PMC:3062687 / 6708-9285 JSON TXT

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bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T5567	0-4	P25963	denotes	IκBα
T5568	21-25	P23396	denotes	RPS3
T5569	97-100	Q04864	denotes	Rel
T5570	117-121	P23396	denotes	RPS3
T5571	250-253	P21579	denotes	p65
T5572	250-253	Q04206	denotes	p65
T5573	289-293	P23396	denotes	RPS3
T5574	368-372	P23396	denotes	RPS3
T5575	438-441	P01375	denotes	TNF
T5576	501-505	P23396	denotes	RPS3
T5577	598-602	P25963	denotes	IκBα
T5578	654-657	Q04206	denotes	p65
T5579	654-657	P21579	denotes	p65
T5580	668-672	P23396	denotes	RPS3
T5581	677-681	P25963	denotes	IκBα
T5582	690-693	Q04206	denotes	p65
T5583	690-693	P21579	denotes	p65
T5584	751-755	P25963	denotes	IκBα
T5585	802-806	P23396	denotes	RPS3
T5586	839-843	P23396	denotes	RPS3
T5587	899-903	P25963	denotes	IκBα
T5588	910-914	P25963	denotes	IκBα
T5589	942-946	O14920	denotes	IKKβ
T5590	1024-1028	P25963	denotes	IκBα
T5591	1030-1033	P01375	denotes	TNF
T5592	1075-1079	P23396	denotes	RPS3
T5593	1178-1182	P23396	denotes	RPS3
T5594	1254-1258	P25963	denotes	IκBα
T5595	1289-1293	P25963	denotes	IκBα
T5596	1337-1341	P23396	denotes	RPS3
T5597	1382-1386	P23396	denotes	RPS3
T5598	1422-1426	P23396	denotes	RPS3
T5599	1442-1446	P25963	denotes	IκBα
T5600	1511-1515	P25963	denotes	IκBα
T5601	1536-1540	P25963	denotes	IκBα
T5602	1593-1597	P23396	denotes	RPS3
T5603	1678-1682	P23396	denotes	RPS3
T5604	1766-1770	P25963	denotes	IκBα
T5605	1868-1872	P23396	denotes	RPS3
T5606	1951-1955	P23396	denotes	RPS3
T5607	1974-1978	P25963	denotes	IκBα
T5608	2156-2160	P23396	denotes	RPS3
T5609	2167-2171	P25963	denotes	IκBα
T5610	2199-2202	P01375	denotes	TNF
T5611	2259-2263	P23396	denotes	RPS3
T5612	2302-2305	P01375	denotes	TNF
T5613	2341-2345	P25963	denotes	IκBα
T5614	2425-2429	P23396	denotes	RPS3
T5615	2535-2539	O14920	denotes	IKKβ
T5616	2559-2563	P23396	denotes	RPS3

2_test

Id	Subject	Object	Predicate	Lexical cue
21399639-18462924-74765156	109-111	18462924	denotes	23
21399639-18462924-74765156	109-111	18462924	denotes	23
21399639-15677444-74765157	113-115	15677444	denotes	24
21399639-15677444-74765157	113-115	15677444	denotes	24
21399639-18045535-74765158	267-268	18045535	denotes	6
21399639-18045535-74765158	267-268	18045535	denotes	6
21399639-8797825-74765159	1819-1821	8797825	denotes	25
21399639-8797825-74765159	1819-1821	8797825	denotes	25
21399639-17537731-74765159	1819-1821	17537731	denotes	25
21399639-17537731-74765159	1819-1821	17537731	denotes	25
21399639-12429743-74765159	1819-1821	12429743	denotes	25
21399639-12429743-74765159	1819-1821	12429743	denotes	25

