nmod	Cre,mice
R8256	T11840	T11839	punct	-,Cre
R8257	T11841	T11822	conj	mice,strain
R8258	T11842	T11841	amod	transgenic,mice
R8259	T11843	T11841	punct	(,mice
R8260	T11844	T11845	advmod	kindly,provided
R8261	T11845	T11841	acl	provided,mice
R8262	T11846	T11845	agent	by,provided
R8263	T11847	T11848	compound	M.,Kuehn
R8264	T11848	T11846	pobj	Kuehn,by
R8265	T11849	T11848	prep	of,Kuehn
R8266	T11850	T11851	det	the,Institutes
R8267	T11851	T11849	pobj	Institutes,of
R8268	T11852	T11851	compound	National,Institutes
R8269	T11853	T11851	prep	of,Institutes
R8270	T11854	T11853	pobj	Health,of
R8271	T11855	T11851	punct	", ",Institutes
R8272	T11856	T11851	npadvmod	Bethesda,Institutes
R8273	T11857	T11851	punct	", ",Institutes
R8274	T11858	T11851	npadvmod	Maryland,Institutes
R8275	T11859	T11851	punct	", ",Institutes
R8276	T11860	T11861	compound	United,States
R8277	T11861	T11851	npadvmod	States,Institutes
R8278	T11862	T11841	punct	),mice
R8279	T11863	T11841	punct	", ",mice
R8280	T11864	T11841	conj	mice,mice
R8281	T11865	T11864	acl	carrying,mice
R8282	T11866	T11867	det	the,allele
R8283	T11867	T11865	dobj	allele,carrying
R8284	T11868	T11869	compound	R26R,reporter
R8285	T11869	T11867	compound	reporter,allele
R8286	T11870	T11869	compound	lacZ,reporter
R8287	T11871	T11864	punct	(,mice
R8288	T11872	T11873	advmod	kindly,provided
R8289	T11873	T11864	acl	provided,mice
R8290	T11874	T11873	agent	by,provided
R8291	T11875	T11876	compound	P.,Soriano
R8292	T11876	T11874	pobj	Soriano,by
R8293	T11877	T11876	punct	", ",Soriano
R8294	T11878	T11879	compound	Fred,Center
R8295	T11879	T11876	appos	Center,Soriano
R8296	T11880	T11879	compound	Hutchinson,Center
R8297	T11881	T11882	compound	Cancer,Research
R8298	T11882	T11879	compound	Research,Center
R8299	T11883	T11879	punct	", ",Center
R8300	T11884	T11879	npadvmod	Seattle,Center
R8301	T11885	T11879	punct	", ",Center
R8302	T11886	T11879	npadvmod	Washington,Center
R8303	T11887	T11879	punct	", ",Center
R8304	T11888	T11889	compound	United,States
R8305	T11889	T11879	npadvmod	States,Center
R8306	T11890	T11864	punct	),mice
R8307	T11891	T11864	punct	", ",mice
R8308	T11892	T11864	cc	and,mice
R8309	T11893	T11894	nmod	C57BL,6J
R8310	T11894	T11896	nmod	6J,mice
R8311	T11895	T11894	punct	/,6J
R8312	T11896	T11864	conj	mice,mice
R8313	T11897	T11894	punct	(,6J
R8314	T11898	T11894	appos	B6,6J
R8315	T11899	T11894	punct	),6J
R8316	T11900	T11901	compound	ae,ae
R8317	T11901	T11896	compound	ae,mice
R8318	T11902	T11901	punct	/,ae
R8319	T11903	T11896	punct	(,mice
R8320	T11904	T11905	advmod	kindly,provided
R8321	T11905	T11896	acl	provided,mice
R8322	T11906	T11905	agent	by,provided
R8323	T11907	T11908	compound	L.,Siracusa
R8324	T11908	T11906	pobj	Siracusa,by
R8325	T11909	T11908	punct	", ",Siracusa
R8326	T11910	T11911	compound	Jefferson,College
R8327	T11911	T11908	appos	College,Siracusa
R8328	T11912	T11911	compound	Medical,College
R8329	T11913	T11911	punct	", ",College
R8330	T11914	T11911	npadvmod	Philadelphia,College
R8331	T11915	T11911	punct	", ",College
R8332	T11916	T11911	npadvmod	Pennsylvania,College
R8333	T11917	T11911	punct	", ",College
R8334	T11918	T11919	compound	United,States
R8335	T11919	T11911	npadvmod	States,College
R8336	T11920	T11896	punct	),mice
R8337	T11921	T11803	punct	.,obtained
R8338	T11923	T11924	det	The,mutation
R8339	T11924	T11926	nsubj	mutation,arose
R8340	T11925	T11924	compound	deH,mutation
R8341	T11927	T11926	prep	in,arose
R8342	T11928	T11929	det	the,1960s
R8343	T11929	T11927	pobj	1960s,in
R8344	T11930	T11926	prep	in,arose
R8345	T11931	T11930	pobj	Harwell,in
R8346	T11932	T11926	punct	", ",arose
R8347	T11933	T11934	advmod	probably,on
R8348	T11934	T11926	prep	on,arose
R8349	T11935	T11936	det	the,background
R8350	T11936	T11934	pobj	background,on
R8351	T11937	T11938	compound	BN,strain
R8352	T11938	T11936	compound	strain,background
R8353	T11939	T11940	punct	(,C.
R8354	T11940	T11926	meta	C.,arose
R8355	T11941	T11940	nmod	Beechey,C.
R8356	T11942	T11940	punct	", ",C.
R8357	T11943	T11940	amod	personal,C.
R8358	T11944	T11940	nmod	communication,C.
R8359	T11945	T11940	punct	),C.
R8360	T11946	T11926	punct	.,arose
R8361	T11948	T11949	nsubj	We,obtained
R8362	T11950	T11949	dobj	deH,obtained
R8363	T11951	T11950	prep	on,deH
R8364	T11952	T11953	det	a,background
R8365	T11953	T11951	pobj	background,on
R8366	T11954	T11955	compound	B6,EiC3H
R8367	T11955	T11953	compound	EiC3H,background
R8368	T11956	T11955	punct	/,EiC3H
R8369	T11957	T11949	punct	", ",obtained
R8370	T11958	T11949	conj	introduced,obtained
R8371	T11959	T11960	det	the,allele
R8372	T11960	T11958	dobj	allele,introduced
R8373	T11961	T11960	compound	at,allele
R8374	T11962	T11960	prep	from,allele
R8375	T11963	T11964	det	the,strain
R8376	T11964	T11962	pobj	strain,from
R8377	T11965	T11964	compound	BTBR,strain
R8378	T11966	T11958	punct	", ",introduced
R8379	T11967	T11958	cc	and,introduced
R8380	T11968	T11969	aux	have,maintained
R8381	T11969	T11958	conj	maintained,introduced
R8382	T11970	T11971	det	the,line
R8383	T11971	T11969	dobj	line,maintained
R8384	T11972	T11969	prep	as,maintained
R8385	T11973	T11974	det	a,stock
R8386	T11974	T11972	pobj	stock,as
R8387	T11975	T11974	amod	mixed,stock
R8388	T11976	T11974	nmod	deH,stock
R8389	T11977	T11976	punct	/,deH
R8390	T11978	T11976	punct	+,deH
R8391	T11979	T11976	punct	×,deH
R8392	T11980	T11976	appos	deH,deH
R8393	T11981	T11980	punct	/,deH
R8394	T11982	T11980	punct	+,deH
R8395	T11983	T11976	amod	intercross,deH
R8396	T11984	T11969	prep	with,maintained
R8397	T11985	T11986	amod	periodic,outcrossing
R8398	T11986	T11984	pobj	outcrossing,with
R8399	T11987	T11986	prep	to,outcrossing
R8400	T11988	T11987	pobj	BTBR,to
R8401	T11989	T11988	cc	or,BTBR
R8402	T11990	T11988	conj	B6,BTBR
R8403	T11991	T11949	punct	.,obtained
R8404	T11993	T11994	prep	For,considered
R8405	T11995	T11996	amod	timed,matings
R8406	T11996	T11993	pobj	matings,For
R8407	T11997	T11994	punct	", ",considered
R8408	T11998	T11999	det	the,morning
R8409	T11999	T11994	nsubjpass	morning,considered
R8410	T12000	T11999	prep	of,morning
R8411	T12001	T12002	det	the,plug
R8412	T12002	T12000	pobj	plug,of
R8413	T12003	T11994	auxpass	was,considered
R8414	T12004	T11994	oprd	E0.5,considered
R8415	T12005	T11994	punct	.,considered
R8416	T12007	T12008	advmod	Postnatally,considered
R8417	T12009	T12008	punct	", ",considered
R8418	T12010	T12011	det	the,day
R8419	T12011	T12008	nsubjpass	day,considered
R8420	T12012	T12011	prep	of,day
R8421	T12013	T12012	pobj	birth,of
R8422	T12014	T12008	auxpass	was,considered
R8423	T12015	T12016	aux	to,be
R8424	T12016	T12008	xcomp	be,considered
R8425	T12017	T12016	attr	P0.5,be
R8426	T12018	T12008	punct	.,considered
R8429	T12097	T12098	amod	Phenotypic,analysis
R8430	T12100	T12101	prep	For,dissected
R8431	T12102	T12100	pobj	measurements,For
R8432	T12103	T12102	prep	of,measurements
R8433	T12104	T12105	compound	hair,length
R8434	T12105	T12103	pobj	length,of
R8435	T12106	T12105	cc	and,length
R8436	T12107	T12105	conj	color,length
R8437	T12108	T12101	punct	", ",dissected
R8438	T12109	T12110	det	the,region
R8439	T12110	T12101	nsubjpass	region,dissected
R8440	T12111	T12110	amod	entire,region
R8441	T12112	T12110	compound	interlimb,region
R8442	T12113	T12110	prep	of,region
R8443	T12114	T12113	pobj	skin,of
R8444	T12115	T12101	auxpass	was,dissected
R8445	T12116	T12101	advmod	first,dissected
R8446	T12117	T12101	prep	with,dissected
R8447	T12118	T12119	det	a,incision
R8448	T12119	T12117	pobj	incision,with
R8449	T12120	T12119	amod	single,incision
R8450	T12121	T12119	prep	at,incision
R8451	T12122	T12123	det	the,midline
R8452	T12123	T12121	pobj	midline,at
R8453	T12124	T12123	amod	dorsal,midline
R8454	T12125	T12101	cc	and,dissected
R8455	T12126	T12101	conj	preserved,dissected
R8456	T12127	T12126	prep	with,preserved
R8457	T12128	T12129	amod	powdered,bicarbonate
R8458	T12129	T12127	pobj	bicarbonate,with
R8459	T12130	T12129	compound	sodium,bicarbonate
R8460	T12131	T12101	punct	.,dissected
R8461	T12133	T12134	nsubjpass	Slices,prepared
R8462	T12135	T12136	compound	2,2.5
R8463	T12136	T12138	nummod	2.5,mm
R8464	T12137	T12136	punct	–,2.5
R8465	T12138	T12139	nsubj	mm,in
R8466	T12139	T12133	relcl	in,Slices
R8467	T12140	T12139	pobj	width,in
R8468	T12141	T12134	auxpass	were,prepared
R8469	T12142	T12134	advmod	then,prepared
R8470	T12143	T12134	advmod	parallel,prepared
R8471	T12144	T12143	prep	to,parallel
R8472	T12145	T12146	det	the,axis
R8473	T12146	T12144	pobj	axis,to
R8474	T12147	T12146	amod	dorsoventral,axis
R8475	T12148	T12134	punct	", ",prepared
R8476	T12149	T12150	compound	hair,boundaries
R8477	T12150	T12152	nsubj	boundaries,determined
R8478	T12151	T12150	compound	length,boundaries
R8479	T12152	T12134	conj	determined,prepared
R8480	T12153	T12152	prep	from,determined
R8481	T12154	T12155	amod	electronic,images
R8482	T12155	T12153	pobj	images,from
R8483	T12156	T12152	prep	with,determined
R8484	T12157	T12158	compound	Adobe,Photoshop
R8485	T12158	T12156	pobj	Photoshop,with
R8486	T12159	T12160	punct	(,Jose
R8487	T12160	T12158	parataxis	Jose,Photoshop
R8488	T12161	T12160	compound	San,Jose
R8489	T12162	T12160	punct	", ",Jose
R8490	T12163	T12160	npadvmod	California,Jose
R8491	T12164	T12160	punct	", ",Jose
R8492	T12165	T12166	compound	United,States
R8493	T12166	T12160	npadvmod	States,Jose
R8494	T12167	T12160	punct	),Jose
R8495	T12168	T12152	punct	", ",determined
R8496	T12169	T12152	cc	and,determined
R8497	T12170	T12171	nsubj	measurements,obtained
R8498	T12171	T12152	conj	obtained,determined
R8499	T12172	T12171	advcl	using,obtained
R8500	T12173	T12172	dobj	ImageJ,using
R8501	T12174	T12175	punct	(,Institutes
R8502	T12175	T12173	parataxis	Institutes,ImageJ
R8503	T12176	T12175	compound	National,Institutes
R8504	T12177	T12175	prep	of,Institutes
R8505	T12178	T12177	pobj	Health,of
R8506	T12179	T12175	punct	),Institutes
R8507	T12180	T12171	punct	.,obtained
R8508	T12182	T12183	det	This,approach
R8509	T12183	T12184	nsubj	approach,samples
R8510	T12185	T12184	dobj	awls,samples
R8511	T12186	T12185	cc	and,awls
R8512	T12187	T12185	conj	auchenes,awls
R8513	T12188	T12184	punct	", ",samples
R8514	T12189	T12190	mark	because,are
R8515	T12190	T12184	advcl	are,samples
R8516	T12191	T12190	nsubj	they,are
R8517	T12192	T12193	advmod	much,thicker
R8518	T12193	T12190	acomp	thicker,are
R8519	T12194	T12193	cc	and,thicker
R8520	T12195	T12196	advmod	therefore,predominant
R8521	T12196	T12193	conj	predominant,thicker
R8522	T12197	T12196	advmod	visually,predominant
R8523	T12198	T12196	advmod	more,predominant
R8524	T12199	T12193	prep	than,thicker
R8525	T12200	T12201	compound	zigzag,underhairs
R8526	T12201	T12199	pobj	underhairs,than
R8527	T12202	T12184	punct	.,samples
R8528	T12204	T12205	aux	To,assess
R8529	T12205	T12206	advcl	assess,plucked
R8530	T12207	T12208	amod	dorsoventral,variation
R8531	T12208	T12205	dobj	variation,assess
R8532	T12209	T12208	prep	in,variation
R8533	T12210	T12211	compound	hair,type
R8534	T12211	T12213	compound	type,distribution
R8535	T12212	T12211	punct	-,type
R8536	T12213	T12209	pobj	distribution,in
R8537	T12214	T12206	punct	", ",plucked
R8538	T12215	T12216	amod	several,hairs
R8539	T12216	T12206	nsubjpass	hairs,plucked
R8540	T12217	T12216	nummod	hundred,hairs
R8541	T12218	T12206	auxpass	were,plucked
R8542	T12219	T12206	prep	from,plucked
R8543	T12220	T12221	det	the,middorsum
R8544	T12221	T12219	pobj	middorsum,from
R8545	T12222	T12221	cc	or,middorsum
R8546	T12223	T12221	conj	midventrum,middorsum
R8547	T12224	T12221	prep	of,middorsum
R8548	T12225	T12226	nummod	8,wk
R8549	T12226	T12228	npadvmod	wk,old
R8550	T12227	T12226	punct	-,wk
R8551	T12228	T12230	amod	old,animals
R8552	T12229	T12228	punct	-,old
R8553	T12230	T12224	pobj	animals,of
R8554	T12231	T12230	amod	male,animals
R8555	T12232	T12233	compound	BA,strain
R8556	T12233	T12230	compound	strain,animals
R8557	T12234	T12206	punct	", ",plucked
R8558	T12235	T12236	advmod	then,sorted
R8559	T12236	T12206	dep	sorted,plucked
R8560	T12237	T12236	cc	and,sorted
R8561	T12238	T12236	conj	categorized,sorted
R8562	T12239	T12236	advcl	using,sorted
R8563	T12240	T12241	det	a,microscope
R8564	T12241	T12239	dobj	microscope,using
R8565	T12242	T12241	compound	dissection,microscope
R8566	T12243	T12206	punct	.,plucked
R8567	T12245	T12246	det	No,attempt
R8568	T12246	T12247	nsubjpass	attempt,made
R8569	T12248	T12247	auxpass	was,made
R8570	T12249	T12250	aux	to,distinguish
R8571	T12250	T12247	xcomp	distinguish,made
R8572	T12251	T12250	prep	between,distinguish
R8573	T12252	T12251	pobj	awls,between
R8574	T12253	T12252	cc	and,awls
R8575	T12254	T12252	conj	auchenes,awls
R8576	T12255	T12247	punct	.,made
R8577	T12257	T12258	prep	For,stained
R8578	T12259	T12260	compound	skin,histology
R8579	T12260	T12257	pobj	histology,For
R8580	T12261	T12258	punct	", ",stained
R8581	T12262	T12263	nummod	12,μm
R8582	T12263	T12264	compound	μm,sections
R8583	T12264	T12258	nsubjpass	sections,stained
R8584	T12265	T12264	prep	from,sections
R8585	T12266	T12267	npadvmod	paraffin,embedded
R8586	T12267	T12269	amod	embedded,tissue
R8587	T12268	T12267	punct	-,embedded
R8588	T12269	T12265	pobj	tissue,from
R8589	T12270	T12258	auxpass	were,stained
R8590	T12271	T12258	prep	with,stained
R8591	T12272	T12271	pobj	hematoxylin,with
R8592	T12273	T12272	cc	and,hematoxylin
R8593	T12274	T12272	conj	eosin,hematoxylin
R8594	T12275	T12258	punct	.,stained
R8595	T12277	T12278	prep	For,split
R8596	T12279	T12280	compound	DOPA,staining
R8597	T12280	T12277	pobj	staining,For
R8598	T12281	T12278	punct	", ",split
R8599	T12282	T12283	det	the,dermis
R8600	T12283	T12278	nsubjpass	dermis,split
R8601	T12284	T12283	cc	and,dermis
R8602	T12285	T12283	conj	epidermis,dermis
R8603	T12286	T12278	auxpass	were,split
R8604	T12287	T12278	prep	after,split
R8605	T12288	T12289	nummod	3,h
R8606	T12289	T12287	pobj	h,after
R8607	T12290	T12289	prep	of,h
R8608	T12291	T12290	pobj	incubation,of
R8609	T12292	T12291	prep	in,incubation
R8610	T12293	T12294	nummod	2,M
R8611	T12294	T12295	compound	M,bromide
R8612	T12295	T12292	pobj	bromide,in
R8613	T12296	T12295	compound	sodium,bromide
R8614	T12297	T12291	prep	at,incubation
R8615	T12298	T12299	nummod	37,°C
R8616	T12299	T12297	pobj	°C,at
R8617	T12300	T12301	punct	(,causes
R8618	T12301	T12291	parataxis	causes,incubation
R8619	T12302	T12303	det	this,preparation
R8620	T12303	T12301	nsubj	preparation,causes
R8621	T12304	T12305	amod	most,follicles
R8622	T12305	T12307	nsubj	follicles,remain
R8623	T12306	T12305	compound	hair,follicles
R8624	T12307	T12301	ccomp	remain,causes
R8625	T12308	T12307	aux	to,remain
R8626	T12309	T12307	prep	with,remain
R8627	T12310	T12311	det	the,dermis
R8628	T12311	T12309	pobj	dermis,with
R8629	T12312	T12301	punct	),causes
R8630	T12313	T12278	punct	", ",split
R8631	T12314	T12315	advmod	individually,fixed
R8632	T12315	T12278	dep	fixed,split
R8633	T12316	T12315	prep	for,fixed
R8634	T12317	T12318	nummod	1,h
R8635	T12318	T12316	pobj	h,for
R8636	T12319	T12278	punct	", ",split
R8637	T12320	T12321	advmod	then,rinsed
R8638	T12321	T12278	dep	rinsed,split
R8639	T12322	T12321	cc	and,rinsed
R8640	T12323	T12321	conj	stained,rinsed
R8641	T12324	T12323	prep	with,stained
R8642	T12325	T12326	nummod	0.1,%
R8643	T12326	T12327	nmod	%,DOPA
R8644	T12327	T12330	nmod	DOPA,buffer
R8645	T12328	T12327	nmod	L,DOPA
R8646	T12329	T12327	punct	-,DOPA
R8647	T12330	T12324	pobj	buffer,with
R8648	T12331	T12332	punct	(,Sigma
R8649	T12332	T12327	parataxis	Sigma,DOPA
R8650	T12333	T12332	punct	", ",Sigma
R8651	T12334	T12335	compound	St.,Louis
R8652	T12335	T12332	npadvmod	Louis,Sigma
R8653	T12336	T12332	punct	", ",Sigma
R8654	T12337	T12332	npadvmod	Missouri,Sigma
R8655	T12338	T12332	punct	", ",Sigma
R8656	T12339	T12340	compound	United,States
R8657	T12340	T12332	npadvmod	States,Sigma
R8658	T12341	T12332	punct	),Sigma
R8659	T12342	T12327	punct	", ",DOPA
R8660	T12343	T12344	nummod	0.1,M
R8661	T12344	T12345	compound	M,phosphate
R8662	T12345	T12327	appos	phosphate,DOPA
R8663	T12346	T12345	compound	sodium,phosphate
R8664	T12347	T12330	punct	(,buffer
R8665	T12348	T12330	npadvmod	pH,buffer
R8666	T12349	T12348	nummod	6.8,pH
R8667	T12350	T12330	punct	),buffer
R8668	T12351	T12330	prep	for,buffer
R8669	T12352	T12353	nummod	5,h
R8670	T12353	T12351	pobj	h,for
R8671	T12354	T12330	prep	at,buffer
R8672	T12355	T12356	nummod	37,°C
R8673	T12356	T12354	pobj	°C,at
R8674	T12357	T12330	prep	in,buffer
R8675	T12358	T12359	det	the,dark
R8676	T12359	T12357	pobj	dark,in
R8677	T12360	T12323	punct	", ",stained
R8678	T12361	T12323	advcl	changing,stained
R8679	T12362	T12363	det	the,solution
R8680	T12363	T12361	dobj	solution,changing
R8681	T12364	T12363	compound	staining,solution
R8682	T12365	T12361	prep	after,changing
R8683	T12366	T12367	nummod	1,h
R8684	T12367	T12365	pobj	h,after
R8685	T12368	T12278	punct	.,split
R8686	T12370	T12371	det	The,samples
R8687	T12371	T12372	nsubjpass	samples,fixed
R8688	T12373	T12372	auxpass	were,fixed
R8689	T12374	T12372	advmod	then,fixed
R8690	T12375	T12372	advmod	overnight,fixed
R8691	T12376	T12372	punct	", ",fixed
R8692	T12377	T12372	conj	dehydrated,fixed
R8693	T12378	T12377	punct	", ",dehydrated
R8694	T12379	T12377	cc	and,dehydrated
R8695	T12380	T12377	conj	mounted,dehydrated
R8696	T12381	T12372	punct	.,fixed
R8697	T12383	T12384	det	This,method
R8698	T12384	T12385	nsubj	method,is
R8699	T12386	T12385	acomp	sufficient,is
R8700	T12387	T12388	aux	to,stain
R8701	T12388	T12386	xcomp	stain,sufficient
R8702	T12389	T12390	amod	interfollicular,melanocytes
R8703	T12390	T12388	dobj	melanocytes,stain
R8704	T12391	T12388	prep	without,stain
R8705	T12392	T12391	pcomp	creating,without
R8706	T12393	T12394	det	a,background
R8707	T12394	T12392	dobj	background,creating
R8708	T12395	T12394	amod	high,background
R8709	T12396	T12385	punct	.,is
R8710	T12398	T12399	det	The,fixative
R8711	T12399	T12400	nsubj	fixative,was
R8712	T12401	T12399	acl	used,fixative
R8713	T12402	T12400	advmod	always,was
R8714	T12403	T12404	nummod	4,%
R8715	T12404	T12405	compound	%,paraformaldehyde
R8716	T12405	T12400	attr	paraformaldehyde,was
R8717	T12406	T12400	punct	.,was
R8718	T12538	T12539	amod	Positional,cloning
R8719	T12541	T12542	det	A,map
R8720	T12542	T12546	nsubjpass	map,generated
R8721	T12543	T12544	amod	high,resolution
R8722	T12544	T12542	compound	resolution,map
R8723	T12545	T12544	punct	-,resolution
R8724	T12547	T12542	prep	for,map
R8725	T12548	T12547	pobj	deH,for
R8726	T12549	T12546	auxpass	was,generated
R8727	T12550	T12546	prep	from,generated
R8728	T12551	T12552	det	an,intercross
R8729	T12552	T12550	pobj	intercross,from
R8730	T12553	T12552	amod	intersubspecific,intercross
R8731	T12554	T12552	prep	between,intercross
R8732	T12555	T12556	nmod	deH,deH
R8733	T12556	T12558	nmod	deH,mice
R8734	T12557	T12556	punct	/,deH
R8735	T12558	T12554	pobj	mice,between
R8736	T12559	T12556	cc	and,deH
R8737	T12560	T12561	compound	CAST,Ei
R8738	T12561	T12556	conj	Ei,deH
R8739	T12562	T12561	punct	/,Ei
R8740	T12563	T12546	punct	.,generated
R8741	T12565	T12566	nsubj	We,localized
R8742	T12567	T12566	advmod	initially,localized
R8743	T12568	T12566	dobj	deH,localized
R8744	T12569	T12566	prep	to,localized
R8745	T12570	T12571	det	a,interval
R8746	T12571	T12569	pobj	interval,to
R8747	T12572	T12573	nummod	1,cM
R8748	T12573	T12571	compound	cM,interval
R8749	T12574	T12571	prep	between,interval
R8750	T12575	T12574	pobj	D3Mit233,between
R8751	T12576	T12575	cc	and,D3Mit233
R8752	T12577	T12575	conj	D3Mit11,D3Mit233
R8753	T12578	T12566	punct	.,localized
R8754	T12580	T12581	compound	F2,animals
R8755	T12581	T12582	nsubjpass	animals,tested
R8756	T12583	T12581	acl	carrying,animals
R8757	T12584	T12585	amod	recombinant,chromosomes
R8758	T12585	T12583	dobj	chromosomes,carrying
R8759	T12586	T12585	prep	between,chromosomes
R8760	T12587	T12588	det	these,markers
R8761	T12588	T12586	pobj	markers,between
R8762	T12589	T12590	poss	whose,genotype
R8763	T12590	T12591	dep	genotype,was
R8764	T12591	T12581	relcl	was,animals
R8765	T12592	T12591	prep	at,was
R8766	T12593	T12592	pobj	de,at
R8767	T12594	T12591	acomp	indeterminate,was
R8768	T12595	T12596	punct	(,deH
R8769	T12596	T12591	parataxis	deH,was
R8770	T12597	T12596	punct	/,deH
R8771	T12598	T12596	punct	+,deH
R8772	T12599	T12596	cc	or,deH
R8773	T12600	T12601	punct	+,+
R8774	T12601	T12596	conj	+,deH
R8775	T12602	T12601	punct	/,+
R8776	T12603	T12596	punct	),deH
R8777	T12604	T12582	auxpass	were,tested
R8778	T12605	T12582	dep	progeny,tested
R8779	T12606	T12582	punct	-,tested
R8780	T12607	T12582	prep	by,tested
R8781	T12608	T12607	pcomp	crossing,by
R8782	T12609	T12608	prep	to,crossing
R8783	T12610	T12611	compound	deH,deH
R8784	T12611	T12613	compound	deH,animals
R8785	T12612	T12611	punct	/,deH
R8786	T12613	T12609	pobj	animals,to
R8787	T12614	T12582	punct	.,tested
R8788	T12616	T12617	amod	Further,mapping
R8789	T12617	T12619	nsubj	mapping,established
R8790	T12618	T12617	amod	genetic,mapping
R8791	T12619	T12620	ccomp	established,used
R8792	T12621	T12622	det	a,region
R8793	T12622	T12619	dobj	region,established
R8794	T12623	T12622	amod	minimal,region
R8795	T12624	T12622	prep	of,region
R8796	T12625	T12626	nummod	0.1,cM
R8797	T12626	T12624	pobj	cM,of
R8798	T12627	T12622	prep	between,region
R8799	T12628	T12627	pobj	D3Mit213,between
R8800	T12629	T12628	cc	and,D3Mit213
R8801	T12630	T12628	conj	16.MMHAP32FLF1,D3Mit213
R8802	T12631	T12620	punct	;,used
R8803	T12632	T12633	det	these,markers
R8804	T12633	T12620	nsubjpass	markers,used
R8805	T12634	T12620	auxpass	were,used
R8806	T12635	T12636	aux	to,initiate
R8807	T12636	T12620	advcl	initiate,used
R8808	T12637	T12636	dobj	construction,initiate
R8809	T12638	T12637	prep	of,construction
R8810	T12639	T12640	det	a,map
R8811	T12640	T12638	pobj	map,of
R8812	T12641	T12640	amod	physical,map
R8813	T12642	T12637	prep	with,construction
R8814	T12643	T12644	nmod	BAC,clones
R8815	T12644	T12642	pobj	clones,with
R8816	T12645	T12644	amod	genomic,clones
R8817	T12646	T12647	punct	(,Genetics
R8818	T12647	T12636	parataxis	Genetics,initiate
R8819	T12648	T12647	compound	Research,Genetics
R8820	T12649	T12647	punct	", ",Genetics
R8821	T12650	T12647	npadvmod	Huntsville,Genetics
R8822	T12651	T12647	punct	", ",Genetics
R8823	T12652	T12647	npadvmod	Alabama,Genetics
R8824	T12653	T12647	punct	", ",Genetics
R8825	T12654	T12655	compound	United,States
R8826	T12655	T12647	npadvmod	States,Genetics
R8827	T12656	T12647	punct	", ",Genetics
R8828	T12657	T12647	cc	and,Genetics
R8829	T12658	T12659	compound	Genome,Systems
R8830	T12659	T12647	conj	Systems,Genetics
R8831	T12660	T12659	punct	", ",Systems
R8832	T12661	T12662	compound	St.,Louis
R8833	T12662	T12659	npadvmod	Louis,Systems
R8834	T12663	T12659	punct	", ",Systems
R8835	T12664	T12659	npadvmod	Missouri,Systems
R8836	T12665	T12659	punct	", ",Systems
R8837	T12666	T12667	compound	United,States
R8838	T12667	T12659	npadvmod	States,Systems
R8839	T12668	T12647	punct	),Genetics
R8840	T12669	T12620	punct	.,used
R8841	T12671	T12672	compound	End,sequence
R8842	T12672	T12673	nsubjpass	sequence,used
R8843	T12674	T12672	prep	from,sequence
R8844	T12675	T12676	det	those,BACs
R8845	T12676	T12674	pobj	BACs,from
R8846	T12677	T12673	auxpass	was,used
R8847	T12678	T12679	aux	to,develop
R8848	T12679	T12673	advcl	develop,used
R8849	T12680	T12681	compound	SSCP,markers
R8850	T12681	T12679	dobj	markers,develop
R8851	T12682	T12681	appos	M1,markers
R8852	T12683	T12682	prep	to,M1
R8853	T12684	T12683	pobj	M3,to
R8854	T12685	T12679	punct	", ",develop
R8855	T12686	T12687	mark	as,depicted
R8856	T12687	T12679	advcl	depicted,develop
R8857	T12688	T12687	prep	in,depicted
R8858	T12689	T12688	pobj	Figure,in
R8859	T12690	T12689	nummod	3,Figure
R8860	T12691	T12679	punct	", ",develop
R8861	T12692	T12679	cc	and,develop
R8862	T12693	T12694	aux	to,establish
R8863	T12694	T12679	conj	establish,develop
R8864	T12695	T12696	det	a,interval
R8865	T12696	T12694	dobj	interval,establish
R8866	T12697	T12696	amod	minimal,interval
R8867	T12698	T12696	amod	physical,interval
R8868	T12699	T12696	prep	of,interval
R8869	T12700	T12701	nummod	1.4,Mb
R8870	T12701	T12699	pobj	Mb,of
R8871	T12702	T12673	punct	.,used
R8872	T12704	T12705	compound	Primer,pairs
R8873	T12705	T12706	nsubj	pairs,were
R8874	T12707	T12705	acl	used,pairs
R8875	T12708	T12706	attr	TTCCCTCCAATAAGTTCTGGGTACC,were
R8876	T12709	T12708	cc	and,TTCCCTCCAATAAGTTCTGGGTACC
R8877	T12710	T12708	conj	AAGCTTGCTGCTCTGGATTCCATTTGTAG,TTCCCTCCAATAAGTTCTGGGTACC
R8878	T12711	T12708	prep	for,TTCCCTCCAATAAGTTCTGGGTACC
R8879	T12712	T12711	pobj	M1,for
R8880	T12713	T12708	punct	", ",TTCCCTCCAATAAGTTCTGGGTACC
R8881	T12714	T12708	conj	CCTTCATTTTTTTTTCAAGTAAAA,TTCCCTCCAATAAGTTCTGGGTACC
R8882	T12715	T12714	cc	and,CCTTCATTTTTTTTTCAAGTAAAA
R8883	T12716	T12714	conj	AAGCTTGGCTTAGTCCCAGTGGC,CCTTCATTTTTTTTTCAAGTAAAA
R8884	T12717	T12714	prep	for,CCTTCATTTTTTTTTCAAGTAAAA
R8885	T12718	T12717	pobj	M2,for
R8886	T12719	T12714	punct	", ",CCTTCATTTTTTTTTCAAGTAAAA
R8887	T12720	T12714	conj	CCTCCAGGAAGATCTACTAGGCAC,CCTTCATTTTTTTTTCAAGTAAAA
R8888	T12721	T12720	cc	and,CCTCCAGGAAGATCTACTAGGCAC
R8889	T12722	T12720	conj	ATGGAAAAAAAAAAGTAAGATTGAAAG,CCTCCAGGAAGATCTACTAGGCAC
R8890	T12723	T12720	prep	for,CCTCCAGGAAGATCTACTAGGCAC
R8891	T12724	T12723	pobj	M3,for
R8892	T12725	T12720	punct	", ",CCTCCAGGAAGATCTACTAGGCAC
R8893	T12726	T12720	cc	and,CCTCCAGGAAGATCTACTAGGCAC
R8894	T12727	T12720	conj	TGGTTATCGATCTGTGGACCATTC,CCTCCAGGAAGATCTACTAGGCAC
R8895	T12728	T12727	cc	and,TGGTTATCGATCTGTGGACCATTC
R8896	T12729	T12727	conj	AAGTGAGAGAGCAGGATGGACCAC,TGGTTATCGATCTGTGGACCATTC
R8897	T12730	T12727	prep	for,TGGTTATCGATCTGTGGACCATTC
R8898	T12731	T12730	pobj	M4,for
R8899	T12732	T12733	punct	(,represents
R8900	T12733	T12731	parataxis	represents,M4
R8901	T12734	T12735	det	the,marker
R8902	T12735	T12733	nsubj	marker,represents
R8903	T12736	T12735	compound	M4,marker
R8904	T12737	T12738	compound	STS,16.MMHAP32FLF1
R8905	T12738	T12733	dobj	16.MMHAP32FLF1,represents
R8906	T12739	T12733	punct	),represents
R8907	T12740	T12706	punct	.,were
R8908	T12742	T12743	amod	Genomic,sequence
R8909	T12743	T12744	nsubjpass	sequence,obtained
R8910	T12744	T12748	ccomp	obtained,contains
R8911	T12745	T12743	cc	and,sequence
R8912	T12746	T12743	conj	annotations,sequence
R8913	T12747	T12744	auxpass	were,obtained
R8914	T12749	T12744	prep	from,obtained
R8915	T12750	T12751	det	the,Browser
R8916	T12751	T12754	nmod	Browser,mm3
R8917	T12752	T12751	nmod	UCSC,Browser
R8918	T12753	T12751	nmod	Genome,Browser
R8919	T12754	T12749	pobj	mm3,from
R8920	T12755	T12756	nmod	February,assembly
R8921	T12756	T12754	compound	assembly,mm3
R8922	T12757	T12755	nummod	2003,February
R8923	T12758	T12754	compound	version,mm3
R8924	T12759	T12760	punct	(,http://genome.ucsc.edu
R8925	T12760	T12754	parataxis	http://genome.ucsc.edu,mm3
R8926	T12761	T12760	punct	),http://genome.ucsc.edu
R8927	T12762	T12748	punct	;,contains
R8928	T12763	T12764	det	the,interval
R8929	T12764	T12748	nsubj	interval,contains
R8930	T12765	T12766	nummod	1.4,Mb
R8931	T12766	T12764	compound	Mb,interval
R8932	T12767	T12764	prep	between,interval
R8933	T12768	T12767	pobj	M1,between
R8934	T12769	T12768	cc	and,M1
R8935	T12770	T12768	conj	M4,M1
R8936	T12771	T12772	nummod	eight,genes
R8937	T12772	T12748	dobj	genes,contains
R8938	T12773	T12772	punct	: ,genes
R8939	T12774	T12775	nummod	four,isomerases
R8940	T12775	T12772	appos	isomerases,genes
R8941	T12776	T12775	compound	hydroxysteroid,isomerases
R8942	T12777	T12775	compound	dehydrogenase,isomerases
R8943	T12778	T12775	punct	", ",isomerases
R8944	T12779	T12775	appos	Hsd3b3,isomerases
R8945	T12780	T12779	punct	", ",Hsd3b3
R8946	T12781	T12779	conj	Hsd3b2,Hsd3b3
R8947	T12782	T12781	punct	", ",Hsd3b2
R8948	T12783	T12781	conj	Hsd3b6,Hsd3b2
R8949	T12784	T12783	punct	", ",Hsd3b6
R8950	T12785	T12783	cc	and,Hsd3b6
R8951	T12786	T12783	conj	Hsd3b1,Hsd3b6
R8952	T12787	T12775	punct	;,isomerases
R8953	T12788	T12789	det	an,oxidase
R8954	T12789	T12775	conj	oxidase,isomerases
R8955	T12790	T12789	compound	hydroacid,oxidase
R8956	T12791	T12789	punct	", ",oxidase
R8957	T12792	T12789	appos	Hao3,oxidase
R8958	T12793	T12789	punct	;,oxidase
R8959	T12794	T12795	det	a,synthetase
R8960	T12795	T12789	conj	synthetase,oxidase
R8961	T12796	T12797	compound	tryptophanyl,tRNA
R8962	T12797	T12795	compound	tRNA,synthetase
R8963	T12798	T12797	punct	-,tRNA
R8964	T12799	T12795	punct	", ",synthetase
R8965	T12800	T12795	appos	Wars2,synthetase
R8966	T12801	T12795	punct	;,synthetase
R8967	T12802	T12803	det	a,gene
R8968	T12803	T12795	conj	gene,synthetase
R8969	T12804	T12805	compound	T,box
R8970	T12805	T12803	compound	box,gene
R8971	T12806	T12805	punct	-,box
R8972	T12807	T12803	punct	", ",gene
R8973	T12808	T12803	appos	Tbx15,gene
R8974	T12809	T12803	punct	;,gene
R8975	T12810	T12803	cc	and,gene
R8976	T12811	T12812	det	a,gene
R8977	T12812	T12803	conj	gene,gene
R8978	T12813	T12812	amod	novel,gene
R8979	T12814	T12812	punct	", ",gene
R8980	T12815	T12812	appos	4931427F14Rik,gene
R8981	T12816	T12748	punct	.,contains
R8982	T12818	T12819	prep	In,correspond
R8983	T12820	T12821	det	the,sequence
R8984	T12821	T12818	pobj	sequence,In
R8985	T12822	T12821	compound	genome,sequence
R8986	T12823	T12819	punct	", ",correspond
R8987	T12824	T12825	compound	M1,primers
R8988	T12825	T12819	nsubj	primers,correspond
R8989	T12826	T12819	prep	to,correspond
R8990	T12827	T12826	pobj	AGGCCTCCAATAAGTTCTGGGTACC,to
R8991	T12828	T12827	cc	and,AGGCCTCCAATAAGTTCTGGGTACC
R8992	T12829	T12827	conj	AAGCTTGCTCTCTGGATTCCATTTGTAG,AGGCCTCCAATAAGTTCTGGGTACC
R8993	T12830	T12819	punct	", ",correspond
R8994	T12831	T12832	det	the,primer
R8995	T12832	T12835	nsubj	primer,corresponds
R8996	T12833	T12832	nmod	M2,primer
R8997	T12834	T12832	amod	reverse,primer
R8998	T12835	T12819	conj	corresponds,correspond
R8999	T12836	T12835	prep	to,corresponds
R9000	T12837	T12836	pobj	AAGCTTGGCTTTAGTCCCAGTGGGC,to
R9001	T12838	T12835	punct	", ",corresponds
R9002	T12839	T12835	cc	and,corresponds
R9003	T12840	T12841	det	the,primers
R9004	T12841	T12843	nsubj	primers,correspond
R9005	T12842	T12841	compound	M3,primers
R9006	T12843	T12835	conj	correspond,corresponds
R9007	T12844	T12843	prep	to,correspond
R9008	T12845	T12844	pobj	CCTCCAGGAAGAATCTACTAGGCAC,to
R9009	T12846	T12845	cc	and,CCTCCAGGAAGAATCTACTAGGCAC
R9010	T12847	T12845	conj	AATGAAAAAAAAAAAAGTAAGATTGAAAG,CCTCCAGGAAGAATCTACTAGGCAC
R9011	T12848	T12819	punct	.,correspond
R9012	T12850	T12851	amod	Minor,differences
R9013	T12851	T12852	nsubj	differences,represent
R9014	T12853	T12851	prep	among,differences
R9015	T12854	T12855	det	the,sequences
R9016	T12855	T12853	pobj	sequences,among
R9017	T12856	T12855	prep	of,sequences
R9018	T12857	T12858	det	the,primers
R9019	T12858	T12856	pobj	primers,of
R9020	T12859	T12860	nsubj	we,obtained
R9021	T12860	T12858	advcl	obtained,primers
R9022	T12861	T12860	prep	from,obtained
R9023	T12862	T12863	det	the,BAC
R9024	T12863	T12861	pobj	BAC,from
R9025	T12864	T12863	nmod	ends,BAC
R9026	T12865	T12855	cc	and,sequences
R9027	T12866	T12867	det	the,sequence
R9028	T12867	T12855	conj	sequence,sequences
R9029	T12868	T12867	amod	public,sequence
R9030	T12869	T12867	compound	genome,sequence
R9031	T12870	T12852	aux	may,represent
R9032	T12871	T12872	compound	strain,differences
R9033	T12872	T12852	dobj	differences,represent
R9034	T12873	T12872	cc	or,differences
R9035	T12874	T12875	compound	sequencing,errors
R9036	T12875	T12872	conj	errors,differences
R9037	T12876	T12875	prep	on,errors
R9038	T12877	T12878	det	the,DNA
R9039	T12878	T12876	pobj	DNA,on
R9040	T12879	T12878	compound	BAC,DNA
R9041	T12880	T12852	punct	.,represent
R9042	T12882	T12883	det	A,assay
R9043	T12883	T12886	nsubjpass	assay,developed
R9044	T12884	T12883	amod	multiplex,assay
R9045	T12885	T12883	amod	genotyping,assay
R9046	T12887	T12886	auxpass	was,developed
R9047	T12888	T12889	aux	to,genotype
R9048	T12889	T12886	advcl	genotype,developed
R9049	T12890	T12889	prep	for,genotype
R9050	T12891	T12892	det	the,deletion
R9051	T12892	T12890	pobj	deletion,for
R9052	T12893	T12892	compound	deH,deletion
R9053	T12894	T12889	advcl	using,genotype
R9054	T12895	T12896	compound	primers,GGAGCAGATCCAATTGCTTT
R9055	T12896	T12894	dobj	GGAGCAGATCCAATTGCTTT,using
R9056	T12897	T12896	punct	", ",GGAGCAGATCCAATTGCTTT
R9057	T12898	T12896	conj	TCCATAGCCCATCTTCACAA,GGAGCAGATCCAATTGCTTT
R9058	T12899	T12898	punct	", ",TCCATAGCCCATCTTCACAA
R9059	T12900	T12898	cc	and,TCCATAGCCCATCTTCACAA
R9060	T12901	T12898	conj	CATGTCCACTTCTGCTTCCA,TCCATAGCCCATCTTCACAA
R9061	T12902	T12886	punct	.,developed
R9062	T12904	T12905	det	This,assay
R9063	T12905	T12907	nsubj	assay,produces
R9064	T12906	T12905	compound	PCR,assay
R9065	T12908	T12909	det	a,product
R9066	T12909	T12907	dobj	product,produces
R9067	T12910	T12911	nummod	392,bp
R9068	T12911	T12909	compound	bp,product
R9069	T12912	T12907	prep	from,produces
R9070	T12913	T12914	det	the,chromosome
R9071	T12914	T12912	pobj	chromosome,from
R9072	T12915	T12914	compound	deH,chromosome
R9073	T12916	T12907	cc	and,produces
R9074	T12917	T12918	det	a,product
R9075	T12918	T12907	conj	product,produces
R9076	T12919	T12920	nummod	595,bp
R9077	T12920	T12918	compound	bp,product
R9078	T12921	T12918	prep	from,product
R9079	T12922	T12923	det	the,chromosome
R9080	T12923	T12921	pobj	chromosome,from
R9081	T12924	T12923	amod	nonmutant,chromosome
R9082	T12925	T12907	punct	.,produces
R9099	T12993	T12990	punct	(,Russ
R9100	T12994	T12990	npadvmod	2000,Russ
R9101	T12995	T12990	punct	),Russ
R9102	T12996	T12980	punct	.,constructed
R9103	T12998	T12999	prep	In,inserted
R9104	T13000	T12998	pobj	brief,In
R9105	T13001	T12999	punct	", ",inserted
