PMC:3091639 / 21458-22264 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/3091639","sourcedb":"PMC","sourceid":"3091639","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3091639","text":"In this work, we applied computational analyses to explore the genome content and genetic diversity among the recently sequenced C. pneumoniae koala LPCoLN genome and previously published C. pneumoniae human genomes (AR39, CWL029, J138 and TW183). The koala LPCoLN genome is larger than all four C. pneumoniae human genomes by 10-12 kbp. We combined BLAST search methods and motif analysis for use in elucidating the relationship between gene function and evolution. Even though these techniques have several limitations [40], our comparative approach has (i) identified genome plasticity, (ii) provided circumstantial evidence for the presumed direction of C. pneumoniae evolution, and (iii) suggested targets for detection and differentiation of C. pneumoniae isolates from both human and animal origins.","tracks":[{"project":"2_test","denotations":[{"id":"20646324-17049238-10032195","span":{"begin":522,"end":524},"obj":"17049238"}],"attributes":[{"subj":"20646324-17049238-10032195","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ecb593","default":true}]}]}}