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T5160	0-4	NN	denotes	IκBα
T5161	5-16	NN	denotes	degradation
T5162	17-20	CC	denotes	and
T5163	21-25	NN	denotes	RPS3
T5164	26-33	JJ	denotes	nuclear
T5165	34-47	NN	denotes	translocation
T5166	48-58	NN	denotes	Importin-α
T5167	59-68	VB	denotes	regulates
T5168	69-72	DT	denotes	the
T5169	73-80	JJ	denotes	nuclear
T5170	81-87	NN	denotes	import
T5171	88-90	IN	denotes	of
T5172	91-96	NN	denotes	NF-κB
T5173	97-100	NN	denotes	Rel
T5174	101-111	NN	denotes	subunits23
T5175	111-112	-COMMA-	denotes	,
T5176	113-115	CD	denotes	24
T5177	117-121	NN	denotes	RPS3
T5178	122-129	VB	denotes	harbors
T5179	130-131	DT	denotes	a
T5180	132-139	JJ	denotes	nuclear
T5181	140-152	NN	denotes	localization
T5182	153-159	NN	denotes	signal
T5183	160-161	-LRB-	denotes	(
T5184	161-164	NN	denotes	NLS
T5185	164-165	-RRB-	denotes	)
T5186	166-174	NN	denotes	sequence
T5187	175-178	CC	denotes	and
T5188	179-182	PRP-DOLLAR-	denotes	its
T5189	183-190	JJ	denotes	nuclear
T5190	191-204	NN	denotes	translocation
T5191	205-211	VB	denotes	occurs
T5192	212-214	IN	denotes	in
T5193	215-223	NN	denotes	parallel
T5194	224-226	TO	denotes	to
T5195	226-227	-COMMA-	denotes	,
T5196	228-231	CC	denotes	but
T5197	232-245	RB	denotes	independently
T5198	246-248	IN	denotes	of
T5199	248-249	-COMMA-	denotes	,
T5200	250-253	NN	denotes	p65
T5201	254-268	NN	denotes	translocation6
T5202	270-272	PRP	denotes	We
T5203	273-283	VB	denotes	envisioned
T5204	284-288	IN	denotes	that
T5205	289-293	NN	denotes	RPS3
T5206	294-299	MD	denotes	could
T5207	300-304	RB	denotes	also
T5208	305-312	VB	denotes	utilize
T5209	313-316	DT	denotes	the
T5210	317-329	JJ	denotes	importin-α/β
T5211	330-337	NN	denotes	pathway
T5212	339-349	JJ	denotes	Consistent
T5213	350-354	IN	denotes	with
T5214	355-359	DT	denotes	this
T5215	360-366	NN	denotes	notion
T5216	366-367	-COMMA-	denotes	,
T5217	368-372	NN	denotes	RPS3
T5218	373-384	NN	denotes	association
T5219	385-389	IN	denotes	with
T5220	390-400	NN	denotes	importin-α
T5221	400-401	-COMMA-	denotes	,
T5222	402-405	CC	denotes	but
T5223	406-409	RB	denotes	not
T5224	410-420	JJ	denotes	importin-β
T5225	420-421	-COMMA-	denotes	,
T5226	422-425	VB	denotes	was
T5227	426-434	VB	denotes	enhanced
T5228	435-437	IN	denotes	in
T5229	438-452	VB	denotes	TNF–stimulated
T5230	453-458	NN	denotes	cells
T5231	459-460	-LRB-	denotes	(
T5232	460-464	NN	denotes	Fig.
T5233	465-467	NN	denotes	3a
T5234	467-468	-RRB-	denotes	)
T5235	470-479	RB	denotes	Therefore
T5236	479-480	-COMMA-	denotes	,
T5237	481-483	PRP	denotes	we
T5238	484-492	VB	denotes	examined
T5239	493-500	IN	denotes	whether
T5240	501-505	NN	denotes	RPS3
T5241	506-513	NN	denotes	binding
T5242	514-516	TO	denotes	to
T5243	517-527	NN	denotes	importin-α
T5244	528-530	VB	denotes	is
T5245	531-540	JJ	denotes	essential
T5246	541-544	IN	denotes	for
T5247	545-552	JJ	denotes	nuclear
T5248	553-566	NN	denotes	translocation
T5249	567-573	IN	denotes	during
T5250	574-579	NN	denotes	NF-κB
T5251	580-590	NN	denotes	activation
T5252	592-597	IN	denotes	Since
T5253	598-602	NN	denotes	IκBα
T5254	603-614	NN	denotes	degradation
T5255	615-617	VB	denotes	is
T5256	618-619	DT	denotes	a
T5257	620-632	NN	denotes	prerequisite
T5258	633-635	TO	denotes	to
T5259	636-642	VB	denotes	unmask
T5260	643-646	DT	denotes	the
T5261	647-650	NN	denotes	NLS
T5262	651-653	IN	denotes	of
T5263	654-657	NN	denotes	p65
T5264	657-658	-COMMA-	denotes	,
T5265	659-662	CC	denotes	and
T5266	663-667	CC	denotes	both
T5267	668-672	NN	denotes	RPS3
T5268	673-676	CC	denotes	and
T5269	677-681	NN	denotes	IκBα
T5270	682-686	VB	denotes	bind
T5271	687-689	TO	denotes	to
T5272	690-693	NN	denotes	p65
T5273	694-696	IN	denotes	in
T5274	697-700	DT	denotes	the
T5275	701-712	JJ	denotes	cytoplasmic
T5276	713-723	JJ	denotes	inhibitory
T5277	724-731	NN	denotes	complex
T5278	731-732	-COMMA-	denotes	,
T5279	733-735	PRP	denotes	we
T5280	736-742	VB	denotes	tested
T5281	743-750	IN	denotes	whether
T5282	751-755	NN	denotes	IκBα
T5283	756-767	NN	denotes	degradation
T5284	768-770	VB	denotes	is
T5285	771-779	VB	denotes	required
T5286	780-783	IN	denotes	for
T5287	784-787	DT	denotes	the
T5288	788-798	NN	denotes	liberation
T5289	799-801	IN	denotes	of
T5290	802-806	NN	denotes	RPS3
T5291	808-810	PRP	denotes	We
T5292	811-819	VB	denotes	measured
T5293	820-823	DT	denotes	the
T5294	824-835	NN	denotes	association
T5295	836-838	IN	denotes	of
T5296	839-843	NN	denotes	RPS3
T5297	844-848	IN	denotes	with
T5298	849-859	NN	denotes	importin-α
T5299	860-862	IN	denotes	in
T5300	863-867	NN	denotes	293T
T5301	868-873	NN	denotes	cells
T5302	874-888	VB	denotes	overexpressing
T5303	889-898	JJ	denotes	wild-type
T5304	899-903	NN	denotes	IκBα
T5305	904-906	CC	denotes	or
T5306	907-909	DT	denotes	an
T5307	910-914	NN	denotes	IκBα
T5308	915-921	NN	denotes	mutant
T5309	922-923	-LRB-	denotes	(
T5310	923-927	NN	denotes	SSAA
T5311	927-928	-RRB-	denotes	)
T5312	929-938	JJ	denotes	resistant
T5313	939-941	TO	denotes	to
T5314	942-954	JJ	denotes	IKKβ-induced
T5315	955-970	NN	denotes	phosphorylation
T5316	971-974	CC	denotes	and
T5317	975-986	NN	denotes	degradation
T5318	988-990	IN	denotes	In
T5319	991-996	NN	denotes	cells
T5320	997-1008	VB	denotes	transfected
T5321	1009-1013	IN	denotes	with
T5322	1014-1023	JJ	denotes	wild-type
T5323	1024-1028	NN	denotes	IκBα
T5324	1028-1029	-COMMA-	denotes	,
T5325	1030-1033	NN	denotes	TNF
T5326	1034-1045	NN	denotes	stimulation
T5327	1046-1055	VB	denotes	augmented
T5328	1056-1059	DT	denotes	the
T5329	1060-1071	NN	denotes	interaction
T5330	1072-1074	IN	denotes	of
T5331	1075-1079	NN	denotes	RPS3
T5332	1080-1083	CC	denotes	and
T5333	1084-1094	JJ	denotes	importin-α
T5334	1095-1097	TO	denotes	to
T5335	1098-1099	DT	denotes	a
T5336	1100-1107	JJ	denotes	similar
T5337	1108-1114	NN	denotes	degree
T5338	1115-1117	IN	denotes	as
T5339	1118-1120	IN	denotes	in
T5340	1121-1136	JJ	denotes	non-transfected
T5341	1137-1142	NN	denotes	cells
T5342	1144-1146	IN	denotes	By
T5343	1147-1155	NN	denotes	contrast
T5344	1155-1156	-COMMA-	denotes	,
T5345	1157-1159	PRP	denotes	we
T5346	1160-1168	VB	denotes	observed
T5347	1169-1173	IN	denotes	that
T5348	1174-1177	DT	denotes	the
T5349	1178-1193	NN	denotes	RPS3-importin-α
T5350	1194-1205	NN	denotes	association
T5351	1206-1209	VB	denotes	was
T5352	1210-1219	VB	denotes	abolished
T5353	1220-1222	IN	denotes	by
T5354	1223-1226	DT	denotes	the
T5355	1227-1235	NN	denotes	presence
T5356	1236-1238	IN	denotes	of
T5357	1239-1253	JJ	denotes	non-degradable
T5358	1254-1258	NN	denotes	IκBα
T5359	1259-1260	-LRB-	denotes	(
T5360	1260-1264	NN	denotes	Fig.
T5361	1265-1267	NN	denotes	3b
T5362	1267-1268	-RRB-	denotes	)
T5363	1270-1272	TO	denotes	To
T5364	1273-1280	VB	denotes	examine
T5365	1281-1288	IN	denotes	whether
T5366	1289-1293	NN	denotes	IκBα
T5367	1294-1296	VB	denotes	is
T5368	1297-1300	DT	denotes	the
T5369	1301-1305	RB	denotes	only
T5370	1306-1317	JJ	denotes	cytoplasmic
T5371	1318-1325	NN	denotes	barrier
T5372	1326-1336	VB	denotes	precluding
T5373	1337-1341	NN	denotes	RPS3
T5374	1342-1349	JJ	denotes	nuclear
T5375	1350-1363	NN	denotes	translocation
T5376	1363-1364	-COMMA-	denotes	,
T5377	1365-1367	PRP	denotes	we
T5378	1368-1376	VB	denotes	measured
T5379	1377-1381	CC	denotes	both
T5380	1382-1397	NN	denotes	RPS3-importin-α
T5381	1398-1409	NN	denotes	association
T5382	1410-1413	CC	denotes	and
T5383	1414-1421	JJ	denotes	nuclear
T5384	1422-1426	NN	denotes	RPS3
T5385	1427-1432	IN	denotes	after
T5386	1433-1441	VB	denotes	reducing
T5387	1442-1446	NN	denotes	IκBα
T5388	1447-1457	NN	denotes	expression
T5389	1459-1467	VB	denotes	Compared
T5390	1468-1472	IN	denotes	with
T5391	1473-1484	JJ	denotes	nonspecific
T5392	1485-1490	NN	denotes	siRNA
T5393	1490-1491	-COMMA-	denotes	,
T5394	1492-1497	NN	denotes	siRNA
T5395	1498-1507	NN	denotes	targeting
T5396	1508-1510	IN	denotes	of
T5397	1511-1515	NN	denotes	IκBα
T5398	1516-1526	RB	denotes	completely
T5399	1527-1535	VB	denotes	depleted
T5400	1536-1540	NN	denotes	IκBα
T5401	1541-1543	IN	denotes	in
T5402	1544-1550	NN	denotes	Jurkat
T5403	1551-1556	NN	denotes	cells
T5404	1557-1558	-LRB-	denotes	(
T5405	1558-1562	NN	denotes	Fig.
T5406	1563-1565	NN	denotes	3c
T5407	1565-1566	-COMMA-	denotes	,
T5408	1567-1572	NN	denotes	input
T5409	1572-1573	-RRB-	denotes	)
T5410	1575-1587	RB	denotes	Nevertheless
T5411	1587-1588	-COMMA-	denotes	,
T5412	1589-1592	DT	denotes	the
T5413	1593-1608	NN	denotes	RPS3-importin-α
T5414	1609-1620	NN	denotes	association
T5415	1621-1624	VB	denotes	was
T5416	1625-1628	RB	denotes	not
T5417	1629-1638	JJ	denotes	augmented
T5418	1639-1640	-LRB-	denotes	(
T5419	1640-1644	NNP	denotes	Fig.
T5420	1645-1647	NN	denotes	3c
T5421	1647-1648	-RRB-	denotes	)
T5422	1648-1649	-COMMA-	denotes	,
T5423	1650-1653	CC	denotes	nor
T5424	1654-1657	VB	denotes	was
T5425	1658-1669	JJ	denotes	significant
T5426	1670-1677	JJ	denotes	nuclear
T5427	1678-1682	NN	denotes	RPS3
T5428	1683-1691	VB	denotes	detected
T5429	1692-1693	-LRB-	denotes	(
T5430	1693-1697	NNP	denotes	Fig.
T5431	1698-1700	NNP	denotes	3d
T5432	1700-1701	-RRB-	denotes	)
T5433	1703-1711	RB	denotes	Moreover
T5434	1711-1712	-COMMA-	denotes	,
T5435	1713-1718	NN	denotes	cells
T5436	1719-1726	VB	denotes	treated
T5437	1727-1731	IN	denotes	with
T5438	1732-1738	NN	denotes	sodium
T5439	1739-1750	NN	denotes	pervanadate
T5440	1751-1752	-LRB-	denotes	(
T5441	1752-1754	NN	denotes	Pv
T5442	1754-1755	-RRB-	denotes	)
T5443	1756-1758	TO	denotes	to
T5444	1759-1765	VB	denotes	induce
T5445	1766-1770	NN	denotes	IκBα
T5446	1771-1782	NN	denotes	degradation
T5447	1783-1790	IN	denotes	through
T5448	1791-1793	DT	denotes	an
T5449	1794-1809	JJ	denotes	IKK-independent
T5450	1810-1824	NN	denotes	mechanism25-27
T5451	1825-1828	VB	denotes	did
T5452	1829-1832	RB	denotes	not
T5453	1833-1837	VB	denotes	show
T5454	1838-1847	VB	denotes	increased
T5455	1848-1859	NN	denotes	association
T5456	1860-1867	IN	denotes	between
T5457	1868-1872	NN	denotes	RPS3
T5458	1873-1876	CC	denotes	and
T5459	1877-1887	NN	denotes	importin-α
T5460	1888-1889	-LRB-	denotes	(
T5461	1889-1893	NN	denotes	Fig.
T5462	1894-1896	NN	denotes	3e
T5463	1897-1900	CC	denotes	and
T5464	1901-1914	NNP	denotes	Supplementary
T5465	1915-1919	NNP	denotes	Fig.
T5466	1920-1922	NN	denotes	3b
T5467	1922-1923	-RRB-	denotes	)
T5468	1924-1926	CC	denotes	or
T5469	1927-1934	JJ	denotes	nuclear
T5470	1935-1947	NN	denotes	accumulation
T5471	1948-1950	IN	denotes	of
T5472	1951-1955	NN	denotes	RPS3
T5473	1955-1956	-COMMA-	denotes	,
T5474	1957-1964	IN	denotes	despite
T5475	1965-1973	JJ	denotes	complete
T5476	1974-1978	NN	denotes	IκBα
T5477	1979-1990	NN	denotes	degradation
T5478	1991-1992	-LRB-	denotes	(
T5479	1992-2005	NNP	denotes	Supplementary
T5480	2006-2010	NNP	denotes	Fig.
T5481	2011-2013	NN	denotes	3c
T5482	2013-2014	-RRB-	denotes	)
T5483	2016-2018	PRP	denotes	We
T5484	2019-2026	RB	denotes	further
T5485	2027-2035	VB	denotes	examined
T5486	2036-2043	IN	denotes	whether
T5487	2044-2045	DT	denotes	a
T5488	2046-2056	JJ	denotes	subsequent
T5489	2057-2062	NN	denotes	NF-κB
T5490	2063-2073	NN	denotes	activation
T5491	2074-2080	NN	denotes	signal
T5492	2081-2094	RB	denotes	independently
T5493	2095-2103	VB	denotes	promotes
T5494	2104-2107	DT	denotes	the
T5495	2108-2118	JJ	denotes	importin-α
T5496	2119-2130	NN	denotes	association
T5497	2131-2134	CC	denotes	and
T5498	2135-2142	JJ	denotes	nuclear
T5499	2143-2152	NN	denotes	transport
T5500	2153-2155	IN	denotes	of
T5501	2156-2160	NN	denotes	RPS3
T5502	2161-2166	IN	denotes	after
T5503	2167-2171	NN	denotes	IκBα
T5504	2172-2183	NN	denotes	degradation
T5505	2185-2187	PRP	denotes	We
T5506	2188-2193	VB	denotes	found
T5507	2194-2198	IN	denotes	that
T5508	2199-2202	NN	denotes	TNF
T5509	2203-2214	NN	denotes	stimulation
T5510	2215-2224	VB	denotes	following
T5511	2225-2227	NN	denotes	Pv
T5512	2228-2237	NN	denotes	treatment
T5513	2238-2241	VB	denotes	was
T5514	2242-2250	VB	denotes	required
T5515	2251-2254	IN	denotes	for
T5516	2255-2258	DT	denotes	the
T5517	2259-2274	NN	denotes	RPS3-importin-α
T5518	2275-2286	NN	denotes	association
T5519	2286-2287	-COMMA-	denotes	,
T5520	2288-2298	JJ	denotes	comparable
T5521	2299-2301	TO	denotes	to
T5522	2302-2305	NN	denotes	TNF
T5523	2306-2317	NN	denotes	stimulation
T5524	2318-2323	RB	denotes	alone
T5525	2324-2325	-LRB-	denotes	(
T5526	2325-2329	NNP	denotes	Fig.
T5527	2330-2332	NN	denotes	3e
T5528	2332-2333	-RRB-	denotes	)
T5529	2335-2339	RB	denotes	Thus
T5530	2339-2340	-COMMA-	denotes	,
T5531	2341-2345	NN	denotes	IκBα
T5532	2346-2361	NN	denotes	phosphorylation
T5533	2362-2365	CC	denotes	and
T5534	2366-2377	NN	denotes	degradation
T5535	2378-2384	PRP	denotes	itself
T5536	2385-2387	VB	denotes	is
T5537	2388-2396	VB	denotes	required
T5538	2397-2400	CC	denotes	but
T5539	2401-2404	RB	denotes	not
T5540	2405-2415	JJ	denotes	sufficient
T5541	2416-2418	TO	denotes	to
T5542	2419-2424	VB	denotes	cause
T5543	2425-2429	NN	denotes	RPS3
T5544	2430-2441	NN	denotes	association
T5545	2442-2446	IN	denotes	with
T5546	2447-2457	NN	denotes	importin-α
T5547	2458-2466	VB	denotes	followed
T5548	2467-2469	IN	denotes	by
T5549	2470-2477	JJ	denotes	nuclear
T5550	2478-2491	NN	denotes	translocation
T5551	2493-2499	RB	denotes	Rather
T5552	2499-2500	-COMMA-	denotes	,
T5553	2501-2503	DT	denotes	an
T5554	2504-2514	JJ	denotes	additional
T5555	2515-2521	NN	denotes	signal
T5556	2521-2522	-COMMA-	denotes	,
T5557	2523-2534	RB	denotes	potentially
T5558	2535-2539	NN	denotes	IKKβ
T5559	2540-2555	NN	denotes	phosphorylation
T5560	2556-2558	IN	denotes	of
T5561	2559-2563	NN	denotes	RPS3
T5562	2563-2564	-COMMA-	denotes	,
T5563	2565-2567	VB	denotes	is
T5564	2568-2576	VB	denotes	required
R4092	T5161	T5160	arg1Of	degradation,IκBα
R4093	T5161	T5162	arg1Of	degradation,and
R4094	T5165	T5162	arg2Of	translocation,and
R4095	T5165	T5163	arg1Of	translocation,RPS3
R4096	T5165	T5164	arg1Of	translocation,nuclear
R4097	T5166	T5167	arg1Of	Importin-α,regulates
R4100	T5170	T5167	arg2Of	import,regulates
R4101	T5170	T5168	arg1Of	import,the
R4102	T5174	T5171	arg2Of	subunits23,of
R4103	T5174	T5172	arg1Of	subunits23,NF-κB
R4104	T5174	T5173	arg1Of	subunits23,Rel
R4105	T5174	T5175	arg1Of	subunits23,","
R4106	T5176	T5175	arg2Of	24,","
R4107	T5177	T5178	arg1Of	RPS3,harbors
R4108	T5178	T5187	arg1Of	harbors,and
R4109	T5182	T5180	arg1Of	signal,nuclear
R4110	T5182	T5181	arg1Of	signal,localization
R4111	T5182	T5183	arg1Of	signal,(
R4112	T5184	T5183	arg2Of	NLS,(
R4113	T5185	T5183	arg3Of	),(
R4114	T5186	T5178	arg2Of	sequence,harbors
R4115	T5186	T5179	arg1Of	sequence,a
R4116	T5186	T5182	arg1Of	sequence,signal
R4117	T5190	T5188	arg1Of	translocation,its
R4118	T5190	T5189	arg1Of	translocation,nuclear
R4119	T5190	T5191	arg1Of	translocation,occurs
R4120	T5191	T5187	arg2Of	occurs,and
R4121	T5191	T5192	arg1Of	occurs,in
R4122	T5191	T5194	arg1Of	occurs,to
R4123	T5191	T5198	arg1Of	occurs,of
R4124	T5193	T5192	arg2Of	parallel,in
R4125	T5194	T5196	arg1Of	to,but
R4126	T5196	T5195	arg1Of	but,","
R4127	T5198	T5196	arg2Of	of,but
R4128	T5198	T5197	arg1Of	of,independently
R4129	T5198	T5199	arg1Of	of,","
R4130	T5201	T5198	arg2Of	translocation6,of
R4131	T5201	T5200	arg1Of	translocation6,p65
R4132	T5202	T5203	arg1Of	We,envisioned
R4133	T5205	T5206	arg1Of	RPS3,could
R4134	T5205	T5208	arg1Of	RPS3,utilize
R4135	T5208	T5203	arg2Of	utilize,envisioned
R4136	T5208	T5204	arg1Of	utilize,that
R4137	T5208	T5206	arg2Of	utilize,could
R4138	T5208	T5207	arg1Of	utilize,also
R4139	T5211	T5208	arg2Of	pathway,utilize
R4140	T5211	T5209	arg1Of	pathway,the
R4141	T5211	T5210	arg1Of	pathway,importin-α/β
R4142	T5212	T5213	arg1Of	Consistent,with
R4143	T5215	T5213	arg2Of	notion,with
R4144	T5215	T5214	arg1Of	notion,this
R4145	T5218	T5217	arg1Of	association,RPS3
R4146	T5218	T5219	arg1Of	association,with
R4147	T5218	T5226	arg1Of	association,was
R4148	T5218	T5227	arg2Of	association,enhanced
R4149	T5220	T5222	arg1Of	importin-α,but
R4150	T5222	T5219	arg2Of	but,with
R4151	T5222	T5221	arg1Of	but,","
R4152	T5222	T5223	arg1Of	but,not
R4153	T5224	T5222	arg2Of	importin-β,but
R4154	T5227	T5212	arg1Of	enhanced,Consistent
R4155	T5227	T5216	arg1Of	enhanced,","
R4156	T5227	T5225	arg1Of	enhanced,","
R4157	T5227	T5226	arg2Of	enhanced,was
R4158	T5227	T5228	arg1Of	enhanced,in
R4159	T5230	T5228	arg2Of	cells,in
R4160	T5230	T5229	arg2Of	cells,TNF–stimulated
R4161	T5230	T5231	arg1Of	cells,(
R4162	T5233	T5231	arg2Of	3a,(
R4163	T5233	T5232	arg1Of	3a,Fig.
R4164	T5234	T5231	arg3Of	),(
R4165	T5237	T5238	arg1Of	we,examined
R4166	T5238	T5235	arg1Of	examined,Therefore
R4167	T5238	T5236	arg1Of	examined,","
R4168	T5241	T5240	arg1Of	binding,RPS3
R4169	T5241	T5242	arg1Of	binding,to
R4170	T5241	T5244	arg1Of	binding,is
R4171	T5241	T5245	arg1Of	binding,essential
R4172	T5243	T5242	arg2Of	importin-α,to
R4173	T5244	T5238	arg2Of	is,examined
R4174	T5244	T5239	arg1Of	is,whether
R4175	T5245	T5244	arg2Of	essential,is
R4176	T5245	T5246	arg1Of	essential,for
R4177	T5245	T5249	arg1Of	essential,during
R4178	T5248	T5246	arg2Of	translocation,for
R4179	T5248	T5247	arg1Of	translocation,nuclear
R4180	T5251	T5249	arg2Of	activation,during
R4181	T5251	T5250	arg1Of	activation,NF-κB
R4182	T5254	T5253	arg1Of	degradation,IκBα
R4183	T5254	T5255	arg1Of	degradation,is
R4184	T5255	T5265	arg1Of	is,and
R4185	T5257	T5255	arg2Of	prerequisite,is
R4186	T5257	T5256	arg1Of	prerequisite,a
R4187	T5257	T5258	modOf	prerequisite,to
R4188	T5259	T5258	arg1Of	unmask,to
R4189	T5261	T5259	arg2Of	NLS,unmask
R4190	T5261	T5260	arg1Of	NLS,the
R4191	T5261	T5262	arg1Of	NLS,of
R4192	T5263	T5262	arg2Of	p65,of
R4193	T5265	T5252	arg2Of	and,Since
R4194	T5265	T5264	arg1Of	and,","
R4195	T5267	T5268	arg1Of	RPS3,and
R4196	T5268	T5266	arg1Of	and,both
R4197	T5268	T5270	arg1Of	and,bind
R4198	T5269	T5268	arg2Of	IκBα,and
R4199	T5270	T5265	arg2Of	bind,and
R4200	T5270	T5271	arg1Of	bind,to
R4201	T5270	T5273	arg1Of	bind,in
R4202	T5272	T5271	arg2Of	p65,to
R4203	T5277	T5273	arg2Of	complex,in
R4204	T5277	T5274	arg1Of	complex,the
R4205	T5277	T5275	arg1Of	complex,cytoplasmic
R4206	T5277	T5276	arg1Of	complex,inhibitory
R4207	T5279	T5280	arg1Of	we,tested
R4208	T5280	T5252	arg1Of	tested,Since
R4209	T5280	T5278	arg1Of	tested,","
R4210	T5283	T5282	arg1Of	degradation,IκBα
R4211	T5283	T5284	arg1Of	degradation,is
R4212	T5283	T5285	arg2Of	degradation,required
R4213	T5285	T5280	arg2Of	required,tested
R4214	T5285	T5281	arg1Of	required,whether
R4215	T5285	T5284	arg2Of	required,is
R4216	T5285	T5286	arg1Of	required,for
R4217	T5288	T5286	arg2Of	liberation,for
R4218	T5288	T5287	arg1Of	liberation,the
R4219	T5288	T5289	arg1Of	liberation,of
R4220	T5290	T5289	arg2Of	RPS3,of
R4221	T5291	T5292	arg1Of	We,measured
R4222	T5294	T5293	arg1Of	association,the
R4223	T5294	T5295	arg1Of	association,of
R4224	T5294	T5297	arg1Of	association,with
R4225	T5294	T5299	arg1Of	association,in
R4226	T5294	T5305	arg1Of	association,or
R4227	T5296	T5295	arg2Of	RPS3,of
R4228	T5298	T5297	arg2Of	importin-α,with
R4229	T5301	T5299	arg2Of	cells,in
R4230	T5301	T5300	arg1Of	cells,293T
R4231	T5301	T5302	arg1Of	cells,overexpressing
R4232	T5304	T5302	arg2Of	IκBα,overexpressing
R4233	T5304	T5303	arg1Of	IκBα,wild-type
R4234	T5305	T5292	arg2Of	or,measured
R4235	T5308	T5305	arg2Of	mutant,or
R4236	T5308	T5306	arg1Of	mutant,an
R4237	T5308	T5307	arg1Of	mutant,IκBα
R4238	T5308	T5309	arg1Of	mutant,(
R4239	T5308	T5312	arg1Of	mutant,resistant
R4240	T5310	T5309	arg2Of	SSAA,(
R4241	T5311	T5309	arg3Of	),(
R4242	T5312	T5313	arg1Of	resistant,to
R4243	T5315	T5316	arg1Of	phosphorylation,and
R4244	T5316	T5313	arg2Of	and,to
R4245	T5316	T5314	arg1Of	and,IKKβ-induced
R4246	T5317	T5316	arg2Of	degradation,and
R4247	T5319	T5318	arg2Of	cells,In
R4248	T5319	T5320	arg2Of	cells,transfected
R4249	T5320	T5321	arg1Of	transfected,with
R4250	T5323	T5321	arg2Of	IκBα,with
R4251	T5323	T5322	arg1Of	IκBα,wild-type
R4252	T5326	T5325	arg1Of	stimulation,TNF
R4253	T5326	T5327	arg1Of	stimulation,augmented
R4254	T5327	T5318	arg1Of	augmented,In
R4255	T5327	T5324	arg1Of	augmented,","
R4256	T5329	T5327	arg2Of	interaction,augmented
R4257	T5329	T5328	arg1Of	interaction,the
R4258	T5329	T5330	arg1Of	interaction,of
R4259	T5331	T5332	arg1Of	RPS3,and
R4260	T5333	T5332	arg2Of	importin-α,and
R4261	T5333	T5334	arg1Of	importin-α,to
R4262	T5333	T5339	arg1Of	importin-α,in
R4263	T5337	T5334	arg2Of	degree,to
R4264	T5337	T5335	arg1Of	degree,a
R4265	T5337	T5336	arg1Of	degree,similar
R4266	T5339	T5338	arg1Of	in,as
R4267	T5340	T5339	arg2Of	non-transfected,in
R4268	T5341	T5330	arg2Of	cells,of
R4269	T5341	T5331	arg1Of	cells,RPS3
R4270	T5341	T5333	arg1Of	cells,importin-α
R4271	T5343	T5342	arg2Of	contrast,By
R4272	T5345	T5346	arg1Of	we,observed
R4273	T5346	T5342	arg1Of	observed,By
R4274	T5346	T5344	arg1Of	observed,","
R4275	T5350	T5348	arg1Of	association,the
R4276	T5350	T5349	arg1Of	association,RPS3-importin-α
R4277	T5350	T5351	arg1Of	association,was
R4278	T5350	T5352	arg2Of	association,abolished
R4279	T5352	T5346	arg2Of	abolished,observed
R4280	T5352	T5347	arg1Of	abolished,that
R4281	T5352	T5351	arg2Of	abolished,was
R4282	T5355	T5352	arg1Of	presence,abolished
R4283	T5355	T5353	arg2Of	presence,by
R4284	T5355	T5354	arg1Of	presence,the
R4285	T5355	T5356	arg1Of	presence,of
R4286	T5358	T5356	arg2Of	IκBα,of
R4287	T5358	T5357	arg1Of	IκBα,non-degradable
R4288	T5358	T5359	arg1Of	IκBα,(
R4289	T5361	T5359	arg2Of	3b,(
R4290	T5361	T5360	arg1Of	3b,Fig.
R4291	T5362	T5359	arg3Of	),(
R4292	T5364	T5363	arg1Of	examine,To
R4293	T5366	T5367	arg1Of	IκBα,is
R4294	T5367	T5364	arg2Of	is,examine
R4295	T5367	T5365	arg1Of	is,whether
R4296	T5371	T5367	arg2Of	barrier,is
R4297	T5371	T5368	arg1Of	barrier,the
R4298	T5371	T5369	arg1Of	barrier,only
R4299	T5371	T5370	arg1Of	barrier,cytoplasmic
R4300	T5371	T5372	arg1Of	barrier,precluding
R4301	T5375	T5372	arg2Of	translocation,precluding
R4302	T5375	T5373	arg1Of	translocation,RPS3
R4303	T5375	T5374	arg1Of	translocation,nuclear
R4304	T5377	T5364	arg1Of	we,examine
R4305	T5377	T5378	arg1Of	we,measured
R4306	T5377	T5386	arg1Of	we,reducing
R4307	T5378	T5363	modOf	measured,To
R4308	T5378	T5376	arg1Of	measured,","
R4309	T5378	T5385	arg1Of	measured,after
R4310	T5381	T5380	arg1Of	association,RPS3-importin-α
R4311	T5381	T5382	arg1Of	association,and
R4312	T5382	T5378	arg2Of	and,measured
R4313	T5382	T5379	arg1Of	and,both
R4314	T5384	T5382	arg2Of	RPS3,and
R4315	T5384	T5383	arg1Of	RPS3,nuclear
R4316	T5386	T5385	arg2Of	reducing,after
R4317	T5388	T5386	arg2Of	expression,reducing
R4318	T5388	T5387	arg1Of	expression,IκBα
R4319	T5390	T5389	arg2Of	with,Compared
R4320	T5392	T5390	arg2Of	siRNA,with
R4321	T5392	T5391	arg1Of	siRNA,nonspecific
R4322	T5395	T5394	arg1Of	targeting,siRNA
R4323	T5395	T5396	arg1Of	targeting,of
R4324	T5395	T5399	arg1Of	targeting,depleted
R4325	T5397	T5396	arg2Of	IκBα,of
R4326	T5399	T5389	arg1Of	depleted,Compared
R4327	T5399	T5393	arg1Of	depleted,","
R4328	T5399	T5398	arg1Of	depleted,completely
R4329	T5399	T5401	arg1Of	depleted,in
R4330	T5400	T5399	arg2Of	IκBα,depleted
R4331	T5403	T5401	arg2Of	cells,in
R4332	T5403	T5402	arg1Of	cells,Jurkat
R4333	T5403	T5404	arg1Of	cells,(
R4334	T5406	T5404	arg2Of	3c,(
R4335	T5406	T5405	arg1Of	3c,Fig.
R4336	T5406	T5407	arg1Of	3c,","
R4337	T5408	T5407	arg2Of	input,","
R4338	T5409	T5404	arg3Of	),(
R4339	T5414	T5412	arg1Of	association,the
R4340	T5414	T5413	arg1Of	association,RPS3-importin-α
R4341	T5414	T5415	arg1Of	association,was
R4342	T5414	T5417	arg1Of	association,augmented
R4343	T5414	T5424	arg1Of	association,was
R4344	T5415	T5416	arg1Of	was,not
R4345	T5415	T5423	arg1Of	was,nor
R4346	T5417	T5415	arg2Of	augmented,was
R4347	T5417	T5418	arg1Of	augmented,(
R4348	T5420	T5418	arg2Of	3c,(
R4349	T5420	T5419	arg1Of	3c,Fig.
R4350	T5421	T5418	arg3Of	),(
R4351	T5423	T5410	arg1Of	nor,Nevertheless
R4352	T5423	T5411	arg1Of	nor,","
R4353	T5423	T5422	arg1Of	nor,","
R4354	T5424	T5423	arg2Of	was,nor
R4355	T5426	T5425	arg1Of	nuclear,significant
R4356	T5427	T5424	arg2Of	RPS3,was
R4357	T5427	T5426	arg1Of	RPS3,nuclear
R4358	T5427	T5428	arg2Of	RPS3,detected
R4359	T5428	T5429	arg1Of	detected,(
R4360	T5431	T5429	arg2Of	3d,(
R4361	T5431	T5430	arg1Of	3d,Fig.
R4362	T5432	T5429	arg3Of	),(
R4363	T5435	T5436	arg2Of	cells,treated
R4364	T5435	T5451	arg1Of	cells,did
R4365	T5435	T5453	arg1Of	cells,show
R4366	T5436	T5437	arg1Of	treated,with
R4367	T5439	T5437	arg2Of	pervanadate,with
R4368	T5439	T5438	arg1Of	pervanadate,sodium
R4369	T5439	T5440	arg1Of	pervanadate,(
R4370	T5439	T5443	modOf	pervanadate,to
R4371	T5441	T5440	arg2Of	Pv,(
R4372	T5442	T5440	arg3Of	),(
R4373	T5444	T5443	arg1Of	induce,to
R4374	T5444	T5447	arg1Of	induce,through
R4375	T5446	T5444	arg2Of	degradation,induce
R4376	T5446	T5445	arg1Of	degradation,IκBα
R4377	T5450	T5447	arg2Of	mechanism25-27,through
R4378	T5450	T5448	arg1Of	mechanism25-27,an
R4379	T5450	T5449	arg1Of	mechanism25-27,IKK-independent
R4380	T5453	T5433	arg1Of	show,Moreover
R4381	T5453	T5434	arg1Of	show,","
R4382	T5453	T5451	arg2Of	show,did
R4383	T5453	T5452	arg1Of	show,not
R4384	T5453	T5473	arg1Of	show,","
R4385	T5453	T5474	arg1Of	show,despite
R4386	T5455	T5453	arg2Of	association,show
R4387	T5455	T5454	arg2Of	association,increased
R4388	T5455	T5456	arg1Of	association,between
R4389	T5457	T5458	arg1Of	RPS3,and
R4390	T5458	T5456	arg2Of	and,between
R4391	T5459	T5460	arg1Of	importin-α,(
R4392	T5459	T5468	arg1Of	importin-α,or
R4393	T5462	T5461	arg1Of	3e,Fig.
R4394	T5462	T5463	arg1Of	3e,and
R4395	T5463	T5460	arg2Of	and,(
R4396	T5465	T5464	arg1Of	Fig.,Supplementary
R4397	T5466	T5463	arg2Of	3b,and
R4398	T5466	T5465	arg1Of	3b,Fig.
R4399	T5467	T5460	arg3Of	),(
R4400	T5468	T5458	arg2Of	or,and
R4401	T5470	T5468	arg2Of	accumulation,or
R4402	T5470	T5469	arg1Of	accumulation,nuclear
R4403	T5470	T5471	arg1Of	accumulation,of
R4404	T5472	T5471	arg2Of	RPS3,of
R4405	T5477	T5474	arg2Of	degradation,despite
R4406	T5477	T5475	arg1Of	degradation,complete
R4407	T5477	T5476	arg1Of	degradation,IκBα
R4408	T5477	T5478	arg1Of	degradation,(
R4409	T5480	T5479	arg1Of	Fig.,Supplementary
R4410	T5481	T5478	arg2Of	3c,(
R4411	T5481	T5480	arg1Of	3c,Fig.
R4412	T5482	T5478	arg3Of	),(
R4413	T5483	T5485	arg1Of	We,examined
R4414	T5485	T5484	arg1Of	examined,further
R4415	T5491	T5487	arg1Of	signal,a
R4416	T5491	T5488	arg1Of	signal,subsequent
R4417	T5491	T5489	arg1Of	signal,NF-κB
R4418	T5491	T5490	arg1Of	signal,activation
R4419	T5491	T5493	arg1Of	signal,promotes
R4420	T5493	T5485	arg2Of	promotes,examined
R4421	T5493	T5486	arg1Of	promotes,whether
R4422	T5493	T5492	arg1Of	promotes,independently
R4423	T5493	T5502	arg1Of	promotes,after
R4424	T5496	T5494	arg1Of	association,the
R4425	T5496	T5495	arg1Of	association,importin-α
R4426	T5496	T5497	arg1Of	association,and
R4427	T5497	T5493	arg2Of	and,promotes
R4428	T5499	T5497	arg2Of	transport,and
R4429	T5499	T5498	arg1Of	transport,nuclear
R4430	T5499	T5500	arg1Of	transport,of
R4431	T5501	T5500	arg2Of	RPS3,of
R4432	T5504	T5502	arg2Of	degradation,after
R4433	T5504	T5503	arg1Of	degradation,IκBα
R4434	T5505	T5506	arg1Of	We,found
R4435	T5509	T5508	arg1Of	stimulation,TNF
R4436	T5509	T5510	arg1Of	stimulation,following
R4437	T5509	T5513	arg1Of	stimulation,was
R4438	T5509	T5514	arg2Of	stimulation,required
R4439	T5512	T5510	arg2Of	treatment,following
R4440	T5512	T5511	arg1Of	treatment,Pv
R4441	T5514	T5506	arg2Of	required,found
R4442	T5514	T5507	arg1Of	required,that
R4443	T5514	T5513	arg2Of	required,was
R4444	T5514	T5515	arg1Of	required,for
R4445	T5518	T5515	arg2Of	association,for
R4446	T5518	T5516	arg1Of	association,the
R4447	T5518	T5517	arg1Of	association,RPS3-importin-α
R4448	T5518	T5519	arg1Of	association,","
R4449	T5518	T5520	arg1Of	association,comparable
R4450	T5520	T5521	arg1Of	comparable,to
R4451	T5523	T5521	arg2Of	stimulation,to
R4452	T5523	T5522	arg1Of	stimulation,TNF
R4453	T5523	T5524	arg1Of	stimulation,alone
R4454	T5523	T5525	arg1Of	stimulation,(
R4455	T5527	T5525	arg2Of	3e,(
R4456	T5527	T5526	arg1Of	3e,Fig.
R4457	T5528	T5525	arg3Of	),(
R4458	T5532	T5531	arg1Of	phosphorylation,IκBα
R4459	T5532	T5533	arg1Of	phosphorylation,and
R4460	T5533	T5536	arg1Of	and,is
R4461	T5533	T5537	arg2Of	and,required
R4462	T5533	T5540	arg1Of	and,sufficient
R4463	T5534	T5533	arg2Of	degradation,and
R4464	T5534	T5535	arg1Of	degradation,itself
R4465	T5537	T5538	arg1Of	required,but
R4466	T5538	T5529	arg1Of	but,Thus
R4467	T5538	T5530	arg1Of	but,","
R4468	T5538	T5536	arg2Of	but,is
R4469	T5538	T5541	modOf	but,to
R4470	T5540	T5538	arg2Of	sufficient,but
R4471	T5540	T5539	arg1Of	sufficient,not
R4472	T5542	T5541	arg1Of	cause,to
R4473	T5544	T5542	arg2Of	association,cause
R4474	T5544	T5543	arg1Of	association,RPS3
R4475	T5544	T5545	arg1Of	association,with
R4476	T5546	T5545	arg2Of	importin-α,with
R4477	T5546	T5547	arg2Of	importin-α,followed
R4478	T5550	T5547	arg1Of	translocation,followed
R4479	T5550	T5548	arg2Of	translocation,by
R4480	T5550	T5549	arg1Of	translocation,nuclear
R4481	T5555	T5553	arg1Of	signal,an
R4482	T5555	T5554	arg1Of	signal,additional
R4483	T5555	T5556	arg1Of	signal,","
R4484	T5555	T5563	arg1Of	signal,is
R4485	T5555	T5564	arg2Of	signal,required
R4486	T5559	T5556	arg2Of	phosphorylation,","
R4487	T5559	T5557	arg1Of	phosphorylation,potentially
R4488	T5559	T5558	arg1Of	phosphorylation,IKKβ
R4489	T5559	T5560	arg1Of	phosphorylation,of
R4490	T5561	T5560	arg2Of	RPS3,of
R4491	T5564	T5551	arg1Of	required,Rather
R4492	T5564	T5552	arg1Of	required,","
R4493	T5564	T5562	arg1Of	required,","
R4494	T5564	T5563	arg2Of	required,is
R4098	T5170	T5169	arg1Of	import,nuclear
R4099	T5170	T5171	arg1Of	import,of