R9106	T13002	T13003	det	an,cassette
R9107	T13003	T12999	nsubjpass	cassette,inserted
R9108	T13004	T13005	compound	IRES,neo
R9109	T13005	T13003	compound	neo,cassette
R9110	T13006	T13005	punct	-,neo
R9111	T13007	T13005	compound	LacZ,neo
R9112	T13008	T13005	punct	-,neo
R9113	T13009	T13003	prep	with,cassette
R9114	T13010	T13011	nummod	5,arms
R9115	T13011	T13009	pobj	arms,with
R9116	T13012	T13010	punct	′,5
R9117	T13013	T13010	cc	and,5
R9118	T13014	T13010	conj	3,5
R9119	T13015	T13014	punct	′,3
R9120	T13016	T13011	compound	homology,arms
R9121	T13017	T13011	prep	of,arms
R9122	T13018	T13019	nummod	3.5,kb
R9123	T13019	T13017	pobj	kb,of
R9124	T13020	T13019	cc	and,kb
R9125	T13021	T13022	nummod	1.8,kb
R9126	T13022	T13019	conj	kb,kb
R9127	T13023	T12999	auxpass	was,inserted
R9128	T13024	T12999	prep	into,inserted
R9129	T13025	T13026	det	a,site
R9130	T13026	T13024	pobj	site,into
R9131	T13027	T13026	amod	unique,site
R9132	T13028	T13026	compound	BamHI,site
R9133	T13029	T13030	dep	that,lies
R9134	T13030	T13026	relcl	lies,site
R9135	T13031	T13032	nummod	479,nucleotides
R9136	T13032	T13033	npadvmod	nucleotides,downstream
R9137	T13033	T13030	advmod	downstream,lies
R9138	T13034	T13033	prep	of,downstream
R9139	T13035	T13036	det	the,site
R9140	T13036	T13034	pobj	site,of
R9141	T13037	T13036	amod	transcriptional,site
R9142	T13038	T13036	compound	initiation,site
R9143	T13039	T13030	punct	(,lies
R9144	T13040	T13030	advcl	relative,lies
R9145	T13041	T13040	prep	to,relative
R9146	T13042	T13043	det	the,sequence
R9147	T13043	T13041	pobj	sequence,to
R9148	T13044	T13043	compound	mRNA,sequence
R9149	T13045	T13030	punct	),lies
R9150	T13046	T13030	prep	in,lies
R9151	T13047	T13046	pobj	exon,in
R9152	T13048	T13047	nummod	3,exon
R9153	T13049	T12999	punct	.,inserted
R9154	T13051	T13052	amod	Positive,clones
R9155	T13052	T13054	nsubjpass	clones,injected
R9156	T13053	T13052	compound	ES,clones
R9157	T13055	T13054	auxpass	were,injected
R9158	T13056	T13054	prep	into,injected
R9159	T13057	T13058	compound	B6,blastocysts
R9160	T13058	T13056	pobj	blastocysts,into
R9161	T13059	T13054	punct	", ",injected
R9162	T13060	T13054	cc	and,injected
R9163	T13061	T13062	amod	chimeric,founders
R9164	T13062	T13063	nsubj	founders,crossed
R9165	T13063	T13054	conj	crossed,injected
R9166	T13064	T13063	prep	to,crossed
R9167	T13065	T13066	preconj	either,mice
R9168	T13066	T13064	pobj	mice,to
R9169	T13067	T13066	compound	B6,mice
R9170	T13068	T13064	cc	or,to
R9171	T13069	T13064	conj	to,to
R9172	T13070	T13071	nmod	deH,animals
R9173	T13071	T13069	pobj	animals,to
R9174	T13072	T13070	punct	/,deH
R9175	T13073	T13070	punct	+,deH
R9176	T13074	T13063	punct	.,crossed
R9177	T13131	T13132	advmod	In,situ
R9178	T13132	T13133	amod	situ,hybridization
R9179	T13135	T13136	advmod	In,situ
R9180	T13136	T13137	amod	situ,hybridization
R9181	T13137	T13138	nsubjpass	hybridization,carried
R9182	T13139	T13138	auxpass	was,carried
R9183	T13140	T13138	prt	out,carried
R9184	T13141	T13138	prep	on,carried
R9185	T13142	T13143	nummod	12,μm
R9186	T13143	T13145	compound	μm,sections
R9187	T13144	T13143	punct	-,μm
R9188	T13145	T13141	pobj	sections,on
R9189	T13146	T13145	compound	paraffin,sections
R9190	T13147	T13138	advcl	using,carried
R9191	T13148	T13149	npadvmod	digoxigenin,labeled
R9192	T13149	T13151	amod	labeled,probes
R9193	T13150	T13149	punct	-,labeled
R9194	T13151	T13147	dobj	probes,using
R9195	T13152	T13151	compound	RNA,probes
R9196	T13153	T13154	punct	(,Diagnostics
R9197	T13154	T13151	parataxis	Diagnostics,probes
R9198	T13155	T13154	compound	Roche,Diagnostics
R9199	T13156	T13154	punct	", ",Diagnostics
R9200	T13157	T13154	npadvmod	Indianapolis,Diagnostics
R9201	T13158	T13154	punct	", ",Diagnostics
R9202	T13159	T13154	npadvmod	Indiana,Diagnostics
R9203	T13160	T13154	punct	", ",Diagnostics
R9204	T13161	T13162	compound	United,States
R9205	T13162	T13154	npadvmod	States,Diagnostics
R9206	T13163	T13154	punct	),Diagnostics
R9207	T13164	T13147	prep	according,using
R9208	T13165	T13164	prep	to,according
R9209	T13166	T13167	amod	standard,protocols
R9210	T13167	T13165	pobj	protocols,to
R9211	T13168	T13169	punct	(,Wilkinson
R9212	T13169	T13167	meta	Wilkinson,protocols
R9213	T13170	T13169	cc	and,Wilkinson
R9214	T13171	T13169	conj	Nieto,Wilkinson
R9215	T13172	T13171	nummod	1993,Nieto
R9216	T13173	T13171	punct	),Nieto
R9217	T13174	T13138	punct	.,carried
R9218	T13176	T13177	nsubjpass	Embryos,obtained
R9219	T13178	T13176	cc	and,Embryos
R9220	T13179	T13180	amod	postnatal,samples
R9221	T13180	T13176	conj	samples,Embryos
R9222	T13181	T13180	compound	skin,samples
R9223	T13182	T13177	auxpass	were,obtained
R9224	T13183	T13177	prep	from,obtained
R9225	T13184	T13183	pobj	intercrosses,from
R9226	T13185	T13184	prep	of,intercrosses
R9227	T13186	T13187	nmod	deH,mice
R9228	T13187	T13185	pobj	mice,of
R9229	T13188	T13186	punct	/,deH
R9230	T13189	T13186	punct	+,deH
R9231	T13190	T13177	punct	.,obtained
R9232	T13192	T13193	nsubjpass	Embryos,fixed
R9233	T13193	T13198	ccomp	fixed,fixed
R9234	T13194	T13192	npadvmod	E13.5,Embryos
R9235	T13195	T13194	cc	or,E13.5
R9236	T13196	T13194	conj	younger,E13.5
R9237	T13197	T13193	auxpass	were,fixed
R9238	T13199	T13193	prep	for,fixed
R9239	T13200	T13201	nummod	24,h
R9240	T13201	T13199	pobj	h,for
R9241	T13202	T13198	punct	;,fixed
R9242	T13203	T13198	nsubjpass	those,fixed
R9243	T13204	T13203	amod	older,those
R9244	T13205	T13204	prep	than,older
R9245	T13206	T13205	pobj	E13.5,than
R9246	T13207	T13203	cc	and,those
R9247	T13208	T13209	amod	postnatal,skin
R9248	T13209	T13203	conj	skin,those
R9249	T13210	T13198	auxpass	were,fixed
R9250	T13211	T13198	prep	for,fixed
R9251	T13212	T13213	quantmod	36,48
R9252	T13213	T13215	nummod	48,h
R9253	T13214	T13213	punct	–,48
R9254	T13215	T13211	pobj	h,for
R9255	T13216	T13198	advmod	prior,fixed
R9256	T13217	T13216	prep	to,prior
R9257	T13218	T13217	pobj	embedding,to
R9258	T13219	T13198	punct	.,fixed
R9259	T13221	T13222	det	The,probe
R9260	T13222	T13224	nsubjpass	probe,generated
R9261	T13223	T13222	compound	Tbx15,probe
R9262	T13225	T13224	auxpass	was,generated
R9263	T13226	T13224	prep	by,generated
R9264	T13227	T13228	compound	RT,PCR
R9265	T13228	T13226	pobj	PCR,by
R9266	T13229	T13228	punct	–,PCR
R9267	T13230	T13224	advcl	using,generated
R9268	T13231	T13232	compound	primers,GGCGGCTAAAATGAGTGAAC
R9269	T13232	T13230	dobj	GGCGGCTAAAATGAGTGAAC,using
R9270	T13233	T13232	cc	and,GGCGGCTAAAATGAGTGAAC
R9271	T13234	T13232	conj	TGCCTGCTTTGGTGATGAT,GGCGGCTAAAATGAGTGAAC
R9272	T13235	T13236	punct	(,corresponds
R9273	T13236	T13230	parataxis	corresponds,using
R9274	T13237	T13236	prep	to,corresponds
R9275	T13238	T13237	pobj	exons,to
R9276	T13239	T13238	nummod	1,exons
R9277	T13240	T13238	cc	and,exons
R9278	T13241	T13238	conj	2,exons
R9279	T13242	T13236	punct	),corresponds
R9280	T13243	T13224	punct	", ",generated
R9281	T13244	T13224	cc	and,generated
R9282	T13245	T13246	det	the,probe
R9283	T13246	T13248	nsubjpass	probe,generated
R9284	T13247	T13246	compound	En1,probe
R9285	T13248	T13224	conj	generated,generated
R9286	T13249	T13248	auxpass	was,generated
R9287	T13250	T13248	prep	by,generated
R9288	T13251	T13250	pobj	PCR,by
R9289	T13252	T13248	prep	from,generated
R9290	T13253	T13254	amod	genomic,DNA
R9291	T13254	T13252	pobj	DNA,from
R9292	T13255	T13248	advcl	using,generated
R9293	T13256	T13257	compound	primers,ACGCACCAGGAAGCTAAAGA
R9294	T13257	T13255	dobj	ACGCACCAGGAAGCTAAAGA,using
R9295	T13258	T13257	cc	and,ACGCACCAGGAAGCTAAAGA
R9296	T13259	T13257	conj	AGCAACGAAAACGAAACTGG,ACGCACCAGGAAGCTAAAGA
R9297	T13260	T13261	punct	(,located
R9298	T13261	T13255	parataxis	located,using
R9299	T13262	T13261	prep	in,located
R9300	T13263	T13264	det	the,exon
R9301	T13264	T13262	pobj	exon,in
R9302	T13265	T13264	amod	last,exon
R9303	T13266	T13261	punct	),located
R9304	T13267	T13248	punct	.,generated
R9305	T13269	T13270	det	The,probe
R9306	T13270	T13272	nsubj	probe,corresponds
R9307	T13271	T13270	compound	Agouti,probe
R9308	T13273	T13272	prep	to,corresponds
R9309	T13274	T13275	det	the,sequence
R9310	T13275	T13273	pobj	sequence,to
R9311	T13276	T13277	npadvmod	protein,coding
R9312	T13277	T13275	amod	coding,sequence
R9313	T13278	T13277	punct	-,coding
R9314	T13279	T13272	punct	.,corresponds
R9315	T13332	T13333	amod	Embryonic,transplantation
R9316	T13334	T13333	compound	skin,transplantation
R9317	T13336	T13337	punct	(,dissected
R9318	T13338	T13339	nmod	BTBR,embryos
R9319	T13339	T13337	nsubjpass	embryos,dissected
R9320	T13340	T13338	punct	-,BTBR
R9321	T13341	T13342	compound	at,at
R9322	T13342	T13338	appos	at,BTBR
R9323	T13343	T13342	punct	/,at
R9324	T13344	T13338	punct	×,BTBR
R9325	T13345	T13338	appos	B6,BTBR
R9326	T13346	T13345	punct	-,B6
R9327	T13347	T13348	compound	a,a
R9328	T13348	T13345	appos	a,B6
R9329	T13349	T13348	punct	/,a
R9330	T13350	T13339	punct	),embryos
R9331	T13351	T13339	compound	F1,embryos
R9332	T13352	T13339	prep	at,embryos
R9333	T13353	T13352	pobj	E12.5,at
R9334	T13354	T13337	auxpass	were,dissected
R9335	T13355	T13337	prep	in,dissected
R9336	T13356	T13357	amod	sterile,solution
R9337	T13357	T13355	pobj	solution,in
R9338	T13358	T13357	poss	Tyrode,solution
R9339	T13359	T13358	case	's,Tyrode
R9340	T13360	T13337	punct	", ",dissected
R9341	T13361	T13337	cc	and,dissected
R9342	T13362	T13363	amod	embryonic,skin
R9343	T13363	T13364	nsubjpass	skin,divided
R9344	T13364	T13337	conj	divided,dissected
R9345	T13365	T13364	auxpass	was,divided
R9346	T13366	T13364	prep	into,divided
R9347	T13367	T13368	amod	dorsal,pieces
R9348	T13368	T13366	pobj	pieces,into
R9349	T13369	T13367	punct	", ",dorsal
R9350	T13370	T13367	conj	flank,dorsal
R9351	T13371	T13370	punct	", ",flank
R9352	T13372	T13370	cc	and,flank
R9353	T13373	T13370	conj	ventral,flank
R9354	T13374	T13368	punct	", ",pieces
R9355	T13375	T13376	advmod	each,mm2
R9356	T13376	T13368	appos	mm2,pieces
R9357	T13377	T13378	compound	1,2
R9358	T13378	T13376	nummod	2,mm2
R9359	T13379	T13378	punct	–,2
R9360	T13380	T13376	prep	in,mm2
R9361	T13381	T13380	pobj	size,in
R9362	T13382	T13364	punct	", ",divided
R9363	T13383	T13384	mark	as,shown
R9364	T13384	T13364	advcl	shown,divided
R9365	T13385	T13384	prep	in,shown
R9366	T13386	T13385	pobj	Figure,in
R9367	T13387	T13386	nummod	7,Figure
R9368	T13388	T13364	punct	.,divided
R9369	T13390	T13391	compound	Skin,fragments
R9370	T13391	T13392	nsubjpass	fragments,grafted
R9371	T13393	T13392	auxpass	were,grafted
R9372	T13394	T13392	prep	to,grafted
R9373	T13395	T13396	det	the,testes
R9374	T13396	T13394	pobj	testes,to
R9375	T13397	T13396	prep	of,testes
R9376	T13398	T13399	amod	congenic,animals
R9377	T13399	T13397	pobj	animals,of
R9378	T13400	T13401	mark	as,follows
R9379	T13401	T13392	advcl	follows,grafted
R9380	T13402	T13392	punct	.,grafted
R9381	T13404	T13405	prep	After,made
R9382	T13406	T13404	pobj	anesthetization,After
R9383	T13407	T13406	prep	with,anesthetization
R9384	T13408	T13409	nummod	2.5,%
R9385	T13409	T13410	compound	%,Avertin
R9386	T13410	T13407	pobj	Avertin,with
R9387	T13411	T13405	punct	", ",made
R9388	T13412	T13413	det	a,incision
R9389	T13413	T13405	nsubjpass	incision,made
R9390	T13414	T13415	nummod	1.5,cm
R9391	T13415	T13413	compound	cm,incision
R9392	T13416	T13415	punct	-,cm
R9393	T13417	T13413	prep	in,incision
R9394	T13418	T13419	det	the,skin
R9395	T13419	T13417	pobj	skin,in
R9396	T13420	T13419	cc	and,skin
R9397	T13421	T13422	compound	body,wall
R9398	T13422	T13419	conj	wall,skin
R9399	T13423	T13405	auxpass	was,made
R9400	T13424	T13405	prep	at,made
R9401	T13425	T13426	det	a,point
R9402	T13426	T13424	pobj	point,at
R9403	T13427	T13426	amod	level,point
R9404	T13428	T13427	prep	with,level
R9405	T13429	T13430	det	the,top
R9406	T13430	T13428	pobj	top,with
R9407	T13431	T13430	prep	of,top
R9408	T13432	T13433	det	the,limbs
R9409	T13433	T13431	pobj	limbs,of
R9410	T13434	T13405	punct	.,made
R9411	T13436	T13437	det	The,pads
R9412	T13437	T13439	nsubjpass	pads,pulled
R9413	T13438	T13437	compound	fat,pads
R9414	T13440	T13439	auxpass	were,pulled
R9415	T13441	T13439	prt	out,pulled
R9416	T13442	T13439	cc	and,pulled
R9417	T13443	T13439	conj	laid,pulled
R9418	T13444	T13443	prep	on,laid
R9419	T13445	T13446	det	the,outside
R9420	T13446	T13444	pobj	outside,on
R9421	T13447	T13446	prep	of,outside
R9422	T13448	T13449	det	the,body
R9423	T13449	T13447	pobj	body,of
R9424	T13450	T13443	punct	", ",laid
R9425	T13451	T13443	advcl	exposing,laid
R9426	T13452	T13453	det	the,testes
R9427	T13453	T13451	dobj	testes,exposing
R9428	T13454	T13439	punct	.,pulled
R9429	T13456	T13457	nsubjpass	Forceps,used
R9430	T13458	T13457	auxpass	were,used
R9431	T13459	T13460	aux	to,introduce
R9432	T13460	T13457	advcl	introduce,used
R9433	T13461	T13462	det	a,hole
R9434	T13462	T13460	dobj	hole,introduce
R9435	T13463	T13462	amod	small,hole
R9436	T13464	T13462	prep	in,hole
R9437	T13465	T13466	det	the,capsule
R9438	T13466	T13464	pobj	capsule,in
R9439	T13467	T13466	compound	testis,capsule
R9440	T13468	T13469	prep	through,inserted
R9441	T13469	T13462	relcl	inserted,hole
R9442	T13470	T13468	pobj	which,through
R9443	T13471	T13472	det	a,piece
R9444	T13472	T13469	nsubjpass	piece,inserted
R9445	T13473	T13472	prep	of,piece
R9446	T13474	T13475	amod	dissected,skin
R9447	T13475	T13473	pobj	skin,of
R9448	T13476	T13475	amod	embryonic,skin
R9449	T13477	T13469	auxpass	was,inserted
R9450	T13478	T13457	punct	", ",used
R9451	T13479	T13480	det	the,testes
R9452	T13480	T13481	nsubjpass	testes,replaced
R9453	T13481	T13457	conj	replaced,used
R9454	T13482	T13481	auxpass	were,replaced
R9455	T13483	T13481	advmod	then,replaced
R9456	T13484	T13481	prep	into,replaced
R9457	T13485	T13486	det	the,cavity
R9458	T13486	T13484	pobj	cavity,into
R9459	T13487	T13486	amod	abdominal,cavity
R9460	T13488	T13481	punct	", ",replaced
R9461	T13489	T13481	cc	and,replaced
R9462	T13490	T13491	det	the,wound
R9463	T13491	T13492	nsubjpass	wound,closed
R9464	T13492	T13481	conj	closed,replaced
R9465	T13493	T13492	auxpass	was,closed
R9466	T13494	T13492	prep	in,closed
R9467	T13495	T13496	preconj	both,wall
R9468	T13496	T13494	pobj	wall,in
R9469	T13497	T13496	det	the,wall
R9470	T13498	T13496	compound	body,wall
R9471	T13499	T13496	cc	and,wall
R9472	T13500	T13501	det	the,skin
R9473	T13501	T13496	conj	skin,wall
R9474	T13502	T13492	punct	.,closed
R9475	T13504	T13505	prep	After,sacrificed
R9476	T13506	T13507	nummod	21,days
R9477	T13507	T13504	pobj	days,After
R9478	T13508	T13505	punct	", ",sacrificed
R9479	T13509	T13505	nsubjpass	mice,sacrificed
R9480	T13510	T13511	dep	that,received
R9481	T13511	T13509	relcl	received,mice
R9482	T13512	T13511	dobj	grafts,received
R9483	T13513	T13505	auxpass	were,sacrificed
R9484	T13514	T13505	cc	and,sacrificed
R9485	T13515	T13516	det	the,hair
R9486	T13516	T13518	nsubjpass	hair,dissected
R9487	T13517	T13516	amod	resulting,hair
R9488	T13518	T13505	conj	dissected,sacrificed
R9489	T13519	T13518	auxpass	was,dissected
R9490	T13520	T13518	prep	from,dissected
R9491	T13521	T13522	det	the,testes
R9492	T13522	T13520	pobj	testes,from
R9493	T13523	T13518	cc	and,dissected
R9494	T13524	T13518	conj	examined,dissected
R9495	T13525	T13505	punct	.,sacrificed
R9498	T13570	T13571	dep	Fate,mapping
R9499	T13572	T13571	punct	-,mapping
R9500	T13573	T13574	det	the,frontier
R9501	T13574	T13571	dobj	frontier,mapping
R9502	T13575	T13574	amod	lateral,frontier
R9503	T13576	T13574	amod	somitic,frontier
R9504	T13578	T13579	det	The,transgene
R9505	T13579	T13583	nsubjpass	transgene,expressed
R9506	T13580	T13581	compound	Hoxb6,Cre
R9507	T13581	T13579	compound	Cre,transgene
R9508	T13582	T13581	punct	-,Cre
R9509	T13584	T13579	acl	described,transgene
R9510	T13585	T13584	agent	by,described
R9511	T13586	T13585	pobj	Kuehn,by
R9512	T13587	T13586	cc	and,Kuehn
R9513	T13588	T13586	conj	colleagues,Kuehn
R9514	T13589	T13590	punct	(,Lowe
R9515	T13590	T13584	meta	Lowe,described
R9516	T13591	T13590	nmod	et,Lowe
R9517	T13592	T13590	nmod	al.,Lowe
R9518	T13593	T13590	nummod	2000,Lowe
R9519	T13594	T13590	punct	),Lowe
R9520	T13595	T13583	auxpass	is,expressed
R9521	T13596	T13583	prep	in,expressed
R9522	T13597	T13598	det	the,plate
R9523	T13598	T13596	pobj	plate,in
R9524	T13599	T13598	amod	lateral,plate
R9525	T13600	T13598	cc	but,plate
R9526	T13601	T13600	neg	not,but
R9527	T13602	T13603	det	the,mesoderm
R9528	T13603	T13598	conj	mesoderm,plate
R9529	T13604	T13603	amod	somitic,mesoderm
R9530	T13605	T13598	prep	of,plate
R9531	T13606	T13607	det	the,trunk
R9532	T13607	T13605	pobj	trunk,of
R9533	T13608	T13583	punct	", ",expressed
R9534	T13609	T13583	advcl	beginning,expressed
R9535	T13610	T13609	prep	at,beginning
R9536	T13611	T13610	pobj	E9.5,at
R9537	T13612	T13583	punct	.,expressed
R9538	T13614	T13615	nsubjpass	Animals,used
R9539	T13616	T13617	advmod	doubly,heterozygous
R9540	T13617	T13614	amod	heterozygous,Animals
R9541	T13618	T13617	prep	for,heterozygous
R9542	T13619	T13620	det	this,transgene
R9543	T13620	T13618	pobj	transgene,for
R9544	T13621	T13620	cc	and,transgene
R9545	T13622	T13623	det	the,gene
R9546	T13623	T13620	conj	gene,transgene
R9547	T13624	T13623	compound	R26R,gene
R9548	T13625	T13623	compound	reporter,gene
R9549	T13626	T13615	auxpass	were,used
R9550	T13627	T13615	prep	as,used
R9551	T13628	T13629	det	a,source
R9552	T13629	T13627	pobj	source,as
R9553	T13630	T13629	prep	of,source
R9554	T13631	T13632	amod	whole,skin
R9555	T13632	T13630	pobj	skin,of
R9556	T13633	T13615	prep	at,used
R9557	T13634	T13633	pobj	P1.5,at
R9558	T13635	T13634	cc	or,P1.5
R9559	T13636	T13634	conj	P4.5,P1.5
R9560	T13637	T13615	punct	.,used
R9561	T13639	T13640	compound	Skin,sections
R9562	T13640	T13641	nsubjpass	sections,prepared
R9563	T13642	T13640	amod	parallel,sections
R9564	T13643	T13642	prep	to,parallel
R9565	T13644	T13645	det	the,axis
R9566	T13645	T13643	pobj	axis,to
R9567	T13646	T13645	amod	dorsoventral,axis
R9568	T13647	T13641	auxpass	were,prepared
R9569	T13648	T13641	prep	with,prepared
R9570	T13649	T13650	det	a,incision
R9571	T13650	T13648	pobj	incision,with
R9572	T13651	T13650	amod	single,incision
R9573	T13652	T13650	prep	along,incision
R9574	T13653	T13654	det	the,midline
R9575	T13654	T13652	pobj	midline,along
R9576	T13655	T13654	amod	ventral,midline
R9577	T13656	T13641	cc	and,prepared
R9578	T13657	T13641	conj	stained,prepared
R9579	T13658	T13657	prep	for,stained
R9580	T13659	T13660	compound	β,galactosidase
R9581	T13660	T13662	compound	galactosidase,activity
R9582	T13661	T13660	punct	-,galactosidase
R9583	T13662	T13658	pobj	activity,for
R9584	T13663	T13657	advcl	using,stained
R9585	T13664	T13665	amod	standard,protocols
R9586	T13665	T13663	dobj	protocols,using
R9587	T13666	T13657	prep	at,stained
R9588	T13667	T13668	compound	room,temperature
R9589	T13668	T13666	pobj	temperature,at
R9590	T13669	T13641	punct	.,prepared
R9591	T13671	T13672	det	The,sample
R9592	T13672	T13674	nsubjpass	sample,stained
R9593	T13673	T13672	compound	P1.5,sample
R9594	T13675	T13674	auxpass	was,stained
R9595	T13676	T13674	advmod	overnight,stained
R9596	T13677	T13674	cc	and,stained
R9597	T13678	T13679	det	the,samples
R9598	T13679	T13681	nsubjpass	samples,stained
R9599	T13680	T13679	compound	P4.5,samples
R9600	T13681	T13674	conj	stained,stained
R9601	T13682	T13681	auxpass	were,stained
R9602	T13683	T13681	prep	for,stained
R9603	T13684	T13685	nummod	5.5,h
R9604	T13685	T13683	pobj	h,for
R9605	T13686	T13681	punct	.,stained
R9606	T13688	T13689	amod	Similar,sections
R9607	T13689	T13692	nsubjpass	sections,prepared
R9608	T13690	T13689	amod	nonstained,sections
R9609	T13691	T13689	compound	skin,sections
R9610	T13693	T13692	auxpass	were,prepared
R9611	T13694	T13692	prep	from,prepared
R9612	T13695	T13694	pobj	animals,from
R9613	T13696	T13695	acl	carrying,animals
R9614	T13697	T13698	det	the,allele
R9615	T13698	T13696	dobj	allele,carrying
R9616	T13699	T13698	compound	at,allele
R9617	T13700	T13692	punct	.,prepared
R9618	T13702	T13703	nsubjpass	Images,aligned
R9619	T13704	T13702	prep	of,Images
R9620	T13705	T13706	det	the,fragments
R9621	T13706	T13704	pobj	fragments,of
R9622	T13707	T13706	amod	different,fragments
R9623	T13708	T13706	compound	skin,fragments
R9624	T13709	T13703	auxpass	were,aligned
R9625	T13710	T13703	cc	and,aligned
R9626	T13711	T13703	conj	scaled,aligned
R9627	T13712	T13703	punct	", ",aligned
R9628	T13713	T13703	cc	and,aligned
R9629	T13714	T13715	det	the,position
R9630	T13715	T13717	nsubjpass	position,measured
R9631	T13716	T13715	amod	relative,position
R9632	T13717	T13703	conj	measured,aligned
R9633	T13718	T13715	prep	of,position
R9634	T13719	T13720	det	the,plate
R9635	T13720	T13718	pobj	plate,of
R9636	T13721	T13722	npadvmod	somite,lateral
R9637	T13722	T13720	amod	lateral,plate
R9638	T13723	T13722	punct	–,lateral
R9639	T13724	T13720	cc	and,plate
R9640	T13725	T13726	det	the,boundaries
R9641	T13726	T13720	conj	boundaries,plate
R9642	T13727	T13726	compound	pigmentation,boundaries
R9643	T13728	T13717	auxpass	were,measured
R9644	T13729	T13717	advcl	using,measured
R9645	T13730	T13729	dobj	ImageJ,using
R9646	T13731	T13717	punct	.,measured
R9096	T12990	T12989	pobj	Russ,in
R9097	T12991	T12992	advmod	et,al.
R9098	T12992	T12990	advmod	al.,Russ
R4	T175	T174	compound	Mouse,Coat
R12	T185	T184	compound	animal,kingdom
R15	T188	T186	cc	or,coat
R16	T189	T190	compound	skin,color
R17	T190	T186	conj	color,coat
R21	T194	T193	amod	dorsoventral,axis
R38	T213	T214	det	a,mutation
R42	T217	T214	punct	", ",mutation
R43	T218	T219	amod	droopy,ear
R44	T219	T214	appos	ear,mutation
R45	T220	T219	punct	(,ear
R46	T221	T219	appos	deH,ear
R47	T222	T219	punct	),ear
R48	T223	T212	punct	", ",affects
R51	T226	T225	compound	skin,characteristics
R60	T235	T234	compound	Agouti,gene
R64	T240	T238	acl	carrying,Mice
R65	T241	T242	det	the,allele
R68	T244	T242	appos	black,allele
R69	T245	T244	punct	-,black
R70	T246	T244	cc	and,black
R71	T247	T248	punct	-,tan
R72	T248	T244	conj	tan,black
R73	T249	T244	punct	(,black
R74	T250	T244	appos	at,black
R75	T251	T239	punct	),have
R76	T252	T239	advmod	normally,have
R79	T256	T255	amod	sharp,boundary
R83	T260	T259	amod	black,hair
R87	T264	T263	amod	ventral,hair
R91	T268	T267	compound	deH,mutation
R94	T271	T270	compound	pigmentation,boundary
R99	T276	T275	amod	apparent,transformation
R100	T277	T275	amod	dorsal,transformation
R101	T278	T277	punct	-,dorsal
R102	T279	T277	prep	to,dorsal
R103	T280	T279	punct	-,to
R104	T281	T279	amod	ventral,to
R109	T288	T289	nummod	216,kb
R110	T289	T287	compound	kb,deletion
R119	T298	T297	amod	first,exon
R123	T302	T301	compound	Tbx15,gene
R127	T306	T305	amod	embryonic,expression
R129	T308	T305	prep	in,expression
R130	T309	T310	amod	developing,mesenchyme
R131	T310	T308	pobj	mesenchyme,in
R135	T314	T312	cc	and,pigmentary
R136	T315	T312	conj	skeletal,pigmentary
R141	T320	T319	punct	/,deH
R148	T329	T328	amod	targeted,allele
R153	T334	T335	det	the,phenotype
R156	T337	T333	auxpass	was,caused
R167	T349	T347	prep	of,expression
R168	T350	T349	pobj	Tbx15,of
R169	T351	T347	prep	in,expression
R170	T352	T353	amod	dorsal,mesenchyme
R171	T353	T351	pobj	mesenchyme,in
R202	T387	T388	amod	positional,identity
R1609	T2605	T2606	amod	differentiated,state
R1610	T2606	T2601	conj	state,number
R1611	T2607	T2601	prep	of,number
R1612	T2608	T2609	compound	pigment,cells
R1613	T2609	T2607	pobj	cells,of
R1614	T2610	T2601	punct	", ",number
R1615	T2611	T2612	advmod	as,as
R1618	T2614	T2615	det	the,type
R1619	T2615	T2601	conj	type,number
R1620	T2616	T2615	prep	of,type
R1621	T2617	T2616	pobj	pigment,of
R1622	T2618	T2615	acl	synthesized,type
R1623	T2619	T2618	prep	in,synthesized
R1624	T2620	T2619	pobj	response,in
R1625	T2621	T2620	prep	to,response
R1626	T2622	T2621	pobj	expression,to
R1627	T2623	T2622	prep	of,expression
R1628	T2624	T2623	pobj	Agouti,of
R1629	T2625	T2591	punct	.,represent
R1630	T2627	T2628	prep	In,vary
R1631	T2629	T2627	amod	particular,In
R1632	T2630	T2628	punct	", ",vary
R1633	T2631	T2632	amod	ventral,hair
R1634	T2632	T2628	nsubj	hair,vary
R1635	T2633	T2632	prep	of,hair
R1636	T2634	T2635	compound	at,at
R1639	T2637	T2633	pobj	animals,of
R1640	T2638	T2628	aux	can,vary
R1641	T2639	T2628	prep	from,vary
R1642	T2640	T2641	npadvmod	cream,colored
R1645	T2643	T2639	prep	to,from
R1646	T2644	T2645	amod	reddish,yellow
R1649	T2647	T2628	prep	depending,vary
R1650	T2648	T2647	prep	on,depending
R1651	T2649	T2648	pobj	age,on
R1652	T2650	T2649	punct	", ",age
R1653	T2651	T2652	compound	strain,background
R1654	T2652	T2649	conj	background,age
R1655	T2653	T2652	punct	", ",background
R1656	T2654	T2652	cc	and,background
R1657	T2655	T2652	conj	position,background
R1658	T2656	T2655	prep	along,position
R1659	T2657	T2658	det	the,axis
R1662	T2660	T2628	punct	.,vary
R1663	T2662	T2663	aux	To,evaluate
R1664	T2663	T2664	advcl	evaluate,compared
R1665	T2665	T2666	det	the,relationship
R1666	T2666	T2663	dobj	relationship,evaluate
R1667	T2667	T2666	prep	among,relationship
R1668	T2668	T2669	det	these,components
R1669	T2669	T2667	pobj	components,among
R1670	T2670	T2664	punct	", ",compared
R1671	T2671	T2664	nsubj	we,compared
R1672	T2672	T2673	poss	their,features
R1673	T2673	T2664	dobj	features,compared
R1674	T2674	T2664	prep	among,compared
R1675	T2675	T2674	pobj	mice,among
R1676	T2676	T2675	prep	of,mice
R1677	T2677	T2678	amod	different,genotypes
R1680	T2680	T2664	punct	.,compared
R1681	T2682	T2683	amod	Semiquantitative,measurements
R1682	T2683	T2684	nsubj	measurements,reveal
R1683	T2685	T2683	prep	of,measurements
R1684	T2686	T2687	compound	hair,length
R1685	T2687	T2685	pobj	length,of
R1686	T2688	T2683	acl	plotted,measurements
R1687	T2689	T2688	prep	as,plotted
R1688	T2690	T2691	det	a,function
R1689	T2691	T2689	pobj	function,as
R1690	T2692	T2691	prep	of,function
R1691	T2693	T2694	amod	dorsoventral,position
R1692	T2694	T2692	pobj	position,of
R1693	T2695	T2696	mark	that,coincides
R1707	T2709	T2711	compound	at,mice
R1710	T2712	T2696	prep	with,coincides
R1711	T2713	T2714	det	a,change
R1715	T2717	T2714	prep	in,change
R1716	T2718	T2719	preconj	both,color
R1719	T2721	T2719	cc	and,color
R1720	T2722	T2723	compound	hair,length
R1721	T2723	T2719	conj	length,color
R1722	T2724	T2725	punct	(,1A
R1725	T2727	T2728	punct	–,1D
R1726	T2728	T2725	prep	1D,1A
R1727	T2729	T2725	punct	),1A
R1728	T2730	T2684	punct	.,reveal
R1729	T2732	T2733	prep	Within,become
R1730	T2734	T2735	det	the,region
R1731	T2735	T2732	pobj	region,Within
R1732	T2736	T2735	prep	of,region
R1733	T2737	T2736	pobj	transition,of
R1734	T2738	T2737	prep	from,transition
R1735	T2739	T2738	pobj	dorsum,from
R1736	T2740	T2737	prep	to,transition
R1737	T2741	T2740	pobj	ventrum,to
R1738	T2742	T2743	punct	(,Figure
R1832	T2842	T2843	amod	different,age
R1833	T2843	T2841	pobj	age,of
R1834	T2844	T2843	punct	", ",age
R1835	T2845	T2843	conj	size,age
R1836	T2846	T2845	punct	", ",size
R1837	T2847	T2845	cc	and,size
R1838	T2848	T2849	compound	Agouti,genotype
R1839	T2849	T2845	conj	genotype,size
R1840	T2850	T2832	advmod	also,are
R1841	T2851	T2852	advmod	very,similar
R1842	T2852	T2832	acomp	similar,are
R1843	T2853	T2854	advmod	when,normalized
R1844	T2854	T2832	advcl	normalized,are
R1845	T2855	T2854	prep	to,normalized
R1846	T2856	T2857	compound	body,circumference
R1847	T2857	T2855	pobj	circumference,to
R1848	T2858	T2859	punct	(,Figure
R1960	T2978	T2976	nmod	al.,Forsthoefel
R1961	T2979	T2976	nummod	1966,Forsthoefel
R1962	T2980	T2976	punct	),Forsthoefel
R1963	T2981	T2962	punct	", ",disappear
R1964	T2982	T2962	cc	and,disappear
R1965	T2983	T2962	punct	", ",disappear
R1966	T2984	T2985	advmod	overall,is
R1973	T2991	T2989	pobj	types,of
R1975	T2993	T2994	advmod	also,similar
R1976	T2994	T2985	acomp	similar,is
R1977	T2995	T2985	prep	in,is
R1978	T2996	T2995	pobj	dorsa,in
R1979	T2997	T2996	cc	and,dorsa
R1980	T2998	T2996	conj	ventra,dorsa
R1981	T2999	T2996	prep	of,dorsa
R1982	T3000	T3001	amod	adult,mice
R1983	T3001	T2999	pobj	mice,of
R1984	T3002	T2985	punct	.,is
R1985	T3004	T3005	prep	In,observed
R1986	T3006	T3007	npadvmod	age,matched
R1991	T3011	T3005	punct	", ",observed
R1992	T3012	T3005	nsubj	we,observed
R1993	T3013	T3014	det	a,decrease
R1996	T3016	T3014	prep	in,decrease
R1997	T3017	T3018	det	the,ratio
R1998	T3018	T3016	pobj	ratio,in
R1999	T3019	T3018	prep	of,ratio
R2000	T3020	T3021	compound	undercoat,hairs
R2001	T3021	T3019	pobj	hairs,of
R2002	T3022	T3023	punct	(,zigzags
R2119	T3143	T3144	det	an,indicator
R2120	T3144	T3142	pobj	indicator,as
R2121	T3145	T3144	prep	of,indicator
R2122	T3146	T3147	compound	tyrosinase,activity
R2123	T3147	T3145	pobj	activity,of
R2124	T3148	T3139	punct	", ",observed
R2125	T3149	T3139	nsubj	we,observed
R2126	T3150	T3151	det	a,transition
R2130	T3154	T3139	prep	in,observed
R2131	T3155	T3156	amod	isolated,preparations
R2134	T3158	T3156	prep	from,preparations
R2135	T3159	T3160	compound	P4.5,mice
R2138	T3162	T3160	compound	ae,mice
R2140	T3164	T3165	punct	(,Figure
R2247	T3279	T3273	dative	dorsal,distinguish
R2248	T3280	T3273	prep	from,distinguish
R2249	T3281	T3280	pobj	ventral,from
R2250	T3282	T3273	dobj	skin,distinguish
R2251	T3283	T3273	punct	: ,distinguish
R2252	T3284	T3273	dobj	differences,distinguish
R2253	T3285	T3284	prep	in,differences
R2254	T3286	T3287	compound	pigment,type
R2257	T3289	T3285	pobj	synthesis,in
R2258	T3290	T3284	punct	(,differences
R2259	T3291	T3284	prep	depending,differences
R2260	T3292	T3291	prep	on,depending
R2261	T3293	T3294	compound	Agouti,genotype
R2262	T3294	T3292	pobj	genotype,on
R2263	T3295	T3284	punct	),differences
R2264	T3296	T3284	punct	", ",differences
R2265	T3297	T3284	conj	differences,differences
R2266	T3298	T3297	prep	in,differences
R2267	T3299	T3300	compound	hair,length
R2268	T3300	T3298	pobj	length,in
R2269	T3301	T3297	punct	", ",differences
R2270	T3302	T3297	cc	and,differences
R2271	T3303	T3297	conj	differences,differences
R2272	T3304	T3303	prep	in,differences
R2273	T3305	T3306	compound	melanin,content
R2274	T3306	T3304	pobj	content,in
R2275	T3307	T3273	punct	.,distinguish
R2283	T3541	T3539	pobj	Mutation,by
R2352	T3614	T3612	attr	characteristic,are
R2371	T3633	T3629	conj	area,fissures
R2587	T3857	T3855	pobj	stripe,as
R2622	T3892	T3883	conj	region,boundary
R2627	T3897	T3892	relcl	reduced,region
R2756	T4032	T4029	dobj	characteristics,affects
R2781	T4058	T4061	ccomp	causes,is
R431	T1103	T1104	prep	Among,are
R432	T1105	T1103	pobj	these,Among
R433	T1106	T1104	punct	", ",are
R434	T1107	T1108	compound	pigment,patterns
R435	T1108	T1104	nsubj	patterns,are
R436	T1109	T1110	det	an,system
R439	T1112	T1113	aux	to,investigate
R440	T1113	T1110	advcl	investigate,system
R441	T1114	T1115	advmod	how,arise
R445	T1118	T1115	punct	", ",arise
R446	T1119	T1120	preconj	both,for
R447	T1120	T1115	prep	for,arise
R448	T1121	T1122	amod	different,regions
R449	T1122	T1120	pobj	regions,for
R450	T1123	T1122	prep	of,regions
R451	T1124	T1125	det	the,body
R452	T1125	T1123	pobj	body,of
R453	T1126	T1122	prep	within,regions
R454	T1127	T1128	det	a,species
R455	T1128	T1126	pobj	species,within
R456	T1129	T1120	cc	and,for
R457	T1130	T1120	conj	for,for
R458	T1131	T1132	amod	different,animals
R459	T1132	T1130	pobj	animals,for
R460	T1133	T1132	prep	from,animals
R461	T1134	T1135	advmod	closely,related
R462	T1135	T1136	amod	related,species
R463	T1136	T1133	pobj	species,from
R464	T1137	T1104	punct	.,are
R465	T1139	T1140	prep	In,is
R472	T1147	T1148	det	a,mechanism
R476	T1151	T1148	prep	for,mechanism
R477	T1152	T1151	pobj	recognition,for
R478	T1153	T1152	punct	", ",recognition
R479	T1154	T1152	conj	camouflage,recognition
R480	T1155	T1154	punct	", ",camouflage
R481	T1156	T1154	cc	or,camouflage
R482	T1157	T1154	conj	both,camouflage
R483	T1158	T1146	punct	;,characterized
R484	T1159	T1146	advmod	consequently,characterized
R485	T1160	T1146	punct	", ",characterized
R486	T1161	T1162	det	a,number
R489	T1164	T1162	prep	of,number
R490	T1165	T1166	compound	pigment,patterns
R491	T1166	T1164	pobj	patterns,of
R492	T1167	T1146	aux	have,characterized
R493	T1168	T1146	auxpass	been,characterized
R494	T1169	T1146	prep	from,characterized
R495	T1170	T1171	det	an,perspective
R500	T1175	T1176	punct	(,Boughman
R501	T1176	T1146	meta	Boughman,characterized
R502	T1177	T1176	nummod	2001,Boughman
R503	T1178	T1176	punct	;,Boughman
R504	T1179	T1176	nmod	Jiggins,Boughman
R505	T1180	T1176	nmod	et,Boughman
R506	T1181	T1176	nmod	al.,Boughman
R507	T1182	T1176	nummod	2001,Boughman
R508	T1183	T1176	punct	),Boughman
R509	T1184	T1146	punct	.,characterized
R510	T1186	T1187	prep	In,been
R511	T1188	T1189	det	the,laboratory
R512	T1189	T1186	pobj	laboratory,In
R513	T1190	T1187	punct	", ",been
R514	T1191	T1192	compound	color,variation
R515	T1192	T1187	nsubj	variation,been
R516	T1193	T1187	aux	has,been
R517	T1194	T1195	det	the,subject
R518	T1195	T1187	attr	subject,been
R519	T1196	T1195	prep	of,subject
R520	T1197	T1198	compound	vertebrate,genetics
R521	T1198	T1196	pobj	genetics,of
R522	T1199	T1187	prep	for,been
R523	T1200	T1201	amod	more,a
R526	T1203	T1199	pobj	century,for
R527	T1204	T1205	punct	(,Searle
R528	T1205	T1187	meta	Searle,been
R529	T1206	T1205	nummod	1968,Searle
R530	T1207	T1205	punct	;,Searle
R531	T1208	T1205	nmod	Silvers,Searle
R532	T1209	T1205	nummod	1979,Searle
R533	T1210	T1205	punct	),Searle
R534	T1211	T1187	punct	", ",been
R535	T1212	T1187	cc	and,been
R536	T1213	T1214	amod	many,components
R542	T1219	T1220	poss	whose,actions
R543	T1220	T1221	dep	actions,understood
R546	T1223	T1221	prep	in,understood
R547	T1224	T1225	det	a,context
R552	T1229	T1226	conj	based,cellular
R554	T1231	T1232	punct	(,reviewed
R640	T1323	T1319	punct	;,Furumura
R641	T1324	T1319	appos	Barsh,Furumura
R642	T1325	T1326	advmod	et,al.
