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{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/3091645","sourcedb":"PMC","sourceid":"3091645","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3091645","text":"The pivotal role that the prion protein (PrP) plays in transmissible spongiform encephalopathies (TSE) is now well established [[1,2] for recent reviews]. The conversion of this host-encoded protein to an abnormal, partially proteinase K resistant, isoform is a hallmark of most TSEs and PrP is the only known constituent of mammalian prions [3]. The Prnp gene that encodes for PrP, is expressed in a broad range of vertebrate tissues but most abundantly in the central nervous system [4].","tracks":[{"project":"2_test","denotations":[{"id":"20649983-17585315-10169575","span":{"begin":129,"end":130},"obj":"17585315"},{"id":"20649983-19399233-10169576","span":{"begin":131,"end":132},"obj":"19399233"},{"id":"20649983-6801762-10169577","span":{"begin":343,"end":344},"obj":"6801762"},{"id":"20649983-1346470-10169578","span":{"begin":486,"end":487},"obj":"1346470"}],"attributes":[{"subj":"20649983-17585315-10169575","pred":"source","obj":"2_test"},{"subj":"20649983-19399233-10169576","pred":"source","obj":"2_test"},{"subj":"20649983-6801762-10169577","pred":"source","obj":"2_test"},{"subj":"20649983-1346470-10169578","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#e293ec","default":true}]}]}}