bionlp-st-ge-2016-coref

Id	Subject	Object	Predicate	Lexical cue
T5565	179-182	Anaphor	denotes	its
T5566	117-121	Antecedent	denotes	RPS3
R4495	T5565	T5566	boundBy	its,RPS3

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T5617	0-4	NNP	denotes	IκBα
T5618	5-16	NN	denotes	degradation
T5619	17-20	CC	denotes	and
T5620	21-25	JJ	denotes	RPS3
T5621	26-33	JJ	denotes	nuclear
T5622	34-47	NN	denotes	translocation
T5623	48-58	NNP	denotes	Importin-α
T5624	59-68	VBZ	denotes	regulates
T5625	69-72	DT	denotes	the
T5626	73-80	JJ	denotes	nuclear
T5627	81-87	NN	denotes	import
T5628	88-90	IN	denotes	of
T5629	91-96	NNP	denotes	NF-κB
T5630	97-100	NNP	denotes	Rel
T5631	101-111	CD	denotes	subunits23
T5632	111-112	,	denotes	,
T5633	113-115	CD	denotes	24
T5634	115-116	.	denotes	.
T5635	117-121	CD	denotes	RPS3
T5636	122-129	NNS	denotes	harbors
T5637	130-131	DT	denotes	a
T5638	132-139	JJ	denotes	nuclear
T5639	140-152	NN	denotes	localization
T5640	153-159	NN	denotes	signal
T5641	160-161	-LRB-	denotes	(
T5642	161-164	NNP	denotes	NLS
T5643	164-165	-RRB-	denotes	)
T5644	166-174	NN	denotes	sequence
T5645	175-178	CC	denotes	and
T5646	179-182	PRP$	denotes	its
T5647	183-190	JJ	denotes	nuclear
T5648	191-204	NN	denotes	translocation
T5649	205-211	VBZ	denotes	occurs
T5650	212-214	IN	denotes	in
T5651	215-223	NN	denotes	parallel
T5652	224-226	TO	denotes	to
T5653	226-227	,	denotes	,
T5654	228-231	CC	denotes	but
T5655	232-245	RB	denotes	independently
T5656	246-248	IN	denotes	of
T5657	248-249	,	denotes	,
T5658	250-253	CD	denotes	p65
T5659	254-268	NNS	denotes	translocation6
T5660	268-269	.	denotes	.
T5661	270-272	PRP	denotes	We
T5662	273-283	VBD	denotes	envisioned
T5663	284-288	IN	denotes	that
T5664	289-293	NNP	denotes	RPS3
T5665	294-299	MD	denotes	could
T5666	300-304	RB	denotes	also
T5667	305-312	VB	denotes	utilize
T5668	313-316	DT	denotes	the
T5669	317-327	JJ	denotes	importin-α
T5670	327-328	NN	denotes	/
T5671	328-329	NN	denotes	β
T5672	330-337	NN	denotes	pathway
T5673	337-338	.	denotes	.
T5674	339-349	JJ	denotes	Consistent
T5675	350-354	IN	denotes	with
T5676	355-359	DT	denotes	this
T5677	360-366	NN	denotes	notion
T5678	366-367	,	denotes	,
T5679	368-372	JJ	denotes	RPS3
T5680	373-384	NN	denotes	association
T5681	385-389	IN	denotes	with
T5682	390-400	JJ	denotes	importin-α
T5683	400-401	,	denotes	,
T5684	402-405	CC	denotes	but
T5685	406-409	RB	denotes	not
T5686	410-420	JJ	denotes	importin-β
T5687	420-421	,	denotes	,
T5688	422-425	VBD	denotes	was
T5689	426-434	VBN	denotes	enhanced
T5690	435-437	IN	denotes	in
T5691	438-441	NNP	denotes	TNF
T5692	442-452	VBD	denotes	stimulated
T5693	453-458	NNS	denotes	cells
T5694	459-460	-LRB-	denotes	(
T5695	460-464	NNP	denotes	Fig.
T5696	465-467	CD	denotes	3a
T5697	467-468	-RRB-	denotes	)
T5698	468-469	.	denotes	.
T5699	470-479	RB	denotes	Therefore
T5700	479-480	,	denotes	,
T5701	481-483	PRP	denotes	we
T5702	484-492	VBD	denotes	examined
T5703	493-500	IN	denotes	whether
T5704	501-505	NNP	denotes	RPS3
T5705	506-513	JJ	denotes	binding
T5706	514-516	TO	denotes	to
T5707	517-527	NN	denotes	importin-α
T5708	528-530	VBZ	denotes	is
T5709	531-540	JJ	denotes	essential
T5710	541-544	IN	denotes	for
T5711	545-552	JJ	denotes	nuclear
T5712	553-566	NN	denotes	translocation
T5713	567-573	IN	denotes	during
T5714	574-579	NNP	denotes	NF-κB
T5715	580-590	NN	denotes	activation
T5716	590-591	.	denotes	.
T5717	592-597	IN	denotes	Since
T5718	598-602	NNP	denotes	IκBα
T5719	603-614	NN	denotes	degradation
T5720	615-617	VBZ	denotes	is
T5721	618-619	DT	denotes	a
T5722	620-632	NN	denotes	prerequisite
T5723	633-635	TO	denotes	to
T5724	636-642	VB	denotes	unmask
T5725	643-646	DT	denotes	the
T5726	647-650	NNP	denotes	NLS
T5727	651-653	IN	denotes	of
T5728	654-657	CD	denotes	p65
T5729	657-658	,	denotes	,
T5730	659-662	CC	denotes	and
T5731	663-667	DT	denotes	both
T5732	668-672	CD	denotes	RPS3
T5733	673-676	CC	denotes	and
T5734	677-681	NNP	denotes	IκBα
T5735	682-686	NN	denotes	bind
T5736	687-689	TO	denotes	to
T5737	690-693	VB	denotes	p65
T5738	694-696	IN	denotes	in
T5739	697-700	DT	denotes	the
T5740	701-712	JJ	denotes	cytoplasmic
T5741	713-723	NN	denotes	inhibitory
T5742	724-731	NN	denotes	complex
T5743	731-732	,	denotes	,
T5744	733-735	PRP	denotes	we
T5745	736-742	VBD	denotes	tested
T5746	743-750	IN	denotes	whether
T5747	751-755	NNP	denotes	IκBα
T5748	756-767	NN	denotes	degradation
T5749	768-770	VBZ	denotes	is
T5750	771-779	VBN	denotes	required
T5751	780-783	IN	denotes	for
T5752	784-787	DT	denotes	the
T5753	788-798	NN	denotes	liberation
T5754	799-801	IN	denotes	of
T5755	802-806	NNP	denotes	RPS3
T5756	806-807	.	denotes	.
T5757	808-810	PRP	denotes	We
T5758	811-819	VBD	denotes	measured
T5759	820-823	DT	denotes	the
T5760	824-835	NN	denotes	association
T5761	836-838	IN	denotes	of
T5762	839-843	CD	denotes	RPS3
T5763	844-848	IN	denotes	with
T5764	849-859	JJ	denotes	importin-α
T5765	860-862	IN	denotes	in
T5766	863-867	JJ	denotes	293T
T5767	868-873	NNS	denotes	cells
T5768	874-888	VBG	denotes	overexpressing
T5769	889-898	JJ	denotes	wild-type
T5770	899-903	NNP	denotes	IκBα
T5771	904-906	CC	denotes	or
T5772	907-909	DT	denotes	an
T5773	910-914	NNP	denotes	IκBα
T5774	915-921	JJ	denotes	mutant
T5775	922-923	-LRB-	denotes	(
T5776	923-927	NNP	denotes	SSAA
T5777	927-928	-RRB-	denotes	)
T5778	929-938	NN	denotes	resistant
T5779	939-941	TO	denotes	to
T5780	942-954	JJ	denotes	IKKβ-induced
T5781	955-970	NN	denotes	phosphorylation
T5782	971-974	CC	denotes	and
T5783	975-986	NN	denotes	degradation
T5784	986-987	.	denotes	.
T5785	988-990	IN	denotes	In
T5786	991-996	NNS	denotes	cells
T5787	997-1008	VBN	denotes	transfected
T5788	1009-1013	IN	denotes	with
T5789	1014-1023	JJ	denotes	wild-type
T5790	1024-1028	NNP	denotes	IκBα
T5791	1028-1029	,	denotes	,
T5792	1030-1033	NNP	denotes	TNF
T5793	1034-1045	NN	denotes	stimulation
T5794	1046-1055	VBD	denotes	augmented
T5795	1056-1059	DT	denotes	the
T5796	1060-1071	NN	denotes	interaction
T5797	1072-1074	IN	denotes	of
T5798	1075-1079	NNP	denotes	RPS3
T5799	1080-1083	CC	denotes	and
T5800	1084-1094	JJ	denotes	importin-α
T5801	1095-1097	TO	denotes	to
T5802	1098-1099	DT	denotes	a
T5803	1100-1107	JJ	denotes	similar
T5804	1108-1114	NN	denotes	degree
T5805	1115-1117	IN	denotes	as
T5806	1118-1120	IN	denotes	in
T5807	1121-1136	JJ	denotes	non-transfected
T5808	1137-1142	NNS	denotes	cells
T5809	1142-1143	.	denotes	.
T5810	1144-1146	IN	denotes	By
T5811	1147-1155	NN	denotes	contrast
T5812	1155-1156	,	denotes	,
T5813	1157-1159	PRP	denotes	we
T5814	1160-1168	VBD	denotes	observed
T5815	1169-1173	IN	denotes	that
T5816	1174-1177	DT	denotes	the
T5817	1178-1193	JJ	denotes	RPS3-importin-α
T5818	1194-1205	NN	denotes	association
T5819	1206-1209	VBD	denotes	was
T5820	1210-1219	VBN	denotes	abolished
T5821	1220-1222	IN	denotes	by
T5822	1223-1226	DT	denotes	the
T5823	1227-1235	NN	denotes	presence
T5824	1236-1238	IN	denotes	of
T5825	1239-1253	JJ	denotes	non-degradable
T5826	1254-1258	NNP	denotes	IκBα
T5827	1259-1260	-LRB-	denotes	(
T5828	1260-1264	NNP	denotes	Fig.
T5829	1265-1267	CD	denotes	3b
T5830	1267-1268	-RRB-	denotes	)
T5831	1268-1269	.	denotes	.
T5832	1270-1272	TO	denotes	To
T5833	1273-1280	VB	denotes	examine
T5834	1281-1288	IN	denotes	whether
T5835	1289-1293	NNP	denotes	IκBα
T5836	1294-1296	VBZ	denotes	is
T5837	1297-1300	DT	denotes	the
T5838	1301-1305	JJ	denotes	only
T5839	1306-1317	JJ	denotes	cytoplasmic
T5840	1318-1325	NN	denotes	barrier
T5841	1326-1336	VBG	denotes	precluding
T5842	1337-1341	NNP	denotes	RPS3
T5843	1342-1349	JJ	denotes	nuclear
T5844	1350-1363	NN	denotes	translocation
T5845	1363-1364	,	denotes	,
T5846	1365-1367	PRP	denotes	we
T5847	1368-1376	VBD	denotes	measured
T5848	1377-1381	DT	denotes	both
T5849	1382-1397	JJ	denotes	RPS3-importin-α
T5850	1398-1409	NN	denotes	association
T5851	1410-1413	CC	denotes	and
T5852	1414-1421	JJ	denotes	nuclear
T5853	1422-1426	NN	denotes	RPS3
T5854	1427-1432	IN	denotes	after
T5855	1433-1441	VBG	denotes	reducing
T5856	1442-1446	NNP	denotes	IκBα
T5857	1447-1457	NN	denotes	expression
T5858	1457-1458	.	denotes	.
T5859	1459-1467	VBN	denotes	Compared
T5860	1468-1472	IN	denotes	with
T5861	1473-1484	JJ	denotes	nonspecific
T5862	1485-1490	NNP	denotes	siRNA
T5863	1490-1491	,	denotes	,
T5864	1492-1497	NNP	denotes	siRNA
T5865	1498-1507	VBG	denotes	targeting
T5866	1508-1510	IN	denotes	of
T5867	1511-1515	NNP	denotes	IκBα
T5868	1516-1526	RB	denotes	completely
T5869	1527-1535	VBD	denotes	depleted
T5870	1536-1540	NNP	denotes	IκBα
T5871	1541-1543	IN	denotes	in
T5872	1544-1550	NNP	denotes	Jurkat
T5873	1551-1556	NNS	denotes	cells
T5874	1557-1558	-LRB-	denotes	(
T5875	1558-1562	NNP	denotes	Fig.
T5876	1563-1565	CD	denotes	3c
T5877	1565-1566	,	denotes	,
T5878	1567-1572	NN	denotes	input
T5879	1572-1573	-RRB-	denotes	)
T5880	1573-1574	.	denotes	.
T5881	1575-1587	RB	denotes	Nevertheless
T5882	1587-1588	,	denotes	,
T5883	1589-1592	DT	denotes	the
T5884	1593-1608	JJ	denotes	RPS3-importin-α
T5885	1609-1620	NN	denotes	association
T5886	1621-1624	VBD	denotes	was
T5887	1625-1628	RB	denotes	not
T5888	1629-1638	VBN	denotes	augmented
T5889	1639-1640	-LRB-	denotes	(
T5890	1640-1644	NNP	denotes	Fig.
T5891	1645-1647	CD	denotes	3c
T5892	1647-1648	-RRB-	denotes	)
T5893	1648-1649	,	denotes	,
T5894	1650-1653	CC	denotes	nor
T5895	1654-1657	VBD	denotes	was
T5896	1658-1669	JJ	denotes	significant
T5897	1670-1677	JJ	denotes	nuclear
T5898	1678-1682	JJ	denotes	RPS3
T5899	1683-1691	VBN	denotes	detected
T5900	1692-1693	-LRB-	denotes	(
T5901	1693-1697	NNP	denotes	Fig.
T5902	1698-1700	CD	denotes	3d
T5903	1700-1701	-RRB-	denotes	)
T5904	1701-1702	.	denotes	.
T5905	1703-1711	RB	denotes	Moreover
T5906	1711-1712	,	denotes	,
T5907	1713-1718	NNS	denotes	cells
T5908	1719-1726	VBN	denotes	treated
T5909	1727-1731	IN	denotes	with
T5910	1732-1738	NN	denotes	sodium
T5911	1739-1750	NN	denotes	pervanadate
T5912	1751-1752	-LRB-	denotes	(
T5913	1752-1754	NNP	denotes	Pv
T5914	1754-1755	-RRB-	denotes	)
T5915	1756-1758	TO	denotes	to
T5916	1759-1765	VB	denotes	induce
T5917	1766-1770	NNP	denotes	IκBα
T5918	1771-1782	NN	denotes	degradation
T5919	1783-1790	IN	denotes	through
T5920	1791-1793	DT	denotes	an
T5921	1794-1809	JJ	denotes	IKK-independent
T5922	1810-1824	NN	denotes	mechanism25-27
T5923	1825-1828	VBD	denotes	did
T5924	1829-1832	RB	denotes	not
T5925	1833-1837	VB	denotes	show
T5926	1838-1847	JJ	denotes	increased
T5927	1848-1859	NN	denotes	association
T5928	1860-1867	IN	denotes	between
T5929	1868-1872	CD	denotes	RPS3
T5930	1873-1876	CC	denotes	and
T5931	1877-1887	JJ	denotes	importin-α
T5932	1888-1889	-LRB-	denotes	(
T5933	1889-1893	NNP	denotes	Fig.
T5934	1894-1896	CD	denotes	3e
T5935	1897-1900	CC	denotes	and
T5936	1901-1914	NNP	denotes	Supplementary
T5937	1915-1919	NNP	denotes	Fig.
T5938	1920-1922	CD	denotes	3b
T5939	1922-1923	-RRB-	denotes	)
T5940	1924-1926	CC	denotes	or
T5941	1927-1934	JJ	denotes	nuclear
T5942	1935-1947	NN	denotes	accumulation
T5943	1948-1950	IN	denotes	of
T5944	1951-1955	NNP	denotes	RPS3
T5945	1955-1956	,	denotes	,
T5946	1957-1964	IN	denotes	despite
T5947	1965-1973	JJ	denotes	complete
T5948	1974-1978	NNP	denotes	IκBα
T5949	1979-1990	NN	denotes	degradation
T5950	1991-1992	-LRB-	denotes	(
T5951	1992-2005	NNP	denotes	Supplementary
T5952	2006-2010	NNP	denotes	Fig.
T5953	2011-2013	CD	denotes	3c
T5954	2013-2014	-RRB-	denotes	)
T5955	2014-2015	.	denotes	.
T5956	2016-2018	PRP	denotes	We
T5957	2019-2026	RB	denotes	further
T5958	2027-2035	VBD	denotes	examined
T5959	2036-2043	IN	denotes	whether
T5960	2044-2045	DT	denotes	a
T5961	2046-2056	JJ	denotes	subsequent
T5962	2057-2062	NN	denotes	NF-κB
T5963	2063-2073	NN	denotes	activation
T5964	2074-2080	NN	denotes	signal
T5965	2081-2094	RB	denotes	independently
T5966	2095-2103	VBZ	denotes	promotes
T5967	2104-2107	DT	denotes	the
T5968	2108-2118	JJ	denotes	importin-α
T5969	2119-2130	NN	denotes	association
T5970	2131-2134	CC	denotes	and
T5971	2135-2142	JJ	denotes	nuclear
T5972	2143-2152	NN	denotes	transport
T5973	2153-2155	IN	denotes	of
T5974	2156-2160	CD	denotes	RPS3
T5975	2161-2166	IN	denotes	after
T5976	2167-2171	NNP	denotes	IκBα
T5977	2172-2183	NN	denotes	degradation
T5978	2183-2184	.	denotes	.
T5979	2185-2187	PRP	denotes	We
T5980	2188-2193	VBD	denotes	found
T5981	2194-2198	IN	denotes	that
T5982	2199-2202	NNP	denotes	TNF
T5983	2203-2214	NN	denotes	stimulation
T5984	2215-2224	VBG	denotes	following
T5985	2225-2227	NNP	denotes	Pv
T5986	2228-2237	NN	denotes	treatment
T5987	2238-2241	VBD	denotes	was
T5988	2242-2250	VBN	denotes	required
T5989	2251-2254	IN	denotes	for
T5990	2255-2258	DT	denotes	the
T5991	2259-2274	JJ	denotes	RPS3-importin-α
T5992	2275-2286	NN	denotes	association
T5993	2286-2287	,	denotes	,
T5994	2288-2298	JJ	denotes	comparable
T5995	2299-2301	TO	denotes	to
T5996	2302-2305	NNP	denotes	TNF
T5997	2306-2317	NN	denotes	stimulation
T5998	2318-2323	RB	denotes	alone
T5999	2324-2325	-LRB-	denotes	(
T6000	2325-2329	NNP	denotes	Fig.
T6001	2330-2332	CD	denotes	3e
T6002	2332-2333	-RRB-	denotes	)
T6003	2333-2334	.	denotes	.
T6004	2335-2339	RB	denotes	Thus
T6005	2339-2340	,	denotes	,
T6006	2341-2345	NNP	denotes	IκBα
T6007	2346-2361	NN	denotes	phosphorylation
T6008	2362-2365	CC	denotes	and
T6009	2366-2377	NN	denotes	degradation
T6010	2378-2384	PRP	denotes	itself
T6011	2385-2387	VBZ	denotes	is
T6012	2388-2396	VBN	denotes	required
T6013	2397-2400	CC	denotes	but
T6014	2401-2404	RB	denotes	not
T6015	2405-2415	JJ	denotes	sufficient
T6016	2416-2418	TO	denotes	to
T6017	2419-2424	VB	denotes	cause
T6018	2425-2429	JJ	denotes	RPS3
T6019	2430-2441	NN	denotes	association
T6020	2442-2446	IN	denotes	with
T6021	2447-2457	JJ	denotes	importin-α
T6022	2458-2466	VBN	denotes	followed
T6023	2467-2469	IN	denotes	by
T6024	2470-2477	JJ	denotes	nuclear
T6025	2478-2491	NN	denotes	translocation
T6026	2491-2492	.	denotes	.
T6027	2493-2499	RB	denotes	Rather
T6028	2499-2500	,	denotes	,
T6029	2501-2503	DT	denotes	an
T6030	2504-2514	JJ	denotes	additional
T6031	2515-2521	NN	denotes	signal
T6032	2521-2522	,	denotes	,
T6033	2523-2534	RB	denotes	potentially
T6034	2535-2539	NNP	denotes	IKKβ
T6035	2540-2555	NN	denotes	phosphorylation
T6036	2556-2558	IN	denotes	of
T6037	2559-2563	NNP	denotes	RPS3
T6038	2563-2564	,	denotes	,
T6039	2565-2567	VBZ	denotes	is
T6040	2568-2576	VBN	denotes	required
T6041	2576-2577	.	denotes	.
R4496	T5617	T5618	compound	IκBα,degradation
R4497	T5618	T5624	nsubj	degradation,regulates
R4498	T5619	T5618	cc	and,degradation
R4499	T5620	T5622	amod	RPS3,translocation
R4500	T5621	T5622	amod	nuclear,translocation
R4501	T5622	T5623	compound	translocation,Importin-α
R4502	T5623	T5624	nsubj	Importin-α,regulates
R4503	T5624	T5624	ROOT	regulates,regulates
R4504	T5625	T5627	det	the,import
R4505	T5626	T5627	amod	nuclear,import
R4506	T5627	T5624	dobj	import,regulates
R4507	T5628	T5627	prep	of,import
R4508	T5629	T5630	compound	NF-κB,Rel
R4509	T5630	T5628	pobj	Rel,of
R4510	T5631	T5630	appos	subunits23,Rel
R4511	T5632	T5630	punct	",",Rel
R4512	T5633	T5630	appos	24,Rel
R4513	T5634	T5624	punct	.,regulates
R4514	T5635	T5636	nummod	RPS3,harbors
R4515	T5636	T5649	dep	harbors,occurs
R4516	T5637	T5640	det	a,signal
R4517	T5638	T5639	amod	nuclear,localization
R4518	T5639	T5640	compound	localization,signal
R4519	T5640	T5636	dobj	signal,harbors
R4520	T5641	T5642	punct	(,NLS
R4521	T5642	T5640	appos	NLS,signal
R4522	T5643	T5642	punct	),NLS
R4523	T5644	T5640	conj	sequence,signal