R643	T1326	T1324	advmod	al.,Barsh
R644	T1327	T1324	npadvmod	2000,Barsh
R645	T1328	T1317	punct	),reviewed
R646	T1329	T1291	punct	.,control
R647	T1331	T1332	advmod	Finally,makes
R648	T1333	T1332	punct	", ",makes
R649	T1334	T1332	nsubj	movement,makes
R650	T1335	T1334	prep	of,movement
R651	T1336	T1337	compound	pigment,granules
R652	T1337	T1335	pobj	granules,of
R653	T1338	T1334	prep	within,movement
R654	T1339	T1338	pobj	melanocytes,within
R655	T1340	T1338	cc	or,within
R656	T1341	T1338	conj	from,within
R657	T1342	T1341	pobj	melanocytes,from
R658	T1343	T1341	prep	to,from
R659	T1344	T1343	pobj	keratinocytes,to
R660	T1345	T1332	dobj	use,makes
R661	T1346	T1332	prep	of,makes
R662	T1347	T1348	amod	cellular,machinery
R663	T1348	T1346	pobj	machinery,of
R664	T1349	T1350	dep	that,shared
R667	T1352	T1350	agent	by,shared
R668	T1353	T1354	det	a,variety
R669	T1354	T1352	pobj	variety,by
R670	T1355	T1354	prep	of,variety
R671	T1356	T1357	compound	cell,types
R672	T1357	T1355	pobj	types,of
R673	T1358	T1350	punct	", ",shared
R674	T1359	T1350	cc	but,shared
R675	T1360	T1361	dep	that,vary
R678	T1363	T1361	prep	in,vary
R679	T1364	T1365	amod	different,regions
R680	T1365	T1363	pobj	regions,in
R681	T1366	T1365	prep	of,regions
R682	T1367	T1368	det	the,body
R683	T1368	T1366	pobj	body,of
R684	T1369	T1370	punct	(,reviewed
R798	T1489	T1487	pobj	color,in
R799	T1490	T1477	auxpass	is,brought
R800	T1491	T1477	prt	about,brought
R801	T1492	T1477	agent	by,brought
R802	T1493	T1492	pobj	differences,by
R803	T1494	T1493	prep	in,differences
R804	T1495	T1496	compound	pigment,type
R805	T1496	T1494	pobj	type,in
R806	T1497	T1498	mark	as,determined
R807	T1498	T1477	advcl	determined,brought
R808	T1499	T1498	agent	by,determined
R809	T1500	T1501	amod	allelic,variation
R810	T1501	T1499	pobj	variation,by
R811	T1502	T1501	prep	of,variation
R812	T1503	T1504	det	the,gene
R815	T1506	T1507	punct	(,Bultman
R816	T1507	T1477	meta	Bultman,brought
R817	T1508	T1507	nmod	et,Bultman
R818	T1509	T1507	nmod	al.,Bultman
R819	T1510	T1507	nummod	1992,Bultman
R820	T1511	T1507	punct	;,Bultman
R821	T1512	T1507	nmod	Miller,Bultman
R822	T1513	T1507	nmod	et,Bultman
R823	T1514	T1507	nmod	al.,Bultman
R824	T1515	T1507	nummod	1993,Bultman
R825	T1516	T1507	punct	),Bultman
R826	T1517	T1477	punct	.,brought
R827	T1519	T1520	advcl	Secreted,causes
R828	T1521	T1519	agent	by,Secreted
R829	T1522	T1523	amod	dermal,cells
R832	T1525	T1519	prep	within,Secreted
R833	T1526	T1527	det	each,follicle
R836	T1529	T1530	punct	(,Millar
R837	T1530	T1519	meta	Millar,Secreted
R838	T1531	T1530	nmod	et,Millar
R839	T1532	T1530	nmod	al.,Millar
R840	T1533	T1530	nummod	1995,Millar
R841	T1534	T1530	punct	),Millar
R842	T1535	T1520	punct	", ",causes
R843	T1536	T1537	compound	Agouti,protein
R844	T1537	T1520	nsubj	protein,causes
R845	T1538	T1539	nsubj	melanocytes,switch
R851	T1544	T1539	prep	from,switch
R852	T1545	T1546	det	the,production
R853	T1546	T1544	pobj	production,from
R854	T1547	T1546	prep	of,production
R855	T1548	T1549	amod	brown,black
R858	T1551	T1547	pobj	eumelanin,of
R859	T1552	T1539	prep	to,switch
R860	T1553	T1554	amod	red,yellow
R863	T1556	T1552	pobj	pheomelanin,to
R864	T1557	T1520	punct	.,causes
R865	T1559	T1560	compound	Agouti,protein
R866	T1560	T1561	nsubj	protein,has
R867	T1561	T1562	ccomp	has,thought
R868	T1563	T1564	det	a,radius
R871	T1566	T1564	prep	of,radius
R872	T1567	T1566	pobj	action,of
R873	T1568	T1569	punct	(,Silvers
R874	T1569	T1564	meta	Silvers,radius
R875	T1570	T1569	cc	and,Silvers
R876	T1571	T1569	conj	Russel,Silvers
R877	T1572	T1571	nummod	1955,Russel
R878	T1573	T1571	punct	),Russel
R879	T1574	T1561	cc	and,has
R880	T1575	T1576	aux	can,switched
R883	T1578	T1576	prt	on,switched
R884	T1579	T1578	cc	and,on
R885	T1580	T1578	conj	off,on
R886	T1581	T1576	prep	during,switched
R887	T1582	T1583	det	a,cycle
R891	T1586	T1587	punct	(,Bultman
R892	T1587	T1576	meta	Bultman,switched
R893	T1588	T1587	nmod	et,Bultman
R894	T1589	T1587	nmod	al.,Bultman
R895	T1590	T1587	nummod	1992,Bultman
R896	T1591	T1587	punct	", ",Bultman
R897	T1592	T1587	nummod	1994,Bultman
R898	T1593	T1587	punct	;,Bultman
R899	T1594	T1587	nmod	Miller,Bultman
R900	T1595	T1587	nmod	et,Bultman
R901	T1596	T1587	nmod	al.,Bultman
R902	T1597	T1587	nummod	1993,Bultman
R903	T1598	T1587	punct	;,Bultman
R904	T1599	T1587	nmod	Vrieling,Bultman
R905	T1600	T1587	nmod	et,Bultman
R906	T1601	T1587	nmod	al.,Bultman
R907	T1602	T1587	nummod	1994,Bultman
R908	T1603	T1587	punct	),Bultman
R909	T1604	T1562	punct	;,thought
R910	T1605	T1562	advmod	thus,thought
R911	T1606	T1562	punct	", ",thought
R912	T1607	T1608	poss	its,expression
R915	T1610	T1562	auxpass	is,thought
R916	T1611	T1612	aux	to,be
R917	T1612	T1562	xcomp	be,thought
R918	T1613	T1612	acomp	responsible,be
R919	T1614	T1613	prep	for,responsible
R920	T1615	T1616	det	the,surface
R923	T1618	T1616	amod	colored,surface
R928	T1623	T1616	prep	of,surface
R929	T1624	T1623	pobj	mice,of
R930	T1625	T1624	acl	carrying,mice
R931	T1626	T1627	det	the,allele
R941	T1636	T1614	cc	and,for
R942	T1637	T1614	conj	for,for
R943	T1638	T1639	det	the,markings
R946	T1641	T1639	prep	around,markings
R947	T1642	T1643	det	the,feet
R948	T1643	T1641	pobj	feet,around
R949	T1644	T1643	punct	", ",feet
R950	T1645	T1643	conj	ears,feet
R951	T1646	T1645	punct	", ",ears
R952	T1647	T1645	cc	or,ears
R953	T1648	T1645	conj	head,ears
R954	T1649	T1639	punct	", ",markings
R955	T1650	T1651	advmod	i.e.,points
R959	T1654	T1651	cc	or,points
R960	T1655	T1656	compound	head,spots
R961	T1656	T1651	conj	spots,points
R962	T1657	T1639	punct	", ",markings
R963	T1658	T1639	prep	of,markings
R964	T1659	T1660	amod	certain,breeds
R967	T1662	T1562	punct	.,thought
R968	T1664	T1665	prep	In,identified
R969	T1666	T1667	compound	laboratory,mice
R970	T1667	T1664	pobj	mice,In
R971	T1668	T1665	punct	", ",identified
R972	T1669	T1670	amod	previous,studies
R973	T1670	T1665	nsubj	studies,identified
R974	T1671	T1670	prep	from,studies
R1120	T1822	T1823	amod	Ventral,specific
R1412	T2126	T2127	nsubj	We,make
R1413	T2128	T2127	advmod	also,make
R1414	T2129	T2127	dobj	use,make
R1415	T2130	T2127	prep	of,make
R1416	T2131	T2132	det	a,mutation
R1467	T2239	T2240	det	the,flank
R1468	T2240	T2238	pobj	flank,of
R1470	T2241	T2240	amod	developing,flank
R1471	T2242	T2223	punct	.,suggest
R1473	T2244	T2245	det	These,results
R1474	T2245	T2246	nsubj	results,identify
R1475	T2247	T2248	det	a,aspect
R1477	T2248	T2246	dobj	aspect,identify
R1478	T2249	T2250	advmod	previously,unappreciated
R1479	T2250	T2248	amod	unappreciated,aspect
R1481	T2251	T2248	prep	of,aspect
R1482	T2252	T2253	amod	dorsoventral,patterning
R1483	T2253	T2251	pobj	patterning,of
R1484	T2254	T2255	dep	that,represented
R1486	T2255	T2248	relcl	represented,aspect
R1487	T2256	T2255	auxpass	is,represented
R1488	T2257	T2255	advmod	widely,represented
R1490	T2258	T2255	prep	in,represented
R1491	T2259	T2260	amod	furred,mammals
R1493	T2260	T2258	pobj	mammals,in
R1494	T2261	T2255	cc	and,represented
R1495	T2262	T2255	conj	provide,represented
R1496	T2263	T2262	dobj	insight,provide
R1498	T2264	T2263	prep	into,insight
R1499	T2265	T2266	det	the,mechanisms
R1500	T2266	T2264	pobj	mechanisms,into
R1502	T2267	T2268	dep	that,underlie
R1503	T2268	T2266	relcl	underlie,mechanisms
R1504	T2269	T2270	npadvmod	region,specific
R1506	T2270	T2272	amod	specific,differences
R1507	T2271	T2270	punct	-,specific
R1508	T2272	T2268	dobj	differences,underlie
R1510	T2273	T2272	prep	in,differences
R1511	T2274	T2275	compound	body,morphology
R1513	T2275	T2273	pobj	morphology,in
R1514	T2276	T2246	punct	.,identify
R9083	T12974	T12975	compound	Gene,targeting
R9084	T12977	T12978	det	A,allele
R9085	T12978	T12980	nsubjpass	allele,constructed
R9086	T12979	T12978	amod	targeted,allele
R9087	T12981	T12978	prep	of,allele
R9088	T12982	T12981	pobj	Tbx15,of
R9089	T12983	T12980	auxpass	was,constructed
R9090	T12984	T12980	advcl	using,constructed
R9091	T12985	T12986	det	the,approach
R9092	T12986	T12984	dobj	approach,using
R9093	T12987	T12986	amod	same,approach
R9094	T12988	T12986	acl	described,approach
R9095	T12989	T12988	prep	in,described
R203	T388	T386	nsubjpass	identity,acquired
R204	T389	T388	prep	of,identity
R205	T390	T391	det	the,skin
R206	T391	T389	pobj	skin,of
R207	T392	T388	prep	with,identity
R208	T393	T392	pobj	regard,with
R209	T394	T393	prep	to,regard
R210	T395	T396	amod	dorsoventral,differences
R213	T398	T386	auxpass	is,acquired
R229	T415	T414	punct	-,mapping
R233	T420	T421	det	the,boundary
R243	T430	T431	advmod	previously,identified
R244	T431	T429	amod	identified,boundary
R245	T432	T433	amod	dermal,cell
R246	T433	T434	compound	cell,lineage
R247	T434	T429	compound	lineage,boundary
R254	T441	T440	nmod	limb,boundary
R255	T442	T440	amod	dorsoventral,boundary
R266	T455	T454	amod	instructional,cue
R272	T461	T460	amod	future,identity
R273	T462	T460	amod	positional,identity
R282	T473	T472	amod	novel,role
R286	T477	T476	punct	-,box
R288	T479	T478	compound	gene,action
R296	T487	T488	advmod	previously,unappreciated
R297	T488	T486	amod	unappreciated,aspect
R303	T494	T493	auxpass	is,represented
R304	T495	T493	advmod	widely,represented
R319	T510	T509	punct	-,specific
R4287	T6292	T6280	ccomp	gives,showed
R4112	T5938	T5935	advcl	explained,are
R3254	T4788	T4778	conj	sequence,information
R3488	T5035	T5040	advcl	was,generated
R5959	T8677	T8675	ccomp	been,suggest
R1556	T2547	T2548	amod	Morphological,Components
R1557	T2549	T2548	prep	of,Components
R1558	T2550	T2551	amod	Dorsoventral,Differences
R1561	T2554	T2555	prep	Besides,suggests
R1562	T2556	T2557	det	the,change
R1565	T2559	T2557	prep	in,change
R1566	T2560	T2561	compound	hair,color
R1567	T2561	T2559	pobj	color,in
R1568	T2562	T2563	dep	that,distinguishes
R1571	T2565	T2563	dative	dorsal,distinguishes
R1572	T2566	T2563	prep	from,distinguishes
R1573	T2567	T2566	pobj	ventral,from
R1574	T2568	T2563	dobj	skin,distinguishes
R1575	T2569	T2555	punct	", ",suggests
R1576	T2570	T2571	amod	casual,observation
R1577	T2571	T2555	nsubj	observation,suggests
R1578	T2572	T2573	expl	there,are
R1579	T2573	T2555	advcl	are,suggests
R1580	T2574	T2575	amod	additional,differences
R1581	T2575	T2573	attr	differences,are
R1582	T2576	T2575	prep	in,differences
R1583	T2577	T2578	compound	hair,length
R1584	T2578	T2576	pobj	length,in
R1585	T2579	T2578	punct	", ",length
R1586	T2580	T2578	conj	distribution,length
R1587	T2581	T2580	prep	of,distribution
R1588	T2582	T2583	compound	hair,type
R1589	T2583	T2581	pobj	type,of
R1590	T2584	T2580	punct	", ",distribution
R1591	T2585	T2580	cc	and,distribution
R1592	T2586	T2587	compound	skin,thickness
R1593	T2587	T2580	conj	thickness,distribution
R1594	T2588	T2555	punct	.,suggests
R1595	T2590	T2591	advmod	Furthermore,represent
R1596	T2592	T2591	punct	", ",represent
R1597	T2593	T2594	amod	dorsoventral,differences
R1598	T2594	T2591	nsubj	differences,represent
R1599	T2595	T2594	prep	in,differences
R1600	T2596	T2595	pobj	pigmentation,in
R1601	T2597	T2591	aux	can,represent
R1602	T2598	T2591	dobj	differences,represent
R1603	T2599	T2598	prep	in,differences
R1604	T2600	T2601	det	the,number
R1605	T2601	T2599	pobj	number,in
R1606	T2602	T2601	cc	and,number
R1607	T2603	T2602	punct	/,and
R1608	T2604	T2602	cc	or,and
R1739	T2743	T2735	parataxis	Figure,region
R1740	T2744	T2743	nummod	1B,Figure
R1741	T2745	T2743	punct	),Figure
R1742	T2746	T2733	punct	", ",become
R1743	T2747	T2748	compound	flank,hairs
R1744	T2748	T2733	nsubj	hairs,become
R1745	T2749	T2748	prep	from,hairs
R1746	T2750	T2751	compound	at,at
R1749	T2753	T2749	pobj	mice,from
R1750	T2754	T2755	advmod	progressively,shorter
R1751	T2755	T2733	acomp	shorter,become
R1752	T2756	T2733	cc	and,become
R1753	T2757	T2733	conj	exhibit,become
R1754	T2758	T2759	amod	increasing,amounts
R1755	T2759	T2757	dobj	amounts,exhibit
R1756	T2760	T2759	prep	of,amounts
R1757	T2761	T2762	compound	pheomelanin,deposition
R1758	T2762	T2760	pobj	deposition,of
R1759	T2763	T2762	amod	progressing,deposition
R1760	T2764	T2757	prep	from,exhibit
R1761	T2765	T2766	det	the,tip
R1762	T2766	T2764	pobj	tip,from
R1763	T2767	T2764	prep	to,from
R1764	T2768	T2769	det	the,base
R1765	T2769	T2767	pobj	base,to
R1766	T2770	T2764	prep	of,from
R1767	T2771	T2772	det	the,hair
R1768	T2772	T2770	pobj	hair,of
R1769	T2773	T2733	punct	.,become
R1770	T2775	T2776	advmod	However,is
R1771	T2777	T2776	punct	", ",is
R1772	T2778	T2779	det	the,region
R1773	T2779	T2776	nsubj	region,is
R1774	T2780	T2779	prep	of,region
R1775	T2781	T2780	pobj	transition,of
R1776	T2782	T2776	prep	for,is
R1777	T2783	T2784	compound	hair,length
R1778	T2784	T2782	pobj	length,for
R1779	T2785	T2786	advmod	considerably,broader
R1780	T2786	T2776	acomp	broader,is
R1781	T2787	T2786	prep	than,broader
R1782	T2788	T2787	pobj	that,than
R1783	T2789	T2788	prep	for,that
R1784	T2790	T2789	pobj	pigmentation,for
R1785	T2791	T2786	cc	and,broader
R1786	T2792	T2786	conj	independent,broader
R1787	T2793	T2792	prep	of,independent
R1788	T2794	T2795	compound	Agouti,genotype
R1789	T2795	T2793	pobj	genotype,of
R1790	T2796	T2776	punct	.,is
R1791	T2798	T2799	mark	Although,varies
R1794	T2801	T2803	compound	cycle,timing
R1797	T2805	T2799	prep	along,varies
R1798	T2806	T2807	det	the,axis
R1801	T2809	T2804	punct	", ",are
R1802	T2810	T2804	nsubj	measurements,are
R1803	T2811	T2810	prep	of,measurements
R1804	T2812	T2813	amod	absolute,length
R1807	T2815	T2810	prep	for,measurements
R1808	T2816	T2815	pobj	mice,for
R1809	T2817	T2816	acl	matched,mice
R1810	T2818	T2817	prep	for,matched
R1811	T2819	T2818	pobj	age,for
R1812	T2820	T2819	cc	and,age
R1813	T2821	T2822	amod	rostrocaudal,level
R1814	T2822	T2819	conj	level,age
R1815	T2823	T2824	advmod	remarkably,similar
R1816	T2824	T2804	acomp	similar,are
R1817	T2825	T2826	punct	(,Figure
R1818	T2826	T2804	parataxis	Figure,are
R1819	T2827	T2826	nummod	1D,Figure
R1820	T2828	T2826	punct	),Figure
R1821	T2829	T2804	punct	.,are
R1822	T2831	T2832	advmod	Furthermore,are
R1823	T2833	T2832	punct	", ",are
R1824	T2834	T2832	nsubj	measurements,are
R1825	T2835	T2834	prep	of,measurements
R1826	T2836	T2837	amod	relative,length
R1829	T2839	T2832	prep	for,are
R1830	T2840	T2839	pobj	animals,for
R1831	T2841	T2840	prep	of,animals
R1849	T2859	T2832	parataxis	Figure,are
R1850	T2860	T2859	nummod	1C,Figure
R1851	T2861	T2859	punct	),Figure
R1852	T2862	T2832	punct	.,are
R1853	T2864	T2865	advcl	Taken,indicate
R1854	T2866	T2864	advmod	together,Taken
R1855	T2867	T2865	punct	", ",indicate
R1856	T2868	T2869	det	these,observations
R1857	T2869	T2865	nsubj	observations,indicate
R1858	T2870	T2871	mark	that,stereotyped
R1866	T2878	T2876	pobj	axis,along
R1869	T2881	T2871	cc	and,stereotyped
R1870	T2882	T2871	conj	maintained,stereotyped
R1871	T2883	T2871	prep	through,stereotyped
R1872	T2884	T2885	amod	multiple,cycles
R1875	T2887	T2871	punct	", ",stereotyped
R1876	T2888	T2871	prep	with,stereotyped
R1877	T2889	T2890	det	a,transition
R1878	T2890	T2888	pobj	transition,with
R1879	T2891	T2890	prep	in,transition
R1880	T2892	T2893	compound	hair,length
R1881	T2893	T2891	pobj	length,in
R1882	T2894	T2895	dep	that,is
R1883	T2895	T2890	relcl	is,transition
R1884	T2896	T2895	acomp	gradual,is
R1885	T2897	T2895	cc	and,is
R1886	T2898	T2895	conj	encompasses,is
R1887	T2899	T2900	det	the,transition
R1890	T2902	T2900	compound	type,transition
R1892	T2904	T2895	prep	in,is
R1893	T2905	T2906	compound	at,at
R1896	T2908	T2904	pobj	mice,in
R1897	T2909	T2865	punct	.,indicate
R1898	T2911	T2912	amod	Dorsal,skin
R1902	T2916	T2915	prep	at,develop
R1903	T2917	T2918	amod	different,rates
R1904	T2918	T2916	pobj	rates,at
R1905	T2919	T2915	punct	.,develop
R1906	T2921	T2922	amod	Transverse,sections
R1907	T2922	T2923	nsubj	sections,exhibit
R1908	T2924	T2922	prep	of,sections
R1909	T2925	T2924	pobj	skin,of
R1910	T2926	T2922	prep	at,sections
R1911	T2927	T2928	amod	postnatal,day
R1912	T2928	T2926	pobj	day,at
R1913	T2929	T2928	nummod	4.5,day
R1914	T2930	T2928	punct	(,day
R1915	T2931	T2928	appos	P4.5,day
R1916	T2932	T2928	punct	),day
R1917	T2933	T2934	amod	dorsal,follicles
R1920	T2936	T2937	dep	that,are
R1921	T2937	T2934	relcl	are,follicles
R1922	T2938	T2939	advmod	noticeably,developed
R1925	T2941	T2939	prep	than,developed
R1926	T2942	T2943	amod	ventral,follicles
R1929	T2945	T2934	punct	", ",follicles
R1930	T2946	T2934	prep	along,follicles
R1931	T2947	T2946	prep	with,along
R1932	T2948	T2949	det	a,decrease
R1936	T2952	T2949	prep	in,decrease
R1937	T2953	T2954	amod	dermal,thickness
R1938	T2954	T2952	pobj	thickness,in
R1939	T2955	T2956	punct	(,Figure
R1940	T2956	T2923	parataxis	Figure,exhibit
R1941	T2957	T2956	nummod	1F,Figure
R1942	T2958	T2956	punct	),Figure
R1943	T2959	T2923	punct	.,exhibit
R1944	T2961	T2962	advmod	However,disappear
R1945	T2963	T2962	punct	", ",disappear
R1946	T2964	T2962	nsubj	differences,disappear
R1947	T2965	T2964	prep	in,differences
R1948	T2966	T2967	compound	skin,thickness
R1949	T2967	T2965	pobj	thickness,in
R1950	T2968	T2962	prep	by,disappear
R1951	T2969	T2970	quantmod	3,4
R1954	T2972	T2968	pobj	wk,by
R1955	T2973	T2972	prep	of,wk
R1956	T2974	T2973	pobj	age,of
R1957	T2975	T2976	punct	(,Forsthoefel
R1958	T2976	T2962	meta	Forsthoefel,disappear
R1959	T2977	T2976	nmod	et,Forsthoefel
R2003	T3023	T3021	parataxis	zigzags,hairs
R2004	T3024	T3023	punct	),zigzags
R2005	T3025	T3018	prep	to,ratio
R2006	T3026	T3027	compound	overcoat,hairs
R2007	T3027	T3025	pobj	hairs,to
R2008	T3028	T3027	punct	(,hairs
R2009	T3029	T3027	appos	auchenes,hairs
R2010	T3030	T3029	punct	", ",auchenes
R2011	T3031	T3029	conj	awls,auchenes
R2012	T3032	T3031	punct	", ",awls
R2013	T3033	T3031	cc	and,awls
R2014	T3034	T3035	compound	guard,hairs
R2015	T3035	T3031	conj	hairs,awls
R2016	T3036	T3005	punct	),observed
R2017	T3037	T3005	prep	in,observed
R2018	T3038	T3037	pobj	dorsum,in
R2019	T3039	T3005	prep	compared,observed
R2020	T3040	T3039	prep	to,compared
R2021	T3041	T3040	pobj	ventrum,to
R2022	T3042	T3043	punct	(,Figure
R2023	T3043	T3005	parataxis	Figure,observed
R2024	T3044	T3043	nummod	1E,Figure
R2025	T3045	T3043	punct	),Figure
R2026	T3046	T3005	punct	", ",observed
R2027	T3047	T3005	cc	but,observed
R2028	T3048	T3049	expl	there,was
R2029	T3049	T3005	conj	was,observed
R2030	T3050	T3051	det	no,difference
R2033	T3053	T3051	prep	in,difference
R2034	T3054	T3055	compound	hair,type
R2037	T3057	T3053	pobj	distribution,in
R2038	T3058	T3057	prep	for,distribution
R2039	T3059	T3060	amod	outbred,mice
R2040	T3060	T3058	pobj	mice,for
R2041	T3061	T3062	punct	(,shown
R2045	T3065	T3062	punct	),shown
R2046	T3066	T3049	punct	.,was
R2047	T3068	T3069	nsubjpass	Differences,attributed
R2048	T3070	T3068	prep	between,Differences
R2049	T3071	T3072	amod	dorsal,pigmentation
R2053	T3075	T3072	prep	of,pigmentation
R2054	T3076	T3077	compound	at,at
R2057	T3079	T3075	pobj	mice,of
R2058	T3080	T3069	auxpass	are,attributed
R2059	T3081	T3069	advmod	usually,attributed
R2060	T3082	T3069	prep	to,attributed
R2061	T3083	T3084	compound	pigment,type
R2064	T3086	T3082	pobj	differences,to
R2065	T3087	T3086	acl	caused,differences
R2066	T3088	T3087	agent	by,caused
R2067	T3089	T3090	amod	ventral,specific
R2070	T3092	T3088	pobj	expression,by
R2071	T3093	T3092	prep	of,expression
R2072	T3094	T3093	pobj	Agouti,of
R2073	T3095	T3069	punct	", ",attributed
R2074	T3096	T3069	cc	but,attributed
R2075	T3097	T3098	nsubj	animals,have
R2080	T3102	T3100	pobj	allele,for
R2091	T3113	T3114	amod	ventral,hairs
R2092	T3114	T3098	dobj	hairs,have
R2093	T3115	T3116	dep	that,contain
R2094	T3116	T3114	relcl	contain,hairs
R2095	T3117	T3118	amod	less,melanin
R2096	T3118	T3116	dobj	melanin,contain
R2097	T3119	T3118	prep	than,melanin
R2098	T3120	T3121	amod	dorsal,hairs
R2099	T3121	T3119	pobj	hairs,than
R2100	T3122	T3116	punct	", ",contain
R2101	T3123	T3116	advcl	giving,contain
R2102	T3124	T3125	det	a,appearance
R2106	T3128	T3123	dative	to,giving
R2107	T3129	T3130	det	the,coat
R2110	T3132	T3133	punct	(,Figure
R2111	T3133	T3098	parataxis	Figure,have
R2112	T3134	T3133	nummod	1G,Figure
R2113	T3135	T3133	punct	),Figure
R2114	T3136	T3098	punct	.,have
R2115	T3138	T3139	advcl	Using,observed
R2116	T3140	T3141	compound	DOPA,staining
R2117	T3141	T3138	dobj	staining,Using
R2118	T3142	T3138	prep	as,Using
R2141	T3165	T3139	parataxis	Figure,observed
R2142	T3166	T3165	nummod	1G,Figure
R2143	T3167	T3165	punct	),Figure
R2144	T3168	T3139	punct	.,observed
R2145	T3170	T3171	prep	By,reveal
R2146	T3172	T3170	pobj	contrast,By
R2147	T3173	T3171	punct	", ",reveal
R2148	T3174	T3171	nsubj	skin,reveal
R2149	T3175	T3174	prep	from,skin
R2150	T3176	T3177	compound	at,at
R2153	T3179	T3175	pobj	mice,from
R2154	T3180	T3181	det	an,transition
R2158	T3184	T3181	prep	of,transition
R2159	T3185	T3186	compound	DOPA,staining
R2160	T3186	T3184	pobj	staining,of
R2161	T3187	T3181	punct	", ",transition
R2162	T3188	T3189	dep	which,reflects
R2165	T3191	T3192	det	the,effects
R2168	T3194	T3192	prep	of,effects
R2169	T3195	T3196	amod	reduced,content
R2172	T3198	T3196	punct	(,content
R2173	T3199	T3196	prep	as,content
R2174	T3200	T3199	prep	in,as
R2175	T3201	T3202	compound	ae,ae
R2178	T3204	T3200	pobj	mice,in
R2179	T3205	T3192	punct	),effects
R2180	T3206	T3192	cc	and,effects
R2181	T3207	T3192	conj	downregulation,effects
R2182	T3208	T3207	prep	of,downregulation
R2183	T3209	T3210	compound	tyrosinase,activity
R2184	T3210	T3208	pobj	activity,of
R2185	T3211	T3210	acl	induced,activity
R2186	T3212	T3211	agent	by,induced
R2187	T3213	T3212	pobj	Agouti,by
R2188	T3214	T3171	punct	.,reveal
R2189	T3216	T3217	compound	Melanin,content
R2190	T3217	T3218	nsubj	content,is
R2191	T3219	T3217	prep	of,content
R2192	T3220	T3221	amod	individual,hairs
R2193	T3221	T3219	pobj	hairs,of
R2194	T3222	T3218	acomp	likely,is
R2195	T3223	T3224	aux	to,influenced
R2198	T3226	T3227	preconj	both,by
R2199	T3227	T3224	agent	by,influenced
R2200	T3228	T3229	det	the,number
R2201	T3229	T3227	pobj	number,by
R2202	T3230	T3229	prep	of,number
R2203	T3231	T3232	compound	pigment,cells
R2204	T3232	T3230	pobj	cells,of
R2205	T3233	T3229	cc	and,number
R2206	T3234	T3235	poss	their,environment
R2209	T3237	T3218	punct	.,is
R2210	T3239	T3240	advmod	Regardless,persist
R2211	T3241	T3240	punct	", ",persist
R2212	T3242	T3243	amod	dorsoventral,differences
R2213	T3243	T3240	nsubj	differences,persist
R2214	T3244	T3243	prep	in,differences
R2215	T3245	T3246	compound	hair,content
R2218	T3248	T3246	prep	of,content
R2219	T3249	T3250	compound	ae,ae
R2222	T3252	T3248	pobj	mice,of
R2223	T3253	T3240	prep	throughout,persist
R2224	T3254	T3255	amod	multiple,cycles
R2227	T3257	T3240	prep	into,persist
R2228	T3258	T3257	pobj	adulthood,into
R2229	T3259	T3240	punct	", ",persist
R2230	T3260	T3240	advcl	similar,persist
R2231	T3261	T3260	prep	to,similar
R2232	T3262	T3263	compound	hair,length
R2233	T3263	T3261	pobj	length,to
R2234	T3264	T3260	punct	(,similar
R2235	T3265	T3260	cc	but,similar
R2236	T3266	T3260	conj	unlike,similar
R2237	T3267	T3268	compound	skin,thickness
R2238	T3268	T3266	pobj	thickness,unlike
R2239	T3269	T3240	punct	),persist
R2240	T3270	T3240	punct	.,persist
R2241	T3272	T3273	advmod	Thus,distinguish
R2242	T3274	T3273	punct	", ",distinguish
R2243	T3275	T3276	advmod	at,three
R2246	T3278	T3273	nsubj	characteristics,distinguish
R2848	T4128	T4121	parataxis	shown,display
R2871	T4153	T4151	pobj	days,in
R3021	T4311	T4309	pobj	skin,between
R326	T992	T993	det	A,question
R329	T996	T993	prep	in,question
R330	T997	T998	amod	developmental,biology
R331	T998	T996	pobj	biology,in
R332	T999	T1000	advmod	how,acquire
R338	T1005	T1003	pobj	body,of
R340	T1007	T1000	dobj	differences,acquire
R341	T1008	T1007	prep	in,differences
R342	T1009	T1010	poss	their,appearance
R343	T1010	T1008	pobj	appearance,in
R344	T1011	T1010	cc	or,appearance
R345	T1012	T1010	conj	morphology,appearance
R346	T1013	T995	punct	.,is
R347	T1015	T1016	nsubj	Mechanisms,make
R348	T1017	T1018	dep	that,establish
R349	T1018	T1015	relcl	establish,Mechanisms
R350	T1019	T1020	det	the,plan
R354	T1023	T1016	dobj	use,make
R355	T1024	T1016	prep	of,make
R356	T1025	T1026	det	a,number
R360	T1029	T1026	prep	of,number
R361	T1030	T1031	compound	signaling,pathways
R362	T1031	T1029	pobj	pathways,of
R363	T1032	T1031	acl	shared,pathways
R364	T1033	T1032	prep	among,shared
R365	T1034	T1035	det	all,animals
R366	T1035	T1033	pobj	animals,among
R367	T1036	T1037	punct	(,reviewed
R368	T1037	T1016	parataxis	reviewed,make
R369	T1038	T1037	prep	in,reviewed
R370	T1039	T1040	compound	Pires,daSilva
R373	T1042	T1040	cc	and,daSilva
R374	T1043	T1040	conj	Sommer,daSilva
R375	T1044	T1040	npadvmod	2003,daSilva
R376	T1045	T1037	punct	),reviewed
R377	T1046	T1016	punct	", ",make
R378	T1047	T1016	cc	but,make
R379	T1048	T1049	det	the,extent
R380	T1049	T1050	nsubj	extent,is
R392	T1061	T1050	neg	not,is
R393	T1062	T1050	acomp	clear,is
R394	T1063	T1050	punct	.,is
R395	T1065	T1066	prep	Among,combine
R396	T1067	T1065	pobj	vertebrates,Among
R397	T1068	T1066	punct	", ",combine
R398	T1069	T1066	nsubj	differences,combine
R399	T1070	T1069	prep	in,differences
R400	T1071	T1072	det	the,shape
R401	T1072	T1070	pobj	shape,in
R402	T1073	T1072	cc	or,shape
R403	T1074	T1072	conj	number,shape
R404	T1075	T1072	prep	of,shape
R405	T1076	T1077	amod	skeletal,elements
R406	T1077	T1075	pobj	elements,of
R407	T1078	T1072	punct	", ",shape
R408	T1079	T1080	amod	altered,morphology
R409	T1080	T1072	conj	morphology,shape
R410	T1081	T1080	prep	of,morphology
R411	T1082	T1083	amod	epidermal,appendages
R412	T1083	T1081	pobj	appendages,of
R413	T1084	T1080	punct	", ",morphology
R414	T1085	T1080	cc	and,morphology
R415	T1086	T1080	conj	variation,morphology
R416	T1087	T1086	prep	in,variation
R417	T1088	T1089	compound	pigment,distribution
R418	T1089	T1087	pobj	distribution,in
R419	T1090	T1091	aux	to,produce
R420	T1091	T1066	advcl	produce,combine
R421	T1092	T1093	det	the,majority
R422	T1093	T1091	dobj	majority,produce
R423	T1094	T1093	prep	of,majority
R424	T1095	T1096	dep	what,distinguishes
R425	T1096	T1094	pcomp	distinguishes,of
R426	T1097	T1098	nummod	one,animal
R427	T1098	T1096	dobj	animal,distinguishes
R428	T1099	T1096	prep	from,distinguishes
R429	T1100	T1099	pobj	another,from
R430	T1101	T1066	punct	.,combine
R555	T1232	T1221	parataxis	reviewed,understood
R556	T1233	T1232	prep	in,reviewed
R557	T1234	T1233	pobj	Bennett,in
R558	T1235	T1234	cc	and,Bennett
R559	T1236	T1234	conj	Lamoreux,Bennett
R560	T1237	T1234	npadvmod	2003,Bennett
R561	T1238	T1232	punct	),reviewed
R562	T1239	T1216	punct	.,identified
R563	T1241	T1242	amod	Several,mechanisms
R564	T1242	T1243	nsubj	mechanisms,contribute
R565	T1244	T1243	aux	may,contribute
R566	T1245	T1243	prep	to,contribute
R567	T1246	T1247	amod	regional,differences
R568	T1247	T1245	pobj	differences,to
R569	T1248	T1247	prep	in,differences
R570	T1249	T1250	compound	vertebrate,pigmentation
R571	T1250	T1248	pobj	pigmentation,in
R572	T1251	T1243	punct	.,contribute
R573	T1253	T1254	prep	In,affect
R574	T1255	T1256	det	the,embryo
R575	T1256	T1253	pobj	embryo,In
R576	T1257	T1254	punct	", ",affect
R577	T1258	T1254	nsubj	alterations,affect
R578	T1259	T1258	prep	in,alterations
R579	T1260	T1261	det	the,determination
R580	T1261	T1259	pobj	determination,in
R581	T1262	T1261	cc	or,determination
R582	T1263	T1261	conj	migration,determination
R583	T1264	T1261	prep	of,determination
R584	T1265	T1264	pobj	melanoblasts,of
R585	T1266	T1265	prep	from,melanoblasts
R586	T1267	T1268	det	the,crest
R589	T1270	T1271	det	the,number
R590	T1271	T1254	dobj	number,affect
R591	T1272	T1271	cc	or,number
R592	T1273	T1271	conj	distribution,number
R593	T1274	T1271	prep	of,number
R594	T1275	T1276	compound	pigment,cells
R595	T1276	T1274	pobj	cells,of
R596	T1277	T1254	prep	in,affect
R597	T1278	T1279	det	the,skin
R598	T1279	T1277	pobj	skin,in
R599	T1280	T1281	punct	(,reviewed
R600	T1281	T1254	parataxis	reviewed,affect
R601	T1282	T1281	prep	in,reviewed
R602	T1283	T1282	pobj	Reedy,in
R603	T1284	T1285	advmod	et,al.
