PMC:3091642 / 17402-18856 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3091642","sourcedb":"PMC","sourceid":"3091642","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3091642","text":"The pattern of differential gene expression over time can provide insights into biologically functional relevance among genes. In the present study, a model-based clustering method [30] was used to cluster alteration patterns for the 789 differentially expressed genes in response to ILTV infection and revealed 7 gene clusters exhibiting distinct expression patterns (Figure 3 and Additional file 2). The 287 genes placed in cluster (C) 1 showed only nominal increases at 3 and 5 dpi followed by decreased expression levels at 7 dpi that were similar to those at the onset of the experiment. The C2 representing 97 genes exhibited a dramatic increase in gene expression only at 7 dpi, whereas the expression levels of the 90 genes in C3 progressively declined at 5 and 7 dpi. Three genes in C4 showed higher expression during early infection (1 dpi), sharp increases at 3 and 5 dpi, followed by a slight decline at 7 dpi. Expression patterns of 9 genes in C5 showed slightly lower expression at 1 dpi relative to the other time points, a dramatically increase at 3 and 5 dpi, followed by decreased expression at 7 dpi. The 85 genes in C6 showed lower expression at 1 dpi followed by a progressive increase during the later time points, which was opposite to 218 genes in C7 that showed higher expression at 1 dpi followed by decreased expression at 3, 5, and 7 dpi. GenBank accession numbers for genes in each cluster are shown in the Additional file 2.","tracks":[]}