R4524	T5645	T5644	cc	and,sequence
R4525	T5646	T5648	poss	its,translocation
R4526	T5647	T5648	amod	nuclear,translocation
R4527	T5648	T5649	nsubj	translocation,occurs
R4528	T5649	T5649	ROOT	occurs,occurs
R4529	T5650	T5649	prep	in,occurs
R4530	T5651	T5650	pobj	parallel,in
R4531	T5652	T5651	prep	to,parallel
R4532	T5653	T5649	punct	",",occurs
R4533	T5654	T5649	cc	but,occurs
R4534	T5655	T5656	advmod	independently,of
R4535	T5656	T5649	conj	of,occurs
R4536	T5657	T5656	punct	",",of
R4537	T5658	T5659	nummod	p65,translocation6
R4538	T5659	T5656	pobj	translocation6,of
R4539	T5660	T5649	punct	.,occurs
R4540	T5661	T5662	nsubj	We,envisioned
R4541	T5662	T5662	ROOT	envisioned,envisioned
R4542	T5663	T5667	mark	that,utilize
R4543	T5664	T5667	nsubj	RPS3,utilize
R4544	T5665	T5667	aux	could,utilize
R4545	T5666	T5667	advmod	also,utilize
R4546	T5667	T5662	ccomp	utilize,envisioned
R4547	T5668	T5672	det	the,pathway
R4548	T5669	T5672	amod	importin-α,pathway
R4549	T5670	T5672	nmod	/,pathway
R4550	T5671	T5672	compound	β,pathway
R4551	T5672	T5667	dobj	pathway,utilize
R4552	T5673	T5662	punct	.,envisioned
R4553	T5674	T5689	advmod	Consistent,enhanced
R4554	T5675	T5674	prep	with,Consistent
R4555	T5676	T5677	det	this,notion
R4556	T5677	T5675	pobj	notion,with
R4557	T5678	T5689	punct	",",enhanced
R4558	T5679	T5680	amod	RPS3,association
R4559	T5680	T5689	nsubjpass	association,enhanced
R4560	T5681	T5680	prep	with,association
R4561	T5682	T5681	pobj	importin-α,with
R4562	T5683	T5680	punct	",",association
R4563	T5684	T5680	cc	but,association
R4564	T5685	T5686	neg	not,importin-β
R4565	T5686	T5680	conj	importin-β,association
R4566	T5687	T5689	punct	",",enhanced
R4567	T5688	T5689	auxpass	was,enhanced
R4568	T5689	T5689	ROOT	enhanced,enhanced
R4569	T5690	T5689	prep	in,enhanced
R4570	T5691	T5690	pobj	TNF,in
R4584	T5705	T5702	ccomp	binding,examined
R4585	T5706	T5707	aux	to,importin-α
R4586	T5707	T5705	xcomp	importin-α,binding
R4587	T5708	T5708	ROOT	is,is
R4588	T5709	T5708	acomp	essential,is
R4589	T5710	T5708	prep	for,is
R4590	T5711	T5712	amod	nuclear,translocation
R4591	T5712	T5710	pobj	translocation,for
R4592	T5713	T5712	prep	during,translocation
R4593	T5714	T5715	compound	NF-κB,activation
R4594	T5715	T5713	pobj	activation,during
R4595	T5716	T5708	punct	.,is
R4596	T5717	T5720	mark	Since,is
R4597	T5718	T5719	compound	IκBα,degradation
R4598	T5719	T5720	nsubj	degradation,is
R4599	T5720	T5720	ROOT	is,is
R4600	T5721	T5722	det	a,prerequisite
R4601	T5722	T5720	attr	prerequisite,is
R4602	T5723	T5724	aux	to,unmask
R4603	T5724	T5722	acl	unmask,prerequisite
R4604	T5725	T5726	det	the,NLS
R4605	T5726	T5724	dobj	NLS,unmask
R4606	T5727	T5726	prep	of,NLS
R4607	T5728	T5727	pobj	p65,of
R4608	T5729	T5720	punct	",",is
R4609	T5730	T5720	cc	and,is
R4610	T5731	T5732	det	both,RPS3
R4611	T5732	T5737	dep	RPS3,p65
R4612	T5733	T5732	cc	and,RPS3
R4613	T5734	T5735	compound	IκBα,bind
R4614	T5735	T5732	conj	bind,RPS3
R4615	T5736	T5737	aux	to,p65
R4616	T5737	T5745	advcl	p65,tested
R4617	T5738	T5737	prep	in,p65
R4618	T5739	T5742	det	the,complex
R4619	T5740	T5742	amod	cytoplasmic,complex
R4620	T5741	T5742	compound	inhibitory,complex
R4621	T5742	T5738	pobj	complex,in
R4622	T5743	T5745	punct	",",tested
R4623	T5744	T5745	nsubj	we,tested
R4624	T5745	T5720	conj	tested,is
R4625	T5746	T5750	mark	whether,required
R4626	T5747	T5748	compound	IκBα,degradation
R4627	T5748	T5750	nsubjpass	degradation,required
R4628	T5749	T5750	auxpass	is,required
R4629	T5750	T5745	ccomp	required,tested
R4630	T5751	T5750	prep	for,required
R4631	T5752	T5753	det	the,liberation
R4632	T5753	T5751	pobj	liberation,for
R4633	T5754	T5753	prep	of,liberation
R4634	T5755	T5754	pobj	RPS3,of
R4635	T5756	T5745	punct	.,tested
R4650	T5771	T5770	cc	or,IκBα
R4651	T5772	T5774	det	an,mutant
R4652	T5773	T5774	compound	IκBα,mutant
R4653	T5774	T5770	conj	mutant,IκBα
R4654	T5775	T5776	punct	(,SSAA
R4655	T5776	T5774	appos	SSAA,mutant
R4656	T5777	T5774	punct	),mutant
R4657	T5778	T5768	conj	resistant,overexpressing
R4658	T5779	T5778	prep	to,resistant
R4659	T5780	T5781	advmod	IKKβ-induced,phosphorylation
R4660	T5781	T5779	pobj	phosphorylation,to
R4661	T5782	T5781	cc	and,phosphorylation
R4662	T5783	T5781	conj	degradation,phosphorylation
R4663	T5784	T5758	punct	.,measured
R4664	T5785	T5794	prep	In,augmented
R4665	T5786	T5785	pobj	cells,In
R4666	T5787	T5786	acl	transfected,cells
R4667	T5788	T5787	prep	with,transfected
R4668	T5789	T5790	compound	wild-type,IκBα
R4669	T5790	T5788	pobj	IκBα,with
R4670	T5791	T5794	punct	",",augmented
R4671	T5792	T5793	compound	TNF,stimulation
R4672	T5793	T5794	nsubj	stimulation,augmented
R4673	T5794	T5794	ROOT	augmented,augmented
R4674	T5795	T5796	det	the,interaction
R4675	T5796	T5794	dobj	interaction,augmented
R4676	T5797	T5796	prep	of,interaction
R4677	T5798	T5797	pobj	RPS3,of
R4678	T5799	T5798	cc	and,RPS3
R4679	T5800	T5794	oprd	importin-α,augmented
R4680	T5801	T5794	prep	to,augmented
R4681	T5802	T5804	det	a,degree
R4682	T5803	T5804	amod	similar,degree
R4683	T5804	T5801	pobj	degree,to
R4684	T5805	T5804	prep	as,degree
R4685	T5806	T5805	prep	in,as
R4686	T5807	T5808	amod	non-transfected,cells
R4687	T5808	T5806	pobj	cells,in
R4688	T5809	T5794	punct	.,augmented
R4689	T5810	T5814	prep	By,observed
R4690	T5811	T5810	pobj	contrast,By
R4691	T5812	T5814	punct	",",observed
R4692	T5813	T5814	nsubj	we,observed
R4693	T5814	T5814	ROOT	observed,observed
R4694	T5815	T5820	mark	that,abolished
R4695	T5816	T5818	det	the,association
R4696	T5817	T5818	amod	RPS3-importin-α,association
R4697	T5818	T5820	nsubjpass	association,abolished
R4698	T5819	T5820	auxpass	was,abolished
R4699	T5820	T5814	ccomp	abolished,observed
R4700	T5821	T5820	agent	by,abolished
R4701	T5822	T5823	det	the,presence
R4702	T5823	T5821	pobj	presence,by
R4703	T5824	T5823	prep	of,presence
R4704	T5825	T5826	compound	non-degradable,IκBα
R4705	T5826	T5824	pobj	IκBα,of
R4706	T5827	T5830	punct	(,)
R4707	T5828	T5830	nmod	Fig.,)
R4708	T5829	T5828	nummod	3b,Fig.
R4709	T5830	T5820	punct	),abolished
R4710	T5831	T5814	punct	.,observed
R4711	T5832	T5833	aux	To,examine
R4712	T5833	T5836	csubj	examine,is
R4713	T5834	T5836	mark	whether,is
R4714	T5835	T5836	nsubj	IκBα,is
R4715	T5836	T5847	advcl	is,measured
R4716	T5837	T5840	det	the,barrier
R4717	T5838	T5840	amod	only,barrier
R4718	T5839	T5840	amod	cytoplasmic,barrier
R4719	T5840	T5836	attr	barrier,is
R4720	T5841	T5840	acl	precluding,barrier
R4721	T5842	T5844	nmod	RPS3,translocation
R4722	T5843	T5844	amod	nuclear,translocation
R4723	T5844	T5841	dobj	translocation,precluding
R4724	T5845	T5847	punct	",",measured
R4725	T5846	T5847	nsubj	we,measured
R4726	T5847	T5847	ROOT	measured,measured
R4727	T5848	T5850	preconj	both,association
R4728	T5849	T5850	compound	RPS3-importin-α,association
R4729	T5850	T5847	dobj	association,measured
R4730	T5851	T5850	cc	and,association
R4731	T5852	T5853	amod	nuclear,RPS3
R4732	T5853	T5850	conj	RPS3,association
R4733	T5854	T5847	prep	after,measured
R4734	T5855	T5854	pcomp	reducing,after
R4735	T5856	T5857	compound	IκBα,expression
R4736	T5857	T5855	dobj	expression,reducing
R4737	T5858	T5847	punct	.,measured
R4738	T5859	T5865	amod	Compared,targeting
R4739	T5860	T5859	prep	with,Compared
R4740	T5861	T5862	compound	nonspecific,siRNA
R4741	T5862	T5860	pobj	siRNA,with
R4742	T5863	T5862	punct	",",siRNA
R4743	T5864	T5865	compound	siRNA,targeting
R4744	T5865	T5869	nsubj	targeting,depleted
R4745	T5866	T5865	prep	of,targeting
R4746	T5867	T5866	pobj	IκBα,of
R4747	T5868	T5869	advmod	completely,depleted
R4748	T5869	T5869	ROOT	depleted,depleted
R4749	T5870	T5869	dobj	IκBα,depleted
R4750	T5871	T5869	prep	in,depleted
R4751	T5872	T5873	compound	Jurkat,cells
R4752	T5873	T5871	pobj	cells,in
R4753	T5874	T5878	punct	(,input
R4754	T5875	T5876	compound	Fig.,3c
R4755	T5876	T5878	nummod	3c,input
R4756	T5877	T5878	punct	",",input
R4757	T5878	T5869	parataxis	input,depleted
R4758	T5879	T5878	punct	),input
R4759	T5880	T5869	punct	.,depleted
R4760	T5881	T5888	advmod	Nevertheless,augmented
R4761	T5882	T5888	punct	",",augmented
R4762	T5883	T5885	det	the,association
R4763	T5884	T5885	amod	RPS3-importin-α,association
R4764	T5885	T5888	nsubjpass	association,augmented
R4765	T5886	T5888	auxpass	was,augmented
R4766	T5887	T5888	neg	not,augmented
R4767	T5888	T5888	ROOT	augmented,augmented
R4768	T5889	T5888	punct	(,augmented
R4769	T5890	T5888	dobj	Fig.,augmented
R4770	T5891	T5890	nummod	3c,Fig.
R4771	T5892	T5888	punct	),augmented
R4772	T5893	T5888	punct	",",augmented
R4773	T5894	T5888	cc	nor,augmented
R4774	T5895	T5899	auxpass	was,detected
R4775	T5896	T5899	amod	significant,detected
R4776	T5897	T5898	amod	nuclear,RPS3
R4777	T5898	T5899	amod	RPS3,detected
R4778	T5899	T5888	conj	detected,augmented
R4779	T5900	T5899	punct	(,detected
R4780	T5901	T5902	compound	Fig.,3d
R4781	T5902	T5899	appos	3d,detected
R4782	T5903	T5899	punct	),detected
R4783	T5904	T5888	punct	.,augmented
R4784	T5905	T5925	advmod	Moreover,show
R4785	T5906	T5925	punct	",",show
R4786	T5907	T5925	nsubj	cells,show
R4787	T5908	T5907	acl	treated,cells
R4788	T5909	T5908	prep	with,treated
R4789	T5910	T5911	compound	sodium,pervanadate
R4790	T5911	T5909	pobj	pervanadate,with
R4791	T5912	T5913	punct	(,Pv
R4792	T5913	T5911	appos	Pv,pervanadate
R4793	T5914	T5908	punct	),treated
R4794	T5915	T5916	aux	to,induce
R4795	T5916	T5908	advcl	induce,treated
R4796	T5917	T5918	compound	IκBα,degradation
R4797	T5918	T5916	dobj	degradation,induce
R4798	T5919	T5916	prep	through,induce
R4799	T5920	T5922	det	an,mechanism25-27
R4800	T5921	T5922	amod	IKK-independent,mechanism25-27
R4801	T5922	T5919	pobj	mechanism25-27,through
R4802	T5923	T5925	aux	did,show
R4803	T5924	T5925	neg	not,show
R4804	T5925	T5925	ROOT	show,show
R4805	T5926	T5927	amod	increased,association
R4806	T5927	T5925	dobj	association,show
R4807	T5928	T5927	prep	between,association
R4808	T5929	T5928	pobj	RPS3,between
R4809	T5930	T5929	cc	and,RPS3
R4810	T5931	T5929	conj	importin-α,RPS3
R4811	T5932	T5927	punct	(,association
R4812	T5933	T5927	appos	Fig.,association
R4813	T5934	T5933	nummod	3e,Fig.
R4814	T5935	T5933	cc	and,Fig.
R4815	T5936	T5937	compound	Supplementary,Fig.
R4816	T5937	T5933	conj	Fig.,Fig.
R4817	T5938	T5937	nummod	3b,Fig.
R4818	T5939	T5937	punct	),Fig.
R4819	T5940	T5933	cc	or,Fig.
R4820	T5941	T5942	amod	nuclear,accumulation
R4821	T5942	T5933	conj	accumulation,Fig.
R4822	T5943	T5942	prep	of,accumulation
R4823	T5944	T5943	pobj	RPS3,of
R4824	T5945	T5942	punct	",",accumulation
R4825	T5946	T5925	prep	despite,show
R4826	T5947	T5949	amod	complete,degradation
R4827	T5948	T5949	compound	IκBα,degradation
R4828	T5949	T5946	pobj	degradation,despite
R4829	T5950	T5952	punct	(,Fig.
R4830	T5951	T5952	compound	Supplementary,Fig.
R4831	T5952	T5949	appos	Fig.,degradation
R4832	T5953	T5952	nummod	3c,Fig.
R4833	T5954	T5952	punct	),Fig.
R4834	T5955	T5925	punct	.,show
R4835	T5956	T5958	nsubj	We,examined
R4836	T5957	T5958	advmod	further,examined
R4837	T5958	T5958	ROOT	examined,examined
R4838	T5959	T5966	mark	whether,promotes
R4839	T5960	T5964	det	a,signal
R4840	T5961	T5964	amod	subsequent,signal
R4841	T5962	T5964	compound	NF-κB,signal
R4842	T5963	T5964	compound	activation,signal
R4843	T5964	T5966	nsubj	signal,promotes
R4844	T5965	T5966	advmod	independently,promotes
R4845	T5966	T5958	ccomp	promotes,examined
R4846	T5967	T5969	det	the,association
R4847	T5968	T5969	amod	importin-α,association
R4848	T5969	T5966	dobj	association,promotes
R4849	T5970	T5969	cc	and,association
R4850	T5971	T5972	amod	nuclear,transport
R4851	T5972	T5969	conj	transport,association
R4852	T5973	T5972	prep	of,transport
R4853	T5974	T5973	pobj	RPS3,of
R4854	T5975	T5969	prep	after,association
R4855	T5976	T5977	compound	IκBα,degradation
R4856	T5977	T5975	pobj	degradation,after
R4857	T5978	T5958	punct	.,examined
R4858	T5979	T5980	nsubj	We,found
R4859	T5980	T5980	ROOT	found,found
R4860	T5981	T5988	mark	that,required
R4861	T5982	T5983	compound	TNF,stimulation
R4862	T5983	T5988	nsubjpass	stimulation,required
R4863	T5984	T5983	acl	following,stimulation
R4864	T5985	T5986	compound	Pv,treatment
R4865	T5986	T5984	pobj	treatment,following
R4866	T5987	T5988	auxpass	was,required
R4867	T5988	T5980	ccomp	required,found
R4868	T5989	T5988	prep	for,required
R4869	T5990	T5992	det	the,association
R4870	T5991	T5992	compound	RPS3-importin-α,association
R4871	T5992	T5989	pobj	association,for
R4872	T5993	T5992	punct	",",association
R4873	T5994	T5997	amod	comparable,stimulation
R4874	T5995	T5994	prep	to,comparable
R4875	T5996	T5995	pobj	TNF,to
R4876	T5997	T5988	dobj	stimulation,required
R4877	T5998	T5997	advmod	alone,stimulation
R4878	T5999	T5997	punct	(,stimulation
R4879	T6000	T5997	appos	Fig.,stimulation
R4880	T6001	T6000	nummod	3e,Fig.
R4881	T6002	T5997	punct	),stimulation
R4882	T6003	T5980	punct	.,found
R4883	T6004	T6012	advmod	Thus,required
R4884	T6005	T6012	punct	",",required
R4885	T6006	T6007	compound	IκBα,phosphorylation
R4886	T6007	T6012	nsubjpass	phosphorylation,required
R4887	T6008	T6007	cc	and,phosphorylation
R4888	T6009	T6007	conj	degradation,phosphorylation
R4889	T6010	T6009	appos	itself,degradation
R4890	T6011	T6012	auxpass	is,required
R4891	T6012	T6012	ROOT	required,required
R4892	T6013	T6012	cc	but,required
R4893	T6014	T6015	neg	not,sufficient
R4894	T6015	T6012	conj	sufficient,required
R4895	T6016	T6017	aux	to,cause
R4896	T6017	T6015	xcomp	cause,sufficient
R4897	T6018	T6019	amod	RPS3,association
R4898	T6019	T6017	dobj	association,cause
R4899	T6020	T6019	prep	with,association
R4900	T6021	T6022	amod	importin-α,followed
R4901	T6022	T6020	pcomp	followed,with
R4902	T6023	T6022	agent	by,followed
R4903	T6024	T6025	amod	nuclear,translocation
R4904	T6025	T6023	pobj	translocation,by
R4905	T6026	T6012	punct	.,required
R4906	T6027	T6040	advmod	Rather,required
R4907	T6028	T6040	punct	",",required
R4908	T6029	T6031	det	an,signal
R4909	T6030	T6031	amod	additional,signal
R4910	T6031	T6040	nsubjpass	signal,required
R4911	T6032	T6035	punct	",",phosphorylation
R4912	T6033	T6035	advmod	potentially,phosphorylation
R4913	T6034	T6035	compound	IKKβ,phosphorylation
R4914	T6035	T6031	appos	phosphorylation,signal
R4915	T6036	T6035	prep	of,phosphorylation
R4916	T6037	T6036	pobj	RPS3,of
R4917	T6038	T6040	punct	",",required
R4918	T6039	T6040	auxpass	is,required
R4919	T6040	T6040	ROOT	required,required
R4920	T6041	T6040	punct	.,required
R4571	T5692	T5689	conj	stimulated,enhanced
R4572	T5693	T5692	dobj	cells,stimulated
R4573	T5694	T5696	punct	(,3a
R4574	T5695	T5696	compound	Fig.,3a
R4575	T5696	T5693	appos	3a,cells
R4576	T5697	T5693	punct	),cells
R4577	T5698	T5689	punct	.,enhanced
R4578	T5699	T5702	advmod	Therefore,examined
R4579	T5700	T5702	punct	",",examined
R4580	T5701	T5702	nsubj	we,examined
R4581	T5702	T5702	ROOT	examined,examined
R4582	T5703	T5705	mark	whether,binding
R4583	T5704	T5705	nsubj	RPS3,binding
R4636	T5757	T5758	nsubj	We,measured
R4637	T5758	T5758	ROOT	measured,measured
R4638	T5759	T5760	det	the,association
R4639	T5760	T5758	dobj	association,measured
R4640	T5761	T5760	prep	of,association
R4641	T5762	T5761	pobj	RPS3,of
R4642	T5763	T5762	prep	with,RPS3
R4643	T5764	T5763	pobj	importin-α,with
R4644	T5765	T5764	prep	in,importin-α
R4645	T5766	T5767	amod	293T,cells
R4646	T5767	T5765	pobj	cells,in
R4647	T5768	T5758	advcl	overexpressing,measured
R4648	T5769	T5770	compound	wild-type,IκBα
R4649	T5770	T5768	dobj	IκBα,overexpressing