R604	T1285	T1283	advmod	al.,Reedy
R605	T1286	T1283	npadvmod	1998,Reedy
R606	T1287	T1281	punct	),reviewed
R607	T1288	T1254	punct	.,affect
R608	T1290	T1291	prep	Within,control
R609	T1292	T1293	compound	hair,follicles
R610	T1293	T1290	pobj	follicles,Within
R611	T1294	T1291	punct	", ",control
R612	T1295	T1296	amod	paracrine,signals
R613	T1296	T1291	nsubj	signals,control
R614	T1297	T1298	det	the,type
R615	T1298	T1291	dobj	type,control
R616	T1299	T1298	prep	of,type
R617	T1300	T1299	pobj	pigment,of
R618	T1301	T1298	acl	made,type
R619	T1302	T1301	prep	in,made
R620	T1303	T1304	amod	specific,regions
R621	T1304	T1302	pobj	regions,in
R622	T1305	T1304	prep	of,regions
R623	T1306	T1307	det	the,body
R624	T1307	T1305	pobj	body,of
R625	T1308	T1302	cc	or,in
R626	T1309	T1302	conj	at,in
R627	T1310	T1311	amod	specific,times
R628	T1311	T1309	pobj	times,at
R629	T1312	T1311	prep	during,times
R630	T1313	T1314	det	the,cycle
R633	T1316	T1317	punct	(,reviewed
R634	T1317	T1291	parataxis	reviewed,control
R635	T1318	T1317	prep	in,reviewed
R636	T1319	T1318	pobj	Furumura,in
R637	T1320	T1321	advmod	et,al.
R638	T1321	T1319	advmod	al.,Furumura
R639	T1322	T1319	npadvmod	1996,Furumura
R685	T1370	T1332	parataxis	reviewed,makes
R686	T1371	T1370	prep	in,reviewed
R687	T1372	T1371	pobj	Marks,in
R688	T1373	T1372	cc	and,Marks
R689	T1374	T1372	conj	Seabra,Marks
R690	T1375	T1372	npadvmod	2001,Marks
R691	T1376	T1370	punct	),reviewed
R692	T1377	T1332	punct	.,makes
R693	T1379	T1380	advmod	However,known
R694	T1381	T1380	punct	", ",known
R695	T1382	T1380	prep	for,known
R696	T1383	T1382	pobj	all,for
R697	T1384	T1383	prep	of,all
R698	T1385	T1386	det	these,mechanisms
R699	T1386	T1384	pobj	mechanisms,of
R700	T1387	T1383	punct	—,all
R701	T1388	T1389	amod	white,spotting
R702	T1389	T1383	appos	spotting,all
R703	T1390	T1389	punct	", ",spotting
R704	T1391	T1392	compound	pigment,type
R707	T1394	T1392	amod	switching,type
R708	T1395	T1392	punct	", ",type
R709	T1396	T1392	cc	and,type
R710	T1397	T1398	compound	melanosome,biogenesis
R711	T1398	T1392	conj	biogenesis,type
R712	T1399	T1380	punct	—,known
R713	T1400	T1380	nsubjpass	more,known
R714	T1401	T1380	auxpass	is,known
R715	T1402	T1380	prep	about,known
R716	T1403	T1404	det	the,identity
R717	T1404	T1402	pobj	identity,about
R718	T1405	T1404	prep	of,identity
R719	T1406	T1407	det	the,components
R722	T1409	T1380	prep	than,known
R723	T1410	T1411	poss	their,control
R728	T1415	T1380	punct	.,known
R729	T1417	T1418	nsubj	One,is
R730	T1419	T1417	prep	of,One
R731	T1420	T1421	det	the,aspects
R735	T1424	T1421	prep	of,aspects
R736	T1425	T1426	amod	regional,variation
R739	T1428	T1426	prep	in,variation
R740	T1429	T1428	pobj	vertebrates,in
R741	T1430	T1431	det	a,surface
R745	T1434	T1431	acl	juxtaposed,surface
R746	T1435	T1434	prep	to,juxtaposed
R747	T1436	T1437	det	a,surface
R751	T1440	T1418	punct	", ",is
R752	T1441	T1418	advcl	apparent,is
R753	T1442	T1441	prep	in,apparent
R754	T1443	T1444	det	the,color
R755	T1444	T1442	pobj	color,in
R756	T1445	T1444	prep	of,color
R757	T1446	T1445	pobj	skin,of
R758	T1447	T1446	punct	", ",skin
R759	T1448	T1446	conj	scales,skin
R760	T1449	T1448	punct	", ",scales
R761	T1450	T1448	conj	feathers,scales
R762	T1451	T1450	punct	", ",feathers
R763	T1452	T1450	cc	or,feathers
R764	T1453	T1450	conj	hair,feathers
R765	T1454	T1446	punct	", ",skin
R766	T1455	T1456	prep	in,is
R776	T1465	T1456	advmod	often,is
R777	T1466	T1456	acomp	sharp,is
R778	T1467	T1456	cc	and,is
R779	T1468	T1456	conj	lies,is
R780	T1469	T1468	prep	in,lies
R781	T1470	T1469	pobj	register,in
R782	T1471	T1470	prep	with,register
R783	T1472	T1473	det	the,limbs
R784	T1473	T1471	pobj	limbs,with
R785	T1474	T1418	punct	.,is
R786	T1476	T1477	prep	In,brought
R787	T1478	T1476	pobj	rodents,In
R788	T1479	T1478	cc	and,rodents
R789	T1480	T1481	advmod	probably,mammals
R792	T1483	T1477	punct	", ",brought
R793	T1484	T1485	det	this,difference
R796	T1487	T1485	prep	in,difference
R797	T1488	T1489	compound	hair,color

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T43	31-36	NCBITaxon:10088	denotes	Mouse
T44	37-41	UBERON:0010166	denotes	Coat
T45	45-50	PR:000016145	denotes	Tbx15
T46	121-127	NCBITaxon:33208	denotes	animal
T47	128-135	NCBITaxon:kingdom	denotes	kingdom
T48	144-148	UBERON:0010166	denotes	coat
T49	239-246	GO:0065007	denotes	control
T50	317-322	NCBITaxon:10088	denotes	mouse
T51	340-343	UBERON:0001690	denotes	ear
T52	417-424	GO:0065007	denotes	control
T53	432-438	PR:000004372	denotes	Agouti
T54	439-443	SO:0000704	denotes	gene
T55	445-449	NCBITaxon:10088	denotes	Mice
T56	463-469	PR:000004372	denotes	Agouti
T57	470-476	SO:0001023	denotes	allele
T58	548-552	UBERON:0001037	denotes	hair
T59	572-576	UBERON:0001037	denotes	hair
T60	753-757	SO:0000147	denotes	exon
T61	765-770	PR:000016145	denotes	Tbx15
T62	771-775	SO:0000704	denotes	gene
T63	783-792	UBERON:0000922	denotes	embryonic
T64	793-803	GO:0010467	denotes	expression
T65	818-828	UBERON:0003104	denotes	mesenchyme
T66	845-855	CHEBI:26130	denotes	pigmentary
T67	860-868	UBERON:0004288	denotes	skeletal
T68	903-910	NCBITaxon:33208	denotes	animals
T69	939-945	SO:0001023	denotes	allele
T70	949-954	PR:000016145	denotes	Tbx15
T71	1002-1007	PR:000016145	denotes	Tbx15
T72	1032-1041	UBERON:0000922	denotes	embryonic
T73	1042-1052	GO:0010467	denotes	expression
T74	1056-1061	PR:000016145	denotes	Tbx15
T75	1072-1082	UBERON:0003104	denotes	mesenchyme
T76	1103-1109	PR:000004372	denotes	Agouti
T77	1110-1120	GO:0010467	denotes	expression
T78	1124-1142	UBERON:2000164	denotes	ventral mesenchyme
T79	1162-1167	PR:000016145	denotes	Tbx15
T80	1169-1179	GO:0010467	denotes	expression
T81	1183-1189	PR:000004372	denotes	Agouti
T82	1198-1205	UBERON:0000922	denotes	embryos
T83	1214-1219	GO:0007567	denotes	natal
T84	1220-1227	NCBITaxon:33208	denotes	animals
T85	1426-1441	UBERON:0019248	denotes	early embryonic
T86	1442-1452	GO:0010467	denotes	expression
T87	1456-1461	PR:000016145	denotes	Tbx15
T88	1631-1635	UBERON:0002101	denotes	limb
T89	1659-1668	UBERON:0000922	denotes	Embryonic
T90	1669-1679	GO:0010467	denotes	expression
T91	1683-1688	PR:000016145	denotes	Tbx15
T92	1705-1715	UBERON:0003104	denotes	mesenchyme
T93	1809-1815	UBERON:0002067	denotes	dermis
T94	1865-1869	SO:0000704	denotes	gene
T95	1880-1889	UBERON:0000922	denotes	embryonic
T96	1880-1901	GO:0009790	denotes	embryonic development
T97	2010-2017	NCBITaxon:40674	denotes	mammals
T639	2357-2367	NCBITaxon:7742	denotes	vertebrate
T640	2553-2560	NCBITaxon:33208	denotes	animals
T641	2645-2652	GO:0065007	denotes	control
T642	2712-2723	NCBITaxon:7742	denotes	vertebrates
T643	2763-2780	UBERON:0004765	denotes	skeletal elements
T644	2804-2813	UBERON:0007376	denotes	epidermal
T645	2814-2824	UBERON:0004529	denotes	appendages
T646	2843-2850	CHEBI:26130	denotes	pigment
T647	2922-2928	NCBITaxon:33208	denotes	animal
T648	2956-2963	CHEBI:26130	denotes	pigment
T649	3097-3104	NCBITaxon:species	denotes	species
T650	3123-3130	NCBITaxon:33208	denotes	animals
T651	3152-3159	NCBITaxon:species	denotes	species
T652	3304-3311	CHEBI:26130	denotes	pigment
T653	3490-3500	NCBITaxon:7742	denotes	vertebrate
T654	3572-3582	CHEBI:26130	denotes	pigmentary
T655	3661-3666	UBERON:0000062	denotes	organ
T656	3783-3793	NCBITaxon:7742	denotes	vertebrate
T657	3815-3821	UBERON:0000922	denotes	embryo
T658	3872-3884	CL:0000541	denotes	melanoblasts
T659	3894-3906	UBERON:0002342	denotes	neural crest
T660	3944-3951	CHEBI:26130	denotes	pigment
T661	3944-3957	CL:0000147	denotes	pigment cells
T662	4010-4024	UBERON:0002073	denotes	hair follicles
T663	4026-4035	GO:0038001	denotes	paracrine
T664	4044-4051	GO:0065007	denotes	control
T665	4064-4071	CHEBI:26130	denotes	pigment
T666	4141-4145	UBERON:0001037	denotes	hair
T667	4141-4151	GO:0042633	denotes	hair cycle
T668	4216-4244	GO:0051904	denotes	movement of pigment granules
T669	4228-4235	CHEBI:26130	denotes	pigment
T670	4228-4244	GO:0048770	denotes	pigment granules
T671	4252-4263	CL:0000148	denotes	melanocytes
T672	4272-4283	CL:0000148	denotes	melanocytes
T673	4287-4300	CL:0000312	denotes	keratinocytes
T674	4517-4524	CHEBI:26130	denotes	pigment
T675	4545-4555	GO:0042470	denotes	melanosome
T676	4545-4566	GO:1903232	denotes	melanosome biogenesis
T677	4660-4667	GO:0065007	denotes	control
T678	4732-4743	NCBITaxon:7742	denotes	vertebrates
T679	4839-4845	UBERON:0002542	denotes	scales
T680	4847-4855	UBERON:0000022	denotes	feathers
T681	4860-4864	UBERON:0001037	denotes	hair
T682	4973-4978	UBERON:0002101	denotes	limbs
T683	4983-4990	NCBITaxon:9989	denotes	rodents
T684	5010-5017	NCBITaxon:40674	denotes	mammals
T685	5051-5055	UBERON:0001037	denotes	hair
T686	5097-5104	CHEBI:26130	denotes	pigment
T687	5127-5134	SO:0001023	denotes	allelic
T688	5152-5158	PR:000004372	denotes	Agouti
T689	5159-5163	SO:0000704	denotes	gene
T690	5207-5215	GO:0046903	denotes	Secreted
T691	5219-5233	UBERON:0000412	denotes	dermal papilla
T692	5219-5239	CL:0000346	denotes	dermal papilla cells
T693	5252-5265	UBERON:0002073	denotes	hair follicle
T694	5288-5294	PR:000004372	denotes	Agouti
T695	5310-5321	CL:0000148	denotes	melanocytes
T696	5384-5393	CHEBI:24009	denotes	eumelanin
T697	5408-5419	CHEBI:81393	denotes	pheomelanin
T698	5421-5427	PR:000004372	denotes	Agouti
T699	5538-5542	UBERON:0001037	denotes	hair
T700	5538-5548	GO:0042633	denotes	hair cycle
T701	5630-5639	GO:0065007	denotes	regulated
T702	5640-5650	GO:0010467	denotes	expression
T703	5731-5735	NCBITaxon:10088	denotes	mice
T704	5768-5774	SO:0001023	denotes	allele
T705	5794-5802	UBERON:2002284	denotes	markings
T706	5814-5818	UBERON:0002387	denotes	feet
T707	5820-5824	UBERON:0001690	denotes	ears
T708	5829-5833	UBERON:0000033	denotes	head
T709	5855-5859	UBERON:0000033	denotes	head
T710	5860-5865	UBERON:2002283	denotes	spots
T711	5878-5881	NCBITaxon:9615	denotes	dog
T712	5904-5908	NCBITaxon:10088	denotes	mice
T713	5980-5986	PR:000004372	denotes	Agouti
T714	5992-6000	SO:0001060	denotes	isoforms
T715	6032-6063	SO:0000315	denotes	transcriptional initiation site
T716	6068-6089	SO:0000445	denotes	5′ untranslated exons
T717	6073-6083	GO:0006412	denotes	translated
T718	6094-6098	UBERON:0001037	denotes	hair
T719	6094-6104	GO:0042633	denotes	hair cycle
T720	6115-6125	SO:0000673	denotes	transcript
T721	6129-6138	GO:0010467	denotes	expressed
T722	6197-6201	UBERON:0001037	denotes	hair
T723	6237-6247	SO:0000673	denotes	transcript
T724	6251-6260	GO:0010467	denotes	expressed
T725	6300-6304	UBERON:0001037	denotes	hair
T726	6383-6390	NCBITaxon:33208	denotes	Animals
T727	6407-6413	SO:0001023	denotes	allele
T728	6414-6421	GO:0010467	denotes	express
T729	6448-6454	PR:000004372	denotes	Agouti
T730	6455-6465	SO:0000673	denotes	transcript
T731	6532-6537	UBERON:0001037	denotes	hairs
T732	6574-6579	UBERON:0001037	denotes	hairs
T733	6623-6627	UBERON:0002101	denotes	limb
T734	6628-6637	UBERON:0000309	denotes	body wall
T735	6638-6651	UBERON:0004905	denotes	articulations
T736	6677-6684	UBERON:0006378	denotes	whisker
T737	6685-6688	UBERON:2001977	denotes	pad
T738	6707-6713	PR:000004372	denotes	Agouti
T739	6714-6722	SO:0001060	denotes	isoforms
T740	6732-6741	GO:0010467	denotes	expressed
T741	6766-6775	UBERON:0000922	denotes	embryonic
T742	6827-6834	CHEBI:26130	denotes	pigment
T743	6827-6839	CL:0000147	denotes	pigment cell
T744	6835-6855	GO:0030154	denotes	cell differentiation
T745	6884-6894	GO:0065007	denotes	regulatory
T746	6884-6903	SO:0005836	denotes	regulatory elements
T747	6925-6931	PR:000004372	denotes	Agouti
T748	6932-6940	SO:0001060	denotes	isoforms
T749	7007-7013	UBERON:0000922	denotes	embryo
T750	7046-7051	GO:0007567	denotes	birth
T751	7121-7125	NCBITaxon:10088	denotes	mice
T752	7207-7214	NCBITaxon:40674	denotes	mammals
T753	7220-7233	GO:0009653	denotes	morphogenetic
T754	7332-7339	CHEBI:26130	denotes	pigment
T755	7348-7361	UBERON:0002073	denotes	hair follicle
T756	7348-7373	CL:0002483	denotes	hair follicle melanocytes
T757	7390-7396	UBERON:0002067	denotes	dermis
T758	7404-7409	UBERON:0000180	denotes	flank
T759	7445-7455	UBERON:0004016	denotes	dermatomal
T760	7471-7478	UBERON:0002329	denotes	somites
T761	7483-7499	UBERON:0007529	denotes	loose mesenchyme
T762	7517-7539	UBERON:0003081	denotes	lateral plate mesoderm
T763	7781-7786	UBERON:0007023	denotes	adult
T764	8024-8029	NCBITaxon:10088	denotes	mouse
T2336	9483-9487	UBERON:0001037	denotes	hair
T2337	9614-9618	UBERON:0001037	denotes	hair
T2338	9643-9647	UBERON:0001037	denotes	hair
T2339	9799-9806	CHEBI:26130	denotes	pigment
T2340	9799-9812	CL:0000147	denotes	pigment cells
T2341	9837-9844	CHEBI:26130	denotes	pigment
T2342	9872-9882	GO:0010467	denotes	expression
T2343	9886-9892	PR:000004372	denotes	Agouti
T2344	9917-9921	UBERON:0001037	denotes	hair
T2345	9931-9938	NCBITaxon:33208	denotes	animals
T2346	10150-10154	NCBITaxon:10088	denotes	mice
T2347	10168-10174	PR:000004372	denotes	Agouti
T2348	10219-10223	UBERON:0001037	denotes	hair
T2349	10345-10352	CHEBI:26130	denotes	pigment
T2350	10375-10379	NCBITaxon:10088	denotes	mice
T2351	10425-10429	UBERON:0001037	denotes	hair
T2352	10440-10444	UBERON:0001037	denotes	hair
T2353	10505-10511	UBERON:0001137	denotes	dorsum
T2354	10515-10522	UBERON:0013235	denotes	ventrum
T2355	10536-10541	UBERON:0000180	denotes	flank
T2356	10542-10547	UBERON:0001037	denotes	hairs
T2357	10559-10563	NCBITaxon:10088	denotes	mice
T2358	10627-10638	CHEBI:81393	denotes	pheomelanin
T2359	10694-10698	UBERON:0001037	denotes	hair
T2360	10738-10742	UBERON:0001037	denotes	hair
T2361	10820-10826	PR:000004372	denotes	Agouti
T2362	10846-10850	UBERON:0001037	denotes	hair
T2363	10846-10856	GO:0042633	denotes	hair-cycle
T2364	10925-10929	UBERON:0001037	denotes	hair
T2365	10941-10945	NCBITaxon:10088	denotes	mice
T2366	11059-11063	UBERON:0001037	denotes	hair
T2367	11075-11082	NCBITaxon:33208	denotes	animals
T2368	11111-11117	PR:000004372	denotes	Agouti
T2369	11262-11266	UBERON:0001037	denotes	hair
T2370	11349-11353	UBERON:0001037	denotes	hair
T2371	11349-11360	GO:0042633	denotes	hair cycles
T2372	11383-11387	UBERON:0001037	denotes	hair
T2373	11431-11438	CHEBI:26130	denotes	pigment
T2374	11464-11468	NCBITaxon:10088	denotes	mice
T2375	12703-12708	GO:0007567	denotes	natal
T2376	12739-12753	UBERON:0002073	denotes	hair follicles
T2377	12802-12816	UBERON:0002073	denotes	hair follicles
T2378	13029-13033	UBERON:0001037	denotes	hair
T2379	13059-13064	UBERON:0001137	denotes	dorsa
T2380	13069-13075	UBERON:0013235	denotes	ventra
T2381	13079-13084	UBERON:0007023	denotes	adult
T2382	13085-13089	NCBITaxon:10088	denotes	mice
T2383	13113-13117	NCBITaxon:10088	denotes	mice
T2384	13174-13179	UBERON:0001037	denotes	hairs
T2385	13181-13188	UBERON:0010513	denotes	zigzags
T2386	13202-13207	UBERON:0001037	denotes	hairs
T2387	13209-13217	UBERON:0010510	denotes	auchenes
T2388	13219-13223	UBERON:0010511	denotes	awls
T2389	13229-13240	UBERON:0010512	denotes	guard hairs
T2390	13245-13251	UBERON:0001137	denotes	dorsum
T2391	13264-13271	UBERON:0013235	denotes	ventrum
T2392	13327-13331	UBERON:0001037	denotes	hair
T2393	13362-13366	NCBITaxon:10088	denotes	mice
T2394	13446-13450	NCBITaxon:10088	denotes	mice
T2395	13477-13484	CHEBI:26130	denotes	pigment
T2396	13529-13539	GO:0010467	denotes	expression
T2397	13543-13549	PR:000004372	denotes	Agouti
T2398	13555-13562	NCBITaxon:33208	denotes	animals
T2399	13585-13591	SO:0001023	denotes	allele
T2400	13595-13601	PR:000004372	denotes	Agouti
T2401	13640-13645	UBERON:0001037	denotes	hairs
T2402	13664-13671	CHEBI:25179	denotes	melanin
T2403	13684-13689	UBERON:0001037	denotes	hairs
T2404	13741-13745	UBERON:0010166	denotes	coat
T2405	13765-13769	CHEBI:49168	denotes	DOPA
T2406	13877-13883	UBERON:0002067	denotes	dermis
T2407	13913-13917	NCBITaxon:10088	denotes	mice
T2408	13960-13964	NCBITaxon:10088	denotes	mice
T2409	14009-14013	CHEBI:49168	denotes	DOPA
T2410	14080-14087	CHEBI:25179	denotes	melanin
T2411	14109-14113	NCBITaxon:10088	denotes	mice
T2412	14168-14174	PR:000004372	denotes	Agouti
T2413	14176-14183	CHEBI:25179	denotes	Melanin
T2414	14206-14211	UBERON:0001037	denotes	hairs
T2415	14261-14268	CHEBI:26130	denotes	pigment
T2416	14261-14274	CL:0000147	denotes	pigment cells
T2417	14349-14353	UBERON:0001037	denotes	hair
T2418	14354-14361	CHEBI:26130	denotes	pigment
T2419	14379-14383	NCBITaxon:10088	denotes	mice
T2420	14412-14416	UBERON:0001037	denotes	hair
T2421	14412-14423	GO:0042633	denotes	hair cycles
T2422	14429-14438	UBERON:0000113	denotes	adulthood
T2423	14451-14455	UBERON:0001037	denotes	hair
T2424	14582-14589	CHEBI:26130	denotes	pigment
T2425	14619-14625	PR:000004372	denotes	Agouti
T2426	14652-14656	UBERON:0001037	denotes	hair
T2427	14684-14691	CHEBI:25179	denotes	melanin
T3347	14750-14753	UBERON:0001690	denotes	ear
T3348	14822-14825	UBERON:0001690	denotes	ear
T3349	14853-14858	NCBITaxon:10088	denotes	mouse
T3350	14886-14892	SO:0001023	denotes	allele
T3351	15177-15184	NCBITaxon:33208	denotes	animals
T3352	15210-15214	UBERON:0000970	denotes	eyes
T3353	15222-15240	UBERON:0001819	denotes	palpebral fissures
T3354	15250-15255	UBERON:0000004	denotes	nasal
T3355	15278-15283	UBERON:0003129	denotes	skull
T3356	15385-15389	UBERON:0001690	denotes	ears
T3357	15422-15425	UBERON:0001690	denotes	ear
T3358	15447-15453	SO:0001023	denotes	allele
T3359	15478-15485	CHEBI:26130	denotes	pigment
T3360	15568-15575	SO:0000704	denotes	genetic
T3361	15595-15596	PR:000004372	denotes	A
T3362	15616-15621	UBERON:0000916	denotes	belly
T3363	15622-15626	UBERON:0001037	denotes	hair
T3364	15650-15654	UBERON:0011270	denotes	back
T3365	15655-15659	UBERON:0001037	denotes	hair
T3366	15665-15670	UBERON:0000916	denotes	belly
T3367	15671-15675	UBERON:0001037	denotes	hair
T3368	15725-15729	UBERON:0001456	denotes	face
T3369	15770-15777	CHEBI:26130	denotes	pigment
T3370	15824-15828	NCBITaxon:10088	denotes	mice
T3371	15858-15865	NCBITaxon:33208	denotes	animals
T3372	15994-15999	UBERON:0001037	denotes	hairs
T3373	16073-16077	UBERON:0002101	denotes	limb
T3374	16078-16087	UBERON:0000309	denotes	body wall
T3375	16224-16228	NCBITaxon:10088	denotes	mice
T3376	16265-16270	UBERON:0001037	denotes	hairs
T3377	16316-16320	NCBITaxon:10088	denotes	mice
T3378	16366-16372	UBERON:2001463	denotes	stripe
T3379	16383-16388	UBERON:0000180	denotes	flank
T3380	16412-16416	NCBITaxon:10088	denotes	mice
T3381	16503-16508	UBERON:0000180	denotes	flank
T3382	16523-16532	CHEBI:24009	denotes	eumelanic
T3383	16657-16664	NCBITaxon:33208	denotes	animals
T3384	16748-16755	NCBITaxon:33208	denotes	animals
T3385	16947-16954	NCBITaxon:33208	denotes	animals
T3386	17047-17052	UBERON:0002101	denotes	limbs
T3387	17061-17068	UBERON:1000019	denotes	cranium
T3388	17082-17089	UBERON:0006378	denotes	whisker
T3389	17090-17093	UBERON:2001977	denotes	pad
T3390	18536-18543	CHEBI:26130	denotes	pigment
T3391	18587-18591	UBERON:0001037	denotes	hair
T3392	18696-18700	UBERON:0001037	denotes	hair
T3393	18716-18722	UBERON:0001137	denotes	dorsum
T3394	18727-18734	UBERON:0013235	denotes	ventrum
T3395	18762-18769	NCBITaxon:33208	denotes	animals
T3396	18817-18821	UBERON:0001037	denotes	hair
T3397	18902-18909	NCBITaxon:33208	denotes	animals
T3398	18942-18950	UBERON:0004288	denotes	skeletal
T3399	18981-18985	UBERON:0010166	denotes	coat
T3400	19119-19124	GO:0007567	denotes	birth
T3401	19158-19169	GO:0042438	denotes	melanogenic
T3402	19234-19245	CL:0000541	denotes	melanoblast
T3403	19265-19277	UBERON:0002342	denotes	neural crest
T3404	19338-19348	CL:0000148	denotes	melanocyte
T3405	19369-19376	CHEBI:26130	denotes	pigment
T3406	19369-19386	GO:0046148	denotes	pigment synthesis
T3407	19454-19460	UBERON:0001137	denotes	dorsum
T3408	19498-19505	_FRAGMENT	denotes	area of
T3409	19511-19515	UBERON:0000014	denotes	skin
T3410	19559-19564	UBERON:0002101	denotes	limbs
T3411	19602-19611	CHEBI:24009	denotes	eumelanin
T3412	19630-19635	UBERON:0007023	denotes	adult
T3413	19636-19643	NCBITaxon:33208	denotes	animals
T3414	19717-19757	GO:0009953	denotes	establishment of dorsoventral patterning
T3415	19765-19781	GO:0043588	denotes	skin development
T3416	19951-19961	CL:0000148	denotes	melanocyte
T3417	19992-20003	CHEBI:81393	denotes	pheomelanin
T3418	20059-20063	UBERON:0001037	denotes	hair
T3419	20076-20083	UBERON:0013235	denotes	ventrum
T3420	20087-20093	UBERON:0001137	denotes	dorsum
T3421	20119-20123	SO:0000704	denotes	gene
T3422	20142-20147	PR:000016145	denotes	Tbx15
T3423	20161-20170	GO:0010467	denotes	expressed
T4427	20392-20395	UBERON:0001690	denotes	ear
T4428	20396-20402	SO:0001023	denotes	allele
T4429	20414-20420	SO:0001023	denotes	allele
T4430	20648-20652	NCBITaxon:10088	denotes	mice
T4431	20765-20774	NCBITaxon:2	denotes	bacterial
T4432	20765-20796	SO:0000153	denotes	bacterial artificial chromosome
T4433	20798-20801	SO:0000153	denotes	BAC
T4434	20803-20809	SO:0000149	denotes	contig
T4435	20873-20878	SO:0000704	denotes	genes
T4436	20890-20895	PR:000016145	denotes	Tbx15
T4437	20923-20928	PR:000016145	denotes	Tbx15
T4438	20963-20971	UBERON:0004288	denotes	skeletal
T4439	21062-21071	UBERON:0000922	denotes	embryonic
T4440	21072-21082	GO:0010467	denotes	expression
T4441	21125-21130	UBERON:0002101	denotes	limbs
T4442	22149-22154	NCBITaxon:10088	denotes	mouse
T4443	22155-22161	SO:0001026	denotes	genome
T4444	22186-22197	_FRAGMENT	denotes	portions of
T4445	22212-22217	SO:0000852	denotes	exons
T4446	22206-22211	PR:000016145	denotes	Tbx15
T4447	22254-22261	SO:0001026	denotes	genomic
T4448	22276-22280	SO:0000704	denotes	gene
T4449	22310-22314	PR:000016145	denotes	Tbx8
T4450	22360-22365	PR:000016145	denotes	Tbx14
T4451	22407-22417	NCBITaxon:7742	denotes	vertebrate
T4452	22418-22425	SO:0001026	denotes	genomes
T4453	22429-22434	PR:000016145	denotes	Tbx15
T4454	22559-22566	SO:0001026	denotes	genomic
T4455	22593-22598	NCBITaxon:10088	denotes	mouse
T4456	22599-22605	SO:0001026	denotes	genome
T4457	22666-22671	PR:000016145	denotes	Tbx15
T4458	22672-22678	SO:0000188	denotes	intron
T4459	22709-22724	GO:0043631	denotes	polyadenylation
T4460	22709-22733	SO:0000610	denotes	polyadenylation sequence
T4461	22761-22780	CHEBI:17369	denotes	mannose-6-phosphate
T4462	22790-22800	SO:0000336	denotes	pseudogene
T4463	22807-22809	SO:0000336	denotes	ps
T4464	22902-22912	SO:0000673	denotes	transcript
T4465	23032-23037	PR:000016145	denotes	Tbx15
T4466	23071-23077	SO:0000417	denotes	domain
T4467	23086-23093	NCBITaxon:33208	denotes	animals
T4468	23143-23150	NCBITaxon:33208	denotes	animals
T4469	23199-23205	SO:0001023	denotes	allele
T4470	23236-23238	SO:0000336	denotes	ps
T4471	23249-23254	SO:0000704	denotes	genes
T4472	23258-23269	SO:0000673	denotes	transcripts
T4473	23419-23424	PR:000016145	denotes	Tbx15
T4474	23428-23432	SO:0000704	denotes	gene
T4475	23446-23455	UBERON:0000922	denotes	embryonic
T4476	23446-23466	CL:0002322	denotes	embryonic stem cells
T4477	23481-23487	SO:0001023	denotes	allele
T4478	23489-23494	PR:000016145	denotes	Tbx15
T4479	23494-23498	PR:000033987	denotes	LacZ
T4480	23511-23515	SO:0000243	denotes	IRES
T4481	23516-23520	PR:000033987	denotes	LacZ
T4482	23530-23538	SO:0005853	denotes	cassette
T4483	23557-23575	SO:0000236	denotes	open reading frame
T4484	23579-23584	SO:0000360	denotes	codon
T4485	23608-23614	SO:0000417	denotes	domain
T4486	23628-23635	NCBITaxon:33208	denotes	Animals
T4487	23666-23672	SO:0001023	denotes	allele
T4488	23716-23724	UBERON:0004288	denotes	skeletal
T4489	23741-23745	UBERON:0001037	denotes	hair
T4490	23770-23775	PR:000016145	denotes	Tbx15
T4491	23775-23779	PR:000033987	denotes	LacZ
T4492	23780-23785	PR:000016145	denotes	Tbx15
T4493	23785-23789	PR:000033987	denotes	LacZ
T4494	23928-23933	PR:000016145	denotes	Tbx15
T4495	23933-23937	PR:000033987	denotes	LacZ
T4496	23996-24003	NCBITaxon:33208	denotes	animals
T4497	24095-24100	UBERON:0000180	denotes	flank
T4498	24137-24144	NCBITaxon:33208	denotes	animals
T4499	24201-24211	CHEBI:26130	denotes	pigmentary
T4500	24287-24292	PR:000016145	denotes	Tbx15
T5281	24309-24314	PR:000016145	denotes	Tbx15
T5282	24319-24325	PR:000004372	denotes	Agouti
T5283	24394-24407	GO:0097617	denotes	hybridization
T5284	24418-24428	GO:0010467	denotes	expression
T5285	24432-24437	PR:000016145	denotes	Tbx15
T5286	24473-24482	UBERON:0004347	denotes	limb buds
T5287	24503-24519	UBERON:0002539	denotes	branchial arches
T5288	24521-24527	UBERON:0000180	denotes	flanks
T5289	24616-24626	GO:0097617	denotes	hybridized
T5290	24629-24634	PR:000016145	denotes	Tbx15
T5291	24703-24713	GO:0010467	denotes	expression
T5292	24726-24748	_FRAGMENT	denotes	mesenchymal tissues of
T5293	24753-24757	UBERON:0005253	denotes	head
T5294	24759-24764	UBERON:0005256	denotes	trunk
T5295	24781-24786	UBERON:0009749	denotes	limbs
T5296	24837-24842	UBERON:0003129	denotes	skull
T5297	24844-24862	UBERON:0002413	denotes	cervical vertebrae
T5298	24868-24872	UBERON:0002101	denotes	limb
T5299	24900-24904	NCBITaxon:10088	denotes	mice
T5300	24934-24937	UBERON:0001690	denotes	ear
T5301	24938-24944	SO:0001023	denotes	allele
T5302	25809-25818	UBERON:0000922	denotes	embryonic
T5303	25819-25824	UBERON:0000180	denotes	flank
T5304	25825-25835	GO:0010467	denotes	expression
T5305	25891-25895	NCBITaxon:10088	denotes	mice
T5306	25908-25917	UBERON:0000916	denotes	abdominal
T5307	25997-26007	GO:0010467	denotes	expression
T5308	26027-26037	UBERON:0003104	denotes	mesenchyme
T5309	26154-26160	UBERON:0002067	denotes	dermis
T5310	26191-26207	UBERON:0007529	denotes	loose mesenchyme
T5311	26226-26238	UBERON:0018260	denotes	muscle layer
T5312	26240-26245	PR:000016145	denotes	Tbx15
T5313	26249-26258	GO:0010467	denotes	expressed
T5314	26308-26325	UBERON:0002378	denotes	abdominal muscles
T5315	26341-26346	PR:000016145	denotes	Tbx15
T5316	26350-26359	GO:0010467	denotes	expressed
T5317	26430-26436	UBERON:0002067	denotes	dermis
T5318	26459-26466	UBERON:0005933	denotes	sheaths
T5319	26470-26484	UBERON:0002073	denotes	hair follicles
T5320	26492-26502	GO:0010467	denotes	expression
T5321	26532-26547	UBERON:0000412	denotes	dermal papillae
T5322	26532-26553	CL:0000346	denotes	dermal papillae cells
T5323	26591-26597	PR:000004372	denotes	Agouti
T5324	26601-26608	CHEBI:26130	denotes	pigment
T5325	26641-26646	GO:0007567	denotes	natal
T5326	26647-26651	UBERON:0001037	denotes	hair
T5327	26681-26688	SO:0001060	denotes	isoform
T5328	26692-26698	PR:000004372	denotes	Agouti
T5329	26702-26711	GO:0010467	denotes	expressed
T5330	26781-26791	GO:0097617	denotes	hybridized
T5331	26808-26813	PR:000016145	denotes	Tbx15
T5332	26818-26824	PR:000004372	denotes	Agouti
T5333	26876-26886	GO:0010467	denotes	expression
T5334	26890-26896	PR:000004372	denotes	Agouti
T5335	26917-26927	GO:0010467	denotes	expression
T5336	26931-26936	PR:000016145	denotes	Tbx15
T5337	26993-27003	GO:0010467	denotes	expression
T5338	27041-27046	PR:000016145	denotes	Tbx15
T5339	27047-27057	GO:0010467	denotes	expression
T5340	27106-27112	PR:000004372	denotes	Agouti
T5341	27113-27123	GO:0010467	denotes	expression
T5342	27689-27699	GO:0010467	denotes	expression
T5343	27703-27709	PR:000004372	denotes	Agouti
T5344	27859-27865	PR:000004372	denotes	Agouti
T5345	27866-27876	GO:0010467	denotes	expression
T5346	27921-27928	UBERON:0000922	denotes	embryos
T5347	27956-27966	GO:0010467	denotes	expression
T5348	27970-27976	PR:000004372	denotes	Agouti
T5349	28014-28021	NCBITaxon:33208	denotes	animals
T5350	28083-28089	UBERON:0002067	denotes	dermis
T5351	28094-28109	UBERON:0000412	denotes	dermal papillae
T5352	28094-28115	CL:0000346	denotes	dermal papillae cells
T5353	28179-28183	NCBITaxon:10088	denotes	mice
T5354	28243-28249	PR:000004372	denotes	Agouti
T5355	28250-28260	GO:0010467	denotes	expression
T5356	28267-28272	GO:0007567	denotes	birth
T5357	28284-28294	GO:0010467	denotes	expression
T5358	28298-28303	PR:000016145	denotes	Tbx15
T5359	28308-28314	PR:000004372	denotes	Agouti
T5360	28394-28399	PR:000016145	denotes	Tbx15
T5361	28414-28424	GO:0010467	denotes	expression
T5362	28428-28434	PR:000004372	denotes	Agouti
T6028	29105-29114	UBERON:0000922	denotes	Embryonic
T6029	29115-29120	PR:000016145	denotes	Tbx15
T6030	29121-29131	GO:0010467	denotes	Expression
T6031	29255-29265	GO:0010467	denotes	expression
T6032	29269-29274	PR:000016145	denotes	Tbx15
T6033	29282-29291	UBERON:0000922	denotes	embryonic
T6034	29299-29304	UBERON:0000180	denotes	flank
T6035	29364-29370	UBERON:0002067	denotes	dermis
T6036	29397-29404	CHEBI:26130	denotes	pigment
T6037	29451-29457	PR:000004372	denotes	Agouti
T6038	29458-29465	SO:0001060	denotes	isoform
T6039	29569-29578	UBERON:0000922	denotes	embryonic
T6040	29654-29663	UBERON:0000922	denotes	embryonic
T6041	29725-29729	UBERON:0001037	denotes	hair
T6042	29751-29761	GO:0010467	denotes	expression
T6043	29765-29770	PR:000016145	denotes	Tbx15
T6044	29775-29781	PR:000004372	denotes	Agouti
T6045	29907-29914	UBERON:0000922	denotes	embryos
T6046	29946-29950	UBERON:0001037	denotes	hair
T6047	29989-29995	UBERON:0000473	denotes	testis
T6048	30058-30067	UBERON:0007376	denotes	epidermal
T6049	30171-30180	UBERON:0000922	denotes	embryonic
T6050	30181-30187	UBERON:0002067	denotes	dermis
T6051	30235-30244	UBERON:0000922	denotes	embryonic
T6052	30260-30267	UBERON:0000922	denotes	embryos
T6053	30281-30286	UBERON:0000180	denotes	flank
T6054	30391-30395	UBERON:0001037	denotes	hair
T6055	30402-30408	UBERON:0000473	denotes	testis
T6056	30448-30452	SO:0000704	denotes	gene
T6057	30448-30463	GO:0010467	denotes	gene expression
T6058	30478-30491	GO:0097617	denotes	hybridization
T6059	30561-30566	UBERON:0000180	denotes	flank
T6060	30645-30650	UBERON:0000180	denotes	flank
T6061	30675-30685	UBERON:0000924	denotes	ectodermal
T6062	30749-30756	UBERON:0003082	denotes	myotome
T6063	31648-31657	UBERON:0000922	denotes	embryonic
T6064	31690-31694	UBERON:0001037	denotes	hair
T6065	31720-31726	UBERON:0000473	denotes	testis
T6066	31756-31760	UBERON:0001037	denotes	hair
T6067	31795-31799	UBERON:0001037	denotes	hair
T6068	31844-31848	UBERON:0001037	denotes	hair
T6069	31877-31882	UBERON:0000180	denotes	flank
T6070	31919-31923	UBERON:0001037	denotes	hair
T6071	31960-31964	UBERON:0001037	denotes	hair
T6072	32025-32030	UBERON:0000180	denotes	flank
T6073	32070-32074	UBERON:0001037	denotes	hair
T6074	32136-32141	UBERON:0001037	denotes	hairs
T6075	32183-32189	UBERON:0000479	denotes	tissue
T6076	32236-32245	GO:0010467	denotes	expressed
T6077	32246-32251	PR:000016145	denotes	Tbx15
T6078	32260-32266	PR:000004372	denotes	Agouti
T6079	32274-32279	UBERON:0000180	denotes	flank
T6080	32287-32296	GO:0010467	denotes	expressed
T6081	32302-32307	SO:0000704	denotes	genes
T6082	32417-32427	GO:0010467	denotes	expression
T6083	32449-32454	PR:000016145	denotes	Tbx15
T6084	32459-32465	PR:000004372	denotes	Agouti
T6085	32555-32571	GO:0043588	denotes	skin development
T6086	32585-32595	GO:0010467	denotes	expression
T6087	32599-32604	PR:000016145	denotes	Tbx15
T6728	32691-32698	CHEBI:26130	denotes	Pigment
T6729	32748-32764	UBERON:0015178	denotes	Somitic Frontier
T6730	32769-32779	UBERON:0000924	denotes	ectodermal
T6731	32828-32837	UBERON:0000922	denotes	embryonic
T6732	32838-32844	UBERON:0001137	denotes	dorsum
T6733	32849-32858	UBERON:0000922	denotes	embryonic
T6734	32859-32864	UBERON:0000180	denotes	flank
T6735	32896-32906	NCBITaxon:7742	denotes	vertebrate
T6736	32907-32914	UBERON:0000922	denotes	embryos
T6737	33029-33035	UBERON:0002067	denotes	dermis
T6738	33049-33065	UBERON:0003077	denotes	somitic mesoderm
T6739	33070-33076	UBERON:0002067	denotes	dermis
T6740	33090-33112	UBERON:0003081	denotes	lateral plate mesoderm
T6741	33146-33162	UBERON:0015178	denotes	somitic frontier
T6742	33318-33327	NCBITaxon:40674	denotes	mammalian
T6743	33328-33335	UBERON:0000922	denotes	embryos
T6744	33337-33343	UBERON:0002329	denotes	somite
T6745	33349-33362	UBERON:0003081	denotes	lateral plate
T6746	33371-33379	UBERON:0000926	denotes	mesoderm
T6747	33414-33420	UBERON:0002067	denotes	dermis
T6748	33447-33451	UBERON:0002101	denotes	limb
T6749	33452-33461	UBERON:0000309	denotes	body wall
T6750	33596-33606	UBERON:0000924	denotes	ectodermal
T6751	33704-33710	UBERON:0002067	denotes	dermis
T6752	33724-33746	UBERON:0003081	denotes	lateral plate mesoderm
T6753	33769-33778	SO:0000902	denotes	transgene
T6754	33793-33798	PR:000008703	denotes	Hoxb6
T6755	33799-33807	SO:0000167	denotes	promoter
T6756	33910-33919	GO:0007565	denotes	gestation
T6757	33920-33927	UBERON:0000922	denotes	embryos
T6758	33946-33951	PR:000008703	denotes	Hoxb6
T6759	33956-33965	SO:0000902	denotes	transgene
T6760	33979-33983	PR:000033987	denotes	lacZ
