PMC:3131100 / 2985-4302 JSONTXT

{"project":"2_test","denotations":[{"id":"21750625-20088628-76067980","span":{"begin":639,"end":640},"obj":"20088628"},{"id":"21750625-4832185-76067981","span":{"begin":702,"end":704},"obj":"4832185"},{"id":"21750625-630854-76067981","span":{"begin":702,"end":704},"obj":"630854"},{"id":"21750625-7811158-76067981","span":{"begin":702,"end":704},"obj":"7811158"},{"id":"21750625-8731071-76067981","span":{"begin":702,"end":704},"obj":"8731071"},{"id":"21750625-15060399-76067981","span":{"begin":702,"end":704},"obj":"15060399"},{"id":"21750625-15813645-76067982","span":{"begin":1315,"end":1317},"obj":"15813645"}],"text":"Noradrenergic symptom cluster and social dysfunction\nThe symptoms that are thought to be principally due to a deficit in noradrenergic transmission, the so-called noradrenergic symptom cluster, are those that result in social dysfunction (Figure 1). “Social dysfunction” is a collective term used to describe a variety of emotional problems experienced in social situations. It frequently leads to family disruption and social isolation. In the workplace it can lead to absenteeism and “presenteeism” (a term used to describe the lost productivity a worker experiences when he or she is able to attend work but is not performing optimally.9 Depression has a major negative impact on social functioning,10–14 which is possibly one of the most important factors affecting quality of life in depressed patients.\nIn the International Classification of Diseases, 10th Revision (ICD-10) and Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) diagnostic criteria of major depression, the item “lack of interests or pleasure” only partly covers the concept of decreased social ability. However, in addition to the simple presence of certain symptoms, DSM-IV requires that the symptoms should cause significant distress or impairment in social, occupational, or other important areas of functioning.15"}

{"project":"NEUROSES","denotations":[{"id":"T52","span":{"begin":185,"end":192},"obj":"CHEBI_33731"},{"id":"T53","span":{"begin":226,"end":237},"obj":"PATO_0001624"},{"id":"T54","span":{"begin":462,"end":466},"obj":"CHEBI_25016"},{"id":"T55","span":{"begin":462,"end":466},"obj":"CHEBI_27889"},{"id":"T56","span":{"begin":530,"end":534},"obj":"CHEBI_25434"},{"id":"T57","span":{"begin":602,"end":606},"obj":"PATO_0001026"},{"id":"T58","span":{"begin":770,"end":777},"obj":"PATO_0000001"},{"id":"T59","span":{"begin":953,"end":956},"obj":"CHEBI_38624"},{"id":"T60","span":{"begin":1168,"end":1171},"obj":"CHEBI_38624"},{"id":"T61","span":{"begin":1077,"end":1086},"obj":"PATO_0001997"},{"id":"T62","span":{"begin":1131,"end":1137},"obj":"PATO_0001503"},{"id":"T63","span":{"begin":1138,"end":1146},"obj":"PATO_0000070"},{"id":"T64","span":{"begin":641,"end":651},"obj":"PM3425"},{"id":"T65","span":{"begin":990,"end":1000},"obj":"PM3425"},{"id":"T66","span":{"begin":641,"end":651},"obj":"PM3425"},{"id":"T67","span":{"begin":990,"end":1000},"obj":"PM3425"}],"text":"Noradrenergic symptom cluster and social dysfunction\nThe symptoms that are thought to be principally due to a deficit in noradrenergic transmission, the so-called noradrenergic symptom cluster, are those that result in social dysfunction (Figure 1). “Social dysfunction” is a collective term used to describe a variety of emotional problems experienced in social situations. It frequently leads to family disruption and social isolation. In the workplace it can lead to absenteeism and “presenteeism” (a term used to describe the lost productivity a worker experiences when he or she is able to attend work but is not performing optimally.9 Depression has a major negative impact on social functioning,10–14 which is possibly one of the most important factors affecting quality of life in depressed patients.\nIn the International Classification of Diseases, 10th Revision (ICD-10) and Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) diagnostic criteria of major depression, the item “lack of interests or pleasure” only partly covers the concept of decreased social ability. However, in addition to the simple presence of certain symptoms, DSM-IV requires that the symptoms should cause significant distress or impairment in social, occupational, or other important areas of functioning.15"}