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T6175	5-16	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T6176	603-614	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T6177	756-767	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T6178	975-986	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T6179	1771-1782	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T6180	1979-1990	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T6181	2172-2183	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T6182	2366-2377	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T6183	73-87	http://purl.obolibrary.org/obo/GO_0051170	denotes	nuclear import
T6184	140-152	http://purl.obolibrary.org/obo/GO_0051179	denotes	localization
T6185	153-159	http://purl.obolibrary.org/obo/GO_0023052	denotes	signal
T6186	2074-2080	http://purl.obolibrary.org/obo/GO_0023052	denotes	signal
T6187	2515-2521	http://purl.obolibrary.org/obo/GO_0023052	denotes	signal
T6188	506-527	http://purl.obolibrary.org/obo/GO_0005049	denotes	binding to importin-α
T6189	574-590	http://purl.obolibrary.org/obo/GO_0051092	denotes	NF-κB activation
T6190	2057-2073	http://purl.obolibrary.org/obo/GO_0051092	denotes	NF-κB activation
T6191	955-970	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T6192	2346-2361	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T6193	2540-2555	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T6194	1794-1797	http://purl.obolibrary.org/obo/GO_0008384	denotes	IKK
T6195	2057-2080	http://purl.obolibrary.org/obo/GO_1901224	denotes	NF-κB activation signal
T6196	2135-2152	http://purl.obolibrary.org/obo/GO_0051169	denotes	nuclear transport
T6197	2143-2152	http://purl.obolibrary.org/obo/GO_0006810	denotes	transport