T6761	33993-33997	SO:0000704	denotes	gene
T6762	34021-34026	CHEBI:75055	denotes	X-Gal
T6763	34039-34061	UBERON:0003081	denotes	lateral plate mesoderm
T6764	34070-34093	UBERON:0003077	denotes	somite-derived mesoderm
T6765	34101-34106	UBERON:0002100	denotes	trunk
T6766	34168-34175	NCBITaxon:33208	denotes	animals
T6767	34212-34217	CHEBI:75055	denotes	X-Gal
T6768	34244-34257	UBERON:0003081	denotes	lateral plate
T6769	34266-34272	UBERON:0002067	denotes	dermis
T6770	34380-34384	NCBITaxon:10088	denotes	mice
T6771	34398-34409	CHEBI:81393	denotes	pheomelanin
T6772	34539-34548	CHEBI:24009	denotes	eumelanin
T6773	34553-34559	UBERON:0002329	denotes	somite
T6774	34568-34574	UBERON:0002067	denotes	dermis
T6775	34740-34753	UBERON:0003081	denotes	lateral plate
T6776	34759-34765	UBERON:0002329	denotes	somite
T6777	34774-34780	UBERON:0002067	denotes	dermis
T6778	35878-35882	UBERON:0002101	denotes	limb
T6779	35883-35892	UBERON:0000309	denotes	body wall
T6780	35971-35975	UBERON:0002101	denotes	limb
T6781	36076-36080	UBERON:0002101	denotes	limb
T6782	36082-36092	PR:000007070	denotes	Engrailed1
T6783	36094-36097	PR:000007070	denotes	En1
T6784	36100-36105	PR:000017448	denotes	Wnt7a
T6785	36111-36116	PR:000009871	denotes	Lmx1b
T6786	36167-36177	GO:0010467	denotes	expression
T6787	36248-36251	PR:000007070	denotes	En1
T6788	36267-36276	GO:0010467	denotes	expressed
T6789	36295-36300	UBERON:0000180	denotes	flank
T6790	36323-36332	UBERON:0000916	denotes	abdominal
T6791	36364-36375	UBERON:0001049	denotes	neural tube
T6792	36377-36402	UBERON:0003077	denotes	somite-derived mesenchyme
T6793	36412-36429	UBERON:0017648	denotes	ventral body wall
T6794	36463-36473	GO:0097617	denotes	hybridized
T6795	36479-36484	PR:000016145	denotes	Tbx15
T6796	36524-36529	UBERON:0000180	denotes	flank
T6797	36650-36672	UBERON:0003081	denotes	lateral plate mesoderm
T6798	36736-36752	UBERON:0015178	denotes	somitic frontier
T7470	36788-36793	SO:0000704	denotes	genes
T7471	36842-36855	UBERON:0002073	denotes	hair follicle
T7472	36842-36867	GO:0001942	denotes	hair follicle development
T7473	36873-36878	PR:000016145	denotes	Tbx15
T7474	36891-36895	SO:0000704	denotes	gene
T7475	36946-36950	UBERON:0001037	denotes	hair
T7476	37034-37038	UBERON:0001037	denotes	hair
T7477	37046-37051	UBERON:0002100	denotes	trunk
T7478	37053-37058	UBERON:0002101	denotes	limbs
T7479	37109-37113	NCBITaxon:10088	denotes	mice
T7480	37126-37131	UBERON:0002100	denotes	trunk
T7481	37173-37183	GO:0010467	denotes	expression
T7482	37190-37196	PR:000004372	denotes	Agouti
T7483	37202-37209	SO:0001060	denotes	isoform
T7484	37263-37269	SO:0001023	denotes	allele
T7485	37325-37330	PR:000016145	denotes	Tbx15
T7486	37421-37426	PR:000016145	denotes	Tbx15
T7487	37473-37477	SO:0000704	denotes	gene
T7488	37546-37551	SO:0000704	denotes	genes
T7489	37579-37599	SO:0001415	denotes	deletion breakpoints
T7490	37609-37619	GO:0010467	denotes	expression
T7491	37631-37636	PR:000016145	denotes	Tbx15
T7492	37721-37727	SO:0001023	denotes	allele
T7493	37740-37746	SO:0001023	denotes	allele
T7494	37759-37764	PR:000016145	denotes	Tbx15
T7495	37774-37780	SO:0001023	denotes	allele
T7496	37847-37857	GO:0010467	denotes	expression
T7497	37861-37866	PR:000016145	denotes	Tbx15
T7498	37949-37955	UBERON:0002067	denotes	dermis
T7499	37971-37981	CHEBI:26130	denotes	pigmentary
T7500	37986-37990	UBERON:0001037	denotes	hair
T7501	38030-38035	PR:000016145	denotes	Tbx15
T7502	38036-38046	GO:0010467	denotes	expression
T7503	38065-38070	UBERON:0000180	denotes	flank
T7504	38133-38137	UBERON:0002101	denotes	limb
T7505	38133-38149	GO:0060173	denotes	limb development
T7506	38165-38187	UBERON:0003081	denotes	lateral plate mesoderm
T7507	38237-38241	SO:0000704	denotes	gene
T7508	38252-38261	UBERON:0000922	denotes	embryonic
T7509	38252-38273	GO:0009790	denotes	embryonic development
T7510	38391-38400	NCBITaxon:40674	denotes	mammalian
T7875	38482-38488	GO:0007601	denotes	visual
T7876	38539-38543	NCBITaxon:10088	denotes	mice
T7877	38663-38667	SO:0000704	denotes	gene
T7878	38663-38678	GO:0010467	denotes	gene expression
T7879	38741-38747	PR:000004372	denotes	Agouti
T7880	38761-38770	UBERON:0000922	denotes	embryonic
T7881	38779-38784	GO:0007567	denotes	natal
T7882	38932-38936	UBERON:0001037	denotes	hair
T7883	38975-38986	CL:0000148	denotes	melanocytes
T7884	39151-39155	NCBITaxon:10088	denotes	mice
T7885	39222-39229	CHEBI:26130	denotes	pigment
T7886	39249-39256	CHEBI:26130	denotes	pigment
T7887	39311-39316	UBERON:0000180	denotes	flank
T7888	39355-39361	PR:000004372	denotes	Agouti
T7889	39401-39408	UBERON:0013235	denotes	ventrum
T7890	39414-39418	UBERON:0001037	denotes	hair
T7891	39419-39426	CHEBI:26130	denotes	pigment
T7892	39492-39499	UBERON:0013235	denotes	ventrum
T7893	39527-39534	SO:0000704	denotes	genetic
T7894	39597-39602	UBERON:0000180	denotes	flank
T7895	40875-40880	PR:000016145	denotes	Tbx15
T7896	40917-40921	UBERON:0001037	denotes	hair
T7897	40930-40937	CHEBI:26130	denotes	pigment
T7898	40951-40961	GO:0010467	denotes	expression
T7899	40986-40992	PR:000004372	denotes	Agouti
T7900	40993-41000	SO:0001060	denotes	isoform
T7901	41111-41116	UBERON:0007023	denotes	adult
T7902	41125-41129	NCBITaxon:10088	denotes	mice
T7903	41199-41203	NCBITaxon:10088	denotes	mice
T7904	41251-41257	UBERON:0007023	denotes	adults
T7905	41324-41328	UBERON:0001037	denotes	hair
T8302	41355-41360	PR:000016145	denotes	Tbx15
T8303	41401-41407	SO:0000417	denotes	domain
T8304	41432-41437	NCBITaxon:10088	denotes	mouse
T8305	41438-41447	PR:000016001	denotes	Brachyury
T8306	41448-41452	SO:0000704	denotes	gene
T8307	41488-41492	UBERON:0002415	denotes	tail
T8308	41512-41517	SO:0000704	denotes	genes
T8309	41589-41596	UBERON:0000479	denotes	tissues
T8310	41601-41624	UBERON:0000468	denotes	multicellular organisms
T8311	41615-41624	NCBITaxon:1	denotes	organisms
T8312	41661-41666	PR:000016145	denotes	Tbx15
T8313	41698-41703	PR:000016146	denotes	Tbx18
T8314	41708-41713	PR:000016150	denotes	Tbx22
T8315	41753-41761	NCBITaxon:7711	denotes	chordate
T8316	41796-41800	SO:0000704	denotes	gene
T8317	41804-41813	NCBITaxon:7740	denotes	amphioxus
T8318	41829-41836	SO:0000853	denotes	homolog
T8319	41844-41847	NCBITaxon:7147	denotes	fly
T8320	41848-41854	SO:0001026	denotes	genome
T8321	41924-41929	SO:0000704	denotes	genes
T8322	41934-41943	GO:0010467	denotes	expressed
T8323	42000-42007	UBERON:0002329	denotes	somites
T8324	42009-42014	PR:000016146	denotes	Tbx18
T8325	42019-42024	PR:000016150	denotes	Tbx22
T8326	42027-42042	UBERON:0009749	denotes	limb mesenchyme
T8327	42044-42049	PR:000016145	denotes	Tbx15
T8328	42054-42059	PR:000016146	denotes	Tbx18
T8329	42079-42089	UBERON:0003104	denotes	mesenchyme
T8330	42101-42106	SO:0000704	denotes	genes
T8331	42108-42113	PR:000016145	denotes	Tbx15
T8332	42132-42137	PR:000016146	denotes	Tbx18
T8333	42141-42146	PR:000016150	denotes	Tbx22
T8334	42294-42298	SO:0000704	denotes	gene
T8335	42303-42308	PR:000016145	denotes	Tbx15
T8336	42310-42315	PR:000016146	denotes	Tbx18
T8337	42321-42326	PR:000016150	denotes	Tbx22
T8338	42383-42399	NCBITaxon:7735	denotes	cephalochordates
T8339	42432-42442	GO:0010467	denotes	expression
T8340	42487-42491	UBERON:0002101	denotes	limb
T8341	42500-42505	UBERON:0002100	denotes	trunk
T8342	42519-42529	NCBITaxon:7742	denotes	vertebrate
T8343	42541-42551	GO:0010467	denotes	Expression
T8344	42555-42560	PR:000016146	denotes	Tbx18
T8345	42565-42570	PR:000016150	denotes	Tbx22
T8346	42596-42605	UBERON:0000922	denotes	embryonic
T8347	42606-42611	UBERON:0000180	denotes	flank
T8348	42612-42622	UBERON:0003104	denotes	mesenchyme
T8349	42644-42649	PR:000016145	denotes	Tbx15
T8350	42734-42739	UBERON:0002100	denotes	trunk
T8351	42825-42832	NCBITaxon:33208	denotes	animals
T8352	42923-42928	UBERON:0002101	denotes	limbs
T8353	42937-42941	UBERON:0000033	denotes	head
T8354	42969-42974	PR:000016150	denotes	Tbx22
T8355	42985-42990	NCBITaxon:9606	denotes	human
T8356	43000-43001	GO:0000805	denotes	X
T8357	43088-43093	PR:000016150	denotes	Tbx22
T8358	43094-43104	GO:0010467	denotes	expression
T8359	43108-43118	_FRAGMENT	denotes	periocular
T8360	43129-43139	UBERON:0004017	denotes	mesenchyme
T8361	43119-43128	UBERON:0000922	denotes	embryonic
T8362	43235-43238	UBERON:0000970	denotes	eye
T8363	43289-43294	PR:000016145	denotes	Tbx15
T8364	43348-43358	GO:0010467	denotes	expression
T8365	43379-43384	NCBITaxon:10088	denotes	mouse
T8366	43385-43390	PR:000016145	denotes	Tbx15
T8367	43424-43429	NCBITaxon:9606	denotes	human
T8368	43430-43435	PR:000016145	denotes	Tbx15
T8369	43499-43505	UBERON:0001456	denotes	facial
T8370	43648-43657	GO:0030849	denotes	autosomal
T8371	43693-43699	UBERON:0001456	denotes	facial
T8372	43735-43739	UBERON:0000165	denotes	oral
T8373	43740-43746	UBERON:0000344	denotes	mucosa
T8374	43766-43771	UBERON:0002398	denotes	hands
T8375	44115-44120	NCBITaxon:9606	denotes	human
T8376	44121-44126	PR:000016145	denotes	TBX15
T8377	44175-44184	GO:0030849	denotes	autosomal
T8378	44259-44266	UBERON:0004089	denotes	midface
T8379	44404-44412	UBERON:0004288	denotes	skeletal
T8380	44404-44424	GO:0001501	denotes	skeletal development
T8381	44486-44490	SO:0000704	denotes	gene
T8382	44491-44495	PR:000003979	denotes	Alx3
T8383	44505-44512	SO:0001023	denotes	allelic
T8384	44525-44528	UBERON:0001690	denotes	ear
T8385	44587-44595	UBERON:0004288	denotes	skeletal
T8386	44618-44622	PR:000003979	denotes	Alx3
T8387	44626-44630	PR:000003980	denotes	Alx4
T8388	44703-44707	PR:000003979	denotes	Alx3
T8389	44747-44752	PR:000016145	denotes	Tbx15
T8390	44753-44761	UBERON:0004288	denotes	skeletal
T9202	44829-44834	PR:000016145	denotes	Tbx15
T9203	44835-44845	GO:0010467	denotes	Expression
T9204	44898-44903	PR:000016145	denotes	Tbx15
T9205	44907-44914	CHEBI:26130	denotes	pigment
T9206	44958-44964	PR:000004372	denotes	Agouti
T9207	44972-44977	GO:0007567	denotes	natal
T9208	44978-44985	NCBITaxon:33208	denotes	animals
T9209	44996-45002	PR:000004372	denotes	Agouti
T9210	45011-45020	GO:0010467	denotes	expressed
T9211	45028-45034	UBERON:0000922	denotes	embryo
T9212	45085-45091	UBERON:0002067	denotes	dermis
T9213	45132-45141	UBERON:0000922	denotes	embryonic
T9214	45142-45148	PR:000004372	denotes	Agouti
T9215	45149-45159	GO:0010467	denotes	expression
T9216	45171-45178	NCBITaxon:33208	denotes	animals
T9217	45218-45223	PR:000016145	denotes	Tbx15
T9218	45300-45305	SO:0000704	denotes	genes
T9219	45553-45579	_FRAGMENT	denotes	proliferative expansion of
T9220	45582-45597	GO:0008283	denotes	cell population
T9221	45753-45757	NCBITaxon:10088	denotes	mice
T9222	45801-45807	PR:000004372	denotes	Agouti
T9223	45808-45818	GO:0010467	denotes	expression
T9224	45826-45831	GO:0007567	denotes	natal
T9225	45840-45847	NCBITaxon:33208	denotes	animals
T9226	45941-45950	UBERON:0000922	denotes	embryonic
T9227	45941-45956	CL:0002321	denotes	embryonic cells
T9228	45973-45983	UBERON:0003104	denotes	mesenchyme
T9229	46058-46069	GO:0008283	denotes	proliferate
T9230	46284-46288	UBERON:0001037	denotes	hair
T9231	46306-46310	NCBITaxon:10088	denotes	mice
T9232	46427-46432	UBERON:0000180	denotes	flank
T9233	46459-46468	UBERON:0000922	denotes	embryonic
T9234	46469-46479	UBERON:0003104	denotes	mesenchyme
T9235	46481-46491	GO:0010467	denotes	expression
T9236	46495-46500	PR:000016145	denotes	Tbx15
T9237	46505-46511	PR:000004372	denotes	Agouti
T9238	46555-46560	PR:000016145	denotes	Tbx15
T9239	46586-46592	PR:000004372	denotes	Agouti
T9240	46623-46633	UBERON:0003104	denotes	mesenchyme
T9241	46659-46664	PR:000016145	denotes	Tbx15
T9242	46677-46687	GO:0010467	denotes	expression
T9243	46712-46718	PR:000004372	denotes	Agouti
T9244	46719-46726	SO:0001060	denotes	isoform
T9245	46734-46739	GO:0007567	denotes	natal
T9246	46740-46744	NCBITaxon:10088	denotes	mice
T9247	46781-46786	GO:0007567	denotes	natal
T9248	46787-46797	GO:0010467	denotes	expression
T9249	46801-46806	PR:000016145	denotes	Tbx15
T9250	46888-46894	PR:000004372	denotes	Agouti
T9251	46927-46932	PR:000016145	denotes	Tbx15
T9252	46960-46965	SO:0000704	denotes	genes
T9253	46981-46987	PR:000004372	denotes	Agouti
T9254	46995-46999	UBERON:0001037	denotes	hair
T9255	46995-46999	_FRAGMENT	denotes	hair
T9256	47011-47021	CL:0002483	denotes	melanocyte
T9257	47088-47095	NCBITaxon:33208	denotes	animals
T9258	47114-47120	PR:000004372	denotes	Agouti
T9259	47121-47127	SO:0001023	denotes	allele
T9260	47153-47157	PR:000003980	denotes	Alx4
T9261	47171-47177	PR:000004372	denotes	Agouti
T9262	47182-47191	GO:0010467	denotes	expressed
T9263	47203-47212	UBERON:0000922	denotes	embryonic
T9264	47213-47223	UBERON:0003104	denotes	mesenchyme
T9265	47252-47265	UBERON:0002073	denotes	hair-follicle
T9266	47277-47281	UBERON:0002101	denotes	limb
T9267	47277-47281	_FRAGMENT	denotes	limb
T9268	47299-47310	GO:0060173	denotes	development
T9269	47405-47415	GO:0010467	denotes	expression
T9270	47443-47447	PR:000003980	denotes	Alx4
T9271	47460-47464	PR:000003979	denotes	Alx3
T9272	47469-47473	PR:000010687	denotes	Msx2
T9273	47520-47527	UBERON:0000922	denotes	embryos
T10004	49220-49230	GO:0010467	denotes	expression
T9952	47592-47596	UBERON:0002101	denotes	Limb
T9953	47616-47621	PR:000016145	denotes	Tbx15
T9954	47660-47664	UBERON:0001037	denotes	hair
T9955	47678-47683	UBERON:0002101	denotes	limbs
T9956	47730-47734	UBERON:0001037	denotes	hair
T9957	47757-47761	UBERON:0001037	denotes	hair
T9958	47807-47814	CHEBI:26130	denotes	pigment
T9959	47837-47841	UBERON:0002101	denotes	limb
T9960	47874-47878	NCBITaxon:10088	denotes	mice
T9961	47965-47968	PR:000007070	denotes	En1
T9962	47972-47977	PR:000017448	denotes	Wnt7a
T9963	48030-48034	UBERON:0002101	denotes	limb
T9964	48040-48046	UBERON:0001137	denotes	dorsum
T9965	48050-48057	UBERON:0013235	denotes	ventrum
T9966	48082-48089	UBERON:0013235	denotes	ventrum
T9967	48093-48099	UBERON:0001137	denotes	dorsum
T9968	48178-48184	PR:000004372	denotes	Agouti
T9969	48185-48195	GO:0010467	denotes	expression
T9970	48215-48219	UBERON:0001037	denotes	hair
T9971	48300-48308	UBERON:0013623	denotes	footpads
T9972	48326-48329	PR:000007070	denotes	En1
T9973	48337-48341	NCBITaxon:10088	denotes	mice
T9974	48358-48365	CHEBI:26130	denotes	pigment
T9975	48427-48430	PR:000007070	denotes	En1
T9976	48447-48452	PR:000017448	denotes	Wnt7a
T9977	48465-48474	_FRAGMENT	denotes	migration
T9978	48502-48504	_FRAGMENT	denotes	of
T9979	48513-48518	GO:0016477	denotes	cells
T9980	48478-48491	_FRAGMENT	denotes	proliferation
T9981	48513-48518	GO:0008283	denotes	cells
T9982	48505-48512	CHEBI:26130	denotes	pigment
T9983	48505-48518	CL:0000147	denotes	pigment cells
T9984	48530-48539	UBERON:0007376	denotes	epidermis
T9985	48620-48627	GO:0065007	denotes	control
T9986	48644-48649	UBERON:0002100	denotes	trunk
T9987	48661-48666	PR:000016145	denotes	Tbx15
T9988	48696-48703	GO:0065007	denotes	control
T9989	48720-48724	UBERON:0002101	denotes	limb
T9990	48739-48744	PR:000009871	denotes	Lmx1b
T9991	48752-48758	SO:0000417	denotes	domain
T9992	48804-48809	PR:000017448	denotes	Wnt7a
T9993	48814-48817	PR:000007070	denotes	En1
T9994	48945-48950	PR:000016145	denotes	Tbx15
T9995	48955-48960	PR:000009871	denotes	Lmx1b
T9996	48981-48992	UBERON:0003104	denotes	mesenchymal
T9997	48981-48998	CL:0000134	denotes	mesenchymal cells
T9998	49038-49048	GO:0010467	denotes	expression
T9999	49116-49121	UBERON:0000180	denotes	flank
T10000	49123-49128	PR:000016145	denotes	Tbx15
T10001	49137-49141	UBERON:0002101	denotes	limb
T10002	49143-49148	PR:000009871	denotes	Lmx1b
T10003	49209-49214	PR:000009871	denotes	Lmx1b
T10005	49245-49249	UBERON:0002101	denotes	limb
T10006	49261-49266	PR:000017448	denotes	Wnt7a
T10007	49300-49308	UBERON:0000924	denotes	ectoderm
T10008	49370-49375	PR:000017448	denotes	Wnt7a
T10009	49410-49418	UBERON:0000924	denotes	ectoderm
T10010	49422-49425	PR:000007070	denotes	En1
T10011	49441-49449	UBERON:0000924	denotes	ectoderm
T10012	49516-49526	GO:0010467	denotes	expression
T10013	49600-49623	UBERON:0004356	denotes	apical ectodermal ridge
T10014	49708-49711	PR:000007070	denotes	En1
T10015	49715-49720	PR:000017448	denotes	Wnt7a
T10016	49776-49780	UBERON:0001037	denotes	hair
T10017	49914-49924	UBERON:0000924	denotes	ectodermal
T10018	49946-49953	GO:0065007	denotes	control
T10019	49977-49987	UBERON:0003104	denotes	mesenchyme
T10020	50002-50007	UBERON:0002101	denotes	limbs
T10021	50025-50030	UBERON:0002100	denotes	trunk
T10022	50046-50050	UBERON:0002101	denotes	limb
T10023	50056-50070	UBERON:0001911	denotes	mammary glands
T10024	50137-50147	UBERON:0000483	denotes	epithelial
T10025	50148-50159	UBERON:0003104	denotes	mesenchymal
T10026	50223-50237	UBERON:0001911	denotes	mammary glands
T10027	50260-50267	NCBITaxon:33208	denotes	animals
T10028	50324-50331	GO:0065007	denotes	control
T10029	50363-50368	UBERON:0002100	denotes	trunk
T10030	50387-50392	UBERON:0002101	denotes	limbs
T10031	50497-50509	UBERON:0011270	denotes	dorsal trunk
T10032	50510-50518	UBERON:0000924	denotes	ectoderm
T10033	50551-50561	GO:0010467	denotes	expression
T10034	50565-50570	PR:000016145	denotes	Tbx15
T10035	50574-50586	UBERON:0011270	denotes	dorsal trunk
T10036	50587-50597	UBERON:0003104	denotes	mesenchyme
T10037	50696-50702	PR:000004372	denotes	Agouti
T10038	50703-50713	GO:0010467	denotes	expression
T10039	50715-50722	CHEBI:26130	denotes	pigment
T10040	50715-50727	CL:0000147	denotes	pigment-cell
T10041	50715-50739	GO:0070285	denotes	pigment-cell development
T10042	50745-50749	UBERON:0001037	denotes	hair
T10043	50787-50792	PR:000016145	denotes	Tbx15
T10044	50793-50803	GO:0010467	denotes	expression
T10045	50839-50842	PR:000007070	denotes	En1
T10046	50843-50853	GO:0010467	denotes	expression
T10047	50955-50963	UBERON:0004347	denotes	limb-bud
T10048	51038-51043	UBERON:0002100	denotes	trunk
T10049	51044-51052	UBERON:0000924	denotes	ectoderm
T10050	51076-51080	UBERON:0002101	denotes	limb
T10051	51221-51229	UBERON:0000924	denotes	ectoderm
T10052	51242-51246	UBERON:0002101	denotes	limb
T10053	51325-51329	UBERON:0002101	denotes	limb
T10054	51379-51383	UBERON:0002101	denotes	limb
T10055	51384-51392	UBERON:0000926	denotes	mesoderm
T10056	51510-51515	UBERON:0002101	denotes	limbs
T10057	51524-51547	UBERON:0004356	denotes	apical ectodermal ridge
T10058	51564-51574	GO:0010467	denotes	expression
T10059	51578-51583	PR:000016145	denotes	Tbx15
T10060	51591-51596	UBERON:0002100	denotes	trunk
T10061	51612-51617	UBERON:0002101	denotes	limbs
T10062	51638-51642	UBERON:0002101	denotes	limb
T10063	51737-51746	UBERON:0004347	denotes	limb buds
T10064	51906-51916	GO:0010467	denotes	expression
T10065	51920-51925	PR:000016145	denotes	Tbx15
T10066	51929-51947	UBERON:2000164	denotes	ventral mesenchyme
T10067	52067-52072	PR:000016145	denotes	Tbx15
T10068	52073-52083	GO:0010467	denotes	expression
T10069	52128-52136	UBERON:0000926	denotes	mesoderm
T10070	52183-52188	PR:000016145	denotes	Tbx15
T10071	52271-52303	GO:0048263	denotes	establishment of dorsal identity
T10072	52307-52312	PR:000016145	denotes	Tbx15
T10073	52388-52398	UBERON:0003104	denotes	mesenchyme
T10074	52417-52425	UBERON:0000924	denotes	ectoderm
T11185	52454-52459	PR:000016145	denotes	Tbx15
T11186	52469-52476	NCBITaxon:40674	denotes	Mammals
T11187	52489-52505	UBERON:0015178	denotes	somitic frontier
T11188	52547-52553	UBERON:0002329	denotes	somite
T11189	52569-52582	UBERON:0003081	denotes	lateral plate
T11190	52591-52599	UBERON:0000926	denotes	mesoderm
T11191	52772-52777	GO:0007567	denotes	natal
T11192	52778-52785	NCBITaxon:33208	denotes	animals
T11193	52933-52949	UBERON:0015178	denotes	somitic frontier
T11194	53156-53160	PR:000010686	denotes	Msx1
T11195	53168-53178	GO:0010467	denotes	expression
T11196	53199-53205	UBERON:0002329	denotes	somite
T11197	53214-53225	UBERON:0003104	denotes	mesenchymal
T11198	53214-53231	CL:0000134	denotes	mesenchymal cells
T11199	53251-53257	UBERON:0002067	denotes	dermis
T11200	53270-53276	UBERON:2001463	denotes	stripe
T11201	53392-53397	GO:0007567	denotes	natal
T11202	53398-53407	NCBITaxon:40674	denotes	mammalian
T11203	53479-53486	CHEBI:26130	denotes	pigment
T11204	53551-53561	GO:0010467	denotes	expression
T11205	53565-53569	PR:000010686	denotes	Msx1
T11206	53574-53581	NCBITaxon:9989	denotes	rodents
T11207	53646-53653	NCBITaxon:40674	denotes	mammals
T11208	53688-53692	UBERON:0001037	denotes	hair
T11209	53759-53767	NCBITaxon:9654	denotes	Raccoons
T11210	53769-53778	NCBITaxon:55153	denotes	squirrels
T11211	53780-53786	NCBITaxon:119825	denotes	skunks
T11212	53833-53840	UBERON:2001463	denotes	stripes
T11213	53931-53947	UBERON:0015178	denotes	somitic frontier
T11214	53964-53968	PR:000010686	denotes	Msx1
T11215	54037-54042	PR:000016145	denotes	Tbx15
T11216	54073-54077	NCBITaxon:10088	denotes	mice
T11217	54096-54100	UBERON:0010166	denotes	coat
T11218	54166-54173	NCBITaxon:40674	denotes	mammals
T11219	54182-54190	UBERON:2002284	denotes	markings
T11220	54210-54213	NCBITaxon:9615	denotes	dog
T11221	54278-54299	NCBITaxon:42413	denotes	Peromyscus polionotus
T11222	54389-54399	NCBITaxon:subspecies	denotes	subspecies
T11223	54508-54517	NCBITaxon:10040	denotes	deer mice
T11224	54620-54627	NCBITaxon:33208	denotes	animals
T11225	54663-54673	GO:0065007	denotes	regulation
T11226	54687-54692	PR:000016145	denotes	Tbx15
T11227	54749-54754	PR:000016145	denotes	Tbx15
T11228	54758-54762	UBERON:0010166	denotes	coat
T11229	54798-54805	SO:0000704	denotes	genetic
T11230	54851-54858	NCBITaxon:40674	denotes	mammals
T11231	54931-54941	GO:0010467	denotes	expression
T11232	54945-54950	PR:000016145	denotes	Tbx15
T11233	54960-54971	NCBITaxon:7742	denotes	vertebrates
T11234	55033-55041	UBERON:0004288	denotes	skeleton
T11235	55057-55067	CHEBI:26130	denotes	pigmentary
T11772	55109-55113	NCBITaxon:10088	denotes	mice
T11773	55300-55305	PR:000008703	denotes	Hoxb6
T11774	55321-55325	NCBITaxon:10088	denotes	mice
T11775	55429-55433	NCBITaxon:10088	denotes	mice
T11776	55452-55456	PR:000033987	denotes	lacZ
T11777	55466-55472	SO:0001023	denotes	allele
T11778	55606-55610	NCBITaxon:10088	denotes	mice
T11779	55898-55904	SO:0001023	denotes	allele
T11780	56049-56056	GO:0007618	denotes	matings
T11781	56077-56081	UBERON:0010148	denotes	plug
T11782	56107-56114	GO:0007567	denotes	natally
T11783	56127-56132	GO:0007567	denotes	birth
T12033	56201-56205	UBERON:0001037	denotes	hair
T12034	56240-56244	UBERON:0002101	denotes	limb
T12035	56245-56259	UBERON:0000014	denotes	region of skin
T12036	56353-56371	CHEBI:32139	denotes	sodium bicarbonate
T12037	56452-56456	UBERON:0001037	denotes	hair
T12038	56663-56667	UBERON:0010511	denotes	awls
T12039	56672-56680	UBERON:0010510	denotes	auchenes
T12040	56726-56734	GO:0007601	denotes	visually
T12041	56757-56763	_FRAGMENT	denotes	zigzag
T12042	56769-56774	UBERON:0010513	denotes	hairs
T12043	56812-56816	UBERON:0001037	denotes	hair
T12044	56852-56857	UBERON:0001037	denotes	hairs
T12045	56883-56889	UBERON:0001137	denotes	dorsum
T12046	56896-56903	UBERON:0013235	denotes	ventrum
T12047	56931-56938	NCBITaxon:33208	denotes	animals
T12048	57042-57046	UBERON:0010511	denotes	awls
T12049	57051-57059	UBERON:0010510	denotes	auchenes
T12050	57144-57155	CHEBI:51686	denotes	hematoxylin
T12051	57171-57175	CHEBI:49168	denotes	DOPA
T12052	57190-57196	UBERON:0002067	denotes	dermis
T12053	57201-57210	UBERON:0007376	denotes	epidermis
T12054	57253-57267	CHEBI:63004	denotes	sodium bromide
T12055	57306-57320	UBERON:0002073	denotes	hair follicles
T12056	57340-57346	UBERON:0002067	denotes	dermis
T12057	57411-57417	CHEBI:15765	denotes	L-DOPA
T12058	57469-57485	CHEBI:37586	denotes	sodium phosphate
T12059	57553-57561	CHEBI:75958	denotes	solution
T12060	57688-57699	CL:0000148	denotes	melanocytes
T12061	57740-57748	CHEBI:50913	denotes	fixative
T12434	57914-57918	NCBITaxon:10088	denotes	mice
T12435	57999-58006	NCBITaxon:33208	denotes	animals
T12436	58159-58166	NCBITaxon:33208	denotes	animals
T12437	58176-58183	SO:0000704	denotes	genetic
T12438	58322-58334	SO:0001249	denotes	physical map
T12439	58340-58343	SO:0000153	denotes	BAC
T12440	58344-58358	SO:0000040	denotes	genomic clones
T12441	58419-58425	SO:0001026	denotes	Genome
T12442	58496-58500	SO:0000153	denotes	BACs
T12443	58625-58631	SO:0000112	denotes	Primer
T12444	58933-58936	SO:0000331	denotes	STS
T12445	58954-58961	SO:0001026	denotes	Genomic
T12446	59015-59021	SO:0001026	denotes	Genome
T12447	59073-59079	SO:0001026	denotes	genome
T12448	59144-59149	SO:0000704	denotes	genes
T12449	59156-59170	CHEBI:35350	denotes	hydroxysteroid
T12450	59197-59203	PR:000008867	denotes	Hsd3b3
T12451	59205-59211	PR:000008786	denotes	Hsd3b2
T12452	59213-59219	PR:000008870	denotes	Hsd3b6
T12453	59225-59231	PR:000008785	denotes	Hsd3b1
T12454	59236-59245	CHEBI:24669	denotes	hydroacid
T12455	59255-59259	PR:000008442	denotes	Hao3
T12456	59293-59298	PR:000017370	denotes	Wars2
T12457	59308-59312	SO:0000704	denotes	gene
T12458	59314-59319	PR:000016145	denotes	Tbx15
T12459	59333-59337	SO:0000704	denotes	gene
T12460	59339-59352	PR:000015456	denotes	4931427F14Rik
T12461	59361-59367	SO:0001026	denotes	genome
T12462	59381-59388	SO:0000112	denotes	primers
T12463	59470-59484	SO:0000132	denotes	reverse primer
T12464	59538-59545	SO:0000112	denotes	primers
T12465	59666-59673	SO:0000112	denotes	primers
T12466	59695-59703	SO:0000999	denotes	BAC ends
T12467	59719-59725	SO:0001026	denotes	genome
T12468	59796-59799	SO:0000153	denotes	BAC
T12469	59887-59894	SO:0000112	denotes	primers
T12470	59995-59997	SO:0000028	denotes	bp
T12471	60040-60042	SO:0000028	denotes	bp
T12940	60211-60215	SO:0000243	denotes	IRES
T12941	60216-60220	PR:000033987	denotes	LacZ
T12942	60225-60233	SO:0005853	denotes	cassette
T12943	60311-60316	PR:P23940	denotes	BamHI
T12944	60366-60397	SO:0000315	denotes	transcriptional initiation site
T12945	60433-60437	SO:0000147	denotes	exon
T12946	60450-60452	CL:0002322	denotes	ES
T12947	60482-60493	UBERON:0000358	denotes	blastocysts
T12948	60538-60542	NCBITaxon:10088	denotes	mice
T12949	60555-60562	NCBITaxon:33208	denotes	animals
T13085	60573-60586	GO:0097617	denotes	hybridization
T13086	60595-60608	GO:0097617	denotes	hybridization
T13087	60658-60669	CHEBI:42098	denotes	digoxigenin
T13088	60807-60814	UBERON:0000922	denotes	Embryos
T13089	60823-60828	GO:0007567	denotes	natal
T13090	60883-60887	NCBITaxon:10088	denotes	mice
T13091	60889-60896	UBERON:0000922	denotes	Embryos
T13092	60966-60971	GO:0007567	denotes	natal
T13093	61024-61029	PR:000016145	denotes	Tbx15
T13094	61066-61073	SO:0000112	denotes	primers
T13095	61135-61140	SO:0000147	denotes	exons
T13096	61159-61162	PR:000007070	denotes	En1
T13097	61195-61202	SO:0001026	denotes	genomic
T13098	61213-61220	SO:0000112	denotes	primers
T13099	61288-61292	SO:0000147	denotes	exon
T13100	61299-61305	PR:000004372	denotes	Agouti
T13101	61331-61345	SO:0000010	denotes	protein-coding
T13282	61357-61366	UBERON:0000922	denotes	Embryonic
T13283	61412-61419	UBERON:0000922	denotes	embryos
T13284	61464-61472	CHEBI:75958	denotes	solution
T13285	61478-61487	UBERON:0000922	denotes	embryonic
T13286	61518-61523	UBERON:0000180	denotes	flank
T13287	61624-61630	UBERON:0000473	denotes	testes
T13288	61643-61650	NCBITaxon:33208	denotes	animals
T13289	61738-61747	UBERON:0000309	denotes	body wall
T13290	61762-61767	UBERON:0006983	denotes	point
T13291	61794-61799	UBERON:0002101	denotes	limbs
T13292	61805-61813	UBERON:0003916	denotes	fat pads
T13293	61880-61886	UBERON:0000473	denotes	testes
T13294	61939-61953	UBERON:0006643	denotes	testis capsule
T13295	61989-61998	UBERON:0000922	denotes	embryonic
T13296	62022-62028	UBERON:0000473	denotes	testes
T13297	62057-62073	UBERON:0003684	denotes	abdominal cavity
T13298	62112-62121	UBERON:0000309	denotes	body wall
T13299	62151-62155	NCBITaxon:10088	denotes	mice
T13300	62211-62215	UBERON:0001037	denotes	hair
T13301	62239-62245	UBERON:0000473	denotes	testes
T13532	62286-62302	UBERON:0015178	denotes	somitic frontier
T13533	62307-62312	PR:000008703	denotes	Hoxb6
T13534	62317-62326	SO:0000902	denotes	transgene
T13535	62383-62392	GO:0010467	denotes	expressed
T13536	62400-62413	_FRAGMENT	denotes	lateral plate
T13537	62434-62442	UBERON:0003081	denotes	mesoderm
T13538	62426-62442	UBERON:0003077	denotes	somitic mesoderm
T13539	62450-62455	UBERON:0002100	denotes	trunk
T13540	62476-62483	NCBITaxon:33208	denotes	Animals
T13541	62513-62522	SO:0000902	denotes	transgene
T13542	62545-62549	SO:0000704	denotes	gene
T13543	62698-62713	UBERON:0009571	denotes	ventral midline
T13544	62936-62943	NCBITaxon:33208	denotes	animals
T13545	62960-62966	SO:0001023	denotes	allele
T13546	63065-63071	UBERON:0002329	denotes	somite
T13547	63072-63085	UBERON:0003081	denotes	lateral plate
T769	8328-8338	CL:0000148	denotes	melanocyte
T12937	60083-60087	SO:0000704	denotes	Gene
T12938	60109-60115	SO:0001023	denotes	allele
T12939	60119-60124	PR:000016145	denotes	Tbx15
T770	8371-8378	CHEBI:26130	denotes	pigment
T5280	24295-24305	GO:0010467	denotes	Expression
T771	8399-8403	UBERON:0001037	denotes	hair
T765	8091-8097	PR:000004372	denotes	Agouti
T766	8098-8108	GO:0010467	denotes	expression
T767	8153-8159	UBERON:0002329	denotes	somite
T768	8165-8178	UBERON:0003081	denotes	lateral plate
T772	8458-8464	UBERON:0002329	denotes	somite
T773	8465-8478	UBERON:0003081	denotes	lateral plate
T774	8529-8534	NCBITaxon:10088	denotes	mouse
T775	8552-8555	UBERON:0001690	denotes	ear
T776	8622-8627	UBERON:0000180	denotes	flank
T777	8628-8632	UBERON:0010166	denotes	coat
T778	8685-8691	PR:000004372	denotes	Agouti
T779	8692-8702	SO:0000673	denotes	transcript
T780	8730-8734	SO:0000704	denotes	gene
T781	8761-8767	SO:0001023	denotes	allele
T782	8778-8781	UBERON:0001690	denotes	ear
T783	8814-8819	PR:000016145	denotes	Tbx15
T784	8864-8873	GO:0010467	denotes	expressed
T785	8946-8968	UBERON:0002204	denotes	musculoskeletal system
T786	8970-8979	UBERON:0000922	denotes	Embryonic
T787	8980-8990	GO:0010467	denotes	expression
T788	9032-9037	PR:000016145	denotes	Tbx15
T789	9111-9122	UBERON:0003104	denotes	mesenchymal
T790	9111-9128	CL:0000134	denotes	mesenchymal cells
T791	9147-9152	UBERON:0000180	denotes	flank
T792	9275-9282	NCBITaxon:40674	denotes	mammals
R6399	T9220	T9219	_lexicallyChainedTo	cell population,proliferative expansion of
R8427	T12042	T12041	_lexicallyChainedTo	hairs,zigzag
R9496	T13537	T13536	_lexicallyChainedTo	mesoderm,lateral plate
R2276	T3409	T3408	_lexicallyChainedTo	skin,area of
R3086	T4445	T4444	_lexicallyChainedTo	exons,portions of
R3660	T5293	T5292	_lexicallyChainedTo	head,mesenchymal tissues of
R3661	T5294	T5292	_lexicallyChainedTo	trunk,mesenchymal tissues of
R3662	T5295	T5292	_lexicallyChainedTo	limbs,mesenchymal tissues of
R5785	T8360	T8359	_lexicallyChainedTo	mesenchyme,periocular
R6400	T9256	T9255	_lexicallyChainedTo	melanocyte,hair
R6401	T9268	T9267	_lexicallyChainedTo	development,limb
R6888	T9978	T9977	_lexicallyChainedTo	of,migration
R6889	T9978	T9980	_lexicallyChainedTo	of,proliferation
R6890	T9979	T9978	_lexicallyChainedTo	cells,of
R6891	T9981	T9978	_lexicallyChainedTo	cells,of

2_test

Id	Subject	Object	Predicate	Lexical cue
14737183-1473152-84902972	5180-5184	1473152	denotes	1992
14737183-12509752-84902965	2599-2603	12509752	denotes	2003
14737183-11418857-84902966	3403-3407	11418857	denotes	2001
14737183-11357131-84902967	3424-3428	11357131	denotes	2001
14737183-12859616-84902968	3715-3719	12859616	denotes	2003
14737183-8948501-84902969	4181-4185	8948501	denotes	1996
14737183-11041357-84902970	4200-4204	11041357	denotes	2000
14737183-11584301-84902971	4457-4461	11584301	denotes	2001
14737183-8449404-84902973	5200-5204	8449404	denotes	1993
14737183-7588057-84902974	5281-5285	7588057	denotes	1995
14737183-1473152-84902975	5565-5569	1473152	denotes	1992
14737183-8125260-84902976	5571-5575	8125260	denotes	1994
14737183-8449404-84902977	5591-5595	8449404	denotes	1993
14737183-8202545-84902978	5613-5617	8202545	denotes	1994
14737183-8125260-84902979	6354-6358	8125260	denotes	1994
14737183-8202545-84902980	6376-6380	8202545	denotes	1994
14737183-8125260-84902981	6482-6486	8125260	denotes	1994
14737183-8202545-84902982	6504-6508	8202545	denotes	1994
14737183-7588057-84902983	6871-6875	7588057	denotes	1995
14737183-4642991-84902984	7548-7552	4642991	denotes	1972
14737183-6220621-84902985	7568-7572	6220621	denotes	1983
14737183-11023864-84902986	7598-7602	11023864	denotes	2000
14737183-12559495-84902987	7619-7623	12559495	denotes	2003
14737183-13654621-84902988	8563-8567	13654621	denotes	1959
14737183-5956248-84902989	12980-12984	5956248	denotes	1966
14737183-13654621-84902990	14936-14940	13654621	denotes	1959
14737183-13654621-84902991	15738-15742	13654621	denotes	1959
14737183-24539711-84902992	20549-20553	24539711	denotes	1951
14737183-13654621-84902993	20561-20565	13654621	denotes	1959
14737183-489953-84902994	20583-20587	489953	denotes	1979
14737183-9693034-84902995	21037-21041	9693034	denotes	1998
14737183-9693034-84902996	22115-22119	9693034	denotes	1998
14737183-9503012-84902997	22331-22335	9503012	denotes	1998
14737183-9693034-84902998	22451-22455	9693034	denotes	1998
14737183-12175500-84902999	22473-22477	12175500	denotes	2002
14737183-1376319-84903000	22845-22849	1376319	denotes	1992
14737183-9693034-84903001	24362-24366	9693034	denotes	1998
14737183-781177-84903002	29845-29849	781177	denotes	1976
14737183-11089928-84903003	30786-30790	11089928	denotes	2000
14737183-11023864-84903004	30816-30820	11023864	denotes	2000
14737183-11401392-84903005	30834-30838	11401392	denotes	2001
14737183-12586060-84903006	30858-30862	12586060	denotes	2003
14737183-12559495-84903007	30879-30883	12559495	denotes	2003
14737183-11023864-84903008	33189-33193	11023864	denotes	2000
14737183-11401392-84903009	33207-33211	11401392	denotes	2001
14737183-12586060-84903010	33231-33235	12586060	denotes	2003
14737183-12559495-84903011	33252-33256	12559495	denotes	2003
14737183-10686603-84903012	33864-33868	10686603	denotes	2000
14737183-10686603-84903013	33900-33904	10686603	denotes	2000
14737183-9916792-84903014	34007-34011	9916792	denotes	1999
14737183-12560810-84903015	36241-36245	12560810	denotes	2003
14737183-10431194-84903016	38725-38729	10431194	denotes	1999
14737183-11352264-84903017	41650-41654	11352264	denotes	2001
14737183-11063699-84903018	41872-41876	11063699	denotes	2000
14737183-9693034-84903019	42164-42168	9693034	denotes	1998
14737183-11118889-84903020	42183-42187	11118889	denotes	2001
14737183-12374769-84903021	42206-42210	12374769	denotes	2002
14737183-12412015-84903022	42224-42228	12412015	denotes	2002
14737183-12666195-84903023	42242-42246	12666195	denotes	2003
14737183-11559848-84903024	43058-43062	11559848	denotes	2001
14737183-12374769-84903025	43158-43162	12374769	denotes	2002
14737183-12412015-84903026	43176-43180	12412015	denotes	2002
14737183-12666195-84903027	43194-43198	12666195	denotes	2003
14737183-9693034-84903028	43408-43412	9693034	denotes	1998
14737183-3989825-84903029	43610-43614	3989825	denotes	1985
14737183-1619638-84903030	43921-43925	1619638	denotes	1992
14737183-8950682-84903031	43941-43945	8950682	denotes	1996
14737183-9546838-84903032	43963-43967	9546838	denotes	1998
14737183-10955485-84903033	43984-43988	10955485	denotes	2000
14737183-8205327-84903034	44294-44298	8205327	denotes	1994
14737183-13654621-84903035	44432-44436	13654621	denotes	1959
14737183-9676189-84903036	44547-44551	9676189	denotes	1998
14737183-11148447-84903037	45659-45663	11148447	denotes	2001
14737183-9374397-84903038	47322-47326	9374397	denotes	1997
14737183-9636085-84903039	47328-47332	9636085	denotes	1998
14737183-11017806-84903040	47344-47348	11017806	denotes	2000
14737183-11106354-84903041	47363-47367	11106354	denotes	2000
14737183-11137991-84903042	47389-47393	11137991	denotes	2001
14737183-8684466-84903043	48073-48077	8684466	denotes	1996
14737183-7885472-84903044	48118-48122	7885472	denotes	1995
14737183-9362463-84903045	48554-48558	9362463	denotes	1997
14737183-9463360-84903046	48574-48578	9463360	denotes	1998
14737183-7585966-84903047	48833-48837	7585966	denotes	1995
14737183-7501017-84903048	48852-48856	7501017	denotes	1995
14737183-9362463-84903049	48871-48875	9362463	denotes	1997
14737183-9199358-84903050	48890-48894	9199358	denotes	1997
14737183-9463360-84903051	48910-48914	9463360	denotes	1998
14737183-12455631-84903052	48933-48937	12455631	denotes	2002
14737183-9409672-84903053	49166-49170	9409672	denotes	1997
14737183-9108362-84903054	49187-49191	9108362	denotes	1997
14737183-7585966-84903055	49324-49328	7585966	denotes	1995
14737183-9362463-84903056	49343-49347	9362463	denotes	1997
14737183-9463360-84903057	49363-49367	9463360	denotes	1998
14737183-8684466-84903058	49465-49469	8684466	denotes	1996
14737183-9362463-84903059	49484-49488	9362463	denotes	1997
14737183-9199358-84903060	49503-49507	9199358	denotes	1997
14737183-9409672-84903061	49640-49644	9409672	denotes	1997
14737183-9108362-84903062	49661-49665	9108362	denotes	1997
14737183-10837030-84903063	49681-49685	10837030	denotes	2000
14737183-7885472-84903064	49853-49857	7885472	denotes	1995
14737183-8684466-84903065	49873-49877	8684466	denotes	1996
14737183-9409672-84903066	51263-51267	9409672	denotes	1997
14737183-10837120-84903067	51269-51273	10837120	denotes	2000
14737183-9108362-84903068	51290-51294	9108362	denotes	1997
14737183-10837030-84903069	51310-51314	10837030	denotes	2000
14737183-9409672-84903070	51354-51358	9409672	denotes	1997
14737183-10837120-84903071	51360-51364	10837120	denotes	2000
14737183-9409672-84903072	51409-51413	9409672	denotes	1997
14737183-9108362-84903073	51430-51434	9108362	denotes	1997
14737183-7889567-84903074	51799-51803	7889567	denotes	1995
14737183-8548816-84903075	51821-51825	8548816	denotes	1996
14737183-8674413-84903076	51840-51844	8674413	denotes	1996
14737183-9409672-84903077	51861-51865	9409672	denotes	1997
14737183-10837120-84903078	51867-51871	10837120	denotes	2000
14737183-4642991-84903079	52666-52670	4642991	denotes	1972
14737183-6220621-84903080	52686-52690	6220621	denotes	1983
14737183-11023864-84903081	52716-52720	11023864	denotes	2000
14737183-12559495-84903082	52737-52741	12559495	denotes	2003
14737183-10769239-84903083	53325-53329	10769239	denotes	2000
14737183-10716450-84903084	60191-60195	10716450	denotes	2000
14737183-8231863-84903085	60800-60804	8231863	denotes	1993
14737183-10686603-84903086	62374-62378	10686603	denotes	2000
T29036	2599-2603	12509752	denotes	2003
T98798	3403-3407	11418857	denotes	2001
T65883	3424-3428	11357131	denotes	2001
T79545	3715-3719	12859616	denotes	2003
T95684	4181-4185	8948501	denotes	1996
T20335	4200-4204	11041357	denotes	2000
T48290	4457-4461	11584301	denotes	2001
T52899	5180-5184	1473152	denotes	1992
T54083	5200-5204	8449404	denotes	1993
T45939	5281-5285	7588057	denotes	1995
T6949	5565-5569	1473152	denotes	1992
T43422	5571-5575	8125260	denotes	1994
T12254	5591-5595	8449404	denotes	1993
T38266	5613-5617	8202545	denotes	1994
T65157	6354-6358	8125260	denotes	1994
T83926	6376-6380	8202545	denotes	1994
T93053	6482-6486	8125260	denotes	1994
T24922	6504-6508	8202545	denotes	1994
T34242	6871-6875	7588057	denotes	1995
T30557	7548-7552	4642991	denotes	1972
T91483	7568-7572	6220621	denotes	1983
T87010	7598-7602	11023864	denotes	2000
T66209	7619-7623	12559495	denotes	2003
T6130	8563-8567	13654621	denotes	1959
T2876	12980-12984	5956248	denotes	1966
T29139	14936-14940	13654621	denotes	1959
T31415	15738-15742	13654621	denotes	1959
T49936	20549-20553	24539711	denotes	1951
T45512	20561-20565	13654621	denotes	1959
T81011	20583-20587	489953	denotes	1979
T15709	21037-21041	9693034	denotes	1998
T43472	22115-22119	9693034	denotes	1998
T40911	22331-22335	9503012	denotes	1998
T49725	22451-22455	9693034	denotes	1998
T90945	22473-22477	12175500	denotes	2002
T8080	22845-22849	1376319	denotes	1992
T27645	24362-24366	9693034	denotes	1998
T67049	29845-29849	781177	denotes	1976
T39522	30786-30790	11089928	denotes	2000
T71980	30816-30820	11023864	denotes	2000
T14086	30834-30838	11401392	denotes	2001
T24851	30858-30862	12586060	denotes	2003
T13078	30879-30883	12559495	denotes	2003
T16217	33189-33193	11023864	denotes	2000
T27994	33207-33211	11401392	denotes	2001
T19501	33231-33235	12586060	denotes	2003
T25180	33252-33256	12559495	denotes	2003
T74039	33864-33868	10686603	denotes	2000
T14949	33900-33904	10686603	denotes	2000
T41736	34007-34011	9916792	denotes	1999
T17681	36241-36245	12560810	denotes	2003
T72218	38725-38729	10431194	denotes	1999
T16759	41650-41654	11352264	denotes	2001
T67028	41872-41876	11063699	denotes	2000
T4817	42164-42168	9693034	denotes	1998
T78537	42183-42187	11118889	denotes	2001
T43597	42206-42210	12374769	denotes	2002
T38490	42224-42228	12412015	denotes	2002
T88434	42242-42246	12666195	denotes	2003
T74339	43058-43062	11559848	denotes	2001
T15308	43158-43162	12374769	denotes	2002
T32618	43176-43180	12412015	denotes	2002
T92387	43194-43198	12666195	denotes	2003
T15261	43408-43412	9693034	denotes	1998
T25076	43610-43614	3989825	denotes	1985
T77501	43921-43925	1619638	denotes	1992
T34635	43941-43945	8950682	denotes	1996
T3233	43963-43967	9546838	denotes	1998
T70122	43984-43988	10955485	denotes	2000
T57391	44294-44298	8205327	denotes	1994
T36001	44432-44436	13654621	denotes	1959
T91162	44547-44551	9676189	denotes	1998
T39299	45659-45663	11148447	denotes	2001
T6389	47322-47326	9374397	denotes	1997
T79404	47328-47332	9636085	denotes	1998
T15242	47344-47348	11017806	denotes	2000
T53983	47363-47367	11106354	denotes	2000
T15933	47389-47393	11137991	denotes	2001
T53460	48073-48077	8684466	denotes	1996
T23024	48118-48122	7885472	denotes	1995
T39161	48554-48558	9362463	denotes	1997
T1447	48574-48578	9463360	denotes	1998
T84663	48833-48837	7585966	denotes	1995
T8856	48852-48856	7501017	denotes	1995
T98636	48871-48875	9362463	denotes	1997
T54739	48890-48894	9199358	denotes	1997
T26592	48910-48914	9463360	denotes	1998
T81941	48933-48937	12455631	denotes	2002
T19075	49166-49170	9409672	denotes	1997
T17053	49187-49191	9108362	denotes	1997
T53896	49324-49328	7585966	denotes	1995
T93804	49343-49347	9362463	denotes	1997
T59441	49363-49367	9463360	denotes	1998
T52288	49465-49469	8684466	denotes	1996
T44539	49484-49488	9362463	denotes	1997
T74279	49503-49507	9199358	denotes	1997
T19781	49640-49644	9409672	denotes	1997
T45236	49661-49665	9108362	denotes	1997
T38996	49681-49685	10837030	denotes	2000
T51426	49853-49857	7885472	denotes	1995
T14969	49873-49877	8684466	denotes	1996
T73550	51263-51267	9409672	denotes	1997
T91787	51269-51273	10837120	denotes	2000
T44919	51290-51294	9108362	denotes	1997
T6564	51310-51314	10837030	denotes	2000
T18378	51354-51358	9409672	denotes	1997
T78045	51360-51364	10837120	denotes	2000
T27101	51409-51413	9409672	denotes	1997
T88287	51430-51434	9108362	denotes	1997
T4989	51799-51803	7889567	denotes	1995
T75351	51821-51825	8548816	denotes	1996
T64302	51840-51844	8674413	denotes	1996
T69447	51861-51865	9409672	denotes	1997
T50326	51867-51871	10837120	denotes	2000
T86561	52666-52670	4642991	denotes	1972
T25548	52686-52690	6220621	denotes	1983
T21422	52716-52720	11023864	denotes	2000
T12096	52737-52741	12559495	denotes	2003
T65500	53325-53329	10769239	denotes	2000
T83892	60191-60195	10716450	denotes	2000
T86133	60800-60804	8231863	denotes	1993
T70459	62374-62378	10686603	denotes	2000

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T98	13-23	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	Patterning
T99	31-36	NCBITaxon:10088	denotes	Mouse
T100	37-41	UBERON:0010166	denotes	Coat
T101	45-50	PR_EXT:000016145	denotes	Tbx15
T102	121-127	NCBITaxon:33208	denotes	animal
T103	128-135	NCBITaxon:kingdom	denotes	kingdom
T104	144-148	UBERON:0010166	denotes	coat
T105	152-156	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T106	239-246	GO:0065007	denotes	control
T107	271-283	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T108	317-322	NCBITaxon:10088	denotes	mouse
T109	323-331	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T110	340-343	UBERON:0001690	denotes	ear
T111	372-376	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T112	417-424	GO:0065007	denotes	control
T113	432-438	PR_EXT:000004372	denotes	Agouti
T114	439-443	SO_EXT:0000704	denotes	gene
T115	445-449	NCBITaxon:10088	denotes	Mice
T116	463-469	PR_EXT:000004372	denotes	Agouti
T117	470-476	SO_EXT:0001023	denotes	allele
T118	548-552	UBERON:0001037	denotes	hair
T119	572-576	UBERON:0001037	denotes	hair
T120	586-594	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T121	606-618	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T122	704-705	CHEBI_SO_EXT:base	denotes	b
T123	706-714	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T125	765-770	PR_EXT:000016145	denotes	Tbx15
T126	771-775	SO_EXT:0000704	denotes	gene
T127	783-792	UBERON:0000922	denotes	embryonic
T128	793-803	GO:0010467	denotes	expression
T129	818-828	UBERON:0003104	denotes	mesenchyme
T130	845-855	CHEBI_EXT:26130	denotes	pigmentary
T131	860-868	UBERON:0004288	denotes	skeletal
T132	903-910	NCBITaxon:33208	denotes	animals
T133	939-945	SO_EXT:0001023	denotes	allele
T134	949-954	PR_EXT:000016145	denotes	Tbx15
T135	1002-1007	PR_EXT:000016145	denotes	Tbx15
T136	1032-1041	UBERON:0000922	denotes	embryonic
T137	1042-1052	GO:0010467	denotes	expression
T138	1056-1061	PR_EXT:000016145	denotes	Tbx15
T139	1072-1082	UBERON:0003104	denotes	mesenchyme
T140	1103-1109	PR_EXT:000004372	denotes	Agouti
T141	1110-1120	GO:0010467	denotes	expression
T142	1124-1142	UBERON:2000164	denotes	ventral mesenchyme
T143	1162-1167	PR_EXT:000016145	denotes	Tbx15
T144	1169-1179	GO:0010467	denotes	expression
T145	1183-1189	PR_EXT:000004372	denotes	Agouti
T146	1198-1205	UBERON:0000922	denotes	embryos
T147	1214-1219	GO:0007567	denotes	natal
T148	1220-1227	NCBITaxon:33208	denotes	animals
T149	1323-1327	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T150	1356-1368	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T151	1426-1441	UBERON:0019248	denotes	early embryonic
T152	1442-1452	GO:0010467	denotes	expression
T153	1456-1461	PR_EXT:000016145	denotes	Tbx15
T154	1511-1523	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T155	1581-1587	UBERON_EXT:skin_or_dermis	denotes	dermal
T156	1588-1592	CL_GO_EXT:cell	denotes	cell
T157	1631-1635	UBERON:0002101	denotes	limb
T158	1659-1668	UBERON:0000922	denotes	Embryonic
T159	1669-1679	GO:0010467	denotes	expression
T160	1683-1688	PR_EXT:000016145	denotes	Tbx15
T161	1705-1715	UBERON:0003104	denotes	mesenchyme
T162	1809-1815	UBERON:0002067	denotes	dermis
T163	1865-1869	SO_EXT:0000704	denotes	gene
T164	1880-1889	UBERON:0000922	denotes	embryonic
T165	1880-1901	GO:0009790	denotes	embryonic development
T166	1962-1972	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterning
T167	2010-2017	NCBITaxon:40674	denotes	mammals
T168	2104-2108	UBERON_EXT:body	denotes	body
T793	2318-2325	CHEBI_GO_EXT:biological_process_or_quality_or_role	denotes	biology
T794	2357-2367	NCBITaxon:7742	denotes	vertebrate
T795	2368-2372	UBERON_EXT:body	denotes	body
T796	2466-2470	UBERON_EXT:body	denotes	body
T797	2517-2535	GO_EXT:cell_communication_or_signaling_or_signal_transduction	denotes	signaling pathways
T798	2553-2560	NCBITaxon:33208	denotes	animals
T799	2645-2652	GO:0065007	denotes	control
T800	2679-2683	UBERON_EXT:body	denotes	body
T801	2712-2723	NCBITaxon:7742	denotes	vertebrates
T802	2763-2780	UBERON:0004765	denotes	skeletal elements
T803	2804-2813	UBERON:0007376	denotes	epidermal
T804	2814-2824	UBERON:0004529	denotes	appendages
T805	2843-2850	CHEBI_EXT:26130	denotes	pigment
T806	2922-2928	NCBITaxon:33208	denotes	animal
T807	2956-2963	CHEBI_EXT:26130	denotes	pigment
T808	3083-3087	UBERON_EXT:body	denotes	body
T809	3097-3104	NCBITaxon:species	denotes	species
T810	3123-3130	NCBITaxon:33208	denotes	animals
T811	3152-3159	NCBITaxon:species	denotes	species
T812	3304-3311	CHEBI_EXT:26130	denotes	pigment
T813	3490-3500	NCBITaxon:7742	denotes	vertebrate
T814	3501-3509	OBI_SO_EXT:gene_or_genetic_investigation_or_genetic_process	denotes	genetics
T815	3572-3582	CHEBI_EXT:26130	denotes	pigmentary
T816	3649-3657	CL_GO_EXT:cell	denotes	cellular
T817	3661-3666	UBERON:0000062	denotes	organ
T818	3783-3793	NCBITaxon:7742	denotes	vertebrate
T819	3794-3806	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T820	3815-3821	UBERON:0000922	denotes	embryo
T821	3859-3868	GO_EXT:biological_movement_or_translocation_process	denotes	migration
T822	3872-3884	CL:0000541	denotes	melanoblasts
T823	3894-3906	UBERON:0002342	denotes	neural crest
T824	3944-3951	CHEBI_EXT:26130	denotes	pigment
T825	3944-3957	CL:0000147	denotes	pigment cells
T826	3952-3957	CL_GO_EXT:cell	denotes	cells
T827	3965-3969	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T828	4010-4024	UBERON:0002073	denotes	hair follicles
T829	4026-4035	GO:0038001	denotes	paracrine
T830	4044-4051	GO:0065007	denotes	control
T831	4064-4071	CHEBI_EXT:26130	denotes	pigment
T832	4104-4108	UBERON_EXT:body	denotes	body
T833	4141-4145	UBERON:0001037	denotes	hair
T834	4141-4151	GO:0042633	denotes	hair cycle
T835	4216-4244	GO:0051904	denotes	movement of pigment granules
T836	4228-4235	CHEBI_EXT:26130	denotes	pigment
T837	4228-4244	GO:0048770	denotes	pigment granules
T838	4252-4263	CL:0000148	denotes	melanocytes
T839	4272-4283	CL:0000148	denotes	melanocytes
T840	4287-4300	CL:0000312	denotes	keratinocytes
T841	4314-4322	CL_GO_EXT:cell	denotes	cellular
T842	4364-4368	CL_GO_EXT:cell	denotes	cell
T843	4422-4426	UBERON_EXT:body	denotes	body
T844	4517-4524	CHEBI_EXT:26130	denotes	pigment
T845	4545-4555	GO:0042470	denotes	melanosome
T846	4545-4566	GO:1903232	denotes	melanosome biogenesis
T847	4607-4616	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T848	4660-4667	GO:0065007	denotes	control
T849	4732-4743	NCBITaxon:7742	denotes	vertebrates
T850	4833-4837	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T851	4839-4845	UBERON:0002542	denotes	scales
T852	4847-4855	UBERON:0000022	denotes	feathers
T853	4860-4864	UBERON:0001037	denotes	hair
T854	4973-4978	UBERON:0002101	denotes	limbs
T855	4983-4990	NCBITaxon:9989	denotes	rodents
T856	5010-5017	NCBITaxon:40674	denotes	mammals
T857	5051-5055	UBERON:0001037	denotes	hair
T858	5097-5104	CHEBI_EXT:26130	denotes	pigment
T859	5127-5134	SO_EXT:0001023	denotes	allelic
T860	5135-5144	SO_EXT:sequence_variation_entity_or_quality	denotes	variation
T861	5152-5158	PR_EXT:000004372	denotes	Agouti
T862	5159-5163	SO_EXT:0000704	denotes	gene
T863	5207-5215	GO:0046903	denotes	Secreted
T864	5219-5233	UBERON:0000412	denotes	dermal papilla
T865	5219-5239	CL:0000346	denotes	dermal papilla cells
T866	5234-5239	CL_GO_EXT:cell	denotes	cells
T867	5252-5265	UBERON:0002073	denotes	hair follicle
T868	5288-5294	PR_EXT:000004372	denotes	Agouti
T869	5295-5302	CHEBI_PR_EXT:protein	denotes	protein
T870	5310-5321	CL:0000148	denotes	melanocytes
T871	5330-5338	UBERON_EXT:follicle	denotes	follicle
T872	5384-5393	CHEBI:24009	denotes	eumelanin
T873	5408-5419	CHEBI:81393	denotes	pheomelanin
T874	5421-5427	PR_EXT:000004372	denotes	Agouti
T875	5428-5435	CHEBI_PR_EXT:protein	denotes	protein
T876	5538-5542	UBERON:0001037	denotes	hair
T877	5538-5548	GO:0042633	denotes	hair cycle
T878	5630-5639	GO:0065007	denotes	regulated
T879	5640-5650	GO:0010467	denotes	expression
T880	5731-5735	NCBITaxon:10088	denotes	mice
T881	5768-5774	SO_EXT:0001023	denotes	allele
T882	5794-5802	UBERON:2002284	denotes	markings
T883	5814-5818	UBERON:0002387	denotes	feet
T884	5820-5824	UBERON:0001690	denotes	ears
T885	5829-5833	UBERON:0000033	denotes	head
T886	5855-5859	UBERON:0000033	denotes	head
T887	5860-5865	UBERON:2002283	denotes	spots
T888	5878-5881	NCBITaxon:9615	denotes	dog
T889	5904-5908	NCBITaxon:10088	denotes	mice
T890	5980-5986	PR_EXT:000004372	denotes	Agouti
T891	5987-5991	CHEBI_SO_EXT:mRNA	denotes	mRNA
T892	5992-6000	SO_EXT:0001060	denotes	isoforms
T893	6032-6047	GO_EXT:transcription	denotes	transcriptional
T894	6032-6063	SO_EXT:0000315	denotes	transcriptional initiation site
T895	6068-6089	SO_EXT:0000445	denotes	5′ untranslated exons
T896	6073-6083	GO:0006412	denotes	translated
T897	6094-6098	UBERON:0001037	denotes	hair
T898	6094-6104	GO:0042633	denotes	hair cycle
T899	6115-6125	SO_EXT:0000673	denotes	transcript
T900	6129-6138	GO:0010467	denotes	expressed
T901	6166-6170	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T902	6197-6201	UBERON:0001037	denotes	hair
T903	6202-6208	GO_EXT:biological_growth_entity_or_process	denotes	growth
T904	6237-6247	SO_EXT:0000673	denotes	transcript
T905	6251-6260	GO:0010467	denotes	expressed
T906	6300-6304	UBERON:0001037	denotes	hair
T907	6305-6311	GO_EXT:biological_growth_entity_or_process	denotes	growth
T908	6333-6337	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T909	6383-6390	NCBITaxon:33208	denotes	Animals
T910	6407-6413	SO_EXT:0001023	denotes	allele
T911	6414-6421	GO:0010467	denotes	express
T912	6448-6454	PR_EXT:000004372	denotes	Agouti
T913	6455-6465	SO_EXT:0000673	denotes	transcript
T914	6532-6537	UBERON:0001037	denotes	hairs
T915	6574-6579	UBERON:0001037	denotes	hairs
T916	6623-6627	UBERON:0002101	denotes	limb
T917	6628-6637	UBERON:0000309	denotes	body wall
T918	6638-6651	UBERON:0004905	denotes	articulations
T919	6677-6684	UBERON:0006378	denotes	whisker
T920	6685-6688	UBERON:2001977	denotes	pad
T921	6707-6713	PR_EXT:000004372	denotes	Agouti
T922	6714-6722	SO_EXT:0001060	denotes	isoforms
T923	6732-6741	GO:0010467	denotes	expressed
T924	6756-6760	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T925	6766-6775	UBERON:0000922	denotes	embryonic
T926	6827-6834	CHEBI_EXT:26130	denotes	pigment
T927	6827-6839	CL:0000147	denotes	pigment cell
T928	6835-6839	CL_GO_EXT:cell	denotes	cell
T929	6835-6855	GO:0030154	denotes	cell differentiation
T930	6884-6894	GO:0065007	denotes	regulatory
T931	6884-6903	SO_EXT:0005836	denotes	regulatory elements
T932	6925-6931	PR_EXT:000004372	denotes	Agouti
T933	6932-6940	SO_EXT:0001060	denotes	isoforms
T934	7007-7013	UBERON:0000922	denotes	embryo
T935	7046-7051	GO:0007567	denotes	birth
T936	7121-7125	NCBITaxon:10088	denotes	mice
T937	7207-7214	NCBITaxon:40674	denotes	mammals
T938	7220-7233	GO:0009653	denotes	morphogenetic
T939	7273-7277	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T940	7332-7339	CHEBI_EXT:26130	denotes	pigment
T941	7348-7361	UBERON:0002073	denotes	hair follicle
T942	7348-7373	CL:0002483	denotes	hair follicle melanocytes
T943	7390-7396	UBERON:0002067	denotes	dermis
T944	7404-7409	UBERON:0000180	denotes	flank
T945	7445-7455	UBERON:0004016	denotes	dermatomal
T946	7471-7478	UBERON:0002329	denotes	somites
T947	7483-7499	UBERON:0007529	denotes	loose mesenchyme
T948	7517-7539	UBERON:0003081	denotes	lateral plate mesoderm
T988	9147-9152	UBERON:0000180	denotes	flank
T989	9227-9237	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterning
T990	9275-9282	NCBITaxon:40674	denotes	mammals
T991	9368-9372	UBERON_EXT:body	denotes	body
T2428	9436-9440	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	Skin
T2429	9483-9487	UBERON:0001037	denotes	hair
T2430	9544-9548	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T2431	9614-9618	UBERON:0001037	denotes	hair
T2432	9643-9647	UBERON:0001037	denotes	hair
T2433	9658-9662	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T2434	9715-9727	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T2435	9775-9789	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T2436	9799-9806	CHEBI_EXT:26130	denotes	pigment
T2437	9799-9812	CL:0000147	denotes	pigment cells
T2438	9807-9812	CL_GO_EXT:cell	denotes	cells
T2439	9837-9844	CHEBI_EXT:26130	denotes	pigment
T2440	9860-9868	GO_EXT:reaction_or_response	denotes	response
T2441	9872-9882	GO:0010467	denotes	expression
T2442	9886-9892	PR_EXT:000004372	denotes	Agouti
T2443	9917-9921	UBERON:0001037	denotes	hair
T2444	9931-9938	NCBITaxon:33208	denotes	animals
T2445	10150-10154	NCBITaxon:10088	denotes	mice
T2446	10168-10174	PR_EXT:000004372	denotes	Agouti
T2447	10175-10184	SO_EXT:genotype_or_entity_with_genotype	denotes	genotypes
T2448	10219-10223	UBERON:0001037	denotes	hair
T2449	10345-10352	CHEBI_EXT:26130	denotes	pigment
T2450	10375-10379	NCBITaxon:10088	denotes	mice
T2451	10425-10429	UBERON:0001037	denotes	hair
T2452	10440-10444	UBERON:0001037	denotes	hair
T2453	10505-10511	UBERON:0001137	denotes	dorsum
T2454	10515-10522	UBERON:0013235	denotes	ventrum
T2455	10536-10541	UBERON:0000180	denotes	flank
T2456	10542-10547	UBERON:0001037	denotes	hairs
T2457	10559-10563	NCBITaxon:10088	denotes	mice
T2458	10627-10638	CHEBI:81393	denotes	pheomelanin
T2459	10694-10698	UBERON:0001037	denotes	hair
T2460	10738-10742	UBERON:0001037	denotes	hair
T2461	10788-10800	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T2462	10820-10826	PR_EXT:000004372	denotes	Agouti
T2463	10827-10835	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T2464	10846-10850	UBERON:0001037	denotes	hair
T2465	10846-10856	GO:0042633	denotes	hair-cycle
T2466	10925-10929	UBERON:0001037	denotes	hair
T2467	10941-10945	NCBITaxon:10088	denotes	mice
T2468	11059-11063	UBERON:0001037	denotes	hair
T2469	11075-11082	NCBITaxon:33208	denotes	animals
T2470	11111-11117	PR_EXT:000004372	denotes	Agouti
T2471	11118-11126	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T2472	11168-11172	UBERON_EXT:body	denotes	body
T2473	11262-11266	UBERON:0001037	denotes	hair
T2474	11349-11353	UBERON:0001037	denotes	hair
T2475	11349-11360	GO:0042633	denotes	hair cycles
T2476	11383-11387	UBERON:0001037	denotes	hair
T2477	11431-11438	CHEBI_EXT:26130	denotes	pigment
T2478	11464-11468	NCBITaxon:10088	denotes	mice
T2479	12635-12639	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T2480	12691-12695	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T2481	12703-12708	GO:0007567	denotes	natal
T2482	12739-12753	UBERON:0002073	denotes	hair follicles
T2483	12802-12816	UBERON:0002073	denotes	hair follicles
T2484	12864-12870	UBERON_EXT:skin_or_dermis	denotes	dermal
T2485	12918-12922	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T2486	13029-13033	UBERON:0001037	denotes	hair
T2487	13059-13064	UBERON:0001137	denotes	dorsa
T2488	13069-13075	UBERON:0013235	denotes	ventra
T2489	13079-13084	UBERON:0007023	denotes	adult
T2490	13085-13089	NCBITaxon:10088	denotes	mice
T2491	13113-13117	NCBITaxon:10088	denotes	mice
T2492	13174-13179	UBERON:0001037	denotes	hairs
T2493	13181-13188	UBERON:0010513	denotes	zigzags
T2494	13202-13207	UBERON:0001037	denotes	hairs
T2495	13209-13217	UBERON:0010510	denotes	auchenes
T2496	13219-13223	UBERON:0010511	denotes	awls
T2497	13229-13240	UBERON:0010512	denotes	guard hairs
T2498	13245-13251	UBERON:0001137	denotes	dorsum
T2499	13264-13271	UBERON:0013235	denotes	ventrum
T2500	13327-13331	UBERON:0001037	denotes	hair
T2501	13362-13366	NCBITaxon:10088	denotes	mice
T2502	13424-13436	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T2503	13446-13450	NCBITaxon:10088	denotes	mice
T2504	13477-13484	CHEBI_EXT:26130	denotes	pigment
T2505	13529-13539	GO:0010467	denotes	expression
T2506	13543-13549	PR_EXT:000004372	denotes	Agouti
T2507	13555-13562	NCBITaxon:33208	denotes	animals
T2508	13580-13584	SO_EXT:sequence_nullness	denotes	null
T2509	13585-13591	SO_EXT:0001023	denotes	allele
T2510	13595-13601	PR_EXT:000004372	denotes	Agouti
T2511	13640-13645	UBERON:0001037	denotes	hairs
T2512	13664-13671	CHEBI:25179	denotes	melanin
T2513	13684-13689	UBERON:0001037	denotes	hairs
T2514	13741-13745	UBERON:0010166	denotes	coat
T2515	13765-13769	CHEBI:49168	denotes	DOPA
T2516	13798-13808	GO_PR_EXT:monophenol_monooxygenase_or_tyrosinase	denotes	tyrosinase
T2517	13877-13883	UBERON:0002067	denotes	dermis
T2518	13913-13917	NCBITaxon:10088	denotes	mice
T2519	13944-13948	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T2520	13960-13964	NCBITaxon:10088	denotes	mice
T2521	14009-14013	CHEBI:49168	denotes	DOPA
T2522	14080-14087	CHEBI:25179	denotes	melanin
T2523	14109-14113	NCBITaxon:10088	denotes	mice
T2524	14119-14133	GO_EXT:negative_regulation	denotes	downregulation
T2525	14137-14147	GO_PR_EXT:monophenol_monooxygenase_or_tyrosinase	denotes	tyrosinase
T2526	14168-14174	PR_EXT:000004372	denotes	Agouti
T2527	14176-14183	CHEBI:25179	denotes	Melanin
T2528	14206-14211	UBERON:0001037	denotes	hairs
T2529	14261-14268	CHEBI_EXT:26130	denotes	pigment
T2530	14261-14274	CL:0000147	denotes	pigment cells
T2531	14269-14274	CL_GO_EXT:cell	denotes	cells
T2532	14285-14295	UBERON_EXT:follicle	denotes	follicular
T2533	14349-14353	UBERON:0001037	denotes	hair
T2534	14354-14361	CHEBI_EXT:26130	denotes	pigment
T2535	14379-14383	NCBITaxon:10088	denotes	mice
T2536	14412-14416	UBERON:0001037	denotes	hair
T2537	14412-14423	GO:0042633	denotes	hair cycles
T2538	14429-14438	UBERON:0000113	denotes	adulthood
T2539	14451-14455	UBERON:0001037	denotes	hair
T2540	14475-14479	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T2541	14561-14565	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T2542	14582-14589	CHEBI_EXT:26130	denotes	pigment
T2543	14619-14625	PR_EXT:000004372	denotes	Agouti
T2544	14626-14634	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T2545	14652-14656	UBERON:0001037	denotes	hair
T2546	14684-14691	CHEBI:25179	denotes	melanin
T3424	14720-14724	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	Skin
T3425	14750-14753	UBERON:0001690	denotes	ear
T3426	14754-14762	SO_EXT:sequence_alteration_entity_or_process	denotes	Mutation
T3427	14790-14802	UBERON_EXT:face_or_skull	denotes	craniofacial
T3428	14822-14825	UBERON:0001690	denotes	ear
T3429	14841-14849	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T3430	14853-14858	NCBITaxon:10088	denotes	mouse
T3431	14859-14869	GO_SO_EXT:chromosome	denotes	Chromosome
T3432	14886-14892	SO_EXT:0001023	denotes	allele
T3433	14974-14982	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T3434	15103-15115	UBERON_EXT:face_or_skull	denotes	craniofacial
T3435	15177-15184	NCBITaxon:33208	denotes	animals
T3436	15210-15214	UBERON:0000970	denotes	eyes
T3437	15222-15240	UBERON:0001819	denotes	palpebral fissures
T3438	15250-15255	UBERON:0000004	denotes	nasal
T3439	15278-15283	UBERON:0003129	denotes	skull
T3440	15385-15389	UBERON:0001690	denotes	ears
T3441	15422-15425	UBERON:0001690	denotes	ear
T3442	15447-15453	SO_EXT:0001023	denotes	allele
T3443	15478-15485	CHEBI_EXT:26130	denotes	pigment
T3444	15568-15575	SO_EXT:0000704	denotes	genetic
T3445	15595-15596	PR_EXT:000004372	denotes	A
T3446	15616-15621	UBERON:0000916	denotes	belly
T3447	15622-15626	UBERON:0001037	denotes	hair
T3448	15650-15654	UBERON:0011270	denotes	back
T3449	15655-15659	UBERON:0001037	denotes	hair
T3450	15665-15670	UBERON:0000916	denotes	belly
T3451	15671-15675	UBERON:0001037	denotes	hair
T3452	15716-15720	UBERON_EXT:body	denotes	body
T3453	15725-15729	UBERON:0001456	denotes	face
T3454	15770-15777	CHEBI_EXT:26130	denotes	pigment
T3455	15824-15828	NCBITaxon:10088	denotes	mice
T3456	15851-15857	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3457	15858-15865	NCBITaxon:33208	denotes	animals
T3458	15994-15999	UBERON:0001037	denotes	hairs
T3459	16073-16077	UBERON:0002101	denotes	limb
T3460	16078-16087	UBERON:0000309	denotes	body wall
T3461	16224-16228	NCBITaxon:10088	denotes	mice
T3462	16265-16270	UBERON:0001037	denotes	hairs
T3463	16316-16320	NCBITaxon:10088	denotes	mice
T3464	16366-16372	UBERON:2001463	denotes	stripe
T3465	16383-16388	UBERON:0000180	denotes	flank
T3466	16412-16416	NCBITaxon:10088	denotes	mice
T3467	16503-16508	UBERON:0000180	denotes	flank
T3468	16523-16532	CHEBI:24009	denotes	eumelanic
T3469	16604-16608	UBERON_EXT:body	denotes	body
T3470	16628-16634	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3471	16650-16656	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3472	16657-16664	NCBITaxon:33208	denotes	animals
T3473	16688-16692	UBERON_EXT:body	denotes	body
T3474	16741-16747	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3475	16748-16755	NCBITaxon:33208	denotes	animals
T3476	16909-16915	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3477	16940-16946	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3478	16947-16954	NCBITaxon:33208	denotes	animals
T3479	17027-17031	UBERON_EXT:body	denotes	body
T3480	17047-17052	UBERON:0002101	denotes	limbs
T3481	17061-17068	UBERON:1000019	denotes	cranium
T3482	17082-17089	UBERON:0006378	denotes	whisker
T3483	17090-17093	UBERON:2001977	denotes	pad
T3484	18507-18511	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T3485	18536-18543	CHEBI_EXT:26130	denotes	pigment
T3486	18587-18591	UBERON:0001037	denotes	hair
T3487	18603-18615	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T3488	18696-18700	UBERON:0001037	denotes	hair
T3489	18716-18722	UBERON:0001137	denotes	dorsum
T3490	18727-18734	UBERON:0013235	denotes	ventrum
T3491	18741-18747	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3492	18755-18761	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3493	18762-18769	NCBITaxon:33208	denotes	animals