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T6198	506-513	http://purl.obolibrary.org/obo/GO_0005488	denotes	binding
T6199	506-527	http://purl.obolibrary.org/obo/GO_0005049	denotes	binding to importin-α
T6200	1794-1797	http://purl.obolibrary.org/obo/GO_0008384	denotes	IKK

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T6201	453-458	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6202	868-873	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6203	991-996	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6204	1137-1142	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6205	1551-1556	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T6206	1713-1718	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells

sentences

Id	Subject	Object	Predicate	Lexical cue
T5142	0-47	Sentence	denotes	IκBα degradation and RPS3 nuclear translocation
T5143	48-116	Sentence	denotes	Importin-α regulates the nuclear import of NF-κB Rel subunits23, 24.
T5144	117-269	Sentence	denotes	RPS3 harbors a nuclear localization signal (NLS) sequence and its nuclear translocation occurs in parallel to, but independently of, p65 translocation6.
T5145	270-338	Sentence	denotes	We envisioned that RPS3 could also utilize the importin-α/β pathway.
T5146	339-469	Sentence	denotes	Consistent with this notion, RPS3 association with importin-α, but not importin-β, was enhanced in TNF–stimulated cells (Fig. 3a).
T5147	470-591	Sentence	denotes	Therefore, we examined whether RPS3 binding to importin-α is essential for nuclear translocation during NF-κB activation.
T5148	592-807	Sentence	denotes	Since IκBα degradation is a prerequisite to unmask the NLS of p65, and both RPS3 and IκBα bind to p65 in the cytoplasmic inhibitory complex, we tested whether IκBα degradation is required for the liberation of RPS3.
T5149	808-987	Sentence	denotes	We measured the association of RPS3 with importin-α in 293T cells overexpressing wild-type IκBα or an IκBα mutant (SSAA) resistant to IKKβ-induced phosphorylation and degradation.
T5150	988-1143	Sentence	denotes	In cells transfected with wild-type IκBα, TNF stimulation augmented the interaction of RPS3 and importin-α to a similar degree as in non-transfected cells.
T5151	1144-1269	Sentence	denotes	By contrast, we observed that the RPS3-importin-α association was abolished by the presence of non-degradable IκBα (Fig. 3b).
T5152	1270-1458	Sentence	denotes	To examine whether IκBα is the only cytoplasmic barrier precluding RPS3 nuclear translocation, we measured both RPS3-importin-α association and nuclear RPS3 after reducing IκBα expression.
T5153	1459-1574	Sentence	denotes	Compared with nonspecific siRNA, siRNA targeting of IκBα completely depleted IκBα in Jurkat cells (Fig. 3c, input).
T5154	1575-1702	Sentence	denotes	Nevertheless, the RPS3-importin-α association was not augmented (Fig. 3c), nor was significant nuclear RPS3 detected (Fig. 3d).
T5155	1703-2015	Sentence	denotes	Moreover, cells treated with sodium pervanadate (Pv) to induce IκBα degradation through an IKK-independent mechanism25-27 did not show increased association between RPS3 and importin-α (Fig. 3e and Supplementary Fig. 3b) or nuclear accumulation of RPS3, despite complete IκBα degradation (Supplementary Fig. 3c).
T5156	2016-2184	Sentence	denotes	We further examined whether a subsequent NF-κB activation signal independently promotes the importin-α association and nuclear transport of RPS3 after IκBα degradation.
T5157	2185-2334	Sentence	denotes	We found that TNF stimulation following Pv treatment was required for the RPS3-importin-α association, comparable to TNF stimulation alone (Fig. 3e).
T5158	2335-2492	Sentence	denotes	Thus, IκBα phosphorylation and degradation itself is required but not sufficient to cause RPS3 association with importin-α followed by nuclear translocation.
T5159	2493-2577	Sentence	denotes	Rather, an additional signal, potentially IKKβ phosphorylation of RPS3, is required.
T50	0-47	Sentence	denotes	IκBα degradation and RPS3 nuclear translocation
T51	48-116	Sentence	denotes	Importin-α regulates the nuclear import of NF-κB Rel subunits23, 24.
T52	117-269	Sentence	denotes	RPS3 harbors a nuclear localization signal (NLS) sequence and its nuclear translocation occurs in parallel to, but independently of, p65 translocation6.
T53	270-338	Sentence	denotes	We envisioned that RPS3 could also utilize the importin-α/β pathway.
T54	339-469	Sentence	denotes	Consistent with this notion, RPS3 association with importin-α, but not importin-β, was enhanced in TNF–stimulated cells (Fig. 3a).
T55	470-591	Sentence	denotes	Therefore, we examined whether RPS3 binding to importin-α is essential for nuclear translocation during NF-κB activation.
T56	592-807	Sentence	denotes	Since IκBα degradation is a prerequisite to unmask the NLS of p65, and both RPS3 and IκBα bind to p65 in the cytoplasmic inhibitory complex, we tested whether IκBα degradation is required for the liberation of RPS3.
T57	808-987	Sentence	denotes	We measured the association of RPS3 with importin-α in 293T cells overexpressing wild-type IκBα or an IκBα mutant (SSAA) resistant to IKKβ-induced phosphorylation and degradation.
T58	988-1143	Sentence	denotes	In cells transfected with wild-type IκBα, TNF stimulation augmented the interaction of RPS3 and importin-α to a similar degree as in non-transfected cells.
T59	1144-1269	Sentence	denotes	By contrast, we observed that the RPS3-importin-α association was abolished by the presence of non-degradable IκBα (Fig. 3b).
T60	1270-1458	Sentence	denotes	To examine whether IκBα is the only cytoplasmic barrier precluding RPS3 nuclear translocation, we measured both RPS3-importin-α association and nuclear RPS3 after reducing IκBα expression.
T61	1459-1574	Sentence	denotes	Compared with nonspecific siRNA, siRNA targeting of IκBα completely depleted IκBα in Jurkat cells (Fig. 3c, input).
T62	1575-1702	Sentence	denotes	Nevertheless, the RPS3-importin-α association was not augmented (Fig. 3c), nor was significant nuclear RPS3 detected (Fig. 3d).
T63	1703-2015	Sentence	denotes	Moreover, cells treated with sodium pervanadate (Pv) to induce IκBα degradation through an IKK-independent mechanism25-27 did not show increased association between RPS3 and importin-α (Fig. 3e and Supplementary Fig. 3b) or nuclear accumulation of RPS3, despite complete IκBα degradation (Supplementary Fig. 3c).
T64	2016-2184	Sentence	denotes	We further examined whether a subsequent NF-κB activation signal independently promotes the importin-α association and nuclear transport of RPS3 after IκBα degradation.
T65	2185-2334	Sentence	denotes	We found that TNF stimulation following Pv treatment was required for the RPS3-importin-α association, comparable to TNF stimulation alone (Fig. 3e).
T66	2335-2492	Sentence	denotes	Thus, IκBα phosphorylation and degradation itself is required but not sufficient to cause RPS3 association with importin-α followed by nuclear translocation.
T67	2493-2577	Sentence	denotes	Rather, an additional signal, potentially IKKβ phosphorylation of RPS3, is required.

events-check-again

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T6649	0-4	Protein	denotes	IκBα
T6650	5-16	Protein_catabolism	denotes	degradation		true
T6651	21-25	Protein	denotes	RPS3
T6652	26-33	Entity	denotes	nuclear
T6653	34-47	Localization	denotes	translocation		true
T6654	59-68	Regulation	denotes	regulates
T6655	73-80	Entity	denotes	nuclear
T6656	81-87	Localization	denotes	import
T6657	97-100	Protein	denotes	Rel
T6658	117-121	Protein	denotes	RPS3
T6659	183-190	Entity	denotes	nuclear
T6660	191-204	Localization	denotes	translocation
T6661	250-253	Protein	denotes	p65
T6662	254-267	Localization	denotes	translocation
T6663	289-293	Protein	denotes	RPS3
T6664	368-372	Protein	denotes	RPS3
T6665	501-505	Protein	denotes	RPS3
T6666	506-513	Binding	denotes	binding
T6667	531-540	Positive_regulation	denotes	essential
T6668	545-552	Entity	denotes	nuclear
T6669	553-566	Localization	denotes	translocation
T6670	598-602	Protein	denotes	IκBα
T6671	603-614	Protein_catabolism	denotes	degradation
T6672	620-632	Positive_regulation	denotes	prerequisite
T6673	636-642	Regulation	denotes	unmask
T6674	647-650	Entity	denotes	NLS
T6675	654-657	Protein	denotes	p65
T6676	668-672	Protein	denotes	RPS3
T6677	677-681	Protein	denotes	IκBα
T6678	682-686	Binding	denotes	bind
T6679	682-686	Binding	denotes	bind
T6680	690-693	Protein	denotes	p65
T6681	751-755	Protein	denotes	IκBα
T6682	756-767	Protein_catabolism	denotes	degradation
T6683	771-779	Positive_regulation	denotes	required		true
T6684	788-798	Localization	denotes	liberation
T6685	802-806	Protein	denotes	RPS3
T6686	824-835	Binding	denotes	association		true
T6687	839-843	Protein	denotes	RPS3
T6688	899-903	Protein	denotes	IκBα
T6689	910-914	Protein	denotes	IκBα
T6690	923-927	Negative_regulation	denotes	SSAA
T6691	929-938	Negative_regulation	denotes	resistant
T6692	929-938	Negative_regulation	denotes	resistant
T6693	942-946	Protein	denotes	IKKβ
T6694	947-954	Positive_regulation	denotes	induced
T6695	947-954	Positive_regulation	denotes	induced
T6696	955-970	Phosphorylation	denotes	phosphorylation
T6697	975-986	Protein_catabolism	denotes	degradation
T6698	1024-1028	Protein	denotes	IκBα
T6699	1046-1055	Positive_regulation	denotes	augmented
T6700	1060-1071	Binding	denotes	interaction
T6701	1075-1079	Protein	denotes	RPS3
T6702	1178-1182	Protein	denotes	RPS3
T6703	1194-1205	Binding	denotes	association
T6704	1210-1219	Negative_regulation	denotes	abolished
T6705	1243-1253	Protein_catabolism	denotes	degradable	true
T6706	1254-1258	Protein	denotes	IκBα
T6707	1289-1293	Protein	denotes	IκBα
T6708	1326-1336	Negative_regulation	denotes	precluding		true
T6709	1337-1341	Protein	denotes	RPS3
T6710	1342-1349	Entity	denotes	nuclear
T6711	1350-1363	Localization	denotes	translocation
T6712	1382-1386	Protein	denotes	RPS3
T6713	1398-1409	Binding	denotes	association		true
T6714	1422-1426	Protein	denotes	RPS3
T6715	1433-1441	Negative_regulation	denotes	reducing
T6716	1442-1446	Protein	denotes	IκBα
T6717	1447-1457	Gene_expression	denotes	expression
T6718	1492-1497	Protein	denotes	siRNA
T6719	1511-1515	Protein	denotes	IκBα
T6720	1527-1535	Negative_regulation	denotes	depleted
T6721	1536-1540	Protein	denotes	IκBα
T6722	1593-1597	Protein	denotes	RPS3
T6723	1609-1620	Binding	denotes	association
T6724	1629-1638	Positive_regulation	denotes	augmented	true
T6725	1670-1677	Entity	denotes	nuclear
T6726	1678-1682	Protein	denotes	RPS3
T6727	1683-1691	Localization	denotes	detected	true
T6728	1759-1765	Positive_regulation	denotes	induce
T6729	1766-1770	Protein	denotes	IκBα
T6730	1771-1782	Protein_catabolism	denotes	degradation
T6731	1838-1847	Positive_regulation	denotes	increased	true
T6732	1838-1847	Positive_regulation	denotes	increased	true
T6733	1848-1859	Binding	denotes	association
T6734	1868-1872	Protein	denotes	RPS3
T6735	1927-1934	Entity	denotes	nuclear
T6736	1935-1947	Localization	denotes	accumulation
T6737	1951-1955	Protein	denotes	RPS3
T6738	1974-1978	Protein	denotes	IκBα
T6739	1979-1990	Protein_catabolism	denotes	degradation
T6740	2095-2103	Positive_regulation	denotes	promotes		true
T6741	2095-2103	Positive_regulation	denotes	promotes		true
T6742	2119-2130	Binding	denotes	association
T6743	2135-2142	Entity	denotes	nuclear
T6744	2143-2152	Localization	denotes	transport
T6745	2156-2160	Protein	denotes	RPS3
T6746	2167-2171	Protein	denotes	IκBα
T6747	2172-2183	Protein_catabolism	denotes	degradation
T6748	2242-2250	Positive_regulation	denotes	required
T6749	2259-2263	Protein	denotes	RPS3
T6750	2275-2286	Binding	denotes	association
T6751	2341-2345	Protein	denotes	IκBα
T6752	2346-2361	Phosphorylation	denotes	phosphorylation
T6753	2366-2377	Protein_catabolism	denotes	degradation
T6754	2419-2424	Positive_regulation	denotes	cause
T6755	2419-2424	Positive_regulation	denotes	cause
T6756	2425-2429	Protein	denotes	RPS3
T6757	2430-2441	Binding	denotes	association
T6758	2458-2466	Positive_regulation	denotes	followed
T6759	2470-2477	Entity	denotes	nuclear
T6760	2478-2491	Localization	denotes	translocation
T6761	2535-2539	Protein	denotes	IKKβ
T6762	2540-2555	Phosphorylation	denotes	phosphorylation
T6763	2559-2563	Protein	denotes	RPS3
R5232	T6649	T6650	themeOf	IκBα,degradation
R5239	T6651	T6653	themeOf	RPS3,translocation
R5243	T6652	T6653	locationOf	nuclear,translocation
R5246	T6655	T6656	locationOf	nuclear,import
R5250	T6656	T6654	themeOf	import,regulates
R5255	T6657	T6656	themeOf	Rel,import
R5260	T6658	T6660	themeOf	RPS3,translocation
R5265	T6659	T6660	locationOf	nuclear,translocation
R5269	T6661	T6662	themeOf	p65,translocation
R5270	T6665	T6666	themeOf	RPS3,binding
R5272	T6665	T6669	themeOf	RPS3,translocation
R5274	T6666	T6667	causeOf	binding,essential
R5277	T6668	T6669	locationOf	nuclear,translocation
R5279	T6669	T6667	themeOf	translocation,essential
R5282	T6670	T6671	themeOf	IκBα,degradation
R5285	T6671	T6672	causeOf	degradation,prerequisite
R5288	T6673	T6672	themeOf	unmask,prerequisite
R5292	T6674	T6673	themeOf	NLS,unmask
R5295	T6674	T6675	partOf	NLS,p65
R5297	T6676	T6678	themeOf	RPS3,bind
R5302	T6677	T6679	themeOf	IκBα,bind
R5304	T6680	T6678	themeOf	p65,bind
R5311	T6680	T6679	themeOf	p65,bind
R5312	T6681	T6682	themeOf	IκBα,degradation
R5319	T6682	T6683	causeOf	degradation,required
R5320	T6684	T6683	themeOf	liberation,required
R5325	T6685	T6684	themeOf	RPS3,liberation
R5328	T6687	T6686	themeOf	RPS3,association
R5330	T6689	T6690	themeOf	IκBα,SSAA
R5331	T6689	T6696	themeOf	IκBα,phosphorylation
R5332	T6689	T6697	themeOf	IκBα,degradation
R5333	T6690	T6692	causeOf	SSAA,resistant
R5334	T6690	T6691	causeOf	SSAA,resistant
R5335	T6737	T6736	themeOf	RPS3,accumulation
R5336	T6693	T6695	causeOf	IKKβ,induced
R5337	T6738	T6739	themeOf	IκBα,degradation
R5338	T6693	T6694	causeOf	IKKβ,induced
R5339	T6742	T6741	themeOf	association,promotes
R5340	T6694	T6691	themeOf	induced,resistant
R5341	T6743	T6744	locationOf	nuclear,transport
R5342	T6744	T6740	themeOf	transport,promotes
R5343	T6695	T6692	themeOf	induced,resistant
R5344	T6745	T6742	themeOf	RPS3,association
R5345	T6745	T6744	themeOf	RPS3,transport
R5346	T6746	T6747	themeOf	IκBα,degradation
R5347	T6696	T6695	themeOf	phosphorylation,induced
R5348	T6749	T6750	themeOf	RPS3,association
R5349	T6697	T6694	themeOf	degradation,induced
R5350	T6750	T6748	themeOf	association,required
R5351	T6751	T6752	themeOf	IκBα,phosphorylation
R5352	T6751	T6753	themeOf	IκBα,degradation
R5353	T6752	T6755	causeOf	phosphorylation,cause
R5354	T6753	T6754	causeOf	degradation,cause
R5355	T6700	T6699	themeOf	interaction,augmented
R5356	T6756	T6757	themeOf	RPS3,association
R5357	T6756	T6760	themeOf	RPS3,translocation
R5358	T6757	T6758	causeOf	association,followed
R5359	T6758	T6755	themeOf	followed,cause
R5360	T6758	T6754	themeOf	followed,cause
R5361	T6701	T6700	themeOf	RPS3,interaction
R5362	T6759	T6760	locationOf	nuclear,translocation
R5363	T6760	T6758	themeOf	translocation,followed
R5364	T6702	T6703	themeOf	RPS3,association
R5365	T6763	T6762	themeOf	RPS3,phosphorylation
R5366	T6703	T6704	themeOf	association,abolished
R5367	T6705	T6704	causeOf	degradable,abolished
R5368	T6706	T6705	themeOf	IκBα,degradable
R5369	T6707	T6708	causeOf	IκBα,precluding
R5370	T6709	T6711	themeOf	RPS3,translocation
R5372	T6710	T6711	locationOf	nuclear,translocation
R5375	T6711	T6708	themeOf	translocation,precluding
R5376	T6712	T6713	themeOf	RPS3,association
R5380	T6716	T6717	themeOf	IκBα,expression
R5383	T6717	T6715	themeOf	expression,reducing
R5385	T6718	T6720	causeOf	siRNA,depleted
R5388	T6720	T6724	causeOf	depleted,augmented
R5392	T6721	T6720	themeOf	IκBα,depleted
R5395	T6722	T6723	themeOf	RPS3,association
R5399	T6723	T6724	themeOf	association,augmented
R5402	T6725	T6727	locationOf	nuclear,detected
R5406	T6726	T6727	themeOf	RPS3,detected
R5409	T6728	T6731	causeOf	induce,increased
R5412	T6728	T6732	causeOf	induce,increased
R5416	T6729	T6730	themeOf	IκBα,degradation
R5417	T6730	T6728	themeOf	degradation,induce
R5420	T6733	T6731	themeOf	association,increased
R5423	T6734	T6733	themeOf	RPS3,association
R5425	T6735	T6736	locationOf	nuclear,accumulation
R5427	T6736	T6732	themeOf	accumulation,increased