T3494	18789-18793	UBERON_EXT:body	denotes	body
T3495	18817-18821	UBERON:0001037	denotes	hair
T3496	18902-18909	NCBITaxon:33208	denotes	animals
T3497	18918-18922	UBERON_EXT:body	denotes	body
T3498	18942-18950	UBERON:0004288	denotes	skeletal
T3499	18981-18985	UBERON:0010166	denotes	coat
T3500	19054-19062	PATO_UBERON_EXT:neonate_or_newborn	denotes	neonates
T3501	19119-19124	GO:0007567	denotes	birth
T3502	19158-19169	GO:0042438	denotes	melanogenic
T3503	19201-19205	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T3504	19234-19245	CL:0000541	denotes	melanoblast
T3505	19246-19255	GO_EXT:biological_movement_or_translocation_process	denotes	migration
T3506	19265-19277	UBERON:0002342	denotes	neural crest
T3507	19338-19348	CL:0000148	denotes	melanocyte
T3508	19349-19364	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T3509	19369-19376	CHEBI_EXT:26130	denotes	pigment
T3510	19369-19386	GO:0046148	denotes	pigment synthesis
T3511	19392-19396	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T3512	19406-19414	PATO_UBERON_EXT:neonate_or_newborn	denotes	neonates
T3513	19454-19460	UBERON:0001137	denotes	dorsum
T3514	19484-19492	PATO_UBERON_EXT:neonate_or_newborn	denotes	neonates
T3515	19498-19505	_FRAGMENT	denotes	area of
T3516	19511-19515	UBERON:0000014	denotes	skin
T3517	19559-19564	UBERON:0002101	denotes	limbs
T3518	19602-19611	CHEBI:24009	denotes	eumelanin
T3519	19630-19635	UBERON:0007023	denotes	adult
T3520	19636-19643	NCBITaxon:33208	denotes	animals
T3521	19717-19757	GO:0009953	denotes	establishment of dorsoventral patterning
T3522	19765-19769	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T3523	19765-19781	GO:0043588	denotes	skin development
T3524	19932-19936	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T3525	19951-19961	CL:0000148	denotes	melanocyte
T3526	19962-19977	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T3527	19992-20003	CHEBI:81393	denotes	pheomelanin
T3528	20059-20063	UBERON:0001037	denotes	hair
T3529	20064-20070	GO_EXT:biological_growth_entity_or_process	denotes	growth
T3530	20076-20083	UBERON:0013235	denotes	ventrum
T3531	20087-20093	UBERON:0001137	denotes	dorsum
T3532	20119-20123	SO_EXT:0000704	denotes	gene
T3533	20142-20147	PR_EXT:000016145	denotes	Tbx15
T3534	20161-20170	GO:0010467	denotes	expressed
T4501	20309-20316	SO_EXT:sequence_cloning_process	denotes	Cloning
T4502	20337-20343	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T4503	20392-20395	UBERON:0001690	denotes	ear
T4504	20396-20402	SO_EXT:0001023	denotes	allele
T4505	20414-20420	SO_EXT:0001023	denotes	allele
T4506	20464-20474	GO_SO_EXT:chromosome	denotes	Chromosome
T4507	20648-20652	NCBITaxon:10088	denotes	mice
T4508	20765-20774	NCBITaxon:2	denotes	bacterial
T4509	20765-20796	SO_EXT:0000153	denotes	bacterial artificial chromosome
T4510	20786-20796	GO_SO_EXT:chromosome	denotes	chromosome
T4511	20798-20801	SO_EXT:0000153	denotes	BAC
T4512	20803-20809	SO_EXT:0000149	denotes	contig
T4513	20825-20832	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T4514	20843-20844	CHEBI_SO_EXT:base	denotes	b
T4515	20873-20878	SO_EXT:0000704	denotes	genes
T4516	20890-20895	PR_EXT:000016145	denotes	Tbx15
T4517	20923-20928	PR_EXT:000016145	denotes	Tbx15
T4518	20963-20971	UBERON:0004288	denotes	skeletal
T4519	21062-21071	UBERON:0000922	denotes	embryonic
T4520	21072-21082	GO:0010467	denotes	expression
T4521	21090-21102	UBERON_EXT:face_or_skull	denotes	craniofacial
T4522	21125-21130	UBERON:0002101	denotes	limbs
T4523	22073-22081	SO_EXT:biological_sequence	denotes	sequence
T4524	22149-22154	NCBITaxon:10088	denotes	mouse
T4525	22155-22161	SO_EXT:0001026	denotes	genome
T4526	22162-22170	SO_EXT:biological_sequence	denotes	sequence
T4527	22186-22197	_FRAGMENT	denotes	portions of
T4528	22212-22217	SO_EXT:0000852	denotes	exons
T4529	22206-22211	PR_EXT:000016145	denotes	Tbx15
T4530	22254-22265	SO_EXT:genomic_DNA	denotes	genomic DNA
T4531	22262-22265	CHEBI_SO_EXT:DNA	denotes	DNA
T4532	22276-22280	SO_EXT:0000704	denotes	gene
T4533	22310-22314	PR_EXT:000016145	denotes	Tbx8
T4534	22360-22365	PR_EXT:000016145	denotes	Tbx14
T4535	22407-22417	NCBITaxon:7742	denotes	vertebrate
T4536	22418-22425	SO_EXT:0001026	denotes	genomes
T4537	22429-22434	PR_EXT:000016145	denotes	Tbx15
T4538	22497-22505	SO_EXT:biological_sequence	denotes	sequence
T4539	22516-22517	CHEBI_SO_EXT:base	denotes	b
T4540	22559-22570	SO_EXT:genomic_DNA	denotes	genomic DNA
T4541	22567-22570	CHEBI_SO_EXT:DNA	denotes	DNA
T4542	22593-22598	NCBITaxon:10088	denotes	mouse
T4543	22599-22605	SO_EXT:0001026	denotes	genome
T4544	22606-22614	SO_EXT:biological_sequence	denotes	sequence
T4545	22637-22638	CHEBI_SO_EXT:base	denotes	b
T4546	22639-22647	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T4547	22666-22671	PR_EXT:000016145	denotes	Tbx15
T4548	22672-22678	SO_EXT:0000188	denotes	intron
T4549	22689-22690	CHEBI_SO_EXT:base	denotes	b
T4550	22691-22701	SO_EXT:sequence_downstreamness	denotes	downstream
T4551	22709-22724	GO:0043631	denotes	polyadenylation
T4552	22709-22733	SO_EXT:0000610	denotes	polyadenylation sequence
T4553	22761-22780	CHEBI:17369	denotes	mannose-6-phosphate
T4554	22781-22789	GO_EXT:0004872	denotes	receptor
T4555	22790-22800	SO_EXT:0000336	denotes	pseudogene
T4556	22807-22809	SO_EXT:0000336	denotes	ps
T4557	22895-22901	SO_EXT:sequence_fusion_entity_or_process	denotes	fusion
T4558	22902-22912	SO_EXT:0000673	denotes	transcript
T4559	22935-22945	GO_SO_EXT:chromosome	denotes	chromosome
T4560	22977-22985	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T4561	23009-23020	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T4562	23021-23028	SO_EXT:sequence_coding_function	denotes	encoded
T4563	23032-23037	PR_EXT:000016145	denotes	Tbx15
T4564	23059-23062	CHEBI_SO_EXT:DNA	denotes	DNA
T4565	23063-23070	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T4566	23071-23077	SO_EXT:0000417	denotes	domain
T4567	23084-23085	SO_EXT:normal_or_wild_type_or_present	denotes	+
T4568	23086-23093	NCBITaxon:33208	denotes	animals
T4569	23143-23150	NCBITaxon:33208	denotes	animals
T4570	23199-23205	SO_EXT:0001023	denotes	allele
T4571	23236-23238	SO_EXT:0000336	denotes	ps
T4572	23249-23254	SO_EXT:0000704	denotes	genes
T4573	23258-23269	SO_EXT:0000673	denotes	transcripts
T4574	23302-23303	CHEBI_SO_EXT:base	denotes	b
T4575	23304-23312	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T4576	23335-23342	SO_EXT:sequence_cloning_process	denotes	cloning
T4577	23407-23415	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T4578	23419-23424	PR_EXT:000016145	denotes	Tbx15
T4579	23428-23432	SO_EXT:0000704	denotes	gene
T4580	23446-23455	UBERON:0000922	denotes	embryonic
T4581	23446-23466	CL:0002322	denotes	embryonic stem cells
T4582	23461-23466	CL_GO_EXT:cell	denotes	cells
T4583	23481-23487	SO_EXT:0001023	denotes	allele
T4584	23489-23494	PR_EXT:000016145	denotes	Tbx15
T4585	23494-23498	PR_EXT:000033987	denotes	LacZ
T4586	23511-23515	SO_EXT:0000243	denotes	IRES
T4587	23516-23520	PR_EXT:000033987	denotes	LacZ
T4588	23521-23524	CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase	denotes	neo
T4589	23525-23529	SO_EXT:cDNA	denotes	cDNA
T4590	23530-23538	SO_EXT:0005853	denotes	cassette
T4591	23557-23575	SO_EXT:0000236	denotes	open reading frame
T4592	23579-23584	SO_EXT:0000360	denotes	codon
T4593	23608-23614	SO_EXT:0000417	denotes	domain
T4594	23628-23635	NCBITaxon:33208	denotes	Animals
T4595	23666-23672	SO_EXT:0001023	denotes	allele
T4596	23716-23724	UBERON:0004288	denotes	skeletal
T4597	23741-23745	UBERON:0001037	denotes	hair
T4598	23770-23775	PR_EXT:000016145	denotes	Tbx15
T4599	23775-23779	PR_EXT:000033987	denotes	LacZ
T4600	23780-23785	PR_EXT:000016145	denotes	Tbx15
T4601	23785-23789	PR_EXT:000033987	denotes	LacZ
T4602	23832-23836	UBERON_EXT:body	denotes	body
T4603	23858-23870	UBERON_EXT:face_or_skull	denotes	craniofacial
T4604	23928-23933	PR_EXT:000016145	denotes	Tbx15
T4605	23933-23937	PR_EXT:000033987	denotes	LacZ
T4606	23996-24003	NCBITaxon:33208	denotes	animals
T4607	24054-24066	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T4608	24095-24100	UBERON:0000180	denotes	flank
T4609	24137-24144	NCBITaxon:33208	denotes	animals
T4610	24201-24211	CHEBI_EXT:26130	denotes	pigmentary
T4611	24216-24228	UBERON_EXT:face_or_skull	denotes	craniofacial
T4612	24287-24292	PR_EXT:000016145	denotes	Tbx15
T5363	24295-24305	GO:0010467	denotes	Expression
T5364	24309-24314	PR_EXT:000016145	denotes	Tbx15
T5365	24319-24325	PR_EXT:000004372	denotes	Agouti
T5366	24394-24407	GO:0097617	denotes	hybridization
T5367	24418-24428	GO:0010467	denotes	expression
T5368	24432-24437	PR_EXT:000016145	denotes	Tbx15
T5369	24473-24482	UBERON:0004347	denotes	limb buds
T5370	24503-24519	UBERON:0002539	denotes	branchial arches
T5371	24521-24527	UBERON:0000180	denotes	flanks
T5372	24533-24545	UBERON_EXT:face_or_skull	denotes	craniofacial
T5373	24616-24626	GO:0097617	denotes	hybridized
T5374	24629-24634	PR_EXT:000016145	denotes	Tbx15
T5375	24635-24639	CHEBI_SO_EXT:mRNA	denotes	mRNA
T5376	24640-24645	CHEBI_SO_EXT:molecular_probe	denotes	probe
T5377	24703-24713	GO:0010467	denotes	expression
T5378	24726-24748	_FRAGMENT	denotes	mesenchymal tissues of
T5379	24753-24757	UBERON:0005253	denotes	head
T5380	24759-24764	UBERON:0005256	denotes	trunk
T5381	24781-24786	UBERON:0009749	denotes	limbs
T5382	24837-24842	UBERON:0003129	denotes	skull
T5383	24844-24862	UBERON:0002413	denotes	cervical vertebrae
T5384	24868-24872	UBERON:0002101	denotes	limb
T5385	24900-24904	NCBITaxon:10088	denotes	mice
T5386	24934-24937	UBERON:0001690	denotes	ear
T5387	24938-24944	SO_EXT:0001023	denotes	allele
T5388	25809-25818	UBERON:0000922	denotes	embryonic
T5389	25819-25824	UBERON:0000180	denotes	flank
T5390	25825-25835	GO:0010467	denotes	expression
T5391	25891-25895	NCBITaxon:10088	denotes	mice
T5392	25908-25917	UBERON:0000916	denotes	abdominal
T5393	25997-26007	GO:0010467	denotes	expression
T5394	26027-26037	UBERON:0003104	denotes	mesenchyme
T5395	26154-26160	UBERON:0002067	denotes	dermis
T5396	26191-26207	UBERON:0007529	denotes	loose mesenchyme
T5397	26216-26225	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	cutaneous
T5398	26226-26238	UBERON:0018260	denotes	muscle layer
T5399	26240-26245	PR_EXT:000016145	denotes	Tbx15
T5400	26249-26258	GO:0010467	denotes	expressed
T5401	26308-26325	UBERON:0002378	denotes	abdominal muscles
T5402	26335-26339	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T5403	26341-26346	PR_EXT:000016145	denotes	Tbx15
T5404	26350-26359	GO:0010467	denotes	expressed
T5405	26387-26391	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T5406	26430-26436	UBERON:0002067	denotes	dermis
T5407	26452-26458	UBERON_EXT:skin_or_dermis	denotes	dermal
T5408	26459-26466	UBERON:0005933	denotes	sheaths
T5409	26470-26484	UBERON:0002073	denotes	hair follicles
T5410	26492-26502	GO:0010467	denotes	expression
T5411	26532-26547	UBERON:0000412	denotes	dermal papillae
T5412	26532-26553	CL:0000346	denotes	dermal papillae cells
T5413	26548-26553	CL_GO_EXT:cell	denotes	cells
T5414	26591-26597	PR_EXT:000004372	denotes	Agouti
T5415	26601-26608	CHEBI_EXT:26130	denotes	pigment
T5416	26641-26646	GO:0007567	denotes	natal
T5417	26647-26651	UBERON:0001037	denotes	hair
T5418	26652-26658	GO_EXT:biological_growth_entity_or_process	denotes	growth
T5419	26681-26688	SO_EXT:0001060	denotes	isoform
T5420	26692-26698	PR_EXT:000004372	denotes	Agouti
T5421	26702-26711	GO:0010467	denotes	expressed
T5422	26726-26730	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T5423	26781-26791	GO:0097617	denotes	hybridized
T5424	26797-26803	CHEBI_SO_EXT:molecular_probe	denotes	probes
T5425	26808-26813	PR_EXT:000016145	denotes	Tbx15
T5426	26818-26824	PR_EXT:000004372	denotes	Agouti
T5427	26876-26886	GO:0010467	denotes	expression
T5428	26890-26896	PR_EXT:000004372	denotes	Agouti
T5429	26908-26912	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T5430	26917-26927	GO:0010467	denotes	expression
T5431	26931-26936	PR_EXT:000016145	denotes	Tbx15
T5432	26947-26951	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T5433	26993-27003	GO:0010467	denotes	expression
T5434	27041-27046	PR_EXT:000016145	denotes	Tbx15
T5435	27047-27057	GO:0010467	denotes	expression
T5436	27106-27112	PR_EXT:000004372	denotes	Agouti
T5437	27113-27123	GO:0010467	denotes	expression
T5438	27689-27699	GO:0010467	denotes	expression
T5439	27703-27709	PR_EXT:000004372	denotes	Agouti
T5440	27742-27748	SO_EXT:sequence_altered_entity	denotes	mutant
T5441	27753-27762	SO_EXT:sequence_unaltered_entity	denotes	nonmutant
T5442	27859-27865	PR_EXT:000004372	denotes	Agouti
T5444	27921-27928	UBERON:0000922	denotes	embryos
T5445	27950-27954	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T5446	27956-27966	GO:0010467	denotes	expression
T5447	27970-27976	PR_EXT:000004372	denotes	Agouti
T5448	28014-28021	NCBITaxon:33208	denotes	animals
T5449	28083-28089	UBERON:0002067	denotes	dermis
T5450	28094-28109	UBERON:0000412	denotes	dermal papillae
T5451	28094-28115	CL:0000346	denotes	dermal papillae cells
T5452	28110-28115	CL_GO_EXT:cell	denotes	cells
T5453	28145-28157	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T5454	28179-28183	NCBITaxon:10088	denotes	mice
T5455	28243-28249	PR_EXT:000004372	denotes	Agouti
T5456	28250-28260	GO:0010467	denotes	expression
T5457	28267-28272	GO:0007567	denotes	birth
T5458	28274-28283	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterned
T5459	28284-28294	GO:0010467	denotes	expression
T5460	28298-28303	PR_EXT:000016145	denotes	Tbx15
T5461	28308-28314	PR_EXT:000004372	denotes	Agouti
T5462	28394-28399	PR_EXT:000016145	denotes	Tbx15
T5463	28414-28424	GO:0010467	denotes	expression
T5464	28428-28434	PR_EXT:000004372	denotes	Agouti
T6088	29105-29114	UBERON:0000922	denotes	Embryonic
T6089	29115-29120	PR_EXT:000016145	denotes	Tbx15
T6090	29121-29131	GO:0010467	denotes	Expression
T6091	29154-29166	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	Pigmentation
T6092	29255-29265	GO:0010467	denotes	expression
T6093	29269-29274	PR_EXT:000016145	denotes	Tbx15
T6094	29282-29291	UBERON:0000922	denotes	embryonic
T6095	29299-29304	UBERON:0000180	denotes	flank
T6096	29364-29370	UBERON:0002067	denotes	dermis
T6097	29397-29404	CHEBI_EXT:26130	denotes	pigment
T6098	29451-29457	PR_EXT:000004372	denotes	Agouti
T6099	29458-29465	SO_EXT:0001060	denotes	isoform
T6100	29569-29578	UBERON:0000922	denotes	embryonic
T6101	29579-29583	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6102	29654-29663	UBERON:0000922	denotes	embryonic
T6103	29664-29668	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6104	29725-29729	UBERON:0001037	denotes	hair
T6105	29751-29761	GO:0010467	denotes	expression
T6106	29765-29770	PR_EXT:000016145	denotes	Tbx15
T6107	29775-29781	PR_EXT:000004372	denotes	Agouti
T6108	29882-29886	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6109	29907-29914	UBERON:0000922	denotes	embryos
T6110	29946-29950	UBERON:0001037	denotes	hair
T6111	29989-29995	UBERON:0000473	denotes	testis
T6112	30051-30057	UBERON_EXT:skin_or_dermis	denotes	dermal
T6113	30058-30067	UBERON:0007376	denotes	epidermal
T6114	30171-30180	UBERON:0000922	denotes	embryonic
T6115	30181-30187	UBERON:0002067	denotes	dermis
T6116	30235-30244	UBERON:0000922	denotes	embryonic
T6117	30245-30249	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6118	30260-30267	UBERON:0000922	denotes	embryos
T6119	30281-30286	UBERON:0000180	denotes	flank
T6120	30391-30395	UBERON:0001037	denotes	hair
T6121	30402-30408	UBERON:0000473	denotes	testis
T6122	30448-30452	SO_EXT:0000704	denotes	gene
T6123	30448-30463	GO:0010467	denotes	gene expression
T6124	30478-30491	GO:0097617	denotes	hybridization
T6125	30561-30566	UBERON:0000180	denotes	flank
T6126	30580-30584	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6127	30606-30610	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6128	30645-30650	UBERON:0000180	denotes	flank
T6129	30651-30655	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6130	30675-30685	UBERON:0000924	denotes	ectodermal
T6131	30749-30756	UBERON:0003082	denotes	myotome
T6132	31648-31657	UBERON:0000922	denotes	embryonic
T6133	31666-31670	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6134	31690-31694	UBERON:0001037	denotes	hair
T6135	31720-31726	UBERON:0000473	denotes	testis
T6136	31756-31760	UBERON:0001037	denotes	hair
T6137	31770-31774	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6138	31795-31799	UBERON:0001037	denotes	hair
T6139	31820-31824	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6140	31844-31848	UBERON:0001037	denotes	hair
T6141	31877-31882	UBERON:0000180	denotes	flank
T6142	31883-31887	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6143	31919-31923	UBERON:0001037	denotes	hair
T6144	31960-31964	UBERON:0001037	denotes	hair
T6145	32025-32030	UBERON:0000180	denotes	flank
T6146	32070-32074	UBERON:0001037	denotes	hair
T6147	32136-32141	UBERON:0001037	denotes	hairs
T6148	32183-32189	UBERON:0000479	denotes	tissue
T6149	32236-32245	GO:0010467	denotes	expressed
T6150	32246-32251	PR_EXT:000016145	denotes	Tbx15
T6151	32260-32266	PR_EXT:000004372	denotes	Agouti
T6152	32274-32279	UBERON:0000180	denotes	flank
T6153	32287-32296	GO:0010467	denotes	expressed
T6154	32302-32307	SO_EXT:0000704	denotes	genes
T6155	32362-32374	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T6156	32407-32416	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterned
T6157	32417-32427	GO:0010467	denotes	expression
T6158	32449-32454	PR_EXT:000016145	denotes	Tbx15
T6159	32459-32465	PR_EXT:000004372	denotes	Agouti
T6160	32555-32559	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6161	32555-32571	GO:0043588	denotes	skin development
T6162	32585-32595	GO:0010467	denotes	expression
T6163	32599-32604	PR_EXT:000016145	denotes	Tbx15
T6164	32651-32655	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6799	32691-32698	CHEBI_EXT:26130	denotes	Pigment
T6800	32748-32764	UBERON:0015178	denotes	Somitic Frontier
T6801	32769-32779	UBERON:0000924	denotes	ectodermal
T6802	32828-32837	UBERON:0000922	denotes	embryonic
T6803	32838-32844	UBERON:0001137	denotes	dorsum
T6804	32849-32858	UBERON:0000922	denotes	embryonic
T6805	32859-32864	UBERON:0000180	denotes	flank
T6806	32896-32906	NCBITaxon:7742	denotes	vertebrate
T6807	32907-32914	UBERON:0000922	denotes	embryos
T6808	32919-32923	CL_GO_EXT:cell	denotes	cell
T6809	32959-32964	NCBITaxon_UBERON_EXT:chick	denotes	chick
T6810	33029-33035	UBERON:0002067	denotes	dermis
T6811	33049-33065	UBERON:0003077	denotes	somitic mesoderm
T6812	33070-33076	UBERON:0002067	denotes	dermis
T6813	33090-33112	UBERON:0003081	denotes	lateral plate mesoderm
T6814	33146-33162	UBERON:0015178	denotes	somitic frontier
T6815	33318-33327	NCBITaxon:40674	denotes	mammalian
T6816	33328-33335	UBERON:0000922	denotes	embryos
T6817	33337-33343	UBERON:0002329	denotes	somite
T6818	33349-33362	UBERON:0003081	denotes	lateral plate
T6819	33371-33379	UBERON:0000926	denotes	mesoderm
T6820	33414-33420	UBERON:0002067	denotes	dermis
T6821	33447-33451	UBERON:0002101	denotes	limb
T6822	33452-33461	UBERON:0000309	denotes	body wall
T6823	33554-33566	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T6824	33596-33606	UBERON:0000924	denotes	ectodermal
T6825	33678-33690	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T6826	33704-33710	UBERON:0002067	denotes	dermis
T6827	33724-33746	UBERON:0003081	denotes	lateral plate mesoderm
T6828	33769-33778	SO_EXT:0000902	denotes	transgene
T6829	33793-33798	PR_EXT:000008703	denotes	Hoxb6
T6830	33799-33807	SO_EXT:0000167	denotes	promoter
T6831	33910-33919	GO:0007565	denotes	gestation
T6832	33920-33927	UBERON:0000922	denotes	embryos
T6833	33946-33951	PR_EXT:000008703	denotes	Hoxb6
T6834	33956-33965	SO_EXT:0000902	denotes	transgene
T6835	33979-33983	PR_EXT:000033987	denotes	lacZ
T6836	33993-33997	SO_EXT:0000704	denotes	gene
T6837	34021-34026	CHEBI:75055	denotes	X-Gal
T6838	34039-34061	UBERON:0003081	denotes	lateral plate mesoderm
T6839	34070-34093	UBERON:0003077	denotes	somite-derived mesoderm
T6840	34101-34106	UBERON:0002100	denotes	trunk
T6841	34123-34127	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6842	34159-34167	PATO_UBERON_EXT:neonate_or_newborn	denotes	neonatal
T6843	34168-34175	NCBITaxon:33208	denotes	animals
T6844	34212-34217	CHEBI:75055	denotes	X-Gal
T6845	34244-34257	UBERON:0003081	denotes	lateral plate
T6846	34266-34272	UBERON:0002067	denotes	dermis
T6847	34380-34384	NCBITaxon:10088	denotes	mice
T6848	34398-34409	CHEBI:81393	denotes	pheomelanin
T6849	34445-34449	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6850	34501-34505	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T6851	34539-34548	CHEBI:24009	denotes	eumelanin
T6852	34553-34559	UBERON:0002329	denotes	somite
T6853	34568-34574	UBERON:0002067	denotes	dermis
T6854	34650-34662	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T6855	34740-34753	UBERON:0003081	denotes	lateral plate
T6856	34759-34765	UBERON:0002329	denotes	somite
T6857	34774-34780	UBERON:0002067	denotes	dermis
T6858	35830-35842	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T6859	35878-35882	UBERON:0002101	denotes	limb
T6860	35883-35892	UBERON:0000309	denotes	body wall
T6861	35971-35975	UBERON:0002101	denotes	limb
T6862	35976-35986	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterning
T6863	36035-36047	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T6864	36076-36080	UBERON:0002101	denotes	limb
T6865	36082-36092	PR_EXT:000007070	denotes	Engrailed1
T6866	36094-36097	PR_EXT:000007070	denotes	En1
T6867	36100-36105	PR_EXT:000017448	denotes	Wnt7a
T6868	36111-36116	PR_EXT:000009871	denotes	Lmx1b
T6869	36167-36177	GO:0010467	denotes	expression
T6870	36248-36251	PR_EXT:000007070	denotes	En1
T6871	36267-36276	GO:0010467	denotes	expressed
T6872	36295-36300	UBERON:0000180	denotes	flank
T6873	36323-36332	UBERON:0000916	denotes	abdominal
T6874	36364-36375	UBERON:0001049	denotes	neural tube
T6875	36377-36402	UBERON:0003077	denotes	somite-derived mesenchyme
T6876	36412-36429	UBERON:0017648	denotes	ventral body wall
T6877	36463-36473	GO:0097617	denotes	hybridized
T6878	36479-36484	PR_EXT:000016145	denotes	Tbx15
T6879	36524-36529	UBERON:0000180	denotes	flank
T6880	36612-36624	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T6881	36650-36672	UBERON:0003081	denotes	lateral plate mesoderm
T6882	36736-36752	UBERON:0015178	denotes	somitic frontier
T7511	36774-36783	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T7512	36788-36793	SO_EXT:0000704	denotes	genes
T7513	36842-36855	UBERON:0002073	denotes	hair follicle
T7514	36842-36867	GO:0001942	denotes	hair follicle development
T7515	36873-36878	PR_EXT:000016145	denotes	Tbx15
T7516	36891-36895	SO_EXT:0000704	denotes	gene
T7517	36946-36950	UBERON:0001037	denotes	hair
T7518	36951-36963	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T7519	36977-36981	UBERON_EXT:body	denotes	body
T7520	37034-37038	UBERON:0001037	denotes	hair
T7521	37046-37051	UBERON:0002100	denotes	trunk
T7522	37053-37058	UBERON:0002101	denotes	limbs
T7523	37064-37076	UBERON_EXT:face_or_skull	denotes	craniofacial
T7524	37109-37113	NCBITaxon:10088	denotes	mice
T7525	37126-37131	UBERON:0002100	denotes	trunk
T7526	37173-37183	GO:0010467	denotes	expression
T7527	37190-37196	PR_EXT:000004372	denotes	Agouti
T7528	37197-37201	CHEBI_SO_EXT:mRNA	denotes	mRNA
T7529	37202-37209	SO_EXT:0001060	denotes	isoform
T7530	37249-37253	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T7531	37263-37269	SO_EXT:0001023	denotes	allele
T7532	37291-37299	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T7533	37325-37330	PR_EXT:000016145	denotes	Tbx15
T7534	37331-37346	SO_EXT:coding_sequence	denotes	coding sequence
T7535	37421-37426	PR_EXT:000016145	denotes	Tbx15
T7536	37473-37477	SO_EXT:0000704	denotes	gene
T7537	37546-37551	SO_EXT:0000704	denotes	genes
T7538	37579-37599	SO_EXT:0001415	denotes	deletion breakpoints
T7539	37609-37619	GO:0010467	denotes	expression
T7540	37631-37636	PR_EXT:000016145	denotes	Tbx15
T7541	37721-37727	SO_EXT:0001023	denotes	allele
T7542	37740-37746	SO_EXT:0001023	denotes	allele
T7543	37759-37764	PR_EXT:000016145	denotes	Tbx15
T7544	37774-37780	SO_EXT:0001023	denotes	allele
T7545	37837-37846	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterned
T7546	37847-37857	GO:0010467	denotes	expression
T7547	37861-37866	PR_EXT:000016145	denotes	Tbx15
T7548	37949-37955	UBERON:0002067	denotes	dermis
T7549	37971-37981	CHEBI_EXT:26130	denotes	pigmentary
T7550	37986-37990	UBERON:0001037	denotes	hair
T7551	37998-38008	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterning
T7552	38030-38035	PR_EXT:000016145	denotes	Tbx15
T7553	38036-38046	GO:0010467	denotes	expression
T7554	38065-38070	UBERON:0000180	denotes	flank
T7555	38133-38137	UBERON:0002101	denotes	limb
T7556	38133-38149	GO:0060173	denotes	limb development
T7557	38165-38187	UBERON:0003081	denotes	lateral plate mesoderm
T7558	38237-38241	SO_EXT:0000704	denotes	gene
T7559	38252-38261	UBERON:0000922	denotes	embryonic
T7560	38252-38273	GO:0009790	denotes	embryonic development
T7561	38391-38400	NCBITaxon:40674	denotes	mammalian
T7562	38401-38405	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T7906	38482-38488	GO:0007601	denotes	visual
T7907	38525-38529	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T7908	38539-38543	NCBITaxon:10088	denotes	mice
T7909	38663-38667	SO_EXT:0000704	denotes	gene
T7910	38663-38678	GO:0010467	denotes	gene expression
T7911	38683-38687	CL_GO_EXT:cell	denotes	cell
T7912	38741-38747	PR_EXT:000004372	denotes	Agouti
T7913	38748-38752	CHEBI_SO_EXT:mRNA	denotes	mRNA
T7914	38761-38770	UBERON:0000922	denotes	embryonic
T7915	38779-38784	GO:0007567	denotes	natal
T7916	38785-38789	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T7917	38932-38936	UBERON:0001037	denotes	hair
T7918	38975-38986	CL:0000148	denotes	melanocytes
T7919	39137-39141	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T7920	39151-39155	NCBITaxon:10088	denotes	mice
T7921	39222-39229	CHEBI_EXT:26130	denotes	pigment
T7922	39249-39256	CHEBI_EXT:26130	denotes	pigment
T7923	39311-39316	UBERON:0000180	denotes	flank
T7924	39355-39361	PR_EXT:000004372	denotes	Agouti
T7925	39362-39366	CHEBI_SO_EXT:mRNA	denotes	mRNA
T7926	39401-39408	UBERON:0013235	denotes	ventrum
T7927	39414-39418	UBERON:0001037	denotes	hair
T7928	39419-39426	CHEBI_EXT:26130	denotes	pigment
T7929	39492-39499	UBERON:0013235	denotes	ventrum
T7930	39527-39534	SO_EXT:0000704	denotes	genetic
T7931	39597-39602	UBERON:0000180	denotes	flank
T7932	40875-40880	PR_EXT:000016145	denotes	Tbx15
T7933	40917-40921	UBERON:0001037	denotes	hair
T7934	40930-40937	CHEBI_EXT:26130	denotes	pigment
T7935	40951-40961	GO:0010467	denotes	expression
T7936	40986-40992	PR_EXT:000004372	denotes	Agouti
T7937	40993-41000	SO_EXT:0001060	denotes	isoform
T7938	41095-41107	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T7939	41111-41116	UBERON:0007023	denotes	adult
T7940	41125-41129	NCBITaxon:10088	denotes	mice
T7941	41174-41178	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T7942	41182-41190	PATO_UBERON_EXT:neonate_or_newborn	denotes	neonatal
T7943	41199-41203	NCBITaxon:10088	denotes	mice
T7944	41251-41257	UBERON:0007023	denotes	adults
T7945	41324-41328	UBERON:0001037	denotes	hair
T8391	41343-41351	OBI_SO_EXT:gene_or_genetic_investigation_or_genetic_process	denotes	Genetics
T8392	41355-41360	PR_EXT:000016145	denotes	Tbx15
T8393	41389-41392	CHEBI_SO_EXT:DNA	denotes	DNA
T8394	41393-41400	CHEMINF_GO_EXT:chemical_binding_or_bond_formation	denotes	binding
T8395	41401-41407	SO_EXT:0000417	denotes	domain
T8396	41432-41437	NCBITaxon:10088	denotes	mouse
T8397	41438-41447	PR_EXT:000016001	denotes	Brachyury
T8398	41448-41452	SO_EXT:0000704	denotes	gene
T8399	41488-41492	UBERON:0002415	denotes	tail
T8400	41512-41517	SO_EXT:0000704	denotes	genes
T8401	41556-41566	GO_EXT:regulator	denotes	regulators
T8402	41589-41596	UBERON:0000479	denotes	tissues
T8403	41601-41624	UBERON:0000468	denotes	multicellular organisms
T8404	41606-41614	CL_GO_EXT:cell	denotes	cellular
T8405	41615-41624	NCBITaxon:1	denotes	organisms
T8406	41661-41666	PR_EXT:000016145	denotes	Tbx15
T8407	41698-41703	PR_EXT:000016146	denotes	Tbx18
T8408	41708-41713	PR_EXT:000016150	denotes	Tbx22
T8409	41753-41761	NCBITaxon:7711	denotes	chordate
T8410	41796-41800	SO_EXT:0000704	denotes	gene
T8411	41804-41813	NCBITaxon:7740	denotes	amphioxus
T8412	41829-41836	SO_EXT:0000853	denotes	homolog
T8413	41844-41847	NCBITaxon:7147	denotes	fly
T8414	41848-41854	SO_EXT:0001026	denotes	genome
T8415	41924-41929	SO_EXT:0000704	denotes	genes
T8416	41934-41943	GO:0010467	denotes	expressed
T8417	42000-42007	UBERON:0002329	denotes	somites
T8418	42009-42014	PR_EXT:000016146	denotes	Tbx18
T8419	42019-42024	PR_EXT:000016150	denotes	Tbx22
T8420	42027-42042	UBERON:0009749	denotes	limb mesenchyme
T8421	42044-42049	PR_EXT:000016145	denotes	Tbx15
T8422	42054-42059	PR_EXT:000016146	denotes	Tbx18
T8423	42066-42078	UBERON_EXT:face_or_skull	denotes	craniofacial
T8424	42079-42089	UBERON:0003104	denotes	mesenchyme
T8425	42101-42106	SO_EXT:0000704	denotes	genes
T8426	42108-42113	PR_EXT:000016145	denotes	Tbx15
T8427	42132-42137	PR_EXT:000016146	denotes	Tbx18
T8428	42141-42146	PR_EXT:000016150	denotes	Tbx22
T8429	42294-42298	SO_EXT:0000704	denotes	gene
T8430	42303-42308	PR_EXT:000016145	denotes	Tbx15
T8431	42310-42315	PR_EXT:000016146	denotes	Tbx18
T8432	42321-42326	PR_EXT:000016150	denotes	Tbx22
T8433	42355-42367	UBERON_EXT:face_or_skull	denotes	craniofacial
T8434	42383-42399	NCBITaxon:7735	denotes	cephalochordates
T8435	42432-42442	GO:0010467	denotes	expression
T8436	42487-42491	UBERON:0002101	denotes	limb
T8437	42500-42505	UBERON:0002100	denotes	trunk
T8438	42519-42529	NCBITaxon:7742	denotes	vertebrate
T8439	42541-42551	GO:0010467	denotes	Expression
T8440	42555-42560	PR_EXT:000016146	denotes	Tbx18
T8441	42565-42570	PR_EXT:000016150	denotes	Tbx22
T8442	42596-42605	UBERON:0000922	denotes	embryonic
T8443	42606-42611	UBERON:0000180	denotes	flank
T8444	42612-42622	UBERON:0003104	denotes	mesenchyme
T8445	42644-42649	PR_EXT:000016145	denotes	Tbx15
T8446	42734-42739	UBERON:0002100	denotes	trunk
T8447	42825-42832	NCBITaxon:33208	denotes	animals
T8448	42833-42840	SO_EXT:sequence_alteration_process	denotes	mutated
T8449	42892-42896	UBERON_EXT:body	denotes	body
T8450	42923-42928	UBERON:0002101	denotes	limbs
T8451	42937-42941	UBERON:0000033	denotes	head
T8452	42956-42965	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T8453	42969-42974	PR_EXT:000016150	denotes	Tbx22
T8454	42985-42990	NCBITaxon:9606	denotes	human
T8455	43000-43001	GO:0000805	denotes	X
T8456	43088-43093	PR_EXT:000016150	denotes	Tbx22
T8457	43094-43104	GO:0010467	denotes	expression
T8458	43108-43118	_FRAGMENT	denotes	periocular
T8459	43129-43139	UBERON:0004017	denotes	mesenchyme
T8460	43119-43128	UBERON:0000922	denotes	embryonic
T8461	43235-43238	UBERON:0000970	denotes	eye
T8462	43289-43294	PR_EXT:000016145	denotes	Tbx15
T8463	43348-43358	GO:0010467	denotes	expression
T8464	43379-43384	NCBITaxon:10088	denotes	mouse
T8465	43385-43390	PR_EXT:000016145	denotes	Tbx15
T8466	43424-43429	NCBITaxon:9606	denotes	human
T8467	43430-43435	PR_EXT:000016145	denotes	Tbx15
T8468	43449-43459	GO_SO_EXT:chromosome	denotes	Chromosome
T8469	43499-43505	UBERON:0001456	denotes	facial
T8470	43581-43591	GO_SO_EXT:chromosome	denotes	Chromosome
T8471	43648-43657	GO:0030849	denotes	autosomal
T8472	43693-43699	UBERON:0001456	denotes	facial
T8473	43716-43722	GO_EXT:biological_growth_entity_or_process	denotes	growth
T8474	43735-43739	UBERON:0000165	denotes	oral
T8475	43740-43746	UBERON:0000344	denotes	mucosa
T8476	43766-43771	UBERON:0002398	denotes	hands
T8477	44102-44111	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T8478	44115-44120	NCBITaxon:9606	denotes	human
T8479	44121-44126	PR_EXT:000016145	denotes	TBX15
T8480	44175-44184	GO:0030849	denotes	autosomal
T8481	44259-44266	UBERON:0004089	denotes	midface
T8482	44369-44377	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T8483	44404-44412	UBERON:0004288	denotes	skeletal
T8484	44404-44424	GO:0001501	denotes	skeletal development
T8485	44486-44490	SO_EXT:0000704	denotes	gene
T8486	44491-44495	PR_EXT:000003979	denotes	Alx3
T8487	44505-44512	SO_EXT:0001023	denotes	allelic
T8488	44525-44528	UBERON:0001690	denotes	ear
T8489	44587-44595	UBERON:0004288	denotes	skeletal