bionlp-st-ge-2016-reference-tees

Id	Subject	Object	Predicate	Lexical cue
T6207	0-4	Protein	denotes	IκBα
T6208	21-25	Protein	denotes	RPS3
T6209	5-16	Protein_catabolism	denotes	degradation
T6210	26-33	Entity	denotes	nuclear
T6211	34-47	Localization	denotes	translocation
T6212	48-58	Protein	denotes	Importin-α
T6213	91-111	Protein	denotes	NF-κB Rel subunits23
T6214	73-80	Entity	denotes	nuclear
T6215	81-87	Localization	denotes	import
T6216	59-68	Regulation	denotes	regulates
T6217	117-121	Protein	denotes	RPS3
T6218	250-253	Protein	denotes	p65
T6219	254-268	Protein	denotes	translocation6
T6220	183-190	Entity	denotes	nuclear
T6221	191-204	Localization	denotes	translocation
T6222	191-204	Localization	denotes	translocation
T6223	191-204	Localization	denotes	translocation
T6224	289-293	Protein	denotes	RPS3
T6225	317-329	Protein	denotes	importin-α/β
T6226	368-372	Protein	denotes	RPS3
T6227	390-400	Protein	denotes	importin-α
T6228	438-441	Protein	denotes	TNF
T6229	460-467	Protein	denotes	Fig. 3a
T6230	373-384	Binding	denotes	association
T6231	426-434	Positive_regulation	denotes	enhanced
T6232	501-505	Protein	denotes	RPS3
T6233	517-527	Protein	denotes	importin-α
T6234	574-579	Protein	denotes	NF-κB
T6235	506-513	Binding	denotes	binding
T6236	545-552	Entity	denotes	nuclear
T6237	598-602	Protein	denotes	IκBα
T6238	654-657	Protein	denotes	p65
T6239	668-672	Protein	denotes	RPS3
T6240	677-681	Protein	denotes	IκBα
T6241	690-693	Protein	denotes	p65
T6242	751-770	Protein	denotes	IκBα degradation is
T6243	802-806	Protein	denotes	RPS3
T6244	603-614	Protein_catabolism	denotes	degradation
T6245	682-686	Binding	denotes	bind
T6246	682-686	Binding	denotes	bind
T6247	682-686	Binding	denotes	bind
T6248	788-798	Protein_catabolism	denotes	liberation
T6249	771-779	Positive_regulation	denotes	required
T6250	839-843	Protein	denotes	RPS3
T6251	889-903	Protein	denotes	wild-type IκBα
T6252	910-921	Protein	denotes	IκBα mutant
T6253	923-927	Protein	denotes	SSAA
T6254	942-946	Protein	denotes	IKKβ
T6255	824-835	Binding	denotes	association
T6256	874-888	Positive_regulation	denotes	overexpressing
T6257	874-888	Positive_regulation	denotes	overexpressing
T6258	874-888	Positive_regulation	denotes	overexpressing
T6259	955-970	Phosphorylation	denotes	phosphorylation
T6260	955-970	Phosphorylation	denotes	phosphorylation
T6261	975-986	Protein_catabolism	denotes	degradation
T6262	975-986	Protein_catabolism	denotes	degradation
T6263	929-938	Positive_regulation	denotes	resistant
T6264	929-938	Positive_regulation	denotes	resistant
T6265	947-954	Positive_regulation	denotes	induced
T6266	947-954	Positive_regulation	denotes	induced
T6267	1024-1028	Protein	denotes	IκBα
T6268	1030-1033	Protein	denotes	TNF
T6269	1075-1079	Protein	denotes	RPS3
T6270	1084-1094	Protein	denotes	importin-α
T6271	997-1008	Gene_expression	denotes	transfected
T6272	997-1008	Positive_regulation	denotes	transfected
T6273	1060-1071	Binding	denotes	interaction
T6274	1046-1055	Positive_regulation	denotes	augmented
T6275	1178-1182	Protein	denotes	RPS3
T6276	1254-1258	Protein	denotes	IκBα
T6277	1260-1267	Protein	denotes	Fig. 3b
T6278	1239-1253	Protein_catabolism	denotes	non-degradable
T6279	1239-1253	Protein_catabolism	denotes	non-degradable
T6280	1289-1293	Protein	denotes	IκBα
T6281	1337-1341	Protein	denotes	RPS3
T6282	1382-1386	Protein	denotes	RPS3
T6283	1387-1395	Protein	denotes	importin
T6284	1422-1426	Protein	denotes	RPS3
T6285	1442-1446	Protein	denotes	IκBα
T6286	1342-1349	Entity	denotes	nuclear
T6287	1350-1363	Localization	denotes	translocation
T6288	1447-1457	Gene_expression	denotes	expression
T6289	1326-1336	Positive_regulation	denotes	precluding
T6290	1433-1441	Negative_regulation	denotes	reducing
T6291	1511-1515	Protein	denotes	IκBα
T6292	1536-1540	Protein	denotes	IκBα
T6293	1527-1535	Negative_regulation	denotes	depleted
T6294	1593-1597	Protein	denotes	RPS3
T6295	1678-1682	Protein	denotes	RPS3
T6296	1629-1638	Positive_regulation	denotes	augmented
T6297	1766-1770	Protein	denotes	IκBα
T6298	1868-1872	Protein	denotes	RPS3
T6299	1877-1887	Protein	denotes	importin-α
T6300	1889-1892	Protein	denotes	Fig
T6301	1894-1896	Protein	denotes	3e
T6302	1901-1922	Protein	denotes	Supplementary Fig. 3b
T6303	1951-1955	Protein	denotes	RPS3
T6304	2011-2013	Protein	denotes	3c
T6305	1771-1782	Protein_catabolism	denotes	degradation
T6306	1927-1934	Entity	denotes	nuclear
T6307	1935-1947	Positive_regulation	denotes	accumulation
T6308	1759-1765	Positive_regulation	denotes	induce
T6309	1838-1847	Positive_regulation	denotes	increased
T6310	2060-2062	Protein	denotes	κB
T6311	2108-2118	Protein	denotes	importin-α
T6312	2156-2160	Protein	denotes	RPS3
T6313	2167-2171	Protein	denotes	IκBα
T6314	2119-2130	Binding	denotes	association
T6315	2172-2183	Protein_catabolism	denotes	degradation
T6316	2172-2183	Protein_catabolism	denotes	degradation
T6317	2095-2103	Positive_regulation	denotes	promotes
T6318	2199-2202	Protein	denotes	TNF
T6319	2259-2263	Protein	denotes	RPS3
T6320	2302-2305	Protein	denotes	TNF
T6321	2341-2345	Protein	denotes	IκBα
T6322	2425-2429	Protein	denotes	RPS3
T6323	2447-2457	Protein	denotes	importin-α
T6324	2346-2361	Phosphorylation	denotes	phosphorylation
T6325	2366-2377	Protein_catabolism	denotes	degradation
T6326	2430-2441	Binding	denotes	association
T6327	2470-2477	Entity	denotes	nuclear
T6328	2478-2491	Localization	denotes	translocation
T6329	2419-2424	Positive_regulation	denotes	cause
T6330	2535-2539	Protein	denotes	IKKβ
T6331	2559-2563	Protein	denotes	RPS3
T6332	2540-2555	Phosphorylation	denotes	phosphorylation
T6333	2540-2555	Phosphorylation	denotes	phosphorylation
R5010	T6207	T6209	themeOf	IκBα,degradation
R5011	T6208	T6211	themeOf	RPS3,translocation
R5012	T6210	T6211	locationOf	nuclear,translocation
R5013	T6212	T6216	causeOf	Importin-α,regulates
R5014	T6213	T6215	themeOf	NF-κB Rel subunits23,import
R5015	T6214	T6215	locationOf	nuclear,import
R5016	T6215	T6216	themeOf	import,regulates
R5017	T6217	T6221	themeOf	RPS3,translocation
R5018	T6218	T6222	themeOf	p65,translocation
R5019	T6219	T6223	themeOf	translocation6,translocation
R5020	T6220	T6221	locationOf	nuclear,translocation
R5021	T6220	T6222	locationOf	nuclear,translocation
R5022	T6220	T6223	locationOf	nuclear,translocation
R5023	T6226	T6230	themeOf	RPS3,association
R5024	T6227	T6230	themeOf	importin-α,association
R5025	T6230	T6231	themeOf	association,enhanced
R5026	T6232	T6235	themeOf	RPS3,binding
R5027	T6233	T6235	themeOf	importin-α,binding
R5028	T6237	T6244	themeOf	IκBα,degradation
R5029	T6239	T6246	themeOf	RPS3,bind
R5030	T6240	T6247	themeOf	IκBα,bind
R5031	T6241	T6245	themeOf	p65,bind
R5032	T6241	T6246	themeOf	p65,bind
R5033	T6241	T6247	themeOf	p65,bind
R5034	T6242	T6249	causeOf	IκBα degradation is,required
R5035	T6243	T6248	themeOf	RPS3,liberation
R5036	T6248	T6249	themeOf	liberation,required
R5037	T6250	T6255	themeOf	RPS3,association
R5038	T6251	T6256	themeOf	wild-type IκBα,overexpressing
R5039	T6252	T6257	themeOf	IκBα mutant,overexpressing
R5040	T6252	T6259	themeOf	IκBα mutant,phosphorylation
R5041	T6252	T6261	themeOf	IκBα mutant,degradation
R5042	T6253	T6258	themeOf	SSAA,overexpressing
R5043	T6253	T6260	themeOf	SSAA,phosphorylation
R5044	T6253	T6262	themeOf	SSAA,degradation
R5045	T6254	T6265	causeOf	IKKβ,induced
R5046	T6254	T6266	causeOf	IKKβ,induced
R5047	T6259	T6265	themeOf	phosphorylation,induced
R5048	T6260	T6266	themeOf	phosphorylation,induced
R5049	T6261	T6263	themeOf	degradation,resistant
R5050	T6262	T6264	themeOf	degradation,resistant
R5051	T6267	T6271	themeOf	IκBα,transfected
R5052	T6269	T6273	themeOf	RPS3,interaction
R5053	T6271	T6272	themeOf	transfected,transfected
R5054	T6273	T6274	themeOf	interaction,augmented
R5055	T6295	T6296	themeOf	RPS3,augmented
R5056	T6276	T6278	themeOf	IκBα,non-degradable
R5057	T6297	T6305	themeOf	IκBα,degradation
R5058	T6277	T6279	themeOf	Fig. 3b,non-degradable
R5059	T6303	T6307	themeOf	RPS3,accumulation
R5060	T6281	T6287	themeOf	RPS3,translocation
R5061	T6305	T6308	themeOf	degradation,induce
R5062	T6306	T6307	Site	nuclear,accumulation
R5063	T6307	T6309	themeOf	accumulation,increased
R5064	T6285	T6288	themeOf	IκBα,expression
R5065	T6311	T6314	themeOf	importin-α,association
R5066	T6312	T6314	themeOf	RPS3,association
R5067	T6312	T6315	themeOf	RPS3,degradation
R5068	T6313	T6316	themeOf	IκBα,degradation
R5069	T6314	T6317	themeOf	association,promotes
R5070	T6286	T6287	locationOf	nuclear,translocation
R5071	T6287	T6289	themeOf	translocation,precluding
R5072	T6288	T6290	themeOf	expression,reducing
R5073	T6321	T6324	themeOf	IκBα,phosphorylation
R5074	T6321	T6325	themeOf	IκBα,degradation
R5075	T6322	T6326	themeOf	RPS3,association
R5076	T6323	T6326	themeOf	importin-α,association
R5077	T6323	T6328	themeOf	importin-α,translocation
R5078	T6292	T6293	themeOf	IκBα,depleted
R5079	T6326	T6329	themeOf	association,cause
R5080	T6327	T6328	locationOf	nuclear,translocation
R5082	T6330	T6332	themeOf	IKKβ,phosphorylation
R5083	T6331	T6333	themeOf	RPS3,phosphorylation

bionlp-st-ge-2016-reference

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T5027	0-4	Protein	denotes	IκBα
T5028	5-16	Protein_catabolism	denotes	degradation		true
T5029	21-25	Protein	denotes	RPS3
T5030	26-33	Entity	denotes	nuclear
T5031	34-47	Localization	denotes	translocation		true
T5032	59-68	Regulation	denotes	regulates
T5033	73-80	Entity	denotes	nuclear
T5034	81-87	Localization	denotes	import
T5035	97-100	Protein	denotes	Rel
T5036	117-121	Protein	denotes	RPS3
T5037	183-190	Entity	denotes	nuclear
T5038	191-204	Localization	denotes	translocation
T5039	250-253	Protein	denotes	p65
T5040	254-267	Localization	denotes	translocation
T5041	289-293	Protein	denotes	RPS3
T5042	368-372	Protein	denotes	RPS3
T5043	501-505	Protein	denotes	RPS3
T5044	506-513	Binding	denotes	binding
T5045	531-540	Positive_regulation	denotes	essential
T5046	545-552	Entity	denotes	nuclear
T5047	553-566	Localization	denotes	translocation
T5048	598-602	Protein	denotes	IκBα
T5049	603-614	Protein_catabolism	denotes	degradation
T5050	620-632	Positive_regulation	denotes	prerequisite
T5051	636-642	Regulation	denotes	unmask
T5052	647-650	Entity	denotes	NLS
T5053	654-657	Protein	denotes	p65
T5054	668-672	Protein	denotes	RPS3
T5055	677-681	Protein	denotes	IκBα
T5056	682-686	Binding	denotes	bind
T5057	682-686	Binding	denotes	bind
T5058	690-693	Protein	denotes	p65
T5059	751-755	Protein	denotes	IκBα
T5060	756-767	Protein_catabolism	denotes	degradation
T5061	771-779	Positive_regulation	denotes	required		true
T5062	788-798	Localization	denotes	liberation
T5063	802-806	Protein	denotes	RPS3
T5064	824-835	Binding	denotes	association		true
T5065	839-843	Protein	denotes	RPS3
T5066	899-903	Protein	denotes	IκBα
T5067	910-914	Protein	denotes	IκBα
T5068	923-927	Negative_regulation	denotes	SSAA
T5069	929-938	Negative_regulation	denotes	resistant
T5070	929-938	Negative_regulation	denotes	resistant
T5071	942-946	Protein	denotes	IKKβ
T5072	947-954	Positive_regulation	denotes	induced
T5073	947-954	Positive_regulation	denotes	induced
T5074	955-970	Phosphorylation	denotes	phosphorylation
T5075	975-986	Protein_catabolism	denotes	degradation
T5076	1024-1028	Protein	denotes	IκBα
T5077	1046-1055	Positive_regulation	denotes	augmented
T5078	1060-1071	Binding	denotes	interaction
T5079	1075-1079	Protein	denotes	RPS3
T5080	1178-1182	Protein	denotes	RPS3
T5081	1194-1205	Binding	denotes	association
T5082	1210-1219	Negative_regulation	denotes	abolished
T5083	1243-1253	Protein_catabolism	denotes	degradable	true
T5084	1254-1258	Protein	denotes	IκBα
T5085	1289-1293	Protein	denotes	IκBα
T5086	1326-1336	Negative_regulation	denotes	precluding		true
T5087	1337-1341	Protein	denotes	RPS3
T5088	1342-1349	Entity	denotes	nuclear
T5089	1350-1363	Localization	denotes	translocation
T5090	1382-1386	Protein	denotes	RPS3
T5091	1398-1409	Binding	denotes	association		true
T5092	1422-1426	Protein	denotes	RPS3
T5093	1433-1441	Negative_regulation	denotes	reducing
T5094	1442-1446	Protein	denotes	IκBα
T5095	1447-1457	Gene_expression	denotes	expression
T5096	1492-1497	Protein	denotes	siRNA
T5097	1511-1515	Protein	denotes	IκBα
T5098	1527-1535	Negative_regulation	denotes	depleted
T5099	1536-1540	Protein	denotes	IκBα
T5100	1593-1597	Protein	denotes	RPS3
T5101	1609-1620	Binding	denotes	association
T5102	1629-1638	Positive_regulation	denotes	augmented	true
T5103	1670-1677	Entity	denotes	nuclear
T5104	1678-1682	Protein	denotes	RPS3
T5105	1683-1691	Localization	denotes	detected	true
T5106	1759-1765	Positive_regulation	denotes	induce
T5107	1766-1770	Protein	denotes	IκBα
T5108	1771-1782	Protein_catabolism	denotes	degradation
T5109	1838-1847	Positive_regulation	denotes	increased	true
T5110	1838-1847	Positive_regulation	denotes	increased	true
T5111	1848-1859	Binding	denotes	association
T5112	1868-1872	Protein	denotes	RPS3
T5113	1927-1934	Entity	denotes	nuclear
T5114	1935-1947	Localization	denotes	accumulation
T5115	1951-1955	Protein	denotes	RPS3
T5116	1974-1978	Protein	denotes	IκBα
T5117	1979-1990	Protein_catabolism	denotes	degradation
T5118	2095-2103	Positive_regulation	denotes	promotes		true
T5119	2095-2103	Positive_regulation	denotes	promotes		true
T5120	2119-2130	Binding	denotes	association
T5121	2135-2142	Entity	denotes	nuclear
T5122	2143-2152	Localization	denotes	transport
T5123	2156-2160	Protein	denotes	RPS3
T5124	2167-2171	Protein	denotes	IκBα
T5125	2172-2183	Protein_catabolism	denotes	degradation
T5126	2242-2250	Positive_regulation	denotes	required
T5127	2259-2263	Protein	denotes	RPS3
T5128	2275-2286	Binding	denotes	association
T5129	2341-2345	Protein	denotes	IκBα
T5130	2346-2361	Phosphorylation	denotes	phosphorylation
T5131	2366-2377	Protein_catabolism	denotes	degradation
T5132	2419-2424	Positive_regulation	denotes	cause
T5133	2419-2424	Positive_regulation	denotes	cause
T5134	2425-2429	Protein	denotes	RPS3
T5135	2430-2441	Binding	denotes	association
T5136	2458-2466	Positive_regulation	denotes	followed
T5137	2470-2477	Entity	denotes	nuclear
T5138	2478-2491	Localization	denotes	translocation
T5139	2535-2539	Protein	denotes	IKKβ
T5140	2540-2555	Phosphorylation	denotes	phosphorylation
T5141	2559-2563	Protein	denotes	RPS3
R4003	T5027	T5028	themeOf	IκBα,degradation
R4004	T5029	T5031	themeOf	RPS3,translocation
R4005	T5030	T5031	locationOf	nuclear,translocation
R4006	T5033	T5034	locationOf	nuclear,import
R4007	T5034	T5032	themeOf	import,regulates
R4008	T5035	T5034	themeOf	Rel,import
R4009	T5036	T5038	themeOf	RPS3,translocation
R4010	T5037	T5038	locationOf	nuclear,translocation
R4011	T5039	T5040	themeOf	p65,translocation
R4012	T5043	T5044	themeOf	RPS3,binding
R4013	T5043	T5047	themeOf	RPS3,translocation
R4014	T5044	T5045	causeOf	binding,essential
R4015	T5046	T5047	locationOf	nuclear,translocation
R4016	T5047	T5045	themeOf	translocation,essential
R4017	T5048	T5049	themeOf	IκBα,degradation
R4018	T5049	T5050	causeOf	degradation,prerequisite
R4019	T5051	T5050	themeOf	unmask,prerequisite
R4020	T5052	T5051	themeOf	NLS,unmask
R4021	T5052	T5053	partOf	NLS,p65
R4022	T5054	T5056	themeOf	RPS3,bind
R4023	T5055	T5057	themeOf	IκBα,bind
R4024	T5058	T5056	themeOf	p65,bind
R4025	T5058	T5057	themeOf	p65,bind
R4026	T5059	T5060	themeOf	IκBα,degradation
R4027	T5060	T5061	causeOf	degradation,required
R4028	T5062	T5061	themeOf	liberation,required
R4029	T5063	T5062	themeOf	RPS3,liberation
R4030	T5065	T5064	themeOf	RPS3,association
R4031	T5067	T5068	themeOf	IκBα,SSAA
R4032	T5067	T5074	themeOf	IκBα,phosphorylation
R4033	T5067	T5075	themeOf	IκBα,degradation
R4034	T5068	T5070	causeOf	SSAA,resistant
R4035	T5068	T5069	causeOf	SSAA,resistant
R4036	T5071	T5073	causeOf	IKKβ,induced
R4037	T5071	T5072	causeOf	IKKβ,induced
R4038	T5072	T5069	themeOf	induced,resistant
R4039	T5073	T5070	themeOf	induced,resistant
R4040	T5074	T5073	themeOf	phosphorylation,induced
R4041	T5075	T5072	themeOf	degradation,induced
R4042	T5078	T5077	themeOf	interaction,augmented
R4043	T5079	T5078	themeOf	RPS3,interaction
R4044	T5080	T5081	themeOf	RPS3,association
R4045	T5081	T5082	themeOf	association,abolished
R4046	T5083	T5082	causeOf	degradable,abolished
R4047	T5084	T5083	themeOf	IκBα,degradable
R4048	T5085	T5086	causeOf	IκBα,precluding
R4049	T5087	T5089	themeOf	RPS3,translocation
R4050	T5088	T5089	locationOf	nuclear,translocation
R4051	T5089	T5086	themeOf	translocation,precluding
R4052	T5090	T5091	themeOf	RPS3,association
R4053	T5094	T5095	themeOf	IκBα,expression
R4054	T5095	T5093	themeOf	expression,reducing
R4055	T5096	T5098	causeOf	siRNA,depleted
R4056	T5098	T5102	causeOf	depleted,augmented
R4057	T5099	T5098	themeOf	IκBα,depleted
R4058	T5100	T5101	themeOf	RPS3,association
R4059	T5101	T5102	themeOf	association,augmented
R4060	T5103	T5105	locationOf	nuclear,detected
R4061	T5104	T5105	themeOf	RPS3,detected
R4062	T5106	T5109	causeOf	induce,increased
R4063	T5106	T5110	causeOf	induce,increased
R4064	T5107	T5108	themeOf	IκBα,degradation
R4065	T5108	T5106	themeOf	degradation,induce
R4066	T5111	T5109	themeOf	association,increased
R4067	T5112	T5111	themeOf	RPS3,association
R4068	T5113	T5114	locationOf	nuclear,accumulation
R4069	T5114	T5110	themeOf	accumulation,increased
R4070	T5115	T5114	themeOf	RPS3,accumulation
R4071	T5116	T5117	themeOf	IκBα,degradation
R4072	T5120	T5119	themeOf	association,promotes
R4073	T5121	T5122	locationOf	nuclear,transport
R4074	T5122	T5118	themeOf	transport,promotes
R4075	T5123	T5120	themeOf	RPS3,association
R4076	T5123	T5122	themeOf	RPS3,transport
R4077	T5124	T5125	themeOf	IκBα,degradation
R4078	T5127	T5128	themeOf	RPS3,association
R4079	T5128	T5126	themeOf	association,required
R4080	T5129	T5130	themeOf	IκBα,phosphorylation
R4081	T5129	T5131	themeOf	IκBα,degradation
R4082	T5130	T5133	causeOf	phosphorylation,cause
R4083	T5131	T5132	causeOf	degradation,cause
R4084	T5134	T5135	themeOf	RPS3,association
R4085	T5134	T5138	themeOf	RPS3,translocation
R4086	T5135	T5136	causeOf	association,followed
R4087	T5136	T5133	themeOf	followed,cause
R4088	T5136	T5132	themeOf	followed,cause
R4089	T5137	T5138	locationOf	nuclear,translocation
R4090	T5138	T5136	themeOf	translocation,followed
R4091	T5141	T5140	themeOf	RPS3,phosphorylation

test2

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T4913	0-4	Protein	denotes	IκBα		true
T4914	5-16	Protein_catabolism	denotes	degradation		true
T4915	21-25	Protein	denotes	RPS3
T4916	26-33	Entity	denotes	nuclear
T4917	34-47	Localization	denotes	translocation
T4918	59-68	Regulation	denotes	regulates
T4919	73-80	Entity	denotes	nuclear
T4920	81-87	Localization	denotes	import
T4921	97-100	Protein	denotes	Rel
T4922	117-121	Protein	denotes	RPS3
T4923	132-139	Entity	denotes	nuclear
T4924	140-152	Localization	denotes	localization
T4925	183-190	Entity	denotes	nuclear
T4926	191-204	Localization	denotes	translocation
T4927	250-253	Protein	denotes	p65
T4928	254-268	Localization	denotes	translocation6		true
T4929	289-293	Protein	denotes	RPS3
T4930	368-372	Protein	denotes	RPS3		true
T4931	373-384	Binding	denotes	association
T4932	426-434	Positive_regulation	denotes	enhanced
T4933	501-505	Protein	denotes	RPS3
T4934	506-513	Binding	denotes	binding
T4935	531-540	Positive_regulation	denotes	essential
T4936	545-552	Entity	denotes	nuclear
T4937	553-566	Localization	denotes	translocation
T4938	598-602	Protein	denotes	IκBα
T4939	603-614	Protein_catabolism	denotes	degradation
T4940	620-632	Positive_regulation	denotes	prerequisite
T4941	636-642	Negative_regulation	denotes	unmask
T4942	647-650	Entity	denotes	NLS	true
T4943	654-657	Protein	denotes	p65		true
T4944	668-672	Protein	denotes	RPS3
T4945	677-681	Protein	denotes	IκBα		true
T4946	682-686	Binding	denotes	bind
T4947	690-693	Protein	denotes	p65
T4948	751-755	Protein	denotes	IκBα
T4949	756-767	Protein_catabolism	denotes	degradation
T4950	771-779	Positive_regulation	denotes	required	true
T4951	802-806	Protein	denotes	RPS3	true
T4952	824-835	Binding	denotes	association
T4953	839-843	Protein	denotes	RPS3
T4954	874-888	Gene_expression	denotes	overexpressing	true
T4955	899-903	Protein	denotes	IκBα
T4956	910-914	Protein	denotes	IκBα	true
T4957	923-927	Negative_regulation	denotes	SSAA
T4958	942-946	Protein	denotes	IKKβ
T4959	947-954	Positive_regulation	denotes	induced		true
T4960	955-970	Phosphorylation	denotes	phosphorylation
T4961	975-986	Protein_catabolism	denotes	degradation		true
T4962	997-1008	Gene_expression	denotes	transfected
T4963	1024-1028	Protein	denotes	IκBα
T4964	1046-1055	Positive_regulation	denotes	augmented
T4965	1060-1071	Binding	denotes	interaction
T4966	1075-1079	Protein	denotes	RPS3
T4967	1178-1182	Protein	denotes	RPS3
T4968	1194-1205	Binding	denotes	association
T4969	1210-1219	Negative_regulation	denotes	abolished
T4970	1243-1253	Protein_catabolism	denotes	degradable
T4971	1254-1258	Protein	denotes	IκBα
T4972	1289-1293	Protein	denotes	IκBα
T4973	1337-1341	Protein	denotes	RPS3
T4974	1342-1349	Entity	denotes	nuclear
T4975	1350-1363	Localization	denotes	translocation
T4976	1382-1386	Protein	denotes	RPS3
T4977	1398-1409	Binding	denotes	association
T4978	1414-1421	Entity	denotes	nuclear
T4979	1422-1426	Protein	denotes	RPS3
T4980	1433-1441	Negative_regulation	denotes	reducing
T4981	1442-1446	Protein	denotes	IκBα
T4982	1447-1457	Gene_expression	denotes	expression
T4983	1492-1497	Protein	denotes	siRNA
T4984	1511-1515	Protein	denotes	IκBα
T4985	1527-1535	Negative_regulation	denotes	depleted
T4986	1536-1540	Protein	denotes	IκBα
T4987	1593-1597	Protein	denotes	RPS3
T4988	1609-1620	Binding	denotes	association
T4989	1629-1638	Positive_regulation	denotes	augmented
T4990	1678-1682	Protein	denotes	RPS3
T4991	1683-1691	Localization	denotes	detected
T4992	1759-1765	Positive_regulation	denotes	induce
T4993	1766-1770	Protein	denotes	IκBα
T4994	1771-1782	Protein_catabolism	denotes	degradation
T4995	1838-1847	Positive_regulation	denotes	increased
T4996	1848-1859	Binding	denotes	association
T4997	1868-1872	Protein	denotes	RPS3
T4998	1927-1934	Entity	denotes	nuclear
T4999	1935-1947	Localization	denotes	accumulation
T5000	1951-1955	Protein	denotes	RPS3
T5001	1974-1978	Protein	denotes	IκBα
T5002	1979-1990	Protein_catabolism	denotes	degradation
T5003	2095-2103	Positive_regulation	denotes	promotes
T5004	2119-2130	Binding	denotes	association
T5005	2143-2152	Localization	denotes	transport
T5006	2156-2160	Protein	denotes	RPS3
T5007	2167-2171	Protein	denotes	IκBα
T5008	2172-2183	Protein_catabolism	denotes	degradation
T5009	2215-2224	Positive_regulation	denotes	following
T5010	2242-2250	Positive_regulation	denotes	required
T5011	2259-2263	Protein	denotes	RPS3
T5012	2275-2286	Binding	denotes	association
T5013	2341-2345	Protein	denotes	IκBα
T5014	2346-2361	Phosphorylation	denotes	phosphorylation
T5015	2366-2377	Protein_catabolism	denotes	degradation
T5016	2388-2396	Positive_regulation	denotes	required
T5017	2419-2424	Positive_regulation	denotes	cause
T5018	2425-2429	Protein	denotes	RPS3
T5019	2430-2441	Binding	denotes	association
T5020	2458-2466	Positive_regulation	denotes	followed
T5021	2470-2477	Entity	denotes	nuclear
T5022	2478-2491	Localization	denotes	translocation
T5023	2535-2539	Protein	denotes	IKKβ
T5024	2540-2555	Phosphorylation	denotes	phosphorylation
T5025	2559-2563	Protein	denotes	RPS3
T5026	2568-2576	Positive_regulation	denotes	required
R3921	T4913	T4914	themeOf	IκBα,degradation
R3922	T4915	T4917	themeOf	RPS3,translocation
R3923	T4916	T4917	locationOf	nuclear,translocation
R3924	T4919	T4920	locationOf	nuclear,import
R3925	T4920	T4918	themeOf	import,regulates
R3926	T4921	T4920	themeOf	Rel,import
R3927	T4922	T4926	themeOf	RPS3,translocation
R3928	T4923	T4926	locationOf	nuclear,translocation
R3929	T4923	T4924	locationOf	nuclear,localization
R3930	T4925	T4926	locationOf	nuclear,translocation
R3931	T4927	T4928	themeOf	p65,translocation6
R3932	T4930	T4931	themeOf	RPS3,association
R3933	T4931	T4932	themeOf	association,enhanced
R3934	T4933	T4937	themeOf	RPS3,translocation
R3935	T4933	T4934	themeOf	RPS3,binding
R3936	T4934	T4935	causeOf	binding,essential
R3937	T4936	T4937	locationOf	nuclear,translocation
R3938	T4937	T4935	themeOf	translocation,essential
R3939	T4938	T4939	themeOf	IκBα,degradation
R3940	T4939	T4940	causeOf	degradation,prerequisite
R3941	T4941	T4940	themeOf	unmask,prerequisite
R3942	T4942	T4943	partOf	NLS,p65
R3943	T4942	T4941	themeOf	NLS,unmask
R3944	T4942	T4944	partOf	NLS,RPS3
R3945	T4944	T4946	themeOf	RPS3,bind
R3946	T4945	T4946	themeOf	IκBα,bind
R3947	T4947	T4946	themeOf	p65,bind
R3948	T4948	T4949	themeOf	IκBα,degradation
R3949	T4949	T4950	causeOf	degradation,required
R3950	T4953	T4952	themeOf	RPS3,association
R3951	T4955	T4954	themeOf	IκBα,overexpressing
R3952	T4956	T4957	themeOf	IκBα,SSAA
R3953	T4956	T4961	themeOf	IκBα,degradation
R3954	T4956	T4960	themeOf	IκBα,phosphorylation
R3955	T4958	T4959	causeOf	IKKβ,induced
R3956	T4960	T4959	themeOf	phosphorylation,induced
R3957	T4961	T4959	themeOf	degradation,induced
R3958	T4963	T4962	themeOf	IκBα,transfected
R3959	T4965	T4964	themeOf	interaction,augmented
R3960	T4966	T4965	themeOf	RPS3,interaction
R3961	T4967	T4968	themeOf	RPS3,association
R3962	T4968	T4969	themeOf	association,abolished
R3963	T4970	T4969	causeOf	degradable,abolished
R3964	T4971	T4970	themeOf	IκBα,degradable
R3965	T4971	T4969	causeOf	IκBα,abolished
R3966	T4973	T4975	themeOf	RPS3,translocation
R3967	T4974	T4975	locationOf	nuclear,translocation
R3968	T4976	T4977	themeOf	RPS3,association
R3969	T4979	T4977	themeOf	RPS3,association
R3970	T4981	T4982	themeOf	IκBα,expression
R3971	T4982	T4980	themeOf	expression,reducing
R3972	T4983	T4985	causeOf	siRNA,depleted
R3973	T4986	T4985	themeOf	IκBα,depleted
R3974	T4987	T4988	themeOf	RPS3,association
R3975	T4988	T4989	themeOf	association,augmented
R3976	T4990	T4991	themeOf	RPS3,detected
R3977	T4993	T4994	themeOf	IκBα,degradation
R3978	T4994	T4992	themeOf	degradation,induce
R3979	T4996	T4995	themeOf	association,increased
R3980	T4997	T4996	themeOf	RPS3,association
R3981	T4998	T4999	locationOf	nuclear,accumulation
R3982	T5000	T4999	themeOf	RPS3,accumulation
R3983	T5001	T5002	themeOf	IκBα,degradation
R3984	T5004	T5003	themeOf	association,promotes
R3985	T5005	T5003	themeOf	transport,promotes
R3986	T5006	T5005	themeOf	RPS3,transport
R3987	T5007	T5008	themeOf	IκBα,degradation
R3988	T5011	T5012	themeOf	RPS3,association
R3989	T5012	T5010	themeOf	association,required
R3990	T5013	T5014	themeOf	IκBα,phosphorylation
R3991	T5013	T5015	themeOf	IκBα,degradation
R3992	T5014	T5017	causeOf	phosphorylation,cause
R3993	T5015	T5017	causeOf	degradation,cause
R3994	T5015	T5016	causeOf	degradation,required
R3995	T5018	T5019	themeOf	RPS3,association
R3996	T5018	T5022	themeOf	RPS3,translocation
R3997	T5019	T5017	themeOf	association,cause
R3998	T5019	T5020	causeOf	association,followed
R3999	T5021	T5022	locationOf	nuclear,translocation
R4000	T5022	T5020	themeOf	translocation,followed
R4001	T5024	T5026	themeOf	phosphorylation,required
R4002	T5025	T5024	themeOf	RPS3,phosphorylation

PMC:3062687 / 6708-9285 JSONTXT

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PMC:3062687 / 6708-9285 JSON TXT