T8490	44618-44622	PR_EXT:000003979	denotes	Alx3
T8491	44626-44630	PR_EXT:000003980	denotes	Alx4
T8492	44631-44638	SO_EXT:sequence_altered_entity	denotes	mutants
T8493	44703-44707	PR_EXT:000003979	denotes	Alx3
T8494	44747-44752	PR_EXT:000016145	denotes	Tbx15
T8495	44753-44761	UBERON:0004288	denotes	skeletal
T9275	44835-44845	GO:0010467	denotes	Expression
T9276	44864-44868	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	Skin
T9277	44898-44903	PR_EXT:000016145	denotes	Tbx15
T9278	44907-44914	CHEBI_EXT:26130	denotes	pigment
T9279	44915-44925	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterning
T9280	44958-44964	PR_EXT:000004372	denotes	Agouti
T9281	44972-44977	GO:0007567	denotes	natal
T9282	44978-44985	NCBITaxon:33208	denotes	animals
T9283	44996-45002	PR_EXT:000004372	denotes	Agouti
T9284	45011-45020	GO:0010467	denotes	expressed
T9285	45028-45034	UBERON:0000922	denotes	embryo
T9286	45067-45073	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T9287	45085-45091	UBERON:0002067	denotes	dermis
T9288	45132-45141	UBERON:0000922	denotes	embryonic
T9289	45142-45148	PR_EXT:000004372	denotes	Agouti
T9290	45149-45159	GO:0010467	denotes	expression
T9291	45171-45178	NCBITaxon:33208	denotes	animals
T9292	45218-45223	PR_EXT:000016145	denotes	Tbx15
T9293	45240-45250	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterning
T9294	45300-45305	SO_EXT:0000704	denotes	genes
T9295	45467-45481	GO_PATO_RO_EXT:developmental_differentiation_process_or_quality	denotes	differentiated
T9296	45482-45490	_FRAGMENT	denotes	group of
T9297	45501-45506	UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population	denotes	cells
T9298	45501-45506	CL_GO_EXT:cell	denotes	cells
T9299	45553-45579	_FRAGMENT	denotes	proliferative expansion of
T9300	45582-45597	GO:0008283	denotes	cell population
T9301	45582-45586	CL_GO_EXT:cell	denotes	cell
T9302	45582-45597	UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population	denotes	cell population
T9303	45753-45757	NCBITaxon:10088	denotes	mice
T9304	45801-45807	PR_EXT:000004372	denotes	Agouti
T9305	45808-45818	GO:0010467	denotes	expression
T9306	45826-45831	GO:0007567	denotes	natal
T9307	45840-45847	NCBITaxon:33208	denotes	animals
T9308	45941-45950	UBERON:0000922	denotes	embryonic
T9309	45941-45956	CL:0002321	denotes	embryonic cells
T9310	45951-45956	CL_GO_EXT:cell	denotes	cells
T9311	45973-45983	UBERON:0003104	denotes	mesenchyme
T9312	46044-46049	CL_GO_EXT:cell	denotes	cells
T9313	46058-46069	GO:0008283	denotes	proliferate
T9314	46126-46131	CL_GO_EXT:cell	denotes	cells
T9315	46133-46137	CL_GO_EXT:cell	denotes	Cell
T9316	46284-46288	UBERON:0001037	denotes	hair
T9317	46306-46310	NCBITaxon:10088	denotes	mice
T9318	46427-46432	UBERON:0000180	denotes	flank
T9319	46459-46468	UBERON:0000922	denotes	embryonic
T9320	46469-46479	UBERON:0003104	denotes	mesenchyme
T9321	46481-46491	GO:0010467	denotes	expression
T9322	46495-46500	PR_EXT:000016145	denotes	Tbx15
T9323	46505-46511	PR_EXT:000004372	denotes	Agouti
T9324	46555-46560	PR_EXT:000016145	denotes	Tbx15
T9325	46586-46592	PR_EXT:000004372	denotes	Agouti
T9326	46593-46606	GO_EXT:transcription	denotes	transcription
T9327	46623-46633	UBERON:0003104	denotes	mesenchyme
T9328	46659-46664	PR_EXT:000016145	denotes	Tbx15
T9329	46677-46687	GO:0010467	denotes	expression
T9330	46712-46718	PR_EXT:000004372	denotes	Agouti
T9331	46719-46726	SO_EXT:0001060	denotes	isoform
T9332	46734-46739	GO:0007567	denotes	natal
T9333	46740-46744	NCBITaxon:10088	denotes	mice
T9334	46781-46786	GO:0007567	denotes	natal
T9335	46787-46797	GO:0010467	denotes	expression
T9336	46801-46806	PR_EXT:000016145	denotes	Tbx15
T9337	46888-46894	PR_EXT:000004372	denotes	Agouti
T9338	46927-46932	PR_EXT:000016145	denotes	Tbx15
T9339	46947-46951	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T9340	46960-46965	SO_EXT:0000704	denotes	genes
T9341	46981-46987	PR_EXT:000004372	denotes	Agouti
T9342	46995-46999	UBERON:0001037	denotes	hair
T9343	46995-46999	_FRAGMENT	denotes	hair
T9344	47011-47021	CL:0002483	denotes	melanocyte
T9345	47088-47095	NCBITaxon:33208	denotes	animals
T9346	47109-47113	SO_EXT:sequence_nullness	denotes	null
T9347	47114-47120	PR_EXT:000004372	denotes	Agouti
T9348	47121-47127	SO_EXT:0001023	denotes	allele
T9349	47153-47157	PR_EXT:000003980	denotes	Alx4
T9350	47171-47177	PR_EXT:000004372	denotes	Agouti
T9351	47182-47191	GO:0010467	denotes	expressed
T9352	47203-47212	UBERON:0000922	denotes	embryonic
T9353	47213-47223	UBERON:0003104	denotes	mesenchyme
T9354	47235-47242	SO_EXT:sequence_alteration_process	denotes	mutated
T9355	47252-47265	UBERON:0002073	denotes	hair-follicle
T9356	47277-47281	UBERON:0002101	denotes	limb
T9357	47277-47281	_FRAGMENT	denotes	limb
T9358	47299-47310	GO:0060173	denotes	development
T9359	47286-47298	UBERON_EXT:face_or_skull	denotes	craniofacial
T9360	47405-47415	GO:0010467	denotes	expression
T9361	47427-47434	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T9362	47443-47447	PR_EXT:000003980	denotes	Alx4
T9363	47460-47464	PR_EXT:000003979	denotes	Alx3
T9364	47469-47473	PR_EXT:000010687	denotes	Msx2
T9365	47520-47527	UBERON:0000922	denotes	embryos
T10075	47592-47596	UBERON:0002101	denotes	Limb
T10076	47597-47607	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	Patterning
T10077	47616-47621	PR_EXT:000016145	denotes	Tbx15
T10078	47660-47664	UBERON:0001037	denotes	hair
T10079	47678-47683	UBERON:0002101	denotes	limbs
T10080	47730-47734	UBERON:0001037	denotes	hair
T10081	47757-47761	UBERON:0001037	denotes	hair
T10082	47807-47814	CHEBI_EXT:26130	denotes	pigment
T10083	47837-47841	UBERON:0002101	denotes	limb
T10084	47874-47878	NCBITaxon:10088	denotes	mice
T10085	47965-47968	PR_EXT:000007070	denotes	En1
T10086	47972-47977	PR_EXT:000017448	denotes	Wnt7a
T10087	48030-48034	UBERON:0002101	denotes	limb
T10088	48040-48046	UBERON:0001137	denotes	dorsum
T10089	48050-48057	UBERON:0013235	denotes	ventrum
T10090	48082-48089	UBERON:0013235	denotes	ventrum
T10091	48093-48099	UBERON:0001137	denotes	dorsum
T10092	48178-48184	PR_EXT:000004372	denotes	Agouti
T10093	48185-48195	GO:0010467	denotes	expression
T10094	48215-48219	UBERON:0001037	denotes	hair
T10095	48272-48284	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T10096	48300-48308	UBERON:0013623	denotes	footpads
T10097	48326-48329	PR_EXT:000007070	denotes	En1
T10098	48330-48336	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T10099	48337-48341	NCBITaxon:10088	denotes	mice
T10100	48358-48365	CHEBI_EXT:26130	denotes	pigment
T10101	48427-48430	PR_EXT:000007070	denotes	En1
T10102	48447-48452	PR_EXT:000017448	denotes	Wnt7a
T10103	48465-48474	_FRAGMENT	denotes	migration
T10104	48502-48504	_FRAGMENT	denotes	of
T10105	48513-48518	GO:0016477	denotes	cells
T10106	48478-48491	_FRAGMENT	denotes	proliferation
T10107	48513-48518	GO:0008283	denotes	cells
T10108	48505-48512	CHEBI_EXT:26130	denotes	pigment
T10109	48505-48518	CL:0000147	denotes	pigment cells
T10110	48513-48518	CL_GO_EXT:cell	denotes	cells
T10111	48530-48539	UBERON:0007376	denotes	epidermis
T10112	48620-48627	GO:0065007	denotes	control
T10113	48644-48649	UBERON:0002100	denotes	trunk
T10114	48661-48666	PR_EXT:000016145	denotes	Tbx15
T10115	48696-48703	GO:0065007	denotes	control
T10116	48720-48724	UBERON:0002101	denotes	limb
T10117	48725-48735	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterning
T10118	48739-48744	PR_EXT:000009871	denotes	Lmx1b
T10119	48752-48758	SO_EXT:0000417	denotes	domain
T10120	48759-48772	GO_EXT:transcription	denotes	transcription
T10121	48759-48779	GO_EXT:transcription_factor	denotes	transcription factor
T10122	48804-48809	PR_EXT:000017448	denotes	Wnt7a
T10123	48814-48817	PR_EXT:000007070	denotes	En1
T10124	48945-48950	PR_EXT:000016145	denotes	Tbx15
T10125	48955-48960	PR_EXT:000009871	denotes	Lmx1b
T10126	48981-48992	UBERON:0003104	denotes	mesenchymal
T10127	48981-48998	CL:0000134	denotes	mesenchymal cells
T10128	48993-48998	CL_GO_EXT:cell	denotes	cells
T10129	49038-49048	GO:0010467	denotes	expression
T10130	49083-49087	CL_GO_EXT:cell	denotes	cell
T10131	49116-49121	UBERON:0000180	denotes	flank
T10132	49123-49128	PR_EXT:000016145	denotes	Tbx15
T10133	49137-49141	UBERON:0002101	denotes	limb
T10134	49143-49148	PR_EXT:000009871	denotes	Lmx1b
T10135	49209-49214	PR_EXT:000009871	denotes	Lmx1b
T10136	49220-49230	GO:0010467	denotes	expression
T10137	49245-49249	UBERON:0002101	denotes	limb
T10138	49261-49266	PR_EXT:000017448	denotes	Wnt7a
T10139	49300-49308	UBERON:0000924	denotes	ectoderm
T10140	49370-49375	PR_EXT:000017448	denotes	Wnt7a
T10141	49410-49418	UBERON:0000924	denotes	ectoderm
T10142	49422-49425	PR_EXT:000007070	denotes	En1
T10143	49441-49449	UBERON:0000924	denotes	ectoderm
T10144	49516-49526	GO:0010467	denotes	expression
T10145	49527-49532	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	marks
T10146	49600-49623	UBERON:0004356	denotes	apical ectodermal ridge
T10147	49708-49711	PR_EXT:000007070	denotes	En1
T10148	49715-49720	PR_EXT:000017448	denotes	Wnt7a
T10149	49721-49730	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T10150	49776-49780	UBERON:0001037	denotes	hair
T10151	49914-49924	UBERON:0000924	denotes	ectodermal
T10152	49946-49953	GO:0065007	denotes	control
T10153	49977-49987	UBERON:0003104	denotes	mesenchyme
T10154	50002-50007	UBERON:0002101	denotes	limbs
T10155	50025-50030	UBERON:0002100	denotes	trunk
T10156	50046-50050	UBERON:0002101	denotes	limb
T10157	50056-50070	UBERON:0001911	denotes	mammary glands
T10158	50137-50147	UBERON:0000483	denotes	epithelial
T10159	50148-50159	UBERON:0003104	denotes	mesenchymal
T10160	50223-50237	UBERON:0001911	denotes	mammary glands
T10161	50260-50267	NCBITaxon:33208	denotes	animals
T10162	50324-50331	GO:0065007	denotes	control
T10163	50345-50355	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterning
T10164	50363-50368	UBERON:0002100	denotes	trunk
T10165	50387-50392	UBERON:0002101	denotes	limbs
T10166	50497-50509	UBERON:0011270	denotes	dorsal trunk
T10167	50510-50518	UBERON:0000924	denotes	ectoderm
T10168	50551-50561	GO:0010467	denotes	expression
T10169	50565-50570	PR_EXT:000016145	denotes	Tbx15
T10170	50574-50586	UBERON:0011270	denotes	dorsal trunk
T10171	50587-50597	UBERON:0003104	denotes	mesenchyme
T10172	50658-50663	CL_GO_EXT:cell	denotes	cells
T10173	50696-50702	PR_EXT:000004372	denotes	Agouti
T10174	50703-50713	GO:0010467	denotes	expression
T10175	50715-50722	CHEBI_EXT:26130	denotes	pigment
T10176	50715-50727	CL:0000147	denotes	pigment-cell
T10177	50715-50739	GO:0070285	denotes	pigment-cell development
T10178	50723-50727	CL_GO_EXT:cell	denotes	cell
T10179	50745-50749	UBERON:0001037	denotes	hair
T10180	50750-50756	GO_EXT:biological_growth_entity_or_process	denotes	growth
T10181	50787-50792	PR_EXT:000016145	denotes	Tbx15
T10182	50793-50803	GO:0010467	denotes	expression
T10183	50839-50842	PR_EXT:000007070	denotes	En1
T10184	50843-50853	GO:0010467	denotes	expression
T10185	50893-50905	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T10186	50955-50963	UBERON:0004347	denotes	limb-bud
T10187	51038-51043	UBERON:0002100	denotes	trunk
T10188	51044-51052	UBERON:0000924	denotes	ectoderm
T10189	51076-51080	UBERON:0002101	denotes	limb
T10190	51149-51154	NCBITaxon_UBERON_EXT:chick	denotes	chick
T10191	51221-51229	UBERON:0000924	denotes	ectoderm
T10192	51242-51246	UBERON:0002101	denotes	limb
T10193	51325-51329	UBERON:0002101	denotes	limb
T10194	51379-51383	UBERON:0002101	denotes	limb
T10195	51384-51392	UBERON:0000926	denotes	mesoderm
T10196	51510-51515	UBERON:0002101	denotes	limbs
T10197	51524-51547	UBERON:0004356	denotes	apical ectodermal ridge
T10198	51564-51574	GO:0010467	denotes	expression
T10199	51578-51583	PR_EXT:000016145	denotes	Tbx15
T10200	51591-51596	UBERON:0002100	denotes	trunk
T10201	51612-51617	UBERON:0002101	denotes	limbs
T10202	51638-51642	UBERON:0002101	denotes	limb
T10203	51737-51746	UBERON:0004347	denotes	limb buds
T10204	51763-51775	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T10205	51906-51916	GO:0010467	denotes	expression
T10206	51920-51925	PR_EXT:000016145	denotes	Tbx15
T10207	51929-51947	UBERON:2000164	denotes	ventral mesenchyme
T10208	51981-51993	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T10209	52067-52072	PR_EXT:000016145	denotes	Tbx15
T10210	52073-52083	GO:0010467	denotes	expression
T10211	52128-52136	UBERON:0000926	denotes	mesoderm
T10212	52183-52188	PR_EXT:000016145	denotes	Tbx15
T10213	52200-52204	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T10214	52205-52215	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterning
T10215	52271-52303	GO:0048263	denotes	establishment of dorsal identity
T10216	52307-52312	PR_EXT:000016145	denotes	Tbx15
T10217	52388-52398	UBERON:0003104	denotes	mesenchyme
T10218	52417-52425	UBERON:0000924	denotes	ectoderm
T11236	52428-52440	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	Pigmentation
T11237	52454-52459	PR_EXT:000016145	denotes	Tbx15
T11238	52469-52476	NCBITaxon:40674	denotes	Mammals
T11239	52489-52505	UBERON:0015178	denotes	somitic frontier
T11240	52547-52553	UBERON:0002329	denotes	somite
T11241	52569-52582	UBERON:0003081	denotes	lateral plate
T11242	52591-52599	UBERON:0000926	denotes	mesoderm
T11243	52623-52636	GO_EXT:somite_development_or_somitogenesis	denotes	somitogenesis
T11244	52772-52777	GO:0007567	denotes	natal
T11245	52778-52785	NCBITaxon:33208	denotes	animals
T11246	52822-52826	CL_GO_EXT:cell	denotes	cell
T11247	52933-52949	UBERON:0015178	denotes	somitic frontier
T11248	52969-52981	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T11249	53045-53049	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T11250	53156-53160	PR_EXT:000010686	denotes	Msx1
T11251	53168-53178	GO:0010467	denotes	expression
T11252	53179-53184	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	marks
T11253	53199-53205	UBERON:0002329	denotes	somite
T11254	53214-53225	UBERON:0003104	denotes	mesenchymal
T11255	53214-53231	CL:0000134	denotes	mesenchymal cells
T11256	53226-53231	CL_GO_EXT:cell	denotes	cells
T11257	53251-53257	UBERON:0002067	denotes	dermis
T11258	53270-53276	UBERON:2001463	denotes	stripe
T11259	53392-53397	GO:0007567	denotes	natal
T11260	53398-53407	NCBITaxon:40674	denotes	mammalian
T11261	53408-53412	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T11262	53479-53486	CHEBI_EXT:26130	denotes	pigment
T11263	53518-53522	CL_GO_EXT:cell	denotes	cell
T11264	53551-53561	GO:0010467	denotes	expression
T11265	53565-53569	PR_EXT:000010686	denotes	Msx1
T11266	53574-53581	NCBITaxon:9989	denotes	rodents
T11267	53592-53604	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T11268	53646-53653	NCBITaxon:40674	denotes	mammals
T11269	53688-53692	UBERON:0001037	denotes	hair
T11270	53759-53767	NCBITaxon:9654	denotes	Raccoons
T11271	53769-53778	NCBITaxon:55153	denotes	squirrels
T11272	53780-53786	NCBITaxon:119825	denotes	skunks
T11273	53807-53816	NCBITaxon_EXT:ungulate	denotes	ungulates
T11274	53833-53840	UBERON:2001463	denotes	stripes
T11275	53931-53947	UBERON:0015178	denotes	somitic frontier
T11276	53964-53968	PR_EXT:000010686	denotes	Msx1
T11277	54037-54042	PR_EXT:000016145	denotes	Tbx15
T11278	54046-54058	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T11279	54073-54077	NCBITaxon:10088	denotes	mice
T11280	54096-54100	UBERON:0010166	denotes	coat
T11281	54166-54173	NCBITaxon:40674	denotes	mammals
T11282	54182-54190	UBERON:2002284	denotes	markings
T11283	54210-54213	NCBITaxon:9615	denotes	dog
T11284	54278-54299	NCBITaxon:42413	denotes	Peromyscus polionotus
T11285	54342-54354	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T11286	54389-54399	NCBITaxon:subspecies	denotes	subspecies
T11287	54508-54517	NCBITaxon:10040	denotes	deer mice
T11288	54523-54535	UBERON_EXT:face_or_skull	denotes	craniofacial
T11289	54571-54579	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T11290	54589-54601	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T11291	54620-54627	NCBITaxon:33208	denotes	animals
T11292	54663-54673	GO:0065007	denotes	regulation
T11293	54687-54692	PR_EXT:000016145	denotes	Tbx15
T11294	54749-54754	PR_EXT:000016145	denotes	Tbx15
T11295	54758-54762	UBERON:0010166	denotes	coat
T11296	54798-54805	SO_EXT:0000704	denotes	genetic
T11297	54851-54858	NCBITaxon:40674	denotes	mammals
T11298	54882-54894	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T11299	54918-54926	SO_EXT:biological_sequence	denotes	sequence
T11300	54931-54941	GO:0010467	denotes	expression
T11301	54945-54950	PR_EXT:000016145	denotes	Tbx15
T11302	54960-54971	NCBITaxon:7742	denotes	vertebrates
T11303	55033-55041	UBERON:0004288	denotes	skeleton
T11304	55057-55067	CHEBI_EXT:26130	denotes	pigmentary
T11784	55109-55113	NCBITaxon:10088	denotes	mice
T11785	55300-55305	PR_EXT:000008703	denotes	Hoxb6
T11786	55310-55320	SO_EXT:transgenic_entity	denotes	transgenic
T11787	55321-55325	NCBITaxon:10088	denotes	mice
T11788	55429-55433	NCBITaxon:10088	denotes	mice
T11789	55452-55456	PR_EXT:000033987	denotes	lacZ
T11790	55466-55472	SO_EXT:0001023	denotes	allele
T11791	55606-55610	NCBITaxon:10088	denotes	mice
T11792	55723-55731	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T11793	55898-55904	SO_EXT:0001023	denotes	allele
T11794	55971-55972	SO_EXT:normal_or_wild_type_or_present	denotes	+
T11795	55979-55980	SO_EXT:normal_or_wild_type_or_present	denotes	+
T11796	56049-56056	GO:0007618	denotes	matings
T11797	56077-56081	UBERON:0010148	denotes	plug
T11798	56107-56114	GO:0007567	denotes	natally
T11799	56127-56132	GO:0007567	denotes	birth
T12062	56201-56205	UBERON:0001037	denotes	hair
T12063	56240-56244	UBERON:0002101	denotes	limb
T12064	56245-56259	UBERON:0000014	denotes	region of skin
T12065	56353-56371	CHEBI:32139	denotes	sodium bicarbonate
T12066	56452-56456	UBERON:0001037	denotes	hair
T12067	56663-56667	UBERON:0010511	denotes	awls
T12068	56672-56680	UBERON:0010510	denotes	auchenes
T12069	56726-56734	GO:0007601	denotes	visually
T12070	56757-56763	_FRAGMENT	denotes	zigzag
T12071	56769-56774	UBERON:0010513	denotes	hairs
T12072	56812-56816	UBERON:0001037	denotes	hair
T12073	56852-56857	UBERON:0001037	denotes	hairs
T12074	56883-56889	UBERON:0001137	denotes	dorsum
T12075	56896-56903	UBERON:0013235	denotes	ventrum
T12076	56916-56920	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T12077	56931-56938	NCBITaxon:33208	denotes	animals
T12078	57042-57046	UBERON:0010511	denotes	awls
T12079	57051-57059	UBERON:0010510	denotes	auchenes
T12080	57065-57069	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T12081	57144-57155	CHEBI:51686	denotes	hematoxylin
T12082	57160-57165	CHEBI_EXT:eosin	denotes	eosin
T12083	57171-57175	CHEBI:49168	denotes	DOPA
T12084	57190-57196	UBERON:0002067	denotes	dermis
T12085	57201-57210	UBERON:0007376	denotes	epidermis
T12086	57253-57267	CHEBI:63004	denotes	sodium bromide
T12087	57306-57320	UBERON:0002073	denotes	hair follicles
T12088	57340-57346	UBERON:0002067	denotes	dermis
T12089	57411-57417	CHEBI:15765	denotes	L-DOPA
T12090	57469-57485	CHEBI:37586	denotes	sodium phosphate
T12091	57486-57492	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T12092	57553-57561	CHEBI:75958	denotes	solution
T12093	57677-57687	UBERON_EXT:follicle	denotes	follicular
T12094	57688-57699	CL:0000148	denotes	melanocytes
T12095	57740-57748	CHEBI_EXT:50913	denotes	fixative
T12096	57768-57784	CHEBI_EXT:paraformaldehye	denotes	paraformaldehyde
T12472	57798-57805	SO_EXT:sequence_cloning_process	denotes	cloning
T12473	57914-57918	NCBITaxon:10088	denotes	mice
T12474	57999-58006	NCBITaxon:33208	denotes	animals
T12475	58016-58027	GO_SO_EXT:sequence_rearrangement_process	denotes	recombinant
T12476	58028-58039	GO_SO_EXT:chromosome	denotes	chromosomes
T12477	58054-58061	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T12478	58068-58076	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T12479	58106-58107	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12480	58111-58112	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12481	58113-58114	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12482	58159-58166	NCBITaxon:33208	denotes	animals
T12483	58176-58183	SO_EXT:0000704	denotes	genetic
T12484	58274-58281	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T12485	58322-58334	SO_EXT:0001249	denotes	physical map
T12486	58340-58343	SO_EXT:0000153	denotes	BAC
T12487	58344-58358	SO_EXT:0000040	denotes	genomic clones
T12488	58369-58377	OBI_SO_EXT:gene_or_genetic_investigation_or_genetic_process	denotes	Genetics
T12489	58419-58425	SO_EXT:0001026	denotes	Genome
T12490	58476-58484	SO_EXT:biological_sequence	denotes	sequence
T12491	58496-58500	SO_EXT:0000153	denotes	BACs
T12492	58526-58533	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T12493	58622-58623	CHEBI_SO_EXT:base	denotes	b
T12494	58625-58631	SO_EXT:0000112	denotes	Primer
T12495	58915-58921	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T12496	58933-58936	SO_EXT:0000331	denotes	STS
T12497	58954-58961	SO_EXT:0001026	denotes	Genomic
T12498	58962-58970	SO_EXT:biological_sequence	denotes	sequence
T12499	59015-59021	SO_EXT:0001026	denotes	Genome
T12500	59044-59052	SO_EXT:sequence_assembly_entity_or_process	denotes	assembly
T12501	59073-59079	SO_EXT:0001026	denotes	genome
T12502	59100-59101	CHEBI_SO_EXT:base	denotes	b
T12503	59144-59149	SO_EXT:0000704	denotes	genes
T12504	59156-59170	CHEBI:35350	denotes	hydroxysteroid
T12505	59185-59195	GO_EXT:0016853	denotes	isomerases
T12506	59197-59203	PR_EXT:000008867	denotes	Hsd3b3
T12507	59205-59211	PR_EXT:000008786	denotes	Hsd3b2
T12508	59213-59219	PR_EXT:000008870	denotes	Hsd3b6
T12509	59225-59231	PR_EXT:000008785	denotes	Hsd3b1
T12510	59236-59245	CHEBI:24669	denotes	hydroacid
T12511	59255-59259	PR_EXT:000008442	denotes	Hao3
T12512	59263-59280	CHEBI_SO_EXT:tRNA_Trp	denotes	tryptophanyl-tRNA
T12513	59263-59291	GO_EXT:0004830	denotes	tryptophanyl-tRNA synthetase
T12514	59293-59298	PR_EXT:000017370	denotes	Wars2
T12515	59308-59312	SO_EXT:0000704	denotes	gene
T12516	59314-59319	PR_EXT:000016145	denotes	Tbx15
T12517	59333-59337	SO_EXT:0000704	denotes	gene
T12518	59339-59352	PR_EXT:000015456	denotes	4931427F14Rik
T12519	59361-59367	SO_EXT:0001026	denotes	genome
T12520	59368-59376	SO_EXT:biological_sequence	denotes	sequence
T12521	59381-59388	SO_EXT:0000112	denotes	primers
T12522	59470-59484	SO_EXT:0000132	denotes	reverse primer
T12523	59538-59545	SO_EXT:0000112	denotes	primers
T12524	59649-59658	SO_EXT:biological_sequence	denotes	sequences
T12525	59666-59673	SO_EXT:0000112	denotes	primers
T12526	59695-59703	SO_EXT:0000999	denotes	BAC ends
T12527	59719-59725	SO_EXT:0001026	denotes	genome
T12528	59726-59734	SO_EXT:biological_sequence	denotes	sequence
T12529	59796-59799	SO_EXT:0000153	denotes	BAC
T12530	59800-59803	CHEBI_SO_EXT:DNA	denotes	DNA
T12531	59872-59880	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T12532	59887-59894	SO_EXT:0000112	denotes	primers
T12533	59995-59997	SO_EXT:0000028	denotes	bp
T12534	60019-60029	GO_SO_EXT:chromosome	denotes	chromosome
T12535	60040-60042	SO_EXT:0000028	denotes	bp
T12536	60063-60069	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T12537	60070-60080	GO_SO_EXT:chromosome	denotes	chromosome
T12969	60453-60459	SO_EXT:sequence_cloned_entity	denotes	clones
T12970	60482-60493	UBERON:0000358	denotes	blastocysts
T12971	60538-60542	NCBITaxon:10088	denotes	mice
T12972	60553-60554	SO_EXT:normal_or_wild_type_or_present	denotes	+
T12973	60555-60562	NCBITaxon:33208	denotes	animals
T13102	60573-60586	GO:0097617	denotes	hybridization
T13103	60595-60608	GO:0097617	denotes	hybridization
T13104	60658-60669	CHEBI:42098	denotes	digoxigenin
T13105	60670-60677	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labeled
T13106	60678-60688	CHEBI_SO_EXT:riboprobe	denotes	RNA probes
T13107	60807-60814	UBERON:0000922	denotes	Embryos
T13108	60823-60828	GO:0007567	denotes	natal
T13109	60829-60833	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T13110	60881-60882	SO_EXT:normal_or_wild_type_or_present	denotes	+
T13111	60883-60887	NCBITaxon:10088	denotes	mice
T13112	60889-60896	UBERON:0000922	denotes	Embryos
T13113	60966-60971	GO:0007567	denotes	natal
T13114	60972-60976	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T13115	61024-61029	PR_EXT:000016145	denotes	Tbx15
T13116	61030-61035	CHEBI_SO_EXT:molecular_probe	denotes	probe
T13117	61053-61055	GO_EXT:reverse_transcription_or_reverse_transcriptase	denotes	RT
T13118	61066-61073	SO_EXT:0000112	denotes	primers
T13119	61135-61140	SO_EXT:0000147	denotes	exons
T13120	61159-61162	PR_EXT:000007070	denotes	En1
T13121	61163-61168	CHEBI_SO_EXT:molecular_probe	denotes	probe
T13122	61195-61206	SO_EXT:genomic_DNA	denotes	genomic DNA
T13123	61203-61206	CHEBI_SO_EXT:DNA	denotes	DNA
T13124	61213-61220	SO_EXT:0000112	denotes	primers
T13125	61288-61292	SO_EXT:0000147	denotes	exon
T13126	61299-61305	PR_EXT:000004372	denotes	Agouti
T13127	61306-61311	CHEBI_SO_EXT:molecular_probe	denotes	probe
T13128	61331-61338	CHEBI_PR_EXT:protein	denotes	protein
T13129	61331-61345	SO:0000010	denotes	protein-coding
T13130	61339-61354	SO_EXT:coding_sequence	denotes	coding sequence
T13302	61357-61366	UBERON:0000922	denotes	Embryonic
T13303	61367-61371	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T13304	61412-61419	UBERON:0000922	denotes	embryos
T13305	61464-61472	CHEBI:75958	denotes	solution
T13306	61478-61487	UBERON:0000922	denotes	embryonic
T13307	61488-61492	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T13308	61518-61523	UBERON:0000180	denotes	flank
T13309	61589-61593	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	Skin
T13310	61624-61630	UBERON:0000473	denotes	testes
T13311	61643-61650	NCBITaxon:33208	denotes	animals
T13312	61669-61684	CHEBI_EXT:anaesthetic_process	denotes	anesthetization
T13313	61729-61733	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T13314	61738-61747	UBERON:0000309	denotes	body wall
T13315	61762-61767	UBERON:0006983	denotes	point
T13316	61794-61799	UBERON:0002101	denotes	limbs
T13317	61805-61808	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T13318	61805-61813	UBERON:0003916	denotes	fat pads
T13319	61861-61865	UBERON_EXT:body	denotes	body
T13320	61880-61886	UBERON:0000473	denotes	testes
T13321	61939-61953	UBERON:0006643	denotes	testis capsule
T13322	61989-61998	UBERON:0000922	denotes	embryonic
T13323	61999-62003	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T13324	62022-62028	UBERON:0000473	denotes	testes
T13325	62057-62073	UBERON:0003684	denotes	abdominal cavity
T13326	62112-62121	UBERON:0000309	denotes	body wall
T13327	62130-62134	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T13328	62151-62155	NCBITaxon:10088	denotes	mice
T13329	62182-62192	GO_EXT:killing	denotes	sacrificed
T13330	62211-62215	UBERON:0001037	denotes	hair
T13331	62239-62245	UBERON:0000473	denotes	testes
T13548	62286-62302	UBERON:0015178	denotes	somitic frontier
T13549	62307-62312	PR_EXT:000008703	denotes	Hoxb6
T13550	62317-62326	SO_EXT:0000902	denotes	transgene
T13551	62383-62392	GO:0010467	denotes	expressed
T13552	62400-62413	_FRAGMENT	denotes	lateral plate
T13553	62434-62442	UBERON:0003081	denotes	mesoderm
T13554	62426-62442	UBERON:0003077	denotes	somitic mesoderm
T13555	62450-62455	UBERON:0002100	denotes	trunk
T13556	62476-62483	NCBITaxon:33208	denotes	Animals
T13557	62513-62522	SO_EXT:0000902	denotes	transgene
T13558	62545-62549	SO_EXT:0000704	denotes	gene
T13559	62581-62585	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T13560	62603-62607	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	Skin
T13561	62698-62713	UBERON:0009571	denotes	ventral midline
T13562	62730-62745	GO_EXT:0004565	denotes	β-galactosidase
T13563	62903-62907	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T13564	62936-62943	NCBITaxon:33208	denotes	animals
T13565	62960-62966	SO_EXT:0001023	denotes	allele
T13566	62992-62996	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T13567	63065-63071	UBERON:0002329	denotes	somite
T13568	63072-63085	UBERON:0003081	denotes	lateral plate
T13569	63094-63106	GO_PATO_EXT:biological_pigmentation_process_or_quality	denotes	pigmentation
T12950	60083-60087	SO_EXT:0000704	denotes	Gene
T12951	60109-60115	SO_EXT:0001023	denotes	allele
T12952	60119-60124	PR_EXT:000016145	denotes	Tbx15
T12953	60211-60215	SO_EXT:0000243	denotes	IRES
T12954	60216-60220	PR_EXT:000033987	denotes	LacZ
T12955	60221-60224	CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase	denotes	neo
T12956	60225-60233	SO_EXT:0005853	denotes	cassette
T12957	60271-60272	CHEBI_SO_EXT:base	denotes	b
T12958	60282-60283	CHEBI_SO_EXT:base	denotes	b
T12959	60288-60296	SO_EXT:sequence_insertion_process	denotes	inserted
T12960	60311-60316	PR_EXT:P23940	denotes	BamHI
T12961	60336-60347	CHEBI_SO_EXT:nucleotide	denotes	nucleotides
T12962	60348-60358	SO_EXT:sequence_downstreamness	denotes	downstream
T12963	60366-60381	GO_EXT:transcription	denotes	transcriptional
T12964	60366-60397	SO_EXT:0000315	denotes	transcriptional initiation site
T12965	60415-60419	CHEBI_SO_EXT:mRNA	denotes	mRNA
T12966	60420-60428	SO_EXT:biological_sequence	denotes	sequence
T12967	60433-60437	SO_EXT:0000147	denotes	exon
T12968	60450-60452	CL:0002322	denotes	ES
T124	753-757	SO_EXT:0000147	denotes	exon
T9274	44829-44834	PR_EXT:000016145	denotes	Tbx15
T5443	27866-27876	GO:0010467	denotes	expression
T949	7781-7786	UBERON:0007023	denotes	adult
T950	7787-7791	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T951	7886-7890	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T952	8024-8029	NCBITaxon:10088	denotes	mouse
T953	8091-8097	PR_EXT:000004372	denotes	Agouti
T954	8098-8108	GO:0010467	denotes	expression
T955	8153-8159	UBERON:0002329	denotes	somite
T956	8165-8178	UBERON:0003081	denotes	lateral plate
T957	8328-8338	CL:0000148	denotes	melanocyte
T958	8354-8369	GO_RO_EXT:developmental_differentiation_process	denotes	differentiation
T959	8371-8378	CHEBI_EXT:26130	denotes	pigment
T960	8399-8403	UBERON:0001037	denotes	hair
T961	8458-8464	UBERON:0002329	denotes	somite
T962	8465-8478	UBERON:0003081	denotes	lateral plate
T963	8529-8534	NCBITaxon:10088	denotes	mouse
T964	8535-8543	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T965	8552-8555	UBERON:0001690	denotes	ear
T966	8622-8627	UBERON:0000180	denotes	flank
T967	8628-8632	UBERON:0010166	denotes	coat
T968	8685-8691	PR_EXT:000004372	denotes	Agouti
T969	8692-8702	SO_EXT:0000673	denotes	transcript
T970	8718-8725	SO_EXT:sequence_cloning_process	denotes	cloning
T971	8730-8734	SO_EXT:0000704	denotes	gene
T972	8761-8767	SO_EXT:0001023	denotes	allele
T973	8778-8781	UBERON:0001690	denotes	ear
T974	8814-8819	PR_EXT:000016145	denotes	Tbx15
T975	8827-8834	SO_EXT:sequence_coding_function	denotes	encodes
T976	8843-8856	GO_EXT:transcription	denotes	transcription
T977	8843-8863	GO_EXT:transcription_factor	denotes	transcription factor
T978	8864-8873	GO:0010467	denotes	expressed
T979	8937-8941	UBERON_EXT:zone_of_skin_or_skin_of_body	denotes	skin
T980	8946-8968	UBERON:0002204	denotes	musculoskeletal system
T981	8970-8979	UBERON:0000922	denotes	Embryonic
T982	8980-8990	GO:0010467	denotes	expression
T983	9032-9037	PR_EXT:000016145	denotes	Tbx15
T984	9097-9107	GO_PATO_EXT:biological_patterning_process_or_quality	denotes	patterning
T985	9111-9122	UBERON:0003104	denotes	mesenchymal
T986	9111-9128	CL:0000134	denotes	mesenchymal cells
T987	9123-9128	CL_GO_EXT:cell	denotes	cells
R2277	T3516	T3515	_lexicallyChainedTo	skin,area of
R3087	T4528	T4527	_lexicallyChainedTo	exons,portions of
R3663	T5379	T5378	_lexicallyChainedTo	head,mesenchymal tissues of
R3664	T5380	T5378	_lexicallyChainedTo	trunk,mesenchymal tissues of
R3665	T5381	T5378	_lexicallyChainedTo	limbs,mesenchymal tissues of
R5786	T8459	T8458	_lexicallyChainedTo	mesenchyme,periocular
R6402	T9297	T9296	_lexicallyChainedTo	cells,group of
R6403	T9300	T9299	_lexicallyChainedTo	cell population,proliferative expansion of
R6404	T9344	T9343	_lexicallyChainedTo	melanocyte,hair
R6405	T9358	T9357	_lexicallyChainedTo	development,limb
R6892	T10104	T10103	_lexicallyChainedTo	of,migration
R6893	T10104	T10106	_lexicallyChainedTo	of,proliferation
R6894	T10105	T10104	_lexicallyChainedTo	cells,of
R6895	T10107	T10104	_lexicallyChainedTo	cells,of
R8428	T12071	T12070	_lexicallyChainedTo	hairs,zigzag
R9497	T13553	T13552	_lexicallyChainedTo	mesoderm,lateral plate

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